id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-337028-8fh4pe3i	Reyes, Leticia	Different inflammatory responses are associated with Ureaplasma parvum-induced UTI and urolith formation	2009-01-26		.txt	text/plain	5823	298	46	Animals were inoculated with sterile broth, 10(1), 10(3), 10(5), 10(7), or 10(9 )log CFU of a rat-adapted strain of Ureaplasma parvum. UTI complicated with struvite formation was characterized by an exaggerated immune response that was mostly neutrophilic (P ≤ 0.0001), with lesions that showed extensive uroepithelial hyperplasia (P ≤ 0.0001), and a predominance of IL-1α, IL-1β, and GRO/KC in the urine (P ≤ 0.02). Interestingly, the other 40% of F344 rats developed uncomplicated UTI that was characterized by low concentrations of pro-inflammatory cytokines in urine as well as mild to moderate lesions in the lower urinary tract. In order to identify distinctive chemokine/cytokine patterns between clinical profiles associated with active infection, samples from animals within the Negative group were excluded from this analysis. As previously reported [13] , animals with asymptomatic UTI had significantly less pro-inflammatory urine cytokines and tissue damage when compared to rats with struvites. parvum in culture negative F344 rats Figure 7 Profiling the inflammatory response to different doses of U.	./cache/cord-337028-8fh4pe3i.txt	./txt/cord-337028-8fh4pe3i.txt