id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-317472-6ese0c0e	Zisman, Lawrence S.	ACE and ACE2: a tale of two enzymes	2005-02-01		.txt	text/plain	1505	102	53	In response to RAAS activation there is an increase, at the level of both gene and protein expression, of components which decrease the local concentration of Ang II and which generate bioactive compounds that counteract Ang II-mediated effects. 5 ACE2 may be important as a counter-regulatory enzyme not only because it decreases local cardiac Ang II concentrations, but also because its product Ang-(1-7) mediates specific effects through its recently identified receptor, the mas oncogene product (MAS). The authors found a marked increase in ACE2 gene expression in the border/infarct zone as well as in viable myocardium in the post-myocardial infarction rat heart. 9 Furthermore, it has been shown that ACE2 gene expression and activity are markedly increased in failing human heart. ACE2 gene expression is up-regulated in the human failing heart Increased angiotensin-(1-7) forming activity in failing human heart ventricles: evidence for upregulation of the angiotensinconverting enzyme homologue	./cache/cord-317472-6ese0c0e.txt	./txt/cord-317472-6ese0c0e.txt