id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-333580-tw9cehxv	Ferrario, Carlos M.	Commentary on “angiotensin-converting enzyme inhibitors and angiotensin receptor blockers may be harmful in patients with diabetes during COVID-19 pandemic”	2020-07-24		.txt	text/plain	578	49	53	title: Commentary on "angiotensin-converting enzyme inhibitors and angiotensin receptor blockers may be harmful in patients with diabetes during COVID-19 pandemic" In their interesting article which outlines concerns regarding the potential adverse evolution of SARS-CoV-2 infection in diabetic patients medicated with blockers of the renin angiotensin system (RAS), it is incorrectly stated that angiotensin converting enzyme 2 (ACE2; EC 3.4.17.23) hydrolyzes angiotensin-(1-9) [Ang-(1-9)] into angiotensin-(1-7) [Ang-(1-7)]. The second point that needs correction is the suggestion that angiotensin receptor blockers (ARBs) cause a reduction in Ang II levels (plasma, tissue?) in part by upregulation of Ace2 gene transcription and increased enzymatic activity [3] . Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers may be harmful in patients with diabetes during COVID-19 pandemic Increased expression of angiotensin converting enzyme 2 in conjunction with reduction of neointima by angiotensin II type 1 receptor blockade	./cache/cord-333580-tw9cehxv.txt	./txt/cord-333580-tw9cehxv.txt