id sid tid token lemma pos cord-276616-odmnvv7m 1 1 key key JJ cord-276616-odmnvv7m 1 2 : : : cord-276616-odmnvv7m 1 3 cord-276616-odmnvv7 cord-276616-odmnvv7 NNP cord-276616-odmnvv7m 1 4 m m CD cord-276616-odmnvv7m 1 5 authors author NNS cord-276616-odmnvv7m 1 6 : : : cord-276616-odmnvv7m 1 7 Darcel Darcel NNP cord-276616-odmnvv7m 1 8 , , , cord-276616-odmnvv7m 1 9 C. C. NNP cord-276616-odmnvv7m 1 10 title title NN cord-276616-odmnvv7m 1 11 : : : cord-276616-odmnvv7m 1 12 Reflections reflection NNS cord-276616-odmnvv7m 1 13 on on IN cord-276616-odmnvv7m 1 14 scrapie scrapie NN cord-276616-odmnvv7m 1 15 and and CC cord-276616-odmnvv7m 1 16 related related JJ cord-276616-odmnvv7m 1 17 disorders disorder NNS cord-276616-odmnvv7m 1 18 , , , cord-276616-odmnvv7m 1 19 with with IN cord-276616-odmnvv7m 1 20 consideration consideration NN cord-276616-odmnvv7m 1 21 of of IN cord-276616-odmnvv7m 1 22 the the DT cord-276616-odmnvv7m 1 23 possibility possibility NN cord-276616-odmnvv7m 1 24 of of IN cord-276616-odmnvv7m 1 25 a a DT cord-276616-odmnvv7m 1 26 viral viral JJ cord-276616-odmnvv7m 1 27 aetiology aetiology NN cord-276616-odmnvv7m 1 28 date date NN cord-276616-odmnvv7m 1 29 : : : cord-276616-odmnvv7m 1 30 1995 1995 CD cord-276616-odmnvv7m 1 31 journal journal NN cord-276616-odmnvv7m 1 32 : : : cord-276616-odmnvv7m 2 1 Vet vet JJ cord-276616-odmnvv7m 2 2 Res res JJ cord-276616-odmnvv7m 2 3 Commun commun NN cord-276616-odmnvv7m 2 4 DOI doi NN cord-276616-odmnvv7m 2 5 : : : cord-276616-odmnvv7m 3 1 10.1007 10.1007 CD cord-276616-odmnvv7m 3 2 / / SYM cord-276616-odmnvv7m 3 3 bf01839302 bf01839302 NN cord-276616-odmnvv7m 3 4 sha sha NNP cord-276616-odmnvv7m 3 5 : : : cord-276616-odmnvv7m 3 6 d4f3362e2820d61ad82b456b927b54c32b76f015 d4f3362e2820d61ad82b456b927b54c32b76f015 NNP cord-276616-odmnvv7m 3 7 doc_id doc_id CD cord-276616-odmnvv7m 3 8 : : : cord-276616-odmnvv7m 3 9 276616 276616 CD cord-276616-odmnvv7m 3 10 cord_uid cord_uid NNS cord-276616-odmnvv7m 3 11 : : : cord-276616-odmnvv7m 4 1 odmnvv7 odmnvv7 NN cord-276616-odmnvv7m 4 2 m m CD cord-276616-odmnvv7m 5 1 The the DT cord-276616-odmnvv7m 5 2 transmissible transmissible JJ cord-276616-odmnvv7m 5 3 spongiform spongiform JJ cord-276616-odmnvv7m 5 4 encephalopathies encephalopathy NNS cord-276616-odmnvv7m 5 5 of of IN cord-276616-odmnvv7m 5 6 domesticated domesticated JJ cord-276616-odmnvv7m 5 7 animals animal NNS cord-276616-odmnvv7m 5 8 , , , cord-276616-odmnvv7m 5 9 scrapie scrapie NN cord-276616-odmnvv7m 5 10 in in IN cord-276616-odmnvv7m 5 11 - - HYPH cord-276616-odmnvv7m 5 12 sheep sheep NN cord-276616-odmnvv7m 5 13 and and CC cord-276616-odmnvv7m 5 14 bovine bovine JJ cord-276616-odmnvv7m 5 15 spongiform spongiform JJ cord-276616-odmnvv7m 5 16 encephalopathy encephalopathy NN cord-276616-odmnvv7m 5 17 ( ( -LRB- cord-276616-odmnvv7m 5 18 BSE BSE NNP cord-276616-odmnvv7m 5 19 ) ) -RRB- cord-276616-odmnvv7m 5 20 , , , cord-276616-odmnvv7m 5 21 and and CC cord-276616-odmnvv7m 5 22 transmissible transmissible JJ cord-276616-odmnvv7m 5 23 mink mink NN cord-276616-odmnvv7m 5 24 encephalopathy encephalopathy NN cord-276616-odmnvv7m 5 25 are be VBP cord-276616-odmnvv7m 5 26 more more JJR cord-276616-odmnvv7m 5 27 than than IN cord-276616-odmnvv7m 5 28 a a DT cord-276616-odmnvv7m 5 29 scientific scientific JJ cord-276616-odmnvv7m 5 30 curiosity curiosity NN cord-276616-odmnvv7m 5 31 ; ; : cord-276616-odmnvv7m 5 32 under under IN cord-276616-odmnvv7m 5 33 certain certain JJ cord-276616-odmnvv7m 5 34 circumstances circumstance NNS cord-276616-odmnvv7m 5 35 their -PRON- PRP$ cord-276616-odmnvv7m 5 36 impact impact NN cord-276616-odmnvv7m 5 37 on on IN cord-276616-odmnvv7m 5 38 commercial commercial JJ cord-276616-odmnvv7m 5 39 activities activity NNS cord-276616-odmnvv7m 5 40 can can MD cord-276616-odmnvv7m 5 41 be be VB cord-276616-odmnvv7m 5 42 calamitous calamitous JJ cord-276616-odmnvv7m 5 43 . . . cord-276616-odmnvv7m 6 1 Knowledge knowledge NN cord-276616-odmnvv7m 6 2 of of IN cord-276616-odmnvv7m 6 3 their -PRON- PRP$ cord-276616-odmnvv7m 6 4 causation causation NN cord-276616-odmnvv7m 6 5 and and CC cord-276616-odmnvv7m 6 6 pathogenesis pathogenesis NN cord-276616-odmnvv7m 6 7 is be VBZ cord-276616-odmnvv7m 6 8 still still RB cord-276616-odmnvv7m 6 9 rudimentary rudimentary JJ cord-276616-odmnvv7m 6 10 , , , cord-276616-odmnvv7m 6 11 but but CC cord-276616-odmnvv7m 6 12 many many JJ cord-276616-odmnvv7m 6 13 consider consider VBP cord-276616-odmnvv7m 6 14 than than IN cord-276616-odmnvv7m 6 15 an an DT cord-276616-odmnvv7m 6 16 unconventional unconventional JJ cord-276616-odmnvv7m 6 17 agent agent NN cord-276616-odmnvv7m 6 18 , , , cord-276616-odmnvv7m 6 19 the the DT cord-276616-odmnvv7m 6 20 prion prion NN cord-276616-odmnvv7m 6 21 ( ( -LRB- cord-276616-odmnvv7m 6 22 a a DT cord-276616-odmnvv7m 6 23 brain brain NN cord-276616-odmnvv7m 6 24 protein protein NN cord-276616-odmnvv7m 6 25 , , , cord-276616-odmnvv7m 6 26 PrP prp NN cord-276616-odmnvv7m 6 27 ) ) -RRB- cord-276616-odmnvv7m 6 28 , , , cord-276616-odmnvv7m 6 29 that that DT cord-276616-odmnvv7m 6 30 is be VBZ cord-276616-odmnvv7m 6 31 not not RB cord-276616-odmnvv7m 6 32 associated associate VBN cord-276616-odmnvv7m 6 33 with with IN cord-276616-odmnvv7m 6 34 nucleic nucleic JJ cord-276616-odmnvv7m 6 35 acid acid NN cord-276616-odmnvv7m 6 36 is be VBZ cord-276616-odmnvv7m 6 37 involved involve VBN cord-276616-odmnvv7m 6 38 in in IN cord-276616-odmnvv7m 6 39 both both DT cord-276616-odmnvv7m 6 40 . . . cord-276616-odmnvv7m 7 1 Others other NNS cord-276616-odmnvv7m 7 2 believe believe VBP cord-276616-odmnvv7m 7 3 that that IN cord-276616-odmnvv7m 7 4 conventional conventional JJ cord-276616-odmnvv7m 7 5 viruses virus NNS cord-276616-odmnvv7m 7 6 , , , cord-276616-odmnvv7m 7 7 which which WDT cord-276616-odmnvv7m 7 8 replicate replicate VBP cord-276616-odmnvv7m 7 9 by by IN cord-276616-odmnvv7m 7 10 virtue virtue NN cord-276616-odmnvv7m 7 11 of of IN cord-276616-odmnvv7m 7 12 their -PRON- PRP$ cord-276616-odmnvv7m 7 13 nucleic nucleic JJ cord-276616-odmnvv7m 7 14 acid acid NN cord-276616-odmnvv7m 7 15 - - HYPH cord-276616-odmnvv7m 7 16 defined define VBN cord-276616-odmnvv7m 7 17 genes gene NNS cord-276616-odmnvv7m 7 18 , , , cord-276616-odmnvv7m 7 19 are be VBP cord-276616-odmnvv7m 7 20 involved involve VBN cord-276616-odmnvv7m 7 21 in in IN cord-276616-odmnvv7m 7 22 the the DT cord-276616-odmnvv7m 7 23 causation causation NN cord-276616-odmnvv7m 7 24 and and CC cord-276616-odmnvv7m 7 25 progression progression NN cord-276616-odmnvv7m 7 26 of of IN cord-276616-odmnvv7m 7 27 the the DT cord-276616-odmnvv7m 7 28 encephalopathies encephalopathy NNS cord-276616-odmnvv7m 7 29 but but CC cord-276616-odmnvv7m 7 30 that that IN cord-276616-odmnvv7m 7 31 technical technical JJ cord-276616-odmnvv7m 7 32 problems problem NNS cord-276616-odmnvv7m 7 33 have have VBP cord-276616-odmnvv7m 7 34 prevented prevent VBN cord-276616-odmnvv7m 7 35 their -PRON- PRP$ cord-276616-odmnvv7m 7 36 identification identification NN cord-276616-odmnvv7m 7 37 . . . cord-276616-odmnvv7m 8 1 Others other NNS cord-276616-odmnvv7m 8 2 postulate postulate VBP cord-276616-odmnvv7m 8 3 even even RB cord-276616-odmnvv7m 8 4 more more RBR cord-276616-odmnvv7m 8 5 exotic exotic JJ cord-276616-odmnvv7m 8 6 causative causative JJ cord-276616-odmnvv7m 8 7 agents agent NNS cord-276616-odmnvv7m 8 8 . . . cord-276616-odmnvv7m 9 1 While while IN cord-276616-odmnvv7m 9 2 this this DT cord-276616-odmnvv7m 9 3 paper paper NN cord-276616-odmnvv7m 9 4 will will MD cord-276616-odmnvv7m 9 5 particularly particularly RB cord-276616-odmnvv7m 9 6 address address VB cord-276616-odmnvv7m 9 7 the the DT cord-276616-odmnvv7m 9 8 possibility possibility NN cord-276616-odmnvv7m 9 9 of of IN cord-276616-odmnvv7m 9 10 a a DT cord-276616-odmnvv7m 9 11 viral viral JJ cord-276616-odmnvv7m 9 12 aetiology aetiology NN cord-276616-odmnvv7m 9 13 for for IN cord-276616-odmnvv7m 9 14 these these DT cord-276616-odmnvv7m 9 15 diseases disease NNS cord-276616-odmnvv7m 9 16 , , , cord-276616-odmnvv7m 9 17 it -PRON- PRP cord-276616-odmnvv7m 9 18 is be VBZ cord-276616-odmnvv7m 9 19 also also RB cord-276616-odmnvv7m 9 20 emphasized emphasize VBN cord-276616-odmnvv7m 9 21 that that IN cord-276616-odmnvv7m 9 22 our -PRON- PRP$ cord-276616-odmnvv7m 9 23 knowledge knowledge NN cord-276616-odmnvv7m 9 24 of of IN cord-276616-odmnvv7m 9 25 the the DT cord-276616-odmnvv7m 9 26 state state NN cord-276616-odmnvv7m 9 27 of of IN cord-276616-odmnvv7m 9 28 the the DT cord-276616-odmnvv7m 9 29 immune immune JJ cord-276616-odmnvv7m 9 30 system system NN cord-276616-odmnvv7m 9 31 in in IN cord-276616-odmnvv7m 9 32 animals animal NNS cord-276616-odmnvv7m 9 33 with with IN cord-276616-odmnvv7m 9 34 encephalopathy encephalopathy NN cord-276616-odmnvv7m 9 35 needs need VBZ cord-276616-odmnvv7m 9 36 broadening broaden VBG cord-276616-odmnvv7m 9 37 . . . cord-276616-odmnvv7m 10 1 There there EX cord-276616-odmnvv7m 10 2 are be VBP cord-276616-odmnvv7m 10 3 remarkable remarkable JJ cord-276616-odmnvv7m 10 4 gaps gap NNS cord-276616-odmnvv7m 10 5 in in IN cord-276616-odmnvv7m 10 6 our -PRON- PRP$ cord-276616-odmnvv7m 10 7 knowledge knowledge NN cord-276616-odmnvv7m 10 8 of of IN cord-276616-odmnvv7m 10 9 the the DT cord-276616-odmnvv7m 10 10 histopathology histopathology NN cord-276616-odmnvv7m 10 11 of of IN cord-276616-odmnvv7m 10 12 these these DT cord-276616-odmnvv7m 10 13 diseases disease NNS cord-276616-odmnvv7m 10 14 , , , cord-276616-odmnvv7m 10 15 particularly particularly RB cord-276616-odmnvv7m 10 16 the the DT cord-276616-odmnvv7m 10 17 nature nature NN cord-276616-odmnvv7m 10 18 of of IN cord-276616-odmnvv7m 10 19 the the DT cord-276616-odmnvv7m 10 20 characteristic characteristic JJ cord-276616-odmnvv7m 10 21 vacuoles vacuole NNS cord-276616-odmnvv7m 10 22 . . . cord-276616-odmnvv7m 11 1 Much much JJ cord-276616-odmnvv7m 11 2 further further JJ cord-276616-odmnvv7m 11 3 work work NN cord-276616-odmnvv7m 11 4 is be VBZ cord-276616-odmnvv7m 11 5 needed need VBN cord-276616-odmnvv7m 11 6 on on IN cord-276616-odmnvv7m 11 7 the the DT cord-276616-odmnvv7m 11 8 biochemical biochemical JJ cord-276616-odmnvv7m 11 9 changes change NNS cord-276616-odmnvv7m 11 10 in in IN cord-276616-odmnvv7m 11 11 the the DT cord-276616-odmnvv7m 11 12 brain brain NN cord-276616-odmnvv7m 11 13 and and CC cord-276616-odmnvv7m 11 14 the the DT cord-276616-odmnvv7m 11 15 serum serum NN cord-276616-odmnvv7m 11 16 , , , cord-276616-odmnvv7m 11 17 particularly particularly RB cord-276616-odmnvv7m 11 18 of of IN cord-276616-odmnvv7m 11 19 the the DT cord-276616-odmnvv7m 11 20 latter latter JJ cord-276616-odmnvv7m 11 21 as as IN cord-276616-odmnvv7m 11 22 it -PRON- PRP cord-276616-odmnvv7m 11 23 could could MD cord-276616-odmnvv7m 11 24 lead lead VB cord-276616-odmnvv7m 11 25 to to IN cord-276616-odmnvv7m 11 26 an an DT cord-276616-odmnvv7m 11 27 additional additional JJ cord-276616-odmnvv7m 11 28 means mean NNS cord-276616-odmnvv7m 11 29 of of IN cord-276616-odmnvv7m 11 30 recognizing recognize VBG cord-276616-odmnvv7m 11 31 clinical clinical JJ cord-276616-odmnvv7m 11 32 cases case NNS cord-276616-odmnvv7m 11 33 without without IN cord-276616-odmnvv7m 11 34 waiting wait VBG cord-276616-odmnvv7m 11 35 for for IN cord-276616-odmnvv7m 11 36 the the DT cord-276616-odmnvv7m 11 37 animal animal NN cord-276616-odmnvv7m 11 38 to to TO cord-276616-odmnvv7m 11 39 die die VB cord-276616-odmnvv7m 11 40 with with IN cord-276616-odmnvv7m 11 41 subsequent subsequent JJ cord-276616-odmnvv7m 11 42 examination examination NN cord-276616-odmnvv7m 11 43 of of IN cord-276616-odmnvv7m 11 44 the the DT cord-276616-odmnvv7m 11 45 brain brain NN cord-276616-odmnvv7m 11 46 for for IN cord-276616-odmnvv7m 11 47 characteristic characteristic JJ cord-276616-odmnvv7m 11 48 lesions lesion NNS cord-276616-odmnvv7m 11 49 and and CC cord-276616-odmnvv7m 11 50 the the DT cord-276616-odmnvv7m 11 51 presence presence NN cord-276616-odmnvv7m 11 52 of of IN cord-276616-odmnvv7m 11 53 protease protease NN cord-276616-odmnvv7m 11 54 - - HYPH cord-276616-odmnvv7m 11 55 K k NN cord-276616-odmnvv7m 11 56 - - HYPH cord-276616-odmnvv7m 11 57 resistant resistant JJ cord-276616-odmnvv7m 11 58 PrP. PrP. NNP cord-276616-odmnvv7m 12 1 In in IN cord-276616-odmnvv7m 12 2 the the DT cord-276616-odmnvv7m 12 3 transmissible transmissible JJ cord-276616-odmnvv7m 12 4 spongiform spongiform JJ cord-276616-odmnvv7m 12 5 encephalopathies encephalopathy NNS cord-276616-odmnvv7m 12 6 ( ( -LRB- cord-276616-odmnvv7m 12 7 Kimberlin Kimberlin NNP cord-276616-odmnvv7m 12 8 , , , cord-276616-odmnvv7m 12 9 1990 1990 CD cord-276616-odmnvv7m 12 10 ) ) -RRB- cord-276616-odmnvv7m 12 11 , , , cord-276616-odmnvv7m 12 12 a a DT cord-276616-odmnvv7m 12 13 variety variety NN cord-276616-odmnvv7m 12 14 of of IN cord-276616-odmnvv7m 12 15 neurological neurological JJ cord-276616-odmnvv7m 12 16 signs sign NNS cord-276616-odmnvv7m 12 17 follow follow VBP cord-276616-odmnvv7m 12 18 non non JJ cord-276616-odmnvv7m 12 19 - - JJ cord-276616-odmnvv7m 12 20 inflammatory inflammatory JJ cord-276616-odmnvv7m 12 21 , , , cord-276616-odmnvv7m 12 22 vacuolar vacuolar NN cord-276616-odmnvv7m 12 23 , , , cord-276616-odmnvv7m 12 24 degeneration degeneration NN cord-276616-odmnvv7m 12 25 in in IN cord-276616-odmnvv7m 12 26 the the DT cord-276616-odmnvv7m 12 27 brain brain NN cord-276616-odmnvv7m 12 28 and and CC cord-276616-odmnvv7m 12 29 spinal spinal JJ cord-276616-odmnvv7m 12 30 cord cord NN cord-276616-odmnvv7m 12 31 . . . cord-276616-odmnvv7m 13 1 Accumulations accumulation NNS cord-276616-odmnvv7m 13 2 of of IN cord-276616-odmnvv7m 13 3 amyloid amyloid NN cord-276616-odmnvv7m 13 4 and and CC cord-276616-odmnvv7m 13 5 other other JJ cord-276616-odmnvv7m 13 6 proteinaceous proteinaceous JJ cord-276616-odmnvv7m 13 7 fibrils fibril NNS cord-276616-odmnvv7m 13 8 occur occur VBP cord-276616-odmnvv7m 13 9 . . . cord-276616-odmnvv7m 14 1 These these DT cord-276616-odmnvv7m 14 2 fibrillar fibrillar NNP cord-276616-odmnvv7m 14 3 accumulations accumulation NNS cord-276616-odmnvv7m 14 4 can can MD cord-276616-odmnvv7m 14 5 form form VB cord-276616-odmnvv7m 14 6 plaques plaque NNS cord-276616-odmnvv7m 14 7 similar similar JJ cord-276616-odmnvv7m 14 8 in in IN cord-276616-odmnvv7m 14 9 appearance appearance NN cord-276616-odmnvv7m 14 10 to to IN cord-276616-odmnvv7m 14 11 those those DT cord-276616-odmnvv7m 14 12 seen see VBN cord-276616-odmnvv7m 14 13 in in IN cord-276616-odmnvv7m 14 14 Alzheimer Alzheimer NNP cord-276616-odmnvv7m 14 15 's 's POS cord-276616-odmnvv7m 14 16 disease disease NN cord-276616-odmnvv7m 14 17 in in IN cord-276616-odmnvv7m 14 18 man man NN cord-276616-odmnvv7m 14 19 . . . cord-276616-odmnvv7m 15 1 After after IN cord-276616-odmnvv7m 15 2 a a DT cord-276616-odmnvv7m 15 3 very very RB cord-276616-odmnvv7m 15 4 long long JJ cord-276616-odmnvv7m 15 5 quiescent quiescent JJ cord-276616-odmnvv7m 15 6 latent latent JJ cord-276616-odmnvv7m 15 7 period period NN cord-276616-odmnvv7m 15 8 following follow VBG cord-276616-odmnvv7m 15 9 infection infection NN cord-276616-odmnvv7m 15 10 , , , cord-276616-odmnvv7m 15 11 the the DT cord-276616-odmnvv7m 15 12 spongiform spongiform JJ cord-276616-odmnvv7m 15 13 encephalopathies encephalopathy NNS cord-276616-odmnvv7m 15 14 progress progress VBP cord-276616-odmnvv7m 15 15 very very RB cord-276616-odmnvv7m 15 16 slowly slowly RB cord-276616-odmnvv7m 15 17 over over IN cord-276616-odmnvv7m 15 18 a a DT cord-276616-odmnvv7m 15 19 period period NN cord-276616-odmnvv7m 15 20 of of IN cord-276616-odmnvv7m 15 21 weeks week NNS cord-276616-odmnvv7m 15 22 to to IN cord-276616-odmnvv7m 15 23 months month NNS cord-276616-odmnvv7m 15 24 . . . cord-276616-odmnvv7m 16 1 This this DT cord-276616-odmnvv7m 16 2 group group NN cord-276616-odmnvv7m 16 3 of of IN cord-276616-odmnvv7m 16 4 diseases disease NNS cord-276616-odmnvv7m 16 5 provides provide VBZ cord-276616-odmnvv7m 16 6 a a DT cord-276616-odmnvv7m 16 7 good good JJ cord-276616-odmnvv7m 16 8 example example NN cord-276616-odmnvv7m 16 9 of of IN cord-276616-odmnvv7m 16 10 disastrous disastrous JJ cord-276616-odmnvv7m 16 11 events event NNS cord-276616-odmnvv7m 16 12 in in IN cord-276616-odmnvv7m 16 13 the the DT cord-276616-odmnvv7m 16 14 field field NN cord-276616-odmnvv7m 16 15 of of IN cord-276616-odmnvv7m 16 16 veterinary veterinary JJ cord-276616-odmnvv7m 16 17 medicine medicine NN cord-276616-odmnvv7m 16 18 that that WDT cord-276616-odmnvv7m 16 19 have have VBP cord-276616-odmnvv7m 16 20 put put VBN cord-276616-odmnvv7m 16 21 into into IN cord-276616-odmnvv7m 16 22 question question NN cord-276616-odmnvv7m 16 23 all all PDT cord-276616-odmnvv7m 16 24 our -PRON- PRP$ cord-276616-odmnvv7m 16 25 current current JJ cord-276616-odmnvv7m 16 26 concepts concept NNS cord-276616-odmnvv7m 16 27 of of IN cord-276616-odmnvv7m 16 28 the the DT cord-276616-odmnvv7m 16 29 genesis genesis NN cord-276616-odmnvv7m 16 30 of of IN cord-276616-odmnvv7m 16 31 disease disease NNP cord-276616-odmnvv7m 16 32 . . . cord-276616-odmnvv7m 17 1 These these DT cord-276616-odmnvv7m 17 2 events event NNS cord-276616-odmnvv7m 17 3 have have VBP cord-276616-odmnvv7m 17 4 also also RB cord-276616-odmnvv7m 17 5 had have VBN cord-276616-odmnvv7m 17 6 the the DT cord-276616-odmnvv7m 17 7 positive positive JJ cord-276616-odmnvv7m 17 8 effect effect NN cord-276616-odmnvv7m 17 9 of of IN cord-276616-odmnvv7m 17 10 focusing focus VBG cord-276616-odmnvv7m 17 11 attention attention NN cord-276616-odmnvv7m 17 12 on on IN cord-276616-odmnvv7m 17 13 enormous enormous JJ cord-276616-odmnvv7m 17 14 gaps gap NNS cord-276616-odmnvv7m 17 15 in in IN cord-276616-odmnvv7m 17 16 our -PRON- PRP$ cord-276616-odmnvv7m 17 17 knowledge knowledge NN cord-276616-odmnvv7m 17 18 and and CC cord-276616-odmnvv7m 17 19 stimulating stimulate VBG cord-276616-odmnvv7m 17 20 a a DT cord-276616-odmnvv7m 17 21 great great JJ cord-276616-odmnvv7m 17 22 deal deal NN cord-276616-odmnvv7m 17 23 of of IN cord-276616-odmnvv7m 17 24 research research NN cord-276616-odmnvv7m 17 25 . . . cord-276616-odmnvv7m 18 1 Reference reference NN cord-276616-odmnvv7m 18 2 to to IN cord-276616-odmnvv7m 18 3 older old JJR cord-276616-odmnvv7m 18 4 literature literature NN cord-276616-odmnvv7m 18 5 on on IN cord-276616-odmnvv7m 18 6 scrapie scrapie NN cord-276616-odmnvv7m 18 7 can can MD cord-276616-odmnvv7m 18 8 be be VB cord-276616-odmnvv7m 18 9 made make VBN cord-276616-odmnvv7m 18 10 in in IN cord-276616-odmnvv7m 18 11 books book NNS cord-276616-odmnvv7m 18 12 edited edit VBN cord-276616-odmnvv7m 18 13 by by IN cord-276616-odmnvv7m 18 14 Kimberlin Kimberlin NNP cord-276616-odmnvv7m 18 15 ( ( -LRB- cord-276616-odmnvv7m 18 16 1976a 1976a CD cord-276616-odmnvv7m 18 17 ) ) -RRB- cord-276616-odmnvv7m 18 18 and and CC cord-276616-odmnvv7m 18 19 Prusiner Prusiner NNP cord-276616-odmnvv7m 18 20 and and CC cord-276616-odmnvv7m 18 21 Hadlow Hadlow NNP cord-276616-odmnvv7m 18 22 ( ( -LRB- cord-276616-odmnvv7m 18 23 1979 1979 CD cord-276616-odmnvv7m 18 24 ) ) -RRB- cord-276616-odmnvv7m 18 25 . . . cord-276616-odmnvv7m 19 1 The the DT cord-276616-odmnvv7m 19 2 advent advent NN cord-276616-odmnvv7m 19 3 of of IN cord-276616-odmnvv7m 19 4 BSE BSE NNP cord-276616-odmnvv7m 19 5 in in IN cord-276616-odmnvv7m 19 6 Britain Britain NNP cord-276616-odmnvv7m 19 7 , , , cord-276616-odmnvv7m 19 8 starting start VBG cord-276616-odmnvv7m 19 9 in in IN cord-276616-odmnvv7m 19 10 the the DT cord-276616-odmnvv7m 19 11 1980s 1980 NNS cord-276616-odmnvv7m 19 12 , , , cord-276616-odmnvv7m 19 13 resulted result VBD cord-276616-odmnvv7m 19 14 in in IN cord-276616-odmnvv7m 19 15 the the DT cord-276616-odmnvv7m 19 16 appearance appearance NN cord-276616-odmnvv7m 19 17 of of IN cord-276616-odmnvv7m 19 18 numerous numerous JJ cord-276616-odmnvv7m 19 19 articles article NNS cord-276616-odmnvv7m 19 20 on on IN cord-276616-odmnvv7m 19 21 the the DT cord-276616-odmnvv7m 19 22 significance significance NN cord-276616-odmnvv7m 19 23 of of IN cord-276616-odmnvv7m 19 24 the the DT cord-276616-odmnvv7m 19 25 spongiform spongiform JJ cord-276616-odmnvv7m 19 26 encephalopathies encephalopathy NNS cord-276616-odmnvv7m 19 27 . . . cord-276616-odmnvv7m 20 1 These these DT cord-276616-odmnvv7m 20 2 include include VBP cord-276616-odmnvv7m 20 3 a a DT cord-276616-odmnvv7m 20 4 number number NN cord-276616-odmnvv7m 20 5 of of IN cord-276616-odmnvv7m 20 6 more more JJR cord-276616-odmnvv7m 20 7 recent recent JJ cord-276616-odmnvv7m 20 8 reviews review NNS cord-276616-odmnvv7m 20 9 ( ( -LRB- cord-276616-odmnvv7m 20 10 Little little JJ cord-276616-odmnvv7m 20 11 and and CC cord-276616-odmnvv7m 20 12 Thorsen Thorsen NNP cord-276616-odmnvv7m 20 13 , , , cord-276616-odmnvv7m 20 14 1989 1989 CD cord-276616-odmnvv7m 20 15 ; ; : cord-276616-odmnvv7m 20 16 Chesebro Chesebro NNP cord-276616-odmnvv7m 20 17 , , , cord-276616-odmnvv7m 20 18 1991 1991 CD cord-276616-odmnvv7m 20 19 ; ; : cord-276616-odmnvv7m 20 20 Powell Powell NNP cord-276616-odmnvv7m 20 21 , , , cord-276616-odmnvv7m 20 22 1993 1993 CD cord-276616-odmnvv7m 20 23 ) ) -RRB- cord-276616-odmnvv7m 20 24 . . . cord-276616-odmnvv7m 21 1 Scrapie Scrapie NNP cord-276616-odmnvv7m 21 2 , , , cord-276616-odmnvv7m 21 3 a a DT cord-276616-odmnvv7m 21 4 disease disease NN cord-276616-odmnvv7m 21 5 of of IN cord-276616-odmnvv7m 21 6 sheep sheep NN cord-276616-odmnvv7m 21 7 , , , cord-276616-odmnvv7m 21 8 was be VBD cord-276616-odmnvv7m 21 9 the the DT cord-276616-odmnvv7m 21 10 first first JJ cord-276616-odmnvv7m 21 11 of of IN cord-276616-odmnvv7m 21 12 these these DT cord-276616-odmnvv7m 21 13 diseases disease NNS cord-276616-odmnvv7m 21 14 to to TO cord-276616-odmnvv7m 21 15 attract attract VB cord-276616-odmnvv7m 21 16 enough enough JJ cord-276616-odmnvv7m 21 17 attention attention NN cord-276616-odmnvv7m 21 18 to to TO cord-276616-odmnvv7m 21 19 stimulate stimulate VB cord-276616-odmnvv7m 21 20 research research NN cord-276616-odmnvv7m 21 21 into into IN cord-276616-odmnvv7m 21 22 its -PRON- PRP$ cord-276616-odmnvv7m 21 23 causation causation NN cord-276616-odmnvv7m 21 24 and and CC cord-276616-odmnvv7m 21 25 recognition recognition NN cord-276616-odmnvv7m 21 26 . . . cord-276616-odmnvv7m 22 1 The the DT cord-276616-odmnvv7m 22 2 disease disease NN cord-276616-odmnvv7m 22 3 had have VBD cord-276616-odmnvv7m 22 4 been be VBN cord-276616-odmnvv7m 22 5 recognized recognize VBN cord-276616-odmnvv7m 22 6 for for IN cord-276616-odmnvv7m 22 7 some some DT cord-276616-odmnvv7m 22 8 time time NN cord-276616-odmnvv7m 22 9 but but CC cord-276616-odmnvv7m 22 10 it -PRON- PRP cord-276616-odmnvv7m 22 11 did do VBD cord-276616-odmnvv7m 22 12 not not RB cord-276616-odmnvv7m 22 13 become become VB cord-276616-odmnvv7m 22 14 the the DT cord-276616-odmnvv7m 22 15 subject subject NN cord-276616-odmnvv7m 22 16 of of IN cord-276616-odmnvv7m 22 17 experimental experimental JJ cord-276616-odmnvv7m 22 18 work work NN cord-276616-odmnvv7m 22 19 until until IN cord-276616-odmnvv7m 22 20 the the DT cord-276616-odmnvv7m 22 21 1930s 1930 NNS cord-276616-odmnvv7m 22 22 , , , cord-276616-odmnvv7m 22 23 when when WRB cord-276616-odmnvv7m 22 24 CuiU6 CuiU6 NNP cord-276616-odmnvv7m 22 25 and and CC cord-276616-odmnvv7m 22 26 Chelle Chelle NNP cord-276616-odmnvv7m 22 27 , , , cord-276616-odmnvv7m 22 28 cited cite VBN cord-276616-odmnvv7m 22 29 by by IN cord-276616-odmnvv7m 22 30 Gordon Gordon NNP cord-276616-odmnvv7m 22 31 ( ( -LRB- cord-276616-odmnvv7m 22 32 1946 1946 CD cord-276616-odmnvv7m 22 33 ) ) -RRB- cord-276616-odmnvv7m 22 34 , , , cord-276616-odmnvv7m 22 35 reported report VBN cord-276616-odmnvv7m 22 36 on on IN cord-276616-odmnvv7m 22 37 its -PRON- PRP$ cord-276616-odmnvv7m 22 38 transmission transmission NN cord-276616-odmnvv7m 22 39 . . . cord-276616-odmnvv7m 23 1 Its -PRON- PRP$ cord-276616-odmnvv7m 23 2 accidental accidental JJ cord-276616-odmnvv7m 23 3 transmission transmission NN cord-276616-odmnvv7m 23 4 during during IN cord-276616-odmnvv7m 23 5 large large JJ cord-276616-odmnvv7m 23 6 - - HYPH cord-276616-odmnvv7m 23 7 scale scale NN cord-276616-odmnvv7m 23 8 field field NN cord-276616-odmnvv7m 23 9 trials trial NNS cord-276616-odmnvv7m 23 10 of of IN cord-276616-odmnvv7m 23 11 vaccination vaccination NN cord-276616-odmnvv7m 23 12 of of IN cord-276616-odmnvv7m 23 13 sheep sheep NN cord-276616-odmnvv7m 23 14 against against IN cord-276616-odmnvv7m 23 15 louping louping NN cord-276616-odmnvv7m 23 16 - - HYPH cord-276616-odmnvv7m 23 17 ill ill NNP cord-276616-odmnvv7m 23 18 also also RB cord-276616-odmnvv7m 23 19 gave give VBD cord-276616-odmnvv7m 23 20 impetus impetus NN cord-276616-odmnvv7m 23 21 to to TO cord-276616-odmnvv7m 23 22 research research VB cord-276616-odmnvv7m 23 23 on on IN cord-276616-odmnvv7m 23 24 this this DT cord-276616-odmnvv7m 23 25 disease disease NN cord-276616-odmnvv7m 23 26 1 1 CD cord-276616-odmnvv7m 23 27 .. .. . cord-276616-odmnvv7m 24 1 The the DT cord-276616-odmnvv7m 24 2 vaccine vaccine NN cord-276616-odmnvv7m 24 3 had have VBD cord-276616-odmnvv7m 24 4 been be VBN cord-276616-odmnvv7m 24 5 prepared prepare VBN cord-276616-odmnvv7m 24 6 from from IN cord-276616-odmnvv7m 24 7 formaliuized formaliuized JJ cord-276616-odmnvv7m 24 8 brain brain NN cord-276616-odmnvv7m 24 9 and and CC cord-276616-odmnvv7m 24 10 spleen spleen NN cord-276616-odmnvv7m 24 11 suspensions suspension NNS cord-276616-odmnvv7m 24 12 from from IN cord-276616-odmnvv7m 24 13 louping loupe VBG cord-276616-odmnvv7m 24 14 - - HYPH cord-276616-odmnvv7m 24 15 ill ill RB cord-276616-odmnvv7m 24 16 - - HYPH cord-276616-odmnvv7m 24 17 infected infected JJ cord-276616-odmnvv7m 24 18 yearling yearling NN cord-276616-odmnvv7m 24 19 sheep sheep NN cord-276616-odmnvv7m 24 20 ( ( -LRB- cord-276616-odmnvv7m 24 21 Gordon Gordon NNP cord-276616-odmnvv7m 24 22 , , , cord-276616-odmnvv7m 24 23 1946 1946 CD cord-276616-odmnvv7m 24 24 ) ) -RRB- cord-276616-odmnvv7m 24 25 . . . cord-276616-odmnvv7m 25 1 Starting start VBG cord-276616-odmnvv7m 25 2 2½ 2½ CD cord-276616-odmnvv7m 25 3 years year NNS cord-276616-odmnvv7m 25 4 after after IN cord-276616-odmnvv7m 25 5 vaccination vaccination NN cord-276616-odmnvv7m 25 6 , , , cord-276616-odmnvv7m 25 7 scrapie scrapie NN cord-276616-odmnvv7m 25 8 started start VBD cord-276616-odmnvv7m 25 9 to to TO cord-276616-odmnvv7m 25 10 appear appear VB cord-276616-odmnvv7m 25 11 in in IN cord-276616-odmnvv7m 25 12 animals animal NNS cord-276616-odmnvv7m 25 13 of of IN cord-276616-odmnvv7m 25 14 all all DT cord-276616-odmnvv7m 25 15 breeds breed NNS cord-276616-odmnvv7m 25 16 vaccinated vaccinate VBN cord-276616-odmnvv7m 25 17 with with IN cord-276616-odmnvv7m 25 18 one one CD cord-276616-odmnvv7m 25 19 lot lot NN cord-276616-odmnvv7m 25 20 of of IN cord-276616-odmnvv7m 25 21 vaccine vaccine NN cord-276616-odmnvv7m 25 22 . . . cord-276616-odmnvv7m 26 1 This this DT cord-276616-odmnvv7m 26 2 unfortunate unfortunate JJ cord-276616-odmnvv7m 26 3 experience experience NN cord-276616-odmnvv7m 26 4 prompted prompt VBD cord-276616-odmnvv7m 26 5 transmission transmission NN cord-276616-odmnvv7m 26 6 studies study NNS cord-276616-odmnvv7m 26 7 designed design VBN cord-276616-odmnvv7m 26 8 to to TO cord-276616-odmnvv7m 26 9 determine determine VB cord-276616-odmnvv7m 26 10 the the DT cord-276616-odmnvv7m 26 11 nature nature NN cord-276616-odmnvv7m 26 12 of of IN cord-276616-odmnvv7m 26 13 the the DT cord-276616-odmnvv7m 26 14 infective infective JJ cord-276616-odmnvv7m 26 15 agent agent NN cord-276616-odmnvv7m 26 16 and and CC cord-276616-odmnvv7m 26 17 the the DT cord-276616-odmnvv7m 26 18 pathogenesis pathogenesis NN cord-276616-odmnvv7m 26 19 of of IN cord-276616-odmnvv7m 26 20 the the DT cord-276616-odmnvv7m 26 21 disease disease NN cord-276616-odmnvv7m 26 22 in in IN cord-276616-odmnvv7m 26 23 sheep sheep NN cord-276616-odmnvv7m 26 24 . . . cord-276616-odmnvv7m 27 1 Conclusions conclusion NNS cord-276616-odmnvv7m 27 2 drawn draw VBN cord-276616-odmnvv7m 27 3 from from IN cord-276616-odmnvv7m 27 4 the the DT cord-276616-odmnvv7m 27 5 vaccination vaccination NN cord-276616-odmnvv7m 27 6 trials trial NNS cord-276616-odmnvv7m 27 7 and and CC cord-276616-odmnvv7m 27 8 transmission transmission NN cord-276616-odmnvv7m 27 9 experiments experiment NNS cord-276616-odmnvv7m 27 10 were be VBD cord-276616-odmnvv7m 27 11 that that IN cord-276616-odmnvv7m 27 12 ~crapie ~crapie NNP cord-276616-odmnvv7m 27 13 , , , cord-276616-odmnvv7m 27 14 given give VBN cord-276616-odmnvv7m 27 15 by by IN cord-276616-odmnvv7m 27 16 subcutaneous subcutaneous JJ cord-276616-odmnvv7m 27 17 inoculation inoculation NN cord-276616-odmnvv7m 27 18 , , , cord-276616-odmnvv7m 27 19 had have VBD cord-276616-odmnvv7m 27 20 a a DT cord-276616-odmnvv7m 27 21 latent latent JJ cord-276616-odmnvv7m 27 22 period period NN cord-276616-odmnvv7m 27 23 of of IN cord-276616-odmnvv7m 27 24 2 2 CD cord-276616-odmnvv7m 27 25 years year NNS cord-276616-odmnvv7m 27 26 and and CC cord-276616-odmnvv7m 27 27 longer long RBR cord-276616-odmnvv7m 27 28 ; ; : cord-276616-odmnvv7m 27 29 that that IN cord-276616-odmnvv7m 27 30 the the DT cord-276616-odmnvv7m 27 31 infective infective JJ cord-276616-odmnvv7m 27 32 agent agent NN cord-276616-odmnvv7m 27 33 was be VBD cord-276616-odmnvv7m 27 34 resistant resistant JJ cord-276616-odmnvv7m 27 35 to to IN cord-276616-odmnvv7m 27 36 0.35 0.35 CD cord-276616-odmnvv7m 27 37 % % NN cord-276616-odmnvv7m 27 38 formalin formalin NN cord-276616-odmnvv7m 27 39 ; ; : cord-276616-odmnvv7m 27 40 that that IN cord-276616-odmnvv7m 27 41 the the DT cord-276616-odmnvv7m 27 42 disease disease NN cord-276616-odmnvv7m 27 43 appeared appear VBD cord-276616-odmnvv7m 27 44 more more RBR cord-276616-odmnvv7m 27 45 quickly quickly RB cord-276616-odmnvv7m 27 46 and and CC cord-276616-odmnvv7m 27 47 in in IN cord-276616-odmnvv7m 27 48 a a DT cord-276616-odmnvv7m 27 49 higher high JJR cord-276616-odmnvv7m 27 50 percentage percentage NN cord-276616-odmnvv7m 27 51 of of IN cord-276616-odmnvv7m 27 52 recipients recipient NNS cord-276616-odmnvv7m 27 53 following follow VBG cord-276616-odmnvv7m 27 54 intracerebral intracerebral NNP cord-276616-odmnvv7m 27 55 than than IN cord-276616-odmnvv7m 27 56 following follow VBG cord-276616-odmnvv7m 27 57 ~ ~ NFP cord-276616-odmnvv7m 27 58 subcutaneous subcutaneous JJ cord-276616-odmnvv7m 27 59 injection injection NN cord-276616-odmnvv7m 27 60 ; ; : cord-276616-odmnvv7m 27 61 and and CC cord-276616-odmnvv7m 27 62 that that IN cord-276616-odmnvv7m 27 63 the the DT cord-276616-odmnvv7m 27 64 causative causative JJ cord-276616-odmnvv7m 27 65 agent agent NN cord-276616-odmnvv7m 27 66 was be VBD cord-276616-odmnvv7m 27 67 probably probably RB cord-276616-odmnvv7m 27 68 a a DT cord-276616-odmnvv7m 27 69 filtrable filtrable JJ cord-276616-odmnvv7m 27 70 virus virus NN cord-276616-odmnvv7m 27 71 . . . cord-276616-odmnvv7m 28 1 A a DT cord-276616-odmnvv7m 28 2 similar similar JJ cord-276616-odmnvv7m 28 3 disease disease NN cord-276616-odmnvv7m 28 4 to to IN cord-276616-odmnvv7m 28 5 scrapie scrapie NN cord-276616-odmnvv7m 28 6 is be VBZ cord-276616-odmnvv7m 28 7 bovine bovine JJ cord-276616-odmnvv7m 28 8 spongiform spongiform JJ cord-276616-odmnvv7m 28 9 encephalopathy encephalopathy NN cord-276616-odmnvv7m 28 10 ( ( -LRB- cord-276616-odmnvv7m 28 11 BSE BSE NNP cord-276616-odmnvv7m 28 12 ) ) -RRB- cord-276616-odmnvv7m 28 13 , , , cord-276616-odmnvv7m 28 14 of of IN cord-276616-odmnvv7m 28 15 which which WDT cord-276616-odmnvv7m 28 16 the the DT cord-276616-odmnvv7m 28 17 first first JJ cord-276616-odmnvv7m 28 18 ca ca NN cord-276616-odmnvv7m 28 19 ~ ~ NFP cord-276616-odmnvv7m 28 20 e e XX cord-276616-odmnvv7m 28 21 of of IN cord-276616-odmnvv7m 28 22 a a DT cord-276616-odmnvv7m 28 23 major major JJ cord-276616-odmnvv7m 28 24 enzootic enzootic NNP cord-276616-odmnvv7m 28 25 was be VBD cord-276616-odmnvv7m 28 26 confirmed confirm VBN cord-276616-odmnvv7m 28 27 in in IN cord-276616-odmnvv7m 28 28 November November NNP cord-276616-odmnvv7m 28 29 1986 1986 CD cord-276616-odmnvv7m 28 30 in in IN cord-276616-odmnvv7m 28 31 England England NNP cord-276616-odmnvv7m 28 32 ( ( -LRB- cord-276616-odmnvv7m 28 33 Bradley Bradley NNP cord-276616-odmnvv7m 28 34 and and CC cord-276616-odmnvv7m 28 35 Matthews Matthews NNP cord-276616-odmnvv7m 28 36 , , , cord-276616-odmnvv7m 28 37 1992 1992 CD cord-276616-odmnvv7m 28 38 ) ) -RRB- cord-276616-odmnvv7m 28 39 . . . cord-276616-odmnvv7m 29 1 The the DT cord-276616-odmnvv7m 29 2 emergence emergence NN cord-276616-odmnvv7m 29 3 of of IN cord-276616-odmnvv7m 29 4 this this DT cord-276616-odmnvv7m 29 5 disease disease NN cord-276616-odmnvv7m 29 6 was be VBD cord-276616-odmnvv7m 29 7 considered consider VBN cord-276616-odmnvv7m 29 8 to to TO cord-276616-odmnvv7m 29 9 be be VB cord-276616-odmnvv7m 29 10 related relate VBN cord-276616-odmnvv7m 29 11 to to IN cord-276616-odmnvv7m 29 12 the the DT cord-276616-odmnvv7m 29 13 ingestion ingestion NN cord-276616-odmnvv7m 29 14 of of IN cord-276616-odmnvv7m 29 15 meat meat NN cord-276616-odmnvv7m 29 16 and and CC cord-276616-odmnvv7m 29 17 bonemeal bonemeal NN cord-276616-odmnvv7m 29 18 derived derive VBN cord-276616-odmnvv7m 29 19 from from IN cord-276616-odmnvv7m 29 20 ruminant ruminant NN cord-276616-odmnvv7m 29 21 sources source NNS cord-276616-odmnvv7m 29 22 following follow VBG cord-276616-odmnvv7m 29 23 countrywide countrywide JJ cord-276616-odmnvv7m 29 24 changes change NNS cord-276616-odmnvv7m 29 25 in in IN cord-276616-odmnvv7m 29 26 the the DT cord-276616-odmnvv7m 29 27 rendering rendering NN cord-276616-odmnvv7m 29 28 process process NN cord-276616-odmnvv7m 29 29 ( ( -LRB- cord-276616-odmnvv7m 29 30 Wilesmith Wilesmith NNP cord-276616-odmnvv7m 29 31 et et NNP cord-276616-odmnvv7m 29 32 aL aL NNP cord-276616-odmnvv7m 29 33 , , , cord-276616-odmnvv7m 29 34 1991 1991 CD cord-276616-odmnvv7m 29 35 ) ) -RRB- cord-276616-odmnvv7m 29 36 . . . cord-276616-odmnvv7m 30 1 The the DT cord-276616-odmnvv7m 30 2 feeding feeding NN cord-276616-odmnvv7m 30 3 of of IN cord-276616-odmnvv7m 30 4 ruminant ruminant NN cord-276616-odmnvv7m 30 5 - - HYPH cord-276616-odmnvv7m 30 6 derived derive VBN cord-276616-odmnvv7m 30 7 meat meat NN cord-276616-odmnvv7m 30 8 and and CC cord-276616-odmnvv7m 30 9 bonemeal bonemeal NN cord-276616-odmnvv7m 30 10 to to IN cord-276616-odmnvv7m 30 11 cattle cattle NNS cord-276616-odmnvv7m 30 12 in in IN cord-276616-odmnvv7m 30 13 Britain Britain NNP cord-276616-odmnvv7m 30 14 was be VBD cord-276616-odmnvv7m 30 15 stopped stop VBN cord-276616-odmnvv7m 30 16 by by IN cord-276616-odmnvv7m 30 17 law law NN cord-276616-odmnvv7m 30 18 in in IN cord-276616-odmnvv7m 30 19 1988 1988 CD cord-276616-odmnvv7m 30 20 . . . cord-276616-odmnvv7m 31 1 Since since IN cord-276616-odmnvv7m 31 2 the the DT cord-276616-odmnvv7m 31 3 implementation implementation NN cord-276616-odmnvv7m 31 4 of of IN cord-276616-odmnvv7m 31 5 this this DT cord-276616-odmnvv7m 31 6 ban ban NN cord-276616-odmnvv7m 31 7 , , , cord-276616-odmnvv7m 31 8 the the DT cord-276616-odmnvv7m 31 9 occurrence occurrence NN cord-276616-odmnvv7m 31 10 of of IN cord-276616-odmnvv7m 31 11 new new JJ cord-276616-odmnvv7m 31 12 cases case NNS cord-276616-odmnvv7m 31 13 of of IN cord-276616-odmnvv7m 31 14 this this DT cord-276616-odmnvv7m 31 15 disease disease NN cord-276616-odmnvv7m 31 16 in in IN cord-276616-odmnvv7m 31 17 cattle cattle NNS cord-276616-odmnvv7m 31 18 has have VBZ cord-276616-odmnvv7m 31 19 been be VBN cord-276616-odmnvv7m 31 20 reduced reduce VBN cord-276616-odmnvv7m 32 1 ( ( -LRB- cord-276616-odmnvv7m 32 2 Wilesmith Wilesmith NNP cord-276616-odmnvv7m 32 3 and and CC cord-276616-odmnvv7m 32 4 Ryan Ryan NNP cord-276616-odmnvv7m 32 5 , , , cord-276616-odmnvv7m 32 6 1993 1993 CD cord-276616-odmnvv7m 32 7 ) ) -RRB- cord-276616-odmnvv7m 32 8 . . . cord-276616-odmnvv7m 33 1 The the DT cord-276616-odmnvv7m 33 2 BSE BSE NNP cord-276616-odmnvv7m 33 3 outbreak outbreak NN cord-276616-odmnvv7m 33 4 drew draw VBD cord-276616-odmnvv7m 33 5 attention attention NN cord-276616-odmnvv7m 33 6 to to IN cord-276616-odmnvv7m 33 7 spongiform spongiform JJ cord-276616-odmnvv7m 33 8 encephalopathies encephalopathy NNS cord-276616-odmnvv7m 33 9 that that WDT cord-276616-odmnvv7m 33 10 occurred occur VBD cord-276616-odmnvv7m 33 11 around around IN cord-276616-odmnvv7m 33 12 the the DT cord-276616-odmnvv7m 33 13 same same JJ cord-276616-odmnvv7m 33 14 time time NN cord-276616-odmnvv7m 33 15 in in IN cord-276616-odmnvv7m 33 16 other other JJ cord-276616-odmnvv7m 33 17 bovids bovid NNS cord-276616-odmnvv7m 33 18 , , , cord-276616-odmnvv7m 33 19 kept keep VBN cord-276616-odmnvv7m 33 20 in in IN cord-276616-odmnvv7m 33 21 zoological zoological JJ cord-276616-odmnvv7m 33 22 and and CC cord-276616-odmnvv7m 33 23 wildlife wildlife NN cord-276616-odmnvv7m 33 24 park park NN cord-276616-odmnvv7m 33 25 collections collection NNS cord-276616-odmnvv7m 33 26 in in IN cord-276616-odmnvv7m 33 27 Britain Britain NNP cord-276616-odmnvv7m 33 28 Cunningham Cunningham NNP cord-276616-odmnvv7m 33 29 et et NNP cord-276616-odmnvv7m 33 30 aL aL NNP cord-276616-odmnvv7m 33 31 , , , cord-276616-odmnvv7m 33 32 1993 1993 CD cord-276616-odmnvv7m 33 33 ) ) -RRB- cord-276616-odmnvv7m 33 34 . . . cord-276616-odmnvv7m 34 1 These these DT cord-276616-odmnvv7m 34 2 cases case NNS cord-276616-odmnvv7m 34 3 could could MD cord-276616-odmnvv7m 34 4 have have VB cord-276616-odmnvv7m 34 5 developed develop VBN cord-276616-odmnvv7m 34 6 through through IN cord-276616-odmnvv7m 34 7 the the DT cord-276616-odmnvv7m 34 8 animals animal NNS cord-276616-odmnvv7m 34 9 being be VBG cord-276616-odmnvv7m 34 10 fed feed VBN cord-276616-odmnvv7m 34 11 similar similar JJ cord-276616-odmnvv7m 34 12 rations ration NNS cord-276616-odmnvv7m 34 13 to to IN cord-276616-odmnvv7m 34 14 the the DT cord-276616-odmnvv7m 34 15 cattle cattle NNS cord-276616-odmnvv7m 34 16 population population NN cord-276616-odmnvv7m 34 17 . . . cord-276616-odmnvv7m 35 1 Spongiform spongiform JJ cord-276616-odmnvv7m 35 2 encephalopathy encephalopathy NN cord-276616-odmnvv7m 35 3 has have VBZ cord-276616-odmnvv7m 35 4 also also RB cord-276616-odmnvv7m 35 5 been be VBN cord-276616-odmnvv7m 35 6 found find VBN cord-276616-odmnvv7m 35 7 in in IN cord-276616-odmnvv7m 35 8 mule mule JJ cord-276616-odmnvv7m 35 9 deer deer NN cord-276616-odmnvv7m 35 10 and and CC cord-276616-odmnvv7m 35 11 captive captive JJ cord-276616-odmnvv7m 35 12 elk elk NN cord-276616-odmnvv7m 35 13 in in IN cord-276616-odmnvv7m 35 14 North North NNP cord-276616-odmnvv7m 35 15 America America NNP cord-276616-odmnvv7m 35 16 Young Young NNP cord-276616-odmnvv7m 35 17 , , , cord-276616-odmnvv7m 35 18 1980 1980 CD cord-276616-odmnvv7m 35 19 , , , cord-276616-odmnvv7m 35 20 1982 1982 CD cord-276616-odmnvv7m 35 21 ; ; : cord-276616-odmnvv7m 35 22 Wells Wells NNP cord-276616-odmnvv7m 35 23 and and CC cord-276616-odmnvv7m 35 24 McGill McGill NNP cord-276616-odmnvv7m 35 25 , , , cord-276616-odmnvv7m 35 26 1990 1990 CD cord-276616-odmnvv7m 35 27 ) ) -RRB- cord-276616-odmnvv7m 35 28 , , , cord-276616-odmnvv7m 35 29 evidence evidence NN cord-276616-odmnvv7m 35 30 that that IN cord-276616-odmnvv7m 35 31 agents agent NNS cord-276616-odmnvv7m 35 32 causing cause VBG cord-276616-odmnvv7m 35 33 encephalopathy encephalopathy NN cord-276616-odmnvv7m 35 34 are be VBP cord-276616-odmnvv7m 35 35 present present JJ cord-276616-odmnvv7m 35 36 in in IN cord-276616-odmnvv7m 35 37 wild wild JJ cord-276616-odmnvv7m 35 38 ruminants ruminant NNS cord-276616-odmnvv7m 35 39 in in IN cord-276616-odmnvv7m 35 40 that that DT cord-276616-odmnvv7m 35 41 continent continent NN cord-276616-odmnvv7m 35 42 . . . cord-276616-odmnvv7m 36 1 • • NNP cord-276616-odmnvv7m 37 1 Spongiform spongiform JJ cord-276616-odmnvv7m 37 2 encephalopathy encephalopathy NN cord-276616-odmnvv7m 37 3 has have VBZ cord-276616-odmnvv7m 37 4 recently recently RB cord-276616-odmnvv7m 37 5 been be VBN cord-276616-odmnvv7m 37 6 demonstrated demonstrate VBN cord-276616-odmnvv7m 37 7 in in IN cord-276616-odmnvv7m 37 8 domesticated domesticated JJ cord-276616-odmnvv7m 37 9 and and CC cord-276616-odmnvv7m 37 10 wild wild JJ cord-276616-odmnvv7m 37 11 felids felid NNS cord-276616-odmnvv7m 37 12 ( ( -LRB- cord-276616-odmnvv7m 37 13 Wells Wells NNP cord-276616-odmnvv7m 37 14 and and CC cord-276616-odmnvv7m 37 15 McGill McGill NNP cord-276616-odmnvv7m 37 16 , , , cord-276616-odmnvv7m 37 17 1990 1990 CD cord-276616-odmnvv7m 37 18 ; ; : cord-276616-odmnvv7m 37 19 Willoughby Willoughby NNP cord-276616-odmnvv7m 37 20 et et NNP cord-276616-odmnvv7m 37 21 aL aL NNP cord-276616-odmnvv7m 37 22 , , , cord-276616-odmnvv7m 37 23 1992 1992 CD cord-276616-odmnvv7m 37 24 ) ) -RRB- cord-276616-odmnvv7m 37 25 . . . cord-276616-odmnvv7m 38 1 * * NFP cord-276616-odmnvv7m 38 2 Please please UH cord-276616-odmnvv7m 38 3 see see VB cord-276616-odmnvv7m 38 4 Notes Notes NNP cord-276616-odmnvv7m 38 5 section section NN cord-276616-odmnvv7m 38 6 at at IN cord-276616-odmnvv7m 38 7 end end NN cord-276616-odmnvv7m 38 8 of of IN cord-276616-odmnvv7m 38 9 text text NN cord-276616-odmnvv7m 38 10 . . . cord-276616-odmnvv7m 39 1 Transmissible transmissible JJ cord-276616-odmnvv7m 39 2 mink mink NN cord-276616-odmnvv7m 39 3 encephalopathy encephalopathy NN cord-276616-odmnvv7m 39 4 ( ( -LRB- cord-276616-odmnvv7m 39 5 TME TME NNP cord-276616-odmnvv7m 39 6 ) ) -RRB- cord-276616-odmnvv7m 39 7 ( ( -LRB- cord-276616-odmnvv7m 39 8 Marsh Marsh NNP cord-276616-odmnvv7m 39 9 and and CC cord-276616-odmnvv7m 39 10 Hanson Hanson NNP cord-276616-odmnvv7m 39 11 , , , cord-276616-odmnvv7m 39 12 1969 1969 CD cord-276616-odmnvv7m 39 13 ; ; : cord-276616-odmnvv7m 39 14 Marsh Marsh NNP cord-276616-odmnvv7m 39 15 , , , cord-276616-odmnvv7m 39 16 1976 1976 CD cord-276616-odmnvv7m 39 17 ) ) -RRB- cord-276616-odmnvv7m 39 18 , , , cord-276616-odmnvv7m 39 19 which which WDT cord-276616-odmnvv7m 39 20 is be VBZ cord-276616-odmnvv7m 39 21 rarely rarely RB cord-276616-odmnvv7m 39 22 observed observe VBN cord-276616-odmnvv7m 39 23 in in IN cord-276616-odmnvv7m 39 24 ranch ranch NN cord-276616-odmnvv7m 39 25 - - HYPH cord-276616-odmnvv7m 39 26 raised raise VBN cord-276616-odmnvv7m 39 27 animals animal NNS cord-276616-odmnvv7m 39 28 , , , cord-276616-odmnvv7m 39 29 is be VBZ cord-276616-odmnvv7m 39 30 caused cause VBN cord-276616-odmnvv7m 39 31 by by IN cord-276616-odmnvv7m 39 32 an an DT cord-276616-odmnvv7m 39 33 agent agent NN cord-276616-odmnvv7m 39 34 with with IN cord-276616-odmnvv7m 39 35 the the DT cord-276616-odmnvv7m 39 36 same same JJ cord-276616-odmnvv7m 39 37 physicochemical physicochemical JJ cord-276616-odmnvv7m 39 38 properties property NNS cord-276616-odmnvv7m 39 39 as as IN cord-276616-odmnvv7m 39 40 the the DT cord-276616-odmnvv7m 39 41 scrapie scrapie NN cord-276616-odmnvv7m 39 42 agent agent NN cord-276616-odmnvv7m 39 43 . . . cord-276616-odmnvv7m 40 1 In in IN cord-276616-odmnvv7m 40 2 the the DT cord-276616-odmnvv7m 40 3 first first JJ cord-276616-odmnvv7m 40 4 outbreaks outbreak NNS cord-276616-odmnvv7m 40 5 of of IN cord-276616-odmnvv7m 40 6 TME TME NNP cord-276616-odmnvv7m 40 7 , , , cord-276616-odmnvv7m 40 8 it -PRON- PRP cord-276616-odmnvv7m 40 9 could could MD cord-276616-odmnvv7m 40 10 not not RB cord-276616-odmnvv7m 40 11 be be VB cord-276616-odmnvv7m 40 12 excluded exclude VBN cord-276616-odmnvv7m 40 13 that that IN cord-276616-odmnvv7m 40 14 the the DT cord-276616-odmnvv7m 40 15 occurrence occurrence NN cord-276616-odmnvv7m 40 16 of of IN cord-276616-odmnvv7m 40 17 the the DT cord-276616-odmnvv7m 40 18 disease disease NN cord-276616-odmnvv7m 40 19 had have VBD cord-276616-odmnvv7m 40 20 followed follow VBN cord-276616-odmnvv7m 40 21 feeding feeding NN cord-276616-odmnvv7m 40 22 of of IN cord-276616-odmnvv7m 40 23 meat meat NN cord-276616-odmnvv7m 40 24 and and CC cord-276616-odmnvv7m 40 25 offal offal NN cord-276616-odmnvv7m 40 26 from from IN cord-276616-odmnvv7m 40 27 sheep sheep NN cord-276616-odmnvv7m 40 28 , , , cord-276616-odmnvv7m 40 29 but but CC cord-276616-odmnvv7m 40 30 the the DT cord-276616-odmnvv7m 40 31 feeding feeding NN cord-276616-odmnvv7m 40 32 of of IN cord-276616-odmnvv7m 40 33 sheep sheep NN cord-276616-odmnvv7m 40 34 meat meat NN cord-276616-odmnvv7m 40 35 was be VBD cord-276616-odmnvv7m 40 36 not not RB cord-276616-odmnvv7m 40 37 involved involve VBN cord-276616-odmnvv7m 40 38 in in IN cord-276616-odmnvv7m 40 39 a a DT cord-276616-odmnvv7m 40 40 more more RBR cord-276616-odmnvv7m 40 41 recent recent JJ cord-276616-odmnvv7m 40 42 and and CC cord-276616-odmnvv7m 40 43 major major JJ cord-276616-odmnvv7m 40 44 outbreak outbreak NN cord-276616-odmnvv7m 40 45 of of IN cord-276616-odmnvv7m 40 46 TME TME NNP cord-276616-odmnvv7m 40 47 on on IN cord-276616-odmnvv7m 40 48 a a DT cord-276616-odmnvv7m 40 49 ranch ranch NN cord-276616-odmnvv7m 40 50 in in IN cord-276616-odmnvv7m 40 51 the the DT cord-276616-odmnvv7m 40 52 United United NNP cord-276616-odmnvv7m 40 53 States States NNP cord-276616-odmnvv7m 41 1 ( ( -LRB- cord-276616-odmnvv7m 41 2 Marsh Marsh NNP cord-276616-odmnvv7m 41 3 et et NNP cord-276616-odmnvv7m 41 4 al al NNP cord-276616-odmnvv7m 41 5 . . NNP cord-276616-odmnvv7m 41 6 , , , cord-276616-odmnvv7m 41 7 1991 1991 CD cord-276616-odmnvv7m 41 8 ) ) -RRB- cord-276616-odmnvv7m 41 9 . . . cord-276616-odmnvv7m 42 1 Three three CD cord-276616-odmnvv7m 42 2 diseases disease NNS cord-276616-odmnvv7m 42 3 are be VBP cord-276616-odmnvv7m 42 4 associated associate VBN cord-276616-odmnvv7m 42 5 with with IN cord-276616-odmnvv7m 42 6 spongiform spongiform JJ cord-276616-odmnvv7m 42 7 encephalopathy encephalopathy NN cord-276616-odmnvv7m 42 8 in in IN cord-276616-odmnvv7m 42 9 man man NN cord-276616-odmnvv7m 42 10 : : : cord-276616-odmnvv7m 42 11 Kuru Kuru NNP cord-276616-odmnvv7m 42 12 , , , cord-276616-odmnvv7m 42 13 Creutzfeldt Creutzfeldt NNP cord-276616-odmnvv7m 42 14 - - HYPH cord-276616-odmnvv7m 42 15 Jakob Jakob NNP cord-276616-odmnvv7m 42 16 disease disease NN cord-276616-odmnvv7m 42 17 ( ( -LRB- cord-276616-odmnvv7m 42 18 CJD CJD NNP cord-276616-odmnvv7m 42 19 ) ) -RRB- cord-276616-odmnvv7m 42 20 and and CC cord-276616-odmnvv7m 42 21 Gerstmann Gerstmann NNP cord-276616-odmnvv7m 42 22 - - HYPH cord-276616-odmnvv7m 42 23 Straiissler Straiissler NNP cord-276616-odmnvv7m 42 24 - - HYPH cord-276616-odmnvv7m 42 25 Scheinker Scheinker NNP cord-276616-odmnvv7m 42 26 disease disease NN cord-276616-odmnvv7m 42 27 ( ( -LRB- cord-276616-odmnvv7m 42 28 GSSD GSSD NNP cord-276616-odmnvv7m 42 29 ) ) -RRB- cord-276616-odmnvv7m 42 30 . . . cord-276616-odmnvv7m 43 1 Kuru Kuru NNP cord-276616-odmnvv7m 43 2 , , , cord-276616-odmnvv7m 43 3 which which WDT cord-276616-odmnvv7m 43 4 is be VBZ cord-276616-odmnvv7m 43 5 very very RB cord-276616-odmnvv7m 43 6 similar similar JJ cord-276616-odmnvv7m 43 7 to to IN cord-276616-odmnvv7m 43 8 scrapie scrapie NN cord-276616-odmnvv7m 43 9 , , , cord-276616-odmnvv7m 43 10 is be VBZ cord-276616-odmnvv7m 43 11 befieved befieve VBN cord-276616-odmnvv7m 43 12 to to TO cord-276616-odmnvv7m 43 13 be be VB cord-276616-odmnvv7m 43 14 associated associate VBN cord-276616-odmnvv7m 43 15 with with IN cord-276616-odmnvv7m 43 16 funeral funeral NN cord-276616-odmnvv7m 43 17 practices practice NNS cord-276616-odmnvv7m 43 18 involving involve VBG cord-276616-odmnvv7m 43 19 ritualistic ritualistic JJ cord-276616-odmnvv7m 43 20 cannibalism cannibalism NN cord-276616-odmnvv7m 43 21 ( ( -LRB- cord-276616-odmnvv7m 43 22 Gajdusek Gajdusek NNP cord-276616-odmnvv7m 43 23 , , , cord-276616-odmnvv7m 43 24 1977 1977 CD cord-276616-odmnvv7m 43 25 ) ) -RRB- cord-276616-odmnvv7m 43 26 . . . cord-276616-odmnvv7m 44 1 A a DT cord-276616-odmnvv7m 44 2 very very RB cord-276616-odmnvv7m 44 3 full full JJ cord-276616-odmnvv7m 44 4 account account NN cord-276616-odmnvv7m 44 5 of of IN cord-276616-odmnvv7m 44 6 this this DT cord-276616-odmnvv7m 44 7 and and CC cord-276616-odmnvv7m 44 8 other other JJ cord-276616-odmnvv7m 44 9 human human JJ cord-276616-odmnvv7m 44 10 spongiform spongiform NN cord-276616-odmnvv7m 44 11 encephalopathies encephalopathy NNS cord-276616-odmnvv7m 44 12 and and CC cord-276616-odmnvv7m 44 13 follow follow NN cord-276616-odmnvv7m 44 14 - - HYPH cord-276616-odmnvv7m 44 15 up up RP cord-276616-odmnvv7m 44 16 experimental experimental JJ cord-276616-odmnvv7m 44 17 work work NN cord-276616-odmnvv7m 44 18 is be VBZ cord-276616-odmnvv7m 44 19 given give VBN cord-276616-odmnvv7m 44 20 by by IN cord-276616-odmnvv7m 44 21 Brown Brown NNP cord-276616-odmnvv7m 44 22 and and CC cord-276616-odmnvv7m 44 23 Gajdusek Gajdusek NNP cord-276616-odmnvv7m 44 24 ( ( -LRB- cord-276616-odmnvv7m 44 25 1991 1991 CD cord-276616-odmnvv7m 44 26 ) ) -RRB- cord-276616-odmnvv7m 44 27 . . . cord-276616-odmnvv7m 45 1 CJD CJD NNP cord-276616-odmnvv7m 45 2 usually usually RB cord-276616-odmnvv7m 45 3 occurs occur VBZ cord-276616-odmnvv7m 45 4 sporadically sporadically RB cord-276616-odmnvv7m 45 5 at at IN cord-276616-odmnvv7m 45 6 a a DT cord-276616-odmnvv7m 45 7 very very RB cord-276616-odmnvv7m 45 8 low low JJ cord-276616-odmnvv7m 45 9 incidence incidence NN cord-276616-odmnvv7m 45 10 but but CC cord-276616-odmnvv7m 45 11 Deslys Deslys NNP cord-276616-odmnvv7m 45 12 and and CC cord-276616-odmnvv7m 45 13 colleagues colleague NNS cord-276616-odmnvv7m 45 14 ( ( -LRB- cord-276616-odmnvv7m 45 15 1994 1994 CD cord-276616-odmnvv7m 45 16 ) ) -RRB- cord-276616-odmnvv7m 45 17 refer refer VBP cord-276616-odmnvv7m 45 18 to to IN cord-276616-odmnvv7m 45 19 a a DT cord-276616-odmnvv7m 45 20 group group NN cord-276616-odmnvv7m 45 21 of of IN cord-276616-odmnvv7m 45 22 25 25 CD cord-276616-odmnvv7m 45 23 cases case NNS cord-276616-odmnvv7m 45 24 of of IN cord-276616-odmnvv7m 45 25 CJD CJD NNP cord-276616-odmnvv7m 45 26 that that WDT cord-276616-odmnvv7m 45 27 occurred occur VBD cord-276616-odmnvv7m 45 28 in in IN cord-276616-odmnvv7m 45 29 France France NNP cord-276616-odmnvv7m 45 30 among among IN cord-276616-odmnvv7m 45 31 children child NNS cord-276616-odmnvv7m 45 32 treated treat VBN cord-276616-odmnvv7m 45 33 between between IN cord-276616-odmnvv7m 45 34 January January NNP cord-276616-odmnvv7m 45 35 1984 1984 CD cord-276616-odmnvv7m 45 36 and and CC cord-276616-odmnvv7m 45 37 June June NNP cord-276616-odmnvv7m 45 38 1985 1985 CD cord-276616-odmnvv7m 45 39 with with IN cord-276616-odmnvv7m 45 40 human human JJ cord-276616-odmnvv7m 45 41 growth growth NN cord-276616-odmnvv7m 45 42 hormone hormone NN cord-276616-odmnvv7m 45 43 ( ( -LRB- cord-276616-odmnvv7m 45 44 hGH hGH NNP cord-276616-odmnvv7m 45 45 ) ) -RRB- cord-276616-odmnvv7m 45 46 . . . cord-276616-odmnvv7m 46 1 The the DT cord-276616-odmnvv7m 46 2 hormone hormone NN cord-276616-odmnvv7m 46 3 had have VBD cord-276616-odmnvv7m 46 4 been be VBN cord-276616-odmnvv7m 46 5 extracted extract VBN cord-276616-odmnvv7m 46 6 from from IN cord-276616-odmnvv7m 46 7 large large JJ cord-276616-odmnvv7m 46 8 numbers number NNS cord-276616-odmnvv7m 46 9 of of IN cord-276616-odmnvv7m 46 10 cadaveric cadaveric JJ cord-276616-odmnvv7m 46 11 hypophyses hypophysis NNS cord-276616-odmnvv7m 46 12 . . . cord-276616-odmnvv7m 47 1 The the DT cord-276616-odmnvv7m 47 2 cases case NNS cord-276616-odmnvv7m 47 3 were be VBD cord-276616-odmnvv7m 47 4 confined confine VBN cord-276616-odmnvv7m 47 5 to to IN cord-276616-odmnvv7m 47 6 individuals individual NNS cord-276616-odmnvv7m 47 7 with with IN cord-276616-odmnvv7m 47 8 the the DT cord-276616-odmnvv7m 47 9 same same JJ cord-276616-odmnvv7m 47 10 genetic genetic JJ cord-276616-odmnvv7m 47 11 status status NN cord-276616-odmnvv7m 47 12 as as IN cord-276616-odmnvv7m 47 13 sporadic sporadic JJ cord-276616-odmnvv7m 47 14 cases case NNS cord-276616-odmnvv7m 47 15 of of IN cord-276616-odmnvv7m 47 16 CJD CJD NNP cord-276616-odmnvv7m 47 17 , , , cord-276616-odmnvv7m 47 18 who who WP cord-276616-odmnvv7m 47 19 were be VBD cord-276616-odmnvv7m 47 20 homozygous homozygous JJ cord-276616-odmnvv7m 47 21 at at IN cord-276616-odmnvv7m 47 22 codon codon NN cord-276616-odmnvv7m 47 23 129 129 CD cord-276616-odmnvv7m 47 24 of of IN cord-276616-odmnvv7m 47 25 the the DT cord-276616-odmnvv7m 47 26 PrP prp NN cord-276616-odmnvv7m 47 27 gene gene NN cord-276616-odmnvv7m 47 28 . . . cord-276616-odmnvv7m 48 1 GSSD GSSD NNP cord-276616-odmnvv7m 48 2 shows show VBZ cord-276616-odmnvv7m 48 3 a a DT cord-276616-odmnvv7m 48 4 clinical clinical JJ cord-276616-odmnvv7m 48 5 overlap overlap NN cord-276616-odmnvv7m 48 6 between between IN cord-276616-odmnvv7m 48 7 Kuru Kuru NNP cord-276616-odmnvv7m 48 8 and and CC cord-276616-odmnvv7m 48 9 CJD CJD NNP cord-276616-odmnvv7m 48 10 but but CC cord-276616-odmnvv7m 48 11 is be VBZ cord-276616-odmnvv7m 48 12 familial familial JJ cord-276616-odmnvv7m 48 13 and and CC cord-276616-odmnvv7m 48 14 related relate VBN cord-276616-odmnvv7m 48 15 to to IN cord-276616-odmnvv7m 48 16 a a DT cord-276616-odmnvv7m 48 17 point point NN cord-276616-odmnvv7m 48 18 mutation mutation NN cord-276616-odmnvv7m 48 19 on on IN cord-276616-odmnvv7m 48 20 chromosome chromosome NN cord-276616-odmnvv7m 48 21 20 20 CD cord-276616-odmnvv7m 48 22 , , , cord-276616-odmnvv7m 48 23 which which WDT cord-276616-odmnvv7m 48 24 encodes encode VBZ cord-276616-odmnvv7m 48 25 an an DT cord-276616-odmnvv7m 48 26 amyloidogenic amyloidogenic NNP cord-276616-odmnvv7m 48 27 protein protein NN cord-276616-odmnvv7m 48 28 PrP prp NN cord-276616-odmnvv7m 48 29 ( ( -LRB- cord-276616-odmnvv7m 48 30 Brown Brown NNP cord-276616-odmnvv7m 48 31 , , , cord-276616-odmnvv7m 48 32 1990 1990 CD cord-276616-odmnvv7m 48 33 ) ) -RRB- cord-276616-odmnvv7m 48 34 . . . cord-276616-odmnvv7m 49 1 As as IN cord-276616-odmnvv7m 49 2 in in IN cord-276616-odmnvv7m 49 3 scrapie scrapie NN cord-276616-odmnvv7m 49 4 and and CC cord-276616-odmnvv7m 49 5 BSE BSE NNP cord-276616-odmnvv7m 49 6 , , , cord-276616-odmnvv7m 49 7 the the DT cord-276616-odmnvv7m 49 8 causative causative JJ cord-276616-odmnvv7m 49 9 agent agent NN cord-276616-odmnvv7m 49 10 of of IN cord-276616-odmnvv7m 49 11 CJD CJD NNP cord-276616-odmnvv7m 49 12 can can MD cord-276616-odmnvv7m 49 13 be be VB cord-276616-odmnvv7m 49 14 transmitted transmit VBN cord-276616-odmnvv7m 49 15 to to IN cord-276616-odmnvv7m 49 16 experimental experimental JJ cord-276616-odmnvv7m 49 17 animals animal NNS cord-276616-odmnvv7m 50 1 ( ( -LRB- cord-276616-odmnvv7m 50 2 Gibbs Gibbs NNP cord-276616-odmnvv7m 50 3 et et NNP cord-276616-odmnvv7m 50 4 aL aL NNP cord-276616-odmnvv7m 50 5 , , , cord-276616-odmnvv7m 50 6 1979 1979 CD cord-276616-odmnvv7m 50 7 ; ; : cord-276616-odmnvv7m 51 1 Manuelidis Manuelidis NNP cord-276616-odmnvv7m 51 2 and and CC cord-276616-odmnvv7m 51 3 Manuelidis Manuelidis NNP cord-276616-odmnvv7m 51 4 , , , cord-276616-odmnvv7m 51 5 1979 1979 CD cord-276616-odmnvv7m 51 6 ; ; : cord-276616-odmnvv7m 51 7 Tateishi Tateishi NNP cord-276616-odmnvv7m 51 8 et et NNP cord-276616-odmnvv7m 51 9 aL aL NNP cord-276616-odmnvv7m 51 10 , , , cord-276616-odmnvv7m 51 11 1979 1979 CD cord-276616-odmnvv7m 51 12 ) ) -RRB- cord-276616-odmnvv7m 51 13 . . . cord-276616-odmnvv7m 52 1 Thus thus RB cord-276616-odmnvv7m 52 2 spongiform spongiform JJ cord-276616-odmnvv7m 52 3 encephalopathies encephalopathy NNS cord-276616-odmnvv7m 52 4 have have VBP cord-276616-odmnvv7m 52 5 been be VBN cord-276616-odmnvv7m 52 6 described describe VBN cord-276616-odmnvv7m 52 7 in in IN cord-276616-odmnvv7m 52 8 several several JJ cord-276616-odmnvv7m 52 9 species specie NNS cord-276616-odmnvv7m 52 10 , , , cord-276616-odmnvv7m 52 11 and and CC cord-276616-odmnvv7m 52 12 in in IN cord-276616-odmnvv7m 52 13 most most JJS cord-276616-odmnvv7m 52 14 of of IN cord-276616-odmnvv7m 52 15 them -PRON- PRP cord-276616-odmnvv7m 52 16 the the DT cord-276616-odmnvv7m 52 17 disease disease NN cord-276616-odmnvv7m 52 18 has have VBZ cord-276616-odmnvv7m 52 19 been be VBN cord-276616-odmnvv7m 52 20 shown show VBN cord-276616-odmnvv7m 52 21 to to TO cord-276616-odmnvv7m 52 22 be be VB cord-276616-odmnvv7m 52 23 transmissible transmissible JJ cord-276616-odmnvv7m 52 24 to to IN cord-276616-odmnvv7m 52 25 animals animal NNS cord-276616-odmnvv7m 52 26 of of IN cord-276616-odmnvv7m 52 27 the the DT cord-276616-odmnvv7m 52 28 same same JJ cord-276616-odmnvv7m 52 29 species specie NNS cord-276616-odmnvv7m 52 30 , , , cord-276616-odmnvv7m 52 31 where where WRB cord-276616-odmnvv7m 52 32 this this DT cord-276616-odmnvv7m 52 33 is be VBZ cord-276616-odmnvv7m 52 34 ethically ethically RB cord-276616-odmnvv7m 52 35 possible possible JJ cord-276616-odmnvv7m 52 36 , , , cord-276616-odmnvv7m 52 37 and and CC cord-276616-odmnvv7m 52 38 to to IN cord-276616-odmnvv7m 52 39 certain certain JJ cord-276616-odmnvv7m 52 40 laboratory laboratory NN cord-276616-odmnvv7m 52 41 animals animal NNS cord-276616-odmnvv7m 52 42 . . . cord-276616-odmnvv7m 53 1 The the DT cord-276616-odmnvv7m 53 2 purpose purpose NN cord-276616-odmnvv7m 53 3 of of IN cord-276616-odmnvv7m 53 4 this this DT cord-276616-odmnvv7m 53 5 paper paper NN cord-276616-odmnvv7m 53 6 is be VBZ cord-276616-odmnvv7m 53 7 to to TO cord-276616-odmnvv7m 53 8 give give VB cord-276616-odmnvv7m 53 9 a a DT cord-276616-odmnvv7m 53 10 condensed condense VBN cord-276616-odmnvv7m 53 11 overview overview NN cord-276616-odmnvv7m 53 12 of of IN cord-276616-odmnvv7m 53 13 the the DT cord-276616-odmnvv7m 53 14 aetiology aetiology NN cord-276616-odmnvv7m 53 15 , , , cord-276616-odmnvv7m 53 16 pathology pathology NN cord-276616-odmnvv7m 53 17 and and CC cord-276616-odmnvv7m 53 18 familial familial JJ cord-276616-odmnvv7m 53 19 nature nature NN cord-276616-odmnvv7m 53 20 of of IN cord-276616-odmnvv7m 53 21 some some DT cord-276616-odmnvv7m 53 22 of of IN cord-276616-odmnvv7m 53 23 the the DT cord-276616-odmnvv7m 53 24 spongiform spongiform JJ cord-276616-odmnvv7m 53 25 encephalopathies encephalopathy NNS cord-276616-odmnvv7m 53 26 as as RB cord-276616-odmnvv7m 53 27 well well RB cord-276616-odmnvv7m 53 28 as as IN cord-276616-odmnvv7m 53 29 aspects aspect NNS cord-276616-odmnvv7m 53 30 of of IN cord-276616-odmnvv7m 53 31 diagnosis diagnosis NN cord-276616-odmnvv7m 53 32 and and CC cord-276616-odmnvv7m 53 33 serology serology NN cord-276616-odmnvv7m 53 34 ; ; : cord-276616-odmnvv7m 53 35 it -PRON- PRP cord-276616-odmnvv7m 53 36 will will MD cord-276616-odmnvv7m 53 37 particularly particularly RB cord-276616-odmnvv7m 53 38 address address VB cord-276616-odmnvv7m 53 39 the the DT cord-276616-odmnvv7m 53 40 possibility possibility NN cord-276616-odmnvv7m 53 41 of of IN cord-276616-odmnvv7m 53 42 a a DT cord-276616-odmnvv7m 53 43 viral viral JJ cord-276616-odmnvv7m 53 44 aetiology aetiology NN cord-276616-odmnvv7m 53 45 for for IN cord-276616-odmnvv7m 53 46 these these DT cord-276616-odmnvv7m 53 47 diseases disease NNS cord-276616-odmnvv7m 53 48 . . . cord-276616-odmnvv7m 54 1 There there EX cord-276616-odmnvv7m 54 2 are be VBP cord-276616-odmnvv7m 54 3 many many JJ cord-276616-odmnvv7m 54 4 difficulties difficulty NNS cord-276616-odmnvv7m 54 5 in in IN cord-276616-odmnvv7m 54 6 studying study VBG cord-276616-odmnvv7m 54 7 either either CC cord-276616-odmnvv7m 54 8 the the DT cord-276616-odmnvv7m 54 9 natural natural JJ cord-276616-odmnvv7m 54 10 or or CC cord-276616-odmnvv7m 54 11 experimentally experimentally RB cord-276616-odmnvv7m 54 12 induced induce VBN cord-276616-odmnvv7m 54 13 diseases disease NNS cord-276616-odmnvv7m 54 14 : : : cord-276616-odmnvv7m 54 15 the the DT cord-276616-odmnvv7m 54 16 animals animal NNS cord-276616-odmnvv7m 54 17 involved involve VBN cord-276616-odmnvv7m 54 18 , , , cord-276616-odmnvv7m 54 19 the the DT cord-276616-odmnvv7m 54 20 incubation incubation NN cord-276616-odmnvv7m 54 21 period period NN cord-276616-odmnvv7m 54 22 required require VBN cord-276616-odmnvv7m 54 23 for for IN cord-276616-odmnvv7m 54 24 the the DT cord-276616-odmnvv7m 54 25 emergence emergence NN cord-276616-odmnvv7m 54 26 of of IN cord-276616-odmnvv7m 54 27 the the DT cord-276616-odmnvv7m 54 28 disease disease NN cord-276616-odmnvv7m 54 29 , , , cord-276616-odmnvv7m 54 30 the the DT cord-276616-odmnvv7m 54 31 innate innate JJ cord-276616-odmnvv7m 54 32 resistance resistance NN cord-276616-odmnvv7m 54 33 of of IN cord-276616-odmnvv7m 54 34 a a DT cord-276616-odmnvv7m 54 35 proportion proportion NN cord-276616-odmnvv7m 54 36 of of IN cord-276616-odmnvv7m 54 37 the the DT cord-276616-odmnvv7m 54 38 population population NN cord-276616-odmnvv7m 54 39 seen see VBN cord-276616-odmnvv7m 54 40 as as IN cord-276616-odmnvv7m 54 41 an an DT cord-276616-odmnvv7m 54 42 expression expression NN cord-276616-odmnvv7m 54 43 of of IN cord-276616-odmnvv7m 54 44 genetic genetic JJ cord-276616-odmnvv7m 54 45 influences influence NNS cord-276616-odmnvv7m 54 46 , , , cord-276616-odmnvv7m 54 47 the the DT cord-276616-odmnvv7m 54 48 differing differ VBG cord-276616-odmnvv7m 54 49 behaviour behaviour NN cord-276616-odmnvv7m 54 50 of of IN cord-276616-odmnvv7m 54 51 strains strain NNS cord-276616-odmnvv7m 54 52 of of IN cord-276616-odmnvv7m 54 53 agents agent NNS cord-276616-odmnvv7m 54 54 isolated isolate VBN cord-276616-odmnvv7m 54 55 from from IN cord-276616-odmnvv7m 54 56 a a DT cord-276616-odmnvv7m 54 57 given give VBN cord-276616-odmnvv7m 54 58 species species NN cord-276616-odmnvv7m 54 59 , , , cord-276616-odmnvv7m 54 60 the the DT cord-276616-odmnvv7m 54 61 symptomatology symptomatology NN cord-276616-odmnvv7m 54 62 , , , cord-276616-odmnvv7m 54 63 the the DT cord-276616-odmnvv7m 54 64 pathology pathology NN cord-276616-odmnvv7m 54 65 , , , cord-276616-odmnvv7m 54 66 the the DT cord-276616-odmnvv7m 54 67 uncertain uncertain JJ cord-276616-odmnvv7m 54 68 nature nature NN cord-276616-odmnvv7m 54 69 of of IN cord-276616-odmnvv7m 54 70 the the DT cord-276616-odmnvv7m 54 71 agent agent NN cord-276616-odmnvv7m 54 72 and and CC cord-276616-odmnvv7m 54 73 its -PRON- PRP$ cord-276616-odmnvv7m 54 74 means mean NNS cord-276616-odmnvv7m 54 75 of of IN cord-276616-odmnvv7m 54 76 transmission transmission NN cord-276616-odmnvv7m 54 77 , , , cord-276616-odmnvv7m 54 78 the the DT cord-276616-odmnvv7m 54 79 perceived perceive VBN cord-276616-odmnvv7m 54 80 ' ' `` cord-276616-odmnvv7m 54 81 lack lack NN cord-276616-odmnvv7m 54 82 ' ' '' cord-276616-odmnvv7m 54 83 of of IN cord-276616-odmnvv7m 54 84 an an DT cord-276616-odmnvv7m 54 85 immunological immunological JJ cord-276616-odmnvv7m 54 86 response response NN cord-276616-odmnvv7m 54 87 or or CC cord-276616-odmnvv7m 54 88 changes change NNS cord-276616-odmnvv7m 54 89 in in IN cord-276616-odmnvv7m 54 90 the the DT cord-276616-odmnvv7m 54 91 immune immune JJ cord-276616-odmnvv7m 54 92 system system NN cord-276616-odmnvv7m 54 93 , , , cord-276616-odmnvv7m 54 94 and and CC cord-276616-odmnvv7m 54 95 the the DT cord-276616-odmnvv7m 54 96 biological biological JJ cord-276616-odmnvv7m 54 97 hazards hazard NNS cord-276616-odmnvv7m 54 98 involved involve VBN cord-276616-odmnvv7m 54 99 in in IN cord-276616-odmnvv7m 54 100 conducting conduct VBG cord-276616-odmnvv7m 54 101 experiments experiment NNS cord-276616-odmnvv7m 54 102 . . . cord-276616-odmnvv7m 55 1 None none NN cord-276616-odmnvv7m 55 2 of of IN cord-276616-odmnvv7m 55 3 the the DT cord-276616-odmnvv7m 55 4 infective infective JJ cord-276616-odmnvv7m 55 5 agents agent NNS cord-276616-odmnvv7m 55 6 that that WDT cord-276616-odmnvv7m 55 7 cause cause VBP cord-276616-odmnvv7m 55 8 the the DT cord-276616-odmnvv7m 55 9 spongiform spongiform JJ cord-276616-odmnvv7m 55 10 encephalopathies encephalopathy NNS cord-276616-odmnvv7m 55 11 can can MD cord-276616-odmnvv7m 55 12 be be VB cord-276616-odmnvv7m 55 13 demonstrated demonstrate VBN cord-276616-odmnvv7m 55 14 except except IN cord-276616-odmnvv7m 55 15 by by IN cord-276616-odmnvv7m 55 16 animal animal NN cord-276616-odmnvv7m 55 17 inoculation inoculation NN cord-276616-odmnvv7m 55 18 . . . cord-276616-odmnvv7m 56 1 Sheep Sheep NNS cord-276616-odmnvv7m 56 2 were be VBD cord-276616-odmnvv7m 56 3 the the DT cord-276616-odmnvv7m 56 4 first first JJ cord-276616-odmnvv7m 56 5 experimental experimental JJ cord-276616-odmnvv7m 56 6 animals animal NNS cord-276616-odmnvv7m 56 7 used use VBN cord-276616-odmnvv7m 56 8 for for IN cord-276616-odmnvv7m 56 9 research research NN cord-276616-odmnvv7m 56 10 on on IN cord-276616-odmnvv7m 56 11 this this DT cord-276616-odmnvv7m 56 12 group group NN cord-276616-odmnvv7m 56 13 of of IN cord-276616-odmnvv7m 56 14 diseases disease NNS cord-276616-odmnvv7m 56 15 ( ( -LRB- cord-276616-odmnvv7m 56 16 scrapie scrapie NN cord-276616-odmnvv7m 56 17 ) ) -RRB- cord-276616-odmnvv7m 56 18 and and CC cord-276616-odmnvv7m 56 19 the the DT cord-276616-odmnvv7m 56 20 intracerebral intracerebral JJ cord-276616-odmnvv7m 56 21 route route NN cord-276616-odmnvv7m 56 22 of of IN cord-276616-odmnvv7m 56 23 inoculation inoculation NN cord-276616-odmnvv7m 56 24 was be VBD cord-276616-odmnvv7m 56 25 found find VBN cord-276616-odmnvv7m 56 26 to to TO cord-276616-odmnvv7m 56 27 be be VB cord-276616-odmnvv7m 56 28 better well JJR cord-276616-odmnvv7m 56 29 than than IN cord-276616-odmnvv7m 56 30 the the DT cord-276616-odmnvv7m 56 31 subcutaneous subcutaneous JJ cord-276616-odmnvv7m 56 32 route route NN cord-276616-odmnvv7m 56 33 for for IN cord-276616-odmnvv7m 56 34 obtaining obtain VBG cord-276616-odmnvv7m 56 35 the the DT cord-276616-odmnvv7m 56 36 maximum maximum JJ cord-276616-odmnvv7m 56 37 incidence incidence NN cord-276616-odmnvv7m 56 38 of of IN cord-276616-odmnvv7m 56 39 disease disease NN cord-276616-odmnvv7m 56 40 . . . cord-276616-odmnvv7m 57 1 There there EX cord-276616-odmnvv7m 57 2 are be VBP cord-276616-odmnvv7m 57 3 ethical ethical JJ cord-276616-odmnvv7m 57 4 , , , cord-276616-odmnvv7m 57 5 logistical logistical JJ cord-276616-odmnvv7m 57 6 and and CC cord-276616-odmnvv7m 57 7 humanitarian humanitarian JJ cord-276616-odmnvv7m 57 8 considerations consideration NNS cord-276616-odmnvv7m 57 9 against against IN cord-276616-odmnvv7m 57 10 using use VBG cord-276616-odmnvv7m 57 11 large large JJ cord-276616-odmnvv7m 57 12 animals animal NNS cord-276616-odmnvv7m 57 13 for for IN cord-276616-odmnvv7m 57 14 this this DT cord-276616-odmnvv7m 57 15 type type NN cord-276616-odmnvv7m 57 16 of of IN cord-276616-odmnvv7m 57 17 study study NN cord-276616-odmnvv7m 57 18 . . . cord-276616-odmnvv7m 58 1 The the DT cord-276616-odmnvv7m 58 2 finding finding NN cord-276616-odmnvv7m 58 3 that that IN cord-276616-odmnvv7m 58 4 the the DT cord-276616-odmnvv7m 58 5 spongiform spongiform JJ cord-276616-odmnvv7m 58 6 encephalopathies encephalopathy NNS cord-276616-odmnvv7m 58 7 were be VBD cord-276616-odmnvv7m 58 8 transmissible transmissible JJ cord-276616-odmnvv7m 58 9 to to IN cord-276616-odmnvv7m 58 10 certain certain JJ cord-276616-odmnvv7m 58 11 laboratory laboratory NN cord-276616-odmnvv7m 58 12 animals animal NNS cord-276616-odmnvv7m 58 13 ( ( -LRB- cord-276616-odmnvv7m 58 14 mice mouse NNS cord-276616-odmnvv7m 58 15 , , , cord-276616-odmnvv7m 58 16 hamsters hamster NNS cord-276616-odmnvv7m 58 17 and and CC cord-276616-odmnvv7m 58 18 laboratory laboratory NN cord-276616-odmnvv7m 58 19 primates primate NNS cord-276616-odmnvv7m 58 20 ) ) -RRB- cord-276616-odmnvv7m 58 21 was be VBD cord-276616-odmnvv7m 58 22 a a DT cord-276616-odmnvv7m 58 23 critically critically RB cord-276616-odmnvv7m 58 24 important important JJ cord-276616-odmnvv7m 58 25 advance advance NN cord-276616-odmnvv7m 58 26 . . . cord-276616-odmnvv7m 59 1 It -PRON- PRP cord-276616-odmnvv7m 59 2 then then RB cord-276616-odmnvv7m 59 3 became become VBD cord-276616-odmnvv7m 59 4 possible possible JJ cord-276616-odmnvv7m 59 5 to to TO cord-276616-odmnvv7m 59 6 titrate titrate VB cord-276616-odmnvv7m 59 7 the the DT cord-276616-odmnvv7m 59 8 infectivity infectivity NN cord-276616-odmnvv7m 59 9 of of IN cord-276616-odmnvv7m 59 10 spleen spleen NN cord-276616-odmnvv7m 59 11 , , , cord-276616-odmnvv7m 59 12 brain brain NN cord-276616-odmnvv7m 59 13 and and CC cord-276616-odmnvv7m 59 14 other other JJ cord-276616-odmnvv7m 59 15 tissues tissue NNS cord-276616-odmnvv7m 59 16 in in IN cord-276616-odmnvv7m 59 17 small small JJ cord-276616-odmnvv7m 59 18 laboratory laboratory NN cord-276616-odmnvv7m 59 19 animals animal NNS cord-276616-odmnvv7m 59 20 , , , cord-276616-odmnvv7m 59 21 which which WDT cord-276616-odmnvv7m 59 22 was be VBD cord-276616-odmnvv7m 59 23 essential essential JJ cord-276616-odmnvv7m 59 24 if if IN cord-276616-odmnvv7m 59 25 any any DT cord-276616-odmnvv7m 59 26 real real JJ cord-276616-odmnvv7m 59 27 advance advance NN cord-276616-odmnvv7m 59 28 in in IN cord-276616-odmnvv7m 59 29 our -PRON- PRP$ cord-276616-odmnvv7m 59 30 understanding understanding NN cord-276616-odmnvv7m 59 31 of of IN cord-276616-odmnvv7m 59 32 the the DT cord-276616-odmnvv7m 59 33 causative causative JJ cord-276616-odmnvv7m 59 34 agents agent NNS cord-276616-odmnvv7m 59 35 was be VBD cord-276616-odmnvv7m 59 36 to to TO cord-276616-odmnvv7m 59 37 be be VB cord-276616-odmnvv7m 59 38 obtained obtain VBN cord-276616-odmnvv7m 59 39 . . . cord-276616-odmnvv7m 60 1 However however RB cord-276616-odmnvv7m 60 2 , , , cord-276616-odmnvv7m 60 3 a a DT cord-276616-odmnvv7m 60 4 problem problem NN cord-276616-odmnvv7m 60 5 with with IN cord-276616-odmnvv7m 60 6 the the DT cord-276616-odmnvv7m 60 7 use use NN cord-276616-odmnvv7m 60 8 of of IN cord-276616-odmnvv7m 60 9 laboratory laboratory NN cord-276616-odmnvv7m 60 10 animals animal NNS cord-276616-odmnvv7m 60 11 is be VBZ cord-276616-odmnvv7m 60 12 that that IN cord-276616-odmnvv7m 60 13 they -PRON- PRP cord-276616-odmnvv7m 60 14 may may MD cord-276616-odmnvv7m 60 15 carry carry VB cord-276616-odmnvv7m 60 16 other other JJ cord-276616-odmnvv7m 60 17 disease disease NN cord-276616-odmnvv7m 60 18 agents agent NNS cord-276616-odmnvv7m 60 19 in in IN cord-276616-odmnvv7m 60 20 a a DT cord-276616-odmnvv7m 60 21 latent latent JJ cord-276616-odmnvv7m 60 22 form form NN cord-276616-odmnvv7m 60 23 . . . cord-276616-odmnvv7m 61 1 The the DT cord-276616-odmnvv7m 61 2 presence presence NN cord-276616-odmnvv7m 61 3 of of IN cord-276616-odmnvv7m 61 4 such such JJ cord-276616-odmnvv7m 61 5 agents agent NNS cord-276616-odmnvv7m 61 6 might may MD cord-276616-odmnvv7m 61 7 even even RB cord-276616-odmnvv7m 61 8 determine determine VB cord-276616-odmnvv7m 61 9 whether whether IN cord-276616-odmnvv7m 61 10 or or CC cord-276616-odmnvv7m 61 11 not not RB cord-276616-odmnvv7m 61 12 scrapie scrapie NN cord-276616-odmnvv7m 61 13 appears appear VBZ cord-276616-odmnvv7m 61 14 following follow VBG cord-276616-odmnvv7m 61 15 inoculation inoculation NN cord-276616-odmnvv7m 61 16 with with IN cord-276616-odmnvv7m 61 17 infected infected JJ cord-276616-odmnvv7m 61 18 material material NN cord-276616-odmnvv7m 61 19 and and CC cord-276616-odmnvv7m 61 20 also also RB cord-276616-odmnvv7m 61 21 the the DT cord-276616-odmnvv7m 61 22 progress progress NN cord-276616-odmnvv7m 61 23 of of IN cord-276616-odmnvv7m 61 24 the the DT cord-276616-odmnvv7m 61 25 disease disease NN cord-276616-odmnvv7m 61 26 . . . cord-276616-odmnvv7m 62 1 This this DT cord-276616-odmnvv7m 62 2 possibility possibility NN cord-276616-odmnvv7m 62 3 has have VBZ cord-276616-odmnvv7m 62 4 attracted attract VBN cord-276616-odmnvv7m 62 5 attention attention NN cord-276616-odmnvv7m 62 6 , , , cord-276616-odmnvv7m 62 7 and and CC cord-276616-odmnvv7m 62 8 ' ' `` cord-276616-odmnvv7m 62 9 caesarian caesarian NN cord-276616-odmnvv7m 62 10 - - HYPH cord-276616-odmnvv7m 62 11 derived derive VBN cord-276616-odmnvv7m 62 12 , , , cord-276616-odmnvv7m 62 13 barrier barrier NN cord-276616-odmnvv7m 62 14 - - HYPH cord-276616-odmnvv7m 62 15 maintained maintain VBN cord-276616-odmnvv7m 62 16 colonies colony NNS cord-276616-odmnvv7m 62 17 have have VBP cord-276616-odmnvv7m 62 18 been be VBN cord-276616-odmnvv7m 62 19 the the DT cord-276616-odmnvv7m 62 20 rule rule NN cord-276616-odmnvv7m 62 21 for for IN cord-276616-odmnvv7m 62 22 most most JJS cord-276616-odmnvv7m 62 23 serious serious JJ cord-276616-odmnvv7m 62 24 work work NN cord-276616-odmnvv7m 62 25 in in IN cord-276616-odmnvv7m 62 26 small small JJ cord-276616-odmnvv7m 62 27 laboratory laboratory NN cord-276616-odmnvv7m 62 28 animals animal NNS cord-276616-odmnvv7m 62 29 . . . cord-276616-odmnvv7m 63 1 Neoplasia neoplasia NN cord-276616-odmnvv7m 63 2 , , , cord-276616-odmnvv7m 63 3 however however RB cord-276616-odmnvv7m 63 4 , , , cord-276616-odmnvv7m 63 5 remains remain VBZ cord-276616-odmnvv7m 63 6 a a DT cord-276616-odmnvv7m 63 7 problem problem NN cord-276616-odmnvv7m 63 8 in in IN cord-276616-odmnvv7m 63 9 some some DT cord-276616-odmnvv7m 63 10 colonies colony NNS cord-276616-odmnvv7m 63 11 of of IN cord-276616-odmnvv7m 63 12 laboratory laboratory NN cord-276616-odmnvv7m 63 13 rodents rodent NNS cord-276616-odmnvv7m 63 14 ' ' '' cord-276616-odmnvv7m 63 15 ( ( -LRB- cord-276616-odmnvv7m 63 16 R.M. R.M. NNP cord-276616-odmnvv7m 63 17 Barlow Barlow NNP cord-276616-odmnvv7m 63 18 , , , cord-276616-odmnvv7m 63 19 personal personal JJ cord-276616-odmnvv7m 63 20 communication communication NN cord-276616-odmnvv7m 63 21 , , , cord-276616-odmnvv7m 63 22 1994 1994 CD cord-276616-odmnvv7m 63 23 ) ) -RRB- cord-276616-odmnvv7m 63 24 . . . cord-276616-odmnvv7m 64 1 The the DT cord-276616-odmnvv7m 64 2 need need NN cord-276616-odmnvv7m 64 3 to to TO cord-276616-odmnvv7m 64 4 hold hold VB cord-276616-odmnvv7m 64 5 and and CC cord-276616-odmnvv7m 64 6 observe observe VB cord-276616-odmnvv7m 64 7 animals animal NNS cord-276616-odmnvv7m 64 8 for for IN cord-276616-odmnvv7m 64 9 long long JJ cord-276616-odmnvv7m 64 10 periods period NNS cord-276616-odmnvv7m 64 11 of of IN cord-276616-odmnvv7m 64 12 time time NN cord-276616-odmnvv7m 64 13 is be VBZ cord-276616-odmnvv7m 64 14 a a DT cord-276616-odmnvv7m 64 15 great great JJ cord-276616-odmnvv7m 64 16 inconvenience inconvenience NN cord-276616-odmnvv7m 64 17 in in IN cord-276616-odmnvv7m 64 18 studies study NNS cord-276616-odmnvv7m 64 19 on on IN cord-276616-odmnvv7m 64 20 natural natural JJ cord-276616-odmnvv7m 64 21 and and CC cord-276616-odmnvv7m 64 22 experimental experimental JJ cord-276616-odmnvv7m 64 23 transmission transmission NN cord-276616-odmnvv7m 64 24 of of IN cord-276616-odmnvv7m 64 25 the the DT cord-276616-odmnvv7m 64 26 spongiform spongiform JJ cord-276616-odmnvv7m 64 27 encephalopathies encephalopathy NNS cord-276616-odmnvv7m 64 28 . . . cord-276616-odmnvv7m 65 1 In in IN cord-276616-odmnvv7m 65 2 BSE BSE NNP cord-276616-odmnvv7m 65 3 , , , cord-276616-odmnvv7m 65 4 for for IN cord-276616-odmnvv7m 65 5 instance instance NN cord-276616-odmnvv7m 65 6 , , , cord-276616-odmnvv7m 65 7 some some DT cord-276616-odmnvv7m 65 8 cases case NNS cord-276616-odmnvv7m 65 9 are be VBP cord-276616-odmnvv7m 65 10 still still RB cord-276616-odmnvv7m 65 11 emerging emerge VBG cord-276616-odmnvv7m 65 12 that that WDT cord-276616-odmnvv7m 65 13 may may MD cord-276616-odmnvv7m 65 14 reflect reflect VB cord-276616-odmnvv7m 65 15 exposure exposure NN cord-276616-odmnvv7m 65 16 to to IN cord-276616-odmnvv7m 65 17 the the DT cord-276616-odmnvv7m 65 18 agent agent NN cord-276616-odmnvv7m 65 19 in in IN cord-276616-odmnvv7m 65 20 the the DT cord-276616-odmnvv7m 65 21 early early JJ cord-276616-odmnvv7m 65 22 1980s 1980s CD cord-276616-odmnvv7m 65 23 . . . cord-276616-odmnvv7m 66 1 In in IN cord-276616-odmnvv7m 66 2 ovine ovine JJ cord-276616-odmnvv7m 66 3 experiments experiment NNS cord-276616-odmnvv7m 66 4 , , , cord-276616-odmnvv7m 66 5 the the DT cord-276616-odmnvv7m 66 6 4V2-year 4v2-year CD cord-276616-odmnvv7m 66 7 period period NN cord-276616-odmnvv7m 66 8 of of IN cord-276616-odmnvv7m 66 9 observation observation NN cord-276616-odmnvv7m 66 10 noted note VBN cord-276616-odmnvv7m 66 11 in in IN cord-276616-odmnvv7m 66 12 the the DT cord-276616-odmnvv7m 66 13 early early JJ cord-276616-odmnvv7m 66 14 Scottish scottish JJ cord-276616-odmnvv7m 66 15 transmission transmission NN cord-276616-odmnvv7m 66 16 experiments experiment NNS cord-276616-odmnvv7m 66 17 was be VBD cord-276616-odmnvv7m 66 18 not not RB cord-276616-odmnvv7m 66 19 excessive excessive JJ cord-276616-odmnvv7m 66 20 , , , cord-276616-odmnvv7m 66 21 although although IN cord-276616-odmnvv7m 66 22 enough enough JJ cord-276616-odmnvv7m 66 23 data datum NNS cord-276616-odmnvv7m 66 24 can can MD cord-276616-odmnvv7m 66 25 usually usually RB cord-276616-odmnvv7m 66 26 be be VB cord-276616-odmnvv7m 66 27 collected collect VBN cord-276616-odmnvv7m 66 28 within within IN cord-276616-odmnvv7m 66 29 a a DT cord-276616-odmnvv7m 66 30 2-year 2-year CD cord-276616-odmnvv7m 66 31 period period NN cord-276616-odmnvv7m 66 32 in in IN cord-276616-odmnvv7m 66 33 sheep sheep NNS cord-276616-odmnvv7m 66 34 . . . cord-276616-odmnvv7m 67 1 In in IN cord-276616-odmnvv7m 67 2 mice mouse NNS cord-276616-odmnvv7m 67 3 , , , cord-276616-odmnvv7m 67 4 scrapie scrapie NN cord-276616-odmnvv7m 67 5 infection infection NN cord-276616-odmnvv7m 67 6 progresses progress VBZ cord-276616-odmnvv7m 67 7 more more RBR cord-276616-odmnvv7m 67 8 quickly quickly RB cord-276616-odmnvv7m 67 9 , , , cord-276616-odmnvv7m 67 10 and and CC cord-276616-odmnvv7m 67 11 if if IN cord-276616-odmnvv7m 67 12 4 4 CD cord-276616-odmnvv7m 67 13 - - HYPH cord-276616-odmnvv7m 67 14 5-week 5-week JJ cord-276616-odmnvv7m 67 15 - - HYPH cord-276616-odmnvv7m 67 16 old old JJ cord-276616-odmnvv7m 67 17 animals animal NNS cord-276616-odmnvv7m 67 18 are be VBP cord-276616-odmnvv7m 67 19 inoculated inoculate VBN cord-276616-odmnvv7m 67 20 intracerebrally intracerebrally RB cord-276616-odmnvv7m 67 21 with with IN cord-276616-odmnvv7m 67 22 large large JJ cord-276616-odmnvv7m 67 23 amounts amount NNS cord-276616-odmnvv7m 67 24 of of IN cord-276616-odmnvv7m 67 25 the the DT cord-276616-odmnvv7m 67 26 agent agent NN cord-276616-odmnvv7m 67 27 most most JJS cord-276616-odmnvv7m 67 28 of of IN cord-276616-odmnvv7m 67 29 them -PRON- PRP cord-276616-odmnvv7m 67 30 will will MD cord-276616-odmnvv7m 67 31 develop develop VB cord-276616-odmnvv7m 67 32 the the DT cord-276616-odmnvv7m 67 33 disease disease NN cord-276616-odmnvv7m 67 34 within within IN cord-276616-odmnvv7m 67 35 10 10 CD cord-276616-odmnvv7m 67 36 months month NNS cord-276616-odmnvv7m 67 37 ( ( -LRB- cord-276616-odmnvv7m 67 38 Chandler Chandler NNP cord-276616-odmnvv7m 67 39 , , , cord-276616-odmnvv7m 67 40 1961 1961 CD cord-276616-odmnvv7m 67 41 ) ) -RRB- cord-276616-odmnvv7m 67 42 ; ; : cord-276616-odmnvv7m 67 43 in in IN cord-276616-odmnvv7m 67 44 hamsters hamster NNS cord-276616-odmnvv7m 67 45 the the DT cord-276616-odmnvv7m 67 46 disease disease NN cord-276616-odmnvv7m 67 47 may may MD cord-276616-odmnvv7m 67 48 proceed proceed VB cord-276616-odmnvv7m 67 49 even even RB cord-276616-odmnvv7m 67 50 more more RBR cord-276616-odmnvv7m 67 51 rapidly rapidly RB cord-276616-odmnvv7m 67 52 ( ( -LRB- cord-276616-odmnvv7m 67 53 Kimberlin Kimberlin NNP cord-276616-odmnvv7m 67 54 and and CC cord-276616-odmnvv7m 67 55 Walker Walker NNP cord-276616-odmnvv7m 67 56 , , , cord-276616-odmnvv7m 67 57 1977 1977 CD cord-276616-odmnvv7m 67 58 ) ) -RRB- cord-276616-odmnvv7m 67 59 . . . cord-276616-odmnvv7m 68 1 Contributing contribute VBG cord-276616-odmnvv7m 68 2 to to IN cord-276616-odmnvv7m 68 3 the the DT cord-276616-odmnvv7m 68 4 incubation incubation NN cord-276616-odmnvv7m 68 5 period period NN cord-276616-odmnvv7m 68 6 is be VBZ cord-276616-odmnvv7m 68 7 the the DT cord-276616-odmnvv7m 68 8 phenomenon phenomenon NN cord-276616-odmnvv7m 68 9 that that WDT cord-276616-odmnvv7m 68 10 has have VBZ cord-276616-odmnvv7m 68 11 been be VBN cord-276616-odmnvv7m 68 12 termed term VBN cord-276616-odmnvv7m 68 13 the the DT cord-276616-odmnvv7m 68 14 ' ' `` cord-276616-odmnvv7m 68 15 zero zero CD cord-276616-odmnvv7m 68 16 phase phase NN cord-276616-odmnvv7m 68 17 ' ' '' cord-276616-odmnvv7m 68 18 ( ( -LRB- cord-276616-odmnvv7m 68 19 Dickinson Dickinson NNP cord-276616-odmnvv7m 68 20 and and CC cord-276616-odmnvv7m 68 21 Outram Outram NNP cord-276616-odmnvv7m 68 22 , , , cord-276616-odmnvv7m 68 23 1979 1979 CD cord-276616-odmnvv7m 68 24 ) ) -RRB- cord-276616-odmnvv7m 68 25 . . . cord-276616-odmnvv7m 69 1 This this DT cord-276616-odmnvv7m 69 2 is be VBZ cord-276616-odmnvv7m 69 3 a a DT cord-276616-odmnvv7m 69 4 period period NN cord-276616-odmnvv7m 69 5 after after IN cord-276616-odmnvv7m 69 6 infection infection NN cord-276616-odmnvv7m 69 7 when when WRB cord-276616-odmnvv7m 69 8 no no DT cord-276616-odmnvv7m 69 9 infectivity infectivity NN cord-276616-odmnvv7m 69 10 can can MD cord-276616-odmnvv7m 69 11 be be VB cord-276616-odmnvv7m 69 12 demonstrated demonstrate VBN cord-276616-odmnvv7m 69 13 from from IN cord-276616-odmnvv7m 69 14 such such JJ cord-276616-odmnvv7m 69 15 organs organ NNS cord-276616-odmnvv7m 69 16 as as IN cord-276616-odmnvv7m 69 17 the the DT cord-276616-odmnvv7m 69 18 brain brain NN cord-276616-odmnvv7m 69 19 , , , cord-276616-odmnvv7m 69 20 spleen spleen NN cord-276616-odmnvv7m 69 21 and and CC cord-276616-odmnvv7m 69 22 fiver fiver NN cord-276616-odmnvv7m 69 23 . . . cord-276616-odmnvv7m 70 1 The the DT cord-276616-odmnvv7m 70 2 severity severity NN cord-276616-odmnvv7m 70 3 and and CC cord-276616-odmnvv7m 70 4 type type NN cord-276616-odmnvv7m 70 5 of of IN cord-276616-odmnvv7m 70 6 lesions lesion NNS cord-276616-odmnvv7m 70 7 vary vary VBP cord-276616-odmnvv7m 70 8 , , , cord-276616-odmnvv7m 70 9 and and CC cord-276616-odmnvv7m 70 10 a a DT cord-276616-odmnvv7m 70 11 quantitative quantitative JJ cord-276616-odmnvv7m 70 12 assessment assessment NN cord-276616-odmnvv7m 70 13 of of IN cord-276616-odmnvv7m 70 14 these these DT cord-276616-odmnvv7m 70 15 can can MD cord-276616-odmnvv7m 70 16 be be VB cord-276616-odmnvv7m 70 17 used use VBN cord-276616-odmnvv7m 70 18 as as IN cord-276616-odmnvv7m 70 19 a a DT cord-276616-odmnvv7m 70 20 characteristic characteristic NN cord-276616-odmnvv7m 70 21 of of IN cord-276616-odmnvv7m 70 22 the the DT cord-276616-odmnvv7m 70 23 biological biological JJ cord-276616-odmnvv7m 70 24 behaviour behaviour NN cord-276616-odmnvv7m 70 25 of of IN cord-276616-odmnvv7m 70 26 scrapie scrapie NN cord-276616-odmnvv7m 70 27 isolates isolate NNS cord-276616-odmnvv7m 70 28 . . . cord-276616-odmnvv7m 71 1 Transmission transmission NN cord-276616-odmnvv7m 71 2 experiments experiment NNS cord-276616-odmnvv7m 71 3 in in IN cord-276616-odmnvv7m 71 4 inbred inbred JJ cord-276616-odmnvv7m 71 5 mice mouse NNS cord-276616-odmnvv7m 71 6 have have VBP cord-276616-odmnvv7m 71 7 shown show VBN cord-276616-odmnvv7m 71 8 that that IN cord-276616-odmnvv7m 71 9 there there EX cord-276616-odmnvv7m 71 10 are be VBP cord-276616-odmnvv7m 71 11 mixtures mixture NNS cord-276616-odmnvv7m 71 12 of of IN cord-276616-odmnvv7m 71 13 agents agent NNS cord-276616-odmnvv7m 71 14 in in IN cord-276616-odmnvv7m 71 15 a a DT cord-276616-odmnvv7m 71 16 natural natural JJ cord-276616-odmnvv7m 71 17 case case NN cord-276616-odmnvv7m 71 18 of of IN cord-276616-odmnvv7m 71 19 scrapie scrapie NN cord-276616-odmnvv7m 71 20 in in IN cord-276616-odmnvv7m 71 21 a a DT cord-276616-odmnvv7m 71 22 sheep sheep NN cord-276616-odmnvv7m 71 23 , , , cord-276616-odmnvv7m 71 24 and and CC cord-276616-odmnvv7m 71 25 as as RB cord-276616-odmnvv7m 71 26 many many JJ cord-276616-odmnvv7m 71 27 as as IN cord-276616-odmnvv7m 71 28 15 15 CD cord-276616-odmnvv7m 71 29 distinct distinct JJ cord-276616-odmnvv7m 71 30 stains stain NNS cord-276616-odmnvv7m 71 31 have have VBP cord-276616-odmnvv7m 71 32 been be VBN cord-276616-odmnvv7m 71 33 so so RB cord-276616-odmnvv7m 71 34 identified identify VBN cord-276616-odmnvv7m 71 35 . . . cord-276616-odmnvv7m 72 1 At at RB cord-276616-odmnvv7m 72 2 least least JJS cord-276616-odmnvv7m 72 3 four four CD cord-276616-odmnvv7m 72 4 murine murine JJ cord-276616-odmnvv7m 72 5 strains strain NNS cord-276616-odmnvv7m 72 6 of of IN cord-276616-odmnvv7m 72 7 scrapie scrapie NN cord-276616-odmnvv7m 72 8 have have VBP cord-276616-odmnvv7m 72 9 been be VBN cord-276616-odmnvv7m 72 10 derived derive VBN cord-276616-odmnvv7m 72 11 from from IN cord-276616-odmnvv7m 72 12 the the DT cord-276616-odmnvv7m 72 13 ' ' `` cord-276616-odmnvv7m 72 14 drowsy drowsy JJ cord-276616-odmnvv7m 72 15 goat goat NN cord-276616-odmnvv7m 72 16 ' ' '' cord-276616-odmnvv7m 72 17 source source NN cord-276616-odmnvv7m 72 18 , , , cord-276616-odmnvv7m 72 19 the the DT cord-276616-odmnvv7m 72 20 result result NN cord-276616-odmnvv7m 72 21 of of IN cord-276616-odmnvv7m 72 22 scrapie scrapie NN cord-276616-odmnvv7m 72 23 transmission transmission NN cord-276616-odmnvv7m 72 24 experiments experiment NNS cord-276616-odmnvv7m 72 25 in in IN cord-276616-odmnvv7m 72 26 goats goat NNS cord-276616-odmnvv7m 72 27 ( ( -LRB- cord-276616-odmnvv7m 72 28 Bruce Bruce NNP cord-276616-odmnvv7m 72 29 and and CC cord-276616-odmnvv7m 72 30 Dickinson Dickinson NNP cord-276616-odmnvv7m 72 31 , , , cord-276616-odmnvv7m 72 32 1979 1979 CD cord-276616-odmnvv7m 72 33 ) ) -RRB- cord-276616-odmnvv7m 72 34 . . . cord-276616-odmnvv7m 73 1 Such such PDT cord-276616-odmnvv7m 73 2 a a DT cord-276616-odmnvv7m 73 3 spectrum spectrum NN cord-276616-odmnvv7m 73 4 of of IN cord-276616-odmnvv7m 73 5 behaviour behaviour NN cord-276616-odmnvv7m 73 6 by by IN cord-276616-odmnvv7m 73 7 different different JJ cord-276616-odmnvv7m 73 8 isolates isolate NNS cord-276616-odmnvv7m 73 9 of of IN cord-276616-odmnvv7m 73 10 field field NN cord-276616-odmnvv7m 73 11 cases case NNS cord-276616-odmnvv7m 73 12 would would MD cord-276616-odmnvv7m 73 13 be be VB cord-276616-odmnvv7m 73 14 expected expect VBN cord-276616-odmnvv7m 73 15 in in IN cord-276616-odmnvv7m 73 16 studies study NNS cord-276616-odmnvv7m 73 17 with with IN cord-276616-odmnvv7m 73 18 the the DT cord-276616-odmnvv7m 73 19 spongiform spongiform JJ cord-276616-odmnvv7m 73 20 encephalopathies encephalopathy NNS cord-276616-odmnvv7m 73 21 of of IN cord-276616-odmnvv7m 73 22 other other JJ cord-276616-odmnvv7m 73 23 species specie NNS cord-276616-odmnvv7m 73 24 , , , cord-276616-odmnvv7m 73 25 especially especially RB cord-276616-odmnvv7m 73 26 if if IN cord-276616-odmnvv7m 73 27 they -PRON- PRP cord-276616-odmnvv7m 73 28 truly truly RB cord-276616-odmnvv7m 73 29 represent represent VBP cord-276616-odmnvv7m 73 30 passages passage NNS cord-276616-odmnvv7m 73 31 of of IN cord-276616-odmnvv7m 73 32 the the DT cord-276616-odmnvv7m 73 33 scrapie scrapie NN cord-276616-odmnvv7m 73 34 agent agent NN cord-276616-odmnvv7m 73 35 . . . cord-276616-odmnvv7m 74 1 The the DT cord-276616-odmnvv7m 74 2 agent agent NN cord-276616-odmnvv7m 74 3 causing cause VBG cord-276616-odmnvv7m 74 4 BSE BSE NNP cord-276616-odmnvv7m 74 5 is be VBZ cord-276616-odmnvv7m 74 6 transmissible transmissible JJ cord-276616-odmnvv7m 74 7 to to IN cord-276616-odmnvv7m 74 8 mice mouse NNS cord-276616-odmnvv7m 74 9 and and CC cord-276616-odmnvv7m 74 10 can can MD cord-276616-odmnvv7m 74 11 be be VB cord-276616-odmnvv7m 74 12 orally orally RB cord-276616-odmnvv7m 74 13 transmitted transmit VBN cord-276616-odmnvv7m 74 14 to to IN cord-276616-odmnvv7m 74 15 C57B1 C57B1 NNP cord-276616-odmnvv7m 74 16 mice mouse NNS cord-276616-odmnvv7m 74 17 by by IN cord-276616-odmnvv7m 74 18 feeding feed VBG cord-276616-odmnvv7m 74 19 BSE BSE NNP cord-276616-odmnvv7m 74 20 brain brain NN cord-276616-odmnvv7m 74 21 ( ( -LRB- cord-276616-odmnvv7m 74 22 Barlow Barlow NNP cord-276616-odmnvv7m 74 23 and and CC cord-276616-odmnvv7m 74 24 Middleton Middleton NNP cord-276616-odmnvv7m 74 25 , , , cord-276616-odmnvv7m 74 26 1991 1991 CD cord-276616-odmnvv7m 74 27 ) ) -RRB- cord-276616-odmnvv7m 74 28 . . . cord-276616-odmnvv7m 75 1 However however RB cord-276616-odmnvv7m 75 2 , , , cord-276616-odmnvv7m 75 3 the the DT cord-276616-odmnvv7m 75 4 nature nature NN cord-276616-odmnvv7m 75 5 and and CC cord-276616-odmnvv7m 75 6 distribution distribution NN cord-276616-odmnvv7m 75 7 of of IN cord-276616-odmnvv7m 75 8 pathological pathological JJ cord-276616-odmnvv7m 75 9 lesions lesion NNS cord-276616-odmnvv7m 75 10 in in IN cord-276616-odmnvv7m 75 11 experimentally experimentally RB cord-276616-odmnvv7m 75 12 infected infect VBN cord-276616-odmnvv7m 75 13 mice mouse NNS cord-276616-odmnvv7m 75 14 were be VBD cord-276616-odmnvv7m 75 15 similar similar JJ cord-276616-odmnvv7m 75 16 even even RB cord-276616-odmnvv7m 75 17 when when WRB cord-276616-odmnvv7m 75 18 the the DT cord-276616-odmnvv7m 75 19 source source NN cord-276616-odmnvv7m 75 20 of of IN cord-276616-odmnvv7m 75 21 the the DT cord-276616-odmnvv7m 75 22 infection infection NN cord-276616-odmnvv7m 75 23 was be VBD cord-276616-odmnvv7m 75 24 different different JJ cord-276616-odmnvv7m 75 25 species specie NNS cord-276616-odmnvv7m 75 26 of of IN cord-276616-odmnvv7m 75 27 bovidae bovidae NN cord-276616-odmnvv7m 75 28 , , , cord-276616-odmnvv7m 75 29 and and CC cord-276616-odmnvv7m 75 30 there there EX cord-276616-odmnvv7m 75 31 was be VBD cord-276616-odmnvv7m 75 32 no no DT cord-276616-odmnvv7m 75 33 evidence evidence NN cord-276616-odmnvv7m 75 34 of of IN cord-276616-odmnvv7m 75 35 strain strain NN cord-276616-odmnvv7m 75 36 variation variation NN cord-276616-odmnvv7m 75 37 . . . cord-276616-odmnvv7m 76 1 Although although IN cord-276616-odmnvv7m 76 2 transmissible transmissible JJ cord-276616-odmnvv7m 76 3 encephalopathy encephalopathy NN cord-276616-odmnvv7m 76 4 is be VBZ cord-276616-odmnvv7m 76 5 not not RB cord-276616-odmnvv7m 76 6 observed observe VBN cord-276616-odmnvv7m 76 7 naturally naturally RB cord-276616-odmnvv7m 76 8 in in IN cord-276616-odmnvv7m 76 9 pigs pig NNS cord-276616-odmnvv7m 76 10 , , , cord-276616-odmnvv7m 76 11 it -PRON- PRP cord-276616-odmnvv7m 76 12 can can MD cord-276616-odmnvv7m 76 13 be be VB cord-276616-odmnvv7m 76 14 produced produce VBN cord-276616-odmnvv7m 76 15 experimentally experimentally RB cord-276616-odmnvv7m 76 16 in in IN cord-276616-odmnvv7m 76 17 this this DT cord-276616-odmnvv7m 76 18 species species NN cord-276616-odmnvv7m 76 19 ) ) -RRB- cord-276616-odmnvv7m 76 20 by by IN cord-276616-odmnvv7m 76 21 transmission transmission NN cord-276616-odmnvv7m 76 22 of of IN cord-276616-odmnvv7m 76 23 BSE BSE NNP cord-276616-odmnvv7m 76 24 . . . cord-276616-odmnvv7m 77 1 Differently differently RB cord-276616-odmnvv7m 77 2 located locate VBN cord-276616-odmnvv7m 77 3 neural neural JJ cord-276616-odmnvv7m 77 4 lesions lesion NNS cord-276616-odmnvv7m 77 5 and and CC cord-276616-odmnvv7m 77 6 different different JJ cord-276616-odmnvv7m 77 7 signs sign NNS cord-276616-odmnvv7m 77 8 from from IN cord-276616-odmnvv7m 77 9 those those DT cord-276616-odmnvv7m 77 10 seen see VBN cord-276616-odmnvv7m 77 11 in in IN cord-276616-odmnvv7m 77 12 TME TME NNP cord-276616-odmnvv7m 77 13 were be VBD cord-276616-odmnvv7m 77 14 observed observe VBN cord-276616-odmnvv7m 77 15 in in IN cord-276616-odmnvv7m 77 16 mink mink NN cord-276616-odmnvv7m 77 17 receiving receive VBG cord-276616-odmnvv7m 77 18 brain brain NN cord-276616-odmnvv7m 77 19 tissue tissue NN cord-276616-odmnvv7m 77 20 from from IN cord-276616-odmnvv7m 77 21 BSE BSE NNP cord-276616-odmnvv7m 77 22 - - HYPH cord-276616-odmnvv7m 77 23 infected infect VBN cord-276616-odmnvv7m 77 24 cattle cattle NNS cord-276616-odmnvv7m 77 25 . . . cord-276616-odmnvv7m 78 1 Transmission transmission NN cord-276616-odmnvv7m 78 2 was be VBD cord-276616-odmnvv7m 78 3 effected effect VBN cord-276616-odmnvv7m 78 4 both both DT cord-276616-odmnvv7m 78 5 parenterally parenterally NNS cord-276616-odmnvv7m 78 6 and and CC cord-276616-odmnvv7m 78 7 orally orally RB cord-276616-odmnvv7m 79 1 ( ( -LRB- cord-276616-odmnvv7m 79 2 Robinson Robinson NNP cord-276616-odmnvv7m 79 3 et et NNP cord-276616-odmnvv7m 79 4 al al NNP cord-276616-odmnvv7m 79 5 . . NNP cord-276616-odmnvv7m 79 6 , , , cord-276616-odmnvv7m 79 7 1994 1994 CD cord-276616-odmnvv7m 79 8 ) ) -RRB- cord-276616-odmnvv7m 79 9 . . . cord-276616-odmnvv7m 80 1 In in IN cord-276616-odmnvv7m 80 2 transmission transmission NN cord-276616-odmnvv7m 80 3 experiments experiment NNS cord-276616-odmnvv7m 80 4 with with IN cord-276616-odmnvv7m 80 5 CJD CJD NNP cord-276616-odmnvv7m 80 6 and and CC cord-276616-odmnvv7m 80 7 Kuru Kuru NNP cord-276616-odmnvv7m 80 8 , , , cord-276616-odmnvv7m 80 9 chimpanzees chimpanzee NNS cord-276616-odmnvv7m 80 10 and and CC cord-276616-odmnvv7m 80 11 squirrel squirrel NN cord-276616-odmnvv7m 80 12 monkeys monkey NNS cord-276616-odmnvv7m 80 13 are be VBP cord-276616-odmnvv7m 80 14 the the DT cord-276616-odmnvv7m 80 15 most most RBS cord-276616-odmnvv7m 80 16 sensitive sensitive JJ cord-276616-odmnvv7m 80 17 , , , cord-276616-odmnvv7m 80 18 and and CC cord-276616-odmnvv7m 80 19 are be VBP cord-276616-odmnvv7m 80 20 uniformly uniformly RB cord-276616-odmnvv7m 80 21 susceptible susceptible JJ cord-276616-odmnvv7m 80 22 , , , cord-276616-odmnvv7m 80 23 but but CC cord-276616-odmnvv7m 80 24 the the DT cord-276616-odmnvv7m 80 25 disease disease NN cord-276616-odmnvv7m 80 26 has have VBZ cord-276616-odmnvv7m 80 27 also also RB cord-276616-odmnvv7m 80 28 been be VBN cord-276616-odmnvv7m 80 29 transmitted transmit VBN cord-276616-odmnvv7m 80 30 to to IN cord-276616-odmnvv7m 80 31 laboratory laboratory NN cord-276616-odmnvv7m 80 32 animals animal NNS cord-276616-odmnvv7m 80 33 . . . cord-276616-odmnvv7m 81 1 Guinea guinea NN cord-276616-odmnvv7m 81 2 - - HYPH cord-276616-odmnvv7m 81 3 pigs pig NNS cord-276616-odmnvv7m 81 4 died die VBD cord-276616-odmnvv7m 81 5 quite quite RB cord-276616-odmnvv7m 81 6 rapidly rapidly RB cord-276616-odmnvv7m 81 7 of of IN cord-276616-odmnvv7m 81 8 hydrocephalus hydrocephalus NN cord-276616-odmnvv7m 81 9 , , , cord-276616-odmnvv7m 81 10 which which WDT cord-276616-odmnvv7m 81 11 did do VBD cord-276616-odmnvv7m 81 12 not not RB cord-276616-odmnvv7m 81 13 appear appear VB cord-276616-odmnvv7m 81 14 to to TO cord-276616-odmnvv7m 81 15 be be VB cord-276616-odmnvv7m 81 16 due due JJ cord-276616-odmnvv7m 81 17 to to IN cord-276616-odmnvv7m 81 18 the the DT cord-276616-odmnvv7m 81 19 presence presence NN cord-276616-odmnvv7m 81 20 of of IN cord-276616-odmnvv7m 81 21 any any DT cord-276616-odmnvv7m 81 22 additional additional JJ cord-276616-odmnvv7m 81 23 conventional conventional JJ cord-276616-odmnvv7m 81 24 virus virus NN cord-276616-odmnvv7m 81 25 in in IN cord-276616-odmnvv7m 81 26 the the DT cord-276616-odmnvv7m 81 27 inocuhim inocuhim NN cord-276616-odmnvv7m 81 28 . . . cord-276616-odmnvv7m 82 1 Hamsters hamster NNS cord-276616-odmnvv7m 82 2 seemed seem VBD cord-276616-odmnvv7m 82 3 uniformly uniformly RB cord-276616-odmnvv7m 82 4 susceptible susceptible JJ cord-276616-odmnvv7m 82 5 and and CC cord-276616-odmnvv7m 82 6 developed developed JJ cord-276616-odmnvv7m 82 7 paralysis paralysis NN cord-276616-odmnvv7m 82 8 of of IN cord-276616-odmnvv7m 82 9 the the DT cord-276616-odmnvv7m 82 10 hind hind NN cord-276616-odmnvv7m 82 11 limbs limb NNS cord-276616-odmnvv7m 82 12 and and CC cord-276616-odmnvv7m 82 13 skin skin NN cord-276616-odmnvv7m 82 14 hypersensitivity hypersensitivity NN cord-276616-odmnvv7m 82 15 . . . cord-276616-odmnvv7m 83 1 Mice mouse NNS cord-276616-odmnvv7m 83 2 that that WDT cord-276616-odmnvv7m 83 3 were be VBD cord-276616-odmnvv7m 83 4 infected infect VBN cord-276616-odmnvv7m 83 5 with with IN cord-276616-odmnvv7m 83 6 guinea guinea NN cord-276616-odmnvv7m 83 7 - - HYPH cord-276616-odmnvv7m 83 8 pig pig NN cord-276616-odmnvv7m 83 9 - - HYPH cord-276616-odmnvv7m 83 10 derived derive VBN cord-276616-odmnvv7m 83 11 CJD CJD NNP cord-276616-odmnvv7m 83 12 developed develop VBD cord-276616-odmnvv7m 83 13 signs sign NNS cord-276616-odmnvv7m 83 14 of of IN cord-276616-odmnvv7m 83 15 skin skin NN cord-276616-odmnvv7m 83 16 hypersensitivity hypersensitivity NN cord-276616-odmnvv7m 83 17 and and CC cord-276616-odmnvv7m 83 18 locomotor locomotor NN cord-276616-odmnvv7m 83 19 problems problem NNS cord-276616-odmnvv7m 83 20 after after IN cord-276616-odmnvv7m 83 21 a a DT cord-276616-odmnvv7m 83 22 long long JJ cord-276616-odmnvv7m 83 23 latent latent JJ cord-276616-odmnvv7m 83 24 period period NN cord-276616-odmnvv7m 83 25 ( ( -LRB- cord-276616-odmnvv7m 83 26 Manuelidis Manuelidis NNP cord-276616-odmnvv7m 83 27 and and CC cord-276616-odmnvv7m 83 28 Manuelidis Manuelidis NNP cord-276616-odmnvv7m 83 29 , , , cord-276616-odmnvv7m 83 30 1979 1979 CD cord-276616-odmnvv7m 83 31 ) ) -RRB- cord-276616-odmnvv7m 83 32 . . . cord-276616-odmnvv7m 84 1 Not not RB cord-276616-odmnvv7m 84 2 all all DT cord-276616-odmnvv7m 84 3 transmissible transmissible JJ cord-276616-odmnvv7m 84 4 spongiform spongiform JJ cord-276616-odmnvv7m 84 5 encephalopathies encephalopathy NNS cord-276616-odmnvv7m 84 6 are be VBP cord-276616-odmnvv7m 84 7 due due JJ cord-276616-odmnvv7m 84 8 to to IN cord-276616-odmnvv7m 84 9 scrapie scrapie NN cord-276616-odmnvv7m 84 10 - - HYPH cord-276616-odmnvv7m 84 11 like like JJ cord-276616-odmnvv7m 84 12 agents agent NNS cord-276616-odmnvv7m 84 13 . . . cord-276616-odmnvv7m 85 1 Mice mouse NNS cord-276616-odmnvv7m 85 2 , , , cord-276616-odmnvv7m 85 3 homozygous homozygous JJ cord-276616-odmnvv7m 85 4 for for IN cord-276616-odmnvv7m 85 5 the the DT cord-276616-odmnvv7m 85 6 grey grey JJ cord-276616-odmnvv7m 85 7 tremor tremor NN cord-276616-odmnvv7m 85 8 trait trait NN cord-276616-odmnvv7m 85 9 , , , cord-276616-odmnvv7m 85 10 develop develop VB cord-276616-odmnvv7m 85 11 a a DT cord-276616-odmnvv7m 85 12 transmissible transmissible JJ cord-276616-odmnvv7m 85 13 encephalopathy encephalopathy NN cord-276616-odmnvv7m 85 14 that that WDT cord-276616-odmnvv7m 85 15 is be VBZ cord-276616-odmnvv7m 85 16 not not RB cord-276616-odmnvv7m 85 17 accompanied accompany VBN cord-276616-odmnvv7m 85 18 with with IN cord-276616-odmnvv7m 85 19 the the DT cord-276616-odmnvv7m 85 20 coat coat NN cord-276616-odmnvv7m 85 21 pigmentation pigmentation NN cord-276616-odmnvv7m 85 22 , , , cord-276616-odmnvv7m 85 23 the the DT cord-276616-odmnvv7m 85 24 seizures seizure NNS cord-276616-odmnvv7m 85 25 , , , cord-276616-odmnvv7m 85 26 tremors tremor NNS cord-276616-odmnvv7m 85 27 and and CC cord-276616-odmnvv7m 85 28 ataxia ataxia NN cord-276616-odmnvv7m 85 29 characteristic characteristic NN cord-276616-odmnvv7m 85 30 of of IN cord-276616-odmnvv7m 85 31 the the DT cord-276616-odmnvv7m 85 32 clinical clinical JJ cord-276616-odmnvv7m 85 33 disease disease NN cord-276616-odmnvv7m 85 34 in in IN cord-276616-odmnvv7m 85 35 the the DT cord-276616-odmnvv7m 85 36 donor donor NN cord-276616-odmnvv7m 85 37 animals animal NNS cord-276616-odmnvv7m 85 38 . . . cord-276616-odmnvv7m 86 1 Further further RB cord-276616-odmnvv7m 86 2 , , , cord-276616-odmnvv7m 86 3 brain brain NN cord-276616-odmnvv7m 86 4 homogenates homogenate NNS cord-276616-odmnvv7m 86 5 from from IN cord-276616-odmnvv7m 86 6 these these DT cord-276616-odmnvv7m 86 7 mice mouse NNS cord-276616-odmnvv7m 86 8 do do VBP cord-276616-odmnvv7m 86 9 not not RB cord-276616-odmnvv7m 86 10 show show VB cord-276616-odmnvv7m 86 11 the the DT cord-276616-odmnvv7m 86 12 presence presence NN cord-276616-odmnvv7m 86 13 of of IN cord-276616-odmnvv7m 86 14 proteinase proteinase NN cord-276616-odmnvv7m 86 15 - - HYPH cord-276616-odmnvv7m 86 16 K k NN cord-276616-odmnvv7m 86 17 - - HYPH cord-276616-odmnvv7m 86 18 resistant resistant JJ cord-276616-odmnvv7m 86 19 PrPSc prpsc NN cord-276616-odmnvv7m 87 1 ( ( -LRB- cord-276616-odmnvv7m 87 2 Bendheim Bendheim NNP cord-276616-odmnvv7m 87 3 et et NNP cord-276616-odmnvv7m 87 4 aL aL NNP cord-276616-odmnvv7m 87 5 , , , cord-276616-odmnvv7m 87 6 1988 1988 CD cord-276616-odmnvv7m 87 7 ) ) -RRB- cord-276616-odmnvv7m 87 8 . . . cord-276616-odmnvv7m 87 9 ' ' '' cord-276616-odmnvv7m 88 1 Most Most JJS cord-276616-odmnvv7m 88 2 neurological neurological JJ cord-276616-odmnvv7m 88 3 diseases disease NNS cord-276616-odmnvv7m 88 4 follow follow VBP cord-276616-odmnvv7m 88 5 the the DT cord-276616-odmnvv7m 88 6 same same JJ cord-276616-odmnvv7m 88 7 general general JJ cord-276616-odmnvv7m 88 8 sequence sequence NN cord-276616-odmnvv7m 88 9 of of IN cord-276616-odmnvv7m 88 10 events event NNS cord-276616-odmnvv7m 88 11 : : : cord-276616-odmnvv7m 88 12 excitement excitement NN cord-276616-odmnvv7m 88 13 - - HYPH cord-276616-odmnvv7m 88 14 , , , cord-276616-odmnvv7m 88 15 hyperaesthesia hyperaesthesia NNP cord-276616-odmnvv7m 88 16 -~ -~ NNP cord-276616-odmnvv7m 88 17 dementia dementia NN cord-276616-odmnvv7m 88 18 ~ ~ CD cord-276616-odmnvv7m 88 19 dullness dullness NN cord-276616-odmnvv7m 88 20 - - HYPH cord-276616-odmnvv7m 88 21 * * NN cord-276616-odmnvv7m 88 22 coma coma NN cord-276616-odmnvv7m 88 23 - - : cord-276616-odmnvv7m 88 24 , , , cord-276616-odmnvv7m 88 25 death death NN cord-276616-odmnvv7m 88 26 ; ; . cord-276616-odmnvv7m 89 1 incoordination incoordination NN cord-276616-odmnvv7m 89 2 -~ -~ . cord-276616-odmnvv7m 90 1 ataxia ataxia NN cord-276616-odmnvv7m 90 2 - - HYPH cord-276616-odmnvv7m 90 3 , , , cord-276616-odmnvv7m 90 4 paresis paresis NN cord-276616-odmnvv7m 90 5 - - HYPH cord-276616-odmnvv7m 90 6 , , , cord-276616-odmnvv7m 90 7 paralysis paralysis NN cord-276616-odmnvv7m 90 8 . . . cord-276616-odmnvv7m 91 1 It -PRON- PRP cord-276616-odmnvv7m 91 2 is be VBZ cord-276616-odmnvv7m 91 3 the the DT cord-276616-odmnvv7m 91 4 duration duration NN cord-276616-odmnvv7m 91 5 of of IN cord-276616-odmnvv7m 91 6 each each DT cord-276616-odmnvv7m 91 7 phase phase NN cord-276616-odmnvv7m 91 8 which which WDT cord-276616-odmnvv7m 91 9 varies vary VBZ cord-276616-odmnvv7m 91 10 with with IN cord-276616-odmnvv7m 91 11 the the DT cord-276616-odmnvv7m 91 12 cause cause NN cord-276616-odmnvv7m 91 13 and and CC cord-276616-odmnvv7m 91 14 the the DT cord-276616-odmnvv7m 91 15 neural neural JJ cord-276616-odmnvv7m 91 16 centres centre NNS cord-276616-odmnvv7m 91 17 critically critically RB cord-276616-odmnvv7m 91 18 damaged damage VBN cord-276616-odmnvv7m 91 19 ' ' '' cord-276616-odmnvv7m 91 20 ( ( -LRB- cord-276616-odmnvv7m 91 21 R.M. R.M. NNP cord-276616-odmnvv7m 91 22 Barlow Barlow NNP cord-276616-odmnvv7m 91 23 , , , cord-276616-odmnvv7m 91 24 personal personal JJ cord-276616-odmnvv7m 91 25 communication communication NN cord-276616-odmnvv7m 91 26 , , , cord-276616-odmnvv7m 91 27 1994 1994 CD cord-276616-odmnvv7m 91 28 ) ) -RRB- cord-276616-odmnvv7m 91 29 . . . cord-276616-odmnvv7m 92 1 The the DT cord-276616-odmnvv7m 92 2 signs sign NNS cord-276616-odmnvv7m 92 3 seen see VBN cord-276616-odmnvv7m 92 4 in in IN cord-276616-odmnvv7m 92 5 scrapie scrapie NN cord-276616-odmnvv7m 92 6 , , , cord-276616-odmnvv7m 92 7 which which WDT cord-276616-odmnvv7m 92 8 are be VBP cord-276616-odmnvv7m 92 9 not not RB cord-276616-odmnvv7m 92 10 specific specific JJ cord-276616-odmnvv7m 92 11 , , , cord-276616-odmnvv7m 92 12 reflect reflect VB cord-276616-odmnvv7m 92 13 damage damage NN cord-276616-odmnvv7m 92 14 to to IN cord-276616-odmnvv7m 92 15 the the DT cord-276616-odmnvv7m 92 16 neural neural JJ cord-276616-odmnvv7m 92 17 centres centre NNS cord-276616-odmnvv7m 92 18 , , , cord-276616-odmnvv7m 92 19 following follow VBG cord-276616-odmnvv7m 92 20 the the DT cord-276616-odmnvv7m 92 21 two two CD cord-276616-odmnvv7m 92 22 alternative alternative JJ cord-276616-odmnvv7m 92 23 progressions progression NNS cord-276616-odmnvv7m 92 24 noted note VBN cord-276616-odmnvv7m 92 25 above above RB cord-276616-odmnvv7m 92 26 . . . cord-276616-odmnvv7m 93 1 For for IN cord-276616-odmnvv7m 93 2 instance instance NN cord-276616-odmnvv7m 93 3 , , , cord-276616-odmnvv7m 93 4 with with IN cord-276616-odmnvv7m 93 5 reference reference NN cord-276616-odmnvv7m 93 6 to to IN cord-276616-odmnvv7m 93 7 the the DT cord-276616-odmnvv7m 93 8 louping louping NN cord-276616-odmnvv7m 93 9 - - HYPH cord-276616-odmnvv7m 93 10 ill ill JJ cord-276616-odmnvv7m 93 11 vaccination vaccination NN cord-276616-odmnvv7m 93 12 trials trial NNS cord-276616-odmnvv7m 93 13 in in IN cord-276616-odmnvv7m 93 14 the the DT cord-276616-odmnvv7m 93 15 1930s 1930 NNS cord-276616-odmnvv7m 93 16 , , , cord-276616-odmnvv7m 93 17 louping louping NN cord-276616-odmnvv7m 93 18 - - HYPH cord-276616-odmnvv7m 93 19 ill ill JJ cord-276616-odmnvv7m 93 20 itself -PRON- PRP cord-276616-odmnvv7m 93 21 is be VBZ cord-276616-odmnvv7m 93 22 also also RB cord-276616-odmnvv7m 93 23 characterized characterize VBN cord-276616-odmnvv7m 93 24 by by IN cord-276616-odmnvv7m 93 25 muscle muscle NN cord-276616-odmnvv7m 93 26 tremor tremor NN cord-276616-odmnvv7m 93 27 and and CC cord-276616-odmnvv7m 93 28 incoordination incoordination NN cord-276616-odmnvv7m 93 29 of of IN cord-276616-odmnvv7m 93 30 the the DT cord-276616-odmnvv7m 93 31 hind hind NN cord-276616-odmnvv7m 93 32 limbs limb NNS cord-276616-odmnvv7m 93 33 . . . cord-276616-odmnvv7m 94 1 There there EX cord-276616-odmnvv7m 94 2 may may MD cord-276616-odmnvv7m 94 3 be be VB cord-276616-odmnvv7m 94 4 hypersensitivity hypersensitivity NN cord-276616-odmnvv7m 94 5 to to IN cord-276616-odmnvv7m 94 6 noise noise NN cord-276616-odmnvv7m 94 7 and and CC cord-276616-odmnvv7m 94 8 touch touch NN cord-276616-odmnvv7m 94 9 . . . cord-276616-odmnvv7m 95 1 Unlike unlike IN cord-276616-odmnvv7m 95 2 scrapie scrapie NN cord-276616-odmnvv7m 95 3 , , , cord-276616-odmnvv7m 95 4 the the DT cord-276616-odmnvv7m 95 5 disease disease NN cord-276616-odmnvv7m 95 6 progresses progress VBZ cord-276616-odmnvv7m 95 7 more more RBR cord-276616-odmnvv7m 95 8 rapidly rapidly RB cord-276616-odmnvv7m 95 9 . . . cord-276616-odmnvv7m 96 1 Death death NN cord-276616-odmnvv7m 96 2 follows follow VBZ cord-276616-odmnvv7m 96 3 within within IN cord-276616-odmnvv7m 96 4 7 7 CD cord-276616-odmnvv7m 96 5 - - SYM cord-276616-odmnvv7m 96 6 10 10 CD cord-276616-odmnvv7m 96 7 days day NNS cord-276616-odmnvv7m 96 8 of of IN cord-276616-odmnvv7m 96 9 signs sign NNS cord-276616-odmnvv7m 96 10 of of IN cord-276616-odmnvv7m 96 11 developing develop VBG cord-276616-odmnvv7m 96 12 . . . cord-276616-odmnvv7m 97 1 Some some DT cord-276616-odmnvv7m 97 2 of of IN cord-276616-odmnvv7m 97 3 the the DT cord-276616-odmnvv7m 97 4 signs sign NNS cord-276616-odmnvv7m 97 5 seen see VBN cord-276616-odmnvv7m 97 6 in in IN cord-276616-odmnvv7m 97 7 scrapie scrapie NN cord-276616-odmnvv7m 97 8 show show NN cord-276616-odmnvv7m 97 9 points point NNS cord-276616-odmnvv7m 97 10 of of IN cord-276616-odmnvv7m 97 11 resemblance resemblance NN cord-276616-odmnvv7m 97 12 . . . cord-276616-odmnvv7m 98 1 In in IN cord-276616-odmnvv7m 98 2 scrapie scrapie NN cord-276616-odmnvv7m 98 3 , , , cord-276616-odmnvv7m 98 4 there there EX cord-276616-odmnvv7m 98 5 are be VBP cord-276616-odmnvv7m 98 6 also also RB cord-276616-odmnvv7m 98 7 signs sign NNS cord-276616-odmnvv7m 98 8 of of IN cord-276616-odmnvv7m 98 9 increased increase VBN cord-276616-odmnvv7m 98 10 skin skin NN cord-276616-odmnvv7m 98 11 reactions reaction NNS cord-276616-odmnvv7m 98 12 to to IN cord-276616-odmnvv7m 98 13 pressure pressure NN cord-276616-odmnvv7m 98 14 and and CC cord-276616-odmnvv7m 98 15 other other JJ cord-276616-odmnvv7m 98 16 stimuli stimulus NNS cord-276616-odmnvv7m 98 17 . . . cord-276616-odmnvv7m 99 1 There there EX cord-276616-odmnvv7m 99 2 is be VBZ cord-276616-odmnvv7m 99 3 a a DT cord-276616-odmnvv7m 99 4 characteristic characteristic NN cord-276616-odmnvv7m 99 5 ' ' `` cord-276616-odmnvv7m 99 6 nibbling nibble VBG cord-276616-odmnvv7m 99 7 ' ' '' cord-276616-odmnvv7m 99 8 reaction reaction NN cord-276616-odmnvv7m 99 9 and and CC cord-276616-odmnvv7m 99 10 a a DT cord-276616-odmnvv7m 99 11 pruritus pruritus NN cord-276616-odmnvv7m 99 12 manifested manifest VBN cord-276616-odmnvv7m 99 13 by by IN cord-276616-odmnvv7m 99 14 the the DT cord-276616-odmnvv7m 99 15 sheep sheep NN cord-276616-odmnvv7m 99 16 rubbing rub VBG cord-276616-odmnvv7m 99 17 , , , cord-276616-odmnvv7m 99 18 leading lead VBG cord-276616-odmnvv7m 99 19 to to IN cord-276616-odmnvv7m 99 20 loss loss NN cord-276616-odmnvv7m 99 21 of of IN cord-276616-odmnvv7m 99 22 wool wool NN cord-276616-odmnvv7m 99 23 over over IN cord-276616-odmnvv7m 99 24 the the DT cord-276616-odmnvv7m 99 25 rump rump NN cord-276616-odmnvv7m 99 26 , , , cord-276616-odmnvv7m 99 27 thighs thigh NNS cord-276616-odmnvv7m 99 28 and and CC cord-276616-odmnvv7m 99 29 tail tail NN cord-276616-odmnvv7m 99 30 base base NN cord-276616-odmnvv7m 99 31 . . . cord-276616-odmnvv7m 100 1 There there EX cord-276616-odmnvv7m 100 2 is be VBZ cord-276616-odmnvv7m 100 3 impairment impairment NN cord-276616-odmnvv7m 100 4 of of IN cord-276616-odmnvv7m 100 5 locomotion locomotion NN cord-276616-odmnvv7m 100 6 , , , cord-276616-odmnvv7m 100 7 starting start VBG cord-276616-odmnvv7m 100 8 with with IN cord-276616-odmnvv7m 100 9 problems problem NNS cord-276616-odmnvv7m 100 10 in in IN cord-276616-odmnvv7m 100 11 the the DT cord-276616-odmnvv7m 100 12 hind hind NN cord-276616-odmnvv7m 100 13 limbs limb NNS cord-276616-odmnvv7m 100 14 ( ( -LRB- cord-276616-odmnvv7m 100 15 Blood blood NN cord-276616-odmnvv7m 100 16 et et NNP cord-276616-odmnvv7m 100 17 al al NNP cord-276616-odmnvv7m 100 18 . . NNP cord-276616-odmnvv7m 100 19 , , , cord-276616-odmnvv7m 100 20 1983 1983 CD cord-276616-odmnvv7m 100 21 ) ) -RRB- cord-276616-odmnvv7m 100 22 . . . cord-276616-odmnvv7m 101 1 Although although IN cord-276616-odmnvv7m 101 2 scrapie scrapie NN cord-276616-odmnvv7m 101 3 is be VBZ cord-276616-odmnvv7m 101 4 a a DT cord-276616-odmnvv7m 101 5 far far RB cord-276616-odmnvv7m 101 6 more more RBR cord-276616-odmnvv7m 101 7 chronic chronic JJ cord-276616-odmnvv7m 101 8 disease disease NN cord-276616-odmnvv7m 101 9 than than IN cord-276616-odmnvv7m 101 10 louping louping NN cord-276616-odmnvv7m 101 11 - - HYPH cord-276616-odmnvv7m 101 12 ill ill JJ cord-276616-odmnvv7m 101 13 , , , cord-276616-odmnvv7m 101 14 it -PRON- PRP cord-276616-odmnvv7m 101 15 is be VBZ cord-276616-odmnvv7m 101 16 curious curious JJ cord-276616-odmnvv7m 101 17 that that IN cord-276616-odmnvv7m 101 18 variations variation NNS cord-276616-odmnvv7m 101 19 of of IN cord-276616-odmnvv7m 101 20 hyperaesthesia hyperaesthesia NNP cord-276616-odmnvv7m 101 21 are be VBP cord-276616-odmnvv7m 101 22 observed observe VBN cord-276616-odmnvv7m 101 23 in in IN cord-276616-odmnvv7m 101 24 both both PDT cord-276616-odmnvv7m 101 25 these these DT cord-276616-odmnvv7m 101 26 diseases disease NNS cord-276616-odmnvv7m 101 27 , , , cord-276616-odmnvv7m 101 28 with with IN cord-276616-odmnvv7m 101 29 very very RB cord-276616-odmnvv7m 101 30 different different JJ cord-276616-odmnvv7m 101 31 aetiologies aetiology NNS cord-276616-odmnvv7m 101 32 . . . cord-276616-odmnvv7m 102 1 In in IN cord-276616-odmnvv7m 102 2 bovine bovine JJ cord-276616-odmnvv7m 102 3 spongiform spongiform JJ cord-276616-odmnvv7m 102 4 encephalopathy encephalopathy NN cord-276616-odmnvv7m 102 5 ( ( -LRB- cord-276616-odmnvv7m 102 6 BSE BSE NNP cord-276616-odmnvv7m 102 7 ) ) -RRB- cord-276616-odmnvv7m 102 8 , , , cord-276616-odmnvv7m 102 9 hypersensitivity hypersensitivity NN cord-276616-odmnvv7m 102 10 to to TO cord-276616-odmnvv7m 102 11 touch touch VB cord-276616-odmnvv7m 102 12 and and CC cord-276616-odmnvv7m 102 13 sound sound NN cord-276616-odmnvv7m 102 14 are be VBP cord-276616-odmnvv7m 102 15 also also RB cord-276616-odmnvv7m 102 16 common common JJ cord-276616-odmnvv7m 102 17 signs sign NNS cord-276616-odmnvv7m 102 18 , , , cord-276616-odmnvv7m 102 19 but but CC cord-276616-odmnvv7m 102 20 there there EX cord-276616-odmnvv7m 102 21 are be VBP cord-276616-odmnvv7m 102 22 many many JJ cord-276616-odmnvv7m 102 23 other other JJ cord-276616-odmnvv7m 102 24 subtle subtle JJ cord-276616-odmnvv7m 102 25 changes change NNS cord-276616-odmnvv7m 102 26 in in IN cord-276616-odmnvv7m 102 27 behaviour behaviour NN cord-276616-odmnvv7m 102 28 . . . cord-276616-odmnvv7m 103 1 However however RB cord-276616-odmnvv7m 103 2 , , , cord-276616-odmnvv7m 103 3 cases case NNS cord-276616-odmnvv7m 103 4 of of IN cord-276616-odmnvv7m 103 5 disease disease NN cord-276616-odmnvv7m 103 6 with with IN cord-276616-odmnvv7m 103 7 these these DT cord-276616-odmnvv7m 103 8 very very JJ cord-276616-odmnvv7m 103 9 signs sign NNS cord-276616-odmnvv7m 103 10 , , , cord-276616-odmnvv7m 103 11 but but CC cord-276616-odmnvv7m 103 12 which which WDT cord-276616-odmnvv7m 103 13 are be VBP cord-276616-odmnvv7m 103 14 not not RB cord-276616-odmnvv7m 103 15 BSE BSE NNP cord-276616-odmnvv7m 103 16 in in IN cord-276616-odmnvv7m 103 17 terms term NNS cord-276616-odmnvv7m 103 18 of of IN cord-276616-odmnvv7m 103 19 their -PRON- PRP$ cord-276616-odmnvv7m 103 20 histopathology histopathology NN cord-276616-odmnvv7m 103 21 , , , cord-276616-odmnvv7m 103 22 can can MD cord-276616-odmnvv7m 103 23 occur occur VB cord-276616-odmnvv7m 103 24 in in IN cord-276616-odmnvv7m 103 25 cattle cattle NNS cord-276616-odmnvv7m 103 26 ( ( -LRB- cord-276616-odmnvv7m 103 27 Jeffrey Jeffrey NNP cord-276616-odmnvv7m 103 28 and and CC cord-276616-odmnvv7m 103 29 Wilesmith Wilesmith NNP cord-276616-odmnvv7m 103 30 , , , cord-276616-odmnvv7m 103 31 1992 1992 CD cord-276616-odmnvv7m 103 32 ) ) -RRB- cord-276616-odmnvv7m 103 33 . . . cord-276616-odmnvv7m 104 1 It -PRON- PRP cord-276616-odmnvv7m 104 2 has have VBZ cord-276616-odmnvv7m 104 3 also also RB cord-276616-odmnvv7m 104 4 been be VBN cord-276616-odmnvv7m 104 5 suggested suggest VBN cord-276616-odmnvv7m 104 6 ( ( -LRB- cord-276616-odmnvv7m 104 7 Gibbs Gibbs NNP cord-276616-odmnvv7m 104 8 et et NNP cord-276616-odmnvv7m 104 9 aL aL NNP cord-276616-odmnvv7m 104 10 , , , cord-276616-odmnvv7m 104 11 1990 1990 CD cord-276616-odmnvv7m 104 12 ) ) -RRB- cord-276616-odmnvv7m 104 13 that that IN cord-276616-odmnvv7m 104 14 BSE BSE NNP cord-276616-odmnvv7m 104 15 may may MD cord-276616-odmnvv7m 104 16 have have VB cord-276616-odmnvv7m 104 17 occurred occur VBN cord-276616-odmnvv7m 104 18 in in IN cord-276616-odmnvv7m 104 19 the the DT cord-276616-odmnvv7m 104 20 United United NNP cord-276616-odmnvv7m 104 21 States States NNP cord-276616-odmnvv7m 104 22 under under IN cord-276616-odmnvv7m 104 23 the the DT cord-276616-odmnvv7m 104 24 clinical clinical JJ cord-276616-odmnvv7m 104 25 guise guise NN cord-276616-odmnvv7m 104 26 of of IN cord-276616-odmnvv7m 104 27 the the DT cord-276616-odmnvv7m 104 28 ' ' `` cord-276616-odmnvv7m 104 29 downer downer NNP cord-276616-odmnvv7m 104 30 cow cow NN cord-276616-odmnvv7m 104 31 ' ' '' cord-276616-odmnvv7m 104 32 syndrome syndrome NN cord-276616-odmnvv7m 104 33 , , , cord-276616-odmnvv7m 104 34 even even RB cord-276616-odmnvv7m 104 35 though though IN cord-276616-odmnvv7m 104 36 cattle cattle NNS cord-276616-odmnvv7m 104 37 disease disease NN cord-276616-odmnvv7m 104 38 due due JJ cord-276616-odmnvv7m 104 39 to to IN cord-276616-odmnvv7m 104 40 BSE BSE NNP cord-276616-odmnvv7m 104 41 has have VBZ cord-276616-odmnvv7m 104 42 not not RB cord-276616-odmnvv7m 104 43 been be VBN cord-276616-odmnvv7m 104 44 reported report VBN cord-276616-odmnvv7m 104 45 in in IN cord-276616-odmnvv7m 104 46 that that DT cord-276616-odmnvv7m 104 47 country country NN cord-276616-odmnvv7m 104 48 . . . cord-276616-odmnvv7m 105 1 These these DT cord-276616-odmnvv7m 105 2 workers worker NNS cord-276616-odmnvv7m 105 3 attempted attempt VBD cord-276616-odmnvv7m 105 4 experimental experimental JJ cord-276616-odmnvv7m 105 5 transmission transmission NN cord-276616-odmnvv7m 105 6 of of IN cord-276616-odmnvv7m 105 7 the the DT cord-276616-odmnvv7m 105 8 scrapie scrapie NN cord-276616-odmnvv7m 105 9 agent agent NN cord-276616-odmnvv7m 105 10 in in IN cord-276616-odmnvv7m 105 11 brain brain NN cord-276616-odmnvv7m 105 12 homogenate homogenate NNP cord-276616-odmnvv7m 105 13 from from IN cord-276616-odmnvv7m 105 14 sheep sheep NNS cord-276616-odmnvv7m 105 15 or or CC cord-276616-odmnvv7m 105 16 goats goat NNS cord-276616-odmnvv7m 105 17 to to IN cord-276616-odmnvv7m 105 18 10 10 CD cord-276616-odmnvv7m 105 19 cattle cattle NNS cord-276616-odmnvv7m 105 20 . . . cord-276616-odmnvv7m 106 1 Three three CD cord-276616-odmnvv7m 106 2 cattle cattle NNS cord-276616-odmnvv7m 106 3 developed develop VBD cord-276616-odmnvv7m 106 4 neurological neurological JJ cord-276616-odmnvv7m 106 5 signs sign NNS cord-276616-odmnvv7m 106 6 27 27 CD cord-276616-odmnvv7m 106 7 - - SYM cord-276616-odmnvv7m 106 8 48 48 CD cord-276616-odmnvv7m 106 9 months month NNS cord-276616-odmnvv7m 106 10 after after IN cord-276616-odmnvv7m 106 11 inoculation inoculation NN cord-276616-odmnvv7m 106 12 , , , cord-276616-odmnvv7m 106 13 consisting consist VBG cord-276616-odmnvv7m 106 14 of of IN cord-276616-odmnvv7m 106 15 progressive progressive JJ cord-276616-odmnvv7m 106 16 difficulty difficulty NN cord-276616-odmnvv7m 106 17 in in IN cord-276616-odmnvv7m 106 18 rising rise VBG cord-276616-odmnvv7m 106 19 , , , cord-276616-odmnvv7m 106 20 stiff stiff JJ cord-276616-odmnvv7m 106 21 - - HYPH cord-276616-odmnvv7m 106 22 legged legged JJ cord-276616-odmnvv7m 106 23 stilted stilted JJ cord-276616-odmnvv7m 106 24 gait gait NN cord-276616-odmnvv7m 106 25 , , , cord-276616-odmnvv7m 106 26 incoordination incoordination NN cord-276616-odmnvv7m 106 27 , , , cord-276616-odmnvv7m 106 28 disorientation disorientation NN cord-276616-odmnvv7m 106 29 and and CC cord-276616-odmnvv7m 106 30 terminal terminal JJ cord-276616-odmnvv7m 106 31 recumbency recumbency NN cord-276616-odmnvv7m 106 32 . . . cord-276616-odmnvv7m 107 1 From from IN cord-276616-odmnvv7m 107 2 onset onset NN cord-276616-odmnvv7m 107 3 to to IN cord-276616-odmnvv7m 107 4 terminal terminal JJ cord-276616-odmnvv7m 107 5 signs sign NNS cord-276616-odmnvv7m 107 6 , , , cord-276616-odmnvv7m 107 7 the the DT cord-276616-odmnvv7m 107 8 disease disease NN cord-276616-odmnvv7m 107 9 lasted last VBD cord-276616-odmnvv7m 107 10 1 1 CD cord-276616-odmnvv7m 107 11 - - SYM cord-276616-odmnvv7m 107 12 2.5 2.5 CD cord-276616-odmnvv7m 107 13 months month NNS cord-276616-odmnvv7m 107 14 . . . cord-276616-odmnvv7m 108 1 There there EX cord-276616-odmnvv7m 108 2 were be VBD cord-276616-odmnvv7m 108 3 resemblances resemblance NNS cord-276616-odmnvv7m 108 4 to to IN cord-276616-odmnvv7m 108 5 the the DT cord-276616-odmnvv7m 108 6 ' ' `` cord-276616-odmnvv7m 108 7 downer downer JJ cord-276616-odmnvv7m 108 8 cow cow NN cord-276616-odmnvv7m 108 9 ' ' '' cord-276616-odmnvv7m 108 10 syndrome syndrome NN cord-276616-odmnvv7m 108 11 . . . cord-276616-odmnvv7m 109 1 While while IN cord-276616-odmnvv7m 109 2 autopsy autopsy JJ cord-276616-odmnvv7m 109 3 revealed reveal VBD cord-276616-odmnvv7m 109 4 insufficient insufficient JJ cord-276616-odmnvv7m 109 5 changes change NNS cord-276616-odmnvv7m 109 6 to to TO cord-276616-odmnvv7m 109 7 confirm confirm VB cord-276616-odmnvv7m 109 8 a a DT cord-276616-odmnvv7m 109 9 clinical clinical JJ cord-276616-odmnvv7m 109 10 diagnosis diagnosis NN cord-276616-odmnvv7m 109 11 of of IN cord-276616-odmnvv7m 109 12 BSE BSE NNP cord-276616-odmnvv7m 109 13 , , , cord-276616-odmnvv7m 109 14 the the DT cord-276616-odmnvv7m 109 15 protease protease NN cord-276616-odmnvv7m 109 16 - - HYPH cord-276616-odmnvv7m 109 17 resistant resistant JJ cord-276616-odmnvv7m 109 18 protein protein NN cord-276616-odmnvv7m 109 19 PrP27 PrP27 NNS cord-276616-odmnvv7m 109 20 - - HYPH cord-276616-odmnvv7m 109 21 30 30 CD cord-276616-odmnvv7m 109 22 was be VBD cord-276616-odmnvv7m 109 23 detected detect VBN cord-276616-odmnvv7m 109 24 in in IN cord-276616-odmnvv7m 109 25 each each DT cord-276616-odmnvv7m 109 26 of of IN cord-276616-odmnvv7m 109 27 the the DT cord-276616-odmnvv7m 109 28 3 3 CD cord-276616-odmnvv7m 109 29 animals animal NNS cord-276616-odmnvv7m 109 30 with with IN cord-276616-odmnvv7m 109 31 neurological neurological JJ cord-276616-odmnvv7m 109 32 signs sign NNS cord-276616-odmnvv7m 109 33 ; ; : cord-276616-odmnvv7m 109 34 none none NN cord-276616-odmnvv7m 109 35 was be VBD cord-276616-odmnvv7m 109 36 detected detect VBN cord-276616-odmnvv7m 109 37 in in IN cord-276616-odmnvv7m 109 38 the the DT cord-276616-odmnvv7m 109 39 other other JJ cord-276616-odmnvv7m 109 40 7 7 CD cord-276616-odmnvv7m 109 41 animals animal NNS cord-276616-odmnvv7m 109 42 . . . cord-276616-odmnvv7m 110 1 If if IN cord-276616-odmnvv7m 110 2 the the DT cord-276616-odmnvv7m 110 3 results result NNS cord-276616-odmnvv7m 110 4 of of IN cord-276616-odmnvv7m 110 5 this this DT cord-276616-odmnvv7m 110 6 experiment experiment NN cord-276616-odmnvv7m 110 7 can can MD cord-276616-odmnvv7m 110 8 be be VB cord-276616-odmnvv7m 110 9 replicated replicate VBN cord-276616-odmnvv7m 110 10 , , , cord-276616-odmnvv7m 110 11 the the DT cord-276616-odmnvv7m 110 12 consequences consequence NNS cord-276616-odmnvv7m 110 13 are be VBP cord-276616-odmnvv7m 110 14 serious serious JJ cord-276616-odmnvv7m 110 15 . . . cord-276616-odmnvv7m 111 1 The the DT cord-276616-odmnvv7m 111 2 ' ' `` cord-276616-odmnvv7m 111 3 downer downer JJ cord-276616-odmnvv7m 111 4 cow cow NN cord-276616-odmnvv7m 111 5 ' ' '' cord-276616-odmnvv7m 111 6 is be VBZ cord-276616-odmnvv7m 111 7 a a DT cord-276616-odmnvv7m 111 8 familiar familiar JJ cord-276616-odmnvv7m 111 9 one one CD cord-276616-odmnvv7m 111 10 to to IN cord-276616-odmnvv7m 111 11 veterinarians veterinarian NNS cord-276616-odmnvv7m 111 12 and and CC cord-276616-odmnvv7m 111 13 , , , cord-276616-odmnvv7m 111 14 while while IN cord-276616-odmnvv7m 111 15 the the DT cord-276616-odmnvv7m 111 16 usual usual JJ cord-276616-odmnvv7m 111 17 aetiology aetiology NN cord-276616-odmnvv7m 111 18 is be VBZ cord-276616-odmnvv7m 111 19 a a DT cord-276616-odmnvv7m 111 20 Ca Ca NNP cord-276616-odmnvv7m 111 21 / / SYM cord-276616-odmnvv7m 111 22 P p NN cord-276616-odmnvv7m 111 23 imbalance imbalance NN cord-276616-odmnvv7m 111 24 , , , cord-276616-odmnvv7m 111 25 successful successful JJ cord-276616-odmnvv7m 111 26 repetition repetition NN cord-276616-odmnvv7m 111 27 of of IN cord-276616-odmnvv7m 111 28 this this DT cord-276616-odmnvv7m 111 29 experiment experiment NN cord-276616-odmnvv7m 111 30 would would MD cord-276616-odmnvv7m 111 31 mean mean VB cord-276616-odmnvv7m 111 32 that that DT cord-276616-odmnvv7m 111 33 , , , cord-276616-odmnvv7m 111 34 where where WRB cord-276616-odmnvv7m 111 35 that that DT cord-276616-odmnvv7m 111 36 imbalance imbalance NN cord-276616-odmnvv7m 111 37 can can MD cord-276616-odmnvv7m 111 38 not not RB cord-276616-odmnvv7m 111 39 be be VB cord-276616-odmnvv7m 111 40 demonstrated demonstrate VBN cord-276616-odmnvv7m 111 41 , , , cord-276616-odmnvv7m 111 42 the the DT cord-276616-odmnvv7m 111 43 presence presence NN cord-276616-odmnvv7m 111 44 or or CC cord-276616-odmnvv7m 111 45 absence absence NN cord-276616-odmnvv7m 111 46 of of IN cord-276616-odmnvv7m 111 47 BSE BSE NNP cord-276616-odmnvv7m 111 48 will will MD cord-276616-odmnvv7m 111 49 have have VB cord-276616-odmnvv7m 111 50 to to TO cord-276616-odmnvv7m 111 51 be be VB cord-276616-odmnvv7m 111 52 verified verify VBN cord-276616-odmnvv7m 111 53 . . . cord-276616-odmnvv7m 112 1 The the DT cord-276616-odmnvv7m 112 2 signs sign NNS cord-276616-odmnvv7m 112 3 and and CC cord-276616-odmnvv7m 112 4 symptoms symptom NNS cord-276616-odmnvv7m 112 5 that that WDT cord-276616-odmnvv7m 112 6 follow follow VBP cord-276616-odmnvv7m 112 7 the the DT cord-276616-odmnvv7m 112 8 onset onset NN cord-276616-odmnvv7m 112 9 of of IN cord-276616-odmnvv7m 112 10 the the DT cord-276616-odmnvv7m 112 11 human human JJ cord-276616-odmnvv7m 112 12 spongiform spongiform NNP cord-276616-odmnvv7m 112 13 encephalopathies encephalopathy NNS cord-276616-odmnvv7m 112 14 show show VBP cord-276616-odmnvv7m 112 15 some some DT cord-276616-odmnvv7m 112 16 differences difference NNS cord-276616-odmnvv7m 112 17 between between IN cord-276616-odmnvv7m 112 18 types type NNS cord-276616-odmnvv7m 112 19 : : : cord-276616-odmnvv7m 112 20 in in IN cord-276616-odmnvv7m 112 21 Kuru Kuru NNP cord-276616-odmnvv7m 112 22 there there EX cord-276616-odmnvv7m 112 23 is be VBZ cord-276616-odmnvv7m 112 24 a a DT cord-276616-odmnvv7m 112 25 fine fine JJ cord-276616-odmnvv7m 112 26 tremor tremor NN cord-276616-odmnvv7m 112 27 of of IN cord-276616-odmnvv7m 112 28 the the DT cord-276616-odmnvv7m 112 29 head head NN cord-276616-odmnvv7m 112 30 , , , cord-276616-odmnvv7m 112 31 trunk trunk NN cord-276616-odmnvv7m 112 32 and and CC cord-276616-odmnvv7m 112 33 limbs limb NNS cord-276616-odmnvv7m 112 34 , , , cord-276616-odmnvv7m 112 35 together together RB cord-276616-odmnvv7m 112 36 with with IN cord-276616-odmnvv7m 112 37 the the DT cord-276616-odmnvv7m 112 38 onset onset NN cord-276616-odmnvv7m 112 39 of of IN cord-276616-odmnvv7m 112 40 a a DT cord-276616-odmnvv7m 112 41 progressive progressive JJ cord-276616-odmnvv7m 112 42 ataxia ataxia NN cord-276616-odmnvv7m 112 43 ; ; : cord-276616-odmnvv7m 112 44 in in IN cord-276616-odmnvv7m 112 45 CJD CJD NNP cord-276616-odmnvv7m 112 46 the the DT cord-276616-odmnvv7m 112 47 symptoms symptom NNS cord-276616-odmnvv7m 112 48 are be VBP cord-276616-odmnvv7m 112 49 of of IN cord-276616-odmnvv7m 112 50 dementia dementia NN cord-276616-odmnvv7m 112 51 and and CC cord-276616-odmnvv7m 112 52 , , , cord-276616-odmnvv7m 112 53 instead instead RB cord-276616-odmnvv7m 112 54 of of IN cord-276616-odmnvv7m 112 55 the the DT cord-276616-odmnvv7m 112 56 fine fine JJ cord-276616-odmnvv7m 112 57 tremor tremor NN cord-276616-odmnvv7m 112 58 , , , cord-276616-odmnvv7m 112 59 there there EX cord-276616-odmnvv7m 112 60 is be VBZ cord-276616-odmnvv7m 112 61 a a DT cord-276616-odmnvv7m 112 62 myoclonic myoclonic JJ cord-276616-odmnvv7m 112 63 jerking jerking NN cord-276616-odmnvv7m 112 64 ; ; : cord-276616-odmnvv7m 112 65 in in IN cord-276616-odmnvv7m 112 66 GSSD GSSD NNP cord-276616-odmnvv7m 112 67 there there EX cord-276616-odmnvv7m 112 68 is be VBZ cord-276616-odmnvv7m 112 69 an an DT cord-276616-odmnvv7m 112 70 overlap overlap NN cord-276616-odmnvv7m 112 71 with with IN cord-276616-odmnvv7m 112 72 the the DT cord-276616-odmnvv7m 112 73 signs sign NNS cord-276616-odmnvv7m 112 74 of of IN cord-276616-odmnvv7m 112 75 Kuru Kuru NNP cord-276616-odmnvv7m 112 76 and and CC cord-276616-odmnvv7m 112 77 CJD CJD NNP cord-276616-odmnvv7m 112 78 and and CC cord-276616-odmnvv7m 112 79 there there EX cord-276616-odmnvv7m 112 80 is be VBZ cord-276616-odmnvv7m 112 81 also also RB cord-276616-odmnvv7m 112 82 a a DT cord-276616-odmnvv7m 112 83 marked mark VBN cord-276616-odmnvv7m 112 84 dementia dementia NN cord-276616-odmnvv7m 112 85 . . . cord-276616-odmnvv7m 113 1 The the DT cord-276616-odmnvv7m 113 2 type type NN cord-276616-odmnvv7m 113 3 of of IN cord-276616-odmnvv7m 113 4 hypersensitivity hypersensitivity NN cord-276616-odmnvv7m 113 5 associated associate VBN cord-276616-odmnvv7m 113 6 with with IN cord-276616-odmnvv7m 113 7 scrapie scrapie NN cord-276616-odmnvv7m 113 8 and and CC cord-276616-odmnvv7m 113 9 BSE BSE NNP cord-276616-odmnvv7m 113 10 is be VBZ cord-276616-odmnvv7m 113 11 absent absent JJ cord-276616-odmnvv7m 113 12 . . . cord-276616-odmnvv7m 114 1 Returning return VBG cord-276616-odmnvv7m 114 2 to to IN cord-276616-odmnvv7m 114 3 the the DT cord-276616-odmnvv7m 114 4 pruritus pruritus NN cord-276616-odmnvv7m 114 5 seen see VBN cord-276616-odmnvv7m 114 6 in in IN cord-276616-odmnvv7m 114 7 scrapie scrapie NN cord-276616-odmnvv7m 114 8 and and CC cord-276616-odmnvv7m 114 9 BSE BSE NNP cord-276616-odmnvv7m 114 10 , , , cord-276616-odmnvv7m 114 11 there there EX cord-276616-odmnvv7m 114 12 seems seem VBZ cord-276616-odmnvv7m 114 13 to to TO cord-276616-odmnvv7m 114 14 have have VB cord-276616-odmnvv7m 114 15 been be VBN cord-276616-odmnvv7m 114 16 no no DT cord-276616-odmnvv7m 114 17 investigation investigation NN cord-276616-odmnvv7m 114 18 of of IN cord-276616-odmnvv7m 114 19 the the DT cord-276616-odmnvv7m 114 20 cause cause NN cord-276616-odmnvv7m 114 21 of of IN cord-276616-odmnvv7m 114 22 the the DT cord-276616-odmnvv7m 114 23 irritation irritation NN cord-276616-odmnvv7m 114 24 . . . cord-276616-odmnvv7m 115 1 One one PRP cord-276616-odmnvv7m 115 2 must must MD cord-276616-odmnvv7m 115 3 question question VB cord-276616-odmnvv7m 115 4 whether whether IN cord-276616-odmnvv7m 115 5 the the DT cord-276616-odmnvv7m 115 6 hyperaesthesia hyperaesthesia NNP cord-276616-odmnvv7m 115 7 is be VBZ cord-276616-odmnvv7m 115 8 evidence evidence NN cord-276616-odmnvv7m 115 9 solely solely RB cord-276616-odmnvv7m 115 10 of of IN cord-276616-odmnvv7m 115 11 nerve nerve JJ cord-276616-odmnvv7m 115 12 irritation irritation NN cord-276616-odmnvv7m 115 13 or or CC cord-276616-odmnvv7m 115 14 whether whether IN cord-276616-odmnvv7m 115 15 it -PRON- PRP cord-276616-odmnvv7m 115 16 is be VBZ cord-276616-odmnvv7m 115 17 a a DT cord-276616-odmnvv7m 115 18 pointer pointer NN cord-276616-odmnvv7m 115 19 to to IN cord-276616-odmnvv7m 115 20 a a DT cord-276616-odmnvv7m 115 21 development development NN cord-276616-odmnvv7m 115 22 of of IN cord-276616-odmnvv7m 115 23 the the DT cord-276616-odmnvv7m 115 24 hypersensitivity hypersensitivity NN cord-276616-odmnvv7m 115 25 or or CC cord-276616-odmnvv7m 115 26 skin skin NN cord-276616-odmnvv7m 115 27 lesions lesion NNS cord-276616-odmnvv7m 115 28 seen see VBN cord-276616-odmnvv7m 115 29 in in IN cord-276616-odmnvv7m 115 30 some some DT cord-276616-odmnvv7m 115 31 virus virus NN cord-276616-odmnvv7m 115 32 infections infection NNS cord-276616-odmnvv7m 115 33 ( ( -LRB- cord-276616-odmnvv7m 115 34 Fenner Fenner NNP cord-276616-odmnvv7m 115 35 et et NNP cord-276616-odmnvv7m 115 36 al al NNP cord-276616-odmnvv7m 115 37 . . NNP cord-276616-odmnvv7m 115 38 , , , cord-276616-odmnvv7m 115 39 1974 1974 CD cord-276616-odmnvv7m 115 40 ) ) -RRB- cord-276616-odmnvv7m 115 41 or or CC cord-276616-odmnvv7m 115 42 even even RB cord-276616-odmnvv7m 115 43 related related JJ cord-276616-odmnvv7m 115 44 to to IN cord-276616-odmnvv7m 115 45 the the DT cord-276616-odmnvv7m 115 46 local local JJ cord-276616-odmnvv7m 115 47 release release NN cord-276616-odmnvv7m 115 48 of of IN cord-276616-odmnvv7m 115 49 histamine histamine NN cord-276616-odmnvv7m 115 50 or or CC cord-276616-odmnvv7m 115 51 a a DT cord-276616-odmnvv7m 115 52 related related JJ cord-276616-odmnvv7m 115 53 compound compound NN cord-276616-odmnvv7m 115 54 . . . cord-276616-odmnvv7m 116 1 There there EX cord-276616-odmnvv7m 116 2 are be VBP cord-276616-odmnvv7m 116 3 no no DT cord-276616-odmnvv7m 116 4 immunological immunological JJ cord-276616-odmnvv7m 116 5 tests test NNS cord-276616-odmnvv7m 116 6 to to TO cord-276616-odmnvv7m 116 7 aid aid VB cord-276616-odmnvv7m 116 8 recognition recognition NN cord-276616-odmnvv7m 116 9 of of IN cord-276616-odmnvv7m 116 10 the the DT cord-276616-odmnvv7m 116 11 diseased diseased JJ cord-276616-odmnvv7m 116 12 living living NN cord-276616-odmnvv7m 116 13 animal animal NN cord-276616-odmnvv7m 116 14 . . . cord-276616-odmnvv7m 117 1 Clinical clinical JJ cord-276616-odmnvv7m 117 2 signs sign NNS cord-276616-odmnvv7m 117 3 are be VBP cord-276616-odmnvv7m 117 4 not not RB cord-276616-odmnvv7m 117 5 sufficiently sufficiently RB cord-276616-odmnvv7m 117 6 specific specific JJ cord-276616-odmnvv7m 117 7 to to TO cord-276616-odmnvv7m 117 8 diagnose diagnose VB cord-276616-odmnvv7m 117 9 disease disease NN cord-276616-odmnvv7m 117 10 and and CC cord-276616-odmnvv7m 117 11 diagnosis diagnosis NN cord-276616-odmnvv7m 117 12 depends depend VBZ cord-276616-odmnvv7m 117 13 on on IN cord-276616-odmnvv7m 117 14 the the DT cord-276616-odmnvv7m 117 15 examination examination NN cord-276616-odmnvv7m 117 16 , , , cord-276616-odmnvv7m 117 17 by by IN cord-276616-odmnvv7m 117 18 experienced experienced JJ cord-276616-odmnvv7m 117 19 pathologists pathologist NNS cord-276616-odmnvv7m 117 20 , , , cord-276616-odmnvv7m 117 21 of of IN cord-276616-odmnvv7m 117 22 stained stained JJ cord-276616-odmnvv7m 117 23 sections section NNS cord-276616-odmnvv7m 117 24 of of IN cord-276616-odmnvv7m 117 25 brain brain NN cord-276616-odmnvv7m 117 26 tissue tissue NN cord-276616-odmnvv7m 117 27 for for IN cord-276616-odmnvv7m 117 28 characteristic characteristic JJ cord-276616-odmnvv7m 117 29 lesions lesion NNS cord-276616-odmnvv7m 117 30 ( ( -LRB- cord-276616-odmnvv7m 117 31 Wells Wells NNP cord-276616-odmnvv7m 117 32 and and CC cord-276616-odmnvv7m 117 33 McGiU McGiU NNPS cord-276616-odmnvv7m 117 34 , , , cord-276616-odmnvv7m 117 35 1990 1990 CD cord-276616-odmnvv7m 117 36 ) ) -RRB- cord-276616-odmnvv7m 117 37 , , , cord-276616-odmnvv7m 117 38 electron electron NN cord-276616-odmnvv7m 117 39 microscopy microscopy NN cord-276616-odmnvv7m 117 40 to to TO cord-276616-odmnvv7m 117 41 detect detect VB cord-276616-odmnvv7m 117 42 the the DT cord-276616-odmnvv7m 117 43 characteristic characteristic JJ cord-276616-odmnvv7m 117 44 SAF SAF NNP cord-276616-odmnvv7m 117 45 fibrils fibril NNS cord-276616-odmnvv7m 117 46 ) ) -RRB- cord-276616-odmnvv7m 117 47 and and CC cord-276616-odmnvv7m 117 48 tests test NNS cord-276616-odmnvv7m 117 49 to to TO cord-276616-odmnvv7m 117 50 detect detect VB cord-276616-odmnvv7m 117 51 PrPSc PrPSc NNP cord-276616-odmnvv7m 117 52 , , , cord-276616-odmnvv7m 117 53 the the DT cord-276616-odmnvv7m 117 54 prion prion NN cord-276616-odmnvv7m 117 55 protein protein NN cord-276616-odmnvv7m 117 56 characteristically characteristically RB cord-276616-odmnvv7m 117 57 found find VBN cord-276616-odmnvv7m 117 58 in in IN cord-276616-odmnvv7m 117 59 the the DT cord-276616-odmnvv7m 117 60 spongiform spongiform JJ cord-276616-odmnvv7m 117 61 encephalopathies encephalopathy NNS cord-276616-odmnvv7m 117 62 ( ( -LRB- cord-276616-odmnvv7m 117 63 Cho Cho NNP cord-276616-odmnvv7m 117 64 , , , cord-276616-odmnvv7m 117 65 1986 1986 CD cord-276616-odmnvv7m 117 66 ; ; : cord-276616-odmnvv7m 117 67 Rubenstein Rubenstein NNP cord-276616-odmnvv7m 117 68 et et NNP cord-276616-odmnvv7m 117 69 aL aL NNP cord-276616-odmnvv7m 117 70 , , , cord-276616-odmnvv7m 117 71 1986 1986 CD cord-276616-odmnvv7m 117 72 ) ) -RRB- cord-276616-odmnvv7m 117 73 . . . cord-276616-odmnvv7m 118 1 This this DT cord-276616-odmnvv7m 118 2 latter latter JJ cord-276616-odmnvv7m 118 3 protein protein NN cord-276616-odmnvv7m 118 4 is be VBZ cord-276616-odmnvv7m 118 5 characteristically characteristically RB cord-276616-odmnvv7m 118 6 resistant resistant JJ cord-276616-odmnvv7m 118 7 to to IN cord-276616-odmnvv7m 119 1 proteinase proteinase NN cord-276616-odmnvv7m 119 2 - - HYPH cord-276616-odmnvv7m 119 3 K. K. NNP cord-276616-odmnvv7m 119 4 PrPSc PrPSc NNP cord-276616-odmnvv7m 119 5 contributes contribute VBZ cord-276616-odmnvv7m 119 6 to to IN cord-276616-odmnvv7m 119 7 the the DT cord-276616-odmnvv7m 119 8 formation formation NN cord-276616-odmnvv7m 119 9 of of IN cord-276616-odmnvv7m 119 10 the the DT cord-276616-odmnvv7m 119 11 amyloid amyloid NN cord-276616-odmnvv7m 119 12 aggregates aggregate NNS cord-276616-odmnvv7m 119 13 or or CC cord-276616-odmnvv7m 119 14 plaques plaque NNS cord-276616-odmnvv7m 119 15 seen see VBN cord-276616-odmnvv7m 119 16 in in IN cord-276616-odmnvv7m 119 17 the the DT cord-276616-odmnvv7m 119 18 brain brain NN cord-276616-odmnvv7m 119 19 of of IN cord-276616-odmnvv7m 119 20 animals animal NNS cord-276616-odmnvv7m 119 21 with with IN cord-276616-odmnvv7m 119 22 scrapie scrapie NN cord-276616-odmnvv7m 119 23 . . . cord-276616-odmnvv7m 120 1 PrPSc PrPSc NNP cord-276616-odmnvv7m 120 2 is be VBZ cord-276616-odmnvv7m 120 3 encoded encode VBN cord-276616-odmnvv7m 120 4 by by IN cord-276616-odmnvv7m 120 5 the the DT cord-276616-odmnvv7m 120 6 PrP prp NN cord-276616-odmnvv7m 120 7 gene gene NN cord-276616-odmnvv7m 120 8 , , , cord-276616-odmnvv7m 120 9 which which WDT cord-276616-odmnvv7m 120 10 expresses express VBZ cord-276616-odmnvv7m 120 11 a a DT cord-276616-odmnvv7m 120 12 similar similar JJ cord-276616-odmnvv7m 120 13 protein protein NN cord-276616-odmnvv7m 120 14 PrP prp NN cord-276616-odmnvv7m 120 15 - - HYPH cord-276616-odmnvv7m 120 16 C C NNP cord-276616-odmnvv7m 120 17 ( ( -LRB- cord-276616-odmnvv7m 120 18 sensitive sensitive JJ cord-276616-odmnvv7m 120 19 to to IN cord-276616-odmnvv7m 120 20 the the DT cord-276616-odmnvv7m 120 21 action action NN cord-276616-odmnvv7m 120 22 of of IN cord-276616-odmnvv7m 120 23 proteinase proteinase NN cord-276616-odmnvv7m 120 24 - - HYPH cord-276616-odmnvv7m 120 25 K k NN cord-276616-odmnvv7m 120 26 ) ) -RRB- cord-276616-odmnvv7m 120 27 in in IN cord-276616-odmnvv7m 120 28 uninfected uninfected JJ cord-276616-odmnvv7m 120 29 tissues tissue NNS cord-276616-odmnvv7m 120 30 . . . cord-276616-odmnvv7m 121 1 In in IN cord-276616-odmnvv7m 121 2 the the DT cord-276616-odmnvv7m 121 3 past past NN cord-276616-odmnvv7m 121 4 , , , cord-276616-odmnvv7m 121 5 one one CD cord-276616-odmnvv7m 121 6 histological histological JJ cord-276616-odmnvv7m 121 7 characteristic characteristic NN cord-276616-odmnvv7m 121 8 of of IN cord-276616-odmnvv7m 121 9 the the DT cord-276616-odmnvv7m 121 10 brain brain NN cord-276616-odmnvv7m 121 11 lesions lesion NNS cord-276616-odmnvv7m 121 12 seen see VBN cord-276616-odmnvv7m 121 13 in in IN cord-276616-odmnvv7m 121 14 spongiform spongiform JJ cord-276616-odmnvv7m 121 15 encephalopathies encephalopathy NNS cord-276616-odmnvv7m 121 16 drew draw VBD cord-276616-odmnvv7m 121 17 much much JJ cord-276616-odmnvv7m 121 18 interest interest NN cord-276616-odmnvv7m 121 19 , , , cord-276616-odmnvv7m 121 20 this this DT cord-276616-odmnvv7m 121 21 being be VBG cord-276616-odmnvv7m 121 22 the the DT cord-276616-odmnvv7m 121 23 occurrence occurrence NN cord-276616-odmnvv7m 121 24 of of IN cord-276616-odmnvv7m 121 25 large large JJ cord-276616-odmnvv7m 121 26 vacuoles vacuole NNS cord-276616-odmnvv7m 121 27 outside outside IN cord-276616-odmnvv7m 121 28 the the DT cord-276616-odmnvv7m 121 29 outer outer JJ cord-276616-odmnvv7m 121 30 wall wall NN cord-276616-odmnvv7m 121 31 of of IN cord-276616-odmnvv7m 121 32 neurons neuron NNS cord-276616-odmnvv7m 121 33 . . . cord-276616-odmnvv7m 122 1 No no DT cord-276616-odmnvv7m 122 2 good good JJ cord-276616-odmnvv7m 122 3 explanation explanation NN cord-276616-odmnvv7m 122 4 has have VBZ cord-276616-odmnvv7m 122 5 yet yet RB cord-276616-odmnvv7m 122 6 been be VBN cord-276616-odmnvv7m 122 7 found find VBN cord-276616-odmnvv7m 122 8 for for IN cord-276616-odmnvv7m 122 9 these these DT cord-276616-odmnvv7m 122 10 vacuoles vacuole NNS cord-276616-odmnvv7m 122 11 , , , cord-276616-odmnvv7m 122 12 which which WDT cord-276616-odmnvv7m 122 13 invariably invariably RB cord-276616-odmnvv7m 122 14 appeared appear VBD cord-276616-odmnvv7m 122 15 empty empty JJ cord-276616-odmnvv7m 122 16 by by IN cord-276616-odmnvv7m 122 17 both both DT cord-276616-odmnvv7m 122 18 fight fight NN cord-276616-odmnvv7m 122 19 and and CC cord-276616-odmnvv7m 122 20 electron electron NN cord-276616-odmnvv7m 122 21 microscopy microscopy JJ cord-276616-odmnvv7m 122 22 -the -the WDT cord-276616-odmnvv7m 122 23 larger large JJR cord-276616-odmnvv7m 122 24 vacuoles vacuole NNS cord-276616-odmnvv7m 122 25 appearing appear VBG cord-276616-odmnvv7m 122 26 to to TO cord-276616-odmnvv7m 122 27 have have VB cord-276616-odmnvv7m 122 28 formed form VBN cord-276616-odmnvv7m 122 29 by by IN cord-276616-odmnvv7m 122 30 a a DT cord-276616-odmnvv7m 122 31 coalescence coalescence NN cord-276616-odmnvv7m 122 32 of of IN cord-276616-odmnvv7m 122 33 smaller small JJR cord-276616-odmnvv7m 122 34 vacuoles vacuole NNS cord-276616-odmnvv7m 122 35 . . . cord-276616-odmnvv7m 123 1 Although although IN cord-276616-odmnvv7m 123 2 interesting interesting JJ cord-276616-odmnvv7m 123 3 , , , cord-276616-odmnvv7m 123 4 these these DT cord-276616-odmnvv7m 123 5 vacuoles vacuole NNS cord-276616-odmnvv7m 123 6 are be VBP cord-276616-odmnvv7m 123 7 not not RB cord-276616-odmnvv7m 123 8 pathognomonic pathognomonic JJ cord-276616-odmnvv7m 123 9 , , , cord-276616-odmnvv7m 123 10 as as IN cord-276616-odmnvv7m 123 11 similar similar JJ cord-276616-odmnvv7m 123 12 vacuolation vacuolation NN cord-276616-odmnvv7m 123 13 has have VBZ cord-276616-odmnvv7m 123 14 been be VBN cord-276616-odmnvv7m 123 15 seen see VBN cord-276616-odmnvv7m 123 16 in in IN cord-276616-odmnvv7m 123 17 the the DT cord-276616-odmnvv7m 123 18 cerebrum cerebrum NN cord-276616-odmnvv7m 123 19 of of IN cord-276616-odmnvv7m 123 20 mice mouse NNS cord-276616-odmnvv7m 123 21 infected infect VBN cord-276616-odmnvv7m 123 22 with with IN cord-276616-odmnvv7m 123 23 a a DT cord-276616-odmnvv7m 123 24 parainfluenza parainfluenza NNP cord-276616-odmnvv7m 123 25 virus virus NN cord-276616-odmnvv7m 124 1 ( ( -LRB- cord-276616-odmnvv7m 124 2 Baringer Baringer NNP cord-276616-odmnvv7m 124 3 et et NNP cord-276616-odmnvv7m 124 4 aL aL NNP cord-276616-odmnvv7m 124 5 , , , cord-276616-odmnvv7m 124 6 1979 1979 CD cord-276616-odmnvv7m 124 7 ) ) -RRB- cord-276616-odmnvv7m 125 1 and and CC cord-276616-odmnvv7m 125 2 also also RB cord-276616-odmnvv7m 125 3 in in IN cord-276616-odmnvv7m 125 4 lymphoma lymphoma NN cord-276616-odmnvv7m 125 5 - - HYPH cord-276616-odmnvv7m 125 6 prone prone JJ cord-276616-odmnvv7m 125 7 wild wild JJ cord-276616-odmnvv7m 125 8 mice mouse NNS cord-276616-odmnvv7m 126 1 ( ( -LRB- cord-276616-odmnvv7m 126 2 Gardner Gardner NNP cord-276616-odmnvv7m 126 3 et et NNP cord-276616-odmnvv7m 126 4 al al NNP cord-276616-odmnvv7m 126 5 . . NNP cord-276616-odmnvv7m 126 6 , , , cord-276616-odmnvv7m 126 7 1979 1979 CD cord-276616-odmnvv7m 126 8 ) ) -RRB- cord-276616-odmnvv7m 126 9 . . . cord-276616-odmnvv7m 127 1 Nevertheless nevertheless RB cord-276616-odmnvv7m 127 2 , , , cord-276616-odmnvv7m 127 3 such such JJ cord-276616-odmnvv7m 127 4 vacuoles vacuole NNS cord-276616-odmnvv7m 127 5 are be VBP cord-276616-odmnvv7m 127 6 a a DT cord-276616-odmnvv7m 127 7 good good JJ cord-276616-odmnvv7m 127 8 diagnostic diagnostic JJ cord-276616-odmnvv7m 127 9 aid aid NN cord-276616-odmnvv7m 127 10 . . . cord-276616-odmnvv7m 128 1 As as IN cord-276616-odmnvv7m 128 2 ' ' `` cord-276616-odmnvv7m 128 3 empty empty JJ cord-276616-odmnvv7m 128 4 ' ' '' cord-276616-odmnvv7m 128 5 inclusions inclusion NNS cord-276616-odmnvv7m 128 6 , , , cord-276616-odmnvv7m 128 7 they -PRON- PRP cord-276616-odmnvv7m 128 8 presumably presumably RB cord-276616-odmnvv7m 128 9 represent represent VBP cord-276616-odmnvv7m 128 10 unstainable unstainable JJ cord-276616-odmnvv7m 128 11 material material NN cord-276616-odmnvv7m 128 12 , , , cord-276616-odmnvv7m 128 13 fluid fluid NN cord-276616-odmnvv7m 128 14 , , , cord-276616-odmnvv7m 128 15 gas gas NN cord-276616-odmnvv7m 128 16 or or CC cord-276616-odmnvv7m 128 17 volatile volatile JJ cord-276616-odmnvv7m 128 18 hydrocarbon hydrocarbon NN cord-276616-odmnvv7m 128 19 2 2 CD cord-276616-odmnvv7m 128 20 . . . cord-276616-odmnvv7m 129 1 The the DT cord-276616-odmnvv7m 129 2 possibility possibility NN cord-276616-odmnvv7m 129 3 of of IN cord-276616-odmnvv7m 129 4 these these DT cord-276616-odmnvv7m 129 5 vacuoles vacuole NNS cord-276616-odmnvv7m 129 6 representing represent VBG cord-276616-odmnvv7m 129 7 unstainable unstainable JJ cord-276616-odmnvv7m 129 8 material material NN cord-276616-odmnvv7m 129 9 was be VBD cord-276616-odmnvv7m 129 10 addressed address VBN cord-276616-odmnvv7m 129 11 many many JJ cord-276616-odmnvv7m 129 12 years year NNS cord-276616-odmnvv7m 129 13 ago ago RB cord-276616-odmnvv7m 129 14 by by IN cord-276616-odmnvv7m 129 15 Darcel Darcel NNP cord-276616-odmnvv7m 129 16 and and CC cord-276616-odmnvv7m 129 17 colleagues colleague NNS cord-276616-odmnvv7m 129 18 ( ( -LRB- cord-276616-odmnvv7m 129 19 1961 1961 CD cord-276616-odmnvv7m 129 20 ) ) -RRB- cord-276616-odmnvv7m 129 21 . . . cord-276616-odmnvv7m 130 1 These these DT cord-276616-odmnvv7m 130 2 authors author NNS cord-276616-odmnvv7m 130 3 were be VBD cord-276616-odmnvv7m 130 4 aware aware JJ cord-276616-odmnvv7m 130 5 of of IN cord-276616-odmnvv7m 130 6 two two CD cord-276616-odmnvv7m 130 7 familial familial JJ cord-276616-odmnvv7m 130 8 diseases disease NNS cord-276616-odmnvv7m 130 9 in in IN cord-276616-odmnvv7m 130 10 man man NN cord-276616-odmnvv7m 130 11 : : : cord-276616-odmnvv7m 130 12 Castaigne Castaigne NNP cord-276616-odmnvv7m 130 13 - - HYPH cord-276616-odmnvv7m 130 14 Lhermite Lhermite NNP cord-276616-odmnvv7m 130 15 's 's POS cord-276616-odmnvv7m 130 16 and and CC cord-276616-odmnvv7m 130 17 Wilson Wilson NNP cord-276616-odmnvv7m 130 18 's 's POS cord-276616-odmnvv7m 130 19 diseases disease NNS cord-276616-odmnvv7m 130 20 . . . cord-276616-odmnvv7m 131 1 In in IN cord-276616-odmnvv7m 131 2 both both DT cord-276616-odmnvv7m 131 3 diseases disease NNS cord-276616-odmnvv7m 131 4 , , , cord-276616-odmnvv7m 131 5 the the DT cord-276616-odmnvv7m 131 6 patient patient NN cord-276616-odmnvv7m 131 7 's 's POS cord-276616-odmnvv7m 131 8 behaviour behaviour NN cord-276616-odmnvv7m 131 9 shows show VBZ cord-276616-odmnvv7m 131 10 some some DT cord-276616-odmnvv7m 131 11 resemblance resemblance NN cord-276616-odmnvv7m 131 12 to to IN cord-276616-odmnvv7m 131 13 certain certain JJ cord-276616-odmnvv7m 131 14 signs sign NNS cord-276616-odmnvv7m 131 15 seen see VBN cord-276616-odmnvv7m 131 16 with with IN cord-276616-odmnvv7m 131 17 the the DT cord-276616-odmnvv7m 131 18 spongiform spongiform JJ cord-276616-odmnvv7m 131 19 encephalopathies encephalopathy NNS cord-276616-odmnvv7m 131 20 , , , cord-276616-odmnvv7m 131 21 namely namely RB cord-276616-odmnvv7m 131 22 a a DT cord-276616-odmnvv7m 131 23 motor motor NN cord-276616-odmnvv7m 131 24 disability disability NN cord-276616-odmnvv7m 131 25 in in IN cord-276616-odmnvv7m 131 26 the the DT cord-276616-odmnvv7m 131 27 first first JJ cord-276616-odmnvv7m 131 28 disease disease NN cord-276616-odmnvv7m 131 29 , , , cord-276616-odmnvv7m 131 30 a a DT cord-276616-odmnvv7m 131 31 progressive progressive JJ cord-276616-odmnvv7m 131 32 rigidity rigidity NN cord-276616-odmnvv7m 131 33 , , , cord-276616-odmnvv7m 131 34 a a DT cord-276616-odmnvv7m 131 35 coarse coarse JJ cord-276616-odmnvv7m 131 36 tremor tremor NN cord-276616-odmnvv7m 131 37 of of IN cord-276616-odmnvv7m 131 38 the the DT cord-276616-odmnvv7m 131 39 limbs limb NNS cord-276616-odmnvv7m 131 40 , , , cord-276616-odmnvv7m 131 41 and and CC cord-276616-odmnvv7m 131 42 some some DT cord-276616-odmnvv7m 131 43 degree degree NN cord-276616-odmnvv7m 131 44 of of IN cord-276616-odmnvv7m 131 45 dementia dementia NN cord-276616-odmnvv7m 131 46 in in IN cord-276616-odmnvv7m 131 47 the the DT cord-276616-odmnvv7m 131 48 second second NN cord-276616-odmnvv7m 131 49 . . . cord-276616-odmnvv7m 132 1 In in IN cord-276616-odmnvv7m 132 2 Castaigne Castaigne NNP cord-276616-odmnvv7m 132 3 - - HYPH cord-276616-odmnvv7m 132 4 Lhermite Lhermite NNP cord-276616-odmnvv7m 132 5 's 's POS cord-276616-odmnvv7m 132 6 disease disease NN cord-276616-odmnvv7m 132 7 , , , cord-276616-odmnvv7m 132 8 histological histological JJ cord-276616-odmnvv7m 132 9 examination examination NN cord-276616-odmnvv7m 132 10 of of IN cord-276616-odmnvv7m 132 11 the the DT cord-276616-odmnvv7m 132 12 nervous nervous JJ cord-276616-odmnvv7m 132 13 system system NN cord-276616-odmnvv7m 132 14 reveals reveal VBZ cord-276616-odmnvv7m 132 15 the the DT cord-276616-odmnvv7m 132 16 accumulation accumulation NN cord-276616-odmnvv7m 132 17 of of IN cord-276616-odmnvv7m 132 18 glycogen glycogen NN cord-276616-odmnvv7m 132 19 within within IN cord-276616-odmnvv7m 132 20 the the DT cord-276616-odmnvv7m 132 21 nerve nerve NN cord-276616-odmnvv7m 132 22 cells cell NNS cord-276616-odmnvv7m 132 23 , , , cord-276616-odmnvv7m 132 24 varying vary VBG cord-276616-odmnvv7m 132 25 from from IN cord-276616-odmnvv7m 132 26 small small JJ cord-276616-odmnvv7m 132 27 droplets droplet NNS cord-276616-odmnvv7m 132 28 to to IN cord-276616-odmnvv7m 132 29 large large JJ cord-276616-odmnvv7m 132 30 masses masse NNS cord-276616-odmnvv7m 132 31 . . . cord-276616-odmnvv7m 133 1 In in IN cord-276616-odmnvv7m 133 2 Wilson Wilson NNP cord-276616-odmnvv7m 133 3 's 's POS cord-276616-odmnvv7m 133 4 disease disease NN cord-276616-odmnvv7m 133 5 , , , cord-276616-odmnvv7m 133 6 where where WRB cord-276616-odmnvv7m 133 7 the the DT cord-276616-odmnvv7m 133 8 onset onset NN cord-276616-odmnvv7m 133 9 is be VBZ cord-276616-odmnvv7m 133 10 most most RBS cord-276616-odmnvv7m 133 11 common common JJ cord-276616-odmnvv7m 133 12 in in IN cord-276616-odmnvv7m 133 13 the the DT cord-276616-odmnvv7m 133 14 second second JJ cord-276616-odmnvv7m 133 15 decade decade NN cord-276616-odmnvv7m 133 16 of of IN cord-276616-odmnvv7m 133 17 life life NN cord-276616-odmnvv7m 133 18 , , , cord-276616-odmnvv7m 133 19 copper copper NN cord-276616-odmnvv7m 133 20 accumulates accumulate VBZ cord-276616-odmnvv7m 133 21 in in IN cord-276616-odmnvv7m 133 22 large large JJ cord-276616-odmnvv7m 133 23 amounts amount NNS cord-276616-odmnvv7m 133 24 in in IN cord-276616-odmnvv7m 133 25 the the DT cord-276616-odmnvv7m 133 26 corpus corpus NNP cord-276616-odmnvv7m 133 27 striatum striatum NN cord-276616-odmnvv7m 133 28 and and CC cord-276616-odmnvv7m 133 29 in in IN cord-276616-odmnvv7m 133 30 other other JJ cord-276616-odmnvv7m 133 31 tissues tissue NNS cord-276616-odmnvv7m 133 32 . . . cord-276616-odmnvv7m 134 1 While while IN cord-276616-odmnvv7m 134 2 there there EX cord-276616-odmnvv7m 134 3 are be VBP cord-276616-odmnvv7m 134 4 differences difference NNS cord-276616-odmnvv7m 134 5 in in IN cord-276616-odmnvv7m 134 6 the the DT cord-276616-odmnvv7m 134 7 clinical clinical JJ cord-276616-odmnvv7m 134 8 signs sign NNS cord-276616-odmnvv7m 134 9 and and CC cord-276616-odmnvv7m 134 10 the the DT cord-276616-odmnvv7m 134 11 histopathology histopathology NN cord-276616-odmnvv7m 134 12 shown show VBN cord-276616-odmnvv7m 134 13 by by IN cord-276616-odmnvv7m 134 14 both both DT cord-276616-odmnvv7m 134 15 diseases disease NNS cord-276616-odmnvv7m 134 16 from from IN cord-276616-odmnvv7m 134 17 those those DT cord-276616-odmnvv7m 134 18 seen see VBN cord-276616-odmnvv7m 134 19 in in IN cord-276616-odmnvv7m 134 20 scrapie scrapie NN cord-276616-odmnvv7m 134 21 , , , cord-276616-odmnvv7m 134 22 it -PRON- PRP cord-276616-odmnvv7m 134 23 was be VBD cord-276616-odmnvv7m 134 24 thought think VBN cord-276616-odmnvv7m 134 25 worthwhile worthwhile JJ cord-276616-odmnvv7m 134 26 to to TO cord-276616-odmnvv7m 134 27 determine determine VB cord-276616-odmnvv7m 134 28 the the DT cord-276616-odmnvv7m 134 29 glycogen glycogen NN cord-276616-odmnvv7m 134 30 and and CC cord-276616-odmnvv7m 134 31 copper copper NN cord-276616-odmnvv7m 134 32 levels level NNS cord-276616-odmnvv7m 134 33 in in IN cord-276616-odmnvv7m 134 34 the the DT cord-276616-odmnvv7m 134 35 brains brain NNS cord-276616-odmnvv7m 134 36 of of IN cord-276616-odmnvv7m 134 37 sheep sheep NNS cord-276616-odmnvv7m 134 38 with with IN cord-276616-odmnvv7m 134 39 experimentally experimentally RB cord-276616-odmnvv7m 134 40 induced induce VBN cord-276616-odmnvv7m 134 41 scrapie scrapie NN cord-276616-odmnvv7m 134 42 . . . cord-276616-odmnvv7m 135 1 The the DT cord-276616-odmnvv7m 135 2 levels level NNS cord-276616-odmnvv7m 135 3 of of IN cord-276616-odmnvv7m 135 4 neither neither DT cord-276616-odmnvv7m 135 5 copper copper NN cord-276616-odmnvv7m 135 6 nor nor CC cord-276616-odmnvv7m 135 7 glycogen glycogen NN cord-276616-odmnvv7m 135 8 were be VBD cord-276616-odmnvv7m 135 9 elevated elevate VBN cord-276616-odmnvv7m 135 10 compared compare VBN cord-276616-odmnvv7m 135 11 to to IN cord-276616-odmnvv7m 135 12 the the DT cord-276616-odmnvv7m 135 13 values value NNS cord-276616-odmnvv7m 135 14 found find VBN cord-276616-odmnvv7m 135 15 in in IN cord-276616-odmnvv7m 135 16 the the DT cord-276616-odmnvv7m 135 17 brain brain NN cord-276616-odmnvv7m 135 18 of of IN cord-276616-odmnvv7m 135 19 normal normal JJ cord-276616-odmnvv7m 135 20 sheep sheep NN cord-276616-odmnvv7m 135 21 3 3 CD cord-276616-odmnvv7m 135 22 . . . cord-276616-odmnvv7m 136 1 With with IN cord-276616-odmnvv7m 136 2 respect respect NN cord-276616-odmnvv7m 136 3 to to IN cord-276616-odmnvv7m 136 4 the the DT cord-276616-odmnvv7m 136 5 vacuoles vacuole NNS cord-276616-odmnvv7m 136 6 representing represent VBG cord-276616-odmnvv7m 136 7 fluid fluid JJ cord-276616-odmnvv7m 136 8 accumulations accumulation NNS cord-276616-odmnvv7m 136 9 , , , cord-276616-odmnvv7m 136 10 this this DT cord-276616-odmnvv7m 136 11 is be VBZ cord-276616-odmnvv7m 136 12 judged judge VBN cord-276616-odmnvv7m 136 13 unlikely unlikely JJ cord-276616-odmnvv7m 136 14 because because IN cord-276616-odmnvv7m 136 15 body body NN cord-276616-odmnvv7m 136 16 fluids fluid NNS cord-276616-odmnvv7m 136 17 , , , cord-276616-odmnvv7m 136 18 even even RB cord-276616-odmnvv7m 136 19 cerebrospinal cerebrospinal JJ cord-276616-odmnvv7m 136 20 fluid fluid NN cord-276616-odmnvv7m 136 21 , , , cord-276616-odmnvv7m 136 22 contain contain VBP cord-276616-odmnvv7m 136 23 protein protein NN cord-276616-odmnvv7m 136 24 which which WDT cord-276616-odmnvv7m 136 25 is be VBZ cord-276616-odmnvv7m 136 26 stainable stainable JJ cord-276616-odmnvv7m 136 27 by by IN cord-276616-odmnvv7m 136 28 routine routine JJ cord-276616-odmnvv7m 136 29 histological histological JJ cord-276616-odmnvv7m 136 30 procedures procedure NNS cord-276616-odmnvv7m 136 31 . . . cord-276616-odmnvv7m 137 1 We -PRON- PRP cord-276616-odmnvv7m 137 2 are be VBP cord-276616-odmnvv7m 137 3 left leave VBN cord-276616-odmnvv7m 137 4 with with IN cord-276616-odmnvv7m 137 5 the the DT cord-276616-odmnvv7m 137 6 possibility possibility NN cord-276616-odmnvv7m 137 7 that that IN cord-276616-odmnvv7m 137 8 these these DT cord-276616-odmnvv7m 137 9 vacuoles vacuole NNS cord-276616-odmnvv7m 137 10 result result VBP cord-276616-odmnvv7m 137 11 from from IN cord-276616-odmnvv7m 137 12 the the DT cord-276616-odmnvv7m 137 13 accumulation accumulation NN cord-276616-odmnvv7m 137 14 of of IN cord-276616-odmnvv7m 137 15 gas gas NN cord-276616-odmnvv7m 137 16 in in IN cord-276616-odmnvv7m 137 17 the the DT cord-276616-odmnvv7m 137 18 form form NN cord-276616-odmnvv7m 137 19 of of IN cord-276616-odmnvv7m 137 20 bubbles bubble NNS cord-276616-odmnvv7m 137 21 or or CC cord-276616-odmnvv7m 137 22 the the DT cord-276616-odmnvv7m 137 23 presence presence NN cord-276616-odmnvv7m 137 24 of of IN cord-276616-odmnvv7m 137 25 inclusions inclusion NNS cord-276616-odmnvv7m 137 26 of of IN cord-276616-odmnvv7m 137 27 volatile volatile JJ cord-276616-odmnvv7m 137 28 hydrocarbons hydrocarbon NNS cord-276616-odmnvv7m 137 29 . . . cord-276616-odmnvv7m 138 1 The the DT cord-276616-odmnvv7m 138 2 most most RBS cord-276616-odmnvv7m 138 3 likely likely JJ cord-276616-odmnvv7m 138 4 gases gas NNS cord-276616-odmnvv7m 138 5 to to TO cord-276616-odmnvv7m 138 6 be be VB cord-276616-odmnvv7m 138 7 released release VBN cord-276616-odmnvv7m 138 8 would would MD cord-276616-odmnvv7m 138 9 be be VB cord-276616-odmnvv7m 138 10 oxygen oxygen NN cord-276616-odmnvv7m 138 11 or or CC cord-276616-odmnvv7m 138 12 carbon carbon NN cord-276616-odmnvv7m 138 13 dioxide dioxide NN cord-276616-odmnvv7m 138 14 . . . cord-276616-odmnvv7m 139 1 The the DT cord-276616-odmnvv7m 139 2 latter latter JJ cord-276616-odmnvv7m 139 3 would would MD cord-276616-odmnvv7m 139 4 be be VB cord-276616-odmnvv7m 139 5 taken take VBN cord-276616-odmnvv7m 139 6 up up RP cord-276616-odmnvv7m 139 7 by by IN cord-276616-odmnvv7m 139 8 the the DT cord-276616-odmnvv7m 139 9 buffering buffering NN cord-276616-odmnvv7m 139 10 action action NN cord-276616-odmnvv7m 139 11 of of IN cord-276616-odmnvv7m 139 12 the the DT cord-276616-odmnvv7m 139 13 tissues tissue NNS cord-276616-odmnvv7m 139 14 , , , cord-276616-odmnvv7m 139 15 while while IN cord-276616-odmnvv7m 139 16 oxygen oxygen NN cord-276616-odmnvv7m 139 17 free free JJ cord-276616-odmnvv7m 139 18 radicals radical NNS cord-276616-odmnvv7m 139 19 are be VBP cord-276616-odmnvv7m 139 20 released release VBN cord-276616-odmnvv7m 139 21 by by IN cord-276616-odmnvv7m 139 22 enzymes enzyme NNS cord-276616-odmnvv7m 139 23 such such JJ cord-276616-odmnvv7m 139 24 as as IN cord-276616-odmnvv7m 140 1 the the DT cord-276616-odmnvv7m 140 2 O O NNP cord-276616-odmnvv7m 140 3 2-and 2-and CD cord-276616-odmnvv7m 140 4 H20-forming H20-forming NNP cord-276616-odmnvv7m 140 5 oxidases oxidase NNS cord-276616-odmnvv7m 140 6 4 4 CD cord-276616-odmnvv7m 140 7 . . . cord-276616-odmnvv7m 141 1 In in IN cord-276616-odmnvv7m 141 2 the the DT cord-276616-odmnvv7m 141 3 blood blood NN cord-276616-odmnvv7m 141 4 , , , cord-276616-odmnvv7m 141 5 molecular molecular JJ cord-276616-odmnvv7m 141 6 O o NN cord-276616-odmnvv7m 141 7 2 2 CD cord-276616-odmnvv7m 141 8 would would MD cord-276616-odmnvv7m 141 9 be be VB cord-276616-odmnvv7m 141 10 quickly quickly RB cord-276616-odmnvv7m 141 11 bound bind VBN cord-276616-odmnvv7m 141 12 by by IN cord-276616-odmnvv7m 141 13 haemoglobin haemoglobin NN cord-276616-odmnvv7m 141 14 in in IN cord-276616-odmnvv7m 141 15 the the DT cord-276616-odmnvv7m 141 16 red red JJ cord-276616-odmnvv7m 141 17 cells cell NNS cord-276616-odmnvv7m 141 18 , , , cord-276616-odmnvv7m 141 19 but but CC cord-276616-odmnvv7m 141 20 most most JJS cord-276616-odmnvv7m 141 21 locations location NNS cord-276616-odmnvv7m 141 22 in in IN cord-276616-odmnvv7m 141 23 the the DT cord-276616-odmnvv7m 141 24 brain brain NN cord-276616-odmnvv7m 141 25 are be VBP cord-276616-odmnvv7m 141 26 beyond beyond IN cord-276616-odmnvv7m 141 27 the the DT cord-276616-odmnvv7m 141 28 ' ' `` cord-276616-odmnvv7m 141 29 blood blood NN cord-276616-odmnvv7m 141 30 - - HYPH cord-276616-odmnvv7m 141 31 brain brain NN cord-276616-odmnvv7m 141 32 barrier barrier NN cord-276616-odmnvv7m 141 33 ' ' '' cord-276616-odmnvv7m 141 34 and and CC cord-276616-odmnvv7m 141 35 , , , cord-276616-odmnvv7m 141 36 there there RB cord-276616-odmnvv7m 141 37 , , , cord-276616-odmnvv7m 141 38 oxygen oxygen NN cord-276616-odmnvv7m 141 39 would would MD cord-276616-odmnvv7m 141 40 be be VB cord-276616-odmnvv7m 141 41 poorly poorly RB cord-276616-odmnvv7m 141 42 soluble soluble JJ cord-276616-odmnvv7m 141 43 and and CC cord-276616-odmnvv7m 141 44 quite quite RB cord-276616-odmnvv7m 141 45 toxic toxic JJ cord-276616-odmnvv7m 141 46 . . . cord-276616-odmnvv7m 142 1 With with IN cord-276616-odmnvv7m 142 2 regard regard NN cord-276616-odmnvv7m 142 3 to to IN cord-276616-odmnvv7m 142 4 the the DT cord-276616-odmnvv7m 142 5 possibility possibility NN cord-276616-odmnvv7m 142 6 of of IN cord-276616-odmnvv7m 142 7 the the DT cord-276616-odmnvv7m 142 8 vacuoles vacuole NNS cord-276616-odmnvv7m 142 9 being be VBG cord-276616-odmnvv7m 142 10 due due JJ cord-276616-odmnvv7m 142 11 to to IN cord-276616-odmnvv7m 142 12 volatile volatile JJ cord-276616-odmnvv7m 142 13 hydrocarbons hydrocarbon NNS cord-276616-odmnvv7m 142 14 , , , cord-276616-odmnvv7m 142 15 both both CC cord-276616-odmnvv7m 142 16 ethane ethane NN cord-276616-odmnvv7m 142 17 and and CC cord-276616-odmnvv7m 142 18 pentane pentane NNS cord-276616-odmnvv7m 142 19 are be VBP cord-276616-odmnvv7m 142 20 released release VBN cord-276616-odmnvv7m 142 21 from from IN cord-276616-odmnvv7m 142 22 cells cell NNS cord-276616-odmnvv7m 142 23 when when WRB cord-276616-odmnvv7m 142 24 there there EX cord-276616-odmnvv7m 142 25 is be VBZ cord-276616-odmnvv7m 142 26 peroxidation peroxidation NN cord-276616-odmnvv7m 142 27 of of IN cord-276616-odmnvv7m 142 28 polyunsaturated polyunsaturated JJ cord-276616-odmnvv7m 142 29 lipids lipid NNS cord-276616-odmnvv7m 142 30 ( ( -LRB- cord-276616-odmnvv7m 142 31 Miiller Miiller NNP cord-276616-odmnvv7m 142 32 and and CC cord-276616-odmnvv7m 142 33 Sies Sies NNP cord-276616-odmnvv7m 142 34 , , , cord-276616-odmnvv7m 142 35 1984 1984 CD cord-276616-odmnvv7m 142 36 ) ) -RRB- cord-276616-odmnvv7m 142 37 . . . cord-276616-odmnvv7m 143 1 Efforts effort NNS cord-276616-odmnvv7m 143 2 to to TO cord-276616-odmnvv7m 143 3 detect detect VB cord-276616-odmnvv7m 143 4 evidence evidence NN cord-276616-odmnvv7m 143 5 of of IN cord-276616-odmnvv7m 143 6 such such JJ cord-276616-odmnvv7m 143 7 peroxidation peroxidation NN cord-276616-odmnvv7m 143 8 in in IN cord-276616-odmnvv7m 143 9 brain brain NN cord-276616-odmnvv7m 143 10 tissue tissue NN cord-276616-odmnvv7m 143 11 from from IN cord-276616-odmnvv7m 143 12 cases case NNS cord-276616-odmnvv7m 143 13 of of IN cord-276616-odmnvv7m 143 14 transmissible transmissible JJ cord-276616-odmnvv7m 143 15 encephalopathy encephalopathy NNS cord-276616-odmnvv7m 143 16 have have VBP cord-276616-odmnvv7m 143 17 yet yet RB cord-276616-odmnvv7m 143 18 to to TO cord-276616-odmnvv7m 143 19 be be VB cord-276616-odmnvv7m 143 20 made make VBN cord-276616-odmnvv7m 143 21 . . . cord-276616-odmnvv7m 144 1 Although although IN cord-276616-odmnvv7m 144 2 Hunter Hunter NNP cord-276616-odmnvv7m 144 3 ( ( -LRB- cord-276616-odmnvv7m 144 4 1979 1979 CD cord-276616-odmnvv7m 144 5 ) ) -RRB- cord-276616-odmnvv7m 144 6 lists list VBZ cord-276616-odmnvv7m 144 7 a a DT cord-276616-odmnvv7m 144 8 number number NN cord-276616-odmnvv7m 144 9 of of IN cord-276616-odmnvv7m 144 10 changes change NNS cord-276616-odmnvv7m 144 11 in in IN cord-276616-odmnvv7m 144 12 the the DT cord-276616-odmnvv7m 144 13 brain brain NN cord-276616-odmnvv7m 144 14 with with IN cord-276616-odmnvv7m 144 15 the the DT cord-276616-odmnvv7m 144 16 progress progress NN cord-276616-odmnvv7m 144 17 of of IN cord-276616-odmnvv7m 144 18 scrapie scrapie NN cord-276616-odmnvv7m 144 19 , , , cord-276616-odmnvv7m 144 20 neither neither CC cord-276616-odmnvv7m 144 21 this this DT cord-276616-odmnvv7m 144 22 nor nor CC cord-276616-odmnvv7m 144 23 a a DT cord-276616-odmnvv7m 144 24 survey survey NN cord-276616-odmnvv7m 144 25 of of IN cord-276616-odmnvv7m 144 26 the the DT cord-276616-odmnvv7m 144 27 literature literature NN cord-276616-odmnvv7m 144 28 shows show VBZ cord-276616-odmnvv7m 144 29 any any DT cord-276616-odmnvv7m 144 30 indication indication NN cord-276616-odmnvv7m 144 31 that that IN cord-276616-odmnvv7m 144 32 the the DT cord-276616-odmnvv7m 144 33 possibility possibility NN cord-276616-odmnvv7m 144 34 that that IN cord-276616-odmnvv7m 144 35 these these DT cord-276616-odmnvv7m 144 36 vacuoles vacuole NNS cord-276616-odmnvv7m 144 37 are be VBP cord-276616-odmnvv7m 144 38 gas gas NN cord-276616-odmnvv7m 144 39 inclusions inclusion NNS cord-276616-odmnvv7m 144 40 has have VBZ cord-276616-odmnvv7m 144 41 been be VBN cord-276616-odmnvv7m 144 42 vigorously vigorously RB cord-276616-odmnvv7m 144 43 researched research VBN cord-276616-odmnvv7m 144 44 . . . cord-276616-odmnvv7m 145 1 Resolution resolution NN cord-276616-odmnvv7m 145 2 of of IN cord-276616-odmnvv7m 145 3 this this DT cord-276616-odmnvv7m 145 4 problem problem NN cord-276616-odmnvv7m 145 5 could could MD cord-276616-odmnvv7m 145 6 have have VB cord-276616-odmnvv7m 145 7 led lead VBN cord-276616-odmnvv7m 145 8 to to IN cord-276616-odmnvv7m 145 9 a a DT cord-276616-odmnvv7m 145 10 more more RBR cord-276616-odmnvv7m 145 11 directed direct VBN cord-276616-odmnvv7m 145 12 approach approach NN cord-276616-odmnvv7m 145 13 to to IN cord-276616-odmnvv7m 145 14 the the DT cord-276616-odmnvv7m 145 15 biochemical biochemical JJ cord-276616-odmnvv7m 145 16 changes change NNS cord-276616-odmnvv7m 145 17 that that WDT cord-276616-odmnvv7m 145 18 occur occur VBP cord-276616-odmnvv7m 145 19 in in IN cord-276616-odmnvv7m 145 20 the the DT cord-276616-odmnvv7m 145 21 encephalopathies encephalopathy NNS cord-276616-odmnvv7m 145 22 . . . cord-276616-odmnvv7m 146 1 Biochemical biochemical JJ cord-276616-odmnvv7m 146 2 changes change NNS cord-276616-odmnvv7m 146 3 that that WDT cord-276616-odmnvv7m 146 4 have have VBP cord-276616-odmnvv7m 146 5 been be VBN cord-276616-odmnvv7m 146 6 noted note VBN cord-276616-odmnvv7m 146 7 include include VBP cord-276616-odmnvv7m 146 8 changes change NNS cord-276616-odmnvv7m 146 9 in in IN cord-276616-odmnvv7m 146 10 amino amino JJ cord-276616-odmnvv7m 146 11 acids acid NNS cord-276616-odmnvv7m 146 12 in in IN cord-276616-odmnvv7m 146 13 the the DT cord-276616-odmnvv7m 146 14 blood blood NN cord-276616-odmnvv7m 146 15 plasma plasma NN cord-276616-odmnvv7m 146 16 and and CC cord-276616-odmnvv7m 146 17 brain brain NN cord-276616-odmnvv7m 146 18 tissue tissue NN cord-276616-odmnvv7m 146 19 but but CC cord-276616-odmnvv7m 146 20 , , , cord-276616-odmnvv7m 146 21 except except IN cord-276616-odmnvv7m 146 22 for for IN cord-276616-odmnvv7m 146 23 great great JJ cord-276616-odmnvv7m 146 24 increases increase NNS cord-276616-odmnvv7m 146 25 in in IN cord-276616-odmnvv7m 146 26 the the DT cord-276616-odmnvv7m 146 27 activity activity NN cord-276616-odmnvv7m 146 28 of of IN cord-276616-odmnvv7m 146 29 hydrolytic hydrolytic JJ cord-276616-odmnvv7m 146 30 enzymes enzyme NNS cord-276616-odmnvv7m 146 31 , , , cord-276616-odmnvv7m 146 32 evidence evidence NN cord-276616-odmnvv7m 146 33 of of IN cord-276616-odmnvv7m 146 34 other other JJ cord-276616-odmnvv7m 146 35 biochemical biochemical JJ cord-276616-odmnvv7m 146 36 alterations alteration NNS cord-276616-odmnvv7m 146 37 in in IN cord-276616-odmnvv7m 146 38 the the DT cord-276616-odmnvv7m 146 39 brain brain NN cord-276616-odmnvv7m 146 40 , , , cord-276616-odmnvv7m 146 41 plasma plasma NN cord-276616-odmnvv7m 146 42 and and CC cord-276616-odmnvv7m 146 43 urine urine NN cord-276616-odmnvv7m 146 44 is be VBZ cord-276616-odmnvv7m 146 45 scanty scanty JJ cord-276616-odmnvv7m 147 1 ( ( -LRB- cord-276616-odmnvv7m 147 2 Kimberlin Kimberlin NNP cord-276616-odmnvv7m 147 3 , , , cord-276616-odmnvv7m 147 4 1976b 1976b CD cord-276616-odmnvv7m 147 5 ) ) -RRB- cord-276616-odmnvv7m 147 6 . . . cord-276616-odmnvv7m 148 1 Liver liver NN cord-276616-odmnvv7m 148 2 function function NN cord-276616-odmnvv7m 148 3 is be VBZ cord-276616-odmnvv7m 148 4 normal normal JJ cord-276616-odmnvv7m 148 5 . . . cord-276616-odmnvv7m 149 1 However however RB cord-276616-odmnvv7m 149 2 , , , cord-276616-odmnvv7m 149 3 there there EX cord-276616-odmnvv7m 149 4 has have VBZ cord-276616-odmnvv7m 149 5 been be VBN cord-276616-odmnvv7m 149 6 the the DT cord-276616-odmnvv7m 149 7 recent recent JJ cord-276616-odmnvv7m 149 8 observation observation NN cord-276616-odmnvv7m 149 9 in in IN cord-276616-odmnvv7m 149 10 one one CD cord-276616-odmnvv7m 149 11 case case NN cord-276616-odmnvv7m 149 12 of of IN cord-276616-odmnvv7m 149 13 BSE BSE NNP cord-276616-odmnvv7m 149 14 of of IN cord-276616-odmnvv7m 149 15 a a DT cord-276616-odmnvv7m 149 16 very very RB cord-276616-odmnvv7m 149 17 high high JJ cord-276616-odmnvv7m 149 18 plasma plasma NN cord-276616-odmnvv7m 149 19 glucose glucose NN cord-276616-odmnvv7m 149 20 concentration concentration NN cord-276616-odmnvv7m 149 21 ( ( -LRB- cord-276616-odmnvv7m 149 22 Scott Scott NNP cord-276616-odmnvv7m 149 23 et et NNP cord-276616-odmnvv7m 149 24 aL aL NNP cord-276616-odmnvv7m 149 25 , , , cord-276616-odmnvv7m 149 26 1988 1988 CD cord-276616-odmnvv7m 149 27 ) ) -RRB- cord-276616-odmnvv7m 149 28 . . . cord-276616-odmnvv7m 150 1 More More JJR cord-276616-odmnvv7m 150 2 data datum NNS cord-276616-odmnvv7m 150 3 are be VBP cord-276616-odmnvv7m 150 4 needed need VBN cord-276616-odmnvv7m 150 5 as as IN cord-276616-odmnvv7m 150 6 consistently consistently RB cord-276616-odmnvv7m 150 7 high high JJ cord-276616-odmnvv7m 150 8 blood blood NN cord-276616-odmnvv7m 150 9 glucose glucose NN cord-276616-odmnvv7m 150 10 could could MD cord-276616-odmnvv7m 150 11 point point VB cord-276616-odmnvv7m 150 12 to to IN cord-276616-odmnvv7m 150 13 other other JJ cord-276616-odmnvv7m 150 14 biochemical biochemical JJ cord-276616-odmnvv7m 150 15 investigations investigation NNS cord-276616-odmnvv7m 150 16 that that WDT cord-276616-odmnvv7m 150 17 should should MD cord-276616-odmnvv7m 150 18 be be VB cord-276616-odmnvv7m 150 19 made make VBN cord-276616-odmnvv7m 150 20 . . . cord-276616-odmnvv7m 151 1 Millson Millson NNP cord-276616-odmnvv7m 151 2 and and CC cord-276616-odmnvv7m 151 3 Bountiff Bountiff NNP cord-276616-odmnvv7m 151 4 ( ( -LRB- cord-276616-odmnvv7m 151 5 1973 1973 CD cord-276616-odmnvv7m 151 6 ) ) -RRB- cord-276616-odmnvv7m 151 7 found find VBD cord-276616-odmnvv7m 151 8 a a DT cord-276616-odmnvv7m 151 9 group group NN cord-276616-odmnvv7m 151 10 of of IN cord-276616-odmnvv7m 151 11 five five CD cord-276616-odmnvv7m 151 12 glycosidases glycosidase NNS cord-276616-odmnvv7m 151 13 that that WDT cord-276616-odmnvv7m 151 14 showed show VBD cord-276616-odmnvv7m 151 15 greatly greatly RB cord-276616-odmnvv7m 151 16 increased increase VBN cord-276616-odmnvv7m 151 17 activity activity NN cord-276616-odmnvv7m 151 18 in in IN cord-276616-odmnvv7m 151 19 the the DT cord-276616-odmnvv7m 151 20 brain brain NN cord-276616-odmnvv7m 151 21 of of IN cord-276616-odmnvv7m 151 22 mice mouse NNS cord-276616-odmnvv7m 151 23 with with IN cord-276616-odmnvv7m 151 24 clinical clinical JJ cord-276616-odmnvv7m 151 25 signs sign NNS cord-276616-odmnvv7m 151 26 following follow VBG cord-276616-odmnvv7m 151 27 inoculation inoculation NN cord-276616-odmnvv7m 151 28 of of IN cord-276616-odmnvv7m 151 29 the the DT cord-276616-odmnvv7m 151 30 agent agent NN cord-276616-odmnvv7m 151 31 , , , cord-276616-odmnvv7m 151 32 four four CD cord-276616-odmnvv7m 151 33 of of IN cord-276616-odmnvv7m 151 34 these these DT cord-276616-odmnvv7m 151 35 showing show VBG cord-276616-odmnvv7m 151 36 an an DT cord-276616-odmnvv7m 151 37 increase increase NN cord-276616-odmnvv7m 151 38 before before IN cord-276616-odmnvv7m 151 39 clinical clinical JJ cord-276616-odmnvv7m 151 40 signs sign NNS cord-276616-odmnvv7m 151 41 appeared appear VBD cord-276616-odmnvv7m 151 42 . . . cord-276616-odmnvv7m 152 1 One one CD cord-276616-odmnvv7m 152 2 wonders wonder VBZ cord-276616-odmnvv7m 152 3 whether whether IN cord-276616-odmnvv7m 152 4 such such JJ cord-276616-odmnvv7m 152 5 increased increase VBN cord-276616-odmnvv7m 152 6 activity activity NN cord-276616-odmnvv7m 152 7 would would MD cord-276616-odmnvv7m 152 8 spill spill VB cord-276616-odmnvv7m 152 9 over over RP cord-276616-odmnvv7m 152 10 into into IN cord-276616-odmnvv7m 152 11 the the DT cord-276616-odmnvv7m 152 12 plasma plasma NN cord-276616-odmnvv7m 152 13 and and CC cord-276616-odmnvv7m 152 14 be be VB cord-276616-odmnvv7m 152 15 usable usable JJ cord-276616-odmnvv7m 152 16 for for IN cord-276616-odmnvv7m 152 17 an an DT cord-276616-odmnvv7m 152 18 early early JJ cord-276616-odmnvv7m 152 19 diagnostic diagnostic JJ cord-276616-odmnvv7m 152 20 test test NN cord-276616-odmnvv7m 152 21 for for IN cord-276616-odmnvv7m 152 22 the the DT cord-276616-odmnvv7m 152 23 development development NN cord-276616-odmnvv7m 152 24 of of IN cord-276616-odmnvv7m 152 25 a a DT cord-276616-odmnvv7m 152 26 spongiform spongiform JJ cord-276616-odmnvv7m 152 27 encephalopathy encephalopathy NN cord-276616-odmnvv7m 152 28 . . . cord-276616-odmnvv7m 153 1 Scrapie Scrapie NNP cord-276616-odmnvv7m 153 2 is be VBZ cord-276616-odmnvv7m 153 3 transmissible transmissible JJ cord-276616-odmnvv7m 153 4 , , , cord-276616-odmnvv7m 153 5 but but CC cord-276616-odmnvv7m 153 6 the the DT cord-276616-odmnvv7m 153 7 causative causative JJ cord-276616-odmnvv7m 153 8 agent agent NN cord-276616-odmnvv7m 153 9 has have VBZ cord-276616-odmnvv7m 153 10 not not RB cord-276616-odmnvv7m 153 11 been be VBN cord-276616-odmnvv7m 153 12 shown show VBN cord-276616-odmnvv7m 153 13 to to TO cord-276616-odmnvv7m 153 14 be be VB cord-276616-odmnvv7m 153 15 a a DT cord-276616-odmnvv7m 153 16 virus virus NN cord-276616-odmnvv7m 153 17 . . . cord-276616-odmnvv7m 154 1 One one CD cord-276616-odmnvv7m 154 2 of of IN cord-276616-odmnvv7m 154 3 the the DT cord-276616-odmnvv7m 154 4 difficulties difficulty NNS cord-276616-odmnvv7m 154 5 in in IN cord-276616-odmnvv7m 154 6 accepting accept VBG cord-276616-odmnvv7m 154 7 a a DT cord-276616-odmnvv7m 154 8 conventional conventional JJ cord-276616-odmnvv7m 154 9 virus virus NN cord-276616-odmnvv7m 154 10 as as IN cord-276616-odmnvv7m 154 11 the the DT cord-276616-odmnvv7m 154 12 agent agent NN cord-276616-odmnvv7m 154 13 has have VBZ cord-276616-odmnvv7m 154 14 been be VBN cord-276616-odmnvv7m 154 15 its -PRON- PRP$ cord-276616-odmnvv7m 154 16 resistance resistance NN cord-276616-odmnvv7m 154 17 to to TO cord-276616-odmnvv7m 154 18 damage damage VB cord-276616-odmnvv7m 154 19 with with IN cord-276616-odmnvv7m 154 20 a a DT cord-276616-odmnvv7m 154 21 variety variety NN cord-276616-odmnvv7m 154 22 of of IN cord-276616-odmnvv7m 154 23 agencies agency NNS cord-276616-odmnvv7m 154 24 . . . cord-276616-odmnvv7m 155 1 In in IN cord-276616-odmnvv7m 155 2 spite spite NN cord-276616-odmnvv7m 155 3 of of IN cord-276616-odmnvv7m 155 4 this this DT cord-276616-odmnvv7m 155 5 , , , cord-276616-odmnvv7m 155 6 a a DT cord-276616-odmnvv7m 155 7 viral viral JJ cord-276616-odmnvv7m 155 8 aetiology aetiology NN cord-276616-odmnvv7m 155 9 has have VBZ cord-276616-odmnvv7m 155 10 not not RB cord-276616-odmnvv7m 155 11 yet yet RB cord-276616-odmnvv7m 155 12 been be VBN cord-276616-odmnvv7m 155 13 excluded exclude VBN cord-276616-odmnvv7m 155 14 . . . cord-276616-odmnvv7m 156 1 The the DT cord-276616-odmnvv7m 156 2 possibility possibility NN cord-276616-odmnvv7m 156 3 has have VBZ cord-276616-odmnvv7m 156 4 recently recently RB cord-276616-odmnvv7m 156 5 been be VBN cord-276616-odmnvv7m 156 6 advanced advance VBN cord-276616-odmnvv7m 156 7 that that IN cord-276616-odmnvv7m 156 8 mollicutes mollicutes NNP cord-276616-odmnvv7m 156 9 ( ( -LRB- cord-276616-odmnvv7m 156 10 spiroplasmas spiroplasmas NNP cord-276616-odmnvv7m 156 11 ) ) -RRB- cord-276616-odmnvv7m 156 12 are be VBP cord-276616-odmnvv7m 156 13 responsible responsible JJ cord-276616-odmnvv7m 156 14 ( ( -LRB- cord-276616-odmnvv7m 156 15 see see VB cord-276616-odmnvv7m 156 16 below below RB cord-276616-odmnvv7m 156 17 ) ) -RRB- cord-276616-odmnvv7m 156 18 , , , cord-276616-odmnvv7m 156 19 but but CC cord-276616-odmnvv7m 156 20 most most RBS cord-276616-odmnvv7m 156 21 current current JJ cord-276616-odmnvv7m 156 22 thinking thinking NN cord-276616-odmnvv7m 156 23 envisages envisage VBZ cord-276616-odmnvv7m 156 24 a a DT cord-276616-odmnvv7m 156 25 different different JJ cord-276616-odmnvv7m 156 26 kind kind NN cord-276616-odmnvv7m 156 27 of of IN cord-276616-odmnvv7m 156 28 transmissible transmissible JJ cord-276616-odmnvv7m 156 29 agent agent NN cord-276616-odmnvv7m 156 30 . . . cord-276616-odmnvv7m 157 1 Two two CD cord-276616-odmnvv7m 157 2 such such JJ cord-276616-odmnvv7m 157 3 agents agent NNS cord-276616-odmnvv7m 157 4 have have VBP cord-276616-odmnvv7m 157 5 been be VBN cord-276616-odmnvv7m 157 6 postulated postulate VBN cord-276616-odmnvv7m 157 7 -'prions -'prions NNPS cord-276616-odmnvv7m 157 8 ' ' POS cord-276616-odmnvv7m 157 9 and and CC cord-276616-odmnvv7m 157 10 ' ' `` cord-276616-odmnvv7m 157 11 virinos virinos NN cord-276616-odmnvv7m 157 12 ' ' '' cord-276616-odmnvv7m 157 13 . . . cord-276616-odmnvv7m 158 1 The the DT cord-276616-odmnvv7m 158 2 ' ' `` cord-276616-odmnvv7m 158 3 priori priori FW cord-276616-odmnvv7m 158 4 ' ' '' cord-276616-odmnvv7m 158 5 was be VBD cord-276616-odmnvv7m 158 6 postulated postulate VBN cord-276616-odmnvv7m 158 7 to to TO cord-276616-odmnvv7m 158 8 be be VB cord-276616-odmnvv7m 158 9 an an DT cord-276616-odmnvv7m 158 10 infectious infectious JJ cord-276616-odmnvv7m 158 11 protein protein NN cord-276616-odmnvv7m 158 12 that that WDT cord-276616-odmnvv7m 158 13 directs direct VBZ cord-276616-odmnvv7m 158 14 its -PRON- PRP$ cord-276616-odmnvv7m 158 15 own own JJ cord-276616-odmnvv7m 158 16 replication replication NN cord-276616-odmnvv7m 158 17 ( ( -LRB- cord-276616-odmnvv7m 158 18 Prusiner Prusiner NNP cord-276616-odmnvv7m 158 19 , , , cord-276616-odmnvv7m 158 20 1982 1982 CD cord-276616-odmnvv7m 158 21 ) ) -RRB- cord-276616-odmnvv7m 158 22 . . . cord-276616-odmnvv7m 159 1 The the DT cord-276616-odmnvv7m 159 2 ' ' `` cord-276616-odmnvv7m 159 3 virino virino NN cord-276616-odmnvv7m 159 4 ' ' '' cord-276616-odmnvv7m 159 5 hypothesis hypothesis NN cord-276616-odmnvv7m 159 6 suggests suggest VBZ cord-276616-odmnvv7m 159 7 the the DT cord-276616-odmnvv7m 159 8 existence existence NN cord-276616-odmnvv7m 159 9 of of IN cord-276616-odmnvv7m 159 10 a a DT cord-276616-odmnvv7m 159 11 very very RB cord-276616-odmnvv7m 159 12 small small JJ cord-276616-odmnvv7m 159 13 scrapie scrapie NN cord-276616-odmnvv7m 159 14 - - HYPH cord-276616-odmnvv7m 159 15 specific specific JJ cord-276616-odmnvv7m 159 16 nucleic nucleic JJ cord-276616-odmnvv7m 159 17 acid acid NN cord-276616-odmnvv7m 159 18 ( ( -LRB- cord-276616-odmnvv7m 159 19 Dickinson Dickinson NNP cord-276616-odmnvv7m 159 20 and and CC cord-276616-odmnvv7m 159 21 Outram Outram NNP cord-276616-odmnvv7m 159 22 , , , cord-276616-odmnvv7m 159 23 1988 1988 CD cord-276616-odmnvv7m 159 24 ) ) -RRB- cord-276616-odmnvv7m 159 25 . . . cord-276616-odmnvv7m 160 1 Evidence evidence NN cord-276616-odmnvv7m 160 2 for for IN cord-276616-odmnvv7m 160 3 the the DT cord-276616-odmnvv7m 160 4 priori priori FW cord-276616-odmnvv7m 160 5 and and CC cord-276616-odmnvv7m 160 6 virino virino NN cord-276616-odmnvv7m 160 7 and and CC cord-276616-odmnvv7m 160 8 other other JJ cord-276616-odmnvv7m 160 9 possible possible JJ cord-276616-odmnvv7m 160 10 hypotheses hypothesis NNS cord-276616-odmnvv7m 160 11 for for IN cord-276616-odmnvv7m 160 12 the the DT cord-276616-odmnvv7m 160 13 causation causation NN cord-276616-odmnvv7m 160 14 of of IN cord-276616-odmnvv7m 160 15 the the DT cord-276616-odmnvv7m 160 16 encephalopathies encephalopathy NNS cord-276616-odmnvv7m 160 17 will will MD cord-276616-odmnvv7m 160 18 now now RB cord-276616-odmnvv7m 160 19 be be VB cord-276616-odmnvv7m 160 20 considered consider VBN cord-276616-odmnvv7m 160 21 . . . cord-276616-odmnvv7m 161 1 The the DT cord-276616-odmnvv7m 161 2 variety variety NN cord-276616-odmnvv7m 161 3 in in IN cord-276616-odmnvv7m 161 4 the the DT cord-276616-odmnvv7m 161 5 infective infective JJ cord-276616-odmnvv7m 161 6 agents agent NNS cord-276616-odmnvv7m 161 7 that that WDT cord-276616-odmnvv7m 161 8 can can MD cord-276616-odmnvv7m 161 9 cause cause VB cord-276616-odmnvv7m 161 10 disease disease NN cord-276616-odmnvv7m 161 11 is be VBZ cord-276616-odmnvv7m 161 12 awe awe NN cord-276616-odmnvv7m 161 13 - - HYPH cord-276616-odmnvv7m 161 14 inspiring inspire VBG cord-276616-odmnvv7m 161 15 , , , cord-276616-odmnvv7m 161 16 particularly particularly RB cord-276616-odmnvv7m 161 17 with with IN cord-276616-odmnvv7m 161 18 regard regard NN cord-276616-odmnvv7m 161 19 to to IN cord-276616-odmnvv7m 161 20 the the DT cord-276616-odmnvv7m 161 21 way way NN cord-276616-odmnvv7m 161 22 they -PRON- PRP cord-276616-odmnvv7m 161 23 are be VBP cord-276616-odmnvv7m 161 24 propagated propagate VBN cord-276616-odmnvv7m 161 25 , , , cord-276616-odmnvv7m 161 26 retain retain VB cord-276616-odmnvv7m 161 27 their -PRON- PRP$ cord-276616-odmnvv7m 161 28 characters character NNS cord-276616-odmnvv7m 161 29 , , , cord-276616-odmnvv7m 161 30 and and CC cord-276616-odmnvv7m 161 31 cause cause VB cord-276616-odmnvv7m 161 32 problems problem NNS cord-276616-odmnvv7m 161 33 for for IN cord-276616-odmnvv7m 161 34 the the DT cord-276616-odmnvv7m 161 35 host host NN cord-276616-odmnvv7m 161 36 . . . cord-276616-odmnvv7m 162 1 With with IN cord-276616-odmnvv7m 162 2 bacteria bacteria NNS cord-276616-odmnvv7m 162 3 and and CC cord-276616-odmnvv7m 162 4 viruses virus NNS cord-276616-odmnvv7m 162 5 , , , cord-276616-odmnvv7m 162 6 the the DT cord-276616-odmnvv7m 162 7 infective infective JJ cord-276616-odmnvv7m 162 8 agent agent NN cord-276616-odmnvv7m 162 9 carries carry VBZ cord-276616-odmnvv7m 162 10 its -PRON- PRP$ cord-276616-odmnvv7m 162 11 own own JJ cord-276616-odmnvv7m 162 12 genetic genetic JJ cord-276616-odmnvv7m 162 13 material material NN cord-276616-odmnvv7m 162 14 in in IN cord-276616-odmnvv7m 162 15 the the DT cord-276616-odmnvv7m 162 16 form form NN cord-276616-odmnvv7m 162 17 of of IN cord-276616-odmnvv7m 162 18 either either DT cord-276616-odmnvv7m 162 19 RNA RNA NNP cord-276616-odmnvv7m 162 20 or or CC cord-276616-odmnvv7m 162 21 DNA DNA NNP cord-276616-odmnvv7m 162 22 , , , cord-276616-odmnvv7m 162 23 but but CC cord-276616-odmnvv7m 162 24 a a DT cord-276616-odmnvv7m 162 25 decade decade NN cord-276616-odmnvv7m 162 26 ago ago RB cord-276616-odmnvv7m 162 27 it -PRON- PRP cord-276616-odmnvv7m 162 28 was be VBD cord-276616-odmnvv7m 162 29 suggested suggest VBN cord-276616-odmnvv7m 162 30 that that IN cord-276616-odmnvv7m 162 31 an an DT cord-276616-odmnvv7m 162 32 altered altered JJ cord-276616-odmnvv7m 162 33 protein protein NN cord-276616-odmnvv7m 162 34 can can MD cord-276616-odmnvv7m 162 35 itself -PRON- PRP cord-276616-odmnvv7m 162 36 transmit transmit VB cord-276616-odmnvv7m 162 37 the the DT cord-276616-odmnvv7m 162 38 encephalopathies encephalopathy NNS cord-276616-odmnvv7m 162 39 . . . cord-276616-odmnvv7m 163 1 This this DT cord-276616-odmnvv7m 163 2 is be VBZ cord-276616-odmnvv7m 163 3 the the DT cord-276616-odmnvv7m 163 4 prion prion NN cord-276616-odmnvv7m 163 5 PrPSc prpsc NN cord-276616-odmnvv7m 163 6 ( ( -LRB- cord-276616-odmnvv7m 163 7 Prusiner Prusiner NNP cord-276616-odmnvv7m 163 8 , , , cord-276616-odmnvv7m 163 9 1982 1982 CD cord-276616-odmnvv7m 163 10 ) ) -RRB- cord-276616-odmnvv7m 163 11 , , , cord-276616-odmnvv7m 163 12 or or CC cord-276616-odmnvv7m 163 13 scrapie scrapie NN cord-276616-odmnvv7m 163 14 - - HYPH cord-276616-odmnvv7m 163 15 associated associate VBN cord-276616-odmnvv7m 163 16 fibril fibril NN cord-276616-odmnvv7m 163 17 protein protein NN cord-276616-odmnvv7m 163 18 ( ( -LRB- cord-276616-odmnvv7m 163 19 SAF SAF NNP cord-276616-odmnvv7m 163 20 ) ) -RRB- cord-276616-odmnvv7m 163 21 , , , cord-276616-odmnvv7m 163 22 which which WDT cord-276616-odmnvv7m 163 23 is be VBZ cord-276616-odmnvv7m 163 24 present present JJ cord-276616-odmnvv7m 163 25 as as IN cord-276616-odmnvv7m 163 26 fibrils fibril NNS cord-276616-odmnvv7m 163 27 or or CC cord-276616-odmnvv7m 163 28 rods rod NNS cord-276616-odmnvv7m 163 29 , , , cord-276616-odmnvv7m 163 30 33 33 CD cord-276616-odmnvv7m 163 31 - - SYM cord-276616-odmnvv7m 163 32 35 35 CD cord-276616-odmnvv7m 163 33 kDa kDa NNS cord-276616-odmnvv7m 163 34 in in IN cord-276616-odmnvv7m 163 35 size size NN cord-276616-odmnvv7m 163 36 , , , cord-276616-odmnvv7m 163 37 that that DT cord-276616-odmnvv7m 163 38 can can MD cord-276616-odmnvv7m 163 39 be be VB cord-276616-odmnvv7m 163 40 seen see VBN cord-276616-odmnvv7m 163 41 by by IN cord-276616-odmnvv7m 163 42 electron electron NN cord-276616-odmnvv7m 163 43 microscopy microscopy NNP cord-276616-odmnvv7m 163 44 intracellularly intracellularly RB cord-276616-odmnvv7m 163 45 and and CC cord-276616-odmnvv7m 163 46 extracellularly extracellularly RB cord-276616-odmnvv7m 163 47 in in IN cord-276616-odmnvv7m 163 48 the the DT cord-276616-odmnvv7m 163 49 brain brain NN cord-276616-odmnvv7m 163 50 of of IN cord-276616-odmnvv7m 163 51 animals animal NNS cord-276616-odmnvv7m 163 52 affected affect VBN cord-276616-odmnvv7m 163 53 by by IN cord-276616-odmnvv7m 163 54 scrapie scrapie NN cord-276616-odmnvv7m 163 55 . . . cord-276616-odmnvv7m 164 1 PrPSc PrPSc NNP cord-276616-odmnvv7m 164 2 is be VBZ cord-276616-odmnvv7m 164 3 heterogenous heterogenous JJ cord-276616-odmnvv7m 164 4 on on IN cord-276616-odmnvv7m 164 5 electrophoresis electrophoresis NN cord-276616-odmnvv7m 164 6 , , , cord-276616-odmnvv7m 164 7 although although IN cord-276616-odmnvv7m 164 8 this this DT cord-276616-odmnvv7m 164 9 may may MD cord-276616-odmnvv7m 164 10 be be VB cord-276616-odmnvv7m 164 11 due due JJ cord-276616-odmnvv7m 164 12 to to IN cord-276616-odmnvv7m 164 13 different different JJ cord-276616-odmnvv7m 164 14 degrees degree NNS cord-276616-odmnvv7m 164 15 of of IN cord-276616-odmnvv7m 164 16 glycosylation glycosylation NN cord-276616-odmnvv7m 164 17 of of IN cord-276616-odmnvv7m 164 18 this this DT cord-276616-odmnvv7m 164 19 sialo sialo NN cord-276616-odmnvv7m 164 20 - - HYPH cord-276616-odmnvv7m 164 21 glycoprotein glycoprotein NN cord-276616-odmnvv7m 164 22 ( ( -LRB- cord-276616-odmnvv7m 164 23 Somerville Somerville NNP cord-276616-odmnvv7m 164 24 and and CC cord-276616-odmnvv7m 164 25 Ritchie Ritchie NNP cord-276616-odmnvv7m 164 26 , , , cord-276616-odmnvv7m 164 27 1990 1990 CD cord-276616-odmnvv7m 164 28 ) ) -RRB- cord-276616-odmnvv7m 164 29 . . . cord-276616-odmnvv7m 165 1 Species species NN cord-276616-odmnvv7m 165 2 differences difference NNS cord-276616-odmnvv7m 165 3 have have VBP cord-276616-odmnvv7m 165 4 been be VBN cord-276616-odmnvv7m 165 5 found find VBN cord-276616-odmnvv7m 165 6 in in IN cord-276616-odmnvv7m 165 7 bovine bovine JJ cord-276616-odmnvv7m 165 8 , , , cord-276616-odmnvv7m 165 9 murine murine JJ cord-276616-odmnvv7m 165 10 and and CC cord-276616-odmnvv7m 165 11 ovine ovine JJ cord-276616-odmnvv7m 165 12 PrPSc prpsc NN cord-276616-odmnvv7m 165 13 ( ( -LRB- cord-276616-odmnvv7m 165 14 Groschup Groschup NNP cord-276616-odmnvv7m 165 15 and and CC cord-276616-odmnvv7m 165 16 Pfaff Pfaff NNP cord-276616-odmnvv7m 165 17 , , , cord-276616-odmnvv7m 165 18 1993 1993 CD cord-276616-odmnvv7m 165 19 ) ) -RRB- cord-276616-odmnvv7m 165 20 . . . cord-276616-odmnvv7m 166 1 The the DT cord-276616-odmnvv7m 166 2 homozygous homozygous JJ cord-276616-odmnvv7m 166 3 PrP prp NN cord-276616-odmnvv7m 166 4 genotype genotype NN cord-276616-odmnvv7m 166 5 has have VBZ cord-276616-odmnvv7m 166 6 been be VBN cord-276616-odmnvv7m 166 7 found find VBN cord-276616-odmnvv7m 166 8 to to TO cord-276616-odmnvv7m 166 9 predispose predispose VB cord-276616-odmnvv7m 166 10 to to IN cord-276616-odmnvv7m 166 11 sporadic sporadic JJ cord-276616-odmnvv7m 166 12 CAD CAD NNP cord-276616-odmnvv7m 166 13 ( ( -LRB- cord-276616-odmnvv7m 166 14 Palmer Palmer NNP cord-276616-odmnvv7m 166 15 et et NNP cord-276616-odmnvv7m 166 16 al al NNP cord-276616-odmnvv7m 166 17 . . NNP cord-276616-odmnvv7m 166 18 , , , cord-276616-odmnvv7m 166 19 1991 1991 CD cord-276616-odmnvv7m 166 20 ) ) -RRB- cord-276616-odmnvv7m 166 21 and and CC cord-276616-odmnvv7m 166 22 a a DT cord-276616-odmnvv7m 166 23 prion prion NN cord-276616-odmnvv7m 166 24 protein protein NN cord-276616-odmnvv7m 166 25 missense missense NN cord-276616-odmnvv7m 166 26 variant variant NN cord-276616-odmnvv7m 166 27 is be VBZ cord-276616-odmnvv7m 166 28 linked link VBN cord-276616-odmnvv7m 166 29 to to IN cord-276616-odmnvv7m 166 30 the the DT cord-276616-odmnvv7m 166 31 occurrence occurrence NN cord-276616-odmnvv7m 166 32 of of IN cord-276616-odmnvv7m 166 33 GSSD GSSD NNP cord-276616-odmnvv7m 167 1 ( ( -LRB- cord-276616-odmnvv7m 167 2 Hsiao Hsiao NNP cord-276616-odmnvv7m 167 3 et et FW cord-276616-odmnvv7m 167 4 al al NNP cord-276616-odmnvv7m 167 5 . . NNP cord-276616-odmnvv7m 167 6 , , , cord-276616-odmnvv7m 167 7 1989 1989 CD cord-276616-odmnvv7m 167 8 ) ) -RRB- cord-276616-odmnvv7m 167 9 . . . cord-276616-odmnvv7m 168 1 The the DT cord-276616-odmnvv7m 168 2 possibility possibility NN cord-276616-odmnvv7m 168 3 that that IN cord-276616-odmnvv7m 168 4 protein protein NN cord-276616-odmnvv7m 168 5 can can MD cord-276616-odmnvv7m 168 6 be be VB cord-276616-odmnvv7m 168 7 infectious infectious JJ cord-276616-odmnvv7m 168 8 in in IN cord-276616-odmnvv7m 168 9 the the DT cord-276616-odmnvv7m 168 10 absence absence NN cord-276616-odmnvv7m 168 11 of of IN cord-276616-odmnvv7m 168 12 an an DT cord-276616-odmnvv7m 168 13 association association NN cord-276616-odmnvv7m 168 14 with with IN cord-276616-odmnvv7m 168 15 nucleic nucleic JJ cord-276616-odmnvv7m 168 16 acid acid NN cord-276616-odmnvv7m 168 17 is be VBZ cord-276616-odmnvv7m 168 18 intriguing intriguing JJ cord-276616-odmnvv7m 168 19 . . . cord-276616-odmnvv7m 169 1 Prion prion NN cord-276616-odmnvv7m 169 2 protein protein NN cord-276616-odmnvv7m 169 3 and and CC cord-276616-odmnvv7m 169 4 scrapie scrapie NN cord-276616-odmnvv7m 169 5 - - HYPH cord-276616-odmnvv7m 169 6 associated associate VBN cord-276616-odmnvv7m 169 7 fibrils fibril NNS cord-276616-odmnvv7m 169 8 are be VBP cord-276616-odmnvv7m 169 9 especially especially RB cord-276616-odmnvv7m 169 10 characteristic characteristic JJ cord-276616-odmnvv7m 169 11 of of IN cord-276616-odmnvv7m 169 12 brain brain NN cord-276616-odmnvv7m 169 13 lesions lesion NNS cord-276616-odmnvv7m 169 14 in in IN cord-276616-odmnvv7m 169 15 scrapie scrapie NN cord-276616-odmnvv7m 169 16 ( ( -LRB- cord-276616-odmnvv7m 169 17 Merz Merz NNP cord-276616-odmnvv7m 169 18 et et NNP cord-276616-odmnvv7m 169 19 aL aL NNP cord-276616-odmnvv7m 169 20 , , , cord-276616-odmnvv7m 169 21 1981 1981 CD cord-276616-odmnvv7m 169 22 ; ; : cord-276616-odmnvv7m 169 23 Bolton Bolton NNP cord-276616-odmnvv7m 169 24 et et NNP cord-276616-odmnvv7m 169 25 aL aL NNP cord-276616-odmnvv7m 169 26 , , , cord-276616-odmnvv7m 169 27 1982 1982 CD cord-276616-odmnvv7m 169 28 ) ) -RRB- cord-276616-odmnvv7m 169 29 . . . cord-276616-odmnvv7m 170 1 However however RB cord-276616-odmnvv7m 170 2 , , , cord-276616-odmnvv7m 170 3 although although IN cord-276616-odmnvv7m 170 4 hamster hamster NN cord-276616-odmnvv7m 170 5 and and CC cord-276616-odmnvv7m 170 6 mouse mouse NN cord-276616-odmnvv7m 170 7 spleen spleen NNS cord-276616-odmnvv7m 170 8 contain contain VBP cord-276616-odmnvv7m 170 9 only only RB cord-276616-odmnvv7m 170 10 low low JJ cord-276616-odmnvv7m 170 11 levels level NNS cord-276616-odmnvv7m 170 12 of of IN cord-276616-odmnvv7m 170 13 PrP prp NN cord-276616-odmnvv7m 170 14 mRNA mRNA NNP cord-276616-odmnvv7m 170 15 , , , cord-276616-odmnvv7m 170 16 they -PRON- PRP cord-276616-odmnvv7m 170 17 can can MD cord-276616-odmnvv7m 170 18 contain contain VB cord-276616-odmnvv7m 170 19 large large JJ cord-276616-odmnvv7m 170 20 amounts amount NNS cord-276616-odmnvv7m 170 21 of of IN cord-276616-odmnvv7m 170 22 the the DT cord-276616-odmnvv7m 170 23 transmissible transmissible JJ cord-276616-odmnvv7m 170 24 agent agent NN cord-276616-odmnvv7m 170 25 . . . cord-276616-odmnvv7m 171 1 This this DT cord-276616-odmnvv7m 171 2 is be VBZ cord-276616-odmnvv7m 171 3 hardly hardly RB cord-276616-odmnvv7m 171 4 good good JJ cord-276616-odmnvv7m 171 5 evidence evidence NN cord-276616-odmnvv7m 171 6 that that IN cord-276616-odmnvv7m 171 7 the the DT cord-276616-odmnvv7m 171 8 prion prion NN cord-276616-odmnvv7m 171 9 is be VBZ cord-276616-odmnvv7m 171 10 the the DT cord-276616-odmnvv7m 171 11 infective infective JJ cord-276616-odmnvv7m 171 12 agent agent NN cord-276616-odmnvv7m 171 13 . . . cord-276616-odmnvv7m 172 1 Kitamoto Kitamoto NNP cord-276616-odmnvv7m 172 2 and and CC cord-276616-odmnvv7m 172 3 colleagues colleague NNS cord-276616-odmnvv7m 172 4 ( ( -LRB- cord-276616-odmnvv7m 172 5 1989 1989 CD cord-276616-odmnvv7m 172 6 ) ) -RRB- cord-276616-odmnvv7m 172 7 were be VBD cord-276616-odmnvv7m 172 8 able able JJ cord-276616-odmnvv7m 172 9 to to TO cord-276616-odmnvv7m 172 10 demonstrate demonstrate VB cord-276616-odmnvv7m 172 11 a a DT cord-276616-odmnvv7m 172 12 correlation correlation NN cord-276616-odmnvv7m 172 13 between between IN cord-276616-odmnvv7m 172 14 titres titre NNS cord-276616-odmnvv7m 172 15 of of IN cord-276616-odmnvv7m 172 16 the the DT cord-276616-odmnvv7m 172 17 CJD CJD NNP cord-276616-odmnvv7m 172 18 agent agent NN cord-276616-odmnvv7m 172 19 in in IN cord-276616-odmnvv7m 172 20 the the DT cord-276616-odmnvv7m 172 21 brain brain NN cord-276616-odmnvv7m 172 22 and and CC cord-276616-odmnvv7m 172 23 spleens spleen NNS cord-276616-odmnvv7m 172 24 of of IN cord-276616-odmnvv7m 172 25 infected infected JJ cord-276616-odmnvv7m 172 26 mice mouse NNS cord-276616-odmnvv7m 172 27 and and CC cord-276616-odmnvv7m 172 28 their -PRON- PRP$ cord-276616-odmnvv7m 172 29 content content NN cord-276616-odmnvv7m 172 30 of of IN cord-276616-odmnvv7m 172 31 PrP prp NN cord-276616-odmnvv7m 172 32 , , , cord-276616-odmnvv7m 172 33 while while IN cord-276616-odmnvv7m 172 34 Czub Czub NNP cord-276616-odmnvv7m 172 35 and and CC cord-276616-odmnvv7m 172 36 colleagues colleague NNS cord-276616-odmnvv7m 172 37 ( ( -LRB- cord-276616-odmnvv7m 172 38 1986 1986 CD cord-276616-odmnvv7m 172 39 ) ) -RRB- cord-276616-odmnvv7m 172 40 were be VBD cord-276616-odmnvv7m 172 41 not not RB cord-276616-odmnvv7m 172 42 able able JJ cord-276616-odmnvv7m 172 43 to to TO cord-276616-odmnvv7m 172 44 do do VB cord-276616-odmnvv7m 172 45 so so RB cord-276616-odmnvv7m 172 46 for for IN cord-276616-odmnvv7m 172 47 scrapie scrapie NN cord-276616-odmnvv7m 172 48 . . . cord-276616-odmnvv7m 173 1 Unfortunately unfortunately RB cord-276616-odmnvv7m 173 2 , , , cord-276616-odmnvv7m 173 3 it -PRON- PRP cord-276616-odmnvv7m 173 4 is be VBZ cord-276616-odmnvv7m 173 5 difficult difficult JJ cord-276616-odmnvv7m 173 6 to to TO cord-276616-odmnvv7m 173 7 resolve resolve VB cord-276616-odmnvv7m 173 8 this this DT cord-276616-odmnvv7m 173 9 question question NN cord-276616-odmnvv7m 173 10 , , , cord-276616-odmnvv7m 173 11 since since IN cord-276616-odmnvv7m 173 12 titration titration NN cord-276616-odmnvv7m 173 13 of of IN cord-276616-odmnvv7m 173 14 the the DT cord-276616-odmnvv7m 173 15 scrapie scrapie NN cord-276616-odmnvv7m 173 16 agent agent NN cord-276616-odmnvv7m 173 17 is be VBZ cord-276616-odmnvv7m 173 18 attended attend VBN cord-276616-odmnvv7m 173 19 with with IN cord-276616-odmnvv7m 173 20 wide wide JJ cord-276616-odmnvv7m 173 21 errors error NNS cord-276616-odmnvv7m 173 22 ( ( -LRB- cord-276616-odmnvv7m 173 23 Marsh Marsh NNP cord-276616-odmnvv7m 173 24 et et NNP cord-276616-odmnvv7m 173 25 aL aL NNP cord-276616-odmnvv7m 173 26 , , , cord-276616-odmnvv7m 173 27 1984 1984 CD cord-276616-odmnvv7m 173 28 ) ) -RRB- cord-276616-odmnvv7m 173 29 and and CC cord-276616-odmnvv7m 174 1 the the DT cord-276616-odmnvv7m 174 2 specificity specificity NN cord-276616-odmnvv7m 174 3 of of IN cord-276616-odmnvv7m 174 4 serological serological JJ cord-276616-odmnvv7m 174 5 methods method NNS cord-276616-odmnvv7m 174 6 for for IN cord-276616-odmnvv7m 174 7 determining determine VBG cord-276616-odmnvv7m 174 8 SAF SAF NNP cord-276616-odmnvv7m 174 9 / / SYM cord-276616-odmnvv7m 174 10 PrPSc PrPSc NNP cord-276616-odmnvv7m 174 11 is be VBZ cord-276616-odmnvv7m 174 12 open open JJ cord-276616-odmnvv7m 174 13 to to TO cord-276616-odmnvv7m 174 14 question question VB cord-276616-odmnvv7m 174 15 , , , cord-276616-odmnvv7m 174 16 since since IN cord-276616-odmnvv7m 174 17 PrPSc prpsc NN cord-276616-odmnvv7m 174 18 is be VBZ cord-276616-odmnvv7m 174 19 produced produce VBN cord-276616-odmnvv7m 174 20 by by IN cord-276616-odmnvv7m 174 21 the the DT cord-276616-odmnvv7m 174 22 same same JJ cord-276616-odmnvv7m 174 23 gene gene NN cord-276616-odmnvv7m 174 24 as as IN cord-276616-odmnvv7m 174 25 its -PRON- PRP$ cord-276616-odmnvv7m 174 26 homologous homologous JJ cord-276616-odmnvv7m 174 27 normal normal JJ cord-276616-odmnvv7m 174 28 protein protein NN cord-276616-odmnvv7m 174 29 , , , cord-276616-odmnvv7m 174 30 differing differ VBG cord-276616-odmnvv7m 174 31 only only RB cord-276616-odmnvv7m 174 32 in in IN cord-276616-odmnvv7m 174 33 its -PRON- PRP$ cord-276616-odmnvv7m 174 34 sensitivity sensitivity NN cord-276616-odmnvv7m 174 35 to to IN cord-276616-odmnvv7m 174 36 proteinase proteinase NN cord-276616-odmnvv7m 174 37 - - HYPH cord-276616-odmnvv7m 174 38 K. k. NN cord-276616-odmnvv7m 175 1 Another another DT cord-276616-odmnvv7m 175 2 fact fact NN cord-276616-odmnvv7m 175 3 suggesting suggest VBG cord-276616-odmnvv7m 175 4 that that IN cord-276616-odmnvv7m 175 5 the the DT cord-276616-odmnvv7m 175 6 ' ' `` cord-276616-odmnvv7m 175 7 prion prion NN cord-276616-odmnvv7m 175 8 ' ' '' cord-276616-odmnvv7m 175 9 is be VBZ cord-276616-odmnvv7m 175 10 not not RB cord-276616-odmnvv7m 175 11 the the DT cord-276616-odmnvv7m 175 12 infective infective JJ cord-276616-odmnvv7m 175 13 agent agent NN cord-276616-odmnvv7m 175 14 for for IN cord-276616-odmnvv7m 175 15 scrapie scrapie NN cord-276616-odmnvv7m 175 16 is be VBZ cord-276616-odmnvv7m 175 17 that that IN cord-276616-odmnvv7m 175 18 PrPSc prpsc NN cord-276616-odmnvv7m 175 19 expressed express VBN cord-276616-odmnvv7m 175 20 in in IN cord-276616-odmnvv7m 175 21 vitro vitro FW cord-276616-odmnvv7m 175 22 by by IN cord-276616-odmnvv7m 175 23 a a DT cord-276616-odmnvv7m 175 24 cloned clone VBN cord-276616-odmnvv7m 175 25 PrP prp NN cord-276616-odmnvv7m 175 26 gene gene NN cord-276616-odmnvv7m 175 27 is be VBZ cord-276616-odmnvv7m 175 28 ineffective ineffective JJ cord-276616-odmnvv7m 175 29 in in IN cord-276616-odmnvv7m 175 30 inducing induce VBG cord-276616-odmnvv7m 175 31 the the DT cord-276616-odmnvv7m 175 32 disease disease NN cord-276616-odmnvv7m 175 33 . . . cord-276616-odmnvv7m 176 1 When when WRB cord-276616-odmnvv7m 176 2 the the DT cord-276616-odmnvv7m 176 3 hamster hamster NN cord-276616-odmnvv7m 176 4 gene gene NN cord-276616-odmnvv7m 176 5 for for IN cord-276616-odmnvv7m 176 6 expressing express VBG cord-276616-odmnvv7m 176 7 this this DT cord-276616-odmnvv7m 176 8 protein protein NN cord-276616-odmnvv7m 176 9 is be VBZ cord-276616-odmnvv7m 176 10 introduced introduce VBN cord-276616-odmnvv7m 176 11 into into IN cord-276616-odmnvv7m 176 12 mice mouse NNS cord-276616-odmnvv7m 176 13 , , , cord-276616-odmnvv7m 176 14 this this DT cord-276616-odmnvv7m 176 15 species species NN cord-276616-odmnvv7m 176 16 now now RB cord-276616-odmnvv7m 176 17 has have VBZ cord-276616-odmnvv7m 176 18 the the DT cord-276616-odmnvv7m 176 19 susceptibility susceptibility NN cord-276616-odmnvv7m 176 20 to to IN cord-276616-odmnvv7m 176 21 scrapie scrapie NN cord-276616-odmnvv7m 176 22 characteristic characteristic NN cord-276616-odmnvv7m 176 23 of of IN cord-276616-odmnvv7m 176 24 hamsters hamster NNS cord-276616-odmnvv7m 176 25 rather rather RB cord-276616-odmnvv7m 176 26 than than IN cord-276616-odmnvv7m 176 27 the the DT cord-276616-odmnvv7m 176 28 susceptibility susceptibility NN cord-276616-odmnvv7m 176 29 of of IN cord-276616-odmnvv7m 176 30 mice mouse NNS cord-276616-odmnvv7m 176 31 ; ; : cord-276616-odmnvv7m 176 32 the the DT cord-276616-odmnvv7m 176 33 transgenic transgenic JJ cord-276616-odmnvv7m 176 34 mice mouse NNS cord-276616-odmnvv7m 176 35 still still RB cord-276616-odmnvv7m 176 36 have have VBP cord-276616-odmnvv7m 176 37 to to TO cord-276616-odmnvv7m 176 38 be be VB cord-276616-odmnvv7m 176 39 infected infect VBN cord-276616-odmnvv7m 176 40 with with IN cord-276616-odmnvv7m 176 41 the the DT cord-276616-odmnvv7m 176 42 scrapie scrapie NN cord-276616-odmnvv7m 176 43 agent agent NN cord-276616-odmnvv7m 176 44 ( ( -LRB- cord-276616-odmnvv7m 176 45 Scott Scott NNP cord-276616-odmnvv7m 176 46 et et NNP cord-276616-odmnvv7m 176 47 aL aL NNP cord-276616-odmnvv7m 176 48 , , , cord-276616-odmnvv7m 176 49 1989 1989 CD cord-276616-odmnvv7m 176 50 ) ) -RRB- cord-276616-odmnvv7m 176 51 . . . cord-276616-odmnvv7m 177 1 Other other JJ cord-276616-odmnvv7m 177 2 evidence evidence NN cord-276616-odmnvv7m 177 3 indicating indicate VBG cord-276616-odmnvv7m 177 4 that that IN cord-276616-odmnvv7m 177 5 the the DT cord-276616-odmnvv7m 177 6 ' ' `` cord-276616-odmnvv7m 177 7 prion prion NN cord-276616-odmnvv7m 177 8 ' ' '' cord-276616-odmnvv7m 177 9 or or CC cord-276616-odmnvv7m 177 10 SAF SAF NNP cord-276616-odmnvv7m 177 11 is be VBZ cord-276616-odmnvv7m 177 12 not not RB cord-276616-odmnvv7m 177 13 the the DT cord-276616-odmnvv7m 177 14 causative causative JJ cord-276616-odmnvv7m 177 15 agent agent NN cord-276616-odmnvv7m 177 16 of of IN cord-276616-odmnvv7m 177 17 scrapie scrapie NN cord-276616-odmnvv7m 177 18 is be VBZ cord-276616-odmnvv7m 177 19 given give VBN cord-276616-odmnvv7m 177 20 by by IN cord-276616-odmnvv7m 177 21 Braig Braig NNP cord-276616-odmnvv7m 177 22 and and CC cord-276616-odmnvv7m 177 23 Diringer Diringer NNP cord-276616-odmnvv7m 177 24 ( ( -LRB- cord-276616-odmnvv7m 177 25 1985 1985 CD cord-276616-odmnvv7m 177 26 ) ) -RRB- cord-276616-odmnvv7m 177 27 . . . cord-276616-odmnvv7m 178 1 Finally finally RB cord-276616-odmnvv7m 178 2 , , , cord-276616-odmnvv7m 178 3 Bueler Bueler NNP cord-276616-odmnvv7m 178 4 and and CC cord-276616-odmnvv7m 178 5 colleagues colleague NNS cord-276616-odmnvv7m 178 6 ( ( -LRB- cord-276616-odmnvv7m 178 7 1993 1993 CD cord-276616-odmnvv7m 178 8 ) ) -RRB- cord-276616-odmnvv7m 178 9 showed show VBD cord-276616-odmnvv7m 178 10 that that IN cord-276616-odmnvv7m 178 11 mice mouse NNS cord-276616-odmnvv7m 178 12 bred breed VBN cord-276616-odmnvv7m 178 13 for for IN cord-276616-odmnvv7m 178 14 lack lack NN cord-276616-odmnvv7m 178 15 of of IN cord-276616-odmnvv7m 178 16 expression expression NN cord-276616-odmnvv7m 178 17 of of IN cord-276616-odmnvv7m 178 18 the the DT cord-276616-odmnvv7m 178 19 PrP prp NN cord-276616-odmnvv7m 178 20 gene gene NN cord-276616-odmnvv7m 178 21 are be VBP cord-276616-odmnvv7m 178 22 resistant resistant JJ cord-276616-odmnvv7m 178 23 to to IN cord-276616-odmnvv7m 178 24 the the DT cord-276616-odmnvv7m 178 25 development development NN cord-276616-odmnvv7m 178 26 of of IN cord-276616-odmnvv7m 178 27 scrapie scrapie NN cord-276616-odmnvv7m 178 28 . . . cord-276616-odmnvv7m 179 1 After after IN cord-276616-odmnvv7m 179 2 the the DT cord-276616-odmnvv7m 179 3 introduction introduction NN cord-276616-odmnvv7m 179 4 of of IN cord-276616-odmnvv7m 179 5 Syrian syrian JJ cord-276616-odmnvv7m 179 6 hamster hamster NN cord-276616-odmnvv7m 179 7 PrP prp NN cord-276616-odmnvv7m 179 8 transgenes transgene NNS cord-276616-odmnvv7m 179 9 , , , cord-276616-odmnvv7m 179 10 these these DT cord-276616-odmnvv7m 179 11 mice mouse NNS cord-276616-odmnvv7m 179 12 became become VBD cord-276616-odmnvv7m 179 13 highly highly RB cord-276616-odmnvv7m 179 14 susceptible susceptible JJ cord-276616-odmnvv7m 179 15 to to IN cord-276616-odmnvv7m 179 16 hamster hamster NN cord-276616-odmnvv7m 179 17 but but CC cord-276616-odmnvv7m 179 18 not not RB cord-276616-odmnvv7m 179 19 mouse mouse NN cord-276616-odmnvv7m 179 20 prions prion NNS cord-276616-odmnvv7m 179 21 . . . cord-276616-odmnvv7m 180 1 Again again RB cord-276616-odmnvv7m 180 2 , , , cord-276616-odmnvv7m 180 3 it -PRON- PRP cord-276616-odmnvv7m 180 4 has have VBZ cord-276616-odmnvv7m 180 5 been be VBN cord-276616-odmnvv7m 180 6 found find VBN cord-276616-odmnvv7m 180 7 ( ( -LRB- cord-276616-odmnvv7m 180 8 Xi Xi NNP cord-276616-odmnvv7m 180 9 et et NNP cord-276616-odmnvv7m 180 10 aL aL NNP cord-276616-odmnvv7m 180 11 , , , cord-276616-odmnvv7m 180 12 1992 1992 CD cord-276616-odmnvv7m 180 13 ; ; : cord-276616-odmnvv7m 180 14 Demaimay Demaimay NNP cord-276616-odmnvv7m 180 15 et et NNP cord-276616-odmnvv7m 180 16 al al NNP cord-276616-odmnvv7m 180 17 . . . cord-276616-odmnvv7m 181 1 , , , cord-276616-odmnvv7m 181 2 1994 1994 CD cord-276616-odmnvv7m 181 3 ) ) -RRB- cord-276616-odmnvv7m 181 4 that that IN cord-276616-odmnvv7m 181 5 , , , cord-276616-odmnvv7m 181 6 following follow VBG cord-276616-odmnvv7m 181 7 treatment treatment NN cord-276616-odmnvv7m 181 8 of of IN cord-276616-odmnvv7m 181 9 hamsters hamster NNS cord-276616-odmnvv7m 181 10 with with IN cord-276616-odmnvv7m 181 11 amphotericin amphotericin NNS cord-276616-odmnvv7m 181 12 B b NN cord-276616-odmnvv7m 181 13 or or CC cord-276616-odmnvv7m 181 14 a a DT cord-276616-odmnvv7m 181 15 derivative derivative NN cord-276616-odmnvv7m 181 16 of of IN cord-276616-odmnvv7m 181 17 this this DT cord-276616-odmnvv7m 181 18 antibiotic antibiotic NN cord-276616-odmnvv7m 181 19 , , , cord-276616-odmnvv7m 181 20 the the DT cord-276616-odmnvv7m 181 21 accumulation accumulation NN cord-276616-odmnvv7m 181 22 of of IN cord-276616-odmnvv7m 181 23 PrP prp NN cord-276616-odmnvv7m 181 24 was be VBD cord-276616-odmnvv7m 181 25 not not RB cord-276616-odmnvv7m 181 26 correlated correlate VBN cord-276616-odmnvv7m 181 27 with with IN cord-276616-odmnvv7m 181 28 replication replication NN cord-276616-odmnvv7m 181 29 of of IN cord-276616-odmnvv7m 181 30 the the DT cord-276616-odmnvv7m 181 31 scrapie scrapie NN cord-276616-odmnvv7m 181 32 agent agent NN cord-276616-odmnvv7m 181 33 . . . cord-276616-odmnvv7m 182 1 Race race NN cord-276616-odmnvv7m 182 2 and and CC cord-276616-odmnvv7m 182 3 colleagues colleague NNS cord-276616-odmnvv7m 182 4 ( ( -LRB- cord-276616-odmnvv7m 182 5 1988 1988 CD cord-276616-odmnvv7m 182 6 ) ) -RRB- cord-276616-odmnvv7m 182 7 described describe VBD cord-276616-odmnvv7m 182 8 experiments experiment NNS cord-276616-odmnvv7m 182 9 with with IN cord-276616-odmnvv7m 182 10 cloned clone VBN cord-276616-odmnvv7m 182 11 neuroblastoma neuroblastoma NN cord-276616-odmnvv7m 182 12 cultures culture NNS cord-276616-odmnvv7m 182 13 with with IN cord-276616-odmnvv7m 182 14 a a DT cord-276616-odmnvv7m 182 15 high high JJ cord-276616-odmnvv7m 182 16 titre titre NN cord-276616-odmnvv7m 182 17 of of IN cord-276616-odmnvv7m 182 18 the the DT cord-276616-odmnvv7m 182 19 scrapie scrapie NN cord-276616-odmnvv7m 182 20 agent agent NN cord-276616-odmnvv7m 182 21 . . . cord-276616-odmnvv7m 183 1 While while IN cord-276616-odmnvv7m 183 2 these these DT cord-276616-odmnvv7m 183 3 workers worker NNS cord-276616-odmnvv7m 183 4 acknowledged acknowledge VBD cord-276616-odmnvv7m 183 5 that that IN cord-276616-odmnvv7m 183 6 a a DT cord-276616-odmnvv7m 183 7 proteinase proteinase NN cord-276616-odmnvv7m 183 8 - - HYPH cord-276616-odmnvv7m 183 9 K k NN cord-276616-odmnvv7m 183 10 - - HYPH cord-276616-odmnvv7m 183 11 resistant resistant JJ cord-276616-odmnvv7m 183 12 protein protein NN cord-276616-odmnvv7m 183 13 developed develop VBN cord-276616-odmnvv7m 183 14 with with IN cord-276616-odmnvv7m 183 15 scrapie scrapie NN cord-276616-odmnvv7m 183 16 infection infection NN cord-276616-odmnvv7m 183 17 in in IN cord-276616-odmnvv7m 183 18 these these DT cord-276616-odmnvv7m 183 19 experiments experiment NNS cord-276616-odmnvv7m 183 20 , , , cord-276616-odmnvv7m 183 21 they -PRON- PRP cord-276616-odmnvv7m 183 22 found find VBD cord-276616-odmnvv7m 183 23 no no DT cord-276616-odmnvv7m 183 24 evidence evidence NN cord-276616-odmnvv7m 183 25 that that IN cord-276616-odmnvv7m 183 26 the the DT cord-276616-odmnvv7m 183 27 PK PK NNP cord-276616-odmnvv7m 183 28 - - HYPH cord-276616-odmnvv7m 183 29 resistant resistant JJ cord-276616-odmnvv7m 183 30 form form NN cord-276616-odmnvv7m 183 31 of of IN cord-276616-odmnvv7m 183 32 PrP prp NN cord-276616-odmnvv7m 183 33 was be VBD cord-276616-odmnvv7m 183 34 necessary necessary JJ cord-276616-odmnvv7m 183 35 for for IN cord-276616-odmnvv7m 183 36 infectivity infectivity NN cord-276616-odmnvv7m 183 37 . . . cord-276616-odmnvv7m 184 1 They -PRON- PRP cord-276616-odmnvv7m 184 2 concluded conclude VBD cord-276616-odmnvv7m 184 3 that that IN cord-276616-odmnvv7m 184 4 the the DT cord-276616-odmnvv7m 184 5 PK PK NNP cord-276616-odmnvv7m 184 6 - - HYPH cord-276616-odmnvv7m 184 7 resistant resistant JJ cord-276616-odmnvv7m 184 8 PrP prp NN cord-276616-odmnvv7m 184 9 of of IN cord-276616-odmnvv7m 184 10 scrapie scrapie NN cord-276616-odmnvv7m 184 11 arose arise VBD cord-276616-odmnvv7m 184 12 in in IN cord-276616-odmnvv7m 184 13 vivo vivo NN cord-276616-odmnvv7m 184 14 as as IN cord-276616-odmnvv7m 184 15 a a DT cord-276616-odmnvv7m 184 16 result result NN cord-276616-odmnvv7m 184 17 of of IN cord-276616-odmnvv7m 184 18 alteration alteration NN cord-276616-odmnvv7m 184 19 of of IN cord-276616-odmnvv7m 184 20 PK PK NNP cord-276616-odmnvv7m 184 21 - - HYPH cord-276616-odmnvv7m 184 22 sensitive sensitive JJ cord-276616-odmnvv7m 184 23 PrP prp NN cord-276616-odmnvv7m 184 24 by by IN cord-276616-odmnvv7m 184 25 changes change NNS cord-276616-odmnvv7m 184 26 in in IN cord-276616-odmnvv7m 184 27 the the DT cord-276616-odmnvv7m 184 28 physiological physiological JJ cord-276616-odmnvv7m 184 29 conditions condition NNS cord-276616-odmnvv7m 184 30 of of IN cord-276616-odmnvv7m 184 31 cells cell NNS cord-276616-odmnvv7m 184 32 as as IN cord-276616-odmnvv7m 184 33 they -PRON- PRP cord-276616-odmnvv7m 184 34 degenerate degenerate VBP cord-276616-odmnvv7m 184 35 , , , cord-276616-odmnvv7m 184 36 and and CC cord-276616-odmnvv7m 184 37 that that IN cord-276616-odmnvv7m 184 38 the the DT cord-276616-odmnvv7m 184 39 evidence evidence NN cord-276616-odmnvv7m 184 40 for for IN cord-276616-odmnvv7m 184 41 the the DT cord-276616-odmnvv7m 184 42 inseparability inseparability NN cord-276616-odmnvv7m 184 43 of of IN cord-276616-odmnvv7m 184 44 the the DT cord-276616-odmnvv7m 184 45 scrapie scrapie NN cord-276616-odmnvv7m 184 46 agent agent NN cord-276616-odmnvv7m 184 47 and and CC cord-276616-odmnvv7m 184 48 PK PK NNP cord-276616-odmnvv7m 184 49 - - HYPH cord-276616-odmnvv7m 184 50 resistant resistant JJ cord-276616-odmnvv7m 184 51 PrP prp NN cord-276616-odmnvv7m 184 52 was be VBD cord-276616-odmnvv7m 184 53 still still RB cord-276616-odmnvv7m 184 54 circumstantial circumstantial JJ cord-276616-odmnvv7m 184 55 , , , cord-276616-odmnvv7m 184 56 a a DT cord-276616-odmnvv7m 184 57 view view NN cord-276616-odmnvv7m 184 58 not not RB cord-276616-odmnvv7m 184 59 shared share VBN cord-276616-odmnvv7m 184 60 by by IN cord-276616-odmnvv7m 184 61 Bolton Bolton NNP cord-276616-odmnvv7m 184 62 and and CC cord-276616-odmnvv7m 184 63 colleagues colleague NNS cord-276616-odmnvv7m 184 64 ( ( -LRB- cord-276616-odmnvv7m 184 65 1991 1991 CD cord-276616-odmnvv7m 184 66 ) ) -RRB- cord-276616-odmnvv7m 184 67 . . . cord-276616-odmnvv7m 185 1 Caughey Caughey NNP cord-276616-odmnvv7m 185 2 and and CC cord-276616-odmnvv7m 185 3 colleagues colleague NNS cord-276616-odmnvv7m 185 4 ( ( -LRB- cord-276616-odmnvv7m 185 5 1991 1991 CD cord-276616-odmnvv7m 185 6 ) ) -RRB- cord-276616-odmnvv7m 185 7 speculated speculate VBD cord-276616-odmnvv7m 185 8 , , , cord-276616-odmnvv7m 185 9 from from IN cord-276616-odmnvv7m 185 10 further further JJ cord-276616-odmnvv7m 185 11 work work NN cord-276616-odmnvv7m 185 12 on on IN cord-276616-odmnvv7m 185 13 these these DT cord-276616-odmnvv7m 185 14 neuroblastoma neuroblastoma NN cord-276616-odmnvv7m 185 15 cultures culture NNS cord-276616-odmnvv7m 185 16 , , , cord-276616-odmnvv7m 185 17 that that IN cord-276616-odmnvv7m 185 18 the the DT cord-276616-odmnvv7m 185 19 increased increase VBN cord-276616-odmnvv7m 185 20 tendency tendency NN cord-276616-odmnvv7m 185 21 of of IN cord-276616-odmnvv7m 185 22 PrP prp NN cord-276616-odmnvv7m 185 23 to to TO cord-276616-odmnvv7m 185 24 aggregate aggregate VB cord-276616-odmnvv7m 185 25 is be VBZ cord-276616-odmnvv7m 185 26 the the DT cord-276616-odmnvv7m 185 27 origin origin NN cord-276616-odmnvv7m 185 28 of of IN cord-276616-odmnvv7m 185 29 this this DT cord-276616-odmnvv7m 185 30 resistance resistance NN cord-276616-odmnvv7m 185 31 to to IN cord-276616-odmnvv7m 185 32 PK PK NNP cord-276616-odmnvv7m 185 33 . . . cord-276616-odmnvv7m 186 1 Lewin Lewin NNP cord-276616-odmnvv7m 186 2 ( ( -LRB- cord-276616-odmnvv7m 186 3 1982 1982 CD cord-276616-odmnvv7m 186 4 ) ) -RRB- cord-276616-odmnvv7m 186 5 was be VBD cord-276616-odmnvv7m 186 6 ready ready JJ cord-276616-odmnvv7m 186 7 to to TO cord-276616-odmnvv7m 186 8 accept accept VB cord-276616-odmnvv7m 186 9 that that IN cord-276616-odmnvv7m 186 10 the the DT cord-276616-odmnvv7m 186 11 prion prion NN cord-276616-odmnvv7m 186 12 is be VBZ cord-276616-odmnvv7m 186 13 involved involve VBN cord-276616-odmnvv7m 186 14 in in IN cord-276616-odmnvv7m 186 15 the the DT cord-276616-odmnvv7m 186 16 aetiology aetiology NN cord-276616-odmnvv7m 186 17 of of IN cord-276616-odmnvv7m 186 18 scrapie scrapie NN cord-276616-odmnvv7m 186 19 but but CC cord-276616-odmnvv7m 186 20 only only RB cord-276616-odmnvv7m 186 21 as as IN cord-276616-odmnvv7m 186 22 a a DT cord-276616-odmnvv7m 186 23 carrier carrier NN cord-276616-odmnvv7m 186 24 of of IN cord-276616-odmnvv7m 186 25 a a DT cord-276616-odmnvv7m 186 26 small small JJ cord-276616-odmnvv7m 186 27 protein protein NN cord-276616-odmnvv7m 186 28 or or CC cord-276616-odmnvv7m 186 29 peptide peptide NN cord-276616-odmnvv7m 186 30 that that IN cord-276616-odmnvv7m 186 31 he -PRON- PRP cord-276616-odmnvv7m 186 32 called call VBD cord-276616-odmnvv7m 186 33 a a DT cord-276616-odmnvv7m 186 34 protovirin protovirin NN cord-276616-odmnvv7m 186 35 . . . cord-276616-odmnvv7m 187 1 He -PRON- PRP cord-276616-odmnvv7m 187 2 suggested suggest VBD cord-276616-odmnvv7m 187 3 two two CD cord-276616-odmnvv7m 187 4 alternative alternative JJ cord-276616-odmnvv7m 187 5 mechanisms mechanism NNS cord-276616-odmnvv7m 187 6 by by IN cord-276616-odmnvv7m 187 7 which which WDT cord-276616-odmnvv7m 187 8 such such PDT cord-276616-odmnvv7m 187 9 an an DT cord-276616-odmnvv7m 187 10 entity entity NN cord-276616-odmnvv7m 187 11 could could MD cord-276616-odmnvv7m 187 12 act act VB cord-276616-odmnvv7m 187 13 either either CC cord-276616-odmnvv7m 187 14 as as IN cord-276616-odmnvv7m 187 15 an an DT cord-276616-odmnvv7m 187 16 RNA RNA NNP cord-276616-odmnvv7m 187 17 template template NN cord-276616-odmnvv7m 187 18 or or CC cord-276616-odmnvv7m 187 19 as as IN cord-276616-odmnvv7m 187 20 an an DT cord-276616-odmnvv7m 187 21 extraneous extraneous JJ cord-276616-odmnvv7m 187 22 DNA dna NN cord-276616-odmnvv7m 187 23 operon operon NN cord-276616-odmnvv7m 187 24 . . . cord-276616-odmnvv7m 188 1 It -PRON- PRP cord-276616-odmnvv7m 188 2 appears appear VBZ cord-276616-odmnvv7m 188 3 that that IN cord-276616-odmnvv7m 188 4 it -PRON- PRP cord-276616-odmnvv7m 188 5 is be VBZ cord-276616-odmnvv7m 188 6 very very RB cord-276616-odmnvv7m 188 7 difficult difficult JJ cord-276616-odmnvv7m 188 8 to to TO cord-276616-odmnvv7m 188 9 resolve resolve VB cord-276616-odmnvv7m 188 10 the the DT cord-276616-odmnvv7m 188 11 problems problem NNS cord-276616-odmnvv7m 188 12 of of IN cord-276616-odmnvv7m 188 13 whether whether IN cord-276616-odmnvv7m 188 14 PrPSc PrPSc NNP cord-276616-odmnvv7m 188 15 is be VBZ cord-276616-odmnvv7m 188 16 the the DT cord-276616-odmnvv7m 188 17 causal causal JJ cord-276616-odmnvv7m 188 18 agent agent NN cord-276616-odmnvv7m 188 19 of of IN cord-276616-odmnvv7m 188 20 scrapie scrapie NN cord-276616-odmnvv7m 188 21 or or CC cord-276616-odmnvv7m 188 22 a a DT cord-276616-odmnvv7m 188 23 carrier carrier NN cord-276616-odmnvv7m 188 24 agent agent NN cord-276616-odmnvv7m 188 25 , , , cord-276616-odmnvv7m 188 26 and and CC cord-276616-odmnvv7m 188 27 even even RB cord-276616-odmnvv7m 188 28 whether whether IN cord-276616-odmnvv7m 188 29 the the DT cord-276616-odmnvv7m 188 30 causal causal JJ cord-276616-odmnvv7m 188 31 agent agent NN cord-276616-odmnvv7m 188 32 is be VBZ cord-276616-odmnvv7m 188 33 a a DT cord-276616-odmnvv7m 188 34 protein protein NN cord-276616-odmnvv7m 188 35 , , , cord-276616-odmnvv7m 188 36 by by IN cord-276616-odmnvv7m 188 37 the the DT cord-276616-odmnvv7m 188 38 approaches approach NNS cord-276616-odmnvv7m 188 39 that that WDT cord-276616-odmnvv7m 188 40 have have VBP cord-276616-odmnvv7m 188 41 been be VBN cord-276616-odmnvv7m 188 42 so so RB cord-276616-odmnvv7m 188 43 far far RB cord-276616-odmnvv7m 188 44 made make VBN cord-276616-odmnvv7m 188 45 . . . cord-276616-odmnvv7m 189 1 Whatever whatever WDT cord-276616-odmnvv7m 189 2 the the DT cord-276616-odmnvv7m 189 3 outcome outcome NN cord-276616-odmnvv7m 189 4 , , , cord-276616-odmnvv7m 189 5 it -PRON- PRP cord-276616-odmnvv7m 189 6 is be VBZ cord-276616-odmnvv7m 189 7 certain certain JJ cord-276616-odmnvv7m 189 8 that that IN cord-276616-odmnvv7m 189 9 PrP prp NN cord-276616-odmnvv7m 189 10 plays play VBZ cord-276616-odmnvv7m 189 11 an an DT cord-276616-odmnvv7m 189 12 important important JJ cord-276616-odmnvv7m 189 13 part part NN cord-276616-odmnvv7m 189 14 in in IN cord-276616-odmnvv7m 189 15 the the DT cord-276616-odmnvv7m 189 16 pathogenesis pathogenesis NN cord-276616-odmnvv7m 189 17 of of IN cord-276616-odmnvv7m 189 18 the the DT cord-276616-odmnvv7m 189 19 transmissible transmissible JJ cord-276616-odmnvv7m 189 20 spongiform spongiform JJ cord-276616-odmnvv7m 189 21 encephalopathies encephalopathy NNS cord-276616-odmnvv7m 189 22 ( ( -LRB- cord-276616-odmnvv7m 189 23 Weissmann Weissmann NNP cord-276616-odmnvv7m 189 24 , , , cord-276616-odmnvv7m 189 25 1991a 1991a CD cord-276616-odmnvv7m 189 26 , , , cord-276616-odmnvv7m 189 27 b b LS cord-276616-odmnvv7m 189 28 ) ) -RRB- cord-276616-odmnvv7m 189 29 . . . cord-276616-odmnvv7m 190 1 The the DT cord-276616-odmnvv7m 190 2 discussion discussion NN cord-276616-odmnvv7m 190 3 on on IN cord-276616-odmnvv7m 190 4 the the DT cord-276616-odmnvv7m 190 5 role role NN cord-276616-odmnvv7m 190 6 of of IN cord-276616-odmnvv7m 190 7 prions prion NNS cord-276616-odmnvv7m 190 8 is be VBZ cord-276616-odmnvv7m 190 9 taken take VBN cord-276616-odmnvv7m 190 10 up up RP cord-276616-odmnvv7m 190 11 again again RB cord-276616-odmnvv7m 190 12 in in IN cord-276616-odmnvv7m 190 13 other other JJ cord-276616-odmnvv7m 190 14 sections section NNS cord-276616-odmnvv7m 190 15 of of IN cord-276616-odmnvv7m 190 16 this this DT cord-276616-odmnvv7m 190 17 paper paper NN cord-276616-odmnvv7m 190 18 . . . cord-276616-odmnvv7m 191 1 The the DT cord-276616-odmnvv7m 191 2 virino virino NN cord-276616-odmnvv7m 191 3 hypothesis hypothesis NN cord-276616-odmnvv7m 191 4 suggests suggest VBZ cord-276616-odmnvv7m 191 5 that that IN cord-276616-odmnvv7m 191 6 the the DT cord-276616-odmnvv7m 191 7 infectious infectious JJ cord-276616-odmnvv7m 191 8 agent agent NN cord-276616-odmnvv7m 191 9 of of IN cord-276616-odmnvv7m 191 10 scrapie scrapie NN cord-276616-odmnvv7m 191 11 is be VBZ cord-276616-odmnvv7m 191 12 a a DT cord-276616-odmnvv7m 191 13 very very RB cord-276616-odmnvv7m 191 14 small small JJ cord-276616-odmnvv7m 191 15 piece piece NN cord-276616-odmnvv7m 191 16 of of IN cord-276616-odmnvv7m 191 17 nucleic nucleic JJ cord-276616-odmnvv7m 191 18 acid acid NN cord-276616-odmnvv7m 191 19 with with IN cord-276616-odmnvv7m 191 20 a a DT cord-276616-odmnvv7m 191 21 behaviour behaviour NN cord-276616-odmnvv7m 191 22 intermediate intermediate JJ cord-276616-odmnvv7m 191 23 between between IN cord-276616-odmnvv7m 191 24 that that DT cord-276616-odmnvv7m 191 25 of of IN cord-276616-odmnvv7m 191 26 viruses virus NNS cord-276616-odmnvv7m 191 27 and and CC cord-276616-odmnvv7m 191 28 that that IN cord-276616-odmnvv7m 191 29 of of IN cord-276616-odmnvv7m 191 30 viroids viroid NNS cord-276616-odmnvv7m 191 31 ( ( -LRB- cord-276616-odmnvv7m 191 32 Dickinson Dickinson NNP cord-276616-odmnvv7m 191 33 and and CC cord-276616-odmnvv7m 191 34 Outram Outram NNP cord-276616-odmnvv7m 191 35 , , , cord-276616-odmnvv7m 191 36 1988 1988 CD cord-276616-odmnvv7m 191 37 ) ) -RRB- cord-276616-odmnvv7m 191 38 . . . cord-276616-odmnvv7m 192 1 It -PRON- PRP cord-276616-odmnvv7m 192 2 has have VBZ cord-276616-odmnvv7m 192 3 been be VBN cord-276616-odmnvv7m 192 4 further further RB cord-276616-odmnvv7m 192 5 suggested suggest VBN cord-276616-odmnvv7m 192 6 that that IN cord-276616-odmnvv7m 192 7 the the DT cord-276616-odmnvv7m 192 8 virino virino NN cord-276616-odmnvv7m 192 9 is be VBZ cord-276616-odmnvv7m 192 10 not not RB cord-276616-odmnvv7m 192 11 translated translate VBN cord-276616-odmnvv7m 192 12 and and CC cord-276616-odmnvv7m 192 13 is be VBZ cord-276616-odmnvv7m 192 14 therefore therefore RB cord-276616-odmnvv7m 192 15 dependent dependent JJ cord-276616-odmnvv7m 192 16 on on IN cord-276616-odmnvv7m 192 17 host host NN cord-276616-odmnvv7m 192 18 - - HYPH cord-276616-odmnvv7m 192 19 coded code VBN cord-276616-odmnvv7m 192 20 protein protein NN cord-276616-odmnvv7m 192 21 to to TO cord-276616-odmnvv7m 192 22 form form VB cord-276616-odmnvv7m 192 23 an an DT cord-276616-odmnvv7m 192 24 infectious infectious JJ cord-276616-odmnvv7m 192 25 unit unit NN cord-276616-odmnvv7m 192 26 ( ( -LRB- cord-276616-odmnvv7m 192 27 Kimberlin Kimberlin NNP cord-276616-odmnvv7m 192 28 , , , cord-276616-odmnvv7m 192 29 1990 1990 CD cord-276616-odmnvv7m 192 30 ) ) -RRB- cord-276616-odmnvv7m 192 31 . . . cord-276616-odmnvv7m 193 1 With with IN cord-276616-odmnvv7m 193 2 the the DT cord-276616-odmnvv7m 193 3 nucleic nucleic JJ cord-276616-odmnvv7m 193 4 acid acid NN cord-276616-odmnvv7m 193 5 probe probe NN cord-276616-odmnvv7m 193 6 techniques technique NNS cord-276616-odmnvv7m 193 7 now now RB cord-276616-odmnvv7m 193 8 available available JJ cord-276616-odmnvv7m 193 9 , , , cord-276616-odmnvv7m 193 10 it -PRON- PRP cord-276616-odmnvv7m 193 11 would would MD cord-276616-odmnvv7m 193 12 be be VB cord-276616-odmnvv7m 193 13 thought think VBN cord-276616-odmnvv7m 193 14 that that IN cord-276616-odmnvv7m 193 15 virinos virinos NNP cord-276616-odmnvv7m 193 16 would would MD cord-276616-odmnvv7m 193 17 be be VB cord-276616-odmnvv7m 193 18 detectable detectable JJ cord-276616-odmnvv7m 193 19 if if IN cord-276616-odmnvv7m 193 20 they -PRON- PRP cord-276616-odmnvv7m 193 21 exist exist VBP cord-276616-odmnvv7m 193 22 , , , cord-276616-odmnvv7m 193 23 but but CC cord-276616-odmnvv7m 193 24 no no DT cord-276616-odmnvv7m 193 25 report report NN cord-276616-odmnvv7m 193 26 of of IN cord-276616-odmnvv7m 193 27 such such JJ cord-276616-odmnvv7m 193 28 work work NN cord-276616-odmnvv7m 193 29 has have VBZ cord-276616-odmnvv7m 193 30 yet yet RB cord-276616-odmnvv7m 193 31 appeared appear VBN cord-276616-odmnvv7m 193 32 . . . cord-276616-odmnvv7m 194 1 Characteristic characteristic JJ cord-276616-odmnvv7m 194 2 features feature NNS cord-276616-odmnvv7m 194 3 of of IN cord-276616-odmnvv7m 194 4 spongiform spongiform JJ cord-276616-odmnvv7m 194 5 encephalopathies encephalopathy NNS cord-276616-odmnvv7m 194 6 include include VBP cord-276616-odmnvv7m 194 7 their -PRON- PRP$ cord-276616-odmnvv7m 194 8 long long JJ cord-276616-odmnvv7m 194 9 latent latent JJ cord-276616-odmnvv7m 194 10 period period NN cord-276616-odmnvv7m 194 11 for for IN cord-276616-odmnvv7m 194 12 development development NN cord-276616-odmnvv7m 194 13 of of IN cord-276616-odmnvv7m 194 14 overt overt JJ cord-276616-odmnvv7m 194 15 disease disease NN cord-276616-odmnvv7m 194 16 and and CC cord-276616-odmnvv7m 194 17 the the DT cord-276616-odmnvv7m 194 18 need need NN cord-276616-odmnvv7m 194 19 for for IN cord-276616-odmnvv7m 194 20 the the DT cord-276616-odmnvv7m 194 21 presence presence NN cord-276616-odmnvv7m 194 22 of of IN cord-276616-odmnvv7m 194 23 ' ' `` cord-276616-odmnvv7m 194 24 susceptibility susceptibility NN cord-276616-odmnvv7m 194 25 ' ' '' cord-276616-odmnvv7m 194 26 genes gene NNS cord-276616-odmnvv7m 194 27 and and CC cord-276616-odmnvv7m 194 28 the the DT cord-276616-odmnvv7m 194 29 PrP prp NN cord-276616-odmnvv7m 194 30 gene gene NN cord-276616-odmnvv7m 194 31 in in IN cord-276616-odmnvv7m 194 32 the the DT cord-276616-odmnvv7m 194 33 prospective prospective JJ cord-276616-odmnvv7m 194 34 host host NN cord-276616-odmnvv7m 194 35 . . . cord-276616-odmnvv7m 195 1 This this DT cord-276616-odmnvv7m 195 2 does do VBZ cord-276616-odmnvv7m 195 3 not not RB cord-276616-odmnvv7m 195 4 rule rule VB cord-276616-odmnvv7m 195 5 out out RP cord-276616-odmnvv7m 195 6 the the DT cord-276616-odmnvv7m 195 7 involvement involvement NN cord-276616-odmnvv7m 195 8 of of IN cord-276616-odmnvv7m 195 9 a a DT cord-276616-odmnvv7m 195 10 conventional conventional JJ cord-276616-odmnvv7m 195 11 virus virus NN cord-276616-odmnvv7m 195 12 in in IN cord-276616-odmnvv7m 195 13 causation causation NN cord-276616-odmnvv7m 195 14 of of IN cord-276616-odmnvv7m 195 15 these these DT cord-276616-odmnvv7m 195 16 diseases disease NNS cord-276616-odmnvv7m 195 17 . . . cord-276616-odmnvv7m 196 1 Although although IN cord-276616-odmnvv7m 196 2 no no DT cord-276616-odmnvv7m 196 3 such such JJ cord-276616-odmnvv7m 196 4 virus virus NN cord-276616-odmnvv7m 196 5 has have VBZ cord-276616-odmnvv7m 196 6 yet yet RB cord-276616-odmnvv7m 196 7 been be VBN cord-276616-odmnvv7m 196 8 demonstrated demonstrate VBN cord-276616-odmnvv7m 196 9 in in IN cord-276616-odmnvv7m 196 10 infective infective JJ cord-276616-odmnvv7m 196 11 extracts extract NNS cord-276616-odmnvv7m 196 12 , , , cord-276616-odmnvv7m 196 13 many many JJ cord-276616-odmnvv7m 196 14 believe believe VBP cord-276616-odmnvv7m 196 15 that that IN cord-276616-odmnvv7m 196 16 such such JJ cord-276616-odmnvv7m 196 17 viruses virus NNS cord-276616-odmnvv7m 196 18 may may MD cord-276616-odmnvv7m 196 19 be be VB cord-276616-odmnvv7m 196 20 involved involve VBN cord-276616-odmnvv7m 196 21 . . . cord-276616-odmnvv7m 197 1 Chesebro Chesebro NNP cord-276616-odmnvv7m 197 2 ( ( -LRB- cord-276616-odmnvv7m 197 3 1992 1992 CD cord-276616-odmnvv7m 197 4 ) ) -RRB- cord-276616-odmnvv7m 197 5 , , , cord-276616-odmnvv7m 197 6 reviewing review VBG cord-276616-odmnvv7m 197 7 the the DT cord-276616-odmnvv7m 197 8 role role NN cord-276616-odmnvv7m 197 9 of of IN cord-276616-odmnvv7m 197 10 PrP prp NN cord-276616-odmnvv7m 197 11 in in IN cord-276616-odmnvv7m 197 12 the the DT cord-276616-odmnvv7m 197 13 aetiology aetiology NN cord-276616-odmnvv7m 197 14 of of IN cord-276616-odmnvv7m 197 15 scrapie scrapie NN cord-276616-odmnvv7m 197 16 , , , cord-276616-odmnvv7m 197 17 raised raise VBD cord-276616-odmnvv7m 197 18 the the DT cord-276616-odmnvv7m 197 19 possibility possibility NN cord-276616-odmnvv7m 197 20 that that IN cord-276616-odmnvv7m 197 21 a a DT cord-276616-odmnvv7m 197 22 mutation mutation NN cord-276616-odmnvv7m 197 23 of of IN cord-276616-odmnvv7m 197 24 this this DT cord-276616-odmnvv7m 197 25 gene gene NN cord-276616-odmnvv7m 197 26 increases increase VBZ cord-276616-odmnvv7m 197 27 the the DT cord-276616-odmnvv7m 197 28 susceptibility susceptibility NN cord-276616-odmnvv7m 197 29 to to IN cord-276616-odmnvv7m 197 30 an an DT cord-276616-odmnvv7m 197 31 unknown unknown JJ cord-276616-odmnvv7m 197 32 but but CC cord-276616-odmnvv7m 197 33 ubiquitous ubiquitous JJ cord-276616-odmnvv7m 197 34 conventional conventional JJ cord-276616-odmnvv7m 197 35 virus virus NN cord-276616-odmnvv7m 197 36 . . . cord-276616-odmnvv7m 198 1 Rohwer Rohwer NNP cord-276616-odmnvv7m 198 2 ( ( -LRB- cord-276616-odmnvv7m 198 3 1991 1991 CD cord-276616-odmnvv7m 198 4 ) ) -RRB- cord-276616-odmnvv7m 198 5 summarized summarize VBD cord-276616-odmnvv7m 198 6 in in IN cord-276616-odmnvv7m 198 7 a a DT cord-276616-odmnvv7m 198 8 masterful masterful JJ cord-276616-odmnvv7m 198 9 way way NN cord-276616-odmnvv7m 198 10 why why WRB cord-276616-odmnvv7m 198 11 conventional conventional JJ cord-276616-odmnvv7m 198 12 viruses virus NNS cord-276616-odmnvv7m 198 13 may may MD cord-276616-odmnvv7m 198 14 still still RB cord-276616-odmnvv7m 198 15 be be VB cord-276616-odmnvv7m 198 16 the the DT cord-276616-odmnvv7m 198 17 most most RBS cord-276616-odmnvv7m 198 18 likely likely JJ cord-276616-odmnvv7m 198 19 causes cause NNS cord-276616-odmnvv7m 198 20 of of IN cord-276616-odmnvv7m 198 21 the the DT cord-276616-odmnvv7m 198 22 spongiform spongiform JJ cord-276616-odmnvv7m 198 23 encephalopathies encephalopathy NNS cord-276616-odmnvv7m 198 24 . . . cord-276616-odmnvv7m 199 1 For for IN cord-276616-odmnvv7m 199 2 example example NN cord-276616-odmnvv7m 199 3 , , , cord-276616-odmnvv7m 199 4 the the DT cord-276616-odmnvv7m 199 5 long long JJ cord-276616-odmnvv7m 199 6 latent latent JJ cord-276616-odmnvv7m 199 7 period period NN cord-276616-odmnvv7m 199 8 needed need VBN cord-276616-odmnvv7m 199 9 for for IN cord-276616-odmnvv7m 199 10 the the DT cord-276616-odmnvv7m 199 11 spongiform spongiform JJ cord-276616-odmnvv7m 199 12 encephalopathies encephalopathy NNS cord-276616-odmnvv7m 199 13 to to TO cord-276616-odmnvv7m 199 14 develop develop VB cord-276616-odmnvv7m 199 15 is be VBZ cord-276616-odmnvv7m 199 16 similar similar JJ cord-276616-odmnvv7m 199 17 to to IN cord-276616-odmnvv7m 199 18 the the DT cord-276616-odmnvv7m 199 19 length length NN cord-276616-odmnvv7m 199 20 of of IN cord-276616-odmnvv7m 199 21 time time NN cord-276616-odmnvv7m 199 22 often often RB cord-276616-odmnvv7m 199 23 required require VBN cord-276616-odmnvv7m 199 24 by by IN cord-276616-odmnvv7m 199 25 lentiviruses lentiviruse NNS cord-276616-odmnvv7m 199 26 such such JJ cord-276616-odmnvv7m 199 27 as as IN cord-276616-odmnvv7m 199 28 the the DT cord-276616-odmnvv7m 199 29 maedi maedi NNP cord-276616-odmnvv7m 199 30 - - HYPH cord-276616-odmnvv7m 199 31 visna visna NN cord-276616-odmnvv7m 199 32 virus virus NN cord-276616-odmnvv7m 199 33 of of IN cord-276616-odmnvv7m 199 34 sheep sheep NN cord-276616-odmnvv7m 199 35 . . . cord-276616-odmnvv7m 200 1 However however RB cord-276616-odmnvv7m 200 2 , , , cord-276616-odmnvv7m 200 3 no no DT cord-276616-odmnvv7m 200 4 connection connection NN cord-276616-odmnvv7m 200 5 has have VBZ cord-276616-odmnvv7m 200 6 been be VBN cord-276616-odmnvv7m 200 7 made make VBN cord-276616-odmnvv7m 200 8 between between IN cord-276616-odmnvv7m 200 9 such such JJ cord-276616-odmnvv7m 200 10 viruses virus NNS cord-276616-odmnvv7m 200 11 and and CC cord-276616-odmnvv7m 200 12 scrapie scrapie NN cord-276616-odmnvv7m 200 13 . . . cord-276616-odmnvv7m 201 1 A a DT cord-276616-odmnvv7m 201 2 long long JJ cord-276616-odmnvv7m 201 3 latent latent JJ cord-276616-odmnvv7m 201 4 period period NN cord-276616-odmnvv7m 201 5 for for IN cord-276616-odmnvv7m 201 6 disease disease NN cord-276616-odmnvv7m 201 7 to to TO cord-276616-odmnvv7m 201 8 develop develop VB cord-276616-odmnvv7m 201 9 is be VBZ cord-276616-odmnvv7m 201 10 seen see VBN cord-276616-odmnvv7m 201 11 with with IN cord-276616-odmnvv7m 201 12 other other JJ cord-276616-odmnvv7m 201 13 viruses virus NNS cord-276616-odmnvv7m 201 14 , , , cord-276616-odmnvv7m 201 15 for for IN cord-276616-odmnvv7m 201 16 example example NN cord-276616-odmnvv7m 201 17 oncornaviruses oncornaviruse NNS cord-276616-odmnvv7m 201 18 . . . cord-276616-odmnvv7m 202 1 Examples example NNS cord-276616-odmnvv7m 202 2 are be VBP cord-276616-odmnvv7m 202 3 the the DT cord-276616-odmnvv7m 202 4 lymphoid lymphoid NNP cord-276616-odmnvv7m 202 5 leukosis leukosis NN cord-276616-odmnvv7m 202 6 viruses virus NNS cord-276616-odmnvv7m 202 7 of of IN cord-276616-odmnvv7m 202 8 chickens chicken NNS cord-276616-odmnvv7m 202 9 ; ; : cord-276616-odmnvv7m 202 10 these these DT cord-276616-odmnvv7m 202 11 are be VBP cord-276616-odmnvv7m 202 12 noted note VBN cord-276616-odmnvv7m 202 13 for for IN cord-276616-odmnvv7m 202 14 their -PRON- PRP$ cord-276616-odmnvv7m 202 15 ability ability NN cord-276616-odmnvv7m 202 16 to to TO cord-276616-odmnvv7m 202 17 activate activate VB cord-276616-odmnvv7m 202 18 the the DT cord-276616-odmnvv7m 202 19 formation formation NN cord-276616-odmnvv7m 202 20 of of IN cord-276616-odmnvv7m 202 21 oncogenes oncogene NNS cord-276616-odmnvv7m 202 22 . . . cord-276616-odmnvv7m 203 1 Oncogenes oncogene NNS cord-276616-odmnvv7m 203 2 are be VBP cord-276616-odmnvv7m 203 3 involved involve VBN cord-276616-odmnvv7m 203 4 in in IN cord-276616-odmnvv7m 203 5 turnout turnout NN cord-276616-odmnvv7m 203 6 formation formation NN cord-276616-odmnvv7m 203 7 because because IN cord-276616-odmnvv7m 203 8 their -PRON- PRP$ cord-276616-odmnvv7m 203 9 presence presence NN cord-276616-odmnvv7m 203 10 leads lead VBZ cord-276616-odmnvv7m 203 11 to to IN cord-276616-odmnvv7m 203 12 perturbation perturbation NN cord-276616-odmnvv7m 203 13 of of IN cord-276616-odmnvv7m 203 14 the the DT cord-276616-odmnvv7m 203 15 normal normal JJ cord-276616-odmnvv7m 203 16 cell cell NN cord-276616-odmnvv7m 203 17 physiology physiology NN cord-276616-odmnvv7m 203 18 . . . cord-276616-odmnvv7m 204 1 Scrapie Scrapie NNP cord-276616-odmnvv7m 204 2 is be VBZ cord-276616-odmnvv7m 204 3 not not RB cord-276616-odmnvv7m 204 4 characterized characterize VBN cord-276616-odmnvv7m 204 5 by by IN cord-276616-odmnvv7m 204 6 the the DT cord-276616-odmnvv7m 204 7 development development NN cord-276616-odmnvv7m 204 8 of of IN cord-276616-odmnvv7m 204 9 tumours tumour NNS cord-276616-odmnvv7m 204 10 but but CC cord-276616-odmnvv7m 204 11 oncogenes oncogene NNS cord-276616-odmnvv7m 204 12 could could MD cord-276616-odmnvv7m 204 13 still still RB cord-276616-odmnvv7m 204 14 be be VB cord-276616-odmnvv7m 204 15 involved involve VBN cord-276616-odmnvv7m 204 16 , , , cord-276616-odmnvv7m 204 17 tied tie VBN cord-276616-odmnvv7m 204 18 as as IN cord-276616-odmnvv7m 204 19 they -PRON- PRP cord-276616-odmnvv7m 204 20 are be VBP cord-276616-odmnvv7m 204 21 to to IN cord-276616-odmnvv7m 204 22 normal normal JJ cord-276616-odmnvv7m 204 23 cell cell NN cord-276616-odmnvv7m 204 24 physiology physiology NN cord-276616-odmnvv7m 204 25 and and CC cord-276616-odmnvv7m 204 26 to to TO cord-276616-odmnvv7m 204 27 gene gene NN cord-276616-odmnvv7m 204 28 changes change NNS cord-276616-odmnvv7m 204 29 . . . cord-276616-odmnvv7m 205 1 Studies study NNS cord-276616-odmnvv7m 205 2 similar similar JJ cord-276616-odmnvv7m 205 3 to to IN cord-276616-odmnvv7m 205 4 those those DT cord-276616-odmnvv7m 205 5 now now RB cord-276616-odmnvv7m 205 6 being be VBG cord-276616-odmnvv7m 205 7 made make VBN cord-276616-odmnvv7m 205 8 in in IN cord-276616-odmnvv7m 205 9 oncology oncology NN cord-276616-odmnvv7m 205 10 might may MD cord-276616-odmnvv7m 205 11 be be VB cord-276616-odmnvv7m 205 12 most most RBS cord-276616-odmnvv7m 205 13 fruitful fruitful JJ cord-276616-odmnvv7m 205 14 . . . cord-276616-odmnvv7m 206 1 References reference NNS cord-276616-odmnvv7m 206 2 should should MD cord-276616-odmnvv7m 206 3 be be VB cord-276616-odmnvv7m 206 4 made make VBN cord-276616-odmnvv7m 206 5 to to IN cord-276616-odmnvv7m 206 6 oncogenes oncogene NNS cord-276616-odmnvv7m 206 7 in in IN cord-276616-odmnvv7m 206 8 the the DT cord-276616-odmnvv7m 206 9 human human JJ cord-276616-odmnvv7m 206 10 genome genome NN cord-276616-odmnvv7m 206 11 , , , cord-276616-odmnvv7m 206 12 where where WRB cord-276616-odmnvv7m 206 13 as as RB cord-276616-odmnvv7m 206 14 much much JJ cord-276616-odmnvv7m 206 15 as as IN cord-276616-odmnvv7m 206 16 0.1 0.1 CD cord-276616-odmnvv7m 206 17 - - SYM cord-276616-odmnvv7m 206 18 0.6 0.6 CD cord-276616-odmnvv7m 206 19 % % NN cord-276616-odmnvv7m 206 20 may may MD cord-276616-odmnvv7m 206 21 be be VB cord-276616-odmnvv7m 206 22 derived derive VBN cord-276616-odmnvv7m 206 23 from from IN cord-276616-odmnvv7m 206 24 endogenous endogenous JJ cord-276616-odmnvv7m 206 25 sequences sequence NNS cord-276616-odmnvv7m 206 26 . . . cord-276616-odmnvv7m 207 1 One one CD cord-276616-odmnvv7m 207 2 such such JJ cord-276616-odmnvv7m 207 3 sequence sequence NN cord-276616-odmnvv7m 207 4 is be VBZ cord-276616-odmnvv7m 207 5 the the DT cord-276616-odmnvv7m 207 6 ERV-3 ERV-3 NNP cord-276616-odmnvv7m 207 7 virus virus NN cord-276616-odmnvv7m 207 8 , , , cord-276616-odmnvv7m 207 9 first first RB cord-276616-odmnvv7m 207 10 recognized recognize VBN cord-276616-odmnvv7m 207 11 by by IN cord-276616-odmnvv7m 207 12 low low JJ cord-276616-odmnvv7m 207 13 - - HYPH cord-276616-odmnvv7m 207 14 stringency stringency NN cord-276616-odmnvv7m 207 15 hybridization hybridization NN cord-276616-odmnvv7m 207 16 to to IN cord-276616-odmnvv7m 207 17 probes probe NNS cord-276616-odmnvv7m 207 18 derived derive VBN cord-276616-odmnvv7m 207 19 from from IN cord-276616-odmnvv7m 207 20 the the DT cord-276616-odmnvv7m 207 21 pol pol NN cord-276616-odmnvv7m 207 22 region region NN cord-276616-odmnvv7m 207 23 of of IN cord-276616-odmnvv7m 207 24 the the DT cord-276616-odmnvv7m 207 25 chimpanzee chimpanzee NN cord-276616-odmnvv7m 207 26 CH2 ch2 NN cord-276616-odmnvv7m 207 27 endogenous endogenous JJ cord-276616-odmnvv7m 207 28 provirus provirus NNP cord-276616-odmnvv7m 208 1 ( ( -LRB- cord-276616-odmnvv7m 208 2 Boyd Boyd NNP cord-276616-odmnvv7m 208 3 et et NNP cord-276616-odmnvv7m 208 4 al al NNP cord-276616-odmnvv7m 208 5 . . NNP cord-276616-odmnvv7m 208 6 , , , cord-276616-odmnvv7m 208 7 1993 1993 CD cord-276616-odmnvv7m 208 8 ) ) -RRB- cord-276616-odmnvv7m 208 9 . . . cord-276616-odmnvv7m 209 1 This this DT cord-276616-odmnvv7m 209 2 work work NN cord-276616-odmnvv7m 209 3 is be VBZ cord-276616-odmnvv7m 209 4 mentioned mention VBN cord-276616-odmnvv7m 209 5 as as IN cord-276616-odmnvv7m 209 6 being be VBG cord-276616-odmnvv7m 209 7 indicative indicative JJ cord-276616-odmnvv7m 209 8 of of IN cord-276616-odmnvv7m 209 9 a a DT cord-276616-odmnvv7m 209 10 type type NN cord-276616-odmnvv7m 209 11 of of IN cord-276616-odmnvv7m 209 12 approach approach NN cord-276616-odmnvv7m 209 13 that that WDT cord-276616-odmnvv7m 209 14 should should MD cord-276616-odmnvv7m 209 15 be be VB cord-276616-odmnvv7m 209 16 undertaken undertake VBN cord-276616-odmnvv7m 209 17 on on IN cord-276616-odmnvv7m 209 18 a a DT cord-276616-odmnvv7m 209 19 major major JJ cord-276616-odmnvv7m 209 20 scale scale NN cord-276616-odmnvv7m 209 21 with with IN cord-276616-odmnvv7m 209 22 bovine bovine JJ cord-276616-odmnvv7m 209 23 and and CC cord-276616-odmnvv7m 209 24 ovine ovine JJ cord-276616-odmnvv7m 209 25 tissues tissue NNS cord-276616-odmnvv7m 209 26 . . . cord-276616-odmnvv7m 210 1 Particular particular JJ cord-276616-odmnvv7m 210 2 attention attention NN cord-276616-odmnvv7m 210 3 should should MD cord-276616-odmnvv7m 210 4 be be VB cord-276616-odmnvv7m 210 5 paid pay VBN cord-276616-odmnvv7m 210 6 to to IN cord-276616-odmnvv7m 210 7 the the DT cord-276616-odmnvv7m 210 8 possibility possibility NN cord-276616-odmnvv7m 210 9 of of IN cord-276616-odmnvv7m 210 10 retroviruses retrovirus NNS cord-276616-odmnvv7m 210 11 akin akin JJ cord-276616-odmnvv7m 210 12 to to IN cord-276616-odmnvv7m 210 13 the the DT cord-276616-odmnvv7m 210 14 mink mink NN cord-276616-odmnvv7m 210 15 - - HYPH cord-276616-odmnvv7m 210 16 cell cell NN cord-276616-odmnvv7m 210 17 focus focus NN cord-276616-odmnvv7m 210 18 ( ( -LRB- cord-276616-odmnvv7m 210 19 MCF MCF NNP cord-276616-odmnvv7m 210 20 ) ) -RRB- cord-276616-odmnvv7m 210 21 inducing induce VBG cord-276616-odmnvv7m 210 22 viruses virus NNS cord-276616-odmnvv7m 210 23 being be VBG cord-276616-odmnvv7m 210 24 involved involve VBN cord-276616-odmnvv7m 210 25 in in IN cord-276616-odmnvv7m 210 26 the the DT cord-276616-odmnvv7m 210 27 pathogenesis pathogenesis NN cord-276616-odmnvv7m 210 28 of of IN cord-276616-odmnvv7m 210 29 the the DT cord-276616-odmnvv7m 210 30 spongiform spongiform NN cord-276616-odmnvv7m 210 31 encephalopathies encephalopathies NNP cord-276616-odmnvv7m 210 32 5 5 CD cord-276616-odmnvv7m 210 33 . . . cord-276616-odmnvv7m 211 1 The the DT cord-276616-odmnvv7m 211 2 possible possible JJ cord-276616-odmnvv7m 211 3 involvement involvement NN cord-276616-odmnvv7m 211 4 of of IN cord-276616-odmnvv7m 211 5 other other JJ cord-276616-odmnvv7m 211 6 retroviruses retrovirus NNS cord-276616-odmnvv7m 211 7 , , , cord-276616-odmnvv7m 211 8 particularly particularly RB cord-276616-odmnvv7m 211 9 the the DT cord-276616-odmnvv7m 211 10 lentiviruses lentiviruse NNS cord-276616-odmnvv7m 211 11 , , , cord-276616-odmnvv7m 211 12 maedi maedi JJ cord-276616-odmnvv7m 211 13 - - HYPH cord-276616-odmnvv7m 211 14 visna visna NNS cord-276616-odmnvv7m 211 15 in in IN cord-276616-odmnvv7m 211 16 sheep sheep NN cord-276616-odmnvv7m 211 17 and and CC cord-276616-odmnvv7m 211 18 visna visna NN cord-276616-odmnvv7m 211 19 - - HYPH cord-276616-odmnvv7m 211 20 like like JJ cord-276616-odmnvv7m 211 21 virus virus NN cord-276616-odmnvv7m 211 22 in in IN cord-276616-odmnvv7m 211 23 cattle cattle NNS cord-276616-odmnvv7m 211 24 ( ( -LRB- cord-276616-odmnvv7m 211 25 Evermann Evermann NNP cord-276616-odmnvv7m 211 26 , , , cord-276616-odmnvv7m 211 27 1990 1990 CD cord-276616-odmnvv7m 211 28 ) ) -RRB- cord-276616-odmnvv7m 211 29 should should MD cord-276616-odmnvv7m 211 30 not not RB cord-276616-odmnvv7m 211 31 be be VB cord-276616-odmnvv7m 211 32 overlooked overlook VBN cord-276616-odmnvv7m 211 33 as as IN cord-276616-odmnvv7m 211 34 possible possible JJ cord-276616-odmnvv7m 211 35 contributors contributor NNS cord-276616-odmnvv7m 211 36 to to IN cord-276616-odmnvv7m 211 37 the the DT cord-276616-odmnvv7m 211 38 development development NN cord-276616-odmnvv7m 211 39 of of IN cord-276616-odmnvv7m 211 40 scrapie scrapie NN cord-276616-odmnvv7m 211 41 and and CC cord-276616-odmnvv7m 211 42 BSE BSE NNP cord-276616-odmnvv7m 211 43 , , , cord-276616-odmnvv7m 211 44 in in IN cord-276616-odmnvv7m 211 45 their -PRON- PRP$ cord-276616-odmnvv7m 211 46 respective respective JJ cord-276616-odmnvv7m 211 47 hosts host NNS cord-276616-odmnvv7m 211 48 . . . cord-276616-odmnvv7m 212 1 Attention attention NN cord-276616-odmnvv7m 212 2 is be VBZ cord-276616-odmnvv7m 212 3 also also RB cord-276616-odmnvv7m 212 4 drawn draw VBN cord-276616-odmnvv7m 212 5 to to IN cord-276616-odmnvv7m 212 6 the the DT cord-276616-odmnvv7m 212 7 mouse mouse NN cord-276616-odmnvv7m 212 8 hepatitis hepatitis NN cord-276616-odmnvv7m 212 9 viruses virus NNS cord-276616-odmnvv7m 212 10 , , , cord-276616-odmnvv7m 212 11 coronaviruses coronaviruse NNS cord-276616-odmnvv7m 212 12 that that WDT cord-276616-odmnvv7m 212 13 have have VBP cord-276616-odmnvv7m 212 14 the the DT cord-276616-odmnvv7m 212 15 ability ability NN cord-276616-odmnvv7m 212 16 to to TO cord-276616-odmnvv7m 212 17 enter enter VB cord-276616-odmnvv7m 212 18 into into IN cord-276616-odmnvv7m 212 19 recombination recombination NN cord-276616-odmnvv7m 212 20 with with IN cord-276616-odmnvv7m 212 21 other other JJ cord-276616-odmnvv7m 212 22 viruses virus NNS cord-276616-odmnvv7m 213 1 ( ( -LRB- cord-276616-odmnvv7m 213 2 Luytes Luytes NNP cord-276616-odmnvv7m 213 3 et et NNP cord-276616-odmnvv7m 213 4 al al NNP cord-276616-odmnvv7m 213 5 . . . cord-276616-odmnvv7m 214 1 , , , cord-276616-odmnvv7m 214 2 1988 1988 CD cord-276616-odmnvv7m 214 3 ) ) -RRB- cord-276616-odmnvv7m 214 4 and and CC cord-276616-odmnvv7m 214 5 are be VBP cord-276616-odmnvv7m 214 6 widely widely RB cord-276616-odmnvv7m 214 7 present present JJ cord-276616-odmnvv7m 214 8 in in IN cord-276616-odmnvv7m 214 9 mouse mouse NN cord-276616-odmnvv7m 214 10 stocks stock NNS cord-276616-odmnvv7m 214 11 ; ; : cord-276616-odmnvv7m 214 12 there there EX cord-276616-odmnvv7m 214 13 are be VBP cord-276616-odmnvv7m 214 14 also also RB cord-276616-odmnvv7m 214 15 neurotropic neurotropic JJ cord-276616-odmnvv7m 214 16 strains strain NNS cord-276616-odmnvv7m 214 17 ( ( -LRB- cord-276616-odmnvv7m 214 18 Kyuwa Kyuwa NNP cord-276616-odmnvv7m 214 19 and and CC cord-276616-odmnvv7m 214 20 Stohlman Stohlman NNP cord-276616-odmnvv7m 214 21 , , , cord-276616-odmnvv7m 214 22 1990 1990 CD cord-276616-odmnvv7m 214 23 ) ) -RRB- cord-276616-odmnvv7m 214 24 . . . cord-276616-odmnvv7m 215 1 Louping loupe VBG cord-276616-odmnvv7m 215 2 - - HYPH cord-276616-odmnvv7m 215 3 ill ill JJ cord-276616-odmnvv7m 215 4 virus virus NN cord-276616-odmnvv7m 215 5 is be VBZ cord-276616-odmnvv7m 215 6 a a DT cord-276616-odmnvv7m 215 7 tick tick VB cord-276616-odmnvv7m 215 8 - - HYPH cord-276616-odmnvv7m 215 9 transmitted transmit VBN cord-276616-odmnvv7m 215 10 member member NN cord-276616-odmnvv7m 215 11 of of IN cord-276616-odmnvv7m 215 12 the the DT cord-276616-odmnvv7m 215 13 virus virus NN cord-276616-odmnvv7m 215 14 family family NN cord-276616-odmnvv7m 215 15 Flaviviridae Flaviviridae NNP cord-276616-odmnvv7m 215 16 ( ( -LRB- cord-276616-odmnvv7m 216 1 Fenner Fenner NNP cord-276616-odmnvv7m 216 2 et et NNP cord-276616-odmnvv7m 216 3 al al NNP cord-276616-odmnvv7m 216 4 . . NNP cord-276616-odmnvv7m 216 5 , , , cord-276616-odmnvv7m 216 6 1987 1987 CD cord-276616-odmnvv7m 217 1 ; ; : cord-276616-odmnvv7m 217 2 Gao Gao NNP cord-276616-odmnvv7m 217 3 et et NNP cord-276616-odmnvv7m 217 4 al al NNP cord-276616-odmnvv7m 217 5 . . NNP cord-276616-odmnvv7m 217 6 , , , cord-276616-odmnvv7m 217 7 1993 1993 CD cord-276616-odmnvv7m 217 8 ) ) -RRB- cord-276616-odmnvv7m 217 9 that that WDT cord-276616-odmnvv7m 217 10 is be VBZ cord-276616-odmnvv7m 217 11 closely closely RB cord-276616-odmnvv7m 217 12 related relate VBN cord-276616-odmnvv7m 217 13 to to IN cord-276616-odmnvv7m 217 14 other other JJ cord-276616-odmnvv7m 217 15 European european JJ cord-276616-odmnvv7m 217 16 tick tick NN cord-276616-odmnvv7m 217 17 - - HYPH cord-276616-odmnvv7m 217 18 borne bear VBN cord-276616-odmnvv7m 217 19 encephalitis encephalitis NN cord-276616-odmnvv7m 217 20 viruses virus NNS cord-276616-odmnvv7m 218 1 ( ( -LRB- cord-276616-odmnvv7m 218 2 Jiaug Jiaug NNP cord-276616-odmnvv7m 218 3 et et FW cord-276616-odmnvv7m 218 4 al al NNP cord-276616-odmnvv7m 218 5 . . NNP cord-276616-odmnvv7m 218 6 , , , cord-276616-odmnvv7m 218 7 1993 1993 CD cord-276616-odmnvv7m 218 8 ) ) -RRB- cord-276616-odmnvv7m 218 9 . . . cord-276616-odmnvv7m 219 1 It -PRON- PRP cord-276616-odmnvv7m 219 2 was be VBD cord-276616-odmnvv7m 219 3 the the DT cord-276616-odmnvv7m 219 4 evaluation evaluation NN cord-276616-odmnvv7m 219 5 of of IN cord-276616-odmnvv7m 219 6 a a DT cord-276616-odmnvv7m 219 7 vaccine vaccine NN cord-276616-odmnvv7m 219 8 designed design VBN cord-276616-odmnvv7m 219 9 to to TO cord-276616-odmnvv7m 219 10 prevent prevent VB cord-276616-odmnvv7m 219 11 disease disease NN cord-276616-odmnvv7m 219 12 due due JJ cord-276616-odmnvv7m 219 13 to to IN cord-276616-odmnvv7m 219 14 louping louping NN cord-276616-odmnvv7m 219 15 - - HYPH cord-276616-odmnvv7m 219 16 ill ill JJ cord-276616-odmnvv7m 219 17 that that WDT cord-276616-odmnvv7m 219 18 led lead VBD cord-276616-odmnvv7m 219 19 indirectly indirectly RB cord-276616-odmnvv7m 219 20 to to IN cord-276616-odmnvv7m 219 21 the the DT cord-276616-odmnvv7m 219 22 initial initial JJ cord-276616-odmnvv7m 219 23 major major JJ cord-276616-odmnvv7m 219 24 studies study NNS cord-276616-odmnvv7m 219 25 on on IN cord-276616-odmnvv7m 219 26 scrapie scrapie NN cord-276616-odmnvv7m 219 27 ( ( -LRB- cord-276616-odmnvv7m 219 28 see see VB cord-276616-odmnvv7m 219 29 above above RB cord-276616-odmnvv7m 219 30 ) ) -RRB- cord-276616-odmnvv7m 219 31 . . . cord-276616-odmnvv7m 220 1 Could Could MD cord-276616-odmnvv7m 220 2 vaccination vaccination VB cord-276616-odmnvv7m 220 3 against against IN cord-276616-odmnvv7m 220 4 infection infection NN cord-276616-odmnvv7m 220 5 with with IN cord-276616-odmnvv7m 220 6 this this DT cord-276616-odmnvv7m 220 7 virus virus NN cord-276616-odmnvv7m 220 8 have have VBP cord-276616-odmnvv7m 220 9 increased increase VBN cord-276616-odmnvv7m 220 10 the the DT cord-276616-odmnvv7m 220 11 susceptibility susceptibility NN cord-276616-odmnvv7m 220 12 to to IN cord-276616-odmnvv7m 220 13 scrapie scrapie NN cord-276616-odmnvv7m 220 14 ? ? . cord-276616-odmnvv7m 221 1 Another another DT cord-276616-odmnvv7m 221 2 virus virus NN cord-276616-odmnvv7m 221 3 that that WDT cord-276616-odmnvv7m 221 4 has have VBZ cord-276616-odmnvv7m 221 5 been be VBN cord-276616-odmnvv7m 221 6 mentioned mention VBN cord-276616-odmnvv7m 221 7 in in IN cord-276616-odmnvv7m 221 8 the the DT cord-276616-odmnvv7m 221 9 context context NN cord-276616-odmnvv7m 221 10 of of IN cord-276616-odmnvv7m 221 11 scrapie scrapie NN cord-276616-odmnvv7m 221 12 causation causation NN cord-276616-odmnvv7m 221 13 is be VBZ cord-276616-odmnvv7m 221 14 the the DT cord-276616-odmnvv7m 221 15 hepadnavirus hepadnavirus NNP cord-276616-odmnvv7m 221 16 . . . cord-276616-odmnvv7m 222 1 Some some DT cord-276616-odmnvv7m 222 2 time time NN cord-276616-odmnvv7m 222 3 ago ago RB cord-276616-odmnvv7m 222 4 , , , cord-276616-odmnvv7m 222 5 Carl Carl NNP cord-276616-odmnvv7m 222 6 Eklund Eklund NNP cord-276616-odmnvv7m 222 7 stated state VBD cord-276616-odmnvv7m 222 8 that that IN cord-276616-odmnvv7m 222 9 ' ' `` cord-276616-odmnvv7m 222 10 the the DT cord-276616-odmnvv7m 222 11 scrapie scrapie NN cord-276616-odmnvv7m 222 12 agent agent NN cord-276616-odmnvv7m 222 13 is be VBZ cord-276616-odmnvv7m 222 14 not not RB cord-276616-odmnvv7m 222 15 a a DT cord-276616-odmnvv7m 222 16 member member NN cord-276616-odmnvv7m 222 17 of of IN cord-276616-odmnvv7m 222 18 a a DT cord-276616-odmnvv7m 222 19 unique unique JJ cord-276616-odmnvv7m 222 20 group group NN cord-276616-odmnvv7m 222 21 of of IN cord-276616-odmnvv7m 222 22 pathogens pathogen NNS cord-276616-odmnvv7m 222 23 but but CC cord-276616-odmnvv7m 222 24 is be VBZ cord-276616-odmnvv7m 222 25 a a DT cord-276616-odmnvv7m 222 26 medium medium JJ cord-276616-odmnvv7m 222 27 - - HYPH cord-276616-odmnvv7m 222 28 sized sized JJ cord-276616-odmnvv7m 222 29 virus virus NN cord-276616-odmnvv7m 222 30 whose whose WP$ cord-276616-odmnvv7m 222 31 resistance resistance NN cord-276616-odmnvv7m 222 32 to to IN cord-276616-odmnvv7m 222 33 heat heat NN cord-276616-odmnvv7m 222 34 is be VBZ cord-276616-odmnvv7m 222 35 analogous analogous JJ cord-276616-odmnvv7m 222 36 to to IN cord-276616-odmnvv7m 222 37 that that DT cord-276616-odmnvv7m 222 38 of of IN cord-276616-odmnvv7m 222 39 serum serum NN cord-276616-odmnvv7m 222 40 hepatitis hepatitis NN cord-276616-odmnvv7m 222 41 virus virus NN cord-276616-odmnvv7m 222 42 ' ' '' cord-276616-odmnvv7m 222 43 ( ( -LRB- cord-276616-odmnvv7m 222 44 Hotchin Hotchin NNP cord-276616-odmnvv7m 222 45 , , , cord-276616-odmnvv7m 222 46 1979 1979 CD cord-276616-odmnvv7m 222 47 ) ) -RRB- cord-276616-odmnvv7m 222 48 . . . cord-276616-odmnvv7m 223 1 This this DT cord-276616-odmnvv7m 223 2 suggestion suggestion NN cord-276616-odmnvv7m 223 3 seems seem VBZ cord-276616-odmnvv7m 223 4 to to TO cord-276616-odmnvv7m 223 5 have have VB cord-276616-odmnvv7m 223 6 attracted attract VBN cord-276616-odmnvv7m 223 7 little little JJ cord-276616-odmnvv7m 223 8 attention attention NN cord-276616-odmnvv7m 223 9 , , , cord-276616-odmnvv7m 223 10 but but CC cord-276616-odmnvv7m 223 11 there there EX cord-276616-odmnvv7m 223 12 is be VBZ cord-276616-odmnvv7m 223 13 a a DT cord-276616-odmnvv7m 223 14 strong strong JJ cord-276616-odmnvv7m 223 15 possibility possibility NN cord-276616-odmnvv7m 223 16 that that IN cord-276616-odmnvv7m 223 17 hepatitis hepatitis NN cord-276616-odmnvv7m 223 18 B b NN cord-276616-odmnvv7m 223 19 viruses virus NNS cord-276616-odmnvv7m 223 20 ( ( -LRB- cord-276616-odmnvv7m 223 21 Tiollais Tiollais NNP cord-276616-odmnvv7m 223 22 and and CC cord-276616-odmnvv7m 223 23 Buendia Buendia NNP cord-276616-odmnvv7m 223 24 , , , cord-276616-odmnvv7m 223 25 1991 1991 CD cord-276616-odmnvv7m 223 26 ) ) -RRB- cord-276616-odmnvv7m 223 27 are be VBP cord-276616-odmnvv7m 223 28 more more RBR cord-276616-odmnvv7m 223 29 widespread widespread JJ cord-276616-odmnvv7m 223 30 than than IN cord-276616-odmnvv7m 223 31 previously previously RB cord-276616-odmnvv7m 223 32 believed believe VBN cord-276616-odmnvv7m 223 33 . . . cord-276616-odmnvv7m 224 1 Viruses virus NNS cord-276616-odmnvv7m 224 2 similar similar JJ cord-276616-odmnvv7m 224 3 to to IN cord-276616-odmnvv7m 224 4 human human JJ cord-276616-odmnvv7m 224 5 hepatitis hepatitis NN cord-276616-odmnvv7m 224 6 B B NNP cord-276616-odmnvv7m 224 7 virus virus NN cord-276616-odmnvv7m 224 8 have have VBP cord-276616-odmnvv7m 224 9 been be VBN cord-276616-odmnvv7m 224 10 found find VBN cord-276616-odmnvv7m 224 11 in in IN cord-276616-odmnvv7m 224 12 woodchucks woodchuck NNS cord-276616-odmnvv7m 224 13 and and CC cord-276616-odmnvv7m 224 14 ground ground NN cord-276616-odmnvv7m 224 15 squirrels squirrel NNS cord-276616-odmnvv7m 225 1 ( ( -LRB- cord-276616-odmnvv7m 225 2 Minuk Minuk NNP cord-276616-odmnvv7m 225 3 et et FW cord-276616-odmnvv7m 225 4 al al NNP cord-276616-odmnvv7m 225 5 . . NNP cord-276616-odmnvv7m 225 6 , , , cord-276616-odmnvv7m 225 7 1986 1986 CD cord-276616-odmnvv7m 225 8 ) ) -RRB- cord-276616-odmnvv7m 225 9 , , , cord-276616-odmnvv7m 225 10 while while IN cord-276616-odmnvv7m 225 11 antibody antibody NN cord-276616-odmnvv7m 225 12 to to IN cord-276616-odmnvv7m 225 13 this this DT cord-276616-odmnvv7m 225 14 virus virus NN cord-276616-odmnvv7m 225 15 can can MD cord-276616-odmnvv7m 225 16 be be VB cord-276616-odmnvv7m 225 17 demonstrated demonstrate VBN cord-276616-odmnvv7m 225 18 in in IN cord-276616-odmnvv7m 225 19 many many JJ cord-276616-odmnvv7m 225 20 other other JJ cord-276616-odmnvv7m 225 21 animals animal NNS cord-276616-odmnvv7m 225 22 , , , cord-276616-odmnvv7m 225 23 including include VBG cord-276616-odmnvv7m 225 24 pigs pig NNS cord-276616-odmnvv7m 225 25 , , , cord-276616-odmnvv7m 225 26 goats goat NNS cord-276616-odmnvv7m 225 27 , , , cord-276616-odmnvv7m 225 28 cattle cattle NNS cord-276616-odmnvv7m 225 29 and and CC cord-276616-odmnvv7m 225 30 especially especially RB cord-276616-odmnvv7m 225 31 sheep sheep NN cord-276616-odmnvv7m 225 32 ( ( -LRB- cord-276616-odmnvv7m 225 33 Hoofnagle Hoofnagle NNP cord-276616-odmnvv7m 225 34 et et NNP cord-276616-odmnvv7m 225 35 al al NNP cord-276616-odmnvv7m 225 36 . . NNP cord-276616-odmnvv7m 225 37 , , , cord-276616-odmnvv7m 225 38 1983 1983 CD cord-276616-odmnvv7m 225 39 ) ) -RRB- cord-276616-odmnvv7m 225 40 . . . cord-276616-odmnvv7m 226 1 Of of IN cord-276616-odmnvv7m 226 2 particular particular JJ cord-276616-odmnvv7m 226 3 interest interest NN cord-276616-odmnvv7m 226 4 , , , cord-276616-odmnvv7m 226 5 with with IN cord-276616-odmnvv7m 226 6 relation relation NN cord-276616-odmnvv7m 226 7 to to IN cord-276616-odmnvv7m 226 8 the the DT cord-276616-odmnvv7m 226 9 virino virino NN cord-276616-odmnvv7m 226 10 hypothesis hypothesis NN cord-276616-odmnvv7m 226 11 of of IN cord-276616-odmnvv7m 226 12 scrapie scrapie NN cord-276616-odmnvv7m 226 13 , , , cord-276616-odmnvv7m 226 14 is be VBZ cord-276616-odmnvv7m 226 15 the the DT cord-276616-odmnvv7m 226 16 fact fact NN cord-276616-odmnvv7m 226 17 that that IN cord-276616-odmnvv7m 226 18 another another DT cord-276616-odmnvv7m 226 19 agent agent NN cord-276616-odmnvv7m 226 20 is be VBZ cord-276616-odmnvv7m 226 21 associated associate VBN cord-276616-odmnvv7m 226 22 with with IN cord-276616-odmnvv7m 226 23 hepatitis hepatitis NN cord-276616-odmnvv7m 226 24 B B NNP cord-276616-odmnvv7m 226 25 virus virus NN cord-276616-odmnvv7m 226 26 . . . cord-276616-odmnvv7m 227 1 This this DT cord-276616-odmnvv7m 227 2 agent agent NN cord-276616-odmnvv7m 227 3 is be VBZ cord-276616-odmnvv7m 227 4 the the DT cord-276616-odmnvv7m 227 5 hepatitis hepatitis NN cord-276616-odmnvv7m 227 6 delta delta NNP cord-276616-odmnvv7m 227 7 virus virus NN cord-276616-odmnvv7m 227 8 ( ( -LRB- cord-276616-odmnvv7m 227 9 HDV HDV NNP cord-276616-odmnvv7m 227 10 ) ) -RRB- cord-276616-odmnvv7m 227 11 . . . cord-276616-odmnvv7m 228 1 HDV HDV NNP cord-276616-odmnvv7m 228 2 is be VBZ cord-276616-odmnvv7m 228 3 a a DT cord-276616-odmnvv7m 228 4 small small JJ cord-276616-odmnvv7m 228 5 defective defective JJ cord-276616-odmnvv7m 228 6 viroid viroid JJ cord-276616-odmnvv7m 228 7 - - HYPH cord-276616-odmnvv7m 228 8 like like JJ cord-276616-odmnvv7m 228 9 RNA RNA NNP cord-276616-odmnvv7m 228 10 virus virus NN cord-276616-odmnvv7m 228 11 ( ( -LRB- cord-276616-odmnvv7m 228 12 Negro Negro NNP cord-276616-odmnvv7m 228 13 et et FW cord-276616-odmnvv7m 228 14 al al NNP cord-276616-odmnvv7m 228 15 . . NNP cord-276616-odmnvv7m 228 16 , , , cord-276616-odmnvv7m 228 17 1989 1989 CD cord-276616-odmnvv7m 228 18 ) ) -RRB- cord-276616-odmnvv7m 228 19 that that WDT cord-276616-odmnvv7m 228 20 requires require VBZ cord-276616-odmnvv7m 228 21 another another DT cord-276616-odmnvv7m 228 22 virus virus NN cord-276616-odmnvv7m 228 23 , , , cord-276616-odmnvv7m 228 24 hepatitis hepatitis NN cord-276616-odmnvv7m 228 25 B B NNP cord-276616-odmnvv7m 228 26 virus virus NN cord-276616-odmnvv7m 228 27 , , , cord-276616-odmnvv7m 228 28 as as IN cord-276616-odmnvv7m 228 29 a a DT cord-276616-odmnvv7m 228 30 helper helper NN cord-276616-odmnvv7m 228 31 . . . cord-276616-odmnvv7m 229 1 Thus thus RB cord-276616-odmnvv7m 229 2 , , , cord-276616-odmnvv7m 229 3 even even RB cord-276616-odmnvv7m 229 4 if if IN cord-276616-odmnvv7m 229 5 hepatitis hepatitis NN cord-276616-odmnvv7m 229 6 B b NN cord-276616-odmnvv7m 229 7 viruses virus NNS cord-276616-odmnvv7m 229 8 are be VBP cord-276616-odmnvv7m 229 9 found find VBN cord-276616-odmnvv7m 229 10 in in IN cord-276616-odmnvv7m 229 11 farm farm NN cord-276616-odmnvv7m 229 12 animals animal NNS cord-276616-odmnvv7m 229 13 , , , cord-276616-odmnvv7m 229 14 the the DT cord-276616-odmnvv7m 229 15 search search NN cord-276616-odmnvv7m 229 16 should should MD cord-276616-odmnvv7m 229 17 not not RB cord-276616-odmnvv7m 229 18 stop stop VB cord-276616-odmnvv7m 229 19 there there RB cord-276616-odmnvv7m 229 20 but but CC cord-276616-odmnvv7m 229 21 continue continue VB cord-276616-odmnvv7m 229 22 with with IN cord-276616-odmnvv7m 229 23 a a DT cord-276616-odmnvv7m 229 24 search search NN cord-276616-odmnvv7m 229 25 for for IN cord-276616-odmnvv7m 229 26 HDV HDV NNP cord-276616-odmnvv7m 229 27 - - HYPH cord-276616-odmnvv7m 229 28 like like JJ cord-276616-odmnvv7m 229 29 viruses virus NNS cord-276616-odmnvv7m 229 30 . . . cord-276616-odmnvv7m 230 1 Humphrey Humphrey NNP cord-276616-odmnvv7m 230 2 - - HYPH cord-276616-odmnvv7m 230 3 Smith Smith NNP cord-276616-odmnvv7m 230 4 and and CC cord-276616-odmnvv7m 230 5 colleagues colleague NNS cord-276616-odmnvv7m 230 6 ( ( -LRB- cord-276616-odmnvv7m 230 7 1992 1992 CD cord-276616-odmnvv7m 230 8 ) ) -RRB- cord-276616-odmnvv7m 230 9 noted note VBD cord-276616-odmnvv7m 230 10 that that IN cord-276616-odmnvv7m 230 11 the the DT cord-276616-odmnvv7m 230 12 presence presence NN cord-276616-odmnvv7m 230 13 of of IN cord-276616-odmnvv7m 230 14 spiroplasma spiroplasma NNP cord-276616-odmnvv7m 230 15 - - HYPH cord-276616-odmnvv7m 230 16 like like JJ cord-276616-odmnvv7m 230 17 inclusions inclusion NNS cord-276616-odmnvv7m 230 18 has have VBZ cord-276616-odmnvv7m 230 19 repeatably repeatably RB cord-276616-odmnvv7m 230 20 been be VBN cord-276616-odmnvv7m 230 21 noted note VBN cord-276616-odmnvv7m 230 22 in in IN cord-276616-odmnvv7m 230 23 cases case NNS cord-276616-odmnvv7m 230 24 of of IN cord-276616-odmnvv7m 230 25 CJD CJD NNP cord-276616-odmnvv7m 230 26 , , , cord-276616-odmnvv7m 230 27 that that DT cord-276616-odmnvv7m 230 28 spiroplasmas spiroplasmas : cord-276616-odmnvv7m 230 29 show show VBP cord-276616-odmnvv7m 230 30 a a DT cord-276616-odmnvv7m 230 31 number number NN cord-276616-odmnvv7m 230 32 of of IN cord-276616-odmnvv7m 230 33 similarities similarity NNS cord-276616-odmnvv7m 230 34 with with IN cord-276616-odmnvv7m 230 35 the the DT cord-276616-odmnvv7m 230 36 scrapie scrapie NN cord-276616-odmnvv7m 230 37 - - HYPH cord-276616-odmnvv7m 230 38 associated associate VBN cord-276616-odmnvv7m 230 39 fibrillar fibrillar NNP cord-276616-odmnvv7m 230 40 protein protein NN cord-276616-odmnvv7m 230 41 ( ( -LRB- cord-276616-odmnvv7m 230 42 SAF SAF NNP cord-276616-odmnvv7m 230 43 ) ) -RRB- cord-276616-odmnvv7m 230 44 , , , cord-276616-odmnvv7m 230 45 and and CC cord-276616-odmnvv7m 230 46 that that IN cord-276616-odmnvv7m 230 47 lesions lesion NNS cord-276616-odmnvv7m 230 48 minicking minicke VBG cord-276616-odmnvv7m 230 49 spongiform spongiform JJ cord-276616-odmnvv7m 230 50 encephalopathy encephalopathy NN cord-276616-odmnvv7m 230 51 are be VBP cord-276616-odmnvv7m 230 52 produced produce VBN cord-276616-odmnvv7m 230 53 by by IN cord-276616-odmnvv7m 230 54 spiroplasma spiroplasma NN cord-276616-odmnvv7m 230 55 - - HYPH cord-276616-odmnvv7m 230 56 infected infect VBN cord-276616-odmnvv7m 230 57 rodents rodent NNS cord-276616-odmnvv7m 230 58 . . . cord-276616-odmnvv7m 231 1 Spiroplasmas spiroplasma NNS cord-276616-odmnvv7m 231 2 belong belong VBP cord-276616-odmnvv7m 231 3 to to IN cord-276616-odmnvv7m 231 4 the the DT cord-276616-odmnvv7m 231 5 Class Class NNP cord-276616-odmnvv7m 231 6 Mollicutes Mollicutes NNPS cord-276616-odmnvv7m 231 7 , , , cord-276616-odmnvv7m 231 8 Order Order NNP cord-276616-odmnvv7m 231 9 Mycoplasmatales Mycoplasmatales NNP cord-276616-odmnvv7m 231 10 . . . cord-276616-odmnvv7m 232 1 Like like IN cord-276616-odmnvv7m 232 2 mycoplasmas mycoplasmas NN cord-276616-odmnvv7m 232 3 , , , cord-276616-odmnvv7m 232 4 spiroplasmas spiroplasmas NN cord-276616-odmnvv7m 232 5 , , , cord-276616-odmnvv7m 232 6 some some DT cord-276616-odmnvv7m 232 7 of of IN cord-276616-odmnvv7m 232 8 which which WDT cord-276616-odmnvv7m 232 9 are be VBP cord-276616-odmnvv7m 232 10 pathogenic pathogenic JJ cord-276616-odmnvv7m 232 11 for for IN cord-276616-odmnvv7m 232 12 insects insect NNS cord-276616-odmnvv7m 232 13 and and CC cord-276616-odmnvv7m 232 14 plants plant NNS cord-276616-odmnvv7m 232 15 , , , cord-276616-odmnvv7m 232 16 are be VBP cord-276616-odmnvv7m 232 17 a a DT cord-276616-odmnvv7m 232 18 family family NN cord-276616-odmnvv7m 232 19 within within IN cord-276616-odmnvv7m 232 20 this this DT cord-276616-odmnvv7m 232 21 order order NN cord-276616-odmnvv7m 232 22 . . . cord-276616-odmnvv7m 233 1 Humphrey Humphrey NNP cord-276616-odmnvv7m 233 2 - - HYPH cord-276616-odmnvv7m 233 3 Smith Smith NNP cord-276616-odmnvv7m 233 4 and and CC cord-276616-odmnvv7m 233 5 colleagues colleague NNS cord-276616-odmnvv7m 233 6 ( ( -LRB- cord-276616-odmnvv7m 233 7 1992 1992 CD cord-276616-odmnvv7m 233 8 ) ) -RRB- cord-276616-odmnvv7m 233 9 suggested suggest VBD cord-276616-odmnvv7m 233 10 that that IN cord-276616-odmnvv7m 233 11 spiroplasmas spiroplasmas NN cord-276616-odmnvv7m 233 12 should should MD cord-276616-odmnvv7m 233 13 not not RB cord-276616-odmnvv7m 233 14 be be VB cord-276616-odmnvv7m 233 15 ignored ignore VBN cord-276616-odmnvv7m 233 16 as as IN cord-276616-odmnvv7m 233 17 a a DT cord-276616-odmnvv7m 233 18 possible possible JJ cord-276616-odmnvv7m 233 19 cause cause NN cord-276616-odmnvv7m 233 20 of of IN cord-276616-odmnvv7m 233 21 spongiform spongiform JJ cord-276616-odmnvv7m 233 22 encephalopathies encephalopathy NNS cord-276616-odmnvv7m 233 23 . . . cord-276616-odmnvv7m 234 1 There there EX cord-276616-odmnvv7m 234 2 are be VBP cord-276616-odmnvv7m 234 3 indeed indeed RB cord-276616-odmnvv7m 234 4 immunological immunological JJ cord-276616-odmnvv7m 234 5 cross cross NN cord-276616-odmnvv7m 234 6 - - NNS cord-276616-odmnvv7m 234 7 reactions reaction NNS cord-276616-odmnvv7m 234 8 between between IN cord-276616-odmnvv7m 234 9 the the DT cord-276616-odmnvv7m 234 10 proteinaseresistant proteinaseresistant JJ cord-276616-odmnvv7m 234 11 proteins protein NNS cord-276616-odmnvv7m 234 12 of of IN cord-276616-odmnvv7m 234 13 Spiroplasma Spiroplasma NNP cord-276616-odmnvv7m 234 14 mirum mirum NNP cord-276616-odmnvv7m 234 15 and and CC cord-276616-odmnvv7m 234 16 PrPSc PrPSc NNP cord-276616-odmnvv7m 235 1 ( ( -LRB- cord-276616-odmnvv7m 235 2 Bastian Bastian NNP cord-276616-odmnvv7m 235 3 et et NNP cord-276616-odmnvv7m 235 4 al al NNP cord-276616-odmnvv7m 235 5 . . NNP cord-276616-odmnvv7m 235 6 , , , cord-276616-odmnvv7m 235 7 1987 1987 CD cord-276616-odmnvv7m 235 8 ) ) -RRB- cord-276616-odmnvv7m 236 1 and and CC cord-276616-odmnvv7m 236 2 there there EX cord-276616-odmnvv7m 236 3 are be VBP cord-276616-odmnvv7m 236 4 proteinase proteinase NN cord-276616-odmnvv7m 236 5 - - HYPH cord-276616-odmnvv7m 236 6 K k NN cord-276616-odmnvv7m 236 7 - - HYPH cord-276616-odmnvv7m 236 8 resistant resistant JJ cord-276616-odmnvv7m 236 9 proteins protein NNS cord-276616-odmnvv7m 236 10 in in IN cord-276616-odmnvv7m 236 11 other other JJ cord-276616-odmnvv7m 236 12 members member NNS cord-276616-odmnvv7m 236 13 of of IN cord-276616-odmnvv7m 236 14 the the DT cord-276616-odmnvv7m 236 15 Class Class NNP cord-276616-odmnvv7m 236 16 Mollicutes Mollicutes NNPS cord-276616-odmnvv7m 237 1 ( ( -LRB- cord-276616-odmnvv7m 237 2 Butler Butler NNP cord-276616-odmnvv7m 237 3 et et NNP cord-276616-odmnvv7m 237 4 al al NNP cord-276616-odmnvv7m 237 5 . . NNP cord-276616-odmnvv7m 237 6 , , , cord-276616-odmnvv7m 237 7 1991 1991 CD cord-276616-odmnvv7m 237 8 ) ) -RRB- cord-276616-odmnvv7m 237 9 . . . cord-276616-odmnvv7m 238 1 It -PRON- PRP cord-276616-odmnvv7m 238 2 would would MD cord-276616-odmnvv7m 238 3 have have VB cord-276616-odmnvv7m 238 4 been be VBN cord-276616-odmnvv7m 238 5 thought think VBN cord-276616-odmnvv7m 238 6 that that IN cord-276616-odmnvv7m 238 7 articles article NNS cord-276616-odmnvv7m 238 8 would would MD cord-276616-odmnvv7m 238 9 have have VB cord-276616-odmnvv7m 238 10 appeared appear VBN cord-276616-odmnvv7m 238 11 by by IN cord-276616-odmnvv7m 238 12 now now RB cord-276616-odmnvv7m 238 13 listing list VBG cord-276616-odmnvv7m 238 14 attempts attempt NNS cord-276616-odmnvv7m 238 15 to to TO cord-276616-odmnvv7m 238 16 demonstrate demonstrate VB cord-276616-odmnvv7m 238 17 antibody antibody NN cord-276616-odmnvv7m 238 18 to to IN cord-276616-odmnvv7m 238 19 S. S. NNP cord-276616-odmnvv7m 238 20 mirum mirum NNP cord-276616-odmnvv7m 238 21 and and CC cord-276616-odmnvv7m 238 22 other other JJ cord-276616-odmnvv7m 238 23 spiroplasmas spiroplasmas NN cord-276616-odmnvv7m 238 24 in in IN cord-276616-odmnvv7m 238 25 the the DT cord-276616-odmnvv7m 238 26 sera sera NNP cord-276616-odmnvv7m 238 27 of of IN cord-276616-odmnvv7m 238 28 sheep sheep NNP cord-276616-odmnvv7m 238 29 with with IN cord-276616-odmnvv7m 238 30 scrapie scrapie NN cord-276616-odmnvv7m 238 31 and and CC cord-276616-odmnvv7m 238 32 cattle cattle NNS cord-276616-odmnvv7m 238 33 with with IN cord-276616-odmnvv7m 238 34 BSE BSE NNP cord-276616-odmnvv7m 238 35 and and CC cord-276616-odmnvv7m 238 36 attempts attempt VBZ cord-276616-odmnvv7m 238 37 to to TO cord-276616-odmnvv7m 238 38 correlate correlate VB cord-276616-odmnvv7m 238 39 the the DT cord-276616-odmnvv7m 238 40 titres titre NNS cord-276616-odmnvv7m 238 41 against against IN cord-276616-odmnvv7m 238 42 such such JJ cord-276616-odmnvv7m 238 43 agents agent NNS cord-276616-odmnvv7m 238 44 with with IN cord-276616-odmnvv7m 238 45 the the DT cord-276616-odmnvv7m 238 46 onset onset NN cord-276616-odmnvv7m 238 47 of of IN cord-276616-odmnvv7m 238 48 signs sign NNS cord-276616-odmnvv7m 238 49 , , , cord-276616-odmnvv7m 238 50 but but CC cord-276616-odmnvv7m 238 51 there there EX cord-276616-odmnvv7m 238 52 do do VBP cord-276616-odmnvv7m 238 53 not not RB cord-276616-odmnvv7m 238 54 appear appear VB cord-276616-odmnvv7m 238 55 to to TO cord-276616-odmnvv7m 238 56 have have VB cord-276616-odmnvv7m 238 57 been be VBN cord-276616-odmnvv7m 238 58 any any DT cord-276616-odmnvv7m 238 59 such such JJ cord-276616-odmnvv7m 238 60 papers paper NNS cord-276616-odmnvv7m 238 61 . . . cord-276616-odmnvv7m 239 1 Scrapie Scrapie NNP cord-276616-odmnvv7m 239 2 is be VBZ cord-276616-odmnvv7m 239 3 a a DT cord-276616-odmnvv7m 239 4 particularly particularly RB cord-276616-odmnvv7m 239 5 frightening frightening JJ cord-276616-odmnvv7m 239 6 disease disease NN cord-276616-odmnvv7m 239 7 . . . cord-276616-odmnvv7m 240 1 The the DT cord-276616-odmnvv7m 240 2 transmissible transmissible JJ cord-276616-odmnvv7m 240 3 agent agent NN cord-276616-odmnvv7m 240 4 is be VBZ cord-276616-odmnvv7m 240 5 very very RB cord-276616-odmnvv7m 240 6 resistant resistant JJ cord-276616-odmnvv7m 240 7 to to IN cord-276616-odmnvv7m 240 8 heat heat NN cord-276616-odmnvv7m 240 9 ( ( -LRB- cord-276616-odmnvv7m 240 10 Mould Mould NNP cord-276616-odmnvv7m 240 11 and and CC cord-276616-odmnvv7m 240 12 Dawson Dawson NNP cord-276616-odmnvv7m 240 13 , , , cord-276616-odmnvv7m 240 14 1970 1970 CD cord-276616-odmnvv7m 240 15 ) ) -RRB- cord-276616-odmnvv7m 240 16 and and CC cord-276616-odmnvv7m 240 17 to to IN cord-276616-odmnvv7m 240 18 other other JJ cord-276616-odmnvv7m 240 19 agents agent NNS cord-276616-odmnvv7m 240 20 normally normally RB cord-276616-odmnvv7m 240 21 destructive destructive JJ cord-276616-odmnvv7m 240 22 to to IN cord-276616-odmnvv7m 240 23 biological biological JJ cord-276616-odmnvv7m 240 24 materials material NNS cord-276616-odmnvv7m 240 25 and and CC cord-276616-odmnvv7m 240 26 it -PRON- PRP cord-276616-odmnvv7m 240 27 gives give VBZ cord-276616-odmnvv7m 240 28 the the DT cord-276616-odmnvv7m 240 29 appearance appearance NN cord-276616-odmnvv7m 240 30 of of IN cord-276616-odmnvv7m 240 31 an an DT cord-276616-odmnvv7m 240 32 ability ability NN cord-276616-odmnvv7m 240 33 to to TO cord-276616-odmnvv7m 240 34 cross cross VB cord-276616-odmnvv7m 240 35 species species NN cord-276616-odmnvv7m 240 36 boundaries boundary NNS cord-276616-odmnvv7m 240 37 . . . cord-276616-odmnvv7m 241 1 The the DT cord-276616-odmnvv7m 241 2 first first JJ cord-276616-odmnvv7m 241 3 clue clue NN cord-276616-odmnvv7m 241 4 to to IN cord-276616-odmnvv7m 241 5 the the DT cord-276616-odmnvv7m 241 6 resistance resistance NN cord-276616-odmnvv7m 241 7 of of IN cord-276616-odmnvv7m 241 8 the the DT cord-276616-odmnvv7m 241 9 agent agent NN cord-276616-odmnvv7m 241 10 came come VBD cord-276616-odmnvv7m 241 11 from from IN cord-276616-odmnvv7m 241 12 the the DT cord-276616-odmnvv7m 241 13 louping louping NN cord-276616-odmnvv7m 241 14 - - HYPH cord-276616-odmnvv7m 241 15 ill ill JJ cord-276616-odmnvv7m 241 16 vaccination vaccination NN cord-276616-odmnvv7m 241 17 trials trial NNS cord-276616-odmnvv7m 241 18 in in IN cord-276616-odmnvv7m 241 19 the the DT cord-276616-odmnvv7m 241 20 1930s 1930 NNS cord-276616-odmnvv7m 241 21 ( ( -LRB- cord-276616-odmnvv7m 241 22 see see VB cord-276616-odmnvv7m 241 23 introduction introduction NN cord-276616-odmnvv7m 241 24 ) ) -RRB- cord-276616-odmnvv7m 241 25 , , , cord-276616-odmnvv7m 241 26 where where WRB cord-276616-odmnvv7m 241 27 scrapie scrapie NN cord-276616-odmnvv7m 241 28 developed develop VBD cord-276616-odmnvv7m 241 29 following follow VBG cord-276616-odmnvv7m 241 30 the the DT cord-276616-odmnvv7m 241 31 inoculation inoculation NN cord-276616-odmnvv7m 241 32 of of IN cord-276616-odmnvv7m 241 33 formalinized formalinized JJ cord-276616-odmnvv7m 241 34 tissue tissue NN cord-276616-odmnvv7m 241 35 . . . cord-276616-odmnvv7m 242 1 While while IN cord-276616-odmnvv7m 242 2 later later RB cord-276616-odmnvv7m 242 3 shown show VBN cord-276616-odmnvv7m 242 4 not not RB cord-276616-odmnvv7m 242 5 to to TO cord-276616-odmnvv7m 242 6 be be VB cord-276616-odmnvv7m 242 7 completely completely RB cord-276616-odmnvv7m 242 8 resistant resistant JJ cord-276616-odmnvv7m 242 9 to to IN cord-276616-odmnvv7m 242 10 the the DT cord-276616-odmnvv7m 242 11 action action NN cord-276616-odmnvv7m 242 12 of of IN cord-276616-odmnvv7m 242 13 formalin formalin NN cord-276616-odmnvv7m 242 14 , , , cord-276616-odmnvv7m 242 15 the the DT cord-276616-odmnvv7m 242 16 agent agent NN cord-276616-odmnvv7m 242 17 's 's POS cord-276616-odmnvv7m 242 18 resistance resistance NN cord-276616-odmnvv7m 242 19 to to IN cord-276616-odmnvv7m 242 20 a a DT cord-276616-odmnvv7m 242 21 number number NN cord-276616-odmnvv7m 242 22 of of IN cord-276616-odmnvv7m 242 23 other other JJ cord-276616-odmnvv7m 242 24 disinfectants disinfectant NNS cord-276616-odmnvv7m 242 25 is be VBZ cord-276616-odmnvv7m 242 26 unexpectedly unexpectedly RB cord-276616-odmnvv7m 242 27 high high JJ cord-276616-odmnvv7m 242 28 for for IN cord-276616-odmnvv7m 242 29 the the DT cord-276616-odmnvv7m 242 30 viruses virus NNS cord-276616-odmnvv7m 242 31 and and CC cord-276616-odmnvv7m 242 32 similar similar JJ cord-276616-odmnvv7m 242 33 agents agent NNS cord-276616-odmnvv7m 242 34 with with IN cord-276616-odmnvv7m 242 35 which which WDT cord-276616-odmnvv7m 242 36 we -PRON- PRP cord-276616-odmnvv7m 242 37 are be VBP cord-276616-odmnvv7m 242 38 familiar familiar JJ cord-276616-odmnvv7m 242 39 . . . cord-276616-odmnvv7m 243 1 Further further RB cord-276616-odmnvv7m 243 2 , , , cord-276616-odmnvv7m 243 3 studies study NNS cord-276616-odmnvv7m 243 4 on on IN cord-276616-odmnvv7m 243 5 the the DT cord-276616-odmnvv7m 243 6 critical critical JJ cord-276616-odmnvv7m 243 7 size size NN cord-276616-odmnvv7m 243 8 of of IN cord-276616-odmnvv7m 243 9 the the DT cord-276616-odmnvv7m 243 10 agent agent NN cord-276616-odmnvv7m 243 11 by by IN cord-276616-odmnvv7m 243 12 X x NN cord-276616-odmnvv7m 243 13 - - NN cord-276616-odmnvv7m 243 14 irradiation irradiation NN cord-276616-odmnvv7m 243 15 and and CC cord-276616-odmnvv7m 243 16 by by IN cord-276616-odmnvv7m 243 17 exclusion exclusion NN cord-276616-odmnvv7m 243 18 chromatography chromatography NN cord-276616-odmnvv7m 243 19 give give VBP cord-276616-odmnvv7m 243 20 very very RB cord-276616-odmnvv7m 243 21 different different JJ cord-276616-odmnvv7m 243 22 estimates estimate NNS cord-276616-odmnvv7m 243 23 of of IN cord-276616-odmnvv7m 243 24 the the DT cord-276616-odmnvv7m 243 25 limiting limit VBG cord-276616-odmnvv7m 243 26 size size NN cord-276616-odmnvv7m 243 27 of of IN cord-276616-odmnvv7m 243 28 the the DT cord-276616-odmnvv7m 243 29 agent agent NN cord-276616-odmnvv7m 243 30 . . . cord-276616-odmnvv7m 244 1 X x NN cord-276616-odmnvv7m 244 2 - - NN cord-276616-odmnvv7m 244 3 ray ray NN cord-276616-odmnvv7m 244 4 studies study NNS cord-276616-odmnvv7m 244 5 suggest suggest VBP cord-276616-odmnvv7m 244 6 a a DT cord-276616-odmnvv7m 244 7 size size NN cord-276616-odmnvv7m 244 8 of of IN cord-276616-odmnvv7m 244 9 1.5 1.5 CD cord-276616-odmnvv7m 244 10 x x SYM cord-276616-odmnvv7m 244 11 102 102 CD cord-276616-odmnvv7m 244 12 kDa kDa NNS cord-276616-odmnvv7m 244 13 , , , cord-276616-odmnvv7m 244 14 while while IN cord-276616-odmnvv7m 244 15 the the DT cord-276616-odmnvv7m 244 16 much much RB cord-276616-odmnvv7m 244 17 larger large JJR cord-276616-odmnvv7m 244 18 figure figure NN cord-276616-odmnvv7m 244 19 of of IN cord-276616-odmnvv7m 244 20 5 5 CD cord-276616-odmnvv7m 244 21 × × NN cord-276616-odmnvv7m 244 22 104 104 CD cord-276616-odmnvv7m 244 23 kDa kDa NNPS cord-276616-odmnvv7m 244 24 is be VBZ cord-276616-odmnvv7m 244 25 suggested suggest VBN cord-276616-odmnvv7m 244 26 by by IN cord-276616-odmnvv7m 244 27 chromatographic chromatographic JJ cord-276616-odmnvv7m 244 28 studies study NNS cord-276616-odmnvv7m 244 29 . . . cord-276616-odmnvv7m 245 1 This this DT cord-276616-odmnvv7m 245 2 difference difference NN cord-276616-odmnvv7m 245 3 suggested suggest VBD cord-276616-odmnvv7m 245 4 to to IN cord-276616-odmnvv7m 245 5 Hunter Hunter NNP cord-276616-odmnvv7m 245 6 ( ( -LRB- cord-276616-odmnvv7m 245 7 1979 1979 CD cord-276616-odmnvv7m 245 8 ) ) -RRB- cord-276616-odmnvv7m 245 9 , , , cord-276616-odmnvv7m 245 10 a a DT cord-276616-odmnvv7m 245 11 source source NN cord-276616-odmnvv7m 245 12 for for IN cord-276616-odmnvv7m 245 13 much much JJ cord-276616-odmnvv7m 245 14 data datum NNS cord-276616-odmnvv7m 245 15 on on IN cord-276616-odmnvv7m 245 16 the the DT cord-276616-odmnvv7m 245 17 physical physical JJ cord-276616-odmnvv7m 245 18 properties property NNS cord-276616-odmnvv7m 245 19 of of IN cord-276616-odmnvv7m 245 20 the the DT cord-276616-odmnvv7m 245 21 scrapie scrapie NN cord-276616-odmnvv7m 245 22 agent agent NN cord-276616-odmnvv7m 245 23 , , , cord-276616-odmnvv7m 245 24 that that IN cord-276616-odmnvv7m 245 25 a a DT cord-276616-odmnvv7m 245 26 two two CD cord-276616-odmnvv7m 245 27 - - HYPH cord-276616-odmnvv7m 245 28 component component NN cord-276616-odmnvv7m 245 29 system system NN cord-276616-odmnvv7m 245 30 was be VBD cord-276616-odmnvv7m 245 31 necessary necessary JJ cord-276616-odmnvv7m 245 32 for for IN cord-276616-odmnvv7m 245 33 scrapie scrapie NN cord-276616-odmnvv7m 245 34 infectivity infectivity NN cord-276616-odmnvv7m 245 35 , , , cord-276616-odmnvv7m 245 36 a a DT cord-276616-odmnvv7m 245 37 small small JJ cord-276616-odmnvv7m 245 38 informational informational JJ cord-276616-odmnvv7m 245 39 component component NN cord-276616-odmnvv7m 245 40 that that WDT cord-276616-odmnvv7m 245 41 provides provide VBZ cord-276616-odmnvv7m 245 42 the the DT cord-276616-odmnvv7m 245 43 radiation radiation NN cord-276616-odmnvv7m 245 44 target target NN cord-276616-odmnvv7m 245 45 , , , cord-276616-odmnvv7m 245 46 and and CC cord-276616-odmnvv7m 245 47 a a DT cord-276616-odmnvv7m 245 48 larger large JJR cord-276616-odmnvv7m 245 49 component component NN cord-276616-odmnvv7m 245 50 that that WDT cord-276616-odmnvv7m 245 51 provides provide VBZ cord-276616-odmnvv7m 245 52 a a DT cord-276616-odmnvv7m 245 53 protective protective JJ cord-276616-odmnvv7m 245 54 or or CC cord-276616-odmnvv7m 245 55 carrier carrier NN cord-276616-odmnvv7m 245 56 role role NN cord-276616-odmnvv7m 245 57 . . . cord-276616-odmnvv7m 246 1 Hunter Hunter NNP cord-276616-odmnvv7m 246 2 ( ( -LRB- cord-276616-odmnvv7m 246 3 1979 1979 CD cord-276616-odmnvv7m 246 4 ) ) -RRB- cord-276616-odmnvv7m 246 5 also also RB cord-276616-odmnvv7m 246 6 indicated indicate VBD cord-276616-odmnvv7m 246 7 that that IN cord-276616-odmnvv7m 246 8 only only JJ cord-276616-odmnvv7m 246 9 proteases protease NNS cord-276616-odmnvv7m 246 10 have have VBP cord-276616-odmnvv7m 246 11 much much JJ cord-276616-odmnvv7m 246 12 effect effect NN cord-276616-odmnvv7m 246 13 on on IN cord-276616-odmnvv7m 246 14 scrapie scrapie NN cord-276616-odmnvv7m 246 15 activity activity NN cord-276616-odmnvv7m 246 16 and and CC cord-276616-odmnvv7m 246 17 that that IN cord-276616-odmnvv7m 246 18 , , , cord-276616-odmnvv7m 246 19 even even RB cord-276616-odmnvv7m 246 20 for for IN cord-276616-odmnvv7m 246 21 this this DT cord-276616-odmnvv7m 246 22 effect effect NN cord-276616-odmnvv7m 246 23 to to TO cord-276616-odmnvv7m 246 24 occur occur VB cord-276616-odmnvv7m 246 25 , , , cord-276616-odmnvv7m 246 26 the the DT cord-276616-odmnvv7m 246 27 substantial substantial JJ cord-276616-odmnvv7m 246 28 amounts amount NNS cord-276616-odmnvv7m 246 29 of of IN cord-276616-odmnvv7m 246 30 lipid lipid NN cord-276616-odmnvv7m 246 31 associated associate VBN cord-276616-odmnvv7m 246 32 with with IN cord-276616-odmnvv7m 246 33 brain brain NN cord-276616-odmnvv7m 246 34 tissue tissue NN cord-276616-odmnvv7m 246 35 must must MD cord-276616-odmnvv7m 246 36 be be VB cord-276616-odmnvv7m 246 37 removed remove VBN cord-276616-odmnvv7m 246 38 . . . cord-276616-odmnvv7m 247 1 Part part NN cord-276616-odmnvv7m 247 2 of of IN cord-276616-odmnvv7m 247 3 the the DT cord-276616-odmnvv7m 247 4 evidence evidence NN cord-276616-odmnvv7m 247 5 that that WDT cord-276616-odmnvv7m 247 6 led lead VBD cord-276616-odmnvv7m 247 7 to to IN cord-276616-odmnvv7m 247 8 the the DT cord-276616-odmnvv7m 247 9 prion prion NN cord-276616-odmnvv7m 247 10 concept concept NN cord-276616-odmnvv7m 247 11 was be VBD cord-276616-odmnvv7m 247 12 the the DT cord-276616-odmnvv7m 247 13 finding finding NN cord-276616-odmnvv7m 247 14 that that IN cord-276616-odmnvv7m 247 15 the the DT cord-276616-odmnvv7m 247 16 proteinase proteinase NN cord-276616-odmnvv7m 247 17 Pronase Pronase NNP cord-276616-odmnvv7m 247 18 destroyed destroy VBD cord-276616-odmnvv7m 247 19 the the DT cord-276616-odmnvv7m 247 20 activity activity NN cord-276616-odmnvv7m 247 21 of of IN cord-276616-odmnvv7m 247 22 the the DT cord-276616-odmnvv7m 247 23 agent agent NN cord-276616-odmnvv7m 247 24 . . . cord-276616-odmnvv7m 248 1 This this DT cord-276616-odmnvv7m 248 2 pointed point VBD cord-276616-odmnvv7m 248 3 to to IN cord-276616-odmnvv7m 248 4 a a DT cord-276616-odmnvv7m 248 5 need need NN cord-276616-odmnvv7m 248 6 for for IN cord-276616-odmnvv7m 248 7 a a DT cord-276616-odmnvv7m 248 8 protein protein NN cord-276616-odmnvv7m 248 9 component component NN cord-276616-odmnvv7m 248 10 for for IN cord-276616-odmnvv7m 248 11 its -PRON- PRP$ cord-276616-odmnvv7m 248 12 infectivity infectivity NN cord-276616-odmnvv7m 248 13 ( ( -LRB- cord-276616-odmnvv7m 248 14 Cho Cho NNP cord-276616-odmnvv7m 248 15 , , , cord-276616-odmnvv7m 248 16 1980 1980 CD cord-276616-odmnvv7m 248 17 ( ( -LRB- cord-276616-odmnvv7m 248 18 Cho Cho NNP cord-276616-odmnvv7m 248 19 , , , cord-276616-odmnvv7m 248 20 , , , cord-276616-odmnvv7m 248 21 1983 1983 CD cord-276616-odmnvv7m 248 22 . . . cord-276616-odmnvv7m 249 1 However however RB cord-276616-odmnvv7m 249 2 , , , cord-276616-odmnvv7m 249 3 certain certain JJ cord-276616-odmnvv7m 249 4 tissues tissue NNS cord-276616-odmnvv7m 249 5 contain contain VBP cord-276616-odmnvv7m 249 6 proteinase proteinase NN cord-276616-odmnvv7m 249 7 inhibitors inhibitor NNS cord-276616-odmnvv7m 249 8 that that WDT cord-276616-odmnvv7m 249 9 can can MD cord-276616-odmnvv7m 249 10 block block VB cord-276616-odmnvv7m 249 11 the the DT cord-276616-odmnvv7m 249 12 effectiveness effectiveness NN cord-276616-odmnvv7m 249 13 of of IN cord-276616-odmnvv7m 249 14 proteinases proteinases NNP cord-276616-odmnvv7m 249 15 and and CC cord-276616-odmnvv7m 249 16 , , , cord-276616-odmnvv7m 249 17 in in IN cord-276616-odmnvv7m 249 18 studies study NNS cord-276616-odmnvv7m 249 19 on on IN cord-276616-odmnvv7m 249 20 the the DT cord-276616-odmnvv7m 249 21 kind kind NN cord-276616-odmnvv7m 249 22 of of IN cord-276616-odmnvv7m 249 23 activity activity NN cord-276616-odmnvv7m 249 24 proteinases proteinase NNS cord-276616-odmnvv7m 249 25 have have VBP cord-276616-odmnvv7m 249 26 on on IN cord-276616-odmnvv7m 249 27 brain brain NN cord-276616-odmnvv7m 249 28 extracts extract NNS cord-276616-odmnvv7m 249 29 , , , cord-276616-odmnvv7m 249 30 Darcel Darcel NNP cord-276616-odmnvv7m 249 31 ( ( -LRB- cord-276616-odmnvv7m 249 32 1990 1990 CD cord-276616-odmnvv7m 249 33 ) ) -RRB- cord-276616-odmnvv7m 249 34 found find VBD cord-276616-odmnvv7m 249 35 that that IN cord-276616-odmnvv7m 249 36 Pronase Pronase NNP cord-276616-odmnvv7m 249 37 , , , cord-276616-odmnvv7m 249 38 highly highly RB cord-276616-odmnvv7m 249 39 active active JJ cord-276616-odmnvv7m 249 40 in in IN cord-276616-odmnvv7m 249 41 control control NN cord-276616-odmnvv7m 249 42 tests test NNS cord-276616-odmnvv7m 249 43 on on IN cord-276616-odmnvv7m 249 44 sheep sheep NNP cord-276616-odmnvv7m 249 45 l';aemoglobin l';aemoglobin NNP cord-276616-odmnvv7m 249 46 , , , cord-276616-odmnvv7m 249 47 had have VBD cord-276616-odmnvv7m 249 48 no no DT cord-276616-odmnvv7m 249 49 proteolytic proteolytic JJ cord-276616-odmnvv7m 249 50 effect effect NN cord-276616-odmnvv7m 249 51 on on IN cord-276616-odmnvv7m 249 52 the the DT cord-276616-odmnvv7m 249 53 Hirt Hirt NNP cord-276616-odmnvv7m 249 54 supernatant supernatant NN cord-276616-odmnvv7m 249 55 of of IN cord-276616-odmnvv7m 249 56 normal normal JJ cord-276616-odmnvv7m 249 57 mouse mouse NN cord-276616-odmnvv7m 249 58 brain brain NN cord-276616-odmnvv7m 249 59 . . . cord-276616-odmnvv7m 250 1 Reasons reason NNS cord-276616-odmnvv7m 250 2 for for IN cord-276616-odmnvv7m 250 3 this this DT cord-276616-odmnvv7m 250 4 lack lack NN cord-276616-odmnvv7m 250 5 of of IN cord-276616-odmnvv7m 250 6 activity activity NN cord-276616-odmnvv7m 250 7 with with IN cord-276616-odmnvv7m 250 8 brain brain NN cord-276616-odmnvv7m 250 9 extracts extract NNS cord-276616-odmnvv7m 250 10 should should MD cord-276616-odmnvv7m 250 11 be be VB cord-276616-odmnvv7m 250 12 explored explore VBN cord-276616-odmnvv7m 250 13 and and CC cord-276616-odmnvv7m 250 14 extended extend VBN cord-276616-odmnvv7m 250 15 to to IN cord-276616-odmnvv7m 250 16 proteinase proteinase NN cord-276616-odmnvv7m 250 17 - - HYPH cord-276616-odmnvv7m 250 18 K k NN cord-276616-odmnvv7m 250 19 , , , cord-276616-odmnvv7m 250 20 to to TO cord-276616-odmnvv7m 250 21 which which WDT cord-276616-odmnvv7m 250 22 PrPSc prpsc NN cord-276616-odmnvv7m 250 23 is be VBZ cord-276616-odmnvv7m 250 24 more more RBR cord-276616-odmnvv7m 250 25 resistant resistant JJ cord-276616-odmnvv7m 250 26 that that IN cord-276616-odmnvv7m 250 27 its -PRON- PRP$ cord-276616-odmnvv7m 250 28 homologue homologue NN cord-276616-odmnvv7m 250 29 in in IN cord-276616-odmnvv7m 250 30 normal normal JJ cord-276616-odmnvv7m 250 31 mouse mouse NN cord-276616-odmnvv7m 250 32 brain brain NN cord-276616-odmnvv7m 250 33 6 6 CD cord-276616-odmnvv7m 250 34 . . . cord-276616-odmnvv7m 251 1 The the DT cord-276616-odmnvv7m 251 2 sensitivity sensitivity NN cord-276616-odmnvv7m 251 3 to to IN cord-276616-odmnvv7m 251 4 this this DT cord-276616-odmnvv7m 251 5 enzyme enzyme NN cord-276616-odmnvv7m 251 6 was be VBD cord-276616-odmnvv7m 251 7 found find VBN cord-276616-odmnvv7m 251 8 to to IN cord-276616-odmnvv7m 251 9 va~ va~ NN cord-276616-odmnvv7m 251 10 between between IN cord-276616-odmnvv7m 251 11 three three CD cord-276616-odmnvv7m 251 12 stains stain NNS cord-276616-odmnvv7m 251 13 of of IN cord-276616-odmnvv7m 251 14 the the DT cord-276616-odmnvv7m 251 15 mouse mouse NN cord-276616-odmnvv7m 251 16 - - HYPH cord-276616-odmnvv7m 251 17 passaged passage VBN cord-276616-odmnvv7m 251 18 scrapie scrapie NN cord-276616-odmnvv7m 251 19 agent agent NN cord-276616-odmnvv7m 251 20 ( ( -LRB- cord-276616-odmnvv7m 251 21 Kascak Kascak NNP cord-276616-odmnvv7m 251 22 et et NNP cord-276616-odmnvv7m 251 23 al al NNP cord-276616-odmnvv7m 251 24 . . NNP cord-276616-odmnvv7m 251 25 , , , cord-276616-odmnvv7m 251 26 1985 1985 CD cord-276616-odmnvv7m 251 27 ) ) -RRB- cord-276616-odmnvv7m 251 28 ' ' '' cord-276616-odmnvv7m 251 29 . . . cord-276616-odmnvv7m 252 1 Without without IN cord-276616-odmnvv7m 252 2 data datum NNS cord-276616-odmnvv7m 252 3 on on IN cord-276616-odmnvv7m 252 4 what what WP cord-276616-odmnvv7m 252 5 the the DT cord-276616-odmnvv7m 252 6 proteinase proteinase NN cord-276616-odmnvv7m 252 7 - - HYPH cord-276616-odmnvv7m 252 8 K K NNP cord-276616-odmnvv7m 252 9 was be VBD cord-276616-odmnvv7m 252 10 really really RB cord-276616-odmnvv7m 252 11 accomplishing accomplish VBG cord-276616-odmnvv7m 252 12 , , , cord-276616-odmnvv7m 252 13 this this DT cord-276616-odmnvv7m 252 14 information information NN cord-276616-odmnvv7m 252 15 can can MD cord-276616-odmnvv7m 252 16 not not RB cord-276616-odmnvv7m 252 17 be be VB cord-276616-odmnvv7m 252 18 convincing convincing JJ cord-276616-odmnvv7m 252 19 . . . cord-276616-odmnvv7m 253 1 There there EX cord-276616-odmnvv7m 253 2 will will MD cord-276616-odmnvv7m 253 3 not not RB cord-276616-odmnvv7m 253 4 wittingly wittingly RB cord-276616-odmnvv7m 253 5 be be VB cord-276616-odmnvv7m 253 6 repeats repeat NNS cord-276616-odmnvv7m 253 7 , , , cord-276616-odmnvv7m 253 8 on on IN cord-276616-odmnvv7m 253 9 any any DT cord-276616-odmnvv7m 253 10 worthwhile worthwhile JJ cord-276616-odmnvv7m 253 11 scale scale NN cord-276616-odmnvv7m 253 12 , , , cord-276616-odmnvv7m 253 13 of of IN cord-276616-odmnvv7m 253 14 what what WP cord-276616-odmnvv7m 253 15 I -PRON- PRP cord-276616-odmnvv7m 253 16 have have VBP cord-276616-odmnvv7m 253 17 termed term VBN cord-276616-odmnvv7m 253 18 the the DT cord-276616-odmnvv7m 253 19 accidental accidental JJ cord-276616-odmnvv7m 253 20 ' ' `` cord-276616-odmnvv7m 253 21 experiments experiment NNS cord-276616-odmnvv7m 253 22 ' ' '' cord-276616-odmnvv7m 253 23 . . . cord-276616-odmnvv7m 254 1 Thus thus RB cord-276616-odmnvv7m 254 2 it -PRON- PRP cord-276616-odmnvv7m 254 3 is be VBZ cord-276616-odmnvv7m 254 4 useful useful JJ cord-276616-odmnvv7m 254 5 to to TO cord-276616-odmnvv7m 254 6 look look VB cord-276616-odmnvv7m 254 7 back back RB cord-276616-odmnvv7m 254 8 at at IN cord-276616-odmnvv7m 254 9 them -PRON- PRP cord-276616-odmnvv7m 254 10 and and CC cord-276616-odmnvv7m 254 11 see see VB cord-276616-odmnvv7m 254 12 whether whether IN cord-276616-odmnvv7m 254 13 any any DT cord-276616-odmnvv7m 254 14 information information NN cord-276616-odmnvv7m 254 15 was be VBD cord-276616-odmnvv7m 254 16 missed miss VBN cord-276616-odmnvv7m 254 17 in in IN cord-276616-odmnvv7m 254 18 the the DT cord-276616-odmnvv7m 254 19 earlier early JJR cord-276616-odmnvv7m 254 20 analysis analysis NN cord-276616-odmnvv7m 254 21 . . . cord-276616-odmnvv7m 255 1 The the DT cord-276616-odmnvv7m 255 2 louping louping NN cord-276616-odmnvv7m 255 3 - - HYPH cord-276616-odmnvv7m 255 4 ill ill JJ cord-276616-odmnvv7m 255 5 vaccination vaccination NN cord-276616-odmnvv7m 255 6 trial trial NN cord-276616-odmnvv7m 255 7 provided provide VBD cord-276616-odmnvv7m 255 8 much much JJ cord-276616-odmnvv7m 255 9 of of IN cord-276616-odmnvv7m 255 10 the the DT cord-276616-odmnvv7m 255 11 information information NN cord-276616-odmnvv7m 255 12 on on IN cord-276616-odmnvv7m 255 13 scrapie scrapie NN cord-276616-odmnvv7m 255 14 that that WDT cord-276616-odmnvv7m 255 15 we -PRON- PRP cord-276616-odmnvv7m 255 16 have have VBP cord-276616-odmnvv7m 255 17 today today NN cord-276616-odmnvv7m 255 18 : : : cord-276616-odmnvv7m 255 19 the the DT cord-276616-odmnvv7m 255 20 long long JJ cord-276616-odmnvv7m 255 21 latent latent JJ cord-276616-odmnvv7m 255 22 period period NN cord-276616-odmnvv7m 255 23 before before IN cord-276616-odmnvv7m 255 24 disease disease NN cord-276616-odmnvv7m 255 25 appears appear VBZ cord-276616-odmnvv7m 255 26 , , , cord-276616-odmnvv7m 255 27 the the DT cord-276616-odmnvv7m 255 28 resistance resistance NN cord-276616-odmnvv7m 255 29 of of IN cord-276616-odmnvv7m 255 30 the the DT cord-276616-odmnvv7m 255 31 agent agent NN cord-276616-odmnvv7m 255 32 and and CC cord-276616-odmnvv7m 255 33 the the DT cord-276616-odmnvv7m 255 34 resistance resistance NN cord-276616-odmnvv7m 255 35 of of IN cord-276616-odmnvv7m 255 36 much much JJ cord-276616-odmnvv7m 255 37 of of IN cord-276616-odmnvv7m 255 38 the the DT cord-276616-odmnvv7m 255 39 population population NN cord-276616-odmnvv7m 255 40 to to IN cord-276616-odmnvv7m 255 41 the the DT cord-276616-odmnvv7m 255 42 development development NN cord-276616-odmnvv7m 255 43 of of IN cord-276616-odmnvv7m 255 44 the the DT cord-276616-odmnvv7m 255 45 disease disease NN cord-276616-odmnvv7m 255 46 . . . cord-276616-odmnvv7m 256 1 Rather rather RB cord-276616-odmnvv7m 256 2 than than IN cord-276616-odmnvv7m 256 3 implicating implicate VBG cord-276616-odmnvv7m 256 4 the the DT cord-276616-odmnvv7m 256 5 acquisition acquisition NN cord-276616-odmnvv7m 256 6 of of IN cord-276616-odmnvv7m 256 7 infection infection NN cord-276616-odmnvv7m 256 8 by by IN cord-276616-odmnvv7m 256 9 ingestion ingestion NN cord-276616-odmnvv7m 256 10 of of IN cord-276616-odmnvv7m 256 11 ' ' `` cord-276616-odmnvv7m 256 12 contaminated contaminate VBN cord-276616-odmnvv7m 256 13 ' ' '' cord-276616-odmnvv7m 256 14 feed feed NN cord-276616-odmnvv7m 256 15 , , , cord-276616-odmnvv7m 256 16 that that DT cord-276616-odmnvv7m 256 17 event event NN cord-276616-odmnvv7m 256 18 directly directly RB cord-276616-odmnvv7m 256 19 implicated implicate VBD cord-276616-odmnvv7m 256 20 parenteral parenteral JJ cord-276616-odmnvv7m 256 21 ' ' `` cord-276616-odmnvv7m 256 22 infection infection NN cord-276616-odmnvv7m 256 23 ' ' '' cord-276616-odmnvv7m 256 24 . . . cord-276616-odmnvv7m 257 1 No no DT cord-276616-odmnvv7m 257 2 possibility possibility NN cord-276616-odmnvv7m 257 3 should should MD cord-276616-odmnvv7m 257 4 be be VB cord-276616-odmnvv7m 257 5 overlooked overlook VBN cord-276616-odmnvv7m 257 6 in in IN cord-276616-odmnvv7m 257 7 studies study NNS cord-276616-odmnvv7m 257 8 of of IN cord-276616-odmnvv7m 257 9 a a DT cord-276616-odmnvv7m 257 10 disease disease NN cord-276616-odmnvv7m 257 11 as as RB cord-276616-odmnvv7m 257 12 strange strange JJ cord-276616-odmnvv7m 257 13 as as IN cord-276616-odmnvv7m 257 14 scrapie scrapie NN cord-276616-odmnvv7m 257 15 . . . cord-276616-odmnvv7m 258 1 Even even RB cord-276616-odmnvv7m 258 2 though though IN cord-276616-odmnvv7m 258 3 louping loupe VBG cord-276616-odmnvv7m 258 4 - - HYPH cord-276616-odmnvv7m 258 5 ill ill JJ cord-276616-odmnvv7m 258 6 virus virus NN cord-276616-odmnvv7m 258 7 affects affect VBZ cord-276616-odmnvv7m 258 8 the the DT cord-276616-odmnvv7m 258 9 same same JJ cord-276616-odmnvv7m 258 10 areas area NNS cord-276616-odmnvv7m 258 11 of of IN cord-276616-odmnvv7m 258 12 the the DT cord-276616-odmnvv7m 258 13 nervous nervous JJ cord-276616-odmnvv7m 258 14 system system NN cord-276616-odmnvv7m 258 15 as as IN cord-276616-odmnvv7m 258 16 evidenced evidence VBN cord-276616-odmnvv7m 258 17 by by IN cord-276616-odmnvv7m 258 18 clinical clinical JJ cord-276616-odmnvv7m 258 19 signs sign NNS cord-276616-odmnvv7m 258 20 , , , cord-276616-odmnvv7m 258 21 inactivated inactivate VBN cord-276616-odmnvv7m 258 22 louping louping NN cord-276616-odmnvv7m 258 23 - - HYPH cord-276616-odmnvv7m 258 24 ill ill JJ cord-276616-odmnvv7m 258 25 virus virus NN cord-276616-odmnvv7m 258 26 seems seem VBZ cord-276616-odmnvv7m 258 27 to to TO cord-276616-odmnvv7m 258 28 have have VB cord-276616-odmnvv7m 258 29 been be VBN cord-276616-odmnvv7m 258 30 excluded exclude VBN cord-276616-odmnvv7m 258 31 as as IN cord-276616-odmnvv7m 258 32 a a DT cord-276616-odmnvv7m 258 33 contributing contribute VBG cord-276616-odmnvv7m 258 34 factor factor NN cord-276616-odmnvv7m 258 35 to to IN cord-276616-odmnvv7m 258 36 the the DT cord-276616-odmnvv7m 258 37 development development NN cord-276616-odmnvv7m 258 38 of of IN cord-276616-odmnvv7m 258 39 scrapie scrapie NN cord-276616-odmnvv7m 258 40 by by IN cord-276616-odmnvv7m 258 41 the the DT cord-276616-odmnvv7m 258 42 design design NN cord-276616-odmnvv7m 258 43 of of IN cord-276616-odmnvv7m 258 44 the the DT cord-276616-odmnvv7m 258 45 vaccination vaccination NN cord-276616-odmnvv7m 258 46 trials trial NNS cord-276616-odmnvv7m 258 47 . . . cord-276616-odmnvv7m 259 1 However however RB cord-276616-odmnvv7m 259 2 , , , cord-276616-odmnvv7m 259 3 the the DT cord-276616-odmnvv7m 259 4 possibility possibility NN cord-276616-odmnvv7m 259 5 that that IN cord-276616-odmnvv7m 259 6 the the DT cord-276616-odmnvv7m 259 7 injection injection NN cord-276616-odmnvv7m 259 8 of of IN cord-276616-odmnvv7m 259 9 a a DT cord-276616-odmnvv7m 259 10 killed kill VBN cord-276616-odmnvv7m 259 11 louping louping NN cord-276616-odmnvv7m 259 12 - - HYPH cord-276616-odmnvv7m 259 13 ill ill JJ cord-276616-odmnvv7m 259 14 virus virus NN cord-276616-odmnvv7m 259 15 can can MD cord-276616-odmnvv7m 259 16 potentiate potentiate VB cord-276616-odmnvv7m 259 17 infection infection NN cord-276616-odmnvv7m 259 18 of of IN cord-276616-odmnvv7m 259 19 the the DT cord-276616-odmnvv7m 259 20 scrapie scrapie NN cord-276616-odmnvv7m 259 21 agent agent NN cord-276616-odmnvv7m 259 22 deserves deserve VBZ cord-276616-odmnvv7m 259 23 further further JJ cord-276616-odmnvv7m 259 24 study study NN cord-276616-odmnvv7m 260 1 s. s. NNP cord-276616-odmnvv7m 260 2 Other other JJ cord-276616-odmnvv7m 260 3 controls control NNS cord-276616-odmnvv7m 260 4 in in IN cord-276616-odmnvv7m 260 5 attempting attempt VBG cord-276616-odmnvv7m 260 6 to to TO cord-276616-odmnvv7m 260 7 understand understand VB cord-276616-odmnvv7m 260 8 the the DT cord-276616-odmnvv7m 260 9 results result NNS cord-276616-odmnvv7m 260 10 of of IN cord-276616-odmnvv7m 260 11 the the DT cord-276616-odmnvv7m 260 12 vaccination vaccination NN cord-276616-odmnvv7m 260 13 trials trial NNS cord-276616-odmnvv7m 260 14 of of IN cord-276616-odmnvv7m 260 15 the the DT cord-276616-odmnvv7m 260 16 1930s 1930s CD cord-276616-odmnvv7m 260 17 could could MD cord-276616-odmnvv7m 260 18 be be VB cord-276616-odmnvv7m 260 19 to to TO cord-276616-odmnvv7m 260 20 examine examine VB cord-276616-odmnvv7m 260 21 brains brain NNS cord-276616-odmnvv7m 260 22 of of IN cord-276616-odmnvv7m 260 23 sheep sheep NN cord-276616-odmnvv7m 260 24 with with IN cord-276616-odmnvv7m 260 25 louping louping NN cord-276616-odmnvv7m 260 26 - - HYPH cord-276616-odmnvv7m 260 27 ill ill JJ cord-276616-odmnvv7m 260 28 for for IN cord-276616-odmnvv7m 260 29 the the DT cord-276616-odmnvv7m 260 30 presence presence NN cord-276616-odmnvv7m 260 31 of of IN cord-276616-odmnvv7m 260 32 protease protease NN cord-276616-odmnvv7m 260 33 resistant resistant JJ cord-276616-odmnvv7m 260 34 PrPSc prpsc NN cord-276616-odmnvv7m 260 35 and and CC cord-276616-odmnvv7m 260 36 also also RB cord-276616-odmnvv7m 260 37 to to TO cord-276616-odmnvv7m 260 38 test test VB cord-276616-odmnvv7m 260 39 the the DT cord-276616-odmnvv7m 260 40 sera sera NNP cord-276616-odmnvv7m 260 41 of of IN cord-276616-odmnvv7m 260 42 sheep sheep NNP cord-276616-odmnvv7m 260 43 used use VBN cord-276616-odmnvv7m 260 44 in in IN cord-276616-odmnvv7m 260 45 scrapie scrapie NN cord-276616-odmnvv7m 260 46 - - HYPH cord-276616-odmnvv7m 260 47 transmission transmission NN cord-276616-odmnvv7m 260 48 experiments experiment NNS cord-276616-odmnvv7m 260 49 for for IN cord-276616-odmnvv7m 260 50 antibodies antibody NNS cord-276616-odmnvv7m 260 51 to to IN cord-276616-odmnvv7m 260 52 a a DT cord-276616-odmnvv7m 260 53 wide wide JJ cord-276616-odmnvv7m 260 54 spectrum spectrum NN cord-276616-odmnvv7m 260 55 of of IN cord-276616-odmnvv7m 260 56 louping louping NN cord-276616-odmnvv7m 260 57 - - HYPH cord-276616-odmnvv7m 260 58 ill ill JJ cord-276616-odmnvv7m 260 59 virus virus NN cord-276616-odmnvv7m 260 60 isolates isolate NNS cord-276616-odmnvv7m 260 61 . . . cord-276616-odmnvv7m 261 1 While while IN cord-276616-odmnvv7m 261 2 the the DT cord-276616-odmnvv7m 261 3 above above JJ cord-276616-odmnvv7m 261 4 concerns concern NNS cord-276616-odmnvv7m 261 5 spread spread VBN cord-276616-odmnvv7m 261 6 of of IN cord-276616-odmnvv7m 261 7 scrapie scrapie NN cord-276616-odmnvv7m 261 8 by by IN cord-276616-odmnvv7m 261 9 parenteral parenteral JJ cord-276616-odmnvv7m 261 10 injection injection NN cord-276616-odmnvv7m 261 11 , , , cord-276616-odmnvv7m 261 12 there there EX cord-276616-odmnvv7m 261 13 has have VBZ cord-276616-odmnvv7m 261 14 been be VBN cord-276616-odmnvv7m 261 15 a a DT cord-276616-odmnvv7m 261 16 suggestion suggestion NN cord-276616-odmnvv7m 261 17 that that IN cord-276616-odmnvv7m 261 18 natural natural JJ cord-276616-odmnvv7m 261 19 transmission transmission NN cord-276616-odmnvv7m 261 20 may may MD cord-276616-odmnvv7m 261 21 occur occur VB cord-276616-odmnvv7m 261 22 from from IN cord-276616-odmnvv7m 261 23 sheep sheep NNS cord-276616-odmnvv7m 261 24 eating eat VBG cord-276616-odmnvv7m 261 25 dropped drop VBD cord-276616-odmnvv7m 261 26 placentae placentae NNP cord-276616-odmnvv7m 262 1 ( ( -LRB- cord-276616-odmnvv7m 262 2 Dickinson Dickinson NNP cord-276616-odmnvv7m 262 3 et et NNP cord-276616-odmnvv7m 262 4 al al NNP cord-276616-odmnvv7m 262 5 . . NNP cord-276616-odmnvv7m 262 6 , , , cord-276616-odmnvv7m 262 7 1974 1974 CD cord-276616-odmnvv7m 262 8 ) ) -RRB- cord-276616-odmnvv7m 262 9 , , . cord-276616-odmnvv7m 263 1 but but CC cord-276616-odmnvv7m 263 2 this this DT cord-276616-odmnvv7m 263 3 is be VBZ cord-276616-odmnvv7m 263 4 contraindicated contraindicate VBN cord-276616-odmnvv7m 263 5 by by IN cord-276616-odmnvv7m 263 6 the the DT cord-276616-odmnvv7m 263 7 fact fact NN cord-276616-odmnvv7m 263 8 that that IN cord-276616-odmnvv7m 263 9 ewes ewe NNS cord-276616-odmnvv7m 263 10 usually usually RB cord-276616-odmnvv7m 263 11 confine confine VBP cord-276616-odmnvv7m 263 12 themselves -PRON- PRP cord-276616-odmnvv7m 263 13 to to IN cord-276616-odmnvv7m 263 14 eating eat VBG cord-276616-odmnvv7m 263 15 their -PRON- PRP$ cord-276616-odmnvv7m 263 16 own own JJ cord-276616-odmnvv7m 263 17 placenta placenta NN cord-276616-odmnvv7m 263 18 . . . cord-276616-odmnvv7m 264 1 The the DT cord-276616-odmnvv7m 264 2 interpretation interpretation NN cord-276616-odmnvv7m 264 3 that that IN cord-276616-odmnvv7m 264 4 a a DT cord-276616-odmnvv7m 264 5 change change NN cord-276616-odmnvv7m 264 6 in in IN cord-276616-odmnvv7m 264 7 the the DT cord-276616-odmnvv7m 264 8 rendering rendering NN cord-276616-odmnvv7m 264 9 of of IN cord-276616-odmnvv7m 264 10 sheep sheep NN cord-276616-odmnvv7m 264 11 offal offal NN cord-276616-odmnvv7m 264 12 led lead VBD cord-276616-odmnvv7m 264 13 to to IN cord-276616-odmnvv7m 264 14 the the DT cord-276616-odmnvv7m 264 15 outbreak outbreak NN cord-276616-odmnvv7m 264 16 of of IN cord-276616-odmnvv7m 264 17 BSE BSE NNP cord-276616-odmnvv7m 264 18 is be VBZ cord-276616-odmnvv7m 264 19 based base VBN cord-276616-odmnvv7m 264 20 on on IN cord-276616-odmnvv7m 264 21 statistical statistical JJ cord-276616-odmnvv7m 264 22 evidence evidence NN cord-276616-odmnvv7m 264 23 and and CC cord-276616-odmnvv7m 264 24 on on IN cord-276616-odmnvv7m 264 25 the the DT cord-276616-odmnvv7m 264 26 conclusion conclusion NN cord-276616-odmnvv7m 264 27 that that IN cord-276616-odmnvv7m 264 28 , , , cord-276616-odmnvv7m 264 29 in in IN cord-276616-odmnvv7m 264 30 the the DT cord-276616-odmnvv7m 264 31 circumstances circumstance NNS cord-276616-odmnvv7m 264 32 at at IN cord-276616-odmnvv7m 264 33 the the DT cord-276616-odmnvv7m 264 34 time time NN cord-276616-odmnvv7m 264 35 , , , cord-276616-odmnvv7m 264 36 no no DT cord-276616-odmnvv7m 264 37 other other JJ cord-276616-odmnvv7m 264 38 explanation explanation NN cord-276616-odmnvv7m 264 39 was be VBD cord-276616-odmnvv7m 264 40 possible possible JJ cord-276616-odmnvv7m 264 41 . . . cord-276616-odmnvv7m 265 1 It -PRON- PRP cord-276616-odmnvv7m 265 2 was be VBD cord-276616-odmnvv7m 265 3 also also RB cord-276616-odmnvv7m 265 4 an an DT cord-276616-odmnvv7m 265 5 explanation explanation NN cord-276616-odmnvv7m 265 6 that that WDT cord-276616-odmnvv7m 265 7 could could MD cord-276616-odmnvv7m 265 8 be be VB cord-276616-odmnvv7m 265 9 adopted adopt VBN cord-276616-odmnvv7m 265 10 for for IN cord-276616-odmnvv7m 265 11 political political JJ cord-276616-odmnvv7m 265 12 reasons reason NNS cord-276616-odmnvv7m 265 13 and and CC cord-276616-odmnvv7m 265 14 gave give VBD cord-276616-odmnvv7m 265 15 some some DT cord-276616-odmnvv7m 265 16 justification justification NN cord-276616-odmnvv7m 265 17 for for IN cord-276616-odmnvv7m 265 18 the the DT cord-276616-odmnvv7m 265 19 control control NN cord-276616-odmnvv7m 265 20 procedures procedure NNS cord-276616-odmnvv7m 265 21 that that WDT cord-276616-odmnvv7m 265 22 were be VBD cord-276616-odmnvv7m 265 23 adopted adopt VBN cord-276616-odmnvv7m 265 24 for for IN cord-276616-odmnvv7m 265 25 controlling control VBG cord-276616-odmnvv7m 265 26 BSE BSE NNP cord-276616-odmnvv7m 265 27 . . . cord-276616-odmnvv7m 266 1 However however RB cord-276616-odmnvv7m 266 2 , , , cord-276616-odmnvv7m 266 3 it -PRON- PRP cord-276616-odmnvv7m 266 4 has have VBZ cord-276616-odmnvv7m 266 5 been be VBN cord-276616-odmnvv7m 266 6 pointed point VBN cord-276616-odmnvv7m 266 7 out out RP cord-276616-odmnvv7m 266 8 that that IN cord-276616-odmnvv7m 266 9 the the DT cord-276616-odmnvv7m 266 10 human human JJ cord-276616-odmnvv7m 266 11 risk risk NN cord-276616-odmnvv7m 266 12 from from IN cord-276616-odmnvv7m 266 13 eating eat VBG cord-276616-odmnvv7m 266 14 mutton mutton NN cord-276616-odmnvv7m 266 15 and and CC cord-276616-odmnvv7m 266 16 lamb lamb NN cord-276616-odmnvv7m 266 17 must must MD cord-276616-odmnvv7m 266 18 be be VB cord-276616-odmnvv7m 266 19 negligible negligible JJ cord-276616-odmnvv7m 266 20 since since RB cord-276616-odmnvv7m 266 21 , , , cord-276616-odmnvv7m 266 22 in in IN cord-276616-odmnvv7m 266 23 a a DT cord-276616-odmnvv7m 266 24 country country NN cord-276616-odmnvv7m 266 25 where where WRB cord-276616-odmnvv7m 266 26 scrapie scrapie NN cord-276616-odmnvv7m 266 27 occurs occur VBZ cord-276616-odmnvv7m 266 28 as as IN cord-276616-odmnvv7m 266 29 a a DT cord-276616-odmnvv7m 266 30 disease disease NN cord-276616-odmnvv7m 266 31 and and CC cord-276616-odmnvv7m 266 32 where where WRB cord-276616-odmnvv7m 266 33 this this DT cord-276616-odmnvv7m 266 34 meat meat NN cord-276616-odmnvv7m 266 35 has have VBZ cord-276616-odmnvv7m 266 36 been be VBN cord-276616-odmnvv7m 266 37 eaten eat VBN cord-276616-odmnvv7m 266 38 for for IN cord-276616-odmnvv7m 266 39 a a DT cord-276616-odmnvv7m 266 40 very very RB cord-276616-odmnvv7m 266 41 long long JJ cord-276616-odmnvv7m 266 42 time time NN cord-276616-odmnvv7m 266 43 , , , cord-276616-odmnvv7m 266 44 the the DT cord-276616-odmnvv7m 266 45 incidence incidence NN cord-276616-odmnvv7m 266 46 of of IN cord-276616-odmnvv7m 266 47 encephalopathies encephalopathy NNS cord-276616-odmnvv7m 266 48 , , , cord-276616-odmnvv7m 266 49 such such JJ cord-276616-odmnvv7m 266 50 as as IN cord-276616-odmnvv7m 266 51 CJD CJD NNP cord-276616-odmnvv7m 266 52 , , , cord-276616-odmnvv7m 266 53 that that WDT cord-276616-odmnvv7m 266 54 might may MD cord-276616-odmnvv7m 266 55 be be VB cord-276616-odmnvv7m 266 56 expected expect VBN cord-276616-odmnvv7m 266 57 to to TO cord-276616-odmnvv7m 266 58 follow follow VB cord-276616-odmnvv7m 266 59 , , , cord-276616-odmnvv7m 266 60 is be VBZ cord-276616-odmnvv7m 266 61 actually actually RB cord-276616-odmnvv7m 266 62 very very RB cord-276616-odmnvv7m 266 63 low low JJ cord-276616-odmnvv7m 266 64 ( ( -LRB- cord-276616-odmnvv7m 266 65 0.49 0.49 CD cord-276616-odmnvv7m 266 66 cases case NNS cord-276616-odmnvv7m 266 67 per per IN cord-276616-odmnvv7m 266 68 million million CD cord-276616-odmnvv7m 266 69 ) ) -RRB- cord-276616-odmnvv7m 267 1 ( ( -LRB- cord-276616-odmnvv7m 267 2 Mathews Mathews NNP cord-276616-odmnvv7m 267 3 , , , cord-276616-odmnvv7m 267 4 1990 1990 CD cord-276616-odmnvv7m 267 5 ) ) -RRB- cord-276616-odmnvv7m 267 6 . . . cord-276616-odmnvv7m 268 1 Finally finally RB cord-276616-odmnvv7m 268 2 , , , cord-276616-odmnvv7m 268 3 despite despite IN cord-276616-odmnvv7m 268 4 earlier early JJR cord-276616-odmnvv7m 268 5 concerns concern NNS cord-276616-odmnvv7m 268 6 , , , cord-276616-odmnvv7m 268 7 a a DT cord-276616-odmnvv7m 268 8 connection connection NN cord-276616-odmnvv7m 268 9 between between IN cord-276616-odmnvv7m 268 10 the the DT cord-276616-odmnvv7m 268 11 feeding feeding NN cord-276616-odmnvv7m 268 12 of of IN cord-276616-odmnvv7m 268 13 sheep sheep NN cord-276616-odmnvv7m 268 14 offal offal NN cord-276616-odmnvv7m 268 15 and and CC cord-276616-odmnvv7m 268 16 the the DT cord-276616-odmnvv7m 268 17 incidence incidence NN cord-276616-odmnvv7m 268 18 of of IN cord-276616-odmnvv7m 268 19 TME TME NNP cord-276616-odmnvv7m 268 20 has have VBZ cord-276616-odmnvv7m 268 21 not not RB cord-276616-odmnvv7m 268 22 been be VBN cord-276616-odmnvv7m 268 23 proven prove VBN cord-276616-odmnvv7m 268 24 ( ( -LRB- cord-276616-odmnvv7m 268 25 see see VB cord-276616-odmnvv7m 268 26 above above RB cord-276616-odmnvv7m 268 27 ) ) -RRB- cord-276616-odmnvv7m 268 28 . . . cord-276616-odmnvv7m 269 1 Avery Avery NNP cord-276616-odmnvv7m 269 2 and and CC cord-276616-odmnvv7m 269 3 colleagues colleague NNS cord-276616-odmnvv7m 269 4 ( ( -LRB- cord-276616-odmnvv7m 269 5 1960 1960 CD cord-276616-odmnvv7m 269 6 ) ) -RRB- cord-276616-odmnvv7m 269 7 considered consider VBD cord-276616-odmnvv7m 269 8 that that IN cord-276616-odmnvv7m 269 9 , , , cord-276616-odmnvv7m 269 10 if if IN cord-276616-odmnvv7m 269 11 scrapie scrapie NN cord-276616-odmnvv7m 269 12 were be VBD cord-276616-odmnvv7m 269 13 a a DT cord-276616-odmnvv7m 269 14 chronic chronic JJ cord-276616-odmnvv7m 269 15 disease disease NN cord-276616-odmnvv7m 269 16 caused cause VBN cord-276616-odmnvv7m 269 17 by by IN cord-276616-odmnvv7m 269 18 an an DT cord-276616-odmnvv7m 269 19 infective infective JJ cord-276616-odmnvv7m 269 20 agent agent NN cord-276616-odmnvv7m 269 21 , , , cord-276616-odmnvv7m 269 22 the the DT cord-276616-odmnvv7m 269 23 level level NN cord-276616-odmnvv7m 269 24 of of IN cord-276616-odmnvv7m 269 25 gamma gamma NN cord-276616-odmnvv7m 269 26 - - HYPH cord-276616-odmnvv7m 269 27 globufin globufin NNP cord-276616-odmnvv7m 269 28 , , , cord-276616-odmnvv7m 269 29 the the DT cord-276616-odmnvv7m 269 30 serum serum NN cord-276616-odmnvv7m 269 31 protein protein NN cord-276616-odmnvv7m 269 32 fraction fraction NN cord-276616-odmnvv7m 269 33 containing contain VBG cord-276616-odmnvv7m 269 34 antibody antibody NN cord-276616-odmnvv7m 269 35 , , , cord-276616-odmnvv7m 269 36 might may MD cord-276616-odmnvv7m 269 37 well well RB cord-276616-odmnvv7m 269 38 be be VB cord-276616-odmnvv7m 269 39 raised raise VBN cord-276616-odmnvv7m 269 40 . . . cord-276616-odmnvv7m 270 1 Unfortunately unfortunately RB cord-276616-odmnvv7m 270 2 , , , cord-276616-odmnvv7m 270 3 the the DT cord-276616-odmnvv7m 270 4 electrophoretic electrophoretic JJ cord-276616-odmnvv7m 270 5 patterns pattern NNS cord-276616-odmnvv7m 270 6 were be VBD cord-276616-odmnvv7m 270 7 similar similar JJ cord-276616-odmnvv7m 270 8 for for IN cord-276616-odmnvv7m 270 9 the the DT cord-276616-odmnvv7m 270 10 sera sera NNP cord-276616-odmnvv7m 270 11 of of IN cord-276616-odmnvv7m 270 12 both both CC cord-276616-odmnvv7m 270 13 normal normal JJ cord-276616-odmnvv7m 270 14 and and CC cord-276616-odmnvv7m 270 15 scrapie scrapie NN cord-276616-odmnvv7m 270 16 - - HYPH cord-276616-odmnvv7m 270 17 affected affect VBN cord-276616-odmnvv7m 270 18 animals animal NNS cord-276616-odmnvv7m 270 19 . . . cord-276616-odmnvv7m 271 1 Nevertheless nevertheless RB cord-276616-odmnvv7m 271 2 , , , cord-276616-odmnvv7m 271 3 despite despite IN cord-276616-odmnvv7m 271 4 the the DT cord-276616-odmnvv7m 271 5 ' ' `` cord-276616-odmnvv7m 271 6 rather rather RB cord-276616-odmnvv7m 271 7 overwhelming overwhelming JJ cord-276616-odmnvv7m 271 8 evidence evidence NN cord-276616-odmnvv7m 271 9 for for IN cord-276616-odmnvv7m 271 10 " " `` cord-276616-odmnvv7m 271 11 immunological immunological JJ cord-276616-odmnvv7m 271 12 silence silence NN cord-276616-odmnvv7m 271 13 " " '' cord-276616-odmnvv7m 271 14 ' ' '' cord-276616-odmnvv7m 271 15 in in IN cord-276616-odmnvv7m 271 16 scrapie scrapie NN cord-276616-odmnvv7m 271 17 , , , cord-276616-odmnvv7m 271 18 Stites Stites NNPS cord-276616-odmnvv7m 271 19 and and CC cord-276616-odmnvv7m 271 20 colleagues colleague NNS cord-276616-odmnvv7m 271 21 ( ( -LRB- cord-276616-odmnvv7m 271 22 1979 1979 CD cord-276616-odmnvv7m 271 23 ) ) -RRB- cord-276616-odmnvv7m 271 24 advanced advance VBD cord-276616-odmnvv7m 271 25 some some DT cord-276616-odmnvv7m 271 26 evidence evidence NN cord-276616-odmnvv7m 271 27 for for IN cord-276616-odmnvv7m 271 28 the the DT cord-276616-odmnvv7m 271 29 development development NN cord-276616-odmnvv7m 271 30 of of IN cord-276616-odmnvv7m 271 31 an an DT cord-276616-odmnvv7m 271 32 immunological immunological JJ cord-276616-odmnvv7m 271 33 response response NN cord-276616-odmnvv7m 271 34 . . . cord-276616-odmnvv7m 272 1 They -PRON- PRP cord-276616-odmnvv7m 272 2 stressed stress VBD cord-276616-odmnvv7m 272 3 that that IN cord-276616-odmnvv7m 272 4 the the DT cord-276616-odmnvv7m 272 5 lack lack NN cord-276616-odmnvv7m 272 6 of of IN cord-276616-odmnvv7m 272 7 detection detection NN cord-276616-odmnvv7m 272 8 of of IN cord-276616-odmnvv7m 272 9 an an DT cord-276616-odmnvv7m 272 10 immune immune JJ cord-276616-odmnvv7m 272 11 response response NN cord-276616-odmnvv7m 272 12 does do VBZ cord-276616-odmnvv7m 272 13 not not RB cord-276616-odmnvv7m 272 14 convincingly convincingly RB cord-276616-odmnvv7m 272 15 disprove disprove VB cord-276616-odmnvv7m 272 16 its -PRON- PRP$ cord-276616-odmnvv7m 272 17 existence existence NN cord-276616-odmnvv7m 272 18 . . . cord-276616-odmnvv7m 273 1 Whatever whatever WDT cord-276616-odmnvv7m 273 2 the the DT cord-276616-odmnvv7m 273 3 causal causal JJ cord-276616-odmnvv7m 273 4 agent agent NN cord-276616-odmnvv7m 273 5 , , , cord-276616-odmnvv7m 273 6 if if IN cord-276616-odmnvv7m 273 7 its -PRON- PRP$ cord-276616-odmnvv7m 273 8 tropism tropism NN cord-276616-odmnvv7m 273 9 were be VBD cord-276616-odmnvv7m 273 10 entirely entirely RB cord-276616-odmnvv7m 273 11 neural neural JJ cord-276616-odmnvv7m 273 12 , , , cord-276616-odmnvv7m 273 13 then then RB cord-276616-odmnvv7m 273 14 insufficient insufficient JJ cord-276616-odmnvv7m 273 15 agent agent NN cord-276616-odmnvv7m 273 16 might may MD cord-276616-odmnvv7m 273 17 reach reach VB cord-276616-odmnvv7m 273 18 the the DT cord-276616-odmnvv7m 273 19 blood blood NN cord-276616-odmnvv7m 273 20 stream stream NN cord-276616-odmnvv7m 273 21 to to TO cord-276616-odmnvv7m 273 22 lead lead VB cord-276616-odmnvv7m 273 23 to to IN cord-276616-odmnvv7m 273 24 an an DT cord-276616-odmnvv7m 273 25 immunological immunological JJ cord-276616-odmnvv7m 273 26 response response NN cord-276616-odmnvv7m 273 27 . . . cord-276616-odmnvv7m 274 1 This this DT cord-276616-odmnvv7m 274 2 explanation explanation NN cord-276616-odmnvv7m 274 3 appears appear VBZ cord-276616-odmnvv7m 274 4 weak weak JJ cord-276616-odmnvv7m 274 5 , , , cord-276616-odmnvv7m 274 6 but but CC cord-276616-odmnvv7m 274 7 another another DT cord-276616-odmnvv7m 274 8 possible possible JJ cord-276616-odmnvv7m 274 9 explanation explanation NN cord-276616-odmnvv7m 274 10 is be VBZ cord-276616-odmnvv7m 274 11 that that IN cord-276616-odmnvv7m 274 12 SAF SAF NNP cord-276616-odmnvv7m 274 13 is be VBZ cord-276616-odmnvv7m 274 14 too too RB cord-276616-odmnvv7m 274 15 close close JJ cord-276616-odmnvv7m 274 16 to to IN cord-276616-odmnvv7m 274 17 its -PRON- PRP$ cord-276616-odmnvv7m 274 18 equivalent equivalent NN cord-276616-odmnvv7m 274 19 produced produce VBN cord-276616-odmnvv7m 274 20 by by IN cord-276616-odmnvv7m 274 21 the the DT cord-276616-odmnvv7m 274 22 PrP prp NN cord-276616-odmnvv7m 274 23 gene gene NN cord-276616-odmnvv7m 274 24 of of IN cord-276616-odmnvv7m 274 25 normal normal JJ cord-276616-odmnvv7m 274 26 animals animal NNS cord-276616-odmnvv7m 274 27 to to TO cord-276616-odmnvv7m 274 28 give give VB cord-276616-odmnvv7m 274 29 a a DT cord-276616-odmnvv7m 274 30 response response NN cord-276616-odmnvv7m 274 31 , , , cord-276616-odmnvv7m 274 32 although although IN cord-276616-odmnvv7m 274 33 it -PRON- PRP cord-276616-odmnvv7m 274 34 would would MD cord-276616-odmnvv7m 274 35 be be VB cord-276616-odmnvv7m 274 36 expected expect VBN cord-276616-odmnvv7m 274 37 that that IN cord-276616-odmnvv7m 274 38 even even RB cord-276616-odmnvv7m 274 39 a a DT cord-276616-odmnvv7m 274 40 small small JJ cord-276616-odmnvv7m 274 41 difference difference NN cord-276616-odmnvv7m 274 42 would would MD cord-276616-odmnvv7m 274 43 lead lead VB cord-276616-odmnvv7m 274 44 to to IN cord-276616-odmnvv7m 274 45 the the DT cord-276616-odmnvv7m 274 46 production production NN cord-276616-odmnvv7m 274 47 of of IN cord-276616-odmnvv7m 274 48 recognizable recognizable JJ cord-276616-odmnvv7m 274 49 antibody antibody NN cord-276616-odmnvv7m 274 50 . . . cord-276616-odmnvv7m 275 1 A a DT cord-276616-odmnvv7m 275 2 more more RBR cord-276616-odmnvv7m 275 3 direct direct JJ cord-276616-odmnvv7m 275 4 immunological immunological JJ cord-276616-odmnvv7m 275 5 approach approach NN cord-276616-odmnvv7m 275 6 would would MD cord-276616-odmnvv7m 275 7 be be VB cord-276616-odmnvv7m 275 8 to to TO cord-276616-odmnvv7m 275 9 look look VB cord-276616-odmnvv7m 275 10 for for IN cord-276616-odmnvv7m 275 11 antibody antibody NN cord-276616-odmnvv7m 275 12 to to IN cord-276616-odmnvv7m 275 13 other other JJ cord-276616-odmnvv7m 275 14 disease disease NN cord-276616-odmnvv7m 275 15 entities entity NNS cord-276616-odmnvv7m 275 16 ; ; : cord-276616-odmnvv7m 275 17 for for IN cord-276616-odmnvv7m 275 18 example example NN cord-276616-odmnvv7m 275 19 , , , cord-276616-odmnvv7m 275 20 with with IN cord-276616-odmnvv7m 275 21 what what WDT cord-276616-odmnvv7m 275 22 frequency frequency NN cord-276616-odmnvv7m 275 23 are be VBP cord-276616-odmnvv7m 275 24 antibodies antibody NNS cord-276616-odmnvv7m 275 25 to to IN cord-276616-odmnvv7m 275 26 BLV BLV NNP cord-276616-odmnvv7m 275 27 encountered encounter VBN cord-276616-odmnvv7m 275 28 in in IN cord-276616-odmnvv7m 275 29 cattle cattle NNS cord-276616-odmnvv7m 275 30 in in IN cord-276616-odmnvv7m 275 31 cases case NNS cord-276616-odmnvv7m 275 32 of of IN cord-276616-odmnvv7m 275 33 BSE BSE NNP cord-276616-odmnvv7m 275 34 ? ? . cord-276616-odmnvv7m 276 1 with with IN cord-276616-odmnvv7m 276 2 what what WDT cord-276616-odmnvv7m 276 3 frequency frequency NN cord-276616-odmnvv7m 276 4 are be VBP cord-276616-odmnvv7m 276 5 maedi maedi JJ cord-276616-odmnvv7m 276 6 - - HYPH cord-276616-odmnvv7m 276 7 visna visna NN cord-276616-odmnvv7m 276 8 antibodies antibody NNS cord-276616-odmnvv7m 276 9 encountered encounter VBN cord-276616-odmnvv7m 276 10 in in IN cord-276616-odmnvv7m 276 11 sheep sheep NN cord-276616-odmnvv7m 276 12 with with IN cord-276616-odmnvv7m 276 13 scrapie scrapie NN cord-276616-odmnvv7m 276 14 ? ? . cord-276616-odmnvv7m 277 1 These these DT cord-276616-odmnvv7m 277 2 viruses virus NNS cord-276616-odmnvv7m 277 3 are be VBP cord-276616-odmnvv7m 277 4 quite quite RB cord-276616-odmnvv7m 277 5 prevalent prevalent JJ cord-276616-odmnvv7m 277 6 in in IN cord-276616-odmnvv7m 277 7 dairy dairy NN cord-276616-odmnvv7m 277 8 cattle cattle NNS cord-276616-odmnvv7m 277 9 and and CC cord-276616-odmnvv7m 277 10 in in IN cord-276616-odmnvv7m 277 11 sheep sheep NNS cord-276616-odmnvv7m 277 12 , , , cord-276616-odmnvv7m 277 13 respectively respectively RB cord-276616-odmnvv7m 277 14 , , , cord-276616-odmnvv7m 277 15 and and CC cord-276616-odmnvv7m 277 16 are be VBP cord-276616-odmnvv7m 277 17 slow slow JJ cord-276616-odmnvv7m 277 18 viruses virus NNS cord-276616-odmnvv7m 277 19 in in IN cord-276616-odmnvv7m 277 20 their -PRON- PRP$ cord-276616-odmnvv7m 277 21 own own JJ cord-276616-odmnvv7m 277 22 right right NN cord-276616-odmnvv7m 277 23 . . . cord-276616-odmnvv7m 278 1 Both both DT cord-276616-odmnvv7m 278 2 viruses virus NNS cord-276616-odmnvv7m 278 3 have have VBP cord-276616-odmnvv7m 278 4 a a DT cord-276616-odmnvv7m 278 5 DNA dna NN cord-276616-odmnvv7m 278 6 phase phase NN cord-276616-odmnvv7m 278 7 and and CC cord-276616-odmnvv7m 278 8 could could MD cord-276616-odmnvv7m 278 9 well well RB cord-276616-odmnvv7m 278 10 have have VB cord-276616-odmnvv7m 278 11 an an DT cord-276616-odmnvv7m 278 12 association association NN cord-276616-odmnvv7m 278 13 with with IN cord-276616-odmnvv7m 278 14 genes gene NNS cord-276616-odmnvv7m 278 15 for for IN cord-276616-odmnvv7m 278 16 both both DT cord-276616-odmnvv7m 278 17 susceptibility susceptibility NN cord-276616-odmnvv7m 278 18 to to IN cord-276616-odmnvv7m 278 19 the the DT cord-276616-odmnvv7m 278 20 encephalopathies encephalopathy NNS cord-276616-odmnvv7m 278 21 and and CC cord-276616-odmnvv7m 278 22 amyloidal amyloidal NNP cord-276616-odmnvv7m 278 23 fibrin fibrin NN cord-276616-odmnvv7m 278 24 formation formation NN cord-276616-odmnvv7m 278 25 . . . cord-276616-odmnvv7m 279 1 Antibodies antibody NNS cord-276616-odmnvv7m 279 2 to to IN cord-276616-odmnvv7m 279 3 hepadnaviruses hepadnavirus NNS cord-276616-odmnvv7m 279 4 , , , cord-276616-odmnvv7m 279 5 to to IN cord-276616-odmnvv7m 279 6 MCF MCF NNP cord-276616-odmnvv7m 279 7 viruses virus NNS cord-276616-odmnvv7m 279 8 and and CC cord-276616-odmnvv7m 279 9 to to IN cord-276616-odmnvv7m 279 10 spiroplasma spiroplasma NNP cord-276616-odmnvv7m 279 11 should should MD cord-276616-odmnvv7m 279 12 also also RB cord-276616-odmnvv7m 279 13 be be VB cord-276616-odmnvv7m 279 14 sought seek VBN cord-276616-odmnvv7m 279 15 . . . cord-276616-odmnvv7m 280 1 Unless unless IN cord-276616-odmnvv7m 280 2 there there EX cord-276616-odmnvv7m 280 3 were be VBD cord-276616-odmnvv7m 280 4 an an DT cord-276616-odmnvv7m 280 5 associated associate VBN cord-276616-odmnvv7m 280 6 immunodeficiency immunodeficiency NN cord-276616-odmnvv7m 280 7 , , , cord-276616-odmnvv7m 280 8 the the DT cord-276616-odmnvv7m 280 9 absence absence NN cord-276616-odmnvv7m 280 10 of of IN cord-276616-odmnvv7m 280 11 detectable detectable JJ cord-276616-odmnvv7m 280 12 antibody antibody NN cord-276616-odmnvv7m 280 13 to to IN cord-276616-odmnvv7m 280 14 these these DT cord-276616-odmnvv7m 280 15 agents agent NNS cord-276616-odmnvv7m 280 16 would would MD cord-276616-odmnvv7m 280 17 largely largely RB cord-276616-odmnvv7m 280 18 remove remove VB cord-276616-odmnvv7m 280 19 them -PRON- PRP cord-276616-odmnvv7m 280 20 from from IN cord-276616-odmnvv7m 280 21 consideration consideration NN cord-276616-odmnvv7m 280 22 as as IN cord-276616-odmnvv7m 280 23 having have VBG cord-276616-odmnvv7m 280 24 primary primary JJ cord-276616-odmnvv7m 280 25 or or CC cord-276616-odmnvv7m 280 26 secondary secondary JJ cord-276616-odmnvv7m 280 27 roles role NNS cord-276616-odmnvv7m 280 28 in in IN cord-276616-odmnvv7m 280 29 the the DT cord-276616-odmnvv7m 280 30 causation causation NN cord-276616-odmnvv7m 280 31 of of IN cord-276616-odmnvv7m 280 32 the the DT cord-276616-odmnvv7m 280 33 spongiform spongiform JJ cord-276616-odmnvv7m 280 34 encephalopathies encephalopathy NNS cord-276616-odmnvv7m 280 35 . . . cord-276616-odmnvv7m 281 1 Evidence evidence NN cord-276616-odmnvv7m 281 2 of of IN cord-276616-odmnvv7m 281 3 an an DT cord-276616-odmnvv7m 281 4 immunological immunological JJ cord-276616-odmnvv7m 281 5 deficiency deficiency NN cord-276616-odmnvv7m 281 6 should should MD cord-276616-odmnvv7m 281 7 also also RB cord-276616-odmnvv7m 281 8 be be VB cord-276616-odmnvv7m 281 9 sought seek VBN cord-276616-odmnvv7m 281 10 using use VBG cord-276616-odmnvv7m 281 11 current current JJ cord-276616-odmnvv7m 281 12 technology technology NN cord-276616-odmnvv7m 281 13 similar similar JJ cord-276616-odmnvv7m 281 14 to to IN cord-276616-odmnvv7m 281 15 that that DT cord-276616-odmnvv7m 281 16 used use VBN cord-276616-odmnvv7m 281 17 by by IN cord-276616-odmnvv7m 281 18 Rao Rao NNP cord-276616-odmnvv7m 281 19 and and CC cord-276616-odmnvv7m 281 20 colleagues colleague NNS cord-276616-odmnvv7m 281 21 ( ( -LRB- cord-276616-odmnvv7m 281 22 1990 1990 CD cord-276616-odmnvv7m 281 23 ) ) -RRB- cord-276616-odmnvv7m 281 24 to to TO cord-276616-odmnvv7m 281 25 study study VB cord-276616-odmnvv7m 281 26 the the DT cord-276616-odmnvv7m 281 27 immune immune JJ cord-276616-odmnvv7m 281 28 deficiency deficiency NN cord-276616-odmnvv7m 281 29 produced produce VBN cord-276616-odmnvv7m 281 30 by by IN cord-276616-odmnvv7m 281 31 the the DT cord-276616-odmnvv7m 281 32 avian avian JJ cord-276616-odmnvv7m 281 33 retrovirus retrovirus NN cord-276616-odmnvv7m 281 34 , , , cord-276616-odmnvv7m 281 35 avian avian JJ cord-276616-odmnvv7m 281 36 erythroblastosis erythroblastosis NN cord-276616-odmnvv7m 281 37 virus virus NN cord-276616-odmnvv7m 281 38 . . . cord-276616-odmnvv7m 282 1 Stites stite NNS cord-276616-odmnvv7m 282 2 and and CC cord-276616-odmnvv7m 282 3 colleagues colleague NNS cord-276616-odmnvv7m 282 4 ( ( -LRB- cord-276616-odmnvv7m 282 5 1979 1979 CD cord-276616-odmnvv7m 282 6 ) ) -RRB- cord-276616-odmnvv7m 282 7 affirmed affirm VBD cord-276616-odmnvv7m 282 8 that that IN cord-276616-odmnvv7m 282 9 current current JJ cord-276616-odmnvv7m 282 10 information information NN cord-276616-odmnvv7m 282 11 could could MD cord-276616-odmnvv7m 282 12 accommodate accommodate VB cord-276616-odmnvv7m 282 13 the the DT cord-276616-odmnvv7m 282 14 possibility possibility NN cord-276616-odmnvv7m 282 15 that that IN cord-276616-odmnvv7m 282 16 negative negative JJ cord-276616-odmnvv7m 282 17 regulation regulation NN cord-276616-odmnvv7m 282 18 or or CC cord-276616-odmnvv7m 282 19 active active JJ cord-276616-odmnvv7m 282 20 immunosuppression immunosuppression NN cord-276616-odmnvv7m 282 21 play play VBP cord-276616-odmnvv7m 282 22 an an DT cord-276616-odmnvv7m 282 23 important important JJ cord-276616-odmnvv7m 282 24 role role NN cord-276616-odmnvv7m 282 25 in in IN cord-276616-odmnvv7m 282 26 the the DT cord-276616-odmnvv7m 282 27 pathogenesis pathogenesis NN cord-276616-odmnvv7m 282 28 of of IN cord-276616-odmnvv7m 282 29 scrapie scrapie NN cord-276616-odmnvv7m 282 30 . . . cord-276616-odmnvv7m 283 1 They -PRON- PRP cord-276616-odmnvv7m 283 2 noted note VBD cord-276616-odmnvv7m 283 3 that that IN cord-276616-odmnvv7m 283 4 mice mouse NNS cord-276616-odmnvv7m 283 5 show show VBP cord-276616-odmnvv7m 283 6 a a DT cord-276616-odmnvv7m 283 7 distinct distinct JJ cord-276616-odmnvv7m 283 8 splenomegaly splenomegaly NN cord-276616-odmnvv7m 283 9 after after IN cord-276616-odmnvv7m 283 10 intracerebral intracerebral JJ cord-276616-odmnvv7m 283 11 inoculation inoculation NN cord-276616-odmnvv7m 283 12 with with IN cord-276616-odmnvv7m 283 13 the the DT cord-276616-odmnvv7m 283 14 agent agent NN cord-276616-odmnvv7m 283 15 , , , cord-276616-odmnvv7m 283 16 that that IN cord-276616-odmnvv7m 283 17 the the DT cord-276616-odmnvv7m 283 18 agent agent NN cord-276616-odmnvv7m 283 19 at at IN cord-276616-odmnvv7m 283 20 first first RB cord-276616-odmnvv7m 283 21 appears appear VBZ cord-276616-odmnvv7m 283 22 in in IN cord-276616-odmnvv7m 283 23 higher high JJR cord-276616-odmnvv7m 283 24 concentrations concentration NNS cord-276616-odmnvv7m 283 25 in in IN cord-276616-odmnvv7m 283 26 the the DT cord-276616-odmnvv7m 283 27 spleen spleen NN cord-276616-odmnvv7m 283 28 than than IN cord-276616-odmnvv7m 283 29 in in IN cord-276616-odmnvv7m 283 30 the the DT cord-276616-odmnvv7m 283 31 brain brain NN cord-276616-odmnvv7m 283 32 , , , cord-276616-odmnvv7m 283 33 and and CC cord-276616-odmnvv7m 283 34 that that IN cord-276616-odmnvv7m 283 35 splenectomy splenectomy NN cord-276616-odmnvv7m 283 36 prolongs prolong VBZ cord-276616-odmnvv7m 283 37 the the DT cord-276616-odmnvv7m 283 38 incubation incubation NN cord-276616-odmnvv7m 283 39 period period NN cord-276616-odmnvv7m 283 40 . . . cord-276616-odmnvv7m 284 1 They -PRON- PRP cord-276616-odmnvv7m 284 2 also also RB cord-276616-odmnvv7m 284 3 recorded record VBD cord-276616-odmnvv7m 284 4 altered altered JJ cord-276616-odmnvv7m 284 5 responses response NNS cord-276616-odmnvv7m 284 6 of of IN cord-276616-odmnvv7m 284 7 spleen spleen NN cord-276616-odmnvv7m 284 8 cells cell NNS cord-276616-odmnvv7m 284 9 to to IN cord-276616-odmnvv7m 284 10 mitogens mitogens NNP cord-276616-odmnvv7m 284 11 . . . cord-276616-odmnvv7m 285 1 As as IN cord-276616-odmnvv7m 285 2 in in IN cord-276616-odmnvv7m 285 3 other other JJ cord-276616-odmnvv7m 285 4 studies study NNS cord-276616-odmnvv7m 285 5 with with IN cord-276616-odmnvv7m 285 6 laboratory laboratory NN cord-276616-odmnvv7m 285 7 animals animal NNS cord-276616-odmnvv7m 285 8 , , , cord-276616-odmnvv7m 285 9 they -PRON- PRP cord-276616-odmnvv7m 285 10 could could MD cord-276616-odmnvv7m 285 11 not not RB cord-276616-odmnvv7m 285 12 entirely entirely RB cord-276616-odmnvv7m 285 13 rule rule VB cord-276616-odmnvv7m 285 14 out out RP cord-276616-odmnvv7m 285 15 the the DT cord-276616-odmnvv7m 285 16 possibility possibility NN cord-276616-odmnvv7m 285 17 that that IN cord-276616-odmnvv7m 285 18 a a DT cord-276616-odmnvv7m 285 19 passenger passenger NN cord-276616-odmnvv7m 285 20 virus virus NN cord-276616-odmnvv7m 285 21 or or CC cord-276616-odmnvv7m 285 22 microorganism microorganism NN cord-276616-odmnvv7m 285 23 was be VBD cord-276616-odmnvv7m 285 24 responsible responsible JJ cord-276616-odmnvv7m 285 25 for for IN cord-276616-odmnvv7m 285 26 these these DT cord-276616-odmnvv7m 285 27 changes change NNS cord-276616-odmnvv7m 285 28 . . . cord-276616-odmnvv7m 286 1 This this DT cord-276616-odmnvv7m 286 2 possibility possibility NN cord-276616-odmnvv7m 286 3 of of IN cord-276616-odmnvv7m 286 4 the the DT cord-276616-odmnvv7m 286 5 presence presence NN cord-276616-odmnvv7m 286 6 of of IN cord-276616-odmnvv7m 286 7 passenger passenger NN cord-276616-odmnvv7m 286 8 viruses virus NNS cord-276616-odmnvv7m 286 9 and and CC cord-276616-odmnvv7m 286 10 microorganisms microorganism NNS cord-276616-odmnvv7m 286 11 is be VBZ cord-276616-odmnvv7m 286 12 a a DT cord-276616-odmnvv7m 286 13 constant constant JJ cord-276616-odmnvv7m 286 14 obstacle obstacle NN cord-276616-odmnvv7m 286 15 to to IN cord-276616-odmnvv7m 286 16 understanding understand VBG cord-276616-odmnvv7m 286 17 the the DT cord-276616-odmnvv7m 286 18 results result NNS cord-276616-odmnvv7m 286 19 of of IN cord-276616-odmnvv7m 286 20 agent agent NN cord-276616-odmnvv7m 286 21 transmission transmission NN cord-276616-odmnvv7m 286 22 experiments experiment NNS cord-276616-odmnvv7m 286 23 in in IN cord-276616-odmnvv7m 286 24 laboratory laboratory NN cord-276616-odmnvv7m 286 25 animals animal NNS cord-276616-odmnvv7m 286 26 . . . cord-276616-odmnvv7m 287 1 Is be VBZ cord-276616-odmnvv7m 287 2 Spiroplasma Spiroplasma NNP cord-276616-odmnvv7m 287 3 mirum mirum NNP cord-276616-odmnvv7m 287 4 , , , cord-276616-odmnvv7m 287 5 proposed propose VBN cord-276616-odmnvv7m 287 6 as as IN cord-276616-odmnvv7m 287 7 a a DT cord-276616-odmnvv7m 287 8 possible possible JJ cord-276616-odmnvv7m 287 9 cause cause NN cord-276616-odmnvv7m 287 10 of of IN cord-276616-odmnvv7m 287 11 scrapie scrapie NN cord-276616-odmnvv7m 287 12 , , , cord-276616-odmnvv7m 287 13 merely merely RB cord-276616-odmnvv7m 287 14 a a DT cord-276616-odmnvv7m 287 15 passenger passenger NN cord-276616-odmnvv7m 287 16 responding respond VBG cord-276616-odmnvv7m 287 17 to to IN cord-276616-odmnvv7m 287 18 a a DT cord-276616-odmnvv7m 287 19 suppressed suppress VBN cord-276616-odmnvv7m 287 20 immune immune JJ cord-276616-odmnvv7m 287 21 state state NN cord-276616-odmnvv7m 287 22 in in IN cord-276616-odmnvv7m 287 23 the the DT cord-276616-odmnvv7m 287 24 same same JJ cord-276616-odmnvv7m 287 25 way way NN cord-276616-odmnvv7m 287 26 as as IN cord-276616-odmnvv7m 287 27 Pneumocystis Pneumocystis NNP cord-276616-odmnvv7m 287 28 carini carini NNP cord-276616-odmnvv7m 287 29 in in IN cord-276616-odmnvv7m 287 30 patients patient NNS cord-276616-odmnvv7m 287 31 with with IN cord-276616-odmnvv7m 287 32 AIDS AIDS NNP cord-276616-odmnvv7m 287 33 ( ( -LRB- cord-276616-odmnvv7m 287 34 Redfield Redfield NNP cord-276616-odmnvv7m 287 35 and and CC cord-276616-odmnvv7m 287 36 Burke Burke NNP cord-276616-odmnvv7m 287 37 , , , cord-276616-odmnvv7m 287 38 1988 1988 CD cord-276616-odmnvv7m 287 39 ) ) -RRB- cord-276616-odmnvv7m 287 40 ? ? . cord-276616-odmnvv7m 288 1 Any any DT cord-276616-odmnvv7m 288 2 passenger passenger NN cord-276616-odmnvv7m 288 3 agents agent NNS cord-276616-odmnvv7m 288 4 involved involve VBN cord-276616-odmnvv7m 288 5 in in IN cord-276616-odmnvv7m 288 6 the the DT cord-276616-odmnvv7m 288 7 spongiform spongiform JJ cord-276616-odmnvv7m 288 8 encephalopathies encephalopathy NNS cord-276616-odmnvv7m 288 9 might may MD cord-276616-odmnvv7m 288 10 well well RB cord-276616-odmnvv7m 288 11 vary vary VB cord-276616-odmnvv7m 288 12 according accord VBG cord-276616-odmnvv7m 288 13 to to IN cord-276616-odmnvv7m 288 14 the the DT cord-276616-odmnvv7m 288 15 host host NN cord-276616-odmnvv7m 288 16 species specie NNS cord-276616-odmnvv7m 288 17 . . . cord-276616-odmnvv7m 289 1 Because because IN cord-276616-odmnvv7m 289 2 of of IN cord-276616-odmnvv7m 289 3 the the DT cord-276616-odmnvv7m 289 4 widespread widespread JJ cord-276616-odmnvv7m 289 5 consumption consumption NN cord-276616-odmnvv7m 289 6 of of IN cord-276616-odmnvv7m 289 7 products product NNS cord-276616-odmnvv7m 289 8 obtained obtain VBN cord-276616-odmnvv7m 289 9 from from IN cord-276616-odmnvv7m 289 10 cattle cattle NNS cord-276616-odmnvv7m 289 11 by by IN cord-276616-odmnvv7m 289 12 most most JJS cord-276616-odmnvv7m 289 13 of of IN cord-276616-odmnvv7m 289 14 the the DT cord-276616-odmnvv7m 289 15 human human JJ cord-276616-odmnvv7m 289 16 population population NN cord-276616-odmnvv7m 289 17 , , , cord-276616-odmnvv7m 289 18 the the DT cord-276616-odmnvv7m 289 19 recent recent JJ cord-276616-odmnvv7m 289 20 outbreak outbreak NN cord-276616-odmnvv7m 289 21 of of IN cord-276616-odmnvv7m 289 22 BSE BSE NNP cord-276616-odmnvv7m 289 23 has have VBZ cord-276616-odmnvv7m 289 24 caused cause VBN cord-276616-odmnvv7m 289 25 great great JJ cord-276616-odmnvv7m 289 26 alarm alarm NN cord-276616-odmnvv7m 289 27 and and CC cord-276616-odmnvv7m 289 28 has have VBZ cord-276616-odmnvv7m 289 29 been be VBN cord-276616-odmnvv7m 289 30 the the DT cord-276616-odmnvv7m 289 31 subject subject NN cord-276616-odmnvv7m 289 32 of of IN cord-276616-odmnvv7m 289 33 a a DT cord-276616-odmnvv7m 289 34 considerable considerable JJ cord-276616-odmnvv7m 289 35 correspondence correspondence NN cord-276616-odmnvv7m 289 36 in in IN cord-276616-odmnvv7m 289 37 the the DT cord-276616-odmnvv7m 289 38 British british JJ cord-276616-odmnvv7m 289 39 medical medical JJ cord-276616-odmnvv7m 289 40 press press NN cord-276616-odmnvv7m 289 41 . . . cord-276616-odmnvv7m 290 1 It -PRON- PRP cord-276616-odmnvv7m 290 2 is be VBZ cord-276616-odmnvv7m 290 3 not not RB cord-276616-odmnvv7m 290 4 known know VBN cord-276616-odmnvv7m 290 5 whether whether IN cord-276616-odmnvv7m 290 6 cattle cattle NNS cord-276616-odmnvv7m 290 7 are be VBP cord-276616-odmnvv7m 290 8 the the DT cord-276616-odmnvv7m 290 9 final final JJ cord-276616-odmnvv7m 290 10 hosts host NNS cord-276616-odmnvv7m 290 11 , , , cord-276616-odmnvv7m 290 12 nor nor CC cord-276616-odmnvv7m 290 13 whether whether IN cord-276616-odmnvv7m 290 14 the the DT cord-276616-odmnvv7m 290 15 infection infection NN cord-276616-odmnvv7m 290 16 can can MD cord-276616-odmnvv7m 290 17 spread spread VB cord-276616-odmnvv7m 290 18 to to IN cord-276616-odmnvv7m 290 19 humans human NNS cord-276616-odmnvv7m 290 20 by by IN cord-276616-odmnvv7m 290 21 the the DT cord-276616-odmnvv7m 290 22 consumption consumption NN cord-276616-odmnvv7m 290 23 of of IN cord-276616-odmnvv7m 290 24 beef beef NN cord-276616-odmnvv7m 290 25 , , , cord-276616-odmnvv7m 290 26 milk milk NN cord-276616-odmnvv7m 290 27 or or CC cord-276616-odmnvv7m 290 28 products product NNS cord-276616-odmnvv7m 290 29 , , , cord-276616-odmnvv7m 290 30 such such JJ cord-276616-odmnvv7m 290 31 as as IN cord-276616-odmnvv7m 290 32 bovine bovine JJ cord-276616-odmnvv7m 290 33 albumin albumin NN cord-276616-odmnvv7m 290 34 used use VBN cord-276616-odmnvv7m 290 35 in in IN cord-276616-odmnvv7m 290 36 various various JJ cord-276616-odmnvv7m 290 37 forms form NNS cord-276616-odmnvv7m 290 38 of of IN cord-276616-odmnvv7m 290 39 therapy therapy NN cord-276616-odmnvv7m 290 40 9 9 CD cord-276616-odmnvv7m 290 41 . . . cord-276616-odmnvv7m 291 1 With with IN cord-276616-odmnvv7m 291 2 the the DT cord-276616-odmnvv7m 291 3 ability ability NN cord-276616-odmnvv7m 291 4 for for IN cord-276616-odmnvv7m 291 5 agents agent NNS cord-276616-odmnvv7m 291 6 causing cause VBG cord-276616-odmnvv7m 291 7 the the DT cord-276616-odmnvv7m 291 8 spongiform spongiform JJ cord-276616-odmnvv7m 291 9 encephalopathies encephalopathy NNS cord-276616-odmnvv7m 291 10 to to TO cord-276616-odmnvv7m 291 11 cross cross VB cord-276616-odmnvv7m 291 12 specimen specimen JJ cord-276616-odmnvv7m 291 13 boundaries boundary NNS cord-276616-odmnvv7m 291 14 , , , cord-276616-odmnvv7m 291 15 the the DT cord-276616-odmnvv7m 291 16 fear fear NN cord-276616-odmnvv7m 291 17 that that IN cord-276616-odmnvv7m 291 18 people people NNS cord-276616-odmnvv7m 291 19 might may MD cord-276616-odmnvv7m 291 20 acquire acquire VB cord-276616-odmnvv7m 291 21 human human JJ cord-276616-odmnvv7m 291 22 forms form NNS cord-276616-odmnvv7m 291 23 of of IN cord-276616-odmnvv7m 291 24 these these DT cord-276616-odmnvv7m 291 25 diseases disease NNS cord-276616-odmnvv7m 291 26 from from IN cord-276616-odmnvv7m 291 27 cattle cattle NNS cord-276616-odmnvv7m 291 28 has have VBZ cord-276616-odmnvv7m 291 29 to to TO cord-276616-odmnvv7m 291 30 be be VB cord-276616-odmnvv7m 291 31 very very RB cord-276616-odmnvv7m 291 32 real real JJ cord-276616-odmnvv7m 291 33 . . . cord-276616-odmnvv7m 292 1 It -PRON- PRP cord-276616-odmnvv7m 292 2 might may MD cord-276616-odmnvv7m 292 3 be be VB cord-276616-odmnvv7m 292 4 assumed assume VBN cord-276616-odmnvv7m 292 5 , , , cord-276616-odmnvv7m 292 6 for for IN cord-276616-odmnvv7m 292 7 instance instance NN cord-276616-odmnvv7m 292 8 , , , cord-276616-odmnvv7m 292 9 that that IN cord-276616-odmnvv7m 292 10 , , , cord-276616-odmnvv7m 292 11 as as IN cord-276616-odmnvv7m 292 12 a a DT cord-276616-odmnvv7m 292 13 result result NN cord-276616-odmnvv7m 292 14 of of IN cord-276616-odmnvv7m 292 15 the the DT cord-276616-odmnvv7m 292 16 epidemic epidemic NN cord-276616-odmnvv7m 292 17 of of IN cord-276616-odmnvv7m 292 18 BSE BSE NNP cord-276616-odmnvv7m 292 19 through through IN cord-276616-odmnvv7m 292 20 which which WDT cord-276616-odmnvv7m 292 21 British british JJ cord-276616-odmnvv7m 292 22 cattle cattle NNS cord-276616-odmnvv7m 292 23 have have VBP cord-276616-odmnvv7m 292 24 passed pass VBN cord-276616-odmnvv7m 292 25 , , , cord-276616-odmnvv7m 292 26 slaughterhouse slaughterhouse NN cord-276616-odmnvv7m 292 27 workers worker NNS cord-276616-odmnvv7m 292 28 will will MD cord-276616-odmnvv7m 292 29 have have VB cord-276616-odmnvv7m 292 30 inadvertently inadvertently RB cord-276616-odmnvv7m 292 31 come come VBN cord-276616-odmnvv7m 292 32 into into IN cord-276616-odmnvv7m 292 33 contact contact NN cord-276616-odmnvv7m 292 34 with with IN cord-276616-odmnvv7m 292 35 preclinical preclinical JJ cord-276616-odmnvv7m 292 36 cases case NNS cord-276616-odmnvv7m 292 37 ( ( -LRB- cord-276616-odmnvv7m 292 38 Howard Howard NNP cord-276616-odmnvv7m 292 39 and and CC cord-276616-odmnvv7m 292 40 Castle Castle NNP cord-276616-odmnvv7m 292 41 , , , cord-276616-odmnvv7m 292 42 1990 1990 CD cord-276616-odmnvv7m 292 43 ; ; : cord-276616-odmnvv7m 292 44 DeaUer DeaUer NNP cord-276616-odmnvv7m 292 45 and and CC cord-276616-odmnvv7m 292 46 Lacey Lacey NNP cord-276616-odmnvv7m 292 47 , , , cord-276616-odmnvv7m 292 48 1991 1991 CD cord-276616-odmnvv7m 292 49 ; ; : cord-276616-odmnvv7m 292 50 Coyle Coyle NNP cord-276616-odmnvv7m 292 51 and and CC cord-276616-odmnvv7m 292 52 Harvey Harvey NNP cord-276616-odmnvv7m 292 53 , , , cord-276616-odmnvv7m 292 54 1992 1992 CD cord-276616-odmnvv7m 292 55 ) ) -RRB- cord-276616-odmnvv7m 292 56 . . . cord-276616-odmnvv7m 293 1 Scrimgeour Scrimgeour NNP cord-276616-odmnvv7m 293 2 and and CC cord-276616-odmnvv7m 293 3 Brown Brown NNP cord-276616-odmnvv7m 293 4 ( ( -LRB- cord-276616-odmnvv7m 293 5 1991 1991 CD cord-276616-odmnvv7m 293 6 ) ) -RRB- cord-276616-odmnvv7m 293 7 pointed point VBD cord-276616-odmnvv7m 293 8 out out RP cord-276616-odmnvv7m 293 9 that that IN cord-276616-odmnvv7m 293 10 the the DT cord-276616-odmnvv7m 293 11 most most RBS cord-276616-odmnvv7m 293 12 efficient efficient JJ cord-276616-odmnvv7m 293 13 means mean NNS cord-276616-odmnvv7m 293 14 for for IN cord-276616-odmnvv7m 293 15 transmission transmission NN cord-276616-odmnvv7m 293 16 of of IN cord-276616-odmnvv7m 293 17 scrapie scrapie NN cord-276616-odmnvv7m 293 18 , , , cord-276616-odmnvv7m 293 19 other other JJ cord-276616-odmnvv7m 293 20 than than IN cord-276616-odmnvv7m 293 21 the the DT cord-276616-odmnvv7m 293 22 parenteral parenteral JJ cord-276616-odmnvv7m 293 23 routes route NNS cord-276616-odmnvv7m 293 24 used use VBN cord-276616-odmnvv7m 293 25 experimentally experimentally RB cord-276616-odmnvv7m 293 26 , , , cord-276616-odmnvv7m 293 27 are be VBP cord-276616-odmnvv7m 293 28 via via IN cord-276616-odmnvv7m 293 29 the the DT cord-276616-odmnvv7m 293 30 conjunctival conjunctival NN cord-276616-odmnvv7m 293 31 and and CC cord-276616-odmnvv7m 293 32 nasal nasal NN cord-276616-odmnvv7m 293 33 mucosae mucosae JJ cord-276616-odmnvv7m 293 34 and and CC cord-276616-odmnvv7m 293 35 cutaneous cutaneous JJ cord-276616-odmnvv7m 293 36 abrasions abrasion NNS cord-276616-odmnvv7m 293 37 . . . cord-276616-odmnvv7m 294 1 They -PRON- PRP cord-276616-odmnvv7m 294 2 suggested suggest VBD cord-276616-odmnvv7m 294 3 that that IN cord-276616-odmnvv7m 294 4 slaughterhouse slaughterhouse NN cord-276616-odmnvv7m 294 5 workers worker NNS cord-276616-odmnvv7m 294 6 would would MD cord-276616-odmnvv7m 294 7 be be VB cord-276616-odmnvv7m 294 8 prone prone JJ cord-276616-odmnvv7m 294 9 to to IN cord-276616-odmnvv7m 294 10 this this DT cord-276616-odmnvv7m 294 11 type type NN cord-276616-odmnvv7m 294 12 of of IN cord-276616-odmnvv7m 294 13 contact contact NN cord-276616-odmnvv7m 294 14 with with IN cord-276616-odmnvv7m 294 15 microbial microbial JJ cord-276616-odmnvv7m 294 16 zoonoses zoonosis NNS cord-276616-odmnvv7m 294 17 . . . cord-276616-odmnvv7m 295 1 The the DT cord-276616-odmnvv7m 295 2 wearing wearing NN cord-276616-odmnvv7m 295 3 of of IN cord-276616-odmnvv7m 295 4 protective protective JJ cord-276616-odmnvv7m 295 5 clothing clothing NN cord-276616-odmnvv7m 295 6 by by IN cord-276616-odmnvv7m 295 7 these these DT cord-276616-odmnvv7m 295 8 individuals individual NNS cord-276616-odmnvv7m 295 9 when when WRB cord-276616-odmnvv7m 295 10 they -PRON- PRP cord-276616-odmnvv7m 295 11 are be VBP cord-276616-odmnvv7m 295 12 extracting extract VBG cord-276616-odmnvv7m 295 13 the the DT cord-276616-odmnvv7m 295 14 cranial cranial JJ cord-276616-odmnvv7m 295 15 contents content NNS cord-276616-odmnvv7m 295 16 from from IN cord-276616-odmnvv7m 295 17 cattle cattle NNS cord-276616-odmnvv7m 295 18 was be VBD cord-276616-odmnvv7m 295 19 also also RB cord-276616-odmnvv7m 295 20 advised advise VBN cord-276616-odmnvv7m 295 21 . . . cord-276616-odmnvv7m 296 1 However however RB cord-276616-odmnvv7m 296 2 , , , cord-276616-odmnvv7m 296 3 these these DT cord-276616-odmnvv7m 296 4 fears fear NNS cord-276616-odmnvv7m 296 5 of of IN cord-276616-odmnvv7m 296 6 the the DT cord-276616-odmnvv7m 296 7 human human JJ cord-276616-odmnvv7m 296 8 population population NN cord-276616-odmnvv7m 296 9 acquiring acquire VBG cord-276616-odmnvv7m 296 10 BSE BSE NNP cord-276616-odmnvv7m 296 11 should should MD cord-276616-odmnvv7m 296 12 be be VB cord-276616-odmnvv7m 296 13 tempered temper VBN cord-276616-odmnvv7m 296 14 by by IN cord-276616-odmnvv7m 296 15 realism realism NN cord-276616-odmnvv7m 296 16 ( ( -LRB- cord-276616-odmnvv7m 296 17 Collee Collee NNP cord-276616-odmnvv7m 296 18 , , , cord-276616-odmnvv7m 296 19 1991 1991 CD cord-276616-odmnvv7m 296 20 ) ) -RRB- cord-276616-odmnvv7m 296 21 . . . cord-276616-odmnvv7m 297 1 CJD CJD NNP cord-276616-odmnvv7m 297 2 often often RB cord-276616-odmnvv7m 297 3 occurs occur VBZ cord-276616-odmnvv7m 297 4 in in IN cord-276616-odmnvv7m 297 5 clusters cluster NNS cord-276616-odmnvv7m 297 6 with with IN cord-276616-odmnvv7m 297 7 a a DT cord-276616-odmnvv7m 297 8 history history NN cord-276616-odmnvv7m 297 9 of of IN cord-276616-odmnvv7m 297 10 familial familial JJ cord-276616-odmnvv7m 297 11 relationships relationship NNS cord-276616-odmnvv7m 297 12 , , , cord-276616-odmnvv7m 297 13 and and CC cord-276616-odmnvv7m 297 14 these these DT cord-276616-odmnvv7m 297 15 seem seem VBP cord-276616-odmnvv7m 297 16 to to TO cord-276616-odmnvv7m 297 17 have have VB cord-276616-odmnvv7m 297 18 more more JJR cord-276616-odmnvv7m 297 19 relevance relevance NN cord-276616-odmnvv7m 297 20 to to IN cord-276616-odmnvv7m 297 21 the the DT cord-276616-odmnvv7m 297 22 incidence incidence NN cord-276616-odmnvv7m 297 23 of of IN cord-276616-odmnvv7m 297 24 the the DT cord-276616-odmnvv7m 297 25 disease disease NN cord-276616-odmnvv7m 297 26 than than IN cord-276616-odmnvv7m 297 27 do do VB cord-276616-odmnvv7m 297 28 eating eating NN cord-276616-odmnvv7m 297 29 habits habit NNS cord-276616-odmnvv7m 297 30 ( ( -LRB- cord-276616-odmnvv7m 297 31 Taylor Taylor NNP cord-276616-odmnvv7m 297 32 , , , cord-276616-odmnvv7m 297 33 1989 1989 CD cord-276616-odmnvv7m 297 34 ) ) -RRB- cord-276616-odmnvv7m 297 35 . . . cord-276616-odmnvv7m 298 1 If if IN cord-276616-odmnvv7m 298 2 BSE BSE NNP cord-276616-odmnvv7m 298 3 presents present VBZ cord-276616-odmnvv7m 298 4 a a DT cord-276616-odmnvv7m 298 5 hazard hazard NN cord-276616-odmnvv7m 298 6 to to IN cord-276616-odmnvv7m 298 7 the the DT cord-276616-odmnvv7m 298 8 human human JJ cord-276616-odmnvv7m 298 9 population population NN cord-276616-odmnvv7m 298 10 , , , cord-276616-odmnvv7m 298 11 especially especially RB cord-276616-odmnvv7m 298 12 to to IN cord-276616-odmnvv7m 298 13 veterinarians veterinarian NNS cord-276616-odmnvv7m 298 14 or or CC cord-276616-odmnvv7m 298 15 to to IN cord-276616-odmnvv7m 298 16 slaughterhouse slaughterhouse NN cord-276616-odmnvv7m 298 17 personnel personnel NNS cord-276616-odmnvv7m 298 18 , , , cord-276616-odmnvv7m 298 19 a a DT cord-276616-odmnvv7m 298 20 statistical statistical JJ cord-276616-odmnvv7m 298 21 study study NN cord-276616-odmnvv7m 298 22 of of IN cord-276616-odmnvv7m 298 23 the the DT cord-276616-odmnvv7m 298 24 occurrence occurrence NN cord-276616-odmnvv7m 298 25 of of IN cord-276616-odmnvv7m 298 26 spongiform spongiform JJ cord-276616-odmnvv7m 298 27 encephalopathy encephalopathy NN cord-276616-odmnvv7m 298 28 over over IN cord-276616-odmnvv7m 298 29 the the DT cord-276616-odmnvv7m 298 30 next next JJ cord-276616-odmnvv7m 298 31 several several JJ cord-276616-odmnvv7m 298 32 years year NNS cord-276616-odmnvv7m 298 33 should should MD cord-276616-odmnvv7m 298 34 show show VB cord-276616-odmnvv7m 298 35 whether whether IN cord-276616-odmnvv7m 298 36 the the DT cord-276616-odmnvv7m 298 37 incidence incidence NN cord-276616-odmnvv7m 298 38 of of IN cord-276616-odmnvv7m 298 39 CJD CJD NNP cord-276616-odmnvv7m 298 40 has have VBZ cord-276616-odmnvv7m 298 41 increased increase VBN cord-276616-odmnvv7m 298 42 as as IN cord-276616-odmnvv7m 298 43 a a DT cord-276616-odmnvv7m 298 44 result result NN cord-276616-odmnvv7m 298 45 of of IN cord-276616-odmnvv7m 298 46 the the DT cord-276616-odmnvv7m 298 47 intimate intimate JJ cord-276616-odmnvv7m 298 48 exposure exposure NN cord-276616-odmnvv7m 298 49 to to IN cord-276616-odmnvv7m 298 50 cattle cattle NNS cord-276616-odmnvv7m 298 51 . . . cord-276616-odmnvv7m 299 1 The the DT cord-276616-odmnvv7m 299 2 potential potential JJ cord-276616-odmnvv7m 299 3 risks risk NNS cord-276616-odmnvv7m 299 4 to to IN cord-276616-odmnvv7m 299 5 which which WDT cord-276616-odmnvv7m 299 6 the the DT cord-276616-odmnvv7m 299 7 British british JJ cord-276616-odmnvv7m 299 8 meat meat NN cord-276616-odmnvv7m 299 9 - - HYPH cord-276616-odmnvv7m 299 10 eating eat VBG cord-276616-odmnvv7m 299 11 population population NN cord-276616-odmnvv7m 299 12 has have VBZ cord-276616-odmnvv7m 299 13 been be VBN cord-276616-odmnvv7m 299 14 exposed expose VBN cord-276616-odmnvv7m 299 15 have have VBP cord-276616-odmnvv7m 299 16 led lead VBN cord-276616-odmnvv7m 299 17 to to IN cord-276616-odmnvv7m 299 18 funding funding NN cord-276616-odmnvv7m 299 19 of of IN cord-276616-odmnvv7m 299 20 the the DT cord-276616-odmnvv7m 299 21 surveillance surveillance NN cord-276616-odmnvv7m 299 22 of of IN cord-276616-odmnvv7m 299 23 cases case NNS cord-276616-odmnvv7m 299 24 of of IN cord-276616-odmnvv7m 299 25 CJD CJD NNP cord-276616-odmnvv7m 299 26 that that WDT cord-276616-odmnvv7m 299 27 arise arise VBP cord-276616-odmnvv7m 299 28 in in IN cord-276616-odmnvv7m 299 29 the the DT cord-276616-odmnvv7m 299 30 United United NNP cord-276616-odmnvv7m 299 31 Kingdom Kingdom NNP cord-276616-odmnvv7m 299 32 , , , cord-276616-odmnvv7m 299 33 with with IN cord-276616-odmnvv7m 299 34 particular particular JJ cord-276616-odmnvv7m 299 35 reference reference NN cord-276616-odmnvv7m 299 36 to to IN cord-276616-odmnvv7m 299 37 the the DT cord-276616-odmnvv7m 299 38 dietary dietary JJ cord-276616-odmnvv7m 299 39 and and CC cord-276616-odmnvv7m 299 40 occupational occupational JJ cord-276616-odmnvv7m 299 41 history history NN cord-276616-odmnvv7m 299 42 and and CC cord-276616-odmnvv7m 299 43 other other JJ cord-276616-odmnvv7m 299 44 possible possible JJ cord-276616-odmnvv7m 299 45 risks risk NNS cord-276616-odmnvv7m 299 46 . . . cord-276616-odmnvv7m 300 1 However however RB cord-276616-odmnvv7m 300 2 , , , cord-276616-odmnvv7m 300 3 Fear Fear NNP cord-276616-odmnvv7m 300 4 and and CC cord-276616-odmnvv7m 300 5 Devakumar Devakumar NNP cord-276616-odmnvv7m 300 6 ( ( -LRB- cord-276616-odmnvv7m 300 7 1990 1990 CD cord-276616-odmnvv7m 300 8 ) ) -RRB- cord-276616-odmnvv7m 300 9 have have VBP cord-276616-odmnvv7m 300 10 questioned question VBN cord-276616-odmnvv7m 300 11 the the DT cord-276616-odmnvv7m 300 12 accuracy accuracy NN cord-276616-odmnvv7m 300 13 of of IN cord-276616-odmnvv7m 300 14 such such PDT cord-276616-odmnvv7m 300 15 an an DT cord-276616-odmnvv7m 300 16 ongoing ongoing JJ cord-276616-odmnvv7m 300 17 survey survey NN cord-276616-odmnvv7m 300 18 , , , cord-276616-odmnvv7m 300 19 given give VBN cord-276616-odmnvv7m 300 20 the the DT cord-276616-odmnvv7m 300 21 variety variety NN cord-276616-odmnvv7m 300 22 of of IN cord-276616-odmnvv7m 300 23 symptoms symptom NNS cord-276616-odmnvv7m 300 24 exhibited exhibit VBN cord-276616-odmnvv7m 300 25 by by IN cord-276616-odmnvv7m 300 26 patients patient NNS cord-276616-odmnvv7m 300 27 with with IN cord-276616-odmnvv7m 300 28 CJD CJD NNP cord-276616-odmnvv7m 300 29 . . . cord-276616-odmnvv7m 301 1 A a DT cord-276616-odmnvv7m 301 2 major major JJ cord-276616-odmnvv7m 301 3 problem problem NN cord-276616-odmnvv7m 301 4 with with IN cord-276616-odmnvv7m 301 5 experimental experimental JJ cord-276616-odmnvv7m 301 6 work work NN cord-276616-odmnvv7m 301 7 on on IN cord-276616-odmnvv7m 301 8 the the DT cord-276616-odmnvv7m 301 9 encephalopathies encephalopathy NNS cord-276616-odmnvv7m 301 10 is be VBZ cord-276616-odmnvv7m 301 11 the the DT cord-276616-odmnvv7m 301 12 resistance resistance NN cord-276616-odmnvv7m 301 13 of of IN cord-276616-odmnvv7m 301 14 the the DT cord-276616-odmnvv7m 301 15 agent agent NN cord-276616-odmnvv7m 301 16 . . . cord-276616-odmnvv7m 302 1 In in IN cord-276616-odmnvv7m 302 2 performing perform VBG cord-276616-odmnvv7m 302 3 experiments experiment NNS cord-276616-odmnvv7m 302 4 on on IN cord-276616-odmnvv7m 302 5 scrapie scrapie NN cord-276616-odmnvv7m 302 6 , , , cord-276616-odmnvv7m 302 7 etc etc FW cord-276616-odmnvv7m 302 8 . . FW cord-276616-odmnvv7m 302 9 , , , cord-276616-odmnvv7m 302 10 great great JJ cord-276616-odmnvv7m 302 11 care care NN cord-276616-odmnvv7m 302 12 has have VBZ cord-276616-odmnvv7m 302 13 to to TO cord-276616-odmnvv7m 302 14 be be VB cord-276616-odmnvv7m 302 15 taken take VBN cord-276616-odmnvv7m 302 16 to to TO cord-276616-odmnvv7m 302 17 avoid avoid VB cord-276616-odmnvv7m 302 18 using use VBG cord-276616-odmnvv7m 302 19 contaminated contaminate VBN cord-276616-odmnvv7m 302 20 laboratory laboratory NN cord-276616-odmnvv7m 302 21 equipment equipment NN cord-276616-odmnvv7m 302 22 . . . cord-276616-odmnvv7m 303 1 Illustrations illustration NNS cord-276616-odmnvv7m 303 2 of of IN cord-276616-odmnvv7m 303 3 the the DT cord-276616-odmnvv7m 303 4 care care NN cord-276616-odmnvv7m 303 5 that that WDT cord-276616-odmnvv7m 303 6 has have VBZ cord-276616-odmnvv7m 303 7 to to TO cord-276616-odmnvv7m 303 8 be be VB cord-276616-odmnvv7m 303 9 taken take VBN cord-276616-odmnvv7m 303 10 are be VBP cord-276616-odmnvv7m 303 11 the the DT cord-276616-odmnvv7m 303 12 technical technical JJ cord-276616-odmnvv7m 303 13 details detail NNS cord-276616-odmnvv7m 303 14 given give VBN cord-276616-odmnvv7m 303 15 in in IN cord-276616-odmnvv7m 303 16 papers paper NNS cord-276616-odmnvv7m 303 17 on on IN cord-276616-odmnvv7m 303 18 the the DT cord-276616-odmnvv7m 303 19 oral oral JJ cord-276616-odmnvv7m 303 20 transmission transmission NN cord-276616-odmnvv7m 303 21 of of IN cord-276616-odmnvv7m 303 22 BSE BSE NNP cord-276616-odmnvv7m 303 23 to to IN cord-276616-odmnvv7m 303 24 mice mouse NNS cord-276616-odmnvv7m 303 25 ( ( -LRB- cord-276616-odmnvv7m 303 26 Barlow Barlow NNP cord-276616-odmnvv7m 303 27 and and CC cord-276616-odmnvv7m 303 28 Middleton Middleton NNP cord-276616-odmnvv7m 303 29 , , , cord-276616-odmnvv7m 303 30 1991 1991 CD cord-276616-odmnvv7m 303 31 ) ) -RRB- cord-276616-odmnvv7m 303 32 and and CC cord-276616-odmnvv7m 303 33 in in IN cord-276616-odmnvv7m 303 34 the the DT cord-276616-odmnvv7m 303 35 transmission transmission NN cord-276616-odmnvv7m 303 36 studies study NNS cord-276616-odmnvv7m 303 37 with with IN cord-276616-odmnvv7m 303 38 Alzheimer Alzheimer NNP cord-276616-odmnvv7m 303 39 's 's POS cord-276616-odmnvv7m 303 40 disease disease NN cord-276616-odmnvv7m 303 41 ( ( -LRB- cord-276616-odmnvv7m 303 42 Manuelidis Manuelidis NNP cord-276616-odmnvv7m 303 43 and and CC cord-276616-odmnvv7m 303 44 Manuelidis Manuelidis NNP cord-276616-odmnvv7m 303 45 , , , cord-276616-odmnvv7m 303 46 1991 1991 CD cord-276616-odmnvv7m 303 47 ) ) -RRB- cord-276616-odmnvv7m 303 48 . . . cord-276616-odmnvv7m 304 1 The the DT cord-276616-odmnvv7m 304 2 innate innate JJ cord-276616-odmnvv7m 304 3 resistance resistance NN cord-276616-odmnvv7m 304 4 of of IN cord-276616-odmnvv7m 304 5 a a DT cord-276616-odmnvv7m 304 6 proportion proportion NN cord-276616-odmnvv7m 304 7 of of IN cord-276616-odmnvv7m 304 8 the the DT cord-276616-odmnvv7m 304 9 population population NN cord-276616-odmnvv7m 304 10 to to IN cord-276616-odmnvv7m 304 11 experimental experimental JJ cord-276616-odmnvv7m 304 12 transmission transmission NN cord-276616-odmnvv7m 304 13 of of IN cord-276616-odmnvv7m 304 14 the the DT cord-276616-odmnvv7m 304 15 spongiform spongiform JJ cord-276616-odmnvv7m 304 16 encephalopathies encephalopathy NNS cord-276616-odmnvv7m 304 17 is be VBZ cord-276616-odmnvv7m 304 18 seen see VBN cord-276616-odmnvv7m 304 19 as as IN cord-276616-odmnvv7m 304 20 the the DT cord-276616-odmnvv7m 304 21 result result NN cord-276616-odmnvv7m 304 22 of of IN cord-276616-odmnvv7m 304 23 genetic genetic JJ cord-276616-odmnvv7m 304 24 influences influence NNS cord-276616-odmnvv7m 304 25 . . . cord-276616-odmnvv7m 305 1 Some some DT cord-276616-odmnvv7m 305 2 animals animal NNS cord-276616-odmnvv7m 305 3 within within IN cord-276616-odmnvv7m 305 4 a a DT cord-276616-odmnvv7m 305 5 species species NN cord-276616-odmnvv7m 305 6 will will MD cord-276616-odmnvv7m 305 7 prove prove VB cord-276616-odmnvv7m 305 8 resistant resistant JJ cord-276616-odmnvv7m 305 9 to to IN cord-276616-odmnvv7m 305 10 experimental experimental JJ cord-276616-odmnvv7m 305 11 infection infection NN cord-276616-odmnvv7m 305 12 following follow VBG cord-276616-odmnvv7m 305 13 infection infection NN cord-276616-odmnvv7m 305 14 . . . cord-276616-odmnvv7m 306 1 However however RB cord-276616-odmnvv7m 306 2 , , , cord-276616-odmnvv7m 306 3 the the DT cord-276616-odmnvv7m 306 4 degree degree NN cord-276616-odmnvv7m 306 5 of of IN cord-276616-odmnvv7m 306 6 resistance resistance NN cord-276616-odmnvv7m 306 7 will will MD cord-276616-odmnvv7m 306 8 vary vary VB cord-276616-odmnvv7m 306 9 according accord VBG cord-276616-odmnvv7m 306 10 to to IN cord-276616-odmnvv7m 306 11 the the DT cord-276616-odmnvv7m 306 12 route route NN cord-276616-odmnvv7m 306 13 of of IN cord-276616-odmnvv7m 306 14 infection infection NN cord-276616-odmnvv7m 306 15 . . . cord-276616-odmnvv7m 307 1 In in IN cord-276616-odmnvv7m 307 2 most most JJS cord-276616-odmnvv7m 307 3 species specie NNS cord-276616-odmnvv7m 307 4 , , , cord-276616-odmnvv7m 307 5 the the DT cord-276616-odmnvv7m 307 6 natural natural JJ cord-276616-odmnvv7m 307 7 route route NN cord-276616-odmnvv7m 307 8 of of IN cord-276616-odmnvv7m 307 9 infection infection NN cord-276616-odmnvv7m 307 10 appears appear VBZ cord-276616-odmnvv7m 307 11 to to TO cord-276616-odmnvv7m 307 12 be be VB cord-276616-odmnvv7m 307 13 the the DT cord-276616-odmnvv7m 307 14 oral oral JJ cord-276616-odmnvv7m 307 15 route route NN cord-276616-odmnvv7m 307 16 and and CC cord-276616-odmnvv7m 307 17 innate innate JJ cord-276616-odmnvv7m 307 18 resistance resistance NN cord-276616-odmnvv7m 307 19 is be VBZ cord-276616-odmnvv7m 307 20 then then RB cord-276616-odmnvv7m 307 21 likely likely JJ cord-276616-odmnvv7m 307 22 to to TO cord-276616-odmnvv7m 307 23 be be VB cord-276616-odmnvv7m 307 24 more more RBR cord-276616-odmnvv7m 307 25 important important JJ cord-276616-odmnvv7m 307 26 than than IN cord-276616-odmnvv7m 307 27 when when WRB cord-276616-odmnvv7m 307 28 animals animal NNS cord-276616-odmnvv7m 307 29 are be VBP cord-276616-odmnvv7m 307 30 infected infect VBN cord-276616-odmnvv7m 307 31 intracerebrally intracerebrally RB cord-276616-odmnvv7m 307 32 . . . cord-276616-odmnvv7m 308 1 Offspring offspring NN cord-276616-odmnvv7m 308 2 from from IN cord-276616-odmnvv7m 308 3 infected infected JJ cord-276616-odmnvv7m 308 4 ewes ewe NNS cord-276616-odmnvv7m 308 5 are be VBP cord-276616-odmnvv7m 308 6 prone prone JJ cord-276616-odmnvv7m 308 7 to to TO cord-276616-odmnvv7m 308 8 develop develop VB cord-276616-odmnvv7m 308 9 scrapie scrapie NN cord-276616-odmnvv7m 308 10 . . . cord-276616-odmnvv7m 309 1 This this DT cord-276616-odmnvv7m 309 2 may may MD cord-276616-odmnvv7m 309 3 be be VB cord-276616-odmnvv7m 309 4 evidence evidence NN cord-276616-odmnvv7m 309 5 of of IN cord-276616-odmnvv7m 309 6 a a DT cord-276616-odmnvv7m 309 7 familial familial JJ cord-276616-odmnvv7m 309 8 trait trait NN cord-276616-odmnvv7m 309 9 and and CC cord-276616-odmnvv7m 309 10 the the DT cord-276616-odmnvv7m 309 11 practice practice NN cord-276616-odmnvv7m 309 12 has have VBZ cord-276616-odmnvv7m 309 13 been be VBN cord-276616-odmnvv7m 309 14 to to TO cord-276616-odmnvv7m 309 15 remove remove VB cord-276616-odmnvv7m 309 16 affected affected JJ cord-276616-odmnvv7m 309 17 family family NN cord-276616-odmnvv7m 309 18 lines line NNS cord-276616-odmnvv7m 309 19 in in IN cord-276616-odmnvv7m 309 20 attempts attempt NNS cord-276616-odmnvv7m 309 21 to to TO cord-276616-odmnvv7m 309 22 control control VB cord-276616-odmnvv7m 309 23 the the DT cord-276616-odmnvv7m 309 24 disease disease NN cord-276616-odmnvv7m 309 25 1 1 CD cord-276616-odmnvv7m 309 26 ° ° NN cord-276616-odmnvv7m 309 27 . . . cord-276616-odmnvv7m 310 1 However however RB cord-276616-odmnvv7m 310 2 , , , cord-276616-odmnvv7m 310 3 it -PRON- PRP cord-276616-odmnvv7m 310 4 is be VBZ cord-276616-odmnvv7m 310 5 uncertain uncertain JJ cord-276616-odmnvv7m 310 6 whether whether IN cord-276616-odmnvv7m 310 7 this this DT cord-276616-odmnvv7m 310 8 predisposition predisposition NN cord-276616-odmnvv7m 310 9 of of IN cord-276616-odmnvv7m 310 10 sheep sheep NN cord-276616-odmnvv7m 310 11 to to IN cord-276616-odmnvv7m 310 12 scrapie scrapie NN cord-276616-odmnvv7m 310 13 is be VBZ cord-276616-odmnvv7m 310 14 due due JJ cord-276616-odmnvv7m 310 15 to to IN cord-276616-odmnvv7m 310 16 increased increase VBN cord-276616-odmnvv7m 310 17 exposure exposure NN cord-276616-odmnvv7m 310 18 at at IN cord-276616-odmnvv7m 310 19 time time NN cord-276616-odmnvv7m 310 20 of of IN cord-276616-odmnvv7m 310 21 parturition parturition NN cord-276616-odmnvv7m 310 22 or or CC cord-276616-odmnvv7m 310 23 to to TO cord-276616-odmnvv7m 310 24 gene gene NN cord-276616-odmnvv7m 310 25 - - HYPH cord-276616-odmnvv7m 310 26 dependent dependent JJ cord-276616-odmnvv7m 310 27 susceptibility susceptibility NN cord-276616-odmnvv7m 310 28 . . . cord-276616-odmnvv7m 311 1 There there EX cord-276616-odmnvv7m 311 2 are be VBP cord-276616-odmnvv7m 311 3 specific specific JJ cord-276616-odmnvv7m 311 4 genes gene NNS cord-276616-odmnvv7m 311 5 for for IN cord-276616-odmnvv7m 311 6 susceptibility susceptibility NN cord-276616-odmnvv7m 311 7 to to IN cord-276616-odmnvv7m 311 8 scrapie scrapie NN cord-276616-odmnvv7m 311 9 : : : cord-276616-odmnvv7m 311 10 Sip sip VB cord-276616-odmnvv7m 311 11 , , , cord-276616-odmnvv7m 311 12 which which WDT cord-276616-odmnvv7m 311 13 controls control VBZ cord-276616-odmnvv7m 311 14 the the DT cord-276616-odmnvv7m 311 15 incubation incubation NN cord-276616-odmnvv7m 311 16 period period NN cord-276616-odmnvv7m 311 17 of of IN cord-276616-odmnvv7m 311 18 the the DT cord-276616-odmnvv7m 311 19 disease disease NN cord-276616-odmnvv7m 311 20 in in IN cord-276616-odmnvv7m 311 21 sheep sheep NN cord-276616-odmnvv7m 311 22 , , , cord-276616-odmnvv7m 311 23 and and CC cord-276616-odmnvv7m 311 24 the the DT cord-276616-odmnvv7m 311 25 Sinc Sinc NNP cord-276616-odmnvv7m 311 26 gene gene NN cord-276616-odmnvv7m 311 27 in in IN cord-276616-odmnvv7m 311 28 mice mouse NNS cord-276616-odmnvv7m 311 29 ( ( -LRB- cord-276616-odmnvv7m 311 30 Bradley Bradley NNP cord-276616-odmnvv7m 311 31 and and CC cord-276616-odmnvv7m 311 32 Matthews Matthews NNP cord-276616-odmnvv7m 311 33 , , , cord-276616-odmnvv7m 311 34 1992 1992 CD cord-276616-odmnvv7m 311 35 ; ; : cord-276616-odmnvv7m 311 36 Kimberlin Kimberlin NNP cord-276616-odmnvv7m 311 37 , , , cord-276616-odmnvv7m 311 38 1990 1990 CD cord-276616-odmnvv7m 311 39 ) ) -RRB- cord-276616-odmnvv7m 311 40 . . . cord-276616-odmnvv7m 312 1 Sinc Sinc NNP cord-276616-odmnvv7m 312 2 has have VBZ cord-276616-odmnvv7m 312 3 also also RB cord-276616-odmnvv7m 312 4 been be VBN cord-276616-odmnvv7m 312 5 found find VBN cord-276616-odmnvv7m 312 6 genetically genetically RB cord-276616-odmnvv7m 312 7 linked link VBN cord-276616-odmnvv7m 312 8 to to IN cord-276616-odmnvv7m 312 9 the the DT cord-276616-odmnvv7m 312 10 Prn Prn NNP cord-276616-odmnvv7m 312 11 protein protein NN cord-276616-odmnvv7m 312 12 gene gene NN cord-276616-odmnvv7m 312 13 ( ( -LRB- cord-276616-odmnvv7m 312 14 Hunter Hunter NNP cord-276616-odmnvv7m 312 15 et et NNP cord-276616-odmnvv7m 312 16 al al NNP cord-276616-odmnvv7m 312 17 . . NNP cord-276616-odmnvv7m 312 18 , , , cord-276616-odmnvv7m 312 19 1987 1987 CD cord-276616-odmnvv7m 312 20 ) ) -RRB- cord-276616-odmnvv7m 312 21 . . . cord-276616-odmnvv7m 313 1 The the DT cord-276616-odmnvv7m 313 2 finding finding NN cord-276616-odmnvv7m 313 3 by by IN cord-276616-odmnvv7m 313 4 Deslys Deslys NNP cord-276616-odmnvv7m 313 5 and and CC cord-276616-odmnvv7m 313 6 colleagues colleague NNS cord-276616-odmnvv7m 313 7 ( ( -LRB- cord-276616-odmnvv7m 313 8 1994 1994 CD cord-276616-odmnvv7m 313 9 ) ) -RRB- cord-276616-odmnvv7m 313 10 that that IN cord-276616-odmnvv7m 313 11 all all PDT cord-276616-odmnvv7m 313 12 the the DT cord-276616-odmnvv7m 313 13 cases case NNS cord-276616-odmnvv7m 313 14 of of IN cord-276616-odmnvv7m 313 15 CJD CJD NNP cord-276616-odmnvv7m 313 16 acquired acquire VBN cord-276616-odmnvv7m 313 17 by by IN cord-276616-odmnvv7m 313 18 injections injection NNS cord-276616-odmnvv7m 313 19 of of IN cord-276616-odmnvv7m 313 20 human human JJ cord-276616-odmnvv7m 313 21 growth growth NN cord-276616-odmnvv7m 313 22 hormone hormone NN cord-276616-odmnvv7m 313 23 in in IN cord-276616-odmnvv7m 313 24 25 25 CD cord-276616-odmnvv7m 313 25 French french JJ cord-276616-odmnvv7m 313 26 children child NNS cord-276616-odmnvv7m 313 27 occurred occur VBD cord-276616-odmnvv7m 313 28 in in IN cord-276616-odmnvv7m 313 29 individuals individual NNS cord-276616-odmnvv7m 313 30 who who WP cord-276616-odmnvv7m 313 31 were be VBD cord-276616-odmnvv7m 313 32 homozygous homozygous JJ cord-276616-odmnvv7m 313 33 at at IN cord-276616-odmnvv7m 313 34 codon codon NN cord-276616-odmnvv7m 313 35 129 129 CD cord-276616-odmnvv7m 313 36 of of IN cord-276616-odmnvv7m 313 37 PrP prp NN cord-276616-odmnvv7m 313 38 is be VBZ cord-276616-odmnvv7m 313 39 seen see VBN cord-276616-odmnvv7m 313 40 as as IN cord-276616-odmnvv7m 313 41 support support NN cord-276616-odmnvv7m 313 42 for for IN cord-276616-odmnvv7m 313 43 the the DT cord-276616-odmnvv7m 313 44 importance importance NN cord-276616-odmnvv7m 313 45 of of IN cord-276616-odmnvv7m 313 46 the the DT cord-276616-odmnvv7m 313 47 PrP prp NN cord-276616-odmnvv7m 313 48 gene gene NN cord-276616-odmnvv7m 313 49 in in IN cord-276616-odmnvv7m 313 50 the the DT cord-276616-odmnvv7m 313 51 development development NN cord-276616-odmnvv7m 313 52 of of IN cord-276616-odmnvv7m 313 53 encephalopathies encephalopathy NNS cord-276616-odmnvv7m 313 54 . . . cord-276616-odmnvv7m 314 1 A a DT cord-276616-odmnvv7m 314 2 complication complication NN cord-276616-odmnvv7m 314 3 in in IN cord-276616-odmnvv7m 314 4 the the DT cord-276616-odmnvv7m 314 5 British british JJ cord-276616-odmnvv7m 314 6 outbreak outbreak NN cord-276616-odmnvv7m 314 7 of of IN cord-276616-odmnvv7m 314 8 BSE BSE NNP cord-276616-odmnvv7m 314 9 is be VBZ cord-276616-odmnvv7m 314 10 that that IN cord-276616-odmnvv7m 314 11 the the DT cord-276616-odmnvv7m 314 12 national national JJ cord-276616-odmnvv7m 314 13 gene gene NN cord-276616-odmnvv7m 314 14 pool pool NN cord-276616-odmnvv7m 314 15 among among IN cord-276616-odmnvv7m 314 16 cattle cattle NNS cord-276616-odmnvv7m 314 17 will will MD cord-276616-odmnvv7m 314 18 have have VB cord-276616-odmnvv7m 314 19 changed change VBN cord-276616-odmnvv7m 314 20 over over IN cord-276616-odmnvv7m 314 21 the the DT cord-276616-odmnvv7m 314 22 same same JJ cord-276616-odmnvv7m 314 23 time time NN cord-276616-odmnvv7m 314 24 - - HYPH cord-276616-odmnvv7m 314 25 frame frame NN cord-276616-odmnvv7m 314 26 as as IN cord-276616-odmnvv7m 314 27 the the DT cord-276616-odmnvv7m 314 28 epidemic epidemic NN cord-276616-odmnvv7m 314 29 owing owe VBG cord-276616-odmnvv7m 314 30 to to IN cord-276616-odmnvv7m 314 31 the the DT cord-276616-odmnvv7m 314 32 widespread widespread JJ cord-276616-odmnvv7m 314 33 adoption adoption NN cord-276616-odmnvv7m 314 34 of of IN cord-276616-odmnvv7m 314 35 artificial artificial JJ cord-276616-odmnvv7m 314 36 insemination insemination NN cord-276616-odmnvv7m 314 37 ( ( -LRB- cord-276616-odmnvv7m 314 38 AI AI NNP cord-276616-odmnvv7m 314 39 ) ) -RRB- cord-276616-odmnvv7m 314 40 and and CC cord-276616-odmnvv7m 314 41 embryo embryo NN cord-276616-odmnvv7m 314 42 transfer transfer NN cord-276616-odmnvv7m 314 43 ( ( -LRB- cord-276616-odmnvv7m 314 44 ET ET NNP cord-276616-odmnvv7m 314 45 ) ) -RRB- cord-276616-odmnvv7m 314 46 . . . cord-276616-odmnvv7m 315 1 Perhaps perhaps RB cord-276616-odmnvv7m 315 2 a a DT cord-276616-odmnvv7m 315 3 new new JJ cord-276616-odmnvv7m 315 4 study study NN cord-276616-odmnvv7m 315 5 of of IN cord-276616-odmnvv7m 315 6 the the DT cord-276616-odmnvv7m 315 7 data datum NNS cord-276616-odmnvv7m 315 8 that that WDT cord-276616-odmnvv7m 315 9 have have VBP cord-276616-odmnvv7m 315 10 been be VBN cord-276616-odmnvv7m 315 11 accumulated accumulate VBN cord-276616-odmnvv7m 315 12 on on IN cord-276616-odmnvv7m 315 13 this this DT cord-276616-odmnvv7m 315 14 outbreak outbreak NN cord-276616-odmnvv7m 315 15 might may MD cord-276616-odmnvv7m 315 16 point point VB cord-276616-odmnvv7m 315 17 to to IN cord-276616-odmnvv7m 315 18 certain certain JJ cord-276616-odmnvv7m 315 19 bulls bull NNS cord-276616-odmnvv7m 315 20 or or CC cord-276616-odmnvv7m 315 21 certain certain JJ cord-276616-odmnvv7m 315 22 cows cow NNS cord-276616-odmnvv7m 315 23 that that WDT cord-276616-odmnvv7m 315 24 have have VBP cord-276616-odmnvv7m 315 25 had have VBN cord-276616-odmnvv7m 315 26 an an DT cord-276616-odmnvv7m 315 27 unexpectedly unexpectedly RB cord-276616-odmnvv7m 315 28 high high JJ cord-276616-odmnvv7m 315 29 incidence incidence NN cord-276616-odmnvv7m 315 30 of of IN cord-276616-odmnvv7m 315 31 BSE BSE NNP cord-276616-odmnvv7m 315 32 in in IN cord-276616-odmnvv7m 315 33 their -PRON- PRP$ cord-276616-odmnvv7m 315 34 progeny progeny NN cord-276616-odmnvv7m 315 35 . . . cord-276616-odmnvv7m 316 1 If if IN cord-276616-odmnvv7m 316 2 such such PDT cord-276616-odmnvv7m 316 3 an an DT cord-276616-odmnvv7m 316 4 effect effect NN cord-276616-odmnvv7m 316 5 could could MD cord-276616-odmnvv7m 316 6 be be VB cord-276616-odmnvv7m 316 7 demonstrated demonstrate VBN cord-276616-odmnvv7m 316 8 , , , cord-276616-odmnvv7m 316 9 it -PRON- PRP cord-276616-odmnvv7m 316 10 would would MD cord-276616-odmnvv7m 316 11 mean mean VB cord-276616-odmnvv7m 316 12 either either CC cord-276616-odmnvv7m 316 13 that that IN cord-276616-odmnvv7m 316 14 these these DT cord-276616-odmnvv7m 316 15 cases case NNS cord-276616-odmnvv7m 316 16 have have VBP cord-276616-odmnvv7m 316 17 followed follow VBN cord-276616-odmnvv7m 316 18 the the DT cord-276616-odmnvv7m 316 19 introduction introduction NN cord-276616-odmnvv7m 316 20 of of IN cord-276616-odmnvv7m 316 21 genes gene NNS cord-276616-odmnvv7m 316 22 for for IN cord-276616-odmnvv7m 316 23 susceptibility susceptibility NN cord-276616-odmnvv7m 316 24 into into IN cord-276616-odmnvv7m 316 25 previously previously RB cord-276616-odmnvv7m 316 26 unaffected unaffected JJ cord-276616-odmnvv7m 316 27 herds herd NNS cord-276616-odmnvv7m 316 28 or or CC cord-276616-odmnvv7m 316 29 that that IN cord-276616-odmnvv7m 316 30 actual actual JJ cord-276616-odmnvv7m 316 31 infection infection NN cord-276616-odmnvv7m 316 32 occurred occur VBD cord-276616-odmnvv7m 316 33 through through IN cord-276616-odmnvv7m 316 34 the the DT cord-276616-odmnvv7m 316 35 use use NN cord-276616-odmnvv7m 316 36 of of IN cord-276616-odmnvv7m 316 37 these these DT cord-276616-odmnvv7m 316 38 breeding breeding NN cord-276616-odmnvv7m 316 39 techniques technique NNS cord-276616-odmnvv7m 316 40 . . . cord-276616-odmnvv7m 317 1 Wrathall Wrathall NNP cord-276616-odmnvv7m 317 2 and and CC cord-276616-odmnvv7m 317 3 Brown Brown NNP cord-276616-odmnvv7m 317 4 ( ( -LRB- cord-276616-odmnvv7m 317 5 1991 1991 CD cord-276616-odmnvv7m 317 6 ) ) -RRB- cord-276616-odmnvv7m 317 7 stated state VBD cord-276616-odmnvv7m 317 8 that that IN cord-276616-odmnvv7m 317 9 there there EX cord-276616-odmnvv7m 317 10 is be VBZ cord-276616-odmnvv7m 317 11 no no DT cord-276616-odmnvv7m 317 12 evidence evidence NN cord-276616-odmnvv7m 317 13 to to TO cord-276616-odmnvv7m 317 14 suggest suggest VB cord-276616-odmnvv7m 317 15 that that IN cord-276616-odmnvv7m 317 16 vertical vertical JJ cord-276616-odmnvv7m 317 17 transmission transmission NN cord-276616-odmnvv7m 317 18 of of IN cord-276616-odmnvv7m 317 19 BSE BSE NNP cord-276616-odmnvv7m 317 20 occurs occur VBZ cord-276616-odmnvv7m 317 21 and and CC cord-276616-odmnvv7m 317 22 discussed discuss VBD cord-276616-odmnvv7m 317 23 ET ET NNP cord-276616-odmnvv7m 317 24 and and CC cord-276616-odmnvv7m 317 25 AI AI NNP cord-276616-odmnvv7m 317 26 studies study NNS cord-276616-odmnvv7m 317 27 with with IN cord-276616-odmnvv7m 317 28 scrapie scrapie NN cord-276616-odmnvv7m 317 29 - - HYPH cord-276616-odmnvv7m 317 30 infected infect VBN cord-276616-odmnvv7m 317 31 sheep sheep NN cord-276616-odmnvv7m 317 32 . . . cord-276616-odmnvv7m 318 1 It -PRON- PRP cord-276616-odmnvv7m 318 2 has have VBZ cord-276616-odmnvv7m 318 3 been be VBN cord-276616-odmnvv7m 318 4 thought think VBN cord-276616-odmnvv7m 318 5 that that IN cord-276616-odmnvv7m 318 6 ET ET NNP cord-276616-odmnvv7m 318 7 and and CC cord-276616-odmnvv7m 318 8 AI AI NNP cord-276616-odmnvv7m 318 9 might may MD cord-276616-odmnvv7m 318 10 provide provide VB cord-276616-odmnvv7m 318 11 a a DT cord-276616-odmnvv7m 318 12 means means NN cord-276616-odmnvv7m 318 13 for for IN cord-276616-odmnvv7m 318 14 breaking break VBG cord-276616-odmnvv7m 318 15 the the DT cord-276616-odmnvv7m 318 16 disease disease NN cord-276616-odmnvv7m 318 17 transmission transmission NN cord-276616-odmnvv7m 318 18 cycle cycle NN cord-276616-odmnvv7m 318 19 in in IN cord-276616-odmnvv7m 318 20 scrapie scrapie NN cord-276616-odmnvv7m 318 21 and and CC cord-276616-odmnvv7m 318 22 BSE BSE NNP cord-276616-odmnvv7m 318 23 , , , cord-276616-odmnvv7m 318 24 but but CC cord-276616-odmnvv7m 318 25 such such JJ cord-276616-odmnvv7m 318 26 studies study NNS cord-276616-odmnvv7m 318 27 will will MD cord-276616-odmnvv7m 318 28 be be VB cord-276616-odmnvv7m 318 29 complicated complicate VBN cord-276616-odmnvv7m 318 30 by by IN cord-276616-odmnvv7m 318 31 the the DT cord-276616-odmnvv7m 318 32 existence existence NN cord-276616-odmnvv7m 318 33 of of IN cord-276616-odmnvv7m 318 34 the the DT cord-276616-odmnvv7m 318 35 genes gene NNS cord-276616-odmnvv7m 318 36 for for IN cord-276616-odmnvv7m 318 37 susceptibility susceptibility NN cord-276616-odmnvv7m 318 38 . . . cord-276616-odmnvv7m 319 1 The the DT cord-276616-odmnvv7m 319 2 research research NN cord-276616-odmnvv7m 319 3 done do VBN cord-276616-odmnvv7m 319 4 on on IN cord-276616-odmnvv7m 319 5 the the DT cord-276616-odmnvv7m 319 6 prion prion NN cord-276616-odmnvv7m 319 7 theory theory NN cord-276616-odmnvv7m 319 8 has have VBZ cord-276616-odmnvv7m 319 9 greatly greatly RB cord-276616-odmnvv7m 319 10 expanded expand VBN cord-276616-odmnvv7m 319 11 our -PRON- PRP$ cord-276616-odmnvv7m 319 12 knowledge knowledge NN cord-276616-odmnvv7m 319 13 of of IN cord-276616-odmnvv7m 319 14 these these DT cord-276616-odmnvv7m 319 15 diseases disease NNS cord-276616-odmnvv7m 319 16 , , , cord-276616-odmnvv7m 319 17 but but CC cord-276616-odmnvv7m 319 18 the the DT cord-276616-odmnvv7m 319 19 most most RBS cord-276616-odmnvv7m 319 20 active active JJ cord-276616-odmnvv7m 319 21 promoters promoter NNS cord-276616-odmnvv7m 319 22 of of IN cord-276616-odmnvv7m 319 23 the the DT cord-276616-odmnvv7m 319 24 prion prion NN cord-276616-odmnvv7m 319 25 ask ask VBP cord-276616-odmnvv7m 319 26 us -PRON- PRP cord-276616-odmnvv7m 319 27 to to TO cord-276616-odmnvv7m 319 28 believe believe VB cord-276616-odmnvv7m 319 29 that that IN cord-276616-odmnvv7m 319 30 it -PRON- PRP cord-276616-odmnvv7m 319 31 , , , cord-276616-odmnvv7m 319 32 and and CC cord-276616-odmnvv7m 319 33 its -PRON- PRP$ cord-276616-odmnvv7m 319 34 gene gene NN cord-276616-odmnvv7m 319 35 , , , cord-276616-odmnvv7m 319 36 can can MD cord-276616-odmnvv7m 319 37 cause cause VB cord-276616-odmnvv7m 319 38 the the DT cord-276616-odmnvv7m 319 39 encephalopathies encephalopathy NNS cord-276616-odmnvv7m 319 40 , , , cord-276616-odmnvv7m 319 41 that that IN cord-276616-odmnvv7m 319 42 it -PRON- PRP cord-276616-odmnvv7m 319 43 is be VBZ cord-276616-odmnvv7m 319 44 responsible responsible JJ cord-276616-odmnvv7m 319 45 for for IN cord-276616-odmnvv7m 319 46 the the DT cord-276616-odmnvv7m 319 47 predisposition predisposition NN cord-276616-odmnvv7m 319 48 to to IN cord-276616-odmnvv7m 319 49 and and CC cord-276616-odmnvv7m 319 50 the the DT cord-276616-odmnvv7m 319 51 pathogenesis pathogenesis NN cord-276616-odmnvv7m 319 52 of of IN cord-276616-odmnvv7m 319 53 these these DT cord-276616-odmnvv7m 319 54 diseases disease NNS cord-276616-odmnvv7m 319 55 , , , cord-276616-odmnvv7m 319 56 and and CC cord-276616-odmnvv7m 319 57 that that IN cord-276616-odmnvv7m 319 58 it -PRON- PRP cord-276616-odmnvv7m 319 59 can can MD cord-276616-odmnvv7m 319 60 ensure ensure VB cord-276616-odmnvv7m 319 61 its -PRON- PRP$ cord-276616-odmnvv7m 319 62 own own JJ cord-276616-odmnvv7m 319 63 replication replication NN cord-276616-odmnvv7m 319 64 . . . cord-276616-odmnvv7m 320 1 Much much RB cord-276616-odmnvv7m 320 2 more more RBR cord-276616-odmnvv7m 320 3 controlled control VBN cord-276616-odmnvv7m 320 4 work work NN cord-276616-odmnvv7m 320 5 on on IN cord-276616-odmnvv7m 320 6 the the DT cord-276616-odmnvv7m 320 7 prion prion NN cord-276616-odmnvv7m 320 8 is be VBZ cord-276616-odmnvv7m 320 9 necessary necessary JJ cord-276616-odmnvv7m 320 10 before before IN cord-276616-odmnvv7m 320 11 conclusions conclusion NNS cord-276616-odmnvv7m 320 12 of of IN cord-276616-odmnvv7m 320 13 this this DT cord-276616-odmnvv7m 320 14 kind kind NN cord-276616-odmnvv7m 320 15 can can MD cord-276616-odmnvv7m 320 16 be be VB cord-276616-odmnvv7m 320 17 justified justify VBN cord-276616-odmnvv7m 320 18 . . . cord-276616-odmnvv7m 321 1 For for IN cord-276616-odmnvv7m 321 2 instance instance NN cord-276616-odmnvv7m 321 3 , , , cord-276616-odmnvv7m 321 4 can can MD cord-276616-odmnvv7m 321 5 the the DT cord-276616-odmnvv7m 321 6 material material NN cord-276616-odmnvv7m 321 7 of of IN cord-276616-odmnvv7m 321 8 which which WDT cord-276616-odmnvv7m 321 9 prions prion NNS cord-276616-odmnvv7m 321 10 are be VBP cord-276616-odmnvv7m 321 11 a a DT cord-276616-odmnvv7m 321 12 component component NN cord-276616-odmnvv7m 321 13 ( ( -LRB- cord-276616-odmnvv7m 321 14 SAF SAF NNP cord-276616-odmnvv7m 321 15 ) ) -RRB- cord-276616-odmnvv7m 321 16 act act VBP cord-276616-odmnvv7m 321 17 as as IN cord-276616-odmnvv7m 321 18 a a DT cord-276616-odmnvv7m 321 19 viral viral JJ cord-276616-odmnvv7m 321 20 promoter promoter NN cord-276616-odmnvv7m 321 21 of of IN cord-276616-odmnvv7m 321 22 other other JJ cord-276616-odmnvv7m 321 23 neurotropic neurotropic NNP cord-276616-odmnvv7m 321 24 viruses virus NNS cord-276616-odmnvv7m 321 25 ? ? . cord-276616-odmnvv7m 322 1 An an DT cord-276616-odmnvv7m 322 2 investigation investigation NN cord-276616-odmnvv7m 322 3 of of IN cord-276616-odmnvv7m 322 4 such such PDT cord-276616-odmnvv7m 322 5 a a DT cord-276616-odmnvv7m 322 6 possibility possibility NN cord-276616-odmnvv7m 322 7 would would MD cord-276616-odmnvv7m 322 8 seem seem VB cord-276616-odmnvv7m 322 9 to to TO cord-276616-odmnvv7m 322 10 be be VB cord-276616-odmnvv7m 322 11 essential essential JJ cord-276616-odmnvv7m 322 12 in in IN cord-276616-odmnvv7m 322 13 understanding understand VBG cord-276616-odmnvv7m 322 14 the the DT cord-276616-odmnvv7m 322 15 role role NN cord-276616-odmnvv7m 322 16 that that WDT cord-276616-odmnvv7m 322 17 the the DT cord-276616-odmnvv7m 322 18 prion prion NN cord-276616-odmnvv7m 322 19 plays play VBZ cord-276616-odmnvv7m 322 20 . . . cord-276616-odmnvv7m 323 1 Studies study NNS cord-276616-odmnvv7m 323 2 with with IN cord-276616-odmnvv7m 323 3 known know VBN cord-276616-odmnvv7m 323 4 neurotropic neurotropic NNP cord-276616-odmnvv7m 323 5 viruses virus NNS cord-276616-odmnvv7m 323 6 , , , cord-276616-odmnvv7m 323 7 with with IN cord-276616-odmnvv7m 323 8 the the DT cord-276616-odmnvv7m 323 9 viruses virus NNS cord-276616-odmnvv7m 323 10 given give VBN cord-276616-odmnvv7m 323 11 in in IN cord-276616-odmnvv7m 323 12 the the DT cord-276616-odmnvv7m 323 13 presence presence NN cord-276616-odmnvv7m 323 14 and and CC cord-276616-odmnvv7m 323 15 absence absence NN cord-276616-odmnvv7m 323 16 of of IN cord-276616-odmnvv7m 323 17 SAF SAF NNP cord-276616-odmnvv7m 323 18 , , , cord-276616-odmnvv7m 323 19 should should MD cord-276616-odmnvv7m 323 20 show show VB cord-276616-odmnvv7m 323 21 whether whether IN cord-276616-odmnvv7m 323 22 this this DT cord-276616-odmnvv7m 323 23 material material NN cord-276616-odmnvv7m 323 24 can can MD cord-276616-odmnvv7m 323 25 have have VB cord-276616-odmnvv7m 323 26 a a DT cord-276616-odmnvv7m 323 27 promoter promoter NN cord-276616-odmnvv7m 323 28 effect effect NN cord-276616-odmnvv7m 323 29 . . . cord-276616-odmnvv7m 324 1 Tile tile JJ cord-276616-odmnvv7m 324 2 quotation quotation NN cord-276616-odmnvv7m 324 3 at at IN cord-276616-odmnvv7m 324 4 the the DT cord-276616-odmnvv7m 324 5 beginning beginning NN cord-276616-odmnvv7m 324 6 of of IN cord-276616-odmnvv7m 324 7 this this DT cord-276616-odmnvv7m 324 8 article article NN cord-276616-odmnvv7m 324 9 describes describe VBZ cord-276616-odmnvv7m 324 10 workers worker NNS cord-276616-odmnvv7m 324 11 in in IN cord-276616-odmnvv7m 324 12 the the DT cord-276616-odmnvv7m 324 13 field field NN cord-276616-odmnvv7m 324 14 of of IN cord-276616-odmnvv7m 324 15 the the DT cord-276616-odmnvv7m 324 16 encephalopathies encephalopathy NNS cord-276616-odmnvv7m 324 17 very very RB cord-276616-odmnvv7m 324 18 well well RB cord-276616-odmnvv7m 324 19 , , , cord-276616-odmnvv7m 324 20 each each DT cord-276616-odmnvv7m 324 21 interested interested JJ cord-276616-odmnvv7m 324 22 in in IN cord-276616-odmnvv7m 324 23 their -PRON- PRP$ cord-276616-odmnvv7m 324 24 own own JJ cord-276616-odmnvv7m 324 25 particular particular JJ cord-276616-odmnvv7m 324 26 area area NN cord-276616-odmnvv7m 324 27 . . . cord-276616-odmnvv7m 325 1 In in IN cord-276616-odmnvv7m 325 2 the the DT cord-276616-odmnvv7m 325 3 author author NN cord-276616-odmnvv7m 325 4 's 's POS cord-276616-odmnvv7m 325 5 case case NN cord-276616-odmnvv7m 325 6 , , , cord-276616-odmnvv7m 325 7 the the DT cord-276616-odmnvv7m 325 8 bias bias NN cord-276616-odmnvv7m 325 9 is be VBZ cord-276616-odmnvv7m 325 10 towards towards IN cord-276616-odmnvv7m 325 11 viruses virus NNS cord-276616-odmnvv7m 325 12 being be VBG cord-276616-odmnvv7m 325 13 involved involve VBN cord-276616-odmnvv7m 325 14 in in IN cord-276616-odmnvv7m 325 15 the the DT cord-276616-odmnvv7m 325 16 causation causation NN cord-276616-odmnvv7m 325 17 of of IN cord-276616-odmnvv7m 325 18 these these DT cord-276616-odmnvv7m 325 19 diseases disease NNS cord-276616-odmnvv7m 325 20 . . . cord-276616-odmnvv7m 326 1 In in IN cord-276616-odmnvv7m 326 2 considering consider VBG cord-276616-odmnvv7m 326 3 the the DT cord-276616-odmnvv7m 326 4 experimental experimental JJ cord-276616-odmnvv7m 326 5 work work NN cord-276616-odmnvv7m 326 6 that that WDT cord-276616-odmnvv7m 326 7 has have VBZ cord-276616-odmnvv7m 326 8 been be VBN cord-276616-odmnvv7m 326 9 done do VBN cord-276616-odmnvv7m 326 10 , , , cord-276616-odmnvv7m 326 11 the the DT cord-276616-odmnvv7m 326 12 differences difference NNS cord-276616-odmnvv7m 326 13 in in IN cord-276616-odmnvv7m 326 14 the the DT cord-276616-odmnvv7m 326 15 biological biological JJ cord-276616-odmnvv7m 326 16 activities activity NNS cord-276616-odmnvv7m 326 17 of of IN cord-276616-odmnvv7m 326 18 the the DT cord-276616-odmnvv7m 326 19 isolates isolate NNS cord-276616-odmnvv7m 326 20 of of IN cord-276616-odmnvv7m 326 21 the the DT cord-276616-odmnvv7m 326 22 transmissible transmissible JJ cord-276616-odmnvv7m 326 23 encephalopathies encephalopathy NNS cord-276616-odmnvv7m 326 24 are be VBP cord-276616-odmnvv7m 326 25 impressive impressive JJ cord-276616-odmnvv7m 326 26 . . . cord-276616-odmnvv7m 327 1 If if IN cord-276616-odmnvv7m 327 2 BSE BSE NNP cord-276616-odmnvv7m 327 3 were be VBD cord-276616-odmnvv7m 327 4 really really RB cord-276616-odmnvv7m 327 5 a a DT cord-276616-odmnvv7m 327 6 manifestation manifestation NN cord-276616-odmnvv7m 327 7 of of IN cord-276616-odmnvv7m 327 8 transmitted transmit VBN cord-276616-odmnvv7m 327 9 scrapie scrapie NN cord-276616-odmnvv7m 327 10 , , , cord-276616-odmnvv7m 327 11 one one PRP cord-276616-odmnvv7m 327 12 would would MD cord-276616-odmnvv7m 327 13 expect expect VB cord-276616-odmnvv7m 327 14 to to TO cord-276616-odmnvv7m 327 15 find find VB cord-276616-odmnvv7m 327 16 that that IN cord-276616-odmnvv7m 327 17 its -PRON- PRP$ cord-276616-odmnvv7m 327 18 isolates isolate NNS cord-276616-odmnvv7m 327 19 behaved behave VBN cord-276616-odmnvv7m 327 20 with with IN cord-276616-odmnvv7m 327 21 the the DT cord-276616-odmnvv7m 327 22 variability variability NN cord-276616-odmnvv7m 327 23 shown show VBN cord-276616-odmnvv7m 327 24 by by IN cord-276616-odmnvv7m 327 25 scrapie scrapie NN cord-276616-odmnvv7m 327 26 isolates isolate NNS cord-276616-odmnvv7m 327 27 . . . cord-276616-odmnvv7m 328 1 This this DT cord-276616-odmnvv7m 328 2 does do VBZ cord-276616-odmnvv7m 328 3 not not RB cord-276616-odmnvv7m 328 4 occur occur VB cord-276616-odmnvv7m 328 5 . . . cord-276616-odmnvv7m 329 1 Not not RB cord-276616-odmnvv7m 329 2 knowing know VBG cord-276616-odmnvv7m 329 3 the the DT cord-276616-odmnvv7m 329 4 cause cause NN cord-276616-odmnvv7m 329 5 of of IN cord-276616-odmnvv7m 329 6 the the DT cord-276616-odmnvv7m 329 7 transmissible transmissible JJ cord-276616-odmnvv7m 329 8 encephalopathies encephalopathy NNS cord-276616-odmnvv7m 329 9 makes make VBZ cord-276616-odmnvv7m 329 10 the the DT cord-276616-odmnvv7m 329 11 approach approach NN cord-276616-odmnvv7m 329 12 to to IN cord-276616-odmnvv7m 329 13 controlling control VBG cord-276616-odmnvv7m 329 14 these these DT cord-276616-odmnvv7m 329 15 diseases disease NNS cord-276616-odmnvv7m 329 16 very very RB cord-276616-odmnvv7m 329 17 difficult difficult JJ cord-276616-odmnvv7m 329 18 . . . cord-276616-odmnvv7m 330 1 The the DT cord-276616-odmnvv7m 330 2 outbreak outbreak NN cord-276616-odmnvv7m 330 3 of of IN cord-276616-odmnvv7m 330 4 BSE BSE NNP cord-276616-odmnvv7m 330 5 in in IN cord-276616-odmnvv7m 330 6 Britain Britain NNP cord-276616-odmnvv7m 330 7 has have VBZ cord-276616-odmnvv7m 330 8 disrupted disrupt VBN cord-276616-odmnvv7m 330 9 the the DT cord-276616-odmnvv7m 330 10 export export NN cord-276616-odmnvv7m 330 11 of of IN cord-276616-odmnvv7m 330 12 pedigree pedigree JJ cord-276616-odmnvv7m 330 13 cattle cattle NNS cord-276616-odmnvv7m 330 14 , , , cord-276616-odmnvv7m 330 15 and and CC cord-276616-odmnvv7m 330 16 there there EX cord-276616-odmnvv7m 330 17 were be VBD cord-276616-odmnvv7m 330 18 other other JJ cord-276616-odmnvv7m 330 19 ramifications ramification NNS cord-276616-odmnvv7m 330 20 . . . cord-276616-odmnvv7m 331 1 There there EX cord-276616-odmnvv7m 331 2 is be VBZ cord-276616-odmnvv7m 331 3 the the DT cord-276616-odmnvv7m 331 4 concern concern NN cord-276616-odmnvv7m 331 5 , , , cord-276616-odmnvv7m 331 6 not not RB cord-276616-odmnvv7m 331 7 substantiated substantiate VBN cord-276616-odmnvv7m 331 8 , , , cord-276616-odmnvv7m 331 9 that that IN cord-276616-odmnvv7m 331 10 once once RB cord-276616-odmnvv7m 331 11 transmitted transmit VBN cord-276616-odmnvv7m 331 12 to to IN cord-276616-odmnvv7m 331 13 a a DT cord-276616-odmnvv7m 331 14 new new JJ cord-276616-odmnvv7m 331 15 species specie NNS cord-276616-odmnvv7m 331 16 , , , cord-276616-odmnvv7m 331 17 such such JJ cord-276616-odmnvv7m 331 18 as as IN cord-276616-odmnvv7m 331 19 bovine bovine JJ cord-276616-odmnvv7m 331 20 , , , cord-276616-odmnvv7m 331 21 the the DT cord-276616-odmnvv7m 331 22 agent agent NN cord-276616-odmnvv7m 331 23 might may MD cord-276616-odmnvv7m 331 24 persist persist VB cord-276616-odmnvv7m 331 25 in in IN cord-276616-odmnvv7m 331 26 the the DT cord-276616-odmnvv7m 331 27 new new JJ cord-276616-odmnvv7m 331 28 species specie NNS cord-276616-odmnvv7m 331 29 . . . cord-276616-odmnvv7m 332 1 There there EX cord-276616-odmnvv7m 332 2 are be VBP cord-276616-odmnvv7m 332 3 also also RB cord-276616-odmnvv7m 332 4 fears fear NNS cord-276616-odmnvv7m 332 5 that that IN cord-276616-odmnvv7m 332 6 the the DT cord-276616-odmnvv7m 332 7 disease disease NN cord-276616-odmnvv7m 332 8 might may MD cord-276616-odmnvv7m 332 9 become become VB cord-276616-odmnvv7m 332 10 established establish VBN cord-276616-odmnvv7m 332 11 in in IN cord-276616-odmnvv7m 332 12 other other JJ cord-276616-odmnvv7m 332 13 countries country NNS cord-276616-odmnvv7m 332 14 and and CC cord-276616-odmnvv7m 332 15 cross cross VB cord-276616-odmnvv7m 332 16 the the DT cord-276616-odmnvv7m 332 17 species specie NNS cord-276616-odmnvv7m 332 18 boundary boundary NN cord-276616-odmnvv7m 332 19 to to IN cord-276616-odmnvv7m 332 20 man man NN cord-276616-odmnvv7m 332 21 . . . cord-276616-odmnvv7m 333 1 The the DT cord-276616-odmnvv7m 333 2 expenditure expenditure NN cord-276616-odmnvv7m 333 3 of of IN cord-276616-odmnvv7m 333 4 money money NN cord-276616-odmnvv7m 333 5 for for IN cord-276616-odmnvv7m 333 6 research research NN cord-276616-odmnvv7m 333 7 on on IN cord-276616-odmnvv7m 333 8 the the DT cord-276616-odmnvv7m 333 9 encephalopathies encephalopathy NNS cord-276616-odmnvv7m 333 10 is be VBZ cord-276616-odmnvv7m 333 11 therefore therefore RB cord-276616-odmnvv7m 333 12 justified justify VBN cord-276616-odmnvv7m 333 13 from from IN cord-276616-odmnvv7m 333 14 the the DT cord-276616-odmnvv7m 333 15 agricultural agricultural JJ cord-276616-odmnvv7m 333 16 standpoint standpoint NN cord-276616-odmnvv7m 333 17 alone alone RB cord-276616-odmnvv7m 333 18 , , , cord-276616-odmnvv7m 333 19 and and CC cord-276616-odmnvv7m 333 20 the the DT cord-276616-odmnvv7m 333 21 present present JJ cord-276616-odmnvv7m 333 22 paper paper NN cord-276616-odmnvv7m 333 23 has have VBZ cord-276616-odmnvv7m 333 24 tried try VBN cord-276616-odmnvv7m 333 25 to to TO cord-276616-odmnvv7m 333 26 suggest suggest VB cord-276616-odmnvv7m 333 27 areas area NNS cord-276616-odmnvv7m 333 28 that that WDT cord-276616-odmnvv7m 333 29 are be VBP cord-276616-odmnvv7m 333 30 suitable suitable JJ cord-276616-odmnvv7m 333 31 for for IN cord-276616-odmnvv7m 333 32 further further JJ cord-276616-odmnvv7m 333 33 exploration exploration NN cord-276616-odmnvv7m 333 34 . . . cord-276616-odmnvv7m 334 1 One one CD cord-276616-odmnvv7m 334 2 interpretation interpretation NN cord-276616-odmnvv7m 334 3 of of IN cord-276616-odmnvv7m 334 4 the the DT cord-276616-odmnvv7m 334 5 cause cause NN cord-276616-odmnvv7m 334 6 of of IN cord-276616-odmnvv7m 334 7 the the DT cord-276616-odmnvv7m 334 8 outbreaks outbreak NNS cord-276616-odmnvv7m 334 9 of of IN cord-276616-odmnvv7m 334 10 scrapie scrapie NN cord-276616-odmnvv7m 334 11 , , , cord-276616-odmnvv7m 334 12 TME TME NNP cord-276616-odmnvv7m 334 13 and and CC cord-276616-odmnvv7m 334 14 BSE BSE NNP cord-276616-odmnvv7m 334 15 noted note VBD cord-276616-odmnvv7m 334 16 in in IN cord-276616-odmnvv7m 334 17 this this DT cord-276616-odmnvv7m 334 18 paper paper NN cord-276616-odmnvv7m 334 19 is be VBZ cord-276616-odmnvv7m 334 20 that that IN cord-276616-odmnvv7m 334 21 material material NN cord-276616-odmnvv7m 334 22 in in IN cord-276616-odmnvv7m 334 23 the the DT cord-276616-odmnvv7m 334 24 feed feed NN cord-276616-odmnvv7m 334 25 or or CC cord-276616-odmnvv7m 334 26 in in IN cord-276616-odmnvv7m 334 27 the the DT cord-276616-odmnvv7m 334 28 inoculum inoculum NN cord-276616-odmnvv7m 334 29 triggered trigger VBD cord-276616-odmnvv7m 334 30 the the DT cord-276616-odmnvv7m 334 31 growth growth NN cord-276616-odmnvv7m 334 32 of of IN cord-276616-odmnvv7m 334 33 a a DT cord-276616-odmnvv7m 334 34 quiescent quiescent JJ cord-276616-odmnvv7m 334 35 but but CC cord-276616-odmnvv7m 334 36 unrecognized unrecognized JJ cord-276616-odmnvv7m 334 37 virus virus NN cord-276616-odmnvv7m 334 38 . . . cord-276616-odmnvv7m 335 1 Is be VBZ cord-276616-odmnvv7m 335 2 such such JJ cord-276616-odmnvv7m 335 3 triggering triggering NN cord-276616-odmnvv7m 335 4 of of IN cord-276616-odmnvv7m 335 5 a a DT cord-276616-odmnvv7m 335 6 quiescent quiescent JJ cord-276616-odmnvv7m 335 7 virus virus NN cord-276616-odmnvv7m 335 8 possible possible JJ cord-276616-odmnvv7m 335 9 ? ? . cord-276616-odmnvv7m 336 1 We -PRON- PRP cord-276616-odmnvv7m 336 2 know know VBP cord-276616-odmnvv7m 336 3 that that DT cord-276616-odmnvv7m 336 4 contact contact NN cord-276616-odmnvv7m 336 5 with with IN cord-276616-odmnvv7m 336 6 certain certain JJ cord-276616-odmnvv7m 336 7 compounds compound NNS cord-276616-odmnvv7m 336 8 can can MD cord-276616-odmnvv7m 336 9 lead lead VB cord-276616-odmnvv7m 336 10 to to IN cord-276616-odmnvv7m 336 11 the the DT cord-276616-odmnvv7m 336 12 multiplication multiplication NN cord-276616-odmnvv7m 336 13 of of IN cord-276616-odmnvv7m 336 14 latent latent JJ cord-276616-odmnvv7m 336 15 oncornaviruses oncornaviruse NNS cord-276616-odmnvv7m 336 16 ( ( -LRB- cord-276616-odmnvv7m 336 17 Robinson Robinson NNP cord-276616-odmnvv7m 336 18 et et NNP cord-276616-odmnvv7m 336 19 aL aL NNP cord-276616-odmnvv7m 336 20 , , , cord-276616-odmnvv7m 336 21 1976 1976 CD cord-276616-odmnvv7m 336 22 ) ) -RRB- cord-276616-odmnvv7m 336 23 and and CC cord-276616-odmnvv7m 336 24 that that IN cord-276616-odmnvv7m 336 25 corticosteroids corticosteroid NNS cord-276616-odmnvv7m 336 26 can can MD cord-276616-odmnvv7m 336 27 provoke provoke VB cord-276616-odmnvv7m 336 28 the the DT cord-276616-odmnvv7m 336 29 emergence emergence NN cord-276616-odmnvv7m 336 30 of of IN cord-276616-odmnvv7m 336 31 viral viral JJ cord-276616-odmnvv7m 336 32 activity activity NN cord-276616-odmnvv7m 336 33 with with IN cord-276616-odmnvv7m 336 34 latent latent JJ cord-276616-odmnvv7m 336 35 herpesvirus herpesvirus NN cord-276616-odmnvv7m 336 36 infections infection NNS cord-276616-odmnvv7m 336 37 ( ( -LRB- cord-276616-odmnvv7m 336 38 Darcel Darcel NNP cord-276616-odmnvv7m 336 39 and and CC cord-276616-odmnvv7m 336 40 Dorward Dorward NNP cord-276616-odmnvv7m 336 41 , , , cord-276616-odmnvv7m 336 42 1975 1975 CD cord-276616-odmnvv7m 336 43 ; ; : cord-276616-odmnvv7m 336 44 Fenner Fenner NNP cord-276616-odmnvv7m 336 45 et et NNP cord-276616-odmnvv7m 336 46 aL aL NNP cord-276616-odmnvv7m 336 47 , , , cord-276616-odmnvv7m 336 48 1987 1987 CD cord-276616-odmnvv7m 336 49 ) ) -RRB- cord-276616-odmnvv7m 336 50 . . . cord-276616-odmnvv7m 337 1 Other other JJ cord-276616-odmnvv7m 337 2 mechanisms mechanism NNS cord-276616-odmnvv7m 337 3 may may MD cord-276616-odmnvv7m 337 4 also also RB cord-276616-odmnvv7m 337 5 exist exist VB cord-276616-odmnvv7m 337 6 for for IN cord-276616-odmnvv7m 337 7 the the DT cord-276616-odmnvv7m 337 8 stimulation stimulation NN cord-276616-odmnvv7m 337 9 of of IN cord-276616-odmnvv7m 337 10 virus virus NN cord-276616-odmnvv7m 337 11 growth growth NN cord-276616-odmnvv7m 337 12 . . . cord-276616-odmnvv7m 338 1 It -PRON- PRP cord-276616-odmnvv7m 338 2 is be VBZ cord-276616-odmnvv7m 338 3 peculiar peculiar JJ cord-276616-odmnvv7m 338 4 how how WRB cord-276616-odmnvv7m 338 5 refractory refractory JJ cord-276616-odmnvv7m 338 6 the the DT cord-276616-odmnvv7m 338 7 transmissible transmissible JJ cord-276616-odmnvv7m 338 8 spongiform spongiform JJ cord-276616-odmnvv7m 338 9 encephalopathies encephalopathy NNS cord-276616-odmnvv7m 338 10 are be VBP cord-276616-odmnvv7m 338 11 to to IN cord-276616-odmnvv7m 338 12 investigation investigation NN cord-276616-odmnvv7m 338 13 , , , cord-276616-odmnvv7m 338 14 and and CC cord-276616-odmnvv7m 338 15 a a DT cord-276616-odmnvv7m 338 16 real real JJ cord-276616-odmnvv7m 338 17 understanding understanding NN cord-276616-odmnvv7m 338 18 of of IN cord-276616-odmnvv7m 338 19 their -PRON- PRP$ cord-276616-odmnvv7m 338 20 causation causation NN cord-276616-odmnvv7m 338 21 is be VBZ cord-276616-odmnvv7m 338 22 still still RB cord-276616-odmnvv7m 338 23 elusive elusive JJ cord-276616-odmnvv7m 338 24 . . . cord-276616-odmnvv7m 339 1 Yet yet RB cord-276616-odmnvv7m 339 2 , , , cord-276616-odmnvv7m 339 3 with with IN cord-276616-odmnvv7m 339 4 research research NN cord-276616-odmnvv7m 339 5 , , , cord-276616-odmnvv7m 339 6 there there EX cord-276616-odmnvv7m 339 7 is be VBZ cord-276616-odmnvv7m 339 8 a a DT cord-276616-odmnvv7m 339 9 chance chance NN cord-276616-odmnvv7m 339 10 of of IN cord-276616-odmnvv7m 339 11 discovering discover VBG cord-276616-odmnvv7m 339 12 new new JJ cord-276616-odmnvv7m 339 13 types type NNS cord-276616-odmnvv7m 339 14 of of IN cord-276616-odmnvv7m 339 15 disease disease NN cord-276616-odmnvv7m 339 16 agents agent NNS cord-276616-odmnvv7m 339 17 and and CC cord-276616-odmnvv7m 339 18 learning learn VBG cord-276616-odmnvv7m 339 19 much much JJ cord-276616-odmnvv7m 339 20 about about IN cord-276616-odmnvv7m 339 21 the the DT cord-276616-odmnvv7m 339 22 nature nature NN cord-276616-odmnvv7m 339 23 of of IN cord-276616-odmnvv7m 339 24 important important JJ cord-276616-odmnvv7m 339 25 neurological neurological JJ cord-276616-odmnvv7m 339 26 diseases disease NNS cord-276616-odmnvv7m 339 27 . . . cord-276616-odmnvv7m 340 1 2 2 LS cord-276616-odmnvv7m 340 2 . . . cord-276616-odmnvv7m 341 1 Autophagic Autophagic NNP cord-276616-odmnvv7m 341 2 vacuoles vacuole NNS cord-276616-odmnvv7m 341 3 in in IN cord-276616-odmnvv7m 341 4 mice mouse NNS cord-276616-odmnvv7m 341 5 , , , cord-276616-odmnvv7m 341 6 with with IN cord-276616-odmnvv7m 341 7 sequestered sequester VBN cord-276616-odmnvv7m 341 8 cytoplasmic cytoplasmic JJ cord-276616-odmnvv7m 341 9 areas area NNS cord-276616-odmnvv7m 341 10 containing contain VBG cord-276616-odmnvv7m 341 11 ribosomes ribosome NNS cord-276616-odmnvv7m 341 12 and and CC cord-276616-odmnvv7m 341 13 occasionally occasionally RB cord-276616-odmnvv7m 341 14 mitochondria mitochondrion NNS cord-276616-odmnvv7m 341 15 and and CC cord-276616-odmnvv7m 341 16 small small JJ cord-276616-odmnvv7m 341 17 secondary secondary JJ cord-276616-odmnvv7m 341 18 vacuoles vacuole NNS cord-276616-odmnvv7m 341 19 , , , cord-276616-odmnvv7m 341 20 have have VBP cord-276616-odmnvv7m 341 21 been be VBN cord-276616-odmnvv7m 341 22 described describe VBN cord-276616-odmnvv7m 341 23 in in IN cord-276616-odmnvv7m 341 24 neuronal neuronal JJ cord-276616-odmnvv7m 341 25 perikarya perikarya NN cord-276616-odmnvv7m 341 26 and and CC cord-276616-odmnvv7m 341 27 neuronal neuronal JJ cord-276616-odmnvv7m 341 28 processes process NNS cord-276616-odmnvv7m 341 29 of of IN cord-276616-odmnvv7m 341 30 mice mouse NNS cord-276616-odmnvv7m 341 31 with with IN cord-276616-odmnvv7m 341 32 experimental experimental JJ cord-276616-odmnvv7m 341 33 scrapie scrapie NN cord-276616-odmnvv7m 341 34 and and CC cord-276616-odmnvv7m 341 35 CJD CJD NNP cord-276616-odmnvv7m 341 36 ( ( -LRB- cord-276616-odmnvv7m 341 37 Liberski Liberski NNP cord-276616-odmnvv7m 341 38 et et NNP cord-276616-odmnvv7m 341 39 aL aL NNP cord-276616-odmnvv7m 341 40 , , , cord-276616-odmnvv7m 341 41 1992 1992 CD cord-276616-odmnvv7m 341 42 ) ) -RRB- cord-276616-odmnvv7m 341 43 . . . cord-276616-odmnvv7m 342 1 There there EX cord-276616-odmnvv7m 342 2 seems seem VBZ cord-276616-odmnvv7m 342 3 to to TO cord-276616-odmnvv7m 342 4 be be VB cord-276616-odmnvv7m 342 5 a a DT cord-276616-odmnvv7m 342 6 renewed renew VBN cord-276616-odmnvv7m 342 7 interest interest NN cord-276616-odmnvv7m 342 8 in in IN cord-276616-odmnvv7m 342 9 these these DT cord-276616-odmnvv7m 342 10 neuropil neuropil NN cord-276616-odmnvv7m 342 11 and and CC cord-276616-odmnvv7m 342 12 neuronal neuronal JJ cord-276616-odmnvv7m 342 13 vacuolations vacuolation NNS cord-276616-odmnvv7m 342 14 in in IN cord-276616-odmnvv7m 342 15 circumscribed circumscribed JJ cord-276616-odmnvv7m 342 16 areas area NNS cord-276616-odmnvv7m 342 17 of of IN cord-276616-odmnvv7m 342 18 the the DT cord-276616-odmnvv7m 342 19 brain brain NN cord-276616-odmnvv7m 342 20 , , , cord-276616-odmnvv7m 342 21 with with IN cord-276616-odmnvv7m 342 22 both both DT cord-276616-odmnvv7m 342 23 scrapie scrapie NN cord-276616-odmnvv7m 342 24 and and CC cord-276616-odmnvv7m 342 25 BSE BSE NNP cord-276616-odmnvv7m 342 26 ( ( -LRB- cord-276616-odmnvv7m 342 27 Shinagawa Shinagawa NNP cord-276616-odmnvv7m 342 28 et et FW cord-276616-odmnvv7m 342 29 aL aL NNP cord-276616-odmnvv7m 342 30 , , , cord-276616-odmnvv7m 342 31 1985 1985 CD cord-276616-odmnvv7m 342 32 ; ; : cord-276616-odmnvv7m 343 1 Sasaki Sasaki NNP cord-276616-odmnvv7m 343 2 et et NNP cord-276616-odmnvv7m 343 3 aL aL NNP cord-276616-odmnvv7m 343 4 , , , cord-276616-odmnvv7m 343 5 1986 1986 CD cord-276616-odmnvv7m 343 6 ; ; : cord-276616-odmnvv7m 343 7 Wells Wells NNP cord-276616-odmnvv7m 343 8 et et NNP cord-276616-odmnvv7m 343 9 aL aL NNP cord-276616-odmnvv7m 343 10 , , , cord-276616-odmnvv7m 343 11 1987 1987 CD cord-276616-odmnvv7m 343 12 ; ; : cord-276616-odmnvv7m 343 13 Wells Wells NNP cord-276616-odmnvv7m 343 14 and and CC cord-276616-odmnvv7m 343 15 Wilesmith Wilesmith NNP cord-276616-odmnvv7m 343 16 , , , cord-276616-odmnvv7m 343 17 1989 1989 CD cord-276616-odmnvv7m 343 18 ; ; : cord-276616-odmnvv7m 343 19 Liberski Liberski NNP cord-276616-odmnvv7m 343 20 , , , cord-276616-odmnvv7m 343 21 1990 1990 CD cord-276616-odmnvv7m 343 22 ; ; : cord-276616-odmnvv7m 343 23 Scott Scott NNP cord-276616-odmnvv7m 343 24 et et NNP cord-276616-odmnvv7m 343 25 aL aL NNP cord-276616-odmnvv7m 343 26 , , , cord-276616-odmnvv7m 343 27 1990 1990 CD cord-276616-odmnvv7m 343 28 ) ) -RRB- cord-276616-odmnvv7m 343 29 . . . cord-276616-odmnvv7m 344 1 3 3 LS cord-276616-odmnvv7m 344 2 . . . cord-276616-odmnvv7m 345 1 Further further JJ cord-276616-odmnvv7m 345 2 references reference NNS cord-276616-odmnvv7m 345 3 to to IN cord-276616-odmnvv7m 345 4 Lhermite Lhermite NNP cord-276616-odmnvv7m 345 5 's 's POS cord-276616-odmnvv7m 345 6 and and CC cord-276616-odmnvv7m 345 7 Wilson Wilson NNP cord-276616-odmnvv7m 345 8 's 's POS cord-276616-odmnvv7m 345 9 diseases disease NNS cord-276616-odmnvv7m 345 10 are be VBP cord-276616-odmnvv7m 345 11 given give VBN cord-276616-odmnvv7m 345 12 in in IN cord-276616-odmnvv7m 345 13 the the DT cord-276616-odmnvv7m 345 14 paper paper NN cord-276616-odmnvv7m 345 15 by by IN cord-276616-odmnvv7m 345 16 4 4 CD cord-276616-odmnvv7m 345 17 . . . cord-276616-odmnvv7m 346 1 To to TO cord-276616-odmnvv7m 346 2 study study VB cord-276616-odmnvv7m 346 3 the the DT cord-276616-odmnvv7m 346 4 possibility possibility NN cord-276616-odmnvv7m 346 5 that that IN cord-276616-odmnvv7m 346 6 these these DT cord-276616-odmnvv7m 346 7 characteristic characteristic JJ cord-276616-odmnvv7m 346 8 vacuoles vacuole NNS cord-276616-odmnvv7m 346 9 are be VBP cord-276616-odmnvv7m 346 10 due due JJ cord-276616-odmnvv7m 346 11 to to IN cord-276616-odmnvv7m 346 12 oxygen oxygen NN cord-276616-odmnvv7m 346 13 would would MD cord-276616-odmnvv7m 346 14 mean mean VB cord-276616-odmnvv7m 346 15 the the DT cord-276616-odmnvv7m 346 16 application application NN cord-276616-odmnvv7m 346 17 of of IN cord-276616-odmnvv7m 346 18 a a DT cord-276616-odmnvv7m 346 19 variety variety NN cord-276616-odmnvv7m 346 20 of of IN cord-276616-odmnvv7m 346 21 biochemical biochemical JJ cord-276616-odmnvv7m 346 22 and and CC cord-276616-odmnvv7m 346 23 histochemical histochemical JJ cord-276616-odmnvv7m 346 24 techniques technique NNS cord-276616-odmnvv7m 346 25 , , , cord-276616-odmnvv7m 346 26 including include VBG cord-276616-odmnvv7m 346 27 a a DT cord-276616-odmnvv7m 346 28 qualitative qualitative JJ cord-276616-odmnvv7m 346 29 and and CC cord-276616-odmnvv7m 346 30 quantitative quantitative JJ cord-276616-odmnvv7m 346 31 study study NN cord-276616-odmnvv7m 346 32 of of IN cord-276616-odmnvv7m 346 33 the the DT cord-276616-odmnvv7m 346 34 enzymes enzyme NNS cord-276616-odmnvv7m 346 35 just just RB cord-276616-odmnvv7m 346 36 mentioned mention VBD cord-276616-odmnvv7m 346 37 ( ( -LRB- cord-276616-odmnvv7m 346 38 Brunori Brunori NNP cord-276616-odmnvv7m 346 39 and and CC cord-276616-odmnvv7m 346 40 Rotilio Rotilio NNP cord-276616-odmnvv7m 346 41 , , , cord-276616-odmnvv7m 346 42 1984 1984 CD cord-276616-odmnvv7m 346 43 ) ) -RRB- cord-276616-odmnvv7m 346 44 . . . cord-276616-odmnvv7m 347 1 R.M. R.M. NNP cord-276616-odmnvv7m 347 2 Barlow Barlow NNP cord-276616-odmnvv7m 347 3 ( ( -LRB- cord-276616-odmnvv7m 347 4 personal personal JJ cord-276616-odmnvv7m 347 5 communication communication NN cord-276616-odmnvv7m 347 6 , , , cord-276616-odmnvv7m 347 7 1994 1994 CD cord-276616-odmnvv7m 347 8 ) ) -RRB- cord-276616-odmnvv7m 347 9 has have VBZ cord-276616-odmnvv7m 347 10 suggested suggest VBN cord-276616-odmnvv7m 347 11 that that IN cord-276616-odmnvv7m 347 12 marginal marginal JJ cord-276616-odmnvv7m 347 13 copper copper NN cord-276616-odmnvv7m 347 14 deficiency deficiency NN cord-276616-odmnvv7m 347 15 , , , cord-276616-odmnvv7m 347 16 which which WDT cord-276616-odmnvv7m 347 17 is be VBZ cord-276616-odmnvv7m 347 18 very very RB cord-276616-odmnvv7m 347 19 common common JJ cord-276616-odmnvv7m 347 20 in in IN cord-276616-odmnvv7m 347 21 sheep sheep NN cord-276616-odmnvv7m 347 22 , , , cord-276616-odmnvv7m 347 23 would would MD cord-276616-odmnvv7m 347 24 affect affect VB cord-276616-odmnvv7m 347 25 the the DT cord-276616-odmnvv7m 347 26 superoxide superoxide NN cord-276616-odmnvv7m 347 27 dismutases dismutase NNS cord-276616-odmnvv7m 347 28 and and CC cord-276616-odmnvv7m 347 29 facilitate facilitate VBP cord-276616-odmnvv7m 347 30 accumulations accumulation NNS cord-276616-odmnvv7m 347 31 of of IN cord-276616-odmnvv7m 347 32 oxygen oxygen NN cord-276616-odmnvv7m 347 33 free free JJ cord-276616-odmnvv7m 347 34 radicals radical NNS cord-276616-odmnvv7m 347 35 and and CC cord-276616-odmnvv7m 347 36 toxic toxic JJ cord-276616-odmnvv7m 347 37 peroxides peroxide NNS cord-276616-odmnvv7m 347 38 , , , cord-276616-odmnvv7m 347 39 but but CC cord-276616-odmnvv7m 347 40 the the DT cord-276616-odmnvv7m 347 41 result result NN cord-276616-odmnvv7m 347 42 from from IN cord-276616-odmnvv7m 347 43 studies study NNS cord-276616-odmnvv7m 347 44 on on IN cord-276616-odmnvv7m 347 45 copper copper NN cord-276616-odmnvv7m 347 46 levels level NNS cord-276616-odmnvv7m 347 47 in in IN cord-276616-odmnvv7m 347 48 the the DT cord-276616-odmnvv7m 347 49 brains brain NNS cord-276616-odmnvv7m 347 50 of of IN cord-276616-odmnvv7m 347 51 sheep sheep NN cord-276616-odmnvv7m 347 52 with with IN cord-276616-odmnvv7m 347 53 scrapie scrapie NN cord-276616-odmnvv7m 347 54 and and CC cord-276616-odmnvv7m 347 55 those those DT cord-276616-odmnvv7m 347 56 of of IN cord-276616-odmnvv7m 347 57 normal normal JJ cord-276616-odmnvv7m 347 58 sheep sheep NNS cord-276616-odmnvv7m 347 59 do do VBP cord-276616-odmnvv7m 347 60 not not RB cord-276616-odmnvv7m 347 61 support support VB cord-276616-odmnvv7m 347 62 this this DT cord-276616-odmnvv7m 347 63 idea idea NN cord-276616-odmnvv7m 347 64 . . . cord-276616-odmnvv7m 348 1 MCF MCF NNP cord-276616-odmnvv7m 348 2 murine murine JJ cord-276616-odmnvv7m 348 3 viruses virus NNS cord-276616-odmnvv7m 348 4 are be VBP cord-276616-odmnvv7m 348 5 formed form VBN cord-276616-odmnvv7m 348 6 de de FW cord-276616-odmnvv7m 348 7 novo novo NNP cord-276616-odmnvv7m 348 8 by by IN cord-276616-odmnvv7m 348 9 recombination recombination NN cord-276616-odmnvv7m 348 10 between between IN cord-276616-odmnvv7m 348 11 exogenous exogenous JJ cord-276616-odmnvv7m 348 12 , , , cord-276616-odmnvv7m 348 13 infectious infectious JJ cord-276616-odmnvv7m 348 14 ecotropic ecotropic JJ cord-276616-odmnvv7m 348 15 virus virus NN cord-276616-odmnvv7m 348 16 and and CC cord-276616-odmnvv7m 348 17 endogenous endogenous JJ cord-276616-odmnvv7m 348 18 sequences sequence NNS cord-276616-odmnvv7m 348 19 related relate VBN cord-276616-odmnvv7m 348 20 to to IN cord-276616-odmnvv7m 348 21 xenotropic xenotropic NNP cord-276616-odmnvv7m 348 22 virus virus NN cord-276616-odmnvv7m 348 23 . . . cord-276616-odmnvv7m 349 1 Members member NNS cord-276616-odmnvv7m 349 2 of of IN cord-276616-odmnvv7m 349 3 this this DT cord-276616-odmnvv7m 349 4 group group NN cord-276616-odmnvv7m 349 5 of of IN cord-276616-odmnvv7m 349 6 viruses virus NNS cord-276616-odmnvv7m 349 7 have have VBP cord-276616-odmnvv7m 349 8 been be VBN cord-276616-odmnvv7m 349 9 isolated isolate VBN cord-276616-odmnvv7m 349 10 from from IN cord-276616-odmnvv7m 349 11 spontaneous spontaneous JJ cord-276616-odmnvv7m 349 12 mouse mouse NN cord-276616-odmnvv7m 349 13 lymphomas lymphoma NNS cord-276616-odmnvv7m 349 14 and and CC cord-276616-odmnvv7m 349 15 can can MD cord-276616-odmnvv7m 349 16 infect infect VB cord-276616-odmnvv7m 349 17 both both DT cord-276616-odmnvv7m 349 18 murine murine JJ cord-276616-odmnvv7m 349 19 and and CC cord-276616-odmnvv7m 349 20 xenogenic xenogenic JJ cord-276616-odmnvv7m 349 21 cells cell NNS cord-276616-odmnvv7m 349 22 ( ( -LRB- cord-276616-odmnvv7m 349 23 cells cell NNS cord-276616-odmnvv7m 349 24 of of IN cord-276616-odmnvv7m 349 25 other other JJ cord-276616-odmnvv7m 349 26 species specie NNS cord-276616-odmnvv7m 349 27 ) ) -RRB- cord-276616-odmnvv7m 349 28 . . . cord-276616-odmnvv7m 350 1 Special special JJ cord-276616-odmnvv7m 350 2 attention attention NN cord-276616-odmnvv7m 350 3 is be VBZ cord-276616-odmnvv7m 350 4 drawn draw VBN cord-276616-odmnvv7m 350 5 to to IN cord-276616-odmnvv7m 350 6 work work NN cord-276616-odmnvv7m 350 7 of of IN cord-276616-odmnvv7m 350 8 Gardner Gardner NNP cord-276616-odmnvv7m 350 9 and and CC cord-276616-odmnvv7m 350 10 colleagues colleague NNS cord-276616-odmnvv7m 350 11 ( ( -LRB- cord-276616-odmnvv7m 350 12 1979 1979 CD cord-276616-odmnvv7m 350 13 ) ) -RRB- cord-276616-odmnvv7m 350 14 on on IN cord-276616-odmnvv7m 350 15 a a DT cord-276616-odmnvv7m 350 16 routine routine JJ cord-276616-odmnvv7m 350 17 retrovirus retrovirus NN cord-276616-odmnvv7m 350 18 motor motor NN cord-276616-odmnvv7m 350 19 disease disease NN cord-276616-odmnvv7m 350 20 . . . cord-276616-odmnvv7m 351 1 MCF MCF NNP cord-276616-odmnvv7m 351 2 - - HYPH cord-276616-odmnvv7m 351 3 like like JJ cord-276616-odmnvv7m 351 4 viruses virus NNS cord-276616-odmnvv7m 351 5 have have VBP cord-276616-odmnvv7m 351 6 also also RB cord-276616-odmnvv7m 351 7 been be VBN cord-276616-odmnvv7m 351 8 recovered recover VBN cord-276616-odmnvv7m 351 9 from from IN cord-276616-odmnvv7m 351 10 feline feline JJ cord-276616-odmnvv7m 351 11 ( ( -LRB- cord-276616-odmnvv7m 351 12 Neil Neil NNP cord-276616-odmnvv7m 351 13 et et NNP cord-276616-odmnvv7m 351 14 aL aL NNP cord-276616-odmnvv7m 351 15 , , , cord-276616-odmnvv7m 351 16 1991 1991 CD cord-276616-odmnvv7m 351 17 ) ) -RRB- cord-276616-odmnvv7m 351 18 and and CC cord-276616-odmnvv7m 351 19 avian avian JJ cord-276616-odmnvv7m 351 20 oncogene oncogene NN cord-276616-odmnvv7m 351 21 - - HYPH cord-276616-odmnvv7m 351 22 murine murine JJ cord-276616-odmnvv7m 351 23 chimeric chimeric JJ cord-276616-odmnvv7m 351 24 systems system NNS cord-276616-odmnvv7m 352 1 ( ( -LRB- cord-276616-odmnvv7m 352 2 Feuer Feuer NNP cord-276616-odmnvv7m 352 3 et et NNP cord-276616-odmnvv7m 352 4 aL aL NNP cord-276616-odmnvv7m 352 5 , , , cord-276616-odmnvv7m 352 6 i993 i993 NNP cord-276616-odmnvv7m 352 7 ) ) -RRB- cord-276616-odmnvv7m 352 8 . . . cord-276616-odmnvv7m 353 1 Other other JJ cord-276616-odmnvv7m 353 2 references reference NNS cord-276616-odmnvv7m 353 3 that that WDT cord-276616-odmnvv7m 353 4 provide provide VBP cord-276616-odmnvv7m 353 5 a a DT cord-276616-odmnvv7m 353 6 useful useful JJ cord-276616-odmnvv7m 353 7 entry entry NN cord-276616-odmnvv7m 353 8 to to IN cord-276616-odmnvv7m 353 9 this this DT cord-276616-odmnvv7m 353 10 field field NN cord-276616-odmnvv7m 353 11 include include VBP cord-276616-odmnvv7m 353 12 Adachi Adachi NNP cord-276616-odmnvv7m 353 13 et et NNP cord-276616-odmnvv7m 353 14 al al NNP cord-276616-odmnvv7m 353 15 . . . cord-276616-odmnvv7m 354 1 ( ( -LRB- cord-276616-odmnvv7m 354 2 1984 1984 CD cord-276616-odmnvv7m 354 3 ) ) -RRB- cord-276616-odmnvv7m 354 4 , , , cord-276616-odmnvv7m 354 5 Chattopadhyay Chattopadhyay NNP cord-276616-odmnvv7m 354 6 et et FW cord-276616-odmnvv7m 354 7 aL aL NNP cord-276616-odmnvv7m 354 8 ( ( -LRB- cord-276616-odmnvv7m 354 9 1991 1991 CD cord-276616-odmnvv7m 354 10 ) ) -RRB- cord-276616-odmnvv7m 354 11 , , , cord-276616-odmnvv7m 354 12 Di Di NNP cord-276616-odmnvv7m 354 13 Fronzo Fronzo NNP cord-276616-odmnvv7m 354 14 and and CC cord-276616-odmnvv7m 354 15 Holland Holland NNP cord-276616-odmnvv7m 354 16 ( ( -LRB- cord-276616-odmnvv7m 354 17 1993 1993 CD cord-276616-odmnvv7m 354 18 ) ) -RRB- cord-276616-odmnvv7m 354 19 , , , cord-276616-odmnvv7m 354 20 Khan Khan NNP cord-276616-odmnvv7m 354 21 et et NNP cord-276616-odmnvv7m 354 22 aL aL NNP cord-276616-odmnvv7m 354 23 ( ( -LRB- cord-276616-odmnvv7m 354 24 1987 1987 CD cord-276616-odmnvv7m 354 25 ) ) -RRB- cord-276616-odmnvv7m 355 1 , , , cord-276616-odmnvv7m 355 2 Koch Koch NNP cord-276616-odmnvv7m 355 3 et et NNP cord-276616-odmnvv7m 355 4 aL aL NNP cord-276616-odmnvv7m 355 5 ( ( -LRB- cord-276616-odmnvv7m 355 6 1984 1984 CD cord-276616-odmnvv7m 355 7 ) ) -RRB- cord-276616-odmnvv7m 355 8 , , , cord-276616-odmnvv7m 355 9 Levy Levy NNP cord-276616-odmnvv7m 355 10 et et NNP cord-276616-odmnvv7m 355 11 al al NNP cord-276616-odmnvv7m 355 12 . . . cord-276616-odmnvv7m 356 1 ( ( -LRB- cord-276616-odmnvv7m 356 2 1985 1985 CD cord-276616-odmnvv7m 356 3 ) ) -RRB- cord-276616-odmnvv7m 356 4 , , , cord-276616-odmnvv7m 356 5 Makino Makino NNP cord-276616-odmnvv7m 356 6 et et NNP cord-276616-odmnvv7m 356 7 al al NNP cord-276616-odmnvv7m 356 8 . . . cord-276616-odmnvv7m 357 1 ( ( -LRB- cord-276616-odmnvv7m 357 2 1990 1990 CD cord-276616-odmnvv7m 357 3 ) ) -RRB- cord-276616-odmnvv7m 357 4 , , , cord-276616-odmnvv7m 357 5 Oliff Oliff NNP cord-276616-odmnvv7m 357 6 et et NNP cord-276616-odmnvv7m 357 7 al al NNP cord-276616-odmnvv7m 357 8 . . . cord-276616-odmnvv7m 358 1 ( ( -LRB- cord-276616-odmnvv7m 358 2 1984 1984 CD cord-276616-odmnvv7m 358 3 ) ) -RRB- cord-276616-odmnvv7m 358 4 , , , cord-276616-odmnvv7m 358 5 Quint Quint NNP cord-276616-odmnvv7m 358 6 et et NNP cord-276616-odmnvv7m 358 7 al al NNP cord-276616-odmnvv7m 358 8 . . . cord-276616-odmnvv7m 359 1 ( ( -LRB- cord-276616-odmnvv7m 359 2 1984 1984 CD cord-276616-odmnvv7m 359 3 ) ) -RRB- cord-276616-odmnvv7m 359 4 and and CC cord-276616-odmnvv7m 359 5 Shields Shields NNP cord-276616-odmnvv7m 359 6 et et NNP cord-276616-odmnvv7m 359 7 al al NNP cord-276616-odmnvv7m 359 8 . . . cord-276616-odmnvv7m 360 1 ( ( -LRB- cord-276616-odmnvv7m 360 2 1991 1991 CD cord-276616-odmnvv7m 360 3 ) ) -RRB- cord-276616-odmnvv7m 360 4 . . . cord-276616-odmnvv7m 361 1 6 6 LS cord-276616-odmnvv7m 361 2 . . . cord-276616-odmnvv7m 362 1 If if IN cord-276616-odmnvv7m 362 2 scrapie scrapie NN cord-276616-odmnvv7m 362 3 - - HYPH cord-276616-odmnvv7m 362 4 infected infect VBN cord-276616-odmnvv7m 362 5 brain brain NN cord-276616-odmnvv7m 362 6 had have VBD cord-276616-odmnvv7m 362 7 been be VBN cord-276616-odmnvv7m 362 8 used use VBN cord-276616-odmnvv7m 362 9 instead instead RB cord-276616-odmnvv7m 362 10 of of IN cord-276616-odmnvv7m 362 11 normal normal JJ cord-276616-odmnvv7m 362 12 brain brain NN cord-276616-odmnvv7m 362 13 and and CC cord-276616-odmnvv7m 362 14 loss loss NN cord-276616-odmnvv7m 362 15 of of IN cord-276616-odmnvv7m 362 16 activity activity NN cord-276616-odmnvv7m 362 17 of of IN cord-276616-odmnvv7m 362 18 the the DT cord-276616-odmnvv7m 362 19 scrapie scrapie NN cord-276616-odmnvv7m 362 20 agent agent NN cord-276616-odmnvv7m 362 21 had have VBD cord-276616-odmnvv7m 362 22 been be VBN cord-276616-odmnvv7m 362 23 observed observe VBN cord-276616-odmnvv7m 362 24 , , , cord-276616-odmnvv7m 362 25 then then RB cord-276616-odmnvv7m 362 26 the the DT cord-276616-odmnvv7m 362 27 effect effect NN cord-276616-odmnvv7m 362 28 would would MD cord-276616-odmnvv7m 362 29 probably probably RB cord-276616-odmnvv7m 362 30 have have VB cord-276616-odmnvv7m 362 31 been be VBN cord-276616-odmnvv7m 362 32 due due JJ cord-276616-odmnvv7m 362 33 to to IN cord-276616-odmnvv7m 362 34 non non JJ cord-276616-odmnvv7m 362 35 - - JJ cord-276616-odmnvv7m 362 36 proteolytic proteolytic JJ cord-276616-odmnvv7m 362 37 factors factor NNS cord-276616-odmnvv7m 362 38 in in IN cord-276616-odmnvv7m 362 39 the the DT cord-276616-odmnvv7m 362 40 Pronase Pronase NNP cord-276616-odmnvv7m 362 41 . . . cord-276616-odmnvv7m 363 1 The the DT cord-276616-odmnvv7m 363 2 suggestion suggestion NN cord-276616-odmnvv7m 363 3 was be VBD cord-276616-odmnvv7m 363 4 offered offer VBN cord-276616-odmnvv7m 363 5 ( ( -LRB- cord-276616-odmnvv7m 363 6 Darcel Darcel NNP cord-276616-odmnvv7m 363 7 , , , cord-276616-odmnvv7m 363 8 1990 1990 CD cord-276616-odmnvv7m 363 9 ) ) -RRB- cord-276616-odmnvv7m 363 10 that that IN cord-276616-odmnvv7m 363 11 the the DT cord-276616-odmnvv7m 363 12 brain brain NN cord-276616-odmnvv7m 363 13 extracts extract NNS cord-276616-odmnvv7m 363 14 contained contain VBD cord-276616-odmnvv7m 363 15 a a DT cord-276616-odmnvv7m 363 16 proteinase proteinase NN cord-276616-odmnvv7m 363 17 inhibitor inhibitor NN cord-276616-odmnvv7m 363 18 . . . cord-276616-odmnvv7m 364 1 This this DT cord-276616-odmnvv7m 364 2 should should MD cord-276616-odmnvv7m 364 3 be be VB cord-276616-odmnvv7m 364 4 looked look VBN cord-276616-odmnvv7m 364 5 for for IN cord-276616-odmnvv7m 364 6 , , , cord-276616-odmnvv7m 364 7 and and CC cord-276616-odmnvv7m 364 8 , , , cord-276616-odmnvv7m 364 9 if if IN cord-276616-odmnvv7m 364 10 found find VBN cord-276616-odmnvv7m 364 11 , , , cord-276616-odmnvv7m 364 12 removed remove VBN cord-276616-odmnvv7m 364 13 from from IN cord-276616-odmnvv7m 364 14 the the DT cord-276616-odmnvv7m 364 15 system system NN cord-276616-odmnvv7m 364 16 before before IN cord-276616-odmnvv7m 364 17 applying apply VBG cord-276616-odmnvv7m 364 18 the the DT cord-276616-odmnvv7m 364 19 proteinase proteinase NN cord-276616-odmnvv7m 364 20 treatment treatment NN cord-276616-odmnvv7m 364 21 . . . cord-276616-odmnvv7m 365 1 These these DT cord-276616-odmnvv7m 365 2 authors author NNS cord-276616-odmnvv7m 365 3 ' ' POS cord-276616-odmnvv7m 365 4 protocols protocol NNS cord-276616-odmnvv7m 365 5 show show VBP cord-276616-odmnvv7m 365 6 that that IN cord-276616-odmnvv7m 365 7 brain brain NN cord-276616-odmnvv7m 365 8 homogenates homogenate NNS cord-276616-odmnvv7m 365 9 were be VBD cord-276616-odmnvv7m 365 10 homogenized homogenize VBN cord-276616-odmnvv7m 365 11 with with IN cord-276616-odmnvv7m 365 12 a a DT cord-276616-odmnvv7m 365 13 solution solution NN cord-276616-odmnvv7m 365 14 containing contain VBG cord-276616-odmnvv7m 365 15 proteinase proteinase NN cord-276616-odmnvv7m 365 16 - - HYPH cord-276616-odmnvv7m 365 17 K k NN cord-276616-odmnvv7m 365 18 , , , cord-276616-odmnvv7m 365 19 and and CC cord-276616-odmnvv7m 365 20 the the DT cord-276616-odmnvv7m 365 21 supernatant supernatant NN cord-276616-odmnvv7m 365 22 resulting result VBG cord-276616-odmnvv7m 365 23 from from IN cord-276616-odmnvv7m 365 24 centrifugation centrifugation NN cord-276616-odmnvv7m 365 25 was be VBD cord-276616-odmnvv7m 365 26 incubated incubate VBN cord-276616-odmnvv7m 365 27 for for IN cord-276616-odmnvv7m 365 28 I -PRON- PRP cord-276616-odmnvv7m 365 29 hour hour NN cord-276616-odmnvv7m 365 30 . . . cord-276616-odmnvv7m 366 1 The the DT cord-276616-odmnvv7m 366 2 action action NN cord-276616-odmnvv7m 366 3 of of IN cord-276616-odmnvv7m 366 4 the the DT cord-276616-odmnvv7m 366 5 enzyme enzyme NN cord-276616-odmnvv7m 366 6 was be VBD cord-276616-odmnvv7m 366 7 then then RB cord-276616-odmnvv7m 366 8 blocked block VBN cord-276616-odmnvv7m 366 9 and and CC cord-276616-odmnvv7m 366 10 the the DT cord-276616-odmnvv7m 366 11 solution solution NN cord-276616-odmnvv7m 366 12 was be VBD cord-276616-odmnvv7m 366 13 then then RB cord-276616-odmnvv7m 366 14 treated treat VBN cord-276616-odmnvv7m 366 15 with with IN cord-276616-odmnvv7m 366 16 micrococcal micrococcal NNP cord-276616-odmnvv7m 366 17 nuclease nuclease NNP cord-276616-odmnvv7m 366 18 . . . cord-276616-odmnvv7m 367 1 Many many JJ cord-276616-odmnvv7m 367 2 other other JJ cord-276616-odmnvv7m 367 3 steps step NNS cord-276616-odmnvv7m 367 4 followed follow VBN cord-276616-odmnvv7m 367 5 before before IN cord-276616-odmnvv7m 367 6 titres titre NNS cord-276616-odmnvv7m 367 7 were be VBD cord-276616-odmnvv7m 367 8 determined determine VBN cord-276616-odmnvv7m 367 9 in in IN cord-276616-odmnvv7m 367 10 mice mouse NNS cord-276616-odmnvv7m 367 11 and and CC cord-276616-odmnvv7m 367 12 hamsters hamster NNS cord-276616-odmnvv7m 367 13 and and CC cord-276616-odmnvv7m 367 14 compared compare VBN cord-276616-odmnvv7m 367 15 with with IN cord-276616-odmnvv7m 367 16 those those DT cord-276616-odmnvv7m 367 17 in in IN cord-276616-odmnvv7m 367 18 the the DT cord-276616-odmnvv7m 367 19 original original JJ cord-276616-odmnvv7m 367 20 homogenates homogenate NNS cord-276616-odmnvv7m 367 21 . . . cord-276616-odmnvv7m 368 1 The the DT cord-276616-odmnvv7m 368 2 name name NN cord-276616-odmnvv7m 368 3 ' ' `` cord-276616-odmnvv7m 368 4 Berry Berry NNP cord-276616-odmnvv7m 368 5 - - HYPH cord-276616-odmnvv7m 368 6 Dedrick Dedrick NNP cord-276616-odmnvv7m 368 7 phenomenon phenomenon NN cord-276616-odmnvv7m 368 8 ' ' '' cord-276616-odmnvv7m 368 9 was be VBD cord-276616-odmnvv7m 368 10 coined coin VBN cord-276616-odmnvv7m 368 11 to to TO cord-276616-odmnvv7m 368 12 describe describe VB cord-276616-odmnvv7m 368 13 the the DT cord-276616-odmnvv7m 368 14 results result NNS cord-276616-odmnvv7m 368 15 that that WDT cord-276616-odmnvv7m 368 16 followed follow VBD cord-276616-odmnvv7m 368 17 the the DT cord-276616-odmnvv7m 368 18 appearance appearance NN cord-276616-odmnvv7m 368 19 of of IN cord-276616-odmnvv7m 368 20 myxomatosis myxomatosis NN cord-276616-odmnvv7m 368 21 after after IN cord-276616-odmnvv7m 368 22 inoculation inoculation NN cord-276616-odmnvv7m 368 23 of of IN cord-276616-odmnvv7m 368 24 rabbits rabbit NNS cord-276616-odmnvv7m 368 25 with with IN cord-276616-odmnvv7m 368 26 a a DT cord-276616-odmnvv7m 368 27 heat heat NN cord-276616-odmnvv7m 368 28 - - HYPH cord-276616-odmnvv7m 368 29 inactivated inactivate VBN cord-276616-odmnvv7m 368 30 preparation preparation NN cord-276616-odmnvv7m 368 31 of of IN cord-276616-odmnvv7m 368 32 myxoma myxoma NNP cord-276616-odmnvv7m 368 33 virus virus NN cord-276616-odmnvv7m 368 34 inoculated inoculate VBN cord-276616-odmnvv7m 368 35 into into IN cord-276616-odmnvv7m 368 36 rabbits rabbit NNS cord-276616-odmnvv7m 368 37 together together RB cord-276616-odmnvv7m 368 38 with with IN cord-276616-odmnvv7m 368 39 live live JJ cord-276616-odmnvv7m 368 40 fibroma fibroma NN cord-276616-odmnvv7m 368 41 virus virus NN cord-276616-odmnvv7m 368 42 . . . cord-276616-odmnvv7m 369 1 This this DT cord-276616-odmnvv7m 369 2 was be VBD cord-276616-odmnvv7m 369 3 later later RB cord-276616-odmnvv7m 369 4 explained explain VBN cord-276616-odmnvv7m 369 5 as as IN cord-276616-odmnvv7m 369 6 resulting result VBG cord-276616-odmnvv7m 369 7 from from IN cord-276616-odmnvv7m 369 8 the the DT cord-276616-odmnvv7m 369 9 presence presence NN cord-276616-odmnvv7m 369 10 of of IN cord-276616-odmnvv7m 369 11 live live JJ cord-276616-odmnvv7m 369 12 , , , cord-276616-odmnvv7m 369 13 residual residual JJ cord-276616-odmnvv7m 369 14 myxomatosis myxomatosis NN cord-276616-odmnvv7m 369 15 virus virus NN cord-276616-odmnvv7m 369 16 ( ( -LRB- cord-276616-odmnvv7m 369 17 Fenner Fenner NNP cord-276616-odmnvv7m 369 18 et et NNP cord-276616-odmnvv7m 369 19 al al NNP cord-276616-odmnvv7m 369 20 . . NNP cord-276616-odmnvv7m 369 21 , , , cord-276616-odmnvv7m 369 22 1974 1974 CD cord-276616-odmnvv7m 369 23 ) ) -RRB- cord-276616-odmnvv7m 369 24 . . . cord-276616-odmnvv7m 370 1 However however RB cord-276616-odmnvv7m 370 2 , , , cord-276616-odmnvv7m 370 3 cross cross JJ cord-276616-odmnvv7m 370 4 - - JJ cord-276616-odmnvv7m 370 5 reactivation reactivation NN cord-276616-odmnvv7m 370 6 is be VBZ cord-276616-odmnvv7m 370 7 a a DT cord-276616-odmnvv7m 370 8 known know VBN cord-276616-odmnvv7m 370 9 phenomenon phenomenon NN cord-276616-odmnvv7m 370 10 by by IN cord-276616-odmnvv7m 370 11 which which WDT cord-276616-odmnvv7m 370 12 infectious infectious JJ cord-276616-odmnvv7m 370 13 virions virion NNS cord-276616-odmnvv7m 370 14 containing contain VBG cord-276616-odmnvv7m 370 15 active active JJ cord-276616-odmnvv7m 370 16 genes gene NNS cord-276616-odmnvv7m 370 17 from from IN cord-276616-odmnvv7m 370 18 both both DT cord-276616-odmnvv7m 370 19 viruses virus NNS cord-276616-odmnvv7m 370 20 can can MD cord-276616-odmnvv7m 370 21 result result VB cord-276616-odmnvv7m 370 22 from from IN cord-276616-odmnvv7m 370 23 genetic genetic JJ cord-276616-odmnvv7m 370 24 recombination recombination NN cord-276616-odmnvv7m 370 25 between between IN cord-276616-odmnvv7m 370 26 an an DT cord-276616-odmnvv7m 370 27 infectious infectious JJ cord-276616-odmnvv7m 370 28 virus virus NN cord-276616-odmnvv7m 370 29 and and CC cord-276616-odmnvv7m 370 30 a a DT cord-276616-odmnvv7m 370 31 related related JJ cord-276616-odmnvv7m 370 32 inactivated inactivate VBN cord-276616-odmnvv7m 370 33 virus virus NN cord-276616-odmnvv7m 370 34 ( ( -LRB- cord-276616-odmnvv7m 370 35 Fenner Fenner NNP cord-276616-odmnvv7m 370 36 et et NNP cord-276616-odmnvv7m 370 37 al al NNP cord-276616-odmnvv7m 370 38 . . NNP cord-276616-odmnvv7m 370 39 , , , cord-276616-odmnvv7m 370 40 1987 1987 CD cord-276616-odmnvv7m 370 41 ) ) -RRB- cord-276616-odmnvv7m 371 1 My -PRON- PRP$ cord-276616-odmnvv7m 371 2 late late JJ cord-276616-odmnvv7m 371 3 colleague colleague NN cord-276616-odmnvv7m 371 4 Robert Robert NNP cord-276616-odmnvv7m 371 5 Kasting Kasting NNP cord-276616-odmnvv7m 371 6 became become VBD cord-276616-odmnvv7m 371 7 ill ill RB cord-276616-odmnvv7m 371 8 some some DT cord-276616-odmnvv7m 371 9 years year NNS cord-276616-odmnvv7m 371 10 after after IN cord-276616-odmnvv7m 371 11 we -PRON- PRP cord-276616-odmnvv7m 371 12 concluded conclude VBD cord-276616-odmnvv7m 371 13 our -PRON- PRP$ cord-276616-odmnvv7m 371 14 studies study NNS cord-276616-odmnvv7m 371 15 of of IN cord-276616-odmnvv7m 371 16 amino amino JJ cord-276616-odmnvv7m 371 17 acids acid NNS cord-276616-odmnvv7m 371 18 in in IN cord-276616-odmnvv7m 371 19 scrapie scrapie NN cord-276616-odmnvv7m 371 20 and and CC cord-276616-odmnvv7m 371 21 normal normal JJ cord-276616-odmnvv7m 371 22 brain brain NN cord-276616-odmnvv7m 371 23 . . . cord-276616-odmnvv7m 372 1 He -PRON- PRP cord-276616-odmnvv7m 372 2 felt feel VBD cord-276616-odmnvv7m 372 3 that that IN cord-276616-odmnvv7m 372 4 the the DT cord-276616-odmnvv7m 372 5 signs sign NNS cord-276616-odmnvv7m 372 6 of of IN cord-276616-odmnvv7m 372 7 neurological neurological JJ cord-276616-odmnvv7m 372 8 disease disease NN cord-276616-odmnvv7m 372 9 that that WDT cord-276616-odmnvv7m 372 10 he -PRON- PRP cord-276616-odmnvv7m 372 11 exhibited exhibit VBD cord-276616-odmnvv7m 372 12 meant mean VBD cord-276616-odmnvv7m 372 13 he -PRON- PRP cord-276616-odmnvv7m 372 14 had have VBD cord-276616-odmnvv7m 372 15 acquired acquire VBN cord-276616-odmnvv7m 372 16 scrapie scrapie NN cord-276616-odmnvv7m 372 17 from from IN cord-276616-odmnvv7m 372 18 aerosols aerosol NNS cord-276616-odmnvv7m 372 19 produced produce VBN cord-276616-odmnvv7m 372 20 by by IN cord-276616-odmnvv7m 372 21 grinding grind VBG cord-276616-odmnvv7m 372 22 the the DT cord-276616-odmnvv7m 372 23 brains brain NNS cord-276616-odmnvv7m 372 24 . . . cord-276616-odmnvv7m 373 1 His -PRON- PRP$ cord-276616-odmnvv7m 373 2 brain brain NN cord-276616-odmnvv7m 373 3 was be VBD cord-276616-odmnvv7m 373 4 sent send VBN cord-276616-odmnvv7m 373 5 to to IN cord-276616-odmnvv7m 373 6 the the DT cord-276616-odmnvv7m 373 7 Rocky Rocky NNP cord-276616-odmnvv7m 373 8 Mountain Mountain NNP cord-276616-odmnvv7m 373 9 Laboratory Laboratory NNP cord-276616-odmnvv7m 373 10 after after IN cord-276616-odmnvv7m 373 11 his -PRON- PRP$ cord-276616-odmnvv7m 373 12 death death NN cord-276616-odmnvv7m 373 13 for for IN cord-276616-odmnvv7m 373 14 detailed detailed JJ cord-276616-odmnvv7m 373 15 histology histology NN cord-276616-odmnvv7m 373 16 and and CC cord-276616-odmnvv7m 373 17 for for IN cord-276616-odmnvv7m 373 18 transmission transmission NN cord-276616-odmnvv7m 373 19 experiments experiment NNS cord-276616-odmnvv7m 373 20 . . . cord-276616-odmnvv7m 374 1 The the DT cord-276616-odmnvv7m 374 2 results result NNS cord-276616-odmnvv7m 374 3 did do VBD cord-276616-odmnvv7m 374 4 not not RB cord-276616-odmnvv7m 374 5 confirm confirm VB cord-276616-odmnvv7m 374 6 his -PRON- PRP$ cord-276616-odmnvv7m 374 7 suspicions suspicion NNS cord-276616-odmnvv7m 374 8 . . . cord-276616-odmnvv7m 375 1 i0 i0 NNP cord-276616-odmnvv7m 375 2 . . . cord-276616-odmnvv7m 376 1 Six six CD cord-276616-odmnvv7m 376 2 of of IN cord-276616-odmnvv7m 376 3 the the DT cord-276616-odmnvv7m 376 4 26 26 CD cord-276616-odmnvv7m 376 5 lambs lamb NNS cord-276616-odmnvv7m 376 6 born bear VBN cord-276616-odmnvv7m 376 7 to to IN cord-276616-odmnvv7m 376 8 recipients recipient NNS cord-276616-odmnvv7m 376 9 of of IN cord-276616-odmnvv7m 376 10 embryos embryo NNS cord-276616-odmnvv7m 376 11 transplanted transplant VBN cord-276616-odmnvv7m 376 12 from from IN cord-276616-odmnvv7m 376 13 donor donor NN cord-276616-odmnvv7m 376 14 ewes ewe NNS cord-276616-odmnvv7m 376 15 that that WDT cord-276616-odmnvv7m 376 16 had have VBD cord-276616-odmnvv7m 376 17 been be VBN cord-276616-odmnvv7m 376 18 experimentally experimentally RB cord-276616-odmnvv7m 376 19 infected infect VBN cord-276616-odmnvv7m 376 20 with with IN cord-276616-odmnvv7m 376 21 scrapie scrapie NN cord-276616-odmnvv7m 376 22 developed develop VBD cord-276616-odmnvv7m 376 23 this this DT cord-276616-odmnvv7m 376 24 disease disease NN cord-276616-odmnvv7m 376 25 ( ( -LRB- cord-276616-odmnvv7m 376 26 Foster Foster NNP cord-276616-odmnvv7m 376 27 et et NNP cord-276616-odmnvv7m 376 28 al al NNP cord-276616-odmnvv7m 376 29 . . NNP cord-276616-odmnvv7m 376 30 , , , cord-276616-odmnvv7m 376 31 1992 1992 CD cord-276616-odmnvv7m 376 32 ) ) -RRB- cord-276616-odmnvv7m 376 33 . . . cord-276616-odmnvv7m 377 1 No no DT cord-276616-odmnvv7m 377 2 correlation correlation NN cord-276616-odmnvv7m 377 3 was be VBD cord-276616-odmnvv7m 377 4 found find VBN cord-276616-odmnvv7m 377 5 between between IN cord-276616-odmnvv7m 377 6 susceptibility susceptibility NN cord-276616-odmnvv7m 377 7 and and CC cord-276616-odmnvv7m 377 8 the the DT cord-276616-odmnvv7m 377 9 phenotypes phenotype NNS cord-276616-odmnvv7m 377 10 for for IN cord-276616-odmnvv7m 377 11 haemoglobin haemoglobin NN cord-276616-odmnvv7m 377 12 , , , cord-276616-odmnvv7m 377 13 blood blood NN cord-276616-odmnvv7m 377 14 potassium potassium NN cord-276616-odmnvv7m 377 15 levels level NNS cord-276616-odmnvv7m 377 16 , , , cord-276616-odmnvv7m 377 17 lactoglobulins lactoglobulin NNS cord-276616-odmnvv7m 377 18 , , , cord-276616-odmnvv7m 377 19 albumin albumin NN cord-276616-odmnvv7m 377 20 , , , cord-276616-odmnvv7m 377 21 pre pre JJ cord-276616-odmnvv7m 377 22 - - JJ cord-276616-odmnvv7m 377 23 albumin albumin JJ cord-276616-odmnvv7m 377 24 , , , cord-276616-odmnvv7m 377 25 esterase esterase NN cord-276616-odmnvv7m 377 26 , , , cord-276616-odmnvv7m 377 27 haemoglobin haemoglobin NN cord-276616-odmnvv7m 377 28 , , , cord-276616-odmnvv7m 377 29 transferrin transferrin NN cord-276616-odmnvv7m 377 30 , , , cord-276616-odmnvv7m 377 31 reduced reduce VBN cord-276616-odmnvv7m 377 32 glutathione glutathione NN cord-276616-odmnvv7m 377 33 or or CC cord-276616-odmnvv7m 377 34 a a DT cord-276616-odmnvv7m 377 35 - - HYPH cord-276616-odmnvv7m 377 36 mannosidase mannosidase NN cord-276616-odmnvv7m 377 37 Hunter Hunter NNP cord-276616-odmnvv7m 377 38 , , , cord-276616-odmnvv7m 377 39 1991 1991 CD cord-276616-odmnvv7m 377 40 ) ) -RRB- cord-276616-odmnvv7m 377 41 . . . cord-276616-odmnvv7m 378 1 Characterization characterization NN cord-276616-odmnvv7m 378 2 of of IN cord-276616-odmnvv7m 378 3 the the DT cord-276616-odmnvv7m 378 4 env env NN cord-276616-odmnvv7m 378 5 gene gene NN cord-276616-odmnvv7m 378 6 and and CC cord-276616-odmnvv7m 378 7 long long JJ cord-276616-odmnvv7m 378 8 terminal terminal JJ cord-276616-odmnvv7m 378 9 repeat repeat NN cord-276616-odmnvv7m 378 10 of of IN cord-276616-odmnvv7m 378 11 molecularly molecularly RB cord-276616-odmnvv7m 378 12 cloned clone VBN cord-276616-odmnvv7m 378 13 Friend friend NN cord-276616-odmnvv7m 378 14 mink mink NN cord-276616-odmnvv7m 378 15 cell cell NN cord-276616-odmnvv7m 378 16 focus focus NN cord-276616-odmnvv7m 378 17 - - HYPH cord-276616-odmnvv7m 378 18 inducing induce VBG cord-276616-odmnvv7m 378 19 virus virus NN cord-276616-odmnvv7m 379 1 A a DT cord-276616-odmnvv7m 379 2 note note NN cord-276616-odmnvv7m 379 3 on on IN cord-276616-odmnvv7m 379 4 serum serum NN cord-276616-odmnvv7m 379 5 proteins protein NNS cord-276616-odmnvv7m 379 6 in in IN cord-276616-odmnvv7m 379 7 normal normal JJ cord-276616-odmnvv7m 379 8 and and CC cord-276616-odmnvv7m 379 9 scrapie scrapie NN cord-276616-odmnvv7m 379 10 infected infected JJ cord-276616-odmnvv7m 379 11 sheep sheep NN cord-276616-odmnvv7m 380 1 Fnrther fnrther JJ cord-276616-odmnvv7m 380 2 observations observation NNS cord-276616-odmnvv7m 380 3 on on IN cord-276616-odmnvv7m 380 4 the the DT cord-276616-odmnvv7m 380 5 neuropathology neuropathology NN cord-276616-odmnvv7m 380 6 of of IN cord-276616-odmnvv7m 380 7 experimental experimental JJ cord-276616-odmnvv7m 380 8 scrapie scrapie NN cord-276616-odmnvv7m 380 9 in in IN cord-276616-odmnvv7m 380 10 mouse mouse NN cord-276616-odmnvv7m 380 11 and and CC cord-276616-odmnvv7m 380 12 hamster hamster NN cord-276616-odmnvv7m 380 13 Oral oral JJ cord-276616-odmnvv7m 380 14 transmission transmission NN cord-276616-odmnvv7m 380 15 studies study NNS cord-276616-odmnvv7m 380 16 of of IN cord-276616-odmnvv7m 380 17 BSE BSE NNP cord-276616-odmnvv7m 380 18 to to IN cord-276616-odmnvv7m 380 19 mice mouse NNS cord-276616-odmnvv7m 380 20 Antiserum Antiserum NNP cord-276616-odmnvv7m 380 21 to to IN cord-276616-odmnvv7m 380 22 scrapie scrapie NN cord-276616-odmnvv7m 380 23 - - HYPH cord-276616-odmnvv7m 380 24 associated associate VBN cord-276616-odmnvv7m 380 25 fibril fibril NN cord-276616-odmnvv7m 380 26 - - HYPH cord-276616-odmnvv7m 380 27 protein protein NN cord-276616-odmnvv7m 380 28 cross cross NN cord-276616-odmnvv7m 380 29 - - NNS cord-276616-odmnvv7m 380 30 reacts react VBZ cord-276616-odmnvv7m 380 31 with with IN cord-276616-odmnvv7m 380 32 Spiroplasma Spiroplasma NNP cord-276616-odmnvv7m 380 33 mirum mirum NNP cord-276616-odmnvv7m 380 34 fibril fibril NNP cord-276616-odmnvv7m 380 35 proteins protein NNS cord-276616-odmnvv7m 381 1 Scrapie Scrapie NNP cord-276616-odmnvv7m 381 2 agent agent NN cord-276616-odmnvv7m 381 3 proteins protein NNS cord-276616-odmnvv7m 381 4 do do VBP cord-276616-odmnvv7m 381 5 not not RB cord-276616-odmnvv7m 381 6 accumulate accumulate VB cord-276616-odmnvv7m 381 7 in in IN cord-276616-odmnvv7m 381 8 grey grey JJ cord-276616-odmnvv7m 381 9 tumour tumour NN cord-276616-odmnvv7m 381 10 mice mouse NNS cord-276616-odmnvv7m 381 11 Purification purification NN cord-276616-odmnvv7m 381 12 of of IN cord-276616-odmnvv7m 381 13 scrapie scrapie NN cord-276616-odmnvv7m 381 14 agents agent NNS cord-276616-odmnvv7m 381 15 : : : cord-276616-odmnvv7m 381 16 how how WRB cord-276616-odmnvv7m 381 17 far far RB cord-276616-odmnvv7m 381 18 have have VBP cord-276616-odmnvv7m 381 19 we -PRON- PRP cord-276616-odmnvv7m 381 20 come come VB cord-276616-odmnvv7m 381 21 ? ? . cord-276616-odmnvv7m 382 1 Identification identification NN cord-276616-odmnvv7m 382 2 of of IN cord-276616-odmnvv7m 382 3 a a DT cord-276616-odmnvv7m 382 4 protein protein NN cord-276616-odmnvv7m 382 5 that that WDT cord-276616-odmnvv7m 382 6 purifies purify VBZ cord-276616-odmnvv7m 382 7 with with IN cord-276616-odmnvv7m 382 8 the the DT cord-276616-odmnvv7m 382 9 scrapie scrapie NN cord-276616-odmnvv7m 382 10 prion prion NN cord-276616-odmnvv7m 382 11 Copurification Copurification NNP cord-276616-odmnvv7m 382 12 of of IN cord-276616-odmnvv7m 382 13 Sp33 Sp33 NNP cord-276616-odmnvv7m 382 14 - - HYPH cord-276616-odmnvv7m 382 15 37 37 CD cord-276616-odmnvv7m 382 16 and and CC cord-276616-odmnvv7m 382 17 scrapie scrapie NN cord-276616-odmnvv7m 382 18 agent agent NN cord-276616-odmnvv7m 382 19 from from IN cord-276616-odmnvv7m 382 20 hamster hamster NN cord-276616-odmnvv7m 382 21 brain brain NN cord-276616-odmnvv7m 382 22 prior prior RB cord-276616-odmnvv7m 382 23 to to IN cord-276616-odmnvv7m 382 24 detectable detectable JJ cord-276616-odmnvv7m 382 25 histopathology histopathology NN cord-276616-odmnvv7m 382 26 and and CC cord-276616-odmnvv7m 382 27 clinical clinical JJ cord-276616-odmnvv7m 382 28 disease disease NN cord-276616-odmnvv7m 383 1 The the DT cord-276616-odmnvv7m 383 2 human human JJ cord-276616-odmnvv7m 383 3 endogenous endogenous JJ cord-276616-odmnvv7m 383 4 retrovirus retrovirus NN cord-276616-odmnvv7m 383 5 ERV-3 ERV-3 NNP cord-276616-odmnvv7m 383 6 is be VBZ cord-276616-odmnvv7m 383 7 unregulated unregulated JJ cord-276616-odmnvv7m 383 8 in in IN cord-276616-odmnvv7m 383 9 differentiating differentiate VBG cord-276616-odmnvv7m 383 10 placental placental JJ cord-276616-odmnvv7m 383 11 trophoblast trophoblast NN cord-276616-odmnvv7m 383 12 cells cell NNS cord-276616-odmnvv7m 383 13 Sub sub NN cord-276616-odmnvv7m 383 14 - - HYPH cord-276616-odmnvv7m 383 15 acute acute JJ cord-276616-odmnvv7m 383 16 , , , cord-276616-odmnvv7m 383 17 transmissible transmissible JJ cord-276616-odmnvv7m 383 18 spongiform spongiform JJ cord-276616-odmnvv7m 383 19 encephalopathies encephalopathy NNS cord-276616-odmnvv7m 383 20 : : : cord-276616-odmnvv7m 384 1 current current JJ cord-276616-odmnvv7m 384 2 concepts concept NNS cord-276616-odmnvv7m 384 3 and and CC cord-276616-odmnvv7m 384 4 future future NN cord-276616-odmnvv7m 384 5 needs need VBZ cord-276616-odmnvv7m 384 6 Scrapie Scrapie NNP cord-276616-odmnvv7m 384 7 , , , cord-276616-odmnvv7m 384 8 concept concept NN cord-276616-odmnvv7m 384 9 of of IN cord-276616-odmnvv7m 384 10 a a DT cord-276616-odmnvv7m 384 11 virus virus NN cord-276616-odmnvv7m 384 12 - - HYPH cord-276616-odmnvv7m 384 13 induced induce VBN cord-276616-odmnvv7m 384 14 amyloidosis amyloidosis NN cord-276616-odmnvv7m 384 15 of of IN cord-276616-odmnvv7m 384 16 the the DT cord-276616-odmnvv7m 384 17 brain brain NN cord-276616-odmnvv7m 384 18 Transmissible transmissible JJ cord-276616-odmnvv7m 384 19 spongifolan spongifolan NN cord-276616-odmnvv7m 384 20 encephalopathies encephalopathy NNS cord-276616-odmnvv7m 384 21 in in IN cord-276616-odmnvv7m 384 22 human human NN cord-276616-odmnvv7m 384 23 . . . cord-276616-odmnvv7m 385 1 Kuru Kuru NNP cord-276616-odmnvv7m 385 2 , , , cord-276616-odmnvv7m 385 3 Creutzfeldt Creutzfeldt NNP cord-276616-odmnvv7m 385 4 - - HYPH cord-276616-odmnvv7m 385 5 Jakob Jakob NNP cord-276616-odmnvv7m 385 6 disease disease NN cord-276616-odmnvv7m 385 7 and and CC cord-276616-odmnvv7m 385 8 Gerstmann Gerstmann NNP cord-276616-odmnvv7m 385 9 - - HYPH cord-276616-odmnvv7m 385 10 Str Str NNP cord-276616-odmnvv7m 386 1 ~iussler ~iussler NNP cord-276616-odmnvv7m 386 2 - - HYPH cord-276616-odmnvv7m 386 3 Scheinker Scheinker NNP cord-276616-odmnvv7m 386 4 disease disease NN cord-276616-odmnvv7m 387 1 The the DT cord-276616-odmnvv7m 387 2 human human JJ cord-276616-odmnvv7m 387 3 spongiform spongiform NN cord-276616-odmnvv7m 387 4 encephalopathies encephalopathy NNS cord-276616-odmnvv7m 387 5 : : : cord-276616-odmnvv7m 387 6 Kuru Kuru NNP cord-276616-odmnvv7m 387 7 , , , cord-276616-odmnvv7m 387 8 Creutzfeldt Creutzfeldt NNP cord-276616-odmnvv7m 387 9 - - HYPH cord-276616-odmnvv7m 387 10 Jakob Jakob NNP cord-276616-odmnvv7m 387 11 disease disease NN cord-276616-odmnvv7m 387 12 and and CC cord-276616-odmnvv7m 387 13 the the DT cord-276616-odmnvv7m 387 14 Gerstmann Gerstmann NNP cord-276616-odmnvv7m 387 15 - - HYPH cord-276616-odmnvv7m 387 16 Str Str NNP cord-276616-odmnvv7m 387 17 ~ ~ NFP cord-276616-odmnvv7m 387 18 iussler iussler NNP cord-276616-odmnvv7m 387 19 - - HYPH cord-276616-odmnvv7m 387 20 Scheinker Scheinker NNP cord-276616-odmnvv7m 387 21 syndrome syndrome NN cord-276616-odmnvv7m 387 22 Biological biological JJ cord-276616-odmnvv7m 387 23 stability stability NN cord-276616-odmnvv7m 387 24 of of IN cord-276616-odmnvv7m 387 25 different different JJ cord-276616-odmnvv7m 387 26 classes class NNS cord-276616-odmnvv7m 387 27 of of IN cord-276616-odmnvv7m 387 28 scrapie scrapie NN cord-276616-odmnvv7m 387 29 agent agent NN cord-276616-odmnvv7m 387 30 Biochemistry Biochemistry NNP cord-276616-odmnvv7m 387 31 of of IN cord-276616-odmnvv7m 387 32 oxygen oxygen NN cord-276616-odmnvv7m 387 33 radical radical JJ cord-276616-odmnvv7m 387 34 species specie NNS cord-276616-odmnvv7m 388 1 Mice mice NN cord-276616-odmnvv7m 388 2 devoid devoid JJ cord-276616-odmnvv7m 388 3 of of IN cord-276616-odmnvv7m 388 4 PrP prp NN cord-276616-odmnvv7m 388 5 are be VBP cord-276616-odmnvv7m 388 6 resistant resistant JJ cord-276616-odmnvv7m 388 7 to to IN cord-276616-odmnvv7m 388 8 scrapie scrapie NN cord-276616-odmnvv7m 388 9 Identification identification NN cord-276616-odmnvv7m 388 10 and and CC cord-276616-odmnvv7m 388 11 characterization characterization NN cord-276616-odmnvv7m 388 12 of of IN cord-276616-odmnvv7m 388 13 proteinase proteinase NN cord-276616-odmnvv7m 388 14 - - HYPH cord-276616-odmnvv7m 388 15 K k NN cord-276616-odmnvv7m 388 16 resistant resistant JJ cord-276616-odmnvv7m 388 17 proteins protein NNS cord-276616-odmnvv7m 388 18 in in IN cord-276616-odmnvv7m 388 19 members member NNS cord-276616-odmnvv7m 388 20 of of IN cord-276616-odmnvv7m 388 21 the the DT cord-276616-odmnvv7m 388 22 Class Class NNP cord-276616-odmnvv7m 388 23 Mollicutes Mollicutes NNP cord-276616-odmnvv7m 388 24 Detection Detection NNP cord-276616-odmnvv7m 388 25 of of IN cord-276616-odmnvv7m 388 26 prion prion NN cord-276616-odmnvv7m 388 27 protein protein NN cord-276616-odmnvv7m 388 28 mRNA mrna NN cord-276616-odmnvv7m 388 29 in in IN cord-276616-odmnvv7m 388 30 normal normal JJ cord-276616-odmnvv7m 388 31 and and CC cord-276616-odmnvv7m 388 32 scrapie scrapie NN cord-276616-odmnvv7m 388 33 - - HYPH cord-276616-odmnvv7m 388 34 infected infect VBN cord-276616-odmnvv7m 388 35 tissues tissue NNS cord-276616-odmnvv7m 388 36 and and CC cord-276616-odmnvv7m 388 37 cell cell NN cord-276616-odmnvv7m 388 38 lines line NNS cord-276616-odmnvv7m 388 39 N n NN cord-276616-odmnvv7m 388 40 - - HYPH cord-276616-odmnvv7m 388 41 terminal terminal NN cord-276616-odmnvv7m 388 42 truncation truncation NN cord-276616-odmnvv7m 388 43 of of IN cord-276616-odmnvv7m 388 44 the the DT cord-276616-odmnvv7m 388 45 scrapie scrapie NN cord-276616-odmnvv7m 388 46 - - HYPH cord-276616-odmnvv7m 388 47 associated associate VBN cord-276616-odmnvv7m 388 48 form form NN cord-276616-odmnvv7m 388 49 of of IN cord-276616-odmnvv7m 388 50 PrP prp NN cord-276616-odmnvv7m 388 51 by by IN cord-276616-odmnvv7m 388 52 lysomal lysomal NNP cord-276616-odmnvv7m 388 53 protease(s protease(s NNP cord-276616-odmnvv7m 389 1 ): ): NNP cord-276616-odmnvv7m 389 2 Implications implication NNS cord-276616-odmnvv7m 389 3 regarding regard VBG cord-276616-odmnvv7m 389 4 the the DT cord-276616-odmnvv7m 389 5 site site NN cord-276616-odmnvv7m 389 6 of of IN cord-276616-odmnvv7m 389 7 conversion conversion NN cord-276616-odmnvv7m 389 8 of of IN cord-276616-odmnvv7m 389 9 PrP prp NN cord-276616-odmnvv7m 389 10 to to IN cord-276616-odmnvv7m 389 11 the the DT cord-276616-odmnvv7m 389 12 protease protease NN cord-276616-odmnvv7m 389 13 - - HYPH cord-276616-odmnvv7m 389 14 resistant resistant JJ cord-276616-odmnvv7m 389 15 state state NN cord-276616-odmnvv7m 389 16 Encephalopathy Encephalopathy NNP cord-276616-odmnvv7m 389 17 in in IN cord-276616-odmnvv7m 389 18 mice mouse NNS cord-276616-odmnvv7m 389 19 produced produce VBN cord-276616-odmnvv7m 389 20 by by IN cord-276616-odmnvv7m 389 21 inoculation inoculation NN cord-276616-odmnvv7m 389 22 of of IN cord-276616-odmnvv7m 389 23 scrapie scrapie NN cord-276616-odmnvv7m 389 24 brain brain NN cord-276616-odmnvv7m 389 25 Characteristics characteristic NNS cord-276616-odmnvv7m 389 26 and and CC cord-276616-odmnvv7m 389 27 contributions contribution NNS cord-276616-odmnvv7m 389 28 of of IN cord-276616-odmnvv7m 389 29 defective defective JJ cord-276616-odmnvv7m 389 30 , , , cord-276616-odmnvv7m 389 31 ecotropic ecotropic NNP cord-276616-odmnvv7m 389 32 , , , cord-276616-odmnvv7m 389 33 and and CC cord-276616-odmnvv7m 389 34 mink mink NN cord-276616-odmnvv7m 389 35 - - HYPH cord-276616-odmnvv7m 389 36 cell cell NN cord-276616-odmnvv7m 389 37 focus focus NN cord-276616-odmnvv7m 389 38 - - HYPH cord-276616-odmnvv7m 389 39 inducing induce VBG cord-276616-odmnvv7m 389 40 viruses virus NNS cord-276616-odmnvv7m 389 41 involved involve VBN cord-276616-odmnvv7m 389 42 in in IN cord-276616-odmnvv7m 389 43 a a DT cord-276616-odmnvv7m 389 44 retrovirus retrovirus NN cord-276616-odmnvv7m 389 45 - - HYPH cord-276616-odmnvv7m 389 46 induced induce VBN cord-276616-odmnvv7m 389 47 immunodeficiency immunodeficiency NN cord-276616-odmnvv7m 389 48 syndrome syndrome NN cord-276616-odmnvv7m 389 49 of of IN cord-276616-odmnvv7m 389 50 mice mouse NNS cord-276616-odmnvv7m 390 1 Spongiform spongiform JJ cord-276616-odmnvv7m 390 2 encephalopathies encephalopathy NNS cord-276616-odmnvv7m 390 3 : : : cord-276616-odmnvv7m 391 1 the the DT cord-276616-odmnvv7m 391 2 transmissible transmissible JJ cord-276616-odmnvv7m 391 3 agents agent NNS cord-276616-odmnvv7m 391 4 Spongiform spongiform JJ cord-276616-odmnvv7m 391 5 encephalopathies encephalopathy NNS cord-276616-odmnvv7m 391 6 : : : cord-276616-odmnvv7m 391 7 PrP prp NN cord-276616-odmnvv7m 391 8 and and CC cord-276616-odmnvv7m 391 9 the the DT cord-276616-odmnvv7m 391 10 scrapie scrapie NN cord-276616-odmnvv7m 391 11 agent agent NN cord-276616-odmnvv7m 391 12 Requirement Requirement NNP cord-276616-odmnvv7m 391 13 of of IN cord-276616-odmnvv7m 391 14 a a DT cord-276616-odmnvv7m 391 15 protein protein NN cord-276616-odmnvv7m 391 16 component component NN cord-276616-odmnvv7m 391 17 for for IN cord-276616-odmnvv7m 391 18 scrapie scrapie NN cord-276616-odmnvv7m 391 19 infectivity infectivity NN cord-276616-odmnvv7m 391 20 Inactivation Inactivation NNP cord-276616-odmnvv7m 391 21 of of IN cord-276616-odmnvv7m 391 22 the the DT cord-276616-odmnvv7m 391 23 scrapie scrapie NN cord-276616-odmnvv7m 391 24 agent agent NN cord-276616-odmnvv7m 391 25 by by IN cord-276616-odmnvv7m 391 26 Pronase Pronase NNP cord-276616-odmnvv7m 391 27 Antibody Antibody NNP cord-276616-odmnvv7m 391 28 to to IN cord-276616-odmnvv7m 391 29 a a DT cord-276616-odmnvv7m 391 30 scrapie scrapie NN cord-276616-odmnvv7m 391 31 - - HYPH cord-276616-odmnvv7m 391 32 associated associate VBN cord-276616-odmnvv7m 391 33 fibril fibril NNP cord-276616-odmnvv7m 391 34 protein protein NN cord-276616-odmnvv7m 391 35 identifies identify VBZ cord-276616-odmnvv7m 391 36 a a DT cord-276616-odmnvv7m 391 37 cellular cellular JJ cord-276616-odmnvv7m 391 38 antigen antigen NN cord-276616-odmnvv7m 391 39 Bovine bovine JJ cord-276616-odmnvv7m 391 40 spongiforna spongiforna NN cord-276616-odmnvv7m 391 41 encephalopathy encephalopathy NN cord-276616-odmnvv7m 391 42 and and CC cord-276616-odmnvv7m 391 43 man man NN cord-276616-odmnvv7m 391 44 Bovine bovine JJ cord-276616-odmnvv7m 391 45 spongiform spongiform JJ cord-276616-odmnvv7m 391 46 encephalopathy encephalopathy NN cord-276616-odmnvv7m 391 47 and and CC cord-276616-odmnvv7m 391 48 risk risk NN cord-276616-odmnvv7m 391 49 to to TO cord-276616-odmnvv7m 391 50 health health NN cord-276616-odmnvv7m 391 51 Transmissible transmissible JJ cord-276616-odmnvv7m 391 52 spongiform spongiform JJ cord-276616-odmnvv7m 391 53 cncephalopathy cncephalopathy NN cord-276616-odmnvv7m 391 54 in in IN cord-276616-odmnvv7m 391 55 greater great JJR cord-276616-odmnvv7m 391 56 kudu kudu NNS cord-276616-odmnvv7m 391 57 ( ( -LRB- cord-276616-odmnvv7m 391 58 Tragelaphus Tragelaphus NNP cord-276616-odmnvv7m 391 59 strepsiceos strepsiceos NNP cord-276616-odmnvv7m 391 60 ) ) -RRB- cord-276616-odmnvv7m 392 1 The the DT cord-276616-odmnvv7m 392 2 major major JJ cord-276616-odmnvv7m 392 3 protein protein NN cord-276616-odmnvv7m 392 4 of of IN cord-276616-odmnvv7m 392 5 SAF SAF NNP cord-276616-odmnvv7m 392 6 is be VBZ cord-276616-odmnvv7m 392 7 absent absent JJ cord-276616-odmnvv7m 392 8 from from IN cord-276616-odmnvv7m 392 9 spleen spleen NNS cord-276616-odmnvv7m 392 10 and and CC cord-276616-odmnvv7m 392 11 thus thus RB cord-276616-odmnvv7m 392 12 not not RB cord-276616-odmnvv7m 392 13 an an DT cord-276616-odmnvv7m 392 14 essential essential JJ cord-276616-odmnvv7m 392 15 part part NN cord-276616-odmnvv7m 392 16 of of IN cord-276616-odmnvv7m 392 17 the the DT cord-276616-odmnvv7m 392 18 scrapie scrapie NN cord-276616-odmnvv7m 392 19 agent agent NN cord-276616-odmnvv7m 392 20 Biochemical Biochemical NNP cord-276616-odmnvv7m 392 21 aids aid VBZ cord-276616-odmnvv7m 392 22 to to IN cord-276616-odmnvv7m 392 23 the the DT cord-276616-odmnvv7m 392 24 genetic genetic JJ cord-276616-odmnvv7m 392 25 typing typing NN cord-276616-odmnvv7m 392 26 of of IN cord-276616-odmnvv7m 392 27 sheep sheep NN cord-276616-odmnvv7m 392 28 -a -a : cord-276616-odmnvv7m 392 29 further further RB cord-276616-odmnvv7m 392 30 note note NN cord-276616-odmnvv7m 392 31 Pronase Pronase NNP cord-276616-odmnvv7m 392 32 does do VBZ cord-276616-odmnvv7m 392 33 not not RB cord-276616-odmnvv7m 392 34 reduce reduce VB cord-276616-odmnvv7m 392 35 the the DT cord-276616-odmnvv7m 392 36 protein protein NN cord-276616-odmnvv7m 392 37 content content NN cord-276616-odmnvv7m 392 38 of of IN cord-276616-odmnvv7m 392 39 Hirt Hirt NNP cord-276616-odmnvv7m 392 40 supernatant supernatant JJ cord-276616-odmnvv7m 392 41 of of IN cord-276616-odmnvv7m 392 42 normal normal JJ cord-276616-odmnvv7m 392 43 mouse mouse NN cord-276616-odmnvv7m 392 44 brain brain NN cord-276616-odmnvv7m 392 45 Potassium potassium NN cord-276616-odmnvv7m 392 46 and and CC cord-276616-odmnvv7m 392 47 hemoglobin hemoglobin NN cord-276616-odmnvv7m 392 48 types type NNS cord-276616-odmnvv7m 392 49 in in IN cord-276616-odmnvv7m 392 50 sheep sheep NN cord-276616-odmnvv7m 392 51 with with IN cord-276616-odmnvv7m 392 52 special special JJ cord-276616-odmnvv7m 392 53 reference reference NN cord-276616-odmnvv7m 392 54 to to IN cord-276616-odmnvv7m 392 55 the the DT cord-276616-odmnvv7m 392 56 transmission transmission NN cord-276616-odmnvv7m 392 57 of of IN cord-276616-odmnvv7m 392 58 scrapie scrapie NN cord-276616-odmnvv7m 392 59 Recovery recovery NN cord-276616-odmnvv7m 392 60 of of IN cord-276616-odmnvv7m 392 61 infectious infectious JJ cord-276616-odmnvv7m 392 62 bovine bovine JJ cord-276616-odmnvv7m 392 63 rhinotracheitis rhinotracheitis NN cord-276616-odmnvv7m 392 64 virus virus NN cord-276616-odmnvv7m 392 65 following follow VBG cord-276616-odmnvv7m 392 66 corticosteroid corticosteroid JJ cord-276616-odmnvv7m 392 67 treatment treatment NN cord-276616-odmnvv7m 392 68 of of IN cord-276616-odmnvv7m 392 69 vaccinated vaccinated JJ cord-276616-odmnvv7m 392 70 animals animal NNS cord-276616-odmnvv7m 392 71 Brain Brain NNP cord-276616-odmnvv7m 392 72 glycogen glycogen NN cord-276616-odmnvv7m 392 73 - - HYPH cord-276616-odmnvv7m 392 74 and and CC cord-276616-odmnvv7m 392 75 copper copper NN cord-276616-odmnvv7m 392 76 - - HYPH cord-276616-odmnvv7m 392 77 levels level NNS cord-276616-odmnvv7m 392 78 in in IN cord-276616-odmnvv7m 392 79 normal normal JJ cord-276616-odmnvv7m 392 80 sheep sheep NN cord-276616-odmnvv7m 392 81 and and CC cord-276616-odmnvv7m 392 82 sheep sheep NNS cord-276616-odmnvv7m 392 83 affected affect VBN cord-276616-odmnvv7m 392 84 with with IN cord-276616-odmnvv7m 392 85 serapie serapie NNP cord-276616-odmnvv7m 392 86 Scrapie Scrapie NNP cord-276616-odmnvv7m 392 87 : : : cord-276616-odmnvv7m 392 88 I. I. NNP cord-276616-odmnvv7m 392 89 Transmission transmission NN cord-276616-odmnvv7m 392 90 and and CC cord-276616-odmnvv7m 392 91 pathogenesis pathogenesis NN cord-276616-odmnvv7m 392 92 Primary primary JJ cord-276616-odmnvv7m 392 93 parental parental JJ cord-276616-odmnvv7m 392 94 transmission transmission NN cord-276616-odmnvv7m 392 95 of of IN cord-276616-odmnvv7m 392 96 bovine bovine JJ cord-276616-odmnvv7m 392 97 spongiform spongiform JJ cord-276616-odmnvv7m 392 98 encephalopathy encephalopathy NN cord-276616-odmnvv7m 392 99 to to IN cord-276616-odmnvv7m 392 100 the the DT cord-276616-odmnvv7m 392 101 pig pig NN cord-276616-odmnvv7m 392 102 Bovine bovine JJ cord-276616-odmnvv7m 392 103 spongiform spongiform JJ cord-276616-odmnvv7m 392 104 encephalopathy encephalopathy NN cord-276616-odmnvv7m 392 105 and and CC cord-276616-odmnvv7m 392 106 man man NN cord-276616-odmnvv7m 392 107 Pharmacological pharmacological JJ cord-276616-odmnvv7m 392 108 studies study NNS cord-276616-odmnvv7m 392 109 of of IN cord-276616-odmnvv7m 392 110 a a DT cord-276616-odmnvv7m 392 111 new new JJ cord-276616-odmnvv7m 392 112 derivative derivative NN cord-276616-odmnvv7m 392 113 of of IN cord-276616-odmnvv7m 392 114 amphotericin amphotericin NNS cord-276616-odmnvv7m 392 115 B B NNP cord-276616-odmnvv7m 392 116 , , , cord-276616-odmnvv7m 392 117 MS-8209 ms-8209 NN cord-276616-odmnvv7m 392 118 in in IN cord-276616-odmnvv7m 392 119 mouse mouse NN cord-276616-odmnvv7m 392 120 and and CC cord-276616-odmnvv7m 392 121 hamster hamster NN cord-276616-odmnvv7m 392 122 scrapie scrapie NN cord-276616-odmnvv7m 392 123 Similar similar JJ cord-276616-odmnvv7m 392 124 genetic genetic JJ cord-276616-odmnvv7m 392 125 susceptibility susceptibility NN cord-276616-odmnvv7m 392 126 in in IN cord-276616-odmnvv7m 392 127 iatrogenie iatrogenie NNP cord-276616-odmnvv7m 392 128 and and CC cord-276616-odmnvv7m 392 129 sporadic sporadic JJ cord-276616-odmnvv7m 392 130 Creutzfeldt Creutzfeldt NNP cord-276616-odmnvv7m 392 131 - - HYPH cord-276616-odmnvv7m 392 132 Jakob Jakob NNP cord-276616-odmnvv7m 392 133 disease disease NN cord-276616-odmnvv7m 393 1 A a DT cord-276616-odmnvv7m 393 2 direct direct JJ cord-276616-odmnvv7m 393 3 demonstration demonstration NN cord-276616-odmnvv7m 393 4 of of IN cord-276616-odmnvv7m 393 5 recombination recombination NN cord-276616-odmnvv7m 393 6 between between IN cord-276616-odmnvv7m 393 7 injected inject VBN cord-276616-odmnvv7m 393 8 virus virus NN cord-276616-odmnvv7m 393 9 and and CC cord-276616-odmnvv7m 393 10 endogenous endogenous JJ cord-276616-odmnvv7m 393 11 viral viral JJ cord-276616-odmnvv7m 393 12 sequences sequence NNS cord-276616-odmnvv7m 393 13 , , , cord-276616-odmnvv7m 393 14 resulting result VBG cord-276616-odmnvv7m 393 15 in in IN cord-276616-odmnvv7m 393 16 the the DT cord-276616-odmnvv7m 393 17 generation generation NN cord-276616-odmnvv7m 393 18 of of IN cord-276616-odmnvv7m 393 19 mink mink NN cord-276616-odmnvv7m 393 20 cell cell NN cord-276616-odmnvv7m 393 21 - - HYPH cord-276616-odmnvv7m 393 22 focus focus NN cord-276616-odmnvv7m 393 23 - - HYPH cord-276616-odmnvv7m 393 24 inducing induce VBG cord-276616-odmnvv7m 393 25 viruses virus NNS cord-276616-odmnvv7m 393 26 in in IN cord-276616-odmnvv7m 393 27 AKR AKR NNP cord-276616-odmnvv7m 393 28 mice mouse NNS cord-276616-odmnvv7m 394 1 The the DT cord-276616-odmnvv7m 394 2 scrapie scrapie NN cord-276616-odmnvv7m 394 3 replication replication NN cord-276616-odmnvv7m 394 4 site site NN cord-276616-odmnvv7m 394 5 hypothesis hypothesis NN cord-276616-odmnvv7m 395 1 Genetic genetic JJ cord-276616-odmnvv7m 395 2 aspects aspect NNS cord-276616-odmnvv7m 395 3 of of IN cord-276616-odmnvv7m 395 4 unconventional unconventional JJ cord-276616-odmnvv7m 395 5 virus virus NN cord-276616-odmnvv7m 395 6 infections infection NNS cord-276616-odmnvv7m 395 7 : : : cord-276616-odmnvv7m 396 1 the the DT cord-276616-odmnvv7m 396 2 basis basis NN cord-276616-odmnvv7m 396 3 of of IN cord-276616-odmnvv7m 396 4 the the DT cord-276616-odmnvv7m 396 5 virino virino NNP cord-276616-odmnvv7m 396 6 hypothesis hypothesis NN cord-276616-odmnvv7m 396 7 Maternal maternal JJ cord-276616-odmnvv7m 396 8 and and CC cord-276616-odmnvv7m 396 9 lateral lateral JJ cord-276616-odmnvv7m 396 10 transmission transmission NN cord-276616-odmnvv7m 396 11 of of IN cord-276616-odmnvv7m 396 12 scrapie scrapie NN cord-276616-odmnvv7m 396 13 in in IN cord-276616-odmnvv7m 396 14 sheep sheep NN cord-276616-odmnvv7m 396 15 Comparative Comparative NNP cord-276616-odmnvv7m 396 16 features feature NNS cord-276616-odmnvv7m 396 17 of of IN cord-276616-odmnvv7m 396 18 retroviral retroviral JJ cord-276616-odmnvv7m 396 19 infections infection NNS cord-276616-odmnvv7m 396 20 of of IN cord-276616-odmnvv7m 396 21 livestock livestock NN cord-276616-odmnvv7m 396 22 Bovine bovine JJ cord-276616-odmnvv7m 396 23 spongiform spongiform JJ cord-276616-odmnvv7m 396 24 encephalopathy encephalopathy NN cord-276616-odmnvv7m 397 1 The the DT cord-276616-odmnvv7m 397 2 Biology Biology NNP cord-276616-odmnvv7m 397 3 of of IN cord-276616-odmnvv7m 397 4 Animal Animal NNP cord-276616-odmnvv7m 397 5 Viruses Viruses NNPS cord-276616-odmnvv7m 397 6 Veterinary Veterinary NNP cord-276616-odmnvv7m 397 7 Virology Virology NNP cord-276616-odmnvv7m 397 8 Specificity Specificity NNP cord-276616-odmnvv7m 397 9 of of IN cord-276616-odmnvv7m 397 10 disease disease NN cord-276616-odmnvv7m 397 11 induced induce VBN cord-276616-odmnvv7m 397 12 by by IN cord-276616-odmnvv7m 397 13 M M NNP cord-276616-odmnvv7m 397 14 - - HYPH cord-276616-odmnvv7m 397 15 MuLV MuLV NNP cord-276616-odmnvv7m 397 16 chimeric chimeric JJ cord-276616-odmnvv7m 397 17 retroviruses retrovirus NNS cord-276616-odmnvv7m 397 18 containing contain VBG cord-276616-odmnvv7m 397 19 v v LS cord-276616-odmnvv7m 397 20 - - HYPH cord-276616-odmnvv7m 397 21 myc myc NNP cord-276616-odmnvv7m 397 22 or or CC cord-276616-odmnvv7m 397 23 v v NNP cord-276616-odmnvv7m 397 24 - - HYPH cord-276616-odmnvv7m 397 25 src src NNP cord-276616-odmnvv7m 397 26 is be VBZ cord-276616-odmnvv7m 397 27 not not RB cord-276616-odmnvv7m 397 28 determined determine VBN cord-276616-odmnvv7m 397 29 by by IN cord-276616-odmnvv7m 397 30 the the DT cord-276616-odmnvv7m 397 31 LTR LTR NNP cord-276616-odmnvv7m 397 32 Studies Studies NNPS cord-276616-odmnvv7m 397 33 on on IN cord-276616-odmnvv7m 397 34 the the DT cord-276616-odmnvv7m 397 35 natural natural JJ cord-276616-odmnvv7m 397 36 transmission transmission NN cord-276616-odmnvv7m 397 37 of of IN cord-276616-odmnvv7m 397 38 scrapie scrapie NN cord-276616-odmnvv7m 397 39 in in IN cord-276616-odmnvv7m 397 40 sheep sheep NN cord-276616-odmnvv7m 397 41 by by IN cord-276616-odmnvv7m 397 42 embryo embryo NN cord-276616-odmnvv7m 397 43 transfer transfer NN cord-276616-odmnvv7m 397 44 Transmission transmission NN cord-276616-odmnvv7m 397 45 of of IN cord-276616-odmnvv7m 397 46 bovine bovine JJ cord-276616-odmnvv7m 397 47 spongiform spongiform JJ cord-276616-odmnvv7m 397 48 encephalopathy encephalopathy NN cord-276616-odmnvv7m 397 49 and and CC cord-276616-odmnvv7m 397 50 scrapie scrapie NN cord-276616-odmnvv7m 397 51 to to IN cord-276616-odmnvv7m 397 52 mice mouse NNS cord-276616-odmnvv7m 397 53 Unconventional unconventional JJ cord-276616-odmnvv7m 397 54 viruses virus NNS cord-276616-odmnvv7m 397 55 and and CC cord-276616-odmnvv7m 397 56 the the DT cord-276616-odmnvv7m 397 57 origin origin NN cord-276616-odmnvv7m 397 58 and and CC cord-276616-odmnvv7m 397 59 disappearance disappearance NN cord-276616-odmnvv7m 397 60 of of IN cord-276616-odmnvv7m 397 61 kurn kurn NNP cord-276616-odmnvv7m 397 62 Sequencing Sequencing NNP cord-276616-odmnvv7m 397 63 and and CC cord-276616-odmnvv7m 397 64 antigenic antigenic JJ cord-276616-odmnvv7m 397 65 studies study NNS cord-276616-odmnvv7m 397 66 of of IN cord-276616-odmnvv7m 397 67 a a DT cord-276616-odmnvv7m 397 68 Norwegian norwegian JJ cord-276616-odmnvv7m 397 69 virus virus NN cord-276616-odmnvv7m 397 70 isolated isolate VBN cord-276616-odmnvv7m 397 71 from from IN cord-276616-odmnvv7m 397 72 encephalomyelitic encephalomyelitic JJ cord-276616-odmnvv7m 397 73 sheep sheep NN cord-276616-odmnvv7m 397 74 confirna confirna NNP cord-276616-odmnvv7m 398 1 the the DT cord-276616-odmnvv7m 398 2 existence existence NN cord-276616-odmnvv7m 398 3 of of IN cord-276616-odmnvv7m 398 4 louping loupe VBG cord-276616-odmnvv7m 398 5 - - HYPH cord-276616-odmnvv7m 398 6 ill ill JJ cord-276616-odmnvv7m 398 7 virus virus NN cord-276616-odmnvv7m 398 8 outside outside IN cord-276616-odmnvv7m 398 9 Great Great NNP cord-276616-odmnvv7m 398 10 Britain Britain NNP cord-276616-odmnvv7m 398 11 and and CC cord-276616-odmnvv7m 398 12 Ireland Ireland NNP cord-276616-odmnvv7m 398 13 Murine Murine NNP cord-276616-odmnvv7m 398 14 retrovirus retrovirus NN cord-276616-odmnvv7m 398 15 motor motor NN cord-276616-odmnvv7m 398 16 neuron neuron NN cord-276616-odmnvv7m 398 17 disease disease NN cord-276616-odmnvv7m 399 1 Strain strain NN cord-276616-odmnvv7m 399 2 variation variation NN cord-276616-odmnvv7m 399 3 in in IN cord-276616-odmnvv7m 399 4 the the DT cord-276616-odmnvv7m 399 5 viruses virus NNS cord-276616-odmnvv7m 399 6 of of IN cord-276616-odmnvv7m 399 7 Creutzfeldt Creutzfeldt NNP cord-276616-odmnvv7m 399 8 - - HYPH cord-276616-odmnvv7m 399 9 Jakob Jakob NNP cord-276616-odmnvv7m 399 10 disease disease NN cord-276616-odmnvv7m 399 11 and and CC cord-276616-odmnvv7m 399 12 kuru kuru NNP cord-276616-odmnvv7m 399 13 Experimental experimental JJ cord-276616-odmnvv7m 399 14 transmission transmission NN cord-276616-odmnvv7m 399 15 of of IN cord-276616-odmnvv7m 399 16 scrapie scrapie NN cord-276616-odmnvv7m 399 17 to to IN cord-276616-odmnvv7m 399 18 cattle cattle NNS cord-276616-odmnvv7m 399 19 Advances advance NNS cord-276616-odmnvv7m 399 20 in in IN cord-276616-odmnvv7m 399 21 veterinary veterinary JJ cord-276616-odmnvv7m 399 22 research research NN cord-276616-odmnvv7m 399 23 : : : cord-276616-odmnvv7m 399 24 louping loupe VBG cord-276616-odmnvv7m 399 25 - - HYPH cord-276616-odmnvv7m 399 26 ill ill JJ cord-276616-odmnvv7m 399 27 , , , cord-276616-odmnvv7m 399 28 tick tick VB cord-276616-odmnvv7m 399 29 - - HYPH cord-276616-odmnvv7m 399 30 borne bear VBN cord-276616-odmnvv7m 399 31 fever fever NN cord-276616-odmnvv7m 399 32 and and CC cord-276616-odmnvv7m 399 33 scrapie scrapie NN cord-276616-odmnvv7m 399 34 Studies Studies NNPS cord-276616-odmnvv7m 399 35 on on IN cord-276616-odmnvv7m 399 36 a a DT cord-276616-odmnvv7m 399 37 species species NN cord-276616-odmnvv7m 399 38 - - HYPH cord-276616-odmnvv7m 399 39 specific specific JJ cord-276616-odmnvv7m 399 40 epitope epitope NN cord-276616-odmnvv7m 399 41 in in IN cord-276616-odmnvv7m 399 42 routine routine JJ cord-276616-odmnvv7m 399 43 , , , cord-276616-odmnvv7m 399 44 ovine ovine JJ cord-276616-odmnvv7m 399 45 and and CC cord-276616-odmnvv7m 399 46 bovine bovine JJ cord-276616-odmnvv7m 399 47 prion prion NN cord-276616-odmnvv7m 399 48 protein protein NN cord-276616-odmnvv7m 399 49 Antibody Antibody NNP cord-276616-odmnvv7m 399 50 to to TO cord-276616-odmnvv7m 399 51 hepatitis hepatitis NNP cord-276616-odmnvv7m 399 52 B B NNP cord-276616-odmnvv7m 399 53 surface surface NN cord-276616-odmnvv7m 399 54 antigen antigen NN cord-276616-odmnvv7m 399 55 in in IN cord-276616-odmnvv7m 399 56 nonprimate nonprimate NN cord-276616-odmnvv7m 399 57 animal animal NN cord-276616-odmnvv7m 399 58 species specie NNS cord-276616-odmnvv7m 399 59 Scrapie Scrapie NNP cord-276616-odmnvv7m 399 60 as as IN cord-276616-odmnvv7m 399 61 a a DT cord-276616-odmnvv7m 399 62 slow slow JJ cord-276616-odmnvv7m 399 63 and and CC cord-276616-odmnvv7m 399 64 latent latent JJ cord-276616-odmnvv7m 399 65 virus virus NN cord-276616-odmnvv7m 399 66 Concern concern NN cord-276616-odmnvv7m 399 67 about about IN cord-276616-odmnvv7m 399 68 bovine bovine JJ cord-276616-odmnvv7m 399 69 spongiform spongiform JJ cord-276616-odmnvv7m 399 70 encephalopathy encephalopathy NN cord-276616-odmnvv7m 399 71 Linkage linkage NN cord-276616-odmnvv7m 399 72 of of IN cord-276616-odmnvv7m 399 73 a a DT cord-276616-odmnvv7m 399 74 prion prion NN cord-276616-odmnvv7m 399 75 protein protein NN cord-276616-odmnvv7m 399 76 missense missense NN cord-276616-odmnvv7m 399 77 variant variant NN cord-276616-odmnvv7m 399 78 to to IN cord-276616-odmnvv7m 399 79 Gerstmann Gerstmann NNP cord-276616-odmnvv7m 399 80 - - HYPH cord-276616-odmnvv7m 399 81 Str Str NNP cord-276616-odmnvv7m 399 82 ~ ~ NNP cord-276616-odmnvv7m 399 83 iussler iussler NNP cord-276616-odmnvv7m 399 84 syndrome syndrome NN cord-276616-odmnvv7m 399 85 Spiroplasma Spiroplasma NNP cord-276616-odmnvv7m 399 86 and and CC cord-276616-odmnvv7m 399 87 spongiform spongiform JJ cord-276616-odmnvv7m 399 88 encephalopathies encephalopathy NNS cord-276616-odmnvv7m 400 1 The the DT cord-276616-odmnvv7m 400 2 enigma enigma NN cord-276616-odmnvv7m 400 3 of of IN cord-276616-odmnvv7m 400 4 the the DT cord-276616-odmnvv7m 400 5 scrapie scrapie NN cord-276616-odmnvv7m 400 6 agent agent NN cord-276616-odmnvv7m 400 7 : : : cord-276616-odmnvv7m 400 8 biochemical biochemical JJ cord-276616-odmnvv7m 400 9 approaches approach NNS cord-276616-odmnvv7m 400 10 and and CC cord-276616-odmnvv7m 400 11 the the DT cord-276616-odmnvv7m 400 12 involvement involvement NN cord-276616-odmnvv7m 400 13 of of IN cord-276616-odmnvv7m 400 14 membranes membrane NNS cord-276616-odmnvv7m 400 15 and and CC cord-276616-odmnvv7m 400 16 nucleic nucleic JJ cord-276616-odmnvv7m 400 17 acids acid NNS cord-276616-odmnvv7m 400 18 Natural natural JJ cord-276616-odmnvv7m 400 19 transmission transmission NN cord-276616-odmnvv7m 400 20 and and CC cord-276616-odmnvv7m 400 21 genetic genetic JJ cord-276616-odmnvv7m 400 22 control control NN cord-276616-odmnvv7m 400 23 of of IN cord-276616-odmnvv7m 400 24 susceptibility susceptibility NN cord-276616-odmnvv7m 400 25 of of IN cord-276616-odmnvv7m 400 26 sheep sheep NN cord-276616-odmnvv7m 400 27 to to IN cord-276616-odmnvv7m 400 28 scrapie scrapie NN cord-276616-odmnvv7m 400 29 Linkage linkage NN cord-276616-odmnvv7m 400 30 of of IN cord-276616-odmnvv7m 400 31 the the DT cord-276616-odmnvv7m 400 32 scrapie scrapie NN cord-276616-odmnvv7m 400 33 - - HYPH cord-276616-odmnvv7m 400 34 associated associate VBN cord-276616-odmnvv7m 400 35 fibril fibril NNP cord-276616-odmnvv7m 400 36 protein protein NN cord-276616-odmnvv7m 400 37 ( ( -LRB- cord-276616-odmnvv7m 400 38 PrP prp NN cord-276616-odmnvv7m 400 39 ) ) -RRB- cord-276616-odmnvv7m 400 40 gene gene NN cord-276616-odmnvv7m 400 41 and and CC cord-276616-odmnvv7m 400 42 Sinc Sinc NNP cord-276616-odmnvv7m 400 43 using use VBG cord-276616-odmnvv7m 400 44 congenic congenic NNP cord-276616-odmnvv7m 400 45 mice mouse NNS cord-276616-odmnvv7m 400 46 and and CC cord-276616-odmnvv7m 400 47 restriction restriction NN cord-276616-odmnvv7m 400 48 fragment fragment NN cord-276616-odmnvv7m 400 49 length length NN cord-276616-odmnvv7m 400 50 polymorphism polymorphism NN cord-276616-odmnvv7m 400 51 analysis analysis NN cord-276616-odmnvv7m 401 1 Idiopathic idiopathic JJ cord-276616-odmnvv7m 401 2 brainstem brainstem NN cord-276616-odmnvv7m 401 3 neuronal neuronal JJ cord-276616-odmnvv7m 401 4 ehromatolysis ehromatolysis NN cord-276616-odmnvv7m 401 5 and and CC cord-276616-odmnvv7m 401 6 hippocampal hippocampal JJ cord-276616-odmnvv7m 401 7 sclerosis sclerosis NN cord-276616-odmnvv7m 401 8 : : : cord-276616-odmnvv7m 401 9 a a DT cord-276616-odmnvv7m 401 10 novel novel JJ cord-276616-odmnvv7m 401 11 encephalopathy encephalopathy NN cord-276616-odmnvv7m 401 12 in in IN cord-276616-odmnvv7m 401 13 clinically clinically RB cord-276616-odmnvv7m 401 14 suspect suspect JJ cord-276616-odmnvv7m 401 15 cases case NNS cord-276616-odmnvv7m 401 16 of of IN cord-276616-odmnvv7m 401 17 bovine bovine JJ cord-276616-odmnvv7m 401 18 spongiform spongiform JJ cord-276616-odmnvv7m 401 19 encephalopathy encephalopathy NN cord-276616-odmnvv7m 401 20 Ultrastructural ultrastructural JJ cord-276616-odmnvv7m 401 21 features feature NNS cord-276616-odmnvv7m 401 22 of of IN cord-276616-odmnvv7m 401 23 spongiform spongiform JJ cord-276616-odmnvv7m 401 24 encephalopathy encephalopathy NN cord-276616-odmnvv7m 401 25 transmitted transmit VBN cord-276616-odmnvv7m 401 26 to to IN cord-276616-odmnvv7m 401 27 mice mouse NNS cord-276616-odmnvv7m 401 28 from from IN cord-276616-odmnvv7m 401 29 three three CD cord-276616-odmnvv7m 401 30 species specie NNS cord-276616-odmnvv7m 401 31 of of IN cord-276616-odmnvv7m 401 32 bovidae bovidae NN cord-276616-odmnvv7m 402 1 Single single JJ cord-276616-odmnvv7m 402 2 amino amino NN cord-276616-odmnvv7m 402 3 acid acid NN cord-276616-odmnvv7m 402 4 codon codon NN cord-276616-odmnvv7m 402 5 changes change NNS cord-276616-odmnvv7m 402 6 detected detect VBN cord-276616-odmnvv7m 402 7 in in IN cord-276616-odmnvv7m 402 8 louping411 louping411 NNP cord-276616-odmnvv7m 402 9 virus virus NN cord-276616-odmnvv7m 402 10 antibody antibody NN cord-276616-odmnvv7m 402 11 - - HYPH cord-276616-odmnvv7m 402 12 resistant resistant JJ cord-276616-odmnvv7m 402 13 mutants mutant NNS cord-276616-odmnvv7m 402 14 with with IN cord-276616-odmnvv7m 402 15 reduced reduce VBN cord-276616-odmnvv7m 402 16 virulence virulence NN cord-276616-odmnvv7m 402 17 Biochemical biochemical JJ cord-276616-odmnvv7m 402 18 differences difference NNS cord-276616-odmnvv7m 402 19 among among IN cord-276616-odmnvv7m 402 20 scrapie scrapie NN cord-276616-odmnvv7m 402 21 - - HYPH cord-276616-odmnvv7m 402 22 associated associate VBN cord-276616-odmnvv7m 402 23 fibrils fibril NNS cord-276616-odmnvv7m 402 24 support support VBP cord-276616-odmnvv7m 402 25 the the DT cord-276616-odmnvv7m 402 26 biological biological JJ cord-276616-odmnvv7m 402 27 diversity diversity NN cord-276616-odmnvv7m 402 28 of of IN cord-276616-odmnvv7m 402 29 scrapie scrapie NN cord-276616-odmnvv7m 402 30 agents agent NNS cord-276616-odmnvv7m 402 31 Comparisons comparison NNS cord-276616-odmnvv7m 402 32 by by IN cord-276616-odmnvv7m 402 33 paper paper NN cord-276616-odmnvv7m 402 34 chromatography chromatography NN cord-276616-odmnvv7m 402 35 of of IN cord-276616-odmnvv7m 402 36 extracts extract NNS cord-276616-odmnvv7m 402 37 of of IN cord-276616-odmnvv7m 402 38 brain brain NN cord-276616-odmnvv7m 402 39 , , , cord-276616-odmnvv7m 402 40 urine urine NN cord-276616-odmnvv7m 402 41 and and CC cord-276616-odmnvv7m 402 42 plasma plasma NN cord-276616-odmnvv7m 402 43 from from IN cord-276616-odmnvv7m 402 44 normal normal JJ cord-276616-odmnvv7m 402 45 and and CC cord-276616-odmnvv7m 402 46 scrapie scrapie NN cord-276616-odmnvv7m 402 47 sheep sheep NN cord-276616-odmnvv7m 402 48 Expression expression NN cord-276616-odmnvv7m 402 49 of of IN cord-276616-odmnvv7m 402 50 mink mink NN cord-276616-odmnvv7m 402 51 cell cell NN cord-276616-odmnvv7m 402 52 ~ ~ NFP cord-276616-odmnvv7m 402 53 focus focus NN cord-276616-odmnvv7m 402 54 forming form VBG cord-276616-odmnvv7m 402 55 murine murine JJ cord-276616-odmnvv7m 402 56 leukemia leukemia NN cord-276616-odmnvv7m 402 57 virus virus NN cord-276616-odmnvv7m 402 58 - - HYPH cord-276616-odmnvv7m 402 59 related relate VBN cord-276616-odmnvv7m 402 60 transcripts transcript NNS cord-276616-odmnvv7m 402 61 in in IN cord-276616-odmnvv7m 402 62 AKR AKR NNP cord-276616-odmnvv7m 402 63 mice mouse NNS cord-276616-odmnvv7m 402 64 Slow Slow NNP cord-276616-odmnvv7m 402 65 Virus virus NN cord-276616-odmnvv7m 402 66 Diseases disease NNS cord-276616-odmnvv7m 402 67 of of IN cord-276616-odmnvv7m 402 68 Animals Animals NNPS cord-276616-odmnvv7m 402 69 and and CC cord-276616-odmnvv7m 402 70 Man Man NNP cord-276616-odmnvv7m 402 71 Biochemical biochemical JJ cord-276616-odmnvv7m 402 72 and and CC cord-276616-odmnvv7m 402 73 behavioural behavioural JJ cord-276616-odmnvv7m 402 74 changes change NNS cord-276616-odmnvv7m 402 75 in in IN cord-276616-odmnvv7m 402 76 scrapie scrapie NN cord-276616-odmnvv7m 402 77 Transmissible transmissible JJ cord-276616-odmnvv7m 402 78 encephalopathies encephalopathy NNS cord-276616-odmnvv7m 402 79 in in IN cord-276616-odmnvv7m 402 80 animals animal NNS cord-276616-odmnvv7m 402 81 Characteristics characteristic NNS cord-276616-odmnvv7m 402 82 of of IN cord-276616-odmnvv7m 402 83 a a DT cord-276616-odmnvv7m 402 84 short short JJ cord-276616-odmnvv7m 402 85 incubation incubation NN cord-276616-odmnvv7m 402 86 model model NN cord-276616-odmnvv7m 402 87 of of IN cord-276616-odmnvv7m 402 88 scrapie scrapie NN cord-276616-odmnvv7m 402 89 in in IN cord-276616-odmnvv7m 402 90 the the DT cord-276616-odmnvv7m 402 91 golden golden JJ cord-276616-odmnvv7m 402 92 hamster hamster NN cord-276616-odmnvv7m 402 93 Organ Organ NNP cord-276616-odmnvv7m 402 94 distribution distribution NN cord-276616-odmnvv7m 402 95 of of IN cord-276616-odmnvv7m 402 96 proteinase proteinase NN cord-276616-odmnvv7m 402 97 - - HYPH cord-276616-odmnvv7m 402 98 resistant resistant JJ cord-276616-odmnvv7m 402 99 prion prion NN cord-276616-odmnvv7m 402 100 protein protein NN cord-276616-odmnvv7m 402 101 in in IN cord-276616-odmnvv7m 402 102 humans human NNS cord-276616-odmnvv7m 402 103 and and CC cord-276616-odmnvv7m 402 104 mice mouse NNS cord-276616-odmnvv7m 402 105 with with IN cord-276616-odmnvv7m 402 106 Creutzfeldt Creutzfeldt NNP cord-276616-odmnvv7m 402 107 - - HYPH cord-276616-odmnvv7m 402 108 Jakob Jakob NNP cord-276616-odmnvv7m 402 109 disease disease NN cord-276616-odmnvv7m 402 110 Molecular molecular JJ cord-276616-odmnvv7m 402 111 analysis analysis NN cord-276616-odmnvv7m 402 112 of of IN cord-276616-odmnvv7m 402 113 the the DT cord-276616-odmnvv7m 402 114 envelope envelope NN cord-276616-odmnvv7m 402 115 gene gene NN cord-276616-odmnvv7m 402 116 and and CC cord-276616-odmnvv7m 402 117 long long JJ cord-276616-odmnvv7m 402 118 terminal terminal JJ cord-276616-odmnvv7m 402 119 repeat repeat NN cord-276616-odmnvv7m 402 120 of of IN cord-276616-odmnvv7m 402 121 Friend friend NN cord-276616-odmnvv7m 402 122 mink mink NN cord-276616-odmnvv7m 402 123 cell cell NN cord-276616-odmnvv7m 402 124 focus focus NN cord-276616-odmnvv7m 402 125 - - HYPH cord-276616-odmnvv7m 402 126 inducing induce VBG cord-276616-odmnvv7m 402 127 virus virus NN cord-276616-odmnvv7m 402 128 : : : cord-276616-odmnvv7m 402 129 implications implication NNS cord-276616-odmnvv7m 402 130 for for IN cord-276616-odmnvv7m 402 131 the the DT cord-276616-odmnvv7m 402 132 functions function NNS cord-276616-odmnvv7m 402 133 of of IN cord-276616-odmnvv7m 402 134 these these DT cord-276616-odmnvv7m 402 135 sequences sequence NNS cord-276616-odmnvv7m 402 136 Pathogenesis Pathogenesis NNP cord-276616-odmnvv7m 402 137 of of IN cord-276616-odmnvv7m 402 138 a a DT cord-276616-odmnvv7m 402 139 neurotropic neurotropic NNP cord-276616-odmnvv7m 402 140 murine murine JJ cord-276616-odmnvv7m 402 141 coronavirus coronavirus NN cord-276616-odmnvv7m 402 142 , , , cord-276616-odmnvv7m 402 143 strain strain NN cord-276616-odmnvv7m 402 144 JHM JHM NNP cord-276616-odmnvv7m 402 145 in in IN cord-276616-odmnvv7m 402 146 the the DT cord-276616-odmnvv7m 402 147 central central JJ cord-276616-odmnvv7m 402 148 nervous nervous JJ cord-276616-odmnvv7m 402 149 system system NN cord-276616-odmnvv7m 402 150 of of IN cord-276616-odmnvv7m 402 151 mice mouse NNS cord-276616-odmnvv7m 402 152 Normal normal JJ cord-276616-odmnvv7m 402 153 expression expression NN cord-276616-odmnvv7m 402 154 of of IN cord-276616-odmnvv7m 402 155 polynlorphic polynlorphic JJ cord-276616-odmnvv7m 402 156 endogenous endogenous JJ cord-276616-odmnvv7m 402 157 retroviral retroviral NN cord-276616-odmnvv7m 402 158 RNA rna NN cord-276616-odmnvv7m 402 159 containing contain VBG cord-276616-odmnvv7m 402 160 segments segment NNS cord-276616-odmnvv7m 402 161 identical identical JJ cord-276616-odmnvv7m 402 162 to to IN cord-276616-odmnvv7m 402 163 mink mink NN cord-276616-odmnvv7m 402 164 cell cell NN cord-276616-odmnvv7m 402 165 focus focus NN cord-276616-odmnvv7m 402 166 - - HYPH cord-276616-odmnvv7m 402 167 forming form VBG cord-276616-odmnvv7m 402 168 virus virus NN cord-276616-odmnvv7m 402 169 Infectious infectious JJ cord-276616-odmnvv7m 402 170 peptides peptide NNS cord-276616-odmnvv7m 402 171 : : : cord-276616-odmnvv7m 402 172 postulated postulate VBN cord-276616-odmnvv7m 402 173 mechanisms mechanism NNS cord-276616-odmnvv7m 402 174 of of IN cord-276616-odmnvv7m 402 175 protovirus protovirus NN cord-276616-odmnvv7m 402 176 replication replication NN cord-276616-odmnvv7m 402 177 in in IN cord-276616-odmnvv7m 402 178 scrapie scrapie NN cord-276616-odmnvv7m 402 179 Ultrastructural Ultrastructural NNP cord-276616-odmnvv7m 402 180 neuropathologic neuropathologic JJ cord-276616-odmnvv7m 402 181 features feature NNS cord-276616-odmnvv7m 402 182 of of IN cord-276616-odmnvv7m 402 183 bovine bovine JJ cord-276616-odmnvv7m 402 184 spongiform spongiform JJ cord-276616-odmnvv7m 402 185 encephalopathy encephalopathy NN cord-276616-odmnvv7m 402 186 Neuronal neuronal JJ cord-276616-odmnvv7m 402 187 autophagic autophagic JJ cord-276616-odmnvv7m 402 188 vacuoles vacuole NNS cord-276616-odmnvv7m 402 189 in in IN cord-276616-odmnvv7m 402 190 experimental experimental JJ cord-276616-odmnvv7m 402 191 scrapie scrapie NN cord-276616-odmnvv7m 402 192 and and CC cord-276616-odmnvv7m 402 193 Creutzfeldt Creutzfeldt NNP cord-276616-odmnvv7m 402 194 - - HYPH cord-276616-odmnvv7m 402 195 Jakob Jakob NNP cord-276616-odmnvv7m 402 196 disease disease NN cord-276616-odmnvv7m 402 197 Bovine bovine JJ cord-276616-odmnvv7m 402 198 spongiform spongiform NN cord-276616-odmnvv7m 403 1 encephalopathy encephalopathy NNP cord-276616-odmnvv7m 403 2 Sequence Sequence NNP cord-276616-odmnvv7m 403 3 of of IN cord-276616-odmnvv7m 403 4 mouse mouse NN cord-276616-odmnvv7m 403 5 hepatitis hepatitis NNP cord-276616-odmnvv7m 403 6 virus virus NN cord-276616-odmnvv7m 404 1 A59 A59 NNP cord-276616-odmnvv7m 405 1 mRNA mrna NN cord-276616-odmnvv7m 405 2 : : : cord-276616-odmnvv7m 405 3 2 2 CD cord-276616-odmnvv7m 405 4 . . . cord-276616-odmnvv7m 406 1 Indications indication NNS cord-276616-odmnvv7m 406 2 for for IN cord-276616-odmnvv7m 406 3 RNA RNA NNP cord-276616-odmnvv7m 406 4 recombination recombination NN cord-276616-odmnvv7m 406 5 between between IN cord-276616-odmnvv7m 406 6 corona corona NN cord-276616-odmnvv7m 406 7 - - HYPH cord-276616-odmnvv7m 406 8 viruses virus NNS cord-276616-odmnvv7m 406 9 and and CC cord-276616-odmnvv7m 406 10 influenza influenza NN cord-276616-odmnvv7m 406 11 C c NN cord-276616-odmnvv7m 406 12 virus virus NN cord-276616-odmnvv7m 407 1 H-2-associated H-2-associated NNP cord-276616-odmnvv7m 407 2 and and CC cord-276616-odmnvv7m 407 3 background background NN cord-276616-odmnvv7m 407 4 genes gene NNS cord-276616-odmnvv7m 407 5 influence influence VBP cord-276616-odmnvv7m 407 6 the the DT cord-276616-odmnvv7m 407 7 development development NN cord-276616-odmnvv7m 407 8 of of IN cord-276616-odmnvv7m 407 9 a a DT cord-276616-odmnvv7m 407 10 routine routine JJ cord-276616-odmnvv7m 407 11 retrovirus retrovirus NN cord-276616-odmnvv7m 407 12 - - HYPH cord-276616-odmnvv7m 407 13 induced induce VBN cord-276616-odmnvv7m 407 14 immunodeficiency immunodeficiency NN cord-276616-odmnvv7m 407 15 syndrome syndrome NN cord-276616-odmnvv7m 407 16 Observations Observations NNP cord-276616-odmnvv7m 407 17 on on IN cord-276616-odmnvv7m 407 18 Creutzfeldt Creutzfeldt NNP cord-276616-odmnvv7m 407 19 - - HYPH cord-276616-odmnvv7m 407 20 Jakob Jakob NNP cord-276616-odmnvv7m 407 21 disease disease NN cord-276616-odmnvv7m 407 22 propagated propagate VBD cord-276616-odmnvv7m 407 23 in in IN cord-276616-odmnvv7m 407 24 small small JJ cord-276616-odmnvv7m 407 25 rodents rodent NNS cord-276616-odmnvv7m 407 26 Search search VB cord-276616-odmnvv7m 407 27 for for IN cord-276616-odmnvv7m 407 28 a a DT cord-276616-odmnvv7m 407 29 transmissible transmissible JJ cord-276616-odmnvv7m 407 30 agent agent NN cord-276616-odmnvv7m 407 31 in in IN cord-276616-odmnvv7m 407 32 Alzheimer Alzheimer NNP cord-276616-odmnvv7m 407 33 's 's POS cord-276616-odmnvv7m 407 34 disease disease NN cord-276616-odmnvv7m 407 35 : : : cord-276616-odmnvv7m 407 36 studies study NNS cord-276616-odmnvv7m 407 37 of of IN cord-276616-odmnvv7m 407 38 human human NNP cord-276616-odmnvv7m 407 39 buffy buffy NNP cord-276616-odmnvv7m 407 40 coat coat NNP cord-276616-odmnvv7m 408 1 The the DT cord-276616-odmnvv7m 408 2 subacute subacute JJ cord-276616-odmnvv7m 408 3 spongiform spongiform JJ cord-276616-odmnvv7m 408 4 encephalopathies encephalopathy NNS cord-276616-odmnvv7m 408 5 Physical Physical NNP cord-276616-odmnvv7m 408 6 and and CC cord-276616-odmnvv7m 408 7 chemical chemical JJ cord-276616-odmnvv7m 408 8 properties property NNS cord-276616-odmnvv7m 408 9 of of IN cord-276616-odmnvv7m 408 10 the the DT cord-276616-odmnvv7m 408 11 transmissible transmissible JJ cord-276616-odmnvv7m 408 12 mink mink NN cord-276616-odmnvv7m 408 13 encephalopathy encephalopathy NN cord-276616-odmnvv7m 408 14 agent agent NN cord-276616-odmnvv7m 408 15 Equilibrium Equilibrium NNP cord-276616-odmnvv7m 408 16 density density NN cord-276616-odmnvv7m 408 17 gradient gradient NN cord-276616-odmnvv7m 408 18 centrifugation centrifugation NN cord-276616-odmnvv7m 408 19 of of IN cord-276616-odmnvv7m 408 20 the the DT cord-276616-odmnvv7m 408 21 scrapie scrapie NN cord-276616-odmnvv7m 408 22 agent agent NN cord-276616-odmnvv7m 408 23 in in IN cord-276616-odmnvv7m 408 24 Nycodenz Nycodenz NNP cord-276616-odmnvv7m 408 25 Epidemiological Epidemiological NNP cord-276616-odmnvv7m 408 26 and and CC cord-276616-odmnvv7m 408 27 experimental experimental JJ cord-276616-odmnvv7m 408 28 studies study NNS cord-276616-odmnvv7m 408 29 on on IN cord-276616-odmnvv7m 408 30 a a DT cord-276616-odmnvv7m 408 31 new new JJ cord-276616-odmnvv7m 408 32 incident incident NN cord-276616-odmnvv7m 408 33 of of IN cord-276616-odmnvv7m 408 34 transmissible transmissible JJ cord-276616-odmnvv7m 408 35 mink mink NN cord-276616-odmnvv7m 408 36 encephalopathy encephalopathy NN cord-276616-odmnvv7m 408 37 Bovine bovine JJ cord-276616-odmnvv7m 408 38 spongiform spongiform JJ cord-276616-odmnvv7m 408 39 encephalopathy encephalopathy NN cord-276616-odmnvv7m 408 40 Abnormal abnormal JJ cord-276616-odmnvv7m 408 41 fibrils fibril NNS cord-276616-odmnvv7m 408 42 from from IN cord-276616-odmnvv7m 408 43 scrapie scrapie NN cord-276616-odmnvv7m 408 44 - - HYPH cord-276616-odmnvv7m 408 45 infected infect VBN cord-276616-odmnvv7m 408 46 brain brain NN cord-276616-odmnvv7m 408 47 Glycosidases Glycosidases NNP cord-276616-odmnvv7m 408 48 in in IN cord-276616-odmnvv7m 408 49 normal normal JJ cord-276616-odmnvv7m 408 50 and and CC cord-276616-odmnvv7m 408 51 scrapie scrapie JJ cord-276616-odmnvv7m 408 52 mouse mouse NN cord-276616-odmnvv7m 408 53 brain brain NN cord-276616-odmnvv7m 408 54 Ground Ground NNP cord-276616-odmnvv7m 408 55 squirrel squirrel NN cord-276616-odmnvv7m 408 56 hepatitis hepatitis NN cord-276616-odmnvv7m 408 57 virus virus NN cord-276616-odmnvv7m 408 58 ( ( -LRB- cord-276616-odmnvv7m 408 59 GSHV GSHV NNP cord-276616-odmnvv7m 408 60 ) ) -RRB- cord-276616-odmnvv7m 408 61 and and CC cord-276616-odmnvv7m 408 62 hepatocellular hepatocellular JJ cord-276616-odmnvv7m 408 63 carcinoma carcinoma NN cord-276616-odmnvv7m 408 64 in in IN cord-276616-odmnvv7m 408 65 the the DT cord-276616-odmnvv7m 408 66 Canadian Canadian NNP cord-276616-odmnvv7m 408 67 Richardson Richardson NNP cord-276616-odmnvv7m 408 68 ground ground NN cord-276616-odmnvv7m 408 69 squirrel squirrel NN cord-276616-odmnvv7m 408 70 ( ( -LRB- cord-276616-odmnvv7m 408 71 Spermophilus spermophilus JJ cord-276616-odmnvv7m 408 72 richardsonii richardsonii NN cord-276616-odmnvv7m 408 73 ) ) -RRB- cord-276616-odmnvv7m 409 1 The the DT cord-276616-odmnvv7m 409 2 response response NN cord-276616-odmnvv7m 409 3 in in IN cord-276616-odmnvv7m 409 4 mice mouse NNS cord-276616-odmnvv7m 409 5 to to TO cord-276616-odmnvv7m 409 6 heat heat VB cord-276616-odmnvv7m 409 7 treated treat VBN cord-276616-odmnvv7m 409 8 scrapie scrapie NN cord-276616-odmnvv7m 409 9 agent agent NN cord-276616-odmnvv7m 409 10 Assay Assay NNP cord-276616-odmnvv7m 409 11 of of IN cord-276616-odmnvv7m 409 12 ethane ethane NN cord-276616-odmnvv7m 409 13 and and CC cord-276616-odmnvv7m 409 14 pentane pentane NNS cord-276616-odmnvv7m 409 15 from from IN cord-276616-odmnvv7m 409 16 isolated isolated JJ cord-276616-odmnvv7m 409 17 organs organ NNS cord-276616-odmnvv7m 409 18 and and CC cord-276616-odmnvv7m 409 19 cells cell NNS cord-276616-odmnvv7m 409 20 Basis basis NN cord-276616-odmnvv7m 409 21 of of IN cord-276616-odmnvv7m 409 22 hepatitis hepatitis NNP cord-276616-odmnvv7m 409 23 delta delta NNP cord-276616-odmnvv7m 409 24 virus virus NN cord-276616-odmnvv7m 409 25 disease disease NN cord-276616-odmnvv7m 409 26 ? ? . cord-276616-odmnvv7m 410 1 Feline feline JJ cord-276616-odmnvv7m 410 2 leukaemia leukaemia NN cord-276616-odmnvv7m 410 3 virus virus NN cord-276616-odmnvv7m 410 4 : : : cord-276616-odmnvv7m 410 5 generation generation NN cord-276616-odmnvv7m 410 6 of of IN cord-276616-odmnvv7m 410 7 pathogenic pathogenic JJ cord-276616-odmnvv7m 410 8 and and CC cord-276616-odmnvv7m 410 9 oncogenic oncogenic JJ cord-276616-odmnvv7m 410 10 variants variant NNS cord-276616-odmnvv7m 411 1 The the DT cord-276616-odmnvv7m 411 2 envelope envelope NN cord-276616-odmnvv7m 411 3 gene gene NN cord-276616-odmnvv7m 411 4 and and CC cord-276616-odmnvv7m 411 5 long long JJ cord-276616-odmnvv7m 411 6 terminal terminal NN cord-276616-odmnvv7m 411 7 repeat repeat NN cord-276616-odmnvv7m 411 8 sequences sequence NNS cord-276616-odmnvv7m 411 9 contribute contribute VBP cord-276616-odmnvv7m 411 10 to to IN cord-276616-odmnvv7m 411 11 the the DT cord-276616-odmnvv7m 411 12 pathogenic pathogenic JJ cord-276616-odmnvv7m 411 13 phenotype phenotype NN cord-276616-odmnvv7m 411 14 of of IN cord-276616-odmnvv7m 411 15 helper helper NN cord-276616-odmnvv7m 411 16 - - HYPH cord-276616-odmnvv7m 411 17 independent independent JJ cord-276616-odmnvv7m 411 18 Friend friend NN cord-276616-odmnvv7m 411 19 viruses virus NNS cord-276616-odmnvv7m 412 1 Homozygous Homozygous NNP cord-276616-odmnvv7m 413 1 prion prion NN cord-276616-odmnvv7m 413 2 protein protein NN cord-276616-odmnvv7m 413 3 genotype genotype NN cord-276616-odmnvv7m 413 4 predisposes predispose VBZ cord-276616-odmnvv7m 413 5 to to IN cord-276616-odmnvv7m 413 6 sporadic sporadic JJ cord-276616-odmnvv7m 413 7 Creutzfeldt Creutzfeldt NNP cord-276616-odmnvv7m 413 8 - - HYPH cord-276616-odmnvv7m 413 9 Jakob Jakob NNP cord-276616-odmnvv7m 413 10 disease disease NN cord-276616-odmnvv7m 413 11 Spongy Spongy NNP cord-276616-odmnvv7m 413 12 brain brain NN cord-276616-odmnvv7m 413 13 : : : cord-276616-odmnvv7m 413 14 the the DT cord-276616-odmnvv7m 413 15 mystery mystery NN cord-276616-odmnvv7m 413 16 of of IN cord-276616-odmnvv7m 413 17 mad mad JJ cord-276616-odmnvv7m 413 18 cow cow NN cord-276616-odmnvv7m 413 19 disease disease NN cord-276616-odmnvv7m 413 20 . . . cord-276616-odmnvv7m 414 1 Toronto Toronto NNP cord-276616-odmnvv7m 414 2 Globe Globe NNP cord-276616-odmnvv7m 414 3 and and CC cord-276616-odmnvv7m 414 4 Mail Mail NNP cord-276616-odmnvv7m 414 5 Novel Novel NNP cord-276616-odmnvv7m 414 6 proteinaceous proteinaceous JJ cord-276616-odmnvv7m 414 7 infectious infectious JJ cord-276616-odmnvv7m 414 8 particles particle NNS cord-276616-odmnvv7m 414 9 cause cause VBP cord-276616-odmnvv7m 414 10 scrapie scrapie NN cord-276616-odmnvv7m 414 11 Pathogenesis Pathogenesis NNP cord-276616-odmnvv7m 414 12 , , , cord-276616-odmnvv7m 414 13 Immunology Immunology NNP cord-276616-odmnvv7m 414 14 , , , cord-276616-odmnvv7m 414 15 Virology Virology NNP cord-276616-odmnvv7m 414 16 and and CC cord-276616-odmnvv7m 414 17 Molecular Molecular NNP cord-276616-odmnvv7m 414 18 Biology Biology NNP cord-276616-odmnvv7m 414 19 of of IN cord-276616-odmnvv7m 414 20 the the DT cord-276616-odmnvv7m 414 21 Spongiform Spongiform NNP cord-276616-odmnvv7m 414 22 Ence_phalopathies Ence_phalopathies NNPS cord-276616-odmnvv7m 414 23 Generation Generation NNP cord-276616-odmnvv7m 414 24 of of IN cord-276616-odmnvv7m 414 25 AKR AKR NNP cord-276616-odmnvv7m 414 26 mink mink NN cord-276616-odmnvv7m 414 27 cell cell NN cord-276616-odmnvv7m 414 28 focus focus NN cord-276616-odmnvv7m 414 29 - - HYPH cord-276616-odmnvv7m 414 30 forming form VBG cord-276616-odmnvv7m 414 31 xenotropic xenotropic NN cord-276616-odmnvv7m 414 32 - - HYPH cord-276616-odmnvv7m 414 33 like like JJ cord-276616-odmnvv7m 414 34 provirns provirn NNS cord-276616-odmnvv7m 414 35 provides provide VBZ cord-276616-odmnvv7m 414 36 recombinant recombinant JJ cord-276616-odmnvv7m 414 37 long long JJ cord-276616-odmnvv7m 414 38 terminal terminal NN cord-276616-odmnvv7m 414 39 repeat repeat NN cord-276616-odmnvv7m 414 40 sequences sequence NNS cord-276616-odmnvv7m 415 1 Analyses analysis NNS cord-276616-odmnvv7m 415 2 of of IN cord-276616-odmnvv7m 415 3 frequency frequency NN cord-276616-odmnvv7m 415 4 of of IN cord-276616-odmnvv7m 415 5 infection infection NN cord-276616-odmnvv7m 415 6 , , , cord-276616-odmnvv7m 415 7 specific specific JJ cord-276616-odmnvv7m 415 8 infectivity infectivity NN cord-276616-odmnvv7m 415 9 , , , cord-276616-odmnvv7m 415 10 and and CC cord-276616-odmnvv7m 415 11 prion prion NN cord-276616-odmnvv7m 415 12 protein protein NN cord-276616-odmnvv7m 415 13 biosynthesis biosynthesis NN cord-276616-odmnvv7m 415 14 in in IN cord-276616-odmnvv7m 415 15 scrapie scrapie NN cord-276616-odmnvv7m 415 16 - - HYPH cord-276616-odmnvv7m 415 17 infected infect VBN cord-276616-odmnvv7m 415 18 neuroblastoma neuroblastoma NN cord-276616-odmnvv7m 415 19 cell cell NN cord-276616-odmnvv7m 415 20 clones clone NNS cord-276616-odmnvv7m 415 21 Immune immune VBP cord-276616-odmnvv7m 415 22 abnormalities abnormality NNS cord-276616-odmnvv7m 415 23 in in IN cord-276616-odmnvv7m 415 24 avian avian JJ cord-276616-odmnvv7m 415 25 erythroblastosis erythroblastosis NNP cord-276616-odmnvv7m 415 26 virns virns NNP cord-276616-odmnvv7m 415 27 - - HYPH cord-276616-odmnvv7m 415 28 infected infect VBN cord-276616-odmnvv7m 415 29 chickens chicken NNS cord-276616-odmnvv7m 415 30 HIV HIV NNP cord-276616-odmnvv7m 415 31 infection infection NN cord-276616-odmnvv7m 415 32 : : : cord-276616-odmnvv7m 415 33 the the DT cord-276616-odmnvv7m 415 34 clinical clinical JJ cord-276616-odmnvv7m 415 35 picture picture NN cord-276616-odmnvv7m 415 36 Production production NN cord-276616-odmnvv7m 415 37 of of IN cord-276616-odmnvv7m 415 38 unique unique JJ cord-276616-odmnvv7m 415 39 C c NN cord-276616-odmnvv7m 415 40 - - HYPH cord-276616-odmnvv7m 415 41 type type NN cord-276616-odmnvv7m 415 42 viruses virus NNS cord-276616-odmnvv7m 415 43 by by IN cord-276616-odmnvv7m 415 44 chicken chicken NN cord-276616-odmnvv7m 415 45 cells cell NNS cord-276616-odmnvv7m 415 46 grown grow VBN cord-276616-odmnvv7m 415 47 in in IN cord-276616-odmnvv7m 415 48 bromodeoxyuridine bromodeoxyuridine NN cord-276616-odmnvv7m 415 49 Experimental experimental JJ cord-276616-odmnvv7m 415 50 infection infection NN cord-276616-odmnvv7m 415 51 of of IN cord-276616-odmnvv7m 415 52 mink mink NN cord-276616-odmnvv7m 415 53 with with IN cord-276616-odmnvv7m 415 54 bovine bovine JJ cord-276616-odmnvv7m 415 55 spongiform spongiform JJ cord-276616-odmnvv7m 415 56 encephalopathy encephalopathy NN cord-276616-odmnvv7m 416 1 The the DT cord-276616-odmnvv7m 416 2 scrapie scrapie NN cord-276616-odmnvv7m 416 3 agent agent NN cord-276616-odmnvv7m 416 4 : : : cord-276616-odmnvv7m 416 5 ' ' '' cord-276616-odmnvv7m 417 1 A a DT cord-276616-odmnvv7m 417 2 virus virus NN cord-276616-odmnvv7m 417 3 by by IN cord-276616-odmnvv7m 417 4 any any DT cord-276616-odmnvv7m 417 5 other other JJ cord-276616-odmnvv7m 417 6 name name NN cord-276616-odmnvv7m 417 7 Detection detection NN cord-276616-odmnvv7m 417 8 of of IN cord-276616-odmnvv7m 417 9 scrapie scrapie NN cord-276616-odmnvv7m 417 10 - - HYPH cord-276616-odmnvv7m 417 11 associated associate VBN cord-276616-odmnvv7m 417 12 fibril fibril NN cord-276616-odmnvv7m 417 13 proteins protein NNS cord-276616-odmnvv7m 417 14 using use VBG cord-276616-odmnvv7m 417 15 anti anti JJ cord-276616-odmnvv7m 417 16 - - JJ cord-276616-odmnvv7m 417 17 SAF SAF NNP cord-276616-odmnvv7m 417 18 antibody antibody NN cord-276616-odmnvv7m 417 19 in in IN cord-276616-odmnvv7m 417 20 non non JJ cord-276616-odmnvv7m 417 21 - - JJ cord-276616-odmnvv7m 417 22 purified purified JJ cord-276616-odmnvv7m 417 23 tissue tissue NN cord-276616-odmnvv7m 417 24 preparations preparation NNS cord-276616-odmnvv7m 418 1 Spongiform spongiform JJ cord-276616-odmnvv7m 418 2 encephalopathy encephalopathy NN cord-276616-odmnvv7m 418 3 in in IN cord-276616-odmnvv7m 418 4 sheep sheep NN cord-276616-odmnvv7m 418 5 scrapie scrapie NN cord-276616-odmnvv7m 418 6 : : : cord-276616-odmnvv7m 419 1 electron electron NN cord-276616-odmnvv7m 419 2 microscopic microscopic JJ cord-276616-odmnvv7m 419 3 observations observation NNS cord-276616-odmnvv7m 419 4 Bovine bovine JJ cord-276616-odmnvv7m 419 5 spongiform spongiform JJ cord-276616-odmnvv7m 419 6 encephalopathy encephalopathy NN cord-276616-odmnvv7m 419 7 : : : cord-276616-odmnvv7m 419 8 detection detection NN cord-276616-odmnvv7m 419 9 and and CC cord-276616-odmnvv7m 419 10 quantitation quantitation NN cord-276616-odmnvv7m 419 11 of of IN cord-276616-odmnvv7m 419 12 fibrils fibril NNS cord-276616-odmnvv7m 419 13 , , , cord-276616-odmnvv7m 419 14 fibril fibril NNP cord-276616-odmnvv7m 419 15 protein protein NN cord-276616-odmnvv7m 419 16 ( ( -LRB- cord-276616-odmnvv7m 419 17 PrP prp NN cord-276616-odmnvv7m 419 18 ) ) -RRB- cord-276616-odmnvv7m 419 19 and and CC cord-276616-odmnvv7m 419 20 vacuolation vacuolation NN cord-276616-odmnvv7m 419 21 in in IN cord-276616-odmnvv7m 419 22 brain brain NN cord-276616-odmnvv7m 419 23 Transgenic transgenic JJ cord-276616-odmnvv7m 419 24 mice mouse NNS cord-276616-odmnvv7m 419 25 expressing express VBG cord-276616-odmnvv7m 419 26 hamster hamster NN cord-276616-odmnvv7m 419 27 priori priori FW cord-276616-odmnvv7m 419 28 protein protein NN cord-276616-odmnvv7m 419 29 produce produce VBP cord-276616-odmnvv7m 419 30 species specie NNS cord-276616-odmnvv7m 419 31 - - HYPH cord-276616-odmnvv7m 419 32 specific specific JJ cord-276616-odmnvv7m 419 33 scrapie scrapie NN cord-276616-odmnvv7m 419 34 infectivity infectivity NN cord-276616-odmnvv7m 419 35 and and CC cord-276616-odmnvv7m 419 36 amyloid amyloid NN cord-276616-odmnvv7m 419 37 plaques plaque NNS cord-276616-odmnvv7m 419 38 Bovine bovine JJ cord-276616-odmnvv7m 419 39 spongiform spongiform JJ cord-276616-odmnvv7m 419 40 encephalopathy encephalopathy NN cord-276616-odmnvv7m 419 41 in in IN cord-276616-odmnvv7m 419 42 an an DT cord-276616-odmnvv7m 419 43 adult adult JJ cord-276616-odmnvv7m 419 44 British british JJ cord-276616-odmnvv7m 419 45 Friesian friesian JJ cord-276616-odmnvv7m 419 46 cow cow NN cord-276616-odmnvv7m 419 47 BSE BSE NNP cord-276616-odmnvv7m 419 48 and and CC cord-276616-odmnvv7m 419 49 potential potential JJ cord-276616-odmnvv7m 419 50 risk risk NN cord-276616-odmnvv7m 419 51 to to TO cord-276616-odmnvv7m 419 52 slaughtermen slaughtermen VBZ cord-276616-odmnvv7m 419 53 Calorie Calorie NNP cord-276616-odmnvv7m 419 54 restriction restriction NN cord-276616-odmnvv7m 419 55 suppresses suppress VBZ cord-276616-odmnvv7m 419 56 subgenomic subgenomic NNP cord-276616-odmnvv7m 419 57 mink mink NNP cord-276616-odmnvv7m 419 58 cytopathic cytopathic NNP cord-276616-odmnvv7m 419 59 focus focus NN cord-276616-odmnvv7m 419 60 - - HYPH cord-276616-odmnvv7m 419 61 forming form VBG cord-276616-odmnvv7m 419 62 routine routine JJ cord-276616-odmnvv7m 419 63 leukemia leukemia NN cord-276616-odmnvv7m 419 64 virus virus NN cord-276616-odmnvv7m 419 65 transcription transcription NN cord-276616-odmnvv7m 419 66 and and CC cord-276616-odmnvv7m 419 67 frequency frequency NN cord-276616-odmnvv7m 419 68 of of IN cord-276616-odmnvv7m 419 69 genomic genomic JJ cord-276616-odmnvv7m 419 70 expression expression NN cord-276616-odmnvv7m 419 71 while while IN cord-276616-odmnvv7m 419 72 impairing impair VBG cord-276616-odmnvv7m 419 73 lymphoma lymphoma NN cord-276616-odmnvv7m 419 74 formation formation NN cord-276616-odmnvv7m 419 75 Characterization characterization NN cord-276616-odmnvv7m 419 76 of of IN cord-276616-odmnvv7m 419 77 the the DT cord-276616-odmnvv7m 419 78 scrapie scrapie NN cord-276616-odmnvv7m 419 79 agent agent NN cord-276616-odmnvv7m 419 80 isolated isolate VBN cord-276616-odmnvv7m 419 81 from from IN cord-276616-odmnvv7m 419 82 sheep sheep NNS cord-276616-odmnvv7m 419 83 in in IN cord-276616-odmnvv7m 419 84 Japan Japan NNP cord-276616-odmnvv7m 419 85 Differential Differential NNP cord-276616-odmnvv7m 419 86 glycosylation glycosylation NN cord-276616-odmnvv7m 419 87 of of IN cord-276616-odmnvv7m 419 88 the the DT cord-276616-odmnvv7m 419 89 protein protein NN cord-276616-odmnvv7m 419 90 ( ( -LRB- cord-276616-odmnvv7m 419 91 PrP prp NN cord-276616-odmnvv7m 419 92 ) ) -RRB- cord-276616-odmnvv7m 419 93 forming form VBG cord-276616-odmnvv7m 419 94 scrapie scrapie NN cord-276616-odmnvv7m 419 95 associated associate VBN cord-276616-odmnvv7m 419 96 fibrils fibril NNS cord-276616-odmnvv7m 420 1 The the DT cord-276616-odmnvv7m 420 2 immunology immunology NN cord-276616-odmnvv7m 420 3 of of IN cord-276616-odmnvv7m 420 4 scrapie scrapie NN cord-276616-odmnvv7m 420 5 A a DT cord-276616-odmnvv7m 420 6 transmissible transmissible JJ cord-276616-odmnvv7m 420 7 variant variant NN cord-276616-odmnvv7m 420 8 of of IN cord-276616-odmnvv7m 420 9 Creutzfeldt Creutzfeldt NNP cord-276616-odmnvv7m 420 10 - - HYPH cord-276616-odmnvv7m 420 11 Jakob Jakob NNP cord-276616-odmnvv7m 420 12 disease disease NN cord-276616-odmnvv7m 420 13 with with IN cord-276616-odmnvv7m 420 14 Kuru Kuru NNP cord-276616-odmnvv7m 420 15 plaques plaque NNS cord-276616-odmnvv7m 420 16 Bovine bovine JJ cord-276616-odmnvv7m 420 17 spongiform spongiform JJ cord-276616-odmnvv7m 420 18 encephalopathy encephalopathy NN cord-276616-odmnvv7m 420 19 and and CC cord-276616-odmnvv7m 420 20 human human JJ cord-276616-odmnvv7m 420 21 health health NN cord-276616-odmnvv7m 420 22 Hepatitis Hepatitis NNP cord-276616-odmnvv7m 420 23 B B NNP cord-276616-odmnvv7m 420 24 virus virus NN cord-276616-odmnvv7m 421 1 The the DT cord-276616-odmnvv7m 421 2 prion prion NN cord-276616-odmnvv7m 421 3 's 's POS cord-276616-odmnvv7m 421 4 progress progress NN cord-276616-odmnvv7m 421 5 A a DT cord-276616-odmnvv7m 421 6 ' ' `` cord-276616-odmnvv7m 421 7 unified unified JJ cord-276616-odmnvv7m 421 8 theory theory NN cord-276616-odmnvv7m 421 9 ' ' '' cord-276616-odmnvv7m 421 10 of of IN cord-276616-odmnvv7m 421 11 priori priori JJ cord-276616-odmnvv7m 421 12 propagation propagation NN cord-276616-odmnvv7m 421 13 Recently recently RB cord-276616-odmnvv7m 421 14 described describe VBD cord-276616-odmnvv7m 421 15 scrapie scrapie NN cord-276616-odmnvv7m 421 16 - - HYPH cord-276616-odmnvv7m 421 17 like like JJ cord-276616-odmnvv7m 421 18 encephalopathies encephalopathy NNS cord-276616-odmnvv7m 421 19 of of IN cord-276616-odmnvv7m 421 20 animals animal NNS cord-276616-odmnvv7m 421 21 : : : cord-276616-odmnvv7m 422 1 case case NN cord-276616-odmnvv7m 422 2 definitions definition NNS cord-276616-odmnvv7m 423 1 The the DT cord-276616-odmnvv7m 423 2 distribution distribution NN cord-276616-odmnvv7m 423 3 of of IN cord-276616-odmnvv7m 423 4 neuronal neuronal JJ cord-276616-odmnvv7m 423 5 vacuolation vacuolation NN cord-276616-odmnvv7m 423 6 in in IN cord-276616-odmnvv7m 423 7 bovine bovine JJ cord-276616-odmnvv7m 423 8 spongiform spongiform JJ cord-276616-odmnvv7m 423 9 encephalopathy encephalopathy NN cord-276616-odmnvv7m 423 10 ( ( -LRB- cord-276616-odmnvv7m 423 11 BSE BSE NNP cord-276616-odmnvv7m 423 12 ) ) -RRB- cord-276616-odmnvv7m 423 13 is be VBZ cord-276616-odmnvv7m 423 14 constant constant JJ cord-276616-odmnvv7m 423 15 A a DT cord-276616-odmnvv7m 423 16 novel novel JJ cord-276616-odmnvv7m 423 17 progressive progressive JJ cord-276616-odmnvv7m 423 18 spongiform spongiform JJ cord-276616-odmnvv7m 423 19 encephalopathy encephalopathy NN cord-276616-odmnvv7m 423 20 in in IN cord-276616-odmnvv7m 423 21 cattle cattle NNS cord-276616-odmnvv7m 423 22 Bovine bovine JJ cord-276616-odmnvv7m 423 23 spongiform spongiform JJ cord-276616-odmnvv7m 423 24 encephalopathy encephalopathy NN cord-276616-odmnvv7m 423 25 : : : cord-276616-odmnvv7m 423 26 diagnostic diagnostic JJ cord-276616-odmnvv7m 423 27 significance significance NN cord-276616-odmnvv7m 423 28 of of IN cord-276616-odmnvv7m 423 29 vacuolar vacuolar JJ cord-276616-odmnvv7m 423 30 changes change NNS cord-276616-odmnvv7m 423 31 in in IN cord-276616-odmnvv7m 423 32 sgleeted sgleeted JJ cord-276616-odmnvv7m 423 33 nuclei nucleus NNS cord-276616-odmnvv7m 423 34 of of IN cord-276616-odmnvv7m 423 35 the the DT cord-276616-odmnvv7m 423 36 medulla medulla NN cord-276616-odmnvv7m 423 37 oblongata oblongata NN cord-276616-odmnvv7m 423 38 Bovine bovine JJ cord-276616-odmnvv7m 423 39 spongiform spongiform JJ cord-276616-odmnvv7m 423 40 encephalopathy encephalopathy NN cord-276616-odmnvv7m 423 41 : : : cord-276616-odmnvv7m 423 42 observations observation NNS cord-276616-odmnvv7m 423 43 on on IN cord-276616-odmnvv7m 423 44 the the DT cord-276616-odmnvv7m 423 45 incidence incidence NN cord-276616-odmnvv7m 423 46 during during IN cord-276616-odmnvv7m 423 47 1992 1992 CD cord-276616-odmnvv7m 423 48 Bovine bovine JJ cord-276616-odmnvv7m 423 49 spongiform spongiform JJ cord-276616-odmnvv7m 423 50 encephalopathy encephalopathy NN cord-276616-odmnvv7m 423 51 : : : cord-276616-odmnvv7m 423 52 epidemiological epidemiological JJ cord-276616-odmnvv7m 423 53 studies study NNS cord-276616-odmnvv7m 423 54 on on IN cord-276616-odmnvv7m 423 55 the the DT cord-276616-odmnvv7m 423 56 origin origin NN cord-276616-odmnvv7m 423 57 Bovine bovine JJ cord-276616-odmnvv7m 423 58 spongiform spongiform JJ cord-276616-odmnvv7m 423 59 encephalopathy encephalopathy NN cord-276616-odmnvv7m 423 60 : : : cord-276616-odmnvv7m 423 61 case case NN cord-276616-odmnvv7m 423 62 - - HYPH cord-276616-odmnvv7m 423 63 control control NN cord-276616-odmnvv7m 423 64 studies study NNS cord-276616-odmnvv7m 423 65 of of IN cord-276616-odmnvv7m 423 66 calf calf NN cord-276616-odmnvv7m 423 67 feeding feeding NN cord-276616-odmnvv7m 423 68 practices practice NNS cord-276616-odmnvv7m 423 69 and and CC cord-276616-odmnvv7m 423 70 meat meat NN cord-276616-odmnvv7m 423 71 and and CC cord-276616-odmnvv7m 423 72 bone bone NN cord-276616-odmnvv7m 423 73 meal meal NN cord-276616-odmnvv7m 423 74 inclusion inclusion NN cord-276616-odmnvv7m 423 75 in in IN cord-276616-odmnvv7m 423 76 proprietary proprietary JJ cord-276616-odmnvv7m 423 77 concentrates concentrate VBZ cord-276616-odmnvv7m 423 78 Bovine bovine JJ cord-276616-odmnvv7m 423 79 spongiform spongiform JJ cord-276616-odmnvv7m 423 80 encephalopathy encephalopathy NN cord-276616-odmnvv7m 423 81 and and CC cord-276616-odmnvv7m 423 82 risk risk NN cord-276616-odmnvv7m 423 83 to to TO cord-276616-odmnvv7m 423 84 health health NN cord-276616-odmnvv7m 423 85 Chronic chronic NN cord-276616-odmnvv7m 423 86 wasting waste VBG cord-276616-odmnvv7m 423 87 disease disease NN cord-276616-odmnvv7m 423 88 of of IN cord-276616-odmnvv7m 423 89 captive captive JJ cord-276616-odmnvv7m 423 90 mule mule JJ cord-276616-odmnvv7m 423 91 deer deer NN cord-276616-odmnvv7m 423 92 : : : cord-276616-odmnvv7m 423 93 a a DT cord-276616-odmnvv7m 423 94 spongiform spongiform JJ cord-276616-odmnvv7m 423 95 encephalopathy encephalopathy NN cord-276616-odmnvv7m 424 1 Spongiform spongiform JJ cord-276616-odmnvv7m 424 2 encephalopathy encephalopathy NN cord-276616-odmnvv7m 424 3 of of IN cord-276616-odmnvv7m 424 4 Rocky Rocky NNP cord-276616-odmnvv7m 424 5 Mountain Mountain NNP cord-276616-odmnvv7m 424 6 elk elk NNP cord-276616-odmnvv7m 424 7 Spongiform spongiform JJ cord-276616-odmnvv7m 424 8 encephalopathy encephalopathy NN cord-276616-odmnvv7m 424 9 in in IN cord-276616-odmnvv7m 424 10 a a DT cord-276616-odmnvv7m 424 11 captive captive JJ cord-276616-odmnvv7m 424 12 puma puma NN cord-276616-odmnvv7m 424 13 ( ( -LRB- cord-276616-odmnvv7m 424 14 Felis Felis NNP cord-276616-odmnvv7m 424 15 concolor concolor NN cord-276616-odmnvv7m 424 16 ) ) -RRB- cord-276616-odmnvv7m 425 1 Embryo embryo NN cord-276616-odmnvv7m 425 2 transfer transfer NN cord-276616-odmnvv7m 425 3 , , , cord-276616-odmnvv7m 425 4 semen semen NN cord-276616-odmnvv7m 425 5 , , , cord-276616-odmnvv7m 425 6 scrapie scrapie NN cord-276616-odmnvv7m 425 7 Amphotericin Amphotericin NNP cord-276616-odmnvv7m 425 8 B B NNP cord-276616-odmnvv7m 425 9 treatment treatment NN cord-276616-odmnvv7m 425 10 dissociates dissociate VBZ cord-276616-odmnvv7m 425 11 in in IN cord-276616-odmnvv7m 425 12 vitro vitro FW cord-276616-odmnvv7m 425 13 replication replication NN cord-276616-odmnvv7m 425 14 of of IN cord-276616-odmnvv7m 425 15 the the DT cord-276616-odmnvv7m 425 16 scrapie scrapie NN cord-276616-odmnvv7m 425 17 agent agent NN cord-276616-odmnvv7m 425 18 from from IN cord-276616-odmnvv7m 425 19 PrP PrP NNP cord-276616-odmnvv7m 425 20 accumulation accumulation NN cord-276616-odmnvv7m 425 21 I -PRON- PRP cord-276616-odmnvv7m 425 22 am be VBP cord-276616-odmnvv7m 425 23 deeply deeply RB cord-276616-odmnvv7m 425 24 appreciative appreciative JJ cord-276616-odmnvv7m 425 25 of of IN cord-276616-odmnvv7m 425 26 the the DT cord-276616-odmnvv7m 425 27 help help NN cord-276616-odmnvv7m 425 28 given give VBN cord-276616-odmnvv7m 425 29 me -PRON- PRP cord-276616-odmnvv7m 425 30 by by IN cord-276616-odmnvv7m 425 31 Dr Dr NNP cord-276616-odmnvv7m 425 32 H.J. H.J. NNP cord-276616-odmnvv7m 425 33 Cho Cho NNP cord-276616-odmnvv7m 425 34 and and CC cord-276616-odmnvv7m 425 35 Dr Dr NNP cord-276616-odmnvv7m 425 36 R.M. R.M. NNP cord-276616-odmnvv7m 425 37 Barlow Barlow NNP cord-276616-odmnvv7m 425 38 in in IN cord-276616-odmnvv7m 425 39 the the DT cord-276616-odmnvv7m 425 40 preparation preparation NN cord-276616-odmnvv7m 425 41 of of IN cord-276616-odmnvv7m 425 42 this this DT cord-276616-odmnvv7m 425 43 manuscript manuscript NN cord-276616-odmnvv7m 425 44 . . . cord-276616-odmnvv7m 426 1 Lisa Lisa NNP cord-276616-odmnvv7m 426 2 Kalischuk Kalischuk NNP cord-276616-odmnvv7m 426 3 - - HYPH cord-276616-odmnvv7m 426 4 Timensen Timensen NNP cord-276616-odmnvv7m 426 5 helped help VBD cord-276616-odmnvv7m 426 6 collect collect VB cord-276616-odmnvv7m 426 7 references reference NNS cord-276616-odmnvv7m 426 8 by by IN cord-276616-odmnvv7m 426 9 computer computer NN cord-276616-odmnvv7m 426 10 searches search NNS cord-276616-odmnvv7m 426 11 . . . cord-276616-odmnvv7m 427 1 This this DT cord-276616-odmnvv7m 427 2 essay essay NN cord-276616-odmnvv7m 427 3 is be VBZ cord-276616-odmnvv7m 427 4 dedicated dedicate VBN cord-276616-odmnvv7m 427 5 to to IN cord-276616-odmnvv7m 427 6 the the DT cord-276616-odmnvv7m 427 7 memory memory NN cord-276616-odmnvv7m 427 8 of of IN cord-276616-odmnvv7m 427 9 my -PRON- PRP$ cord-276616-odmnvv7m 427 10 friend friend NN cord-276616-odmnvv7m 427 11 Robert Robert NNP cord-276616-odmnvv7m 427 12 Kasting Kasting NNP cord-276616-odmnvv7m 427 13 , , , cord-276616-odmnvv7m 427 14 for for IN cord-276616-odmnvv7m 427 15 his -PRON- PRP$ cord-276616-odmnvv7m 427 16 assistance assistance NN cord-276616-odmnvv7m 427 17 many many JJ cord-276616-odmnvv7m 427 18 years year NNS cord-276616-odmnvv7m 427 19 ago ago RB cord-276616-odmnvv7m 427 20 . . . cord-276616-odmnvv7m 428 1 NOTES note NNS cord-276616-odmnvv7m 428 2 1 1 CD cord-276616-odmnvv7m 428 3 . . . cord-276616-odmnvv7m 429 1 Louping Louping NNP cord-276616-odmnvv7m 429 2 - - HYPH cord-276616-odmnvv7m 429 3 ill ill NNP cord-276616-odmnvv7m 429 4 is be VBZ cord-276616-odmnvv7m 429 5 a a DT cord-276616-odmnvv7m 429 6 tick tick VB cord-276616-odmnvv7m 429 7 - - HYPH cord-276616-odmnvv7m 429 8 borne bear VBN cord-276616-odmnvv7m 429 9 virus virus NN cord-276616-odmnvv7m 429 10 - - HYPH cord-276616-odmnvv7m 429 11 caused cause VBN cord-276616-odmnvv7m 429 12 disease disease NN cord-276616-odmnvv7m 429 13 of of IN cord-276616-odmnvv7m 429 14 lambs lamb NNS cord-276616-odmnvv7m 429 15 , , , cord-276616-odmnvv7m 429 16 characterized characterize VBN cord-276616-odmnvv7m 429 17 by by IN cord-276616-odmnvv7m 429 18 incoordination incoordination NN cord-276616-odmnvv7m 429 19 of of IN cord-276616-odmnvv7m 429 20 the the DT cord-276616-odmnvv7m 429 21 hind hind NN cord-276616-odmnvv7m 429 22 limbs limb NNS cord-276616-odmnvv7m 429 23 and and CC cord-276616-odmnvv7m 429 24 by by IN cord-276616-odmnvv7m 429 25 hypersensitivity hypersensitivity NN cord-276616-odmnvv7m 429 26 to to IN cord-276616-odmnvv7m 429 27 noise noise NN cord-276616-odmnvv7m 429 28 and and CC cord-276616-odmnvv7m 429 29 touch touch VB cord-276616-odmnvv7m 429 30 ( ( -LRB- cord-276616-odmnvv7m 429 31 Blood blood NN cord-276616-odmnvv7m 429 32 et et NNP cord-276616-odmnvv7m 429 33 al al NNP cord-276616-odmnvv7m 429 34 . . NNP cord-276616-odmnvv7m 429 35 , , , cord-276616-odmnvv7m 429 36 1983 1983 CD cord-276616-odmnvv7m 429 37 ) ) -RRB- cord-276616-odmnvv7m 429 38 , , , cord-276616-odmnvv7m 429 39 seen see VBN cord-276616-odmnvv7m 429 40 principally principally RB cord-276616-odmnvv7m 429 41 in in IN cord-276616-odmnvv7m 429 42 Great Great NNP cord-276616-odmnvv7m 429 43 Britain Britain NNP cord-276616-odmnvv7m 429 44 and and CC cord-276616-odmnvv7m 429 45 Russia Russia NNP cord-276616-odmnvv7m 429 46 . . .