id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-342271-m9tn3qu0	Lambert, Daniel W.	Angiotensin-converting enzyme 2 and new insights into the renin–angiotensin system	2008-02-15		.txt	text/plain	4294	193	44	ACE2 displays homology to two quite distinct proteins; its amino-terminal domain shares approximately 40% sequence identity with ACE, whereas its cytoplasmic and transmembrane domains display 48% homology to collectrin, a non-catalytic protein recently shown to have a critical role in amino acid absorption in the kidney [3, 4] , pancreatic beta cell proliferation [5] and insulin exocytosis [6] . The high level of expression of ACE2 in the heart together with its ability to hydrolyse angiotensin peptides have suggested a role for ACE2 in maintaining cardiovascular physiology from the outset, a hypothesis subsequently supported by experimental data. A role for the RAS in the development of lung disease has been suggested by studies in rodents showing AT1 receptor antagonists protect against experimentally induced pulmonary fibrosis [33] , and an increased mortality rate in acute respiratory distress syndrome (ARDS) patients carrying the ACE DD polymorphism [34] .	./cache/cord-342271-m9tn3qu0.txt	./txt/cord-342271-m9tn3qu0.txt