id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-321657-2s1npse5	Du, Sean Quan	Mathematical modeling of interaction between innate and adaptive immune responses in COVID‐19 and implications for viral pathogenesis	2020-05-13		.txt	text/plain	6461	294	59	4 In this paper, we used mathematical modeling to investigate the dynamics of the viral infection/replication inside a human host, in particular, the influenza and the SARS-CoV-2 virus, as well as the interactions of target cells with the innate and AIRs. Our model suggests that most of the differences between the two types of infections can potentially be attributed to the timing mismatch between the two immune responses. More specifically, influenza is a very acute infection; all vulnerable cells are completely depleted and viruses are more or less cleared by the innate immune response, before the adaptive immune response (AIR), which has a transient nature, reaches a significant level. We proposed an immune-suppressing treatment based on the leanings of our modeling study, which is to apply immunosuppressive drugs during the early phase of infection to reduce the AIRs to a level low enough not to interfere with the innate immune response.	./cache/cord-321657-2s1npse5.txt	./txt/cord-321657-2s1npse5.txt