id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-343225-8nxsrod5	Marquez, Alonso	An update on ACE2 amplification and its therapeutic potential	2020-05-29		.txt	text/plain	6092	382	46	RAS blockade based on inhibiting the formation of Ang II with ACE inhibitors or blocking the activation of the Ang II type 1 (AT1) receptor is a widely used therapy for kidney and cardiovascular disease. has deleterious effects to increase blood pressure and exacerbate cardiac fibrosis in subtotal nephrectomy rats kidney disease model in association with increased cardiac ACE activity 51,52 In one study human recombinant ACE2 was shown to improve diabetic kidney disease in Akita mice 104 . Podocyte-specific overexpression of human angiotensin-converting enzyme 2 attenuates diabetic nephropathy in mice Angiotensin-converting enzyme (ACE) 2 overexpression ameliorates glomerular injury in a rat model of diabetic nephropathy: a comparison with ACE inhibition Angiotensin-converting enzyme 2 amplification limited to the circulation does not protect mice from development of diabetic nephropathy A potential therapeutic role for angiotensin-converting enzyme 2 in human pulmonary arterial hypertension. A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury	./cache/cord-343225-8nxsrod5.txt	./txt/cord-343225-8nxsrod5.txt