id sid tid token lemma pos cord-015021-pol2qm74 1 1 key key JJ cord-015021-pol2qm74 1 2 : : : cord-015021-pol2qm74 1 3 cord-015021-pol2qm74 cord-015021-pol2qm74 NN cord-015021-pol2qm74 1 4 authors author NNS cord-015021-pol2qm74 1 5 : : : cord-015021-pol2qm74 2 1 nan nan NNP cord-015021-pol2qm74 2 2 title title NN cord-015021-pol2qm74 2 3 : : : cord-015021-pol2qm74 3 1 Third Third NNP cord-015021-pol2qm74 3 2 International International NNP cord-015021-pol2qm74 3 3 Congress Congress NNP cord-015021-pol2qm74 3 4 on on IN cord-015021-pol2qm74 3 5 the the DT cord-015021-pol2qm74 3 6 Immune Immune NNP cord-015021-pol2qm74 3 7 Consequences consequence NNS cord-015021-pol2qm74 3 8 of of IN cord-015021-pol2qm74 3 9 Trauma trauma NN cord-015021-pol2qm74 3 10 , , , cord-015021-pol2qm74 3 11 Shock Shock NNP cord-015021-pol2qm74 3 12 and and CC cord-015021-pol2qm74 3 13 Sepsis sepsis NN cord-015021-pol2qm74 3 14 — — : cord-015021-pol2qm74 3 15 Mechanisms mechanism NNS cord-015021-pol2qm74 3 16 and and CC cord-015021-pol2qm74 3 17 Therapeutic therapeutic JJ cord-015021-pol2qm74 3 18 Approaches Approaches NNP cord-015021-pol2qm74 3 19 date date NN cord-015021-pol2qm74 3 20 : : : cord-015021-pol2qm74 3 21 1994 1994 CD cord-015021-pol2qm74 3 22 journal journal NN cord-015021-pol2qm74 3 23 : : : cord-015021-pol2qm74 3 24 Intensive Intensive NNP cord-015021-pol2qm74 3 25 Care care NN cord-015021-pol2qm74 3 26 Med Med NNP cord-015021-pol2qm74 3 27 DOI doi NN cord-015021-pol2qm74 3 28 : : : cord-015021-pol2qm74 4 1 10.1007 10.1007 CD cord-015021-pol2qm74 4 2 / / SYM cord-015021-pol2qm74 4 3 bf02258437 bf02258437 NNP cord-015021-pol2qm74 4 4 sha sha NNP cord-015021-pol2qm74 4 5 : : : cord-015021-pol2qm74 5 1 a8f598af282543b2862ab62a4c671754a94c8a5e a8f598af282543b2862ab62a4c671754a94c8a5e NNP cord-015021-pol2qm74 5 2 doc_id doc_id CD cord-015021-pol2qm74 5 3 : : : cord-015021-pol2qm74 5 4 15021 15021 CD cord-015021-pol2qm74 5 5 cord_uid cord_uid FW cord-015021-pol2qm74 5 6 : : : cord-015021-pol2qm74 6 1 pol2qm74 pol2qm74 NNP cord-015021-pol2qm74 7 1 nan nan NNP cord-015021-pol2qm74 8 1 This this DT cord-015021-pol2qm74 8 2 issue issue NN cord-015021-pol2qm74 8 3 of of IN cord-015021-pol2qm74 8 4 the the DT cord-015021-pol2qm74 8 5 journal journal NN cord-015021-pol2qm74 8 6 contains contain VBZ cord-015021-pol2qm74 8 7 the the DT cord-015021-pol2qm74 8 8 abstracts abstract NNS cord-015021-pol2qm74 8 9 for for IN cord-015021-pol2qm74 8 10 the the DT cord-015021-pol2qm74 8 11 Third Third NNP cord-015021-pol2qm74 8 12 International International NNP cord-015021-pol2qm74 8 13 Congress Congress NNP cord-015021-pol2qm74 8 14 on on IN cord-015021-pol2qm74 8 15 the the DT cord-015021-pol2qm74 8 16 Immune Immune NNP cord-015021-pol2qm74 8 17 Consequences consequence NNS cord-015021-pol2qm74 8 18 of of IN cord-015021-pol2qm74 8 19 Trauma trauma NN cord-015021-pol2qm74 8 20 , , , cord-015021-pol2qm74 8 21 Shock Shock NNP cord-015021-pol2qm74 8 22 and and CC cord-015021-pol2qm74 8 23 Sepsis Sepsis NNP cord-015021-pol2qm74 8 24 -Mechanisms -mechanism NNS cord-015021-pol2qm74 8 25 and and CC cord-015021-pol2qm74 8 26 Therapeutic therapeutic JJ cord-015021-pol2qm74 8 27 Approaches approach NNS cord-015021-pol2qm74 8 28 . . . cord-015021-pol2qm74 9 1 We -PRON- PRP cord-015021-pol2qm74 9 2 hope hope VBP cord-015021-pol2qm74 9 3 that that IN cord-015021-pol2qm74 9 4 the the DT cord-015021-pol2qm74 9 5 information information NN cord-015021-pol2qm74 9 6 contained contain VBN cord-015021-pol2qm74 9 7 in in IN cord-015021-pol2qm74 9 8 this this DT cord-015021-pol2qm74 9 9 special special JJ cord-015021-pol2qm74 9 10 issue issue NN cord-015021-pol2qm74 9 11 will will MD cord-015021-pol2qm74 9 12 stimulate stimulate VB cord-015021-pol2qm74 9 13 you -PRON- PRP cord-015021-pol2qm74 9 14 to to TO cord-015021-pol2qm74 9 15 participate participate VB cord-015021-pol2qm74 9 16 in in IN cord-015021-pol2qm74 9 17 the the DT cord-015021-pol2qm74 9 18 congress congress NNP cord-015021-pol2qm74 9 19 , , , cord-015021-pol2qm74 9 20 to to TO cord-015021-pol2qm74 9 21 contribute contribute VB cord-015021-pol2qm74 9 22 to to IN cord-015021-pol2qm74 9 23 the the DT cord-015021-pol2qm74 9 24 knowledge knowledge NN cord-015021-pol2qm74 9 25 being be VBG cord-015021-pol2qm74 9 26 developed develop VBN cord-015021-pol2qm74 9 27 in in IN cord-015021-pol2qm74 9 28 this this DT cord-015021-pol2qm74 9 29 field field NN cord-015021-pol2qm74 9 30 and and CC cord-015021-pol2qm74 9 31 to to TO cord-015021-pol2qm74 9 32 use use VB cord-015021-pol2qm74 9 33 this this DT cord-015021-pol2qm74 9 34 information information NN cord-015021-pol2qm74 9 35 to to TO cord-015021-pol2qm74 9 36 help help VB cord-015021-pol2qm74 9 37 you -PRON- PRP cord-015021-pol2qm74 9 38 in in IN cord-015021-pol2qm74 9 39 providing provide VBG cord-015021-pol2qm74 9 40 better well JJR cord-015021-pol2qm74 9 41 care care NN cord-015021-pol2qm74 9 42 for for IN cord-015021-pol2qm74 9 43 your -PRON- PRP$ cord-015021-pol2qm74 9 44 patients patient NNS cord-015021-pol2qm74 9 45 . . . cord-015021-pol2qm74 10 1 We -PRON- PRP cord-015021-pol2qm74 10 2 thank thank VBP cord-015021-pol2qm74 10 3 the the DT cord-015021-pol2qm74 10 4 editors editor NNS cord-015021-pol2qm74 10 5 and and CC cord-015021-pol2qm74 10 6 the the DT cord-015021-pol2qm74 10 7 editorial editorial JJ cord-015021-pol2qm74 10 8 board board NN cord-015021-pol2qm74 10 9 and and CC cord-015021-pol2qm74 10 10 publishers publisher NNS cord-015021-pol2qm74 10 11 of of IN cord-015021-pol2qm74 10 12 the the DT cord-015021-pol2qm74 10 13 journal journal NN cord-015021-pol2qm74 10 14 for for IN cord-015021-pol2qm74 10 15 their -PRON- PRP$ cord-015021-pol2qm74 10 16 interest interest NN cord-015021-pol2qm74 10 17 and and CC cord-015021-pol2qm74 10 18 support support NN cord-015021-pol2qm74 10 19 in in IN cord-015021-pol2qm74 10 20 preparation preparation NN cord-015021-pol2qm74 10 21 of of IN cord-015021-pol2qm74 10 22 this this DT cord-015021-pol2qm74 10 23 special special JJ cord-015021-pol2qm74 10 24 issue issue NN cord-015021-pol2qm74 10 25 . . . cord-015021-pol2qm74 11 1 We -PRON- PRP cord-015021-pol2qm74 11 2 also also RB cord-015021-pol2qm74 11 3 , , , cord-015021-pol2qm74 11 4 on on IN cord-015021-pol2qm74 11 5 behalf behalf NN cord-015021-pol2qm74 11 6 of of IN cord-015021-pol2qm74 11 7 the the DT cord-015021-pol2qm74 11 8 scientific scientific JJ cord-015021-pol2qm74 11 9 committee committee NN cord-015021-pol2qm74 11 10 , , , cord-015021-pol2qm74 11 11 welcome welcome VBP cord-015021-pol2qm74 11 12 you -PRON- PRP cord-015021-pol2qm74 11 13 to to IN cord-015021-pol2qm74 11 14 the the DT cord-015021-pol2qm74 11 15 Third Third NNP cord-015021-pol2qm74 11 16 International International NNP cord-015021-pol2qm74 11 17 Congress Congress NNP cord-015021-pol2qm74 11 18 in in IN cord-015021-pol2qm74 11 19 Munich Munich NNP cord-015021-pol2qm74 11 20 on on IN cord-015021-pol2qm74 11 21 2 2 CD cord-015021-pol2qm74 11 22 - - SYM cord-015021-pol2qm74 11 23 5 5 CD cord-015021-pol2qm74 11 24 March March NNP cord-015021-pol2qm74 11 25 1994 1994 CD cord-015021-pol2qm74 11 26 . . . cord-015021-pol2qm74 12 1 When when WRB cord-015021-pol2qm74 12 2 , , , cord-015021-pol2qm74 12 3 in in IN cord-015021-pol2qm74 12 4 the the DT cord-015021-pol2qm74 12 5 mid-1980s mid-1980 NNS cord-015021-pol2qm74 12 6 , , , cord-015021-pol2qm74 12 7 we -PRON- PRP cord-015021-pol2qm74 12 8 thought think VBD cord-015021-pol2qm74 12 9 of of IN cord-015021-pol2qm74 12 10 having have VBG cord-015021-pol2qm74 12 11 a a DT cord-015021-pol2qm74 12 12 worldwide worldwide JJ cord-015021-pol2qm74 12 13 congress congress NNP cord-015021-pol2qm74 12 14 , , , cord-015021-pol2qm74 12 15 we -PRON- PRP cord-015021-pol2qm74 12 16 hoped hope VBD cord-015021-pol2qm74 12 17 to to TO cord-015021-pol2qm74 12 18 bring bring VB cord-015021-pol2qm74 12 19 together together RB cord-015021-pol2qm74 12 20 investigators investigator NNS cord-015021-pol2qm74 12 21 to to TO cord-015021-pol2qm74 12 22 discuss discuss VB cord-015021-pol2qm74 12 23 this this DT cord-015021-pol2qm74 12 24 theme theme NN cord-015021-pol2qm74 12 25 . . . cord-015021-pol2qm74 13 1 The the DT cord-015021-pol2qm74 13 2 explosion explosion NN cord-015021-pol2qm74 13 3 of of IN cord-015021-pol2qm74 13 4 knowledge knowledge NN cord-015021-pol2qm74 13 5 occurring occur VBG cord-015021-pol2qm74 13 6 around around IN cord-015021-pol2qm74 13 7 that that DT cord-015021-pol2qm74 13 8 time time NN cord-015021-pol2qm74 13 9 provided provide VBD cord-015021-pol2qm74 13 10 an an DT cord-015021-pol2qm74 13 11 excellent excellent JJ cord-015021-pol2qm74 13 12 background background NN cord-015021-pol2qm74 13 13 against against IN cord-015021-pol2qm74 13 14 which which WDT cord-015021-pol2qm74 13 15 the the DT cord-015021-pol2qm74 13 16 first first JJ cord-015021-pol2qm74 13 17 conference conference NN cord-015021-pol2qm74 13 18 in in IN cord-015021-pol2qm74 13 19 1988 1988 CD cord-015021-pol2qm74 13 20 provided provide VBN cord-015021-pol2qm74 13 21 stateof stateof NN cord-015021-pol2qm74 13 22 - - HYPH cord-015021-pol2qm74 13 23 the the DT cord-015021-pol2qm74 13 24 - - HYPH cord-015021-pol2qm74 13 25 art art NN cord-015021-pol2qm74 13 26 information information NN cord-015021-pol2qm74 13 27 and and CC cord-015021-pol2qm74 13 28 consensus consensus NN cord-015021-pol2qm74 13 29 on on IN cord-015021-pol2qm74 13 30 factors factor NNS cord-015021-pol2qm74 13 31 involved involve VBN cord-015021-pol2qm74 13 32 in in IN cord-015021-pol2qm74 13 33 injury injury NN cord-015021-pol2qm74 13 34 and and CC cord-015021-pol2qm74 13 35 sepsis sepsis NN cord-015021-pol2qm74 13 36 . . . cord-015021-pol2qm74 14 1 In in IN cord-015021-pol2qm74 14 2 1991 1991 CD cord-015021-pol2qm74 14 3 , , , cord-015021-pol2qm74 14 4 the the DT cord-015021-pol2qm74 14 5 Second Second NNP cord-015021-pol2qm74 14 6 Congress Congress NNP cord-015021-pol2qm74 14 7 was be VBD cord-015021-pol2qm74 14 8 held hold VBN cord-015021-pol2qm74 14 9 at at IN cord-015021-pol2qm74 14 10 the the DT cord-015021-pol2qm74 14 11 time time NN cord-015021-pol2qm74 14 12 of of IN cord-015021-pol2qm74 14 13 another another DT cord-015021-pol2qm74 14 14 resurgence resurgence NN cord-015021-pol2qm74 14 15 of of IN cord-015021-pol2qm74 14 16 research research NN cord-015021-pol2qm74 14 17 , , , cord-015021-pol2qm74 14 18 study study NN cord-015021-pol2qm74 14 19 and and CC cord-015021-pol2qm74 14 20 information information NN cord-015021-pol2qm74 14 21 on on IN cord-015021-pol2qm74 14 22 injured injure VBN cord-015021-pol2qm74 14 23 and and CC cord-015021-pol2qm74 14 24 operated operate VBN cord-015021-pol2qm74 14 25 patients patient NNS cord-015021-pol2qm74 14 26 . . . cord-015021-pol2qm74 15 1 It -PRON- PRP cord-015021-pol2qm74 15 2 seemed seem VBD cord-015021-pol2qm74 15 3 then then RB cord-015021-pol2qm74 15 4 that that IN cord-015021-pol2qm74 15 5 there there EX cord-015021-pol2qm74 15 6 would would MD cord-015021-pol2qm74 15 7 be be VB cord-015021-pol2qm74 15 8 a a DT cord-015021-pol2qm74 15 9 lull lull NN cord-015021-pol2qm74 15 10 in in IN cord-015021-pol2qm74 15 11 the the DT cord-015021-pol2qm74 15 12 development development NN cord-015021-pol2qm74 15 13 of of IN cord-015021-pol2qm74 15 14 new new JJ cord-015021-pol2qm74 15 15 information information NN cord-015021-pol2qm74 15 16 and and CC cord-015021-pol2qm74 15 17 therapy therapy NN cord-015021-pol2qm74 15 18 , , , cord-015021-pol2qm74 15 19 and and CC cord-015021-pol2qm74 15 20 that that IN cord-015021-pol2qm74 15 21 another another DT cord-015021-pol2qm74 15 22 state state NN cord-015021-pol2qm74 15 23 - - HYPH cord-015021-pol2qm74 15 24 of of IN cord-015021-pol2qm74 15 25 - - HYPH cord-015021-pol2qm74 15 26 the the DT cord-015021-pol2qm74 15 27 art art NN cord-015021-pol2qm74 15 28 conference conference NN cord-015021-pol2qm74 15 29 might may MD cord-015021-pol2qm74 15 30 not not RB cord-015021-pol2qm74 15 31 be be VB cord-015021-pol2qm74 15 32 necessary necessary JJ cord-015021-pol2qm74 15 33 until until IN cord-015021-pol2qm74 15 34 1995 1995 CD cord-015021-pol2qm74 15 35 or or CC cord-015021-pol2qm74 15 36 1996 1996 CD cord-015021-pol2qm74 15 37 . . . cord-015021-pol2qm74 16 1 However however RB cord-015021-pol2qm74 16 2 , , , cord-015021-pol2qm74 16 3 the the DT cord-015021-pol2qm74 16 4 explosion explosion NN cord-015021-pol2qm74 16 5 in in IN cord-015021-pol2qm74 16 6 molecular molecular JJ cord-015021-pol2qm74 16 7 biology biology NN cord-015021-pol2qm74 16 8 has have VBZ cord-015021-pol2qm74 16 9 continued continue VBN cord-015021-pol2qm74 16 10 . . . cord-015021-pol2qm74 17 1 The the DT cord-015021-pol2qm74 17 2 wonderful wonderful JJ cord-015021-pol2qm74 17 3 world world NN cord-015021-pol2qm74 17 4 of of IN cord-015021-pol2qm74 17 5 cytokines cytokine NNS cord-015021-pol2qm74 17 6 has have VBZ cord-015021-pol2qm74 17 7 gone go VBN cord-015021-pol2qm74 17 8 from from IN cord-015021-pol2qm74 17 9 ILl ILl NNP cord-015021-pol2qm74 17 10 to to IN cord-015021-pol2qm74 17 11 IL-6 IL-6 NNP cord-015021-pol2qm74 17 12 to to IN cord-015021-pol2qm74 17 13 IL-11 IL-11 NNP cord-015021-pol2qm74 17 14 , , , cord-015021-pol2qm74 17 15 IL-12 IL-12 NNP cord-015021-pol2qm74 17 16 and and CC cord-015021-pol2qm74 17 17 IL-13 IL-13 NNP cord-015021-pol2qm74 17 18 and and CC cord-015021-pol2qm74 17 19 beyond beyond IN cord-015021-pol2qm74 17 20 . . . cord-015021-pol2qm74 18 1 The the DT cord-015021-pol2qm74 18 2 vast vast JJ cord-015021-pol2qm74 18 3 amount amount NN cord-015021-pol2qm74 18 4 of of IN cord-015021-pol2qm74 18 5 information information NN cord-015021-pol2qm74 18 6 about about IN cord-015021-pol2qm74 18 7 mediators mediator NNS cord-015021-pol2qm74 18 8 and and CC cord-015021-pol2qm74 18 9 their -PRON- PRP$ cord-015021-pol2qm74 18 10 importance importance NN cord-015021-pol2qm74 18 11 in in IN cord-015021-pol2qm74 18 12 disease disease NN cord-015021-pol2qm74 18 13 is be VBZ cord-015021-pol2qm74 18 14 impressive impressive JJ cord-015021-pol2qm74 18 15 . . . cord-015021-pol2qm74 19 1 This this DT cord-015021-pol2qm74 19 2 has have VBZ cord-015021-pol2qm74 19 3 all all RB cord-015021-pol2qm74 19 4 suggested suggest VBN cord-015021-pol2qm74 19 5 a a DT cord-015021-pol2qm74 19 6 magic magic JJ cord-015021-pol2qm74 19 7 bullet bullet NN cord-015021-pol2qm74 19 8 that that WDT cord-015021-pol2qm74 19 9 might may MD cord-015021-pol2qm74 19 10 be be VB cord-015021-pol2qm74 19 11 used use VBN cord-015021-pol2qm74 19 12 to to TO cord-015021-pol2qm74 19 13 alter alter VB cord-015021-pol2qm74 19 14 or or CC cord-015021-pol2qm74 19 15 block block VB cord-015021-pol2qm74 19 16 inflammatory inflammatory JJ cord-015021-pol2qm74 19 17 responses response NNS cord-015021-pol2qm74 19 18 . . . cord-015021-pol2qm74 20 1 This this DT cord-015021-pol2qm74 20 2 has have VBZ cord-015021-pol2qm74 20 3 not not RB cord-015021-pol2qm74 20 4 happened happen VBN cord-015021-pol2qm74 20 5 , , , cord-015021-pol2qm74 20 6 however however RB cord-015021-pol2qm74 20 7 , , , cord-015021-pol2qm74 20 8 and and CC cord-015021-pol2qm74 20 9 the the DT cord-015021-pol2qm74 20 10 question question NN cord-015021-pol2qm74 20 11 is be VBZ cord-015021-pol2qm74 20 12 " " `` cord-015021-pol2qm74 20 13 Why why WRB cord-015021-pol2qm74 20 14 not not RB cord-015021-pol2qm74 20 15 " " '' cord-015021-pol2qm74 20 16 ? ? . cord-015021-pol2qm74 21 1 Our -PRON- PRP$ cord-015021-pol2qm74 21 2 science science NN cord-015021-pol2qm74 21 3 is be VBZ cord-015021-pol2qm74 21 4 powerful powerful JJ cord-015021-pol2qm74 21 5 , , , cord-015021-pol2qm74 21 6 but but CC cord-015021-pol2qm74 21 7 our -PRON- PRP$ cord-015021-pol2qm74 21 8 therapy therapy NN cord-015021-pol2qm74 21 9 is be VBZ cord-015021-pol2qm74 21 10 still still RB cord-015021-pol2qm74 21 11 weak weak JJ cord-015021-pol2qm74 21 12 . . . cord-015021-pol2qm74 22 1 What what WP cord-015021-pol2qm74 22 2 are be VBP cord-015021-pol2qm74 22 3 the the DT cord-015021-pol2qm74 22 4 issues issue NNS cord-015021-pol2qm74 22 5 , , , cord-015021-pol2qm74 22 6 then then RB cord-015021-pol2qm74 22 7 , , , cord-015021-pol2qm74 22 8 in in IN cord-015021-pol2qm74 22 9 1994 1994 CD cord-015021-pol2qm74 22 10 , , , cord-015021-pol2qm74 22 11 to to TO cord-015021-pol2qm74 22 12 be be VB cord-015021-pol2qm74 22 13 dealt deal VBN cord-015021-pol2qm74 22 14 with with IN cord-015021-pol2qm74 22 15 at at IN cord-015021-pol2qm74 22 16 this this DT cord-015021-pol2qm74 22 17 symposium symposium NN cord-015021-pol2qm74 22 18 and and CC cord-015021-pol2qm74 22 19 congress congress NNP cord-015021-pol2qm74 22 20 ? ? . cord-015021-pol2qm74 23 1 ( ( -LRB- cord-015021-pol2qm74 23 2 1 1 LS cord-015021-pol2qm74 23 3 ) ) -RRB- cord-015021-pol2qm74 23 4 Proposals proposal NNS cord-015021-pol2qm74 23 5 for for IN cord-015021-pol2qm74 23 6 new new JJ cord-015021-pol2qm74 23 7 terminology terminology NN cord-015021-pol2qm74 23 8 . . . cord-015021-pol2qm74 24 1 There there EX cord-015021-pol2qm74 24 2 have have VBP cord-015021-pol2qm74 24 3 been be VBN cord-015021-pol2qm74 24 4 a a DT cord-015021-pol2qm74 24 5 number number NN cord-015021-pol2qm74 24 6 of of IN cord-015021-pol2qm74 24 7 proposals proposal NNS cord-015021-pol2qm74 24 8 for for IN cord-015021-pol2qm74 24 9 new new JJ cord-015021-pol2qm74 24 10 terminology terminology NN cord-015021-pol2qm74 24 11 and and CC cord-015021-pol2qm74 24 12 new new JJ cord-015021-pol2qm74 24 13 classifications classification NNS cord-015021-pol2qm74 24 14 of of IN cord-015021-pol2qm74 24 15 injury injury NN cord-015021-pol2qm74 24 16 , , , cord-015021-pol2qm74 24 17 sepsis sepsis NN cord-015021-pol2qm74 24 18 , , , cord-015021-pol2qm74 24 19 inflammation inflammation NN cord-015021-pol2qm74 24 20 and and CC cord-015021-pol2qm74 24 21 various various JJ cord-015021-pol2qm74 24 22 other other JJ cord-015021-pol2qm74 24 23 problems problem NNS cord-015021-pol2qm74 24 24 related relate VBN cord-015021-pol2qm74 24 25 to to IN cord-015021-pol2qm74 24 26 human human JJ cord-015021-pol2qm74 24 27 illness illness NN cord-015021-pol2qm74 24 28 . . . cord-015021-pol2qm74 25 1 The the DT cord-015021-pol2qm74 25 2 question question NN cord-015021-pol2qm74 25 3 is be VBZ cord-015021-pol2qm74 25 4 whether whether IN cord-015021-pol2qm74 25 5 this this DT cord-015021-pol2qm74 25 6 is be VBZ cord-015021-pol2qm74 25 7 the the DT cord-015021-pol2qm74 25 8 way way NN cord-015021-pol2qm74 25 9 to to TO cord-015021-pol2qm74 25 10 go go VB cord-015021-pol2qm74 25 11 . . . cord-015021-pol2qm74 26 1 Will Will MD cord-015021-pol2qm74 26 2 this this DT cord-015021-pol2qm74 26 3 contribute contribute VB cord-015021-pol2qm74 26 4 to to IN cord-015021-pol2qm74 26 5 better well JJR cord-015021-pol2qm74 26 6 clinical clinical JJ cord-015021-pol2qm74 26 7 trials trial NNS cord-015021-pol2qm74 26 8 , , , cord-015021-pol2qm74 26 9 information information NN cord-015021-pol2qm74 26 10 basis basis NN cord-015021-pol2qm74 26 11 and and CC cord-015021-pol2qm74 26 12 better well JJR cord-015021-pol2qm74 26 13 research research NN cord-015021-pol2qm74 26 14 ? ? . cord-015021-pol2qm74 27 1 The the DT cord-015021-pol2qm74 27 2 pros pro NNS cord-015021-pol2qm74 27 3 and and CC cord-015021-pol2qm74 27 4 cons con NNS cord-015021-pol2qm74 27 5 of of IN cord-015021-pol2qm74 27 6 this this DT cord-015021-pol2qm74 27 7 development development NN cord-015021-pol2qm74 27 8 will will MD cord-015021-pol2qm74 27 9 be be VB cord-015021-pol2qm74 27 10 reviewed review VBN cord-015021-pol2qm74 27 11 by by IN cord-015021-pol2qm74 27 12 those those DT cord-015021-pol2qm74 27 13 making make VBG cord-015021-pol2qm74 27 14 the the DT cord-015021-pol2qm74 27 15 proposals proposal NNS cord-015021-pol2qm74 27 16 and and CC cord-015021-pol2qm74 27 17 those those DT cord-015021-pol2qm74 27 18 questioning question VBG cord-015021-pol2qm74 27 19 the the DT cord-015021-pol2qm74 27 20 need need NN cord-015021-pol2qm74 27 21 for for IN cord-015021-pol2qm74 27 22 and and CC cord-015021-pol2qm74 27 23 wisdom wisdom NN cord-015021-pol2qm74 27 24 of of IN cord-015021-pol2qm74 27 25 this this DT cord-015021-pol2qm74 27 26 effort effort NN cord-015021-pol2qm74 27 27 . . . cord-015021-pol2qm74 28 1 ( ( -LRB- cord-015021-pol2qm74 28 2 2 2 LS cord-015021-pol2qm74 28 3 ) ) -RRB- cord-015021-pol2qm74 28 4 Magic magic JJ cord-015021-pol2qm74 28 5 bullets bullet NNS cord-015021-pol2qm74 28 6 : : : cord-015021-pol2qm74 28 7 the the DT cord-015021-pol2qm74 28 8 prospect prospect NN cord-015021-pol2qm74 28 9 of of IN cord-015021-pol2qm74 28 10 a a DT cord-015021-pol2qm74 28 11 magic magic JJ cord-015021-pol2qm74 28 12 bullet bullet NN cord-015021-pol2qm74 28 13 to to TO cord-015021-pol2qm74 28 14 deal deal VB cord-015021-pol2qm74 28 15 with with IN cord-015021-pol2qm74 28 16 inflammation inflammation NN cord-015021-pol2qm74 28 17 in in IN cord-015021-pol2qm74 28 18 injury injury NN cord-015021-pol2qm74 28 19 and and CC cord-015021-pol2qm74 28 20 infection infection NN cord-015021-pol2qm74 28 21 seemed seem VBD cord-015021-pol2qm74 28 22 highly highly RB cord-015021-pol2qm74 28 23 promising promising JJ cord-015021-pol2qm74 28 24 earlier early RBR cord-015021-pol2qm74 28 25 . . . cord-015021-pol2qm74 29 1 Many many JJ cord-015021-pol2qm74 29 2 preclinical preclinical JJ cord-015021-pol2qm74 29 3 trials trial NNS cord-015021-pol2qm74 29 4 and and CC cord-015021-pol2qm74 29 5 a a DT cord-015021-pol2qm74 29 6 lot lot NN cord-015021-pol2qm74 29 7 of of IN cord-015021-pol2qm74 29 8 animal animal NN cord-015021-pol2qm74 29 9 research research NN cord-015021-pol2qm74 29 10 suggested suggest VBD cord-015021-pol2qm74 29 11 the the DT cord-015021-pol2qm74 29 12 possibility possibility NN cord-015021-pol2qm74 29 13 of of IN cord-015021-pol2qm74 29 14 a a DT cord-015021-pol2qm74 29 15 great great JJ cord-015021-pol2qm74 29 16 breakthrough breakthrough NN cord-015021-pol2qm74 29 17 in in IN cord-015021-pol2qm74 29 18 clinical clinical JJ cord-015021-pol2qm74 29 19 care care NN cord-015021-pol2qm74 29 20 . . . cord-015021-pol2qm74 30 1 What what WP cord-015021-pol2qm74 30 2 has have VBZ cord-015021-pol2qm74 30 3 become become VBN cord-015021-pol2qm74 30 4 , , , cord-015021-pol2qm74 30 5 then then RB cord-015021-pol2qm74 30 6 , , , cord-015021-pol2qm74 30 7 of of IN cord-015021-pol2qm74 30 8 all all PDT cord-015021-pol2qm74 30 9 the the DT cord-015021-pol2qm74 30 10 expensive expensive JJ cord-015021-pol2qm74 30 11 and and CC cord-015021-pol2qm74 30 12 extensive extensive JJ cord-015021-pol2qm74 30 13 multi multi JJ cord-015021-pol2qm74 30 14 - - NN cord-015021-pol2qm74 30 15 institution institution NN cord-015021-pol2qm74 30 16 randomized randomize VBN cord-015021-pol2qm74 30 17 , , , cord-015021-pol2qm74 30 18 placebo placebo NN cord-015021-pol2qm74 30 19 - - HYPH cord-015021-pol2qm74 30 20 controlled control VBN cord-015021-pol2qm74 30 21 , , , cord-015021-pol2qm74 30 22 double double JJ cord-015021-pol2qm74 30 23 - - HYPH cord-015021-pol2qm74 30 24 blind blind JJ cord-015021-pol2qm74 30 25 clinical clinical JJ cord-015021-pol2qm74 30 26 trials trial NNS cord-015021-pol2qm74 30 27 of of IN cord-015021-pol2qm74 30 28 agents agent NNS cord-015021-pol2qm74 30 29 that that WDT cord-015021-pol2qm74 30 30 block block VBP cord-015021-pol2qm74 30 31 mediators mediator NNS cord-015021-pol2qm74 30 32 and and CC cord-015021-pol2qm74 30 33 endotoxin endotoxin NN cord-015021-pol2qm74 30 34 . . . cord-015021-pol2qm74 31 1 Many many JJ cord-015021-pol2qm74 31 2 such such JJ cord-015021-pol2qm74 31 3 studies study NNS cord-015021-pol2qm74 31 4 have have VBP cord-015021-pol2qm74 31 5 yielded yield VBN cord-015021-pol2qm74 31 6 equivocal equivocal JJ cord-015021-pol2qm74 31 7 , , , cord-015021-pol2qm74 31 8 marginal marginal JJ cord-015021-pol2qm74 31 9 or or CC cord-015021-pol2qm74 31 10 negative negative JJ cord-015021-pol2qm74 31 11 results result NNS cord-015021-pol2qm74 31 12 . . . cord-015021-pol2qm74 32 1 The the DT cord-015021-pol2qm74 32 2 reasons reason NNS cord-015021-pol2qm74 32 3 for for IN cord-015021-pol2qm74 32 4 this this DT cord-015021-pol2qm74 32 5 and and CC cord-015021-pol2qm74 32 6 the the DT cord-015021-pol2qm74 32 7 future future NN cord-015021-pol2qm74 32 8 of of IN cord-015021-pol2qm74 32 9 clinical clinical JJ cord-015021-pol2qm74 32 10 research research NN cord-015021-pol2qm74 32 11 will will MD cord-015021-pol2qm74 32 12 be be VB cord-015021-pol2qm74 32 13 the the DT cord-015021-pol2qm74 32 14 subject subject NN cord-015021-pol2qm74 32 15 of of IN cord-015021-pol2qm74 32 16 presentations presentation NNS cord-015021-pol2qm74 32 17 and and CC cord-015021-pol2qm74 32 18 discussions discussion NNS cord-015021-pol2qm74 32 19 to to TO cord-015021-pol2qm74 32 20 set set VB cord-015021-pol2qm74 32 21 the the DT cord-015021-pol2qm74 32 22 stage stage NN cord-015021-pol2qm74 32 23 for for IN cord-015021-pol2qm74 32 24 further further JJ cord-015021-pol2qm74 32 25 work work NN cord-015021-pol2qm74 32 26 . . . cord-015021-pol2qm74 33 1 ( ( -LRB- cord-015021-pol2qm74 33 2 3 3 LS cord-015021-pol2qm74 33 3 ) ) -RRB- cord-015021-pol2qm74 33 4 Should Should MD cord-015021-pol2qm74 33 5 future future VB cord-015021-pol2qm74 33 6 clinical clinical JJ cord-015021-pol2qm74 33 7 trials trial NNS cord-015021-pol2qm74 33 8 be be VB cord-015021-pol2qm74 33 9 based base VBN cord-015021-pol2qm74 33 10 on on IN cord-015021-pol2qm74 33 11 new new JJ cord-015021-pol2qm74 33 12 classifications classification NNS cord-015021-pol2qm74 33 13 of of IN cord-015021-pol2qm74 33 14 illness illness NN cord-015021-pol2qm74 33 15 such such JJ cord-015021-pol2qm74 33 16 as as IN cord-015021-pol2qm74 33 17 MODS MODS NNP cord-015021-pol2qm74 33 18 , , , cord-015021-pol2qm74 33 19 SIRS SIRS NNP cord-015021-pol2qm74 33 20 , , , cord-015021-pol2qm74 33 21 APACHE APACHE NNP cord-015021-pol2qm74 33 22 III III NNP cord-015021-pol2qm74 33 23 , , , cord-015021-pol2qm74 33 24 SAP SAP NNP cord-015021-pol2qm74 33 25 II II NNP cord-015021-pol2qm74 33 26 , , , cord-015021-pol2qm74 33 27 MRM MRM NNP cord-015021-pol2qm74 33 28 , , , cord-015021-pol2qm74 33 29 etc etc FW cord-015021-pol2qm74 33 30 . . FW cord-015021-pol2qm74 33 31 , , , cord-015021-pol2qm74 33 32 or or CC cord-015021-pol2qm74 33 33 should should MD cord-015021-pol2qm74 33 34 trials trial NNS cord-015021-pol2qm74 33 35 be be VB cord-015021-pol2qm74 33 36 dedicated dedicated JJ cord-015021-pol2qm74 33 37 to to IN cord-015021-pol2qm74 33 38 specific specific JJ cord-015021-pol2qm74 33 39 diseases disease NNS cord-015021-pol2qm74 33 40 -urinary -urinary JJ cord-015021-pol2qm74 33 41 tract tract JJ cord-015021-pol2qm74 33 42 infections infection NNS cord-015021-pol2qm74 33 43 , , , cord-015021-pol2qm74 33 44 pneumonia pneumonia NN cord-015021-pol2qm74 33 45 , , , cord-015021-pol2qm74 33 46 trauma trauma NN cord-015021-pol2qm74 33 47 patients patient NNS cord-015021-pol2qm74 33 48 , , , cord-015021-pol2qm74 33 49 cardiac cardiac JJ cord-015021-pol2qm74 33 50 surgery surgery NN cord-015021-pol2qm74 33 51 and and CC cord-015021-pol2qm74 33 52 other other JJ cord-015021-pol2qm74 33 53 specific specific JJ cord-015021-pol2qm74 33 54 problems problem NNS cord-015021-pol2qm74 33 55 , , , cord-015021-pol2qm74 33 56 rather rather RB cord-015021-pol2qm74 33 57 than than IN cord-015021-pol2qm74 33 58 generalized generalized JJ cord-015021-pol2qm74 33 59 problems problem NNS cord-015021-pol2qm74 33 60 of of IN cord-015021-pol2qm74 33 61 sepsis sepsis NN cord-015021-pol2qm74 33 62 , , , cord-015021-pol2qm74 33 63 the the DT cord-015021-pol2qm74 33 64 sepsis sepsis NN cord-015021-pol2qm74 33 65 syndrome syndrome NN cord-015021-pol2qm74 33 66 and and CC cord-015021-pol2qm74 33 67 other other JJ cord-015021-pol2qm74 33 68 classifications classification NNS cord-015021-pol2qm74 33 69 ? ? . cord-015021-pol2qm74 34 1 In in IN cord-015021-pol2qm74 34 2 other other JJ cord-015021-pol2qm74 34 3 words word NNS cord-015021-pol2qm74 34 4 , , , cord-015021-pol2qm74 34 5 should should MD cord-015021-pol2qm74 34 6 we -PRON- PRP cord-015021-pol2qm74 34 7 now now RB cord-015021-pol2qm74 34 8 begin begin VB cord-015021-pol2qm74 34 9 to to TO cord-015021-pol2qm74 34 10 have have VB cord-015021-pol2qm74 34 11 clinical clinical JJ cord-015021-pol2qm74 34 12 trials trial NNS cord-015021-pol2qm74 34 13 on on IN cord-015021-pol2qm74 34 14 specific specific JJ cord-015021-pol2qm74 34 15 diseases disease NNS cord-015021-pol2qm74 34 16 with with IN cord-015021-pol2qm74 34 17 causes cause NNS cord-015021-pol2qm74 34 18 that that WDT cord-015021-pol2qm74 34 19 are be VBP cord-015021-pol2qm74 34 20 known know VBN cord-015021-pol2qm74 34 21 and and CC cord-015021-pol2qm74 34 22 can can MD cord-015021-pol2qm74 34 23 be be VB cord-015021-pol2qm74 34 24 attacked attack VBN cord-015021-pol2qm74 34 25 ? ? . cord-015021-pol2qm74 35 1 The the DT cord-015021-pol2qm74 35 2 causality causality NN cord-015021-pol2qm74 35 3 of of IN cord-015021-pol2qm74 35 4 disease disease NN cord-015021-pol2qm74 35 5 becomes become VBZ cord-015021-pol2qm74 35 6 an an DT cord-015021-pol2qm74 35 7 important important JJ cord-015021-pol2qm74 35 8 consideration consideration NN cord-015021-pol2qm74 35 9 in in IN cord-015021-pol2qm74 35 10 this this DT cord-015021-pol2qm74 35 11 regard regard NN cord-015021-pol2qm74 35 12 . . . cord-015021-pol2qm74 36 1 ( ( -LRB- cord-015021-pol2qm74 36 2 4 4 LS cord-015021-pol2qm74 36 3 ) ) -RRB- cord-015021-pol2qm74 37 1 A a DT cord-015021-pol2qm74 37 2 multitude multitude NN cord-015021-pol2qm74 37 3 of of IN cord-015021-pol2qm74 37 4 potential potential JJ cord-015021-pol2qm74 37 5 therapeutic therapeutic JJ cord-015021-pol2qm74 37 6 agents agent NNS cord-015021-pol2qm74 37 7 has have VBZ cord-015021-pol2qm74 37 8 been be VBN cord-015021-pol2qm74 37 9 proposed propose VBN cord-015021-pol2qm74 37 10 on on IN cord-015021-pol2qm74 37 11 the the DT cord-015021-pol2qm74 37 12 basis basis NN cord-015021-pol2qm74 37 13 of of IN cord-015021-pol2qm74 37 14 animal animal NN cord-015021-pol2qm74 37 15 studies study NNS cord-015021-pol2qm74 37 16 . . . cord-015021-pol2qm74 38 1 How how WRB cord-015021-pol2qm74 38 2 should should MD cord-015021-pol2qm74 38 3 we -PRON- PRP cord-015021-pol2qm74 38 4 decide decide VB cord-015021-pol2qm74 38 5 which which WDT cord-015021-pol2qm74 38 6 of of IN cord-015021-pol2qm74 38 7 them -PRON- PRP cord-015021-pol2qm74 38 8 should should MD cord-015021-pol2qm74 38 9 be be VB cord-015021-pol2qm74 38 10 brought bring VBN cord-015021-pol2qm74 38 11 to to IN cord-015021-pol2qm74 38 12 clinical clinical JJ cord-015021-pol2qm74 38 13 trial trial NN cord-015021-pol2qm74 38 14 ? ? . cord-015021-pol2qm74 39 1 The the DT cord-015021-pol2qm74 39 2 possibilities possibility NNS cord-015021-pol2qm74 39 3 are be VBP cord-015021-pol2qm74 39 4 endless endless JJ cord-015021-pol2qm74 39 5 as as IN cord-015021-pol2qm74 39 6 we -PRON- PRP cord-015021-pol2qm74 39 7 develop develop VBP cord-015021-pol2qm74 39 8 new new JJ cord-015021-pol2qm74 39 9 clinical clinical JJ cord-015021-pol2qm74 39 10 information information NN cord-015021-pol2qm74 39 11 about about IN cord-015021-pol2qm74 39 12 the the DT cord-015021-pol2qm74 39 13 mechanisms mechanism NNS cord-015021-pol2qm74 39 14 and and CC cord-015021-pol2qm74 39 15 pathogenesis pathogenesis NN cord-015021-pol2qm74 39 16 of of IN cord-015021-pol2qm74 39 17 human human JJ cord-015021-pol2qm74 39 18 disease disease NN cord-015021-pol2qm74 39 19 . . . cord-015021-pol2qm74 40 1 ( ( -LRB- cord-015021-pol2qm74 40 2 5 5 LS cord-015021-pol2qm74 40 3 ) ) -RRB- cord-015021-pol2qm74 40 4 Information information NN cord-015021-pol2qm74 40 5 on on IN cord-015021-pol2qm74 40 6 the the DT cord-015021-pol2qm74 40 7 pathogenic pathogenic JJ cord-015021-pol2qm74 40 8 mechanism mechanism NN cord-015021-pol2qm74 40 9 of of IN cord-015021-pol2qm74 40 10 disease disease NN cord-015021-pol2qm74 40 11 states state NNS cord-015021-pol2qm74 40 12 and and CC cord-015021-pol2qm74 40 13 of of IN cord-015021-pol2qm74 40 14 injury injury NN cord-015021-pol2qm74 40 15 continued continue VBD cord-015021-pol2qm74 40 16 to to TO cord-015021-pol2qm74 40 17 emerge emerge VB cord-015021-pol2qm74 40 18 in in IN cord-015021-pol2qm74 40 19 an an DT cord-015021-pol2qm74 40 20 explosive explosive JJ cord-015021-pol2qm74 40 21 fashion fashion NN cord-015021-pol2qm74 40 22 , , , cord-015021-pol2qm74 40 23 and and CC cord-015021-pol2qm74 40 24 in in IN cord-015021-pol2qm74 40 25 light light NN cord-015021-pol2qm74 40 26 of of IN cord-015021-pol2qm74 40 27 our -PRON- PRP$ cord-015021-pol2qm74 40 28 gathering gathering NN cord-015021-pol2qm74 40 29 knowledge knowledge NN cord-015021-pol2qm74 40 30 we -PRON- PRP cord-015021-pol2qm74 40 31 can can MD cord-015021-pol2qm74 40 32 look look VB cord-015021-pol2qm74 40 33 forward forward RB cord-015021-pol2qm74 40 34 to to IN cord-015021-pol2qm74 40 35 working work VBG cord-015021-pol2qm74 40 36 out out RP cord-015021-pol2qm74 40 37 a a DT cord-015021-pol2qm74 40 38 cohesive cohesive JJ cord-015021-pol2qm74 40 39 system system NN cord-015021-pol2qm74 40 40 of of IN cord-015021-pol2qm74 40 41 response response NN cord-015021-pol2qm74 40 42 to to IN cord-015021-pol2qm74 40 43 injury injury NN cord-015021-pol2qm74 40 44 . . . cord-015021-pol2qm74 41 1 ( ( -LRB- cord-015021-pol2qm74 41 2 6 6 CD cord-015021-pol2qm74 41 3 ) ) -RRB- cord-015021-pol2qm74 42 1 Additional additional JJ cord-015021-pol2qm74 42 2 information information NN cord-015021-pol2qm74 42 3 will will MD cord-015021-pol2qm74 42 4 be be VB cord-015021-pol2qm74 42 5 provided provide VBN cord-015021-pol2qm74 42 6 in in IN cord-015021-pol2qm74 42 7 plenary plenary JJ cord-015021-pol2qm74 42 8 sections section NNS cord-015021-pol2qm74 42 9 , , , cord-015021-pol2qm74 42 10 many many JJ cord-015021-pol2qm74 42 11 symposia symposium NNS cord-015021-pol2qm74 42 12 and and CC cord-015021-pol2qm74 42 13 free free JJ cord-015021-pol2qm74 42 14 communication communication NN cord-015021-pol2qm74 42 15 sessions session NNS cord-015021-pol2qm74 42 16 and and CC cord-015021-pol2qm74 42 17 posters poster NNS cord-015021-pol2qm74 42 18 , , , cord-015021-pol2qm74 42 19 which which WDT cord-015021-pol2qm74 42 20 will will MD cord-015021-pol2qm74 42 21 update update VB cord-015021-pol2qm74 42 22 the the DT cord-015021-pol2qm74 42 23 participants participant NNS cord-015021-pol2qm74 42 24 on on IN cord-015021-pol2qm74 42 25 a a DT cord-015021-pol2qm74 42 26 variety variety NN cord-015021-pol2qm74 42 27 of of IN cord-015021-pol2qm74 42 28 relevant relevant JJ cord-015021-pol2qm74 42 29 topics topic NNS cord-015021-pol2qm74 42 30 presented present VBN cord-015021-pol2qm74 42 31 by by IN cord-015021-pol2qm74 42 32 many many JJ cord-015021-pol2qm74 42 33 of of IN cord-015021-pol2qm74 42 34 the the DT cord-015021-pol2qm74 42 35 leading lead VBG cord-015021-pol2qm74 42 36 in in IN cord-015021-pol2qm74 42 37 - - HYPH cord-015021-pol2qm74 42 38 IV IV NNP cord-015021-pol2qm74 42 39 vestigators vestigator NNS cord-015021-pol2qm74 42 40 in in IN cord-015021-pol2qm74 42 41 these these DT cord-015021-pol2qm74 42 42 fields field NNS cord-015021-pol2qm74 42 43 . . . cord-015021-pol2qm74 43 1 Topics topic NNS cord-015021-pol2qm74 43 2 will will MD cord-015021-pol2qm74 43 3 range range VB cord-015021-pol2qm74 43 4 from from IN cord-015021-pol2qm74 43 5 molecular molecular JJ cord-015021-pol2qm74 43 6 mechanisms mechanism NNS cord-015021-pol2qm74 43 7 , , , cord-015021-pol2qm74 43 8 such such JJ cord-015021-pol2qm74 43 9 as as IN cord-015021-pol2qm74 43 10 signal signal NN cord-015021-pol2qm74 43 11 transduction transduction NN cord-015021-pol2qm74 43 12 , , , cord-015021-pol2qm74 43 13 through through IN cord-015021-pol2qm74 43 14 the the DT cord-015021-pol2qm74 43 15 explosive explosive JJ cord-015021-pol2qm74 43 16 growth growth NN cord-015021-pol2qm74 43 17 of of IN cord-015021-pol2qm74 43 18 information information NN cord-015021-pol2qm74 43 19 on on IN cord-015021-pol2qm74 43 20 the the DT cord-015021-pol2qm74 43 21 role role NN cord-015021-pol2qm74 43 22 of of IN cord-015021-pol2qm74 43 23 cytokines cytokine NNS cord-015021-pol2qm74 43 24 and and CC cord-015021-pol2qm74 43 25 pathophysiology pathophysiology NN cord-015021-pol2qm74 43 26 , , , cord-015021-pol2qm74 43 27 to to IN cord-015021-pol2qm74 43 28 practical practical JJ cord-015021-pol2qm74 43 29 considerations consideration NNS cord-015021-pol2qm74 43 30 in in IN cord-015021-pol2qm74 43 31 the the DT cord-015021-pol2qm74 43 32 design design NN cord-015021-pol2qm74 43 33 of of IN cord-015021-pol2qm74 43 34 immunomodulatory immunomodulatory JJ cord-015021-pol2qm74 43 35 therapeutic therapeutic JJ cord-015021-pol2qm74 43 36 regimens regimen NNS cord-015021-pol2qm74 43 37 . . . cord-015021-pol2qm74 44 1 These these DT cord-015021-pol2qm74 44 2 merely merely RB cord-015021-pol2qm74 44 3 touch touch VBP cord-015021-pol2qm74 44 4 on on IN cord-015021-pol2qm74 44 5 a a DT cord-015021-pol2qm74 44 6 few few JJ cord-015021-pol2qm74 44 7 areas area NNS cord-015021-pol2qm74 44 8 , , , cord-015021-pol2qm74 44 9 from from IN cord-015021-pol2qm74 44 10 the the DT cord-015021-pol2qm74 44 11 basic basic JJ cord-015021-pol2qm74 44 12 to to IN cord-015021-pol2qm74 44 13 the the DT cord-015021-pol2qm74 44 14 clinical clinical JJ cord-015021-pol2qm74 44 15 , , , cord-015021-pol2qm74 44 16 which which WDT cord-015021-pol2qm74 44 17 will will MD cord-015021-pol2qm74 44 18 be be VB cord-015021-pol2qm74 44 19 the the DT cord-015021-pol2qm74 44 20 subjects subject NNS cord-015021-pol2qm74 44 21 of of IN cord-015021-pol2qm74 44 22 those those DT cord-015021-pol2qm74 44 23 symposia symposium NNS cord-015021-pol2qm74 44 24 . . . cord-015021-pol2qm74 45 1 All all PDT cord-015021-pol2qm74 45 2 this this DT cord-015021-pol2qm74 45 3 information information NN cord-015021-pol2qm74 45 4 will will MD cord-015021-pol2qm74 45 5 fit fit VB cord-015021-pol2qm74 45 6 into into IN cord-015021-pol2qm74 45 7 the the DT cord-015021-pol2qm74 45 8 jigsaw jigsaw NN cord-015021-pol2qm74 45 9 of of IN cord-015021-pol2qm74 45 10 this this DT cord-015021-pol2qm74 45 11 exciting exciting JJ cord-015021-pol2qm74 45 12 area area NN cord-015021-pol2qm74 45 13 and and CC cord-015021-pol2qm74 45 14 its -PRON- PRP$ cord-015021-pol2qm74 45 15 stimulus stimulus NN cord-015021-pol2qm74 45 16 to to TO cord-015021-pol2qm74 45 17 further further JJ cord-015021-pol2qm74 45 18 research research NN cord-015021-pol2qm74 45 19 study study NN cord-015021-pol2qm74 45 20 . . . cord-015021-pol2qm74 46 1 This this DT cord-015021-pol2qm74 46 2 promises promise VBZ cord-015021-pol2qm74 46 3 to to TO cord-015021-pol2qm74 46 4 provide provide VB cord-015021-pol2qm74 46 5 an an DT cord-015021-pol2qm74 46 6 exciting exciting JJ cord-015021-pol2qm74 46 7 , , , cord-015021-pol2qm74 46 8 educational educational JJ cord-015021-pol2qm74 46 9 programme programme NN cord-015021-pol2qm74 46 10 with with IN cord-015021-pol2qm74 46 11 experts expert NNS cord-015021-pol2qm74 46 12 and and CC cord-015021-pol2qm74 46 13 participants participant NNS cord-015021-pol2qm74 46 14 from from IN cord-015021-pol2qm74 46 15 all all RB cord-015021-pol2qm74 46 16 over over IN cord-015021-pol2qm74 46 17 the the DT cord-015021-pol2qm74 46 18 world world NN cord-015021-pol2qm74 46 19 . . . cord-015021-pol2qm74 47 1 We -PRON- PRP cord-015021-pol2qm74 47 2 hope hope VBP cord-015021-pol2qm74 47 3 it -PRON- PRP cord-015021-pol2qm74 47 4 will will MD cord-015021-pol2qm74 47 5 set set VB cord-015021-pol2qm74 47 6 the the DT cord-015021-pol2qm74 47 7 stage stage NN cord-015021-pol2qm74 47 8 for for IN cord-015021-pol2qm74 47 9 many many JJ cord-015021-pol2qm74 47 10 years year NNS cord-015021-pol2qm74 47 11 to to TO cord-015021-pol2qm74 47 12 come come VB cord-015021-pol2qm74 47 13 and and CC cord-015021-pol2qm74 47 14 will will MD cord-015021-pol2qm74 47 15 increase increase VB cord-015021-pol2qm74 47 16 our -PRON- PRP$ cord-015021-pol2qm74 47 17 understanding understanding NN cord-015021-pol2qm74 47 18 of of IN cord-015021-pol2qm74 47 19 trauma trauma NN cord-015021-pol2qm74 47 20 , , , cord-015021-pol2qm74 47 21 shock shock NN cord-015021-pol2qm74 47 22 and and CC cord-015021-pol2qm74 47 23 sepsis sepsis NN cord-015021-pol2qm74 47 24 and and CC cord-015021-pol2qm74 47 25 help help VB cord-015021-pol2qm74 47 26 us -PRON- PRP cord-015021-pol2qm74 47 27 to to TO cord-015021-pol2qm74 47 28 provide provide VB cord-015021-pol2qm74 47 29 better well JJR cord-015021-pol2qm74 47 30 therapy therapy NN cord-015021-pol2qm74 47 31 for for IN cord-015021-pol2qm74 47 32 those those DT cord-015021-pol2qm74 47 33 of of IN cord-015021-pol2qm74 47 34 our -PRON- PRP$ cord-015021-pol2qm74 47 35 patients patient NNS cord-015021-pol2qm74 47 36 who who WP cord-015021-pol2qm74 47 37 are be VBP cord-015021-pol2qm74 47 38 affected affect VBN cord-015021-pol2qm74 47 39 by by IN cord-015021-pol2qm74 47 40 such such JJ cord-015021-pol2qm74 47 41 problems problem NNS cord-015021-pol2qm74 47 42 . . . cord-015021-pol2qm74 48 1 A. A. NNP cord-015021-pol2qm74 49 1 The the DT cord-015021-pol2qm74 49 2 clinical clinical JJ cord-015021-pol2qm74 49 3 syndrome syndrome NN cord-015021-pol2qm74 49 4 of of IN cord-015021-pol2qm74 49 5 MODS MODS NNP cord-015021-pol2qm74 49 6 versus versus IN cord-015021-pol2qm74 49 7 MOF MOF NNP cord-015021-pol2qm74 49 8 will will MD cord-015021-pol2qm74 49 9 be be VB cord-015021-pol2qm74 49 10 reviewed review VBN cord-015021-pol2qm74 49 11 in in IN cord-015021-pol2qm74 49 12 detail detail NN cord-015021-pol2qm74 49 13 by by IN cord-015021-pol2qm74 49 14 those those DT cord-015021-pol2qm74 49 15 who who WP cord-015021-pol2qm74 49 16 have have VBP cord-015021-pol2qm74 49 17 made make VBN cord-015021-pol2qm74 49 18 these these DT cord-015021-pol2qm74 49 19 proposals proposal NNS cord-015021-pol2qm74 49 20 . . . cord-015021-pol2qm74 50 1 B. B. NNP cord-015021-pol2qm74 51 1 An an DT cord-015021-pol2qm74 51 2 extensive extensive JJ cord-015021-pol2qm74 51 3 review review NN cord-015021-pol2qm74 51 4 of of IN cord-015021-pol2qm74 51 5 the the DT cord-015021-pol2qm74 51 6 design design NN cord-015021-pol2qm74 51 7 and and CC cord-015021-pol2qm74 51 8 interpretation interpretation NN cord-015021-pol2qm74 51 9 of of IN cord-015021-pol2qm74 51 10 clinical clinical JJ cord-015021-pol2qm74 51 11 trials trial NNS cord-015021-pol2qm74 51 12 in in IN cord-015021-pol2qm74 51 13 patients patient NNS cord-015021-pol2qm74 51 14 with with IN cord-015021-pol2qm74 51 15 shock shock NN cord-015021-pol2qm74 51 16 and and CC cord-015021-pol2qm74 51 17 injury injury NN cord-015021-pol2qm74 51 18 will will MD cord-015021-pol2qm74 51 19 be be VB cord-015021-pol2qm74 51 20 provided provide VBN cord-015021-pol2qm74 51 21 . . . cord-015021-pol2qm74 52 1 The the DT cord-015021-pol2qm74 52 2 reasons reason NNS cord-015021-pol2qm74 52 3 why why WRB cord-015021-pol2qm74 52 4 so so RB cord-015021-pol2qm74 52 5 many many JJ cord-015021-pol2qm74 52 6 clinical clinical JJ cord-015021-pol2qm74 52 7 studies study NNS cord-015021-pol2qm74 52 8 in in IN cord-015021-pol2qm74 52 9 the the DT cord-015021-pol2qm74 52 10 recent recent JJ cord-015021-pol2qm74 52 11 past past NN cord-015021-pol2qm74 52 12 have have VBP cord-015021-pol2qm74 52 13 been be VBN cord-015021-pol2qm74 52 14 negative negative JJ cord-015021-pol2qm74 52 15 will will MD cord-015021-pol2qm74 52 16 be be VB cord-015021-pol2qm74 52 17 reviewed review VBN cord-015021-pol2qm74 52 18 . . . cord-015021-pol2qm74 53 1 The the DT cord-015021-pol2qm74 53 2 therapeutic therapeutic JJ cord-015021-pol2qm74 53 3 strategies strategy NNS cord-015021-pol2qm74 53 4 that that WDT cord-015021-pol2qm74 53 5 are be VBP cord-015021-pol2qm74 53 6 being be VBG cord-015021-pol2qm74 53 7 developed develop VBN cord-015021-pol2qm74 53 8 for for IN cord-015021-pol2qm74 53 9 the the DT cord-015021-pol2qm74 53 10 treatment treatment NN cord-015021-pol2qm74 53 11 or or CC cord-015021-pol2qm74 53 12 prevention prevention NN cord-015021-pol2qm74 53 13 of of IN cord-015021-pol2qm74 53 14 MODS MODS NNP cord-015021-pol2qm74 53 15 or or CC cord-015021-pol2qm74 53 16 MOF MOF NNP cord-015021-pol2qm74 53 17 will will MD cord-015021-pol2qm74 53 18 be be VB cord-015021-pol2qm74 53 19 the the DT cord-015021-pol2qm74 53 20 subject subject NN cord-015021-pol2qm74 53 21 of of IN cord-015021-pol2qm74 53 22 another another DT cord-015021-pol2qm74 53 23 panel panel NN cord-015021-pol2qm74 53 24 discussion discussion NN cord-015021-pol2qm74 53 25 by by IN cord-015021-pol2qm74 53 26 experts expert NNS cord-015021-pol2qm74 53 27 who who WP cord-015021-pol2qm74 53 28 have have VBP cord-015021-pol2qm74 53 29 been be VBN cord-015021-pol2qm74 53 30 involved involve VBN cord-015021-pol2qm74 53 31 in in IN cord-015021-pol2qm74 53 32 and and CC cord-015021-pol2qm74 53 33 contributed contribute VBD cord-015021-pol2qm74 53 34 to to IN cord-015021-pol2qm74 53 35 this this DT cord-015021-pol2qm74 53 36 area area NN cord-015021-pol2qm74 53 37 . . . cord-015021-pol2qm74 54 1 A a DT cord-015021-pol2qm74 54 2 consensus consensus NN cord-015021-pol2qm74 54 3 conference conference NN cord-015021-pol2qm74 54 4 or or CC cord-015021-pol2qm74 54 5 controversy controversy NN cord-015021-pol2qm74 54 6 conference conference NN cord-015021-pol2qm74 54 7 will will MD cord-015021-pol2qm74 54 8 be be VB cord-015021-pol2qm74 54 9 presented present VBN cord-015021-pol2qm74 54 10 about about IN cord-015021-pol2qm74 54 11 various various JJ cord-015021-pol2qm74 54 12 aspects aspect NNS cord-015021-pol2qm74 54 13 of of IN cord-015021-pol2qm74 54 14 MODS mod NNS cord-015021-pol2qm74 54 15 or or CC cord-015021-pol2qm74 54 16 MOF MOF NNP cord-015021-pol2qm74 54 17 , , , cord-015021-pol2qm74 54 18 including include VBG cord-015021-pol2qm74 54 19 the the DT cord-015021-pol2qm74 54 20 benefits benefit NNS cord-015021-pol2qm74 54 21 of of IN cord-015021-pol2qm74 54 22 supernormal supernormal JJ cord-015021-pol2qm74 54 23 oxygen oxygen NN cord-015021-pol2qm74 54 24 delivery delivery NN cord-015021-pol2qm74 54 25 , , , cord-015021-pol2qm74 54 26 bacterial bacterial JJ cord-015021-pol2qm74 54 27 translocation translocation NN cord-015021-pol2qm74 54 28 , , , cord-015021-pol2qm74 54 29 parenteral parenteral JJ cord-015021-pol2qm74 54 30 nutrition nutrition NN cord-015021-pol2qm74 54 31 , , , cord-015021-pol2qm74 54 32 the the DT cord-015021-pol2qm74 54 33 immune immune JJ cord-015021-pol2qm74 54 34 response response NN cord-015021-pol2qm74 54 35 and and CC cord-015021-pol2qm74 54 36 other other JJ cord-015021-pol2qm74 54 37 aspects aspect NNS cord-015021-pol2qm74 54 38 . . . cord-015021-pol2qm74 55 1 The the DT cord-015021-pol2qm74 55 2 successes success NNS cord-015021-pol2qm74 55 3 and and CC cord-015021-pol2qm74 55 4 failures failure NNS cord-015021-pol2qm74 55 5 of of IN cord-015021-pol2qm74 55 6 completed complete VBN cord-015021-pol2qm74 55 7 clinical clinical JJ cord-015021-pol2qm74 55 8 trials trial NNS cord-015021-pol2qm74 55 9 will will MD cord-015021-pol2qm74 55 10 be be VB cord-015021-pol2qm74 55 11 presented present VBN cord-015021-pol2qm74 55 12 by by IN cord-015021-pol2qm74 55 13 those those DT cord-015021-pol2qm74 55 14 who who WP cord-015021-pol2qm74 55 15 are be VBP cord-015021-pol2qm74 55 16 involved involve VBN cord-015021-pol2qm74 55 17 in in IN cord-015021-pol2qm74 55 18 these these DT cord-015021-pol2qm74 55 19 clinical clinical JJ cord-015021-pol2qm74 55 20 trials trial NNS cord-015021-pol2qm74 55 21 , , , cord-015021-pol2qm74 55 22 with with IN cord-015021-pol2qm74 55 23 a a DT cord-015021-pol2qm74 55 24 refreshing refreshing JJ cord-015021-pol2qm74 55 25 review review NN cord-015021-pol2qm74 55 26 of of IN cord-015021-pol2qm74 55 27 the the DT cord-015021-pol2qm74 55 28 problems problem NNS cord-015021-pol2qm74 55 29 related relate VBN cord-015021-pol2qm74 55 30 to to IN cord-015021-pol2qm74 55 31 that that DT cord-015021-pol2qm74 55 32 injury injury NN cord-015021-pol2qm74 55 33 . . . cord-015021-pol2qm74 56 1 There there EX cord-015021-pol2qm74 56 2 will will MD cord-015021-pol2qm74 56 3 be be VB cord-015021-pol2qm74 56 4 late late JJ cord-015021-pol2qm74 56 5 news news NN cord-015021-pol2qm74 56 6 about about IN cord-015021-pol2qm74 56 7 studies study NNS cord-015021-pol2qm74 56 8 just just RB cord-015021-pol2qm74 56 9 being be VBG cord-015021-pol2qm74 56 10 completed complete VBN cord-015021-pol2qm74 56 11 at at IN cord-015021-pol2qm74 56 12 present present JJ cord-015021-pol2qm74 56 13 or or CC cord-015021-pol2qm74 56 14 after after IN cord-015021-pol2qm74 56 15 the the DT cord-015021-pol2qm74 56 16 beginning beginning NN cord-015021-pol2qm74 56 17 of of IN cord-015021-pol2qm74 56 18 1994 1994 CD cord-015021-pol2qm74 56 19 and and CC cord-015021-pol2qm74 56 20 where where WRB cord-015021-pol2qm74 56 21 they -PRON- PRP cord-015021-pol2qm74 56 22 stand stand VBP cord-015021-pol2qm74 56 23 . . . cord-015021-pol2qm74 57 1 C. C. NNP cord-015021-pol2qm74 58 1 The the DT cord-015021-pol2qm74 58 2 mechanisms mechanism NNS cord-015021-pol2qm74 58 3 and and CC cord-015021-pol2qm74 58 4 biochemical biochemical JJ cord-015021-pol2qm74 58 5 profiles profile NNS cord-015021-pol2qm74 58 6 of of IN cord-015021-pol2qm74 58 7 specific specific JJ cord-015021-pol2qm74 58 8 organ organ NN cord-015021-pol2qm74 58 9 dysfunction dysfunction NN cord-015021-pol2qm74 58 10 or or CC cord-015021-pol2qm74 58 11 failure failure NN cord-015021-pol2qm74 58 12 will will MD cord-015021-pol2qm74 58 13 be be VB cord-015021-pol2qm74 58 14 reviewed review VBN cord-015021-pol2qm74 58 15 . . . cord-015021-pol2qm74 59 1 What what WP cord-015021-pol2qm74 59 2 are be VBP cord-015021-pol2qm74 59 3 the the DT cord-015021-pol2qm74 59 4 definitions definition NNS cord-015021-pol2qm74 59 5 ? ? . cord-015021-pol2qm74 60 1 What what WP cord-015021-pol2qm74 60 2 are be VBP cord-015021-pol2qm74 60 3 the the DT cord-015021-pol2qm74 60 4 mechanisms mechanism NNS cord-015021-pol2qm74 60 5 ? ? . cord-015021-pol2qm74 61 1 How how WRB cord-015021-pol2qm74 61 2 can can MD cord-015021-pol2qm74 61 3 organ organ NN cord-015021-pol2qm74 61 4 dysfunction dysfunction NN cord-015021-pol2qm74 61 5 and/or and/or CC cord-015021-pol2qm74 61 6 failure failure NN cord-015021-pol2qm74 61 7 be be VB cord-015021-pol2qm74 61 8 defined define VBN cord-015021-pol2qm74 61 9 ? ? . cord-015021-pol2qm74 62 1 An an DT cord-015021-pol2qm74 62 2 extensive extensive JJ cord-015021-pol2qm74 62 3 review review NN cord-015021-pol2qm74 62 4 of of IN cord-015021-pol2qm74 62 5 the the DT cord-015021-pol2qm74 62 6 biological biological JJ cord-015021-pol2qm74 62 7 mechanisms mechanism NNS cord-015021-pol2qm74 62 8 involved involve VBN cord-015021-pol2qm74 62 9 in in IN cord-015021-pol2qm74 62 10 production production NN cord-015021-pol2qm74 62 11 of of IN cord-015021-pol2qm74 62 12 injury injury NN cord-015021-pol2qm74 62 13 by by IN cord-015021-pol2qm74 62 14 mediators mediator NNS cord-015021-pol2qm74 62 15 will will MD cord-015021-pol2qm74 62 16 be be VB cord-015021-pol2qm74 62 17 presented present VBN cord-015021-pol2qm74 62 18 . . . cord-015021-pol2qm74 63 1 A a DT cord-015021-pol2qm74 63 2 session session NN cord-015021-pol2qm74 63 3 will will MD cord-015021-pol2qm74 63 4 be be VB cord-015021-pol2qm74 63 5 devoted devote VBN cord-015021-pol2qm74 63 6 to to IN cord-015021-pol2qm74 63 7 how how WRB cord-015021-pol2qm74 63 8 future future JJ cord-015021-pol2qm74 63 9 ongoing ongoing JJ cord-015021-pol2qm74 63 10 trials trial NNS cord-015021-pol2qm74 63 11 might may MD cord-015021-pol2qm74 63 12 be be VB cord-015021-pol2qm74 63 13 better well RBR cord-015021-pol2qm74 63 14 designed design VBN cord-015021-pol2qm74 63 15 and and CC cord-015021-pol2qm74 63 16 what what WP cord-015021-pol2qm74 63 17 can can MD cord-015021-pol2qm74 63 18 be be VB cord-015021-pol2qm74 63 19 done do VBN cord-015021-pol2qm74 63 20 about about IN cord-015021-pol2qm74 63 21 the the DT cord-015021-pol2qm74 63 22 studies study NNS cord-015021-pol2qm74 63 23 recently recently RB cord-015021-pol2qm74 63 24 completed complete VBD cord-015021-pol2qm74 63 25 , , , cord-015021-pol2qm74 63 26 many many JJ cord-015021-pol2qm74 63 27 of of IN cord-015021-pol2qm74 63 28 which which WDT cord-015021-pol2qm74 63 29 are be VBP cord-015021-pol2qm74 63 30 negative negative JJ cord-015021-pol2qm74 63 31 . . . cord-015021-pol2qm74 64 1 D. D. NNP cord-015021-pol2qm74 65 1 The the DT cord-015021-pol2qm74 65 2 immunological immunological JJ cord-015021-pol2qm74 65 3 or or CC cord-015021-pol2qm74 65 4 inflammatory inflammatory JJ cord-015021-pol2qm74 65 5 pathways pathway NNS cord-015021-pol2qm74 65 6 resulting result VBG cord-015021-pol2qm74 65 7 in in IN cord-015021-pol2qm74 65 8 organ organ NN cord-015021-pol2qm74 65 9 injury injury NN cord-015021-pol2qm74 65 10 will will MD cord-015021-pol2qm74 65 11 be be VB cord-015021-pol2qm74 65 12 reviewed review VBN cord-015021-pol2qm74 65 13 in in IN cord-015021-pol2qm74 65 14 detail detail NN cord-015021-pol2qm74 65 15 in in IN cord-015021-pol2qm74 65 16 presentations presentation NNS cord-015021-pol2qm74 65 17 and and CC cord-015021-pol2qm74 65 18 a a DT cord-015021-pol2qm74 65 19 panel panel NN cord-015021-pol2qm74 65 20 discussion discussion NN cord-015021-pol2qm74 65 21 . . . cord-015021-pol2qm74 66 1 We -PRON- PRP cord-015021-pol2qm74 66 2 look look VBP cord-015021-pol2qm74 66 3 forward forward RB cord-015021-pol2qm74 66 4 to to IN cord-015021-pol2qm74 66 5 welcoming welcome VBG cord-015021-pol2qm74 66 6 you -PRON- PRP cord-015021-pol2qm74 66 7 to to IN cord-015021-pol2qm74 66 8 an an DT cord-015021-pol2qm74 66 9 exciting exciting JJ cord-015021-pol2qm74 66 10 and and CC cord-015021-pol2qm74 66 11 rewarding rewarding JJ cord-015021-pol2qm74 66 12 conference conference NN cord-015021-pol2qm74 66 13 , , , cord-015021-pol2qm74 66 14 which which WDT cord-015021-pol2qm74 66 15 undoubtedly undoubtedly RB cord-015021-pol2qm74 66 16 possesses possess VBZ cord-015021-pol2qm74 66 17 the the DT cord-015021-pol2qm74 66 18 potential potential NN cord-015021-pol2qm74 66 19 to to TO cord-015021-pol2qm74 66 20 become become VB cord-015021-pol2qm74 66 21 a a DT cord-015021-pol2qm74 66 22 landmark landmark JJ cord-015021-pol2qm74 66 23 event event NN cord-015021-pol2qm74 66 24 and and CC cord-015021-pol2qm74 66 25 major major JJ cord-015021-pol2qm74 66 26 reference reference NN cord-015021-pol2qm74 66 27 point point NN cord-015021-pol2qm74 66 28 for for IN cord-015021-pol2qm74 66 29 any any DT cord-015021-pol2qm74 66 30 scientific scientific JJ cord-015021-pol2qm74 66 31 discussion discussion NN cord-015021-pol2qm74 66 32 about about IN cord-015021-pol2qm74 66 33 the the DT cord-015021-pol2qm74 66 34 complex complex NN cord-015021-pol2qm74 66 35 of of IN cord-015021-pol2qm74 66 36 host host NN cord-015021-pol2qm74 66 37 defense defense NN cord-015021-pol2qm74 66 38 dysfunctions dysfunction NNS cord-015021-pol2qm74 66 39 following follow VBG cord-015021-pol2qm74 66 40 trauma trauma NN cord-015021-pol2qm74 66 41 , , , cord-015021-pol2qm74 66 42 shock shock NN cord-015021-pol2qm74 66 43 and and CC cord-015021-pol2qm74 66 44 sepsis sepsis NN cord-015021-pol2qm74 66 45 . . . cord-015021-pol2qm74 67 1 Studies study NNS cord-015021-pol2qm74 67 2 over over IN cord-015021-pol2qm74 67 3 the the DT cord-015021-pol2qm74 67 4 past past JJ cord-015021-pol2qm74 67 5 25 25 CD cord-015021-pol2qm74 67 6 years year NNS cord-015021-pol2qm74 67 7 have have VBP cord-015021-pol2qm74 67 8 established establish VBN cord-015021-pol2qm74 67 9 that that IN cord-015021-pol2qm74 67 10 the the DT cord-015021-pol2qm74 67 11 contact contact NN cord-015021-pol2qm74 67 12 system system NN cord-015021-pol2qm74 67 13 , , , cord-015021-pol2qm74 67 14 which which WDT cord-015021-pol2qm74 67 15 forms form VBZ cord-015021-pol2qm74 67 16 bradykin/~ bradykin/~ CD cord-015021-pol2qm74 67 17 , , , cord-015021-pol2qm74 67 18 is be VBZ cord-015021-pol2qm74 67 19 gax gax NNP cord-015021-pol2qm74 67 20 important important JJ cord-015021-pol2qm74 67 21 mediator mediator NN cord-015021-pol2qm74 67 22 in in IN cord-015021-pol2qm74 67 23 hypotensive hypotensive JJ cord-015021-pol2qm74 67 24 septicemia septicemia NN cord-015021-pol2qm74 67 25 . . . cord-015021-pol2qm74 68 1 In in IN cord-015021-pol2qm74 68 2 addition addition NN cord-015021-pol2qm74 68 3 to to IN cord-015021-pol2qm74 68 4 hradyk{nln hradyk{nln NN cord-015021-pol2qm74 68 5 , , , cord-015021-pol2qm74 68 6 another another DT cord-015021-pol2qm74 68 7 product product NN cord-015021-pol2qm74 68 8 of of IN cord-015021-pol2qm74 68 9 the the DT cord-015021-pol2qm74 68 10 contact contact NN cord-015021-pol2qm74 68 11 system system NN cord-015021-pol2qm74 68 12 , , , cord-015021-pol2qm74 68 13 kaIlikrein kaIlikrein NNP cord-015021-pol2qm74 68 14 , , , cord-015021-pol2qm74 68 15 can can MD cord-015021-pol2qm74 68 16 mediate mediate VB cord-015021-pol2qm74 68 17 inflammation inflammation NN cord-015021-pol2qm74 68 18 by by IN cord-015021-pol2qm74 68 19 virtue virtue NN cord-015021-pol2qm74 68 20 of of IN cord-015021-pol2qm74 68 21 its -PRON- PRP$ cord-015021-pol2qm74 68 22 chemotaetic chemotaetic JJ cord-015021-pol2qm74 68 23 mad mad JJ cord-015021-pol2qm74 68 24 neutrophJ neutrophJ NNP cord-015021-pol2qm74 68 25 / / SYM cord-015021-pol2qm74 68 26 activating activate VBG cord-015021-pol2qm74 68 27 properties property NNS cord-015021-pol2qm74 68 28 . . . cord-015021-pol2qm74 69 1 Using use VBG cord-015021-pol2qm74 69 2 functional functional JJ cord-015021-pol2qm74 69 3 and and CC cord-015021-pol2qm74 69 4 immunochemical immunochemical JJ cord-015021-pol2qm74 69 5 tech~2ques tech~2ques NNP cord-015021-pol2qm74 69 6 , , , cord-015021-pol2qm74 69 7 we -PRON- PRP cord-015021-pol2qm74 69 8 have have VBP cord-015021-pol2qm74 69 9 demonstrated demonstrate VBN cord-015021-pol2qm74 69 10 activation activation NN cord-015021-pol2qm74 69 11 of of IN cord-015021-pol2qm74 69 12 the the DT cord-015021-pol2qm74 69 13 contact contact NN cord-015021-pol2qm74 69 14 system system NN cord-015021-pol2qm74 69 15 in in IN cord-015021-pol2qm74 69 16 the the DT cord-015021-pol2qm74 69 17 adult adult NN cord-015021-pol2qm74 69 18 respiratory respiratory JJ cord-015021-pol2qm74 69 19 distress distress NN cord-015021-pol2qm74 69 20 syndrome syndrome NN cord-015021-pol2qm74 69 21 in in IN cord-015021-pol2qm74 69 22 typhoid typhoid NN cord-015021-pol2qm74 69 23 fever fever NN cord-015021-pol2qm74 69 24 and and CC cord-015021-pol2qm74 69 25 clin clin NNP cord-015021-pol2qm74 69 26 / / SYM cord-015021-pol2qm74 69 27 cal cal NN cord-015021-pol2qm74 69 28 sepsis sepsis NN cord-015021-pol2qm74 69 29 . . . cord-015021-pol2qm74 70 1 We -PRON- PRP cord-015021-pol2qm74 70 2 have have VBP cord-015021-pol2qm74 70 3 also also RB cord-015021-pol2qm74 70 4 been be VBN cord-015021-pol2qm74 70 5 able able JJ cord-015021-pol2qm74 70 6 to to TO cord-015021-pol2qm74 70 7 inhibit inhibit VB cord-015021-pol2qm74 70 8 the the DT cord-015021-pol2qm74 70 9 hypotension hypotension NN cord-015021-pol2qm74 70 10 but but CC cord-015021-pol2qm74 70 11 not not RB cord-015021-pol2qm74 70 12 the the DT cord-015021-pol2qm74 70 13 disseminated disseminate VBN cord-015021-pol2qm74 70 14 intravaseular intravaseular JJ cord-015021-pol2qm74 70 15 coagulation coagulation NN cord-015021-pol2qm74 70 16 in in IN cord-015021-pol2qm74 70 17 a a DT cord-015021-pol2qm74 70 18 model model NN cord-015021-pol2qm74 70 19 of of IN cord-015021-pol2qm74 70 20 primate primate JJ cord-015021-pol2qm74 70 21 sepsis sepsis NN cord-015021-pol2qm74 70 22 by by IN cord-015021-pol2qm74 70 23 the the DT cord-015021-pol2qm74 70 24 use use NN cord-015021-pol2qm74 70 25 of of IN cord-015021-pol2qm74 70 26 a a DT cord-015021-pol2qm74 70 27 monoclonal monoclonal JJ cord-015021-pol2qm74 70 28 antibody antibody NN cord-015021-pol2qm74 70 29 directed direct VBD cord-015021-pol2qm74 70 30 agsi agsi NNP cord-015021-pol2qm74 70 31 ~ ~ NFP cord-015021-pol2qm74 70 32 st st NNP cord-015021-pol2qm74 70 33 factor factor NNP cord-015021-pol2qm74 70 34 XII XII NNP cord-015021-pol2qm74 70 35 , , , cord-015021-pol2qm74 70 36 the the DT cord-015021-pol2qm74 70 37 initiating initiate VBG cord-015021-pol2qm74 70 38 protein protein NN cord-015021-pol2qm74 70 39 of of IN cord-015021-pol2qm74 70 40 the the DT cord-015021-pol2qm74 70 41 contact contact NN cord-015021-pol2qm74 70 42 system system NN cord-015021-pol2qm74 70 43 , , , cord-015021-pol2qm74 70 44 in in IN cord-015021-pol2qm74 70 45 volunteers volunteer NNS cord-015021-pol2qm74 70 46 given give VBN cord-015021-pol2qm74 70 47 E. E. NNP cord-015021-pol2qm74 70 48 coil coil NN cord-015021-pol2qm74 70 49 endotoxin endotoxin NN cord-015021-pol2qm74 70 50 , , , cord-015021-pol2qm74 70 51 who who WP cord-015021-pol2qm74 70 52 did do VBD cord-015021-pol2qm74 70 53 not not RB cord-015021-pol2qm74 70 54 develop develop VB cord-015021-pol2qm74 70 55 hypotension hypotension NN cord-015021-pol2qm74 70 56 , , , cord-015021-pol2qm74 70 57 we -PRON- PRP cord-015021-pol2qm74 70 58 were be VBD cord-015021-pol2qm74 70 59 also also RB cord-015021-pol2qm74 70 60 able able JJ cord-015021-pol2qm74 70 61 to to TO cord-015021-pol2qm74 70 62 demonstrate demonstrate VB cord-015021-pol2qm74 70 63 activation activation NN cord-015021-pol2qm74 70 64 of of IN cord-015021-pol2qm74 70 65 the the DT cord-015021-pol2qm74 70 66 contact contact NN cord-015021-pol2qm74 70 67 system system NN cord-015021-pol2qm74 70 68 with with IN cord-015021-pol2qm74 70 69 a a DT cord-015021-pol2qm74 70 70 rise rise NN cord-015021-pol2qm74 70 71 of of IN cord-015021-pol2qm74 70 72 alpha-2macrogiebulin alpha-2macrogiebulin NN cord-015021-pol2qm74 70 73 - - HYPH cord-015021-pol2qm74 70 74 kalllkrein kalllkrein NNP cord-015021-pol2qm74 70 75 complex complex NN cord-015021-pol2qm74 70 76 . . . cord-015021-pol2qm74 71 1 We -PRON- PRP cord-015021-pol2qm74 71 2 have have VBP cord-015021-pol2qm74 71 3 also also RB cord-015021-pol2qm74 71 4 examined examine VBN cord-015021-pol2qm74 71 5 , , , cord-015021-pol2qm74 71 6 J~ J~ `` cord-015021-pol2qm74 71 7 an an DT cord-015021-pol2qm74 71 8 i i NN cord-015021-pol2qm74 71 9 ~ ~ NFP cord-015021-pol2qm74 71 10 tensive tensive NNP cord-015021-pol2qm74 71 11 care care NN cord-015021-pol2qm74 71 12 situation situation NN cord-015021-pol2qm74 71 13 , , , cord-015021-pol2qm74 71 14 patients patient NNS cord-015021-pol2qm74 71 15 with with IN cord-015021-pol2qm74 71 16 SIRS SIRS NNP cord-015021-pol2qm74 71 17 . . . cord-015021-pol2qm74 72 1 We -PRON- PRP cord-015021-pol2qm74 72 2 found find VBD cord-015021-pol2qm74 72 3 that that IN cord-015021-pol2qm74 72 4 serial serial JJ cord-015021-pol2qm74 72 5 measuremezzts measuremezzt NNS cord-015021-pol2qm74 72 6 of of IN cord-015021-pol2qm74 72 7 the the DT cord-015021-pol2qm74 72 8 contact contact NN cord-015021-pol2qm74 72 9 system system NN cord-015021-pol2qm74 72 10 were be VBD cord-015021-pol2qm74 72 11 useful useful JJ cord-015021-pol2qm74 72 12 in in IN cord-015021-pol2qm74 72 13 eva eva NNP cord-015021-pol2qm74 73 1 ~u ~u NNP cord-015021-pol2qm74 73 2 ~ ~ NFP cord-015021-pol2qm74 73 3 ting ting NNP cord-015021-pol2qm74 73 4 prognosis+ prognosis+ NNP cord-015021-pol2qm74 73 5 These these DT cord-015021-pol2qm74 73 6 studies study NNS cord-015021-pol2qm74 73 7 suggest suggest VBP cord-015021-pol2qm74 73 8 that that IN cord-015021-pol2qm74 73 9 inhibition inhibition NN cord-015021-pol2qm74 73 10 of of IN cord-015021-pol2qm74 73 11 kalllkrein kalllkrein NNP cord-015021-pol2qm74 73 12 a a DT cord-015021-pol2qm74 73 13 ~ ~ NFP cord-015021-pol2qm74 73 14 d d NN cord-015021-pol2qm74 73 15 l l NN cord-015021-pol2qm74 73 16 e e NN cord-015021-pol2qm74 73 17 r r NN cord-015021-pol2qm74 73 18 bradykinin bradykinin NN cord-015021-pol2qm74 73 19 actions action NNS cord-015021-pol2qm74 73 20 might may MD cord-015021-pol2qm74 73 21 be be VB cord-015021-pol2qm74 73 22 useful useful JJ cord-015021-pol2qm74 73 23 i~ i~ CD cord-015021-pol2qm74 73 24 obviating obviate VBG cord-015021-pol2qm74 73 25 many many JJ cord-015021-pol2qm74 73 26 .of .of . cord-015021-pol2qm74 74 1 the the DT cord-015021-pol2qm74 74 2 features feature NNS cord-015021-pol2qm74 74 3 seen see VBN cord-015021-pol2qm74 74 4 in in IN cord-015021-pol2qm74 74 5 sepsis sepsis NN cord-015021-pol2qm74 74 6 and and CC cord-015021-pol2qm74 74 7 septic septic JJ cord-015021-pol2qm74 74 8 shock shock NN cord-015021-pol2qm74 74 9 . . . cord-015021-pol2qm74 75 1 Dextran dextran NN cord-015021-pol2qm74 75 2 sulfate sulfate NN cord-015021-pol2qm74 75 3 ( ( -LRB- cord-015021-pol2qm74 75 4 DXS DXS NNP cord-015021-pol2qm74 75 5 ) ) -RRB- cord-015021-pol2qm74 75 6 activates activate VBZ cord-015021-pol2qm74 75 7 the the DT cord-015021-pol2qm74 75 8 contact contact NN cord-015021-pol2qm74 75 9 system system NN cord-015021-pol2qm74 75 10 and and CC cord-015021-pol2qm74 75 11 , , , cord-015021-pol2qm74 75 12 in in IN cord-015021-pol2qm74 75 13 vivo vivo NN cord-015021-pol2qm74 75 14 , , , cord-015021-pol2qm74 75 15 produces produce VBZ cord-015021-pol2qm74 75 16 transient transient JJ cord-015021-pol2qm74 75 17 hypotension hypotension NN cord-015021-pol2qm74 75 18 . . . cord-015021-pol2qm74 76 1 In in IN cord-015021-pol2qm74 76 2 order order NN cord-015021-pol2qm74 76 3 to to TO cord-015021-pol2qm74 76 4 better better RB cord-015021-pol2qm74 76 5 define define VB cord-015021-pol2qm74 76 6 the the DT cord-015021-pol2qm74 76 7 mechanisms mechanism NNS cord-015021-pol2qm74 76 8 underlying underlie VBG cord-015021-pol2qm74 76 9 the the DT cord-015021-pol2qm74 76 10 DXS DXS NNP cord-015021-pol2qm74 76 11 - - HYPH cord-015021-pol2qm74 76 12 induced induce VBN cord-015021-pol2qm74 76 13 hypotension hypotension NN cord-015021-pol2qm74 76 14 , , , cord-015021-pol2qm74 76 15 we -PRON- PRP cord-015021-pol2qm74 76 16 investigated investigate VBD cord-015021-pol2qm74 76 17 the the DT cord-015021-pol2qm74 76 18 effects effect NNS cord-015021-pol2qm74 76 19 of of IN cord-015021-pol2qm74 76 20 either either CC cord-015021-pol2qm74 76 21 the the DT cord-015021-pol2qm74 76 22 plasma plasma NN cord-015021-pol2qm74 76 23 kallikrein kallikrein NNP cord-015021-pol2qm74 76 24 inhibitor inhibitor NNP cord-015021-pol2qm74 76 25 , , , cord-015021-pol2qm74 76 26 des des NNP cord-015021-pol2qm74 76 27 - - HYPH cord-015021-pol2qm74 76 28 Pro2-iArg]5]aprotinin Pro2-iArg]5]aprotinin NNP cord-015021-pol2qm74 76 29 ( ( -LRB- cord-015021-pol2qm74 76 30 BAY BAY NNP cord-015021-pol2qm74 76 31 4620 4620 CD cord-015021-pol2qm74 76 32 ) ) -RRB- cord-015021-pol2qm74 76 33 or or CC cord-015021-pol2qm74 76 34 the the DT cord-015021-pol2qm74 76 35 B2 B2 NNP cord-015021-pol2qm74 76 36 kinin kinin NNP cord-015021-pol2qm74 76 37 antagonist antagonist NN cord-015021-pol2qm74 76 38 , , , cord-015021-pol2qm74 76 39 Hoe hoe VB cord-015021-pol2qm74 76 40 140 140 CD cord-015021-pol2qm74 76 41 on on IN cord-015021-pol2qm74 76 42 the the DT cord-015021-pol2qm74 76 43 hypotensive hypotensive JJ cord-015021-pol2qm74 76 44 response response NN cord-015021-pol2qm74 76 45 to to IN cord-015021-pol2qm74 76 46 DXS DXS NNP cord-015021-pol2qm74 76 47 . . . cord-015021-pol2qm74 77 1 In in IN cord-015021-pol2qm74 77 2 the the DT cord-015021-pol2qm74 77 3 first first JJ cord-015021-pol2qm74 77 4 study study NN cord-015021-pol2qm74 77 5 , , , cord-015021-pol2qm74 77 6 anesthetized anesthetize VBN cord-015021-pol2qm74 77 7 miniature miniature JJ cord-015021-pol2qm74 77 8 pigs pig NNS cord-015021-pol2qm74 77 9 ( ( -LRB- cord-015021-pol2qm74 77 10 5 5 CD cord-015021-pol2qm74 77 11 pigs pig NNS cord-015021-pol2qm74 77 12 / / SYM cord-015021-pol2qm74 77 13 group group NN cord-015021-pol2qm74 77 14 , , , cord-015021-pol2qm74 77 15 randomly randomly RB cord-015021-pol2qm74 77 16 assigned assign VBD cord-015021-pol2qm74 77 17 ) ) -RRB- cord-015021-pol2qm74 77 18 were be VBD cord-015021-pol2qm74 77 19 given give VBN cord-015021-pol2qm74 77 20 one one CD cord-015021-pol2qm74 77 21 of of IN cord-015021-pol2qm74 77 22 the the DT cord-015021-pol2qm74 77 23 following following JJ cord-015021-pol2qm74 77 24 treatment treatment NN cord-015021-pol2qm74 77 25 protocols protocol NNS cord-015021-pol2qm74 77 26 : : : cord-015021-pol2qm74 77 27 1 1 LS cord-015021-pol2qm74 77 28 ) ) -RRB- cord-015021-pol2qm74 77 29 DXS DXS NNP cord-015021-pol2qm74 77 30 ( ( -LRB- cord-015021-pol2qm74 77 31 5 5 CD cord-015021-pol2qm74 77 32 mg mg NNP cord-015021-pol2qm74 77 33 / / SYM cord-015021-pol2qm74 77 34 kg kg NNP cord-015021-pol2qm74 77 35 ) ) -RRB- cord-015021-pol2qm74 77 36 , , , cord-015021-pol2qm74 77 37 2 2 CD cord-015021-pol2qm74 77 38 - - SYM cord-015021-pol2qm74 77 39 5 5 CD cord-015021-pol2qm74 77 40 ) ) -RRB- cord-015021-pol2qm74 77 41 DXS DXS NNP cord-015021-pol2qm74 77 42 plus plus CC cord-015021-pol2qm74 77 43 BAY BAY NNP cord-015021-pol2qm74 77 44 4620 4620 CD cord-015021-pol2qm74 77 45 ( ( -LRB- cord-015021-pol2qm74 77 46 45 45 CD cord-015021-pol2qm74 77 47 , , , cord-015021-pol2qm74 77 48 90 90 CD cord-015021-pol2qm74 77 49 , , , cord-015021-pol2qm74 77 50 180 180 CD cord-015021-pol2qm74 77 51 , , , cord-015021-pol2qm74 77 52 or or CC cord-015021-pol2qm74 77 53 360 360 CD cord-015021-pol2qm74 77 54 rag rag NN cord-015021-pol2qm74 77 55 ) ) -RRB- cord-015021-pol2qm74 77 56 , , , cord-015021-pol2qm74 77 57 or or CC cord-015021-pol2qm74 77 58 6 6 CD cord-015021-pol2qm74 77 59 ) ) -RRB- cord-015021-pol2qm74 77 60 saline saline NN cord-015021-pol2qm74 77 61 . . . cord-015021-pol2qm74 78 1 DXS DXS NNP cord-015021-pol2qm74 78 2 alone alone RB cord-015021-pol2qm74 78 3 produced produce VBD cord-015021-pol2qm74 78 4 a a DT cord-015021-pol2qm74 78 5 profound profound JJ cord-015021-pol2qm74 78 6 but but CC cord-015021-pol2qm74 78 7 transient transient JJ cord-015021-pol2qm74 78 8 systemic systemic JJ cord-015021-pol2qm74 78 9 arterial arterial JJ cord-015021-pol2qm74 78 10 hypotension hypotension NN cord-015021-pol2qm74 78 11 with with IN cord-015021-pol2qm74 78 12 a a DT cord-015021-pol2qm74 78 13 corresponding corresponding JJ cord-015021-pol2qm74 78 14 reduction reduction NN cord-015021-pol2qm74 78 15 in in IN cord-015021-pol2qm74 78 16 plasma plasma NN cord-015021-pol2qm74 78 17 kinin kinin NN cord-015021-pol2qm74 78 18 - - HYPH cord-015021-pol2qm74 78 19 containing contain VBG cord-015021-pol2qm74 78 20 kininogen kininogen NNP cord-015021-pol2qm74 78 21 . . . cord-015021-pol2qm74 79 1 Circulating circulate VBG cord-015021-pol2qm74 79 2 kinin kinin NN cord-015021-pol2qm74 79 3 levels level NNS cord-015021-pol2qm74 79 4 , , , cord-015021-pol2qm74 79 5 complement complement NN cord-015021-pol2qm74 79 6 fragment fragment NN cord-015021-pol2qm74 79 7 C3adesArg c3adesarg NN cord-015021-pol2qm74 79 8 and and CC cord-015021-pol2qm74 79 9 fibrin fibrin NN cord-015021-pol2qm74 79 10 mom)mer mom)mer NNP cord-015021-pol2qm74 79 11 were be VBD cord-015021-pol2qm74 79 12 all all RB cord-015021-pol2qm74 79 13 increased increase VBN cord-015021-pol2qm74 79 14 . . . cord-015021-pol2qm74 80 1 BAY BAY NNP cord-015021-pol2qm74 80 2 4620 4620 CD cord-015021-pol2qm74 80 3 produced produce VBD cord-015021-pol2qm74 80 4 a a DT cord-015021-pol2qm74 80 5 dose dose NN cord-015021-pol2qm74 80 6 - - HYPH cord-015021-pol2qm74 80 7 dependent dependent JJ cord-015021-pol2qm74 80 8 delay delay NN cord-015021-pol2qm74 80 9 or or CC cord-015021-pol2qm74 80 10 attenuation attenuation NN cord-015021-pol2qm74 80 11 in in IN cord-015021-pol2qm74 80 12 these these DT cord-015021-pol2qm74 80 13 effects effect NNS cord-015021-pol2qm74 80 14 with with IN cord-015021-pol2qm74 80 15 the the DT cord-015021-pol2qm74 80 16 highest high JJS cord-015021-pol2qm74 80 17 dose dose NN cord-015021-pol2qm74 80 18 completely completely RB cord-015021-pol2qm74 80 19 blocking block VBG cord-015021-pol2qm74 80 20 DXS DXS NNP cord-015021-pol2qm74 80 21 - - HYPH cord-015021-pol2qm74 80 22 induced induce VBN cord-015021-pol2qm74 80 23 hypotension hypotension NN cord-015021-pol2qm74 80 24 and and CC cord-015021-pol2qm74 80 25 elevations elevation NNS cord-015021-pol2qm74 80 26 of of IN cord-015021-pol2qm74 80 27 kinin kinin NNP cord-015021-pol2qm74 80 28 , , , cord-015021-pol2qm74 80 29 C3adesArg c3adesarg NN cord-015021-pol2qm74 80 30 and and CC cord-015021-pol2qm74 80 31 fibrin fibrin NN cord-015021-pol2qm74 80 32 monomer monomer NN cord-015021-pol2qm74 80 33 levels level NNS cord-015021-pol2qm74 80 34 . . . cord-015021-pol2qm74 81 1 Thus thus RB cord-015021-pol2qm74 81 2 , , , cord-015021-pol2qm74 81 3 the the DT cord-015021-pol2qm74 81 4 effects effect NNS cord-015021-pol2qm74 81 5 of of IN cord-015021-pol2qm74 81 6 DXS DXS NNP cord-015021-pol2qm74 81 7 are be VBP cord-015021-pol2qm74 81 8 solely solely RB cord-015021-pol2qm74 81 9 dependent dependent JJ cord-015021-pol2qm74 81 10 on on IN cord-015021-pol2qm74 81 11 contact contact NN cord-015021-pol2qm74 81 12 system system NN cord-015021-pol2qm74 81 13 activation activation NN cord-015021-pol2qm74 81 14 and and CC cord-015021-pol2qm74 81 15 this this DT cord-015021-pol2qm74 81 16 activation activation NN cord-015021-pol2qm74 81 17 is be VBZ cord-015021-pol2qm74 81 18 sensitive sensitive JJ cord-015021-pol2qm74 81 19 to to IN cord-015021-pol2qm74 81 20 BAY BAY NNP cord-015021-pol2qm74 81 21 4620 4620 CD cord-015021-pol2qm74 81 22 . . . cord-015021-pol2qm74 82 1 llowev~:r llowev~:r NNP cord-015021-pol2qm74 82 2 , , , cord-015021-pol2qm74 82 3 contact contact NN cord-015021-pol2qm74 82 4 system system NN cord-015021-pol2qm74 82 5 activation activation NN cord-015021-pol2qm74 82 6 is be VBZ cord-015021-pol2qm74 82 7 known know VBN cord-015021-pol2qm74 82 8 to to TO cord-015021-pol2qm74 82 9 produce produce VB cord-015021-pol2qm74 82 10 changes change NNS cord-015021-pol2qm74 82 11 in in IN cord-015021-pol2qm74 82 12 a a DT cord-015021-pol2qm74 82 13 variety variety NN cord-015021-pol2qm74 82 14 of of IN cord-015021-pol2qm74 82 15 vasoactive vasoactive JJ cord-015021-pol2qm74 82 16 mediators mediator NNS cord-015021-pol2qm74 82 17 , , , cord-015021-pol2qm74 82 18 all all DT cord-015021-pol2qm74 82 19 of of IN cord-015021-pol2qm74 82 20 which which WDT cord-015021-pol2qm74 82 21 can can MD cord-015021-pol2qm74 82 22 affect affect VB cord-015021-pol2qm74 82 23 blood blood NN cord-015021-pol2qm74 82 24 pressure pressure NN cord-015021-pol2qm74 82 25 . . . cord-015021-pol2qm74 83 1 In in IN cord-015021-pol2qm74 83 2 a a DT cord-015021-pol2qm74 83 3 second second JJ cord-015021-pol2qm74 83 4 study study NN cord-015021-pol2qm74 83 5 , , , cord-015021-pol2qm74 83 6 two two CD cord-015021-pol2qm74 83 7 groups group NNS cord-015021-pol2qm74 83 8 of of IN cord-015021-pol2qm74 83 9 pigs pig NNS cord-015021-pol2qm74 83 10 ( ( -LRB- cord-015021-pol2qm74 83 11 3 3 CD cord-015021-pol2qm74 83 12 / / SYM cord-015021-pol2qm74 83 13 group group NN cord-015021-pol2qm74 83 14 ) ) -RRB- cord-015021-pol2qm74 83 15 were be VBD cord-015021-pol2qm74 83 16 given give VBN cord-015021-pol2qm74 83 17 either either CC cord-015021-pol2qm74 83 18 DXS DXS NNP cord-015021-pol2qm74 83 19 alone alone JJ cord-015021-pol2qm74 83 20 ( ( -LRB- cord-015021-pol2qm74 83 21 2 2 CD cord-015021-pol2qm74 83 22 mg mg NNP cord-015021-pol2qm74 83 23 / / SYM cord-015021-pol2qm74 83 24 kg kg NNP cord-015021-pol2qm74 83 25 ) ) -RRB- cord-015021-pol2qm74 83 26 or or CC cord-015021-pol2qm74 83 27 DXS DXS NNP cord-015021-pol2qm74 83 28 10 10 CD cord-015021-pol2qm74 83 29 minutes minute NNS cord-015021-pol2qm74 83 30 after after IN cord-015021-pol2qm74 83 31 a a DT cord-015021-pol2qm74 83 32 bolus bolus NN cord-015021-pol2qm74 83 33 injection injection NN cord-015021-pol2qm74 83 34 of of IN cord-015021-pol2qm74 83 35 Hoe Hoe NNP cord-015021-pol2qm74 83 36 140 140 CD cord-015021-pol2qm74 83 37 ( ( -LRB- cord-015021-pol2qm74 83 38 30 30 CD cord-015021-pol2qm74 83 39 # # NN cord-015021-pol2qm74 83 40 g g NN cord-015021-pol2qm74 83 41 / / SYM cord-015021-pol2qm74 83 42 kg kg NNP cord-015021-pol2qm74 83 43 ) ) -RRB- cord-015021-pol2qm74 83 44 . . . cord-015021-pol2qm74 84 1 DXS DXS NNP cord-015021-pol2qm74 84 2 alone alone RB cord-015021-pol2qm74 84 3 produced produce VBD cord-015021-pol2qm74 84 4 transient transient JJ cord-015021-pol2qm74 84 5 hypotenmon hypotenmon NN cord-015021-pol2qm74 84 6 . . . cord-015021-pol2qm74 85 1 This this DT cord-015021-pol2qm74 85 2 response response NN cord-015021-pol2qm74 85 3 was be VBD cord-015021-pol2qm74 85 4 completely completely RB cord-015021-pol2qm74 85 5 blocked block VBN cord-015021-pol2qm74 85 6 by by IN cord-015021-pol2qm74 85 7 Hoe Hoe NNP cord-015021-pol2qm74 85 8 140 140 CD cord-015021-pol2qm74 85 9 pretreatment pretreatment NN cord-015021-pol2qm74 85 10 . . . cord-015021-pol2qm74 86 1 Both both DT cord-015021-pol2qm74 86 2 groups group NNS cord-015021-pol2qm74 86 3 had have VBD cord-015021-pol2qm74 86 4 identical identical JJ cord-015021-pol2qm74 86 5 reductions reduction NNS cord-015021-pol2qm74 86 6 in in IN cord-015021-pol2qm74 86 7 kinin kinin NNP cord-015021-pol2qm74 86 8 - - HYPH cord-015021-pol2qm74 86 9 containing contain VBG cord-015021-pol2qm74 86 10 kininogen kininogen NNP cord-015021-pol2qm74 86 11 . . . cord-015021-pol2qm74 87 1 We -PRON- PRP cord-015021-pol2qm74 87 2 conclude conclude VBP cord-015021-pol2qm74 87 3 that that IN cord-015021-pol2qm74 87 4 DXS DXS NNP cord-015021-pol2qm74 87 5 - - HYPH cord-015021-pol2qm74 87 6 induced induce VBN cord-015021-pol2qm74 87 7 hypotension hypotension NN cord-015021-pol2qm74 87 8 is be VBZ cord-015021-pol2qm74 87 9 produced produce VBN cord-015021-pol2qm74 87 10 by by IN cord-015021-pol2qm74 87 11 activation activation NN cord-015021-pol2qm74 87 12 of of IN cord-015021-pol2qm74 87 13 the the DT cord-015021-pol2qm74 87 14 contact contact NN cord-015021-pol2qm74 87 15 system system NN cord-015021-pol2qm74 87 16 which which WDT cord-015021-pol2qm74 87 17 results result VBZ cord-015021-pol2qm74 87 18 in in IN cord-015021-pol2qm74 87 19 the the DT cord-015021-pol2qm74 87 20 production production NN cord-015021-pol2qm74 87 21 of of IN cord-015021-pol2qm74 87 22 bradykinin bradykinin NN cord-015021-pol2qm74 87 23 . . . cord-015021-pol2qm74 88 1 Liberation liberation NN cord-015021-pol2qm74 88 2 of of IN cord-015021-pol2qm74 88 3 bradykinin bradykinin NN cord-015021-pol2qm74 88 4 is be VBZ cord-015021-pol2qm74 88 5 both both DT cord-015021-pol2qm74 88 6 necessary necessary JJ cord-015021-pol2qm74 88 7 and and CC cord-015021-pol2qm74 88 8 sufficient sufficient JJ cord-015021-pol2qm74 88 9 to to TO cord-015021-pol2qm74 88 10 produce produce VB cord-015021-pol2qm74 88 11 all all DT cord-015021-pol2qm74 88 12 of of IN cord-015021-pol2qm74 88 13 the the DT cord-015021-pol2qm74 88 14 hemodynamic hemodynamic JJ cord-015021-pol2qm74 88 15 changes change NNS cord-015021-pol2qm74 88 16 observed observe VBD cord-015021-pol2qm74 88 17 . . . cord-015021-pol2qm74 89 1 Dr. Dr. NNP cord-015021-pol2qm74 89 2 Matthias Matthias NNP cord-015021-pol2qm74 89 3 Siebeck Siebeck NNP cord-015021-pol2qm74 89 4 , , , cord-015021-pol2qm74 89 5 Department Department NNP cord-015021-pol2qm74 89 6 of of IN cord-015021-pol2qm74 89 7 Surgery Surgery NNP cord-015021-pol2qm74 89 8 , , , cord-015021-pol2qm74 89 9 University University NNP cord-015021-pol2qm74 89 10 of of IN cord-015021-pol2qm74 89 11 Munich Munich NNP cord-015021-pol2qm74 89 12 , , , cord-015021-pol2qm74 89 13 Klinikum Klinikum NNP cord-015021-pol2qm74 89 14 lnnenstadt lnnenstadt NN cord-015021-pol2qm74 89 15 , , , cord-015021-pol2qm74 89 16 Nussbaumstrasse Nussbaumstrasse NNP cord-015021-pol2qm74 89 17 20 20 CD cord-015021-pol2qm74 89 18 , , , cord-015021-pol2qm74 89 19 D-80336 d-80336 CD cord-015021-pol2qm74 89 20 Munich Munich NNP cord-015021-pol2qm74 89 21 , , , cord-015021-pol2qm74 89 22 Germany Germany NNP cord-015021-pol2qm74 90 1 In in IN cord-015021-pol2qm74 90 2 experimental experimental JJ cord-015021-pol2qm74 90 3 animals animal NNS cord-015021-pol2qm74 90 4 exposed expose VBN cord-015021-pol2qm74 90 5 to to IN cord-015021-pol2qm74 90 6 i.v i.v NNP cord-015021-pol2qm74 90 7 . . NNP cord-015021-pol2qm74 90 8 injection injection NN cord-015021-pol2qm74 90 9 of of IN cord-015021-pol2qm74 90 10 endotoxin endotoxin NN cord-015021-pol2qm74 90 11 accumulation accumulation NN cord-015021-pol2qm74 90 12 of of IN cord-015021-pol2qm74 90 13 leukocytes leukocyte NNS cord-015021-pol2qm74 90 14 in in IN cord-015021-pol2qm74 90 15 various various JJ cord-015021-pol2qm74 90 16 organs organ NNS cord-015021-pol2qm74 90 17 as as IN cord-015021-pol2qm74 90 18 lungs lung NNS cord-015021-pol2qm74 90 19 and and CC cord-015021-pol2qm74 90 20 the the DT cord-015021-pol2qm74 90 21 liver liver NN cord-015021-pol2qm74 90 22 is be VBZ cord-015021-pol2qm74 90 23 a a DT cord-015021-pol2qm74 90 24 prominent prominent JJ cord-015021-pol2qm74 90 25 feature feature NN cord-015021-pol2qm74 90 26 . . . cord-015021-pol2qm74 91 1 As as IN cord-015021-pol2qm74 91 2 a a DT cord-015021-pol2qm74 91 3 part part NN cord-015021-pol2qm74 91 4 of of IN cord-015021-pol2qm74 91 5 these these DT cord-015021-pol2qm74 91 6 morphological morphological JJ cord-015021-pol2qm74 91 7 changes change NNS cord-015021-pol2qm74 91 8 damages damage NNS cord-015021-pol2qm74 91 9 of of IN cord-015021-pol2qm74 91 10 endothelial endothelial JJ cord-015021-pol2qm74 91 11 ceils ceil NNS cord-015021-pol2qm74 91 12 are be VBP cord-015021-pol2qm74 91 13 regularly regularly RB cord-015021-pol2qm74 91 14 seen see VBN cord-015021-pol2qm74 91 15 . . . cord-015021-pol2qm74 92 1 This this DT cord-015021-pol2qm74 92 2 process process NN cord-015021-pol2qm74 92 3 , , , cord-015021-pol2qm74 92 4 which which WDT cord-015021-pol2qm74 92 5 is be VBZ cord-015021-pol2qm74 92 6 a a DT cord-015021-pol2qm74 92 7 part part NN cord-015021-pol2qm74 92 8 of of IN cord-015021-pol2qm74 92 9 endothelial endothelial JJ cord-015021-pol2qm74 92 10 - - HYPH cord-015021-pol2qm74 92 11 cellular cellular JJ cord-015021-pol2qm74 92 12 interaction interaction NN cord-015021-pol2qm74 92 13 , , , cord-015021-pol2qm74 92 14 leeds leeds NNP cord-015021-pol2qm74 92 15 to to IN cord-015021-pol2qm74 92 16 exposure exposure NN cord-015021-pol2qm74 92 17 of of IN cord-015021-pol2qm74 92 18 the the DT cord-015021-pol2qm74 92 19 sub sub JJ cord-015021-pol2qm74 92 20 - - JJ cord-015021-pol2qm74 92 21 endothelial endothelial JJ cord-015021-pol2qm74 92 22 basement basement NN cord-015021-pol2qm74 92 23 membran membran NN cord-015021-pol2qm74 92 24 . . . cord-015021-pol2qm74 93 1 The the DT cord-015021-pol2qm74 93 2 basement basement NN cord-015021-pol2qm74 93 3 membran membran NN cord-015021-pol2qm74 93 4 is be VBZ cord-015021-pol2qm74 93 5 known know VBN cord-015021-pol2qm74 93 6 f6r f6r PRP cord-015021-pol2qm74 93 7 its -PRON- PRP$ cord-015021-pol2qm74 93 8 capacity capacity NN cord-015021-pol2qm74 93 9 to to TO cord-015021-pol2qm74 93 10 activate activate VB cord-015021-pol2qm74 93 11 the the DT cord-015021-pol2qm74 93 12 contact contact NN cord-015021-pol2qm74 93 13 system system NN cord-015021-pol2qm74 93 14 of of IN cord-015021-pol2qm74 93 15 plasma plasma NN cord-015021-pol2qm74 93 16 . . . cord-015021-pol2qm74 94 1 During during IN cord-015021-pol2qm74 94 2 this this DT cord-015021-pol2qm74 94 3 cascade cascade NN cord-015021-pol2qm74 94 4 activation activation NN cord-015021-pol2qm74 94 5 , , , cord-015021-pol2qm74 94 6 coagulation coagulation NN cord-015021-pol2qm74 94 7 factor factor NN cord-015021-pol2qm74 94 8 XII XII NNP cord-015021-pol2qm74 94 9 is be VBZ cord-015021-pol2qm74 94 10 converted convert VBN cord-015021-pol2qm74 94 11 to to IN cord-015021-pol2qm74 94 12 the the DT cord-015021-pol2qm74 94 13 active active JJ cord-015021-pol2qm74 94 14 factor factor NN cord-015021-pol2qm74 94 15 XII XII NNP cord-015021-pol2qm74 94 16 . . . cord-015021-pol2qm74 95 1 This this DT cord-015021-pol2qm74 95 2 activation activation NN cord-015021-pol2qm74 95 3 might may MD cord-015021-pol2qm74 95 4 produce produce VB cord-015021-pol2qm74 95 5 increased increase VBN cord-015021-pol2qm74 95 6 plasma plasma NN cord-015021-pol2qm74 95 7 kallikrein kallikrein NNP cord-015021-pol2qm74 95 8 activities activity NNS cord-015021-pol2qm74 95 9 and and CC cord-015021-pol2qm74 95 10 thereby thereby RB cord-015021-pol2qm74 95 11 give give VB cord-015021-pol2qm74 95 12 release release NN cord-015021-pol2qm74 95 13 of of IN cord-015021-pol2qm74 95 14 the the DT cord-015021-pol2qm74 95 15 vasoactive vasoactive JJ cord-015021-pol2qm74 95 16 substance substance NN cord-015021-pol2qm74 95 17 bradykinin bradykinin NN cord-015021-pol2qm74 95 18 . . . cord-015021-pol2qm74 96 1 Using use VBG cord-015021-pol2qm74 96 2 a a DT cord-015021-pol2qm74 96 3 porcine porcine JJ cord-015021-pol2qm74 96 4 model model NN cord-015021-pol2qm74 96 5 we -PRON- PRP cord-015021-pol2qm74 96 6 have have VBP cord-015021-pol2qm74 96 7 noticed notice VBN cord-015021-pol2qm74 96 8 that that IN cord-015021-pol2qm74 96 9 endotoxin endotoxin NN cord-015021-pol2qm74 96 10 infusion infusion NN cord-015021-pol2qm74 96 11 ( ( -LRB- cord-015021-pol2qm74 96 12 0,01 0,01 VBZ cord-015021-pol2qm74 96 13 mg mg NNP cord-015021-pol2qm74 96 14 / / SYM cord-015021-pol2qm74 96 15 kg kg NNP cord-015021-pol2qm74 96 16 ) ) -RRB- cord-015021-pol2qm74 96 17 induces induce VBZ cord-015021-pol2qm74 96 18 elevated elevated JJ cord-015021-pol2qm74 96 19 plasma plasma NN cord-015021-pol2qm74 96 20 kailikrein kailikrein NN cord-015021-pol2qm74 96 21 activities activity NNS cord-015021-pol2qm74 96 22 within within IN cord-015021-pol2qm74 96 23 two two CD cord-015021-pol2qm74 96 24 hours hour NNS cord-015021-pol2qm74 96 25 after after IN cord-015021-pol2qm74 96 26 the the DT cord-015021-pol2qm74 96 27 start start NN cord-015021-pol2qm74 96 28 of of IN cord-015021-pol2qm74 96 29 the the DT cord-015021-pol2qm74 96 30 infusion infusion NN cord-015021-pol2qm74 96 31 . . . cord-015021-pol2qm74 97 1 This this DT cord-015021-pol2qm74 97 2 enzyme enzyme NN cord-015021-pol2qm74 97 3 activity activity NN cord-015021-pol2qm74 97 4 remained remain VBD cord-015021-pol2qm74 97 5 increased increase VBN cord-015021-pol2qm74 97 6 during during IN cord-015021-pol2qm74 97 7 the the DT cord-015021-pol2qm74 97 8 next next JJ cord-015021-pol2qm74 97 9 hours hour NNS cord-015021-pol2qm74 97 10 and and CC cord-015021-pol2qm74 97 11 reached reach VBN cord-015021-pol2qm74 97 12 value value NN cord-015021-pol2qm74 97 13 of of IN cord-015021-pol2qm74 97 14 up up IN cord-015021-pol2qm74 97 15 to to TO cord-015021-pol2qm74 97 16 50 50 CD cord-015021-pol2qm74 97 17 U/1 u/1 NN cord-015021-pol2qm74 97 18 . . . cord-015021-pol2qm74 98 1 In in IN cord-015021-pol2qm74 98 2 patients patient NNS cord-015021-pol2qm74 98 3 with with IN cord-015021-pol2qm74 98 4 sepsis sepsis NN cord-015021-pol2qm74 98 5 we -PRON- PRP cord-015021-pol2qm74 98 6 also also RB cord-015021-pol2qm74 98 7 have have VBP cord-015021-pol2qm74 98 8 observed observe VBN cord-015021-pol2qm74 98 9 elevated elevated JJ cord-015021-pol2qm74 98 10 plasma plasma NN cord-015021-pol2qm74 98 11 kallikrein kallikrein NNP cord-015021-pol2qm74 98 12 activities activity NNS cord-015021-pol2qm74 98 13 with with IN cord-015021-pol2qm74 98 14 enzyme enzyme NN cord-015021-pol2qm74 98 15 activities activity NNS cord-015021-pol2qm74 98 16 up up IN cord-015021-pol2qm74 98 17 to to IN cord-015021-pol2qm74 98 18 200 200 CD cord-015021-pol2qm74 98 19 U/1 u/1 NN cord-015021-pol2qm74 98 20 . . . cord-015021-pol2qm74 99 1 In in IN cord-015021-pol2qm74 99 2 order order NN cord-015021-pol2qm74 99 3 to to TO cord-015021-pol2qm74 99 4 further further RB cord-015021-pol2qm74 99 5 elucidate elucidate VB cord-015021-pol2qm74 99 6 the the DT cord-015021-pol2qm74 99 7 significance significance NN cord-015021-pol2qm74 99 8 of of IN cord-015021-pol2qm74 99 9 these these DT cord-015021-pol2qm74 99 10 elevated elevated JJ cord-015021-pol2qm74 99 11 enzyme enzyme NN cord-015021-pol2qm74 99 12 activities activity NNS cord-015021-pol2qm74 99 13 , , , cord-015021-pol2qm74 99 14 we -PRON- PRP cord-015021-pol2qm74 99 15 prepared prepare VBD cord-015021-pol2qm74 99 16 human human JJ cord-015021-pol2qm74 99 17 plasma plasma NN cord-015021-pol2qm74 99 18 kallikrein kallikrein NNP cord-015021-pol2qm74 99 19 and and CC cord-015021-pol2qm74 99 20 injected inject VBD cord-015021-pol2qm74 99 21 it -PRON- PRP cord-015021-pol2qm74 99 22 intravenously intravenously RB cord-015021-pol2qm74 99 23 in in IN cord-015021-pol2qm74 99 24 anaesthetized anaesthetize VBN cord-015021-pol2qm74 99 25 pigs pig NNS cord-015021-pol2qm74 99 26 ( ( -LRB- cord-015021-pol2qm74 99 27 1 1 CD cord-015021-pol2qm74 99 28 ) ) -RRB- cord-015021-pol2qm74 99 29 . . . cord-015021-pol2qm74 100 1 When when WRB cord-015021-pol2qm74 100 2 very very RB cord-015021-pol2qm74 100 3 small small JJ cord-015021-pol2qm74 100 4 plasma plasma NN cord-015021-pol2qm74 100 5 kailikrein kailikrein NN cord-015021-pol2qm74 100 6 activities activity NNS cord-015021-pol2qm74 100 7 ( ( -LRB- cord-015021-pol2qm74 100 8 0,3 0,3 CD cord-015021-pol2qm74 100 9 U U NNP cord-015021-pol2qm74 100 10 / / SYM cord-015021-pol2qm74 100 11 kg kg NN cord-015021-pol2qm74 100 12 bodyweight bodyweight NN cord-015021-pol2qm74 100 13 ) ) -RRB- cord-015021-pol2qm74 100 14 were be VBD cord-015021-pol2qm74 100 15 given give VBN cord-015021-pol2qm74 100 16 intravenously intravenously RB cord-015021-pol2qm74 100 17 a a DT cord-015021-pol2qm74 100 18 50 50 CD cord-015021-pol2qm74 100 19 % % NN cord-015021-pol2qm74 100 20 decrease decrease NN cord-015021-pol2qm74 100 21 in in IN cord-015021-pol2qm74 100 22 arterial arterial JJ cord-015021-pol2qm74 100 23 blood blood NN cord-015021-pol2qm74 100 24 pressure pressure NN cord-015021-pol2qm74 100 25 was be VBD cord-015021-pol2qm74 100 26 seen see VBN cord-015021-pol2qm74 100 27 in in IN cord-015021-pol2qm74 100 28 the the DT cord-015021-pol2qm74 100 29 animals animal NNS cord-015021-pol2qm74 100 30 . . . cord-015021-pol2qm74 101 1 In in IN cord-015021-pol2qm74 101 2 the the DT cord-015021-pol2qm74 101 3 patients patient NNS cord-015021-pol2qm74 101 4 with with IN cord-015021-pol2qm74 101 5 sepsis sepsis NN cord-015021-pol2qm74 101 6 also also RB cord-015021-pol2qm74 101 7 decreases decrease VBZ cord-015021-pol2qm74 101 8 in in IN cord-015021-pol2qm74 101 9 prekallikrein prekallikrein NN cord-015021-pol2qm74 101 10 values value NNS cord-015021-pol2qm74 101 11 and and CC cord-015021-pol2qm74 101 12 functional functional JJ cord-015021-pol2qm74 101 13 plasma plasma NN cord-015021-pol2qm74 101 14 kallikrein kallikrein NNP cord-015021-pol2qm74 101 15 inhibition inhibition NN cord-015021-pol2qm74 101 16 are be VBP cord-015021-pol2qm74 101 17 frequently frequently RB cord-015021-pol2qm74 101 18 seen see VBN cord-015021-pol2qm74 101 19 . . . cord-015021-pol2qm74 102 1 Furthermore furthermore RB cord-015021-pol2qm74 102 2 , , , cord-015021-pol2qm74 102 3 degradation degradation NN cord-015021-pol2qm74 102 4 of of IN cord-015021-pol2qm74 102 5 high high JJ cord-015021-pol2qm74 102 6 molecular molecular JJ cord-015021-pol2qm74 102 7 weight weight NN cord-015021-pol2qm74 102 8 kioinogen kioinogen NNP cord-015021-pol2qm74 102 9 is be VBZ cord-015021-pol2qm74 102 10 found find VBN cord-015021-pol2qm74 102 11 in in IN cord-015021-pol2qm74 102 12 these these DT cord-015021-pol2qm74 102 13 patients patient NNS cord-015021-pol2qm74 102 14 indicating indicate VBG cord-015021-pol2qm74 102 15 formation formation NN cord-015021-pol2qm74 102 16 of of IN cord-015021-pol2qm74 102 17 bradykinin bradykinin NN cord-015021-pol2qm74 102 18 . . . cord-015021-pol2qm74 103 1 These these DT cord-015021-pol2qm74 103 2 experimental experimental JJ cord-015021-pol2qm74 103 3 and and CC cord-015021-pol2qm74 103 4 clinical clinical JJ cord-015021-pol2qm74 103 5 studies study NNS cord-015021-pol2qm74 103 6 underline underline VBP cord-015021-pol2qm74 103 7 that that IN cord-015021-pol2qm74 103 8 contact contact NN cord-015021-pol2qm74 103 9 activation activation NN cord-015021-pol2qm74 103 10 in in IN cord-015021-pol2qm74 103 11 sepsis sepsis NN cord-015021-pol2qm74 103 12 might may MD cord-015021-pol2qm74 103 13 results result VBZ cord-015021-pol2qm74 103 14 in in IN cord-015021-pol2qm74 103 15 the the DT cord-015021-pol2qm74 103 16 release release NN cord-015021-pol2qm74 103 17 of of IN cord-015021-pol2qm74 103 18 very very RB cord-015021-pol2qm74 103 19 powerful powerful JJ cord-015021-pol2qm74 103 20 mediator mediator NN cord-015021-pol2qm74 103 21 substances substance NNS cord-015021-pol2qm74 103 22 which which WDT cord-015021-pol2qm74 103 23 can can MD cord-015021-pol2qm74 103 24 be be VB cord-015021-pol2qm74 103 25 of of IN cord-015021-pol2qm74 103 26 pathophysiological pathophysiological JJ cord-015021-pol2qm74 103 27 importance importance NN cord-015021-pol2qm74 103 28 in in IN cord-015021-pol2qm74 103 29 this this DT cord-015021-pol2qm74 103 30 disease disease NN cord-015021-pol2qm74 103 31 . . . cord-015021-pol2qm74 104 1 A a DT cord-015021-pol2qm74 104 2 number number NN cord-015021-pol2qm74 104 3 of of IN cord-015021-pol2qm74 104 4 pathological pathological JJ cord-015021-pol2qm74 104 5 disorders disorder NNS cord-015021-pol2qm74 104 6 as as IN cord-015021-pol2qm74 104 7 reperfusion reperfusion NN cord-015021-pol2qm74 104 8 injury injury NN cord-015021-pol2qm74 104 9 , , , cord-015021-pol2qm74 104 10 bone bone NN cord-015021-pol2qm74 104 11 marrow marrow NN cord-015021-pol2qm74 104 12 transplantation transplantation NN cord-015021-pol2qm74 104 13 , , , cord-015021-pol2qm74 104 14 polytrauma polytrauma NN cord-015021-pol2qm74 104 15 and and CC cord-015021-pol2qm74 104 16 septic septic JJ cord-015021-pol2qm74 104 17 shock shock NN cord-015021-pol2qm74 104 18 are be VBP cord-015021-pol2qm74 104 19 associated associate VBN cord-015021-pol2qm74 104 20 with with IN cord-015021-pol2qm74 104 21 capillary capillary JJ cord-015021-pol2qm74 104 22 leakage leakage NN cord-015021-pol2qm74 104 23 . . . cord-015021-pol2qm74 105 1 As as IN cord-015021-pol2qm74 105 2 the the DT cord-015021-pol2qm74 105 3 activation activation NN cord-015021-pol2qm74 105 4 of of IN cord-015021-pol2qm74 105 5 the the DT cord-015021-pol2qm74 105 6 complement complement JJ cord-015021-pol2qm74 105 7 system system NN cord-015021-pol2qm74 105 8 and and CC cord-015021-pol2qm74 105 9 the the DT cord-015021-pol2qm74 105 10 contact contact NN cord-015021-pol2qm74 105 11 phase phase NN cord-015021-pol2qm74 105 12 play play VBP cord-015021-pol2qm74 105 13 a a DT cord-015021-pol2qm74 105 14 major major JJ cord-015021-pol2qm74 105 15 role role NN cord-015021-pol2qm74 105 16 in in IN cord-015021-pol2qm74 105 17 these these DT cord-015021-pol2qm74 105 18 diseases disease NNS cord-015021-pol2qm74 105 19 we -PRON- PRP cord-015021-pol2qm74 105 20 investigated investigate VBD cord-015021-pol2qm74 105 21 whether whether IN cord-015021-pol2qm74 105 22 Cl Cl NNP cord-015021-pol2qm74 105 23 - - HYPH cord-015021-pol2qm74 105 24 lnhibitor lnhibitor NNP cord-015021-pol2qm74 105 25 ( ( -LRB- cord-015021-pol2qm74 105 26 C1-INH C1-INH NNP cord-015021-pol2qm74 105 27 ) ) -RRB- cord-015021-pol2qm74 105 28 , , , cord-015021-pol2qm74 105 29 which which WDT cord-015021-pol2qm74 105 30 inactivates inactivate VBZ cord-015021-pol2qm74 105 31 Cl Cl NNP cord-015021-pol2qm74 105 32 - - HYPH cord-015021-pol2qm74 105 33 esterase esterase NN cord-015021-pol2qm74 105 34 , , , cord-015021-pol2qm74 105 35 kallikrein kallikrein NN cord-015021-pol2qm74 105 36 and and CC cord-015021-pol2qm74 105 37 clotting clotting NN cord-015021-pol2qm74 105 38 factors factor NNS cord-015021-pol2qm74 105 39 XII XII NNP cord-015021-pol2qm74 105 40 and and CC cord-015021-pol2qm74 105 41 Xl Xl NNP cord-015021-pol2qm74 105 42 , , , cord-015021-pol2qm74 105 43 could could MD cord-015021-pol2qm74 105 44 abolish abolish VB cord-015021-pol2qm74 105 45 vascular vascular JJ cord-015021-pol2qm74 105 46 leakage leakage NN cord-015021-pol2qm74 105 47 . . . cord-015021-pol2qm74 106 1 A a DT cord-015021-pol2qm74 106 2 capillary capillary JJ cord-015021-pol2qm74 106 3 leakage leakage NN cord-015021-pol2qm74 106 4 was be VBD cord-015021-pol2qm74 106 5 induced induce VBN cord-015021-pol2qm74 106 6 in in IN cord-015021-pol2qm74 106 7 rats rat NNS cord-015021-pol2qm74 106 8 by by IN cord-015021-pol2qm74 106 9 the the DT cord-015021-pol2qm74 106 10 administration administration NN cord-015021-pol2qm74 106 11 of of IN cord-015021-pol2qm74 106 12 interleukin-2 interleukin-2 NNP cord-015021-pol2qm74 106 13 ( ( -LRB- cord-015021-pol2qm74 106 14 5 5 CD cord-015021-pol2qm74 106 15 x x SYM cord-015021-pol2qm74 106 16 106 106 CD cord-015021-pol2qm74 106 17 IU IU NNP cord-015021-pol2qm74 106 18 / / SYM cord-015021-pol2qm74 106 19 kg kg NNP cord-015021-pol2qm74 106 20 ) ) -RRB- cord-015021-pol2qm74 106 21 . . . cord-015021-pol2qm74 107 1 The the DT cord-015021-pol2qm74 107 2 increased increased JJ cord-015021-pol2qm74 107 3 vascular vascular JJ cord-015021-pol2qm74 107 4 permeability permeability NN cord-015021-pol2qm74 107 5 was be VBD cord-015021-pol2qm74 107 6 monitored monitor VBN cord-015021-pol2qm74 107 7 for for IN cord-015021-pol2qm74 107 8 one one CD cord-015021-pol2qm74 107 9 hour hour NN cord-015021-pol2qm74 107 10 as as IN cord-015021-pol2qm74 107 11 the the DT cord-015021-pol2qm74 107 12 extravasation extravasation NN cord-015021-pol2qm74 107 13 of of IN cord-015021-pol2qm74 107 14 FITC FITC NNP cord-015021-pol2qm74 107 15 marked mark VBD cord-015021-pol2qm74 107 16 rat rat NN cord-015021-pol2qm74 107 17 serum serum NN cord-015021-pol2qm74 107 18 albumin albumin NN cord-015021-pol2qm74 107 19 from from IN cord-015021-pol2qm74 107 20 a a DT cord-015021-pol2qm74 107 21 mesenterial mesenterial JJ cord-015021-pol2qm74 107 22 vessel vessel NN cord-015021-pol2qm74 107 23 by by IN cord-015021-pol2qm74 107 24 a a DT cord-015021-pol2qm74 107 25 video video NN cord-015021-pol2qm74 107 26 - - HYPH cord-015021-pol2qm74 107 27 image image NN cord-015021-pol2qm74 107 28 processing processing NN cord-015021-pol2qm74 107 29 system system NN cord-015021-pol2qm74 107 30 . . . cord-015021-pol2qm74 108 1 CI CI NNP cord-015021-pol2qm74 108 2 - - HYPH cord-015021-pol2qm74 108 3 INH INH NNP cord-015021-pol2qm74 109 1 ( ( -LRB- cord-015021-pol2qm74 109 2 Berinert Berinert NNP cord-015021-pol2qm74 109 3 ® ® ADD cord-015021-pol2qm74 109 4 , , , cord-015021-pol2qm74 109 5 Behringwerke Behringwerke NNP cord-015021-pol2qm74 109 6 ) ) -RRB- cord-015021-pol2qm74 109 7 given give VBN cord-015021-pol2qm74 109 8 as as IN cord-015021-pol2qm74 109 9 a a DT cord-015021-pol2qm74 109 10 single single JJ cord-015021-pol2qm74 109 11 i.v i.v NNP cord-015021-pol2qm74 109 12 . . NNP cord-015021-pol2qm74 109 13 bolus bolus NN cord-015021-pol2qm74 109 14 in in IN cord-015021-pol2qm74 109 15 concentrations concentration NNS cord-015021-pol2qm74 109 16 of of IN cord-015021-pol2qm74 109 17 100 100 CD cord-015021-pol2qm74 109 18 , , , cord-015021-pol2qm74 109 19 250 250 CD cord-015021-pol2qm74 109 20 or or CC cord-015021-pol2qm74 109 21 500 500 CD cord-015021-pol2qm74 109 22 U u NN cord-015021-pol2qm74 109 23 / / SYM cord-015021-pol2qm74 109 24 kg kg CC cord-015021-pol2qm74 109 25 dose dose RB cord-015021-pol2qm74 109 26 - - HYPH cord-015021-pol2qm74 109 27 dependently dependently RB cord-015021-pol2qm74 109 28 prevented prevent VBD cord-015021-pol2qm74 109 29 the the DT cord-015021-pol2qm74 109 30 capillary capillary JJ cord-015021-pol2qm74 109 31 leakage leakage NN cord-015021-pol2qm74 109 32 . . . cord-015021-pol2qm74 110 1 Carrageenaninduced carrageenaninduced JJ cord-015021-pol2qm74 110 2 inflammation inflammation NN cord-015021-pol2qm74 110 3 in in IN cord-015021-pol2qm74 110 4 the the DT cord-015021-pol2qm74 110 5 rat rat NN cord-015021-pol2qm74 110 6 leads lead VBZ cord-015021-pol2qm74 110 7 to to IN cord-015021-pol2qm74 110 8 vascutar vascutar NN cord-015021-pol2qm74 110 9 leakage leakage NN cord-015021-pol2qm74 110 10 and and CC cord-015021-pol2qm74 110 11 to to IN cord-015021-pol2qm74 110 12 edematous edematous JJ cord-015021-pol2qm74 110 13 swelling swelling NN cord-015021-pol2qm74 110 14 of of IN cord-015021-pol2qm74 110 15 the the DT cord-015021-pol2qm74 110 16 paw paw NN cord-015021-pol2qm74 110 17 . . . cord-015021-pol2qm74 111 1 CI CI NNP cord-015021-pol2qm74 111 2 - - HYPH cord-015021-pol2qm74 111 3 INH INH NNP cord-015021-pol2qm74 111 4 in in IN cord-015021-pol2qm74 111 5 this this DT cord-015021-pol2qm74 111 6 model model NN cord-015021-pol2qm74 111 7 leads lead VBZ cord-015021-pol2qm74 111 8 to to IN cord-015021-pol2qm74 111 9 a a DT cord-015021-pol2qm74 111 10 dose dose NN cord-015021-pol2qm74 111 11 - - HYPH cord-015021-pol2qm74 111 12 dependent dependent JJ cord-015021-pol2qm74 111 13 decrease decrease NN cord-015021-pol2qm74 111 14 in in IN cord-015021-pol2qm74 111 15 paw paw NN cord-015021-pol2qm74 111 16 edema edema NN cord-015021-pol2qm74 111 17 formation formation NN cord-015021-pol2qm74 111 18 . . . cord-015021-pol2qm74 112 1 Finally finally RB cord-015021-pol2qm74 112 2 , , , cord-015021-pol2qm74 112 3 we -PRON- PRP cord-015021-pol2qm74 112 4 investigated investigate VBD cord-015021-pol2qm74 112 5 the the DT cord-015021-pol2qm74 112 6 effect effect NN cord-015021-pol2qm74 112 7 of of IN cord-015021-pol2qm74 112 8 CI CI NNP cord-015021-pol2qm74 112 9 - - HYPH cord-015021-pol2qm74 112 10 INH INH NNP cord-015021-pol2qm74 112 11 ( ( -LRB- cord-015021-pol2qm74 112 12 infusion infusion NN cord-015021-pol2qm74 112 13 ( ( -LRB- cord-015021-pol2qm74 112 14 100 100 CD cord-015021-pol2qm74 112 15 - - SYM cord-015021-pol2qm74 112 16 125 125 CD cord-015021-pol2qm74 112 17 U U NNP cord-015021-pol2qm74 112 18 / / SYM cord-015021-pol2qm74 112 19 kg kg NN cord-015021-pol2qm74 112 20 x x SYM cord-015021-pol2qm74 112 21 h h NNP cord-015021-pol2qm74 112 22 ) ) -RRB- cord-015021-pol2qm74 112 23 on on IN cord-015021-pol2qm74 112 24 a a DT cord-015021-pol2qm74 112 25 LPS LPS NNP cord-015021-pol2qm74 112 26 - - HYPH cord-015021-pol2qm74 112 27 induced induce VBN cord-015021-pol2qm74 112 28 shock shock NN cord-015021-pol2qm74 112 29 in in IN cord-015021-pol2qm74 112 30 the the DT cord-015021-pol2qm74 112 31 rat rat NN cord-015021-pol2qm74 112 32 by by IN cord-015021-pol2qm74 112 33 combination combination NN cord-015021-pol2qm74 112 34 therapy therapy NN cord-015021-pol2qm74 112 35 with with IN cord-015021-pol2qm74 112 36 the the DT cord-015021-pol2qm74 112 37 antithrombotlc antithrombotlc NN cord-015021-pol2qm74 112 38 agents agent NNS cord-015021-pol2qm74 112 39 antithrombin antithrombin NN cord-015021-pol2qm74 112 40 Ill Ill NNP cord-015021-pol2qm74 112 41 ( ( -LRB- cord-015021-pol2qm74 112 42 Kybernin Kybernin NNP cord-015021-pol2qm74 112 43 ® ® POS cord-015021-pol2qm74 112 44 ) ) -RRB- cord-015021-pol2qm74 112 45 or or CC cord-015021-pol2qm74 112 46 rec rec NNP cord-015021-pol2qm74 112 47 . . . cord-015021-pol2qm74 113 1 Hirudin Hirudin NNP cord-015021-pol2qm74 113 2 ( ( -LRB- cord-015021-pol2qm74 113 3 both both DT cord-015021-pol2qm74 113 4 substances substance NNS cord-015021-pol2qm74 113 5 from from IN cord-015021-pol2qm74 113 6 Behringwerke Behringwerke NNP cord-015021-pol2qm74 113 7 ) ) -RRB- cord-015021-pol2qm74 113 8 . . . cord-015021-pol2qm74 114 1 In in IN cord-015021-pol2qm74 114 2 this this DT cord-015021-pol2qm74 114 3 animal animal NN cord-015021-pol2qm74 114 4 model model NN cord-015021-pol2qm74 114 5 mortality mortality NN cord-015021-pol2qm74 114 6 was be VBD cord-015021-pol2qm74 114 7 90 90 CD cord-015021-pol2qm74 114 8 % % NN cord-015021-pol2qm74 114 9 in in IN cord-015021-pol2qm74 114 10 the the DT cord-015021-pol2qm74 114 11 untreated untreated JJ cord-015021-pol2qm74 114 12 control control NN cord-015021-pol2qm74 114 13 . . . cord-015021-pol2qm74 115 1 Both both DT cord-015021-pol2qm74 115 2 antithrombotic antithrombotic JJ cord-015021-pol2qm74 115 3 agents agent NNS cord-015021-pol2qm74 115 4 decreased decrease VBD cord-015021-pol2qm74 115 5 mortality mortality NN cord-015021-pol2qm74 115 6 rates rate NNS cord-015021-pol2qm74 115 7 by by IN cord-015021-pol2qm74 115 8 inhibiting inhibit VBG cord-015021-pol2qm74 115 9 formation formation NN cord-015021-pol2qm74 115 10 of of IN cord-015021-pol2qm74 115 11 DIC DIC NNP cord-015021-pol2qm74 115 12 ; ; : cord-015021-pol2qm74 115 13 a a DT cord-015021-pol2qm74 115 14 further further JJ cord-015021-pol2qm74 115 15 significant significant JJ cord-015021-pol2qm74 115 16 improvement improvement NN cord-015021-pol2qm74 115 17 of of IN cord-015021-pol2qm74 115 18 survival survival NN cord-015021-pol2qm74 115 19 was be VBD cord-015021-pol2qm74 115 20 achieved achieve VBN cord-015021-pol2qm74 115 21 by by IN cord-015021-pol2qm74 115 22 the the DT cord-015021-pol2qm74 115 23 treatment treatment NN cord-015021-pol2qm74 115 24 with with IN cord-015021-pol2qm74 115 25 CI CI NNP cord-015021-pol2qm74 115 26 - - HYPH cord-015021-pol2qm74 115 27 INH INH NNP cord-015021-pol2qm74 115 28 . . . cord-015021-pol2qm74 116 1 Thus+ Thus+ NNP cord-015021-pol2qm74 117 1 it -PRON- PRP cord-015021-pol2qm74 117 2 could could MD cord-015021-pol2qm74 117 3 be be VB cord-015021-pol2qm74 117 4 concluded conclude VBN cord-015021-pol2qm74 117 5 that that IN cord-015021-pol2qm74 117 6 C1-INH C1-INH NNP cord-015021-pol2qm74 117 7 has have VBZ cord-015021-pol2qm74 117 8 a a DT cord-015021-pol2qm74 117 9 beneficial beneficial JJ cord-015021-pol2qm74 117 10 effect effect NN cord-015021-pol2qm74 117 11 in in IN cord-015021-pol2qm74 117 12 diseases disease NNS cord-015021-pol2qm74 117 13 associated associate VBN cord-015021-pol2qm74 117 14 with with IN cord-015021-pol2qm74 117 15 a a DT cord-015021-pol2qm74 117 16 vascular vascular JJ cord-015021-pol2qm74 117 17 leakage leakage NN cord-015021-pol2qm74 117 18 . . . cord-015021-pol2qm74 118 1 ICLB ICLB NNP cord-015021-pol2qm74 118 2 and and CC cord-015021-pol2qm74 118 3 Laboratory Laboratory NNP cord-015021-pol2qm74 118 4 for for IN cord-015021-pol2qm74 118 5 Experimental Experimental NNP cord-015021-pol2qm74 118 6 and and CC cord-015021-pol2qm74 118 7 Clinical Clinical NNP cord-015021-pol2qm74 118 8 Immunology Immunology NNP cord-015021-pol2qm74 118 9 , , , cord-015021-pol2qm74 118 10 University University NNP cord-015021-pol2qm74 118 11 of of IN cord-015021-pol2qm74 118 12 Amsterdam Amsterdam NNP cord-015021-pol2qm74 118 13 , , , cord-015021-pol2qm74 118 14 The the DT cord-015021-pol2qm74 118 15 Netherlands Netherlands NNP cord-015021-pol2qm74 118 16 ; ; : cord-015021-pol2qm74 118 17 2Thrombosis 2thrombosis CD cord-015021-pol2qm74 118 18 Research Research NNP cord-015021-pol2qm74 118 19 Center Center NNP cord-015021-pol2qm74 118 20 , , , cord-015021-pol2qm74 118 21 Temple Temple NNP cord-015021-pol2qm74 118 22 University University NNP cord-015021-pol2qm74 118 23 , , , cord-015021-pol2qm74 118 24 Penn Penn NNP cord-015021-pol2qm74 118 25 . . NNP cord-015021-pol2qm74 118 26 , , , cord-015021-pol2qm74 118 27 USA USA NNP cord-015021-pol2qm74 118 28 ; ; : cord-015021-pol2qm74 118 29 3Oklahoma 3Oklahoma NNP cord-015021-pol2qm74 118 30 Medical Medical NNP cord-015021-pol2qm74 118 31 Research Research NNP cord-015021-pol2qm74 118 32 Foundation Foundation NNP cord-015021-pol2qm74 118 33 , , , cord-015021-pol2qm74 118 34 . . . cord-015021-pol2qm74 119 1 Ok ok UH cord-015021-pol2qm74 119 2 . . . cord-015021-pol2qm74 120 1 City City NNP cord-015021-pol2qm74 120 2 , , , cord-015021-pol2qm74 120 3 USA USA NNP cord-015021-pol2qm74 120 4 . . . cord-015021-pol2qm74 121 1 To to TO cord-015021-pol2qm74 121 2 evaluate evaluate VB cord-015021-pol2qm74 121 3 the the DT cord-015021-pol2qm74 121 4 contribution contribution NN cord-015021-pol2qm74 121 5 of of IN cord-015021-pol2qm74 121 6 the the DT cord-015021-pol2qm74 121 7 contact contact NN cord-015021-pol2qm74 121 8 system system NN cord-015021-pol2qm74 121 9 to to TO cord-015021-pol2qm74 121 10 activation activation NN cord-015021-pol2qm74 121 11 of of IN cord-015021-pol2qm74 121 12 other other JJ cord-015021-pol2qm74 121 13 mediator mediator NN cord-015021-pol2qm74 121 14 systems system NNS cord-015021-pol2qm74 121 15 in in IN cord-015021-pol2qm74 121 16 an an DT cord-015021-pol2qm74 121 17 experimental experimental JJ cord-015021-pol2qm74 121 18 model model NN cord-015021-pol2qm74 121 19 of of IN cord-015021-pol2qm74 121 20 sepsis sepsis NN cord-015021-pol2qm74 121 21 , , , cord-015021-pol2qm74 121 22 we -PRON- PRP cord-015021-pol2qm74 121 23 investigated investigate VBD cord-015021-pol2qm74 121 24 the the DT cord-015021-pol2qm74 121 25 effect effect NN cord-015021-pol2qm74 121 26 of of IN cord-015021-pol2qm74 121 27 mAb mab NN cord-015021-pol2qm74 121 28 C6B7 C6B7 NNP cord-015021-pol2qm74 121 29 which which WDT cord-015021-pol2qm74 121 30 inhibits inhibit VBZ cord-015021-pol2qm74 121 31 activation activation NN cord-015021-pol2qm74 121 32 of of IN cord-015021-pol2qm74 121 33 factor factor NN cord-015021-pol2qm74 121 34 XlI xli NN cord-015021-pol2qm74 121 35 , , , cord-015021-pol2qm74 121 36 on on IN cord-015021-pol2qm74 121 37 activation activation NN cord-015021-pol2qm74 121 38 of of IN cord-015021-pol2qm74 121 39 complement complement NN cord-015021-pol2qm74 121 40 and and CC cord-015021-pol2qm74 121 41 fibrinolytic fibrinolytic JJ cord-015021-pol2qm74 121 42 cascades cascade NNS cord-015021-pol2qm74 121 43 and and CC cord-015021-pol2qm74 121 44 activation activation NN cord-015021-pol2qm74 121 45 of of IN cord-015021-pol2qm74 121 46 neutrophils neutrophil NNS cord-015021-pol2qm74 121 47 in in IN cord-015021-pol2qm74 121 48 baboons baboon NNS cord-015021-pol2qm74 121 49 suffering suffer VBG cord-015021-pol2qm74 121 50 from from IN cord-015021-pol2qm74 121 51 a a DT cord-015021-pol2qm74 121 52 lethal lethal JJ cord-015021-pol2qm74 121 53 sepsis sepsis NN cord-015021-pol2qm74 121 54 . . . cord-015021-pol2qm74 122 1 Activation activation NN cord-015021-pol2qm74 122 2 of of IN cord-015021-pol2qm74 122 3 the the DT cord-015021-pol2qm74 122 4 complement complement NN cord-015021-pol2qm74 122 5 system system NN cord-015021-pol2qm74 122 6 was be VBD cord-015021-pol2qm74 122 7 assessed assess VBN cord-015021-pol2qm74 122 8 by by IN cord-015021-pol2qm74 122 9 measuring measure VBG cord-015021-pol2qm74 122 10 circulating circulate VBG cord-015021-pol2qm74 122 11 levels level NNS cord-015021-pol2qm74 122 12 of of IN cord-015021-pol2qm74 122 13 C3b c3b NN cord-015021-pol2qm74 122 14 / / SYM cord-015021-pol2qm74 122 15 c c NN cord-015021-pol2qm74 122 16 and and CC cord-015021-pol2qm74 122 17 C4b C4b NNP cord-015021-pol2qm74 122 18 / / SYM cord-015021-pol2qm74 122 19 c c NN cord-015021-pol2qm74 122 20 , , , cord-015021-pol2qm74 122 21 and and CC cord-015021-pol2qm74 122 22 a a DT cord-015021-pol2qm74 122 23 significant significant JJ cord-015021-pol2qm74 122 24 reduction reduction NN cord-015021-pol2qm74 122 25 was be VBD cord-015021-pol2qm74 122 26 observed observe VBN cord-015021-pol2qm74 122 27 in in IN cord-015021-pol2qm74 122 28 5 5 CD cord-015021-pol2qm74 122 29 animals animal NNS cord-015021-pol2qm74 122 30 that that WDT cord-015021-pol2qm74 122 31 had have VBD cord-015021-pol2qm74 122 32 received receive VBN cord-015021-pol2qm74 122 33 a a DT cord-015021-pol2qm74 122 34 lethal lethal JJ cord-015021-pol2qm74 122 35 dose dose NN cord-015021-pol2qm74 122 36 of of IN cord-015021-pol2qm74 122 37 E. E. NNP cord-015021-pol2qm74 122 38 coli coli NNS cord-015021-pol2qm74 122 39 together together RB cord-015021-pol2qm74 122 40 with with IN cord-015021-pol2qm74 122 41 mAb mAb NNP cord-015021-pol2qm74 122 42 C687 C687 NNP cord-015021-pol2qm74 122 43 ( ( -LRB- cord-015021-pol2qm74 122 44 treatment treatment NN cord-015021-pol2qm74 122 45 group group NN cord-015021-pol2qm74 122 46 ) ) -RRB- cord-015021-pol2qm74 122 47 , , , cord-015021-pol2qm74 122 48 compared compare VBN cord-015021-pol2qm74 122 49 to to IN cord-015021-pol2qm74 122 50 4 4 CD cord-015021-pol2qm74 122 51 animals animal NNS cord-015021-pol2qm74 122 52 that that WDT cord-015021-pol2qm74 122 53 had have VBD cord-015021-pol2qm74 122 54 received receive VBN cord-015021-pol2qm74 122 55 a a DT cord-015021-pol2qm74 122 56 lethal lethal JJ cord-015021-pol2qm74 122 57 dose dose NN cord-015021-pol2qm74 122 58 of of IN cord-015021-pol2qm74 122 59 E. E. NNP cord-015021-pol2qm74 122 60 coil coil NN cord-015021-pol2qm74 122 61 only only RB cord-015021-pol2qm74 122 62 ( ( -LRB- cord-015021-pol2qm74 122 63 control control NN cord-015021-pol2qm74 122 64 group group NN cord-015021-pol2qm74 122 65 ) ) -RRB- cord-015021-pol2qm74 122 66 . . . cord-015021-pol2qm74 123 1 Activation activation NN cord-015021-pol2qm74 123 2 of of IN cord-015021-pol2qm74 123 3 the the DT cord-015021-pol2qm74 123 4 fibrinolytic fibrinolytic JJ cord-015021-pol2qm74 123 5 system system NN cord-015021-pol2qm74 123 6 as as IN cord-015021-pol2qm74 123 7 reflected reflect VBN cord-015021-pol2qm74 123 8 by by IN cord-015021-pol2qm74 123 9 circulating circulate VBG cord-015021-pol2qm74 123 10 plasmin-=2antiplasmin plasmin-=2antiplasmin NN cord-015021-pol2qm74 123 11 complexes complex NNS cord-015021-pol2qm74 123 12 and and CC cord-015021-pol2qm74 123 13 tissue tissue NN cord-015021-pol2qm74 123 14 plasminogen plasminogen NN cord-015021-pol2qm74 123 15 activator activator NN cord-015021-pol2qm74 123 16 , , , cord-015021-pol2qm74 123 17 and and CC cord-015021-pol2qm74 123 18 activation activation NN cord-015021-pol2qm74 123 19 of of IN cord-015021-pol2qm74 123 20 neutrophils neutrophil NNS cord-015021-pol2qm74 123 21 , , , cord-015021-pol2qm74 123 22 assessed assess VBN cord-015021-pol2qm74 123 23 by by IN cord-015021-pol2qm74 123 24 measuring measure VBG cord-015021-pol2qm74 123 25 circulating circulate VBG cord-015021-pol2qm74 123 26 elastase-=l elastase-=l NNS cord-015021-pol2qm74 123 27 - - HYPH cord-015021-pol2qm74 123 28 antitrypsin antitrypsin NN cord-015021-pol2qm74 123 29 complexes complex NNS cord-015021-pol2qm74 123 30 , , , cord-015021-pol2qm74 123 31 was be VBD cord-015021-pol2qm74 123 32 also also RB cord-015021-pol2qm74 123 33 significantly significantly RB cord-015021-pol2qm74 123 34 less less JJR cord-015021-pol2qm74 123 35 in in IN cord-015021-pol2qm74 123 36 the the DT cord-015021-pol2qm74 123 37 treatment treatment NN cord-015021-pol2qm74 123 38 group group NN cord-015021-pol2qm74 123 39 . . . cord-015021-pol2qm74 124 1 We -PRON- PRP cord-015021-pol2qm74 124 2 conclude conclude VBP cord-015021-pol2qm74 124 3 that that IN cord-015021-pol2qm74 124 4 activation activation NN cord-015021-pol2qm74 124 5 of of IN cord-015021-pol2qm74 124 6 the the DT cord-015021-pol2qm74 124 7 contact contact NN cord-015021-pol2qm74 124 8 system system NN cord-015021-pol2qm74 124 9 protein protein NN cord-015021-pol2qm74 124 10 factor factor NN cord-015021-pol2qm74 124 11 Xll Xll NNP cord-015021-pol2qm74 124 12 during during IN cord-015021-pol2qm74 124 13 the the DT cord-015021-pol2qm74 124 14 inflammatory inflammatory JJ cord-015021-pol2qm74 124 15 response response NN cord-015021-pol2qm74 124 16 to to IN cord-015021-pol2qm74 124 17 a a DT cord-015021-pol2qm74 124 18 lethal lethal JJ cord-015021-pol2qm74 124 19 dose dose NN cord-015021-pol2qm74 124 20 of of IN cord-015021-pol2qm74 124 21 E. E. NNP cord-015021-pol2qm74 124 22 coil coil NN cord-015021-pol2qm74 124 23 in in IN cord-015021-pol2qm74 124 24 this this DT cord-015021-pol2qm74 124 25 baboon baboon NN cord-015021-pol2qm74 124 26 model model NN cord-015021-pol2qm74 124 27 , , , cord-015021-pol2qm74 124 28 modulates modulate VBZ cord-015021-pol2qm74 124 29 directly directly RB cord-015021-pol2qm74 124 30 or or CC cord-015021-pol2qm74 124 31 indirectly indirectly RB cord-015021-pol2qm74 124 32 activation activation NN cord-015021-pol2qm74 124 33 of of IN cord-015021-pol2qm74 124 34 the the DT cord-015021-pol2qm74 124 35 complement complement NN cord-015021-pol2qm74 124 36 and and CC cord-015021-pol2qm74 124 37 fibrinolytic fibrinolytic JJ cord-015021-pol2qm74 124 38 systems system NNS cord-015021-pol2qm74 124 39 and and CC cord-015021-pol2qm74 124 40 that that IN cord-015021-pol2qm74 124 41 of of IN cord-015021-pol2qm74 124 42 neutrophils neutrophil NNS cord-015021-pol2qm74 124 43 . . . cord-015021-pol2qm74 125 1 In in IN cord-015021-pol2qm74 125 2 a a DT cord-015021-pol2qm74 125 3 prospective prospective JJ cord-015021-pol2qm74 125 4 study study NN cord-015021-pol2qm74 125 5 , , , cord-015021-pol2qm74 125 6 plasma plasma NN cord-015021-pol2qm74 125 7 levels level NNS cord-015021-pol2qm74 125 8 of of IN cord-015021-pol2qm74 125 9 C3a C3a NNP cord-015021-pol2qm74 125 10 , , , cord-015021-pol2qm74 125 11 C3 C3 NNP cord-015021-pol2qm74 125 12 , , , cord-015021-pol2qm74 125 13 and and CC cord-015021-pol2qm74 125 14 C5a C5a NNS cord-015021-pol2qm74 125 15 were be VBD cord-015021-pol2qm74 125 16 measured measure VBN cord-015021-pol2qm74 125 17 in in IN cord-015021-pol2qm74 125 18 30 30 CD cord-015021-pol2qm74 125 19 patients patient NNS cord-015021-pol2qm74 125 20 from from IN cord-015021-pol2qm74 125 21 an an DT cord-015021-pol2qm74 125 22 internal internal JJ cord-015021-pol2qm74 125 23 intensive intensive JJ cord-015021-pol2qm74 125 24 care care NN cord-015021-pol2qm74 125 25 unit unit NN cord-015021-pol2qm74 125 26 . . . cord-015021-pol2qm74 126 1 20 20 CD cord-015021-pol2qm74 126 2 patients patient NNS cord-015021-pol2qm74 126 3 were be VBD cord-015021-pol2qm74 126 4 clinically clinically RB cord-015021-pol2qm74 126 5 septic septic JJ cord-015021-pol2qm74 126 6 defined define VBN cord-015021-pol2qm74 126 7 by by IN cord-015021-pol2qm74 126 8 the the DT cord-015021-pol2qm74 126 9 criteria criterion NNS cord-015021-pol2qm74 126 10 of of IN cord-015021-pol2qm74 126 11 Bone Bone NNP cord-015021-pol2qm74 126 12 et et NNP cord-015021-pol2qm74 126 13 al.(l al.(l NNP cord-015021-pol2qm74 126 14 ) ) -RRB- cord-015021-pol2qm74 126 15 . . . cord-015021-pol2qm74 127 1 The the DT cord-015021-pol2qm74 127 2 remaining remain VBG cord-015021-pol2qm74 127 3 10 10 CD cord-015021-pol2qm74 127 4 patients patient NNS cord-015021-pol2qm74 127 5 were be VBD cord-015021-pol2qm74 127 6 critically critically RB cord-015021-pol2qm74 127 7 ill ill JJ cord-015021-pol2qm74 127 8 but but CC cord-015021-pol2qm74 127 9 did do VBD cord-015021-pol2qm74 127 10 n't not RB cord-015021-pol2qm74 127 11 fulfill fulfill VB cord-015021-pol2qm74 127 12 the the DT cord-015021-pol2qm74 127 13 clinical clinical JJ cord-015021-pol2qm74 127 14 criteria criterion NNS cord-015021-pol2qm74 127 15 of of IN cord-015021-pol2qm74 127 16 sepsis sepsis NN cord-015021-pol2qm74 127 17 . . . cord-015021-pol2qm74 128 1 From from IN cord-015021-pol2qm74 128 2 both both DT cord-015021-pol2qm74 128 3 groups group NNS cord-015021-pol2qm74 128 4 of of IN cord-015021-pol2qm74 128 5 patients patient NNS cord-015021-pol2qm74 128 6 blood blood NN cord-015021-pol2qm74 128 7 samples sample NNS cord-015021-pol2qm74 128 8 were be VBD cord-015021-pol2qm74 128 9 taken take VBN cord-015021-pol2qm74 128 10 over over RP cord-015021-pol2qm74 128 11 a a DT cord-015021-pol2qm74 128 12 l0 l0 NNP cord-015021-pol2qm74 128 13 days day NNS cord-015021-pol2qm74 128 14 period period NN cord-015021-pol2qm74 128 15 . . . cord-015021-pol2qm74 129 1 During during IN cord-015021-pol2qm74 129 2 the the DT cord-015021-pol2qm74 129 3 first first JJ cord-015021-pol2qm74 129 4 3 3 CD cord-015021-pol2qm74 129 5 days day NNS cord-015021-pol2qm74 129 6 blood blood NN cord-015021-pol2qm74 129 7 samples sample NNS cord-015021-pol2qm74 129 8 were be VBD cord-015021-pol2qm74 129 9 drawn draw VBN cord-015021-pol2qm74 129 10 every every DT cord-015021-pol2qm74 129 11 8 8 CD cord-015021-pol2qm74 129 12 h h NN cord-015021-pol2qm74 129 13 , , , cord-015021-pol2qm74 129 14 on on IN cord-015021-pol2qm74 129 15 day day NN cord-015021-pol2qm74 129 16 4 4 CD cord-015021-pol2qm74 129 17 - - SYM cord-015021-pol2qm74 129 18 6 6 CD cord-015021-pol2qm74 129 19 every every DT cord-015021-pol2qm74 129 20 12 12 CD cord-015021-pol2qm74 129 21 h h NN cord-015021-pol2qm74 129 22 and and CC cord-015021-pol2qm74 129 23 the the DT cord-015021-pol2qm74 129 24 last last JJ cord-015021-pol2qm74 129 25 4 4 CD cord-015021-pol2qm74 129 26 days day NNS cord-015021-pol2qm74 129 27 once once RB cord-015021-pol2qm74 129 28 daily daily RB cord-015021-pol2qm74 129 29 . . . cord-015021-pol2qm74 130 1 Mean mean JJ cord-015021-pol2qm74 130 2 plasma plasma NN cord-015021-pol2qm74 130 3 concentrations concentration NNS cord-015021-pol2qm74 130 4 of of IN cord-015021-pol2qm74 130 5 C3a C3a NNPS cord-015021-pol2qm74 130 6 within within IN cord-015021-pol2qm74 130 7 the the DT cord-015021-pol2qm74 130 8 first first JJ cord-015021-pol2qm74 130 9 32 32 CD cord-015021-pol2qm74 130 10 h h NN cord-015021-pol2qm74 130 11 after after IN cord-015021-pol2qm74 130 12 clinical clinical JJ cord-015021-pol2qm74 130 13 onset onset NN cord-015021-pol2qm74 130 14 of of IN cord-015021-pol2qm74 130 15 sepsis sepsis NN cord-015021-pol2qm74 130 16 were be VBD cord-015021-pol2qm74 130 17 1019 1019 CD cord-015021-pol2qm74 130 18 + + SYM cord-015021-pol2qm74 130 19 618 618 CD cord-015021-pol2qm74 130 20 pg pg NN cord-015021-pol2qm74 130 21 / / SYM cord-015021-pol2qm74 130 22 ml ml NNS cord-015021-pol2qm74 130 23 , , , cord-015021-pol2qm74 130 24 whereas whereas IN cord-015021-pol2qm74 130 25 non non JJ cord-015021-pol2qm74 130 26 - - JJ cord-015021-pol2qm74 130 27 septic septic JJ cord-015021-pol2qm74 130 28 - - HYPH cord-015021-pol2qm74 130 29 patients patient NNS cord-015021-pol2qm74 130 30 exhibited exhibit VBD cord-015021-pol2qm74 130 31 mean mean JJ cord-015021-pol2qm74 130 32 values value NNS cord-015021-pol2qm74 130 33 of of IN cord-015021-pol2qm74 130 34 only only RB cord-015021-pol2qm74 130 35 595 595 CD cord-015021-pol2qm74 130 36 + + CC cord-015021-pol2qm74 130 37 _ _ NN cord-015021-pol2qm74 130 38 312 312 CD cord-015021-pol2qm74 130 39 p_g p_g NNP cord-015021-pol2qm74 130 40 / / SYM cord-015021-pol2qm74 130 41 m/. m/. NNP cord-015021-pol2qm74 130 42 C3 C3 NNP cord-015021-pol2qm74 130 43 levels level NNS cord-015021-pol2qm74 130 44 were be VBD cord-015021-pol2qm74 130 45 lower low JJR cord-015021-pol2qm74 130 46 for for IN cord-015021-pol2qm74 130 47 septic septic NN cord-015021-pol2qm74 130 48 - - HYPH cord-015021-pol2qm74 130 49 patients patient NNS cord-015021-pol2qm74 130 50 ( ( -LRB- cord-015021-pol2qm74 130 51 840 840 CD cord-015021-pol2qm74 130 52 + + SYM cord-015021-pol2qm74 130 53 480 480 CD cord-015021-pol2qm74 130 54 lag lag NN cord-015021-pol2qm74 130 55 / / SYM cord-015021-pol2qm74 130 56 ml ml NN cord-015021-pol2qm74 130 57 ) ) -RRB- cord-015021-pol2qm74 130 58 than than IN cord-015021-pol2qm74 130 59 for for IN cord-015021-pol2qm74 130 60 non non JJ cord-015021-pol2qm74 130 61 - - JJ cord-015021-pol2qm74 130 62 septic septic JJ cord-015021-pol2qm74 130 63 - - HYPH cord-015021-pol2qm74 130 64 patients patient NNS cord-015021-pol2qm74 130 65 ( ( -LRB- cord-015021-pol2qm74 130 66 1340 1340 CD cord-015021-pol2qm74 130 67 _ _ NN cord-015021-pol2qm74 130 68 + + SYM cord-015021-pol2qm74 130 69 770 770 CD cord-015021-pol2qm74 130 70 lag lag NN cord-015021-pol2qm74 130 71 / / SYM cord-015021-pol2qm74 130 72 ml ml NN cord-015021-pol2qm74 130 73 ) ) -RRB- cord-015021-pol2qm74 130 74 . . . cord-015021-pol2qm74 131 1 The the DT cord-015021-pol2qm74 131 2 most most RBS cord-015021-pol2qm74 131 3 profound profound JJ cord-015021-pol2qm74 131 4 difference difference NN cord-015021-pol2qm74 131 5 between between IN cord-015021-pol2qm74 131 6 both both DT cord-015021-pol2qm74 131 7 groups group NNS cord-015021-pol2qm74 131 8 was be VBD cord-015021-pol2qm74 131 9 found find VBN cord-015021-pol2qm74 131 10 , , , cord-015021-pol2qm74 131 11 when when WRB cord-015021-pol2qm74 131 12 the the DT cord-015021-pol2qm74 131 13 C3a C3a NNP cord-015021-pol2qm74 131 14 / / SYM cord-015021-pol2qm74 131 15 C3 c3 NN cord-015021-pol2qm74 131 16 ratio ratio NN cord-015021-pol2qm74 131 17 was be VBD cord-015021-pol2qm74 131 18 compared compare VBN cord-015021-pol2qm74 131 19 ( ( -LRB- cord-015021-pol2qm74 131 20 1.84 1.84 CD cord-015021-pol2qm74 131 21 + + SYM cord-015021-pol2qm74 131 22 2.28 2.28 CD cord-015021-pol2qm74 131 23 for for IN cord-015021-pol2qm74 131 24 septic septic NN cord-015021-pol2qm74 131 25 - - HYPH cord-015021-pol2qm74 131 26 patients patient NNS cord-015021-pol2qm74 131 27 and and CC cord-015021-pol2qm74 132 1 0.4 0.4 CD cord-015021-pol2qm74 132 2 _ _ NN cord-015021-pol2qm74 132 3 + + CC cord-015021-pol2qm74 133 1 _ _ NNP cord-015021-pol2qm74 133 2 0.18 0.18 CD cord-015021-pol2qm74 133 3 for for IN cord-015021-pol2qm74 133 4 the the DT cord-015021-pol2qm74 133 5 control control NN cord-015021-pol2qm74 133 6 group group NN cord-015021-pol2qm74 133 7 ) ) -RRB- cord-015021-pol2qm74 133 8 . . . cord-015021-pol2qm74 134 1 No no DT cord-015021-pol2qm74 134 2 significant significant JJ cord-015021-pol2qm74 134 3 differences difference NNS cord-015021-pol2qm74 134 4 between between IN cord-015021-pol2qm74 134 5 both both DT cord-015021-pol2qm74 134 6 patient patient JJ cord-015021-pol2qm74 134 7 groups group NNS cord-015021-pol2qm74 134 8 were be VBD cord-015021-pol2qm74 134 9 observed observe VBN cord-015021-pol2qm74 134 10 in in IN cord-015021-pol2qm74 134 11 C5a C5a NNS cord-015021-pol2qm74 134 12 plasma plasma NN cord-015021-pol2qm74 134 13 levels level NNS cord-015021-pol2qm74 134 14 ( ( -LRB- cord-015021-pol2qm74 134 15 5.9 5.9 CD cord-015021-pol2qm74 134 16 + + SYM cord-015021-pol2qm74 134 17 2.1 2.1 CD cord-015021-pol2qm74 134 18 ng ng NN cord-015021-pol2qm74 134 19 / / SYM cord-015021-pol2qm74 134 20 ml ml NN cord-015021-pol2qm74 134 21 in in IN cord-015021-pol2qm74 134 22 septic septic JJ cord-015021-pol2qm74 134 23 - - HYPH cord-015021-pol2qm74 134 24 patients patient NNS cord-015021-pol2qm74 134 25 vs. vs. IN cord-015021-pol2qm74 135 1 5.6 5.6 CD cord-015021-pol2qm74 135 2 _ _ NN cord-015021-pol2qm74 135 3 + + CC cord-015021-pol2qm74 136 1 1.5 1.5 CD cord-015021-pol2qm74 136 2 ng ng NN cord-015021-pol2qm74 136 3 / / SYM cord-015021-pol2qm74 136 4 ml ml NN cord-015021-pol2qm74 136 5 in in IN cord-015021-pol2qm74 136 6 control control NN cord-015021-pol2qm74 136 7 patients patient NNS cord-015021-pol2qm74 136 8 ) ) -RRB- cord-015021-pol2qm74 136 9 . . . cord-015021-pol2qm74 137 1 In in IN cord-015021-pol2qm74 137 2 13 13 CD cord-015021-pol2qm74 137 3 of of IN cord-015021-pol2qm74 137 4 20 20 CD cord-015021-pol2qm74 137 5 cases case NNS cord-015021-pol2qm74 137 6 of of IN cord-015021-pol2qm74 137 7 clinically clinically RB cord-015021-pol2qm74 137 8 defined define VBN cord-015021-pol2qm74 137 9 sepsis sepsis NN cord-015021-pol2qm74 137 10 causative causative JJ cord-015021-pol2qm74 137 11 organisms organism NNS cord-015021-pol2qm74 137 12 like like IN cord-015021-pol2qm74 137 13 bacteria bacteria NNS cord-015021-pol2qm74 137 14 , , , cord-015021-pol2qm74 137 15 protozoa protozoan NNS cord-015021-pol2qm74 137 16 or or CC cord-015021-pol2qm74 137 17 fungi fungus NNS cord-015021-pol2qm74 137 18 could could MD cord-015021-pol2qm74 137 19 be be VB cord-015021-pol2qm74 137 20 cultured culture VBN cord-015021-pol2qm74 137 21 from from IN cord-015021-pol2qm74 137 22 blood blood NN cord-015021-pol2qm74 137 23 , , , cord-015021-pol2qm74 137 24 bronchoalveolar bronchoalveolar NNP cord-015021-pol2qm74 137 25 lavages lavage NNS cord-015021-pol2qm74 137 26 and/or and/or CC cord-015021-pol2qm74 137 27 section section NN cord-015021-pol2qm74 137 28 materials material NNS cord-015021-pol2qm74 137 29 . . . cord-015021-pol2qm74 138 1 Application application NN cord-015021-pol2qm74 138 2 of of IN cord-015021-pol2qm74 138 3 the the DT cord-015021-pol2qm74 138 4 complement complement NN cord-015021-pol2qm74 138 5 parameters parameter NNS cord-015021-pol2qm74 138 6 to to IN cord-015021-pol2qm74 138 7 survivors survivor NNS cord-015021-pol2qm74 138 8 ( ( -LRB- cord-015021-pol2qm74 138 9 n=9 n=9 NN cord-015021-pol2qm74 138 10 ) ) -RRB- cord-015021-pol2qm74 138 11 and and CC cord-015021-pol2qm74 138 12 non non NNS cord-015021-pol2qm74 138 13 - - NNS cord-015021-pol2qm74 138 14 survivors survivor NNS cord-015021-pol2qm74 138 15 ( ( -LRB- cord-015021-pol2qm74 138 16 n n NN cord-015021-pol2qm74 138 17 = = SYM cord-015021-pol2qm74 138 18 l l NN cord-015021-pol2qm74 138 19 1 1 CD cord-015021-pol2qm74 138 20 ) ) -RRB- cord-015021-pol2qm74 138 21 within within IN cord-015021-pol2qm74 138 22 the the DT cord-015021-pol2qm74 138 23 septic septic JJ cord-015021-pol2qm74 138 24 - - HYPH cord-015021-pol2qm74 138 25 group group NN cord-015021-pol2qm74 138 26 revealed reveal VBD cord-015021-pol2qm74 138 27 , , , cord-015021-pol2qm74 138 28 that that IN cord-015021-pol2qm74 138 29 the the DT cord-015021-pol2qm74 138 30 C3a C3a NNP cord-015021-pol2qm74 138 31 / / SYM cord-015021-pol2qm74 138 32 C3 c3 NN cord-015021-pol2qm74 138 33 ratio ratio NN cord-015021-pol2qm74 138 34 could could MD cord-015021-pol2qm74 138 35 also also RB cord-015021-pol2qm74 138 36 be be VB cord-015021-pol2qm74 138 37 used use VBN cord-015021-pol2qm74 138 38 as as IN cord-015021-pol2qm74 138 39 a a DT cord-015021-pol2qm74 138 40 prognostic prognostic JJ cord-015021-pol2qm74 138 41 parameter parameter NN cord-015021-pol2qm74 138 42 for for IN cord-015021-pol2qm74 138 43 clinical clinical JJ cord-015021-pol2qm74 138 44 outcome outcome NN cord-015021-pol2qm74 138 45 . . . cord-015021-pol2qm74 139 1 The the DT cord-015021-pol2qm74 139 2 possibility possibility NN cord-015021-pol2qm74 139 3 of of IN cord-015021-pol2qm74 139 4 rapid rapid JJ cord-015021-pol2qm74 139 5 and and CC cord-015021-pol2qm74 139 6 easy easy JJ cord-015021-pol2qm74 139 7 measurement measurement NN cord-015021-pol2qm74 139 8 of of IN cord-015021-pol2qm74 139 9 C3a C3a NNP cord-015021-pol2qm74 139 10 and and CC cord-015021-pol2qm74 139 11 C3 C3 NNP cord-015021-pol2qm74 139 12 in in IN cord-015021-pol2qm74 139 13 only only RB cord-015021-pol2qm74 139 14 20 20 CD cord-015021-pol2qm74 139 15 - - SYM cord-015021-pol2qm74 139 16 25 25 CD cord-015021-pol2qm74 139 17 minutes minute NNS cord-015021-pol2qm74 139 18 ( ( -LRB- cord-015021-pol2qm74 139 19 2 2 CD cord-015021-pol2qm74 139 20 ) ) -RRB- cord-015021-pol2qm74 139 21 and and CC cord-015021-pol2qm74 139 22 the the DT cord-015021-pol2qm74 139 23 significant significant JJ cord-015021-pol2qm74 139 24 difference difference NN cord-015021-pol2qm74 139 25 of of IN cord-015021-pol2qm74 139 26 the the DT cord-015021-pol2qm74 139 27 C3aJC3 C3aJC3 NNP cord-015021-pol2qm74 139 28 ratio ratio NN cord-015021-pol2qm74 139 29 between between IN cord-015021-pol2qm74 139 30 the the DT cord-015021-pol2qm74 139 31 septic septic JJ cord-015021-pol2qm74 139 32 and and CC cord-015021-pol2qm74 139 33 non non JJ cord-015021-pol2qm74 139 34 - - JJ cord-015021-pol2qm74 139 35 septic septic JJ cord-015021-pol2qm74 139 36 group group NN cord-015021-pol2qm74 139 37 renders render VBZ cord-015021-pol2qm74 139 38 this this DT cord-015021-pol2qm74 139 39 parameter parameter NN cord-015021-pol2qm74 139 40 a a DT cord-015021-pol2qm74 139 41 good good JJ cord-015021-pol2qm74 139 42 candidate candidate NN cord-015021-pol2qm74 139 43 for for IN cord-015021-pol2qm74 139 44 early early JJ cord-015021-pol2qm74 139 45 diagnosis diagnosis NN cord-015021-pol2qm74 139 46 of of IN cord-015021-pol2qm74 139 47 sepsis sepsis NN cord-015021-pol2qm74 139 48 in in IN cord-015021-pol2qm74 139 49 the the DT cord-015021-pol2qm74 139 50 intensive intensive JJ cord-015021-pol2qm74 139 51 care care NN cord-015021-pol2qm74 139 52 unit unit NN cord-015021-pol2qm74 139 53 . . . cord-015021-pol2qm74 140 1 Hirudin Hirudin NNP cord-015021-pol2qm74 140 2 , , , cord-015021-pol2qm74 140 3 a a DT cord-015021-pol2qm74 140 4 single single JJ cord-015021-pol2qm74 140 5 polypeptide polypeptide NN cord-015021-pol2qm74 140 6 chain chain NN cord-015021-pol2qm74 140 7 composed compose VBN cord-015021-pol2qm74 140 8 of of IN cord-015021-pol2qm74 140 9 65 65 CD cord-015021-pol2qm74 140 10 amino amino JJ cord-015021-pol2qm74 140 11 acids acid NNS cord-015021-pol2qm74 140 12 with with IN cord-015021-pol2qm74 140 13 6 6 CD cord-015021-pol2qm74 140 14 cysteine cysteine NN cord-015021-pol2qm74 140 15 residues residue NNS cord-015021-pol2qm74 140 16 ( ( -LRB- cord-015021-pol2qm74 140 17 MR MR NNP cord-015021-pol2qm74 140 18 7000 7000 CD cord-015021-pol2qm74 140 19 daitons daiton NNS cord-015021-pol2qm74 140 20 ) ) -RRB- cord-015021-pol2qm74 140 21 , , , cord-015021-pol2qm74 140 22 is be VBZ cord-015021-pol2qm74 140 23 the the DT cord-015021-pol2qm74 140 24 most most RBS cord-015021-pol2qm74 140 25 potent potent JJ cord-015021-pol2qm74 140 26 and and CC cord-015021-pol2qm74 140 27 specific specific JJ cord-015021-pol2qm74 140 28 thrombin thrombin JJ cord-015021-pol2qm74 140 29 inhibitor inhibitor NN cord-015021-pol2qm74 140 30 , , , cord-015021-pol2qm74 140 31 which which WDT cord-015021-pol2qm74 140 32 is be VBZ cord-015021-pol2qm74 140 33 now now RB cord-015021-pol2qm74 140 34 available available JJ cord-015021-pol2qm74 140 35 as as IN cord-015021-pol2qm74 140 36 a a DT cord-015021-pol2qm74 140 37 genetically genetically RB cord-015021-pol2qm74 140 38 engineered engineer VBN cord-015021-pol2qm74 140 39 product product NN cord-015021-pol2qm74 140 40 ( ( -LRB- cord-015021-pol2qm74 140 41 rec rec NNP cord-015021-pol2qm74 140 42 . . . cord-015021-pol2qm74 141 1 Hirudin Hirudin NNP cord-015021-pol2qm74 141 2 -HBW -HBW VBD cord-015021-pol2qm74 141 3 023 023 CD cord-015021-pol2qm74 141 4 , , , cord-015021-pol2qm74 141 5 Behringwerke Behringwerke NNP cord-015021-pol2qm74 141 6 ; ; : cord-015021-pol2qm74 141 7 Marburg Marburg NNP cord-015021-pol2qm74 141 8 ) ) -RRB- cord-015021-pol2qm74 141 9 . . . cord-015021-pol2qm74 142 1 The the DT cord-015021-pol2qm74 142 2 aim aim NN cord-015021-pol2qm74 142 3 of of IN cord-015021-pol2qm74 142 4 our -PRON- PRP$ cord-015021-pol2qm74 142 5 study study NN cord-015021-pol2qm74 142 6 was be VBD cord-015021-pol2qm74 142 7 to to TO cord-015021-pol2qm74 142 8 establish establish VB cord-015021-pol2qm74 142 9 a a DT cord-015021-pol2qm74 142 10 rabbit rabbit NN cord-015021-pol2qm74 142 11 model model NN cord-015021-pol2qm74 142 12 of of IN cord-015021-pol2qm74 142 13 tissue tissue NN cord-015021-pol2qm74 142 14 factor factor NN cord-015021-pol2qm74 142 15 ( ( -LRB- cord-015021-pol2qm74 142 16 TF TF NNP cord-015021-pol2qm74 142 17 ) ) -RRB- cord-015021-pol2qm74 142 18 induced induce VBN cord-015021-pol2qm74 142 19 activation activation NN cord-015021-pol2qm74 142 20 of of IN cord-015021-pol2qm74 142 21 the the DT cord-015021-pol2qm74 142 22 extrinsic extrinsic JJ cord-015021-pol2qm74 142 23 pathway pathway NN cord-015021-pol2qm74 142 24 of of IN cord-015021-pol2qm74 142 25 coagulation coagulation NN cord-015021-pol2qm74 142 26 and and CC cord-015021-pol2qm74 142 27 to to TO cord-015021-pol2qm74 142 28 evaluate evaluate VB cord-015021-pol2qm74 142 29 the the DT cord-015021-pol2qm74 142 30 therapeutic therapeutic JJ cord-015021-pol2qm74 142 31 efficacy efficacy NN cord-015021-pol2qm74 142 32 of of IN cord-015021-pol2qm74 142 33 rec rec NNP cord-015021-pol2qm74 142 34 . . . cord-015021-pol2qm74 143 1 Hirudin Hirudin NNP cord-015021-pol2qm74 143 2 . . . cord-015021-pol2qm74 144 1 Coagulation coagulation NN cord-015021-pol2qm74 144 2 was be VBD cord-015021-pol2qm74 144 3 induced induce VBN cord-015021-pol2qm74 144 4 in in IN cord-015021-pol2qm74 144 5 female female JJ cord-015021-pol2qm74 144 6 NZW NZW NNP cord-015021-pol2qm74 144 7 rabbits rabbit NNS cord-015021-pol2qm74 144 8 by by IN cord-015021-pol2qm74 144 9 infusion infusion NN cord-015021-pol2qm74 144 10 of of IN cord-015021-pol2qm74 144 11 0.5 0.5 CD cord-015021-pol2qm74 144 12 p.g p.g NNP cord-015021-pol2qm74 144 13 / / SYM cord-015021-pol2qm74 144 14 kgxh kgxh FW cord-015021-pol2qm74 144 15 thromboplastin thromboplastin NNP cord-015021-pol2qm74 144 16 for for IN cord-015021-pol2qm74 144 17 7 7 CD cord-015021-pol2qm74 144 18 hours hour NNS cord-015021-pol2qm74 144 19 . . . cord-015021-pol2qm74 145 1 Development development NN cord-015021-pol2qm74 145 2 of of IN cord-015021-pol2qm74 145 3 disseminated disseminate VBN cord-015021-pol2qm74 145 4 clotting clotting NN cord-015021-pol2qm74 145 5 was be VBD cord-015021-pol2qm74 145 6 manifested manifest VBN cord-015021-pol2qm74 145 7 by by IN cord-015021-pol2qm74 145 8 a a DT cord-015021-pol2qm74 145 9 decrease decrease NN cord-015021-pol2qm74 145 10 of of IN cord-015021-pol2qm74 145 11 fibrinogen fibrinogen NN cord-015021-pol2qm74 145 12 and and CC cord-015021-pol2qm74 145 13 platelets platelet NNS cord-015021-pol2qm74 145 14 to to IN cord-015021-pol2qm74 145 15 27.0 27.0 CD cord-015021-pol2qm74 145 16 % % NN cord-015021-pol2qm74 145 17 and and CC cord-015021-pol2qm74 145 18 33,0 33,0 CD cord-015021-pol2qm74 145 19 % % NN cord-015021-pol2qm74 145 20 respectively respectively RB cord-015021-pol2qm74 145 21 , , , cord-015021-pol2qm74 145 22 and and CC cord-015021-pol2qm74 145 23 by by IN cord-015021-pol2qm74 145 24 an an DT cord-015021-pol2qm74 145 25 increase increase NN cord-015021-pol2qm74 145 26 of of IN cord-015021-pol2qm74 145 27 fibrin fibrin NN cord-015021-pol2qm74 145 28 monomers monomer NNS cord-015021-pol2qm74 145 29 from from IN cord-015021-pol2qm74 145 30 13.2 13.2 CD cord-015021-pol2qm74 145 31 to to IN cord-015021-pol2qm74 145 32 > > XX cord-015021-pol2qm74 145 33 85.0 85.0 CD cord-015021-pol2qm74 145 34 ~tg ~tg NNS cord-015021-pol2qm74 145 35 / / SYM cord-015021-pol2qm74 145 36 ml ml NN cord-015021-pol2qm74 145 37 . . . cord-015021-pol2qm74 146 1 We -PRON- PRP cord-015021-pol2qm74 146 2 administered administer VBD cord-015021-pol2qm74 146 3 rec rec NNP cord-015021-pol2qm74 146 4 . . . cord-015021-pol2qm74 147 1 Hirudin hirudin RB cord-015021-pol2qm74 147 2 to to IN cord-015021-pol2qm74 147 3 rabbits rabbit NNS cord-015021-pol2qm74 147 4 in in IN cord-015021-pol2qm74 147 5 3 3 CD cord-015021-pol2qm74 147 6 different different JJ cord-015021-pol2qm74 147 7 concentrations concentration NNS cord-015021-pol2qm74 147 8 ( ( -LRB- cord-015021-pol2qm74 147 9 0.5 0.5 CD cord-015021-pol2qm74 147 10 , , , cord-015021-pol2qm74 147 11 1.0 1.0 CD cord-015021-pol2qm74 147 12 and and CC cord-015021-pol2qm74 147 13 2.0 2.0 CD cord-015021-pol2qm74 147 14 mg mg NNP cord-015021-pol2qm74 147 15 / / SYM cord-015021-pol2qm74 147 16 kg kg NNP cord-015021-pol2qm74 147 17 ) ) -RRB- cord-015021-pol2qm74 147 18 ; ; : cord-015021-pol2qm74 147 19 treatment treatment NN cord-015021-pol2qm74 147 20 started start VBD cord-015021-pol2qm74 147 21 simultaneously simultaneously RB cord-015021-pol2qm74 147 22 with with IN cord-015021-pol2qm74 147 23 the the DT cord-015021-pol2qm74 147 24 infusion infusion NN cord-015021-pol2qm74 147 25 as as IN cord-015021-pol2qm74 147 26 an an DT cord-015021-pol2qm74 147 27 i.v i.v NNP cord-015021-pol2qm74 147 28 . . NNP cord-015021-pol2qm74 147 29 bolus bolus NNP cord-015021-pol2qm74 147 30 . . . cord-015021-pol2qm74 148 1 Rec Rec NNP cord-015021-pol2qm74 148 2 . . . cord-015021-pol2qm74 149 1 Hirudin Hirudin NNP cord-015021-pol2qm74 149 2 significantly significantly RB cord-015021-pol2qm74 149 3 prevented prevent VBD cord-015021-pol2qm74 149 4 the the DT cord-015021-pol2qm74 149 5 decrease decrease NN cord-015021-pol2qm74 149 6 of of IN cord-015021-pol2qm74 149 7 fibrinogen fibrinogen NN cord-015021-pol2qm74 149 8 , , , cord-015021-pol2qm74 149 9 platelets platelet NNS cord-015021-pol2qm74 149 10 and and CC cord-015021-pol2qm74 149 11 the the DT cord-015021-pol2qm74 149 12 increase increase NN cord-015021-pol2qm74 149 13 of of IN cord-015021-pol2qm74 149 14 fibrin fibrin NN cord-015021-pol2qm74 149 15 monomers monomer NNS cord-015021-pol2qm74 149 16 . . . cord-015021-pol2qm74 150 1 This this DT cord-015021-pol2qm74 150 2 effect effect NN cord-015021-pol2qm74 150 3 was be VBD cord-015021-pol2qm74 150 4 dose dose JJ cord-015021-pol2qm74 150 5 dependent dependent JJ cord-015021-pol2qm74 150 6 and and CC cord-015021-pol2qm74 150 7 long long RB cord-015021-pol2qm74 150 8 lasting lasting JJ cord-015021-pol2qm74 150 9 , , , cord-015021-pol2qm74 150 10 even even RB cord-015021-pol2qm74 150 11 7 7 CD cord-015021-pol2qm74 150 12 hours hour NNS cord-015021-pol2qm74 150 13 after after IN cord-015021-pol2qm74 150 14 the the DT cord-015021-pol2qm74 150 15 administration administration NN cord-015021-pol2qm74 150 16 of of IN cord-015021-pol2qm74 150 17 rec rec NNP cord-015021-pol2qm74 150 18 . . . cord-015021-pol2qm74 151 1 Hirudin hirudin RB cord-015021-pol2qm74 151 2 , , , cord-015021-pol2qm74 151 3 clotting clotting NN cord-015021-pol2qm74 151 4 was be VBD cord-015021-pol2qm74 151 5 still still RB cord-015021-pol2qm74 151 6 significantly significantly RB cord-015021-pol2qm74 151 7 reduced reduce VBN cord-015021-pol2qm74 151 8 . . . cord-015021-pol2qm74 152 1 As as IN cord-015021-pol2qm74 152 2 could could MD cord-015021-pol2qm74 152 3 be be VB cord-015021-pol2qm74 152 4 drawn draw VBN cord-015021-pol2qm74 152 5 from from IN cord-015021-pol2qm74 152 6 the the DT cord-015021-pol2qm74 152 7 plasma plasma NN cord-015021-pol2qm74 152 8 levels level NNS cord-015021-pol2qm74 152 9 , , , cord-015021-pol2qm74 152 10 rec rec NNP cord-015021-pol2qm74 152 11 . . . cord-015021-pol2qm74 153 1 Hirudin Hirudin NNP cord-015021-pol2qm74 153 2 had have VBD cord-015021-pol2qm74 153 3 been be VBN cord-015021-pol2qm74 153 4 cleared clear VBN cord-015021-pol2qm74 153 5 from from IN cord-015021-pol2qm74 153 6 plasma plasma NN cord-015021-pol2qm74 153 7 at at IN cord-015021-pol2qm74 153 8 this this DT cord-015021-pol2qm74 153 9 time time NN cord-015021-pol2qm74 153 10 . . . cord-015021-pol2qm74 154 1 In in IN cord-015021-pol2qm74 154 2 a a DT cord-015021-pol2qm74 154 3 post post JJ cord-015021-pol2qm74 154 4 - - JJ cord-015021-pol2qm74 154 5 treatment treatment JJ cord-015021-pol2qm74 154 6 study study NN cord-015021-pol2qm74 154 7 we -PRON- PRP cord-015021-pol2qm74 154 8 administered administer VBD cord-015021-pol2qm74 154 9 rec rec NNP cord-015021-pol2qm74 154 10 . . . cord-015021-pol2qm74 155 1 Hirudin Hirudin NNP cord-015021-pol2qm74 155 2 ( ( -LRB- cord-015021-pol2qm74 155 3 0.5 0.5 CD cord-015021-pol2qm74 155 4 , , , cord-015021-pol2qm74 155 5 1.0 1.0 CD cord-015021-pol2qm74 155 6 and and CC cord-015021-pol2qm74 155 7 2.0 2.0 CD cord-015021-pol2qm74 155 8 mg mg NNP cord-015021-pol2qm74 155 9 / / SYM cord-015021-pol2qm74 155 10 kg kg NNP cord-015021-pol2qm74 155 11 i.v i.v NNP cord-015021-pol2qm74 155 12 . . . cord-015021-pol2qm74 155 13 bolus bolus NNP cord-015021-pol2qm74 155 14 ) ) -RRB- cord-015021-pol2qm74 155 15 as as RB cord-015021-pol2qm74 155 16 late late JJ cord-015021-pol2qm74 155 17 as as IN cord-015021-pol2qm74 155 18 2 2 CD cord-015021-pol2qm74 155 19 hours hour NNS cord-015021-pol2qm74 155 20 after after IN cord-015021-pol2qm74 155 21 the the DT cord-015021-pol2qm74 155 22 start start NN cord-015021-pol2qm74 155 23 of of IN cord-015021-pol2qm74 155 24 TF TF NNP cord-015021-pol2qm74 155 25 infusion infusion NN cord-015021-pol2qm74 155 26 . . . cord-015021-pol2qm74 156 1 At at IN cord-015021-pol2qm74 156 2 this this DT cord-015021-pol2qm74 156 3 time time NN cord-015021-pol2qm74 156 4 there there EX cord-015021-pol2qm74 156 5 was be VBD cord-015021-pol2qm74 156 6 already already RB cord-015021-pol2qm74 156 7 a a DT cord-015021-pol2qm74 156 8 prominent prominent JJ cord-015021-pol2qm74 156 9 activation activation NN cord-015021-pol2qm74 156 10 of of IN cord-015021-pol2qm74 156 11 coagulation coagulation NN cord-015021-pol2qm74 156 12 . . . cord-015021-pol2qm74 157 1 Even even RB cord-015021-pol2qm74 157 2 in in IN cord-015021-pol2qm74 157 3 this this DT cord-015021-pol2qm74 157 4 post post JJ cord-015021-pol2qm74 157 5 - - JJ cord-015021-pol2qm74 157 6 treatment treatment JJ cord-015021-pol2qm74 157 7 regimen regimen NN cord-015021-pol2qm74 157 8 rec rec NNP cord-015021-pol2qm74 157 9 . . . cord-015021-pol2qm74 158 1 Hirudin Hirudin NNP cord-015021-pol2qm74 158 2 significantly significantly RB cord-015021-pol2qm74 158 3 prevented prevent VBD cord-015021-pol2qm74 158 4 disseminated disseminate VBN cord-015021-pol2qm74 158 5 clotting clotting NN cord-015021-pol2qm74 158 6 . . . cord-015021-pol2qm74 159 1 Hence hence RB cord-015021-pol2qm74 159 2 , , , cord-015021-pol2qm74 159 3 it -PRON- PRP cord-015021-pol2qm74 159 4 was be VBD cord-015021-pol2qm74 159 5 concluded conclude VBN cord-015021-pol2qm74 159 6 , , , cord-015021-pol2qm74 159 7 that that DT cord-015021-pol2qm74 159 8 rec rec NNP cord-015021-pol2qm74 159 9 . . . cord-015021-pol2qm74 160 1 Hirudin Hirudin NNP cord-015021-pol2qm74 160 2 by by IN cord-015021-pol2qm74 160 3 inkihiting inkihite VBG cord-015021-pol2qm74 160 4 thrombin thrombin NN cord-015021-pol2qm74 160 5 could could MD cord-015021-pol2qm74 160 6 be be VB cord-015021-pol2qm74 160 7 effective effective JJ cord-015021-pol2qm74 160 8 in in IN cord-015021-pol2qm74 160 9 the the DT cord-015021-pol2qm74 160 10 prevention prevention NN cord-015021-pol2qm74 160 11 of of IN cord-015021-pol2qm74 160 12 coagulation coagulation NN cord-015021-pol2qm74 160 13 disorders disorder NNS cord-015021-pol2qm74 160 14 including include VBG cord-015021-pol2qm74 160 15 disseminated disseminate VBN cord-015021-pol2qm74 160 16 intravascular intravascular JJ cord-015021-pol2qm74 160 17 clotting clotting NN cord-015021-pol2qm74 160 18 ( ( -LRB- cord-015021-pol2qm74 160 19 DIC DIC NNP cord-015021-pol2qm74 160 20 ) ) -RRB- cord-015021-pol2qm74 160 21 induced induce VBN cord-015021-pol2qm74 160 22 by by IN cord-015021-pol2qm74 160 23 a a DT cord-015021-pol2qm74 160 24 septic septic JJ cord-015021-pol2qm74 160 25 disease disease NN cord-015021-pol2qm74 160 26 . . . cord-015021-pol2qm74 161 1 Research research NN cord-015021-pol2qm74 161 2 Laboratories Laboratories NNPS cord-015021-pol2qm74 161 3 of of IN cord-015021-pol2qm74 161 4 Behringwerke Behringwerke NNP cord-015021-pol2qm74 161 5 AG AG NNP cord-015021-pol2qm74 161 6 , , , cord-015021-pol2qm74 161 7 35001 35001 CD cord-015021-pol2qm74 161 8 Marburg Marburg NNP cord-015021-pol2qm74 161 9 , , , cord-015021-pol2qm74 161 10 Germany Germany NNP cord-015021-pol2qm74 161 11 $ $ $ cord-015021-pol2qm74 161 12 3 3 CD cord-015021-pol2qm74 161 13 Novel Novel NNP cord-015021-pol2qm74 161 14 Protease Protease NNP cord-015021-pol2qm74 161 15 Inhibitory Inhibitory NNP cord-015021-pol2qm74 161 16 Activities Activities NNPS cord-015021-pol2qm74 161 17 of of IN cord-015021-pol2qm74 161 18 the the DT cord-015021-pol2qm74 161 19 Second Second NNP cord-015021-pol2qm74 161 20 Domain Domain NNP cord-015021-pol2qm74 161 21 of of IN cord-015021-pol2qm74 161 22 Urinary urinary JJ cord-015021-pol2qm74 161 23 Trypsin Trypsin NNP cord-015021-pol2qm74 161 24 Inhibitor Inhibitor NNP cord-015021-pol2qm74 161 25 ( ( -LRB- cord-015021-pol2qm74 161 26 R-020 r-020 NN cord-015021-pol2qm74 161 27 ) ) -RRB- cord-015021-pol2qm74 161 28 and and CC cord-015021-pol2qm74 161 29 its -PRON- PRP$ cord-015021-pol2qm74 161 30 Effect effect NN cord-015021-pol2qm74 161 31 on on IN cord-015021-pol2qm74 161 32 SepNs sepns NN cord-015021-pol2qm74 161 33 - - HYPH cord-015021-pol2qm74 161 34 lnduced lnduce VBN cord-015021-pol2qm74 161 35 Organ Organ NNP cord-015021-pol2qm74 161 36 Injury Injury NNP cord-015021-pol2qm74 161 37 in in IN cord-015021-pol2qm74 161 38 Rat Rat NNP cord-015021-pol2qm74 161 39 Atsuo Atsuo NNP cord-015021-pol2qm74 161 40 Murata Murata NNP cord-015021-pol2qm74 161 41 1 1 CD cord-015021-pol2qm74 161 42 , , , cord-015021-pol2qm74 161 43 Hitoshi Hitoshi NNP cord-015021-pol2qm74 161 44 Toda Toda NNP cord-015021-pol2qm74 161 45 1 1 CD cord-015021-pol2qm74 161 46 , , , cord-015021-pol2qm74 162 1 Ken'ichi Ken'ichi NNP cord-015021-pol2qm74 162 2 Uda Uda NNP cord-015021-pol2qm74 162 3 1 1 CD cord-015021-pol2qm74 162 4 , , , cord-015021-pol2qm74 162 5 Hidewaki Hidewaki NNP cord-015021-pol2qm74 162 6 Nakagawa Nakagawa NNP cord-015021-pol2qm74 162 7 1 1 CD cord-015021-pol2qm74 162 8 , , , cord-015021-pol2qm74 162 9 Takesada Takesada NNP cord-015021-pol2qm74 162 10 Mori Mori NNP cord-015021-pol2qm74 162 11 1 1 CD cord-015021-pol2qm74 162 12 , , , cord-015021-pol2qm74 162 13 Hideaki Hideaki NNP cord-015021-pol2qm74 162 14 Morishita Morishita NNP cord-015021-pol2qm74 162 15 2 2 CD cord-015021-pol2qm74 162 16 , , , cord-015021-pol2qm74 162 17 Tom Tom NNP cord-015021-pol2qm74 162 18 Yamakawa Yamakawa NNP cord-015021-pol2qm74 162 19 2 2 CD cord-015021-pol2qm74 162 20 , , , cord-015021-pol2qm74 162 21 Jiro Jiro NNP cord-015021-pol2qm74 162 22 Hirese Hirese NNP cord-015021-pol2qm74 162 23 2 2 CD cord-015021-pol2qm74 162 24 , , , cord-015021-pol2qm74 162 25 Atsushi Atsushi NNP cord-015021-pol2qm74 162 26 Ni~ Ni~ NNP cord-015021-pol2qm74 162 27 2 2 CD cord-015021-pol2qm74 162 28 , , , cord-015021-pol2qm74 162 29 Nariaki Nariaki NNP cord-015021-pol2qm74 162 30 Matsuura Matsuura NNP cord-015021-pol2qm74 162 31 3 3 CD cord-015021-pol2qm74 162 32 1Osaka 1Osaka NNP cord-015021-pol2qm74 162 33 University University NNP cord-015021-pol2qm74 162 34 Medical Medical NNP cord-015021-pol2qm74 162 35 School School NNP cord-015021-pol2qm74 162 36 , , , cord-015021-pol2qm74 162 37 Osaka Osaka NNP cord-015021-pol2qm74 162 38 , , , cord-015021-pol2qm74 163 1 2Mochida 2mochida CD cord-015021-pol2qm74 163 2 Pharmaceutical Pharmaceutical NNP cord-015021-pol2qm74 163 3 Co. Co. NNP cord-015021-pol2qm74 163 4 Ltd. Ltd. NNP cord-015021-pol2qm74 163 5 Tokyo Tokyo NNP cord-015021-pol2qm74 163 6 , , , cord-015021-pol2qm74 163 7 3Wakayama 3Wakayama NNP cord-015021-pol2qm74 163 8 Medical Medical NNP cord-015021-pol2qm74 163 9 Schoof Schoof NNP cord-015021-pol2qm74 163 10 , , , cord-015021-pol2qm74 163 11 Wakayama Wakayama NNP cord-015021-pol2qm74 163 12 , , , cord-015021-pol2qm74 163 13 Japan Japan NNP cord-015021-pol2qm74 163 14 Inhibitory Inhibitory NNP cord-015021-pol2qm74 163 15 - - HYPH cord-015021-pol2qm74 163 16 activities activity NNS cord-015021-pol2qm74 163 17 of of IN cord-015021-pol2qm74 163 18 the the DT cord-015021-pol2qm74 163 19 second second JJ cord-015021-pol2qm74 163 20 KuNtz KuNtz NNP cord-015021-pol2qm74 163 21 - - HYPH cord-015021-pol2qm74 163 22 type type NN cord-015021-pol2qm74 163 23 inhibitor inhibitor NN cord-015021-pol2qm74 163 24 domain domain NN cord-015021-pol2qm74 163 25 of of IN cord-015021-pol2qm74 163 26 human human JJ cord-015021-pol2qm74 163 27 urinary urinary JJ cord-015021-pol2qm74 163 28 trypsin trypsin NN cord-015021-pol2qm74 163 29 inhibitor inhibitor NN cord-015021-pol2qm74 163 30 ( ( -LRB- cord-015021-pol2qm74 163 31 UTI UTI NNP cord-015021-pol2qm74 163 32 ) ) -RRB- cord-015021-pol2qm74 163 33 and and CC cord-015021-pol2qm74 163 34 its -PRON- PRP$ cord-015021-pol2qm74 163 35 effect effect NN cord-015021-pol2qm74 163 36 on on IN cord-015021-pol2qm74 163 37 sepsis sepsis NN cord-015021-pol2qm74 163 38 - - HYPH cord-015021-pol2qm74 163 39 induced induce VBN cord-015021-pol2qm74 163 40 organ organ NN cord-015021-pol2qm74 163 41 injury injury NN cord-015021-pol2qm74 163 42 in in IN cord-015021-pol2qm74 163 43 rat rat NN cord-015021-pol2qm74 163 44 were be VBD cord-015021-pol2qm74 163 45 investigated investigate VBN cord-015021-pol2qm74 163 46 by by IN cord-015021-pol2qm74 163 47 using use VBG cord-015021-pol2qm74 163 48 the the DT cord-015021-pol2qm74 163 49 recombinant recombinant JJ cord-015021-pol2qm74 163 50 protein protein NN cord-015021-pol2qm74 163 51 . . . cord-015021-pol2qm74 164 1 UTI UTI NNP cord-015021-pol2qm74 164 2 is be VBZ cord-015021-pol2qm74 164 3 a a DT cord-015021-pol2qm74 164 4 glycoprotein glycoprotein NN cord-015021-pol2qm74 164 5 with with IN cord-015021-pol2qm74 164 6 a a DT cord-015021-pol2qm74 164 7 structure structure NN cord-015021-pol2qm74 164 8 in in IN cord-015021-pol2qm74 164 9 which which WDT cord-015021-pol2qm74 164 10 2 2 CD cord-015021-pol2qm74 164 11 Kunitz Kunitz NNP cord-015021-pol2qm74 164 12 - - HYPH cord-015021-pol2qm74 164 13 type type NN cord-015021-pol2qm74 164 14 inhibitor inhibitor NN cord-015021-pol2qm74 164 15 domains domain NNS cord-015021-pol2qm74 164 16 are be VBP cord-015021-pol2qm74 164 17 linked link VBN cord-015021-pol2qm74 164 18 in in IN cord-015021-pol2qm74 164 19 a a DT cord-015021-pol2qm74 164 20 row row NN cord-015021-pol2qm74 164 21 . . . cord-015021-pol2qm74 165 1 We -PRON- PRP cord-015021-pol2qm74 165 2 isolated isolate VBD cord-015021-pol2qm74 165 3 the the DT cord-015021-pol2qm74 165 4 gene gene NN cord-015021-pol2qm74 165 5 encoding encode VBG cord-015021-pol2qm74 165 6 the the DT cord-015021-pol2qm74 165 7 second second JJ cord-015021-pol2qm74 165 8 Kunitz Kunitz NNP cord-015021-pol2qm74 165 9 - - HYPH cord-015021-pol2qm74 165 10 type type NN cord-015021-pol2qm74 165 11 inhibitor inhibitor NN cord-015021-pol2qm74 165 12 domain domain NN cord-015021-pol2qm74 165 13 of of IN cord-015021-pol2qm74 165 14 UTI UTI NNP cord-015021-pol2qm74 165 15 , , , cord-015021-pol2qm74 165 16 and and CC cord-015021-pol2qm74 165 17 then then RB cord-015021-pol2qm74 165 18 constructed construct VBN cord-015021-pol2qm74 165 19 expression expression NN cord-015021-pol2qm74 165 20 plasmids plasmid NNS cord-015021-pol2qm74 165 21 by by IN cord-015021-pol2qm74 165 22 ligating ligate VBG cord-015021-pol2qm74 165 23 it -PRON- PRP cord-015021-pol2qm74 165 24 to to IN cord-015021-pol2qm74 165 25 the the DT cord-015021-pol2qm74 165 26 E. E. NNP cord-015021-pol2qm74 165 27 coli coli NNS cord-015021-pol2qm74 165 28 PhoA PhoA NNP cord-015021-pol2qm74 165 29 signal signal NN cord-015021-pol2qm74 165 30 peptide peptide NN cord-015021-pol2qm74 165 31 gene gene NN cord-015021-pol2qm74 165 32 . . . cord-015021-pol2qm74 166 1 These these DT cord-015021-pol2qm74 166 2 plasmids plasmid NNS cord-015021-pol2qm74 166 3 expressed express VBD cord-015021-pol2qm74 166 4 the the DT cord-015021-pol2qm74 166 5 second second JJ cord-015021-pol2qm74 166 6 domain domain NN cord-015021-pol2qm74 166 7 in in IN cord-015021-pol2qm74 166 8 E. E. NNP cord-015021-pol2qm74 166 9 coil coil NN cord-015021-pol2qm74 166 10 strain strain VB cord-015021-pol2qm74 166 11 JE5505 je5505 NN cord-015021-pol2qm74 166 12 which which WDT cord-015021-pol2qm74 166 13 lacks lack VBZ cord-015021-pol2qm74 166 14 the the DT cord-015021-pol2qm74 166 15 membrane membrane NN cord-015021-pol2qm74 166 16 lipoprotein lipoprotein NN cord-015021-pol2qm74 166 17 . . . cord-015021-pol2qm74 167 1 The the DT cord-015021-pol2qm74 167 2 recombinant recombinant JJ cord-015021-pol2qm74 167 3 second second JJ cord-015021-pol2qm74 167 4 domain domain NN cord-015021-pol2qm74 167 5 ( ( -LRB- cord-015021-pol2qm74 167 6 R-020 r-020 NN cord-015021-pol2qm74 167 7 ) ) -RRB- cord-015021-pol2qm74 167 8 inNb[ted innb[ted CD cord-015021-pol2qm74 167 9 trypsin trypsin NN cord-015021-pol2qm74 167 10 , , , cord-015021-pol2qm74 167 11 plasmin plasmin NN cord-015021-pol2qm74 167 12 , , , cord-015021-pol2qm74 167 13 neutrophil neutrophil NN cord-015021-pol2qm74 167 14 elastase elastase NN cord-015021-pol2qm74 167 15 and and CC cord-015021-pol2qm74 167 16 chymotrypsin chymotrypsin NNP cord-015021-pol2qm74 167 17 . . . cord-015021-pol2qm74 168 1 In in IN cord-015021-pol2qm74 168 2 addition addition NN cord-015021-pol2qm74 168 3 it -PRON- PRP cord-015021-pol2qm74 168 4 inhibited inhibit VBD cord-015021-pol2qm74 168 5 blood blood NN cord-015021-pol2qm74 168 6 coagulation coagulation NN cord-015021-pol2qm74 168 7 factor factor NN cord-015021-pol2qm74 169 1 Xa Xa NNP cord-015021-pol2qm74 169 2 and and CC cord-015021-pol2qm74 169 3 plasma plasma NNP cord-015021-pol2qm74 169 4 kallikrein kallikrein NNP cord-015021-pol2qm74 169 5 in in IN cord-015021-pol2qm74 169 6 a a DT cord-015021-pol2qm74 169 7 concentration concentration NN cord-015021-pol2qm74 169 8 dependent dependent JJ cord-015021-pol2qm74 169 9 and and CC cord-015021-pol2qm74 169 10 competitive competitive JJ cord-015021-pol2qm74 169 11 manner manner NN cord-015021-pol2qm74 169 12 . . . cord-015021-pol2qm74 170 1 The the DT cord-015021-pol2qm74 170 2 in in IN cord-015021-pol2qm74 170 3 vivo vivo NN cord-015021-pol2qm74 170 4 effect effect NN cord-015021-pol2qm74 170 5 of of IN cord-015021-pol2qm74 170 6 the the DT cord-015021-pol2qm74 170 7 recombinant recombinant JJ cord-015021-pol2qm74 170 8 R-020 r-020 NN cord-015021-pol2qm74 170 9 was be VBD cord-015021-pol2qm74 170 10 investigated investigate VBN cord-015021-pol2qm74 170 11 in in IN cord-015021-pol2qm74 170 12 a a DT cord-015021-pol2qm74 170 13 rat rat NN cord-015021-pol2qm74 170 14 model model NN cord-015021-pol2qm74 170 15 of of IN cord-015021-pol2qm74 170 16 septic septic JJ cord-015021-pol2qm74 170 17 shock shock NN cord-015021-pol2qm74 170 18 induced induce VBN cord-015021-pol2qm74 170 19 by by IN cord-015021-pol2qm74 170 20 cecal cecal JJ cord-015021-pol2qm74 170 21 ligation ligation NN cord-015021-pol2qm74 170 22 and and CC cord-015021-pol2qm74 170 23 puncture puncture NN cord-015021-pol2qm74 170 24 . . . cord-015021-pol2qm74 171 1 The the DT cord-015021-pol2qm74 171 2 administration administration NN cord-015021-pol2qm74 171 3 of of IN cord-015021-pol2qm74 171 4 R-020 r-020 NN cord-015021-pol2qm74 171 5 significantly significantly RB cord-015021-pol2qm74 171 6 improved improve VBD cord-015021-pol2qm74 171 7 the the DT cord-015021-pol2qm74 171 8 survival survival NN cord-015021-pol2qm74 171 9 rate rate NN cord-015021-pol2qm74 171 10 of of IN cord-015021-pol2qm74 171 11 the the DT cord-015021-pol2qm74 171 12 rats rat NNS cord-015021-pol2qm74 171 13 and and CC cord-015021-pol2qm74 171 14 attenuated attenuate VBD cord-015021-pol2qm74 171 15 the the DT cord-015021-pol2qm74 171 16 pathological pathological JJ cord-015021-pol2qm74 171 17 changes change NNS cord-015021-pol2qm74 171 18 of of IN cord-015021-pol2qm74 171 19 lung lung NN cord-015021-pol2qm74 171 20 and and CC cord-015021-pol2qm74 171 21 iiver iiver NNP cord-015021-pol2qm74 171 22 . . . cord-015021-pol2qm74 172 1 We -PRON- PRP cord-015021-pol2qm74 172 2 found find VBD cord-015021-pol2qm74 172 3 out out RP cord-015021-pol2qm74 172 4 the the DT cord-015021-pol2qm74 172 5 novel novel JJ cord-015021-pol2qm74 172 6 protease protease NN cord-015021-pol2qm74 172 7 inhibitory inhibitory JJ cord-015021-pol2qm74 172 8 activities activity NNS cord-015021-pol2qm74 172 9 of of IN cord-015021-pol2qm74 172 10 the the DT cord-015021-pol2qm74 172 11 second second JJ cord-015021-pol2qm74 172 12 domain domain NN cord-015021-pol2qm74 172 13 of of IN cord-015021-pol2qm74 172 14 UTI UTI NNP cord-015021-pol2qm74 172 15 and and CC cord-015021-pol2qm74 172 16 its -PRON- PRP$ cord-015021-pol2qm74 172 17 protective protective JJ cord-015021-pol2qm74 172 18 effects effect NNS cord-015021-pol2qm74 172 19 on on IN cord-015021-pol2qm74 172 20 sepsis sepsis NN cord-015021-pol2qm74 172 21 - - HYPH cord-015021-pol2qm74 172 22 induced induce VBN cord-015021-pol2qm74 172 23 organ organ NN cord-015021-pol2qm74 172 24 injury injury NN cord-015021-pol2qm74 172 25 . . . cord-015021-pol2qm74 173 1 Macrophages macrophage NNS cord-015021-pol2qm74 173 2 are be VBP cord-015021-pol2qm74 173 3 known know VBN cord-015021-pol2qm74 173 4 to to TO cord-015021-pol2qm74 173 5 secrete secrete VB cord-015021-pol2qm74 173 6 lysosomal lysosomal JJ cord-015021-pol2qm74 173 7 proteinases proteinase NNS cord-015021-pol2qm74 173 8 , , , cord-015021-pol2qm74 173 9 mainly mainly RB cord-015021-pol2qm74 173 10 cathepsin cathepsin NN cord-015021-pol2qm74 173 11 B b NN cord-015021-pol2qm74 173 12 and and CC cord-015021-pol2qm74 173 13 cathepsin cathepsin NN cord-015021-pol2qm74 173 14 L l NN cord-015021-pol2qm74 173 15 , , , cord-015021-pol2qm74 173 16 and and CC cord-015021-pol2qm74 173 17 also also RB cord-015021-pol2qm74 173 18 ~-proteinase ~-proteinase NFP cord-015021-pol2qm74 174 1 inhibitor inhibitor NN cord-015021-pol2qm74 174 2 ( ( -LRB- cord-015021-pol2qm74 174 3 PI),related pi),relate VBN cord-015021-pol2qm74 174 4 to to IN cord-015021-pol2qm74 174 5 acute acute JJ cord-015021-pol2qm74 174 6 phase phase NN cord-015021-pol2qm74 174 7 proteins protein NNS cord-015021-pol2qm74 174 8 . . . cord-015021-pol2qm74 175 1 Disturbances disturbance NNS cord-015021-pol2qm74 175 2 of of IN cord-015021-pol2qm74 175 3 proteinases/ proteinases/ CD cord-015021-pol2qm74 175 4 proteinase proteinase NN cord-015021-pol2qm74 175 5 inhibitors inhibitor NNS cord-015021-pol2qm74 175 6 correlates correlate VBZ cord-015021-pol2qm74 175 7 with with IN cord-015021-pol2qm74 175 8 inflammatory inflammatory JJ cord-015021-pol2qm74 175 9 process process NN cord-015021-pol2qm74 175 10 , , , cord-015021-pol2qm74 175 11 leading lead VBG cord-015021-pol2qm74 175 12 sometimes sometimes RB cord-015021-pol2qm74 175 13 to to TO cord-015021-pol2qm74 175 14 noncontrol noncontrol VB cord-015021-pol2qm74 175 15 " " `` cord-015021-pol2qm74 175 16 pathGlogical pathglogical JJ cord-015021-pol2qm74 175 17 " " '' cord-015021-pol2qm74 175 18 proteolysis proteolysis NN cord-015021-pol2qm74 176 1 ( ( -LRB- cord-015021-pol2qm74 176 2 Jochum Jochum NNP cord-015021-pol2qm74 176 3 et et FW cord-015021-pol2qm74 176 4 ai ai NNP cord-015021-pol2qm74 176 5 . . . cord-015021-pol2qm74 176 6 ,1990 ,1990 , cord-015021-pol2qm74 176 7 ) ) -RRB- cord-015021-pol2qm74 176 8 . . . cord-015021-pol2qm74 177 1 The the DT cord-015021-pol2qm74 177 2 cathepsin cathepsin NN cord-015021-pol2qm74 177 3 L l NN cord-015021-pol2qm74 177 4 - - HYPH cord-015021-pol2qm74 177 5 like like JJ cord-015021-pol2qm74 177 6 and and CC cord-015021-pol2qm74 177 7 cathepsin cathepsin NN cord-015021-pol2qm74 177 8 B b NN cord-015021-pol2qm74 177 9 - - HYPH cord-015021-pol2qm74 177 10 like like JJ cord-015021-pol2qm74 177 11 activity activity NN cord-015021-pol2qm74 177 12 were be VBD cord-015021-pol2qm74 177 13 measured measure VBN cord-015021-pol2qm74 177 14 in in IN cord-015021-pol2qm74 177 15 serum serum NN cord-015021-pol2qm74 177 16 of of IN cord-015021-pol2qm74 177 17 42 42 CD cord-015021-pol2qm74 177 18 patients patient NNS cord-015021-pol2qm74 177 19 with with IN cord-015021-pol2qm74 177 20 chronic chronic JJ cord-015021-pol2qm74 177 21 bronchitis bronchitis NN cord-015021-pol2qm74 177 22 ( ( -LRB- cord-015021-pol2qm74 177 23 14 14 CD cord-015021-pol2qm74 177 24 -with -with CD cord-015021-pol2qm74 177 25 obstructive obstructive JJ cord-015021-pol2qm74 177 26 , , , cord-015021-pol2qm74 177 27 28 28 CD cord-015021-pol2qm74 177 28 -with -with CD cord-015021-pol2qm74 177 29 nonobstructive nonobstructive JJ cord-015021-pol2qm74 177 30 bronchitis),acute bronchitis),acute NNP cord-015021-pol2qm74 177 31 bronchitis bronchitis NN cord-015021-pol2qm74 177 32 ( ( -LRB- cord-015021-pol2qm74 177 33 15 15 CD cord-015021-pol2qm74 177 34 ) ) -RRB- cord-015021-pol2qm74 177 35 and and CC cord-015021-pol2qm74 177 36 35 35 CD cord-015021-pol2qm74 177 37 healthy healthy JJ cord-015021-pol2qm74 177 38 persons person NNS cord-015021-pol2qm74 177 39 . . . cord-015021-pol2qm74 178 1 Simultaneously simultaneously RB cord-015021-pol2qm74 178 2 the the DT cord-015021-pol2qm74 178 3 level level NN cord-015021-pol2qm74 178 4 of of IN cord-015021-pol2qm74 178 5 ~ ~ NFP cord-015021-pol2qm74 178 6 PI PI NNP cord-015021-pol2qm74 178 7 was be VBD cord-015021-pol2qm74 178 8 determined determine VBN cord-015021-pol2qm74 178 9 in in IN cord-015021-pol2qm74 178 10 the the DT cord-015021-pol2qm74 178 11 same same JJ cord-015021-pol2qm74 178 12 groups group NNS cord-015021-pol2qm74 178 13 . . . cord-015021-pol2qm74 179 1 Cysteine cysteine NN cord-015021-pol2qm74 179 2 proteinases proteinase NNS cord-015021-pol2qm74 179 3 were be VBD cord-015021-pol2qm74 179 4 measured measure VBN cord-015021-pol2qm74 179 5 with with IN cord-015021-pol2qm74 179 6 help help NN cord-015021-pol2qm74 179 7 of of IN cord-015021-pol2qm74 179 8 fluorogenic fluorogenic JJ cord-015021-pol2qm74 179 9 substrates substrate NNS cord-015021-pol2qm74 179 10 , , , cord-015021-pol2qm74 179 11 as as IN cord-015021-pol2qm74 179 12 was be VBD cord-015021-pol2qm74 179 13 presented present VBN cord-015021-pol2qm74 179 14 earlier early RBR cord-015021-pol2qm74 180 1 ( ( -LRB- cord-015021-pol2qm74 180 2 Korolenko Korolenko NNP cord-015021-pol2qm74 180 3 et et NNP cord-015021-pol2qm74 180 4 ai ai NNP cord-015021-pol2qm74 180 5 . . . cord-015021-pol2qm74 180 6 ,1991 ,1991 , cord-015021-pol2qm74 180 7 ) ) -RRB- cord-015021-pol2qm74 180 8 , , . cord-015021-pol2qm74 181 1 ~PI ~PI . cord-015021-pol2qm74 182 1 with with IN cord-015021-pol2qm74 182 2 help help NN cord-015021-pol2qm74 182 3 of of IN cord-015021-pol2qm74 182 4 immune immune JJ cord-015021-pol2qm74 182 5 enzyme enzyme NN cord-015021-pol2qm74 182 6 method method NN cord-015021-pol2qm74 182 7 . . . cord-015021-pol2qm74 183 1 It -PRON- PRP cord-015021-pol2qm74 183 2 was be VBD cord-015021-pol2qm74 183 3 shown show VBN cord-015021-pol2qm74 183 4 increase increase NN cord-015021-pol2qm74 183 5 of of IN cord-015021-pol2qm74 183 6 cathepsin cathepsin NN cord-015021-pol2qm74 183 7 L l NN cord-015021-pol2qm74 183 8 - - HYPH cord-015021-pol2qm74 183 9 like like JJ cord-015021-pol2qm74 183 10 and and CC cord-015021-pol2qm74 183 11 cathepsin cathepsin NN cord-015021-pol2qm74 183 12 B b NN cord-015021-pol2qm74 183 13 - - HYPH cord-015021-pol2qm74 183 14 like like JJ cord-015021-pol2qm74 183 15 activities activity NNS cord-015021-pol2qm74 183 16 during during IN cord-015021-pol2qm74 183 17 aggravation aggravation NN cord-015021-pol2qm74 183 18 of of IN cord-015021-pol2qm74 183 19 chronic chronic JJ cord-015021-pol2qm74 183 20 bronchitis bronchitis NN cord-015021-pol2qm74 183 21 comparatively comparatively RB cord-015021-pol2qm74 183 22 to to IN cord-015021-pol2qm74 183 23 the the DT cord-015021-pol2qm74 183 24 controls control NNS cord-015021-pol2qm74 183 25 ( ( -LRB- cord-015021-pol2qm74 183 26 2 2 CD cord-015021-pol2qm74 183 27 - - SYM cord-015021-pol2qm74 183 28 4 4 CD cord-015021-pol2qm74 183 29 fold fold NN cord-015021-pol2qm74 183 30 ) ) -RRB- cord-015021-pol2qm74 184 1 .After .After NFP cord-015021-pol2qm74 184 2 treatment treatment NN cord-015021-pol2qm74 184 3 there there EX cord-015021-pol2qm74 184 4 was be VBD cord-015021-pol2qm74 184 5 a a DT cord-015021-pol2qm74 184 6 tendency tendency NN cord-015021-pol2qm74 184 7 to to IN cord-015021-pol2qm74 184 8 normalization normalization NN cord-015021-pol2qm74 184 9 of of IN cord-015021-pol2qm74 184 10 indices index NNS cord-015021-pol2qm74 184 11 , , , cord-015021-pol2qm74 184 12 but but CC cord-015021-pol2qm74 184 13 the the DT cord-015021-pol2qm74 184 14 increase increase NN cord-015021-pol2qm74 184 15 was be VBD cord-015021-pol2qm74 184 16 about about RB cord-015021-pol2qm74 184 17 30 30 CD cord-015021-pol2qm74 184 18 - - SYM cord-015021-pol2qm74 184 19 40 40 CD cord-015021-pol2qm74 184 20 % % NN cord-015021-pol2qm74 184 21 more more JJR cord-015021-pol2qm74 184 22 than than IN cord-015021-pol2qm74 184 23 the the DT cord-015021-pol2qm74 184 24 control control NN cord-015021-pol2qm74 184 25 values.~PI values.~pi IN cord-015021-pol2qm74 184 26 level level NN cord-015021-pol2qm74 184 27 in in IN cord-015021-pol2qm74 184 28 this this DT cord-015021-pol2qm74 184 29 group group NN cord-015021-pol2qm74 184 30 was be VBD cord-015021-pol2qm74 184 31 also also RB cord-015021-pol2qm74 184 32 increased increase VBN cord-015021-pol2qm74 185 1 ( ( -LRB- cord-015021-pol2qm74 185 2 two two CD cord-015021-pol2qm74 185 3 - - HYPH cord-015021-pol2qm74 185 4 fold),in fold),in NN cord-015021-pol2qm74 185 5 patients patient NNS cord-015021-pol2qm74 185 6 with with IN cord-015021-pol2qm74 185 7 acute acute JJ cord-015021-pol2qm74 185 8 bronchitis bronchitis NN cord-015021-pol2qm74 185 9 -2 -2 NN cord-015021-pol2qm74 185 10 - - : cord-015021-pol2qm74 185 11 4-times 4-times CD cord-015021-pol2qm74 185 12 more more RBR cord-015021-pol2qm74 185 13 comparatively comparatively RB cord-015021-pol2qm74 185 14 to to IN cord-015021-pol2qm74 185 15 the the DT cord-015021-pol2qm74 185 16 control control NN cord-015021-pol2qm74 185 17 . . . cord-015021-pol2qm74 186 1 It -PRON- PRP cord-015021-pol2qm74 186 2 is be VBZ cord-015021-pol2qm74 186 3 possible possible JJ cord-015021-pol2qm74 186 4 to to TO cord-015021-pol2qm74 186 5 conclude conclude VB cord-015021-pol2qm74 186 6 that that IN cord-015021-pol2qm74 186 7 chronic chronic JJ cord-015021-pol2qm74 186 8 bronchitis bronchitis NN cord-015021-pol2qm74 186 9 induced induce VBN cord-015021-pol2qm74 186 10 increased increase VBD cord-015021-pol2qm74 186 11 secretion secretion NN cord-015021-pol2qm74 186 12 both both DT cord-015021-pol2qm74 186 13 cysteine cysteine NN cord-015021-pol2qm74 186 14 proteinases proteinase NNS cord-015021-pol2qm74 186 15 and and CC cord-015021-pol2qm74 186 16 d{PI d{pi NN cord-015021-pol2qm74 186 17 into into IN cord-015021-pol2qm74 186 18 blood blood NN cord-015021-pol2qm74 186 19 . . . cord-015021-pol2qm74 187 1 Some some DT cord-015021-pol2qm74 187 2 peculiarities peculiarity NNS cord-015021-pol2qm74 187 3 of of IN cord-015021-pol2qm74 187 4 ratio ratio NN cord-015021-pol2qm74 187 5 were be VBD cord-015021-pol2qm74 187 6 noted note VBN cord-015021-pol2qm74 187 7 in in IN cord-015021-pol2qm74 187 8 patients patient NNS cord-015021-pol2qm74 187 9 with with IN cord-015021-pol2qm74 187 10 emphysema emphysema NN cord-015021-pol2qm74 187 11 . . . cord-015021-pol2qm74 188 1 Endotoxins endotoxin NNS cord-015021-pol2qm74 188 2 are be VBP cord-015021-pol2qm74 188 3 microbial microbial JJ cord-015021-pol2qm74 188 4 products product NNS cord-015021-pol2qm74 188 5 derived derive VBN cord-015021-pol2qm74 188 6 from from IN cord-015021-pol2qm74 188 7 the the DT cord-015021-pol2qm74 188 8 outer outer JJ cord-015021-pol2qm74 188 9 cell cell NN cord-015021-pol2qm74 188 10 membrane membrane NN cord-015021-pol2qm74 188 11 of of IN cord-015021-pol2qm74 188 12 Gram Gram NNP cord-015021-pol2qm74 188 13 negative negative JJ cord-015021-pol2qm74 188 14 bacteria bacteria NNS cord-015021-pol2qm74 188 15 . . . cord-015021-pol2qm74 189 1 The the DT cord-015021-pol2qm74 189 2 active active JJ cord-015021-pol2qm74 189 3 component component NN cord-015021-pol2qm74 189 4 of of IN cord-015021-pol2qm74 189 5 endotoxin endotoxin NN cord-015021-pol2qm74 189 6 is be VBZ cord-015021-pol2qm74 189 7 lipopolysaccharide lipopolysaccharide NN cord-015021-pol2qm74 189 8 ( ( -LRB- cord-015021-pol2qm74 189 9 LPS LPS NNP cord-015021-pol2qm74 189 10 ) ) -RRB- cord-015021-pol2qm74 189 11 , , , cord-015021-pol2qm74 189 12 a a DT cord-015021-pol2qm74 189 13 complex complex JJ cord-015021-pol2qm74 189 14 macromolecule macromolecule NN cord-015021-pol2qm74 189 15 consisting consist VBG cord-015021-pol2qm74 189 16 of of IN cord-015021-pol2qm74 189 17 polysaccharide polysaccharide NN cord-015021-pol2qm74 189 18 covalently covalently RB cord-015021-pol2qm74 189 19 bound bind VBN cord-015021-pol2qm74 189 20 to to IN cord-015021-pol2qm74 189 21 a a DT cord-015021-pol2qm74 189 22 unique unique JJ cord-015021-pol2qm74 189 23 lipid lipid NN cord-015021-pol2qm74 189 24 , , , cord-015021-pol2qm74 189 25 termed term VBD cord-015021-pol2qm74 189 26 lipid lipid NN cord-015021-pol2qm74 189 27 A. a. NN cord-015021-pol2qm74 189 28 Now now RB cord-015021-pol2qm74 189 29 recognized recognize VBN cord-015021-pol2qm74 189 30 to to TO cord-015021-pol2qm74 189 31 embody embody VB cord-015021-pol2qm74 189 32 the the DT cord-015021-pol2qm74 189 33 endotoxic endotoxic JJ cord-015021-pol2qm74 189 34 principle principle NN cord-015021-pol2qm74 189 35 of of IN cord-015021-pol2qm74 189 36 LPS LPS NNP cord-015021-pol2qm74 189 37 , , , cord-015021-pol2qm74 189 38 lipid lipid NN cord-015021-pol2qm74 189 39 A a NN cord-015021-pol2qm74 189 40 consists consists NN cord-015021-pol2qm74 189 41 of of IN cord-015021-pol2qm74 189 42 a/31 a/31 NNP cord-015021-pol2qm74 189 43 - - HYPH cord-015021-pol2qm74 189 44 6 6 CD cord-015021-pol2qm74 189 45 diglucosamine diglucosamine NN cord-015021-pol2qm74 189 46 backbone backbone NN cord-015021-pol2qm74 189 47 , , , cord-015021-pol2qm74 189 48 both both CC cord-015021-pol2qm74 189 49 ester ester NN cord-015021-pol2qm74 189 50 and and CC cord-015021-pol2qm74 189 51 amide amide NN cord-015021-pol2qm74 189 52 linked link VBD cord-015021-pol2qm74 189 53 fatty fatty JJ cord-015021-pol2qm74 189 54 acids acid NNS cord-015021-pol2qm74 189 55 , , , cord-015021-pol2qm74 189 56 some some DT cord-015021-pol2qm74 189 57 of of IN cord-015021-pol2qm74 189 58 which which WDT cord-015021-pol2qm74 189 59 are be VBP cord-015021-pol2qm74 189 60 acyloxyacylated acyloxyacylate VBN cord-015021-pol2qm74 189 61 , , , cord-015021-pol2qm74 189 62 and and CC cord-015021-pol2qm74 189 63 charged charge VBD cord-015021-pol2qm74 189 64 constituents constituent NNS cord-015021-pol2qm74 189 65 such such JJ cord-015021-pol2qm74 189 66 as as IN cord-015021-pol2qm74 189 67 phosphate phosphate NN cord-015021-pol2qm74 189 68 , , , cord-015021-pol2qm74 189 69 phosphorylethanolamine phosphorylethanolamine NN cord-015021-pol2qm74 189 70 and and CC cord-015021-pol2qm74 189 71 4 4 CD cord-015021-pol2qm74 189 72 amino amino JJ cord-015021-pol2qm74 189 73 arbinose arbinose JJ cord-015021-pol2qm74 189 74 LPS lp NNS cord-015021-pol2qm74 189 75 , , , cord-015021-pol2qm74 189 76 exerts exert VBZ cord-015021-pol2qm74 189 77 its -PRON- PRP$ cord-015021-pol2qm74 189 78 biological biological JJ cord-015021-pol2qm74 189 79 effects effect NNS cord-015021-pol2qm74 189 80 in in IN cord-015021-pol2qm74 189 81 vivo vivo NN cord-015021-pol2qm74 189 82 by by IN cord-015021-pol2qm74 189 83 noncytotoxic noncytotoxic NNP cord-015021-pol2qm74 189 84 interactions interaction NNS cord-015021-pol2qm74 189 85 with with IN cord-015021-pol2qm74 189 86 a a DT cord-015021-pol2qm74 189 87 variety variety NN cord-015021-pol2qm74 189 88 of of IN cord-015021-pol2qm74 189 89 host host NN cord-015021-pol2qm74 189 90 inflammatory inflammatory JJ cord-015021-pol2qm74 189 91 mediator mediator NN cord-015021-pol2qm74 189 92 cells cell NNS cord-015021-pol2qm74 189 93 , , , cord-015021-pol2qm74 189 94 primarily primarily RB cord-015021-pol2qm74 189 95 the the DT cord-015021-pol2qm74 189 96 mononuclear mononuclear JJ cord-015021-pol2qm74 189 97 phagocyte phagocyte NNP cord-015021-pol2qm74 189 98 and and CC cord-015021-pol2qm74 189 99 the the DT cord-015021-pol2qm74 189 100 endothelial endothelial JJ cord-015021-pol2qm74 189 101 cell cell NN cord-015021-pol2qm74 189 102 , , , cord-015021-pol2qm74 189 103 although although IN cord-015021-pol2qm74 189 104 other other JJ cord-015021-pol2qm74 189 105 host host NN cord-015021-pol2qm74 189 106 cells cell NNS cord-015021-pol2qm74 189 107 also also RB cord-015021-pol2qm74 189 108 participate participate VBP cord-015021-pol2qm74 189 109 . . . cord-015021-pol2qm74 190 1 These these DT cord-015021-pol2qm74 190 2 interactions interaction NNS cord-015021-pol2qm74 190 3 are be VBP cord-015021-pol2qm74 190 4 modulated modulate VBN cord-015021-pol2qm74 190 5 by by IN cord-015021-pol2qm74 190 6 LPS LPS NNP cord-015021-pol2qm74 190 7 - - HYPH cord-015021-pol2qm74 190 8 specific specific JJ cord-015021-pol2qm74 190 9 binding bind VBG cord-015021-pol2qm74 190 10 proteins protein NNS cord-015021-pol2qm74 190 11 found find VBN cord-015021-pol2qm74 190 12 in in IN cord-015021-pol2qm74 190 13 plasma plasma NN cord-015021-pol2qm74 190 14 , , , cord-015021-pol2qm74 190 15 including include VBG cord-015021-pol2qm74 190 16 LPS lps NN cord-015021-pol2qm74 190 17 - - HYPH cord-015021-pol2qm74 190 18 binding bind VBG cord-015021-pol2qm74 190 19 protein protein NN cord-015021-pol2qm74 190 20 ( ( -LRB- cord-015021-pol2qm74 190 21 LBP LBP NNP cord-015021-pol2qm74 190 22 ) ) -RRB- cord-015021-pol2qm74 190 23 sCD14 scd14 NN cord-015021-pol2qm74 190 24 and and CC cord-015021-pol2qm74 190 25 perhaps perhaps RB cord-015021-pol2qm74 190 26 other other JJ cord-015021-pol2qm74 190 27 proteins protein NNS cord-015021-pol2qm74 190 28 as as RB cord-015021-pol2qm74 190 29 well well RB cord-015021-pol2qm74 190 30 . . . cord-015021-pol2qm74 191 1 Specific specific JJ cord-015021-pol2qm74 191 2 receptors receptor NNS cord-015021-pol2qm74 191 3 for for IN cord-015021-pol2qm74 191 4 LPS lp NNS cord-015021-pol2qm74 191 5 have have VBP cord-015021-pol2qm74 191 6 been be VBN cord-015021-pol2qm74 191 7 identified identify VBN cord-015021-pol2qm74 191 8 on on IN cord-015021-pol2qm74 191 9 mammalian mammalian JJ cord-015021-pol2qm74 191 10 cells cell NNS cord-015021-pol2qm74 191 11 which which WDT cord-015021-pol2qm74 191 12 mediate mediate VBP cord-015021-pol2qm74 191 13 signal signal NN cord-015021-pol2qm74 191 14 transduction transduction NN cord-015021-pol2qm74 191 15 via via IN cord-015021-pol2qm74 191 16 multiple multiple JJ cord-015021-pol2qm74 191 17 pathways pathway NNS cord-015021-pol2qm74 191 18 . . . cord-015021-pol2qm74 192 1 LPS LPS NNP cord-015021-pol2qm74 192 2 - - HYPH cord-015021-pol2qm74 192 3 activated activate VBN cord-015021-pol2qm74 192 4 host host NN cord-015021-pol2qm74 192 5 cells cell NNS cord-015021-pol2qm74 192 6 are be VBP cord-015021-pol2qm74 192 7 stimulated stimulate VBN cord-015021-pol2qm74 192 8 to to TO cord-015021-pol2qm74 192 9 secrete secrete VB cord-015021-pol2qm74 192 10 or or CC cord-015021-pol2qm74 192 11 express express VB cord-015021-pol2qm74 192 12 multiple multiple JJ cord-015021-pol2qm74 192 13 proinflammatory proinflammatory JJ cord-015021-pol2qm74 192 14 mediators mediator NNS cord-015021-pol2qm74 192 15 , , , cord-015021-pol2qm74 192 16 including include VBG cord-015021-pol2qm74 192 17 TNF TNF NNP cord-015021-pol2qm74 192 18 - - HYPH cord-015021-pol2qm74 192 19 a a NNP cord-015021-pol2qm74 192 20 , , , cord-015021-pol2qm74 192 21 ILla ILla NNP cord-015021-pol2qm74 192 22 , , , cord-015021-pol2qm74 192 23 IL-1/3 IL-1/3 NNP cord-015021-pol2qm74 192 24 , , , cord-015021-pol2qm74 192 25 IFN IFN NNP cord-015021-pol2qm74 192 26 - - HYPH cord-015021-pol2qm74 192 27 a a NNP cord-015021-pol2qm74 192 28 , , , cord-015021-pol2qm74 192 29 IL-6 IL-6 NNP cord-015021-pol2qm74 192 30 , , , cord-015021-pol2qm74 192 31 IL-8 IL-8 NNP cord-015021-pol2qm74 192 32 , , , cord-015021-pol2qm74 192 33 IL-10 IL-10 NNP cord-015021-pol2qm74 192 34 , , , cord-015021-pol2qm74 192 35 PAF PAF NNP cord-015021-pol2qm74 192 36 , , , cord-015021-pol2qm74 192 37 PGE PGE NNP cord-015021-pol2qm74 192 38 , , , cord-015021-pol2qm74 192 39 LTB LTB NNP cord-015021-pol2qm74 192 40 4 4 CD cord-015021-pol2qm74 192 41 and and CC cord-015021-pol2qm74 192 42 procoagulant procoagulant NN cord-015021-pol2qm74 192 43 activity activity NN cord-015021-pol2qm74 192 44 . . . cord-015021-pol2qm74 193 1 The the DT cord-015021-pol2qm74 193 2 overproduction overproduction NN cord-015021-pol2qm74 193 3 of of IN cord-015021-pol2qm74 193 4 these these DT cord-015021-pol2qm74 193 5 proinfiammatory proinfiammatory JJ cord-015021-pol2qm74 193 6 mediators mediator NNS cord-015021-pol2qm74 193 7 results result VBZ cord-015021-pol2qm74 193 8 in in IN cord-015021-pol2qm74 193 9 the the DT cord-015021-pol2qm74 193 10 manifestations manifestation NNS cord-015021-pol2qm74 193 11 of of IN cord-015021-pol2qm74 193 12 endotoxemia endotoxemia NN cord-015021-pol2qm74 193 13 , , , cord-015021-pol2qm74 193 14 observed observe VBD cord-015021-pol2qm74 193 15 experimentally experimentally RB cord-015021-pol2qm74 193 16 as as IN cord-015021-pol2qm74 193 17 fever fever NN cord-015021-pol2qm74 193 18 , , , cord-015021-pol2qm74 193 19 hypotension hypotension NN cord-015021-pol2qm74 193 20 , , , cord-015021-pol2qm74 193 21 disseminated disseminate VBN cord-015021-pol2qm74 193 22 intravascular intravascular JJ cord-015021-pol2qm74 193 23 coagulation coagulation NN cord-015021-pol2qm74 193 24 and and CC cord-015021-pol2qm74 193 25 death death NN cord-015021-pol2qm74 193 26 . . . cord-015021-pol2qm74 194 1 Modulation modulation NN cord-015021-pol2qm74 194 2 of of IN cord-015021-pol2qm74 194 3 activity activity NN cord-015021-pol2qm74 194 4 of of IN cord-015021-pol2qm74 194 5 these these DT cord-015021-pol2qm74 194 6 mediators mediator NNS cord-015021-pol2qm74 194 7 protects protect VBZ cord-015021-pol2qm74 194 8 animals animal NNS cord-015021-pol2qm74 194 9 against against IN cord-015021-pol2qm74 194 10 lethality lethality NN cord-015021-pol2qm74 194 11 . . . cord-015021-pol2qm74 195 1 Similar similar JJ cord-015021-pol2qm74 195 2 pathways pathway NNS cord-015021-pol2qm74 195 3 are be VBP cord-015021-pol2qm74 195 4 thought think VBN cord-015021-pol2qm74 195 5 to to TO cord-015021-pol2qm74 195 6 be be VB cord-015021-pol2qm74 195 7 operative operative JJ cord-015021-pol2qm74 195 8 in in IN cord-015021-pol2qm74 195 9 Gram Gram NNP cord-015021-pol2qm74 195 10 negative negative JJ cord-015021-pol2qm74 195 11 sepsis sepsis NN cord-015021-pol2qm74 195 12 , , , cord-015021-pol2qm74 195 13 and and CC cord-015021-pol2qm74 195 14 control control NN cord-015021-pol2qm74 195 15 studies study NNS cord-015021-pol2qm74 195 16 with with IN cord-015021-pol2qm74 195 17 human human JJ cord-015021-pol2qm74 195 18 volunteers volunteer NNS cord-015021-pol2qm74 195 19 support support VBP cord-015021-pol2qm74 195 20 such such JJ cord-015021-pol2qm74 195 21 conclusions conclusion NNS cord-015021-pol2qm74 195 22 . . . cord-015021-pol2qm74 196 1 Immunotherapeutic immunotherapeutic JJ cord-015021-pol2qm74 196 2 approaches approach NNS cord-015021-pol2qm74 196 3 in in IN cord-015021-pol2qm74 196 4 clinical clinical JJ cord-015021-pol2qm74 196 5 Gram Gram NNP cord-015021-pol2qm74 196 6 negative negative JJ cord-015021-pol2qm74 196 7 sepsis sepsis NN cord-015021-pol2qm74 196 8 have have VBP cord-015021-pol2qm74 196 9 , , , cord-015021-pol2qm74 196 10 to to IN cord-015021-pol2qm74 196 11 date date NN cord-015021-pol2qm74 196 12 , , , cord-015021-pol2qm74 196 13 been be VBN cord-015021-pol2qm74 196 14 less less RBR cord-015021-pol2qm74 196 15 successful successful JJ cord-015021-pol2qm74 196 16 . . . cord-015021-pol2qm74 197 1 In in IN cord-015021-pol2qm74 197 2 vitro vitro FW cord-015021-pol2qm74 197 3 experiments experiment NNS cord-015021-pol2qm74 197 4 and and CC cord-015021-pol2qm74 197 5 studies study NNS cord-015021-pol2qm74 197 6 in in IN cord-015021-pol2qm74 197 7 animal animal NN cord-015021-pol2qm74 197 8 models model NNS cord-015021-pol2qm74 197 9 have have VBP cord-015021-pol2qm74 197 10 recently recently RB cord-015021-pol2qm74 197 11 shown show VBN cord-015021-pol2qm74 197 12 that that IN cord-015021-pol2qm74 197 13 several several JJ cord-015021-pol2qm74 197 14 proteinaceous proteinaceous JJ cord-015021-pol2qm74 197 15 bacterial bacterial JJ cord-015021-pol2qm74 197 16 exotoxins exotoxin NNS cord-015021-pol2qm74 197 17 can can MD cord-015021-pol2qm74 197 18 evoke evoke VB cord-015021-pol2qm74 197 19 cytotoxic cytotoxic JJ cord-015021-pol2qm74 197 20 effects effect NNS cord-015021-pol2qm74 197 21 that that WDT cord-015021-pol2qm74 197 22 ultimately ultimately RB cord-015021-pol2qm74 197 23 lead lead VBP cord-015021-pol2qm74 197 24 to to IN cord-015021-pol2qm74 197 25 cardiovascular cardiovascular JJ cord-015021-pol2qm74 197 26 collapse collapse NN cord-015021-pol2qm74 197 27 and and CC cord-015021-pol2qm74 197 28 shock shock NN cord-015021-pol2qm74 197 29 . . . cord-015021-pol2qm74 198 1 Since since IN cord-015021-pol2qm74 198 2 the the DT cord-015021-pol2qm74 198 3 possible possible JJ cord-015021-pol2qm74 198 4 relevance relevance NN cord-015021-pol2qm74 198 5 of of IN cord-015021-pol2qm74 198 6 bacterial bacterial JJ cord-015021-pol2qm74 198 7 exotoxins exotoxin NNS cord-015021-pol2qm74 198 8 in in IN cord-015021-pol2qm74 198 9 the the DT cord-015021-pol2qm74 198 10 pathogenesis pathogenesis NN cord-015021-pol2qm74 198 11 of of IN cord-015021-pol2qm74 198 12 septic septic JJ cord-015021-pol2qm74 198 13 shock shock NN cord-015021-pol2qm74 198 14 has have VBZ cord-015021-pol2qm74 198 15 received receive VBN cord-015021-pol2qm74 198 16 very very RB cord-015021-pol2qm74 198 17 little little JJ cord-015021-pol2qm74 198 18 attention attention NN cord-015021-pol2qm74 198 19 in in IN cord-015021-pol2qm74 198 20 the the DT cord-015021-pol2qm74 198 21 past past NN cord-015021-pol2qm74 198 22 , , , cord-015021-pol2qm74 198 23 an an DT cord-015021-pol2qm74 198 24 attempt attempt NN cord-015021-pol2qm74 198 25 will will MD cord-015021-pol2qm74 198 26 be be VB cord-015021-pol2qm74 198 27 made make VBN cord-015021-pol2qm74 198 28 here here RB cord-015021-pol2qm74 198 29 to to TO cord-015021-pol2qm74 198 30 provide provide VB cord-015021-pol2qm74 198 31 a a DT cord-015021-pol2qm74 198 32 brief brief JJ cord-015021-pol2qm74 198 33 overview overview NN cord-015021-pol2qm74 198 34 of of IN cord-015021-pol2qm74 198 35 this this DT cord-015021-pol2qm74 198 36 generaily generaily RB cord-015021-pol2qm74 198 37 neglected neglect VBD cord-015021-pol2qm74 198 38 topic topic NN cord-015021-pol2qm74 198 39 . . . cord-015021-pol2qm74 199 1 Protein protein NN cord-015021-pol2qm74 199 2 toxins toxin NNS cord-015021-pol2qm74 199 3 act act VBP cord-015021-pol2qm74 199 4 intracellularly intracellularly RB cord-015021-pol2qm74 199 5 or or CC cord-015021-pol2qm74 199 6 they -PRON- PRP cord-015021-pol2qm74 199 7 dz dz NNP cord-015021-pol2qm74 200 1 ~nage ~nage NFP cord-015021-pol2qm74 201 1 the the DT cord-015021-pol2qm74 201 2 integrity integrity NN cord-015021-pol2qm74 201 3 and and CC cord-015021-pol2qm74 201 4 function function NN cord-015021-pol2qm74 201 5 of of IN cord-015021-pol2qm74 201 6 the the DT cord-015021-pol2qm74 201 7 plasma plasma NN cord-015021-pol2qm74 201 8 membrane membrane NN cord-015021-pol2qm74 201 9 . . . cord-015021-pol2qm74 202 1 Major major JJ cord-015021-pol2qm74 202 2 representatives representative NNS cord-015021-pol2qm74 202 3 of of IN cord-015021-pol2qm74 202 4 the the DT cord-015021-pol2qm74 202 5 former former JJ cord-015021-pol2qm74 202 6 group group NN cord-015021-pol2qm74 202 7 are be VBP cord-015021-pol2qm74 202 8 the the DT cord-015021-pol2qm74 202 9 adenosine adenosine NN cord-015021-pol2qm74 202 10 diphosphate diphosphate NN cord-015021-pol2qm74 202 11 ( ( -LRB- cord-015021-pol2qm74 202 12 ADP)-ribosylating adp)-ribosylate VBG cord-015021-pol2qm74 202 13 toxins toxin NNS cord-015021-pol2qm74 202 14 , , , cord-015021-pol2qm74 202 15 e.g. e.g. RB cord-015021-pol2qm74 202 16 cholera cholera NN cord-015021-pol2qm74 202 17 and and CC cord-015021-pol2qm74 202 18 cholera cholera NN cord-015021-pol2qm74 202 19 - - HYPH cord-015021-pol2qm74 202 20 like like JJ cord-015021-pol2qm74 202 21 toxins toxin NNS cord-015021-pol2qm74 202 22 , , , cord-015021-pol2qm74 202 23 diphtheria diphtheria NN cord-015021-pol2qm74 202 24 toxin toxin NN cord-015021-pol2qm74 202 25 ) ) -RRB- cord-015021-pol2qm74 202 26 , , , cord-015021-pol2qm74 202 27 and and CC cord-015021-pol2qm74 202 28 the the DT cord-015021-pol2qm74 202 29 neurotoxins neurotoxin NNS cord-015021-pol2qm74 202 30 . . . cord-015021-pol2qm74 203 1 Most most RBS cord-015021-pol2qm74 203 2 medically medically RB cord-015021-pol2qm74 203 3 relevant relevant JJ cord-015021-pol2qm74 203 4 toxins toxin NNS cord-015021-pol2qm74 203 5 of of IN cord-015021-pol2qm74 203 6 this this DT cord-015021-pol2qm74 203 7 category category NN cord-015021-pol2qm74 203 8 have have VBP cord-015021-pol2qm74 203 9 been be VBN cord-015021-pol2qm74 203 10 studied study VBN cord-015021-pol2qm74 203 11 in in IN cord-015021-pol2qm74 203 12 great great JJ cord-015021-pol2qm74 203 13 detail detail NN cord-015021-pol2qm74 203 14 . . . cord-015021-pol2qm74 204 1 Although although IN cord-015021-pol2qm74 204 2 often often RB cord-015021-pol2qm74 204 3 responsible responsible JJ cord-015021-pol2qm74 204 4 for for IN cord-015021-pol2qm74 204 5 severe severe JJ cord-015021-pol2qm74 204 6 and and CC cord-015021-pol2qm74 204 7 sometimes sometimes RB cord-015021-pol2qm74 204 8 fatal fatal JJ cord-015021-pol2qm74 204 9 disease disease NN cord-015021-pol2qm74 204 10 , , , cord-015021-pol2qm74 204 11 their -PRON- PRP$ cord-015021-pol2qm74 204 12 association association NN cord-015021-pol2qm74 204 13 with with IN cord-015021-pol2qm74 204 14 septic septic JJ cord-015021-pol2qm74 204 15 shock shock NN cord-015021-pol2qm74 204 16 is be VBZ cord-015021-pol2qm74 204 17 rare rare JJ cord-015021-pol2qm74 204 18 . . . cord-015021-pol2qm74 205 1 In in IN cord-015021-pol2qm74 205 2 contrast contrast NN cord-015021-pol2qm74 205 3 , , , cord-015021-pol2qm74 205 4 experimental experimental JJ cord-015021-pol2qm74 205 5 evidence evidence NN cord-015021-pol2qm74 205 6 is be VBZ cord-015021-pol2qm74 205 7 accumulating accumulate VBG cord-015021-pol2qm74 205 8 for for IN cord-015021-pol2qm74 205 9 a a DT cord-015021-pol2qm74 205 10 role role NN cord-015021-pol2qm74 205 11 of of IN cord-015021-pol2qm74 205 12 membrane membrane NN cord-015021-pol2qm74 205 13 < < XX cord-015021-pol2qm74 205 14 lamaging lamage VBG cord-015021-pol2qm74 205 15 toxins toxin NNS cord-015021-pol2qm74 205 16 in in IN cord-015021-pol2qm74 205 17 the the DT cord-015021-pol2qm74 205 18 pathogenesis pathogenesis NN cord-015021-pol2qm74 205 19 of of IN cord-015021-pol2qm74 205 20 inflammatory inflammatory JJ cord-015021-pol2qm74 205 21 lesions lesion NNS cord-015021-pol2qm74 205 22 . . . cord-015021-pol2qm74 206 1 Formation formation NN cord-015021-pol2qm74 206 2 of of IN cord-015021-pol2qm74 206 3 transmembrane transmembrane NN cord-015021-pol2qm74 206 4 pores pore NNS cord-015021-pol2qm74 206 5 is be VBZ cord-015021-pol2qm74 206 6 probably probably RB cord-015021-pol2qm74 206 7 the the DT cord-015021-pol2qm74 206 8 most most RBS cord-015021-pol2qm74 206 9 widespread widespread JJ cord-015021-pol2qm74 206 10 mechanism mechanism NN cord-015021-pol2qm74 206 11 via via IN cord-015021-pol2qm74 206 12 which which WDT cord-015021-pol2qm74 206 13 such such JJ cord-015021-pol2qm74 206 14 physical physical JJ cord-015021-pol2qm74 206 15 membrane membrane NN cord-015021-pol2qm74 206 16 perturbation perturbation NN cord-015021-pol2qm74 206 17 can can MD cord-015021-pol2qm74 206 18 occur occur VB cord-015021-pol2qm74 206 19 ( ( -LRB- cord-015021-pol2qm74 206 20 1,2 1,2 CD cord-015021-pol2qm74 206 21 ) ) -RRB- cord-015021-pol2qm74 206 22 , , , cord-015021-pol2qm74 206 23 the the DT cord-015021-pol2qm74 206 24 present present JJ cord-015021-pol2qm74 206 25 discussion discussion NN cord-015021-pol2qm74 206 26 will will MD cord-015021-pol2qm74 206 27 be be VB cord-015021-pol2qm74 206 28 restricted restrict VBN cord-015021-pol2qm74 206 29 to to IN cord-015021-pol2qm74 206 30 this this DT cord-015021-pol2qm74 206 31 category category NN cord-015021-pol2qm74 206 32 of of IN cord-015021-pol2qm74 206 33 toxins toxin NNS cord-015021-pol2qm74 206 34 . . . cord-015021-pol2qm74 207 1 The the DT cord-015021-pol2qm74 207 2 author author NN cord-015021-pol2qm74 207 3 shall shall MD cord-015021-pol2qm74 207 4 first first RB cord-015021-pol2qm74 207 5 discuss discuss VB cord-015021-pol2qm74 207 6 basic basic JJ cord-015021-pol2qm74 207 7 properties property NNS cord-015021-pol2qm74 207 8 of of IN cord-015021-pol2qm74 207 9 pore pore NN cord-015021-pol2qm74 207 10 - - HYPH cord-015021-pol2qm74 207 11 forming form VBG cord-015021-pol2qm74 207 12 proteins protein NNS cord-015021-pol2qm74 207 13 , , , cord-015021-pol2qm74 207 14 and and CC cord-015021-pol2qm74 207 15 consider consider VB cord-015021-pol2qm74 207 16 the the DT cord-015021-pol2qm74 207 17 factors factor NNS cord-015021-pol2qm74 207 18 that that WDT cord-015021-pol2qm74 207 19 direct direct VBP cord-015021-pol2qm74 207 20 their -PRON- PRP$ cord-015021-pol2qm74 207 21 attack attack NN cord-015021-pol2qm74 207 22 to to IN cord-015021-pol2qm74 207 23 specific specific JJ cord-015021-pol2qm74 207 24 targets target NNS cord-015021-pol2qm74 207 25 . . . cord-015021-pol2qm74 208 1 Thereafter thereafter RB cord-015021-pol2qm74 208 2 , , , cord-015021-pol2qm74 208 3 attention attention NN cord-015021-pol2qm74 208 4 will will MD cord-015021-pol2qm74 208 5 be be VB cord-015021-pol2qm74 208 6 drawn draw VBN cord-015021-pol2qm74 208 7 to to IN cord-015021-pol2qm74 208 8 diverse diverse JJ cord-015021-pol2qm74 208 9 functional functional JJ cord-015021-pol2qm74 208 10 consequences consequence NNS cord-015021-pol2qm74 208 11 that that WDT cord-015021-pol2qm74 208 12 may may MD cord-015021-pol2qm74 208 13 follow follow VB cord-015021-pol2qm74 208 14 membrane membrane NN cord-015021-pol2qm74 208 15 damage damage NN cord-015021-pol2qm74 208 16 so so IN cord-015021-pol2qm74 208 17 that that IN cord-015021-pol2qm74 208 18 a a DT cord-015021-pol2qm74 208 19 general general JJ cord-015021-pol2qm74 208 20 concept concept NN cord-015021-pol2qm74 208 21 of of IN cord-015021-pol2qm74 208 22 how how WRB cord-015021-pol2qm74 208 23 pore pore NN cord-015021-pol2qm74 208 24 - - HYPH cord-015021-pol2qm74 208 25 forming form VBG cord-015021-pol2qm74 208 26 toxins toxin NNS cord-015021-pol2qm74 208 27 may may MD cord-015021-pol2qm74 208 28 contribute contribute VB cord-015021-pol2qm74 208 29 towards towards IN cord-015021-pol2qm74 208 30 the the DT cord-015021-pol2qm74 208 31 development development NN cord-015021-pol2qm74 208 32 of of IN cord-015021-pol2qm74 208 33 shock shock NN cord-015021-pol2qm74 208 34 will will MD cord-015021-pol2qm74 208 35 evolve evolve VB cord-015021-pol2qm74 208 36 . . . cord-015021-pol2qm74 209 1 I. I. NNP cord-015021-pol2qm74 209 2 Bhakdi Bhakdi NNP cord-015021-pol2qm74 209 3 , , , cord-015021-pol2qm74 209 4 S. S. NNP cord-015021-pol2qm74 209 5 and and CC cord-015021-pol2qm74 209 6 Tranum Tranum NNP cord-015021-pol2qm74 209 7 - - HYPH cord-015021-pol2qm74 209 8 Jensen Jensen NNP cord-015021-pol2qm74 209 9 . . . cord-015021-pol2qm74 210 1 J. J. NNP cord-015021-pol2qm74 210 2 1987 1987 CD cord-015021-pol2qm74 211 1 Gram gram NN cord-015021-pol2qm74 211 2 positive positive JJ cord-015021-pol2qm74 211 3 bacteria bacteria NNS cord-015021-pol2qm74 211 4 produce produce VBP cord-015021-pol2qm74 211 5 exotoxins exotoxin NNS cord-015021-pol2qm74 211 6 that that IN cord-015021-pol2qm74 211 7 , , , cord-015021-pol2qm74 211 8 at at IN cord-015021-pol2qm74 211 9 least least JJS cord-015021-pol2qm74 211 10 in in IN cord-015021-pol2qm74 211 11 part part NN cord-015021-pol2qm74 211 12 , , , cord-015021-pol2qm74 211 13 exhibit exhibit VB cord-015021-pol2qm74 211 14 the the DT cord-015021-pol2qm74 211 15 unusual unusual JJ cord-015021-pol2qm74 211 16 properties property NNS cord-015021-pol2qm74 211 17 of of IN cord-015021-pol2qm74 211 18 superantigens superantigen NNS cord-015021-pol2qm74 211 19 . . . cord-015021-pol2qm74 212 1 Superantigens Superantigens NNP cord-015021-pol2qm74 212 2 ( ( -LRB- cord-015021-pol2qm74 212 3 SAg SAg NNS cord-015021-pol2qm74 212 4 ) ) -RRB- cord-015021-pol2qm74 212 5 activate activate VBP cord-015021-pol2qm74 212 6 V/3 V/3 NNP cord-015021-pol2qm74 212 7 selectively selectively RB cord-015021-pol2qm74 212 8 T t NN cord-015021-pol2qm74 212 9 cells cell NNS cord-015021-pol2qm74 212 10 to to TO cord-015021-pol2qm74 212 11 produce produce VB cord-015021-pol2qm74 212 12 lymphokines lymphokine NNS cord-015021-pol2qm74 212 13 including include VBG cord-015021-pol2qm74 212 14 I1 i1 NN cord-015021-pol2qm74 212 15 - - HYPH cord-015021-pol2qm74 212 16 2 2 NNP cord-015021-pol2qm74 212 17 and and CC cord-015021-pol2qm74 212 18 TNF TNF NNP cord-015021-pol2qm74 212 19 / / SYM cord-015021-pol2qm74 212 20 lymphotoxin lymphotoxin NNP cord-015021-pol2qm74 212 21 . . . cord-015021-pol2qm74 213 1 Systemic systemic JJ cord-015021-pol2qm74 213 2 application application NN cord-015021-pol2qm74 213 3 of of IN cord-015021-pol2qm74 213 4 the the DT cord-015021-pol2qm74 213 5 SAg SAg NNS cord-015021-pol2qm74 213 6 staphylococcal staphylococcal JJ cord-015021-pol2qm74 213 7 enterotoxin enterotoxin NNP cord-015021-pol2qm74 213 8 B B NNP cord-015021-pol2qm74 213 9 ( ( -LRB- cord-015021-pol2qm74 213 10 SEB SEB NNP cord-015021-pol2qm74 213 11 ) ) -RRB- cord-015021-pol2qm74 213 12 to to IN cord-015021-pol2qm74 213 13 D D NNP cord-015021-pol2qm74 213 14 - - HYPH cord-015021-pol2qm74 213 15 galactosamine galactosamine NN cord-015021-pol2qm74 213 16 sensitized sensitize VBN cord-015021-pol2qm74 213 17 mice mouse NNS cord-015021-pol2qm74 213 18 causes cause VBZ cord-015021-pol2qm74 213 19 lethal lethal JJ cord-015021-pol2qm74 213 20 shock shock NN cord-015021-pol2qm74 213 21 within within IN cord-015021-pol2qm74 213 22 hours hour NNS cord-015021-pol2qm74 213 23 . . . cord-015021-pol2qm74 214 1 SEB SEB NNP cord-015021-pol2qm74 214 2 reactive reactive JJ cord-015021-pol2qm74 215 1 V/38 V/38 NNP cord-015021-pol2qm74 215 2 + + CC cord-015021-pol2qm74 215 3 T t NN cord-015021-pol2qm74 215 4 cells cell NNS cord-015021-pol2qm74 215 5 accumulate accumulate VBP cord-015021-pol2qm74 215 6 within within IN cord-015021-pol2qm74 215 7 90 90 CD cord-015021-pol2qm74 215 8 - - SYM cord-015021-pol2qm74 215 9 120 120 CD cord-015021-pol2qm74 215 10 min min NN cord-015021-pol2qm74 215 11 mRNA mrna NN cord-015021-pol2qm74 215 12 for for IN cord-015021-pol2qm74 215 13 the the DT cord-015021-pol2qm74 215 14 II-2 II-2 NNP cord-015021-pol2qm74 215 15 , , , cord-015021-pol2qm74 215 16 I1 i1 NN cord-015021-pol2qm74 215 17 - - HYPH cord-015021-pol2qm74 215 18 4 4 CD cord-015021-pol2qm74 215 19 , , , cord-015021-pol2qm74 215 20 TNFaI~ TNFaI~ NNP cord-015021-pol2qm74 215 21 and and CC cord-015021-pol2qm74 215 22 IFN-3 IFN-3 NNP cord-015021-pol2qm74 215 23 , , , cord-015021-pol2qm74 215 24 . . . cord-015021-pol2qm74 216 1 Parallel parallel JJ cord-015021-pol2qm74 216 2 in in IN cord-015021-pol2qm74 216 3 time time NN cord-015021-pol2qm74 216 4 high high JJ cord-015021-pol2qm74 216 5 concentrations concentration NNS cord-015021-pol2qm74 216 6 of of IN cord-015021-pol2qm74 216 7 bloodborne bloodborne JJ cord-015021-pol2qm74 216 8 I1 i1 NN cord-015021-pol2qm74 216 9 - - HYPH cord-015021-pol2qm74 216 10 2 2 NNP cord-015021-pol2qm74 216 11 and and CC cord-015021-pol2qm74 216 12 TNF TNF NNP cord-015021-pol2qm74 216 13 are be VBP cord-015021-pol2qm74 216 14 noted note VBN cord-015021-pol2qm74 216 15 . . . cord-015021-pol2qm74 217 1 Anti Anti NNP cord-015021-pol2qm74 217 2 TNF TNF NNP cord-015021-pol2qm74 217 3 t~//3 t~//3 IN cord-015021-pol2qm74 217 4 neutralizing neutralize VBG cord-015021-pol2qm74 217 5 mAb mab JJ cord-015021-pol2qm74 217 6 protect protect JJ cord-015021-pol2qm74 217 7 mice mouse NNS cord-015021-pol2qm74 217 8 against against IN cord-015021-pol2qm74 217 9 SEB SEB NNP cord-015021-pol2qm74 217 10 induced induce VBD cord-015021-pol2qm74 217 11 T T NNP cord-015021-pol2qm74 217 12 cell cell NN cord-015021-pol2qm74 217 13 dependent dependent JJ cord-015021-pol2qm74 217 14 lethal lethal JJ cord-015021-pol2qm74 217 15 shock shock NN cord-015021-pol2qm74 217 16 thus thus RB cord-015021-pol2qm74 217 17 indicating indicate VBG cord-015021-pol2qm74 217 18 a a DT cord-015021-pol2qm74 217 19 key key JJ cord-015021-pol2qm74 217 20 role role NN cord-015021-pol2qm74 217 21 of of IN cord-015021-pol2qm74 217 22 TNF TNF NNP cord-015021-pol2qm74 217 23 in in IN cord-015021-pol2qm74 217 24 effecting effect VBG cord-015021-pol2qm74 217 25 lethal lethal JJ cord-015021-pol2qm74 217 26 toxicity toxicity NN cord-015021-pol2qm74 217 27 . . . cord-015021-pol2qm74 218 1 Within within IN cord-015021-pol2qm74 218 2 12 12 CD cord-015021-pol2qm74 218 3 - - SYM cord-015021-pol2qm74 218 4 18 18 CD cord-015021-pol2qm74 218 5 h h NN cord-015021-pol2qm74 218 6 distinct distinct JJ cord-015021-pol2qm74 218 7 levels level NNS cord-015021-pol2qm74 218 8 of of IN cord-015021-pol2qm74 218 9 tolerance tolerance NN cord-015021-pol2qm74 218 10 to to IN cord-015021-pol2qm74 218 11 SEB SEB NNP cord-015021-pol2qm74 218 12 become become VBP cord-015021-pol2qm74 218 13 discernable discernable JJ cord-015021-pol2qm74 218 14 on on IN cord-015021-pol2qm74 218 15 ligand ligand NN cord-015021-pol2qm74 218 16 reactive reactive JJ cord-015021-pol2qm74 218 17 V/38 V/38 NNP cord-015021-pol2qm74 218 18 T T NNP cord-015021-pol2qm74 218 19 ceils ceil NNS cord-015021-pol2qm74 218 20 , , , cord-015021-pol2qm74 218 21 dependent dependent JJ cord-015021-pol2qm74 218 22 of of IN cord-015021-pol2qm74 218 23 the the DT cord-015021-pol2qm74 218 24 dose dose NN cord-015021-pol2qm74 218 25 of of IN cord-015021-pol2qm74 218 26 SEB SEB NNP cord-015021-pol2qm74 218 27 used use VBD cord-015021-pol2qm74 218 28 . . . cord-015021-pol2qm74 219 1 These these DT cord-015021-pol2qm74 219 2 levels level NNS cord-015021-pol2qm74 219 3 include include VBP cord-015021-pol2qm74 219 4 anergy anergy NNP cord-015021-pol2qm74 219 5 , , , cord-015021-pol2qm74 219 6 T T NNP cord-015021-pol2qm74 219 7 cell cell NN cord-015021-pol2qm74 219 8 receptor receptor NN cord-015021-pol2qm74 219 9 downregulation downregulation NN cord-015021-pol2qm74 219 10 , , , cord-015021-pol2qm74 219 11 loss loss NN cord-015021-pol2qm74 219 12 of of IN cord-015021-pol2qm74 219 13 CD2 CD2 NNP cord-015021-pol2qm74 219 14 , , , cord-015021-pol2qm74 219 15 CD4 CD4 NNP cord-015021-pol2qm74 219 16 , , , cord-015021-pol2qm74 219 17 CD8 CD8 NNP cord-015021-pol2qm74 219 18 accessory accessory NN cord-015021-pol2qm74 219 19 molecules molecule NNS cord-015021-pol2qm74 219 20 and and CC cord-015021-pol2qm74 219 21 programmed program VBD cord-015021-pol2qm74 219 22 cell cell NN cord-015021-pol2qm74 219 23 death death NN cord-015021-pol2qm74 219 24 . . . cord-015021-pol2qm74 220 1 M.Freudenberg M.Freudenberg NNP cord-015021-pol2qm74 220 2 , , , cord-015021-pol2qm74 220 3 Y.Yaegashi Y.Yaegashi NNP cord-015021-pol2qm74 220 4 , , , cord-015021-pol2qm74 220 5 P.Nielsen P.Nielsen NNP cord-015021-pol2qm74 220 6 , , , cord-015021-pol2qm74 220 7 C.Galanos C.Galanos NNP cord-015021-pol2qm74 220 8 . . . cord-015021-pol2qm74 221 1 The the DT cord-015021-pol2qm74 221 2 sensitivity sensitivity NN cord-015021-pol2qm74 221 3 towards towards IN cord-015021-pol2qm74 221 4 endotoxin endotoxin NN cord-015021-pol2qm74 221 5 ( ( -LRB- cord-015021-pol2qm74 221 6 LPS LPS NNP cord-015021-pol2qm74 221 7 ) ) -RRB- cord-015021-pol2qm74 221 8 is be VBZ cord-015021-pol2qm74 221 9 genetically genetically RB cord-015021-pol2qm74 221 10 determined determine VBN cord-015021-pol2qm74 221 11 , , , cord-015021-pol2qm74 221 12 however however RB cord-015021-pol2qm74 221 13 it -PRON- PRP cord-015021-pol2qm74 221 14 may may MD cord-015021-pol2qm74 221 15 be be VB cord-015021-pol2qm74 221 16 increased increase VBN cord-015021-pol2qm74 221 17 under under IN cord-015021-pol2qm74 221 18 different different JJ cord-015021-pol2qm74 221 19 experimental experimental JJ cord-015021-pol2qm74 221 20 conditions condition NNS cord-015021-pol2qm74 221 21 . . . cord-015021-pol2qm74 222 1 These these DT cord-015021-pol2qm74 222 2 include include VBP cord-015021-pol2qm74 222 3 treatment treatment NN cord-015021-pol2qm74 222 4 with with IN cord-015021-pol2qm74 222 5 hepatotoxic hepatotoxic JJ cord-015021-pol2qm74 222 6 agents agent NNS cord-015021-pol2qm74 222 7 such such JJ cord-015021-pol2qm74 222 8 as as IN cord-015021-pol2qm74 222 9 D d NN cord-015021-pol2qm74 222 10 - - HYPH cord-015021-pol2qm74 222 11 galactosamine galactosamine NN cord-015021-pol2qm74 222 12 , , , cord-015021-pol2qm74 222 13 and and CC cord-015021-pol2qm74 222 14 with with IN cord-015021-pol2qm74 222 15 live live JJ cord-015021-pol2qm74 222 16 ( ( -LRB- cord-015021-pol2qm74 222 17 infection infection NN cord-015021-pol2qm74 222 18 ) ) -RRB- cord-015021-pol2qm74 222 19 or or CC cord-015021-pol2qm74 222 20 killed kill VBD cord-015021-pol2qm74 222 21 bacteria bacteria NNS cord-015021-pol2qm74 222 22 . . . cord-015021-pol2qm74 223 1 It -PRON- PRP cord-015021-pol2qm74 223 2 is be VBZ cord-015021-pol2qm74 223 3 well well RB cord-015021-pol2qm74 223 4 established establish VBN cord-015021-pol2qm74 223 5 now now RB cord-015021-pol2qm74 223 6 that that IN cord-015021-pol2qm74 223 7 D d NN cord-015021-pol2qm74 223 8 - - HYPH cord-015021-pol2qm74 223 9 galactosamine galactosamine NN cord-015021-pol2qm74 223 10 sensitizes sensitize VBZ cord-015021-pol2qm74 223 11 to to IN cord-015021-pol2qm74 223 12 LPS LPS NNP cord-015021-pol2qm74 223 13 by by IN cord-015021-pol2qm74 223 14 increasing increase VBG cord-015021-pol2qm74 223 15 the the DT cord-015021-pol2qm74 223 16 susceptibility susceptibility NN cord-015021-pol2qm74 223 17 of of IN cord-015021-pol2qm74 223 18 the the DT cord-015021-pol2qm74 223 19 host host NN cord-015021-pol2qm74 223 20 to to IN cord-015021-pol2qm74 223 21 toxic toxic JJ cord-015021-pol2qm74 223 22 activity activity NN cord-015021-pol2qm74 223 23 of of IN cord-015021-pol2qm74 223 24 LPS LPS NNP cord-015021-pol2qm74 223 25 - - HYPH cord-015021-pol2qm74 223 26 induced induce VBN cord-015021-pol2qm74 223 27 TNF~. TNF~. NNP cord-015021-pol2qm74 223 28 Sensitization sensitization NN cord-015021-pol2qm74 223 29 by by IN cord-015021-pol2qm74 223 30 bacteria bacteria NNS cord-015021-pol2qm74 223 31 , , , cord-015021-pol2qm74 223 32 especially especially RB cord-015021-pol2qm74 223 33 by by IN cord-015021-pol2qm74 223 34 Gram gram NN cord-015021-pol2qm74 223 35 - - HYPH cord-015021-pol2qm74 223 36 negative negative JJ cord-015021-pol2qm74 223 37 once once RB cord-015021-pol2qm74 223 38 is be VBZ cord-015021-pol2qm74 223 39 of of IN cord-015021-pol2qm74 223 40 especial especial JJ cord-015021-pol2qm74 223 41 interest interest NN cord-015021-pol2qm74 223 42 because because IN cord-015021-pol2qm74 223 43 it -PRON- PRP cord-015021-pol2qm74 223 44 implies imply VBZ cord-015021-pol2qm74 223 45 that that IN cord-015021-pol2qm74 223 46 infecting infect VBG cord-015021-pol2qm74 223 47 microorganisms microorganism NNS cord-015021-pol2qm74 223 48 not not RB cord-015021-pol2qm74 223 49 only only RB cord-015021-pol2qm74 223 50 produce produce VBP cord-015021-pol2qm74 223 51 LPS lp NNS cord-015021-pol2qm74 223 52 , , , cord-015021-pol2qm74 223 53 but but CC cord-015021-pol2qm74 223 54 als0 als0 TO cord-015021-pol2qm74 223 55 sensitize sensitize VB cord-015021-pol2qm74 223 56 the the DT cord-015021-pol2qm74 223 57 host host NN cord-015021-pol2qm74 223 58 to to IN cord-015021-pol2qm74 223 59 its -PRON- PRP$ cord-015021-pol2qm74 223 60 lethal lethal JJ cord-015021-pol2qm74 223 61 activity activity NN cord-015021-pol2qm74 223 62 . . . cord-015021-pol2qm74 224 1 Sensitization sensitization NN cord-015021-pol2qm74 224 2 to to IN cord-015021-pol2qm74 224 3 LPS LPS NNP cord-015021-pol2qm74 224 4 by by IN cord-015021-pol2qm74 224 5 bacteria bacteria NNS cord-015021-pol2qm74 224 6 proceeds proceed NNS cord-015021-pol2qm74 224 7 in in IN cord-015021-pol2qm74 224 8 all all DT cord-015021-pol2qm74 224 9 LPS LPS NNP cord-015021-pol2qm74 224 10 - - HYPH cord-015021-pol2qm74 224 11 sensitive sensitive JJ cord-015021-pol2qm74 224 12 ( ( -LRB- cord-015021-pol2qm74 224 13 Lps Lps NNP cord-015021-pol2qm74 224 14 n n NNP cord-015021-pol2qm74 224 15 ) ) -RRB- cord-015021-pol2qm74 224 16 mouse mouse NN cord-015021-pol2qm74 224 17 strains strain NNS cord-015021-pol2qm74 224 18 that that WDT cord-015021-pol2qm74 224 19 have have VBP cord-015021-pol2qm74 224 20 been be VBN cord-015021-pol2qm74 224 21 investigated investigate VBN cord-015021-pol2qm74 224 22 so so RB cord-015021-pol2qm74 224 23 far far RB cord-015021-pol2qm74 224 24 . . . cord-015021-pol2qm74 225 1 It -PRON- PRP cord-015021-pol2qm74 225 2 also also RB cord-015021-pol2qm74 225 3 proceeds proceed VBZ cord-015021-pol2qm74 225 4 in in IN cord-015021-pol2qm74 225 5 LPS lps NN cord-015021-pol2qm74 225 6 - - HYPH cord-015021-pol2qm74 225 7 resistant resistant JJ cord-015021-pol2qm74 225 8 ( ( -LRB- cord-015021-pol2qm74 225 9 Lps Lps NNP cord-015021-pol2qm74 225 10 d d NN cord-015021-pol2qm74 225 11 ) ) -RRB- cord-015021-pol2qm74 226 1 C3H C3H NNP cord-015021-pol2qm74 226 2 / / SYM cord-015021-pol2qm74 226 3 HeJ HeJ NNP cord-015021-pol2qm74 226 4 mice mouse NNS cord-015021-pol2qm74 226 5 . . . cord-015021-pol2qm74 227 1 The the DT cord-015021-pol2qm74 227 2 absence absence NN cord-015021-pol2qm74 227 3 of of IN cord-015021-pol2qm74 227 4 sensitization sensitization NN cord-015021-pol2qm74 227 5 to to IN cord-015021-pol2qm74 227 6 LPS LPS NNP cord-015021-pol2qm74 227 7 in in IN cord-015021-pol2qm74 227 8 Lps Lps NNP cord-015021-pol2qm74 227 9 d d NNP cord-015021-pol2qm74 227 10 C57BL/10ScCr C57BL/10ScCr NNP cord-015021-pol2qm74 227 11 mice mouse NNS cord-015021-pol2qm74 227 12 was be VBD cord-015021-pol2qm74 227 13 identified identify VBN cord-015021-pol2qm74 227 14 as as IN cord-015021-pol2qm74 227 15 being be VBG cord-015021-pol2qm74 227 16 due due JJ cord-015021-pol2qm74 227 17 to to IN cord-015021-pol2qm74 227 18 their -PRON- PRP$ cord-015021-pol2qm74 227 19 inability inability NN cord-015021-pol2qm74 227 20 to to TO cord-015021-pol2qm74 227 21 produce produce VB cord-015021-pol2qm74 227 22 interferon-7 interferon-7 PRP cord-015021-pol2qm74 227 23 ( ( -LRB- cord-015021-pol2qm74 227 24 IFN IFN NNP cord-015021-pol2qm74 227 25 ? ? . cord-015021-pol2qm74 227 26 ) ) -RRB- cord-015021-pol2qm74 227 27 . . . cord-015021-pol2qm74 228 1 Administration administration NN cord-015021-pol2qm74 228 2 of of IN cord-015021-pol2qm74 228 3 exogenous exogenous JJ cord-015021-pol2qm74 228 4 IFN IFN NNP cord-015021-pol2qm74 228 5 ? ? . cord-015021-pol2qm74 229 1 to to IN cord-015021-pol2qm74 229 2 these these DT cord-015021-pol2qm74 229 3 mice mouse NNS cord-015021-pol2qm74 229 4 conferred confer VBD cord-015021-pol2qm74 229 5 sensitivity sensitivity NN cord-015021-pol2qm74 229 6 to to IN cord-015021-pol2qm74 229 7 LPS lp NNS cord-015021-pol2qm74 229 8 . . . cord-015021-pol2qm74 230 1 Conversely conversely RB cord-015021-pol2qm74 230 2 , , , cord-015021-pol2qm74 230 3 administration administration NN cord-015021-pol2qm74 230 4 of of IN cord-015021-pol2qm74 230 5 anti anti NNP cord-015021-pol2qm74 230 6 - - NNP cord-015021-pol2qm74 230 7 IFN IFN NNP cord-015021-pol2qm74 230 8 ? ? . cord-015021-pol2qm74 231 1 to to IN cord-015021-pol2qm74 231 2 Lpsn Lpsn NNP cord-015021-pol2qm74 231 3 ; ; : cord-015021-pol2qm74 231 4 mice mouse NNS cord-015021-pol2qm74 231 5 inhibited inhibit VBD cord-015021-pol2qm74 231 6 the the DT cord-015021-pol2qm74 231 7 development development NN cord-015021-pol2qm74 231 8 of of IN cord-015021-pol2qm74 231 9 sensitization'by sensitization'by NN cord-015021-pol2qm74 231 10 bacteria bacteria NNS cord-015021-pol2qm74 231 11 . . . cord-015021-pol2qm74 232 1 It -PRON- PRP cord-015021-pol2qm74 232 2 may may MD cord-015021-pol2qm74 232 3 be be VB cord-015021-pol2qm74 232 4 concluded conclude VBN cord-015021-pol2qm74 232 5 therefore therefore RB cord-015021-pol2qm74 232 6 that that IN cord-015021-pol2qm74 232 7 IFN7 IFN7 NNP cord-015021-pol2qm74 232 8 is be VBZ cord-015021-pol2qm74 232 9 the the DT cord-015021-pol2qm74 232 10 mediator mediator NN cord-015021-pol2qm74 232 11 of of IN cord-015021-pol2qm74 232 12 sensitization sensitization NN cord-015021-pol2qm74 232 13 to to IN cord-015021-pol2qm74 232 14 LPS lp NNS cord-015021-pol2qm74 232 15 by by IN cord-015021-pol2qm74 232 16 bacterial bacterial JJ cord-015021-pol2qm74 232 17 infection infection NN cord-015021-pol2qm74 232 18 . . . cord-015021-pol2qm74 233 1 The the DT cord-015021-pol2qm74 233 2 IFN IFN NNP cord-015021-pol2qm74 233 3 ? ? . cord-015021-pol2qm74 234 1 defect defect NN cord-015021-pol2qm74 234 2 of of IN cord-015021-pol2qm74 234 3 C57BL/10ScCr c57bl/10sccr JJ cord-015021-pol2qm74 234 4 mice mouse NNS cord-015021-pol2qm74 234 5 concerns concern VBZ cord-015021-pol2qm74 234 6 only only RB cord-015021-pol2qm74 234 7 the the DT cord-015021-pol2qm74 234 8 IFN7 IFN7 NNP cord-015021-pol2qm74 234 9 response response NN cord-015021-pol2qm74 234 10 to to IN cord-015021-pol2qm74 234 11 bacteria bacteria NNS cord-015021-pol2qm74 234 12 , , , cord-015021-pol2qm74 234 13 since since IN cord-015021-pol2qm74 234 14 the the DT cord-015021-pol2qm74 234 15 response response NN cord-015021-pol2qm74 234 16 to to IN cord-015021-pol2qm74 234 17 the the DT cord-015021-pol2qm74 234 18 T t NN cord-015021-pol2qm74 234 19 - - HYPH cord-015021-pol2qm74 234 20 cell cell NN cord-015021-pol2qm74 234 21 mitogen mitogen NNP cord-015021-pol2qm74 234 22 Con Con NNP cord-015021-pol2qm74 234 23 A A NNP cord-015021-pol2qm74 234 24 and and CC cord-015021-pol2qm74 234 25 to to IN cord-015021-pol2qm74 234 26 CD3 CD3 NNP cord-015021-pol2qm74 234 27 monoclonal monoclonal JJ cord-015021-pol2qm74 234 28 antibodies antibody NNS cord-015021-pol2qm74 234 29 was be VBD cord-015021-pol2qm74 234 30 not not RB cord-015021-pol2qm74 234 31 impaired impaired JJ cord-015021-pol2qm74 234 32 . . . cord-015021-pol2qm74 235 1 The the DT cord-015021-pol2qm74 235 2 IFN?producing ifn?producing NN cord-015021-pol2qm74 235 3 cells cell NNS cord-015021-pol2qm74 235 4 themselves -PRON- PRP cord-015021-pol2qm74 235 5 were be VBD cord-015021-pol2qm74 235 6 shown show VBN cord-015021-pol2qm74 235 7 to to TO cord-015021-pol2qm74 235 8 be be VB cord-015021-pol2qm74 235 9 intact intact JJ cord-015021-pol2qm74 235 10 . . . cord-015021-pol2qm74 236 1 On on IN cord-015021-pol2qm74 236 2 closer close JJR cord-015021-pol2qm74 236 3 investigation investigation NN cord-015021-pol2qm74 236 4 the the DT cord-015021-pol2qm74 236 5 impaired impaired JJ cord-015021-pol2qm74 236 6 IFN IFN NNP cord-015021-pol2qm74 236 7 ? ? . cord-015021-pol2qm74 237 1 response response NN cord-015021-pol2qm74 237 2 was be VBD cord-015021-pol2qm74 237 3 identified identify VBN cord-015021-pol2qm74 237 4 as as IN cord-015021-pol2qm74 237 5 the the DT cord-015021-pol2qm74 237 6 result result NN cord-015021-pol2qm74 237 7 of of IN cord-015021-pol2qm74 237 8 a a DT cord-015021-pol2qm74 237 9 defective defective JJ cord-015021-pol2qm74 237 10 accessory accessory NN cord-015021-pol2qm74 237 11 function function NN cord-015021-pol2qm74 237 12 of of IN cord-015021-pol2qm74 237 13 macrophages macrophage NNS cord-015021-pol2qm74 237 14 . . . cord-015021-pol2qm74 238 1 Macrophages macrophage NNS cord-015021-pol2qm74 238 2 of of IN cord-015021-pol2qm74 238 3 C57BL/10ScCr c57bl/10sccr JJ cord-015021-pol2qm74 238 4 mice mouse NNS cord-015021-pol2qm74 238 5 are be VBP cord-015021-pol2qm74 238 6 incapable incapable JJ cord-015021-pol2qm74 238 7 of of IN cord-015021-pol2qm74 238 8 producing produce VBG cord-015021-pol2qm74 238 9 interferon-~ interferon-~ NNP cord-015021-pol2qm74 238 10 ( ( -LRB- cord-015021-pol2qm74 238 11 IFN~ ifn~ NN cord-015021-pol2qm74 238 12 ) ) -RRB- cord-015021-pol2qm74 238 13 which which WDT cord-015021-pol2qm74 238 14 we -PRON- PRP cord-015021-pol2qm74 238 15 could could MD cord-015021-pol2qm74 238 16 show show VB cord-015021-pol2qm74 238 17 to to TO cord-015021-pol2qm74 238 18 be be VB cord-015021-pol2qm74 238 19 obligatory obligatory JJ cord-015021-pol2qm74 238 20 for for IN cord-015021-pol2qm74 238 21 the the DT cord-015021-pol2qm74 238 22 production production NN cord-015021-pol2qm74 238 23 of of IN cord-015021-pol2qm74 238 24 IFN IFN NNP cord-015021-pol2qm74 238 25 ? ? . cord-015021-pol2qm74 239 1 in in IN cord-015021-pol2qm74 239 2 response response NN cord-015021-pol2qm74 239 3 to to IN cord-015021-pol2qm74 239 4 bacteria bacteria NNS cord-015021-pol2qm74 239 5 . . . cord-015021-pol2qm74 240 1 Although although IN cord-015021-pol2qm74 240 2 antibiotics antibiotic NNS cord-015021-pol2qm74 240 3 are be VBP cord-015021-pol2qm74 240 4 required require VBN cord-015021-pol2qm74 240 5 to to TO cord-015021-pol2qm74 240 6 clear clear VB cord-015021-pol2qm74 240 7 bacteremia bacteremia NN cord-015021-pol2qm74 240 8 , , , cord-015021-pol2qm74 240 9 they -PRON- PRP cord-015021-pol2qm74 240 10 do do VBP cord-015021-pol2qm74 240 11 not not RB cord-015021-pol2qm74 240 12 reverse reverse VB cord-015021-pol2qm74 240 13 evolving evolve VBG cord-015021-pol2qm74 240 14 shock shock NN cord-015021-pol2qm74 240 15 , , , cord-015021-pol2qm74 241 1 because because IN cord-015021-pol2qm74 241 2 endotoxin endotoxin NN cord-015021-pol2qm74 241 3 free free JJ cord-015021-pol2qm74 241 4 in in IN cord-015021-pol2qm74 241 5 the the DT cord-015021-pol2qm74 241 6 bloodstream bloodstream NN cord-015021-pol2qm74 241 7 or or CC cord-015021-pol2qm74 241 8 exposed expose VBN cord-015021-pol2qm74 241 9 on on IN cord-015021-pol2qm74 241 10 the the DT cord-015021-pol2qm74 241 11 surface surface NN cord-015021-pol2qm74 241 12 of of IN cord-015021-pol2qm74 241 13 circulating circulate VBG cord-015021-pol2qm74 241 14 bacteria bacteria NNS cord-015021-pol2qm74 241 15 continues continue VBZ cord-015021-pol2qm74 241 16 to to TO cord-015021-pol2qm74 241 17 activate activate VB cord-015021-pol2qm74 241 18 the the DT cord-015021-pol2qm74 241 19 production production NN cord-015021-pol2qm74 241 20 of of IN cord-015021-pol2qm74 241 21 inflammatory inflammatory JJ cord-015021-pol2qm74 241 22 mediators mediator NNS cord-015021-pol2qm74 241 23 , , , cord-015021-pol2qm74 241 24 Furthermore furthermore RB cord-015021-pol2qm74 241 25 , , , cord-015021-pol2qm74 241 26 antibiotics antibiotic NNS cord-015021-pol2qm74 241 27 have have VBP cord-015021-pol2qm74 241 28 been be VBN cord-015021-pol2qm74 241 29 shown show VBN cord-015021-pol2qm74 241 30 to to TO cord-015021-pol2qm74 241 31 induce induce VB cord-015021-pol2qm74 241 32 release release NN cord-015021-pol2qm74 241 33 of of IN cord-015021-pol2qm74 241 34 endotoxin endotoxin NN cord-015021-pol2qm74 241 35 from from IN cord-015021-pol2qm74 241 36 gram gram JJ cord-015021-pol2qm74 241 37 - - HYPH cord-015021-pol2qm74 241 38 negative negative JJ cord-015021-pol2qm74 241 39 bacteria bacteria NNS cord-015021-pol2qm74 241 40 during during IN cord-015021-pol2qm74 241 41 the the DT cord-015021-pol2qm74 241 42 treatment treatment NN cord-015021-pol2qm74 241 43 of of IN cord-015021-pol2qm74 241 44 severe severe JJ cord-015021-pol2qm74 241 45 infection infection NN cord-015021-pol2qm74 241 46 . . . cord-015021-pol2qm74 242 1 In in IN cord-015021-pol2qm74 242 2 an an DT cord-015021-pol2qm74 242 3 in in IN cord-015021-pol2qm74 242 4 - - HYPH cord-015021-pol2qm74 242 5 vitro vitro FW cord-015021-pol2qm74 242 6 study study NN cord-015021-pol2qm74 242 7 , , , cord-015021-pol2qm74 242 8 using use VBG cord-015021-pol2qm74 242 9 live live JJ cord-015021-pol2qm74 242 10 Escherichia Escherichia NNP cord-015021-pol2qm74 242 11 coil coil NN cord-015021-pol2qm74 242 12 , , , cord-015021-pol2qm74 242 13 we -PRON- PRP cord-015021-pol2qm74 242 14 have have VBP cord-015021-pol2qm74 242 15 observed observe VBN cord-015021-pol2qm74 242 16 the the DT cord-015021-pol2qm74 242 17 release release NN cord-015021-pol2qm74 242 18 of of IN cord-015021-pol2qm74 242 19 endotoxin endotoxin NN cord-015021-pol2qm74 242 20 upon upon IN cord-015021-pol2qm74 242 21 treatment treatment NN cord-015021-pol2qm74 242 22 with with IN cord-015021-pol2qm74 242 23 several several JJ cord-015021-pol2qm74 242 24 antibiotics antibiotic NNS cord-015021-pol2qm74 242 25 like like IN cord-015021-pol2qm74 242 26 cefuroxim cefuroxim NNS cord-015021-pol2qm74 242 27 , , , cord-015021-pol2qm74 242 28 imipenem imipenem NNP cord-015021-pol2qm74 242 29 , , , cord-015021-pol2qm74 242 30 ceftazidime ceftazidime NNP cord-015021-pol2qm74 242 31 and and CC cord-015021-pol2qm74 242 32 aztreonam aztreonam NNP cord-015021-pol2qm74 242 33 . . . cord-015021-pol2qm74 243 1 Incubation Incubation NNP cord-015021-pol2qm74 243 2 with with IN cord-015021-pol2qm74 243 3 imipenem imipenem NNP cord-015021-pol2qm74 243 4 or or CC cord-015021-pol2qm74 243 5 ceftazidime ceftazidime NNP cord-015021-pol2qm74 243 6 induced induce VBD cord-015021-pol2qm74 243 7 an an DT cord-015021-pol2qm74 243 8 early early JJ cord-015021-pol2qm74 243 9 lyeis lyeis NN cord-015021-pol2qm74 243 10 and and CC cord-015021-pol2qm74 243 11 a a DT cord-015021-pol2qm74 243 12 mild mild JJ cord-015021-pol2qm74 243 13 rise rise NN cord-015021-pol2qm74 243 14 in in IN cord-015021-pol2qm74 243 15 endotoxin endotoxin NN cord-015021-pol2qm74 243 16 levels level NNS cord-015021-pol2qm74 243 17 , , , cord-015021-pol2qm74 243 18 whereas whereas IN cord-015021-pol2qm74 243 19 incubation incubation NN cord-015021-pol2qm74 243 20 with with IN cord-015021-pol2qm74 243 21 cefuroxime cefuroxime NNP cord-015021-pol2qm74 243 22 or or CC cord-015021-pol2qm74 243 23 aztreonam aztreonam NNP cord-015021-pol2qm74 243 24 resulted result VBD cord-015021-pol2qm74 243 25 in in IN cord-015021-pol2qm74 243 26 the the DT cord-015021-pol2qm74 243 27 formation formation NN cord-015021-pol2qm74 243 28 of of IN cord-015021-pol2qm74 243 29 filaments filament NNS cord-015021-pol2qm74 243 30 with with IN cord-015021-pol2qm74 243 31 a a DT cord-015021-pol2qm74 243 32 late late JJ cord-015021-pol2qm74 243 33 but but CC cord-015021-pol2qm74 243 34 dramatic dramatic JJ cord-015021-pol2qm74 243 35 rise rise NN cord-015021-pol2qm74 243 36 in in IN cord-015021-pol2qm74 243 37 endotoxin endotoxin NN cord-015021-pol2qm74 243 38 levels level NNS cord-015021-pol2qm74 243 39 . . . cord-015021-pol2qm74 244 1 In in IN cord-015021-pol2qm74 244 2 a a DT cord-015021-pol2qm74 244 3 second second JJ cord-015021-pol2qm74 244 4 study study NN cord-015021-pol2qm74 244 5 we -PRON- PRP cord-015021-pol2qm74 244 6 studied study VBD cord-015021-pol2qm74 244 7 the the DT cord-015021-pol2qm74 244 8 influence influence NN cord-015021-pol2qm74 244 9 of of IN cord-015021-pol2qm74 244 10 different different JJ cord-015021-pol2qm74 244 11 antibiotics antibiotic NNS cord-015021-pol2qm74 244 12 on on IN cord-015021-pol2qm74 244 13 the the DT cord-015021-pol2qm74 244 14 TNF-= tnf-= CD cord-015021-pol2qm74 244 15 production production NN cord-015021-pol2qm74 244 16 of of IN cord-015021-pol2qm74 244 17 E.coli E.coli NNS cord-015021-pol2qm74 244 18 stimulated stimulate VBD cord-015021-pol2qm74 244 19 human human JJ cord-015021-pol2qm74 244 20 monocytes monocyte NNS cord-015021-pol2qm74 244 21 . . . cord-015021-pol2qm74 245 1 We -PRON- PRP cord-015021-pol2qm74 245 2 found find VBD cord-015021-pol2qm74 245 3 again again RB cord-015021-pol2qm74 245 4 great great JJ cord-015021-pol2qm74 245 5 differences difference NNS cord-015021-pol2qm74 245 6 in in IN cord-015021-pol2qm74 245 7 the the DT cord-015021-pol2qm74 245 8 production production NN cord-015021-pol2qm74 245 9 of of IN cord-015021-pol2qm74 245 10 this this DT cord-015021-pol2qm74 245 11 important important JJ cord-015021-pol2qm74 245 12 cytokine cytokine NN cord-015021-pol2qm74 245 13 among among IN cord-015021-pol2qm74 245 14 the the DT cord-015021-pol2qm74 245 15 different different JJ cord-015021-pol2qm74 245 16 antibiotics antibiotic NNS cord-015021-pol2qm74 245 17 according accord VBG cord-015021-pol2qm74 245 18 to to IN cord-015021-pol2qm74 245 19 their -PRON- PRP$ cord-015021-pol2qm74 245 20 capacity capacity NN cord-015021-pol2qm74 245 21 to to TO cord-015021-pol2qm74 245 22 induce induce VB cord-015021-pol2qm74 245 23 liberation liberation NN cord-015021-pol2qm74 245 24 of of IN cord-015021-pol2qm74 245 25 endotoxin endotoxin NN cord-015021-pol2qm74 245 26 . . . cord-015021-pol2qm74 246 1 These these DT cord-015021-pol2qm74 246 2 differences difference NNS cord-015021-pol2qm74 246 3 in in IN cord-015021-pol2qm74 246 4 the the DT cord-015021-pol2qm74 246 5 amount amount NN cord-015021-pol2qm74 246 6 of of IN cord-015021-pol2qm74 246 7 endotoxin endotoxin NN cord-015021-pol2qm74 246 8 release release NN cord-015021-pol2qm74 246 9 are be VBP cord-015021-pol2qm74 246 10 probably probably RB cord-015021-pol2qm74 246 11 caused cause VBN cord-015021-pol2qm74 246 12 by by IN cord-015021-pol2qm74 246 13 Penicillin Penicillin NNP cord-015021-pol2qm74 246 14 - - HYPH cord-015021-pol2qm74 246 15 Binding Binding NNP cord-015021-pol2qm74 246 16 - - HYPH cord-015021-pol2qm74 246 17 Proteins Proteins NNP cord-015021-pol2qm74 246 18 ( ( -LRB- cord-015021-pol2qm74 246 19 PBP PBP NNP cord-015021-pol2qm74 246 20 ) ) -RRB- cord-015021-pol2qm74 246 21 specificities specificity NNS cord-015021-pol2qm74 246 22 of of IN cord-015021-pol2qm74 246 23 the the DT cord-015021-pol2qm74 246 24 antibiotics antibiotic NNS cord-015021-pol2qm74 246 25 with with IN cord-015021-pol2qm74 246 26 resultant resultant JJ cord-015021-pol2qm74 246 27 differential differential JJ cord-015021-pol2qm74 246 28 morphological morphological JJ cord-015021-pol2qm74 246 29 changes change NNS cord-015021-pol2qm74 246 30 , , , cord-015021-pol2qm74 246 31 In in IN cord-015021-pol2qm74 246 32 a a DT cord-015021-pol2qm74 246 33 rat rat NN cord-015021-pol2qm74 246 34 sepsis sepsis NN cord-015021-pol2qm74 246 35 model model NN cord-015021-pol2qm74 246 36 treatment treatment NN cord-015021-pol2qm74 246 37 with with IN cord-015021-pol2qm74 246 38 imipenem imipenem NNP cord-015021-pol2qm74 246 39 or or CC cord-015021-pol2qm74 246 40 ceftazidime ceftazidime NNP cord-015021-pol2qm74 246 41 resulted result VBD cord-015021-pol2qm74 246 42 in in IN cord-015021-pol2qm74 246 43 a a DT cord-015021-pol2qm74 246 44 transient transient JJ cord-015021-pol2qm74 246 45 increase increase NN cord-015021-pol2qm74 246 46 in in IN cord-015021-pol2qm74 246 47 IL-6 IL-6 NNP cord-015021-pol2qm74 246 48 levels level NNS cord-015021-pol2qm74 246 49 , , , cord-015021-pol2qm74 246 50 whereas whereas IN cord-015021-pol2qm74 246 51 treatment treatment NN cord-015021-pol2qm74 246 52 with with IN cord-015021-pol2qm74 246 53 aztreonam aztreonam NNP cord-015021-pol2qm74 246 54 resulted result VBD cord-015021-pol2qm74 246 55 in in IN cord-015021-pol2qm74 246 56 progressively progressively RB cord-015021-pol2qm74 246 57 increasing increase VBG cord-015021-pol2qm74 246 58 levels level NNS cord-015021-pol2qm74 246 59 of of IN cord-015021-pol2qm74 246 60 IL-6 IL-6 NNP cord-015021-pol2qm74 246 61 and and CC cord-015021-pol2qm74 246 62 a a DT cord-015021-pol2qm74 246 63 significant significant JJ cord-015021-pol2qm74 246 64 increase increase NN cord-015021-pol2qm74 246 65 in in IN cord-015021-pol2qm74 246 66 mortality mortality NN cord-015021-pol2qm74 246 67 . . . cord-015021-pol2qm74 247 1 The the DT cord-015021-pol2qm74 247 2 increased increased JJ cord-015021-pol2qm74 247 3 mortality mortality NN cord-015021-pol2qm74 247 4 in in IN cord-015021-pol2qm74 247 5 PBP-3 PBP-3 NNP cord-015021-pol2qm74 247 6 specific specific JJ cord-015021-pol2qm74 247 7 aztreonam aztreonam NN cord-015021-pol2qm74 247 8 treated treat VBD cord-015021-pol2qm74 247 9 rats rat NNS cord-015021-pol2qm74 247 10 might may MD cord-015021-pol2qm74 247 11 have have VB cord-015021-pol2qm74 247 12 been be VBN cord-015021-pol2qm74 247 13 the the DT cord-015021-pol2qm74 247 14 result result NN cord-015021-pol2qm74 247 15 of of IN cord-015021-pol2qm74 247 16 filament filament NN cord-015021-pol2qm74 247 17 formation formation NN cord-015021-pol2qm74 247 18 in in IN cord-015021-pol2qm74 247 19 the the DT cord-015021-pol2qm74 247 20 abdominal abdominal JJ cord-015021-pol2qm74 247 21 cavity cavity NN cord-015021-pol2qm74 247 22 of of IN cord-015021-pol2qm74 247 23 the the DT cord-015021-pol2qm74 247 24 septic septic JJ cord-015021-pol2qm74 247 25 rats rat NNS cord-015021-pol2qm74 247 26 . . . cord-015021-pol2qm74 248 1 The the DT cord-015021-pol2qm74 248 2 endotoxin endotoxin NN cord-015021-pol2qm74 248 3 sequestered sequester VBN cord-015021-pol2qm74 248 4 at at IN cord-015021-pol2qm74 248 5 local local JJ cord-015021-pol2qm74 248 6 sites site NNS cord-015021-pol2qm74 248 7 may may MD cord-015021-pol2qm74 248 8 account account VB cord-015021-pol2qm74 248 9 for for IN cord-015021-pol2qm74 248 10 the the DT cord-015021-pol2qm74 248 11 precipitation precipitation NN cord-015021-pol2qm74 248 12 of of IN cord-015021-pol2qm74 248 13 gram gram NN cord-015021-pol2qm74 248 14 - - HYPH cord-015021-pol2qm74 248 15 negative negative JJ cord-015021-pol2qm74 248 16 shock shock NN cord-015021-pol2qm74 248 17 . . . cord-015021-pol2qm74 249 1 Finally finally RB cord-015021-pol2qm74 249 2 , , , cord-015021-pol2qm74 249 3 we -PRON- PRP cord-015021-pol2qm74 249 4 've have VB cord-015021-pol2qm74 249 5 also also RB cord-015021-pol2qm74 249 6 demonstrated demonstrate VBN cord-015021-pol2qm74 249 7 that that IN cord-015021-pol2qm74 249 8 in in IN cord-015021-pol2qm74 249 9 patients patient NNS cord-015021-pol2qm74 249 10 under under IN cord-015021-pol2qm74 249 11 treatment treatment NN cord-015021-pol2qm74 249 12 for for IN cord-015021-pol2qm74 249 13 septic septic JJ cord-015021-pol2qm74 249 14 shock shock NN cord-015021-pol2qm74 249 15 endotoxin endotoxin NN cord-015021-pol2qm74 249 16 release release NN cord-015021-pol2qm74 249 17 can can MD cord-015021-pol2qm74 249 18 be be VB cord-015021-pol2qm74 249 19 related relate VBN cord-015021-pol2qm74 249 20 to to IN cord-015021-pol2qm74 249 21 the the DT cord-015021-pol2qm74 249 22 administration administration NN cord-015021-pol2qm74 249 23 of of IN cord-015021-pol2qm74 249 24 antibiotics antibiotic NNS cord-015021-pol2qm74 249 25 . . . cord-015021-pol2qm74 250 1 Carbapenem Carbapenem NNP cord-015021-pol2qm74 250 2 - - : cord-015021-pol2qm74 250 3 and and CC cord-015021-pol2qm74 250 4 Cephalosporin Cephalosporin NNP cord-015021-pol2qm74 250 5 - - HYPH cord-015021-pol2qm74 250 6 lnduced lnduce VBN cord-015021-pol2qm74 250 7 Release Release NNP cord-015021-pol2qm74 250 8 of of IN cord-015021-pol2qm74 250 9 LPS LPS NNP cord-015021-pol2qm74 250 10 from from IN cord-015021-pol2qm74 250 11 Smooth smooth JJ cord-015021-pol2qm74 250 12 and and CC cord-015021-pol2qm74 250 13 Rough rough JJ cord-015021-pol2qm74 250 14 Pseudomonas Pseudomonas NNP cord-015021-pol2qm74 250 15 aeruginosa aeruginosa NN cord-015021-pol2qm74 250 16 : : : cord-015021-pol2qm74 251 1 In in IN cord-015021-pol2qm74 251 2 - - HYPH cord-015021-pol2qm74 251 3 Vivo Vivo NNP cord-015021-pol2qm74 251 4 Relevance relevance NN cord-015021-pol2qm74 251 5 J. J. NNP cord-015021-pol2qm74 251 6 Jackson Jackson NNP cord-015021-pol2qm74 251 7 and and CC cord-015021-pol2qm74 251 8 H. H. NNP cord-015021-pol2qm74 251 9 Kropp Kropp NNP cord-015021-pol2qm74 251 10 , , , cord-015021-pol2qm74 251 11 Merck Merck NNP cord-015021-pol2qm74 251 12 Research Research NNP cord-015021-pol2qm74 251 13 Laboratories Laboratories NNP cord-015021-pol2qm74 251 14 , , , cord-015021-pol2qm74 251 15 Rahway Rahway NNP cord-015021-pol2qm74 251 16 , , , cord-015021-pol2qm74 251 17 NJ NJ NNP cord-015021-pol2qm74 251 18 B B NNP cord-015021-pol2qm74 251 19 - - HYPH cord-015021-pol2qm74 251 20 lactam lactam NNP cord-015021-pol2qm74 251 21 ( ( -LRB- cord-015021-pol2qm74 251 22 cell cell NN cord-015021-pol2qm74 251 23 - - HYPH cord-015021-pol2qm74 251 24 wall wall NN cord-015021-pol2qm74 251 25 active active JJ cord-015021-pol2qm74 251 26 ) ) -RRB- cord-015021-pol2qm74 252 1 antibiotics antibiotic NNS cord-015021-pol2qm74 252 2 are be VBP cord-015021-pol2qm74 252 3 generally generally RB cord-015021-pol2qm74 252 4 deemed deem VBN cord-015021-pol2qm74 252 5 the the DT cord-015021-pol2qm74 252 6 class class NN cord-015021-pol2qm74 252 7 of of IN cord-015021-pol2qm74 252 8 antibiotics antibiotic NNS cord-015021-pol2qm74 252 9 most most RBS cord-015021-pol2qm74 252 10 responsible responsible JJ cord-015021-pol2qm74 252 11 for for IN cord-015021-pol2qm74 252 12 the the DT cord-015021-pol2qm74 252 13 release release NN cord-015021-pol2qm74 252 14 of of IN cord-015021-pol2qm74 252 15 free free JJ cord-015021-pol2qm74 252 16 endotoxin endotoxin NN cord-015021-pol2qm74 252 17 ( ( -LRB- cord-015021-pol2qm74 252 18 LPS LPS NNP cord-015021-pol2qm74 252 19 ) ) -RRB- cord-015021-pol2qm74 252 20 from from IN cord-015021-pol2qm74 252 21 gram gram NN cord-015021-pol2qm74 252 22 - - HYPH cord-015021-pol2qm74 252 23 negative negative JJ cord-015021-pol2qm74 252 24 bacteria bacteria NNS cord-015021-pol2qm74 252 25 due due IN cord-015021-pol2qm74 252 26 to to IN cord-015021-pol2qm74 252 27 their -PRON- PRP$ cord-015021-pol2qm74 252 28 cell cell NN cord-015021-pol2qm74 252 29 lytic lytic JJ cord-015021-pol2qm74 252 30 actions action NNS cord-015021-pol2qm74 252 31 although although IN cord-015021-pol2qm74 252 32 all all DT cord-015021-pol2qm74 252 33 antibiotic antibiotic JJ cord-015021-pol2qm74 252 34 classes class NNS cord-015021-pol2qm74 252 35 studied study VBD cord-015021-pol2qm74 252 36 thus thus RB cord-015021-pol2qm74 252 37 far far RB cord-015021-pol2qm74 252 38 induce induce VBP cord-015021-pol2qm74 252 39 release release NN cord-015021-pol2qm74 252 40 of of IN cord-015021-pol2qm74 252 41 endotoxin endotoxin NN cord-015021-pol2qm74 252 42 . . . cord-015021-pol2qm74 253 1 We -PRON- PRP cord-015021-pol2qm74 253 2 have have VBP cord-015021-pol2qm74 253 3 recently recently RB cord-015021-pol2qm74 253 4 shown show VBN cord-015021-pol2qm74 253 5 in in IN cord-015021-pol2qm74 253 6 - - HYPH cord-015021-pol2qm74 253 7 vitro vitro FW cord-015021-pol2qm74 253 8 that that IN cord-015021-pol2qm74 253 9 antibiotics antibiotic NNS cord-015021-pol2qm74 253 10 within within IN cord-015021-pol2qm74 253 11 the the DT cord-015021-pol2qm74 253 12 b b NN cord-015021-pol2qm74 253 13 - - HYPH cord-015021-pol2qm74 253 14 lactam lactam NN cord-015021-pol2qm74 253 15 class class NN cord-015021-pol2qm74 253 16 ( ( -LRB- cord-015021-pol2qm74 253 17 i.e. i.e. FW cord-015021-pol2qm74 253 18 imipenem imipenem NNP cord-015021-pol2qm74 253 19 , , , cord-015021-pol2qm74 253 20 meropenem meropenem NNP cord-015021-pol2qm74 253 21 and and CC cord-015021-pol2qm74 253 22 ceftazidime ceftazidime NNP cord-015021-pol2qm74 253 23 , , , cord-015021-pol2qm74 253 24 with with IN cord-015021-pol2qm74 253 25 equivalent equivalent JJ cord-015021-pol2qm74 253 26 MICs mic NNS cord-015021-pol2qm74 253 27 ) ) -RRB- cord-015021-pol2qm74 253 28 differ differ VBP cord-015021-pol2qm74 253 29 in in IN cord-015021-pol2qm74 253 30 their -PRON- PRP$ cord-015021-pol2qm74 253 31 propensities propensity NNS cord-015021-pol2qm74 253 32 to to TO cord-015021-pol2qm74 253 33 release release VB cord-015021-pol2qm74 253 34 excessive excessive JJ cord-015021-pol2qm74 253 35 amounts amount NNS cord-015021-pol2qm74 253 36 of of IN cord-015021-pol2qm74 253 37 LPS lp NNS cord-015021-pol2qm74 253 38 from from IN cord-015021-pol2qm74 253 39 both both DT cord-015021-pol2qm74 253 40 smooth-(s- smooth-(s- NNS cord-015021-pol2qm74 253 41 ) ) -RRB- cord-015021-pol2qm74 253 42 and and CC cord-015021-pol2qm74 253 43 rough-(r- rough-(r- NNP cord-015021-pol2qm74 253 44 ) ) -RRB- cord-015021-pol2qm74 254 1 LPS LPS NNP cord-015021-pol2qm74 254 2 laboratory laboratory NN cord-015021-pol2qm74 254 3 and and CC cord-015021-pol2qm74 254 4 clinical clinical JJ cord-015021-pol2qm74 254 5 and and CC cord-015021-pol2qm74 254 6 antibiotic antibiotic JJ cord-015021-pol2qm74 254 7 - - HYPH cord-015021-pol2qm74 254 8 sensitive sensitive JJ cord-015021-pol2qm74 254 9 and and CC cord-015021-pol2qm74 254 10 -resistant -resistant JJ cord-015021-pol2qm74 254 11 P. p. NN cord-015021-pol2qm74 254 12 aeruginosa aeruginosa NN cord-015021-pol2qm74 254 13 isolates isolate NNS cord-015021-pol2qm74 254 14 and and CC cord-015021-pol2qm74 254 15 that that IN cord-015021-pol2qm74 254 16 LPS LPS NNP cord-015021-pol2qm74 254 17 release release NN cord-015021-pol2qm74 254 18 is be VBZ cord-015021-pol2qm74 254 19 independent independent JJ cord-015021-pol2qm74 254 20 of of IN cord-015021-pol2qm74 254 21 cell cell NN cord-015021-pol2qm74 254 22 lysis lysis NN cord-015021-pol2qm74 254 23 . . . cord-015021-pol2qm74 255 1 Additionally additionally RB cord-015021-pol2qm74 255 2 , , , cord-015021-pol2qm74 255 3 variations variation NNS cord-015021-pol2qm74 255 4 in in IN cord-015021-pol2qm74 255 5 the the DT cord-015021-pol2qm74 255 6 induction induction NN cord-015021-pol2qm74 255 7 of of IN cord-015021-pol2qm74 255 8 endotoxin endotoxin NN cord-015021-pol2qm74 255 9 release release NN cord-015021-pol2qm74 255 10 is be VBZ cord-015021-pol2qm74 255 11 antibiotic antibiotic JJ cord-015021-pol2qm74 255 12 concentration concentration NN cord-015021-pol2qm74 255 13 dependant dependant JJ cord-015021-pol2qm74 255 14 and and CC cord-015021-pol2qm74 255 15 correlate correlate VB cord-015021-pol2qm74 255 16 with with IN cord-015021-pol2qm74 255 17 antibiotic antibiotic JJ cord-015021-pol2qm74 255 18 penicillin penicillin NN cord-015021-pol2qm74 255 19 - - HYPH cord-015021-pol2qm74 255 20 binding bind VBG cord-015021-pol2qm74 255 21 protein protein NN cord-015021-pol2qm74 255 22 ( ( -LRB- cord-015021-pol2qm74 255 23 PBP PBP NNP cord-015021-pol2qm74 255 24 ) ) -RRB- cord-015021-pol2qm74 255 25 affinities affinity NNS cord-015021-pol2qm74 255 26 which which WDT cord-015021-pol2qm74 255 27 result result VBP cord-015021-pol2qm74 255 28 in in IN cord-015021-pol2qm74 255 29 morphological morphological JJ cord-015021-pol2qm74 255 30 changes change NNS cord-015021-pol2qm74 255 31 . . . cord-015021-pol2qm74 256 1 These these DT cord-015021-pol2qm74 256 2 studies study NNS cord-015021-pol2qm74 256 3 also also RB cord-015021-pol2qm74 256 4 show show VBP cord-015021-pol2qm74 256 5 that that IN cord-015021-pol2qm74 256 6 LPS LPS NNP cord-015021-pol2qm74 256 7 differences difference NNS cord-015021-pol2qm74 256 8 measured measure VBN cord-015021-pol2qm74 256 9 via via IN cord-015021-pol2qm74 256 10 chromogenic chromogenic JJ cord-015021-pol2qm74 256 11 LPS LPS NNP cord-015021-pol2qm74 256 12 ( ( -LRB- cord-015021-pol2qm74 256 13 C C NNP cord-015021-pol2qm74 256 14 - - HYPH cord-015021-pol2qm74 256 15 LAL LAL NNP cord-015021-pol2qm74 256 16 ) ) -RRB- cord-015021-pol2qm74 256 17 assay assay NN cord-015021-pol2qm74 256 18 correlate correlate VBP cord-015021-pol2qm74 256 19 with with IN cord-015021-pol2qm74 256 20 LPS LPS NNP cord-015021-pol2qm74 256 21 lethality lethality NN cord-015021-pol2qm74 256 22 in in IN cord-015021-pol2qm74 256 23 LPS LPS NNP cord-015021-pol2qm74 256 24 - - HYPH cord-015021-pol2qm74 256 25 sensitive sensitive JJ cord-015021-pol2qm74 256 26 mice mouse NNS cord-015021-pol2qm74 256 27 . . . cord-015021-pol2qm74 257 1 Release Release NNP cord-015021-pol2qm74 257 2 of of IN cord-015021-pol2qm74 257 3 LPS LPS NNP cord-015021-pol2qm74 257 4 was be VBD cord-015021-pol2qm74 257 5 compared compare VBN cord-015021-pol2qm74 257 6 to to IN cord-015021-pol2qm74 257 7 changes change NNS cord-015021-pol2qm74 257 8 in in IN cord-015021-pol2qm74 257 9 CFUs cfus NN cord-015021-pol2qm74 257 10 , , , cord-015021-pol2qm74 257 11 cell cell NN cord-015021-pol2qm74 257 12 mass mass NN cord-015021-pol2qm74 257 13 , , , cord-015021-pol2qm74 257 14 morphology morphology NN cord-015021-pol2qm74 257 15 and and CC cord-015021-pol2qm74 257 16 antibiotic antibiotic JJ cord-015021-pol2qm74 257 17 PBP pbp NN cord-015021-pol2qm74 257 18 - - HYPH cord-015021-pol2qm74 257 19 specificity specificity NN cord-015021-pol2qm74 257 20 . . . cord-015021-pol2qm74 258 1 Corresponding correspond VBG cord-015021-pol2qm74 258 2 in in IN cord-015021-pol2qm74 258 3 - - HYPH cord-015021-pol2qm74 258 4 vivo vivo NN cord-015021-pol2qm74 258 5 studies study NNS cord-015021-pol2qm74 258 6 in in IN cord-015021-pol2qm74 258 7 CD1 CD1 NNP cord-015021-pol2qm74 258 8 mice mouse NNS cord-015021-pol2qm74 258 9 against against IN cord-015021-pol2qm74 259 1 s s NNP cord-015021-pol2qm74 259 2 - - HYPH cord-015021-pol2qm74 259 3 LPS LPS NNP cord-015021-pol2qm74 259 4 P. P. NNP cord-015021-pol2qm74 259 5 aeruginosa aeruginosa NN cord-015021-pol2qm74 259 6 isolates isolate NNS cord-015021-pol2qm74 259 7 show show VBP cord-015021-pol2qm74 259 8 that that IN cord-015021-pol2qm74 259 9 , , , cord-015021-pol2qm74 259 10 despite despite IN cord-015021-pol2qm74 259 11 equivalent equivalent JJ cord-015021-pol2qm74 259 12 in in IN cord-015021-pol2qm74 259 13 - - HYPH cord-015021-pol2qm74 259 14 vitro vitro FW cord-015021-pol2qm74 259 15 protection protection NN cord-015021-pol2qm74 259 16 , , , cord-015021-pol2qm74 259 17 antibiotic antibiotic JJ cord-015021-pol2qm74 259 18 efficacy efficacy NN cord-015021-pol2qm74 259 19 in in IN cord-015021-pol2qm74 259 20 mice mouse NNS cord-015021-pol2qm74 259 21 differ differ VBP cord-015021-pol2qm74 259 22 as as RB cord-015021-pol2qm74 259 23 much much JJ cord-015021-pol2qm74 259 24 as as IN cord-015021-pol2qm74 259 25 100-to 100-to CD cord-015021-pol2qm74 259 26 lO00-fold lo00-fold CD cord-015021-pol2qm74 259 27 . . . cord-015021-pol2qm74 260 1 To to TO cord-015021-pol2qm74 260 2 establish establish VB cord-015021-pol2qm74 260 3 a a DT cord-015021-pol2qm74 260 4 possible possible JJ cord-015021-pol2qm74 260 5 in in IN cord-015021-pol2qm74 260 6 - - HYPH cord-015021-pol2qm74 260 7 vivo vivo NN cord-015021-pol2qm74 260 8 role role NN cord-015021-pol2qm74 260 9 for for IN cord-015021-pol2qm74 260 10 antibiotic antibiotic NN cord-015021-pol2qm74 260 11 - - HYPH cord-015021-pol2qm74 260 12 induced induce VBN cord-015021-pol2qm74 260 13 release release NN cord-015021-pol2qm74 260 14 of of IN cord-015021-pol2qm74 260 15 free free JJ cord-015021-pol2qm74 260 16 LPS LPS NNP cord-015021-pol2qm74 260 17 we -PRON- PRP cord-015021-pol2qm74 260 18 compared compare VBD cord-015021-pol2qm74 260 19 antibiotic antibiotic JJ cord-015021-pol2qm74 260 20 efficacy efficacy NN cord-015021-pol2qm74 260 21 results result NNS cord-015021-pol2qm74 260 22 in in IN cord-015021-pol2qm74 260 23 mice mouse NNS cord-015021-pol2qm74 260 24 challenged challenge VBN cord-015021-pol2qm74 260 25 with with IN cord-015021-pol2qm74 260 26 virulent virulent JJ cord-015021-pol2qm74 260 27 parent parent NN cord-015021-pol2qm74 260 28 s s POS cord-015021-pol2qm74 260 29 - - HYPH cord-015021-pol2qm74 260 30 LPS LPS NNP cord-015021-pol2qm74 260 31 and and CC cord-015021-pol2qm74 260 32 its -PRON- PRP$ cord-015021-pol2qm74 260 33 relatively relatively RB cord-015021-pol2qm74 260 34 avirulent avirulent NN cord-015021-pol2qm74 260 35 r r NNP cord-015021-pol2qm74 260 36 - - HYPH cord-015021-pol2qm74 260 37 LPS LPS NNP cord-015021-pol2qm74 260 38 mutant mutant NN cord-015021-pol2qm74 260 39 ( ( -LRB- cord-015021-pol2qm74 260 40 lacking lack VBG cord-015021-pol2qm74 260 41 only only RB cord-015021-pol2qm74 260 42 its -PRON- PRP$ cord-015021-pol2qm74 260 43 0 0 CD cord-015021-pol2qm74 260 44 side side NN cord-015021-pol2qm74 260 45 chain chain NN cord-015021-pol2qm74 260 46 ) ) -RRB- cord-015021-pol2qm74 261 1 P. P. NNP cord-015021-pol2qm74 261 2 aeruginosa aeruginosa NN cord-015021-pol2qm74 261 3 isolates isolate NNS cord-015021-pol2qm74 261 4 . . . cord-015021-pol2qm74 262 1 Results result NNS cord-015021-pol2qm74 262 2 show show VBP cord-015021-pol2qm74 262 3 the the DT cord-015021-pol2qm74 262 4 relevance relevance NN cord-015021-pol2qm74 262 5 of of IN cord-015021-pol2qm74 262 6 quantity quantity NN cord-015021-pol2qm74 262 7 and and CC cord-015021-pol2qm74 262 8 physiochemical physiochemical JJ cord-015021-pol2qm74 262 9 composition composition NN cord-015021-pol2qm74 262 10 ( ( -LRB- cord-015021-pol2qm74 262 11 bioreactivity bioreactivity NNP cord-015021-pol2qm74 262 12 ) ) -RRB- cord-015021-pol2qm74 262 13 of of IN cord-015021-pol2qm74 262 14 free free JJ cord-015021-pol2qm74 262 15 LPS lp NNS cord-015021-pol2qm74 262 16 to to IN cord-015021-pol2qm74 262 17 virulence virulence NN cord-015021-pol2qm74 262 18 and and CC cord-015021-pol2qm74 262 19 in in IN cord-015021-pol2qm74 262 20 - - HYPH cord-015021-pol2qm74 262 21 vivo vivo NN cord-015021-pol2qm74 262 22 antibiotic antibiotic JJ cord-015021-pol2qm74 262 23 efficacy efficacy NN cord-015021-pol2qm74 262 24 . . . cord-015021-pol2qm74 263 1 In in IN cord-015021-pol2qm74 263 2 other other JJ cord-015021-pol2qm74 263 3 in in IN cord-015021-pol2qm74 263 4 - - HYPH cord-015021-pol2qm74 263 5 vivo vivo NN cord-015021-pol2qm74 263 6 studies study NNS cord-015021-pol2qm74 263 7 chemical chemical NN cord-015021-pol2qm74 263 8 agents agent NNS cord-015021-pol2qm74 263 9 that that WDT cord-015021-pol2qm74 263 10 destroy destroy VBP cord-015021-pol2qm74 263 11 cells cell NNS cord-015021-pol2qm74 263 12 ( ( -LRB- cord-015021-pol2qm74 263 13 m~ m~ XX cord-015021-pol2qm74 263 14 ) ) -RRB- cord-015021-pol2qm74 263 15 which which WDT cord-015021-pol2qm74 263 16 mediate mediate VBP cord-015021-pol2qm74 263 17 LPS LPS NNP cord-015021-pol2qm74 263 18 lethality lethality NN cord-015021-pol2qm74 263 19 in in IN cord-015021-pol2qm74 263 20 - - HYPH cord-015021-pol2qm74 263 21 vivo vivo NN cord-015021-pol2qm74 263 22 were be VBD cord-015021-pol2qm74 263 23 used use VBN cord-015021-pol2qm74 263 24 to to TO cord-015021-pol2qm74 263 25 pretreat pretreat VB cord-015021-pol2qm74 263 26 mice mouse NNS cord-015021-pol2qm74 263 27 prior prior RB cord-015021-pol2qm74 263 28 to to IN cord-015021-pol2qm74 263 29 antibiotic antibiotic JJ cord-015021-pol2qm74 263 30 therapy therapy NN cord-015021-pol2qm74 263 31 and and CC cord-015021-pol2qm74 263 32 bacterial bacterial JJ cord-015021-pol2qm74 263 33 challenge challenge NN cord-015021-pol2qm74 263 34 with with IN cord-015021-pol2qm74 263 35 wild wild JJ cord-015021-pol2qm74 263 36 type type NN cord-015021-pol2qm74 263 37 Pseudomonas Pseudomonas NNP cord-015021-pol2qm74 263 38 . . . cord-015021-pol2qm74 264 1 We -PRON- PRP cord-015021-pol2qm74 264 2 conclude conclude VBP cord-015021-pol2qm74 264 3 that that IN cord-015021-pol2qm74 264 4 circumstances circumstance NNS cord-015021-pol2qm74 264 5 in in IN cord-015021-pol2qm74 264 6 which which WDT cord-015021-pol2qm74 264 7 antibiotic antibiotic NN cord-015021-pol2qm74 264 8 - - HYPH cord-015021-pol2qm74 264 9 induced induce VBN cord-015021-pol2qm74 264 10 filamentation filamentation NN cord-015021-pol2qm74 264 11 occurs occur VBZ cord-015021-pol2qm74 264 12 are be VBP cord-015021-pol2qm74 264 13 also also RB cord-015021-pol2qm74 264 14 conditions condition NNS cord-015021-pol2qm74 264 15 that that WDT cord-015021-pol2qm74 264 16 yield yield VBP cord-015021-pol2qm74 264 17 excessive excessive JJ cord-015021-pol2qm74 264 18 LPS LPS NNP cord-015021-pol2qm74 264 19 release release NN cord-015021-pol2qm74 264 20 , , , cord-015021-pol2qm74 264 21 the the DT cord-015021-pol2qm74 264 22 in in IN cord-015021-pol2qm74 264 23 - - HYPH cord-015021-pol2qm74 264 24 vivo vivo NN cord-015021-pol2qm74 264 25 effects effect NNS cord-015021-pol2qm74 264 26 of of IN cord-015021-pol2qm74 264 27 which which WDT cord-015021-pol2qm74 264 28 are be VBP cord-015021-pol2qm74 264 29 shown show VBN cord-015021-pol2qm74 264 30 through through IN cord-015021-pol2qm74 264 31 the the DT cord-015021-pol2qm74 264 32 requirement requirement NN cord-015021-pol2qm74 264 33 of of IN cord-015021-pol2qm74 264 34 larger large JJR cord-015021-pol2qm74 264 35 amounts amount NNS cord-015021-pol2qm74 264 36 of of IN cord-015021-pol2qm74 264 37 antibiotic antibiotic NN cord-015021-pol2qm74 264 38 to to TO cord-015021-pol2qm74 264 39 afford afford VB cord-015021-pol2qm74 264 40 equivalent equivalent JJ cord-015021-pol2qm74 264 41 protection protection NN cord-015021-pol2qm74 264 42 . . . cord-015021-pol2qm74 265 1 Bacterial bacterial JJ cord-015021-pol2qm74 265 2 endotoxins endotoxin NNS cord-015021-pol2qm74 265 3 have have VBP cord-015021-pol2qm74 265 4 been be VBN cord-015021-pol2qm74 265 5 reported report VBN cord-015021-pol2qm74 265 6 to to TO cord-015021-pol2qm74 265 7 play play VB cord-015021-pol2qm74 265 8 a a DT cord-015021-pol2qm74 265 9 significant significant JJ cord-015021-pol2qm74 265 10 role role NN cord-015021-pol2qm74 265 11 in in IN cord-015021-pol2qm74 265 12 the the DT cord-015021-pol2qm74 265 13 pathogenesis pathogenesis NN cord-015021-pol2qm74 265 14 of of IN cord-015021-pol2qm74 265 15 Gram Gram NNP cord-015021-pol2qm74 265 16 negative negative JJ cord-015021-pol2qm74 265 17 sepsis sepsis NN cord-015021-pol2qm74 265 18 by by IN cord-015021-pol2qm74 265 19 their -PRON- PRP$ cord-015021-pol2qm74 265 20 interaction interaction NN cord-015021-pol2qm74 265 21 with with IN cord-015021-pol2qm74 265 22 , , , cord-015021-pol2qm74 265 23 and and CC cord-015021-pol2qm74 265 24 stimulation stimulation NN cord-015021-pol2qm74 265 25 of of IN cord-015021-pol2qm74 265 26 , , , cord-015021-pol2qm74 265 27 host host VBP cord-015021-pol2qm74 265 28 inflammatory inflammatory JJ cord-015021-pol2qm74 265 29 mediator mediator NN cord-015021-pol2qm74 265 30 cells cell NNS cord-015021-pol2qm74 265 31 to to TO cord-015021-pol2qm74 265 32 produce produce VB cord-015021-pol2qm74 265 33 cytokines cytokine NNS cord-015021-pol2qm74 265 34 , , , cord-015021-pol2qm74 265 35 biologically biologically RB cord-015021-pol2qm74 265 36 active active JJ cord-015021-pol2qm74 265 37 lipid lipid NN cord-015021-pol2qm74 265 38 intermediates intermediate NNS cord-015021-pol2qm74 265 39 , , , cord-015021-pol2qm74 265 40 and and CC cord-015021-pol2qm74 265 41 procoagulant procoagulant NN cord-015021-pol2qm74 265 42 activity activity NN cord-015021-pol2qm74 265 43 ( ( -LRB- cord-015021-pol2qm74 265 44 TFa TFa NNP cord-015021-pol2qm74 265 45 ) ) -RRB- cord-015021-pol2qm74 265 46 . . . cord-015021-pol2qm74 266 1 Although although IN cord-015021-pol2qm74 266 2 both both DT cord-015021-pol2qm74 266 3 microbe microbe NN cord-015021-pol2qm74 266 4 - - HYPH cord-015021-pol2qm74 266 5 associated associate VBN cord-015021-pol2qm74 266 6 and and CC cord-015021-pol2qm74 266 7 free free JJ cord-015021-pol2qm74 266 8 endotoxin endotoxin NN cord-015021-pol2qm74 266 9 are be VBP cord-015021-pol2qm74 266 10 capable capable JJ cord-015021-pol2qm74 266 11 of of IN cord-015021-pol2qm74 266 12 stimulating stimulate VBG cord-015021-pol2qm74 266 13 mediator mediator NN cord-015021-pol2qm74 266 14 production production NN cord-015021-pol2qm74 266 15 , , , cord-015021-pol2qm74 266 16 studies study NNS cord-015021-pol2qm74 266 17 from from IN cord-015021-pol2qm74 266 18 our -PRON- PRP$ cord-015021-pol2qm74 266 19 laboratory laboratory NN cord-015021-pol2qm74 266 20 suggest suggest VBP cord-015021-pol2qm74 266 21 that that IN cord-015021-pol2qm74 266 22 free free JJ cord-015021-pol2qm74 266 23 endotoxin endotoxin NN cord-015021-pol2qm74 266 24 may may MD cord-015021-pol2qm74 266 25 be be VB cord-015021-pol2qm74 266 26 the the DT cord-015021-pol2qm74 266 27 more more RBR cord-015021-pol2qm74 266 28 potent potent JJ cord-015021-pol2qm74 266 29 stimulus stimulus NN cord-015021-pol2qm74 266 30 for for IN cord-015021-pol2qm74 266 31 TNF TNF NNP cord-015021-pol2qm74 266 32 and and CC cord-015021-pol2qm74 266 33 TFa TFa NNP cord-015021-pol2qm74 266 34 . . . cord-015021-pol2qm74 267 1 Further further RB cord-015021-pol2qm74 267 2 , , , cord-015021-pol2qm74 267 3 our -PRON- PRP$ cord-015021-pol2qm74 267 4 studies study NNS cord-015021-pol2qm74 267 5 suggest suggest VBP cord-015021-pol2qm74 267 6 that that IN cord-015021-pol2qm74 267 7 the the DT cord-015021-pol2qm74 267 8 majority majority NN cord-015021-pol2qm74 267 9 of of IN cord-015021-pol2qm74 267 10 the the DT cord-015021-pol2qm74 267 11 proinflammatory proinflammatory JJ cord-015021-pol2qm74 267 12 activity activity NN cord-015021-pol2qm74 267 13 released release VBN cord-015021-pol2qm74 267 14 from from IN cord-015021-pol2qm74 267 15 antibiotictreated antibiotictreated JJ cord-015021-pol2qm74 267 16 E. E. NNP cord-015021-pol2qm74 267 17 coli coli VBZ cord-015021-pol2qm74 267 18 coisolates coisolate NNS cord-015021-pol2qm74 267 19 with with IN cord-015021-pol2qm74 267 20 LPS lp NNS cord-015021-pol2qm74 267 21 by by IN cord-015021-pol2qm74 267 22 two two CD cord-015021-pol2qm74 267 23 different different JJ cord-015021-pol2qm74 267 24 fractionation fractionation NN cord-015021-pol2qm74 267 25 techniques technique NNS cord-015021-pol2qm74 267 26 . . . cord-015021-pol2qm74 268 1 To to TO cord-015021-pol2qm74 268 2 assess assess VB cord-015021-pol2qm74 268 3 whether whether IN cord-015021-pol2qm74 268 4 actions action NNS cord-015021-pol2qm74 268 5 of of IN cord-015021-pol2qm74 268 6 endotoxin endotoxin NN cord-015021-pol2qm74 268 7 directly directly RB cord-015021-pol2qm74 268 8 contribute contribute VBP cord-015021-pol2qm74 268 9 to to IN cord-015021-pol2qm74 268 10 lethality lethality NN cord-015021-pol2qm74 268 11 in in IN cord-015021-pol2qm74 268 12 Gram Gram NNP cord-015021-pol2qm74 268 13 negative negative JJ cord-015021-pol2qm74 268 14 sepsis sepsis NN cord-015021-pol2qm74 268 15 , , , cord-015021-pol2qm74 268 16 an an DT cord-015021-pol2qm74 268 17 experimental experimental JJ cord-015021-pol2qm74 268 18 model model NN cord-015021-pol2qm74 268 19 was be VBD cord-015021-pol2qm74 268 20 developed develop VBN cord-015021-pol2qm74 268 21 in in IN cord-015021-pol2qm74 268 22 which which WDT cord-015021-pol2qm74 268 23 mice mouse NNS cord-015021-pol2qm74 268 24 were be VBD cord-015021-pol2qm74 268 25 made make VBN cord-015021-pol2qm74 268 26 hypersusceptihle hypersusceptihle NN cord-015021-pol2qm74 268 27 to to IN cord-015021-pol2qm74 268 28 the the DT cord-015021-pol2qm74 268 29 lethal lethal JJ cord-015021-pol2qm74 268 30 effects effect NNS cord-015021-pol2qm74 268 31 of of IN cord-015021-pol2qm74 268 32 endotoxin endotoxin NN cord-015021-pol2qm74 268 33 by by IN cord-015021-pol2qm74 268 34 treatment treatment NN cord-015021-pol2qm74 268 35 with with IN cord-015021-pol2qm74 268 36 D d NN cord-015021-pol2qm74 268 37 - - HYPH cord-015021-pol2qm74 268 38 galactosamine galactosamine NN cord-015021-pol2qm74 268 39 ( ( -LRB- cord-015021-pol2qm74 268 40 DgalN DgalN NNP cord-015021-pol2qm74 268 41 ) ) -RRB- cord-015021-pol2qm74 268 42 . . . cord-015021-pol2qm74 269 1 Challenge challenge NN cord-015021-pol2qm74 269 2 of of IN cord-015021-pol2qm74 269 3 CF-1 CF-1 NNP cord-015021-pol2qm74 269 4 DgalN DgalN NNP cord-015021-pol2qm74 269 5 - - HYPH cord-015021-pol2qm74 269 6 treated treat VBN cord-015021-pol2qm74 269 7 mice mouse NNS cord-015021-pol2qm74 269 8 with with IN cord-015021-pol2qm74 269 9 E. E. NNP cord-015021-pol2qm74 269 10 coli coli NNS cord-015021-pol2qm74 270 1 Olll Olll NNP cord-015021-pol2qm74 270 2 : : : cord-015021-pol2qm74 270 3 B4 B4 NNP cord-015021-pol2qm74 270 4 resulted result VBD cord-015021-pol2qm74 270 5 in in IN cord-015021-pol2qm74 270 6 an an DT cord-015021-pol2qm74 270 7 LDs0 lds0 NN cord-015021-pol2qm74 270 8 of of IN cord-015021-pol2qm74 270 9 approximately approximately RB cord-015021-pol2qm74 270 10 2.5 2.5 CD cord-015021-pol2qm74 270 11 x x SYM cord-015021-pol2qm74 270 12 104 104 CD cord-015021-pol2qm74 270 13 CFU CFU NNP cord-015021-pol2qm74 270 14 . . . cord-015021-pol2qm74 271 1 Resolution resolution NN cord-015021-pol2qm74 271 2 of of IN cord-015021-pol2qm74 271 3 the the DT cord-015021-pol2qm74 271 4 peritonitis peritonitis NN cord-015021-pol2qm74 271 5 and and CC cord-015021-pol2qm74 271 6 bacteremia bacteremia NN cord-015021-pol2qm74 271 7 by by IN cord-015021-pol2qm74 271 8 treatment treatment NN cord-015021-pol2qm74 271 9 with with IN cord-015021-pol2qm74 271 10 cell cell NN cord-015021-pol2qm74 271 11 wall wall NN cord-015021-pol2qm74 271 12 - - HYPH cord-015021-pol2qm74 271 13 active active JJ cord-015021-pol2qm74 271 14 antibiotics antibiotic NNS cord-015021-pol2qm74 271 15 resulted result VBD cord-015021-pol2qm74 271 16 in in IN cord-015021-pol2qm74 271 17 an an DT cord-015021-pol2qm74 271 18 increase increase NN cord-015021-pol2qm74 271 19 in in IN cord-015021-pol2qm74 271 20 the the DT cord-015021-pol2qm74 271 21 LDso LDso NNP cord-015021-pol2qm74 271 22 . . . cord-015021-pol2qm74 272 1 Ceftazidime Ceftazidime NNP cord-015021-pol2qm74 272 2 and and CC cord-015021-pol2qm74 272 3 imipenem imipenem NNP cord-015021-pol2qm74 272 4 , , , cord-015021-pol2qm74 272 5 which which WDT cord-015021-pol2qm74 272 6 differ differ VBP cord-015021-pol2qm74 272 7 in in IN cord-015021-pol2qm74 272 8 their -PRON- PRP$ cord-015021-pol2qm74 272 9 mechanism mechanism NN cord-015021-pol2qm74 272 10 of of IN cord-015021-pol2qm74 272 11 action action NN cord-015021-pol2qm74 272 12 and and CC cord-015021-pol2qm74 272 13 in in IN cord-015021-pol2qm74 272 14 their -PRON- PRP$ cord-015021-pol2qm74 272 15 capacity capacity NN cord-015021-pol2qm74 272 16 to to TO cord-015021-pol2qm74 272 17 effect effect VB cord-015021-pol2qm74 272 18 endotoxin endotoxin NN cord-015021-pol2qm74 272 19 release release NN cord-015021-pol2qm74 272 20 in in IN cord-015021-pol2qm74 272 21 vitro vitro FW cord-015021-pol2qm74 272 22 , , , cord-015021-pol2qm74 272 23 also also RB cord-015021-pol2qm74 272 24 differed differ VBD cord-015021-pol2qm74 272 25 in in IN cord-015021-pol2qm74 272 26 their -PRON- PRP$ cord-015021-pol2qm74 272 27 in in IN cord-015021-pol2qm74 272 28 vivo vivo NN cord-015021-pol2qm74 272 29 capacity capacity NN cord-015021-pol2qm74 272 30 to to TO cord-015021-pol2qm74 272 31 provide provide VB cord-015021-pol2qm74 272 32 chemotherapeutic chemotherapeutic JJ cord-015021-pol2qm74 272 33 protection protection NN cord-015021-pol2qm74 272 34 ( ( -LRB- cord-015021-pol2qm74 272 35 3 3 CD cord-015021-pol2qm74 272 36 fold fold NN cord-015021-pol2qm74 272 37 vs vs IN cord-015021-pol2qm74 272 38 8 8 CD cord-015021-pol2qm74 272 39 fold fold NN cord-015021-pol2qm74 272 40 respectively respectively RB cord-015021-pol2qm74 272 41 , , , cord-015021-pol2qm74 272 42 p p NN cord-015021-pol2qm74 272 43 < < XX cord-015021-pol2qm74 272 44 .01 .01 NFP cord-015021-pol2qm74 272 45 ) ) -RRB- cord-015021-pol2qm74 272 46 . . . cord-015021-pol2qm74 273 1 Parallel parallel JJ cord-015021-pol2qm74 273 2 studies study NNS cord-015021-pol2qm74 273 3 with with IN cord-015021-pol2qm74 273 4 endotoxin endotoxin NN cord-015021-pol2qm74 273 5 hyporesponsive hyporesponsive NNP cord-015021-pol2qm74 274 1 C3H C3H NNP cord-015021-pol2qm74 274 2 / / SYM cord-015021-pol2qm74 274 3 HeJ HeJ NNP cord-015021-pol2qm74 274 4 mice mouse NNS cord-015021-pol2qm74 274 5 indicate indicate VBP cord-015021-pol2qm74 274 6 significantly significantly RB cord-015021-pol2qm74 274 7 greater great JJR cord-015021-pol2qm74 274 8 levels level NNS cord-015021-pol2qm74 274 9 of of IN cord-015021-pol2qm74 274 10 protection protection NN cord-015021-pol2qm74 274 11 with with IN cord-015021-pol2qm74 274 12 imipenem imipenem NNP cord-015021-pol2qm74 274 13 ( ( -LRB- cord-015021-pol2qm74 274 14 > > NFP cord-015021-pol2qm74 274 15 80 80 CD cord-015021-pol2qm74 274 16 fold fold NN cord-015021-pol2qm74 274 17 vs vs IN cord-015021-pol2qm74 274 18 saline saline NN cord-015021-pol2qm74 274 19 controls control NNS cord-015021-pol2qm74 274 20 ) ) -RRB- cord-015021-pol2qm74 274 21 . . . cord-015021-pol2qm74 275 1 Collectively collectively RB cord-015021-pol2qm74 275 2 these these DT cord-015021-pol2qm74 275 3 data datum NNS cord-015021-pol2qm74 275 4 suggest suggest VBP cord-015021-pol2qm74 275 5 that that IN cord-015021-pol2qm74 275 6 endotoxin endotoxin NN cord-015021-pol2qm74 275 7 may may MD cord-015021-pol2qm74 275 8 contribute contribute VB cord-015021-pol2qm74 275 9 directly directly RB cord-015021-pol2qm74 275 10 to to IN cord-015021-pol2qm74 275 11 the the DT cord-015021-pol2qm74 275 12 pathogenesis pathogenesis NN cord-015021-pol2qm74 275 13 of of IN cord-015021-pol2qm74 275 14 experimental experimental JJ cord-015021-pol2qm74 275 15 Gram Gram NNP cord-015021-pol2qm74 275 16 negative negative JJ cord-015021-pol2qm74 275 17 sepsis sepsis NN cord-015021-pol2qm74 275 18 . . . cord-015021-pol2qm74 276 1 Bacterial bacterial JJ cord-015021-pol2qm74 276 2 lipopolysaccharides lipopolysaccharide NNS cord-015021-pol2qm74 276 3 ( ( -LRB- cord-015021-pol2qm74 276 4 LPS LPS NNP cord-015021-pol2qm74 276 5 ) ) -RRB- cord-015021-pol2qm74 276 6 are be VBP cord-015021-pol2qm74 276 7 the the DT cord-015021-pol2qm74 276 8 endotoxins endotoxin NNS cord-015021-pol2qm74 276 9 of of IN cord-015021-pol2qm74 276 10 gram gram NN cord-015021-pol2qm74 276 11 - - HYPH cord-015021-pol2qm74 276 12 negative negative JJ cord-015021-pol2qm74 276 13 bacteria bacteria NNS cord-015021-pol2qm74 276 14 and and CC cord-015021-pol2qm74 276 15 represent represent VBP cord-015021-pol2qm74 276 16 their -PRON- PRP$ cord-015021-pol2qm74 276 17 major major JJ cord-015021-pol2qm74 276 18 surface surface NN cord-015021-pol2qm74 276 19 antigens antigen NNS cord-015021-pol2qm74 276 20 . . . cord-015021-pol2qm74 277 1 LPS LPS NNP cord-015021-pol2qm74 277 2 is be VBZ cord-015021-pol2qm74 277 3 made make VBN cord-015021-pol2qm74 277 4 up up RP cord-015021-pol2qm74 277 5 of of IN cord-015021-pol2qm74 277 6 three three CD cord-015021-pol2qm74 277 7 chemically chemically RB cord-015021-pol2qm74 277 8 , , , cord-015021-pol2qm74 277 9 biologically biologically RB cord-015021-pol2qm74 277 10 and and CC cord-015021-pol2qm74 277 11 genetically genetically RB cord-015021-pol2qm74 277 12 disctinct disctinct JJ cord-015021-pol2qm74 277 13 regions region NNS cord-015021-pol2qm74 277 14 , , , cord-015021-pol2qm74 277 15 i.e i.e XX cord-015021-pol2qm74 277 16 , , , cord-015021-pol2qm74 277 17 the the DT cord-015021-pol2qm74 277 18 O o NN cord-015021-pol2qm74 277 19 - - HYPH cord-015021-pol2qm74 277 20 chain chain NN cord-015021-pol2qm74 277 21 , , , cord-015021-pol2qm74 277 22 the the DT cord-015021-pol2qm74 277 23 core core NN cord-015021-pol2qm74 277 24 region region NN cord-015021-pol2qm74 277 25 and and CC cord-015021-pol2qm74 277 26 the the DT cord-015021-pol2qm74 277 27 lipid lipid NN cord-015021-pol2qm74 277 28 A a DT cord-015021-pol2qm74 277 29 moiety moiety NN cord-015021-pol2qm74 277 30 whereby whereby WRB cord-015021-pol2qm74 277 31 the the DT cord-015021-pol2qm74 277 32 latter latter JJ cord-015021-pol2qm74 277 33 represents represent VBZ cord-015021-pol2qm74 277 34 the the DT cord-015021-pol2qm74 277 35 endotoxic endotoxic JJ cord-015021-pol2qm74 277 36 center center NN cord-015021-pol2qm74 277 37 . . . cord-015021-pol2qm74 278 1 It -PRON- PRP cord-015021-pol2qm74 278 2 is be VBZ cord-015021-pol2qm74 278 3 our -PRON- PRP$ cord-015021-pol2qm74 278 4 current current JJ cord-015021-pol2qm74 278 5 understanding understanding NN cord-015021-pol2qm74 278 6 that that IN cord-015021-pol2qm74 278 7 LPS LPS NNP cord-015021-pol2qm74 278 8 is be VBZ cord-015021-pol2qm74 278 9 responsible responsible JJ cord-015021-pol2qm74 278 10 for for IN cord-015021-pol2qm74 278 11 many many JJ cord-015021-pol2qm74 278 12 of of IN cord-015021-pol2qm74 278 13 the the DT cord-015021-pol2qm74 278 14 pathophysiological pathophysiological JJ cord-015021-pol2qm74 278 15 events event NNS cord-015021-pol2qm74 278 16 observed observe VBN cord-015021-pol2qm74 278 17 during during IN cord-015021-pol2qm74 278 18 gramnegative gramnegative JJ cord-015021-pol2qm74 278 19 infections infection NNS cord-015021-pol2qm74 278 20 and and CC cord-015021-pol2qm74 278 21 that that IN cord-015021-pol2qm74 278 22 one one CD cord-015021-pol2qm74 278 23 of of IN cord-015021-pol2qm74 278 24 the the DT cord-015021-pol2qm74 278 25 major major JJ cord-015021-pol2qm74 278 26 mechanisms mechanism NNS cord-015021-pol2qm74 278 27 leading lead VBG cord-015021-pol2qm74 278 28 to to IN cord-015021-pol2qm74 278 29 shock shock NN cord-015021-pol2qm74 278 30 and and CC cord-015021-pol2qm74 278 31 death death NN cord-015021-pol2qm74 278 32 is be VBZ cord-015021-pol2qm74 278 33 the the DT cord-015021-pol2qm74 278 34 LPS LPS NNP cord-015021-pol2qm74 278 35 - - HYPH cord-015021-pol2qm74 278 36 induced induce VBN cord-015021-pol2qm74 278 37 activation activation NN cord-015021-pol2qm74 278 38 of of IN cord-015021-pol2qm74 278 39 macrophages macrophage NNS cord-015021-pol2qm74 278 40 resulting result VBG cord-015021-pol2qm74 278 41 in in IN cord-015021-pol2qm74 278 42 the the DT cord-015021-pol2qm74 278 43 production production NN cord-015021-pol2qm74 278 44 and and CC cord-015021-pol2qm74 278 45 release release NN cord-015021-pol2qm74 278 46 of of IN cord-015021-pol2qm74 278 47 lipid lipid NN cord-015021-pol2qm74 278 48 and and CC cord-015021-pol2qm74 278 49 peptide peptide NN cord-015021-pol2qm74 278 50 mediators mediator NNS cord-015021-pol2qm74 278 51 , , , cord-015021-pol2qm74 278 52 among among IN cord-015021-pol2qm74 278 53 which which WDT cord-015021-pol2qm74 278 54 tumor tumor NN cord-015021-pol2qm74 278 55 necrosis necrosis NN cord-015021-pol2qm74 278 56 factor factor NN cord-015021-pol2qm74 278 57 seems seem VBZ cord-015021-pol2qm74 278 58 to to TO cord-015021-pol2qm74 278 59 be be VB cord-015021-pol2qm74 278 60 the the DT cord-015021-pol2qm74 278 61 most most RBS cord-015021-pol2qm74 278 62 important important JJ cord-015021-pol2qm74 278 63 . . . cord-015021-pol2qm74 279 1 Therefore therefore RB cord-015021-pol2qm74 279 2 , , , cord-015021-pol2qm74 279 3 in in IN cord-015021-pol2qm74 279 4 the the DT cord-015021-pol2qm74 279 5 fight fight NN cord-015021-pol2qm74 279 6 against against IN cord-015021-pol2qm74 279 7 the the DT cord-015021-pol2qm74 279 8 lethal lethal JJ cord-015021-pol2qm74 279 9 outcome outcome NN cord-015021-pol2qm74 279 10 of of IN cord-015021-pol2qm74 279 11 gram gram JJ cord-015021-pol2qm74 279 12 - - HYPH cord-015021-pol2qm74 279 13 negative negative JJ cord-015021-pol2qm74 279 14 infections infection NNS cord-015021-pol2qm74 279 15 , , , cord-015021-pol2qm74 279 16 modern modern JJ cord-015021-pol2qm74 279 17 strategies strategy NNS cord-015021-pol2qm74 279 18 , , , cord-015021-pol2qm74 279 19 in in IN cord-015021-pol2qm74 279 20 addition addition NN cord-015021-pol2qm74 279 21 to to IN cord-015021-pol2qm74 279 22 antibiotic antibiotic JJ cord-015021-pol2qm74 279 23 treatment treatment NN cord-015021-pol2qm74 279 24 , , , cord-015021-pol2qm74 279 25 aim aim VB cord-015021-pol2qm74 279 26 at at IN cord-015021-pol2qm74 279 27 i i NN cord-015021-pol2qm74 279 28 ) ) -RRB- cord-015021-pol2qm74 280 1 the the DT cord-015021-pol2qm74 280 2 neutralization neutralization NN cord-015021-pol2qm74 280 3 of of IN cord-015021-pol2qm74 280 4 tumor tumor NN cord-015021-pol2qm74 280 5 necrosis necrosis NN cord-015021-pol2qm74 280 6 factor factor NN cord-015021-pol2qm74 280 7 , , , cord-015021-pol2qm74 280 8 ii ii NN cord-015021-pol2qm74 280 9 ) ) -RRB- cord-015021-pol2qm74 281 1 the the DT cord-015021-pol2qm74 281 2 inhibition inhibition NN cord-015021-pol2qm74 281 3 of of IN cord-015021-pol2qm74 281 4 the the DT cord-015021-pol2qm74 281 5 production production NN cord-015021-pol2qm74 281 6 of of IN cord-015021-pol2qm74 281 7 tumor tumor NN cord-015021-pol2qm74 281 8 necrosis necrosis NN cord-015021-pol2qm74 281 9 factor factor NN cord-015021-pol2qm74 281 10 or or CC cord-015021-pol2qm74 281 11 iii iii NN cord-015021-pol2qm74 281 12 ) ) -RRB- cord-015021-pol2qm74 282 1 the the DT cord-015021-pol2qm74 282 2 neutralization neutralization NN cord-015021-pol2qm74 282 3 of of IN cord-015021-pol2qm74 282 4 the the DT cord-015021-pol2qm74 282 5 activation activation NN cord-015021-pol2qm74 282 6 potential potential NN cord-015021-pol2qm74 282 7 of of IN cord-015021-pol2qm74 282 8 LPS LPS NNP cord-015021-pol2qm74 282 9 for for IN cord-015021-pol2qm74 282 10 macrophages macrophage NNS cord-015021-pol2qm74 282 11 by by IN cord-015021-pol2qm74 282 12 monoclonal monoclonal JJ cord-015021-pol2qm74 282 13 , , , cord-015021-pol2qm74 282 14 preferably preferably RB cord-015021-pol2qm74 282 15 human human JJ cord-015021-pol2qm74 282 16 antibodies antibody NNS cord-015021-pol2qm74 282 17 . . . cord-015021-pol2qm74 283 1 The the DT cord-015021-pol2qm74 283 2 latter latter JJ cord-015021-pol2qm74 283 3 approach approach NN cord-015021-pol2qm74 283 4 , , , cord-015021-pol2qm74 283 5 to to TO cord-015021-pol2qm74 283 6 be be VB cord-015021-pol2qm74 283 7 effective effective JJ cord-015021-pol2qm74 283 8 against against IN cord-015021-pol2qm74 283 9 a a DT cord-015021-pol2qm74 283 10 broad broad JJ cord-015021-pol2qm74 283 11 spectrum spectrum NN cord-015021-pol2qm74 283 12 of of IN cord-015021-pol2qm74 283 13 gram gram NN cord-015021-pol2qm74 283 14 - - HYPH cord-015021-pol2qm74 283 15 negatives negative NNS cord-015021-pol2qm74 283 16 , , , cord-015021-pol2qm74 283 17 must must MD cord-015021-pol2qm74 283 18 be be VB cord-015021-pol2qm74 283 19 directed direct VBN cord-015021-pol2qm74 283 20 against against IN cord-015021-pol2qm74 283 21 common common JJ cord-015021-pol2qm74 283 22 structures structure NNS cord-015021-pol2qm74 283 23 of of IN cord-015021-pol2qm74 283 24 LPS LPS NNP cord-015021-pol2qm74 283 25 ( ( -LRB- cord-015021-pol2qm74 283 26 lipid lipid NN cord-015021-pol2qm74 283 27 A a NN cord-015021-pol2qm74 283 28 and and CC cord-015021-pol2qm74 283 29 core core NN cord-015021-pol2qm74 283 30 region region NN cord-015021-pol2qm74 283 31 ) ) -RRB- cord-015021-pol2qm74 283 32 . . . cord-015021-pol2qm74 284 1 The the DT cord-015021-pol2qm74 284 2 molecular molecular JJ cord-015021-pol2qm74 284 3 basis basis NN cord-015021-pol2qm74 284 4 of of IN cord-015021-pol2qm74 284 5 this this DT cord-015021-pol2qm74 284 6 approach approach NN cord-015021-pol2qm74 284 7 and and CC cord-015021-pol2qm74 284 8 the the DT cord-015021-pol2qm74 284 9 controversy controversy NN cord-015021-pol2qm74 284 10 in in IN cord-015021-pol2qm74 284 11 this this DT cord-015021-pol2qm74 284 12 field field NN cord-015021-pol2qm74 284 13 will will MD cord-015021-pol2qm74 284 14 be be VB cord-015021-pol2qm74 284 15 discussed discuss VBN cord-015021-pol2qm74 284 16 . . . cord-015021-pol2qm74 285 1 Passive passive JJ cord-015021-pol2qm74 285 2 immunotherapy immunotherapy NN cord-015021-pol2qm74 285 3 has have VBZ cord-015021-pol2qm74 285 4 been be VBN cord-015021-pol2qm74 285 5 used use VBN cord-015021-pol2qm74 285 6 since since IN cord-015021-pol2qm74 285 7 1893 1893 CD cord-015021-pol2qm74 285 8 , , , cord-015021-pol2qm74 285 9 when when WRB cord-015021-pol2qm74 285 10 von von NNP cord-015021-pol2qm74 285 11 Behring Behring NNP cord-015021-pol2qm74 285 12 described describe VBD cord-015021-pol2qm74 285 13 the the DT cord-015021-pol2qm74 285 14 administration administration NN cord-015021-pol2qm74 285 15 of of IN cord-015021-pol2qm74 285 16 immune immune JJ cord-015021-pol2qm74 285 17 horse horse NN cord-015021-pol2qm74 285 18 serum serum NN cord-015021-pol2qm74 285 19 to to TO cord-015021-pol2qm74 285 20 treat treat VB cord-015021-pol2qm74 285 21 a a DT cord-015021-pol2qm74 285 22 patient patient NN cord-015021-pol2qm74 285 23 with with IN cord-015021-pol2qm74 285 24 diphteria diphteria JJ cord-015021-pol2qm74 285 25 infection infection NN cord-015021-pol2qm74 285 26 . . . cord-015021-pol2qm74 286 1 Even even RB cord-015021-pol2qm74 286 2 if if IN cord-015021-pol2qm74 286 3 this this DT cord-015021-pol2qm74 286 4 therapy therapy NN cord-015021-pol2qm74 286 5 was be VBD cord-015021-pol2qm74 286 6 sometimes sometimes RB cord-015021-pol2qm74 286 7 successful successful JJ cord-015021-pol2qm74 286 8 in in IN cord-015021-pol2qm74 286 9 bacterial bacterial JJ cord-015021-pol2qm74 286 10 infections infection NNS cord-015021-pol2qm74 286 11 , , , cord-015021-pol2qm74 286 12 it -PRON- PRP cord-015021-pol2qm74 286 13 has have VBZ cord-015021-pol2qm74 286 14 been be VBN cord-015021-pol2qm74 286 15 largely largely RB cord-015021-pol2qm74 286 16 replaced replace VBN cord-015021-pol2qm74 286 17 by by IN cord-015021-pol2qm74 286 18 antibiotics antibiotic NNS cord-015021-pol2qm74 286 19 . . . cord-015021-pol2qm74 287 1 However however RB cord-015021-pol2qm74 287 2 , , , cord-015021-pol2qm74 287 3 antibiotics antibiotic NNS cord-015021-pol2qm74 287 4 have have VBP cord-015021-pol2qm74 287 5 their -PRON- PRP$ cord-015021-pol2qm74 287 6 limitations limitation NNS cord-015021-pol2qm74 287 7 , , , cord-015021-pol2qm74 287 8 especially especially RB cord-015021-pol2qm74 287 9 in in IN cord-015021-pol2qm74 287 10 critically critically RB cord-015021-pol2qm74 287 11 - - HYPH cord-015021-pol2qm74 287 12 ill ill JJ cord-015021-pol2qm74 287 13 patients patient NNS cord-015021-pol2qm74 287 14 . . . cord-015021-pol2qm74 288 1 To to TO cord-015021-pol2qm74 288 2 improve improve VB cord-015021-pol2qm74 288 3 outcome outcome NN cord-015021-pol2qm74 288 4 , , , cord-015021-pol2qm74 288 5 adjunctive adjunctive JJ cord-015021-pol2qm74 288 6 therapies therapy NNS cord-015021-pol2qm74 288 7 such such JJ cord-015021-pol2qm74 288 8 as as IN cord-015021-pol2qm74 288 9 immunotherapy immunotherapy NN cord-015021-pol2qm74 288 10 with with IN cord-015021-pol2qm74 288 11 polyclonal polyclonal JJ cord-015021-pol2qm74 288 12 and and CC cord-015021-pol2qm74 288 13 monoclonal monoclonal JJ cord-015021-pol2qm74 288 14 antibodies antibody NNS cord-015021-pol2qm74 288 15 particularly particularly RB cord-015021-pol2qm74 288 16 against against IN cord-015021-pol2qm74 288 17 endotoxin endotoxin NN cord-015021-pol2qm74 288 18 are be VBP cord-015021-pol2qm74 288 19 again again RB cord-015021-pol2qm74 288 20 considered consider VBN cord-015021-pol2qm74 288 21 . . . cord-015021-pol2qm74 289 1 The the DT cord-015021-pol2qm74 289 2 role role NN cord-015021-pol2qm74 289 3 of of IN cord-015021-pol2qm74 289 4 humoral humoral JJ cord-015021-pol2qm74 289 5 immunity immunity NN cord-015021-pol2qm74 289 6 in in IN cord-015021-pol2qm74 289 7 host host NN cord-015021-pol2qm74 289 8 defenses defense NNS cord-015021-pol2qm74 289 9 against against IN cord-015021-pol2qm74 289 10 bacterial bacterial JJ cord-015021-pol2qm74 289 11 infections infection NNS cord-015021-pol2qm74 289 12 is be VBZ cord-015021-pol2qm74 289 13 weU weU VBG cord-015021-pol2qm74 289 14 known know VBN cord-015021-pol2qm74 289 15 . . . cord-015021-pol2qm74 290 1 For for IN cord-015021-pol2qm74 290 2 instance instance NN cord-015021-pol2qm74 290 3 , , , cord-015021-pol2qm74 290 4 tile tile NN cord-015021-pol2qm74 290 5 importance importance NN cord-015021-pol2qm74 290 6 of of IN cord-015021-pol2qm74 290 7 antibodies antibody NNS cord-015021-pol2qm74 290 8 in in IN cord-015021-pol2qm74 290 9 the the DT cord-015021-pol2qm74 290 10 defense defense NN cord-015021-pol2qm74 290 11 against against IN cord-015021-pol2qm74 290 12 gramnegative gramnegative NNP cord-015021-pol2qm74 290 13 infections infection NNS cord-015021-pol2qm74 290 14 has have VBZ cord-015021-pol2qm74 290 15 been be VBN cord-015021-pol2qm74 290 16 established establish VBN cord-015021-pol2qm74 290 17 clinically clinically RB cord-015021-pol2qm74 290 18 by by IN cord-015021-pol2qm74 290 19 studies study NNS cord-015021-pol2qm74 290 20 relating relate VBG cord-015021-pol2qm74 290 21 the the DT cord-015021-pol2qm74 290 22 outcome outcome NN cord-015021-pol2qm74 290 23 of of IN cord-015021-pol2qm74 290 24 patients patient NNS cord-015021-pol2qm74 290 25 with with IN cord-015021-pol2qm74 290 26 gram gram JJ cord-015021-pol2qm74 290 27 - - HYPH cord-015021-pol2qm74 290 28 negative negative JJ cord-015021-pol2qm74 290 29 bacteremia bacteremia NN cord-015021-pol2qm74 290 30 to to IN cord-015021-pol2qm74 290 31 tilers tiler NNS cord-015021-pol2qm74 290 32 of of IN cord-015021-pol2qm74 290 33 antibodies antibody NNS cord-015021-pol2qm74 290 34 directed direct VBN cord-015021-pol2qm74 290 35 at at IN cord-015021-pol2qm74 290 36 the the DT cord-015021-pol2qm74 290 37 offending offend VBG cord-015021-pol2qm74 290 38 pathogens pathogen NNS cord-015021-pol2qm74 290 39 at at IN cord-015021-pol2qm74 290 40 the the DT cord-015021-pol2qm74 290 41 onset onset NN cord-015021-pol2qm74 290 42 ofbacteremia ofbacteremia NN cord-015021-pol2qm74 290 43 ( ( -LRB- cord-015021-pol2qm74 290 44 McCabe McCabe NNP cord-015021-pol2qm74 290 45 1972 1972 CD cord-015021-pol2qm74 290 46 ; ; : cord-015021-pol2qm74 290 47 Pollack Pollack NNP cord-015021-pol2qm74 290 48 1979 1979 CD cord-015021-pol2qm74 290 49 ) ) -RRB- cord-015021-pol2qm74 290 50 . . . cord-015021-pol2qm74 291 1 Ever ever RB cord-015021-pol2qm74 291 2 since since IN cord-015021-pol2qm74 291 3 we -PRON- PRP cord-015021-pol2qm74 291 4 know know VBP cord-015021-pol2qm74 291 5 the the DT cord-015021-pol2qm74 291 6 role role NN cord-015021-pol2qm74 291 7 of of IN cord-015021-pol2qm74 291 8 endotoxins endotoxin NNS cord-015021-pol2qm74 291 9 in in IN cord-015021-pol2qm74 291 10 the the DT cord-015021-pol2qm74 291 11 pathophysiology pathophysiology NN cord-015021-pol2qm74 291 12 of of IN cord-015021-pol2qm74 291 13 sepsis sepsis NN cord-015021-pol2qm74 291 14 , , , cord-015021-pol2qm74 291 15 antibodies antibody NNS cord-015021-pol2qm74 291 16 against against IN cord-015021-pol2qm74 291 17 the the DT cord-015021-pol2qm74 291 18 S S NNP cord-015021-pol2qm74 291 19 - - HYPH cord-015021-pol2qm74 291 20 and and CC cord-015021-pol2qm74 291 21 R R NNP cord-015021-pol2qm74 291 22 - - HYPH cord-015021-pol2qm74 291 23 LPS lp NNS cord-015021-pol2qm74 291 24 have have VBP cord-015021-pol2qm74 291 25 also also RB cord-015021-pol2qm74 291 26 been be VBN cord-015021-pol2qm74 291 27 detected detect VBN cord-015021-pol2qm74 291 28 in in IN cord-015021-pol2qm74 291 29 sepsis sepsis NN cord-015021-pol2qm74 291 30 patients patient NNS cord-015021-pol2qm74 291 31 . . . cord-015021-pol2qm74 292 1 The the DT cord-015021-pol2qm74 292 2 aim aim NN cord-015021-pol2qm74 292 3 of of IN cord-015021-pol2qm74 292 4 the the DT cord-015021-pol2qm74 292 5 administration administration NN cord-015021-pol2qm74 292 6 of of IN cord-015021-pol2qm74 292 7 IV IV NNP cord-015021-pol2qm74 292 8 / / SYM cord-015021-pol2qm74 292 9 G g NN cord-015021-pol2qm74 292 10 to to IN cord-015021-pol2qm74 292 11 the the DT cord-015021-pol2qm74 292 12 sepsis sepsis NN cord-015021-pol2qm74 292 13 patient patient NN cord-015021-pol2qm74 292 14 is be VBZ cord-015021-pol2qm74 292 15 as as IN cord-015021-pol2qm74 292 16 follows follow VBZ cord-015021-pol2qm74 292 17 : : : cord-015021-pol2qm74 293 1 1 1 LS cord-015021-pol2qm74 293 2 ) ) -RRB- cord-015021-pol2qm74 293 3 Enhancing enhancing NN cord-015021-pol2qm74 293 4 of of IN cord-015021-pol2qm74 293 5 opsonization opsonization NN cord-015021-pol2qm74 293 6 and and CC cord-015021-pol2qm74 293 7 phagocytosis(antibactericidaI phagocytosis(antibactericidaI NNP cord-015021-pol2qm74 293 8 activity activity NN cord-015021-pol2qm74 293 9 ) ) -RRB- cord-015021-pol2qm74 293 10 2 2 CD cord-015021-pol2qm74 293 11 ) ) -RRB- cord-015021-pol2qm74 294 1 Synergistic synergistic JJ cord-015021-pol2qm74 294 2 effects effect NNS cord-015021-pol2qm74 294 3 with with IN cord-015021-pol2qm74 294 4 [ [ -LRB- cord-015021-pol2qm74 294 5 3 3 CD cord-015021-pol2qm74 294 6 - - SYM cord-015021-pol2qm74 294 7 1actam 1actam CD cord-015021-pol2qm74 294 8 antibiotics antibiotic NNS cord-015021-pol2qm74 294 9 3 3 CD cord-015021-pol2qm74 294 10 ) ) -RRB- cord-015021-pol2qm74 295 1 Neutralization neutralization NN cord-015021-pol2qm74 295 2 of of IN cord-015021-pol2qm74 295 3 endotoxin endotoxin NN cord-015021-pol2qm74 295 4 , , , cord-015021-pol2qm74 295 5 the the DT cord-015021-pol2qm74 295 6 main main JJ cord-015021-pol2qm74 295 7 pathogenic pathogenic JJ cord-015021-pol2qm74 295 8 mediator mediator NN cord-015021-pol2qm74 295 9 of of IN cord-015021-pol2qm74 295 10 gram gram JJ cord-015021-pol2qm74 295 11 - - HYPH cord-015021-pol2qm74 295 12 negative negative JJ cord-015021-pol2qm74 295 13 sepsis sepsis NN cord-015021-pol2qm74 295 14 4 4 CD cord-015021-pol2qm74 295 15 ) ) -RRB- cord-015021-pol2qm74 296 1 Modulation modulation NN cord-015021-pol2qm74 296 2 and/or and/or CC cord-015021-pol2qm74 296 3 inhibition inhibition NN cord-015021-pol2qm74 296 4 of of IN cord-015021-pol2qm74 296 5 cytokine cytokine NN cord-015021-pol2qm74 296 6 release release NN cord-015021-pol2qm74 297 1 The the DT cord-015021-pol2qm74 297 2 enhancement enhancement NN cord-015021-pol2qm74 297 3 of of IN cord-015021-pol2qm74 297 4 opsonic opsonic JJ cord-015021-pol2qm74 297 5 - - HYPH cord-015021-pol2qm74 297 6 and and CC cord-015021-pol2qm74 297 7 phagocytic phagocytic NN cord-015021-pol2qm74 297 8 - - HYPH cord-015021-pol2qm74 297 9 activity activity NN cord-015021-pol2qm74 297 10 especially especially RB cord-015021-pol2qm74 297 11 with with IN cord-015021-pol2qm74 297 12 IgG igg NN cord-015021-pol2qm74 297 13 via via IN cord-015021-pol2qm74 297 14 Fc Fc NNP cord-015021-pol2qm74 297 15 and and CC cord-015021-pol2qm74 297 16 C3 C3 NNP cord-015021-pol2qm74 297 17 receptors receptor NNS cord-015021-pol2qm74 297 18 has have VBZ cord-015021-pol2qm74 297 19 been be VBN cord-015021-pol2qm74 297 20 well well RB cord-015021-pol2qm74 297 21 documented document VBN cord-015021-pol2qm74 297 22 . . . cord-015021-pol2qm74 298 1 Monoclonal monoclonal JJ cord-015021-pol2qm74 298 2 antiendotoxin antiendotoxin NN cord-015021-pol2qm74 298 3 antibodies antibody NNS cord-015021-pol2qm74 298 4 , , , cord-015021-pol2qm74 298 5 proven prove VBN cord-015021-pol2qm74 298 6 in in IN cord-015021-pol2qm74 298 7 clinical clinical JJ cord-015021-pol2qm74 298 8 studies study NNS cord-015021-pol2qm74 298 9 , , , cord-015021-pol2qm74 298 10 do do VBP cord-015021-pol2qm74 298 11 not not RB cord-015021-pol2qm74 298 12 appear appear VB cord-015021-pol2qm74 298 13 to to TO cord-015021-pol2qm74 298 14 neutralize neutralize VB cord-015021-pol2qm74 298 15 endotoxin endotoxin NN cord-015021-pol2qm74 298 16 in in IN cord-015021-pol2qm74 298 17 vitro vitro FW cord-015021-pol2qm74 298 18 and and CC cord-015021-pol2qm74 298 19 are be VBP cord-015021-pol2qm74 298 20 not not RB cord-015021-pol2qm74 298 21 reproducibly reproducibly RB cord-015021-pol2qm74 298 22 protective protective JJ cord-015021-pol2qm74 298 23 in in IN cord-015021-pol2qm74 298 24 animal animal NN cord-015021-pol2qm74 298 25 models model NNS cord-015021-pol2qm74 298 26 of of IN cord-015021-pol2qm74 298 27 sepsis sepsis NN cord-015021-pol2qm74 298 28 . . . cord-015021-pol2qm74 299 1 Also also RB cord-015021-pol2qm74 299 2 they -PRON- PRP cord-015021-pol2qm74 299 3 can can MD cord-015021-pol2qm74 299 4 not not RB cord-015021-pol2qm74 299 5 suppress suppress VB cord-015021-pol2qm74 299 6 endotoxin endotoxin NN cord-015021-pol2qm74 299 7 - - HYPH cord-015021-pol2qm74 299 8 induced induce VBN cord-015021-pol2qm74 299 9 TNF-~ TNF-~ NNP cord-015021-pol2qm74 299 10 , , , cord-015021-pol2qm74 299 11 IL-6 IL-6 NNP cord-015021-pol2qm74 299 12 release release NN cord-015021-pol2qm74 299 13 in in IN cord-015021-pol2qm74 299 14 mice mouse NNS cord-015021-pol2qm74 299 15 ( ( -LRB- cord-015021-pol2qm74 299 16 Baumgartner Baumgartner NNP cord-015021-pol2qm74 299 17 1990 1990 CD cord-015021-pol2qm74 299 18 , , , cord-015021-pol2qm74 299 19 Corriveau Corriveau NNP cord-015021-pol2qm74 299 20 and and CC cord-015021-pol2qm74 299 21 Danner Danner NNP cord-015021-pol2qm74 299 22 1993 1993 CD cord-015021-pol2qm74 299 23 ) ) -RRB- cord-015021-pol2qm74 299 24 . . . cord-015021-pol2qm74 300 1 In in IN cord-015021-pol2qm74 300 2 conlrast conlrast NN cord-015021-pol2qm74 300 3 , , , cord-015021-pol2qm74 300 4 recent recent JJ cord-015021-pol2qm74 300 5 studies study NNS cord-015021-pol2qm74 300 6 of of IN cord-015021-pol2qm74 300 7 a a DT cord-015021-pol2qm74 300 8 polyclonal polyclonal JJ cord-015021-pol2qm74 300 9 immunoglobulin immunoglobulin NN cord-015021-pol2qm74 300 10 preparation preparation NN cord-015021-pol2qm74 300 11 , , , cord-015021-pol2qm74 300 12 containing contain VBG cord-015021-pol2qm74 300 13 high high JJ cord-015021-pol2qm74 300 14 levels level NNS cord-015021-pol2qm74 300 15 of of IN cord-015021-pol2qm74 300 16 antibodies antibody NNS cord-015021-pol2qm74 300 17 against against IN cord-015021-pol2qm74 300 18 gram gram NN cord-015021-pol2qm74 300 19 - - HYPH cord-015021-pol2qm74 300 20 negative negative JJ cord-015021-pol2qm74 300 21 bacteria bacteria NNS cord-015021-pol2qm74 300 22 and and CC cord-015021-pol2qm74 300 23 their -PRON- PRP$ cord-015021-pol2qm74 300 24 O o NN cord-015021-pol2qm74 300 25 - - HYPH cord-015021-pol2qm74 300 26 antigen antigen NN cord-015021-pol2qm74 300 27 of of IN cord-015021-pol2qm74 300 28 LPS LPS NNP cord-015021-pol2qm74 300 29 in in IN cord-015021-pol2qm74 300 30 IgG IgG NNP cord-015021-pol2qm74 300 31 , , , cord-015021-pol2qm74 300 32 IgM IgM NNP cord-015021-pol2qm74 300 33 and and CC cord-015021-pol2qm74 300 34 IgA IgA NNP cord-015021-pol2qm74 300 35 classes class NNS cord-015021-pol2qm74 301 1 ( ( -LRB- cord-015021-pol2qm74 301 2 Pentaglobin Pentaglobin NNP cord-015021-pol2qm74 301 3 ® ® POS cord-015021-pol2qm74 301 4 ) ) -RRB- cord-015021-pol2qm74 301 5 provide provide VBP cord-015021-pol2qm74 301 6 evidence evidence NN cord-015021-pol2qm74 301 7 to to TO cord-015021-pol2qm74 301 8 neutralize neutralize VB cord-015021-pol2qm74 301 9 endotoxin endotoxin NN cord-015021-pol2qm74 301 10 . . . cord-015021-pol2qm74 302 1 This this DT cord-015021-pol2qm74 302 2 effect effect NN cord-015021-pol2qm74 302 3 is be VBZ cord-015021-pol2qm74 302 4 demonstrated demonstrate VBN cord-015021-pol2qm74 302 5 in in IN cord-015021-pol2qm74 302 6 vitro vitro FW cord-015021-pol2qm74 302 7 ( ( -LRB- cord-015021-pol2qm74 302 8 Berger Berger NNP cord-015021-pol2qm74 302 9 1990 1990 CD cord-015021-pol2qm74 302 10 ( ( -LRB- cord-015021-pol2qm74 302 11 Berger Berger NNP cord-015021-pol2qm74 302 12 , , , cord-015021-pol2qm74 302 13 1993 1993 CD cord-015021-pol2qm74 302 14 , , , cord-015021-pol2qm74 302 15 in in IN cord-015021-pol2qm74 302 16 animal animal NN cord-015021-pol2qm74 302 17 models model NNS cord-015021-pol2qm74 302 18 ( ( -LRB- cord-015021-pol2qm74 302 19 Stephan Stephan NNP cord-015021-pol2qm74 302 20 1985 1985 CD cord-015021-pol2qm74 302 21 , , , cord-015021-pol2qm74 302 22 Berger Berger NNP cord-015021-pol2qm74 302 23 1993 1993 CD cord-015021-pol2qm74 302 24 and and CC cord-015021-pol2qm74 302 25 also also RB cord-015021-pol2qm74 302 26 in in IN cord-015021-pol2qm74 302 27 prospective prospective JJ cord-015021-pol2qm74 302 28 , , , cord-015021-pol2qm74 302 29 randomized randomized JJ cord-015021-pol2qm74 302 30 , , , cord-015021-pol2qm74 302 31 controlled control VBN cord-015021-pol2qm74 302 32 clinical clinical JJ cord-015021-pol2qm74 302 33 trials trial NNS cord-015021-pol2qm74 302 34 ( ( -LRB- cord-015021-pol2qm74 302 35 Schedel Schedel NNP cord-015021-pol2qm74 302 36 1991 1991 CD cord-015021-pol2qm74 302 37 , , , cord-015021-pol2qm74 302 38 Poynton Poynton NNP cord-015021-pol2qm74 302 39 1992 1992 CD cord-015021-pol2qm74 302 40 , , , cord-015021-pol2qm74 302 41 Behre Behre NNP cord-015021-pol2qm74 302 42 1992 1992 CD cord-015021-pol2qm74 302 43 . . . cord-015021-pol2qm74 303 1 Furthermore furthermore RB cord-015021-pol2qm74 303 2 mortali mortali NNP cord-015021-pol2qm74 303 3 b b NNP cord-015021-pol2qm74 303 4 ' ' '' cord-015021-pol2qm74 303 5 was be VBD cord-015021-pol2qm74 303 6 reduced reduce VBN cord-015021-pol2qm74 303 7 statistically statistically RB cord-015021-pol2qm74 303 8 in in IN cord-015021-pol2qm74 303 9 patients patient NNS cord-015021-pol2qm74 303 10 with with IN cord-015021-pol2qm74 303 11 septic septic JJ cord-015021-pol2qm74 303 12 shock shock NN cord-015021-pol2qm74 303 13 and and CC cord-015021-pol2qm74 303 14 endotoxemia endotoxemia NN cord-015021-pol2qm74 303 15 by by IN cord-015021-pol2qm74 303 16 using use VBG cord-015021-pol2qm74 303 17 this this DT cord-015021-pol2qm74 303 18 preparation preparation NN cord-015021-pol2qm74 303 19 , , , cord-015021-pol2qm74 303 20 as as IN cord-015021-pol2qm74 303 21 has have VBZ cord-015021-pol2qm74 303 22 been be VBN cord-015021-pol2qm74 303 23 demonstrated demonstrate VBN cord-015021-pol2qm74 303 24 by by IN cord-015021-pol2qm74 303 25 Sehedel Sehedel NNP cord-015021-pol2qm74 303 26 . . . cord-015021-pol2qm74 304 1 Anti anti JJ cord-015021-pol2qm74 304 2 - - JJ cord-015021-pol2qm74 304 3 core core JJ cord-015021-pol2qm74 304 4 LPS LPS NNP cord-015021-pol2qm74 304 5 monoolonal monoolonal JJ cord-015021-pol2qm74 304 6 antibodies antibody NNS cord-015021-pol2qm74 304 7 : : : cord-015021-pol2qm74 304 8 Binding bind VBG cord-015021-pol2qm74 304 9 specificity specificity NN cord-015021-pol2qm74 304 10 and and CC cord-015021-pol2qm74 304 11 biological biological JJ cord-015021-pol2qm74 304 12 properties property NNS cord-015021-pol2qm74 304 13 F.E. F.E. NNP cord-015021-pol2qm74 304 14 Di Di NNP cord-015021-pol2qm74 304 15 Padova Padova NNP cord-015021-pol2qm74 304 16 , , , cord-015021-pol2qm74 304 17 R. R. NNP cord-015021-pol2qm74 304 18 Barclay Barclay NNP cord-015021-pol2qm74 304 19 , , , cord-015021-pol2qm74 304 20 E.Th E.Th NNP cord-015021-pol2qm74 304 21 . . . cord-015021-pol2qm74 305 1 Rietschel Rietschel NNP cord-015021-pol2qm74 305 2 . . . cord-015021-pol2qm74 306 1 Bacterial bacterial JJ cord-015021-pol2qm74 306 2 LPS lp NNS cord-015021-pol2qm74 306 3 and and CC cord-015021-pol2qm74 306 4 cytokines cytokine NNS cord-015021-pol2qm74 306 5 are be VBP cord-015021-pol2qm74 306 6 responsible responsible JJ cord-015021-pol2qm74 306 7 for for IN cord-015021-pol2qm74 306 8 the the DT cord-015021-pol2qm74 306 9 pathological pathological JJ cord-015021-pol2qm74 306 10 processes process NNS cord-015021-pol2qm74 306 11 of of IN cord-015021-pol2qm74 306 12 Gram gram NN cord-015021-pol2qm74 306 13 - - HYPH cord-015021-pol2qm74 306 14 sepsis sepsis NN cord-015021-pol2qm74 306 15 and and CC cord-015021-pol2qm74 306 16 are be VBP cord-015021-pol2qm74 306 17 suitable suitable JJ cord-015021-pol2qm74 306 18 targets target NNS cord-015021-pol2qm74 306 19 for for IN cord-015021-pol2qm74 306 20 therapeutic therapeutic JJ cord-015021-pol2qm74 306 21 interventions intervention NNS cord-015021-pol2qm74 306 22 . . . cord-015021-pol2qm74 307 1 Chemical chemical JJ cord-015021-pol2qm74 307 2 characterization characterization NN cord-015021-pol2qm74 307 3 and and CC cord-015021-pol2qm74 307 4 structural structural JJ cord-015021-pol2qm74 307 5 analysis analysis NN cord-015021-pol2qm74 307 6 of of IN cord-015021-pol2qm74 307 7 different different JJ cord-015021-pol2qm74 307 8 LPS lp NNS cord-015021-pol2qm74 307 9 have have VBP cord-015021-pol2qm74 307 10 revealed reveal VBN cord-015021-pol2qm74 307 11 common common JJ cord-015021-pol2qm74 307 12 features feature NNS cord-015021-pol2qm74 307 13 . . . cord-015021-pol2qm74 308 1 The the DT cord-015021-pol2qm74 308 2 inner inner JJ cord-015021-pol2qm74 308 3 core core NN cord-015021-pol2qm74 308 4 region region NN cord-015021-pol2qm74 308 5 of of IN cord-015021-pol2qm74 308 6 LPS LPS NNP cord-015021-pol2qm74 308 7 shows show VBZ cord-015021-pol2qm74 308 8 a a DT cord-015021-pol2qm74 308 9 high high JJ cord-015021-pol2qm74 308 10 degree degree NN cord-015021-pol2qm74 308 11 of of IN cord-015021-pol2qm74 308 12 similarity similarity NN cord-015021-pol2qm74 308 13 among among IN cord-015021-pol2qm74 308 14 E. E. NNP cord-015021-pol2qm74 308 15 coli coli NNS cord-015021-pol2qm74 308 16 , , , cord-015021-pol2qm74 308 17 Salmonella Salmonella NNP cord-015021-pol2qm74 308 18 and and CC cord-015021-pol2qm74 308 19 Shigella Shigella NNP cord-015021-pol2qm74 308 20 . . . cord-015021-pol2qm74 309 1 Among among IN cord-015021-pol2qm74 309 2 a a DT cord-015021-pol2qm74 309 3 large large JJ cord-015021-pol2qm74 309 4 number number NN cord-015021-pol2qm74 309 5 of of IN cord-015021-pol2qm74 309 6 broadly broadly RB cord-015021-pol2qm74 309 7 cross cross JJ cord-015021-pol2qm74 309 8 - - JJ cord-015021-pol2qm74 309 9 reactive reactive JJ cord-015021-pol2qm74 309 10 murine murine JJ cord-015021-pol2qm74 309 11 anti anti JJ cord-015021-pol2qm74 309 12 - - JJ cord-015021-pol2qm74 309 13 core core JJ cord-015021-pol2qm74 309 14 LPS lp NNS cord-015021-pol2qm74 309 15 MAb MAb NNPS cord-015021-pol2qm74 309 16 one one CD cord-015021-pol2qm74 309 17 of of IN cord-015021-pol2qm74 309 18 these these DT cord-015021-pol2qm74 309 19 _SP cord-015021-pol2qm74 309 20 IgG2ak IgG2ak NNP cord-015021-pol2qm74 309 21 ) ) -RRB- cord-015021-pol2qm74 309 22 has have VBZ cord-015021-pol2qm74 309 23 been be VBN cord-015021-pol2qm74 309 24 selected select VBN cord-015021-pol2qm74 309 25 and and CC cord-015021-pol2qm74 309 26 chimerized chimerize VBN cord-015021-pol2qm74 309 27 into into IN cord-015021-pol2qm74 309 28 a a DT cord-015021-pol2qm74 309 29 human human JJ cord-015021-pol2qm74 309 30 IgGlk IgGlk NNP cord-015021-pol2qm74 309 31 ( ( -LRB- cord-015021-pol2qm74 309 32 SDZ SDZ NNP cord-015021-pol2qm74 309 33 219 219 CD cord-015021-pol2qm74 309 34 - - SYM cord-015021-pol2qm74 309 35 800 800 CD cord-015021-pol2qm74 309 36 ) ) -RRB- cord-015021-pol2qm74 309 37 . . . cord-015021-pol2qm74 310 1 In in IN cord-015021-pol2qm74 310 2 ELISA ELISA NNP cord-015021-pol2qm74 310 3 and and CC cord-015021-pol2qm74 310 4 in in IN cord-015021-pol2qm74 310 5 immunoblots immunoblot NNS cord-015021-pol2qm74 310 6 on on IN cord-015021-pol2qm74 310 7 purified purify VBN cord-015021-pol2qm74 310 8 LPS LPS NNP cord-015021-pol2qm74 310 9 both both CC cord-015021-pol2qm74 310 10 SDZ SDZ NNP cord-015021-pol2qm74 310 11 219 219 CD cord-015021-pol2qm74 310 12 - - SYM cord-015021-pol2qm74 310 13 800 800 CD cord-015021-pol2qm74 310 14 and and CC cord-015021-pol2qm74 310 15 WNI WNI NNP cord-015021-pol2qm74 310 16 222 222 CD cord-015021-pol2qm74 310 17 - - SYM cord-015021-pol2qm74 310 18 5 5 CD cord-015021-pol2qm74 310 19 show show VBP cord-015021-pol2qm74 310 20 a a DT cord-015021-pol2qm74 310 21 strong strong JJ cord-015021-pol2qm74 310 22 reactivity reactivity NN cord-015021-pol2qm74 310 23 with with IN cord-015021-pol2qm74 310 24 all all DT cord-015021-pol2qm74 310 25 smooth smooth JJ cord-015021-pol2qm74 310 26 LPS lp NNS cord-015021-pol2qm74 310 27 from from IN cord-015021-pol2qm74 310 28 E. E. NNP cord-015021-pol2qm74 310 29 coli coli NNS cord-015021-pol2qm74 310 30 and and CC cord-015021-pol2qm74 310 31 Salmonella Salmonella NNP cord-015021-pol2qm74 310 32 . . . cord-015021-pol2qm74 311 1 Reactivity reactivity NN cord-015021-pol2qm74 311 2 with with IN cord-015021-pol2qm74 311 3 all all PDT cord-015021-pol2qm74 311 4 the the DT cord-015021-pol2qm74 311 5 known know VBN cord-015021-pol2qm74 311 6 complete complete JJ cord-015021-pol2qm74 311 7 core core NN cord-015021-pol2qm74 311 8 structures structure NNS cord-015021-pol2qm74 311 9 from from IN cord-015021-pol2qm74 311 10 E. E. NNP cord-015021-pol2qm74 311 11 coli coli NNS cord-015021-pol2qm74 311 12 and and CC cord-015021-pol2qm74 311 13 Salmonella Salmonella NNP cord-015021-pol2qm74 311 14 ( ( -LRB- cord-015021-pol2qm74 311 15 Ra Ra NNP cord-015021-pol2qm74 311 16 ) ) -RRB- cord-015021-pol2qm74 311 17 is be VBZ cord-015021-pol2qm74 311 18 evident evident JJ cord-015021-pol2qm74 311 19 . . . cord-015021-pol2qm74 312 1 Reactivity reactivity NN cord-015021-pol2qm74 312 2 with with IN cord-015021-pol2qm74 312 3 Re Re VBG cord-015021-pol2qm74 312 4 structures structure NNS cord-015021-pol2qm74 312 5 or or CC cord-015021-pol2qm74 312 6 free free JJ cord-015021-pol2qm74 312 7 lipid lipid NN cord-015021-pol2qm74 312 8 A a NN cord-015021-pol2qm74 312 9 is be VBZ cord-015021-pol2qm74 312 10 not not RB cord-015021-pol2qm74 312 11 observed observe VBN cord-015021-pol2qm74 312 12 . . . cord-015021-pol2qm74 313 1 This this DT cord-015021-pol2qm74 313 2 MAb MAb VBZ cord-015021-pol2qm74 313 3 cressreacts cressreact VBZ cord-015021-pol2qm74 313 4 with with IN cord-015021-pol2qm74 313 5 all all DT cord-015021-pol2qm74 313 6 clinical clinical JJ cord-015021-pol2qm74 313 7 E. E. NNP cord-015021-pol2qm74 313 8 coli coli NNS cord-015021-pol2qm74 313 9 isolates isolate NNS cord-015021-pol2qm74 313 10 from from IN cord-015021-pol2qm74 313 11 blood blood NN cord-015021-pol2qm74 313 12 , , , cord-015021-pol2qm74 313 13 urine urine NN cord-015021-pol2qm74 313 14 and and CC cord-015021-pol2qm74 313 15 feces fece NNS cord-015021-pol2qm74 313 16 and and CC cord-015021-pol2qm74 313 17 with with IN cord-015021-pol2qm74 313 18 other other JJ cord-015021-pol2qm74 313 19 enterobacteriaceae enterobacteriaceae NNS cord-015021-pol2qm74 313 20 . . . cord-015021-pol2qm74 314 1 SDZ SDZ NNP cord-015021-pol2qm74 314 2 219 219 CD cord-015021-pol2qm74 314 3 - - SYM cord-015021-pol2qm74 314 4 800 800 CD cord-015021-pol2qm74 314 5 and and CC cord-015021-pol2qm74 314 6 WNI WNI NNP cord-015021-pol2qm74 314 7 222 222 CD cord-015021-pol2qm74 314 8 - - SYM cord-015021-pol2qm74 314 9 5 5 CD cord-015021-pol2qm74 314 10 have have VBP cord-015021-pol2qm74 314 11 biological biological JJ cord-015021-pol2qm74 314 12 activity activity NN cord-015021-pol2qm74 314 13 as as IN cord-015021-pol2qm74 314 14 they -PRON- PRP cord-015021-pol2qm74 314 15 inhibit inhibit VBP cord-015021-pol2qm74 314 16 the the DT cord-015021-pol2qm74 314 17 LAL LAL NNP cord-015021-pol2qm74 314 18 assay assay NN cord-015021-pol2qm74 314 19 and and CC cord-015021-pol2qm74 314 20 the the DT cord-015021-pol2qm74 314 21 secretion secretion NN cord-015021-pol2qm74 314 22 of of IN cord-015021-pol2qm74 314 23 monokines monokines NNP cord-015021-pol2qm74 314 24 ( ( -LRB- cord-015021-pol2qm74 314 25 IL-6 IL-6 NNP cord-015021-pol2qm74 314 26 and and CC cord-015021-pol2qm74 314 27 TNF TNF NNP cord-015021-pol2qm74 314 28 ) ) -RRB- cord-015021-pol2qm74 314 29 by by IN cord-015021-pol2qm74 314 30 mouse mouse NN cord-015021-pol2qm74 314 31 and and CC cord-015021-pol2qm74 314 32 human human JJ cord-015021-pol2qm74 314 33 macrophages macrophage NNS cord-015021-pol2qm74 314 34 . . . cord-015021-pol2qm74 315 1 Moreover moreover RB cord-015021-pol2qm74 315 2 , , , cord-015021-pol2qm74 315 3 SDZ SDZ NNP cord-015021-pol2qm74 315 4 219 219 CD cord-015021-pol2qm74 315 5 - - SYM cord-015021-pol2qm74 315 6 800 800 CD cord-015021-pol2qm74 315 7 and and CC cord-015021-pol2qm74 315 8 WNI WNI NNP cord-015021-pol2qm74 315 9 222 222 CD cord-015021-pol2qm74 315 10 - - SYM cord-015021-pol2qm74 315 11 5 5 CD cord-015021-pol2qm74 315 12 inhibit inhibit VBP cord-015021-pol2qm74 315 13 the the DT cord-015021-pol2qm74 315 14 release release NN cord-015021-pol2qm74 315 15 of of IN cord-015021-pol2qm74 315 16 IL-6 IL-6 NNP cord-015021-pol2qm74 315 17 and and CC cord-015021-pol2qm74 315 18 TNF TNF NNP cord-015021-pol2qm74 315 19 in in IN cord-015021-pol2qm74 315 20 vivo vivo NNP cord-015021-pol2qm74 315 21 . . . cord-015021-pol2qm74 316 1 In in IN cord-015021-pol2qm74 316 2 vivo vivo NNP cord-015021-pol2qm74 316 3 SDZ SDZ NNP cord-015021-pol2qm74 316 4 219 219 CD cord-015021-pol2qm74 316 5 - - SYM cord-015021-pol2qm74 316 6 800 800 CD cord-015021-pol2qm74 316 7 as as RB cord-015021-pol2qm74 316 8 well well RB cord-015021-pol2qm74 316 9 as as IN cord-015021-pol2qm74 316 10 WNI WNI NNP cord-015021-pol2qm74 316 11 222 222 CD cord-015021-pol2qm74 316 12 - - SYM cord-015021-pol2qm74 316 13 5 5 CD cord-015021-pol2qm74 316 14 neutralize neutralize VB cord-015021-pol2qm74 316 15 the the DT cord-015021-pol2qm74 316 16 pyrogenic pyrogenic JJ cord-015021-pol2qm74 316 17 activity activity NN cord-015021-pol2qm74 316 18 of of IN cord-015021-pol2qm74 316 19 E. E. NNP cord-015021-pol2qm74 316 20 coli coli VBZ cord-015021-pol2qm74 316 21 LPS lp NNS cord-015021-pol2qm74 316 22 and and CC cord-015021-pol2qm74 316 23 protect protect VB cord-015021-pol2qm74 316 24 mice mouse NNS cord-015021-pol2qm74 316 25 from from IN cord-015021-pol2qm74 316 26 lethality lethality NN cord-015021-pol2qm74 316 27 in in IN cord-015021-pol2qm74 316 28 D D NNP cord-015021-pol2qm74 316 29 - - HYPH cord-015021-pol2qm74 316 30 GaiN gain NN cord-015021-pol2qm74 316 31 - - HYPH cord-015021-pol2qm74 316 32 sensitized sensitize VBN cord-015021-pol2qm74 316 33 mice mouse NNS cord-015021-pol2qm74 316 34 . . . cord-015021-pol2qm74 317 1 The the DT cord-015021-pol2qm74 317 2 possibility possibility NN cord-015021-pol2qm74 317 3 to to TO cord-015021-pol2qm74 317 4 use use VB cord-015021-pol2qm74 317 5 WNI WNI NNP cord-015021-pol2qm74 317 6 222 222 CD cord-015021-pol2qm74 317 7 - - SYM cord-015021-pol2qm74 317 8 5 5 CD cord-015021-pol2qm74 317 9 as as IN cord-015021-pol2qm74 317 10 a a DT cord-015021-pol2qm74 317 11 capture capture NN cord-015021-pol2qm74 317 12 antibodies antibody NNS cord-015021-pol2qm74 317 13 in in IN cord-015021-pol2qm74 317 14 the the DT cord-015021-pol2qm74 317 15 immunolimulus immunolimulus JJ cord-015021-pol2qm74 317 16 assay assay NN cord-015021-pol2qm74 317 17 opens open VBZ cord-015021-pol2qm74 317 18 the the DT cord-015021-pol2qm74 317 19 possibility possibility NN cord-015021-pol2qm74 317 20 to to TO cord-015021-pol2qm74 317 21 differentiate differentiate VB cord-015021-pol2qm74 317 22 the the DT cord-015021-pol2qm74 317 23 origin origin NN cord-015021-pol2qm74 317 24 of of IN cord-015021-pol2qm74 317 25 the the DT cord-015021-pol2qm74 317 26 LPS LPS NNP cord-015021-pol2qm74 317 27 in in IN cord-015021-pol2qm74 317 28 patients patient NNS cord-015021-pol2qm74 317 29 with with IN cord-015021-pol2qm74 317 30 endotoxemia endotoxemia NN cord-015021-pol2qm74 317 31 . . . cord-015021-pol2qm74 318 1 Franco Franco NNP cord-015021-pol2qm74 318 2 Di Di NNP cord-015021-pol2qm74 318 3 Padova Padova NNP cord-015021-pol2qm74 318 4 , , , cord-015021-pol2qm74 318 5 SANDOZ SANDOZ NNP cord-015021-pol2qm74 318 6 Pharma Pharma NNP cord-015021-pol2qm74 318 7 AG AG NNP cord-015021-pol2qm74 318 8 , , , cord-015021-pol2qm74 318 9 CH4002 CH4002 NNP cord-015021-pol2qm74 318 10 Basel Basel NNP cord-015021-pol2qm74 318 11 , , , cord-015021-pol2qm74 318 12 $ $ $ cord-015021-pol2qm74 318 13 chweiz chweiz NN cord-015021-pol2qm74 318 14 $ $ $ cord-015021-pol2qm74 318 15 7 7 CD cord-015021-pol2qm74 318 16 Presentation Presentation NNP cord-015021-pol2qm74 318 17 of of IN cord-015021-pol2qm74 318 18 LPS LPS NNP cord-015021-pol2qm74 318 19 to to IN cord-015021-pol2qm74 318 20 CD14 CD14 NNP cord-015021-pol2qm74 318 21 by by IN cord-015021-pol2qm74 318 22 LPS LPS NNP cord-015021-pol2qm74 318 23 Binding Binding NNP cord-015021-pol2qm74 318 24 Protein Protein NNP cord-015021-pol2qm74 318 25 Peter Peter NNP cord-015021-pol2qm74 318 26 S. S. NNP cord-015021-pol2qm74 318 27 Tobias Tobias NNP cord-015021-pol2qm74 318 28 , , , cord-015021-pol2qm74 318 29 Julie Julie NNP cord-015021-pol2qm74 318 30 Gegner Gegner NNP cord-015021-pol2qm74 318 31 , , , cord-015021-pol2qm74 318 32 Katrin Katrin NNP cord-015021-pol2qm74 318 33 Soldau Soldau NNP cord-015021-pol2qm74 318 34 , , , cord-015021-pol2qm74 318 35 Lois Lois NNP cord-015021-pol2qm74 318 36 Kline Kline NNP cord-015021-pol2qm74 318 37 , , , cord-015021-pol2qm74 318 38 Loren Loren NNP cord-015021-pol2qm74 318 39 Hatlen Hatlen NNP cord-015021-pol2qm74 318 40 , , , cord-015021-pol2qm74 318 41 Douglas Douglas NNP cord-015021-pol2qm74 318 42 Mintz Mintz NNP cord-015021-pol2qm74 318 43 , , , cord-015021-pol2qm74 318 44 and and CC cord-015021-pol2qm74 318 45 Richard Richard NNP cord-015021-pol2qm74 318 46 J. J. NNP cord-015021-pol2qm74 318 47 Ulevitch Ulevitch NNP cord-015021-pol2qm74 318 48 . . . cord-015021-pol2qm74 319 1 The the DT cord-015021-pol2qm74 319 2 activation activation NN cord-015021-pol2qm74 319 3 of of IN cord-015021-pol2qm74 319 4 myeloid myeloid NN cord-015021-pol2qm74 319 5 cells cell NNS cord-015021-pol2qm74 319 6 by by IN cord-015021-pol2qm74 319 7 lipopolysaccharides lipopolysaccharides NNP cord-015021-pol2qm74 319 8 ( ( -LRB- cord-015021-pol2qm74 319 9 LPS LPS NNP cord-015021-pol2qm74 319 10 ) ) -RRB- cord-015021-pol2qm74 319 11 has have VBZ cord-015021-pol2qm74 319 12 been be VBN cord-015021-pol2qm74 319 13 shown show VBN cord-015021-pol2qm74 319 14 to to TO cord-015021-pol2qm74 319 15 require require VB cord-015021-pol2qm74 319 16 the the DT cord-015021-pol2qm74 319 17 serum serum NN cord-015021-pol2qm74 319 18 glycoprotein glycoprotein NN cord-015021-pol2qm74 319 19 LPS LPS NNP cord-015021-pol2qm74 319 20 binding bind VBG cord-015021-pol2qm74 319 21 protein protein NN cord-015021-pol2qm74 319 22 ( ( -LRB- cord-015021-pol2qm74 319 23 LBP LBP NNP cord-015021-pol2qm74 319 24 ) ) -RRB- cord-015021-pol2qm74 319 25 and and CC cord-015021-pol2qm74 319 26 binding binding NN cord-015021-pol2qm74 319 27 of of IN cord-015021-pol2qm74 319 28 LPS lp NNS cord-015021-pol2qm74 319 29 to to IN cord-015021-pol2qm74 319 30 membrane membrane NN cord-015021-pol2qm74 319 31 bound bind VBN cord-015021-pol2qm74 319 32 CD14 CD14 NNP cord-015021-pol2qm74 319 33 ( ( -LRB- cord-015021-pol2qm74 319 34 mCD14 mCD14 NNP cord-015021-pol2qm74 319 35 ) ) -RRB- cord-015021-pol2qm74 319 36 . . . cord-015021-pol2qm74 320 1 Other other JJ cord-015021-pol2qm74 320 2 cells cell NNS cord-015021-pol2qm74 320 3 such such JJ cord-015021-pol2qm74 320 4 as as IN cord-015021-pol2qm74 320 5 human human JJ cord-015021-pol2qm74 320 6 umbilical umbilical JJ cord-015021-pol2qm74 320 7 vein vein NN cord-015021-pol2qm74 320 8 endothelial endothelial JJ cord-015021-pol2qm74 320 9 cells cell NNS cord-015021-pol2qm74 320 10 ( ( -LRB- cord-015021-pol2qm74 320 11 HUVEC HUVEC NNP cord-015021-pol2qm74 320 12 ) ) -RRB- cord-015021-pol2qm74 320 13 , , , cord-015021-pol2qm74 320 14 smooth smooth JJ cord-015021-pol2qm74 320 15 muscle muscle NN cord-015021-pol2qm74 320 16 cells cell NNS cord-015021-pol2qm74 320 17 , , , cord-015021-pol2qm74 320 18 and and CC cord-015021-pol2qm74 320 19 some some DT cord-015021-pol2qm74 320 20 epithelial epithelial JJ cord-015021-pol2qm74 320 21 cells cell NNS cord-015021-pol2qm74 320 22 , , , cord-015021-pol2qm74 320 23 which which WDT cord-015021-pol2qm74 320 24 do do VBP cord-015021-pol2qm74 320 25 not not RB cord-015021-pol2qm74 320 26 express express VB cord-015021-pol2qm74 320 27 mCD14 mCD14 NNP cord-015021-pol2qm74 320 28 but but CC cord-015021-pol2qm74 320 29 nevertheless nevertheless RB cord-015021-pol2qm74 320 30 respond respond VBZ cord-015021-pol2qm74 320 31 to to IN cord-015021-pol2qm74 320 32 LPS LPS NNP cord-015021-pol2qm74 320 33 in in IN cord-015021-pol2qm74 320 34 the the DT cord-015021-pol2qm74 320 35 presence presence NN cord-015021-pol2qm74 320 36 of of IN cord-015021-pol2qm74 320 37 serum serum NN cord-015021-pol2qm74 320 38 , , , cord-015021-pol2qm74 320 39 have have VBP cord-015021-pol2qm74 320 40 receptors receptor NNS cord-015021-pol2qm74 320 41 for for IN cord-015021-pol2qm74 320 42 complexes complex NNS cord-015021-pol2qm74 320 43 of of IN cord-015021-pol2qm74 320 44 LPS lp NNS cord-015021-pol2qm74 320 45 with with IN cord-015021-pol2qm74 320 46 the the DT cord-015021-pol2qm74 320 47 soluble soluble JJ cord-015021-pol2qm74 320 48 form form NN cord-015021-pol2qm74 320 49 of of IN cord-015021-pol2qm74 320 50 CD14 CD14 NNP cord-015021-pol2qm74 320 51 ( ( -LRB- cord-015021-pol2qm74 320 52 sCD14 sCD14 NNP cord-015021-pol2qm74 320 53 ) ) -RRB- cord-015021-pol2qm74 320 54 . . . cord-015021-pol2qm74 321 1 These these DT cord-015021-pol2qm74 321 2 complexes complex NNS cord-015021-pol2qm74 321 3 of of IN cord-015021-pol2qm74 321 4 LPS LPS NNP cord-015021-pol2qm74 321 5 with with IN cord-015021-pol2qm74 321 6 sCD14 sCD14 NNP cord-015021-pol2qm74 321 7 are be VBP cord-015021-pol2qm74 321 8 only only RB cord-015021-pol2qm74 321 9 formed form VBN cord-015021-pol2qm74 321 10 efficiently efficiently RB cord-015021-pol2qm74 321 11 in in IN cord-015021-pol2qm74 321 12 the the DT cord-015021-pol2qm74 321 13 presence presence NN cord-015021-pol2qm74 321 14 of of IN cord-015021-pol2qm74 321 15 LBP LBP NNP cord-015021-pol2qm74 321 16 . . . cord-015021-pol2qm74 322 1 We -PRON- PRP cord-015021-pol2qm74 322 2 have have VBP cord-015021-pol2qm74 322 3 begun begin VBN cord-015021-pol2qm74 322 4 to to TO cord-015021-pol2qm74 322 5 characterise characterise VB cord-015021-pol2qm74 322 6 the the DT cord-015021-pol2qm74 322 7 mechanisms mechanism NNS cord-015021-pol2qm74 322 8 by by IN cord-015021-pol2qm74 322 9 which which WDT cord-015021-pol2qm74 322 10 LBP LBP NNP cord-015021-pol2qm74 322 11 enables enable VBZ cord-015021-pol2qm74 322 12 LPS lp NNS cord-015021-pol2qm74 322 13 to to TO cord-015021-pol2qm74 322 14 bind bind VB cord-015021-pol2qm74 322 15 to to IN cord-015021-pol2qm74 322 16 CD14 CD14 NNP cord-015021-pol2qm74 322 17 , , , cord-015021-pol2qm74 322 18 either either CC cord-015021-pol2qm74 322 19 soluble soluble JJ cord-015021-pol2qm74 322 20 or or CC cord-015021-pol2qm74 322 21 membrane membrane NN cord-015021-pol2qm74 322 22 bound bind VBN cord-015021-pol2qm74 322 23 . . . cord-015021-pol2qm74 323 1 With with IN cord-015021-pol2qm74 323 2 the the DT cord-015021-pol2qm74 323 3 use use NN cord-015021-pol2qm74 323 4 of of IN cord-015021-pol2qm74 323 5 fluorophore fluorophore NN cord-015021-pol2qm74 323 6 and and CC cord-015021-pol2qm74 323 7 radiolabelled radiolabelled JJ cord-015021-pol2qm74 323 8 reagents reagent NNS cord-015021-pol2qm74 323 9 we -PRON- PRP cord-015021-pol2qm74 323 10 have have VBP cord-015021-pol2qm74 323 11 developed develop VBN cord-015021-pol2qm74 323 12 procedures procedure NNS cord-015021-pol2qm74 323 13 for for IN cord-015021-pol2qm74 323 14 quantitative quantitative JJ cord-015021-pol2qm74 323 15 measurement measurement NN cord-015021-pol2qm74 323 16 of of IN cord-015021-pol2qm74 323 17 the the DT cord-015021-pol2qm74 323 18 association association NN cord-015021-pol2qm74 323 19 of of IN cord-015021-pol2qm74 323 20 LPS LPS NNP cord-015021-pol2qm74 323 21 with with IN cord-015021-pol2qm74 323 22 LBP LBP NNP cord-015021-pol2qm74 323 23 and and CC cord-015021-pol2qm74 323 24 of of IN cord-015021-pol2qm74 323 25 LPS LPS NNP cord-015021-pol2qm74 323 26 - - HYPH cord-015021-pol2qm74 323 27 LBP LBP NNP cord-015021-pol2qm74 323 28 complexes complex NNS cord-015021-pol2qm74 323 29 with with IN cord-015021-pol2qm74 323 30 CD14 CD14 NNP cord-015021-pol2qm74 323 31 . . . cord-015021-pol2qm74 324 1 These these DT cord-015021-pol2qm74 324 2 results result NNS cord-015021-pol2qm74 324 3 show show VBP cord-015021-pol2qm74 324 4 that that IN cord-015021-pol2qm74 324 5 the the DT cord-015021-pol2qm74 324 6 delivery delivery NN cord-015021-pol2qm74 324 7 of of IN cord-015021-pol2qm74 324 8 LPS lp NNS cord-015021-pol2qm74 324 9 to to IN cord-015021-pol2qm74 324 10 sCD14 sCD14 NNP cord-015021-pol2qm74 324 11 is be VBZ cord-015021-pol2qm74 324 12 catalysed catalyse VBN cord-015021-pol2qm74 324 13 by by IN cord-015021-pol2qm74 324 14 LBP LBP NNP cord-015021-pol2qm74 324 15 , , , cord-015021-pol2qm74 324 16 i.e. i.e. FW cord-015021-pol2qm74 324 17 , , , cord-015021-pol2qm74 324 18 LBP LBP NNP cord-015021-pol2qm74 324 19 is be VBZ cord-015021-pol2qm74 324 20 not not RB cord-015021-pol2qm74 324 21 included include VBN cord-015021-pol2qm74 324 22 with with IN cord-015021-pol2qm74 324 23 the the DT cord-015021-pol2qm74 324 24 LPS LPS NNP cord-015021-pol2qm74 324 25 - - HYPH cord-015021-pol2qm74 324 26 sCD14 sCD14 NNP cord-015021-pol2qm74 324 27 complex complex NN cord-015021-pol2qm74 324 28 . . . cord-015021-pol2qm74 325 1 In in IN cord-015021-pol2qm74 325 2 contrast contrast NN cord-015021-pol2qm74 325 3 , , , cord-015021-pol2qm74 325 4 on on IN cord-015021-pol2qm74 325 5 the the DT cord-015021-pol2qm74 325 6 surface surface NN cord-015021-pol2qm74 325 7 of of IN cord-015021-pol2qm74 325 8 cells cell NNS cord-015021-pol2qm74 325 9 , , , cord-015021-pol2qm74 325 10 LBP LBP NNP cord-015021-pol2qm74 325 11 does do VBZ cord-015021-pol2qm74 325 12 not not RB cord-015021-pol2qm74 325 13 dissociate dissociate VB cord-015021-pol2qm74 325 14 from from IN cord-015021-pol2qm74 325 15 the the DT cord-015021-pol2qm74 325 16 cells cell NNS cord-015021-pol2qm74 325 17 after after IN cord-015021-pol2qm74 325 18 LPS LPS NNP cord-015021-pol2qm74 325 19 binds bind VBZ cord-015021-pol2qm74 325 20 to to IN cord-015021-pol2qm74 325 21 mCD14 mCD14 NNP cord-015021-pol2qm74 325 22 . . . cord-015021-pol2qm74 326 1 The the DT cord-015021-pol2qm74 326 2 kinetics kinetic NNS cord-015021-pol2qm74 326 3 , , , cord-015021-pol2qm74 326 4 equilibria equilibrium NNS cord-015021-pol2qm74 326 5 and and CC cord-015021-pol2qm74 326 6 stoichiometry stoichiometry NN cord-015021-pol2qm74 326 7 of of IN cord-015021-pol2qm74 326 8 these these DT cord-015021-pol2qm74 326 9 reactions reaction NNS cord-015021-pol2qm74 326 10 will will MD cord-015021-pol2qm74 326 11 be be VB cord-015021-pol2qm74 326 12 discussed discuss VBN cord-015021-pol2qm74 326 13 in in IN cord-015021-pol2qm74 326 14 the the DT cord-015021-pol2qm74 326 15 context context NN cord-015021-pol2qm74 326 16 of of IN cord-015021-pol2qm74 326 17 models model NNS cord-015021-pol2qm74 326 18 for for IN cord-015021-pol2qm74 326 19 cellular cellular JJ cord-015021-pol2qm74 326 20 activation activation NN cord-015021-pol2qm74 326 21 by by IN cord-015021-pol2qm74 326 22 LPS LPS NNP cord-015021-pol2qm74 326 23 and and CC cord-015021-pol2qm74 326 24 cellular cellular JJ cord-015021-pol2qm74 326 25 uptake uptake NN cord-015021-pol2qm74 326 26 of of IN cord-015021-pol2qm74 326 27 LPS LPS NNP cord-015021-pol2qm74 326 28 . . . cord-015021-pol2qm74 327 1 Supported support VBN cord-015021-pol2qm74 327 2 by by IN cord-015021-pol2qm74 327 3 Nltt Nltt NNP cord-015021-pol2qm74 327 4 grants grant NNS cord-015021-pol2qm74 327 5 GM37696 gm37696 NN cord-015021-pol2qm74 327 6 , , , cord-015021-pol2qm74 327 7 AI32021 ai32021 NN cord-015021-pol2qm74 327 8 , , , cord-015021-pol2qm74 327 9 AI15136 AI15136 NNP cord-015021-pol2qm74 327 10 , , , cord-015021-pol2qm74 327 11 GM08172 GM08172 NNP cord-015021-pol2qm74 327 12 , , , cord-015021-pol2qm74 327 13 and and CC cord-015021-pol2qm74 327 14 assistance assistance NN cord-015021-pol2qm74 327 15 from from IN cord-015021-pol2qm74 327 16 the the DT cord-015021-pol2qm74 327 17 Pharmaceutical Pharmaceutical NNP cord-015021-pol2qm74 327 18 Research Research NNP cord-015021-pol2qm74 327 19 Institute Institute NNP cord-015021-pol2qm74 327 20 of of IN cord-015021-pol2qm74 327 21 Johnson Johnson NNP cord-015021-pol2qm74 327 22 and and CC cord-015021-pol2qm74 327 23 Johnson Johnson NNP cord-015021-pol2qm74 327 24 . . . cord-015021-pol2qm74 328 1 The the DT cord-015021-pol2qm74 328 2 Scripps Scripps NNP cord-015021-pol2qm74 328 3 Research Research NNP cord-015021-pol2qm74 328 4 Institute Institute NNP cord-015021-pol2qm74 328 5 , , , cord-015021-pol2qm74 328 6 IMM-12 imm-12 CD cord-015021-pol2qm74 328 7 , , , cord-015021-pol2qm74 328 8 10666 10666 CD cord-015021-pol2qm74 329 1 N. N. NNP cord-015021-pol2qm74 329 2 Torrey Torrey NNP cord-015021-pol2qm74 329 3 Pines Pines NNP cord-015021-pol2qm74 329 4 Rd Rd NNP cord-015021-pol2qm74 329 5 . . . cord-015021-pol2qm74 329 6 La La NNP cord-015021-pol2qm74 329 7 Jolla Jolla NNP cord-015021-pol2qm74 329 8 , , , cord-015021-pol2qm74 329 9 CA CA NNP cord-015021-pol2qm74 329 10 USA USA NNP cord-015021-pol2qm74 329 11 92037 92037 CD cord-015021-pol2qm74 329 12 . . . cord-015021-pol2qm74 330 1 Modulation modulation NN cord-015021-pol2qm74 330 2 of of IN cord-015021-pol2qm74 330 3 endotoxin endotoxin NN cord-015021-pol2qm74 330 4 - - HYPH cord-015021-pol2qm74 330 5 induced induce VBN cord-015021-pol2qm74 330 6 cytokine cytokine NN cord-015021-pol2qm74 330 7 production production NN cord-015021-pol2qm74 330 8 by by IN cord-015021-pol2qm74 330 9 LPS LPS NNP cord-015021-pol2qm74 330 10 partial partial JJ cord-015021-pol2qm74 330 11 structures structure NNS cord-015021-pol2qm74 330 12 H.-D. H.-D. NNP cord-015021-pol2qm74 330 13 Flad Flad NNP cord-015021-pol2qm74 330 14 , , , cord-015021-pol2qm74 330 15 H. H. NNP cord-015021-pol2qm74 330 16 Loppnow Loppnow NNP cord-015021-pol2qm74 330 17 , , , cord-015021-pol2qm74 330 18 T. T. NNP cord-015021-pol2qm74 330 19 Mattern Mattern NNP cord-015021-pol2qm74 330 20 , , , cord-015021-pol2qm74 330 21 and and CC cord-015021-pol2qm74 330 22 A.J. A.J. NNP cord-015021-pol2qm74 330 23 Ulmer Ulmer NNP cord-015021-pol2qm74 330 24 Department Department NNP cord-015021-pol2qm74 330 25 of of IN cord-015021-pol2qm74 330 26 Immunology Immunology NNP cord-015021-pol2qm74 330 27 and and CC cord-015021-pol2qm74 330 28 Cell Cell NNP cord-015021-pol2qm74 330 29 Biology Biology NNP cord-015021-pol2qm74 330 30 , , , cord-015021-pol2qm74 330 31 Forschungsinstitut Forschungsinstitut NNP cord-015021-pol2qm74 330 32 Borstel Borstel NNP cord-015021-pol2qm74 330 33 , , , cord-015021-pol2qm74 330 34 D-23845 d-23845 NN cord-015021-pol2qm74 331 1 Borstel Borstel NNP cord-015021-pol2qm74 331 2 Lipid Lipid NNP cord-015021-pol2qm74 331 3 A A NNP cord-015021-pol2qm74 331 4 constitutes constitute VBZ cord-015021-pol2qm74 331 5 the the DT cord-015021-pol2qm74 331 6 active active JJ cord-015021-pol2qm74 331 7 moiety moiety NN cord-015021-pol2qm74 331 8 of of IN cord-015021-pol2qm74 331 9 endotoxin endotoxin NN cord-015021-pol2qm74 331 10 ( ( -LRB- cord-015021-pol2qm74 331 11 LPS LPS NNP cord-015021-pol2qm74 331 12 ) ) -RRB- cord-015021-pol2qm74 331 13 of of IN cord-015021-pol2qm74 331 14 Gramnegative Gramnegative NNP cord-015021-pol2qm74 331 15 bacteria bacteria NNS cord-015021-pol2qm74 331 16 . . . cord-015021-pol2qm74 332 1 It -PRON- PRP cord-015021-pol2qm74 332 2 activates activate VBZ cord-015021-pol2qm74 332 3 mononuclear mononuclear JJ cord-015021-pol2qm74 332 4 phagocytes phagocyte NNS cord-015021-pol2qm74 332 5 to to TO cord-015021-pol2qm74 332 6 produce produce VB cord-015021-pol2qm74 332 7 cytokines cytokine NNS cord-015021-pol2qm74 332 8 , , , cord-015021-pol2qm74 332 9 such such JJ cord-015021-pol2qm74 332 10 as as IN cord-015021-pol2qm74 332 11 TNF TNF NNP cord-015021-pol2qm74 332 12 , , , cord-015021-pol2qm74 332 13 I1_-1 I1_-1 NNP cord-015021-pol2qm74 332 14 , , , cord-015021-pol2qm74 332 15 and and CC cord-015021-pol2qm74 332 16 IL-6 IL-6 NNP cord-015021-pol2qm74 332 17 , , , cord-015021-pol2qm74 332 18 which which WDT cord-015021-pol2qm74 332 19 are be VBP cord-015021-pol2qm74 332 20 the the DT cord-015021-pol2qm74 332 21 major major JJ cord-015021-pol2qm74 332 22 mediators mediator NNS cord-015021-pol2qm74 332 23 of of IN cord-015021-pol2qm74 332 24 the the DT cord-015021-pol2qm74 332 25 endotoxic endotoxic JJ cord-015021-pol2qm74 332 26 effect effect NN cord-015021-pol2qm74 332 27 of of IN cord-015021-pol2qm74 332 28 LPS LPS NNP cord-015021-pol2qm74 332 29 in in IN cord-015021-pol2qm74 332 30 vivo vivo NN cord-015021-pol2qm74 332 31 . . . cord-015021-pol2qm74 333 1 Lipid Lipid NNP cord-015021-pol2qm74 333 2 A a DT cord-015021-pol2qm74 333 3 precursor precursor NN cord-015021-pol2qm74 333 4 la la FW cord-015021-pol2qm74 333 5 ( ( -LRB- cord-015021-pol2qm74 333 6 synthetic synthetic JJ cord-015021-pol2qm74 333 7 compound compound NN cord-015021-pol2qm74 333 8 406 406 CD cord-015021-pol2qm74 333 9 ) ) -RRB- cord-015021-pol2qm74 333 10 does do VBZ cord-015021-pol2qm74 333 11 not not RB cord-015021-pol2qm74 333 12 induce induce VB cord-015021-pol2qm74 333 13 cytokines cytokine NNS cord-015021-pol2qm74 333 14 , , , cord-015021-pol2qm74 333 15 but but CC cord-015021-pol2qm74 333 16 is be VBZ cord-015021-pol2qm74 333 17 able able JJ cord-015021-pol2qm74 333 18 to to TO cord-015021-pol2qm74 333 19 specifically specifically RB cord-015021-pol2qm74 333 20 antagonize antagonize VB cord-015021-pol2qm74 333 21 LPS LPS NNP cord-015021-pol2qm74 333 22 - - : cord-015021-pol2qm74 333 23 or or CC cord-015021-pol2qm74 333 24 lipid lipid NN cord-015021-pol2qm74 333 25 A a NN cord-015021-pol2qm74 333 26 - - HYPH cord-015021-pol2qm74 333 27 induced induce VBN cord-015021-pol2qm74 333 28 mediator mediator NN cord-015021-pol2qm74 333 29 production production NN cord-015021-pol2qm74 333 30 in in IN cord-015021-pol2qm74 333 31 human human JJ cord-015021-pol2qm74 333 32 mononuclear mononuclear NN cord-015021-pol2qm74 333 33 cells cell NNS cord-015021-pol2qm74 333 34 , , , cord-015021-pol2qm74 333 35 vascular vascular JJ cord-015021-pol2qm74 333 36 endothelial endothelial JJ cord-015021-pol2qm74 333 37 cells cell NNS cord-015021-pol2qm74 333 38 , , , cord-015021-pol2qm74 333 39 and and CC cord-015021-pol2qm74 333 40 smooth smooth JJ cord-015021-pol2qm74 333 41 muscle muscle NN cord-015021-pol2qm74 333 42 cells cell NNS cord-015021-pol2qm74 333 43 . . . cord-015021-pol2qm74 334 1 Furthermore furthermore RB cord-015021-pol2qm74 334 2 , , , cord-015021-pol2qm74 334 3 we -PRON- PRP cord-015021-pol2qm74 334 4 present present VBP cord-015021-pol2qm74 334 5 evidence evidence NN cord-015021-pol2qm74 334 6 for for IN cord-015021-pol2qm74 334 7 the the DT cord-015021-pol2qm74 334 8 first first JJ cord-015021-pol2qm74 334 9 time time NN cord-015021-pol2qm74 334 10 that that WDT cord-015021-pol2qm74 334 11 T t NN cord-015021-pol2qm74 334 12 - - HYPH cord-015021-pol2qm74 334 13 lymphocytes lymphocyte NNS cord-015021-pol2qm74 334 14 proliferate proliferate VBP cord-015021-pol2qm74 334 15 in in IN cord-015021-pol2qm74 334 16 response response NN cord-015021-pol2qm74 334 17 to to IN cord-015021-pol2qm74 334 18 LPS LPS NNP cord-015021-pol2qm74 334 19 and and CC cord-015021-pol2qm74 334 20 express express VB cord-015021-pol2qm74 334 21 mRNA mrna NN cord-015021-pol2qm74 334 22 for for IN cord-015021-pol2qm74 334 23 interleukin-2 interleukin-2 NNP cord-015021-pol2qm74 334 24 and and CC cord-015021-pol2qm74 334 25 interferon-~ interferon-~ NNP cord-015021-pol2qm74 334 26 and and CC cord-015021-pol2qm74 334 27 that that IN cord-015021-pol2qm74 334 28 these these DT cord-015021-pol2qm74 334 29 responses response NNS cord-015021-pol2qm74 334 30 are be VBP cord-015021-pol2qm74 334 31 also also RB cord-015021-pol2qm74 334 32 antagonized antagonize VBN cord-015021-pol2qm74 334 33 by by IN cord-015021-pol2qm74 334 34 synthetic synthetic JJ cord-015021-pol2qm74 334 35 lipid lipid NN cord-015021-pol2qm74 334 36 A a DT cord-015021-pol2qm74 334 37 precursor precursor NN cord-015021-pol2qm74 334 38 la la NN cord-015021-pol2qm74 334 39 . . . cord-015021-pol2qm74 335 1 When when WRB cord-015021-pol2qm74 335 2 comparing compare VBG cord-015021-pol2qm74 335 3 the the DT cord-015021-pol2qm74 335 4 agonistic agonistic JJ cord-015021-pol2qm74 335 5 and and CC cord-015021-pol2qm74 335 6 antagonistic antagonistic JJ cord-015021-pol2qm74 335 7 activity activity NN cord-015021-pol2qm74 335 8 of of IN cord-015021-pol2qm74 335 9 lipid lipid NN cord-015021-pol2qm74 335 10 A a NN cord-015021-pol2qm74 335 11 and and CC cord-015021-pol2qm74 335 12 different different JJ cord-015021-pol2qm74 335 13 partial partial JJ cord-015021-pol2qm74 335 14 structures structure NNS cord-015021-pol2qm74 335 15 at at IN cord-015021-pol2qm74 335 16 the the DT cord-015021-pol2qm74 335 17 functional functional JJ cord-015021-pol2qm74 335 18 and and CC cord-015021-pol2qm74 335 19 binding binding JJ cord-015021-pol2qm74 335 20 level level NN cord-015021-pol2qm74 335 21 , , , cord-015021-pol2qm74 335 22 the the DT cord-015021-pol2qm74 335 23 number number NN cord-015021-pol2qm74 335 24 and and CC cord-015021-pol2qm74 335 25 length length NN cord-015021-pol2qm74 335 26 of of IN cord-015021-pol2qm74 335 27 the the DT cord-015021-pol2qm74 335 28 fatty fatty JJ cord-015021-pol2qm74 335 29 acids acid NNS cord-015021-pol2qm74 335 30 and and CC cord-015021-pol2qm74 335 31 the the DT cord-015021-pol2qm74 335 32 number number NN cord-015021-pol2qm74 335 33 of of IN cord-015021-pol2qm74 335 34 phosphoryl phosphoryl NNP cord-015021-pol2qm74 335 35 groups group NNS cord-015021-pol2qm74 335 36 were be VBD cord-015021-pol2qm74 335 37 Pound pound NN cord-015021-pol2qm74 335 38 to to TO cord-015021-pol2qm74 335 39 be be VB cord-015021-pol2qm74 335 40 of of IN cord-015021-pol2qm74 335 41 crucial crucial JJ cord-015021-pol2qm74 335 42 importance importance NN cord-015021-pol2qm74 335 43 . . . cord-015021-pol2qm74 336 1 Unexpectedly unexpectedly RB cord-015021-pol2qm74 336 2 , , , cord-015021-pol2qm74 336 3 lipid lipid VBG cord-015021-pol2qm74 336 4 A a DT cord-015021-pol2qm74 336 5 precursor precursor NN cord-015021-pol2qm74 336 6 la la NN cord-015021-pol2qm74 336 7 , , , cord-015021-pol2qm74 336 8 although although IN cord-015021-pol2qm74 336 9 biologically biologically RB cord-015021-pol2qm74 336 10 inactive inactive JJ cord-015021-pol2qm74 336 11 , , , cord-015021-pol2qm74 336 12 turned turn VBD cord-015021-pol2qm74 336 13 out out RP cord-015021-pol2qm74 336 14 to to TO cord-015021-pol2qm74 336 15 be be VB cord-015021-pol2qm74 336 16 both both CC cord-015021-pol2qm74 336 17 the the DT cord-015021-pol2qm74 336 18 most most RBS cord-015021-pol2qm74 336 19 potent potent JJ cord-015021-pol2qm74 336 20 antagonist antagonist NN cord-015021-pol2qm74 336 21 and and CC cord-015021-pol2qm74 336 22 competitor competitor NN cord-015021-pol2qm74 336 23 in in IN cord-015021-pol2qm74 336 24 inhibiting inhibit VBG cord-015021-pol2qm74 336 25 the the DT cord-015021-pol2qm74 336 26 binding binding NN cord-015021-pol2qm74 336 27 of of IN cord-015021-pol2qm74 336 28 LPS lp NNS cord-015021-pol2qm74 336 29 . . . cord-015021-pol2qm74 337 1 Taken take VBN cord-015021-pol2qm74 337 2 together together RB cord-015021-pol2qm74 337 3 , , , cord-015021-pol2qm74 337 4 our -PRON- PRP$ cord-015021-pol2qm74 337 5 results result NNS cord-015021-pol2qm74 337 6 provide provide VBP cord-015021-pol2qm74 337 7 evidence evidence NN cord-015021-pol2qm74 337 8 for for IN cord-015021-pol2qm74 337 9 a a DT cord-015021-pol2qm74 337 10 model model NN cord-015021-pol2qm74 337 11 in in IN cord-015021-pol2qm74 337 12 which which WDT cord-015021-pol2qm74 337 13 lipid lipid NN cord-015021-pol2qm74 337 14 A a DT cord-015021-pol2qm74 337 15 partial partial JJ cord-015021-pol2qm74 337 16 structures structure NNS cord-015021-pol2qm74 337 17 compete compete VBP cord-015021-pol2qm74 337 18 with with IN cord-015021-pol2qm74 337 19 LPS lp NNS cord-015021-pol2qm74 337 20 for for IN cord-015021-pol2qm74 337 21 specific specific JJ cord-015021-pol2qm74 337 22 cell cell NN cord-015021-pol2qm74 337 23 surface surface NN cord-015021-pol2qm74 337 24 receptor(s receptor(s NNP cord-015021-pol2qm74 337 25 ) ) -RRB- cord-015021-pol2qm74 337 26 . . . cord-015021-pol2qm74 338 1 In in IN cord-015021-pol2qm74 338 2 this this DT cord-015021-pol2qm74 338 3 sense sense NN cord-015021-pol2qm74 338 4 , , , cord-015021-pol2qm74 338 5 biologically biologically RB cord-015021-pol2qm74 338 6 inactive inactive JJ cord-015021-pol2qm74 338 7 lipid lipid NN cord-015021-pol2qm74 338 8 A a DT cord-015021-pol2qm74 338 9 analogues analogue NNS cord-015021-pol2qm74 338 10 may may MD cord-015021-pol2qm74 338 11 be be VB cord-015021-pol2qm74 338 12 good good JJ cord-015021-pol2qm74 338 13 candidates candidate NNS cord-015021-pol2qm74 338 14 as as IN cord-015021-pol2qm74 338 15 therapeutic therapeutic JJ cord-015021-pol2qm74 338 16 agents agent NNS cord-015021-pol2qm74 338 17 for for IN cord-015021-pol2qm74 338 18 the the DT cord-015021-pol2qm74 338 19 prevention prevention NN cord-015021-pol2qm74 338 20 of of IN cord-015021-pol2qm74 338 21 Gram gram NN cord-015021-pol2qm74 338 22 - - HYPH cord-015021-pol2qm74 338 23 negative negative JJ cord-015021-pol2qm74 338 24 septic septic JJ cord-015021-pol2qm74 338 25 shock shock NN cord-015021-pol2qm74 338 26 . . . cord-015021-pol2qm74 339 1 Two two CD cord-015021-pol2qm74 339 2 mammalian mammalian JJ cord-015021-pol2qm74 339 3 lipid lipid NN cord-015021-pol2qm74 339 4 A a NN cord-015021-pol2qm74 339 5 - - HYPH cord-015021-pol2qm74 339 6 binding bind VBG cord-015021-pol2qm74 339 7 proteins protein NNS cord-015021-pol2qm74 339 8 have have VBP cord-015021-pol2qm74 339 9 been be VBN cord-015021-pol2qm74 339 10 identified identify VBN cord-015021-pol2qm74 339 11 that that WDT cord-015021-pol2qm74 339 12 are be VBP cord-015021-pol2qm74 339 13 believed believe VBN cord-015021-pol2qm74 339 14 to to TO cord-015021-pol2qm74 339 15 have have VB cord-015021-pol2qm74 339 16 important important JJ cord-015021-pol2qm74 339 17 roles role NNS cord-015021-pol2qm74 339 18 in in IN cord-015021-pol2qm74 339 19 mediating mediate VBG cord-015021-pol2qm74 339 20 the the DT cord-015021-pol2qm74 339 21 host host NN cord-015021-pol2qm74 339 22 response response NN cord-015021-pol2qm74 339 23 to to IN cord-015021-pol2qm74 339 24 endotoxin endotoxin NN cord-015021-pol2qm74 339 25 : : : cord-015021-pol2qm74 339 26 lipopolysaccharide lipopolysaccharide NN cord-015021-pol2qm74 339 27 - - HYPH cord-015021-pol2qm74 339 28 binding bind VBG cord-015021-pol2qm74 339 29 protein protein NN cord-015021-pol2qm74 339 30 ( ( -LRB- cord-015021-pol2qm74 339 31 LBP LBP NNP cord-015021-pol2qm74 339 32 ) ) -RRB- cord-015021-pol2qm74 339 33 and and CC cord-015021-pol2qm74 339 34 bactericidal/ bactericidal/ CD cord-015021-pol2qm74 339 35 permeability permeability NN cord-015021-pol2qm74 339 36 - - HYPH cord-015021-pol2qm74 339 37 increasing increase VBG cord-015021-pol2qm74 339 38 protein protein NN cord-015021-pol2qm74 339 39 ( ( -LRB- cord-015021-pol2qm74 339 40 BPI BPI NNP cord-015021-pol2qm74 339 41 ) ) -RRB- cord-015021-pol2qm74 339 42 . . . cord-015021-pol2qm74 340 1 Human human JJ cord-015021-pol2qm74 340 2 LBP LBP NNP cord-015021-pol2qm74 340 3 shares share VBZ cord-015021-pol2qm74 340 4 a a DT cord-015021-pol2qm74 340 5 45 45 CD cord-015021-pol2qm74 340 6 % % NN cord-015021-pol2qm74 340 7 amino amino NN cord-015021-pol2qm74 340 8 acid acid NN cord-015021-pol2qm74 340 9 sequence sequence NN cord-015021-pol2qm74 340 10 identity identity NN cord-015021-pol2qm74 340 11 with with IN cord-015021-pol2qm74 340 12 human human JJ cord-015021-pol2qm74 340 13 BPI BPI NNP cord-015021-pol2qm74 340 14 . . . cord-015021-pol2qm74 341 1 Despite despite IN cord-015021-pol2qm74 341 2 the the DT cord-015021-pol2qm74 341 3 sequence sequence NN cord-015021-pol2qm74 341 4 homology homology NN cord-015021-pol2qm74 341 5 , , , cord-015021-pol2qm74 341 6 the the DT cord-015021-pol2qm74 341 7 two two CD cord-015021-pol2qm74 341 8 lipid lipid NN cord-015021-pol2qm74 341 9 A a NN cord-015021-pol2qm74 341 10 - - HYPH cord-015021-pol2qm74 341 11 binding bind VBG cord-015021-pol2qm74 341 12 proteins protein NNS cord-015021-pol2qm74 341 13 have have VBP cord-015021-pol2qm74 341 14 very very RB cord-015021-pol2qm74 341 15 different different JJ cord-015021-pol2qm74 341 16 functional functional JJ cord-015021-pol2qm74 341 17 activities activity NNS cord-015021-pol2qm74 341 18 . . . cord-015021-pol2qm74 342 1 LBP LBP NNP cord-015021-pol2qm74 342 2 is be VBZ cord-015021-pol2qm74 342 3 an an DT cord-015021-pol2qm74 342 4 acute acute JJ cord-015021-pol2qm74 342 5 phase phase NN cord-015021-pol2qm74 342 6 serum serum NN cord-015021-pol2qm74 342 7 protein protein NN cord-015021-pol2qm74 342 8 that that WDT cord-015021-pol2qm74 342 9 markedly markedly RB cord-015021-pol2qm74 342 10 potentiates potentiate VBZ cord-015021-pol2qm74 342 11 the the DT cord-015021-pol2qm74 342 12 proinfiammatory proinfiammatory NNP cord-015021-pol2qm74 342 13 host host NN cord-015021-pol2qm74 342 14 response response NN cord-015021-pol2qm74 342 15 to to IN cord-015021-pol2qm74 342 16 gram gram JJ cord-015021-pol2qm74 342 17 - - HYPH cord-015021-pol2qm74 342 18 negative negative JJ cord-015021-pol2qm74 342 19 infection infection NN cord-015021-pol2qm74 342 20 by by IN cord-015021-pol2qm74 342 21 a a DT cord-015021-pol2qm74 342 22 mechanism mechanism NN cord-015021-pol2qm74 342 23 which which WDT cord-015021-pol2qm74 342 24 involves involve VBZ cord-015021-pol2qm74 342 25 binding binding NN cord-015021-pol2qm74 342 26 of of IN cord-015021-pol2qm74 342 27 the the DT cord-015021-pol2qm74 342 28 LBP LBP NNP cord-015021-pol2qm74 342 29 - - HYPH cord-015021-pol2qm74 342 30 LPS LPS NNP cord-015021-pol2qm74 342 31 complex complex NN cord-015021-pol2qm74 342 32 to to IN cord-015021-pol2qm74 342 33 CD14 CD14 NNP cord-015021-pol2qm74 342 34 receptors receptor NNS cord-015021-pol2qm74 342 35 on on IN cord-015021-pol2qm74 342 36 monocytes monocyte NNS cord-015021-pol2qm74 342 37 , , , cord-015021-pol2qm74 342 38 neutrophils neutrophil NNS cord-015021-pol2qm74 342 39 and and CC cord-015021-pol2qm74 342 40 endothelial endothelial JJ cord-015021-pol2qm74 342 41 cells cell NNS cord-015021-pol2qm74 342 42 . . . cord-015021-pol2qm74 343 1 In in IN cord-015021-pol2qm74 343 2 contrast contrast NN cord-015021-pol2qm74 343 3 , , , cord-015021-pol2qm74 343 4 BPI BPI NNP cord-015021-pol2qm74 343 5 is be VBZ cord-015021-pol2qm74 343 6 a a DT cord-015021-pol2qm74 343 7 neutrophil neutrophil NN cord-015021-pol2qm74 343 8 granule granule NN cord-015021-pol2qm74 343 9 protein protein NN cord-015021-pol2qm74 343 10 with with IN cord-015021-pol2qm74 343 11 potent potent JJ cord-015021-pol2qm74 343 12 bactericidal bactericidal JJ cord-015021-pol2qm74 343 13 and and CC cord-015021-pol2qm74 343 14 LPS lps NN cord-015021-pol2qm74 343 15 - - HYPH cord-015021-pol2qm74 343 16 neutralizing neutralize VBG cord-015021-pol2qm74 343 17 activities activity NNS cord-015021-pol2qm74 343 18 . . . cord-015021-pol2qm74 344 1 The the DT cord-015021-pol2qm74 344 2 divergent divergent JJ cord-015021-pol2qm74 344 3 functional functional JJ cord-015021-pol2qm74 344 4 properties property NNS cord-015021-pol2qm74 344 5 of of IN cord-015021-pol2qm74 344 6 these these DT cord-015021-pol2qm74 344 7 two two CD cord-015021-pol2qm74 344 8 LPS LPS NNP cord-015021-pol2qm74 344 9 - - HYPH cord-015021-pol2qm74 344 10 bindlng bindlng NN cord-015021-pol2qm74 344 11 proteins protein NNS cord-015021-pol2qm74 344 12 can can MD cord-015021-pol2qm74 344 13 be be VB cord-015021-pol2qm74 344 14 explained explain VBN cord-015021-pol2qm74 344 15 by by IN cord-015021-pol2qm74 344 16 the the DT cord-015021-pol2qm74 344 17 inability inability NN cord-015021-pol2qm74 344 18 of of IN cord-015021-pol2qm74 344 19 BPI BPI NNP cord-015021-pol2qm74 344 20 - - HYPH cord-015021-pol2qm74 344 21 LPS LPS NNP cord-015021-pol2qm74 344 22 complexes complex NNS cord-015021-pol2qm74 344 23 to to TO cord-015021-pol2qm74 344 24 bind bind VB cord-015021-pol2qm74 344 25 to to IN cord-015021-pol2qm74 344 26 cell cell NN cord-015021-pol2qm74 344 27 - - HYPH cord-015021-pol2qm74 344 28 surface surface NN cord-015021-pol2qm74 344 29 CD14 CD14 NNP cord-015021-pol2qm74 344 30 receptors receptor NNS cord-015021-pol2qm74 344 31 . . . cord-015021-pol2qm74 345 1 A a DT cord-015021-pol2qm74 345 2 recombinant recombinant JJ cord-015021-pol2qm74 345 3 protein protein NN cord-015021-pol2qm74 345 4 ( ( -LRB- cord-015021-pol2qm74 345 5 rBPI23 rBPI23 NNP cord-015021-pol2qm74 345 6 ) ) -RRB- cord-015021-pol2qm74 345 7 , , , cord-015021-pol2qm74 345 8 corresponding correspond VBG cord-015021-pol2qm74 345 9 to to IN cord-015021-pol2qm74 345 10 the the DT cord-015021-pol2qm74 345 11 amino amino NN cord-015021-pol2qm74 345 12 terminal terminal NN cord-015021-pol2qm74 345 13 23kD 23kd CD cord-015021-pol2qm74 345 14 fragment fragment NN cord-015021-pol2qm74 345 15 of of IN cord-015021-pol2qm74 345 16 human human JJ cord-015021-pol2qm74 345 17 BPI BPI NNP cord-015021-pol2qm74 345 18 , , , cord-015021-pol2qm74 345 19 has have VBZ cord-015021-pol2qm74 345 20 been be VBN cord-015021-pol2qm74 345 21 shown show VBN cord-015021-pol2qm74 345 22 to to TO cord-015021-pol2qm74 345 23 retain retain VB cord-015021-pol2qm74 345 24 the the DT cord-015021-pol2qm74 345 25 potent potent JJ cord-015021-pol2qm74 345 26 biological biological JJ cord-015021-pol2qm74 345 27 activities activity NNS cord-015021-pol2qm74 345 28 of of IN cord-015021-pol2qm74 345 29 the the DT cord-015021-pol2qm74 345 30 hdlo hdlo NN cord-015021-pol2qm74 345 31 protein protein NN cord-015021-pol2qm74 345 32 and and CC cord-015021-pol2qm74 345 33 may may MD cord-015021-pol2qm74 345 34 represent represent VB cord-015021-pol2qm74 345 35 a a DT cord-015021-pol2qm74 345 36 novel novel JJ cord-015021-pol2qm74 345 37 therapeutic therapeutic JJ cord-015021-pol2qm74 345 38 agent agent NN cord-015021-pol2qm74 345 39 for for IN cord-015021-pol2qm74 345 40 the the DT cord-015021-pol2qm74 345 41 treatment treatment NN cord-015021-pol2qm74 345 42 of of IN cord-015021-pol2qm74 345 43 gram gram NN cord-015021-pol2qm74 345 44 - - HYPH cord-015021-pol2qm74 345 45 negative negative JJ cord-015021-pol2qm74 345 46 infections infection NNS cord-015021-pol2qm74 345 47 , , , cord-015021-pol2qm74 345 48 sepsis sepsis NN cord-015021-pol2qm74 345 49 and and CC cord-015021-pol2qm74 345 50 endotoxemia endotoxemia NN cord-015021-pol2qm74 345 51 . . . cord-015021-pol2qm74 346 1 For for IN cord-015021-pol2qm74 346 2 therapeutic therapeutic JJ cord-015021-pol2qm74 346 3 effectiveness effectiveness NN cord-015021-pol2qm74 346 4 in in IN cord-015021-pol2qm74 346 5 many many JJ cord-015021-pol2qm74 346 6 clinical clinical JJ cord-015021-pol2qm74 346 7 situations situation NNS cord-015021-pol2qm74 346 8 , , , cord-015021-pol2qm74 346 9 rBPI23 rBPI23 NNP cord-015021-pol2qm74 346 10 will will MD cord-015021-pol2qm74 346 11 have have VB cord-015021-pol2qm74 346 12 to to TO cord-015021-pol2qm74 346 13 successfully successfully RB cord-015021-pol2qm74 346 14 compete compete VB cord-015021-pol2qm74 346 15 with with IN cord-015021-pol2qm74 346 16 relatively relatively RB cord-015021-pol2qm74 346 17 high high JJ cord-015021-pol2qm74 346 18 serum serum NN cord-015021-pol2qm74 346 19 levels level NNS cord-015021-pol2qm74 346 20 of of IN cord-015021-pol2qm74 346 21 LBP LBP NNP cord-015021-pol2qm74 346 22 ( ( -LRB- cord-015021-pol2qm74 346 23 5 5 CD cord-015021-pol2qm74 346 24 - - SYM cord-015021-pol2qm74 346 25 60 60 CD cord-015021-pol2qm74 346 26 ~g ~g NNP cord-015021-pol2qm74 346 27 / / SYM cord-015021-pol2qm74 346 28 mI mI NNP cord-015021-pol2qm74 346 29 ) ) -RRB- cord-015021-pol2qm74 346 30 for for IN cord-015021-pol2qm74 346 31 binding bind VBG cord-015021-pol2qm74 346 32 to to IN cord-015021-pol2qm74 346 33 endotoxin endotoxin NN cord-015021-pol2qm74 346 34 and and CC cord-015021-pol2qm74 346 35 gram gram NN cord-015021-pol2qm74 346 36 - - HYPH cord-015021-pol2qm74 346 37 negative negative JJ cord-015021-pol2qm74 346 38 bacteria bacteria NNS cord-015021-pol2qm74 346 39 . . . cord-015021-pol2qm74 347 1 To to TO cord-015021-pol2qm74 347 2 evaluate evaluate VB cord-015021-pol2qm74 347 3 this this DT cord-015021-pol2qm74 347 4 issue issue NN cord-015021-pol2qm74 347 5 , , , cord-015021-pol2qm74 347 6 experiments experiment NNS cord-015021-pol2qm74 347 7 were be VBD cord-015021-pol2qm74 347 8 conducted conduct VBN cord-015021-pol2qm74 347 9 to to TO cord-015021-pol2qm74 347 10 compare compare VB cord-015021-pol2qm74 347 11 the the DT cord-015021-pol2qm74 347 12 relative relative JJ cord-015021-pol2qm74 347 13 binding bind VBG cord-015021-pol2qm74 347 14 affinities affinity NNS cord-015021-pol2qm74 347 15 of of IN cord-015021-pol2qm74 347 16 rBPI23 rBPI23 NNP cord-015021-pol2qm74 347 17 and and CC cord-015021-pol2qm74 347 18 human human JJ cord-015021-pol2qm74 347 19 recombinant recombinant JJ cord-015021-pol2qm74 347 20 LBP LBP NNP cord-015021-pol2qm74 347 21 ( ( -LRB- cord-015021-pol2qm74 347 22 rLBP rlbp IN cord-015021-pol2qm74 347 23 ) ) -RRB- cord-015021-pol2qm74 347 24 for for IN cord-015021-pol2qm74 347 25 lipid lipid NN cord-015021-pol2qm74 347 26 A. a. NN cord-015021-pol2qm74 348 1 The the DT cord-015021-pol2qm74 348 2 binding binding NN cord-015021-pol2qm74 348 3 of of IN cord-015021-pol2qm74 348 4 both both DT cord-015021-pol2qm74 348 5 proteins protein NNS cord-015021-pol2qm74 348 6 to to IN cord-015021-pol2qm74 348 7 Iipid Iipid NNP cord-015021-pol2qm74 348 8 A A NNP cord-015021-pol2qm74 348 9 was be VBD cord-015021-pol2qm74 348 10 specific specific JJ cord-015021-pol2qm74 348 11 and and CC cord-015021-pol2qm74 348 12 saturable saturable JJ cord-015021-pol2qm74 348 13 with with IN cord-015021-pol2qm74 348 14 apparent apparent JJ cord-015021-pol2qm74 349 1 Kd Kd NNP cord-015021-pol2qm74 349 2 'S 'S NNP cord-015021-pol2qm74 349 3 of of IN cord-015021-pol2qm74 349 4 2.6 2.6 CD cord-015021-pol2qm74 349 5 nM nm CD cord-015021-pol2qm74 349 6 for for IN cord-015021-pol2qm74 349 7 rBPI23 rBPI23 NNP cord-015021-pol2qm74 349 8 and and CC cord-015021-pol2qm74 349 9 58 58 CD cord-015021-pol2qm74 349 10 nM nm NN cord-015021-pol2qm74 349 11 for for IN cord-015021-pol2qm74 349 12 rLBP rlbp NN cord-015021-pol2qm74 349 13 . . . cord-015021-pol2qm74 350 1 In in IN cord-015021-pol2qm74 350 2 a a DT cord-015021-pol2qm74 350 3 competition competition NN cord-015021-pol2qm74 350 4 assay assay NN cord-015021-pol2qm74 350 5 format format NN cord-015021-pol2qm74 350 6 rBPI23 rBPI23 NNP cord-015021-pol2qm74 350 7 was be VBD cord-015021-pol2qm74 350 8 approximately approximately RB cord-015021-pol2qm74 350 9 75-fold 75-fold CD cord-015021-pol2qm74 350 10 more more RBR cord-015021-pol2qm74 350 11 potent potent JJ cord-015021-pol2qm74 350 12 than than IN cord-015021-pol2qm74 350 13 rLBP rlbp JJ cord-015021-pol2qm74 350 14 in in IN cord-015021-pol2qm74 350 15 inhibiting inhibit VBG cord-015021-pol2qm74 350 16 the the DT cord-015021-pol2qm74 350 17 binding binding NN cord-015021-pol2qm74 350 18 of of IN cord-015021-pol2qm74 350 19 nSI nSI NNP cord-015021-pol2qm74 350 20 - - HYPH cord-015021-pol2qm74 350 21 rLBP rlbp NN cord-015021-pol2qm74 350 22 to to IN cord-015021-pol2qm74 350 23 lipid lipid NN cord-015021-pol2qm74 350 24 A. a. NN cord-015021-pol2qm74 351 1 These these DT cord-015021-pol2qm74 351 2 results result NNS cord-015021-pol2qm74 351 3 demonstrate demonstrate VBP cord-015021-pol2qm74 351 4 that that IN cord-015021-pol2qm74 351 5 rBPI23 rBPI23 NNP cord-015021-pol2qm74 351 6 has have VBZ cord-015021-pol2qm74 351 7 a a DT cord-015021-pol2qm74 351 8 significantly significantly RB cord-015021-pol2qm74 351 9 higher high JJR cord-015021-pol2qm74 351 10 affinity affinity NN cord-015021-pol2qm74 351 11 for for IN cord-015021-pol2qm74 351 12 endotoxin endotoxin NN cord-015021-pol2qm74 351 13 than than IN cord-015021-pol2qm74 351 14 does do VBZ cord-015021-pol2qm74 351 15 rLBP rlbp NN cord-015021-pol2qm74 351 16 and and CC cord-015021-pol2qm74 351 17 may may MD cord-015021-pol2qm74 351 18 explain explain VB cord-015021-pol2qm74 351 19 the the DT cord-015021-pol2qm74 351 20 potent potent JJ cord-015021-pol2qm74 351 21 inhibitory inhibitory JJ cord-015021-pol2qm74 351 22 activity activity NN cord-015021-pol2qm74 351 23 of of IN cord-015021-pol2qm74 351 24 low low JJ cord-015021-pol2qm74 351 25 concentrations concentration NNS cord-015021-pol2qm74 351 26 of of IN cord-015021-pol2qm74 351 27 rBPI23 rBPI23 NNP cord-015021-pol2qm74 351 28 in in IN cord-015021-pol2qm74 351 29 a a DT cord-015021-pol2qm74 351 30 variety variety NN cord-015021-pol2qm74 351 31 of of IN cord-015021-pol2qm74 351 32 in in FW cord-015021-pol2qm74 351 33 vitro vitro FW cord-015021-pol2qm74 351 34 functional functional JJ cord-015021-pol2qm74 351 35 assays assay NNS cord-015021-pol2qm74 351 36 for for IN cord-015021-pol2qm74 351 37 LPS LPS NNP cord-015021-pol2qm74 351 38 activation activation NN cord-015021-pol2qm74 351 39 of of IN cord-015021-pol2qm74 351 40 cells cell NNS cord-015021-pol2qm74 351 41 despite despite IN cord-015021-pol2qm74 351 42 the the DT cord-015021-pol2qm74 351 43 presence presence NN cord-015021-pol2qm74 351 44 of of IN cord-015021-pol2qm74 351 45 high high JJ cord-015021-pol2qm74 351 46 LBP LBP NNP cord-015021-pol2qm74 351 47 levels level NNS cord-015021-pol2qm74 351 48 . . . cord-015021-pol2qm74 352 1 For for IN cord-015021-pol2qm74 352 2 example example NN cord-015021-pol2qm74 352 3 , , , cord-015021-pol2qm74 352 4 rBPI23 rBPI23 NNP cord-015021-pol2qm74 352 5 at at IN cord-015021-pol2qm74 352 6 0.2 0.2 CD cord-015021-pol2qm74 353 1 ~tg ~tg NNP cord-015021-pol2qm74 353 2 / / SYM cord-015021-pol2qm74 353 3 mi mi NNP cord-015021-pol2qm74 353 4 was be VBD cord-015021-pol2qm74 353 5 able able JJ cord-015021-pol2qm74 353 6 to to TO cord-015021-pol2qm74 353 7 totally totally RB cord-015021-pol2qm74 353 8 inhibit inhibit VB cord-015021-pol2qm74 353 9 LPS LPS NNP cord-015021-pol2qm74 353 10 - - HYPH cord-015021-pol2qm74 353 11 induced induce VBN cord-015021-pol2qm74 353 12 TNF TNF NNP cord-015021-pol2qm74 353 13 release release NN cord-015021-pol2qm74 353 14 from from IN cord-015021-pol2qm74 353 15 monocytes monocyte NNS cord-015021-pol2qm74 353 16 despite despite IN cord-015021-pol2qm74 353 17 a a DT cord-015021-pol2qm74 353 18 100-fold 100-fold CD cord-015021-pol2qm74 353 19 weight weight NN cord-015021-pol2qm74 353 20 excess excess NN cord-015021-pol2qm74 353 21 of of IN cord-015021-pol2qm74 353 22 rLBP rlbp NN cord-015021-pol2qm74 353 23 over over IN cord-015021-pol2qm74 353 24 rBPI23 rBPI23 NNP cord-015021-pol2qm74 353 25 . . . cord-015021-pol2qm74 354 1 and and CC cord-015021-pol2qm74 354 2 for for IN cord-015021-pol2qm74 354 3 heparin heparin NN cord-015021-pol2qm74 354 4 binding binding NN cord-015021-pol2qm74 354 5 . . . cord-015021-pol2qm74 355 1 Three three CD cord-015021-pol2qm74 355 2 separate separate JJ cord-015021-pol2qm74 355 3 domains domain NNS cord-015021-pol2qm74 355 4 which which WDT cord-015021-pol2qm74 355 5 inhibit inhibit VBP cord-015021-pol2qm74 355 6 the the DT cord-015021-pol2qm74 355 7 LAL LAL NNP cord-015021-pol2qm74 355 8 reaction reaction NN cord-015021-pol2qm74 355 9 to to IN cord-015021-pol2qm74 355 10 LPS LPS NNP cord-015021-pol2qm74 355 11 and and CC cord-015021-pol2qm74 355 12 bind bind VB cord-015021-pol2qm74 355 13 to to IN cord-015021-pol2qm74 355 14 heparin heparin NN cord-015021-pol2qm74 355 15 were be VBD cord-015021-pol2qm74 355 16 identified identify VBN cord-015021-pol2qm74 355 17 in in IN cord-015021-pol2qm74 355 18 amino amino JJ cord-015021-pol2qm74 355 19 acid acid NN cord-015021-pol2qm74 355 20 regions region NNS cord-015021-pol2qm74 355 21 17 17 CD cord-015021-pol2qm74 355 22 - - SYM cord-015021-pol2qm74 355 23 45 45 CD cord-015021-pol2qm74 355 24 , , , cord-015021-pol2qm74 355 25 65 65 CD cord-015021-pol2qm74 355 26 - - SYM cord-015021-pol2qm74 355 27 99 99 CD cord-015021-pol2qm74 355 28 and and CC cord-015021-pol2qm74 355 29 142 142 CD cord-015021-pol2qm74 355 30 - - SYM cord-015021-pol2qm74 355 31 169 169 CD cord-015021-pol2qm74 355 32 . . . cord-015021-pol2qm74 356 1 A a DT cord-015021-pol2qm74 356 2 single single JJ cord-015021-pol2qm74 356 3 synthetic synthetic JJ cord-015021-pol2qm74 356 4 peptide peptide NN cord-015021-pol2qm74 356 5 ( ( -LRB- cord-015021-pol2qm74 356 6 85 85 CD cord-015021-pol2qm74 356 7 - - SYM cord-015021-pol2qm74 356 8 99 99 CD cord-015021-pol2qm74 356 9 ) ) -RRB- cord-015021-pol2qm74 356 10 was be VBD cord-015021-pol2qm74 356 11 bactericidal bactericidal JJ cord-015021-pol2qm74 356 12 . . . cord-015021-pol2qm74 357 1 These these DT cord-015021-pol2qm74 357 2 results result NNS cord-015021-pol2qm74 357 3 suggest suggest VBP cord-015021-pol2qm74 357 4 that that IN cord-015021-pol2qm74 357 5 rBPI23 rBPI23 NNP cord-015021-pol2qm74 357 6 contains contain VBZ cord-015021-pol2qm74 357 7 three three CD cord-015021-pol2qm74 357 8 separate separate JJ cord-015021-pol2qm74 357 9 functional functional JJ cord-015021-pol2qm74 357 10 domains domain NNS cord-015021-pol2qm74 357 11 which which WDT cord-015021-pol2qm74 357 12 may may MD cord-015021-pol2qm74 357 13 contribute contribute VB cord-015021-pol2qm74 357 14 to to IN cord-015021-pol2qm74 357 15 its -PRON- PRP$ cord-015021-pol2qm74 357 16 high high JJ cord-015021-pol2qm74 357 17 affmity affmity NN cord-015021-pol2qm74 357 18 interaction interaction NN cord-015021-pol2qm74 357 19 with with IN cord-015021-pol2qm74 357 20 Gram gram NN cord-015021-pol2qm74 357 21 - - HYPH cord-015021-pol2qm74 357 22 negative negative JJ cord-015021-pol2qm74 357 23 bacteria bacteria NNS cord-015021-pol2qm74 357 24 and and CC cord-015021-pol2qm74 357 25 heparin heparin NN cord-015021-pol2qm74 357 26 . . . cord-015021-pol2qm74 358 1 The the DT cord-015021-pol2qm74 358 2 individual individual JJ cord-015021-pol2qm74 358 3 activity activity NN cord-015021-pol2qm74 358 4 of of IN cord-015021-pol2qm74 358 5 each each DT cord-015021-pol2qm74 358 6 domain domain NN cord-015021-pol2qm74 358 7 and and CC cord-015021-pol2qm74 358 8 the the DT cord-015021-pol2qm74 358 9 cooperative cooperative JJ cord-015021-pol2qm74 358 10 interaction interaction NN cord-015021-pol2qm74 358 11 among among IN cord-015021-pol2qm74 358 12 domains domain NNS cord-015021-pol2qm74 358 13 provide provide VBP cord-015021-pol2qm74 358 14 the the DT cord-015021-pol2qm74 358 15 basis basis NN cord-015021-pol2qm74 358 16 for for IN cord-015021-pol2qm74 358 17 developing develop VBG cord-015021-pol2qm74 358 18 rBPI23 rBPI23 NNP cord-015021-pol2qm74 358 19 analogues analogue NNS cord-015021-pol2qm74 358 20 with with IN cord-015021-pol2qm74 358 21 increased increase VBN cord-015021-pol2qm74 358 22 biologic biologic JJ cord-015021-pol2qm74 358 23 efficacy efficacy NN cord-015021-pol2qm74 358 24 . . . cord-015021-pol2qm74 359 1 A a DT cord-015021-pol2qm74 359 2 considerable considerable JJ cord-015021-pol2qm74 359 3 body body NN cord-015021-pol2qm74 359 4 of of IN cord-015021-pol2qm74 359 5 experimental experimental JJ cord-015021-pol2qm74 359 6 data datum NNS cord-015021-pol2qm74 359 7 has have VBZ cord-015021-pol2qm74 359 8 accumulated accumulate VBN cord-015021-pol2qm74 359 9 implicating implicate VBG cord-015021-pol2qm74 359 10 tumour tumour NN cord-015021-pol2qm74 359 11 necrosis necrosis NN cord-015021-pol2qm74 359 12 factor factor NN cord-015021-pol2qm74 359 13 ( ( -LRB- cord-015021-pol2qm74 359 14 TNF TNF NNP cord-015021-pol2qm74 359 15 ) ) -RRB- cord-015021-pol2qm74 359 16 as as IN cord-015021-pol2qm74 359 17 a a DT cord-015021-pol2qm74 359 18 principal principal JJ cord-015021-pol2qm74 359 19 mediator mediator NN cord-015021-pol2qm74 359 20 of of IN cord-015021-pol2qm74 359 21 the the DT cord-015021-pol2qm74 359 22 pathophysiological pathophysiological JJ cord-015021-pol2qm74 359 23 features feature NNS cord-015021-pol2qm74 359 24 of of IN cord-015021-pol2qm74 359 25 septic septic JJ cord-015021-pol2qm74 359 26 shock shock NN cord-015021-pol2qm74 359 27 . . . cord-015021-pol2qm74 360 1 These these DT cord-015021-pol2qm74 360 2 data datum NNS cord-015021-pol2qm74 360 3 prompted prompt VBD cord-015021-pol2qm74 360 4 the the DT cord-015021-pol2qm74 360 5 development development NN cord-015021-pol2qm74 360 6 of of IN cord-015021-pol2qm74 360 7 clinical clinical JJ cord-015021-pol2qm74 360 8 strategies strategy NNS cord-015021-pol2qm74 360 9 designed design VBN cord-015021-pol2qm74 360 10 to to TO cord-015021-pol2qm74 360 11 limit limit VB cord-015021-pol2qm74 360 12 excess excess JJ cord-015021-pol2qm74 360 13 ( ( -LRB- cord-015021-pol2qm74 360 14 inappropriate inappropriate JJ cord-015021-pol2qm74 360 15 ) ) -RRB- cord-015021-pol2qm74 360 16 TNF tnf NN cord-015021-pol2qm74 360 17 production production NN cord-015021-pol2qm74 360 18 . . . cord-015021-pol2qm74 361 1 Monoclonoal Monoclonoal NNP cord-015021-pol2qm74 361 2 antibodies antibody NNS cord-015021-pol2qm74 361 3 ( ( -LRB- cord-015021-pol2qm74 361 4 Mobs mob NNS cord-015021-pol2qm74 361 5 ) ) -RRB- cord-015021-pol2qm74 361 6 were be VBD cord-015021-pol2qm74 361 7 developed develop VBN cord-015021-pol2qm74 361 8 and and CC cord-015021-pol2qm74 361 9 a a DT cord-015021-pol2qm74 361 10 phase phase NN cord-015021-pol2qm74 361 11 II ii CD cord-015021-pol2qm74 362 1 dose dose JJ cord-015021-pol2qm74 362 2 escalation escalation NN cord-015021-pol2qm74 362 3 trial trial NN cord-015021-pol2qm74 362 4 in in IN cord-015021-pol2qm74 362 5 80 80 CD cord-015021-pol2qm74 362 6 patients patient NNS cord-015021-pol2qm74 362 7 confirmed confirm VBD cord-015021-pol2qm74 362 8 that that IN cord-015021-pol2qm74 362 9 the the DT cord-015021-pol2qm74 362 10 Mab Mab NNP cord-015021-pol2qm74 362 11 was be VBD cord-015021-pol2qm74 362 12 safe safe JJ cord-015021-pol2qm74 362 13 , , , cord-015021-pol2qm74 362 14 and and CC cord-015021-pol2qm74 362 15 suggested suggest VBD cord-015021-pol2qm74 362 16 that that IN cord-015021-pol2qm74 362 17 it -PRON- PRP cord-015021-pol2qm74 362 18 was be VBD cord-015021-pol2qm74 362 19 having have VBG cord-015021-pol2qm74 362 20 a a DT cord-015021-pol2qm74 362 21 beneficial beneficial JJ cord-015021-pol2qm74 362 22 effect effect NN cord-015021-pol2qm74 362 23 on on IN cord-015021-pol2qm74 362 24 certain certain JJ cord-015021-pol2qm74 362 25 parameters parameter NNS cord-015021-pol2qm74 362 26 . . . cord-015021-pol2qm74 363 1 Preliminary preliminary JJ cord-015021-pol2qm74 363 2 results result NNS cord-015021-pol2qm74 363 3 of of IN cord-015021-pol2qm74 363 4 a a DT cord-015021-pol2qm74 363 5 large large JJ cord-015021-pol2qm74 363 6 phase phase NN cord-015021-pol2qm74 363 7 III iii CD cord-015021-pol2qm74 363 8 study study NN cord-015021-pol2qm74 363 9 indicated indicate VBD cord-015021-pol2qm74 363 10 that that IN cord-015021-pol2qm74 363 11 ( ( -LRB- cord-015021-pol2qm74 363 12 a a LS cord-015021-pol2qm74 363 13 ) ) -RRB- cord-015021-pol2qm74 363 14 the the DT cord-015021-pol2qm74 363 15 Mob Mob NNP cord-015021-pol2qm74 363 16 was be VBD cord-015021-pol2qm74 363 17 safe safe JJ cord-015021-pol2qm74 363 18 ; ; : cord-015021-pol2qm74 363 19 ( ( -LRB- cord-015021-pol2qm74 363 20 b b NN cord-015021-pol2qm74 363 21 ) ) -RRB- cord-015021-pol2qm74 363 22 that that IN cord-015021-pol2qm74 363 23 it -PRON- PRP cord-015021-pol2qm74 363 24 was be VBD cord-015021-pol2qm74 363 25 of of IN cord-015021-pol2qm74 363 26 no no DT cord-015021-pol2qm74 363 27 discernible discernible JJ cord-015021-pol2qm74 363 28 benefit benefit NN cord-015021-pol2qm74 363 29 in in IN cord-015021-pol2qm74 363 30 non non JJ cord-015021-pol2qm74 363 31 - - JJ cord-015021-pol2qm74 363 32 shocked shocked JJ cord-015021-pol2qm74 363 33 patients patient NNS cord-015021-pol2qm74 363 34 ; ; , cord-015021-pol2qm74 363 35 ( ( -LRB- cord-015021-pol2qm74 363 36 c c NN cord-015021-pol2qm74 363 37 ) ) -RRB- cord-015021-pol2qm74 363 38 that that IN cord-015021-pol2qm74 363 39 it -PRON- PRP cord-015021-pol2qm74 363 40 reduced reduce VBD cord-015021-pol2qm74 363 41 mortality mortality NN cord-015021-pol2qm74 363 42 in in IN cord-015021-pol2qm74 363 43 shocked shocked JJ cord-015021-pol2qm74 363 44 patients patient NNS cord-015021-pol2qm74 363 45 , , , cord-015021-pol2qm74 363 46 especially especially RB cord-015021-pol2qm74 363 47 during during IN cord-015021-pol2qm74 363 48 the the DT cord-015021-pol2qm74 363 49 first first JJ cord-015021-pol2qm74 363 50 3 3 CD cord-015021-pol2qm74 363 51 days day NNS cord-015021-pol2qm74 363 52 . . . cord-015021-pol2qm74 364 1 An an DT cord-015021-pol2qm74 364 2 alternative alternative JJ cord-015021-pol2qm74 364 3 strategy strategy NN cord-015021-pol2qm74 364 4 was be VBD cord-015021-pol2qm74 364 5 to to TO cord-015021-pol2qm74 364 6 take take VB cord-015021-pol2qm74 364 7 advantage advantage NN cord-015021-pol2qm74 364 8 of of IN cord-015021-pol2qm74 364 9 the the DT cord-015021-pol2qm74 364 10 high high JJ cord-015021-pol2qm74 364 11 binding bind VBG cord-015021-pol2qm74 364 12 affinity affinity NN cord-015021-pol2qm74 364 13 of of IN cord-015021-pol2qm74 364 14 soluble soluble JJ cord-015021-pol2qm74 364 15 receptors receptor NNS cord-015021-pol2qm74 364 16 for for IN cord-015021-pol2qm74 364 17 TNF TNF NNP cord-015021-pol2qm74 364 18 ( ( -LRB- cord-015021-pol2qm74 364 19 sTNFR sTNFR NNP cord-015021-pol2qm74 364 20 ) ) -RRB- cord-015021-pol2qm74 364 21 . . . cord-015021-pol2qm74 365 1 sTNFR sTNFR NNP cord-015021-pol2qm74 365 2 - - HYPH cord-015021-pol2qm74 365 3 IgGFc iggfc NN cord-015021-pol2qm74 365 4 constructs construct NNS cord-015021-pol2qm74 365 5 were be VBD cord-015021-pol2qm74 365 6 made make VBN cord-015021-pol2qm74 365 7 for for IN cord-015021-pol2qm74 365 8 both both CC cord-015021-pol2qm74 365 9 the the DT cord-015021-pol2qm74 365 10 p55 p55 NN cord-015021-pol2qm74 365 11 and and CC cord-015021-pol2qm74 365 12 p75 p75 NN cord-015021-pol2qm74 365 13 receptors receptor NNS cord-015021-pol2qm74 365 14 . . . cord-015021-pol2qm74 366 1 Both both DT cord-015021-pol2qm74 366 2 were be VBD cord-015021-pol2qm74 366 3 effective effective JJ cord-015021-pol2qm74 366 4 in in IN cord-015021-pol2qm74 366 5 animal animal NN cord-015021-pol2qm74 366 6 models model NNS cord-015021-pol2qm74 366 7 of of IN cord-015021-pol2qm74 366 8 LPS LPS NNP cord-015021-pol2qm74 366 9 challenge challenge NN cord-015021-pol2qm74 366 10 , , , cord-015021-pol2qm74 366 11 but but CC cord-015021-pol2qm74 366 12 when when WRB cord-015021-pol2qm74 366 13 a a DT cord-015021-pol2qm74 366 14 clinical clinical JJ cord-015021-pol2qm74 366 15 trial trial NN cord-015021-pol2qm74 366 16 was be VBD cord-015021-pol2qm74 366 17 done do VBN cord-015021-pol2qm74 366 18 with with IN cord-015021-pol2qm74 366 19 the the DT cord-015021-pol2qm74 366 20 p75 p75 NNP cord-015021-pol2qm74 366 21 sTNFR stnfr NN cord-015021-pol2qm74 366 22 - - HYPH cord-015021-pol2qm74 366 23 Fc Fc NNP cord-015021-pol2qm74 367 1 there there EX cord-015021-pol2qm74 367 2 was be VBD cord-015021-pol2qm74 367 3 unexpected unexpected JJ cord-015021-pol2qm74 367 4 mortality mortality NN cord-015021-pol2qm74 367 5 in in IN cord-015021-pol2qm74 367 6 the the DT cord-015021-pol2qm74 367 7 treated treated JJ cord-015021-pol2qm74 367 8 arm arm NN cord-015021-pol2qm74 367 9 . . . cord-015021-pol2qm74 368 1 Using use VBG cord-015021-pol2qm74 368 2 an an DT cord-015021-pol2qm74 368 3 animal animal NN cord-015021-pol2qm74 368 4 model model NN cord-015021-pol2qm74 368 5 of of IN cord-015021-pol2qm74 368 6 live live JJ cord-015021-pol2qm74 368 7 E.coli e.coli NN cord-015021-pol2qm74 368 8 sepsis sepsis NN cord-015021-pol2qm74 368 9 , , , cord-015021-pol2qm74 368 10 we -PRON- PRP cord-015021-pol2qm74 368 11 have have VBP cord-015021-pol2qm74 368 12 shown show VBN cord-015021-pol2qm74 368 13 that that IN cord-015021-pol2qm74 368 14 this this DT cord-015021-pol2qm74 368 15 may may MD cord-015021-pol2qm74 368 16 have have VB cord-015021-pol2qm74 368 17 been be VBN cord-015021-pol2qm74 368 18 due due JJ cord-015021-pol2qm74 368 19 to to IN cord-015021-pol2qm74 368 20 the the DT cord-015021-pol2qm74 368 21 release release NN cord-015021-pol2qm74 368 22 of of IN cord-015021-pol2qm74 368 23 bound bind VBN cord-015021-pol2qm74 368 24 TNF TNF NNP cord-015021-pol2qm74 368 25 from from IN cord-015021-pol2qm74 368 26 the the DT cord-015021-pol2qm74 368 27 construct construct NN cord-015021-pol2qm74 368 28 . . . cord-015021-pol2qm74 369 1 Plasma plasma NN cord-015021-pol2qm74 369 2 enhances enhance VBZ cord-015021-pol2qm74 369 3 while while IN cord-015021-pol2qm74 369 4 BPI BPI NNP cord-015021-pol2qm74 369 5 inhibits inhibit VBZ cord-015021-pol2qm74 369 6 LPS LPS NNP cord-015021-pol2qm74 369 7 - - HYPH cord-015021-pol2qm74 369 8 induced induce VBN cord-015021-pol2qm74 369 9 cytokine cytokine NN cord-015021-pol2qm74 369 10 production production NN cord-015021-pol2qm74 369 11 from from IN cord-015021-pol2qm74 369 12 peripheral peripheral JJ cord-015021-pol2qm74 369 13 blood blood NN cord-015021-pol2qm74 369 14 mononuclear mononuclear NN cord-015021-pol2qm74 369 15 cells cell NNS cord-015021-pol2qm74 369 16 ( ( -LRB- cord-015021-pol2qm74 369 17 PBMC PBMC NNP cord-015021-pol2qm74 369 18 ) ) -RRB- cord-015021-pol2qm74 369 19 . . . cord-015021-pol2qm74 370 1 Pseudomonas Pseudomonas NNP cord-015021-pol2qm74 370 2 species specie NNS cord-015021-pol2qm74 370 3 produce produce VBP cord-015021-pol2qm74 370 4 cytokine cytokine NN cord-015021-pol2qm74 370 5 - - HYPH cord-015021-pol2qm74 370 6 inducing induce VBG cord-015021-pol2qm74 370 7 substances substance NNS cord-015021-pol2qm74 370 8 which which WDT cord-015021-pol2qm74 370 9 are be VBP cord-015021-pol2qm74 370 10 different different JJ cord-015021-pol2qm74 370 11 from from IN cord-015021-pol2qm74 370 12 LPS LPS NNP cord-015021-pol2qm74 370 13 as as IN cord-015021-pol2qm74 370 14 indicated indicate VBN cord-015021-pol2qm74 370 15 by by IN cord-015021-pol2qm74 370 16 the the DT cord-015021-pol2qm74 370 17 fact fact NN cord-015021-pol2qm74 370 18 that that IN cord-015021-pol2qm74 370 19 polymyxin polymyxin NN cord-015021-pol2qm74 370 20 B B NNP cord-015021-pol2qm74 370 21 blocks block VBZ cord-015021-pol2qm74 370 22 only only RB cord-015021-pol2qm74 370 23 40 40 CD cord-015021-pol2qm74 370 24 % % NN cord-015021-pol2qm74 370 25 of of IN cord-015021-pol2qm74 370 26 the the DT cord-015021-pol2qm74 370 27 cytokine cytokine NN cord-015021-pol2qm74 370 28 - - HYPH cord-015021-pol2qm74 370 29 inducing induce VBG cord-015021-pol2qm74 370 30 activity activity NN cord-015021-pol2qm74 370 31 of of IN cord-015021-pol2qm74 370 32 these these DT cord-015021-pol2qm74 370 33 pyrogens pyrogen NNS cord-015021-pol2qm74 370 34 . . . cord-015021-pol2qm74 371 1 We -PRON- PRP cord-015021-pol2qm74 371 2 now now RB cord-015021-pol2qm74 371 3 tested test VBD cord-015021-pol2qm74 371 4 the the DT cord-015021-pol2qm74 371 5 effect effect NN cord-015021-pol2qm74 371 6 of of IN cord-015021-pol2qm74 371 7 plasma plasma NN cord-015021-pol2qm74 371 8 and and CC cord-015021-pol2qm74 371 9 BPI BPI NNP cord-015021-pol2qm74 371 10 on on IN cord-015021-pol2qm74 371 11 the the DT cord-015021-pol2qm74 371 12 IL-1[3-inducing il-1[3-inducing NN cord-015021-pol2qm74 371 13 activity activity NN cord-015021-pol2qm74 371 14 of of IN cord-015021-pol2qm74 371 15 Pseudomonas Pseudomonas NNP cord-015021-pol2qm74 371 16 maltophilia maltophilia NNP cord-015021-pol2qm74 371 17 -derived -derived SYM cord-015021-pol2qm74 371 18 pyrogens pyrogens NNP cord-015021-pol2qm74 371 19 ( ( -LRB- cord-015021-pol2qm74 371 20 Pmp Pmp NNP cord-015021-pol2qm74 371 21 ) ) -RRB- cord-015021-pol2qm74 371 22 . . . cord-015021-pol2qm74 372 1 Bacteria Bacteria NNS cord-015021-pol2qm74 372 2 were be VBD cord-015021-pol2qm74 372 3 cultured culture VBN cord-015021-pol2qm74 372 4 to to IN cord-015021-pol2qm74 372 5 the the DT cord-015021-pol2qm74 372 6 log log NN cord-015021-pol2qm74 372 7 phase phase NN cord-015021-pol2qm74 372 8 and and CC cord-015021-pol2qm74 372 9 filtered filter VBN cord-015021-pol2qm74 372 10 ( ( -LRB- cord-015021-pol2qm74 372 11 300kD 300kd NN cord-015021-pol2qm74 372 12 ) ) -RRB- cord-015021-pol2qm74 372 13 to to TO cord-015021-pol2qm74 372 14 obtain obtain VB cord-015021-pol2qm74 372 15 Prop Prop NNP cord-015021-pol2qm74 372 16 . . . cord-015021-pol2qm74 373 1 Dilutions dilution NNS cord-015021-pol2qm74 373 2 of of IN cord-015021-pol2qm74 373 3 Pmp Pmp NNP cord-015021-pol2qm74 373 4 or or CC cord-015021-pol2qm74 373 5 LPS LPS NNP cord-015021-pol2qm74 373 6 were be VBD cord-015021-pol2qm74 373 7 added add VBN cord-015021-pol2qm74 373 8 to to IN cord-015021-pol2qm74 373 9 PBMC PBMC NNP cord-015021-pol2qm74 373 10 alone alone RB cord-015021-pol2qm74 373 11 or or CC cord-015021-pol2qm74 373 12 to to IN cord-015021-pol2qm74 373 13 PBMC PBMC NNP cord-015021-pol2qm74 373 14 in in IN cord-015021-pol2qm74 373 15 5 5 CD cord-015021-pol2qm74 373 16 % % NN cord-015021-pol2qm74 373 17 plasma plasma NN cord-015021-pol2qm74 373 18 + + CC cord-015021-pol2qm74 374 1 /-BPI /-BPI NNP cord-015021-pol2qm74 374 2 ( ( -LRB- cord-015021-pol2qm74 374 3 500 500 CD cord-015021-pol2qm74 374 4 ng ng NN cord-015021-pol2qm74 374 5 / / SYM cord-015021-pol2qm74 374 6 ml ml NN cord-015021-pol2qm74 374 7 ) ) -RRB- cord-015021-pol2qm74 374 8 . . . cord-015021-pol2qm74 375 1 PBMC PBMC NNS cord-015021-pol2qm74 375 2 were be VBD cord-015021-pol2qm74 375 3 incubated incubate VBN cord-015021-pol2qm74 375 4 for for IN cord-015021-pol2qm74 375 5 24 24 CD cord-015021-pol2qm74 375 6 hours hour NNS cord-015021-pol2qm74 375 7 at at IN cord-015021-pol2qm74 375 8 37 37 CD cord-015021-pol2qm74 375 9 ° ° NN cord-015021-pol2qm74 375 10 C c NN cord-015021-pol2qm74 375 11 and and CC cord-015021-pol2qm74 375 12 total total JJ cord-015021-pol2qm74 375 13 IL IL NNP cord-015021-pol2qm74 375 14 - - HYPH cord-015021-pol2qm74 375 15 I~ I~ NNP cord-015021-pol2qm74 375 16 was be VBD cord-015021-pol2qm74 375 17 measured measure VBN cord-015021-pol2qm74 375 18 by by IN cord-015021-pol2qm74 375 19 RIA RIA NNP cord-015021-pol2qm74 375 20 . . . cord-015021-pol2qm74 376 1 Results result NNS cord-015021-pol2qm74 376 2 : : : cord-015021-pol2qm74 377 1 IL IL NNP cord-015021-pol2qm74 377 2 - - HYPH cord-015021-pol2qm74 377 3 I[~ I[~ NNP cord-015021-pol2qm74 377 4 in in IN cord-015021-pol2qm74 377 5 ng ng NNP cord-015021-pol2qm74 377 6 / / SYM cord-015021-pol2qm74 377 7 ml ml NN cord-015021-pol2qm74 378 1 ( ( -LRB- cord-015021-pol2qm74 378 2 n=7 n=7 NNS cord-015021-pol2qm74 378 3 , , , cord-015021-pol2qm74 378 4 mear~+SEM mear~+sem UH cord-015021-pol2qm74 378 5 , , , cord-015021-pol2qm74 379 1 * * NFP cord-015021-pol2qm74 379 2 p<0.05 p<0.05 NNP cord-015021-pol2qm74 379 3 vs vs IN cord-015021-pol2qm74 379 4 control control NN cord-015021-pol2qm74 379 5 ) ) -RRB- cord-015021-pol2qm74 379 6 . . . cord-015021-pol2qm74 379 7 0 0 NFP cord-015021-pol2qm74 380 1 control control NNP cord-015021-pol2qm74 380 2 0.1_+0 0.1_+0 CD cord-015021-pol2qm74 380 3 + + CC cord-015021-pol2qm74 380 4 BPI BPI NNP cord-015021-pol2qm74 380 5 0.1 0.1 CD cord-015021-pol2qm74 380 6 + + SYM cord-015021-pol2qm74 380 7 0 0 CD cord-015021-pol2qm74 380 8 5 5 CD cord-015021-pol2qm74 380 9 % % NN cord-015021-pol2qm74 380 10 plas plas NNP cord-015021-pol2qm74 380 11 . . . cord-015021-pol2qm74 381 1 0.2_+0 0.2_+0 NNP cord-015021-pol2qm74 381 2 + + CC cord-015021-pol2qm74 382 1 BPI BPI NNP cord-015021-pol2qm74 382 2 0.2_+0 0.2_+0 NNP cord-015021-pol2qm74 382 3 Pmp Pmp NNP cord-015021-pol2qm74 382 4 ( ( -LRB- cord-015021-pol2qm74 382 5 ng ng NNP cord-015021-pol2qm74 382 6 / / SYM cord-015021-pol2qm74 382 7 ml ml NN cord-015021-pol2qm74 382 8 ) ) -RRB- cord-015021-pol2qm74 382 9 LPS LPS NNP cord-015021-pol2qm74 382 10 ( ( -LRB- cord-015021-pol2qm74 382 11 ng ng NNP cord-015021-pol2qm74 382 12 / / SYM cord-015021-pol2qm74 382 13 ml ml NN cord-015021-pol2qm74 382 14 ) ) -RRB- cord-015021-pol2qm74 383 1 60 60 CD cord-015021-pol2qm74 383 2 600 600 CD cord-015021-pol2qm74 383 3 3000 3000 CD cord-015021-pol2qm74 383 4 1 1 CD cord-015021-pol2qm74 383 5 10 10 CD cord-015021-pol2qm74 383 6 3.2_+1 3.2_+1 CD cord-015021-pol2qm74 383 7 8.0_+1 8.0_+1 CD cord-015021-pol2qm74 384 1 16.3_+3 16.3_+3 CD cord-015021-pol2qm74 384 2 1.2_+ 1.2_+ NN cord-015021-pol2qm74 384 3 . . . cord-015021-pol2qm74 385 1 2 2 LS cord-015021-pol2qm74 386 1 5.2+.6 5.2+.6 CD cord-015021-pol2qm74 386 2 0.2_+.1 0.2_+.1 CD cord-015021-pol2qm74 387 1 3.3_+.9 3.3_+.9 CD cord-015021-pol2qm74 387 2 " " `` cord-015021-pol2qm74 387 3 13_+3 13_+3 CD cord-015021-pol2qm74 387 4 " " '' cord-015021-pol2qm74 387 5 0.1_+0 0.1_+0 NNP cord-015021-pol2qm74 387 6 " " '' cord-015021-pol2qm74 387 7 0.1_+0 0.1_+0 CD cord-015021-pol2qm74 387 8 " " '' cord-015021-pol2qm74 388 1 2.2_+ 2.2_+ UH cord-015021-pol2qm74 388 2 . . . cord-015021-pol2qm74 389 1 5 5 CD cord-015021-pol2qm74 389 2 5.7 5.7 CD cord-015021-pol2qm74 389 3 + + SYM cord-015021-pol2qm74 389 4 1 1 CD cord-015021-pol2qm74 389 5 14_+2 14_+2 CD cord-015021-pol2qm74 390 1 5_+.6 5_+.6 LS cord-015021-pol2qm74 390 2 * * NFP cord-015021-pol2qm74 390 3 14_+2 14_+2 CD cord-015021-pol2qm74 390 4 " " `` cord-015021-pol2qm74 390 5 0.6 0.6 CD cord-015021-pol2qm74 391 1 + + CC cord-015021-pol2qm74 391 2 . . NN cord-015021-pol2qm74 391 3 4 4 CD cord-015021-pol2qm74 391 4 " " `` cord-015021-pol2qm74 391 5 5.3 5.3 CD cord-015021-pol2qm74 391 6 + + SYM cord-015021-pol2qm74 391 7 1 1 CD cord-015021-pol2qm74 392 1 15-+2 15-+2 CD cord-015021-pol2qm74 392 2 0.1-+0 0.1-+0 CD cord-015021-pol2qm74 392 3 " " `` cord-015021-pol2qm74 392 4 0.5_+.3 0.5_+.3 NNP cord-015021-pol2qm74 392 5 " " '' cord-015021-pol2qm74 392 6 CBA CBA NNP cord-015021-pol2qm74 392 7 , , , cord-015021-pol2qm74 392 8 C57BL/6 C57BL/6 NNP cord-015021-pol2qm74 392 9 , , , cord-015021-pol2qm74 392 10 BALB BALB NNP cord-015021-pol2qm74 392 11 / / SYM cord-015021-pol2qm74 392 12 C C NNP cord-015021-pol2qm74 392 13 , , , cord-015021-pol2qm74 392 14 AKR AKR NNP cord-015021-pol2qm74 392 15 , , , cord-015021-pol2qm74 392 16 DBA DBA NNP cord-015021-pol2qm74 392 17 , , , cord-015021-pol2qm74 392 18 Swiss swiss JJ cord-015021-pol2qm74 392 19 mice mouse NNS cord-015021-pol2qm74 392 20 , , , cord-015021-pol2qm74 392 21 guinea guinea NN cord-015021-pol2qm74 392 22 pigs pig NNS cord-015021-pol2qm74 392 23 , , , cord-015021-pol2qm74 392 24 rabbits rabbit NNS cord-015021-pol2qm74 392 25 have have VBP cord-015021-pol2qm74 392 26 been be VBN cord-015021-pol2qm74 392 27 used use VBN cord-015021-pol2qm74 392 28 in in IN cord-015021-pol2qm74 392 29 research research NN cord-015021-pol2qm74 392 30 work work NN cord-015021-pol2qm74 392 31 . . . cord-015021-pol2qm74 393 1 The the DT cord-015021-pol2qm74 393 2 toxicity toxicity NN cord-015021-pol2qm74 393 3 , , , cord-015021-pol2qm74 393 4 immunogenicity immunogenicity NN cord-015021-pol2qm74 393 5 , , , cord-015021-pol2qm74 393 6 mitogenic mitogenic NNP cord-015021-pol2qm74 393 7 and and CC cord-015021-pol2qm74 393 8 immunomodulating immunomodulating JJ cord-015021-pol2qm74 393 9 activity activity NN cord-015021-pol2qm74 393 10 of of IN cord-015021-pol2qm74 393 11 LPS lp NNS cord-015021-pol2qm74 393 12 have have VBP cord-015021-pol2qm74 393 13 been be VBN cord-015021-pol2qm74 393 14 studied study VBN cord-015021-pol2qm74 393 15 . . . cord-015021-pol2qm74 394 1 The the DT cord-015021-pol2qm74 394 2 possibility possibility NN cord-015021-pol2qm74 394 3 of of IN cord-015021-pol2qm74 394 4 reduction reduction NN cord-015021-pol2qm74 394 5 of of IN cord-015021-pol2qm74 394 6 the the DT cord-015021-pol2qm74 394 7 toxic toxic JJ cord-015021-pol2qm74 394 8 activity activity NN cord-015021-pol2qm74 394 9 of of IN cord-015021-pol2qm74 394 10 LPS LPS NNP cord-015021-pol2qm74 394 11 on on IN cord-015021-pol2qm74 394 12 macroorganism macroorganism NNP cord-015021-pol2qm74 394 13 by by IN cord-015021-pol2qm74 394 14 bioglycansimmunomodulators bioglycansimmunomodulator NNS cord-015021-pol2qm74 394 15 obtained obtain VBN cord-015021-pol2qm74 394 16 from from IN cord-015021-pol2qm74 394 17 sea sea NN cord-015021-pol2qm74 394 18 invertebrates invertebrate NNS cord-015021-pol2qm74 394 19 anymals anymal NNS cord-015021-pol2qm74 394 20 ( ( -LRB- cord-015021-pol2qm74 394 21 Crenomytilus Crenomytilus NNP cord-015021-pol2qm74 394 22 grayanus grayanus NNP cord-015021-pol2qm74 394 23 , , , cord-015021-pol2qm74 394 24 Stromhus Stromhus NNP cord-015021-pol2qm74 394 25 gigas gigas NNP cord-015021-pol2qm74 394 26 ) ) -RRB- cord-015021-pol2qm74 394 27 have have VBP cord-015021-pol2qm74 394 28 been be VBN cord-015021-pol2qm74 394 29 investigated investigate VBN cord-015021-pol2qm74 394 30 too too RB cord-015021-pol2qm74 394 31 . . . cord-015021-pol2qm74 395 1 LPS LPS NNP cord-015021-pol2qm74 395 2 has have VBZ cord-015021-pol2qm74 395 3 been be VBN cord-015021-pol2qm74 395 4 shown show VBN cord-015021-pol2qm74 395 5 to to TO cord-015021-pol2qm74 395 6 induce induce VB cord-015021-pol2qm74 395 7 specific specific JJ cord-015021-pol2qm74 395 8 antibody antibody NN cord-015021-pol2qm74 395 9 response response NN cord-015021-pol2qm74 395 10 of of IN cord-015021-pol2qm74 395 11 laboratory laboratory NN cord-015021-pol2qm74 395 12 animals animal NNS cord-015021-pol2qm74 395 13 . . . cord-015021-pol2qm74 396 1 CBA CBA NNP cord-015021-pol2qm74 396 2 mice mouse NNS cord-015021-pol2qm74 396 3 are be VBP cord-015021-pol2qm74 396 4 high high JJ cord-015021-pol2qm74 396 5 responsive responsive JJ cord-015021-pol2qm74 396 6 to to IN cord-015021-pol2qm74 396 7 LPS LPS NNP cord-015021-pol2qm74 396 8 . . . cord-015021-pol2qm74 397 1 LPS LPS NNP cord-015021-pol2qm74 397 2 stimulates stimulate VBZ cord-015021-pol2qm74 397 3 humoral humoral JJ cord-015021-pol2qm74 397 4 immune immune JJ cord-015021-pol2qm74 397 5 response response NN cord-015021-pol2qm74 397 6 of of IN cord-015021-pol2qm74 397 7 mice mouse NNS cord-015021-pol2qm74 397 8 to to IN cord-015021-pol2qm74 397 9 Tdependent Tdependent NNP cord-015021-pol2qm74 397 10 and and CC cord-015021-pol2qm74 397 11 T T NNP cord-015021-pol2qm74 397 12 - - HYPH cord-015021-pol2qm74 397 13 independent independent JJ cord-015021-pol2qm74 397 14 antigens antigen NNS cord-015021-pol2qm74 397 15 and and CC cord-015021-pol2qm74 397 16 suppresses suppress VBZ cord-015021-pol2qm74 397 17 intensity intensity NN cord-015021-pol2qm74 397 18 of of IN cord-015021-pol2qm74 397 19 the the DT cord-015021-pol2qm74 397 20 delayed delay VBN cord-015021-pol2qm74 397 21 hypersensitivity hypersensitivity NN cord-015021-pol2qm74 397 22 . . . cord-015021-pol2qm74 398 1 The the DT cord-015021-pol2qm74 398 2 small small JJ cord-015021-pol2qm74 398 3 doses dose NNS cord-015021-pol2qm74 398 4 of of IN cord-015021-pol2qm74 398 5 LPS lp NNS cord-015021-pol2qm74 398 6 stimulate stimulate VBP cord-015021-pol2qm74 398 7 functional functional JJ cord-015021-pol2qm74 398 8 activity activity NN cord-015021-pol2qm74 398 9 of of IN cord-015021-pol2qm74 398 10 macrophages macrophage NNS cord-015021-pol2qm74 398 11 , , , cord-015021-pol2qm74 398 12 the the DT cord-015021-pol2qm74 398 13 large large JJ cord-015021-pol2qm74 398 14 doses dose NNS cord-015021-pol2qm74 398 15 of of IN cord-015021-pol2qm74 398 16 LPS LPS NNP cord-015021-pol2qm74 398 17 -decrease -decrease : cord-015021-pol2qm74 398 18 one one CD cord-015021-pol2qm74 398 19 and and CC cord-015021-pol2qm74 398 20 show show VB cord-015021-pol2qm74 398 21 the the DT cord-015021-pol2qm74 398 22 cytotoxic cytotoxic JJ cord-015021-pol2qm74 398 23 effect effect NN cord-015021-pol2qm74 398 24 . . . cord-015021-pol2qm74 399 1 The the DT cord-015021-pol2qm74 399 2 bioglycans bioglycan NNS cord-015021-pol2qm74 399 3 enhance enhance VBP cord-015021-pol2qm74 399 4 the the DT cord-015021-pol2qm74 399 5 resistance resistance NN cord-015021-pol2qm74 399 6 of of IN cord-015021-pol2qm74 399 7 mice mouse NNS cord-015021-pol2qm74 399 8 to to IN cord-015021-pol2qm74 399 9 the the DT cord-015021-pol2qm74 399 10 lethal lethal JJ cord-015021-pol2qm74 399 11 effect effect NN cord-015021-pol2qm74 399 12 of of IN cord-015021-pol2qm74 399 13 laDS laDS NNP cord-015021-pol2qm74 399 14 and and CC cord-015021-pol2qm74 399 15 provide provide VB cord-015021-pol2qm74 399 16 protection protection NN cord-015021-pol2qm74 399 17 59 59 CD cord-015021-pol2qm74 399 18 - - SYM cord-015021-pol2qm74 399 19 75 75 CD cord-015021-pol2qm74 399 20 % % NN cord-015021-pol2qm74 399 21 of of IN cord-015021-pol2qm74 399 22 mice mouse NNS cord-015021-pol2qm74 399 23 . . . cord-015021-pol2qm74 400 1 One one CD cord-015021-pol2qm74 400 2 opens open VBZ cord-015021-pol2qm74 400 3 possibility possibility NN cord-015021-pol2qm74 400 4 to to IN cord-015021-pol2qm74 400 5 use use NN cord-015021-pol2qm74 400 6 of of IN cord-015021-pol2qm74 400 7 bioglicans bioglican NNS cord-015021-pol2qm74 400 8 for for IN cord-015021-pol2qm74 400 9 reduction reduction NN cord-015021-pol2qm74 400 10 of of IN cord-015021-pol2qm74 400 11 toxinemia toxinemia NN cord-015021-pol2qm74 400 12 in in IN cord-015021-pol2qm74 400 13 generalizated generalizated NNP cord-015021-pol2qm74 400 14 forms form NNS cord-015021-pol2qm74 400 15 of of IN cord-015021-pol2qm74 400 16 pseudotuberculosis pseudotuberculosis NN cord-015021-pol2qm74 400 17 . . . cord-015021-pol2qm74 401 1 Thus thus RB cord-015021-pol2qm74 401 2 , , , cord-015021-pol2qm74 401 3 LPS LPS NNP cord-015021-pol2qm74 401 4 from from IN cord-015021-pol2qm74 401 5 Y.pseudotuberculosis Y.pseudotuberculosis NNP cord-015021-pol2qm74 401 6 is be VBZ cord-015021-pol2qm74 401 7 immunogen immunogen NN cord-015021-pol2qm74 401 8 and and CC cord-015021-pol2qm74 401 9 immunomodulator immunomodulator NNP cord-015021-pol2qm74 401 10 wich wich NNP cord-015021-pol2qm74 401 11 has have VBZ cord-015021-pol2qm74 401 12 influence influence NN cord-015021-pol2qm74 401 13 on on IN cord-015021-pol2qm74 401 14 humoral humoral JJ cord-015021-pol2qm74 401 15 and and CC cord-015021-pol2qm74 401 16 cellular cellular JJ cord-015021-pol2qm74 401 17 factors factor NNS cord-015021-pol2qm74 401 18 of of IN cord-015021-pol2qm74 401 19 immunity immunity NN cord-015021-pol2qm74 401 20 and and CC cord-015021-pol2qm74 401 21 plays play VBZ cord-015021-pol2qm74 401 22 the the DT cord-015021-pol2qm74 401 23 important important JJ cord-015021-pol2qm74 401 24 role role NN cord-015021-pol2qm74 401 25 in in IN cord-015021-pol2qm74 401 26 immunopathogenesis immunopathogenesis NN cord-015021-pol2qm74 401 27 of of IN cord-015021-pol2qm74 401 28 infection infection NN cord-015021-pol2qm74 401 29 . . . cord-015021-pol2qm74 401 30 _SP cord-015021-pol2qm74 402 1 Endotoxaemia Endotoxaemia NNP cord-015021-pol2qm74 402 2 is be VBZ cord-015021-pol2qm74 402 3 implicated implicate VBN cord-015021-pol2qm74 402 4 in in IN cord-015021-pol2qm74 402 5 the the DT cord-015021-pol2qm74 402 6 pathophysiology pathophysiology NN cord-015021-pol2qm74 402 7 of of IN cord-015021-pol2qm74 402 8 obstructive obstructive JJ cord-015021-pol2qm74 402 9 jaundice jaundice NN cord-015021-pol2qm74 402 10 . . . cord-015021-pol2qm74 403 1 The the DT cord-015021-pol2qm74 403 2 Lirnulus Lirnulus NNP cord-015021-pol2qm74 403 3 lysate lysate NN cord-015021-pol2qm74 403 4 ( ( -LRB- cord-015021-pol2qm74 403 5 LAL LAL NNP cord-015021-pol2qm74 403 6 ) ) -RRB- cord-015021-pol2qm74 403 7 assay assay NN cord-015021-pol2qm74 403 8 is be VBZ cord-015021-pol2qm74 403 9 the the DT cord-015021-pol2qm74 403 10 gold gold JJ cord-015021-pol2qm74 403 11 standard standard JJ cord-015021-pol2qm74 403 12 method method NN cord-015021-pol2qm74 403 13 for for IN cord-015021-pol2qm74 403 14 measuring measure VBG cord-015021-pol2qm74 403 15 endotoxin endotoxin NN cord-015021-pol2qm74 403 16 concentrations concentration NNS cord-015021-pol2qm74 403 17 , , , cord-015021-pol2qm74 403 18 but but CC cord-015021-pol2qm74 403 19 inherent inherent JJ cord-015021-pol2qm74 403 20 biochemical biochemical JJ cord-015021-pol2qm74 403 21 and and CC cord-015021-pol2qm74 403 22 technical technical JJ cord-015021-pol2qm74 403 23 problems problem NNS cord-015021-pol2qm74 403 24 limit limit VBP cord-015021-pol2qm74 403 25 the the DT cord-015021-pol2qm74 403 26 usefulness usefulness NN cord-015021-pol2qm74 403 27 of of IN cord-015021-pol2qm74 403 28 this this DT cord-015021-pol2qm74 403 29 assay assay NN cord-015021-pol2qm74 403 30 . . . cord-015021-pol2qm74 404 1 The the DT cord-015021-pol2qm74 404 2 EndoCab EndoCab NNP cord-015021-pol2qm74 404 3 ELISA ELISA NNP cord-015021-pol2qm74 404 4 is be VBZ cord-015021-pol2qm74 404 5 a a DT cord-015021-pol2qm74 404 6 novel novel JJ cord-015021-pol2qm74 404 7 assay assay NN cord-015021-pol2qm74 404 8 which which WDT cord-015021-pol2qm74 404 9 measures measure VBZ cord-015021-pol2qm74 404 10 endogenous endogenous JJ cord-015021-pol2qm74 404 11 antibody antibody NN cord-015021-pol2qm74 404 12 ( ( -LRB- cord-015021-pol2qm74 404 13 IgG IgG NNP cord-015021-pol2qm74 404 14 ) ) -RRB- cord-015021-pol2qm74 404 15 to to IN cord-015021-pol2qm74 404 16 the the DT cord-015021-pol2qm74 404 17 inner inner JJ cord-015021-pol2qm74 404 18 core core NN cord-015021-pol2qm74 404 19 region region NN cord-015021-pol2qm74 404 20 of of IN cord-015021-pol2qm74 404 21 circulating circulate VBG cord-015021-pol2qm74 404 22 endotoxins endotoxin NNS cord-015021-pol2qm74 404 23 ( ( -LRB- cord-015021-pol2qm74 404 24 ACGA ACGA NNP cord-015021-pol2qm74 404 25 ) ) -RRB- cord-015021-pol2qm74 404 26 . . . cord-015021-pol2qm74 405 1 Objectives objective NNS cord-015021-pol2qm74 406 1 We -PRON- PRP cord-015021-pol2qm74 406 2 evaluated evaluate VBD cord-015021-pol2qm74 406 3 the the DT cord-015021-pol2qm74 406 4 significance significance NN cord-015021-pol2qm74 406 5 of of IN cord-015021-pol2qm74 406 6 endotoxaemia endotoxaemia NN cord-015021-pol2qm74 406 7 in in IN cord-015021-pol2qm74 406 8 biliary biliary JJ cord-015021-pol2qm74 406 9 obstruction obstruction NN cord-015021-pol2qm74 406 10 using use VBG cord-015021-pol2qm74 406 11 the the DT cord-015021-pol2qm74 406 12 EndoCab EndoCab NNP cord-015021-pol2qm74 406 13 assay assay NN cord-015021-pol2qm74 406 14 and and CC cord-015021-pol2qm74 406 15 subsequently subsequently RB cord-015021-pol2qm74 406 16 the the DT cord-015021-pol2qm74 406 17 specificity specificity NN cord-015021-pol2qm74 406 18 of of IN cord-015021-pol2qm74 406 19 the the DT cord-015021-pol2qm74 406 20 humoral humoral JJ cord-015021-pol2qm74 406 21 response response NN cord-015021-pol2qm74 406 22 to to TO cord-015021-pol2qm74 406 23 endotoxin endotoxin NN cord-015021-pol2qm74 406 24 compared compare VBN cord-015021-pol2qm74 406 25 with with IN cord-015021-pol2qm74 406 26 an an DT cord-015021-pol2qm74 406 27 exogenous exogenous JJ cord-015021-pol2qm74 406 28 antigenic antigenic JJ cord-015021-pol2qm74 406 29 challenge challenge NN cord-015021-pol2qm74 406 30 [ [ -LRB- cord-015021-pol2qm74 406 31 Tetamls Tetamls NNP cord-015021-pol2qm74 406 32 Toxoid Toxoid NNP cord-015021-pol2qm74 406 33 ( ( -LRB- cord-015021-pol2qm74 406 34 TT TT NNP cord-015021-pol2qm74 406 35 ) ) -RRB- cord-015021-pol2qm74 406 36 ] ] -RRB- cord-015021-pol2qm74 406 37 . . . cord-015021-pol2qm74 407 1 Materials material NNS cord-015021-pol2qm74 407 2 and and CC cord-015021-pol2qm74 407 3 methods method NNS cord-015021-pol2qm74 407 4 In in IN cord-015021-pol2qm74 407 5 Experiment experiment NN cord-015021-pol2qm74 408 1 I -PRON- PRP cord-015021-pol2qm74 408 2 three three CD cord-015021-pol2qm74 408 3 groups group NNS cord-015021-pol2qm74 408 4 of of IN cord-015021-pol2qm74 408 5 male male JJ cord-015021-pol2qm74 408 6 Wistar Wistar NNP cord-015021-pol2qm74 408 7 rats rat NNS cord-015021-pol2qm74 408 8 ( ( -LRB- cord-015021-pol2qm74 408 9 250 250 CD cord-015021-pol2qm74 408 10 - - SYM cord-015021-pol2qm74 408 11 300 300 CD cord-015021-pol2qm74 408 12 g g NN cord-015021-pol2qm74 408 13 ) ) -RRB- cord-015021-pol2qm74 408 14 were be VBD cord-015021-pol2qm74 408 15 studied study VBN cord-015021-pol2qm74 408 16 [ [ -LRB- cord-015021-pol2qm74 408 17 No no DT cord-015021-pol2qm74 408 18 operation operation NN cord-015021-pol2qm74 408 19 ( ( -LRB- cord-015021-pol2qm74 408 20 n=39 n=39 NNP cord-015021-pol2qm74 408 21 ) ) -RRB- cord-015021-pol2qm74 408 22 , , , cord-015021-pol2qm74 408 23 Sham Sham NNP cord-015021-pol2qm74 408 24 operation operation NN cord-015021-pol2qm74 408 25 ( ( -LRB- cord-015021-pol2qm74 408 26 n=40 n=40 NNP cord-015021-pol2qm74 408 27 ) ) -RRB- cord-015021-pol2qm74 408 28 , , , cord-015021-pol2qm74 408 29 and and CC cord-015021-pol2qm74 408 30 Bile bile NN cord-015021-pol2qm74 408 31 Duct duct NN cord-015021-pol2qm74 408 32 Ligation ligation NN cord-015021-pol2qm74 408 33 for for IN cord-015021-pol2qm74 408 34 21 21 CD cord-015021-pol2qm74 408 35 days day NNS cord-015021-pol2qm74 408 36 ( ( -LRB- cord-015021-pol2qm74 408 37 BDL)(n=50 BDL)(n=50 NNP cord-015021-pol2qm74 408 38 ) ) -RRB- cord-015021-pol2qm74 408 39 ] ] -RRB- cord-015021-pol2qm74 408 40 . . . cord-015021-pol2qm74 409 1 Plasma plasma NN cord-015021-pol2qm74 409 2 was be VBD cord-015021-pol2qm74 409 3 collected collect VBN cord-015021-pol2qm74 409 4 and and CC cord-015021-pol2qm74 409 5 assayed assay VBN cord-015021-pol2qm74 409 6 for for IN cord-015021-pol2qm74 409 7 Bilirubin bilirubin NN cord-015021-pol2qm74 409 8 , , , cord-015021-pol2qm74 409 9 Endntoxin(LAL Endntoxin(LAL NNP cord-015021-pol2qm74 409 10 ) ) -RRB- cord-015021-pol2qm74 409 11 and and CC cord-015021-pol2qm74 409 12 ACGA(EndoCab ACGA(EndoCab NNP cord-015021-pol2qm74 409 13 ) ) -RRB- cord-015021-pol2qm74 409 14 . . . cord-015021-pol2qm74 410 1 In in IN cord-015021-pol2qm74 410 2 Experiment Experiment NNP cord-015021-pol2qm74 410 3 II II NNP cord-015021-pol2qm74 410 4 30 30 CD cord-015021-pol2qm74 410 5 rats rat NNS cord-015021-pol2qm74 410 6 were be VBD cord-015021-pol2qm74 410 7 actively actively RB cord-015021-pol2qm74 410 8 immunised immunise VBN cord-015021-pol2qm74 410 9 with with IN cord-015021-pol2qm74 410 10 Tetanus Tetanus NNP cord-015021-pol2qm74 410 11 Toxoid Toxoid NNP cord-015021-pol2qm74 410 12 ( ( -LRB- cord-015021-pol2qm74 410 13 ' ' '' cord-015021-pol2qm74 410 14 IT it NN cord-015021-pol2qm74 410 15 ) ) -RRB- cord-015021-pol2qm74 410 16 and and CC cord-015021-pol2qm74 410 17 then then RB cord-015021-pol2qm74 410 18 randomised randomise VBD cord-015021-pol2qm74 410 19 to to TO cord-015021-pol2qm74 410 20 have have VB cord-015021-pol2qm74 410 21 No no DT cord-015021-pol2qm74 410 22 op(n=8 op(n=8 NN cord-015021-pol2qm74 410 23 ) ) -RRB- cord-015021-pol2qm74 410 24 , , , cord-015021-pol2qm74 410 25 Sham Sham NNP cord-015021-pol2qm74 410 26 op(n=8 op(n=8 NNP cord-015021-pol2qm74 410 27 ) ) -RRB- cord-015021-pol2qm74 410 28 or or CC cord-015021-pol2qm74 410 29 BDL(n bdl(n NN cord-015021-pol2qm74 410 30 = = SYM cord-015021-pol2qm74 410 31 I4 I4 NNP cord-015021-pol2qm74 410 32 ) ) -RRB- cord-015021-pol2qm74 410 33 . . . cord-015021-pol2qm74 411 1 Blood blood NN cord-015021-pol2qm74 411 2 was be VBD cord-015021-pol2qm74 411 3 taken take VBN cord-015021-pol2qm74 411 4 at at IN cord-015021-pol2qm74 411 5 this this DT cord-015021-pol2qm74 411 6 time time NN cord-015021-pol2qm74 411 7 ( ( -LRB- cord-015021-pol2qm74 411 8 To to IN cord-015021-pol2qm74 411 9 ) ) -RRB- cord-015021-pol2qm74 411 10 and and CC cord-015021-pol2qm74 411 11 21 21 CD cord-015021-pol2qm74 411 12 days day NNS cord-015021-pol2qm74 411 13 later(T20 later(t20 WDT cord-015021-pol2qm74 411 14 at at IN cord-015021-pol2qm74 411 15 sacrifice sacrifice NN cord-015021-pol2qm74 411 16 for for IN cord-015021-pol2qm74 411 17 ACGA ACGA NNP cord-015021-pol2qm74 411 18 concentrationslEndoCab concentrationslEndoCab NNP cord-015021-pol2qm74 411 19 ] ] -RRB- cord-015021-pol2qm74 411 20 and and CC cord-015021-pol2qm74 411 21 IgG IgG NNP cord-015021-pol2qm74 411 22 Produced produce VBD cord-015021-pol2qm74 411 23 to to IN cord-015021-pol2qm74 411 24 TT(TTab TT(TTab NNP cord-015021-pol2qm74 411 25 ) ) -RRB- cord-015021-pol2qm74 412 1 [ [ -LRB- cord-015021-pol2qm74 412 2 ELISA ELISA NNP cord-015021-pol2qm74 412 3 ] ] -RRB- cord-015021-pol2qm74 412 4 . . . cord-015021-pol2qm74 413 1 Antibody antibody NN cord-015021-pol2qm74 413 2 concentrations concentration NNS cord-015021-pol2qm74 413 3 are be VBP cord-015021-pol2qm74 413 4 expressed express VBN cord-015021-pol2qm74 413 5 as as IN cord-015021-pol2qm74 413 6 % % NN cord-015021-pol2qm74 413 7 increase increase NN cord-015021-pol2qm74 413 8 from from IN cord-015021-pol2qm74 413 9 control control NN cord-015021-pol2qm74 413 10 values value NNS cord-015021-pol2qm74 413 11 . . . cord-015021-pol2qm74 414 1 Results result NNS cord-015021-pol2qm74 414 2 In in IN cord-015021-pol2qm74 414 3 BDL BDL NNP cord-015021-pol2qm74 414 4 rats rat NNS cord-015021-pol2qm74 415 1 , , , cord-015021-pol2qm74 415 2 ACGA ACGA NNP cord-015021-pol2qm74 415 3 concentrations concentration NNS cord-015021-pol2qm74 415 4 were be VBD cord-015021-pol2qm74 415 5 significantly significantly RB cord-015021-pol2qm74 415 6 increased increase VBN cord-015021-pol2qm74 415 7 compared compare VBN cord-015021-pol2qm74 415 8 with with IN cord-015021-pol2qm74 415 9 controlslP<0.001 controlslP<0.001 NNP cord-015021-pol2qm74 415 10 , , , cord-015021-pol2qm74 415 11 Mann Mann NNP cord-015021-pol2qm74 415 12 - - HYPH cord-015021-pol2qm74 415 13 Whitney Whitney NNP cord-015021-pol2qm74 415 14 ] ] -RRB- cord-015021-pol2qm74 415 15 . . . cord-015021-pol2qm74 416 1 Endotoxin endotoxin NN cord-015021-pol2qm74 416 2 concentrations concentration NNS cord-015021-pol2qm74 416 3 were be VBD cord-015021-pol2qm74 416 4 sporadically sporadically RB cord-015021-pol2qm74 416 5 elevated elevate VBN cord-015021-pol2qm74 416 6 in in IN cord-015021-pol2qm74 416 7 the the DT cord-015021-pol2qm74 416 8 jaundiced jaundiced JJ cord-015021-pol2qm74 416 9 rats rat NNS cord-015021-pol2qm74 416 10 but but CC cord-015021-pol2qm74 416 11 the the DT cord-015021-pol2qm74 416 12 rise rise NN cord-015021-pol2qm74 416 13 was be VBD cord-015021-pol2qm74 416 14 not not RB cord-015021-pol2qm74 416 15 significant significant JJ cord-015021-pol2qm74 416 16 . . . cord-015021-pol2qm74 417 1 In in IN cord-015021-pol2qm74 417 2 Experiment experiment NN cord-015021-pol2qm74 417 3 [ [ -LRB- cord-015021-pol2qm74 417 4 I -PRON- PRP cord-015021-pol2qm74 417 5 there there EX cord-015021-pol2qm74 417 6 was be VBD cord-015021-pol2qm74 417 7 no no DT cord-015021-pol2qm74 417 8 difference difference NN cord-015021-pol2qm74 417 9 between between IN cord-015021-pol2qm74 417 10 the the DT cord-015021-pol2qm74 417 11 ACGA ACGA NNP cord-015021-pol2qm74 417 12 or or CC cord-015021-pol2qm74 417 13 TTab TTab NNP cord-015021-pol2qm74 417 14 concentrations concentration NNS cord-015021-pol2qm74 417 15 in in IN cord-015021-pol2qm74 417 16 the the DT cord-015021-pol2qm74 417 17 fllree fllree NNP cord-015021-pol2qm74 417 18 groups group NNS cord-015021-pol2qm74 417 19 at at IN cord-015021-pol2qm74 417 20 To To NNP cord-015021-pol2qm74 417 21 , , , cord-015021-pol2qm74 417 22 BDL BDL NNP cord-015021-pol2qm74 417 23 rats rat NNS cord-015021-pol2qm74 417 24 had have VBD cord-015021-pol2qm74 417 25 a a DT cord-015021-pol2qm74 417 26 significant significant JJ cord-015021-pol2qm74 417 27 rise rise NN cord-015021-pol2qm74 417 28 in in IN cord-015021-pol2qm74 417 29 ACGA ACGA NNP cord-015021-pol2qm74 417 30 concentrations concentration NNS cord-015021-pol2qm74 417 31 by by IN cord-015021-pol2qm74 417 32 T21 T21 NNP cord-015021-pol2qm74 417 33 [ [ -LRB- cord-015021-pol2qm74 417 34 P<0,001,paired p<0,001,paired JJ cord-015021-pol2qm74 417 35 t t NN cord-015021-pol2qm74 417 36 - - HYPH cord-015021-pol2qm74 417 37 test test NN cord-015021-pol2qm74 417 38 ] ] -RRB- cord-015021-pol2qm74 417 39 and and CC cord-015021-pol2qm74 417 40 humoral humoral JJ cord-015021-pol2qm74 417 41 response response NN cord-015021-pol2qm74 417 42 to to IN cord-015021-pol2qm74 417 43 TT TT NNP cord-015021-pol2qm74 417 44 was be VBD cord-015021-pol2qm74 417 45 significantly significantly RB cord-015021-pol2qm74 417 46 impaired impair VBN cord-015021-pol2qm74 417 47 in in IN cord-015021-pol2qm74 417 48 BDL BDL NNP cord-015021-pol2qm74 417 49 rats rat NNS cord-015021-pol2qm74 417 50 compared compare VBN cord-015021-pol2qm74 417 51 with with IN cord-015021-pol2qm74 417 52 control control NN cord-015021-pol2qm74 417 53 groupslP<0.05 groupslP<0.05 NNP cord-015021-pol2qm74 417 54 , , , cord-015021-pol2qm74 417 55 paired pair VBN cord-015021-pol2qm74 417 56 ttest ttest NNP cord-015021-pol2qm74 418 1 Data Data NNP cord-015021-pol2qm74 418 2 Plasma Plasma NNP cord-015021-pol2qm74 418 3 endotoxin endotoxin NN cord-015021-pol2qm74 418 4 was be VBD cord-015021-pol2qm74 418 5 measured measure VBN cord-015021-pol2qm74 418 6 by by IN cord-015021-pol2qm74 418 7 means mean NNS cord-015021-pol2qm74 418 8 of of IN cord-015021-pol2qm74 418 9 an an DT cord-015021-pol2qm74 418 10 endotoxinspecific endotoxinspecific JJ cord-015021-pol2qm74 418 11 Endospecy Endospecy NNP cord-015021-pol2qm74 418 12 test test NN cord-015021-pol2qm74 418 13 after after IN cord-015021-pol2qm74 418 14 pretreatment pretreatment NN cord-015021-pol2qm74 418 15 of of IN cord-015021-pol2qm74 418 16 the the DT cord-015021-pol2qm74 418 17 plasma plasma NN cord-015021-pol2qm74 418 18 with with IN cord-015021-pol2qm74 418 19 a a DT cord-015021-pol2qm74 418 20 new new JJ cord-015021-pol2qm74 418 21 perchloric perchloric JJ cord-015021-pol2qm74 418 22 acid acid NN cord-015021-pol2qm74 418 23 method method NN cord-015021-pol2qm74 418 24 that that WDT cord-015021-pol2qm74 418 25 we -PRON- PRP cord-015021-pol2qm74 418 26 developed develop VBD cord-015021-pol2qm74 418 27 . . . cord-015021-pol2qm74 419 1 The the DT cord-015021-pol2qm74 419 2 normal normal JJ cord-015021-pol2qm74 419 3 value value NN cord-015021-pol2qm74 419 4 of of IN cord-015021-pol2qm74 419 5 plasma plasma NN cord-015021-pol2qm74 419 6 endotoxin endotoxin NN cord-015021-pol2qm74 419 7 is be VBZ cord-015021-pol2qm74 419 8 less less JJR cord-015021-pol2qm74 419 9 than than IN cord-015021-pol2qm74 419 10 9.8 9.8 CD cord-015021-pol2qm74 419 11 pglml pglml NNS cord-015021-pol2qm74 419 12 . . . cord-015021-pol2qm74 420 1 Polymyxin Polymyxin NNP cord-015021-pol2qm74 420 2 B B NNP cord-015021-pol2qm74 420 3 was be VBD cord-015021-pol2qm74 420 4 administered administer VBN cord-015021-pol2qm74 420 5 at at IN cord-015021-pol2qm74 420 6 a a DT cord-015021-pol2qm74 420 7 dose dose NN cord-015021-pol2qm74 420 8 of of IN cord-015021-pol2qm74 420 9 12,500 12,500 CD cord-015021-pol2qm74 420 10 U u NN cord-015021-pol2qm74 420 11 every every DT cord-015021-pol2qm74 420 12 6 6 CD cord-015021-pol2qm74 420 13 hours hour NNS cord-015021-pol2qm74 420 14 . . . cord-015021-pol2qm74 421 1 Plasma plasma NN cord-015021-pol2qm74 421 2 endotoxin endotoxin NN cord-015021-pol2qm74 421 3 rapidly rapidly RB cord-015021-pol2qm74 421 4 decreased decrease VBD cord-015021-pol2qm74 421 5 to to IN cord-015021-pol2qm74 421 6 the the DT cord-015021-pol2qm74 421 7 normal normal JJ cord-015021-pol2qm74 421 8 range range NN cord-015021-pol2qm74 421 9 in in IN cord-015021-pol2qm74 421 10 40 40 CD cord-015021-pol2qm74 421 11 of of IN cord-015021-pol2qm74 421 12 the the DT cord-015021-pol2qm74 421 13 42 42 CD cord-015021-pol2qm74 421 14 patients patient NNS cord-015021-pol2qm74 421 15 . . . cord-015021-pol2qm74 422 1 Body body NN cord-015021-pol2qm74 422 2 temperature temperature NN cord-015021-pol2qm74 422 3 fall fall VBP cord-015021-pol2qm74 422 4 significantly significantly RB cord-015021-pol2qm74 422 5 . . . cord-015021-pol2qm74 423 1 APACHE APACHE NNP cord-015021-pol2qm74 423 2 II II NNP cord-015021-pol2qm74 423 3 scores score NNS cord-015021-pol2qm74 423 4 were be VBD cord-015021-pol2qm74 423 5 also also RB cord-015021-pol2qm74 423 6 significantly significantly RB cord-015021-pol2qm74 423 7 improved improve VBN cord-015021-pol2qm74 423 8 . . . cord-015021-pol2qm74 424 1 Tumor tumor NN cord-015021-pol2qm74 424 2 necrosis necrosis NN cord-015021-pol2qm74 424 3 factor factor NN cord-015021-pol2qm74 424 4 - - HYPH cord-015021-pol2qm74 424 5 o~ o~ XX cord-015021-pol2qm74 424 6 and and CC cord-015021-pol2qm74 424 7 interleukin interleukin NN cord-015021-pol2qm74 424 8 6 6 CD cord-015021-pol2qm74 424 9 decreased decrease VBD cord-015021-pol2qm74 424 10 in in IN cord-015021-pol2qm74 424 11 survivors survivor NNS cord-015021-pol2qm74 424 12 , , , cord-015021-pol2qm74 424 13 while while IN cord-015021-pol2qm74 424 14 in in IN cord-015021-pol2qm74 424 15 high high JJ cord-015021-pol2qm74 424 16 values value NNS cord-015021-pol2qm74 424 17 tended tend VBD cord-015021-pol2qm74 424 18 to to TO cord-015021-pol2qm74 424 19 persist persist VB cord-015021-pol2qm74 424 20 in in IN cord-015021-pol2qm74 424 21 patients patient NNS cord-015021-pol2qm74 424 22 died die VBD cord-015021-pol2qm74 424 23 . . . cord-015021-pol2qm74 425 1 No no DT cord-015021-pol2qm74 425 2 side side NN cord-015021-pol2qm74 425 3 effects effect NNS cord-015021-pol2qm74 425 4 were be VBD cord-015021-pol2qm74 425 5 observed observe VBN cord-015021-pol2qm74 425 6 in in IN cord-015021-pol2qm74 425 7 any any DT cord-015021-pol2qm74 425 8 of of IN cord-015021-pol2qm74 425 9 the the DT cord-015021-pol2qm74 425 10 patients patient NNS cord-015021-pol2qm74 425 11 . . . cord-015021-pol2qm74 426 1 In in IN cord-015021-pol2qm74 426 2 conclusion conclusion NN cord-015021-pol2qm74 426 3 , , , cord-015021-pol2qm74 426 4 intramuscular intramuscular JJ cord-015021-pol2qm74 426 5 injection injection NN cord-015021-pol2qm74 426 6 of of IN cord-015021-pol2qm74 426 7 minute minute NN cord-015021-pol2qm74 426 8 of of IN cord-015021-pol2qm74 426 9 Polymyxin Polymyxin NNP cord-015021-pol2qm74 426 10 B B NNP cord-015021-pol2qm74 426 11 was be VBD cord-015021-pol2qm74 426 12 useful useful JJ cord-015021-pol2qm74 426 13 in in IN cord-015021-pol2qm74 426 14 the the DT cord-015021-pol2qm74 426 15 treatment treatment NN cord-015021-pol2qm74 426 16 of of IN cord-015021-pol2qm74 426 17 endotoxemia endotoxemia NN cord-015021-pol2qm74 426 18 . . . cord-015021-pol2qm74 427 1 19 19 CD cord-015021-pol2qm74 427 2 - - SYM cord-015021-pol2qm74 427 3 1 1 CD cord-015021-pol2qm74 427 4 Uchimaru Uchimaru NNP cord-015021-pol2qm74 427 5 , , , cord-015021-pol2qm74 427 6 Morioka Morioka NNP cord-015021-pol2qm74 427 7 020 020 CD cord-015021-pol2qm74 427 8 , , , cord-015021-pol2qm74 427 9 Japan Japan NNP cord-015021-pol2qm74 427 10 . . . cord-015021-pol2qm74 428 1 l l NN cord-015021-pol2qm74 428 2 e e NN cord-015021-pol2qm74 428 3 v v NN cord-015021-pol2qm74 428 4 a a NN cord-015021-pol2qm74 428 5 n n NN cord-015021-pol2qm74 428 6 t t NN cord-015021-pol2qm74 428 7 G g NN cord-015021-pol2qm74 428 8 r r NN cord-015021-pol2qm74 428 9 a a DT cord-015021-pol2qm74 428 10 m m NN cord-015021-pol2qm74 428 11 n n NN cord-015021-pol2qm74 428 12 e e NN cord-015021-pol2qm74 428 13 g g NN cord-015021-pol2qm74 428 14 a a DT cord-015021-pol2qm74 428 15 t t NN cord-015021-pol2qm74 429 1 i i PRP cord-015021-pol2qm74 429 2 v v IN cord-015021-pol2qm74 429 3 organisms organism NNS cord-015021-pol2qm74 429 4 . . . cord-015021-pol2qm74 430 1 M m NN cord-015021-pol2qm74 430 2 e e NN cord-015021-pol2qm74 430 3 t t NN cord-015021-pol2qm74 430 4 h h NN cord-015021-pol2qm74 430 5 o o NN cord-015021-pol2qm74 430 6 d d NN cord-015021-pol2qm74 430 7 s s NN cord-015021-pol2qm74 430 8 : : : cord-015021-pol2qm74 430 9 U U NNP cord-015021-pol2qm74 430 10 n n NN cord-015021-pol2qm74 430 11 d d NN cord-015021-pol2qm74 430 12 e e NNP cord-015021-pol2qm74 430 13 r r NNP cord-015021-pol2qm74 430 14 general general NNP cord-015021-pol2qm74 430 15 anesthesia anesthesia NNP cord-015021-pol2qm74 430 16 , , , cord-015021-pol2qm74 431 1 12 12 CD cord-015021-pol2qm74 431 2 N n NN cord-015021-pol2qm74 431 3 o o NN cord-015021-pol2qm74 431 4 r r NN cord-015021-pol2qm74 431 5 w w NN cord-015021-pol2qm74 431 6 e e NN cord-015021-pol2qm74 431 7 g g NN cord-015021-pol2qm74 432 1 i i PRP cord-015021-pol2qm74 433 1 a a DT cord-015021-pol2qm74 433 2 n n NN cord-015021-pol2qm74 433 3 b b NN cord-015021-pol2qm74 433 4 r r NN cord-015021-pol2qm74 433 5 e e NN cord-015021-pol2qm74 433 6 d d NN cord-015021-pol2qm74 433 7 landrace landrace NN cord-015021-pol2qm74 433 8 pigs pig NNS cord-015021-pol2qm74 433 9 ( ( -LRB- cord-015021-pol2qm74 433 10 17 17 CD cord-015021-pol2qm74 433 11 - - SYM cord-015021-pol2qm74 433 12 30 30 CD cord-015021-pol2qm74 433 13 kg kg NNP cord-015021-pol2qm74 433 14 ) ) -RRB- cord-015021-pol2qm74 433 15 of of IN cord-015021-pol2qm74 433 16 either either DT cord-015021-pol2qm74 433 17 sex sex NN cord-015021-pol2qm74 433 18 , , , cord-015021-pol2qm74 433 19 6 6 CD cord-015021-pol2qm74 433 20 pr pr NN cord-015021-pol2qm74 433 21 group group NN cord-015021-pol2qm74 433 22 , , , cord-015021-pol2qm74 434 1 u u NNP cord-015021-pol2qm74 434 2 n n NNP cord-015021-pol2qm74 434 3 d d NNP cord-015021-pol2qm74 434 4 e e NN cord-015021-pol2qm74 435 1 r r LS cord-015021-pol2qm74 436 1 w w NNP cord-015021-pol2qm74 436 2 e e NN cord-015021-pol2qm74 436 3 n n NN cord-015021-pol2qm74 436 4 t t NNP cord-015021-pol2qm74 436 5 t t NN cord-015021-pol2qm74 437 1 r r LS cord-015021-pol2qm74 437 2 a a DT cord-015021-pol2qm74 437 3 c c NN cord-015021-pol2qm74 437 4 h h NN cord-015021-pol2qm74 438 1 e e LS cord-015021-pol2qm74 438 2 o o NN cord-015021-pol2qm74 439 1 s s NNP cord-015021-pol2qm74 440 1 t t NNP cord-015021-pol2qm74 440 2 o o NNP cord-015021-pol2qm74 441 1 m m NNP cord-015021-pol2qm74 441 2 y y NNP cord-015021-pol2qm74 442 1 a a DT cord-015021-pol2qm74 442 2 n n NNP cord-015021-pol2qm74 442 3 d d NNP cord-015021-pol2qm74 442 4 w w NN cord-015021-pol2qm74 442 5 e e NN cord-015021-pol2qm74 442 6 r r NN cord-015021-pol2qm74 442 7 e e NN cord-015021-pol2qm74 442 8 v v NN cord-015021-pol2qm74 443 1 e e LS cord-015021-pol2qm74 443 2 n n NN cord-015021-pol2qm74 443 3 t t NN cord-015021-pol2qm74 444 1 i i PRP cord-015021-pol2qm74 444 2 l l NNP cord-015021-pol2qm74 444 3 a a DT cord-015021-pol2qm74 444 4 t t NN cord-015021-pol2qm74 444 5 e e NN cord-015021-pol2qm74 444 6 d d NN cord-015021-pol2qm74 444 7 on on IN cord-015021-pol2qm74 444 8 a a DT cord-015021-pol2qm74 444 9 50/50 50/50 CD cord-015021-pol2qm74 444 10 air air NN cord-015021-pol2qm74 445 1 a a LS cord-015021-pol2qm74 446 1 n n NNP cord-015021-pol2qm74 446 2 d d NNP cord-015021-pol2qm74 447 1 o o UH cord-015021-pol2qm74 448 1 x x SYM cord-015021-pol2qm74 448 2 y y NNP cord-015021-pol2qm74 448 3 g g NN cord-015021-pol2qm74 449 1 e e NN cord-015021-pol2qm74 449 2 n n NN cord-015021-pol2qm74 449 3 m m NNP cord-015021-pol2qm74 450 1 i i PRP cord-015021-pol2qm74 451 1 x x LS cord-015021-pol2qm74 452 1 t t NNP cord-015021-pol2qm74 452 2 u u NNP cord-015021-pol2qm74 452 3 r r NN cord-015021-pol2qm74 452 4 e e NN cord-015021-pol2qm74 453 1 a a DT cord-015021-pol2qm74 453 2 i i NN cord-015021-pol2qm74 453 3 m m NN cord-015021-pol2qm74 453 4 e e NN cord-015021-pol2qm74 453 5 d d NN cord-015021-pol2qm74 453 6 at at IN cord-015021-pol2qm74 453 7 m m NNP cord-015021-pol2qm74 454 1 a a DT cord-015021-pol2qm74 454 2 i i NN cord-015021-pol2qm74 454 3 n n NN cord-015021-pol2qm74 454 4 t t NN cord-015021-pol2qm74 455 1 a a LS cord-015021-pol2qm74 456 1 i i PRP cord-015021-pol2qm74 456 2 n n CC cord-015021-pol2qm74 456 3 i i NNP cord-015021-pol2qm74 456 4 n n CC cord-015021-pol2qm74 456 5 g g NNP cord-015021-pol2qm74 456 6 a a NNP cord-015021-pol2qm74 456 7 n n NN cord-015021-pol2qm74 456 8 o o NN cord-015021-pol2qm74 456 9 r r NN cord-015021-pol2qm74 456 10 m m NN cord-015021-pol2qm74 456 11 a a NN cord-015021-pol2qm74 456 12 l l NN cord-015021-pol2qm74 456 13 p p NN cord-015021-pol2qm74 456 14 H h NN cord-015021-pol2qm74 456 15 a a NN cord-015021-pol2qm74 456 16 n n NN cord-015021-pol2qm74 456 17 d d NN cord-015021-pol2qm74 456 18 a a DT cord-015021-pol2qm74 456 19 isocapnic isocapnic JJ cord-015021-pol2qm74 456 20 level level NN cord-015021-pol2qm74 456 21 . . . cord-015021-pol2qm74 457 1 Ventilation ventilation NN cord-015021-pol2qm74 457 2 w w NN cord-015021-pol2qm74 458 1 a a DT cord-015021-pol2qm74 458 2 s s NN cord-015021-pol2qm74 458 3 not not RB cord-015021-pol2qm74 458 4 readjusted readjust VBN cord-015021-pol2qm74 459 1 d d NNP cord-015021-pol2qm74 460 1 u u NNP cord-015021-pol2qm74 460 2 r r NNP cord-015021-pol2qm74 460 3 i i NN cord-015021-pol2qm74 460 4 n n CC cord-015021-pol2qm74 460 5 g g NNP cord-015021-pol2qm74 460 6 the the DT cord-015021-pol2qm74 460 7 observation observation NN cord-015021-pol2qm74 460 8 period period NN cord-015021-pol2qm74 460 9 . . . cord-015021-pol2qm74 461 1 The the DT cord-015021-pol2qm74 461 2 anesthesia anesthesia NN cord-015021-pol2qm74 461 3 w w NNP cord-015021-pol2qm74 461 4 a a DT cord-015021-pol2qm74 461 5 s s NN cord-015021-pol2qm74 462 1 K K NNP cord-015021-pol2qm74 462 2 e e NN cord-015021-pol2qm74 462 3 t t NN cord-015021-pol2qm74 462 4 a a DT cord-015021-pol2qm74 462 5 m m NNP cord-015021-pol2qm74 462 6 i i NN cord-015021-pol2qm74 462 7 n n NN cord-015021-pol2qm74 462 8 e e NN cord-015021-pol2qm74 462 9 0.6 0.6 CD cord-015021-pol2qm74 462 10 m m NN cord-015021-pol2qm74 462 11 g g NN cord-015021-pol2qm74 462 12 / / , cord-015021-pol2qm74 463 1 k k NNP cord-015021-pol2qm74 464 1 g g NNP cord-015021-pol2qm74 464 2 h h NNP cord-015021-pol2qm74 465 1 a a DT cord-015021-pol2qm74 465 2 n n NN cord-015021-pol2qm74 465 3 d d NN cord-015021-pol2qm74 465 4 D d NN cord-015021-pol2qm74 465 5 i i NN cord-015021-pol2qm74 465 6 a a DT cord-015021-pol2qm74 465 7 z z NN cord-015021-pol2qm74 465 8 e e NN cord-015021-pol2qm74 465 9 p p NN cord-015021-pol2qm74 465 10 a a DT cord-015021-pol2qm74 465 11 m m NNP cord-015021-pol2qm74 465 12 2.4 2.4 CD cord-015021-pol2qm74 465 13 m m NN cord-015021-pol2qm74 465 14 g g NN cord-015021-pol2qm74 465 15 / / , cord-015021-pol2qm74 466 1 k k NNP cord-015021-pol2qm74 467 1 g g NNP cord-015021-pol2qm74 467 2 h h NNP cord-015021-pol2qm74 468 1 i i PRP cord-015021-pol2qm74 468 2 n n CC cord-015021-pol2qm74 468 3 t t NNP cord-015021-pol2qm74 468 4 r r NNP cord-015021-pol2qm74 468 5 a a NN cord-015021-pol2qm74 468 6 v v NN cord-015021-pol2qm74 468 7 e e NN cord-015021-pol2qm74 468 8 n n NN cord-015021-pol2qm74 468 9 o o NN cord-015021-pol2qm74 468 10 u u NN cord-015021-pol2qm74 468 11 s s NNP cord-015021-pol2qm74 468 12 l l NNP cord-015021-pol2qm74 468 13 y y NNP cord-015021-pol2qm74 468 14 . . . cord-015021-pol2qm74 469 1 H h NN cord-015021-pol2qm74 469 2 e e NN cord-015021-pol2qm74 469 3 m m NN cord-015021-pol2qm74 469 4 o o NN cord-015021-pol2qm74 469 5 d d NN cord-015021-pol2qm74 470 1 y y NNP cord-015021-pol2qm74 470 2 n n NNP cord-015021-pol2qm74 471 1 a a DT cord-015021-pol2qm74 471 2 m m NN cord-015021-pol2qm74 471 3 i i NN cord-015021-pol2qm74 472 1 c c NNP cord-015021-pol2qm74 473 1 m m LS cord-015021-pol2qm74 473 2 o o NN cord-015021-pol2qm74 474 1 n n NNP cord-015021-pol2qm74 475 1 i i PRP cord-015021-pol2qm74 476 1 t t NNP cord-015021-pol2qm74 477 1 o o UH cord-015021-pol2qm74 477 2 r r NN cord-015021-pol2qm74 477 3 i i NN cord-015021-pol2qm74 477 4 n n NN cord-015021-pol2qm74 477 5 g g NNP cord-015021-pol2qm74 477 6 of of IN cord-015021-pol2qm74 477 7 m m NNP cord-015021-pol2qm74 477 8 e e NNP cord-015021-pol2qm74 477 9 a a NNP cord-015021-pol2qm74 477 10 n n NN cord-015021-pol2qm74 477 11 aorta aorta NN cord-015021-pol2qm74 477 12 , , . cord-015021-pol2qm74 478 1 p p NN cord-015021-pol2qm74 478 2 u u NN cord-015021-pol2qm74 478 3 l l NN cord-015021-pol2qm74 478 4 m m NN cord-015021-pol2qm74 478 5 o o NN cord-015021-pol2qm74 478 6 n n NN cord-015021-pol2qm74 478 7 a a DT cord-015021-pol2qm74 478 8 r r NN cord-015021-pol2qm74 478 9 y y NNP cord-015021-pol2qm74 478 10 artery artery NN cord-015021-pol2qm74 478 11 , , , cord-015021-pol2qm74 478 12 central central NNP cord-015021-pol2qm74 478 13 v v NN cord-015021-pol2qm74 478 14 e e NN cord-015021-pol2qm74 478 15 n n NN cord-015021-pol2qm74 478 16 o o NN cord-015021-pol2qm74 478 17 u u NNP cord-015021-pol2qm74 478 18 s s NNP cord-015021-pol2qm74 478 19 a a NNP cord-015021-pol2qm74 478 20 n n NN cord-015021-pol2qm74 478 21 d d NN cord-015021-pol2qm74 478 22 p p NN cord-015021-pol2qm74 479 1 u u NNP cord-015021-pol2qm74 479 2 l l NNP cord-015021-pol2qm74 479 3 m m NN cord-015021-pol2qm74 480 1 o o UH cord-015021-pol2qm74 480 2 n n NN cord-015021-pol2qm74 481 1 a a DT cord-015021-pol2qm74 481 2 r r NNP cord-015021-pol2qm74 481 3 y y NN cord-015021-pol2qm74 481 4 capillary capillary NN cord-015021-pol2qm74 482 1 w w NNP cord-015021-pol2qm74 482 2 e e NN cord-015021-pol2qm74 482 3 d d NN cord-015021-pol2qm74 482 4 g g NN cord-015021-pol2qm74 482 5 e e NN cord-015021-pol2qm74 482 6 pressures pressure NNS cord-015021-pol2qm74 482 7 w w NNP cord-015021-pol2qm74 482 8 a a DT cord-015021-pol2qm74 482 9 s s NN cord-015021-pol2qm74 482 10 p p NN cord-015021-pol2qm74 482 11 e e NN cord-015021-pol2qm74 482 12 r r NN cord-015021-pol2qm74 482 13 f f NN cord-015021-pol2qm74 483 1 o o UH cord-015021-pol2qm74 483 2 r r NN cord-015021-pol2qm74 483 3 m m NN cord-015021-pol2qm74 483 4 e e NN cord-015021-pol2qm74 483 5 d d NN cord-015021-pol2qm74 484 1 w w NNP cord-015021-pol2qm74 484 2 i i PRP cord-015021-pol2qm74 484 3 t t NN cord-015021-pol2qm74 484 4 h h NN cord-015021-pol2qm74 485 1 a a DT cord-015021-pol2qm74 485 2 5F 5F NNP cord-015021-pol2qm74 485 3 S S NNP cord-015021-pol2qm74 485 4 w w NNP cord-015021-pol2qm74 485 5 a a DT cord-015021-pol2qm74 485 6 n n XX cord-015021-pol2qm74 485 7 -G -G : cord-015021-pol2qm74 485 8 a a NN cord-015021-pol2qm74 485 9 n n NN cord-015021-pol2qm74 485 10 z z NNP cord-015021-pol2qm74 485 11 catheter catheter NN cord-015021-pol2qm74 485 12 a a DT cord-015021-pol2qm74 485 13 n n NN cord-015021-pol2qm74 485 14 d d NN cord-015021-pol2qm74 485 15 an an DT cord-015021-pol2qm74 485 16 aorta aorta JJ cord-015021-pol2qm74 485 17 catheter catheter NN cord-015021-pol2qm74 485 18 . . . cord-015021-pol2qm74 486 1 A a DT cord-015021-pol2qm74 486 2 continous continous JJ cord-015021-pol2qm74 486 3 infusion infusion NN cord-015021-pol2qm74 486 4 of of IN cord-015021-pol2qm74 486 5 R r NN cord-015021-pol2qm74 486 6 i i NN cord-015021-pol2qm74 486 7 n n NN cord-015021-pol2qm74 486 8 g g NN cord-015021-pol2qm74 486 9 e e NN cord-015021-pol2qm74 486 10 r r NN cord-015021-pol2qm74 486 11 ' ' '' cord-015021-pol2qm74 486 12 s s NN cord-015021-pol2qm74 486 13 acetate acetate NN cord-015021-pol2qm74 486 14 ( ( -LRB- cord-015021-pol2qm74 486 15 1 1 CD cord-015021-pol2qm74 486 16 0 0 CD cord-015021-pol2qm74 486 17 m m NN cord-015021-pol2qm74 486 18 l l NN cord-015021-pol2qm74 486 19 / / SYM cord-015021-pol2qm74 486 20 k k NN cord-015021-pol2qm74 486 21 g g NN cord-015021-pol2qm74 486 22 h h NN cord-015021-pol2qm74 486 23 ) ) -RRB- cord-015021-pol2qm74 487 1 w w NNP cord-015021-pol2qm74 488 1 a a DT cord-015021-pol2qm74 488 2 s s NN cord-015021-pol2qm74 488 3 g g NN cord-015021-pol2qm74 489 1 i i PRP cord-015021-pol2qm74 489 2 v v NN cord-015021-pol2qm74 490 1 e e LS cord-015021-pol2qm74 490 2 n n NNP cord-015021-pol2qm74 490 3 intravenously intravenously RB cord-015021-pol2qm74 490 4 . . . cord-015021-pol2qm74 491 1 W w NN cord-015021-pol2qm74 491 2 h h NN cord-015021-pol2qm74 491 3 e e NN cord-015021-pol2qm74 491 4 n n NN cord-015021-pol2qm74 491 5 stabilised stabilise VBD cord-015021-pol2qm74 491 6 , , , cord-015021-pol2qm74 491 7 the the DT cord-015021-pol2qm74 491 8 a a NNP cord-015021-pol2qm74 491 9 n n NN cord-015021-pol2qm74 491 10 i i NN cord-015021-pol2qm74 491 11 m m NNP cord-015021-pol2qm74 491 12 a a NNP cord-015021-pol2qm74 491 13 l l NNP cord-015021-pol2qm74 491 14 s s NNP cord-015021-pol2qm74 491 15 w w NN cord-015021-pol2qm74 491 16 e e NN cord-015021-pol2qm74 491 17 r r NN cord-015021-pol2qm74 491 18 e e NN cord-015021-pol2qm74 491 19 g g NN cord-015021-pol2qm74 492 1 i i PRP cord-015021-pol2qm74 492 2 v v NN cord-015021-pol2qm74 493 1 e e LS cord-015021-pol2qm74 493 2 n n NN cord-015021-pol2qm74 493 3 2.5 2.5 CD cord-015021-pol2qm74 493 4 x x SYM cord-015021-pol2qm74 493 5 l09 l09 CD cord-015021-pol2qm74 493 6 CFU CFU NNP cord-015021-pol2qm74 493 7 of of IN cord-015021-pol2qm74 493 8 E E NNP cord-015021-pol2qm74 493 9 Colt Colt NNP cord-015021-pol2qm74 493 10 intraperitoneally intraperitoneally RB cord-015021-pol2qm74 493 11 as as IN cord-015021-pol2qm74 493 12 a a DT cord-015021-pol2qm74 493 13 bolus bolus NN cord-015021-pol2qm74 493 14 in in IN cord-015021-pol2qm74 493 15 100ml 100ml JJ cord-015021-pol2qm74 493 16 saline saline NN cord-015021-pol2qm74 493 17 , , , cord-015021-pol2qm74 493 18 the the DT cord-015021-pol2qm74 493 19 a a NN cord-015021-pol2qm74 493 20 n n NN cord-015021-pol2qm74 493 21 t t NN cord-015021-pol2qm74 493 22 i i NN cord-015021-pol2qm74 493 23 b b NN cord-015021-pol2qm74 493 24 o o NN cord-015021-pol2qm74 493 25 d d NN cord-015021-pol2qm74 494 1 y y NNP cord-015021-pol2qm74 494 2 g g NNP cord-015021-pol2qm74 494 3 r r NN cord-015021-pol2qm74 495 1 o o UH cord-015021-pol2qm74 495 2 u u NN cord-015021-pol2qm74 495 3 p p NN cord-015021-pol2qm74 495 4 received receive VBD cord-015021-pol2qm74 495 5 in in IN cord-015021-pol2qm74 495 6 a a DT cord-015021-pol2qm74 495 7 d d NN cord-015021-pol2qm74 495 8 d d NN cord-015021-pol2qm74 496 1 i i PRP cord-015021-pol2qm74 496 2 t t NNP cord-015021-pol2qm74 497 1 i i PRP cord-015021-pol2qm74 497 2 o o NN cord-015021-pol2qm74 497 3 n n NN cord-015021-pol2qm74 497 4 5 5 CD cord-015021-pol2qm74 497 5 m m NN cord-015021-pol2qm74 498 1 g g NNP cord-015021-pol2qm74 498 2 / / SYM cord-015021-pol2qm74 498 3 k k NNP cord-015021-pol2qm74 498 4 g g NN cord-015021-pol2qm74 498 5 E5 E5 NNP cord-015021-pol2qm74 498 6 a a DT cord-015021-pol2qm74 498 7 n n NN cord-015021-pol2qm74 498 8 t t NN cord-015021-pol2qm74 499 1 i i PRP cord-015021-pol2qm74 500 1 e e NNP cord-015021-pol2qm74 500 2 n n NN cord-015021-pol2qm74 500 3 d d NN cord-015021-pol2qm74 500 4 o o NN cord-015021-pol2qm74 501 1 t t NNP cord-015021-pol2qm74 502 1 o o UH cord-015021-pol2qm74 503 1 x x LS cord-015021-pol2qm74 504 1 i i PRP cord-015021-pol2qm74 505 1 n n NNP cord-015021-pol2qm74 505 2 i i NNP cord-015021-pol2qm74 505 3 n n NNP cord-015021-pol2qm74 506 1 t t NNP cord-015021-pol2qm74 506 2 r r NNP cord-015021-pol2qm74 506 3 a a NN cord-015021-pol2qm74 506 4 v v NN cord-015021-pol2qm74 506 5 e e NN cord-015021-pol2qm74 506 6 n n NN cord-015021-pol2qm74 506 7 o o NN cord-015021-pol2qm74 507 1 u u NNP cord-015021-pol2qm74 507 2 s s NNP cord-015021-pol2qm74 507 3 l l NNP cord-015021-pol2qm74 507 4 y y NNP cord-015021-pol2qm74 507 5 over over IN cord-015021-pol2qm74 507 6 1 1 CD cord-015021-pol2qm74 507 7 h h NN cord-015021-pol2qm74 507 8 o o NN cord-015021-pol2qm74 508 1 u u NNP cord-015021-pol2qm74 508 2 r r NNP cord-015021-pol2qm74 508 3 via via IN cord-015021-pol2qm74 508 4 a a DT cord-015021-pol2qm74 508 5 n n NN cord-015021-pol2qm74 508 6 infusion infusion NN cord-015021-pol2qm74 508 7 p p NN cord-015021-pol2qm74 508 8 u u NN cord-015021-pol2qm74 508 9 m m NN cord-015021-pol2qm74 508 10 p p NN cord-015021-pol2qm74 508 11 at at IN cord-015021-pol2qm74 508 12 the the DT cord-015021-pol2qm74 508 13 start start NN cord-015021-pol2qm74 508 14 of of IN cord-015021-pol2qm74 508 15 the the DT cord-015021-pol2qm74 508 16 observation observation NN cord-015021-pol2qm74 508 17 period period NN cord-015021-pol2qm74 508 18 . . . cord-015021-pol2qm74 509 1 The the DT cord-015021-pol2qm74 509 2 a a DT cord-015021-pol2qm74 509 3 n n NN cord-015021-pol2qm74 509 4 i i NN cord-015021-pol2qm74 509 5 m m NNP cord-015021-pol2qm74 509 6 a a NNP cord-015021-pol2qm74 509 7 l l NNP cord-015021-pol2qm74 509 8 s s NNP cord-015021-pol2qm74 509 9 w w NN cord-015021-pol2qm74 509 10 e e NN cord-015021-pol2qm74 509 11 r r NN cord-015021-pol2qm74 509 12 e e NNP cord-015021-pol2qm74 509 13 observed observe VBD cord-015021-pol2qm74 509 14 for for IN cord-015021-pol2qm74 509 15 6 6 CD cord-015021-pol2qm74 509 16 hours hour NNS cord-015021-pol2qm74 509 17 . . . cord-015021-pol2qm74 510 1 Results result NNS cord-015021-pol2qm74 510 2 : : : cord-015021-pol2qm74 511 1 A a DT cord-015021-pol2qm74 511 2 t t NN cord-015021-pol2qm74 511 3 5 5 CD cord-015021-pol2qm74 512 1 a a DT cord-015021-pol2qm74 512 2 n n NN cord-015021-pol2qm74 512 3 d d NN cord-015021-pol2qm74 512 4 6 6 CD cord-015021-pol2qm74 512 5 hours hour NNS cord-015021-pol2qm74 512 6 , , , cord-015021-pol2qm74 512 7 the the DT cord-015021-pol2qm74 512 8 o o NN cord-015021-pol2qm74 512 9 x x SYM cord-015021-pol2qm74 512 10 y y NNP cord-015021-pol2qm74 512 11 g g NN cord-015021-pol2qm74 512 12 e e NN cord-015021-pol2qm74 512 13 n n NN cord-015021-pol2qm74 512 14 c c NN cord-015021-pol2qm74 513 1 o o UH cord-015021-pol2qm74 513 2 n n NN cord-015021-pol2qm74 514 1 s s NNP cord-015021-pol2qm74 515 1 u u NNP cord-015021-pol2qm74 515 2 m m NN cord-015021-pol2qm74 515 3 p p NN cord-015021-pol2qm74 515 4 t t NN cord-015021-pol2qm74 516 1 i i PRP cord-015021-pol2qm74 516 2 o o NN cord-015021-pol2qm74 516 3 n n NN cord-015021-pol2qm74 516 4 increased increase VBD cord-015021-pol2qm74 516 5 by by IN cord-015021-pol2qm74 516 6 30 30 CD cord-015021-pol2qm74 516 7 % % NN cord-015021-pol2qm74 516 8 in in IN cord-015021-pol2qm74 516 9 the the DT cord-015021-pol2qm74 516 10 a a NNP cord-015021-pol2qm74 516 11 n n NN cord-015021-pol2qm74 516 12 t t NN cord-015021-pol2qm74 516 13 i i NN cord-015021-pol2qm74 516 14 b b NNP cord-015021-pol2qm74 516 15 o o NNP cord-015021-pol2qm74 516 16 d d NNP cord-015021-pol2qm74 516 17 y y NNP cord-015021-pol2qm74 516 18 treated treat VBD cord-015021-pol2qm74 516 19 g g NN cord-015021-pol2qm74 516 20 r r NN cord-015021-pol2qm74 516 21 o o NN cord-015021-pol2qm74 516 22 u u NN cord-015021-pol2qm74 516 23 p p NN cord-015021-pol2qm74 516 24 w w NN cord-015021-pol2qm74 516 25 h h NN cord-015021-pol2qm74 517 1 e e NNP cord-015021-pol2qm74 517 2 r r NNP cord-015021-pol2qm74 517 3 e e NNP cord-015021-pol2qm74 517 4 a a NNP cord-015021-pol2qm74 517 5 s s NN cord-015021-pol2qm74 517 6 there there RB cord-015021-pol2qm74 518 1 w w NNP cord-015021-pol2qm74 519 1 a a DT cord-015021-pol2qm74 519 2 s s NN cord-015021-pol2qm74 519 3 a a DT cord-015021-pol2qm74 519 4 significant significant JJ cord-015021-pol2qm74 519 5 fall fall NN cord-015021-pol2qm74 519 6 of of IN cord-015021-pol2qm74 519 7 30 30 CD cord-015021-pol2qm74 519 8 % % NN cord-015021-pol2qm74 519 9 in in IN cord-015021-pol2qm74 519 10 the the DT cord-015021-pol2qm74 519 11 sepsis sepsis NN cord-015021-pol2qm74 519 12 group group NN cord-015021-pol2qm74 519 13 . . . cord-015021-pol2qm74 520 1 In in IN cord-015021-pol2qm74 520 2 the the DT cord-015021-pol2qm74 520 3 a a NN cord-015021-pol2qm74 520 4 n n NN cord-015021-pol2qm74 520 5 t t NN cord-015021-pol2qm74 520 6 i i NN cord-015021-pol2qm74 520 7 b b NNP cord-015021-pol2qm74 520 8 o o NNP cord-015021-pol2qm74 520 9 d d NNP cord-015021-pol2qm74 520 10 y y NNP cord-015021-pol2qm74 520 11 group group NN cord-015021-pol2qm74 520 12 , , , cord-015021-pol2qm74 520 13 the the DT cord-015021-pol2qm74 520 14 arterial arterial JJ cord-015021-pol2qm74 520 15 p p NN cord-015021-pol2qm74 520 16 H h NN cord-015021-pol2qm74 520 17 a a NN cord-015021-pol2qm74 520 18 n n NN cord-015021-pol2qm74 520 19 d d NN cord-015021-pol2qm74 520 20 the the DT cord-015021-pol2qm74 520 21 cardiac cardiac JJ cord-015021-pol2qm74 520 22 index index NN cord-015021-pol2qm74 520 23 were be VBD cord-015021-pol2qm74 520 24 also also RB cord-015021-pol2qm74 520 25 significantly significantly RB cord-015021-pol2qm74 520 26 h h NN cord-015021-pol2qm74 521 1 i i PRP cord-015021-pol2qm74 522 1 g g NN cord-015021-pol2qm74 522 2 h h NN cord-015021-pol2qm74 522 3 e e NN cord-015021-pol2qm74 522 4 r r NN cord-015021-pol2qm74 522 5 at at IN cord-015021-pol2qm74 522 6 the the DT cord-015021-pol2qm74 522 7 s s NNP cord-015021-pol2qm74 522 8 a a NN cord-015021-pol2qm74 522 9 m m NN cord-015021-pol2qm74 522 10 e e NN cord-015021-pol2qm74 522 11 p p NN cord-015021-pol2qm74 522 12 o o UH cord-015021-pol2qm74 522 13 i i NN cord-015021-pol2qm74 522 14 n n CC cord-015021-pol2qm74 522 15 t t NNP cord-015021-pol2qm74 522 16 s s NNP cord-015021-pol2qm74 522 17 in in IN cord-015021-pol2qm74 522 18 time time NN cord-015021-pol2qm74 522 19 . . . cord-015021-pol2qm74 523 1 There there EX cord-015021-pol2qm74 523 2 w w IN cord-015021-pol2qm74 523 3 a a DT cord-015021-pol2qm74 523 4 s s NN cord-015021-pol2qm74 523 5 no no DT cord-015021-pol2qm74 523 6 significant significant JJ cord-015021-pol2qm74 523 7 difference difference NN cord-015021-pol2qm74 523 8 in in IN cord-015021-pol2qm74 523 9 arterial arterial JJ cord-015021-pol2qm74 523 10 pO2 po2 NN cord-015021-pol2qm74 523 11 . . . cord-015021-pol2qm74 524 1 In in IN cord-015021-pol2qm74 524 2 severe severe JJ cord-015021-pol2qm74 524 3 bacterial bacterial JJ cord-015021-pol2qm74 524 4 infections infection NNS cord-015021-pol2qm74 524 5 it -PRON- PRP cord-015021-pol2qm74 524 6 would would MD cord-015021-pol2qm74 524 7 be be VB cord-015021-pol2qm74 524 8 beneficial beneficial JJ cord-015021-pol2qm74 524 9 to to TO cord-015021-pol2qm74 524 10 neutralize neutralize VB cord-015021-pol2qm74 524 11 the the DT cord-015021-pol2qm74 524 12 plasma plasma NN cord-015021-pol2qm74 524 13 endotoxin endotoxin NN cord-015021-pol2qm74 524 14 content content NN cord-015021-pol2qm74 524 15 with with IN cord-015021-pol2qm74 524 16 complex complex JJ cord-015021-pol2qm74 524 17 forming form VBG cord-015021-pol2qm74 524 18 compounds compound NNS cord-015021-pol2qm74 524 19 . . . cord-015021-pol2qm74 525 1 The the DT cord-015021-pol2qm74 525 2 phenothiazines phenothiazine NNS cord-015021-pol2qm74 525 3 are be VBP cord-015021-pol2qm74 525 4 able able JJ cord-015021-pol2qm74 525 5 to to TO cord-015021-pol2qm74 525 6 form form VB cord-015021-pol2qm74 525 7 complexes complex NNS cord-015021-pol2qm74 525 8 with with IN cord-015021-pol2qm74 525 9 endoto×in endoto×in NNP cord-015021-pol2qm74 525 10 and and CC cord-015021-pol2qm74 525 11 the the DT cord-015021-pol2qm74 525 12 existence existence NN cord-015021-pol2qm74 525 13 of of IN cord-015021-pol2qm74 525 14 these these DT cord-015021-pol2qm74 525 15 complexes complex NNS cord-015021-pol2qm74 525 16 were be VBD cord-015021-pol2qm74 525 17 already already RB cord-015021-pol2qm74 525 18 shown show VBN cord-015021-pol2qm74 525 19 in in IN cord-015021-pol2qm74 525 20 differential differential JJ cord-015021-pol2qm74 525 21 speetrophotometry speetrophotometry NNP cord-015021-pol2qm74 525 22 and and CC cord-015021-pol2qm74 525 23 animal animal NN cord-015021-pol2qm74 525 24 experiments experiment NNS cord-015021-pol2qm74 525 25 , , , cord-015021-pol2qm74 525 26 however however RB cord-015021-pol2qm74 525 27 , , , cord-015021-pol2qm74 525 28 the the DT cord-015021-pol2qm74 525 29 mechanism mechanism NN cord-015021-pol2qm74 525 30 of of IN cord-015021-pol2qm74 525 31 partial partial JJ cord-015021-pol2qm74 525 32 neutralization neutralization NN cord-015021-pol2qm74 525 33 was be VBD cord-015021-pol2qm74 525 34 not not RB cord-015021-pol2qm74 525 35 clarified clarify VBN cord-015021-pol2qm74 525 36 . . . cord-015021-pol2qm74 526 1 Therefore therefore RB cord-015021-pol2qm74 526 2 some some DT cord-015021-pol2qm74 526 3 representative representative JJ cord-015021-pol2qm74 526 4 phenothiazines phenothiazine NNS cord-015021-pol2qm74 526 5 and and CC cord-015021-pol2qm74 526 6 structurally structurally RB cord-015021-pol2qm74 526 7 related related JJ cord-015021-pol2qm74 526 8 compounds compound NNS cord-015021-pol2qm74 526 9 were be VBD cord-015021-pol2qm74 526 10 tested test VBN cord-015021-pol2qm74 526 11 for for IN cord-015021-pol2qm74 526 12 anti anti JJ cord-015021-pol2qm74 526 13 - - JJ cord-015021-pol2qm74 526 14 endotoxin endotoxin JJ cord-015021-pol2qm74 526 15 activity activity NN cord-015021-pol2qm74 526 16 . . . cord-015021-pol2qm74 527 1 The the DT cord-015021-pol2qm74 527 2 endotoxin endotoxin NN cord-015021-pol2qm74 527 3 neutralizinB neutralizinB NNP cord-015021-pol2qm74 527 4 effects effect NNS cord-015021-pol2qm74 527 5 of of IN cord-015021-pol2qm74 527 6 several several JJ cord-015021-pol2qm74 527 7 benzophenothiazines benzophenothiazine NNS cord-015021-pol2qm74 527 8 were be VBD cord-015021-pol2qm74 527 9 investigated investigate VBN cord-015021-pol2qm74 527 10 in in IN cord-015021-pol2qm74 527 11 differential differential JJ cord-015021-pol2qm74 527 12 speotrophotemetry speotrophotemetry NNP cord-015021-pol2qm74 527 13 , , , cord-015021-pol2qm74 527 14 TNF TNF NNP cord-015021-pol2qm74 527 15 induction induction NN cord-015021-pol2qm74 527 16 and and CC cord-015021-pol2qm74 527 17 in in IN cord-015021-pol2qm74 527 18 the the DT cord-015021-pol2qm74 527 19 conventional conventional JJ cord-015021-pol2qm74 527 20 Limulus Limulus NNP cord-015021-pol2qm74 527 21 test test NN cord-015021-pol2qm74 527 22 . . . cord-015021-pol2qm74 528 1 In in IN cord-015021-pol2qm74 528 2 animal animal NN cord-015021-pol2qm74 528 3 experiments experiment NNS cord-015021-pol2qm74 528 4 some some DT cord-015021-pol2qm74 528 5 beneficial beneficial JJ cord-015021-pol2qm74 528 6 effect effect NN cord-015021-pol2qm74 528 7 of of IN cord-015021-pol2qm74 528 8 complex complex JJ cord-015021-pol2qm74 528 9 forming form VBG cord-015021-pol2qm74 528 10 compounds compound NNS cord-015021-pol2qm74 528 11 was be VBD cord-015021-pol2qm74 528 12 found find VBN cord-015021-pol2qm74 528 13 . . . cord-015021-pol2qm74 529 1 The the DT cord-015021-pol2qm74 529 2 benzophenothiazines benzophenothiazine NNS cord-015021-pol2qm74 529 3 were be VBD cord-015021-pol2qm74 529 4 not not RB cord-015021-pol2qm74 529 5 able able JJ cord-015021-pol2qm74 529 6 to to TO cord-015021-pol2qm74 529 7 inactivate inactivate VB cord-015021-pol2qm74 529 8 the the DT cord-015021-pol2qm74 529 9 biological biological JJ cord-015021-pol2qm74 529 10 effect effect NN cord-015021-pol2qm74 529 11 of of IN cord-015021-pol2qm74 529 12 endotoxin endotoxin NN cord-015021-pol2qm74 529 13 in in IN cord-015021-pol2qm74 529 14 the the DT cord-015021-pol2qm74 529 15 Limulus Limulus NNP cord-015021-pol2qm74 529 16 test test NN cord-015021-pol2qm74 529 17 . . . cord-015021-pol2qm74 530 1 The the DT cord-015021-pol2qm74 530 2 recent recent JJ cord-015021-pol2qm74 530 3 findings finding NNS cord-015021-pol2qm74 530 4 indicates indicate VBZ cord-015021-pol2qm74 530 5 that that IN cord-015021-pol2qm74 530 6 a a DT cord-015021-pol2qm74 530 7 multifocal multifocal JJ cord-015021-pol2qm74 530 8 effect effect NN cord-015021-pol2qm74 530 9 can can MD cord-015021-pol2qm74 530 10 be be VB cord-015021-pol2qm74 530 11 responsible responsible JJ cord-015021-pol2qm74 530 12 for for IN cord-015021-pol2qm74 530 13 " " `` cord-015021-pol2qm74 530 14 anti anti JJ cord-015021-pol2qm74 530 15 - - JJ cord-015021-pol2qm74 530 16 endotoxin endotoxin JJ cord-015021-pol2qm74 530 17 action action NN cord-015021-pol2qm74 530 18 in in IN cord-015021-pol2qm74 530 19 vivo vivo NN cord-015021-pol2qm74 530 20 " " '' cord-015021-pol2qm74 530 21 . . . cord-015021-pol2qm74 531 1 Effects effect NNS cord-015021-pol2qm74 531 2 of of IN cord-015021-pol2qm74 531 3 TNF tnf NN cord-015021-pol2qm74 531 4 inducing induce VBG cord-015021-pol2qm74 531 5 effect effect NN cord-015021-pol2qm74 531 6 of of IN cord-015021-pol2qm74 531 7 endotoxin endotoxin NN cord-015021-pol2qm74 531 8 in in IN cord-015021-pol2qm74 531 9 leukocytes leukocyte NNS cord-015021-pol2qm74 531 10 and and CC cord-015021-pol2qm74 531 11 bypotensiv bypotensiv JJ cord-015021-pol2qm74 531 12 action action NN cord-015021-pol2qm74 531 13 in in IN cord-015021-pol2qm74 531 14 experimental experimental JJ cord-015021-pol2qm74 531 15 animals animal NNS cord-015021-pol2qm74 531 16 were be VBD cord-015021-pol2qm74 531 17 reduced reduce VBN cord-015021-pol2qm74 531 18 by by IN cord-015021-pol2qm74 531 19 some some DT cord-015021-pol2qm74 531 20 phenothiazine phenothiazine NN cord-015021-pol2qm74 531 21 derivatives derivative NNS cord-015021-pol2qm74 531 22 . . . cord-015021-pol2qm74 532 1 Monophosphoril Monophosphoril NNP cord-015021-pol2qm74 532 2 lipid lipid NN cord-015021-pol2qm74 532 3 A A NNP cord-015021-pol2qm74 532 4 was be VBD cord-015021-pol2qm74 532 5 without without IN cord-015021-pol2qm74 532 6 effect effect NN cord-015021-pol2qm74 532 7 . . . cord-015021-pol2qm74 533 1 of of IN cord-015021-pol2qm74 533 2 Microbiology Microbiology NNP cord-015021-pol2qm74 533 3 , , , cord-015021-pol2qm74 533 4 Albert Albert NNP cord-015021-pol2qm74 533 5 Szemt Szemt NNP cord-015021-pol2qm74 533 6 - - HYPH cord-015021-pol2qm74 533 7 GydrByi GydrByi NNP cord-015021-pol2qm74 533 8 Medical Medical NNP cord-015021-pol2qm74 533 9 University University NNP cord-015021-pol2qm74 533 10 , , , cord-015021-pol2qm74 534 1 Odm Odm NNP cord-015021-pol2qm74 534 2 t t NN cord-015021-pol2qm74 535 1 ~r ~r NNP cord-015021-pol2qm74 535 2 lO lO NNP cord-015021-pol2qm74 535 3 , , , cord-015021-pol2qm74 536 1 H-6720 H-6720 NNP cord-015021-pol2qm74 536 2 Szeged~ Szeged~ . cord-015021-pol2qm74 537 1 HunBary hunbary CD cord-015021-pol2qm74 537 2 46 46 CD cord-015021-pol2qm74 537 3 Involvement Involvement NNP cord-015021-pol2qm74 537 4 of of IN cord-015021-pol2qm74 537 5 Streptococcus streptococcus NN cord-015021-pol2qm74 537 6 pyogenes pyogene NNS cord-015021-pol2qm74 537 7 Erythrogenic Erythrogenic NNP cord-015021-pol2qm74 537 8 Toxins toxin NNS cord-015021-pol2qm74 537 9 in in IN cord-015021-pol2qm74 537 10 the the DT cord-015021-pol2qm74 537 11 Induction Induction NNP cord-015021-pol2qm74 537 12 OflStreptococcal OflStreptococcal NNP cord-015021-pol2qm74 537 13 Toxic Toxic NNP cord-015021-pol2qm74 537 14 Shock Shock NNP cord-015021-pol2qm74 537 15 Syndrome Syndrome NNP cord-015021-pol2qm74 537 16 3 3 CD cord-015021-pol2qm74 538 1 Heide Heide NNP cord-015021-pol2qm74 538 2 Mgller Mgller NNP cord-015021-pol2qm74 538 3 - - HYPH cord-015021-pol2qm74 538 4 Alou~ Alou~ NNP cord-015021-pol2qm74 539 1 * * NFP cord-015021-pol2qm74 539 2 , , , cord-015021-pol2qm74 539 3 Joseph Joseph NNP cord-015021-pol2qm74 539 4 E. E. NNP cord-015021-pol2qm74 539 5 Alouf Alouf NNP cord-015021-pol2qm74 539 6 , , , cord-015021-pol2qm74 539 7 Die die VB cord-015021-pol2qm74 539 8 [ [ -LRB- cord-015021-pol2qm74 539 9 er er UH cord-015021-pol2qm74 539 10 Gerlach Gerlach NNP cord-015021-pol2qm74 539 11 , , , cord-015021-pol2qm74 539 12 ~atherine ~atherine NNP cord-015021-pol2qm74 539 13 Fitting Fitting NNP cord-015021-pol2qm74 539 14 . . . cord-015021-pol2qm74 539 15 , , , cord-015021-pol2qm74 539 16 and and CC cord-015021-pol2qm74 539 17 Jean Jean NNP cord-015021-pol2qm74 539 18 - - HYPH cord-015021-pol2qm74 539 19 Marc Marc NNP cord-015021-pol2qm74 539 20 Ca Ca NNP cord-015021-pol2qm74 539 21 ~ ~ NFP cord-015021-pol2qm74 539 22 aillon aillon NNP cord-015021-pol2qm74 539 23 . . . cord-015021-pol2qm74 540 1 Unit6 Unit6 NNP cord-015021-pol2qm74 540 2 des des NNP cord-015021-pol2qm74 540 3 Toxines Toxines NNP cord-015021-pol2qm74 540 4 Microbiennes Microbiennes NNPS cord-015021-pol2qm74 540 5 and and CC cord-015021-pol2qm74 540 6 " " `` cord-015021-pol2qm74 540 7 Unit6 unit6 JJ cord-015021-pol2qm74 540 8 d'Immuno d'Immuno NNP cord-015021-pol2qm74 540 9 - - HYPH cord-015021-pol2qm74 540 10 Allergie Allergie NNP cord-015021-pol2qm74 540 11 , , , cord-015021-pol2qm74 540 12 Institut Institut NNP cord-015021-pol2qm74 540 13 Pasteur Pasteur NNP cord-015021-pol2qm74 540 14 , , , cord-015021-pol2qm74 540 15 28 28 CD cord-015021-pol2qm74 540 16 , , , cord-015021-pol2qm74 540 17 rue rue FW cord-015021-pol2qm74 540 18 du du FW cord-015021-pol2qm74 540 19 Docteur Docteur NNP cord-015021-pol2qm74 540 20 Roux Roux NNP cord-015021-pol2qm74 540 21 -75015 -75015 VBZ cord-015021-pol2qm74 540 22 PARIS PARIS NNP cord-015021-pol2qm74 540 23 ( ( -LRB- cord-015021-pol2qm74 540 24 France France NNP cord-015021-pol2qm74 540 25 ) ) -RRB- cord-015021-pol2qm74 540 26 ; ; : cord-015021-pol2qm74 540 27 Institut Institut NNP cord-015021-pol2qm74 540 28 f f NNP cord-015021-pol2qm74 541 1 ~r ~r XX cord-015021-pol2qm74 541 2 Experimentelle Experimentelle NNP cord-015021-pol2qm74 541 3 Mikrobiologie Mikrobiologie NNP cord-015021-pol2qm74 541 4 , , , cord-015021-pol2qm74 541 5 JENA JENA NNP cord-015021-pol2qm74 541 6 ( ( -LRB- cord-015021-pol2qm74 541 7 Germany Germany NNP cord-015021-pol2qm74 541 8 ) ) -RRB- cord-015021-pol2qm74 541 9 . . . cord-015021-pol2qm74 542 1 superantigen superantigen NNP cord-015021-pol2qm74 542 2 erythrogenic erythrogenic NNP cord-015021-pol2qm74 542 3 toxin toxin NN cord-015021-pol2qm74 542 4 A a NN cord-015021-pol2qm74 542 5 ( ( -LRB- cord-015021-pol2qm74 542 6 ETA ETA NNP cord-015021-pol2qm74 542 7 ) ) -RRB- cord-015021-pol2qm74 542 8 is be VBZ cord-015021-pol2qm74 542 9 thought think VBN cord-015021-pol2qm74 542 10 to to TO cord-015021-pol2qm74 542 11 be be VB cord-015021-pol2qm74 542 12 involved involve VBN cord-015021-pol2qm74 542 13 in in IN cord-015021-pol2qm74 542 14 toxic toxic JJ cord-015021-pol2qm74 542 15 shock shock NN cord-015021-pol2qm74 542 16 syndrome syndrome NN cord-015021-pol2qm74 542 17 in in IN cord-015021-pol2qm74 542 18 humans human NNS cord-015021-pol2qm74 542 19 by by IN cord-015021-pol2qm74 542 20 inducing induce VBG cord-015021-pol2qm74 542 21 massive massive JJ cord-015021-pol2qm74 542 22 release release NN cord-015021-pol2qm74 542 23 of of IN cord-015021-pol2qm74 542 24 cytokines cytokine NNS cord-015021-pol2qm74 542 25 by by IN cord-015021-pol2qm74 542 26 patient patient JJ cord-015021-pol2qm74 542 27 immune immune JJ cord-015021-pol2qm74 542 28 cells cell NNS cord-015021-pol2qm74 542 29 . . . cord-015021-pol2qm74 543 1 The the DT cord-015021-pol2qm74 543 2 cytokineinducing cytokineinducing NN cord-015021-pol2qm74 543 3 capacity capacity NN cord-015021-pol2qm74 543 4 of of IN cord-015021-pol2qm74 543 5 ETA ETA NNP cord-015021-pol2qm74 543 6 w~:s w~:s '' cord-015021-pol2qm74 543 7 £ £ NN cord-015021-pol2qm74 543 8 : : : cord-015021-pol2qm74 543 9 ompa ompa NNP cord-015021-pol2qm74 543 10 ~ ~ NFP cord-015021-pol2qm74 543 11 ed ed NN cord-015021-pol2qm74 543 12 to to IN cord-015021-pol2qm74 543 13 that that DT cord-015021-pol2qm74 543 14 of of IN cord-015021-pol2qm74 543 15 LPS LPS NNP cord-015021-pol2qm74 543 16 , , , cord-015021-pol2qm74 543 17 a a DT cord-015021-pol2qm74 543 18 gram gram NN cord-015021-pol2qm74 543 19 - - HYPH cord-015021-pol2qm74 543 20 negative negative JJ cord-015021-pol2qm74 543 21 bacterial bacterial JJ cord-015021-pol2qm74 543 22 cell cell NN cord-015021-pol2qm74 543 23 wall wall NN cord-015021-pol2qm74 543 24 component component NN cord-015021-pol2qm74 543 25 . . . cord-015021-pol2qm74 544 1 ETA ETA NNP cord-015021-pol2qm74 544 2 elicited elicit VBD cord-015021-pol2qm74 544 3 weak weak JJ cord-015021-pol2qm74 544 4 production production NN cord-015021-pol2qm74 544 5 of of IN cord-015021-pol2qm74 544 6 IL-1 IL-1 NNP cord-015021-pol2qm74 544 7 d d NNP cord-015021-pol2qm74 544 8 and and CC cord-015021-pol2qm74 544 9 ~ ~ NNP cord-015021-pol2qm74 544 10 , , , cord-015021-pol2qm74 544 11 TNF TNF NNP cord-015021-pol2qm74 544 12 ~ ~ NFP cord-015021-pol2qm74 544 13 and and CC cord-015021-pol2qm74 544 14 IL-6 IL-6 NNP cord-015021-pol2qm74 544 15 in in IN cord-015021-pol2qm74 544 16 purified purify VBN cord-015021-pol2qm74 544 17 human human JJ cord-015021-pol2qm74 544 18 monocytes monocyte NNS cord-015021-pol2qm74 544 19 whereas whereas IN cord-015021-pol2qm74 544 20 LPS lp NNS cord-015021-pol2qm74 544 21 stimulated stimulate VBD cord-015021-pol2qm74 544 22 the the DT cord-015021-pol2qm74 544 23 production production NN cord-015021-pol2qm74 544 24 of of IN cord-015021-pol2qm74 544 25 high high JJ cord-015021-pol2qm74 544 26 amounts amount NNS cord-015021-pol2qm74 544 27 of of IN cord-015021-pol2qm74 544 28 these these DT cord-015021-pol2qm74 544 29 cytokines cytokine NNS cord-015021-pol2qm74 544 30 . . . cord-015021-pol2qm74 545 1 In in IN cord-015021-pol2qm74 545 2 the the DT cord-015021-pol2qm74 545 3 presence presence NN cord-015021-pol2qm74 545 4 of of IN cord-015021-pol2qm74 545 5 T T NNP cord-015021-pol2qm74 545 6 cells cell NNS cord-015021-pol2qm74 545 7 , , , cord-015021-pol2qm74 545 8 ETA ETA NNP cord-015021-pol2qm74 545 9 elicited elicit VBD cord-015021-pol2qm74 545 10 the the DT cord-015021-pol2qm74 545 11 production production NN cord-015021-pol2qm74 545 12 of of IN cord-015021-pol2qm74 545 13 significant significant JJ cord-015021-pol2qm74 545 14 amounts amount NNS cord-015021-pol2qm74 545 15 of of IN cord-015021-pol2qm74 545 16 IL IL NNP cord-015021-pol2qm74 545 17 - - HYPH cord-015021-pol2qm74 545 18 I~ I~ NNP cord-015021-pol2qm74 545 19 , , , cord-015021-pol2qm74 545 20 IL IL NNP cord-015021-pol2qm74 545 21 - - HYPH cord-015021-pol2qm74 545 22 I~ I~ NNP cord-015021-pol2qm74 545 23 , , , cord-015021-pol2qm74 545 24 IL-6 IL-6 NNP cord-015021-pol2qm74 545 25 and and CC cord-015021-pol2qm74 545 26 IL-8 IL-8 NNP cord-015021-pol2qm74 545 27 . . . cord-015021-pol2qm74 546 1 However however RB cord-015021-pol2qm74 546 2 , , , cord-015021-pol2qm74 546 3 the the DT cord-015021-pol2qm74 546 4 most most RBS cord-015021-pol2qm74 546 5 preponderant preponderant JJ cord-015021-pol2qm74 546 6 cytokine cytokine NN cord-015021-pol2qm74 546 7 was be VBD cord-015021-pol2qm74 546 8 TNF~ tnf~ RB cord-015021-pol2qm74 546 9 , , , cord-015021-pol2qm74 546 10 which which WDT cord-015021-pol2qm74 546 11 peaked peak VBD cord-015021-pol2qm74 546 12 at at IN cord-015021-pol2qm74 546 13 i0 i0 NNP cord-015021-pol2qm74 546 14 ng ng NNP cord-015021-pol2qm74 546 15 / / SYM cord-015021-pol2qm74 546 16 ml ml NN cord-015021-pol2qm74 546 17 after after IN cord-015021-pol2qm74 546 18 stimulation stimulation NN cord-015021-pol2qm74 546 19 with with IN cord-015021-pol2qm74 546 20 i0 i0 NNP cord-015021-pol2qm74 546 21 ~g ~g NNP cord-015021-pol2qm74 546 22 ETA ETA NNP cord-015021-pol2qm74 546 23 . . . cord-015021-pol2qm74 547 1 Comparable comparable JJ cord-015021-pol2qm74 547 2 amounts amount NNS cord-015021-pol2qm74 547 3 of of IN cord-015021-pol2qm74 547 4 TNFd TNFd NNS cord-015021-pol2qm74 547 5 ( ( -LRB- cord-015021-pol2qm74 547 6 ca ca NNP cord-015021-pol2qm74 547 7 4 4 CD cord-015021-pol2qm74 547 8 ng ng NNP cord-015021-pol2qm74 547 9 ) ) -RRB- cord-015021-pol2qm74 547 10 were be VBD cord-015021-pol2qm74 547 11 induced induce VBN cord-015021-pol2qm74 547 12 by by IN cord-015021-pol2qm74 547 13 0.i 0.i CD cord-015021-pol2qm74 548 1 ~g ~g NNP cord-015021-pol2qm74 549 1 ETA ETA NNP cord-015021-pol2qm74 549 2 and and CC cord-015021-pol2qm74 549 3 0.i 0.i CD cord-015021-pol2qm74 550 1 ~g ~g NNP cord-015021-pol2qm74 551 1 LP$. LP$. NNP cord-015021-pol2qm74 552 1 In in IN cord-015021-pol2qm74 552 2 contrast contrast NN cord-015021-pol2qm74 552 3 to to IN cord-015021-pol2qm74 552 4 LPS LPS NNP cord-015021-pol2qm74 552 5 , , , cord-015021-pol2qm74 552 6 ETA ETA NNP cord-015021-pol2qm74 552 7 was be VBD cord-015021-pol2qm74 552 8 a a DT cord-015021-pol2qm74 552 9 strong strong JJ cord-015021-pol2qm74 552 10 inducer inducer NN cord-015021-pol2qm74 552 11 of of IN cord-015021-pol2qm74 552 12 TNF~ tnf~ CD cord-015021-pol2qm74 552 13 which which WDT cord-015021-pol2qm74 552 14 was be VBD cord-015021-pol2qm74 552 15 produced produce VBN cord-015021-pol2qm74 552 16 only only RB cord-015021-pol2qm74 552 17 in in IN cord-015021-pol2qm74 552 18 marginal marginal JJ cord-015021-pol2qm74 552 19 amounts amount NNS cord-015021-pol2qm74 552 20 by by IN cord-015021-pol2qm74 552 21 LPS lp NNS cord-015021-pol2qm74 552 22 . . . cord-015021-pol2qm74 553 1 These these DT cord-015021-pol2qm74 553 2 results result NNS cord-015021-pol2qm74 553 3 suggest suggest VBP cord-015021-pol2qm74 553 4 that that IN cord-015021-pol2qm74 553 5 the the DT cord-015021-pol2qm74 553 6 septic septic JJ cord-015021-pol2qm74 553 7 shock shock NN cord-015021-pol2qm74 553 8 induced induce VBN cord-015021-pol2qm74 553 9 by by IN cord-015021-pol2qm74 553 10 gramnegative gramnegative JJ cord-015021-pol2qm74 553 11 bacteria bacteria NNS cord-015021-pol2qm74 553 12 ( ( -LRB- cord-015021-pol2qm74 553 13 LPS LPS NNP cord-015021-pol2qm74 553 14 ) ) -RRB- cord-015021-pol2qm74 553 15 and and CC cord-015021-pol2qm74 553 16 by by IN cord-015021-pol2qm74 553 17 gram gram NN cord-015021-pol2qm74 553 18 - - HYPH cord-015021-pol2qm74 553 19 positive positive JJ cord-015021-pol2qm74 553 20 bacteria bacteria NNS cord-015021-pol2qm74 553 21 { { -LRB- cord-015021-pol2qm74 553 22 extracellular extracellular JJ cord-015021-pol2qm74 553 23 superantigens superantigen NNS cord-015021-pol2qm74 553 24 ) ) -RRB- cord-015021-pol2qm74 553 25 follows follow VBZ cord-015021-pol2qm74 553 26 different different JJ cord-015021-pol2qm74 553 27 pathogenic pathogenic JJ cord-015021-pol2qm74 553 28 pathways pathway NNS cord-015021-pol2qm74 553 29 . . . cord-015021-pol2qm74 554 1 LPS LPS NNP cord-015021-pol2qm74 554 2 - - HYPH cord-015021-pol2qm74 554 3 induced induce VBN cord-015021-pol2qm74 554 4 shock shock NN cord-015021-pol2qm74 554 5 is be VBZ cord-015021-pol2qm74 554 6 mainly mainly RB cord-015021-pol2qm74 554 7 mediated mediate VBN cord-015021-pol2qm74 554 8 by by IN cord-015021-pol2qm74 554 9 monocytes monocyte NNS cord-015021-pol2qm74 554 10 and and CC cord-015021-pol2qm74 554 11 monocyte monocyte NNP cord-015021-pol2qm74 554 12 - - HYPH cord-015021-pol2qm74 554 13 produced produce VBN cord-015021-pol2qm74 554 14 cytokines cytokine NNS cord-015021-pol2qm74 555 1 ( ( -LRB- cord-015021-pol2qm74 555 2 IL IL NNP cord-015021-pol2qm74 555 3 - - HYPH cord-015021-pol2qm74 555 4 I I NNP cord-015021-pol2qm74 555 5 and and CC cord-015021-pol2qm74 555 6 TNF TNF NNP cord-015021-pol2qm74 555 7 ) ) -RRB- cord-015021-pol2qm74 555 8 . . . cord-015021-pol2qm74 556 1 The the DT cord-015021-pol2qm74 556 2 ETA ETA NNP cord-015021-pol2qm74 556 3 - - HYPH cord-015021-pol2qm74 556 4 induced induce VBN cord-015021-pol2qm74 556 5 shock shock NN cord-015021-pol2qm74 556 6 is be VBZ cord-015021-pol2qm74 556 7 mediated mediate VBN cord-015021-pol2qm74 556 8 by by IN cord-015021-pol2qm74 556 9 T T NNP cord-015021-pol2qm74 556 10 - - HYPH cord-015021-pol2qm74 556 11 cells cell NNS cord-015021-pol2qm74 556 12 or or CC cord-015021-pol2qm74 556 13 depends depend VBZ cord-015021-pol2qm74 556 14 on on IN cord-015021-pol2qm74 556 15 T T NNP cord-015021-pol2qm74 556 16 cell cell NN cord-015021-pol2qm74 556 17 help help NN cord-015021-pol2qm74 556 18 for for IN cord-015021-pol2qm74 556 19 the the DT cord-015021-pol2qm74 556 20 production production NN cord-015021-pol2qm74 556 21 of of IN cord-015021-pol2qm74 556 22 monocyte monocyte NNP cord-015021-pol2qm74 556 23 - - HYPH cord-015021-pol2qm74 556 24 liberated liberate VBN cord-015021-pol2qm74 556 25 cytokines cytokine NNS cord-015021-pol2qm74 556 26 . . . cord-015021-pol2qm74 557 1 Production production NN cord-015021-pol2qm74 557 2 of of IN cord-015021-pol2qm74 557 3 T T NNP cord-015021-pol2qm74 557 4 cell cell NN cord-015021-pol2qm74 557 5 cytokines cytokine NNS cord-015021-pol2qm74 557 6 such such JJ cord-015021-pol2qm74 557 7 as as IN cord-015021-pol2qm74 557 8 TNF~ tnf~ CD cord-015021-pol2qm74 557 9 and and CC cord-015021-pol2qm74 557 10 interferon interferon NN cord-015021-pol2qm74 557 11 7 7 CD cord-015021-pol2qm74 557 12 in in IN cord-015021-pol2qm74 557 13 addition addition NN cord-015021-pol2qm74 557 14 to to IN cord-015021-pol2qm74 557 15 the the DT cord-015021-pol2qm74 557 16 other other JJ cord-015021-pol2qm74 557 17 cytokines cytokine NNS cord-015021-pol2qm74 557 18 contribute contribute VBP cord-015021-pol2qm74 557 19 very very RB cord-015021-pol2qm74 557 20 likely likely JJ cord-015021-pol2qm74 557 21 to to IN cord-015021-pol2qm74 557 22 the the DT cord-015021-pol2qm74 557 23 severity severity NN cord-015021-pol2qm74 557 24 of of IN cord-015021-pol2qm74 557 25 the the DT cord-015021-pol2qm74 557 26 toxic toxic JJ cord-015021-pol2qm74 557 27 - - HYPH cord-015021-pol2qm74 557 28 shock shock NN cord-015021-pol2qm74 557 29 resulting result VBG cord-015021-pol2qm74 557 30 from from IN cord-015021-pol2qm74 557 31 S. S. NNP cord-015021-pol2qm74 557 32 auzeus auzeu NNS cord-015021-pol2qm74 557 33 and and CC cord-015021-pol2qm74 557 34 S. S. NNP cord-015021-pol2qm74 557 35 pyogenes pyogene NNS cord-015021-pol2qm74 557 36 infections infection NNS cord-015021-pol2qm74 557 37 in in IN cord-015021-pol2qm74 557 38 humans human NNS cord-015021-pol2qm74 557 39 . . . cord-015021-pol2qm74 558 1 The the DT cord-015021-pol2qm74 558 2 present present JJ cord-015021-pol2qm74 558 3 study study NN cord-015021-pol2qm74 558 4 was be VBD cord-015021-pol2qm74 558 5 utidertakc utidertakc NNS cord-015021-pol2qm74 558 6 ~ ~ NNP cord-015021-pol2qm74 558 7 l l NNP cord-015021-pol2qm74 558 8 to to IN cord-015021-pol2qm74 558 9 cvalu cvalu NNP cord-015021-pol2qm74 559 1 ~tlc ~tlc VB cord-015021-pol2qm74 559 2 the the DT cord-015021-pol2qm74 559 3 effect effect NN cord-015021-pol2qm74 559 4 of of IN cord-015021-pol2qm74 559 5 soluble soluble JJ cord-015021-pol2qm74 559 6 chemically chemically RB cord-015021-pol2qm74 559 7 modified modify VBN cord-015021-pol2qm74 559 8 giucan giucan NN cord-015021-pol2qm74 559 9 during during IN cord-015021-pol2qm74 559 10 septic septic JJ cord-015021-pol2qm74 559 11 shock shock NN cord-015021-pol2qm74 559 12 . . . cord-015021-pol2qm74 560 1 Carboxylnethyl Carboxylnethyl NNP cord-015021-pol2qm74 560 2 - - HYPH cord-015021-pol2qm74 560 3 b b NN cord-015021-pol2qm74 560 4 - - : cord-015021-pol2qm74 560 5 i,3-glucan i,3-glucan NN cord-015021-pol2qm74 561 1 ( ( -LRB- cord-015021-pol2qm74 561 2 ram ram VB cord-015021-pol2qm74 561 3 120000 120000 CD cord-015021-pol2qm74 561 4 ) ) -RRB- cord-015021-pol2qm74 561 5 was be VBD cord-015021-pol2qm74 561 6 injected inject VBN cord-015021-pol2qm74 561 7 twice twice RB cord-015021-pol2qm74 561 8 48 48 CD cord-015021-pol2qm74 561 9 and and CC cord-015021-pol2qm74 561 10 24 24 CD cord-015021-pol2qm74 561 11 h h NN cord-015021-pol2qm74 561 12 before before IN cord-015021-pol2qm74 561 13 the the DT cord-015021-pol2qm74 561 14 shock shock NN cord-015021-pol2qm74 561 15 i.v i.v NNP cord-015021-pol2qm74 561 16 . . . cord-015021-pol2qm74 562 1 in in IN cord-015021-pol2qm74 562 2 a a DT cord-015021-pol2qm74 562 3 dose dose NN cord-015021-pol2qm74 562 4 of of IN cord-015021-pol2qm74 562 5 50 50 CD cord-015021-pol2qm74 562 6 ing ing NN cord-015021-pol2qm74 562 7 / / SYM cord-015021-pol2qm74 562 8 kg kg NN cord-015021-pol2qm74 562 9 . . . cord-015021-pol2qm74 563 1 Shock shock NN cord-015021-pol2qm74 563 2 was be VBD cord-015021-pol2qm74 563 3 induced induce VBN cord-015021-pol2qm74 563 4 in in IN cord-015021-pol2qm74 563 5 u~?esthetizcd u~?esthetizcd NNP cord-015021-pol2qm74 563 6 ( ( -LRB- cord-015021-pol2qm74 563 7 sodikm~. sodikm~. NNP cord-015021-pol2qm74 563 8 l)mntobarbital l)mntobarbital CD cord-015021-pol2qm74 563 9 ) ) -RRB- cord-015021-pol2qm74 563 10 rats rat NNS cord-015021-pol2qm74 563 11 by by IN cord-015021-pol2qm74 563 12 i.v i.v NNP cord-015021-pol2qm74 563 13 . . NNP cord-015021-pol2qm74 563 14 injection injection NN cord-015021-pol2qm74 563 15 of of IN cord-015021-pol2qm74 563 16 endotoxin endotoxin NN cord-015021-pol2qm74 563 17 of of IN cord-015021-pol2qm74 563 18 Escherichia Escherichia NNP cord-015021-pol2qm74 563 19 colli colli NNP cord-015021-pol2qm74 563 20 0127 0127 CD cord-015021-pol2qm74 563 21 BS BS NNP cord-015021-pol2qm74 563 22 , , , cord-015021-pol2qm74 563 23 5 5 CD cord-015021-pol2qm74 563 24 mg mg NNP cord-015021-pol2qm74 563 25 / / SYM cord-015021-pol2qm74 563 26 kg kg NN cord-015021-pol2qm74 563 27 . . . cord-015021-pol2qm74 564 1 AIIofCMG AIIofCMG NNP cord-015021-pol2qm74 564 2 pretreated pretreate VBD cord-015021-pol2qm74 564 3 ruts rut NNS cord-015021-pol2qm74 564 4 survived survive VBD cord-015021-pol2qm74 564 5 during during IN cord-015021-pol2qm74 564 6 first first JJ cord-015021-pol2qm74 564 7 24haher 24haher CD cord-015021-pol2qm74 564 8 ¢ndotoxine ¢ndotoxine NN cord-015021-pol2qm74 564 9 , , , cord-015021-pol2qm74 564 10 while while IN cord-015021-pol2qm74 564 11 in in IN cord-015021-pol2qm74 564 12 controi controi NNP cord-015021-pol2qm74 564 13 shock shock NN cord-015021-pol2qm74 564 14 group group NN cord-015021-pol2qm74 564 15 the the DT cord-015021-pol2qm74 564 16 lethality lethality NN cord-015021-pol2qm74 564 17 was be VBD cord-015021-pol2qm74 564 18 90 90 CD cord-015021-pol2qm74 564 19 % % NN cord-015021-pol2qm74 564 20 . . . cord-015021-pol2qm74 565 1 The the DT cord-015021-pol2qm74 565 2 concentration concentration NN cord-015021-pol2qm74 565 3 of of IN cord-015021-pol2qm74 565 4 ~col)terin ~col)terin NN cord-015021-pol2qm74 565 5 in in IN cord-015021-pol2qm74 565 6 serum serum NN cord-015021-pol2qm74 565 7 was be VBD cord-015021-pol2qm74 565 8 significantly significantly RB cord-015021-pol2qm74 565 9 elevated elevate VBN cord-015021-pol2qm74 565 10 24 24 CD cord-015021-pol2qm74 565 11 hafterthc hafterthc NN cord-015021-pol2qm74 565 12 second second NN cord-015021-pol2qm74 565 13 CMGinjection CMGinjection NNP cord-015021-pol2qm74 566 1 ( ( -LRB- cord-015021-pol2qm74 566 2 appare appare NNP cord-015021-pol2qm74 566 3 ~ ~ NFP cord-015021-pol2qm74 566 4 tly tly RB cord-015021-pol2qm74 566 5 80 80 CD cord-015021-pol2qm74 566 6 % % NN cord-015021-pol2qm74 566 7 if if IN cord-015021-pol2qm74 566 8 compare compare VBP cord-015021-pol2qm74 566 9 with with IN cord-015021-pol2qm74 566 10 the the DT cord-015021-pol2qm74 566 11 control control NN cord-015021-pol2qm74 566 12 rats rat NNS cord-015021-pol2qm74 566 13 ) ) -RRB- cord-015021-pol2qm74 566 14 , , , cord-015021-pol2qm74 566 15 but but CC cord-015021-pol2qm74 566 16 didu't didu't NNS cord-015021-pol2qm74 566 17 chartged chartge VBD cord-015021-pol2qm74 566 18 60 60 CD cord-015021-pol2qm74 566 19 rain rain NN cord-015021-pol2qm74 566 20 and and CC cord-015021-pol2qm74 566 21 1 1 CD cord-015021-pol2qm74 566 22 S0 s0 NN cord-015021-pol2qm74 566 23 rain rain NN cord-015021-pol2qm74 566 24 after after IN cord-015021-pol2qm74 566 25 endotoxin endotoxin NN cord-015021-pol2qm74 566 26 injectJom injectJom VBN cord-015021-pol2qm74 566 27 Cardiac cardiac JJ cord-015021-pol2qm74 566 28 output output NN cord-015021-pol2qm74 566 29 in in IN cord-015021-pol2qm74 566 30 CMOgroup CMOgroup NNP cord-015021-pol2qm74 566 31 was be VBD cord-015021-pol2qm74 566 32 higher high JJR cord-015021-pol2qm74 567 1 a a LS cord-015021-pol2qm74 567 2 * * NFP cord-015021-pol2qm74 567 3 the the DT cord-015021-pol2qm74 567 4 i20 i20 NNP cord-015021-pol2qm74 567 5 and and CC cord-015021-pol2qm74 567 6 180 180 CD cord-015021-pol2qm74 567 7 min min NN cord-015021-pol2qm74 567 8 after after IN cord-015021-pol2qm74 567 9 endotoxine endotoxine JJ cord-015021-pol2qm74 567 10 onset onset NN cord-015021-pol2qm74 567 11 ( ( -LRB- cord-015021-pol2qm74 567 12 8I 8i CD cord-015021-pol2qm74 567 13 % % NN cord-015021-pol2qm74 567 14 trod tread VBD cord-015021-pol2qm74 567 15 72~ 72~ CD cord-015021-pol2qm74 567 16 , , , cord-015021-pol2qm74 567 17 respectively respectively RB cord-015021-pol2qm74 567 18 of of IN cord-015021-pol2qm74 567 19 initial initial JJ cord-015021-pol2qm74 567 20 level level NN cord-015021-pol2qm74 567 21 ) ) -RRB- cord-015021-pol2qm74 568 1 than than IN cord-015021-pol2qm74 568 2 in in IN cord-015021-pol2qm74 568 3 the the DT cord-015021-pol2qm74 568 4 control control NN cord-015021-pol2qm74 568 5 shock shock NN cord-015021-pol2qm74 568 6 group group NN cord-015021-pol2qm74 568 7 ( ( -LRB- cord-015021-pol2qm74 568 8 64 64 CD cord-015021-pol2qm74 568 9 % % NN cord-015021-pol2qm74 568 10 and and CC cord-015021-pol2qm74 568 11 52 52 CD cord-015021-pol2qm74 568 12 % % NN cord-015021-pol2qm74 568 13 at at IN cord-015021-pol2qm74 568 14 the the DT cord-015021-pol2qm74 568 15 same same JJ cord-015021-pol2qm74 568 16 time time NN cord-015021-pol2qm74 568 17 ) ) -RRB- cord-015021-pol2qm74 568 18 . . . cord-015021-pol2qm74 569 1 Pretreatment pretreatment NN cord-015021-pol2qm74 569 2 of of IN cord-015021-pol2qm74 569 3 rals ral NNS cord-015021-pol2qm74 569 4 with with IN cord-015021-pol2qm74 569 5 soh soh NNP cord-015021-pol2qm74 569 6 ~ ~ NFP cord-015021-pol2qm74 569 7 ble ble NNP cord-015021-pol2qm74 569 8 gIucan gIucan NNP cord-015021-pol2qm74 569 9 w w NN cord-015021-pol2qm74 569 10 ~ ~ NFP cord-015021-pol2qm74 569 11 ts ts NNP cord-015021-pol2qm74 569 12 associated associate VBN cord-015021-pol2qm74 569 13 with with IN cord-015021-pol2qm74 569 14 beneficial beneficial JJ cord-015021-pol2qm74 569 15 effects effect NNS cord-015021-pol2qm74 569 16 o~ o~ XX cord-015021-pol2qm74 569 17 the the DT cord-015021-pol2qm74 569 18 hepatic hepatic JJ cord-015021-pol2qm74 569 19 c c NN cord-015021-pol2qm74 569 20 ~ ~ NFP cord-015021-pol2qm74 569 21 ergy ergy NNP cord-015021-pol2qm74 570 1 $ $ $ cord-015021-pol2qm74 570 2 Ia[tlS Ia[tlS NNP cord-015021-pol2qm74 570 3 after after IN cord-015021-pol2qm74 570 4 3 3 CD cord-015021-pol2qm74 570 5 h h NN cord-015021-pol2qm74 570 6 after after IN cord-015021-pol2qm74 570 7 challenge challenge NN cord-015021-pol2qm74 570 8 of of IN cord-015021-pol2qm74 570 9 endotoxiae endotoxiae NNP cord-015021-pol2qm74 570 10 : : : cord-015021-pol2qm74 570 11 the the DT cord-015021-pol2qm74 570 12 tissue tissue NN cord-015021-pol2qm74 570 13 level level NN cord-015021-pol2qm74 570 14 of of IN cord-015021-pol2qm74 570 15 lactale lactale NN cord-015021-pol2qm74 570 16 was be VBD cord-015021-pol2qm74 570 17 ahnost ahnost NN cord-015021-pol2qm74 570 18 twice twice RB cord-015021-pol2qm74 570 19 lower low JJR cord-015021-pol2qm74 570 20 than than IN cord-015021-pol2qm74 570 21 in in IN cord-015021-pol2qm74 570 22 the the DT cord-015021-pol2qm74 570 23 control control NN cord-015021-pol2qm74 570 24 ruts rut NNS cord-015021-pol2qm74 570 25 , , , cord-015021-pol2qm74 570 26 me -PRON- PRP cord-015021-pol2qm74 570 27 ~ ~ NFP cord-015021-pol2qm74 570 28 mthne mthne NNP cord-015021-pol2qm74 570 29 the the DT cord-015021-pol2qm74 570 30 tissue tissue NN cord-015021-pol2qm74 570 31 ATF ATF NNP cord-015021-pol2qm74 570 32 in in IN cord-015021-pol2qm74 570 33 CMG CMG NNP cord-015021-pol2qm74 570 34 pretreated pretreate VBD cord-015021-pol2qm74 570 35 group group NN cord-015021-pol2qm74 570 36 was be VBD cord-015021-pol2qm74 570 37 higher high JJR cord-015021-pol2qm74 570 38 at at IN cord-015021-pol2qm74 570 39 40 40 CD cord-015021-pol2qm74 570 40 % % NN cord-015021-pol2qm74 570 41 . . . cord-015021-pol2qm74 571 1 Twice twice RB cord-015021-pol2qm74 571 2 injected inject VBN cord-015021-pol2qm74 571 3 macrophage macrophage NN cord-015021-pol2qm74 571 4 stimuhttor stimuhttor NN cord-015021-pol2qm74 571 5 soluble soluble JJ cord-015021-pol2qm74 571 6 glucan glucan NN cord-015021-pol2qm74 571 7 can can MD cord-015021-pol2qm74 571 8 prevent prevent VB cord-015021-pol2qm74 571 9 the the DT cord-015021-pol2qm74 571 10 endotoxic endotoxic JJ cord-015021-pol2qm74 571 11 shock shock NN cord-015021-pol2qm74 571 12 , , , cord-015021-pol2qm74 571 13 and and CC cord-015021-pol2qm74 571 14 extremely extremely RB cord-015021-pol2qm74 571 15 ir ir NNP cord-015021-pol2qm74 571 16 ~ ~ NFP cord-015021-pol2qm74 571 17 creased crease VBN cord-015021-pol2qm74 571 18 survival survival NN cord-015021-pol2qm74 571 19 rate rate NN cord-015021-pol2qm74 571 20 after after IN cord-015021-pol2qm74 571 21 endotoxine endotoxine NNP cord-015021-pol2qm74 571 22 injection injection NN cord-015021-pol2qm74 571 23 . . . cord-015021-pol2qm74 572 1 The the DT cord-015021-pol2qm74 572 2 National National NNP cord-015021-pol2qm74 572 3 Committee Committee NNP cord-015021-pol2qm74 572 4 of of IN cord-015021-pol2qm74 572 5 Surgical Surgical NNP cord-015021-pol2qm74 572 6 Infections Infections NNPS cord-015021-pol2qm74 572 7 of of IN cord-015021-pol2qm74 572 8 the the DT cord-015021-pol2qm74 572 9 Spanish Spanish NNP cord-015021-pol2qm74 572 10 Association Association NNP cord-015021-pol2qm74 572 11 of of IN cord-015021-pol2qm74 572 12 Surgeons Surgeons NNPS cord-015021-pol2qm74 572 13 have have VBP cord-015021-pol2qm74 572 14 produced produce VBN cord-015021-pol2qm74 572 15 a a DT cord-015021-pol2qm74 572 16 computer computer NN cord-015021-pol2qm74 572 17 program program NN cord-015021-pol2qm74 572 18 for for IN cord-015021-pol2qm74 572 19 the the DT cord-015021-pol2qm74 572 20 collection collection NN cord-015021-pol2qm74 572 21 and and CC cord-015021-pol2qm74 572 22 analysis analysis NN cord-015021-pol2qm74 572 23 of of IN cord-015021-pol2qm74 572 24 information information NN cord-015021-pol2qm74 572 25 on on IN cord-015021-pol2qm74 572 26 surgical surgical JJ cord-015021-pol2qm74 572 27 infections infection NNS cord-015021-pol2qm74 572 28 . . . cord-015021-pol2qm74 573 1 The the DT cord-015021-pol2qm74 573 2 program program NN cord-015021-pol2qm74 573 3 is be VBZ cord-015021-pol2qm74 573 4 suitable suitable JJ cord-015021-pol2qm74 573 5 for for IN cord-015021-pol2qm74 573 6 IBM IBM NNP cord-015021-pol2qm74 573 7 compatible compatible JJ cord-015021-pol2qm74 573 8 hard hard JJ cord-015021-pol2qm74 573 9 disk disk NN cord-015021-pol2qm74 573 10 personal personal JJ cord-015021-pol2qm74 573 11 computers computer NNS cord-015021-pol2qm74 573 12 and and CC cord-015021-pol2qm74 573 13 works work VBZ cord-015021-pol2qm74 573 14 through through IN cord-015021-pol2qm74 573 15 the the DT cord-015021-pol2qm74 573 16 MS MS NNP cord-015021-pol2qm74 573 17 - - HYPH cord-015021-pol2qm74 573 18 DOS DOS NNP cord-015021-pol2qm74 573 19 system system NN cord-015021-pol2qm74 573 20 . . . cord-015021-pol2qm74 574 1 The the DT cord-015021-pol2qm74 574 2 main main JJ cord-015021-pol2qm74 574 3 menu menu NN cord-015021-pol2qm74 574 4 is be VBZ cord-015021-pol2qm74 574 5 called call VBN cord-015021-pol2qm74 574 6 up up RP cord-015021-pol2qm74 574 7 on on IN cord-015021-pol2qm74 574 8 the the DT cord-015021-pol2qm74 574 9 screen screen NN cord-015021-pol2qm74 574 10 when when WRB cord-015021-pol2qm74 574 11 the the DT cord-015021-pol2qm74 574 12 operating operating NN cord-015021-pol2qm74 574 13 disk disk NN cord-015021-pol2qm74 574 14 has have VBZ cord-015021-pol2qm74 574 15 been be VBN cord-015021-pol2qm74 574 16 installed instal VBN cord-015021-pol2qm74 574 17 ; ; : cord-015021-pol2qm74 574 18 it -PRON- PRP cord-015021-pol2qm74 574 19 reads read VBZ cord-015021-pol2qm74 574 20 as as IN cord-015021-pol2qm74 574 21 follows follow VBZ cord-015021-pol2qm74 574 22 : : : cord-015021-pol2qm74 575 1 I. I. NNP cord-015021-pol2qm74 575 2 New New NNP cord-015021-pol2qm74 575 3 record record NN cord-015021-pol2qm74 575 4 ; ; : cord-015021-pol2qm74 575 5 2 2 CD cord-015021-pol2qm74 575 6 . . . cord-015021-pol2qm74 576 1 Modify modify VB cord-015021-pol2qm74 576 2 records record NNS cord-015021-pol2qm74 576 3 ; ; : cord-015021-pol2qm74 576 4 3 3 CD cord-015021-pol2qm74 576 5 . . . cord-015021-pol2qm74 577 1 Erase erase VB cord-015021-pol2qm74 577 2 records record NNS cord-015021-pol2qm74 577 3 ; ; : cord-015021-pol2qm74 577 4 4 4 CD cord-015021-pol2qm74 577 5 . . . cord-015021-pol2qm74 578 1 Searches search NNS cord-015021-pol2qm74 578 2 ; ; : cord-015021-pol2qm74 578 3 5 5 CD cord-015021-pol2qm74 578 4 . . . cord-015021-pol2qm74 579 1 Reports report NNS cord-015021-pol2qm74 579 2 ; ; : cord-015021-pol2qm74 579 3 6 6 CD cord-015021-pol2qm74 579 4 . . . cord-015021-pol2qm74 580 1 Configure configure VB cord-015021-pol2qm74 580 2 ; ; : cord-015021-pol2qm74 580 3 O. O. NNP cord-015021-pol2qm74 580 4 Ouit Ouit NNP cord-015021-pol2qm74 580 5 . . . cord-015021-pol2qm74 581 1 If if IN cord-015021-pol2qm74 581 2 you -PRON- PRP cord-015021-pol2qm74 581 3 ask ask VBP cord-015021-pol2qm74 581 4 fdr fdr NNP cord-015021-pol2qm74 581 5 a a DT cord-015021-pol2qm74 581 6 new new JJ cord-015021-pol2qm74 581 7 record record NN cord-015021-pol2qm74 581 8 the the DT cord-015021-pol2qm74 581 9 screen screen NN cord-015021-pol2qm74 581 10 will will MD cord-015021-pol2qm74 581 11 prompt prompt VB cord-015021-pol2qm74 581 12 you -PRON- PRP cord-015021-pol2qm74 581 13 to to TO cord-015021-pol2qm74 581 14 enter enter VB cord-015021-pol2qm74 581 15 the the DT cord-015021-pol2qm74 581 16 number number NN cord-015021-pol2qm74 581 17 of of IN cord-015021-pol2qm74 581 18 case case NN cord-015021-pol2qm74 581 19 , , , cord-015021-pol2qm74 581 20 record record NN cord-015021-pol2qm74 581 21 number number NN cord-015021-pol2qm74 581 22 , , , cord-015021-pol2qm74 581 23 hospital hospital NN cord-015021-pol2qm74 581 24 , , , cord-015021-pol2qm74 581 25 age age NN cord-015021-pol2qm74 581 26 and and CC cord-015021-pol2qm74 581 27 sex sex NN cord-015021-pol2qm74 581 28 . . . cord-015021-pol2qm74 582 1 The the DT cord-015021-pol2qm74 582 2 next next JJ cord-015021-pol2qm74 582 3 screen screen NN cord-015021-pol2qm74 582 4 will will MD cord-015021-pol2qm74 582 5 come come VB cord-015021-pol2qm74 582 6 up up RP cord-015021-pol2qm74 582 7 and and CC cord-015021-pol2qm74 582 8 the the DT cord-015021-pol2qm74 582 9 words word NNS cord-015021-pol2qm74 582 10 " " `` cord-015021-pol2qm74 582 11 Topographic topographic JJ cord-015021-pol2qm74 582 12 diagnosis diagnosis NN cord-015021-pol2qm74 582 13 " " '' cord-015021-pol2qm74 582 14 will will MD cord-015021-pol2qm74 582 15 flash flash VB cord-015021-pol2qm74 582 16 . . . cord-015021-pol2qm74 583 1 A a DT cord-015021-pol2qm74 583 2 menu menu NN cord-015021-pol2qm74 583 3 of of IN cord-015021-pol2qm74 583 4 34 34 CD cord-015021-pol2qm74 583 5 areas area NNS cord-015021-pol2qm74 583 6 or or CC cord-015021-pol2qm74 583 7 organs organ NNS cord-015021-pol2qm74 583 8 will will MD cord-015021-pol2qm74 583 9 be be VB cord-015021-pol2qm74 583 10 displayed display VBN cord-015021-pol2qm74 583 11 . . . cord-015021-pol2qm74 584 1 Then then RB cord-015021-pol2qm74 584 2 , , , cord-015021-pol2qm74 584 3 the the DT cord-015021-pol2qm74 584 4 words word NNS cord-015021-pol2qm74 584 5 " " `` cord-015021-pol2qm74 584 6 Type type NN cord-015021-pol2qm74 584 7 of of IN cord-015021-pol2qm74 584 8 pathology pathology NN cord-015021-pol2qm74 584 9 " " '' cord-015021-pol2qm74 584 10 ( ( -LRB- cord-015021-pol2qm74 584 11 inflammatory inflammatory JJ cord-015021-pol2qm74 584 12 , , , cord-015021-pol2qm74 584 13 neoplastic neoplastic JJ cord-015021-pol2qm74 584 14 , , , cord-015021-pol2qm74 584 15 traumatic traumatic JJ cord-015021-pol2qm74 584 16 and and CC cord-015021-pol2qm74 584 17 other other JJ cord-015021-pol2qm74 584 18 ) ) -RRB- cord-015021-pol2qm74 584 19 . . . cord-015021-pol2qm74 585 1 Days day NNS cord-015021-pol2qm74 585 2 of of IN cord-015021-pol2qm74 585 3 postoperative postoperative JJ cord-015021-pol2qm74 585 4 period period NN cord-015021-pol2qm74 585 5 . . . cord-015021-pol2qm74 586 1 Type type NN cord-015021-pol2qm74 586 2 of of IN cord-015021-pol2qm74 586 3 surgery surgery NN cord-015021-pol2qm74 586 4 ( ( -LRB- cord-015021-pol2qm74 586 5 programmed program VBN cord-015021-pol2qm74 586 6 and and CC cord-015021-pol2qm74 586 7 emergency emergency NN cord-015021-pol2qm74 586 8 ) ) -RRB- cord-015021-pol2qm74 586 9 . . . cord-015021-pol2qm74 587 1 Type type NN cord-015021-pol2qm74 587 2 of of IN cord-015021-pol2qm74 587 3 operation operation NN cord-015021-pol2qm74 587 4 ( ( -LRB- cord-015021-pol2qm74 587 5 clean clean JJ cord-015021-pol2qm74 587 6 , , , cord-015021-pol2qm74 587 7 clean clean JJ cord-015021-pol2qm74 587 8 contaminated contaminate VBN cord-015021-pol2qm74 587 9 , , , cord-015021-pol2qm74 587 10 contaminated contaminated JJ cord-015021-pol2qm74 587 11 and and CC cord-015021-pol2qm74 587 12 dirty dirty JJ cord-015021-pol2qm74 587 13 ) ) -RRB- cord-015021-pol2qm74 587 14 . . . cord-015021-pol2qm74 588 1 Duration duration NN cord-015021-pol2qm74 588 2 of of IN cord-015021-pol2qm74 588 3 surgery surgery NN cord-015021-pol2qm74 588 4 . . . cord-015021-pol2qm74 589 1 This this DT cord-015021-pol2qm74 589 2 is be VBZ cord-015021-pol2qm74 589 3 followed follow VBN cord-015021-pol2qm74 589 4 by by IN cord-015021-pol2qm74 589 5 " " `` cord-015021-pol2qm74 589 6 Order order NN cord-015021-pol2qm74 589 7 of of IN cord-015021-pol2qm74 589 8 operation operation NN cord-015021-pol2qm74 589 9 " " '' cord-015021-pol2qm74 589 10 and and CC cord-015021-pol2qm74 589 11 the the DT cord-015021-pol2qm74 589 12 " " `` cord-015021-pol2qm74 589 13 Type type NN cord-015021-pol2qm74 589 14 of of IN cord-015021-pol2qm74 589 15 anaesthesia anaesthesia NN cord-015021-pol2qm74 589 16 ( ( -LRB- cord-015021-pol2qm74 589 17 general general JJ cord-015021-pol2qm74 589 18 , , , cord-015021-pol2qm74 589 19 regional regional JJ cord-015021-pol2qm74 589 20 or or CC cord-015021-pol2qm74 589 21 local local JJ cord-015021-pol2qm74 589 22 ) ) -RRB- cord-015021-pol2qm74 589 23 . . . cord-015021-pol2qm74 590 1 You -PRON- PRP cord-015021-pol2qm74 590 2 are be VBP cord-015021-pol2qm74 590 3 then then RB cord-015021-pol2qm74 590 4 required require VBN cord-015021-pol2qm74 590 5 to to TO cord-015021-pol2qm74 590 6 supply supply VB cord-015021-pol2qm74 590 7 the the DT cord-015021-pol2qm74 590 8 " " `` cord-015021-pol2qm74 590 9 Diagnostic diagnostic JJ cord-015021-pol2qm74 590 10 code code NN cord-015021-pol2qm74 590 11 of of IN cord-015021-pol2qm74 590 12 WHO who WP cord-015021-pol2qm74 590 13 " " '' cord-015021-pol2qm74 590 14 ( ( -LRB- cord-015021-pol2qm74 590 15 ICD9 ICD9 NNP cord-015021-pol2qm74 590 16 ) ) -RRB- cord-015021-pol2qm74 590 17 and and CC cord-015021-pol2qm74 590 18 the the DT cord-015021-pol2qm74 590 19 " " `` cord-015021-pol2qm74 590 20 Procedure procedure NN cord-015021-pol2qm74 590 21 code code NN cord-015021-pol2qm74 590 22 of of IN cord-015021-pol2qm74 590 23 WHO WHO NNP cord-015021-pol2qm74 590 24 . . . cord-015021-pol2qm74 591 1 Analytic analytic JJ cord-015021-pol2qm74 591 2 and and CC cord-015021-pol2qm74 591 3 concurrent concurrent JJ cord-015021-pol2qm74 591 4 illnesses illness NNS cord-015021-pol2qm74 591 5 ( ( -LRB- cord-015021-pol2qm74 591 6 total total JJ cord-015021-pol2qm74 591 7 proteins protein NNS cord-015021-pol2qm74 591 8 , , , cord-015021-pol2qm74 591 9 albumin albumin NN cord-015021-pol2qm74 591 10 , , , cord-015021-pol2qm74 591 11 haemoglobin haemoglobin NN cord-015021-pol2qm74 591 12 , , , cord-015021-pol2qm74 591 13 haematocrit haematocrit NNP cord-015021-pol2qm74 591 14 , , , cord-015021-pol2qm74 591 15 leucocytes leucocytes NNP cord-015021-pol2qm74 591 16 , , , cord-015021-pol2qm74 591 17 red red JJ cord-015021-pol2qm74 591 18 corpuscles corpuscle NNS cord-015021-pol2qm74 591 19 , , , cord-015021-pol2qm74 591 20 glucose glucose NN cord-015021-pol2qm74 591 21 and and CC cord-015021-pol2qm74 591 22 bilirubin bilirubin NN cord-015021-pol2qm74 591 23 ) ) -RRB- cord-015021-pol2qm74 591 24 . . . cord-015021-pol2qm74 592 1 The the DT cord-015021-pol2qm74 592 2 next next JJ cord-015021-pol2qm74 592 3 screen screen NN cord-015021-pol2qm74 592 4 asks ask VBZ cord-015021-pol2qm74 592 5 for for IN cord-015021-pol2qm74 592 6 " " `` cord-015021-pol2qm74 592 7 Risk risk NN cord-015021-pol2qm74 592 8 factors factor NNS cord-015021-pol2qm74 592 9 " " '' cord-015021-pol2qm74 592 10 ( ( -LRB- cord-015021-pol2qm74 592 11 obesity obesity NN cord-015021-pol2qm74 592 12 , , , cord-015021-pol2qm74 592 13 uraemia uraemia NN cord-015021-pol2qm74 592 14 , , , cord-015021-pol2qm74 592 15 neoplasia neoplasia NN cord-015021-pol2qm74 592 16 , , , cord-015021-pol2qm74 592 17 malnutrition malnutrition NN cord-015021-pol2qm74 592 18 , , , cord-015021-pol2qm74 592 19 urinary urinary JJ cord-015021-pol2qm74 592 20 catheter catheter NN cord-015021-pol2qm74 592 21 , , , cord-015021-pol2qm74 592 22 distant distant JJ cord-015021-pol2qm74 592 23 infection infection NN cord-015021-pol2qm74 592 24 , , , cord-015021-pol2qm74 592 25 artificial artificial JJ cord-015021-pol2qm74 592 26 valve valve NN cord-015021-pol2qm74 592 27 , , , cord-015021-pol2qm74 592 28 immunosuppressive immunosuppressive JJ cord-015021-pol2qm74 592 29 drugs drug NNS cord-015021-pol2qm74 592 30 , , , cord-015021-pol2qm74 592 31 over over IN cord-015021-pol2qm74 592 32 65 65 CD cord-015021-pol2qm74 592 33 years year NNS cord-015021-pol2qm74 592 34 and and CC cord-015021-pol2qm74 592 35 anergy anergy NNP cord-015021-pol2qm74 592 36 . . . cord-015021-pol2qm74 593 1 This this DT cord-015021-pol2qm74 593 2 is be VBZ cord-015021-pol2qm74 593 3 followed follow VBN cord-015021-pol2qm74 593 4 by by IN cord-015021-pol2qm74 593 5 a a DT cord-015021-pol2qm74 593 6 screen screen NN cord-015021-pol2qm74 593 7 headed head VBN cord-015021-pol2qm74 593 8 " " `` cord-015021-pol2qm74 593 9 Postoperative postoperative JJ cord-015021-pol2qm74 593 10 complications complication NNS cord-015021-pol2qm74 593 11 " " '' cord-015021-pol2qm74 593 12 . . . cord-015021-pol2qm74 594 1 " " `` cord-015021-pol2qm74 594 2 Evolution evolution NN cord-015021-pol2qm74 594 3 " " '' cord-015021-pol2qm74 594 4 ( ( -LRB- cord-015021-pol2qm74 594 5 the the DT cord-015021-pol2qm74 594 6 questions question NNS cord-015021-pol2qm74 594 7 asked ask VBN cord-015021-pol2qm74 594 8 are be VBP cord-015021-pol2qm74 594 9 drainage drainage NN cord-015021-pol2qm74 594 10 , , , cord-015021-pol2qm74 594 11 systemic systemic JJ cord-015021-pol2qm74 594 12 antibiotics antibiotic NNS cord-015021-pol2qm74 594 13 , , , cord-015021-pol2qm74 594 14 and and CC cord-015021-pol2qm74 594 15 on on IN cord-015021-pol2qm74 594 16 each each DT cord-015021-pol2qm74 594 17 ocasion ocasion NN cord-015021-pol2qm74 594 18 a a DT cord-015021-pol2qm74 594 19 choice choice NN cord-015021-pol2qm74 594 20 of of IN cord-015021-pol2qm74 594 21 31 31 CD cord-015021-pol2qm74 594 22 antibiotics antibiotic NNS cord-015021-pol2qm74 594 23 is be VBZ cord-015021-pol2qm74 594 24 displayed display VBN cord-015021-pol2qm74 594 25 ) ) -RRB- cord-015021-pol2qm74 594 26 , , , cord-015021-pol2qm74 594 27 local local JJ cord-015021-pol2qm74 594 28 antiseptics antiseptic NNS cord-015021-pol2qm74 594 29 , , , cord-015021-pol2qm74 594 30 reoperation reoperation NN cord-015021-pol2qm74 594 31 , , , cord-015021-pol2qm74 594 32 etc etc FW cord-015021-pol2qm74 594 33 . . . cord-015021-pol2qm74 595 1 Under under IN cord-015021-pol2qm74 595 2 " " `` cord-015021-pol2qm74 595 3 Microhiology Microhiology NNP cord-015021-pol2qm74 595 4 " " '' cord-015021-pol2qm74 595 5 is be VBZ cord-015021-pol2qm74 595 6 a a DT cord-015021-pol2qm74 595 7 choice choice NN cord-015021-pol2qm74 595 8 of of IN cord-015021-pol2qm74 595 9 37 37 CD cord-015021-pol2qm74 595 10 organisms organism NNS cord-015021-pol2qm74 595 11 and and CC cord-015021-pol2qm74 595 12 the the DT cord-015021-pol2qm74 595 13 chance chance NN cord-015021-pol2qm74 595 14 of of IN cord-015021-pol2qm74 595 15 identifyin identifyin NNP cord-015021-pol2qm74 595 16 3 3 CD cord-015021-pol2qm74 595 17 organisms organism NNS cord-015021-pol2qm74 595 18 . . . cord-015021-pol2qm74 596 1 Finally finally RB cord-015021-pol2qm74 596 2 , , , cord-015021-pol2qm74 596 3 " " `` cord-015021-pol2qm74 596 4 Sepsis sepsis NN cord-015021-pol2qm74 596 5 score score NN cord-015021-pol2qm74 596 6 " " '' cord-015021-pol2qm74 596 7 . . . cord-015021-pol2qm74 597 1 Our -PRON- PRP$ cord-015021-pol2qm74 597 2 recent recent JJ cord-015021-pol2qm74 597 3 work work NN cord-015021-pol2qm74 597 4 had have VBD cord-015021-pol2qm74 597 5 shown show VBN cord-015021-pol2qm74 597 6 that that IN cord-015021-pol2qm74 597 7 RenShen RenShen NNP cord-015021-pol2qm74 597 8 - - HYPH cord-015021-pol2qm74 597 9 Fuzi Fuzi NNP cord-015021-pol2qm74 597 10 - - HYPH cord-015021-pol2qm74 597 11 ChaiHu ChaiHu NNS cord-015021-pol2qm74 597 12 mixture mixture NN cord-015021-pol2qm74 597 13 could could MD cord-015021-pol2qm74 597 14 increase increase VB cord-015021-pol2qm74 597 15 the the DT cord-015021-pol2qm74 597 16 survival survival NN cord-015021-pol2qm74 597 17 rate rate NN cord-015021-pol2qm74 597 18 in in IN cord-015021-pol2qm74 597 19 experimented experiment VBN cord-015021-pol2qm74 597 20 study study NN cord-015021-pol2qm74 597 21 . . . cord-015021-pol2qm74 598 1 The the DT cord-015021-pol2qm74 598 2 purpose purpose NN cord-015021-pol2qm74 598 3 of of IN cord-015021-pol2qm74 598 4 this this DT cord-015021-pol2qm74 598 5 study study NN cord-015021-pol2qm74 598 6 was be VBD cord-015021-pol2qm74 598 7 to to TO cord-015021-pol2qm74 598 8 determine determine VB cord-015021-pol2qm74 598 9 the the DT cord-015021-pol2qm74 598 10 effect effect NN cord-015021-pol2qm74 598 11 of of IN cord-015021-pol2qm74 598 12 combined combined JJ cord-015021-pol2qm74 598 13 administration administration NN cord-015021-pol2qm74 598 14 of of IN cord-015021-pol2qm74 598 15 RenShen RenShen NNP cord-015021-pol2qm74 598 16 - - HYPH cord-015021-pol2qm74 598 17 Fuzi Fuzi NNP cord-015021-pol2qm74 598 18 - - HYPH cord-015021-pol2qm74 598 19 ChaiHu ChaiHu NNS cord-015021-pol2qm74 598 20 mixtuer mixtuer NNP cord-015021-pol2qm74 598 21 and and CC cord-015021-pol2qm74 598 22 Antibitics Antibitics NNP cord-015021-pol2qm74 598 23 ( ( -LRB- cord-015021-pol2qm74 598 24 SA SA NNP cord-015021-pol2qm74 598 25 ) ) -RRB- cord-015021-pol2qm74 598 26 in in IN cord-015021-pol2qm74 598 27 patients patient NNS cord-015021-pol2qm74 598 28 with with IN cord-015021-pol2qm74 598 29 septic septic JJ cord-015021-pol2qm74 598 30 shock shock NN cord-015021-pol2qm74 598 31 . . . cord-015021-pol2qm74 599 1 The the DT cord-015021-pol2qm74 599 2 result result NN cord-015021-pol2qm74 599 3 showed show VBD cord-015021-pol2qm74 599 4 that that IN cord-015021-pol2qm74 599 5 , , , cord-015021-pol2qm74 599 6 in in IN cord-015021-pol2qm74 599 7 SA SA NNP cord-015021-pol2qm74 599 8 group group NN cord-015021-pol2qm74 599 9 ( ( -LRB- cord-015021-pol2qm74 599 10 40 40 CD cord-015021-pol2qm74 599 11 cases case NNS cord-015021-pol2qm74 599 12 ) ) -RRB- cord-015021-pol2qm74 599 13 , , , cord-015021-pol2qm74 599 14 the the DT cord-015021-pol2qm74 599 15 total total JJ cord-015021-pol2qm74 599 16 effective effective JJ cord-015021-pol2qm74 599 17 rate rate NN cord-015021-pol2qm74 599 18 was be VBD cord-015021-pol2qm74 599 19 87,5 87,5 CD cord-015021-pol2qm74 599 20 % % NN cord-015021-pol2qm74 599 21 , , , cord-015021-pol2qm74 599 22 in in IN cord-015021-pol2qm74 599 23 the the DT cord-015021-pol2qm74 599 24 contral contral JJ cord-015021-pol2qm74 599 25 group group NN cord-015021-pol2qm74 599 26 ( ( -LRB- cord-015021-pol2qm74 599 27 Combined combine VBN cord-015021-pol2qm74 599 28 administration administration NN cord-015021-pol2qm74 599 29 of of IN cord-015021-pol2qm74 599 30 gentamycin gentamycin NNP cord-015021-pol2qm74 599 31 and and CC cord-015021-pol2qm74 599 32 dexamethasone dexamethasone NN cord-015021-pol2qm74 599 33 , , , cord-015021-pol2qm74 599 34 25 25 CD cord-015021-pol2qm74 599 35 cases case NNS cord-015021-pol2qm74 599 36 ) ) -RRB- cord-015021-pol2qm74 599 37 the the DT cord-015021-pol2qm74 599 38 total total JJ cord-015021-pol2qm74 599 39 effective effective JJ cord-015021-pol2qm74 599 40 rate rate NN cord-015021-pol2qm74 599 41 was be VBD cord-015021-pol2qm74 599 42 84 84 CD cord-015021-pol2qm74 599 43 % % NN cord-015021-pol2qm74 599 44 . . . cord-015021-pol2qm74 600 1 However however RB cord-015021-pol2qm74 600 2 the the DT cord-015021-pol2qm74 600 3 obviously obviously RB cord-015021-pol2qm74 600 4 effective effective JJ cord-015021-pol2qm74 600 5 rate rate NN cord-015021-pol2qm74 600 6 in in IN cord-015021-pol2qm74 600 7 SA SA NNP cord-015021-pol2qm74 600 8 group group NN cord-015021-pol2qm74 600 9 70 70 CD cord-015021-pol2qm74 600 10 % % NN cord-015021-pol2qm74 600 11 was be VBD cord-015021-pol2qm74 600 12 significantly significantly RB cord-015021-pol2qm74 600 13 higher high JJR cord-015021-pol2qm74 600 14 than than IN cord-015021-pol2qm74 600 15 in in IN cord-015021-pol2qm74 600 16 contral contral JJ cord-015021-pol2qm74 600 17 group group NN cord-015021-pol2qm74 600 18 44 44 CD cord-015021-pol2qm74 600 19 % % NN cord-015021-pol2qm74 600 20 ( ( -LRB- cord-015021-pol2qm74 600 21 P p NN cord-015021-pol2qm74 600 22 < < XX cord-015021-pol2qm74 600 23 O.OS O.OS NNP cord-015021-pol2qm74 600 24 ) ) -RRB- cord-015021-pol2qm74 600 25 . . . cord-015021-pol2qm74 601 1 SA SA NNP cord-015021-pol2qm74 601 2 group group NN cord-015021-pol2qm74 601 3 appeared appear VBD cord-015021-pol2qm74 601 4 to to TO cord-015021-pol2qm74 601 5 be be VB cord-015021-pol2qm74 601 6 more more RBR cord-015021-pol2qm74 601 7 obvious obvious JJ cord-015021-pol2qm74 601 8 than than IN cord-015021-pol2qm74 601 9 the the DT cord-015021-pol2qm74 601 10 contral contral NNP cord-015021-pol2qm74 601 11 group group NN cord-015021-pol2qm74 601 12 in in IN cord-015021-pol2qm74 601 13 raising raise VBG cord-015021-pol2qm74 601 14 arterial arterial JJ cord-015021-pol2qm74 601 15 pressure pressure NN cord-015021-pol2qm74 601 16 , , , cord-015021-pol2qm74 601 17 recovering recover VBG cord-015021-pol2qm74 601 18 consciousness consciousness NN cord-015021-pol2qm74 601 19 and and CC cord-015021-pol2qm74 601 20 pulse pulse NN cord-015021-pol2qm74 601 21 , , , cord-015021-pol2qm74 601 22 improving improve VBG cord-015021-pol2qm74 601 23 cold cold JJ cord-015021-pol2qm74 601 24 lilmbs lilmb NNS cord-015021-pol2qm74 601 25 and and CC cord-015021-pol2qm74 601 26 reducing reduce VBG cord-015021-pol2qm74 601 27 fever fever NN cord-015021-pol2qm74 601 28 ( ( -LRB- cord-015021-pol2qm74 601 29 P p NN cord-015021-pol2qm74 601 30 < < XX cord-015021-pol2qm74 601 31 O.O5 O.O5 NNP cord-015021-pol2qm74 601 32 ) ) -RRB- cord-015021-pol2qm74 601 33 . . . cord-015021-pol2qm74 602 1 It -PRON- PRP cord-015021-pol2qm74 602 2 was be VBD cord-015021-pol2qm74 602 3 found find VBN cord-015021-pol2qm74 602 4 that that IN cord-015021-pol2qm74 602 5 SA SA NNP cord-015021-pol2qm74 602 6 could could MD cord-015021-pol2qm74 602 7 inhibit inhibit VB cord-015021-pol2qm74 602 8 the the DT cord-015021-pol2qm74 602 9 pathogeneses pathogenese NNS cord-015021-pol2qm74 602 10 changes change NNS cord-015021-pol2qm74 602 11 of of IN cord-015021-pol2qm74 602 12 septic septic JJ cord-015021-pol2qm74 602 13 shock shock NN cord-015021-pol2qm74 602 14 such such JJ cord-015021-pol2qm74 602 15 as as IN cord-015021-pol2qm74 602 16 the the DT cord-015021-pol2qm74 602 17 decreases decrease NNS cord-015021-pol2qm74 602 18 of of IN cord-015021-pol2qm74 602 19 superotide superotide NNP cord-015021-pol2qm74 602 20 dismutase dismutase NN cord-015021-pol2qm74 602 21 ( ( -LRB- cord-015021-pol2qm74 602 22 SOD SOD NNP cord-015021-pol2qm74 602 23 ) ) -RRB- cord-015021-pol2qm74 602 24 and and CC cord-015021-pol2qm74 602 25 glutathione glutathione NN cord-015021-pol2qm74 602 26 peroxidase peroxidase NN cord-015021-pol2qm74 602 27 ( ( -LRB- cord-015021-pol2qm74 602 28 GSH GSH NNP cord-015021-pol2qm74 602 29 - - HYPH cord-015021-pol2qm74 602 30 PX PX NNP cord-015021-pol2qm74 602 31 ) ) -RRB- cord-015021-pol2qm74 602 32 in in IN cord-015021-pol2qm74 602 33 erythrocytes erythrocyte NNS cord-015021-pol2qm74 602 34 and and CC cord-015021-pol2qm74 602 35 the the DT cord-015021-pol2qm74 602 36 increases increase NNS cord-015021-pol2qm74 602 37 of of IN cord-015021-pol2qm74 602 38 plasma plasma NN cord-015021-pol2qm74 602 39 free free JJ cord-015021-pol2qm74 602 40 hemoglobin hemoglobin NN cord-015021-pol2qm74 602 41 ( ( -LRB- cord-015021-pol2qm74 602 42 PHb PHb NNS cord-015021-pol2qm74 602 43 ) ) -RRB- cord-015021-pol2qm74 602 44 , , , cord-015021-pol2qm74 602 45 plasma plasma NNP cord-015021-pol2qm74 602 46 malondialdehyde malondialdehyde NNP cord-015021-pol2qm74 602 47 ( ( -LRB- cord-015021-pol2qm74 602 48 MDA MDA NNP cord-015021-pol2qm74 602 49 ) ) -RRB- cord-015021-pol2qm74 602 50 and and CC cord-015021-pol2qm74 602 51 13-glucuronidase 13-glucuronidase CD cord-015021-pol2qm74 602 52 ( ( -LRB- cord-015021-pol2qm74 602 53 13-GC 13-gc CD cord-015021-pol2qm74 602 54 ) ) -RRB- cord-015021-pol2qm74 602 55 occured occur VBD cord-015021-pol2qm74 602 56 in in IN cord-015021-pol2qm74 602 57 septic septic JJ cord-015021-pol2qm74 602 58 shock shock NN cord-015021-pol2qm74 602 59 . . . cord-015021-pol2qm74 603 1 SA SA NNP cord-015021-pol2qm74 603 2 had have VBD cord-015021-pol2qm74 603 3 stronger strong JJR cord-015021-pol2qm74 603 4 effect effect NN cord-015021-pol2qm74 603 5 than than IN cord-015021-pol2qm74 603 6 GD GD NNP cord-015021-pol2qm74 603 7 in in IN cord-015021-pol2qm74 603 8 inhibiting inhibit VBG cord-015021-pol2qm74 603 9 the the DT cord-015021-pol2qm74 603 10 changes change NNS cord-015021-pol2qm74 603 11 mentioned mention VBN cord-015021-pol2qm74 603 12 above above RB cord-015021-pol2qm74 603 13 . . . cord-015021-pol2qm74 604 1 Hence hence RB cord-015021-pol2qm74 604 2 , , , cord-015021-pol2qm74 604 3 these these DT cord-015021-pol2qm74 604 4 results result NNS cord-015021-pol2qm74 604 5 suggest suggest VBP cord-015021-pol2qm74 604 6 that that IN cord-015021-pol2qm74 604 7 SA SA NNP cord-015021-pol2qm74 604 8 has have VBZ cord-015021-pol2qm74 604 9 beneficial beneficial JJ cord-015021-pol2qm74 604 10 effect effect NN cord-015021-pol2qm74 604 11 in in IN cord-015021-pol2qm74 604 12 the the DT cord-015021-pol2qm74 604 13 treatment treatment NN cord-015021-pol2qm74 604 14 of of IN cord-015021-pol2qm74 604 15 septic septic JJ cord-015021-pol2qm74 604 16 shock shock NN cord-015021-pol2qm74 604 17 . . . cord-015021-pol2qm74 605 1 SA SA NNP cord-015021-pol2qm74 605 2 could could MD cord-015021-pol2qm74 605 3 diminish diminish VB cord-015021-pol2qm74 605 4 the the DT cord-015021-pol2qm74 605 5 decrease decrease NN cord-015021-pol2qm74 605 6 of of IN cord-015021-pol2qm74 605 7 the the DT cord-015021-pol2qm74 605 8 antioxdase antioxdase NNP cord-015021-pol2qm74 605 9 activities activity NNS cord-015021-pol2qm74 605 10 and and CC cord-015021-pol2qm74 605 11 inhibit inhibit VB cord-015021-pol2qm74 605 12 lipid lipid NN cord-015021-pol2qm74 605 13 peroxidization peroxidization NN cord-015021-pol2qm74 605 14 and and CC cord-015021-pol2qm74 605 15 stabilize stabilize VB cord-015021-pol2qm74 605 16 cellmembrance cellmembrance NN cord-015021-pol2qm74 605 17 . . . cord-015021-pol2qm74 606 1 This this DT cord-015021-pol2qm74 606 2 may may MD cord-015021-pol2qm74 606 3 be be VB cord-015021-pol2qm74 606 4 one one CD cord-015021-pol2qm74 606 5 of of IN cord-015021-pol2qm74 606 6 the the DT cord-015021-pol2qm74 606 7 principal principal JJ cord-015021-pol2qm74 606 8 mechanisms mechanism NNS cord-015021-pol2qm74 606 9 of of IN cord-015021-pol2qm74 606 10 the the DT cord-015021-pol2qm74 606 11 beneficial beneficial JJ cord-015021-pol2qm74 606 12 effect effect NN cord-015021-pol2qm74 606 13 of of IN cord-015021-pol2qm74 606 14 SA SA NNP cord-015021-pol2qm74 606 15 in in IN cord-015021-pol2qm74 606 16 the the DT cord-015021-pol2qm74 606 17 treatment treatment NN cord-015021-pol2qm74 606 18 of of IN cord-015021-pol2qm74 606 19 septic septic JJ cord-015021-pol2qm74 606 20 shock shock NN cord-015021-pol2qm74 606 21 . . . cord-015021-pol2qm74 607 1 Donna Donna NNP cord-015021-pol2qm74 607 2 L. L. NNP cord-015021-pol2qm74 607 3 Lehman Lehman NNP cord-015021-pol2qm74 607 4 , , , cord-015021-pol2qm74 607 5 Heather Heather NNP cord-015021-pol2qm74 607 6 A. A. NNP cord-015021-pol2qm74 607 7 Childers Childers NNP cord-015021-pol2qm74 607 8 , , , cord-015021-pol2qm74 607 9 Irshad Irshad NNP cord-015021-pol2qm74 607 10 H. H. NNP cord-015021-pol2qm74 607 11 Chaudry Chaudry NNP cord-015021-pol2qm74 607 12 and and CC cord-015021-pol2qm74 607 13 Alfred Alfred NNP cord-015021-pol2qm74 607 14 Ayala Ayala NNP cord-015021-pol2qm74 607 15 . . . cord-015021-pol2qm74 608 1 The the DT cord-015021-pol2qm74 608 2 thymus thymus NN cord-015021-pol2qm74 608 3 is be VBZ cord-015021-pol2qm74 608 4 thought think VBN cord-015021-pol2qm74 608 5 to to TO cord-015021-pol2qm74 608 6 be be VB cord-015021-pol2qm74 608 7 a a DT cord-015021-pol2qm74 608 8 privileged privileged JJ cord-015021-pol2qm74 608 9 sight sight NN cord-015021-pol2qm74 608 10 for for IN cord-015021-pol2qm74 608 11 Tcell Tcell NNP cord-015021-pol2qm74 608 12 generation generation NN cord-015021-pol2qm74 608 13 . . . cord-015021-pol2qm74 609 1 Here here RB cord-015021-pol2qm74 609 2 the the DT cord-015021-pol2qm74 609 3 T t NN cord-015021-pol2qm74 609 4 - - HYPH cord-015021-pol2qm74 609 5 lymphocytes lymphocyte NNS cord-015021-pol2qm74 609 6 are be VBP cord-015021-pol2qm74 609 7 either either RB cord-015021-pol2qm74 609 8 selected select VBN cord-015021-pol2qm74 609 9 for for IN cord-015021-pol2qm74 609 10 their -PRON- PRP$ cord-015021-pol2qm74 609 11 potential potential NN cord-015021-pol2qm74 609 12 to to TO cord-015021-pol2qm74 609 13 recognize recognize VB cord-015021-pol2qm74 609 14 and and CC cord-015021-pol2qm74 609 15 react react VB cord-015021-pol2qm74 609 16 competently competently RB cord-015021-pol2qm74 609 17 to to IN cord-015021-pol2qm74 609 18 foreign foreign JJ cord-015021-pol2qm74 609 19 antigens antigen NNS cord-015021-pol2qm74 609 20 or or CC cord-015021-pol2qm74 609 21 de de JJ cord-015021-pol2qm74 609 22 - - VBN cord-015021-pol2qm74 609 23 selected select VBN cord-015021-pol2qm74 609 24 , , , cord-015021-pol2qm74 609 25 due due IN cord-015021-pol2qm74 609 26 to to IN cord-015021-pol2qm74 609 27 their -PRON- PRP$ cord-015021-pol2qm74 609 28 potential potential NN cord-015021-pol2qm74 609 29 to to TO cord-015021-pol2qm74 609 30 react react VB cord-015021-pol2qm74 609 31 to to IN cord-015021-pol2qm74 609 32 auto auto NN cord-015021-pol2qm74 609 33 - - HYPH cord-015021-pol2qm74 609 34 antigens antigen NNS cord-015021-pol2qm74 609 35 , , , cord-015021-pol2qm74 609 36 de de NN cord-015021-pol2qm74 609 37 - - VBN cord-015021-pol2qm74 609 38 selected select VBN cord-015021-pol2qm74 609 39 . . . cord-015021-pol2qm74 610 1 Tcells Tcells NNP cord-015021-pol2qm74 610 2 with with IN cord-015021-pol2qm74 610 3 this this DT cord-015021-pol2qm74 610 4 latter latter JJ cord-015021-pol2qm74 610 5 capacity capacity NN cord-015021-pol2qm74 610 6 are be VBP cord-015021-pol2qm74 610 7 thought think VBN cord-015021-pol2qm74 610 8 to to TO cord-015021-pol2qm74 610 9 be be VB cord-015021-pol2qm74 610 10 deselected deselecte VBN cord-015021-pol2qm74 610 11 through through IN cord-015021-pol2qm74 610 12 a a DT cord-015021-pol2qm74 610 13 process process NN cord-015021-pol2qm74 610 14 referred refer VBN cord-015021-pol2qm74 610 15 to to IN cord-015021-pol2qm74 610 16 as as IN cord-015021-pol2qm74 610 17 programmed program VBN cord-015021-pol2qm74 610 18 cell cell NN cord-015021-pol2qm74 610 19 death death NN cord-015021-pol2qm74 610 20 or or CC cord-015021-pol2qm74 610 21 apoptosis apoptosis NN cord-015021-pol2qm74 610 22 . . . cord-015021-pol2qm74 611 1 While while IN cord-015021-pol2qm74 611 2 it -PRON- PRP cord-015021-pol2qm74 611 3 is be VBZ cord-015021-pol2qm74 611 4 known know VBN cord-015021-pol2qm74 611 5 that that IN cord-015021-pol2qm74 611 6 thymic thymic JJ cord-015021-pol2qm74 611 7 apoptosis apoptosis NN cord-015021-pol2qm74 611 8 is be VBZ cord-015021-pol2qm74 611 9 elevated elevate VBN cord-015021-pol2qm74 611 10 by by IN cord-015021-pol2qm74 611 11 a a DT cord-015021-pol2qm74 611 12 variety variety NN cord-015021-pol2qm74 611 13 of of IN cord-015021-pol2qm74 611 14 stressers stresser NNS cord-015021-pol2qm74 611 15 associated associate VBN cord-015021-pol2qm74 611 16 with with IN cord-015021-pol2qm74 611 17 infection infection NN cord-015021-pol2qm74 611 18 and and CC cord-015021-pol2qm74 611 19 inflammation inflammation NN cord-015021-pol2qm74 611 20 , , , cord-015021-pol2qm74 611 21 little little JJ cord-015021-pol2qm74 611 22 or or CC cord-015021-pol2qm74 611 23 no no DT cord-015021-pol2qm74 611 24 information information NN cord-015021-pol2qm74 611 25 is be VBZ cord-015021-pol2qm74 611 26 available available JJ cord-015021-pol2qm74 611 27 concerning concern VBG cord-015021-pol2qm74 611 28 its -PRON- PRP$ cord-015021-pol2qm74 611 29 presence presence NN cord-015021-pol2qm74 611 30 in in IN cord-015021-pol2qm74 611 31 polymicrobial polymicrobial JJ cord-015021-pol2qm74 611 32 sepsis sepsis NN cord-015021-pol2qm74 611 33 . . . cord-015021-pol2qm74 612 1 It -PRON- PRP cord-015021-pol2qm74 612 2 was be VBD cord-015021-pol2qm74 612 3 , , , cord-015021-pol2qm74 612 4 therefore therefore RB cord-015021-pol2qm74 612 5 , , , cord-015021-pol2qm74 612 6 the the DT cord-015021-pol2qm74 612 7 aim aim NN cord-015021-pol2qm74 612 8 of of IN cord-015021-pol2qm74 612 9 this this DT cord-015021-pol2qm74 612 10 study study NN cord-015021-pol2qm74 612 11 to to TO cord-015021-pol2qm74 612 12 determine determine VB cord-015021-pol2qm74 612 13 whether whether IN cord-015021-pol2qm74 612 14 thymocytes thymocyte NNS cord-015021-pol2qm74 612 15 exhibit exhibit NN cord-015021-pol2qm74 612 16 increased increase VBN cord-015021-pol2qm74 612 17 apoptosis apoptosis NN cord-015021-pol2qm74 612 18 during during IN cord-015021-pol2qm74 612 19 sepsis sepsis NN cord-015021-pol2qm74 612 20 . . . cord-015021-pol2qm74 613 1 To to TO cord-015021-pol2qm74 613 2 assess assess VB cord-015021-pol2qm74 613 3 this this DT cord-015021-pol2qm74 613 4 , , , cord-015021-pol2qm74 613 5 thymocytes thymocyte NNS cord-015021-pol2qm74 613 6 were be VBD cord-015021-pol2qm74 613 7 harvested harvest VBN cord-015021-pol2qm74 613 8 from from IN cord-015021-pol2qm74 613 9 C3H c3h JJ cord-015021-pol2qm74 613 10 / / SYM cord-015021-pol2qm74 613 11 HeN hen JJ cord-015021-pol2qm74 613 12 mice mouse NNS cord-015021-pol2qm74 613 13 at at IN cord-015021-pol2qm74 613 14 i i PRP cord-015021-pol2qm74 613 15 and and CC cord-015021-pol2qm74 613 16 24 24 CD cord-015021-pol2qm74 613 17 h h NN cord-015021-pol2qm74 613 18 following follow VBG cord-015021-pol2qm74 613 19 cecal cecal JJ cord-015021-pol2qm74 613 20 ligation ligation NN cord-015021-pol2qm74 613 21 and and CC cord-015021-pol2qm74 613 22 puncture puncture NN cord-015021-pol2qm74 613 23 ( ( -LRB- cord-015021-pol2qm74 613 24 CLP clp NN cord-015021-pol2qm74 613 25 ; ; : cord-015021-pol2qm74 613 26 to to TO cord-015021-pol2qm74 613 27 induce induce VB cord-015021-pol2qm74 613 28 sepsis sepsis NN cord-015021-pol2qm74 613 29 ) ) -RRB- cord-015021-pol2qm74 613 30 or or CC cord-015021-pol2qm74 613 31 Sham Sham NNP cord-015021-pol2qm74 613 32 - - HYPH cord-015021-pol2qm74 613 33 CLP CLP NNP cord-015021-pol2qm74 613 34 ( ( -LRB- cord-015021-pol2qm74 613 35 Sham Sham NNP cord-015021-pol2qm74 613 36 ) ) -RRB- cord-015021-pol2qm74 613 37 . . . cord-015021-pol2qm74 614 1 Thymic Thymic NNP cord-015021-pol2qm74 614 2 yields yield NNS cord-015021-pol2qm74 614 3 were be VBD cord-015021-pol2qm74 614 4 assessed assess VBN cord-015021-pol2qm74 614 5 and and CC cord-015021-pol2qm74 614 6 the the DT cord-015021-pol2qm74 614 7 extent extent NN cord-015021-pol2qm74 614 8 of of IN cord-015021-pol2qm74 614 9 apetosis apetosis NN cord-015021-pol2qm74 614 10 determined determine VBN cord-015021-pol2qm74 614 11 by by IN cord-015021-pol2qm74 614 12 staining stain VBG cord-015021-pol2qm74 614 13 the the DT cord-015021-pol2qm74 614 14 cells cell NNS cord-015021-pol2qm74 614 15 with with IN cord-015021-pol2qm74 614 16 propidium propidium NN cord-015021-pol2qm74 614 17 iodide iodide NN cord-015021-pol2qm74 614 18 ( ( -LRB- cord-015021-pol2qm74 614 19 a a DT cord-015021-pol2qm74 614 20 DNA dna NN cord-015021-pol2qm74 614 21 intercalating intercalating NN cord-015021-pol2qm74 614 22 dye dye NN cord-015021-pol2qm74 614 23 ) ) -RRB- cord-015021-pol2qm74 614 24 for for IN cord-015021-pol2qm74 614 25 FACS FACS NNP cord-015021-pol2qm74 614 26 analysis analysis NN cord-015021-pol2qm74 614 27 or or CC cord-015021-pol2qm74 614 28 by by IN cord-015021-pol2qm74 614 29 examining examine VBG cord-015021-pol2qm74 614 30 the the DT cord-015021-pol2qm74 614 31 extracted extract VBN cord-015021-pol2qm74 614 32 DNA dna NN cord-015021-pol2qm74 614 33 electrophoretically electrophoretically RB cord-015021-pol2qm74 614 34 for for IN cord-015021-pol2qm74 614 35 the the DT cord-015021-pol2qm74 614 36 endogenous endogenous JJ cord-015021-pol2qm74 614 37 endonuclease endonuclease NN cord-015021-pol2qm74 614 38 activity activity NN cord-015021-pol2qm74 615 1 The the DT cord-015021-pol2qm74 615 2 results result NNS cord-015021-pol2qm74 615 3 ( ( -LRB- cord-015021-pol2qm74 615 4 n=6 n=6 NNP cord-015021-pol2qm74 615 5 / / SYM cord-015021-pol2qm74 615 6 grp grp NNP cord-015021-pol2qm74 615 7 ) ) -RRB- cord-015021-pol2qm74 615 8 indicate indicate VBP cord-015021-pol2qm74 615 9 that that IN cord-015021-pol2qm74 615 10 at at IN cord-015021-pol2qm74 615 11 I -PRON- PRP cord-015021-pol2qm74 616 1 h h NNP cord-015021-pol2qm74 616 2 post post NNP cord-015021-pol2qm74 616 3 - - NNP cord-015021-pol2qm74 616 4 CLP CLP NNP cord-015021-pol2qm74 616 5 there there EX cord-015021-pol2qm74 616 6 was be VBD cord-015021-pol2qm74 616 7 no no DT cord-015021-pol2qm74 616 8 marked marked JJ cord-015021-pol2qm74 616 9 changes change NNS cord-015021-pol2qm74 616 10 in in IN cord-015021-pol2qm74 616 11 any any DT cord-015021-pol2qm74 616 12 of of IN cord-015021-pol2qm74 616 13 these these DT cord-015021-pol2qm74 616 14 parameters parameter NNS cord-015021-pol2qm74 616 15 . . . cord-015021-pol2qm74 617 1 However however RB cord-015021-pol2qm74 617 2 , , , cord-015021-pol2qm74 617 3 at at IN cord-015021-pol2qm74 617 4 24 24 CD cord-015021-pol2qm74 617 5 h h NN cord-015021-pol2qm74 617 6 the the DT cord-015021-pol2qm74 617 7 thymic thymic JJ cord-015021-pol2qm74 617 8 cell cell NN cord-015021-pol2qm74 617 9 yield yield NN cord-015021-pol2qm74 617 10 from from IN cord-015021-pol2qm74 617 11 CLP CLP NNP cord-015021-pol2qm74 617 12 mice mouse NNS cord-015021-pol2qm74 617 13 was be VBD cord-015021-pol2qm74 617 14 significantly significantly RB cord-015021-pol2qm74 617 15 decreased decrease VBN cord-015021-pol2qm74 617 16 ( ( -LRB- cord-015021-pol2qm74 617 17 Sham:3.6!0.2 Sham:3.6!0.2 NNP cord-015021-pol2qm74 617 18 x x NNP cord-015021-pol2qm74 617 19 l06 l06 CD cord-015021-pol2qm74 617 20 vs vs IN cord-015021-pol2qm74 617 21 CLP:0.3i0.1 CLP:0.3i0.1 NNP cord-015021-pol2qm74 617 22 x x SYM cord-015021-pol2qm74 617 23 106 106 CD cord-015021-pol2qm74 617 24 * * NFP cord-015021-pol2qm74 617 25 cells cell NNS cord-015021-pol2qm74 617 26 ; ; : cord-015021-pol2qm74 617 27 * * NFP cord-015021-pol2qm74 617 28 , , , cord-015021-pol2qm74 617 29 p<0.05 p<0.05 CD cord-015021-pol2qm74 617 30 ) ) -RRB- cord-015021-pol2qm74 617 31 , , , cord-015021-pol2qm74 617 32 the the DT cord-015021-pol2qm74 617 33 % % NN cord-015021-pol2qm74 617 34 of of IN cord-015021-pol2qm74 617 35 cells cell NNS cord-015021-pol2qm74 617 36 apoptotic apoptotic JJ cord-015021-pol2qm74 617 37 by by IN cord-015021-pol2qm74 617 38 FACS FACS NNP cord-015021-pol2qm74 617 39 analysis analysis NN cord-015021-pol2qm74 617 40 increased increase VBD cord-015021-pol2qm74 617 41 from from IN cord-015021-pol2qm74 617 42 1.7i0.1 1.7i0.1 CD cord-015021-pol2qm74 617 43 % % NN cord-015021-pol2qm74 617 44 in in IN cord-015021-pol2qm74 617 45 Sham Sham NNP cord-015021-pol2qm74 617 46 to to IN cord-015021-pol2qm74 617 47 8.7±3.2 8.7±3.2 NNP cord-015021-pol2qm74 617 48 % % NN cord-015021-pol2qm74 617 49 * * NFP cord-015021-pol2qm74 617 50 in in IN cord-015021-pol2qm74 617 51 CLP CLP NNP cord-015021-pol2qm74 617 52 , , , cord-015021-pol2qm74 617 53 and and CC cord-015021-pol2qm74 617 54 the the DT cord-015021-pol2qm74 617 55 septic septic JJ cord-015021-pol2qm74 617 56 mouse mouse NN cord-015021-pol2qm74 617 57 genomic genomic JJ cord-015021-pol2qm74 617 58 DNA DNA NNP cord-015021-pol2qm74 617 59 exhibited exhibit VBD cord-015021-pol2qm74 617 60 DNA dna NN cord-015021-pol2qm74 617 61 degradation degradation NN cord-015021-pol2qm74 617 62 These these DT cord-015021-pol2qm74 617 63 results result NNS cord-015021-pol2qm74 617 64 indicate indicate VBP cord-015021-pol2qm74 617 65 that that IN cord-015021-pol2qm74 617 66 CLP CLP NNP cord-015021-pol2qm74 617 67 , , , cord-015021-pol2qm74 617 68 but but CC cord-015021-pol2qm74 617 69 not not RB cord-015021-pol2qm74 617 70 simple simple JJ cord-015021-pol2qm74 617 71 laparotomy laparotomy NN cord-015021-pol2qm74 617 72 , , , cord-015021-pol2qm74 617 73 induces induce VBZ cord-015021-pol2qm74 617 74 marked mark VBD cord-015021-pol2qm74 617 75 thymic thymic JJ cord-015021-pol2qm74 617 76 apetosis apetosis NN cord-015021-pol2qm74 617 77 , , , cord-015021-pol2qm74 617 78 which which WDT cord-015021-pol2qm74 617 79 may may MD cord-015021-pol2qm74 617 80 contribute contribute VB cord-015021-pol2qm74 617 81 to to IN cord-015021-pol2qm74 617 82 the the DT cord-015021-pol2qm74 617 83 lymphocytic lymphocytic JJ cord-015021-pol2qm74 617 84 immune immune JJ cord-015021-pol2qm74 617 85 deficiency deficiency NN cord-015021-pol2qm74 617 86 seen see VBN cord-015021-pol2qm74 617 87 in in IN cord-015021-pol2qm74 617 88 these these DT cord-015021-pol2qm74 617 89 mice mouse NNS cord-015021-pol2qm74 617 90 _SP cord-015021-pol2qm74 618 1 The the DT cord-015021-pol2qm74 618 2 purpose purpose NN cord-015021-pol2qm74 618 3 of of IN cord-015021-pol2qm74 618 4 this this DT cord-015021-pol2qm74 618 5 retrospective retrospective JJ cord-015021-pol2qm74 618 6 study study NN cord-015021-pol2qm74 618 7 was be VBD cord-015021-pol2qm74 618 8 to to TO cord-015021-pol2qm74 618 9 evaluate evaluate VB cord-015021-pol2qm74 618 10 effectiveness effectiveness NN cord-015021-pol2qm74 618 11 of of IN cord-015021-pol2qm74 618 12 irrigation irrigation NN cord-015021-pol2qm74 618 13 to to TO cord-015021-pol2qm74 618 14 treat treat VB cord-015021-pol2qm74 618 15 septic septic JJ cord-015021-pol2qm74 618 16 knee knee NN cord-015021-pol2qm74 618 17 joints joint NNS cord-015021-pol2qm74 618 18 from from IN cord-015021-pol2qm74 618 19 longterm longterm JJ cord-015021-pol2qm74 618 20 results result NNS cord-015021-pol2qm74 618 21 . . . cord-015021-pol2qm74 619 1 From from IN cord-015021-pol2qm74 619 2 1982 1982 CD cord-015021-pol2qm74 619 3 to to IN cord-015021-pol2qm74 619 4 1992 1992 CD cord-015021-pol2qm74 619 5 31 31 CD cord-015021-pol2qm74 619 6 patients patient NNS cord-015021-pol2qm74 619 7 with with IN cord-015021-pol2qm74 619 8 septic septic JJ cord-015021-pol2qm74 619 9 knee knee NN cord-015021-pol2qm74 619 10 joints joint NNS cord-015021-pol2qm74 619 11 have have VBP cord-015021-pol2qm74 619 12 been be VBN cord-015021-pol2qm74 619 13 treated treat VBN cord-015021-pol2qm74 619 14 . . . cord-015021-pol2qm74 620 1 Treatment treatment NN cord-015021-pol2qm74 620 2 in in IN cord-015021-pol2qm74 620 3 acute acute JJ cord-015021-pol2qm74 620 4 cases case NNS cord-015021-pol2qm74 620 5 started start VBD cord-015021-pol2qm74 620 6 with with IN cord-015021-pol2qm74 620 7 asp#at[on asp#at[on NNP cord-015021-pol2qm74 620 8 of of IN cord-015021-pol2qm74 620 9 the the DT cord-015021-pol2qm74 620 10 effusion effusion NN cord-015021-pol2qm74 620 11 to to TO cord-015021-pol2qm74 620 12 evaluate evaluate VB cord-015021-pol2qm74 620 13 for for IN cord-015021-pol2qm74 620 14 cultures culture NNS cord-015021-pol2qm74 620 15 . . . cord-015021-pol2qm74 621 1 Without without IN cord-015021-pol2qm74 621 2 awaiting await VBG cord-015021-pol2qm74 621 3 the the DT cord-015021-pol2qm74 621 4 result result NN cord-015021-pol2qm74 621 5 treatment treatment NN cord-015021-pol2qm74 621 6 was be VBD cord-015021-pol2qm74 621 7 continued continue VBN cord-015021-pol2qm74 621 8 with with IN cord-015021-pol2qm74 621 9 immediate immediate JJ cord-015021-pol2qm74 621 10 joint joint JJ cord-015021-pol2qm74 621 11 irrigation irrigation NN cord-015021-pol2qm74 621 12 under under IN cord-015021-pol2qm74 621 13 arthroscopic arthroscopic JJ cord-015021-pol2qm74 621 14 control control NN cord-015021-pol2qm74 621 15 . . . cord-015021-pol2qm74 622 1 Three three CD cord-015021-pol2qm74 622 2 redon redon NNP cord-015021-pol2qm74 622 3 tubes tube NNS cord-015021-pol2qm74 622 4 ( ( -LRB- cord-015021-pol2qm74 622 5 CH CH NNP cord-015021-pol2qm74 622 6 16 16 CD cord-015021-pol2qm74 622 7 ) ) -RRB- cord-015021-pol2qm74 622 8 were be VBD cord-015021-pol2qm74 622 9 introduced introduce VBN cord-015021-pol2qm74 622 10 for for IN cord-015021-pol2qm74 622 11 continuous continuous JJ cord-015021-pol2qm74 622 12 irrigation irrigation NN cord-015021-pol2qm74 622 13 and and CC cord-015021-pol2qm74 622 14 for for IN cord-015021-pol2qm74 622 15 intermittent intermittent JJ cord-015021-pol2qm74 622 16 distention distention NN cord-015021-pol2qm74 622 17 of of IN cord-015021-pol2qm74 622 18 the the DT cord-015021-pol2qm74 622 19 joint joint JJ cord-015021-pol2qm74 622 20 cavity cavity NN cord-015021-pol2qm74 622 21 . . . cord-015021-pol2qm74 623 1 In in IN cord-015021-pol2qm74 623 2 case case NN cord-015021-pol2qm74 623 3 of of IN cord-015021-pol2qm74 623 4 chronic chronic JJ cord-015021-pol2qm74 623 5 joint joint JJ cord-015021-pol2qm74 623 6 infection infection NN cord-015021-pol2qm74 623 7 additionally additionally RB cord-015021-pol2qm74 623 8 all all DT cord-015021-pol2qm74 623 9 foreign foreign JJ cord-015021-pol2qm74 623 10 and and CC cord-015021-pol2qm74 623 11 synthetic synthetic JJ cord-015021-pol2qm74 623 12 material material NN cord-015021-pol2qm74 623 13 was be VBD cord-015021-pol2qm74 623 14 removed remove VBN cord-015021-pol2qm74 623 15 . . . cord-015021-pol2qm74 624 1 Systemic systemic JJ cord-015021-pol2qm74 624 2 antibiotics antibiotic NNS cord-015021-pol2qm74 624 3 were be VBD cord-015021-pol2qm74 624 4 given give VBN cord-015021-pol2qm74 624 5 . . . cord-015021-pol2qm74 625 1 Patients patient NNS cord-015021-pol2qm74 625 2 could could MD cord-015021-pol2qm74 625 3 be be VB cord-015021-pol2qm74 625 4 re re VBN cord-015021-pol2qm74 625 5 -examined -examine VBN cord-015021-pol2qm74 625 6 with with IN cord-015021-pol2qm74 625 7 a a DT cord-015021-pol2qm74 625 8 mean mean JJ cord-015021-pol2qm74 625 9 follow follow NN cord-015021-pol2qm74 625 10 - - HYPH cord-015021-pol2qm74 625 11 up up NN cord-015021-pol2qm74 625 12 of of IN cord-015021-pol2qm74 625 13 6 6 CD cord-015021-pol2qm74 625 14 years year NNS cord-015021-pol2qm74 625 15 . . . cord-015021-pol2qm74 626 1 Re re NN cord-015021-pol2qm74 626 2 - - NN cord-015021-pol2qm74 626 3 examination examination NN cord-015021-pol2qm74 626 4 showed show VBD cord-015021-pol2qm74 626 5 that that IN cord-015021-pol2qm74 626 6 immediate immediate JJ cord-015021-pol2qm74 626 7 arthroscopic arthroscopic JJ cord-015021-pol2qm74 626 8 lavage lavage NN cord-015021-pol2qm74 626 9 started start VBD cord-015021-pol2qm74 626 10 at at IN cord-015021-pol2qm74 626 11 the the DT cord-015021-pol2qm74 626 12 onset onset NN cord-015021-pol2qm74 626 13 of of IN cord-015021-pol2qm74 626 14 septic septic NN cord-015021-pol2qm74 626 15 sings sing NNS cord-015021-pol2qm74 626 16 had have VBD cord-015021-pol2qm74 626 17 best good JJS cord-015021-pol2qm74 626 18 results result NNS cord-015021-pol2qm74 626 19 ( ( -LRB- cord-015021-pol2qm74 626 20 less less JJR cord-015021-pol2qm74 626 21 signs sign NNS cord-015021-pol2qm74 626 22 of of IN cord-015021-pol2qm74 626 23 osteoarthr[tis osteoarthr[tis NNP cord-015021-pol2qm74 626 24 , , , cord-015021-pol2qm74 626 25 less less RBR cord-015021-pol2qm74 626 26 synovitis synovitis JJ cord-015021-pol2qm74 626 27 , , , cord-015021-pol2qm74 626 28 less less JJR cord-015021-pol2qm74 626 29 pain pain NN cord-015021-pol2qm74 626 30 while while IN cord-015021-pol2qm74 626 31 loading load VBG cord-015021-pol2qm74 626 32 and and CC cord-015021-pol2qm74 626 33 less less JJR cord-015021-pol2qm74 626 34 range range NN cord-015021-pol2qm74 626 35 of of IN cord-015021-pol2qm74 626 36 motion motion NN cord-015021-pol2qm74 626 37 loss loss NN cord-015021-pol2qm74 626 38 ) ) -RRB- cord-015021-pol2qm74 626 39 . . . cord-015021-pol2qm74 627 1 21 21 CD cord-015021-pol2qm74 627 2 patients patient NNS cord-015021-pol2qm74 627 3 ( ( -LRB- cord-015021-pol2qm74 627 4 80 80 CD cord-015021-pol2qm74 627 5 % % NN cord-015021-pol2qm74 627 6 ) ) -RRB- cord-015021-pol2qm74 627 7 out out IN cord-015021-pol2qm74 627 8 of of IN cord-015021-pol2qm74 627 9 26 26 CD cord-015021-pol2qm74 627 10 patients patient NNS cord-015021-pol2qm74 627 11 with with IN cord-015021-pol2qm74 627 12 s s NN cord-015021-pol2qm74 628 1 tre_=.tsd tre_=.tsd NNP cord-015021-pol2qm74 628 2 acute acute JJ cord-015021-pol2qm74 628 3 se.~tic se.~tic JJ cord-015021-pol2qm74 628 4 knee knee NN cord-015021-pol2qm74 628 5 joint joint NN cord-015021-pol2qm74 628 6 had have VBD cord-015021-pol2qm74 628 7 excellent excellent JJ cord-015021-pol2qm74 628 8 functional functional JJ cord-015021-pol2qm74 628 9 recovery recovery NN cord-015021-pol2qm74 628 10 , , , cord-015021-pol2qm74 628 11 whereas whereas IN cord-015021-pol2qm74 628 12 all all DT cord-015021-pol2qm74 628 13 5 5 CD cord-015021-pol2qm74 628 14 patients patient NNS cord-015021-pol2qm74 628 15 with with IN cord-015021-pol2qm74 628 16 chronic chronic JJ cord-015021-pol2qm74 628 17 septic septic JJ cord-015021-pol2qm74 628 18 knee knee NN cord-015021-pol2qm74 628 19 joints joint NNS cord-015021-pol2qm74 628 20 showed show VBD cord-015021-pol2qm74 628 21 poor poor JJ cord-015021-pol2qm74 628 22 results result NNS cord-015021-pol2qm74 628 23 . . . cord-015021-pol2qm74 629 1 Additionally additionally RB cord-015021-pol2qm74 629 2 , , , cord-015021-pol2qm74 629 3 in in IN cord-015021-pol2qm74 629 4 3 3 CD cord-015021-pol2qm74 629 5 of of IN cord-015021-pol2qm74 629 6 these these DT cord-015021-pol2qm74 629 7 5 5 CD cord-015021-pol2qm74 629 8 patients patient NNS cord-015021-pol2qm74 629 9 with with IN cord-015021-pol2qm74 629 10 chronic chronic JJ cord-015021-pol2qm74 629 11 septic septic JJ cord-015021-pol2qm74 629 12 knee knee NN cord-015021-pol2qm74 629 13 joint joint NN cord-015021-pol2qm74 629 14 after after IN cord-015021-pol2qm74 629 15 irrigation irrigation NN cord-015021-pol2qm74 629 16 a a DT cord-015021-pol2qm74 629 17 further further JJ cord-015021-pol2qm74 629 18 procedure procedure NN cord-015021-pol2qm74 629 19 was be VBD cord-015021-pol2qm74 629 20 necessary necessary JJ cord-015021-pol2qm74 629 21 due due IN cord-015021-pol2qm74 629 22 to to IN cord-015021-pol2qm74 629 23 recurrent recurrent JJ cord-015021-pol2qm74 629 24 septic septic JJ cord-015021-pol2qm74 629 25 knee knee NN cord-015021-pol2qm74 629 26 joint joint NN cord-015021-pol2qm74 629 27 . . . cord-015021-pol2qm74 630 1 The the DT cord-015021-pol2qm74 630 2 concept concept NN cord-015021-pol2qm74 630 3 that that IN cord-015021-pol2qm74 630 4 bacteria bacteria NNS cord-015021-pol2qm74 630 5 can can MD cord-015021-pol2qm74 630 6 translocate translocate VB cord-015021-pol2qm74 630 7 across across IN cord-015021-pol2qm74 630 8 the the DT cord-015021-pol2qm74 630 9 intestinal intestinal JJ cord-015021-pol2qm74 630 10 mucosa mucosa NN cord-015021-pol2qm74 630 11 under under IN cord-015021-pol2qm74 630 12 a a DT cord-015021-pol2qm74 630 13 variety variety NN cord-015021-pol2qm74 630 14 of of IN cord-015021-pol2qm74 630 15 circumstances circumstance NNS cord-015021-pol2qm74 630 16 is be VBZ cord-015021-pol2qm74 630 17 well well RB cord-015021-pol2qm74 630 18 established establish VBN cord-015021-pol2qm74 630 19 . . . cord-015021-pol2qm74 631 1 However however RB cord-015021-pol2qm74 631 2 , , , cord-015021-pol2qm74 631 3 due due IN cord-015021-pol2qm74 631 4 to to IN cord-015021-pol2qm74 631 5 the the DT cord-015021-pol2qm74 631 6 inherent inherent JJ cord-015021-pol2qm74 631 7 limitations limitation NNS cord-015021-pol2qm74 631 8 of of IN cord-015021-pol2qm74 631 9 in in IN cord-015021-pol2qm74 631 10 vivo vivo NNP cord-015021-pol2qm74 631 11 studies study NNS cord-015021-pol2qm74 631 12 , , , cord-015021-pol2qm74 631 13 the the DT cord-015021-pol2qm74 631 14 cellular cellular JJ cord-015021-pol2qm74 631 15 mechanisms mechanism NNS cord-015021-pol2qm74 631 16 underlying underlie VBG cord-015021-pol2qm74 631 17 the the DT cord-015021-pol2qm74 631 18 process process NN cord-015021-pol2qm74 631 19 of of IN cord-015021-pol2qm74 631 20 bacterial bacterial JJ cord-015021-pol2qm74 631 21 translocation translocation NN cord-015021-pol2qm74 631 22 ( ( -LRB- cord-015021-pol2qm74 631 23 BT BT NNP cord-015021-pol2qm74 631 24 ) ) -RRB- cord-015021-pol2qm74 631 25 across across IN cord-015021-pol2qm74 631 26 the the DT cord-015021-pol2qm74 631 27 epithelial epithelial JJ cord-015021-pol2qm74 631 28 barrier barrier NN cord-015021-pol2qm74 631 29 are be VBP cord-015021-pol2qm74 631 30 poorly poorly RB cord-015021-pol2qm74 631 31 understood understand VBN cord-015021-pol2qm74 631 32 . . . cord-015021-pol2qm74 632 1 This this DT cord-015021-pol2qm74 632 2 is be VBZ cord-015021-pol2qm74 632 3 especially especially RB cord-015021-pol2qm74 632 4 true true JJ cord-015021-pol2qm74 632 5 in in IN cord-015021-pol2qm74 632 6 those those DT cord-015021-pol2qm74 632 7 circumstances circumstance NNS cord-015021-pol2qm74 632 8 in in IN cord-015021-pol2qm74 632 9 which which WDT cord-015021-pol2qm74 632 10 there there EX cord-015021-pol2qm74 632 11 is be VBZ cord-015021-pol2qm74 632 12 no no DT cord-015021-pol2qm74 632 13 merphologic merphologic JJ cord-015021-pol2qm74 632 14 evidence evidence NN cord-015021-pol2qm74 632 15 of of IN cord-015021-pol2qm74 632 16 mucosal mucosal JJ cord-015021-pol2qm74 632 17 injury injury NN cord-015021-pol2qm74 632 18 . . . cord-015021-pol2qm74 633 1 Consequently consequently RB cord-015021-pol2qm74 633 2 , , , cord-015021-pol2qm74 633 3 we -PRON- PRP cord-015021-pol2qm74 633 4 have have VBP cord-015021-pol2qm74 633 5 utilized utilize VBN cord-015021-pol2qm74 633 6 an an DT cord-015021-pol2qm74 633 7 in in IN cord-015021-pol2qm74 633 8 vitro vitro FW cord-015021-pol2qm74 633 9 cell cell NN cord-015021-pol2qm74 633 10 culture culture NN cord-015021-pol2qm74 633 11 model model NN cord-015021-pol2qm74 633 12 system system NN cord-015021-pol2qm74 633 13 to to TO cord-015021-pol2qm74 633 14 investigate investigate VB cord-015021-pol2qm74 633 15 the the DT cord-015021-pol2qm74 633 16 cellular cellular JJ cord-015021-pol2qm74 633 17 events event NNS cord-015021-pol2qm74 633 18 involved involve VBN cord-015021-pol2qm74 633 19 in in IN cord-015021-pol2qm74 633 20 the the DT cord-015021-pol2qm74 633 21 translocation translocation NN cord-015021-pol2qm74 633 22 process process NN cord-015021-pol2qm74 633 23 . . . cord-015021-pol2qm74 634 1 In in IN cord-015021-pol2qm74 634 2 this this DT cord-015021-pol2qm74 634 3 model model NN cord-015021-pol2qm74 634 4 system system NN cord-015021-pol2qm74 634 5 , , , cord-015021-pol2qm74 634 6 a a DT cord-015021-pol2qm74 634 7 polarized polarized JJ cord-015021-pol2qm74 634 8 monolayer monolayer NN cord-015021-pol2qm74 634 9 of of IN cord-015021-pol2qm74 634 10 intestinal intestinal JJ cord-015021-pol2qm74 634 11 cells cell NNS cord-015021-pol2qm74 634 12 ( ( -LRB- cord-015021-pol2qm74 634 13 Caco-2 caco-2 NN cord-015021-pol2qm74 634 14 cell cell NN cord-015021-pol2qm74 634 15 line line NN cord-015021-pol2qm74 634 16 ) ) -RRB- cord-015021-pol2qm74 634 17 is be VBZ cord-015021-pol2qm74 634 18 grown grow VBN cord-015021-pol2qm74 634 19 on on IN cord-015021-pol2qm74 634 20 a a DT cord-015021-pol2qm74 634 21 3 3 CD cord-015021-pol2qm74 634 22 micron micron NN cord-015021-pol2qm74 634 23 filter filter NN cord-015021-pol2qm74 634 24 in in IN cord-015021-pol2qm74 634 25 a a DT cord-015021-pol2qm74 634 26 two two CD cord-015021-pol2qm74 634 27 compartment compartment NN cord-015021-pol2qm74 634 28 system system NN cord-015021-pol2qm74 634 29 . . . cord-015021-pol2qm74 635 1 After after IN cord-015021-pol2qm74 635 2 tight tight JJ cord-015021-pol2qm74 635 3 junction junction NN cord-015021-pol2qm74 635 4 integrity integrity NN cord-015021-pol2qm74 635 5 is be VBZ cord-015021-pol2qm74 635 6 established establish VBN cord-015021-pol2qm74 635 7 , , , cord-015021-pol2qm74 635 8 bacteria bacteria NNS cord-015021-pol2qm74 635 9 are be VBP cord-015021-pol2qm74 635 10 placed place VBN cord-015021-pol2qm74 635 11 in in IN cord-015021-pol2qm74 635 12 the the DT cord-015021-pol2qm74 635 13 apical apical JJ cord-015021-pol2qm74 635 14 surface surface NN cord-015021-pol2qm74 635 15 chamber chamber NN cord-015021-pol2qm74 635 16 and and CC cord-015021-pol2qm74 635 17 BT BT NNP cord-015021-pol2qm74 635 18 across across IN cord-015021-pol2qm74 635 19 the the DT cord-015021-pol2qm74 635 20 Caco-2 caco-2 NN cord-015021-pol2qm74 635 21 monolayer monolayer NN cord-015021-pol2qm74 635 22 is be VBZ cord-015021-pol2qm74 635 23 measured measure VBN cord-015021-pol2qm74 635 24 by by IN cord-015021-pol2qm74 635 25 culturing culture VBG cord-015021-pol2qm74 635 26 the the DT cord-015021-pol2qm74 635 27 basal basal NN cord-015021-pol2qm74 635 28 chamber chamber NN cord-015021-pol2qm74 635 29 . . . cord-015021-pol2qm74 636 1 The the DT cord-015021-pol2qm74 636 2 results result NNS cord-015021-pol2qm74 636 3 of of IN cord-015021-pol2qm74 636 4 our -PRON- PRP$ cord-015021-pol2qm74 636 5 studies study NNS cord-015021-pol2qm74 636 6 utilizing utilize VBG cord-015021-pol2qm74 636 7 the the DT cord-015021-pol2qm74 636 8 Caco-2 Caco-2 NNP cord-015021-pol2qm74 636 9 system system NN cord-015021-pol2qm74 636 10 indicates indicate VBZ cord-015021-pol2qm74 636 11 that that IN cord-015021-pol2qm74 636 12 ; ; : cord-015021-pol2qm74 636 13 l l LS cord-015021-pol2qm74 636 14 ) ) -RRB- cord-015021-pol2qm74 636 15 Several several JJ cord-015021-pol2qm74 636 16 strains strain NNS cord-015021-pol2qm74 636 17 of of IN cord-015021-pol2qm74 636 18 non non JJ cord-015021-pol2qm74 636 19 - - JJ cord-015021-pol2qm74 636 20 pathogenic pathogenic JJ cord-015021-pol2qm74 636 21 bacteria bacteria NNS cord-015021-pol2qm74 636 22 will will MD cord-015021-pol2qm74 636 23 translocate translocate VB cord-015021-pol2qm74 636 24 across across IN cord-015021-pol2qm74 636 25 the the DT cord-015021-pol2qm74 636 26 Caco-2 Caco-2 NNP cord-015021-pol2qm74 636 27 monolayer monolayer NN cord-015021-pol2qm74 636 28 in in IN cord-015021-pol2qm74 636 29 a a DT cord-015021-pol2qm74 636 30 time time NN cord-015021-pol2qm74 636 31 - - HYPH cord-015021-pol2qm74 636 32 dependent dependent JJ cord-015021-pol2qm74 636 33 and and CC cord-015021-pol2qm74 636 34 dose dose NN cord-015021-pol2qm74 636 35 - - HYPH cord-015021-pol2qm74 636 36 dependent dependent JJ cord-015021-pol2qm74 636 37 fashion fashion NN cord-015021-pol2qm74 636 38 . . . cord-015021-pol2qm74 637 1 However however RB cord-015021-pol2qm74 637 2 , , , cord-015021-pol2qm74 637 3 the the DT cord-015021-pol2qm74 637 4 incidence incidence NN cord-015021-pol2qm74 637 5 and and CC cord-015021-pol2qm74 637 6 magnitude magnitude NN cord-015021-pol2qm74 637 7 of of IN cord-015021-pol2qm74 637 8 BT BT NNP cord-015021-pol2qm74 637 9 are be VBP cord-015021-pol2qm74 637 10 highest high JJS cord-015021-pol2qm74 637 11 for for IN cord-015021-pol2qm74 637 12 those those DT cord-015021-pol2qm74 637 13 strains strain NNS cord-015021-pol2qm74 637 14 of of IN cord-015021-pol2qm74 637 15 bacteria bacteria NNS cord-015021-pol2qm74 637 16 ( ( -LRB- cord-015021-pol2qm74 637 17 gram gram JJ cord-015021-pol2qm74 637 18 - - HYPH cord-015021-pol2qm74 637 19 negative negative JJ cord-015021-pol2qm74 637 20 enterics enteric NNS cord-015021-pol2qm74 637 21 ) ) -RRB- cord-015021-pol2qm74 637 22 that that WDT cord-015021-pol2qm74 637 23 are be VBP cord-015021-pol2qm74 637 24 most most RBS cord-015021-pol2qm74 637 25 commonly commonly RB cord-015021-pol2qm74 637 26 cultured culture VBN cord-015021-pol2qm74 637 27 in in IN cord-015021-pol2qm74 637 28 vivo vivo NN cord-015021-pol2qm74 637 29 . . . cord-015021-pol2qm74 638 1 2 2 LS cord-015021-pol2qm74 638 2 ) ) -RRB- cord-015021-pol2qm74 639 1 Caco-2 caco-2 NN cord-015021-pol2qm74 639 2 cells cell NNS cord-015021-pol2qm74 639 3 are be VBP cord-015021-pol2qm74 639 4 actively actively RB cord-015021-pol2qm74 639 5 involved involve VBN cord-015021-pol2qm74 639 6 in in IN cord-015021-pol2qm74 639 7 the the DT cord-015021-pol2qm74 639 8 transcellular transcellular JJ cord-015021-pol2qm74 639 9 passage passage NN cord-015021-pol2qm74 639 10 of of IN cord-015021-pol2qm74 639 11 bacteria bacteria NNS cord-015021-pol2qm74 639 12 across across IN cord-015021-pol2qm74 639 13 the the DT cord-015021-pol2qm74 639 14 Caco-2 Caco-2 NNP cord-015021-pol2qm74 639 15 monolayer monolayer NN cord-015021-pol2qm74 639 16 , , , cord-015021-pol2qm74 639 17 since since IN cord-015021-pol2qm74 639 18 inhibition inhibition NN cord-015021-pol2qm74 639 19 of of IN cord-015021-pol2qm74 639 20 Caco-2 Caco-2 NNP cord-015021-pol2qm74 639 21 microtubule microtubule NN cord-015021-pol2qm74 639 22 or or CC cord-015021-pol2qm74 639 23 microfilament microfilament NN cord-015021-pol2qm74 639 24 function function NN cord-015021-pol2qm74 639 25 decreases decrease VBZ cord-015021-pol2qm74 639 26 the the DT cord-015021-pol2qm74 639 27 magnitude magnitude NN cord-015021-pol2qm74 639 28 of of IN cord-015021-pol2qm74 639 29 ST ST NNP cord-015021-pol2qm74 639 30 . . . cord-015021-pol2qm74 640 1 3 3 LS cord-015021-pol2qm74 640 2 ) ) -RRB- cord-015021-pol2qm74 641 1 Lectin Lectin NNP cord-015021-pol2qm74 641 2 but but CC cord-015021-pol2qm74 641 3 not not RB cord-015021-pol2qm74 641 4 integrin integrin JJ cord-015021-pol2qm74 641 5 receptors receptor NNS cord-015021-pol2qm74 641 6 are be VBP cord-015021-pol2qm74 641 7 involved involve VBN cord-015021-pol2qm74 641 8 in in IN cord-015021-pol2qm74 641 9 bacterial bacterial JJ cord-015021-pol2qm74 641 10 translocation translocation NN cord-015021-pol2qm74 641 11 of of IN cord-015021-pol2qm74 641 12 E. E. NNP cord-015021-pol2qm74 641 13 col~ col~ NNP cord-015021-pol2qm74 641 14 across across IN cord-015021-pol2qm74 641 15 the the DT cord-015021-pol2qm74 641 16 Caco-2 Caco-2 NNP cord-015021-pol2qm74 641 17 cell cell NN cord-015021-pol2qm74 641 18 monolayer monolayer NN cord-015021-pol2qm74 641 19 . . . cord-015021-pol2qm74 642 1 4 4 LS cord-015021-pol2qm74 642 2 ) ) -RRB- cord-015021-pol2qm74 643 1 Caco-2 caco-2 NN cord-015021-pol2qm74 643 2 cells cell NNS cord-015021-pol2qm74 643 3 have have VBP cord-015021-pol2qm74 643 4 the the DT cord-015021-pol2qm74 643 5 ability ability NN cord-015021-pol2qm74 643 6 to to TO cord-015021-pol2qm74 643 7 ingest ingest VB cord-015021-pol2qm74 643 8 and and CC cord-015021-pol2qm74 643 9 kill kill VB cord-015021-pol2qm74 643 10 certain certain JJ cord-015021-pol2qm74 643 11 strains strain NNS cord-015021-pol2qm74 643 12 of of IN cord-015021-pol2qm74 643 13 bacteria bacteria NNS cord-015021-pol2qm74 643 14 . . . cord-015021-pol2qm74 644 1 The the DT cord-015021-pol2qm74 644 2 mechanisms mechanism NNS cord-015021-pol2qm74 644 3 involved involve VBN cord-015021-pol2qm74 644 4 in in IN cord-015021-pol2qm74 644 5 Caco-2 caco-2 NN cord-015021-pol2qm74 644 6 bactericidal bactericidal JJ cord-015021-pol2qm74 644 7 activity activity NN cord-015021-pol2qm74 644 8 appear appear VBP cord-015021-pol2qm74 644 9 similar similar JJ cord-015021-pol2qm74 644 10 to to IN cord-015021-pol2qm74 644 11 that that DT cord-015021-pol2qm74 644 12 of of IN cord-015021-pol2qm74 644 13 PMNs pmn NNS cord-015021-pol2qm74 644 14 to to IN cord-015021-pol2qm74 644 15 the the DT cord-015021-pol2qm74 644 16 extent extent NN cord-015021-pol2qm74 644 17 that that IN cord-015021-pol2qm74 644 18 both both DT cord-015021-pol2qm74 644 19 are be VBP cord-015021-pol2qm74 644 20 oxidant oxidant JJ cord-015021-pol2qm74 644 21 but but CC cord-015021-pol2qm74 644 22 not not RB cord-015021-pol2qm74 644 23 nitric nitric JJ cord-015021-pol2qm74 644 24 oxide oxide NN cord-015021-pol2qm74 644 25 mediated mediate VBN cord-015021-pol2qm74 644 26 . . . cord-015021-pol2qm74 645 1 These these DT cord-015021-pol2qm74 645 2 in in IN cord-015021-pol2qm74 645 3 vitro vitro FW cord-015021-pol2qm74 645 4 studies study NNS cord-015021-pol2qm74 645 5 suggest suggest VBP cord-015021-pol2qm74 645 6 that that IN cord-015021-pol2qm74 645 7 Caco-2 caco-2 NN cord-015021-pol2qm74 645 8 cells cell NNS cord-015021-pol2qm74 645 9 can can MD cord-015021-pol2qm74 645 10 function function VB cord-015021-pol2qm74 645 11 as as IN cord-015021-pol2qm74 645 12 " " `` cord-015021-pol2qm74 645 13 nonprofessional nonprofessional JJ cord-015021-pol2qm74 645 14 " " '' cord-015021-pol2qm74 645 15 phagocytes phagocyte NNS cord-015021-pol2qm74 645 16 and and CC cord-015021-pol2qm74 645 17 that that IN cord-015021-pol2qm74 645 18 both both DT cord-015021-pol2qm74 645 19 bacteria bacteria NNS cord-015021-pol2qm74 645 20 and and CC cord-015021-pol2qm74 645 21 enterocytes enterocyte NNS cord-015021-pol2qm74 645 22 are be VBP cord-015021-pol2qm74 645 23 involved involve VBN cord-015021-pol2qm74 645 24 in in IN cord-015021-pol2qm74 645 25 the the DT cord-015021-pol2qm74 645 26 translecation translecation NN cord-015021-pol2qm74 645 27 phenomenon phenomenon NN cord-015021-pol2qm74 645 28 . . . cord-015021-pol2qm74 646 1 Bacterial bacterial JJ cord-015021-pol2qm74 646 2 translocation translocation NN cord-015021-pol2qm74 646 3 due due IN cord-015021-pol2qm74 646 4 to to IN cord-015021-pol2qm74 646 5 gut gut VB cord-015021-pol2qm74 646 6 barrier barrier NN cord-015021-pol2qm74 646 7 dysfunction dysfunction NN cord-015021-pol2qm74 646 8 is be VBZ cord-015021-pol2qm74 646 9 considered consider VBN cord-015021-pol2qm74 646 10 to to TO cord-015021-pol2qm74 646 11 be be VB cord-015021-pol2qm74 646 12 a a DT cord-015021-pol2qm74 646 13 major major JJ cord-015021-pol2qm74 646 14 cause cause NN cord-015021-pol2qm74 646 15 of of IN cord-015021-pol2qm74 646 16 septic septic JJ cord-015021-pol2qm74 646 17 complications complication NNS cord-015021-pol2qm74 646 18 and and CC cord-015021-pol2qm74 646 19 multiple multiple JJ cord-015021-pol2qm74 646 20 organ organ NN cord-015021-pol2qm74 646 21 failure failure NN cord-015021-pol2qm74 646 22 following follow VBG cord-015021-pol2qm74 646 23 trauma trauma NN cord-015021-pol2qm74 646 24 , , , cord-015021-pol2qm74 646 25 burn burn VB cord-015021-pol2qm74 646 26 injury injury NN cord-015021-pol2qm74 646 27 , , , cord-015021-pol2qm74 646 28 hypoxia hypoxia NN cord-015021-pol2qm74 646 29 , , , cord-015021-pol2qm74 646 30 shock shock NN cord-015021-pol2qm74 646 31 and and CC cord-015021-pol2qm74 646 32 shock shock NN cord-015021-pol2qm74 646 33 - - HYPH cord-015021-pol2qm74 646 34 like like JJ cord-015021-pol2qm74 646 35 states state NNS cord-015021-pol2qm74 646 36 . . . cord-015021-pol2qm74 647 1 The the DT cord-015021-pol2qm74 647 2 invasion invasion NN cord-015021-pol2qm74 647 3 of of IN cord-015021-pol2qm74 647 4 bacteria bacteria NNS cord-015021-pol2qm74 647 5 into into IN cord-015021-pol2qm74 647 6 the the DT cord-015021-pol2qm74 647 7 circulation circulation NN cord-015021-pol2qm74 647 8 from from IN cord-015021-pol2qm74 647 9 the the DT cord-015021-pol2qm74 647 10 gastrointestinal gastrointestinal JJ cord-015021-pol2qm74 647 11 tract tract NN cord-015021-pol2qm74 647 12 or or CC cord-015021-pol2qm74 647 13 even even RB cord-015021-pol2qm74 647 14 from from IN cord-015021-pol2qm74 647 15 other other JJ cord-015021-pol2qm74 647 16 sources source NNS cord-015021-pol2qm74 647 17 , , , cord-015021-pol2qm74 647 18 however however RB cord-015021-pol2qm74 647 19 , , , cord-015021-pol2qm74 647 20 should should MD cord-015021-pol2qm74 647 21 not not RB cord-015021-pol2qm74 647 22 necessarily necessarily RB cord-015021-pol2qm74 647 23 result result VB cord-015021-pol2qm74 647 24 in in IN cord-015021-pol2qm74 647 25 systemic systemic JJ cord-015021-pol2qm74 647 26 infection infection NN cord-015021-pol2qm74 647 27 or or CC cord-015021-pol2qm74 647 28 organ organ NN cord-015021-pol2qm74 647 29 cohinisation cohinisation NN cord-015021-pol2qm74 647 30 , , , cord-015021-pol2qm74 647 31 as as RB cord-015021-pol2qm74 647 32 long long RB cord-015021-pol2qm74 647 33 as as IN cord-015021-pol2qm74 647 34 the the DT cord-015021-pol2qm74 647 35 humoral humoral JJ cord-015021-pol2qm74 647 36 and and CC cord-015021-pol2qm74 647 37 cellular cellular JJ cord-015021-pol2qm74 647 38 defense defense NN cord-015021-pol2qm74 647 39 mechanisms mechanism NNS cord-015021-pol2qm74 647 40 are be VBP cord-015021-pol2qm74 647 41 not not RB cord-015021-pol2qm74 647 42 impaired impaired JJ cord-015021-pol2qm74 647 43 . . . cord-015021-pol2qm74 648 1 Thus thus RB cord-015021-pol2qm74 648 2 , , , cord-015021-pol2qm74 648 3 a a DT cord-015021-pol2qm74 648 4 reduced reduce VBN cord-015021-pol2qm74 648 5 RES res NN cord-015021-pol2qm74 648 6 clearance clearance NN cord-015021-pol2qm74 648 7 capacity capacity NN cord-015021-pol2qm74 648 8 and and CC cord-015021-pol2qm74 648 9 hepatic hepatic JJ cord-015021-pol2qm74 648 10 clearance clearance NN cord-015021-pol2qm74 648 11 function function NN cord-015021-pol2qm74 648 12 of of IN cord-015021-pol2qm74 648 13 bacteria bacteria NNS cord-015021-pol2qm74 648 14 and and CC cord-015021-pol2qm74 648 15 toxins toxin NNS cord-015021-pol2qm74 648 16 can can MD cord-015021-pol2qm74 648 17 be be VB cord-015021-pol2qm74 648 18 observed observe VBN cord-015021-pol2qm74 648 19 under under IN cord-015021-pol2qm74 648 20 the the DT cord-015021-pol2qm74 648 21 same same JJ cord-015021-pol2qm74 648 22 conditions condition NNS cord-015021-pol2qm74 648 23 which which WDT cord-015021-pol2qm74 648 24 enable enable VBP cord-015021-pol2qm74 648 25 bacterial bacterial JJ cord-015021-pol2qm74 648 26 translocation translocation NN cord-015021-pol2qm74 648 27 from from IN cord-015021-pol2qm74 648 28 the the DT cord-015021-pol2qm74 648 29 gut gut NN cord-015021-pol2qm74 648 30 . . . cord-015021-pol2qm74 649 1 In in IN cord-015021-pol2qm74 649 2 order order NN cord-015021-pol2qm74 649 3 to to TO cord-015021-pol2qm74 649 4 evaluate evaluate VB cord-015021-pol2qm74 649 5 the the DT cord-015021-pol2qm74 649 6 influence influence NN cord-015021-pol2qm74 649 7 of of IN cord-015021-pol2qm74 649 8 circulatory circulatory JJ cord-015021-pol2qm74 649 9 , , , cord-015021-pol2qm74 649 10 metabolic metabolic JJ cord-015021-pol2qm74 649 11 and and CC cord-015021-pol2qm74 649 12 humorul humorul NNP cord-015021-pol2qm74 649 13 disorders disorder NNS cord-015021-pol2qm74 649 14 on on IN cord-015021-pol2qm74 649 15 the the DT cord-015021-pol2qm74 649 16 elimination elimination NN cord-015021-pol2qm74 649 17 of of IN cord-015021-pol2qm74 649 18 bacteria bacteria NNS cord-015021-pol2qm74 649 19 out out IN cord-015021-pol2qm74 649 20 of of IN cord-015021-pol2qm74 649 21 the the DT cord-015021-pol2qm74 649 22 blood blood NN cord-015021-pol2qm74 649 23 circulation circulation NN cord-015021-pol2qm74 649 24 , , , cord-015021-pol2qm74 649 25 a a DT cord-015021-pol2qm74 649 26 series series NN cord-015021-pol2qm74 649 27 of of IN cord-015021-pol2qm74 649 28 experiments experiment NNS cord-015021-pol2qm74 649 29 were be VBD cord-015021-pol2qm74 649 30 performed perform VBN cord-015021-pol2qm74 649 31 in in IN cord-015021-pol2qm74 649 32 anesthetized anesthetized JJ cord-015021-pol2qm74 649 33 and and CC cord-015021-pol2qm74 649 34 ventilated ventilate VBN cord-015021-pol2qm74 649 35 rabbits rabbit NNS cord-015021-pol2qm74 649 36 which which WDT cord-015021-pol2qm74 649 37 received receive VBD cord-015021-pol2qm74 649 38 defined define VBN cord-015021-pol2qm74 649 39 numbers number NNS cord-015021-pol2qm74 649 40 ( ( -LRB- cord-015021-pol2qm74 649 41 1.3 1.3 CD cord-015021-pol2qm74 649 42 x x SYM cord-015021-pol2qm74 649 43 108 108 CD cord-015021-pol2qm74 649 44 colony colony NN cord-015021-pol2qm74 649 45 - - HYPH cord-015021-pol2qm74 649 46 furming furme VBG cord-015021-pol2qm74 649 47 units unit NNS cord-015021-pol2qm74 649 48 ) ) -RRB- cord-015021-pol2qm74 649 49 of of IN cord-015021-pol2qm74 649 50 Escherichia Escherichia NNP cord-015021-pol2qm74 649 51 coli coli NNS cord-015021-pol2qm74 649 52 as as IN cord-015021-pol2qm74 649 53 a a DT cord-015021-pol2qm74 649 54 bolus bolus NN cord-015021-pol2qm74 649 55 injection injection NN cord-015021-pol2qm74 649 56 . . . cord-015021-pol2qm74 650 1 In in IN cord-015021-pol2qm74 650 2 unaffected unaffected JJ cord-015021-pol2qm74 650 3 control control NN cord-015021-pol2qm74 650 4 animals animal NNS cord-015021-pol2qm74 650 5 the the DT cord-015021-pol2qm74 650 6 intravenously intravenously RB cord-015021-pol2qm74 650 7 injected inject VBN cord-015021-pol2qm74 650 8 bacteria bacteria NNS cord-015021-pol2qm74 650 9 are be VBP cord-015021-pol2qm74 650 10 eliminated eliminate VBN cord-015021-pol2qm74 650 11 about about RB cord-015021-pol2qm74 650 12 99.9 99.9 CD cord-015021-pol2qm74 650 13 % % NN cord-015021-pol2qm74 650 14 within within IN cord-015021-pol2qm74 650 15 the the DT cord-015021-pol2qm74 650 16 first first JJ cord-015021-pol2qm74 650 17 15 15 CD cord-015021-pol2qm74 650 18 minutes minute NNS cord-015021-pol2qm74 650 19 and and CC cord-015021-pol2qm74 650 20 are be VBP cord-015021-pol2qm74 650 21 totaiy totaiy VBN cord-015021-pol2qm74 650 22 cleared clear VBN cord-015021-pol2qm74 650 23 within within IN cord-015021-pol2qm74 650 24 90 90 CD cord-015021-pol2qm74 650 25 minutes minute NNS cord-015021-pol2qm74 650 26 . . . cord-015021-pol2qm74 651 1 57 57 CD cord-015021-pol2qm74 651 2 % % NN cord-015021-pol2qm74 651 3 offue offue NNP cord-015021-pol2qm74 651 4 total total JJ cord-015021-pol2qm74 651 5 CFU CFU NNP cord-015021-pol2qm74 651 6 counted count VBD cord-015021-pol2qm74 651 7 in in IN cord-015021-pol2qm74 651 8 the the DT cord-015021-pol2qm74 651 9 cultures culture NNS cord-015021-pol2qm74 651 10 of of IN cord-015021-pol2qm74 651 11 the the DT cord-015021-pol2qm74 651 12 organ organ NN cord-015021-pol2qm74 651 13 homogenates homogenate NNS cord-015021-pol2qm74 651 14 were be VBD cord-015021-pol2qm74 651 15 found find VBN cord-015021-pol2qm74 651 16 in in IN cord-015021-pol2qm74 651 17 liver liver NN cord-015021-pol2qm74 651 18 and and CC cord-015021-pol2qm74 651 19 spleen spleen NNS cord-015021-pol2qm74 651 20 , , , cord-015021-pol2qm74 651 21 whereas whereas IN cord-015021-pol2qm74 651 22 only only RB cord-015021-pol2qm74 651 23 very very RB cord-015021-pol2qm74 651 24 low low JJ cord-015021-pol2qm74 651 25 numbers number NNS cord-015021-pol2qm74 651 26 could could MD cord-015021-pol2qm74 651 27 be be VB cord-015021-pol2qm74 651 28 detected detect VBN cord-015021-pol2qm74 651 29 in in IN cord-015021-pol2qm74 651 30 the the DT cord-015021-pol2qm74 651 31 lungs lung NNS cord-015021-pol2qm74 651 32 and and CC cord-015021-pol2qm74 651 33 kidneys kidney NNS cord-015021-pol2qm74 651 34 . . . cord-015021-pol2qm74 652 1 Systemic systemic JJ cord-015021-pol2qm74 652 2 injury injury NN cord-015021-pol2qm74 652 3 of of IN cord-015021-pol2qm74 652 4 the the DT cord-015021-pol2qm74 652 5 animals animal NNS cord-015021-pol2qm74 652 6 by by IN cord-015021-pol2qm74 652 7 hemorrhagic hemorrhagic JJ cord-015021-pol2qm74 652 8 shock shock NN cord-015021-pol2qm74 652 9 , , , cord-015021-pol2qm74 652 10 endotoxinemia endotoxinemia NN cord-015021-pol2qm74 652 11 , , , cord-015021-pol2qm74 652 12 hypoxia hypoxia NN cord-015021-pol2qm74 652 13 , , , cord-015021-pol2qm74 652 14 coagulation coagulation NN cord-015021-pol2qm74 652 15 disorder disorder NN cord-015021-pol2qm74 652 16 , , , cord-015021-pol2qm74 652 17 systemic systemic JJ cord-015021-pol2qm74 652 18 vasoconstriction vasoconstriction NN cord-015021-pol2qm74 652 19 by by IN cord-015021-pol2qm74 652 20 norepinephrine norepinephrine NN cord-015021-pol2qm74 652 21 and and CC cord-015021-pol2qm74 652 22 other other JJ cord-015021-pol2qm74 652 23 types type NNS cord-015021-pol2qm74 652 24 of of IN cord-015021-pol2qm74 652 25 injury injury NN cord-015021-pol2qm74 652 26 reduced reduce VBD cord-015021-pol2qm74 652 27 the the DT cord-015021-pol2qm74 652 28 elimination elimination NN cord-015021-pol2qm74 652 29 rate rate NN cord-015021-pol2qm74 652 30 of of IN cord-015021-pol2qm74 652 31 bacteria bacteria NNS cord-015021-pol2qm74 652 32 and and CC cord-015021-pol2qm74 652 33 changed change VBD cord-015021-pol2qm74 652 34 the the DT cord-015021-pol2qm74 652 35 pattern pattern NN cord-015021-pol2qm74 652 36 and and CC cord-015021-pol2qm74 652 37 degree degree NN cord-015021-pol2qm74 652 38 of of IN cord-015021-pol2qm74 652 39 their -PRON- PRP$ cord-015021-pol2qm74 652 40 dissemination dissemination NN cord-015021-pol2qm74 652 41 and and CC cord-015021-pol2qm74 652 42 tissue tissue NN cord-015021-pol2qm74 652 43 distribution distribution NN cord-015021-pol2qm74 652 44 . . . cord-015021-pol2qm74 653 1 The the DT cord-015021-pol2qm74 653 2 bacterial bacterial JJ cord-015021-pol2qm74 653 3 clearance clearance NN cord-015021-pol2qm74 653 4 was be VBD cord-015021-pol2qm74 653 5 delayed delay VBN cord-015021-pol2qm74 653 6 mostly mostly RB cord-015021-pol2qm74 653 7 in in IN cord-015021-pol2qm74 653 8 rabbits rabbit NNS cord-015021-pol2qm74 653 9 subjected subject VBN cord-015021-pol2qm74 653 10 to to IN cord-015021-pol2qm74 653 11 hypoxemic hypoxemic JJ cord-015021-pol2qm74 653 12 hypoxia hypoxia NN cord-015021-pol2qm74 653 13 in in IN cord-015021-pol2qm74 653 14 which which WDT cord-015021-pol2qm74 653 15 about about RB cord-015021-pol2qm74 653 16 100 100 CD cord-015021-pol2qm74 653 17 CFU CFU NNS cord-015021-pol2qm74 653 18 of of IN cord-015021-pol2qm74 653 19 viable viable JJ cord-015021-pol2qm74 653 20 E.eoli E.eoli NNS cord-015021-pol2qm74 653 21 per per IN cord-015021-pol2qm74 653 22 ml ml NN cord-015021-pol2qm74 653 23 blood blood NN cord-015021-pol2qm74 653 24 could could MD cord-015021-pol2qm74 653 25 still still RB cord-015021-pol2qm74 653 26 be be VB cord-015021-pol2qm74 653 27 counted count VBN cord-015021-pol2qm74 653 28 3 3 CD cord-015021-pol2qm74 653 29 hours hour NNS cord-015021-pol2qm74 653 30 following follow VBG cord-015021-pol2qm74 653 31 their -PRON- PRP$ cord-015021-pol2qm74 653 32 injection injection NN cord-015021-pol2qm74 653 33 . . . cord-015021-pol2qm74 654 1 The the DT cord-015021-pol2qm74 654 2 number number NN cord-015021-pol2qm74 654 3 of of IN cord-015021-pol2qm74 654 4 viable viable JJ cord-015021-pol2qm74 654 5 bacteria bacteria NNS cord-015021-pol2qm74 654 6 was be VBD cord-015021-pol2qm74 654 7 some some DT cord-015021-pol2qm74 654 8 ten ten CD cord-015021-pol2qm74 654 9 powers power NNS cord-015021-pol2qm74 654 10 higher higher RBR cord-015021-pol2qm74 654 11 in in IN cord-015021-pol2qm74 654 12 organs organ NNS cord-015021-pol2qm74 654 13 of of IN cord-015021-pol2qm74 654 14 hypoxic hypoxic JJ cord-015021-pol2qm74 654 15 rabbits rabbit NNS cord-015021-pol2qm74 654 16 in in IN cord-015021-pol2qm74 654 17 comparison comparison NN cord-015021-pol2qm74 654 18 to to TO cord-015021-pol2qm74 654 19 control control VB cord-015021-pol2qm74 654 20 ardmais ardmais NNP cord-015021-pol2qm74 654 21 , , , cord-015021-pol2qm74 654 22 and and CC cord-015021-pol2qm74 654 23 an an DT cord-015021-pol2qm74 654 24 excessive excessive JJ cord-015021-pol2qm74 654 25 colonisation colonisation NN cord-015021-pol2qm74 654 26 of of IN cord-015021-pol2qm74 654 27 the the DT cord-015021-pol2qm74 654 28 lungs lung NNS cord-015021-pol2qm74 654 29 and and CC cord-015021-pol2qm74 654 30 kidneys kidney NNS cord-015021-pol2qm74 654 31 with with IN cord-015021-pol2qm74 654 32 25 25 CD cord-015021-pol2qm74 654 33 % % NN cord-015021-pol2qm74 654 34 respectively respectively RB cord-015021-pol2qm74 654 35 11 11 CD cord-015021-pol2qm74 654 36 % % NN cord-015021-pol2qm74 654 37 of of IN cord-015021-pol2qm74 654 38 the the DT cord-015021-pol2qm74 654 39 total total JJ cord-015021-pol2qm74 654 40 CFU CFU NNP cord-015021-pol2qm74 654 41 of of IN cord-015021-pol2qm74 654 42 the the DT cord-015021-pol2qm74 654 43 cultared cultared JJ cord-015021-pol2qm74 654 44 organ organ NN cord-015021-pol2qm74 654 45 homoganates homoganates NNPS cord-015021-pol2qm74 654 46 was be VBD cord-015021-pol2qm74 654 47 observed observe VBN cord-015021-pol2qm74 654 48 . . . cord-015021-pol2qm74 655 1 Unilateral unilateral JJ cord-015021-pol2qm74 655 2 iscbemia iscbemia NN cord-015021-pol2qm74 655 3 of of IN cord-015021-pol2qm74 655 4 the the DT cord-015021-pol2qm74 655 5 kidney kidney NN cord-015021-pol2qm74 655 6 prior prior RB cord-015021-pol2qm74 655 7 to to IN cord-015021-pol2qm74 655 8 the the DT cord-015021-pol2qm74 655 9 intravenous intravenous JJ cord-015021-pol2qm74 655 10 injection injection NN cord-015021-pol2qm74 655 11 of of IN cord-015021-pol2qm74 655 12 E.coli E.coli NNS cord-015021-pol2qm74 655 13 only only RB cord-015021-pol2qm74 655 14 moderately moderately RB cord-015021-pol2qm74 655 15 delayed delay VBD cord-015021-pol2qm74 655 16 the the DT cord-015021-pol2qm74 655 17 bacterial bacterial JJ cord-015021-pol2qm74 655 18 clearance clearance NN cord-015021-pol2qm74 655 19 , , , cord-015021-pol2qm74 655 20 bowever bowever NNP cord-015021-pol2qm74 655 21 , , , cord-015021-pol2qm74 655 22 caused cause VBD cord-015021-pol2qm74 655 23 an an DT cord-015021-pol2qm74 655 24 intense intense JJ cord-015021-pol2qm74 655 25 eohinisation eohinisation NN cord-015021-pol2qm74 655 26 of of IN cord-015021-pol2qm74 655 27 the the DT cord-015021-pol2qm74 655 28 affected affected JJ cord-015021-pol2qm74 655 29 reperfused reperfused JJ cord-015021-pol2qm74 655 30 organ organ NN cord-015021-pol2qm74 655 31 . . . cord-015021-pol2qm74 656 1 In in IN cord-015021-pol2qm74 656 2 contrast contrast NN cord-015021-pol2qm74 656 3 to to IN cord-015021-pol2qm74 656 4 this this DT cord-015021-pol2qm74 656 5 , , , cord-015021-pol2qm74 656 6 inhalation inhalation NN cord-015021-pol2qm74 656 7 injury injury NN cord-015021-pol2qm74 656 8 did do VBD cord-015021-pol2qm74 656 9 not not RB cord-015021-pol2qm74 656 10 promote promote VB cord-015021-pol2qm74 656 11 the the DT cord-015021-pol2qm74 656 12 accumulation accumulation NN cord-015021-pol2qm74 656 13 of of IN cord-015021-pol2qm74 656 14 bacteria bacteria NNS cord-015021-pol2qm74 656 15 in in IN cord-015021-pol2qm74 656 16 the the DT cord-015021-pol2qm74 656 17 lungs lung NNS cord-015021-pol2qm74 656 18 . . . cord-015021-pol2qm74 657 1 Conclusion conclusion NN cord-015021-pol2qm74 657 2 : : : cord-015021-pol2qm74 657 3 Shock shock NN cord-015021-pol2qm74 657 4 , , , cord-015021-pol2qm74 657 5 systemic systemic JJ cord-015021-pol2qm74 657 6 and and CC cord-015021-pol2qm74 657 7 local local JJ cord-015021-pol2qm74 657 8 affections affection NNS cord-015021-pol2qm74 657 9 reduce reduce VBP cord-015021-pol2qm74 657 10 the the DT cord-015021-pol2qm74 657 11 clearance clearance NN cord-015021-pol2qm74 657 12 of of IN cord-015021-pol2qm74 657 13 bacteria bacteria NNS cord-015021-pol2qm74 657 14 from from IN cord-015021-pol2qm74 657 15 the the DT cord-015021-pol2qm74 657 16 blood blood NN cord-015021-pol2qm74 657 17 circulation circulation NN cord-015021-pol2qm74 657 18 and and CC cord-015021-pol2qm74 657 19 enable enable VB cord-015021-pol2qm74 657 20 their -PRON- PRP$ cord-015021-pol2qm74 657 21 dissemination dissemination NN cord-015021-pol2qm74 657 22 and and CC cord-015021-pol2qm74 657 23 accumulation accumulation NN cord-015021-pol2qm74 657 24 in in IN cord-015021-pol2qm74 657 25 vital vital JJ cord-015021-pol2qm74 657 26 organs organ NNS cord-015021-pol2qm74 657 27 . . . cord-015021-pol2qm74 658 1 The the DT cord-015021-pol2qm74 658 2 degree degree NN cord-015021-pol2qm74 658 3 of of IN cord-015021-pol2qm74 658 4 this this DT cord-015021-pol2qm74 658 5 reduction reduction NN cord-015021-pol2qm74 658 6 and and CC cord-015021-pol2qm74 658 7 the the DT cord-015021-pol2qm74 658 8 organ organ NN cord-015021-pol2qm74 658 9 pattern pattern NN cord-015021-pol2qm74 658 10 of of IN cord-015021-pol2qm74 658 11 the the DT cord-015021-pol2qm74 658 12 bacterial bacterial JJ cord-015021-pol2qm74 658 13 distribution distribution NN cord-015021-pol2qm74 658 14 varies vary VBZ cord-015021-pol2qm74 658 15 with with IN cord-015021-pol2qm74 658 16 the the DT cord-015021-pol2qm74 658 17 type type NN cord-015021-pol2qm74 658 18 of of IN cord-015021-pol2qm74 658 19 injury injury NN cord-015021-pol2qm74 658 20 . . . cord-015021-pol2qm74 659 1 Thus thus RB cord-015021-pol2qm74 659 2 , , , cord-015021-pol2qm74 659 3 these these DT cord-015021-pol2qm74 659 4 factors factor NNS cord-015021-pol2qm74 659 5 seem seem VBP cord-015021-pol2qm74 659 6 to to TO cord-015021-pol2qm74 659 7 be be VB cord-015021-pol2qm74 659 8 essentially essentially RB cord-015021-pol2qm74 659 9 involved involve VBN cord-015021-pol2qm74 659 10 whether whether IN cord-015021-pol2qm74 659 11 or or CC cord-015021-pol2qm74 659 12 not not RB cord-015021-pol2qm74 659 13 bacterial bacterial JJ cord-015021-pol2qm74 659 14 translocation translocation NN cord-015021-pol2qm74 659 15 and and CC cord-015021-pol2qm74 659 16 multiple multiple JJ cord-015021-pol2qm74 659 17 organ organ NN cord-015021-pol2qm74 659 18 failure failure NN cord-015021-pol2qm74 659 19 will will MD cord-015021-pol2qm74 659 20 follow follow VB cord-015021-pol2qm74 659 21 the the DT cord-015021-pol2qm74 659 22 invasion invasion NN cord-015021-pol2qm74 659 23 of of IN cord-015021-pol2qm74 659 24 bacteria bacteria NNS cord-015021-pol2qm74 659 25 into into IN cord-015021-pol2qm74 659 26 the the DT cord-015021-pol2qm74 659 27 circulation circulation NN cord-015021-pol2qm74 659 28 as as IN cord-015021-pol2qm74 659 29 in in IN cord-015021-pol2qm74 659 30 the the DT cord-015021-pol2qm74 659 31 ease ease NN cord-015021-pol2qm74 659 32 of of IN cord-015021-pol2qm74 659 33 gut gut NN cord-015021-pol2qm74 659 34 barrier barrier NN cord-015021-pol2qm74 659 35 dysfunction dysfunction NN cord-015021-pol2qm74 659 36 . . . cord-015021-pol2qm74 660 1 Movement movement NN cord-015021-pol2qm74 660 2 of of IN cord-015021-pol2qm74 660 3 enteric enteric JJ cord-015021-pol2qm74 660 4 baaterla baaterla NN cord-015021-pol2qm74 660 5 from from IN cord-015021-pol2qm74 660 6 gut gut NN cord-015021-pol2qm74 660 7 to to IN cord-015021-pol2qm74 660 8 extralumeaal extralumeaal NN cord-015021-pol2qm74 660 9 sites site NNS cord-015021-pol2qm74 660 10 ( ( -LRB- cord-015021-pol2qm74 660 11 bacterial bacterial JJ cord-015021-pol2qm74 660 12 tra tra NN cord-015021-pol2qm74 660 13 ~ ~ CD cord-015021-pol2qm74 660 14 sloeation sloeation NN cord-015021-pol2qm74 660 15 ) ) -RRB- cord-015021-pol2qm74 660 16 m m NNP cord-015021-pol2qm74 660 17 ~ ~ NNP cord-015021-pol2qm74 660 18 y y NNP cord-015021-pol2qm74 660 19 play play VBP cord-015021-pol2qm74 660 20 a a DT cord-015021-pol2qm74 660 21 role role NN cord-015021-pol2qm74 660 22 ~. ~. . cord-015021-pol2qm74 661 1 nraltipl~ nraltipl~ NN cord-015021-pol2qm74 662 1 orga~ orga~ NNP cord-015021-pol2qm74 662 2 failure failure NN cord-015021-pol2qm74 662 3 . . . cord-015021-pol2qm74 663 1 Traumatic traumatic JJ cord-015021-pol2qm74 663 2 stress stress NN cord-015021-pol2qm74 663 3 ( ( -LRB- cord-015021-pol2qm74 663 4 shock shock NN cord-015021-pol2qm74 663 5 , , , cord-015021-pol2qm74 663 6 hffectiort hffectiort NNP cord-015021-pol2qm74 663 7 , , , cord-015021-pol2qm74 663 8 and and CC cord-015021-pol2qm74 663 9 im im UH cord-015021-pol2qm74 663 10 ~ ~ NFP cord-015021-pol2qm74 663 11 lammation lammation NN cord-015021-pol2qm74 663 12 ) ) -RRB- cord-015021-pol2qm74 663 13 and and CC cord-015021-pol2qm74 663 14 severe severe JJ cord-015021-pol2qm74 663 15 illness illness NN cord-015021-pol2qm74 663 16 are be VBP cord-015021-pol2qm74 663 17 common common JJ cord-015021-pol2qm74 663 18 alateeedents alateeedent NNS cord-015021-pol2qm74 663 19 . . . cord-015021-pol2qm74 664 1 Tnt Tnt NNP cord-015021-pol2qm74 665 1 ~st ~st NNP cord-015021-pol2qm74 665 2 ~ ~ NFP cord-015021-pol2qm74 665 3 aal aal NNP cord-015021-pol2qm74 665 4 Lleus Lleus NNP cord-015021-pol2qm74 665 5 is be VBZ cord-015021-pol2qm74 665 6 e e DT cord-015021-pol2qm74 665 7 common common JJ cord-015021-pol2qm74 665 8 proximme proximme JJ cord-015021-pol2qm74 665 9 causal causal JJ cord-015021-pol2qm74 665 10 factor factor NN cord-015021-pol2qm74 665 11 . . . cord-015021-pol2qm74 666 1 We -PRON- PRP cord-015021-pol2qm74 666 2 have have VBP cord-015021-pol2qm74 666 3 exanlined exanline VBN cord-015021-pol2qm74 666 4 the the DT cord-015021-pol2qm74 666 5 hypothesis hypothesis NN cord-015021-pol2qm74 666 6 that that IN cord-015021-pol2qm74 666 7 bacterial bacterial JJ cord-015021-pol2qm74 666 8 ttanslecation ttanslecation NN cord-015021-pol2qm74 666 9 from from IN cord-015021-pol2qm74 666 10 the the DT cord-015021-pol2qm74 666 11 gut gut NN cord-015021-pol2qm74 666 12 in in IN cord-015021-pol2qm74 666 13 expe expe NNS cord-015021-pol2qm74 666 14 ~ ~ NFP cord-015021-pol2qm74 666 15 me -PRON- PRP cord-015021-pol2qm74 666 16 ~ ~ NFP cord-015021-pol2qm74 666 17 tal tal NNP cord-015021-pol2qm74 666 18 paaerestitis paaerestitis NNP cord-015021-pol2qm74 666 19 is be VBZ cord-015021-pol2qm74 666 20 due due JJ cord-015021-pol2qm74 666 21 to to IN cord-015021-pol2qm74 666 22 bacterial bacterial JJ cord-015021-pol2qm74 666 23 overgrowth overgrowth NN cord-015021-pol2qm74 666 24 as as IN cord-015021-pol2qm74 666 25 a a DT cord-015021-pol2qm74 666 26 cuas cua NNS cord-015021-pol2qm74 666 27 ~ ~ NFP cord-015021-pol2qm74 666 28 ucnee ucnee NN cord-015021-pol2qm74 666 29 of of IN cord-015021-pol2qm74 666 30 a a DT cord-015021-pol2qm74 666 31 deere deere NNP cord-015021-pol2qm74 666 32 ~ ~ NFP cord-015021-pol2qm74 666 33 ae ae NNP cord-015021-pol2qm74 666 34 in in IN cord-015021-pol2qm74 666 35 intestinal intestinal JJ cord-015021-pol2qm74 666 36 transit transit NN cord-015021-pol2qm74 666 37 . . . cord-015021-pol2qm74 667 1 Ne Ne NNP cord-015021-pol2qm74 668 1 ~rotiT_.~g ~rotiT_.~g NFP cord-015021-pol2qm74 669 1 pancreatitls pancreatitls NNP cord-015021-pol2qm74 669 2 fblIowlng fblIowlng . cord-015021-pol2qm74 670 1 bile bile NN cord-015021-pol2qm74 670 2 duct duct NN cord-015021-pol2qm74 670 3 iigation iigation NN cord-015021-pol2qm74 670 4 in in IN cord-015021-pol2qm74 670 5 the the DT cord-015021-pol2qm74 670 6 opossum opossum NN cord-015021-pol2qm74 670 7 is be VBZ cord-015021-pol2qm74 670 8 associated associate VBN cord-015021-pol2qm74 670 9 with with IN cord-015021-pol2qm74 670 10 colonization colonization NN cord-015021-pol2qm74 670 11 of of IN cord-015021-pol2qm74 670 12 the the DT cord-015021-pol2qm74 670 13 pa pa NNP cord-015021-pol2qm74 670 14 , , , cord-015021-pol2qm74 670 15 se se NNP cord-015021-pol2qm74 670 16 ~re ~re NNP cord-015021-pol2qm74 670 17 , , , cord-015021-pol2qm74 670 18 aa aa NNP cord-015021-pol2qm74 670 19 by by IN cord-015021-pol2qm74 670 20 gut gut NN cord-015021-pol2qm74 670 21 derived derive VBN cord-015021-pol2qm74 670 22 organisms organism NNS cord-015021-pol2qm74 670 23 or or CC cord-015021-pol2qm74 670 24 salmonella salmonella NN cord-015021-pol2qm74 670 25 of of IN cord-015021-pol2qm74 670 26 bilJary biljary JJ cord-015021-pol2qm74 670 27 origin origin NN cord-015021-pol2qm74 670 28 in in IN cord-015021-pol2qm74 670 29 infected infected JJ cord-015021-pol2qm74 670 30 animals animal NNS cord-015021-pol2qm74 670 31 ( ( -LRB- cord-015021-pol2qm74 670 32 previously previously RB cord-015021-pol2qm74 670 33 reported report VBN cord-015021-pol2qm74 670 34 ) ) -RRB- cord-015021-pol2qm74 670 35 . . . cord-015021-pol2qm74 671 1 To to IN cord-015021-pol2qm74 671 2 ti ti NNP cord-015021-pol2qm74 671 3 ~ ~ NNP cord-015021-pol2qm74 671 4 rther rther NNP cord-015021-pol2qm74 671 5 define define VBP cord-015021-pol2qm74 671 6 the the DT cord-015021-pol2qm74 671 7 mechanism mechanism NN cord-015021-pol2qm74 671 8 of of IN cord-015021-pol2qm74 671 9 transloemdon transloemdon NN cord-015021-pol2qm74 671 10 in in IN cord-015021-pol2qm74 671 11 panereati panereati NNP cord-015021-pol2qm74 671 12 * * NFP cord-015021-pol2qm74 672 1 inflammation inflammation NN cord-015021-pol2qm74 673 1 , , , cord-015021-pol2qm74 673 2 pancteatitis pancteatitis NNP cord-015021-pol2qm74 673 3 was be VBD cord-015021-pol2qm74 673 4 induced induce VBN cord-015021-pol2qm74 673 5 hy hy NNP cord-015021-pol2qm74 673 6 iigatlon iigatlon NNP cord-015021-pol2qm74 673 7 of of IN cord-015021-pol2qm74 673 8 t t NNP cord-015021-pol2qm74 673 9 ~ ~ NFP cord-015021-pol2qm74 673 10 e e XX cord-015021-pol2qm74 673 11 lower low JJR cord-015021-pol2qm74 673 12 bile bile NN cord-015021-pol2qm74 673 13 duet duet NN cord-015021-pol2qm74 673 14 distal distal IN cord-015021-pol2qm74 673 15 to to IN cord-015021-pol2qm74 673 16 the the DT cord-015021-pol2qm74 673 17 pancreatic pancreatic JJ cord-015021-pol2qm74 673 18 duets duet NNS cord-015021-pol2qm74 673 19 m m VBP cord-015021-pol2qm74 673 20 the the DT cord-015021-pol2qm74 673 21 rat rat NN cord-015021-pol2qm74 673 22 . . . cord-015021-pol2qm74 674 1 Intestinal intestinal JJ cord-015021-pol2qm74 674 2 transit transit NN cord-015021-pol2qm74 674 3 , , , cord-015021-pol2qm74 674 4 enteric enteric JJ cord-015021-pol2qm74 674 5 bacteriology bacteriology NN cord-015021-pol2qm74 674 6 , , , cord-015021-pol2qm74 674 7 and and CC cord-015021-pol2qm74 674 8 tromsloeatien tromsloeatien NNP cord-015021-pol2qm74 674 9 of of IN cord-015021-pol2qm74 674 10 bacteria bacteria NNS cord-015021-pol2qm74 674 11 to to IN cord-015021-pol2qm74 674 12 mesanterie mesanterie NNP cord-015021-pol2qm74 674 13 lymph lymph NN cord-015021-pol2qm74 674 14 nodes node NNS cord-015021-pol2qm74 674 15 , , , cord-015021-pol2qm74 674 16 blood blood NN cord-015021-pol2qm74 674 17 stream stream NN cord-015021-pol2qm74 674 18 and and CC cord-015021-pol2qm74 674 19 splanelmie splanelmie NNP cord-015021-pol2qm74 674 20 organs organ NNS cord-015021-pol2qm74 675 1 wen wen NNP cord-015021-pol2qm74 675 2 deletmhaed deletmhaed NNP cord-015021-pol2qm74 675 3 at at IN cord-015021-pol2qm74 675 4 24 24 CD cord-015021-pol2qm74 675 5 ( ( -LRB- cord-015021-pol2qm74 675 6 n~ n~ NNP cord-015021-pol2qm74 675 7 7 7 CD cord-015021-pol2qm74 675 8 ) ) -RRB- cord-015021-pol2qm74 675 9 , , , cord-015021-pol2qm74 675 10 4 4 CD cord-015021-pol2qm74 675 11 g g NN cord-015021-pol2qm74 675 12 ( ( -LRB- cord-015021-pol2qm74 675 13 n n NN cord-015021-pol2qm74 675 14 ~ ~ CD cord-015021-pol2qm74 675 15 10 10 CD cord-015021-pol2qm74 675 16 ) ) -RRB- cord-015021-pol2qm74 675 17 , , , cord-015021-pol2qm74 675 18 and and CC cord-015021-pol2qm74 675 19 96 96 CD cord-015021-pol2qm74 676 1 ( ( -LRB- cord-015021-pol2qm74 676 2 n~ n~ $ cord-015021-pol2qm74 676 3 10 10 CD cord-015021-pol2qm74 676 4 ) ) -RRB- cord-015021-pol2qm74 676 5 hours hour NNS cord-015021-pol2qm74 676 6 with with IN cord-015021-pol2qm74 676 7 the the DT cord-015021-pol2qm74 676 8 fallowing fallowe VBG cord-015021-pol2qm74 676 9 results result NNS cord-015021-pol2qm74 676 10 : : : cord-015021-pol2qm74 676 11 lY ly XX cord-015021-pol2qm74 676 12 ~ ~ NFP cord-015021-pol2qm74 676 13 TESTINAI, testinai, CD cord-015021-pol2qm74 676 14 .. .. . cord-015021-pol2qm74 676 15 TRANSFI TRANSFI NNP cord-015021-pol2qm74 676 16 " " '' cord-015021-pol2qm74 676 17 . . . cord-015021-pol2qm74 677 1 Geometric geometric JJ cord-015021-pol2qm74 677 2 Mean Mean NNP cord-015021-pol2qm74 677 3 of of IN cord-015021-pol2qm74 677 4 Fluorescent Fluorescent NNP cord-015021-pol2qm74 677 5 Marker Marker NNP cord-015021-pol2qm74 677 6 -25 -25 '' cord-015021-pol2qm74 677 7 % % NN cord-015021-pol2qm74 677 8 at at IN cord-015021-pol2qm74 677 9 24 24 CD cord-015021-pol2qm74 677 10 hour~ hour~ NN cord-015021-pol2qm74 677 11 with with IN cord-015021-pol2qm74 677 12 return return NN cord-015021-pol2qm74 677 13 to to IN cord-015021-pol2qm74 677 14 51 51 CD cord-015021-pol2qm74 677 15 % % NN cord-015021-pol2qm74 677 16 of of IN cord-015021-pol2qm74 677 17 gut gut NN cord-015021-pol2qm74 677 18 leugth leugth NNP cord-015021-pol2qm74 677 19 ( ( -LRB- cord-015021-pol2qm74 677 20 similar similar JJ cord-015021-pol2qm74 677 21 to to IN cord-015021-pol2qm74 677 22 ~m ~m NNP cord-015021-pol2qm74 677 23 ) ) -RRB- cord-015021-pol2qm74 678 1 at at IN cord-015021-pol2qm74 678 2 96 96 CD cord-015021-pol2qm74 678 3 hour~. hour~. ADD cord-015021-pol2qm74 678 4 BACTERIAL BACTERIAL NNP cord-015021-pol2qm74 678 5 OVERGROWT_Hff OVERGROWT_Hff NNPS cord-015021-pol2qm74 678 6 -Increase -Increase : cord-015021-pol2qm74 678 7 in in IN cord-015021-pol2qm74 678 8 total total JJ cord-015021-pol2qm74 678 9 bsctetia bsctetia NN cord-015021-pol2qm74 679 1 ~ad ~ad NNP cord-015021-pol2qm74 679 2 gram gram NN cord-015021-pol2qm74 679 3 negative negative JJ cord-015021-pol2qm74 679 4 rod.~ rod.~ NNS cord-015021-pol2qm74 679 5 at at IN cord-015021-pol2qm74 679 6 2 2 CD cord-015021-pol2qm74 679 7 , , , cord-015021-pol2qm74 679 8 ; ; : cord-015021-pol2qm74 679 9 hours hour NNS cord-015021-pol2qm74 679 10 with with IN cord-015021-pol2qm74 679 11 return return NN cord-015021-pol2qm74 679 12 to to IN cord-015021-pol2qm74 679 13 sham sham JJ cord-015021-pol2qm74 679 14 control control NN cord-015021-pol2qm74 679 15 at at IN cord-015021-pol2qm74 679 16 96 96 CD cord-015021-pol2qm74 679 17 hours hour NNS cord-015021-pol2qm74 679 18 ( ( -LRB- cord-015021-pol2qm74 679 19 9 9 CD cord-015021-pol2qm74 679 20 Log Log NNP cord-015021-pol2qm74 679 21 CFU CFU NNP cord-015021-pol2qm74 679 22 / / SYM cord-015021-pol2qm74 679 23 g g NN cord-015021-pol2qm74 679 24 veraus veraus NNP cord-015021-pol2qm74 679 25 6 6 CD cord-015021-pol2qm74 679 26 Log Log NNP cord-015021-pol2qm74 679 27 CFU CFU NNP cord-015021-pol2qm74 679 28 / / SYM cord-015021-pol2qm74 679 29 g g NNP cord-015021-pol2qm74 679 30 ia ia NNP cord-015021-pol2qm74 679 31 ileum ileum NNP cord-015021-pol2qm74 679 32 ) ) -RRB- cord-015021-pol2qm74 679 33 . . . cord-015021-pol2qm74 680 1 TRANSLOCATION TRANSLOCATION NNP cord-015021-pol2qm74 680 2 TO to IN cord-015021-pol2qm74 680 3 MESENTERIC MESENTERIC NNP cord-015021-pol2qm74 680 4 NODES node NNS cord-015021-pol2qm74 680 5 -71 -71 VBG cord-015021-pol2qm74 680 6 , , , cord-015021-pol2qm74 680 7 90 90 CD cord-015021-pol2qm74 680 8 , , , cord-015021-pol2qm74 680 9 and and CC cord-015021-pol2qm74 680 10 30 30 CD cord-015021-pol2qm74 680 11 percent percent NN cord-015021-pol2qm74 680 12 at at IN cord-015021-pol2qm74 680 13 24 24 CD cord-015021-pol2qm74 680 14 , , , cord-015021-pol2qm74 680 15 48 48 CD cord-015021-pol2qm74 680 16 , , , cord-015021-pol2qm74 680 17 and and CC cord-015021-pol2qm74 680 18 9fi 9fi CD cord-015021-pol2qm74 680 19 hours hour NNS cord-015021-pol2qm74 680 20 compared compare VBN cord-015021-pol2qm74 680 21 to to IN cord-015021-pol2qm74 680 22 49b 49b CD cord-015021-pol2qm74 680 23 in in IN cord-015021-pol2qm74 680 24 sham sham NN cord-015021-pol2qm74 680 25 controls control NNS cord-015021-pol2qm74 680 26 ( ( -LRB- cord-015021-pol2qm74 680 27 n n NN cord-015021-pol2qm74 680 28 = = SYM cord-015021-pol2qm74 680 29 l l NN cord-015021-pol2qm74 680 30 of of IN cord-015021-pol2qm74 680 31 26 26 CD cord-015021-pol2qm74 680 32 ) ) -RRB- cord-015021-pol2qm74 680 33 . . . cord-015021-pol2qm74 681 1 CONCLUSION conclusion JJ cord-015021-pol2qm74 681 2 -Bacterial -bacterial JJ cord-015021-pol2qm74 681 3 translocation translocation NN cord-015021-pol2qm74 681 4 following follow VBG cord-015021-pol2qm74 681 5 panetoatieobiliary panetoatieobiliary NN cord-015021-pol2qm74 681 6 duct duct NN cord-015021-pol2qm74 681 7 lJgation lJgation NNP cord-015021-pol2qm74 681 8 induced induce VBN cord-015021-pol2qm74 681 9 panereatitls panereatitls NNP cord-015021-pol2qm74 681 10 ha ha UH cord-015021-pol2qm74 681 11 the the DT cord-015021-pol2qm74 681 12 rat rat NN cord-015021-pol2qm74 681 13 is be VBZ cord-015021-pol2qm74 681 14 tighlly tighlly RB cord-015021-pol2qm74 681 15 linked link VBN cord-015021-pol2qm74 681 16 to to IN cord-015021-pol2qm74 681 17 intestinal intestinal JJ cord-015021-pol2qm74 681 18 trausit trausit NN cord-015021-pol2qm74 681 19 and and CC cord-015021-pol2qm74 681 20 bacterial bacterial JJ cord-015021-pol2qm74 681 21 overgrowth overgrowth NN cord-015021-pol2qm74 681 22 within within IN cord-015021-pol2qm74 681 23 the the DT cord-015021-pol2qm74 681 24 gut gut NN cord-015021-pol2qm74 681 25 lumen lumen NN cord-015021-pol2qm74 681 26 . . . cord-015021-pol2qm74 682 1 SPECLrJLATION speclrjlation CD cord-015021-pol2qm74 683 1 -The -the WDT cord-015021-pol2qm74 683 2 ilens ilen NNS cord-015021-pol2qm74 683 3 in in IN cord-015021-pol2qm74 683 4 in/~aRm in/~aRm NNP cord-015021-pol2qm74 684 1 ~ation ~ation NNP cord-015021-pol2qm74 684 2 may may MD cord-015021-pol2qm74 684 3 be be VB cord-015021-pol2qm74 684 4 related relate VBN cord-015021-pol2qm74 684 5 to to IN cord-015021-pol2qm74 684 6 activation activation NN cord-015021-pol2qm74 684 7 of of IN cord-015021-pol2qm74 684 8 eytokiaes eytokiae NNS cord-015021-pol2qm74 684 9 and and CC cord-015021-pol2qm74 684 10 mediated mediate VBN cord-015021-pol2qm74 684 11 by by IN cord-015021-pol2qm74 684 12 nitric nitric NN cord-015021-pol2qm74 684 13 oxide oxide NN cord-015021-pol2qm74 684 14 . . . cord-015021-pol2qm74 685 1 Preliminary preliminary JJ cord-015021-pol2qm74 685 2 evidence evidence NN cord-015021-pol2qm74 685 3 for for IN cord-015021-pol2qm74 685 4 this this DT cord-015021-pol2qm74 685 5 notion notion NN cord-015021-pol2qm74 685 6 will will MD cord-015021-pol2qm74 685 7 be be VB cord-015021-pol2qm74 685 8 discussed discuss VBN cord-015021-pol2qm74 685 9 . . . cord-015021-pol2qm74 686 1 In in IN cord-015021-pol2qm74 686 2 a a DT cord-015021-pol2qm74 686 3 series series NN cord-015021-pol2qm74 686 4 of of IN cord-015021-pol2qm74 686 5 studies study NNS cord-015021-pol2qm74 686 6 we -PRON- PRP cord-015021-pol2qm74 686 7 investigated investigate VBD cord-015021-pol2qm74 686 8 : : : cord-015021-pol2qm74 686 9 a a LS cord-015021-pol2qm74 686 10 ) ) -RRB- cord-015021-pol2qm74 686 11 the the DT cord-015021-pol2qm74 686 12 time time NN cord-015021-pol2qm74 686 13 course course NN cord-015021-pol2qm74 686 14 of of IN cord-015021-pol2qm74 686 15 bacterial bacterial JJ cord-015021-pol2qm74 686 16 translocation translocation NN cord-015021-pol2qm74 686 17 ( ( -LRB- cord-015021-pol2qm74 686 18 BT BT NNP cord-015021-pol2qm74 686 19 ) ) -RRB- cord-015021-pol2qm74 686 20 , , , cord-015021-pol2qm74 686 21 b b LS cord-015021-pol2qm74 686 22 ) ) -RRB- cord-015021-pol2qm74 686 23 the the DT cord-015021-pol2qm74 686 24 kinetics kinetic NNS cord-015021-pol2qm74 686 25 of of IN cord-015021-pol2qm74 686 26 LPS LPS NNP cord-015021-pol2qm74 686 27 and and CC cord-015021-pol2qm74 686 28 cytokine cytokine NN cord-015021-pol2qm74 686 29 appearance appearance NN cord-015021-pol2qm74 686 30 ( ( -LRB- cord-015021-pol2qm74 686 31 TNF TNF NNP cord-015021-pol2qm74 686 32 , , , cord-015021-pol2qm74 686 33 IL-6 IL-6 NNP cord-015021-pol2qm74 686 34 , , , cord-015021-pol2qm74 686 35 Soluble Soluble NNP cord-015021-pol2qm74 686 36 TNF TNF NNP cord-015021-pol2qm74 686 37 receptor receptor NN cord-015021-pol2qm74 686 38 [ [ -LRB- cord-015021-pol2qm74 686 39 sTNF stnf NN cord-015021-pol2qm74 686 40 - - HYPH cord-015021-pol2qm74 686 41 R r NN cord-015021-pol2qm74 686 42 ] ] -RRB- cord-015021-pol2qm74 686 43 ) ) -RRB- cord-015021-pol2qm74 686 44 in in IN cord-015021-pol2qm74 686 45 the the DT cord-015021-pol2qm74 686 46 circulation circulation NN cord-015021-pol2qm74 686 47 , , , cord-015021-pol2qm74 686 48 and and CC cord-015021-pol2qm74 686 49 c c LS cord-015021-pol2qm74 686 50 ) ) -RRB- cord-015021-pol2qm74 686 51 the the DT cord-015021-pol2qm74 686 52 role role NN cord-015021-pol2qm74 686 53 of of IN cord-015021-pol2qm74 686 54 LPS LPS NNP cord-015021-pol2qm74 686 55 and/or and/or CC cord-015021-pol2qm74 686 56 TNF TNF NNP cord-015021-pol2qm74 686 57 with with IN cord-015021-pol2qm74 686 58 regard regard NN cord-015021-pol2qm74 686 59 to to IN cord-015021-pol2qm74 686 60 haemorrhagic haemorrhagic JJ cord-015021-pol2qm74 686 61 shock shock NN cord-015021-pol2qm74 686 62 ( ( -LRB- cord-015021-pol2qm74 686 63 HS HS NNP cord-015021-pol2qm74 686 64 ) ) -RRB- cord-015021-pol2qm74 686 65 related relate VBN cord-015021-pol2qm74 686 66 pathophysiologie pathophysiologie NN cord-015021-pol2qm74 686 67 alterations alteration NNS cord-015021-pol2qm74 686 68 and and CC cord-015021-pol2qm74 686 69 mortality mortality NN cord-015021-pol2qm74 686 70 in in IN cord-015021-pol2qm74 686 71 baboons baboon NNS cord-015021-pol2qm74 686 72 and/or and/or CC cord-015021-pol2qm74 686 73 rats rat NNS cord-015021-pol2qm74 686 74 . . . cord-015021-pol2qm74 687 1 Method method NN cord-015021-pol2qm74 687 2 : : : cord-015021-pol2qm74 688 1 Baboons baboon NNS cord-015021-pol2qm74 688 2 were be VBD cord-015021-pol2qm74 688 3 subjected subject VBN cord-015021-pol2qm74 688 4 to to IN cord-015021-pol2qm74 688 5 femur femur NN cord-015021-pol2qm74 688 6 fracture fracture NN cord-015021-pol2qm74 688 7 , , , cord-015021-pol2qm74 688 8 soft soft JJ cord-015021-pol2qm74 688 9 tissue tissue NN cord-015021-pol2qm74 688 10 trauma trauma NN cord-015021-pol2qm74 688 11 ( ( -LRB- cord-015021-pol2qm74 688 12 acute acute JJ cord-015021-pol2qm74 688 13 experiment experiment NN cord-015021-pol2qm74 688 14 ) ) -RRB- cord-015021-pol2qm74 688 15 , , , cord-015021-pol2qm74 688 16 and and CC cord-015021-pol2qm74 688 17 HS HS NNP cord-015021-pol2qm74 688 18 ( ( -LRB- cord-015021-pol2qm74 688 19 40 40 CD cord-015021-pol2qm74 688 20 mmHg mmHg NNS cord-015021-pol2qm74 688 21 mean mean VBP cord-015021-pol2qm74 688 22 arterial arterial JJ cord-015021-pol2qm74 688 23 pressure pressure NN cord-015021-pol2qm74 688 24 : : : cord-015021-pol2qm74 688 25 MAP map VB cord-015021-pol2qm74 688 26 for for IN cord-015021-pol2qm74 688 27 2 2 CD cord-015021-pol2qm74 688 28 - - SYM cord-015021-pol2qm74 688 29 4 4 CD cord-015021-pol2qm74 688 30 h h NN cord-015021-pol2qm74 688 31 terminated terminate VBD cord-015021-pol2qm74 688 32 at at IN cord-015021-pol2qm74 688 33 an an DT cord-015021-pol2qm74 688 34 accumulated accumulate VBN cord-015021-pol2qm74 688 35 oxygen oxygen NN cord-015021-pol2qm74 688 36 debt debt NN cord-015021-pol2qm74 688 37 of of IN cord-015021-pol2qm74 688 38 180 180 CD cord-015021-pol2qm74 688 39 - - SYM cord-015021-pol2qm74 688 40 200 200 CD cord-015021-pol2qm74 688 41 ml ml NNS cord-015021-pol2qm74 688 42 / / SYM cord-015021-pol2qm74 688 43 kg kg NNS cord-015021-pol2qm74 688 44 followed follow VBN cord-015021-pol2qm74 688 45 by by IN cord-015021-pol2qm74 688 46 resuscitation resuscitation NN cord-015021-pol2qm74 688 47 ) ) -RRB- cord-015021-pol2qm74 688 48 . . . cord-015021-pol2qm74 689 1 A a DT cord-015021-pol2qm74 689 2 chronic chronic JJ cord-015021-pol2qm74 689 3 model model NN cord-015021-pol2qm74 689 4 of of IN cord-015021-pol2qm74 689 5 HS HS NNP cord-015021-pol2qm74 689 6 was be VBD cord-015021-pol2qm74 689 7 set set VBN cord-015021-pol2qm74 689 8 up up RP cord-015021-pol2qm74 689 9 by by IN cord-015021-pol2qm74 689 10 administration administration NN cord-015021-pol2qm74 689 11 of of IN cord-015021-pol2qm74 689 12 zymosan zymosan NNP cord-015021-pol2qm74 689 13 activated activated NNP cord-015021-pol2qm74 689 14 plasma plasma NN cord-015021-pol2qm74 689 15 ( ( -LRB- cord-015021-pol2qm74 689 16 ZAP ZAP NNP cord-015021-pol2qm74 689 17 ) ) -RRB- cord-015021-pol2qm74 689 18 before before IN cord-015021-pol2qm74 689 19 and and CC cord-015021-pol2qm74 689 20 after after IN cord-015021-pol2qm74 689 21 HS HS NNP cord-015021-pol2qm74 689 22 but but CC cord-015021-pol2qm74 689 23 without without IN cord-015021-pol2qm74 689 24 trauma trauma NN cord-015021-pol2qm74 689 25 . . . cord-015021-pol2qm74 690 1 HS HS NNP cord-015021-pol2qm74 690 2 was be VBD cord-015021-pol2qm74 690 3 induced induce VBN cord-015021-pol2qm74 690 4 in in IN cord-015021-pol2qm74 690 5 rats rat NNS cord-015021-pol2qm74 690 6 by by IN cord-015021-pol2qm74 690 7 bleeding bleed VBG cord-015021-pol2qm74 690 8 the the DT cord-015021-pol2qm74 690 9 animals animal NNS cord-015021-pol2qm74 690 10 to to IN cord-015021-pol2qm74 690 11 MAP MAP NNP cord-015021-pol2qm74 690 12 of of IN cord-015021-pol2qm74 690 13 30 30 CD cord-015021-pol2qm74 690 14 - - SYM cord-015021-pol2qm74 690 15 35 35 CD cord-015021-pol2qm74 690 16 mmHg mmHg NNS cord-015021-pol2qm74 690 17 90 90 CD cord-015021-pol2qm74 690 18 - - SYM cord-015021-pol2qm74 690 19 180 180 CD cord-015021-pol2qm74 690 20 rain rain NN cord-015021-pol2qm74 690 21 followed follow VBN cord-015021-pol2qm74 690 22 by by IN cord-015021-pol2qm74 690 23 resuscitation resuscitation NN cord-015021-pol2qm74 690 24 . . . cord-015021-pol2qm74 691 1 Results result NNS cord-015021-pol2qm74 691 2 and and CC cord-015021-pol2qm74 691 3 conclusion conclusion NN cord-015021-pol2qm74 691 4 : : : cord-015021-pol2qm74 691 5 In in IN cord-015021-pol2qm74 691 6 rats rat NNS cord-015021-pol2qm74 691 7 , , , cord-015021-pol2qm74 691 8 LPS LPS NNP cord-015021-pol2qm74 691 9 increased increase VBD cord-015021-pol2qm74 691 10 in in IN cord-015021-pol2qm74 691 11 the the DT cord-015021-pol2qm74 691 12 systemic systemic JJ cord-015021-pol2qm74 691 13 circulation circulation NN cord-015021-pol2qm74 691 14 , , , cord-015021-pol2qm74 691 15 plasma plasma NN cord-015021-pol2qm74 691 16 TNF TNF NNP cord-015021-pol2qm74 691 17 levels level NNS cord-015021-pol2qm74 691 18 were be VBD cord-015021-pol2qm74 691 19 found find VBN cord-015021-pol2qm74 691 20 to to TO cord-015021-pol2qm74 691 21 be be VB cord-015021-pol2qm74 691 22 significantly significantly RB cord-015021-pol2qm74 691 23 elevated elevate VBN cord-015021-pol2qm74 691 24 at at IN cord-015021-pol2qm74 691 25 90 90 CD cord-015021-pol2qm74 691 26 min min NN cord-015021-pol2qm74 691 27 and and CC cord-015021-pol2qm74 691 28 were be VBD cord-015021-pol2qm74 691 29 still still RB cord-015021-pol2qm74 691 30 markedly markedly RB cord-015021-pol2qm74 691 31 increased increase VBN cord-015021-pol2qm74 691 32 at at IN cord-015021-pol2qm74 691 33 150 150 CD cord-015021-pol2qm74 691 34 rain rain NN cord-015021-pol2qm74 691 35 postshock postshock NN cord-015021-pol2qm74 691 36 . . . cord-015021-pol2qm74 692 1 Plasma Plasma NNP cord-015021-pol2qm74 692 2 TNF TNF NNP cord-015021-pol2qm74 692 3 , , , cord-015021-pol2qm74 692 4 IL-6 IL-6 NNP cord-015021-pol2qm74 692 5 , , , cord-015021-pol2qm74 692 6 and and CC cord-015021-pol2qm74 692 7 sTNF stnf NN cord-015021-pol2qm74 692 8 - - HYPH cord-015021-pol2qm74 692 9 R r NN cord-015021-pol2qm74 692 10 levels level NNS cord-015021-pol2qm74 692 11 increased increase VBD cord-015021-pol2qm74 692 12 already already RB cord-015021-pol2qm74 692 13 during during IN cord-015021-pol2qm74 692 14 the the DT cord-015021-pol2qm74 692 15 shock shock NN cord-015021-pol2qm74 692 16 period period NN cord-015021-pol2qm74 692 17 in in IN cord-015021-pol2qm74 692 18 baboons baboon NNS cord-015021-pol2qm74 692 19 , , , cord-015021-pol2qm74 692 20 while while IN cord-015021-pol2qm74 692 21 TNF TNF NNP cord-015021-pol2qm74 692 22 was be VBD cord-015021-pol2qm74 692 23 not not RB cord-015021-pol2qm74 692 24 detectable detectable JJ cord-015021-pol2qm74 692 25 . . . cord-015021-pol2qm74 693 1 Our -PRON- PRP$ cord-015021-pol2qm74 693 2 data datum NNS cord-015021-pol2qm74 693 3 suggest suggest VBP cord-015021-pol2qm74 693 4 that that IN cord-015021-pol2qm74 693 5 haemorrhagic haemorrhagic JJ cord-015021-pol2qm74 693 6 shock shock NN cord-015021-pol2qm74 693 7 may may MD cord-015021-pol2qm74 693 8 lead lead VB cord-015021-pol2qm74 693 9 to to IN cord-015021-pol2qm74 693 10 early early JJ cord-015021-pol2qm74 693 11 BT BT NNP cord-015021-pol2qm74 693 12 in in IN cord-015021-pol2qm74 693 13 the the DT cord-015021-pol2qm74 693 14 intestinal intestinal JJ cord-015021-pol2qm74 693 15 wall wall NN cord-015021-pol2qm74 693 16 ( ( -LRB- cord-015021-pol2qm74 693 17 at at IN cord-015021-pol2qm74 693 18 30 30 CD cord-015021-pol2qm74 693 19 min min NN cord-015021-pol2qm74 693 20 following follow VBG cord-015021-pol2qm74 693 21 resuscitation resuscitation NN cord-015021-pol2qm74 693 22 in in IN cord-015021-pol2qm74 693 23 rats rat NNS cord-015021-pol2qm74 693 24 subjected subject VBN cord-015021-pol2qm74 693 25 to to IN cord-015021-pol2qm74 693 26 HS HS NNP cord-015021-pol2qm74 693 27 for for IN cord-015021-pol2qm74 693 28 90 90 CD cord-015021-pol2qm74 693 29 min min NN cord-015021-pol2qm74 693 30 , , , cord-015021-pol2qm74 693 31 similarly similarly RB cord-015021-pol2qm74 693 32 at at IN cord-015021-pol2qm74 693 33 3 3 CD cord-015021-pol2qm74 693 34 h h NN cord-015021-pol2qm74 693 35 after after IN cord-015021-pol2qm74 693 36 the the DT cord-015021-pol2qm74 693 37 end end NN cord-015021-pol2qm74 693 38 of of IN cord-015021-pol2qm74 693 39 oxygen oxygen NN cord-015021-pol2qm74 693 40 debt debt NN cord-015021-pol2qm74 693 41 period period NN cord-015021-pol2qm74 693 42 in in IN cord-015021-pol2qm74 693 43 baboons baboon NNS cord-015021-pol2qm74 693 44 ) ) -RRB- cord-015021-pol2qm74 693 45 and and CC cord-015021-pol2qm74 693 46 transient transient JJ cord-015021-pol2qm74 693 47 access access NN cord-015021-pol2qm74 693 48 of of IN cord-015021-pol2qm74 693 49 gut gut NN cord-015021-pol2qm74 693 50 - - HYPH cord-015021-pol2qm74 693 51 derived derive VBN cord-015021-pol2qm74 693 52 LPS LPS NNP cord-015021-pol2qm74 693 53 into into IN cord-015021-pol2qm74 693 54 the the DT cord-015021-pol2qm74 693 55 circulation circulation NN cord-015021-pol2qm74 693 56 ( ( -LRB- cord-015021-pol2qm74 693 57 levels level NNS cord-015021-pol2qm74 693 58 became become VBD cord-015021-pol2qm74 693 59 significant significant JJ cord-015021-pol2qm74 693 60 at at IN cord-015021-pol2qm74 693 61 120 120 CD cord-015021-pol2qm74 693 62 min min NN cord-015021-pol2qm74 693 63 , , , cord-015021-pol2qm74 693 64 while while IN cord-015021-pol2qm74 693 65 in in IN cord-015021-pol2qm74 693 66 baboons baboon NNS cord-015021-pol2qm74 693 67 higher high JJR cord-015021-pol2qm74 693 68 levels level NNS cord-015021-pol2qm74 693 69 up up IN cord-015021-pol2qm74 693 70 to to IN cord-015021-pol2qm74 693 71 300 300 CD cord-015021-pol2qm74 693 72 pg pg NN cord-015021-pol2qm74 693 73 / / SYM cord-015021-pol2qm74 693 74 ml ml NNS cord-015021-pol2qm74 693 75 were be VBD cord-015021-pol2qm74 693 76 found find VBN cord-015021-pol2qm74 693 77 at at IN cord-015021-pol2qm74 693 78 the the DT cord-015021-pol2qm74 693 79 end end NN cord-015021-pol2qm74 693 80 of of IN cord-015021-pol2qm74 693 81 shock shock NN cord-015021-pol2qm74 693 82 and and CC cord-015021-pol2qm74 693 83 1 1 CD cord-015021-pol2qm74 693 84 h h NN cord-015021-pol2qm74 693 85 after after IN cord-015021-pol2qm74 693 86 reinfusion reinfusion NN cord-015021-pol2qm74 693 87 , , , cord-015021-pol2qm74 693 88 partially partially RB cord-015021-pol2qm74 693 89 accompanied accompany VBN cord-015021-pol2qm74 693 90 by by IN cord-015021-pol2qm74 693 91 bacteremia bacteremia NN cord-015021-pol2qm74 693 92 ) ) -RRB- cord-015021-pol2qm74 693 93 . . . cord-015021-pol2qm74 694 1 In in IN cord-015021-pol2qm74 694 2 addition addition NN cord-015021-pol2qm74 694 3 , , , cord-015021-pol2qm74 694 4 since since IN cord-015021-pol2qm74 694 5 the the DT cord-015021-pol2qm74 694 6 treatment treatment NN cord-015021-pol2qm74 694 7 of of IN cord-015021-pol2qm74 694 8 rats rat NNS cord-015021-pol2qm74 694 9 with with IN cord-015021-pol2qm74 694 10 anti anti JJ cord-015021-pol2qm74 694 11 LPS LPS NNP cord-015021-pol2qm74 694 12 measures measure NNS cord-015021-pol2qm74 694 13 or or CC cord-015021-pol2qm74 694 14 anti anti NNP cord-015021-pol2qm74 694 15 TNF TNF NNP cord-015021-pol2qm74 694 16 therapy therapy NN cord-015021-pol2qm74 694 17 significantly significantly RB cord-015021-pol2qm74 694 18 improved improve VBD cord-015021-pol2qm74 694 19 the the DT cord-015021-pol2qm74 694 20 48-hour 48-hour JJ cord-015021-pol2qm74 694 21 survival survival NN cord-015021-pol2qm74 694 22 rate rate NN cord-015021-pol2qm74 694 23 it -PRON- PRP cord-015021-pol2qm74 694 24 can can MD cord-015021-pol2qm74 694 25 be be VB cord-015021-pol2qm74 694 26 assumed assume VBN cord-015021-pol2qm74 694 27 that that IN cord-015021-pol2qm74 694 28 endogenous endogenous JJ cord-015021-pol2qm74 694 29 LPS LPS NNP cord-015021-pol2qm74 694 30 and and CC cord-015021-pol2qm74 694 31 LPS LPS NNP cord-015021-pol2qm74 694 32 - - HYPH cord-015021-pol2qm74 694 33 induced induce VBN cord-015021-pol2qm74 694 34 mediator(s mediator(s NNP cord-015021-pol2qm74 694 35 ) ) -RRB- cord-015021-pol2qm74 694 36 , , , cord-015021-pol2qm74 694 37 in in IN cord-015021-pol2qm74 694 38 particular particular JJ cord-015021-pol2qm74 694 39 TNF TNF NNP cord-015021-pol2qm74 694 40 , , , cord-015021-pol2qm74 694 41 may may MD cord-015021-pol2qm74 694 42 lead lead VB cord-015021-pol2qm74 694 43 to to IN cord-015021-pol2qm74 694 44 organ organ NN cord-015021-pol2qm74 694 45 injury injury NN cord-015021-pol2qm74 694 46 and and CC cord-015021-pol2qm74 694 47 mortality mortality NN cord-015021-pol2qm74 694 48 following follow VBG cord-015021-pol2qm74 694 49 haemorrhagic haemorrhagic JJ cord-015021-pol2qm74 694 50 shock shock NN cord-015021-pol2qm74 694 51 . . . cord-015021-pol2qm74 695 1 Alteration alteration NN cord-015021-pol2qm74 695 2 of of IN cord-015021-pol2qm74 695 3 the the DT cord-015021-pol2qm74 695 4 mesenteric mesenteric JJ cord-015021-pol2qm74 695 5 blood blood NN cord-015021-pol2qm74 695 6 flow flow NN cord-015021-pol2qm74 695 7 and and CC cord-015021-pol2qm74 695 8 the the DT cord-015021-pol2qm74 695 9 consequent consequent JJ cord-015021-pol2qm74 695 10 ischemia ischemia NN cord-015021-pol2qm74 695 11 / / SYM cord-015021-pol2qm74 695 12 reperfusion reperfusion NN cord-015021-pol2qm74 695 13 injury injury NN cord-015021-pol2qm74 695 14 to to IN cord-015021-pol2qm74 695 15 the the DT cord-015021-pol2qm74 695 16 intestine intestine NN cord-015021-pol2qm74 695 17 appear appear VB cord-015021-pol2qm74 695 18 to to TO cord-015021-pol2qm74 695 19 be be VB cord-015021-pol2qm74 695 20 one one CD cord-015021-pol2qm74 695 21 of of IN cord-015021-pol2qm74 695 22 the the DT cord-015021-pol2qm74 695 23 earliest early JJS cord-015021-pol2qm74 695 24 events event NNS cord-015021-pol2qm74 695 25 in in IN cord-015021-pol2qm74 695 26 the the DT cord-015021-pol2qm74 695 27 systemic systemic JJ cord-015021-pol2qm74 695 28 inflammatory inflammatory JJ cord-015021-pol2qm74 695 29 response response NN cord-015021-pol2qm74 695 30 following follow VBG cord-015021-pol2qm74 695 31 severe severe JJ cord-015021-pol2qm74 695 32 thermal thermal JJ cord-015021-pol2qm74 695 33 injuries injury NNS cord-015021-pol2qm74 695 34 . . . cord-015021-pol2qm74 696 1 The the DT cord-015021-pol2qm74 696 2 causative causative JJ cord-015021-pol2qm74 696 3 relationship relationship NN cord-015021-pol2qm74 696 4 between between IN cord-015021-pol2qm74 696 5 the the DT cord-015021-pol2qm74 696 6 subsequent subsequent JJ cord-015021-pol2qm74 696 7 disruption disruption NN cord-015021-pol2qm74 696 8 of of IN cord-015021-pol2qm74 696 9 the the DT cord-015021-pol2qm74 696 10 intestinal intestinal JJ cord-015021-pol2qm74 696 11 integrity integrity NN cord-015021-pol2qm74 696 12 and and CC cord-015021-pol2qm74 696 13 the the DT cord-015021-pol2qm74 696 14 potentiation potentiation NN cord-015021-pol2qm74 696 15 of of IN cord-015021-pol2qm74 696 16 the the DT cord-015021-pol2qm74 696 17 translocation translocation NN cord-015021-pol2qm74 696 18 of of IN cord-015021-pol2qm74 696 19 indigenous indigenous JJ cord-015021-pol2qm74 696 20 bacteria bacteria NNS cord-015021-pol2qm74 696 21 and/or and/or CC cord-015021-pol2qm74 696 22 endotoxins endotoxin NNS cord-015021-pol2qm74 696 23 to to IN cord-015021-pol2qm74 696 24 remote remote JJ cord-015021-pol2qm74 696 25 body body NN cord-015021-pol2qm74 696 26 organs organ NNS cord-015021-pol2qm74 696 27 and and CC cord-015021-pol2qm74 696 28 the the DT cord-015021-pol2qm74 696 29 systemic systemic JJ cord-015021-pol2qm74 696 30 circulation circulation NN cord-015021-pol2qm74 696 31 has have VBZ cord-015021-pol2qm74 696 32 been be VBN cord-015021-pol2qm74 696 33 deeumented deeumente VBN cord-015021-pol2qm74 696 34 in in IN cord-015021-pol2qm74 696 35 several several JJ cord-015021-pol2qm74 696 36 studies study NNS cord-015021-pol2qm74 696 37 . . . cord-015021-pol2qm74 697 1 Among among IN cord-015021-pol2qm74 697 2 other other JJ cord-015021-pol2qm74 697 3 effects effect NNS cord-015021-pol2qm74 697 4 , , , cord-015021-pol2qm74 697 5 endotoxemia endotoxemia NN cord-015021-pol2qm74 697 6 solely solely RB cord-015021-pol2qm74 697 7 or or CC cord-015021-pol2qm74 697 8 acting act VBG cord-015021-pol2qm74 697 9 synergistically synergistically RB cord-015021-pol2qm74 697 10 with with IN cord-015021-pol2qm74 697 11 thermal thermal JJ cord-015021-pol2qm74 697 12 injuries injury NNS cord-015021-pol2qm74 697 13 has have VBZ cord-015021-pol2qm74 697 14 been be VBN cord-015021-pol2qm74 697 15 shown show VBN cord-015021-pol2qm74 697 16 to to TO cord-015021-pol2qm74 697 17 promote promote VB cord-015021-pol2qm74 697 18 bacterial bacterial JJ cord-015021-pol2qm74 697 19 translocation translocation NN cord-015021-pol2qm74 697 20 . . . cord-015021-pol2qm74 698 1 As as IN cord-015021-pol2qm74 698 2 these these DT cord-015021-pol2qm74 698 3 sequences sequence NNS cord-015021-pol2qm74 698 4 continue continue VBP cord-015021-pol2qm74 698 5 without without IN cord-015021-pol2qm74 698 6 adequate adequate JJ cord-015021-pol2qm74 698 7 intervention intervention NN cord-015021-pol2qm74 698 8 , , , cord-015021-pol2qm74 698 9 multiple multiple JJ cord-015021-pol2qm74 698 10 organ organ NN cord-015021-pol2qm74 698 11 failure failure NN cord-015021-pol2qm74 698 12 and and CC cord-015021-pol2qm74 698 13 eventually eventually RB cord-015021-pol2qm74 698 14 death death NN cord-015021-pol2qm74 698 15 may may MD cord-015021-pol2qm74 698 16 become become VB cord-015021-pol2qm74 698 17 inevitable inevitable JJ cord-015021-pol2qm74 698 18 . . . cord-015021-pol2qm74 699 1 Hence hence RB cord-015021-pol2qm74 699 2 , , , cord-015021-pol2qm74 699 3 the the DT cord-015021-pol2qm74 699 4 crucial crucial JJ cord-015021-pol2qm74 699 5 need need NN cord-015021-pol2qm74 699 6 of of IN cord-015021-pol2qm74 699 7 treatment treatment NN cord-015021-pol2qm74 699 8 modalities modality NNS cord-015021-pol2qm74 699 9 with with IN cord-015021-pol2qm74 699 10 the the DT cord-015021-pol2qm74 699 11 capacity capacity NN cord-015021-pol2qm74 699 12 of of IN cord-015021-pol2qm74 699 13 modulating modulate VBG cord-015021-pol2qm74 699 14 the the DT cord-015021-pol2qm74 699 15 intestinal intestinal JJ cord-015021-pol2qm74 699 16 blood blood NN cord-015021-pol2qm74 699 17 flow flow NN cord-015021-pol2qm74 699 18 and and CC cord-015021-pol2qm74 699 19 preventing prevent VBG cord-015021-pol2qm74 699 20 the the DT cord-015021-pol2qm74 699 21 manifestations manifestation NNS cord-015021-pol2qm74 699 22 of of IN cord-015021-pol2qm74 699 23 these these DT cord-015021-pol2qm74 699 24 pathological pathological JJ cord-015021-pol2qm74 699 25 incidents incident NNS cord-015021-pol2qm74 699 26 . . . cord-015021-pol2qm74 700 1 Although although IN cord-015021-pol2qm74 700 2 the the DT cord-015021-pol2qm74 700 3 underlying underlie VBG cord-015021-pol2qm74 700 4 mechanisms mechanism NNS cord-015021-pol2qm74 700 5 of of IN cord-015021-pol2qm74 700 6 this this DT cord-015021-pol2qm74 700 7 process process NN cord-015021-pol2qm74 700 8 have have VBP cord-015021-pol2qm74 700 9 not not RB cord-015021-pol2qm74 700 10 yet yet RB cord-015021-pol2qm74 700 11 been be VBN cord-015021-pol2qm74 700 12 fully fully RB cord-015021-pol2qm74 700 13 elucidated elucidate VBN cord-015021-pol2qm74 700 14 , , , cord-015021-pol2qm74 700 15 there there EX cord-015021-pol2qm74 700 16 is be VBZ cord-015021-pol2qm74 700 17 accumulating accumulate VBG cord-015021-pol2qm74 700 18 evidence evidence NN cord-015021-pol2qm74 700 19 that that IN cord-015021-pol2qm74 700 20 various various JJ cord-015021-pol2qm74 700 21 interacting interact VBG cord-015021-pol2qm74 700 22 vasomediators vasomediator NNS cord-015021-pol2qm74 700 23 are be VBP cord-015021-pol2qm74 700 24 involved involve VBN cord-015021-pol2qm74 700 25 . . . cord-015021-pol2qm74 701 1 The the DT cord-015021-pol2qm74 701 2 actions action NNS cord-015021-pol2qm74 701 3 of of IN cord-015021-pol2qm74 701 4 these these DT cord-015021-pol2qm74 701 5 mediators mediator NNS cord-015021-pol2qm74 701 6 can can MD cord-015021-pol2qm74 701 7 probably probably RB cord-015021-pol2qm74 701 8 be be VB cord-015021-pol2qm74 701 9 modulated modulate VBN cord-015021-pol2qm74 701 10 by by IN cord-015021-pol2qm74 701 11 either either DT cord-015021-pol2qm74 701 12 nonspecific nonspecific JJ cord-015021-pol2qm74 701 13 or or CC cord-015021-pol2qm74 701 14 selective selective JJ cord-015021-pol2qm74 701 15 agents agent NNS cord-015021-pol2qm74 701 16 . . . cord-015021-pol2qm74 702 1 Among among IN cord-015021-pol2qm74 702 2 the the DT cord-015021-pol2qm74 702 3 nonspecific nonspecific JJ cord-015021-pol2qm74 702 4 agents agent NNS cord-015021-pol2qm74 702 5 , , , cord-015021-pol2qm74 702 6 the the DT cord-015021-pol2qm74 702 7 composition composition NN cord-015021-pol2qm74 702 8 , , , cord-015021-pol2qm74 702 9 volume volume NN cord-015021-pol2qm74 702 10 and and CC cord-015021-pol2qm74 702 11 timing timing NN cord-015021-pol2qm74 702 12 of of IN cord-015021-pol2qm74 702 13 the the DT cord-015021-pol2qm74 702 14 resuscitation resuscitation NN cord-015021-pol2qm74 702 15 fluids fluid NNS cord-015021-pol2qm74 702 16 appear appear VBP cord-015021-pol2qm74 702 17 to to TO cord-015021-pol2qm74 702 18 play play VB cord-015021-pol2qm74 702 19 an an DT cord-015021-pol2qm74 702 20 important important JJ cord-015021-pol2qm74 702 21 role role NN cord-015021-pol2qm74 702 22 in in IN cord-015021-pol2qm74 702 23 this this DT cord-015021-pol2qm74 702 24 process process NN cord-015021-pol2qm74 702 25 . . . cord-015021-pol2qm74 703 1 Nitropmsside Nitropmsside NNP cord-015021-pol2qm74 703 2 , , , cord-015021-pol2qm74 703 3 a a DT cord-015021-pol2qm74 703 4 nonspecific nonspecific JJ cord-015021-pol2qm74 703 5 vasodilator vasodilator NN cord-015021-pol2qm74 703 6 , , , cord-015021-pol2qm74 703 7 has have VBZ cord-015021-pol2qm74 703 8 been be VBN cord-015021-pol2qm74 703 9 shown show VBN cord-015021-pol2qm74 703 10 to to TO cord-015021-pol2qm74 703 11 prevent prevent VB cord-015021-pol2qm74 703 12 the the DT cord-015021-pol2qm74 703 13 decrease decrease NN cord-015021-pol2qm74 703 14 of of IN cord-015021-pol2qm74 703 15 the the DT cord-015021-pol2qm74 703 16 postbum postbum JJ cord-015021-pol2qm74 703 17 mesentefic mesentefic NNP cord-015021-pol2qm74 703 18 blood blood NN cord-015021-pol2qm74 703 19 flow flow NN cord-015021-pol2qm74 703 20 when when WRB cord-015021-pol2qm74 703 21 selectively selectively RB cord-015021-pol2qm74 703 22 infused infuse VBN cord-015021-pol2qm74 703 23 in in IN cord-015021-pol2qm74 703 24 the the DT cord-015021-pol2qm74 703 25 mesenteric mesenteric JJ cord-015021-pol2qm74 703 26 artery artery NN cord-015021-pol2qm74 703 27 . . . cord-015021-pol2qm74 704 1 The the DT cord-015021-pol2qm74 704 2 nonspecificity nonspecificity NN cord-015021-pol2qm74 704 3 of of IN cord-015021-pol2qm74 704 4 various various JJ cord-015021-pol2qm74 704 5 vasodialators vasodialator NNS cord-015021-pol2qm74 704 6 with with IN cord-015021-pol2qm74 704 7 their -PRON- PRP$ cord-015021-pol2qm74 704 8 possible possible JJ cord-015021-pol2qm74 704 9 undesirable undesirable JJ cord-015021-pol2qm74 704 10 systemic systemic JJ cord-015021-pol2qm74 704 11 effects effect NNS cord-015021-pol2qm74 704 12 emphasizes emphasize VBZ cord-015021-pol2qm74 704 13 the the DT cord-015021-pol2qm74 704 14 importance importance NN cord-015021-pol2qm74 704 15 of of IN cord-015021-pol2qm74 704 16 the the DT cord-015021-pol2qm74 704 17 identification identification NN cord-015021-pol2qm74 704 18 and and CC cord-015021-pol2qm74 704 19 modulation modulation NN cord-015021-pol2qm74 704 20 of of IN cord-015021-pol2qm74 704 21 selective selective JJ cord-015021-pol2qm74 704 22 vasomNiiators vasomniiator NNS cord-015021-pol2qm74 704 23 . . . cord-015021-pol2qm74 705 1 Thromboxane Thromboxane NNP cord-015021-pol2qm74 705 2 A2 A2 NNP cord-015021-pol2qm74 705 3 ( ( -LRB- cord-015021-pol2qm74 705 4 TxA2 TxA2 NNP cord-015021-pol2qm74 705 5 ) ) -RRB- cord-015021-pol2qm74 705 6 and and CC cord-015021-pol2qm74 705 7 angiotensin angiotensin NN cord-015021-pol2qm74 705 8 II II NNP cord-015021-pol2qm74 705 9 ( ( -LRB- cord-015021-pol2qm74 705 10 A A NNP cord-015021-pol2qm74 705 11 - - HYPH cord-015021-pol2qm74 705 12 II II NNP cord-015021-pol2qm74 705 13 ) ) -RRB- cord-015021-pol2qm74 705 14 appear appear VBP cord-015021-pol2qm74 705 15 to to TO cord-015021-pol2qm74 705 16 be be VB cord-015021-pol2qm74 705 17 the the DT cord-015021-pol2qm74 705 18 primary primary JJ cord-015021-pol2qm74 705 19 mediators mediator NNS cord-015021-pol2qm74 705 20 of of IN cord-015021-pol2qm74 705 21 the the DT cord-015021-pol2qm74 705 22 postburn postburn NN cord-015021-pol2qm74 705 23 vasoconstriction vasoconstriction NN cord-015021-pol2qm74 705 24 . . . cord-015021-pol2qm74 706 1 Both both DT cord-015021-pol2qm74 706 2 mediators mediator NNS cord-015021-pol2qm74 706 3 were be VBD cord-015021-pol2qm74 706 4 found find VBN cord-015021-pol2qm74 706 5 to to TO cord-015021-pol2qm74 706 6 be be VB cord-015021-pol2qm74 706 7 elevated elevate VBN cord-015021-pol2qm74 706 8 following following JJ cord-015021-pol2qm74 706 9 thermal thermal JJ cord-015021-pol2qm74 706 10 injuries injury NNS cord-015021-pol2qm74 706 11 . . . cord-015021-pol2qm74 707 1 In in IN cord-015021-pol2qm74 707 2 a a DT cord-015021-pol2qm74 707 3 previous previous JJ cord-015021-pol2qm74 707 4 study study NN cord-015021-pol2qm74 707 5 , , , cord-015021-pol2qm74 707 6 pretreatment pretreatment NN cord-015021-pol2qm74 707 7 with with IN cord-015021-pol2qm74 707 8 OKY-046 OKY-046 NNP cord-015021-pol2qm74 707 9 , , , cord-015021-pol2qm74 708 1 a a DT cord-015021-pol2qm74 708 2 thromboxane thromboxane NN cord-015021-pol2qm74 708 3 synthetese synthetese NN cord-015021-pol2qm74 708 4 inhibitor inhibitor NN cord-015021-pol2qm74 708 5 was be VBD cord-015021-pol2qm74 708 6 found find VBN cord-015021-pol2qm74 708 7 to to TO cord-015021-pol2qm74 708 8 attenuate attenuate VB cord-015021-pol2qm74 708 9 the the DT cord-015021-pol2qm74 708 10 postbarn postbarn NN cord-015021-pol2qm74 708 11 mesenteric mesenteric JJ cord-015021-pol2qm74 708 12 vasoconstriction vasoconstriction NN cord-015021-pol2qm74 708 13 . . . cord-015021-pol2qm74 709 1 In in IN cord-015021-pol2qm74 709 2 a a DT cord-015021-pol2qm74 709 3 bum bum NN cord-015021-pol2qm74 709 4 / / SYM cord-015021-pol2qm74 709 5 sepsis sepsis NN cord-015021-pol2qm74 709 6 porcine porcine JJ cord-015021-pol2qm74 709 7 model model NN cord-015021-pol2qm74 709 8 the the DT cord-015021-pol2qm74 709 9 efficacy efficacy NN cord-015021-pol2qm74 709 10 of of IN cord-015021-pol2qm74 709 11 DuP753 DuP753 NNP cord-015021-pol2qm74 709 12 , , , cord-015021-pol2qm74 709 13 an an DT cord-015021-pol2qm74 709 14 A-11 A-11 NNP cord-015021-pol2qm74 709 15 receptor receptor NN cord-015021-pol2qm74 709 16 antagonist antagonist NN cord-015021-pol2qm74 709 17 as as IN cord-015021-pol2qm74 709 18 a a DT cord-015021-pol2qm74 709 19 posthum posthum JJ cord-015021-pol2qm74 709 20 treatment treatment NN cord-015021-pol2qm74 709 21 modality modality NN cord-015021-pol2qm74 709 22 was be VBD cord-015021-pol2qm74 709 23 evaluated evaluate VBN cord-015021-pol2qm74 709 24 . . . cord-015021-pol2qm74 710 1 Treatment treatment NN cord-015021-pol2qm74 710 2 with with IN cord-015021-pol2qm74 710 3 DuP753 DuP753 NNS cord-015021-pol2qm74 710 4 prevented prevent VBN cord-015021-pol2qm74 710 5 the the DT cord-015021-pol2qm74 710 6 early early JJ cord-015021-pol2qm74 710 7 posthum posthum NN cord-015021-pol2qm74 710 8 and and CC cord-015021-pol2qm74 710 9 the the DT cord-015021-pol2qm74 710 10 late late JJ cord-015021-pol2qm74 710 11 posteodotoxin posteodotoxin JJ cord-015021-pol2qm74 710 12 elevation elevation NN cord-015021-pol2qm74 710 13 in in IN cord-015021-pol2qm74 710 14 the the DT cord-015021-pol2qm74 710 15 mesenteric mesenteric JJ cord-015021-pol2qm74 710 16 vascular vascular JJ cord-015021-pol2qm74 710 17 resistance resistance NN cord-015021-pol2qm74 710 18 and and CC cord-015021-pol2qm74 710 19 subsequently subsequently RB cord-015021-pol2qm74 710 20 abrogated abrogate VBD cord-015021-pol2qm74 710 21 the the DT cord-015021-pol2qm74 710 22 fall fall NN cord-015021-pol2qm74 710 23 in in IN cord-015021-pol2qm74 710 24 the the DT cord-015021-pol2qm74 710 25 mesenteric mesenteric JJ cord-015021-pol2qm74 710 26 blood blood NN cord-015021-pol2qm74 710 27 flow flow NN cord-015021-pol2qm74 710 28 . . . cord-015021-pol2qm74 711 1 The the DT cord-015021-pol2qm74 711 2 incidence incidence NN cord-015021-pol2qm74 711 3 of of IN cord-015021-pol2qm74 711 4 burn burn NN cord-015021-pol2qm74 711 5 & & CC cord-015021-pol2qm74 711 6 endotoxin endotoxin NN cord-015021-pol2qm74 711 7 induced induce VBN cord-015021-pol2qm74 711 8 bacterial bacterial JJ cord-015021-pol2qm74 711 9 translocation translocation NN cord-015021-pol2qm74 711 10 was be VBD cord-015021-pol2qm74 711 11 significantly significantly RB cord-015021-pol2qm74 711 12 reduced reduce VBN cord-015021-pol2qm74 711 13 by by IN cord-015021-pol2qm74 711 14 DuP753 DuP753 NNS cord-015021-pol2qm74 711 15 from from IN cord-015021-pol2qm74 711 16 86 86 CD cord-015021-pol2qm74 711 17 % % NN cord-015021-pol2qm74 711 18 to to TO cord-015021-pol2qm74 711 19 29 29 CD cord-015021-pol2qm74 711 20 % % NN cord-015021-pol2qm74 711 21 ( ( -LRB- cord-015021-pol2qm74 711 22 P<0.05 P<0.05 NNS cord-015021-pol2qm74 711 23 , , , cord-015021-pol2qm74 711 24 Fisher Fisher NNP cord-015021-pol2qm74 711 25 's 's POS cord-015021-pol2qm74 711 26 exact exact JJ cord-015021-pol2qm74 711 27 test test NN cord-015021-pol2qm74 711 28 ) ) -RRB- cord-015021-pol2qm74 711 29 . . . cord-015021-pol2qm74 712 1 The the DT cord-015021-pol2qm74 712 2 indigenous indigenous JJ cord-015021-pol2qm74 712 3 flora flora NNS cord-015021-pol2qm74 712 4 of of IN cord-015021-pol2qm74 712 5 the the DT cord-015021-pol2qm74 712 6 gastrointestinal gastrointestinal JJ cord-015021-pol2qm74 712 7 tract tract NN cord-015021-pol2qm74 712 8 exerts exert VBZ cord-015021-pol2qm74 712 9 a a DT cord-015021-pol2qm74 712 10 potent potent JJ cord-015021-pol2qm74 712 11 influence influence NN cord-015021-pol2qm74 712 12 on on IN cord-015021-pol2qm74 712 13 the the DT cord-015021-pol2qm74 712 14 developmental developmental JJ cord-015021-pol2qm74 712 15 maturation maturation NN cord-015021-pol2qm74 712 16 of of IN cord-015021-pol2qm74 712 17 normal normal JJ cord-015021-pol2qm74 712 18 systemic systemic JJ cord-015021-pol2qm74 712 19 immunologic immunologic JJ cord-015021-pol2qm74 712 20 responsiveness responsiveness NN cord-015021-pol2qm74 712 21 . . . cord-015021-pol2qm74 713 1 Moreover moreover RB cord-015021-pol2qm74 713 2 , , , cord-015021-pol2qm74 713 3 both both CC cord-015021-pol2qm74 713 4 oral oral JJ cord-015021-pol2qm74 713 5 and and CC cord-015021-pol2qm74 713 6 intraportal intraportal NNP cord-015021-pol2qm74 713 7 administration administration NNP cord-015021-pol2qm74 713 8 of of IN cord-015021-pol2qm74 713 9 experimental experimental JJ cord-015021-pol2qm74 713 10 antigen antigen NN cord-015021-pol2qm74 713 11 is be VBZ cord-015021-pol2qm74 713 12 associated associate VBN cord-015021-pol2qm74 713 13 with with IN cord-015021-pol2qm74 713 14 a a DT cord-015021-pol2qm74 713 15 systemic systemic JJ cord-015021-pol2qm74 713 16 state state NN cord-015021-pol2qm74 713 17 of of IN cord-015021-pol2qm74 713 18 immunologic immunologic JJ cord-015021-pol2qm74 713 19 hyporesponsiveness hyporesponsiveness NN cord-015021-pol2qm74 713 20 , , , cord-015021-pol2qm74 713 21 known know VBN cord-015021-pol2qm74 713 22 as as IN cord-015021-pol2qm74 713 23 oral oral JJ cord-015021-pol2qm74 713 24 tolerance tolerance NN cord-015021-pol2qm74 713 25 . . . cord-015021-pol2qm74 714 1 Since since IN cord-015021-pol2qm74 714 2 trauma trauma NN cord-015021-pol2qm74 714 3 and and CC cord-015021-pol2qm74 714 4 critical critical JJ cord-015021-pol2qm74 714 5 illness illness NN cord-015021-pol2qm74 714 6 are be VBP cord-015021-pol2qm74 714 7 associated associate VBN cord-015021-pol2qm74 714 8 with with IN cord-015021-pol2qm74 714 9 changes change NNS cord-015021-pol2qm74 714 10 in in IN cord-015021-pol2qm74 714 11 the the DT cord-015021-pol2qm74 714 12 flora flora NNS cord-015021-pol2qm74 714 13 of of IN cord-015021-pol2qm74 714 14 the the DT cord-015021-pol2qm74 714 15 gut gut NN cord-015021-pol2qm74 714 16 and and CC cord-015021-pol2qm74 714 17 with with IN cord-015021-pol2qm74 714 18 altered altered JJ cord-015021-pol2qm74 714 19 systemic systemic JJ cord-015021-pol2qm74 714 20 immune immune JJ cord-015021-pol2qm74 714 21 reactivity reactivity NN cord-015021-pol2qm74 714 22 , , , cord-015021-pol2qm74 714 23 we -PRON- PRP cord-015021-pol2qm74 714 24 have have VBP cord-015021-pol2qm74 714 25 hypothesized hypothesize VBN cord-015021-pol2qm74 714 26 that that IN cord-015021-pol2qm74 714 27 the the DT cord-015021-pol2qm74 714 28 interactions interaction NNS cord-015021-pol2qm74 714 29 of of IN cord-015021-pol2qm74 714 30 an an DT cord-015021-pol2qm74 714 31 altered altered JJ cord-015021-pol2qm74 714 32 gut gut NN cord-015021-pol2qm74 714 33 flora flora NNS cord-015021-pol2qm74 714 34 with with IN cord-015021-pol2qm74 714 35 immune immune JJ cord-015021-pol2qm74 714 36 tissues tissue NNS cord-015021-pol2qm74 714 37 in in IN cord-015021-pol2qm74 714 38 the the DT cord-015021-pol2qm74 714 39 gut gut NN cord-015021-pol2qm74 714 40 and and CC cord-015021-pol2qm74 714 41 liver liver NN cord-015021-pol2qm74 714 42 play play VBP cord-015021-pol2qm74 714 43 a a DT cord-015021-pol2qm74 714 44 role role NN cord-015021-pol2qm74 714 45 in in IN cord-015021-pol2qm74 714 46 the the DT cord-015021-pol2qm74 714 47 pathogenesis pathogenesis NN cord-015021-pol2qm74 714 48 of of IN cord-015021-pol2qm74 714 49 the the DT cord-015021-pol2qm74 714 50 immunologic immunologic JJ cord-015021-pol2qm74 714 51 derangements derangement NNS cord-015021-pol2qm74 714 52 of of IN cord-015021-pol2qm74 714 53 critical critical JJ cord-015021-pol2qm74 714 54 illness illness NN cord-015021-pol2qm74 714 55 . . . cord-015021-pol2qm74 715 1 Prolonged prolonged JJ cord-015021-pol2qm74 715 2 feeding feeding NN cord-015021-pol2qm74 715 3 of of IN cord-015021-pol2qm74 715 4 two two CD cord-015021-pol2qm74 715 5 clinically clinically RB cord-015021-pol2qm74 715 6 relevant relevant JJ cord-015021-pol2qm74 715 7 killed kill VBD cord-015021-pol2qm74 715 8 organisms organism NNS cord-015021-pol2qm74 715 9 - - : cord-015021-pol2qm74 715 10 Pseudomonas Pseudomonas NNP cord-015021-pol2qm74 715 11 and and CC cord-015021-pol2qm74 715 12 Candida Candida NNP cord-015021-pol2qm74 715 13 - - : cord-015021-pol2qm74 715 14 to to IN cord-015021-pol2qm74 715 15 a a DT cord-015021-pol2qm74 715 16 rat rat NN cord-015021-pol2qm74 715 17 results result NNS cord-015021-pol2qm74 715 18 in in IN cord-015021-pol2qm74 715 19 significant significant JJ cord-015021-pol2qm74 715 20 impairment impairment NN cord-015021-pol2qm74 715 21 of of IN cord-015021-pol2qm74 715 22 cutaneous cutaneous JJ cord-015021-pol2qm74 715 23 delayed delay VBN cord-015021-pol2qm74 715 24 hypersensitivity hypersensitivity NN cord-015021-pol2qm74 715 25 ( ( -LRB- cord-015021-pol2qm74 715 26 DH DH NNP cord-015021-pol2qm74 715 27 ) ) -RRB- cord-015021-pol2qm74 715 28 reactivity reactivity NN cord-015021-pol2qm74 715 29 . . . cord-015021-pol2qm74 716 1 Conversely conversely RB cord-015021-pol2qm74 716 2 , , , cord-015021-pol2qm74 716 3 measures measure NNS cord-015021-pol2qm74 716 4 directed direct VBN cord-015021-pol2qm74 716 5 against against IN cord-015021-pol2qm74 716 6 Gram gram NN cord-015021-pol2qm74 716 7 negative negative JJ cord-015021-pol2qm74 716 8 bacterial bacterial JJ cord-015021-pol2qm74 716 9 overgrowth overgrowth NN cord-015021-pol2qm74 716 10 in in IN cord-015021-pol2qm74 716 11 experimental experimental JJ cord-015021-pol2qm74 716 12 peritonitis peritonitis NN cord-015021-pol2qm74 716 13 result result VB cord-015021-pol2qm74 716 14 in in IN cord-015021-pol2qm74 716 15 partial partial JJ cord-015021-pol2qm74 716 16 restoration restoration NN cord-015021-pol2qm74 716 17 of of IN cord-015021-pol2qm74 716 18 impaired impaired JJ cord-015021-pol2qm74 716 19 DH dh NN cord-015021-pol2qm74 716 20 reactivity reactivity NN cord-015021-pol2qm74 716 21 . . . cord-015021-pol2qm74 717 1 To to TO cord-015021-pol2qm74 717 2 ascertain ascertain VB cord-015021-pol2qm74 717 3 the the DT cord-015021-pol2qm74 717 4 role role NN cord-015021-pol2qm74 717 5 of of IN cord-015021-pol2qm74 717 6 the the DT cord-015021-pol2qm74 717 7 liver liver NN cord-015021-pol2qm74 717 8 in in IN cord-015021-pol2qm74 717 9 the the DT cord-015021-pol2qm74 717 10 pathogenesis pathogenesis NN cord-015021-pol2qm74 717 11 of of IN cord-015021-pol2qm74 717 12 these these DT cord-015021-pol2qm74 717 13 alterations alteration NNS cord-015021-pol2qm74 717 14 , , , cord-015021-pol2qm74 717 15 we -PRON- PRP cord-015021-pol2qm74 717 16 studied study VBD cord-015021-pol2qm74 717 17 the the DT cord-015021-pol2qm74 717 18 differential differential JJ cord-015021-pol2qm74 717 19 immunologic immunologic JJ cord-015021-pol2qm74 717 20 sequelae sequela NNS cord-015021-pol2qm74 717 21 of of IN cord-015021-pol2qm74 717 22 portal portal NN cord-015021-pol2qm74 717 23 versus versus IN cord-015021-pol2qm74 717 24 systemic systemic JJ cord-015021-pol2qm74 717 25 ( ( -LRB- cord-015021-pol2qm74 717 26 IVC IVC NNP cord-015021-pol2qm74 717 27 ) ) -RRB- cord-015021-pol2qm74 717 28 infusion infusion NN cord-015021-pol2qm74 717 29 of of IN cord-015021-pol2qm74 717 30 killed kill VBN cord-015021-pol2qm74 717 31 bacteria bacteria NNS cord-015021-pol2qm74 717 32 . . . cord-015021-pol2qm74 718 1 Experimental experimental JJ cord-015021-pol2qm74 718 2 infusion infusion NN cord-015021-pol2qm74 718 3 of of IN cord-015021-pol2qm74 718 4 live live NN cord-015021-pol2qm74 718 5 or or CC cord-015021-pol2qm74 718 6 killed kill VBD cord-015021-pol2qm74 718 7 Gram Gram NNP cord-015021-pol2qm74 718 8 negative negative JJ cord-015021-pol2qm74 718 9 organisms organism NNS cord-015021-pol2qm74 718 10 into into IN cord-015021-pol2qm74 718 11 the the DT cord-015021-pol2qm74 718 12 portal portal JJ cord-015021-pol2qm74 718 13 vein vein NN cord-015021-pol2qm74 718 14 produces produce VBZ cord-015021-pol2qm74 718 15 DH DH NNP cord-015021-pol2qm74 718 16 suppression suppression NN cord-015021-pol2qm74 718 17 in in IN cord-015021-pol2qm74 718 18 rive rive NNP cord-015021-pol2qm74 718 19 , , , cord-015021-pol2qm74 718 20 and and CC cord-015021-pol2qm74 718 21 profound profound JJ cord-015021-pol2qm74 718 22 suppression suppression NN cord-015021-pol2qm74 718 23 of of IN cord-015021-pol2qm74 718 24 mitogen mitogen NN cord-015021-pol2qm74 718 25 - - HYPH cord-015021-pol2qm74 718 26 driven drive VBN cord-015021-pol2qm74 718 27 lymphocyte lymphocyte NN cord-015021-pol2qm74 718 28 proliferation proliferation NN cord-015021-pol2qm74 718 29 in in IN cord-015021-pol2qm74 718 30 vitro vitro FW cord-015021-pol2qm74 718 31 ; ; : cord-015021-pol2qm74 719 1 systemic systemic JJ cord-015021-pol2qm74 719 2 administration administration NN cord-015021-pol2qm74 719 3 of of IN cord-015021-pol2qm74 719 4 the the DT cord-015021-pol2qm74 719 5 same same JJ cord-015021-pol2qm74 719 6 organism organism NN cord-015021-pol2qm74 719 7 has have VBZ cord-015021-pol2qm74 719 8 no no DT cord-015021-pol2qm74 719 9 effect effect NN cord-015021-pol2qm74 719 10 on on IN cord-015021-pol2qm74 719 11 these these DT cord-015021-pol2qm74 719 12 phenomena phenomenon NNS cord-015021-pol2qm74 719 13 . . . cord-015021-pol2qm74 720 1 Suppression suppression NN cord-015021-pol2qm74 720 2 is be VBZ cord-015021-pol2qm74 720 3 TGF3-dependent TGF3-dependent NNP cord-015021-pol2qm74 720 4 , , , cord-015021-pol2qm74 720 5 and and CC cord-015021-pol2qm74 720 6 mediated mediate VBN cord-015021-pol2qm74 720 7 by by IN cord-015021-pol2qm74 720 8 a a DT cord-015021-pol2qm74 720 9 soluble soluble JJ cord-015021-pol2qm74 720 10 factor factor NN cord-015021-pol2qm74 720 11 released release VBN cord-015021-pol2qm74 720 12 by by IN cord-015021-pol2qm74 720 13 fixed fix VBN cord-015021-pol2qm74 720 14 tissue tissue NN cord-015021-pol2qm74 720 15 macrophages macrophage NNS cord-015021-pol2qm74 720 16 of of IN cord-015021-pol2qm74 720 17 the the DT cord-015021-pol2qm74 720 18 lung lung NN cord-015021-pol2qm74 720 19 and and CC cord-015021-pol2qm74 720 20 spleen spleen NNS cord-015021-pol2qm74 720 21 . . . cord-015021-pol2qm74 721 1 The the DT cord-015021-pol2qm74 721 2 suppressive suppressive JJ cord-015021-pol2qm74 721 3 influence influence NN cord-015021-pol2qm74 721 4 appears appear VBZ cord-015021-pol2qm74 721 5 to to TO cord-015021-pol2qm74 721 6 be be VB cord-015021-pol2qm74 721 7 mediated mediate VBN cord-015021-pol2qm74 721 8 at at IN cord-015021-pol2qm74 721 9 the the DT cord-015021-pol2qm74 721 10 level level NN cord-015021-pol2qm74 721 11 of of IN cord-015021-pol2qm74 721 12 interactions interaction NNS cord-015021-pol2qm74 721 13 between between IN cord-015021-pol2qm74 721 14 IL-2 IL-2 NNP cord-015021-pol2qm74 721 15 and and CC cord-015021-pol2qm74 721 16 its -PRON- PRP$ cord-015021-pol2qm74 721 17 high high JJ cord-015021-pol2qm74 721 18 affinity affinity NN cord-015021-pol2qm74 721 19 receptor receptor NN cord-015021-pol2qm74 721 20 . . . cord-015021-pol2qm74 722 1 Release release NN cord-015021-pol2qm74 722 2 of of IN cord-015021-pol2qm74 722 3 this this DT cord-015021-pol2qm74 722 4 factor factor NN cord-015021-pol2qm74 722 5 can can MD cord-015021-pol2qm74 722 6 be be VB cord-015021-pol2qm74 722 7 induced induce VBN cord-015021-pol2qm74 722 8 by by IN cord-015021-pol2qm74 722 9 a a DT cord-015021-pol2qm74 722 10 second second JJ cord-015021-pol2qm74 722 11 circulating circulate VBG cord-015021-pol2qm74 722 12 factor factor NN cord-015021-pol2qm74 722 13 present present JJ cord-015021-pol2qm74 722 14 in in IN cord-015021-pol2qm74 722 15 the the DT cord-015021-pol2qm74 722 16 plasma plasma NN cord-015021-pol2qm74 722 17 of of IN cord-015021-pol2qm74 722 18 portally- portally- NN cord-015021-pol2qm74 722 19 , , , cord-015021-pol2qm74 722 20 but but CC cord-015021-pol2qm74 722 21 not not RB cord-015021-pol2qm74 722 22 systemically systemically RB cord-015021-pol2qm74 722 23 - - HYPH cord-015021-pol2qm74 722 24 infused infuse VBN cord-015021-pol2qm74 722 25 animals animal NNS cord-015021-pol2qm74 722 26 two two CD cord-015021-pol2qm74 722 27 hours hour NNS cord-015021-pol2qm74 722 28 after after IN cord-015021-pol2qm74 722 29 bacterial bacterial JJ cord-015021-pol2qm74 722 30 administration administration NN cord-015021-pol2qm74 722 31 . . . cord-015021-pol2qm74 723 1 These these DT cord-015021-pol2qm74 723 2 studies study NNS cord-015021-pol2qm74 723 3 suggest suggest VBP cord-015021-pol2qm74 723 4 that that IN cord-015021-pol2qm74 723 5 the the DT cord-015021-pol2qm74 723 6 release release NN cord-015021-pol2qm74 723 7 of of IN cord-015021-pol2qm74 723 8 inducible inducible JJ cord-015021-pol2qm74 723 9 immunoregulatory immunoregulatory JJ cord-015021-pol2qm74 723 10 factors factor NNS cord-015021-pol2qm74 723 11 from from IN cord-015021-pol2qm74 723 12 the the DT cord-015021-pol2qm74 723 13 liver liver NN cord-015021-pol2qm74 723 14 , , , cord-015021-pol2qm74 723 15 and and CC cord-015021-pol2qm74 723 16 possibly possibly RB cord-015021-pol2qm74 723 17 from from IN cord-015021-pol2qm74 723 18 the the DT cord-015021-pol2qm74 723 19 gut gut NN cord-015021-pol2qm74 723 20 , , , cord-015021-pol2qm74 723 21 may may MD cord-015021-pol2qm74 723 22 play play VB cord-015021-pol2qm74 723 23 a a DT cord-015021-pol2qm74 723 24 role role NN cord-015021-pol2qm74 723 25 in in IN cord-015021-pol2qm74 723 26 the the DT cord-015021-pol2qm74 723 27 pathogenesis pathogenesis NN cord-015021-pol2qm74 723 28 of of IN cord-015021-pol2qm74 723 29 the the DT cord-015021-pol2qm74 723 30 profound profound JJ cord-015021-pol2qm74 723 31 derangements derangement NNS cord-015021-pol2qm74 723 32 of of IN cord-015021-pol2qm74 723 33 systemic systemic JJ cord-015021-pol2qm74 723 34 immune immune JJ cord-015021-pol2qm74 723 35 homeostasis homeostasis NN cord-015021-pol2qm74 723 36 that that WDT cord-015021-pol2qm74 723 37 accompany accompany VBP cord-015021-pol2qm74 723 38 trauma trauma NN cord-015021-pol2qm74 723 39 and and CC cord-015021-pol2qm74 723 40 critical critical JJ cord-015021-pol2qm74 723 41 illness illness NN cord-015021-pol2qm74 723 42 . . . cord-015021-pol2qm74 724 1 Acad Acad NNP cord-015021-pol2qm74 724 2 . . . cord-015021-pol2qm74 725 1 Hospital Hospital NNP cord-015021-pol2qm74 725 2 St. St. NNP cord-015021-pol2qm74 725 3 Radboud Radboud NNP cord-015021-pol2qm74 725 4 , , , cord-015021-pol2qm74 725 5 Postbus Postbus NNP cord-015021-pol2qm74 725 6 9101,6500 9101,6500 CD cord-015021-pol2qm74 725 7 lib lib NN cord-015021-pol2qm74 726 1 Nijmegen Nijmegen NNP cord-015021-pol2qm74 726 2 Introduction Introduction NNP cord-015021-pol2qm74 726 3 . . . cord-015021-pol2qm74 727 1 The the DT cord-015021-pol2qm74 727 2 central central JJ cord-015021-pol2qm74 727 3 question question NN cord-015021-pol2qm74 727 4 being be VBG cord-015021-pol2qm74 727 5 tested test VBN cord-015021-pol2qm74 727 6 in in IN cord-015021-pol2qm74 727 7 this this DT cord-015021-pol2qm74 727 8 study study NN cord-015021-pol2qm74 727 9 was be VBD cord-015021-pol2qm74 727 10 whether whether IN cord-015021-pol2qm74 727 11 liposome liposome NN cord-015021-pol2qm74 727 12 encapsulated encapsulate VBN cord-015021-pol2qm74 727 13 dichloromethyLene dichloromethylene JJ cord-015021-pol2qm74 727 14 - - HYPH cord-015021-pol2qm74 727 15 diphosphonate diphosphonate JJ cord-015021-pol2qm74 727 16 ( ( -LRB- cord-015021-pol2qm74 727 17 CI2MDP ci2mdp NN cord-015021-pol2qm74 727 18 ) ) -RRB- cord-015021-pol2qm74 727 19 mediated mediate VBN cord-015021-pol2qm74 727 20 elimination elimination NN cord-015021-pol2qm74 727 21 of of IN cord-015021-pol2qm74 727 22 liver liver NN cord-015021-pol2qm74 727 23 and and CC cord-015021-pol2qm74 727 24 splenic splenic JJ cord-015021-pol2qm74 727 25 maorophages maorophage NNS cord-015021-pol2qm74 727 26 would would MD cord-015021-pol2qm74 727 27 influence influence VB cord-015021-pol2qm74 728 1 zymosan zymosan NNP cord-015021-pol2qm74 728 2 induced induce VBD cord-015021-pol2qm74 728 3 systemic systemic JJ cord-015021-pol2qm74 728 4 toxicity toxicity NN cord-015021-pol2qm74 728 5 ( ( -LRB- cord-015021-pol2qm74 728 6 ST ST NNP cord-015021-pol2qm74 728 7 ) ) -RRB- cord-015021-pol2qm74 728 8 and and CC cord-015021-pol2qm74 728 9 bacterial bacterial JJ cord-015021-pol2qm74 728 10 lranslocation lranslocation NN cord-015021-pol2qm74 728 11 ( ( -LRB- cord-015021-pol2qm74 728 12 BT BT NNP cord-015021-pol2qm74 728 13 ) ) -RRB- cord-015021-pol2qm74 728 14 . . . cord-015021-pol2qm74 729 1 Materia|s Materia|s NNP cord-015021-pol2qm74 729 2 and and CC cord-015021-pol2qm74 729 3 Methods Methods NNPS cord-015021-pol2qm74 729 4 . . . cord-015021-pol2qm74 730 1 90 90 CD cord-015021-pol2qm74 730 2 male male JJ cord-015021-pol2qm74 730 3 Swiss Swiss NNP cord-015021-pol2qm74 730 4 ( ( -LRB- cord-015021-pol2qm74 730 5 ICR ICR NNP cord-015021-pol2qm74 730 6 ) ) -RRB- cord-015021-pol2qm74 730 7 mice mouse NNS cord-015021-pol2qm74 730 8 were be VBD cord-015021-pol2qm74 730 9 used use VBN cord-015021-pol2qm74 730 10 weighing weigh VBG cord-015021-pol2qm74 730 11 21 21 CD cord-015021-pol2qm74 730 12 - - SYM cord-015021-pol2qm74 730 13 25 25 CD cord-015021-pol2qm74 730 14 g g NNP cord-015021-pol2qm74 730 15 Elimination Elimination NNP cord-015021-pol2qm74 730 16 of of IN cord-015021-pol2qm74 730 17 liver liver NN cord-015021-pol2qm74 730 18 and and CC cord-015021-pol2qm74 730 19 spleen spleen NN cord-015021-pol2qm74 730 20 macrophages macrophage NNS cord-015021-pol2qm74 730 21 was be VBD cord-015021-pol2qm74 730 22 accomplished accomplish VBN cord-015021-pol2qm74 730 23 by by IN cord-015021-pol2qm74 730 24 intravenous intravenous JJ cord-015021-pol2qm74 730 25 injection injection NN cord-015021-pol2qm74 730 26 of of IN cord-015021-pol2qm74 730 27 200/11 200/11 CD cord-015021-pol2qm74 730 28 suspension suspension NN cord-015021-pol2qm74 730 29 of of IN cord-015021-pol2qm74 730 30 CI2MDP ci2mdp NN cord-015021-pol2qm74 730 31 - - HYPH cord-015021-pol2qm74 730 32 liposome liposome NN cord-015021-pol2qm74 730 33 suspension suspension NN cord-015021-pol2qm74 730 34 . . . cord-015021-pol2qm74 731 1 Control control NN cord-015021-pol2qm74 731 2 mice mouse NNS cord-015021-pol2qm74 731 3 received receive VBD cord-015021-pol2qm74 731 4 an an DT cord-015021-pol2qm74 731 5 i.v i.v NNP cord-015021-pol2qm74 731 6 . . . cord-015021-pol2qm74 731 7 injection injection NN cord-015021-pol2qm74 731 8 with with IN cord-015021-pol2qm74 731 9 200 200 CD cord-015021-pol2qm74 731 10 pt pt NN cord-015021-pol2qm74 731 11 phosphate phosphate NN cord-015021-pol2qm74 731 12 - - HYPH cord-015021-pol2qm74 731 13 buffered buffer VBN cord-015021-pol2qm74 731 14 saline saline NN cord-015021-pol2qm74 731 15 ( ( -LRB- cord-015021-pol2qm74 731 16 PBS PBS NNP cord-015021-pol2qm74 731 17 ) ) -RRB- cord-015021-pol2qm74 731 18 . . . cord-015021-pol2qm74 732 1 Two two CD cord-015021-pol2qm74 732 2 days day NNS cord-015021-pol2qm74 732 3 later later RBR cord-015021-pol2qm74 732 4 all all DT cord-015021-pol2qm74 732 5 mice mouse NNS cord-015021-pol2qm74 732 6 were be VBD cord-015021-pol2qm74 732 7 challenged challenge VBN cord-015021-pol2qm74 732 8 with with IN cord-015021-pol2qm74 732 9 an an DT cord-015021-pol2qm74 732 10 i.p i.p NNP cord-015021-pol2qm74 732 11 . . NNP cord-015021-pol2qm74 732 12 injection injection NN cord-015021-pol2qm74 732 13 of of IN cord-015021-pol2qm74 732 14 zymosan zymosan NNP cord-015021-pol2qm74 732 15 suspended suspend VBN cord-015021-pol2qm74 732 16 in in IN cord-015021-pol2qm74 732 17 paraffin paraffin NN cord-015021-pol2qm74 732 18 ( ( -LRB- cord-015021-pol2qm74 732 19 Z z NN cord-015021-pol2qm74 732 20 ) ) -RRB- cord-015021-pol2qm74 732 21 at at IN cord-015021-pol2qm74 732 22 a a DT cord-015021-pol2qm74 732 23 dosage dosage NN cord-015021-pol2qm74 732 24 Of of IN cord-015021-pol2qm74 732 25 either either DT cord-015021-pol2qm74 732 26 01 01 CD cord-015021-pol2qm74 732 27 mg mg NNP cord-015021-pol2qm74 732 28 / / SYM cord-015021-pol2qm74 732 29 g g NNP cord-015021-pol2qm74 732 30 , , , cord-015021-pol2qm74 732 31 0.5 0.5 CD cord-015021-pol2qm74 732 32 mg mg NNP cord-015021-pol2qm74 732 33 / / SYM cord-015021-pol2qm74 732 34 g g NN cord-015021-pol2qm74 732 35 or or CC cord-015021-pol2qm74 732 36 1.0 1.0 CD cord-015021-pol2qm74 732 37 mg mg NN cord-015021-pol2qm74 732 38 / / SYM cord-015021-pol2qm74 732 39 g g NN cord-015021-pol2qm74 732 40 body body NN cord-015021-pol2qm74 732 41 weight weight NN cord-015021-pol2qm74 732 42 ( ( -LRB- cord-015021-pol2qm74 732 43 n=8 n=8 NN cord-015021-pol2qm74 732 44 in in IN cord-015021-pol2qm74 732 45 each each DT cord-015021-pol2qm74 732 46 group group NN cord-015021-pol2qm74 732 47 ) ) -RRB- cord-015021-pol2qm74 732 48 , , , cord-015021-pol2qm74 732 49 Signs Signs NNPS cord-015021-pol2qm74 732 50 of of IN cord-015021-pol2qm74 732 51 ST ST NNP cord-015021-pol2qm74 732 52 and and CC cord-015021-pol2qm74 732 53 bacterial bacterial JJ cord-015021-pol2qm74 732 54 translocation translocation NN cord-015021-pol2qm74 732 55 BT BT NNP cord-015021-pol2qm74 732 56 were be VBD cord-015021-pol2qm74 732 57 measured measure VBN cord-015021-pol2qm74 732 58 24 24 CD cord-015021-pol2qm74 732 59 hours hour NNS cord-015021-pol2qm74 732 60 later later RB cord-015021-pol2qm74 732 61 The the DT cord-015021-pol2qm74 732 62 ST ST NNP cord-015021-pol2qm74 732 63 was be VBD cord-015021-pol2qm74 732 64 assessed assess VBN cord-015021-pol2qm74 732 65 by by IN cord-015021-pol2qm74 732 66 blindly blindly RB cord-015021-pol2qm74 732 67 grading grade VBG cord-015021-pol2qm74 732 68 the the DT cord-015021-pol2qm74 732 69 degree degree NN cord-015021-pol2qm74 732 70 of of IN cord-015021-pol2qm74 732 71 lethargy lethargy NN cord-015021-pol2qm74 732 72 , , , cord-015021-pol2qm74 732 73 conjunctivitis conjunctivitis NN cord-015021-pol2qm74 732 74 , , , cord-015021-pol2qm74 732 75 diarrhea diarrhea NN cord-015021-pol2qm74 732 76 , , , cord-015021-pol2qm74 732 77 and and CC cord-015021-pol2qm74 732 78 ruffled ruffled JJ cord-015021-pol2qm74 732 79 fur fur NN cord-015021-pol2qm74 732 80 of of IN cord-015021-pol2qm74 732 81 each each DT cord-015021-pol2qm74 732 82 mouse mouse NN cord-015021-pol2qm74 732 83 on on IN cord-015021-pol2qm74 732 84 a a DT cord-015021-pol2qm74 732 85 four four CD cord-015021-pol2qm74 732 86 point point NN cord-015021-pol2qm74 732 87 scale scale NN cord-015021-pol2qm74 732 88 . . . cord-015021-pol2qm74 733 1 BT BT NNP cord-015021-pol2qm74 733 2 to to IN cord-015021-pol2qm74 733 3 the the DT cord-015021-pol2qm74 733 4 mesenteric mesenteric JJ cord-015021-pol2qm74 733 5 lymph lymph NN cord-015021-pol2qm74 733 6 nodes node NNS cord-015021-pol2qm74 733 7 ( ( -LRB- cord-015021-pol2qm74 733 8 MLN mln NN cord-015021-pol2qm74 733 9 ) ) -RRB- cord-015021-pol2qm74 733 10 and and CC cord-015021-pol2qm74 733 11 systemic systemic JJ cord-015021-pol2qm74 733 12 organs organ NNS cord-015021-pol2qm74 733 13 ( ( -LRB- cord-015021-pol2qm74 733 14 liver liver NN cord-015021-pol2qm74 733 15 , , , cord-015021-pol2qm74 733 16 spleen spleen NNS cord-015021-pol2qm74 733 17 , , , cord-015021-pol2qm74 733 18 lung lung NN cord-015021-pol2qm74 733 19 and and CC cord-015021-pol2qm74 733 20 blood blood NN cord-015021-pol2qm74 733 21 ) ) -RRB- cord-015021-pol2qm74 733 22 was be VBD cord-015021-pol2qm74 733 23 tested test VBN cord-015021-pol2qm74 733 24 by by IN cord-015021-pol2qm74 733 25 culturing culture VBG cord-015021-pol2qm74 733 26 on on IN cord-015021-pol2qm74 733 27 blood blood NN cord-015021-pol2qm74 733 28 and and CC cord-015021-pol2qm74 733 29 MacConkey MacConkey NNP cord-015021-pol2qm74 733 30 's 's POS cord-015021-pol2qm74 733 31 agar agar NN cord-015021-pol2qm74 733 32 At at IN cord-015021-pol2qm74 733 33 the the DT cord-015021-pol2qm74 733 34 time time NN cord-015021-pol2qm74 733 35 of of IN cord-015021-pol2qm74 733 36 sacrifice sacrifice NN cord-015021-pol2qm74 733 37 sections section NNS cord-015021-pol2qm74 733 38 of of IN cord-015021-pol2qm74 733 39 the the DT cord-015021-pol2qm74 733 40 distal distal JJ cord-015021-pol2qm74 733 41 ileum ileum NN cord-015021-pol2qm74 733 42 were be VBD cord-015021-pol2qm74 733 43 taken take VBN cord-015021-pol2qm74 733 44 for for IN cord-015021-pol2qm74 733 45 histology histology NN cord-015021-pol2qm74 733 46 . . . cord-015021-pol2qm74 734 1 An an DT cord-015021-pol2qm74 734 2 additional additional JJ cord-015021-pol2qm74 734 3 two two CD cord-015021-pol2qm74 734 4 control control NN cord-015021-pol2qm74 734 5 groups group NNS cord-015021-pol2qm74 734 6 ( ( -LRB- cord-015021-pol2qm74 734 7 n=6 n=6 JJ cord-015021-pol2qm74 734 8 in in IN cord-015021-pol2qm74 734 9 each each DT cord-015021-pol2qm74 734 10 group group NN cord-015021-pol2qm74 734 11 ) ) -RRB- cord-015021-pol2qm74 734 12 were be VBD cord-015021-pol2qm74 734 13 tested test VBN cord-015021-pol2qm74 734 14 to to TO cord-015021-pol2qm74 734 15 verify verify VB cord-015021-pol2qm74 734 16 that that IN cord-015021-pol2qm74 734 17 neither neither CC cord-015021-pol2qm74 734 18 paraffin paraffin NN cord-015021-pol2qm74 734 19 nor nor CC cord-015021-pol2qm74 734 20 PBS PBS NNP cord-015021-pol2qm74 734 21 or or CC cord-015021-pol2qm74 734 22 CI2MDPqiposome CI2MDPqiposome NNP cord-015021-pol2qm74 734 23 suspension suspension NN cord-015021-pol2qm74 734 24 alone alone RB cord-015021-pol2qm74 734 25 induced induce VBN cord-015021-pol2qm74 734 26 BT BT NNP cord-015021-pol2qm74 734 27 or or CC cord-015021-pol2qm74 734 28 ST ST NNP cord-015021-pol2qm74 734 29 . . . cord-015021-pol2qm74 735 1 Furthermore furthermore RB cord-015021-pol2qm74 735 2 survival survival NN cord-015021-pol2qm74 735 3 over over IN cord-015021-pol2qm74 735 4 a a DT cord-015021-pol2qm74 735 5 12-day 12-day CD cord-015021-pol2qm74 735 6 period period NN cord-015021-pol2qm74 735 7 was be VBD cord-015021-pol2qm74 735 8 assessed assess VBN cord-015021-pol2qm74 735 9 in in IN cord-015021-pol2qm74 735 10 a a DT cord-015021-pol2qm74 735 11 control control NN cord-015021-pol2qm74 735 12 and and CC cord-015021-pol2qm74 735 13 macrophage macrophage NN cord-015021-pol2qm74 735 14 - - HYPH cord-015021-pol2qm74 735 15 depleted deplete VBN cord-015021-pol2qm74 735 16 group group NN cord-015021-pol2qm74 735 17 with with IN cord-015021-pol2qm74 735 18 a a DT cord-015021-pol2qm74 735 19 dose dose NN cord-015021-pol2qm74 735 20 of of IN cord-015021-pol2qm74 735 21 1D 1d CD cord-015021-pol2qm74 735 22 mg mg NNP cord-015021-pol2qm74 735 23 / / SYM cord-015021-pol2qm74 735 24 g g NNP cord-015021-pol2qm74 735 25 Z. Z. NNP cord-015021-pol2qm74 735 26 Results Results NNP cord-015021-pol2qm74 735 27 . . . cord-015021-pol2qm74 736 1 Neither neither CC cord-015021-pol2qm74 736 2 the the DT cord-015021-pol2qm74 736 3 paraffin paraffin NN cord-015021-pol2qm74 736 4 nor nor CC cord-015021-pol2qm74 736 5 CI2MDP ci2mdp NN cord-015021-pol2qm74 736 6 - - HYPH cord-015021-pol2qm74 736 7 tiposome tiposome NN cord-015021-pol2qm74 736 8 suspension suspension NN cord-015021-pol2qm74 736 9 induced induce VBN cord-015021-pol2qm74 736 10 BT BT NNP cord-015021-pol2qm74 736 11 or or CC cord-015021-pol2qm74 736 12 ST ST NNP cord-015021-pol2qm74 737 1 The the DT cord-015021-pol2qm74 737 2 incidence incidence NN cord-015021-pol2qm74 737 3 of of IN cord-015021-pol2qm74 737 4 bacterial bacterial JJ cord-015021-pol2qm74 737 5 translocation translocation NN cord-015021-pol2qm74 737 6 to to IN cord-015021-pol2qm74 737 7 the the DT cord-015021-pol2qm74 737 8 MLN mln NN cord-015021-pol2qm74 737 9 was be VBD cord-015021-pol2qm74 737 10 similar similar JJ cord-015021-pol2qm74 737 11 between between IN cord-015021-pol2qm74 737 12 macrophage macrophage NN cord-015021-pol2qm74 737 13 depleted deplete VBN cord-015021-pol2qm74 737 14 and and CC cord-015021-pol2qm74 737 15 control control NN cord-015021-pol2qm74 737 16 groups group NNS cord-015021-pol2qm74 737 17 . . . cord-015021-pol2qm74 738 1 However however RB cord-015021-pol2qm74 738 2 , , , cord-015021-pol2qm74 738 3 macrophage macrophage NN cord-015021-pol2qm74 738 4 depletion depletion NN cord-015021-pol2qm74 738 5 was be VBD cord-015021-pol2qm74 738 6 associated associate VBN cord-015021-pol2qm74 738 7 with with IN cord-015021-pol2qm74 738 8 a a DT cord-015021-pol2qm74 738 9 significantly significantly RB cord-015021-pol2qm74 738 10 higher high JJR cord-015021-pol2qm74 738 11 incidence incidence NN cord-015021-pol2qm74 738 12 of of IN cord-015021-pol2qm74 738 13 systemic systemic JJ cord-015021-pol2qm74 738 14 spread spread NN cord-015021-pol2qm74 738 15 of of IN cord-015021-pol2qm74 738 16 bacteria bacteria NNS cord-015021-pol2qm74 738 17 . . . cord-015021-pol2qm74 739 1 Data datum NNS cord-015021-pol2qm74 739 2 expressed express VBN cord-015021-pol2qm74 739 3 as as IN cord-015021-pol2qm74 739 4 positive positive JJ cord-015021-pol2qm74 739 5 tissues tissue NNS cord-015021-pol2qm74 739 6 / / SYM cord-015021-pol2qm74 739 7 total total JJ cord-015021-pol2qm74 739 8 tissues tissue NNS cord-015021-pol2qm74 739 9 tested test VBN cord-015021-pol2qm74 739 10 : : : cord-015021-pol2qm74 739 11 11/32 11/32 CD cord-015021-pol2qm74 739 12 vs. vs. CC cord-015021-pol2qm74 739 13 1/32 1/32 CD cord-015021-pol2qm74 739 14 at at IN cord-015021-pol2qm74 739 15 0.1 0.1 CD cord-015021-pol2qm74 739 16 mg mg NN cord-015021-pol2qm74 739 17 / / SYM cord-015021-pol2qm74 739 18 g g NNP cord-015021-pol2qm74 739 19 Zymosan Zymosan NNP cord-015021-pol2qm74 739 20 ( ( -LRB- cord-015021-pol2qm74 739 21 p p NN cord-015021-pol2qm74 739 22 ~ ~ CD cord-015021-pol2qm74 739 23 O.01 o.01 CD cord-015021-pol2qm74 739 24 ) ) -RRB- cord-015021-pol2qm74 739 25 ; ; : cord-015021-pol2qm74 739 26 19132 19132 CD cord-015021-pol2qm74 739 27 vs. vs. CC cord-015021-pol2qm74 739 28 10132 10132 CD cord-015021-pol2qm74 739 29 at at IN cord-015021-pol2qm74 739 30 05 05 CD cord-015021-pol2qm74 739 31 mg mg NNP cord-015021-pol2qm74 739 32 / / SYM cord-015021-pol2qm74 739 33 g g NNP cord-015021-pol2qm74 739 34 Zymosan Zymosan NNP cord-015021-pol2qm74 739 35 ( ( -LRB- cord-015021-pol2qm74 739 36 p p NN cord-015021-pol2qm74 739 37 ~ ~ NFP cord-015021-pol2qm74 739 38 Q05 Q05 NNP cord-015021-pol2qm74 739 39 ) ) -RRB- cord-015021-pol2qm74 739 40 ; ; . cord-015021-pol2qm74 740 1 23/32 23/32 CD cord-015021-pol2qm74 740 2 vs. vs. IN cord-015021-pol2qm74 740 3 11/32 11/32 CD cord-015021-pol2qm74 740 4 st st NNP cord-015021-pol2qm74 740 5 1.0 1.0 CD cord-015021-pol2qm74 740 6 mg mg NNP cord-015021-pol2qm74 740 7 / / SYM cord-015021-pol2qm74 740 8 g g NNP cord-015021-pol2qm74 740 9 Zymosan Zymosan NNP cord-015021-pol2qm74 740 10 ( ( -LRB- cord-015021-pol2qm74 740 11 p~ p~ XX cord-015021-pol2qm74 741 1 O.O1).The o.o1).the JJ cord-015021-pol2qm74 741 2 magnitude magnitude NN cord-015021-pol2qm74 741 3 of of IN cord-015021-pol2qm74 741 4 BT BT NNP cord-015021-pol2qm74 741 5 however however RB cord-015021-pol2qm74 741 6 did do VBD cord-015021-pol2qm74 741 7 not not RB cord-015021-pol2qm74 741 8 show show VB cord-015021-pol2qm74 741 9 any any DT cord-015021-pol2qm74 741 10 differences difference NNS cord-015021-pol2qm74 741 11 . . . cord-015021-pol2qm74 742 1 Although although IN cord-015021-pol2qm74 742 2 systemic systemic JJ cord-015021-pol2qm74 742 3 BT BT NNP cord-015021-pol2qm74 742 4 was be VBD cord-015021-pol2qm74 742 5 greater great JJR cord-015021-pol2qm74 742 6 in in IN cord-015021-pol2qm74 742 7 the the DT cord-015021-pol2qm74 742 8 macrophage macrophage NN cord-015021-pol2qm74 742 9 depleted deplete VBN cord-015021-pol2qm74 742 10 groups group NNS cord-015021-pol2qm74 742 11 , , , cord-015021-pol2qm74 742 12 the the DT cord-015021-pol2qm74 742 13 systemic systemic JJ cord-015021-pol2qm74 742 14 toxic toxic JJ cord-015021-pol2qm74 742 15 response response NN cord-015021-pol2qm74 742 16 was be VBD cord-015021-pol2qm74 742 17 significantly significantly RB cord-015021-pol2qm74 742 18 less less JJR cord-015021-pol2qm74 742 19 at at IN cord-015021-pol2qm74 742 20 doses dose NNS cord-015021-pol2qm74 742 21 of of IN cord-015021-pol2qm74 742 22 0.5 0.5 CD cord-015021-pol2qm74 742 23 mg mg NNP cord-015021-pol2qm74 742 24 / / SYM cord-015021-pol2qm74 742 25 g g NNP cord-015021-pol2qm74 742 26 Zymosan Zymosan NNP cord-015021-pol2qm74 742 27 ( ( -LRB- cord-015021-pol2qm74 742 28 3.14 3.14 CD cord-015021-pol2qm74 742 29 -+ -+ NNP cord-015021-pol2qm74 742 30 0.69 0.69 CD cord-015021-pol2qm74 742 31 vs. vs. NN cord-015021-pol2qm74 742 32 7.13 7.13 CD cord-015021-pol2qm74 742 33 -+ -+ NNP cord-015021-pol2qm74 742 34 3 3 CD cord-015021-pol2qm74 742 35 , , , cord-015021-pol2qm74 742 36 p p NN cord-015021-pol2qm74 742 37 ~ ~ CD cord-015021-pol2qm74 742 38 O.01 o.01 CD cord-015021-pol2qm74 742 39 ) ) -RRB- cord-015021-pol2qm74 742 40 and and CC cord-015021-pol2qm74 742 41 1.0 1.0 CD cord-015021-pol2qm74 742 42 mg mg NNP cord-015021-pol2qm74 742 43 / / SYM cord-015021-pol2qm74 742 44 g g NNP cord-015021-pol2qm74 742 45 Zymosan Zymosan NNP cord-015021-pol2qm74 742 46 ( ( -LRB- cord-015021-pol2qm74 742 47 4.38 4.38 CD cord-015021-pol2qm74 742 48 -+2.50 -+2.50 NNP cord-015021-pol2qm74 742 49 vs. vs. NN cord-015021-pol2qm74 742 50 11.25 11.25 CD cord-015021-pol2qm74 742 51 -+ -+ . cord-015021-pol2qm74 742 52 2.5 2.5 CD cord-015021-pol2qm74 742 53 , , , cord-015021-pol2qm74 742 54 p<_.O.01 p<_.O.01 NNP cord-015021-pol2qm74 742 55 ) ) -RRB- cord-015021-pol2qm74 742 56 . . . cord-015021-pol2qm74 743 1 The the DT cord-015021-pol2qm74 743 2 12 12 CD cord-015021-pol2qm74 743 3 day day NN cord-015021-pol2qm74 743 4 mortality mortality NN cord-015021-pol2qm74 743 5 after after IN cord-015021-pol2qm74 743 6 1.0 1.0 CD cord-015021-pol2qm74 743 7 mg mg NNP cord-015021-pol2qm74 743 8 / / SYM cord-015021-pol2qm74 743 9 g g NNP cord-015021-pol2qm74 743 10 Zymosan Zymosan NNP cord-015021-pol2qm74 743 11 was be VBD cord-015021-pol2qm74 743 12 27 27 CD cord-015021-pol2qm74 743 13 % % NN cord-015021-pol2qm74 743 14 in in IN cord-015021-pol2qm74 743 15 the the DT cord-015021-pol2qm74 743 16 control control NN cord-015021-pol2qm74 743 17 group group NN cord-015021-pol2qm74 743 18 and and CC cord-015021-pol2qm74 743 19 0 0 CD cord-015021-pol2qm74 743 20 % % NN cord-015021-pol2qm74 743 21 in in IN cord-015021-pol2qm74 743 22 the the DT cord-015021-pol2qm74 743 23 macrophage macrophage NN cord-015021-pol2qm74 743 24 depleted deplete VBN cord-015021-pol2qm74 743 25 group group NN cord-015021-pol2qm74 743 26 ( ( -LRB- cord-015021-pol2qm74 743 27 p p NN cord-015021-pol2qm74 743 28 = = SYM cord-015021-pol2qm74 743 29 O.05 o.05 NN cord-015021-pol2qm74 743 30 ) ) -RRB- cord-015021-pol2qm74 743 31 . . . cord-015021-pol2qm74 744 1 Histology histology NN cord-015021-pol2qm74 744 2 did do VBD cord-015021-pol2qm74 744 3 not not RB cord-015021-pol2qm74 744 4 show show VB cord-015021-pol2qm74 744 5 any any DT cord-015021-pol2qm74 744 6 differences difference NNS cord-015021-pol2qm74 744 7 between between IN cord-015021-pol2qm74 744 8 the the DT cord-015021-pol2qm74 744 9 control control NN cord-015021-pol2qm74 744 10 and and CC cord-015021-pol2qm74 744 11 macrophage macrophage NN cord-015021-pol2qm74 744 12 depleted deplete VBN cord-015021-pol2qm74 744 13 groups group NNS cord-015021-pol2qm74 744 14 . . . cord-015021-pol2qm74 745 1 Conclusion conclusion NN cord-015021-pol2qm74 745 2 . . . cord-015021-pol2qm74 746 1 The the DT cord-015021-pol2qm74 746 2 lethal lethal JJ cord-015021-pol2qm74 746 3 and and CC cord-015021-pol2qm74 746 4 toxic toxic JJ cord-015021-pol2qm74 746 5 effects effect NNS cord-015021-pol2qm74 746 6 of of IN cord-015021-pol2qm74 746 7 zymosan zymosan NNP cord-015021-pol2qm74 746 8 in in IN cord-015021-pol2qm74 746 9 this this DT cord-015021-pol2qm74 746 10 model model NN cord-015021-pol2qm74 746 11 appear appear VBP cord-015021-pol2qm74 746 12 to to TO cord-015021-pol2qm74 746 13 be be VB cord-015021-pol2qm74 746 14 more more RBR cord-015021-pol2qm74 746 15 related related JJ cord-015021-pol2qm74 746 16 to to IN cord-015021-pol2qm74 746 17 the the DT cord-015021-pol2qm74 746 18 excessive excessive JJ cord-015021-pol2qm74 746 19 activation activation NN cord-015021-pol2qm74 746 20 of of IN cord-015021-pol2qm74 746 21 macrophages macrophage NNS cord-015021-pol2qm74 746 22 than than IN cord-015021-pol2qm74 746 23 to to IN cord-015021-pol2qm74 746 24 the the DT cord-015021-pol2qm74 746 25 systemic systemic JJ cord-015021-pol2qm74 746 26 spread spread NN cord-015021-pol2qm74 746 27 of of IN cord-015021-pol2qm74 746 28 bacteria bacteria NNS cord-015021-pol2qm74 746 29 . . . cord-015021-pol2qm74 747 1 Bacterial bacterial JJ cord-015021-pol2qm74 747 2 translocation translocation NN cord-015021-pol2qm74 747 3 ( ( -LRB- cord-015021-pol2qm74 747 4 BT BT NNP cord-015021-pol2qm74 747 5 ) ) -RRB- cord-015021-pol2qm74 747 6 in in IN cord-015021-pol2qm74 747 7 hemorrhagic hemorrhagic JJ cord-015021-pol2qm74 747 8 shock shock NN cord-015021-pol2qm74 747 9 was be VBD cord-015021-pol2qm74 747 10 studied study VBN cord-015021-pol2qm74 747 11 using use VBG cord-015021-pol2qm74 747 12 a a DT cord-015021-pol2qm74 747 13 porcine porcine JJ cord-015021-pol2qm74 747 14 model model NN cord-015021-pol2qm74 747 15 . . . cord-015021-pol2qm74 748 1 In in IN cord-015021-pol2qm74 748 2 this this DT cord-015021-pol2qm74 748 3 study study NN cord-015021-pol2qm74 748 4 three three CD cord-015021-pol2qm74 748 5 groups group NNS cord-015021-pol2qm74 748 6 were be VBD cord-015021-pol2qm74 748 7 randomized randomize VBN cord-015021-pol2qm74 748 8 : : : cord-015021-pol2qm74 748 9 one one CD cord-015021-pol2qm74 748 10 control control NN cord-015021-pol2qm74 748 11 ( ( -LRB- cord-015021-pol2qm74 748 12 n=3 n=3 NN cord-015021-pol2qm74 748 13 ) ) -RRB- cord-015021-pol2qm74 748 14 and and CC cord-015021-pol2qm74 748 15 two two CD cord-015021-pol2qm74 748 16 experimental experimental JJ cord-015021-pol2qm74 748 17 ( ( -LRB- cord-015021-pol2qm74 748 18 n=6 n=6 JJ cord-015021-pol2qm74 748 19 each each DT cord-015021-pol2qm74 748 20 ) ) -RRB- cord-015021-pol2qm74 748 21 . . . cord-015021-pol2qm74 749 1 A a DT cord-015021-pol2qm74 749 2 portal portal JJ cord-015021-pol2qm74 749 3 vein vein NN cord-015021-pol2qm74 749 4 catheter catheter NN cord-015021-pol2qm74 749 5 was be VBD cord-015021-pol2qm74 749 6 placed place VBN cord-015021-pol2qm74 749 7 and and CC cord-015021-pol2qm74 749 8 remained remain VBN cord-015021-pol2qm74 749 9 in in IN cord-015021-pol2qm74 749 10 situ situ NN cord-015021-pol2qm74 749 11 48 48 CD cord-015021-pol2qm74 749 12 hrs hrs NN cord-015021-pol2qm74 749 13 . . . cord-015021-pol2qm74 750 1 A a DT cord-015021-pol2qm74 750 2 femoral femoral JJ cord-015021-pol2qm74 750 3 artery artery NN cord-015021-pol2qm74 750 4 and and CC cord-015021-pol2qm74 750 5 vein vein NN cord-015021-pol2qm74 750 6 catheter catheter NN cord-015021-pol2qm74 750 7 were be VBD cord-015021-pol2qm74 750 8 in in IN cord-015021-pol2qm74 750 9 place place NN cord-015021-pol2qm74 750 10 12 12 CD cord-015021-pol2qm74 750 11 hrs hrs NN cord-015021-pol2qm74 750 12 . . . cord-015021-pol2qm74 751 1 The the DT cord-015021-pol2qm74 751 2 arterial arterial JJ cord-015021-pol2qm74 751 3 eaanula eaanula NN cord-015021-pol2qm74 751 4 was be VBD cord-015021-pol2qm74 751 5 used use VBN cord-015021-pol2qm74 751 6 for for IN cord-015021-pol2qm74 751 7 monitoring monitor VBG cord-015021-pol2qm74 751 8 mean mean JJ cord-015021-pol2qm74 751 9 arterial arterial JJ cord-015021-pol2qm74 751 10 pressure pressure NN cord-015021-pol2qm74 751 11 ( ( -LRB- cord-015021-pol2qm74 751 12 MAP MAP NNP cord-015021-pol2qm74 751 13 ) ) -RRB- cord-015021-pol2qm74 751 14 in in IN cord-015021-pol2qm74 751 15 all all DT cord-015021-pol2qm74 751 16 animals animal NNS cord-015021-pol2qm74 751 17 and and CC cord-015021-pol2qm74 751 18 to to TO cord-015021-pol2qm74 751 19 bleed bleed VB cord-015021-pol2qm74 751 20 the the DT cord-015021-pol2qm74 751 21 experimental experimental JJ cord-015021-pol2qm74 751 22 animals animal NNS cord-015021-pol2qm74 751 23 and and CC cord-015021-pol2qm74 751 24 the the DT cord-015021-pol2qm74 751 25 venous venous JJ cord-015021-pol2qm74 751 26 cannula cannula NN cord-015021-pol2qm74 751 27 to to IN cord-015021-pol2qm74 751 28 repelfuse repelfuse NNP cord-015021-pol2qm74 751 29 with with IN cord-015021-pol2qm74 751 30 Ringer Ringer NNP cord-015021-pol2qm74 751 31 's 's POS cord-015021-pol2qm74 751 32 lactate lactate NN cord-015021-pol2qm74 751 33 ( ( -LRB- cord-015021-pol2qm74 751 34 RL RL NNP cord-015021-pol2qm74 751 35 ) ) -RRB- cord-015021-pol2qm74 751 36 or or CC cord-015021-pol2qm74 751 37 autologous autologous JJ cord-015021-pol2qm74 751 38 blood blood NN cord-015021-pol2qm74 751 39 ( ( -LRB- cord-015021-pol2qm74 751 40 AB AB NNP cord-015021-pol2qm74 751 41 ) ) -RRB- cord-015021-pol2qm74 751 42 . . . cord-015021-pol2qm74 752 1 Baseline baseline JJ cord-015021-pol2qm74 752 2 samples sample NNS cord-015021-pol2qm74 752 3 and and CC cord-015021-pol2qm74 752 4 values value NNS cord-015021-pol2qm74 752 5 were be VBD cord-015021-pol2qm74 752 6 taken take VBN cord-015021-pol2qm74 752 7 in in IN cord-015021-pol2qm74 752 8 this this DT cord-015021-pol2qm74 752 9 period period NN cord-015021-pol2qm74 752 10 . . . cord-015021-pol2qm74 753 1 Control control NN cord-015021-pol2qm74 753 2 animals animal NNS cord-015021-pol2qm74 753 3 were be VBD cord-015021-pol2qm74 753 4 observed observe VBN cord-015021-pol2qm74 753 5 for for IN cord-015021-pol2qm74 753 6 a a DT cord-015021-pol2qm74 753 7 sham sham JJ cord-015021-pol2qm74 753 8 shock shock NN cord-015021-pol2qm74 753 9 period period NN cord-015021-pol2qm74 753 10 of of IN cord-015021-pol2qm74 753 11 6.5 6.5 CD cord-015021-pol2qm74 753 12 hrs hrs NN cord-015021-pol2qm74 753 13 . . . cord-015021-pol2qm74 753 14 , , , cord-015021-pol2qm74 753 15 given give VBN cord-015021-pol2qm74 753 16 2 2 CD cord-015021-pol2qm74 753 17 more more JJR cord-015021-pol2qm74 753 18 hours hour NNS cord-015021-pol2qm74 753 19 of of IN cord-015021-pol2qm74 753 20 anesthesia anesthesia NN cord-015021-pol2qm74 753 21 , , , cord-015021-pol2qm74 753 22 and and CC cord-015021-pol2qm74 753 23 studied study VBD cord-015021-pol2qm74 753 24 for for IN cord-015021-pol2qm74 753 25 further further JJ cord-015021-pol2qm74 753 26 48 48 CD cord-015021-pol2qm74 753 27 hrs hrs NN cord-015021-pol2qm74 753 28 . . . cord-015021-pol2qm74 754 1 40 40 CD cord-015021-pol2qm74 754 2 % % NN cord-015021-pol2qm74 754 3 of of IN cord-015021-pol2qm74 754 4 the the DT cord-015021-pol2qm74 754 5 estimated estimate VBN cord-015021-pol2qm74 754 6 blood blood NN cord-015021-pol2qm74 754 7 volume volume NN cord-015021-pol2qm74 754 8 was be VBD cord-015021-pol2qm74 754 9 withdrawn withdraw VBN cord-015021-pol2qm74 754 10 from from IN cord-015021-pol2qm74 754 11 each each DT cord-015021-pol2qm74 754 12 experimental experimental JJ cord-015021-pol2qm74 754 13 animal animal NN cord-015021-pol2qm74 754 14 over over IN cord-015021-pol2qm74 754 15 30 30 CD cord-015021-pol2qm74 754 16 min min NN cord-015021-pol2qm74 754 17 . . . cord-015021-pol2qm74 755 1 These these DT cord-015021-pol2qm74 755 2 animals animal NNS cord-015021-pol2qm74 755 3 were be VBD cord-015021-pol2qm74 755 4 kept keep VBN cord-015021-pol2qm74 755 5 in in IN cord-015021-pol2qm74 755 6 shock shock NN cord-015021-pol2qm74 755 7 for for IN cord-015021-pol2qm74 755 8 6.5 6.5 CD cord-015021-pol2qm74 755 9 hrs hrs NN cord-015021-pol2qm74 755 10 . . . cord-015021-pol2qm74 756 1 At at IN cord-015021-pol2qm74 756 2 the the DT cord-015021-pol2qm74 756 3 end end NN cord-015021-pol2qm74 756 4 of of IN cord-015021-pol2qm74 756 5 the the DT cord-015021-pol2qm74 756 6 shock shock NN cord-015021-pol2qm74 756 7 one one CD cord-015021-pol2qm74 756 8 group group NN cord-015021-pol2qm74 756 9 was be VBD cord-015021-pol2qm74 756 10 perfused perfuse VBN cord-015021-pol2qm74 756 11 with with IN cord-015021-pol2qm74 756 12 RL RL NNP cord-015021-pol2qm74 756 13 and and CC cord-015021-pol2qm74 756 14 the the DT cord-015021-pol2qm74 756 15 other other JJ cord-015021-pol2qm74 756 16 with with IN cord-015021-pol2qm74 756 17 AB AB NNP cord-015021-pol2qm74 756 18 . . . cord-015021-pol2qm74 757 1 Two two CD cord-015021-pol2qm74 757 2 hours hour NNS cord-015021-pol2qm74 757 3 later later RB cord-015021-pol2qm74 757 4 they -PRON- PRP cord-015021-pol2qm74 757 5 were be VBD cord-015021-pol2qm74 757 6 extubated extubate VBN cord-015021-pol2qm74 757 7 and and CC cord-015021-pol2qm74 757 8 further further RB cord-015021-pol2qm74 757 9 studied study VBN cord-015021-pol2qm74 757 10 for for IN cord-015021-pol2qm74 757 11 48 48 CD cord-015021-pol2qm74 757 12 hrs hrs NN cord-015021-pol2qm74 757 13 . . . cord-015021-pol2qm74 758 1 Samples sample NNS cord-015021-pol2qm74 758 2 from from IN cord-015021-pol2qm74 758 3 portal portal JJ cord-015021-pol2qm74 758 4 blood blood NN cord-015021-pol2qm74 758 5 for for IN cord-015021-pol2qm74 758 6 cultures culture NNS cord-015021-pol2qm74 758 7 and and CC cord-015021-pol2qm74 758 8 measurement measurement NN cord-015021-pol2qm74 758 9 of of IN cord-015021-pol2qm74 758 10 Leukotriene Leukotriene NNP cord-015021-pol2qm74 758 11 B4 B4 NNP cord-015021-pol2qm74 758 12 ( ( -LRB- cord-015021-pol2qm74 758 13 LTB4 LTB4 NNP cord-015021-pol2qm74 758 14 ) ) -RRB- cord-015021-pol2qm74 758 15 , , , cord-015021-pol2qm74 758 16 Prostaglandin prostaglandin NN cord-015021-pol2qm74 758 17 E2 E2 NNP cord-015021-pol2qm74 758 18 ( ( -LRB- cord-015021-pol2qm74 758 19 PGE2 PGE2 NNP cord-015021-pol2qm74 758 20 ) ) -RRB- cord-015021-pol2qm74 758 21 , , , cord-015021-pol2qm74 758 22 and and CC cord-015021-pol2qm74 758 23 nitric nitric NN cord-015021-pol2qm74 758 24 oxide oxide NN cord-015021-pol2qm74 759 1 ( ( -LRB- cord-015021-pol2qm74 759 2 NO no UH cord-015021-pol2qm74 759 3 ) ) -RRB- cord-015021-pol2qm74 759 4 metabolites metabolite NNS cord-015021-pol2qm74 759 5 were be VBD cord-015021-pol2qm74 759 6 taken take VBN cord-015021-pol2qm74 759 7 from from IN cord-015021-pol2qm74 759 8 all all DT cord-015021-pol2qm74 759 9 animals animal NNS cord-015021-pol2qm74 759 10 at at IN cord-015021-pol2qm74 759 11 intervals interval NNS cord-015021-pol2qm74 759 12 beyond beyond IN cord-015021-pol2qm74 759 13 baseline baseline NN cord-015021-pol2qm74 759 14 up up IN cord-015021-pol2qm74 759 15 to to IN cord-015021-pol2qm74 759 16 48 48 CD cord-015021-pol2qm74 759 17 hrs hrs NN cord-015021-pol2qm74 759 18 . . . cord-015021-pol2qm74 760 1 After after IN cord-015021-pol2qm74 760 2 48 48 CD cord-015021-pol2qm74 760 3 hrs hrs NN cord-015021-pol2qm74 760 4 . . . cord-015021-pol2qm74 761 1 under under IN cord-015021-pol2qm74 761 2 general general JJ cord-015021-pol2qm74 761 3 anesthesia anesthesia NNP cord-015021-pol2qm74 761 4 a a DT cord-015021-pol2qm74 761 5 second second JJ cord-015021-pol2qm74 761 6 laparotomy laparotomy NN cord-015021-pol2qm74 761 7 was be VBD cord-015021-pol2qm74 761 8 performed perform VBN cord-015021-pol2qm74 761 9 and and CC cord-015021-pol2qm74 761 10 samples sample NNS cord-015021-pol2qm74 761 11 for for IN cord-015021-pol2qm74 761 12 culture culture NN cord-015021-pol2qm74 761 13 from from IN cord-015021-pol2qm74 761 14 mesenteric mesenteric JJ cord-015021-pol2qm74 761 15 lymph lymph NN cord-015021-pol2qm74 761 16 nodes node NNS cord-015021-pol2qm74 761 17 ( ( -LRB- cord-015021-pol2qm74 761 18 MIN MIN NNP cord-015021-pol2qm74 761 19 ) ) -RRB- cord-015021-pol2qm74 761 20 , , , cord-015021-pol2qm74 761 21 liver liver NN cord-015021-pol2qm74 761 22 and and CC cord-015021-pol2qm74 761 23 spleen spleen NNS cord-015021-pol2qm74 761 24 were be VBD cord-015021-pol2qm74 761 25 taken take VBN cord-015021-pol2qm74 761 26 ; ; : cord-015021-pol2qm74 761 27 as as RB cord-015021-pol2qm74 761 28 well well RB cord-015021-pol2qm74 761 29 as as IN cord-015021-pol2qm74 761 30 samples sample NNS cord-015021-pol2qm74 761 31 for for IN cord-015021-pol2qm74 761 32 histologic histologic JJ cord-015021-pol2qm74 761 33 study study NN cord-015021-pol2qm74 761 34 with with IN cord-015021-pol2qm74 761 35 light light JJ cord-015021-pol2qm74 761 36 and and CC cord-015021-pol2qm74 761 37 scanning scanning NN cord-015021-pol2qm74 761 38 electron electron NN cord-015021-pol2qm74 761 39 microscopy microscopy NNS cord-015021-pol2qm74 761 40 were be VBD cord-015021-pol2qm74 761 41 taken take VBN cord-015021-pol2qm74 761 42 from from IN cord-015021-pol2qm74 761 43 jejunum jejunum NN cord-015021-pol2qm74 761 44 , , , cord-015021-pol2qm74 761 45 ileum ileum NN cord-015021-pol2qm74 761 46 , , , cord-015021-pol2qm74 761 47 and and CC cord-015021-pol2qm74 761 48 colon colon NN cord-015021-pol2qm74 761 49 . . . cord-015021-pol2qm74 762 1 Animals animal NNS cord-015021-pol2qm74 762 2 were be VBD cord-015021-pol2qm74 762 3 then then RB cord-015021-pol2qm74 762 4 euthanized euthanize VBN cord-015021-pol2qm74 762 5 . . . cord-015021-pol2qm74 763 1 RESULTS result NNS cord-015021-pol2qm74 763 2 : : : cord-015021-pol2qm74 764 1 significant significant JJ cord-015021-pol2qm74 764 2 shock shock NN cord-015021-pol2qm74 764 3 was be VBD cord-015021-pol2qm74 764 4 induced induce VBN cord-015021-pol2qm74 764 5 as as IN cord-015021-pol2qm74 764 6 indicated indicate VBN cord-015021-pol2qm74 764 7 by by IN cord-015021-pol2qm74 764 8 MAP map NN cord-015021-pol2qm74 764 9 and and CC cord-015021-pol2qm74 764 10 arterial arterial JJ cord-015021-pol2qm74 764 11 blood blood NN cord-015021-pol2qm74 764 12 gases gas NNS cord-015021-pol2qm74 764 13 . . . cord-015021-pol2qm74 765 1 Significant significant JJ cord-015021-pol2qm74 765 2 BT BT NNP cord-015021-pol2qm74 765 3 to to IN cord-015021-pol2qm74 765 4 MIN MIN NNP cord-015021-pol2qm74 765 5 was be VBD cord-015021-pol2qm74 765 6 observed observe VBN cord-015021-pol2qm74 765 7 in in IN cord-015021-pol2qm74 765 8 all all DT cord-015021-pol2qm74 765 9 groups group NNS cord-015021-pol2qm74 765 10 . . . cord-015021-pol2qm74 766 1 No no DT cord-015021-pol2qm74 766 2 significant significant JJ cord-015021-pol2qm74 766 3 BT BT NNP cord-015021-pol2qm74 766 4 was be VBD cord-015021-pol2qm74 766 5 observed observe VBN cord-015021-pol2qm74 766 6 in in IN cord-015021-pol2qm74 766 7 cultures culture NNS cord-015021-pol2qm74 766 8 from from IN cord-015021-pol2qm74 766 9 liver liver NN cord-015021-pol2qm74 766 10 and and CC cord-015021-pol2qm74 766 11 spleen spleen NNS cord-015021-pol2qm74 766 12 in in IN cord-015021-pol2qm74 766 13 any any DT cord-015021-pol2qm74 766 14 of of IN cord-015021-pol2qm74 766 15 the the DT cord-015021-pol2qm74 766 16 groups group NNS cord-015021-pol2qm74 766 17 . . . cord-015021-pol2qm74 767 1 Increased increase VBN cord-015021-pol2qm74 767 2 values value NNS cord-015021-pol2qm74 767 3 for for IN cord-015021-pol2qm74 767 4 LTB4 LTB4 NNP cord-015021-pol2qm74 767 5 , , , cord-015021-pol2qm74 767 6 PGE2 PGE2 NNP cord-015021-pol2qm74 767 7 and and CC cord-015021-pol2qm74 767 8 NO no DT cord-015021-pol2qm74 767 9 metabolites metabolite NNS cord-015021-pol2qm74 767 10 were be VBD cord-015021-pol2qm74 767 11 found find VBN cord-015021-pol2qm74 767 12 during during IN cord-015021-pol2qm74 767 13 the the DT cord-015021-pol2qm74 767 14 period period NN cord-015021-pol2qm74 767 15 of of IN cord-015021-pol2qm74 767 16 shock shock NN cord-015021-pol2qm74 767 17 . . . cord-015021-pol2qm74 768 1 These these DT cord-015021-pol2qm74 768 2 results result NNS cord-015021-pol2qm74 768 3 suggest suggest VBP cord-015021-pol2qm74 768 4 that that IN cord-015021-pol2qm74 768 5 the the DT cord-015021-pol2qm74 768 6 isehemic isehemic JJ cord-015021-pol2qm74 768 7 phenomenon phenomenon NN cord-015021-pol2qm74 768 8 triggers trigger VBZ cord-015021-pol2qm74 768 9 a a DT cord-015021-pol2qm74 768 10 significant significant JJ cord-015021-pol2qm74 768 11 inflammatory inflammatory JJ cord-015021-pol2qm74 768 12 response response NN cord-015021-pol2qm74 768 13 , , , cord-015021-pol2qm74 768 14 and and CC cord-015021-pol2qm74 768 15 that that IN cord-015021-pol2qm74 768 16 BT BT NNP cord-015021-pol2qm74 768 17 to to IN cord-015021-pol2qm74 768 18 MIN MIN NNP cord-015021-pol2qm74 768 19 may may MD cord-015021-pol2qm74 768 20 be be VB cord-015021-pol2qm74 768 21 an an DT cord-015021-pol2qm74 768 22 epiphenomenon epiphenomenon NN cord-015021-pol2qm74 768 23 without without IN cord-015021-pol2qm74 768 24 apparent apparent JJ cord-015021-pol2qm74 768 25 significant significant JJ cord-015021-pol2qm74 768 26 influence influence NN cord-015021-pol2qm74 768 27 on on IN cord-015021-pol2qm74 768 28 the the DT cord-015021-pol2qm74 768 29 inflammatory inflammatory JJ cord-015021-pol2qm74 768 30 response response NN cord-015021-pol2qm74 768 31 . . . cord-015021-pol2qm74 769 1 Objective objective NN cord-015021-pol2qm74 769 2 : : : cord-015021-pol2qm74 769 3 To to TO cord-015021-pol2qm74 769 4 study study VB cord-015021-pol2qm74 769 5 the the DT cord-015021-pol2qm74 769 6 potential potential JJ cord-015021-pol2qm74 769 7 effects effect NNS cord-015021-pol2qm74 769 8 and and CC cord-015021-pol2qm74 769 9 mechanisms mechanism NNS cord-015021-pol2qm74 769 10 of of IN cord-015021-pol2qm74 769 11 action action NN cord-015021-pol2qm74 769 12 of of IN cord-015021-pol2qm74 769 13 systemic systemic JJ cord-015021-pol2qm74 769 14 administration administration NN cord-015021-pol2qm74 769 15 of of IN cord-015021-pol2qm74 769 16 monoclonal monoclonal JJ cord-015021-pol2qm74 769 17 antibodies antibody NNS cord-015021-pol2qm74 769 18 anti anti JJ cord-015021-pol2qm74 769 19 - - JJ cord-015021-pol2qm74 769 20 endotoxin endotoxin JJ cord-015021-pol2qm74 769 21 ( ( -LRB- cord-015021-pol2qm74 769 22 HA-1A HA-1A NNP cord-015021-pol2qm74 769 23 ) ) -RRB- cord-015021-pol2qm74 769 24 in in IN cord-015021-pol2qm74 769 25 a a DT cord-015021-pol2qm74 769 26 animal animal NN cord-015021-pol2qm74 769 27 model model NN cord-015021-pol2qm74 769 28 of of IN cord-015021-pol2qm74 769 29 gut gut NN cord-015021-pol2qm74 769 30 - - HYPH cord-015021-pol2qm74 769 31 origin origin NN cord-015021-pol2qm74 769 32 sepsis sepsis NN cord-015021-pol2qm74 769 33 . . . cord-015021-pol2qm74 770 1 Materials material NNS cord-015021-pol2qm74 770 2 and and CC cord-015021-pol2qm74 770 3 Methods method NNS cord-015021-pol2qm74 770 4 : : : cord-015021-pol2qm74 770 5 Exoeriment Exoeriment NNP cord-015021-pol2qm74 770 6 A. a. NN cord-015021-pol2qm74 771 1 BALB BALB NNP cord-015021-pol2qm74 771 2 / / SYM cord-015021-pol2qm74 771 3 c c NN cord-015021-pol2qm74 771 4 mice mouse NNS cord-015021-pol2qm74 771 5 were be VBD cord-015021-pol2qm74 771 6 transfused transfuse VBN cord-015021-pol2qm74 771 7 with with IN cord-015021-pol2qm74 771 8 allogeneic allogeneic NN cord-015021-pol2qm74 771 9 blood blood NN cord-015021-pol2qm74 771 10 ( ( -LRB- cord-015021-pol2qm74 771 11 from from IN cord-015021-pol2qm74 771 12 C3HB C3HB NNP cord-015021-pol2qm74 771 13 - - HYPH cord-015021-pol2qm74 771 14 IeJ IeJ NNP cord-015021-pol2qm74 771 15 mice mouse NNS cord-015021-pol2qm74 771 16 ) ) -RRB- cord-015021-pol2qm74 771 17 . . . cord-015021-pol2qm74 772 1 Five five CD cord-015021-pol2qm74 772 2 days day NNS cord-015021-pol2qm74 772 3 post post NN cord-015021-pol2qm74 772 4 - - JJ cord-015021-pol2qm74 772 5 transfusion transfusion NN cord-015021-pol2qm74 772 6 the the DT cord-015021-pol2qm74 772 7 animals animal NNS cord-015021-pol2qm74 772 8 were be VBD cord-015021-pol2qm74 772 9 gavaged gavage VBN cord-015021-pol2qm74 772 10 with with IN cord-015021-pol2qm74 772 11 lxl09 lxl09 `` cord-015021-pol2qm74 772 12 viable viable JJ cord-015021-pol2qm74 772 13 Escherichia Escherichia NNP cord-015021-pol2qm74 772 14 coil coil NN cord-015021-pol2qm74 772 15 and and CC cord-015021-pol2qm74 772 16 randomized randomize VBD cord-015021-pol2qm74 772 17 into into IN cord-015021-pol2qm74 772 18 3 3 CD cord-015021-pol2qm74 772 19 groups group NNS cord-015021-pol2qm74 772 20 ( ( -LRB- cord-015021-pol2qm74 772 21 n=22 n=22 NNP cord-015021-pol2qm74 772 22 / / SYM cord-015021-pol2qm74 772 23 group group NN cord-015021-pol2qm74 772 24 ) ) -RRB- cord-015021-pol2qm74 772 25 to to TO cord-015021-pol2qm74 772 26 receive receive VB cord-015021-pol2qm74 772 27 a a DT cord-015021-pol2qm74 772 28 sham sham JJ cord-015021-pol2qm74 772 29 burn burn NN cord-015021-pol2qm74 772 30 ( ( -LRB- cord-015021-pol2qm74 772 31 SB SB NNP cord-015021-pol2qm74 772 32 group group NN cord-015021-pol2qm74 772 33 ) ) -RRB- cord-015021-pol2qm74 772 34 or or CC cord-015021-pol2qm74 772 35 a a DT cord-015021-pol2qm74 772 36 20 20 CD cord-015021-pol2qm74 772 37 % % NN cord-015021-pol2qm74 772 38 thermal thermal JJ cord-015021-pol2qm74 772 39 injury injury NN cord-015021-pol2qm74 772 40 immediately immediately RB cord-015021-pol2qm74 772 41 followed follow VBD cord-015021-pol2qm74 772 42 by by IN cord-015021-pol2qm74 772 43 the the DT cord-015021-pol2qm74 772 44 systemic systemic JJ cord-015021-pol2qm74 772 45 administration administration NN cord-015021-pol2qm74 772 46 , , , cord-015021-pol2qm74 772 47 via via IN cord-015021-pol2qm74 772 48 a a DT cord-015021-pol2qm74 772 49 tail tail NN cord-015021-pol2qm74 772 50 vein vein NN cord-015021-pol2qm74 772 51 , , , cord-015021-pol2qm74 772 52 of of IN cord-015021-pol2qm74 772 53 monoclonal monoclonal JJ cord-015021-pol2qm74 772 54 antibodies antibody NNS cord-015021-pol2qm74 772 55 ( ( -LRB- cord-015021-pol2qm74 772 56 6 6 CD cord-015021-pol2qm74 772 57 mg mg NNP cord-015021-pol2qm74 772 58 / / SYM cord-015021-pol2qm74 772 59 kg kg NNP cord-015021-pol2qm74 772 60 ) ) -RRB- cord-015021-pol2qm74 772 61 ( ( -LRB- cord-015021-pol2qm74 772 62 HA-1A HA-1A NNP cord-015021-pol2qm74 772 63 group group NN cord-015021-pol2qm74 772 64 ) ) -RRB- cord-015021-pol2qm74 772 65 or or CC cord-015021-pol2qm74 772 66 a a DT cord-015021-pol2qm74 772 67 20 20 CD cord-015021-pol2qm74 772 68 % % NN cord-015021-pol2qm74 772 69 burn burn NN cord-015021-pol2qm74 772 70 injury injury NN cord-015021-pol2qm74 772 71 and and CC cord-015021-pol2qm74 772 72 administration administration NN cord-015021-pol2qm74 772 73 of of IN cord-015021-pol2qm74 772 74 equal equal JJ cord-015021-pol2qm74 772 75 volume volume NN cord-015021-pol2qm74 772 76 of of IN cord-015021-pol2qm74 772 77 sterile sterile JJ cord-015021-pol2qm74 772 78 saline saline NN cord-015021-pol2qm74 772 79 ( ( -LRB- cord-015021-pol2qm74 772 80 C C NNP cord-015021-pol2qm74 772 81 group group NN cord-015021-pol2qm74 772 82 ) ) -RRB- cord-015021-pol2qm74 772 83 . . . cord-015021-pol2qm74 773 1 All all DT cord-015021-pol2qm74 773 2 3 3 CD cord-015021-pol2qm74 773 3 groups group NNS cord-015021-pol2qm74 773 4 were be VBD cord-015021-pol2qm74 773 5 resuscitated resuscitate VBN cord-015021-pol2qm74 773 6 by by IN cord-015021-pol2qm74 773 7 intraperitoneal intraperitoneal JJ cord-015021-pol2qm74 773 8 injection injection NN cord-015021-pol2qm74 773 9 of of IN cord-015021-pol2qm74 773 10 0.3 0.3 CD cord-015021-pol2qm74 773 11 ml ml NNS cord-015021-pol2qm74 773 12 of of IN cord-015021-pol2qm74 773 13 saline saline NN cord-015021-pol2qm74 773 14 . . . cord-015021-pol2qm74 774 1 The the DT cord-015021-pol2qm74 774 2 animal animal NN cord-015021-pol2qm74 774 3 survival survival NN cord-015021-pol2qm74 774 4 rate rate NN cord-015021-pol2qm74 774 5 was be VBD cord-015021-pol2qm74 774 6 observed observe VBN cord-015021-pol2qm74 774 7 for for IN cord-015021-pol2qm74 774 8 10 10 CD cord-015021-pol2qm74 774 9 days day NNS cord-015021-pol2qm74 774 10 post post NN cord-015021-pol2qm74 774 11 - - JJ cord-015021-pol2qm74 774 12 burn burn JJ cord-015021-pol2qm74 774 13 . . . cord-015021-pol2qm74 775 1 Experiment experiment NN cord-015021-pol2qm74 775 2 B B NNP cord-015021-pol2qm74 775 3 , , , cord-015021-pol2qm74 775 4 Transfusion transfusion NN cord-015021-pol2qm74 775 5 and and CC cord-015021-pol2qm74 775 6 burn burn NN cord-015021-pol2qm74 775 7 procedures procedure NNS cord-015021-pol2qm74 775 8 were be VBD cord-015021-pol2qm74 775 9 identical identical JJ cord-015021-pol2qm74 775 10 to to TO cord-015021-pol2qm74 775 11 experiment experiment VB cord-015021-pol2qm74 775 12 A a DT cord-015021-pol2qm74 776 1 but but CC cord-015021-pol2qm74 776 2 the the DT cord-015021-pol2qm74 776 3 mice mouse NNS cord-015021-pol2qm74 776 4 ( ( -LRB- cord-015021-pol2qm74 776 5 n=8 n=8 NN cord-015021-pol2qm74 776 6 / / SYM cord-015021-pol2qm74 776 7 group group NN cord-015021-pol2qm74 776 8 ) ) -RRB- cord-015021-pol2qm74 776 9 were be VBD cord-015021-pol2qm74 776 10 gavaged gavage VBN cord-015021-pol2qm74 776 11 with with IN cord-015021-pol2qm74 776 12 109 109 CD cord-015021-pol2qm74 776 13 viable viable JJ cord-015021-pol2qm74 776 14 E.coli E.coli NNS cord-015021-pol2qm74 776 15 labeled label VBN cord-015021-pol2qm74 776 16 with with IN cord-015021-pol2qm74 776 17 mMndium mMndium NNP cord-015021-pol2qm74 776 18 oxine oxine NN cord-015021-pol2qm74 776 19 . . . cord-015021-pol2qm74 777 1 Four four CD cord-015021-pol2qm74 777 2 hours hour NNS cord-015021-pol2qm74 777 3 after after IN cord-015021-pol2qm74 777 4 burn burn VBP cord-015021-pol2qm74 777 5 the the DT cord-015021-pol2qm74 777 6 mesenteric mesenteric JJ cord-015021-pol2qm74 777 7 lymph lymph NN cord-015021-pol2qm74 777 8 nodes node NNS cord-015021-pol2qm74 777 9 ( ( -LRB- cord-015021-pol2qm74 777 10 MLN mln NN cord-015021-pol2qm74 777 11 ) ) -RRB- cord-015021-pol2qm74 777 12 , , , cord-015021-pol2qm74 777 13 liver liver NN cord-015021-pol2qm74 777 14 , , , cord-015021-pol2qm74 777 15 lungs lung NNS cord-015021-pol2qm74 777 16 and and CC cord-015021-pol2qm74 777 17 blood blood NN cord-015021-pol2qm74 777 18 were be VBD cord-015021-pol2qm74 777 19 harvested harvest VBN cord-015021-pol2qm74 777 20 to to TO cord-015021-pol2qm74 777 21 determine determine VB cord-015021-pol2qm74 777 22 plasma plasma NN cord-015021-pol2qm74 777 23 endotoxin endotoxin NN cord-015021-pol2qm74 777 24 levels level NNS cord-015021-pol2qm74 777 25 and and CC cord-015021-pol2qm74 777 26 the the DT cord-015021-pol2qm74 777 27 magnitude magnitude NN cord-015021-pol2qm74 777 28 of of IN cord-015021-pol2qm74 777 29 transtocation transtocation NN cord-015021-pol2qm74 777 30 of of IN cord-015021-pol2qm74 777 31 labeled label VBN cord-015021-pol2qm74 777 32 bacteria bacteria NNS cord-015021-pol2qm74 777 33 as as IN cord-015021-pol2qm74 777 34 measured measure VBN cord-015021-pol2qm74 777 35 by by IN cord-015021-pol2qm74 777 36 the the DT cord-015021-pol2qm74 777 37 residual residual JJ cord-015021-pol2qm74 777 38 radioactivity radioactivity NN cord-015021-pol2qm74 777 39 ( ( -LRB- cord-015021-pol2qm74 777 40 dpm dpm NNP cord-015021-pol2qm74 777 41 ) ) -RRB- cord-015021-pol2qm74 777 42 in in IN cord-015021-pol2qm74 777 43 the the DT cord-015021-pol2qm74 777 44 organs organ NNS cord-015021-pol2qm74 777 45 . . . cord-015021-pol2qm74 778 1 Circulating circulate VBG cord-015021-pol2qm74 778 2 endotoxin endotoxin NN cord-015021-pol2qm74 778 3 levels level NNS cord-015021-pol2qm74 778 4 were be VBD cord-015021-pol2qm74 778 5 determined determine VBN cord-015021-pol2qm74 778 6 by by IN cord-015021-pol2qm74 778 7 limulus limulus NNP cord-015021-pol2qm74 778 8 colorimetric colorimetric JJ cord-015021-pol2qm74 778 9 assay assay NN cord-015021-pol2qm74 778 10 . . . cord-015021-pol2qm74 779 1 Diamine diamine NN cord-015021-pol2qm74 779 2 0xidae(DAO 0xidae(DAO . cord-015021-pol2qm74 779 3 ) ) -RRB- cord-015021-pol2qm74 779 4 is be VBZ cord-015021-pol2qm74 779 5 an an DT cord-015021-pol2qm74 779 6 enzyme enzyme NN cord-015021-pol2qm74 779 7 existing exist VBG cord-015021-pol2qm74 779 8 in in IN cord-015021-pol2qm74 779 9 the the DT cord-015021-pol2qm74 779 10 mucosa mucosa NN cord-015021-pol2qm74 779 11 of of IN cord-015021-pol2qm74 779 12 small small JJ cord-015021-pol2qm74 779 13 intestines intestine NNS cord-015021-pol2qm74 779 14 , , , cord-015021-pol2qm74 779 15 but but CC cord-015021-pol2qm74 779 16 its -PRON- PRP$ cord-015021-pol2qm74 779 17 activity activity NN cord-015021-pol2qm74 779 18 is be VBZ cord-015021-pol2qm74 779 19 low low JJ cord-015021-pol2qm74 779 20 in in IN cord-015021-pol2qm74 779 21 the the DT cord-015021-pol2qm74 779 22 plasma plasma NN cord-015021-pol2qm74 779 23 . . . cord-015021-pol2qm74 780 1 It -PRON- PRP cord-015021-pol2qm74 780 2 is be VBZ cord-015021-pol2qm74 780 3 evoked evoke VBN cord-015021-pol2qm74 780 4 in in IN cord-015021-pol2qm74 780 5 the the DT cord-015021-pol2qm74 780 6 blood blood NN cord-015021-pol2qm74 780 7 with with IN cord-015021-pol2qm74 780 8 the the DT cord-015021-pol2qm74 780 9 intravenous intravenous JJ cord-015021-pol2qm74 780 10 injection injection NN cord-015021-pol2qm74 780 11 of of IN cord-015021-pol2qm74 780 12 much much JJ cord-015021-pol2qm74 780 13 heparin heparin NN cord-015021-pol2qm74 780 14 . . . cord-015021-pol2qm74 781 1 It -PRON- PRP cord-015021-pol2qm74 781 2 is be VBZ cord-015021-pol2qm74 781 3 well well RB cord-015021-pol2qm74 781 4 known know VBN cord-015021-pol2qm74 781 5 that that IN cord-015021-pol2qm74 781 6 DA0 da0 NN cord-015021-pol2qm74 781 7 declines decline VBZ cord-015021-pol2qm74 781 8 under under IN cord-015021-pol2qm74 781 9 the the DT cord-015021-pol2qm74 781 10 chronic chronic JJ cord-015021-pol2qm74 781 11 mueosal mueosal NN cord-015021-pol2qm74 781 12 injury injury NN cord-015021-pol2qm74 781 13 when when WRB cord-015021-pol2qm74 781 14 the the DT cord-015021-pol2qm74 781 15 small small JJ cord-015021-pol2qm74 781 16 intestines intestine NNS cord-015021-pol2qm74 781 17 are be VBP cord-015021-pol2qm74 781 18 cut cut VBN cord-015021-pol2qm74 781 19 off off RP cord-015021-pol2qm74 781 20 or or CC cord-015021-pol2qm74 781 21 the the DT cord-015021-pol2qm74 781 22 mucosae mucosae NNP cord-015021-pol2qm74 781 23 become become VBN cord-015021-pol2qm74 781 24 atrophied atrophied JJ cord-015021-pol2qm74 781 25 . . . cord-015021-pol2qm74 782 1 Aim aim VB cord-015021-pol2qm74 782 2 of of IN cord-015021-pol2qm74 782 3 this this DT cord-015021-pol2qm74 782 4 paper paper NN cord-015021-pol2qm74 782 5 is be VBZ cord-015021-pol2qm74 782 6 to to TO cord-015021-pol2qm74 782 7 confirm confirm VB cord-015021-pol2qm74 782 8 that that DT cord-015021-pol2qm74 782 9 DA0 da0 NN cord-015021-pol2qm74 782 10 goes go VBZ cord-015021-pol2qm74 782 11 up up IN cord-015021-pol2qm74 782 12 to to IN cord-015021-pol2qm74 782 13 the the DT cord-015021-pol2qm74 782 14 measureable measureable JJ cord-015021-pol2qm74 782 15 level level NN cord-015021-pol2qm74 782 16 by by IN cord-015021-pol2qm74 782 17 the the DT cord-015021-pol2qm74 782 18 intravenous intravenous JJ cord-015021-pol2qm74 782 19 injection injection NN cord-015021-pol2qm74 782 20 of of IN cord-015021-pol2qm74 782 21 a a DT cord-015021-pol2qm74 782 22 small small JJ cord-015021-pol2qm74 782 23 amounts amount NNS cord-015021-pol2qm74 782 24 of of IN cord-015021-pol2qm74 782 25 low low JJ cord-015021-pol2qm74 782 26 molecular molecular JJ cord-015021-pol2qm74 782 27 heparin(LMH heparin(lmh NN cord-015021-pol2qm74 782 28 Objectives objectives NN cord-015021-pol2qm74 782 29 : : : cord-015021-pol2qm74 782 30 The the DT cord-015021-pol2qm74 782 31 aims aim NNS cord-015021-pol2qm74 782 32 of of IN cord-015021-pol2qm74 782 33 this this DT cord-015021-pol2qm74 782 34 study study NN cord-015021-pol2qm74 782 35 is be VBZ cord-015021-pol2qm74 782 36 to to TO cord-015021-pol2qm74 782 37 investigate investigate VB cord-015021-pol2qm74 782 38 the the DT cord-015021-pol2qm74 782 39 inhibitor inhibitor NN cord-015021-pol2qm74 782 40 " " '' cord-015021-pol2qm74 782 41 effect effect NN cord-015021-pol2qm74 782 42 of of IN cord-015021-pol2qm74 782 43 the the DT cord-015021-pol2qm74 782 44 prolease prolease NN cord-015021-pol2qm74 782 45 inhibitor inhibitor NN cord-015021-pol2qm74 782 46 , , , cord-015021-pol2qm74 782 47 Urinastatin Urinastatin NNP cord-015021-pol2qm74 782 48 , , , cord-015021-pol2qm74 782 49 on on IN cord-015021-pol2qm74 782 50 endotoxin endotoxin NN cord-015021-pol2qm74 782 51 induced induce VBN cord-015021-pol2qm74 782 52 bacterial bacterial JJ cord-015021-pol2qm74 782 53 transleeation transleeation NN cord-015021-pol2qm74 782 54 in in IN cord-015021-pol2qm74 782 55 mice mouse NNS cord-015021-pol2qm74 782 56 . . . cord-015021-pol2qm74 783 1 Materials material NNS cord-015021-pol2qm74 783 2 and and CC cord-015021-pol2qm74 783 3 methods method NNS cord-015021-pol2qm74 783 4 : : : cord-015021-pol2qm74 783 5 lCR lcr NN cord-015021-pol2qm74 783 6 mice mouse NNS cord-015021-pol2qm74 783 7 were be VBD cord-015021-pol2qm74 783 8 divided divide VBN cord-015021-pol2qm74 783 9 in in IN cord-015021-pol2qm74 783 10 six six CD cord-015021-pol2qm74 783 11 groups group NNS cord-015021-pol2qm74 783 12 as as IN cord-015021-pol2qm74 783 13 the the DT cord-015021-pol2qm74 783 14 fotlows fotlow NNS cord-015021-pol2qm74 783 15 , , , cord-015021-pol2qm74 783 16 Group Group NNP cord-015021-pol2qm74 783 17 I i NN cord-015021-pol2qm74 783 18 : : : cord-015021-pol2qm74 783 19 Control control NN cord-015021-pol2qm74 783 20 mice mouse NNS cord-015021-pol2qm74 783 21 receiving receive VBG cord-015021-pol2qm74 783 22 intraperitoneal intraperitoneal JJ cord-015021-pol2qm74 783 23 injections injection NNS cord-015021-pol2qm74 783 24 ( ( -LRB- cord-015021-pol2qm74 783 25 IP IP NNP cord-015021-pol2qm74 783 26 ) ) -RRB- cord-015021-pol2qm74 783 27 of of IN cord-015021-pol2qm74 783 28 saline saline NN cord-015021-pol2qm74 783 29 24.5 24.5 CD cord-015021-pol2qm74 783 30 and and CC cord-015021-pol2qm74 783 31 24 24 CD cord-015021-pol2qm74 783 32 hr hr NN cord-015021-pol2qm74 783 33 prior prior RB cord-015021-pol2qm74 783 34 to to IN cord-015021-pol2qm74 783 35 sacrifice sacrifice NN cord-015021-pol2qm74 783 36 , , , cord-015021-pol2qm74 783 37 Group Group NNP cord-015021-pol2qm74 783 38 Ih Ih NNP cord-015021-pol2qm74 783 39 Treated treat VBD cord-015021-pol2qm74 783 40 mice mouse NNS cord-015021-pol2qm74 783 41 receiving receive VBG cord-015021-pol2qm74 783 42 IP ip NN cord-015021-pol2qm74 783 43 of of IN cord-015021-pol2qm74 783 44 Utinastatin Utinastatin NNP cord-015021-pol2qm74 783 45 24.5 24.5 CD cord-015021-pol2qm74 783 46 hr hr NN cord-015021-pol2qm74 783 47 and and CC cord-015021-pol2qm74 783 48 endotoxin endotoxin NN cord-015021-pol2qm74 783 49 ( ( -LRB- cord-015021-pol2qm74 783 50 5mg 5mg NNP cord-015021-pol2qm74 783 51 / / SYM cord-015021-pol2qm74 783 52 kg kg NN cord-015021-pol2qm74 783 53 ) ) -RRB- cord-015021-pol2qm74 784 1 24hr 24hr JJ cord-015021-pol2qm74 784 2 prior prior RB cord-015021-pol2qm74 784 3 to to IN cord-015021-pol2qm74 784 4 sacrifice sacrifice NN cord-015021-pol2qm74 784 5 , , , cord-015021-pol2qm74 784 6 Group Group NNP cord-015021-pol2qm74 784 7 Ilk Ilk NNP cord-015021-pol2qm74 784 8 Sham4reated Sham4reated NNP cord-015021-pol2qm74 784 9 mice mouse NNS cord-015021-pol2qm74 784 10 receiving receive VBG cord-015021-pol2qm74 784 11 IP ip NN cord-015021-pol2qm74 784 12 of of IN cord-015021-pol2qm74 784 13 saline saline NN cord-015021-pol2qm74 784 14 24.5 24.5 CD cord-015021-pol2qm74 784 15 hr hr NN cord-015021-pol2qm74 784 16 and and CC cord-015021-pol2qm74 784 17 endotoxin endotoxin NN cord-015021-pol2qm74 784 18 ( ( -LRB- cord-015021-pol2qm74 784 19 5mg 5mg NNP cord-015021-pol2qm74 784 20 / / SYM cord-015021-pol2qm74 784 21 kg kg NN cord-015021-pol2qm74 785 1 ) ) -RRB- cord-015021-pol2qm74 785 2 24hr 24hr RB cord-015021-pol2qm74 785 3 prior prior RB cord-015021-pol2qm74 785 4 to to IN cord-015021-pol2qm74 785 5 sacrifice sacrifice NN cord-015021-pol2qm74 785 6 , , , cord-015021-pol2qm74 785 7 Group Group NNP cord-015021-pol2qm74 785 8 IV IV NNP cord-015021-pol2qm74 785 9 : : : cord-015021-pol2qm74 785 10 saline saline NN cord-015021-pol2qm74 785 11 control control NN cord-015021-pol2qm74 785 12 mice mouse NNS cord-015021-pol2qm74 785 13 receiving receive VBG cord-015021-pol2qm74 785 14 IP ip NN cord-015021-pol2qm74 785 15 twice twice RB cord-015021-pol2qm74 785 16 during during IN cord-015021-pol2qm74 785 17 30 30 CD cord-015021-pol2qm74 785 18 rain rain NN cord-015021-pol2qm74 785 19 intervals interval NNS cord-015021-pol2qm74 785 20 , , , cord-015021-pol2qm74 785 21 Group Group NNP cord-015021-pol2qm74 785 22 V v NN cord-015021-pol2qm74 785 23 : : : cord-015021-pol2qm74 785 24 Mice mouse NNS cord-015021-pol2qm74 785 25 received receive VBD cord-015021-pol2qm74 785 26 IP ip NN cord-015021-pol2qm74 785 27 of of IN cord-015021-pol2qm74 785 28 Utinasmtin Utinasmtin NNP cord-015021-pol2qm74 785 29 , , , cord-015021-pol2qm74 785 30 and and CC cord-015021-pol2qm74 785 31 30 30 CD cord-015021-pol2qm74 785 32 min min NN cord-015021-pol2qm74 785 33 later later RB cord-015021-pol2qm74 785 34 they -PRON- PRP cord-015021-pol2qm74 785 35 were be VBD cord-015021-pol2qm74 785 36 received receive VBN cord-015021-pol2qm74 785 37 IP ip NN cord-015021-pol2qm74 785 38 of of IN cord-015021-pol2qm74 785 39 endotoxin endotoxin NN cord-015021-pol2qm74 785 40 ( ( -LRB- cord-015021-pol2qm74 785 41 5mg 5mg NNP cord-015021-pol2qm74 785 42 / / SYM cord-015021-pol2qm74 785 43 kg kg NNP cord-015021-pol2qm74 785 44 ) ) -RRB- cord-015021-pol2qm74 785 45 , , , cord-015021-pol2qm74 785 46 Group Group NNP cord-015021-pol2qm74 785 47 VI VI NNP cord-015021-pol2qm74 785 48 : : : cord-015021-pol2qm74 786 1 Mice mouse NNS cord-015021-pol2qm74 786 2 received receive VBD cord-015021-pol2qm74 786 3 IP ip NN cord-015021-pol2qm74 786 4 of of IN cord-015021-pol2qm74 786 5 saline saline NN cord-015021-pol2qm74 786 6 , , , cord-015021-pol2qm74 786 7 and and CC cord-015021-pol2qm74 786 8 30 30 CD cord-015021-pol2qm74 786 9 min min NN cord-015021-pol2qm74 786 10 later later RBR cord-015021-pol2qm74 786 11 they -PRON- PRP cord-015021-pol2qm74 786 12 received receive VBD cord-015021-pol2qm74 786 13 IP ip NN cord-015021-pol2qm74 786 14 of of IN cord-015021-pol2qm74 786 15 endotoxin endotoxin NN cord-015021-pol2qm74 786 16 ( ( -LRB- cord-015021-pol2qm74 786 17 5mg 5mg NNP cord-015021-pol2qm74 786 18 / / SYM cord-015021-pol2qm74 786 19 kg kg NNP cord-015021-pol2qm74 786 20 ) ) -RRB- cord-015021-pol2qm74 786 21 . . . cord-015021-pol2qm74 787 1 In in IN cord-015021-pol2qm74 787 2 group group NN cord-015021-pol2qm74 787 3 l l NN cord-015021-pol2qm74 787 4 , , , cord-015021-pol2qm74 787 5 II II NNP cord-015021-pol2qm74 787 6 and and CC cord-015021-pol2qm74 787 7 Ill Ill NNP cord-015021-pol2qm74 787 8 , , , cord-015021-pol2qm74 787 9 the the DT cord-015021-pol2qm74 787 10 mice mouse NNS cord-015021-pol2qm74 787 11 were be VBD cord-015021-pol2qm74 787 12 killed kill VBN cord-015021-pol2qm74 787 13 by by IN cord-015021-pol2qm74 787 14 cervical cervical JJ cord-015021-pol2qm74 787 15 dislocation dislocation NN cord-015021-pol2qm74 787 16 . . . cord-015021-pol2qm74 788 1 Using use VBG cord-015021-pol2qm74 788 2 stetile stetile JJ cord-015021-pol2qm74 788 3 techniques technique NNS cord-015021-pol2qm74 788 4 , , , cord-015021-pol2qm74 788 5 a a DT cord-015021-pol2qm74 788 6 middle middle JJ cord-015021-pol2qm74 788 7 - - HYPH cord-015021-pol2qm74 788 8 line line NN cord-015021-pol2qm74 788 9 incision incision NN cord-015021-pol2qm74 788 10 was be VBD cord-015021-pol2qm74 788 11 made make VBN cord-015021-pol2qm74 788 12 and and CC cord-015021-pol2qm74 788 13 the the DT cord-015021-pol2qm74 788 14 mesenteric mesenteric JJ cord-015021-pol2qm74 788 15 lymph lymph NN cord-015021-pol2qm74 788 16 nodes node NNS cord-015021-pol2qm74 788 17 were be VBD cord-015021-pol2qm74 788 18 harvested harvest VBN cord-015021-pol2qm74 788 19 in in IN cord-015021-pol2qm74 788 20 order order NN cord-015021-pol2qm74 788 21 to to IN cord-015021-pol2qm74 788 22 culture culture NN cord-015021-pol2qm74 788 23 on on IN cord-015021-pol2qm74 788 24 selective selective JJ cord-015021-pol2qm74 788 25 agars agar NNS cord-015021-pol2qm74 788 26 for for IN cord-015021-pol2qm74 788 27 quantitation quantitation NN cord-015021-pol2qm74 788 28 of of IN cord-015021-pol2qm74 788 29 bacterial bacterial JJ cord-015021-pol2qm74 788 30 trauslocation trauslocation NN cord-015021-pol2qm74 788 31 . . . cord-015021-pol2qm74 789 1 In in IN cord-015021-pol2qm74 789 2 group group NN cord-015021-pol2qm74 789 3 IV IV NNP cord-015021-pol2qm74 789 4 , , , cord-015021-pol2qm74 789 5 V v NN cord-015021-pol2qm74 789 6 and and CC cord-015021-pol2qm74 789 7 VI VI NNP cord-015021-pol2qm74 789 8 , , , cord-015021-pol2qm74 789 9 survival survival NN cord-015021-pol2qm74 789 10 was be VBD cord-015021-pol2qm74 789 11 recorded record VBN cord-015021-pol2qm74 789 12 for for IN cord-015021-pol2qm74 789 13 3 3 CD cord-015021-pol2qm74 789 14 days day NNS cord-015021-pol2qm74 789 15 . . . cord-015021-pol2qm74 790 1 Unnastatin Unnastatin NNP cord-015021-pol2qm74 790 2 pretreatment pretreatment NN cord-015021-pol2qm74 790 3 could could MD cord-015021-pol2qm74 790 4 rednce rednce VB cord-015021-pol2qm74 790 5 mortality mortality NN cord-015021-pol2qm74 790 6 significantly significantly RB cord-015021-pol2qm74 790 7 . . . cord-015021-pol2qm74 791 1 First first JJ cord-015021-pol2qm74 791 2 surgey surgey NN cord-015021-pol2qm74 791 3 , , , cord-015021-pol2qm74 791 4 Shiga Shiga NNP cord-015021-pol2qm74 791 5 university university NNP cord-015021-pol2qm74 791 6 of of IN cord-015021-pol2qm74 791 7 medical medical JJ cord-015021-pol2qm74 791 8 science science NN cord-015021-pol2qm74 791 9 , , , cord-015021-pol2qm74 791 10 Seta Seta NNP cord-015021-pol2qm74 791 11 , , , cord-015021-pol2qm74 791 12 Ohtsu Ohtsu NNP cord-015021-pol2qm74 791 13 520 520 CD cord-015021-pol2qm74 791 14 - - HYPH cord-015021-pol2qm74 791 15 21,Japan 21,japan JJ cord-015021-pol2qm74 791 16 Increased increase VBN cord-015021-pol2qm74 791 17 gut gut NN cord-015021-pol2qm74 791 18 permeability permeability NN cord-015021-pol2qm74 791 19 correlates correlate VBZ cord-015021-pol2qm74 791 20 with with IN cord-015021-pol2qm74 791 21 inflammatory inflammatory JJ cord-015021-pol2qm74 791 22 response response NN cord-015021-pol2qm74 791 23 in in IN cord-015021-pol2qm74 791 24 multiple multiple JJ cord-015021-pol2qm74 791 25 trauma trauma NN cord-015021-pol2qm74 791 26 aptients aptient NNS cord-015021-pol2qm74 791 27 . . . cord-015021-pol2qm74 792 1 Pape Pape NNP cord-015021-pol2qm74 792 2 , , , cord-015021-pol2qm74 792 3 H.-C. H.-C. NNP cord-015021-pol2qm74 792 4 Dwenger Dwenger NNP cord-015021-pol2qm74 792 5 , , , cord-015021-pol2qm74 792 6 A. A. NNP cord-015021-pol2qm74 792 7 Grotz Grotz NNP cord-015021-pol2qm74 792 8 , , , cord-015021-pol2qm74 792 9 M. M. NNP cord-015021-pol2qm74 792 10 Regel Regel NNP cord-015021-pol2qm74 792 11 , , , cord-015021-pol2qm74 792 12 G. G. NNP cord-015021-pol2qm74 792 13 PURPOSE purpose NN cord-015021-pol2qm74 792 14 : : : cord-015021-pol2qm74 793 1 Disturbances disturbance NNS cord-015021-pol2qm74 793 2 of of IN cord-015021-pol2qm74 793 3 intestinal intestinal JJ cord-015021-pol2qm74 793 4 permeability permeability NN cord-015021-pol2qm74 793 5 have have VBP cord-015021-pol2qm74 793 6 been be VBN cord-015021-pol2qm74 793 7 advocated advocate VBN cord-015021-pol2qm74 793 8 as as IN cord-015021-pol2qm74 793 9 a a DT cord-015021-pol2qm74 793 10 pathogenetic pathogenetic JJ cord-015021-pol2qm74 793 11 factor factor NN cord-015021-pol2qm74 793 12 of of IN cord-015021-pol2qm74 793 13 posttranmatic posttranmatic JJ cord-015021-pol2qm74 793 14 multisystem multisystem JJ cord-015021-pol2qm74 793 15 organ organ NN cord-015021-pol2qm74 793 16 failure failure NN cord-015021-pol2qm74 793 17 ( ( -LRB- cord-015021-pol2qm74 793 18 MOF MOF NNP cord-015021-pol2qm74 793 19 ) ) -RRB- cord-015021-pol2qm74 793 20 . . . cord-015021-pol2qm74 794 1 A a DT cord-015021-pol2qm74 794 2 close close JJ cord-015021-pol2qm74 794 3 relationship relationship NN cord-015021-pol2qm74 794 4 with with IN cord-015021-pol2qm74 794 5 impairment impairment NN cord-015021-pol2qm74 794 6 of of IN cord-015021-pol2qm74 794 7 the the DT cord-015021-pol2qm74 794 8 stationary stationary JJ cord-015021-pol2qm74 794 9 reticulocndothelial reticulocndothelial JJ cord-015021-pol2qm74 794 10 system system NN cord-015021-pol2qm74 794 11 ( ( -LRB- cord-015021-pol2qm74 794 12 RES RES NNP cord-015021-pol2qm74 794 13 ) ) -RRB- cord-015021-pol2qm74 794 14 and and CC cord-015021-pol2qm74 794 15 a a DT cord-015021-pol2qm74 794 16 systemic systemic JJ cord-015021-pol2qm74 794 17 inflammatory inflammatory JJ cord-015021-pol2qm74 794 18 response response NN cord-015021-pol2qm74 794 19 ( ( -LRB- cord-015021-pol2qm74 794 20 SIR SIR NNP cord-015021-pol2qm74 794 21 ) ) -RRB- cord-015021-pol2qm74 794 22 was be VBD cord-015021-pol2qm74 794 23 discussed discuss VBN cord-015021-pol2qm74 794 24 . . . cord-015021-pol2qm74 795 1 These these DT cord-015021-pol2qm74 795 2 tactors tactor NNS cord-015021-pol2qm74 795 3 were be VBD cord-015021-pol2qm74 795 4 investigated investigate VBN cord-015021-pol2qm74 795 5 prospectively prospectively RB cord-015021-pol2qm74 795 6 in in IN cord-015021-pol2qm74 795 7 patients patient NNS cord-015021-pol2qm74 795 8 with with IN cord-015021-pol2qm74 795 9 multiple multiple JJ cord-015021-pol2qm74 795 10 trauma trauma NN cord-015021-pol2qm74 795 11 showing show VBG cord-015021-pol2qm74 795 12 posttraumatie posttraumatie NN cord-015021-pol2qm74 795 13 complications complication NNS cord-015021-pol2qm74 795 14 ( ( -LRB- cord-015021-pol2qm74 795 15 multiple multiple JJ cord-015021-pol2qm74 795 16 organ organ NN cord-015021-pol2qm74 795 17 failure failure NN cord-015021-pol2qm74 795 18 , , , cord-015021-pol2qm74 795 19 MOF MOF NNP cord-015021-pol2qm74 795 20 ) ) -RRB- cord-015021-pol2qm74 795 21 . . . cord-015021-pol2qm74 796 1 METHODS method NNS cord-015021-pol2qm74 796 2 : : : cord-015021-pol2qm74 796 3 31 31 CD cord-015021-pol2qm74 796 4 polytranmatized polytranmatize VBN cord-015021-pol2qm74 796 5 patients patient NNS cord-015021-pol2qm74 796 6 were be VBD cord-015021-pol2qm74 796 7 studied study VBN cord-015021-pol2qm74 796 8 prospectively prospectively RB cord-015021-pol2qm74 796 9 . . . cord-015021-pol2qm74 797 1 According accord VBG cord-015021-pol2qm74 797 2 to to IN cord-015021-pol2qm74 797 3 a a DT cord-015021-pol2qm74 797 4 MOF MOF NNP cord-015021-pol2qm74 797 5 - - HYPH cord-015021-pol2qm74 797 6 score score NN cord-015021-pol2qm74 797 7 ( ( -LRB- cord-015021-pol2qm74 797 8 GORIS GORIS NNP cord-015021-pol2qm74 797 9 ) ) -RRB- cord-015021-pol2qm74 798 1 those those DT cord-015021-pol2qm74 798 2 with with IN cord-015021-pol2qm74 798 3 posttrattmatic posttrattmatic JJ cord-015021-pol2qm74 798 4 complications complication NNS cord-015021-pol2qm74 798 5 were be VBD cord-015021-pol2qm74 798 6 selected select VBN cord-015021-pol2qm74 798 7 ( ( -LRB- cord-015021-pol2qm74 798 8 > > NFP cord-015021-pol2qm74 798 9 7 7 CD cord-015021-pol2qm74 798 10 points point NNS cord-015021-pol2qm74 798 11 at at IN cord-015021-pol2qm74 798 12 2 2 CD cord-015021-pol2qm74 798 13 days day NNS cord-015021-pol2qm74 798 14 ) ) -RRB- cord-015021-pol2qm74 798 15 , , , cord-015021-pol2qm74 798 16 others other NNS cord-015021-pol2qm74 798 17 were be VBD cord-015021-pol2qm74 798 18 excluded exclude VBN cord-015021-pol2qm74 798 19 . . . cord-015021-pol2qm74 799 1 Every every DT cord-015021-pol2qm74 799 2 second second JJ cord-015021-pol2qm74 799 3 day day NN cord-015021-pol2qm74 799 4 gut gut NN cord-015021-pol2qm74 799 5 permeability permeability NN cord-015021-pol2qm74 799 6 according accord VBG cord-015021-pol2qm74 799 7 to to IN cord-015021-pol2qm74 799 8 the the DT cord-015021-pol2qm74 799 9 ratio ratio NN cord-015021-pol2qm74 799 10 of of IN cord-015021-pol2qm74 799 11 urine urine NN cord-015021-pol2qm74 799 12 concentrations concentration NNS cord-015021-pol2qm74 799 13 of of IN cord-015021-pol2qm74 799 14 lactulose lactulose NN cord-015021-pol2qm74 799 15 and and CC cord-015021-pol2qm74 799 16 mannitol mannitol NN cord-015021-pol2qm74 799 17 ( ( -LRB- cord-015021-pol2qm74 799 18 L L NNP cord-015021-pol2qm74 799 19 / / SYM cord-015021-pol2qm74 799 20 M M NNP cord-015021-pol2qm74 799 21 ) ) -RRB- cord-015021-pol2qm74 799 22 was be VBD cord-015021-pol2qm74 799 23 evaluated evaluate VBN cord-015021-pol2qm74 799 24 ( ( -LRB- cord-015021-pol2qm74 799 25 enteral enteral JJ cord-015021-pol2qm74 799 26 application application NN cord-015021-pol2qm74 799 27 ) ) -RRB- cord-015021-pol2qm74 799 28 . . . cord-015021-pol2qm74 800 1 At at IN cord-015021-pol2qm74 800 2 parallel parallel JJ cord-015021-pol2qm74 800 3 time time NN cord-015021-pol2qm74 800 4 points point NNS cord-015021-pol2qm74 800 5 RES res NN cord-015021-pol2qm74 800 6 clearance clearance NN cord-015021-pol2qm74 800 7 capacity capacity NN cord-015021-pol2qm74 800 8 ( ( -LRB- cord-015021-pol2qm74 800 9 K k NN cord-015021-pol2qm74 800 10 - - HYPH cord-015021-pol2qm74 800 11 value value NN cord-015021-pol2qm74 800 12 , , , cord-015021-pol2qm74 800 13 invasion invasion NN cord-015021-pol2qm74 800 14 constant constant JJ cord-015021-pol2qm74 800 15 , , , cord-015021-pol2qm74 800 16 normal normal JJ cord-015021-pol2qm74 800 17 range range NN cord-015021-pol2qm74 800 18 0.6 0.6 CD cord-015021-pol2qm74 800 19 -0.8 -0.8 NN cord-015021-pol2qm74 800 20 mind mind NN cord-015021-pol2qm74 800 21 ) ) -RRB- cord-015021-pol2qm74 800 22 was be VBD cord-015021-pol2qm74 800 23 studied study VBN cord-015021-pol2qm74 800 24 after after IN cord-015021-pol2qm74 800 25 i.v i.v NNP cord-015021-pol2qm74 800 26 . . NNP cord-015021-pol2qm74 800 27 injection injection NN cord-015021-pol2qm74 800 28 of of IN cord-015021-pol2qm74 800 29 100 100 CD cord-015021-pol2qm74 800 30 mBq mBq NNS cord-015021-pol2qm74 800 31 99roTehuman 99rotehuman CD cord-015021-pol2qm74 800 32 albumin albumin NN cord-015021-pol2qm74 800 33 . . . cord-015021-pol2qm74 801 1 Liver liver NN cord-015021-pol2qm74 801 2 perfusion perfusion NN cord-015021-pol2qm74 801 3 was be VBD cord-015021-pol2qm74 801 4 calculated calculate VBN cord-015021-pol2qm74 801 5 from from IN cord-015021-pol2qm74 801 6 these these DT cord-015021-pol2qm74 801 7 data datum NNS cord-015021-pol2qm74 801 8 , , , cord-015021-pol2qm74 801 9 total total JJ cord-015021-pol2qm74 801 10 serum serum NN cord-015021-pol2qm74 801 11 bilirubin bilirubin NN cord-015021-pol2qm74 801 12 ( ( -LRB- cord-015021-pol2qm74 801 13 /zmol /zmol NNP cord-015021-pol2qm74 801 14 / / SYM cord-015021-pol2qm74 801 15 l l NN cord-015021-pol2qm74 801 16 ) ) -RRB- cord-015021-pol2qm74 801 17 was be VBD cord-015021-pol2qm74 801 18 documented document VBN cord-015021-pol2qm74 801 19 . . . cord-015021-pol2qm74 802 1 Serum serum NN cord-015021-pol2qm74 802 2 elastase elastase NN cord-015021-pol2qm74 802 3 ( ( -LRB- cord-015021-pol2qm74 802 4 # # $ cord-015021-pol2qm74 802 5 g g NN cord-015021-pol2qm74 802 6 / / SYM cord-015021-pol2qm74 802 7 l l NN cord-015021-pol2qm74 802 8 ) ) -RRB- cord-015021-pol2qm74 802 9 levels level NNS cord-015021-pol2qm74 802 10 were be VBD cord-015021-pol2qm74 802 11 determined determine VBN cord-015021-pol2qm74 802 12 enzymatieally enzymatieally RB cord-015021-pol2qm74 802 13 . . . cord-015021-pol2qm74 803 1 RESULTS result NNS cord-015021-pol2qm74 803 2 86.0 86.0 CD cord-015021-pol2qm74 803 3 148 148 CD cord-015021-pol2qm74 803 4 + + SYM cord-015021-pol2qm74 803 5 239 239 CD cord-015021-pol2qm74 804 1 + + CC cord-015021-pol2qm74 804 2 Liver liver NN cord-015021-pol2qm74 804 3 perfusion perfusion NN cord-015021-pol2qm74 804 4 did do VBD cord-015021-pol2qm74 804 5 not not RB cord-015021-pol2qm74 804 6 ehangu ehangu NNP cord-015021-pol2qm74 805 1 , , , cord-015021-pol2qm74 805 2 bilirubin bilirubin NN cord-015021-pol2qm74 805 3 showed show VBD cord-015021-pol2qm74 805 4 progressive progressive JJ cord-015021-pol2qm74 805 5 worsening worsen VBG cord-015021-pol2qm74 805 6 indicating indicate VBG cord-015021-pol2qm74 805 7 MOF MOF NNP cord-015021-pol2qm74 805 8 . . . cord-015021-pol2qm74 806 1 A a DT cord-015021-pol2qm74 806 2 positive positive JJ cord-015021-pol2qm74 806 3 correlation correlation NN cord-015021-pol2qm74 806 4 was be VBD cord-015021-pol2qm74 806 5 present present JJ cord-015021-pol2qm74 806 6 between between IN cord-015021-pol2qm74 806 7 L L NNP cord-015021-pol2qm74 806 8 / / SYM cord-015021-pol2qm74 806 9 m m NN cord-015021-pol2qm74 806 10 and and CC cord-015021-pol2qm74 806 11 K K NNP cord-015021-pol2qm74 806 12 ( ( -LRB- cord-015021-pol2qm74 806 13 r=0.88 r=0.88 NNP cord-015021-pol2qm74 806 14 ) ) -RRB- cord-015021-pol2qm74 806 15 and and CC cord-015021-pol2qm74 806 16 between between IN cord-015021-pol2qm74 806 17 L L NNP cord-015021-pol2qm74 806 18 / / SYM cord-015021-pol2qm74 806 19 m m NNP cord-015021-pol2qm74 806 20 and and CC cord-015021-pol2qm74 806 21 Ela Ela NNP cord-015021-pol2qm74 806 22 ( ( -LRB- cord-015021-pol2qm74 806 23 r=0.71 r=0.71 NNP cord-015021-pol2qm74 806 24 ) ) -RRB- cord-015021-pol2qm74 806 25 . . . cord-015021-pol2qm74 807 1 CONCLUSIONS conclusion NNS cord-015021-pol2qm74 807 2 : : : cord-015021-pol2qm74 808 1 There there EX cord-015021-pol2qm74 808 2 is be VBZ cord-015021-pol2qm74 808 3 a a DT cord-015021-pol2qm74 808 4 positive positive JJ cord-015021-pol2qm74 808 5 correlation correlation NN cord-015021-pol2qm74 808 6 between between IN cord-015021-pol2qm74 808 7 the the DT cord-015021-pol2qm74 808 8 time time NN cord-015021-pol2qm74 808 9 pattern pattern NN cord-015021-pol2qm74 808 10 of of IN cord-015021-pol2qm74 808 11 intestinal intestinal JJ cord-015021-pol2qm74 808 12 permeability permeability NN cord-015021-pol2qm74 808 13 dysfunction dysfunction NN cord-015021-pol2qm74 808 14 and and CC cord-015021-pol2qm74 808 15 RES res NN cord-015021-pol2qm74 808 16 hyperactivity hyperactivity NN cord-015021-pol2qm74 808 17 as as RB cord-015021-pol2qm74 808 18 well well RB cord-015021-pol2qm74 808 19 as as IN cord-015021-pol2qm74 808 20 between between IN cord-015021-pol2qm74 808 21 intestinal intestinal JJ cord-015021-pol2qm74 808 22 permeability permeability NN cord-015021-pol2qm74 808 23 and and CC cord-015021-pol2qm74 808 24 the the DT cord-015021-pol2qm74 808 25 systemic systemic JJ cord-015021-pol2qm74 808 26 intlammatory intlammatory JJ cord-015021-pol2qm74 808 27 response response NN cord-015021-pol2qm74 808 28 ( ( -LRB- cord-015021-pol2qm74 808 29 elastase elastase NN cord-015021-pol2qm74 808 30 levels level NNS cord-015021-pol2qm74 808 31 ) ) -RRB- cord-015021-pol2qm74 808 32 . . . cord-015021-pol2qm74 809 1 The the DT cord-015021-pol2qm74 809 2 results result NNS cord-015021-pol2qm74 809 3 speak speak VBP cord-015021-pol2qm74 809 4 in in IN cord-015021-pol2qm74 809 5 favor favor NN cord-015021-pol2qm74 809 6 of of IN cord-015021-pol2qm74 809 7 an an DT cord-015021-pol2qm74 809 8 interaction interaction NN cord-015021-pol2qm74 809 9 between between IN cord-015021-pol2qm74 809 10 intestinal intestinal JJ cord-015021-pol2qm74 809 11 and and CC cord-015021-pol2qm74 809 12 extraintestinal extraintestinal JJ cord-015021-pol2qm74 809 13 inflammatory inflammatory JJ cord-015021-pol2qm74 809 14 systems system NNS cord-015021-pol2qm74 809 15 , , , cord-015021-pol2qm74 809 16 which which WDT cord-015021-pol2qm74 809 17 in in IN cord-015021-pol2qm74 809 18 eombiuation eombiuation NN cord-015021-pol2qm74 809 19 are be VBP cord-015021-pol2qm74 809 20 likely likely JJ cord-015021-pol2qm74 809 21 to to TO cord-015021-pol2qm74 809 22 be be VB cord-015021-pol2qm74 809 23 responsible responsible JJ cord-015021-pol2qm74 809 24 for for IN cord-015021-pol2qm74 809 25 post post NNP cord-015021-pol2qm74 809 26 ~ ~ CD cord-015021-pol2qm74 809 27 anmafic anmafic JJ cord-015021-pol2qm74 809 28 complications complication NNS cord-015021-pol2qm74 809 29 . . . cord-015021-pol2qm74 810 1 Endotoxemia Endotoxemia NNP cord-015021-pol2qm74 810 2 , , , cord-015021-pol2qm74 811 1 IL-6 IL-6 NNP cord-015021-pol2qm74 811 2 release release NN cord-015021-pol2qm74 811 3 and and CC cord-015021-pol2qm74 811 4 consecutive consecutive JJ cord-015021-pol2qm74 811 5 acute acute JJ cord-015021-pol2qm74 811 6 phase phase NN cord-015021-pol2qm74 811 7 reaction reaction NN cord-015021-pol2qm74 811 8 are be VBP cord-015021-pol2qm74 811 9 observed observe VBN cord-015021-pol2qm74 811 10 as as IN cord-015021-pol2qm74 811 11 a a DT cord-015021-pol2qm74 811 12 host host NN cord-015021-pol2qm74 811 13 response response NN cord-015021-pol2qm74 811 14 to to IN cord-015021-pol2qm74 811 15 surgical surgical JJ cord-015021-pol2qm74 811 16 trauma trauma NN cord-015021-pol2qm74 811 17 . . . cord-015021-pol2qm74 812 1 As as IN cord-015021-pol2qm74 812 2 well well RB cord-015021-pol2qm74 812 3 vasodilative vasodilative JJ cord-015021-pol2qm74 812 4 prostaglandins prostaglandin NNS cord-015021-pol2qm74 812 5 ( ( -LRB- cord-015021-pol2qm74 812 6 PG PG NNP cord-015021-pol2qm74 812 7 ) ) -RRB- cord-015021-pol2qm74 812 8 and and CC cord-015021-pol2qm74 812 9 thromboxane thromboxane NNP cord-015021-pol2qm74 812 10 ( ( -LRB- cord-015021-pol2qm74 812 11 TX TX NNP cord-015021-pol2qm74 812 12 ) ) -RRB- cord-015021-pol2qm74 812 13 are be VBP cord-015021-pol2qm74 812 14 released release VBN cord-015021-pol2qm74 812 15 after after IN cord-015021-pol2qm74 812 16 abdominal abdominal JJ cord-015021-pol2qm74 812 17 meaenteric meaenteric JJ cord-015021-pol2qm74 812 18 traction traction NN cord-015021-pol2qm74 812 19 ( ( -LRB- cord-015021-pol2qm74 812 20 MT MT NNP cord-015021-pol2qm74 812 21 ) ) -RRB- cord-015021-pol2qm74 812 22 . . . cord-015021-pol2qm74 813 1 The the DT cord-015021-pol2qm74 813 2 following follow VBG cord-015021-pol2qm74 813 3 hypotension hypotension NN cord-015021-pol2qm74 813 4 and and CC cord-015021-pol2qm74 813 5 acute acute JJ cord-015021-pol2qm74 813 6 hypoxeraJa hypoxeraJa NNS cord-015021-pol2qm74 813 7 are be VBP cord-015021-pol2qm74 813 8 duo duo JJ cord-015021-pol2qm74 813 9 to to IN cord-015021-pol2qm74 813 10 prostacyelin prostacyelin NNP cord-015021-pol2qm74 813 11 ( ( -LRB- cord-015021-pol2qm74 813 12 PGIz PGIz NNP cord-015021-pol2qm74 813 13 ) ) -RRB- cord-015021-pol2qm74 813 14 arm arm NN cord-015021-pol2qm74 813 15 can can MD cord-015021-pol2qm74 813 16 be be VB cord-015021-pol2qm74 813 17 avoided avoid VBN cord-015021-pol2qm74 813 18 by by IN cord-015021-pol2qm74 813 19 perioperative perioperative JJ cord-015021-pol2qm74 813 20 cyclooxygenase cyclooxygenase JJ cord-015021-pol2qm74 813 21 inhibition inhibition NN cord-015021-pol2qm74 813 22 . . . cord-015021-pol2qm74 814 1 We -PRON- PRP cord-015021-pol2qm74 814 2 therefore therefore RB cord-015021-pol2qm74 814 3 focused focus VBD cord-015021-pol2qm74 814 4 on on IN cord-015021-pol2qm74 814 5 the the DT cord-015021-pol2qm74 814 6 effect effect NN cord-015021-pol2qm74 814 7 of of IN cord-015021-pol2qm74 814 8 PG PG NNP cord-015021-pol2qm74 814 9 and and CC cord-015021-pol2qm74 814 10 TX TX NNP cord-015021-pol2qm74 814 11 liberated liberate VBD cord-015021-pol2qm74 814 12 following follow VBG cord-015021-pol2qm74 814 13 MT MT NNP cord-015021-pol2qm74 814 14 on on IN cord-015021-pol2qm74 814 15 the the DT cord-015021-pol2qm74 814 16 induction induction NN cord-015021-pol2qm74 814 17 of of IN cord-015021-pol2qm74 814 18 endotoxemia endotoxemia NN cord-015021-pol2qm74 814 19 . . . cord-015021-pol2qm74 815 1 METHODS methods NN cord-015021-pol2qm74 815 2 : : : cord-015021-pol2qm74 816 1 In in IN cord-015021-pol2qm74 816 2 a a DT cord-015021-pol2qm74 816 3 prospective prospective NN cord-015021-pol2qm74 816 4 , , , cord-015021-pol2qm74 816 5 randomized randomized JJ cord-015021-pol2qm74 816 6 double double JJ cord-015021-pol2qm74 816 7 - - HYPH cord-015021-pol2qm74 816 8 blinded blinded JJ cord-015021-pol2qm74 816 9 protocol protocol NN cord-015021-pol2qm74 816 10 50 50 CD cord-015021-pol2qm74 816 11 patients patient NNS cord-015021-pol2qm74 816 12 , , , cord-015021-pol2qm74 816 13 who who WP cord-015021-pol2qm74 816 14 were be VBD cord-015021-pol2qm74 816 15 scheduled schedule VBN cord-015021-pol2qm74 816 16 for for IN cord-015021-pol2qm74 816 17 major major JJ cord-015021-pol2qm74 816 18 abdominal abdominal JJ cord-015021-pol2qm74 816 19 surgery surgery NN cord-015021-pol2qm74 816 20 ( ( -LRB- cord-015021-pol2qm74 816 21 pancreatic pancreatic JJ cord-015021-pol2qm74 816 22 or or CC cord-015021-pol2qm74 816 23 infrarenal infrarenal JJ cord-015021-pol2qm74 816 24 abdominal abdominal JJ cord-015021-pol2qm74 816 25 surgery surgery NN cord-015021-pol2qm74 816 26 ) ) -RRB- cord-015021-pol2qm74 816 27 , , , cord-015021-pol2qm74 816 28 were be VBD cord-015021-pol2qm74 816 29 studied study VBN cord-015021-pol2qm74 816 30 . . . cord-015021-pol2qm74 817 1 Ibuprofen ibuprofen NN cord-015021-pol2qm74 817 2 ( ( -LRB- cord-015021-pol2qm74 817 3 400 400 CD cord-015021-pol2qm74 817 4 mg mg NNP cord-015021-pol2qm74 817 5 i.v i.v NNP cord-015021-pol2qm74 817 6 . . NNP cord-015021-pol2qm74 817 7 ) ) -RRB- cord-015021-pol2qm74 817 8 or or CC cord-015021-pol2qm74 817 9 a a DT cord-015021-pol2qm74 817 10 placebo placebo NN cord-015021-pol2qm74 817 11 equivalent equivalent NN cord-015021-pol2qm74 817 12 was be VBD cord-015021-pol2qm74 817 13 administered administer VBN cord-015021-pol2qm74 817 14 15 15 CD cord-015021-pol2qm74 817 15 minutes minute NNS cord-015021-pol2qm74 817 16 before before IN cord-015021-pol2qm74 817 17 skin skin NN cord-015021-pol2qm74 817 18 incision incision NN cord-015021-pol2qm74 817 19 . . . cord-015021-pol2qm74 818 1 MT MT NNP cord-015021-pol2qm74 818 2 was be VBD cord-015021-pol2qm74 818 3 applied apply VBN cord-015021-pol2qm74 818 4 in in IN cord-015021-pol2qm74 818 5 a a DT cord-015021-pol2qm74 818 6 uniform uniform JJ cord-015021-pol2qm74 818 7 fashion fashion NN cord-015021-pol2qm74 818 8 . . . cord-015021-pol2qm74 819 1 Baseline baseline JJ cord-015021-pol2qm74 819 2 values value NNS cord-015021-pol2qm74 819 3 were be VBD cord-015021-pol2qm74 819 4 obtained obtain VBN cord-015021-pol2qm74 819 5 before before IN cord-015021-pol2qm74 819 6 induction induction NN cord-015021-pol2qm74 819 7 of of IN cord-015021-pol2qm74 819 8 anesthesia anesthesia NN cord-015021-pol2qm74 819 9 . . . cord-015021-pol2qm74 820 1 Further further JJ cord-015021-pol2qm74 820 2 measurements measurement NNS cord-015021-pol2qm74 820 3 followed follow VBN cord-015021-pol2qm74 820 4 before before IN cord-015021-pol2qm74 820 5 the the DT cord-015021-pol2qm74 820 6 incision incision NN cord-015021-pol2qm74 820 7 of of IN cord-015021-pol2qm74 820 8 the the DT cord-015021-pol2qm74 820 9 peri[onenm peri[onenm NNS cord-015021-pol2qm74 820 10 ( ( -LRB- cord-015021-pol2qm74 820 11 tl tl NNP cord-015021-pol2qm74 820 12 ) ) -RRB- cord-015021-pol2qm74 820 13 and and CC cord-015021-pol2qm74 820 14 5 5 CD cord-015021-pol2qm74 820 15 , , , cord-015021-pol2qm74 820 16 30 30 CD cord-015021-pol2qm74 820 17 , , , cord-015021-pol2qm74 820 18 90 90 CD cord-015021-pol2qm74 820 19 , , , cord-015021-pol2qm74 820 20 180 180 CD cord-015021-pol2qm74 820 21 min min NN cord-015021-pol2qm74 820 22 , , , cord-015021-pol2qm74 820 23 . . . cord-015021-pol2qm74 821 1 The the DT cord-015021-pol2qm74 821 2 plasma plasma NN cord-015021-pol2qm74 821 3 concentrations concentration NNS cord-015021-pol2qm74 821 4 ( ( -LRB- cord-015021-pol2qm74 821 5 , , , cord-015021-pol2qm74 821 6 pc pc NN cord-015021-pol2qm74 821 7 ) ) -RRB- cord-015021-pol2qm74 821 8 of of IN cord-015021-pol2qm74 821 9 6-keto 6-keto CD cord-015021-pol2qm74 821 10 - - HYPH cord-015021-pol2qm74 821 11 PGFt PGFt NNS cord-015021-pol2qm74 821 12 , , , cord-015021-pol2qm74 821 13 , , , cord-015021-pol2qm74 821 14 TXB TXB NNP cord-015021-pol2qm74 821 15 : : : cord-015021-pol2qm74 821 16 and and CC cord-015021-pol2qm74 821 17 - - HYPH cord-015021-pol2qm74 821 18 KI-12-PGF ki-12-pgf NN cord-015021-pol2qm74 821 19 ~ ~ NFP cord-015021-pol2qm74 821 20 ( ( -LRB- cord-015021-pol2qm74 821 21 stable stable JJ cord-015021-pol2qm74 821 22 metabolites metabolite NNS cord-015021-pol2qm74 821 23 of of IN cord-015021-pol2qm74 821 24 PGI2 PGI2 NNP cord-015021-pol2qm74 821 25 , , , cord-015021-pol2qm74 821 26 TXA2 TXA2 NNP cord-015021-pol2qm74 821 27 and and CC cord-015021-pol2qm74 821 28 PGE~ PGE~ NNP cord-015021-pol2qm74 821 29 ) ) -RRB- cord-015021-pol2qm74 821 30 were be VBD cord-015021-pol2qm74 821 31 determined determine VBN cord-015021-pol2qm74 821 32 by by IN cord-015021-pol2qm74 821 33 RIA RIA NNP cord-015021-pol2qm74 821 34 . . . cord-015021-pol2qm74 822 1 We -PRON- PRP cord-015021-pol2qm74 822 2 measured measure VBD cord-015021-pol2qm74 822 3 Endotoxin endotoxin NN cord-015021-pol2qm74 822 4 pc pc NN cord-015021-pol2qm74 822 5 by by IN cord-015021-pol2qm74 822 6 Limulus Limulus NNP cord-015021-pol2qm74 822 7 - - HYPH cord-015021-pol2qm74 822 8 amoebocyte amoebocyte NN cord-015021-pol2qm74 822 9 - - HYPH cord-015021-pol2qm74 822 10 lysate lysate NN cord-015021-pol2qm74 822 11 test test NN cord-015021-pol2qm74 822 12 and and CC cord-015021-pol2qm74 822 13 IL-6 IL-6 NNP cord-015021-pol2qm74 822 14 levels level NNS cord-015021-pol2qm74 822 15 by by IN cord-015021-pol2qm74 822 16 ELISA ELISA NNP cord-015021-pol2qm74 822 17 . . . cord-015021-pol2qm74 823 1 Data datum NNS cord-015021-pol2qm74 823 2 are be VBP cord-015021-pol2qm74 823 3 given give VBN cord-015021-pol2qm74 823 4 as as IN cord-015021-pol2qm74 823 5 mean+SEM mean+sem NN cord-015021-pol2qm74 823 6 ( ( -LRB- cord-015021-pol2qm74 823 7 * * NFP cord-015021-pol2qm74 823 8 p p XX cord-015021-pol2qm74 823 9 < < XX cord-015021-pol2qm74 823 10 0.05 0.05 CD cord-015021-pol2qm74 823 11 placebo placebo NN cord-015021-pol2qm74 823 12 vs. vs. IN cord-015021-pol2qm74 823 13 [ [ -LRB- cord-015021-pol2qm74 823 14 ibuprofen ibuprofen NN cord-015021-pol2qm74 823 15 ] ] -RRB- cord-015021-pol2qm74 823 16 ) ) -RRB- cord-015021-pol2qm74 823 17 . . . cord-015021-pol2qm74 824 1 RESULTS result NNS cord-015021-pol2qm74 824 2 : : : cord-015021-pol2qm74 825 1 Endotoxin endotoxin NN cord-015021-pol2qm74 825 2 plasma plasma NN cord-015021-pol2qm74 825 3 levels level NNS cord-015021-pol2qm74 825 4 increased increase VBD cord-015021-pol2qm74 825 5 before before IN cord-015021-pol2qm74 825 6 incision incision NN cord-015021-pol2qm74 825 7 of of IN cord-015021-pol2qm74 825 8 the the DT cord-015021-pol2qm74 825 9 peritoneum peritoneum NN cord-015021-pol2qm74 825 10 tl tl NN cord-015021-pol2qm74 825 11 both both CC cord-015021-pol2qm74 825 12 in in IN cord-015021-pol2qm74 825 13 the the DT cord-015021-pol2qm74 825 14 ibuprofen ibuprofen NN cord-015021-pol2qm74 825 15 pretreated pretreate VBN cord-015021-pol2qm74 825 16 and and CC cord-015021-pol2qm74 825 17 in in IN cord-015021-pol2qm74 825 18 the the DT cord-015021-pol2qm74 825 19 placebo placebo NN cord-015021-pol2qm74 825 20 group group NN cord-015021-pol2qm74 825 21 . . . cord-015021-pol2qm74 826 1 Peak Peak NNP cord-015021-pol2qm74 826 2 pc pc NN cord-015021-pol2qm74 826 3 were be VBD cord-015021-pol2qm74 826 4 observed observe VBN cord-015021-pol2qm74 826 5 180 180 CD cord-015021-pol2qm74 826 6 minutes minute NNS cord-015021-pol2qm74 826 7 after after IN cord-015021-pol2qm74 826 8 MT MT NNP cord-015021-pol2qm74 826 9 . . . cord-015021-pol2qm74 827 1 Endotoxin endotoxin NN cord-015021-pol2qm74 827 2 pc pc NN cord-015021-pol2qm74 827 3 were be VBD cord-015021-pol2qm74 827 4 significantly significantly RB cord-015021-pol2qm74 827 5 higher high JJR cord-015021-pol2qm74 827 6 in in IN cord-015021-pol2qm74 827 7 the the DT cord-015021-pol2qm74 827 8 ibuprufen ibuprufen NN cord-015021-pol2qm74 827 9 treated treat VBN cord-015021-pol2qm74 827 10 group group NN cord-015021-pol2qm74 827 11 ( ( -LRB- cord-015021-pol2qm74 827 12 t5 t5 NNP cord-015021-pol2qm74 827 13 0.16 0.16 CD cord-015021-pol2qm74 827 14 + + SYM cord-015021-pol2qm74 827 15 0.02e[0.32 0.02e[0.32 CD cord-015021-pol2qm74 827 16 + + SYM cord-015021-pol2qm74 827 17 0.06 0.06 CD cord-015021-pol2qm74 827 18 ] ] -RRB- cord-015021-pol2qm74 828 1 EU EU NNP cord-015021-pol2qm74 828 2 / / SYM cord-015021-pol2qm74 828 3 ml ml NN cord-015021-pol2qm74 828 4 ) ) -RRB- cord-015021-pol2qm74 828 5 . . . cord-015021-pol2qm74 829 1 IL-6 IL-6 NNP cord-015021-pol2qm74 829 2 pc pc NNP cord-015021-pol2qm74 829 3 demonstrated demonstrate VBD cord-015021-pol2qm74 829 4 an an DT cord-015021-pol2qm74 829 5 increase increase NN cord-015021-pol2qm74 829 6 continuously continuously RB cord-015021-pol2qm74 829 7 from from IN cord-015021-pol2qm74 829 8 t4 t4 NNP cord-015021-pol2qm74 829 9 to to IN cord-015021-pol2qm74 829 10 t7 t7 NNP cord-015021-pol2qm74 829 11 ( ( -LRB- cord-015021-pol2qm74 829 12 t7 t7 NNP cord-015021-pol2qm74 829 13 115 115 CD cord-015021-pol2qm74 829 14 + + SYM cord-015021-pol2qm74 829 15 12 12 CD cord-015021-pol2qm74 829 16 [ [ -LRB- cord-015021-pol2qm74 829 17 91 91 CD cord-015021-pol2qm74 829 18 + + SYM cord-015021-pol2qm74 829 19 15 15 CD cord-015021-pol2qm74 829 20 ] ] -RRB- cord-015021-pol2qm74 830 1 ng ng NNP cord-015021-pol2qm74 830 2 / / SYM cord-015021-pol2qm74 830 3 l l NNP cord-015021-pol2qm74 830 4 ) ) -RRB- cord-015021-pol2qm74 830 5 in in IN cord-015021-pol2qm74 830 6 both both DT cord-015021-pol2qm74 830 7 groups group NNS cord-015021-pol2qm74 830 8 . . . cord-015021-pol2qm74 831 1 After after IN cord-015021-pol2qm74 831 2 intentional intentional JJ cord-015021-pol2qm74 831 3 abdominal abdominal JJ cord-015021-pol2qm74 831 4 mesenteric mesenteric JJ cord-015021-pol2qm74 831 5 traction traction NN cord-015021-pol2qm74 831 6 we -PRON- PRP cord-015021-pol2qm74 831 7 observed observe VBD cord-015021-pol2qm74 831 8 a a DT cord-015021-pol2qm74 831 9 marked marked JJ cord-015021-pol2qm74 831 10 increase increase NN cord-015021-pol2qm74 831 11 of of IN cord-015021-pol2qm74 831 12 6-keto 6-keto CD cord-015021-pol2qm74 831 13 - - HYPH cord-015021-pol2qm74 831 14 PGF~ PGF~ NNP cord-015021-pol2qm74 831 15 , , , cord-015021-pol2qm74 831 16 , , , cord-015021-pol2qm74 831 17 pc pc VB cord-015021-pol2qm74 831 18 up up IN cord-015021-pol2qm74 831 19 to to IN cord-015021-pol2qm74 831 20 6h 6h CD cord-015021-pol2qm74 831 21 after after IN cord-015021-pol2qm74 831 22 MT MT NNP cord-015021-pol2qm74 831 23 in in IN cord-015021-pol2qm74 831 24 untreated untreated JJ cord-015021-pol2qm74 831 25 patients patient NNS cord-015021-pol2qm74 831 26 with with IN cord-015021-pol2qm74 831 27 a a DT cord-015021-pol2qm74 831 28 peak peak NN cord-015021-pol2qm74 831 29 of of IN cord-015021-pol2qm74 831 30 2450*[60 2450*[60 CD cord-015021-pol2qm74 831 31 ] ] -RRB- cord-015021-pol2qm74 832 1 ng/1 ng/1 NNP cord-015021-pol2qm74 832 2 at at IN cord-015021-pol2qm74 832 3 tl tl NNP cord-015021-pol2qm74 832 4 . . . cord-015021-pol2qm74 833 1 Also also RB cord-015021-pol2qm74 833 2 TXB TXB NNP cord-015021-pol2qm74 833 3 : : : cord-015021-pol2qm74 833 4 and and CC cord-015021-pol2qm74 834 1 KH2PGE KH2PGE NNP cord-015021-pol2qm74 834 2 2 2 CD cord-015021-pol2qm74 834 3 pc pc NNP cord-015021-pol2qm74 834 4 showed show VBD cord-015021-pol2qm74 834 5 a a DT cord-015021-pol2qm74 834 6 considerabe considerabe NN cord-015021-pol2qm74 834 7 increase increase VB cord-015021-pol2qm74 834 8 up up RB cord-015021-pol2qm74 834 9 to to IN cord-015021-pol2qm74 834 10 6h 6h CD cord-015021-pol2qm74 834 11 after after IN cord-015021-pol2qm74 834 12 MT MT NNP cord-015021-pol2qm74 834 13 in in IN cord-015021-pol2qm74 834 14 the the DT cord-015021-pol2qm74 834 15 placebo placebo NN cord-015021-pol2qm74 834 16 group group NN cord-015021-pol2qm74 834 17 . . . cord-015021-pol2qm74 835 1 In in IN cord-015021-pol2qm74 835 2 ibuprofen ibuprofen NN cord-015021-pol2qm74 835 3 pretreated pretreate VBD cord-015021-pol2qm74 835 4 patients patient NNS cord-015021-pol2qm74 835 5 the the DT cord-015021-pol2qm74 835 6 PG PG NNP cord-015021-pol2qm74 835 7 and and CC cord-015021-pol2qm74 835 8 TX TX NNP cord-015021-pol2qm74 835 9 pc pc NNP cord-015021-pol2qm74 835 10 remained remain VBD cord-015021-pol2qm74 835 11 within within IN cord-015021-pol2qm74 835 12 the the DT cord-015021-pol2qm74 835 13 normal normal JJ cord-015021-pol2qm74 835 14 range range NN cord-015021-pol2qm74 835 15 . . . cord-015021-pol2qm74 836 1 DISCUSSION discussion NN cord-015021-pol2qm74 836 2 : : : cord-015021-pol2qm74 837 1 Our -PRON- PRP$ cord-015021-pol2qm74 837 2 data datum NNS cord-015021-pol2qm74 837 3 clearly clearly RB cord-015021-pol2qm74 837 4 indicate indicate VBP cord-015021-pol2qm74 837 5 a a DT cord-015021-pol2qm74 837 6 significant significant JJ cord-015021-pol2qm74 837 7 endotoxemia endotoxemia NN cord-015021-pol2qm74 837 8 and and CC cord-015021-pol2qm74 837 9 IL-6 IL-6 NNP cord-015021-pol2qm74 837 10 release release NN cord-015021-pol2qm74 837 11 following follow VBG cord-015021-pol2qm74 837 12 major major JJ cord-015021-pol2qm74 837 13 surgical surgical JJ cord-015021-pol2qm74 837 14 trauma trauma NN cord-015021-pol2qm74 837 15 which which WDT cord-015021-pol2qm74 837 16 is be VBZ cord-015021-pol2qm74 837 17 not not RB cord-015021-pol2qm74 837 18 initiated initiate VBN cord-015021-pol2qm74 837 19 either either CC cord-015021-pol2qm74 837 20 by by IN cord-015021-pol2qm74 837 21 prostaglandin prostaglandin NN cord-015021-pol2qm74 837 22 or or CC cord-015021-pol2qm74 837 23 thromboxane thromboxane NN cord-015021-pol2qm74 837 24 release release NN cord-015021-pol2qm74 837 25 . . . cord-015021-pol2qm74 838 1 Moreover moreover RB cord-015021-pol2qm74 838 2 endotoxemia endotoxemia NN cord-015021-pol2qm74 838 3 is be VBZ cord-015021-pol2qm74 838 4 accentuated accentuate VBN cord-015021-pol2qm74 838 5 by by IN cord-015021-pol2qm74 838 6 ibuprofen ibuprofen NN cord-015021-pol2qm74 838 7 pretreatment pretreatment NN cord-015021-pol2qm74 838 8 . . . cord-015021-pol2qm74 839 1 Therefore therefore RB cord-015021-pol2qm74 839 2 we -PRON- PRP cord-015021-pol2qm74 839 3 hypothesize hypothesize VBP cord-015021-pol2qm74 839 4 that that IN cord-015021-pol2qm74 839 5 in in IN cord-015021-pol2qm74 839 6 major major JJ cord-015021-pol2qm74 839 7 abdominal abdominal JJ cord-015021-pol2qm74 839 8 surgery surgery NN cord-015021-pol2qm74 839 9 prostacyclin prostacyclin JJ cord-015021-pol2qm74 839 10 release release NN cord-015021-pol2qm74 839 11 - - : cord-015021-pol2qm74 839 12 after after IN cord-015021-pol2qm74 839 13 MT MT NNP cord-015021-pol2qm74 839 14 may may MD cord-015021-pol2qm74 839 15 play play VB cord-015021-pol2qm74 839 16 a a DT cord-015021-pol2qm74 839 17 crucial crucial JJ cord-015021-pol2qm74 839 18 physiological physiological JJ cord-015021-pol2qm74 839 19 role role NN cord-015021-pol2qm74 839 20 in in IN cord-015021-pol2qm74 839 21 maintaining maintain VBG cord-015021-pol2qm74 839 22 splanclmic splanclmic NNP cord-015021-pol2qm74 839 23 microcirculation microcirculation NNP cord-015021-pol2qm74 839 24 and and CC cord-015021-pol2qm74 839 25 thus thus RB cord-015021-pol2qm74 839 26 preserving preserve VBG cord-015021-pol2qm74 839 27 gut gut NN cord-015021-pol2qm74 839 28 mucosal mucosal JJ cord-015021-pol2qm74 839 29 barrier barrier NN cord-015021-pol2qm74 839 30 function function NN cord-015021-pol2qm74 839 31 . . . cord-015021-pol2qm74 840 1 Objectives objective NNS cord-015021-pol2qm74 840 2 of of IN cord-015021-pol2qm74 840 3 the the DT cord-015021-pol2qm74 840 4 study study NN cord-015021-pol2qm74 840 5 It -PRON- PRP cord-015021-pol2qm74 840 6 has have VBZ cord-015021-pol2qm74 840 7 been be VBN cord-015021-pol2qm74 840 8 shown show VBN cord-015021-pol2qm74 840 9 recently recently RB cord-015021-pol2qm74 840 10 that that IN cord-015021-pol2qm74 840 11 parenteral parenteral JJ cord-015021-pol2qm74 840 12 and and CC cord-015021-pol2qm74 840 13 certain certain JJ cord-015021-pol2qm74 840 14 euteral euteral JJ cord-015021-pol2qm74 840 15 diets diet NNS cord-015021-pol2qm74 840 16 promote promote VBP cord-015021-pol2qm74 840 17 the the DT cord-015021-pol2qm74 840 18 translocation translocation NN cord-015021-pol2qm74 840 19 of of IN cord-015021-pol2qm74 840 20 gut gut NN cord-015021-pol2qm74 840 21 flora flora NNS cord-015021-pol2qm74 840 22 to to IN cord-015021-pol2qm74 840 23 the the DT cord-015021-pol2qm74 840 24 mesenteric mesenteric JJ cord-015021-pol2qm74 840 25 lymph lymph NN cord-015021-pol2qm74 840 26 nodes node NNS cord-015021-pol2qm74 840 27 ( ( -LRB- cord-015021-pol2qm74 840 28 MLN mln NN cord-015021-pol2qm74 840 29 ) ) -RRB- cord-015021-pol2qm74 840 30 and and CC cord-015021-pol2qm74 840 31 systemic systemic JJ cord-015021-pol2qm74 840 32 organs organ NNS cord-015021-pol2qm74 840 33 , , , cord-015021-pol2qm74 840 34 a a DT cord-015021-pol2qm74 840 35 process process NN cord-015021-pol2qm74 840 36 termed term VBN cord-015021-pol2qm74 840 37 bacterial bacterial JJ cord-015021-pol2qm74 840 38 translocation translocation NN cord-015021-pol2qm74 840 39 ( ( -LRB- cord-015021-pol2qm74 840 40 BT BT NNP cord-015021-pol2qm74 840 41 ) ) -RRB- cord-015021-pol2qm74 840 42 . . . cord-015021-pol2qm74 841 1 In in IN cord-015021-pol2qm74 841 2 chow chow NN cord-015021-pol2qm74 841 3 fed feed VBD cord-015021-pol2qm74 841 4 rats rat NNS cord-015021-pol2qm74 841 5 BT BT NNP cord-015021-pol2qm74 841 6 usually usually RB cord-015021-pol2qm74 841 7 does do VBZ cord-015021-pol2qm74 841 8 not not RB cord-015021-pol2qm74 841 9 occur occur VB cord-015021-pol2qm74 841 10 without without IN cord-015021-pol2qm74 841 11 further further JJ cord-015021-pol2qm74 841 12 promoting promote VBG cord-015021-pol2qm74 841 13 factors factor NNS cord-015021-pol2qm74 841 14 . . . cord-015021-pol2qm74 842 1 The the DT cord-015021-pol2qm74 842 2 goals goal NNS cord-015021-pol2qm74 842 3 of of IN cord-015021-pol2qm74 842 4 the the DT cord-015021-pol2qm74 842 5 present present JJ cord-015021-pol2qm74 842 6 study study NN cord-015021-pol2qm74 842 7 were be VBD cord-015021-pol2qm74 842 8 to to TO cord-015021-pol2qm74 842 9 determine determine VB cord-015021-pol2qm74 842 10 whether whether IN cord-015021-pol2qm74 842 11 the the DT cord-015021-pol2qm74 842 12 provision provision NN cord-015021-pol2qm74 842 13 of of IN cord-015021-pol2qm74 842 14 defined define VBN cord-015021-pol2qm74 842 15 amounts amount NNS cord-015021-pol2qm74 842 16 of of IN cord-015021-pol2qm74 842 17 standard standard JJ cord-015021-pol2qm74 842 18 lab lab NN cord-015021-pol2qm74 842 19 chow chow NN cord-015021-pol2qm74 842 20 during during IN cord-015021-pol2qm74 842 21 IV IV NNP cord-015021-pol2qm74 842 22 - - HYPH cord-015021-pol2qm74 842 23 TPN TPN NNP cord-015021-pol2qm74 842 24 administration administration NN cord-015021-pol2qm74 842 25 wotfld wotfld NNP cord-015021-pol2qm74 842 26 redane redane NNP cord-015021-pol2qm74 842 27 the the DT cord-015021-pol2qm74 842 28 incidence incidence NN cord-015021-pol2qm74 842 29 of of IN cord-015021-pol2qm74 842 30 BT BT NNP cord-015021-pol2qm74 842 31 , , , cord-015021-pol2qm74 842 32 Materials material NNS cord-015021-pol2qm74 842 33 und und IN cord-015021-pol2qm74 842 34 methods method NNS cord-015021-pol2qm74 843 1 Male male JJ cord-015021-pol2qm74 843 2 SPF SPF NNP cord-015021-pol2qm74 843 3 Spragnle Spragnle NNP cord-015021-pol2qm74 843 4 - - HYPH cord-015021-pol2qm74 843 5 Dawley Dawley NNP cord-015021-pol2qm74 843 6 rats rat NNS cord-015021-pol2qm74 843 7 were be VBD cord-015021-pol2qm74 843 8 divided divide VBN cord-015021-pol2qm74 843 9 into into IN cord-015021-pol2qm74 843 10 6 6 CD cord-015021-pol2qm74 843 11 groups group NNS cord-015021-pol2qm74 843 12 . . . cord-015021-pol2qm74 844 1 Group group NN cord-015021-pol2qm74 844 2 1 1 CD cord-015021-pol2qm74 844 3 received receive VBD cord-015021-pol2qm74 844 4 standard standard JJ cord-015021-pol2qm74 844 5 laboratory laboratory NN cord-015021-pol2qm74 844 6 chow chow NN cord-015021-pol2qm74 844 7 feeding feeding NNP cord-015021-pol2qm74 844 8 ad ad NN cord-015021-pol2qm74 844 9 lib lib NN cord-015021-pol2qm74 844 10 . . . cord-015021-pol2qm74 845 1 In in IN cord-015021-pol2qm74 845 2 group group NN cord-015021-pol2qm74 845 3 2 2 CD cord-015021-pol2qm74 845 4 a a DT cord-015021-pol2qm74 845 5 central central JJ cord-015021-pol2qm74 845 6 venous venous JJ cord-015021-pol2qm74 845 7 catheter catheter NN cord-015021-pol2qm74 845 8 was be VBD cord-015021-pol2qm74 845 9 placed place VBN cord-015021-pol2qm74 845 10 , , , cord-015021-pol2qm74 845 11 ligated ligate VBN cord-015021-pol2qm74 845 12 and and CC cord-015021-pol2qm74 845 13 secured secure VBN cord-015021-pol2qm74 845 14 by by IN cord-015021-pol2qm74 845 15 a a DT cord-015021-pol2qm74 845 16 spring spring NN cord-015021-pol2qm74 845 17 coil coil NN cord-015021-pol2qm74 845 18 tether tether NN cord-015021-pol2qm74 845 19 attached attach VBN cord-015021-pol2qm74 845 20 to to IN cord-015021-pol2qm74 845 21 a a DT cord-015021-pol2qm74 845 22 swivel swivel NN cord-015021-pol2qm74 845 23 allowing allow VBG cord-015021-pol2qm74 845 24 free free JJ cord-015021-pol2qm74 845 25 movement movement NN cord-015021-pol2qm74 845 26 in in IN cord-015021-pol2qm74 845 27 the the DT cord-015021-pol2qm74 845 28 housing housing NN cord-015021-pol2qm74 845 29 cage cage NN cord-015021-pol2qm74 845 30 and and CC cord-015021-pol2qm74 845 31 chow chow NNP cord-015021-pol2qm74 845 32 was be VBD cord-015021-pol2qm74 845 33 fed fed NNP cord-015021-pol2qm74 845 34 ad ad NN cord-015021-pol2qm74 845 35 lib lib NN cord-015021-pol2qm74 845 36 . . . cord-015021-pol2qm74 846 1 In in IN cord-015021-pol2qm74 846 2 group group NN cord-015021-pol2qm74 846 3 3 3 CD cord-015021-pol2qm74 846 4 50 50 CD cord-015021-pol2qm74 846 5 % % NN cord-015021-pol2qm74 846 6 of of IN cord-015021-pol2qm74 846 7 the the DT cord-015021-pol2qm74 846 8 calculated calculate VBN cord-015021-pol2qm74 846 9 daily daily RB cord-015021-pol2qm74 846 10 required require VBN cord-015021-pol2qm74 846 11 calory calory NN cord-015021-pol2qm74 846 12 intake intake NN cord-015021-pol2qm74 846 13 ( ( -LRB- cord-015021-pol2qm74 846 14 DRCI DRCI NNP cord-015021-pol2qm74 846 15 ) ) -RRB- cord-015021-pol2qm74 846 16 ( ( -LRB- cord-015021-pol2qm74 846 17 307 307 CD cord-015021-pol2qm74 846 18 / / SYM cord-015021-pol2qm74 846 19 Kcal Kcal NNP cord-015021-pol2qm74 846 20 / / SYM cord-015021-pol2qm74 846 21 kg kg NNP cord-015021-pol2qm74 846 22 ) ) -RRB- cord-015021-pol2qm74 846 23 was be VBD cord-015021-pol2qm74 846 24 given give VBN cord-015021-pol2qm74 846 25 by by IN cord-015021-pol2qm74 846 26 IV IV NNP cord-015021-pol2qm74 846 27 - - HYPH cord-015021-pol2qm74 846 28 TPN TPN NNP cord-015021-pol2qm74 846 29 ( ( -LRB- cord-015021-pol2qm74 846 30 28 28 CD cord-015021-pol2qm74 846 31 % % NN cord-015021-pol2qm74 846 32 glucose glucose NN cord-015021-pol2qm74 846 33 , , , cord-015021-pol2qm74 846 34 4,25 4,25 CD cord-015021-pol2qm74 846 35 % % NN cord-015021-pol2qm74 846 36 amino amino JJ cord-015021-pol2qm74 846 37 acids acid NNS cord-015021-pol2qm74 846 38 ) ) -RRB- cord-015021-pol2qm74 846 39 and and CC cord-015021-pol2qm74 846 40 50 50 CD cord-015021-pol2qm74 846 41 % % NN cord-015021-pol2qm74 846 42 by by IN cord-015021-pol2qm74 846 43 limited limited NNP cord-015021-pol2qm74 846 44 chow chow NNP cord-015021-pol2qm74 846 45 administration administration NNP cord-015021-pol2qm74 846 46 . . . cord-015021-pol2qm74 847 1 Groups group NNS cord-015021-pol2qm74 847 2 4 4 CD cord-015021-pol2qm74 847 3 and and CC cord-015021-pol2qm74 847 4 5 5 CD cord-015021-pol2qm74 847 5 received receive VBD cord-015021-pol2qm74 847 6 70 70 CD cord-015021-pol2qm74 847 7 % % NN cord-015021-pol2qm74 847 8 and and CC cord-015021-pol2qm74 847 9 90 90 CD cord-015021-pol2qm74 847 10 % % NN cord-015021-pol2qm74 847 11 of of IN cord-015021-pol2qm74 847 12 the the DT cord-015021-pol2qm74 847 13 DRCI DRCI NNP cord-015021-pol2qm74 847 14 by by IN cord-015021-pol2qm74 847 15 i.v i.v NNP cord-015021-pol2qm74 847 16 . . . cord-015021-pol2qm74 847 17 TPN TPN NNP cord-015021-pol2qm74 847 18 and and CC cord-015021-pol2qm74 847 19 30 30 CD cord-015021-pol2qm74 847 20 % % NN cord-015021-pol2qm74 847 21 and and CC cord-015021-pol2qm74 847 22 10 10 CD cord-015021-pol2qm74 847 23 % % NN cord-015021-pol2qm74 847 24 respectively respectively RB cord-015021-pol2qm74 847 25 by by IN cord-015021-pol2qm74 847 26 chow chow NN cord-015021-pol2qm74 847 27 feeding feeding NN cord-015021-pol2qm74 847 28 . . . cord-015021-pol2qm74 848 1 Group group NN cord-015021-pol2qm74 848 2 6 6 CD cord-015021-pol2qm74 848 3 received receive VBD cord-015021-pol2qm74 848 4 IV IV NNP cord-015021-pol2qm74 848 5 - - HYPH cord-015021-pol2qm74 848 6 TPN TPN NNP cord-015021-pol2qm74 848 7 only only RB cord-015021-pol2qm74 848 8 . . . cord-015021-pol2qm74 849 1 After after IN cord-015021-pol2qm74 849 2 7 7 CD cord-015021-pol2qm74 849 3 days day NNS cord-015021-pol2qm74 849 4 the the DT cord-015021-pol2qm74 849 5 rats rat NNS cord-015021-pol2qm74 849 6 were be VBD cord-015021-pol2qm74 849 7 sacrificed sacrifice VBN cord-015021-pol2qm74 849 8 and and CC cord-015021-pol2qm74 849 9 the the DT cord-015021-pol2qm74 849 10 MLN mln NN cord-015021-pol2qm74 849 11 , , , cord-015021-pol2qm74 849 12 liver liver NN cord-015021-pol2qm74 849 13 , , , cord-015021-pol2qm74 849 14 spleen spleen NN cord-015021-pol2qm74 849 15 and and CC cord-015021-pol2qm74 849 16 cecum cecum NN cord-015021-pol2qm74 849 17 removed remove VBN cord-015021-pol2qm74 849 18 aseptically aseptically RB cord-015021-pol2qm74 849 19 , , , cord-015021-pol2qm74 849 20 homogenized homogenize VBN cord-015021-pol2qm74 849 21 and and CC cord-015021-pol2qm74 849 22 cultured cultured JJ cord-015021-pol2qm74 849 23 for for IN cord-015021-pol2qm74 849 24 BT BT NNP cord-015021-pol2qm74 849 25 Samples sample NNS cord-015021-pol2qm74 849 26 of of IN cord-015021-pol2qm74 849 27 distal distal JJ cord-015021-pol2qm74 849 28 ileum ileum NN cord-015021-pol2qm74 849 29 were be VBD cord-015021-pol2qm74 849 30 taken take VBN cord-015021-pol2qm74 849 31 for for IN cord-015021-pol2qm74 849 32 light light JJ cord-015021-pol2qm74 849 33 microscopy microscopy NNS cord-015021-pol2qm74 849 34 . . . cord-015021-pol2qm74 850 1 The the DT cord-015021-pol2qm74 850 2 group group NN cord-015021-pol2qm74 850 3 with with IN cord-015021-pol2qm74 850 4 the the DT cord-015021-pol2qm74 850 5 least least JJS cord-015021-pol2qm74 850 6 amount amount NN cord-015021-pol2qm74 850 7 of of IN cord-015021-pol2qm74 850 8 chow chow NN cord-015021-pol2qm74 850 9 shown show VBN cord-015021-pol2qm74 850 10 to to TO cord-015021-pol2qm74 850 11 be be VB cord-015021-pol2qm74 850 12 protective protective JJ cord-015021-pol2qm74 850 13 against against IN cord-015021-pol2qm74 850 14 BT BT NNP cord-015021-pol2qm74 850 15 received receive VBD cord-015021-pol2qm74 850 16 the the DT cord-015021-pol2qm74 850 17 amount amount NN cord-015021-pol2qm74 850 18 of of IN cord-015021-pol2qm74 850 19 non non JJ cord-015021-pol2qm74 850 20 - - JJ cord-015021-pol2qm74 850 21 fermentable fermentable JJ cord-015021-pol2qm74 850 22 fiber fiber NN cord-015021-pol2qm74 850 23 of of IN cord-015021-pol2qm74 850 24 that that DT cord-015021-pol2qm74 850 25 chow chow NN cord-015021-pol2qm74 850 26 regimen regimen NN cord-015021-pol2qm74 850 27 during during IN cord-015021-pol2qm74 850 28 IV IV NNP cord-015021-pol2qm74 850 29 - - HYPH cord-015021-pol2qm74 850 30 TPN TPN NNP cord-015021-pol2qm74 850 31 feeding feeding NN cord-015021-pol2qm74 850 32 and and CC cord-015021-pol2qm74 850 33 BT BT NNP cord-015021-pol2qm74 850 34 was be VBD cord-015021-pol2qm74 850 35 studied study VBN cord-015021-pol2qm74 850 36 . . . cord-015021-pol2qm74 851 1 4 4 CD cord-015021-pol2qm74 851 2 5,5 5,5 CD cord-015021-pol2qm74 851 3 + + CD cord-015021-pol2qm74 851 4 0,9 0,9 CD cord-015021-pol2qm74 851 5 4 4 CD cord-015021-pol2qm74 851 6 12 12 CD cord-015021-pol2qm74 852 1 23,9 23,9 CD cord-015021-pol2qm74 852 2 -2,3 -2,3 SYM cord-015021-pol2qm74 852 3 16 16 CD cord-015021-pol2qm74 852 4 , , , cord-015021-pol2qm74 852 5 7 7 CD cord-015021-pol2qm74 852 6 2/12 2/12 CD cord-015021-pol2qm74 852 7 63 63 CD cord-015021-pol2qm74 852 8 + + CD cord-015021-pol2qm74 853 1 11 11 CD cord-015021-pol2qm74 853 2 125~1 125~1 CD cord-015021-pol2qm74 854 1 " " `` cord-015021-pol2qm74 854 2 7,7-+0,7 7,7-+0,7 NNP cord-015021-pol2qm74 854 3 6,7-+1 6,7-+1 CD cord-015021-pol2qm74 855 1 5 5 CD cord-015021-pol2qm74 855 2 12 12 CD cord-015021-pol2qm74 855 3 24~6 24~6 CD cord-015021-pol2qm74 855 4 -3,5 -3,5 SYM cord-015021-pol2qm74 855 5 67 67 CD cord-015021-pol2qm74 855 6 8/12 8/12 CD cord-015021-pol2qm74 856 1 241+~243 241+~243 CD cord-015021-pol2qm74 856 2 170 170 CD cord-015021-pol2qm74 856 3 + + SYM cord-015021-pol2qm74 856 4 163 163 CD cord-015021-pol2qm74 856 5 8_+0,7 8_+0,7 CD cord-015021-pol2qm74 856 6 7 7 CD cord-015021-pol2qm74 857 1 +1,1 +1,1 NNP cord-015021-pol2qm74 857 2 6 6 CD cord-015021-pol2qm74 857 3 18 18 CD cord-015021-pol2qm74 857 4 25 25 CD cord-015021-pol2qm74 857 5 , , , cord-015021-pol2qm74 857 6 5 5 CD cord-015021-pol2qm74 857 7 -4 -4 ADD cord-015021-pol2qm74 858 1 88,8 88,8 CD cord-015021-pol2qm74 858 2 16118 16118 CD cord-015021-pol2qm74 859 1 2061-+3224 2061-+3224 CD cord-015021-pol2qm74 859 2 2211 2211 CD cord-015021-pol2qm74 859 3 + + CD cord-015021-pol2qm74 859 4 4015 4015 CD cord-015021-pol2qm74 859 5 8,4~0,7 8,4~0,7 CD cord-015021-pol2qm74 859 6 8,1-+1~1 8,1-+1~1 CD cord-015021-pol2qm74 860 1 Conclusions conclusion NNS cord-015021-pol2qm74 860 2 : : : cord-015021-pol2qm74 861 1 The the DT cord-015021-pol2qm74 861 2 administration administration NN cord-015021-pol2qm74 861 3 of of IN cord-015021-pol2qm74 861 4 30 30 CD cord-015021-pol2qm74 861 5 % % NN cord-015021-pol2qm74 861 6 of of IN cord-015021-pol2qm74 861 7 DRCI DRCI NNP cord-015021-pol2qm74 861 8 by by IN cord-015021-pol2qm74 861 9 chow chow NN cord-015021-pol2qm74 861 10 feeding feeding NN cord-015021-pol2qm74 861 11 during during IN cord-015021-pol2qm74 861 12 IV IV NNP cord-015021-pol2qm74 861 13 - - HYPH cord-015021-pol2qm74 861 14 TPN TPN NNP cord-015021-pol2qm74 861 15 significantly significantly RB cord-015021-pol2qm74 861 16 reduced reduce VBD cord-015021-pol2qm74 861 17 the the DT cord-015021-pol2qm74 861 18 incidence incidence NN cord-015021-pol2qm74 861 19 of of IN cord-015021-pol2qm74 861 20 BT BT NNP cord-015021-pol2qm74 861 21 and and CC cord-015021-pol2qm74 861 22 maintained maintain VBD cord-015021-pol2qm74 861 23 gut gut NN cord-015021-pol2qm74 861 24 barrier barrier NN cord-015021-pol2qm74 861 25 function function NN cord-015021-pol2qm74 861 26 . . . cord-015021-pol2qm74 862 1 The the DT cord-015021-pol2qm74 862 2 addition addition NN cord-015021-pol2qm74 862 3 of of IN cord-015021-pol2qm74 862 4 the the DT cord-015021-pol2qm74 862 5 respective respective JJ cord-015021-pol2qm74 862 6 amount amount NN cord-015021-pol2qm74 862 7 of of IN cord-015021-pol2qm74 862 8 dietary dietary JJ cord-015021-pol2qm74 862 9 fiber fiber NN cord-015021-pol2qm74 862 10 of of IN cord-015021-pol2qm74 862 11 this this DT cord-015021-pol2qm74 862 12 group group NN cord-015021-pol2qm74 862 13 did do VBD cord-015021-pol2qm74 862 14 not not RB cord-015021-pol2qm74 862 15 prevent prevent VB cord-015021-pol2qm74 862 16 IV IV NNP cord-015021-pol2qm74 862 17 - - HYPH cord-015021-pol2qm74 862 18 TPN TPN NNP cord-015021-pol2qm74 862 19 - - HYPH cord-015021-pol2qm74 862 20 indueed indueed NN cord-015021-pol2qm74 862 21 BT BT NNP cord-015021-pol2qm74 862 22 . . . cord-015021-pol2qm74 863 1 Dr. Dr. NNP cord-015021-pol2qm74 863 2 med med NNP cord-015021-pol2qm74 863 3 . . . cord-015021-pol2qm74 863 4 M M NNP cord-015021-pol2qm74 863 5 Naruhn Naruhn NNP cord-015021-pol2qm74 863 6 . . . cord-015021-pol2qm74 864 1 , , , cord-015021-pol2qm74 864 2 Dep Dep NNP cord-015021-pol2qm74 864 3 . . NNP cord-015021-pol2qm74 864 4 of of IN cord-015021-pol2qm74 864 5 General General NNP cord-015021-pol2qm74 864 6 Surgery Surgery NNP cord-015021-pol2qm74 864 7 , , , cord-015021-pol2qm74 864 8 Eberhard Eberhard NNP cord-015021-pol2qm74 864 9 - - HYPH cord-015021-pol2qm74 864 10 Karls Karls NNP cord-015021-pol2qm74 864 11 - - HYPH cord-015021-pol2qm74 864 12 University University NNP cord-015021-pol2qm74 864 13 , , , cord-015021-pol2qm74 864 14 Hoppe Hoppe NNP cord-015021-pol2qm74 864 15 - - HYPH cord-015021-pol2qm74 864 16 Seyler Seyler NNP cord-015021-pol2qm74 864 17 - - HYPH cord-015021-pol2qm74 864 18 Str Str NNP cord-015021-pol2qm74 864 19 . . . cord-015021-pol2qm74 864 20 3 3 CD cord-015021-pol2qm74 865 1 Previous previous JJ cord-015021-pol2qm74 865 2 experimental experimental JJ cord-015021-pol2qm74 865 3 studies study NNS cord-015021-pol2qm74 865 4 have have VBP cord-015021-pol2qm74 865 5 suggested suggest VBN cord-015021-pol2qm74 865 6 that that IN cord-015021-pol2qm74 865 7 a a DT cord-015021-pol2qm74 865 8 disturbed disturbed JJ cord-015021-pol2qm74 865 9 ecology ecology NN cord-015021-pol2qm74 865 10 of of IN cord-015021-pol2qm74 865 11 the the DT cord-015021-pol2qm74 865 12 enteric enteric JJ cord-015021-pol2qm74 865 13 bacterial bacterial JJ cord-015021-pol2qm74 865 14 population population NN cord-015021-pol2qm74 865 15 might may MD cord-015021-pol2qm74 865 16 contribute contribute VB cord-015021-pol2qm74 865 17 to to IN cord-015021-pol2qm74 865 18 the the DT cord-015021-pol2qm74 865 19 development development NN cord-015021-pol2qm74 865 20 of of IN cord-015021-pol2qm74 865 21 bacterial bacterial JJ cord-015021-pol2qm74 865 22 translocation translocation NN cord-015021-pol2qm74 865 23 from from IN cord-015021-pol2qm74 865 24 the the DT cord-015021-pol2qm74 865 25 gut gut NN cord-015021-pol2qm74 865 26 in in IN cord-015021-pol2qm74 865 27 acute acute JJ cord-015021-pol2qm74 865 28 liver liver NN cord-015021-pol2qm74 865 29 failure failure NN cord-015021-pol2qm74 865 30 ( ( -LRB- cord-015021-pol2qm74 865 31 ALF ALF NNP cord-015021-pol2qm74 865 32 ) ) -RRB- cord-015021-pol2qm74 865 33 . . . cord-015021-pol2qm74 866 1 In in IN cord-015021-pol2qm74 866 2 the the DT cord-015021-pol2qm74 866 3 present present JJ cord-015021-pol2qm74 866 4 study study NN cord-015021-pol2qm74 866 5 , , , cord-015021-pol2qm74 866 6 the the DT cord-015021-pol2qm74 866 7 effect effect NN cord-015021-pol2qm74 866 8 of of IN cord-015021-pol2qm74 866 9 oral oral JJ cord-015021-pol2qm74 866 10 administration administration NN cord-015021-pol2qm74 866 11 of of IN cord-015021-pol2qm74 866 12 Lactobacillus Lactobacillus NNP cord-015021-pol2qm74 866 13 reuteri reuteri NN cord-015021-pol2qm74 866 14 R2LC r2lc NN cord-015021-pol2qm74 866 15 and and CC cord-015021-pol2qm74 866 16 oat oat NN cord-015021-pol2qm74 866 17 fiber fiber NN cord-015021-pol2qm74 866 18 on on IN cord-015021-pol2qm74 866 19 bacterial bacterial JJ cord-015021-pol2qm74 866 20 overgrowth overgrowth NN cord-015021-pol2qm74 866 21 and and CC cord-015021-pol2qm74 866 22 translocation translocation NN cord-015021-pol2qm74 866 23 was be VBD cord-015021-pol2qm74 866 24 investigated investigate VBN cord-015021-pol2qm74 866 25 in in IN cord-015021-pol2qm74 866 26 rats rat NNS cord-015021-pol2qm74 866 27 with with IN cord-015021-pol2qm74 866 28 acute acute JJ cord-015021-pol2qm74 866 29 liver liver NN cord-015021-pol2qm74 866 30 failure failure NN cord-015021-pol2qm74 866 31 induced induce VBN cord-015021-pol2qm74 866 32 by by IN cord-015021-pol2qm74 866 33 subtotal subtotal NN cord-015021-pol2qm74 866 34 ( ( -LRB- cord-015021-pol2qm74 866 35 90 90 CD cord-015021-pol2qm74 866 36 % % NN cord-015021-pol2qm74 866 37 ) ) -RRB- cord-015021-pol2qm74 866 38 liver liver NN cord-015021-pol2qm74 866 39 resection resection NN cord-015021-pol2qm74 866 40 . . . cord-015021-pol2qm74 867 1 The the DT cord-015021-pol2qm74 867 2 oatmeal oatmeal NN cord-015021-pol2qm74 867 3 soup soup NN cord-015021-pol2qm74 867 4 base base NN cord-015021-pol2qm74 867 5 was be VBD cord-015021-pol2qm74 867 6 anaerobically anaerobically RB cord-015021-pol2qm74 867 7 inoculated inoculate VBN cord-015021-pol2qm74 867 8 with with IN cord-015021-pol2qm74 867 9 lactobacillae lactobacillae NNS cord-015021-pol2qm74 867 10 and and CC cord-015021-pol2qm74 867 11 fermented ferment VBN cord-015021-pol2qm74 867 12 for for IN cord-015021-pol2qm74 867 13 15 15 CD cord-015021-pol2qm74 867 14 hours hour NNS cord-015021-pol2qm74 867 15 , , , cord-015021-pol2qm74 867 16 after after IN cord-015021-pol2qm74 867 17 which which WDT cord-015021-pol2qm74 867 18 the the DT cord-015021-pol2qm74 867 19 animals animal NNS cord-015021-pol2qm74 867 20 were be VBD cord-015021-pol2qm74 867 21 fed feed VBN cord-015021-pol2qm74 867 22 with with IN cord-015021-pol2qm74 867 23 either either CC cord-015021-pol2qm74 867 24 fermented fermented JJ cord-015021-pol2qm74 867 25 or or CC cord-015021-pol2qm74 867 26 unfermented unfermented JJ cord-015021-pol2qm74 867 27 oatmeal oatmeal NN cord-015021-pol2qm74 867 28 or or CC cord-015021-pol2qm74 867 29 saline saline NN cord-015021-pol2qm74 867 30 daily daily RB cord-015021-pol2qm74 867 31 for for IN cord-015021-pol2qm74 867 32 6 6 CD cord-015021-pol2qm74 867 33 days day NNS cord-015021-pol2qm74 867 34 prior prior RB cord-015021-pol2qm74 867 35 to to IN cord-015021-pol2qm74 867 36 the the DT cord-015021-pol2qm74 867 37 operation operation NN cord-015021-pol2qm74 867 38 . . . cord-015021-pol2qm74 868 1 Bacterial bacterial JJ cord-015021-pol2qm74 868 2 translocation translocation NN cord-015021-pol2qm74 868 3 to to IN cord-015021-pol2qm74 868 4 mesenteric mesenteric JJ cord-015021-pol2qm74 868 5 lymph lymph NN cord-015021-pol2qm74 868 6 nodes node NNS cord-015021-pol2qm74 868 7 ( ( -LRB- cord-015021-pol2qm74 868 8 MLN mln NN cord-015021-pol2qm74 868 9 ) ) -RRB- cord-015021-pol2qm74 868 10 and and CC cord-015021-pol2qm74 868 11 the the DT cord-015021-pol2qm74 868 12 systemic systemic JJ cord-015021-pol2qm74 868 13 circulation circulation NN cord-015021-pol2qm74 868 14 was be VBD cord-015021-pol2qm74 868 15 determined determine VBN cord-015021-pol2qm74 868 16 , , , cord-015021-pol2qm74 868 17 as as RB cord-015021-pol2qm74 868 18 well well RB cord-015021-pol2qm74 868 19 as as IN cord-015021-pol2qm74 868 20 the the DT cord-015021-pol2qm74 868 21 intestinal intestinal JJ cord-015021-pol2qm74 868 22 bacterial bacterial JJ cord-015021-pol2qm74 868 23 flora flora NNS cord-015021-pol2qm74 868 24 and and CC cord-015021-pol2qm74 868 25 enterocyte enterocyte NNP cord-015021-pol2qm74 868 26 protein protein NN cord-015021-pol2qm74 868 27 content content NN cord-015021-pol2qm74 868 28 . . . cord-015021-pol2qm74 869 1 The the DT cord-015021-pol2qm74 869 2 incidence incidence NN cord-015021-pol2qm74 869 3 of of IN cord-015021-pol2qm74 869 4 bacterial bacterial JJ cord-015021-pol2qm74 869 5 translocstion translocstion NN cord-015021-pol2qm74 869 6 to to IN cord-015021-pol2qm74 869 7 the the DT cord-015021-pol2qm74 869 8 systemic systemic JJ cord-015021-pol2qm74 869 9 circulation circulation NN cord-015021-pol2qm74 869 10 was be VBD cord-015021-pol2qm74 869 11 nit nit NN cord-015021-pol2qm74 869 12 in in IN cord-015021-pol2qm74 869 13 rats rat NNS cord-015021-pol2qm74 869 14 subjected subject VBN cord-015021-pol2qm74 869 15 to to IN cord-015021-pol2qm74 869 16 sham sham JJ cord-015021-pol2qm74 869 17 operation operation NN cord-015021-pol2qm74 869 18 and and CC cord-015021-pol2qm74 869 19 saline saline NN cord-015021-pol2qm74 869 20 treatment treatment NN cord-015021-pol2qm74 869 21 and and CC cord-015021-pol2qm74 869 22 17 17 CD cord-015021-pol2qm74 869 23 % % NN cord-015021-pol2qm74 869 24 in in IN cord-015021-pol2qm74 869 25 animals animal NNS cord-015021-pol2qm74 869 26 subjected subject VBN cord-015021-pol2qm74 869 27 to to IN cord-015021-pol2qm74 869 28 90 90 CD cord-015021-pol2qm74 869 29 % % NN cord-015021-pol2qm74 869 30 bepatectomy bepatectomy NN cord-015021-pol2qm74 869 31 and and CC cord-015021-pol2qm74 869 32 lreatment lreatment NN cord-015021-pol2qm74 869 33 with with IN cord-015021-pol2qm74 869 34 fermented ferment VBN cord-015021-pol2qm74 869 35 oatmeal oatmeal NN cord-015021-pol2qm74 869 36 , , , cord-015021-pol2qm74 869 37 while while IN cord-015021-pol2qm74 869 38 80 80 CD cord-015021-pol2qm74 869 39 - - SYM cord-015021-pol2qm74 869 40 90 90 CD cord-015021-pol2qm74 869 41 % % NN cord-015021-pol2qm74 869 42 and and CC cord-015021-pol2qm74 869 43 34 34 CD cord-015021-pol2qm74 869 44 - - SYM cord-015021-pol2qm74 869 45 50 50 CD cord-015021-pol2qm74 869 46 % % NN cord-015021-pol2qm74 869 47 , , , cord-015021-pol2qm74 869 48 respectively respectively RB cord-015021-pol2qm74 869 49 , , , cord-015021-pol2qm74 869 50 in in IN cord-015021-pol2qm74 869 51 rats rat NNS cord-015021-pol2qm74 869 52 subjected subject VBN cord-015021-pol2qm74 869 53 to to IN cord-015021-pol2qm74 869 54 hepatectomy hepatectomy NN cord-015021-pol2qm74 869 55 and and CC cord-015021-pol2qm74 869 56 treatment treatment NN cord-015021-pol2qm74 869 57 with with IN cord-015021-pol2qm74 869 58 either either CC cord-015021-pol2qm74 869 59 saline saline NN cord-015021-pol2qm74 869 60 or or CC cord-015021-pol2qm74 869 61 unfermented unfermented JJ cord-015021-pol2qm74 869 62 oatmeal oatmeal NN cord-015021-pol2qm74 869 63 . . . cord-015021-pol2qm74 870 1 Only only RB cord-015021-pol2qm74 870 2 one one CD cord-015021-pol2qm74 870 3 rat rat NN cord-015021-pol2qm74 870 4 with with IN cord-015021-pol2qm74 870 5 fermented ferment VBN cord-015021-pol2qm74 870 6 oatmeal oatmeal NN cord-015021-pol2qm74 870 7 demonstrated demonstrate VBD cord-015021-pol2qm74 870 8 bacterial bacterial JJ cord-015021-pol2qm74 870 9 growth growth NN cord-015021-pol2qm74 870 10 in in IN cord-015021-pol2qm74 870 11 MLN mln NN cord-015021-pol2qm74 870 12 ( ( -LRB- cord-015021-pol2qm74 870 13 p p NN cord-015021-pol2qm74 870 14 < < XX cord-015021-pol2qm74 870 15 0.05 0.05 CD cord-015021-pol2qm74 870 16 vs vs IN cord-015021-pol2qm74 870 17 hepatectomy hepatectomy NN cord-015021-pol2qm74 870 18 and and CC cord-015021-pol2qm74 870 19 treatment treatment NN cord-015021-pol2qm74 870 20 with with IN cord-015021-pol2qm74 870 21 saline saline NN cord-015021-pol2qm74 870 22 or or CC cord-015021-pol2qm74 870 23 unfermented unfermented JJ cord-015021-pol2qm74 870 24 oatmeal oatmeal NN cord-015021-pol2qm74 870 25 ) ) -RRB- cord-015021-pol2qm74 870 26 . . . cord-015021-pol2qm74 871 1 The the DT cord-015021-pol2qm74 871 2 enterocyte enterocyte NNP cord-015021-pol2qm74 871 3 protein protein NN cord-015021-pol2qm74 871 4 content content NN cord-015021-pol2qm74 871 5 significantly significantly RB cord-015021-pol2qm74 871 6 decreased decrease VBD cord-015021-pol2qm74 871 7 ( ( -LRB- cord-015021-pol2qm74 871 8 p p NN cord-015021-pol2qm74 871 9 < < XX cord-015021-pol2qm74 871 10 0.01 0.01 CD cord-015021-pol2qm74 871 11 ) ) -RRB- cord-015021-pol2qm74 871 12 in in IN cord-015021-pol2qm74 871 13 salinetreated salinetreate VBN cord-015021-pol2qm74 871 14 animals animal NNS cord-015021-pol2qm74 871 15 following follow VBG cord-015021-pol2qm74 871 16 90 90 CD cord-015021-pol2qm74 871 17 % % NN cord-015021-pol2qm74 871 18 hepatectomy hepatectomy NN cord-015021-pol2qm74 871 19 , , , cord-015021-pol2qm74 871 20 while while IN cord-015021-pol2qm74 871 21 there there EX cord-015021-pol2qm74 871 22 was be VBD cord-015021-pol2qm74 871 23 no no DT cord-015021-pol2qm74 871 24 significant significant JJ cord-015021-pol2qm74 871 25 difference difference NN cord-015021-pol2qm74 871 26 between between IN cord-015021-pol2qm74 871 27 bepatectomized bepatectomized JJ cord-015021-pol2qm74 871 28 animals animal NNS cord-015021-pol2qm74 871 29 with with IN cord-015021-pol2qm74 871 30 oral oral JJ cord-015021-pol2qm74 871 31 administration administration NN cord-015021-pol2qm74 871 32 of of IN cord-015021-pol2qm74 871 33 fermented ferment VBN cord-015021-pol2qm74 871 34 or or CC cord-015021-pol2qm74 871 35 unfermented unfermented JJ cord-015021-pol2qm74 871 36 oatmeal oatmeal NN cord-015021-pol2qm74 871 37 . . . cord-015021-pol2qm74 872 1 The the DT cord-015021-pol2qm74 872 2 number number NN cord-015021-pol2qm74 872 3 of of IN cord-015021-pol2qm74 872 4 anaerobic anaerobic JJ cord-015021-pol2qm74 872 5 bacteria bacteria NNS cord-015021-pol2qm74 872 6 , , , cord-015021-pol2qm74 872 7 Gram gram NN cord-015021-pol2qm74 872 8 - - HYPH cord-015021-pol2qm74 872 9 negative negative JJ cord-015021-pol2qm74 872 10 anaerobes anaerobe NNS cord-015021-pol2qm74 872 11 and and CC cord-015021-pol2qm74 872 12 Lactobacillus lactobacillus NN cord-015021-pol2qm74 872 13 significantly significantly RB cord-015021-pol2qm74 872 14 decreased decrease VBD cord-015021-pol2qm74 872 15 and and CC cord-015021-pol2qm74 872 16 the the DT cord-015021-pol2qm74 872 17 number number NN cord-015021-pol2qm74 872 18 of of IN cord-015021-pol2qm74 872 19 E.cnli E.cnli NNS cord-015021-pol2qm74 872 20 increased increase VBD cord-015021-pol2qm74 872 21 in in IN cord-015021-pol2qm74 872 22 the the DT cord-015021-pol2qm74 872 23 distal distal JJ cord-015021-pol2qm74 872 24 small small JJ cord-015021-pol2qm74 872 25 intestine intestine NN cord-015021-pol2qm74 872 26 and and CC cord-015021-pol2qm74 872 27 colon colon NN cord-015021-pol2qm74 872 28 in in IN cord-015021-pol2qm74 872 29 hepatectomized hepatectomized JJ cord-015021-pol2qm74 872 30 animals animal NNS cord-015021-pol2qm74 872 31 with with IN cord-015021-pol2qm74 872 32 enteral enteral JJ cord-015021-pol2qm74 872 33 saline saline NN cord-015021-pol2qm74 872 34 or or CC cord-015021-pol2qm74 872 35 unfermented unfermented JJ cord-015021-pol2qm74 872 36 oatmeal oatmeal NN cord-015021-pol2qm74 872 37 as as IN cord-015021-pol2qm74 872 38 compared compare VBN cord-015021-pol2qm74 872 39 with with IN cord-015021-pol2qm74 872 40 animals animal NNS cord-015021-pol2qm74 872 41 subjected subject VBN cord-015021-pol2qm74 872 42 to to IN cord-015021-pol2qm74 872 43 sham sham JJ cord-015021-pol2qm74 872 44 operation operation NN cord-015021-pol2qm74 872 45 or or CC cord-015021-pol2qm74 872 46 bepatectomy bepatectomy NN cord-015021-pol2qm74 872 47 with with IN cord-015021-pol2qm74 872 48 fermented ferment VBN cord-015021-pol2qm74 872 49 oatmeal oatmeal NN cord-015021-pol2qm74 872 50 . . . cord-015021-pol2qm74 873 1 Our -PRON- PRP$ cord-015021-pol2qm74 873 2 results result NNS cord-015021-pol2qm74 873 3 thus thus RB cord-015021-pol2qm74 873 4 show show VBP cord-015021-pol2qm74 873 5 that that IN cord-015021-pol2qm74 873 6 the the DT cord-015021-pol2qm74 873 7 occurrence occurrence NN cord-015021-pol2qm74 873 8 of of IN cord-015021-pol2qm74 873 9 bacterial bacterial JJ cord-015021-pol2qm74 873 10 translocatiou translocatiou NN cord-015021-pol2qm74 873 11 from from IN cord-015021-pol2qm74 873 12 the the DT cord-015021-pol2qm74 873 13 gut gut NN cord-015021-pol2qm74 873 14 in in IN cord-015021-pol2qm74 873 15 90 90 CD cord-015021-pol2qm74 873 16 % % NN cord-015021-pol2qm74 873 17 hepatectomy hepatectomy NN cord-015021-pol2qm74 873 18 - - HYPH cord-015021-pol2qm74 873 19 induced induce VBN cord-015021-pol2qm74 873 20 ALF ALF NNP cord-015021-pol2qm74 873 21 could could MD cord-015021-pol2qm74 873 22 be be VB cord-015021-pol2qm74 873 23 prevented prevent VBN cord-015021-pol2qm74 873 24 by by IN cord-015021-pol2qm74 873 25 enteral enteral NNP cord-015021-pol2qm74 873 26 administration administration NN cord-015021-pol2qm74 873 27 of of IN cord-015021-pol2qm74 873 28 fermented ferment VBN cord-015021-pol2qm74 873 29 oatmeal oatmeal NN cord-015021-pol2qm74 873 30 , , , cord-015021-pol2qm74 873 31 maybe maybe RB cord-015021-pol2qm74 873 32 partly partly RB cord-015021-pol2qm74 873 33 due due JJ cord-015021-pol2qm74 873 34 to to IN cord-015021-pol2qm74 873 35 a a DT cord-015021-pol2qm74 873 36 positive positive JJ cord-015021-pol2qm74 873 37 effect effect NN cord-015021-pol2qm74 873 38 on on IN cord-015021-pol2qm74 873 39 the the DT cord-015021-pol2qm74 873 40 enteric enteric JJ cord-015021-pol2qm74 873 41 bacterial bacterial JJ cord-015021-pol2qm74 873 42 ecology ecology NN cord-015021-pol2qm74 873 43 . . . cord-015021-pol2qm74 874 1 190_+20 190_+20 CD cord-015021-pol2qm74 875 1 " " `` cord-015021-pol2qm74 875 2 16+_3 16+_3 CD cord-015021-pol2qm74 876 1 " " `` cord-015021-pol2qm74 876 2 11.7 11.7 CD cord-015021-pol2qm74 876 3 " " '' cord-015021-pol2qm74 876 4 Data= Data= NNS cord-015021-pol2qm74 877 1 Mean_+SD mean_+sd RB cord-015021-pol2qm74 877 2 , , , cord-015021-pol2qm74 877 3 * * NFP cord-015021-pol2qm74 877 4 stats stat VBZ cord-015021-pol2qm74 877 5 ANOVA ANOVA NNP cord-015021-pol2qm74 877 6 P<0.05 P<0.05 NNS cord-015021-pol2qm74 877 7 vs vs IN cord-015021-pol2qm74 877 8 control control NN cord-015021-pol2qm74 877 9 . . . cord-015021-pol2qm74 878 1 L+air l+air NN cord-015021-pol2qm74 878 2 and and CC cord-015021-pol2qm74 878 3 lap lap NN cord-015021-pol2qm74 878 4 groups group NNS cord-015021-pol2qm74 878 5 , , , cord-015021-pol2qm74 878 6 both both DT cord-015021-pol2qm74 878 7 exposed expose VBN cord-015021-pol2qm74 878 8 to to IN cord-015021-pol2qm74 878 9 exogenous exogenous JJ cord-015021-pol2qm74 878 10 I.PS i.ps NN cord-015021-pol2qm74 878 11 shnwm shnwm NN cord-015021-pol2qm74 878 12 : : : cord-015021-pol2qm74 878 13 t t NNP cord-015021-pol2qm74 878 14 m m NNP cord-015021-pol2qm74 878 15 significant significant JJ cord-015021-pol2qm74 878 16 increase increase NN cord-015021-pol2qm74 878 17 ( ( -LRB- cord-015021-pol2qm74 878 18 p<.05 p<.05 NNP cord-015021-pol2qm74 878 19 ) ) -RRB- cord-015021-pol2qm74 878 20 in in IN cord-015021-pol2qm74 878 21 LPS LPS NNP cord-015021-pol2qm74 878 22 gut gut NN cord-015021-pol2qm74 878 23 translocation translocation NN cord-015021-pol2qm74 878 24 compared compare VBN cord-015021-pol2qm74 878 25 to to IN cord-015021-pol2qm74 878 26 control control NN cord-015021-pol2qm74 878 27 and and CC cord-015021-pol2qm74 878 28 L+CO2 L+CO2 NNP cord-015021-pol2qm74 878 29 . . . cord-015021-pol2qm74 879 1 This this DT cord-015021-pol2qm74 879 2 correlated correlate VBD cord-015021-pol2qm74 879 3 with with IN cord-015021-pol2qm74 879 4 a a DT cord-015021-pol2qm74 879 5 significant significant JJ cord-015021-pol2qm74 879 6 increase increase NN cord-015021-pol2qm74 879 7 in in IN cord-015021-pol2qm74 879 8 peritoneal peritoneal JJ cord-015021-pol2qm74 879 9 inflammatory inflammatory JJ cord-015021-pol2qm74 879 10 responses response NNS cord-015021-pol2qm74 879 11 ( ( -LRB- cord-015021-pol2qm74 879 12 O2-,TNF o2-,tnf NN cord-015021-pol2qm74 879 13 ) ) -RRB- cord-015021-pol2qm74 879 14 above above IN cord-015021-pol2qm74 879 15 that that DT cord-015021-pol2qm74 879 16 of of IN cord-015021-pol2qm74 879 17 the the DT cord-015021-pol2qm74 879 18 control control NN cord-015021-pol2qm74 879 19 and and CC cord-015021-pol2qm74 879 20 L+CO2 L+CO2 NNP cord-015021-pol2qm74 879 21 groups group NNS cord-015021-pol2qm74 879 22 , , , cord-015021-pol2qm74 879 23 while while IN cord-015021-pol2qm74 879 24 Mac-1 Mac-1 NNP cord-015021-pol2qm74 879 25 and and CC cord-015021-pol2qm74 879 26 CR3 CR3 NNP cord-015021-pol2qm74 879 27 opsonized opsonize VBN cord-015021-pol2qm74 879 28 phagocytosis phagocytosis NN cord-015021-pol2qm74 879 29 were be VBD cord-015021-pol2qm74 879 30 significantly significantly RB cord-015021-pol2qm74 879 31 impaired impair VBN cord-015021-pol2qm74 879 32 . . . cord-015021-pol2qm74 880 1 The the DT cord-015021-pol2qm74 880 2 absence absence NN cord-015021-pol2qm74 880 3 of of IN cord-015021-pol2qm74 880 4 significant significant JJ cord-015021-pol2qm74 880 5 differences difference NNS cord-015021-pol2qm74 880 6 between between IN cord-015021-pol2qm74 880 7 L+air l+air NN cord-015021-pol2qm74 880 8 and and CC cord-015021-pol2qm74 880 9 lap lap NN cord-015021-pol2qm74 880 10 groups group NNS cord-015021-pol2qm74 880 11 indicates indicate VBZ cord-015021-pol2qm74 880 12 that that IN cord-015021-pol2qm74 880 13 LPS LPS NNP cord-015021-pol2qm74 880 14 rather rather RB cord-015021-pol2qm74 880 15 than than IN cord-015021-pol2qm74 880 16 wound wound NN cord-015021-pol2qm74 880 17 factors factor NNS cord-015021-pol2qm74 880 18 is be VBZ cord-015021-pol2qm74 880 19 the the DT cord-015021-pol2qm74 880 20 principle principle JJ cord-015021-pol2qm74 880 21 mediator mediator NN cord-015021-pol2qm74 880 22 . . . cord-015021-pol2qm74 881 1 Thus thus RB cord-015021-pol2qm74 881 2 , , , cord-015021-pol2qm74 881 3 LPS LPS NNP cord-015021-pol2qm74 881 4 plays play VBZ cord-015021-pol2qm74 881 5 a a DT cord-015021-pol2qm74 881 6 significant significant JJ cord-015021-pol2qm74 881 7 role role NN cord-015021-pol2qm74 881 8 in in IN cord-015021-pol2qm74 881 9 regulating regulate VBG cord-015021-pol2qm74 881 10 peritoneal peritoneal JJ cord-015021-pol2qm74 881 11 responses response NNS cord-015021-pol2qm74 881 12 in in IN cord-015021-pol2qm74 881 13 the the DT cord-015021-pol2qm74 881 14 early early JJ cord-015021-pol2qm74 881 15 post post JJ cord-015021-pol2qm74 881 16 - - JJ cord-015021-pol2qm74 881 17 operative operative JJ cord-015021-pol2qm74 881 18 period period NN cord-015021-pol2qm74 881 19 Dept Dept NNP cord-015021-pol2qm74 881 20 of of IN cord-015021-pol2qm74 881 21 Surgery Surgery NNP cord-015021-pol2qm74 881 22 , , , cord-015021-pol2qm74 881 23 RCSI RCSI NNP cord-015021-pol2qm74 881 24 , , , cord-015021-pol2qm74 881 25 Beaumont Beaumont NNP cord-015021-pol2qm74 881 26 Hospital Hospital NNP cord-015021-pol2qm74 881 27 , , , cord-015021-pol2qm74 881 28 Dublin Dublin NNP cord-015021-pol2qm74 881 29 9 9 CD cord-015021-pol2qm74 881 30 , , , cord-015021-pol2qm74 881 31 Ireland Ireland NNP cord-015021-pol2qm74 881 32 Brlke Brlke NNP cord-015021-pol2qm74 881 33 E E NNP cord-015021-pol2qm74 881 34 , , , cord-015021-pol2qm74 881 35 Berger Berger NNP cord-015021-pol2qm74 881 36 D D NNP cord-015021-pol2qm74 881 37 , , , cord-015021-pol2qm74 881 38 Staneseu Staneseu NNP cord-015021-pol2qm74 881 39 A A NNP cord-015021-pol2qm74 881 40 , , , cord-015021-pol2qm74 881 41 ButtenschSn ButtenschSn NNP cord-015021-pol2qm74 881 42 K K NNP cord-015021-pol2qm74 881 43 , , , cord-015021-pol2qm74 881 44 Vasilescu Vasilescu NNP cord-015021-pol2qm74 881 45 C C NNP cord-015021-pol2qm74 881 46 , , , cord-015021-pol2qm74 881 47 Seidelmann Seidelmann NNP cord-015021-pol2qm74 881 48 M M NNP cord-015021-pol2qm74 881 49 , , , cord-015021-pol2qm74 881 50 Beger Beger NNP cord-015021-pol2qm74 881 51 HG HG NNP cord-015021-pol2qm74 882 1 In in IN cord-015021-pol2qm74 882 2 32 32 CD cord-015021-pol2qm74 882 3 patients patient NNS cord-015021-pol2qm74 882 4 undergoing undergo VBG cord-015021-pol2qm74 882 5 a a DT cord-015021-pol2qm74 882 6 colonoscopy colonoscopy NN cord-015021-pol2qm74 882 7 , , , cord-015021-pol2qm74 882 8 endotoxin endotoxin NN cord-015021-pol2qm74 882 9 , , , cord-015021-pol2qm74 882 10 endotoxin endotoxin NN cord-015021-pol2qm74 882 11 neutralizing neutralize VBG cord-015021-pol2qm74 882 12 capacity capacity NN cord-015021-pol2qm74 882 13 ( ( -LRB- cord-015021-pol2qm74 882 14 ENC ENC NNP cord-015021-pol2qm74 882 15 ) ) -RRB- cord-015021-pol2qm74 882 16 , , , cord-015021-pol2qm74 882 17 thromboxane thromboxane NN cord-015021-pol2qm74 882 18 B b NN cord-015021-pol2qm74 882 19 o o NN cord-015021-pol2qm74 882 20 ( ( -LRB- cord-015021-pol2qm74 882 21 stabile stabile JJ cord-015021-pol2qm74 882 22 metabolite metabolite NN cord-015021-pol2qm74 882 23 of of IN cord-015021-pol2qm74 882 24 tbmomboxane tbmomboxane NNP cord-015021-pol2qm74 882 25 ~ ~ NFP cord-015021-pol2qm74 882 26 ) ) -RRB- cord-015021-pol2qm74 882 27 , , , cord-015021-pol2qm74 882 28 6-Keto 6-keto CD cord-015021-pol2qm74 882 29 - - HYPH cord-015021-pol2qm74 882 30 prostaglanSin prostaglanSin NNP cord-015021-pol2qm74 882 31 , , , cord-015021-pol2qm74 882 32 leueotriene leueotriene NNP cord-015021-pol2qm74 882 33 C4 C4 NNP cord-015021-pol2qm74 882 34 , , , cord-015021-pol2qm74 882 35 interleukin interleukin NN cord-015021-pol2qm74 882 36 6 6 CD cord-015021-pol2qm74 882 37 and and CC cord-015021-pol2qm74 882 38 the the DT cord-015021-pol2qm74 882 39 incidence incidence NN cord-015021-pol2qm74 882 40 of of IN cord-015021-pol2qm74 882 41 bacteremia bacteremia NN cord-015021-pol2qm74 882 42 were be VBD cord-015021-pol2qm74 882 43 determined determine VBN cord-015021-pol2qm74 882 44 before before RB cord-015021-pol2qm74 882 45 and and CC cord-015021-pol2qm74 882 46 then then RB cord-015021-pol2qm74 882 47 every every DT cord-015021-pol2qm74 882 48 five five CD cord-015021-pol2qm74 882 49 minutes minute NNS cord-015021-pol2qm74 882 50 during during IN cord-015021-pol2qm74 882 51 the the DT cord-015021-pol2qm74 882 52 procedure procedure NN cord-015021-pol2qm74 882 53 . . . cord-015021-pol2qm74 883 1 Twenty twenty CD cord-015021-pol2qm74 883 2 - - HYPH cord-015021-pol2qm74 883 3 one one CD cord-015021-pol2qm74 883 4 of of IN cord-015021-pol2qm74 883 5 32 32 CD cord-015021-pol2qm74 883 6 patients patient NNS cord-015021-pol2qm74 883 7 showed show VBD cord-015021-pol2qm74 883 8 a a DT cord-015021-pol2qm74 883 9 significant significant JJ cord-015021-pol2qm74 883 10 increase increase NN cord-015021-pol2qm74 883 11 of of IN cord-015021-pol2qm74 883 12 endotoxin endotoxin NN cord-015021-pol2qm74 883 13 plasma plasma NN cord-015021-pol2qm74 883 14 levels level NNS cord-015021-pol2qm74 883 15 during during IN cord-015021-pol2qm74 883 16 colonoscopy colonoscopy NN cord-015021-pol2qm74 883 17 ( ( -LRB- cord-015021-pol2qm74 883 18 p=0.003 p=0.003 NNP cord-015021-pol2qm74 883 19 ) ) -RRB- cord-015021-pol2qm74 883 20 , , , cord-015021-pol2qm74 883 21 whereas whereas IN cord-015021-pol2qm74 883 22 only only RB cord-015021-pol2qm74 883 23 one one CD cord-015021-pol2qm74 883 24 patient patient NN cord-015021-pol2qm74 883 25 had have VBD cord-015021-pol2qm74 883 26 a a DT cord-015021-pol2qm74 883 27 positive positive JJ cord-015021-pol2qm74 883 28 blood blood NN cord-015021-pol2qm74 883 29 culture culture NN cord-015021-pol2qm74 883 30 with with IN cord-015021-pol2qm74 883 31 bacteria bacteria NNS cord-015021-pol2qm74 883 32 obviously obviously RB cord-015021-pol2qm74 883 33 derived derive VBN cord-015021-pol2qm74 883 34 from from IN cord-015021-pol2qm74 883 35 the the DT cord-015021-pol2qm74 883 36 gastro gastro JJ cord-015021-pol2qm74 883 37 - - JJ cord-015021-pol2qm74 883 38 intestinal intestinal JJ cord-015021-pol2qm74 883 39 tract tract NN cord-015021-pol2qm74 883 40 . . . cord-015021-pol2qm74 884 1 The the DT cord-015021-pol2qm74 884 2 ENC ENC NNP cord-015021-pol2qm74 884 3 decreased decrease VBD cord-015021-pol2qm74 884 4 significantly significantly RB cord-015021-pol2qm74 884 5 five five CD cord-015021-pol2qm74 884 6 minutes minute NNS cord-015021-pol2qm74 884 7 after after IN cord-015021-pol2qm74 884 8 the the DT cord-015021-pol2qm74 884 9 beginning beginning NN cord-015021-pol2qm74 884 10 of of IN cord-015021-pol2qm74 884 11 eolonoscopy eolonoscopy NN cord-015021-pol2qm74 884 12 and and CC cord-015021-pol2qm74 884 13 was be VBD cord-015021-pol2qm74 884 14 diminished diminish VBN cord-015021-pol2qm74 884 15 further further RB cord-015021-pol2qm74 884 16 thereafter thereafter RB cord-015021-pol2qm74 884 17 . . . cord-015021-pol2qm74 885 1 The the DT cord-015021-pol2qm74 885 2 baseline baseline JJ cord-015021-pol2qm74 885 3 values value NNS cord-015021-pol2qm74 885 4 were be VBD cord-015021-pol2qm74 885 5 reached reach VBN cord-015021-pol2qm74 885 6 after after IN cord-015021-pol2qm74 885 7 24 24 CD cord-015021-pol2qm74 885 8 hours hour NNS cord-015021-pol2qm74 885 9 . . . cord-015021-pol2qm74 886 1 ~hromboxane ~hromboxane NFP cord-015021-pol2qm74 887 1 B b NN cord-015021-pol2qm74 887 2 o o NN cord-015021-pol2qm74 887 3 levels level NNS cord-015021-pol2qm74 887 4 also also RB cord-015021-pol2qm74 887 5 increased increase VBD cord-015021-pol2qm74 887 6 after after IN cord-015021-pol2qm74 887 7 five five CD cord-015021-pol2qm74 887 8 min min NN cord-015021-pol2qm74 887 9 . . . cord-015021-pol2qm74 888 1 from from IN cord-015021-pol2qm74 888 2 89 89 CD cord-015021-pol2qm74 889 1 to to IN cord-015021-pol2qm74 889 2 376 376 CD cord-015021-pol2qm74 889 3 pgYml pgyml NN cord-015021-pol2qm74 889 4 peaking peak VBG cord-015021-pol2qm74 889 5 at at IN cord-015021-pol2qm74 889 6 30 30 CD cord-015021-pol2qm74 889 7 min min NN cord-015021-pol2qm74 889 8 . . . cord-015021-pol2qm74 890 1 with with IN cord-015021-pol2qm74 890 2 1332 1332 CD cord-015021-pol2qm74 890 3 pg pg NNP cord-015021-pol2qm74 890 4 / / SYM cord-015021-pol2qm74 890 5 ml ml NN cord-015021-pol2qm74 890 6 . . . cord-015021-pol2qm74 891 1 6-Keto 6-keto CD cord-015021-pol2qm74 892 1 -prostaglandin -prostaglandin . cord-015021-pol2qm74 893 1 , , , cord-015021-pol2qm74 893 2 leucotriene leucotriene NNP cord-015021-pol2qm74 893 3 C C NNP cord-015021-pol2qm74 893 4 4 4 CD cord-015021-pol2qm74 893 5 , , , cord-015021-pol2qm74 893 6 Ii-6 Ii-6 NNP cord-015021-pol2qm74 893 7 and and CC cord-015021-pol2qm74 893 8 CRP CRP NNP cord-015021-pol2qm74 893 9 remained remain VBD cord-015021-pol2qm74 893 10 unchanged unchanged JJ cord-015021-pol2qm74 893 11 . . . cord-015021-pol2qm74 894 1 A a DT cord-015021-pol2qm74 894 2 control control NN cord-015021-pol2qm74 894 3 group group NN cord-015021-pol2qm74 894 4 of of IN cord-015021-pol2qm74 894 5 i0 i0 NN cord-015021-pol2qm74 894 6 volunteers volunteer NNS cord-015021-pol2qm74 894 7 who who WP cord-015021-pol2qm74 894 8 were be VBD cord-015021-pol2qm74 894 9 not not RB cord-015021-pol2qm74 894 10 subjected subject VBN cord-015021-pol2qm74 894 11 to to IN cord-015021-pol2qm74 894 12 endoscopy endoscopy NN cord-015021-pol2qm74 894 13 , , , cord-015021-pol2qm74 894 14 were be VBD cord-015021-pol2qm74 894 15 prepared prepare VBN cord-015021-pol2qm74 894 16 for for IN cord-015021-pol2qm74 894 17 eolonoscopy eolonoscopy NNP cord-015021-pol2qm74 894 18 by by IN cord-015021-pol2qm74 894 19 orthograde orthograde NNP cord-015021-pol2qm74 894 20 lavage lavage NN cord-015021-pol2qm74 894 21 . . . cord-015021-pol2qm74 895 1 The the DT cord-015021-pol2qm74 895 2 blood blood NN cord-015021-pol2qm74 895 3 sampling sampling NN cord-015021-pol2qm74 895 4 procedure procedure NN cord-015021-pol2qm74 895 5 remained remain VBD cord-015021-pol2qm74 895 6 identical identical JJ cord-015021-pol2qm74 895 7 . . . cord-015021-pol2qm74 896 1 No no DT cord-015021-pol2qm74 896 2 differences difference NNS cord-015021-pol2qm74 896 3 were be VBD cord-015021-pol2qm74 896 4 seen see VBN cord-015021-pol2qm74 896 5 in in IN cord-015021-pol2qm74 896 6 all all DT cord-015021-pol2qm74 896 7 described describe VBN cord-015021-pol2qm74 896 8 parameters parameter NNS cord-015021-pol2qm74 896 9 for for IN cord-015021-pol2qm74 896 10 the the DT cord-015021-pol2qm74 896 11 controls control NNS cord-015021-pol2qm74 896 12 . . . cord-015021-pol2qm74 897 1 These these DT cord-015021-pol2qm74 897 2 data datum NNS cord-015021-pol2qm74 897 3 show show VBP cord-015021-pol2qm74 897 4 that that IN cord-015021-pol2qm74 897 5 the the DT cord-015021-pol2qm74 897 6 gut gut NN cord-015021-pol2qm74 897 7 barrier barrier NN cord-015021-pol2qm74 897 8 can can MD cord-015021-pol2qm74 897 9 be be VB cord-015021-pol2qm74 897 10 compromised compromise VBN cord-015021-pol2qm74 897 11 by by IN cord-015021-pol2qm74 897 12 mininml mininml JJ cord-015021-pol2qm74 897 13 invasive invasive JJ cord-015021-pol2qm74 897 14 procedures procedure NNS cord-015021-pol2qm74 897 15 , , , cord-015021-pol2qm74 897 16 at at IN cord-015021-pol2qm74 897 17 least least JJS cord-015021-pol2qm74 897 18 , , , cord-015021-pol2qm74 897 19 concerning concern VBG cord-015021-pol2qm74 897 20 bacterial bacterial JJ cord-015021-pol2qm74 897 21 products product NNS cord-015021-pol2qm74 897 22 . . . cord-015021-pol2qm74 898 1 Living live VBG cord-015021-pol2qm74 898 2 bacteria bacteria NNS cord-015021-pol2qm74 898 3 , , , cord-015021-pol2qm74 898 4 on on IN cord-015021-pol2qm74 898 5 the the DT cord-015021-pol2qm74 898 6 contrary contrary NN cord-015021-pol2qm74 898 7 , , , cord-015021-pol2qm74 898 8 do do VB cord-015021-pol2qm74 898 9 not not RB cord-015021-pol2qm74 898 10 pass pass VB cord-015021-pol2qm74 898 11 the the DT cord-015021-pol2qm74 898 12 gastro gastro JJ cord-015021-pol2qm74 898 13 - - JJ cord-015021-pol2qm74 898 14 intestinal intestinal JJ cord-015021-pol2qm74 898 15 wall wall NN cord-015021-pol2qm74 898 16 . . . cord-015021-pol2qm74 899 1 Endotoxin endotoxin NN cord-015021-pol2qm74 899 2 , , , cord-015021-pol2qm74 899 3 when when WRB cord-015021-pol2qm74 899 4 determined determine VBN cord-015021-pol2qm74 899 5 by by IN cord-015021-pol2qm74 899 6 ENC ENC NNP cord-015021-pol2qm74 899 7 , , , cord-015021-pol2qm74 899 8 is be VBZ cord-015021-pol2qm74 899 9 more more RBR cord-015021-pol2qm74 899 10 sensitive sensitive JJ cord-015021-pol2qm74 899 11 than than IN cord-015021-pol2qm74 899 12 the the DT cord-015021-pol2qm74 899 13 conventional conventional JJ cord-015021-pol2qm74 899 14 limulus limulus NN cord-015021-pol2qm74 899 15 - - HYPH cord-015021-pol2qm74 899 16 amebocyte amebocyte NN cord-015021-pol2qm74 899 17 - - HYPH cord-015021-pol2qm74 899 18 lysate lysate NN cord-015021-pol2qm74 899 19 test test NN cord-015021-pol2qm74 899 20 . . . cord-015021-pol2qm74 900 1 No no DT cord-015021-pol2qm74 900 2 acute acute JJ cord-015021-pol2qm74 900 3 - - HYPH cord-015021-pol2qm74 900 4 phase phase NN cord-015021-pol2qm74 900 5 reaction reaction NN cord-015021-pol2qm74 900 6 was be VBD cord-015021-pol2qm74 900 7 induceri induceri JJ cord-015021-pol2qm74 900 8 by by IN cord-015021-pol2qm74 900 9 the the DT cord-015021-pol2qm74 900 10 observed observed JJ cord-015021-pol2qm74 900 11 endotoxin endotoxin NN cord-015021-pol2qm74 900 12 translocation translocation NN cord-015021-pol2qm74 900 13 . . . cord-015021-pol2qm74 901 1 It -PRON- PRP cord-015021-pol2qm74 901 2 can can MD cord-015021-pol2qm74 901 3 be be VB cord-015021-pol2qm74 901 4 speculated speculate VBN cord-015021-pol2qm74 901 5 from from IN cord-015021-pol2qm74 901 6 the the DT cord-015021-pol2qm74 901 7 dramatically dramatically RB cord-015021-pol2qm74 901 8 enhanced enhance VBN cord-015021-pol2qm74 901 9 thromboxane thromboxane NN cord-015021-pol2qm74 901 10 B b NN cord-015021-pol2qm74 901 11 2 2 CD cord-015021-pol2qm74 901 12 levels level NNS cord-015021-pol2qm74 901 13 , , , cord-015021-pol2qm74 901 14 together together RB cord-015021-pol2qm74 901 15 with with IN cord-015021-pol2qm74 901 16 its -PRON- PRP$ cord-015021-pol2qm74 901 17 hemodynamie hemodynamie NN cord-015021-pol2qm74 901 18 effects effect NNS cord-015021-pol2qm74 901 19 , , , cord-015021-pol2qm74 901 20 that that IN cord-015021-pol2qm74 901 21 the the DT cord-015021-pol2qm74 901 22 thromboxane thromboxane NN cord-015021-pol2qm74 901 23 release release NN cord-015021-pol2qm74 901 24 may may MD cord-015021-pol2qm74 901 25 support support VB cord-015021-pol2qm74 901 26 translocation translocation NN cord-015021-pol2qm74 901 27 of of IN cord-015021-pol2qm74 901 28 bacterial bacterial JJ cord-015021-pol2qm74 901 29 products product NNS cord-015021-pol2qm74 901 30 . . . cord-015021-pol2qm74 902 1 Sepsis sepsis NN cord-015021-pol2qm74 902 2 is be VBZ cord-015021-pol2qm74 902 3 common common JJ cord-015021-pol2qm74 902 4 after after IN cord-015021-pol2qm74 902 5 hemorrhagic hemorrhagic JJ cord-015021-pol2qm74 902 6 shock shock NN cord-015021-pol2qm74 902 7 . . . cord-015021-pol2qm74 903 1 This this DT cord-015021-pol2qm74 903 2 study study NN cord-015021-pol2qm74 903 3 aims aim VBZ cord-015021-pol2qm74 903 4 to to TO cord-015021-pol2qm74 903 5 demonstrate demonstrate VB cord-015021-pol2qm74 903 6 that that IN cord-015021-pol2qm74 903 7 hemorrhagic hemorrhagic JJ cord-015021-pol2qm74 903 8 shock shock NN cord-015021-pol2qm74 903 9 alone alone RB cord-015021-pol2qm74 903 10 can can MD cord-015021-pol2qm74 903 11 promote promote VB cord-015021-pol2qm74 903 12 translocation translocation NN cord-015021-pol2qm74 903 13 of of IN cord-015021-pol2qm74 903 14 gut gut NN cord-015021-pol2qm74 903 15 bacteria bacteria NNS cord-015021-pol2qm74 903 16 from from IN cord-015021-pol2qm74 903 17 intestinal intestinal JJ cord-015021-pol2qm74 903 18 tract tract NN cord-015021-pol2qm74 903 19 to to IN cord-015021-pol2qm74 903 20 its -PRON- PRP$ cord-015021-pol2qm74 903 21 regional regional JJ cord-015021-pol2qm74 903 22 nodes node NNS cord-015021-pol2qm74 903 23 and and CC cord-015021-pol2qm74 903 24 subsequently subsequently RB cord-015021-pol2qm74 903 25 to to IN cord-015021-pol2qm74 903 26 blood blood NN cord-015021-pol2qm74 903 27 . . . cord-015021-pol2qm74 904 1 One one CD cord-015021-pol2qm74 904 2 hundred hundred CD cord-015021-pol2qm74 904 3 twenty twenty CD cord-015021-pol2qm74 904 4 mice mouse NNS cord-015021-pol2qm74 904 5 , , , cord-015021-pol2qm74 904 6 divided divide VBN cord-015021-pol2qm74 904 7 into into IN cord-015021-pol2qm74 904 8 4 4 CD cord-015021-pol2qm74 904 9 groups group NNS cord-015021-pol2qm74 904 10 were be VBD cord-015021-pol2qm74 904 11 subjected subject VBN cord-015021-pol2qm74 904 12 to to IN cord-015021-pol2qm74 904 13 30 30 CD cord-015021-pol2qm74 904 14 , , , cord-015021-pol2qm74 904 15 60 60 CD cord-015021-pol2qm74 904 16 and and CC cord-015021-pol2qm74 904 17 120 120 CD cord-015021-pol2qm74 904 18 minutes minute NNS cord-015021-pol2qm74 904 19 of of IN cord-015021-pol2qm74 904 20 20 20 CD cord-015021-pol2qm74 904 21 % % NN cord-015021-pol2qm74 904 22 , , , cord-015021-pol2qm74 904 23 30 30 CD cord-015021-pol2qm74 904 24 % % NN cord-015021-pol2qm74 904 25 and and CC cord-015021-pol2qm74 904 26 40 40 CD cord-015021-pol2qm74 904 27 % % NN cord-015021-pol2qm74 904 28 of of IN cord-015021-pol2qm74 904 29 hemorrhagic hemorrhagic JJ cord-015021-pol2qm74 904 30 shock shock NN cord-015021-pol2qm74 904 31 . . . cord-015021-pol2qm74 905 1 On on IN cord-015021-pol2qm74 905 2 the the DT cord-015021-pol2qm74 905 3 specified specify VBN cord-015021-pol2qm74 905 4 time time NN cord-015021-pol2qm74 905 5 , , , cord-015021-pol2qm74 905 6 blood blood NN cord-015021-pol2qm74 905 7 cultures culture NNS cord-015021-pol2qm74 905 8 were be VBD cord-015021-pol2qm74 905 9 taken take VBN cord-015021-pol2qm74 905 10 and and CC cord-015021-pol2qm74 905 11 mice mouse NNS cord-015021-pol2qm74 905 12 were be VBD cord-015021-pol2qm74 905 13 sacrificed sacrifice VBN cord-015021-pol2qm74 905 14 . . . cord-015021-pol2qm74 906 1 The the DT cord-015021-pol2qm74 906 2 intestinal intestinal JJ cord-015021-pol2qm74 906 3 tract tract NN cord-015021-pol2qm74 906 4 were be VBD cord-015021-pol2qm74 906 5 histologically histologically RB cord-015021-pol2qm74 906 6 examined examine VBN cord-015021-pol2qm74 906 7 for for IN cord-015021-pol2qm74 906 8 any any DT cord-015021-pol2qm74 906 9 changes change NNS cord-015021-pol2qm74 906 10 which which WDT cord-015021-pol2qm74 906 11 allows allow VBZ cord-015021-pol2qm74 906 12 translocation translocation NN cord-015021-pol2qm74 906 13 and and CC cord-015021-pol2qm74 906 14 its -PRON- PRP$ cord-015021-pol2qm74 906 15 regional regional JJ cord-015021-pol2qm74 906 16 nodes node NNS cord-015021-pol2qm74 906 17 were be VBD cord-015021-pol2qm74 906 18 quantitatively quantitatively RB cord-015021-pol2qm74 906 19 cultured culture VBN cord-015021-pol2qm74 906 20 for for IN cord-015021-pol2qm74 906 21 translocated translocate VBN cord-015021-pol2qm74 906 22 bacteria bacteria NNS cord-015021-pol2qm74 906 23 . . . cord-015021-pol2qm74 907 1 There there EX cord-015021-pol2qm74 907 2 was be VBD cord-015021-pol2qm74 907 3 a a DT cord-015021-pol2qm74 907 4 direct direct JJ cord-015021-pol2qm74 907 5 relationship relationship NN cord-015021-pol2qm74 907 6 between between IN cord-015021-pol2qm74 907 7 duration duration NN cord-015021-pol2qm74 907 8 and and CC cord-015021-pol2qm74 907 9 degree degree NN cord-015021-pol2qm74 907 10 of of IN cord-015021-pol2qm74 907 11 hemorrhagic hemorrhagic JJ cord-015021-pol2qm74 907 12 shock shock NN cord-015021-pol2qm74 907 13 and and CC cord-015021-pol2qm74 907 14 incidence incidence NN cord-015021-pol2qm74 907 15 of of IN cord-015021-pol2qm74 907 16 translocation translocation NN cord-015021-pol2qm74 907 17 ( ( -LRB- cord-015021-pol2qm74 907 18 p p NN cord-015021-pol2qm74 907 19 0.05 0.05 CD cord-015021-pol2qm74 907 20 ) ) -RRB- cord-015021-pol2qm74 907 21 . . . cord-015021-pol2qm74 908 1 There there EX cord-015021-pol2qm74 908 2 was be VBD cord-015021-pol2qm74 908 3 a a DT cord-015021-pol2qm74 908 4 high high JJ cord-015021-pol2qm74 908 5 incidence incidence NN cord-015021-pol2qm74 908 6 of of IN cord-015021-pol2qm74 908 7 gut gut NN cord-015021-pol2qm74 908 8 bacterial bacterial JJ cord-015021-pol2qm74 908 9 translocation translocation NN cord-015021-pol2qm74 908 10 to to IN cord-015021-pol2qm74 908 11 the the DT cord-015021-pol2qm74 908 12 mesenteric mesenteric JJ cord-015021-pol2qm74 908 13 and and CC cord-015021-pol2qm74 908 14 mesocolic mesocolic JJ cord-015021-pol2qm74 908 15 nodes node NNS cord-015021-pol2qm74 908 16 in in IN cord-015021-pol2qm74 908 17 all all DT cord-015021-pol2qm74 908 18 degrees degree NNS cord-015021-pol2qm74 908 19 of of IN cord-015021-pol2qm74 908 20 shock shock NN cord-015021-pol2qm74 908 21 ( ( -LRB- cord-015021-pol2qm74 908 22 p p NN cord-015021-pol2qm74 908 23 0.05 0.05 CD cord-015021-pol2qm74 908 24 ) ) -RRB- cord-015021-pol2qm74 908 25 . . . cord-015021-pol2qm74 909 1 Bacterial bacterial JJ cord-015021-pol2qm74 909 2 growth growth NN cord-015021-pol2qm74 909 3 in in IN cord-015021-pol2qm74 909 4 the the DT cord-015021-pol2qm74 909 5 regional regional JJ cord-015021-pol2qm74 909 6 intestinal intestinal JJ cord-015021-pol2qm74 909 7 nodes node NNS cord-015021-pol2qm74 909 8 increased increase VBD cord-015021-pol2qm74 909 9 and and CC cord-015021-pol2qm74 909 10 blood blood NN cord-015021-pol2qm74 909 11 cultures culture NNS cord-015021-pol2qm74 909 12 were be VBD cord-015021-pol2qm74 909 13 positive positive JJ cord-015021-pol2qm74 909 14 in in IN cord-015021-pol2qm74 909 15 direct direct JJ cord-015021-pol2qm74 909 16 proportion proportion NN cord-015021-pol2qm74 909 17 to to IN cord-015021-pol2qm74 909 18 degree degree NN cord-015021-pol2qm74 909 19 and and CC cord-015021-pol2qm74 909 20 duration duration NN cord-015021-pol2qm74 909 21 of of IN cord-015021-pol2qm74 909 22 shock shock NN cord-015021-pol2qm74 909 23 . . . cord-015021-pol2qm74 910 1 Histologic Histologic NNP cord-015021-pol2qm74 910 2 evaluation evaluation NN cord-015021-pol2qm74 910 3 of of IN cord-015021-pol2qm74 910 4 segments segment NNS cord-015021-pol2qm74 910 5 of of IN cord-015021-pol2qm74 910 6 GIT GIT NNP cord-015021-pol2qm74 910 7 showed show VBD cord-015021-pol2qm74 910 8 submucosal submucosal NNP cord-015021-pol2qm74 910 9 congestion congestion NN cord-015021-pol2qm74 910 10 to to TO cord-015021-pol2qm74 910 11 allow allow VB cord-015021-pol2qm74 910 12 bacteria bacteria NNS cord-015021-pol2qm74 910 13 normally normally RB cord-015021-pol2qm74 910 14 contained contain VBN cord-015021-pol2qm74 910 15 within within IN cord-015021-pol2qm74 910 16 the the DT cord-015021-pol2qm74 910 17 gut gut NN cord-015021-pol2qm74 910 18 to to TO cord-015021-pol2qm74 910 19 cause cause VB cord-015021-pol2qm74 910 20 systemic systemic JJ cord-015021-pol2qm74 910 21 infections infection NNS cord-015021-pol2qm74 910 22 . . . cord-015021-pol2qm74 911 1 Translocation translocation NN cord-015021-pol2qm74 911 2 of of IN cord-015021-pol2qm74 911 3 gut gut NN cord-015021-pol2qm74 911 4 bacteria bacteria NNS cord-015021-pol2qm74 911 5 in in IN cord-015021-pol2qm74 911 6 untreated untreated JJ cord-015021-pol2qm74 911 7 hemorrhagic hemorrhagic JJ cord-015021-pol2qm74 911 8 shock shock NN cord-015021-pol2qm74 911 9 is be VBZ cord-015021-pol2qm74 911 10 clearly clearly RB cord-015021-pol2qm74 911 11 shown show VBN cord-015021-pol2qm74 911 12 in in IN cord-015021-pol2qm74 911 13 this this DT cord-015021-pol2qm74 911 14 study study NN cord-015021-pol2qm74 911 15 on on IN cord-015021-pol2qm74 911 16 animal animal NN cord-015021-pol2qm74 911 17 models model NNS cord-015021-pol2qm74 911 18 . . . cord-015021-pol2qm74 912 1 In in IN cord-015021-pol2qm74 912 2 this this DT cord-015021-pol2qm74 912 3 study study NN cord-015021-pol2qm74 912 4 , , , cord-015021-pol2qm74 912 5 guotobiotic guotobiotic JJ cord-015021-pol2qm74 912 6 rats rat NNS cord-015021-pol2qm74 912 7 with with IN cord-015021-pol2qm74 912 8 5 5 CD cord-015021-pol2qm74 912 9 known know VBN cord-015021-pol2qm74 912 10 species specie NNS cord-015021-pol2qm74 912 11 of of IN cord-015021-pol2qm74 912 12 bacteria bacteria NNS cord-015021-pol2qm74 912 13 were be VBD cord-015021-pol2qm74 912 14 subjected subject VBN cord-015021-pol2qm74 912 15 to to TO cord-015021-pol2qm74 912 16 total total VB cord-015021-pol2qm74 912 17 parenteral parenteral JJ cord-015021-pol2qm74 912 18 nutrition(TPN nutrition(tpn NN cord-015021-pol2qm74 912 19 ) ) -RRB- cord-015021-pol2qm74 912 20 and and CC cord-015021-pol2qm74 912 21 subsequent subsequent JJ cord-015021-pol2qm74 912 22 hemorrhagic hemorrhagic JJ cord-015021-pol2qm74 912 23 shock shock NN cord-015021-pol2qm74 912 24 . . . cord-015021-pol2qm74 913 1 The the DT cord-015021-pol2qm74 913 2 purpose purpose NN cord-015021-pol2qm74 913 3 of of IN cord-015021-pol2qm74 913 4 the the DT cord-015021-pol2qm74 913 5 study study NN cord-015021-pol2qm74 913 6 was be VBD cord-015021-pol2qm74 913 7 to to TO cord-015021-pol2qm74 913 8 observe observe VB cord-015021-pol2qm74 913 9 the the DT cord-015021-pol2qm74 913 10 impairment impairment NN cord-015021-pol2qm74 913 11 of of IN cord-015021-pol2qm74 913 12 gut gut NN cord-015021-pol2qm74 913 13 barrier barrier NN cord-015021-pol2qm74 913 14 function function NN cord-015021-pol2qm74 913 15 following follow VBG cord-015021-pol2qm74 913 16 TPN TPN NNP cord-015021-pol2qm74 913 17 and and CC cord-015021-pol2qm74 913 18 hemorrhagic hemorrhagic JJ cord-015021-pol2qm74 913 19 shock shock NN cord-015021-pol2qm74 913 20 and and CC cord-015021-pol2qm74 913 21 to to TO cord-015021-pol2qm74 913 22 study study VB cord-015021-pol2qm74 913 23 the the DT cord-015021-pol2qm74 913 24 mechanism mechanism NN cord-015021-pol2qm74 913 25 of of IN cord-015021-pol2qm74 913 26 enterogenic enterogenic NNP cord-015021-pol2qm74 913 27 infection infection NN cord-015021-pol2qm74 913 28 induced induce VBN cord-015021-pol2qm74 913 29 by by IN cord-015021-pol2qm74 913 30 TPN TPN NNP cord-015021-pol2qm74 913 31 and and CC cord-015021-pol2qm74 913 32 shock shock NN cord-015021-pol2qm74 913 33 . . . cord-015021-pol2qm74 914 1 The the DT cord-015021-pol2qm74 914 2 results result NNS cord-015021-pol2qm74 914 3 were be VBD cord-015021-pol2qm74 914 4 as as IN cord-015021-pol2qm74 914 5 follows follow VBZ cord-015021-pol2qm74 914 6 : : : cord-015021-pol2qm74 914 7 1.Long 1.long CD cord-015021-pol2qm74 914 8 term(8 term(8 CD cord-015021-pol2qm74 914 9 - - SYM cord-015021-pol2qm74 914 10 12 12 CD cord-015021-pol2qm74 914 11 days day NNS cord-015021-pol2qm74 914 12 ) ) -RRB- cord-015021-pol2qm74 915 1 TPN TPN NNP cord-015021-pol2qm74 915 2 induced induce VBN cord-015021-pol2qm74 915 3 impairment impairment NN cord-015021-pol2qm74 915 4 of of IN cord-015021-pol2qm74 915 5 gut gut NN cord-015021-pol2qm74 915 6 barrier barrier NN cord-015021-pol2qm74 915 7 function function NN cord-015021-pol2qm74 915 8 , , , cord-015021-pol2qm74 915 9 evidenced evidence VBN cord-015021-pol2qm74 915 10 by by IN cord-015021-pol2qm74 915 11 atrophy atrophy NN cord-015021-pol2qm74 915 12 of of IN cord-015021-pol2qm74 915 13 intestinal intestinal JJ cord-015021-pol2qm74 915 14 mucosa mucosa NN cord-015021-pol2qm74 915 15 , , , cord-015021-pol2qm74 915 16 significant significant JJ cord-015021-pol2qm74 915 17 decrease decrease NN cord-015021-pol2qm74 915 18 in in IN cord-015021-pol2qm74 915 19 diamine diamine NN cord-015021-pol2qm74 915 20 oxidase oxidase NN cord-015021-pol2qm74 915 21 activity activity NN cord-015021-pol2qm74 915 22 of of IN cord-015021-pol2qm74 915 23 intestinal intestinal JJ cord-015021-pol2qm74 915 24 mucosa mucosa NN cord-015021-pol2qm74 915 25 and and CC cord-015021-pol2qm74 915 26 blood blood NN cord-015021-pol2qm74 915 27 , , , cord-015021-pol2qm74 915 28 and and CC cord-015021-pol2qm74 915 29 marked mark VBD cord-015021-pol2qm74 915 30 microecologic microecologic JJ cord-015021-pol2qm74 915 31 imbalance imbalance NN cord-015021-pol2qm74 915 32 of of IN cord-015021-pol2qm74 915 33 the the DT cord-015021-pol2qm74 915 34 intestinal intestinal JJ cord-015021-pol2qm74 915 35 mucosa mucosa NN cord-015021-pol2qm74 915 36 flora flora NNS cord-015021-pol2qm74 915 37 with with IN cord-015021-pol2qm74 915 38 dorminant dorminant JJ cord-015021-pol2qm74 915 39 growth growth NN cord-015021-pol2qm74 915 40 of of IN cord-015021-pol2qm74 915 41 aerobes aerobe NNS cord-015021-pol2qm74 915 42 and and CC cord-015021-pol2qm74 915 43 relative relative JJ cord-015021-pol2qm74 915 44 decrease decrease NN cord-015021-pol2qm74 915 45 in in IN cord-015021-pol2qm74 915 46 anaerobes anaerobe NNS cord-015021-pol2qm74 915 47 . . . cord-015021-pol2qm74 916 1 The the DT cord-015021-pol2qm74 916 2 degree degree NN cord-015021-pol2qm74 916 3 of of IN cord-015021-pol2qm74 916 4 mucosal mucosal JJ cord-015021-pol2qm74 916 5 damage damage NN cord-015021-pol2qm74 916 6 were be VBD cord-015021-pol2qm74 916 7 proportional proportional JJ cord-015021-pol2qm74 916 8 to to IN cord-015021-pol2qm74 916 9 the the DT cord-015021-pol2qm74 916 10 duration duration NN cord-015021-pol2qm74 916 11 of of IN cord-015021-pol2qm74 916 12 TPN TPN NNP cord-015021-pol2qm74 916 13 . . . cord-015021-pol2qm74 917 1 2.In 2.in CD cord-015021-pol2qm74 917 2 TPN+shock TPN+shock NNP cord-015021-pol2qm74 917 3 groups group NNS cord-015021-pol2qm74 917 4 , , , cord-015021-pol2qm74 917 5 failure failure NN cord-015021-pol2qm74 917 6 of of IN cord-015021-pol2qm74 917 7 gut gut NN cord-015021-pol2qm74 917 8 barrier barrier NN cord-015021-pol2qm74 917 9 function function NN cord-015021-pol2qm74 917 10 was be VBD cord-015021-pol2qm74 917 11 found find VBN cord-015021-pol2qm74 917 12 . . . cord-015021-pol2qm74 918 1 ri,~ere ri,~ere NNP cord-015021-pol2qm74 918 2 were be VBD cord-015021-pol2qm74 918 3 further further JJ cord-015021-pol2qm74 918 4 damage damage NN cord-015021-pol2qm74 918 5 in in IN cord-015021-pol2qm74 918 6 the the DT cord-015021-pol2qm74 918 7 mucosa mucosa NN cord-015021-pol2qm74 918 8 , , , cord-015021-pol2qm74 918 9 with with IN cord-015021-pol2qm74 918 10 a a DT cord-015021-pol2qm74 918 11 large large JJ cord-015021-pol2qm74 918 12 number number NN cord-015021-pol2qm74 918 13 of of IN cord-015021-pol2qm74 918 14 gramnegative gramnegative JJ cord-015021-pol2qm74 918 15 organisms organism NNS cord-015021-pol2qm74 918 16 invading invade VBG cord-015021-pol2qm74 918 17 mucosa mucosa JJ cord-015021-pol2qm74 918 18 and and CC cord-015021-pol2qm74 918 19 submucosa submucosa NNS cord-015021-pol2qm74 918 20 and and CC cord-015021-pol2qm74 918 21 a a DT cord-015021-pol2qm74 918 22 significant significant JJ cord-015021-pol2qm74 918 23 decrease decrease NN cord-015021-pol2qm74 918 24 in in IN cord-015021-pol2qm74 918 25 DAO DAO NNP cord-015021-pol2qm74 918 26 activity activity NN cord-015021-pol2qm74 918 27 as as IN cord-015021-pol2qm74 918 28 compared compare VBN cord-015021-pol2qm74 918 29 with with IN cord-015021-pol2qm74 918 30 each each DT cord-015021-pol2qm74 918 31 relative relative JJ cord-015021-pol2qm74 918 32 TPN TPN NNP cord-015021-pol2qm74 918 33 groups group NNS cord-015021-pol2qm74 918 34 . . . cord-015021-pol2qm74 919 1 These these DT cord-015021-pol2qm74 919 2 changes change NNS cord-015021-pol2qm74 919 3 were be VBD cord-015021-pol2qm74 919 4 significantly significantly RB cord-015021-pol2qm74 919 5 correlated correlate VBN cord-015021-pol2qm74 919 6 with with IN cord-015021-pol2qm74 919 7 enhanced enhanced JJ cord-015021-pol2qm74 919 8 bacterial bacterial JJ cord-015021-pol2qm74 919 9 translocation translocation NN cord-015021-pol2qm74 919 10 , , , cord-015021-pol2qm74 919 11 elevation elevation NN cord-015021-pol2qm74 919 12 of of IN cord-015021-pol2qm74 919 13 LPS LPS NNP cord-015021-pol2qm74 919 14 and and CC cord-015021-pol2qm74 919 15 MDA MDA NNP cord-015021-pol2qm74 919 16 levels level NNS cord-015021-pol2qm74 919 17 in in IN cord-015021-pol2qm74 919 18 the the DT cord-015021-pol2qm74 919 19 plasma plasma NN cord-015021-pol2qm74 919 20 . . . cord-015021-pol2qm74 920 1 These these DT cord-015021-pol2qm74 920 2 findings finding NNS cord-015021-pol2qm74 920 3 suggested suggest VBD cord-015021-pol2qm74 920 4 that that IN cord-015021-pol2qm74 920 5 long long JJ cord-015021-pol2qm74 920 6 term term NN cord-015021-pol2qm74 920 7 standard standard JJ cord-015021-pol2qm74 920 8 TPN TPN NNP cord-015021-pol2qm74 920 9 impaired impair VBD cord-015021-pol2qm74 920 10 the the DT cord-015021-pol2qm74 920 11 gut gut NN cord-015021-pol2qm74 920 12 barrier barrier NN cord-015021-pol2qm74 920 13 function function NN cord-015021-pol2qm74 920 14 , , , cord-015021-pol2qm74 920 15 precipitating precipitate VBG cord-015021-pol2qm74 920 16 posttraumatic posttraumatic JJ cord-015021-pol2qm74 920 17 gut gut NN cord-015021-pol2qm74 920 18 barrier barrier NN cord-015021-pol2qm74 920 19 failure failure NN cord-015021-pol2qm74 920 20 . . . cord-015021-pol2qm74 921 1 Thus thus RB cord-015021-pol2qm74 921 2 infec infec IN cord-015021-pol2qm74 921 3 . . . cord-015021-pol2qm74 922 1 fion fion NNP cord-015021-pol2qm74 922 2 following follow VBG cord-015021-pol2qm74 922 3 shock shock NN cord-015021-pol2qm74 922 4 might may MD cord-015021-pol2qm74 922 5 be be VB cord-015021-pol2qm74 922 6 oi'iginated oi'iginate VBN cord-015021-pol2qm74 922 7 from from IN cord-015021-pol2qm74 922 8 the the DT cord-015021-pol2qm74 922 9 gut gut NN cord-015021-pol2qm74 923 1 and and CC cord-015021-pol2qm74 923 2 it -PRON- PRP cord-015021-pol2qm74 923 3 was be VBD cord-015021-pol2qm74 923 4 obviously obviously RB cord-015021-pol2qm74 923 5 related relate VBN cord-015021-pol2qm74 923 6 to to IN cord-015021-pol2qm74 923 7 the the DT cord-015021-pol2qm74 923 8 impaired impair VBN cord-015021-pol2qm74 923 9 gut gut NN cord-015021-pol2qm74 923 10 defence defence NN cord-015021-pol2qm74 923 11 resulted result VBD cord-015021-pol2qm74 923 12 from from IN cord-015021-pol2qm74 923 13 antecedent antecedent JJ cord-015021-pol2qm74 923 14 TPN TPN NNP cord-015021-pol2qm74 923 15 . . . cord-015021-pol2qm74 924 1 The the DT cord-015021-pol2qm74 924 2 determination determination NN cord-015021-pol2qm74 924 3 of of IN cord-015021-pol2qm74 924 4 plasma plasma NN cord-015021-pol2qm74 924 5 DAO DAO NNP cord-015021-pol2qm74 924 6 activity activity NN cord-015021-pol2qm74 924 7 might may MD cord-015021-pol2qm74 924 8 provide provide VB cord-015021-pol2qm74 924 9 a a DT cord-015021-pol2qm74 924 10 valuable valuable JJ cord-015021-pol2qm74 924 11 tool tool NN cord-015021-pol2qm74 924 12 for for IN cord-015021-pol2qm74 924 13 the the DT cord-015021-pol2qm74 924 14 ear ear NN cord-015021-pol2qm74 924 15 . . . cord-015021-pol2qm74 925 1 ly ly IN cord-015021-pol2qm74 925 2 diagnosis diagnosis NN cord-015021-pol2qm74 925 3 of of IN cord-015021-pol2qm74 925 4 gut gut NN cord-015021-pol2qm74 926 1 injut;y injut;y NNP cord-015021-pol2qm74 926 2 during during IN cord-015021-pol2qm74 926 3 TPN TPN NNP cord-015021-pol2qm74 926 4 and and CC cord-015021-pol2qm74 926 5 after after IN cord-015021-pol2qm74 926 6 trauma trauma NN cord-015021-pol2qm74 926 7 . . . cord-015021-pol2qm74 927 1 In in IN cord-015021-pol2qm74 927 2 our -PRON- PRP$ cord-015021-pol2qm74 927 3 earlier early JJR cord-015021-pol2qm74 927 4 studies study NNS cord-015021-pol2qm74 927 5 we -PRON- PRP cord-015021-pol2qm74 927 6 have have VBP cord-015021-pol2qm74 927 7 investigated investigate VBN cord-015021-pol2qm74 927 8 the the DT cord-015021-pol2qm74 927 9 dynamics dynamic NNS cord-015021-pol2qm74 927 10 of of IN cord-015021-pol2qm74 927 11 granuloayte granuloayte JJ cord-015021-pol2qm74 927 12 infiltration infiltration NN cord-015021-pol2qm74 927 13 of of IN cord-015021-pol2qm74 927 14 the the DT cord-015021-pol2qm74 927 15 ischemic ischemic JJ cord-015021-pol2qm74 927 16 / / SYM cord-015021-pol2qm74 927 17 reperfused reperfused JJ cord-015021-pol2qm74 927 18 s s NNP cord-015021-pol2qm74 927 19 ~ ~ NFP cord-015021-pol2qm74 927 20 all all DT cord-015021-pol2qm74 927 21 intestine intestine NN cord-015021-pol2qm74 927 22 ( ( -LRB- cord-015021-pol2qm74 927 23 G. G. NNP cord-015021-pol2qm74 927 24 Illy Illy NNP cord-015021-pol2qm74 927 25 ~ ~ NNP cord-015021-pol2qm74 927 26 s s NNP cord-015021-pol2qm74 927 27 , , , cord-015021-pol2qm74 927 28 J. J. NNP cord-015021-pol2qm74 927 29 Hamar Hamar NNP cord-015021-pol2qm74 927 30 Int Int NNP cord-015021-pol2qm74 927 31 . . NNP cord-015021-pol2qm74 927 32 J. J. NNP cord-015021-pol2qm74 927 33 Exp Exp NNP cord-015021-pol2qm74 927 34 . . . cord-015021-pol2qm74 928 1 9athol 9athol CD cord-015021-pol2qm74 928 2 . . . cord-015021-pol2qm74 929 1 73 73 CD cord-015021-pol2qm74 929 2 . . . cord-015021-pol2qm74 930 1 161 161 CD cord-015021-pol2qm74 930 2 . . . cord-015021-pol2qm74 930 3 1992 1992 CD cord-015021-pol2qm74 930 4 . . . cord-015021-pol2qm74 930 5 ) ) -RRB- cord-015021-pol2qm74 930 6 . . . cord-015021-pol2qm74 931 1 There there EX cord-015021-pol2qm74 931 2 was be VBD cord-015021-pol2qm74 931 3 a a DT cord-015021-pol2qm74 931 4 increasing increase VBG cord-015021-pol2qm74 931 5 infiltration infiltration NN cord-015021-pol2qm74 931 6 of of IN cord-015021-pol2qm74 931 7 the the DT cord-015021-pol2qm74 931 8 mucosa mucosa JJ cord-015021-pol2qm74 931 9 c111m c111m CD cord-015021-pol2qm74 931 10 ~ ~ NFP cord-015021-pol2qm74 931 11 nating nate VBG cord-015021-pol2qm74 931 12 at at IN cord-015021-pol2qm74 931 13 the the DT cord-015021-pol2qm74 931 14 3d 3d NNP cord-015021-pol2qm74 931 15 to to IN cord-015021-pol2qm74 931 16 4th 4th JJ cord-015021-pol2qm74 931 17 hours hour NNS cord-015021-pol2qm74 931 18 of of IN cord-015021-pol2qm74 931 19 reperfusion reperfusion NN cord-015021-pol2qm74 931 20 . . . cord-015021-pol2qm74 932 1 In in IN cord-015021-pol2qm74 932 2 the the DT cord-015021-pol2qm74 932 3 present present JJ cord-015021-pol2qm74 932 4 series series NN cord-015021-pol2qm74 932 5 we -PRON- PRP cord-015021-pol2qm74 932 6 have have VBP cord-015021-pol2qm74 932 7 studied study VBN cord-015021-pol2qm74 932 8 sc sc NNP cord-015021-pol2qm74 932 9 ~ ~ NNP cord-015021-pol2qm74 932 10 e e NNP cord-015021-pol2qm74 932 11 of of IN cord-015021-pol2qm74 932 12 the the DT cord-015021-pol2qm74 932 13 conseqn conseqn NNP cord-015021-pol2qm74 932 14 / / SYM cord-015021-pol2qm74 932 15 ences ence NNS cord-015021-pol2qm74 932 16 and and CC cord-015021-pol2qm74 932 17 the the DT cord-015021-pol2qm74 932 18 possible possible JJ cord-015021-pol2qm74 932 19 role role NN cord-015021-pol2qm74 932 20 of of IN cord-015021-pol2qm74 932 21 this this DT cord-015021-pol2qm74 932 22 cellular cellular JJ cord-015021-pol2qm74 932 23 reaction reaction NN cord-015021-pol2qm74 932 24 . . . cord-015021-pol2qm74 933 1 45 45 CD cord-015021-pol2qm74 934 1 ~in ~in NNP cord-015021-pol2qm74 934 2 isehemia isehemia NNP cord-015021-pol2qm74 934 3 was be VBD cord-015021-pol2qm74 934 4 followed follow VBN cord-015021-pol2qm74 934 5 by by IN cord-015021-pol2qm74 934 6 a a DT cord-015021-pol2qm74 934 7 4 4 CD cord-015021-pol2qm74 934 8 hour hour NN cord-015021-pol2qm74 934 9 reperfusion reperfusion NN cord-015021-pol2qm74 934 10 in in IN cord-015021-pol2qm74 934 11 the the DT cord-015021-pol2qm74 934 12 anesthetized anesthetize VBN cord-015021-pol2qm74 934 13 rat rat NN cord-015021-pol2qm74 934 14 . . . cord-015021-pol2qm74 935 1 Arterial arterial JJ cord-015021-pol2qm74 935 2 ~/ad ~/ad CD cord-015021-pol2qm74 935 3 mesenteric mesenteric JJ cord-015021-pol2qm74 935 4 venous venous JJ cord-015021-pol2qm74 935 5 blood blood NN cord-015021-pol2qm74 935 6 samples sample NNS cord-015021-pol2qm74 935 7 were be VBD cord-015021-pol2qm74 935 8 collected collect VBN cord-015021-pol2qm74 935 9 at at IN cord-015021-pol2qm74 935 10 5 5 CD cord-015021-pol2qm74 935 11 m_in m_in NN cord-015021-pol2qm74 935 12 , , , cord-015021-pol2qm74 935 13 I -PRON- PRP cord-015021-pol2qm74 935 14 , , , cord-015021-pol2qm74 935 15 2~ 2~ CD cord-015021-pol2qm74 935 16 3 3 CD cord-015021-pol2qm74 935 17 , , , cord-015021-pol2qm74 935 18 and and CC cord-015021-pol2qm74 935 19 4 4 CD cord-015021-pol2qm74 935 20 hours hour NNS cord-015021-pol2qm74 935 21 of of IN cord-015021-pol2qm74 935 22 reperfusion reperfusion NN cord-015021-pol2qm74 935 23 . . . cord-015021-pol2qm74 936 1 Elastase Elastase NNP cord-015021-pol2qm74 936 2 and and CC cord-015021-pol2qm74 936 3 lactate lactate NN cord-015021-pol2qm74 936 4 concentrations concentration NNS cord-015021-pol2qm74 936 5 were be VBD cord-015021-pol2qm74 936 6 determined determined JJ cord-015021-pol2qm74 936 7 and and CC cord-015021-pol2qm74 936 8 hamoculture hamoculture NN cord-015021-pol2qm74 936 9 was be VBD cord-015021-pol2qm74 936 10 carried carry VBN cord-015021-pol2qm74 936 11 out out RP cord-015021-pol2qm74 936 12 from from IN cord-015021-pol2qm74 936 13 the the DT cord-015021-pol2qm74 936 14 blood blood NN cord-015021-pol2qm74 936 15 samples sample NNS cord-015021-pol2qm74 936 16 , , , cord-015021-pol2qm74 936 17 and and CC cord-015021-pol2qm74 936 18 tissue tissue NN cord-015021-pol2qm74 936 19 pieces piece NNS cord-015021-pol2qm74 936 20 from from IN cord-015021-pol2qm74 936 21 the the DT cord-015021-pol2qm74 936 22 heart heart NN cord-015021-pol2qm74 936 23 , , , cord-015021-pol2qm74 936 24 lung lung NN cord-015021-pol2qm74 936 25 , , , cord-015021-pol2qm74 936 26 liver liver NN cord-015021-pol2qm74 936 27 and and CC cord-015021-pol2qm74 936 28 kidney kidney NN cord-015021-pol2qm74 936 29 were be VBD cord-015021-pol2qm74 936 30 collected collect VBN cord-015021-pol2qm74 936 31 for for IN cord-015021-pol2qm74 936 32 histological histological JJ cord-015021-pol2qm74 936 33 analyses analysis NNS cord-015021-pol2qm74 936 34 at at IN cord-015021-pol2qm74 936 35 the the DT cord-015021-pol2qm74 936 36 above above RB cord-015021-pol2qm74 936 37 mentioned mention VBN cord-015021-pol2qm74 936 38 times time NNS cord-015021-pol2qm74 936 39 of of IN cord-015021-pol2qm74 936 40 reperfusion reperfusion NN cord-015021-pol2qm74 936 41 . . . cord-015021-pol2qm74 937 1 All all DT cord-015021-pol2qm74 937 2 blood blood NN cord-015021-pol2qm74 937 3 samples sample NNS cord-015021-pol2qm74 937 4 were be VBD cord-015021-pol2qm74 937 5 free free JJ cord-015021-pol2qm74 937 6 of of IN cord-015021-pol2qm74 937 7 Cell cell NN cord-015021-pol2qm74 937 8 bacteria bacteria NNS cord-015021-pol2qm74 937 9 . . . cord-015021-pol2qm74 938 1 Staphylococci staphylococcus NNS cord-015021-pol2qm74 938 2 appeared appear VBD cord-015021-pol2qm74 938 3 only only RB cord-015021-pol2qm74 938 4 occasionally occasionally RB cord-015021-pol2qm74 938 5 at at IN cord-015021-pol2qm74 938 6 the the DT cord-015021-pol2qm74 938 7 4th 4th JJ cord-015021-pol2qm74 938 8 hour hour NN cord-015021-pol2qm74 938 9 in in IN cord-015021-pol2qm74 938 10 the the DT cord-015021-pol2qm74 938 11 arterial arterial JJ cord-015021-pol2qm74 938 12 blood blood NN cord-015021-pol2qm74 938 13 .and .and . cord-015021-pol2qm74 939 1 at at IN cord-015021-pol2qm74 939 2 the the DT cord-015021-pol2qm74 939 3 3d 3d JJ cord-015021-pol2qm74 939 4 and and CC cord-015021-pol2qm74 939 5 4th 4th JJ cord-015021-pol2qm74 939 6 hours hour NNS cord-015021-pol2qm74 939 7 in in IN cord-015021-pol2qm74 939 8 the the DT cord-015021-pol2qm74 939 9 venous venous JJ cord-015021-pol2qm74 939 10 blood blood NN cord-015021-pol2qm74 939 11 , , , cord-015021-pol2qm74 939 12 respectively respectively RB cord-015021-pol2qm74 939 13 . . . cord-015021-pol2qm74 940 1 Arterial arterial JJ cord-015021-pol2qm74 940 2 and and CC cord-015021-pol2qm74 940 3 venous venous JJ cord-015021-pol2qm74 940 4 elastase elastase NN cord-015021-pol2qm74 940 5 activities activity NNS cord-015021-pol2qm74 940 6 were be VBD cord-015021-pol2qm74 940 7 high high JJ cord-015021-pol2qm74 940 8 throughout throughout IN cord-015021-pol2qm74 940 9 the the DT cord-015021-pol2qm74 940 10 reperfusion reperfusion NN cord-015021-pol2qm74 940 11 , , , cord-015021-pol2qm74 940 12 venous venous JJ cord-015021-pol2qm74 940 13 concentrations concentration NNS cord-015021-pol2qm74 940 14 being be VBG cord-015021-pol2qm74 940 15 higher high JJR cord-015021-pol2qm74 940 16 at at IN cord-015021-pol2qm74 940 17 all all DT cord-015021-pol2qm74 940 18 times time NNS cord-015021-pol2qm74 940 19 . . . cord-015021-pol2qm74 941 1 Lactate lactate NN cord-015021-pol2qm74 941 2 concentrations concentration NNS cord-015021-pol2qm74 941 3 of of IN cord-015021-pol2qm74 941 4 the the DT cord-015021-pol2qm74 941 5 arterial arterial JJ cord-015021-pol2qm74 941 6 and and CC cord-015021-pol2qm74 941 7 mesenteric mesenteric JJ cord-015021-pol2qm74 941 8 venous venous JJ cord-015021-pol2qm74 941 9 blood blood NN cord-015021-pol2qm74 941 10 samples sample NNS cord-015021-pol2qm74 941 11 increased increase VBD cord-015021-pol2qm74 941 12 during during IN cord-015021-pol2qm74 941 13 shock shock NN cord-015021-pol2qm74 941 14 . . . cord-015021-pol2qm74 942 1 ~ranuloeyte ~ranuloeyte XX cord-015021-pol2qm74 943 1 infiltration infiltration NN cord-015021-pol2qm74 943 2 of of IN cord-015021-pol2qm74 943 3 all all DT cord-015021-pol2qm74 943 4 organs organ NNS cord-015021-pol2qm74 943 5 studied study VBN cord-015021-pol2qm74 943 6 appeared appear VBD cord-015021-pol2qm74 943 7 during during IN cord-015021-pol2qm74 943 8 the the DT cord-015021-pol2qm74 943 9 2d 2d NNP cord-015021-pol2qm74 943 10 hour hour NN cord-015021-pol2qm74 943 11 and and CC cord-015021-pol2qm74 943 12 it -PRON- PRP cord-015021-pol2qm74 943 13 increased increase VBD cord-015021-pol2qm74 943 14 at at IN cord-015021-pol2qm74 943 15 later later JJ cord-015021-pol2qm74 943 16 times time NNS cord-015021-pol2qm74 943 17 of of IN cord-015021-pol2qm74 943 18 reperfusion reperfusion NN cord-015021-pol2qm74 943 19 . . . cord-015021-pol2qm74 944 1 It -PRON- PRP cord-015021-pol2qm74 944 2 is be VBZ cord-015021-pol2qm74 944 3 concluded conclude VBN cord-015021-pol2qm74 944 4 that that IN cord-015021-pol2qm74 944 5 heavy heavy JJ cord-015021-pol2qm74 944 6 infiltration infiltration NN cord-015021-pol2qm74 944 7 of of IN cord-015021-pol2qm74 944 8 the the DT cord-015021-pol2qm74 944 9 intestinal intestinal JJ cord-015021-pol2qm74 944 10 mucosa mucosa NN cord-015021-pol2qm74 944 11 can can MD cord-015021-pol2qm74 944 12 block block VB cord-015021-pol2qm74 944 13 bacterial bacterial JJ cord-015021-pol2qm74 944 14 translocation translocation NN cord-015021-pol2qm74 944 15 in in IN cord-015021-pol2qm74 944 16 most most JJS cord-015021-pol2qm74 944 17 of of IN cord-015021-pol2qm74 944 18 the the DT cord-015021-pol2qm74 944 19 cases case NNS cord-015021-pol2qm74 944 20 during during IN cord-015021-pol2qm74 944 21 reperfusion reperfusion NN cord-015021-pol2qm74 944 22 . . . cord-015021-pol2qm74 945 1 Granulocytes granulocyte NNS cord-015021-pol2qm74 945 2 activated activate VBN cord-015021-pol2qm74 945 3 either either CC cord-015021-pol2qm74 945 4 by by IN cord-015021-pol2qm74 945 5 the the DT cord-015021-pol2qm74 945 6 reperfused reperfused JJ cord-015021-pol2qm74 945 7 area area NN cord-015021-pol2qm74 945 8 or or CC cord-015021-pol2qm74 945 9 by by IN cord-015021-pol2qm74 945 10 the the DT cord-015021-pol2qm74 945 11 released release VBN cord-015021-pol2qm74 945 12 cytokines cytokine NNS cord-015021-pol2qm74 945 13 infiltrate infiltrate VBP cord-015021-pol2qm74 945 14 other other JJ cord-015021-pol2qm74 945 15 organs organ NNS cord-015021-pol2qm74 945 16 contributing contribute VBG cord-015021-pol2qm74 945 17 by by IN cord-015021-pol2qm74 945 18 this this DT cord-015021-pol2qm74 945 19 way way NN cord-015021-pol2qm74 945 20 to to IN cord-015021-pol2qm74 945 21 the the DT cord-015021-pol2qm74 945 22 mesenteric mesenteric JJ cord-015021-pol2qm74 945 23 shock shock NN cord-015021-pol2qm74 945 24 s!rndrc s!rndrc NNP cord-015021-pol2qm74 946 1 ~e ~e NNP cord-015021-pol2qm74 946 2 . . . cord-015021-pol2qm74 947 1 Intestinal intestinal JJ cord-015021-pol2qm74 947 2 motility motility NN cord-015021-pol2qm74 947 3 plays play VBZ cord-015021-pol2qm74 947 4 an an DT cord-015021-pol2qm74 947 5 important important JJ cord-015021-pol2qm74 947 6 role role NN cord-015021-pol2qm74 947 7 for for IN cord-015021-pol2qm74 947 8 maintaining maintain VBG cord-015021-pol2qm74 947 9 nutrient nutrient NN cord-015021-pol2qm74 947 10 transport transport NN cord-015021-pol2qm74 947 11 and and CC cord-015021-pol2qm74 947 12 absorption absorption NN cord-015021-pol2qm74 947 13 and and CC cord-015021-pol2qm74 947 14 for for IN cord-015021-pol2qm74 947 15 balancing balance VBG cord-015021-pol2qm74 947 16 the the DT cord-015021-pol2qm74 947 17 enteric enteric JJ cord-015021-pol2qm74 947 18 bacterial bacterial JJ cord-015021-pol2qm74 947 19 population population NN cord-015021-pol2qm74 947 20 . . . cord-015021-pol2qm74 948 1 Disturbances disturbance NNS cord-015021-pol2qm74 948 2 of of IN cord-015021-pol2qm74 948 3 intestinal intestinal JJ cord-015021-pol2qm74 948 4 motility motility NN cord-015021-pol2qm74 948 5 may may MD cord-015021-pol2qm74 948 6 be be VB cord-015021-pol2qm74 948 7 one one CD cord-015021-pol2qm74 948 8 of of IN cord-015021-pol2qm74 948 9 the the DT cord-015021-pol2qm74 948 10 earliest early JJS cord-015021-pol2qm74 948 11 notable notable JJ cord-015021-pol2qm74 948 12 changes change NNS cord-015021-pol2qm74 948 13 in in IN cord-015021-pol2qm74 948 14 intestinal intestinal JJ cord-015021-pol2qm74 948 15 function function NN cord-015021-pol2qm74 948 16 . . . cord-015021-pol2qm74 949 1 In in IN cord-015021-pol2qm74 949 2 the the DT cord-015021-pol2qm74 949 3 present present JJ cord-015021-pol2qm74 949 4 study study NN cord-015021-pol2qm74 949 5 , , , cord-015021-pol2qm74 949 6 we -PRON- PRP cord-015021-pol2qm74 949 7 aimed aim VBD cord-015021-pol2qm74 949 8 at at IN cord-015021-pol2qm74 949 9 determining determine VBG cord-015021-pol2qm74 949 10 early early JJ cord-015021-pol2qm74 949 11 alterations alteration NNS cord-015021-pol2qm74 949 12 in in IN cord-015021-pol2qm74 949 13 intestinal intestinal JJ cord-015021-pol2qm74 949 14 transit transit NN cord-015021-pol2qm74 949 15 time time NN cord-015021-pol2qm74 949 16 following follow VBG cord-015021-pol2qm74 949 17 ischemia ischemia NN cord-015021-pol2qm74 949 18 - - HYPH cord-015021-pol2qm74 949 19 reperfusion reperfusion NN cord-015021-pol2qm74 949 20 injury injury NN cord-015021-pol2qm74 949 21 induced induce VBN cord-015021-pol2qm74 949 22 by by IN cord-015021-pol2qm74 949 23 occlusion occlusion NN cord-015021-pol2qm74 949 24 of of IN cord-015021-pol2qm74 949 25 the the DT cord-015021-pol2qm74 949 26 superior superior JJ cord-015021-pol2qm74 949 27 mesenteric mesenteric JJ cord-015021-pol2qm74 949 28 artery artery NN cord-015021-pol2qm74 949 29 in in IN cord-015021-pol2qm74 949 30 the the DT cord-015021-pol2qm74 949 31 rat rat NN cord-015021-pol2qm74 949 32 . . . cord-015021-pol2qm74 950 1 Intestinal intestinal JJ cord-015021-pol2qm74 950 2 ischemia ischemia NN cord-015021-pol2qm74 950 3 was be VBD cord-015021-pol2qm74 950 4 induced induce VBN cord-015021-pol2qm74 950 5 for for IN cord-015021-pol2qm74 950 6 20 20 CD cord-015021-pol2qm74 950 7 and and CC cord-015021-pol2qm74 950 8 30 30 CD cord-015021-pol2qm74 950 9 minutes minute NNS cord-015021-pol2qm74 950 10 by by IN cord-015021-pol2qm74 950 11 applying apply VBG cord-015021-pol2qm74 950 12 a a DT cord-015021-pol2qm74 950 13 microvascular microvascular JJ cord-015021-pol2qm74 950 14 clip clip NN cord-015021-pol2qm74 950 15 on on IN cord-015021-pol2qm74 950 16 the the DT cord-015021-pol2qm74 950 17 superior superior JJ cord-015021-pol2qm74 950 18 mesenteric mesenteric JJ cord-015021-pol2qm74 950 19 artery artery NN cord-015021-pol2qm74 950 20 followed follow VBN cord-015021-pol2qm74 950 21 by by IN cord-015021-pol2qm74 950 22 reperfusion reperfusion NN cord-015021-pol2qm74 950 23 2 2 CD cord-015021-pol2qm74 950 24 , , , cord-015021-pol2qm74 950 25 4 4 CD cord-015021-pol2qm74 950 26 and and CC cord-015021-pol2qm74 950 27 6 6 CD cord-015021-pol2qm74 950 28 hours hour NNS cord-015021-pol2qm74 950 29 after after IN cord-015021-pol2qm74 950 30 clip clip NN cord-015021-pol2qm74 950 31 removal removal NN cord-015021-pol2qm74 950 32 . . . cord-015021-pol2qm74 951 1 Intestinal intestinal JJ cord-015021-pol2qm74 951 2 transit transit NN cord-015021-pol2qm74 951 3 time time NN cord-015021-pol2qm74 951 4 was be VBD cord-015021-pol2qm74 951 5 measured measure VBN cord-015021-pol2qm74 951 6 by by IN cord-015021-pol2qm74 951 7 the the DT cord-015021-pol2qm74 951 8 propulsion propulsion NN cord-015021-pol2qm74 951 9 of of IN cord-015021-pol2qm74 951 10 a a DT cord-015021-pol2qm74 951 11 radiolabelled radiolabelled JJ cord-015021-pol2qm74 951 12 solution solution NN cord-015021-pol2qm74 951 13 ( ( -LRB- cord-015021-pol2qm74 951 14 Cr51 Cr51 NNP cord-015021-pol2qm74 951 15 ) ) -RRB- cord-015021-pol2qm74 951 16 . . . cord-015021-pol2qm74 952 1 Light light JJ cord-015021-pol2qm74 952 2 microscopy microscopy NN cord-015021-pol2qm74 952 3 was be VBD cord-015021-pol2qm74 952 4 performed perform VBN cord-015021-pol2qm74 952 5 on on IN cord-015021-pol2qm74 952 6 intestinal intestinal JJ cord-015021-pol2qm74 952 7 samples sample NNS cord-015021-pol2qm74 952 8 . . . cord-015021-pol2qm74 953 1 Macroscopical macroscopical JJ cord-015021-pol2qm74 953 2 pathological pathological JJ cord-015021-pol2qm74 953 3 changes change NNS cord-015021-pol2qm74 953 4 were be VBD cord-015021-pol2qm74 953 5 not not RB cord-015021-pol2qm74 953 6 observed observe VBN cord-015021-pol2qm74 953 7 . . . cord-015021-pol2qm74 954 1 However however RB cord-015021-pol2qm74 954 2 , , , cord-015021-pol2qm74 954 3 microscopically microscopically RB cord-015021-pol2qm74 954 4 , , , cord-015021-pol2qm74 954 5 mucosal mucosal JJ cord-015021-pol2qm74 954 6 epithelial epithelial JJ cord-015021-pol2qm74 954 7 oedema oedema NN cord-015021-pol2qm74 954 8 , , , cord-015021-pol2qm74 954 9 degeneration degeneration NN cord-015021-pol2qm74 954 10 or or CC cord-015021-pol2qm74 954 11 slight slight JJ cord-015021-pol2qm74 954 12 ulceration ulceration NN cord-015021-pol2qm74 954 13 occurred occur VBD cord-015021-pol2qm74 954 14 in in IN cord-015021-pol2qm74 954 15 rats rat NNS cord-015021-pol2qm74 954 16 6 6 CD cord-015021-pol2qm74 954 17 hours hour NNS cord-015021-pol2qm74 954 18 after after IN cord-015021-pol2qm74 954 19 reperfusion reperfusion NN cord-015021-pol2qm74 954 20 in in IN cord-015021-pol2qm74 954 21 ischemia-20 ischemia-20 CD cord-015021-pol2qm74 954 22 rain rain NN cord-015021-pol2qm74 954 23 group group NN cord-015021-pol2qm74 954 24 and and CC cord-015021-pol2qm74 954 25 4 4 CD cord-015021-pol2qm74 954 26 and and CC cord-015021-pol2qm74 954 27 6 6 CD cord-015021-pol2qm74 954 28 hours hour NNS cord-015021-pol2qm74 954 29 after after IN cord-015021-pol2qm74 954 30 reperfusion reperfusion NN cord-015021-pol2qm74 954 31 in in IN cord-015021-pol2qm74 954 32 the the DT cord-015021-pol2qm74 954 33 ischemia-40 ischemia-40 NNP cord-015021-pol2qm74 954 34 rain rain NN cord-015021-pol2qm74 954 35 group group NN cord-015021-pol2qm74 954 36 . . . cord-015021-pol2qm74 955 1 Delayed delay VBN cord-015021-pol2qm74 955 2 small small JJ cord-015021-pol2qm74 955 3 intestinal intestinal JJ cord-015021-pol2qm74 955 4 transit transit NN cord-015021-pol2qm74 955 5 time time NN cord-015021-pol2qm74 955 6 was be VBD cord-015021-pol2qm74 955 7 seen see VBN cord-015021-pol2qm74 955 8 from from IN cord-015021-pol2qm74 955 9 2 2 CD cord-015021-pol2qm74 955 10 hours hour NNS cord-015021-pol2qm74 955 11 and and CC cord-015021-pol2qm74 955 12 on on IN cord-015021-pol2qm74 955 13 after after IN cord-015021-pol2qm74 955 14 intestinal intestinal JJ cord-015021-pol2qm74 955 15 ischemia ischemia NN cord-015021-pol2qm74 955 16 for for IN cord-015021-pol2qm74 955 17 both both DT cord-015021-pol2qm74 955 18 20 20 CD cord-015021-pol2qm74 955 19 and and CC cord-015021-pol2qm74 955 20 40 40 CD cord-015021-pol2qm74 955 21 rain rain NN cord-015021-pol2qm74 955 22 ischemia ischemia NN cord-015021-pol2qm74 955 23 followed follow VBN cord-015021-pol2qm74 955 24 by by IN cord-015021-pol2qm74 955 25 reperfusion reperfusion NN cord-015021-pol2qm74 955 26 . . . cord-015021-pol2qm74 956 1 The the DT cord-015021-pol2qm74 956 2 distribution distribution NN cord-015021-pol2qm74 956 3 of of IN cord-015021-pol2qm74 956 4 radioactivity radioactivity NN cord-015021-pol2qm74 956 5 demonstrated demonstrate VBD cord-015021-pol2qm74 956 6 that that IN cord-015021-pol2qm74 956 7 most most JJS cord-015021-pol2qm74 956 8 radioactivity radioactivity NN cord-015021-pol2qm74 956 9 was be VBD cord-015021-pol2qm74 956 10 accumulated accumulate VBN cord-015021-pol2qm74 956 11 in in IN cord-015021-pol2qm74 956 12 the the DT cord-015021-pol2qm74 956 13 first first JJ cord-015021-pol2qm74 956 14 two two CD cord-015021-pol2qm74 956 15 segments segment NNS cord-015021-pol2qm74 956 16 following follow VBG cord-015021-pol2qm74 956 17 intestinal intestinal JJ cord-015021-pol2qm74 956 18 ischemia ischemia NN cord-015021-pol2qm74 956 19 and and CC cord-015021-pol2qm74 956 20 reperfusion reperfusion NN cord-015021-pol2qm74 956 21 , , , cord-015021-pol2qm74 956 22 significantly significantly RB cord-015021-pol2qm74 956 23 differing differ VBG cord-015021-pol2qm74 956 24 from from IN cord-015021-pol2qm74 956 25 what what WP cord-015021-pol2qm74 956 26 was be VBD cord-015021-pol2qm74 956 27 seen see VBN cord-015021-pol2qm74 956 28 in in IN cord-015021-pol2qm74 956 29 animals animal NNS cord-015021-pol2qm74 956 30 subjected subject VBN cord-015021-pol2qm74 956 31 to to IN cord-015021-pol2qm74 956 32 sham sham NN cord-015021-pol2qm74 956 33 operation operation NN cord-015021-pol2qm74 957 1 ( ( -LRB- cord-015021-pol2qm74 957 2 p p NN cord-015021-pol2qm74 957 3 < < XX cord-015021-pol2qm74 957 4 0.01 0.01 CD cord-015021-pol2qm74 957 5 ) ) -RRB- cord-015021-pol2qm74 957 6 . . . cord-015021-pol2qm74 958 1 The the DT cord-015021-pol2qm74 958 2 distribution distribution NN cord-015021-pol2qm74 958 3 of of IN cord-015021-pol2qm74 958 4 radioactivity radioactivity NN cord-015021-pol2qm74 958 5 in in IN cord-015021-pol2qm74 958 6 segments segment NNS cord-015021-pol2qm74 958 7 4 4 CD cord-015021-pol2qm74 958 8 and and CC cord-015021-pol2qm74 958 9 5 5 CD cord-015021-pol2qm74 958 10 in in IN cord-015021-pol2qm74 958 11 the the DT cord-015021-pol2qm74 958 12 group group NN cord-015021-pol2qm74 958 13 with with IN cord-015021-pol2qm74 958 14 repeffusion repeffusion NN cord-015021-pol2qm74 958 15 6 6 CD cord-015021-pol2qm74 958 16 hours hour NNS cord-015021-pol2qm74 958 17 after after IN cord-015021-pol2qm74 958 18 intestinal intestinal JJ cord-015021-pol2qm74 958 19 iscbemia iscbemia NN cord-015021-pol2qm74 958 20 for for IN cord-015021-pol2qm74 958 21 20 20 CD cord-015021-pol2qm74 958 22 rain rain NN cord-015021-pol2qm74 958 23 was be VBD cord-015021-pol2qm74 958 24 significantly significantly RB cord-015021-pol2qm74 958 25 higher high JJR cord-015021-pol2qm74 958 26 than than IN cord-015021-pol2qm74 958 27 that that DT cord-015021-pol2qm74 958 28 noted note VBD cord-015021-pol2qm74 958 29 in in IN cord-015021-pol2qm74 958 30 the the DT cord-015021-pol2qm74 958 31 group group NN cord-015021-pol2qm74 958 32 with with IN cord-015021-pol2qm74 958 33 repeffusion repeffusion NN cord-015021-pol2qm74 958 34 6 6 CD cord-015021-pol2qm74 958 35 hours hour NNS cord-015021-pol2qm74 958 36 after after IN cord-015021-pol2qm74 958 37 intestinal intestinal JJ cord-015021-pol2qm74 958 38 ischemia ischemia NN cord-015021-pol2qm74 958 39 for for IN cord-015021-pol2qm74 958 40 40 40 CD cord-015021-pol2qm74 958 41 min min NN cord-015021-pol2qm74 958 42 ( ( -LRB- cord-015021-pol2qm74 958 43 p p NN cord-015021-pol2qm74 958 44 < < XX cord-015021-pol2qm74 958 45 0.01 0.01 CD cord-015021-pol2qm74 958 46 ) ) -RRB- cord-015021-pol2qm74 958 47 . . . cord-015021-pol2qm74 959 1 q'he q'he NN cord-015021-pol2qm74 959 2 results result NNS cord-015021-pol2qm74 959 3 indicate indicate VBP cord-015021-pol2qm74 959 4 that that IN cord-015021-pol2qm74 959 5 a a DT cord-015021-pol2qm74 959 6 delayed delay VBN cord-015021-pol2qm74 959 7 intestinal intestinal JJ cord-015021-pol2qm74 959 8 transit transit NN cord-015021-pol2qm74 959 9 time time NN cord-015021-pol2qm74 959 10 may may MD cord-015021-pol2qm74 959 11 be be VB cord-015021-pol2qm74 959 12 one one CD cord-015021-pol2qm74 959 13 of of IN cord-015021-pol2qm74 959 14 the the DT cord-015021-pol2qm74 959 15 earliest early JJS cord-015021-pol2qm74 959 16 pathophysiological pathophysiological JJ cord-015021-pol2qm74 959 17 alterations alteration NNS cord-015021-pol2qm74 959 18 noted note VBN cord-015021-pol2qm74 959 19 , , , cord-015021-pol2qm74 959 20 associated associate VBN cord-015021-pol2qm74 959 21 with with IN cord-015021-pol2qm74 959 22 duration duration NN cord-015021-pol2qm74 959 23 of of IN cord-015021-pol2qm74 959 24 gut gut NN cord-015021-pol2qm74 959 25 ischemia ischemia NN cord-015021-pol2qm74 959 26 , , , cord-015021-pol2qm74 959 27 and and CC cord-015021-pol2qm74 959 28 a a DT cord-015021-pol2qm74 959 29 potential potential JJ cord-015021-pol2qm74 959 30 factor factor NN cord-015021-pol2qm74 959 31 for for IN cord-015021-pol2qm74 959 32 the the DT cord-015021-pol2qm74 959 33 development development NN cord-015021-pol2qm74 959 34 of of IN cord-015021-pol2qm74 959 35 bacterial bacterial JJ cord-015021-pol2qm74 959 36 overgrowth overgrowth NN cord-015021-pol2qm74 959 37 , , , cord-015021-pol2qm74 959 38 gut gut NN cord-015021-pol2qm74 959 39 barrier barrier NN cord-015021-pol2qm74 959 40 failure failure NN cord-015021-pol2qm74 959 41 and and CC cord-015021-pol2qm74 959 42 bacterial bacterial JJ cord-015021-pol2qm74 959 43 translocation translocation NN cord-015021-pol2qm74 959 44 , , , cord-015021-pol2qm74 959 45 in in IN cord-015021-pol2qm74 959 46 hypovolemic hypovolemic JJ cord-015021-pol2qm74 959 47 conditions condition NNS cord-015021-pol2qm74 959 48 . . . cord-015021-pol2qm74 960 1 Bacterial bacterial JJ cord-015021-pol2qm74 960 2 infections infection NNS cord-015021-pol2qm74 960 3 still still RB cord-015021-pol2qm74 960 4 constitute constitute VBP cord-015021-pol2qm74 960 5 a a DT cord-015021-pol2qm74 960 6 major major JJ cord-015021-pol2qm74 960 7 cause cause NN cord-015021-pol2qm74 960 8 of of IN cord-015021-pol2qm74 960 9 morbidity morbidity NN cord-015021-pol2qm74 960 10 and and CC cord-015021-pol2qm74 960 11 mortality mortality NN cord-015021-pol2qm74 960 12 in in IN cord-015021-pol2qm74 960 13 patients patient NNS cord-015021-pol2qm74 960 14 with with IN cord-015021-pol2qm74 960 15 acute acute JJ cord-015021-pol2qm74 960 16 liver liver NN cord-015021-pol2qm74 960 17 failure failure NN cord-015021-pol2qm74 960 18 . . . cord-015021-pol2qm74 961 1 The the DT cord-015021-pol2qm74 961 2 present present JJ cord-015021-pol2qm74 961 3 study study NN cord-015021-pol2qm74 961 4 aimed aim VBN cord-015021-pol2qm74 961 5 at at IN cord-015021-pol2qm74 961 6 evaluating evaluate VBG cord-015021-pol2qm74 961 7 the the DT cord-015021-pol2qm74 961 8 effect effect NN cord-015021-pol2qm74 961 9 of of IN cord-015021-pol2qm74 961 10 ethylhydroxyethyl ethylhydroxyethyl NN cord-015021-pol2qm74 961 11 cellulose cellulose NN cord-015021-pol2qm74 961 12 ( ( -LRB- cord-015021-pol2qm74 961 13 EHEC EHEC NNP cord-015021-pol2qm74 961 14 ) ) -RRB- cord-015021-pol2qm74 961 15 on on IN cord-015021-pol2qm74 961 16 bacterial bacterial JJ cord-015021-pol2qm74 961 17 translocation translocation NN cord-015021-pol2qm74 961 18 following follow VBG cord-015021-pol2qm74 961 19 surgically surgically RB cord-015021-pol2qm74 961 20 induced induce VBN cord-015021-pol2qm74 961 21 acute acute JJ cord-015021-pol2qm74 961 22 liver liver NN cord-015021-pol2qm74 961 23 failure failure NN cord-015021-pol2qm74 961 24 . . . cord-015021-pol2qm74 962 1 Acute acute JJ cord-015021-pol2qm74 962 2 liver liver NN cord-015021-pol2qm74 962 3 failure failure NN cord-015021-pol2qm74 962 4 was be VBD cord-015021-pol2qm74 962 5 induced induce VBN cord-015021-pol2qm74 962 6 by by IN cord-015021-pol2qm74 962 7 subtotal subtotal NN cord-015021-pol2qm74 962 8 hepatectomy hepatectomy NNP cord-015021-pol2qm74 962 9 ( ( -LRB- cord-015021-pol2qm74 962 10 90 90 CD cord-015021-pol2qm74 962 11 % % NN cord-015021-pol2qm74 962 12 ) ) -RRB- cord-015021-pol2qm74 962 13 in in IN cord-015021-pol2qm74 962 14 the the DT cord-015021-pol2qm74 962 15 rat rat NN cord-015021-pol2qm74 962 16 . . . cord-015021-pol2qm74 963 1 Water water NN cord-015021-pol2qm74 963 2 - - HYPH cord-015021-pol2qm74 963 3 soluble soluble JJ cord-015021-pol2qm74 963 4 EHEC EHEC NNP cord-015021-pol2qm74 963 5 was be VBD cord-015021-pol2qm74 963 6 administered administer VBN cord-015021-pol2qm74 963 7 orally orally RB cord-015021-pol2qm74 963 8 1 1 CD cord-015021-pol2qm74 963 9 and and CC cord-015021-pol2qm74 963 10 12 12 CD cord-015021-pol2qm74 963 11 hours hour NNS cord-015021-pol2qm74 963 12 prior prior RB cord-015021-pol2qm74 963 13 to to IN cord-015021-pol2qm74 963 14 hepatectomy hepatectomy NNP cord-015021-pol2qm74 963 15 . . . cord-015021-pol2qm74 964 1 The the DT cord-015021-pol2qm74 964 2 incidence incidence NN cord-015021-pol2qm74 964 3 of of IN cord-015021-pol2qm74 964 4 bacterial bacterial JJ cord-015021-pol2qm74 964 5 translocation translocation NN cord-015021-pol2qm74 964 6 from from IN cord-015021-pol2qm74 964 7 the the DT cord-015021-pol2qm74 964 8 gut gut NN cord-015021-pol2qm74 964 9 to to IN cord-015021-pol2qm74 964 10 mesenteric mesenteric JJ cord-015021-pol2qm74 964 11 lymph lymph NN cord-015021-pol2qm74 964 12 nodes node NNS cord-015021-pol2qm74 964 13 ( ( -LRB- cord-015021-pol2qm74 964 14 MLNs MLNs NNP cord-015021-pol2qm74 964 15 ) ) -RRB- cord-015021-pol2qm74 964 16 and and CC cord-015021-pol2qm74 964 17 systemic systemic JJ cord-015021-pol2qm74 964 18 and and CC cord-015021-pol2qm74 964 19 portal portal JJ cord-015021-pol2qm74 964 20 circulation circulation NN cord-015021-pol2qm74 964 21 was be VBD cord-015021-pol2qm74 964 22 evaluated evaluate VBN cord-015021-pol2qm74 964 23 and and CC cord-015021-pol2qm74 964 24 the the DT cord-015021-pol2qm74 964 25 number number NN cord-015021-pol2qm74 964 26 of of IN cord-015021-pol2qm74 964 27 isolated isolate VBN cord-015021-pol2qm74 964 28 bacteria bacteria NNS cord-015021-pol2qm74 964 29 from from IN cord-015021-pol2qm74 964 30 these these DT cord-015021-pol2qm74 964 31 samples sample NNS cord-015021-pol2qm74 964 32 and and CC cord-015021-pol2qm74 964 33 from from IN cord-015021-pol2qm74 964 34 intestinal intestinal JJ cord-015021-pol2qm74 964 35 content content NN cord-015021-pol2qm74 964 36 were be VBD cord-015021-pol2qm74 964 37 determined determine VBN cord-015021-pol2qm74 964 38 . . . cord-015021-pol2qm74 965 1 Intestinal intestinal JJ cord-015021-pol2qm74 965 2 transit transit NN cord-015021-pol2qm74 965 3 time time NN cord-015021-pol2qm74 965 4 , , , cord-015021-pol2qm74 965 5 bacterial bacterial JJ cord-015021-pol2qm74 965 6 adherence adherence NN cord-015021-pol2qm74 965 7 onto onto IN cord-015021-pol2qm74 965 8 the the DT cord-015021-pol2qm74 965 9 intestinal intestinal JJ cord-015021-pol2qm74 965 10 surface surface NN cord-015021-pol2qm74 965 11 , , , cord-015021-pol2qm74 965 12 intestinal intestinal JJ cord-015021-pol2qm74 965 13 mucosal mucosal JJ cord-015021-pol2qm74 965 14 mass mass NN cord-015021-pol2qm74 965 15 , , , cord-015021-pol2qm74 965 16 bacterial bacterial JJ cord-015021-pol2qm74 965 17 growth growth NN cord-015021-pol2qm74 965 18 and and CC cord-015021-pol2qm74 965 19 DNA dna NN cord-015021-pol2qm74 965 20 synthesis synthesis NN cord-015021-pol2qm74 965 21 , , , cord-015021-pol2qm74 965 22 bacterial bacterial JJ cord-015021-pol2qm74 965 23 surface surface NN cord-015021-pol2qm74 965 24 characteristics characteristic NNS cord-015021-pol2qm74 965 25 ( ( -LRB- cord-015021-pol2qm74 965 26 hydrobiology hydrobiology NN cord-015021-pol2qm74 965 27 : : : cord-015021-pol2qm74 965 28 hydrophobicity hydrophobicity NN cord-015021-pol2qm74 965 29 , , , cord-015021-pol2qm74 965 30 hydrophilicity hydrophilicity NN cord-015021-pol2qm74 965 31 and and CC cord-015021-pol2qm74 965 32 neutrality neutrality NN cord-015021-pol2qm74 965 33 ; ; : cord-015021-pol2qm74 965 34 surface surface NN cord-015021-pol2qm74 965 35 charges charge NNS cord-015021-pol2qm74 965 36 : : : cord-015021-pol2qm74 965 37 positive positive JJ cord-015021-pol2qm74 965 38 , , , cord-015021-pol2qm74 965 39 negative negative JJ cord-015021-pol2qm74 965 40 and and CC cord-015021-pol2qm74 965 41 neutral neutral JJ cord-015021-pol2qm74 965 42 ) ) -RRB- cord-015021-pol2qm74 965 43 were be VBD cord-015021-pol2qm74 965 44 also also RB cord-015021-pol2qm74 965 45 determined determine VBN cord-015021-pol2qm74 965 46 . . . cord-015021-pol2qm74 966 1 Hepatectomized hepatectomized JJ cord-015021-pol2qm74 966 2 animals animal NNS cord-015021-pol2qm74 966 3 showed show VBD cord-015021-pol2qm74 966 4 a a DT cord-015021-pol2qm74 966 5 80 80 CD cord-015021-pol2qm74 966 6 - - SYM cord-015021-pol2qm74 966 7 100 100 CD cord-015021-pol2qm74 966 8 % % NN cord-015021-pol2qm74 966 9 translocation translocation NN cord-015021-pol2qm74 966 10 rate rate NN cord-015021-pol2qm74 966 11 to to IN cord-015021-pol2qm74 966 12 MLNs mln NNS cord-015021-pol2qm74 966 13 or or CC cord-015021-pol2qm74 966 14 blood blood NN cord-015021-pol2qm74 966 15 2 2 CD cord-015021-pol2qm74 966 16 and and CC cord-015021-pol2qm74 966 17 4 4 CD cord-015021-pol2qm74 966 18 hours hour NNS cord-015021-pol2qm74 966 19 after after IN cord-015021-pol2qm74 966 20 operation operation NN cord-015021-pol2qm74 966 21 , , , cord-015021-pol2qm74 966 22 while while IN cord-015021-pol2qm74 966 23 only only RB cord-015021-pol2qm74 966 24 0 0 CD cord-015021-pol2qm74 966 25 - - SYM cord-015021-pol2qm74 966 26 1 1 CD cord-015021-pol2qm74 966 27 % % NN cord-015021-pol2qm74 966 28 of of IN cord-015021-pol2qm74 966 29 rats rat NNS cord-015021-pol2qm74 966 30 subjected subject VBN cord-015021-pol2qm74 966 31 to to IN cord-015021-pol2qm74 966 32 sham sham JJ cord-015021-pol2qm74 966 33 operation operation NN cord-015021-pol2qm74 966 34 or or CC cord-015021-pol2qm74 966 35 animals animal NNS cord-015021-pol2qm74 966 36 with with IN cord-015021-pol2qm74 966 37 90 90 CD cord-015021-pol2qm74 966 38 % % NN cord-015021-pol2qm74 966 39 hepatectomy hepatectomy NN cord-015021-pol2qm74 966 40 and and CC cord-015021-pol2qm74 966 41 pre pre JJ cord-015021-pol2qm74 966 42 - - NN cord-015021-pol2qm74 966 43 treatment treatment NN cord-015021-pol2qm74 966 44 with with IN cord-015021-pol2qm74 966 45 EHEC EHEC NNP cord-015021-pol2qm74 966 46 ( ( -LRB- cord-015021-pol2qm74 966 47 p p NN cord-015021-pol2qm74 966 48 < < XX cord-015021-pol2qm74 966 49 0.01 0.01 CD cord-015021-pol2qm74 966 50 ) ) -RRB- cord-015021-pol2qm74 966 51 . . . cord-015021-pol2qm74 967 1 Bacterial bacterial JJ cord-015021-pol2qm74 967 2 overgrowth overgrowth NN cord-015021-pol2qm74 967 3 , , , cord-015021-pol2qm74 967 4 increased increase VBN cord-015021-pol2qm74 967 5 bacterial bacterial JJ cord-015021-pol2qm74 967 6 adherence adherence NN cord-015021-pol2qm74 967 7 onto onto IN cord-015021-pol2qm74 967 8 the the DT cord-015021-pol2qm74 967 9 intestinal intestinal JJ cord-015021-pol2qm74 967 10 surface surface NN cord-015021-pol2qm74 967 11 as as RB cord-015021-pol2qm74 967 12 well well RB cord-015021-pol2qm74 967 13 as as IN cord-015021-pol2qm74 967 14 decreased decrease VBN cord-015021-pol2qm74 967 15 intestinal intestinal JJ cord-015021-pol2qm74 967 16 mucosal mucosal JJ cord-015021-pol2qm74 967 17 masses masse NNS cord-015021-pol2qm74 967 18 were be VBD cord-015021-pol2qm74 967 19 observed observe VBN cord-015021-pol2qm74 967 20 in in IN cord-015021-pol2qm74 967 21 animals animal NNS cord-015021-pol2qm74 967 22 with with IN cord-015021-pol2qm74 967 23 subtotal subtotal NN cord-015021-pol2qm74 967 24 liver liver NN cord-015021-pol2qm74 967 25 resection resection NN cord-015021-pol2qm74 967 26 alone alone RB cord-015021-pol2qm74 967 27 , , , cord-015021-pol2qm74 967 28 alterations alteration NNS cord-015021-pol2qm74 967 29 that that WDT cord-015021-pol2qm74 967 30 were be VBD cord-015021-pol2qm74 967 31 prevented prevent VBN cord-015021-pol2qm74 967 32 by by IN cord-015021-pol2qm74 967 33 enteral enteral JJ cord-015021-pol2qm74 967 34 EHEC EHEC NNP cord-015021-pol2qm74 967 35 treatment treatment NN cord-015021-pol2qm74 967 36 . . . cord-015021-pol2qm74 968 1 A a DT cord-015021-pol2qm74 968 2 delay delay NN cord-015021-pol2qm74 968 3 in in IN cord-015021-pol2qm74 968 4 intestinal intestinal JJ cord-015021-pol2qm74 968 5 2-hour 2-hour CD cord-015021-pol2qm74 968 6 transit transit NN cord-015021-pol2qm74 968 7 time time NN cord-015021-pol2qm74 968 8 occurred occur VBD cord-015021-pol2qm74 968 9 in in IN cord-015021-pol2qm74 968 10 both both DT cord-015021-pol2qm74 968 11 groups group NNS cord-015021-pol2qm74 968 12 with with IN cord-015021-pol2qm74 968 13 subtotal subtotal NN cord-015021-pol2qm74 968 14 liver liver NN cord-015021-pol2qm74 968 15 resection resection NN cord-015021-pol2qm74 968 16 , , , cord-015021-pol2qm74 968 17 with with IN cord-015021-pol2qm74 968 18 or or CC cord-015021-pol2qm74 968 19 without without IN cord-015021-pol2qm74 968 20 enteral enteral JJ cord-015021-pol2qm74 968 21 EHEC EHEC NNP cord-015021-pol2qm74 968 22 . . . cord-015021-pol2qm74 969 1 EHEC EHEC NNP cord-015021-pol2qm74 969 2 inhibited inhibit VBD cord-015021-pol2qm74 969 3 bacterial bacterial JJ cord-015021-pol2qm74 969 4 growth growth NN cord-015021-pol2qm74 969 5 and and CC cord-015021-pol2qm74 969 6 DNA dna NN cord-015021-pol2qm74 969 7 synthesis synthesis NN cord-015021-pol2qm74 969 8 , , , cord-015021-pol2qm74 969 9 and and CC cord-015021-pol2qm74 969 10 altered alter VBN cord-015021-pol2qm74 969 11 bacterial bacterial JJ cord-015021-pol2qm74 969 12 surface surface NN cord-015021-pol2qm74 969 13 properties property NNS cord-015021-pol2qm74 969 14 following follow VBG cord-015021-pol2qm74 969 15 1hour 1hour CD cord-015021-pol2qm74 969 16 incubation incubation NN cord-015021-pol2qm74 969 17 with with IN cord-015021-pol2qm74 969 18 bacteria bacteria NNS cord-015021-pol2qm74 969 19 . . . cord-015021-pol2qm74 970 1 In in IN cord-015021-pol2qm74 970 2 conclusion conclusion NN cord-015021-pol2qm74 970 3 , , , cord-015021-pol2qm74 970 4 the the DT cord-015021-pol2qm74 970 5 findings finding NNS cord-015021-pol2qm74 970 6 in in IN cord-015021-pol2qm74 970 7 the the DT cord-015021-pol2qm74 970 8 present present JJ cord-015021-pol2qm74 970 9 study study NN cord-015021-pol2qm74 970 10 imply imply VBP cord-015021-pol2qm74 970 11 that that IN cord-015021-pol2qm74 970 12 EHEC EHEC NNP cord-015021-pol2qm74 970 13 alters alter VBZ cord-015021-pol2qm74 970 14 enterobacterial enterobacterial JJ cord-015021-pol2qm74 970 15 capacities capacity NNS cord-015021-pol2qm74 970 16 for for IN cord-015021-pol2qm74 970 17 metabolism metabolism NN cord-015021-pol2qm74 970 18 , , , cord-015021-pol2qm74 970 19 proliferation proliferation NN cord-015021-pol2qm74 970 20 and and CC cord-015021-pol2qm74 970 21 invasion invasion NN cord-015021-pol2qm74 970 22 by by IN cord-015021-pol2qm74 970 23 effects effect NNS cord-015021-pol2qm74 970 24 on on IN cord-015021-pol2qm74 970 25 e.g. e.g. JJ cord-015021-pol2qm74 970 26 bacterial bacterial JJ cord-015021-pol2qm74 970 27 surface surface NN cord-015021-pol2qm74 970 28 characteristics characteristic NNS cord-015021-pol2qm74 970 29 . . . cord-015021-pol2qm74 971 1 Furthermore furthermore RB cord-015021-pol2qm74 971 2 , , , cord-015021-pol2qm74 971 3 EHEC EHEC NNP cord-015021-pol2qm74 971 4 seems seem VBZ cord-015021-pol2qm74 971 5 to to TO cord-015021-pol2qm74 971 6 possess possess VB cord-015021-pol2qm74 971 7 a a DT cord-015021-pol2qm74 971 8 trophic trophic JJ cord-015021-pol2qm74 971 9 action action NN cord-015021-pol2qm74 971 10 on on IN cord-015021-pol2qm74 971 11 the the DT cord-015021-pol2qm74 971 12 intestine intestine NN cord-015021-pol2qm74 971 13 , , , cord-015021-pol2qm74 971 14 rather rather RB cord-015021-pol2qm74 971 15 than than IN cord-015021-pol2qm74 971 16 exerting exert VBG cord-015021-pol2qm74 971 17 its -PRON- PRP$ cord-015021-pol2qm74 971 18 effect effect NN cord-015021-pol2qm74 971 19 by by IN cord-015021-pol2qm74 971 20 enhancing enhance VBG cord-015021-pol2qm74 971 21 intestinal intestinal JJ cord-015021-pol2qm74 971 22 motility motility NN cord-015021-pol2qm74 971 23 . . . cord-015021-pol2qm74 972 1 Department Department NNP cord-015021-pol2qm74 972 2 of of IN cord-015021-pol2qm74 972 3 Surgery Surgery NNP cord-015021-pol2qm74 972 4 , , , cord-015021-pol2qm74 972 5 Lund Lund NNP cord-015021-pol2qm74 972 6 University University NNP cord-015021-pol2qm74 972 7 Hospital Hospital NNP cord-015021-pol2qm74 972 8 , , , cord-015021-pol2qm74 972 9 S-221 s-221 NN cord-015021-pol2qm74 972 10 85 85 CD cord-015021-pol2qm74 972 11 Lund Lund NNP cord-015021-pol2qm74 972 12 , , , cord-015021-pol2qm74 972 13 Sweden Sweden NNP cord-015021-pol2qm74 972 14 Disturbances Disturbances NNPS cord-015021-pol2qm74 972 15 in in IN cord-015021-pol2qm74 972 16 intracellular intracellular JJ cord-015021-pol2qm74 972 17 calcium calcium NN cord-015021-pol2qm74 972 18 signalling signalling NN cord-015021-pol2qm74 972 19 can can MD cord-015021-pol2qm74 972 20 potentially potentially RB cord-015021-pol2qm74 972 21 result result VB cord-015021-pol2qm74 972 22 in in IN cord-015021-pol2qm74 972 23 impairments impairment NNS cord-015021-pol2qm74 972 24 of of IN cord-015021-pol2qm74 972 25 cellular cellular JJ cord-015021-pol2qm74 972 26 responses response NNS cord-015021-pol2qm74 972 27 vital vital JJ cord-015021-pol2qm74 972 28 to to IN cord-015021-pol2qm74 972 29 the the DT cord-015021-pol2qm74 972 30 functional functional JJ cord-015021-pol2qm74 972 31 integrity integrity NN cord-015021-pol2qm74 972 32 of of IN cord-015021-pol2qm74 972 33 both both DT cord-015021-pol2qm74 972 34 immune immune JJ cord-015021-pol2qm74 972 35 and and CC cord-015021-pol2qm74 972 36 non non JJ cord-015021-pol2qm74 972 37 - - JJ cord-015021-pol2qm74 972 38 immune immune JJ cord-015021-pol2qm74 972 39 cells cell NNS cord-015021-pol2qm74 972 40 , , , cord-015021-pol2qm74 972 41 and and CC cord-015021-pol2qm74 972 42 thus thus RB cord-015021-pol2qm74 972 43 contribute contribute VB cord-015021-pol2qm74 972 44 to to IN cord-015021-pol2qm74 972 45 a a DT cord-015021-pol2qm74 972 46 decrease decrease NN cord-015021-pol2qm74 972 47 in in IN cord-015021-pol2qm74 972 48 host host NN cord-015021-pol2qm74 972 49 resistance resistance NN cord-015021-pol2qm74 972 50 against against IN cord-015021-pol2qm74 972 51 infection infection NN cord-015021-pol2qm74 972 52 and and CC cord-015021-pol2qm74 972 53 to to IN cord-015021-pol2qm74 972 54 multiple multiple JJ cord-015021-pol2qm74 972 55 organ organ NN cord-015021-pol2qm74 972 56 system system NN cord-015021-pol2qm74 972 57 failure failure NN cord-015021-pol2qm74 972 58 during during IN cord-015021-pol2qm74 972 59 sepsis sepsis NN cord-015021-pol2qm74 972 60 . . . cord-015021-pol2qm74 973 1 Studies study NNS cord-015021-pol2qm74 973 2 in in IN cord-015021-pol2qm74 973 3 our -PRON- PRP$ cord-015021-pol2qm74 973 4 laboratory laboratory NN cord-015021-pol2qm74 973 5 have have VBP cord-015021-pol2qm74 973 6 focused focus VBN cord-015021-pol2qm74 973 7 on on IN cord-015021-pol2qm74 973 8 assessments assessment NNS cord-015021-pol2qm74 973 9 of of IN cord-015021-pol2qm74 973 10 intracellular intracellular JJ cord-015021-pol2qm74 973 11 Ca Ca NNP cord-015021-pol2qm74 973 12 2÷ 2÷ CD cord-015021-pol2qm74 973 13 regulation regulation NN cord-015021-pol2qm74 973 14 and and CC cord-015021-pol2qm74 973 15 Ca~+-depended Ca~+-depended NNP cord-015021-pol2qm74 973 16 cellular cellular JJ cord-015021-pol2qm74 973 17 responses response NNS cord-015021-pol2qm74 973 18 in in IN cord-015021-pol2qm74 973 19 the the DT cord-015021-pol2qm74 973 20 liver liver NN cord-015021-pol2qm74 973 21 , , , cord-015021-pol2qm74 973 22 skeletal skeletal JJ cord-015021-pol2qm74 973 23 muscle muscle NN cord-015021-pol2qm74 973 24 and and CC cord-015021-pol2qm74 973 25 splenic splenic JJ cord-015021-pol2qm74 973 26 Tlymphocytes Tlymphocytes NNPS cord-015021-pol2qm74 973 27 harvested harvest VBN cord-015021-pol2qm74 973 28 from from IN cord-015021-pol2qm74 973 29 rats rat NNS cord-015021-pol2qm74 973 30 subjected subject VBN cord-015021-pol2qm74 973 31 to to IN cord-015021-pol2qm74 973 32 gram gram NN cord-015021-pol2qm74 973 33 - - HYPH cord-015021-pol2qm74 973 34 negative negative JJ cord-015021-pol2qm74 973 35 intraabdominal intraabdominal JJ cord-015021-pol2qm74 973 36 sepsis sepsis NN cord-015021-pol2qm74 973 37 . . . cord-015021-pol2qm74 974 1 Cytosolic Cytosolic NNP cord-015021-pol2qm74 975 1 Ca ca NN cord-015021-pol2qm74 975 2 2 2 CD cord-015021-pol2qm74 975 3 + + CC cord-015021-pol2qm74 975 4 concentration concentration NN cord-015021-pol2qm74 975 5 , , , cord-015021-pol2qm74 975 6 [ [ -LRB- cord-015021-pol2qm74 975 7 Ca2*]i Ca2*]i NNP cord-015021-pol2qm74 975 8 , , , cord-015021-pol2qm74 975 9 and and CC cord-015021-pol2qm74 976 1 Ca ca NN cord-015021-pol2qm74 976 2 2 2 CD cord-015021-pol2qm74 976 3 + + CD cord-015021-pol2qm74 976 4 fluxes flux NNS cord-015021-pol2qm74 976 5 were be VBD cord-015021-pol2qm74 976 6 measured measure VBN cord-015021-pol2qm74 976 7 by by IN cord-015021-pol2qm74 976 8 the the DT cord-015021-pol2qm74 976 9 use use NN cord-015021-pol2qm74 976 10 of of IN cord-015021-pol2qm74 976 11 fluorescent fluorescent NN cord-015021-pol2qm74 977 1 Ca ca NN cord-015021-pol2qm74 977 2 2 2 CD cord-015021-pol2qm74 977 3 + + SYM cord-015021-pol2qm74 977 4 chelating chelating NN cord-015021-pol2qm74 977 5 dyes dye NNS cord-015021-pol2qm74 977 6 ( ( -LRB- cord-015021-pol2qm74 977 7 Fura-2 Fura-2 NNP cord-015021-pol2qm74 977 8 or or CC cord-015021-pol2qm74 977 9 indo-1 indo-1 NNP cord-015021-pol2qm74 977 10 ) ) -RRB- cord-015021-pol2qm74 977 11 and and CC cord-015021-pol2qm74 977 12 45 45 CD cord-015021-pol2qm74 977 13 Ca Ca MD cord-015021-pol2qm74 977 14 respectively respectively RB cord-015021-pol2qm74 977 15 . . . cord-015021-pol2qm74 978 1 To to TO cord-015021-pol2qm74 978 2 assess assess VB cord-015021-pol2qm74 978 3 sepsis sepsis NN cord-015021-pol2qm74 978 4 - - HYPH cord-015021-pol2qm74 978 5 related relate VBN cord-015021-pol2qm74 978 6 changes change NNS cord-015021-pol2qm74 978 7 in in IN cord-015021-pol2qm74 978 8 Ca Ca NNP cord-015021-pol2qm74 978 9 2 2 CD cord-015021-pol2qm74 978 10 + + CC cord-015021-pol2qm74 978 11 dependent dependent JJ cord-015021-pol2qm74 978 12 cellular cellular JJ cord-015021-pol2qm74 978 13 responses response NNS cord-015021-pol2qm74 978 14 , , , cord-015021-pol2qm74 978 15 we -PRON- PRP cord-015021-pol2qm74 978 16 measured measure VBD cord-015021-pol2qm74 978 17 the the DT cord-015021-pol2qm74 978 18 acute acute JJ cord-015021-pol2qm74 978 19 phase phase NN cord-015021-pol2qm74 978 20 protein protein NN cord-015021-pol2qm74 978 21 response response NN cord-015021-pol2qm74 978 22 in in IN cord-015021-pol2qm74 978 23 the the DT cord-015021-pol2qm74 978 24 liver liver NN cord-015021-pol2qm74 978 25 , , , cord-015021-pol2qm74 978 26 the the DT cord-015021-pol2qm74 978 27 regulation regulation NN cord-015021-pol2qm74 978 28 of of IN cord-015021-pol2qm74 978 29 protein protein NN cord-015021-pol2qm74 978 30 and and CC cord-015021-pol2qm74 978 31 sugar sugar NN cord-015021-pol2qm74 978 32 metabolism metabolism NN cord-015021-pol2qm74 978 33 in in IN cord-015021-pol2qm74 978 34 the the DT cord-015021-pol2qm74 978 35 skeletal skeletal JJ cord-015021-pol2qm74 978 36 muscle muscle NN cord-015021-pol2qm74 978 37 , , , cord-015021-pol2qm74 978 38 and and CC cord-015021-pol2qm74 978 39 the the DT cord-015021-pol2qm74 978 40 proliferation proliferation NN cord-015021-pol2qm74 978 41 response response NN cord-015021-pol2qm74 978 42 in in IN cord-015021-pol2qm74 978 43 the the DT cord-015021-pol2qm74 978 44 splenic splenic JJ cord-015021-pol2qm74 978 45 Tlymphocytes Tlymphocytes NNPS cord-015021-pol2qm74 978 46 . . . cord-015021-pol2qm74 979 1 Altered alter VBN cord-015021-pol2qm74 979 2 Ca2 ca2 CD cord-015021-pol2qm74 980 1 + + CC cord-015021-pol2qm74 981 1 i i PRP cord-015021-pol2qm74 981 2 signalling signal VBG cord-015021-pol2qm74 981 3 with with IN cord-015021-pol2qm74 981 4 sepsis sepsis NN cord-015021-pol2qm74 981 5 was be VBD cord-015021-pol2qm74 981 6 correlated correlate VBN cord-015021-pol2qm74 981 7 with with IN cord-015021-pol2qm74 981 8 an an DT cord-015021-pol2qm74 981 9 exaggerated exaggerated JJ cord-015021-pol2qm74 981 10 inappropriate inappropriate JJ cord-015021-pol2qm74 981 11 acute acute JJ cord-015021-pol2qm74 981 12 phase phase NN cord-015021-pol2qm74 981 13 protein protein NN cord-015021-pol2qm74 981 14 response response NN cord-015021-pol2qm74 981 15 ( ( -LRB- cord-015021-pol2qm74 981 16 100 100 CD cord-015021-pol2qm74 981 17 % % NN cord-015021-pol2qm74 981 18 ¢ ¢ NNP cord-015021-pol2qm74 981 19 ) ) -RRB- cord-015021-pol2qm74 981 20 in in IN cord-015021-pol2qm74 981 21 the the DT cord-015021-pol2qm74 981 22 liver liver NN cord-015021-pol2qm74 981 23 , , , cord-015021-pol2qm74 981 24 and and CC cord-015021-pol2qm74 981 25 a a DT cord-015021-pol2qm74 981 26 blunted blunt VBN cord-015021-pol2qm74 981 27 insulin insulin NN cord-015021-pol2qm74 981 28 mediated mediate VBN cord-015021-pol2qm74 981 29 sugar sugar NN cord-015021-pol2qm74 981 30 utilization utilization NN cord-015021-pol2qm74 981 31 ( ( -LRB- cord-015021-pol2qm74 981 32 60 60 CD cord-015021-pol2qm74 981 33 % % NN cord-015021-pol2qm74 981 34 4 4 CD cord-015021-pol2qm74 981 35 ) ) -RRB- cord-015021-pol2qm74 981 36 and and CC cord-015021-pol2qm74 981 37 increased increase VBN cord-015021-pol2qm74 981 38 proteolysis proteolysis NN cord-015021-pol2qm74 981 39 ( ( -LRB- cord-015021-pol2qm74 981 40 50 50 CD cord-015021-pol2qm74 981 41 % % NN cord-015021-pol2qm74 981 42 ~ ~ CD cord-015021-pol2qm74 981 43 ) ) -RRB- cord-015021-pol2qm74 981 44 in in IN cord-015021-pol2qm74 981 45 the the DT cord-015021-pol2qm74 981 46 skeletal skeletal JJ cord-015021-pol2qm74 981 47 muscle muscle NN cord-015021-pol2qm74 981 48 . . . cord-015021-pol2qm74 982 1 In in IN cord-015021-pol2qm74 982 2 T t NN cord-015021-pol2qm74 982 3 - - HYPH cord-015021-pol2qm74 982 4 lymphocytes lymphocyte NNS cord-015021-pol2qm74 982 5 , , , cord-015021-pol2qm74 982 6 a a DT cord-015021-pol2qm74 982 7 decrease decrease NN cord-015021-pol2qm74 982 8 in in IN cord-015021-pol2qm74 982 9 mitogen mitogen NNP cord-015021-pol2qm74 982 10 induced induce VBN cord-015021-pol2qm74 982 11 elevation elevation NN cord-015021-pol2qm74 982 12 of of IN cord-015021-pol2qm74 982 13 [ [ -LRB- cord-015021-pol2qm74 982 14 Ca2+]i Ca2+]i NNP cord-015021-pol2qm74 982 15 by by IN cord-015021-pol2qm74 982 16 35 35 CD cord-015021-pol2qm74 982 17 - - SYM cord-015021-pol2qm74 982 18 40 40 CD cord-015021-pol2qm74 982 19 % % NN cord-015021-pol2qm74 982 20 was be VBD cord-015021-pol2qm74 982 21 correlated correlate VBN cord-015021-pol2qm74 982 22 with with IN cord-015021-pol2qm74 982 23 a a DT cord-015021-pol2qm74 982 24 significant significant JJ cord-015021-pol2qm74 982 25 depression depression NN cord-015021-pol2qm74 982 26 in in IN cord-015021-pol2qm74 982 27 their -PRON- PRP$ cord-015021-pol2qm74 982 28 proliferative proliferative JJ cord-015021-pol2qm74 982 29 capacity capacity NN cord-015021-pol2qm74 982 30 . . . cord-015021-pol2qm74 983 1 These these DT cord-015021-pol2qm74 983 2 studies study NNS cord-015021-pol2qm74 983 3 clearly clearly RB cord-015021-pol2qm74 983 4 suggest suggest VBP cord-015021-pol2qm74 983 5 that that IN cord-015021-pol2qm74 983 6 altered alter VBN cord-015021-pol2qm74 983 7 calcium calcium NN cord-015021-pol2qm74 983 8 signalling signalling NN cord-015021-pol2qm74 983 9 is be VBZ cord-015021-pol2qm74 983 10 correlated correlate VBN cord-015021-pol2qm74 983 11 with with IN cord-015021-pol2qm74 983 12 disturbances disturbance NNS cord-015021-pol2qm74 983 13 in in IN cord-015021-pol2qm74 983 14 cellular cellular JJ cord-015021-pol2qm74 983 15 responses response NNS cord-015021-pol2qm74 983 16 in in IN cord-015021-pol2qm74 983 17 both both DT cord-015021-pol2qm74 983 18 immune immune JJ cord-015021-pol2qm74 983 19 and and CC cord-015021-pol2qm74 983 20 non non JJ cord-015021-pol2qm74 983 21 - - JJ cord-015021-pol2qm74 983 22 immune immune JJ cord-015021-pol2qm74 983 23 cells cell NNS cord-015021-pol2qm74 983 24 during during IN cord-015021-pol2qm74 983 25 sepsis sepsis NN cord-015021-pol2qm74 983 26 . . . cord-015021-pol2qm74 984 1 The the DT cord-015021-pol2qm74 984 2 altered altered JJ cord-015021-pol2qm74 984 3 cellular cellular JJ cord-015021-pol2qm74 984 4 responses response NNS cord-015021-pol2qm74 984 5 adversely adversely RB cord-015021-pol2qm74 984 6 effect effect VBP cord-015021-pol2qm74 984 7 the the DT cord-015021-pol2qm74 984 8 outcome outcome NN cord-015021-pol2qm74 984 9 of of IN cord-015021-pol2qm74 984 10 the the DT cord-015021-pol2qm74 984 11 septic septic JJ cord-015021-pol2qm74 984 12 injury injury NN cord-015021-pol2qm74 984 13 . . . cord-015021-pol2qm74 985 1 ( ( -LRB- cord-015021-pol2qm74 985 2 Supported support VBN cord-015021-pol2qm74 985 3 by by IN cord-015021-pol2qm74 985 4 NIH NIH NNP cord-015021-pol2qm74 985 5 Grant Grant NNP cord-015021-pol2qm74 985 6 GM GM NNP cord-015021-pol2qm74 985 7 32288 32288 CD cord-015021-pol2qm74 985 8 ) ) -RRB- cord-015021-pol2qm74 985 9 . . . cord-015021-pol2qm74 986 1 Alfred Alfred NNP cord-015021-pol2qm74 986 2 Ayala Ayala NNP cord-015021-pol2qm74 986 3 , , , cord-015021-pol2qm74 986 4 Ping Ping NNP cord-015021-pol2qm74 986 5 Wang Wang NNP cord-015021-pol2qm74 986 6 and and CC cord-015021-pol2qm74 986 7 Irshad Irshad NNP cord-015021-pol2qm74 986 8 H. H. NNP cord-015021-pol2qm74 986 9 Chaudry Chaudry NNP cord-015021-pol2qm74 986 10 . . . cord-015021-pol2qm74 987 1 Changes change NNS cord-015021-pol2qm74 987 2 in in IN cord-015021-pol2qm74 987 3 macrophage macrophage NN cord-015021-pol2qm74 987 4 capacity capacity NN cord-015021-pol2qm74 987 5 to to TO cord-015021-pol2qm74 987 6 respond respond VB cord-015021-pol2qm74 987 7 to to IN cord-015021-pol2qm74 987 8 foreign foreign JJ cord-015021-pol2qm74 987 9 pathogens pathogen NNS cord-015021-pol2qm74 987 10 are be VBP cord-015021-pol2qm74 987 11 thought think VBN cord-015021-pol2qm74 987 12 to to TO cord-015021-pol2qm74 987 13 be be VB cord-015021-pol2qm74 987 14 central central JJ cord-015021-pol2qm74 987 15 to to IN cord-015021-pol2qm74 987 16 the the DT cord-015021-pol2qm74 987 17 developing develop VBG cord-015021-pol2qm74 987 18 immunosuppression immunosuppression NN cord-015021-pol2qm74 987 19 associated associate VBN cord-015021-pol2qm74 987 20 with with IN cord-015021-pol2qm74 987 21 traumatic traumatic JJ cord-015021-pol2qm74 987 22 injury injury NN cord-015021-pol2qm74 987 23 . . . cord-015021-pol2qm74 988 1 In in IN cord-015021-pol2qm74 988 2 this this DT cord-015021-pol2qm74 988 3 respect respect NN cord-015021-pol2qm74 988 4 , , , cord-015021-pol2qm74 988 5 the the DT cord-015021-pol2qm74 988 6 suppression suppression NN cord-015021-pol2qm74 988 7 seen see VBN cord-015021-pol2qm74 988 8 in in IN cord-015021-pol2qm74 988 9 M~ M~ NNP cord-015021-pol2qm74 988 10 functions function NNS cord-015021-pol2qm74 988 11 following follow VBG cord-015021-pol2qm74 988 12 HEN HEN NNP cord-015021-pol2qm74 988 13 ( ( -LRB- cord-015021-pol2qm74 988 14 a a DT cord-015021-pol2qm74 988 15 common common JJ cord-015021-pol2qm74 988 16 component component NN cord-015021-pol2qm74 988 17 of of IN cord-015021-pol2qm74 988 18 traumatic traumatic JJ cord-015021-pol2qm74 988 19 injury injury NN cord-015021-pol2qm74 988 20 ) ) -RRB- cord-015021-pol2qm74 988 21 may may MD cord-015021-pol2qm74 988 22 be be VB cord-015021-pol2qm74 988 23 mediated mediate VBN cord-015021-pol2qm74 988 24 by by IN cord-015021-pol2qm74 988 25 the the DT cord-015021-pol2qm74 988 26 direct direct JJ cord-015021-pol2qm74 988 27 or or CC cord-015021-pol2qm74 988 28 indirect indirect JJ cord-015021-pol2qm74 988 29 inhibition inhibition NN cord-015021-pol2qm74 988 30 of of IN cord-015021-pol2qm74 988 31 their -PRON- PRP$ cord-015021-pol2qm74 988 32 capacity capacity NN cord-015021-pol2qm74 988 33 to to TO cord-015021-pol2qm74 988 34 perceive perceive VB cord-015021-pol2qm74 988 35 external external JJ cord-015021-pol2qm74 988 36 stimuli stimulus NNS cord-015021-pol2qm74 988 37 ( ( -LRB- cord-015021-pol2qm74 988 38 e.g. e.g. RB cord-015021-pol2qm74 988 39 , , , cord-015021-pol2qm74 988 40 opsonized opsonize VBN cord-015021-pol2qm74 988 41 & & CC cord-015021-pol2qm74 988 42 non non JJ cord-015021-pol2qm74 988 43 - - JJ cord-015021-pol2qm74 988 44 opsonized opsonized JJ cord-015021-pol2qm74 988 45 bacteria bacteria NNS cord-015021-pol2qm74 988 46 , , , cord-015021-pol2qm74 988 47 and and CC cord-015021-pol2qm74 988 48 their -PRON- PRP$ cord-015021-pol2qm74 988 49 cellular cellular JJ cord-015021-pol2qm74 988 50 components component NNS cord-015021-pol2qm74 988 51 , , , cord-015021-pol2qm74 988 52 etc etc FW cord-015021-pol2qm74 988 53 . . . cord-015021-pol2qm74 988 54 } } -RRB- cord-015021-pol2qm74 989 1 due due IN cord-015021-pol2qm74 989 2 to to IN cord-015021-pol2qm74 989 3 the the DT cord-015021-pol2qm74 989 4 breakdown breakdown NN cord-015021-pol2qm74 989 5 of of IN cord-015021-pol2qm74 989 6 the the DT cord-015021-pol2qm74 989 7 receptormediated receptormediated JJ cord-015021-pol2qm74 989 8 signal signal NN cord-015021-pol2qm74 989 9 transduction transduction NN cord-015021-pol2qm74 989 10 system system NN cord-015021-pol2qm74 989 11 . . . cord-015021-pol2qm74 990 1 Results result NNS cord-015021-pol2qm74 990 2 of of IN cord-015021-pol2qm74 990 3 a a DT cord-015021-pol2qm74 990 4 number number NN cord-015021-pol2qm74 990 5 of of IN cord-015021-pol2qm74 990 6 studies study NNS cord-015021-pol2qm74 990 7 by by IN cord-015021-pol2qm74 990 8 our -PRON- PRP$ cord-015021-pol2qm74 990 9 laboratory laboratory NN cord-015021-pol2qm74 990 10 and and CC cord-015021-pol2qm74 990 11 others other NNS cord-015021-pol2qm74 990 12 indicate indicate VBP cord-015021-pol2qm74 990 13 that that IN cord-015021-pol2qm74 990 14 this this DT cord-015021-pol2qm74 990 15 inability inability NN cord-015021-pol2qm74 990 16 to to TO cord-015021-pol2qm74 990 17 respond respond VB cord-015021-pol2qm74 990 18 to to IN cord-015021-pol2qm74 990 19 external external JJ cord-015021-pol2qm74 990 20 stimuli stimulus NNS cord-015021-pol2qm74 990 21 is be VBZ cord-015021-pol2qm74 990 22 in in IN cord-015021-pol2qm74 990 23 part part NN cord-015021-pol2qm74 990 24 due due IN cord-015021-pol2qm74 990 25 to to IN cord-015021-pol2qm74 990 26 the the DT cord-015021-pol2qm74 990 27 loss loss NN cord-015021-pol2qm74 990 28 of of IN cord-015021-pol2qm74 990 29 cell cell NN cord-015021-pol2qm74 990 30 surface surface NN cord-015021-pol2qm74 990 31 receptors receptor NNS cord-015021-pol2qm74 990 32 . . . cord-015021-pol2qm74 991 1 Decreases decrease NNS cord-015021-pol2qm74 991 2 have have VBP cord-015021-pol2qm74 991 3 been be VBN cord-015021-pol2qm74 991 4 documented document VBN cord-015021-pol2qm74 991 5 for for IN cord-015021-pol2qm74 991 6 not not RB cord-015021-pol2qm74 991 7 only only RB cord-015021-pol2qm74 991 8 la la JJ cord-015021-pol2qm74 991 9 antigen antigen NNP cord-015021-pol2qm74 991 10 , , , cord-015021-pol2qm74 991 11 but but CC cord-015021-pol2qm74 991 12 also also RB cord-015021-pol2qm74 991 13 C3b C3b NNP cord-015021-pol2qm74 991 14 , , , cord-015021-pol2qm74 991 15 Fc Fc NNP cord-015021-pol2qm74 991 16 , , , cord-015021-pol2qm74 991 17 and and CC cord-015021-pol2qm74 991 18 TNF TNF NNP cord-015021-pol2qm74 991 19 receptors receptor NNS cord-015021-pol2qm74 991 20 following follow VBG cord-015021-pol2qm74 991 21 HEM HEM NNP cord-015021-pol2qm74 991 22 in in IN cord-015021-pol2qm74 991 23 mice mouse NNS cord-015021-pol2qm74 991 24 . . . cord-015021-pol2qm74 992 1 Furthermore furthermore RB cord-015021-pol2qm74 992 2 , , , cord-015021-pol2qm74 992 3 studies study NNS cord-015021-pol2qm74 992 4 which which WDT cord-015021-pol2qm74 992 5 have have VBP cord-015021-pol2qm74 992 6 examined examine VBN cord-015021-pol2qm74 992 7 second second JJ cord-015021-pol2qm74 992 8 messenger messenger NN cord-015021-pol2qm74 992 9 generation generation NN cord-015021-pol2qm74 992 10 in in IN cord-015021-pol2qm74 992 11 these these DT cord-015021-pol2qm74 992 12 cells cell NNS cord-015021-pol2qm74 992 13 indicate indicate VBP cord-015021-pol2qm74 992 14 that that IN cord-015021-pol2qm74 992 15 M~ M~ NNP cord-015021-pol2qm74 992 16 derived derive VBN cord-015021-pol2qm74 992 17 from from IN cord-015021-pol2qm74 992 18 the the DT cord-015021-pol2qm74 992 19 peritoneum peritoneum NN cord-015021-pol2qm74 992 20 and and CC cord-015021-pol2qm74 992 21 spleen spleen NNS cord-015021-pol2qm74 992 22 exhibit exhibit VBP cord-015021-pol2qm74 992 23 a a DT cord-015021-pol2qm74 992 24 decreased decrease VBN cord-015021-pol2qm74 992 25 capacity capacity NN cord-015021-pol2qm74 992 26 to to TO cord-015021-pol2qm74 992 27 mobilize mobilize VB cord-015021-pol2qm74 992 28 Ca Ca NNP cord-015021-pol2qm74 992 29 +2 +2 NN cord-015021-pol2qm74 992 30 from from IN cord-015021-pol2qm74 992 31 intracellular intracellular JJ cord-015021-pol2qm74 992 32 stores store NNS cord-015021-pol2qm74 992 33 . . . cord-015021-pol2qm74 993 1 This this DT cord-015021-pol2qm74 993 2 protein protein NN cord-015021-pol2qm74 993 3 kinase kinase VBZ cord-015021-pol2qm74 993 4 dependent dependent JJ cord-015021-pol2qm74 993 5 process process NN cord-015021-pol2qm74 993 6 of of IN cord-015021-pol2qm74 993 7 [ [ -LRB- cord-015021-pol2qm74 993 8 Ca+2 Ca+2 NNP cord-015021-pol2qm74 993 9 ] ] -RRB- cord-015021-pol2qm74 994 1 i i PRP cord-015021-pol2qm74 994 2 mobilization mobilization NN cord-015021-pol2qm74 994 3 appears appear VBZ cord-015021-pol2qm74 994 4 to to TO cord-015021-pol2qm74 994 5 be be VB cord-015021-pol2qm74 994 6 linked link VBN cord-015021-pol2qm74 994 7 to to IN cord-015021-pol2qm74 994 8 the the DT cord-015021-pol2qm74 994 9 inability inability NN cord-015021-pol2qm74 994 10 to to TO cord-015021-pol2qm74 994 11 synthesize synthesize VB cord-015021-pol2qm74 994 12 inositol inositol NN cord-015021-pol2qm74 994 13 triphosphate triphosphate NN cord-015021-pol2qm74 994 14 . . . cord-015021-pol2qm74 995 1 Of of IN cord-015021-pol2qm74 995 2 interest interest NN cord-015021-pol2qm74 995 3 , , , cord-015021-pol2qm74 995 4 the the DT cord-015021-pol2qm74 995 5 depression depression NN cord-015021-pol2qm74 995 6 in in IN cord-015021-pol2qm74 995 7 Ca Ca NNP cord-015021-pol2qm74 995 8 +2 +2 NN cord-015021-pol2qm74 995 9 signal signal JJ cord-015021-pol2qm74 995 10 generation generation NN cord-015021-pol2qm74 995 11 appears appear VBZ cord-015021-pol2qm74 995 12 to to TO cord-015021-pol2qm74 995 13 be be VB cord-015021-pol2qm74 995 14 inversely inversely RB cord-015021-pol2qm74 995 15 related relate VBN cord-015021-pol2qm74 995 16 to to IN cord-015021-pol2qm74 995 17 presence presence NN cord-015021-pol2qm74 995 18 of of IN cord-015021-pol2qm74 995 19 elevated elevated JJ cord-015021-pol2qm74 995 20 levels level NNS cord-015021-pol2qm74 995 21 of of IN cord-015021-pol2qm74 995 22 cAMP camp NN cord-015021-pol2qm74 995 23 in in IN cord-015021-pol2qm74 995 24 M~ M~ NNP cord-015021-pol2qm74 995 25 from from IN cord-015021-pol2qm74 995 26 HEN HEN NNP cord-015021-pol2qm74 995 27 mice mouse NNS cord-015021-pol2qm74 995 28 . . . cord-015021-pol2qm74 996 1 We -PRON- PRP cord-015021-pol2qm74 996 2 have have VBP cord-015021-pol2qm74 996 3 reported report VBN cord-015021-pol2qm74 996 4 that that IN cord-015021-pol2qm74 996 5 M~ m~ IN cord-015021-pol2qm74 996 6 priming prime VBG cord-015021-pol2qm74 996 7 agents agent NNS cord-015021-pol2qm74 996 8 , , , cord-015021-pol2qm74 996 9 such such JJ cord-015021-pol2qm74 996 10 as as IN cord-015021-pol2qm74 996 11 IFN-7 IFN-7 NNP cord-015021-pol2qm74 996 12 ( ( -LRB- cord-015021-pol2qm74 996 13 which which WDT cord-015021-pol2qm74 996 14 exhibits exhibit VBZ cord-015021-pol2qm74 996 15 salutary salutary JJ cord-015021-pol2qm74 996 16 effects effect NNS cord-015021-pol2qm74 996 17 on on IN cord-015021-pol2qm74 996 18 M~ m~ NN cord-015021-pol2qm74 996 19 function function NN cord-015021-pol2qm74 996 20 following follow VBG cord-015021-pol2qm74 996 21 HEM HEM NNP cord-015021-pol2qm74 996 22 ) ) -RRB- cord-015021-pol2qm74 996 23 , , , cord-015021-pol2qm74 996 24 appear appear VBP cord-015021-pol2qm74 996 25 to to TO cord-015021-pol2qm74 996 26 restore restore VB cord-015021-pol2qm74 996 27 cell cell NN cord-015021-pol2qm74 996 28 signal signal NN cord-015021-pol2qm74 996 29 transductive transductive NNP cord-015021-pol2qm74 996 30 capacity capacity NN cord-015021-pol2qm74 996 31 while while IN cord-015021-pol2qm74 996 32 reducing reduce VBG cord-015021-pol2qm74 996 33 the the DT cord-015021-pol2qm74 996 34 levels level NNS cord-015021-pol2qm74 996 35 of of IN cord-015021-pol2qm74 996 36 cAMP camp NN cord-015021-pol2qm74 996 37 . . . cord-015021-pol2qm74 997 1 Nonetheless nonetheless RB cord-015021-pol2qm74 997 2 , , , cord-015021-pol2qm74 997 3 the the DT cord-015021-pol2qm74 997 4 extent extent NN cord-015021-pol2qm74 997 5 to to TO cord-015021-pol2qm74 997 6 which which WDT cord-015021-pol2qm74 997 7 depressed depressed JJ cord-015021-pol2qm74 997 8 receptor receptor NN cord-015021-pol2qm74 997 9 signal signal NN cord-015021-pol2qm74 997 10 transduction transduction NN cord-015021-pol2qm74 997 11 in in IN cord-015021-pol2qm74 997 12 HEM HEM NNP cord-015021-pol2qm74 997 13 , , , cord-015021-pol2qm74 997 14 is be VBZ cord-015021-pol2qm74 997 15 due due JJ cord-015021-pol2qm74 997 16 to to IN cord-015021-pol2qm74 997 17 receptor receptor NN cord-015021-pol2qm74 997 18 loss loss NN cord-015021-pol2qm74 997 19 ~ ~ NFP cord-015021-pol2qm74 997 20 dysfunction dysfunction NN cord-015021-pol2qm74 997 21 or or CC cord-015021-pol2qm74 997 22 elevated elevate VBN cord-015021-pol2qm74 997 23 antagonistic antagonistic JJ cord-015021-pol2qm74 997 24 second second JJ cord-015021-pol2qm74 997 25 messenger messenger NN cord-015021-pol2qm74 997 26 levels level NNS cord-015021-pol2qm74 997 27 remains remain VBZ cord-015021-pol2qm74 997 28 to to TO cord-015021-pol2qm74 997 29 be be VB cord-015021-pol2qm74 997 30 determined determine VBN cord-015021-pol2qm74 997 31 . . . cord-015021-pol2qm74 998 1 Conclusions conclusion NNS cord-015021-pol2qm74 998 2 : : : cord-015021-pol2qm74 999 1 Significant significant JJ cord-015021-pol2qm74 999 2 impairment impairment NN cord-015021-pol2qm74 999 3 of of IN cord-015021-pol2qm74 999 4 calcium calcium NN cord-015021-pol2qm74 999 5 signaling signaling NN cord-015021-pol2qm74 999 6 occurs occur VBZ cord-015021-pol2qm74 999 7 at at IN cord-015021-pol2qm74 999 8 all all DT cord-015021-pol2qm74 999 9 time time NN cord-015021-pol2qm74 999 10 - - HYPH cord-015021-pol2qm74 999 11 points point NNS cord-015021-pol2qm74 999 12 prior prior RB cord-015021-pol2qm74 999 13 to to IN cord-015021-pol2qm74 999 14 and and CC cord-015021-pol2qm74 999 15 following follow VBG cord-015021-pol2qm74 999 16 PHA PHA NNP cord-015021-pol2qm74 999 17 stimulation stimulation NN cord-015021-pol2qm74 999 18 in in IN cord-015021-pol2qm74 999 19 trauma trauma NN cord-015021-pol2qm74 999 20 patients patient NNS cord-015021-pol2qm74 999 21 . . . cord-015021-pol2qm74 1000 1 Tcell Tcell NNP cord-015021-pol2qm74 1000 2 activation activation NN cord-015021-pol2qm74 1000 3 failure failure NN cord-015021-pol2qm74 1000 4 can can MD cord-015021-pol2qm74 1000 5 , , , cord-015021-pol2qm74 1000 6 in in IN cord-015021-pol2qm74 1000 7 part part NN cord-015021-pol2qm74 1000 8 , , , cord-015021-pol2qm74 1000 9 be be VB cord-015021-pol2qm74 1000 10 explained explain VBN cord-015021-pol2qm74 1000 11 by by IN cord-015021-pol2qm74 1000 12 the the DT cord-015021-pol2qm74 1000 13 inadequacy inadequacy NN cord-015021-pol2qm74 1000 14 of of IN cord-015021-pol2qm74 1000 15 this this DT cord-015021-pol2qm74 1000 16 essential essential JJ cord-015021-pol2qm74 1000 17 intracellular intracellular JJ cord-015021-pol2qm74 1000 18 second second JJ cord-015021-pol2qm74 1000 19 messenger messenger NN cord-015021-pol2qm74 1000 20 system system NN cord-015021-pol2qm74 1000 21 . . . cord-015021-pol2qm74 1001 1 Restoration restoration NN cord-015021-pol2qm74 1001 2 of of IN cord-015021-pol2qm74 1001 3 immunocompetence immunocompetence NN cord-015021-pol2qm74 1001 4 following follow VBG cord-015021-pol2qm74 1001 5 trauma trauma NN cord-015021-pol2qm74 1001 6 will will MD cord-015021-pol2qm74 1001 7 have have VB cord-015021-pol2qm74 1001 8 to to TO cord-015021-pol2qm74 1001 9 address address VB cord-015021-pol2qm74 1001 10 strategies strategy NNS cord-015021-pol2qm74 1001 11 to to TO cord-015021-pol2qm74 1001 12 better better RB cord-015021-pol2qm74 1001 13 assess assess VB cord-015021-pol2qm74 1001 14 and and CC cord-015021-pol2qm74 1001 15 restore restore VB cord-015021-pol2qm74 1001 16 this this DT cord-015021-pol2qm74 1001 17 vital vital JJ cord-015021-pol2qm74 1001 18 step step NN cord-015021-pol2qm74 1001 19 in in IN cord-015021-pol2qm74 1001 20 the the DT cord-015021-pol2qm74 1001 21 activation activation NN cord-015021-pol2qm74 1001 22 sequence sequence NN cord-015021-pol2qm74 1001 23 leading lead VBG cord-015021-pol2qm74 1001 24 to to IN cord-015021-pol2qm74 1001 25 proliferation proliferation NN cord-015021-pol2qm74 1001 26 during during IN cord-015021-pol2qm74 1001 27 the the DT cord-015021-pol2qm74 1001 28 antigen antigen NN cord-015021-pol2qm74 1001 29 recognition recognition NN cord-015021-pol2qm74 1001 30 process process NN cord-015021-pol2qm74 1001 31 . . . cord-015021-pol2qm74 1002 1 Patrick Patrick NNP cord-015021-pol2qm74 1002 2 A. a. NN cord-015021-pol2qm74 1002 3 Bseuerle Bseuerle NNP cord-015021-pol2qm74 1002 4 Institute Institute NNP cord-015021-pol2qm74 1002 5 01 01 CD cord-015021-pol2qm74 1002 6 Biochemistry Biochemistry NNP cord-015021-pol2qm74 1002 7 , , , cord-015021-pol2qm74 1002 8 Albert Albert NNP cord-015021-pol2qm74 1002 9 - - HYPH cord-015021-pol2qm74 1002 10 Ludwigs Ludwigs NNP cord-015021-pol2qm74 1002 11 - - HYPH cord-015021-pol2qm74 1002 12 University University NNP cord-015021-pol2qm74 1002 13 , , , cord-015021-pol2qm74 1002 14 Hermann Hermann NNP cord-015021-pol2qm74 1002 15 - - HYPH cord-015021-pol2qm74 1002 16 Herder Herder NNP cord-015021-pol2qm74 1002 17 - - HYPH cord-015021-pol2qm74 1002 18 Str Str NNP cord-015021-pol2qm74 1002 19 . . NNP cord-015021-pol2qm74 1002 20 7 7 CD cord-015021-pol2qm74 1002 21 , , , cord-015021-pol2qm74 1002 22 D-79104 D-79104 NNP cord-015021-pol2qm74 1002 23 Freiburg Freiburg NNP cord-015021-pol2qm74 1002 24 , , , cord-015021-pol2qm74 1002 25 Germany Germany NNP cord-015021-pol2qm74 1003 1 The the DT cord-015021-pol2qm74 1003 2 active active JJ cord-015021-pol2qm74 1003 3 form form NN cord-015021-pol2qm74 1003 4 of of IN cord-015021-pol2qm74 1003 5 the the DT cord-015021-pol2qm74 1003 6 transcriptional transcriptional JJ cord-015021-pol2qm74 1003 7 activator activator NN cord-015021-pol2qm74 1003 8 NF-~B NF-~B NNP cord-015021-pol2qm74 1003 9 is be VBZ cord-015021-pol2qm74 1003 10 a a DT cord-015021-pol2qm74 1003 11 heteredimer heteredimer NN cord-015021-pol2qm74 1003 12 composed compose VBN cord-015021-pol2qm74 1003 13 of of IN cord-015021-pol2qm74 1003 14 a a DT cord-015021-pol2qm74 1003 15 50 50 CD cord-015021-pol2qm74 1003 16 and and CC cord-015021-pol2qm74 1003 17 65 65 CD cord-015021-pol2qm74 1003 18 kDa kDa NNP cord-015021-pol2qm74 1003 19 polypeptide polypeptide NN cord-015021-pol2qm74 1003 20 . . . cord-015021-pol2qm74 1004 1 In in IN cord-015021-pol2qm74 1004 2 this this DT cord-015021-pol2qm74 1004 3 form form NN cord-015021-pol2qm74 1004 4 , , , cord-015021-pol2qm74 1004 5 NF-'Lewis Lewis->Lewis NNP cord-015021-pol2qm74 1132 5 ) ) -RRB- cord-015021-pol2qm74 1132 6 were be VBD cord-015021-pol2qm74 1132 7 were be VBD cord-015021-pol2qm74 1132 8 divided divide VBN cord-015021-pol2qm74 1132 9 into into IN cord-015021-pol2qm74 1132 10 ischemic ischemic JJ cord-015021-pol2qm74 1132 11 and and CC cord-015021-pol2qm74 1132 12 non non JJ cord-015021-pol2qm74 1132 13 - - JJ cord-015021-pol2qm74 1132 14 ischemic ischemic JJ cord-015021-pol2qm74 1132 15 groups group NNS cord-015021-pol2qm74 1132 16 ( ( -LRB- cord-015021-pol2qm74 1132 17 n=30 n=30 NNP cord-015021-pol2qm74 1132 18 / / SYM cord-015021-pol2qm74 1132 19 group group NN cord-015021-pol2qm74 1132 20 ) ) -RRB- cord-015021-pol2qm74 1132 21 . . . cord-015021-pol2qm74 1133 1 All all DT cord-015021-pol2qm74 1133 2 donor donor NN cord-015021-pol2qm74 1133 3 hearts heart NNS cord-015021-pol2qm74 1133 4 were be VBD cord-015021-pol2qm74 1133 5 flushed flush VBN cord-015021-pol2qm74 1133 6 immediately immediately RB cord-015021-pol2qm74 1133 7 with with IN cord-015021-pol2qm74 1133 8 cold cold JJ cord-015021-pol2qm74 1133 9 saline saline NN cord-015021-pol2qm74 1133 10 . . . cord-015021-pol2qm74 1134 1 Non non JJ cord-015021-pol2qm74 1134 2 - - JJ cord-015021-pol2qm74 1134 3 ischemic ischemic JJ cord-015021-pol2qm74 1134 4 hearts heart NNS cord-015021-pol2qm74 1134 5 were be VBD cord-015021-pol2qm74 1134 6 then then RB cord-015021-pol2qm74 1134 7 transplanted transplant VBN cord-015021-pol2qm74 1134 8 within within IN cord-015021-pol2qm74 1134 9 30 30 CD cord-015021-pol2qm74 1134 10 rain rain NN cord-015021-pol2qm74 1134 11 , , , cord-015021-pol2qm74 1134 12 ischemic ischemic JJ cord-015021-pol2qm74 1134 13 hearts heart NNS cord-015021-pol2qm74 1134 14 were be VBD cord-015021-pol2qm74 1134 15 stored store VBN cord-015021-pol2qm74 1134 16 in in IN cord-015021-pol2qm74 1134 17 cold cold JJ cord-015021-pol2qm74 1134 18 Ringer Ringer NNP cord-015021-pol2qm74 1134 19 's 's POS cord-015021-pol2qm74 1134 20 solution solution NN cord-015021-pol2qm74 1134 21 for for IN cord-015021-pol2qm74 1134 22 3 3 CD cord-015021-pol2qm74 1134 23 hours hour NNS cord-015021-pol2qm74 1134 24 before before IN cord-015021-pol2qm74 1134 25 revascularization revascularization NN cord-015021-pol2qm74 1134 26 . . . cord-015021-pol2qm74 1135 1 Representative representative JJ cord-015021-pol2qm74 1135 2 grafts graft NNS cord-015021-pol2qm74 1135 3 were be VBD cord-015021-pol2qm74 1135 4 removed remove VBN cord-015021-pol2qm74 1135 5 after after IN cord-015021-pol2qm74 1135 6 12 12 CD cord-015021-pol2qm74 1135 7 . . . cord-015021-pol2qm74 1136 1 24 24 CD cord-015021-pol2qm74 1136 2 , , , cord-015021-pol2qm74 1136 3 72hrs 72hrs NN cord-015021-pol2qm74 1136 4 , , , cord-015021-pol2qm74 1136 5 10 10 CD cord-015021-pol2qm74 1136 6 and and CC cord-015021-pol2qm74 1136 7 100 100 CD cord-015021-pol2qm74 1136 8 days day NNS cord-015021-pol2qm74 1136 9 , , , cord-015021-pol2qm74 1136 10 and and CC cord-015021-pol2qm74 1136 11 evaluated evaluate VBN cord-015021-pol2qm74 1136 12 immunohistologically immunohistologically RB cord-015021-pol2qm74 1136 13 ( ( -LRB- cord-015021-pol2qm74 1136 14 cells cell NNS cord-015021-pol2qm74 1136 15 / / SYM cord-015021-pol2qm74 1136 16 field field NN cord-015021-pol2qm74 1136 17 of of IN cord-015021-pol2qm74 1136 18 view view NN cord-015021-pol2qm74 1136 19 = = SYM cord-015021-pol2qm74 1136 20 C c NN cord-015021-pol2qm74 1136 21 / / SYM cord-015021-pol2qm74 1136 22 F F NNP cord-015021-pol2qm74 1136 23 ) ) -RRB- cord-015021-pol2qm74 1136 24 . . . cord-015021-pol2qm74 1137 1 Restitution restitution NN cord-015021-pol2qm74 1137 2 of of IN cord-015021-pol2qm74 1137 3 ventricular ventricular JJ cord-015021-pol2qm74 1137 4 activity activity NN cord-015021-pol2qm74 1137 5 was be VBD cord-015021-pol2qm74 1137 6 significantly significantly RB cord-015021-pol2qm74 1137 7 delayed delay VBN cord-015021-pol2qm74 1137 8 in in IN cord-015021-pol2qm74 1137 9 ischemic ischemic JJ cord-015021-pol2qm74 1137 10 grafts graft NNS cord-015021-pol2qm74 1137 11 ( ( -LRB- cord-015021-pol2qm74 1137 12 5 5 CD cord-015021-pol2qm74 1137 13 vs vs IN cord-015021-pol2qm74 1137 14 1 1 CD cord-015021-pol2qm74 1137 15 rain rain NN cord-015021-pol2qm74 1137 16 ) ) -RRB- cord-015021-pol2qm74 1137 17 . . . cord-015021-pol2qm74 1138 1 After after IN cord-015021-pol2qm74 1138 2 12 12 CD cord-015021-pol2qm74 1138 3 hrs hrs NN cord-015021-pol2qm74 1138 4 , , , cord-015021-pol2qm74 1138 5 all all DT cord-015021-pol2qm74 1138 6 ischemic ischemic JJ cord-015021-pol2qm74 1138 7 grafts graft NNS cord-015021-pol2qm74 1138 8 exhibited exhibit VBD cord-015021-pol2qm74 1138 9 an an DT cord-015021-pol2qm74 1138 10 extensive extensive JJ cord-015021-pol2qm74 1138 11 interstitial interstitial JJ cord-015021-pol2qm74 1138 12 edema edema NN cord-015021-pol2qm74 1138 13 , , , cord-015021-pol2qm74 1138 14 declining decline VBG cord-015021-pol2qm74 1138 15 slowly slowly RB cord-015021-pol2qm74 1138 16 thereafter thereafter RB cord-015021-pol2qm74 1138 17 . . . cord-015021-pol2qm74 1139 1 At at IN cord-015021-pol2qm74 1139 2 the the DT cord-015021-pol2qm74 1139 3 same same JJ cord-015021-pol2qm74 1139 4 time time NN cord-015021-pol2qm74 1139 5 , , , cord-015021-pol2qm74 1139 6 numbers number NNS cord-015021-pol2qm74 1139 7 of of IN cord-015021-pol2qm74 1139 8 PMN PMN NNP cord-015021-pol2qm74 1139 9 peaked peak VBD cord-015021-pol2qm74 1139 10 ( ( -LRB- cord-015021-pol2qm74 1139 11 3 3 CD cord-015021-pol2qm74 1139 12 vs vs IN cord-015021-pol2qm74 1139 13 1 1 CD cord-015021-pol2qm74 1139 14 C C NNP cord-015021-pol2qm74 1139 15 / / SYM cord-015021-pol2qm74 1139 16 F F NNP cord-015021-pol2qm74 1139 17 in in IN cord-015021-pol2qm74 1139 18 non non JJ cord-015021-pol2qm74 1139 19 - - JJ cord-015021-pol2qm74 1139 20 ischemic ischemic JJ cord-015021-pol2qm74 1139 21 grafts graft NNS cord-015021-pol2qm74 1139 22 ) ) -RRB- cord-015021-pol2qm74 1139 23 , , , cord-015021-pol2qm74 1139 24 whereas whereas IN cord-015021-pol2qm74 1139 25 EDl+macrophages edl+macrophage NNS cord-015021-pol2qm74 1139 26 ( ( -LRB- cord-015021-pol2qm74 1139 27 9 9 CD cord-015021-pol2qm74 1139 28 vs vs IN cord-015021-pol2qm74 1139 29 2 2 CD cord-015021-pol2qm74 1139 30 C C NNP cord-015021-pol2qm74 1139 31 / / SYM cord-015021-pol2qm74 1139 32 F F NNP cord-015021-pol2qm74 1139 33 ) ) -RRB- cord-015021-pol2qm74 1139 34 and and CC cord-015021-pol2qm74 1139 35 TNFe TNFe NNP cord-015021-pol2qm74 1139 36 expression expression NN cord-015021-pol2qm74 1139 37 peaked peak VBD cord-015021-pol2qm74 1139 38 by by IN cord-015021-pol2qm74 1139 39 24hrs 24hrs NN cord-015021-pol2qm74 1139 40 . . . cord-015021-pol2qm74 1140 1 By by IN cord-015021-pol2qm74 1140 2 72 72 CD cord-015021-pol2qm74 1140 3 hrs hrs NN cord-015021-pol2qm74 1140 4 T t NN cord-015021-pol2qm74 1140 5 - - HYPH cord-015021-pol2qm74 1140 6 lymphocytes lymphocyte NNS cord-015021-pol2qm74 1140 7 began begin VBD cord-015021-pol2qm74 1140 8 to to TO cord-015021-pol2qm74 1140 9 enter enter VB cord-015021-pol2qm74 1140 10 ischemic ischemic JJ cord-015021-pol2qm74 1140 11 myocardium myocardium NN cord-015021-pol2qm74 1140 12 and and CC cord-015021-pol2qm74 1140 13 ICAM-1 icam-1 NN cord-015021-pol2qm74 1140 14 was be VBD cord-015021-pol2qm74 1140 15 moderately moderately RB cord-015021-pol2qm74 1140 16 increased increase VBN cord-015021-pol2qm74 1140 17 . . . cord-015021-pol2qm74 1141 1 After after IN cord-015021-pol2qm74 1141 2 10 10 CD cord-015021-pol2qm74 1141 3 days day NNS cord-015021-pol2qm74 1141 4 cellular cellular JJ cord-015021-pol2qm74 1141 5 infiltration infiltration NN cord-015021-pol2qm74 1141 6 had have VBD cord-015021-pol2qm74 1141 7 returned return VBN cord-015021-pol2qm74 1141 8 to to IN cord-015021-pol2qm74 1141 9 baseline baseline NN cord-015021-pol2qm74 1141 10 , , , cord-015021-pol2qm74 1141 11 and and CC cord-015021-pol2qm74 1141 12 no no DT cord-015021-pol2qm74 1141 13 differences difference NNS cord-015021-pol2qm74 1141 14 were be VBD cord-015021-pol2qm74 1141 15 seen see VBN cord-015021-pol2qm74 1141 16 among among IN cord-015021-pol2qm74 1141 17 both both DT cord-015021-pol2qm74 1141 18 groups group NNS cord-015021-pol2qm74 1141 19 after after IN cord-015021-pol2qm74 1141 20 100 100 CD cord-015021-pol2qm74 1141 21 days day NNS cord-015021-pol2qm74 1141 22 . . . cord-015021-pol2qm74 1142 1 Global global JJ cord-015021-pol2qm74 1142 2 myocardial myocardial JJ cord-015021-pol2qm74 1142 3 ischemia ischemia NN cord-015021-pol2qm74 1142 4 inhibits inhibit VBZ cord-015021-pol2qm74 1142 5 initial initial JJ cord-015021-pol2qm74 1142 6 graft graft NN cord-015021-pol2qm74 1142 7 function function NN cord-015021-pol2qm74 1142 8 , , , cord-015021-pol2qm74 1142 9 and and CC cord-015021-pol2qm74 1142 10 engenders engender VBZ cord-015021-pol2qm74 1142 11 a a DT cord-015021-pol2qm74 1142 12 brisk brisk JJ cord-015021-pol2qm74 1142 13 inflammatory inflammatory JJ cord-015021-pol2qm74 1142 14 reponse reponse NN cord-015021-pol2qm74 1142 15 , , , cord-015021-pol2qm74 1142 16 primarily primarily RB cord-015021-pol2qm74 1142 17 PMN PMN NNP cord-015021-pol2qm74 1142 18 and and CC cord-015021-pol2qm74 1142 19 macrophages macrophage NNS cord-015021-pol2qm74 1142 20 , , , cord-015021-pol2qm74 1142 21 with with IN cord-015021-pol2qm74 1142 22 increased increase VBN cord-015021-pol2qm74 1142 23 MHC MHC NNP cord-015021-pol2qm74 1142 24 Class Class NNP cord-015021-pol2qm74 1142 25 II II NNP cord-015021-pol2qm74 1142 26 and and CC cord-015021-pol2qm74 1142 27 cytokine cytokine JJ cord-015021-pol2qm74 1142 28 expression expression NN cord-015021-pol2qm74 1142 29 . . . cord-015021-pol2qm74 1143 1 Leukocyte Leukocyte NNP cord-015021-pol2qm74 1143 2 -endothelial -endothelial . cord-015021-pol2qm74 1144 1 interactions interaction NNS cord-015021-pol2qm74 1144 2 are be VBP cord-015021-pol2qm74 1144 3 the the DT cord-015021-pol2qm74 1144 4 result result NN cord-015021-pol2qm74 1144 5 of of IN cord-015021-pol2qm74 1144 6 endothelial endothelial JJ cord-015021-pol2qm74 1144 7 activation activation NN cord-015021-pol2qm74 1144 8 , , , cord-015021-pol2qm74 1144 9 leukocyte leukocyte NN cord-015021-pol2qm74 1144 10 activation activation NN cord-015021-pol2qm74 1144 11 or or CC cord-015021-pol2qm74 1144 12 combination combination NN cord-015021-pol2qm74 1144 13 of of IN cord-015021-pol2qm74 1144 14 both both DT cord-015021-pol2qm74 1144 15 , , , cord-015021-pol2qm74 1144 16 which which WDT cord-015021-pol2qm74 1144 17 are be VBP cord-015021-pol2qm74 1144 18 accompanied accompany VBN cord-015021-pol2qm74 1144 19 by by IN cord-015021-pol2qm74 1144 20 nee nee NN cord-015021-pol2qm74 1144 21 - - HYPH cord-015021-pol2qm74 1144 22 expression expression NN cord-015021-pol2qm74 1144 23 , , , cord-015021-pol2qm74 1144 24 upregulation upregulation NN cord-015021-pol2qm74 1144 25 or or CC cord-015021-pol2qm74 1144 26 shedding shedding NN cord-015021-pol2qm74 1144 27 of of IN cord-015021-pol2qm74 1144 28 adhesion adhesion NN cord-015021-pol2qm74 1144 29 molecules molecule NNS cord-015021-pol2qm74 1144 30 ( ( -LRB- cord-015021-pol2qm74 1144 31 Selectins Selectins NNPS cord-015021-pol2qm74 1144 32 , , , cord-015021-pol2qm74 1144 33 Inlegrins Inlegrins NNP cord-015021-pol2qm74 1144 34 ) ) -RRB- cord-015021-pol2qm74 1144 35 . . . cord-015021-pol2qm74 1145 1 Such such JJ cord-015021-pol2qm74 1145 2 interactions interaction NNS cord-015021-pol2qm74 1145 3 differ differ VBP cord-015021-pol2qm74 1145 4 with with IN cord-015021-pol2qm74 1145 5 regard regard NN cord-015021-pol2qm74 1145 6 to to IN cord-015021-pol2qm74 1145 7 the the DT cord-015021-pol2qm74 1145 8 stimulus stimulus NN cord-015021-pol2qm74 1145 9 ( ( -LRB- cord-015021-pol2qm74 1145 10 e.g. e.g. IN cord-015021-pol2qm74 1145 11 thrombin thrombin NN cord-015021-pol2qm74 1145 12 or or CC cord-015021-pol2qm74 1145 13 histamine histamine NN cord-015021-pol2qm74 1145 14 for for IN cord-015021-pol2qm74 1145 15 P p NN cord-015021-pol2qm74 1145 16 - - HYPH cord-015021-pol2qm74 1145 17 selectin selectin NN cord-015021-pol2qm74 1145 18 , , , cord-015021-pol2qm74 1145 19 endotoxin endotoxin NN cord-015021-pol2qm74 1145 20 or or CC cord-015021-pol2qm74 1145 21 TNF TNF NNP cord-015021-pol2qm74 1145 22 / / SYM cord-015021-pol2qm74 1145 23 IL-1 IL-1 NNP cord-015021-pol2qm74 1145 24 for for IN cord-015021-pol2qm74 1145 25 E E NNP cord-015021-pol2qm74 1145 26 - - NN cord-015021-pol2qm74 1145 27 selectin selectin NNP cord-015021-pol2qm74 1145 28 ) ) -RRB- cord-015021-pol2qm74 1145 29 , , , cord-015021-pol2qm74 1145 30 the the DT cord-015021-pol2qm74 1145 31 time time NN cord-015021-pol2qm74 1145 32 course course NN cord-015021-pol2qm74 1145 33 of of IN cord-015021-pol2qm74 1145 34 response response NN cord-015021-pol2qm74 1145 35 ( ( -LRB- cord-015021-pol2qm74 1145 36 minutes minute NNS cord-015021-pol2qm74 1145 37 versus versus IN cord-015021-pol2qm74 1145 38 hours hour NNS cord-015021-pol2qm74 1145 39 ) ) -RRB- cord-015021-pol2qm74 1145 40 and and CC cord-015021-pol2qm74 1145 41 the the DT cord-015021-pol2qm74 1145 42 localisation localisation NN cord-015021-pol2qm74 1145 43 in in IN cord-015021-pol2qm74 1145 44 different different JJ cord-015021-pol2qm74 1145 45 organs organ NNS cord-015021-pol2qm74 1145 46 . . . cord-015021-pol2qm74 1146 1 Recently recently RB cord-015021-pol2qm74 1146 2 assays assay NNS cord-015021-pol2qm74 1146 3 are be VBP cord-015021-pol2qm74 1146 4 available available JJ cord-015021-pol2qm74 1146 5 for for IN cord-015021-pol2qm74 1146 6 circulating circulate VBG cord-015021-pol2qm74 1146 7 soluble soluble JJ cord-015021-pol2qm74 1146 8 fragments fragment NNS cord-015021-pol2qm74 1146 9 of of IN cord-015021-pol2qm74 1146 10 the the DT cord-015021-pol2qm74 1146 11 cell cell NN cord-015021-pol2qm74 1146 12 bound bind VBN cord-015021-pol2qm74 1146 13 adhesion adhesion NN cord-015021-pol2qm74 1146 14 molecules molecule NNS cord-015021-pol2qm74 1146 15 e.g. e.g. RB cord-015021-pol2qm74 1146 16 sE sE NNP cord-015021-pol2qm74 1146 17 - - HYPH cord-015021-pol2qm74 1146 18 seleetin seleetin NNP cord-015021-pol2qm74 1146 19 was be VBD cord-015021-pol2qm74 1146 20 found find VBN cord-015021-pol2qm74 1146 21 to to TO cord-015021-pol2qm74 1146 22 be be VB cord-015021-pol2qm74 1146 23 increased increase VBN cord-015021-pol2qm74 1146 24 in in IN cord-015021-pol2qm74 1146 25 plasma plasma NN cord-015021-pol2qm74 1146 26 concurrent concurrent JJ cord-015021-pol2qm74 1146 27 with with IN cord-015021-pol2qm74 1146 28 high high JJ cord-015021-pol2qm74 1146 29 circulating circulate VBG cord-015021-pol2qm74 1146 30 endoloxin endoloxin NN cord-015021-pol2qm74 1146 31 and and CC cord-015021-pol2qm74 1146 32 cytokine cytokine NN cord-015021-pol2qm74 1146 33 levels level NNS cord-015021-pol2qm74 1146 34 . . . cord-015021-pol2qm74 1147 1 The the DT cord-015021-pol2qm74 1147 2 importance importance NN cord-015021-pol2qm74 1147 3 of of IN cord-015021-pol2qm74 1147 4 adhesion adhesion NN cord-015021-pol2qm74 1147 5 molecules molecule NNS cord-015021-pol2qm74 1147 6 for for IN cord-015021-pol2qm74 1147 7 the the DT cord-015021-pol2qm74 1147 8 sepsis sepsis NN cord-015021-pol2qm74 1147 9 event event NN cord-015021-pol2qm74 1147 10 is be VBZ cord-015021-pol2qm74 1147 11 evident evident JJ cord-015021-pol2qm74 1147 12 , , , cord-015021-pol2qm74 1147 13 while while IN cord-015021-pol2qm74 1147 14 effectiveness effectiveness NN cord-015021-pol2qm74 1147 15 of of IN cord-015021-pol2qm74 1147 16 anti anti JJ cord-015021-pol2qm74 1147 17 - - JJ cord-015021-pol2qm74 1147 18 adhesion adhesion JJ cord-015021-pol2qm74 1147 19 inolecu]e inolecu]e NN cord-015021-pol2qm74 1147 20 therapy therapy NN cord-015021-pol2qm74 1147 21 is be VBZ cord-015021-pol2qm74 1147 22 controversial controversial JJ cord-015021-pol2qm74 1147 23 e.g. e.g. IN cord-015021-pol2qm74 1147 24 beneficial beneficial JJ cord-015021-pol2qm74 1147 25 anti anti JJ cord-015021-pol2qm74 1147 26 - - JJ cord-015021-pol2qm74 1147 27 E e JJ cord-015021-pol2qm74 1147 28 - - HYPH cord-015021-pol2qm74 1147 29 selectin selectin JJ cord-015021-pol2qm74 1147 30 therapy therapy NN cord-015021-pol2qm74 1147 31 in in IN cord-015021-pol2qm74 1147 32 baboon baboon NN cord-015021-pol2qm74 1147 33 bacleremia bacleremia NNP cord-015021-pol2qm74 1147 34 but but CC cord-015021-pol2qm74 1147 35 deleterious deleterious JJ cord-015021-pol2qm74 1147 36 effects effect NNS cord-015021-pol2qm74 1147 37 of of IN cord-015021-pol2qm74 1147 38 amti amti JJ cord-015021-pol2qm74 1147 39 - - HYPH cord-015021-pol2qm74 1147 40 CD18 CD18 NNP cord-015021-pol2qm74 1147 41 treatment treatment NN cord-015021-pol2qm74 1147 42 in in IN cord-015021-pol2qm74 1147 43 the the DT cord-015021-pol2qm74 1147 44 same same JJ cord-015021-pol2qm74 1147 45 model model NN cord-015021-pol2qm74 1147 46 . . . cord-015021-pol2qm74 1148 1 In in IN cord-015021-pol2qm74 1148 2 other other JJ cord-015021-pol2qm74 1148 3 species specie NNS cord-015021-pol2qm74 1148 4 similar similar JJ cord-015021-pol2qm74 1148 5 controversial controversial JJ cord-015021-pol2qm74 1148 6 results result NNS cord-015021-pol2qm74 1148 7 with with IN cord-015021-pol2qm74 1148 8 anti anti JJ cord-015021-pol2qm74 1148 9 - - JJ cord-015021-pol2qm74 1148 10 CD18 cd18 JJ cord-015021-pol2qm74 1148 11 therapy therapy NN cord-015021-pol2qm74 1148 12 in in IN cord-015021-pol2qm74 1148 13 sepsis sepsis NN cord-015021-pol2qm74 1148 14 were be VBD cord-015021-pol2qm74 1148 15 reported report VBN cord-015021-pol2qm74 1148 16 . . . cord-015021-pol2qm74 1149 1 Steven Steven NNP cord-015021-pol2qm74 1149 2 L. L. NNP cord-015021-pol2qm74 1149 3 Kunkel Kunkel NNP cord-015021-pol2qm74 1149 4 , , , cord-015021-pol2qm74 1149 5 Theodore Theodore NNP cord-015021-pol2qm74 1149 6 Standiford Standiford NNP cord-015021-pol2qm74 1149 7 * * NFP cord-015021-pol2qm74 1149 8 and and CC cord-015021-pol2qm74 1149 9 Robert Robert NNP cord-015021-pol2qm74 1149 10 M. M. NNP cord-015021-pol2qm74 1149 11 Stricter Stricter NNP cord-015021-pol2qm74 1149 12 . . . cord-015021-pol2qm74 1150 1 The the DT cord-015021-pol2qm74 1150 2 migration migration NN cord-015021-pol2qm74 1150 3 of of IN cord-015021-pol2qm74 1150 4 leukocytes leukocyte NNS cord-015021-pol2qm74 1150 5 to to IN cord-015021-pol2qm74 1150 6 the the DT cord-015021-pol2qm74 1150 7 lung lung NN cord-015021-pol2qm74 1150 8 during during IN cord-015021-pol2qm74 1150 9 endotoxemia endotoxemia NN cord-015021-pol2qm74 1150 10 is be VBZ cord-015021-pol2qm74 1150 11 dependent dependent JJ cord-015021-pol2qm74 1150 12 upon upon IN cord-015021-pol2qm74 1150 13 the the DT cord-015021-pol2qm74 1150 14 coordinated coordinated JJ cord-015021-pol2qm74 1150 15 expression expression NN cord-015021-pol2qm74 1150 16 of of IN cord-015021-pol2qm74 1150 17 lung lung NN cord-015021-pol2qm74 1150 18 vascular vascular JJ cord-015021-pol2qm74 1150 19 adhesion adhesion NN cord-015021-pol2qm74 1150 20 molecules molecule NNS cord-015021-pol2qm74 1150 21 and and CC cord-015021-pol2qm74 1150 22 the the DT cord-015021-pol2qm74 1150 23 subsequent subsequent JJ cord-015021-pol2qm74 1150 24 production production NN cord-015021-pol2qm74 1150 25 of of IN cord-015021-pol2qm74 1150 26 appropriate appropriate JJ cord-015021-pol2qm74 1150 27 leukocyte leukocyte NN cord-015021-pol2qm74 1150 28 chemotactic chemotactic VBN cord-015021-pol2qm74 1150 29 proteins protein NNS cord-015021-pol2qm74 1150 30 . . . cord-015021-pol2qm74 1151 1 In in IN cord-015021-pol2qm74 1151 2 experimental experimental JJ cord-015021-pol2qm74 1151 3 animals animal NNS cord-015021-pol2qm74 1151 4 , , , cord-015021-pol2qm74 1151 5 neutrophils neutrophil NNS cord-015021-pol2qm74 1151 6 accumulate accumulate VBP cord-015021-pol2qm74 1151 7 within within IN cord-015021-pol2qm74 1151 8 the the DT cord-015021-pol2qm74 1151 9 lung lung NN cord-015021-pol2qm74 1151 10 soon soon RB cord-015021-pol2qm74 1151 11 after after IN cord-015021-pol2qm74 1151 12 the the DT cord-015021-pol2qm74 1151 13 administration administration NN cord-015021-pol2qm74 1151 14 of of IN cord-015021-pol2qm74 1151 15 endotoxin endotoxin NN cord-015021-pol2qm74 1151 16 , , , cord-015021-pol2qm74 1151 17 while while IN cord-015021-pol2qm74 1151 18 mononuclear mononuclear JJ cord-015021-pol2qm74 1151 19 cell cell NN cord-015021-pol2qm74 1151 20 infiltration infiltration NN cord-015021-pol2qm74 1151 21 occurs occur VBZ cord-015021-pol2qm74 1151 22 in in IN cord-015021-pol2qm74 1151 23 a a DT cord-015021-pol2qm74 1151 24 more more RBR cord-015021-pol2qm74 1151 25 distal distal JJ cord-015021-pol2qm74 1151 26 manner manner NN cord-015021-pol2qm74 1151 27 . . . cord-015021-pol2qm74 1152 1 A a DT cord-015021-pol2qm74 1152 2 kinetic kinetic JJ cord-015021-pol2qm74 1152 3 analysis analysis NN cord-015021-pol2qm74 1152 4 of of IN cord-015021-pol2qm74 1152 5 lung lung NN cord-015021-pol2qm74 1152 6 leukocyte leukocyte NN cord-015021-pol2qm74 1152 7 levels level NNS cord-015021-pol2qm74 1152 8 revealed reveal VBD cord-015021-pol2qm74 1152 9 a a DT cord-015021-pol2qm74 1152 10 3-fold 3-fold CD cord-015021-pol2qm74 1152 11 increase increase NN cord-015021-pol2qm74 1152 12 in in IN cord-015021-pol2qm74 1152 13 neutrophil neutrophil NN cord-015021-pol2qm74 1152 14 numbers number NNS cord-015021-pol2qm74 1152 15 associated associate VBN cord-015021-pol2qm74 1152 16 with with IN cord-015021-pol2qm74 1152 17 dispersed disperse VBN cord-015021-pol2qm74 1152 18 lullg lullg JJ cord-015021-pol2qm74 1152 19 tissues tissue NNS cord-015021-pol2qm74 1152 20 2 2 CD cord-015021-pol2qm74 1152 21 hours hour NNS cord-015021-pol2qm74 1152 22 after after IN cord-015021-pol2qm74 1152 23 LPS LPS NNP cord-015021-pol2qm74 1152 24 treatment treatment NN cord-015021-pol2qm74 1152 25 , , , cord-015021-pol2qm74 1152 26 while while IN cord-015021-pol2qm74 1152 27 macrophage macrophage NN cord-015021-pol2qm74 1152 28 levels level NNS cord-015021-pol2qm74 1152 29 increased increase VBN cord-015021-pol2qm74 1152 30 by by IN cord-015021-pol2qm74 1152 31 4-fold 4-fold CD cord-015021-pol2qm74 1152 32 at at IN cord-015021-pol2qm74 1152 33 the the DT cord-015021-pol2qm74 1152 34 24 24 CD cord-015021-pol2qm74 1152 35 hour hour NN cord-015021-pol2qm74 1152 36 time time NN cord-015021-pol2qm74 1152 37 point point NN cord-015021-pol2qm74 1152 38 . . . cord-015021-pol2qm74 1153 1 Thus thus RB cord-015021-pol2qm74 1153 2 , , , cord-015021-pol2qm74 1153 3 the the DT cord-015021-pol2qm74 1153 4 recruitment recruitment NN cord-015021-pol2qm74 1153 5 of of IN cord-015021-pol2qm74 1153 6 different different JJ cord-015021-pol2qm74 1153 7 leukocyte leukocyte NN cord-015021-pol2qm74 1153 8 populations population NNS cord-015021-pol2qm74 1153 9 to to IN cord-015021-pol2qm74 1153 10 the the DT cord-015021-pol2qm74 1153 11 lungs lung NNS cord-015021-pol2qm74 1153 12 during during IN cord-015021-pol2qm74 1153 13 endotoxemia endotoxemia NN cord-015021-pol2qm74 1153 14 is be VBZ cord-015021-pol2qm74 1153 15 likely likely RB cord-015021-pol2qm74 1153 16 directed direct VBN cord-015021-pol2qm74 1153 17 by by IN cord-015021-pol2qm74 1153 18 different different JJ cord-015021-pol2qm74 1153 19 mechanisms mechanism NNS cord-015021-pol2qm74 1153 20 . . . cord-015021-pol2qm74 1154 1 Recent recent JJ cord-015021-pol2qm74 1154 2 studies study NNS cord-015021-pol2qm74 1154 3 have have VBP cord-015021-pol2qm74 1154 4 identified identify VBN cord-015021-pol2qm74 1154 5 a a DT cord-015021-pol2qm74 1154 6 supergene supergene JJ cord-015021-pol2qm74 1154 7 family family NN cord-015021-pol2qm74 1154 8 of of IN cord-015021-pol2qm74 1154 9 small small JJ cord-015021-pol2qm74 1154 10 inducible inducible JJ cord-015021-pol2qm74 1154 11 chemotactic chemotactic JJ cord-015021-pol2qm74 1154 12 cytokines cytokine NNS cord-015021-pol2qm74 1154 13 ( ( -LRB- cord-015021-pol2qm74 1154 14 chemukines chemukines NNP cord-015021-pol2qm74 1154 15 ) ) -RRB- cord-015021-pol2qm74 1154 16 which which WDT cord-015021-pol2qm74 1154 17 possesses possess VBZ cord-015021-pol2qm74 1154 18 chemotactic chemotactic VBN cord-015021-pol2qm74 1154 19 and and CC cord-015021-pol2qm74 1154 20 activating activate VBG cord-015021-pol2qm74 1154 21 properties property NNS cord-015021-pol2qm74 1154 22 for for IN cord-015021-pol2qm74 1154 23 neutrophils neutrophil NNS cord-015021-pol2qm74 1154 24 . . . cord-015021-pol2qm74 1155 1 The the DT cord-015021-pol2qm74 1155 2 prototype prototype NN cord-015021-pol2qm74 1155 3 of of IN cord-015021-pol2qm74 1155 4 this this DT cord-015021-pol2qm74 1155 5 family family NN cord-015021-pol2qm74 1155 6 is be VBZ cord-015021-pol2qm74 1155 7 interleukin-8 interleukin-8 NNP cord-015021-pol2qm74 1155 8 ( ( -LRB- cord-015021-pol2qm74 1155 9 IL-8 IL-8 NNP cord-015021-pol2qm74 1155 10 ) ) -RRB- cord-015021-pol2qm74 1155 11 . . . cord-015021-pol2qm74 1156 1 Interestingly interestingly RB cord-015021-pol2qm74 1156 2 , , , cord-015021-pol2qm74 1156 3 a a DT cord-015021-pol2qm74 1156 4 related relate VBN cord-015021-pol2qm74 1156 5 supergene supergene JJ cord-015021-pol2qm74 1156 6 family family NN cord-015021-pol2qm74 1156 7 has have VBZ cord-015021-pol2qm74 1156 8 been be VBN cord-015021-pol2qm74 1156 9 identified identify VBN cord-015021-pol2qm74 1156 10 which which WDT cord-015021-pol2qm74 1156 11 possesses possess VBZ cord-015021-pol2qm74 1156 12 activity activity NN cord-015021-pol2qm74 1156 13 for for IN cord-015021-pol2qm74 1156 14 recruiting recruit VBG cord-015021-pol2qm74 1156 15 mononuclear mononuclear JJ cord-015021-pol2qm74 1156 16 cells cell NNS cord-015021-pol2qm74 1156 17 . . . cord-015021-pol2qm74 1157 1 Examples example NNS cord-015021-pol2qm74 1157 2 of of IN cord-015021-pol2qm74 1157 3 this this DT cord-015021-pol2qm74 1157 4 group group NN cord-015021-pol2qm74 1157 5 of of IN cord-015021-pol2qm74 1157 6 inflammatory inflammatory JJ cord-015021-pol2qm74 1157 7 chemukines chemukine NNS cord-015021-pol2qm74 1157 8 are be VBP cord-015021-pol2qm74 1157 9 monocyte monocyte NNP cord-015021-pol2qm74 1157 10 chemotactic chemotactic JJ cord-015021-pol2qm74 1157 11 protein protein NN cord-015021-pol2qm74 1157 12 - - : cord-015021-pol2qm74 1157 13 i i NNP cord-015021-pol2qm74 1157 14 ( ( -LRB- cord-015021-pol2qm74 1157 15 MCP MCP NNP cord-015021-pol2qm74 1157 16 - - HYPH cord-015021-pol2qm74 1157 17 I I NNP cord-015021-pol2qm74 1157 18 ) ) -RRB- cord-015021-pol2qm74 1157 19 and and CC cord-015021-pol2qm74 1157 20 macrophage macrophage VB cord-015021-pol2qm74 1157 21 inflammatory inflammatory JJ cord-015021-pol2qm74 1157 22 protein protein NN cord-015021-pol2qm74 1157 23 - - : cord-015021-pol2qm74 1157 24 i i PRP cord-015021-pol2qm74 1157 25 alpha alpha NN cord-015021-pol2qm74 1157 26 ( ( -LRB- cord-015021-pol2qm74 1157 27 MIP MIP NNP cord-015021-pol2qm74 1157 28 - - HYPH cord-015021-pol2qm74 1157 29 I I NNP cord-015021-pol2qm74 1157 30 ) ) -RRB- cord-015021-pol2qm74 1157 31 . . . cord-015021-pol2qm74 1158 1 In in IN cord-015021-pol2qm74 1158 2 initial initial NN cord-015021-pol2qm74 1158 3 in in IN cord-015021-pol2qm74 1158 4 viva viva FW cord-015021-pol2qm74 1158 5 studies study NNS cord-015021-pol2qm74 1158 6 we -PRON- PRP cord-015021-pol2qm74 1158 7 examined examine VBD cord-015021-pol2qm74 1158 8 whether whether IN cord-015021-pol2qm74 1158 9 MIP MIP NNP cord-015021-pol2qm74 1158 10 - - HYPH cord-015021-pol2qm74 1158 11 I -PRON- PRP cord-015021-pol2qm74 1158 12 was be VBD cord-015021-pol2qm74 1158 13 expressed express VBN cord-015021-pol2qm74 1158 14 systemically systemically RB cord-015021-pol2qm74 1158 15 or or CC cord-015021-pol2qm74 1158 16 in in IN cord-015021-pol2qm74 1158 17 a a DT cord-015021-pol2qm74 1158 18 compartmentalized compartmentalized JJ cord-015021-pol2qm74 1158 19 fashion fashion NN cord-015021-pol2qm74 1158 20 post post NN cord-015021-pol2qm74 1158 21 LPS LPS NNP cord-015021-pol2qm74 1158 22 challenge challenge NN cord-015021-pol2qm74 1158 23 . . . cord-015021-pol2qm74 1159 1 Assessment assessment NN cord-015021-pol2qm74 1159 2 of of IN cord-015021-pol2qm74 1159 3 plasma plasma NN cord-015021-pol2qm74 1159 4 cytokine cytokine NN cord-015021-pol2qm74 1159 5 levels level NNS cord-015021-pol2qm74 1159 6 revealed reveal VBD cord-015021-pol2qm74 1159 7 maximal maximal JJ cord-015021-pol2qm74 1159 8 TNF TNF NNP cord-015021-pol2qm74 1159 9 levels level NNS cord-015021-pol2qm74 1159 10 occurred occur VBD cord-015021-pol2qm74 1159 11 I -PRON- PRP cord-015021-pol2qm74 1159 12 hour hour VBP cord-015021-pol2qm74 1159 13 post post NN cord-015021-pol2qm74 1159 14 LPS LPS NNP cord-015021-pol2qm74 1159 15 administration administration NN cord-015021-pol2qm74 1159 16 , , , cord-015021-pol2qm74 1159 17 returning return VBG cord-015021-pol2qm74 1159 18 to to IN cord-015021-pol2qm74 1159 19 baseline baseline NN cord-015021-pol2qm74 1159 20 by by IN cord-015021-pol2qm74 1159 21 4 4 CD cord-015021-pol2qm74 1159 22 hours hour NNS cord-015021-pol2qm74 1159 23 , , , cord-015021-pol2qm74 1159 24 while while IN cord-015021-pol2qm74 1159 25 MIP MIP NNP cord-015021-pol2qm74 1159 26 - - HYPH cord-015021-pol2qm74 1159 27 I -PRON- PRP cord-015021-pol2qm74 1159 28 levels level NNS cord-015021-pol2qm74 1159 29 were be VBD cord-015021-pol2qm74 1159 30 maximal maximal JJ cord-015021-pol2qm74 1159 31 at at IN cord-015021-pol2qm74 1159 32 2 2 CD cord-015021-pol2qm74 1159 33 hours hour NNS cord-015021-pol2qm74 1159 34 ( ( -LRB- cord-015021-pol2qm74 1159 35 2,5 2,5 CD cord-015021-pol2qm74 1159 36 ng ng NN cord-015021-pol2qm74 1159 37 / / SYM cord-015021-pol2qm74 1159 38 ml ml NNP cord-015021-pol2qm74 1159 39 ) ) -RRB- cord-015021-pol2qm74 1159 40 , , , cord-015021-pol2qm74 1159 41 with with IN cord-015021-pol2qm74 1159 42 a a DT cord-015021-pol2qm74 1159 43 second second JJ cord-015021-pol2qm74 1159 44 peak peak NN cord-015021-pol2qm74 1159 45 at at IN cord-015021-pol2qm74 1159 46 24 24 CD cord-015021-pol2qm74 1159 47 hours hour NNS cord-015021-pol2qm74 1159 48 after after IN cord-015021-pol2qm74 1159 49 LPS LPS NNP cord-015021-pol2qm74 1159 50 challenge challenge NN cord-015021-pol2qm74 1159 51 . . . cord-015021-pol2qm74 1160 1 Interestingly interestingly RB cord-015021-pol2qm74 1160 2 , , , cord-015021-pol2qm74 1160 3 aqueous aqueous JJ cord-015021-pol2qm74 1160 4 extracts extract NNS cord-015021-pol2qm74 1160 5 of of IN cord-015021-pol2qm74 1160 6 liver liver NN cord-015021-pol2qm74 1160 7 homogenates homogenate NNS cord-015021-pol2qm74 1160 8 from from IN cord-015021-pol2qm74 1160 9 LPS LPS NNP cord-015021-pol2qm74 1160 10 treated treat VBN cord-015021-pol2qm74 1160 11 animals animal NNS cord-015021-pol2qm74 1160 12 demonstrated demonstrate VBD cord-015021-pol2qm74 1160 13 no no DT cord-015021-pol2qm74 1160 14 MIP MIP NNP cord-015021-pol2qm74 1160 15 - - HYPH cord-015021-pol2qm74 1160 16 I -PRON- PRP cord-015021-pol2qm74 1160 17 levels level NNS cord-015021-pol2qm74 1160 18 , , , cord-015021-pol2qm74 1160 19 while while IN cord-015021-pol2qm74 1160 20 aqueous aqueous JJ cord-015021-pol2qm74 1160 21 extracts extract NNS cord-015021-pol2qm74 1160 22 of of IN cord-015021-pol2qm74 1160 23 lung lung NN cord-015021-pol2qm74 1160 24 revealed reveal VBD cord-015021-pol2qm74 1160 25 a a DT cord-015021-pol2qm74 1160 26 4-fold 4-fold CD cord-015021-pol2qm74 1160 27 increase increase NN cord-015021-pol2qm74 1160 28 in in IN cord-015021-pol2qm74 1160 29 MIP MIP NNP cord-015021-pol2qm74 1160 30 - - HYPH cord-015021-pol2qm74 1160 31 I -PRON- PRP cord-015021-pol2qm74 1160 32 levels level NNS cord-015021-pol2qm74 1160 33 over over IN cord-015021-pol2qm74 1160 34 control control NN cord-015021-pol2qm74 1160 35 lungs lung NNS cord-015021-pol2qm74 1160 36 . . . cord-015021-pol2qm74 1161 1 Immunohistochemical immunohistochemical JJ cord-015021-pol2qm74 1161 2 analysis analysis NN cord-015021-pol2qm74 1161 3 of of IN cord-015021-pol2qm74 1161 4 the the DT cord-015021-pol2qm74 1161 5 lungs lung NNS cord-015021-pol2qm74 1161 6 from from IN cord-015021-pol2qm74 1161 7 24 24 CD cord-015021-pol2qm74 1161 8 hour hour NN cord-015021-pol2qm74 1161 9 LPS lp NNS cord-015021-pol2qm74 1161 10 treated treat VBN cord-015021-pol2qm74 1161 11 animals animal NNS cord-015021-pol2qm74 1161 12 demonstrated demonstrate VBD cord-015021-pol2qm74 1161 13 the the DT cord-015021-pol2qm74 1161 14 alveolar alveolar JJ cord-015021-pol2qm74 1161 15 macrophage macrophage NN cord-015021-pol2qm74 1161 16 was be VBD cord-015021-pol2qm74 1161 17 a a DT cord-015021-pol2qm74 1161 18 rich rich JJ cord-015021-pol2qm74 1161 19 source source NN cord-015021-pol2qm74 1161 20 of of IN cord-015021-pol2qm74 1161 21 MIP MIP NNP cord-015021-pol2qm74 1161 22 - - HYPH cord-015021-pol2qm74 1161 23 I I NNP cord-015021-pol2qm74 1161 24 protein protein NN cord-015021-pol2qm74 1161 25 . . . cord-015021-pol2qm74 1162 1 Cell cell NN cord-015021-pol2qm74 1162 2 - - HYPH cord-015021-pol2qm74 1162 3 associated associate VBN cord-015021-pol2qm74 1162 4 MIP mip NN cord-015021-pol2qm74 1163 1 -I -I NNP cord-015021-pol2qm74 1163 2 was be VBD cord-015021-pol2qm74 1163 3 also also RB cord-015021-pol2qm74 1163 4 expressed express VBN cord-015021-pol2qm74 1163 5 by by IN cord-015021-pol2qm74 1163 6 blood blood NN cord-015021-pol2qm74 1163 7 monocytes monocyte NNS cord-015021-pol2qm74 1163 8 adherent adherent JJ cord-015021-pol2qm74 1163 9 to to IN cord-015021-pol2qm74 1163 10 the the DT cord-015021-pol2qm74 1163 11 pulmonary pulmonary JJ cord-015021-pol2qm74 1163 12 vascular vascular JJ cord-015021-pol2qm74 1163 13 endotheliun endotheliun NN cord-015021-pol2qm74 1163 14 , , , cord-015021-pol2qm74 1163 15 however however RB cord-015021-pol2qm74 1163 16 the the DT cord-015021-pol2qm74 1163 17 expression expression NN cord-015021-pol2qm74 1163 18 of of IN cord-015021-pol2qm74 1163 19 monocyte monocyte NNP cord-015021-pol2qm74 1163 20 - - HYPH cord-015021-pol2qm74 1163 21 MIP MIP NNP cord-015021-pol2qm74 1164 1 -i -i NNP cord-015021-pol2qm74 1164 2 was be VBD cord-015021-pol2qm74 1164 3 observed observe VBN cord-015021-pol2qm74 1164 4 by by IN cord-015021-pol2qm74 1164 5 2 2 CD cord-015021-pol2qm74 1164 6 hours hour NNS cord-015021-pol2qm74 1164 7 post post NN cord-015021-pol2qm74 1164 8 LPS LPS NNP cord-015021-pol2qm74 1164 9 administration administration NN cord-015021-pol2qm74 1164 10 . . . cord-015021-pol2qm74 1165 1 Immunohistochemical immunohistochemical JJ cord-015021-pol2qm74 1165 2 analysis analysis NN cord-015021-pol2qm74 1165 3 also also RB cord-015021-pol2qm74 1165 4 demonstrated demonstrate VBD cord-015021-pol2qm74 1165 5 that that IN cord-015021-pol2qm74 1165 6 MIP MIP NNP cord-015021-pol2qm74 1165 7 - - HYPH cord-015021-pol2qm74 1165 8 I I NNP cord-015021-pol2qm74 1165 9 antigen antigen NN cord-015021-pol2qm74 1165 10 is be VBZ cord-015021-pol2qm74 1165 11 associated associate VBN cord-015021-pol2qm74 1165 12 with with IN cord-015021-pol2qm74 1165 13 the the DT cord-015021-pol2qm74 1165 14 extracellular extracellular JJ cord-015021-pol2qm74 1165 15 matrix matrix NN cord-015021-pol2qm74 1165 16 on on IN cord-015021-pol2qm74 1165 17 the the DT cord-015021-pol2qm74 1165 18 interstitial interstitial JJ cord-015021-pol2qm74 1165 19 side side NN cord-015021-pol2qm74 1165 20 of of IN cord-015021-pol2qm74 1165 21 the the DT cord-015021-pol2qm74 1165 22 endothelium endothelium NN cord-015021-pol2qm74 1165 23 . . . cord-015021-pol2qm74 1166 1 This this DT cord-015021-pol2qm74 1166 2 suggests suggest VBZ cord-015021-pol2qm74 1166 3 that that IN cord-015021-pol2qm74 1166 4 the the DT cord-015021-pol2qm74 1166 5 extracellular extracellular JJ cord-015021-pol2qm74 1166 6 matrix matrix NN cord-015021-pol2qm74 1166 7 , , , cord-015021-pol2qm74 1166 8 which which WDT cord-015021-pol2qm74 1166 9 is be VBZ cord-015021-pol2qm74 1166 10 produced produce VBN cord-015021-pol2qm74 1166 11 during during IN cord-015021-pol2qm74 1166 12 inflammation inflammation NN cord-015021-pol2qm74 1166 13 , , , cord-015021-pol2qm74 1166 14 can can MD cord-015021-pol2qm74 1166 15 bind bind VB cord-015021-pol2qm74 1166 16 MIP MIP NNP cord-015021-pol2qm74 1166 17 - - HYPH cord-015021-pol2qm74 1166 18 I I NNP cord-015021-pol2qm74 1166 19 and and CC cord-015021-pol2qm74 1166 20 this this DT cord-015021-pol2qm74 1166 21 may may MD cord-015021-pol2qm74 1166 22 serve serve VB cord-015021-pol2qm74 1166 23 as as IN cord-015021-pol2qm74 1166 24 a a DT cord-015021-pol2qm74 1166 25 depot depot NN cord-015021-pol2qm74 1166 26 for for IN cord-015021-pol2qm74 1166 27 the the DT cord-015021-pol2qm74 1166 28 prolonged prolonged JJ cord-015021-pol2qm74 1166 29 presence presence NN cord-015021-pol2qm74 1166 30 of of IN cord-015021-pol2qm74 1166 31 NIP-1 NIP-1 NNP cord-015021-pol2qm74 1166 32 . . . cord-015021-pol2qm74 1167 1 In in IN cord-015021-pol2qm74 1167 2 additional additional JJ cord-015021-pol2qm74 1167 3 studies study NNS cord-015021-pol2qm74 1167 4 we -PRON- PRP cord-015021-pol2qm74 1167 5 have have VBP cord-015021-pol2qm74 1167 6 demonstrated demonstrate VBN cord-015021-pol2qm74 1167 7 that that IN cord-015021-pol2qm74 1167 8 the the DT cord-015021-pol2qm74 1167 9 intratracheal intratracheal JJ cord-015021-pol2qm74 1167 10 instillation instillation NN cord-015021-pol2qm74 1167 11 of of IN cord-015021-pol2qm74 1167 12 rMuI rmui DT cord-015021-pol2qm74 1167 13 [ [ -LRB- cord-015021-pol2qm74 1167 14 IP IP NNP cord-015021-pol2qm74 1167 15 - - HYPH cord-015021-pol2qm74 1167 16 l(lOOng l(lOOng NNP cord-015021-pol2qm74 1167 17 ) ) -RRB- cord-015021-pol2qm74 1167 18 _SP cord-015021-pol2qm74 1167 19 Activation Activation NNP cord-015021-pol2qm74 1167 20 of of IN cord-015021-pol2qm74 1167 21 polymorphonuclear polymorphonuclear JJ cord-015021-pol2qm74 1167 22 leukocytes leukocyte NNS cord-015021-pol2qm74 1167 23 by by IN cord-015021-pol2qm74 1167 24 inflammatory inflammatory JJ cord-015021-pol2qm74 1167 25 stimuli stimulus NNS cord-015021-pol2qm74 1167 26 may may MD cord-015021-pol2qm74 1167 27 contribute contribute VB cord-015021-pol2qm74 1167 28 to to IN cord-015021-pol2qm74 1167 29 the the DT cord-015021-pol2qm74 1167 30 development development NN cord-015021-pol2qm74 1167 31 of of IN cord-015021-pol2qm74 1167 32 multiple multiple JJ cord-015021-pol2qm74 1167 33 organ organ NN cord-015021-pol2qm74 1167 34 failure failure NN cord-015021-pol2qm74 1167 35 in in IN cord-015021-pol2qm74 1167 36 septic septic JJ cord-015021-pol2qm74 1167 37 patients patient NNS cord-015021-pol2qm74 1167 38 . . . cord-015021-pol2qm74 1168 1 Thereby thereby RB cord-015021-pol2qm74 1168 2 PMNL PMNL NNP cord-015021-pol2qm74 1168 3 are be VBP cord-015021-pol2qm74 1168 4 proposed propose VBN cord-015021-pol2qm74 1168 5 to to TO cord-015021-pol2qm74 1168 6 avidly avidly RB cord-015021-pol2qm74 1168 7 adhere adhere VB cord-015021-pol2qm74 1168 8 to to IN cord-015021-pol2qm74 1168 9 vascular vascular JJ cord-015021-pol2qm74 1168 10 endothelium endothelium NN cord-015021-pol2qm74 1168 11 causing cause VBG cord-015021-pol2qm74 1168 12 damage damage NN cord-015021-pol2qm74 1168 13 by by IN cord-015021-pol2qm74 1168 14 the the DT cord-015021-pol2qm74 1168 15 subsequent subsequent JJ cord-015021-pol2qm74 1168 16 release release NN cord-015021-pol2qm74 1168 17 of of IN cord-015021-pol2qm74 1168 18 toxic toxic JJ cord-015021-pol2qm74 1168 19 agents agent NNS cord-015021-pol2qm74 1168 20 . . . cord-015021-pol2qm74 1169 1 As as IN cord-015021-pol2qm74 1169 2 cellular cellular JJ cord-015021-pol2qm74 1169 3 adhesion adhesion NN cord-015021-pol2qm74 1169 4 is be VBZ cord-015021-pol2qm74 1169 5 primarily primarily RB cord-015021-pol2qm74 1169 6 mediated mediate VBN cord-015021-pol2qm74 1169 7 by by IN cord-015021-pol2qm74 1169 8 62-integrins 62-integrins CD cord-015021-pol2qm74 1169 9 and and CC cord-015021-pol2qm74 1169 10 Lselectins Lselectins NNP cord-015021-pol2qm74 1169 11 , , , cord-015021-pol2qm74 1169 12 the the DT cord-015021-pol2qm74 1169 13 present present JJ cord-015021-pol2qm74 1169 14 study study NN cord-015021-pol2qm74 1169 15 compares compare VBZ cord-015021-pol2qm74 1169 16 the the DT cord-015021-pol2qm74 1169 17 expression expression NN cord-015021-pol2qm74 1169 18 of of IN cord-015021-pol2qm74 1169 19 these these DT cord-015021-pol2qm74 1169 20 adhesionmolecules adhesionmolecule NNS cord-015021-pol2qm74 1169 21 on on IN cord-015021-pol2qm74 1169 22 PMNL PMNL NNP cord-015021-pol2qm74 1169 23 in in IN cord-015021-pol2qm74 1169 24 septic septic JJ cord-015021-pol2qm74 1169 25 patients patient NNS cord-015021-pol2qm74 1169 26 and and CC cord-015021-pol2qm74 1169 27 healthy healthy JJ cord-015021-pol2qm74 1169 28 volunteers volunteer NNS cord-015021-pol2qm74 1169 29 . . . cord-015021-pol2qm74 1170 1 Methods method NNS cord-015021-pol2qm74 1170 2 : : : cord-015021-pol2qm74 1170 3 Expression expression NN cord-015021-pol2qm74 1170 4 of of IN cord-015021-pol2qm74 1170 5 62-integrins 62-integrins CD cord-015021-pol2qm74 1170 6 and and CC cord-015021-pol2qm74 1170 7 L l NN cord-015021-pol2qm74 1170 8 - - HYPH cord-015021-pol2qm74 1170 9 selectins selectin NNS cord-015021-pol2qm74 1170 10 on on IN cord-015021-pol2qm74 1170 11 PMNL PMNL NNP cord-015021-pol2qm74 1170 12 was be VBD cord-015021-pol2qm74 1170 13 measured measure VBN cord-015021-pol2qm74 1170 14 in in IN cord-015021-pol2qm74 1170 15 whole whole JJ cord-015021-pol2qm74 1170 16 blood blood NN cord-015021-pol2qm74 1170 17 by by IN cord-015021-pol2qm74 1170 18 flow flow NN cord-015021-pol2qm74 1170 19 cytometry cytometry NN cord-015021-pol2qm74 1170 20 using use VBG cord-015021-pol2qm74 1170 21 the the DT cord-015021-pol2qm74 1170 22 monoclonal monoclonal JJ cord-015021-pol2qm74 1170 23 antibodies antibody NNS cord-015021-pol2qm74 1170 24 IB4 IB4 NNP cord-015021-pol2qm74 1170 25 and and CC cord-015021-pol2qm74 1170 26 Dreg Dreg NNP cord-015021-pol2qm74 1170 27 200 200 CD cord-015021-pol2qm74 1170 28 , , , cord-015021-pol2qm74 1170 29 Baseline baseline JJ cord-015021-pol2qm74 1170 30 values value NNS cord-015021-pol2qm74 1170 31 were be VBD cord-015021-pol2qm74 1170 32 determined determine VBN cord-015021-pol2qm74 1170 33 immediatley immediatley RB cord-015021-pol2qm74 1170 34 after after IN cord-015021-pol2qm74 1170 35 drawing draw VBG cord-015021-pol2qm74 1170 36 blood blood NN cord-015021-pol2qm74 1170 37 . . . cord-015021-pol2qm74 1171 1 In in IN cord-015021-pol2qm74 1171 2 addition addition NN cord-015021-pol2qm74 1171 3 cells cell NNS cord-015021-pol2qm74 1171 4 were be VBD cord-015021-pol2qm74 1171 5 incubated incubate VBN cord-015021-pol2qm74 1171 6 45 45 CD cord-015021-pol2qm74 1171 7 min min NN cord-015021-pol2qm74 1171 8 at at IN cord-015021-pol2qm74 1171 9 37 37 CD cord-015021-pol2qm74 1171 10 ° ° NN cord-015021-pol2qm74 1171 11 C c NN cord-015021-pol2qm74 1171 12 to to TO cord-015021-pol2qm74 1171 13 allow allow VB cord-015021-pol2qm74 1171 14 for for IN cord-015021-pol2qm74 1171 15 spontaneous spontaneous JJ cord-015021-pol2qm74 1171 16 regulation regulation NN cord-015021-pol2qm74 1171 17 of of IN cord-015021-pol2qm74 1171 18 adhesion adhesion NN cord-015021-pol2qm74 1171 19 molecules molecule NNS cord-015021-pol2qm74 1171 20 . . . cord-015021-pol2qm74 1172 1 55 55 CD cord-015021-pol2qm74 1172 2 blood blood NN cord-015021-pol2qm74 1172 3 specimens specimen NNS cord-015021-pol2qm74 1172 4 from from IN cord-015021-pol2qm74 1172 5 8 8 CD cord-015021-pol2qm74 1172 6 septic septic JJ cord-015021-pol2qm74 1172 7 patients patient NNS cord-015021-pol2qm74 1172 8 were be VBD cord-015021-pol2qm74 1172 9 obtained obtain VBN cord-015021-pol2qm74 1172 10 during during IN cord-015021-pol2qm74 1172 11 the the DT cord-015021-pol2qm74 1172 12 course course NN cord-015021-pol2qm74 1172 13 of of IN cord-015021-pol2qm74 1172 14 their -PRON- PRP$ cord-015021-pol2qm74 1172 15 illness illness NN cord-015021-pol2qm74 1172 16 . . . cord-015021-pol2qm74 1173 1 Control control NN cord-015021-pol2qm74 1173 2 values value NNS cord-015021-pol2qm74 1173 3 were be VBD cord-015021-pol2qm74 1173 4 determined determine VBN cord-015021-pol2qm74 1173 5 in in IN cord-015021-pol2qm74 1173 6 12 12 CD cord-015021-pol2qm74 1173 7 healthy healthy JJ cord-015021-pol2qm74 1173 8 volunteers volunteer NNS cord-015021-pol2qm74 1173 9 . . . cord-015021-pol2qm74 1174 1 Results result NNS cord-015021-pol2qm74 1174 2 : : : cord-015021-pol2qm74 1175 1 Baseline baseline JJ cord-015021-pol2qm74 1175 2 expression expression NN cord-015021-pol2qm74 1175 3 of of IN cord-015021-pol2qm74 1175 4 62-integrins 62-integrins CD cord-015021-pol2qm74 1175 5 and and CC cord-015021-pol2qm74 1175 6 L l NN cord-015021-pol2qm74 1175 7 - - HYPH cord-015021-pol2qm74 1175 8 selectins selectins NNP cord-015021-pol2qm74 1175 9 was be VBD cord-015021-pol2qm74 1175 10 not not RB cord-015021-pol2qm74 1175 11 signifcantly signifcantly RB cord-015021-pol2qm74 1175 12 different different JJ cord-015021-pol2qm74 1175 13 in in IN cord-015021-pol2qm74 1175 14 septic septic NN cord-015021-pol2qm74 1175 15 and and CC cord-015021-pol2qm74 1175 16 in in IN cord-015021-pol2qm74 1175 17 healthy healthy JJ cord-015021-pol2qm74 1175 18 subjects subject NNS cord-015021-pol2qm74 1175 19 . . . cord-015021-pol2qm74 1176 1 In in IN cord-015021-pol2qm74 1176 2 contrast contrast NN cord-015021-pol2qm74 1176 3 , , , cord-015021-pol2qm74 1176 4 there there EX cord-015021-pol2qm74 1176 5 was be VBD cord-015021-pol2qm74 1176 6 a a DT cord-015021-pol2qm74 1176 7 significant significant JJ cord-015021-pol2qm74 1176 8 upregulation upregulation NN cord-015021-pol2qm74 1176 9 of of IN cord-015021-pol2qm74 1176 10 g2-integrins g2-integrin NNS cord-015021-pol2qm74 1176 11 and and CC cord-015021-pol2qm74 1176 12 shedding shedding NN cord-015021-pol2qm74 1176 13 of of IN cord-015021-pol2qm74 1176 14 L l NN cord-015021-pol2qm74 1176 15 - - HYPH cord-015021-pol2qm74 1176 16 selectins selectin NNS cord-015021-pol2qm74 1176 17 of of IN cord-015021-pol2qm74 1176 18 PMNL PMNL NNP cord-015021-pol2qm74 1176 19 in in IN cord-015021-pol2qm74 1176 20 septic septic JJ cord-015021-pol2qm74 1176 21 patients patient NNS cord-015021-pol2qm74 1176 22 ( ( -LRB- cord-015021-pol2qm74 1176 23 SP SP NNP cord-015021-pol2qm74 1176 24 ) ) -RRB- cord-015021-pol2qm74 1176 25 compared compare VBN cord-015021-pol2qm74 1176 26 to to IN cord-015021-pol2qm74 1176 27 healthy healthy JJ cord-015021-pol2qm74 1176 28 volunteers volunteer NNS cord-015021-pol2qm74 1176 29 ( ( -LRB- cord-015021-pol2qm74 1176 30 HV HV NNP cord-015021-pol2qm74 1176 31 ) ) -RRB- cord-015021-pol2qm74 1176 32 . . . cord-015021-pol2qm74 1177 1 The the DT cord-015021-pol2qm74 1177 2 local local JJ cord-015021-pol2qm74 1177 3 or or CC cord-015021-pol2qm74 1177 4 systemic systemic JJ cord-015021-pol2qm74 1177 5 production production NN cord-015021-pol2qm74 1177 6 of of IN cord-015021-pol2qm74 1177 7 inflammatory inflammatory JJ cord-015021-pol2qm74 1177 8 cytokines cytokine NNS cord-015021-pol2qm74 1177 9 , , , cord-015021-pol2qm74 1177 10 such such JJ cord-015021-pol2qm74 1177 11 as as IN cord-015021-pol2qm74 1177 12 tumor tumor NN cord-015021-pol2qm74 1177 13 necrosis necrosis NN cord-015021-pol2qm74 1177 14 factor factor NN cord-015021-pol2qm74 1177 15 alpha alpha NN cord-015021-pol2qm74 1177 16 ( ( -LRB- cord-015021-pol2qm74 1177 17 TNFc~ TNFc~ NNP cord-015021-pol2qm74 1177 18 ) ) -RRB- cord-015021-pol2qm74 1177 19 , , , cord-015021-pol2qm74 1177 20 can can MD cord-015021-pol2qm74 1177 21 serve serve VB cord-015021-pol2qm74 1177 22 to to TO cord-015021-pol2qm74 1177 23 modulate modulate VB cord-015021-pol2qm74 1177 24 multiple multiple JJ cord-015021-pol2qm74 1177 25 aspects aspect NNS cord-015021-pol2qm74 1177 26 of of IN cord-015021-pol2qm74 1177 27 neutrophil neutrophil NN cord-015021-pol2qm74 1177 28 function function NN cord-015021-pol2qm74 1177 29 . . . cord-015021-pol2qm74 1178 1 The the DT cord-015021-pol2qm74 1178 2 ability ability NN cord-015021-pol2qm74 1178 3 of of IN cord-015021-pol2qm74 1178 4 neutrophils neutrophil NNS cord-015021-pol2qm74 1178 5 to to TO cord-015021-pol2qm74 1178 6 leave leave VB cord-015021-pol2qm74 1178 7 the the DT cord-015021-pol2qm74 1178 8 circulation circulation NN cord-015021-pol2qm74 1178 9 and and CC cord-015021-pol2qm74 1178 10 migrate migrate VB cord-015021-pol2qm74 1178 11 to to IN cord-015021-pol2qm74 1178 12 areas area NNS cord-015021-pol2qm74 1178 13 of of IN cord-015021-pol2qm74 1178 14 infection infection NN cord-015021-pol2qm74 1178 15 is be VBZ cord-015021-pol2qm74 1178 16 one one CD cord-015021-pol2qm74 1178 17 essential essential JJ cord-015021-pol2qm74 1178 18 component component NN cord-015021-pol2qm74 1178 19 of of IN cord-015021-pol2qm74 1178 20 host host NN cord-015021-pol2qm74 1178 21 defense defense NN cord-015021-pol2qm74 1178 22 . . . cord-015021-pol2qm74 1179 1 L L NNP cord-015021-pol2qm74 1179 2 - - HYPH cord-015021-pol2qm74 1179 3 selectin selectin NNP cord-015021-pol2qm74 1179 4 , , , cord-015021-pol2qm74 1179 5 a a DT cord-015021-pol2qm74 1179 6 leucocyte leucocyte RB cord-015021-pol2qm74 1179 7 - - HYPH cord-015021-pol2qm74 1179 8 associated associate VBN cord-015021-pol2qm74 1179 9 adhesion adhesion NN cord-015021-pol2qm74 1179 10 molecule molecule NN cord-015021-pol2qm74 1179 11 , , , cord-015021-pol2qm74 1179 12 is be VBZ cord-015021-pol2qm74 1179 13 responsible responsible JJ cord-015021-pol2qm74 1179 14 for for IN cord-015021-pol2qm74 1179 15 the the DT cord-015021-pol2qm74 1179 16 initial initial JJ cord-015021-pol2qm74 1179 17 reversible reversible JJ cord-015021-pol2qm74 1179 18 contact contact NN cord-015021-pol2qm74 1179 19 between between IN cord-015021-pol2qm74 1179 20 neutrophils neutrophil NNS cord-015021-pol2qm74 1179 21 and and CC cord-015021-pol2qm74 1179 22 endothelium endothelium NN cord-015021-pol2qm74 1179 23 and and CC cord-015021-pol2qm74 1179 24 the the DT cord-015021-pol2qm74 1179 25 subsequent subsequent JJ cord-015021-pol2qm74 1179 26 roiling roil VBG cord-015021-pol2qm74 1179 27 action action NN cord-015021-pol2qm74 1179 28 of of IN cord-015021-pol2qm74 1179 29 neutrophils neutrophil NNS cord-015021-pol2qm74 1179 30 along along IN cord-015021-pol2qm74 1179 31 the the DT cord-015021-pol2qm74 1179 32 vessel vessel NN cord-015021-pol2qm74 1179 33 wall wall NN cord-015021-pol2qm74 1179 34 . . . cord-015021-pol2qm74 1180 1 In in IN cord-015021-pol2qm74 1180 2 contrast contrast NN cord-015021-pol2qm74 1180 3 to to IN cord-015021-pol2qm74 1180 4 other other JJ cord-015021-pol2qm74 1180 5 adhesion adhesion NN cord-015021-pol2qm74 1180 6 molecules molecule NNS cord-015021-pol2qm74 1180 7 , , , cord-015021-pol2qm74 1180 8 L L NNP cord-015021-pol2qm74 1180 9 - - HYPH cord-015021-pol2qm74 1180 10 selectin selectin NNP cord-015021-pol2qm74 1180 11 expression expression NN cord-015021-pol2qm74 1180 12 is be VBZ cord-015021-pol2qm74 1180 13 rapidly rapidly RB cord-015021-pol2qm74 1180 14 down down RB cord-015021-pol2qm74 1180 15 - - HYPH cord-015021-pol2qm74 1180 16 regulated regulate VBN cord-015021-pol2qm74 1180 17 after after IN cord-015021-pol2qm74 1180 18 neutrophil neutrophil NN cord-015021-pol2qm74 1180 19 activation activation NN cord-015021-pol2qm74 1180 20 . . . cord-015021-pol2qm74 1181 1 The the DT cord-015021-pol2qm74 1181 2 loss loss NN cord-015021-pol2qm74 1181 3 of of IN cord-015021-pol2qm74 1181 4 L L NNP cord-015021-pol2qm74 1181 5 - - HYPH cord-015021-pol2qm74 1181 6 seleclin seleclin NNP cord-015021-pol2qm74 1181 7 may may MD cord-015021-pol2qm74 1181 8 thus thus RB cord-015021-pol2qm74 1181 9 be be VB cord-015021-pol2qm74 1181 10 a a DT cord-015021-pol2qm74 1181 11 critical critical JJ cord-015021-pol2qm74 1181 12 determinant determinant NN cord-015021-pol2qm74 1181 13 of of IN cord-015021-pol2qm74 1181 14 how how WRB cord-015021-pol2qm74 1181 15 neutrophils neutrophil NNS cord-015021-pol2qm74 1181 16 become become VBP cord-015021-pol2qm74 1181 17 unbound unbound JJ cord-015021-pol2qm74 1181 18 from from IN cord-015021-pol2qm74 1181 19 their -PRON- PRP$ cord-015021-pol2qm74 1181 20 endothelial endothelial JJ cord-015021-pol2qm74 1181 21 attachments attachment NNS cord-015021-pol2qm74 1181 22 and and CC cord-015021-pol2qm74 1181 23 enabled enable VBD cord-015021-pol2qm74 1181 24 to to TO cord-015021-pol2qm74 1181 25 proceed proceed VB cord-015021-pol2qm74 1181 26 towards towards IN cord-015021-pol2qm74 1181 27 an an DT cord-015021-pol2qm74 1181 28 underlying underlie VBG cord-015021-pol2qm74 1181 29 extravascular extravascular JJ cord-015021-pol2qm74 1181 30 area area NN cord-015021-pol2qm74 1181 31 of of IN cord-015021-pol2qm74 1181 32 infection infection NN cord-015021-pol2qm74 1181 33 . . . cord-015021-pol2qm74 1182 1 We -PRON- PRP cord-015021-pol2qm74 1182 2 hypothesize hypothesize VBP cord-015021-pol2qm74 1182 3 that that IN cord-015021-pol2qm74 1182 4 the the DT cord-015021-pol2qm74 1182 5 shedding shedding NN cord-015021-pol2qm74 1182 6 of of IN cord-015021-pol2qm74 1182 7 L L NNP cord-015021-pol2qm74 1182 8 - - HYPH cord-015021-pol2qm74 1182 9 selectin selectin NNP cord-015021-pol2qm74 1182 10 is be VBZ cord-015021-pol2qm74 1182 11 a a DT cord-015021-pol2qm74 1182 12 strictly strictly RB cord-015021-pol2qm74 1182 13 controlled control VBN cord-015021-pol2qm74 1182 14 process process NN cord-015021-pol2qm74 1182 15 , , , cord-015021-pol2qm74 1182 16 occurring occur VBG cord-015021-pol2qm74 1182 17 primarily primarily RB cord-015021-pol2qm74 1182 18 at at IN cord-015021-pol2qm74 1182 19 localized localize VBN cord-015021-pol2qm74 1182 20 sites site NNS cord-015021-pol2qm74 1182 21 of of IN cord-015021-pol2qm74 1182 22 inflammation inflammation NN cord-015021-pol2qm74 1182 23 , , , cord-015021-pol2qm74 1182 24 which which WDT cord-015021-pol2qm74 1182 25 may may MD cord-015021-pol2qm74 1182 26 be be VB cord-015021-pol2qm74 1182 27 modulated modulate VBN cord-015021-pol2qm74 1182 28 by by IN cord-015021-pol2qm74 1182 29 TNF~ tnf~ CD cord-015021-pol2qm74 1182 30 , , , cord-015021-pol2qm74 1182 31 A a DT cord-015021-pol2qm74 1182 32 flow flow NN cord-015021-pol2qm74 1182 33 cytometric cytometric NN cord-015021-pol2qm74 1182 34 method method NN cord-015021-pol2qm74 1182 35 of of IN cord-015021-pol2qm74 1182 36 staining stain VBG cord-015021-pol2qm74 1182 37 neutrophHs neutrophh NNS cord-015021-pol2qm74 1182 38 by by IN cord-015021-pol2qm74 1182 39 monoclonal monoclonal JJ cord-015021-pol2qm74 1182 40 antibodies antibody NNS cord-015021-pol2qm74 1182 41 in in IN cord-015021-pol2qm74 1182 42 whole whole JJ cord-015021-pol2qm74 1182 43 blood blood NN cord-015021-pol2qm74 1182 44 is be VBZ cord-015021-pol2qm74 1182 45 described describe VBN cord-015021-pol2qm74 1182 46 whereby whereby WRB cord-015021-pol2qm74 1182 47 the the DT cord-015021-pol2qm74 1182 48 kinetics kinetic NNS cord-015021-pol2qm74 1182 49 of of IN cord-015021-pol2qm74 1182 50 L L NNP cord-015021-pol2qm74 1182 51 - - HYPH cord-015021-pol2qm74 1182 52 selectin selectin NNP cord-015021-pol2qm74 1182 53 shedding shedding NN cord-015021-pol2qm74 1182 54 may may MD cord-015021-pol2qm74 1182 55 be be VB cord-015021-pol2qm74 1182 56 followed follow VBN cord-015021-pol2qm74 1182 57 in in IN cord-015021-pol2qm74 1182 58 real real JJ cord-015021-pol2qm74 1182 59 time time NN cord-015021-pol2qm74 1182 60 . . . cord-015021-pol2qm74 1183 1 The the DT cord-015021-pol2qm74 1183 2 dose dose JJ cord-015021-pol2qm74 1183 3 response response NN cord-015021-pol2qm74 1183 4 and and CC cord-015021-pol2qm74 1183 5 time time NN cord-015021-pol2qm74 1183 6 course course NN cord-015021-pol2qm74 1183 7 of of IN cord-015021-pol2qm74 1183 8 in in IN cord-015021-pol2qm74 1183 9 - - HYPH cord-015021-pol2qm74 1183 10 vitro vitro FW cord-015021-pol2qm74 1183 11 L l NN cord-015021-pol2qm74 1183 12 - - HYPH cord-015021-pol2qm74 1183 13 selectin selectin NNP cord-015021-pol2qm74 1183 14 shedding shed VBG cord-015021-pol2qm74 1183 15 by by IN cord-015021-pol2qm74 1183 16 neutrophils neutrophil NNS cord-015021-pol2qm74 1183 17 from from IN cord-015021-pol2qm74 1183 18 normal normal JJ cord-015021-pol2qm74 1183 19 human human JJ cord-015021-pol2qm74 1183 20 subjects subject NNS cord-015021-pol2qm74 1183 21 was be VBD cord-015021-pol2qm74 1183 22 assayed assay VBN cord-015021-pol2qm74 1183 23 after after IN cord-015021-pol2qm74 1183 24 exposure exposure NN cord-015021-pol2qm74 1183 25 to to IN cord-015021-pol2qm74 1183 26 N N NNP cord-015021-pol2qm74 1183 27 - - HYPH cord-015021-pol2qm74 1183 28 formyl formyl NNP cord-015021-pol2qm74 1183 29 - - HYPH cord-015021-pol2qm74 1183 30 methionylleucyl methionylleucyl NN cord-015021-pol2qm74 1183 31 - - HYPH cord-015021-pol2qm74 1183 32 phenylalanine phenylalanine NN cord-015021-pol2qm74 1183 33 ( ( -LRB- cord-015021-pol2qm74 1183 34 FMLP FMLP NNP cord-015021-pol2qm74 1183 35 ) ) -RRB- cord-015021-pol2qm74 1183 36 and and CC cord-015021-pol2qm74 1183 37 TNFc~. TNFc~. NNP cord-015021-pol2qm74 1183 38 either either CC cord-015021-pol2qm74 1183 39 singly singly RB cord-015021-pol2qm74 1183 40 or or CC cord-015021-pol2qm74 1183 41 in in IN cord-015021-pol2qm74 1183 42 combination combination NN cord-015021-pol2qm74 1184 1 , , , cord-015021-pol2qm74 1184 2 Our -PRON- PRP$ cord-015021-pol2qm74 1184 3 results result NNS cord-015021-pol2qm74 1184 4 show show VBP cord-015021-pol2qm74 1184 5 that that IN cord-015021-pol2qm74 1184 6 L L NNP cord-015021-pol2qm74 1184 7 - - HYPH cord-015021-pol2qm74 1184 8 selectin selectin NNP cord-015021-pol2qm74 1184 9 shedding shedding NN cord-015021-pol2qm74 1184 10 can can MD cord-015021-pol2qm74 1184 11 be be VB cord-015021-pol2qm74 1184 12 reliably reliably RB cord-015021-pol2qm74 1184 13 followed follow VBN cord-015021-pol2qm74 1184 14 over over IN cord-015021-pol2qm74 1184 15 time time NN cord-015021-pol2qm74 1184 16 . . . cord-015021-pol2qm74 1185 1 A a DT cord-015021-pol2qm74 1185 2 significant significant JJ cord-015021-pol2qm74 1185 3 percentage percentage NN cord-015021-pol2qm74 1185 4 of of IN cord-015021-pol2qm74 1185 5 cells cell NNS cord-015021-pol2qm74 1185 6 shed shed VBP cord-015021-pol2qm74 1185 7 L L NNP cord-015021-pol2qm74 1185 8 - - HYPH cord-015021-pol2qm74 1185 9 selectin selectin NNP cord-015021-pol2qm74 1185 10 after after IN cord-015021-pol2qm74 1185 11 exposure exposure NN cord-015021-pol2qm74 1185 12 to to IN cord-015021-pol2qm74 1185 13 2000 2000 CD cord-015021-pol2qm74 1185 14 pg pg NN cord-015021-pol2qm74 1185 15 / / SYM cord-015021-pol2qm74 1185 16 ml ml NNP cord-015021-pol2qm74 1185 17 TNFc~ TNFc~ NNP cord-015021-pol2qm74 1185 18 or or CC cord-015021-pol2qm74 1185 19 1000nM 1000nm CD cord-015021-pol2qm74 1185 20 FMLP FMLP NNP cord-015021-pol2qm74 1185 21 ( ( -LRB- cord-015021-pol2qm74 1186 1 but but CC cord-015021-pol2qm74 1186 2 not not RB cord-015021-pol2qm74 1186 3 at at IN cord-015021-pol2qm74 1186 4 400pg/ 400pg/ CD cord-015021-pol2qm74 1187 1 ml ml NNP cord-015021-pol2qm74 1188 1 TNFc~ tnfc~ CD cord-015021-pol2qm74 1188 2 or or CC cord-015021-pol2qm74 1188 3 200nM 200nM VBN cord-015021-pol2qm74 1188 4 FMLP FMLP NNP cord-015021-pol2qm74 1188 5 ) ) -RRB- cord-015021-pol2qm74 1188 6 . . . cord-015021-pol2qm74 1189 1 Greater great JJR cord-015021-pol2qm74 1189 2 numbers number NNS cord-015021-pol2qm74 1189 3 of of IN cord-015021-pol2qm74 1189 4 cells cell NNS cord-015021-pol2qm74 1189 5 were be VBD cord-015021-pol2qm74 1189 6 able able JJ cord-015021-pol2qm74 1189 7 to to TO cord-015021-pol2qm74 1189 8 shed shed VB cord-015021-pol2qm74 1189 9 their -PRON- PRP$ cord-015021-pol2qm74 1189 10 L l NN cord-015021-pol2qm74 1189 11 - - HYPH cord-015021-pol2qm74 1189 12 selectin selectin NNP cord-015021-pol2qm74 1189 13 when when WRB cord-015021-pol2qm74 1189 14 FMLP FMLP NNP cord-015021-pol2qm74 1189 15 and and CC cord-015021-pol2qm74 1189 16 TNF TNF NNP cord-015021-pol2qm74 1189 17 ~ ~ NFP cord-015021-pol2qm74 1189 18 x x : cord-015021-pol2qm74 1189 19 were be VBD cord-015021-pol2qm74 1189 20 presented present VBN cord-015021-pol2qm74 1189 21 in in IN cord-015021-pol2qm74 1189 22 combination combination NN cord-015021-pol2qm74 1189 23 rather rather RB cord-015021-pol2qm74 1189 24 than than IN cord-015021-pol2qm74 1189 25 alone alone JJ cord-015021-pol2qm74 1189 26 . . . cord-015021-pol2qm74 1190 1 High high JJ cord-015021-pol2qm74 1190 2 levels level NNS cord-015021-pol2qm74 1190 3 of of IN cord-015021-pol2qm74 1190 4 TNFc~ TNFc~ NNP cord-015021-pol2qm74 1190 5 did do VBD cord-015021-pol2qm74 1190 6 not not RB cord-015021-pol2qm74 1190 7 appear appear VB cord-015021-pol2qm74 1190 8 to to TO cord-015021-pol2qm74 1190 9 alter alter VB cord-015021-pol2qm74 1190 10 the the DT cord-015021-pol2qm74 1190 11 threshold threshold NN cord-015021-pol2qm74 1190 12 concentration concentration NN cord-015021-pol2qm74 1190 13 of of IN cord-015021-pol2qm74 1190 14 FMLP FMLP NNP cord-015021-pol2qm74 1190 15 required require VBD cord-015021-pol2qm74 1190 16 to to TO cord-015021-pol2qm74 1190 17 induce induce VB cord-015021-pol2qm74 1190 18 shedding shed VBG cord-015021-pol2qm74 1190 19 , , , cord-015021-pol2qm74 1190 20 We -PRON- PRP cord-015021-pol2qm74 1190 21 conclude conclude VBP cord-015021-pol2qm74 1190 22 that that IN cord-015021-pol2qm74 1190 23 the the DT cord-015021-pol2qm74 1190 24 extent extent NN cord-015021-pol2qm74 1190 25 and and CC cord-015021-pol2qm74 1190 26 rapidity rapidity NN cord-015021-pol2qm74 1190 27 of of IN cord-015021-pol2qm74 1190 28 L L NNP cord-015021-pol2qm74 1190 29 - - HYPH cord-015021-pol2qm74 1190 30 selectin selectin NNP cord-015021-pol2qm74 1190 31 shedding shedding NN cord-015021-pol2qm74 1190 32 may may MD cord-015021-pol2qm74 1190 33 be be VB cord-015021-pol2qm74 1190 34 modified modify VBN cord-015021-pol2qm74 1190 35 by by IN cord-015021-pol2qm74 1190 36 different different JJ cord-015021-pol2qm74 1190 37 combinations combination NNS cord-015021-pol2qm74 1190 38 of of IN cord-015021-pol2qm74 1190 39 ligands ligand NNS cord-015021-pol2qm74 1190 40 and and CC cord-015021-pol2qm74 1190 41 that that IN cord-015021-pol2qm74 1190 42 shedding shedding NN cord-015021-pol2qm74 1190 43 , , , cord-015021-pol2qm74 1190 44 by by IN cord-015021-pol2qm74 1190 45 vidue vidue NNP cord-015021-pol2qm74 1190 46 of of IN cord-015021-pol2qm74 1190 47 the the DT cord-015021-pol2qm74 1190 48 high high JJ cord-015021-pol2qm74 1190 49 concentrations concentration NNS cord-015021-pol2qm74 1190 50 of of IN cord-015021-pol2qm74 1190 51 cytokines cytokine NNS cord-015021-pol2qm74 1190 52 or or CC cord-015021-pol2qm74 1190 53 chemotactic chemotactic JJ cord-015021-pol2qm74 1190 54 factors factor NNS cord-015021-pol2qm74 1190 55 required require VBN cord-015021-pol2qm74 1190 56 , , , cord-015021-pol2qm74 1190 57 is be VBZ cord-015021-pol2qm74 1190 58 a a DT cord-015021-pol2qm74 1190 59 process process NN cord-015021-pol2qm74 1190 60 localized localize VBN cord-015021-pol2qm74 1190 61 to to IN cord-015021-pol2qm74 1190 62 sites site NNS cord-015021-pol2qm74 1190 63 of of IN cord-015021-pol2qm74 1190 64 infection infection NN cord-015021-pol2qm74 1190 65 or or CC cord-015021-pol2qm74 1190 66 inflammation inflammation NN cord-015021-pol2qm74 1190 67 . . . cord-015021-pol2qm74 1191 1 We -PRON- PRP cord-015021-pol2qm74 1191 2 prospectively prospectively RB cord-015021-pol2qm74 1191 3 studied study VBD cord-015021-pol2qm74 1191 4 23 23 CD cord-015021-pol2qm74 1191 5 patients patient NNS cord-015021-pol2qm74 1191 6 with with IN cord-015021-pol2qm74 1191 7 severe severe JJ cord-015021-pol2qm74 1191 8 sepsis sepsis NN cord-015021-pol2qm74 1191 9 syndrome syndrome NN cord-015021-pol2qm74 1191 10 ; ; : cord-015021-pol2qm74 1191 11 Group Group NNP cord-015021-pol2qm74 1191 12 A A NNP cord-015021-pol2qm74 1191 13 : : : cord-015021-pol2qm74 1191 14 Septic septic JJ cord-015021-pol2qm74 1191 15 shock shock NN cord-015021-pol2qm74 1191 16 with with IN cord-015021-pol2qm74 1191 17 or or CC cord-015021-pol2qm74 1191 18 without without IN cord-015021-pol2qm74 1191 19 Adult Adult NNP cord-015021-pol2qm74 1191 20 Respiratory Respiratory NNP cord-015021-pol2qm74 1191 21 Distress Distress NNP cord-015021-pol2qm74 1191 22 Syndrome Syndrome NNP cord-015021-pol2qm74 1191 23 lARDS lards NN cord-015021-pol2qm74 1191 24 ) ) -RRB- cord-015021-pol2qm74 1192 1 ( ( -LRB- cord-015021-pol2qm74 1192 2 n n NN cord-015021-pol2qm74 1192 3 = = SYM cord-015021-pol2qm74 1192 4 7 7 CD cord-015021-pol2qm74 1192 5 , , , cord-015021-pol2qm74 1192 6 bacteremia bacteremia NN cord-015021-pol2qm74 1192 7 = = SYM cord-015021-pol2qm74 1192 8 6 6 CD cord-015021-pol2qm74 1192 9 ) ) -RRB- cord-015021-pol2qm74 1192 10 ; ; : cord-015021-pol2qm74 1192 11 Group Group NNP cord-015021-pol2qm74 1192 12 B B NNP cord-015021-pol2qm74 1192 13 : : : cord-015021-pol2qm74 1193 1 Sepsis sepsis NN cord-015021-pol2qm74 1193 2 syndrome syndrome NN cord-015021-pol2qm74 1193 3 without without IN cord-015021-pol2qm74 1193 4 septic septic JJ cord-015021-pol2qm74 1193 5 shock shock NN cord-015021-pol2qm74 1193 6 ( ( -LRB- cord-015021-pol2qm74 1193 7 n n NN cord-015021-pol2qm74 1193 8 = = SYM cord-015021-pol2qm74 1193 9 16 16 CD cord-015021-pol2qm74 1193 10 , , , cord-015021-pol2qm74 1193 11 bacteremia bacteremia NN cord-015021-pol2qm74 1193 12 = = SYM cord-015021-pol2qm74 1193 13 9 9 CD cord-015021-pol2qm74 1193 14 ) ) -RRB- cord-015021-pol2qm74 1193 15 . . . cord-015021-pol2qm74 1194 1 Serial serial JJ cord-015021-pol2qm74 1194 2 plasma plasma NN cord-015021-pol2qm74 1194 3 samples sample NNS cord-015021-pol2qm74 1194 4 obtained obtain VBN cord-015021-pol2qm74 1194 5 on on IN cord-015021-pol2qm74 1194 6 day day NN cord-015021-pol2qm74 1194 7 0 0 CD cord-015021-pol2qm74 1194 8 , , , cord-015021-pol2qm74 1194 9 1 1 CD cord-015021-pol2qm74 1194 10 , , , cord-015021-pol2qm74 1194 11 3 3 CD cord-015021-pol2qm74 1194 12 , , , cord-015021-pol2qm74 1194 13 6 6 CD cord-015021-pol2qm74 1194 14 , , , cord-015021-pol2qm74 1194 15 10 10 CD cord-015021-pol2qm74 1194 16 and and CC cord-015021-pol2qm74 1194 17 14 14 CD cord-015021-pol2qm74 1194 18 , , , cord-015021-pol2qm74 1194 19 were be VBD cord-015021-pol2qm74 1194 20 assayed assay VBN cord-015021-pol2qm74 1194 21 using use VBG cord-015021-pol2qm74 1194 22 ELISAs elisa NNS cord-015021-pol2qm74 1194 23 method method NN cord-015021-pol2qm74 1194 24 ( ( -LRB- cord-015021-pol2qm74 1194 25 British British NNP cord-015021-pol2qm74 1194 26 Biotechnology Biotechnology NNP cord-015021-pol2qm74 1194 27 ) ) -RRB- cord-015021-pol2qm74 1194 28 , , , cord-015021-pol2qm74 1194 29 Normal normal JJ cord-015021-pol2qm74 1194 30 control control NN cord-015021-pol2qm74 1194 31 levels level NNS cord-015021-pol2qm74 1194 32 of of IN cord-015021-pol2qm74 1194 33 soluble soluble JJ cord-015021-pol2qm74 1194 34 ICAM-1 icam-1 NN cord-015021-pol2qm74 1194 35 and and CC cord-015021-pol2qm74 1194 36 E E NNP cord-015021-pol2qm74 1194 37 - - NNP cord-015021-pol2qm74 1194 38 Selectin Selectin NNP cord-015021-pol2qm74 1194 39 , , , cord-015021-pol2qm74 1194 40 obtained obtain VBN cord-015021-pol2qm74 1194 41 from from IN cord-015021-pol2qm74 1194 42 11 11 CD cord-015021-pol2qm74 1194 43 healthy healthy JJ cord-015021-pol2qm74 1194 44 volunteers volunteer NNS cord-015021-pol2qm74 1194 45 , , , cord-015021-pol2qm74 1194 46 were be VBD cord-015021-pol2qm74 1194 47 respectively respectively RB cord-015021-pol2qm74 1194 48 205 205 CD cord-015021-pol2qm74 1194 49 ± ± CD cord-015021-pol2qm74 1194 50 19.4 19.4 CD cord-015021-pol2qm74 1194 51 ng ng NNP cord-015021-pol2qm74 1194 52 / / SYM cord-015021-pol2qm74 1194 53 ml ml NN cord-015021-pol2qm74 1194 54 and and CC cord-015021-pol2qm74 1194 55 45 45 CD cord-015021-pol2qm74 1194 56 ± ± CD cord-015021-pol2qm74 1194 57 5.7 5.7 CD cord-015021-pol2qm74 1194 58 ng ng NN cord-015021-pol2qm74 1194 59 / / SYM cord-015021-pol2qm74 1194 60 ml ml NN cord-015021-pol2qm74 1195 1 ( ( -LRB- cord-015021-pol2qm74 1195 2 mean mean VB cord-015021-pol2qm74 1195 3 _ _ NN cord-015021-pol2qm74 1195 4 + + CC cord-015021-pol2qm74 1195 5 SE SE NNP cord-015021-pol2qm74 1195 6 ) ) -RRB- cord-015021-pol2qm74 1195 7 , , , cord-015021-pol2qm74 1195 8 Acute acute JJ cord-015021-pol2qm74 1195 9 lung lung NN cord-015021-pol2qm74 1195 10 injury injury NN cord-015021-pol2qm74 1195 11 was be VBD cord-015021-pol2qm74 1195 12 quantified quantify VBN cord-015021-pol2qm74 1195 13 dally dally RB cord-015021-pol2qm74 1195 14 on on IN cord-015021-pol2qm74 1195 15 a a DT cord-015021-pol2qm74 1195 16 tour tour NN cord-015021-pol2qm74 1195 17 - - HYPH cord-015021-pol2qm74 1195 18 point point NN cord-015021-pol2qm74 1195 19 score score NN cord-015021-pol2qm74 1195 20 system system NN cord-015021-pol2qm74 1195 21 ( ( -LRB- cord-015021-pol2qm74 1195 22 Murray Murray NNP cord-015021-pol2qm74 1195 23 , , , cord-015021-pol2qm74 1195 24 Am Am NNP cord-015021-pol2qm74 1195 25 Rev Rev NNP cord-015021-pol2qm74 1195 26 Respir Respir NNP cord-015021-pol2qm74 1195 27 Dis,1989 dis,1989 CD cord-015021-pol2qm74 1195 28 ) ) -RRB- cord-015021-pol2qm74 1195 29 . . . cord-015021-pol2qm74 1196 1 Compared compare VBN cord-015021-pol2qm74 1196 2 to to TO cord-015021-pol2qm74 1196 3 control control VB cord-015021-pol2qm74 1196 4 mean mean JJ cord-015021-pol2qm74 1196 5 values value NNS cord-015021-pol2qm74 1196 6 , , , cord-015021-pol2qm74 1196 7 initial initial JJ cord-015021-pol2qm74 1196 8 levels level NNS cord-015021-pol2qm74 1196 9 of of IN cord-015021-pol2qm74 1196 10 groups group NNS cord-015021-pol2qm74 1196 11 A A NNP cord-015021-pol2qm74 1196 12 and and CC cord-015021-pol2qm74 1196 13 B B NNP cord-015021-pol2qm74 1196 14 were be VBD cord-015021-pol2qm74 1196 15 significantly significantly RB cord-015021-pol2qm74 1196 16 higher high JJR cord-015021-pol2qm74 1196 17 for for IN cord-015021-pol2qm74 1196 18 ICAM-1 icam-1 NN cord-015021-pol2qm74 1196 19 ( ( -LRB- cord-015021-pol2qm74 1196 20 p p NN cord-015021-pol2qm74 1196 21 < < XX cord-015021-pol2qm74 1196 22 10 10 CD cord-015021-pol2qm74 1196 23 -4 -4 CD cord-015021-pol2qm74 1196 24 ) ) -RRB- cord-015021-pol2qm74 1196 25 and and CC cord-015021-pol2qm74 1196 26 E E NNP cord-015021-pol2qm74 1196 27 - - NN cord-015021-pol2qm74 1196 28 Selectin Selectin NNP cord-015021-pol2qm74 1197 1 ( ( -LRB- cord-015021-pol2qm74 1197 2 p p NN cord-015021-pol2qm74 1197 3 < < XX cord-015021-pol2qm74 1197 4 10 10 CD cord-015021-pol2qm74 1197 5 - - SYM cord-015021-pol2qm74 1197 6 3 3 CD cord-015021-pol2qm74 1197 7 ) ) -RRB- cord-015021-pol2qm74 1197 8 . . . cord-015021-pol2qm74 1198 1 Comparisons comparison NNS cord-015021-pol2qm74 1198 2 of of IN cord-015021-pol2qm74 1198 3 group group NN cord-015021-pol2qm74 1198 4 A a NN cord-015021-pol2qm74 1199 1 and and CC cord-015021-pol2qm74 1199 2 [ [ -LRB- cord-015021-pol2qm74 1199 3 ] ] -RRB- cord-015021-pol2qm74 1200 1 ( ( -LRB- cord-015021-pol2qm74 1200 2 * * NFP cord-015021-pol2qm74 1200 3 = = SYM cord-015021-pol2qm74 1200 4 p<0.05 p<0.05 CD cord-015021-pol2qm74 1201 1 ; ; : cord-015021-pol2qm74 1202 1 * * NFP cord-015021-pol2qm74 1202 2 * * NFP cord-015021-pol2qm74 1202 3 = = NFP cord-015021-pol2qm74 1203 1 p<0.00 p<0.00 JJ cord-015021-pol2qm74 1204 1 t t NNP cord-015021-pol2qm74 1204 2 ) ) -RRB- cord-015021-pol2qm74 1205 1 Soluble soluble JJ cord-015021-pol2qm74 1205 2 ICAM-1 icam-1 NN cord-015021-pol2qm74 1205 3 levels level NNS cord-015021-pol2qm74 1205 4 of of IN cord-015021-pol2qm74 1205 5 group group NN cord-015021-pol2qm74 1205 6 A a NN cord-015021-pol2qm74 1206 1 enhanced enhance VBN cord-015021-pol2qm74 1206 2 significantly significantly RB cord-015021-pol2qm74 1206 3 ( ( -LRB- cord-015021-pol2qm74 1206 4 p<0.05 p<0.05 CD cord-015021-pol2qm74 1206 5 ) ) -RRB- cord-015021-pol2qm74 1207 1 during during IN cord-015021-pol2qm74 1207 2 the the DT cord-015021-pol2qm74 1207 3 first first JJ cord-015021-pol2qm74 1207 4 24 24 CD cord-015021-pol2qm74 1207 5 hours hour NNS cord-015021-pol2qm74 1207 6 , , , cord-015021-pol2qm74 1207 7 and and CC cord-015021-pol2qm74 1207 8 a a DT cord-015021-pol2qm74 1207 9 sustained sustained JJ cord-015021-pol2qm74 1207 10 high high JJ cord-015021-pol2qm74 1207 11 levels level NNS cord-015021-pol2qm74 1207 12 was be VBD cord-015021-pol2qm74 1207 13 of of IN cord-015021-pol2qm74 1207 14 bad bad JJ cord-015021-pol2qm74 1207 15 prognosis prognosis NN cord-015021-pol2qm74 1207 16 ( ( -LRB- cord-015021-pol2qm74 1207 17 25 25 CD cord-015021-pol2qm74 1207 18 % % NN cord-015021-pol2qm74 1207 19 of of IN cord-015021-pol2qm74 1207 20 survivors survivor NNS cord-015021-pol2qm74 1207 21 at at IN cord-015021-pol2qm74 1207 22 day day NN cord-015021-pol2qm74 1207 23 6 6 CD cord-015021-pol2qm74 1207 24 ) ) -RRB- cord-015021-pol2qm74 1207 25 . . . cord-015021-pol2qm74 1208 1 The the DT cord-015021-pol2qm74 1208 2 evolution evolution NN cord-015021-pol2qm74 1208 3 of of IN cord-015021-pol2qm74 1208 4 soluble soluble JJ cord-015021-pol2qm74 1208 5 ICAM-1 icam-1 NN cord-015021-pol2qm74 1208 6 and and CC cord-015021-pol2qm74 1208 7 E E NNP cord-015021-pol2qm74 1208 8 - - HYPH cord-015021-pol2qm74 1208 9 Selectin Selectin NNP cord-015021-pol2qm74 1208 10 levels level NNS cord-015021-pol2qm74 1208 11 were be VBD cord-015021-pol2qm74 1208 12 significantly significantly RB cord-015021-pol2qm74 1208 13 correlated correlate VBN cord-015021-pol2qm74 1208 14 with with IN cord-015021-pol2qm74 1208 15 Murray Murray NNP cord-015021-pol2qm74 1208 16 's 's POS cord-015021-pol2qm74 1208 17 score score NN cord-015021-pol2qm74 1208 18 ( ( -LRB- cord-015021-pol2qm74 1208 19 Spearman Spearman NNP cord-015021-pol2qm74 1208 20 test test NN cord-015021-pol2qm74 1208 21 : : : cord-015021-pol2qm74 1208 22 p p NN cord-015021-pol2qm74 1208 23 < < XX cord-015021-pol2qm74 1208 24 0.001 0.001 CD cord-015021-pol2qm74 1208 25 ) ) -RRB- cord-015021-pol2qm74 1208 26 . . . cord-015021-pol2qm74 1209 1 Conclusion conclusion NN cord-015021-pol2qm74 1209 2 : : : cord-015021-pol2qm74 1210 1 These these DT cord-015021-pol2qm74 1210 2 results result NNS cord-015021-pol2qm74 1210 3 suggest suggest VBP cord-015021-pol2qm74 1210 4 that that IN cord-015021-pol2qm74 1210 5 endothelial endothelial JJ cord-015021-pol2qm74 1210 6 adhesion adhesion NN cord-015021-pol2qm74 1210 7 molecules molecule NNS cord-015021-pol2qm74 1210 8 are be VBP cord-015021-pol2qm74 1210 9 released release VBN cord-015021-pol2qm74 1210 10 into into IN cord-015021-pol2qm74 1210 11 the the DT cord-015021-pol2qm74 1210 12 plasma plasma NN cord-015021-pol2qm74 1210 13 of of IN cord-015021-pol2qm74 1210 14 patients patient NNS cord-015021-pol2qm74 1210 15 with with IN cord-015021-pol2qm74 1210 16 severe severe JJ cord-015021-pol2qm74 1210 17 sepsis sepsis NN cord-015021-pol2qm74 1210 18 syndrome syndrome NN cord-015021-pol2qm74 1210 19 . . . cord-015021-pol2qm74 1211 1 Soluble soluble JJ cord-015021-pol2qm74 1211 2 ICAM-1 icam-1 NN cord-015021-pol2qm74 1211 3 and and CC cord-015021-pol2qm74 1211 4 E E NNP cord-015021-pol2qm74 1211 5 - - : cord-015021-pol2qm74 1211 6 Selectin Selectin NNP cord-015021-pol2qm74 1211 7 are be VBP cord-015021-pol2qm74 1211 8 correlated correlate VBN cord-015021-pol2qm74 1211 9 with with IN cord-015021-pol2qm74 1211 10 endothelial endothelial JJ cord-015021-pol2qm74 1211 11 lung lung NN cord-015021-pol2qm74 1211 12 damage damage NN cord-015021-pol2qm74 1211 13 , , , cord-015021-pol2qm74 1211 14 and and CC cord-015021-pol2qm74 1211 15 lOAM-1 loam-1 NN cord-015021-pol2qm74 1211 16 seems seem VBZ cord-015021-pol2qm74 1211 17 to to TO cord-015021-pol2qm74 1211 18 be be VB cord-015021-pol2qm74 1211 19 a a DT cord-015021-pol2qm74 1211 20 better well JJR cord-015021-pol2qm74 1211 21 indicator indicator NN cord-015021-pol2qm74 1211 22 of of IN cord-015021-pol2qm74 1211 23 the the DT cord-015021-pol2qm74 1211 24 severity severity NN cord-015021-pol2qm74 1211 25 of of IN cord-015021-pol2qm74 1211 26 endothelial endothelial JJ cord-015021-pol2qm74 1211 27 injury injury NN cord-015021-pol2qm74 1211 28 . . . cord-015021-pol2qm74 1211 29 _SP cord-015021-pol2qm74 1212 1 Introductory introductory JJ cord-015021-pol2qm74 1212 2 remarks remark VBZ cord-015021-pol2qm74 1212 3 to to IN cord-015021-pol2qm74 1212 4 anti anti JJ cord-015021-pol2qm74 1212 5 - - JJ cord-015021-pol2qm74 1212 6 adhesion adhesion JJ cord-015021-pol2qm74 1212 7 molecule molecule NN cord-015021-pol2qm74 1212 8 strategies strategy NNS cord-015021-pol2qm74 1212 9 as as IN cord-015021-pol2qm74 1212 10 a a DT cord-015021-pol2qm74 1212 11 therapeutic therapeutic JJ cord-015021-pol2qm74 1212 12 modality modality NN cord-015021-pol2qm74 1212 13 CH CH NNP cord-015021-pol2qm74 1212 14 Wortel Wortel NNP cord-015021-pol2qm74 1212 15 , , , cord-015021-pol2qm74 1212 16 Repligen Repligen NNP cord-015021-pol2qm74 1212 17 Corporation Corporation NNP cord-015021-pol2qm74 1212 18 , , , cord-015021-pol2qm74 1212 19 One one CD cord-015021-pol2qm74 1212 20 Kendall Kendall NNP cord-015021-pol2qm74 1212 21 Square Square NNP cord-015021-pol2qm74 1212 22 , , , cord-015021-pol2qm74 1212 23 Building Building NNP cord-015021-pol2qm74 1212 24 700 700 CD cord-015021-pol2qm74 1212 25 , , , cord-015021-pol2qm74 1212 26 Cambridge Cambridge NNP cord-015021-pol2qm74 1212 27 , , , cord-015021-pol2qm74 1212 28 MA MA NNP cord-015021-pol2qm74 1212 29 02139 02139 CD cord-015021-pol2qm74 1212 30 , , , cord-015021-pol2qm74 1212 31 USA USA NNP cord-015021-pol2qm74 1212 32 . . . cord-015021-pol2qm74 1213 1 The the DT cord-015021-pol2qm74 1213 2 development development NN cord-015021-pol2qm74 1213 3 of of IN cord-015021-pol2qm74 1213 4 antimicrobial antimicrobial JJ cord-015021-pol2qm74 1213 5 therapy therapy NN cord-015021-pol2qm74 1213 6 represented represent VBD cord-015021-pol2qm74 1213 7 a a DT cord-015021-pol2qm74 1213 8 major major JJ cord-015021-pol2qm74 1213 9 breakthrough breakthrough NN cord-015021-pol2qm74 1213 10 in in IN cord-015021-pol2qm74 1213 11 the the DT cord-015021-pol2qm74 1213 12 struggle struggle NN cord-015021-pol2qm74 1213 13 against against IN cord-015021-pol2qm74 1213 14 disease disease NN cord-015021-pol2qm74 1213 15 . . . cord-015021-pol2qm74 1214 1 It -PRON- PRP cord-015021-pol2qm74 1214 2 strengthened strengthen VBD cord-015021-pol2qm74 1214 3 the the DT cord-015021-pol2qm74 1214 4 notion notion NN cord-015021-pol2qm74 1214 5 that that IN cord-015021-pol2qm74 1214 6 disease disease NN cord-015021-pol2qm74 1214 7 could could MD cord-015021-pol2qm74 1214 8 be be VB cord-015021-pol2qm74 1214 9 overcome overcome VBN cord-015021-pol2qm74 1214 10 by by IN cord-015021-pol2qm74 1214 11 eliminating eliminate VBG cord-015021-pol2qm74 1214 12 foreign foreign JJ cord-015021-pol2qm74 1214 13 invaders invader NNS cord-015021-pol2qm74 1214 14 threatening threaten VBG cord-015021-pol2qm74 1214 15 the the DT cord-015021-pol2qm74 1214 16 host host NN cord-015021-pol2qm74 1214 17 . . . cord-015021-pol2qm74 1215 1 This this DT cord-015021-pol2qm74 1215 2 paradigm paradigm NN cord-015021-pol2qm74 1215 3 has have VBZ cord-015021-pol2qm74 1215 4 proven prove VBN cord-015021-pol2qm74 1215 5 to to TO cord-015021-pol2qm74 1215 6 be be VB cord-015021-pol2qm74 1215 7 very very RB cord-015021-pol2qm74 1215 8 successful successful JJ cord-015021-pol2qm74 1215 9 , , , cord-015021-pol2qm74 1215 10 the the DT cord-015021-pol2qm74 1215 11 threat threat NN cord-015021-pol2qm74 1215 12 of of IN cord-015021-pol2qm74 1215 13 many many JJ cord-015021-pol2qm74 1215 14 infectious infectious JJ cord-015021-pol2qm74 1215 15 diseases disease NNS cord-015021-pol2qm74 1215 16 has have VBZ cord-015021-pol2qm74 1215 17 significantly significantly RB cord-015021-pol2qm74 1215 18 changed change VBN cord-015021-pol2qm74 1215 19 , , , cord-015021-pol2qm74 1215 20 some some DT cord-015021-pol2qm74 1215 21 have have VBP cord-015021-pol2qm74 1215 22 even even RB cord-015021-pol2qm74 1215 23 been be VBN cord-015021-pol2qm74 1215 24 eradicated eradicate VBN cord-015021-pol2qm74 1215 25 . . . cord-015021-pol2qm74 1216 1 Nevertheless nevertheless RB cord-015021-pol2qm74 1216 2 , , , cord-015021-pol2qm74 1216 3 sepsis sepsis NN cord-015021-pol2qm74 1216 4 has have VBZ cord-015021-pol2qm74 1216 5 remained remain VBN cord-015021-pol2qm74 1216 6 a a DT cord-015021-pol2qm74 1216 7 severe severe JJ cord-015021-pol2qm74 1216 8 condition condition NN cord-015021-pol2qm74 1216 9 , , , cord-015021-pol2qm74 1216 10 increasing increase VBG cord-015021-pol2qm74 1216 11 in in IN cord-015021-pol2qm74 1216 12 incidence incidence NN cord-015021-pol2qm74 1216 13 while while IN cord-015021-pol2qm74 1216 14 mortality mortality NN cord-015021-pol2qm74 1216 15 remained remain VBD cord-015021-pol2qm74 1216 16 very very RB cord-015021-pol2qm74 1216 17 high high JJ cord-015021-pol2qm74 1216 18 . . . cord-015021-pol2qm74 1217 1 More more RBR cord-015021-pol2qm74 1217 2 recently recently RB cord-015021-pol2qm74 1217 3 , , , cord-015021-pol2qm74 1217 4 it -PRON- PRP cord-015021-pol2qm74 1217 5 has have VBZ cord-015021-pol2qm74 1217 6 become become VBN cord-015021-pol2qm74 1217 7 increasingly increasingly RB cord-015021-pol2qm74 1217 8 clear clear JJ cord-015021-pol2qm74 1217 9 that that IN cord-015021-pol2qm74 1217 10 besides besides IN cord-015021-pol2qm74 1217 11 the the DT cord-015021-pol2qm74 1217 12 nature nature NN cord-015021-pol2qm74 1217 13 and and CC cord-015021-pol2qm74 1217 14 treatment treatment NN cord-015021-pol2qm74 1217 15 of of IN cord-015021-pol2qm74 1217 16 an an DT cord-015021-pol2qm74 1217 17 exogenous exogenous JJ cord-015021-pol2qm74 1217 18 agent agent NN cord-015021-pol2qm74 1217 19 , , , cord-015021-pol2qm74 1217 20 the the DT cord-015021-pol2qm74 1217 21 reaction reaction NN cord-015021-pol2qm74 1217 22 of of IN cord-015021-pol2qm74 1217 23 the the DT cord-015021-pol2qm74 1217 24 host host NN cord-015021-pol2qm74 1217 25 defense defense NN cord-015021-pol2qm74 1217 26 itself -PRON- PRP cord-015021-pol2qm74 1217 27 plays play VBZ cord-015021-pol2qm74 1217 28 a a DT cord-015021-pol2qm74 1217 29 pivotal pivotal JJ cord-015021-pol2qm74 1217 30 role role NN cord-015021-pol2qm74 1217 31 in in IN cord-015021-pol2qm74 1217 32 the the DT cord-015021-pol2qm74 1217 33 outcome outcome NN cord-015021-pol2qm74 1217 34 of of IN cord-015021-pol2qm74 1217 35 the the DT cord-015021-pol2qm74 1217 36 event event NN cord-015021-pol2qm74 1217 37 . . . cord-015021-pol2qm74 1218 1 Endogenous endogenous JJ cord-015021-pol2qm74 1218 2 mediators mediator NNS cord-015021-pol2qm74 1218 3 , , , cord-015021-pol2qm74 1218 4 such such JJ cord-015021-pol2qm74 1218 5 as as IN cord-015021-pol2qm74 1218 6 TNF TNF NNP cord-015021-pol2qm74 1218 7 , , , cord-015021-pol2qm74 1218 8 IL IL NNP cord-015021-pol2qm74 1218 9 - - HYPH cord-015021-pol2qm74 1218 10 I I NNP cord-015021-pol2qm74 1218 11 , , , cord-015021-pol2qm74 1218 12 IL-6 IL-6 NNP cord-015021-pol2qm74 1218 13 and and CC cord-015021-pol2qm74 1218 14 IL-8 IL-8 NNP cord-015021-pol2qm74 1218 15 , , , cord-015021-pol2qm74 1218 16 govem govem JJ cord-015021-pol2qm74 1218 17 many many JJ cord-015021-pol2qm74 1218 18 of of IN cord-015021-pol2qm74 1218 19 the the DT cord-015021-pol2qm74 1218 20 actions action NNS cord-015021-pol2qm74 1218 21 of of IN cord-015021-pol2qm74 1218 22 the the DT cord-015021-pol2qm74 1218 23 host host NN cord-015021-pol2qm74 1218 24 defense defense NN cord-015021-pol2qm74 1218 25 system system NN cord-015021-pol2qm74 1218 26 . . . cord-015021-pol2qm74 1219 1 While while IN cord-015021-pol2qm74 1219 2 the the DT cord-015021-pol2qm74 1219 3 expression expression NN cord-015021-pol2qm74 1219 4 of of IN cord-015021-pol2qm74 1219 5 these these DT cord-015021-pol2qm74 1219 6 cytokines cytokine NNS cord-015021-pol2qm74 1219 7 more more RBR cord-015021-pol2qm74 1219 8 often often RB cord-015021-pol2qm74 1219 9 than than IN cord-015021-pol2qm74 1219 10 not not RB cord-015021-pol2qm74 1219 11 benefit benefit VB cord-015021-pol2qm74 1219 12 the the DT cord-015021-pol2qm74 1219 13 host host NN cord-015021-pol2qm74 1219 14 , , , cord-015021-pol2qm74 1219 15 ( ( -LRB- cord-015021-pol2qm74 1219 16 over)-expression over)-expression NN cord-015021-pol2qm74 1219 17 can can MD cord-015021-pol2qm74 1219 18 cause cause VB cord-015021-pol2qm74 1219 19 severe severe JJ cord-015021-pol2qm74 1219 20 damage damage NN cord-015021-pol2qm74 1219 21 . . . cord-015021-pol2qm74 1220 1 Based base VBN cord-015021-pol2qm74 1220 2 on on IN cord-015021-pol2qm74 1220 3 this this DT cord-015021-pol2qm74 1220 4 hypothesis hypothesis NN cord-015021-pol2qm74 1220 5 , , , cord-015021-pol2qm74 1220 6 anticytokine anticytokine JJ cord-015021-pol2qm74 1220 7 strategies strategy NNS cord-015021-pol2qm74 1220 8 , , , cord-015021-pol2qm74 1220 9 such such JJ cord-015021-pol2qm74 1220 10 as as IN cord-015021-pol2qm74 1220 11 those those DT cord-015021-pol2qm74 1220 12 targeted target VBN cord-015021-pol2qm74 1220 13 against against IN cord-015021-pol2qm74 1220 14 TNF TNF NNP cord-015021-pol2qm74 1220 15 or or CC cord-015021-pol2qm74 1220 16 IL-1 IL-1 NNP cord-015021-pol2qm74 1220 17 , , , cord-015021-pol2qm74 1220 18 have have VBP cord-015021-pol2qm74 1220 19 been be VBN cord-015021-pol2qm74 1220 20 evaluated evaluate VBN cord-015021-pol2qm74 1220 21 for for IN cord-015021-pol2qm74 1220 22 the the DT cord-015021-pol2qm74 1220 23 treatment treatment NN cord-015021-pol2qm74 1220 24 of of IN cord-015021-pol2qm74 1220 25 sepsis sepsis NN cord-015021-pol2qm74 1220 26 . . . cord-015021-pol2qm74 1221 1 Results result NNS cord-015021-pol2qm74 1221 2 of of IN cord-015021-pol2qm74 1221 3 these these DT cord-015021-pol2qm74 1221 4 early early JJ cord-015021-pol2qm74 1221 5 studies study NNS cord-015021-pol2qm74 1221 6 have have VBP cord-015021-pol2qm74 1221 7 not not RB cord-015021-pol2qm74 1221 8 yet yet RB cord-015021-pol2qm74 1221 9 indicated indicate VBN cord-015021-pol2qm74 1221 10 success success NN cord-015021-pol2qm74 1221 11 in in IN cord-015021-pol2qm74 1221 12 improving improve VBG cord-015021-pol2qm74 1221 13 the the DT cord-015021-pol2qm74 1221 14 outcome outcome NN cord-015021-pol2qm74 1221 15 of of IN cord-015021-pol2qm74 1221 16 the the DT cord-015021-pol2qm74 1221 17 disease disease NN cord-015021-pol2qm74 1221 18 . . . cord-015021-pol2qm74 1222 1 It -PRON- PRP cord-015021-pol2qm74 1222 2 has have VBZ cord-015021-pol2qm74 1222 3 been be VBN cord-015021-pol2qm74 1222 4 difficult difficult JJ cord-015021-pol2qm74 1222 5 to to TO cord-015021-pol2qm74 1222 6 define define VB cord-015021-pol2qm74 1222 7 a a DT cord-015021-pol2qm74 1222 8 patient patient JJ cord-015021-pol2qm74 1222 9 population population NN cord-015021-pol2qm74 1222 10 where where WRB cord-015021-pol2qm74 1222 11 a a DT cord-015021-pol2qm74 1222 12 benefit benefit NN cord-015021-pol2qm74 1222 13 could could MD cord-015021-pol2qm74 1222 14 be be VB cord-015021-pol2qm74 1222 15 reproducibly reproducibly RB cord-015021-pol2qm74 1222 16 shown show VBN cord-015021-pol2qm74 1222 17 . . . cord-015021-pol2qm74 1223 1 Furthermore furthermore RB cord-015021-pol2qm74 1223 2 , , , cord-015021-pol2qm74 1223 3 it -PRON- PRP cord-015021-pol2qm74 1223 4 has have VBZ cord-015021-pol2qm74 1223 5 been be VBN cord-015021-pol2qm74 1223 6 documented document VBN cord-015021-pol2qm74 1223 7 that that IN cord-015021-pol2qm74 1223 8 synergy synergy NN cord-015021-pol2qm74 1223 9 between between IN cord-015021-pol2qm74 1223 10 cytokines cytokine NNS cord-015021-pol2qm74 1223 11 occurs occur VBZ cord-015021-pol2qm74 1223 12 , , , cord-015021-pol2qm74 1223 13 but but CC cord-015021-pol2qm74 1223 14 detailed detailed JJ cord-015021-pol2qm74 1223 15 knowledge knowledge NN cord-015021-pol2qm74 1223 16 of of IN cord-015021-pol2qm74 1223 17 the the DT cord-015021-pol2qm74 1223 18 cytokine cytokine NN cord-015021-pol2qm74 1223 19 network network NN cord-015021-pol2qm74 1223 20 is be VBZ cord-015021-pol2qm74 1223 21 not not RB cord-015021-pol2qm74 1223 22 yet yet RB cord-015021-pol2qm74 1223 23 available available JJ cord-015021-pol2qm74 1223 24 . . . cord-015021-pol2qm74 1224 1 It -PRON- PRP cord-015021-pol2qm74 1224 2 is be VBZ cord-015021-pol2qm74 1224 3 conceivable conceivable JJ cord-015021-pol2qm74 1224 4 , , , cord-015021-pol2qm74 1224 5 that that DT cord-015021-pol2qm74 1224 6 neutralization neutralization NN cord-015021-pol2qm74 1224 7 of of IN cord-015021-pol2qm74 1224 8 one one CD cord-015021-pol2qm74 1224 9 cytokine cytokine NN cord-015021-pol2qm74 1224 10 prompts prompt VBZ cord-015021-pol2qm74 1224 11 the the DT cord-015021-pol2qm74 1224 12 induction induction NN cord-015021-pol2qm74 1224 13 of of IN cord-015021-pol2qm74 1224 14 another another DT cord-015021-pol2qm74 1224 15 which which WDT cord-015021-pol2qm74 1224 16 will will MD cord-015021-pol2qm74 1224 17 evoke evoke VB cord-015021-pol2qm74 1224 18 the the DT cord-015021-pol2qm74 1224 19 intended intended JJ cord-015021-pol2qm74 1224 20 response response NN cord-015021-pol2qm74 1224 21 in in IN cord-015021-pol2qm74 1224 22 the the DT cord-015021-pol2qm74 1224 23 host host NN cord-015021-pol2qm74 1224 24 . . . cord-015021-pol2qm74 1225 1 Recent recent JJ cord-015021-pol2qm74 1225 2 data datum NNS cord-015021-pol2qm74 1225 3 obtained obtain VBN cord-015021-pol2qm74 1225 4 in in IN cord-015021-pol2qm74 1225 5 human human JJ cord-015021-pol2qm74 1225 6 endotoxemic endotoxemic JJ cord-015021-pol2qm74 1225 7 volunteer volunteer NN cord-015021-pol2qm74 1225 8 models model NNS cord-015021-pol2qm74 1225 9 seem seem VBP cord-015021-pol2qm74 1225 10 to to TO cord-015021-pol2qm74 1225 11 confirm confirm VB cord-015021-pol2qm74 1225 12 this this DT cord-015021-pol2qm74 1225 13 . . . cord-015021-pol2qm74 1226 1 If if IN cord-015021-pol2qm74 1226 2 this this DT cord-015021-pol2qm74 1226 3 turns turn VBZ cord-015021-pol2qm74 1226 4 out out RP cord-015021-pol2qm74 1226 5 to to TO cord-015021-pol2qm74 1226 6 be be VB cord-015021-pol2qm74 1226 7 the the DT cord-015021-pol2qm74 1226 8 case case NN cord-015021-pol2qm74 1226 9 , , , cord-015021-pol2qm74 1226 10 neutralizing neutralize VBG cord-015021-pol2qm74 1226 11 a a DT cord-015021-pol2qm74 1226 12 single single JJ cord-015021-pol2qm74 1226 13 cytokine cytokine NN cord-015021-pol2qm74 1226 14 may may MD cord-015021-pol2qm74 1226 15 not not RB cord-015021-pol2qm74 1226 16 be be VB cord-015021-pol2qm74 1226 17 a a DT cord-015021-pol2qm74 1226 18 successful successful JJ cord-015021-pol2qm74 1226 19 approach approach NN cord-015021-pol2qm74 1226 20 . . . cord-015021-pol2qm74 1227 1 Cytokines cytokine NNS cord-015021-pol2qm74 1227 2 in in IN cord-015021-pol2qm74 1227 3 tum tum NNP cord-015021-pol2qm74 1227 4 , , , cord-015021-pol2qm74 1227 5 induce induce VB cord-015021-pol2qm74 1227 6 various various JJ cord-015021-pol2qm74 1227 7 adhesion adhesion NN cord-015021-pol2qm74 1227 8 molecules molecule NNS cord-015021-pol2qm74 1227 9 , , , cord-015021-pol2qm74 1227 10 such such JJ cord-015021-pol2qm74 1227 11 as as IN cord-015021-pol2qm74 1227 12 ICAM-1 ICAM-1 NNP cord-015021-pol2qm74 1227 13 . . . cord-015021-pol2qm74 1228 1 Such such JJ cord-015021-pol2qm74 1228 2 molecules molecule NNS cord-015021-pol2qm74 1228 3 regulate regulate VBP cord-015021-pol2qm74 1228 4 for for IN cord-015021-pol2qm74 1228 5 instance instance NN cord-015021-pol2qm74 1228 6 the the DT cord-015021-pol2qm74 1228 7 neutrophil neutrophil NN cord-015021-pol2qm74 1228 8 - - HYPH cord-015021-pol2qm74 1228 9 endothelial endothelial JJ cord-015021-pol2qm74 1228 10 cell cell NN cord-015021-pol2qm74 1228 11 interactions interaction NNS cord-015021-pol2qm74 1228 12 , , , cord-015021-pol2qm74 1228 13 which which WDT cord-015021-pol2qm74 1228 14 are be VBP cord-015021-pol2qm74 1228 15 thought think VBN cord-015021-pol2qm74 1228 16 to to TO cord-015021-pol2qm74 1228 17 play play VB cord-015021-pol2qm74 1228 18 an an DT cord-015021-pol2qm74 1228 19 important important JJ cord-015021-pol2qm74 1228 20 role role NN cord-015021-pol2qm74 1228 21 in in IN cord-015021-pol2qm74 1228 22 the the DT cord-015021-pol2qm74 1228 23 pathogenesis pathogenesis NN cord-015021-pol2qm74 1228 24 of of IN cord-015021-pol2qm74 1228 25 systemic systemic JJ cord-015021-pol2qm74 1228 26 organ organ NN cord-015021-pol2qm74 1228 27 injury injury NN cord-015021-pol2qm74 1228 28 . . . cord-015021-pol2qm74 1229 1 The the DT cord-015021-pol2qm74 1229 2 potential potential NN cord-015021-pol2qm74 1229 3 for for IN cord-015021-pol2qm74 1229 4 monoclonal monoclonal JJ cord-015021-pol2qm74 1229 5 antibodies antibody NNS cord-015021-pol2qm74 1229 6 to to TO cord-015021-pol2qm74 1229 7 adhesion adhesion NN cord-015021-pol2qm74 1229 8 proteins protein NNS cord-015021-pol2qm74 1229 9 to to TO cord-015021-pol2qm74 1229 10 reduce reduce VB cord-015021-pol2qm74 1229 11 vascular vascular JJ cord-015021-pol2qm74 1229 12 and and CC cord-015021-pol2qm74 1229 13 tissue tissue NN cord-015021-pol2qm74 1229 14 damage damage NN cord-015021-pol2qm74 1229 15 has have VBZ cord-015021-pol2qm74 1229 16 been be VBN cord-015021-pol2qm74 1229 17 studied study VBN cord-015021-pol2qm74 1229 18 in in IN cord-015021-pol2qm74 1229 19 a a DT cord-015021-pol2qm74 1229 20 large large JJ cord-015021-pol2qm74 1229 21 number number NN cord-015021-pol2qm74 1229 22 of of IN cord-015021-pol2qm74 1229 23 experimental experimental JJ cord-015021-pol2qm74 1229 24 models model NNS cord-015021-pol2qm74 1229 25 . . . cord-015021-pol2qm74 1230 1 Protective protective JJ cord-015021-pol2qm74 1230 2 effects effect NNS cord-015021-pol2qm74 1230 3 have have VBP cord-015021-pol2qm74 1230 4 been be VBN cord-015021-pol2qm74 1230 5 observed observe VBN cord-015021-pol2qm74 1230 6 in in IN cord-015021-pol2qm74 1230 7 a a DT cord-015021-pol2qm74 1230 8 wide wide JJ cord-015021-pol2qm74 1230 9 variety variety NN cord-015021-pol2qm74 1230 10 of of IN cord-015021-pol2qm74 1230 11 inflammatory inflammatory JJ cord-015021-pol2qm74 1230 12 , , , cord-015021-pol2qm74 1230 13 immune immune JJ cord-015021-pol2qm74 1230 14 , , , cord-015021-pol2qm74 1230 15 and and CC cord-015021-pol2qm74 1230 16 ischemia ischemia NN cord-015021-pol2qm74 1230 17 - - HYPH cord-015021-pol2qm74 1230 18 reperfusion reperfusion NN cord-015021-pol2qm74 1230 19 injuries injury NNS cord-015021-pol2qm74 1230 20 . . . cord-015021-pol2qm74 1231 1 Thus thus RB cord-015021-pol2qm74 1231 2 , , , cord-015021-pol2qm74 1231 3 altering alter VBG cord-015021-pol2qm74 1231 4 the the DT cord-015021-pol2qm74 1231 5 host host NN cord-015021-pol2qm74 1231 6 response response NN cord-015021-pol2qm74 1231 7 by by IN cord-015021-pol2qm74 1231 8 modulating modulate VBG cord-015021-pol2qm74 1231 9 the the DT cord-015021-pol2qm74 1231 10 function function NN cord-015021-pol2qm74 1231 11 of of IN cord-015021-pol2qm74 1231 12 adhesion adhesion NN cord-015021-pol2qm74 1231 13 molecules molecule NNS cord-015021-pol2qm74 1231 14 may may MD cord-015021-pol2qm74 1231 15 attenuate attenuate VB cord-015021-pol2qm74 1231 16 the the DT cord-015021-pol2qm74 1231 17 inadvertent inadvertent JJ cord-015021-pol2qm74 1231 18 injury injury NN cord-015021-pol2qm74 1231 19 caused cause VBN cord-015021-pol2qm74 1231 20 by by IN cord-015021-pol2qm74 1231 21 inappropriate inappropriate JJ cord-015021-pol2qm74 1231 22 behavior behavior NN cord-015021-pol2qm74 1231 23 of of IN cord-015021-pol2qm74 1231 24 host host NN cord-015021-pol2qm74 1231 25 defense defense NN cord-015021-pol2qm74 1231 26 cells cell NNS cord-015021-pol2qm74 1231 27 . . . cord-015021-pol2qm74 1232 1 Targeting target VBG cord-015021-pol2qm74 1232 2 cellular cellular JJ cord-015021-pol2qm74 1232 3 surface surface NN cord-015021-pol2qm74 1232 4 interactions interaction NNS cord-015021-pol2qm74 1232 5 has have VBZ cord-015021-pol2qm74 1232 6 been be VBN cord-015021-pol2qm74 1232 7 added add VBN cord-015021-pol2qm74 1232 8 to to IN cord-015021-pol2qm74 1232 9 the the DT cord-015021-pol2qm74 1232 10 efforts effort NNS cord-015021-pol2qm74 1232 11 to to TO cord-015021-pol2qm74 1232 12 change change VB cord-015021-pol2qm74 1232 13 the the DT cord-015021-pol2qm74 1232 14 outcome outcome NN cord-015021-pol2qm74 1232 15 of of IN cord-015021-pol2qm74 1232 16 disease disease NN cord-015021-pol2qm74 1232 17 . . . cord-015021-pol2qm74 1233 1 Modulation modulation NN cord-015021-pol2qm74 1233 2 oftheseprocesses oftheseprocesse NNS cord-015021-pol2qm74 1233 3 seems seem VBZ cord-015021-pol2qm74 1233 4 very very RB cord-015021-pol2qm74 1233 5 promising promising JJ cord-015021-pol2qm74 1233 6 , , , cord-015021-pol2qm74 1233 7 but but CC cord-015021-pol2qm74 1233 8 may may MD cord-015021-pol2qm74 1233 9 temporarily temporarily RB cord-015021-pol2qm74 1233 10 leave leave VB cord-015021-pol2qm74 1233 11 the the DT cord-015021-pol2qm74 1233 12 host host NN cord-015021-pol2qm74 1233 13 without without IN cord-015021-pol2qm74 1233 14 effective effective JJ cord-015021-pol2qm74 1233 15 defense defense NN cord-015021-pol2qm74 1233 16 mechanism mechanism NN cord-015021-pol2qm74 1233 17 . . . cord-015021-pol2qm74 1234 1 Great great JJ cord-015021-pol2qm74 1234 2 care care NN cord-015021-pol2qm74 1234 3 therefore therefore RB cord-015021-pol2qm74 1234 4 , , , cord-015021-pol2qm74 1234 5 must must MD cord-015021-pol2qm74 1234 6 be be VB cord-015021-pol2qm74 1234 7 exerted exert VBN cord-015021-pol2qm74 1234 8 when when WRB cord-015021-pol2qm74 1234 9 studying study VBG cord-015021-pol2qm74 1234 10 this this DT cord-015021-pol2qm74 1234 11 powerful powerful JJ cord-015021-pol2qm74 1234 12 two two CD cord-015021-pol2qm74 1234 13 - - HYPH cord-015021-pol2qm74 1234 14 edged edge VBN cord-015021-pol2qm74 1234 15 sword sword NN cord-015021-pol2qm74 1234 16 in in IN cord-015021-pol2qm74 1234 17 a a DT cord-015021-pol2qm74 1234 18 clinical clinical JJ cord-015021-pol2qm74 1234 19 setting setting NN cord-015021-pol2qm74 1234 20 . . . cord-015021-pol2qm74 1235 1 Our -PRON- PRP$ cord-015021-pol2qm74 1235 2 knowledge knowledge NN cord-015021-pol2qm74 1235 3 of of IN cord-015021-pol2qm74 1235 4 the the DT cord-015021-pol2qm74 1235 5 role role NN cord-015021-pol2qm74 1235 6 of of IN cord-015021-pol2qm74 1235 7 adhesion adhesion NN cord-015021-pol2qm74 1235 8 molecules molecule NNS cord-015021-pol2qm74 1235 9 in in IN cord-015021-pol2qm74 1235 10 the the DT cord-015021-pol2qm74 1235 11 intlammatory intlammatory JJ cord-015021-pol2qm74 1235 12 response response NN cord-015021-pol2qm74 1235 13 has have VBZ cord-015021-pol2qm74 1235 14 increased increase VBN cord-015021-pol2qm74 1235 15 rapidly rapidly RB cord-015021-pol2qm74 1235 16 due due IN cord-015021-pol2qm74 1235 17 to to IN cord-015021-pol2qm74 1235 18 the the DT cord-015021-pol2qm74 1235 19 availability availability NN cord-015021-pol2qm74 1235 20 of of IN cord-015021-pol2qm74 1235 21 new new JJ cord-015021-pol2qm74 1235 22 reagents reagent NNS cord-015021-pol2qm74 1235 23 and and CC cord-015021-pol2qm74 1235 24 mice mouse NNS cord-015021-pol2qm74 1235 25 geneticly geneticly VBN cord-015021-pol2qm74 1235 26 deficient deficient JJ cord-015021-pol2qm74 1235 27 in in IN cord-015021-pol2qm74 1235 28 adhesion adhesion NN cord-015021-pol2qm74 1235 29 molecules molecule NNS cord-015021-pol2qm74 1235 30 . . . cord-015021-pol2qm74 1236 1 These these DT cord-015021-pol2qm74 1236 2 molecules molecule NNS cord-015021-pol2qm74 1236 3 are be VBP cord-015021-pol2qm74 1236 4 important important JJ cord-015021-pol2qm74 1236 5 in in IN cord-015021-pol2qm74 1236 6 interactions interaction NNS cord-015021-pol2qm74 1236 7 of of IN cord-015021-pol2qm74 1236 8 leukocytes leukocyte NNS cord-015021-pol2qm74 1236 9 with with IN cord-015021-pol2qm74 1236 10 endothelial endothelial JJ cord-015021-pol2qm74 1236 11 cells cell NNS cord-015021-pol2qm74 1236 12 , , , cord-015021-pol2qm74 1236 13 other other JJ cord-015021-pol2qm74 1236 14 leukocytes leukocyte NNS cord-015021-pol2qm74 1236 15 , , , cord-015021-pol2qm74 1236 16 platelets platelet NNS cord-015021-pol2qm74 1236 17 , , , cord-015021-pol2qm74 1236 18 and and CC cord-015021-pol2qm74 1236 19 epithelial epithelial JJ cord-015021-pol2qm74 1236 20 cells cell NNS cord-015021-pol2qm74 1236 21 . . . cord-015021-pol2qm74 1237 1 When when WRB cord-015021-pol2qm74 1237 2 these these DT cord-015021-pol2qm74 1237 3 molecules molecule NNS cord-015021-pol2qm74 1237 4 are be VBP cord-015021-pol2qm74 1237 5 engaged engage VBN cord-015021-pol2qm74 1237 6 , , , cord-015021-pol2qm74 1237 7 they -PRON- PRP cord-015021-pol2qm74 1237 8 can can MD cord-015021-pol2qm74 1237 9 also also RB cord-015021-pol2qm74 1237 10 play play VB cord-015021-pol2qm74 1237 11 a a DT cord-015021-pol2qm74 1237 12 role role NN cord-015021-pol2qm74 1237 13 in in IN cord-015021-pol2qm74 1237 14 activating activate VBG cord-015021-pol2qm74 1237 15 leukocytes leukocyte NNS cord-015021-pol2qm74 1237 16 and and CC cord-015021-pol2qm74 1237 17 their -PRON- PRP$ cord-015021-pol2qm74 1237 18 effector effector NN cord-015021-pol2qm74 1237 19 functions function NNS cord-015021-pol2qm74 1237 20 . . . cord-015021-pol2qm74 1238 1 In in IN cord-015021-pol2qm74 1238 2 the the DT cord-015021-pol2qm74 1238 3 venules venule NNS cord-015021-pol2qm74 1238 4 of of IN cord-015021-pol2qm74 1238 5 the the DT cord-015021-pol2qm74 1238 6 systemic systemic JJ cord-015021-pol2qm74 1238 7 circulation circulation NN cord-015021-pol2qm74 1238 8 , , , cord-015021-pol2qm74 1238 9 adhesion adhesion NN cord-015021-pol2qm74 1238 10 often often RB cord-015021-pol2qm74 1238 11 occurs occur VBZ cord-015021-pol2qm74 1238 12 through through IN cord-015021-pol2qm74 1238 13 a a DT cord-015021-pol2qm74 1238 14 series series NN cord-015021-pol2qm74 1238 15 of of IN cord-015021-pol2qm74 1238 16 sequential sequential JJ cord-015021-pol2qm74 1238 17 interactions interaction NNS cord-015021-pol2qm74 1238 18 . . . cord-015021-pol2qm74 1239 1 Initial initial JJ cord-015021-pol2qm74 1239 2 interactions interaction NNS cord-015021-pol2qm74 1239 3 are be VBP cord-015021-pol2qm74 1239 4 mediated mediate VBN cord-015021-pol2qm74 1239 5 by by IN cord-015021-pol2qm74 1239 6 members member NNS cord-015021-pol2qm74 1239 7 of of IN cord-015021-pol2qm74 1239 8 the the DT cord-015021-pol2qm74 1239 9 selectin selectin NNP cord-015021-pol2qm74 1239 10 family family NN cord-015021-pol2qm74 1239 11 to to TO cord-015021-pol2qm74 1239 12 loosely loosely RB cord-015021-pol2qm74 1239 13 associate associate VB cord-015021-pol2qm74 1239 14 the the DT cord-015021-pol2qm74 1239 15 leukocytes leukocyte NNS cord-015021-pol2qm74 1239 16 with with IN cord-015021-pol2qm74 1239 17 the the DT cord-015021-pol2qm74 1239 18 endothelium endothelium NN cord-015021-pol2qm74 1239 19 and and CC cord-015021-pol2qm74 1239 20 are be VBP cord-015021-pol2qm74 1239 21 followed follow VBN cord-015021-pol2qm74 1239 22 by by IN cord-015021-pol2qm74 1239 23 firm firm JJ cord-015021-pol2qm74 1239 24 adhesion adhesion NN cord-015021-pol2qm74 1239 25 requiring require VBG cord-015021-pol2qm74 1239 26 members member NNS cord-015021-pol2qm74 1239 27 of of IN cord-015021-pol2qm74 1239 28 the the DT cord-015021-pol2qm74 1239 29 integrin integrin NN cord-015021-pol2qm74 1239 30 and and CC cord-015021-pol2qm74 1239 31 immunoglobulin immunoglobulin NN cord-015021-pol2qm74 1239 32 family family NN cord-015021-pol2qm74 1239 33 . . . cord-015021-pol2qm74 1240 1 Later later JJ cord-015021-pol2qm74 1240 2 interactions interaction NNS cord-015021-pol2qm74 1240 3 with with IN cord-015021-pol2qm74 1240 4 endothelium endothelium NN cord-015021-pol2qm74 1240 5 may may MD cord-015021-pol2qm74 1240 6 require require VB cord-015021-pol2qm74 1240 7 PECAM PECAM NNP cord-015021-pol2qm74 1240 8 . . . cord-015021-pol2qm74 1241 1 Adhesion adhesion NN cord-015021-pol2qm74 1241 2 molecules molecule NNS cord-015021-pol2qm74 1241 3 are be VBP cord-015021-pol2qm74 1241 4 usually usually RB cord-015021-pol2qm74 1241 5 required require VBN cord-015021-pol2qm74 1241 6 for for IN cord-015021-pol2qm74 1241 7 leukocyte leukocyte NN cord-015021-pol2qm74 1241 8 emigration emigration NN cord-015021-pol2qm74 1241 9 in in IN cord-015021-pol2qm74 1241 10 response response NN cord-015021-pol2qm74 1241 11 to to IN cord-015021-pol2qm74 1241 12 extravascular extravascular JJ cord-015021-pol2qm74 1241 13 stimuli stimulus NNS cord-015021-pol2qm74 1241 14 and and CC cord-015021-pol2qm74 1241 15 for for IN cord-015021-pol2qm74 1241 16 neutrophil neutrophil NN cord-015021-pol2qm74 1241 17 - - HYPH cord-015021-pol2qm74 1241 18 mediated mediate VBN cord-015021-pol2qm74 1241 19 endothelial endothelial JJ cord-015021-pol2qm74 1241 20 cell cell NN cord-015021-pol2qm74 1241 21 injury injury NN cord-015021-pol2qm74 1241 22 . . . cord-015021-pol2qm74 1242 1 They -PRON- PRP cord-015021-pol2qm74 1242 2 are be VBP cord-015021-pol2qm74 1242 3 critical critical JJ cord-015021-pol2qm74 1242 4 for for IN cord-015021-pol2qm74 1242 5 host host NN cord-015021-pol2qm74 1242 6 response response NN cord-015021-pol2qm74 1242 7 in in IN cord-015021-pol2qm74 1242 8 many many JJ cord-015021-pol2qm74 1242 9 diseases disease NNS cord-015021-pol2qm74 1242 10 including include VBG cord-015021-pol2qm74 1242 11 infections infection NNS cord-015021-pol2qm74 1242 12 . . . cord-015021-pol2qm74 1243 1 However however RB cord-015021-pol2qm74 1243 2 , , , cord-015021-pol2qm74 1243 3 when when WRB cord-015021-pol2qm74 1243 4 the the DT cord-015021-pol2qm74 1243 5 inflammatory inflammatory JJ cord-015021-pol2qm74 1243 6 response response NN cord-015021-pol2qm74 1243 7 results result NNS cord-015021-pol2qm74 1243 8 in in IN cord-015021-pol2qm74 1243 9 damage damage NN cord-015021-pol2qm74 1243 10 to to IN cord-015021-pol2qm74 1243 11 host host NN cord-015021-pol2qm74 1243 12 tissues tissue NNS cord-015021-pol2qm74 1243 13 , , , cord-015021-pol2qm74 1243 14 patients patient NNS cord-015021-pol2qm74 1243 15 may may MD cord-015021-pol2qm74 1243 16 benefit benefit VB cord-015021-pol2qm74 1243 17 from from IN cord-015021-pol2qm74 1243 18 blocking block VBG cord-015021-pol2qm74 1243 19 the the DT cord-015021-pol2qm74 1243 20 leukocyte leukocyte NN cord-015021-pol2qm74 1243 21 response response NN cord-015021-pol2qm74 1243 22 . . . cord-015021-pol2qm74 1244 1 Anti anti JJ cord-015021-pol2qm74 1244 2 - - JJ cord-015021-pol2qm74 1244 3 adhesion adhesion NN cord-015021-pol2qm74 1244 4 molecule molecule NN cord-015021-pol2qm74 1244 5 agents agent NNS cord-015021-pol2qm74 1244 6 are be VBP cord-015021-pol2qm74 1244 7 an an DT cord-015021-pol2qm74 1244 8 important important JJ cord-015021-pol2qm74 1244 9 potential potential JJ cord-015021-pol2qm74 1244 10 antiinflammatory antiinflammatory JJ cord-015021-pol2qm74 1244 11 therapy therapy NN cord-015021-pol2qm74 1244 12 . . . cord-015021-pol2qm74 1245 1 The the DT cord-015021-pol2qm74 1245 2 focus focus NN cord-015021-pol2qm74 1245 3 of of IN cord-015021-pol2qm74 1245 4 anti anti JJ cord-015021-pol2qm74 1245 5 - - JJ cord-015021-pol2qm74 1245 6 adhesion adhesion JJ cord-015021-pol2qm74 1245 7 therapy therapy NN cord-015021-pol2qm74 1245 8 may may MD cord-015021-pol2qm74 1245 9 be be VB cord-015021-pol2qm74 1245 10 at at IN cord-015021-pol2qm74 1245 11 any any DT cord-015021-pol2qm74 1245 12 step step NN cord-015021-pol2qm74 1245 13 of of IN cord-015021-pol2qm74 1245 14 the the DT cord-015021-pol2qm74 1245 15 sequence sequence NN cord-015021-pol2qm74 1245 16 . . . cord-015021-pol2qm74 1246 1 Diseases disease NNS cord-015021-pol2qm74 1246 2 where where WRB cord-015021-pol2qm74 1246 3 anti anti JJ cord-015021-pol2qm74 1246 4 - - JJ cord-015021-pol2qm74 1246 5 adhesion adhesion JJ cord-015021-pol2qm74 1246 6 molecule molecule NN cord-015021-pol2qm74 1246 7 therapy therapy NN cord-015021-pol2qm74 1246 8 may may MD cord-015021-pol2qm74 1246 9 benefit benefit VB cord-015021-pol2qm74 1246 10 patients patient NNS cord-015021-pol2qm74 1246 11 include include VBP cord-015021-pol2qm74 1246 12 ischemia ischemia NN cord-015021-pol2qm74 1246 13 / / SYM cord-015021-pol2qm74 1246 14 reperfusion reperfusion NN cord-015021-pol2qm74 1246 15 injury injury NN cord-015021-pol2qm74 1246 16 in in IN cord-015021-pol2qm74 1246 17 many many JJ cord-015021-pol2qm74 1246 18 organs organ NNS cord-015021-pol2qm74 1246 19 , , , cord-015021-pol2qm74 1246 20 ARDS ARDS NNP cord-015021-pol2qm74 1246 21 and and CC cord-015021-pol2qm74 1246 22 MOF MOF NNP cord-015021-pol2qm74 1246 23 , , , cord-015021-pol2qm74 1246 24 and and CC cord-015021-pol2qm74 1246 25 transplantation transplantation NN cord-015021-pol2qm74 1246 26 , , , cord-015021-pol2qm74 1246 27 both both DT cord-015021-pol2qm74 1246 28 to to TO cord-015021-pol2qm74 1246 29 protect protect VB cord-015021-pol2qm74 1246 30 the the DT cord-015021-pol2qm74 1246 31 donor donor NN cord-015021-pol2qm74 1246 32 organ organ NN cord-015021-pol2qm74 1246 33 from from IN cord-015021-pol2qm74 1246 34 ischemia ischemia NN cord-015021-pol2qm74 1246 35 / / SYM cord-015021-pol2qm74 1246 36 reperfusion reperfusion NN cord-015021-pol2qm74 1246 37 injury injury NN cord-015021-pol2qm74 1246 38 and and CC cord-015021-pol2qm74 1246 39 to to TO cord-015021-pol2qm74 1246 40 inhibit inhibit VB cord-015021-pol2qm74 1246 41 graft graft NN cord-015021-pol2qm74 1246 42 vs vs IN cord-015021-pol2qm74 1246 43 host host NN cord-015021-pol2qm74 1246 44 disease disease NN cord-015021-pol2qm74 1246 45 . . . cord-015021-pol2qm74 1247 1 Many many JJ cord-015021-pol2qm74 1247 2 strategies strategy NNS cord-015021-pol2qm74 1247 3 have have VBP cord-015021-pol2qm74 1247 4 been be VBN cord-015021-pol2qm74 1247 5 considered consider VBN cord-015021-pol2qm74 1247 6 and and CC cord-015021-pol2qm74 1247 7 include include VBP cord-015021-pol2qm74 1247 8 : : : cord-015021-pol2qm74 1247 9 1 1 LS cord-015021-pol2qm74 1247 10 ) ) -RRB- cord-015021-pol2qm74 1247 11 blocking block VBG cord-015021-pol2qm74 1247 12 the the DT cord-015021-pol2qm74 1247 13 ability ability NN cord-015021-pol2qm74 1247 14 of of IN cord-015021-pol2qm74 1247 15 adhesion adhesion NN cord-015021-pol2qm74 1247 16 molecules molecule NNS cord-015021-pol2qm74 1247 17 to to TO cord-015021-pol2qm74 1247 18 recognize recognize VB cord-015021-pol2qm74 1247 19 their -PRON- PRP$ cord-015021-pol2qm74 1247 20 ligand ligand NN cord-015021-pol2qm74 1247 21 using use VBG cord-015021-pol2qm74 1247 22 antibodies antibody NNS cord-015021-pol2qm74 1247 23 that that WDT cord-015021-pol2qm74 1247 24 have have VBP cord-015021-pol2qm74 1247 25 been be VBN cord-015021-pol2qm74 1247 26 humanized humanize VBN cord-015021-pol2qm74 1247 27 or or CC cord-015021-pol2qm74 1247 28 soluble soluble JJ cord-015021-pol2qm74 1247 29 receptors receptor NNS cord-015021-pol2qm74 1247 30 linked link VBN cord-015021-pol2qm74 1247 31 to to IN cord-015021-pol2qm74 1247 32 IgG IgG NNP cord-015021-pol2qm74 1247 33 to to TO cord-015021-pol2qm74 1247 34 prolong prolong VB cord-015021-pol2qm74 1247 35 their -PRON- PRP$ cord-015021-pol2qm74 1247 36 circulating circulate VBG cord-015021-pol2qm74 1247 37 halflife halflife NN cord-015021-pol2qm74 1247 38 , , , cord-015021-pol2qm74 1247 39 2 2 LS cord-015021-pol2qm74 1247 40 ) ) -RRB- cord-015021-pol2qm74 1247 41 blocking block VBG cord-015021-pol2qm74 1247 42 the the DT cord-015021-pol2qm74 1247 43 ligands ligand NNS cord-015021-pol2qm74 1247 44 for for IN cord-015021-pol2qm74 1247 45 adhesion adhesion NN cord-015021-pol2qm74 1247 46 molecules molecule NNS cord-015021-pol2qm74 1247 47 using use VBG cord-015021-pol2qm74 1247 48 soluble soluble JJ cord-015021-pol2qm74 1247 49 adhesion adhesion NN cord-015021-pol2qm74 1247 50 molecules molecule NNS cord-015021-pol2qm74 1247 51 , , , cord-015021-pol2qm74 1247 52 peptide peptide JJ cord-015021-pol2qm74 1247 53 analogues analogue NNS cord-015021-pol2qm74 1247 54 , , , cord-015021-pol2qm74 1247 55 or or CC cord-015021-pol2qm74 1247 56 oligosaccharides oligosaccharide NNS cord-015021-pol2qm74 1247 57 , , , cord-015021-pol2qm74 1247 58 and and CC cord-015021-pol2qm74 1247 59 3 3 LS cord-015021-pol2qm74 1247 60 ) ) -RRB- cord-015021-pol2qm74 1247 61 blocking block VBG cord-015021-pol2qm74 1247 62 the the DT cord-015021-pol2qm74 1247 63 production production NN cord-015021-pol2qm74 1247 64 of of IN cord-015021-pol2qm74 1247 65 the the DT cord-015021-pol2qm74 1247 66 adhesion adhesion NN cord-015021-pol2qm74 1247 67 molecule molecule NN cord-015021-pol2qm74 1247 68 using use VBG cord-015021-pol2qm74 1247 69 anti anti JJ cord-015021-pol2qm74 1247 70 - - JJ cord-015021-pol2qm74 1247 71 sense sense JJ cord-015021-pol2qm74 1247 72 oligonucleotides oligonucleotide NNS cord-015021-pol2qm74 1247 73 . . . cord-015021-pol2qm74 1248 1 Because because IN cord-015021-pol2qm74 1248 2 the the DT cord-015021-pol2qm74 1248 3 synthesis synthesis NN cord-015021-pol2qm74 1248 4 of of IN cord-015021-pol2qm74 1248 5 adhesion adhesion NN cord-015021-pol2qm74 1248 6 molecules molecule NNS cord-015021-pol2qm74 1248 7 is be VBZ cord-015021-pol2qm74 1248 8 usually usually RB cord-015021-pol2qm74 1248 9 regulated regulate VBN cord-015021-pol2qm74 1248 10 by by IN cord-015021-pol2qm74 1248 11 cytokines cytokine NNS cord-015021-pol2qm74 1248 12 , , , cord-015021-pol2qm74 1248 13 inhibiting inhibit VBG cord-015021-pol2qm74 1248 14 the the DT cord-015021-pol2qm74 1248 15 action action NN cord-015021-pol2qm74 1248 16 of of IN cord-015021-pol2qm74 1248 17 cytokines cytokine NNS cord-015021-pol2qm74 1248 18 is be VBZ cord-015021-pol2qm74 1248 19 another another DT cord-015021-pol2qm74 1248 20 potential potential JJ cord-015021-pol2qm74 1248 21 site site NN cord-015021-pol2qm74 1248 22 for for IN cord-015021-pol2qm74 1248 23 interrupting interrupt VBG cord-015021-pol2qm74 1248 24 the the DT cord-015021-pol2qm74 1248 25 adhesion adhesion NN cord-015021-pol2qm74 1248 26 process process NN cord-015021-pol2qm74 1248 27 . . . cord-015021-pol2qm74 1249 1 Although although IN cord-015021-pol2qm74 1249 2 important important JJ cord-015021-pol2qm74 1249 3 issues issue NNS cord-015021-pol2qm74 1249 4 of of IN cord-015021-pol2qm74 1249 5 safety safety NN cord-015021-pol2qm74 1249 6 must must MD cord-015021-pol2qm74 1249 7 be be VB cord-015021-pol2qm74 1249 8 evaluated evaluate VBN cord-015021-pol2qm74 1249 9 , , , cord-015021-pol2qm74 1249 10 the the DT cord-015021-pol2qm74 1249 11 potential potential NN cord-015021-pol2qm74 1249 12 for for IN cord-015021-pol2qm74 1249 13 modulating modulate VBG cord-015021-pol2qm74 1249 14 the the DT cord-015021-pol2qm74 1249 15 inflammatory inflammatory JJ cord-015021-pol2qm74 1249 16 response response NN cord-015021-pol2qm74 1249 17 make make VBP cord-015021-pol2qm74 1249 18 this this DT cord-015021-pol2qm74 1249 19 an an DT cord-015021-pol2qm74 1249 20 exciting exciting JJ cord-015021-pol2qm74 1249 21 area area NN cord-015021-pol2qm74 1249 22 of of IN cord-015021-pol2qm74 1249 23 improvement improvement NN cord-015021-pol2qm74 1249 24 in in IN cord-015021-pol2qm74 1249 25 health health NN cord-015021-pol2qm74 1249 26 care care NN cord-015021-pol2qm74 1249 27 delivery delivery NN cord-015021-pol2qm74 1249 28 . . . cord-015021-pol2qm74 1250 1 Claire Claire NNP cord-015021-pol2qm74 1250 2 M. M. NNP cord-015021-pol2qm74 1250 3 Doerschuk Doerschuk NNP cord-015021-pol2qm74 1250 4 , , , cord-015021-pol2qm74 1250 5 M.D. M.D. NNP cord-015021-pol2qm74 1250 6 ; ; : cord-015021-pol2qm74 1250 7 Riley Riley NNP cord-015021-pol2qm74 1250 8 Hospital Hospital NNP cord-015021-pol2qm74 1250 9 for for IN cord-015021-pol2qm74 1250 10 Children Children NNP cord-015021-pol2qm74 1250 11 , , , cord-015021-pol2qm74 1250 12 Room room NN cord-015021-pol2qm74 1250 13 2600 2600 CD cord-015021-pol2qm74 1250 14 ; ; : cord-015021-pol2qm74 1250 15 702 702 CD cord-015021-pol2qm74 1250 16 Barnhill Barnhill NNP cord-015021-pol2qm74 1250 17 Drive Drive NNP cord-015021-pol2qm74 1250 18 ; ; : cord-015021-pol2qm74 1250 19 Indianapolis Indianapolis NNP cord-015021-pol2qm74 1250 20 , , , cord-015021-pol2qm74 1250 21 IN in IN cord-015021-pol2qm74 1250 22 46202 46202 CD cord-015021-pol2qm74 1250 23 USA USA NNP cord-015021-pol2qm74 1250 24 . . . cord-015021-pol2qm74 1251 1 Modulation modulation NN cord-015021-pol2qm74 1251 2 of of IN cord-015021-pol2qm74 1251 3 neutrophil neutrophil NN cord-015021-pol2qm74 1251 4 - - HYPH cord-015021-pol2qm74 1251 5 endothelial endothelial JJ cord-015021-pol2qm74 1251 6 cell cell NN cord-015021-pol2qm74 1251 7 adhesion adhesion NN cord-015021-pol2qm74 1251 8 with with IN cord-015021-pol2qm74 1251 9 anti anti JJ cord-015021-pol2qm74 1251 10 - - NNS cord-015021-pol2qm74 1251 11 CDl CDl NNS cord-015021-pol2qm74 1251 12 I I NNP cord-015021-pol2qm74 1251 13 / / SYM cord-015021-pol2qm74 1251 14 CD18 CD18 NNP cord-015021-pol2qm74 1251 15 monoclonal monoclonal JJ cord-015021-pol2qm74 1251 16 antibodies antibody NNS cord-015021-pol2qm74 1251 17 as as IN cord-015021-pol2qm74 1251 18 a a DT cord-015021-pol2qm74 1251 19 therapeutic therapeutic JJ cord-015021-pol2qm74 1251 20 modality modality NN cord-015021-pol2qm74 1251 21 . . . cord-015021-pol2qm74 1252 1 CH CH NNP cord-015021-pol2qm74 1252 2 Wortel Wortel NNP cord-015021-pol2qm74 1252 3 , , , cord-015021-pol2qm74 1252 4 Repligen Repligen NNP cord-015021-pol2qm74 1252 5 Corporation Corporation NNP cord-015021-pol2qm74 1252 6 , , , cord-015021-pol2qm74 1252 7 One one CD cord-015021-pol2qm74 1252 8 Kendall Kendall NNP cord-015021-pol2qm74 1252 9 Square Square NNP cord-015021-pol2qm74 1252 10 , , , cord-015021-pol2qm74 1252 11 Building Building NNP cord-015021-pol2qm74 1252 12 700 700 CD cord-015021-pol2qm74 1252 13 , , , cord-015021-pol2qm74 1252 14 Cambridge Cambridge NNP cord-015021-pol2qm74 1252 15 , , , cord-015021-pol2qm74 1252 16 MA MA NNP cord-015021-pol2qm74 1252 17 02139 02139 CD cord-015021-pol2qm74 1252 18 , , , cord-015021-pol2qm74 1252 19 USA USA NNP cord-015021-pol2qm74 1252 20 . . . cord-015021-pol2qm74 1253 1 The the DT cord-015021-pol2qm74 1253 2 central central JJ cord-015021-pol2qm74 1253 3 role role NN cord-015021-pol2qm74 1253 4 of of IN cord-015021-pol2qm74 1253 5 inflammatory inflammatory JJ cord-015021-pol2qm74 1253 6 cells cell NNS cord-015021-pol2qm74 1253 7 in in IN cord-015021-pol2qm74 1253 8 the the DT cord-015021-pol2qm74 1253 9 pathogenesis pathogenesis NN cord-015021-pol2qm74 1253 10 of of IN cord-015021-pol2qm74 1253 11 lung lung NN cord-015021-pol2qm74 1253 12 and and CC cord-015021-pol2qm74 1253 13 systemic systemic JJ cord-015021-pol2qm74 1253 14 organ organ NN cord-015021-pol2qm74 1253 15 injury injury NN cord-015021-pol2qm74 1253 16 is be VBZ cord-015021-pol2qm74 1253 17 well well RB cord-015021-pol2qm74 1253 18 recognized recognize VBN cord-015021-pol2qm74 1253 19 . . . cord-015021-pol2qm74 1254 1 Binding bind VBG cord-015021-pol2qm74 1254 2 of of IN cord-015021-pol2qm74 1254 3 neutrophils neutrophil NNS cord-015021-pol2qm74 1254 4 to to IN cord-015021-pol2qm74 1254 5 endothelial endothelial JJ cord-015021-pol2qm74 1254 6 cells cell NNS cord-015021-pol2qm74 1254 7 and and CC cord-015021-pol2qm74 1254 8 migration migration NN cord-015021-pol2qm74 1254 9 into into IN cord-015021-pol2qm74 1254 10 the the DT cord-015021-pol2qm74 1254 11 parenchyma parenchyma NN cord-015021-pol2qm74 1254 12 are be VBP cord-015021-pol2qm74 1254 13 largely largely RB cord-015021-pol2qm74 1254 14 regulated regulate VBN cord-015021-pol2qm74 1254 15 by by IN cord-015021-pol2qm74 1254 16 complementary complementary JJ cord-015021-pol2qm74 1254 17 adhesion adhesion NN cord-015021-pol2qm74 1254 18 molecules molecule NNS cord-015021-pol2qm74 1254 19 . . . cord-015021-pol2qm74 1255 1 The the DT cord-015021-pol2qm74 1255 2 leukocyte leukocyte NN cord-015021-pol2qm74 1255 3 integrins integrin NNS cord-015021-pol2qm74 1255 4 are be VBP cord-015021-pol2qm74 1255 5 glycoproteins glycoprotein NNS cord-015021-pol2qm74 1255 6 expressed express VBN cord-015021-pol2qm74 1255 7 on on IN cord-015021-pol2qm74 1255 8 the the DT cord-015021-pol2qm74 1255 9 neutrophil neutrophil NN cord-015021-pol2qm74 1255 10 surface surface NN cord-015021-pol2qm74 1255 11 and and CC cord-015021-pol2qm74 1255 12 in in IN cord-015021-pol2qm74 1255 13 the the DT cord-015021-pol2qm74 1255 14 cytoplasmic cytoplasmic JJ cord-015021-pol2qm74 1255 15 granules granule NNS cord-015021-pol2qm74 1255 16 . . . cord-015021-pol2qm74 1256 1 Integrins integrin NNS cord-015021-pol2qm74 1256 2 consist consist VBP cord-015021-pol2qm74 1256 3 of of IN cord-015021-pol2qm74 1256 4 a a DT cord-015021-pol2qm74 1256 5 common common JJ cord-015021-pol2qm74 1256 6 beta2 beta2 NN cord-015021-pol2qm74 1256 7 or or CC cord-015021-pol2qm74 1256 8 cluster cluster NN cord-015021-pol2qm74 1256 9 differentiation differentiation NN cord-015021-pol2qm74 1257 1 ( ( -LRB- cord-015021-pol2qm74 1257 2 CD)18 CD)18 NNP cord-015021-pol2qm74 1257 3 chain chain VBP cord-015021-pol2qm74 1257 4 covalently covalently RB cord-015021-pol2qm74 1257 5 linked link VBN cord-015021-pol2qm74 1257 6 to to IN cord-015021-pol2qm74 1257 7 one one CD cord-015021-pol2qm74 1257 8 of of IN cord-015021-pol2qm74 1257 9 three three CD cord-015021-pol2qm74 1257 10 different different JJ cord-015021-pol2qm74 1257 11 alpha alpha NN cord-015021-pol2qm74 1257 12 chains chain NNS cord-015021-pol2qm74 1257 13 ( ( -LRB- cord-015021-pol2qm74 1257 14 CDlla CDlla NNPS cord-015021-pol2qm74 1257 15 , , , cord-015021-pol2qm74 1257 16 CDllb CDllb NNP cord-015021-pol2qm74 1257 17 , , , cord-015021-pol2qm74 1257 18 CDIlc CDIlc NNP cord-015021-pol2qm74 1257 19 ) ) -RRB- cord-015021-pol2qm74 1257 20 and and CC cord-015021-pol2qm74 1257 21 exist exist VB cord-015021-pol2qm74 1257 22 on on IN cord-015021-pol2qm74 1257 23 the the DT cord-015021-pol2qm74 1257 24 cell cell NN cord-015021-pol2qm74 1257 25 surface surface NN cord-015021-pol2qm74 1257 26 as as IN cord-015021-pol2qm74 1257 27 three three CD cord-015021-pol2qm74 1257 28 distinct distinct JJ cord-015021-pol2qm74 1257 29 heterodimers heterodimer NNS cord-015021-pol2qm74 1257 30 . . . cord-015021-pol2qm74 1258 1 CDlla/ CDlla/ NNPS cord-015021-pol2qm74 1259 1 CD18 CD18 NNP cord-015021-pol2qm74 1259 2 is be VBZ cord-015021-pol2qm74 1259 3 expressed express VBN cord-015021-pol2qm74 1259 4 on on IN cord-015021-pol2qm74 1259 5 all all DT cord-015021-pol2qm74 1259 6 leukocytes leukocyte NNS cord-015021-pol2qm74 1259 7 , , , cord-015021-pol2qm74 1259 8 whereas whereas IN cord-015021-pol2qm74 1259 9 CD CD NNP cord-015021-pol2qm74 1259 10 11 11 CD cord-015021-pol2qm74 1259 11 b b NN cord-015021-pol2qm74 1259 12 / / SYM cord-015021-pol2qm74 1259 13 CD CD NNP cord-015021-pol2qm74 1259 14 18 18 CD cord-015021-pol2qm74 1259 15 and and CC cord-015021-pol2qm74 1259 16 CD CD NNP cord-015021-pol2qm74 1259 17 11 11 CD cord-015021-pol2qm74 1260 1 c c NNP cord-015021-pol2qm74 1260 2 / / SYM cord-015021-pol2qm74 1260 3 CD CD NNP cord-015021-pol2qm74 1260 4 1.8 1.8 CD cord-015021-pol2qm74 1260 5 are be VBP cord-015021-pol2qm74 1260 6 restricted restrict VBN cord-015021-pol2qm74 1260 7 to to IN cord-015021-pol2qm74 1260 8 cells cell NNS cord-015021-pol2qm74 1260 9 of of IN cord-015021-pol2qm74 1260 10 myeloid myeloid JJ cord-015021-pol2qm74 1260 11 origin origin NN cord-015021-pol2qm74 1260 12 . . . cord-015021-pol2qm74 1261 1 CD CD NNP cord-015021-pol2qm74 1262 1 i i PRP cord-015021-pol2qm74 1262 2 1/ 1/ CD cord-015021-pol2qm74 1262 3 CD CD NNP cord-015021-pol2qm74 1262 4 18 18 CD cord-015021-pol2qm74 1262 5 interacts interact VBZ cord-015021-pol2qm74 1262 6 with with IN cord-015021-pol2qm74 1262 7 intracellular intracellular JJ cord-015021-pol2qm74 1262 8 adhesion adhesion NN cord-015021-pol2qm74 1262 9 molecule-1 molecule-1 NN cord-015021-pol2qm74 1263 1 ( ( -LRB- cord-015021-pol2qm74 1263 2 ICAM ICAM NNP cord-015021-pol2qm74 1263 3 - - HYPH cord-015021-pol2qm74 1263 4 I I NNP cord-015021-pol2qm74 1263 5 ) ) -RRB- cord-015021-pol2qm74 1263 6 , , , cord-015021-pol2qm74 1263 7 its -PRON- PRP$ cord-015021-pol2qm74 1263 8 ligand ligand NN cord-015021-pol2qm74 1263 9 on on IN cord-015021-pol2qm74 1263 10 endothelial endothelial JJ cord-015021-pol2qm74 1263 11 cells cell NNS cord-015021-pol2qm74 1263 12 . . . cord-015021-pol2qm74 1264 1 The the DT cord-015021-pol2qm74 1264 2 potential potential NN cord-015021-pol2qm74 1264 3 for for IN cord-015021-pol2qm74 1264 4 monoclonal monoclonal JJ cord-015021-pol2qm74 1264 5 antibodies antibody NNS cord-015021-pol2qm74 1264 6 to to TO cord-015021-pol2qm74 1264 7 adhesion adhesion NN cord-015021-pol2qm74 1264 8 proteins protein NNS cord-015021-pol2qm74 1264 9 to to TO cord-015021-pol2qm74 1264 10 reduce reduce VB cord-015021-pol2qm74 1264 11 vascular vascular JJ cord-015021-pol2qm74 1264 12 and and CC cord-015021-pol2qm74 1264 13 tissue tissue NN cord-015021-pol2qm74 1264 14 damage damage NN cord-015021-pol2qm74 1264 15 has have VBZ cord-015021-pol2qm74 1264 16 been be VBN cord-015021-pol2qm74 1264 17 studied study VBN cord-015021-pol2qm74 1264 18 in in IN cord-015021-pol2qm74 1264 19 a a DT cord-015021-pol2qm74 1264 20 large large JJ cord-015021-pol2qm74 1264 21 number number NN cord-015021-pol2qm74 1264 22 of of IN cord-015021-pol2qm74 1264 23 experimental experimental JJ cord-015021-pol2qm74 1264 24 models model NNS cord-015021-pol2qm74 1264 25 . . . cord-015021-pol2qm74 1265 1 Protective protective JJ cord-015021-pol2qm74 1265 2 effects effect NNS cord-015021-pol2qm74 1265 3 with with IN cord-015021-pol2qm74 1265 4 anti anti JJ cord-015021-pol2qm74 1265 5 - - JJ cord-015021-pol2qm74 1265 6 CD18 cd18 JJ cord-015021-pol2qm74 1265 7 antibodies antibody NNS cord-015021-pol2qm74 1265 8 have have VBP cord-015021-pol2qm74 1265 9 been be VBN cord-015021-pol2qm74 1265 10 observed observe VBN cord-015021-pol2qm74 1265 11 in in IN cord-015021-pol2qm74 1265 12 a a DT cord-015021-pol2qm74 1265 13 wide wide JJ cord-015021-pol2qm74 1265 14 variety variety NN cord-015021-pol2qm74 1265 15 of of IN cord-015021-pol2qm74 1265 16 inflammatory inflammatory JJ cord-015021-pol2qm74 1265 17 , , , cord-015021-pol2qm74 1265 18 immune immune JJ cord-015021-pol2qm74 1265 19 , , , cord-015021-pol2qm74 1265 20 and and CC cord-015021-pol2qm74 1265 21 isehemia isehemia NN cord-015021-pol2qm74 1265 22 - - HYPH cord-015021-pol2qm74 1265 23 reperfusion reperfusion NN cord-015021-pol2qm74 1265 24 injuries injury NNS cord-015021-pol2qm74 1265 25 , , , cord-015021-pol2qm74 1265 26 such such JJ cord-015021-pol2qm74 1265 27 as as IN cord-015021-pol2qm74 1265 28 arthritis arthritis NN cord-015021-pol2qm74 1265 29 , , , cord-015021-pol2qm74 1265 30 burns burn NNS cord-015021-pol2qm74 1265 31 , , , cord-015021-pol2qm74 1265 32 endotoxic endotoxic JJ cord-015021-pol2qm74 1265 33 shock shock NN cord-015021-pol2qm74 1265 34 , , , cord-015021-pol2qm74 1265 35 bacterial bacterial JJ cord-015021-pol2qm74 1265 36 meningitis meningitis NN cord-015021-pol2qm74 1265 37 , , , cord-015021-pol2qm74 1265 38 autoimmune autoimmune JJ cord-015021-pol2qm74 1265 39 diabetes diabetes NN cord-015021-pol2qm74 1265 40 , , , cord-015021-pol2qm74 1265 41 nerve nerve NN cord-015021-pol2qm74 1265 42 degenemrion degenemrion NN cord-015021-pol2qm74 1265 43 , , , cord-015021-pol2qm74 1265 44 allograft allograft NN cord-015021-pol2qm74 1265 45 rejection rejection NN cord-015021-pol2qm74 1265 46 , , , cord-015021-pol2qm74 1265 47 allergic allergic JJ cord-015021-pol2qm74 1265 48 asthma asthma NN cord-015021-pol2qm74 1265 49 , , , cord-015021-pol2qm74 1265 50 acute acute JJ cord-015021-pol2qm74 1265 51 lung lung NN cord-015021-pol2qm74 1265 52 inflammation inflammation NN cord-015021-pol2qm74 1265 53 , , , cord-015021-pol2qm74 1265 54 skin skin NN cord-015021-pol2qm74 1265 55 lesions lesion NNS cord-015021-pol2qm74 1265 56 , , , cord-015021-pol2qm74 1265 57 and and CC cord-015021-pol2qm74 1265 58 ischemia ischemia NN cord-015021-pol2qm74 1265 59 - - HYPH cord-015021-pol2qm74 1265 60 reperfusion reperfusion NN cord-015021-pol2qm74 1265 61 models model NNS cord-015021-pol2qm74 1265 62 of of IN cord-015021-pol2qm74 1265 63 the the DT cord-015021-pol2qm74 1265 64 intestine intestine NN cord-015021-pol2qm74 1265 65 , , , cord-015021-pol2qm74 1265 66 myocardium myocardium NN cord-015021-pol2qm74 1265 67 , , , cord-015021-pol2qm74 1265 68 lung lung NN cord-015021-pol2qm74 1265 69 , , , cord-015021-pol2qm74 1265 70 skeletal skeletal JJ cord-015021-pol2qm74 1265 71 muscle muscle NN cord-015021-pol2qm74 1265 72 , , , cord-015021-pol2qm74 1265 73 and and CC cord-015021-pol2qm74 1265 74 central central JJ cord-015021-pol2qm74 1265 75 nervous nervous JJ cord-015021-pol2qm74 1265 76 system system NN cord-015021-pol2qm74 1265 77 . . . cord-015021-pol2qm74 1266 1 Protective protective JJ cord-015021-pol2qm74 1266 2 effects effect NNS cord-015021-pol2qm74 1266 3 have have VBP cord-015021-pol2qm74 1266 4 also also RB cord-015021-pol2qm74 1266 5 been be VBN cord-015021-pol2qm74 1266 6 observed observe VBN cord-015021-pol2qm74 1266 7 in in IN cord-015021-pol2qm74 1266 8 animals animal NNS cord-015021-pol2qm74 1266 9 resuscitated resuscitate VBD cord-015021-pol2qm74 1266 10 following follow VBG cord-015021-pol2qm74 1266 11 hemorrhagic hemorrhagic JJ cord-015021-pol2qm74 1266 12 shock shock NN cord-015021-pol2qm74 1266 13 . . . cord-015021-pol2qm74 1267 1 Blockage blockage NN cord-015021-pol2qm74 1267 2 of of IN cord-015021-pol2qm74 1267 3 CD18 CD18 NNP cord-015021-pol2qm74 1267 4 , , , cord-015021-pol2qm74 1267 5 however however RB cord-015021-pol2qm74 1267 6 , , , cord-015021-pol2qm74 1267 7 would would MD cord-015021-pol2qm74 1267 8 affect affect VB cord-015021-pol2qm74 1267 9 all all DT cord-015021-pol2qm74 1267 10 leukocytes leukocyte NNS cord-015021-pol2qm74 1267 11 , , , cord-015021-pol2qm74 1267 12 as as IN cord-015021-pol2qm74 1267 13 would would MD cord-015021-pol2qm74 1267 14 antibodies antibody NNS cord-015021-pol2qm74 1267 15 to to IN cord-015021-pol2qm74 1267 16 CDlla CDlla NNP cord-015021-pol2qm74 1267 17 / / SYM cord-015021-pol2qm74 1267 18 CDI8 CDI8 NNP cord-015021-pol2qm74 1267 19 . . . cord-015021-pol2qm74 1268 1 Targeting Targeting NNP cord-015021-pol2qm74 1268 2 CDllb CDllb NNP cord-015021-pol2qm74 1268 3 / / SYM cord-015021-pol2qm74 1268 4 CD18 CD18 NNP cord-015021-pol2qm74 1268 5 would would MD cord-015021-pol2qm74 1268 6 affect affect VB cord-015021-pol2qm74 1268 7 cells cell NNS cord-015021-pol2qm74 1268 8 of of IN cord-015021-pol2qm74 1268 9 the the DT cord-015021-pol2qm74 1268 10 myeloid myeloid JJ cord-015021-pol2qm74 1268 11 lineage lineage NN cord-015021-pol2qm74 1268 12 only only RB cord-015021-pol2qm74 1268 13 , , , cord-015021-pol2qm74 1268 14 which which WDT cord-015021-pol2qm74 1268 15 could could MD cord-015021-pol2qm74 1268 16 prove prove VB cord-015021-pol2qm74 1268 17 to to TO cord-015021-pol2qm74 1268 18 be be VB cord-015021-pol2qm74 1268 19 beneficial beneficial JJ cord-015021-pol2qm74 1268 20 . . . cord-015021-pol2qm74 1269 1 CD11b/ CD11b/ NNS cord-015021-pol2qm74 1270 1 CD18 CD18 NNP cord-015021-pol2qm74 1270 2 is be VBZ cord-015021-pol2qm74 1270 3 not not RB cord-015021-pol2qm74 1270 4 only only RB cord-015021-pol2qm74 1270 5 involved involve VBN cord-015021-pol2qm74 1270 6 in in IN cord-015021-pol2qm74 1270 7 transendothelial transendothelial JJ cord-015021-pol2qm74 1270 8 migration migration NN cord-015021-pol2qm74 1270 9 , , , cord-015021-pol2qm74 1270 10 but but CC cord-015021-pol2qm74 1270 11 is be VBZ cord-015021-pol2qm74 1270 12 also also RB cord-015021-pol2qm74 1270 13 implicated implicate VBN cord-015021-pol2qm74 1270 14 in in IN cord-015021-pol2qm74 1270 15 adherencedependent adherencedependent NN cord-015021-pol2qm74 1270 16 formation formation NN cord-015021-pol2qm74 1270 17 of of IN cord-015021-pol2qm74 1270 18 reactive reactive JJ cord-015021-pol2qm74 1270 19 oxygen oxygen NN cord-015021-pol2qm74 1270 20 species specie NNS cord-015021-pol2qm74 1270 21 . . . cord-015021-pol2qm74 1271 1 Blocking block VBG cord-015021-pol2qm74 1271 2 CD1 CD1 NNP cord-015021-pol2qm74 1272 1 lb lb CD cord-015021-pol2qm74 1272 2 / / SYM cord-015021-pol2qm74 1272 3 CD18 CD18 NNP cord-015021-pol2qm74 1272 4 may may MD cord-015021-pol2qm74 1272 5 therefore therefore RB cord-015021-pol2qm74 1272 6 not not RB cord-015021-pol2qm74 1272 7 only only RB cord-015021-pol2qm74 1272 8 reduce reduce VB cord-015021-pol2qm74 1272 9 the the DT cord-015021-pol2qm74 1272 10 numbe numbe NN cord-015021-pol2qm74 1272 11 r r NN cord-015021-pol2qm74 1272 12 of of IN cord-015021-pol2qm74 1272 13 leukocytes leukocyte NNS cord-015021-pol2qm74 1272 14 accumulating accumulate VBG cord-015021-pol2qm74 1272 15 in in IN cord-015021-pol2qm74 1272 16 the the DT cord-015021-pol2qm74 1272 17 tissue tissue NN cord-015021-pol2qm74 1272 18 , , , cord-015021-pol2qm74 1272 19 but but CC cord-015021-pol2qm74 1272 20 also also RB cord-015021-pol2qm74 1272 21 attenuate attenuate VB cord-015021-pol2qm74 1272 22 the the DT cord-015021-pol2qm74 1272 23 oxidant oxidant JJ cord-015021-pol2qm74 1272 24 stress stress NN cord-015021-pol2qm74 1272 25 of of IN cord-015021-pol2qm74 1272 26 infiltrated infiltrate VBN cord-015021-pol2qm74 1272 27 neutrophils neutrophil NNS cord-015021-pol2qm74 1272 28 . . . cord-015021-pol2qm74 1273 1 Anti anti JJ cord-015021-pol2qm74 1273 2 - - JJ cord-015021-pol2qm74 1273 3 CD CD NNP cord-015021-pol2qm74 1273 4 11 11 CD cord-015021-pol2qm74 1273 5 b b NN cord-015021-pol2qm74 1273 6 treatment treatment NN cord-015021-pol2qm74 1273 7 has have VBZ cord-015021-pol2qm74 1273 8 been be VBN cord-015021-pol2qm74 1273 9 used use VBN cord-015021-pol2qm74 1273 10 effectively effectively RB cord-015021-pol2qm74 1273 11 to to TO cord-015021-pol2qm74 1273 12 reduce reduce VB cord-015021-pol2qm74 1273 13 tissue tissue NN cord-015021-pol2qm74 1273 14 injury injury NN cord-015021-pol2qm74 1273 15 initiated initiate VBN cord-015021-pol2qm74 1273 16 by by IN cord-015021-pol2qm74 1273 17 ischemia ischemia NN cord-015021-pol2qm74 1273 18 - - HYPH cord-015021-pol2qm74 1273 19 reperfusion reperfusion NN cord-015021-pol2qm74 1273 20 , , , cord-015021-pol2qm74 1273 21 complement complement NN cord-015021-pol2qm74 1273 22 activation activation NN cord-015021-pol2qm74 1273 23 and and CC cord-015021-pol2qm74 1273 24 endotoxemia endotoxemia NN cord-015021-pol2qm74 1273 25 . . . cord-015021-pol2qm74 1274 1 Altering alter VBG cord-015021-pol2qm74 1274 2 the the DT cord-015021-pol2qm74 1274 3 host host NN cord-015021-pol2qm74 1274 4 response response NN cord-015021-pol2qm74 1274 5 by by IN cord-015021-pol2qm74 1274 6 modulating modulate VBG cord-015021-pol2qm74 1274 7 the the DT cord-015021-pol2qm74 1274 8 function function NN cord-015021-pol2qm74 1274 9 of of IN cord-015021-pol2qm74 1274 10 adhesion adhesion NN cord-015021-pol2qm74 1274 11 molecules molecule NNS cord-015021-pol2qm74 1274 12 may may MD cord-015021-pol2qm74 1274 13 attenuate attenuate VB cord-015021-pol2qm74 1274 14 the the DT cord-015021-pol2qm74 1274 15 inadvertent inadvertent JJ cord-015021-pol2qm74 1274 16 injury injury NN cord-015021-pol2qm74 1274 17 caused cause VBN cord-015021-pol2qm74 1274 18 by by IN cord-015021-pol2qm74 1274 19 leukocytes leukocyte NNS cord-015021-pol2qm74 1274 20 , , , cord-015021-pol2qm74 1274 21 but but CC cord-015021-pol2qm74 1274 22 may may MD cord-015021-pol2qm74 1274 23 also also RB cord-015021-pol2qm74 1274 24 temporarily temporarily RB cord-015021-pol2qm74 1274 25 leave leave VB cord-015021-pol2qm74 1274 26 the the DT cord-015021-pol2qm74 1274 27 host host NN cord-015021-pol2qm74 1274 28 without without IN cord-015021-pol2qm74 1274 29 effective effective JJ cord-015021-pol2qm74 1274 30 defense defense NN cord-015021-pol2qm74 1274 31 machinery machinery NN cord-015021-pol2qm74 1274 32 . . . cord-015021-pol2qm74 1275 1 Overall overall RB cord-015021-pol2qm74 1275 2 , , , cord-015021-pol2qm74 1275 3 animal animal NN cord-015021-pol2qm74 1275 4 studies study NNS cord-015021-pol2qm74 1275 5 suggest suggest VBP cord-015021-pol2qm74 1275 6 that that IN cord-015021-pol2qm74 1275 7 it -PRON- PRP cord-015021-pol2qm74 1275 8 may may MD cord-015021-pol2qm74 1275 9 be be VB cord-015021-pol2qm74 1275 10 safe safe JJ cord-015021-pol2qm74 1275 11 to to TO cord-015021-pol2qm74 1275 12 inhibit inhibit VB cord-015021-pol2qm74 1275 13 neutrophil neutrophil NN cord-015021-pol2qm74 1275 14 adhesion adhesion NN cord-015021-pol2qm74 1275 15 for for IN cord-015021-pol2qm74 1275 16 a a DT cord-015021-pol2qm74 1275 17 limited limited JJ cord-015021-pol2qm74 1275 18 period period NN cord-015021-pol2qm74 1275 19 of of IN cord-015021-pol2qm74 1275 20 rime rime NN cord-015021-pol2qm74 1275 21 . . . cord-015021-pol2qm74 1276 1 These these DT cord-015021-pol2qm74 1276 2 observations observation NNS cord-015021-pol2qm74 1276 3 will will MD cord-015021-pol2qm74 1276 4 have have VB cord-015021-pol2qm74 1276 5 to to TO cord-015021-pol2qm74 1276 6 be be VB cord-015021-pol2qm74 1276 7 confirmed confirm VBN cord-015021-pol2qm74 1276 8 in in IN cord-015021-pol2qm74 1276 9 carefully carefully RB cord-015021-pol2qm74 1276 10 designed design VBN cord-015021-pol2qm74 1276 11 clinical clinical JJ cord-015021-pol2qm74 1276 12 trials trial NNS cord-015021-pol2qm74 1276 13 . . . cord-015021-pol2qm74 1277 1 C C NNP cord-015021-pol2qm74 1277 2 , , , cord-015021-pol2qm74 1277 3 arbobydrams arbobydram NNS cord-015021-pol2qm74 1277 4 are be VBP cord-015021-pol2qm74 1277 5 ubiquizom ubiquizom JJ cord-015021-pol2qm74 1277 6 constir constir NNP cord-015021-pol2qm74 1278 1 ~uts ~uts NNP cord-015021-pol2qm74 1278 2 of of IN cord-015021-pol2qm74 1278 3 cell cell NN cord-015021-pol2qm74 1278 4 sv.rfaees sv.rfaee NNS cord-015021-pol2qm74 1278 5 , , , cord-015021-pol2qm74 1278 6 and and CC cord-015021-pol2qm74 1278 7 possess possess VBP cord-015021-pol2qm74 1278 8 many many JJ cord-015021-pol2qm74 1278 9 c c NN cord-015021-pol2qm74 1278 10 ~ ~ NFP cord-015021-pol2qm74 1278 11 xSsfies xSsfies NNP cord-015021-pol2qm74 1279 1 ttm~ ttm~ CD cord-015021-pol2qm74 1279 2 m~,e m~,e CD cord-015021-pol2qm74 1279 3 ~em ~em XX cord-015021-pol2qm74 1280 1 ide~. ide~. NNP cord-015021-pol2qm74 1280 2 canaidates canaidates NNPS cord-015021-pol2qm74 1280 3 for for IN cord-015021-pol2qm74 1280 4 r r NNP cord-015021-pol2qm74 1280 5 ~ ~ CD cord-015021-pol2qm74 1280 6 ognifioa ognifioa NNP cord-015021-pol2qm74 1280 7 mole mole NN cord-015021-pol2qm74 1280 8 ~ ~ NFP cord-015021-pol2qm74 1280 9 ule ule NNP cord-015021-pol2qm74 1280 10 & & CC cord-015021-pol2qm74 1281 1 In in IN cord-015021-pol2qm74 1281 2 m m NN cord-015021-pol2qm74 1282 1 ~y ~y NNP cord-015021-pol2qm74 1282 2 systems system NNS cord-015021-pol2qm74 1282 3 whe,~ whe,~ POS cord-015021-pol2qm74 1282 4 ceR cer JJ cord-015021-pol2qm74 1282 5 udhesioa udhesioa NNS cord-015021-pol2qm74 1283 1 ~lays ~lay NNS cord-015021-pol2qm74 1284 1 a a DT cord-015021-pol2qm74 1284 2 critical critical JJ cord-015021-pol2qm74 1284 3 ro~ ro~ JJ cord-015021-pol2qm74 1284 4 car car NN cord-015021-pol2qm74 1284 5 ~ ~ NFP cord-015021-pol2qm74 1284 6 hydram hydram NNP cord-015021-pol2qm74 1285 1 l:~dtag l:~dtag NNP cord-015021-pol2qm74 1285 2 ~otegas ~otegas NFP cord-015021-pol2qm74 1285 3 have have VBP cord-015021-pol2qm74 1285 4 been be VBN cord-015021-pol2qm74 1285 5 shown show VBN cord-015021-pol2qm74 1285 6 to to IN cord-015021-pol2qm74 1285 7 b b NN cord-015021-pol2qm74 1285 8 ~ ~ NFP cord-015021-pol2qm74 1285 9 ad ad NN cord-015021-pol2qm74 1285 10 tocell tocell NNP cord-015021-pol2qm74 1285 11 surfa~ surfa~ NNP cord-015021-pol2qm74 1285 12 earbohydzaxes earbohydzaxes NNP cord-015021-pol2qm74 1286 1 ~nd ~nd NNP cord-015021-pol2qm74 1287 1 pZrl pZrl NNP cord-015021-pol2qm74 1287 2 ~ ~ NFP cord-015021-pol2qm74 1287 3 pate pate NN cord-015021-pol2qm74 1287 4 in in IN cord-015021-pol2qm74 1287 5 cell cell NN cord-015021-pol2qm74 1287 6 - - HYPH cord-015021-pol2qm74 1287 7 ceil ceil NN cord-015021-pol2qm74 1287 8 Lumtaefion Lumtaefion NNP cord-015021-pol2qm74 1287 9 & & CC cord-015021-pol2qm74 1287 10 Such Such NNP cord-015021-pol2qm74 1287 11 sys,.ems sys,.ems NNPS cord-015021-pol2qm74 1287 12 include include VBP cord-015021-pol2qm74 1287 13 ~rti ~rti XX cord-015021-pol2qm74 1288 1 ~za ~za NNP cord-015021-pol2qm74 1288 2 ~ ~ NNP cord-015021-pol2qm74 1288 3 io= io= NNP cord-015021-pol2qm74 1288 4 , , , cord-015021-pol2qm74 1288 5 deveaopmeat deveaopmeat NNP cord-015021-pol2qm74 1288 6 , , , cord-015021-pol2qm74 1288 7 l l NNP cord-015021-pol2qm74 1288 8 ~ ~ NFP cord-015021-pol2qm74 1288 9 thoge~-hcet thoge~-hcet NNP cord-015021-pol2qm74 1288 10 reeog reeog NN cord-015021-pol2qm74 1288 11 -- -- : cord-015021-pol2qm74 1288 12 ition ition NN cord-015021-pol2qm74 1289 1 ~d ~d . cord-015021-pol2qm74 1290 1 i i PRP cord-015021-pol2qm74 1290 2 ~ ~ CD cord-015021-pol2qm74 1290 3 zmmadon zmmadon NNP cord-015021-pol2qm74 1290 4 _ _ NNP cord-015021-pol2qm74 1291 1 In in IN cord-015021-pol2qm74 1291 2 particular particular JJ cord-015021-pol2qm74 1291 3 , , , cord-015021-pol2qm74 1291 4 tb.z tb.z VBD cord-015021-pol2qm74 1291 5 recent recent JJ cord-015021-pol2qm74 1291 6 di%~ve~ di%~ve~ NN cord-015021-pol2qm74 1291 7 of of IN cord-015021-pol2qm74 1291 8 Lhe Lhe NNP cord-015021-pol2qm74 1291 9 selec~ selec~ NNP cord-015021-pol2qm74 1291 10 and and CC cord-015021-pol2qm74 1291 11 th~ th~ NNP cord-015021-pol2qm74 1291 12 impo.~a impo.~a NNP cord-015021-pol2qm74 1292 1 ~C~ ~C~ VBN cord-015021-pol2qm74 1292 2 in in IN cord-015021-pol2qm74 1292 3 teukccy~ teukccy~ NNP cord-015021-pol2qm74 1293 1 udo udo NNP cord-015021-pol2qm74 1293 2 ~ ~ NNP cord-015021-pol2qm74 1293 3 lelium lelium NNP cord-015021-pol2qm74 1293 4 adh adh NNP cord-015021-pol2qm74 1294 1 ~ion ~ion NNP cord-015021-pol2qm74 1294 2 has have VBZ cord-015021-pol2qm74 1294 3 -~f -~f CD cord-015021-pol2qm74 1295 1 ~M ~M NFP cord-015021-pol2qm74 1295 2 av.c av.c NNS cord-015021-pol2qm74 1295 3 ~ ~ NFP cord-015021-pol2qm74 1295 4 on on IN cord-015021-pol2qm74 1295 5 OK OK NNP cord-015021-pol2qm74 1295 6 l~ l~ XX cord-015021-pol2qm74 1296 1 in in IN cord-015021-pol2qm74 1296 2 m m NNP cord-015021-pol2qm74 1296 3 ~ ~ NNP cord-015021-pol2qm74 1296 4 ted ted NNP cord-015021-pol2qm74 1296 5 cell cell NN cord-015021-pol2qm74 1296 6 adhe adhe NNP cord-015021-pol2qm74 1296 7 ~ ~ NFP cord-015021-pol2qm74 1296 8 on on RB cord-015021-pol2qm74 1296 9 . . . cord-015021-pol2qm74 1297 1 S S NNP cord-015021-pol2qm74 1298 1 ~vere ~vere NNP cord-015021-pol2qm74 1298 2 / / SYM cord-015021-pol2qm74 1298 3 poten poten NNP cord-015021-pol2qm74 1298 4 ~ ~ NNP cord-015021-pol2qm74 1298 5 s s NN cord-015021-pol2qm74 1298 6 / / SYM cord-015021-pol2qm74 1298 7 cs.rbohydr~ cs.rbohydr~ NNP cord-015021-pol2qm74 1299 1 l l NNP cord-015021-pol2qm74 1299 2 ~ ~ NNP cord-015021-pol2qm74 1299 3 ga ga NNP cord-015021-pol2qm74 1299 4 ~ ~ NFP cord-015021-pol2qm74 1299 5 S S NNP cord-015021-pol2qm74 1299 6 hRve hrve ADD cord-015021-pol2qm74 1300 1 ~e ~e NNP cord-015021-pol2qm74 1301 1 ~l ~l NNP cord-015021-pol2qm74 1301 2 ~u ~u NFP cord-015021-pol2qm74 1301 3 ~ ~ NFP cord-015021-pol2qm74 1301 4 ilied ilie VBN cord-015021-pol2qm74 1301 5 for for IN cord-015021-pol2qm74 1301 6 ~he ~he NNP cord-015021-pol2qm74 1301 7 s s NNP cord-015021-pol2qm74 1301 8 ~ ~ NFP cord-015021-pol2qm74 1301 9 lcc lcc NNP cord-015021-pol2qm74 1301 10 ~ ~ NNP cord-015021-pol2qm74 1301 11 ins ins NNP cord-015021-pol2qm74 1301 12 . . . cord-015021-pol2qm74 1302 1 The,~ the,~ CD cord-015021-pol2qm74 1302 2 c c NNP cord-015021-pol2qm74 1303 1 ~u ~u NNP cord-015021-pol2qm74 1303 2 be be VB cord-015021-pol2qm74 1303 3 broadly broadly RB cord-015021-pol2qm74 1303 4 di,,Sded di,,sded JJ cord-015021-pol2qm74 1304 1 La La NNP cord-015021-pol2qm74 1305 1 ~o ~o NFP cord-015021-pol2qm74 1305 2 ~Wo ~Wo NFP cord-015021-pol2qm74 1305 3 m'oups m'oups NNP cord-015021-pol2qm74 1305 4 -sibyl -sibyl HYPH cord-015021-pol2qm74 1305 5 L L NNP cord-015021-pol2qm74 1306 1 ~wis ~wis NNP cord-015021-pol2qm74 1306 2 x x SYM cord-015021-pol2qm74 1306 3 m~ m~ XX cord-015021-pol2qm74 1306 4 mh~.~l mh~.~l '' cord-015021-pol2qm74 1307 1 Oligo Oligo NNP cord-015021-pol2qm74 1307 2 ~ ~ NFP cord-015021-pol2qm74 1307 3 chadd chadd NNP cord-015021-pol2qm74 1307 4 ~ ~ NFP cord-015021-pol2qm74 1307 5 s s NNP cord-015021-pol2qm74 1307 6 , , , cord-015021-pol2qm74 1308 1 ~d ~d . cord-015021-pol2qm74 1309 1 sf/~ sf/~ NNP cord-015021-pol2qm74 1309 2 ca~ ca~ NNP cord-015021-pol2qm74 1310 1 ohydmma ohydmma NNP cord-015021-pol2qm74 1310 2 , , , cord-015021-pol2qm74 1310 3 All all DT cord-015021-pol2qm74 1310 4 ~:~ ~:~ CD cord-015021-pol2qm74 1311 1 ~l ~l NNP cord-015021-pol2qm74 1312 1 ~dns ~dns NNP cord-015021-pol2qm74 1312 2 bind bind VB cord-015021-pol2qm74 1312 3 m m NN cord-015021-pol2qm74 1313 1 siflyl siflyl NNP cord-015021-pol2qm74 1313 2 L L NNP cord-015021-pol2qm74 1313 3 ~ ~ NNP cord-015021-pol2qm74 1313 4 wis wis NNP cord-015021-pol2qm74 1313 5 x x NNP cord-015021-pol2qm74 1313 6 ( ( -LRB- cord-015021-pol2qm74 1313 7 sie$ sie$ XX cord-015021-pol2qm74 1313 8 o!igos o!igos NNP cord-015021-pol2qm74 1313 9 ~ ~ NFP cord-015021-pol2qm74 1313 10 ccb.e.rkMs ccb.e.rkms XX cord-015021-pol2qm74 1313 11 , , , cord-015021-pol2qm74 1313 12 zlthou~ zlthou~ NNP cord-015021-pol2qm74 1313 13 w~ w~ NNP cord-015021-pol2qm74 1313 14 differing differ VBG cord-015021-pol2qm74 1313 15 avi~ avi~ CD cord-015021-pol2qm74 1314 1 Re~. re~. LS cord-015021-pol2qm74 1314 2 ' ' `` cord-015021-pol2qm74 1314 3 We -PRON- PRP cord-015021-pol2qm74 1314 4 have have VBP cord-015021-pol2qm74 1314 5 i~¢n i~¢n NNS cord-015021-pol2qm74 1314 6 ~ ~ NFP cord-015021-pol2qm74 1314 7 ed ed XX cord-015021-pol2qm74 1314 8 the the DT cord-015021-pol2qm74 1314 9 functional functional JJ cord-015021-pol2qm74 1314 10 g g NNP cord-015021-pol2qm74 1314 11 ~ ~ NFP cord-015021-pol2qm74 1314 12 oups oups NNP cord-015021-pol2qm74 1314 13 0a 0a NNP cord-015021-pol2qm74 1315 1 s s NNP cord-015021-pol2qm74 1315 2 ~ ~ CD cord-015021-pol2qm74 1315 3 ex ex NN cord-015021-pol2qm74 1315 4 ~n~ ~n~ XX cord-015021-pol2qm74 1316 1 med med NNP cord-015021-pol2qm74 1316 2 / / SYM cord-015021-pol2qm74 1316 3 a~ a~ : cord-015021-pol2qm74 1316 4 ~he ~he NNP cord-015021-pol2qm74 1317 1 b b LS cord-015021-pol2qm74 1317 2 ~ ~ NFP cord-015021-pol2qm74 1317 3 u u NNP cord-015021-pol2qm74 1317 4 ~di ~di NNP cord-015021-pol2qm74 1317 5 ~ ~ NFP cord-015021-pol2qm74 1317 6 g g NN cord-015021-pol2qm74 1317 7 of of IN cord-015021-pol2qm74 1317 8 ~h~ ~h~ ADD cord-015021-pol2qm74 1317 9 c c NN cord-015021-pol2qm74 1317 10 ~ ~ NFP cord-015021-pol2qm74 1317 11 b0hydmm b0hydmm NNP cord-015021-pol2qm74 1317 12 = = SYM cord-015021-pol2qm74 1317 13 E e NN cord-015021-pol2qm74 1317 14 - - HYPH cord-015021-pol2qm74 1317 15 Se se JJ cord-015021-pol2qm74 1317 16 / / SYM cord-015021-pol2qm74 1317 17 sedm sedm NNP cord-015021-pol2qm74 1318 1 We -PRON- PRP cord-015021-pol2qm74 1318 2 have have VBP cord-015021-pol2qm74 1318 3 used use VBN cord-015021-pol2qm74 1318 4 ~hat ~hat NNP cord-015021-pol2qm74 1318 5 iv.formation iv.formation NNP cord-015021-pol2qm74 1318 6 to to IN cord-015021-pol2qm74 1318 7 sya sya NNP cord-015021-pol2qm74 1318 8 ~ ~ NFP cord-015021-pol2qm74 1318 9 esize esize NNP cord-015021-pol2qm74 1318 10 sLe sLe NNP cord-015021-pol2qm74 1318 11 ~ ~ NFP cord-015021-pol2qm74 1318 12 ' ' '' cord-015021-pol2qm74 1318 13 ~mt0gs ~mt0gs NNP cord-015021-pol2qm74 1318 14 r.he r.he NNP cord-015021-pol2qm74 1318 15 , , , cord-015021-pol2qm74 1318 16 t t NNP cord-015021-pol2qm74 1318 17 focus focus NN cord-015021-pol2qm74 1318 18 on on IN cord-015021-pol2qm74 1318 19 replacing replace VBG cord-015021-pol2qm74 1318 20 sLslic sLslic NNP cord-015021-pol2qm74 1319 1 ~Sd ~Sd NFP cord-015021-pol2qm74 1320 1 ~nd ~nd NNP cord-015021-pol2qm74 1321 1 fuc0s¢ fuc0s¢ VBG cord-015021-pol2qm74 1321 2 wi~ wi~ RB cord-015021-pol2qm74 1321 3 simpler simple JJR cord-015021-pol2qm74 1321 4 , , , cord-015021-pol2qm74 1321 5 more more RBR cord-015021-pol2qm74 1321 6 stable stable JJ cord-015021-pol2qm74 1321 7 strunt strunt NN cord-015021-pol2qm74 1321 8 ~ ~ NFP cord-015021-pol2qm74 1321 9 es es XX cord-015021-pol2qm74 1321 10 . . . cord-015021-pol2qm74 1322 1 A[~ou A[~ou NNP cord-015021-pol2qm74 1323 1 ~a ~a NNS cord-015021-pol2qm74 1323 2 ~ ~ NFP cord-015021-pol2qm74 1323 3 proeer~ proeer~ NN cord-015021-pol2qm74 1323 4 is be VBZ cord-015021-pol2qm74 1323 5 ongoing ongoing JJ cord-015021-pol2qm74 1323 6 , , , cord-015021-pol2qm74 1323 7 we -PRON- PRP cord-015021-pol2qm74 1323 8 hve hve VBP cord-015021-pol2qm74 1323 9 been be VBN cord-015021-pol2qm74 1324 1 ~ucee,.~ful ~ucee,.~ful NFP cord-015021-pol2qm74 1325 1 a~ a~ : cord-015021-pol2qm74 1326 1 rep rep NNP cord-015021-pol2qm74 1326 2 ~ ~ NNP cord-015021-pol2qm74 1326 3 aein8 aein8 NNP cord-015021-pol2qm74 1327 1 t.ke t.ke NNP cord-015021-pol2qm74 1328 1 si si NNP cord-015021-pol2qm74 1328 2 ~ ~ NFP cord-015021-pol2qm74 1328 3 ic ic NNP cord-015021-pol2qm74 1328 4 a a NNP cord-015021-pol2qm74 1328 5 ~ ~ NFP cord-015021-pol2qm74 1328 6 id id NN cord-015021-pol2qm74 1328 7 . . . cord-015021-pol2qm74 1329 1 residue residue NNP cord-015021-pol2qm74 1329 2 wi~ wi~ NN cord-015021-pol2qm74 1329 3 std.fzte std.fzte NNP cord-015021-pol2qm74 1329 4 . . . cord-015021-pol2qm74 1330 1 ~ce~ ~ce~ NNP cord-015021-pol2qm74 1331 1 or or CC cord-015021-pol2qm74 1331 2 la la NNP cord-015021-pol2qm74 1332 1 ~c ~c NFP cord-015021-pol2qm74 1332 2 amd amd NNP cord-015021-pol2qm74 1332 3 groupa groupa NNP cord-015021-pol2qm74 1333 1 We -PRON- PRP cord-015021-pol2qm74 1333 2 t'we t'we NNP cord-015021-pol2qm74 1334 1 ex2aninad ex2aninad NNP cord-015021-pol2qm74 1334 2 & & CC cord-015021-pol2qm74 1334 3 e e NNP cord-015021-pol2qm74 1334 4 ten ten CD cord-015021-pol2qm74 1334 5 , , , cord-015021-pol2qm74 1334 6 bunion bunion NN cord-015021-pol2qm74 1334 7 of of IN cord-015021-pol2qm74 1334 8 ezed~ ezed~ NNP cord-015021-pol2qm74 1334 9 hydroxyl hydroxyl NN cord-015021-pol2qm74 1334 10 group group NN cord-015021-pol2qm74 1334 11 of of IN cord-015021-pol2qm74 1334 12 the the DT cord-015021-pol2qm74 1334 13 fizeose fizeose JJ cord-015021-pol2qm74 1334 14 residue residue NN cord-015021-pol2qm74 1334 15 ~ ~ NFP cord-015021-pol2qm74 1335 1 billding billding NN cord-015021-pol2qm74 1335 2 of of IN cord-015021-pol2qm74 1335 3 E- E- NNP cord-015021-pol2qm74 1335 4 , , , cord-015021-pol2qm74 1335 5 L-~nd l-~nd NN cord-015021-pol2qm74 1335 6 P p NN cord-015021-pol2qm74 1335 7 - - , cord-015021-pol2qm74 1335 8 SeleeS selee NNS cord-015021-pol2qm74 1335 9 .. .. . cord-015021-pol2qm74 1336 1 u. u. NNP cord-015021-pol2qm74 1337 1 We -PRON- PRP cord-015021-pol2qm74 1337 2 have have VBP cord-015021-pol2qm74 1337 3 also also RB cord-015021-pol2qm74 1337 4 found find VBN cord-015021-pol2qm74 1337 5 m m NNP cord-015021-pol2qm74 1337 6 ~ ~ CD cord-015021-pol2qm74 1337 7 fi fi NN cord-015021-pol2qm74 1337 8 ~ ~ NNP cord-015021-pol2qm74 1337 9 fio~ fio~ CD cord-015021-pol2qm74 1337 10 of of IN cord-015021-pol2qm74 1337 11 the the DT cord-015021-pol2qm74 1337 12 reducing reduce VBG cord-015021-pol2qm74 1337 13 end end NN cord-015021-pol2qm74 1338 1 ~¢.cha'i~ ~¢.cha'i~ NNP cord-015021-pol2qm74 1339 1 ~z ~z NFP cord-015021-pol2qm74 1339 2 increase increase VB cord-015021-pol2qm74 1339 3 mtagovSst mtagovsst CD cord-015021-pol2qm74 1339 4 activity activity NN cord-015021-pol2qm74 1339 5 . . . cord-015021-pol2qm74 1340 1 The the DT cord-015021-pol2qm74 1340 2 , , , cord-015021-pol2qm74 1340 3 M¢ond m¢ond NN cord-015021-pol2qm74 1340 4 . . . cord-015021-pol2qm74 1341 1 group group NN cord-015021-pol2qm74 1341 2 of of IN cord-015021-pol2qm74 1341 3 figs fig NNS cord-015021-pol2qm74 1341 4 , , , cord-015021-pol2qm74 1341 5 rids rid VBZ cord-015021-pol2qm74 1341 6 a. a. NN cord-015021-pol2qm74 1342 1 R R NNP cord-015021-pol2qm74 1342 2 eontzin eontzin NNP cord-015021-pol2qm74 1343 1 su su NNP cord-015021-pol2qm74 1344 1 ~a~ ~a~ NFP cord-015021-pol2qm74 1344 2 0u 0u CD cord-015021-pol2qm74 1345 1 a a DT cord-015021-pol2qm74 1345 2 ea.rbohydr ea.rbohydr NN cord-015021-pol2qm74 1345 3 ~ ~ NFP cord-015021-pol2qm74 1345 4 t¢ t¢ NN cord-015021-pol2qm74 1345 5 support support NN cord-015021-pol2qm74 1345 6 , , , cord-015021-pol2qm74 1345 7 , , , cord-015021-pol2qm74 1345 8 und und RB cord-015021-pol2qm74 1345 9 seem seem VB cord-015021-pol2qm74 1345 10 to to IN cord-015021-pol2qm74 1345 11 bi~.d bi~.d NNP cord-015021-pol2qm74 1345 12 to to TO cord-015021-pol2qm74 1345 13 t t VB cord-015021-pol2qm74 1346 1 ~e ~e NFP cord-015021-pol2qm74 1346 2 sele sele NNP cord-015021-pol2qm74 1346 3 ~ ~ NFP cord-015021-pol2qm74 1346 4 ti ti NNP cord-015021-pol2qm74 1346 5 ~ ~ NNP cord-015021-pol2qm74 1346 6 s s NNP cord-015021-pol2qm74 1347 1 wi~ wi~ NNP cord-015021-pol2qm74 1347 2 dLf dLf NNP cord-015021-pol2qm74 1347 3 : : : cord-015021-pol2qm74 1347 4 ferem ferem NNP cord-015021-pol2qm74 1347 5 characteristics characteristic NNS cord-015021-pol2qm74 1347 6 C0.an C0.an NNP cord-015021-pol2qm74 1347 7 does do VBZ cord-015021-pol2qm74 1347 8 sLe sle NN cord-015021-pol2qm74 1347 9 : : : cord-015021-pol2qm74 1347 10 , , , cord-015021-pol2qm74 1347 11 S s NN cord-015021-pol2qm74 1347 12 = = SYM cord-015021-pol2qm74 1347 13 h h NN cord-015021-pol2qm74 1347 14 compounds compound NNS cord-015021-pol2qm74 1347 15 are be VBP cord-015021-pol2qm74 1347 16 m2ogniz~ m2ogniz~ JJ cord-015021-pol2qm74 1348 1 d d NNP cord-015021-pol2qm74 1348 2 by by IN cord-015021-pol2qm74 1348 3 L L NNP cord-015021-pol2qm74 1348 4 - - HYPH cord-015021-pol2qm74 1348 5 Selects select NNS cord-015021-pol2qm74 1348 6 . . . cord-015021-pol2qm74 1349 1 md md NNP cord-015021-pol2qm74 1349 2 p p NNP cord-015021-pol2qm74 1349 3 - - HYPH cord-015021-pol2qm74 1349 4 Selectia Selectia NNP cord-015021-pol2qm74 1349 5 , , , cord-015021-pol2qm74 1349 6 bur bur NN cord-015021-pol2qm74 1349 7 . . NNP cord-015021-pol2qm74 1349 8 , , , cord-015021-pol2qm74 1349 9 in in IN cord-015021-pol2qm74 1349 10 genera/ genera/ NNP cord-015021-pol2qm74 1349 11 , , , cord-015021-pol2qm74 1349 12 not not RB cord-015021-pol2qm74 1349 13 E e NN cord-015021-pol2qm74 1349 14 , , , cord-015021-pol2qm74 1349 15 Selecti~ Selecti~ . cord-015021-pol2qm74 1349 16 These these DT cord-015021-pol2qm74 1349 17 dam dam NN cord-015021-pol2qm74 1349 18 may may NNP cord-015021-pol2qm74 1349 19 mdicam mdicam NNP cord-015021-pol2qm74 1350 1 r.hat r.hat DT cord-015021-pol2qm74 1350 2 L l NN cord-015021-pol2qm74 1350 3 - - : cord-015021-pol2qm74 1350 4 and and CC cord-015021-pol2qm74 1350 5 P p NN cord-015021-pol2qm74 1350 6 - - HYPH cord-015021-pol2qm74 1350 7 S~ S~ NNP cord-015021-pol2qm74 1351 1 ¢at~ ¢at~ NNP cord-015021-pol2qm74 1351 2 h h NNP cord-015021-pol2qm74 1352 1 ~d ~d NFP cord-015021-pol2qm74 1352 2 via via IN cord-015021-pol2qm74 1352 3 o o NN cord-015021-pol2qm74 1352 4 , , , cord-015021-pol2qm74 1352 5 second second JJ cord-015021-pol2qm74 1352 6 ~te ~te NNP cord-015021-pol2qm74 1352 7 thaz thaz NNP cord-015021-pol2qm74 1352 8 operates operate VBZ cord-015021-pol2qm74 1352 9 Lu~.ead Lu~.ead NNP cord-015021-pol2qm74 1352 10 of of IN cord-015021-pol2qm74 1352 11 , , , cord-015021-pol2qm74 1352 12 or or CC cord-015021-pol2qm74 1352 13 in in IN cord-015021-pol2qm74 1352 14 conjunction conjunction NN cord-015021-pol2qm74 1352 15 with with IN cord-015021-pol2qm74 1352 16 ~tc ~tc NNP cord-015021-pol2qm74 1353 1 sLe sLe NNS cord-015021-pol2qm74 1353 2 " " '' cord-015021-pol2qm74 1353 3 b b NN cord-015021-pol2qm74 1353 4 ~ ~ NFP cord-015021-pol2qm74 1353 5 ding ding NNP cord-015021-pol2qm74 1353 6 ~iite ~iite NNP cord-015021-pol2qm74 1353 7 . . . cord-015021-pol2qm74 1354 1 Dam Dam NNP cord-015021-pol2qm74 1354 2 rela~&~g rela~&~g NNP cord-015021-pol2qm74 1354 3 to to IN cord-015021-pol2qm74 1354 4 ±e ±e NNP cord-015021-pol2qm74 1354 5 , , , cord-015021-pol2qm74 1354 6 se se NNP cord-015021-pol2qm74 1354 7 two two CD cord-015021-pol2qm74 1354 8 types type NNS cord-015021-pol2qm74 1354 9 of of IN cord-015021-pol2qm74 1354 10 , , , cord-015021-pol2qm74 1354 11 ml~ ml~ NNP cord-015021-pol2qm74 1354 12 liga liga NNP cord-015021-pol2qm74 1355 1 ~ds ~ds NNP cord-015021-pol2qm74 1355 2 have have VBP cord-015021-pol2qm74 1355 3 beam beam NN cord-015021-pol2qm74 1355 4 t t NN cord-015021-pol2qm74 1356 1 ~ed ~ed NNP cord-015021-pol2qm74 1356 2 to to IN cord-015021-pol2qm74 1356 3 desig~ desig~ NNP cord-015021-pol2qm74 1356 4 potential potential JJ cord-015021-pol2qm74 1356 5 the2~peutics the2~peutic NNS cord-015021-pol2qm74 1356 6 for for IN cord-015021-pol2qm74 1356 7 i i PRP cord-015021-pol2qm74 1356 8 ~ ~ CD cord-015021-pol2qm74 1356 9 fi fi NN cord-015021-pol2qm74 1356 10 ~ ~ NFP cord-015021-pol2qm74 1356 11 anmat0ry anmat0ry NNP cord-015021-pol2qm74 1356 12 disease disease NN cord-015021-pol2qm74 1356 13 . . . cord-015021-pol2qm74 1357 1 Lr Lr NNP cord-015021-pol2qm74 1357 2 : : : cord-015021-pol2qm74 1357 3 rng rng NNP cord-015021-pol2qm74 1357 4 maimaI maimaI NNP cord-015021-pol2qm74 1357 5 models model NNS cord-015021-pol2qm74 1357 6 of of IN cord-015021-pol2qm74 1357 7 acute acute JJ cord-015021-pol2qm74 1357 8 lung lung NN cord-015021-pol2qm74 1357 9 Lu3ury Lu3ury NNP cord-015021-pol2qm74 1357 10 we -PRON- PRP cord-015021-pol2qm74 1357 11 can can MD cord-015021-pol2qm74 1357 12 demo demo VB cord-015021-pol2qm74 1357 13 ~ ~ NFP cord-015021-pol2qm74 1357 14 trate trate NNP cord-015021-pol2qm74 1357 15 that that DT cord-015021-pol2qm74 1357 16 eompmmds eompmmds NNP cord-015021-pol2qm74 1357 17 that that WDT cord-015021-pol2qm74 1357 18 inhibit inhibit NNP cord-015021-pol2qm74 1357 19 seleetiu seleetiu NNP cord-015021-pol2qm74 1357 20 birding birding NN cord-015021-pol2qm74 1358 1 ~ ~ NFP cord-015021-pol2qm74 1358 2 ~i~ ~i~ NFP cord-015021-pol2qm74 1359 1 o o UH cord-015021-pol2qm74 1359 2 hzve hzve NNP cord-015021-pol2qm74 1359 3 ber ber NNP cord-015021-pol2qm74 1359 4 ~ ~ NFP cord-015021-pol2qm74 1359 5 ficial ficial JJ cord-015021-pol2qm74 1359 6 effects effect NNS cord-015021-pol2qm74 1359 7 when when WRB cord-015021-pol2qm74 1359 8 uc uc NNP cord-015021-pol2qm74 1359 9 ~ ~ NNP cord-015021-pol2qm74 1359 10 d d NNP cord-015021-pol2qm74 1359 11 in in IN cord-015021-pol2qm74 1359 12 rive rive NNP cord-015021-pol2qm74 1359 13 . . . cord-015021-pol2qm74 1360 1 Progressive progressive JJ cord-015021-pol2qm74 1360 2 microvascular microvascular JJ cord-015021-pol2qm74 1360 3 damage damage NN cord-015021-pol2qm74 1360 4 in in IN cord-015021-pol2qm74 1360 5 the the DT cord-015021-pol2qm74 1360 6 tissue tissue NN cord-015021-pol2qm74 1361 1 adjacent adjacent JJ cord-015021-pol2qm74 1361 2 to to IN cord-015021-pol2qm74 1361 3 a a DT cord-015021-pol2qm74 1361 4 cutaneous cutaneous JJ cord-015021-pol2qm74 1361 5 burn burn NN cord-015021-pol2qm74 1361 6 injury injury NN cord-015021-pol2qm74 1361 7 results result NNS cord-015021-pol2qm74 1361 8 in in IN cord-015021-pol2qm74 1361 9 extension extension NN cord-015021-pol2qm74 1361 10 of of IN cord-015021-pol2qm74 1361 11 burn burn NN cord-015021-pol2qm74 1361 12 size size NN cord-015021-pol2qm74 1361 13 . . . cord-015021-pol2qm74 1362 1 The the DT cord-015021-pol2qm74 1362 2 role role NN cord-015021-pol2qm74 1362 3 of of IN cord-015021-pol2qm74 1362 4 leukocytes leukocyte NNS cord-015021-pol2qm74 1362 5 in in IN cord-015021-pol2qm74 1362 6 the the DT cord-015021-pol2qm74 1362 7 pathogenesis pathogenesis NN cord-015021-pol2qm74 1362 8 of of IN cord-015021-pol2qm74 1362 9 microvascular microvascular JJ cord-015021-pol2qm74 1362 10 injury injury NN cord-015021-pol2qm74 1362 11 was be VBD cord-015021-pol2qm74 1362 12 investigated investigate VBN cord-015021-pol2qm74 1362 13 by by IN cord-015021-pol2qm74 1362 14 inhibition inhibition NN cord-015021-pol2qm74 1362 15 of of IN cord-015021-pol2qm74 1362 16 their -PRON- PRP$ cord-015021-pol2qm74 1362 17 adherence adherence NN cord-015021-pol2qm74 1362 18 to to IN cord-015021-pol2qm74 1362 19 the the DT cord-015021-pol2qm74 1362 20 microvascular microvascular JJ cord-015021-pol2qm74 1362 21 endothelium endothelium NN cord-015021-pol2qm74 1362 22 using use VBG cord-015021-pol2qm74 1362 23 monoclonal monoclonal JJ cord-015021-pol2qm74 1362 24 antibodies antibody NNS cord-015021-pol2qm74 1362 25 directed direct VBN cord-015021-pol2qm74 1362 26 to to IN cord-015021-pol2qm74 1362 27 leukocyte leukocyte VB cord-015021-pol2qm74 1362 28 CDI CDI NNP cord-015021-pol2qm74 1362 29 8 8 CD cord-015021-pol2qm74 1362 30 or or CC cord-015021-pol2qm74 1362 31 its -PRON- PRP$ cord-015021-pol2qm74 1362 32 endothelial endothelial JJ cord-015021-pol2qm74 1362 33 ligaud ligaud NN cord-015021-pol2qm74 1362 34 , , , cord-015021-pol2qm74 1362 35 intercellular intercellular JJ cord-015021-pol2qm74 1362 36 adhesion adhesion NN cord-015021-pol2qm74 1362 37 molecule-1 molecule-1 NN cord-015021-pol2qm74 1363 1 ( ( -LRB- cord-015021-pol2qm74 1363 2 ICAM-1 ICAM-1 NNP cord-015021-pol2qm74 1363 3 , , , cord-015021-pol2qm74 1363 4 CD54 CD54 NNP cord-015021-pol2qm74 1363 5 ) ) -RRB- cord-015021-pol2qm74 1363 6 . . . cord-015021-pol2qm74 1364 1 A a DT cord-015021-pol2qm74 1364 2 model model NN cord-015021-pol2qm74 1364 3 of of IN cord-015021-pol2qm74 1364 4 thermal thermal JJ cord-015021-pol2qm74 1364 5 injury injury NN cord-015021-pol2qm74 1364 6 was be VBD cord-015021-pol2qm74 1364 7 developed develop VBN cord-015021-pol2qm74 1364 8 using use VBG cord-015021-pol2qm74 1364 9 New New NNP cord-015021-pol2qm74 1364 10 Zealand Zealand NNP cord-015021-pol2qm74 1364 11 White white JJ cord-015021-pol2qm74 1364 12 rabbits rabbit NNS cord-015021-pol2qm74 1364 13 . . . cord-015021-pol2qm74 1365 1 Two two CD cord-015021-pol2qm74 1365 2 sets set NNS cord-015021-pol2qm74 1365 3 of of IN cord-015021-pol2qm74 1365 4 three three CD cord-015021-pol2qm74 1365 5 full full JJ cord-015021-pol2qm74 1365 6 - - HYPH cord-015021-pol2qm74 1365 7 thickness thickness NN cord-015021-pol2qm74 1365 8 burns burn NNS cord-015021-pol2qm74 1365 9 separated separate VBN cord-015021-pol2qm74 1365 10 by by IN cord-015021-pol2qm74 1365 11 two two CD cord-015021-pol2qm74 1365 12 5 5 CD cord-015021-pol2qm74 1365 13 x x SYM cord-015021-pol2qm74 1365 14 30-mm 30-mm CD cord-015021-pol2qm74 1365 15 zones zone NNS cord-015021-pol2qm74 1365 16 were be VBD cord-015021-pol2qm74 1365 17 produced produce VBN cord-015021-pol2qm74 1365 18 by by IN cord-015021-pol2qm74 1365 19 applying apply VBG cord-015021-pol2qm74 1365 20 brass brass NN cord-015021-pol2qm74 1365 21 probes probe NNS cord-015021-pol2qm74 1365 22 heated heat VBN cord-015021-pol2qm74 1365 23 to to IN cord-015021-pol2qm74 1365 24 100 100 CD cord-015021-pol2qm74 1365 25 ° ° NN cord-015021-pol2qm74 1365 26 C c NN cord-015021-pol2qm74 1365 27 to to IN cord-015021-pol2qm74 1365 28 the the DT cord-015021-pol2qm74 1365 29 animals animal NNS cord-015021-pol2qm74 1365 30 ' ' POS cord-015021-pol2qm74 1365 31 backs back NNS cord-015021-pol2qm74 1365 32 for for IN cord-015021-pol2qm74 1365 33 30 30 CD cord-015021-pol2qm74 1365 34 sec sec NNP cord-015021-pol2qm74 1365 35 . . . cord-015021-pol2qm74 1366 1 Cutaneous cutaneous JJ cord-015021-pol2qm74 1366 2 blood blood NN cord-015021-pol2qm74 1366 3 flow flow NN cord-015021-pol2qm74 1366 4 determinations determination NNS cord-015021-pol2qm74 1366 5 carried carry VBN cord-015021-pol2qm74 1366 6 out out RP cord-015021-pol2qm74 1366 7 with with IN cord-015021-pol2qm74 1366 8 a a DT cord-015021-pol2qm74 1366 9 laser laser NN cord-015021-pol2qm74 1366 10 doppler doppler NN cord-015021-pol2qm74 1366 11 blood blood NN cord-015021-pol2qm74 1366 12 flowmeter flowmeter NN cord-015021-pol2qm74 1366 13 were be VBD cord-015021-pol2qm74 1366 14 obtained obtain VBN cord-015021-pol2qm74 1366 15 for for IN cord-015021-pol2qm74 1366 16 72 72 CD cord-015021-pol2qm74 1366 17 hours hour NNS cord-015021-pol2qm74 1366 18 . . . cord-015021-pol2qm74 1367 1 There there EX cord-015021-pol2qm74 1367 2 were be VBD cord-015021-pol2qm74 1367 3 five five CD cord-015021-pol2qm74 1367 4 experimental experimental JJ cord-015021-pol2qm74 1367 5 groups group NNS cord-015021-pol2qm74 1367 6 : : : cord-015021-pol2qm74 1367 7 controls control NNS cord-015021-pol2qm74 1367 8 given give VBN cord-015021-pol2qm74 1367 9 saline saline NN cord-015021-pol2qm74 1367 10 alone alone RB cord-015021-pol2qm74 1367 11 ; ; : cord-015021-pol2qm74 1367 12 animals animal NNS cord-015021-pol2qm74 1367 13 given give VBN cord-015021-pol2qm74 1367 14 monoelonal monoelonal JJ cord-015021-pol2qm74 1367 15 antibody antibody NN cord-015021-pol2qm74 1367 16 to to IN cord-015021-pol2qm74 1367 17 the the DT cord-015021-pol2qm74 1367 18 CD CD NNP cord-015021-pol2qm74 1367 19 18 18 CD cord-015021-pol2qm74 1367 20 R r NN cord-015021-pol2qm74 1367 21 15.7 15.7 CD cord-015021-pol2qm74 1367 22 prior prior RB cord-015021-pol2qm74 1367 23 to to TO cord-015021-pol2qm74 1367 24 burn burn VB cord-015021-pol2qm74 1367 25 injury injury NN cord-015021-pol2qm74 1367 26 ( ( -LRB- cord-015021-pol2qm74 1367 27 pre pre JJ cord-015021-pol2qm74 1367 28 - - JJ cord-015021-pol2qm74 1367 29 R R NNP cord-015021-pol2qm74 1367 30 15.7 15.7 CD cord-015021-pol2qm74 1367 31 ) ) -RRB- cord-015021-pol2qm74 1367 32 ; ; : cord-015021-pol2qm74 1367 33 animals animal NNS cord-015021-pol2qm74 1367 34 given give VBN cord-015021-pol2qm74 1367 35 R R NNP cord-015021-pol2qm74 1367 36 15.7 15.7 CD cord-015021-pol2qm74 1367 37 30 30 CD cord-015021-pol2qm74 1367 38 min min NN cord-015021-pol2qm74 1367 39 after after IN cord-015021-pol2qm74 1367 40 burn burn NN cord-015021-pol2qm74 1367 41 injury injury NN cord-015021-pol2qm74 1367 42 ( ( -LRB- cord-015021-pol2qm74 1367 43 post post NN cord-015021-pol2qm74 1367 44 - - JJ cord-015021-pol2qm74 1367 45 R r JJ cord-015021-pol2qm74 1367 46 15.7 15.7 CD cord-015021-pol2qm74 1367 47 ) ) -RRB- cord-015021-pol2qm74 1367 48 ; ; : cord-015021-pol2qm74 1367 49 animals animal NNS cord-015021-pol2qm74 1367 50 given give VBN cord-015021-pol2qm74 1367 51 a a DT cord-015021-pol2qm74 1367 52 monoclonal monoclonal JJ cord-015021-pol2qm74 1367 53 antibody antibody NN cord-015021-pol2qm74 1367 54 to to IN cord-015021-pol2qm74 1367 55 ICAM ICAM NNP cord-015021-pol2qm74 1367 56 - - HYPH cord-015021-pol2qm74 1367 57 I I NNP cord-015021-pol2qm74 1367 58 , , , cord-015021-pol2qm74 1367 59 R R NNP cord-015021-pol2qm74 1367 60 6.5 6.5 CD cord-015021-pol2qm74 1367 61 prior prior RB cord-015021-pol2qm74 1367 62 to to TO cord-015021-pol2qm74 1367 63 burn burn VB cord-015021-pol2qm74 1367 64 ( ( -LRB- cord-015021-pol2qm74 1367 65 pre pre VB cord-015021-pol2qm74 1367 66 - - JJ cord-015021-pol2qm74 1367 67 R R NNP cord-015021-pol2qm74 1367 68 6.5 6.5 CD cord-015021-pol2qm74 1367 69 ) ) -RRB- cord-015021-pol2qm74 1367 70 ; ; : cord-015021-pol2qm74 1367 71 and and CC cord-015021-pol2qm74 1367 72 animals animal NNS cord-015021-pol2qm74 1367 73 given give VBN cord-015021-pol2qm74 1367 74 the the DT cord-015021-pol2qm74 1367 75 R R NNP cord-015021-pol2qm74 1367 76 6.5 6.5 CD cord-015021-pol2qm74 1367 77 30 30 CD cord-015021-pol2qm74 1367 78 min min NN cord-015021-pol2qm74 1367 79 postburn postburn NN cord-015021-pol2qm74 1367 80 injury injury NN cord-015021-pol2qm74 1367 81 ( ( -LRB- cord-015021-pol2qm74 1367 82 post post NN cord-015021-pol2qm74 1367 83 - - JJ cord-015021-pol2qm74 1367 84 R R NNP cord-015021-pol2qm74 1367 85 6.5 6.5 CD cord-015021-pol2qm74 1367 86 ) ) -RRB- cord-015021-pol2qm74 1367 87 . . . cord-015021-pol2qm74 1368 1 Blood blood NN cord-015021-pol2qm74 1368 2 flow flow NN cord-015021-pol2qm74 1368 3 in in IN cord-015021-pol2qm74 1368 4 the the DT cord-015021-pol2qm74 1368 5 marginal marginal JJ cord-015021-pol2qm74 1368 6 " " `` cord-015021-pol2qm74 1368 7 zone zone NN cord-015021-pol2qm74 1368 8 of of IN cord-015021-pol2qm74 1368 9 stasis stasis NN cord-015021-pol2qm74 1368 10 " " '' cord-015021-pol2qm74 1368 11 between between IN cord-015021-pol2qm74 1368 12 burn burn NN cord-015021-pol2qm74 1368 13 contact contact NN cord-015021-pol2qm74 1368 14 sites site NNS cord-015021-pol2qm74 1368 15 was be VBD cord-015021-pol2qm74 1368 16 significantly significantly RB cord-015021-pol2qm74 1368 17 higher high JJR cord-015021-pol2qm74 1368 18 in in IN cord-015021-pol2qm74 1368 19 the the DT cord-015021-pol2qm74 1368 20 antibody antibody NN cord-015021-pol2qm74 1368 21 - - HYPH cord-015021-pol2qm74 1368 22 treated treat VBN cord-015021-pol2qm74 1368 23 animals animal NNS cord-015021-pol2qm74 1368 24 . . . cord-015021-pol2qm74 1369 1 Administration administration NN cord-015021-pol2qm74 1369 2 of of IN cord-015021-pol2qm74 1369 3 the the DT cord-015021-pol2qm74 1369 4 antibodies antibody NNS cord-015021-pol2qm74 1369 5 30 30 CD cord-015021-pol2qm74 1369 6 min min NN cord-015021-pol2qm74 1369 7 after after IN cord-015021-pol2qm74 1369 8 injury injury NN cord-015021-pol2qm74 1369 9 was be VBD cord-015021-pol2qm74 1369 10 as as RB cord-015021-pol2qm74 1369 11 effective effective JJ cord-015021-pol2qm74 1369 12 as as IN cord-015021-pol2qm74 1369 13 preburn preburn NNP cord-015021-pol2qm74 1369 14 administration administration NN cord-015021-pol2qm74 1369 15 in in IN cord-015021-pol2qm74 1369 16 preserving preserve VBG cord-015021-pol2qm74 1369 17 blood blood NN cord-015021-pol2qm74 1369 18 flow flow NN cord-015021-pol2qm74 1369 19 . . . cord-015021-pol2qm74 1370 1 At at IN cord-015021-pol2qm74 1370 2 72 72 CD cord-015021-pol2qm74 1370 3 hr hr NN cord-015021-pol2qm74 1370 4 post post NN cord-015021-pol2qm74 1370 5 - - JJ cord-015021-pol2qm74 1370 6 burn burn VB cord-015021-pol2qm74 1371 1 all all DT cord-015021-pol2qm74 1371 2 antibody antibody NN cord-015021-pol2qm74 1371 3 -treated -treate VBD cord-015021-pol2qm74 1371 4 animals animal NNS cord-015021-pol2qm74 1371 5 had have VBD cord-015021-pol2qm74 1371 6 blood blood NN cord-015021-pol2qm74 1371 7 flow flow NN cord-015021-pol2qm74 1371 8 in in IN cord-015021-pol2qm74 1371 9 the the DT cord-015021-pol2qm74 1371 10 areas area NNS cord-015021-pol2qm74 1371 11 at at IN cord-015021-pol2qm74 1371 12 risk risk NN cord-015021-pol2qm74 1371 13 for for IN cord-015021-pol2qm74 1371 14 progression progression NN cord-015021-pol2qm74 1371 15 ( ( -LRB- cord-015021-pol2qm74 1371 16 i.e. i.e. FW cord-015021-pol2qm74 1371 17 , , , cord-015021-pol2qm74 1371 18 the the DT cord-015021-pol2qm74 1371 19 zone zone NN cord-015021-pol2qm74 1371 20 of of IN cord-015021-pol2qm74 1371 21 stasis stasis NN cord-015021-pol2qm74 1371 22 ) ) -RRB- cord-015021-pol2qm74 1371 23 at at IN cord-015021-pol2qm74 1371 24 or or CC cord-015021-pol2qm74 1371 25 above above IN cord-015021-pol2qm74 1371 26 baseline baseline JJ cord-015021-pol2qm74 1371 27 levels level NNS cord-015021-pol2qm74 1371 28 while while IN cord-015021-pol2qm74 1371 29 the the DT cord-015021-pol2qm74 1371 30 control control NN cord-015021-pol2qm74 1371 31 animals animal NNS cord-015021-pol2qm74 1371 32 had have VBD cord-015021-pol2qm74 1371 33 levels level NNS cord-015021-pol2qm74 1371 34 equal equal JJ cord-015021-pol2qm74 1371 35 to to IN cord-015021-pol2qm74 1371 36 34.7 34.7 CD cord-015021-pol2qm74 1371 37 _ _ NN cord-015021-pol2qm74 1371 38 + + CC cord-015021-pol2qm74 1372 1 12 12 CD cord-015021-pol2qm74 1372 2 % % NN cord-015021-pol2qm74 1372 3 of of IN cord-015021-pol2qm74 1372 4 baseline baseline NN cord-015021-pol2qm74 1372 5 ( ( -LRB- cord-015021-pol2qm74 1372 6 P p NN cord-015021-pol2qm74 1372 7 < < XX cord-015021-pol2qm74 1372 8 0.05 0.05 CD cord-015021-pol2qm74 1372 9 by by IN cord-015021-pol2qm74 1372 10 analysis analysis NN cord-015021-pol2qm74 1372 11 of of IN cord-015021-pol2qm74 1372 12 variance variance NN cord-015021-pol2qm74 1372 13 and and CC cord-015021-pol2qm74 1372 14 Mann Mann NNP cord-015021-pol2qm74 1372 15 - - HYPH cord-015021-pol2qm74 1372 16 Whitney Whitney NNP cord-015021-pol2qm74 1372 17 U U NNP cord-015021-pol2qm74 1372 18 test test NN cord-015021-pol2qm74 1372 19 ) ) -RRB- cord-015021-pol2qm74 1372 20 . . . cord-015021-pol2qm74 1373 1 These these DT cord-015021-pol2qm74 1373 2 results result NNS cord-015021-pol2qm74 1373 3 indicate indicate VBP cord-015021-pol2qm74 1373 4 that that IN cord-015021-pol2qm74 1373 5 leukocytes leukocyte NNS cord-015021-pol2qm74 1373 6 play play VBP cord-015021-pol2qm74 1373 7 an an DT cord-015021-pol2qm74 1373 8 important important JJ cord-015021-pol2qm74 1373 9 role role NN cord-015021-pol2qm74 1373 10 in in IN cord-015021-pol2qm74 1373 11 the the DT cord-015021-pol2qm74 1373 12 pathogenesis pathogenesis NN cord-015021-pol2qm74 1373 13 of of IN cord-015021-pol2qm74 1373 14 burn burn NN cord-015021-pol2qm74 1373 15 wound wound NN cord-015021-pol2qm74 1373 16 progression progression NN cord-015021-pol2qm74 1373 17 , , , cord-015021-pol2qm74 1373 18 and and CC cord-015021-pol2qm74 1373 19 that that IN cord-015021-pol2qm74 1373 20 this this DT cord-015021-pol2qm74 1373 21 progression progression NN cord-015021-pol2qm74 1373 22 can can MD cord-015021-pol2qm74 1373 23 be be VB cord-015021-pol2qm74 1373 24 attenuated attenuate VBN cord-015021-pol2qm74 1373 25 by by IN cord-015021-pol2qm74 1373 26 moduIating moduiate VBG cord-015021-pol2qm74 1373 27 adherence adherence NN cord-015021-pol2qm74 1373 28 to to IN cord-015021-pol2qm74 1373 29 endothelial endothelial JJ cord-015021-pol2qm74 1373 30 cells cell NNS cord-015021-pol2qm74 1373 31 . . . cord-015021-pol2qm74 1374 1 A a DT cord-015021-pol2qm74 1374 2 wealth wealth NN cord-015021-pol2qm74 1374 3 of of IN cord-015021-pol2qm74 1374 4 information information NN cord-015021-pol2qm74 1374 5 now now RB cord-015021-pol2qm74 1374 6 supports support VBZ cord-015021-pol2qm74 1374 7 the the DT cord-015021-pol2qm74 1374 8 hypothesis hypothesis NN cord-015021-pol2qm74 1374 9 that that DT cord-015021-pol2qm74 1374 10 inhibition inhibition NN cord-015021-pol2qm74 1374 11 of of IN cord-015021-pol2qm74 1374 12 cell cell NN cord-015021-pol2qm74 1374 13 adhesive adhesive NN cord-015021-pol2qm74 1374 14 mechanisms mechanism NNS cord-015021-pol2qm74 1374 15 will will MD cord-015021-pol2qm74 1374 16 Nter Nter NNP cord-015021-pol2qm74 1374 17 the the DT cord-015021-pol2qm74 1374 18 course course NN cord-015021-pol2qm74 1374 19 of of IN cord-015021-pol2qm74 1374 20 immunologicand immunologicand JJ cord-015021-pol2qm74 1374 21 inflammatory inflammatory JJ cord-015021-pol2qm74 1374 22 processes process NNS cord-015021-pol2qm74 1374 23 . . . cord-015021-pol2qm74 1375 1 What what WP cord-015021-pol2qm74 1375 2 remains remain VBZ cord-015021-pol2qm74 1375 3 unclear unclear JJ cord-015021-pol2qm74 1375 4 is be VBZ cord-015021-pol2qm74 1375 5 whether whether IN cord-015021-pol2qm74 1375 6 inhibition inhibition NN cord-015021-pol2qm74 1375 7 of of IN cord-015021-pol2qm74 1375 8 specific specific JJ cord-015021-pol2qm74 1375 9 mechanisms mechanism NNS cord-015021-pol2qm74 1375 10 wfl wfl NNP cord-015021-pol2qm74 1375 11 [ [ -LRB- cord-015021-pol2qm74 1375 12 be be VB cord-015021-pol2qm74 1375 13 of of IN cord-015021-pol2qm74 1375 14 therapeutic therapeutic JJ cord-015021-pol2qm74 1375 15 benefit benefit NN cord-015021-pol2qm74 1375 16 in in IN cord-015021-pol2qm74 1375 17 any any DT cord-015021-pol2qm74 1375 18 specific specific JJ cord-015021-pol2qm74 1375 19 human human JJ cord-015021-pol2qm74 1375 20 disease disease NN cord-015021-pol2qm74 1375 21 . . . cord-015021-pol2qm74 1376 1 Current current JJ cord-015021-pol2qm74 1376 2 data datum NNS cord-015021-pol2qm74 1376 3 derived derive VBN cord-015021-pol2qm74 1376 4 from from IN cord-015021-pol2qm74 1376 5 animal animal NN cord-015021-pol2qm74 1376 6 models model NNS cord-015021-pol2qm74 1376 7 are be VBP cord-015021-pol2qm74 1376 8 not not RB cord-015021-pol2qm74 1376 9 inconsistent inconsistent JJ cord-015021-pol2qm74 1376 10 with with IN cord-015021-pol2qm74 1376 11 the the DT cord-015021-pol2qm74 1376 12 hope hope NN cord-015021-pol2qm74 1376 13 of of IN cord-015021-pol2qm74 1376 14 therapeutic therapeutic JJ cord-015021-pol2qm74 1376 15 benefit benefit NN cord-015021-pol2qm74 1376 16 , , , cord-015021-pol2qm74 1376 17 but but CC cord-015021-pol2qm74 1376 18 techniques technique NNS cord-015021-pol2qm74 1376 19 for for IN cord-015021-pol2qm74 1376 20 inhibition inhibition NN cord-015021-pol2qm74 1376 21 ( ( -LRB- cord-015021-pol2qm74 1376 22 e.g. e.g. RB cord-015021-pol2qm74 1376 23 , , , cord-015021-pol2qm74 1376 24 antibodies antibody NNS cord-015021-pol2qm74 1376 25 , , , cord-015021-pol2qm74 1376 26 antisense antisense NN cord-015021-pol2qm74 1376 27 oligonucleotides oligonucleotide NNS cord-015021-pol2qm74 1376 28 , , , cord-015021-pol2qm74 1376 29 inhibitory inhibitory JJ cord-015021-pol2qm74 1376 30 peptides peptide NNS cord-015021-pol2qm74 1376 31 , , , cord-015021-pol2qm74 1376 32 inhibitory inhibitory JJ cord-015021-pol2qm74 1376 33 carbohydrates carbohydrate NNS cord-015021-pol2qm74 1376 34 , , , cord-015021-pol2qm74 1376 35 smaII smaii JJ cord-015021-pol2qm74 1376 36 synthetic synthetic JJ cord-015021-pol2qm74 1376 37 inhibitors inhibitor NNS cord-015021-pol2qm74 1376 38 , , , cord-015021-pol2qm74 1376 39 etc etc FW cord-015021-pol2qm74 1376 40 ) ) -RRB- cord-015021-pol2qm74 1376 41 , , , cord-015021-pol2qm74 1376 42 tissue tissue NN cord-015021-pol2qm74 1376 43 and and CC cord-015021-pol2qm74 1376 44 species species NN cord-015021-pol2qm74 1376 45 differences difference NNS cord-015021-pol2qm74 1376 46 in in IN cord-015021-pol2qm74 1376 47 the the DT cord-015021-pol2qm74 1376 48 relative relative JJ cord-015021-pol2qm74 1376 49 contributions contribution NNS cord-015021-pol2qm74 1376 50 of of IN cord-015021-pol2qm74 1376 51 adhesion adhesion NN cord-015021-pol2qm74 1376 52 molecules molecule NNS cord-015021-pol2qm74 1376 53 to to IN cord-015021-pol2qm74 1376 54 the the DT cord-015021-pol2qm74 1376 55 inflammatory inflammatory JJ cord-015021-pol2qm74 1376 56 process process NN cord-015021-pol2qm74 1376 57 , , , cord-015021-pol2qm74 1376 58 and and CC cord-015021-pol2qm74 1376 59 the the DT cord-015021-pol2qm74 1376 60 casCade casCade NNP cord-015021-pol2qm74 1376 61 model model NN cord-015021-pol2qm74 1376 62 of of IN cord-015021-pol2qm74 1376 63 adhesive adhesive JJ cord-015021-pol2qm74 1376 64 interactions interaction NNS cord-015021-pol2qm74 1376 65 are be VBP cord-015021-pol2qm74 1376 66 all all DT cord-015021-pol2qm74 1376 67 confounding confound VBG cord-015021-pol2qm74 1376 68 issues issue NNS cord-015021-pol2qm74 1376 69 , , , cord-015021-pol2qm74 1376 70 making make VBG cord-015021-pol2qm74 1376 71 predictions prediction NNS cord-015021-pol2qm74 1376 72 of of IN cord-015021-pol2qm74 1376 73 therapeutic therapeutic JJ cord-015021-pol2qm74 1376 74 benefit benefit NN cord-015021-pol2qm74 1376 75 in in IN cord-015021-pol2qm74 1376 76 any any DT cord-015021-pol2qm74 1376 77 specific specific JJ cord-015021-pol2qm74 1376 78 human human JJ cord-015021-pol2qm74 1376 79 disease disease NN cord-015021-pol2qm74 1376 80 process process NN cord-015021-pol2qm74 1376 81 very very RB cord-015021-pol2qm74 1376 82 difficult difficult JJ cord-015021-pol2qm74 1376 83 . . . cord-015021-pol2qm74 1377 1 Additional additional JJ cord-015021-pol2qm74 1377 2 concerns concern NNS cord-015021-pol2qm74 1377 3 involve involve VBP cord-015021-pol2qm74 1377 4 the the DT cord-015021-pol2qm74 1377 5 potential potential JJ cord-015021-pol2qm74 1377 6 roles role NNS cord-015021-pol2qm74 1377 7 of of IN cord-015021-pol2qm74 1377 8 adhesive adhesive JJ cord-015021-pol2qm74 1377 9 mechanisms mechanism NNS cord-015021-pol2qm74 1377 10 in in IN cord-015021-pol2qm74 1377 11 host host NN cord-015021-pol2qm74 1377 12 resistance resistance NN cord-015021-pol2qm74 1377 13 to to IN cord-015021-pol2qm74 1377 14 infection infection NN cord-015021-pol2qm74 1377 15 . . . cord-015021-pol2qm74 1378 1 As as IN cord-015021-pol2qm74 1378 2 human human JJ cord-015021-pol2qm74 1378 3 therapeutictdals therapeutictdal NNS cord-015021-pol2qm74 1378 4 are be VBP cord-015021-pol2qm74 1378 5 initiated initiate VBN cord-015021-pol2qm74 1378 6 , , , cord-015021-pol2qm74 1378 7 more more RBR cord-015021-pol2qm74 1378 8 exact exact JJ cord-015021-pol2qm74 1378 9 information information NN cord-015021-pol2qm74 1378 10 on on IN cord-015021-pol2qm74 1378 11 the the DT cord-015021-pol2qm74 1378 12 roles role NNS cord-015021-pol2qm74 1378 13 qf qf NN cord-015021-pol2qm74 1378 14 specific specific JJ cord-015021-pol2qm74 1378 15 adhesion adhesion NN cord-015021-pol2qm74 1378 16 molecules molecule NNS cord-015021-pol2qm74 1378 17 in in IN cord-015021-pol2qm74 1378 18 human human JJ cord-015021-pol2qm74 1378 19 disease disease NN cord-015021-pol2qm74 1378 20 should should MD cord-015021-pol2qm74 1378 21 emerge emerge VB cord-015021-pol2qm74 1378 22 . . . cord-015021-pol2qm74 1379 1 Inhibition inhibition NN cord-015021-pol2qm74 1379 2 of of IN cord-015021-pol2qm74 1379 3 leukocyte leukocyte NN cord-015021-pol2qm74 1379 4 adherence adherence NN cord-015021-pol2qm74 1379 5 to to IN cord-015021-pol2qm74 1379 6 endothelial endothelial JJ cord-015021-pol2qm74 1379 7 cells cell NNS cord-015021-pol2qm74 1379 8 can can MD cord-015021-pol2qm74 1379 9 represent represent VB cord-015021-pol2qm74 1379 10 a a DT cord-015021-pol2qm74 1379 11 novel novel JJ cord-015021-pol2qm74 1379 12 therapeutic therapeutic JJ cord-015021-pol2qm74 1379 13 approach approach NN cord-015021-pol2qm74 1379 14 to to IN cord-015021-pol2qm74 1379 15 septic septic JJ cord-015021-pol2qm74 1379 16 shock shock NN cord-015021-pol2qm74 1379 17 . . . cord-015021-pol2qm74 1380 1 We -PRON- PRP cord-015021-pol2qm74 1380 2 performed perform VBD cord-015021-pol2qm74 1380 3 a a DT cord-015021-pol2qm74 1380 4 pilot pilot NN cord-015021-pol2qm74 1380 5 study study NN cord-015021-pol2qm74 1380 6 to to TO cord-015021-pol2qm74 1380 7 evaluate evaluate VB cord-015021-pol2qm74 1380 8 the the DT cord-015021-pol2qm74 1380 9 safety safety NN cord-015021-pol2qm74 1380 10 and and CC cord-015021-pol2qm74 1380 11 tolerability tolerability NN cord-015021-pol2qm74 1380 12 to to IN cord-015021-pol2qm74 1380 13 CY-1787 CY-1787 NNP cord-015021-pol2qm74 1380 14 , , , cord-015021-pol2qm74 1380 15 a a DT cord-015021-pol2qm74 1380 16 monoclonal monoclonal JJ cord-015021-pol2qm74 1380 17 antibody antibody NN cord-015021-pol2qm74 1380 18 against against IN cord-015021-pol2qm74 1380 19 human human JJ cord-015021-pol2qm74 1380 20 E E NNP cord-015021-pol2qm74 1380 21 - - NN cord-015021-pol2qm74 1380 22 selectin selectin NNP cord-015021-pol2qm74 1380 23 , , , cord-015021-pol2qm74 1380 24 in in IN cord-015021-pol2qm74 1380 25 patients patient NNS cord-015021-pol2qm74 1380 26 with with IN cord-015021-pol2qm74 1380 27 septic septic JJ cord-015021-pol2qm74 1380 28 shock shock NN cord-015021-pol2qm74 1380 29 . . . cord-015021-pol2qm74 1381 1 Septic septic JJ cord-015021-pol2qm74 1381 2 shock shock NN cord-015021-pol2qm74 1381 3 was be VBD cord-015021-pol2qm74 1381 4 defined define VBN cord-015021-pol2qm74 1381 5 by by IN cord-015021-pol2qm74 1381 6 clinical clinical JJ cord-015021-pol2qm74 1381 7 signs sign NNS cord-015021-pol2qm74 1381 8 of of IN cord-015021-pol2qm74 1381 9 sepsis sepsis NN cord-015021-pol2qm74 1381 10 , , , cord-015021-pol2qm74 1381 11 a a DT cord-015021-pol2qm74 1381 12 documented document VBN cord-015021-pol2qm74 1381 13 source source NN cord-015021-pol2qm74 1381 14 of of IN cord-015021-pol2qm74 1381 15 infection infection NN cord-015021-pol2qm74 1381 16 , , , cord-015021-pol2qm74 1381 17 and and CC cord-015021-pol2qm74 1381 18 fluid fluid JJ cord-015021-pol2qm74 1381 19 - - HYPH cord-015021-pol2qm74 1381 20 resistant resistant JJ cord-015021-pol2qm74 1381 21 hypotension hypotension NN cord-015021-pol2qm74 1381 22 requiring require VBG cord-015021-pol2qm74 1381 23 the the DT cord-015021-pol2qm74 1381 24 use use NN cord-015021-pol2qm74 1381 25 of of IN cord-015021-pol2qm74 1381 26 vasopressors vasopressor NNS cord-015021-pol2qm74 1381 27 . . . cord-015021-pol2qm74 1382 1 Eleven eleven CD cord-015021-pol2qm74 1382 2 patients patient NNS cord-015021-pol2qm74 1382 3 entered enter VBD cord-015021-pol2qm74 1382 4 the the DT cord-015021-pol2qm74 1382 5 study study NN cord-015021-pol2qm74 1382 6 , , , cord-015021-pol2qm74 1382 7 but but CC cord-015021-pol2qm74 1382 8 2 2 CD cord-015021-pol2qm74 1382 9 patients patient NNS cord-015021-pol2qm74 1382 10 who who WP cord-015021-pol2qm74 1382 11 died die VBD cord-015021-pol2qm74 1382 12 during during IN cord-015021-pol2qm74 1382 13 the the DT cord-015021-pol2qm74 1382 14 first first JJ cord-015021-pol2qm74 1382 15 24 24 CD cord-015021-pol2qm74 1382 16 hours hour NNS cord-015021-pol2qm74 1382 17 were be VBD cord-015021-pol2qm74 1382 18 excluded exclude VBN cord-015021-pol2qm74 1382 19 , , , cord-015021-pol2qm74 1382 20 as as IN cord-015021-pol2qm74 1382 21 this this DT cord-015021-pol2qm74 1382 22 was be VBD cord-015021-pol2qm74 1382 23 part part NN cord-015021-pol2qm74 1382 24 of of IN cord-015021-pol2qm74 1382 25 the the DT cord-015021-pol2qm74 1382 26 protocol protocol NN cord-015021-pol2qm74 1382 27 . . . cord-015021-pol2qm74 1383 1 CY-1787 CY-1787 NNP cord-015021-pol2qm74 1383 2 was be VBD cord-015021-pol2qm74 1383 3 administered administer VBN cord-015021-pol2qm74 1383 4 as as IN cord-015021-pol2qm74 1383 5 a a DT cord-015021-pol2qm74 1383 6 single single JJ cord-015021-pol2qm74 1383 7 intravenous intravenous JJ cord-015021-pol2qm74 1383 8 bolus bolus NN cord-015021-pol2qm74 1383 9 of of IN cord-015021-pol2qm74 1383 10 0.1 0.1 CD cord-015021-pol2qm74 1383 11 mg mg NNP cord-015021-pol2qm74 1383 12 / / SYM cord-015021-pol2qm74 1383 13 kg kg NNP cord-015021-pol2qm74 1383 14 ( ( -LRB- cord-015021-pol2qm74 1383 15 N=3 N=3 NNP cord-015021-pol2qm74 1383 16 ) ) -RRB- cord-015021-pol2qm74 1383 17 , , , cord-015021-pol2qm74 1383 18 0.33 0.33 CD cord-015021-pol2qm74 1383 19 mg mg NNP cord-015021-pol2qm74 1383 20 / / SYM cord-015021-pol2qm74 1383 21 kg kg NNP cord-015021-pol2qm74 1383 22 ( ( -LRB- cord-015021-pol2qm74 1383 23 N=3 N=3 NNP cord-015021-pol2qm74 1383 24 ) ) -RRB- cord-015021-pol2qm74 1383 25 or or CC cord-015021-pol2qm74 1384 1 i i PRP cord-015021-pol2qm74 1385 1 mg mg NNP cord-015021-pol2qm74 1385 2 / / SYM cord-015021-pol2qm74 1385 3 kg kg NNP cord-015021-pol2qm74 1386 1 ( ( -LRB- cord-015021-pol2qm74 1386 2 N=3 N=3 NNP cord-015021-pol2qm74 1386 3 ) ) -RRB- cord-015021-pol2qm74 1386 4 mg mg NNP cord-015021-pol2qm74 1386 5 / / SYM cord-015021-pol2qm74 1386 6 kg kg NNP cord-015021-pol2qm74 1386 7 . . . cord-015021-pol2qm74 1387 1 The the DT cord-015021-pol2qm74 1387 2 antibody antibody NN cord-015021-pol2qm74 1387 3 was be VBD cord-015021-pol2qm74 1387 4 well well RB cord-015021-pol2qm74 1387 5 tolerated tolerate VBN cord-015021-pol2qm74 1387 6 . . . cord-015021-pol2qm74 1388 1 None none NN cord-015021-pol2qm74 1388 2 of of IN cord-015021-pol2qm74 1388 3 the the DT cord-015021-pol2qm74 1388 4 9 9 CD cord-015021-pol2qm74 1388 5 patients patient NNS cord-015021-pol2qm74 1388 6 died die VBD cord-015021-pol2qm74 1388 7 during during IN cord-015021-pol2qm74 1388 8 the the DT cord-015021-pol2qm74 1388 9 28 28 CD cord-015021-pol2qm74 1388 10 day day NN cord-015021-pol2qm74 1388 11 follow follow NN cord-015021-pol2qm74 1388 12 - - HYPH cord-015021-pol2qm74 1388 13 up up NN cord-015021-pol2qm74 1388 14 period period NN cord-015021-pol2qm74 1388 15 . . . cord-015021-pol2qm74 1389 1 Organ organ NN cord-015021-pol2qm74 1389 2 failure failure NN cord-015021-pol2qm74 1389 3 was be VBD cord-015021-pol2qm74 1389 4 assessed assess VBN cord-015021-pol2qm74 1389 5 for for IN cord-015021-pol2qm74 1389 6 5 5 CD cord-015021-pol2qm74 1389 7 organs organ NNS cord-015021-pol2qm74 1389 8 ( ( -LRB- cord-015021-pol2qm74 1389 9 CNS CNS NNP cord-015021-pol2qm74 1389 10 , , , cord-015021-pol2qm74 1389 11 lungs lung NNS cord-015021-pol2qm74 1389 12 , , , cord-015021-pol2qm74 1389 13 liver liver NN cord-015021-pol2qm74 1389 14 , , , cord-015021-pol2qm74 1389 15 kidneys kidney NNS cord-015021-pol2qm74 1389 16 and and CC cord-015021-pol2qm74 1389 17 coagulation coagulation NN cord-015021-pol2qm74 1389 18 ) ) -RRB- cord-015021-pol2qm74 1389 19 . . . cord-015021-pol2qm74 1390 1 The the DT cord-015021-pol2qm74 1390 2 mean mean JJ cord-015021-pol2qm74 1390 3 number number NN cord-015021-pol2qm74 1390 4 of of IN cord-015021-pol2qm74 1390 5 organs organ NNS cord-015021-pol2qm74 1390 6 failing fail VBG cord-015021-pol2qm74 1390 7 , , , cord-015021-pol2qm74 1390 8 which which WDT cord-015021-pol2qm74 1390 9 was be VBD cord-015021-pol2qm74 1390 10 initially initially RB cord-015021-pol2qm74 1390 11 2.7 2.7 CD cord-015021-pol2qm74 1390 12 ± ± CD cord-015021-pol2qm74 1390 13 1.2 1.2 CD cord-015021-pol2qm74 1390 14 , , , cord-015021-pol2qm74 1390 15 decreased decrease VBD cord-015021-pol2qm74 1390 16 to to IN cord-015021-pol2qm74 1390 17 0.2 0.2 CD cord-015021-pol2qm74 1390 18 ± ± CD cord-015021-pol2qm74 1390 19 0.4 0.4 CD cord-015021-pol2qm74 1390 20 at at IN cord-015021-pol2qm74 1390 21 the the DT cord-015021-pol2qm74 1390 22 end end NN cord-015021-pol2qm74 1390 23 of of IN cord-015021-pol2qm74 1390 24 the the DT cord-015021-pol2qm74 1390 25 study study NN cord-015021-pol2qm74 1390 26 ( ( -LRB- cord-015021-pol2qm74 1390 27 p p NN cord-015021-pol2qm74 1390 28 < < XX cord-015021-pol2qm74 1390 29 O.O01 o.o01 NN cord-015021-pol2qm74 1390 30 ) ) -RRB- cord-015021-pol2qm74 1390 31 . . . cord-015021-pol2qm74 1391 1 These these DT cord-015021-pol2qm74 1391 2 results result NNS cord-015021-pol2qm74 1391 3 are be VBP cord-015021-pol2qm74 1391 4 therefore therefore RB cord-015021-pol2qm74 1391 5 encouraging encouraging JJ cord-015021-pol2qm74 1391 6 . . . cord-015021-pol2qm74 1392 1 Administration administration NN cord-015021-pol2qm74 1392 2 of of IN cord-015021-pol2qm74 1392 3 an an DT cord-015021-pol2qm74 1392 4 antibody antibody NN cord-015021-pol2qm74 1392 5 to to IN cord-015021-pol2qm74 1392 6 E E NNP cord-015021-pol2qm74 1392 7 - - NN cord-015021-pol2qm74 1392 8 selectin selectin NNS cord-015021-pol2qm74 1392 9 in in IN cord-015021-pol2qm74 1392 10 patients patient NNS cord-015021-pol2qm74 1392 11 with with IN cord-015021-pol2qm74 1392 12 septic septic JJ cord-015021-pol2qm74 1392 13 shock shock NN cord-015021-pol2qm74 1392 14 requires require VBZ cord-015021-pol2qm74 1392 15 further further JJ cord-015021-pol2qm74 1392 16 study study NN cord-015021-pol2qm74 1392 17 . . . cord-015021-pol2qm74 1393 1 The the DT cord-015021-pol2qm74 1393 2 importance importance NN cord-015021-pol2qm74 1393 3 of of IN cord-015021-pol2qm74 1393 4 cytotoxic cytotoxic JJ cord-015021-pol2qm74 1393 5 T t NN cord-015021-pol2qm74 1393 6 lymphocytes lymphocyte NNS cord-015021-pol2qm74 1393 7 ( ( -LRB- cord-015021-pol2qm74 1393 8 CTL CTL NNP cord-015021-pol2qm74 1393 9 ) ) -RRB- cord-015021-pol2qm74 1393 10 in in IN cord-015021-pol2qm74 1393 11 the the DT cord-015021-pol2qm74 1393 12 host host NN cord-015021-pol2qm74 1393 13 defense defense NN cord-015021-pol2qm74 1393 14 mechanism mechanism NN cord-015021-pol2qm74 1393 15 against against IN cord-015021-pol2qm74 1393 16 viral viral JJ cord-015021-pol2qm74 1393 17 as as RB cord-015021-pol2qm74 1393 18 well well RB cord-015021-pol2qm74 1393 19 as as IN cord-015021-pol2qm74 1393 20 parasitic parasitic JJ cord-015021-pol2qm74 1393 21 and and CC cord-015021-pol2qm74 1393 22 bacterial bacterial JJ cord-015021-pol2qm74 1393 23 diseases disease NNS cord-015021-pol2qm74 1393 24 is be VBZ cord-015021-pol2qm74 1393 25 becoming become VBG cord-015021-pol2qm74 1393 26 increasingly increasingly RB cord-015021-pol2qm74 1393 27 appreciated appreciate VBN cord-015021-pol2qm74 1393 28 . . . cord-015021-pol2qm74 1394 1 The the DT cord-015021-pol2qm74 1394 2 design design NN cord-015021-pol2qm74 1394 3 of of IN cord-015021-pol2qm74 1394 4 vaccines vaccine NNS cord-015021-pol2qm74 1394 5 to to TO cord-015021-pol2qm74 1394 6 generate generate VB cord-015021-pol2qm74 1394 7 cytotoxic cytotoxic JJ cord-015021-pol2qm74 1394 8 T t NN cord-015021-pol2qm74 1394 9 ceils ceil NNS cord-015021-pol2qm74 1394 10 from from IN cord-015021-pol2qm74 1394 11 nonviable nonviable JJ cord-015021-pol2qm74 1394 12 or or CC cord-015021-pol2qm74 1394 13 subunit subunit NN cord-015021-pol2qm74 1394 14 constructs construct NNS cord-015021-pol2qm74 1394 15 , , , cord-015021-pol2qm74 1394 16 however however RB cord-015021-pol2qm74 1394 17 , , , cord-015021-pol2qm74 1394 18 poses pose VBZ cord-015021-pol2qm74 1394 19 challenges challenge NNS cord-015021-pol2qm74 1394 20 due due JJ cord-015021-pol2qm74 1394 21 to to IN cord-015021-pol2qm74 1394 22 the the DT cord-015021-pol2qm74 1394 23 unique unique JJ cord-015021-pol2qm74 1394 24 characteristics characteristic NNS cord-015021-pol2qm74 1394 25 of of IN cord-015021-pol2qm74 1394 26 antigen antigen NN cord-015021-pol2qm74 1394 27 processing processing NN cord-015021-pol2qm74 1394 28 and and CC cord-015021-pol2qm74 1394 29 presentation presentation NN cord-015021-pol2qm74 1394 30 by by IN cord-015021-pol2qm74 1394 31 class class NN cord-015021-pol2qm74 1395 1 I -PRON- PRP cord-015021-pol2qm74 1395 2 major major JJ cord-015021-pol2qm74 1395 3 histocompatibility histocompatibility NN cord-015021-pol2qm74 1395 4 complex complex NN cord-015021-pol2qm74 1395 5 ( ( -LRB- cord-015021-pol2qm74 1395 6 MHC MHC NNP cord-015021-pol2qm74 1395 7 ) ) -RRB- cord-015021-pol2qm74 1395 8 molecules molecule NNS cord-015021-pol2qm74 1395 9 . . . cord-015021-pol2qm74 1396 1 Since since IN cord-015021-pol2qm74 1396 2 the the DT cord-015021-pol2qm74 1396 3 final final JJ cord-015021-pol2qm74 1396 4 antigen antigen NN cord-015021-pol2qm74 1396 5 recognized recognize VBN cord-015021-pol2qm74 1396 6 by by IN cord-015021-pol2qm74 1396 7 CTL CTL NNP cord-015021-pol2qm74 1396 8 are be VBP cord-015021-pol2qm74 1396 9 short short JJ cord-015021-pol2qm74 1396 10 peptides peptide NNS cord-015021-pol2qm74 1396 11 capable capable JJ cord-015021-pol2qm74 1396 12 of of IN cord-015021-pol2qm74 1396 13 high high JJ cord-015021-pol2qm74 1396 14 affinity affinity NN cord-015021-pol2qm74 1396 15 binding bind VBG cord-015021-pol2qm74 1396 16 to to IN cord-015021-pol2qm74 1396 17 class class NN cord-015021-pol2qm74 1396 18 I -PRON- PRP cord-015021-pol2qm74 1396 19 MHC MHC NNP cord-015021-pol2qm74 1396 20 molecules molecule NNS cord-015021-pol2qm74 1396 21 , , , cord-015021-pol2qm74 1396 22 we -PRON- PRP cord-015021-pol2qm74 1396 23 have have VBP cord-015021-pol2qm74 1396 24 designed design VBN cord-015021-pol2qm74 1396 25 strategies strategy NNS cord-015021-pol2qm74 1396 26 : : : cord-015021-pol2qm74 1396 27 a a LS cord-015021-pol2qm74 1396 28 ) ) -RRB- cord-015021-pol2qm74 1396 29 to to TO cord-015021-pol2qm74 1396 30 define define VB cord-015021-pol2qm74 1396 31 the the DT cord-015021-pol2qm74 1396 32 structural structural JJ cord-015021-pol2qm74 1396 33 characteristics characteristic NNS cord-015021-pol2qm74 1396 34 of of IN cord-015021-pol2qm74 1396 35 peptides peptide NNS cord-015021-pol2qm74 1396 36 that that WDT cord-015021-pol2qm74 1396 37 are be VBP cord-015021-pol2qm74 1396 38 required require VBN cord-015021-pol2qm74 1396 39 for for IN cord-015021-pol2qm74 1396 40 their -PRON- PRP$ cord-015021-pol2qm74 1396 41 high high JJ cord-015021-pol2qm74 1396 42 affinity affinity NN cord-015021-pol2qm74 1396 43 binding bind VBG cord-015021-pol2qm74 1396 44 to to IN cord-015021-pol2qm74 1396 45 MHC MHC NNP cord-015021-pol2qm74 1396 46 ; ; : cord-015021-pol2qm74 1396 47 and and CC cord-015021-pol2qm74 1396 48 b b LS cord-015021-pol2qm74 1396 49 ) ) -RRB- cord-015021-pol2qm74 1396 50 to to TO cord-015021-pol2qm74 1396 51 formulate formulate VB cord-015021-pol2qm74 1396 52 these these DT cord-015021-pol2qm74 1396 53 peptides peptide NNS cord-015021-pol2qm74 1396 54 into into IN cord-015021-pol2qm74 1396 55 immunogenic immunogenic JJ cord-015021-pol2qm74 1396 56 vaccines vaccine NNS cord-015021-pol2qm74 1396 57 that that WDT cord-015021-pol2qm74 1396 58 are be VBP cord-015021-pol2qm74 1396 59 capable capable JJ cord-015021-pol2qm74 1396 60 of of IN cord-015021-pol2qm74 1396 61 generating generate VBG cord-015021-pol2qm74 1396 62 cytotoxic cytotoxic JJ cord-015021-pol2qm74 1396 63 T t NN cord-015021-pol2qm74 1396 64 lymphocytes lymphocyte NNS cord-015021-pol2qm74 1396 65 . . . cord-015021-pol2qm74 1397 1 The the DT cord-015021-pol2qm74 1397 2 strategy strategy NN cord-015021-pol2qm74 1397 3 and and CC cord-015021-pol2qm74 1397 4 results result VBZ cord-015021-pol2qm74 1397 5 to to TO cord-015021-pol2qm74 1397 6 accomplish accomplish VB cord-015021-pol2qm74 1397 7 these these DT cord-015021-pol2qm74 1397 8 two two CD cord-015021-pol2qm74 1397 9 goals goal NNS cord-015021-pol2qm74 1397 10 will will MD cord-015021-pol2qm74 1397 11 be be VB cord-015021-pol2qm74 1397 12 discussed discuss VBN cord-015021-pol2qm74 1397 13 . . . cord-015021-pol2qm74 1398 1 Amnon Amnon NNP cord-015021-pol2qm74 1398 2 Altman Altman NNP cord-015021-pol2qm74 1398 3 and and CC cord-015021-pol2qm74 1398 4 Erich Erich NNP cord-015021-pol2qm74 1398 5 Gulbins Gulbins NNP cord-015021-pol2qm74 1398 6 Ras Ras NNP cord-015021-pol2qm74 1398 7 proteins protein NNS cord-015021-pol2qm74 1398 8 represent represent VBP cord-015021-pol2qm74 1398 9 essential essential JJ cord-015021-pol2qm74 1398 10 intermediates intermediate NNS cord-015021-pol2qm74 1398 11 in in IN cord-015021-pol2qm74 1398 12 receptor receptor NN cord-015021-pol2qm74 1398 13 - - HYPH cord-015021-pol2qm74 1398 14 mediated mediate VBN cord-015021-pol2qm74 1398 15 growth growth NN cord-015021-pol2qm74 1398 16 and and CC cord-015021-pol2qm74 1398 17 differentiation differentiation NN cord-015021-pol2qm74 1398 18 pathways pathway NNS cord-015021-pol2qm74 1398 19 . . . cord-015021-pol2qm74 1399 1 They -PRON- PRP cord-015021-pol2qm74 1399 2 couple couple NN cord-015021-pol2qm74 1399 3 signals signal NNS cord-015021-pol2qm74 1399 4 initiated initiate VBN cord-015021-pol2qm74 1399 5 by by IN cord-015021-pol2qm74 1399 6 receptor receptor NN cord-015021-pol2qm74 1399 7 or or CC cord-015021-pol2qm74 1399 8 nonreceptor nonreceptor NN cord-015021-pol2qm74 1399 9 protein protein NN cord-015021-pol2qm74 1399 10 tyrosine tyrosine NN cord-015021-pol2qm74 1399 11 kinases kinase NNS cord-015021-pol2qm74 1399 12 ( ( -LRB- cord-015021-pol2qm74 1399 13 PTKs PTKs NNP cord-015021-pol2qm74 1399 14 ) ) -RRB- cord-015021-pol2qm74 1399 15 at at IN cord-015021-pol2qm74 1399 16 the the DT cord-015021-pol2qm74 1399 17 cell cell NN cord-015021-pol2qm74 1399 18 surface surface NN cord-015021-pol2qm74 1399 19 to to IN cord-015021-pol2qm74 1399 20 cytoplasmic cytoplasmic JJ cord-015021-pol2qm74 1399 21 targets target NNS cord-015021-pol2qm74 1399 22 which which WDT cord-015021-pol2qm74 1399 23 coordinate coordinate VBP cord-015021-pol2qm74 1399 24 signal signal NN cord-015021-pol2qm74 1399 25 transduciion transduciion NN cord-015021-pol2qm74 1399 26 to to IN cord-015021-pol2qm74 1399 27 the the DT cord-015021-pol2qm74 1399 28 nucleus nucleus NN cord-015021-pol2qm74 1399 29 . . . cord-015021-pol2qm74 1400 1 Ras Ras NNP cord-015021-pol2qm74 1400 2 also also RB cord-015021-pol2qm74 1400 3 participates participate VBZ cord-015021-pol2qm74 1400 4 in in IN cord-015021-pol2qm74 1400 5 T T NNP cord-015021-pol2qm74 1400 6 lymphocyte lymphocyte NN cord-015021-pol2qm74 1400 7 activation activation NN cord-015021-pol2qm74 1400 8 initiated initiate VBN cord-015021-pol2qm74 1400 9 by by IN cord-015021-pol2qm74 1400 10 the the DT cord-015021-pol2qm74 1400 11 antigen antigen NN cord-015021-pol2qm74 1400 12 - - HYPH cord-015021-pol2qm74 1400 13 specific specific JJ cord-015021-pol2qm74 1400 14 T t NN cord-015021-pol2qm74 1400 15 cell cell NN cord-015021-pol2qm74 1400 16 receptor receptor NN cord-015021-pol2qm74 1400 17 ( ( -LRB- cord-015021-pol2qm74 1400 18 TCR)/CD3 TCR)/CD3 NNP cord-015021-pol2qm74 1400 19 complex complex NN cord-015021-pol2qm74 1400 20 , , , cord-015021-pol2qm74 1400 21 which which WDT cord-015021-pol2qm74 1400 22 leads lead VBZ cord-015021-pol2qm74 1400 23 to to IN cord-015021-pol2qm74 1400 24 lymphokine lymphokine NN cord-015021-pol2qm74 1400 25 production production NN cord-015021-pol2qm74 1400 26 and and CC cord-015021-pol2qm74 1400 27 proliferation proliferation NN cord-015021-pol2qm74 1400 28 . . . cord-015021-pol2qm74 1401 1 Receptor receptor NN cord-015021-pol2qm74 1401 2 ligation ligation NN cord-015021-pol2qm74 1401 3 causes cause VBZ cord-015021-pol2qm74 1401 4 activation activation NN cord-015021-pol2qm74 1401 5 of of IN cord-015021-pol2qm74 1401 6 associated associate VBN cord-015021-pol2qm74 1401 7 PTKs PTKs NNP cord-015021-pol2qm74 1401 8 of of IN cord-015021-pol2qm74 1401 9 the the DT cord-015021-pol2qm74 1401 10 Src Src NNP cord-015021-pol2qm74 1401 11 and and CC cord-015021-pol2qm74 1401 12 Syk Syk NNP cord-015021-pol2qm74 1401 13 families family NNS cord-015021-pol2qm74 1401 14 as as IN cord-015021-pol2qm74 1401 15 the the DT cord-015021-pol2qm74 1401 16 earliest early JJS cord-015021-pol2qm74 1401 17 identifiable identifiable JJ cord-015021-pol2qm74 1401 18 event event NN cord-015021-pol2qm74 1401 19 in in IN cord-015021-pol2qm74 1401 20 this this DT cord-015021-pol2qm74 1401 21 pathway pathway NN cord-015021-pol2qm74 1401 22 . . . cord-015021-pol2qm74 1402 1 The the DT cord-015021-pol2qm74 1402 2 importance importance NN cord-015021-pol2qm74 1402 3 of of IN cord-015021-pol2qm74 1402 4 Ras Ras NNP cord-015021-pol2qm74 1402 5 in in IN cord-015021-pol2qm74 1402 6 T T NNP cord-015021-pol2qm74 1402 7 cell cell NN cord-015021-pol2qm74 1402 8 activation activation NN cord-015021-pol2qm74 1402 9 is be VBZ cord-015021-pol2qm74 1402 10 indicated indicate VBN cord-015021-pol2qm74 1402 11 by by IN cord-015021-pol2qm74 1402 12 the the DT cord-015021-pol2qm74 1402 13 findings finding NNS cord-015021-pol2qm74 1402 14 that that IN cord-015021-pol2qm74 1402 15 an an DT cord-015021-pol2qm74 1402 16 oncogenic oncogenic JJ cord-015021-pol2qm74 1402 17 Ras Ras NNP cord-015021-pol2qm74 1402 18 protein protein NN cord-015021-pol2qm74 1402 19 activates activate VBZ cord-015021-pol2qm74 1402 20 the the DT cord-015021-pol2qm74 1402 21 interleukin-2 interleukin-2 NN cord-015021-pol2qm74 1402 22 ( ( -LRB- cord-015021-pol2qm74 1402 23 IL-2 IL-2 NNP cord-015021-pol2qm74 1402 24 ) ) -RRB- cord-015021-pol2qm74 1402 25 gene gene NN cord-015021-pol2qm74 1402 26 promoter promoter NN cord-015021-pol2qm74 1402 27 ; ; : cord-015021-pol2qm74 1402 28 conversely conversely RB cord-015021-pol2qm74 1402 29 , , , cord-015021-pol2qm74 1402 30 a a DT cord-015021-pol2qm74 1402 31 transdominant transdominant JJ cord-015021-pol2qm74 1402 32 inhibitory inhibitory JJ cord-015021-pol2qm74 1402 33 ras ras NNP cord-015021-pol2qm74 1402 34 mutant mutant NN cord-015021-pol2qm74 1402 35 inhibits inhibit VBZ cord-015021-pol2qm74 1402 36 this this DT cord-015021-pol2qm74 1402 37 event event NN cord-015021-pol2qm74 1402 38 and and CC cord-015021-pol2qm74 1402 39 the the DT cord-015021-pol2qm74 1402 40 activation activation NN cord-015021-pol2qm74 1402 41 of of IN cord-015021-pol2qm74 1402 42 MAP MAP NNP cord-015021-pol2qm74 1402 43 kinases kinase NNS cord-015021-pol2qm74 1402 44 . . . cord-015021-pol2qm74 1403 1 The the DT cord-015021-pol2qm74 1403 2 rate rate NN cord-015021-pol2qm74 1403 3 - - HYPH cord-015021-pol2qm74 1403 4 limiting limit VBG cord-015021-pol2qm74 1403 5 step step NN cord-015021-pol2qm74 1403 6 in in IN cord-015021-pol2qm74 1403 7 Ras Ras NNP cord-015021-pol2qm74 1403 8 activation activation NN cord-015021-pol2qm74 1403 9 is be VBZ cord-015021-pol2qm74 1403 10 the the DT cord-015021-pol2qm74 1403 11 exchange exchange NN cord-015021-pol2qm74 1403 12 of of IN cord-015021-pol2qm74 1403 13 bound bind VBN cord-015021-pol2qm74 1403 14 GDP GDP NNP cord-015021-pol2qm74 1403 15 for for IN cord-015021-pol2qm74 1403 16 GTP GTP NNP cord-015021-pol2qm74 1403 17 , , , cord-015021-pol2qm74 1403 18 which which WDT cord-015021-pol2qm74 1403 19 is be VBZ cord-015021-pol2qm74 1403 20 catalysed catalyse VBN cord-015021-pol2qm74 1403 21 by by IN cord-015021-pol2qm74 1403 22 guanine guanine NN cord-015021-pol2qm74 1403 23 nucleotide nucleotide JJ cord-015021-pol2qm74 1403 24 exchange exchange NN cord-015021-pol2qm74 1403 25 factors factor NNS cord-015021-pol2qm74 1403 26 ( ( -LRB- cord-015021-pol2qm74 1403 27 GEFs GEFs NNP cord-015021-pol2qm74 1403 28 ) ) -RRB- cord-015021-pol2qm74 1403 29 . . . cord-015021-pol2qm74 1404 1 We -PRON- PRP cord-015021-pol2qm74 1404 2 identified identify VBD cord-015021-pol2qm74 1404 3 the the DT cord-015021-pol2qm74 1404 4 SH2 SH2 NNP cord-015021-pol2qm74 1404 5 / / SYM cord-015021-pol2qm74 1404 6 SH3 SH3 NNP cord-015021-pol2qm74 1404 7 domain domain NN cord-015021-pol2qm74 1404 8 - - HYPH cord-015021-pol2qm74 1404 9 containing contain VBG cord-015021-pol2qm74 1404 10 Vav Vav NNP cord-015021-pol2qm74 1404 11 protein protein NN cord-015021-pol2qm74 1404 12 , , , cord-015021-pol2qm74 1404 13 which which WDT cord-015021-pol2qm74 1404 14 is be VBZ cord-015021-pol2qm74 1404 15 selectively selectively RB cord-015021-pol2qm74 1404 16 expressed express VBN cord-015021-pol2qm74 1404 17 in in IN cord-015021-pol2qm74 1404 18 hematopoietic hematopoietic JJ cord-015021-pol2qm74 1404 19 cells cell NNS cord-015021-pol2qm74 1404 20 , , , cord-015021-pol2qm74 1404 21 as as IN cord-015021-pol2qm74 1404 22 a a DT cord-015021-pol2qm74 1404 23 Ras Ras NNP cord-015021-pol2qm74 1404 24 - - HYPH cord-015021-pol2qm74 1404 25 specific specific JJ cord-015021-pol2qm74 1404 26 GEF GEF NNP cord-015021-pol2qm74 1404 27 coupled couple VBN cord-015021-pol2qm74 1404 28 to to IN cord-015021-pol2qm74 1404 29 several several JJ cord-015021-pol2qm74 1404 30 hematopoietic hematopoietic JJ cord-015021-pol2qm74 1404 31 receptors receptor NNS cord-015021-pol2qm74 1404 32 . . . cord-015021-pol2qm74 1405 1 Vav Vav NNP cord-015021-pol2qm74 1405 2 can can MD cord-015021-pol2qm74 1405 3 be be VB cord-015021-pol2qm74 1405 4 activated activate VBN cord-015021-pol2qm74 1405 5 by by IN cord-015021-pol2qm74 1405 6 two two CD cord-015021-pol2qm74 1405 7 pathways pathway NNS cord-015021-pol2qm74 1405 8 , , , cord-015021-pol2qm74 1405 9 i.e. i.e. FW cord-015021-pol2qm74 1405 10 , , , cord-015021-pol2qm74 1405 11 by by IN cord-015021-pol2qm74 1405 12 PTK PTK NNP cord-015021-pol2qm74 1405 13 - - HYPH cord-015021-pol2qm74 1405 14 mediated mediate VBN cord-015021-pol2qm74 1405 15 phosphorylation phosphorylation NN cord-015021-pol2qm74 1405 16 or or CC cord-015021-pol2qm74 1405 17 by by IN cord-015021-pol2qm74 1405 18 binding bind VBG cord-015021-pol2qm74 1405 19 of of IN cord-015021-pol2qm74 1405 20 diglyceride diglyceride NN cord-015021-pol2qm74 1405 21 second second JJ cord-015021-pol2qm74 1405 22 messengers messenger NNS cord-015021-pol2qm74 1405 23 to to IN cord-015021-pol2qm74 1405 24 a a DT cord-015021-pol2qm74 1405 25 cysteine cysteine NN cord-015021-pol2qm74 1405 26 - - HYPH cord-015021-pol2qm74 1405 27 rich rich JJ cord-015021-pol2qm74 1405 28 , , , cord-015021-pol2qm74 1405 29 protein protein NN cord-015021-pol2qm74 1405 30 kinase kinase NN cord-015021-pol2qm74 1405 31 C c NN cord-015021-pol2qm74 1405 32 ( ( -LRB- cord-015021-pol2qm74 1405 33 PKC)homologous PKC)homologous NNP cord-015021-pol2qm74 1405 34 Vav Vav NNP cord-015021-pol2qm74 1405 35 domain domain NN cord-015021-pol2qm74 1405 36 . . . cord-015021-pol2qm74 1406 1 These these DT cord-015021-pol2qm74 1406 2 pathways pathway NNS cord-015021-pol2qm74 1406 3 are be VBP cord-015021-pol2qm74 1406 4 independent independent JJ cord-015021-pol2qm74 1406 5 as as IN cord-015021-pol2qm74 1406 6 demonstrated demonstrate VBN cord-015021-pol2qm74 1406 7 by by IN cord-015021-pol2qm74 1406 8 structure structure NN cord-015021-pol2qm74 1406 9 / / SYM cord-015021-pol2qm74 1406 10 function function NN cord-015021-pol2qm74 1406 11 analysis analysis NN cord-015021-pol2qm74 1406 12 and and CC cord-015021-pol2qm74 1406 13 the the DT cord-015021-pol2qm74 1406 14 use use NN cord-015021-pol2qm74 1406 15 of of IN cord-015021-pol2qm74 1406 16 pharmacological pharmacological JJ cord-015021-pol2qm74 1406 17 inhibitors inhibitor NNS cord-015021-pol2qm74 1406 18 . . . cord-015021-pol2qm74 1407 1 The the DT cord-015021-pol2qm74 1407 2 two two CD cord-015021-pol2qm74 1407 3 activation activation NN cord-015021-pol2qm74 1407 4 pathways pathway NNS cord-015021-pol2qm74 1407 5 may may MD cord-015021-pol2qm74 1407 6 enable enable VB cord-015021-pol2qm74 1407 7 Vav Vav NNP cord-015021-pol2qm74 1407 8 to to TO cord-015021-pol2qm74 1407 9 integrate integrate VB cord-015021-pol2qm74 1407 10 signals signal NNS cord-015021-pol2qm74 1407 11 from from IN cord-015021-pol2qm74 1407 12 distinct distinct JJ cord-015021-pol2qm74 1407 13 hematopoietic hematopoietic JJ cord-015021-pol2qm74 1407 14 cell cell NN cord-015021-pol2qm74 1407 15 receptors receptor NNS cord-015021-pol2qm74 1407 16 , , , cord-015021-pol2qm74 1407 17 and and CC cord-015021-pol2qm74 1407 18 couple couple VB cord-015021-pol2qm74 1407 19 them -PRON- PRP cord-015021-pol2qm74 1407 20 to to IN cord-015021-pol2qm74 1407 21 Ras Ras NNP cord-015021-pol2qm74 1407 22 . . . cord-015021-pol2qm74 1408 1 T T NNP cord-015021-pol2qm74 1408 2 cells cell NNS cord-015021-pol2qm74 1408 3 express express VBP cord-015021-pol2qm74 1408 4 another another DT cord-015021-pol2qm74 1408 5 , , , cord-015021-pol2qm74 1408 6 ubiquitous ubiquitous JJ cord-015021-pol2qm74 1408 7 Ras Ras NNP cord-015021-pol2qm74 1408 8 GEF GEF NNP cord-015021-pol2qm74 1408 9 , , , cord-015021-pol2qm74 1408 10 i.e. i.e. FW cord-015021-pol2qm74 1408 11 , , , cord-015021-pol2qm74 1408 12 Sos Sos NNP cord-015021-pol2qm74 1408 13 , , , cord-015021-pol2qm74 1408 14 which which WDT cord-015021-pol2qm74 1408 15 is be VBZ cord-015021-pol2qm74 1408 16 known know VBN cord-015021-pol2qm74 1408 17 to to TO cord-015021-pol2qm74 1408 18 be be VB cord-015021-pol2qm74 1408 19 coupled couple VBN cord-015021-pol2qm74 1408 20 to to IN cord-015021-pol2qm74 1408 21 activated activate VBN cord-015021-pol2qm74 1408 22 TPK TPK NNP cord-015021-pol2qm74 1408 23 receptors receptor NNS cord-015021-pol2qm74 1408 24 . . . cord-015021-pol2qm74 1409 1 T T NNP cord-015021-pol2qm74 1409 2 cell cell NN cord-015021-pol2qm74 1409 3 activation activation NN cord-015021-pol2qm74 1409 4 leads lead VBZ cord-015021-pol2qm74 1409 5 to to IN cord-015021-pol2qm74 1409 6 membrane membrane NNP cord-015021-pol2qm74 1409 7 association association NNP cord-015021-pol2qm74 1409 8 of of IN cord-015021-pol2qm74 1409 9 a a DT cord-015021-pol2qm74 1409 10 signaling signal VBG cord-015021-pol2qm74 1409 11 complex complex NN cord-015021-pol2qm74 1409 12 consisting consisting NN cord-015021-pol2qm74 1409 13 of of IN cord-015021-pol2qm74 1409 14 Sos Sos NNP cord-015021-pol2qm74 1409 15 and and CC cord-015021-pol2qm74 1409 16 two two CD cord-015021-pol2qm74 1409 17 other other JJ cord-015021-pol2qm74 1409 18 signaling signal VBG cord-015021-pol2qm74 1409 19 proteins protein NNS cord-015021-pol2qm74 1409 20 , , , cord-015021-pol2qm74 1409 21 Grb-2 Grb-2 NNP cord-015021-pol2qm74 1409 22 and and CC cord-015021-pol2qm74 1409 23 Shc Shc NNP cord-015021-pol2qm74 1409 24 , , , cord-015021-pol2qm74 1409 25 via via IN cord-015021-pol2qm74 1409 26 direct direct JJ cord-015021-pol2qm74 1409 27 binding binding NN cord-015021-pol2qm74 1409 28 of of IN cord-015021-pol2qm74 1409 29 the the DT cord-015021-pol2qm74 1409 30 Shc Shc NNP cord-015021-pol2qm74 1409 31 SH2 SH2 NNP cord-015021-pol2qm74 1409 32 domain domain NN cord-015021-pol2qm74 1409 33 to to IN cord-015021-pol2qm74 1409 34 the the DT cord-015021-pol2qm74 1409 35 tyrosine tyrosine NN cord-015021-pol2qm74 1409 36 - - HYPH cord-015021-pol2qm74 1409 37 phosphorylated phosphorylate VBN cord-015021-pol2qm74 1409 38 chain chain NN cord-015021-pol2qm74 1409 39 of of IN cord-015021-pol2qm74 1409 40 the the DT cord-015021-pol2qm74 1409 41 TCR TCR NNP cord-015021-pol2qm74 1409 42 / / SYM cord-015021-pol2qm74 1409 43 CD3 CD3 NNP cord-015021-pol2qm74 1409 44 complex complex NN cord-015021-pol2qm74 1409 45 . . . cord-015021-pol2qm74 1410 1 Thus thus RB cord-015021-pol2qm74 1410 2 , , , cord-015021-pol2qm74 1410 3 multiple multiple JJ cord-015021-pol2qm74 1410 4 receptors receptor NNS cord-015021-pol2qm74 1410 5 , , , cord-015021-pol2qm74 1410 6 PTKs PTKs NNP cord-015021-pol2qm74 1410 7 and and CC cord-015021-pol2qm74 1410 8 Ras Ras NNP cord-015021-pol2qm74 1410 9 activators activator NNS cord-015021-pol2qm74 1410 10 participate participate VBP cord-015021-pol2qm74 1410 11 in in IN cord-015021-pol2qm74 1410 12 signaling signal VBG cord-015021-pol2qm74 1410 13 pathways pathway NNS cord-015021-pol2qm74 1410 14 that that WDT cord-015021-pol2qm74 1410 15 lead lead VBP cord-015021-pol2qm74 1410 16 to to IN cord-015021-pol2qm74 1410 17 hematopoieitc hematopoieitc NN cord-015021-pol2qm74 1410 18 cell cell NN cord-015021-pol2qm74 1410 19 growth growth NN cord-015021-pol2qm74 1410 20 and and CC cord-015021-pol2qm74 1410 21 differentiation differentiation NN cord-015021-pol2qm74 1410 22 . . . cord-015021-pol2qm74 1411 1 The the DT cord-015021-pol2qm74 1411 2 interactions interaction NNS cord-015021-pol2qm74 1411 3 and and CC cord-015021-pol2qm74 1411 4 function function NN cord-015021-pol2qm74 1411 5 of of IN cord-015021-pol2qm74 1411 6 these these DT cord-015021-pol2qm74 1411 7 various various JJ cord-015021-pol2qm74 1411 8 signal signal NN cord-015021-pol2qm74 1411 9 transducers transducer NNS cord-015021-pol2qm74 1411 10 will will MD cord-015021-pol2qm74 1411 11 be be VB cord-015021-pol2qm74 1411 12 reviewed review VBN cord-015021-pol2qm74 1411 13 . . . cord-015021-pol2qm74 1412 1 phagocytes phagocyte NNS cord-015021-pol2qm74 1412 2 . . . cord-015021-pol2qm74 1413 1 Immunity immunity NN cord-015021-pol2qm74 1413 2 is be VBZ cord-015021-pol2qm74 1413 3 mediated mediate VBN cord-015021-pol2qm74 1413 4 by by IN cord-015021-pol2qm74 1413 5 specific specific JJ cord-015021-pol2qm74 1413 6 T t NN cord-015021-pol2qm74 1413 7 lymphocytes lymphocyte NNS cord-015021-pol2qm74 1413 8 , , , cord-015021-pol2qm74 1413 9 Cytokines Cytokines NNP cord-015021-pol2qm74 1413 10 produced produce VBN cord-015021-pol2qm74 1413 11 by by IN cord-015021-pol2qm74 1413 12 these these DT cord-015021-pol2qm74 1413 13 specific specific JJ cord-015021-pol2qm74 1413 14 T t NN cord-015021-pol2qm74 1413 15 cells cell NNS cord-015021-pol2qm74 1413 16 activate activate VBP cord-015021-pol2qm74 1413 17 antimicrobial antimicrobial JJ cord-015021-pol2qm74 1413 18 capacities capacity NNS cord-015021-pol2qm74 1413 19 in in IN cord-015021-pol2qm74 1413 20 mononuclear mononuclear JJ cord-015021-pol2qm74 1413 21 phagocytes phagocyte NNS cord-015021-pol2qm74 1413 22 , , , cord-015021-pol2qm74 1413 23 thus thus RB cord-015021-pol2qm74 1413 24 contributing contribute VBG cord-015021-pol2qm74 1413 25 to to IN cord-015021-pol2qm74 1413 26 protection protection NN cord-015021-pol2qm74 1413 27 . . . cord-015021-pol2qm74 1414 1 Other other JJ cord-015021-pol2qm74 1414 2 immune immune JJ cord-015021-pol2qm74 1414 3 mechanisms mechanism NNS cord-015021-pol2qm74 1414 4 also also RB cord-015021-pol2qm74 1414 5 participate participate VBP cord-015021-pol2qm74 1414 6 in in IN cord-015021-pol2qm74 1414 7 the the DT cord-015021-pol2qm74 1414 8 acquisition acquisition NN cord-015021-pol2qm74 1414 9 of of IN cord-015021-pol2qm74 1414 10 resistance resistance NN cord-015021-pol2qm74 1414 11 . . . cord-015021-pol2qm74 1415 1 On on IN cord-015021-pol2qm74 1415 2 the the DT cord-015021-pol2qm74 1415 3 other other JJ cord-015021-pol2qm74 1415 4 hand hand NN cord-015021-pol2qm74 1415 5 , , , cord-015021-pol2qm74 1415 6 T t NN cord-015021-pol2qm74 1415 7 cells cell NNS cord-015021-pol2qm74 1415 8 are be VBP cord-015021-pol2qm74 1415 9 also also RB cord-015021-pol2qm74 1415 10 crucial crucial JJ cord-015021-pol2qm74 1415 11 for for IN cord-015021-pol2qm74 1415 12 many many JJ cord-015021-pol2qm74 1415 13 pathologic pathologic JJ cord-015021-pol2qm74 1415 14 sequelae sequela NNS cord-015021-pol2qm74 1415 15 of of IN cord-015021-pol2qm74 1415 16 intracellular intracellular JJ cord-015021-pol2qm74 1415 17 bacterial bacterial JJ cord-015021-pol2qm74 1415 18 infections infection NNS cord-015021-pol2qm74 1415 19 . . . cord-015021-pol2qm74 1416 1 Although although IN cord-015021-pol2qm74 1416 2 IFN IFN NNP cord-015021-pol2qm74 1416 3 - - HYPH cord-015021-pol2qm74 1416 4 y y NNP cord-015021-pol2qm74 1416 5 is be VBZ cord-015021-pol2qm74 1416 6 central central JJ cord-015021-pol2qm74 1416 7 to to IN cord-015021-pol2qm74 1416 8 macrophage macrophage NN cord-015021-pol2qm74 1416 9 activation activation NN cord-015021-pol2qm74 1416 10 , , , cord-015021-pol2qm74 1416 11 synergistic synergistic JJ cord-015021-pol2qm74 1416 12 and and CC cord-015021-pol2qm74 1416 13 antagonistic antagonistic JJ cord-015021-pol2qm74 1416 14 effects effect NNS cord-015021-pol2qm74 1416 15 with with IN cord-015021-pol2qm74 1416 16 other other JJ cord-015021-pol2qm74 1416 17 cytokines cytokine NNS cord-015021-pol2qm74 1416 18 occur occur VBP cord-015021-pol2qm74 1416 19 . . . cord-015021-pol2qm74 1417 1 The the DT cord-015021-pol2qm74 1417 2 cd/3 cd/3 NN cord-015021-pol2qm74 1417 3 T t NN cord-015021-pol2qm74 1417 4 cells cell NNS cord-015021-pol2qm74 1417 5 , , , cord-015021-pol2qm74 1417 6 representing represent VBG cord-015021-pol2qm74 1417 7 the the DT cord-015021-pol2qm74 1417 8 major major JJ cord-015021-pol2qm74 1417 9 T T NNP cord-015021-pol2qm74 1417 10 cell cell NN cord-015021-pol2qm74 1417 11 population population NN cord-015021-pol2qm74 1417 12 in in IN cord-015021-pol2qm74 1417 13 experimental experimental JJ cord-015021-pol2qm74 1417 14 mice mouse NNS cord-015021-pol2qm74 1417 15 , , , cord-015021-pol2qm74 1417 16 are be VBP cord-015021-pol2qm74 1417 17 the the DT cord-015021-pol2qm74 1417 18 main main JJ cord-015021-pol2qm74 1417 19 mediators mediator NNS cord-015021-pol2qm74 1417 20 of of IN cord-015021-pol2qm74 1417 21 antibacterial antibacterial JJ cord-015021-pol2qm74 1417 22 immunity immunity NN cord-015021-pol2qm74 1417 23 ; ; : cord-015021-pol2qm74 1417 24 an an DT cord-015021-pol2qm74 1417 25 auxiliary auxiliary JJ cord-015021-pol2qm74 1417 26 role role NN cord-015021-pol2qm74 1417 27 for for IN cord-015021-pol2qm74 1417 28 y/~ y/~ NNP cord-015021-pol2qm74 1417 29 T T NNP cord-015021-pol2qm74 1417 30 cells cell NNS cord-015021-pol2qm74 1417 31 appears appear VBZ cord-015021-pol2qm74 1417 32 likely likely JJ cord-015021-pol2qm74 1417 33 . . . cord-015021-pol2qm74 1418 1 The the DT cord-015021-pol2qm74 1418 2 c~//3 c~//3 NNP cord-015021-pol2qm74 1418 3 T t NN cord-015021-pol2qm74 1418 4 cell cell NN cord-015021-pol2qm74 1418 5 population population NN cord-015021-pol2qm74 1418 6 further further RB cord-015021-pol2qm74 1418 7 segregates segregate VBZ cord-015021-pol2qm74 1418 8 into into IN cord-015021-pol2qm74 1418 9 CD4 CD4 NNP cord-015021-pol2qm74 1418 10 T T NNP cord-015021-pol2qm74 1418 11 cells cell NNS cord-015021-pol2qm74 1418 12 which which WDT cord-015021-pol2qm74 1418 13 recognize recognize VBP cord-015021-pol2qm74 1418 14 microbial microbial JJ cord-015021-pol2qm74 1418 15 peptides peptide NNS cord-015021-pol2qm74 1418 16 in in IN cord-015021-pol2qm74 1418 17 the the DT cord-015021-pol2qm74 1418 18 context context NN cord-015021-pol2qm74 1418 19 of of IN cord-015021-pol2qm74 1418 20 gene gene NN cord-015021-pol2qm74 1418 21 products product NNS cord-015021-pol2qm74 1418 22 of of IN cord-015021-pol2qm74 1418 23 the the DT cord-015021-pol2qm74 1418 24 major major JJ cord-015021-pol2qm74 1418 25 histocompatibility histocompatibility NN cord-015021-pol2qm74 1418 26 complex complex NN cord-015021-pol2qm74 1418 27 ( ( -LRB- cord-015021-pol2qm74 1418 28 MHC MHC NNP cord-015021-pol2qm74 1418 29 ) ) -RRB- cord-015021-pol2qm74 1418 30 and and CC cord-015021-pol2qm74 1418 31 CD8 CD8 NNP cord-015021-pol2qm74 1418 32 T T NNP cord-015021-pol2qm74 1418 33 cells cell NNS cord-015021-pol2qm74 1418 34 which which WDT cord-015021-pol2qm74 1418 35 see see VBP cord-015021-pol2qm74 1418 36 their -PRON- PRP$ cord-015021-pol2qm74 1418 37 peptide peptide NN cord-015021-pol2qm74 1418 38 in in IN cord-015021-pol2qm74 1418 39 the the DT cord-015021-pol2qm74 1418 40 context context NN cord-015021-pol2qm74 1418 41 of of IN cord-015021-pol2qm74 1418 42 MHC MHC NNP cord-015021-pol2qm74 1418 43 class class NN cord-015021-pol2qm74 1418 44 I. i. NN cord-015021-pol2qm74 1419 1 The the DT cord-015021-pol2qm74 1419 2 -y/~ -y/~ NN cord-015021-pol2qm74 1419 3 T t NN cord-015021-pol2qm74 1419 4 cells cell NNS cord-015021-pol2qm74 1419 5 are be VBP cord-015021-pol2qm74 1419 6 generally generally RB cord-015021-pol2qm74 1419 7 double double JJ cord-015021-pol2qm74 1419 8 - - HYPH cord-015021-pol2qm74 1419 9 negative negative JJ cord-015021-pol2qm74 1419 10 . . . cord-015021-pol2qm74 1420 1 Knock knock VB cord-015021-pol2qm74 1420 2 - - HYPH cord-015021-pol2qm74 1420 3 out out RP cord-015021-pol2qm74 1420 4 mice mouse NNS cord-015021-pol2qm74 1420 5 in in IN cord-015021-pol2qm74 1420 6 which which WDT cord-015021-pol2qm74 1420 7 the the DT cord-015021-pol2qm74 1420 8 genes gene NNS cord-015021-pol2qm74 1420 9 for for IN cord-015021-pol2qm74 1420 10 various various JJ cord-015021-pol2qm74 1420 11 T t NN cord-015021-pol2qm74 1420 12 cell cell NN cord-015021-pol2qm74 1420 13 receptor receptor NN cord-015021-pol2qm74 1420 14 chains chain NNS cord-015021-pol2qm74 1420 15 , , , cord-015021-pol2qm74 1420 16 for for IN cord-015021-pol2qm74 1420 17 MHC MHC NNP cord-015021-pol2qm74 1420 18 class class NN cord-015021-pol2qm74 1420 19 I I NNP cord-015021-pol2qm74 1420 20 or or CC cord-015021-pol2qm74 1420 21 MHC MHC NNP cord-015021-pol2qm74 1420 22 class class NN cord-015021-pol2qm74 1420 23 II II NNP cord-015021-pol2qm74 1420 24 molecules molecule NNS cord-015021-pol2qm74 1420 25 , , , cord-015021-pol2qm74 1420 26 for for IN cord-015021-pol2qm74 1420 27 cytokines cytokine NNS cord-015021-pol2qm74 1420 28 or or CC cord-015021-pol2qm74 1420 29 cytokine cytokine NN cord-015021-pol2qm74 1420 30 receptors receptor NNS cord-015021-pol2qm74 1420 31 had have VBD cord-015021-pol2qm74 1420 32 been be VBN cord-015021-pol2qm74 1420 33 deleted delete VBN cord-015021-pol2qm74 1420 34 , , , cord-015021-pol2qm74 1420 35 have have VBP cord-015021-pol2qm74 1420 36 provided provide VBN cord-015021-pol2qm74 1420 37 extremely extremely RB cord-015021-pol2qm74 1420 38 helpful helpful JJ cord-015021-pol2qm74 1420 39 tools tool NNS cord-015021-pol2qm74 1420 40 for for IN cord-015021-pol2qm74 1420 41 analyzing analyze VBG cord-015021-pol2qm74 1420 42 the the DT cord-015021-pol2qm74 1420 43 role role NN cord-015021-pol2qm74 1420 44 of of IN cord-015021-pol2qm74 1420 45 T T NNP cord-015021-pol2qm74 1420 46 cell cell NN cord-015021-pol2qm74 1420 47 subsets subset NNS cord-015021-pol2qm74 1420 48 and and CC cord-015021-pol2qm74 1420 49 cytokines cytokine NNS cord-015021-pol2qm74 1420 50 in in IN cord-015021-pol2qm74 1420 51 antimicrobial antimicrobial JJ cord-015021-pol2qm74 1420 52 immunity immunity NN cord-015021-pol2qm74 1420 53 . . . cord-015021-pol2qm74 1421 1 Using use VBG cord-015021-pol2qm74 1421 2 these these DT cord-015021-pol2qm74 1421 3 mutant mutant JJ cord-015021-pol2qm74 1421 4 mice mouse NNS cord-015021-pol2qm74 1421 5 , , , cord-015021-pol2qm74 1421 6 the the DT cord-015021-pol2qm74 1421 7 role role NN cord-015021-pol2qm74 1421 8 of of IN cord-015021-pol2qm74 1421 9 distinct distinct JJ cord-015021-pol2qm74 1421 10 T t NN cord-015021-pol2qm74 1421 11 cell cell NN cord-015021-pol2qm74 1421 12 subsets subset NNS cord-015021-pol2qm74 1421 13 and and CC cord-015021-pol2qm74 1421 14 cytokines cytokine NNS cord-015021-pol2qm74 1421 15 in in IN cord-015021-pol2qm74 1421 16 bacterial bacterial JJ cord-015021-pol2qm74 1421 17 elimination elimination NN cord-015021-pol2qm74 1421 18 and and CC cord-015021-pol2qm74 1421 19 granuloma granuloma NN cord-015021-pol2qm74 1421 20 formation formation NN cord-015021-pol2qm74 1421 21 was be VBD cord-015021-pol2qm74 1421 22 analyzed analyze VBN cord-015021-pol2qm74 1421 23 in in IN cord-015021-pol2qm74 1421 24 detail detail NN cord-015021-pol2qm74 1421 25 . . . cord-015021-pol2qm74 1422 1 These these DT cord-015021-pol2qm74 1422 2 studies study NNS cord-015021-pol2qm74 1422 3 underline underline VBP cord-015021-pol2qm74 1422 4 the the DT cord-015021-pol2qm74 1422 5 central central JJ cord-015021-pol2qm74 1422 6 role role NN cord-015021-pol2qm74 1422 7 of of IN cord-015021-pol2qm74 1422 8 a//3 a//3 , cord-015021-pol2qm74 1422 9 T T NNP cord-015021-pol2qm74 1422 10 cells cell NNS cord-015021-pol2qm74 1422 11 and and CC cord-015021-pol2qm74 1422 12 IFN IFN NNP cord-015021-pol2qm74 1422 13 - - HYPH cord-015021-pol2qm74 1422 14 y y NNP cord-015021-pol2qm74 1422 15 in in IN cord-015021-pol2qm74 1422 16 antibacterial antibacterial JJ cord-015021-pol2qm74 1422 17 immunity immunity NN cord-015021-pol2qm74 1422 18 and and CC cord-015021-pol2qm74 1422 19 , , , cord-015021-pol2qm74 1422 20 furthermore furthermore RB cord-015021-pol2qm74 1422 21 , , , cord-015021-pol2qm74 1422 22 show show VBP cord-015021-pol2qm74 1422 23 a a DT cord-015021-pol2qm74 1422 24 distinct distinct JJ cord-015021-pol2qm74 1422 25 function function NN cord-015021-pol2qm74 1422 26 of of IN cord-015021-pol2qm74 1422 27 7/$ 7/$ NNS cord-015021-pol2qm74 1422 28 T T NNP cord-015021-pol2qm74 1422 29 cells cell NNS cord-015021-pol2qm74 1422 30 . . . cord-015021-pol2qm74 1423 1 Moreover moreover RB cord-015021-pol2qm74 1423 2 , , , cord-015021-pol2qm74 1423 3 these these DT cord-015021-pol2qm74 1423 4 studies study NNS cord-015021-pol2qm74 1423 5 show show VBP cord-015021-pol2qm74 1423 6 that that IN cord-015021-pol2qm74 1423 7 the the DT cord-015021-pol2qm74 1423 8 relative relative JJ cord-015021-pol2qm74 1423 9 contribution contribution NN cord-015021-pol2qm74 1423 10 of of IN cord-015021-pol2qm74 1423 11 CD8 CD8 NNP cord-015021-pol2qm74 1423 12 or or CC cord-015021-pol2qm74 1423 13 CD4 CD4 NNP cord-015021-pol2qm74 1423 14 T T NNP cord-015021-pol2qm74 1423 15 cells cell NNS cord-015021-pol2qm74 1423 16 to to IN cord-015021-pol2qm74 1423 17 antimicrobial antimicrobial JJ cord-015021-pol2qm74 1423 18 immunity immunity NN cord-015021-pol2qm74 1423 19 varies vary VBZ cord-015021-pol2qm74 1423 20 in in IN cord-015021-pol2qm74 1423 21 response response NN cord-015021-pol2qm74 1423 22 to to IN cord-015021-pol2qm74 1423 23 different different JJ cord-015021-pol2qm74 1423 24 pathogens pathogen NNS cord-015021-pol2qm74 1423 25 . . . cord-015021-pol2qm74 1424 1 Apoptosis apoptosis NN cord-015021-pol2qm74 1424 2 is be VBZ cord-015021-pol2qm74 1424 3 an an DT cord-015021-pol2qm74 1424 4 active active JJ cord-015021-pol2qm74 1424 5 form form NN cord-015021-pol2qm74 1424 6 of of IN cord-015021-pol2qm74 1424 7 cell cell NN cord-015021-pol2qm74 1424 8 death death NN cord-015021-pol2qm74 1424 9 in in IN cord-015021-pol2qm74 1424 10 which which WDT cord-015021-pol2qm74 1424 11 the the DT cord-015021-pol2qm74 1424 12 cell cell NN cord-015021-pol2qm74 1424 13 participates participate VBZ cord-015021-pol2qm74 1424 14 in in IN cord-015021-pol2qm74 1424 15 its -PRON- PRP$ cord-015021-pol2qm74 1424 16 own own JJ cord-015021-pol2qm74 1424 17 demise demise NN cord-015021-pol2qm74 1424 18 , , , cord-015021-pol2qm74 1424 19 providing provide VBG cord-015021-pol2qm74 1424 20 the the DT cord-015021-pol2qm74 1424 21 biochemical biochemical JJ cord-015021-pol2qm74 1424 22 pathways pathway NNS cord-015021-pol2qm74 1424 23 that that WDT cord-015021-pol2qm74 1424 24 trigger trigger VBP cord-015021-pol2qm74 1424 25 and and CC cord-015021-pol2qm74 1424 26 mediate mediate VB cord-015021-pol2qm74 1424 27 the the DT cord-015021-pol2qm74 1424 28 complex complex JJ cord-015021-pol2qm74 1424 29 events event NNS cord-015021-pol2qm74 1424 30 of of IN cord-015021-pol2qm74 1424 31 the the DT cord-015021-pol2qm74 1424 32 process process NN cord-015021-pol2qm74 1424 33 . . . cord-015021-pol2qm74 1425 1 Although although IN cord-015021-pol2qm74 1425 2 this this DT cord-015021-pol2qm74 1425 3 phenomenon phenomenon NN cord-015021-pol2qm74 1425 4 has have VBZ cord-015021-pol2qm74 1425 5 been be VBN cord-015021-pol2qm74 1425 6 studied study VBN cord-015021-pol2qm74 1425 7 for for IN cord-015021-pol2qm74 1425 8 many many JJ cord-015021-pol2qm74 1425 9 years year NNS cord-015021-pol2qm74 1425 10 , , , cord-015021-pol2qm74 1425 11 it -PRON- PRP cord-015021-pol2qm74 1425 12 is be VBZ cord-015021-pol2qm74 1425 13 only only RB cord-015021-pol2qm74 1425 14 recently recently RB cord-015021-pol2qm74 1425 15 that that IN cord-015021-pol2qm74 1425 16 significant significant JJ cord-015021-pol2qm74 1425 17 progress progress NN cord-015021-pol2qm74 1425 18 has have VBZ cord-015021-pol2qm74 1425 19 been be VBN cord-015021-pol2qm74 1425 20 made make VBN cord-015021-pol2qm74 1425 21 towards towards IN cord-015021-pol2qm74 1425 22 the the DT cord-015021-pol2qm74 1425 23 elucidation elucidation NN cord-015021-pol2qm74 1425 24 of of IN cord-015021-pol2qm74 1425 25 the the DT cord-015021-pol2qm74 1425 26 molecular molecular JJ cord-015021-pol2qm74 1425 27 mechanisms mechanism NNS cord-015021-pol2qm74 1425 28 that that WDT cord-015021-pol2qm74 1425 29 control control VBP cord-015021-pol2qm74 1425 30 apoptosis apoptosis NN cord-015021-pol2qm74 1425 31 . . . cord-015021-pol2qm74 1426 1 Once once IN cord-015021-pol2qm74 1426 2 such such JJ cord-015021-pol2qm74 1426 3 mechanism mechanism NN cord-015021-pol2qm74 1426 4 came come VBD cord-015021-pol2qm74 1426 5 as as IN cord-015021-pol2qm74 1426 6 something something NN cord-015021-pol2qm74 1426 7 of of IN cord-015021-pol2qm74 1426 8 a a DT cord-015021-pol2qm74 1426 9 surprise surprise NN cord-015021-pol2qm74 1426 10 : : : cord-015021-pol2qm74 1426 11 in in IN cord-015021-pol2qm74 1426 12 a a DT cord-015021-pol2qm74 1426 13 number number NN cord-015021-pol2qm74 1426 14 of of IN cord-015021-pol2qm74 1426 15 eases ease NNS cord-015021-pol2qm74 1426 16 , , , cord-015021-pol2qm74 1426 17 apoptosis apoptosis NN cord-015021-pol2qm74 1426 18 can can MD cord-015021-pol2qm74 1426 19 be be VB cord-015021-pol2qm74 1426 20 promoted promote VBN cord-015021-pol2qm74 1426 21 by by IN cord-015021-pol2qm74 1426 22 the the DT cord-015021-pol2qm74 1426 23 action action NN cord-015021-pol2qm74 1426 24 of of IN cord-015021-pol2qm74 1426 25 the the DT cord-015021-pol2qm74 1426 26 c c NNP cord-015021-pol2qm74 1426 27 - - HYPH cord-015021-pol2qm74 1426 28 Myc Myc NNP cord-015021-pol2qm74 1426 29 protein protein NN cord-015021-pol2qm74 1426 30 , , , cord-015021-pol2qm74 1426 31 a a DT cord-015021-pol2qm74 1426 32 protooncogene protooncogene JJ cord-015021-pol2qm74 1426 33 product product NN cord-015021-pol2qm74 1426 34 that that WDT cord-015021-pol2qm74 1426 35 had have VBD cord-015021-pol2qm74 1426 36 previously previously RB cord-015021-pol2qm74 1426 37 been be VBN cord-015021-pol2qm74 1426 38 associated associate VBN cord-015021-pol2qm74 1426 39 only only RB cord-015021-pol2qm74 1426 40 with with IN cord-015021-pol2qm74 1426 41 cell cell NN cord-015021-pol2qm74 1426 42 proliferation proliferation NN cord-015021-pol2qm74 1426 43 ( ( -LRB- cord-015021-pol2qm74 1426 44 and and CC cord-015021-pol2qm74 1426 45 presumably presumably RB cord-015021-pol2qm74 1426 46 , , , cord-015021-pol2qm74 1426 47 survival survival NN cord-015021-pol2qm74 1426 48 ) ) -RRB- cord-015021-pol2qm74 1426 49 . . . cord-015021-pol2qm74 1427 1 Expression expression NN cord-015021-pol2qm74 1427 2 of of IN cord-015021-pol2qm74 1427 3 c. c. NN cord-015021-pol2qm74 1428 1 Myc Myc NNP cord-015021-pol2qm74 1428 2 in in IN cord-015021-pol2qm74 1428 3 cells cell NNS cord-015021-pol2qm74 1428 4 can can MD cord-015021-pol2qm74 1428 5 cause cause VB cord-015021-pol2qm74 1428 6 them -PRON- PRP cord-015021-pol2qm74 1428 7 to to TO cord-015021-pol2qm74 1428 8 enter enter VB cord-015021-pol2qm74 1428 9 an an DT cord-015021-pol2qm74 1428 10 apoptotic apoptotic JJ cord-015021-pol2qm74 1428 11 pathway pathway NN cord-015021-pol2qm74 1428 12 or or CC cord-015021-pol2qm74 1428 13 proliferate proliferate VBP cord-015021-pol2qm74 1428 14 , , , cord-015021-pol2qm74 1428 15 mad mad JJ cord-015021-pol2qm74 1428 16 this this DT cord-015021-pol2qm74 1428 17 " " `` cord-015021-pol2qm74 1428 18 decision decision NN cord-015021-pol2qm74 1428 19 " " '' cord-015021-pol2qm74 1428 20 depends depend VBZ cord-015021-pol2qm74 1428 21 upon upon IN cord-015021-pol2qm74 1428 22 additional additional JJ cord-015021-pol2qm74 1428 23 signals signal NNS cord-015021-pol2qm74 1428 24 , , , cord-015021-pol2qm74 1428 25 such such JJ cord-015021-pol2qm74 1428 26 as as IN cord-015021-pol2qm74 1428 27 growth growth NN cord-015021-pol2qm74 1428 28 factors factor NNS cord-015021-pol2qm74 1428 29 that that WDT cord-015021-pol2qm74 1428 30 inhibit inhibit VBP cord-015021-pol2qm74 1428 31 apoptosis apoptosis NN cord-015021-pol2qm74 1428 32 and and CC cord-015021-pol2qm74 1428 33 allow allow VB cord-015021-pol2qm74 1428 34 the the DT cord-015021-pol2qm74 1428 35 ceils ceil NNS cord-015021-pol2qm74 1428 36 to to TO cord-015021-pol2qm74 1428 37 proliferate proliferate VB cord-015021-pol2qm74 1428 38 . . . cord-015021-pol2qm74 1429 1 Thus thus RB cord-015021-pol2qm74 1429 2 , , , cord-015021-pol2qm74 1429 3 c c NN cord-015021-pol2qm74 1429 4 - - HYPH cord-015021-pol2qm74 1429 5 Myc Myc NNP cord-015021-pol2qm74 1429 6 directs direct VBZ cord-015021-pol2qm74 1429 7 cells cell NNS cord-015021-pol2qm74 1429 8 out out IN cord-015021-pol2qm74 1429 9 of of IN cord-015021-pol2qm74 1429 10 rest rest NN cord-015021-pol2qm74 1429 11 and and CC cord-015021-pol2qm74 1429 12 the the DT cord-015021-pol2qm74 1429 13 choice choice NN cord-015021-pol2qm74 1429 14 of of IN cord-015021-pol2qm74 1429 15 proliferation proliferation NN cord-015021-pol2qm74 1429 16 or or CC cord-015021-pol2qm74 1429 17 death death NN cord-015021-pol2qm74 1429 18 depends depend VBZ cord-015021-pol2qm74 1429 19 upon upon IN cord-015021-pol2qm74 1429 20 the the DT cord-015021-pol2qm74 1429 21 presence presence NN cord-015021-pol2qm74 1429 22 or or CC cord-015021-pol2qm74 1429 23 absence absence NN cord-015021-pol2qm74 1429 24 of of IN cord-015021-pol2qm74 1429 25 survival survival NN cord-015021-pol2qm74 1429 26 signals signal NNS cord-015021-pol2qm74 1429 27 . . . cord-015021-pol2qm74 1430 1 Other other JJ cord-015021-pol2qm74 1430 2 survival survival NN cord-015021-pol2qm74 1430 3 signals signal NNS cord-015021-pol2qm74 1430 4 are be VBP cord-015021-pol2qm74 1430 5 generated generate VBN cord-015021-pol2qm74 1430 6 by by IN cord-015021-pol2qm74 1430 7 oncogene oncogene NN cord-015021-pol2qm74 1430 8 productS productS NNP cord-015021-pol2qm74 1430 9 that that WDT cord-015021-pol2qm74 1430 10 can can MD cord-015021-pol2qm74 1430 11 cooperate cooperate VB cord-015021-pol2qm74 1430 12 with with IN cord-015021-pol2qm74 1430 13 My¢ My¢ NNS cord-015021-pol2qm74 1430 14 , , , cord-015021-pol2qm74 1430 15 including include VBG cord-015021-pol2qm74 1430 16 Bcl-2 Bcl-2 NNP cord-015021-pol2qm74 1430 17 and and CC cord-015021-pol2qm74 1430 18 AbL abl NN cord-015021-pol2qm74 1431 1 There there EX cord-015021-pol2qm74 1431 2 are be VBP cord-015021-pol2qm74 1431 3 implications implication NNS cord-015021-pol2qm74 1431 4 of of IN cord-015021-pol2qm74 1431 5 this this DT cord-015021-pol2qm74 1431 6 interplay interplay NN cord-015021-pol2qm74 1431 7 between between IN cord-015021-pol2qm74 1431 8 apoptotie apoptotie NN cord-015021-pol2qm74 1431 9 and and CC cord-015021-pol2qm74 1431 10 anti anti JJ cord-015021-pol2qm74 1431 11 - - JJ cord-015021-pol2qm74 1431 12 apoptorlc apoptorlc JJ cord-015021-pol2qm74 1431 13 signals signal NNS cord-015021-pol2qm74 1431 14 in in IN cord-015021-pol2qm74 1431 15 cell cell NN cord-015021-pol2qm74 1431 16 Iransformation Iransformation NNP cord-015021-pol2qm74 1431 17 and and CC cord-015021-pol2qm74 1431 18 the the DT cord-015021-pol2qm74 1431 19 resistance resistance NN cord-015021-pol2qm74 1431 20 of of IN cord-015021-pol2qm74 1431 21 some some DT cord-015021-pol2qm74 1431 22 tumor tumor NN cord-015021-pol2qm74 1431 23 ceils ceil NNS cord-015021-pol2qm74 1431 24 to to IN cord-015021-pol2qm74 1431 25 therapeutic therapeutic JJ cord-015021-pol2qm74 1431 26 agents agent NNS cord-015021-pol2qm74 1431 27 capable capable JJ cord-015021-pol2qm74 1431 28 of of IN cord-015021-pol2qm74 1431 29 inducing induce VBG cord-015021-pol2qm74 1431 30 apoptosis apoptosis NN cord-015021-pol2qm74 1431 31 . . . cord-015021-pol2qm74 1432 1 Oncogene oncogene NN cord-015021-pol2qm74 1432 2 interactions interaction NNS cord-015021-pol2qm74 1432 3 therefore therefore RB cord-015021-pol2qm74 1432 4 control control VBP cord-015021-pol2qm74 1432 5 the the DT cord-015021-pol2qm74 1432 6 life life NN cord-015021-pol2qm74 1432 7 or or CC cord-015021-pol2qm74 1432 8 death death NN cord-015021-pol2qm74 1432 9 of of IN cord-015021-pol2qm74 1432 10 transformed transformed JJ cord-015021-pol2qm74 1432 11 ceils ceil NNS cord-015021-pol2qm74 1432 12 but but CC cord-015021-pol2qm74 1432 13 also also RB cord-015021-pol2qm74 1432 14 have have VBP cord-015021-pol2qm74 1432 15 important important JJ cord-015021-pol2qm74 1432 16 roles role NNS cord-015021-pol2qm74 1432 17 in in IN cord-015021-pol2qm74 1432 18 normal normal JJ cord-015021-pol2qm74 1432 19 , , , cord-015021-pol2qm74 1432 20 development development NN cord-015021-pol2qm74 1432 21 processes process NNS cord-015021-pol2qm74 1432 22 . . . cord-015021-pol2qm74 1433 1 In in IN cord-015021-pol2qm74 1433 2 the the DT cord-015021-pol2qm74 1433 3 immune immune JJ cord-015021-pol2qm74 1433 4 system system NN cord-015021-pol2qm74 1433 5 , , , cord-015021-pol2qm74 1433 6 developing develop VBG cord-015021-pol2qm74 1433 7 T T NNP cord-015021-pol2qm74 1433 8 ceils ceil NNS cord-015021-pol2qm74 1433 9 are be VBP cord-015021-pol2qm74 1433 10 " " `` cord-015021-pol2qm74 1433 11 screened screen VBN cord-015021-pol2qm74 1433 12 " " '' cord-015021-pol2qm74 1433 13 for for IN cord-015021-pol2qm74 1433 14 potential potential JJ cord-015021-pol2qm74 1433 15 self self NN cord-015021-pol2qm74 1433 16 - - HYPH cord-015021-pol2qm74 1433 17 reactivity reactivity NN cord-015021-pol2qm74 1433 18 by by IN cord-015021-pol2qm74 1433 19 a a DT cord-015021-pol2qm74 1433 20 process process NN cord-015021-pol2qm74 1433 21 of of IN cord-015021-pol2qm74 1433 22 negative negative JJ cord-015021-pol2qm74 1433 23 selection selection NN cord-015021-pol2qm74 1433 24 , , , cord-015021-pol2qm74 1433 25 in in IN cord-015021-pol2qm74 1433 26 which which WDT cord-015021-pol2qm74 1433 27 activation activation NN cord-015021-pol2qm74 1433 28 via via IN cord-015021-pol2qm74 1433 29 the the DT cord-015021-pol2qm74 1433 30 T T NNP cord-015021-pol2qm74 1433 31 cell cell NN cord-015021-pol2qm74 1433 32 receptor receptor NN cord-015021-pol2qm74 1433 33 ( ( -LRB- cord-015021-pol2qm74 1433 34 TCR TCR NNP cord-015021-pol2qm74 1433 35 ) ) -RRB- cord-015021-pol2qm74 1433 36 induces induce VBZ cord-015021-pol2qm74 1433 37 apoptosis apoptosis NN cord-015021-pol2qm74 1433 38 . . . cord-015021-pol2qm74 1434 1 This this DT cord-015021-pol2qm74 1434 2 process process NN cord-015021-pol2qm74 1434 3 can can MD cord-015021-pol2qm74 1434 4 be be VB cord-015021-pol2qm74 1434 5 mimicked mimic VBN cord-015021-pol2qm74 1434 6 in in IN cord-015021-pol2qm74 1434 7 T T NNP cord-015021-pol2qm74 1434 8 cell cell NN cord-015021-pol2qm74 1434 9 hybridomas hybridomas NN cord-015021-pol2qm74 1434 10 , , , cord-015021-pol2qm74 1434 11 and and CC cord-015021-pol2qm74 1434 12 appears appear VBZ cord-015021-pol2qm74 1434 13 to to TO cord-015021-pol2qm74 1434 14 depend depend VB cord-015021-pol2qm74 1434 15 upon upon IN cord-015021-pol2qm74 1434 16 the the DT cord-015021-pol2qm74 1434 17 expression expression NN cord-015021-pol2qm74 1434 18 of of IN cord-015021-pol2qm74 1434 19 the the DT cord-015021-pol2qm74 1434 20 c c NNP cord-015021-pol2qm74 1434 21 - - HYPH cord-015021-pol2qm74 1434 22 Mye Mye NNP cord-015021-pol2qm74 1434 23 protein protein NN cord-015021-pol2qm74 1434 24 . . . cord-015021-pol2qm74 1435 1 Evidence evidence NN cord-015021-pol2qm74 1435 2 that that IN cord-015021-pol2qm74 1435 3 this this DT cord-015021-pol2qm74 1435 4 represents represent VBZ cord-015021-pol2qm74 1435 5 a a DT cord-015021-pol2qm74 1435 6 requirement requirement NN cord-015021-pol2qm74 1435 7 for for IN cord-015021-pol2qm74 1435 8 the the DT cord-015021-pol2qm74 1435 9 Myc Myc NNP cord-015021-pol2qm74 1435 10 / / SYM cord-015021-pol2qm74 1435 11 Max Max NNP cord-015021-pol2qm74 1435 12 heterodimer heterodimer NN cord-015021-pol2qm74 1435 13 will will MD cord-015021-pol2qm74 1435 14 be be VB cord-015021-pol2qm74 1435 15 presented present VBN cord-015021-pol2qm74 1435 16 . . . cord-015021-pol2qm74 1436 1 As as IN cord-015021-pol2qm74 1436 2 above above RB cord-015021-pol2qm74 1436 3 , , , cord-015021-pol2qm74 1436 4 these these DT cord-015021-pol2qm74 1436 5 cells cell NNS cord-015021-pol2qm74 1436 6 are be VBP cord-015021-pol2qm74 1436 7 presented present VBN cord-015021-pol2qm74 1436 8 with with IN cord-015021-pol2qm74 1436 9 the the DT cord-015021-pol2qm74 1436 10 " " `` cord-015021-pol2qm74 1436 11 choice choice NN cord-015021-pol2qm74 1436 12 " " '' cord-015021-pol2qm74 1436 13 to to TO cord-015021-pol2qm74 1436 14 proliferate proliferate VB cord-015021-pol2qm74 1436 15 or or CC cord-015021-pol2qm74 1436 16 die die VB cord-015021-pol2qm74 1436 17 and and CC cord-015021-pol2qm74 1436 18 this this DT cord-015021-pol2qm74 1436 19 depends depend VBZ cord-015021-pol2qm74 1436 20 not not RB cord-015021-pol2qm74 1436 21 only only RB cord-015021-pol2qm74 1436 22 upon upon IN cord-015021-pol2qm74 1436 23 Myc Myc NNP cord-015021-pol2qm74 1436 24 but but CC cord-015021-pol2qm74 1436 25 also also RB cord-015021-pol2qm74 1436 26 other other JJ cord-015021-pol2qm74 1436 27 signals signal NNS cord-015021-pol2qm74 1436 28 . . . cord-015021-pol2qm74 1437 1 Thus thus RB cord-015021-pol2qm74 1437 2 , , , cord-015021-pol2qm74 1437 3 expression expression NN cord-015021-pol2qm74 1437 4 of of IN cord-015021-pol2qm74 1437 5 functional functional JJ cord-015021-pol2qm74 1437 6 v v NN cord-015021-pol2qm74 1437 7 - - : cord-015021-pol2qm74 1437 8 AN an DT cord-015021-pol2qm74 1437 9 kinase kinase NN cord-015021-pol2qm74 1437 10 in in IN cord-015021-pol2qm74 1437 11 these these DT cord-015021-pol2qm74 1437 12 ceils ceil NNS cord-015021-pol2qm74 1437 13 can can MD cord-015021-pol2qm74 1437 14 render render VB cord-015021-pol2qm74 1437 15 them -PRON- PRP cord-015021-pol2qm74 1437 16 resistant resistant JJ cord-015021-pol2qm74 1437 17 to to IN cord-015021-pol2qm74 1437 18 the the DT cord-015021-pol2qm74 1437 19 activation activation NN cord-015021-pol2qm74 1437 20 of of IN cord-015021-pol2qm74 1437 21 apoptosis apoptosis NN cord-015021-pol2qm74 1437 22 via via IN cord-015021-pol2qm74 1437 23 TCR TCR NNP cord-015021-pol2qm74 1437 24 ligation ligation NN cord-015021-pol2qm74 1437 25 , , , cord-015021-pol2qm74 1437 26 Surprisingly surprisingly RB cord-015021-pol2qm74 1437 27 , , , cord-015021-pol2qm74 1437 28 Bcl-2 Bcl-2 NNP cord-015021-pol2qm74 1437 29 does do VBZ cord-015021-pol2qm74 1437 30 not not RB cord-015021-pol2qm74 1437 31 appear appear VB cord-015021-pol2qm74 1437 32 to to TO cord-015021-pol2qm74 1437 33 be be VB cord-015021-pol2qm74 1437 34 capable capable JJ cord-015021-pol2qm74 1437 35 of of IN cord-015021-pol2qm74 1437 36 blocking block VBG cord-015021-pol2qm74 1437 37 this this DT cord-015021-pol2qm74 1437 38 form form NN cord-015021-pol2qm74 1437 39 of of IN cord-015021-pol2qm74 1437 40 apoptosis apoptosis NN cord-015021-pol2qm74 1437 41 , , , cord-015021-pol2qm74 1437 42 and and CC cord-015021-pol2qm74 1437 43 the the DT cord-015021-pol2qm74 1437 44 reasons reason NNS cord-015021-pol2qm74 1437 45 for for IN cord-015021-pol2qm74 1437 46 this this DT cord-015021-pol2qm74 1437 47 will will MD cord-015021-pol2qm74 1437 48 provide provide VB cord-015021-pol2qm74 1437 49 new new JJ cord-015021-pol2qm74 1437 50 insights insight NNS cord-015021-pol2qm74 1437 51 into into IN cord-015021-pol2qm74 1437 52 the the DT cord-015021-pol2qm74 1437 53 development development NN cord-015021-pol2qm74 1437 54 of of IN cord-015021-pol2qm74 1437 55 the the DT cord-015021-pol2qm74 1437 56 immune immune JJ cord-015021-pol2qm74 1437 57 system system NN cord-015021-pol2qm74 1437 58 and and CC cord-015021-pol2qm74 1437 59 the the DT cord-015021-pol2qm74 1437 60 process process NN cord-015021-pol2qm74 1437 61 of of IN cord-015021-pol2qm74 1437 62 apoptosis apoptosis NN cord-015021-pol2qm74 1437 63 . . . cord-015021-pol2qm74 1438 1 Although although IN cord-015021-pol2qm74 1438 2 the the DT cord-015021-pol2qm74 1438 3 oncogene oncogene NN cord-015021-pol2qm74 1438 4 products product NNS cord-015021-pol2qm74 1438 5 discussed discuss VBN cord-015021-pol2qm74 1438 6 here here RB cord-015021-pol2qm74 1438 7 probably probably RB cord-015021-pol2qm74 1438 8 do do VBP cord-015021-pol2qm74 1438 9 not not RB cord-015021-pol2qm74 1438 10 directly directly RB cord-015021-pol2qm74 1438 11 participate participate VB cord-015021-pol2qm74 1438 12 in in IN cord-015021-pol2qm74 1438 13 the the DT cord-015021-pol2qm74 1438 14 biochemical biochemical JJ cord-015021-pol2qm74 1438 15 process process NN cord-015021-pol2qm74 1438 16 of of IN cord-015021-pol2qm74 1438 17 apoptosis apoptosis NN cord-015021-pol2qm74 1438 18 , , , cord-015021-pol2qm74 1438 19 they -PRON- PRP cord-015021-pol2qm74 1438 20 represent represent VBP cord-015021-pol2qm74 1438 21 molecular molecular JJ cord-015021-pol2qm74 1438 22 controls control NNS cord-015021-pol2qm74 1438 23 on on IN cord-015021-pol2qm74 1438 24 this this DT cord-015021-pol2qm74 1438 25 complex complex JJ cord-015021-pol2qm74 1438 26 mechanism mechanism NN cord-015021-pol2qm74 1438 27 . . . cord-015021-pol2qm74 1439 1 As as IN cord-015021-pol2qm74 1439 2 such such JJ cord-015021-pol2qm74 1439 3 , , , cord-015021-pol2qm74 1439 4 they -PRON- PRP cord-015021-pol2qm74 1439 5 gave give VBD cord-015021-pol2qm74 1439 6 us -PRON- PRP cord-015021-pol2qm74 1439 7 new new JJ cord-015021-pol2qm74 1439 8 ways way NNS cord-015021-pol2qm74 1439 9 to to TO cord-015021-pol2qm74 1439 10 look look VB cord-015021-pol2qm74 1439 11 at at IN cord-015021-pol2qm74 1439 12 the the DT cord-015021-pol2qm74 1439 13 life life NN cord-015021-pol2qm74 1439 14 and and CC cord-015021-pol2qm74 1439 15 death death NN cord-015021-pol2qm74 1439 16 of of IN cord-015021-pol2qm74 1439 17 a a DT cord-015021-pol2qm74 1439 18 cell cell NN cord-015021-pol2qm74 1440 1 Recent recent JJ cord-015021-pol2qm74 1440 2 attention attention NN cord-015021-pol2qm74 1440 3 has have VBZ cord-015021-pol2qm74 1440 4 focused focus VBN cord-015021-pol2qm74 1440 5 on on IN cord-015021-pol2qm74 1440 6 macrophage macrophage NN cord-015021-pol2qm74 1440 7 release release NN cord-015021-pol2qm74 1440 8 of of IN cord-015021-pol2qm74 1440 9 cytokines cytokine NNS cord-015021-pol2qm74 1440 10 , , , cord-015021-pol2qm74 1440 11 such such JJ cord-015021-pol2qm74 1440 12 as as IN cord-015021-pol2qm74 1440 13 IL-1 IL-1 NNP cord-015021-pol2qm74 1440 14 , , , cord-015021-pol2qm74 1440 15 IL-6 IL-6 NNP cord-015021-pol2qm74 1440 16 and and CC cord-015021-pol2qm74 1440 17 TNF TNF NNP cord-015021-pol2qm74 1440 18 as as IN cord-015021-pol2qm74 1440 19 important important JJ cord-015021-pol2qm74 1440 20 mediators mediator NNS cord-015021-pol2qm74 1440 21 of of IN cord-015021-pol2qm74 1440 22 septic septic JJ cord-015021-pol2qm74 1440 23 shock shock NN cord-015021-pol2qm74 1440 24 . . . cord-015021-pol2qm74 1441 1 However however RB cord-015021-pol2qm74 1441 2 , , , cord-015021-pol2qm74 1441 3 serum serum NN cord-015021-pol2qm74 1441 4 cytokine cytokine NN cord-015021-pol2qm74 1441 5 levels level NNS cord-015021-pol2qm74 1441 6 have have VBP cord-015021-pol2qm74 1441 7 correlated correlate VBN cord-015021-pol2qm74 1441 8 poorly poorly RB cord-015021-pol2qm74 1441 9 with with IN cord-015021-pol2qm74 1441 10 outcome outcome NN cord-015021-pol2qm74 1441 11 of of IN cord-015021-pol2qm74 1441 12 septic septic JJ cord-015021-pol2qm74 1441 13 shock shock NN cord-015021-pol2qm74 1441 14 . . . cord-015021-pol2qm74 1442 1 The the DT cord-015021-pol2qm74 1442 2 purpose purpose NN cord-015021-pol2qm74 1442 3 of of IN cord-015021-pol2qm74 1442 4 this this DT cord-015021-pol2qm74 1442 5 study study NN cord-015021-pol2qm74 1442 6 was be VBD cord-015021-pol2qm74 1442 7 to to TO cord-015021-pol2qm74 1442 8 compare compare VB cord-015021-pol2qm74 1442 9 the the DT cord-015021-pol2qm74 1442 10 functional functional JJ cord-015021-pol2qm74 1442 11 status status NN cord-015021-pol2qm74 1442 12 of of IN cord-015021-pol2qm74 1442 13 macrophages macrophage NNS cord-015021-pol2qm74 1442 14 to to IN cord-015021-pol2qm74 1442 15 serum serum VB cord-015021-pol2qm74 1442 16 cytokine cytokine JJ cord-015021-pol2qm74 1442 17 levels level NNS cord-015021-pol2qm74 1442 18 in in IN cord-015021-pol2qm74 1442 19 early early JJ cord-015021-pol2qm74 1442 20 sepsis sepsis NN cord-015021-pol2qm74 1442 21 by by IN cord-015021-pol2qm74 1442 22 an an DT cord-015021-pol2qm74 1442 23 analysis analysis NN cord-015021-pol2qm74 1442 24 of of IN cord-015021-pol2qm74 1442 25 splenic splenic JJ cord-015021-pol2qm74 1442 26 macrophage macrophage NN cord-015021-pol2qm74 1442 27 protein protein NN cord-015021-pol2qm74 1442 28 synthesis synthesis NN cord-015021-pol2qm74 1442 29 during during IN cord-015021-pol2qm74 1442 30 abdominal abdominal JJ cord-015021-pol2qm74 1442 31 sepsis sepsis NN cord-015021-pol2qm74 1442 32 . . . cord-015021-pol2qm74 1443 1 Macrophage macrophage NN cord-015021-pol2qm74 1443 2 total total JJ cord-015021-pol2qm74 1443 3 protein protein NN cord-015021-pol2qm74 1443 4 distribution distribution NN cord-015021-pol2qm74 1443 5 and and CC cord-015021-pol2qm74 1443 6 biosynthetic biosynthetic JJ cord-015021-pol2qm74 1443 7 activity activity NN cord-015021-pol2qm74 1443 8 was be VBD cord-015021-pol2qm74 1443 9 assessed assess VBN cord-015021-pol2qm74 1443 10 by by IN cord-015021-pol2qm74 1443 11 large large JJ cord-015021-pol2qm74 1443 12 format format NN cord-015021-pol2qm74 1443 13 2-D 2-D NNP cord-015021-pol2qm74 1443 14 PAGE page NN cord-015021-pol2qm74 1443 15 , , , cord-015021-pol2qm74 1443 16 autoradiography autoradiography NN cord-015021-pol2qm74 1443 17 of of IN cord-015021-pol2qm74 1443 18 35S 35S NNP cord-015021-pol2qm74 1443 19 - - HYPH cord-015021-pol2qm74 1443 20 labeled label VBN cord-015021-pol2qm74 1443 21 proteins protein NNS cord-015021-pol2qm74 1443 22 and and CC cord-015021-pol2qm74 1443 23 computer computer NN cord-015021-pol2qm74 1443 24 assisted assist VBN cord-015021-pol2qm74 1443 25 densitometric densitometric JJ cord-015021-pol2qm74 1443 26 analysis analysis NN cord-015021-pol2qm74 1443 27 . . . cord-015021-pol2qm74 1444 1 Sepsis sepsis NN cord-015021-pol2qm74 1444 2 was be VBD cord-015021-pol2qm74 1444 3 induced induce VBN cord-015021-pol2qm74 1444 4 in in IN cord-015021-pol2qm74 1444 5 Sprague Sprague NNP cord-015021-pol2qm74 1444 6 Dawley Dawley NNP cord-015021-pol2qm74 1444 7 mts mts NNP cord-015021-pol2qm74 1444 8 by by IN cord-015021-pol2qm74 1444 9 cecal cecal JJ cord-015021-pol2qm74 1444 10 ligation ligation NN cord-015021-pol2qm74 1444 11 and and CC cord-015021-pol2qm74 1444 12 puncture puncture NN cord-015021-pol2qm74 1444 13 ( ( -LRB- cord-015021-pol2qm74 1444 14 CLP CLP NNP cord-015021-pol2qm74 1444 15 ) ) -RRB- cord-015021-pol2qm74 1444 16 . . . cord-015021-pol2qm74 1445 1 Untreated untreated JJ cord-015021-pol2qm74 1445 2 and and CC cord-015021-pol2qm74 1445 3 sham sham NN cord-015021-pol2qm74 1445 4 operated operate VBD cord-015021-pol2qm74 1445 5 rats rat NNS cord-015021-pol2qm74 1445 6 served serve VBD cord-015021-pol2qm74 1445 7 as as IN cord-015021-pol2qm74 1445 8 controls control NNS cord-015021-pol2qm74 1445 9 . . . cord-015021-pol2qm74 1446 1 Splenic splenic JJ cord-015021-pol2qm74 1446 2 macrophages macrophage NNS cord-015021-pol2qm74 1446 3 were be VBD cord-015021-pol2qm74 1446 4 harvested harvest VBN cord-015021-pol2qm74 1446 5 at at IN cord-015021-pol2qm74 1446 6 3 3 CD cord-015021-pol2qm74 1446 7 and and CC cord-015021-pol2qm74 1446 8 24 24 CD cord-015021-pol2qm74 1446 9 hrs hrs NN cord-015021-pol2qm74 1446 10 . . . cord-015021-pol2qm74 1447 1 following follow VBG cord-015021-pol2qm74 1447 2 CLP CLP NNP cord-015021-pol2qm74 1447 3 . . . cord-015021-pol2qm74 1448 1 Serum serum NN cord-015021-pol2qm74 1448 2 IL-6 IL-6 NNP cord-015021-pol2qm74 1448 3 levels level NNS cord-015021-pol2qm74 1448 4 were be VBD cord-015021-pol2qm74 1448 5 determined determine VBN cord-015021-pol2qm74 1448 6 at at IN cord-015021-pol2qm74 1448 7 3,12 3,12 CD cord-015021-pol2qm74 1448 8 , , , cord-015021-pol2qm74 1448 9 and and CC cord-015021-pol2qm74 1448 10 24 24 CD cord-015021-pol2qm74 1448 11 hours hour NNS cord-015021-pol2qm74 1448 12 by by IN cord-015021-pol2qm74 1448 13 the the DT cord-015021-pol2qm74 1448 14 7 7 CD cord-015021-pol2qm74 1448 15 TDI TDI NNP cord-015021-pol2qm74 1448 16 bioassay bioassay NN cord-015021-pol2qm74 1448 17 . . . cord-015021-pol2qm74 1449 1 By by IN cord-015021-pol2qm74 1449 2 12 12 CD cord-015021-pol2qm74 1449 3 hrs hrs NN cord-015021-pol2qm74 1449 4 . . . cord-015021-pol2qm74 1450 1 100 100 CD cord-015021-pol2qm74 1450 2 % % NN cord-015021-pol2qm74 1450 3 of of IN cord-015021-pol2qm74 1450 4 the the DT cord-015021-pol2qm74 1450 5 CLP CLP NNP cord-015021-pol2qm74 1450 6 mls mls NNP cord-015021-pol2qm74 1450 7 exhibited exhibit VBD cord-015021-pol2qm74 1450 8 multi multi JJ cord-015021-pol2qm74 1450 9 - - JJ cord-015021-pol2qm74 1450 10 microbiaJ microbiaj JJ cord-015021-pol2qm74 1450 11 bacteremia bacteremia NN cord-015021-pol2qm74 1450 12 . . . cord-015021-pol2qm74 1451 1 Control control NN cord-015021-pol2qm74 1451 2 or or CC cord-015021-pol2qm74 1451 3 sham sham NN cord-015021-pol2qm74 1451 4 operated operate VBD cord-015021-pol2qm74 1451 5 rats rat NNS cord-015021-pol2qm74 1451 6 did do VBD cord-015021-pol2qm74 1451 7 not not RB cord-015021-pol2qm74 1451 8 show show VB cord-015021-pol2qm74 1451 9 bacteremia bacteremia NN cord-015021-pol2qm74 1451 10 . . . cord-015021-pol2qm74 1452 1 CLP CLP NNP cord-015021-pol2qm74 1452 2 resulted result VBD cord-015021-pol2qm74 1452 3 in in IN cord-015021-pol2qm74 1452 4 a a DT cord-015021-pol2qm74 1452 5 significant significant JJ cord-015021-pol2qm74 1452 6 286 286 CD cord-015021-pol2qm74 1452 7 % % NN cord-015021-pol2qm74 1452 8 elevation elevation NN cord-015021-pol2qm74 1452 9 ( ( -LRB- cord-015021-pol2qm74 1452 10 p p NN cord-015021-pol2qm74 1452 11 < < XX cord-015021-pol2qm74 1452 12 0.05 0.05 CD cord-015021-pol2qm74 1452 13 ) ) -RRB- cord-015021-pol2qm74 1452 14 in in IN cord-015021-pol2qm74 1452 15 serum serum NN cord-015021-pol2qm74 1452 16 IL-6 IL-6 NNP cord-015021-pol2qm74 1452 17 levels level NNS cord-015021-pol2qm74 1452 18 at at IN cord-015021-pol2qm74 1452 19 12 12 CD cord-015021-pol2qm74 1452 20 hrs hrs NN cord-015021-pol2qm74 1452 21 . . . cord-015021-pol2qm74 1453 1 There there EX cord-015021-pol2qm74 1453 2 was be VBD cord-015021-pol2qm74 1453 3 no no DT cord-015021-pol2qm74 1453 4 difference difference NN cord-015021-pol2qm74 1453 5 in in IN cord-015021-pol2qm74 1453 6 IL-6 IL-6 NNP cord-015021-pol2qm74 1453 7 at at IN cord-015021-pol2qm74 1453 8 3 3 CD cord-015021-pol2qm74 1453 9 and and CC cord-015021-pol2qm74 1453 10 24 24 CD cord-015021-pol2qm74 1453 11 hrs hrs NN cord-015021-pol2qm74 1453 12 . . . cord-015021-pol2qm74 1454 1 when when WRB cord-015021-pol2qm74 1454 2 compared compare VBN cord-015021-pol2qm74 1454 3 to to IN cord-015021-pol2qm74 1454 4 the the DT cord-015021-pol2qm74 1454 5 control control NN cord-015021-pol2qm74 1454 6 groups group NNS cord-015021-pol2qm74 1454 7 . . . cord-015021-pol2qm74 1455 1 2D 2D NNP cord-015021-pol2qm74 1455 2 PAGE PAGE NNP cord-015021-pol2qm74 1455 3 studies study NNS cord-015021-pol2qm74 1455 4 examined examine VBD cord-015021-pol2qm74 1455 5 splenic splenic JJ cord-015021-pol2qm74 1455 6 macrophage macrophage NN cord-015021-pol2qm74 1455 7 total total JJ cord-015021-pol2qm74 1455 8 protein protein NN cord-015021-pol2qm74 1455 9 distribution distribution NN cord-015021-pol2qm74 1455 10 and and CC cord-015021-pol2qm74 1455 11 biosynthetic biosynthetic JJ cord-015021-pol2qm74 1455 12 activity activity NN cord-015021-pol2qm74 1455 13 at at IN cord-015021-pol2qm74 1455 14 3 3 CD cord-015021-pol2qm74 1455 15 and and CC cord-015021-pol2qm74 1455 16 24 24 CD cord-015021-pol2qm74 1455 17 hrs hrs NN cord-015021-pol2qm74 1455 18 . . . cord-015021-pol2qm74 1456 1 post post JJ cord-015021-pol2qm74 1456 2 - - JJ cord-015021-pol2qm74 1456 3 CLP CLP NNP cord-015021-pol2qm74 1456 4 . . . cord-015021-pol2qm74 1457 1 At at IN cord-015021-pol2qm74 1457 2 3 3 CD cord-015021-pol2qm74 1457 3 hrs hrs NN cord-015021-pol2qm74 1457 4 . . . cord-015021-pol2qm74 1458 1 macrophages macrophage NNS cord-015021-pol2qm74 1458 2 from from IN cord-015021-pol2qm74 1458 3 CLP CLP NNP cord-015021-pol2qm74 1458 4 rats rat NNS cord-015021-pol2qm74 1458 5 showed show VBD cord-015021-pol2qm74 1458 6 a a DT cord-015021-pol2qm74 1458 7 substantial substantial JJ cord-015021-pol2qm74 1458 8 decrease decrease NN cord-015021-pol2qm74 1458 9 in in IN cord-015021-pol2qm74 1458 10 total total JJ cord-015021-pol2qm74 1458 11 protein protein NN cord-015021-pol2qm74 1458 12 pattern pattern NN cord-015021-pol2qm74 1458 13 ( ( -LRB- cord-015021-pol2qm74 1458 14 353 353 CD cord-015021-pol2qm74 1458 15 protein protein NN cord-015021-pol2qm74 1458 16 spots spot NNS cord-015021-pol2qm74 1458 17 vs vs IN cord-015021-pol2qm74 1458 18 503 503 CD cord-015021-pol2qm74 1458 19 protein protein NN cord-015021-pol2qm74 1458 20 spots spot NNS cord-015021-pol2qm74 1458 21 ) ) -RRB- cord-015021-pol2qm74 1458 22 when when WRB cord-015021-pol2qm74 1458 23 compared compare VBN cord-015021-pol2qm74 1458 24 to to IN cord-015021-pol2qm74 1458 25 non non JJ cord-015021-pol2qm74 1458 26 - - JJ cord-015021-pol2qm74 1458 27 septic septic JJ cord-015021-pol2qm74 1458 28 control control NN cord-015021-pol2qm74 1458 29 macrophages macrophage NNS cord-015021-pol2qm74 1458 30 . . . cord-015021-pol2qm74 1459 1 A a DT cord-015021-pol2qm74 1459 2 decrease decrease NN cord-015021-pol2qm74 1459 3 in in IN cord-015021-pol2qm74 1459 4 the the DT cord-015021-pol2qm74 1459 5 number number NN cord-015021-pol2qm74 1459 6 of of IN cord-015021-pol2qm74 1459 7 lower low JJR cord-015021-pol2qm74 1459 8 molecular molecular JJ cord-015021-pol2qm74 1459 9 weight weight NN cord-015021-pol2qm74 1459 10 proteins protein NNS cord-015021-pol2qm74 1459 11 ( ( -LRB- cord-015021-pol2qm74 1459 12 < < XX cord-015021-pol2qm74 1459 13 40 40 CD cord-015021-pol2qm74 1459 14 kD kd ADD cord-015021-pol2qm74 1459 15 ) ) -RRB- cord-015021-pol2qm74 1459 16 was be VBD cord-015021-pol2qm74 1459 17 observed observe VBN cord-015021-pol2qm74 1459 18 . . . cord-015021-pol2qm74 1460 1 At at IN cord-015021-pol2qm74 1460 2 24 24 CD cord-015021-pol2qm74 1460 3 hrs hrs NN cord-015021-pol2qm74 1460 4 . . . cord-015021-pol2qm74 1461 1 post post JJ cord-015021-pol2qm74 1461 2 - - JJ cord-015021-pol2qm74 1461 3 CLP clp JJ cord-015021-pol2qm74 1461 4 , , , cord-015021-pol2qm74 1461 5 splenic splenic JJ cord-015021-pol2qm74 1461 6 macrophages macrophage NNS cord-015021-pol2qm74 1461 7 from from IN cord-015021-pol2qm74 1461 8 CLP CLP NNP cord-015021-pol2qm74 1461 9 rats rat NNS cord-015021-pol2qm74 1461 10 showed show VBD cord-015021-pol2qm74 1461 11 a a DT cord-015021-pol2qm74 1461 12 substantial substantial JJ cord-015021-pol2qm74 1461 13 increase increase NN cord-015021-pol2qm74 1461 14 in in IN cord-015021-pol2qm74 1461 15 the the DT cord-015021-pol2qm74 1461 16 synthesis synthesis NN cord-015021-pol2qm74 1461 17 of of IN cord-015021-pol2qm74 1461 18 low low JJ cord-015021-pol2qm74 1461 19 molecular molecular JJ cord-015021-pol2qm74 1461 20 weight weight NN cord-015021-pol2qm74 1461 21 ( ( -LRB- cord-015021-pol2qm74 1461 22 < < XX cord-015021-pol2qm74 1461 23 40 40 CD cord-015021-pol2qm74 1461 24 kD kd JJ cord-015021-pol2qm74 1461 25 ) ) -RRB- cord-015021-pol2qm74 1461 26 proteins protein NNS cord-015021-pol2qm74 1461 27 , , , cord-015021-pol2qm74 1461 28 when when WRB cord-015021-pol2qm74 1461 29 compared compare VBN cord-015021-pol2qm74 1461 30 to to IN cord-015021-pol2qm74 1461 31 non non JJ cord-015021-pol2qm74 1461 32 - - JJ cord-015021-pol2qm74 1461 33 septic septic JJ cord-015021-pol2qm74 1461 34 controls control NNS cord-015021-pol2qm74 1461 35 . . . cord-015021-pol2qm74 1462 1 We -PRON- PRP cord-015021-pol2qm74 1462 2 conclude conclude VBP cord-015021-pol2qm74 1462 3 that that DT cord-015021-pol2qm74 1462 4 : : : cord-015021-pol2qm74 1462 5 l l LS cord-015021-pol2qm74 1462 6 ) ) -RRB- cord-015021-pol2qm74 1462 7 fulminate fulminate VBP cord-015021-pol2qm74 1462 8 abdominal abdominal JJ cord-015021-pol2qm74 1462 9 sepsis sepsis NN cord-015021-pol2qm74 1462 10 induces induce VBZ cord-015021-pol2qm74 1462 11 an an DT cord-015021-pol2qm74 1462 12 early early JJ cord-015021-pol2qm74 1462 13 ( ( -LRB- cord-015021-pol2qm74 1462 14 3 3 CD cord-015021-pol2qm74 1462 15 hrs hrs NN cord-015021-pol2qm74 1462 16 . . . cord-015021-pol2qm74 1462 17 ) ) -RRB- cord-015021-pol2qm74 1463 1 Staining stain VBG cord-015021-pol2qm74 1463 2 with with IN cord-015021-pol2qm74 1463 3 CD14 CD14 NNP cord-015021-pol2qm74 1463 4 and and CC cord-015021-pol2qm74 1463 5 CD16 CD16 NNP cord-015021-pol2qm74 1463 6 mAbs mAbs NNP cord-015021-pol2qm74 1463 7 will will MD cord-015021-pol2qm74 1463 8 identify identify VB cord-015021-pol2qm74 1463 9 two two CD cord-015021-pol2qm74 1463 10 monocyte monocyte NNP cord-015021-pol2qm74 1463 11 subpopulations subpopulation NNS cord-015021-pol2qm74 1463 12 in in IN cord-015021-pol2qm74 1463 13 human human JJ cord-015021-pol2qm74 1463 14 blood blood NN cord-015021-pol2qm74 1463 15 : : : cord-015021-pol2qm74 1463 16 A a DT cord-015021-pol2qm74 1463 17 major major JJ cord-015021-pol2qm74 1463 18 population population NN cord-015021-pol2qm74 1463 19 of of IN cord-015021-pol2qm74 1463 20 regular regular JJ cord-015021-pol2qm74 1463 21 monocytes monocyte NNS cord-015021-pol2qm74 1463 22 , , , cord-015021-pol2qm74 1463 23 which which WDT cord-015021-pol2qm74 1463 24 strongly strongly RB cord-015021-pol2qm74 1463 25 expresses express VBZ cord-015021-pol2qm74 1463 26 the the DT cord-015021-pol2qm74 1463 27 CD14 CD14 NNP cord-015021-pol2qm74 1463 28 antigen antigen NN cord-015021-pol2qm74 1463 29 ( ( -LRB- cord-015021-pol2qm74 1463 30 CD14++ cd14++ NN cord-015021-pol2qm74 1463 31 ) ) -RRB- cord-015021-pol2qm74 1463 32 and and CC cord-015021-pol2qm74 1463 33 a a DT cord-015021-pol2qm74 1463 34 minor minor JJ cord-015021-pol2qm74 1463 35 population population NN cord-015021-pol2qm74 1463 36 with with IN cord-015021-pol2qm74 1463 37 weak weak JJ cord-015021-pol2qm74 1463 38 expression expression NN cord-015021-pol2qm74 1463 39 of of IN cord-015021-pol2qm74 1463 40 CD14 CD14 NNP cord-015021-pol2qm74 1463 41 and and CC cord-015021-pol2qm74 1463 42 expression expression NN cord-015021-pol2qm74 1463 43 of of IN cord-015021-pol2qm74 1463 44 the the DT cord-015021-pol2qm74 1463 45 CD16 CD16 NNP cord-015021-pol2qm74 1463 46 antigen antigen NN cord-015021-pol2qm74 1463 47 lCD14+/ lCD14+/ NNS cord-015021-pol2qm74 1464 1 CD16 CD16 NNP cord-015021-pol2qm74 1464 2 + + CC cord-015021-pol2qm74 1464 3 cells cell NNS cord-015021-pol2qm74 1464 4 ) ) -RRB- cord-015021-pol2qm74 1464 5 . . . cord-015021-pol2qm74 1465 1 In in IN cord-015021-pol2qm74 1465 2 healthy healthy JJ cord-015021-pol2qm74 1465 3 control control NN cord-015021-pol2qm74 1465 4 donors(n=35 donors(n=35 IN cord-015021-pol2qm74 1465 5 ) ) -RRB- cord-015021-pol2qm74 1465 6 the the DT cord-015021-pol2qm74 1465 7 latter latter JJ cord-015021-pol2qm74 1465 8 cells cell NNS cord-015021-pol2qm74 1465 9 account account VBP cord-015021-pol2qm74 1465 10 for for IN cord-015021-pol2qm74 1465 11 45 45 CD cord-015021-pol2qm74 1465 12 + + SYM cord-015021-pol2qm74 1465 13 22 22 CD cord-015021-pol2qm74 1465 14 cells cell NNS cord-015021-pol2qm74 1465 15 / / SYM cord-015021-pol2qm74 1465 16 mm mm NNP cord-015021-pol2qm74 1465 17 3 3 CD cord-015021-pol2qm74 1465 18 and and CC cord-015021-pol2qm74 1465 19 9%+5 9%+5 CD cord-015021-pol2qm74 1465 20 % % NN cord-015021-pol2qm74 1465 21 of of IN cord-015021-pol2qm74 1465 22 the the DT cord-015021-pol2qm74 1465 23 monocytes monocyte NNS cord-015021-pol2qm74 1465 24 . . . cord-015021-pol2qm74 1466 1 In in IN cord-015021-pol2qm74 1466 2 sepsis sepsis NN cord-015021-pol2qm74 1466 3 patients patient NNS cord-015021-pol2qm74 1466 4 , , , cord-015021-pol2qm74 1466 5 the the DT cord-015021-pol2qm74 1466 6 CD]4+/CD16 cd]4+/cd16 NN cord-015021-pol2qm74 1466 7 + + CC cord-015021-pol2qm74 1466 8 cells cell NNS cord-015021-pol2qm74 1466 9 can can MD cord-015021-pol2qm74 1466 10 become become VB cord-015021-pol2qm74 1466 11 a a DT cord-015021-pol2qm74 1466 12 major major JJ cord-015021-pol2qm74 1466 13 population population NN cord-015021-pol2qm74 1466 14 with with IN cord-015021-pol2qm74 1466 15 more more JJR cord-015021-pol2qm74 1466 16 than than IN cord-015021-pol2qm74 1466 17 50 50 CD cord-015021-pol2qm74 1466 18 % % NN cord-015021-pol2qm74 1466 19 of of IN cord-015021-pol2qm74 1466 20 all all DT cord-015021-pol2qm74 1466 21 monocytes monocyte NNS cord-015021-pol2qm74 1466 22 in in IN cord-015021-pol2qm74 1466 23 3 3 CD cord-015021-pol2qm74 1466 24 of of IN cord-015021-pol2qm74 1466 25 18 18 CD cord-015021-pol2qm74 1466 26 patients patient NNS cord-015021-pol2qm74 1466 27 and and CC cord-015021-pol2qm74 1466 28 with with IN cord-015021-pol2qm74 1466 29 more more JJR cord-015021-pol2qm74 1466 30 than than IN cord-015021-pol2qm74 1466 31 500 500 CD cord-015021-pol2qm74 1466 32 cells cell NNS cord-015021-pol2qm74 1466 33 / / SYM cord-015021-pol2qm74 1466 34 mm mm NN cord-015021-pol2qm74 1466 35 3 3 CD cord-015021-pol2qm74 1466 36 in in IN cord-015021-pol2qm74 1466 37 4 4 CD cord-015021-pol2qm74 1466 38 of of IN cord-015021-pol2qm74 1466 39 18 18 CD cord-015021-pol2qm74 1466 40 cases case NNS cord-015021-pol2qm74 1466 41 . . . cord-015021-pol2qm74 1467 1 There there EX cord-015021-pol2qm74 1467 2 was be VBD cord-015021-pol2qm74 1467 3 no no DT cord-015021-pol2qm74 1467 4 correlation correlation NN cord-015021-pol2qm74 1467 5 of of IN cord-015021-pol2qm74 1467 6 CD14+/ cd14+/ NN cord-015021-pol2qm74 1468 1 CD16 CD16 NNP cord-015021-pol2qm74 1468 2 + + CC cord-015021-pol2qm74 1468 3 cells cell NNS cord-015021-pol2qm74 1468 4 to to IN cord-015021-pol2qm74 1468 5 any any DT cord-015021-pol2qm74 1468 6 clinical clinical JJ cord-015021-pol2qm74 1468 7 parameter parameter NN cord-015021-pol2qm74 1468 8 except except IN cord-015021-pol2qm74 1468 9 for for IN cord-015021-pol2qm74 1468 10 CD14+/CD16 cd14+/cd16 NN cord-015021-pol2qm74 1468 11 + + CC cord-015021-pol2qm74 1468 12 percentage percentage NN cord-015021-pol2qm74 1468 13 and and CC cord-015021-pol2qm74 1468 14 body body NN cord-015021-pol2qm74 1468 15 temperature temperature NN cord-015021-pol2qm74 1468 16 ( ( -LRB- cord-015021-pol2qm74 1468 17 p= p= NNP cord-015021-pol2qm74 1468 18 0.013 0.013 CD cord-015021-pol2qm74 1468 19 ) ) -RRB- cord-015021-pol2qm74 1468 20 . . . cord-015021-pol2qm74 1469 1 The the DT cord-015021-pol2qm74 1469 2 CD14++ cd14++ CD cord-015021-pol2qm74 1469 3 monocytes monocyte NNS cord-015021-pol2qm74 1469 4 showed show VBD cord-015021-pol2qm74 1469 5 a a DT cord-015021-pol2qm74 1469 6 substanttial substanttial JJ cord-015021-pol2qm74 1469 7 decrease decrease NN cord-015021-pol2qm74 1469 8 in in IN cord-015021-pol2qm74 1469 9 CD14 CD14 NNP cord-015021-pol2qm74 1469 10 antigen antigen NN cord-015021-pol2qm74 1469 11 density density NN cord-015021-pol2qm74 1469 12 in in IN cord-015021-pol2qm74 1469 13 9 9 CD cord-015021-pol2qm74 1469 14 of of IN cord-015021-pol2qm74 1469 15 11 11 CD cord-015021-pol2qm74 1469 16 patients patient NNS cord-015021-pol2qm74 1469 17 . . . cord-015021-pol2qm74 1470 1 Three three CD cord-015021-pol2qm74 1470 2 - - HYPH cord-015021-pol2qm74 1470 3 color color NN cord-015021-pol2qm74 1470 4 - - HYPH cord-015021-pol2qm74 1470 5 IF if NN cord-015021-pol2qm74 1470 6 shows show VBZ cord-015021-pol2qm74 1470 7 that that IN cord-015021-pol2qm74 1470 8 the the DT cord-015021-pol2qm74 1470 9 CD14+/ CD14+/ NNP cord-015021-pol2qm74 1470 10 CD16 CD16 NNP cord-015021-pol2qm74 1470 11 + + CC cord-015021-pol2qm74 1470 12 cells cell NNS cord-015021-pol2qm74 1470 13 in in IN cord-015021-pol2qm74 1470 14 sepsis sepsis NN cord-015021-pol2qm74 1470 15 patients patient NNS cord-015021-pol2qm74 1470 16 when when WRB cord-015021-pol2qm74 1470 17 compared compare VBN cord-015021-pol2qm74 1470 18 with with IN cord-015021-pol2qm74 1471 1 the the DT cord-015021-pol2qm74 1471 2 CD14++ cd14++ CD cord-015021-pol2qm74 1471 3 monocytes monocyte VBZ cord-015021-pol2qm74 1471 4 exhibit exhibit VBP cord-015021-pol2qm74 1471 5 a a DT cord-015021-pol2qm74 1471 6 higher high JJR cord-015021-pol2qm74 1471 7 level level NN cord-015021-pol2qm74 1471 8 of of IN cord-015021-pol2qm74 1471 9 class class NN cord-015021-pol2qm74 1471 10 II II NNP cord-015021-pol2qm74 1471 11 antigen antigen NN cord-015021-pol2qm74 1471 12 and and CC cord-015021-pol2qm74 1471 13 a a DT cord-015021-pol2qm74 1471 14 lower low JJR cord-015021-pol2qm74 1471 15 level level NN cord-015021-pol2qm74 1471 16 of of IN cord-015021-pol2qm74 1471 17 CDIIb CDIIb NNS cord-015021-pol2qm74 1471 18 and and CC cord-015021-pol2qm74 1471 19 CD33 CD33 NNP cord-015021-pol2qm74 1471 20 antigens antigen NNS cord-015021-pol2qm74 1471 21 , , , cord-015021-pol2qm74 1471 22 consistent consistent JJ cord-015021-pol2qm74 1471 23 with with IN cord-015021-pol2qm74 1471 24 a a DT cord-015021-pol2qm74 1471 25 more more RBR cord-015021-pol2qm74 1471 26 mature mature JJ cord-015021-pol2qm74 1471 27 nature nature NN cord-015021-pol2qm74 1471 28 of of IN cord-015021-pol2qm74 1471 29 the the DT cord-015021-pol2qm74 1471 30 CD14+/CD16 cd14+/cd16 NN cord-015021-pol2qm74 1471 31 + + SYM cord-015021-pol2qm74 1471 32 cells cell NNS cord-015021-pol2qm74 1471 33 . . . cord-015021-pol2qm74 1472 1 Levels level NNS cord-015021-pol2qm74 1472 2 of of IN cord-015021-pol2qm74 1472 3 IL-6 IL-6 NNP cord-015021-pol2qm74 1472 4 were be VBD cord-015021-pol2qm74 1472 5 increased increase VBN cord-015021-pol2qm74 1472 6 in in IN cord-015021-pol2qm74 1472 7 sepsis sepsis NN cord-015021-pol2qm74 1472 8 patients patient NNS cord-015021-pol2qm74 1472 9 : : : cord-015021-pol2qm74 1472 10 3 3 CD cord-015021-pol2qm74 1472 11 of of IN cord-015021-pol2qm74 1472 12 5 5 CD cord-015021-pol2qm74 1472 13 patients patient NNS cord-015021-pol2qm74 1472 14 with with IN cord-015021-pol2qm74 1472 15 high high JJ cord-015021-pol2qm74 1472 16 numbers number NNS cord-015021-pol2qm74 1472 17 of of IN cord-015021-pol2qm74 1472 18 CDI4+/CD16 cdi4+/cd16 NN cord-015021-pol2qm74 1472 19 + + CC cord-015021-pol2qm74 1472 20 cells cell NNS cord-015021-pol2qm74 1472 21 ( ( -LRB- cord-015021-pol2qm74 1472 22 200 200 CD cord-015021-pol2qm74 1472 23 / / SYM cord-015021-pol2qm74 1472 24 mm mm NN cord-015021-pol2qm74 1472 25 3 3 CD cord-015021-pol2qm74 1472 26 ) ) -RRB- cord-015021-pol2qm74 1472 27 had have VBD cord-015021-pol2qm74 1472 28 high high JJ cord-015021-pol2qm74 1472 29 levels level NNS cord-015021-pol2qm74 1472 30 of of IN cord-015021-pol2qm74 1472 31 IL-6 IL-6 NNP cord-015021-pol2qm74 1472 32 ( ( -LRB- cord-015021-pol2qm74 1472 33 250U 250u CD cord-015021-pol2qm74 1472 34 / / SYM cord-015021-pol2qm74 1472 35 ml ml NN cord-015021-pol2qm74 1472 36 ) ) -RRB- cord-015021-pol2qm74 1472 37 . . . cord-015021-pol2qm74 1473 1 These these DT cord-015021-pol2qm74 1473 2 data datum NNS cord-015021-pol2qm74 1473 3 suggest suggest VBP cord-015021-pol2qm74 1473 4 that that IN cord-015021-pol2qm74 1473 5 septicemia septicemia NN cord-015021-pol2qm74 1473 6 may may MD cord-015021-pol2qm74 1473 7 lead lead VB cord-015021-pol2qm74 1473 8 to to IN cord-015021-pol2qm74 1473 9 substantial substantial JJ cord-015021-pol2qm74 1473 10 changes change NNS cord-015021-pol2qm74 1473 11 in in IN cord-015021-pol2qm74 1473 12 blood blood NN cord-015021-pol2qm74 1473 13 monocyte monocyte NNP cord-015021-pol2qm74 1473 14 composition composition NN cord-015021-pol2qm74 1473 15 and and CC cord-015021-pol2qm74 1473 16 this this DT cord-015021-pol2qm74 1473 17 may may MD cord-015021-pol2qm74 1473 18 be be VB cord-015021-pol2qm74 1473 19 related relate VBN cord-015021-pol2qm74 1473 20 to to IN cord-015021-pol2qm74 1473 21 elevated elevated JJ cord-015021-pol2qm74 1473 22 levels level NNS cord-015021-pol2qm74 1473 23 of of IN cord-015021-pol2qm74 1473 24 cytokines cytokine NNS cord-015021-pol2qm74 1473 25 such such JJ cord-015021-pol2qm74 1473 26 as as IN cord-015021-pol2qm74 1473 27 IL-6 IL-6 NNP cord-015021-pol2qm74 1473 28 . . . cord-015021-pol2qm74 1474 1 Human human JJ cord-015021-pol2qm74 1474 2 peritoneal peritoneal JJ cord-015021-pol2qm74 1474 3 macrophages macrophage NNS cord-015021-pol2qm74 1474 4 were be VBD cord-015021-pol2qm74 1474 5 exposed expose VBN cord-015021-pol2qm74 1474 6 to to IN cord-015021-pol2qm74 1474 7 increasing increase VBG cord-015021-pol2qm74 1474 8 doses dose NNS cord-015021-pol2qm74 1474 9 of of IN cord-015021-pol2qm74 1474 10 Lipopolysaccharide Lipopolysaccharide NNP cord-015021-pol2qm74 1474 11 ( ( -LRB- cord-015021-pol2qm74 1474 12 LPS LPS NNP cord-015021-pol2qm74 1474 13 ) ) -RRB- cord-015021-pol2qm74 1474 14 or or CC cord-015021-pol2qm74 1474 15 a a DT cord-015021-pol2qm74 1474 16 synthetic synthetic JJ cord-015021-pol2qm74 1474 17 Lipid Lipid NNP cord-015021-pol2qm74 1474 18 A a DT cord-015021-pol2qm74 1474 19 analogue analogue NN cord-015021-pol2qm74 1474 20 ( ( -LRB- cord-015021-pol2qm74 1474 21 MRL MRL NNP cord-015021-pol2qm74 1474 22 953 953 CD cord-015021-pol2qm74 1474 23 ) ) -RRB- cord-015021-pol2qm74 1474 24 and and CC cord-015021-pol2qm74 1474 25 production production NN cord-015021-pol2qm74 1474 26 of of IN cord-015021-pol2qm74 1474 27 the the DT cord-015021-pol2qm74 1474 28 cytokines cytokine NNS cord-015021-pol2qm74 1474 29 IL IL NNP cord-015021-pol2qm74 1474 30 - - HYPH cord-015021-pol2qm74 1474 31 lb lb NNP cord-015021-pol2qm74 1474 32 , , , cord-015021-pol2qm74 1474 33 iL-6 iL-6 NNP cord-015021-pol2qm74 1474 34 , , , cord-015021-pol2qm74 1474 35 TNF TNF NNP cord-015021-pol2qm74 1474 36 - - : cord-015021-pol2qm74 1474 37 a a NNP cord-015021-pol2qm74 1474 38 and and CC cord-015021-pol2qm74 1474 39 G G NNP cord-015021-pol2qm74 1474 40 - - HYPH cord-015021-pol2qm74 1474 41 CSF CSF NNP cord-015021-pol2qm74 1474 42 was be VBD cord-015021-pol2qm74 1474 43 assessed assess VBN cord-015021-pol2qm74 1474 44 at at IN cord-015021-pol2qm74 1474 45 the the DT cord-015021-pol2qm74 1474 46 protein protein NN cord-015021-pol2qm74 1474 47 - - : cord-015021-pol2qm74 1474 48 and and CC cord-015021-pol2qm74 1474 49 mRNAlevel mRNAlevel NNS cord-015021-pol2qm74 1474 50 . . . cord-015021-pol2qm74 1475 1 Cells cell NNS cord-015021-pol2qm74 1475 2 were be VBD cord-015021-pol2qm74 1475 3 also also RB cord-015021-pol2qm74 1475 4 stimulated stimulate VBN cord-015021-pol2qm74 1475 5 with with IN cord-015021-pol2qm74 1475 6 low low JJ cord-015021-pol2qm74 1475 7 doses dose NNS cord-015021-pol2qm74 1475 8 of of IN cord-015021-pol2qm74 1475 9 LPS LPS NNP cord-015021-pol2qm74 1475 10 and and CC cord-015021-pol2qm74 1475 11 MRL MRL NNP cord-015021-pol2qm74 1475 12 953 953 CD cord-015021-pol2qm74 1475 13 to to TO cord-015021-pol2qm74 1475 14 study study VB cord-015021-pol2qm74 1475 15 their -PRON- PRP$ cord-015021-pol2qm74 1475 16 " " `` cord-015021-pol2qm74 1475 17 adaptation adaptation NN cord-015021-pol2qm74 1475 18 " " '' cord-015021-pol2qm74 1475 19 to to IN cord-015021-pol2qm74 1475 20 a a DT cord-015021-pol2qm74 1475 21 secondary secondary JJ cord-015021-pol2qm74 1475 22 challenge challenge NN cord-015021-pol2qm74 1475 23 with with IN cord-015021-pol2qm74 1475 24 high high JJ cord-015021-pol2qm74 1475 25 doses dose NNS cord-015021-pol2qm74 1475 26 of of IN cord-015021-pol2qm74 1475 27 LPS lp NNS cord-015021-pol2qm74 1475 28 . . . cord-015021-pol2qm74 1476 1 TNF TNF NNP cord-015021-pol2qm74 1476 2 - - : cord-015021-pol2qm74 1476 3 a a DT cord-015021-pol2qm74 1476 4 production production NN cord-015021-pol2qm74 1476 5 after after IN cord-015021-pol2qm74 1476 6 stimulation stimulation NN cord-015021-pol2qm74 1476 7 with with IN cord-015021-pol2qm74 1476 8 LPS LPS NNP cord-015021-pol2qm74 1476 9 could could MD cord-015021-pol2qm74 1476 10 be be VB cord-015021-pol2qm74 1476 11 almost almost RB cord-015021-pol2qm74 1476 12 completely completely RB cord-015021-pol2qm74 1476 13 relieved relieve VBN cord-015021-pol2qm74 1476 14 by by IN cord-015021-pol2qm74 1476 15 preincubation preincubation NN cord-015021-pol2qm74 1476 16 of of IN cord-015021-pol2qm74 1476 17 cells cell NNS cord-015021-pol2qm74 1476 18 with with IN cord-015021-pol2qm74 1476 19 low low JJ cord-015021-pol2qm74 1476 20 doses dose NNS cord-015021-pol2qm74 1476 21 of of IN cord-015021-pol2qm74 1476 22 LPS LPS NNP cord-015021-pol2qm74 1476 23 and and CC cord-015021-pol2qm74 1476 24 similarly similarly RB cord-015021-pol2qm74 1476 25 , , , cord-015021-pol2qm74 1476 26 IL-6 IL-6 NNP cord-015021-pol2qm74 1476 27 production production NN cord-015021-pol2qm74 1476 28 was be VBD cord-015021-pol2qm74 1476 29 suppressed suppress VBN cord-015021-pol2qm74 1476 30 . . . cord-015021-pol2qm74 1477 1 Surprisingly surprisingly RB cord-015021-pol2qm74 1477 2 , , , cord-015021-pol2qm74 1477 3 however however RB cord-015021-pol2qm74 1477 4 , , , cord-015021-pol2qm74 1477 5 " " `` cord-015021-pol2qm74 1477 6 adapted adapt VBN cord-015021-pol2qm74 1477 7 " " '' cord-015021-pol2qm74 1477 8 cells cell NNS cord-015021-pol2qm74 1477 9 were be VBD cord-015021-pol2qm74 1477 10 able able JJ cord-015021-pol2qm74 1477 11 to to TO cord-015021-pol2qm74 1477 12 synthesize synthesize VB cord-015021-pol2qm74 1477 13 even even RB cord-015021-pol2qm74 1477 14 larger large JJR cord-015021-pol2qm74 1477 15 quantities quantity NNS cord-015021-pol2qm74 1477 16 of of IN cord-015021-pol2qm74 1477 17 of of IN cord-015021-pol2qm74 1477 18 G G NNP cord-015021-pol2qm74 1477 19 - - HYPH cord-015021-pol2qm74 1477 20 CSF CSF NNP cord-015021-pol2qm74 1477 21 and and CC cord-015021-pol2qm74 1477 22 IL IL NNP cord-015021-pol2qm74 1477 23 - - HYPH cord-015021-pol2qm74 1477 24 lb lb NNP cord-015021-pol2qm74 1477 25 when when WRB cord-015021-pol2qm74 1477 26 exposed expose VBN cord-015021-pol2qm74 1477 27 to to IN cord-015021-pol2qm74 1477 28 a a DT cord-015021-pol2qm74 1477 29 secondary secondary JJ cord-015021-pol2qm74 1477 30 LPS LPS NNP cord-015021-pol2qm74 1477 31 challenge challenge NN cord-015021-pol2qm74 1477 32 . . . cord-015021-pol2qm74 1478 1 The the DT cord-015021-pol2qm74 1478 2 changes change NNS cord-015021-pol2qm74 1478 3 in in IN cord-015021-pol2qm74 1478 4 TNF TNF NNP cord-015021-pol2qm74 1478 5 - - HYPH cord-015021-pol2qm74 1478 6 a a NNP cord-015021-pol2qm74 1478 7 , , , cord-015021-pol2qm74 1478 8 IL-6 IL-6 NNP cord-015021-pol2qm74 1478 9 and and CC cord-015021-pol2qm74 1478 10 G G NNP cord-015021-pol2qm74 1478 11 - - HYPH cord-015021-pol2qm74 1478 12 CSF CSF NNP cord-015021-pol2qm74 1478 13 protein protein NN cord-015021-pol2qm74 1478 14 synthesis synthesis NN cord-015021-pol2qm74 1478 15 could could MD cord-015021-pol2qm74 1478 16 a a DT cord-015021-pol2qm74 1478 17 / / SYM cord-015021-pol2qm74 1478 18 so so RB cord-015021-pol2qm74 1478 19 be be VB cord-015021-pol2qm74 1478 20 detected detect VBN cord-015021-pol2qm74 1478 21 on on IN cord-015021-pol2qm74 1478 22 the the DT cord-015021-pol2qm74 1478 23 mRNA mRNA NNP cord-015021-pol2qm74 1478 24 level level NN cord-015021-pol2qm74 1478 25 , , , cord-015021-pol2qm74 1478 26 whereas whereas IN cord-015021-pol2qm74 1478 27 transcript transcript NN cord-015021-pol2qm74 1478 28 levels level NNS cord-015021-pol2qm74 1478 29 for for IN cord-015021-pol2qm74 1478 30 IL IL NNP cord-015021-pol2qm74 1478 31 - - HYPH cord-015021-pol2qm74 1478 32 lb lb NN cord-015021-pol2qm74 1478 33 remained remain VBD cord-015021-pol2qm74 1478 34 unaltered unaltered JJ cord-015021-pol2qm74 1478 35 as as IN cord-015021-pol2qm74 1478 36 assessed assess VBN cord-015021-pol2qm74 1478 37 by by IN cord-015021-pol2qm74 1478 38 Northern northern JJ cord-015021-pol2qm74 1478 39 blot blot NN cord-015021-pol2qm74 1478 40 analysis analysis NN cord-015021-pol2qm74 1478 41 . . . cord-015021-pol2qm74 1479 1 High high JJ cord-015021-pol2qm74 1479 2 doses dose NNS cord-015021-pol2qm74 1479 3 of of IN cord-015021-pol2qm74 1479 4 the the DT cord-015021-pol2qm74 1479 5 synthetic synthetic JJ cord-015021-pol2qm74 1479 6 lipid lipid NN cord-015021-pol2qm74 1480 1 A a DT cord-015021-pol2qm74 1480 2 analogue analogue NN cord-015021-pol2qm74 1480 3 MRL MRL NNP cord-015021-pol2qm74 1480 4 953 953 CD cord-015021-pol2qm74 1480 5 were be VBD cord-015021-pol2qm74 1480 6 also also RB cord-015021-pol2qm74 1480 7 able able JJ cord-015021-pol2qm74 1480 8 to to TO cord-015021-pol2qm74 1480 9 " " `` cord-015021-pol2qm74 1480 10 adapt adapt VB cord-015021-pol2qm74 1480 11 " " '' cord-015021-pol2qm74 1480 12 macrophages macrophage NNS cord-015021-pol2qm74 1480 13 for for IN cord-015021-pol2qm74 1480 14 a a DT cord-015021-pol2qm74 1480 15 secondary secondary JJ cord-015021-pol2qm74 1480 16 LPS LPS NNP cord-015021-pol2qm74 1480 17 challenge challenge NN cord-015021-pol2qm74 1480 18 by by IN cord-015021-pol2qm74 1480 19 downregulating downregulate VBG cord-015021-pol2qm74 1480 20 TNFa TNFa NNP cord-015021-pol2qm74 1480 21 - - : cord-015021-pol2qm74 1480 22 and and CC cord-015021-pol2qm74 1480 23 IL-6-production il-6-production NN cord-015021-pol2qm74 1480 24 , , , cord-015021-pol2qm74 1480 25 while while IN cord-015021-pol2qm74 1480 26 priming prime VBG cord-015021-pol2qm74 1480 27 secretion secretion NN cord-015021-pol2qm74 1480 28 of of IN cord-015021-pol2qm74 1480 29 G G NNP cord-015021-pol2qm74 1480 30 - - HYPH cord-015021-pol2qm74 1480 31 CSFand CSFand NNP cord-015021-pol2qm74 1480 32 IL IL NNP cord-015021-pol2qm74 1480 33 - - HYPH cord-015021-pol2qm74 1480 34 lb lb NNP cord-015021-pol2qm74 1480 35 as as RB cord-015021-pol2qm74 1480 36 well well RB cord-015021-pol2qm74 1480 37 . . . cord-015021-pol2qm74 1481 1 Taken take VBN cord-015021-pol2qm74 1481 2 together together RB cord-015021-pol2qm74 1481 3 , , , cord-015021-pol2qm74 1481 4 here here RB cord-015021-pol2qm74 1481 5 we -PRON- PRP cord-015021-pol2qm74 1481 6 describe describe VBP cord-015021-pol2qm74 1481 7 for for IN cord-015021-pol2qm74 1481 8 the the DT cord-015021-pol2qm74 1481 9 first first JJ cord-015021-pol2qm74 1481 10 time time NN cord-015021-pol2qm74 1481 11 the the DT cord-015021-pol2qm74 1481 12 discordant discordant JJ cord-015021-pol2qm74 1481 13 adaptation adaptation NN cord-015021-pol2qm74 1481 14 of of IN cord-015021-pol2qm74 1481 15 human human JJ cord-015021-pol2qm74 1481 16 peritoneal peritoneal JJ cord-015021-pol2qm74 1481 17 macrophages macrophage NNS cord-015021-pol2qm74 1481 18 to to IN cord-015021-pol2qm74 1481 19 a a DT cord-015021-pol2qm74 1481 20 secondary secondary JJ cord-015021-pol2qm74 1481 21 LPS LPS NNP cord-015021-pol2qm74 1481 22 stimulus stimulus NN cord-015021-pol2qm74 1481 23 in in IN cord-015021-pol2qm74 1481 24 vitro vitro FW cord-015021-pol2qm74 1481 25 . . . cord-015021-pol2qm74 1482 1 These these DT cord-015021-pol2qm74 1482 2 findings finding NNS cord-015021-pol2qm74 1482 3 appear appear VBP cord-015021-pol2qm74 1482 4 to to TO cord-015021-pol2qm74 1482 5 bear bear VB cord-015021-pol2qm74 1482 6 ramifications ramification NNS cord-015021-pol2qm74 1482 7 for for IN cord-015021-pol2qm74 1482 8 the the DT cord-015021-pol2qm74 1482 9 in in IN cord-015021-pol2qm74 1482 10 - - HYPH cord-015021-pol2qm74 1482 11 vivo vivo NN cord-015021-pol2qm74 1482 12 endotoxin endotoxin NN cord-015021-pol2qm74 1482 13 response response NN cord-015021-pol2qm74 1482 14 during during IN cord-015021-pol2qm74 1482 15 inflammation inflammation NN cord-015021-pol2qm74 1482 16 and and CC cord-015021-pol2qm74 1482 17 gramnegative gramnegative NN cord-015021-pol2qm74 1482 18 septicemia septicemia NN cord-015021-pol2qm74 1482 19 . . . cord-015021-pol2qm74 1483 1 Shock shock NN cord-015021-pol2qm74 1483 2 states state NNS cord-015021-pol2qm74 1483 3 with with IN cord-015021-pol2qm74 1483 4 inadequate inadequate JJ cord-015021-pol2qm74 1483 5 cellular cellular JJ cord-015021-pol2qm74 1483 6 oxygen oxygen NN cord-015021-pol2qm74 1483 7 delivery delivery NN cord-015021-pol2qm74 1483 8 may may MD cord-015021-pol2qm74 1483 9 contribute contribute VB cord-015021-pol2qm74 1483 10 to to IN cord-015021-pol2qm74 1483 11 macrophage macrophage NN cord-015021-pol2qm74 1483 12 ( ( -LRB- cord-015021-pol2qm74 1483 13 MO MO NNP cord-015021-pol2qm74 1483 14 ) ) -RRB- cord-015021-pol2qm74 1483 15 activation activation NN cord-015021-pol2qm74 1483 16 or or CC cord-015021-pol2qm74 1483 17 dysregulation dysregulation NN cord-015021-pol2qm74 1483 18 . . . cord-015021-pol2qm74 1484 1 In in IN cord-015021-pol2qm74 1484 2 this this DT cord-015021-pol2qm74 1484 3 study study NN cord-015021-pol2qm74 1484 4 we -PRON- PRP cord-015021-pol2qm74 1484 5 compared compare VBD cord-015021-pol2qm74 1484 6 the the DT cord-015021-pol2qm74 1484 7 effect effect NN cord-015021-pol2qm74 1484 8 of of IN cord-015021-pol2qm74 1484 9 transient transient JJ cord-015021-pol2qm74 1484 10 hypoxia hypoxia NN cord-015021-pol2qm74 1484 11 and and CC cord-015021-pol2qm74 1484 12 endotoxin endotoxin NN cord-015021-pol2qm74 1484 13 pretreatment pretreatment NN cord-015021-pol2qm74 1484 14 ( ( -LRB- cord-015021-pol2qm74 1484 15 LPS LPS NNP cord-015021-pol2qm74 1484 16 1 1 CD cord-015021-pol2qm74 1484 17 ) ) -RRB- cord-015021-pol2qm74 1484 18 on on IN cord-015021-pol2qm74 1484 19 MO MO NNP cord-015021-pol2qm74 1484 20 mediator mediator NN cord-015021-pol2qm74 1484 21 release release NN cord-015021-pol2qm74 1484 22 with with IN cord-015021-pol2qm74 1484 23 a a DT cord-015021-pol2qm74 1484 24 second second JJ cord-015021-pol2qm74 1484 25 endotoxin endotoxin NN cord-015021-pol2qm74 1484 26 stimulus stimulus NN cord-015021-pol2qm74 1484 27 ( ( -LRB- cord-015021-pol2qm74 1484 28 LPS2 LPS2 NNP cord-015021-pol2qm74 1484 29 ) ) -RRB- cord-015021-pol2qm74 1484 30 . . . cord-015021-pol2qm74 1485 1 Methods method NNS cord-015021-pol2qm74 1485 2 : : : cord-015021-pol2qm74 1486 1 In in IN cord-015021-pol2qm74 1486 2 vitro vitro FW cord-015021-pol2qm74 1486 3 cultures culture NNS cord-015021-pol2qm74 1486 4 of of IN cord-015021-pol2qm74 1486 5 marine marine JJ cord-015021-pol2qm74 1486 6 peritoneal peritoneal NN cord-015021-pol2qm74 1486 7 exudate exudate NNP cord-015021-pol2qm74 1486 8 MO MO NNP cord-015021-pol2qm74 1486 9 were be VBD cord-015021-pol2qm74 1486 10 exposed expose VBN cord-015021-pol2qm74 1486 11 to to IN cord-015021-pol2qm74 1486 12 2 2 CD cord-015021-pol2qm74 1486 13 hr hr NN cord-015021-pol2qm74 1486 14 . . . cord-015021-pol2qm74 1487 1 of of IN cord-015021-pol2qm74 1487 2 hypoxic hypoxic JJ cord-015021-pol2qm74 1487 3 or or CC cord-015021-pol2qm74 1487 4 normoxic normoxic JJ cord-015021-pol2qm74 1487 5 conditions condition NNS cord-015021-pol2qm74 1487 6 , , , cord-015021-pol2qm74 1487 7 then then RB cord-015021-pol2qm74 1487 8 incubated incubate VBD cord-015021-pol2qm74 1487 9 22 22 CD cord-015021-pol2qm74 1487 10 hr hr NN cord-015021-pol2qm74 1487 11 under under IN cord-015021-pol2qm74 1487 12 identical identical JJ cord-015021-pol2qm74 1487 13 normoxic normoxic JJ cord-015021-pol2qm74 1487 14 conditions condition NNS cord-015021-pol2qm74 1487 15 _ _ NNP cord-015021-pol2qm74 1488 1 + + SYM cord-015021-pol2qm74 1488 2 10 10 CD cord-015021-pol2qm74 1488 3 ng ng NN cord-015021-pol2qm74 1488 4 / / SYM cord-015021-pol2qm74 1488 5 ml ml NNS cord-015021-pol2qm74 1488 6 of of IN cord-015021-pol2qm74 1488 7 LPS LPS NNP cord-015021-pol2qm74 1488 8 1 1 CD cord-015021-pol2qm74 1488 9 pretreatment pretreatment NN cord-015021-pol2qm74 1488 10 . . . cord-015021-pol2qm74 1489 1 During during IN cord-015021-pol2qm74 1489 2 the the DT cord-015021-pol2qm74 1489 3 final final JJ cord-015021-pol2qm74 1489 4 24 24 CD cord-015021-pol2qm74 1489 5 hours hour NNS cord-015021-pol2qm74 1489 6 all all DT cord-015021-pol2qm74 1489 7 M m NN cord-015021-pol2qm74 1490 1 ~l ~l NNP cord-015021-pol2qm74 1490 2 were be VBD cord-015021-pol2qm74 1490 3 exposed expose VBN cord-015021-pol2qm74 1490 4 to to IN cord-015021-pol2qm74 1490 5 a a DT cord-015021-pol2qm74 1490 6 range range NN cord-015021-pol2qm74 1490 7 of of IN cord-015021-pol2qm74 1490 8 LPS LPS NNP cord-015021-pol2qm74 1490 9 2 2 CD cord-015021-pol2qm74 1490 10 concentrations concentration NNS cord-015021-pol2qm74 1490 11 . . . cord-015021-pol2qm74 1491 1 M M NNP cord-015021-pol2qm74 1491 2 ~ ~ NFP cord-015021-pol2qm74 1491 3 i i PRP cord-015021-pol2qm74 1491 4 supernatants supernatant NNS cord-015021-pol2qm74 1491 5 were be VBD cord-015021-pol2qm74 1491 6 assayed assay VBN cord-015021-pol2qm74 1491 7 for for IN cord-015021-pol2qm74 1491 8 TNF TNF NNP cord-015021-pol2qm74 1491 9 , , , cord-015021-pol2qm74 1491 10 IL-1 IL-1 NNP cord-015021-pol2qm74 1491 11 , , , cord-015021-pol2qm74 1491 12 IL-6 IL-6 NNP cord-015021-pol2qm74 1491 13 , , , cord-015021-pol2qm74 1491 14 PGE2 PGE2 NNP cord-015021-pol2qm74 1491 15 , , , cord-015021-pol2qm74 1491 16 nitric nitric JJ cord-015021-pol2qm74 1491 17 oxide oxide NN cord-015021-pol2qm74 1491 18 ( ( -LRB- cord-015021-pol2qm74 1491 19 NO no UH cord-015021-pol2qm74 1491 20 ) ) -RRB- cord-015021-pol2qm74 1491 21 , , , cord-015021-pol2qm74 1491 22 and and CC cord-015021-pol2qm74 1491 23 superoxide superoxide NN cord-015021-pol2qm74 1491 24 release release NN cord-015021-pol2qm74 1491 25 . . . cord-015021-pol2qm74 1492 1 Results result NNS cord-015021-pol2qm74 1492 2 : : : cord-015021-pol2qm74 1493 1 LPS lp NNS cord-015021-pol2qm74 1493 2 1 1 CD cord-015021-pol2qm74 1493 3 markedly markedly RB cord-015021-pol2qm74 1493 4 inhibited inhibit VBN cord-015021-pol2qm74 1493 5 MO MO NNP cord-015021-pol2qm74 1493 6 TNF TNF NNP cord-015021-pol2qm74 1493 7 release release NN cord-015021-pol2qm74 1493 8 by by IN cord-015021-pol2qm74 1493 9 LPS LPS NNP cord-015021-pol2qm74 1493 10 2 2 CD cord-015021-pol2qm74 1493 11 but but CC cord-015021-pol2qm74 1493 12 hypoxia hypoxia NN cord-015021-pol2qm74 1493 13 had have VBD cord-015021-pol2qm74 1493 14 no no DT cord-015021-pol2qm74 1493 15 effect effect NN cord-015021-pol2qm74 1493 16 on on IN cord-015021-pol2qm74 1493 17 LPS LPS NNP cord-015021-pol2qm74 1493 18 2-triggered 2-triggered CD cord-015021-pol2qm74 1493 19 TNF TNF NNP cord-015021-pol2qm74 1493 20 release release NN cord-015021-pol2qm74 1493 21 . . . cord-015021-pol2qm74 1494 1 Hypoxia hypoxia NN cord-015021-pol2qm74 1494 2 increased increase VBD cord-015021-pol2qm74 1494 3 MO MO NNP cord-015021-pol2qm74 1494 4 IL-6 IL-6 NNP cord-015021-pol2qm74 1494 5 production production NN cord-015021-pol2qm74 1494 6 in in IN cord-015021-pol2qm74 1494 7 the the DT cord-015021-pol2qm74 1494 8 absence absence NN cord-015021-pol2qm74 1494 9 of of IN cord-015021-pol2qm74 1494 10 LPS LPS NNP cord-015021-pol2qm74 1494 11 1 1 CD cord-015021-pol2qm74 1494 12 , , , cord-015021-pol2qm74 1494 13 but but CC cord-015021-pol2qm74 1494 14 inhibited inhibited JJ cord-015021-pol2qm74 1494 15 LPS LPS NNP cord-015021-pol2qm74 1494 16 1 1 CD cord-015021-pol2qm74 1494 17 augmentation augmentation NN cord-015021-pol2qm74 1494 18 seen see VBN cord-015021-pol2qm74 1494 19 under under IN cord-015021-pol2qm74 1494 20 normoxic normoxic JJ cord-015021-pol2qm74 1494 21 conditions condition NNS cord-015021-pol2qm74 1494 22 . . . cord-015021-pol2qm74 1495 1 Pretreatment pretreatment NN cord-015021-pol2qm74 1495 2 with with IN cord-015021-pol2qm74 1495 3 LPS LPS NNP cord-015021-pol2qm74 1495 4 1 1 CD cord-015021-pol2qm74 1495 5 increased increase VBD cord-015021-pol2qm74 1495 6 NO no DT cord-015021-pol2qm74 1495 7 production production NN cord-015021-pol2qm74 1495 8 from from IN cord-015021-pol2qm74 1495 9 LPS LPS NNP cord-015021-pol2qm74 1495 10 2 2 CD cord-015021-pol2qm74 1495 11 under under IN cord-015021-pol2qm74 1495 12 normoxic normoxic JJ cord-015021-pol2qm74 1495 13 conditions condition NNS cord-015021-pol2qm74 1495 14 , , , cord-015021-pol2qm74 1495 15 but but CC cord-015021-pol2qm74 1495 16 bypoxiainhibited bypoxiainhibite VBD cord-015021-pol2qm74 1495 17 this this DT cord-015021-pol2qm74 1495 18 effect effect NN cord-015021-pol2qm74 1495 19 . . . cord-015021-pol2qm74 1496 1 Pretreatment pretreatment NN cord-015021-pol2qm74 1496 2 with with IN cord-015021-pol2qm74 1496 3 LPS1 LPS1 NNP cord-015021-pol2qm74 1496 4 signifcantly signifcantly RB cord-015021-pol2qm74 1496 5 augmented augment VBD cord-015021-pol2qm74 1496 6 MO MO NNP cord-015021-pol2qm74 1496 7 release release NN cord-015021-pol2qm74 1496 8 of of IN cord-015021-pol2qm74 1496 9 IL IL NNP cord-015021-pol2qm74 1496 10 - - HYPH cord-015021-pol2qm74 1496 11 i i NNP cord-015021-pol2qm74 1496 12 and and CC cord-015021-pol2qm74 1496 13 PGE PGE NNP cord-015021-pol2qm74 1496 14 2 2 CD cord-015021-pol2qm74 1496 15 , , , cord-015021-pol2qm74 1496 16 but but CC cord-015021-pol2qm74 1496 17 hypoxia hypoxia NN cord-015021-pol2qm74 1496 18 had have VBD cord-015021-pol2qm74 1496 19 no no DT cord-015021-pol2qm74 1496 20 significant significant JJ cord-015021-pol2qm74 1496 21 effect effect NN cord-015021-pol2qm74 1496 22 ( ( -LRB- cord-015021-pol2qm74 1496 23 data datum NNS cord-015021-pol2qm74 1496 24 not not RB cord-015021-pol2qm74 1496 25 shown show VBN cord-015021-pol2qm74 1496 26 ) ) -RRB- cord-015021-pol2qm74 1497 1 Superoxide superoxide NN cord-015021-pol2qm74 1497 2 production production NN cord-015021-pol2qm74 1497 3 was be VBD cord-015021-pol2qm74 1497 4 increased increase VBN cord-015021-pol2qm74 1497 5 by by IN cord-015021-pol2qm74 1497 6 LPS LPS NNP cord-015021-pol2qm74 1497 7 1 1 CD cord-015021-pol2qm74 1497 8 under under IN cord-015021-pol2qm74 1497 9 normoxic normoxic JJ cord-015021-pol2qm74 1497 10 conditions condition NNS cord-015021-pol2qm74 1497 11 , , , cord-015021-pol2qm74 1497 12 but but CC cord-015021-pol2qm74 1497 13 hypoxia hypoxia NN cord-015021-pol2qm74 1497 14 significantly significantly RB cord-015021-pol2qm74 1497 15 inhibited inhibit VBN cord-015021-pol2qm74 1497 16 superoxide superoxide NN cord-015021-pol2qm74 1497 17 release release NN cord-015021-pol2qm74 1497 18 ( ( -LRB- cord-015021-pol2qm74 1497 19 not not RB cord-015021-pol2qm74 1497 20 shown show VBN cord-015021-pol2qm74 1497 21 A. A. NNP cord-015021-pol2qm74 1497 22 Lepape Lepape NNP cord-015021-pol2qm74 1497 23 , , , cord-015021-pol2qm74 1497 24 C. C. NNP cord-015021-pol2qm74 1497 25 Docile Docile NNP cord-015021-pol2qm74 1497 26 , , , cord-015021-pol2qm74 1497 27 F. F. NNP cord-015021-pol2qm74 1497 28 Arpin Arpin NNP cord-015021-pol2qm74 1497 29 , , , cord-015021-pol2qm74 1497 30 M. M. NNP cord-015021-pol2qm74 1497 31 C. C. NNP cord-015021-pol2qm74 1497 32 Gutowski Gutowski NNP cord-015021-pol2qm74 1497 33 , , , cord-015021-pol2qm74 1497 34 V. V. NNP cord-015021-pol2qm74 1497 35 Banssillon Banssillon NNP cord-015021-pol2qm74 1497 36 and and CC cord-015021-pol2qm74 1497 37 J. J. NNP cord-015021-pol2qm74 1497 38 Bienvenu Bienvenu NNP cord-015021-pol2qm74 1497 39 . . . cord-015021-pol2qm74 1498 1 I -PRON- PRP cord-015021-pol2qm74 1498 2 AIM aim VBP cord-015021-pol2qm74 1498 3 OF of IN cord-015021-pol2qm74 1498 4 THE the DT cord-015021-pol2qm74 1498 5 STUDY study NN cord-015021-pol2qm74 1498 6 . . . cord-015021-pol2qm74 1499 1 Increased increase VBN cord-015021-pol2qm74 1499 2 levels level NNS cord-015021-pol2qm74 1499 3 of of IN cord-015021-pol2qm74 1499 4 TNF TNF NNP cord-015021-pol2qm74 1499 5 are be VBP cord-015021-pol2qm74 1499 6 inconsistently inconsistently RB cord-015021-pol2qm74 1499 7 correlated correlate VBN cord-015021-pol2qm74 1499 8 with with IN cord-015021-pol2qm74 1499 9 the the DT cord-015021-pol2qm74 1499 10 severity severity NN cord-015021-pol2qm74 1499 11 of of IN cord-015021-pol2qm74 1499 12 sepsis sepsis NN cord-015021-pol2qm74 1499 13 . . . cord-015021-pol2qm74 1500 1 One one CD cord-015021-pol2qm74 1500 2 possible possible JJ cord-015021-pol2qm74 1500 3 explanation explanation NN cord-015021-pol2qm74 1500 4 is be VBZ cord-015021-pol2qm74 1500 5 a a DT cord-015021-pol2qm74 1500 6 decrease decrease NN cord-015021-pol2qm74 1500 7 ability ability NN cord-015021-pol2qm74 1500 8 of of IN cord-015021-pol2qm74 1500 9 ceils ceil NNS cord-015021-pol2qm74 1500 10 to to TO cord-015021-pol2qm74 1500 11 produce produce VB cord-015021-pol2qm74 1500 12 eytokines eytokine NNS cord-015021-pol2qm74 1500 13 . . . cord-015021-pol2qm74 1501 1 The the DT cord-015021-pol2qm74 1501 2 objectives objective NNS cord-015021-pol2qm74 1501 3 of of IN cord-015021-pol2qm74 1501 4 this this DT cord-015021-pol2qm74 1501 5 study study NN cord-015021-pol2qm74 1501 6 were be VBD cord-015021-pol2qm74 1501 7 m m NNP cord-015021-pol2qm74 1501 8 compare compare NN cord-015021-pol2qm74 1501 9 at at IN cord-015021-pol2qm74 1501 10 different different JJ cord-015021-pol2qm74 1501 11 levels level NNS cord-015021-pol2qm74 1501 12 of of IN cord-015021-pol2qm74 1501 13 of of IN cord-015021-pol2qm74 1501 14 clinical clinical JJ cord-015021-pol2qm74 1501 15 severity severity NN cord-015021-pol2qm74 1501 16 the the DT cord-015021-pol2qm74 1501 17 responsiveness responsiveness NN cord-015021-pol2qm74 1501 18 of of IN cord-015021-pol2qm74 1501 19 cytokine cytokine NN cord-015021-pol2qm74 1501 20 producing produce VBG cord-015021-pol2qm74 1501 21 cells cell NNS cord-015021-pol2qm74 1501 22 . . . cord-015021-pol2qm74 1502 1 This this DT cord-015021-pol2qm74 1502 2 was be VBD cord-015021-pol2qm74 1502 3 evaluated evaluate VBN cord-015021-pol2qm74 1502 4 by by IN cord-015021-pol2qm74 1502 5 the the DT cord-015021-pol2qm74 1502 6 response response NN cord-015021-pol2qm74 1502 7 to to IN cord-015021-pol2qm74 1502 8 a a DT cord-015021-pol2qm74 1502 9 stimulation stimulation NN cord-015021-pol2qm74 1502 10 by by IN cord-015021-pol2qm74 1502 11 LPS lp NNS cord-015021-pol2qm74 1502 12 as as RB cord-015021-pol2qm74 1502 13 well well RB cord-015021-pol2qm74 1502 14 as as IN cord-015021-pol2qm74 1502 15 to to IN cord-015021-pol2qm74 1502 16 the the DT cord-015021-pol2qm74 1502 17 inhibitory inhibitory JJ cord-015021-pol2qm74 1502 18 effect effect NN cord-015021-pol2qm74 1502 19 of of IN cord-015021-pol2qm74 1502 20 PTX PTX NNP cord-015021-pol2qm74 1502 21 . . . cord-015021-pol2qm74 1503 1 The the DT cord-015021-pol2qm74 1503 2 technic technic NN cord-015021-pol2qm74 1503 3 used use VBN cord-015021-pol2qm74 1503 4 is be VBZ cord-015021-pol2qm74 1503 5 a a DT cord-015021-pol2qm74 1503 6 whole whole JJ cord-015021-pol2qm74 1503 7 blood blood NN cord-015021-pol2qm74 1503 8 ex ex NN cord-015021-pol2qm74 1503 9 - - JJ cord-015021-pol2qm74 1503 10 vivo vivo JJ cord-015021-pol2qm74 1503 11 model model NN cord-015021-pol2qm74 1503 12 , , , cord-015021-pol2qm74 1503 13 as as IN cord-015021-pol2qm74 1503 14 described describe VBN cord-015021-pol2qm74 1503 15 by by IN cord-015021-pol2qm74 1503 16 DESCH DESCH NNP cord-015021-pol2qm74 1503 17 et et FW cord-015021-pol2qm74 1503 18 al al NNP cord-015021-pol2qm74 1503 19 . . . cord-015021-pol2qm74 1504 1 ( ( -LRB- cord-015021-pol2qm74 1504 2 1 1 CD cord-015021-pol2qm74 1504 3 ) ) -RRB- cord-015021-pol2qm74 1504 4 . . . cord-015021-pol2qm74 1505 1 H h NN cord-015021-pol2qm74 1505 2 MATERIALS materials NN cord-015021-pol2qm74 1505 3 AND and CC cord-015021-pol2qm74 1505 4 METHODS methods NN cord-015021-pol2qm74 1505 5 . . . cord-015021-pol2qm74 1506 1 Different different JJ cord-015021-pol2qm74 1506 2 groups group NNS cord-015021-pol2qm74 1506 3 of of IN cord-015021-pol2qm74 1506 4 ICU ICU NNP cord-015021-pol2qm74 1506 5 patients patient NNS cord-015021-pol2qm74 1506 6 , , , cord-015021-pol2qm74 1506 7 postoperative postoperative JJ cord-015021-pol2qm74 1506 8 ( ( -LRB- cord-015021-pol2qm74 1506 9 n=12 n=12 NNP cord-015021-pol2qm74 1506 10 ) ) -RRB- cord-015021-pol2qm74 1506 11 , , , cord-015021-pol2qm74 1506 12 sepsis sepsis NN cord-015021-pol2qm74 1506 13 ( ( -LRB- cord-015021-pol2qm74 1506 14 n=12 n=12 NNP cord-015021-pol2qm74 1506 15 ) ) -RRB- cord-015021-pol2qm74 1506 16 , , , cord-015021-pol2qm74 1506 17 septick septick NNP cord-015021-pol2qm74 1506 18 shock shock NNP cord-015021-pol2qm74 1506 19 ( ( -LRB- cord-015021-pol2qm74 1506 20 n=13 n=13 NNP cord-015021-pol2qm74 1506 21 ) ) -RRB- cord-015021-pol2qm74 1506 22 , , , cord-015021-pol2qm74 1506 23 and and CC cord-015021-pol2qm74 1506 24 healthy healthy JJ cord-015021-pol2qm74 1506 25 control control NN cord-015021-pol2qm74 1506 26 ( ( -LRB- cord-015021-pol2qm74 1506 27 n=10 n=10 NNP cord-015021-pol2qm74 1506 28 ) ) -RRB- cord-015021-pol2qm74 1506 29 , , , cord-015021-pol2qm74 1506 30 were be VBD cord-015021-pol2qm74 1506 31 studied study VBN cord-015021-pol2qm74 1506 32 . . . cord-015021-pol2qm74 1507 1 Blood blood NN cord-015021-pol2qm74 1507 2 was be VBD cord-015021-pol2qm74 1507 3 drawn draw VBN cord-015021-pol2qm74 1507 4 in in IN cord-015021-pol2qm74 1507 5 endotoxio endotoxio NNP cord-015021-pol2qm74 1507 6 free free JJ cord-015021-pol2qm74 1507 7 heparinized heparinized JJ cord-015021-pol2qm74 1507 8 robes robe NNS cord-015021-pol2qm74 1507 9 . . . cord-015021-pol2qm74 1508 1 Stimulation stimulation NN cord-015021-pol2qm74 1508 2 was be VBD cord-015021-pol2qm74 1508 3 achieved achieve VBN cord-015021-pol2qm74 1508 4 by by IN cord-015021-pol2qm74 1508 5 addition addition NN cord-015021-pol2qm74 1508 6 nf75 nf75 NNP cord-015021-pol2qm74 1508 7 pl pl NNP cord-015021-pol2qm74 1508 8 ofLPS ofLPS NNP cord-015021-pol2qm74 1508 9 ( ( -LRB- cord-015021-pol2qm74 1508 10 10ng 10ng NNP cord-015021-pol2qm74 1508 11 / / SYM cord-015021-pol2qm74 1508 12 ml ml NN cord-015021-pol2qm74 1508 13 ) ) -RRB- cord-015021-pol2qm74 1508 14 to to IN cord-015021-pol2qm74 1508 15 675 675 CD cord-015021-pol2qm74 1508 16 I -PRON- PRP cord-015021-pol2qm74 1508 17 d d NN cord-015021-pol2qm74 1508 18 of of IN cord-015021-pol2qm74 1508 19 whole whole JJ cord-015021-pol2qm74 1508 20 blood blood NN cord-015021-pol2qm74 1508 21 in in IN cord-015021-pol2qm74 1508 22 presence presence NN cord-015021-pol2qm74 1508 23 of of IN cord-015021-pol2qm74 1508 24 various various JJ cord-015021-pol2qm74 1508 25 concentrations concentration NNS cord-015021-pol2qm74 1508 26 of of IN cord-015021-pol2qm74 1508 27 PTX PTX NNP cord-015021-pol2qm74 1508 28 ( ( -LRB- cord-015021-pol2qm74 1508 29 0 0 CD cord-015021-pol2qm74 1508 30 , , , cord-015021-pol2qm74 1508 31 10 10 CD cord-015021-pol2qm74 1508 32 " " `` cord-015021-pol2qm74 1508 33 5 5 CD cord-015021-pol2qm74 1508 34 , , , cord-015021-pol2qm74 1508 35 10 10 CD cord-015021-pol2qm74 1508 36 -4 -4 NNS cord-015021-pol2qm74 1508 37 , , , cord-015021-pol2qm74 1508 38 10 10 CD cord-015021-pol2qm74 1508 39 " " `` cord-015021-pol2qm74 1508 40 3 3 CD cord-015021-pol2qm74 1508 41 , , , cord-015021-pol2qm74 1508 42 I0"2 I0"2 NNP cord-015021-pol2qm74 1508 43 M M NNP cord-015021-pol2qm74 1508 44 ) ) -RRB- cord-015021-pol2qm74 1508 45 . . . cord-015021-pol2qm74 1509 1 After after IN cord-015021-pol2qm74 1509 2 5 5 CD cord-015021-pol2qm74 1509 3 hrs hrs NN cord-015021-pol2qm74 1509 4 incubation incubation NN cord-015021-pol2qm74 1509 5 at at IN cord-015021-pol2qm74 1509 6 37 37 CD cord-015021-pol2qm74 1509 7 ° ° NN cord-015021-pol2qm74 1509 8 C c NN cord-015021-pol2qm74 1509 9 , , , cord-015021-pol2qm74 1509 10 the the DT cord-015021-pol2qm74 1509 11 tubes tube NNS cord-015021-pol2qm74 1509 12 were be VBD cord-015021-pol2qm74 1509 13 centrifuged centrifuge VBN cord-015021-pol2qm74 1509 14 and and CC cord-015021-pol2qm74 1509 15 supematants supematant NNS cord-015021-pol2qm74 1509 16 frozen freeze VBN cord-015021-pol2qm74 1509 17 at at IN cord-015021-pol2qm74 1509 18 -80 -80 NNP cord-015021-pol2qm74 1509 19 ° ° NN cord-015021-pol2qm74 1509 20 C C NNP cord-015021-pol2qm74 1509 21 . . . cord-015021-pol2qm74 1510 1 TNFa TNFa NNP cord-015021-pol2qm74 1510 2 and and CC cord-015021-pol2qm74 1510 3 / / SYM cord-015021-pol2qm74 1510 4 L6 L6 NNP cord-015021-pol2qm74 1510 5 were be VBD cord-015021-pol2qm74 1510 6 measured measure VBN cord-015021-pol2qm74 1510 7 by by IN cord-015021-pol2qm74 1510 8 ELISA ELISA NNP cord-015021-pol2qm74 1510 9 ( ( -LRB- cord-015021-pol2qm74 1510 10 Medgenix Medgenix NNP cord-015021-pol2qm74 1510 11 R R NNP cord-015021-pol2qm74 1510 12 and and CC cord-015021-pol2qm74 1510 13 Immunotech Immunotech NNP cord-015021-pol2qm74 1510 14 R R NNP cord-015021-pol2qm74 1510 15 respectively respectively RB cord-015021-pol2qm74 1510 16 ) ) -RRB- cord-015021-pol2qm74 1510 17 . . . cord-015021-pol2qm74 1511 1 Monocytes monocyte NNS cord-015021-pol2qm74 1511 2 were be VBD cord-015021-pol2qm74 1511 3 quantified quantify VBN cord-015021-pol2qm74 1511 4 on on IN cord-015021-pol2qm74 1511 5 a a DT cord-015021-pol2qm74 1511 6 Technicon Technicon NNP cord-015021-pol2qm74 1511 7 H6000 h6000 NN cord-015021-pol2qm74 1511 8 . . . cord-015021-pol2qm74 1512 1 The the DT cord-015021-pol2qm74 1512 2 results result NNS cord-015021-pol2qm74 1512 3 are be VBP cord-015021-pol2qm74 1512 4 expressed express VBN cord-015021-pol2qm74 1512 5 as as IN cord-015021-pol2qm74 1512 6 median median JJ cord-015021-pol2qm74 1512 7 values value NNS cord-015021-pol2qm74 1512 8 . . . cord-015021-pol2qm74 1513 1 Non non JJ cord-015021-pol2qm74 1513 2 parametric parametric JJ cord-015021-pol2qm74 1513 3 tests test NNS cord-015021-pol2qm74 1513 4 are be VBP cord-015021-pol2qm74 1513 5 used use VBN cord-015021-pol2qm74 1513 6 for for IN cord-015021-pol2qm74 1513 7 testing test VBG cord-015021-pol2qm74 1513 8 differences difference NNS cord-015021-pol2qm74 1513 9 between between IN cord-015021-pol2qm74 1513 10 groups group NNS cord-015021-pol2qm74 1513 11 . . . cord-015021-pol2qm74 1514 1 HI HI NNP cord-015021-pol2qm74 1514 2 RESULTS result NNS cord-015021-pol2qm74 1514 3 , , , cord-015021-pol2qm74 1514 4 TNFtx TNFtx NNP cord-015021-pol2qm74 1514 5 and and CC cord-015021-pol2qm74 1514 6 11,6 11,6 CD cord-015021-pol2qm74 1514 7 , , , cord-015021-pol2qm74 1514 8 corrected correct VBN cord-015021-pol2qm74 1514 9 for for IN cord-015021-pol2qm74 1514 10 monocytes monocyte NNS cord-015021-pol2qm74 1514 11 count count NN cord-015021-pol2qm74 1514 12 , , , cord-015021-pol2qm74 1514 13 are be VBP cord-015021-pol2qm74 1514 14 given give VBN cord-015021-pol2qm74 1514 15 as as IN cord-015021-pol2qm74 1514 16 % % NN cord-015021-pol2qm74 1514 17 of of IN cord-015021-pol2qm74 1514 18 their -PRON- PRP$ cord-015021-pol2qm74 1514 19 initial initial JJ cord-015021-pol2qm74 1514 20 value value NN cord-015021-pol2qm74 1514 21 , , , cord-015021-pol2qm74 1514 22 the the DT cord-015021-pol2qm74 1514 23 baseline baseline NN cord-015021-pol2qm74 1514 24 before before IN cord-015021-pol2qm74 1514 25 stimulation stimulation NN cord-015021-pol2qm74 1514 26 or or CC cord-015021-pol2qm74 1514 27 inhibition inhibition NN cord-015021-pol2qm74 1514 28 being be VBG cord-015021-pol2qm74 1514 29 100 100 CD cord-015021-pol2qm74 1514 30 % % NN cord-015021-pol2qm74 1514 31 , , , cord-015021-pol2qm74 1514 32 1 1 CD cord-015021-pol2qm74 1514 33 ) ) -RRB- cord-015021-pol2qm74 1514 34 STIMULATION stimulation NN cord-015021-pol2qm74 1514 35 BY by IN cord-015021-pol2qm74 1514 36 LPS lp NNS cord-015021-pol2qm74 1514 37 . . . cord-015021-pol2qm74 1515 1 The the DT cord-015021-pol2qm74 1515 2 control control NN cord-015021-pol2qm74 1515 3 group group NN cord-015021-pol2qm74 1515 4 is be VBZ cord-015021-pol2qm74 1515 5 much much RB cord-015021-pol2qm74 1515 6 more more RBR cord-015021-pol2qm74 1515 7 stimulated stimulated JJ cord-015021-pol2qm74 1515 8 ( ( -LRB- cord-015021-pol2qm74 1515 9 > > XX cord-015021-pol2qm74 1516 1 21000 21000 CD cord-015021-pol2qm74 1516 2 % % NN cord-015021-pol2qm74 1516 3 for for IN cord-015021-pol2qm74 1516 4 IL6 il6 NN cord-015021-pol2qm74 1516 5 , , , cord-015021-pol2qm74 1516 6 > > XX cord-015021-pol2qm74 1516 7 8000 8000 CD cord-015021-pol2qm74 1516 8 % % NN cord-015021-pol2qm74 1516 9 for for IN cord-015021-pol2qm74 1516 10 TNFa TNFa NNS cord-015021-pol2qm74 1516 11 ) ) -RRB- cord-015021-pol2qm74 1516 12 . . . cord-015021-pol2qm74 1517 1 Blood blood NN cord-015021-pol2qm74 1517 2 samples sample NNS cord-015021-pol2qm74 1517 3 taken take VBN cord-015021-pol2qm74 1517 4 postoperatively postoperatively RB cord-015021-pol2qm74 1517 5 and and CC cord-015021-pol2qm74 1517 6 in in IN cord-015021-pol2qm74 1517 7 patients patient NNS cord-015021-pol2qm74 1517 8 with with IN cord-015021-pol2qm74 1517 9 simple simple JJ cord-015021-pol2qm74 1517 10 sepsis sepsis NN cord-015021-pol2qm74 1517 11 are be VBP cord-015021-pol2qm74 1517 12 significantly significantly RB cord-015021-pol2qm74 1517 13 less less RBR cord-015021-pol2qm74 1517 14 stimulated stimulate VBN cord-015021-pol2qm74 1517 15 ( ( -LRB- cord-015021-pol2qm74 1517 16 > > NFP cord-015021-pol2qm74 1517 17 1500 1500 CD cord-015021-pol2qm74 1517 18 % % NN cord-015021-pol2qm74 1517 19 for for IN cord-015021-pol2qm74 1517 20 IL6 il6 NN cord-015021-pol2qm74 1517 21 , , , cord-015021-pol2qm74 1517 22 > > XX cord-015021-pol2qm74 1517 23 600 600 CD cord-015021-pol2qm74 1517 24 % % NN cord-015021-pol2qm74 1517 25 for for IN cord-015021-pol2qm74 1517 26 TNFa TNFa NNS cord-015021-pol2qm74 1517 27 ) ) -RRB- cord-015021-pol2qm74 1517 28 . . . cord-015021-pol2qm74 1518 1 The the DT cord-015021-pol2qm74 1518 2 lowest low JJS cord-015021-pol2qm74 1518 3 stimulation stimulation NN cord-015021-pol2qm74 1518 4 was be VBD cord-015021-pol2qm74 1518 5 observed observe VBN cord-015021-pol2qm74 1518 6 in in IN cord-015021-pol2qm74 1518 7 patients patient NNS cord-015021-pol2qm74 1518 8 with with IN cord-015021-pol2qm74 1518 9 septic septic JJ cord-015021-pol2qm74 1518 10 shock shock NN cord-015021-pol2qm74 1518 11 ( ( -LRB- cord-015021-pol2qm74 1518 12 median median NN cord-015021-pol2qm74 1518 13 = = SYM cord-015021-pol2qm74 1518 14 168 168 CD cord-015021-pol2qm74 1518 15 % % NN cord-015021-pol2qm74 1518 16 ) ) -RRB- cord-015021-pol2qm74 1518 17 , , , cord-015021-pol2qm74 1518 18 some some DT cord-015021-pol2qm74 1518 19 patients patient NNS cord-015021-pol2qm74 1518 20 being be VBG cord-015021-pol2qm74 1518 21 not not RB cord-015021-pol2qm74 1518 22 stimulated stimulate VBN cord-015021-pol2qm74 1518 23 at at RB cord-015021-pol2qm74 1518 24 all all RB cord-015021-pol2qm74 1518 25 . . . cord-015021-pol2qm74 1519 1 2)EFFECTS 2)effects CD cord-015021-pol2qm74 1520 1 OF of IN cord-015021-pol2qm74 1520 2 PTX.The PTX.The NNP cord-015021-pol2qm74 1520 3 inhibitory inhibitory JJ cord-015021-pol2qm74 1520 4 effect effect NN cord-015021-pol2qm74 1520 5 of of IN cord-015021-pol2qm74 1520 6 PTX PTX NNP cord-015021-pol2qm74 1520 7 on on IN cord-015021-pol2qm74 1520 8 TNFtx tnftx DT cord-015021-pol2qm74 1520 9 production production NN cord-015021-pol2qm74 1520 10 is be VBZ cord-015021-pol2qm74 1520 11 effective effective JJ cord-015021-pol2qm74 1520 12 in in IN cord-015021-pol2qm74 1520 13 all all DT cord-015021-pol2qm74 1520 14 groups group NNS cord-015021-pol2qm74 1520 15 at at IN cord-015021-pol2qm74 1520 16 10 10 CD cord-015021-pol2qm74 1520 17 -3 -3 NNP cord-015021-pol2qm74 1520 18 M M NNP cord-015021-pol2qm74 1520 19 ( ( -LRB- cord-015021-pol2qm74 1520 20 reduction reduction NN cord-015021-pol2qm74 1520 21 to to IN cord-015021-pol2qm74 1520 22 less less JJR cord-015021-pol2qm74 1520 23 than than IN cord-015021-pol2qm74 1520 24 ' ' '' cord-015021-pol2qm74 1520 25 ¼ ¼ CD cord-015021-pol2qm74 1520 26 of of IN cord-015021-pol2qm74 1520 27 the the DT cord-015021-pol2qm74 1520 28 median median JJ cord-015021-pol2qm74 1520 29 values value NNS cord-015021-pol2qm74 1520 30 ) ) -RRB- cord-015021-pol2qm74 1520 31 , , , cord-015021-pol2qm74 1520 32 and and CC cord-015021-pol2qm74 1520 33 is be VBZ cord-015021-pol2qm74 1520 34 almost almost RB cord-015021-pol2qm74 1520 35 complete complete JJ cord-015021-pol2qm74 1520 36 at at IN cord-015021-pol2qm74 1520 37 10 10 CD cord-015021-pol2qm74 1520 38 " " `` cord-015021-pol2qm74 1520 39 2 2 CD cord-015021-pol2qm74 1520 40 M. m. NN cord-015021-pol2qm74 1521 1 The the DT cord-015021-pol2qm74 1521 2 septic septic JJ cord-015021-pol2qm74 1521 3 shock shock NN cord-015021-pol2qm74 1521 4 group group NN cord-015021-pol2qm74 1521 5 has have VBZ cord-015021-pol2qm74 1521 6 a a DT cord-015021-pol2qm74 1521 7 decreased decrease VBN cord-015021-pol2qm74 1521 8 sensitivity sensitivity NN cord-015021-pol2qm74 1521 9 to to IN cord-015021-pol2qm74 1521 10 PTX PTX NNP cord-015021-pol2qm74 1521 11 . . . cord-015021-pol2qm74 1522 1 IL6 il6 NN cord-015021-pol2qm74 1522 2 production production NN cord-015021-pol2qm74 1522 3 exhibits exhibit VBZ cord-015021-pol2qm74 1522 4 a a DT cord-015021-pol2qm74 1522 5 lesser less JJR cord-015021-pol2qm74 1522 6 reduction reduction NN cord-015021-pol2qm74 1522 7 at at IN cord-015021-pol2qm74 1522 8 10 10 CD cord-015021-pol2qm74 1522 9 -3 -3 NNP cord-015021-pol2qm74 1522 10 M M NNP cord-015021-pol2qm74 1522 11 ( ( -LRB- cord-015021-pol2qm74 1522 12 ~ ~ NFP cord-015021-pol2qm74 1522 13 ' ' '' cord-015021-pol2qm74 1522 14 A a DT cord-015021-pol2qm74 1522 15 to to IN cord-015021-pol2qm74 1522 16 ½ ½ NN cord-015021-pol2qm74 1522 17 of of IN cord-015021-pol2qm74 1522 18 the the DT cord-015021-pol2qm74 1522 19 median median JJ cord-015021-pol2qm74 1522 20 values value NNS cord-015021-pol2qm74 1522 21 ) ) -RRB- cord-015021-pol2qm74 1522 22 , , , cord-015021-pol2qm74 1522 23 further further RB cord-015021-pol2qm74 1522 24 increased increase VBD cord-015021-pol2qm74 1522 25 at at IN cord-015021-pol2qm74 1522 26 10 10 CD cord-015021-pol2qm74 1522 27 -2 -2 NN cord-015021-pol2qm74 1522 28 M. m. NN cord-015021-pol2qm74 1523 1 The the DT cord-015021-pol2qm74 1523 2 septic septic JJ cord-015021-pol2qm74 1523 3 shock shock NN cord-015021-pol2qm74 1523 4 group group NN cord-015021-pol2qm74 1523 5 is be VBZ cord-015021-pol2qm74 1523 6 again again RB cord-015021-pol2qm74 1523 7 less less RBR cord-015021-pol2qm74 1523 8 sensitive sensitive JJ cord-015021-pol2qm74 1523 9 to to IN cord-015021-pol2qm74 1523 10 PTX PTX NNP cord-015021-pol2qm74 1523 11 . . . cord-015021-pol2qm74 1524 1 IV IV NNP cord-015021-pol2qm74 1524 2 CONCLUSION CONCLUSION NNP cord-015021-pol2qm74 1524 3 : : : cord-015021-pol2qm74 1525 1 The the DT cord-015021-pol2qm74 1525 2 reduced reduce VBN cord-015021-pol2qm74 1525 3 ability ability NN cord-015021-pol2qm74 1525 4 of of IN cord-015021-pol2qm74 1525 5 circulating circulate VBG cord-015021-pol2qm74 1525 6 monocytes monocyte NNS cord-015021-pol2qm74 1525 7 to to TO cord-015021-pol2qm74 1525 8 produce produce VB cord-015021-pol2qm74 1525 9 cytokines cytokine NNS cord-015021-pol2qm74 1525 10 during during IN cord-015021-pol2qm74 1525 11 severe severe JJ cord-015021-pol2qm74 1525 12 infections infection NNS cord-015021-pol2qm74 1525 13 is be VBZ cord-015021-pol2qm74 1525 14 confirmed confirm VBN cord-015021-pol2qm74 1525 15 here here RB cord-015021-pol2qm74 1525 16 . . . cord-015021-pol2qm74 1526 1 PTX PTX NNP cord-015021-pol2qm74 1526 2 is be VBZ cord-015021-pol2qm74 1526 3 able able JJ cord-015021-pol2qm74 1526 4 to to TO cord-015021-pol2qm74 1526 5 reduce reduce VB cord-015021-pol2qm74 1526 6 significantly significantly RB cord-015021-pol2qm74 1526 7 TNFc~ tnfc~ CD cord-015021-pol2qm74 1526 8 at at IN cord-015021-pol2qm74 1526 9 10 10 CD cord-015021-pol2qm74 1526 10 -3 -3 NNP cord-015021-pol2qm74 1526 11 M M NNP cord-015021-pol2qm74 1526 12 and and CC cord-015021-pol2qm74 1526 13 the the DT cord-015021-pol2qm74 1526 14 inhibition inhibition NN cord-015021-pol2qm74 1526 15 is be VBZ cord-015021-pol2qm74 1526 16 nearly nearly RB cord-015021-pol2qm74 1526 17 complete complete JJ cord-015021-pol2qm74 1526 18 at at IN cord-015021-pol2qm74 1526 19 10 10 CD cord-015021-pol2qm74 1526 20 -2 -2 NN cord-015021-pol2qm74 1526 21 M. m. NN cord-015021-pol2qm74 1527 1 Surprisingly surprisingly RB cord-015021-pol2qm74 1527 2 , , , cord-015021-pol2qm74 1527 3 there there EX cord-015021-pol2qm74 1527 4 is be VBZ cord-015021-pol2qm74 1527 5 a a DT cord-015021-pol2qm74 1527 6 lesser less JJR cord-015021-pol2qm74 1527 7 , , , cord-015021-pol2qm74 1527 8 but but CC cord-015021-pol2qm74 1527 9 significant significant JJ cord-015021-pol2qm74 1527 10 suppressive suppressive JJ cord-015021-pol2qm74 1527 11 action action NN cord-015021-pol2qm74 1527 12 of of IN cord-015021-pol2qm74 1527 13 PTX PTX NNP cord-015021-pol2qm74 1527 14 on on IN cord-015021-pol2qm74 1527 15 IL6 IL6 NNP cord-015021-pol2qm74 1527 16 , , , cord-015021-pol2qm74 1527 17 not not RB cord-015021-pol2qm74 1527 18 found find VBN cord-015021-pol2qm74 1527 19 in in IN cord-015021-pol2qm74 1527 20 experiments experiment NNS cord-015021-pol2qm74 1527 21 using use VBG cord-015021-pol2qm74 1527 22 purified purify VBN cord-015021-pol2qm74 1527 23 monocytes monocyte NNS cord-015021-pol2qm74 1527 24 . . . cord-015021-pol2qm74 1528 1 One one CD cord-015021-pol2qm74 1528 2 possible possible JJ cord-015021-pol2qm74 1528 3 explination explination NN cord-015021-pol2qm74 1528 4 could could MD cord-015021-pol2qm74 1528 5 be be VB cord-015021-pol2qm74 1528 6 the the DT cord-015021-pol2qm74 1528 7 interplay interplay NN cord-015021-pol2qm74 1528 8 between between IN cord-015021-pol2qm74 1528 9 cytokines cytokine NNS cord-015021-pol2qm74 1528 10 production production NN cord-015021-pol2qm74 1528 11 . . . cord-015021-pol2qm74 1529 1 ( ( -LRB- cord-015021-pol2qm74 1529 2 1 1 CD cord-015021-pol2qm74 1529 3 ) ) -RRB- cord-015021-pol2qm74 1530 1 Lymphokine lymphokine NN cord-015021-pol2qm74 1530 2 research research NN cord-015021-pol2qm74 1530 3 ( ( -LRB- cord-015021-pol2qm74 1531 1 1989 1989 LS cord-015021-pol2qm74 1531 2 ) ) -RRB- cord-015021-pol2qm74 1531 3 cDNA cdna NN cord-015021-pol2qm74 1531 4 sequencing sequencing NN cord-015021-pol2qm74 1531 5 constitutes constitute VBZ cord-015021-pol2qm74 1531 6 a a DT cord-015021-pol2qm74 1531 7 powerful powerful JJ cord-015021-pol2qm74 1531 8 method method NN cord-015021-pol2qm74 1531 9 of of IN cord-015021-pol2qm74 1531 10 measuring measure VBG cord-015021-pol2qm74 1531 11 steady steady JJ cord-015021-pol2qm74 1531 12 - - HYPH cord-015021-pol2qm74 1531 13 state state NN cord-015021-pol2qm74 1531 14 mRNA mrna NN cord-015021-pol2qm74 1531 15 levels level NNS cord-015021-pol2qm74 1531 16 for for IN cord-015021-pol2qm74 1531 17 all all DT cord-015021-pol2qm74 1531 18 genes gene NNS cord-015021-pol2qm74 1531 19 transcribed transcribe VBN cord-015021-pol2qm74 1531 20 in in IN cord-015021-pol2qm74 1531 21 a a DT cord-015021-pol2qm74 1531 22 given give VBN cord-015021-pol2qm74 1531 23 cell cell NN cord-015021-pol2qm74 1531 24 or or CC cord-015021-pol2qm74 1531 25 tissue tissue NN cord-015021-pol2qm74 1531 26 at at IN cord-015021-pol2qm74 1531 27 a a DT cord-015021-pol2qm74 1531 28 particular particular JJ cord-015021-pol2qm74 1531 29 stage stage NN cord-015021-pol2qm74 1531 30 of of IN cord-015021-pol2qm74 1531 31 differentiation differentiation NN cord-015021-pol2qm74 1531 32 . . . cord-015021-pol2qm74 1532 1 By by IN cord-015021-pol2qm74 1532 2 comparing compare VBG cord-015021-pol2qm74 1532 3 transcript transcript NN cord-015021-pol2qm74 1532 4 abundance abundance NN cord-015021-pol2qm74 1532 5 both both DT cord-015021-pol2qm74 1532 6 prior prior RB cord-015021-pol2qm74 1532 7 to to IN cord-015021-pol2qm74 1532 8 and and CC cord-015021-pol2qm74 1532 9 following follow VBG cord-015021-pol2qm74 1532 10 differentiation differentiation NN cord-015021-pol2qm74 1532 11 , , , cord-015021-pol2qm74 1532 12 individual individual JJ cord-015021-pol2qm74 1532 13 genes gene NNS cord-015021-pol2qm74 1532 14 can can MD cord-015021-pol2qm74 1532 15 be be VB cord-015021-pol2qm74 1532 16 identified identify VBN cord-015021-pol2qm74 1532 17 whose whose WP$ cord-015021-pol2qm74 1532 18 transcription transcription NN cord-015021-pol2qm74 1532 19 is be VBZ cord-015021-pol2qm74 1532 20 regulated regulate VBN cord-015021-pol2qm74 1532 21 both both CC cord-015021-pol2qm74 1532 22 positively positively RB cord-015021-pol2qm74 1532 23 and and CC cord-015021-pol2qm74 1532 24 negatively negatively RB cord-015021-pol2qm74 1532 25 . . . cord-015021-pol2qm74 1533 1 In in IN cord-015021-pol2qm74 1533 2 order order NN cord-015021-pol2qm74 1533 3 to to TO cord-015021-pol2qm74 1533 4 examine examine VB cord-015021-pol2qm74 1533 5 monocyte monocyte NNP cord-015021-pol2qm74 1533 6 activation activation NN cord-015021-pol2qm74 1533 7 , , , cord-015021-pol2qm74 1533 8 the the DT cord-015021-pol2qm74 1533 9 human human JJ cord-015021-pol2qm74 1533 10 monocyte monocyte NNP cord-015021-pol2qm74 1533 11 line line NN cord-015021-pol2qm74 1533 12 THP-1 THP-1 NNP cord-015021-pol2qm74 1533 13 was be VBD cord-015021-pol2qm74 1533 14 induced induce VBN cord-015021-pol2qm74 1533 15 with with IN cord-015021-pol2qm74 1533 16 phorbol phorbol NNP cord-015021-pol2qm74 1533 17 ester ester NNP cord-015021-pol2qm74 1533 18 ( ( -LRB- cord-015021-pol2qm74 1533 19 48 48 CD cord-015021-pol2qm74 1533 20 h h NN cord-015021-pol2qm74 1533 21 ) ) -RRB- cord-015021-pol2qm74 1533 22 and and CC cord-015021-pol2qm74 1533 23 activated activate VBD cord-015021-pol2qm74 1533 24 for for IN cord-015021-pol2qm74 1533 25 4 4 CD cord-015021-pol2qm74 1533 26 h h NN cord-015021-pol2qm74 1533 27 with with IN cord-015021-pol2qm74 1533 28 lipopolysaccharide lipopolysaccharide NN cord-015021-pol2qm74 1533 29 ( ( -LRB- cord-015021-pol2qm74 1533 30 LPS LPS NNP cord-015021-pol2qm74 1533 31 ) ) -RRB- cord-015021-pol2qm74 1533 32 after after IN cord-015021-pol2qm74 1533 33 which which WDT cord-015021-pol2qm74 1533 34 polyA polyA NNP cord-015021-pol2qm74 1533 35 + + CC cord-015021-pol2qm74 1534 1 RNA RNA NNP cord-015021-pol2qm74 1534 2 was be VBD cord-015021-pol2qm74 1534 3 purified purify VBN cord-015021-pol2qm74 1534 4 . . . cord-015021-pol2qm74 1535 1 The the DT cord-015021-pol2qm74 1535 2 RNA RNA NNP cord-015021-pol2qm74 1535 3 from from IN cord-015021-pol2qm74 1535 4 control control NN cord-015021-pol2qm74 1535 5 and and CC cord-015021-pol2qm74 1535 6 LPS LPS NNP cord-015021-pol2qm74 1535 7 - - HYPH cord-015021-pol2qm74 1535 8 treated treat VBN cord-015021-pol2qm74 1535 9 cells cell NNS cord-015021-pol2qm74 1535 10 were be VBD cord-015021-pol2qm74 1535 11 each each DT cord-015021-pol2qm74 1535 12 used use VBN cord-015021-pol2qm74 1535 13 to to TO cord-015021-pol2qm74 1535 14 construct construct VB cord-015021-pol2qm74 1535 15 a a DT cord-015021-pol2qm74 1535 16 cDNA cdna NN cord-015021-pol2qm74 1535 17 library library NN cord-015021-pol2qm74 1535 18 under under IN cord-015021-pol2qm74 1535 19 identical identical JJ cord-015021-pol2qm74 1535 20 conditions condition NNS cord-015021-pol2qm74 1535 21 , , , cord-015021-pol2qm74 1535 22 and and CC cord-015021-pol2qm74 1535 23 all all DT cord-015021-pol2qm74 1535 24 resulting result VBG cord-015021-pol2qm74 1535 25 clones clone NNS cord-015021-pol2qm74 1535 26 were be VBD cord-015021-pol2qm74 1535 27 selected select VBN cord-015021-pol2qm74 1535 28 for for IN cord-015021-pol2qm74 1535 29 cDNA cdna NN cord-015021-pol2qm74 1535 30 sequence sequence NN cord-015021-pol2qm74 1535 31 analysis analysis NN cord-015021-pol2qm74 1535 32 . . . cord-015021-pol2qm74 1536 1 Each each DT cord-015021-pol2qm74 1536 2 clone clone NN cord-015021-pol2qm74 1536 3 sequence sequence NN cord-015021-pol2qm74 1536 4 was be VBD cord-015021-pol2qm74 1536 5 evaluated evaluate VBN cord-015021-pol2qm74 1536 6 by by IN cord-015021-pol2qm74 1536 7 matching match VBG cord-015021-pol2qm74 1536 8 with with IN cord-015021-pol2qm74 1536 9 both both DT cord-015021-pol2qm74 1536 10 GenBank GenBank NNP cord-015021-pol2qm74 1536 11 and and CC cord-015021-pol2qm74 1536 12 our -PRON- PRP$ cord-015021-pol2qm74 1536 13 own own JJ cord-015021-pol2qm74 1536 14 gene gene NN cord-015021-pol2qm74 1536 15 databases database NNS cord-015021-pol2qm74 1536 16 . . . cord-015021-pol2qm74 1537 1 Very very RB cord-015021-pol2qm74 1537 2 different different JJ cord-015021-pol2qm74 1537 3 patterns pattern NNS cord-015021-pol2qm74 1537 4 of of IN cord-015021-pol2qm74 1537 5 gene gene NN cord-015021-pol2qm74 1537 6 expression expression NN cord-015021-pol2qm74 1537 7 were be VBD cord-015021-pol2qm74 1537 8 seen see VBN cord-015021-pol2qm74 1537 9 in in IN cord-015021-pol2qm74 1537 10 the the DT cord-015021-pol2qm74 1537 11 two two CD cord-015021-pol2qm74 1537 12 libraries library NNS cord-015021-pol2qm74 1537 13 , , , cord-015021-pol2qm74 1537 14 the the DT cord-015021-pol2qm74 1537 15 latter latter JJ cord-015021-pol2qm74 1537 16 reflecting reflect VBG cord-015021-pol2qm74 1537 17 very very RB cord-015021-pol2qm74 1537 18 high high JJ cord-015021-pol2qm74 1537 19 levels level NNS cord-015021-pol2qm74 1537 20 of of IN cord-015021-pol2qm74 1537 21 known know VBN cord-015021-pol2qm74 1537 22 inflammatory inflammatory JJ cord-015021-pol2qm74 1537 23 mediators mediator NNS cord-015021-pol2qm74 1537 24 such such JJ cord-015021-pol2qm74 1537 25 as as IN cord-015021-pol2qm74 1537 26 IL-1 IL-1 NNP cord-015021-pol2qm74 1537 27 and and CC cord-015021-pol2qm74 1537 28 TNF TNF NNP cord-015021-pol2qm74 1537 29 . . . cord-015021-pol2qm74 1538 1 A a DT cord-015021-pol2qm74 1538 2 second second JJ cord-015021-pol2qm74 1538 3 set set NN cord-015021-pol2qm74 1538 4 of of IN cord-015021-pol2qm74 1538 5 libraries library NNS cord-015021-pol2qm74 1538 6 were be VBD cord-015021-pol2qm74 1538 7 made make VBN cord-015021-pol2qm74 1538 8 from from IN cord-015021-pol2qm74 1538 9 umbilical umbilical JJ cord-015021-pol2qm74 1538 10 vein vein NN cord-015021-pol2qm74 1538 11 endothelial endothelial JJ cord-015021-pol2qm74 1538 12 cells cell NNS cord-015021-pol2qm74 1538 13 ( ( -LRB- cord-015021-pol2qm74 1538 14 HUVEC HUVEC NNP cord-015021-pol2qm74 1538 15 ) ) -RRB- cord-015021-pol2qm74 1538 16 , , , cord-015021-pol2qm74 1538 17 both both CC cord-015021-pol2qm74 1538 18 with with IN cord-015021-pol2qm74 1538 19 and and CC cord-015021-pol2qm74 1538 20 without without IN cord-015021-pol2qm74 1538 21 LPS LPS NNP cord-015021-pol2qm74 1538 22 stimulation stimulation NN cord-015021-pol2qm74 1538 23 , , , cord-015021-pol2qm74 1538 24 and and CC cord-015021-pol2qm74 1538 25 were be VBD cord-015021-pol2qm74 1538 26 analyzed analyze VBN cord-015021-pol2qm74 1538 27 in in IN cord-015021-pol2qm74 1538 28 a a DT cord-015021-pol2qm74 1538 29 similar similar JJ cord-015021-pol2qm74 1538 30 fashion fashion NN cord-015021-pol2qm74 1538 31 . . . cord-015021-pol2qm74 1539 1 The the DT cord-015021-pol2qm74 1539 2 effects effect NNS cord-015021-pol2qm74 1539 3 of of IN cord-015021-pol2qm74 1539 4 LPS LPS NNP cord-015021-pol2qm74 1539 5 induction induction NN cord-015021-pol2qm74 1539 6 on on IN cord-015021-pol2qm74 1539 7 specific specific JJ cord-015021-pol2qm74 1539 8 gene gene NN cord-015021-pol2qm74 1539 9 transcription transcription NN cord-015021-pol2qm74 1539 10 in in IN cord-015021-pol2qm74 1539 11 both both DT cord-015021-pol2qm74 1539 12 cell cell NN cord-015021-pol2qm74 1539 13 types type NNS cord-015021-pol2qm74 1539 14 will will MD cord-015021-pol2qm74 1539 15 be be VB cord-015021-pol2qm74 1539 16 discussed discuss VBN cord-015021-pol2qm74 1539 17 . . . cord-015021-pol2qm74 1540 1 T. T. NNP cord-015021-pol2qm74 1540 2 Tadros Tadros NNP cord-015021-pol2qm74 1540 3 , , , cord-015021-pol2qm74 1540 4 MD MD NNP cord-015021-pol2qm74 1540 5 , , , cord-015021-pol2qm74 1540 6 Th Th NNP cord-015021-pol2qm74 1540 7 Wobbes Wobbes NNP cord-015021-pol2qm74 1540 8 , , , cord-015021-pol2qm74 1540 9 ME ME NNP cord-015021-pol2qm74 1540 10 ) ) -RRB- cord-015021-pol2qm74 1540 11 PhD phd NN cord-015021-pol2qm74 1540 12 , , , cord-015021-pol2qm74 1540 13 RJA RJA NNP cord-015021-pol2qm74 1540 14 Goris Goris NNP cord-015021-pol2qm74 1540 15 , , , cord-015021-pol2qm74 1540 16 MD MD NNP cord-015021-pol2qm74 1540 17 PhD phd NN cord-015021-pol2qm74 1541 1 To to TO cord-015021-pol2qm74 1541 2 investigate investigate VB cord-015021-pol2qm74 1541 3 whether whether IN cord-015021-pol2qm74 1541 4 the the DT cord-015021-pol2qm74 1541 5 preactivation preactivation NN cord-015021-pol2qm74 1541 6 of of IN cord-015021-pol2qm74 1541 7 regional regional JJ cord-015021-pol2qm74 1541 8 macrophuges macrophuge NNS cord-015021-pol2qm74 1541 9 by by IN cord-015021-pol2qm74 1541 10 liposomes liposome NNS cord-015021-pol2qm74 1541 11 containing contain VBG cord-015021-pol2qm74 1541 12 muramyl muramyl NNP cord-015021-pol2qm74 1541 13 tripeptide tripeptide NNP cord-015021-pol2qm74 1541 14 ( ( -LRB- cord-015021-pol2qm74 1541 15 MTP MTP NNP cord-015021-pol2qm74 1541 16 - - HYPH cord-015021-pol2qm74 1541 17 PE PE NNP cord-015021-pol2qm74 1541 18 ) ) -RRB- cord-015021-pol2qm74 1541 19 can can MD cord-015021-pol2qm74 1541 20 counteract counteract VB cord-015021-pol2qm74 1541 21 the the DT cord-015021-pol2qm74 1541 22 detrimental detrimental JJ cord-015021-pol2qm74 1541 23 effect effect NN cord-015021-pol2qm74 1541 24 of of IN cord-015021-pol2qm74 1541 25 blood blood NN cord-015021-pol2qm74 1541 26 transfusions transfusion NNS cord-015021-pol2qm74 1541 27 on on IN cord-015021-pol2qm74 1541 28 both both DT cord-015021-pol2qm74 1541 29 anastomotic anastomotic JJ cord-015021-pol2qm74 1541 30 repair repair NN cord-015021-pol2qm74 1541 31 and and CC cord-015021-pol2qm74 1541 32 host host NN cord-015021-pol2qm74 1541 33 susceptibility susceptibility NN cord-015021-pol2qm74 1541 34 to to IN cord-015021-pol2qm74 1541 35 infections infection NNS cord-015021-pol2qm74 1541 36 . . . cord-015021-pol2qm74 1542 1 Methods Methods NNPS cord-015021-pol2qm74 1542 2 Eighty eighty CD cord-015021-pol2qm74 1542 3 Lewis Lewis NNP cord-015021-pol2qm74 1542 4 rats rat NNS cord-015021-pol2qm74 1542 5 received receive VBD cord-015021-pol2qm74 1542 6 lmg lmg NNP cord-015021-pol2qm74 1542 7 / / SYM cord-015021-pol2qm74 1542 8 kg kg NNS cord-015021-pol2qm74 1542 9 of of IN cord-015021-pol2qm74 1542 10 either either DT cord-015021-pol2qm74 1542 11 empty empty JJ cord-015021-pol2qm74 1542 12 or or CC cord-015021-pol2qm74 1542 13 MTP MTP NNP cord-015021-pol2qm74 1542 14 - - HYPH cord-015021-pol2qm74 1542 15 PE PE NNP cord-015021-pol2qm74 1542 16 encapsulated encapsulate VBN cord-015021-pol2qm74 1542 17 Liposomes Liposomes NNP cord-015021-pol2qm74 1542 18 , , , cord-015021-pol2qm74 1542 19 intraperitoneally intraperitoneally RB cord-015021-pol2qm74 1542 20 ( ( -LRB- cord-015021-pol2qm74 1542 21 ip ip NN cord-015021-pol2qm74 1542 22 ) ) -RRB- cord-015021-pol2qm74 1542 23 . . . cord-015021-pol2qm74 1543 1 Twenty twenty CD cord-015021-pol2qm74 1543 2 - - HYPH cord-015021-pol2qm74 1543 3 four four CD cord-015021-pol2qm74 1543 4 hours hour NNS cord-015021-pol2qm74 1543 5 thereafter thereafter RB cord-015021-pol2qm74 1543 6 , , , cord-015021-pol2qm74 1543 7 the the DT cord-015021-pol2qm74 1543 8 animals animal NNS cord-015021-pol2qm74 1543 9 underwent undergo VBD cord-015021-pol2qm74 1543 10 resection resection NN cord-015021-pol2qm74 1543 11 and and CC cord-015021-pol2qm74 1543 12 anastomosis anastomosis NN cord-015021-pol2qm74 1543 13 of of IN cord-015021-pol2qm74 1543 14 both both DT cord-015021-pol2qm74 1543 15 ileum ileum NN cord-015021-pol2qm74 1543 16 and and CC cord-015021-pol2qm74 1543 17 colon colon NN cord-015021-pol2qm74 1543 18 , , , cord-015021-pol2qm74 1543 19 and and CC cord-015021-pol2qm74 1543 20 received receive VBD cord-015021-pol2qm74 1543 21 3 3 CD cord-015021-pol2qm74 1543 22 mL ml NN cord-015021-pol2qm74 1543 23 of of IN cord-015021-pol2qm74 1543 24 either either DT cord-015021-pol2qm74 1543 25 saline saline NN cord-015021-pol2qm74 1543 26 or or CC cord-015021-pol2qm74 1543 27 blood blood NN cord-015021-pol2qm74 1543 28 from from IN cord-015021-pol2qm74 1543 29 brown brown JJ cord-015021-pol2qm74 1543 30 Norway Norway NNP cord-015021-pol2qm74 1543 31 donors donor NNS cord-015021-pol2qm74 1543 32 , , , cord-015021-pol2qm74 1544 1 iv iv LS cord-015021-pol2qm74 1544 2 . . . cord-015021-pol2qm74 1545 1 The the DT cord-015021-pol2qm74 1545 2 animals animal NNS cord-015021-pol2qm74 1545 3 were be VBD cord-015021-pol2qm74 1545 4 killed kill VBN cord-015021-pol2qm74 1545 5 3 3 CD cord-015021-pol2qm74 1545 6 or or CC cord-015021-pol2qm74 1545 7 7 7 CD cord-015021-pol2qm74 1545 8 days day NNS cord-015021-pol2qm74 1545 9 after after IN cord-015021-pol2qm74 1545 10 surgery surgery NN cord-015021-pol2qm74 1545 11 and and CC cord-015021-pol2qm74 1545 12 examined examine VBD cord-015021-pol2qm74 1545 13 for for IN cord-015021-pol2qm74 1545 14 septic septic JJ cord-015021-pol2qm74 1545 15 complications complication NNS cord-015021-pol2qm74 1545 16 and and CC cord-015021-pol2qm74 1545 17 anastomotic anastomotic JJ cord-015021-pol2qm74 1545 18 repair repair NN cord-015021-pol2qm74 1545 19 . . . cord-015021-pol2qm74 1546 1 The the DT cord-015021-pol2qm74 1546 2 average average JJ cord-015021-pol2qm74 1546 3 anastomotic anastomotic JJ cord-015021-pol2qm74 1546 4 strength strength NN cord-015021-pol2qm74 1546 5 , , , cord-015021-pol2qm74 1546 6 as as IN cord-015021-pol2qm74 1546 7 assessed assess VBN cord-015021-pol2qm74 1546 8 by by IN cord-015021-pol2qm74 1546 9 bursting burst VBG cord-015021-pol2qm74 1546 10 pressure pressure NN cord-015021-pol2qm74 1546 11 ( ( -LRB- cord-015021-pol2qm74 1546 12 + + CD cord-015021-pol2qm74 1546 13 SD sd NN cord-015021-pol2qm74 1546 14 ) ) -RRB- cord-015021-pol2qm74 1546 15 , , , cord-015021-pol2qm74 1546 16 was be VBD cord-015021-pol2qm74 1546 17 significantly significantly RB cord-015021-pol2qm74 1546 18 diminished diminish VBN cord-015021-pol2qm74 1546 19 in in IN cord-015021-pol2qm74 1546 20 the the DT cord-015021-pol2qm74 1546 21 transfused transfuse VBN cord-015021-pol2qm74 1546 22 animals animal NNS cord-015021-pol2qm74 1546 23 , , , cord-015021-pol2qm74 1546 24 as as IN cord-015021-pol2qm74 1546 25 compared compare VBN cord-015021-pol2qm74 1546 26 to to IN cord-015021-pol2qm74 1546 27 the the DT cord-015021-pol2qm74 1546 28 non non JJ cord-015021-pol2qm74 1546 29 - - JJ cord-015021-pol2qm74 1546 30 transfused transfused JJ cord-015021-pol2qm74 1546 31 animals animal NNS cord-015021-pol2qm74 1546 32 ( ( -LRB- cord-015021-pol2qm74 1546 33 ileum;day ileum;day NN cord-015021-pol2qm74 1546 34 3 3 CD cord-015021-pol2qm74 1546 35 ; ; : cord-015021-pol2qm74 1546 36 44-+8 44-+8 CD cord-015021-pol2qm74 1546 37 vs vs IN cord-015021-pol2qm74 1546 38 99 99 CD cord-015021-pol2qm74 1546 39 + + SYM cord-015021-pol2qm74 1546 40 7 7 CD cord-015021-pol2qm74 1546 41 , , , cord-015021-pol2qm74 1546 42 P<0.001 P<0.001 NNP cord-015021-pol2qm74 1546 43 ) ) -RRB- cord-015021-pol2qm74 1546 44 . . . cord-015021-pol2qm74 1547 1 Transfused transfuse VBN cord-015021-pol2qm74 1547 2 animals animal NNS cord-015021-pol2qm74 1547 3 pretreated pretreate VBD cord-015021-pol2qm74 1547 4 with with IN cord-015021-pol2qm74 1547 5 MTP MTP NNP cord-015021-pol2qm74 1547 6 - - HYPH cord-015021-pol2qm74 1547 7 PE PE NNP cord-015021-pol2qm74 1547 8 encapsulated encapsulate VBN cord-015021-pol2qm74 1547 9 Liposomes Liposomes NNP cord-015021-pol2qm74 1547 10 showed show VBD cord-015021-pol2qm74 1547 11 a a DT cord-015021-pol2qm74 1547 12 significant significant JJ cord-015021-pol2qm74 1547 13 improvement improvement NN cord-015021-pol2qm74 1547 14 of of IN cord-015021-pol2qm74 1547 15 their -PRON- PRP$ cord-015021-pol2qm74 1547 16 anastomotic anastomotic JJ cord-015021-pol2qm74 1547 17 bursting burst VBG cord-015021-pol2qm74 1547 18 pressure pressure NN cord-015021-pol2qm74 1547 19 ( ( -LRB- cord-015021-pol2qm74 1547 20 93 93 CD cord-015021-pol2qm74 1547 21 + + SYM cord-015021-pol2qm74 1547 22 9 9 CD cord-015021-pol2qm74 1547 23 , , , cord-015021-pol2qm74 1547 24 P<0.001 P<0.001 NNP cord-015021-pol2qm74 1547 25 vs vs IN cord-015021-pol2qm74 1547 26 transfusion transfusion NN cord-015021-pol2qm74 1547 27 ) ) -RRB- cord-015021-pol2qm74 1547 28 . . . cord-015021-pol2qm74 1548 1 Pretreatment pretreatment NN cord-015021-pol2qm74 1548 2 with with IN cord-015021-pol2qm74 1548 3 MTP MTP NNP cord-015021-pol2qm74 1548 4 - - HYPH cord-015021-pol2qm74 1548 5 PE PE NNP cord-015021-pol2qm74 1548 6 encapsulated encapsulate VBN cord-015021-pol2qm74 1548 7 Liposomes Liposomes NNP cord-015021-pol2qm74 1548 8 decreased decrease VBD cord-015021-pol2qm74 1548 9 significantly significantly RB cord-015021-pol2qm74 1548 10 the the DT cord-015021-pol2qm74 1548 11 incidence incidence NN cord-015021-pol2qm74 1548 12 of of IN cord-015021-pol2qm74 1548 13 anastomotic anastomotic JJ cord-015021-pol2qm74 1548 14 abscesses abscess NNS cord-015021-pol2qm74 1548 15 in in IN cord-015021-pol2qm74 1548 16 transfused transfuse VBN cord-015021-pol2qm74 1548 17 animals animal NNS cord-015021-pol2qm74 1548 18 ( ( -LRB- cord-015021-pol2qm74 1548 19 from from IN cord-015021-pol2qm74 1548 20 90 90 CD cord-015021-pol2qm74 1548 21 % % NN cord-015021-pol2qm74 1548 22 in in IN cord-015021-pol2qm74 1548 23 ileum ileum NN cord-015021-pol2qm74 1548 24 on on IN cord-015021-pol2qm74 1548 25 day day NN cord-015021-pol2qm74 1548 26 3 3 CD cord-015021-pol2qm74 1548 27 to to TO cord-015021-pol2qm74 1548 28 20 20 CD cord-015021-pol2qm74 1548 29 % % NN cord-015021-pol2qm74 1548 30 , , , cord-015021-pol2qm74 1548 31 P<0.001 P<0.001 NNP cord-015021-pol2qm74 1548 32 ) ) -RRB- cord-015021-pol2qm74 1548 33 . . . cord-015021-pol2qm74 1549 1 Conclusions Conclusions NNPS cord-015021-pol2qm74 1549 2 Preactivation Preactivation NNP cord-015021-pol2qm74 1549 3 of of IN cord-015021-pol2qm74 1549 4 regional regional JJ cord-015021-pol2qm74 1549 5 macrophges macrophge NNS cord-015021-pol2qm74 1549 6 by by IN cord-015021-pol2qm74 1549 7 intraperitoneal intraperitoneal JJ cord-015021-pol2qm74 1549 8 administration administration NN cord-015021-pol2qm74 1549 9 of of IN cord-015021-pol2qm74 1549 10 MTP MTP NNP cord-015021-pol2qm74 1549 11 - - HYPH cord-015021-pol2qm74 1549 12 PE PE NNP cord-015021-pol2qm74 1549 13 encapsulated encapsulate VBN cord-015021-pol2qm74 1549 14 Liposomes Liposomes NNP cord-015021-pol2qm74 1549 15 prevents prevent VBZ cord-015021-pol2qm74 1549 16 the the DT cord-015021-pol2qm74 1549 17 detrimental detrimental JJ cord-015021-pol2qm74 1549 18 effects effect NNS cord-015021-pol2qm74 1549 19 of of IN cord-015021-pol2qm74 1549 20 transfusions transfusion NNS cord-015021-pol2qm74 1549 21 on on IN cord-015021-pol2qm74 1549 22 anastomotic anastomotic JJ cord-015021-pol2qm74 1549 23 repair repair NN cord-015021-pol2qm74 1549 24 and and CC cord-015021-pol2qm74 1549 25 reduces reduce VBZ cord-015021-pol2qm74 1549 26 the the DT cord-015021-pol2qm74 1549 27 incidence incidence NN cord-015021-pol2qm74 1549 28 of of IN cord-015021-pol2qm74 1549 29 intraabdominal intraabdominal JJ cord-015021-pol2qm74 1549 30 sepsis sepsis NN cord-015021-pol2qm74 1549 31 . . . cord-015021-pol2qm74 1550 1 Academic Academic NNP cord-015021-pol2qm74 1550 2 Hospital Hospital NNP cord-015021-pol2qm74 1550 3 Nijmegen Nijmegen NNP cord-015021-pol2qm74 1550 4 , , , cord-015021-pol2qm74 1550 5 Dept Dept NNP cord-015021-pol2qm74 1550 6 of of IN cord-015021-pol2qm74 1550 7 General General NNP cord-015021-pol2qm74 1550 8 Surgery Surgery NNP cord-015021-pol2qm74 1550 9 , , , cord-015021-pol2qm74 1550 10 PB PB NNP cord-015021-pol2qm74 1550 11 910 910 CD cord-015021-pol2qm74 1550 12 I i NN cord-015021-pol2qm74 1550 13 , , , cord-015021-pol2qm74 1550 14 6500 6500 CD cord-015021-pol2qm74 1550 15 HB HB NNP cord-015021-pol2qm74 1550 16 Nijmegen Nijmegen NNP cord-015021-pol2qm74 1550 17 , , , cord-015021-pol2qm74 1550 18 The the DT cord-015021-pol2qm74 1550 19 Netherlands Netherlands NNP cord-015021-pol2qm74 1550 20 . . . cord-015021-pol2qm74 1551 1 LEUKEMIA LEUKEMIA NNP cord-015021-pol2qm74 1551 2 CELL cell NN cord-015021-pol2qm74 1551 3 LINE line NN cord-015021-pol2qm74 1551 4 , , , cord-015021-pol2qm74 1551 5 TEIP-1 TEIP-1 NNP cord-015021-pol2qm74 1551 6 . . . cord-015021-pol2qm74 1552 1 Robin Robin NNP cord-015021-pol2qm74 1552 2 S. S. NNP cord-015021-pol2qm74 1552 3 Wa Wa NNP cord-015021-pol2qm74 1552 4 , , , cord-015021-pol2qm74 1552 5 gner gner NNP cord-015021-pol2qm74 1552 6 * * NFP cord-015021-pol2qm74 1552 7 , , , cord-015021-pol2qm74 1552 8 Perry Perry NNP cord-015021-pol2qm74 1552 9 V. V. NNP cord-015021-pol2qm74 1552 10 Halushka Halushka NNP cord-015021-pol2qm74 1552 11 " " '' cord-015021-pol2qm74 1553 1 ~ ~ NFP cord-015021-pol2qm74 1553 2 , , , cord-015021-pol2qm74 1553 3 and and CC cord-015021-pol2qm74 1553 4 James James NNP cord-015021-pol2qm74 1553 5 A. a. NN cord-015021-pol2qm74 1553 6 Cook Cook NNP cord-015021-pol2qm74 1553 7 * * NFP cord-015021-pol2qm74 1553 8 , , , cord-015021-pol2qm74 1553 9 Departments Departments NNPS cord-015021-pol2qm74 1553 10 of of IN cord-015021-pol2qm74 1553 11 Physiology Physiology NNP cord-015021-pol2qm74 1553 12 , , , cord-015021-pol2qm74 1553 13 Pharmacology Pharmacology NNP cord-015021-pol2qm74 1553 14 " " `` cord-015021-pol2qm74 1553 15 l l NN cord-015021-pol2qm74 1553 16 " " '' cord-015021-pol2qm74 1553 17 and and CC cord-015021-pol2qm74 1553 18 Medicine Medicine NNP cord-015021-pol2qm74 1553 19 " " '' cord-015021-pol2qm74 1553 20 t t NNP cord-015021-pol2qm74 1553 21 , , , cord-015021-pol2qm74 1553 22 Medical Medical NNP cord-015021-pol2qm74 1553 23 University University NNP cord-015021-pol2qm74 1553 24 of of IN cord-015021-pol2qm74 1553 25 South South NNP cord-015021-pol2qm74 1553 26 Carolina Carolina NNP cord-015021-pol2qm74 1553 27 , , , cord-015021-pol2qm74 1553 28 Charleston Charleston NNP cord-015021-pol2qm74 1553 29 , , , cord-015021-pol2qm74 1553 30 S.C. South Carolina NNP cord-015021-pol2qm74 1553 31 29425 29425 CD cord-015021-pol2qm74 1553 32 . . . cord-015021-pol2qm74 1554 1 Adherence adherence NN cord-015021-pol2qm74 1554 2 of of IN cord-015021-pol2qm74 1554 3 monoeytes monoeyte NNS cord-015021-pol2qm74 1554 4 to to TO cord-015021-pol2qm74 1554 5 endothelium endothelium NN cord-015021-pol2qm74 1554 6 and and CC cord-015021-pol2qm74 1554 7 extracella extracella NNP cord-015021-pol2qm74 1554 8 / / SYM cord-015021-pol2qm74 1554 9 ar ar NNP cord-015021-pol2qm74 1554 10 matrix matrix NN cord-015021-pol2qm74 1554 11 proteins protein NNS cord-015021-pol2qm74 1554 12 is be VBZ cord-015021-pol2qm74 1554 13 essential essential JJ cord-015021-pol2qm74 1554 14 for for IN cord-015021-pol2qm74 1554 15 accumulation accumulation NN cord-015021-pol2qm74 1554 16 at at IN cord-015021-pol2qm74 1554 17 sites site NNS cord-015021-pol2qm74 1554 18 of of IN cord-015021-pol2qm74 1554 19 inflammation inflammation NN cord-015021-pol2qm74 1554 20 . . . cord-015021-pol2qm74 1555 1 TXA2 TXA2 NNP cord-015021-pol2qm74 1555 2 , , , cord-015021-pol2qm74 1555 3 an an DT cord-015021-pol2qm74 1555 4 arachidonic arachidonic JJ cord-015021-pol2qm74 1555 5 acid acid NN cord-015021-pol2qm74 1555 6 metabolite metabolite NN cord-015021-pol2qm74 1555 7 , , , cord-015021-pol2qm74 1555 8 inhibits inhibit VBZ cord-015021-pol2qm74 1555 9 human human JJ cord-015021-pol2qm74 1555 10 monocyte monocyte NNP cord-015021-pol2qm74 1555 11 chemotactic chemotactic JJ cord-015021-pol2qm74 1555 12 responses response NNS cord-015021-pol2qm74 1555 13 suggesting suggest VBG cord-015021-pol2qm74 1555 14 that that IN cord-015021-pol2qm74 1555 15 TXA TXA NNP cord-015021-pol2qm74 1555 16 2 2 CD cord-015021-pol2qm74 1555 17 may may MD cord-015021-pol2qm74 1555 18 alter alter VB cord-015021-pol2qm74 1555 19 monocyte monocyte JJ cord-015021-pol2qm74 1555 20 adhesiveness adhesiveness NN cord-015021-pol2qm74 1555 21 . . . cord-015021-pol2qm74 1556 1 We -PRON- PRP cord-015021-pol2qm74 1556 2 selected select VBD cord-015021-pol2qm74 1556 3 the the DT cord-015021-pol2qm74 1556 4 THP-1 THP-1 NNP cord-015021-pol2qm74 1556 5 cell cell NN cord-015021-pol2qm74 1556 6 line line NN cord-015021-pol2qm74 1556 7 , , , cord-015021-pol2qm74 1556 8 a a DT cord-015021-pol2qm74 1556 9 human human JJ cord-015021-pol2qm74 1556 10 monocytic monocytic JJ cord-015021-pol2qm74 1556 11 leukemia leukemia NN cord-015021-pol2qm74 1556 12 cell cell NN cord-015021-pol2qm74 1556 13 line line NN cord-015021-pol2qm74 1556 14 to to TO cord-015021-pol2qm74 1556 15 further further RB cord-015021-pol2qm74 1556 16 investigate investigate VB cord-015021-pol2qm74 1556 17 the the DT cord-015021-pol2qm74 1556 18 effect effect NN cord-015021-pol2qm74 1556 19 of of IN cord-015021-pol2qm74 1556 20 TXA TXA NNP cord-015021-pol2qm74 1556 21 2 2 CD cord-015021-pol2qm74 1556 22 on on IN cord-015021-pol2qm74 1556 23 adhesion adhesion NN cord-015021-pol2qm74 1556 24 . . . cord-015021-pol2qm74 1557 1 We -PRON- PRP cord-015021-pol2qm74 1557 2 tested test VBD cord-015021-pol2qm74 1557 3 the the DT cord-015021-pol2qm74 1557 4 hypothesis hypothesis NN cord-015021-pol2qm74 1557 5 that that IN cord-015021-pol2qm74 1557 6 TXA TXA NNP cord-015021-pol2qm74 1557 7 2 2 CD cord-015021-pol2qm74 1557 8 alters alter VBZ cord-015021-pol2qm74 1557 9 LPSinduced lpsinduced JJ cord-015021-pol2qm74 1557 10 adhesion adhesion NN cord-015021-pol2qm74 1557 11 of of IN cord-015021-pol2qm74 1557 12 THP-1 THP-1 NNP cord-015021-pol2qm74 1557 13 cells cell NNS cord-015021-pol2qm74 1557 14 and and CC cord-015021-pol2qm74 1557 15 that that IN cord-015021-pol2qm74 1557 16 TXA TXA NNP cord-015021-pol2qm74 1557 17 2 2 CD cord-015021-pol2qm74 1557 18 exerts exert VBZ cord-015021-pol2qm74 1557 19 its -PRON- PRP$ cord-015021-pol2qm74 1557 20 effect effect NN cord-015021-pol2qm74 1557 21 on on IN cord-015021-pol2qm74 1557 22 adhesion adhesion NN cord-015021-pol2qm74 1557 23 via via IN cord-015021-pol2qm74 1557 24 a a DT cord-015021-pol2qm74 1557 25 cAMP camp NN cord-015021-pol2qm74 1557 26 dependent dependent JJ cord-015021-pol2qm74 1557 27 mechanism mechanism NN cord-015021-pol2qm74 1557 28 . . . cord-015021-pol2qm74 1558 1 THP THP NNP cord-015021-pol2qm74 1558 2 - - HYPH cord-015021-pol2qm74 1558 3 I -PRON- PRP cord-015021-pol2qm74 1558 4 cells cell NNS cord-015021-pol2qm74 1558 5 were be VBD cord-015021-pol2qm74 1558 6 exposed expose VBN cord-015021-pol2qm74 1558 7 to to IN cord-015021-pol2qm74 1558 8 S. S. NNP cord-015021-pol2qm74 1558 9 enteritidis enteritidis NN cord-015021-pol2qm74 1558 10 endotoxin endotoxin NN cord-015021-pol2qm74 1558 11 ( ( -LRB- cord-015021-pol2qm74 1558 12 lp.g lp.g NNP cord-015021-pol2qm74 1558 13 / / SYM cord-015021-pol2qm74 1558 14 ml ml NN cord-015021-pol2qm74 1558 15 ) ) -RRB- cord-015021-pol2qm74 1559 1 _ _ NNP cord-015021-pol2qm74 1560 1 + + CC cord-015021-pol2qm74 1560 2 the the DT cord-015021-pol2qm74 1560 3 cyelooxygenase cyelooxygenase JJ cord-015021-pol2qm74 1560 4 inhibitor inhibitor NN cord-015021-pol2qm74 1560 5 lndomethacin lndomethacin NNS cord-015021-pol2qm74 1560 6 ( ( -LRB- cord-015021-pol2qm74 1560 7 IN in IN cord-015021-pol2qm74 1560 8 ) ) -RRB- cord-015021-pol2qm74 1560 9 , , , cord-015021-pol2qm74 1560 10 the the DT cord-015021-pol2qm74 1560 11 TXA TXA NNP cord-015021-pol2qm74 1560 12 2 2 CD cord-015021-pol2qm74 1560 13 mimetic mimetic NN cord-015021-pol2qm74 1560 14 I I NNP cord-015021-pol2qm74 1560 15 - - HYPH cord-015021-pol2qm74 1560 16 BOP BOP NNP cord-015021-pol2qm74 1560 17 ( ( -LRB- cord-015021-pol2qm74 1560 18 0.11.tM 0.11.tm CD cord-015021-pol2qm74 1560 19 , , , cord-015021-pol2qm74 1560 20 ) ) -RRB- cord-015021-pol2qm74 1560 21 or or CC cord-015021-pol2qm74 1560 22 TXA TXA NNP cord-015021-pol2qm74 1560 23 2 2 CD cord-015021-pol2qm74 1560 24 receptor receptor NN cord-015021-pol2qm74 1560 25 antagonists antagonist NNS cord-015021-pol2qm74 1561 1 BMS180291 BMS180291 NNP cord-015021-pol2qm74 1561 2 and and CC cord-015021-pol2qm74 1561 3 L657925 L657925 NNP cord-015021-pol2qm74 1561 4 ( ( -LRB- cord-015021-pol2qm74 1561 5 10~M 10~m CD cord-015021-pol2qm74 1561 6 ) ) -RRB- cord-015021-pol2qm74 1561 7 . . . cord-015021-pol2qm74 1562 1 Cells cell NNS cord-015021-pol2qm74 1562 2 were be VBD cord-015021-pol2qm74 1562 3 allowed allow VBN cord-015021-pol2qm74 1562 4 to to TO cord-015021-pol2qm74 1562 5 adhere adhere VB cord-015021-pol2qm74 1562 6 for for IN cord-015021-pol2qm74 1562 7 24 24 CD cord-015021-pol2qm74 1562 8 hours hour NNS cord-015021-pol2qm74 1562 9 and and CC cord-015021-pol2qm74 1562 10 adherent adherent JJ cord-015021-pol2qm74 1562 11 protein/ protein/ XX cord-015021-pol2qm74 1563 1 well well UH cord-015021-pol2qm74 1563 2 was be VBD cord-015021-pol2qm74 1563 3 determined determine VBN cord-015021-pol2qm74 1563 4 . . . cord-015021-pol2qm74 1564 1 LPS LPS NNP cord-015021-pol2qm74 1564 2 - - HYPH cord-015021-pol2qm74 1564 3 induced induce VBN cord-015021-pol2qm74 1564 4 a a DT cord-015021-pol2qm74 1564 5 significant significant JJ cord-015021-pol2qm74 1564 6 ( ( -LRB- cord-015021-pol2qm74 1564 7 p<0.05;n=7 p<0.05;n=7 NN cord-015021-pol2qm74 1564 8 ) ) -RRB- cord-015021-pol2qm74 1564 9 increase increase VB cord-015021-pol2qm74 1564 10 in in IN cord-015021-pol2qm74 1564 11 adherence adherence NN cord-015021-pol2qm74 1564 12 of of IN cord-015021-pol2qm74 1564 13 THP-1 THP-1 NNP cord-015021-pol2qm74 1564 14 cells cell NNS cord-015021-pol2qm74 1564 15 ( ( -LRB- cord-015021-pol2qm74 1564 16 Basal Basal NNP cord-015021-pol2qm74 1564 17 , , , cord-015021-pol2qm74 1564 18 2.4 2.4 CD cord-015021-pol2qm74 1564 19 + + SYM cord-015021-pol2qm74 1564 20 0.85gg 0.85gg CD cord-015021-pol2qm74 1564 21 protein/ protein/ ADD cord-015021-pol2qm74 1565 1 well well UH cord-015021-pol2qm74 1565 2 ; ; : cord-015021-pol2qm74 1565 3 LPS LPS NNP cord-015021-pol2qm74 1565 4 , , , cord-015021-pol2qm74 1566 1 20.4+_6.0p.g 20.4+_6.0p.g CD cord-015021-pol2qm74 1566 2 protein protein NN cord-015021-pol2qm74 1566 3 / / SYM cord-015021-pol2qm74 1566 4 well well RB cord-015021-pol2qm74 1566 5 ) ) -RRB- cord-015021-pol2qm74 1566 6 . . . cord-015021-pol2qm74 1567 1 The the DT cord-015021-pol2qm74 1567 2 amino amino NN cord-015021-pol2qm74 1567 3 acid acid NN cord-015021-pol2qm74 1567 4 glutamine glutamine NN cord-015021-pol2qm74 1567 5 is be VBZ cord-015021-pol2qm74 1567 6 an an DT cord-015021-pol2qm74 1567 7 essential essential JJ cord-015021-pol2qm74 1567 8 compound compound NN cord-015021-pol2qm74 1567 9 for for IN cord-015021-pol2qm74 1567 10 synthesis synthesis NN cord-015021-pol2qm74 1567 11 of of IN cord-015021-pol2qm74 1567 12 purine purine NNP cord-015021-pol2qm74 1567 13 and and CC cord-015021-pol2qm74 1567 14 pyrimidine pyrimidine JJ cord-015021-pol2qm74 1567 15 basis basis NN cord-015021-pol2qm74 1567 16 and and CC cord-015021-pol2qm74 1567 17 therefore therefore RB cord-015021-pol2qm74 1567 18 necessary necessary JJ cord-015021-pol2qm74 1567 19 for for IN cord-015021-pol2qm74 1567 20 RNA RNA NNP cord-015021-pol2qm74 1567 21 - - : cord-015021-pol2qm74 1567 22 and and CC cord-015021-pol2qm74 1567 23 DNA dna NN cord-015021-pol2qm74 1567 24 synthesis synthesis NN cord-015021-pol2qm74 1567 25 . . . cord-015021-pol2qm74 1568 1 In in IN cord-015021-pol2qm74 1568 2 human human JJ cord-015021-pol2qm74 1568 3 plasma plasma NN cord-015021-pol2qm74 1568 4 the the DT cord-015021-pol2qm74 1568 5 concentration concentration NN cord-015021-pol2qm74 1568 6 of of IN cord-015021-pol2qm74 1568 7 glutamine glutamine NN cord-015021-pol2qm74 1568 8 is be VBZ cord-015021-pol2qm74 1568 9 between between IN cord-015021-pol2qm74 1568 10 0.5 0.5 CD cord-015021-pol2qm74 1568 11 -0.6 -0.6 CD cord-015021-pol2qm74 1568 12 mM mm NN cord-015021-pol2qm74 1568 13 , , , cord-015021-pol2qm74 1568 14 and and CC cord-015021-pol2qm74 1568 15 is be VBZ cord-015021-pol2qm74 1568 16 reduced reduce VBN cord-015021-pol2qm74 1568 17 in in IN cord-015021-pol2qm74 1568 18 septic septic JJ cord-015021-pol2qm74 1568 19 patients patient NNS cord-015021-pol2qm74 1568 20 up up RP cord-015021-pol2qm74 1568 21 to to TO cord-015021-pol2qm74 1568 22 80 80 CD cord-015021-pol2qm74 1568 23 % % NN cord-015021-pol2qm74 1568 24 ( ( -LRB- cord-015021-pol2qm74 1568 25 0.1 0.1 CD cord-015021-pol2qm74 1568 26 -0.2 -0.2 SYM cord-015021-pol2qm74 1568 27 mM mm CD cord-015021-pol2qm74 1568 28 ) ) -RRB- cord-015021-pol2qm74 1568 29 . . . cord-015021-pol2qm74 1569 1 Monocytes monocyte NNS cord-015021-pol2qm74 1569 2 play play VBP cord-015021-pol2qm74 1569 3 a a DT cord-015021-pol2qm74 1569 4 central central JJ cord-015021-pol2qm74 1569 5 part part NN cord-015021-pol2qm74 1569 6 in in IN cord-015021-pol2qm74 1569 7 the the DT cord-015021-pol2qm74 1569 8 inunune inunune JJ cord-015021-pol2qm74 1569 9 system system NN cord-015021-pol2qm74 1569 10 and and CC cord-015021-pol2qm74 1569 11 it -PRON- PRP cord-015021-pol2qm74 1569 12 was be VBD cord-015021-pol2qm74 1569 13 of of IN cord-015021-pol2qm74 1569 14 interest interest NN cord-015021-pol2qm74 1569 15 , , , cord-015021-pol2qm74 1569 16 whether whether IN cord-015021-pol2qm74 1569 17 glutamine glutamine NN cord-015021-pol2qm74 1569 18 is be VBZ cord-015021-pol2qm74 1569 19 involved involve VBN cord-015021-pol2qm74 1569 20 in in IN cord-015021-pol2qm74 1569 21 the the DT cord-015021-pol2qm74 1569 22 modulation modulation NN cord-015021-pol2qm74 1569 23 of of IN cord-015021-pol2qm74 1569 24 cell cell NN cord-015021-pol2qm74 1569 25 surface surface NN cord-015021-pol2qm74 1569 26 markers marker NNS cord-015021-pol2qm74 1569 27 and and CC cord-015021-pol2qm74 1569 28 phagocytosis phagocytosis NN cord-015021-pol2qm74 1569 29 of of IN cord-015021-pol2qm74 1569 30 these these DT cord-015021-pol2qm74 1569 31 cells cell NNS cord-015021-pol2qm74 1569 32 . . . cord-015021-pol2qm74 1570 1 Human human JJ cord-015021-pol2qm74 1570 2 peripheral peripheral JJ cord-015021-pol2qm74 1570 3 blood blood NN cord-015021-pol2qm74 1570 4 mononuclear mononuclear FW cord-015021-pol2qm74 1570 5 ceils ceil NNS cord-015021-pol2qm74 1570 6 were be VBD cord-015021-pol2qm74 1570 7 obtained obtain VBN cord-015021-pol2qm74 1570 8 from from IN cord-015021-pol2qm74 1570 9 500 500 CD cord-015021-pol2qm74 1570 10 ml ml XX cord-015021-pol2qm74 1570 11 heparinized heparinize VBN cord-015021-pol2qm74 1570 12 blood blood NN cord-015021-pol2qm74 1570 13 of of IN cord-015021-pol2qm74 1570 14 apparently apparently RB cord-015021-pol2qm74 1570 15 healthy healthy JJ cord-015021-pol2qm74 1570 16 donors donor NNS cord-015021-pol2qm74 1570 17 by by IN cord-015021-pol2qm74 1570 18 Ficoll Ficoll NNP cord-015021-pol2qm74 1570 19 - - HYPH cord-015021-pol2qm74 1570 20 Paque paque JJ cord-015021-pol2qm74 1570 21 density density NN cord-015021-pol2qm74 1570 22 gradient gradient NN cord-015021-pol2qm74 1570 23 and and CC cord-015021-pol2qm74 1570 24 isolated isolate VBN cord-015021-pol2qm74 1570 25 by by IN cord-015021-pol2qm74 1570 26 counterflow counterflow NN cord-015021-pol2qm74 1570 27 elutriation elutriation NN cord-015021-pol2qm74 1570 28 . . . cord-015021-pol2qm74 1571 1 The the DT cord-015021-pol2qm74 1571 2 puritiy puritiy NNS cord-015021-pol2qm74 1571 3 was be VBD cord-015021-pol2qm74 1571 4 more more JJR cord-015021-pol2qm74 1571 5 than than IN cord-015021-pol2qm74 1571 6 90 90 CD cord-015021-pol2qm74 1571 7 % % NN cord-015021-pol2qm74 1571 8 . . . cord-015021-pol2qm74 1572 1 Subsequently subsequently RB cord-015021-pol2qm74 1572 2 cells cell NNS cord-015021-pol2qm74 1572 3 were be VBD cord-015021-pol2qm74 1572 4 cultured culture VBN cord-015021-pol2qm74 1572 5 in in IN cord-015021-pol2qm74 1572 6 phenolred phenolre VBN cord-015021-pol2qm74 1572 7 - - HYPH cord-015021-pol2qm74 1572 8 free free JJ cord-015021-pol2qm74 1572 9 RPMI RPMI NNP cord-015021-pol2qm74 1572 10 1640 1640 CD cord-015021-pol2qm74 1572 11 medium medium NN cord-015021-pol2qm74 1572 12 with with IN cord-015021-pol2qm74 1572 13 various various JJ cord-015021-pol2qm74 1572 14 concentrations concentration NNS cord-015021-pol2qm74 1572 15 of of IN cord-015021-pol2qm74 1572 16 glutamine glutamine NN cord-015021-pol2qm74 1572 17 ( ( -LRB- cord-015021-pol2qm74 1572 18 0.05 0.05 CD cord-015021-pol2qm74 1572 19 , , , cord-015021-pol2qm74 1572 20 0.1 0.1 CD cord-015021-pol2qm74 1572 21 , , , cord-015021-pol2qm74 1572 22 0.2 0.2 CD cord-015021-pol2qm74 1572 23 , , , cord-015021-pol2qm74 1572 24 0.3 0.3 CD cord-015021-pol2qm74 1572 25 , , , cord-015021-pol2qm74 1572 26 0.6 0.6 CD cord-015021-pol2qm74 1572 27 , , , cord-015021-pol2qm74 1572 28 1 1 CD cord-015021-pol2qm74 1572 29 , , , cord-015021-pol2qm74 1572 30 2 2 CD cord-015021-pol2qm74 1572 31 mM mm CD cord-015021-pol2qm74 1572 32 ) ) -RRB- cord-015021-pol2qm74 1572 33 in in IN cord-015021-pol2qm74 1572 34 teflon teflon NN cord-015021-pol2qm74 1572 35 - - HYPH cord-015021-pol2qm74 1572 36 fluorinated fluorinate VBN cord-015021-pol2qm74 1572 37 ethylene ethylene NN cord-015021-pol2qm74 1572 38 propylene propylene NN cord-015021-pol2qm74 1572 39 bottles bottle NNS cord-015021-pol2qm74 1572 40 to to TO cord-015021-pol2qm74 1572 41 exclude exclude VB cord-015021-pol2qm74 1572 42 cell cell NN cord-015021-pol2qm74 1572 43 adhesion adhesion NN cord-015021-pol2qm74 1572 44 and and CC cord-015021-pol2qm74 1572 45 possible possible JJ cord-015021-pol2qm74 1572 46 cell cell NN cord-015021-pol2qm74 1572 47 activation activation NN cord-015021-pol2qm74 1572 48 . . . cord-015021-pol2qm74 1573 1 Aider Aider NNP cord-015021-pol2qm74 1573 2 seven seven CD cord-015021-pol2qm74 1573 3 days day NNS cord-015021-pol2qm74 1573 4 culture culture NN cord-015021-pol2qm74 1573 5 , , , cord-015021-pol2qm74 1573 6 cell cell NN cord-015021-pol2qm74 1573 7 viabilty viabilty NN cord-015021-pol2qm74 1573 8 was be VBD cord-015021-pol2qm74 1573 9 determined determine VBN cord-015021-pol2qm74 1573 10 by by IN cord-015021-pol2qm74 1573 11 trepan trepan NNP cord-015021-pol2qm74 1573 12 blue blue JJ cord-015021-pol2qm74 1573 13 exclusion exclusion NN cord-015021-pol2qm74 1573 14 and and CC cord-015021-pol2qm74 1573 15 varied vary VBN cord-015021-pol2qm74 1573 16 between between IN cord-015021-pol2qm74 1573 17 70 70 CD cord-015021-pol2qm74 1573 18 and and CC cord-015021-pol2qm74 1573 19 90 90 CD cord-015021-pol2qm74 1573 20 % % NN cord-015021-pol2qm74 1573 21 , , , cord-015021-pol2qm74 1573 22 independent independent JJ cord-015021-pol2qm74 1573 23 of of IN cord-015021-pol2qm74 1573 24 glutamine glutamine NN cord-015021-pol2qm74 1573 25 concentrations concentration NNS cord-015021-pol2qm74 1573 26 . . . cord-015021-pol2qm74 1574 1 Cell cell NN cord-015021-pol2qm74 1574 2 surface surface NN cord-015021-pol2qm74 1574 3 markers marker NNS cord-015021-pol2qm74 1574 4 were be VBD cord-015021-pol2qm74 1574 5 detected detect VBN cord-015021-pol2qm74 1574 6 by by IN cord-015021-pol2qm74 1574 7 flow flow NN cord-015021-pol2qm74 1574 8 cytometry cytometry NN cord-015021-pol2qm74 1574 9 , , , cord-015021-pol2qm74 1574 10 noaspecifie noaspecifie NNP cord-015021-pol2qm74 1574 11 phagoeytosis phagoeytosis NNP cord-015021-pol2qm74 1574 12 was be VBD cord-015021-pol2qm74 1574 13 measured measure VBN cord-015021-pol2qm74 1574 14 with with IN cord-015021-pol2qm74 1574 15 latex latex NN cord-015021-pol2qm74 1574 16 beads bead NNS cord-015021-pol2qm74 1574 17 and and CC cord-015021-pol2qm74 1574 18 specific specific JJ cord-015021-pol2qm74 1574 19 phagocytosis phagocytosis NN cord-015021-pol2qm74 1574 20 with with IN cord-015021-pol2qm74 1574 21 opsonizied opsonizied JJ cord-015021-pol2qm74 1574 22 E.eoli E.eoli NNS cord-015021-pol2qm74 1574 23 using use VBG cord-015021-pol2qm74 1574 24 a a DT cord-015021-pol2qm74 1574 25 FACScan facscan NN cord-015021-pol2qm74 1574 26 . . . cord-015021-pol2qm74 1575 1 Lower low JJR cord-015021-pol2qm74 1575 2 concentrations concentration NNS cord-015021-pol2qm74 1575 3 of of IN cord-015021-pol2qm74 1575 4 glutamine glutamine NN cord-015021-pol2qm74 1575 5 decreased decrease VBD cord-015021-pol2qm74 1575 6 the the DT cord-015021-pol2qm74 1575 7 expression expression NN cord-015021-pol2qm74 1575 8 of of IN cord-015021-pol2qm74 1575 9 HLA HLA NNP cord-015021-pol2qm74 1575 10 - - HYPH cord-015021-pol2qm74 1575 11 DR DR NNP cord-015021-pol2qm74 1575 12 and and CC cord-015021-pol2qm74 1575 13 ICAM-1 ICAM-1 NNP cord-015021-pol2qm74 1575 14 / / SYM cord-015021-pol2qm74 1575 15 CD54 CD54 NNP cord-015021-pol2qm74 1575 16 on on IN cord-015021-pol2qm74 1575 17 monocytes monocyte NNS cord-015021-pol2qm74 1575 18 in in IN cord-015021-pol2qm74 1575 19 a a DT cord-015021-pol2qm74 1575 20 dose dose NN cord-015021-pol2qm74 1575 21 - - HYPH cord-015021-pol2qm74 1575 22 dependent dependent JJ cord-015021-pol2qm74 1575 23 manner manner NN cord-015021-pol2qm74 1575 24 . . . cord-015021-pol2qm74 1576 1 The the DT cord-015021-pol2qm74 1576 2 receptor receptor NN cord-015021-pol2qm74 1576 3 for for IN cord-015021-pol2qm74 1576 4 Fc'/RUCD64 Fc'/RUCD64 NNP cord-015021-pol2qm74 1576 5 as as RB cord-015021-pol2qm74 1576 6 well well RB cord-015021-pol2qm74 1576 7 as as IN cord-015021-pol2qm74 1576 8 the the DT cord-015021-pol2qm74 1576 9 receptors receptor NNS cord-015021-pol2qm74 1576 10 for for IN cord-015021-pol2qm74 1576 11 complement complement JJ cord-015021-pol2qm74 1576 12 CR3 CR3 NNP cord-015021-pol2qm74 1576 13 / / SYM cord-015021-pol2qm74 1576 14 CDllb CDllb NNP cord-015021-pol2qm74 1576 15 and and CC cord-015021-pol2qm74 1576 16 CR4 CR4 NNP cord-015021-pol2qm74 1576 17 / / SYM cord-015021-pol2qm74 1576 18 CDllc CDllc NNP cord-015021-pol2qm74 1576 19 were be VBD cord-015021-pol2qm74 1576 20 down down RB cord-015021-pol2qm74 1576 21 - - HYPH cord-015021-pol2qm74 1576 22 regulated regulate VBN cord-015021-pol2qm74 1576 23 . . . cord-015021-pol2qm74 1577 1 CR1 CR1 NNP cord-015021-pol2qm74 1577 2 / / SYM cord-015021-pol2qm74 1577 3 CD35 CD35 NNP cord-015021-pol2qm74 1577 4 which which WDT cord-015021-pol2qm74 1577 5 is be VBZ cord-015021-pol2qm74 1577 6 only only RB cord-015021-pol2qm74 1577 7 slightly slightly RB cord-015021-pol2qm74 1577 8 expressed express VBN cord-015021-pol2qm74 1577 9 on on IN cord-015021-pol2qm74 1577 10 monocytes monocyte NNS cord-015021-pol2qm74 1577 11 was be VBD cord-015021-pol2qm74 1577 12 not not RB cord-015021-pol2qm74 1577 13 influenced influence VBN cord-015021-pol2qm74 1577 14 . . . cord-015021-pol2qm74 1578 1 Furthermore furthermore RB cord-015021-pol2qm74 1578 2 , , , cord-015021-pol2qm74 1578 3 no no DT cord-015021-pol2qm74 1578 4 effects effect NNS cord-015021-pol2qm74 1578 5 on on IN cord-015021-pol2qm74 1578 6 the the DT cord-015021-pol2qm74 1578 7 expression expression NN cord-015021-pol2qm74 1578 8 of of IN cord-015021-pol2qm74 1578 9 CDI4 CDI4 NNP cord-015021-pol2qm74 1578 10 , , , cord-015021-pol2qm74 1578 11 the the DT cord-015021-pol2qm74 1578 12 receptor receptor NN cord-015021-pol2qm74 1578 13 for for IN cord-015021-pol2qm74 1578 14 transferrin transferrin NN cord-015021-pol2qm74 1578 15 CD71 CD71 NNP cord-015021-pol2qm74 1578 16 and and CC cord-015021-pol2qm74 1578 17 Fc'fRIII Fc'fRIII NNP cord-015021-pol2qm74 1578 18 / / SYM cord-015021-pol2qm74 1578 19 CD16 CD16 NNP cord-015021-pol2qm74 1578 20 were be VBD cord-015021-pol2qm74 1578 21 seen see VBN cord-015021-pol2qm74 1578 22 . . . cord-015021-pol2qm74 1579 1 Our -PRON- PRP$ cord-015021-pol2qm74 1579 2 data datum NNS cord-015021-pol2qm74 1579 3 indicate indicate VBP cord-015021-pol2qm74 1579 4 , , , cord-015021-pol2qm74 1579 5 that that IN cord-015021-pol2qm74 1579 6 lower low JJR cord-015021-pol2qm74 1579 7 concentrations concentration NNS cord-015021-pol2qm74 1579 8 of of IN cord-015021-pol2qm74 1579 9 glutamme glutamme NN cord-015021-pol2qm74 1579 10 influence influence VBP cord-015021-pol2qm74 1579 11 the the DT cord-015021-pol2qm74 1579 12 phenotype phenotype NN cord-015021-pol2qm74 1579 13 of of IN cord-015021-pol2qm74 1579 14 monocytes monocyte NNS cord-015021-pol2qm74 1579 15 . . . cord-015021-pol2qm74 1580 1 We -PRON- PRP cord-015021-pol2qm74 1580 2 are be VBP cord-015021-pol2qm74 1580 3 now now RB cord-015021-pol2qm74 1580 4 interested interested JJ cord-015021-pol2qm74 1580 5 to to TO cord-015021-pol2qm74 1580 6 study study VB cord-015021-pol2qm74 1580 7 whether whether IN cord-015021-pol2qm74 1580 8 glutmnine glutmnine NNP cord-015021-pol2qm74 1580 9 influences influence NNS cord-015021-pol2qm74 1580 10 non non JJ cord-015021-pol2qm74 1580 11 - - JJ cord-015021-pol2qm74 1580 12 specific specific JJ cord-015021-pol2qm74 1580 13 phagocytosis phagocytosis NN cord-015021-pol2qm74 1580 14 , , , cord-015021-pol2qm74 1580 15 or or CC cord-015021-pol2qm74 1580 16 whether whether IN cord-015021-pol2qm74 1580 17 specific specific JJ cord-015021-pol2qm74 1580 18 phagocytosis phagocytosis NN cord-015021-pol2qm74 1580 19 correlates correlate VBZ cord-015021-pol2qm74 1580 20 with with IN cord-015021-pol2qm74 1580 21 the the DT cord-015021-pol2qm74 1580 22 decreased decreased JJ cord-015021-pol2qm74 1580 23 expression expression NN cord-015021-pol2qm74 1580 24 of of IN cord-015021-pol2qm74 1580 25 Fc'/R Fc'/R NNS cord-015021-pol2qm74 1580 26 and and CC cord-015021-pol2qm74 1580 27 complement complement VB cord-015021-pol2qm74 1580 28 receptors receptor NNS cord-015021-pol2qm74 1580 29 . . . cord-015021-pol2qm74 1581 1 We -PRON- PRP cord-015021-pol2qm74 1581 2 investigated investigate VBD cord-015021-pol2qm74 1581 3 immunologically immunologically RB cord-015021-pol2qm74 1581 4 more more JJR cord-015021-pol2qm74 1581 5 than than IN cord-015021-pol2qm74 1581 6 300 300 CD cord-015021-pol2qm74 1581 7 patients patient NNS cord-015021-pol2qm74 1581 8 who who WP cord-015021-pol2qm74 1581 9 were be VBD cord-015021-pol2qm74 1581 10 admitted admit VBN cord-015021-pol2qm74 1581 11 to to IN cord-015021-pol2qm74 1581 12 ICU ICU NNP cord-015021-pol2qm74 1581 13 because because IN cord-015021-pol2qm74 1581 14 septic septic JJ cord-015021-pol2qm74 1581 15 syndrom syndrom NN cord-015021-pol2qm74 1581 16 during during IN cord-015021-pol2qm74 1581 17 the the DT cord-015021-pol2qm74 1581 18 last last JJ cord-015021-pol2qm74 1581 19 four four CD cord-015021-pol2qm74 1581 20 years year NNS cord-015021-pol2qm74 1581 21 . . . cord-015021-pol2qm74 1582 1 Patients patient NNS cord-015021-pol2qm74 1582 2 were be VBD cord-015021-pol2qm74 1582 3 immunologically immunologically RB cord-015021-pol2qm74 1582 4 followed follow VBN cord-015021-pol2qm74 1582 5 up up RP cord-015021-pol2qm74 1582 6 2 2 CD cord-015021-pol2qm74 1582 7 - - SYM cord-015021-pol2qm74 1582 8 3 3 CD cord-015021-pol2qm74 1582 9 times time NNS cord-015021-pol2qm74 1582 10 per per IN cord-015021-pol2qm74 1582 11 week week NN cord-015021-pol2qm74 1582 12 until until IN cord-015021-pol2qm74 1582 13 release release NN cord-015021-pol2qm74 1582 14 from from IN cord-015021-pol2qm74 1582 15 ICU ICU NNP cord-015021-pol2qm74 1582 16 . . . cord-015021-pol2qm74 1583 1 The the DT cord-015021-pol2qm74 1583 2 expression expression NN cord-015021-pol2qm74 1583 3 of of IN cord-015021-pol2qm74 1583 4 HLA HLA NNP cord-015021-pol2qm74 1583 5 - - HYPH cord-015021-pol2qm74 1583 6 DR DR NNP cord-015021-pol2qm74 1583 7 antigen antigen NN cord-015021-pol2qm74 1583 8 on on IN cord-015021-pol2qm74 1583 9 monocytes monocyte NNS cord-015021-pol2qm74 1583 10 turned turn VBD cord-015021-pol2qm74 1583 11 out out RP cord-015021-pol2qm74 1583 12 to to TO cord-015021-pol2qm74 1583 13 be be VB cord-015021-pol2qm74 1583 14 the the DT cord-015021-pol2qm74 1583 15 best good JJS cord-015021-pol2qm74 1583 16 prognostic prognostic JJ cord-015021-pol2qm74 1583 17 parameter parameter NN cord-015021-pol2qm74 1583 18 . . . cord-015021-pol2qm74 1584 1 The the DT cord-015021-pol2qm74 1584 2 persistence persistence NN cord-015021-pol2qm74 1584 3 ( ( -LRB- cord-015021-pol2qm74 1584 4 > > NFP cord-015021-pol2qm74 1584 5 5 5 CD cord-015021-pol2qm74 1584 6 days day NNS cord-015021-pol2qm74 1584 7 ) ) -RRB- cord-015021-pol2qm74 1584 8 of of IN cord-015021-pol2qm74 1584 9 low low JJ cord-015021-pol2qm74 1584 10 HLA HLA NNP cord-015021-pol2qm74 1584 11 - - HYPH cord-015021-pol2qm74 1584 12 DR DR NNP cord-015021-pol2qm74 1584 13 expression expression NN cord-015021-pol2qm74 1584 14 ( ( -LRB- cord-015021-pol2qm74 1584 15 < < NNP cord-015021-pol2qm74 1584 16 30 30 CD cord-015021-pol2qm74 1584 17 % % NN cord-015021-pol2qm74 1584 18 ) ) -RRB- cord-015021-pol2qm74 1584 19 predicts predict VBZ cord-015021-pol2qm74 1584 20 fatal fatal JJ cord-015021-pol2qm74 1584 21 outcome outcome NN cord-015021-pol2qm74 1584 22 ( ( -LRB- cord-015021-pol2qm74 1584 23 mortality mortality NN cord-015021-pol2qm74 1584 24 > > XX cord-015021-pol2qm74 1584 25 85 85 CD cord-015021-pol2qm74 1584 26 % % NN cord-015021-pol2qm74 1584 27 ) ) -RRB- cord-015021-pol2qm74 1584 28 . . . cord-015021-pol2qm74 1585 1 The the DT cord-015021-pol2qm74 1585 2 altered altered JJ cord-015021-pol2qm74 1585 3 phenotype phenotype NN cord-015021-pol2qm74 1585 4 was be VBD cord-015021-pol2qm74 1585 5 associated associate VBN cord-015021-pol2qm74 1585 6 with with IN cord-015021-pol2qm74 1585 7 a a DT cord-015021-pol2qm74 1585 8 functional functional JJ cord-015021-pol2qm74 1585 9 deactivation deactivation NN cord-015021-pol2qm74 1585 10 of of IN cord-015021-pol2qm74 1585 11 monocytes monocyte NNS cord-015021-pol2qm74 1585 12 ( ( -LRB- cord-015021-pol2qm74 1585 13 diminished diminish VBD cord-015021-pol2qm74 1585 14 APC APC NNP cord-015021-pol2qm74 1585 15 , , , cord-015021-pol2qm74 1585 16 ROS ROS NNP cord-015021-pol2qm74 1585 17 formation formation NN cord-015021-pol2qm74 1585 18 , , , cord-015021-pol2qm74 1585 19 cytokine cytokine JJ cord-015021-pol2qm74 1585 20 secretion secretion NN cord-015021-pol2qm74 1585 21 ) ) -RRB- cord-015021-pol2qm74 1585 22 . . . cord-015021-pol2qm74 1586 1 We -PRON- PRP cord-015021-pol2qm74 1586 2 called call VBD cord-015021-pol2qm74 1586 3 this this DT cord-015021-pol2qm74 1586 4 phenomenon phenomenon NN cord-015021-pol2qm74 1586 5 " " `` cord-015021-pol2qm74 1586 6 immunoparalysis immunoparalysis NN cord-015021-pol2qm74 1586 7 " " '' cord-015021-pol2qm74 1586 8 . . . cord-015021-pol2qm74 1587 1 IFN IFN NNP cord-015021-pol2qm74 1587 2 - - HYPH cord-015021-pol2qm74 1587 3 gamma gamma NN cord-015021-pol2qm74 1587 4 and and CC cord-015021-pol2qm74 1587 5 GM GM NNP cord-015021-pol2qm74 1587 6 - - HYPH cord-015021-pol2qm74 1587 7 CSF CSF NNP cord-015021-pol2qm74 1587 8 were be VBD cord-015021-pol2qm74 1587 9 able able JJ cord-015021-pol2qm74 1587 10 to to TO cord-015021-pol2qm74 1587 11 restore restore VB cord-015021-pol2qm74 1587 12 the the DT cord-015021-pol2qm74 1587 13 altered altered JJ cord-015021-pol2qm74 1587 14 phenotype phenotype NN cord-015021-pol2qm74 1587 15 and and CC cord-015021-pol2qm74 1587 16 function function VB cord-015021-pol2qm74 1587 17 in in IN cord-015021-pol2qm74 1587 18 vitro vitro FW cord-015021-pol2qm74 1587 19 . . . cord-015021-pol2qm74 1588 1 However however RB cord-015021-pol2qm74 1588 2 , , , cord-015021-pol2qm74 1588 3 addition addition NN cord-015021-pol2qm74 1588 4 of of IN cord-015021-pol2qm74 1588 5 autologous autologous JJ cord-015021-pol2qm74 1588 6 plasma plasma NN cord-015021-pol2qm74 1588 7 from from IN cord-015021-pol2qm74 1588 8 septic septic JJ cord-015021-pol2qm74 1588 9 patients patient NNS cord-015021-pol2qm74 1588 10 with with IN cord-015021-pol2qm74 1588 11 " " `` cord-015021-pol2qm74 1588 12 immunoparalysis immunoparalysis NN cord-015021-pol2qm74 1588 13 " " '' cord-015021-pol2qm74 1588 14 to to IN cord-015021-pol2qm74 1588 15 these these DT cord-015021-pol2qm74 1588 16 cultures culture NNS cord-015021-pol2qm74 1588 17 prevented prevent VBD cord-015021-pol2qm74 1588 18 the the DT cord-015021-pol2qm74 1588 19 cytokine cytokine NN cord-015021-pol2qm74 1588 20 - - HYPH cord-015021-pol2qm74 1588 21 induced induce VBN cord-015021-pol2qm74 1588 22 restitution restitution NN cord-015021-pol2qm74 1588 23 . . . cord-015021-pol2qm74 1589 1 The the DT cord-015021-pol2qm74 1589 2 inhibitory inhibitory JJ cord-015021-pol2qm74 1589 3 activity activity NN cord-015021-pol2qm74 1589 4 could could MD cord-015021-pol2qm74 1589 5 not not RB cord-015021-pol2qm74 1589 6 be be VB cord-015021-pol2qm74 1589 7 removed remove VBN cord-015021-pol2qm74 1589 8 by by IN cord-015021-pol2qm74 1589 9 dialysis dialysis NN cord-015021-pol2qm74 1589 10 . . . cord-015021-pol2qm74 1590 1 Therefore therefore RB cord-015021-pol2qm74 1590 2 , , , cord-015021-pol2qm74 1590 3 we -PRON- PRP cord-015021-pol2qm74 1590 4 started start VBD cord-015021-pol2qm74 1590 5 a a DT cord-015021-pol2qm74 1590 6 study study NN cord-015021-pol2qm74 1590 7 to to TO cord-015021-pol2qm74 1590 8 prove prove VB cord-015021-pol2qm74 1590 9 the the DT cord-015021-pol2qm74 1590 10 therapeutic therapeutic JJ cord-015021-pol2qm74 1590 11 efficacy efficacy NN cord-015021-pol2qm74 1590 12 of of IN cord-015021-pol2qm74 1590 13 plasmapheresis plasmapheresis NN cord-015021-pol2qm74 1590 14 . . . cord-015021-pol2qm74 1591 1 Indeed indeed RB cord-015021-pol2qm74 1591 2 , , , cord-015021-pol2qm74 1591 3 [ [ -LRB- cord-015021-pol2qm74 1591 4 7 7 CD cord-015021-pol2qm74 1591 5 of of IN cord-015021-pol2qm74 1591 6 33 33 CD cord-015021-pol2qm74 1591 7 patients patient NNS cord-015021-pol2qm74 1591 8 recovered recover VBN cord-015021-pol2qm74 1591 9 from from IN cord-015021-pol2qm74 1591 10 " " `` cord-015021-pol2qm74 1591 11 immunoparalysis immunoparalysis NN cord-015021-pol2qm74 1591 12 " " '' cord-015021-pol2qm74 1591 13 following follow VBG cord-015021-pol2qm74 1591 14 repeated repeat VBN cord-015021-pol2qm74 1591 15 plasmapheres plasmaphere NNS cord-015021-pol2qm74 1591 16 ; ; : cord-015021-pol2qm74 1591 17 16 16 CD cord-015021-pol2qm74 1591 18 of of IN cord-015021-pol2qm74 1591 19 them -PRON- PRP cord-015021-pol2qm74 1591 20 survived survive VBD cord-015021-pol2qm74 1591 21 ( ( -LRB- cord-015021-pol2qm74 1591 22 46 46 CD cord-015021-pol2qm74 1591 23 % % NN cord-015021-pol2qm74 1591 24 ) ) -RRB- cord-015021-pol2qm74 1591 25 . . . cord-015021-pol2qm74 1592 1 7 7 CD cord-015021-pol2qm74 1592 2 patients patient NNS cord-015021-pol2qm74 1592 3 recovered recover VBD cord-015021-pol2qm74 1592 4 temporarely temporarely RB cord-015021-pol2qm74 1592 5 and and CC cord-015021-pol2qm74 1592 6 9 9 CD cord-015021-pol2qm74 1592 7 patients patient NNS cord-015021-pol2qm74 1592 8 did do VBD cord-015021-pol2qm74 1592 9 not not RB cord-015021-pol2qm74 1592 10 respond respond VB cord-015021-pol2qm74 1592 11 ( ( -LRB- cord-015021-pol2qm74 1592 12 all all DT cord-015021-pol2qm74 1592 13 16 16 CD cord-015021-pol2qm74 1592 14 died die VBD cord-015021-pol2qm74 1592 15 ) ) -RRB- cord-015021-pol2qm74 1592 16 . . . cord-015021-pol2qm74 1593 1 The the DT cord-015021-pol2qm74 1593 2 survival survival NN cord-015021-pol2qm74 1593 3 rate rate NN cord-015021-pol2qm74 1593 4 in in IN cord-015021-pol2qm74 1593 5 the the DT cord-015021-pol2qm74 1593 6 control control NN cord-015021-pol2qm74 1593 7 group group NN cord-015021-pol2qm74 1593 8 of of IN cord-015021-pol2qm74 1593 9 septic septic JJ cord-015021-pol2qm74 1593 10 patients patient NNS cord-015021-pol2qm74 1593 11 with with IN cord-015021-pol2qm74 1593 12 persistent persistent JJ cord-015021-pol2qm74 1593 13 " " `` cord-015021-pol2qm74 1593 14 immunoparalysis immunoparalysis NN cord-015021-pol2qm74 1593 15 " " '' cord-015021-pol2qm74 1593 16 was be VBD cord-015021-pol2qm74 1593 17 4 4 CD cord-015021-pol2qm74 1593 18 of of IN cord-015021-pol2qm74 1593 19 38 38 CD cord-015021-pol2qm74 1593 20 ( ( -LRB- cord-015021-pol2qm74 1593 21 11 11 CD cord-015021-pol2qm74 1593 22 % % NN cord-015021-pol2qm74 1593 23 ; ; , cord-015021-pol2qm74 1593 24 p<0,01 p<0,01 NN cord-015021-pol2qm74 1593 25 ) ) -RRB- cord-015021-pol2qm74 1593 26 . . . cord-015021-pol2qm74 1594 1 In in IN cord-015021-pol2qm74 1594 2 summary summary NN cord-015021-pol2qm74 1594 3 , , , cord-015021-pol2qm74 1594 4 plasmapheresis plasmapheresis NN cord-015021-pol2qm74 1594 5 in in IN cord-015021-pol2qm74 1594 6 association association NN cord-015021-pol2qm74 1594 7 with with IN cord-015021-pol2qm74 1594 8 immune immune JJ cord-015021-pol2qm74 1594 9 monitoring monitoring NN cord-015021-pol2qm74 1594 10 may may MD cord-015021-pol2qm74 1594 11 be be VB cord-015021-pol2qm74 1594 12 an an DT cord-015021-pol2qm74 1594 13 alternative alternative JJ cord-015021-pol2qm74 1594 14 strategy strategy NN cord-015021-pol2qm74 1594 15 to to TO cord-015021-pol2qm74 1594 16 improve improve VB cord-015021-pol2qm74 1594 17 survival survival NN cord-015021-pol2qm74 1594 18 rate rate NN cord-015021-pol2qm74 1594 19 in in IN cord-015021-pol2qm74 1594 20 severe severe JJ cord-015021-pol2qm74 1594 21 sepsis sepsis NN cord-015021-pol2qm74 1594 22 . . . cord-015021-pol2qm74 1595 1 Taurolidine Taurolidine NNP cord-015021-pol2qm74 1595 2 , , , cord-015021-pol2qm74 1595 3 a a DT cord-015021-pol2qm74 1595 4 synthetic synthetic JJ cord-015021-pol2qm74 1595 5 taurine taurine NN cord-015021-pol2qm74 1595 6 - - HYPH cord-015021-pol2qm74 1595 7 formaldehyde formaldehyde NN cord-015021-pol2qm74 1595 8 derivative derivative NN cord-015021-pol2qm74 1595 9 has have VBZ cord-015021-pol2qm74 1595 10 antiadherent antiadherent NN cord-015021-pol2qm74 1595 11 , , , cord-015021-pol2qm74 1595 12 bactericidal bactericidal JJ cord-015021-pol2qm74 1595 13 and and CC cord-015021-pol2qm74 1595 14 anti anti JJ cord-015021-pol2qm74 1595 15 - - JJ cord-015021-pol2qm74 1595 16 LPS lps JJ cord-015021-pol2qm74 1595 17 properties property NNS cord-015021-pol2qm74 1595 18 functioning function VBG cord-015021-pol2qm74 1595 19 primarily primarily RB cord-015021-pol2qm74 1595 20 through through IN cord-015021-pol2qm74 1595 21 binding binding NN cord-015021-pol2qm74 1595 22 of of IN cord-015021-pol2qm74 1595 23 the the DT cord-015021-pol2qm74 1595 24 lipid lipid NN cord-015021-pol2qm74 1595 25 A a DT cord-015021-pol2qm74 1595 26 region region NN cord-015021-pol2qm74 1595 27 of of IN cord-015021-pol2qm74 1595 28 the the DT cord-015021-pol2qm74 1595 29 LPS LPS NNP cord-015021-pol2qm74 1595 30 molecule molecule NN cord-015021-pol2qm74 1595 31 . . . cord-015021-pol2qm74 1596 1 The the DT cord-015021-pol2qm74 1596 2 active active JJ cord-015021-pol2qm74 1596 3 derivative derivative NN cord-015021-pol2qm74 1596 4 of of IN cord-015021-pol2qm74 1596 5 Taurolidine Taurolidine NNP cord-015021-pol2qm74 1596 6 , , , cord-015021-pol2qm74 1596 7 taurine taurine NN cord-015021-pol2qm74 1596 8 , , , cord-015021-pol2qm74 1596 9 modulates modulate VBZ cord-015021-pol2qm74 1596 10 calcium calcium NN cord-015021-pol2qm74 1596 11 channel channel NN cord-015021-pol2qm74 1596 12 activity activity NN cord-015021-pol2qm74 1596 13 , , , cord-015021-pol2qm74 1596 14 critical critical JJ cord-015021-pol2qm74 1596 15 to to IN cord-015021-pol2qm74 1596 16 the the DT cord-015021-pol2qm74 1596 17 initiation initiation NN cord-015021-pol2qm74 1596 18 of of IN cord-015021-pol2qm74 1596 19 a a DT cord-015021-pol2qm74 1596 20 number number NN cord-015021-pol2qm74 1596 21 of of IN cord-015021-pol2qm74 1596 22 immunostimulatory immunostimulatory NNP cord-015021-pol2qm74 1596 23 pathways pathway NNS cord-015021-pol2qm74 1596 24 . . . cord-015021-pol2qm74 1597 1 We -PRON- PRP cord-015021-pol2qm74 1597 2 hypothesised hypothesise VBD cord-015021-pol2qm74 1597 3 that that IN cord-015021-pol2qm74 1597 4 Taurolidine Taurolidine NNP cord-015021-pol2qm74 1597 5 may may MD cord-015021-pol2qm74 1597 6 have have VB cord-015021-pol2qm74 1597 7 direct direct JJ cord-015021-pol2qm74 1597 8 immunostimulatory immunostimulatory NN cord-015021-pol2qm74 1597 9 activity activity NN cord-015021-pol2qm74 1597 10 . . . cord-015021-pol2qm74 1598 1 The the DT cord-015021-pol2qm74 1598 2 aim aim NN cord-015021-pol2qm74 1598 3 of of IN cord-015021-pol2qm74 1598 4 this this DT cord-015021-pol2qm74 1598 5 study study NN cord-015021-pol2qm74 1598 6 was be VBD cord-015021-pol2qm74 1598 7 to to TO cord-015021-pol2qm74 1598 8 investigate investigate VB cord-015021-pol2qm74 1598 9 the the DT cord-015021-pol2qm74 1598 10 immune immune JJ cord-015021-pol2qm74 1598 11 effects effect NNS cord-015021-pol2qm74 1598 12 of of IN cord-015021-pol2qm74 1598 13 Taurolidine Taurolidine NNP cord-015021-pol2qm74 1598 14 on on IN cord-015021-pol2qm74 1598 15 peritoneal peritoneal JJ cord-015021-pol2qm74 1598 16 macrophage macrophage NN cord-015021-pol2qm74 1598 17 ( ( -LRB- cord-015021-pol2qm74 1598 18 PMO PMO NNP cord-015021-pol2qm74 1598 19 ) ) -RRB- cord-015021-pol2qm74 1598 20 function function NN cord-015021-pol2qm74 1598 21 and and CC cord-015021-pol2qm74 1598 22 then then RB cord-015021-pol2qm74 1598 23 determine determine VB cord-015021-pol2qm74 1598 24 the the DT cord-015021-pol2qm74 1598 25 role role NN cord-015021-pol2qm74 1598 26 of of IN cord-015021-pol2qm74 1598 27 taurine taurine NN cord-015021-pol2qm74 1598 28 in in IN cord-015021-pol2qm74 1598 29 this this DT cord-015021-pol2qm74 1598 30 response response NN cord-015021-pol2qm74 1598 31 . . . cord-015021-pol2qm74 1599 1 Study study NN cord-015021-pol2qm74 1599 2 1 1 CD cord-015021-pol2qm74 1599 3 : : : cord-015021-pol2qm74 1600 1 In in IN cord-015021-pol2qm74 1600 2 vivo vivo NN cord-015021-pol2qm74 1600 3 stimulation stimulation NN cord-015021-pol2qm74 1600 4 : : : cord-015021-pol2qm74 1600 5 CD-1 CD-1 NNP cord-015021-pol2qm74 1600 6 mice mouse NNS cord-015021-pol2qm74 1600 7 ( ( -LRB- cord-015021-pol2qm74 1600 8 n=35 n=35 NN cord-015021-pol2qm74 1600 9 ) ) -RRB- cord-015021-pol2qm74 1600 10 were be VBD cord-015021-pol2qm74 1600 11 randomized randomize VBN cord-015021-pol2qm74 1600 12 to to TO cord-015021-pol2qm74 1600 13 receive receive VB cord-015021-pol2qm74 1600 14 Taurolidine Taurolidine NNP cord-015021-pol2qm74 1600 15 ( ( -LRB- cord-015021-pol2qm74 1600 16 200mg 200mg NNP cord-015021-pol2qm74 1600 17 / / SYM cord-015021-pol2qm74 1600 18 kg kg NNP cord-015021-pol2qm74 1600 19 BW BW NNP cord-015021-pol2qm74 1600 20 / / SYM cord-015021-pol2qm74 1600 21 i.p i.p NNP cord-015021-pol2qm74 1600 22 . . NNP cord-015021-pol2qm74 1600 23 ) ) -RRB- cord-015021-pol2qm74 1600 24 or or CC cord-015021-pol2qm74 1600 25 saline saline NN cord-015021-pol2qm74 1600 26 cor cor NNP cord-015021-pol2qm74 1600 27 ~ ~ NNP cord-015021-pol2qm74 1600 28 trol trol NNP cord-015021-pol2qm74 1600 29 . . . cord-015021-pol2qm74 1601 1 PeritoneaI peritoneai JJ cord-015021-pol2qm74 1601 2 cells cell NNS cord-015021-pol2qm74 1601 3 were be VBD cord-015021-pol2qm74 1601 4 harvested harvest VBN cord-015021-pol2qm74 1601 5 after after IN cord-015021-pol2qm74 1601 6 24 24 CD cord-015021-pol2qm74 1601 7 hours hour NNS cord-015021-pol2qm74 1601 8 and and CC cord-015021-pol2qm74 1601 9 were be VBD cord-015021-pol2qm74 1601 10 assessed assess VBN cord-015021-pol2qm74 1601 11 for for IN cord-015021-pol2qm74 1601 12 PM0 pm0 NN cord-015021-pol2qm74 1601 13 function function NN cord-015021-pol2qm74 1601 14 [ [ -LRB- cord-015021-pol2qm74 1601 15 Superoxide superoxide NN cord-015021-pol2qm74 1601 16 anion anion NN cord-015021-pol2qm74 1601 17 generation generation NN cord-015021-pol2qm74 1601 18 ( ( -LRB- cord-015021-pol2qm74 1601 19 O2- o2- UH cord-015021-pol2qm74 1601 20 ) ) -RRB- cord-015021-pol2qm74 1601 21 , , , cord-015021-pol2qm74 1601 22 Nitric nitric NN cord-015021-pol2qm74 1601 23 oxide oxide NN cord-015021-pol2qm74 1601 24 ( ( -LRB- cord-015021-pol2qm74 1601 25 NO no RB cord-015021-pol2qm74 1601 26 ) ) -RRB- cord-015021-pol2qm74 1601 27 , , , cord-015021-pol2qm74 1601 28 Tumor tumor NN cord-015021-pol2qm74 1601 29 necrosis necrosis NN cord-015021-pol2qm74 1601 30 factor factor NN cord-015021-pol2qm74 1601 31 ( ( -LRB- cord-015021-pol2qm74 1601 32 TNF TNF NNP cord-015021-pol2qm74 1601 33 ) ) -RRB- cord-015021-pol2qm74 1601 34 , , , cord-015021-pol2qm74 1601 35 Fc Fc NNP cord-015021-pol2qm74 1601 36 / / SYM cord-015021-pol2qm74 1601 37 CR3-mediated cr3-mediate VBN cord-015021-pol2qm74 1601 38 phagocytic phagocytic JJ cord-015021-pol2qm74 1601 39 function function NN cord-015021-pol2qm74 1601 40 ( ( -LRB- cord-015021-pol2qm74 1601 41 Phago Phago NNP cord-015021-pol2qm74 1601 42 ) ) -RRB- cord-015021-pol2qm74 1601 43 Study Study NNP cord-015021-pol2qm74 1601 44 2 2 CD cord-015021-pol2qm74 1601 45 : : : cord-015021-pol2qm74 1602 1 Control Control NNP cord-015021-pol2qm74 1602 2 PM0 PM0 NNP cord-015021-pol2qm74 1602 3 were be VBD cord-015021-pol2qm74 1602 4 harvested harvest VBN cord-015021-pol2qm74 1602 5 and and CC cord-015021-pol2qm74 1602 6 cultured culture VBN cord-015021-pol2qm74 1602 7 in in IN cord-015021-pol2qm74 1602 8 vitro vitro FW cord-015021-pol2qm74 1602 9 with with IN cord-015021-pol2qm74 1602 10 taurine taurine NN cord-015021-pol2qm74 1602 11 ( ( -LRB- cord-015021-pol2qm74 1602 12 1.0mg 1.0mg CD cord-015021-pol2qm74 1602 13 / / SYM cord-015021-pol2qm74 1602 14 ml ml NN cord-015021-pol2qm74 1602 15 for for IN cord-015021-pol2qm74 1602 16 10 10 CD cord-015021-pol2qm74 1602 17 hrs hrs NN cord-015021-pol2qm74 1602 18 ) ) -RRB- cord-015021-pol2qm74 1602 19 , , , cord-015021-pol2qm74 1602 20 after after IN cord-015021-pol2qm74 1602 21 which which WDT cord-015021-pol2qm74 1602 22 time time NN cord-015021-pol2qm74 1602 23 they -PRON- PRP cord-015021-pol2qm74 1602 24 were be VBD cord-015021-pol2qm74 1602 25 assayed assay VBN cord-015021-pol2qm74 1602 26 for for IN cord-015021-pol2qm74 1602 27 0 0 CD cord-015021-pol2qm74 1602 28 2-and 2-and CD cord-015021-pol2qm74 1602 29 TNF TNF NNP cord-015021-pol2qm74 1602 30 release release NN cord-015021-pol2qm74 1602 31 . . . cord-015021-pol2qm74 1603 1 In in IN cord-015021-pol2qm74 1603 2 vivo vivo NN cord-015021-pol2qm74 1603 3 stimulation stimulation NN cord-015021-pol2qm74 1603 4 with with IN cord-015021-pol2qm74 1603 5 Taurolidine Taurolidine NNP cord-015021-pol2qm74 1603 6 Taurolidine Taurolidine NNP cord-015021-pol2qm74 1603 7 has have VBZ cord-015021-pol2qm74 1603 8 specific specific JJ cord-015021-pol2qm74 1603 9 immunological immunological JJ cord-015021-pol2qm74 1603 10 effects effect NNS cord-015021-pol2qm74 1603 11 on on IN cord-015021-pol2qm74 1603 12 M0 m0 NN cord-015021-pol2qm74 1603 13 . . . cord-015021-pol2qm74 1604 1 Release release NN cord-015021-pol2qm74 1604 2 of of IN cord-015021-pol2qm74 1604 3 the the DT cord-015021-pol2qm74 1604 4 inflammatory inflammatory JJ cord-015021-pol2qm74 1604 5 mediators mediator NNS cord-015021-pol2qm74 1604 6 0 0 CD cord-015021-pol2qm74 1604 7 2-and 2-and CD cord-015021-pol2qm74 1604 8 TNF TNF NNP cord-015021-pol2qm74 1604 9 , , , cord-015021-pol2qm74 1604 10 and and CC cord-015021-pol2qm74 1604 11 Fc Fc NNP cord-015021-pol2qm74 1604 12 / / SYM cord-015021-pol2qm74 1604 13 CR3-mediated cr3-mediate VBN cord-015021-pol2qm74 1604 14 phagocytosis phagocytosis NN cord-015021-pol2qm74 1604 15 were be VBD cord-015021-pol2qm74 1604 16 significantly significantly RB cord-015021-pol2qm74 1604 17 increased increase VBN cord-015021-pol2qm74 1604 18 , , , cord-015021-pol2qm74 1604 19 while while IN cord-015021-pol2qm74 1604 20 release release NN cord-015021-pol2qm74 1604 21 of of IN cord-015021-pol2qm74 1604 22 the the DT cord-015021-pol2qm74 1604 23 endothelial endothelial JJ cord-015021-pol2qm74 1604 24 relaxing relaxing JJ cord-015021-pol2qm74 1604 25 factor factor NN cord-015021-pol2qm74 1604 26 NO no UH cord-015021-pol2qm74 1604 27 was be VBD cord-015021-pol2qm74 1604 28 significantly significantly RB cord-015021-pol2qm74 1604 29 reduced reduce VBN cord-015021-pol2qm74 1604 30 . . . cord-015021-pol2qm74 1605 1 In in IN cord-015021-pol2qm74 1605 2 addition addition NN cord-015021-pol2qm74 1605 3 , , , cord-015021-pol2qm74 1605 4 the the DT cord-015021-pol2qm74 1605 5 amino amino NN cord-015021-pol2qm74 1605 6 acid acid NN cord-015021-pol2qm74 1605 7 taurine taurine NN cord-015021-pol2qm74 1605 8 , , , cord-015021-pol2qm74 1605 9 which which WDT cord-015021-pol2qm74 1605 10 is be VBZ cord-015021-pol2qm74 1605 11 released release VBN cord-015021-pol2qm74 1605 12 as as IN cord-015021-pol2qm74 1605 13 a a DT cord-015021-pol2qm74 1605 14 byproduct byproduct NN cord-015021-pol2qm74 1605 15 of of IN cord-015021-pol2qm74 1605 16 Taurolidines Taurolidines NNPS cord-015021-pol2qm74 1605 17 breakdown breakdown NN cord-015021-pol2qm74 1605 18 has have VBZ cord-015021-pol2qm74 1605 19 an an DT cord-015021-pol2qm74 1605 20 immunostimulatory immunostimulatory JJ cord-015021-pol2qm74 1605 21 effect effect NN cord-015021-pol2qm74 1605 22 on on IN cord-015021-pol2qm74 1605 23 PMO PMO NNP cord-015021-pol2qm74 1605 24 and and CC cord-015021-pol2qm74 1605 25 may may MD cord-015021-pol2qm74 1605 26 be be VB cord-015021-pol2qm74 1605 27 the the DT cord-015021-pol2qm74 1605 28 active active JJ cord-015021-pol2qm74 1605 29 moeity moeity NN cord-015021-pol2qm74 1605 30 of of IN cord-015021-pol2qm74 1605 31 the the DT cord-015021-pol2qm74 1605 32 compound compound NN cord-015021-pol2qm74 1605 33 Tanrolidine Tanrolidine NNP cord-015021-pol2qm74 1605 34 . . . cord-015021-pol2qm74 1606 1 In in IN cord-015021-pol2qm74 1606 2 sepsis sepsis NN cord-015021-pol2qm74 1606 3 , , , cord-015021-pol2qm74 1606 4 a a DT cord-015021-pol2qm74 1606 5 number number NN cord-015021-pol2qm74 1606 6 of of IN cord-015021-pol2qm74 1606 7 mediators mediator NNS cord-015021-pol2qm74 1606 8 which which WDT cord-015021-pol2qm74 1606 9 affect affect VBP cord-015021-pol2qm74 1606 10 vasomotor vasomotor NN cord-015021-pol2qm74 1606 11 tone tone NN cord-015021-pol2qm74 1606 12 and and CC cord-015021-pol2qm74 1606 13 cardiovascular cardiovascular JJ cord-015021-pol2qm74 1606 14 function function NN cord-015021-pol2qm74 1606 15 are be VBP cord-015021-pol2qm74 1606 16 produced produce VBN cord-015021-pol2qm74 1606 17 . . . cord-015021-pol2qm74 1607 1 Inasmuch inasmuch IN cord-015021-pol2qm74 1607 2 as as IN cord-015021-pol2qm74 1607 3 sepsis sepsis NN cord-015021-pol2qm74 1607 4 causes cause VBZ cord-015021-pol2qm74 1607 5 decrease decrease NN cord-015021-pol2qm74 1607 6 in in IN cord-015021-pol2qm74 1607 7 systemic systemic JJ cord-015021-pol2qm74 1607 8 vascular vascular JJ cord-015021-pol2qm74 1607 9 resistance resistance NN cord-015021-pol2qm74 1607 10 ( ( -LRB- cord-015021-pol2qm74 1607 11 SVR SVR NNP cord-015021-pol2qm74 1607 12 ) ) -RRB- cord-015021-pol2qm74 1607 13 , , , cord-015021-pol2qm74 1607 14 attention attention NN cord-015021-pol2qm74 1607 15 is be VBZ cord-015021-pol2qm74 1607 16 usually usually RB cord-015021-pol2qm74 1607 17 focussed focusse VBN cord-015021-pol2qm74 1607 18 on on IN cord-015021-pol2qm74 1607 19 vasodilators vasodilator NNS cord-015021-pol2qm74 1607 20 such such JJ cord-015021-pol2qm74 1607 21 as as IN cord-015021-pol2qm74 1607 22 lactate lactate NN cord-015021-pol2qm74 1607 23 , , , cord-015021-pol2qm74 1607 24 tumor tumor NN cord-015021-pol2qm74 1607 25 necrosis necrosis NN cord-015021-pol2qm74 1607 26 factor factor NN cord-015021-pol2qm74 1607 27 , , , cord-015021-pol2qm74 1607 28 interleukin interleukin NN cord-015021-pol2qm74 1607 29 - - : cord-015021-pol2qm74 1607 30 i i PRP cord-015021-pol2qm74 1607 31 & & CC cord-015021-pol2qm74 1607 32 2 2 CD cord-015021-pol2qm74 1607 33 , , , cord-015021-pol2qm74 1607 34 and and CC cord-015021-pol2qm74 1607 35 nitric nitric NN cord-015021-pol2qm74 1607 36 oxide oxide NN cord-015021-pol2qm74 1607 37 . . . cord-015021-pol2qm74 1608 1 But but CC cord-015021-pol2qm74 1608 2 injury injury NN cord-015021-pol2qm74 1608 3 and and CC cord-015021-pol2qm74 1608 4 inflammation inflammation NN cord-015021-pol2qm74 1608 5 als0 als0 TO cord-015021-pol2qm74 1608 6 cause cause VBP cord-015021-pol2qm74 1608 7 production production NN cord-015021-pol2qm74 1608 8 of of IN cord-015021-pol2qm74 1608 9 several several JJ cord-015021-pol2qm74 1608 10 vasoconstrictors vasoconstrictor NNS cord-015021-pol2qm74 1608 11 whose whose WP$ cord-015021-pol2qm74 1608 12 effect effect NN cord-015021-pol2qm74 1608 13 may may MD cord-015021-pol2qm74 1608 14 not not RB cord-015021-pol2qm74 1608 15 be be VB cord-015021-pol2qm74 1608 16 evident evident JJ cord-015021-pol2qm74 1608 17 in in IN cord-015021-pol2qm74 1608 18 changed change VBN cord-015021-pol2qm74 1608 19 SVR SVR NNP cord-015021-pol2qm74 1608 20 , , , cord-015021-pol2qm74 1608 21 but but CC cord-015021-pol2qm74 1608 22 may may MD cord-015021-pol2qm74 1608 23 significantly significantly RB cord-015021-pol2qm74 1608 24 affect affect VB cord-015021-pol2qm74 1608 25 organ organ NN cord-015021-pol2qm74 1608 26 blood blood NN cord-015021-pol2qm74 1608 27 flow flow NN cord-015021-pol2qm74 1608 28 or or CC cord-015021-pol2qm74 1608 29 function function VB cord-015021-pol2qm74 1608 30 in in IN cord-015021-pol2qm74 1608 31 the the DT cord-015021-pol2qm74 1608 32 paracrine paracrine JJ cord-015021-pol2qm74 1608 33 environment environment NN cord-015021-pol2qm74 1608 34 . . . cord-015021-pol2qm74 1609 1 Endothelin Endothelin NNP cord-015021-pol2qm74 1609 2 ( ( -LRB- cord-015021-pol2qm74 1609 3 ET ET NNP cord-015021-pol2qm74 1609 4 ) ) -RRB- cord-015021-pol2qm74 1609 5 is be VBZ cord-015021-pol2qm74 1609 6 a a DT cord-015021-pol2qm74 1609 7 21 21 CD cord-015021-pol2qm74 1609 8 amino amino NN cord-015021-pol2qm74 1609 9 acid acid NN cord-015021-pol2qm74 1609 10 peptide peptide NN cord-015021-pol2qm74 1609 11 vasoconstrictor vasoconstrictor NN cord-015021-pol2qm74 1609 12 produced produce VBN cord-015021-pol2qm74 1609 13 by by IN cord-015021-pol2qm74 1609 14 ischemic ischemic JJ cord-015021-pol2qm74 1609 15 or or CC cord-015021-pol2qm74 1609 16 injured injured JJ cord-015021-pol2qm74 1609 17 endothelial endothelial JJ cord-015021-pol2qm74 1609 18 cells cell NNS cord-015021-pol2qm74 1609 19 ( ( -LRB- cord-015021-pol2qm74 1609 20 EC EC NNP cord-015021-pol2qm74 1609 21 's 's POS cord-015021-pol2qm74 1609 22 ) ) -RRB- cord-015021-pol2qm74 1609 23 . . . cord-015021-pol2qm74 1610 1 ET ET NNP cord-015021-pol2qm74 1610 2 is be VBZ cord-015021-pol2qm74 1610 3 also also RB cord-015021-pol2qm74 1610 4 a a DT cord-015021-pol2qm74 1610 5 potent potent JJ cord-015021-pol2qm74 1610 6 constrictor constrictor NN cord-015021-pol2qm74 1610 7 for for IN cord-015021-pol2qm74 1610 8 renal renal JJ cord-015021-pol2qm74 1610 9 mesangial mesangial JJ cord-015021-pol2qm74 1610 10 and and CC cord-015021-pol2qm74 1610 11 coronary coronary JJ cord-015021-pol2qm74 1610 12 vessels vessel NNS cord-015021-pol2qm74 1610 13 , , , cord-015021-pol2qm74 1610 14 an an DT cord-015021-pol2qm74 1610 15 endocrine endocrine JJ cord-015021-pol2qm74 1610 16 regulator regulator NN cord-015021-pol2qm74 1610 17 , , , cord-015021-pol2qm74 1610 18 and and CC cord-015021-pol2qm74 1610 19 a a DT cord-015021-pol2qm74 1610 20 negative negative JJ cord-015021-pol2qm74 1610 21 cardiac cardiac JJ cord-015021-pol2qm74 1610 22 inotrope inotrope NN cord-015021-pol2qm74 1610 23 . . . cord-015021-pol2qm74 1611 1 Systemic systemic JJ cord-015021-pol2qm74 1611 2 ET ET NNP cord-015021-pol2qm74 1611 3 levels level NNS cord-015021-pol2qm74 1611 4 increase increase VBP cord-015021-pol2qm74 1611 5 significantly significantly RB cord-015021-pol2qm74 1611 6 in in IN cord-015021-pol2qm74 1611 7 hypoperfusion hypoperfusion NN cord-015021-pol2qm74 1611 8 and and CC cord-015021-pol2qm74 1611 9 ischemia ischemia NN cord-015021-pol2qm74 1611 10 . . . cord-015021-pol2qm74 1612 1 While while IN cord-015021-pol2qm74 1612 2 ET ET NNP cord-015021-pol2qm74 1612 3 is be VBZ cord-015021-pol2qm74 1612 4 principally principally RB cord-015021-pol2qm74 1612 5 produced produce VBN cord-015021-pol2qm74 1612 6 by by IN cord-015021-pol2qm74 1612 7 EC EC NNP cord-015021-pol2qm74 1612 8 's 's POS cord-015021-pol2qm74 1612 9 , , , cord-015021-pol2qm74 1612 10 we -PRON- PRP cord-015021-pol2qm74 1612 11 asked ask VBD cord-015021-pol2qm74 1612 12 if if IN cord-015021-pol2qm74 1612 13 human human JJ cord-015021-pol2qm74 1612 14 monocytes monocyte NNS cord-015021-pol2qm74 1612 15 might may MD cord-015021-pol2qm74 1612 16 also also RB cord-015021-pol2qm74 1612 17 produce produce VB cord-015021-pol2qm74 1612 18 ET ET NNP cord-015021-pol2qm74 1612 19 and and CC cord-015021-pol2qm74 1612 20 thereby thereby RB cord-015021-pol2qm74 1612 21 regulate regulate VB cord-015021-pol2qm74 1612 22 vasomotor vasomotor NN cord-015021-pol2qm74 1612 23 tone tone NN cord-015021-pol2qm74 1612 24 in in IN cord-015021-pol2qm74 1612 25 areas area NNS cord-015021-pol2qm74 1612 26 of of IN cord-015021-pol2qm74 1612 27 inflammation inflammation NN cord-015021-pol2qm74 1612 28 . . . cord-015021-pol2qm74 1613 1 Monocytes monocyte NNS cord-015021-pol2qm74 1613 2 from from IN cord-015021-pol2qm74 1613 3 healthy healthy JJ cord-015021-pol2qm74 1613 4 donors donor NNS cord-015021-pol2qm74 1613 5 were be VBD cord-015021-pol2qm74 1613 6 separated separate VBN cord-015021-pol2qm74 1613 7 on on IN cord-015021-pol2qm74 1613 8 Ficoll Ficoll NNP cord-015021-pol2qm74 1613 9 , , , cord-015021-pol2qm74 1613 10 resuspended resuspend VBD cord-015021-pol2qm74 1613 11 in in IN cord-015021-pol2qm74 1613 12 RPMI RPMI NNP cord-015021-pol2qm74 1613 13 1640 1640 CD cord-015021-pol2qm74 1613 14 +5 +5 CD cord-015021-pol2qm74 1613 15 % % NN cord-015021-pol2qm74 1613 16 fetal fetal JJ cord-015021-pol2qm74 1613 17 calf calf NN cord-015021-pol2qm74 1613 18 serum serum NN cord-015021-pol2qm74 1613 19 and and CC cord-015021-pol2qm74 1613 20 stimulated stimulate VBD cord-015021-pol2qm74 1613 21 with with IN cord-015021-pol2qm74 1613 22 i0 i0 NNP cord-015021-pol2qm74 1613 23 ug ug NNP cord-015021-pol2qm74 1613 24 / / SYM cord-015021-pol2qm74 1613 25 ml ml NN cord-015021-pol2qm74 1613 26 endotoxin endotoxin NN cord-015021-pol2qm74 1613 27 ( ( -LRB- cord-015021-pol2qm74 1613 28 LPS LPS NNP cord-015021-pol2qm74 1613 29 ) ) -RRB- cord-015021-pol2qm74 1613 30 . . . cord-015021-pol2qm74 1614 1 ET ET NNP cord-015021-pol2qm74 1614 2 was be VBD cord-015021-pol2qm74 1614 3 measured measure VBN cord-015021-pol2qm74 1614 4 by by IN cord-015021-pol2qm74 1614 5 radioimmunoassay radioimmunoassay JJ cord-015021-pol2qm74 1614 6 . . . cord-015021-pol2qm74 1615 1 LPS LPS NNP cord-015021-pol2qm74 1615 2 - - HYPH cord-015021-pol2qm74 1615 3 stimulated stimulate VBN cord-015021-pol2qm74 1615 4 monocytes monocyte NNS cord-015021-pol2qm74 1615 5 produced produce VBD cord-015021-pol2qm74 1615 6 87 87 CD cord-015021-pol2qm74 1615 7 ! ! . cord-015021-pol2qm74 1616 1 6 6 CD cord-015021-pol2qm74 1616 2 fM fm CD cord-015021-pol2qm74 1616 3 of of IN cord-015021-pol2qm74 1616 4 ET/106 et/106 NN cord-015021-pol2qm74 1616 5 cells cell NNS cord-015021-pol2qm74 1616 6 ( ( -LRB- cord-015021-pol2qm74 1616 7 vs. vs. FW cord-015021-pol2qm74 1616 8 unstimulated unstimulated JJ cord-015021-pol2qm74 1616 9 controls control NNS cord-015021-pol2qm74 1616 10 of of IN cord-015021-pol2qm74 1616 11 < < $ cord-015021-pol2qm74 1616 12 25 25 CD cord-015021-pol2qm74 1616 13 ) ) -RRB- cord-015021-pol2qm74 1616 14 . . . cord-015021-pol2qm74 1617 1 This this DT cord-015021-pol2qm74 1617 2 calculates calculate VBZ cord-015021-pol2qm74 1617 3 to to IN cord-015021-pol2qm74 1617 4 15 15 CD cord-015021-pol2qm74 1617 5 - - SYM cord-015021-pol2qm74 1617 6 30 30 CD cord-015021-pol2qm74 1617 7 % % NN cord-015021-pol2qm74 1617 8 of of IN cord-015021-pol2qm74 1617 9 the the DT cord-015021-pol2qm74 1617 10 amount amount NN cord-015021-pol2qm74 1617 11 of of IN cord-015021-pol2qm74 1617 12 ET ET NNP cord-015021-pol2qm74 1617 13 observed observe VBD cord-015021-pol2qm74 1617 14 in in IN cord-015021-pol2qm74 1617 15 patients patient NNS cord-015021-pol2qm74 1617 16 with with IN cord-015021-pol2qm74 1617 17 low low JJ cord-015021-pol2qm74 1617 18 cardiac cardiac JJ cord-015021-pol2qm74 1617 19 output output NN cord-015021-pol2qm74 1617 20 , , , cord-015021-pol2qm74 1617 21 sepsis sepsis NN cord-015021-pol2qm74 1617 22 or or CC cord-015021-pol2qm74 1617 23 ischemia ischemia NN cord-015021-pol2qm74 1617 24 . . . cord-015021-pol2qm74 1618 1 We -PRON- PRP cord-015021-pol2qm74 1618 2 conclude conclude VBP cord-015021-pol2qm74 1618 3 that that IN cord-015021-pol2qm74 1618 4 ET ET NNP cord-015021-pol2qm74 1618 5 is be VBZ cord-015021-pol2qm74 1618 6 a a DT cord-015021-pol2qm74 1618 7 cytokine cytokine NN cord-015021-pol2qm74 1618 8 produced produce VBN cord-015021-pol2qm74 1618 9 by by IN cord-015021-pol2qm74 1618 10 both both DT cord-015021-pol2qm74 1618 11 EC EC NNP cord-015021-pol2qm74 1618 12 's 's POS cord-015021-pol2qm74 1618 13 and and CC cord-015021-pol2qm74 1618 14 monocytes monocyte VBZ cord-015021-pol2qm74 1618 15 with with IN cord-015021-pol2qm74 1618 16 potent potent JJ cord-015021-pol2qm74 1618 17 effects effect NNS cord-015021-pol2qm74 1618 18 on on IN cord-015021-pol2qm74 1618 19 numerous numerous JJ cord-015021-pol2qm74 1618 20 cells cell NNS cord-015021-pol2qm74 1618 21 and and CC cord-015021-pol2qm74 1618 22 organs organ NNS cord-015021-pol2qm74 1618 23 in in IN cord-015021-pol2qm74 1618 24 the the DT cord-015021-pol2qm74 1618 25 critically critically RB cord-015021-pol2qm74 1618 26 ill ill JJ cord-015021-pol2qm74 1618 27 . . . cord-015021-pol2qm74 1619 1 Wuppertal Wuppertal NNP cord-015021-pol2qm74 1619 2 5 5 CD cord-015021-pol2qm74 1619 3 , , , cord-015021-pol2qm74 1620 1 Germany Germany NNP cord-015021-pol2qm74 1620 2 We We NNP cord-015021-pol2qm74 1620 3 and and CC cord-015021-pol2qm74 1620 4 other other JJ cord-015021-pol2qm74 1620 5 authors author NNS cord-015021-pol2qm74 1620 6 showed show VBD cord-015021-pol2qm74 1620 7 that that IN cord-015021-pol2qm74 1620 8 fatal fatal JJ cord-015021-pol2qm74 1620 9 outcome outcome NN cord-015021-pol2qm74 1620 10 in in IN cord-015021-pol2qm74 1620 11 septic septic JJ cord-015021-pol2qm74 1620 12 disease disease NN cord-015021-pol2qm74 1620 13 is be VBZ cord-015021-pol2qm74 1620 14 associated associate VBN cord-015021-pol2qm74 1620 15 with with IN cord-015021-pol2qm74 1620 16 a a DT cord-015021-pol2qm74 1620 17 decreased decrease VBN cord-015021-pol2qm74 1620 18 capacity capacity NN cord-015021-pol2qm74 1620 19 of of IN cord-015021-pol2qm74 1620 20 peripheral peripheral JJ cord-015021-pol2qm74 1620 21 blood blood NN cord-015021-pol2qm74 1620 22 monocytes monocyte NNS cord-015021-pol2qm74 1620 23 for for IN cord-015021-pol2qm74 1620 24 the the DT cord-015021-pol2qm74 1620 25 in in FW cord-015021-pol2qm74 1620 26 vitro vitro FW cord-015021-pol2qm74 1620 27 production production NN cord-015021-pol2qm74 1620 28 of of IN cord-015021-pol2qm74 1620 29 proinflammatory proinflammatory JJ cord-015021-pol2qm74 1620 30 cytokines cytokine NNS cord-015021-pol2qm74 1620 31 , , , cord-015021-pol2qm74 1620 32 especially especially RB cord-015021-pol2qm74 1620 33 TNF tnf NN cord-015021-pol2qm74 1620 34 - - HYPH cord-015021-pol2qm74 1620 35 alpha alpha NN cord-015021-pol2qm74 1620 36 . . . cord-015021-pol2qm74 1621 1 We -PRON- PRP cord-015021-pol2qm74 1621 2 found find VBD cord-015021-pol2qm74 1621 3 that that IN cord-015021-pol2qm74 1621 4 this this DT cord-015021-pol2qm74 1621 5 monocytic monocytic JJ cord-015021-pol2qm74 1621 6 deactivation deactivation NN cord-015021-pol2qm74 1621 7 is be VBZ cord-015021-pol2qm74 1621 8 completed complete VBN cord-015021-pol2qm74 1621 9 by by IN cord-015021-pol2qm74 1621 10 a a DT cord-015021-pol2qm74 1621 11 persistent persistent JJ cord-015021-pol2qm74 1621 12 and and CC cord-015021-pol2qm74 1621 13 marked marked JJ cord-015021-pol2qm74 1621 14 decrease decrease NN cord-015021-pol2qm74 1621 15 of of IN cord-015021-pol2qm74 1621 16 HLA HLA NNP cord-015021-pol2qm74 1621 17 - - HYPH cord-015021-pol2qm74 1621 18 DR DR NNP cord-015021-pol2qm74 1621 19 expression expression NN cord-015021-pol2qm74 1621 20 on on IN cord-015021-pol2qm74 1621 21 monocytes monocyte NNS cord-015021-pol2qm74 1621 22 ( ( -LRB- cord-015021-pol2qm74 1621 23 < < NNP cord-015021-pol2qm74 1621 24 30 30 CD cord-015021-pol2qm74 1621 25 % % NN cord-015021-pol2qm74 1621 26 HLA HLA NNP cord-015021-pol2qm74 1621 27 - - HYPH cord-015021-pol2qm74 1621 28 DR+ DR+ NNP cord-015021-pol2qm74 1621 29 monocytes monocyte NNS cord-015021-pol2qm74 1621 30 ) ) -RRB- cord-015021-pol2qm74 1621 31 and and CC cord-015021-pol2qm74 1621 32 a a DT cord-015021-pol2qm74 1621 33 diminished diminished JJ cord-015021-pol2qm74 1621 34 antigen antigen NN cord-015021-pol2qm74 1621 35 presenting present VBG cord-015021-pol2qm74 1621 36 activity activity NN cord-015021-pol2qm74 1621 37 whereas whereas IN cord-015021-pol2qm74 1621 38 the the DT cord-015021-pol2qm74 1621 39 capacity capacity NN cord-015021-pol2qm74 1621 40 to to TO cord-015021-pol2qm74 1621 41 form form VB cord-015021-pol2qm74 1621 42 the the DT cord-015021-pol2qm74 1621 43 antiinflammatory antiinflammatory JJ cord-015021-pol2qm74 1621 44 IL-1 IL-1 NNP cord-015021-pol2qm74 1621 45 receptor receptor NN cord-015021-pol2qm74 1621 46 antagonist antagonist NN cord-015021-pol2qm74 1621 47 remains remain VBZ cord-015021-pol2qm74 1621 48 high high JJ cord-015021-pol2qm74 1621 49 . . . cord-015021-pol2qm74 1622 1 In in IN cord-015021-pol2qm74 1622 2 order order NN cord-015021-pol2qm74 1622 3 to to TO cord-015021-pol2qm74 1622 4 evaluate evaluate VB cord-015021-pol2qm74 1622 5 the the DT cord-015021-pol2qm74 1622 6 in in IN cord-015021-pol2qm74 1622 7 vivo vivo NN cord-015021-pol2qm74 1622 8 situation situation NN cord-015021-pol2qm74 1622 9 and and CC cord-015021-pol2qm74 1622 10 to to TO cord-015021-pol2qm74 1622 11 determine determine VB cord-015021-pol2qm74 1622 12 at at IN cord-015021-pol2qm74 1622 13 which which WDT cord-015021-pol2qm74 1622 14 level level NN cord-015021-pol2qm74 1622 15 TNFproduction tnfproduction NN cord-015021-pol2qm74 1622 16 / / , cord-015021-pol2qm74 1622 17 secretion secretion NN cord-015021-pol2qm74 1622 18 is be VBZ cord-015021-pol2qm74 1622 19 altered alter VBN cord-015021-pol2qm74 1622 20 we -PRON- PRP cord-015021-pol2qm74 1622 21 assessed assess VBD cord-015021-pol2qm74 1622 22 the the DT cord-015021-pol2qm74 1622 23 TNF TNF NNP cord-015021-pol2qm74 1622 24 - - HYPH cord-015021-pol2qm74 1622 25 alpha alpha NN cord-015021-pol2qm74 1622 26 mRNA mRNA NNP cord-015021-pol2qm74 1622 27 expression expression NN cord-015021-pol2qm74 1622 28 in in IN cord-015021-pol2qm74 1622 29 freshly freshly RB cord-015021-pol2qm74 1622 30 isolated isolate VBN cord-015021-pol2qm74 1622 31 peripheral peripheral JJ cord-015021-pol2qm74 1622 32 blood blood NN cord-015021-pol2qm74 1622 33 mononuclear mononuclear NN cord-015021-pol2qm74 1622 34 cells cell NNS cord-015021-pol2qm74 1622 35 ( ( -LRB- cord-015021-pol2qm74 1622 36 PBMNC PBMNC NNP cord-015021-pol2qm74 1622 37 ) ) -RRB- cord-015021-pol2qm74 1622 38 from from IN cord-015021-pol2qm74 1622 39 septic septic JJ cord-015021-pol2qm74 1622 40 patients patient NNS cord-015021-pol2qm74 1622 41 . . . cord-015021-pol2qm74 1623 1 TNF TNF NNP cord-015021-pol2qm74 1623 2 - - HYPH cord-015021-pol2qm74 1623 3 mRNA mRNA NNP cord-015021-pol2qm74 1623 4 was be VBD cord-015021-pol2qm74 1623 5 onty onty JJ cord-015021-pol2qm74 1623 6 rarely rarely RB cord-015021-pol2qm74 1623 7 detected detect VBN cord-015021-pol2qm74 1623 8 by by IN cord-015021-pol2qm74 1623 9 semiqaantitative semiqaantitative JJ cord-015021-pol2qm74 1623 10 polymerase polymerase NN cord-015021-pol2qm74 1623 11 chain chain NN cord-015021-pol2qm74 1623 12 reaction reaction NN cord-015021-pol2qm74 1623 13 in in IN cord-015021-pol2qm74 1623 14 PBMNC PBMNC NNP cord-015021-pol2qm74 1623 15 's 's POS cord-015021-pol2qm74 1623 16 from from IN cord-015021-pol2qm74 1623 17 septic septic JJ cord-015021-pol2qm74 1623 18 patients patient NNS cord-015021-pol2qm74 1623 19 with with IN cord-015021-pol2qm74 1623 20 monocyte monocyte NNP cord-015021-pol2qm74 1623 21 deactivation deactivation NN cord-015021-pol2qm74 1623 22 . . . cord-015021-pol2qm74 1624 1 Meanwhile meanwhile RB cord-015021-pol2qm74 1624 2 , , , cord-015021-pol2qm74 1624 3 it -PRON- PRP cord-015021-pol2qm74 1624 4 was be VBD cord-015021-pol2qm74 1624 5 found find VBN cord-015021-pol2qm74 1624 6 in in IN cord-015021-pol2qm74 1624 7 almost almost RB cord-015021-pol2qm74 1624 8 all all DT cord-015021-pol2qm74 1624 9 PBMNCs pbmnc NNS cord-015021-pol2qm74 1624 10 from from IN cord-015021-pol2qm74 1624 11 septic septic JJ cord-015021-pol2qm74 1624 12 patients patient NNS cord-015021-pol2qm74 1624 13 without without IN cord-015021-pol2qm74 1624 14 monocytic monocytic JJ cord-015021-pol2qm74 1624 15 deactivation deactivation NN cord-015021-pol2qm74 1624 16 . . . cord-015021-pol2qm74 1625 1 We -PRON- PRP cord-015021-pol2qm74 1625 2 wondered wonder VBD cord-015021-pol2qm74 1625 3 , , , cord-015021-pol2qm74 1625 4 whether whether IN cord-015021-pol2qm74 1625 5 IL IL NNP cord-015021-pol2qm74 1625 6 - - HYPH cord-015021-pol2qm74 1625 7 I0 I0 NNP cord-015021-pol2qm74 1625 8 , , , cord-015021-pol2qm74 1625 9 which which WDT cord-015021-pol2qm74 1625 10 , , , cord-015021-pol2qm74 1625 11 is be VBZ cord-015021-pol2qm74 1625 12 known know VBN cord-015021-pol2qm74 1625 13 to to TO cord-015021-pol2qm74 1625 14 depress depress VB cord-015021-pol2qm74 1625 15 monocytic monocytic JJ cord-015021-pol2qm74 1625 16 proinflammatoly proinflammatoly JJ cord-015021-pol2qm74 1625 17 response response NN cord-015021-pol2qm74 1625 18 and and CC cord-015021-pol2qm74 1625 19 MHC MHC NNP cord-015021-pol2qm74 1625 20 class class NN cord-015021-pol2qm74 1625 21 II II NNP cord-015021-pol2qm74 1625 22 expression expression NN cord-015021-pol2qm74 1625 23 , , , cord-015021-pol2qm74 1625 24 could could MD cord-015021-pol2qm74 1625 25 be be VB cord-015021-pol2qm74 1625 26 one one CD cord-015021-pol2qm74 1625 27 of of IN cord-015021-pol2qm74 1625 28 the the DT cord-015021-pol2qm74 1625 29 mediators mediator NNS cord-015021-pol2qm74 1625 30 in in IN cord-015021-pol2qm74 1625 31 fatal fatal JJ cord-015021-pol2qm74 1625 32 sepsis sepsis NN cord-015021-pol2qm74 1625 33 . . . cord-015021-pol2qm74 1626 1 In in IN cord-015021-pol2qm74 1626 2 fact fact NN cord-015021-pol2qm74 1626 3 , , , cord-015021-pol2qm74 1626 4 we -PRON- PRP cord-015021-pol2qm74 1626 5 found find VBD cord-015021-pol2qm74 1626 6 that that IN cord-015021-pol2qm74 1626 7 IL-10 IL-10 NNP cord-015021-pol2qm74 1626 8 message message NN cord-015021-pol2qm74 1626 9 in in IN cord-015021-pol2qm74 1626 10 PBMNCs pbmnc NNS cord-015021-pol2qm74 1626 11 of of IN cord-015021-pol2qm74 1626 12 septic septic JJ cord-015021-pol2qm74 1626 13 patients patient NNS cord-015021-pol2qm74 1626 14 peaked peak VBD cord-015021-pol2qm74 1626 15 in in IN cord-015021-pol2qm74 1626 16 the the DT cord-015021-pol2qm74 1626 17 beginning beginning NN cord-015021-pol2qm74 1626 18 phase phase NN cord-015021-pol2qm74 1626 19 of of IN cord-015021-pol2qm74 1626 20 monocytic monocytic JJ cord-015021-pol2qm74 1626 21 deactivation deactivation NN cord-015021-pol2qm74 1626 22 . . . cord-015021-pol2qm74 1627 1 In in IN cord-015021-pol2qm74 1627 2 further further JJ cord-015021-pol2qm74 1627 3 investigations investigation NNS cord-015021-pol2qm74 1627 4 we -PRON- PRP cord-015021-pol2qm74 1627 5 found find VBD cord-015021-pol2qm74 1627 6 that that IN cord-015021-pol2qm74 1627 7 TNF TNF NNP cord-015021-pol2qm74 1627 8 - - HYPH cord-015021-pol2qm74 1627 9 administration administration NN cord-015021-pol2qm74 1627 10 can can MD cord-015021-pol2qm74 1627 11 induce induce VB cord-015021-pol2qm74 1627 12 monocytic monocytic JJ cord-015021-pol2qm74 1627 13 deactivation deactivation NN cord-015021-pol2qm74 1627 14 in in IN cord-015021-pol2qm74 1627 15 a a DT cord-015021-pol2qm74 1627 16 murine murine JJ cord-015021-pol2qm74 1627 17 model model NN cord-015021-pol2qm74 1627 18 / / SYM cord-015021-pol2qm74 1627 19 n n NN cord-015021-pol2qm74 1627 20 vivo vivo NN cord-015021-pol2qm74 1627 21 and and CC cord-015021-pol2qm74 1627 22 provoke provoke VB cord-015021-pol2qm74 1627 23 IL-10 IL-10 NNP cord-015021-pol2qm74 1627 24 message message NN cord-015021-pol2qm74 1627 25 in in IN cord-015021-pol2qm74 1627 26 human human JJ cord-015021-pol2qm74 1627 27 PBMNCs pbmnc NNS cord-015021-pol2qm74 1627 28 in in IN cord-015021-pol2qm74 1627 29 vitro vitro FW cord-015021-pol2qm74 1627 30 . . . cord-015021-pol2qm74 1628 1 These these DT cord-015021-pol2qm74 1628 2 results result NNS cord-015021-pol2qm74 1628 3 support support VBP cord-015021-pol2qm74 1628 4 our -PRON- PRP$ cord-015021-pol2qm74 1628 5 hypothesis hypothesis NN cord-015021-pol2qm74 1628 6 that that IN cord-015021-pol2qm74 1628 7 an an DT cord-015021-pol2qm74 1628 8 excessive excessive JJ cord-015021-pol2qm74 1628 9 delivery delivery NN cord-015021-pol2qm74 1628 10 of of IN cord-015021-pol2qm74 1628 11 proinflammatory proinflammatory JJ cord-015021-pol2qm74 1628 12 cytokines cytokine NNS cord-015021-pol2qm74 1628 13 in in IN cord-015021-pol2qm74 1628 14 a a DT cord-015021-pol2qm74 1628 15 first first JJ cord-015021-pol2qm74 1628 16 phase phase NN cord-015021-pol2qm74 1628 17 can can MD cord-015021-pol2qm74 1628 18 induce induce VB cord-015021-pol2qm74 1628 19 an an DT cord-015021-pol2qm74 1628 20 overwheiming overwheiming JJ cord-015021-pol2qm74 1628 21 inhibitory inhibitory JJ cord-015021-pol2qm74 1628 22 feedback feedback NN cord-015021-pol2qm74 1628 23 , , , cord-015021-pol2qm74 1628 24 mediated mediate VBN cord-015021-pol2qm74 1628 25 by by IN cord-015021-pol2qm74 1628 26 immuninhibitory immuninhibitory JJ cord-015021-pol2qm74 1628 27 mediators mediator NNS cord-015021-pol2qm74 1628 28 like like IN cord-015021-pol2qm74 1628 29 IL IL NNP cord-015021-pol2qm74 1628 30 - - HYPH cord-015021-pol2qm74 1628 31 l0 l0 NNP cord-015021-pol2qm74 1628 32 , , , cord-015021-pol2qm74 1628 33 which which WDT cord-015021-pol2qm74 1628 34 leads lead VBZ cord-015021-pol2qm74 1628 35 to to TO cord-015021-pol2qm74 1628 36 often often RB cord-015021-pol2qm74 1628 37 fatal fatal JJ cord-015021-pol2qm74 1628 38 monocytic monocytic JJ cord-015021-pol2qm74 1628 39 deactivation deactivation NN cord-015021-pol2qm74 1628 40 in in IN cord-015021-pol2qm74 1628 41 a a DT cord-015021-pol2qm74 1628 42 second second JJ cord-015021-pol2qm74 1628 43 phase phase NN cord-015021-pol2qm74 1628 44 . . . cord-015021-pol2qm74 1629 1 Interferon interferon NN cord-015021-pol2qm74 1629 2 - - HYPH cord-015021-pol2qm74 1629 3 gamma gamma NN cord-015021-pol2qm74 1629 4 which which WDT cord-015021-pol2qm74 1629 5 is be VBZ cord-015021-pol2qm74 1629 6 known know VBN cord-015021-pol2qm74 1629 7 to to TO cord-015021-pol2qm74 1629 8 counteract counteract VB cord-015021-pol2qm74 1629 9 IL-10 IL-10 NNP cord-015021-pol2qm74 1629 10 production production NN cord-015021-pol2qm74 1629 11 and and CC cord-015021-pol2qm74 1629 12 the the DT cord-015021-pol2qm74 1629 13 effects effect NNS cord-015021-pol2qm74 1629 14 of of IN cord-015021-pol2qm74 1629 15 IL-10 IL-10 NNP cord-015021-pol2qm74 1629 16 on on IN cord-015021-pol2qm74 1629 17 monocytes monocyte NNS cord-015021-pol2qm74 1629 18 restores restore VBZ cord-015021-pol2qm74 1629 19 the the DT cord-015021-pol2qm74 1629 20 function function NN cord-015021-pol2qm74 1629 21 and and CC cord-015021-pol2qm74 1629 22 phenotype phenotype NN cord-015021-pol2qm74 1629 23 of of IN cord-015021-pol2qm74 1629 24 monocytes monocyte NNS cord-015021-pol2qm74 1629 25 from from IN cord-015021-pol2qm74 1629 26 septic septic JJ cord-015021-pol2qm74 1629 27 patients patient NNS cord-015021-pol2qm74 1629 28 with with IN cord-015021-pol2qm74 1629 29 monoq monoq NNP cord-015021-pol2qm74 1629 30 , , , cord-015021-pol2qm74 1629 31 te te NNP cord-015021-pol2qm74 1629 32 deactivation deactivation NN cord-015021-pol2qm74 1629 33 in in IN cord-015021-pol2qm74 1629 34 vitro vitro FW cord-015021-pol2qm74 1629 35 and and CC cord-015021-pol2qm74 1629 36 could could MD cord-015021-pol2qm74 1629 37 be be VB cord-015021-pol2qm74 1629 38 a a DT cord-015021-pol2qm74 1629 39 possible possible JJ cord-015021-pol2qm74 1629 40 therapeutic therapeutic JJ cord-015021-pol2qm74 1629 41 agent agent NN cord-015021-pol2qm74 1629 42 in in IN cord-015021-pol2qm74 1629 43 otherwise otherwise RB cord-015021-pol2qm74 1629 44 fatal fatal JJ cord-015021-pol2qm74 1629 45 sepsis sepsis NN cord-015021-pol2qm74 1629 46 . . . cord-015021-pol2qm74 1630 1 Our -PRON- PRP$ cord-015021-pol2qm74 1630 2 laboratory laboratory NN cord-015021-pol2qm74 1630 3 previously previously RB cord-015021-pol2qm74 1630 4 reported report VBD cord-015021-pol2qm74 1630 5 that that IN cord-015021-pol2qm74 1630 6 LPS LPS NNP cord-015021-pol2qm74 1630 7 dependent dependent JJ cord-015021-pol2qm74 1630 8 macrophagederived macrophagederive VBD cord-015021-pol2qm74 1630 9 TNF TNF NNP cord-015021-pol2qm74 1630 10 - - : cord-015021-pol2qm74 1630 11 a a DT cord-015021-pol2qm74 1630 12 production production NN cord-015021-pol2qm74 1630 13 can can MD cord-015021-pol2qm74 1630 14 be be VB cord-015021-pol2qm74 1630 15 enhanced enhance VBN cord-015021-pol2qm74 1630 16 by by IN cord-015021-pol2qm74 1630 17 pretreatment pretreatment NN cord-015021-pol2qm74 1630 18 with with IN cord-015021-pol2qm74 1630 19 LPS LPS NNP cord-015021-pol2qm74 1630 20 at at IN cord-015021-pol2qm74 1630 21 substimulatory substimulatory NN cord-015021-pol2qm74 1630 22 LPS lp NNS cord-015021-pol2qm74 1630 23 priming prime VBG cord-015021-pol2qm74 1630 24 doses dose NNS cord-015021-pol2qm74 1630 25 coincident coincident JJ cord-015021-pol2qm74 1630 26 with with IN cord-015021-pol2qm74 1630 27 a a DT cord-015021-pol2qm74 1630 28 suppression suppression NN cord-015021-pol2qm74 1630 29 of of IN cord-015021-pol2qm74 1630 30 LPS LPS NNP cord-015021-pol2qm74 1630 31 dependent dependent JJ cord-015021-pol2qm74 1630 32 nitric nitric NN cord-015021-pol2qm74 1630 33 oxide oxide NN cord-015021-pol2qm74 1630 34 ( ( -LRB- cord-015021-pol2qm74 1630 35 NO no UH cord-015021-pol2qm74 1630 36 ) ) -RRB- cord-015021-pol2qm74 1630 37 production production NN cord-015021-pol2qm74 1630 38 ( ( -LRB- cord-015021-pol2qm74 1630 39 Zhang Zhang NNP cord-015021-pol2qm74 1630 40 and and CC cord-015021-pol2qm74 1630 41 Morrison Morrison NNP cord-015021-pol2qm74 1630 42 , , , cord-015021-pol2qm74 1630 43 J. J. NNP cord-015021-pol2qm74 1630 44 Exp Exp NNP cord-015021-pol2qm74 1630 45 . . . cord-015021-pol2qm74 1631 1 Med Med NNP cord-015021-pol2qm74 1631 2 17:511 17:511 CD cord-015021-pol2qm74 1631 3 , , , cord-015021-pol2qm74 1631 4 1993 1993 CD cord-015021-pol2qm74 1631 5 ) ) -RRB- cord-015021-pol2qm74 1631 6 . . . cord-015021-pol2qm74 1632 1 In in IN cord-015021-pol2qm74 1632 2 order order NN cord-015021-pol2qm74 1632 3 to to TO cord-015021-pol2qm74 1632 4 extend extend VB cord-015021-pol2qm74 1632 5 the the DT cord-015021-pol2qm74 1632 6 characterization characterization NN cord-015021-pol2qm74 1632 7 of of IN cord-015021-pol2qm74 1632 8 these these DT cord-015021-pol2qm74 1632 9 LPS lp NNS cord-015021-pol2qm74 1632 10 priming prime VBG cord-015021-pol2qm74 1632 11 effects effect NNS cord-015021-pol2qm74 1632 12 in in IN cord-015021-pol2qm74 1632 13 mouse mouse NN cord-015021-pol2qm74 1632 14 macrophages macrophage NNS cord-015021-pol2qm74 1632 15 , , , cord-015021-pol2qm74 1632 16 we -PRON- PRP cord-015021-pol2qm74 1632 17 examined examine VBD cord-015021-pol2qm74 1632 18 the the DT cord-015021-pol2qm74 1632 19 capacity capacity NN cord-015021-pol2qm74 1632 20 of of IN cord-015021-pol2qm74 1632 21 substimulatory substimulatory NN cord-015021-pol2qm74 1632 22 LPS LPS NNP cord-015021-pol2qm74 1632 23 to to TO cord-015021-pol2qm74 1632 24 modify modify VB cord-015021-pol2qm74 1632 25 LPS LPS NNP cord-015021-pol2qm74 1632 26 dependent dependent JJ cord-015021-pol2qm74 1632 27 IL-6 IL-6 NNP cord-015021-pol2qm74 1632 28 production production NN cord-015021-pol2qm74 1632 29 . . . cord-015021-pol2qm74 1633 1 Macrophages macrophage NNS cord-015021-pol2qm74 1633 2 were be VBD cord-015021-pol2qm74 1633 3 obtained obtain VBN cord-015021-pol2qm74 1633 4 from from IN cord-015021-pol2qm74 1633 5 peritoneal peritoneal JJ cord-015021-pol2qm74 1633 6 exudate exudate NN cord-015021-pol2qm74 1633 7 of of IN cord-015021-pol2qm74 1633 8 thioglycollate thioglycollate NNP cord-015021-pol2qm74 1633 9 treated treat VBN cord-015021-pol2qm74 1633 10 C3Heb C3Heb NNP cord-015021-pol2qm74 1633 11 / / SYM cord-015021-pol2qm74 1633 12 FeJ fej NN cord-015021-pol2qm74 1633 13 mice mouse NNS cord-015021-pol2qm74 1633 14 and and CC cord-015021-pol2qm74 1633 15 cultured culture VBN cord-015021-pol2qm74 1633 16 in in IN cord-015021-pol2qm74 1633 17 RPMI RPMI NNP cord-015021-pol2qm74 1633 18 1640 1640 CD cord-015021-pol2qm74 1633 19 medium medium NN cord-015021-pol2qm74 1633 20 containing contain VBG cord-015021-pol2qm74 1633 21 10 10 CD cord-015021-pol2qm74 1633 22 % % NN cord-015021-pol2qm74 1633 23 fetal fetal JJ cord-015021-pol2qm74 1633 24 bovine bovine JJ cord-015021-pol2qm74 1633 25 serum serum NN cord-015021-pol2qm74 1633 26 . . . cord-015021-pol2qm74 1634 1 Macrophages macrophage NNS cord-015021-pol2qm74 1634 2 were be VBD cord-015021-pol2qm74 1634 3 pretreated pretreate VBN cord-015021-pol2qm74 1634 4 with with IN cord-015021-pol2qm74 1634 5 various various JJ cord-015021-pol2qm74 1634 6 subthreshold subthreshold NN cord-015021-pol2qm74 1634 7 stimulatory stimulatory JJ cord-015021-pol2qm74 1634 8 concentrations concentration NNS cord-015021-pol2qm74 1634 9 of of IN cord-015021-pol2qm74 1634 10 LPS LPS NNP cord-015021-pol2qm74 1634 11 ( ( -LRB- cord-015021-pol2qm74 1634 12 Olll Olll NNP cord-015021-pol2qm74 1634 13 : : : cord-015021-pol2qm74 1634 14 B4 B4 NNP cord-015021-pol2qm74 1634 15 ) ) -RRB- cord-015021-pol2qm74 1634 16 for for IN cord-015021-pol2qm74 1634 17 6 6 CD cord-015021-pol2qm74 1634 18 hours hour NNS cord-015021-pol2qm74 1634 19 , , , cord-015021-pol2qm74 1634 20 washed wash VBD cord-015021-pol2qm74 1634 21 three three CD cord-015021-pol2qm74 1634 22 times time NNS cord-015021-pol2qm74 1634 23 , , , cord-015021-pol2qm74 1634 24 and and CC cord-015021-pol2qm74 1634 25 then then RB cord-015021-pol2qm74 1634 26 stimulated stimulate VBD cord-015021-pol2qm74 1634 27 with with IN cord-015021-pol2qm74 1634 28 the the DT cord-015021-pol2qm74 1634 29 effective effective JJ cord-015021-pol2qm74 1634 30 stimulatory stimulatory JJ cord-015021-pol2qm74 1634 31 concentration concentration NN cord-015021-pol2qm74 1634 32 of of IN cord-015021-pol2qm74 1634 33 LPS LPS NNP cord-015021-pol2qm74 1634 34 for for IN cord-015021-pol2qm74 1634 35 18 18 CD cord-015021-pol2qm74 1634 36 hours hour NNS cord-015021-pol2qm74 1634 37 . . . cord-015021-pol2qm74 1635 1 The the DT cord-015021-pol2qm74 1635 2 amount amount NN cord-015021-pol2qm74 1635 3 of of IN cord-015021-pol2qm74 1635 4 IL-6 IL-6 NNP cord-015021-pol2qm74 1635 5 in in IN cord-015021-pol2qm74 1635 6 the the DT cord-015021-pol2qm74 1635 7 supernatant supernatant NN cord-015021-pol2qm74 1635 8 was be VBD cord-015021-pol2qm74 1635 9 measured measure VBN cord-015021-pol2qm74 1635 10 by by IN cord-015021-pol2qm74 1635 11 IL-6 IL-6 NNP cord-015021-pol2qm74 1635 12 dependent dependent JJ cord-015021-pol2qm74 1635 13 cell cell NN cord-015021-pol2qm74 1635 14 line line NN cord-015021-pol2qm74 1635 15 ( ( -LRB- cord-015021-pol2qm74 1635 16 B9 b9 NN cord-015021-pol2qm74 1635 17 and and CC cord-015021-pol2qm74 1635 18 7TD1 7td1 CD cord-015021-pol2qm74 1635 19 ) ) -RRB- cord-015021-pol2qm74 1635 20 proliferation proliferation NN cord-015021-pol2qm74 1635 21 assay assay NN cord-015021-pol2qm74 1635 22 . . . cord-015021-pol2qm74 1636 1 IL-6 IL-6 NNP cord-015021-pol2qm74 1636 2 was be VBD cord-015021-pol2qm74 1636 3 produced produce VBN cord-015021-pol2qm74 1636 4 by by IN cord-015021-pol2qm74 1636 5 macrophages macrophage NNS cord-015021-pol2qm74 1636 6 at at IN cord-015021-pol2qm74 1636 7 lower low JJR cord-015021-pol2qm74 1636 8 threshold threshold NN cord-015021-pol2qm74 1636 9 doses dose NNS cord-015021-pol2qm74 1636 10 of of IN cord-015021-pol2qm74 1636 11 LPS lp NNS cord-015021-pol2qm74 1636 12 than than IN cord-015021-pol2qm74 1636 13 those those DT cord-015021-pol2qm74 1636 14 required require VBN cord-015021-pol2qm74 1636 15 for for IN cord-015021-pol2qm74 1636 16 TNF TNF NNP cord-015021-pol2qm74 1636 17 - - HYPH cord-015021-pol2qm74 1636 18 o~ o~ NNP cord-015021-pol2qm74 1636 19 or or CC cord-015021-pol2qm74 1636 20 NO no DT cord-015021-pol2qm74 1636 21 production production NN cord-015021-pol2qm74 1636 22 . . . cord-015021-pol2qm74 1637 1 Subthreshold Subthreshold NNP cord-015021-pol2qm74 1637 2 doses dose NNS cord-015021-pol2qm74 1637 3 of of IN cord-015021-pol2qm74 1637 4 LPS LPS NNP cord-015021-pol2qm74 1637 5 modulated modulate VBD cord-015021-pol2qm74 1637 6 IL-6 IL-6 NNP cord-015021-pol2qm74 1637 7 production production NN cord-015021-pol2qm74 1637 8 in in IN cord-015021-pol2qm74 1637 9 a a DT cord-015021-pol2qm74 1637 10 biphasic biphasic JJ cord-015021-pol2qm74 1637 11 manner manner NN cord-015021-pol2qm74 1637 12 characterized characterize VBN cord-015021-pol2qm74 1637 13 by by IN cord-015021-pol2qm74 1637 14 an an DT cord-015021-pol2qm74 1637 15 initial initial JJ cord-015021-pol2qm74 1637 16 suppression suppression NN cord-015021-pol2qm74 1637 17 and and CC cord-015021-pol2qm74 1637 18 then then RB cord-015021-pol2qm74 1637 19 potentiation potentiation NN cord-015021-pol2qm74 1637 20 . . . cord-015021-pol2qm74 1638 1 Higher high JJR cord-015021-pol2qm74 1638 2 doses dose NNS cord-015021-pol2qm74 1638 3 resulted result VBD cord-015021-pol2qm74 1638 4 in in IN cord-015021-pol2qm74 1638 5 secretion secretion NN cord-015021-pol2qm74 1638 6 of of IN cord-015021-pol2qm74 1638 7 IL-6 IL-6 NNP cord-015021-pol2qm74 1638 8 during during IN cord-015021-pol2qm74 1638 9 the the DT cord-015021-pol2qm74 1638 10 initial initial JJ cord-015021-pol2qm74 1638 11 incubation incubation NN cord-015021-pol2qm74 1638 12 with with IN cord-015021-pol2qm74 1638 13 LPS LPS NNP cord-015021-pol2qm74 1638 14 and and CC cord-015021-pol2qm74 1638 15 subsequent subsequent JJ cord-015021-pol2qm74 1638 16 desensitization desensitization NN cord-015021-pol2qm74 1638 17 . . . cord-015021-pol2qm74 1639 1 IL-6 IL-6 NNP cord-015021-pol2qm74 1639 2 , , , cord-015021-pol2qm74 1639 3 like like IN cord-015021-pol2qm74 1639 4 TNF-~ TNF-~ NNP cord-015021-pol2qm74 1639 5 and and CC cord-015021-pol2qm74 1639 6 NO no UH cord-015021-pol2qm74 1639 7 , , , cord-015021-pol2qm74 1639 8 is be VBZ cord-015021-pol2qm74 1639 9 , , , cord-015021-pol2qm74 1639 10 therefore therefore RB cord-015021-pol2qm74 1639 11 , , , cord-015021-pol2qm74 1639 12 also also RB cord-015021-pol2qm74 1639 13 affected affect VBN cord-015021-pol2qm74 1639 14 by by IN cord-015021-pol2qm74 1639 15 LPS LPS NNP cord-015021-pol2qm74 1639 16 pretreatment pretreatment NN cord-015021-pol2qm74 1639 17 . . . cord-015021-pol2qm74 1640 1 Moreover moreover RB cord-015021-pol2qm74 1640 2 , , , cord-015021-pol2qm74 1640 3 TNF TNF NNP cord-015021-pol2qm74 1640 4 - - : cord-015021-pol2qm74 1640 5 a a NNP cord-015021-pol2qm74 1640 6 and and CC cord-015021-pol2qm74 1640 7 IL-6 IL-6 NNP cord-015021-pol2qm74 1640 8 shared share VBD cord-015021-pol2qm74 1640 9 the the DT cord-015021-pol2qm74 1640 10 similar similar JJ cord-015021-pol2qm74 1640 11 potentiational potentiational JJ cord-015021-pol2qm74 1640 12 pathway pathway NN cord-015021-pol2qm74 1640 13 , , , cord-015021-pol2qm74 1640 14 but but CC cord-015021-pol2qm74 1640 15 differed differ VBN cord-015021-pol2qm74 1640 16 by by IN cord-015021-pol2qm74 1640 17 the the DT cord-015021-pol2qm74 1640 18 fact fact NN cord-015021-pol2qm74 1640 19 that that IN cord-015021-pol2qm74 1640 20 only only RB cord-015021-pol2qm74 1640 21 IL-6 IL-6 NNP cord-015021-pol2qm74 1640 22 was be VBD cord-015021-pol2qm74 1640 23 inhibited inhibit VBN cord-015021-pol2qm74 1640 24 . . . cord-015021-pol2qm74 1641 1 ( ( -LRB- cord-015021-pol2qm74 1641 2 Supported support VBN cord-015021-pol2qm74 1641 3 by by IN cord-015021-pol2qm74 1641 4 R37 R37 NNP cord-015021-pol2qm74 1641 5 AI23447 AI23447 NNP cord-015021-pol2qm74 1641 6 and and CC cord-015021-pol2qm74 1641 7 PO1 PO1 NNP cord-015021-pol2qm74 1641 8 A54474 A54474 NNP cord-015021-pol2qm74 1641 9 . . . cord-015021-pol2qm74 1641 10 ) ) -RRB- cord-015021-pol2qm74 1642 1 Department Department NNP cord-015021-pol2qm74 1642 2 of of IN cord-015021-pol2qm74 1642 3 Microbiology Microbiology NNP cord-015021-pol2qm74 1642 4 , , , cord-015021-pol2qm74 1642 5 Molecular Molecular NNP cord-015021-pol2qm74 1642 6 Genetics Genetics NNP cord-015021-pol2qm74 1642 7 and and CC cord-015021-pol2qm74 1642 8 Immunology Immunology NNP cord-015021-pol2qm74 1642 9 and and CC cord-015021-pol2qm74 1642 10 the the DT cord-015021-pol2qm74 1642 11 Cancer Cancer NNP cord-015021-pol2qm74 1642 12 Center Center NNP cord-015021-pol2qm74 1642 13 , , , cord-015021-pol2qm74 1642 14 1000 1000 CD cord-015021-pol2qm74 1642 15 Wahl Wahl NNP cord-015021-pol2qm74 1642 16 East East NNP cord-015021-pol2qm74 1642 17 , , , cord-015021-pol2qm74 1642 18 University University NNP cord-015021-pol2qm74 1642 19 of of IN cord-015021-pol2qm74 1642 20 Kansas Kansas NNP cord-015021-pol2qm74 1642 21 Medical Medical NNP cord-015021-pol2qm74 1642 22 Center Center NNP cord-015021-pol2qm74 1642 23 , , , cord-015021-pol2qm74 1642 24 Kansas Kansas NNP cord-015021-pol2qm74 1642 25 City City NNP cord-015021-pol2qm74 1642 26 , , , cord-015021-pol2qm74 1642 27 KS KS NNP cord-015021-pol2qm74 1642 28 66160 66160 CD cord-015021-pol2qm74 1642 29 - - HYPH cord-015021-pol2qm74 1642 30 7832 7832 CD cord-015021-pol2qm74 1642 31 . . . cord-015021-pol2qm74 1643 1 Korolenko Korolenko NNP cord-015021-pol2qm74 1643 2 T.,Urazgaliev T.,Urazgaliev NNP cord-015021-pol2qm74 1643 3 K.,and K.,and NNP cord-015021-pol2qm74 1643 4 Arkhipov Arkhipov NNPS cord-015021-pol2qm74 1643 5 S. S. NNP cord-015021-pol2qm74 1644 1 The the DT cord-015021-pol2qm74 1644 2 role role NN cord-015021-pol2qm74 1644 3 of of IN cord-015021-pol2qm74 1644 4 macrophage macrophage NN cord-015021-pol2qm74 1644 5 ( ( -LRB- cord-015021-pol2qm74 1644 6 Mph Mph NNP cord-015021-pol2qm74 1644 7 ) ) -RRB- cord-015021-pol2qm74 1644 8 stimulation stimulation NN cord-015021-pol2qm74 1644 9 in in IN cord-015021-pol2qm74 1644 10 mechanism mechanism NN cord-015021-pol2qm74 1644 11 of of IN cord-015021-pol2qm74 1644 12 protective protective JJ cord-015021-pol2qm74 1644 13 effect effect NN cord-015021-pol2qm74 1644 14 of of IN cord-015021-pol2qm74 1644 15 new new JJ cord-015021-pol2qm74 1644 16 immunomodulators immunomodulator NNS cord-015021-pol2qm74 1644 17 yeast yeast NN cord-015021-pol2qm74 1644 18 polysaccharides polysaccharide NNS cord-015021-pol2qm74 1644 19 -heteropolysaccharide -heteropolysaccharide . cord-015021-pol2qm74 1645 1 Cryelan Cryelan NNP cord-015021-pol2qm74 1645 2 and and CC cord-015021-pol2qm74 1645 3 homopolysaccharide homopolysaccharide NNP cord-015021-pol2qm74 1645 4 mannan mannan NNP cord-015021-pol2qm74 1645 5 Rhodexman Rhodexman NNP cord-015021-pol2qm74 1645 6 ( ( -LRB- cord-015021-pol2qm74 1645 7 both both DT cord-015021-pol2qm74 1645 8 produced produce VBN cord-015021-pol2qm74 1645 9 by by IN cord-015021-pol2qm74 1645 10 Petersburg Petersburg NNP cord-015021-pol2qm74 1645 11 Chem.-Pharm Chem.-Pharm NNP cord-015021-pol2qm74 1645 12 . . . cord-015021-pol2qm74 1646 1 Inst Inst NNP cord-015021-pol2qm74 1646 2 . . . cord-015021-pol2qm74 1646 3 ) ) -RRB- cord-015021-pol2qm74 1646 4 was be VBD cord-015021-pol2qm74 1646 5 studied study VBN cord-015021-pol2qm74 1646 6 . . . cord-015021-pol2qm74 1647 1 In in IN cord-015021-pol2qm74 1647 2 vitro vitro FW cord-015021-pol2qm74 1647 3 according accord VBG cord-015021-pol2qm74 1647 4 to to IN cord-015021-pol2qm74 1647 5 NST NST NNP cord-015021-pol2qm74 1647 6 test test NN cord-015021-pol2qm74 1647 7 incubation incubation NN cord-015021-pol2qm74 1647 8 of of IN cord-015021-pol2qm74 1647 9 murine murine JJ cord-015021-pol2qm74 1647 10 peritoneal peritoneal JJ cord-015021-pol2qm74 1647 11 Mphs Mphs NNP cord-015021-pol2qm74 1647 12 with with IN cord-015021-pol2qm74 1647 13 Cryelan Cryelan NNP cord-015021-pol2qm74 1647 14 or or CC cord-015021-pol2qm74 1647 15 Rhodexman Rhodexman NNP cord-015021-pol2qm74 1647 16 , , , cord-015021-pol2qm74 1647 17 150 150 CD cord-015021-pol2qm74 1647 18 ~g ~g NNP cord-015021-pol2qm74 1647 19 / / SYM cord-015021-pol2qm74 1647 20 ml,30 ml,30 NNP cord-015021-pol2qm74 1647 21 min min NNP cord-015021-pol2qm74 1647 22 was be VBD cord-015021-pol2qm74 1647 23 followed follow VBN cord-015021-pol2qm74 1647 24 by by IN cord-015021-pol2qm74 1647 25 increase increase NN cord-015021-pol2qm74 1647 26 of of IN cord-015021-pol2qm74 1647 27 potencial potencial JJ cord-015021-pol2qm74 1647 28 microbicidic microbicidic NN cord-015021-pol2qm74 1647 29 activity activity NN cord-015021-pol2qm74 1647 30 of of IN cord-015021-pol2qm74 1647 31 Mphs Mphs NNP cord-015021-pol2qm74 1647 32 . . . cord-015021-pol2qm74 1648 1 In in IN cord-015021-pol2qm74 1648 2 vivo vivo NN cord-015021-pol2qm74 1648 3 Mph mph NN cord-015021-pol2qm74 1648 4 stimulation stimulation NN cord-015021-pol2qm74 1648 5 by by IN cord-015021-pol2qm74 1648 6 immunomodulators immunomodulator NNS cord-015021-pol2qm74 1648 7 studied study VBD cord-015021-pol2qm74 1648 8 included include VBN cord-015021-pol2qm74 1648 9 increase increase NN cord-015021-pol2qm74 1648 10 rate rate NN cord-015021-pol2qm74 1648 11 of of IN cord-015021-pol2qm74 1648 12 carbon carbon NN cord-015021-pol2qm74 1648 13 particles particle NNS cord-015021-pol2qm74 1648 14 phagocytosis phagocytosis NN cord-015021-pol2qm74 1648 15 during during IN cord-015021-pol2qm74 1648 16 single single JJ cord-015021-pol2qm74 1648 17 i.v i.v NNP cord-015021-pol2qm74 1648 18 . . NNP cord-015021-pol2qm74 1648 19 or or CC cord-015021-pol2qm74 1648 20 i.p i.p NNP cord-015021-pol2qm74 1648 21 . . NNP cord-015021-pol2qm74 1648 22 mode mode NNP cord-015021-pol2qm74 1648 23 of of IN cord-015021-pol2qm74 1648 24 administration administration NN cord-015021-pol2qm74 1648 25 to to IN cord-015021-pol2qm74 1648 26 mice mouse NNS cord-015021-pol2qm74 1648 27 1 1 CD cord-015021-pol2qm74 1648 28 - - SYM cord-015021-pol2qm74 1648 29 14 14 CD cord-015021-pol2qm74 1648 30 days day NNS cord-015021-pol2qm74 1648 31 after after IN cord-015021-pol2qm74 1648 32 ( ( -LRB- cord-015021-pol2qm74 1648 33 peak peak NN cord-015021-pol2qm74 1648 34 at at IN cord-015021-pol2qm74 1648 35 2nd 2nd JJ cord-015021-pol2qm74 1648 36 day day NN cord-015021-pol2qm74 1648 37 for for IN cord-015021-pol2qm74 1648 38 i.v i.v NNP cord-015021-pol2qm74 1648 39 . . . cord-015021-pol2qm74 1649 1 and and CC cord-015021-pol2qm74 1649 2 5th 5th JJ cord-015021-pol2qm74 1649 3 day day NN cord-015021-pol2qm74 1649 4 for for IN cord-015021-pol2qm74 1649 5 i.p i.p NNP cord-015021-pol2qm74 1649 6 . . NNP cord-015021-pol2qm74 1649 7 mode mode NNP cord-015021-pol2qm74 1649 8 of of IN cord-015021-pol2qm74 1649 9 administration administration NN cord-015021-pol2qm74 1649 10 of of IN cord-015021-pol2qm74 1649 11 the the DT cord-015021-pol2qm74 1649 12 same same JJ cord-015021-pol2qm74 1649 13 dose dose NN cord-015021-pol2qm74 1649 14 of of IN cord-015021-pol2qm74 1649 15 5 5 CD cord-015021-pol2qm74 1649 16 mg/100 mg/100 NNS cord-015021-pol2qm74 1649 17 g g NNP cord-015021-pol2qm74 1649 18 b.w.).The b.w.).The NNP cord-015021-pol2qm74 1649 19 preliminary preliminary JJ cord-015021-pol2qm74 1649 20 injection injection NN cord-015021-pol2qm74 1649 21 of of IN cord-015021-pol2qm74 1649 22 Cryelan Cryelan NNP cord-015021-pol2qm74 1649 23 ( ( -LRB- cord-015021-pol2qm74 1649 24 5 5 CD cord-015021-pol2qm74 1649 25 mg/100 mg/100 NNS cord-015021-pol2qm74 1649 26 g g NNP cord-015021-pol2qm74 1649 27 , , , cord-015021-pol2qm74 1649 28 24 24 CD cord-015021-pol2qm74 1649 29 or or CC cord-015021-pol2qm74 1649 30 48 48 CD cord-015021-pol2qm74 1649 31 h h NN cord-015021-pol2qm74 1649 32 before before IN cord-015021-pol2qm74 1649 33 ) ) -RRB- cord-015021-pol2qm74 1649 34 to to IN cord-015021-pol2qm74 1649 35 mice mouse NNS cord-015021-pol2qm74 1649 36 with with IN cord-015021-pol2qm74 1649 37 acute acute JJ cord-015021-pol2qm74 1649 38 cold cold JJ cord-015021-pol2qm74 1649 39 stress stress NN cord-015021-pol2qm74 1649 40 ( ( -LRB- cord-015021-pol2qm74 1650 1 -10 -10 `` cord-015021-pol2qm74 1650 2 ° ° NNP cord-015021-pol2qm74 1650 3 C C NNP cord-015021-pol2qm74 1650 4 , , , cord-015021-pol2qm74 1650 5 1 1 CD cord-015021-pol2qm74 1650 6 h h NN cord-015021-pol2qm74 1650 7 ) ) -RRB- cord-015021-pol2qm74 1650 8 revealed reveal VBD cord-015021-pol2qm74 1650 9 protective protective JJ cord-015021-pol2qm74 1650 10 effect effect NN cord-015021-pol2qm74 1650 11 restorating restorate VBG cord-015021-pol2qm74 1650 12 the the DT cord-015021-pol2qm74 1650 13 value value NN cord-015021-pol2qm74 1650 14 of of IN cord-015021-pol2qm74 1650 15 depressed depressed JJ cord-015021-pol2qm74 1650 16 phagocytosis phagocytosis NN cord-015021-pol2qm74 1650 17 up up RP cord-015021-pol2qm74 1650 18 to to IN cord-015021-pol2qm74 1650 19 the the DT cord-015021-pol2qm74 1650 20 normal normal JJ cord-015021-pol2qm74 1650 21 level;the level;the NNP cord-015021-pol2qm74 1650 22 positive positive JJ cord-015021-pol2qm74 1650 23 effect effect NN cord-015021-pol2qm74 1650 24 on on IN cord-015021-pol2qm74 1650 25 ultrastructure ultrastructure NN cord-015021-pol2qm74 1650 26 of of IN cord-015021-pol2qm74 1650 27 hepatocytes hepatocyte NNS cord-015021-pol2qm74 1650 28 was be VBD cord-015021-pol2qm74 1650 29 noted note VBN cord-015021-pol2qm74 1650 30 also also RB cord-015021-pol2qm74 1650 31 . . . cord-015021-pol2qm74 1651 1 There there EX cord-015021-pol2qm74 1651 2 was be VBD cord-015021-pol2qm74 1651 3 no no DT cord-015021-pol2qm74 1651 4 changes change NNS cord-015021-pol2qm74 1651 5 of of IN cord-015021-pol2qm74 1651 6 plasma plasma NN cord-015021-pol2qm74 1651 7 corticosterone corticosterone NN cord-015021-pol2qm74 1651 8 level level NN cord-015021-pol2qm74 1651 9 between between IN cord-015021-pol2qm74 1651 10 group group NN cord-015021-pol2qm74 1651 11 with with IN cord-015021-pol2qm74 1651 12 acute acute JJ cord-015021-pol2qm74 1651 13 cold cold JJ cord-015021-pol2qm74 1651 14 stress stress NN cord-015021-pol2qm74 1651 15 and and CC cord-015021-pol2qm74 1651 16 mice mouse NNS cord-015021-pol2qm74 1651 17 with with IN cord-015021-pol2qm74 1651 18 Cryelan Cryelan NNP cord-015021-pol2qm74 1651 19 + + CC cord-015021-pol2qm74 1651 20 acute acute JJ cord-015021-pol2qm74 1651 21 cold cold JJ cord-015021-pol2qm74 1651 22 stress stress NN cord-015021-pol2qm74 1651 23 ( ( -LRB- cord-015021-pol2qm74 1651 24 several several JJ cord-015021-pol2qm74 1651 25 fold fold JJ cord-015021-pol2qm74 1651 26 increase increase NN cord-015021-pol2qm74 1651 27 comparatively comparatively RB cord-015021-pol2qm74 1651 28 to to IN cord-015021-pol2qm74 1651 29 the the DT cord-015021-pol2qm74 1651 30 control control NN cord-015021-pol2qm74 1651 31 mice).As mice).As NNP cord-015021-pol2qm74 1651 32 was be VBD cord-015021-pol2qm74 1651 33 suggested suggest VBN cord-015021-pol2qm74 1651 34 , , , cord-015021-pol2qm74 1651 35 the the DT cord-015021-pol2qm74 1651 36 mechanism mechanism NN cord-015021-pol2qm74 1651 37 of of IN cord-015021-pol2qm74 1651 38 protection protection NN cord-015021-pol2qm74 1651 39 can can MD cord-015021-pol2qm74 1651 40 include include VB cord-015021-pol2qm74 1651 41 Mph mph NN cord-015021-pol2qm74 1651 42 stimulation stimulation NN cord-015021-pol2qm74 1651 43 and and CC cord-015021-pol2qm74 1651 44 secretion secretion NN cord-015021-pol2qm74 1651 45 of of IN cord-015021-pol2qm74 1651 46 some some DT cord-015021-pol2qm74 1651 47 acute acute JJ cord-015021-pol2qm74 1651 48 phase phase NN cord-015021-pol2qm74 1651 49 proteins protein NNS cord-015021-pol2qm74 1651 50 responsible responsible JJ cord-015021-pol2qm74 1651 51 for for IN cord-015021-pol2qm74 1651 52 positive positive JJ cord-015021-pol2qm74 1651 53 effect effect NN cord-015021-pol2qm74 1651 54 of of IN cord-015021-pol2qm74 1651 55 immunomodulators immunomodulator NNS cord-015021-pol2qm74 1651 56 . . . cord-015021-pol2qm74 1652 1 New new JJ cord-015021-pol2qm74 1652 2 yeast yeast NN cord-015021-pol2qm74 1652 3 polysaccharides polysaccharide NNS cord-015021-pol2qm74 1653 1 Cryelan Cryelan NNP cord-015021-pol2qm74 1653 2 and and CC cord-015021-pol2qm74 1653 3 Rhodexman Rhodexman NNP cord-015021-pol2qm74 1653 4 can can MD cord-015021-pol2qm74 1653 5 be be VB cord-015021-pol2qm74 1653 6 used use VBN cord-015021-pol2qm74 1653 7 for for IN cord-015021-pol2qm74 1653 8 macrophage macrophage NN cord-015021-pol2qm74 1653 9 stimulation stimulation NN cord-015021-pol2qm74 1653 10 , , , cord-015021-pol2qm74 1653 11 especially especially RB cord-015021-pol2qm74 1653 12 in in IN cord-015021-pol2qm74 1653 13 pathological pathological JJ cord-015021-pol2qm74 1653 14 states state NNS cord-015021-pol2qm74 1653 15 . . . cord-015021-pol2qm74 1654 1 Immunomodulators immunomodulator NNS cord-015021-pol2qm74 1654 2 were be VBD cord-015021-pol2qm74 1654 3 shown show VBN cord-015021-pol2qm74 1654 4 to to TO cord-015021-pol2qm74 1654 5 increase increase VB cord-015021-pol2qm74 1654 6 production production NN cord-015021-pol2qm74 1654 7 and and CC cord-015021-pol2qm74 1654 8 secretion secretion NN cord-015021-pol2qm74 1654 9 of of IN cord-015021-pol2qm74 1654 10 lysosomal lysosomal JJ cord-015021-pol2qm74 1654 11 enzymes enzyme NNS cord-015021-pol2qm74 1654 12 ( ( -LRB- cord-015021-pol2qm74 1654 13 like like IN cord-015021-pol2qm74 1654 14 zymosan zymosan NNP cord-015021-pol2qm74 1654 15 ) ) -RRB- cord-015021-pol2qm74 1654 16 . . . cord-015021-pol2qm74 1655 1 Secreted secrete VBN cord-015021-pol2qm74 1655 2 enzymes enzyme NNS cord-015021-pol2qm74 1655 3 , , , cord-015021-pol2qm74 1655 4 especially especially RB cord-015021-pol2qm74 1655 5 cysteine cysteine NN cord-015021-pol2qm74 1655 6 proteinasescathepsins proteinasescathepsin NNS cord-015021-pol2qm74 1655 7 B B NNP cord-015021-pol2qm74 1655 8 and and CC cord-015021-pol2qm74 1655 9 L L NNP cord-015021-pol2qm74 1655 10 -involve -involve NNP cord-015021-pol2qm74 1656 1 in in IN cord-015021-pol2qm74 1656 2 the the DT cord-015021-pol2qm74 1656 3 process process NN cord-015021-pol2qm74 1656 4 of of IN cord-015021-pol2qm74 1656 5 inflammation;however inflammation;however NNP cord-015021-pol2qm74 1656 6 , , , cord-015021-pol2qm74 1656 7 excessive excessive JJ cord-015021-pol2qm74 1656 8 release release NN cord-015021-pol2qm74 1656 9 of of IN cord-015021-pol2qm74 1656 10 these these DT cord-015021-pol2qm74 1656 11 enzymes enzyme NNS cord-015021-pol2qm74 1656 12 may may MD cord-015021-pol2qm74 1656 13 lead lead VB cord-015021-pol2qm74 1656 14 to to IN cord-015021-pol2qm74 1656 15 noncontrolled noncontrolled JJ cord-015021-pol2qm74 1656 16 proteolysis proteolysis NN cord-015021-pol2qm74 1656 17 followed follow VBN cord-015021-pol2qm74 1656 18 by by IN cord-015021-pol2qm74 1656 19 tissue tissue NN cord-015021-pol2qm74 1656 20 degradation degradation NN cord-015021-pol2qm74 1657 1 ( ( -LRB- cord-015021-pol2qm74 1657 2 Assfalg Assfalg NNP cord-015021-pol2qm74 1657 3 - - HYPH cord-015021-pol2qm74 1657 4 Machleidt Machleidt NNP cord-015021-pol2qm74 1657 5 et et NNP cord-015021-pol2qm74 1657 6 al al NNP cord-015021-pol2qm74 1657 7 . . NNP cord-015021-pol2qm74 1657 8 ,1990 ,1990 , cord-015021-pol2qm74 1657 9 ) ) -RRB- cord-015021-pol2qm74 1658 1 .The .The . cord-015021-pol2qm74 1659 1 effect effect NN cord-015021-pol2qm74 1659 2 of of IN cord-015021-pol2qm74 1659 3 zymosan zymosan NNP cord-015021-pol2qm74 1659 4 , , , cord-015021-pol2qm74 1659 5 BCG BCG NNP cord-015021-pol2qm74 1659 6 and and CC cord-015021-pol2qm74 1659 7 new new JJ cord-015021-pol2qm74 1659 8 immunomodulator immunomodulator NNP cord-015021-pol2qm74 1659 9 carboxymethylglucan carboxymethylglucan NNP cord-015021-pol2qm74 1659 10 ( ( -LRB- cord-015021-pol2qm74 1659 11 CMG CMG NNP cord-015021-pol2qm74 1659 12 ) ) -RRB- cord-015021-pol2qm74 1659 13 , , , cord-015021-pol2qm74 1659 14 second second JJ cord-015021-pol2qm74 1659 15 fraction fraction NN cord-015021-pol2qm74 1659 16 on on IN cord-015021-pol2qm74 1659 17 secretion secretion NN cord-015021-pol2qm74 1659 18 of of IN cord-015021-pol2qm74 1659 19 lysosomal lysosomal JJ cord-015021-pol2qm74 1659 20 enzymes enzyme NNS cord-015021-pol2qm74 1659 21 by by IN cord-015021-pol2qm74 1659 22 murine murine JJ cord-015021-pol2qm74 1659 23 peritoneal peritoneal JJ cord-015021-pol2qm74 1659 24 macrophages macrophage NNS cord-015021-pol2qm74 1659 25 was be VBD cord-015021-pol2qm74 1659 26 studied study VBN cord-015021-pol2qm74 1659 27 . . . cord-015021-pol2qm74 1660 1 Zymosan Zymosan NNP cord-015021-pol2qm74 1660 2 increased increase VBD cord-015021-pol2qm74 1660 3 the the DT cord-015021-pol2qm74 1660 4 secretion secretion NN cord-015021-pol2qm74 1660 5 of of IN cord-015021-pol2qm74 1660 6 N n CD cord-015021-pol2qm74 1660 7 - - HYPH cord-015021-pol2qm74 1660 8 acetyl-~-D acetyl-~-D NNP cord-015021-pol2qm74 1660 9 - - HYPH cord-015021-pol2qm74 1660 10 glucosaminidase glucosaminidase NN cord-015021-pol2qm74 1660 11 and and CC cord-015021-pol2qm74 1660 12 ~-galactosidase ~-galactosidase NFP cord-015021-pol2qm74 1660 13 into into IN cord-015021-pol2qm74 1660 14 the the DT cord-015021-pol2qm74 1660 15 culture culture NN cord-015021-pol2qm74 1660 16 medium medium NN cord-015021-pol2qm74 1660 17 ( ( -LRB- cord-015021-pol2qm74 1660 18 3 3 CD cord-015021-pol2qm74 1660 19 - - SYM cord-015021-pol2qm74 1660 20 4 4 CD cord-015021-pol2qm74 1660 21 fold fold NN cord-015021-pol2qm74 1660 22 ) ) -RRB- cord-015021-pol2qm74 1660 23 ; ; : cord-015021-pol2qm74 1660 24 BCG BCG NNP cord-015021-pol2qm74 1660 25 possessed possess VBD cord-015021-pol2qm74 1660 26 similar similar JJ cord-015021-pol2qm74 1660 27 effect effect NN cord-015021-pol2qm74 1660 28 . . . cord-015021-pol2qm74 1661 1 CMG CMG NNP cord-015021-pol2qm74 1661 2 in in IN cord-015021-pol2qm74 1661 3 the the DT cord-015021-pol2qm74 1661 4 same same JJ cord-015021-pol2qm74 1661 5 concentrations concentration NNS cord-015021-pol2qm74 1661 6 ( ( -LRB- cord-015021-pol2qm74 1661 7 50 50 CD cord-015021-pol2qm74 1661 8 /~g /~g , cord-015021-pol2qm74 1661 9 / / SYM cord-015021-pol2qm74 1661 10 ml ml NN cord-015021-pol2qm74 1661 11 ) ) -RRB- cord-015021-pol2qm74 1661 12 increased increase VBN cord-015021-pol2qm74 1661 13 release release NN cord-015021-pol2qm74 1661 14 of of IN cord-015021-pol2qm74 1661 15 these these DT cord-015021-pol2qm74 1661 16 enzymes enzyme NNS cord-015021-pol2qm74 1662 1 only only RB cord-015021-pol2qm74 1662 2 sAightly sAightly NNP cord-015021-pol2qm74 1662 3 ( ( -LRB- cord-015021-pol2qm74 1662 4 1.6 1.6 CD cord-015021-pol2qm74 1662 5 times).It times).it NN cord-015021-pol2qm74 1662 6 's be VBZ cord-015021-pol2qm74 1662 7 known know VBN cord-015021-pol2qm74 1662 8 that that IN cord-015021-pol2qm74 1662 9 zymosan zymosan NN cord-015021-pol2qm74 1662 10 - - HYPH cord-015021-pol2qm74 1662 11 induced induce VBN cord-015021-pol2qm74 1662 12 secretion secretion NN cord-015021-pol2qm74 1662 13 reflects reflect VBZ cord-015021-pol2qm74 1662 14 the the DT cord-015021-pol2qm74 1662 15 enzyme enzyme NN cord-015021-pol2qm74 1662 16 release release NN cord-015021-pol2qm74 1662 17 from from IN cord-015021-pol2qm74 1662 18 formed form VBN cord-015021-pol2qm74 1662 19 lysosomes lysosome NNS cord-015021-pol2qm74 1662 20 ( ( -LRB- cord-015021-pol2qm74 1662 21 Warren,1989 Warren,1989 NNP cord-015021-pol2qm74 1662 22 ) ) -RRB- cord-015021-pol2qm74 1662 23 .It .It . cord-015021-pol2qm74 1663 1 was be VBD cord-015021-pol2qm74 1663 2 suggested suggest VBN cord-015021-pol2qm74 1663 3 that that IN cord-015021-pol2qm74 1663 4 CMG CMG NNP cord-015021-pol2qm74 1663 5 activated activate VBD cord-015021-pol2qm74 1663 6 macrophages macrophage NNS cord-015021-pol2qm74 1663 7 via via IN cord-015021-pol2qm74 1663 8 interaction interaction NN cord-015021-pol2qm74 1663 9 with with IN cord-015021-pol2qm74 1663 10 scavenger scavenger NN cord-015021-pol2qm74 1663 11 - - HYPH cord-015021-pol2qm74 1663 12 receptors receptor NNS cord-015021-pol2qm74 1663 13 , , , cord-015021-pol2qm74 1663 14 followed follow VBN cord-015021-pol2qm74 1663 15 by by IN cord-015021-pol2qm74 1663 16 weak weak JJ cord-015021-pol2qm74 1663 17 secretion secretion NN cord-015021-pol2qm74 1663 18 of of IN cord-015021-pol2qm74 1663 19 lysosomal lysosomal JJ cord-015021-pol2qm74 1663 20 enzymes enzyme NNS cord-015021-pol2qm74 1663 21 and and CC cord-015021-pol2qm74 1663 22 as as IN cord-015021-pol2qm74 1663 23 a a DT cord-015021-pol2qm74 1663 24 result result NN cord-015021-pol2qm74 1663 25 decrease decrease NN cord-015021-pol2qm74 1663 26 of of IN cord-015021-pol2qm74 1663 27 tissue tissue NN cord-015021-pol2qm74 1663 28 damage damage NN cord-015021-pol2qm74 1663 29 . . . cord-015021-pol2qm74 1664 1 In in IN cord-015021-pol2qm74 1664 2 vivo vivo NNP cord-015021-pol2qm74 1664 3 zymosan zymosan NNP cord-015021-pol2qm74 1664 4 induced induce VBD cord-015021-pol2qm74 1664 5 stimulation stimulation NN cord-015021-pol2qm74 1664 6 of of IN cord-015021-pol2qm74 1664 7 mononuclear mononuclear JJ cord-015021-pol2qm74 1664 8 system system NN cord-015021-pol2qm74 1664 9 of of IN cord-015021-pol2qm74 1664 10 phagocytes phagocyte NNS cord-015021-pol2qm74 1664 11 followed follow VBN cord-015021-pol2qm74 1664 12 by by IN cord-015021-pol2qm74 1664 13 increase increase NN cord-015021-pol2qm74 1664 14 of of IN cord-015021-pol2qm74 1664 15 cysteine cysteine NN cord-015021-pol2qm74 1664 16 proteinases proteinases NNP cord-015021-pol2qm74 1664 17 activity activity NN cord-015021-pol2qm74 1664 18 in in IN cord-015021-pol2qm74 1664 19 liver liver NN cord-015021-pol2qm74 1664 20 at at IN cord-015021-pol2qm74 1664 21 the the DT cord-015021-pol2qm74 1664 22 5th 5th JJ cord-015021-pol2qm74 1664 23 day day NN cord-015021-pol2qm74 1664 24 . . . cord-015021-pol2qm74 1665 1 In in IN cord-015021-pol2qm74 1665 2 the the DT cord-015021-pol2qm74 1665 3 same same JJ cord-015021-pol2qm74 1665 4 time time NN cord-015021-pol2qm74 1665 5 in in IN cord-015021-pol2qm74 1665 6 blood blood NN cord-015021-pol2qm74 1665 7 N n CD cord-015021-pol2qm74 1665 8 - - HYPH cord-015021-pol2qm74 1665 9 acetyl-~-D acetyl-~-D NNP cord-015021-pol2qm74 1665 10 - - HYPH cord-015021-pol2qm74 1665 11 glucosaminidase glucosaminidase NN cord-015021-pol2qm74 1665 12 and and CC cord-015021-pol2qm74 1665 13 N N NNP cord-015021-pol2qm74 1665 14 - - HYPH cord-015021-pol2qm74 1665 15 acetyl-~-D acetyl-~-d NN cord-015021-pol2qm74 1665 16 - - HYPH cord-015021-pol2qm74 1665 17 galactosidase galactosidase NN cord-015021-pol2qm74 1665 18 activity activity NN cord-015021-pol2qm74 1665 19 increased increase VBD cord-015021-pol2qm74 1665 20 2 2 CD cord-015021-pol2qm74 1665 21 - - SYM cord-015021-pol2qm74 1665 22 5 5 CD cord-015021-pol2qm74 1665 23 fold fold NN cord-015021-pol2qm74 1665 24 . . . cord-015021-pol2qm74 1666 1 It -PRON- PRP cord-015021-pol2qm74 1666 2 was be VBD cord-015021-pol2qm74 1666 3 concluded conclude VBN cord-015021-pol2qm74 1666 4 that that IN cord-015021-pol2qm74 1666 5 in in IN cord-015021-pol2qm74 1666 6 drug drug NN cord-015021-pol2qm74 1666 7 design design NN cord-015021-pol2qm74 1666 8 it -PRON- PRP cord-015021-pol2qm74 1666 9 's be VBZ cord-015021-pol2qm74 1666 10 possible possible JJ cord-015021-pol2qm74 1666 11 to to TO cord-015021-pol2qm74 1666 12 select select VB cord-015021-pol2qm74 1666 13 such such JJ cord-015021-pol2qm74 1666 14 immunomodulators immunomodulator NNS cord-015021-pol2qm74 1666 15 , , , cord-015021-pol2qm74 1666 16 e.g e.g NNP cord-015021-pol2qm74 1666 17 . . NNP cord-015021-pol2qm74 1666 18 CMG CMG NNP cord-015021-pol2qm74 1666 19 , , , cord-015021-pol2qm74 1666 20 which which WDT cord-015021-pol2qm74 1666 21 can can MD cord-015021-pol2qm74 1666 22 activate activate VB cord-015021-pol2qm74 1666 23 mononuclear mononuclear JJ cord-015021-pol2qm74 1666 24 system system NN cord-015021-pol2qm74 1666 25 of of IN cord-015021-pol2qm74 1666 26 phagocytes phagocyte NNS cord-015021-pol2qm74 1666 27 and and CC cord-015021-pol2qm74 1666 28 do do VBP cord-015021-pol2qm74 1666 29 not not RB cord-015021-pol2qm74 1666 30 damage damage VB cord-015021-pol2qm74 1666 31 tissue tissue NN cord-015021-pol2qm74 1666 32 . . . cord-015021-pol2qm74 1667 1 Endothelin Endothelin NNP cord-015021-pol2qm74 1667 2 - - HYPH cord-015021-pol2qm74 1667 3 i i NNP cord-015021-pol2qm74 1667 4 ( ( -LRB- cord-015021-pol2qm74 1667 5 ET et NN cord-015021-pol2qm74 1667 6 - - HYPH cord-015021-pol2qm74 1667 7 I I NNP cord-015021-pol2qm74 1667 8 ) ) -RRB- cord-015021-pol2qm74 1667 9 is be VBZ cord-015021-pol2qm74 1667 10 produced produce VBN cord-015021-pol2qm74 1667 11 by by IN cord-015021-pol2qm74 1667 12 injured/ injured/ NN cord-015021-pol2qm74 1667 13 ischemic ischemic JJ cord-015021-pol2qm74 1667 14 endothelium endothelium NN cord-015021-pol2qm74 1667 15 , , , cord-015021-pol2qm74 1667 16 mobilizes mobilize VBZ cord-015021-pol2qm74 1667 17 intracellular intracellular JJ cord-015021-pol2qm74 1667 18 Ca Ca NNP cord-015021-pol2qm74 1667 19 + + CC cord-015021-pol2qm74 1668 1 + + CC cord-015021-pol2qm74 1668 2 and and CC cord-015021-pol2qm74 1668 3 is be VBZ cord-015021-pol2qm74 1668 4 a a DT cord-015021-pol2qm74 1668 5 potent potent JJ cord-015021-pol2qm74 1668 6 vasoconstrictor vasoconstrictor NN cord-015021-pol2qm74 1668 7 . . . cord-015021-pol2qm74 1669 1 It -PRON- PRP cord-015021-pol2qm74 1669 2 is be VBZ cord-015021-pol2qm74 1669 3 also also RB cord-015021-pol2qm74 1669 4 a a DT cord-015021-pol2qm74 1669 5 Ca Ca NNP cord-015021-pol2qm74 1669 6 + + CC cord-015021-pol2qm74 1669 7 + + CC cord-015021-pol2qm74 1669 8 agonist agonist NN cord-015021-pol2qm74 1669 9 for for IN cord-015021-pol2qm74 1669 10 anterior anterior JJ cord-015021-pol2qm74 1669 11 pituitary pituitary NN cord-015021-pol2qm74 1669 12 or or CC cord-015021-pol2qm74 1669 13 renal renal JJ cord-015021-pol2qm74 1669 14 mesangial mesangial JJ cord-015021-pol2qm74 1669 15 cells cell NNS cord-015021-pol2qm74 1669 16 and and CC cord-015021-pol2qm74 1669 17 monocytes monocyte NNS cord-015021-pol2qm74 1669 18 . . . cord-015021-pol2qm74 1670 1 ET ET NNP cord-015021-pol2qm74 1670 2 - - HYPH cord-015021-pol2qm74 1670 3 I -PRON- PRP cord-015021-pol2qm74 1670 4 causes cause VBZ cord-015021-pol2qm74 1670 5 monocytes monocyte NNS cord-015021-pol2qm74 1670 6 to to TO cord-015021-pol2qm74 1670 7 produce produce VB cord-015021-pol2qm74 1670 8 interleukin interleukin NN cord-015021-pol2qm74 1670 9 - - HYPH cord-015021-pol2qm74 1670 10 l l NN cord-015021-pol2qm74 1670 11 , , , cord-015021-pol2qm74 1670 12 6 6 CD cord-015021-pol2qm74 1670 13 , , , cord-015021-pol2qm74 1670 14 8 8 CD cord-015021-pol2qm74 1670 15 , , , cord-015021-pol2qm74 1670 16 prostaglandin prostaglandin NN cord-015021-pol2qm74 1670 17 E2 e2 NN cord-015021-pol2qm74 1670 18 , , , cord-015021-pol2qm74 1670 19 and and CC cord-015021-pol2qm74 1670 20 substances substance NNS cord-015021-pol2qm74 1670 21 which which WDT cord-015021-pol2qm74 1670 22 trigger trigger VBP cord-015021-pol2qm74 1670 23 neutrophil neutrophil NN cord-015021-pol2qm74 1670 24 superoxide superoxide NN cord-015021-pol2qm74 1670 25 production production NN cord-015021-pol2qm74 1670 26 . . . cord-015021-pol2qm74 1671 1 ET- ET- NNP cord-015021-pol2qm74 1672 1 I -PRON- PRP cord-015021-pol2qm74 1672 2 levels level NNS cord-015021-pol2qm74 1672 3 increase increase VBP cord-015021-pol2qm74 1672 4 in in IN cord-015021-pol2qm74 1672 5 shock shock NN cord-015021-pol2qm74 1672 6 and and CC cord-015021-pol2qm74 1672 7 ET ET NNP cord-015021-pol2qm74 1672 8 may may MD cord-015021-pol2qm74 1672 9 play play VB cord-015021-pol2qm74 1672 10 a a DT cord-015021-pol2qm74 1672 11 role role NN cord-015021-pol2qm74 1672 12 in in IN cord-015021-pol2qm74 1672 13 activating activate VBG cord-015021-pol2qm74 1672 14 leukocytes leukocyte NNS cord-015021-pol2qm74 1672 15 post post NN cord-015021-pol2qm74 1672 16 shock shock NN cord-015021-pol2qm74 1672 17 causing cause VBG cord-015021-pol2qm74 1672 18 reperfusion reperfusion NN cord-015021-pol2qm74 1672 19 injury injury NN cord-015021-pol2qm74 1672 20 . . . cord-015021-pol2qm74 1673 1 But but CC cord-015021-pol2qm74 1673 2 blood blood NN cord-015021-pol2qm74 1673 3 flow flow NN cord-015021-pol2qm74 1673 4 experiments experiment NNS cord-015021-pol2qm74 1673 5 suggest suggest VBP cord-015021-pol2qm74 1673 6 splanchnic splanchnic JJ cord-015021-pol2qm74 1673 7 circulation circulation NN cord-015021-pol2qm74 1673 8 changes change NNS cord-015021-pol2qm74 1673 9 more more RBR cord-015021-pol2qm74 1673 10 profoundly profoundly RB cord-015021-pol2qm74 1673 11 in in IN cord-015021-pol2qm74 1673 12 shock shock NN cord-015021-pol2qm74 1673 13 than than IN cord-015021-pol2qm74 1673 14 peripheral peripheral JJ cord-015021-pol2qm74 1673 15 circulation circulation NN cord-015021-pol2qm74 1673 16 . . . cord-015021-pol2qm74 1674 1 We -PRON- PRP cord-015021-pol2qm74 1674 2 therefore therefore RB cord-015021-pol2qm74 1674 3 asked ask VBD cord-015021-pol2qm74 1674 4 if if IN cord-015021-pol2qm74 1674 5 ET-4 ET-4 NNP cord-015021-pol2qm74 1674 6 ( ( -LRB- cord-015021-pol2qm74 1674 7 or or CC cord-015021-pol2qm74 1674 8 VIC VIC NNP cord-015021-pol2qm74 1674 9 ) ) -RRB- cord-015021-pol2qm74 1674 10 , , , cord-015021-pol2qm74 1674 11 the the DT cord-015021-pol2qm74 1674 12 ET ET NNP cord-015021-pol2qm74 1674 13 which which WDT cord-015021-pol2qm74 1674 14 predominates predominate VBZ cord-015021-pol2qm74 1674 15 in in IN cord-015021-pol2qm74 1674 16 splanchnic splanchnic JJ cord-015021-pol2qm74 1674 17 vessels vessel NNS cord-015021-pol2qm74 1674 18 , , , cord-015021-pol2qm74 1674 19 had have VBD cord-015021-pol2qm74 1674 20 any any DT cord-015021-pol2qm74 1674 21 effect effect NN cord-015021-pol2qm74 1674 22 on on IN cord-015021-pol2qm74 1674 23 monocyte monocyte NNP cord-015021-pol2qm74 1674 24 cytokine cytokine NN cord-015021-pol2qm74 1674 25 production production NN cord-015021-pol2qm74 1674 26 . . . cord-015021-pol2qm74 1675 1 Human human JJ cord-015021-pol2qm74 1675 2 monocytes monocyte NNS cord-015021-pol2qm74 1675 3 from from IN cord-015021-pol2qm74 1675 4 health~ health~ NNP cord-015021-pol2qm74 1675 5 blood blood NN cord-015021-pol2qm74 1675 6 donors donor NNS cord-015021-pol2qm74 1675 7 were be VBD cord-015021-pol2qm74 1675 8 separated separate VBN cord-015021-pol2qm74 1675 9 on on IN cord-015021-pol2qm74 1675 10 Ficoll Ficoll NNP cord-015021-pol2qm74 1675 11 . . . cord-015021-pol2qm74 1676 1 0.5 0.5 CD cord-015021-pol2qm74 1676 2 x x SYM cord-015021-pol2qm74 1676 3 10Ucells/ 10ucells/ CD cord-015021-pol2qm74 1676 4 ml ml NNS cord-015021-pol2qm74 1676 5 in in IN cord-015021-pol2qm74 1676 6 RPMI RPMI NNP cord-015021-pol2qm74 1677 1 1640 1640 CD cord-015021-pol2qm74 1678 1 + + CC cord-015021-pol2qm74 1679 1 10 10 CD cord-015021-pol2qm74 1679 2 % % NN cord-015021-pol2qm74 1679 3 FCS FCS NNP cord-015021-pol2qm74 1679 4 were be VBD cord-015021-pol2qm74 1679 5 incubated incubate VBN cord-015021-pol2qm74 1679 6 i0 i0 NNP cord-015021-pol2qm74 1679 7 min min NNP cord-015021-pol2qm74 1679 8 . . . cord-015021-pol2qm74 1680 1 , , , cord-015021-pol2qm74 1680 2 6 6 CD cord-015021-pol2qm74 1680 3 & & CC cord-015021-pol2qm74 1680 4 24 24 CD cord-015021-pol2qm74 1680 5 hrs hrs NN cord-015021-pol2qm74 1680 6 . . . cord-015021-pol2qm74 1681 1 with with IN cord-015021-pol2qm74 1681 2 10 10 CD cord-015021-pol2qm74 1681 3 -8 -8 NNP cord-015021-pol2qm74 1681 4 M M NNP cord-015021-pol2qm74 1681 5 ET et NN cord-015021-pol2qm74 1681 6 - - HYPH cord-015021-pol2qm74 1681 7 I I NNP cord-015021-pol2qm74 1681 8 , , , cord-015021-pol2qm74 1681 9 10 10 CD cord-015021-pol2qm74 1681 10 -8 -8 NNP cord-015021-pol2qm74 1681 11 M M NNP cord-015021-pol2qm74 1681 12 VIC VIC NNP cord-015021-pol2qm74 1681 13 or or CC cord-015021-pol2qm74 1681 14 I0 I0 NNP cord-015021-pol2qm74 1681 15 ug ug NNP cord-015021-pol2qm74 1681 16 / / SYM cord-015021-pol2qm74 1681 17 ml ml NN cord-015021-pol2qm74 1681 18 of of IN cord-015021-pol2qm74 1681 19 LPS LPS NNP cord-015021-pol2qm74 1681 20 . . . cord-015021-pol2qm74 1682 1 Supernatants supernatant NNS cord-015021-pol2qm74 1682 2 were be VBD cord-015021-pol2qm74 1682 3 assayed assay VBN cord-015021-pol2qm74 1682 4 by by IN cord-015021-pol2qm74 1682 5 ELISA ELISA NNP cord-015021-pol2qm74 1682 6 . . . cord-015021-pol2qm74 1683 1 We -PRON- PRP cord-015021-pol2qm74 1683 2 have have VBP cord-015021-pol2qm74 1683 3 shown show VBN cord-015021-pol2qm74 1683 4 that that IN cord-015021-pol2qm74 1683 5 low low JJ cord-015021-pol2qm74 1683 6 dose dose NN cord-015021-pol2qm74 1683 7 endotoxin endotoxin NN cord-015021-pol2qm74 1683 8 pretreatment pretreatment NN cord-015021-pol2qm74 1683 9 ( ( -LRB- cord-015021-pol2qm74 1683 10 LPS LPS NNP cord-015021-pol2qm74 1683 11 1 1 CD cord-015021-pol2qm74 1683 12 ) ) -RRB- cord-015021-pol2qm74 1683 13 for for IN cord-015021-pol2qm74 1683 14 24 24 CD cord-015021-pol2qm74 1683 15 hrs hrs NN cord-015021-pol2qm74 1683 16 markedly markedly RB cord-015021-pol2qm74 1683 17 inhibits inhibit VBZ cord-015021-pol2qm74 1683 18 the the DT cord-015021-pol2qm74 1683 19 macrophage macrophage NN cord-015021-pol2qm74 1683 20 ( ( -LRB- cord-015021-pol2qm74 1683 21 MO MO NNP cord-015021-pol2qm74 1683 22 ) ) -RRB- cord-015021-pol2qm74 1683 23 release release NN cord-015021-pol2qm74 1683 24 of of IN cord-015021-pol2qm74 1683 25 tumor tumor NN cord-015021-pol2qm74 1683 26 necrosis necrosis NN cord-015021-pol2qm74 1683 27 factor factor NN cord-015021-pol2qm74 1683 28 ( ( -LRB- cord-015021-pol2qm74 1683 29 TNF TNF NNP cord-015021-pol2qm74 1683 30 ) ) -RRB- cord-015021-pol2qm74 1683 31 and and CC cord-015021-pol2qm74 1683 32 increases increase VBZ cord-015021-pol2qm74 1683 33 interleukin-1 interleukin-1 NNP cord-015021-pol2qm74 1683 34 ( ( -LRB- cord-015021-pol2qm74 1683 35 IL IL NNP cord-015021-pol2qm74 1683 36 - - HYPH cord-015021-pol2qm74 1683 37 I I NNP cord-015021-pol2qm74 1683 38 ) ) -RRB- cord-015021-pol2qm74 1683 39 in in IN cord-015021-pol2qm74 1683 40 response response NN cord-015021-pol2qm74 1683 41 to to IN cord-015021-pol2qm74 1683 42 a a DT cord-015021-pol2qm74 1683 43 subsequent subsequent JJ cord-015021-pol2qm74 1683 44 endotoxin endotoxin NN cord-015021-pol2qm74 1683 45 stimulus stimulus NN cord-015021-pol2qm74 1683 46 ( ( -LRB- cord-015021-pol2qm74 1683 47 LPS2 LPS2 NNP cord-015021-pol2qm74 1683 48 ) ) -RRB- cord-015021-pol2qm74 1683 49 . . . cord-015021-pol2qm74 1684 1 In in IN cord-015021-pol2qm74 1684 2 this this DT cord-015021-pol2qm74 1684 3 study study NN cord-015021-pol2qm74 1684 4 we -PRON- PRP cord-015021-pol2qm74 1684 5 examined examine VBD cord-015021-pol2qm74 1684 6 the the DT cord-015021-pol2qm74 1684 7 kinetics kinetic NNS cord-015021-pol2qm74 1684 8 of of IN cord-015021-pol2qm74 1684 9 LPS LPS NNP cord-015021-pol2qm74 1684 10 1 1 CD cord-015021-pol2qm74 1684 11 inhibition inhibition NN cord-015021-pol2qm74 1684 12 of of IN cord-015021-pol2qm74 1684 13 TNF TNF NNP cord-015021-pol2qm74 1684 14 and and CC cord-015021-pol2qm74 1684 15 augmentation augmentation NN cord-015021-pol2qm74 1684 16 ofIL-1 ofil-1 CD cord-015021-pol2qm74 1684 17 . . . cord-015021-pol2qm74 1685 1 Methods method NNS cord-015021-pol2qm74 1685 2 : : : cord-015021-pol2qm74 1686 1 Murine murine JJ cord-015021-pol2qm74 1686 2 peritoneal peritoneal NN cord-015021-pol2qm74 1686 3 exudate exudate NN cord-015021-pol2qm74 1686 4 MO MO NNP cord-015021-pol2qm74 1686 5 from from IN cord-015021-pol2qm74 1686 6 Balbc Balbc NNP cord-015021-pol2qm74 1686 7 mice mouse NNS cord-015021-pol2qm74 1686 8 were be VBD cord-015021-pol2qm74 1686 9 exposed expose VBN cord-015021-pol2qm74 1686 10 in in IN cord-015021-pol2qm74 1686 11 vitro vitro FW cord-015021-pol2qm74 1686 12 to to IN cord-015021-pol2qm74 1686 13 medium medium NN cord-015021-pol2qm74 1686 14 or or CC cord-015021-pol2qm74 1686 15 10 10 CD cord-015021-pol2qm74 1686 16 ng ng NN cord-015021-pol2qm74 1686 17 / / SYM cord-015021-pol2qm74 1686 18 ml ml NN cord-015021-pol2qm74 1686 19 of of IN cord-015021-pol2qm74 1686 20 LPS1 LPS1 NNP cord-015021-pol2qm74 1686 21 for for IN cord-015021-pol2qm74 1686 22 intervals interval NNS cord-015021-pol2qm74 1686 23 of of IN cord-015021-pol2qm74 1686 24 0 0 CD cord-015021-pol2qm74 1686 25 to to TO cord-015021-pol2qm74 1686 26 24 24 CD cord-015021-pol2qm74 1686 27 hours hour NNS cord-015021-pol2qm74 1686 28 . . . cord-015021-pol2qm74 1687 1 Culture culture NN cord-015021-pol2qm74 1687 2 medium medium NN cord-015021-pol2qm74 1687 3 was be VBD cord-015021-pol2qm74 1687 4 then then RB cord-015021-pol2qm74 1687 5 replaced replace VBN cord-015021-pol2qm74 1687 6 with with IN cord-015021-pol2qm74 1687 7 0 0 CD cord-015021-pol2qm74 1687 8 , , , cord-015021-pol2qm74 1687 9 10 10 CD cord-015021-pol2qm74 1687 10 or or CC cord-015021-pol2qm74 1687 11 1000 1000 CD cord-015021-pol2qm74 1687 12 ng ng NN cord-015021-pol2qm74 1687 13 / / SYM cord-015021-pol2qm74 1687 14 ml ml NN cord-015021-pol2qm74 1687 15 of of IN cord-015021-pol2qm74 1687 16 LPS2 LPS2 NNP cord-015021-pol2qm74 1687 17 for for IN cord-015021-pol2qm74 1687 18 24 24 CD cord-015021-pol2qm74 1687 19 hrs hrs NN cord-015021-pol2qm74 1687 20 . . . cord-015021-pol2qm74 1688 1 TNF TNF NNP cord-015021-pol2qm74 1688 2 and and CC cord-015021-pol2qm74 1688 3 IL-1 IL-1 NNP cord-015021-pol2qm74 1688 4 in in IN cord-015021-pol2qm74 1688 5 MO MO NNP cord-015021-pol2qm74 1688 6 supernatants supernatant NNS cord-015021-pol2qm74 1688 7 were be VBD cord-015021-pol2qm74 1688 8 measured measure VBN cord-015021-pol2qm74 1688 9 by by IN cord-015021-pol2qm74 1688 10 specific specific JJ cord-015021-pol2qm74 1688 11 bioassays bioassay NNS cord-015021-pol2qm74 1688 12 . . . cord-015021-pol2qm74 1689 1 During during IN cord-015021-pol2qm74 1689 2 sepsis sepsis NN cord-015021-pol2qm74 1689 3 endotoxin endotoxin NN cord-015021-pol2qm74 1689 4 ( ( -LRB- cord-015021-pol2qm74 1689 5 LPS LPS NNP cord-015021-pol2qm74 1689 6 ) ) -RRB- cord-015021-pol2qm74 1689 7 activates activate VBZ cord-015021-pol2qm74 1689 8 macrophages macrophage NNS cord-015021-pol2qm74 1689 9 ( ( -LRB- cord-015021-pol2qm74 1689 10 MO MO NNP cord-015021-pol2qm74 1689 11 ) ) -RRB- cord-015021-pol2qm74 1689 12 to to TO cord-015021-pol2qm74 1689 13 release release VB cord-015021-pol2qm74 1689 14 mediators mediator NNS cord-015021-pol2qm74 1689 15 such such JJ cord-015021-pol2qm74 1689 16 as as IN cord-015021-pol2qm74 1689 17 tumor tumor NN cord-015021-pol2qm74 1689 18 necrosis necrosis NN cord-015021-pol2qm74 1689 19 factor factor NN cord-015021-pol2qm74 1689 20 ( ( -LRB- cord-015021-pol2qm74 1689 21 TNF TNF NNP cord-015021-pol2qm74 1689 22 ) ) -RRB- cord-015021-pol2qm74 1689 23 , , . cord-015021-pol2qm74 1690 1 interleukin-6 interleukin-6 NNP cord-015021-pol2qm74 1690 2 ( ( -LRB- cord-015021-pol2qm74 1690 3 IL-6 IL-6 NNP cord-015021-pol2qm74 1690 4 ) ) -RRB- cord-015021-pol2qm74 1690 5 , , , cord-015021-pol2qm74 1690 6 interleukin interleukin NN cord-015021-pol2qm74 1690 7 - - : cord-015021-pol2qm74 1690 8 I i NN cord-015021-pol2qm74 1690 9 ( ( -LRB- cord-015021-pol2qm74 1690 10 IL IL NNP cord-015021-pol2qm74 1690 11 - - HYPH cord-015021-pol2qm74 1690 12 I I NNP cord-015021-pol2qm74 1690 13 ) ) -RRB- cord-015021-pol2qm74 1690 14 and and CC cord-015021-pol2qm74 1690 15 prostaglandin prostaglandin NN cord-015021-pol2qm74 1690 16 E2 e2 NN cord-015021-pol2qm74 1690 17 ( ( -LRB- cord-015021-pol2qm74 1690 18 PGE2 PGE2 NNP cord-015021-pol2qm74 1690 19 ) ) -RRB- cord-015021-pol2qm74 1690 20 . . . cord-015021-pol2qm74 1691 1 We -PRON- PRP cord-015021-pol2qm74 1691 2 showed show VBD cord-015021-pol2qm74 1691 3 that that IN cord-015021-pol2qm74 1691 4 preexposure preexposure NN cord-015021-pol2qm74 1691 5 to to IN cord-015021-pol2qm74 1691 6 LPS LPS NNP cord-015021-pol2qm74 1691 7 ( ( -LRB- cord-015021-pol2qm74 1691 8 LPS LPS NNP cord-015021-pol2qm74 1691 9 1 1 CD cord-015021-pol2qm74 1691 10 ) ) -RRB- cord-015021-pol2qm74 1691 11 alters alter VBZ cord-015021-pol2qm74 1691 12 the the DT cord-015021-pol2qm74 1691 13 response response NN cord-015021-pol2qm74 1691 14 of of IN cord-015021-pol2qm74 1691 15 murine murine JJ cord-015021-pol2qm74 1691 16 M M NNP cord-015021-pol2qm74 1691 17 ~ ~ NFP cord-015021-pol2qm74 1691 18 i i NN cord-015021-pol2qm74 1691 19 to to IN cord-015021-pol2qm74 1691 20 subsequent subsequent JJ cord-015021-pol2qm74 1691 21 LPS LPS NNP cord-015021-pol2qm74 1691 22 stimulation stimulation NN cord-015021-pol2qm74 1691 23 ( ( -LRB- cord-015021-pol2qm74 1691 24 LPS2 LPS2 NNP cord-015021-pol2qm74 1691 25 ) ) -RRB- cord-015021-pol2qm74 1691 26 . . . cord-015021-pol2qm74 1692 1 We -PRON- PRP cord-015021-pol2qm74 1692 2 hypothesized hypothesize VBD cord-015021-pol2qm74 1692 3 that that IN cord-015021-pol2qm74 1692 4 in in IN cord-015021-pol2qm74 1692 5 vitro vitro FW cord-015021-pol2qm74 1692 6 cytokine cytokine NN cord-015021-pol2qm74 1692 7 release release NN cord-015021-pol2qm74 1692 8 by by IN cord-015021-pol2qm74 1692 9 LPS2 LPS2 NNP cord-015021-pol2qm74 1692 10 in in IN cord-015021-pol2qm74 1692 11 human human JJ cord-015021-pol2qm74 1692 12 monocytes monocyte NNS cord-015021-pol2qm74 1692 13 ( ( -LRB- cord-015021-pol2qm74 1692 14 MO MO NNP cord-015021-pol2qm74 1692 15 ) ) -RRB- cord-015021-pol2qm74 1692 16 is be VBZ cord-015021-pol2qm74 1692 17 also also RB cord-015021-pol2qm74 1692 18 be be VB cord-015021-pol2qm74 1692 19 altered alter VBN cord-015021-pol2qm74 1692 20 by by IN cord-015021-pol2qm74 1692 21 preexposure preexposure NN cord-015021-pol2qm74 1692 22 to to IN cord-015021-pol2qm74 1692 23 LPSI LPSI NNP cord-015021-pol2qm74 1692 24 . . . cord-015021-pol2qm74 1693 1 Methods method NNS cord-015021-pol2qm74 1693 2 : : : cord-015021-pol2qm74 1694 1 Human human JJ cord-015021-pol2qm74 1694 2 peripheral peripheral JJ cord-015021-pol2qm74 1694 3 blood blood NN cord-015021-pol2qm74 1694 4 MO MO NNP cord-015021-pol2qm74 1694 5 were be VBD cord-015021-pol2qm74 1694 6 obtained obtain VBN cord-015021-pol2qm74 1694 7 from from IN cord-015021-pol2qm74 1694 8 healthy healthy JJ cord-015021-pol2qm74 1694 9 volunteers volunteer NNS cord-015021-pol2qm74 1694 10 ( ( -LRB- cord-015021-pol2qm74 1694 11 N=8 N=8 NNP cord-015021-pol2qm74 1694 12 ) ) -RRB- cord-015021-pol2qm74 1694 13 , , , cord-015021-pol2qm74 1694 14 cultured culture VBN cord-015021-pol2qm74 1694 15 in in IN cord-015021-pol2qm74 1694 16 vitro vitro JJ cord-015021-pol2qm74 1694 17 24 24 CD cord-015021-pol2qm74 1694 18 hrs hrs NN cord-015021-pol2qm74 1694 19 , , , cord-015021-pol2qm74 1694 20 then then RB cord-015021-pol2qm74 1694 21 pretreated pretreate VBD cord-015021-pol2qm74 1694 22 24 24 CD cord-015021-pol2qm74 1694 23 hr hr NN cord-015021-pol2qm74 1694 24 _ _ NN cord-015021-pol2qm74 1695 1 + + CC cord-015021-pol2qm74 1695 2 LPS LPS NNP cord-015021-pol2qm74 1695 3 1-Cultures 1-Cultures NNPS cord-015021-pol2qm74 1695 4 were be VBD cord-015021-pol2qm74 1695 5 then then RB cord-015021-pol2qm74 1695 6 stimulated stimulate VBN cord-015021-pol2qm74 1695 7 with with IN cord-015021-pol2qm74 1695 8 LPS LPS NNP cord-015021-pol2qm74 1695 9 2 2 CD cord-015021-pol2qm74 1695 10 and and CC cord-015021-pol2qm74 1695 11 mediators mediator NNS cord-015021-pol2qm74 1695 12 in in IN cord-015021-pol2qm74 1695 13 MO MO NNP cord-015021-pol2qm74 1695 14 supernatant supernatant NN cord-015021-pol2qm74 1695 15 measured measure VBN cord-015021-pol2qm74 1695 16 : : : cord-015021-pol2qm74 1695 17 TNF TNF NNP cord-015021-pol2qm74 1695 18 , , , cord-015021-pol2qm74 1695 19 IL IL NNP cord-015021-pol2qm74 1695 20 - - HYPH cord-015021-pol2qm74 1695 21 I I NNP cord-015021-pol2qm74 1695 22 , , , cord-015021-pol2qm74 1695 23 and and CC cord-015021-pol2qm74 1695 24 IL-6 IL-6 NNP cord-015021-pol2qm74 1695 25 by by IN cord-015021-pol2qm74 1695 26 specific specific JJ cord-015021-pol2qm74 1695 27 bioassays bioassay NNS cord-015021-pol2qm74 1695 28 , , , cord-015021-pol2qm74 1695 29 PGE2 PGE2 NNP cord-015021-pol2qm74 1695 30 by by IN cord-015021-pol2qm74 1695 31 immunoassay immunoassay JJ cord-015021-pol2qm74 1695 32 kit kit NN cord-015021-pol2qm74 1695 33 . . . cord-015021-pol2qm74 1696 1 Serum serum NN cord-015021-pol2qm74 1696 2 cytokine cytokine NN cord-015021-pol2qm74 1696 3 levels level NNS cord-015021-pol2qm74 1696 4 ( ( -LRB- cord-015021-pol2qm74 1696 5 specific specific JJ cord-015021-pol2qm74 1696 6 ELISA ELISA NNP cord-015021-pol2qm74 1696 7 kits kit NNS cord-015021-pol2qm74 1696 8 ) ) -RRB- cord-015021-pol2qm74 1696 9 were be VBD cord-015021-pol2qm74 1696 10 compared compare VBN cord-015021-pol2qm74 1696 11 to to IN cord-015021-pol2qm74 1696 12 in in FW cord-015021-pol2qm74 1696 13 vitro vitro FW cord-015021-pol2qm74 1696 14 supernatant supernatant JJ cord-015021-pol2qm74 1696 15 levels level NNS cord-015021-pol2qm74 1696 16 . . . cord-015021-pol2qm74 1697 1 Data Data NNP cord-015021-pol2qm74 1697 2 is be VBZ cord-015021-pol2qm74 1697 3 expressed express VBN cord-015021-pol2qm74 1697 4 as as IN cord-015021-pol2qm74 1697 5 % % NN cord-015021-pol2qm74 1697 6 control_+SEM control_+sem NN cord-015021-pol2qm74 1697 7 , , , cord-015021-pol2qm74 1697 8 LPS2= LPS2= JJS cord-015021-pol2qm74 1697 9 1000 1000 CD cord-015021-pol2qm74 1697 10 ng ng NNP cord-015021-pol2qm74 1697 11 / / SYM cord-015021-pol2qm74 1697 12 mh mh NN cord-015021-pol2qm74 1698 1 The the DT cord-015021-pol2qm74 1698 2 table table NN cord-015021-pol2qm74 1698 3 shows show VBZ cord-015021-pol2qm74 1698 4 that that IN cord-015021-pol2qm74 1698 5 all all DT cord-015021-pol2qm74 1698 6 mediators mediator NNS cord-015021-pol2qm74 1698 7 were be VBD cord-015021-pol2qm74 1698 8 increased increase VBN cord-015021-pol2qm74 1698 9 , , , cord-015021-pol2qm74 1698 10 in in IN cord-015021-pol2qm74 1698 11 the the DT cord-015021-pol2qm74 1698 12 absence absence NN cord-015021-pol2qm74 1698 13 of of IN cord-015021-pol2qm74 1698 14 LPS LPS NNP cord-015021-pol2qm74 1698 15 1 1 CD cord-015021-pol2qm74 1698 16 . . . cord-015021-pol2qm74 1699 1 Pretreatment pretreatment NN cord-015021-pol2qm74 1699 2 with with IN cord-015021-pol2qm74 1699 3 LPS LPS NNP cord-015021-pol2qm74 1699 4 1 1 CD cord-015021-pol2qm74 1699 5 resulted result VBD cord-015021-pol2qm74 1699 6 in in IN cord-015021-pol2qm74 1699 7 complete complete JJ cord-015021-pol2qm74 1699 8 inhibition inhibition NN cord-015021-pol2qm74 1699 9 of of IN cord-015021-pol2qm74 1699 10 LPS2-triggered LPS2-triggered NNP cord-015021-pol2qm74 1699 11 TNF TNF NNP cord-015021-pol2qm74 1699 12 release release NN cord-015021-pol2qm74 1699 13 . . . cord-015021-pol2qm74 1700 1 In in IN cord-015021-pol2qm74 1700 2 contrast contrast NN cord-015021-pol2qm74 1700 3 , , , cord-015021-pol2qm74 1700 4 LPS LPS NNP cord-015021-pol2qm74 1700 5 1 1 CD cord-015021-pol2qm74 1700 6 significantly significantly RB cord-015021-pol2qm74 1700 7 increased increase VBD cord-015021-pol2qm74 1700 8 MO MO NNP cord-015021-pol2qm74 1700 9 secretion secretion NN cord-015021-pol2qm74 1700 10 of of IN cord-015021-pol2qm74 1700 11 IL-1 IL-1 NNP cord-015021-pol2qm74 1700 12 , , , cord-015021-pol2qm74 1700 13 IL-6 IL-6 NNP cord-015021-pol2qm74 1700 14 and and CC cord-015021-pol2qm74 1700 15 PGE PGE NNP cord-015021-pol2qm74 1700 16 2 2 CD cord-015021-pol2qm74 1700 17 ( ( -LRB- cord-015021-pol2qm74 1700 18 data datum NNS cord-015021-pol2qm74 1700 19 not not RB cord-015021-pol2qm74 1700 20 shown show VBN cord-015021-pol2qm74 1700 21 ) ) -RRB- cord-015021-pol2qm74 1700 22 . . . cord-015021-pol2qm74 1701 1 Serum serum NN cord-015021-pol2qm74 1701 2 cytokine cytokine NN cord-015021-pol2qm74 1701 3 levels level NNS cord-015021-pol2qm74 1701 4 were be VBD cord-015021-pol2qm74 1701 5 as as IN cord-015021-pol2qm74 1701 6 follows follow VBZ cord-015021-pol2qm74 1701 7 : : : cord-015021-pol2qm74 1702 1 TNF TNF NNP cord-015021-pol2qm74 1702 2 407_+21 407_+21 NNP cord-015021-pol2qm74 1702 3 , , , cord-015021-pol2qm74 1702 4 IL IL NNP cord-015021-pol2qm74 1702 5 - - : cord-015021-pol2qm74 1702 6 I I NNP cord-015021-pol2qm74 1702 7 241 241 CD cord-015021-pol2qm74 1702 8 + + SYM cord-015021-pol2qm74 1702 9 208 208 CD cord-015021-pol2qm74 1702 10 , , , cord-015021-pol2qm74 1702 11 and and CC cord-015021-pol2qm74 1702 12 IL-6 IL-6 NNP cord-015021-pol2qm74 1702 13 8.0-+2.5 8.0-+2.5 NNP cord-015021-pol2qm74 1702 14 ng ng NNP cord-015021-pol2qm74 1702 15 / / SYM cord-015021-pol2qm74 1702 16 ml ml NN cord-015021-pol2qm74 1702 17 . . . cord-015021-pol2qm74 1703 1 These these DT cord-015021-pol2qm74 1703 2 serum serum NN cord-015021-pol2qm74 1703 3 levels level NNS cord-015021-pol2qm74 1703 4 were be VBD cord-015021-pol2qm74 1703 5 low low JJ cord-015021-pol2qm74 1703 6 , , , cord-015021-pol2qm74 1703 7 showed show VBD cord-015021-pol2qm74 1703 8 an an DT cord-015021-pol2qm74 1703 9 extremely extremely RB cord-015021-pol2qm74 1703 10 wide wide JJ cord-015021-pol2qm74 1703 11 variation variation NN cord-015021-pol2qm74 1703 12 , , , cord-015021-pol2qm74 1703 13 and and CC cord-015021-pol2qm74 1703 14 did do VBD cord-015021-pol2qm74 1703 15 not not RB cord-015021-pol2qm74 1703 16 correlate correlate VB cord-015021-pol2qm74 1703 17 with with IN cord-015021-pol2qm74 1703 18 in in IN cord-015021-pol2qm74 1703 19 vitro vitro FW cord-015021-pol2qm74 1703 20 LPS2-triggered lps2-triggered JJ cord-015021-pol2qm74 1703 21 mediator mediator NN cord-015021-pol2qm74 1703 22 production production NN cord-015021-pol2qm74 1703 23 . . . cord-015021-pol2qm74 1704 1 Conclusion conclusion NN cord-015021-pol2qm74 1704 2 : : : cord-015021-pol2qm74 1704 3 Human human JJ cord-015021-pol2qm74 1704 4 monoeyte monoeyte JJ cord-015021-pol2qm74 1704 5 mediator mediator NN cord-015021-pol2qm74 1704 6 production production NN cord-015021-pol2qm74 1704 7 is be VBZ cord-015021-pol2qm74 1704 8 differentially differentially RB cord-015021-pol2qm74 1704 9 regulated regulate VBN cord-015021-pol2qm74 1704 10 by by IN cord-015021-pol2qm74 1704 11 preexposure preexposure NN cord-015021-pol2qm74 1704 12 to to IN cord-015021-pol2qm74 1704 13 LPS LPS NNP cord-015021-pol2qm74 1704 14 1 1 CD cord-015021-pol2qm74 1704 15 . . . cord-015021-pol2qm74 1705 1 Provocative provocative JJ cord-015021-pol2qm74 1705 2 in in IN cord-015021-pol2qm74 1705 3 vitro vitro FW cord-015021-pol2qm74 1705 4 testing testing NN cord-015021-pol2qm74 1705 5 of of IN cord-015021-pol2qm74 1705 6 monocytes monocyte NNS cord-015021-pol2qm74 1705 7 may may MD cord-015021-pol2qm74 1705 8 ultimately ultimately RB cord-015021-pol2qm74 1705 9 be be VB cord-015021-pol2qm74 1705 10 clinically clinically RB cord-015021-pol2qm74 1705 11 useful useful JJ cord-015021-pol2qm74 1705 12 to to TO cord-015021-pol2qm74 1705 13 identify identify VB cord-015021-pol2qm74 1705 14 prior prior RB cord-015021-pol2qm74 1705 15 in in IN cord-015021-pol2qm74 1705 16 vivo vivo NNP cord-015021-pol2qm74 1705 17 LPS LPS NNP cord-015021-pol2qm74 1705 18 exposure exposure NN cord-015021-pol2qm74 1705 19 or or CC cord-015021-pol2qm74 1705 20 MO MO NNP cord-015021-pol2qm74 1705 21 Macrophages macrophage NNS cord-015021-pol2qm74 1706 1 release release VB cord-015021-pol2qm74 1706 2 numerous numerous JJ cord-015021-pol2qm74 1706 3 secretory secretory JJ cord-015021-pol2qm74 1706 4 products product NNS cord-015021-pol2qm74 1706 5 involved involve VBN cord-015021-pol2qm74 1706 6 in in IN cord-015021-pol2qm74 1706 7 host host NN cord-015021-pol2qm74 1706 8 defense defense NN cord-015021-pol2qm74 1706 9 and and CC cord-015021-pol2qm74 1706 10 inflammation inflammation NN cord-015021-pol2qm74 1706 11 . . . cord-015021-pol2qm74 1707 1 Activated activate VBN cord-015021-pol2qm74 1707 2 macrophages macrophage NNS cord-015021-pol2qm74 1707 3 with with IN cord-015021-pol2qm74 1707 4 cytokines cytokine NNS cord-015021-pol2qm74 1707 5 produced produce VBN cord-015021-pol2qm74 1707 6 have have VBP cord-015021-pol2qm74 1707 7 been be VBN cord-015021-pol2qm74 1707 8 implicated implicate VBN cord-015021-pol2qm74 1707 9 in in IN cord-015021-pol2qm74 1707 10 tissue tissue NN cord-015021-pol2qm74 1707 11 damage damage NN cord-015021-pol2qm74 1707 12 in in IN cord-015021-pol2qm74 1707 13 sepsis sepsis NN cord-015021-pol2qm74 1707 14 and and CC cord-015021-pol2qm74 1707 15 multiple multiple JJ cord-015021-pol2qm74 1707 16 organ organ NN cord-015021-pol2qm74 1707 17 dysfunction dysfunction NN cord-015021-pol2qm74 1707 18 . . . cord-015021-pol2qm74 1708 1 Aimed aim VBN cord-015021-pol2qm74 1708 2 to to TO cord-015021-pol2qm74 1708 3 elucidate elucidate VB cord-015021-pol2qm74 1708 4 the the DT cord-015021-pol2qm74 1708 5 organ organ NN cord-015021-pol2qm74 1708 6 - - HYPH cord-015021-pol2qm74 1708 7 association association NN cord-015021-pol2qm74 1708 8 phenomena phenomena NN cord-015021-pol2qm74 1708 9 , , , cord-015021-pol2qm74 1708 10 this this DT cord-015021-pol2qm74 1708 11 study study NN cord-015021-pol2qm74 1708 12 is be VBZ cord-015021-pol2qm74 1708 13 to to TO cord-015021-pol2qm74 1708 14 compare compare VB cord-015021-pol2qm74 1708 15 peritoneal peritoneal NN cord-015021-pol2qm74 1708 16 macrophage(PM),alveolar macrophage(PM),alveolar NNP cord-015021-pol2qm74 1708 17 macrophage(AM macrophage(AM NNP cord-015021-pol2qm74 1708 18 ) ) -RRB- cord-015021-pol2qm74 1708 19 , , , cord-015021-pol2qm74 1708 20 and and CC cord-015021-pol2qm74 1708 21 Kupffer Kupffer NNP cord-015021-pol2qm74 1708 22 cells(KC cells(kc CD cord-015021-pol2qm74 1708 23 ) ) -RRB- cord-015021-pol2qm74 1709 1 during during IN cord-015021-pol2qm74 1709 2 sepsis sepsis NN cord-015021-pol2qm74 1709 3 in in IN cord-015021-pol2qm74 1709 4 terms term NNS cord-015021-pol2qm74 1709 5 of of IN cord-015021-pol2qm74 1709 6 cellular cellular JJ cord-015021-pol2qm74 1709 7 protein protein NN cord-015021-pol2qm74 1709 8 contents content NNS cord-015021-pol2qm74 1709 9 as as IN cord-015021-pol2qm74 1709 10 symbol symbol NN cord-015021-pol2qm74 1709 11 of of IN cord-015021-pol2qm74 1709 12 activation activation NN cord-015021-pol2qm74 1709 13 by by IN cord-015021-pol2qm74 1709 14 flow flow NN cord-015021-pol2qm74 1709 15 cytometry cytometry NN cord-015021-pol2qm74 1709 16 analysis analysis NN cord-015021-pol2qm74 1709 17 . . . cord-015021-pol2qm74 1710 1 Sepsis sepsis NN cord-015021-pol2qm74 1710 2 were be VBD cord-015021-pol2qm74 1710 3 produced produce VBN cord-015021-pol2qm74 1710 4 by by IN cord-015021-pol2qm74 1710 5 cecal cecal JJ cord-015021-pol2qm74 1710 6 ligatien ligatien NNP cord-015021-pol2qm74 1710 7 and and CC cord-015021-pol2qm74 1710 8 perforation perforation NN cord-015021-pol2qm74 1710 9 ( ( -LRB- cord-015021-pol2qm74 1710 10 CLP CLP NNP cord-015021-pol2qm74 1710 11 ) ) -RRB- cord-015021-pol2qm74 1710 12 in in IN cord-015021-pol2qm74 1710 13 Wistar Wistar NNP cord-015021-pol2qm74 1710 14 rats rat NNS cord-015021-pol2qm74 1710 15 weighing weigh VBG cord-015021-pol2qm74 1710 16 210 210 CD cord-015021-pol2qm74 1710 17 - - SYM cord-015021-pol2qm74 1710 18 290 290 CD cord-015021-pol2qm74 1710 19 g g NN cord-015021-pol2qm74 1710 20 . . . cord-015021-pol2qm74 1711 1 PM pm NN cord-015021-pol2qm74 1711 2 were be VBD cord-015021-pol2qm74 1711 3 obtained obtain VBN cord-015021-pol2qm74 1711 4 by by IN cord-015021-pol2qm74 1711 5 peritoneal peritoneal JJ cord-015021-pol2qm74 1711 6 lavage lavage NN cord-015021-pol2qm74 1711 7 , , , cord-015021-pol2qm74 1711 8 AM am NN cord-015021-pol2qm74 1711 9 by by IN cord-015021-pol2qm74 1711 10 bronchial bronchial JJ cord-015021-pol2qm74 1711 11 lavage lavage NN cord-015021-pol2qm74 1711 12 and and CC cord-015021-pol2qm74 1711 13 KC KC NNP cord-015021-pol2qm74 1711 14 by by IN cord-015021-pol2qm74 1711 15 incubating incubate VBG cord-015021-pol2qm74 1711 16 the the DT cord-015021-pol2qm74 1711 17 collegenase collegenase NNP cord-015021-pol2qm74 1711 18 digested digest VBN cord-015021-pol2qm74 1711 19 liver liver NN cord-015021-pol2qm74 1711 20 with with IN cord-015021-pol2qm74 1711 21 pronase pronase NNP cord-015021-pol2qm74 1711 22 - - HYPH cord-015021-pol2qm74 1711 23 E. E. NNP cord-015021-pol2qm74 1711 24 Leukocytes Leukocytes NNP cord-015021-pol2qm74 1711 25 have have VBP cord-015021-pol2qm74 1711 26 been be VBN cord-015021-pol2qm74 1711 27 implicated implicate VBN cord-015021-pol2qm74 1711 28 as as IN cord-015021-pol2qm74 1711 29 a a DT cord-015021-pol2qm74 1711 30 mediator mediator NN cord-015021-pol2qm74 1711 31 of of IN cord-015021-pol2qm74 1711 32 the the DT cord-015021-pol2qm74 1711 33 microvascular microvascular JJ cord-015021-pol2qm74 1711 34 dysfunction dysfunction NN cord-015021-pol2qm74 1711 35 associated associate VBN cord-015021-pol2qm74 1711 36 with with IN cord-015021-pol2qm74 1711 37 reperfasion reperfasion NN cord-015021-pol2qm74 1711 38 of of IN cord-015021-pol2qm74 1711 39 ischemic ischemic JJ cord-015021-pol2qm74 1711 40 tissues tissue NNS cord-015021-pol2qm74 1711 41 . . . cord-015021-pol2qm74 1712 1 A a DT cord-015021-pol2qm74 1712 2 role role NN cord-015021-pol2qm74 1712 3 for for IN cord-015021-pol2qm74 1712 4 Ieukocytes Ieukocytes NNPS cord-015021-pol2qm74 1712 5 is be VBZ cord-015021-pol2qm74 1712 6 largely largely RB cord-015021-pol2qm74 1712 7 based base VBN cord-015021-pol2qm74 1712 8 on on IN cord-015021-pol2qm74 1712 9 observations observation NNS cord-015021-pol2qm74 1712 10 that that IN cord-015021-pol2qm74 1712 11 rendering render VBG cord-015021-pol2qm74 1712 12 animals animal NNS cord-015021-pol2qm74 1712 13 anutropenic anutropenic JJ cord-015021-pol2qm74 1712 14 with with IN cord-015021-pol2qm74 1712 15 anti anti JJ cord-015021-pol2qm74 1712 16 - - JJ cord-015021-pol2qm74 1712 17 neutrophil neutrophil JJ cord-015021-pol2qm74 1712 18 serum serum NN cord-015021-pol2qm74 1712 19 or or CC cord-015021-pol2qm74 1712 20 preventing prevent VBG cord-015021-pol2qm74 1712 21 leukocyte leukocyte NN cord-015021-pol2qm74 1712 22 adhesion adhesion NN cord-015021-pol2qm74 1712 23 with with IN cord-015021-pol2qm74 1712 24 monoclonal monoclonal JJ cord-015021-pol2qm74 1712 25 antibodies antibody NNS cord-015021-pol2qm74 1712 26 attenuates attenuate VBZ cord-015021-pol2qm74 1712 27 the the DT cord-015021-pol2qm74 1712 28 increased increase VBN cord-015021-pol2qm74 1712 29 fluid fluid NN cord-015021-pol2qm74 1712 30 and and CC cord-015021-pol2qm74 1712 31 protein protein NN cord-015021-pol2qm74 1712 32 leakage leakage NN cord-015021-pol2qm74 1712 33 from from IN cord-015021-pol2qm74 1712 34 the the DT cord-015021-pol2qm74 1712 35 vaseulature vaseulature NN cord-015021-pol2qm74 1712 36 that that WDT cord-015021-pol2qm74 1712 37 is be VBZ cord-015021-pol2qm74 1712 38 normally normally RB cord-015021-pol2qm74 1712 39 observed observe VBN cord-015021-pol2qm74 1712 40 in in IN cord-015021-pol2qm74 1712 41 postischemic postischemic JJ cord-015021-pol2qm74 1712 42 tissues tissue NNS cord-015021-pol2qm74 1712 43 . . . cord-015021-pol2qm74 1713 1 We -PRON- PRP cord-015021-pol2qm74 1713 2 have have VBP cord-015021-pol2qm74 1713 3 recently recently RB cord-015021-pol2qm74 1713 4 undertaken undertake VBN cord-015021-pol2qm74 1713 5 studies study NNS cord-015021-pol2qm74 1713 6 designed design VBN cord-015021-pol2qm74 1713 7 to to TO cord-015021-pol2qm74 1713 8 determine determine VB cord-015021-pol2qm74 1713 9 the the DT cord-015021-pol2qm74 1713 10 relationship relationship NN cord-015021-pol2qm74 1713 11 between between IN cord-015021-pol2qm74 1713 12 leukocyte leukocyte NN cord-015021-pol2qm74 1713 13 - - HYPH cord-015021-pol2qm74 1713 14 endothelial endothelial JJ cord-015021-pol2qm74 1713 15 cell cell NN cord-015021-pol2qm74 1713 16 adhesion adhesion NN cord-015021-pol2qm74 1713 17 and and CC cord-015021-pol2qm74 1713 18 albumin albumin NN cord-015021-pol2qm74 1713 19 leakage leakage NN cord-015021-pol2qm74 1713 20 ia ia NNP cord-015021-pol2qm74 1713 21 rat rat NNP cord-015021-pol2qm74 1713 22 mesenterlc mesenterlc NNP cord-015021-pol2qm74 1713 23 venules venule NNS cord-015021-pol2qm74 1713 24 exposed expose VBN cord-015021-pol2qm74 1714 1 ~o ~o NFP cord-015021-pol2qm74 1714 2 ischemia ischemia NN cord-015021-pol2qm74 1714 3 - - HYPH cord-015021-pol2qm74 1714 4 reperfusion reperfusion NN cord-015021-pol2qm74 1714 5 ( ( -LRB- cord-015021-pol2qm74 1714 6 I i NN cord-015021-pol2qm74 1714 7 / / SYM cord-015021-pol2qm74 1714 8 R r NN cord-015021-pol2qm74 1714 9 ) ) -RRB- cord-015021-pol2qm74 1714 10 . . . cord-015021-pol2qm74 1715 1 Leukocyte Leukocyte NNP cord-015021-pol2qm74 1715 2 adherence adherence NN cord-015021-pol2qm74 1715 3 and and CC cord-015021-pol2qm74 1715 4 emigration emigration NN cord-015021-pol2qm74 1715 5 as as RB cord-015021-pol2qm74 1715 6 well well RB cord-015021-pol2qm74 1715 7 as as IN cord-015021-pol2qm74 1715 8 albumin albumin NN cord-015021-pol2qm74 1715 9 extravasafion extravasafion NN cord-015021-pol2qm74 1715 10 were be VBD cord-015021-pol2qm74 1715 11 monitored monitor VBN cord-015021-pol2qm74 1715 12 in in IN cord-015021-pol2qm74 1715 13 single single JJ cord-015021-pol2qm74 1715 14 postcapillary postcapillary JJ cord-015021-pol2qm74 1715 15 venules venule NNS cord-015021-pol2qm74 1715 16 using use VBG cord-015021-pol2qm74 1715 17 iatravital iatravital JJ cord-015021-pol2qm74 1715 18 fluorescence fluorescence NN cord-015021-pol2qm74 1715 19 microscopy microscopy NN cord-015021-pol2qm74 1715 20 , , , cord-015021-pol2qm74 1715 21 lschemia lschemia NNP cord-015021-pol2qm74 1715 22 was be VBD cord-015021-pol2qm74 1715 23 induced induce VBN cord-015021-pol2qm74 1715 24 by by IN cord-015021-pol2qm74 1715 25 complete complete JJ cord-015021-pol2qm74 1715 26 occ!usion occ!usion NN cord-015021-pol2qm74 1715 27 of of IN cord-015021-pol2qm74 1715 28 the the DT cord-015021-pol2qm74 1715 29 superior superior JJ cord-015021-pol2qm74 1715 30 mesenteric mesenteric JJ cord-015021-pol2qm74 1715 31 artery artery NN cord-015021-pol2qm74 1715 32 and and CC cord-015021-pol2qm74 1716 1 ~dl ~dl NN cord-015021-pol2qm74 1716 2 parameters parameter NNS cord-015021-pol2qm74 1716 3 were be VBD cord-015021-pol2qm74 1716 4 monitored monitor VBN cord-015021-pol2qm74 1716 5 at at IN cord-015021-pol2qm74 1716 6 various various JJ cord-015021-pol2qm74 1716 7 intervals interval NNS cord-015021-pol2qm74 1716 8 following follow VBG cord-015021-pol2qm74 1716 9 reperfusion reperfusion NN cord-015021-pol2qm74 1716 10 . . . cord-015021-pol2qm74 1717 1 The the DT cord-015021-pol2qm74 1717 2 magnitude magnitude NN cord-015021-pol2qm74 1717 3 of of IN cord-015021-pol2qm74 1717 4 the the DT cord-015021-pol2qm74 1717 5 leukocyte leukocyte NN cord-015021-pol2qm74 1717 6 adherence adherence NN cord-015021-pol2qm74 1717 7 and and CC cord-015021-pol2qm74 1717 8 emigration emigration NN cord-015021-pol2qm74 1717 9 , , , cord-015021-pol2qm74 1717 10 and and CC cord-015021-pol2qm74 1717 11 albumin albumin NN cord-015021-pol2qm74 1717 12 leakage leakage NN cord-015021-pol2qm74 1717 13 elicited elicit VBN cord-015021-pol2qm74 1717 14 by by IN cord-015021-pol2qm74 1717 15 I I NNP cord-015021-pol2qm74 1717 16 / / SYM cord-015021-pol2qm74 1717 17 R R NNP cord-015021-pol2qm74 1717 18 was be VBD cord-015021-pol2qm74 1717 19 positively positively RB cord-015021-pol2qm74 1717 20 con con JJ cord-015021-pol2qm74 1717 21 - - HYPH cord-015021-pol2qm74 1717 22 elated elated JJ cord-015021-pol2qm74 1717 23 with with IN cord-015021-pol2qm74 1717 24 the the DT cord-015021-pol2qm74 1717 25 duration duration NN cord-015021-pol2qm74 1717 26 of of IN cord-015021-pol2qm74 1717 27 ischemia ischemia NN cord-015021-pol2qm74 1717 28 . . . cord-015021-pol2qm74 1718 1 The the DT cord-015021-pol2qm74 1718 2 albumin albumin NN cord-015021-pol2qm74 1718 3 leakage leakage NN cord-015021-pol2qm74 1718 4 response response NN cord-015021-pol2qm74 1718 5 was be VBD cord-015021-pol2qm74 1718 6 also also RB cord-015021-pol2qm74 1718 7 highly highly RB cord-015021-pol2qm74 1718 8 correlated correlate VBN cord-015021-pol2qm74 1718 9 with with IN cord-015021-pol2qm74 1718 10 the the DT cord-015021-pol2qm74 1718 11 number number NN cord-015021-pol2qm74 1718 12 of of IN cord-015021-pol2qm74 1718 13 adherent adherent JJ cord-015021-pol2qm74 1718 14 and and CC cord-015021-pol2qm74 1718 15 emigrated emigrate VBD cord-015021-pol2qm74 1718 16 leukocytes leukocyte NNS cord-015021-pol2qm74 1718 17 . . . cord-015021-pol2qm74 1719 1 Monoclonal monoclonal JJ cord-015021-pol2qm74 1719 2 antibodies antibody NNS cord-015021-pol2qm74 1719 3 against against IN cord-015021-pol2qm74 1719 4 the the DT cord-015021-pol2qm74 1719 5 adhesion adhesion NN cord-015021-pol2qm74 1719 6 glycoproteins glycoprotein NNS cord-015021-pol2qm74 1719 7 CD18 CD18 NNP cord-015021-pol2qm74 1719 8 , , , cord-015021-pol2qm74 1719 9 CDllb CDllb NNP cord-015021-pol2qm74 1719 10 , , , cord-015021-pol2qm74 1719 11 ICAM-1 ICAM-1 NNP cord-015021-pol2qm74 1719 12 and and CC cord-015021-pol2qm74 1719 13 L L NNP cord-015021-pol2qm74 1719 14 - - HYPH cord-015021-pol2qm74 1719 15 selectin selectin NNP cord-015021-pol2qm74 1719 16 , , , cord-015021-pol2qm74 1719 17 but but CC cord-015021-pol2qm74 1719 18 not not RB cord-015021-pol2qm74 1719 19 P p NN cord-015021-pol2qm74 1719 20 - - , cord-015021-pol2qm74 1719 21 or or CC cord-015021-pol2qm74 1719 22 E e NN cord-015021-pol2qm74 1719 23 - - NN cord-015021-pol2qm74 1719 24 selecdn selecdn JJ cord-015021-pol2qm74 1719 25 , , , cord-015021-pol2qm74 1719 26 reduced reduce VBN cord-015021-pol2qm74 1719 27 I I NNP cord-015021-pol2qm74 1719 28 / / SYM cord-015021-pol2qm74 1719 29 R r NN cord-015021-pol2qm74 1719 30 - - HYPH cord-015021-pol2qm74 1719 31 induced induce VBN cord-015021-pol2qm74 1719 32 leukocyte leukocyte NN cord-015021-pol2qm74 1719 33 adherence adherence NN cord-015021-pol2qm74 1719 34 and and CC cord-015021-pol2qm74 1719 35 emigration emigration NN cord-015021-pol2qm74 1719 36 as as RB cord-015021-pol2qm74 1719 37 well well RB cord-015021-pol2qm74 1719 38 as as IN cord-015021-pol2qm74 1719 39 albumin albumin NN cord-015021-pol2qm74 1719 40 leakage leakage NN cord-015021-pol2qm74 1719 41 . . . cord-015021-pol2qm74 1720 1 PhaUoidln PhaUoidln NNP cord-015021-pol2qm74 1720 2 , , , cord-015021-pol2qm74 1720 3 an an DT cord-015021-pol2qm74 1720 4 F F NNP cord-015021-pol2qm74 1720 5 - - HYPH cord-015021-pol2qm74 1720 6 aetin aetin NNP cord-015021-pol2qm74 1720 7 stabilizer stabilizer NN cord-015021-pol2qm74 1720 8 , , , cord-015021-pol2qm74 1720 9 largely largely RB cord-015021-pol2qm74 1720 10 prevented prevent VBD cord-015021-pol2qm74 1720 11 the the DT cord-015021-pol2qm74 1720 12 emigration emigration NN cord-015021-pol2qm74 1720 13 ( ( -LRB- cord-015021-pol2qm74 1720 14 but but CC cord-015021-pol2qm74 1720 15 not not RB cord-015021-pol2qm74 1720 16 adherence adherence NN cord-015021-pol2qm74 1720 17 ) ) -RRB- cord-015021-pol2qm74 1720 18 of of IN cord-015021-pol2qm74 1720 19 leukocytes leukocyte NNS cord-015021-pol2qm74 1720 20 and and CC cord-015021-pol2qm74 1720 21 greatly greatly RB cord-015021-pol2qm74 1720 22 reduced reduce VBN cord-015021-pol2qm74 1720 23 , , , cord-015021-pol2qm74 1720 24 the the DT cord-015021-pol2qm74 1720 25 raicrovascular raicrovascular JJ cord-015021-pol2qm74 1720 26 protein protein NN cord-015021-pol2qm74 1720 27 leakage leakage NN cord-015021-pol2qm74 1720 28 . . . cord-015021-pol2qm74 1721 1 Plateletleukocyte Plateletleukocyte NNP cord-015021-pol2qm74 1721 2 aggregates aggregate NNS cord-015021-pol2qm74 1721 3 were be VBD cord-015021-pol2qm74 1721 4 formed form VBN cord-015021-pol2qm74 1721 5 in in IN cord-015021-pol2qm74 1721 6 postischemic postischemic NNP cord-015021-pol2qm74 1721 7 vemdes vemde NNS cord-015021-pol2qm74 1721 8 ; ; : cord-015021-pol2qm74 1721 9 the the DT cord-015021-pol2qm74 1721 10 number number NN cord-015021-pol2qm74 1721 11 of of IN cord-015021-pol2qm74 1721 12 aggregates aggregate NNS cord-015021-pol2qm74 1721 13 was be VBD cord-015021-pol2qm74 1721 14 reduced reduce VBN cord-015021-pol2qm74 1721 15 by by IN cord-015021-pol2qm74 1721 16 antibodies antibody NNS cord-015021-pol2qm74 1721 17 against against IN cord-015021-pol2qm74 1721 18 P p NN cord-015021-pol2qm74 1721 19 - - HYPH cord-015021-pol2qm74 1721 20 selecdh selecdh NNP cord-015021-pol2qm74 1721 21 , , , cord-015021-pol2qm74 1721 22 CDIlb CDIlb NNP cord-015021-pol2qm74 1721 23 , , , cord-015021-pol2qm74 1721 24 CD18 CD18 NNP cord-015021-pol2qm74 1721 25 , , , cord-015021-pol2qm74 1721 26 and and CC cord-015021-pol2qm74 1721 27 ICAM-1 icam-1 NN cord-015021-pol2qm74 1721 28 , , , cord-015021-pol2qm74 1721 29 but but CC cord-015021-pol2qm74 1721 30 not not RB cord-015021-pol2qm74 1721 31 E e NN cord-015021-pol2qm74 1721 32 - - NN cord-015021-pol2qm74 1721 33 selectin selectin JJ cord-015021-pol2qm74 1721 34 or or CC cord-015021-pol2qm74 1721 35 Lselectin Lselectin NNP cord-015021-pol2qm74 1721 36 . . . cord-015021-pol2qm74 1722 1 A a DT cord-015021-pol2qm74 1722 2 significant significant JJ cord-015021-pol2qm74 1722 3 fraction fraction NN cord-015021-pol2qm74 1722 4 of of IN cord-015021-pol2qm74 1722 5 the the DT cord-015021-pol2qm74 1722 6 mast mast NN cord-015021-pol2qm74 1722 7 ceils ceil NNS cord-015021-pol2qm74 1722 8 surrounding surround VBG cord-015021-pol2qm74 1722 9 the the DT cord-015021-pol2qm74 1722 10 posteapillary posteapillary JJ cord-015021-pol2qm74 1722 11 venules venule NNS cord-015021-pol2qm74 1722 12 degranulated degranulate VBN cord-015021-pol2qm74 1722 13 in in IN cord-015021-pol2qm74 1722 14 response response NN cord-015021-pol2qm74 1722 15 to to IN cord-015021-pol2qm74 1722 16 ischemia ischemia NN cord-015021-pol2qm74 1722 17 / / SYM cord-015021-pol2qm74 1722 18 repeffusion repeffusion NN cord-015021-pol2qm74 1722 19 , , , cord-015021-pol2qm74 1722 20 but but CC cord-015021-pol2qm74 1722 21 mast mast JJ cord-015021-pol2qm74 1722 22 cell cell NN cord-015021-pol2qm74 1722 23 stabilizers stabilizer NNS cord-015021-pol2qm74 1722 24 did do VBD cord-015021-pol2qm74 1722 25 not not RB cord-015021-pol2qm74 1722 26 afford afford VB cord-015021-pol2qm74 1722 27 protection protection NN cord-015021-pol2qm74 1722 28 against against IN cord-015021-pol2qm74 1722 29 the the DT cord-015021-pol2qm74 1722 30 albumin albumin NN cord-015021-pol2qm74 1722 31 leakage leakage NN cord-015021-pol2qm74 1722 32 elicited elicit VBN cord-015021-pol2qm74 1722 33 by by IN cord-015021-pol2qm74 1723 1 I I NNP cord-015021-pol2qm74 1723 2 / / SYM cord-015021-pol2qm74 1723 3 R. R. NNP cord-015021-pol2qm74 1723 4 These these DT cord-015021-pol2qm74 1723 5 results result NNS cord-015021-pol2qm74 1723 6 indicate indicate VBP cord-015021-pol2qm74 1723 7 that that IN cord-015021-pol2qm74 1723 8 reperfusloninduced reperfusloninduce VBN cord-015021-pol2qm74 1723 9 albumin albumin NN cord-015021-pol2qm74 1723 10 leakage leakage NN cord-015021-pol2qm74 1723 11 is be VBZ cord-015021-pol2qm74 1723 12 tightly tightly RB cord-015021-pol2qm74 1723 13 coupled couple VBN cord-015021-pol2qm74 1723 14 to to IN cord-015021-pol2qm74 1723 15 the the DT cord-015021-pol2qm74 1723 16 adherence adherence NN cord-015021-pol2qm74 1723 17 and and CC cord-015021-pol2qm74 1723 18 emigration emigration NN cord-015021-pol2qm74 1723 19 of of IN cord-015021-pol2qm74 1723 20 leukocytes leukocyte NNS cord-015021-pol2qm74 1723 21 in in IN cord-015021-pol2qm74 1723 22 posteapillary posteapillary NNP cord-015021-pol2qm74 1723 23 venules venule NNS cord-015021-pol2qm74 1723 24 . . . cord-015021-pol2qm74 1724 1 This this DT cord-015021-pol2qm74 1724 2 adhesiomdependent adhesiomdependent NN cord-015021-pol2qm74 1724 3 injury injury NN cord-015021-pol2qm74 1724 4 response response NN cord-015021-pol2qm74 1724 5 is be VBZ cord-015021-pol2qm74 1724 6 primarily primarily RB cord-015021-pol2qm74 1724 7 mediated mediate VBN cord-015021-pol2qm74 1724 8 by by IN cord-015021-pol2qm74 1724 9 CDllb CDllb NNP cord-015021-pol2qm74 1724 10 / / SYM cord-015021-pol2qm74 1724 11 CDI8 CDI8 NNP cord-015021-pol2qm74 1724 12 on on IN cord-015021-pol2qm74 1724 13 activated activate VBN cord-015021-pol2qm74 1724 14 neutrophils neutrophil NNS cord-015021-pol2qm74 1724 15 and and CC cord-015021-pol2qm74 1724 16 ICAM-1 ICAM-1 NNP cord-015021-pol2qm74 1724 17 on on IN cord-015021-pol2qm74 1724 18 venular venular JJ cord-015021-pol2qm74 1724 19 endothellum endothellum NN cord-015021-pol2qm74 1724 20 , , , cord-015021-pol2qm74 1724 21 and and CC cord-015021-pol2qm74 1724 22 appears appear VBZ cord-015021-pol2qm74 1724 23 to to TO cord-015021-pol2qm74 1724 24 require require VB cord-015021-pol2qm74 1724 25 L L NNP cord-015021-pol2qm74 1724 26 - - HYPH cord-015021-pol2qm74 1724 27 selecda selecda NNP cord-015021-pol2qm74 1724 28 dependent dependent JJ cord-015021-pol2qm74 1724 29 leukocyte leukocyte NN cord-015021-pol2qm74 1724 30 rolling rolling NN cord-015021-pol2qm74 1724 31 . . . cord-015021-pol2qm74 1725 1 Mast mast JJ cord-015021-pol2qm74 1725 2 cell cell NN cord-015021-pol2qm74 1725 3 degranulation degranulation NN cord-015021-pol2qm74 1725 4 does do VBZ cord-015021-pol2qm74 1725 5 not not RB cord-015021-pol2qm74 1725 6 appear appear VB cord-015021-pol2qm74 1725 7 to to TO cord-015021-pol2qm74 1725 8 conwibate conwibate VB cord-015021-pol2qm74 1725 9 to to IN cord-015021-pol2qm74 1725 10 the the DT cord-015021-pol2qm74 1725 11 vascular vascular JJ cord-015021-pol2qm74 1725 12 pathology pathology NN cord-015021-pol2qm74 1725 13 associated associate VBN cord-015021-pol2qm74 1725 14 with with IN cord-015021-pol2qm74 1725 15 I I NNP cord-015021-pol2qm74 1725 16 / / SYM cord-015021-pol2qm74 1725 17 R. R. NNP cord-015021-pol2qm74 1725 18 M.D. M.D. NNP cord-015021-pol2qm74 1725 19 Rod Rod NNP cord-015021-pol2qm74 1725 20 = = SYM cord-015021-pol2qm74 1725 21 iek iek NNP cord-015021-pol2qm74 1725 22 , , , cord-015021-pol2qm74 1725 23 Boston Boston NNP cord-015021-pol2qm74 1725 24 , , , cord-015021-pol2qm74 1725 25 MA MA NNP cord-015021-pol2qm74 1725 26 , , , cord-015021-pol2qm74 1725 27 USA USA NNP cord-015021-pol2qm74 1726 1 The the DT cord-015021-pol2qm74 1726 2 polymorphonuclear polymorphonuclear JJ cord-015021-pol2qm74 1726 3 neutrophil neutrophil NN cord-015021-pol2qm74 1726 4 ( ( -LRB- cord-015021-pol2qm74 1726 5 PMN PMN NNP cord-015021-pol2qm74 1726 6 ) ) -RRB- cord-015021-pol2qm74 1726 7 has have VBZ cord-015021-pol2qm74 1726 8 long long RB cord-015021-pol2qm74 1726 9 been be VBN cord-015021-pol2qm74 1726 10 known know VBN cord-015021-pol2qm74 1726 11 to to IN cord-015021-pol2qm74 1726 12 pa pa NNP cord-015021-pol2qm74 1727 1 ~tlcipats ~tlcipats XX cord-015021-pol2qm74 1727 2 in in IN cord-015021-pol2qm74 1727 3 the the DT cord-015021-pol2qm74 1727 4 inflammatory inflammatory JJ cord-015021-pol2qm74 1727 5 reBpons~ reBpons~ NNP cord-015021-pol2qm74 1727 6 as as IN cord-015021-pol2qm74 1727 7 a a DT cord-015021-pol2qm74 1727 8 phagocyte phagocyte NN cord-015021-pol2qm74 1727 9 and and CC cord-015021-pol2qm74 1727 10 killer killer NN cord-015021-pol2qm74 1727 11 Of of IN cord-015021-pol2qm74 1727 12 invading invade VBG cord-015021-pol2qm74 1727 13 organisms organism NNS cord-015021-pol2qm74 1727 14 , , , cord-015021-pol2qm74 1727 15 but but CC cord-015021-pol2qm74 1727 16 little little JJ cord-015021-pol2qm74 1727 17 attention attention NN cord-015021-pol2qm74 1727 18 has have VBZ cord-015021-pol2qm74 1727 19 been be VBN cord-015021-pol2qm74 1727 20 given give VBN cord-015021-pol2qm74 1727 21 to to IN cord-015021-pol2qm74 1727 22 its -PRON- PRP$ cord-015021-pol2qm74 1727 23 potential potential NN cord-015021-pol2qm74 1727 24 as as IN cord-015021-pol2qm74 1727 25 a a DT cord-015021-pol2qm74 1727 26 participant participant NN cord-015021-pol2qm74 1727 27 in in IN cord-015021-pol2qm74 1727 28 the the DT cord-015021-pol2qm74 1727 29 in in IN cord-015021-pol2qm74 1727 30 ~ ~ CD cord-015021-pol2qm74 1727 31 une une FW cord-015021-pol2qm74 1727 32 interaction interaction NN cord-015021-pol2qm74 1727 33 of of IN cord-015021-pol2qm74 1727 34 lymphocytes lymphocyte NNS cord-015021-pol2qm74 1727 35 and and CC cord-015021-pol2qm74 1727 36 macrophages macrophage NNS cord-015021-pol2qm74 1727 37 . . . cord-015021-pol2qm74 1728 1 We -PRON- PRP cord-015021-pol2qm74 1728 2 and and CC cord-015021-pol2qm74 1728 3 others other NNS cord-015021-pol2qm74 1728 4 have have VBP cord-015021-pol2qm74 1728 5 shown show VBN cord-015021-pol2qm74 1728 6 that that IN cord-015021-pol2qm74 1728 7 the the DT cord-015021-pol2qm74 1728 8 PMN PMN NNP cord-015021-pol2qm74 1728 9 may may MD cord-015021-pol2qm74 1728 10 have have VB cord-015021-pol2qm74 1728 11 i i PRP cord-015021-pol2qm74 1728 12 ~ ~ CD cord-015021-pol2qm74 1728 13 m~/nomcdulatory m~/nomcdulatory CD cord-015021-pol2qm74 1728 14 effects effect NNS cord-015021-pol2qm74 1728 15 both both DT cord-015021-pol2qm74 1728 16 in in IN cord-015021-pol2qm74 1728 17 vitro vitro FW cord-015021-pol2qm74 1728 18 and and CC cord-015021-pol2qm74 1728 19 in in IN cord-015021-pol2qm74 1728 20 vlvo vlvo NNP cord-015021-pol2qm74 1728 21 . . . cord-015021-pol2qm74 1729 1 More more RBR cord-015021-pol2qm74 1729 2 recently recently RB cord-015021-pol2qm74 1729 3 it -PRON- PRP cord-015021-pol2qm74 1729 4 has have VBZ cord-015021-pol2qm74 1729 5 been be VBN cord-015021-pol2qm74 1729 6 proven prove VBN cord-015021-pol2qm74 1729 7 that that IN cord-015021-pol2qm74 1729 8 the the DT cord-015021-pol2qm74 1729 9 PMN PMN NNP cord-015021-pol2qm74 1729 10 can can MD cord-015021-pol2qm74 1729 11 make make VB cord-015021-pol2qm74 1729 12 mRNA mrna NN cord-015021-pol2qm74 1729 13 for for IN cord-015021-pol2qm74 1729 14 and and CC cord-015021-pol2qm74 1729 15 secrete secrete VB cord-015021-pol2qm74 1729 16 the the DT cord-015021-pol2qm74 1729 17 proinflammatory proinflammatory JJ cord-015021-pol2qm74 1729 18 oytokines oytokine NNS cord-015021-pol2qm74 1729 19 ILla ILla NNP cord-015021-pol2qm74 1729 20 , , , cord-015021-pol2qm74 1729 21 IL IL NNP cord-015021-pol2qm74 1729 22 - - HYPH cord-015021-pol2qm74 1729 23 IB IB NNP cord-015021-pol2qm74 1729 24 , , , cord-015021-pol2qm74 1729 25 TNFS TNFS NNP cord-015021-pol2qm74 1729 26 , , , cord-015021-pol2qm74 1729 27 IL-6 IL-6 NNP cord-015021-pol2qm74 1729 28 and and CC cord-015021-pol2qm74 1729 29 IL-8 IL-8 NNP cord-015021-pol2qm74 1729 30 as as IN cord-015021-pol2qm74 1729 31 does do VBZ cord-015021-pol2qm74 1729 32 the the DT cord-015021-pol2qm74 1729 33 other other JJ cord-015021-pol2qm74 1729 34 major major JJ cord-015021-pol2qm74 1729 35 circulating circulate VBG cord-015021-pol2qm74 1729 36 phagocyte phagocyte NNP cord-015021-pol2qm74 1729 37 , , , cord-015021-pol2qm74 1729 38 the the DT cord-015021-pol2qm74 1729 39 monocyte monocyte NNP cord-015021-pol2qm74 1729 40 / / SYM cord-015021-pol2qm74 1729 41 macrophags macrophags NNP cord-015021-pol2qm74 1729 42 . . . cord-015021-pol2qm74 1730 1 Furthermore furthermore RB cord-015021-pol2qm74 1730 2 it -PRON- PRP cord-015021-pol2qm74 1730 3 has have VBZ cord-015021-pol2qm74 1730 4 been be VBN cord-015021-pol2qm74 1730 5 shown show VBN cord-015021-pol2qm74 1730 6 to to TO cord-015021-pol2qm74 1730 7 make make VB cord-015021-pol2qm74 1730 8 the the DT cord-015021-pol2qm74 1730 9 potentially potentially RB cord-015021-pol2qm74 1730 10 autoregulatory autoregulatory NNP cord-015021-pol2qm74 1730 11 oytokines oytokines NNP cord-015021-pol2qm74 1730 12 GCSF GCSF NNP cord-015021-pol2qm74 1730 13 and and CC cord-015021-pol2qm74 1730 14 GMCSF GMCSF NNP cord-015021-pol2qm74 1730 15 . . . cord-015021-pol2qm74 1731 1 These these DT cord-015021-pol2qm74 1731 2 functional functional JJ cord-015021-pol2qm74 1731 3 capabilities capability NNS cord-015021-pol2qm74 1731 4 suggest suggest VBP cord-015021-pol2qm74 1731 5 that that IN cord-015021-pol2qm74 1731 6 the the DT cord-015021-pol2qm74 1731 7 PMN PMN NNP cord-015021-pol2qm74 1731 8 is be VBZ cord-015021-pol2qm74 1731 9 not not RB cord-015021-pol2qm74 1731 10 an an DT cord-015021-pol2qm74 1731 11 Wend Wend NNP cord-015021-pol2qm74 1731 12 cell cell NN cord-015021-pol2qm74 1731 13 ~ ~ NFP cord-015021-pol2qm74 1731 14 , , , cord-015021-pol2qm74 1731 15 but but CC cord-015021-pol2qm74 1731 16 one one NN cord-015021-pol2qm74 1731 17 which which WDT cord-015021-pol2qm74 1731 18 has have VBZ cord-015021-pol2qm74 1731 19 a a DT cord-015021-pol2qm74 1731 20 potential potential JJ cord-015021-pol2qm74 1731 21 role role NN cord-015021-pol2qm74 1731 22 in in IN cord-015021-pol2qm74 1731 23 regulation regulation NN cord-015021-pol2qm74 1731 24 cf cf NN cord-015021-pol2qm74 1732 1 ~he ~he NNP cord-015021-pol2qm74 1732 2 immune immune JJ cord-015021-pol2qm74 1732 3 response response NN cord-015021-pol2qm74 1732 4 and and CC cord-015021-pol2qm74 1732 5 that that IN cord-015021-pol2qm74 1732 6 this this DT cord-015021-pol2qm74 1732 7 potential potential NN cord-015021-pol2qm74 1732 8 ~cle ~cle NNP cord-015021-pol2qm74 1732 9 should should MD cord-015021-pol2qm74 1732 10 no no RB cord-015021-pol2qm74 1732 11 longer longer RB cord-015021-pol2qm74 1732 12 be be VB cord-015021-pol2qm74 1732 13 ignored ignore VBN cord-015021-pol2qm74 1732 14 when when WRB cord-015021-pol2qm74 1732 15 considering consider VBG cord-015021-pol2qm74 1732 16 the the DT cord-015021-pol2qm74 1732 17 immune immune JJ cord-015021-pol2qm74 1732 18 abnormalities abnormality NNS cord-015021-pol2qm74 1732 19 existing exist VBG cord-015021-pol2qm74 1732 20 in in IN cord-015021-pol2qm74 1732 21 patients patient NNS cord-015021-pol2qm74 1732 22 following follow VBG cord-015021-pol2qm74 1732 23 maJo~ majo~ CD cord-015021-pol2qm74 1732 24 injury injury NN cord-015021-pol2qm74 1732 25 or or CC cord-015021-pol2qm74 1732 26 surgery surgery NN cord-015021-pol2qm74 1732 27 . . . cord-015021-pol2qm74 1733 1 We -PRON- PRP cord-015021-pol2qm74 1733 2 have have VBP cord-015021-pol2qm74 1733 3 investigated investigate VBN cord-015021-pol2qm74 1733 4 the the DT cord-015021-pol2qm74 1733 5 proinflaznmatory proinflaznmatory JJ cord-015021-pol2qm74 1733 6 oytokine oytokine JJ cord-015021-pol2qm74 1733 7 secretion secretion NN cord-015021-pol2qm74 1733 8 patter~ patter~ VBN cord-015021-pol2qm74 1733 9 by by IN cord-015021-pol2qm74 1733 10 PMN PMN NNP cord-015021-pol2qm74 1733 11 in in IN cord-015021-pol2qm74 1733 12 patients patient NNS cord-015021-pol2qm74 1733 13 following follow VBG cord-015021-pol2qm74 1733 14 major major JJ cord-015021-pol2qm74 1733 15 ~hermal ~hermal NNP cord-015021-pol2qm74 1733 16 or or CC cord-015021-pol2qm74 1733 17 tra tra NNP cord-015021-pol2qm74 1733 18 ~ ~ NNP cord-015021-pol2qm74 1733 19 matic matic NNP cord-015021-pol2qm74 1733 20 injury injury NN cord-015021-pol2qm74 1733 21 and and CC cord-015021-pol2qm74 1733 22 in in IN cord-015021-pol2qm74 1733 23 volunteers volunteer NNS cord-015021-pol2qm74 1733 24 fellowinq fellowinq NN cord-015021-pol2qm74 1733 25 endotoxemia endotoxemia NN cord-015021-pol2qm74 1733 26 . . . cord-015021-pol2qm74 1733 27 ? ? . cord-015021-pol2qm74 1734 1 ollowing ollowe VBG cord-015021-pol2qm74 1734 2 major major JJ cord-015021-pol2qm74 1734 3 injury injury NN cord-015021-pol2qm74 1734 4 there there EX cord-015021-pol2qm74 1734 5 is be VBZ cord-015021-pol2qm74 1734 6 variable variable JJ cord-015021-pol2qm74 1734 7 PMN PMN NNP cord-015021-pol2qm74 1734 8 secretion secretion NN cord-015021-pol2qm74 1734 9 of of IN cord-015021-pol2qm74 1734 10 these these DT cord-015021-pol2qm74 1734 11 cytokines cytokine NNS cord-015021-pol2qm74 1734 12 when when WRB cord-015021-pol2qm74 1734 13 stimulated stimulate VBN cord-015021-pol2qm74 1734 14 in in IN cord-015021-pol2qm74 1734 15 vlero vlero NNP cord-015021-pol2qm74 1734 16 . . . cord-015021-pol2qm74 1735 1 Following follow VBG cord-015021-pol2qm74 1735 2 endotoxemia endotoxemia NN cord-015021-pol2qm74 1735 3 in in IN cord-015021-pol2qm74 1735 4 a a DT cord-015021-pol2qm74 1735 5 group group NN cord-015021-pol2qm74 1735 6 of of IN cord-015021-pol2qm74 1735 7 human human JJ cord-015021-pol2qm74 1735 8 volunteers volunteer NNS cord-015021-pol2qm74 1735 9 PMN PMN NNP cord-015021-pol2qm74 1735 10 showed show VBD cord-015021-pol2qm74 1735 11 a a DT cord-015021-pol2qm74 1735 12 hypo hypo NN cord-015021-pol2qm74 1736 1 = = SYM cord-015021-pol2qm74 1736 2 esponsivenesa esponsivenesa VBN cord-015021-pol2qm74 1736 3 to to IN cord-015021-pol2qm74 1736 4 LPS LPS NNP cord-015021-pol2qm74 1736 5 4 4 CD cord-015021-pol2qm74 1736 6 hrs hrs NN cord-015021-pol2qm74 1736 7 following follow VBG cord-015021-pol2qm74 1736 8 endotoxin endotoxin NN cord-015021-pol2qm74 1736 9 infusion infusion NN cord-015021-pol2qm74 1736 10 followed follow VBD cord-015021-pol2qm74 1736 11 at at IN cord-015021-pol2qm74 1736 12 24 24 CD cord-015021-pol2qm74 1736 13 hre hre NNP cord-015021-pol2qm74 1736 14 by by IN cord-015021-pol2qm74 1736 15 an an DT cord-015021-pol2qm74 1736 16 overshoot overshoot NN cord-015021-pol2qm74 1736 17 . . . cord-015021-pol2qm74 1737 1 Pretreatment pretreatment NN cord-015021-pol2qm74 1737 2 with with IN cord-015021-pol2qm74 1737 3 steroids steroid NNS cord-015021-pol2qm74 1737 4 modulated modulate VBN cord-015021-pol2qm74 1737 5 this this DT cord-015021-pol2qm74 1737 6 overshoot overshoot NN cord-015021-pol2qm74 1737 7 phenomenon phenomenon NN cord-015021-pol2qm74 1737 8 , , , cord-015021-pol2qm74 1737 9 suggesting suggest VBG cord-015021-pol2qm74 1737 10 that that IN cord-015021-pol2qm74 1737 11 receptors receptor NNS cord-015021-pol2qm74 1737 12 for for IN cord-015021-pol2qm74 1737 13 steroids steroid NNS cord-015021-pol2qm74 1737 14 are be VBP cord-015021-pol2qm74 1737 15 involved involve VBN cord-015021-pol2qm74 1737 16 in in IN cord-015021-pol2qm74 1737 17 the the DT cord-015021-pol2qm74 1737 18 regulation regulation NN cord-015021-pol2qm74 1737 19 of of IN cord-015021-pol2qm74 1737 20 cytokin cytokin NNP cord-015021-pol2qm74 1738 1 ® ® NNP cord-015021-pol2qm74 1738 2 secretlon secretlon NNP cord-015021-pol2qm74 1738 3 by by IN cord-015021-pol2qm74 1738 4 FMN FMN NNP cord-015021-pol2qm74 1738 5 . . . cord-015021-pol2qm74 1739 1 These these DT cord-015021-pol2qm74 1739 2 results result NNS cord-015021-pol2qm74 1739 3 sugges~ sugges~ JJ cord-015021-pol2qm74 1739 4 that that IN cord-015021-pol2qm74 1739 5 the the DT cord-015021-pol2qm74 1739 6 PMN PMN NNP cord-015021-pol2qm74 1739 7 , , , cord-015021-pol2qm74 1739 8 the the DT cord-015021-pol2qm74 1739 9 most most RBS cord-015021-pol2qm74 1739 10 numerous numerous JJ cord-015021-pol2qm74 1739 11 cell cell NN cord-015021-pol2qm74 1739 12 in in IN cord-015021-pol2qm74 1739 13 the the DT cord-015021-pol2qm74 1739 14 circulation circulation NN cord-015021-pol2qm74 1739 15 and and CC cord-015021-pol2qm74 1739 16 the the DT cord-015021-pol2qm74 1739 17 first first JJ cord-015021-pol2qm74 1739 18 to to TO cord-015021-pol2qm74 1739 19 respond respond VB cord-015021-pol2qm74 1739 20 to to IN cord-015021-pol2qm74 1739 21 an an DT cord-015021-pol2qm74 1739 22 ins in NNS cord-015021-pol2qm74 1739 23 ~ ~ NFP cord-015021-pol2qm74 1739 24 l~ l~ XX cord-015021-pol2qm74 1739 25 may may MD cord-015021-pol2qm74 1739 26 be be VB cord-015021-pol2qm74 1739 27 a a DT cord-015021-pol2qm74 1739 28 so so RB cord-015021-pol2qm74 1740 1 ~rce ~rce NNP cord-015021-pol2qm74 1740 2 of of IN cord-015021-pol2qm74 1740 3 the the DT cord-015021-pol2qm74 1740 4 prolnflammatory prolnflammatory NNP cord-015021-pol2qm74 1740 5 cytokine cytokine NN cord-015021-pol2qm74 1740 6 cascade cascade NN cord-015021-pol2qm74 1740 7 following follow VBG cord-015021-pol2qm74 1740 8 injury injury NN cord-015021-pol2qm74 1740 9 that that WDT cord-015021-pol2qm74 1740 10 has have VBZ cord-015021-pol2qm74 1740 11 been be VBN cord-015021-pol2qm74 1740 12 recognized recognize VBN cord-015021-pol2qm74 1740 13 as as RB cord-015021-pol2qm74 1740 14 significant significant JJ cord-015021-pol2qm74 1740 15 in in IN cord-015021-pol2qm74 1740 16 the the DT cord-015021-pol2qm74 1740 17 process process NN cord-015021-pol2qm74 1740 18 which which WDT cord-015021-pol2qm74 1740 19 often often RB cord-015021-pol2qm74 1740 20 leads lead VBZ cord-015021-pol2qm74 1740 21 to to IN cord-015021-pol2qm74 1740 22 multiple multiple JJ cord-015021-pol2qm74 1740 23 o;gan o;gan NNP cord-015021-pol2qm74 1740 24 failure failure NN cord-015021-pol2qm74 1740 25 , , , cord-015021-pol2qm74 1740 26 The the DT cord-015021-pol2qm74 1740 27 immunosuppresslon immunosuppresslon NN cord-015021-pol2qm74 1740 28 which which WDT cord-015021-pol2qm74 1740 29 occurs occur VBZ cord-015021-pol2qm74 1740 30 following follow VBG cord-015021-pol2qm74 1740 31 major major JJ cord-015021-pol2qm74 1740 32 thermal thermal JJ cord-015021-pol2qm74 1740 33 Injury injury NN cord-015021-pol2qm74 1740 34 may may MD cord-015021-pol2qm74 1740 35 predispose predispose VB cord-015021-pol2qm74 1740 36 these these DT cord-015021-pol2qm74 1740 37 individuals individual NNS cord-015021-pol2qm74 1740 38 to to IN cord-015021-pol2qm74 1740 39 infection infection NN cord-015021-pol2qm74 1740 40 and and CC cord-015021-pol2qm74 1740 41 sepsis sepsis NN cord-015021-pol2qm74 1740 42 , , , cord-015021-pol2qm74 1740 43 which which WDT cord-015021-pol2qm74 1740 44 remain remain VBP cord-015021-pol2qm74 1740 45 a a DT cord-015021-pol2qm74 1740 46 significant significant JJ cord-015021-pol2qm74 1740 47 cause cause NN cord-015021-pol2qm74 1740 48 of of IN cord-015021-pol2qm74 1740 49 morbidity morbidity NN cord-015021-pol2qm74 1740 50 and and CC cord-015021-pol2qm74 1740 51 mortality mortality NN cord-015021-pol2qm74 1740 52 . . . cord-015021-pol2qm74 1741 1 Included include VBN cord-015021-pol2qm74 1741 2 among among IN cord-015021-pol2qm74 1741 3 the the DT cord-015021-pol2qm74 1741 4 many many JJ cord-015021-pol2qm74 1741 5 Immune immune JJ cord-015021-pol2qm74 1741 6 aheratlons aheratlon NNS cord-015021-pol2qm74 1741 7 are be VBP cord-015021-pol2qm74 1741 8 the the DT cord-015021-pol2qm74 1741 9 p2 p2 NNP cord-015021-pol2qm74 1741 10 Integrln Integrln NNP cord-015021-pol2qm74 1741 11 ( ( -LRB- cord-015021-pol2qm74 1741 12 CDlla CDlla NNP cord-015021-pol2qm74 1741 13 , , , cord-015021-pol2qm74 1741 14 b b NN cord-015021-pol2qm74 1741 15 , , , cord-015021-pol2qm74 1741 16 c c NNP cord-015021-pol2qm74 1741 17 / / SYM cord-015021-pol2qm74 1741 18 CD18 CD18 NNP cord-015021-pol2qm74 1741 19 ) ) -RRB- cord-015021-pol2qm74 1741 20 dependent dependent JJ cord-015021-pol2qm74 1741 21 activities activity NNS cord-015021-pol2qm74 1741 22 of of IN cord-015021-pol2qm74 1741 23 adhesion adhesion NN cord-015021-pol2qm74 1741 24 , , , cord-015021-pol2qm74 1741 25 chemotaxls chemotaxls NNP cord-015021-pol2qm74 1741 26 , , , cord-015021-pol2qm74 1741 27 diapodesls diapodesls NN cord-015021-pol2qm74 1741 28 , , , cord-015021-pol2qm74 1741 29 and and CC cord-015021-pol2qm74 1741 30 phagocytosls phagocytosl NNS cord-015021-pol2qm74 1741 31 . . . cord-015021-pol2qm74 1742 1 Our -PRON- PRP$ cord-015021-pol2qm74 1742 2 Investigations investigation NNS cord-015021-pol2qm74 1742 3 indicate indicate VBP cord-015021-pol2qm74 1742 4 that that IN cord-015021-pol2qm74 1742 5 , , , cord-015021-pol2qm74 1742 6 following follow VBG cord-015021-pol2qm74 1742 7 major major JJ cord-015021-pol2qm74 1742 8 thermal thermal JJ cord-015021-pol2qm74 1742 9 injuries injury NNS cord-015021-pol2qm74 1742 10 , , , cord-015021-pol2qm74 1742 11 the the DT cord-015021-pol2qm74 1742 12 expression expression NN cord-015021-pol2qm74 1742 13 of of IN cord-015021-pol2qm74 1742 14 the the DT cord-015021-pol2qm74 1742 15 [ [ -LRB- cord-015021-pol2qm74 1742 16 ~2 ~2 NNP cord-015021-pol2qm74 1742 17 Integrlns Integrlns NNP cord-015021-pol2qm74 1742 18 , , , cord-015021-pol2qm74 1742 19 but but CC cord-015021-pol2qm74 1742 20 not not RB cord-015021-pol2qm74 1742 21 CD14 CD14 NNP cord-015021-pol2qm74 1742 22 , , , cord-015021-pol2qm74 1742 23 is be VBZ cord-015021-pol2qm74 1742 24 significantly significantly RB cord-015021-pol2qm74 1742 25 decreased decrease VBN cord-015021-pol2qm74 1742 26 on on IN cord-015021-pol2qm74 1742 27 neutrophlls neutrophll NNS cord-015021-pol2qm74 1742 28 ( ( -LRB- cord-015021-pol2qm74 1742 29 PMNs PMNs NNP cord-015021-pol2qm74 1742 30 ) ) -RRB- cord-015021-pol2qm74 1742 31 . . . cord-015021-pol2qm74 1743 1 It -PRON- PRP cord-015021-pol2qm74 1743 2 remains remain VBZ cord-015021-pol2qm74 1743 3 unclear unclear JJ cord-015021-pol2qm74 1743 4 if if IN cord-015021-pol2qm74 1743 5 PMNs pmn NNS cord-015021-pol2qm74 1743 6 from from IN cord-015021-pol2qm74 1743 7 thermally thermally RB cord-015021-pol2qm74 1743 8 Injured injure VBN cord-015021-pol2qm74 1743 9 patients patient NNS cord-015021-pol2qm74 1743 10 respond respond VBP cord-015021-pol2qm74 1743 11 normally normally RB cord-015021-pol2qm74 1743 12 to to IN cord-015021-pol2qm74 1743 13 LPS LPS NNP cord-015021-pol2qm74 1743 14 , , , cord-015021-pol2qm74 1743 15 The the DT cord-015021-pol2qm74 1743 16 effects effect NNS cord-015021-pol2qm74 1743 17 of of IN cord-015021-pol2qm74 1743 18 treatment treatment NN cord-015021-pol2qm74 1743 19 in in IN cord-015021-pol2qm74 1743 20 vitro vitro FW cord-015021-pol2qm74 1743 21 with with IN cord-015021-pol2qm74 1743 22 LPS LPS NNP cord-015021-pol2qm74 1743 23 and and CC cord-015021-pol2qm74 1743 24 f f NNP cord-015021-pol2qm74 1743 25 - - HYPH cord-015021-pol2qm74 1743 26 met meet VBN cord-015021-pol2qm74 1743 27 - - HYPH cord-015021-pol2qm74 1743 28 leu leu NN cord-015021-pol2qm74 1743 29 - - HYPH cord-015021-pol2qm74 1743 30 phe phe NNP cord-015021-pol2qm74 1743 31 ( ( -LRB- cord-015021-pol2qm74 1743 32 fMLP fMLP NNP cord-015021-pol2qm74 1743 33 ) ) -RRB- cord-015021-pol2qm74 1743 34 on on IN cord-015021-pol2qm74 1743 35 the the DT cord-015021-pol2qm74 1743 36 expression expression NN cord-015021-pol2qm74 1743 37 of of IN cord-015021-pol2qm74 1743 38 CDtlb CDtlb NNP cord-015021-pol2qm74 1743 39 was be VBD cord-015021-pol2qm74 1743 40 examlned examlne VBN cord-015021-pol2qm74 1743 41 on on IN cord-015021-pol2qm74 1743 42 PMNs pmn NNS cord-015021-pol2qm74 1743 43 from from IN cord-015021-pol2qm74 1743 44 the the DT cord-015021-pol2qm74 1743 45 peripheral peripheral JJ cord-015021-pol2qm74 1743 46 blood blood NN cord-015021-pol2qm74 1743 47 of of IN cord-015021-pol2qm74 1743 48 healthy healthy JJ cord-015021-pol2qm74 1743 49 volunteers volunteer NNS cord-015021-pol2qm74 1743 50 and and CC cord-015021-pol2qm74 1743 51 non non JJ cord-015021-pol2qm74 1743 52 - - JJ cord-015021-pol2qm74 1743 53 septic septic JJ cord-015021-pol2qm74 1743 54 burn burn NN cord-015021-pol2qm74 1743 55 patients patient NNS cord-015021-pol2qm74 1743 56 ( ( -LRB- cord-015021-pol2qm74 1743 57 > > NFP cord-015021-pol2qm74 1743 58 30~ 30~ CD cord-015021-pol2qm74 1743 59 ; ; : cord-015021-pol2qm74 1743 60 total total JJ cord-015021-pol2qm74 1743 61 body body NN cord-015021-pol2qm74 1743 62 surface surface NN cord-015021-pol2qm74 1743 63 area area NN cord-015021-pol2qm74 1743 64 , , , cord-015021-pol2qm74 1743 65 > > XX cord-015021-pol2qm74 1744 1 lS~ lS~ NNP cord-015021-pol2qm74 1744 2 full full JJ cord-015021-pol2qm74 1744 3 thickness thickness NN cord-015021-pol2qm74 1744 4 ) ) -RRB- cord-015021-pol2qm74 1745 1 , , , cord-015021-pol2qm74 1745 2 The the DT cord-015021-pol2qm74 1745 3 PMNs pmn NNS cord-015021-pol2qm74 1745 4 were be VBD cord-015021-pol2qm74 1745 5 Incubated incubate VBN cord-015021-pol2qm74 1745 6 with with IN cord-015021-pol2qm74 1745 7 LPS LPS NNP cord-015021-pol2qm74 1745 8 ( ( -LRB- cord-015021-pol2qm74 1745 9 ] ] -RRB- cord-015021-pol2qm74 1745 10 ng-10p.g ng-10p.g JJ cord-015021-pol2qm74 1745 11 / / SYM cord-015021-pol2qm74 1745 12 ml ml NN cord-015021-pol2qm74 1745 13 ) ) -RRB- cord-015021-pol2qm74 1745 14 or or CC cord-015021-pol2qm74 1745 15 f'MLP f'MLP NNP cord-015021-pol2qm74 1745 16 ( ( -LRB- cord-015021-pol2qm74 1745 17 10 10 CD cord-015021-pol2qm74 1745 18 " " `` cord-015021-pol2qm74 1745 19 1 1 CD cord-015021-pol2qm74 1745 20 1 1 CD cord-015021-pol2qm74 1745 21 to to IN cord-015021-pol2qm74 1745 22 10"6 10"6 CD cord-015021-pol2qm74 1745 23 M M NNP cord-015021-pol2qm74 1745 24 ) ) -RRB- cord-015021-pol2qm74 1745 25 et et FW cord-015021-pol2qm74 1745 26 37oc 37oc NN cord-015021-pol2qm74 1745 27 for for IN cord-015021-pol2qm74 1745 28 30 30 CD cord-015021-pol2qm74 1745 29 mln mln NNS cord-015021-pol2qm74 1745 30 , , , cord-015021-pol2qm74 1745 31 In in IN cord-015021-pol2qm74 1745 32 1~ 1~ CD cord-015021-pol2qm74 1745 33 ; ; : cord-015021-pol2qm74 1745 34 human human JJ cord-015021-pol2qm74 1745 35 AB AB NNP cord-015021-pol2qm74 1745 36 serum serum NN cord-015021-pol2qm74 1745 37 , , , cord-015021-pol2qm74 1745 38 The the DT cord-015021-pol2qm74 1745 39 expression expression NN cord-015021-pol2qm74 1745 40 of of IN cord-015021-pol2qm74 1745 41 the the DT cord-015021-pol2qm74 1745 42 132 132 CD cord-015021-pol2qm74 1745 43 ] ] -RRB- cord-015021-pol2qm74 1745 44 ntegrins ntegrin NNS cord-015021-pol2qm74 1745 45 was be VBD cord-015021-pol2qm74 1745 46 detected detect VBN cord-015021-pol2qm74 1745 47 using use VBG cord-015021-pol2qm74 1745 48 monoclonat monoclonat NNP cord-015021-pol2qm74 1745 49 antibodies antibody NNS cord-015021-pol2qm74 1745 50 and and CC cord-015021-pol2qm74 1745 51 flow flow NN cord-015021-pol2qm74 1745 52 cytometry cytometry NN cord-015021-pol2qm74 1745 53 . . . cord-015021-pol2qm74 1746 1 LPS LPS NNP cord-015021-pol2qm74 1746 2 and and CC cord-015021-pol2qm74 1746 3 f'MLP f'MLP NNP cord-015021-pol2qm74 1746 4 resulted result VBD cord-015021-pol2qm74 1746 5 In in IN cord-015021-pol2qm74 1746 6 a a DT cord-015021-pol2qm74 1746 7 slight slight JJ cord-015021-pol2qm74 1746 8 Increase increase NN cord-015021-pol2qm74 1746 9 ( ( -LRB- cord-015021-pol2qm74 1746 10 3 3 CD cord-015021-pol2qm74 1746 11 fold fold VB cord-015021-pol2qm74 1746 12 ) ) -RRB- cord-015021-pol2qm74 1746 13 In in IN cord-015021-pol2qm74 1746 14 the the DT cord-015021-pol2qm74 1746 15 expression expression NN cord-015021-pol2qm74 1746 16 of of IN cord-015021-pol2qm74 1746 17 CD11b CD11b NNS cord-015021-pol2qm74 1746 18 on on IN cord-015021-pol2qm74 1746 19 PMNS PMNS NNP cord-015021-pol2qm74 1746 20 from from IN cord-015021-pol2qm74 1746 21 burned burn VBN cord-015021-pol2qm74 1746 22 patients patient NNS cord-015021-pol2qm74 1746 23 compared compare VBN cord-015021-pol2qm74 1746 24 to to IN cord-015021-pol2qm74 1746 25 an an DT cord-015021-pol2qm74 1746 26 8 8 CD cord-015021-pol2qm74 1746 27 and and CC cord-015021-pol2qm74 1746 28 14 14 CD cord-015021-pol2qm74 1746 29 fold fold JJ cord-015021-pol2qm74 1746 30 increase increase NN cord-015021-pol2qm74 1746 31 , , , cord-015021-pol2qm74 1746 32 respectively respectively RB cord-015021-pol2qm74 1746 33 , , , cord-015021-pol2qm74 1746 34 on on IN cord-015021-pol2qm74 1746 35 PMNs pmn NNS cord-015021-pol2qm74 1746 36 from from IN cord-015021-pol2qm74 1746 37 healthy healthy JJ cord-015021-pol2qm74 1746 38 individuals individual NNS cord-015021-pol2qm74 1746 39 . . . cord-015021-pol2qm74 1747 1 This this DT cord-015021-pol2qm74 1747 2 Inability Inability NNP cord-015021-pol2qm74 1747 3 of of IN cord-015021-pol2qm74 1747 4 LPS LPS NNP cord-015021-pol2qm74 1747 5 or or CC cord-015021-pol2qm74 1747 6 fMLP fmlp NN cord-015021-pol2qm74 1747 7 to to TO cord-015021-pol2qm74 1747 8 increase increase VB cord-015021-pol2qm74 1747 9 CD11 CD11 NNP cord-015021-pol2qm74 1747 10 b b CD cord-015021-pol2qm74 1747 11 expression expression NN cord-015021-pol2qm74 1747 12 was be VBD cord-015021-pol2qm74 1747 13 not not RB cord-015021-pol2qm74 1747 14 due due JJ cord-015021-pol2qm74 1747 15 to to IN cord-015021-pol2qm74 1747 16 the the DT cord-015021-pol2qm74 1747 17 amount amount NN cord-015021-pol2qm74 1747 18 of of IN cord-015021-pol2qm74 1747 19 LPS lp NNS cord-015021-pol2qm74 1747 20 bound bind VBN cord-015021-pol2qm74 1747 21 to to IN cord-015021-pol2qm74 1747 22 the the DT cord-015021-pol2qm74 1747 23 two two CD cord-015021-pol2qm74 1747 24 cell cell NN cord-015021-pol2qm74 1747 25 populations population NNS cord-015021-pol2qm74 1747 26 . . . cord-015021-pol2qm74 1748 1 Because because IN cord-015021-pol2qm74 1748 2 the the DT cord-015021-pol2qm74 1748 3 same same JJ cord-015021-pol2qm74 1748 4 defect defect NN cord-015021-pol2qm74 1748 5 Is be VBZ cord-015021-pol2qm74 1748 6 seen see VBN cord-015021-pol2qm74 1748 7 after after IN cord-015021-pol2qm74 1748 8 either either DT cord-015021-pol2qm74 1748 9 LPS LPS NNP cord-015021-pol2qm74 1748 10 or or CC cord-015021-pol2qm74 1748 11 fMLP fmlp JJ cord-015021-pol2qm74 1748 12 stimulation stimulation NN cord-015021-pol2qm74 1748 13 , , , cord-015021-pol2qm74 1748 14 It -PRON- PRP cord-015021-pol2qm74 1748 15 Is be VBZ cord-015021-pol2qm74 1748 16 speculated speculate VBN cord-015021-pol2qm74 1748 17 that that IN cord-015021-pol2qm74 1748 18 the the DT cord-015021-pol2qm74 1748 19 defect defect NN cord-015021-pol2qm74 1748 20 must must MD cord-015021-pol2qm74 1748 21 be be VB cord-015021-pol2qm74 1748 22 in in IN cord-015021-pol2qm74 1748 23 the the DT cord-015021-pol2qm74 1748 24 amount amount NN cord-015021-pol2qm74 1748 25 of of IN cord-015021-pol2qm74 1748 26 preformed preformed JJ cord-015021-pol2qm74 1748 27 CD1 CD1 NNP cord-015021-pol2qm74 1748 28 ] ] -RRB- cord-015021-pol2qm74 1748 29 b b NN cord-015021-pol2qm74 1748 30 or or CC cord-015021-pol2qm74 1748 31 Its -PRON- PRP$ cord-015021-pol2qm74 1748 32 transport transport NN cord-015021-pol2qm74 1748 33 to to IN cord-015021-pol2qm74 1748 34 the the DT cord-015021-pol2qm74 1748 35 plasma plasma NN cord-015021-pol2qm74 1748 36 membrane membrane NN cord-015021-pol2qm74 1748 37 . . . cord-015021-pol2qm74 1749 1 Platelet platelet NN cord-015021-pol2qm74 1749 2 - - HYPH cord-015021-pol2qm74 1749 3 activating activate VBG cord-015021-pol2qm74 1749 4 factor factor NN cord-015021-pol2qm74 1749 5 ( ( -LRB- cord-015021-pol2qm74 1749 6 PAF PAF NNP cord-015021-pol2qm74 1749 7 ) ) -RRB- cord-015021-pol2qm74 1749 8 and and CC cord-015021-pol2qm74 1749 9 neutrophils neutrophil NNS cord-015021-pol2qm74 1749 10 have have VBP cord-015021-pol2qm74 1749 11 been be VBN cord-015021-pol2qm74 1749 12 implicated implicate VBN cord-015021-pol2qm74 1749 13 in in IN cord-015021-pol2qm74 1749 14 the the DT cord-015021-pol2qm74 1749 15 patbophysiology patbophysiology NN cord-015021-pol2qm74 1749 16 of of IN cord-015021-pol2qm74 1749 17 ischemia ischemia NN cord-015021-pol2qm74 1749 18 - - HYPH cord-015021-pol2qm74 1749 19 repeffusion repeffusion NN cord-015021-pol2qm74 1749 20 injury injury NN cord-015021-pol2qm74 1749 21 , , , cord-015021-pol2qm74 1749 22 In in IN cord-015021-pol2qm74 1749 23 addition addition NN cord-015021-pol2qm74 1749 24 , , , cord-015021-pol2qm74 1749 25 PAF PAF NNP cord-015021-pol2qm74 1749 26 stimulates stimulate VBZ cord-015021-pol2qm74 1749 27 neutrophi neutrophi RB cord-015021-pol2qm74 1749 28 [ [ -LRB- cord-015021-pol2qm74 1749 29 ( ( -LRB- cord-015021-pol2qm74 1749 30 PMN pmn NN cord-015021-pol2qm74 1749 31 ) ) -RRB- cord-015021-pol2qm74 1749 32 oxidative oxidative JJ cord-015021-pol2qm74 1749 33 metabolism metabolism NN cord-015021-pol2qm74 1749 34 in in IN cord-015021-pol2qm74 1749 35 vitro vitro FW cord-015021-pol2qm74 1749 36 . . . cord-015021-pol2qm74 1750 1 The the DT cord-015021-pol2qm74 1750 2 present present JJ cord-015021-pol2qm74 1750 3 study study NN cord-015021-pol2qm74 1750 4 examined examine VBD cord-015021-pol2qm74 1750 5 the the DT cord-015021-pol2qm74 1750 6 potential potential JJ cord-015021-pol2qm74 1750 7 role role NN cord-015021-pol2qm74 1750 8 of of IN cord-015021-pol2qm74 1750 9 PAF PAF NNP cord-015021-pol2qm74 1750 10 in in IN cord-015021-pol2qm74 1750 11 repeffusion repeffusion NN cord-015021-pol2qm74 1750 12 injury injury NN cord-015021-pol2qm74 1750 13 in in IN cord-015021-pol2qm74 1750 14 an an DT cord-015021-pol2qm74 1750 15 in in IN cord-015021-pol2qm74 1750 16 viva viva FW cord-015021-pol2qm74 1750 17 rabbit rabbit NN cord-015021-pol2qm74 1750 18 model model NN cord-015021-pol2qm74 1750 19 . . . cord-015021-pol2qm74 1751 1 Eight eight CD cord-015021-pol2qm74 1751 2 anesthetized anesthetize VBN cord-015021-pol2qm74 1751 3 rabbi~ rabbi~ NNS cord-015021-pol2qm74 1752 1 s s POS cord-015021-pol2qm74 1752 2 underwent undergo VBD cord-015021-pol2qm74 1752 3 retroperitoneal retroperitoneal JJ cord-015021-pol2qm74 1752 4 exposure exposure NN cord-015021-pol2qm74 1752 5 of of IN cord-015021-pol2qm74 1752 6 the the DT cord-015021-pol2qm74 1752 7 infrarenal infrarenal JJ cord-015021-pol2qm74 1752 8 abdominal abdominal NNP cord-015021-pol2qm74 1752 9 aorta aorta NN cord-015021-pol2qm74 1752 10 after after IN cord-015021-pol2qm74 1752 11 percutaneous percutaneous JJ cord-015021-pol2qm74 1752 12 insertion insertion NN cord-015021-pol2qm74 1752 13 of of IN cord-015021-pol2qm74 1752 14 a a DT cord-015021-pol2qm74 1752 15 catheter catheter NN cord-015021-pol2qm74 1752 16 through through IN cord-015021-pol2qm74 1752 17 the the DT cord-015021-pol2qm74 1752 18 jugular jugular NN cord-015021-pol2qm74 1752 19 vein vein NN cord-015021-pol2qm74 1752 20 into into IN cord-015021-pol2qm74 1752 21 the the DT cord-015021-pol2qm74 1752 22 infrahepatic infrahepatic JJ cord-015021-pol2qm74 1752 23 inferior inferior JJ cord-015021-pol2qm74 1752 24 vena vena FW cord-015021-pol2qm74 1752 25 cava cava NN cord-015021-pol2qm74 1752 26 . . . cord-015021-pol2qm74 1753 1 Doppler Doppler NNP cord-015021-pol2qm74 1753 2 flow flow NN cord-015021-pol2qm74 1753 3 probes probe NNS cord-015021-pol2qm74 1753 4 were be VBD cord-015021-pol2qm74 1753 5 placed place VBN cord-015021-pol2qm74 1753 6 around around IN cord-015021-pol2qm74 1753 7 the the DT cord-015021-pol2qm74 1753 8 abdominal abdominal JJ cord-015021-pol2qm74 1753 9 aorta aorta NN cord-015021-pol2qm74 1753 10 and and CC cord-015021-pol2qm74 1753 11 the the DT cord-015021-pol2qm74 1753 12 right right JJ cord-015021-pol2qm74 1753 13 common common JJ cord-015021-pol2qm74 1753 14 femoral femoral JJ cord-015021-pol2qm74 1753 15 artery artery NN cord-015021-pol2qm74 1753 16 to to TO cord-015021-pol2qm74 1753 17 assess assess VB cord-015021-pol2qm74 1753 18 flow flow NN cord-015021-pol2qm74 1753 19 through through IN cord-015021-pol2qm74 1753 20 these these DT cord-015021-pol2qm74 1753 21 vessels vessel NNS cord-015021-pol2qm74 1753 22 . . . cord-015021-pol2qm74 1754 1 An an DT cord-015021-pol2qm74 1754 2 occlusive occlusive JJ cord-015021-pol2qm74 1754 3 ligature ligature NN cord-015021-pol2qm74 1754 4 was be VBD cord-015021-pol2qm74 1754 5 placed place VBN cord-015021-pol2qm74 1754 6 around around IN cord-015021-pol2qm74 1754 7 the the DT cord-015021-pol2qm74 1754 8 abdominal abdominal JJ cord-015021-pol2qm74 1754 9 aorta aorta NN cord-015021-pol2qm74 1754 10 ( ( -LRB- cord-015021-pol2qm74 1754 11 superior superior JJ cord-015021-pol2qm74 1754 12 to to IN cord-015021-pol2qm74 1754 13 the the DT cord-015021-pol2qm74 1754 14 flow flow NN cord-015021-pol2qm74 1754 15 probe probe NN cord-015021-pol2qm74 1754 16 ) ) -RRB- cord-015021-pol2qm74 1754 17 at at IN cord-015021-pol2qm74 1754 18 t t NN cord-015021-pol2qm74 1754 19 = = SYM cord-015021-pol2qm74 1754 20 0 0 CD cord-015021-pol2qm74 1754 21 and and CC cord-015021-pol2qm74 1754 22 total total JJ cord-015021-pol2qm74 1754 23 occlusion occlusion NN cord-015021-pol2qm74 1754 24 of of IN cord-015021-pol2qm74 1754 25 blood blood NN cord-015021-pol2qm74 1754 26 flow flow NN cord-015021-pol2qm74 1754 27 to to IN cord-015021-pol2qm74 1754 28 the the DT cord-015021-pol2qm74 1754 29 lower low JJR cord-015021-pol2qm74 1754 30 extremities extremity NNS cord-015021-pol2qm74 1754 31 was be VBD cord-015021-pol2qm74 1754 32 maintained maintain VBN cord-015021-pol2qm74 1754 33 for for IN cord-015021-pol2qm74 1754 34 g0 g0 NN cord-015021-pol2qm74 1754 35 mins min NNS cord-015021-pol2qm74 1754 36 . . . cord-015021-pol2qm74 1755 1 , , , cord-015021-pol2qm74 1755 2 after after IN cord-015021-pol2qm74 1755 3 which which WDT cord-015021-pol2qm74 1755 4 the the DT cord-015021-pol2qm74 1755 5 ligature ligature NN cord-015021-pol2qm74 1755 6 was be VBD cord-015021-pol2qm74 1755 7 released release VBN cord-015021-pol2qm74 1755 8 allowing allow VBG cord-015021-pol2qm74 1755 9 for for IN cord-015021-pol2qm74 1755 10 reperfusion reperfusion NN cord-015021-pol2qm74 1755 11 of of IN cord-015021-pol2qm74 1755 12 the the DT cord-015021-pol2qm74 1755 13 ischemic ischemic JJ cord-015021-pol2qm74 1755 14 lower low JJR cord-015021-pol2qm74 1755 15 limbs limb NNS cord-015021-pol2qm74 1755 16 . . . cord-015021-pol2qm74 1756 1 Effluent effluent JJ cord-015021-pol2qm74 1756 2 blood blood NN cord-015021-pol2qm74 1756 3 from from IN cord-015021-pol2qm74 1756 4 the the DT cord-015021-pol2qm74 1756 5 ischemic ischemic JJ cord-015021-pol2qm74 1756 6 hind hind NN cord-015021-pol2qm74 1756 7 - - HYPH cord-015021-pol2qm74 1756 8 limbs limb NNS cord-015021-pol2qm74 1756 9 was be VBD cord-015021-pol2qm74 1756 10 collected collect VBN cord-015021-pol2qm74 1756 11 through through IN cord-015021-pol2qm74 1756 12 the the DT cord-015021-pol2qm74 1756 13 IVC IVC NNP cord-015021-pol2qm74 1756 14 catheter catheter NN cord-015021-pol2qm74 1756 15 at at IN cord-015021-pol2qm74 1756 16 the the DT cord-015021-pol2qm74 1756 17 times time NNS cord-015021-pol2qm74 1756 18 indicated indicate VBN cord-015021-pol2qm74 1756 19 below below RB cord-015021-pol2qm74 1756 20 and and CC cord-015021-pol2qm74 1756 21 assayed assay VBN cord-015021-pol2qm74 1756 22 for for IN cord-015021-pol2qm74 1756 23 PAF PAF NNP cord-015021-pol2qm74 1756 24 by by IN cord-015021-pol2qm74 1756 25 a a DT cord-015021-pol2qm74 1756 26 direct direct JJ cord-015021-pol2qm74 1756 27 radioimmunoassay radioimmunoassay NN cord-015021-pol2qm74 1756 28 . . . cord-015021-pol2qm74 1757 1 In in IN cord-015021-pol2qm74 1757 2 addition addition NN cord-015021-pol2qm74 1757 3 , , , cord-015021-pol2qm74 1757 4 neutrophil neutrophil NN cord-015021-pol2qm74 1757 5 H202 h202 NN cord-015021-pol2qm74 1757 6 production production NN cord-015021-pol2qm74 1757 7 was be VBD cord-015021-pol2qm74 1757 8 determined determine VBN cord-015021-pol2qm74 1757 9 by by IN cord-015021-pol2qm74 1757 10 a a DT cord-015021-pol2qm74 1757 11 previously previously RB cord-015021-pol2qm74 1757 12 described describe VBN cord-015021-pol2qm74 1757 13 2'7'-dichlorofluorescein 2'7'-dichlorofluorescein CD cord-015021-pol2qm74 1757 14 flowcytametric flowcytametric JJ cord-015021-pol2qm74 1757 15 assay assay NN cord-015021-pol2qm74 1757 16 . . . cord-015021-pol2qm74 1758 1 185 185 CD cord-015021-pol2qm74 1758 2 _ _ NN cord-015021-pol2qm74 1758 3 + + SYM cord-015021-pol2qm74 1758 4 53 53 CD cord-015021-pol2qm74 1758 5 amean amean NNP cord-015021-pol2qm74 1759 1 _ _ NNP cord-015021-pol2qm74 1759 2 + + CC cord-015021-pol2qm74 1760 1 s.e.m s.e.m NNP cord-015021-pol2qm74 1760 2 , , , cord-015021-pol2qm74 1760 3 pg pg NNP cord-015021-pol2qm74 1760 4 / / SYM cord-015021-pol2qm74 1760 5 ml ml IN cord-015021-pol2qm74 1760 6 blood blood NN cord-015021-pol2qm74 1760 7 ; ; : cord-015021-pol2qm74 1760 8 brelative brelative NNP cord-015021-pol2qm74 1760 9 fluoresenee fluoresenee NNP cord-015021-pol2qm74 1760 10 ( ( -LRB- cord-015021-pol2qm74 1760 11 % % NN cord-015021-pol2qm74 1760 12 of of IN cord-015021-pol2qm74 1760 13 baseline baseline NN cord-015021-pol2qm74 1760 14 ) ) -RRB- cord-015021-pol2qm74 1760 15 ; ; : cord-015021-pol2qm74 1760 16 Caortic caortic JJ cord-015021-pol2qm74 1760 17 and and CC cord-015021-pol2qm74 1760 18 femoral femoral JJ cord-015021-pol2qm74 1760 19 artery artery NN cord-015021-pol2qm74 1760 20 flow flow NN cord-015021-pol2qm74 1760 21 ( ( -LRB- cord-015021-pol2qm74 1760 22 % % NN cord-015021-pol2qm74 1760 23 of of IN cord-015021-pol2qm74 1760 24 baseline baseline NN cord-015021-pol2qm74 1760 25 ) ) -RRB- cord-015021-pol2qm74 1760 26 ; ; : cord-015021-pol2qm74 1761 1 * * NFP cord-015021-pol2qm74 1761 2 p p XX cord-015021-pol2qm74 1761 3 < < XX cord-015021-pol2qm74 1761 4 0.01 0.01 CD cord-015021-pol2qm74 1761 5 vs. vs. IN cord-015021-pol2qm74 1761 6 baseline baseline NN cord-015021-pol2qm74 1761 7 ; ; : cord-015021-pol2qm74 1761 8 1"p 1"p CD cord-015021-pol2qm74 1761 9 < < XX cord-015021-pol2qm74 1761 10 0.05 0.05 CD cord-015021-pol2qm74 1761 11 vs. vs. IN cord-015021-pol2qm74 1761 12 baseline baseline NN cord-015021-pol2qm74 1761 13 . . . cord-015021-pol2qm74 1762 1 A a DT cord-015021-pol2qm74 1762 2 significant significant JJ cord-015021-pol2qm74 1762 3 elevation elevation NN cord-015021-pol2qm74 1762 4 of of IN cord-015021-pol2qm74 1762 5 PAF PAF NNP cord-015021-pol2qm74 1762 6 was be VBD cord-015021-pol2qm74 1762 7 observed observe VBN cord-015021-pol2qm74 1762 8 in in IN cord-015021-pol2qm74 1762 9 ischemic ischemic JJ cord-015021-pol2qm74 1762 10 hind hind JJ cord-015021-pol2qm74 1762 11 - - HYPH cord-015021-pol2qm74 1762 12 limb limb NN cord-015021-pol2qm74 1762 13 effluent effluent NN cord-015021-pol2qm74 1762 14 blood blood NN cord-015021-pol2qm74 1762 15 at at IN cord-015021-pol2qm74 1762 16 15 15 CD cord-015021-pol2qm74 1762 17 min min NN cord-015021-pol2qm74 1762 18 . . . cord-015021-pol2qm74 1763 1 after after IN cord-015021-pol2qm74 1763 2 release release NN cord-015021-pol2qm74 1763 3 of of IN cord-015021-pol2qm74 1763 4 the the DT cord-015021-pol2qm74 1763 5 aortic aortic JJ cord-015021-pol2qm74 1763 6 ligature ligature NN cord-015021-pol2qm74 1763 7 during during IN cord-015021-pol2qm74 1763 8 the the DT cord-015021-pol2qm74 1763 9 repeffusion repeffusion NN cord-015021-pol2qm74 1763 10 phase phase NN cord-015021-pol2qm74 1763 11 , , , cord-015021-pol2qm74 1763 12 as as IN cord-015021-pol2qm74 1763 13 compared compare VBN cord-015021-pol2qm74 1763 14 to to IN cord-015021-pol2qm74 1763 15 baseline baseline JJ cord-015021-pol2qm74 1763 16 levels level NNS cord-015021-pol2qm74 1763 17 . . . cord-015021-pol2qm74 1764 1 In in IN cord-015021-pol2qm74 1764 2 addition addition NN cord-015021-pol2qm74 1764 3 , , , cord-015021-pol2qm74 1764 4 PMN PMN NNP cord-015021-pol2qm74 1764 5 H20 H20 NNP cord-015021-pol2qm74 1764 6 2 2 CD cord-015021-pol2qm74 1764 7 production production NN cord-015021-pol2qm74 1764 8 was be VBD cord-015021-pol2qm74 1764 9 increased increase VBN cord-015021-pol2qm74 1764 10 by by IN cord-015021-pol2qm74 1764 11 2.3-fold 2.3-fold CD cord-015021-pol2qm74 1764 12 above above IN cord-015021-pol2qm74 1764 13 baseline baseline JJ cord-015021-pol2qm74 1764 14 values value NNS cord-015021-pol2qm74 1764 15 by by IN cord-015021-pol2qm74 1764 16 1 1 CD cord-015021-pol2qm74 1764 17 hour hour NN cord-015021-pol2qm74 1764 18 after after IN cord-015021-pol2qm74 1764 19 ligature ligature NN cord-015021-pol2qm74 1764 20 release release NN cord-015021-pol2qm74 1764 21 during during IN cord-015021-pol2qm74 1764 22 the the DT cord-015021-pol2qm74 1764 23 reperfusion reperfusion NN cord-015021-pol2qm74 1764 24 phase phase NN cord-015021-pol2qm74 1764 25 . . . cord-015021-pol2qm74 1765 1 Both both DT cord-015021-pol2qm74 1765 2 of of IN cord-015021-pol2qm74 1765 3 these these DT cord-015021-pol2qm74 1765 4 elevations elevation NNS cord-015021-pol2qm74 1765 5 were be VBD cord-015021-pol2qm74 1765 6 transient transient JJ cord-015021-pol2qm74 1765 7 and and CC cord-015021-pol2qm74 1765 8 returned return VBD cord-015021-pol2qm74 1765 9 toward toward IN cord-015021-pol2qm74 1765 10 baseline baseline NN cord-015021-pol2qm74 1765 11 by by IN cord-015021-pol2qm74 1765 12 2 2 CD cord-015021-pol2qm74 1765 13 hours hour NNS cord-015021-pol2qm74 1765 14 post post NN cord-015021-pol2qm74 1765 15 - - NN cord-015021-pol2qm74 1765 16 isehemia isehemia JJ cord-015021-pol2qm74 1765 17 . . . cord-015021-pol2qm74 1766 1 Tatar Tatar NNP cord-015021-pol2qm74 1766 2 occlusion occlusion NN cord-015021-pol2qm74 1766 3 of of IN cord-015021-pol2qm74 1766 4 hind hind JJ cord-015021-pol2qm74 1766 5 - - HYPH cord-015021-pol2qm74 1766 6 limb limb NN cord-015021-pol2qm74 1766 7 flow flow NN cord-015021-pol2qm74 1766 8 was be VBD cord-015021-pol2qm74 1766 9 achieved achieve VBN cord-015021-pol2qm74 1766 10 as as IN cord-015021-pol2qm74 1766 11 evidenced evidence VBN cord-015021-pol2qm74 1766 12 by by IN cord-015021-pol2qm74 1766 13 the the DT cord-015021-pol2qm74 1766 14 absence absence NN cord-015021-pol2qm74 1766 15 of of IN cord-015021-pol2qm74 1766 16 aortic aortic JJ cord-015021-pol2qm74 1766 17 or or CC cord-015021-pol2qm74 1766 18 femorat femorat NN cord-015021-pol2qm74 1766 19 flow flow NN cord-015021-pol2qm74 1766 20 at at IN cord-015021-pol2qm74 1766 21 90 90 CD cord-015021-pol2qm74 1766 22 rain rain NN cord-015021-pol2qm74 1766 23 . . . cord-015021-pol2qm74 1767 1 post post JJ cord-015021-pol2qm74 1767 2 - - JJ cord-015021-pol2qm74 1767 3 ischemia ischemia JJ cord-015021-pol2qm74 1767 4 , , , cord-015021-pol2qm74 1767 5 however however RB cord-015021-pol2qm74 1767 6 after after IN cord-015021-pol2qm74 1767 7 release release NN cord-015021-pol2qm74 1767 8 01 01 CD cord-015021-pol2qm74 1767 9 the the DT cord-015021-pol2qm74 1767 10 ligature ligature NN cord-015021-pol2qm74 1767 11 a a DT cord-015021-pol2qm74 1767 12 significant significant JJ cord-015021-pol2qm74 1767 13 reactive reactive JJ cord-015021-pol2qm74 1767 14 hyperemia hyperemia NN cord-015021-pol2qm74 1767 15 was be VBD cord-015021-pol2qm74 1767 16 observed observe VBN cord-015021-pol2qm74 1767 17 by by IN cord-015021-pol2qm74 1767 18 15 15 CD cord-015021-pol2qm74 1767 19 mln mln NNS cord-015021-pol2qm74 1767 20 . . . cord-015021-pol2qm74 1768 1 into into IN cord-015021-pol2qm74 1768 2 the the DT cord-015021-pol2qm74 1768 3 rapeffusion rapeffusion NN cord-015021-pol2qm74 1768 4 phase phase NN cord-015021-pol2qm74 1768 5 . . . cord-015021-pol2qm74 1769 1 Histolog[c histolog[c NN cord-015021-pol2qm74 1769 2 examination examination NN cord-015021-pol2qm74 1769 3 of of IN cord-015021-pol2qm74 1769 4 reper[used reper[used JJ cord-015021-pol2qm74 1769 5 gastrocnemius gastrocnemius NN cord-015021-pol2qm74 1769 6 muscle muscle NN cord-015021-pol2qm74 1769 7 revealed reveal VBD cord-015021-pol2qm74 1769 8 moderate moderate JJ cord-015021-pol2qm74 1769 9 PMN PMN NNP cord-015021-pol2qm74 1769 10 infiltration infiltration NN cord-015021-pol2qm74 1769 11 into into IN cord-015021-pol2qm74 1769 12 the the DT cord-015021-pol2qm74 1769 13 interstitium interstitium NN cord-015021-pol2qm74 1769 14 . . . cord-015021-pol2qm74 1770 1 In in IN cord-015021-pol2qm74 1770 2 conclusion conclusion NN cord-015021-pol2qm74 1770 3 , , , cord-015021-pol2qm74 1770 4 these these DT cord-015021-pol2qm74 1770 5 data datum NNS cord-015021-pol2qm74 1770 6 indicate indicate VBP cord-015021-pol2qm74 1770 7 that that IN cord-015021-pol2qm74 1770 8 PAF PAF NNP cord-015021-pol2qm74 1770 9 is be VBZ cord-015021-pol2qm74 1770 10 released release VBN cord-015021-pol2qm74 1770 11 into into IN cord-015021-pol2qm74 1770 12 the the DT cord-015021-pol2qm74 1770 13 circulation circulation NN cord-015021-pol2qm74 1770 14 during during IN cord-015021-pol2qm74 1770 15 repeffusion repeffusion NN cord-015021-pol2qm74 1770 16 , , , cord-015021-pol2qm74 1770 17 and and CC cord-015021-pol2qm74 1770 18 is be VBZ cord-015021-pol2qm74 1770 19 likely likely RB cord-015021-pol2qm74 1770 20 involved involve VBN cord-015021-pol2qm74 1770 21 as as IN cord-015021-pol2qm74 1770 22 a a DT cord-015021-pol2qm74 1770 23 mediator mediator NN cord-015021-pol2qm74 1770 24 in in IN cord-015021-pol2qm74 1770 25 the the DT cord-015021-pol2qm74 1770 26 observed observe VBN cord-015021-pol2qm74 1770 27 PMN PMN NNP cord-015021-pol2qm74 1770 28 oxidative oxidative JJ cord-015021-pol2qm74 1770 29 burst burst NN cord-015021-pol2qm74 1770 30 activity activity NN cord-015021-pol2qm74 1770 31 , , , cord-015021-pol2qm74 1770 32 thereby thereby RB cord-015021-pol2qm74 1770 33 contributing contribute VBG cord-015021-pol2qm74 1770 34 to to IN cord-015021-pol2qm74 1770 35 reperfusien reperfusien NNP cord-015021-pol2qm74 1770 36 injury injury NN cord-015021-pol2qm74 1770 37 . . . cord-015021-pol2qm74 1771 1 Following follow VBG cord-015021-pol2qm74 1771 2 thermal thermal JJ cord-015021-pol2qm74 1771 3 Injury injury NN cord-015021-pol2qm74 1771 4 and and CC cord-015021-pol2qm74 1771 5 Infection Infection NNP cord-015021-pol2qm74 1771 6 granulocyte granulocyte NN cord-015021-pol2qm74 1771 7 function function NN cord-015021-pol2qm74 1771 8 ts ts XX cord-015021-pol2qm74 1771 9 abnormal abnormal JJ cord-015021-pol2qm74 1771 10 . . . cord-015021-pol2qm74 1772 1 To to TO cord-015021-pol2qm74 1772 2 elucidate elucidate VB cord-015021-pol2qm74 1772 3 the the DT cord-015021-pol2qm74 1772 4 mechanism mechanism NN cord-015021-pol2qm74 1772 5 by by IN cord-015021-pol2qm74 1772 6 which which WDT cord-015021-pol2qm74 1772 7 thermal thermal JJ cord-015021-pol2qm74 1772 8 injury injury NN cord-015021-pol2qm74 1772 9 and and CC cord-015021-pol2qm74 1772 10 Infection Infection NNP cord-015021-pol2qm74 1772 11 affect affect VBP cord-015021-pol2qm74 1772 12 the the DT cord-015021-pol2qm74 1772 13 granulocyte granulocyte NN cord-015021-pol2qm74 1772 14 's 's POS cord-015021-pol2qm74 1772 15 ability ability NN cord-015021-pol2qm74 1772 16 to to TO cord-015021-pol2qm74 1772 17 polymerize polymerize VB cord-015021-pol2qm74 1772 18 and and CC cord-015021-pol2qm74 1772 19 depolymedze depolymedze NNP cord-015021-pol2qm74 1772 20 actin actin NNP cord-015021-pol2qm74 1772 21 , , , cord-015021-pol2qm74 1772 22 we -PRON- PRP cord-015021-pol2qm74 1772 23 serially serially RB cord-015021-pol2qm74 1772 24 measured measure VBD cord-015021-pol2qm74 1772 25 F F NNP cord-015021-pol2qm74 1772 26 - - HYPH cord-015021-pol2qm74 1772 27 Actin Actin NNP cord-015021-pol2qm74 1772 28 levels level NNS cord-015021-pol2qm74 1772 29 in in IN cord-015021-pol2qm74 1772 30 granulocytes granulocyte NNS cord-015021-pol2qm74 1772 31 from from IN cord-015021-pol2qm74 1772 32 14 14 CD cord-015021-pol2qm74 1772 33 burned burn VBN cord-015021-pol2qm74 1772 34 patients patient NNS cord-015021-pol2qm74 1772 35 ( ( -LRB- cord-015021-pol2qm74 1772 36 mean mean VB cord-015021-pol2qm74 1772 37 age age NN cord-015021-pol2qm74 1772 38 42,1 42,1 CD cord-015021-pol2qm74 1773 1 + + CC cord-015021-pol2qm74 1774 1 _ _ NN cord-015021-pol2qm74 1774 2 17.7 17.7 CD cord-015021-pol2qm74 1774 3 years year NNS cord-015021-pol2qm74 1774 4 , , , cord-015021-pol2qm74 1774 5 mean mean VB cord-015021-pol2qm74 1774 6 burn burn NN cord-015021-pol2qm74 1774 7 size size NN cord-015021-pol2qm74 1774 8 39.8 39.8 CD cord-015021-pol2qm74 1774 9 % % NN cord-015021-pol2qm74 1775 1 _ _ NN cord-015021-pol2qm74 1775 2 + + SYM cord-015021-pol2qm74 1775 3 22.2 22.2 CD cord-015021-pol2qm74 1775 4 % % NN cord-015021-pol2qm74 1775 5 ) ) -RRB- cord-015021-pol2qm74 1775 6 during during IN cord-015021-pol2qm74 1775 7 the the DT cord-015021-pol2qm74 1775 8 first first JJ cord-015021-pol2qm74 1775 9 S S NNP cord-015021-pol2qm74 1775 10 weeks week NNS cord-015021-pol2qm74 1775 11 post post NN cord-015021-pol2qm74 1775 12 injury injury NN cord-015021-pol2qm74 1775 13 . . . cord-015021-pol2qm74 1776 1 Six six CD cord-015021-pol2qm74 1776 2 of of IN cord-015021-pol2qm74 1776 3 the the DT cord-015021-pol2qm74 1776 4 patients patient NNS cord-015021-pol2qm74 1776 5 had have VBD cord-015021-pol2qm74 1776 6 infections infection NNS cord-015021-pol2qm74 1776 7 during during IN cord-015021-pol2qm74 1776 8 the the DT cord-015021-pol2qm74 1776 9 course course NN cord-015021-pol2qm74 1776 10 of of IN cord-015021-pol2qm74 1776 11 the the DT cord-015021-pol2qm74 1776 12 study study NN cord-015021-pol2qm74 1776 13 , , , cord-015021-pol2qm74 1776 14 ( ( -LRB- cord-015021-pol2qm74 1776 15 septicemia septicemia NN cord-015021-pol2qm74 1776 16 , , , cord-015021-pol2qm74 1776 17 wound wound JJ cord-015021-pol2qm74 1776 18 Invasion invasion NN cord-015021-pol2qm74 1776 19 and and CC cord-015021-pol2qm74 1776 20 pneumonia pneumonia NN cord-015021-pol2qm74 1776 21 ) ) -RRB- cord-015021-pol2qm74 1776 22 . . . cord-015021-pol2qm74 1777 1 Actin actin NN cord-015021-pol2qm74 1777 2 levels level NNS cord-015021-pol2qm74 1778 1 In in IN cord-015021-pol2qm74 1778 2 granulocytes granulocyte NNS cord-015021-pol2qm74 1778 3 from from IN cord-015021-pol2qm74 1778 4 eleven eleven CD cord-015021-pol2qm74 1778 5 healthy healthy JJ cord-015021-pol2qm74 1778 6 volunteers volunteer NNS cord-015021-pol2qm74 1778 7 ( ( -LRB- cord-015021-pol2qm74 1778 8 mean mean VB cord-015021-pol2qm74 1778 9 age age NN cord-015021-pol2qm74 1778 10 34 34 CD cord-015021-pol2qm74 1778 11 years year NNS cord-015021-pol2qm74 1778 12 ) ) -RRB- cord-015021-pol2qm74 1778 13 were be VBD cord-015021-pol2qm74 1778 14 measured measure VBN cord-015021-pol2qm74 1778 15 repeatedly repeatedly RB cord-015021-pol2qm74 1778 16 and and CC cord-015021-pol2qm74 1778 17 served serve VBD cord-015021-pol2qm74 1778 18 as as IN cord-015021-pol2qm74 1778 19 controls control NNS cord-015021-pol2qm74 1778 20 . . . cord-015021-pol2qm74 1779 1 Lysecl Lysecl NNP cord-015021-pol2qm74 1779 2 white white JJ cord-015021-pol2qm74 1779 3 blood blood NN cord-015021-pol2qm74 1779 4 cell cell NN cord-015021-pol2qm74 1779 5 preparations preparation NNS cord-015021-pol2qm74 1779 6 were be VBD cord-015021-pol2qm74 1779 7 brought bring VBN cord-015021-pol2qm74 1779 8 to to IN cord-015021-pol2qm74 1779 9 370C 370c CD cord-015021-pol2qm74 1779 10 and and CC cord-015021-pol2qm74 1779 11 incubated incubate VBN cord-015021-pol2qm74 1779 12 with with IN cord-015021-pol2qm74 1779 13 N N NNP cord-015021-pol2qm74 1779 14 - - HYPH cord-015021-pol2qm74 1779 15 formyl formyl NNP cord-015021-pol2qm74 1779 16 - - HYPH cord-015021-pol2qm74 1779 17 met met NNP cord-015021-pol2qm74 1779 18 - - HYPH cord-015021-pol2qm74 1779 19 leu leu NN cord-015021-pol2qm74 1779 20 - - HYPH cord-015021-pol2qm74 1779 21 phe phe NNP cord-015021-pol2qm74 1779 22 ( ( -LRB- cord-015021-pol2qm74 1779 23 STIM STIM NNP cord-015021-pol2qm74 1779 24 ) ) -RRB- cord-015021-pol2qm74 1779 25 or or CC cord-015021-pol2qm74 1779 26 with with IN cord-015021-pol2qm74 1779 27 Dulbecco Dulbecco NNP cord-015021-pol2qm74 1779 28 's 's POS cord-015021-pol2qm74 1779 29 phosphate phosphate NN cord-015021-pol2qm74 1779 30 unbuffered unbuffered JJ cord-015021-pol2qm74 1779 31 sellne sellne NNP cord-015021-pol2qm74 1779 32 ( ( -LRB- cord-015021-pol2qm74 1779 33 UNSTIM UNSTIM NNP cord-015021-pol2qm74 1779 34 ) ) -RRB- cord-015021-pol2qm74 1779 35 . . . cord-015021-pol2qm74 1780 1 The the DT cord-015021-pol2qm74 1780 2 cells cell NNS cord-015021-pol2qm74 1780 3 were be VBD cord-015021-pol2qm74 1780 4 concomitantly concomitantly RB cord-015021-pol2qm74 1780 5 stained stain VBN cord-015021-pol2qm74 1780 6 and and CC cord-015021-pol2qm74 1780 7 fixed fix VBN cord-015021-pol2qm74 1780 8 with with IN cord-015021-pol2qm74 1780 9 formaldehyde formaldehyde NN cord-015021-pol2qm74 1780 10 , , , cord-015021-pol2qm74 1780 11 lysoleclthln lysoleclthln NNP cord-015021-pol2qm74 1780 12 and and CC cord-015021-pol2qm74 1780 13 fiuoresceln fiuoresceln NNP cord-015021-pol2qm74 1780 14 phafioidin phafioidin NNP cord-015021-pol2qm74 1780 15 . . . cord-015021-pol2qm74 1781 1 Actin actin NN cord-015021-pol2qm74 1781 2 depolymedzation depolymedzation NN cord-015021-pol2qm74 1781 3 ( ( -LRB- cord-015021-pol2qm74 1781 4 DEPOL DEPOL NNP cord-015021-pol2qm74 1781 5 ) ) -RRB- cord-015021-pol2qm74 1781 6 was be VBD cord-015021-pol2qm74 1781 7 measured measure VBN cord-015021-pol2qm74 1781 8 by by IN cord-015021-pol2qm74 1781 9 Incubating incubate VBG cord-015021-pol2qm74 1781 10 stimulated stimulated JJ cord-015021-pol2qm74 1781 11 cells cell NNS cord-015021-pol2qm74 1781 12 at at IN cord-015021-pol2qm74 1781 13 0 0 CD cord-015021-pol2qm74 1781 14 ° ° NN cord-015021-pol2qm74 1781 15 C c NN cord-015021-pol2qm74 1781 16 before before IN cord-015021-pol2qm74 1781 17 the the DT cord-015021-pol2qm74 1781 18 stain stain NN cord-015021-pol2qm74 1781 19 - - HYPH cord-015021-pol2qm74 1781 20 fixative fixative NN cord-015021-pol2qm74 1781 21 was be VBD cord-015021-pol2qm74 1781 22 added add VBN cord-015021-pol2qm74 1781 23 . . . cord-015021-pol2qm74 1782 1 Baseline baseline JJ cord-015021-pol2qm74 1782 2 ( ( -LRB- cord-015021-pol2qm74 1782 3 BASE base NN cord-015021-pol2qm74 1782 4 ) ) -RRB- cord-015021-pol2qm74 1783 1 F F NNP cord-015021-pol2qm74 1783 2 - - HYPH cord-015021-pol2qm74 1783 3 actln actln NN cord-015021-pol2qm74 1783 4 levels level NNS cord-015021-pol2qm74 1783 5 were be VBD cord-015021-pol2qm74 1783 6 assessed assess VBN cord-015021-pol2qm74 1783 7 by by IN cord-015021-pol2qm74 1783 8 adding add VBG cord-015021-pol2qm74 1783 9 stsln stsln NN cord-015021-pol2qm74 1783 10 - - HYPH cord-015021-pol2qm74 1783 11 fixatlve fixatlve NN cord-015021-pol2qm74 1783 12 to to IN cord-015021-pol2qm74 1783 13 Icecold Icecold NNP cord-015021-pol2qm74 1783 14 unstimulated unstimulated JJ cord-015021-pol2qm74 1783 15 cells cell NNS cord-015021-pol2qm74 1783 16 . . . cord-015021-pol2qm74 1784 1 Fluorescence fluorescence NN cord-015021-pol2qm74 1784 2 was be VBD cord-015021-pol2qm74 1784 3 estimated estimate VBN cord-015021-pol2qm74 1784 4 In in IN cord-015021-pol2qm74 1784 5 a a DT cord-015021-pol2qm74 1784 6 FACSCAN FACSCAN NNP cord-015021-pol2qm74 1784 7 and and CC cord-015021-pol2qm74 1784 8 expressed express VBD cord-015021-pol2qm74 1784 9 as as IN cord-015021-pol2qm74 1784 10 Ilnesr Ilnesr NNP cord-015021-pol2qm74 1784 11 mean mean VBP cord-015021-pol2qm74 1784 12 channel channel NNP cord-015021-pol2qm74 1784 13 fluorescence_+ fluorescence_+ VBZ cord-015021-pol2qm74 1784 14 SEM SEM NNP cord-015021-pol2qm74 1784 15 ( ( -LRB- cord-015021-pol2qm74 1784 16 MCF MCF NNP cord-015021-pol2qm74 1784 17 ) ) -RRB- cord-015021-pol2qm74 1784 18 . . . cord-015021-pol2qm74 1785 1 Figure figure NN cord-015021-pol2qm74 1785 2 1 1 CD cord-015021-pol2qm74 1785 3 displays display NNS cord-015021-pol2qm74 1786 1 granulecyle granulecyle NNP cord-015021-pol2qm74 1786 2 Fectln Fectln NNP cord-015021-pol2qm74 1786 3 levels level NNS cord-015021-pol2qm74 1786 4 In in IN cord-015021-pol2qm74 1786 5 Infected infected JJ cord-015021-pol2qm74 1786 6 and and CC cord-015021-pol2qm74 1786 7 uninfected uninfected JJ cord-015021-pol2qm74 1786 8 patients patient NNS cord-015021-pol2qm74 1787 1 as as IN cord-015021-pol2qm74 1787 2 compared compare VBN cord-015021-pol2qm74 1787 3 to to IN cord-015021-pol2qm74 1787 4 controls control NNS cord-015021-pol2qm74 1787 5 . . . cord-015021-pol2qm74 1788 1 F F NNP cord-015021-pol2qm74 1788 2 - - HYPH cord-015021-pol2qm74 1788 3 actln actln NN cord-015021-pol2qm74 1788 4 levels level NNS cord-015021-pol2qm74 1788 5 were be VBD cord-015021-pol2qm74 1788 6 consistently consistently RB cord-015021-pol2qm74 1788 7 lower low JJR cord-015021-pol2qm74 1788 8 In in IN cord-015021-pol2qm74 1788 9 control control NN cord-015021-pol2qm74 1788 10 cells cell NNS cord-015021-pol2qm74 1788 11 than than IN cord-015021-pol2qm74 1788 12 In in IN cord-015021-pol2qm74 1788 13 those those DT cord-015021-pol2qm74 1788 14 from from IN cord-015021-pol2qm74 1788 15 burned burn VBN cord-015021-pol2qm74 1788 16 or or CC cord-015021-pol2qm74 1788 17 burn burn VB cord-015021-pol2qm74 1788 18 - - HYPH cord-015021-pol2qm74 1788 19 infected infect VBN cord-015021-pol2qm74 1788 20 patients patient NNS cord-015021-pol2qm74 1788 21 under under IN cord-015021-pol2qm74 1788 22 all all DT cord-015021-pol2qm74 1788 23 measured measure VBN cord-015021-pol2qm74 1788 24 conditions condition NNS cord-015021-pol2qm74 1788 25 . . . cord-015021-pol2qm74 1789 1 Granulocytes granulocyte NNS cord-015021-pol2qm74 1789 2 from from IN cord-015021-pol2qm74 1789 3 Infected Infected NNP cord-015021-pol2qm74 1789 4 burned burn VBN cord-015021-pol2qm74 1789 5 patients patient NNS cord-015021-pol2qm74 1789 6 demonstrated demonstrate VBD cord-015021-pol2qm74 1789 7 a a DT cord-015021-pol2qm74 1789 8 significant significant JJ cord-015021-pol2qm74 1789 9 decrement decrement NN cord-015021-pol2qm74 1789 10 In in IN cord-015021-pol2qm74 1789 11 their -PRON- PRP$ cord-015021-pol2qm74 1789 12 ability ability NN cord-015021-pol2qm74 1789 13 to to TO cord-015021-pol2qm74 1789 14 depofymerlze depofymerlze NNP cord-015021-pol2qm74 1789 15 F.actin F.actin NNP cord-015021-pol2qm74 1789 16 compared compare VBN cord-015021-pol2qm74 1789 17 to to IN cord-015021-pol2qm74 1789 18 both both DT cord-015021-pol2qm74 1789 19 uninfected uninfected JJ cord-015021-pol2qm74 1789 20 burned burn VBD cord-015021-pol2qm74 1789 21 patients patient NNS cord-015021-pol2qm74 1789 22 and and CC cord-015021-pol2qm74 1789 23 controls control NNS cord-015021-pol2qm74 1789 24 , , , cord-015021-pol2qm74 1789 25 while while IN cord-015021-pol2qm74 1789 26 there there EX cord-015021-pol2qm74 1789 27 were be VBD cord-015021-pol2qm74 1789 28 no no DT cord-015021-pol2qm74 1789 29 significant significant JJ cord-015021-pol2qm74 1789 30 differences difference NNS cord-015021-pol2qm74 1789 31 between between IN cord-015021-pol2qm74 1789 32 Infected Infected NNP cord-015021-pol2qm74 1789 33 and and CC cord-015021-pol2qm74 1789 34 1,~ 1,~ CD cord-015021-pol2qm74 1789 35 uninfected uninfected JJ cord-015021-pol2qm74 1789 36 patients patient NNS cord-015021-pol2qm74 1789 37 In in IN cord-015021-pol2qm74 1789 38 the the DT cord-015021-pol2qm74 1789 39 baseline baseline NN cord-015021-pol2qm74 1789 40 , , , cord-015021-pol2qm74 1789 41 unstlmuleted unstlmuleted JJ cord-015021-pol2qm74 1789 42 and and CC cord-015021-pol2qm74 1789 43 stimulated stimulate VBN cord-015021-pol2qm74 1789 44 conditions condition NNS cord-015021-pol2qm74 1789 45 . . . cord-015021-pol2qm74 1790 1 Those those DT cord-015021-pol2qm74 1790 2 results result NNS cord-015021-pol2qm74 1790 3 Indicate indicate VBP cord-015021-pol2qm74 1790 4 la5 la5 NNS cord-015021-pol2qm74 1790 5 that that DT cord-015021-pol2qm74 1790 6 grsnulocytas grsnulocytas NN cord-015021-pol2qm74 1790 7 from from IN cord-015021-pol2qm74 1790 8 burned burned JJ cord-015021-pol2qm74 1790 9 and and CC cord-015021-pol2qm74 1790 10 bum bum NN cord-015021-pol2qm74 1790 11 - - HYPH cord-015021-pol2qm74 1790 12 Infected infect VBN cord-015021-pol2qm74 1790 13 patients patient NNS cord-015021-pol2qm74 1790 14 contain contain VBP cord-015021-pol2qm74 1790 15 higher high JJR cord-015021-pol2qm74 1790 16 levels level NNS cord-015021-pol2qm74 1790 17 of of IN cord-015021-pol2qm74 1790 18 polymerized polymerize VBN cord-015021-pol2qm74 1790 19 actln actln NN cord-015021-pol2qm74 1790 20 than than IN cord-015021-pol2qm74 1790 21 ~ ~ CD cord-015021-pol2qm74 1790 22 , , , cord-015021-pol2qm74 1790 23 2S 2s CD cord-015021-pol2qm74 1790 24 control control NN cord-015021-pol2qm74 1790 25 cells cell NNS cord-015021-pol2qm74 1790 26 . . . cord-015021-pol2qm74 1791 1 In in IN cord-015021-pol2qm74 1791 2 order order NN cord-015021-pol2qm74 1791 3 to to TO cord-015021-pol2qm74 1791 4 study study VB cord-015021-pol2qm74 1791 5 tumor tumor NN cord-015021-pol2qm74 1791 6 necrosis necrosis NN cord-015021-pol2qm74 1791 7 factor factor NN cord-015021-pol2qm74 1791 8 ( ( -LRB- cord-015021-pol2qm74 1791 9 TNF TNF NNP cord-015021-pol2qm74 1791 10 ) ) -RRB- cord-015021-pol2qm74 1791 11 receptor receptor NN cord-015021-pol2qm74 1791 12 sensitivity sensitivity NN cord-015021-pol2qm74 1791 13 in in IN cord-015021-pol2qm74 1791 14 septic septic NN cord-015021-pol2qm74 1791 15 critically critically RB cord-015021-pol2qm74 1791 16 ill ill JJ cord-015021-pol2qm74 1791 17 patients patient NNS cord-015021-pol2qm74 1791 18 we -PRON- PRP cord-015021-pol2qm74 1791 19 investigated investigate VBD cord-015021-pol2qm74 1791 20 20 20 CD cord-015021-pol2qm74 1791 21 blood blood NN cord-015021-pol2qm74 1791 22 samples sample NNS cord-015021-pol2qm74 1791 23 of of IN cord-015021-pol2qm74 1791 24 such such JJ cord-015021-pol2qm74 1791 25 people people NNS cord-015021-pol2qm74 1791 26 in in IN cord-015021-pol2qm74 1791 27 reaction reaction NN cord-015021-pol2qm74 1791 28 of of IN cord-015021-pol2qm74 1791 29 leucocyte leucocyte NNP cord-015021-pol2qm74 1791 30 migration migration NN cord-015021-pol2qm74 1791 31 inhibition inhibition NN cord-015021-pol2qm74 1791 32 . . . cord-015021-pol2qm74 1792 1 Migration migration NN cord-015021-pol2qm74 1792 2 of of IN cord-015021-pol2qm74 1792 3 their -PRON- PRP$ cord-015021-pol2qm74 1792 4 polymorphonuclear polymorphonuclear JJ cord-015021-pol2qm74 1792 5 leucocytes leucocytes NNP cord-015021-pol2qm74 1792 6 ( ( -LRB- cord-015021-pol2qm74 1792 7 PMNs PMNs NNP cord-015021-pol2qm74 1792 8 ) ) -RRB- cord-015021-pol2qm74 1792 9 was be VBD cord-015021-pol2qm74 1792 10 studied study VBN cord-015021-pol2qm74 1792 11 with with IN cord-015021-pol2qm74 1792 12 stimulation stimulation NN cord-015021-pol2qm74 1792 13 with with IN cord-015021-pol2qm74 1792 14 human human JJ cord-015021-pol2qm74 1792 15 recombinant recombinant JJ cord-015021-pol2qm74 1792 16 TNF TNF NNP cord-015021-pol2qm74 1792 17 in in IN cord-015021-pol2qm74 1792 18 concentration concentration NN cord-015021-pol2qm74 1792 19 of of IN cord-015021-pol2qm74 1792 20 166.7 166.7 CD cord-015021-pol2qm74 1792 21 U U NNP cord-015021-pol2qm74 1792 22 / / SYM cord-015021-pol2qm74 1792 23 ml ml NN cord-015021-pol2qm74 1792 24 ( ( -LRB- cord-015021-pol2qm74 1792 25 recommended recommend VBN cord-015021-pol2qm74 1792 26 by by IN cord-015021-pol2qm74 1792 27 manufacturer manufacturer NN cord-015021-pol2qm74 1792 28 is be VBZ cord-015021-pol2qm74 1792 29 the the DT cord-015021-pol2qm74 1792 30 range range NN cord-015021-pol2qm74 1792 31 of of IN cord-015021-pol2qm74 1792 32 10 10 CD cord-015021-pol2qm74 1792 33 - - SYM cord-015021-pol2qm74 1792 34 200 200 CD cord-015021-pol2qm74 1792 35 O o NN cord-015021-pol2qm74 1792 36 / / SYM cord-015021-pol2qm74 1792 37 ml ml NN cord-015021-pol2qm74 1792 38 ) ) -RRB- cord-015021-pol2qm74 1792 39 and and CC cord-015021-pol2qm74 1792 40 without without IN cord-015021-pol2qm74 1792 41 such such JJ cord-015021-pol2qm74 1792 42 . . . cord-015021-pol2qm74 1793 1 Ten ten CD cord-015021-pol2qm74 1793 2 healthy healthy JJ cord-015021-pol2qm74 1793 3 blood blood NN cord-015021-pol2qm74 1793 4 donors donor NNS cord-015021-pol2qm74 1793 5 formed form VBD cord-015021-pol2qm74 1793 6 control control NN cord-015021-pol2qm74 1793 7 group group NN cord-015021-pol2qm74 1793 8 . . . cord-015021-pol2qm74 1794 1 The the DT cord-015021-pol2qm74 1794 2 results result NNS cord-015021-pol2qm74 1794 3 obtained obtain VBN cord-015021-pol2qm74 1794 4 showed show VBD cord-015021-pol2qm74 1794 5 diminished diminish VBN cord-015021-pol2qm74 1794 6 PMN PMN NNP cord-015021-pol2qm74 1794 7 reactivity reactivity NN cord-015021-pol2qm74 1794 8 to to IN cord-015021-pol2qm74 1794 9 TNF TNF NNP cord-015021-pol2qm74 1794 10 in in IN cord-015021-pol2qm74 1794 11 patients patient NNS cord-015021-pol2qm74 1794 12 ( ( -LRB- cord-015021-pol2qm74 1794 13 migration migration NN cord-015021-pol2qm74 1794 14 inhibition inhibition NN cord-015021-pol2qm74 1794 15 was be VBD cord-015021-pol2qm74 1794 16 absent absent JJ cord-015021-pol2qm74 1794 17 ) ) -RRB- cord-015021-pol2qm74 1794 18 oscaring oscare VBG cord-015021-pol2qm74 1794 19 with with IN cord-015021-pol2qm74 1794 20 significantly significantly RB cord-015021-pol2qm74 1794 21 increased increase VBN cord-015021-pol2qm74 1794 22 migration migration NN cord-015021-pol2qm74 1794 23 ability ability NN cord-015021-pol2qm74 1794 24 of of IN cord-015021-pol2qm74 1794 25 their -PRON- PRP$ cord-015021-pol2qm74 1794 26 PMNs pmn NNS cord-015021-pol2qm74 1794 27 ( ( -LRB- cord-015021-pol2qm74 1794 28 107.2 107.2 CD cord-015021-pol2qm74 1794 29 % % NN cord-015021-pol2qm74 1794 30 of of IN cord-015021-pol2qm74 1794 31 that that DT cord-015021-pol2qm74 1794 32 in in IN cord-015021-pol2qm74 1794 33 control control NN cord-015021-pol2qm74 1794 34 group group NN cord-015021-pol2qm74 1794 35 ) ) -RRB- cord-015021-pol2qm74 1794 36 . . . cord-015021-pol2qm74 1795 1 At at IN cord-015021-pol2qm74 1795 2 the the DT cord-015021-pol2qm74 1795 3 same same JJ cord-015021-pol2qm74 1795 4 time time NN cord-015021-pol2qm74 1795 5 normal normal JJ cord-015021-pol2qm74 1795 6 PMNs pmn NNS cord-015021-pol2qm74 1795 7 in in IN cord-015021-pol2qm74 1795 8 control control NN cord-015021-pol2qm74 1795 9 group group NN cord-015021-pol2qm74 1795 10 did do VBD cord-015021-pol2qm74 1795 11 show show VB cord-015021-pol2qm74 1795 12 migration migration NN cord-015021-pol2qm74 1795 13 changes change NNS cord-015021-pol2qm74 1795 14 upon upon IN cord-015021-pol2qm74 1795 15 TNF TNF NNP cord-015021-pol2qm74 1795 16 stimulation stimulation NN cord-015021-pol2qm74 1795 17 . . . cord-015021-pol2qm74 1796 1 Considering consider VBG cord-015021-pol2qm74 1796 2 all all PDT cord-015021-pol2qm74 1796 3 the the DT cord-015021-pol2qm74 1796 4 above above IN cord-015021-pol2qm74 1796 5 we -PRON- PRP cord-015021-pol2qm74 1796 6 come come VBP cord-015021-pol2qm74 1796 7 to to IN cord-015021-pol2qm74 1796 8 a a DT cord-015021-pol2qm74 1796 9 conclusion conclusion NN cord-015021-pol2qm74 1796 10 that that IN cord-015021-pol2qm74 1796 11 externally externally RB cord-015021-pol2qm74 1796 12 added add VBD cord-015021-pol2qm74 1796 13 TNF TNF NNP cord-015021-pol2qm74 1796 14 fails fail VBZ cord-015021-pol2qm74 1796 15 to to TO cord-015021-pol2qm74 1796 16 activate activate VB cord-015021-pol2qm74 1796 17 PMNs pmn NNS cord-015021-pol2qm74 1796 18 in in IN cord-015021-pol2qm74 1796 19 critically critically RB cord-015021-pol2qm74 1796 20 ill ill JJ cord-015021-pol2qm74 1796 21 patients patient NNS cord-015021-pol2qm74 1796 22 more more RBR cord-015021-pol2qm74 1796 23 than than IN cord-015021-pol2qm74 1796 24 they -PRON- PRP cord-015021-pol2qm74 1796 25 are be VBP cord-015021-pol2qm74 1796 26 by by IN cord-015021-pol2qm74 1796 27 their -PRON- PRP$ cord-015021-pol2qm74 1796 28 endogenous endogenous JJ cord-015021-pol2qm74 1796 29 TNF TNF NNP cord-015021-pol2qm74 1796 30 . . . cord-015021-pol2qm74 1797 1 Moreover moreover RB cord-015021-pol2qm74 1797 2 , , , cord-015021-pol2qm74 1797 3 this this DT cord-015021-pol2qm74 1797 4 TNF tnf NN cord-015021-pol2qm74 1797 5 no no RB cord-015021-pol2qm74 1797 6 longer long RBR cord-015021-pol2qm74 1797 7 serves serve VBZ cord-015021-pol2qm74 1797 8 a a DT cord-015021-pol2qm74 1797 9 positive positive JJ cord-015021-pol2qm74 1797 10 chemotactic chemotactic JJ cord-015021-pol2qm74 1797 11 factor factor NN cord-015021-pol2qm74 1797 12 for for IN cord-015021-pol2qm74 1797 13 such such JJ cord-015021-pol2qm74 1797 14 PMNs pmn NNS cord-015021-pol2qm74 1797 15 . . . cord-015021-pol2qm74 1798 1 These these DT cord-015021-pol2qm74 1798 2 findings finding NNS cord-015021-pol2qm74 1798 3 may may MD cord-015021-pol2qm74 1798 4 suggest suggest VB cord-015021-pol2qm74 1798 5 that that IN cord-015021-pol2qm74 1798 6 in in IN cord-015021-pol2qm74 1798 7 critically critically RB cord-015021-pol2qm74 1798 8 ill ill JJ cord-015021-pol2qm74 1798 9 septic septic JJ cord-015021-pol2qm74 1798 10 patients patient NNS cord-015021-pol2qm74 1798 11 reactivity reactivity NN cord-015021-pol2qm74 1798 12 of of IN cord-015021-pol2qm74 1798 13 PMNs pmn NNS cord-015021-pol2qm74 1798 14 to to IN cord-015021-pol2qm74 1798 15 TNF TNF NNP cord-015021-pol2qm74 1798 16 is be VBZ cord-015021-pol2qm74 1798 17 deeply deeply RB cord-015021-pol2qm74 1798 18 altered alter VBN cord-015021-pol2qm74 1798 19 . . . cord-015021-pol2qm74 1799 1 TNF TNF NNP cord-015021-pol2qm74 1799 2 receptors receptor NNS cord-015021-pol2qm74 1799 3 of of IN cord-015021-pol2qm74 1799 4 PMNs pmn NNS cord-015021-pol2qm74 1799 5 are be VBP cord-015021-pol2qm74 1799 6 either either RB cord-015021-pol2qm74 1799 7 exhausted exhaust VBN cord-015021-pol2qm74 1799 8 as as IN cord-015021-pol2qm74 1799 9 such such JJ cord-015021-pol2qm74 1799 10 by by IN cord-015021-pol2qm74 1799 11 excessive excessive JJ cord-015021-pol2qm74 1799 12 stimulation stimulation NN cord-015021-pol2qm74 1799 13 with with IN cord-015021-pol2qm74 1799 14 endogenous endogenous JJ cord-015021-pol2qm74 1799 15 TNF TNF NNP cord-015021-pol2qm74 1799 16 or or CC cord-015021-pol2qm74 1799 17 further further JJ cord-015021-pol2qm74 1799 18 transmission transmission NN cord-015021-pol2qm74 1799 19 of of IN cord-015021-pol2qm74 1799 20 their -PRON- PRP$ cord-015021-pol2qm74 1799 21 message message NN cord-015021-pol2qm74 1799 22 is be VBZ cord-015021-pol2qm74 1799 23 impossible impossible JJ cord-015021-pol2qm74 1799 24 due due IN cord-015021-pol2qm74 1799 25 to to IN cord-015021-pol2qm74 1799 26 " " `` cord-015021-pol2qm74 1799 27 fatigue fatigue NN cord-015021-pol2qm74 1799 28 " " '' cord-015021-pol2qm74 1799 29 of of IN cord-015021-pol2qm74 1799 30 the the DT cord-015021-pol2qm74 1799 31 cell cell NN cord-015021-pol2qm74 1799 32 's 's POS cord-015021-pol2qm74 1799 33 activation activation NN cord-015021-pol2qm74 1799 34 mechanisms mechanism NNS cord-015021-pol2qm74 1799 35 . . . cord-015021-pol2qm74 1800 1 We -PRON- PRP cord-015021-pol2qm74 1800 2 express express VBP cord-015021-pol2qm74 1800 3 our -PRON- PRP$ cord-015021-pol2qm74 1800 4 gratitude gratitude NN cord-015021-pol2qm74 1800 5 to to IN cord-015021-pol2qm74 1800 6 REANAL REANAL NNP cord-015021-pol2qm74 1800 7 Factory Factory NNP cord-015021-pol2qm74 1800 8 of of IN cord-015021-pol2qm74 1800 9 Laboratory Laboratory NNP cord-015021-pol2qm74 1800 10 Chemicals Chemicals NNPS cord-015021-pol2qm74 1800 11 for for IN cord-015021-pol2qm74 1800 12 generously generously RB cord-015021-pol2qm74 1800 13 providing provide VBG cord-015021-pol2qm74 1800 14 us -PRON- PRP cord-015021-pol2qm74 1800 15 with with IN cord-015021-pol2qm74 1800 16 a a DT cord-015021-pol2qm74 1800 17 TNF tnf NN cord-015021-pol2qm74 1800 18 com com NN cord-015021-pol2qm74 1800 19 ~ ~ NFP cord-015021-pol2qm74 1800 20 rcial rcial JJ cord-015021-pol2qm74 1800 21 sample sample NN cord-015021-pol2qm74 1800 22 . . . cord-015021-pol2qm74 1801 1 ~-SANGUIS ~-SANGUIS NFP cord-015021-pol2qm74 1801 2 Medical medical JJ cord-015021-pol2qm74 1801 3 , , , cord-015021-pol2qm74 1801 4 Ekaterineburg Ekaterineburg NNP cord-015021-pol2qm74 1801 5 Russia Russia NNP cord-015021-pol2qm74 1801 6 ; ; : cord-015021-pol2qm74 1801 7 S S NNP cord-015021-pol2qm74 1801 8 - - HYPH cord-015021-pol2qm74 1801 9 Urals Urals NNP cord-015021-pol2qm74 1801 10 Med.lnst Med.lnst NNP cord-015021-pol2qm74 1801 11 . . . cord-015021-pol2qm74 1802 1 Activated activate VBN cord-015021-pol2qm74 1802 2 neutrophils neutrophil NNS cord-015021-pol2qm74 1802 3 infiltrating infiltrate VBG cord-015021-pol2qm74 1802 4 the the DT cord-015021-pol2qm74 1802 5 local local JJ cord-015021-pol2qm74 1802 6 site site NN cord-015021-pol2qm74 1802 7 of of IN cord-015021-pol2qm74 1802 8 inflammation inflammation NN cord-015021-pol2qm74 1802 9 following follow VBG cord-015021-pol2qm74 1802 10 trauma trauma NN cord-015021-pol2qm74 1802 11 release release VBP cord-015021-pol2qm74 1802 12 high high JJ cord-015021-pol2qm74 1802 13 amounts amount NNS cord-015021-pol2qm74 1802 14 of of IN cord-015021-pol2qm74 1802 15 destructive destructive JJ cord-015021-pol2qm74 1802 16 lysosomal lysosomal JJ cord-015021-pol2qm74 1802 17 enzymes enzyme NNS cord-015021-pol2qm74 1802 18 into into IN cord-015021-pol2qm74 1802 19 the the DT cord-015021-pol2qm74 1802 20 extracellular extracellular JJ cord-015021-pol2qm74 1802 21 space space NN cord-015021-pol2qm74 1802 22 . . . cord-015021-pol2qm74 1803 1 Cytokines cytokine NNS cord-015021-pol2qm74 1803 2 were be VBD cord-015021-pol2qm74 1803 3 discussed discuss VBN cord-015021-pol2qm74 1803 4 to to TO cord-015021-pol2qm74 1803 5 be be VB cord-015021-pol2qm74 1803 6 involved involve VBN cord-015021-pol2qm74 1803 7 in in IN cord-015021-pol2qm74 1803 8 regulation regulation NN cord-015021-pol2qm74 1803 9 of of IN cord-015021-pol2qm74 1803 10 this this DT cord-015021-pol2qm74 1803 11 early early JJ cord-015021-pol2qm74 1803 12 process process NN cord-015021-pol2qm74 1803 13 . . . cord-015021-pol2qm74 1804 1 The the DT cord-015021-pol2qm74 1804 2 task task NN cord-015021-pol2qm74 1804 3 of of IN cord-015021-pol2qm74 1804 4 this this DT cord-015021-pol2qm74 1804 5 investigation investigation NN cord-015021-pol2qm74 1804 6 was be VBD cord-015021-pol2qm74 1804 7 to to TO cord-015021-pol2qm74 1804 8 evaluate evaluate VB cord-015021-pol2qm74 1804 9 the the DT cord-015021-pol2qm74 1804 10 possible possible JJ cord-015021-pol2qm74 1804 11 regulatory regulatory JJ cord-015021-pol2qm74 1804 12 role role NN cord-015021-pol2qm74 1804 13 of of IN cord-015021-pol2qm74 1804 14 interleukin-6 interleukin-6 NNP cord-015021-pol2qm74 1804 15 ( ( -LRB- cord-015021-pol2qm74 1804 16 IL-6 IL-6 NNP cord-015021-pol2qm74 1804 17 ) ) -RRB- cord-015021-pol2qm74 1804 18 and and CC cord-015021-pol2qm74 1804 19 its -PRON- PRP$ cord-015021-pol2qm74 1804 20 potential potential JJ cord-015021-pol2qm74 1804 21 immunosupressive immunosupressive JJ cord-015021-pol2qm74 1804 22 opponent opponent NN cord-015021-pol2qm74 1804 23 , , , cord-015021-pol2qm74 1804 24 the the DT cord-015021-pol2qm74 1804 25 transforming transform VBG cord-015021-pol2qm74 1804 26 growth growth NN cord-015021-pol2qm74 1804 27 factor- factor- NNP cord-015021-pol2qm74 1804 28 & & CC cord-015021-pol2qm74 1804 29 , , , cord-015021-pol2qm74 1804 30 in in IN cord-015021-pol2qm74 1804 31 regulation regulation NN cord-015021-pol2qm74 1804 32 of of IN cord-015021-pol2qm74 1804 33 neutrophil neutrophil NN cord-015021-pol2qm74 1804 34 degranulation degranulation NN cord-015021-pol2qm74 1804 35 . . . cord-015021-pol2qm74 1805 1 We -PRON- PRP cord-015021-pol2qm74 1805 2 analysed analyse VBD cord-015021-pol2qm74 1805 3 the the DT cord-015021-pol2qm74 1805 4 concentration concentration NN cord-015021-pol2qm74 1805 5 of of IN cord-015021-pol2qm74 1805 6 the the DT cord-015021-pol2qm74 1805 7 al al NNP cord-015021-pol2qm74 1805 8 - - HYPH cord-015021-pol2qm74 1805 9 proteinase proteinase NN cord-015021-pol2qm74 1805 10 - - HYPH cord-015021-pol2qm74 1805 11 inhibitor inhibitor NN cord-015021-pol2qm74 1805 12 complex complex NN cord-015021-pol2qm74 1805 13 of of IN cord-015021-pol2qm74 1805 14 the the DT cord-015021-pol2qm74 1805 15 lysosomal lysosomal JJ cord-015021-pol2qm74 1805 16 elastase elastase NN cord-015021-pol2qm74 1805 17 as as IN cord-015021-pol2qm74 1805 18 marker marker NN cord-015021-pol2qm74 1805 19 for for IN cord-015021-pol2qm74 1805 20 the the DT cord-015021-pol2qm74 1805 21 degranulation degranulation NN cord-015021-pol2qm74 1805 22 of of IN cord-015021-pol2qm74 1805 23 neutrophils neutrophil NNS cord-015021-pol2qm74 1805 24 as as RB cord-015021-pol2qm74 1805 25 well well RB cord-015021-pol2qm74 1805 26 as as IN cord-015021-pol2qm74 1805 27 the the DT cord-015021-pol2qm74 1805 28 levels level NNS cord-015021-pol2qm74 1805 29 of of IN cord-015021-pol2qm74 1805 30 IL-6 IL-6 NNP cord-015021-pol2qm74 1805 31 and and CC cord-015021-pol2qm74 1805 32 TGF-61 TGF-61 NNP cord-015021-pol2qm74 1805 33 in in IN cord-015021-pol2qm74 1805 34 the the DT cord-015021-pol2qm74 1805 35 plasma plasma NN cord-015021-pol2qm74 1805 36 probes probe NNS cord-015021-pol2qm74 1805 37 of of IN cord-015021-pol2qm74 1805 38 patients patient NNS cord-015021-pol2qm74 1805 39 undergoing undergo VBG cord-015021-pol2qm74 1805 40 multiple multiple JJ cord-015021-pol2qm74 1805 41 trauma trauma NN cord-015021-pol2qm74 1805 42 and and CC cord-015021-pol2qm74 1805 43 severe severe JJ cord-015021-pol2qm74 1805 44 surgeries surgery NNS cord-015021-pol2qm74 1805 45 . . . cord-015021-pol2qm74 1806 1 The the DT cord-015021-pol2qm74 1806 2 time time NN cord-015021-pol2qm74 1806 3 courses course NNS cord-015021-pol2qm74 1806 4 of of IN cord-015021-pol2qm74 1806 5 IL-6 IL-6 NNP cord-015021-pol2qm74 1806 6 and and CC cord-015021-pol2qm74 1806 7 elastase elastase NN cord-015021-pol2qm74 1806 8 were be VBD cord-015021-pol2qm74 1806 9 found find VBN cord-015021-pol2qm74 1806 10 to to TO cord-015021-pol2qm74 1806 11 be be VB cord-015021-pol2qm74 1806 12 highly highly RB cord-015021-pol2qm74 1806 13 correlated correlate VBN cord-015021-pol2qm74 1806 14 , , , cord-015021-pol2qm74 1806 15 wheras whera VBZ cord-015021-pol2qm74 1806 16 the the DT cord-015021-pol2qm74 1806 17 concentrations concentration NNS cord-015021-pol2qm74 1806 18 of of IN cord-015021-pol2qm74 1806 19 the the DT cord-015021-pol2qm74 1806 20 cytokine cytokine NN cord-015021-pol2qm74 1806 21 TGF TGF NNP cord-015021-pol2qm74 1806 22 - - HYPH cord-015021-pol2qm74 1806 23 E~ E~ NNS cord-015021-pol2qm74 1806 24 were be VBD cord-015021-pol2qm74 1806 25 found find VBN cord-015021-pol2qm74 1806 26 to to TO cord-015021-pol2qm74 1806 27 be be VB cord-015021-pol2qm74 1806 28 not not RB cord-015021-pol2qm74 1806 29 significantly significantly RB cord-015021-pol2qm74 1806 30 altered alter VBN cord-015021-pol2qm74 1806 31 in in IN cord-015021-pol2qm74 1806 32 comparison comparison NN cord-015021-pol2qm74 1806 33 to to IN cord-015021-pol2qm74 1806 34 the the DT cord-015021-pol2qm74 1806 35 control control NN cord-015021-pol2qm74 1806 36 group group NN cord-015021-pol2qm74 1806 37 . . . cord-015021-pol2qm74 1807 1 This this DT cord-015021-pol2qm74 1807 2 close close JJ cord-015021-pol2qm74 1807 3 temporal temporal JJ cord-015021-pol2qm74 1807 4 correlationship correlationship NN cord-015021-pol2qm74 1807 5 was be VBD cord-015021-pol2qm74 1807 6 confirmed confirm VBN cord-015021-pol2qm74 1807 7 by by IN cord-015021-pol2qm74 1807 8 investigation investigation NN cord-015021-pol2qm74 1807 9 of of IN cord-015021-pol2qm74 1807 10 fluids fluid NNS cord-015021-pol2qm74 1807 11 derived derive VBN cord-015021-pol2qm74 1807 12 from from IN cord-015021-pol2qm74 1807 13 sites site NNS cord-015021-pol2qm74 1807 14 of of IN cord-015021-pol2qm74 1807 15 inflammation inflammation NN cord-015021-pol2qm74 1807 16 . . . cord-015021-pol2qm74 1808 1 Interstingly interstingly RB cord-015021-pol2qm74 1808 2 , , , cord-015021-pol2qm74 1808 3 the the DT cord-015021-pol2qm74 1808 4 inhibitory inhibitory JJ cord-015021-pol2qm74 1808 5 potential potential NN cord-015021-pol2qm74 1808 6 ( ( -LRB- cord-015021-pol2qm74 1808 7 ~zcproteinase ~zcproteinase CD cord-015021-pol2qm74 1808 8 inhibitor inhibitor NN cord-015021-pol2qm74 1808 9 , , , cord-015021-pol2qm74 1808 10 antithrombin antithrombin NN cord-015021-pol2qm74 1808 11 III III NNP cord-015021-pol2qm74 1808 12 ) ) -RRB- cord-015021-pol2qm74 1808 13 was be VBD cord-015021-pol2qm74 1808 14 dramatically dramatically RB cord-015021-pol2qm74 1808 15 reduced reduce VBN cord-015021-pol2qm74 1808 16 in in IN cord-015021-pol2qm74 1808 17 the the DT cord-015021-pol2qm74 1808 18 early early JJ cord-015021-pol2qm74 1808 19 inflammatory inflammatory JJ cord-015021-pol2qm74 1808 20 phase phase NN cord-015021-pol2qm74 1808 21 . . . cord-015021-pol2qm74 1809 1 To to TO cord-015021-pol2qm74 1809 2 prove prove VB cord-015021-pol2qm74 1809 3 this this DT cord-015021-pol2qm74 1809 4 in in IN cord-015021-pol2qm74 1809 5 vivo vivo NN cord-015021-pol2qm74 1809 6 findings finding NNS cord-015021-pol2qm74 1809 7 , , , cord-015021-pol2qm74 1809 8 the the DT cord-015021-pol2qm74 1809 9 effects effect NNS cord-015021-pol2qm74 1809 10 of of IN cord-015021-pol2qm74 1809 11 IL-6 IL-6 NNP cord-015021-pol2qm74 1809 12 and and CC cord-015021-pol2qm74 1809 13 TGF TGF NNP cord-015021-pol2qm74 1809 14 - - HYPH cord-015021-pol2qm74 1809 15 I~ I~ NNP cord-015021-pol2qm74 1809 16 1 1 CD cord-015021-pol2qm74 1809 17 on on IN cord-015021-pol2qm74 1809 18 the the DT cord-015021-pol2qm74 1809 19 degranulation degranulation NN cord-015021-pol2qm74 1809 20 of of IN cord-015021-pol2qm74 1809 21 isolated isolate VBN cord-015021-pol2qm74 1809 22 human human JJ cord-015021-pol2qm74 1809 23 neutrophils neutrophil NNS cord-015021-pol2qm74 1809 24 of of IN cord-015021-pol2qm74 1809 25 healthy healthy JJ cord-015021-pol2qm74 1809 26 donors donor NNS cord-015021-pol2qm74 1809 27 was be VBD cord-015021-pol2qm74 1809 28 investigated investigate VBN cord-015021-pol2qm74 1809 29 in in IN cord-015021-pol2qm74 1809 30 vitro vitro FW cord-015021-pol2qm74 1809 31 . . . cord-015021-pol2qm74 1810 1 Pathological pathological JJ cord-015021-pol2qm74 1810 2 high high JJ cord-015021-pol2qm74 1810 3 concentrations concentration NNS cord-015021-pol2qm74 1810 4 of of IN cord-015021-pol2qm74 1810 5 rhlL-6 rhlL-6 VBG cord-015021-pol2qm74 1810 6 up up IN cord-015021-pol2qm74 1810 7 to to IN cord-015021-pol2qm74 1810 8 104U 104u CD cord-015021-pol2qm74 1811 1 /ml /ml . cord-015021-pol2qm74 1811 2 ( ( -LRB- cord-015021-pol2qm74 1812 1 as as IN cord-015021-pol2qm74 1812 2 detected detect VBN cord-015021-pol2qm74 1812 3 in in IN cord-015021-pol2qm74 1812 4 fluids fluid NNS cord-015021-pol2qm74 1812 5 derived derive VBN cord-015021-pol2qm74 1812 6 from from IN cord-015021-pol2qm74 1812 7 local local JJ cord-015021-pol2qm74 1812 8 inflammatory inflammatory JJ cord-015021-pol2qm74 1812 9 site site NN cord-015021-pol2qm74 1812 10 ) ) -RRB- cord-015021-pol2qm74 1812 11 were be VBD cord-015021-pol2qm74 1812 12 found find VBN cord-015021-pol2qm74 1812 13 to to TO cord-015021-pol2qm74 1812 14 be be VB cord-015021-pol2qm74 1812 15 capable capable JJ cord-015021-pol2qm74 1812 16 to to TO cord-015021-pol2qm74 1812 17 induce induce VB cord-015021-pol2qm74 1812 18 a a DT cord-015021-pol2qm74 1812 19 significant significant JJ cord-015021-pol2qm74 1812 20 release release NN cord-015021-pol2qm74 1812 21 of of IN cord-015021-pol2qm74 1812 22 lysosomal lysosomal JJ cord-015021-pol2qm74 1812 23 elastase elastase NN cord-015021-pol2qm74 1812 24 in in IN cord-015021-pol2qm74 1812 25 a a DT cord-015021-pol2qm74 1812 26 concentration concentration NN cord-015021-pol2qm74 1812 27 - - HYPH cord-015021-pol2qm74 1812 28 dependent dependent JJ cord-015021-pol2qm74 1812 29 manner manner NN cord-015021-pol2qm74 1812 30 , , , cord-015021-pol2qm74 1812 31 whereas whereas IN cord-015021-pol2qm74 1812 32 the the DT cord-015021-pol2qm74 1812 33 degranulation degranulation NN cord-015021-pol2qm74 1812 34 of of IN cord-015021-pol2qm74 1812 35 neutrophils neutrophil NNS cord-015021-pol2qm74 1812 36 was be VBD cord-015021-pol2qm74 1812 37 uneffected uneffecte VBN cord-015021-pol2qm74 1812 38 by by IN cord-015021-pol2qm74 1812 39 TGF-61 TGF-61 NNP cord-015021-pol2qm74 1812 40 . . . cord-015021-pol2qm74 1813 1 In in IN cord-015021-pol2qm74 1813 2 conclusion conclusion NN cord-015021-pol2qm74 1813 3 , , , cord-015021-pol2qm74 1813 4 these these DT cord-015021-pol2qm74 1813 5 data datum NNS cord-015021-pol2qm74 1813 6 suggest suggest VBP cord-015021-pol2qm74 1813 7 a a DT cord-015021-pol2qm74 1813 8 contribution contribution NN cord-015021-pol2qm74 1813 9 of of IN cord-015021-pol2qm74 1813 10 IL-6 IL-6 NNP cord-015021-pol2qm74 1813 11 in in IN cord-015021-pol2qm74 1813 12 regulation regulation NN cord-015021-pol2qm74 1813 13 of of IN cord-015021-pol2qm74 1813 14 neutrophil neutrophil NN cord-015021-pol2qm74 1813 15 activation activation NN cord-015021-pol2qm74 1813 16 at at IN cord-015021-pol2qm74 1813 17 sides side NNS cord-015021-pol2qm74 1813 18 of of IN cord-015021-pol2qm74 1813 19 inflammation inflammation NN cord-015021-pol2qm74 1813 20 . . . cord-015021-pol2qm74 1814 1 The the DT cord-015021-pol2qm74 1814 2 immunosuppressive immunosuppressive JJ cord-015021-pol2qm74 1814 3 cytokine cytokine NN cord-015021-pol2qm74 1814 4 TGF TGF NNP cord-015021-pol2qm74 1814 5 - - HYPH cord-015021-pol2qm74 1814 6 I&~ I&~ NNP cord-015021-pol2qm74 1814 7 seems seem VBZ cord-015021-pol2qm74 1814 8 to to TO cord-015021-pol2qm74 1814 9 have have VB cord-015021-pol2qm74 1814 10 no no DT cord-015021-pol2qm74 1814 11 direct direct JJ cord-015021-pol2qm74 1814 12 regulatory regulatory JJ cord-015021-pol2qm74 1814 13 effect effect NN cord-015021-pol2qm74 1814 14 beside beside IN cord-015021-pol2qm74 1814 15 its -PRON- PRP$ cord-015021-pol2qm74 1814 16 described described JJ cord-015021-pol2qm74 1814 17 chemotactic chemotactic JJ cord-015021-pol2qm74 1814 18 function function NN cord-015021-pol2qm74 1814 19 on on IN cord-015021-pol2qm74 1814 20 neutrephils neutrephils NNP cord-015021-pol2qm74 1814 21 . . . cord-015021-pol2qm74 1815 1 Postirradiation Postirradiation NNP cord-015021-pol2qm74 1815 2 chan chan NNP cord-015021-pol2qm74 1815 3 ~ ~ NFP cord-015021-pol2qm74 1815 4 es es NNP cord-015021-pol2qm74 1815 5 of of IN cord-015021-pol2qm74 1815 6 adhesive adhesive JJ cord-015021-pol2qm74 1815 7 properties property NNS cord-015021-pol2qm74 1815 8 arid arid JJ cord-015021-pol2qm74 1815 9 supercoiled supercoile VBN cord-015021-pol2qm74 1815 10 nucleoid nucleoid NNP cord-015021-pol2qm74 1815 11 DNA DNA NNP cord-015021-pol2qm74 1815 12 structure structure NN cord-015021-pol2qm74 1815 13 of of IN cord-015021-pol2qm74 1815 14 blood blood NN cord-015021-pol2qm74 1815 15 leukocytes leukocyte NNS cord-015021-pol2qm74 1815 16 were be VBD cord-015021-pol2qm74 1815 17 studied study VBN cord-015021-pol2qm74 1815 18 in in IN cord-015021-pol2qm74 1815 19 Macaca Macaca NNP cord-015021-pol2qm74 1815 20 nemestrina nemestrina NNP cord-015021-pol2qm74 1815 21 andrats andrat NNS cord-015021-pol2qm74 1815 22 . . . cord-015021-pol2qm74 1816 1 The the DT cord-015021-pol2qm74 1816 2 dynamics dynamic NNS cord-015021-pol2qm74 1816 3 of of IN cord-015021-pol2qm74 1816 4 membrane membrane NN cord-015021-pol2qm74 1816 5 chan chan NNP cord-015021-pol2qm74 1816 6 ~ ~ NFP cord-015021-pol2qm74 1816 7 es es XX cord-015021-pol2qm74 1816 8 after after IN cord-015021-pol2qm74 1816 9 nonlethal nonlethal JJ cord-015021-pol2qm74 1816 10 irradiation irradiation NN cord-015021-pol2qm74 1816 11 of of IN cord-015021-pol2qm74 1816 12 rats rat NNS cord-015021-pol2qm74 1816 13 demonstrated demonstrate VBD cord-015021-pol2qm74 1816 14 the the DT cord-015021-pol2qm74 1816 15 temporary temporary JJ cord-015021-pol2qm74 1816 16 increase increase NN cord-015021-pol2qm74 1816 17 of of IN cord-015021-pol2qm74 1816 18 the the DT cord-015021-pol2qm74 1816 19 leukocyte leukocyte NN cord-015021-pol2qm74 1816 20 adherence adherence NN cord-015021-pol2qm74 1816 21 at at IN cord-015021-pol2qm74 1816 22 24 24 CD cord-015021-pol2qm74 1816 23 h h NN cord-015021-pol2qm74 1816 24 followed follow VBN cord-015021-pol2qm74 1816 25 by by IN cord-015021-pol2qm74 1816 26 return return NN cord-015021-pol2qm74 1816 27 of of IN cord-015021-pol2qm74 1816 28 this this DT cord-015021-pol2qm74 1816 29 parameter parameter NN cord-015021-pol2qm74 1816 30 to to IN cord-015021-pol2qm74 1816 31 normal normal JJ cord-015021-pol2qm74 1816 32 levels level NNS cord-015021-pol2qm74 1816 33 at at IN cord-015021-pol2qm74 1816 34 48 48 CD cord-015021-pol2qm74 1816 35 h. h. NN cord-015021-pol2qm74 1817 1 After after IN cord-015021-pol2qm74 1817 2 lethal lethal JJ cord-015021-pol2qm74 1817 3 irradiation irradiation NN cord-015021-pol2qm74 1817 4 of of IN cord-015021-pol2qm74 1817 5 both both DT cord-015021-pol2qm74 1817 6 animal animal NN cord-015021-pol2qm74 1817 7 species species VBP cord-015021-pol2qm74 1817 8 the the DT cord-015021-pol2qm74 1817 9 increase increase NN cord-015021-pol2qm74 1817 10 in in IN cord-015021-pol2qm74 1817 11 adhesive adhesive JJ cord-015021-pol2qm74 1817 12 leukooytes leukooytes NNP cord-015021-pol2qm74 1817 13 fraction fraction NN cord-015021-pol2qm74 1817 14 was be VBD cord-015021-pol2qm74 1817 15 detected detect VBN cord-015021-pol2qm74 1817 16 as as RB cord-015021-pol2qm74 1817 17 early early RB cord-015021-pol2qm74 1817 18 as as IN cord-015021-pol2qm74 1817 19 at at IN cord-015021-pol2qm74 1817 20 3 3 CD cord-015021-pol2qm74 1817 21 h. h. NN cord-015021-pol2qm74 1818 1 This this DT cord-015021-pol2qm74 1819 1 hi hi UH cord-015021-pol2qm74 1820 1 ~her ~her NNP cord-015021-pol2qm74 1820 2 index index NN cord-015021-pol2qm74 1820 3 persisted persist VBD cord-015021-pol2qm74 1820 4 until until IN cord-015021-pol2qm74 1820 5 the the DT cord-015021-pol2qm74 1820 6 end end NN cord-015021-pol2qm74 1820 7 of of IN cord-015021-pol2qm74 1820 8 experiments experiment NNS cord-015021-pol2qm74 1820 9 ( ( -LRB- cord-015021-pol2qm74 1820 10 5 5 CD cord-015021-pol2qm74 1820 11 days day NNS cord-015021-pol2qm74 1820 12 ) ) -RRB- cord-015021-pol2qm74 1820 13 . . . cord-015021-pol2qm74 1821 1 The the DT cord-015021-pol2qm74 1821 2 early early JJ cord-015021-pol2qm74 1821 3 ( ( -LRB- cord-015021-pol2qm74 1821 4 3 3 CD cord-015021-pol2qm74 1821 5 - - HYPH cord-015021-pol2qm74 1821 6 5h 5h LS cord-015021-pol2qm74 1821 7 ) ) -RRB- cord-015021-pol2qm74 1821 8 temporary temporary JJ cord-015021-pol2qm74 1821 9 loosin~ loosin~ NNP cord-015021-pol2qm74 1821 10 of of IN cord-015021-pol2qm74 1821 11 supercoiled supercoiled JJ cord-015021-pol2qm74 1821 12 DNA dna NN cord-015021-pol2qm74 1821 13 structure structure NN cord-015021-pol2qm74 1821 14 was be VBD cord-015021-pol2qm74 1821 15 demonstrated demonstrate VBN cord-015021-pol2qm74 1821 16 in in IN cord-015021-pol2qm74 1821 17 the the DT cord-015021-pol2qm74 1821 18 leukocytes leukocyte NNS cord-015021-pol2qm74 1821 19 of of IN cord-015021-pol2qm74 1821 20 nonlethally nonlethally RB cord-015021-pol2qm74 1821 21 irradiated irradiate VBN cord-015021-pol2qm74 1821 22 animals animal NNS cord-015021-pol2qm74 1821 23 . . . cord-015021-pol2qm74 1822 1 This this DT cord-015021-pol2qm74 1822 2 phenomenon phenomenon NN cord-015021-pol2qm74 1822 3 seems seem VBZ cord-015021-pol2qm74 1822 4 to to TO cord-015021-pol2qm74 1822 5 be be VB cord-015021-pol2qm74 1822 6 connected connect VBN cord-015021-pol2qm74 1822 7 with with IN cord-015021-pol2qm74 1822 8 the the DT cord-015021-pol2qm74 1822 9 lymphocyte lymphocyte NN cord-015021-pol2qm74 1822 10 fraction fraction NN cord-015021-pol2qm74 1822 11 chan~ chan~ NNP cord-015021-pol2qm74 1823 1 es es NNP cord-015021-pol2qm74 1823 2 . . . cord-015021-pol2qm74 1824 1 This this DT cord-015021-pol2qm74 1824 2 process process NN cord-015021-pol2qm74 1824 3 was be VBD cord-015021-pol2qm74 1824 4 not not RB cord-015021-pol2qm74 1824 5 dependent dependent JJ cord-015021-pol2qm74 1824 6 on on IN cord-015021-pol2qm74 1824 7 altered altered JJ cord-015021-pol2qm74 1824 8 adhesive adhesive JJ cord-015021-pol2qm74 1824 9 properties property NNS cord-015021-pol2qm74 1824 10 of of IN cord-015021-pol2qm74 1824 11 leukocyte leukocyte NN cord-015021-pol2qm74 1824 12 membranes membrane NNS cord-015021-pol2qm74 1824 13 . . . cord-015021-pol2qm74 1825 1 The the DT cord-015021-pol2qm74 1825 2 membrane membrane NN cord-015021-pol2qm74 1825 3 chan chan NNP cord-015021-pol2qm74 1825 4 ~ ~ NFP cord-015021-pol2qm74 1825 5 es es XX cord-015021-pol2qm74 1825 6 of of IN cord-015021-pol2qm74 1825 7 leukocytes leukocyte NNS cord-015021-pol2qm74 1825 8 preceded precede VBD cord-015021-pol2qm74 1825 9 decondensation decondensation NN cord-015021-pol2qm74 1825 10 of of IN cord-015021-pol2qm74 1825 11 supercoiled supercoiled JJ cord-015021-pol2qm74 1825 12 DNA dna NN cord-015021-pol2qm74 1825 13 after after IN cord-015021-pol2qm74 1825 14 lethal lethal JJ cord-015021-pol2qm74 1825 15 irradiation irradiation NN cord-015021-pol2qm74 1825 16 of of IN cord-015021-pol2qm74 1825 17 animals animal NNS cord-015021-pol2qm74 1825 18 , , . cord-015021-pol2qm74 1826 1 In in IN cord-015021-pol2qm74 1826 2 this this DT cord-015021-pol2qm74 1826 3 case case NN cord-015021-pol2qm74 1826 4 loosin~ loosin~ NNP cord-015021-pol2qm74 1826 5 of of IN cord-015021-pol2qm74 1826 6 supercoiled supercoiled JJ cord-015021-pol2qm74 1826 7 DNA DNA NNP cord-015021-pol2qm74 1826 8 pro-~ressively pro-~ressively NN cord-015021-pol2qm74 1826 9 increased increase VBD cord-015021-pol2qm74 1826 10 at at IN cord-015021-pol2qm74 1826 11 24 24 CD cord-015021-pol2qm74 1826 12 h h NN cord-015021-pol2qm74 1826 13 and and CC cord-015021-pol2qm74 1826 14 at at IN cord-015021-pol2qm74 1826 15 the the DT cord-015021-pol2qm74 1826 16 later later JJ cord-015021-pol2qm74 1826 17 terms term NNS cord-015021-pol2qm74 1826 18 of of IN cord-015021-pol2qm74 1826 19 postirradiation postirradiation NN cord-015021-pol2qm74 1826 20 period period NN cord-015021-pol2qm74 1826 21 . . . cord-015021-pol2qm74 1827 1 The the DT cord-015021-pol2qm74 1827 2 systemic systemic JJ cord-015021-pol2qm74 1827 3 inflammatory inflammatory JJ cord-015021-pol2qm74 1827 4 response response NN cord-015021-pol2qm74 1827 5 syndrome syndrome NN cord-015021-pol2qm74 1827 6 ( ( -LRB- cord-015021-pol2qm74 1827 7 SIRS SIRS NNP cord-015021-pol2qm74 1827 8 ) ) -RRB- cord-015021-pol2qm74 1827 9 involves involve VBZ cord-015021-pol2qm74 1827 10 many many JJ cord-015021-pol2qm74 1827 11 inanunological inanunological JJ cord-015021-pol2qm74 1827 12 reactions reaction NNS cord-015021-pol2qm74 1827 13 of of IN cord-015021-pol2qm74 1827 14 the the DT cord-015021-pol2qm74 1827 15 host host NN cord-015021-pol2qm74 1827 16 including include VBG cord-015021-pol2qm74 1827 17 acfivatinn acfivatinn NNP cord-015021-pol2qm74 1827 18 of of IN cord-015021-pol2qm74 1827 19 inflammatory inflammatory JJ cord-015021-pol2qm74 1827 20 mediator mediator NN cord-015021-pol2qm74 1827 21 cascades cascade NNS cord-015021-pol2qm74 1827 22 and and CC cord-015021-pol2qm74 1827 23 depression depression NN cord-015021-pol2qm74 1827 24 of of IN cord-015021-pol2qm74 1827 25 cellular cellular JJ cord-015021-pol2qm74 1827 26 reactivity reactivity NN cord-015021-pol2qm74 1827 27 in in IN cord-015021-pol2qm74 1827 28 T T NNP cord-015021-pol2qm74 1827 29 - - HYPH cord-015021-pol2qm74 1827 30 lymphecytes lymphecytes NNPS cord-015021-pol2qm74 1827 31 ( ( -LRB- cord-015021-pol2qm74 1827 32 1 1 CD cord-015021-pol2qm74 1827 33 ) ) -RRB- cord-015021-pol2qm74 1827 34 . . . cord-015021-pol2qm74 1828 1 There there EX cord-015021-pol2qm74 1828 2 are be VBP cord-015021-pol2qm74 1828 3 reports report NNS cord-015021-pol2qm74 1828 4 of of IN cord-015021-pol2qm74 1828 5 nentrophil nentrophil JJ cord-015021-pol2qm74 1828 6 dysfunction dysfunction NN cord-015021-pol2qm74 1828 7 in in IN cord-015021-pol2qm74 1828 8 inflammatory inflammatory JJ cord-015021-pol2qm74 1828 9 disorders disorder NNS cord-015021-pol2qm74 1828 10 of of IN cord-015021-pol2qm74 1828 11 the the DT cord-015021-pol2qm74 1828 12 skin skin NN cord-015021-pol2qm74 1828 13 ( ( -LRB- cord-015021-pol2qm74 1828 14 2 2 CD cord-015021-pol2qm74 1828 15 ) ) -RRB- cord-015021-pol2qm74 1828 16 , , , cord-015021-pol2qm74 1828 17 Are be VBP cord-015021-pol2qm74 1828 18 there there EX cord-015021-pol2qm74 1828 19 dysfunctions dysfunction NNS cord-015021-pol2qm74 1828 20 concerning concern VBG cord-015021-pol2qm74 1828 21 the the DT cord-015021-pol2qm74 1828 22 unspecific unspecific JJ cord-015021-pol2qm74 1828 23 host host NN cord-015021-pol2qm74 1828 24 defense defense NN cord-015021-pol2qm74 1828 25 in in IN cord-015021-pol2qm74 1828 26 SIRS SIRS NNP cord-015021-pol2qm74 1828 27 , , , cord-015021-pol2qm74 1828 28 as as RB cord-015021-pol2qm74 1828 29 well well RB cord-015021-pol2qm74 1828 30 ? ? . cord-015021-pol2qm74 1829 1 In in IN cord-015021-pol2qm74 1829 2 this this DT cord-015021-pol2qm74 1829 3 study study NN cord-015021-pol2qm74 1829 4 , , , cord-015021-pol2qm74 1829 5 we -PRON- PRP cord-015021-pol2qm74 1829 6 examined examine VBD cord-015021-pol2qm74 1829 7 the the DT cord-015021-pol2qm74 1829 8 reactivity reactivity NN cord-015021-pol2qm74 1829 9 of of IN cord-015021-pol2qm74 1829 10 neutrophil neutrophil NN cord-015021-pol2qm74 1829 11 granolocytes granolocyte NNS cord-015021-pol2qm74 1829 12 from from IN cord-015021-pol2qm74 1829 13 patients patient NNS cord-015021-pol2qm74 1829 14 suffering suffer VBG cord-015021-pol2qm74 1829 15 from from IN cord-015021-pol2qm74 1829 16 SIRS SIRS NNP cord-015021-pol2qm74 1829 17 . . . cord-015021-pol2qm74 1830 1 Twenty twenty CD cord-015021-pol2qm74 1830 2 - - HYPH cord-015021-pol2qm74 1830 3 one one CD cord-015021-pol2qm74 1830 4 patients patient NNS cord-015021-pol2qm74 1830 5 ( ( -LRB- cord-015021-pol2qm74 1830 6 APACHE APACHE NNP cord-015021-pol2qm74 1830 7 II II NNP cord-015021-pol2qm74 1830 8 - - HYPH cord-015021-pol2qm74 1830 9 score score NN cord-015021-pol2qm74 1830 10 21±5 21±5 CD cord-015021-pol2qm74 1830 11 ) ) -RRB- cord-015021-pol2qm74 1830 12 with with IN cord-015021-pol2qm74 1830 13 diagnosis diagnosis NN cord-015021-pol2qm74 1830 14 of of IN cord-015021-pol2qm74 1830 15 SIRS SIRS NNP cord-015021-pol2qm74 1830 16 entered enter VBD cord-015021-pol2qm74 1830 17 the the DT cord-015021-pol2qm74 1830 18 study study NN cord-015021-pol2qm74 1830 19 . . . cord-015021-pol2qm74 1831 1 Granulocytes granulocyte NNS cord-015021-pol2qm74 1831 2 were be VBD cord-015021-pol2qm74 1831 3 prepared prepare VBN cord-015021-pol2qm74 1831 4 as as IN cord-015021-pol2qm74 1831 5 reported report VBN cord-015021-pol2qm74 1831 6 previously previously RB cord-015021-pol2qm74 1831 7 ( ( -LRB- cord-015021-pol2qm74 1831 8 2 2 CD cord-015021-pol2qm74 1831 9 ) ) -RRB- cord-015021-pol2qm74 1831 10 . . . cord-015021-pol2qm74 1832 1 In in IN cord-015021-pol2qm74 1832 2 parallel parallel NN cord-015021-pol2qm74 1832 3 , , , cord-015021-pol2qm74 1832 4 granulocytes granulocyte NNS cord-015021-pol2qm74 1832 5 from from IN cord-015021-pol2qm74 1832 6 20 20 CD cord-015021-pol2qm74 1832 7 healthy healthy JJ cord-015021-pol2qm74 1832 8 individuals individual NNS cord-015021-pol2qm74 1832 9 were be VBD cord-015021-pol2qm74 1832 10 tested test VBN cord-015021-pol2qm74 1832 11 . . . cord-015021-pol2qm74 1833 1 Two two CD cord-015021-pol2qm74 1833 2 granulocyte granulocyte NN cord-015021-pol2qm74 1833 3 functians functian NNS cord-015021-pol2qm74 1833 4 were be VBD cord-015021-pol2qm74 1833 5 studied study VBN cord-015021-pol2qm74 1833 6 in in IN cord-015021-pol2qm74 1833 7 vitro vitro FW cord-015021-pol2qm74 1833 8 : : : cord-015021-pol2qm74 1833 9 1 1 CD cord-015021-pol2qm74 1833 10 . . . cord-015021-pol2qm74 1834 1 Migration migration NN cord-015021-pol2qm74 1834 2 of of IN cord-015021-pol2qm74 1834 3 the the DT cord-015021-pol2qm74 1834 4 ceils ceil NNS cord-015021-pol2qm74 1834 5 in in IN cord-015021-pol2qm74 1834 6 a a DT cord-015021-pol2qm74 1834 7 boyden boyden NNP cord-015021-pol2qm74 1834 8 chamber chamber NN cord-015021-pol2qm74 1834 9 through through IN cord-015021-pol2qm74 1834 10 a a DT cord-015021-pol2qm74 1834 11 filter filter NN cord-015021-pol2qm74 1834 12 matrix matrix NN cord-015021-pol2qm74 1834 13 following follow VBG cord-015021-pol2qm74 1834 14 stimulation stimulation NN cord-015021-pol2qm74 1834 15 with with IN cord-015021-pol2qm74 1834 16 5 5 CD cord-015021-pol2qm74 1834 17 different different JJ cord-015021-pol2qm74 1834 18 receptor receptor NN cord-015021-pol2qm74 1834 19 dependent dependent JJ cord-015021-pol2qm74 1834 20 stimuli stimulus NNS cord-015021-pol2qm74 1834 21 ( ( -LRB- cord-015021-pol2qm74 1834 22 C5a C5a NNS cord-015021-pol2qm74 1834 23 , , , cord-015021-pol2qm74 1834 24 Intefleukin-8 Intefleukin-8 NNP cord-015021-pol2qm74 1834 25 , , , cord-015021-pol2qm74 1834 26 Platelet platelet NN cord-015021-pol2qm74 1834 27 - - HYPH cord-015021-pol2qm74 1834 28 activating activate VBG cord-015021-pol2qm74 1834 29 - - HYPH cord-015021-pol2qm74 1834 30 factor factor NN cord-015021-pol2qm74 1834 31 , , , cord-015021-pol2qm74 1834 32 Leukotrien Leukotrien NNP cord-015021-pol2qm74 1834 33 B4 B4 NNP cord-015021-pol2qm74 1834 34 , , , cord-015021-pol2qm74 1834 35 FMLP FMLP NNP cord-015021-pol2qm74 1834 36 ) ) -RRB- cord-015021-pol2qm74 1834 37 . . . cord-015021-pol2qm74 1835 1 2 2 LS cord-015021-pol2qm74 1835 2 . . . cord-015021-pol2qm74 1836 1 Release release NN cord-015021-pol2qm74 1836 2 of of IN cord-015021-pol2qm74 1836 3 13glucuronidase 13glucuronidase CD cord-015021-pol2qm74 1836 4 following follow VBG cord-015021-pol2qm74 1836 5 stimulation stimulation NN cord-015021-pol2qm74 1836 6 with with IN cord-015021-pol2qm74 1836 7 the the DT cord-015021-pol2qm74 1836 8 aforementioned aforementioned JJ cord-015021-pol2qm74 1836 9 activators activator NNS cord-015021-pol2qm74 1836 10 . . . cord-015021-pol2qm74 1837 1 The the DT cord-015021-pol2qm74 1837 2 results result NNS cord-015021-pol2qm74 1837 3 demonstrate demonstrate VBP cord-015021-pol2qm74 1837 4 , , , cord-015021-pol2qm74 1837 5 that that IN cord-015021-pol2qm74 1837 6 the the DT cord-015021-pol2qm74 1837 7 release release NN cord-015021-pol2qm74 1837 8 of of IN cord-015021-pol2qm74 1837 9 13-glucuronidase 13-glucuronidase CD cord-015021-pol2qm74 1837 10 in in IN cord-015021-pol2qm74 1837 11 patients patient NNS cord-015021-pol2qm74 1837 12 suffering suffer VBG cord-015021-pol2qm74 1837 13 from from IN cord-015021-pol2qm74 1837 14 SIRS SIRS NNP cord-015021-pol2qm74 1837 15 was be VBD cord-015021-pol2qm74 1837 16 comparable comparable JJ cord-015021-pol2qm74 1837 17 to to IN cord-015021-pol2qm74 1837 18 the the DT cord-015021-pol2qm74 1837 19 enzyme enzyme NN cord-015021-pol2qm74 1837 20 release release NN cord-015021-pol2qm74 1837 21 of of IN cord-015021-pol2qm74 1837 22 granulocytes granulocyte NNS cord-015021-pol2qm74 1837 23 prepared prepare VBN cord-015021-pol2qm74 1837 24 from from IN cord-015021-pol2qm74 1837 25 healthy healthy JJ cord-015021-pol2qm74 1837 26 individuals individual NNS cord-015021-pol2qm74 1837 27 . . . cord-015021-pol2qm74 1838 1 Each each DT cord-015021-pol2qm74 1838 2 stimulant stimulant NN cord-015021-pol2qm74 1838 3 induced induce VBN cord-015021-pol2qm74 1838 4 release release NN cord-015021-pol2qm74 1838 5 of of IN cord-015021-pol2qm74 1838 6 p p NN cord-015021-pol2qm74 1838 7 - - HYPH cord-015021-pol2qm74 1838 8 glucuronidase glucuronidase NN cord-015021-pol2qm74 1838 9 in in IN cord-015021-pol2qm74 1838 10 a a DT cord-015021-pol2qm74 1838 11 characteristic characteristic JJ cord-015021-pol2qm74 1838 12 dose dose NN cord-015021-pol2qm74 1838 13 dependent dependent JJ cord-015021-pol2qm74 1838 14 fashion fashion NN cord-015021-pol2qm74 1838 15 . . . cord-015021-pol2qm74 1839 1 All all DT cord-015021-pol2qm74 1839 2 granulocyte granulocyte NN cord-015021-pol2qm74 1839 3 preparations preparation NNS cord-015021-pol2qm74 1839 4 from from IN cord-015021-pol2qm74 1839 5 the the DT cord-015021-pol2qm74 1839 6 healthy healthy JJ cord-015021-pol2qm74 1839 7 donors donor NNS cord-015021-pol2qm74 1839 8 showed show VBD cord-015021-pol2qm74 1839 9 a a DT cord-015021-pol2qm74 1839 10 positive positive JJ cord-015021-pol2qm74 1839 11 chemotaxis chemotaxis NN cord-015021-pol2qm74 1839 12 response response NN cord-015021-pol2qm74 1839 13 in in IN cord-015021-pol2qm74 1839 14 the the DT cord-015021-pol2qm74 1839 15 migration migration NN cord-015021-pol2qm74 1839 16 - - HYPH cord-015021-pol2qm74 1839 17 assay assay NN cord-015021-pol2qm74 1839 18 . . . cord-015021-pol2qm74 1840 1 In in IN cord-015021-pol2qm74 1840 2 contrast contrast NN cord-015021-pol2qm74 1840 3 , , , cord-015021-pol2qm74 1840 4 only only RB cord-015021-pol2qm74 1840 5 ten ten CD cord-015021-pol2qm74 1840 6 out out IN cord-015021-pol2qm74 1840 7 of of IN cord-015021-pol2qm74 1840 8 twenty twenty CD cord-015021-pol2qm74 1840 9 - - HYPH cord-015021-pol2qm74 1840 10 one one CD cord-015021-pol2qm74 1840 11 patients patient NNS cord-015021-pol2qm74 1840 12 had have VBD cord-015021-pol2qm74 1840 13 granulocytes granulocyte NNS cord-015021-pol2qm74 1840 14 migrating migrate VBG cord-015021-pol2qm74 1840 15 after after IN cord-015021-pol2qm74 1840 16 stimulation stimulation NN cord-015021-pol2qm74 1840 17 . . . cord-015021-pol2qm74 1841 1 The the DT cord-015021-pol2qm74 1841 2 two two CD cord-015021-pol2qm74 1841 3 groups group NNS cord-015021-pol2qm74 1841 4 of of IN cord-015021-pol2qm74 1841 5 patients patient NNS cord-015021-pol2qm74 1841 6 displaying display VBG cord-015021-pol2qm74 1841 7 reactive reactive JJ cord-015021-pol2qm74 1841 8 or or CC cord-015021-pol2qm74 1841 9 non non JJ cord-015021-pol2qm74 1841 10 - - JJ cord-015021-pol2qm74 1841 11 reactive reactive JJ cord-015021-pol2qm74 1841 12 granulocytes granulocyte NNS cord-015021-pol2qm74 1841 13 differed differ VBD cord-015021-pol2qm74 1841 14 clinically clinically RB cord-015021-pol2qm74 1841 15 : : : cord-015021-pol2qm74 1841 16 The the DT cord-015021-pol2qm74 1841 17 nonreactive nonreactive JJ cord-015021-pol2qm74 1841 18 group group NN cord-015021-pol2qm74 1841 19 consisted consist VBD cord-015021-pol2qm74 1841 20 of of IN cord-015021-pol2qm74 1841 21 patients patient NNS cord-015021-pol2qm74 1841 22 with with IN cord-015021-pol2qm74 1841 23 multiple multiple JJ cord-015021-pol2qm74 1841 24 organ organ NN cord-015021-pol2qm74 1841 25 failure failure NN cord-015021-pol2qm74 1841 26 ( ( -LRB- cord-015021-pol2qm74 1841 27 10/11 10/11 CD cord-015021-pol2qm74 1841 28 ) ) -RRB- cord-015021-pol2qm74 1841 29 and and CC cord-015021-pol2qm74 1841 30 nonsurvivors nonsurvivors NNP cord-015021-pol2qm74 1841 31 ( ( -LRB- cord-015021-pol2qm74 1841 32 8/11 8/11 CD cord-015021-pol2qm74 1841 33 ) ) -RRB- cord-015021-pol2qm74 1841 34 , , , cord-015021-pol2qm74 1841 35 whereas whereas IN cord-015021-pol2qm74 1841 36 8/10 8/10 CD cord-015021-pol2qm74 1841 37 patients patient NNS cord-015021-pol2qm74 1841 38 in in IN cord-015021-pol2qm74 1841 39 the the DT cord-015021-pol2qm74 1841 40 reactive reactive JJ cord-015021-pol2qm74 1841 41 group group NN cord-015021-pol2qm74 1841 42 survived survive VBD cord-015021-pol2qm74 1841 43 . . . cord-015021-pol2qm74 1842 1 Thus thus RB cord-015021-pol2qm74 1842 2 , , , cord-015021-pol2qm74 1842 3 the the DT cord-015021-pol2qm74 1842 4 in in FW cord-015021-pol2qm74 1842 5 vitro vitro FW cord-015021-pol2qm74 1842 6 chemotaxis chemotaxis NN cord-015021-pol2qm74 1842 7 of of IN cord-015021-pol2qm74 1842 8 granulocytes granulocyte NNS cord-015021-pol2qm74 1842 9 is be VBZ cord-015021-pol2qm74 1842 10 impaired impair VBN cord-015021-pol2qm74 1842 11 in in IN cord-015021-pol2qm74 1842 12 a a DT cord-015021-pol2qm74 1842 13 subgroup subgroup NN cord-015021-pol2qm74 1842 14 of of IN cord-015021-pol2qm74 1842 15 patients patient NNS cord-015021-pol2qm74 1842 16 with with IN cord-015021-pol2qm74 1842 17 SIRS SIRS NNP cord-015021-pol2qm74 1842 18 . . . cord-015021-pol2qm74 1843 1 This this DT cord-015021-pol2qm74 1843 2 defect defect NN cord-015021-pol2qm74 1843 3 of of IN cord-015021-pol2qm74 1843 4 the the DT cord-015021-pol2qm74 1843 5 non non JJ cord-015021-pol2qm74 1843 6 - - JJ cord-015021-pol2qm74 1843 7 specific specific JJ cord-015021-pol2qm74 1843 8 host host NN cord-015021-pol2qm74 1843 9 defense defense NN cord-015021-pol2qm74 1843 10 may may MD cord-015021-pol2qm74 1843 11 contribute contribute VB cord-015021-pol2qm74 1843 12 to to IN cord-015021-pol2qm74 1843 13 poor poor JJ cord-015021-pol2qm74 1843 14 prognosis prognosis NN cord-015021-pol2qm74 1843 15 and and CC cord-015021-pol2qm74 1843 16 outcome outcome NN cord-015021-pol2qm74 1843 17 of of IN cord-015021-pol2qm74 1843 18 these these DT cord-015021-pol2qm74 1843 19 patients patient NNS cord-015021-pol2qm74 1843 20 . . . cord-015021-pol2qm74 1844 1 Dermatol Dermatol NNP cord-015021-pol2qm74 1844 2 . . . cord-015021-pol2qm74 1845 1 85 85 CD cord-015021-pol2qm74 1845 2 : : : cord-015021-pol2qm74 1845 3 194 194 CD cord-015021-pol2qm74 1845 4 - - SYM cord-015021-pol2qm74 1845 5 198 198 CD cord-015021-pol2qm74 1845 6 , , , cord-015021-pol2qm74 1845 7 1985 1985 CD cord-015021-pol2qm74 1845 8 Klinik Klinik NNP cord-015021-pol2qm74 1845 9 ffir ffir NN cord-015021-pol2qm74 1845 10 An~ An~ NNP cord-015021-pol2qm74 1846 1 isthesiologie isthesiologie NNP cord-015021-pol2qm74 1846 2 und und NNP cord-015021-pol2qm74 1847 1 Operative Operative NNP cord-015021-pol2qm74 1847 2 Intensivmedizin Intensivmedizin NNP cord-015021-pol2qm74 1847 3 der der NNP cord-015021-pol2qm74 1847 4 CAU CAU NNP cord-015021-pol2qm74 1847 5 Kiel Kiel NNP cord-015021-pol2qm74 1847 6 , , , cord-015021-pol2qm74 1847 7 Schwanenweg Schwanenweg NNP cord-015021-pol2qm74 1847 8 21 21 CD cord-015021-pol2qm74 1847 9 , , , cord-015021-pol2qm74 1847 10 24105 24105 CD cord-015021-pol2qm74 1847 11 Kiel Kiel NNP cord-015021-pol2qm74 1847 12 , , , cord-015021-pol2qm74 1847 13 Germany Germany NNP cord-015021-pol2qm74 1847 14 . . . cord-015021-pol2qm74 1848 1 Objectives objective NNS cord-015021-pol2qm74 1848 2 of of IN cord-015021-pol2qm74 1848 3 the the DT cord-015021-pol2qm74 1848 4 study study NN cord-015021-pol2qm74 1848 5 : : : cord-015021-pol2qm74 1848 6 Major major JJ cord-015021-pol2qm74 1848 7 emphasis emphasis NN cord-015021-pol2qm74 1848 8 has have VBZ cord-015021-pol2qm74 1848 9 been be VBN cord-015021-pol2qm74 1848 10 given give VBN cord-015021-pol2qm74 1848 11 to to IN cord-015021-pol2qm74 1848 12 the the DT cord-015021-pol2qm74 1848 13 analysis analysis NN cord-015021-pol2qm74 1848 14 of of IN cord-015021-pol2qm74 1848 15 interactions interaction NNS cord-015021-pol2qm74 1848 16 of of IN cord-015021-pol2qm74 1848 17 antibiotics antibiotic NNS cord-015021-pol2qm74 1848 18 with with IN cord-015021-pol2qm74 1848 19 microorganisms microorganism NNS cord-015021-pol2qm74 1848 20 . . . cord-015021-pol2qm74 1849 1 Effects effect NNS cord-015021-pol2qm74 1849 2 of of IN cord-015021-pol2qm74 1849 3 antibiotics antibiotic NNS cord-015021-pol2qm74 1849 4 on on IN cord-015021-pol2qm74 1849 5 cells cell NNS cord-015021-pol2qm74 1849 6 of of IN cord-015021-pol2qm74 1849 7 primary primary JJ cord-015021-pol2qm74 1849 8 host host NN cord-015021-pol2qm74 1849 9 defense defense NN cord-015021-pol2qm74 1849 10 mechanisms mechanism NNS cord-015021-pol2qm74 1849 11 , , , cord-015021-pol2qm74 1849 12 such such JJ cord-015021-pol2qm74 1849 13 as as IN cord-015021-pol2qm74 1849 14 the the DT cord-015021-pol2qm74 1849 15 neutrophils neutrophil NNS cord-015021-pol2qm74 1849 16 , , , cord-015021-pol2qm74 1849 17 are be VBP cord-015021-pol2qm74 1849 18 less less RBR cord-015021-pol2qm74 1849 19 well well RB cord-015021-pol2qm74 1849 20 known known JJ cord-015021-pol2qm74 1849 21 . . . cord-015021-pol2qm74 1850 1 Therefore therefore RB cord-015021-pol2qm74 1850 2 , , , cord-015021-pol2qm74 1850 3 attention attention NN cord-015021-pol2qm74 1850 4 has have VBZ cord-015021-pol2qm74 1850 5 been be VBN cord-015021-pol2qm74 1850 6 focused focus VBN cord-015021-pol2qm74 1850 7 on on IN cord-015021-pol2qm74 1850 8 clindamycin clindamycin NN cord-015021-pol2qm74 1850 9 , , , cord-015021-pol2qm74 1850 10 a a DT cord-015021-pol2qm74 1850 11 member member NN cord-015021-pol2qm74 1850 12 of of IN cord-015021-pol2qm74 1850 13 the the DT cord-015021-pol2qm74 1850 14 lincoseamide lincoseamide NNP cord-015021-pol2qm74 1850 15 family family NN cord-015021-pol2qm74 1850 16 . . . cord-015021-pol2qm74 1851 1 Materials material NNS cord-015021-pol2qm74 1851 2 and and CC cord-015021-pol2qm74 1851 3 methods method NNS cord-015021-pol2qm74 1851 4 : : : cord-015021-pol2qm74 1852 1 The the DT cord-015021-pol2qm74 1852 2 effect effect NN cord-015021-pol2qm74 1852 3 of of IN cord-015021-pol2qm74 1852 4 clindamycin clindamycin NN cord-015021-pol2qm74 1852 5 ( ( -LRB- cord-015021-pol2qm74 1852 6 i i PRP cord-015021-pol2qm74 1852 7 -i00 -i00 VBD cord-015021-pol2qm74 1853 1 ~g ~g NNP cord-015021-pol2qm74 1854 1 /ml /ml NFP cord-015021-pol2qm74 1854 2 ) ) -RRB- cord-015021-pol2qm74 1854 3 on on IN cord-015021-pol2qm74 1854 4 8 8 CD cord-015021-pol2qm74 1854 5 granulocyte granulocyte NN cord-015021-pol2qm74 1854 6 functions function NNS cord-015021-pol2qm74 1854 7 ( ( -LRB- cord-015021-pol2qm74 1854 8 healthy healthy JJ cord-015021-pol2qm74 1854 9 volunteers volunteer NNS cord-015021-pol2qm74 1854 10 ) ) -RRB- cord-015021-pol2qm74 1854 11 such such JJ cord-015021-pol2qm74 1854 12 as as IN cord-015021-pol2qm74 1854 13 random random JJ cord-015021-pol2qm74 1854 14 migration migration NN cord-015021-pol2qm74 1854 15 , , , cord-015021-pol2qm74 1854 16 chemotaxis chemotaxis NN cord-015021-pol2qm74 1854 17 ( ( -LRB- cord-015021-pol2qm74 1854 18 agarose agarose JJ cord-015021-pol2qm74 1854 19 method method NN cord-015021-pol2qm74 1854 20 ) ) -RRB- cord-015021-pol2qm74 1854 21 , , , cord-015021-pol2qm74 1854 22 ingestion ingestion NN cord-015021-pol2qm74 1854 23 ( ( -LRB- cord-015021-pol2qm74 1854 24 radiometric radiometric JJ cord-015021-pol2qm74 1854 25 assay assay NN cord-015021-pol2qm74 1854 26 ) ) -RRB- cord-015021-pol2qm74 1854 27 , , , cord-015021-pol2qm74 1854 28 superoxide superoxide NN cord-015021-pol2qm74 1854 29 ( ( -LRB- cord-015021-pol2qm74 1854 30 cytochrom cytochrom NNP cord-015021-pol2qm74 1854 31 c c NNP cord-015021-pol2qm74 1854 32 reduction reduction NN cord-015021-pol2qm74 1854 33 ) ) -RRB- cord-015021-pol2qm74 1854 34 and and CC cord-015021-pol2qm74 1854 35 hydrogen hydrogen NN cord-015021-pol2qm74 1854 36 peroxide peroxide NN cord-015021-pol2qm74 1854 37 production production NN cord-015021-pol2qm74 1854 38 ( ( -LRB- cord-015021-pol2qm74 1854 39 phenol phenol NN cord-015021-pol2qm74 1854 40 red red JJ cord-015021-pol2qm74 1854 41 oxidation oxidation NN cord-015021-pol2qm74 1854 42 ) ) -RRB- cord-015021-pol2qm74 1854 43 , , , cord-015021-pol2qm74 1854 44 lucigenin lucigenin NNP cord-015021-pol2qm74 1854 45 - - HYPH cord-015021-pol2qm74 1854 46 and and CC cord-015021-pol2qm74 1854 47 luminol luminol NN cord-015021-pol2qm74 1854 48 - - HYPH cord-015021-pol2qm74 1854 49 amplified amplify VBN cord-015021-pol2qm74 1854 50 chemiluminescence chemiluminescence NN cord-015021-pol2qm74 1854 51 ( ( -LRB- cord-015021-pol2qm74 1854 52 luminometry luminometry NNP cord-015021-pol2qm74 1854 53 ) ) -RRB- cord-015021-pol2qm74 1854 54 and and CC cord-015021-pol2qm74 1854 55 degranulation degranulation NN cord-015021-pol2qm74 1854 56 ( ( -LRB- cord-015021-pol2qm74 1854 57 turbidometry turbidometry NN cord-015021-pol2qm74 1854 58 with with IN cord-015021-pol2qm74 1854 59 Micrococcus Micrococcus NNP cord-015021-pol2qm74 1854 60 lysodeicticus lysodeicticus NNP cord-015021-pol2qm74 1854 61 ) ) -RRB- cord-015021-pol2qm74 1854 62 were be VBD cord-015021-pol2qm74 1854 63 investigated investigate VBN cord-015021-pol2qm74 1854 64 in in IN cord-015021-pol2qm74 1854 65 vitro vitro FW cord-015021-pol2qm74 1854 66 . . . cord-015021-pol2qm74 1855 1 Results result NNS cord-015021-pol2qm74 1855 2 : : : cord-015021-pol2qm74 1856 1 Motility motility NN cord-015021-pol2qm74 1856 2 and and CC cord-015021-pol2qm74 1856 3 degranulation degranulation NN cord-015021-pol2qm74 1856 4 were be VBD cord-015021-pol2qm74 1856 5 inhibited inhibit VBN cord-015021-pol2qm74 1856 6 , , , cord-015021-pol2qm74 1856 7 ingestion ingestion NN cord-015021-pol2qm74 1856 8 of of IN cord-015021-pol2qm74 1856 9 Saccharomyces Saccharomyces NNP cord-015021-pol2qm74 1856 10 cerevisiae cerevisiae NNS cord-015021-pol2qm74 1856 11 , , , cord-015021-pol2qm74 1856 12 zymosan zymosan NNP cord-015021-pol2qm74 1856 13 - - HYPH cord-015021-pol2qm74 1856 14 induced induce VBN cord-015021-pol2qm74 1856 15 lucigenin lucigenin NNP cord-015021-pol2qm74 1856 16 - - HYPH cord-015021-pol2qm74 1856 17 and and CC cord-015021-pol2qm74 1856 18 luminol luminol NN cord-015021-pol2qm74 1856 19 - - HYPH cord-015021-pol2qm74 1856 20 amplified amplify VBN cord-015021-pol2qm74 1856 21 chemiluminescence chemiluminescence NN cord-015021-pol2qm74 1856 22 , , , cord-015021-pol2qm74 1856 23 superoxide superoxide NN cord-015021-pol2qm74 1856 24 and and CC cord-015021-pol2qm74 1856 25 hydrogen hydrogen NN cord-015021-pol2qm74 1856 26 peroxide peroxide NN cord-015021-pol2qm74 1856 27 production production NN cord-015021-pol2qm74 1856 28 were be VBD cord-015021-pol2qm74 1856 29 stimulated stimulate VBN cord-015021-pol2qm74 1856 30 in in IN cord-015021-pol2qm74 1856 31 a a DT cord-015021-pol2qm74 1856 32 dose dose JJ cord-015021-pol2qm74 1856 33 dependent dependent JJ cord-015021-pol2qm74 1856 34 fashion fashion NN cord-015021-pol2qm74 1856 35 . . . cord-015021-pol2qm74 1857 1 Conclusion conclusion NN cord-015021-pol2qm74 1857 2 : : : cord-015021-pol2qm74 1858 1 Clindamycin Clindamycin NNP cord-015021-pol2qm74 1858 2 has have VBZ cord-015021-pol2qm74 1858 3 granulocyte granulocyte NN cord-015021-pol2qm74 1858 4 function function NN cord-015021-pol2qm74 1858 5 modulating modulate VBG cord-015021-pol2qm74 1858 6 properties property NNS cord-015021-pol2qm74 1858 7 . . . cord-015021-pol2qm74 1859 1 Recognition recognition NN cord-015021-pol2qm74 1859 2 of of IN cord-015021-pol2qm74 1859 3 immunomodulating immunomodulating JJ cord-015021-pol2qm74 1859 4 effects effect NNS cord-015021-pol2qm74 1859 5 of of IN cord-015021-pol2qm74 1859 6 antibiotics antibiotic NNS cord-015021-pol2qm74 1859 7 may may MD cord-015021-pol2qm74 1859 8 have have VB cord-015021-pol2qm74 1859 9 therapeutic therapeutic JJ cord-015021-pol2qm74 1859 10 significance significance NN cord-015021-pol2qm74 1859 11 , , , cord-015021-pol2qm74 1859 12 especially especially RB cord-015021-pol2qm74 1859 13 in in IN cord-015021-pol2qm74 1859 14 patients patient NNS cord-015021-pol2qm74 1859 15 with with IN cord-015021-pol2qm74 1859 16 long long JJ cord-015021-pol2qm74 1859 17 - - HYPH cord-015021-pol2qm74 1859 18 term term NN cord-015021-pol2qm74 1859 19 antibiotic antibiotic JJ cord-015021-pol2qm74 1859 20 therapy therapy NN cord-015021-pol2qm74 1859 21 or or CC cord-015021-pol2qm74 1859 22 immune immune JJ cord-015021-pol2qm74 1859 23 deficiencies deficiency NNS cord-015021-pol2qm74 1859 24 . . . cord-015021-pol2qm74 1860 1 The the DT cord-015021-pol2qm74 1860 2 intense intense JJ cord-015021-pol2qm74 1860 3 muscle muscle NN cord-015021-pol2qm74 1860 4 activity activity NN cord-015021-pol2qm74 1860 5 ( ( -LRB- cord-015021-pol2qm74 1860 6 EA EA NNP cord-015021-pol2qm74 1860 7 ) ) -RRB- cord-015021-pol2qm74 1860 8 of of IN cord-015021-pol2qm74 1860 9 rats rat NNS cord-015021-pol2qm74 1860 10 resulted result VBD cord-015021-pol2qm74 1860 11 in in IN cord-015021-pol2qm74 1860 12 increase increase NN cord-015021-pol2qm74 1860 13 of of IN cord-015021-pol2qm74 1860 14 neutrophil neutrophil NN cord-015021-pol2qm74 1860 15 influx influx NN cord-015021-pol2qm74 1860 16 in in IN cord-015021-pol2qm74 1860 17 muscles muscle NNS cord-015021-pol2qm74 1860 18 during during IN cord-015021-pol2qm74 1860 19 the the DT cord-015021-pol2qm74 1860 20 recovery recovery NN cord-015021-pol2qm74 1860 21 . . . cord-015021-pol2qm74 1861 1 We -PRON- PRP cord-015021-pol2qm74 1861 2 investigated investigate VBD cord-015021-pol2qm74 1861 3 neutrophil neutrophil NN cord-015021-pol2qm74 1861 4 proteinases proteinases NNP cord-015021-pol2qm74 1861 5 involvement involvement NN cord-015021-pol2qm74 1861 6 in in IN cord-015021-pol2qm74 1861 7 neutral neutral JJ cord-015021-pol2qm74 1861 8 proteinases proteinases JJ cord-015021-pol2qm74 1861 9 balance balance NN cord-015021-pol2qm74 1861 10 of of IN cord-015021-pol2qm74 1861 11 skeletal skeletal JJ cord-015021-pol2qm74 1861 12 muscles muscle NNS cord-015021-pol2qm74 1861 13 by by IN cord-015021-pol2qm74 1861 14 NA NA NNP cord-015021-pol2qm74 1861 15 . . . cord-015021-pol2qm74 1862 1 The the DT cord-015021-pol2qm74 1862 2 rats rat NNS cord-015021-pol2qm74 1862 3 were be VBD cord-015021-pol2qm74 1862 4 submited submit VBN cord-015021-pol2qm74 1862 5 to to TO cord-015021-pol2qm74 1862 6 swim swim VB cord-015021-pol2qm74 1862 7 with with IN cord-015021-pol2qm74 1862 8 the the DT cord-015021-pol2qm74 1862 9 load load NN cord-015021-pol2qm74 1862 10 ( ( -LRB- cord-015021-pol2qm74 1862 11 8 8 CD cord-015021-pol2qm74 1862 12 % % NN cord-015021-pol2qm74 1862 13 of of IN cord-015021-pol2qm74 1862 14 body body NN cord-015021-pol2qm74 1862 15 mass mass NN cord-015021-pol2qm74 1862 16 ) ) -RRB- cord-015021-pol2qm74 1862 17 till till IN cord-015021-pol2qm74 1862 18 exhaustion exhaustion NN cord-015021-pol2qm74 1862 19 . . . cord-015021-pol2qm74 1863 1 Immediately immediately RB cord-015021-pol2qm74 1863 2 after after IN cord-015021-pol2qm74 1863 3 NA NA NNP cord-015021-pol2qm74 1863 4 the the DT cord-015021-pol2qm74 1863 5 neutrophil neutrophil NN cord-015021-pol2qm74 1863 6 antiserum antiserum NN cord-015021-pol2qm74 1863 7 was be VBD cord-015021-pol2qm74 1863 8 injected inject VBN cord-015021-pol2qm74 1863 9 i.p i.p NNP cord-015021-pol2qm74 1863 10 . . NNP cord-015021-pol2qm74 1863 11 to to IN cord-015021-pol2qm74 1863 12 rats rat NNS cord-015021-pol2qm74 1863 13 of of IN cord-015021-pol2qm74 1863 14 experimental experimental JJ cord-015021-pol2qm74 1863 15 group group NN cord-015021-pol2qm74 1863 16 . . . cord-015021-pol2qm74 1864 1 Saline Saline NNP cord-015021-pol2qm74 1864 2 was be VBD cord-015021-pol2qm74 1864 3 injected inject VBN cord-015021-pol2qm74 1864 4 to to TO cord-015021-pol2qm74 1864 5 control control VB cord-015021-pol2qm74 1864 6 animals animal NNS cord-015021-pol2qm74 1864 7 ° ° NNS cord-015021-pol2qm74 1864 8 Injections injection NNS cord-015021-pol2qm74 1864 9 were be VBD cord-015021-pol2qm74 1864 10 repeated repeat VBN cord-015021-pol2qm74 1864 11 in in IN cord-015021-pol2qm74 1864 12 12 12 CD cord-015021-pol2qm74 1864 13 h h NN cord-015021-pol2qm74 1864 14 of of IN cord-015021-pol2qm74 1864 15 the the DT cord-015021-pol2qm74 1864 16 recovery recovery NN cord-015021-pol2qm74 1864 17 and and CC cord-015021-pol2qm74 1864 18 cytosol cytosol NN cord-015021-pol2qm74 1864 19 proteolytic proteolytic JJ cord-015021-pol2qm74 1864 20 activity activity NN cord-015021-pol2qm74 1864 21 ( ( -LRB- cord-015021-pol2qm74 1864 22 pH pH NNP cord-015021-pol2qm74 1864 23 7.4 7.4 CD cord-015021-pol2qm74 1864 24 ; ; : cord-015021-pol2qm74 1864 25 FITC FITC NNP cord-015021-pol2qm74 1864 26 - - HYPH cord-015021-pol2qm74 1864 27 casein casein NN cord-015021-pol2qm74 1864 28 ) ) -RRB- cord-015021-pol2qm74 1864 29 was be VBD cord-015021-pol2qm74 1864 30 determined determine VBN cord-015021-pol2qm74 1864 31 . . . cord-015021-pol2qm74 1865 1 Isolated isolated JJ cord-015021-pol2qm74 1865 2 soleus soleus NN cord-015021-pol2qm74 1865 3 muscles muscle NNS cord-015021-pol2qm74 1865 4 were be VBD cord-015021-pol2qm74 1865 5 incubated incubate VBN cord-015021-pol2qm74 1865 6 also also RB cord-015021-pol2qm74 1865 7 in in IN cord-015021-pol2qm74 1865 8 vitro vitro FW cord-015021-pol2qm74 1865 9 and and CC cord-015021-pol2qm74 1865 10 proteolytic proteolytic JJ cord-015021-pol2qm74 1865 11 activity activity NN cord-015021-pol2qm74 1865 12 of of IN cord-015021-pol2qm74 1865 13 incubation incubation NN cord-015021-pol2qm74 1865 14 media medium NNS cord-015021-pol2qm74 1865 15 was be VBD cord-015021-pol2qm74 1865 16 measured measure VBN cord-015021-pol2qm74 1865 17 . . . cord-015021-pol2qm74 1866 1 It -PRON- PRP cord-015021-pol2qm74 1866 2 was be VBD cord-015021-pol2qm74 1866 3 found find VBN cord-015021-pol2qm74 1866 4 that that IN cord-015021-pol2qm74 1866 5 there there EX cord-015021-pol2qm74 1866 6 was be VBD cord-015021-pol2qm74 1866 7 2 2 CD cord-015021-pol2qm74 1866 8 - - SYM cord-015021-pol2qm74 1866 9 3 3 CD cord-015021-pol2qm74 1866 10 -fold -fold NN cord-015021-pol2qm74 1866 11 proteinases proteinase NNS cord-015021-pol2qm74 1866 12 activity activity NN cord-015021-pol2qm74 1866 13 increase increase NN cord-015021-pol2qm74 1866 14 in in IN cord-015021-pol2qm74 1866 15 cytosols cytosol NNS cord-015021-pol2qm74 1866 16 of of IN cord-015021-pol2qm74 1866 17 all all DT cord-015021-pol2qm74 1866 18 investigated investigate VBN cord-015021-pol2qm74 1866 19 muscles muscle NNS cord-015021-pol2qm74 1866 20 ( ( -LRB- cord-015021-pol2qm74 1866 21 soleus soleus NN cord-015021-pol2qm74 1866 22 , , , cord-015021-pol2qm74 1866 23 white white JJ cord-015021-pol2qm74 1866 24 and and CC cord-015021-pol2qm74 1866 25 red red JJ cord-015021-pol2qm74 1866 26 portions portion NNS cord-015021-pol2qm74 1866 27 of of IN cord-015021-pol2qm74 1866 28 quadriceps quadricep NNS cord-015021-pol2qm74 1866 29 ) ) -RRB- cord-015021-pol2qm74 1866 30 of of IN cord-015021-pol2qm74 1866 31 control control NN cord-015021-pol2qm74 1866 32 animals animal NNS cord-015021-pol2qm74 1866 33 by by IN cord-015021-pol2qm74 1866 34 6 6 CD cord-015021-pol2qm74 1866 35 h h NN cord-015021-pol2qm74 1866 36 of of IN cord-015021-pol2qm74 1866 37 the the DT cord-015021-pol2qm74 1866 38 recovery recovery NN cord-015021-pol2qm74 1866 39 ( ( -LRB- cord-015021-pol2qm74 1866 40 the the DT cord-015021-pol2qm74 1866 41 comparison comparison NN cord-015021-pol2qm74 1866 42 was be VBD cord-015021-pol2qm74 1866 43 done do VBN cord-015021-pol2qm74 1866 44 with with IN cord-015021-pol2qm74 1866 45 the the DT cord-015021-pol2qm74 1866 46 sedentary sedentary JJ cord-015021-pol2qm74 1866 47 rats rat NNS cord-015021-pol2qm74 1866 48 ) ) -RRB- cord-015021-pol2qm74 1866 49 . . . cord-015021-pol2qm74 1867 1 In in IN cord-015021-pol2qm74 1867 2 12 12 CD cord-015021-pol2qm74 1867 3 h h NN cord-015021-pol2qm74 1867 4 cytosol cytosol NN cord-015021-pol2qm74 1867 5 proteolytic proteolytic JJ cord-015021-pol2qm74 1867 6 activity activity NN cord-015021-pol2qm74 1867 7 decreased decrease VBD cord-015021-pol2qm74 1867 8 and and CC cord-015021-pol2qm74 1867 9 then then RB cord-015021-pol2qm74 1867 10 increased increase VBD cord-015021-pol2qm74 1867 11 again again RB cord-015021-pol2qm74 1867 12 by by IN cord-015021-pol2qm74 1867 13 24 24 CD cord-015021-pol2qm74 1867 14 h h NN cord-015021-pol2qm74 1867 15 of of IN cord-015021-pol2qm74 1867 16 the the DT cord-015021-pol2qm74 1867 17 fast fast NN cord-015021-pol2qm74 1867 18 . . . cord-015021-pol2qm74 1868 1 Antiserum antiserum NN cord-015021-pol2qm74 1868 2 injections injection NNS cord-015021-pol2qm74 1868 3 resulted result VBD cord-015021-pol2qm74 1868 4 in in IN cord-015021-pol2qm74 1868 5 relible relible JJ cord-015021-pol2qm74 1868 6 decrease decrease NN cord-015021-pol2qm74 1868 7 of of IN cord-015021-pol2qm74 1868 8 the the DT cord-015021-pol2qm74 1868 9 proteolytic proteolytic JJ cord-015021-pol2qm74 1868 10 activities activity NNS cord-015021-pol2qm74 1868 11 at at IN cord-015021-pol2qm74 1868 12 every every DT cord-015021-pol2qm74 1868 13 investigated investigate VBN cord-015021-pol2qm74 1868 14 time time NN cord-015021-pol2qm74 1868 15 . . . cord-015021-pol2qm74 1869 1 When when WRB cord-015021-pol2qm74 1869 2 incubating incubate VBG cord-015021-pol2qm74 1869 3 m. m. NN cord-015021-pol2qm74 1869 4 soleus soleus NN cord-015021-pol2qm74 1869 5 in in IN cord-015021-pol2qm74 1869 6 vitro vitro FW cord-015021-pol2qm74 1869 7 the the DT cord-015021-pol2qm74 1869 8 activities activity NNS cord-015021-pol2qm74 1869 9 of of IN cord-015021-pol2qm74 1869 10 proteinases proteinases NNP cord-015021-pol2qm74 1869 11 in in IN cord-015021-pol2qm74 1869 12 incubation incubation NN cord-015021-pol2qm74 1869 13 media medium NNS cord-015021-pol2qm74 1869 14 turned turn VBD cord-015021-pol2qm74 1869 15 out out RP cord-015021-pol2qm74 1869 16 reliably reliably RB cord-015021-pol2qm74 1869 17 less less RBR cord-015021-pol2qm74 1869 18 if if IN cord-015021-pol2qm74 1869 19 soleus soleus NN cord-015021-pol2qm74 1869 20 muscles muscle NNS cord-015021-pol2qm74 1869 21 were be VBD cord-015021-pol2qm74 1869 22 isolated isolate VBN cord-015021-pol2qm74 1869 23 from from IN cord-015021-pol2qm74 1869 24 the the DT cord-015021-pol2qm74 1869 25 animals animal NNS cord-015021-pol2qm74 1869 26 to to TO cord-015021-pol2qm74 1869 27 which which WDT cord-015021-pol2qm74 1869 28 antiserum antiserum NN cord-015021-pol2qm74 1869 29 was be VBD cord-015021-pol2qm74 1869 30 injected inject VBN cord-015021-pol2qm74 1869 31 . . . cord-015021-pol2qm74 1870 1 The the DT cord-015021-pol2qm74 1870 2 conclusion conclusion NN cord-015021-pol2qm74 1870 3 is be VBZ cord-015021-pol2qm74 1870 4 that that IN cord-015021-pol2qm74 1870 5 neutrophil neutrophil NN cord-015021-pol2qm74 1870 6 proteinases proteinase NNS cord-015021-pol2qm74 1870 7 can can MD cord-015021-pol2qm74 1870 8 be be VB cord-015021-pol2qm74 1870 9 involved involve VBN cord-015021-pol2qm74 1870 10 in in IN cord-015021-pol2qm74 1870 11 the the DT cord-015021-pol2qm74 1870 12 balance balance NN cord-015021-pol2qm74 1870 13 of of IN cord-015021-pol2qm74 1870 14 rat rat NN cord-015021-pol2qm74 1870 15 skeletal skeletal JJ cord-015021-pol2qm74 1870 16 muscle muscle NN cord-015021-pol2qm74 1870 17 neutral neutral JJ cord-015021-pol2qm74 1870 18 proteinases proteinase NNS cord-015021-pol2qm74 1870 19 after after IN cord-015021-pol2qm74 1870 20 ~A. ~a. JJ cord-015021-pol2qm74 1871 1 A a DT cord-015021-pol2qm74 1871 2 lot lot NN cord-015021-pol2qm74 1871 3 and and CC cord-015021-pol2qm74 1871 4 new new JJ cord-015021-pol2qm74 1871 5 clinical clinical JJ cord-015021-pol2qm74 1871 6 problems problem NNS cord-015021-pol2qm74 1871 7 complicating complicate VBG cord-015021-pol2qm74 1871 8 the the DT cord-015021-pol2qm74 1871 9 outcome outcome NN cord-015021-pol2qm74 1871 10 of of IN cord-015021-pol2qm74 1871 11 polytrauma polytrauma NNP cord-015021-pol2qm74 1871 12 , , , cord-015021-pol2qm74 1871 13 burn burn VB cord-015021-pol2qm74 1871 14 and and CC cord-015021-pol2qm74 1871 15 septic septic JJ cord-015021-pol2qm74 1871 16 patients patient NNS cord-015021-pol2qm74 1871 17 in in IN cord-015021-pol2qm74 1871 18 Surgical Surgical NNP cord-015021-pol2qm74 1871 19 Intensive Intensive NNP cord-015021-pol2qm74 1871 20 Care Care NNP cord-015021-pol2qm74 1871 21 Units Units NNPS cord-015021-pol2qm74 1871 22 , , , cord-015021-pol2qm74 1871 23 have have VBP cord-015021-pol2qm74 1871 24 arisen arise VBN cord-015021-pol2qm74 1871 25 as as IN cord-015021-pol2qm74 1871 26 the the DT cord-015021-pol2qm74 1871 27 care care NN cord-015021-pol2qm74 1871 28 improvement improvement NN cord-015021-pol2qm74 1871 29 prolonged prolong VBD cord-015021-pol2qm74 1871 30 the the DT cord-015021-pol2qm74 1871 31 patient patient NN cord-015021-pol2qm74 1871 32 's 's POS cord-015021-pol2qm74 1871 33 survival survival NN cord-015021-pol2qm74 1871 34 : : : cord-015021-pol2qm74 1871 35 a a DT cord-015021-pol2qm74 1871 36 progressive progressive JJ cord-015021-pol2qm74 1871 37 degradation degradation NN cord-015021-pol2qm74 1871 38 of of IN cord-015021-pol2qm74 1871 39 organ organ NN cord-015021-pol2qm74 1871 40 and and CC cord-015021-pol2qm74 1871 41 system system NN cord-015021-pol2qm74 1871 42 functions function NNS cord-015021-pol2qm74 1871 43 often often RB cord-015021-pol2qm74 1871 44 develops develop VBZ cord-015021-pol2qm74 1871 45 , , , cord-015021-pol2qm74 1871 46 usually usually RB cord-015021-pol2qm74 1871 47 making make VBG cord-015021-pol2qm74 1871 48 its -PRON- PRP$ cord-015021-pol2qm74 1871 49 first first JJ cord-015021-pol2qm74 1871 50 clinical clinical JJ cord-015021-pol2qm74 1871 51 appearance appearance NN cord-015021-pol2qm74 1871 52 by by IN cord-015021-pol2qm74 1871 53 ARDS ARDS NNP cord-015021-pol2qm74 1871 54 , , , cord-015021-pol2qm74 1871 55 followed follow VBN cord-015021-pol2qm74 1871 56 by by IN cord-015021-pol2qm74 1871 57 the the DT cord-015021-pol2qm74 1871 58 other other JJ cord-015021-pol2qm74 1871 59 organ organ NN cord-015021-pol2qm74 1871 60 failure failure NN cord-015021-pol2qm74 1871 61 ( ( -LRB- cord-015021-pol2qm74 1871 62 MOF MOF NNP cord-015021-pol2qm74 1871 63 ) ) -RRB- cord-015021-pol2qm74 1871 64 and and CC cord-015021-pol2qm74 1871 65 sepsis sepsis NN cord-015021-pol2qm74 1871 66 symptoms symptom NNS cord-015021-pol2qm74 1871 67 . . . cord-015021-pol2qm74 1872 1 The the DT cord-015021-pol2qm74 1872 2 clinical clinical JJ cord-015021-pol2qm74 1872 3 picture picture NN cord-015021-pol2qm74 1872 4 is be VBZ cord-015021-pol2qm74 1872 5 polymorphic polymorphic JJ cord-015021-pol2qm74 1872 6 , , , cord-015021-pol2qm74 1872 7 the the DT cord-015021-pol2qm74 1872 8 end end NN cord-015021-pol2qm74 1872 9 result result NN cord-015021-pol2qm74 1872 10 of of IN cord-015021-pol2qm74 1872 11 a a DT cord-015021-pol2qm74 1872 12 complex complex JJ cord-015021-pol2qm74 1872 13 systemic systemic JJ cord-015021-pol2qm74 1872 14 pathophysiological pathophysiological JJ cord-015021-pol2qm74 1872 15 reaction reaction NN cord-015021-pol2qm74 1872 16 trigg trigg NNP cord-015021-pol2qm74 1872 17 ~ ~ NFP cord-015021-pol2qm74 1872 18 ed ed NNP cord-015021-pol2qm74 1872 19 off off RP cord-015021-pol2qm74 1872 20 by by IN cord-015021-pol2qm74 1872 21 trauma trauma NN cord-015021-pol2qm74 1872 22 consequences consequence NNS cord-015021-pol2qm74 1872 23 ( ( -LRB- cord-015021-pol2qm74 1872 24 tissues tissue NNS cord-015021-pol2qm74 1872 25 disruption disruption NN cord-015021-pol2qm74 1872 26 , , , cord-015021-pol2qm74 1872 27 hypo hypo NNP cord-015021-pol2qm74 1872 28 ~ ~ NFP cord-015021-pol2qm74 1872 29 xygenatiun xygenatiun NNP cord-015021-pol2qm74 1872 30 and and CC cord-015021-pol2qm74 1872 31 necrosis necrosis NN cord-015021-pol2qm74 1872 32 ) ) -RRB- cord-015021-pol2qm74 1872 33 . . . cord-015021-pol2qm74 1873 1 Nowadays nowadays RB cord-015021-pol2qm74 1873 2 there there EX cord-015021-pol2qm74 1873 3 is be VBZ cord-015021-pol2qm74 1873 4 not not RB cord-015021-pol2qm74 1873 5 a a DT cord-015021-pol2qm74 1873 6 preventi~ preventi~ JJ cord-015021-pol2qm74 1873 7 or or CC cord-015021-pol2qm74 1873 8 specific specific JJ cord-015021-pol2qm74 1873 9 therapy therapy NN cord-015021-pol2qm74 1873 10 to to TO cord-015021-pol2qm74 1873 11 lower lower VB cord-015021-pol2qm74 1873 12 the the DT cord-015021-pol2qm74 1873 13 mortality mortality NN cord-015021-pol2qm74 1873 14 rate rate NN cord-015021-pol2qm74 1873 15 ( ( -LRB- cord-015021-pol2qm74 1873 16 70 70 CD cord-015021-pol2qm74 1873 17 - - SYM cord-015021-pol2qm74 1873 18 80 80 CD cord-015021-pol2qm74 1873 19 % % NN cord-015021-pol2qm74 1873 20 ) ) -RRB- cord-015021-pol2qm74 1874 1 and-'mdy and-'mdy NNP cord-015021-pol2qm74 1874 2 - - : cord-015021-pol2qm74 1874 3 a~ a~ '' cord-015021-pol2qm74 1875 1 early early RB cord-015021-pol2qm74 1875 2 , , , cord-015021-pol2qm74 1875 3 aggressive aggressive JJ cord-015021-pol2qm74 1875 4 surgical surgical JJ cord-015021-pol2qm74 1875 5 approach approach NN cord-015021-pol2qm74 1875 6 .-evacuating .-evacuating . cord-015021-pol2qm74 1876 1 haematomas haematomas NNP cord-015021-pol2qm74 1876 2 , , , cord-015021-pol2qm74 1876 3 stopping stop VBG cord-015021-pol2qm74 1876 4 bleeding bleed VBG cord-015021-pol2qm74 1876 5 , , , cord-015021-pol2qm74 1876 6 toileting toilete VBG cord-015021-pol2qm74 1876 7 all all DT cord-015021-pol2qm74 1876 8 septic septic JJ cord-015021-pol2qm74 1876 9 , , , cord-015021-pol2qm74 1876 10 necrotic necrotic JJ cord-015021-pol2qm74 1876 11 foci foci NN cord-015021-pol2qm74 1876 12 and and CC cord-015021-pol2qm74 1876 13 restoring restore VBG cord-015021-pol2qm74 1876 14 anatomic anatomic JJ cord-015021-pol2qm74 1876 15 continuity- continuity- NN cord-015021-pol2qm74 1876 16 , , , cord-015021-pol2qm74 1876 17 seems seem VBZ cord-015021-pol2qm74 1876 18 to to TO cord-015021-pol2qm74 1876 19 be be VB cord-015021-pol2qm74 1876 20 of of IN cord-015021-pol2qm74 1876 21 some some DT cord-015021-pol2qm74 1876 22 help help NN cord-015021-pol2qm74 1876 23 This this DT cord-015021-pol2qm74 1876 24 complex complex JJ cord-015021-pol2qm74 1876 25 clinical clinical JJ cord-015021-pol2qm74 1876 26 entity entity NN cord-015021-pol2qm74 1876 27 has have VBZ cord-015021-pol2qm74 1876 28 not not RB cord-015021-pol2qm74 1876 29 an an DT cord-015021-pol2qm74 1876 30 univocal univocal JJ cord-015021-pol2qm74 1876 31 denomination denomination NN cord-015021-pol2qm74 1876 32 yet yet RB cord-015021-pol2qm74 1876 33 . . . cord-015021-pol2qm74 1877 1 The the DT cord-015021-pol2qm74 1877 2 proper proper JJ cord-015021-pol2qm74 1877 3 labelling labelling NN cord-015021-pol2qm74 1877 4 of of IN cord-015021-pol2qm74 1877 5 an an DT cord-015021-pol2qm74 1877 6 illness illness NN cord-015021-pol2qm74 1877 7 should should MD cord-015021-pol2qm74 1877 8 come come VB cord-015021-pol2qm74 1877 9 from from IN cord-015021-pol2qm74 1877 10 the the DT cord-015021-pol2qm74 1877 11 full full JJ cord-015021-pol2qm74 1877 12 understanding understanding NN cord-015021-pol2qm74 1877 13 of of IN cord-015021-pol2qm74 1877 14 its -PRON- PRP$ cord-015021-pol2qm74 1877 15 pathopysiology pathopysiology NN cord-015021-pol2qm74 1877 16 and and CC cord-015021-pol2qm74 1877 17 suggest suggest VBP cord-015021-pol2qm74 1877 18 the the DT cord-015021-pol2qm74 1877 19 proper proper JJ cord-015021-pol2qm74 1877 20 treatment treatment NN cord-015021-pol2qm74 1877 21 choice choice NN cord-015021-pol2qm74 1877 22 . . . cord-015021-pol2qm74 1878 1 Clinical clinical JJ cord-015021-pol2qm74 1878 2 and and CC cord-015021-pol2qm74 1878 3 experimental experimental JJ cord-015021-pol2qm74 1878 4 studies study NNS cord-015021-pol2qm74 1878 5 demonstrated demonstrate VBD cord-015021-pol2qm74 1878 6 that that IN cord-015021-pol2qm74 1878 7 pathophysiologic pathophysiologic NN cord-015021-pol2qm74 1878 8 mechanisms mechanism NNS cord-015021-pol2qm74 1878 9 involved involve VBN cord-015021-pol2qm74 1878 10 in in IN cord-015021-pol2qm74 1878 11 the the DT cord-015021-pol2qm74 1878 12 past past JJ cord-015021-pol2qm74 1878 13 - - HYPH cord-015021-pol2qm74 1878 14 traumatic traumatic JJ cord-015021-pol2qm74 1878 15 illness illness NN cord-015021-pol2qm74 1878 16 , , , cord-015021-pol2qm74 1878 17 share share VB cord-015021-pol2qm74 1878 18 the the DT cord-015021-pol2qm74 1878 19 same same JJ cord-015021-pol2qm74 1878 20 anatomo anatomo NN cord-015021-pol2qm74 1878 21 - - HYPH cord-015021-pol2qm74 1878 22 pathological pathological JJ cord-015021-pol2qm74 1878 23 elemem elemem NNS cord-015021-pol2qm74 1878 24 : : : cord-015021-pol2qm74 1878 25 the the DT cord-015021-pol2qm74 1878 26 interstitial interstitial JJ cord-015021-pol2qm74 1878 27 edema edema NN cord-015021-pol2qm74 1878 28 , , , cord-015021-pol2qm74 1878 29 due due IN cord-015021-pol2qm74 1878 30 to to IN cord-015021-pol2qm74 1878 31 a a DT cord-015021-pol2qm74 1878 32 generalised generalised JJ cord-015021-pol2qm74 1878 33 endothelial endothelial JJ cord-015021-pol2qm74 1878 34 micro micro JJ cord-015021-pol2qm74 1878 35 circulatory circulatory JJ cord-015021-pol2qm74 1878 36 injury injury NN cord-015021-pol2qm74 1878 37 . . . cord-015021-pol2qm74 1879 1 This this DT cord-015021-pol2qm74 1879 2 alteration alteration NN cord-015021-pol2qm74 1879 3 , , , cord-015021-pol2qm74 1879 4 as as IN cord-015021-pol2qm74 1879 5 constantly constantly RB cord-015021-pol2qm74 1879 6 seen see VBN cord-015021-pol2qm74 1879 7 in in IN cord-015021-pol2qm74 1879 8 polytrauma polytrauma NN cord-015021-pol2qm74 1879 9 patients patient NNS cord-015021-pol2qm74 1879 10 , , , cord-015021-pol2qm74 1879 11 develops develop VBZ cord-015021-pol2qm74 1879 12 in in IN cord-015021-pol2qm74 1879 13 a a DT cord-015021-pol2qm74 1879 14 few few JJ cord-015021-pol2qm74 1879 15 hours hour NNS cord-015021-pol2qm74 1879 16 after after IN cord-015021-pol2qm74 1879 17 trauma trauma NN cord-015021-pol2qm74 1879 18 as as IN cord-015021-pol2qm74 1879 19 a a DT cord-015021-pol2qm74 1879 20 consequence consequence NN cord-015021-pol2qm74 1879 21 of of IN cord-015021-pol2qm74 1879 22 the the DT cord-015021-pol2qm74 1879 23 deregulation deregulation NN cord-015021-pol2qm74 1879 24 of of IN cord-015021-pol2qm74 1879 25 the the DT cord-015021-pol2qm74 1879 26 homoeostatic homoeostatic JJ cord-015021-pol2qm74 1879 27 and and CC cord-015021-pol2qm74 1879 28 immune immune JJ cord-015021-pol2qm74 1879 29 mechanisms mechanism NNS cord-015021-pol2qm74 1879 30 . . . cord-015021-pol2qm74 1880 1 In in IN cord-015021-pol2qm74 1880 2 fact fact NN cord-015021-pol2qm74 1880 3 the the DT cord-015021-pol2qm74 1880 4 overproduced overproduced JJ cord-015021-pol2qm74 1880 5 oxygen oxygen NN cord-015021-pol2qm74 1880 6 free free JJ cord-015021-pol2qm74 1880 7 radicals radical NNS cord-015021-pol2qm74 1880 8 and and CC cord-015021-pol2qm74 1880 9 r r NNP cord-015021-pol2qm74 1880 10 ~ ~ NFP cord-015021-pol2qm74 1880 11 ombinam ombinam NNP cord-015021-pol2qm74 1880 12 cytokines cytokine NNS cord-015021-pol2qm74 1880 13 ( ( -LRB- cord-015021-pol2qm74 1880 14 IL1,TNF IL1,TNF NNP cord-015021-pol2qm74 1880 15 ) ) -RRB- cord-015021-pol2qm74 1880 16 , , , cord-015021-pol2qm74 1880 17 together together RB cord-015021-pol2qm74 1880 18 with with IN cord-015021-pol2qm74 1880 19 the the DT cord-015021-pol2qm74 1880 20 complement complement JJ cord-015021-pol2qm74 1880 21 degradation degradation NN cord-015021-pol2qm74 1880 22 fragments fragment NNS cord-015021-pol2qm74 1880 23 , , , cord-015021-pol2qm74 1880 24 the the DT cord-015021-pol2qm74 1880 25 proteolytic proteolytic JJ cord-015021-pol2qm74 1880 26 enzymes enzyme NNS cord-015021-pol2qm74 1880 27 and and CC cord-015021-pol2qm74 1880 28 many many JJ cord-015021-pol2qm74 1880 29 other other JJ cord-015021-pol2qm74 1880 30 mediators mediator NNS cord-015021-pol2qm74 1880 31 are be VBP cord-015021-pol2qm74 1880 32 all all DT cord-015021-pol2qm74 1880 33 strongly strongly RB cord-015021-pol2qm74 1880 34 h h NN cord-015021-pol2qm74 1881 1 ~l ~l NNP cord-015021-pol2qm74 1881 2 ~ ~ NFP cord-015021-pol2qm74 1881 3 , , , cord-015021-pol2qm74 1881 4 _ _ NNP cord-015021-pol2qm74 1881 5 he -PRON- PRP cord-015021-pol2qm74 1881 6 e,,j e,,j NN cord-015021-pol2qm74 1881 7 , , , cord-015021-pol2qm74 1881 8 yheha yheha NNP cord-015021-pol2qm74 1881 9 ! ! . cord-015021-pol2qm74 1882 1 ceils ceils NNP cord-015021-pol2qm74 1882 2 . . . cord-015021-pol2qm74 1883 1 Our -PRON- PRP$ cord-015021-pol2qm74 1883 2 ~ ~ CD cord-015021-pol2qm74 1883 3 osect osect NN cord-015021-pol2qm74 1883 4 , , , cord-015021-pol2qm74 1883 5 atim~,-bnsed atim~,-bnse VBN cord-015021-pol2qm74 1883 6 on on IN cord-015021-pol2qm74 1883 7 examination examination NN cord-015021-pol2qm74 1883 8 of of IN cord-015021-pol2qm74 1883 9 autopsical autopsical JJ cord-015021-pol2qm74 1883 10 specimens specimen NNS cord-015021-pol2qm74 1883 11 from from IN cord-015021-pol2qm74 1883 12 85 85 CD cord-015021-pol2qm74 1883 13 polytraanm polytraanm NN cord-015021-pol2qm74 1883 14 patients patient NNS cord-015021-pol2qm74 1883 15 , , , cord-015021-pol2qm74 1883 16 showed show VBD cord-015021-pol2qm74 1883 17 that that IN cord-015021-pol2qm74 1883 18 such such JJ cord-015021-pol2qm74 1883 19 endothelial endothelial JJ cord-015021-pol2qm74 1883 20 damage damage NN cord-015021-pol2qm74 1883 21 , , , cord-015021-pol2qm74 1883 22 supporting support VBG cord-015021-pol2qm74 1883 23 the the DT cord-015021-pol2qm74 1883 24 interstitial interstitial JJ cord-015021-pol2qm74 1883 25 edema edema NN cord-015021-pol2qm74 1883 26 , , , cord-015021-pol2qm74 1883 27 is be VBZ cord-015021-pol2qm74 1883 28 widely widely RB cord-015021-pol2qm74 1883 29 and and CC cord-015021-pol2qm74 1883 30 simultaneensly simultaneensly RB cord-015021-pol2qm74 1883 31 distributed distribute VBN cord-015021-pol2qm74 1883 32 , , , cord-015021-pol2qm74 1883 33 ensues ensue VBZ cord-015021-pol2qm74 1883 34 shortly shortly RB cord-015021-pol2qm74 1883 35 aRer aRer NNP cord-015021-pol2qm74 1883 36 trauma trauma NN cord-015021-pol2qm74 1883 37 and and CC cord-015021-pol2qm74 1883 38 shows show VBZ cord-015021-pol2qm74 1883 39 its -PRON- PRP$ cord-015021-pol2qm74 1883 40 effects effect NNS cord-015021-pol2qm74 1883 41 in in IN cord-015021-pol2qm74 1883 42 different different JJ cord-015021-pol2qm74 1883 43 organs organ NNS cord-015021-pol2qm74 1883 44 at at IN cord-015021-pol2qm74 1883 45 different different JJ cord-015021-pol2qm74 1883 46 times time NNS cord-015021-pol2qm74 1883 47 , , , cord-015021-pol2qm74 1883 48 only only RB cord-015021-pol2qm74 1883 49 because because IN cord-015021-pol2qm74 1883 50 each each DT cord-015021-pol2qm74 1883 51 apparatus apparatus NN cord-015021-pol2qm74 1883 52 has have VBZ cord-015021-pol2qm74 1883 53 different different JJ cord-015021-pol2qm74 1883 54 fimctienal fimctienal JJ cord-015021-pol2qm74 1883 55 reserves reserve NNS cord-015021-pol2qm74 1883 56 : : : cord-015021-pol2qm74 1883 57 the the DT cord-015021-pol2qm74 1883 58 lung lung NN cord-015021-pol2qm74 1883 59 is be VBZ cord-015021-pol2qm74 1883 60 the the DT cord-015021-pol2qm74 1883 61 first first JJ cord-015021-pol2qm74 1883 62 organ organ NN cord-015021-pol2qm74 1883 63 to to TO cord-015021-pol2qm74 1883 64 fail fail VB cord-015021-pol2qm74 1883 65 just just RB cord-015021-pol2qm74 1883 66 because because IN cord-015021-pol2qm74 1883 67 its -PRON- PRP$ cord-015021-pol2qm74 1883 68 ah ah UH cord-015021-pol2qm74 1883 69 , , , cord-015021-pol2qm74 1883 70 celocapillary celocapillary NN cord-015021-pol2qm74 1883 71 membrane membrane NN cord-015021-pol2qm74 1883 72 is be VBZ cord-015021-pol2qm74 1883 73 one one CD cord-015021-pol2qm74 1883 74 of of IN cord-015021-pol2qm74 1883 75 the the DT cord-015021-pol2qm74 1883 76 most most RBS cord-015021-pol2qm74 1883 77 delicate delicate JJ cord-015021-pol2qm74 1883 78 bodily bodily JJ cord-015021-pol2qm74 1883 79 structure structure NN cord-015021-pol2qm74 1883 80 , , , cord-015021-pol2qm74 1883 81 and and CC cord-015021-pol2qm74 1883 82 its -PRON- PRP$ cord-015021-pol2qm74 1883 83 function function NN cord-015021-pol2qm74 1883 84 is be VBZ cord-015021-pol2qm74 1883 85 irroplace irroplace NNP cord-015021-pol2qm74 1883 86 ~ ~ NNP cord-015021-pol2qm74 1883 87 le le NNP cord-015021-pol2qm74 1883 88 . . . cord-015021-pol2qm74 1884 1 We -PRON- PRP cord-015021-pol2qm74 1884 2 think think VBP cord-015021-pol2qm74 1884 3 it -PRON- PRP cord-015021-pol2qm74 1884 4 will will MD cord-015021-pol2qm74 1884 5 be be VB cord-015021-pol2qm74 1884 6 of of IN cord-015021-pol2qm74 1884 7 a a DT cord-015021-pol2qm74 1884 8 great great JJ cord-015021-pol2qm74 1884 9 help help NN cord-015021-pol2qm74 1884 10 , , , cord-015021-pol2qm74 1884 11 in in IN cord-015021-pol2qm74 1884 12 planning plan VBG cord-015021-pol2qm74 1884 13 a a DT cord-015021-pol2qm74 1884 14 preventive preventive JJ cord-015021-pol2qm74 1884 15 therapy therapy NN cord-015021-pol2qm74 1884 16 , , , cord-015021-pol2qm74 1884 17 to to TO cord-015021-pol2qm74 1884 18 chose chose VB cord-015021-pol2qm74 1884 19 a a DT cord-015021-pol2qm74 1884 20 denomination denomination NN cord-015021-pol2qm74 1884 21 focusing focus VBG cord-015021-pol2qm74 1884 22 the the DT cord-015021-pol2qm74 1884 23 physician physician NN cord-015021-pol2qm74 1884 24 's 's POS cord-015021-pol2qm74 1884 25 attention attention NN cord-015021-pol2qm74 1884 26 on on IN cord-015021-pol2qm74 1884 27 the the DT cord-015021-pol2qm74 1884 28 earl earl NNP cord-015021-pol2qm74 1884 29 ) ) -RRB- cord-015021-pol2qm74 1884 30 " " `` cord-015021-pol2qm74 1884 31 generalized generalize VBD cord-015021-pol2qm74 1884 32 endothelial endothelial JJ cord-015021-pol2qm74 1884 33 injury injury NN cord-015021-pol2qm74 1884 34 and and CC cord-015021-pol2qm74 1884 35 its -PRON- PRP$ cord-015021-pol2qm74 1884 36 effects effect NNS cord-015021-pol2qm74 1884 37 , , , cord-015021-pol2qm74 1884 38 as as IN cord-015021-pol2qm74 1884 39 in in IN cord-015021-pol2qm74 1884 40 trauma trauma NN cord-015021-pol2qm74 1884 41 patients patient NNS cord-015021-pol2qm74 1884 42 it -PRON- PRP cord-015021-pol2qm74 1884 43 is be VBZ cord-015021-pol2qm74 1884 44 present present JJ cord-015021-pol2qm74 1885 1 -even -even VBN cord-015021-pol2qm74 1886 1 if if IN cord-015021-pol2qm74 1886 2 latenflysince latenflysince NNP cord-015021-pol2qm74 1886 3 the the DT cord-015021-pol2qm74 1886 4 first first JJ cord-015021-pol2qm74 1886 5 few few JJ cord-015021-pol2qm74 1886 6 hours hour NNS cord-015021-pol2qm74 1886 7 . . . cord-015021-pol2qm74 1887 1 We -PRON- PRP cord-015021-pol2qm74 1887 2 would would MD cord-015021-pol2qm74 1887 3 like like VB cord-015021-pol2qm74 1887 4 to to TO cord-015021-pol2qm74 1887 5 see see VB cord-015021-pol2qm74 1887 6 the the DT cord-015021-pol2qm74 1887 7 generalised generalised JJ cord-015021-pol2qm74 1887 8 endothelial endothelial JJ cord-015021-pol2qm74 1887 9 microcircolatory microcircolatory NNP cord-015021-pol2qm74 1887 10 injury injury NN cord-015021-pol2qm74 1887 11 properly properly RB cord-015021-pol2qm74 1887 12 highlighted highlight VBD cord-015021-pol2qm74 1887 13 when when WRB cord-015021-pol2qm74 1887 14 considering consider VBG cord-015021-pol2qm74 1887 15 the the DT cord-015021-pol2qm74 1887 16 best good JJS cord-015021-pol2qm74 1887 17 definition definition NN cord-015021-pol2qm74 1887 18 and and CC cord-015021-pol2qm74 1887 19 the the DT cord-015021-pol2qm74 1887 20 optimal optimal JJ cord-015021-pol2qm74 1887 21 nomenclature nomenclature NN cord-015021-pol2qm74 1887 22 for for IN cord-015021-pol2qm74 1887 23 the the DT cord-015021-pol2qm74 1887 24 post post JJ cord-015021-pol2qm74 1887 25 - - JJ cord-015021-pol2qm74 1887 26 traumatic traumatic JJ cord-015021-pol2qm74 1887 27 s3mdrome s3mdrome NNS cord-015021-pol2qm74 1887 28 . . . cord-015021-pol2qm74 1888 1 The the DT cord-015021-pol2qm74 1888 2 presence presence NN cord-015021-pol2qm74 1888 3 of of IN cord-015021-pol2qm74 1888 4 interleukin interleukin NN cord-015021-pol2qm74 1888 5 ( ( -LRB- cord-015021-pol2qm74 1888 6 IL)-8 IL)-8 NNP cord-015021-pol2qm74 1888 7 in in IN cord-015021-pol2qm74 1888 8 bronchoalveolar bronchoalveolar NNP cord-015021-pol2qm74 1888 9 lavage lavage NN cord-015021-pol2qm74 1888 10 fluid fluid NN cord-015021-pol2qm74 1888 11 of of IN cord-015021-pol2qm74 1888 12 critically critically RB cord-015021-pol2qm74 1888 13 ill ill JJ cord-015021-pol2qm74 1888 14 patients patient NNS cord-015021-pol2qm74 1888 15 correlates correlate VBZ cord-015021-pol2qm74 1888 16 clinically clinically RB cord-015021-pol2qm74 1888 17 with with IN cord-015021-pol2qm74 1888 18 the the DT cord-015021-pol2qm74 1888 19 development development NN cord-015021-pol2qm74 1888 20 of of IN cord-015021-pol2qm74 1888 21 the the DT cord-015021-pol2qm74 1888 22 adult adult NN cord-015021-pol2qm74 1888 23 respiratory respiratory JJ cord-015021-pol2qm74 1888 24 distress distress NN cord-015021-pol2qm74 1888 25 syndrome syndrome NN cord-015021-pol2qm74 1888 26 lARDS lARDS NNP cord-015021-pol2qm74 1888 27 ) ) -RRB- cord-015021-pol2qm74 1888 28 , , , cord-015021-pol2qm74 1888 29 and and CC cord-015021-pol2qm74 1888 30 inhibition inhibition NN cord-015021-pol2qm74 1888 31 of of IN cord-015021-pol2qm74 1888 32 IL-8 il-8 NN cord-015021-pol2qm74 1888 33 in in IN cord-015021-pol2qm74 1888 34 animal animal NN cord-015021-pol2qm74 1888 35 models model NNS cord-015021-pol2qm74 1888 36 can can MD cord-015021-pol2qm74 1888 37 attenuate attenuate VB cord-015021-pol2qm74 1888 38 lung lung NN cord-015021-pol2qm74 1888 39 injury injury NN cord-015021-pol2qm74 1888 40 . . . cord-015021-pol2qm74 1889 1 Collectively collectively RB cord-015021-pol2qm74 1889 2 , , , cord-015021-pol2qm74 1889 3 evidence evidence NN cord-015021-pol2qm74 1889 4 to to IN cord-015021-pol2qm74 1889 5 date date NN cord-015021-pol2qm74 1889 6 suggests suggest VBZ cord-015021-pol2qm74 1889 7 that that IN cord-015021-pol2qm74 1889 8 IL-8 IL-8 NNP cord-015021-pol2qm74 1889 9 attracts attract VBZ cord-015021-pol2qm74 1889 10 and and CC cord-015021-pol2qm74 1889 11 activates activate VBZ cord-015021-pol2qm74 1889 12 neutrophiis neutrophiis JJ cord-015021-pol2qm74 1889 13 ( ( -LRB- cord-015021-pol2qm74 1889 14 PMN PMN NNP cord-015021-pol2qm74 1889 15 ) ) -RRB- cord-015021-pol2qm74 1889 16 , , , cord-015021-pol2qm74 1889 17 which which WDT cord-015021-pol2qm74 1889 18 are be VBP cord-015021-pol2qm74 1889 19 then then RB cord-015021-pol2qm74 1889 20 responsible responsible JJ cord-015021-pol2qm74 1889 21 for for IN cord-015021-pol2qm74 1889 22 the the DT cord-015021-pol2qm74 1889 23 capillary capillary JJ cord-015021-pol2qm74 1889 24 leak leak NN cord-015021-pol2qm74 1889 25 of of IN cord-015021-pol2qm74 1889 26 ARDS ARDS NNP cord-015021-pol2qm74 1889 27 . . . cord-015021-pol2qm74 1890 1 However however RB cord-015021-pol2qm74 1890 2 , , , cord-015021-pol2qm74 1890 3 an an DT cord-015021-pol2qm74 1890 4 alternative alternative JJ cord-015021-pol2qm74 1890 5 explanation explanation NN cord-015021-pol2qm74 1890 6 is be VBZ cord-015021-pol2qm74 1890 7 that that IN cord-015021-pol2qm74 1890 8 IL-8 IL-8 NNP cord-015021-pol2qm74 1890 9 is be VBZ cord-015021-pol2qm74 1890 10 directly directly RB cord-015021-pol2qm74 1890 11 toxic toxic JJ cord-015021-pol2qm74 1890 12 to to IN cord-015021-pol2qm74 1890 13 the the DT cord-015021-pol2qm74 1890 14 endothelial endothelial JJ cord-015021-pol2qm74 1890 15 cell cell NN cord-015021-pol2qm74 1890 16 ( ( -LRB- cord-015021-pol2qm74 1890 17 EC EC NNP cord-015021-pol2qm74 1890 18 ) ) -RRB- cord-015021-pol2qm74 1890 19 . . . cord-015021-pol2qm74 1891 1 In in IN cord-015021-pol2qm74 1891 2 this this DT cord-015021-pol2qm74 1891 3 study study NN cord-015021-pol2qm74 1891 4 , , , cord-015021-pol2qm74 1891 5 we -PRON- PRP cord-015021-pol2qm74 1891 6 have have VBP cord-015021-pol2qm74 1891 7 hypothesized hypothesize VBN cord-015021-pol2qm74 1891 8 that that IN cord-015021-pol2qm74 1891 9 IL-8 IL-8 NNP cord-015021-pol2qm74 1891 10 can can MD cord-015021-pol2qm74 1891 11 disrupt disrupt VB cord-015021-pol2qm74 1891 12 endothelial endothelial JJ cord-015021-pol2qm74 1891 13 integrity integrity NN cord-015021-pol2qm74 1891 14 independent independent JJ cord-015021-pol2qm74 1891 15 of of IN cord-015021-pol2qm74 1891 16 PMN PMN NNP cord-015021-pol2qm74 1891 17 . . . cord-015021-pol2qm74 1892 1 Meth meth JJ cord-015021-pol2qm74 1892 2 ods od NNS cord-015021-pol2qm74 1892 3 : : : cord-015021-pol2qm74 1892 4 Human human JJ cord-015021-pol2qm74 1892 5 umbilical umbilical JJ cord-015021-pol2qm74 1892 6 vein vein NN cord-015021-pol2qm74 1892 7 ( ( -LRB- cord-015021-pol2qm74 1892 8 HUV HUV NNP cord-015021-pol2qm74 1892 9 ) ) -RRB- cord-015021-pol2qm74 1892 10 EC EC NNP cord-015021-pol2qm74 1892 11 monolayers monolayer NNS cord-015021-pol2qm74 1892 12 were be VBD cord-015021-pol2qm74 1892 13 cultured cultured JJ cord-015021-pol2qm74 1892 14 to to IN cord-015021-pol2qm74 1892 15 confluency confluency NN cord-015021-pol2qm74 1892 16 on on IN cord-015021-pol2qm74 1892 17 collagen collagen NN cord-015021-pol2qm74 1892 18 - - HYPH cord-015021-pol2qm74 1892 19 coated coat VBN cord-015021-pol2qm74 1892 20 micropore micropore NN cord-015021-pol2qm74 1892 21 filters filter NNS cord-015021-pol2qm74 1892 22 . . . cord-015021-pol2qm74 1893 1 To to TO cord-015021-pol2qm74 1893 2 assess assess VB cord-015021-pol2qm74 1893 3 EC EC NNP cord-015021-pol2qm74 1893 4 integrity integrity NN cord-015021-pol2qm74 1893 5 , , , cord-015021-pol2qm74 1893 6 1251.albumi 1251.albumi CD cord-015021-pol2qm74 1893 7 n n CD cord-015021-pol2qm74 1893 8 leak leak NN cord-015021-pol2qm74 1893 9 was be VBD cord-015021-pol2qm74 1893 10 quantitated quantitate VBN cord-015021-pol2qm74 1893 11 by by IN cord-015021-pol2qm74 1893 12 measuring measure VBG cord-015021-pol2qm74 1893 13 the the DT cord-015021-pol2qm74 1893 14 1251 1251 CD cord-015021-pol2qm74 1893 15 counts count NNS cord-015021-pol2qm74 1893 16 which which WDT cord-015021-pol2qm74 1893 17 crossed cross VBD cord-015021-pol2qm74 1893 18 the the DT cord-015021-pol2qm74 1893 19 monolayer monolayer NN cord-015021-pol2qm74 1893 20 , , , cord-015021-pol2qm74 1893 21 using use VBG cord-015021-pol2qm74 1893 22 a a DT cord-015021-pol2qm74 1893 23 gamma gamma NN cord-015021-pol2qm74 1893 24 counter counter NN cord-015021-pol2qm74 1893 25 . . . cord-015021-pol2qm74 1894 1 IL-8 IL-8 NNP cord-015021-pol2qm74 1895 1 ( ( -LRB- cord-015021-pol2qm74 1895 2 lpg lpg NNP cord-015021-pol2qm74 1895 3 / / SYM cord-015021-pol2qm74 1895 4 ml ml NNP cord-015021-pol2qm74 1895 5 ) ) -RRB- cord-015021-pol2qm74 1895 6 was be VBD cord-015021-pol2qm74 1895 7 incubated incubate VBN cord-015021-pol2qm74 1895 8 in in IN cord-015021-pol2qm74 1895 9 the the DT cord-015021-pol2qm74 1895 10 culture culture NN cord-015021-pol2qm74 1895 11 medium medium NN cord-015021-pol2qm74 1895 12 with with IN cord-015021-pol2qm74 1895 13 1251.albumi 1251.albumi CD cord-015021-pol2qm74 1895 14 n n NN cord-015021-pol2qm74 1895 15 for for IN cord-015021-pol2qm74 1895 16 21 21 CD cord-015021-pol2qm74 1895 17 hrs hrs NN cord-015021-pol2qm74 1895 18 . . . cord-015021-pol2qm74 1896 1 The the DT cord-015021-pol2qm74 1896 2 IL-8 IL-8 NNP cord-015021-pol2qm74 1896 3 dose dose NN cord-015021-pol2qm74 1896 4 was be VBD cord-015021-pol2qm74 1896 5 not not RB cord-015021-pol2qm74 1896 6 cytotoxic cytotoxic JJ cord-015021-pol2qm74 1896 7 . . . cord-015021-pol2qm74 1897 1 To to TO cord-015021-pol2qm74 1897 2 determine determine VB cord-015021-pol2qm74 1897 3 the the DT cord-015021-pol2qm74 1897 4 involvement involvement NN cord-015021-pol2qm74 1897 5 of of IN cord-015021-pol2qm74 1897 6 protein protein NN cord-015021-pol2qm74 1897 7 synthesis synthesis NN cord-015021-pol2qm74 1897 8 in in IN cord-015021-pol2qm74 1897 9 this this DT cord-015021-pol2qm74 1897 10 process process NN cord-015021-pol2qm74 1897 11 , , , cord-015021-pol2qm74 1897 12 selected select VBN cord-015021-pol2qm74 1897 13 monolayers monolayer NNS cord-015021-pol2qm74 1897 14 were be VBD cord-015021-pol2qm74 1897 15 pretreated pretreate VBN cord-015021-pol2qm74 1897 16 with with IN cord-015021-pol2qm74 1897 17 cycloheximide cycloheximide NN cord-015021-pol2qm74 1897 18 ( ( -LRB- cord-015021-pol2qm74 1897 19 CH CH NNP cord-015021-pol2qm74 1897 20 ) ) -RRB- cord-015021-pol2qm74 1897 21 prior prior RB cord-015021-pol2qm74 1897 22 to to IN cord-015021-pol2qm74 1897 23 11.-8 11.-8 CD cord-015021-pol2qm74 1897 24 addition addition NN cord-015021-pol2qm74 1897 25 . . . cord-015021-pol2qm74 1898 1 Statistical statistical JJ cord-015021-pol2qm74 1898 2 analysis analysis NN cord-015021-pol2qm74 1898 3 was be VBD cord-015021-pol2qm74 1898 4 performed perform VBN cord-015021-pol2qm74 1898 5 using use VBG cord-015021-pol2qm74 1898 6 ANOVMFisher ANOVMFisher NNP cord-015021-pol2qm74 1898 7 PLSD PLSD NNP cord-015021-pol2qm74 1898 8 . . . cord-015021-pol2qm74 1899 1 We -PRON- PRP cord-015021-pol2qm74 1899 2 have have VBP cord-015021-pol2qm74 1899 3 previously previously RB cord-015021-pol2qm74 1899 4 shown show VBN cord-015021-pol2qm74 1899 5 that that IN cord-015021-pol2qm74 1899 6 Platelet platelet NN cord-015021-pol2qm74 1899 7 Activating Activating NNP cord-015021-pol2qm74 1899 8 Factor Factor NNP cord-015021-pol2qm74 1899 9 ( ( -LRB- cord-015021-pol2qm74 1899 10 PAF PAF NNP cord-015021-pol2qm74 1899 11 ) ) -RRB- cord-015021-pol2qm74 1899 12 enhances enhance VBZ cord-015021-pol2qm74 1899 13 CDt8 cdt8 JJ cord-015021-pol2qm74 1899 14 expression expression NN cord-015021-pol2qm74 1899 15 and and CC cord-015021-pol2qm74 1899 16 primes prime VBZ cord-015021-pol2qm74 1899 17 PMN PMN NNP cord-015021-pol2qm74 1899 18 's 's POS cord-015021-pol2qm74 1899 19 for for IN cord-015021-pol2qm74 1899 20 subsequent subsequent JJ cord-015021-pol2qm74 1899 21 02generation 02generation NN cord-015021-pol2qm74 1899 22 . . . cord-015021-pol2qm74 1900 1 Both both DT cord-015021-pol2qm74 1900 2 are be VBP cord-015021-pol2qm74 1900 3 important important JJ cord-015021-pol2qm74 1900 4 steps step NNS cord-015021-pol2qm74 1900 5 in in IN cord-015021-pol2qm74 1900 6 PMN PMN NNP cord-015021-pol2qm74 1900 7 mediated mediate VBD cord-015021-pol2qm74 1900 8 injury injury NN cord-015021-pol2qm74 1900 9 and and CC cord-015021-pol2qm74 1900 10 are be VBP cord-015021-pol2qm74 1900 11 assumed assume VBN cord-015021-pol2qm74 1900 12 to to TO cord-015021-pol2qm74 1900 13 occur occur VB cord-015021-pol2qm74 1900 14 in in IN cord-015021-pol2qm74 1900 15 concert concert NN cord-015021-pol2qm74 1900 16 . . . cord-015021-pol2qm74 1901 1 Following follow VBG cord-015021-pol2qm74 1901 2 major major JJ cord-015021-pol2qm74 1901 3 trauma trauma NN cord-015021-pol2qm74 1901 4 non non JJ cord-015021-pol2qm74 1901 5 - - JJ cord-015021-pol2qm74 1901 6 specific specific JJ cord-015021-pol2qm74 1901 7 PMN PMN NNP cord-015021-pol2qm74 1901 8 inflammation inflammation NN cord-015021-pol2qm74 1901 9 is be VBZ cord-015021-pol2qm74 1901 10 activated activate VBN cord-015021-pol2qm74 1901 11 , , , cord-015021-pol2qm74 1901 12 however however RB cord-015021-pol2qm74 1901 13 , , , cord-015021-pol2qm74 1901 14 unbridled unbridled JJ cord-015021-pol2qm74 1901 15 systemic systemic JJ cord-015021-pol2qm74 1901 16 PMN pmn NN cord-015021-pol2qm74 1901 17 activity activity NN cord-015021-pol2qm74 1901 18 needs need VBZ cord-015021-pol2qm74 1901 19 to to TO cord-015021-pol2qm74 1901 20 be be VB cord-015021-pol2qm74 1901 21 minimized minimize VBN cord-015021-pol2qm74 1901 22 . . . cord-015021-pol2qm74 1902 1 Since since IN cord-015021-pol2qm74 1902 2 circulating circulate VBG cord-015021-pol2qm74 1902 3 catecholamines catecholamine NNS cord-015021-pol2qm74 1902 4 are be VBP cord-015021-pol2qm74 1902 5 high high JJ cord-015021-pol2qm74 1902 6 early early JJ cord-015021-pol2qm74 1902 7 post post JJ cord-015021-pol2qm74 1902 8 - - JJ cord-015021-pol2qm74 1902 9 injury injury NN cord-015021-pol2qm74 1902 10 , , , cord-015021-pol2qm74 1902 11 we -PRON- PRP cord-015021-pol2qm74 1902 12 hypothesised hypothesise VBD cord-015021-pol2qm74 1902 13 that that IN cord-015021-pol2qm74 1902 14 they -PRON- PRP cord-015021-pol2qm74 1902 15 downregu downregu RB cord-015021-pol2qm74 1902 16 / / SYM cord-015021-pol2qm74 1902 17 ate eat VBD cord-015021-pol2qm74 1902 18 CD CD NNP cord-015021-pol2qm74 1902 19 18 18 CD cord-015021-pol2qm74 1902 20 expression expression NN cord-015021-pol2qm74 1902 21 and and CC cord-015021-pol2qm74 1902 22 PMN PMN NNP cord-015021-pol2qm74 1902 23 priming prime VBG cord-015021-pol2qm74 1902 24 via via IN cord-015021-pol2qm74 1902 25 the the DT cord-015021-pol2qm74 1902 26 [ [ -LRB- cord-015021-pol2qm74 1902 27 3 3 CD cord-015021-pol2qm74 1902 28 adrenergic adrenergic NN cord-015021-pol2qm74 1902 29 signal signal NN cord-015021-pol2qm74 1902 30 transduction transduction NN cord-015021-pol2qm74 1902 31 pathway pathway NN cord-015021-pol2qm74 1902 32 . . . cord-015021-pol2qm74 1903 1 Methods method NNS cord-015021-pol2qm74 1903 2 : : : cord-015021-pol2qm74 1903 3 Normal normal JJ cord-015021-pol2qm74 1903 4 human human JJ cord-015021-pol2qm74 1903 5 PMNs pmn NNS cord-015021-pol2qm74 1903 6 were be VBD cord-015021-pol2qm74 1903 7 primed prime VBN cord-015021-pol2qm74 1903 8 with with IN cord-015021-pol2qm74 1903 9 PAF PAF NNP cord-015021-pol2qm74 1903 10 ( ( -LRB- cord-015021-pol2qm74 1903 11 10ng 10ng NN cord-015021-pol2qm74 1903 12 / / SYM cord-015021-pol2qm74 1903 13 ml ml NN cord-015021-pol2qm74 1903 14 for for IN cord-015021-pol2qm74 1903 15 5 5 CD cord-015021-pol2qm74 1903 16 min min NNP cord-015021-pol2qm74 1903 17 ) ) -RRB- cord-015021-pol2qm74 1903 18 or or CC cord-015021-pol2qm74 1903 19 pre pre VB cord-015021-pol2qm74 1903 20 - - VBN cord-015021-pol2qm74 1903 21 treated treat VBN cord-015021-pol2qm74 1903 22 with with IN cord-015021-pol2qm74 1903 23 10 10 CD cord-015021-pol2qm74 1903 24 - - SYM cord-015021-pol2qm74 1903 25 5 5 CD cord-015021-pol2qm74 1903 26 M M NNP cord-015021-pol2qm74 1903 27 of of IN cord-015021-pol2qm74 1903 28 Isoproterenol Isoproterenol NNP cord-015021-pol2qm74 1903 29 ( ( -LRB- cord-015021-pol2qm74 1903 30 I i NN cord-015021-pol2qm74 1903 31 ) ) -RRB- cord-015021-pol2qm74 1903 32 or or CC cord-015021-pol2qm74 1903 33 Forskoklin Forskoklin NNP cord-015021-pol2qm74 1903 34 ( ( -LRB- cord-015021-pol2qm74 1903 35 F F NNP cord-015021-pol2qm74 1903 36 ) ) -RRB- cord-015021-pol2qm74 1903 37 for for IN cord-015021-pol2qm74 1903 38 5 5 CD cord-015021-pol2qm74 1903 39 rain rain NN cord-015021-pol2qm74 1903 40 and and CC cord-015021-pol2qm74 1903 41 then then RB cord-015021-pol2qm74 1903 42 primed prime VBN cord-015021-pol2qm74 1903 43 with with IN cord-015021-pol2qm74 1903 44 PAF PAF NNP cord-015021-pol2qm74 1903 45 . . . cord-015021-pol2qm74 1904 1 CD18 CD18 NNP cord-015021-pol2qm74 1904 2 expression expression NN cord-015021-pol2qm74 1904 3 was be VBD cord-015021-pol2qm74 1904 4 measured measure VBN cord-015021-pol2qm74 1904 5 by by IN cord-015021-pol2qm74 1904 6 flow flow NN cord-015021-pol2qm74 1904 7 cytometry cytometry NN cord-015021-pol2qm74 1904 8 ( ( -LRB- cord-015021-pol2qm74 1904 9 Fig.l Fig.l NNP cord-015021-pol2qm74 1904 10 ) ) -RRB- cord-015021-pol2qm74 1904 11 and and CC cord-015021-pol2qm74 1904 12 02-generation 02-generation CD cord-015021-pol2qm74 1905 1 in in IN cord-015021-pol2qm74 1905 2 response response NN cord-015021-pol2qm74 1905 3 to to IN cord-015021-pol2qm74 1905 4 10-rM 10-rm CD cord-015021-pol2qm74 1905 5 fMLP fMLP NNS cord-015021-pol2qm74 1905 6 was be VBD cord-015021-pol2qm74 1905 7 determined determine VBN cord-015021-pol2qm74 1905 8 as as IN cord-015021-pol2qm74 1905 9 SOD SOD NNP cord-015021-pol2qm74 1905 10 inhibitable inhibitable JJ cord-015021-pol2qm74 1905 11 reduction reduction NN cord-015021-pol2qm74 1905 12 of of IN cord-015021-pol2qm74 1905 13 cytochrome cytochrome NN cord-015021-pol2qm74 1905 14 C c NN cord-015021-pol2qm74 1905 15 ( ( -LRB- cord-015021-pol2qm74 1905 16 Fig.2 Fig.2 NNP cord-015021-pol2qm74 1906 1 Holler Holler NNP cord-015021-pol2qm74 1907 1 * * NFP cord-015021-pol2qm74 1907 2 * * NFP cord-015021-pol2qm74 1907 3 and and CC cord-015021-pol2qm74 1907 4 Georg Georg NNP cord-015021-pol2qm74 1907 5 W. W. NNP cord-015021-pol2qm74 1907 6 Bornkamm Bornkamm NNP cord-015021-pol2qm74 1908 1 * * NFP cord-015021-pol2qm74 1908 2 Lymphocyte lymphocyte NN cord-015021-pol2qm74 1908 3 - - HYPH cord-015021-pol2qm74 1908 4 endothelial endothelial JJ cord-015021-pol2qm74 1908 5 interactions interaction NNS cord-015021-pol2qm74 1908 6 are be VBP cord-015021-pol2qm74 1908 7 crucial crucial JJ cord-015021-pol2qm74 1908 8 for for IN cord-015021-pol2qm74 1908 9 various various JJ cord-015021-pol2qm74 1908 10 immune immune JJ cord-015021-pol2qm74 1908 11 responses response NNS cord-015021-pol2qm74 1908 12 , , , cord-015021-pol2qm74 1908 13 including include VBG cord-015021-pol2qm74 1908 14 cytokine cytokine NN cord-015021-pol2qm74 1908 15 driven drive VBD cord-015021-pol2qm74 1908 16 inflammatory inflammatory JJ cord-015021-pol2qm74 1908 17 processes process NNS cord-015021-pol2qm74 1908 18 . . . cord-015021-pol2qm74 1909 1 Protein protein NN cord-015021-pol2qm74 1909 2 kinase kinase NN cord-015021-pol2qm74 1909 3 C C NNP cord-015021-pol2qm74 1909 4 ( ( -LRB- cord-015021-pol2qm74 1909 5 PKC)-inhibitors pkc)-inhibitor NNS cord-015021-pol2qm74 1909 6 on on IN cord-015021-pol2qm74 1909 7 the the DT cord-015021-pol2qm74 1909 8 other other JJ cord-015021-pol2qm74 1909 9 hand hand NN cord-015021-pol2qm74 1909 10 are be VBP cord-015021-pol2qm74 1909 11 discussed discuss VBN cord-015021-pol2qm74 1909 12 as as IN cord-015021-pol2qm74 1909 13 potential potential JJ cord-015021-pol2qm74 1909 14 cytokine cytokine NN cord-015021-pol2qm74 1909 15 antagonists antagonist NNS cord-015021-pol2qm74 1909 16 . . . cord-015021-pol2qm74 1910 1 In in IN cord-015021-pol2qm74 1910 2 the the DT cord-015021-pol2qm74 1910 3 present present JJ cord-015021-pol2qm74 1910 4 study study NN cord-015021-pol2qm74 1910 5 we -PRON- PRP cord-015021-pol2qm74 1910 6 investigated investigate VBD cord-015021-pol2qm74 1910 7 the the DT cord-015021-pol2qm74 1910 8 influence influence NN cord-015021-pol2qm74 1910 9 of of IN cord-015021-pol2qm74 1910 10 the the DT cord-015021-pol2qm74 1910 11 PKC PKC NNP cord-015021-pol2qm74 1910 12 - - HYPH cord-015021-pol2qm74 1910 13 inhibitor inhibitor NN cord-015021-pol2qm74 1910 14 GF109203X GF109203X NNP cord-015021-pol2qm74 1910 15 on on IN cord-015021-pol2qm74 1910 16 cytokine cytokine NN cord-015021-pol2qm74 1910 17 - - HYPH cord-015021-pol2qm74 1910 18 and and CC cord-015021-pol2qm74 1910 19 endotoxin endotoxin NN cord-015021-pol2qm74 1910 20 induced induce VBN cord-015021-pol2qm74 1910 21 expression expression NN cord-015021-pol2qm74 1910 22 of of IN cord-015021-pol2qm74 1910 23 intercellular intercellular JJ cord-015021-pol2qm74 1910 24 adhesion adhesion NN cord-015021-pol2qm74 1910 25 molecule molecule NN cord-015021-pol2qm74 1910 26 1 1 CD cord-015021-pol2qm74 1910 27 ( ( -LRB- cord-015021-pol2qm74 1910 28 ICAM-1 ICAM-1 NNP cord-015021-pol2qm74 1910 29 ) ) -RRB- cord-015021-pol2qm74 1910 30 and and CC cord-015021-pol2qm74 1910 31 on on IN cord-015021-pol2qm74 1910 32 adhesion adhesion NN cord-015021-pol2qm74 1910 33 of of IN cord-015021-pol2qm74 1910 34 lymphocytes lymphocyte NNS cord-015021-pol2qm74 1910 35 to to TO cord-015021-pol2qm74 1910 36 cytokine cytokine VB cord-015021-pol2qm74 1910 37 activated activate VBN cord-015021-pol2qm74 1910 38 endothelial endothelial JJ cord-015021-pol2qm74 1910 39 cells cell NNS cord-015021-pol2qm74 1910 40 . . . cord-015021-pol2qm74 1911 1 We -PRON- PRP cord-015021-pol2qm74 1911 2 found find VBD cord-015021-pol2qm74 1911 3 that that IN cord-015021-pol2qm74 1911 4 Tumor tumor NN cord-015021-pol2qm74 1911 5 necrosis necrosis NN cord-015021-pol2qm74 1911 6 factor factor NN cord-015021-pol2qm74 1911 7 alpha alpha NN cord-015021-pol2qm74 1912 1 ( ( -LRB- cord-015021-pol2qm74 1912 2 TNFo0-and tnfo0-and DT cord-015021-pol2qm74 1913 1 Lipopolysaccharide Lipopolysaccharide NNP cord-015021-pol2qm74 1913 2 ( ( -LRB- cord-015021-pol2qm74 1913 3 LPS)-induced lps)-induced JJ cord-015021-pol2qm74 1913 4 ICAM-1 icam-1 NN cord-015021-pol2qm74 1913 5 expression expression NN cord-015021-pol2qm74 1913 6 on on IN cord-015021-pol2qm74 1913 7 human human JJ cord-015021-pol2qm74 1913 8 endothelioma endothelioma NNS cord-015021-pol2qm74 1913 9 celts celts NNPS cord-015021-pol2qm74 1913 10 ( ( -LRB- cord-015021-pol2qm74 1913 11 EAhy926 EAhy926 NNP cord-015021-pol2qm74 1913 12 ) ) -RRB- cord-015021-pol2qm74 1913 13 were be VBD cord-015021-pol2qm74 1913 14 unaffected unaffected JJ cord-015021-pol2qm74 1913 15 by by IN cord-015021-pol2qm74 1913 16 the the DT cord-015021-pol2qm74 1913 17 PKC PKC NNP cord-015021-pol2qm74 1913 18 - - HYPH cord-015021-pol2qm74 1913 19 inhibitor inhibitor NN cord-015021-pol2qm74 1913 20 and and CC cord-015021-pol2qm74 1913 21 thus thus RB cord-015021-pol2qm74 1913 22 appeared appear VBD cord-015021-pol2qm74 1913 23 to to TO cord-015021-pol2qm74 1913 24 be be VB cord-015021-pol2qm74 1913 25 independent independent JJ cord-015021-pol2qm74 1913 26 of of IN cord-015021-pol2qm74 1913 27 PKC PKC NNP cord-015021-pol2qm74 1913 28 activation activation NN cord-015021-pol2qm74 1913 29 . . . cord-015021-pol2qm74 1914 1 In in IN cord-015021-pol2qm74 1914 2 contrast contrast NN cord-015021-pol2qm74 1914 3 , , , cord-015021-pol2qm74 1914 4 GF109203X GF109203X NNP cord-015021-pol2qm74 1914 5 significantly significantly RB cord-015021-pol2qm74 1914 6 reduced reduce VBN cord-015021-pol2qm74 1914 7 ICAM-1 icam-1 NN cord-015021-pol2qm74 1914 8 expression expression NN cord-015021-pol2qm74 1914 9 induced induce VBN cord-015021-pol2qm74 1914 10 by by IN cord-015021-pol2qm74 1914 11 Interferon Interferon NNP cord-015021-pol2qm74 1914 12 - - HYPH cord-015021-pol2qm74 1914 13 y y NNP cord-015021-pol2qm74 1914 14 ( ( -LRB- cord-015021-pol2qm74 1914 15 IFN- IFN- NNP cord-015021-pol2qm74 1914 16 ? ? . cord-015021-pol2qm74 1914 17 ) ) -RRB- cord-015021-pol2qm74 1915 1 and and CC cord-015021-pol2qm74 1915 2 Interleukin-1 Interleukin-1 NNP cord-015021-pol2qm74 1915 3 ( ( -LRB- cord-015021-pol2qm74 1915 4 IL-1 IL-1 NNP cord-015021-pol2qm74 1915 5 ) ) -RRB- cord-015021-pol2qm74 1915 6 . . . cord-015021-pol2qm74 1916 1 The the DT cord-015021-pol2qm74 1916 2 functional functional JJ cord-015021-pol2qm74 1916 3 relevance relevance NN cord-015021-pol2qm74 1916 4 of of IN cord-015021-pol2qm74 1916 5 these these DT cord-015021-pol2qm74 1916 6 findings finding NNS cord-015021-pol2qm74 1916 7 was be VBD cord-015021-pol2qm74 1916 8 evaluated evaluate VBN cord-015021-pol2qm74 1916 9 in in IN cord-015021-pol2qm74 1916 10 an an DT cord-015021-pol2qm74 1916 11 adhesion adhesion NN cord-015021-pol2qm74 1916 12 assay assay NN cord-015021-pol2qm74 1916 13 using use VBG cord-015021-pol2qm74 1916 14 human human JJ cord-015021-pol2qm74 1916 15 umbilical umbilical JJ cord-015021-pol2qm74 1916 16 vene vene NNP cord-015021-pol2qm74 1916 17 endothelial endothelial JJ cord-015021-pol2qm74 1916 18 cells cell NNS cord-015021-pol2qm74 1916 19 ( ( -LRB- cord-015021-pol2qm74 1916 20 HUVEC HUVEC NNP cord-015021-pol2qm74 1916 21 ) ) -RRB- cord-015021-pol2qm74 1916 22 and and CC cord-015021-pol2qm74 1916 23 peripheral peripheral JJ cord-015021-pol2qm74 1916 24 blood blood NN cord-015021-pol2qm74 1916 25 mononuclear mononuclear NN cord-015021-pol2qm74 1916 26 cells cell NNS cord-015021-pol2qm74 1916 27 ( ( -LRB- cord-015021-pol2qm74 1916 28 PBMC PBMC NNP cord-015021-pol2qm74 1916 29 ) ) -RRB- cord-015021-pol2qm74 1916 30 . . . cord-015021-pol2qm74 1917 1 In in IN cord-015021-pol2qm74 1917 2 fact fact NN cord-015021-pol2qm74 1917 3 , , , cord-015021-pol2qm74 1917 4 the the DT cord-015021-pol2qm74 1917 5 IFN- IFN- NNP cord-015021-pol2qm74 1917 6 ? ? . cord-015021-pol2qm74 1917 7 and and CC cord-015021-pol2qm74 1917 8 IL-1 IL-1 NNP cord-015021-pol2qm74 1917 9 induced induce VBD cord-015021-pol2qm74 1917 10 adhesion adhesion NN cord-015021-pol2qm74 1917 11 of of IN cord-015021-pol2qm74 1917 12 PBMC PBMC NNP cord-015021-pol2qm74 1917 13 to to TO cord-015021-pol2qm74 1917 14 cytokine cytokine VB cord-015021-pol2qm74 1917 15 treated treat VBN cord-015021-pol2qm74 1917 16 HUVEC HUVEC NNP cord-015021-pol2qm74 1917 17 could could MD cord-015021-pol2qm74 1917 18 be be VB cord-015021-pol2qm74 1917 19 downregulated downregulate VBN cord-015021-pol2qm74 1917 20 by by IN cord-015021-pol2qm74 1917 21 the the DT cord-015021-pol2qm74 1917 22 PKC PKC NNP cord-015021-pol2qm74 1917 23 - - HYPH cord-015021-pol2qm74 1917 24 inhibitor inhibitor NN cord-015021-pol2qm74 1917 25 , , , cord-015021-pol2qm74 1917 26 whereas whereas IN cord-015021-pol2qm74 1917 27 TNFc~-and TNFc~-and NNP cord-015021-pol2qm74 1917 28 LPS LPS NNP cord-015021-pol2qm74 1917 29 - - HYPH cord-015021-pol2qm74 1917 30 mediated mediate VBN cord-015021-pol2qm74 1917 31 adhesion adhesion NN cord-015021-pol2qm74 1917 32 was be VBD cord-015021-pol2qm74 1917 33 not not RB cord-015021-pol2qm74 1917 34 influenced influence VBN cord-015021-pol2qm74 1917 35 . . . cord-015021-pol2qm74 1918 1 Additionally additionally RB cord-015021-pol2qm74 1918 2 , , , cord-015021-pol2qm74 1918 3 the the DT cord-015021-pol2qm74 1918 4 IL-1 IL-1 NNP cord-015021-pol2qm74 1918 5 driven drive VBD cord-015021-pol2qm74 1918 6 ICAM-1 ICAM-1 JJR cord-015021-pol2qm74 1918 7 expression expression NN cord-015021-pol2qm74 1918 8 on on IN cord-015021-pol2qm74 1918 9 EAhy926 EAhy926 NNP cord-015021-pol2qm74 1918 10 cells cell NNS cord-015021-pol2qm74 1918 11 as as RB cord-015021-pol2qm74 1918 12 well well RB cord-015021-pol2qm74 1918 13 as as IN cord-015021-pol2qm74 1918 14 the the DT cord-015021-pol2qm74 1918 15 IL-1 IL-1 NNP cord-015021-pol2qm74 1918 16 induced induce VBD cord-015021-pol2qm74 1918 17 adhesion adhesion NN cord-015021-pol2qm74 1918 18 of of IN cord-015021-pol2qm74 1918 19 PBMC PBMC NNS cord-015021-pol2qm74 1918 20 to to IN cord-015021-pol2qm74 1918 21 HUVEC HUVEC NNP cord-015021-pol2qm74 1918 22 was be VBD cord-015021-pol2qm74 1918 23 found find VBN cord-015021-pol2qm74 1918 24 to to TO cord-015021-pol2qm74 1918 25 be be VB cord-015021-pol2qm74 1918 26 TNF tnf NN cord-015021-pol2qm74 1918 27 - - HYPH cord-015021-pol2qm74 1918 28 dependent dependent JJ cord-015021-pol2qm74 1918 29 , , , cord-015021-pol2qm74 1918 30 since since IN cord-015021-pol2qm74 1918 31 both both DT cord-015021-pol2qm74 1918 32 effects effect NNS cord-015021-pol2qm74 1918 33 could could MD cord-015021-pol2qm74 1918 34 be be VB cord-015021-pol2qm74 1918 35 inhibited inhibit VBN cord-015021-pol2qm74 1918 36 by by IN cord-015021-pol2qm74 1918 37 an an DT cord-015021-pol2qm74 1918 38 anti anti JJ cord-015021-pol2qm74 1918 39 - - JJ cord-015021-pol2qm74 1918 40 TNF tnf JJ cord-015021-pol2qm74 1918 41 monoclonal monoclonal JJ cord-015021-pol2qm74 1918 42 antibody antibody NN cord-015021-pol2qm74 1918 43 ( ( -LRB- cord-015021-pol2qm74 1918 44 195F 195f CD cord-015021-pol2qm74 1918 45 ) ) -RRB- cord-015021-pol2qm74 1918 46 . . . cord-015021-pol2qm74 1919 1 These these DT cord-015021-pol2qm74 1919 2 in in IN cord-015021-pol2qm74 1919 3 vitro vitro FW cord-015021-pol2qm74 1919 4 data data NN cord-015021-pol2qm74 1919 5 further far RBR cord-015021-pol2qm74 1919 6 support support VBP cord-015021-pol2qm74 1919 7 the the DT cord-015021-pol2qm74 1919 8 idea idea NN cord-015021-pol2qm74 1919 9 of of IN cord-015021-pol2qm74 1919 10 examining examine VBG cord-015021-pol2qm74 1919 11 PKC PKC NNP cord-015021-pol2qm74 1919 12 - - HYPH cord-015021-pol2qm74 1919 13 inhibitors inhibitor NNS cord-015021-pol2qm74 1919 14 , , , cord-015021-pol2qm74 1919 15 such such JJ cord-015021-pol2qm74 1919 16 as as IN cord-015021-pol2qm74 1919 17 GF109203X GF109203X NNP cord-015021-pol2qm74 1919 18 , , , cord-015021-pol2qm74 1919 19 for for IN cord-015021-pol2qm74 1919 20 their -PRON- PRP$ cord-015021-pol2qm74 1919 21 biological biological JJ cord-015021-pol2qm74 1919 22 relevance relevance NN cord-015021-pol2qm74 1919 23 in in IN cord-015021-pol2qm74 1919 24 cytokine cytokine JJ cord-015021-pol2qm74 1919 25 related related JJ cord-015021-pol2qm74 1919 26 dysregulations dysregulation NNS cord-015021-pol2qm74 1919 27 . . . cord-015021-pol2qm74 1920 1 Seiffge Seiffge NNP cord-015021-pol2qm74 1920 2 , , , cord-015021-pol2qm74 1920 3 D. D. NNP cord-015021-pol2qm74 1920 4 , , , cord-015021-pol2qm74 1920 5 Bissinger Bissinger NNP cord-015021-pol2qm74 1920 6 , , , cord-015021-pol2qm74 1920 7 T. T. NNP cord-015021-pol2qm74 1920 8 , , , cord-015021-pol2qm74 1920 9 Laux Laux NNP cord-015021-pol2qm74 1920 10 , , , cord-015021-pol2qm74 1920 11 V. V. NNP cord-015021-pol2qm74 1920 12 , , , cord-015021-pol2qm74 1920 13 During during IN cord-015021-pol2qm74 1920 14 inflammation inflammation NN cord-015021-pol2qm74 1920 15 there there EX cord-015021-pol2qm74 1920 16 are be VBP cord-015021-pol2qm74 1920 17 some some DT cord-015021-pol2qm74 1920 18 key key JJ cord-015021-pol2qm74 1920 19 processes process NNS cord-015021-pol2qm74 1920 20 , , , cord-015021-pol2qm74 1920 21 which which WDT cord-015021-pol2qm74 1920 22 occur occur VBP cord-015021-pol2qm74 1920 23 in in IN cord-015021-pol2qm74 1920 24 the the DT cord-015021-pol2qm74 1920 25 microcirculation microcirculation NN cord-015021-pol2qm74 1920 26 : : : cord-015021-pol2qm74 1921 1 The the DT cord-015021-pol2qm74 1921 2 release release NN cord-015021-pol2qm74 1921 3 of of IN cord-015021-pol2qm74 1921 4 mediators mediator NNS cord-015021-pol2qm74 1921 5 from from IN cord-015021-pol2qm74 1921 6 various various JJ cord-015021-pol2qm74 1921 7 cell cell NN cord-015021-pol2qm74 1921 8 types type NNS cord-015021-pol2qm74 1921 9 , , , cord-015021-pol2qm74 1921 10 the the DT cord-015021-pol2qm74 1921 11 migration migration NN cord-015021-pol2qm74 1921 12 of of IN cord-015021-pol2qm74 1921 13 inflammatory inflammatory JJ cord-015021-pol2qm74 1921 14 cells cell NNS cord-015021-pol2qm74 1921 15 towards towards IN cord-015021-pol2qm74 1921 16 a a DT cord-015021-pol2qm74 1921 17 chemotactic chemotactic JJ cord-015021-pol2qm74 1921 18 stimulus stimulus NN cord-015021-pol2qm74 1921 19 in in IN cord-015021-pol2qm74 1921 20 the the DT cord-015021-pol2qm74 1921 21 tissue tissue NN cord-015021-pol2qm74 1921 22 , , , cord-015021-pol2qm74 1921 23 the the DT cord-015021-pol2qm74 1921 24 expression expression NN cord-015021-pol2qm74 1921 25 of of IN cord-015021-pol2qm74 1921 26 adhesion adhesion NN cord-015021-pol2qm74 1921 27 molecules molecule NNS cord-015021-pol2qm74 1921 28 on on IN cord-015021-pol2qm74 1921 29 different different JJ cord-015021-pol2qm74 1921 30 cells cell NNS cord-015021-pol2qm74 1921 31 , , , cord-015021-pol2qm74 1921 32 and and CC cord-015021-pol2qm74 1921 33 the the DT cord-015021-pol2qm74 1921 34 extravasation extravasation NN cord-015021-pol2qm74 1921 35 of of IN cord-015021-pol2qm74 1921 36 plasma plasma NN cord-015021-pol2qm74 1921 37 proteins protein NNS cord-015021-pol2qm74 1921 38 . . . cord-015021-pol2qm74 1922 1 The the DT cord-015021-pol2qm74 1922 2 aim aim NN cord-015021-pol2qm74 1922 3 of of IN cord-015021-pol2qm74 1922 4 the the DT cord-015021-pol2qm74 1922 5 present present JJ cord-015021-pol2qm74 1922 6 study study NN cord-015021-pol2qm74 1922 7 was be VBD cord-015021-pol2qm74 1922 8 to to TO cord-015021-pol2qm74 1922 9 elucidate elucidate VB cord-015021-pol2qm74 1922 10 the the DT cord-015021-pol2qm74 1922 11 mediator mediator NN cord-015021-pol2qm74 1922 12 induced induce VBN cord-015021-pol2qm74 1922 13 interaction interaction NN cord-015021-pol2qm74 1922 14 of of IN cord-015021-pol2qm74 1922 15 leukocyte leukocyte NN cord-015021-pol2qm74 1922 16 adhesion adhesion NN cord-015021-pol2qm74 1922 17 and and CC cord-015021-pol2qm74 1922 18 plasma plasma NN cord-015021-pol2qm74 1922 19 leakage leakage NN cord-015021-pol2qm74 1922 20 in in IN cord-015021-pol2qm74 1922 21 postcapillary postcapillary NNP cord-015021-pol2qm74 1922 22 venules venule NNS cord-015021-pol2qm74 1922 23 . . . cord-015021-pol2qm74 1923 1 Using use VBG cord-015021-pol2qm74 1923 2 an an DT cord-015021-pol2qm74 1923 3 analogous analogous JJ cord-015021-pol2qm74 1923 4 video video NN cord-015021-pol2qm74 1923 5 - - HYPH cord-015021-pol2qm74 1923 6 image image NN cord-015021-pol2qm74 1923 7 analysing analysing NN cord-015021-pol2qm74 1923 8 system system NN cord-015021-pol2qm74 1923 9 we -PRON- PRP cord-015021-pol2qm74 1923 10 have have VBP cord-015021-pol2qm74 1923 11 studied study VBN cord-015021-pol2qm74 1923 12 the the DT cord-015021-pol2qm74 1923 13 effect effect NN cord-015021-pol2qm74 1923 14 of of IN cord-015021-pol2qm74 1923 15 different different JJ cord-015021-pol2qm74 1923 16 mediators mediator NNS cord-015021-pol2qm74 1923 17 on on IN cord-015021-pol2qm74 1923 18 leukocyte leukocyte NN cord-015021-pol2qm74 1923 19 adhesion adhesion NN cord-015021-pol2qm74 1923 20 and and CC cord-015021-pol2qm74 1923 21 macromolecular macromolecular JJ cord-015021-pol2qm74 1923 22 permeability permeability NN cord-015021-pol2qm74 1923 23 in in IN cord-015021-pol2qm74 1923 24 the the DT cord-015021-pol2qm74 1923 25 mesentery mesentery NN cord-015021-pol2qm74 1923 26 of of IN cord-015021-pol2qm74 1923 27 the the DT cord-015021-pol2qm74 1923 28 rat rat NN cord-015021-pol2qm74 1923 29 . . . cord-015021-pol2qm74 1924 1 The the DT cord-015021-pol2qm74 1924 2 increase increase NN cord-015021-pol2qm74 1924 3 in in IN cord-015021-pol2qm74 1924 4 permeability permeability NN cord-015021-pol2qm74 1924 5 was be VBD cord-015021-pol2qm74 1924 6 measured measure VBN cord-015021-pol2qm74 1924 7 as as IN cord-015021-pol2qm74 1924 8 changes change NNS cord-015021-pol2qm74 1924 9 in in IN cord-015021-pol2qm74 1924 10 optical optical JJ cord-015021-pol2qm74 1924 11 density density NN cord-015021-pol2qm74 1924 12 . . . cord-015021-pol2qm74 1925 1 We -PRON- PRP cord-015021-pol2qm74 1925 2 found find VBD cord-015021-pol2qm74 1925 3 that that IN cord-015021-pol2qm74 1925 4 topical topical JJ cord-015021-pol2qm74 1925 5 administration administration NN cord-015021-pol2qm74 1925 6 of of IN cord-015021-pol2qm74 1925 7 leneotriene leneotriene NNP cord-015021-pol2qm74 1925 8 B B NNP cord-015021-pol2qm74 1925 9 4 4 CD cord-015021-pol2qm74 1926 1 ( ( -LRB- cord-015021-pol2qm74 1926 2 LTB4 LTB4 NNP cord-015021-pol2qm74 1926 3 , , , cord-015021-pol2qm74 1926 4 5x10 5x10 CD cord-015021-pol2qm74 1926 5 " " `` cord-015021-pol2qm74 1926 6 6 6 CD cord-015021-pol2qm74 1926 7 tool tool NN cord-015021-pol2qm74 1926 8 / / SYM cord-015021-pol2qm74 1926 9 l l NN cord-015021-pol2qm74 1926 10 ) ) -RRB- cord-015021-pol2qm74 1926 11 or or CC cord-015021-pol2qm74 1926 12 intravenous intravenous JJ cord-015021-pol2qm74 1926 13 injection injection NN cord-015021-pol2qm74 1926 14 of of IN cord-015021-pol2qm74 1926 15 interleuldn-2 interleuldn-2 NNP cord-015021-pol2qm74 1927 1 ( ( -LRB- cord-015021-pol2qm74 1927 2 IL-2 IL-2 NNP cord-015021-pol2qm74 1927 3 , , , cord-015021-pol2qm74 1927 4 5 5 CD cord-015021-pol2qm74 1927 5 - - SYM cord-015021-pol2qm74 1927 6 106 106 CD cord-015021-pol2qm74 1927 7 IU IU NNP cord-015021-pol2qm74 1927 8 / / SYM cord-015021-pol2qm74 1927 9 kg kg NN cord-015021-pol2qm74 1927 10 b.w b.w NNP cord-015021-pol2qm74 1927 11 . . . cord-015021-pol2qm74 1928 1 ) ) -RRB- cord-015021-pol2qm74 1928 2 and and CC cord-015021-pol2qm74 1928 3 lipopolysaccharide lipopolysaccharide NN cord-015021-pol2qm74 1928 4 ( ( -LRB- cord-015021-pol2qm74 1928 5 LPS LPS NNP cord-015021-pol2qm74 1928 6 , , , cord-015021-pol2qm74 1928 7 15 15 CD cord-015021-pol2qm74 1928 8 mg mg NNP cord-015021-pol2qm74 1928 9 / / SYM cord-015021-pol2qm74 1928 10 kg kg NNP cord-015021-pol2qm74 1928 11 b.w b.w NNP cord-015021-pol2qm74 1928 12 . . NNP cord-015021-pol2qm74 1928 13 ) ) -RRB- cord-015021-pol2qm74 1928 14 resulted result VBD cord-015021-pol2qm74 1928 15 in in IN cord-015021-pol2qm74 1928 16 a a DT cord-015021-pol2qm74 1928 17 significant significant JJ cord-015021-pol2qm74 1928 18 extravasation extravasation NN cord-015021-pol2qm74 1928 19 of of IN cord-015021-pol2qm74 1928 20 FITC FITC NNP cord-015021-pol2qm74 1928 21 - - HYPH cord-015021-pol2qm74 1928 22 labelled label VBN cord-015021-pol2qm74 1928 23 rat rat NN cord-015021-pol2qm74 1928 24 serum serum NN cord-015021-pol2qm74 1928 25 albumin albumin NN cord-015021-pol2qm74 1928 26 ( ( -LRB- cord-015021-pol2qm74 1928 27 FITC FITC NNP cord-015021-pol2qm74 1928 28 - - HYPH cord-015021-pol2qm74 1928 29 RSA RSA NNP cord-015021-pol2qm74 1928 30 ) ) -RRB- cord-015021-pol2qm74 1928 31 in in IN cord-015021-pol2qm74 1928 32 venules venule NNS cord-015021-pol2qm74 1928 33 but but CC cord-015021-pol2qm74 1928 34 not not RB cord-015021-pol2qm74 1928 35 in in IN cord-015021-pol2qm74 1928 36 arterioles arteriole NNS cord-015021-pol2qm74 1928 37 . . . cord-015021-pol2qm74 1929 1 We -PRON- PRP cord-015021-pol2qm74 1929 2 could could MD cord-015021-pol2qm74 1929 3 correlate correlate VB cord-015021-pol2qm74 1929 4 the the DT cord-015021-pol2qm74 1929 5 changes change NNS cord-015021-pol2qm74 1929 6 in in IN cord-015021-pol2qm74 1929 7 vascular vascular JJ cord-015021-pol2qm74 1929 8 permeability permeability NN cord-015021-pol2qm74 1929 9 with with IN cord-015021-pol2qm74 1929 10 a a DT cord-015021-pol2qm74 1929 11 locally locally RB cord-015021-pol2qm74 1929 12 increased increase VBN cord-015021-pol2qm74 1929 13 number number NN cord-015021-pol2qm74 1929 14 of of IN cord-015021-pol2qm74 1929 15 rolling roll VBG cord-015021-pol2qm74 1929 16 and and CC cord-015021-pol2qm74 1929 17 sticking stick VBG cord-015021-pol2qm74 1929 18 leukocytes leukocyte NNS cord-015021-pol2qm74 1929 19 in in IN cord-015021-pol2qm74 1929 20 venules venule NNS cord-015021-pol2qm74 1929 21 . . . cord-015021-pol2qm74 1930 1 Both both DT cord-015021-pol2qm74 1930 2 effects effect NNS cord-015021-pol2qm74 1930 3 were be VBD cord-015021-pol2qm74 1930 4 dose dose VBN cord-015021-pol2qm74 1930 5 dependently dependently RB cord-015021-pol2qm74 1930 6 inhibited inhibit VBN cord-015021-pol2qm74 1930 7 by by IN cord-015021-pol2qm74 1930 8 different different JJ cord-015021-pol2qm74 1930 9 drugs drug NNS cord-015021-pol2qm74 1930 10 . . . cord-015021-pol2qm74 1931 1 Pentoxlfylline Pentoxlfylline NNP cord-015021-pol2qm74 1931 2 inhibits inhibit VBZ cord-015021-pol2qm74 1931 3 LPS LPS NNP cord-015021-pol2qm74 1931 4 - - HYPH cord-015021-pol2qm74 1931 5 indueed indueed NN cord-015021-pol2qm74 1931 6 FITC FITC NNP cord-015021-pol2qm74 1931 7 - - HYPH cord-015021-pol2qm74 1931 8 RSA rsa NN cord-015021-pol2qm74 1931 9 extravasation extravasation NN cord-015021-pol2qm74 1931 10 and and CC cord-015021-pol2qm74 1931 11 leukocyte leukocyte NN cord-015021-pol2qm74 1931 12 adhesion adhesion NN cord-015021-pol2qm74 1931 13 at at IN cord-015021-pol2qm74 1931 14 a a DT cord-015021-pol2qm74 1931 15 dose dose NN cord-015021-pol2qm74 1931 16 of of IN cord-015021-pol2qm74 1931 17 3 3 CD cord-015021-pol2qm74 1931 18 mg mg NNP cord-015021-pol2qm74 1931 19 / / SYM cord-015021-pol2qm74 1931 20 kg kg NNP cord-015021-pol2qm74 1931 21 b.w b.w NNP cord-015021-pol2qm74 1931 22 . . . cord-015021-pol2qm74 1932 1 , , , cord-015021-pol2qm74 1932 2 superoxid superoxid NN cord-015021-pol2qm74 1932 3 - - HYPH cord-015021-pol2qm74 1932 4 dismutase dismutase NN cord-015021-pol2qm74 1932 5 ( ( -LRB- cord-015021-pol2qm74 1932 6 SOD SOD NNP cord-015021-pol2qm74 1932 7 , , , cord-015021-pol2qm74 1932 8 10.000 10.000 CD cord-015021-pol2qm74 1932 9 IU IU NNP cord-015021-pol2qm74 1932 10 / / SYM cord-015021-pol2qm74 1932 11 kg kg NN cord-015021-pol2qm74 1932 12 b.w b.w NNP cord-015021-pol2qm74 1932 13 . . NNP cord-015021-pol2qm74 1932 14 ) ) -RRB- cord-015021-pol2qm74 1932 15 was be VBD cord-015021-pol2qm74 1932 16 able able JJ cord-015021-pol2qm74 1932 17 to to TO cord-015021-pol2qm74 1932 18 decrease decrease VB cord-015021-pol2qm74 1932 19 the the DT cord-015021-pol2qm74 1932 20 LTB LTB NNP cord-015021-pol2qm74 1932 21 4 4 CD cord-015021-pol2qm74 1932 22 effect effect NN cord-015021-pol2qm74 1932 23 , , , cord-015021-pol2qm74 1932 24 and and CC cord-015021-pol2qm74 1932 25 the the DT cord-015021-pol2qm74 1932 26 immuumodulating immuumodulate VBG cord-015021-pol2qm74 1932 27 drug drug NNP cord-015021-pol2qm74 1932 28 leflunomide leflunomide NNP cord-015021-pol2qm74 1932 29 ( ( -LRB- cord-015021-pol2qm74 1932 30 HWA HWA NNP cord-015021-pol2qm74 1932 31 486 486 CD cord-015021-pol2qm74 1932 32 ) ) -RRB- cord-015021-pol2qm74 1932 33 exerted exert VBD cord-015021-pol2qm74 1932 34 inhibitory inhibitory JJ cord-015021-pol2qm74 1932 35 effects effect NNS cord-015021-pol2qm74 1932 36 on on IN cord-015021-pol2qm74 1932 37 IL-2-induced il-2-induced CD cord-015021-pol2qm74 1932 38 permeability permeability NN cord-015021-pol2qm74 1932 39 at at IN cord-015021-pol2qm74 1932 40 a a DT cord-015021-pol2qm74 1932 41 dose dose NN cord-015021-pol2qm74 1932 42 of of IN cord-015021-pol2qm74 1932 43 3 3 CD cord-015021-pol2qm74 1932 44 mg mg NNP cord-015021-pol2qm74 1932 45 / / SYM cord-015021-pol2qm74 1932 46 kg kg NNP cord-015021-pol2qm74 1932 47 b.w.i.v b.w.i.v NNP cord-015021-pol2qm74 1932 48 . . . cord-015021-pol2qm74 1933 1 The the DT cord-015021-pol2qm74 1933 2 obtained obtain VBN cord-015021-pol2qm74 1933 3 results result NNS cord-015021-pol2qm74 1933 4 demonstrate demonstrate VBP cord-015021-pol2qm74 1933 5 that that IN cord-015021-pol2qm74 1933 6 LPS LPS NNP cord-015021-pol2qm74 1933 7 , , , cord-015021-pol2qm74 1933 8 LTB LTB NNP cord-015021-pol2qm74 1933 9 4 4 CD cord-015021-pol2qm74 1933 10 or or CC cord-015021-pol2qm74 1933 11 IL-2 IL-2 NNP cord-015021-pol2qm74 1933 12 induced induce VBD cord-015021-pol2qm74 1933 13 extravasation extravasation NN cord-015021-pol2qm74 1933 14 of of IN cord-015021-pol2qm74 1933 15 FITC FITC NNP cord-015021-pol2qm74 1933 16 - - HYPH cord-015021-pol2qm74 1933 17 RSA RSA NNP cord-015021-pol2qm74 1933 18 is be VBZ cord-015021-pol2qm74 1933 19 mediated mediate VBN cord-015021-pol2qm74 1933 20 by by IN cord-015021-pol2qm74 1933 21 activated activate VBN cord-015021-pol2qm74 1933 22 leukocytes leukocyte NNS cord-015021-pol2qm74 1933 23 and and CC cord-015021-pol2qm74 1933 24 can can MD cord-015021-pol2qm74 1933 25 be be VB cord-015021-pol2qm74 1933 26 deminished deminishe VBN cord-015021-pol2qm74 1933 27 following follow VBG cord-015021-pol2qm74 1933 28 administration administration NN cord-015021-pol2qm74 1933 29 of of IN cord-015021-pol2qm74 1933 30 different different JJ cord-015021-pol2qm74 1933 31 drugs drug NNS cord-015021-pol2qm74 1933 32 . . . cord-015021-pol2qm74 1934 1 Platelet platelet NN cord-015021-pol2qm74 1934 2 - - HYPH cord-015021-pol2qm74 1934 3 endothelial endothelial JJ cord-015021-pol2qm74 1934 4 cell cell NN cord-015021-pol2qm74 1934 5 adhesion adhesion NN cord-015021-pol2qm74 1934 6 molecule- molecule- NN cord-015021-pol2qm74 1935 1 i i PRP cord-015021-pol2qm74 1935 2 ( ( -LRB- cord-015021-pol2qm74 1935 3 PECAM PECAM NNP cord-015021-pol2qm74 1935 4 - - HYPH cord-015021-pol2qm74 1935 5 I I NNP cord-015021-pol2qm74 1935 6 ) ) -RRB- cord-015021-pol2qm74 1935 7 , , , cord-015021-pol2qm74 1935 8 a a DT cord-015021-pol2qm74 1935 9 member member NN cord-015021-pol2qm74 1935 10 of of IN cord-015021-pol2qm74 1935 11 the the DT cord-015021-pol2qm74 1935 12 immunoglobulin immunoglobulin NN cord-015021-pol2qm74 1935 13 superfamily superfamily NN cord-015021-pol2qm74 1935 14 , , , cord-015021-pol2qm74 1935 15 is be VBZ cord-015021-pol2qm74 1935 16 constitutively constitutively RB cord-015021-pol2qm74 1935 17 expressed express VBN cord-015021-pol2qm74 1935 18 at at IN cord-015021-pol2qm74 1935 19 high high JJ cord-015021-pol2qm74 1935 20 levels level NNS cord-015021-pol2qm74 1935 21 on on IN cord-015021-pol2qm74 1935 22 the the DT cord-015021-pol2qm74 1935 23 endothelial endothelial JJ cord-015021-pol2qm74 1935 24 cell cell NN cord-015021-pol2qm74 1935 25 surface surface NN cord-015021-pol2qm74 1935 26 . . . cord-015021-pol2qm74 1936 1 In in IN cord-015021-pol2qm74 1936 2 vitro vitro FW cord-015021-pol2qm74 1936 3 data datum NNS cord-015021-pol2qm74 1936 4 have have VBP cord-015021-pol2qm74 1936 5 suggested suggest VBN cord-015021-pol2qm74 1936 6 that that IN cord-015021-pol2qm74 1936 7 PECAM PECAM NNP cord-015021-pol2qm74 1936 8 - - HYPH cord-015021-pol2qm74 1936 9 I -PRON- PRP cord-015021-pol2qm74 1936 10 functions function VBZ cord-015021-pol2qm74 1936 11 as as IN cord-015021-pol2qm74 1936 12 a a DT cord-015021-pol2qm74 1936 13 vascular vascular JJ cord-015021-pol2qm74 1936 14 adhesion adhesion NN cord-015021-pol2qm74 1936 15 molecule molecule NN cord-015021-pol2qm74 1936 16 , , , cord-015021-pol2qm74 1936 17 specifically specifically RB cord-015021-pol2qm74 1936 18 in in IN cord-015021-pol2qm74 1936 19 neutrophil neutrophil NN cord-015021-pol2qm74 1936 20 transmigration transmigration NN cord-015021-pol2qm74 1936 21 across across IN cord-015021-pol2qm74 1936 22 the the DT cord-015021-pol2qm74 1936 23 endothelium endothelium NN cord-015021-pol2qm74 1936 24 . . . cord-015021-pol2qm74 1937 1 This this DT cord-015021-pol2qm74 1937 2 current current JJ cord-015021-pol2qm74 1937 3 work work NN cord-015021-pol2qm74 1937 4 is be VBZ cord-015021-pol2qm74 1937 5 the the DT cord-015021-pol2qm74 1937 6 first first RB cord-015021-pol2qm74 1937 7 demonstrating demonstrate VBG cord-015021-pol2qm74 1937 8 the the DT cord-015021-pol2qm74 1937 9 in in IN cord-015021-pol2qm74 1937 10 vivo vivo NN cord-015021-pol2qm74 1937 11 role role NN cord-015021-pol2qm74 1937 12 of of IN cord-015021-pol2qm74 1937 13 PECAM-1 PECAM-1 NNP cord-015021-pol2qm74 1937 14 in in IN cord-015021-pol2qm74 1937 15 neutrophil neutrophil NN cord-015021-pol2qm74 1937 16 migration migration NN cord-015021-pol2qm74 1937 17 . . . cord-015021-pol2qm74 1938 1 Blocking block VBG cord-015021-pol2qm74 1938 2 antibodies antibody NNS cord-015021-pol2qm74 1938 3 to to IN cord-015021-pol2qm74 1938 4 human human JJ cord-015021-pol2qm74 1938 5 PECAM-1 PECAM-1 NNP cord-015021-pol2qm74 1938 6 , , , cord-015021-pol2qm74 1938 7 in in IN cord-015021-pol2qm74 1938 8 which which WDT cord-015021-pol2qm74 1938 9 the the DT cord-015021-pol2qm74 1938 10 antibodies antibody NNS cord-015021-pol2qm74 1938 11 are be VBP cord-015021-pol2qm74 1938 12 crossreactive crossreactive JJ cord-015021-pol2qm74 1938 13 with with IN cord-015021-pol2qm74 1938 14 rat rat NN cord-015021-pol2qm74 1938 15 PECAM-1 PECAM-1 NNP cord-015021-pol2qm74 1938 16 , , , cord-015021-pol2qm74 1938 17 were be VBD cord-015021-pol2qm74 1938 18 able able JJ cord-015021-pol2qm74 1938 19 to to TO cord-015021-pol2qm74 1938 20 block block VB cord-015021-pol2qm74 1938 21 the the DT cord-015021-pol2qm74 1938 22 movement movement NN cord-015021-pol2qm74 1938 23 of of IN cord-015021-pol2qm74 1938 24 neutrophils neutrophil NNS cord-015021-pol2qm74 1938 25 into into IN cord-015021-pol2qm74 1938 26 the the DT cord-015021-pol2qm74 1938 27 rat rat NN cord-015021-pol2qm74 1938 28 lungs lung NNS cord-015021-pol2qm74 1938 29 after after IN cord-015021-pol2qm74 1938 30 IgG IgG NNP cord-015021-pol2qm74 1938 31 immune immune VBP cord-015021-pol2qm74 1938 32 complex complex JJ cord-015021-pol2qm74 1938 33 deposition deposition NN cord-015021-pol2qm74 1938 34 . . . cord-015021-pol2qm74 1939 1 Furthermore furthermore RB cord-015021-pol2qm74 1939 2 , , , cord-015021-pol2qm74 1939 3 when when WRB cord-015021-pol2qm74 1939 4 human human JJ cord-015021-pol2qm74 1939 5 foreskin foreskin NN cord-015021-pol2qm74 1939 6 was be VBD cord-015021-pol2qm74 1939 7 transplanted transplant VBN cord-015021-pol2qm74 1939 8 into into IN cord-015021-pol2qm74 1939 9 mice mouse NNS cord-015021-pol2qm74 1939 10 with with IN cord-015021-pol2qm74 1939 11 severe severe JJ cord-015021-pol2qm74 1939 12 combined combine VBN cord-015021-pol2qm74 1939 13 immunodeficiency immunodeficiency NN cord-015021-pol2qm74 1939 14 and and CC cord-015021-pol2qm74 1939 15 the the DT cord-015021-pol2qm74 1939 16 site site NN cord-015021-pol2qm74 1939 17 injected inject VBN cord-015021-pol2qm74 1939 18 with with IN cord-015021-pol2qm74 1939 19 TNF TNF NNP cord-015021-pol2qm74 1939 20 - - HYPH cord-015021-pol2qm74 1939 21 alpha alpha NNP cord-015021-pol2qm74 1939 22 , , , cord-015021-pol2qm74 1939 23 anti anti JJ cord-015021-pol2qm74 1939 24 - - JJ cord-015021-pol2qm74 1939 25 PECAM PECAM NNP cord-015021-pol2qm74 1939 26 - - HYPH cord-015021-pol2qm74 1939 27 I -PRON- PRP cord-015021-pol2qm74 1939 28 blocked block VBD cord-015021-pol2qm74 1939 29 neutrophil neutrophil NN cord-015021-pol2qm74 1939 30 emigration emigration NN cord-015021-pol2qm74 1939 31 into into IN cord-015021-pol2qm74 1939 32 the the DT cord-015021-pol2qm74 1939 33 dermal dermal JJ cord-015021-pol2qm74 1939 34 interstitium interstitium NN cord-015021-pol2qm74 1939 35 . . . cord-015021-pol2qm74 1940 1 It -PRON- PRP cord-015021-pol2qm74 1940 2 has have VBZ cord-015021-pol2qm74 1940 3 already already RB cord-015021-pol2qm74 1940 4 been be VBN cord-015021-pol2qm74 1940 5 established establish VBN cord-015021-pol2qm74 1940 6 that that IN cord-015021-pol2qm74 1940 7 neutrophil neutrophil NN cord-015021-pol2qm74 1940 8 recruitment recruitment NN cord-015021-pol2qm74 1940 9 is be VBZ cord-015021-pol2qm74 1940 10 dependent dependent JJ cord-015021-pol2qm74 1940 11 upon upon IN cord-015021-pol2qm74 1940 12 selectin selectin NNP cord-015021-pol2qm74 1940 13 mediated mediate VBN cord-015021-pol2qm74 1940 14 rolling rolling NN cord-015021-pol2qm74 1940 15 , , , cord-015021-pol2qm74 1940 16 followed follow VBN cord-015021-pol2qm74 1940 17 by by IN cord-015021-pol2qm74 1940 18 firm firm JJ cord-015021-pol2qm74 1940 19 adherence adherence NN cord-015021-pol2qm74 1940 20 that that WDT cord-015021-pol2qm74 1940 21 is be VBZ cord-015021-pol2qm74 1940 22 ICAM-1/ ICAM-1/ NNP cord-015021-pol2qm74 1940 23 integrin integrin NN cord-015021-pol2qm74 1940 24 mediated mediate VBN cord-015021-pol2qm74 1940 25 . . . cord-015021-pol2qm74 1941 1 These these DT cord-015021-pol2qm74 1941 2 data datum NNS cord-015021-pol2qm74 1941 3 suggest suggest VBP cord-015021-pol2qm74 1941 4 , , , cord-015021-pol2qm74 1941 5 for for IN cord-015021-pol2qm74 1941 6 the the DT cord-015021-pol2qm74 1941 7 first first JJ cord-015021-pol2qm74 1941 8 time time NN cord-015021-pol2qm74 1941 9 , , , cord-015021-pol2qm74 1941 10 that that IN cord-015021-pol2qm74 1941 11 a a DT cord-015021-pol2qm74 1941 12 third third JJ cord-015021-pol2qm74 1941 13 endothelial endothelial JJ cord-015021-pol2qm74 1941 14 adhesion adhesion NN cord-015021-pol2qm74 1941 15 molecule molecule NN cord-015021-pol2qm74 1941 16 ( ( -LRB- cord-015021-pol2qm74 1941 17 PECAM PECAM NNP cord-015021-pol2qm74 1941 18 - - HYPH cord-015021-pol2qm74 1941 19 I I NNP cord-015021-pol2qm74 1941 20 ) ) -RRB- cord-015021-pol2qm74 1941 21 is be VBZ cord-015021-pol2qm74 1941 22 involved involve VBN cord-015021-pol2qm74 1941 23 in in IN cord-015021-pol2qm74 1941 24 the the DT cord-015021-pol2qm74 1941 25 coordinated coordinated JJ cord-015021-pol2qm74 1941 26 recruitment recruitment NN cord-015021-pol2qm74 1941 27 of of IN cord-015021-pol2qm74 1941 28 neutrophils neutrophil NNS cord-015021-pol2qm74 1941 29 in in IN cord-015021-pol2qm74 1941 30 vivo vivo NNP cord-015021-pol2qm74 1941 31 . . . cord-015021-pol2qm74 1942 1 To to TO cord-015021-pol2qm74 1942 2 test test VB cord-015021-pol2qm74 1942 3 whether whether IN cord-015021-pol2qm74 1942 4 trauma trauma NN cord-015021-pol2qm74 1942 5 causes cause NNS cord-015021-pol2qm74 1942 6 generalized generalized JJ cord-015021-pol2qm74 1942 7 activation activation NN cord-015021-pol2qm74 1942 8 or or CC cord-015021-pol2qm74 1942 9 priming priming NN cord-015021-pol2qm74 1942 10 of of IN cord-015021-pol2qm74 1942 11 PMNs pmn NNS cord-015021-pol2qm74 1942 12 , , , cord-015021-pol2qm74 1942 13 CDI8 CDI8 NNP cord-015021-pol2qm74 1942 14 adherence adherence NN cord-015021-pol2qm74 1942 15 receptors receptor NNS cord-015021-pol2qm74 1942 16 were be VBD cord-015021-pol2qm74 1942 17 measured measure VBN cord-015021-pol2qm74 1942 18 with with IN cord-015021-pol2qm74 1942 19 iinmunomonitoring iinmunomonitore VBG cord-015021-pol2qm74 1942 20 in in IN cord-015021-pol2qm74 1942 21 whole whole JJ cord-015021-pol2qm74 1942 22 blood blood NN cord-015021-pol2qm74 1942 23 after after IN cord-015021-pol2qm74 1942 24 LPS LPS NNP cord-015021-pol2qm74 1942 25 stimulation stimulation NN cord-015021-pol2qm74 1942 26 ex ex NN cord-015021-pol2qm74 1942 27 vivo vivo NN cord-015021-pol2qm74 1942 28 . . . cord-015021-pol2qm74 1943 1 Anesthetized anesthetized JJ cord-015021-pol2qm74 1943 2 ( ( -LRB- cord-015021-pol2qm74 1943 3 Fentanyl fentanyl NN cord-015021-pol2qm74 1943 4 ) ) -RRB- cord-015021-pol2qm74 1943 5 mongrel mongrel JJ cord-015021-pol2qm74 1943 6 pigs pig NNS cord-015021-pol2qm74 1943 7 ( ( -LRB- cord-015021-pol2qm74 1943 8 15 15 CD cord-015021-pol2qm74 1943 9 - - SYM cord-015021-pol2qm74 1943 10 25 25 CD cord-015021-pol2qm74 1943 11 kg kg NNS cord-015021-pol2qm74 1943 12 ) ) -RRB- cord-015021-pol2qm74 1943 13 were be VBD cord-015021-pol2qm74 1943 14 subjected subject VBN cord-015021-pol2qm74 1943 15 to to IN cord-015021-pol2qm74 1943 16 40 40 CD cord-015021-pol2qm74 1943 17 % % NN cord-015021-pol2qm74 1943 18 arterial arterial JJ cord-015021-pol2qm74 1943 19 hemorrhage hemorrhage NN cord-015021-pol2qm74 1943 20 + + CC cord-015021-pol2qm74 1943 21 soft soft JJ cord-015021-pol2qm74 1943 22 tissue tissue NN cord-015021-pol2qm74 1943 23 injury injury NN cord-015021-pol2qm74 1943 24 and and CC cord-015021-pol2qm74 1943 25 after after IN cord-015021-pol2qm74 1943 26 liar liar NN cord-015021-pol2qm74 1943 27 , , , cord-015021-pol2qm74 1943 28 resuscitated resuscitate VBD cord-015021-pol2qm74 1943 29 with with IN cord-015021-pol2qm74 1943 30 all all PDT cord-015021-pol2qm74 1943 31 the the DT cord-015021-pol2qm74 1943 32 shed shed JJ cord-015021-pol2qm74 1943 33 blood blood NN cord-015021-pol2qm74 1943 34 + + CC cord-015021-pol2qm74 1943 35 supplemental supplemental JJ cord-015021-pol2qm74 1943 36 fluid fluid NN cord-015021-pol2qm74 1943 37 . . . cord-015021-pol2qm74 1944 1 Blood blood NN cord-015021-pol2qm74 1944 2 was be VBD cord-015021-pol2qm74 1944 3 collected collect VBN cord-015021-pol2qm74 1944 4 at at IN cord-015021-pol2qm74 1944 5 24hr 24hr JJ cord-015021-pol2qm74 1944 6 intervals interval NNS cord-015021-pol2qm74 1944 7 from from IN cord-015021-pol2qm74 1944 8 unanesthetized unanesthetized JJ cord-015021-pol2qm74 1944 9 animals animal NNS cord-015021-pol2qm74 1944 10 with with IN cord-015021-pol2qm74 1944 11 indwelling indwell VBG cord-015021-pol2qm74 1944 12 catheters catheter NNS cord-015021-pol2qm74 1944 13 , , , cord-015021-pol2qm74 1944 14 PMNs pmn NNS cord-015021-pol2qm74 1944 15 were be VBD cord-015021-pol2qm74 1944 16 counted count VBN cord-015021-pol2qm74 1944 17 , , , cord-015021-pol2qm74 1944 18 and and CC cord-015021-pol2qm74 1944 19 LPS LPS NNP cord-015021-pol2qm74 1944 20 was be VBD cord-015021-pol2qm74 1944 21 added add VBN cord-015021-pol2qm74 1944 22 ( ( -LRB- cord-015021-pol2qm74 1944 23 0,1,5,10 0,1,5,10 JJ cord-015021-pol2qm74 1944 24 I.tg/ml i.tg/ml CD cord-015021-pol2qm74 1944 25 ) ) -RRB- cord-015021-pol2qm74 1944 26 ex ex NN cord-015021-pol2qm74 1944 27 vivo vivo NN cord-015021-pol2qm74 1944 28 . . . cord-015021-pol2qm74 1945 1 After after IN cord-015021-pol2qm74 1945 2 3hr 3hr JJ cord-015021-pol2qm74 1945 3 incubation incubation NN cord-015021-pol2qm74 1945 4 at at IN cord-015021-pol2qm74 1945 5 22 22 CD cord-015021-pol2qm74 1945 6 - - SYM cord-015021-pol2qm74 1945 7 24 24 CD cord-015021-pol2qm74 1945 8 ° ° NN cord-015021-pol2qm74 1945 9 C c NN cord-015021-pol2qm74 1945 10 , , , cord-015021-pol2qm74 1945 11 % % NN cord-015021-pol2qm74 1945 12 CD18 CD18 NNP cord-015021-pol2qm74 1945 13 ( ( -LRB- cord-015021-pol2qm74 1945 14 + + NNS cord-015021-pol2qm74 1945 15 ) ) -RRB- cord-015021-pol2qm74 1945 16 PMNs pmn NNS cord-015021-pol2qm74 1945 17 were be VBD cord-015021-pol2qm74 1945 18 determined determine VBN cord-015021-pol2qm74 1945 19 with with IN cord-015021-pol2qm74 1945 20 FITC FITC NNP cord-015021-pol2qm74 1945 21 - - HYPH cord-015021-pol2qm74 1945 22 IB4 ib4 NN cord-015021-pol2qm74 1945 23 and and CC cord-015021-pol2qm74 1945 24 flow flow VB cord-015021-pol2qm74 1945 25 cytometry cytometry NN cord-015021-pol2qm74 1945 26 from from IN cord-015021-pol2qm74 1945 27 mean mean JJ cord-015021-pol2qm74 1945 28 channel channel NN cord-015021-pol2qm74 1945 29 fluorescence fluorescence NN cord-015021-pol2qm74 1945 30 histograms histogram NNS cord-015021-pol2qm74 1945 31 . . . cord-015021-pol2qm74 1946 1 49±8 49±8 CD cord-015021-pol2qm74 1946 2 # # $ cord-015021-pol2qm74 1946 3 p<0.05 p<0.05 NN cord-015021-pol2qm74 1946 4 vs vs IN cord-015021-pol2qm74 1946 5 BASELINE BASELINE NNS cord-015021-pol2qm74 1947 1 * * NFP cord-015021-pol2qm74 1947 2 p<0.05 p<0.05 NNP cord-015021-pol2qm74 1947 3 vs vs IN cord-015021-pol2qm74 1947 4 sham sham JJ cord-015021-pol2qm74 1947 5 $ $ $ cord-015021-pol2qm74 1947 6 p<0.05 p<0.05 CD cord-015021-pol2qm74 1948 1 vs vs IN cord-015021-pol2qm74 1948 2 no no DT cord-015021-pol2qm74 1948 3 anesthesia anesthesia NN cord-015021-pol2qm74 1948 4 These these DT cord-015021-pol2qm74 1948 5 observations observation NNS cord-015021-pol2qm74 1948 6 provide provide VBP cord-015021-pol2qm74 1948 7 direct direct JJ cord-015021-pol2qm74 1948 8 evidence evidence NN cord-015021-pol2qm74 1948 9 for for IN cord-015021-pol2qm74 1948 10 time time NN cord-015021-pol2qm74 1948 11 - - HYPH cord-015021-pol2qm74 1948 12 dependent dependent JJ cord-015021-pol2qm74 1948 13 changes change NNS cord-015021-pol2qm74 1948 14 in in IN cord-015021-pol2qm74 1948 15 PMN pmn NN cord-015021-pol2qm74 1948 16 priming prime VBG cord-015021-pol2qm74 1948 17 following follow VBG cord-015021-pol2qm74 1948 18 major major JJ cord-015021-pol2qm74 1948 19 injury injury NN cord-015021-pol2qm74 1948 20 because because IN cord-015021-pol2qm74 1948 21 CD18 CD18 NNP cord-015021-pol2qm74 1948 22 expression expression NN cord-015021-pol2qm74 1948 23 was be VBD cord-015021-pol2qm74 1948 24 depressed depressed JJ cord-015021-pol2qm74 1948 25 for for IN cord-015021-pol2qm74 1948 26 at at IN cord-015021-pol2qm74 1948 27 ] ] -RRB- cord-015021-pol2qm74 1949 1 east east NNP cord-015021-pol2qm74 1949 2 24hr 24hr NNP cord-015021-pol2qm74 1949 3 after after IN cord-015021-pol2qm74 1949 4 trauma trauma NN cord-015021-pol2qm74 1950 1 relative relative JJ cord-015021-pol2qm74 1950 2 to to IN cord-015021-pol2qm74 1950 3 sham sham NN cord-015021-pol2qm74 1950 4 but but CC cord-015021-pol2qm74 1950 5 by by IN cord-015021-pol2qm74 1950 6 72hr 72hr NNP cord-015021-pol2qm74 1950 7 , , , cord-015021-pol2qm74 1950 8 was be VBD cord-015021-pol2qm74 1950 9 enhanced enhance VBN cord-015021-pol2qm74 1950 10 , , , cord-015021-pol2qm74 1950 11 relative relative JJ cord-015021-pol2qm74 1950 12 to to IN cord-015021-pol2qm74 1950 13 sham sham NN cord-015021-pol2qm74 1950 14 , , , cord-015021-pol2qm74 1950 15 and and CC cord-015021-pol2qm74 1950 16 because because IN cord-015021-pol2qm74 1950 17 fentanyl fentanyl NN cord-015021-pol2qm74 1950 18 anesthesia anesthesia NN cord-015021-pol2qm74 1950 19 at at IN cord-015021-pol2qm74 1950 20 72hr 72hr NNP cord-015021-pol2qm74 1950 21 had have VBD cord-015021-pol2qm74 1950 22 a a DT cord-015021-pol2qm74 1950 23 greater great JJR cord-015021-pol2qm74 1950 24 effect effect NN cord-015021-pol2qm74 1950 25 on on IN cord-015021-pol2qm74 1950 26 CD18 CD18 NNP cord-015021-pol2qm74 1950 27 expression expression NN cord-015021-pol2qm74 1950 28 in in IN cord-015021-pol2qm74 1950 29 trauma trauma NN cord-015021-pol2qm74 1950 30 vs vs IN cord-015021-pol2qm74 1950 31 sham sham NN cord-015021-pol2qm74 1950 32 . . . cord-015021-pol2qm74 1951 1 Neutrophil Neutrophil NNP cord-015021-pol2qm74 1951 2 ( ( -LRB- cord-015021-pol2qm74 1951 3 PMN pmn NN cord-015021-pol2qm74 1951 4 ) ) -RRB- cord-015021-pol2qm74 1951 5 adhesion adhesion NN cord-015021-pol2qm74 1951 6 to to IN cord-015021-pol2qm74 1951 7 vascular vascular JJ cord-015021-pol2qm74 1951 8 endothelial endothelial JJ cord-015021-pol2qm74 1951 9 cells cell NNS cord-015021-pol2qm74 1951 10 ( ( -LRB- cord-015021-pol2qm74 1951 11 •C •c NN cord-015021-pol2qm74 1951 12 ) ) -RRB- cord-015021-pol2qm74 1951 13 is be VBZ cord-015021-pol2qm74 1951 14 a a DT cord-015021-pol2qm74 1951 15 key key JJ cord-015021-pol2qm74 1951 16 element element NN cord-015021-pol2qm74 1951 17 in in IN cord-015021-pol2qm74 1951 18 the the DT cord-015021-pol2qm74 1951 19 inflammatory inflammatory JJ cord-015021-pol2qm74 1951 20 response response NN cord-015021-pol2qm74 1951 21 and and CC cord-015021-pol2qm74 1951 22 tissue tissue NN cord-015021-pol2qm74 1951 23 injury injury NN cord-015021-pol2qm74 1951 24 . . . cord-015021-pol2qm74 1952 1 Inflammatory inflammatory JJ cord-015021-pol2qm74 1952 2 mediators mediator NNS cord-015021-pol2qm74 1952 3 such such JJ cord-015021-pol2qm74 1952 4 as as IN cord-015021-pol2qm74 1952 5 LPS LPS NNP cord-015021-pol2qm74 1952 6 ( ( -LRB- cord-015021-pol2qm74 1952 7 exogenous exogenous JJ cord-015021-pol2qm74 1952 8 ) ) -RRB- cord-015021-pol2qm74 1952 9 and and CC cord-015021-pol2qm74 1952 10 TNF TNF NNP cord-015021-pol2qm74 1952 11 ( ( -LRB- cord-015021-pol2qm74 1952 12 endogenous endogenous JJ cord-015021-pol2qm74 1952 13 ) ) -RRB- cord-015021-pol2qm74 1952 14 can can MD cord-015021-pol2qm74 1952 15 promote promote VB cord-015021-pol2qm74 1952 16 PMN PMN NNP cord-015021-pol2qm74 1952 17 - - HYPH cord-015021-pol2qm74 1952 18 EC EC NNP cord-015021-pol2qm74 1952 19 interaction interaction NN cord-015021-pol2qm74 1952 20 which which WDT cord-015021-pol2qm74 1952 21 is be VBZ cord-015021-pol2qm74 1952 22 believed believe VBN cord-015021-pol2qm74 1952 23 to to TO cord-015021-pol2qm74 1952 24 be be VB cord-015021-pol2qm74 1952 25 responsible responsible JJ cord-015021-pol2qm74 1952 26 for for IN cord-015021-pol2qm74 1952 27 capillary capillary JJ cord-015021-pol2qm74 1952 28 leakage leakage NN cord-015021-pol2qm74 1952 29 and and CC cord-015021-pol2qm74 1952 30 subsequent subsequent JJ cord-015021-pol2qm74 1952 31 organ organ NN cord-015021-pol2qm74 1952 32 injury injury NN cord-015021-pol2qm74 1952 33 . . . cord-015021-pol2qm74 1953 1 However however RB cord-015021-pol2qm74 1953 2 , , , cord-015021-pol2qm74 1953 3 the the DT cord-015021-pol2qm74 1953 4 mechanism mechanism NN cord-015021-pol2qm74 1953 5 of of IN cord-015021-pol2qm74 1953 6 this this DT cord-015021-pol2qm74 1953 7 injury injury NN cord-015021-pol2qm74 1953 8 remains remain VBZ cord-015021-pol2qm74 1953 9 unclear unclear JJ cord-015021-pol2qm74 1953 10 . . . cord-015021-pol2qm74 1954 1 We -PRON- PRP cord-015021-pol2qm74 1954 2 hypothesised hypothesise VBD cord-015021-pol2qm74 1954 3 that that IN cord-015021-pol2qm74 1954 4 the the DT cord-015021-pol2qm74 1954 5 mechanism mechanism NN cord-015021-pol2qm74 1954 6 of of IN cord-015021-pol2qm74 1954 7 tissue tissue NN cord-015021-pol2qm74 1954 8 injury injury NN cord-015021-pol2qm74 1954 9 is be VBZ cord-015021-pol2qm74 1954 10 due due JJ cord-015021-pol2qm74 1954 11 to to IN cord-015021-pol2qm74 1954 12 EC EC NNP cord-015021-pol2qm74 1954 13 necrosis necrosis NN cord-015021-pol2qm74 1954 14 with with IN cord-015021-pol2qm74 1954 15 release release NN cord-015021-pol2qm74 1954 16 of of IN cord-015021-pol2qm74 1954 17 toxic toxic JJ cord-015021-pol2qm74 1954 18 products product NNS cord-015021-pol2qm74 1954 19 and and CC cord-015021-pol2qm74 1954 20 that that DT cord-015021-pol2qm74 1954 21 activated activate VBN cord-015021-pol2qm74 1954 22 PMN PMN NNP cord-015021-pol2qm74 1954 23 are be VBP cord-015021-pol2qm74 1954 24 responsible responsible JJ cord-015021-pol2qm74 1954 25 . . . cord-015021-pol2qm74 1955 1 Human Human NNP cord-015021-pol2qm74 1955 2 PMN PMN NNP cord-015021-pol2qm74 1955 3 were be VBD cord-015021-pol2qm74 1955 4 obtained obtain VBN cord-015021-pol2qm74 1955 5 from from IN cord-015021-pol2qm74 1955 6 healthy healthy JJ cord-015021-pol2qm74 1955 7 donors donor NNS cord-015021-pol2qm74 1955 8 , , , cord-015021-pol2qm74 1955 9 separated separate VBN cord-015021-pol2qm74 1955 10 by by IN cord-015021-pol2qm74 1955 11 density density NN cord-015021-pol2qm74 1955 12 gradient gradient NN cord-015021-pol2qm74 1955 13 , , , cord-015021-pol2qm74 1955 14 and and CC cord-015021-pol2qm74 1955 15 activated activate VBN cord-015021-pol2qm74 1955 16 with with IN cord-015021-pol2qm74 1955 17 LPS LPS NNP cord-015021-pol2qm74 1955 18 ( ( -LRB- cord-015021-pol2qm74 1955 19 50ng 50ng NNP cord-015021-pol2qm74 1955 20 / / SYM cord-015021-pol2qm74 1955 21 ml ml NN cord-015021-pol2qm74 1955 22 ) ) -RRB- cord-015021-pol2qm74 1955 23 , , , cord-015021-pol2qm74 1955 24 TNF(10ng TNF(10ng NNP cord-015021-pol2qm74 1955 25 / / SYM cord-015021-pol2qm74 1955 26 ml ml NNP cord-015021-pol2qm74 1955 27 ) ) -RRB- cord-015021-pol2qm74 1955 28 , , , cord-015021-pol2qm74 1955 29 and and CC cord-015021-pol2qm74 1955 30 LPS LPS NNP cord-015021-pol2qm74 1955 31 / / SYM cord-015021-pol2qm74 1955 32 TNF(25ng/10ng TNF(25ng/10ng NNP cord-015021-pol2qm74 1955 33 / / SYM cord-015021-pol2qm74 1955 34 ml ml NN cord-015021-pol2qm74 1955 35 ) ) -RRB- cord-015021-pol2qm74 1955 36 . . . cord-015021-pol2qm74 1956 1 Cultures culture NNS cord-015021-pol2qm74 1956 2 of of IN cord-015021-pol2qm74 1956 3 the the DT cord-015021-pol2qm74 1956 4 human human JJ cord-015021-pol2qm74 1956 5 EC EC NNP cord-015021-pol2qm74 1956 6 tine(ECV-304 tine(ECV-304 NNP cord-015021-pol2qm74 1956 7 ) ) -RRB- cord-015021-pol2qm74 1956 8 were be VBD cord-015021-pol2qm74 1956 9 used use VBN cord-015021-pol2qm74 1956 10 as as IN cord-015021-pol2qm74 1956 11 surrogates surrogate NNS cord-015021-pol2qm74 1956 12 of of IN cord-015021-pol2qm74 1956 13 the the DT cord-015021-pol2qm74 1956 14 microvasculature microvasculature NN cord-015021-pol2qm74 1956 15 , , , cord-015021-pol2qm74 1956 16 were be VBD cord-015021-pol2qm74 1956 17 exposed expose VBN cord-015021-pol2qm74 1956 18 to to IN cord-015021-pol2qm74 1956 19 either either CC cord-015021-pol2qm74 1956 20 LPS LPS NNP cord-015021-pol2qm74 1956 21 , , , cord-015021-pol2qm74 1956 22 TNF TNF NNP cord-015021-pol2qm74 1956 23 , , , cord-015021-pol2qm74 1956 24 LPS LPS NNP cord-015021-pol2qm74 1956 25 / / SYM cord-015021-pol2qm74 1956 26 TNF TNF NNP cord-015021-pol2qm74 1956 27 and and CC cord-015021-pol2qm74 1956 28 PMN PMN NNP cord-015021-pol2qm74 1956 29 activated activate VBD cord-015021-pol2qm74 1956 30 with with IN cord-015021-pol2qm74 1956 31 LPS LPS NNP cord-015021-pol2qm74 1956 32 , , , cord-015021-pol2qm74 1956 33 TNF TNF NNP cord-015021-pol2qm74 1956 34 , , , cord-015021-pol2qm74 1956 35 LPS LPS NNP cord-015021-pol2qm74 1956 36 / / SYM cord-015021-pol2qm74 1956 37 TNF TNF NNP cord-015021-pol2qm74 1956 38 and and CC cord-015021-pol2qm74 1956 39 incubated incubate VBN cord-015021-pol2qm74 1956 40 for for IN cord-015021-pol2qm74 1956 41 6 6 CD cord-015021-pol2qm74 1956 42 , , , cord-015021-pol2qm74 1956 43 12 12 CD cord-015021-pol2qm74 1956 44 , , , cord-015021-pol2qm74 1956 45 18 18 CD cord-015021-pol2qm74 1956 46 , , , cord-015021-pol2qm74 1956 47 and and CC cord-015021-pol2qm74 1956 48 24hrs 24hrs NN cord-015021-pol2qm74 1956 49 . . . cord-015021-pol2qm74 1957 1 EC EC NNP cord-015021-pol2qm74 1957 2 necrosis necrosis NN cord-015021-pol2qm74 1957 3 was be VBD cord-015021-pol2qm74 1957 4 assessed assess VBN cord-015021-pol2qm74 1957 5 by by IN cord-015021-pol2qm74 1957 6 a a DT cord-015021-pol2qm74 1957 7 51Cr 51cr CD cord-015021-pol2qm74 1957 8 release release NN cord-015021-pol2qm74 1957 9 cytotoxicity cytotoxicity NN cord-015021-pol2qm74 1957 10 assay assay NN cord-015021-pol2qm74 1957 11 . . . cord-015021-pol2qm74 1958 1 PMN pmn NN cord-015021-pol2qm74 1958 2 activation activation NN cord-015021-pol2qm74 1958 3 was be VBD cord-015021-pol2qm74 1958 4 assessed assess VBN cord-015021-pol2qm74 1958 5 by by IN cord-015021-pol2qm74 1958 6 CD1 CD1 NNP cord-015021-pol2qm74 1958 7 lb lb JJ cord-015021-pol2qm74 1958 8 receptor receptor NN cord-015021-pol2qm74 1958 9 expression expression NN cord-015021-pol2qm74 1958 10 and and CC cord-015021-pol2qm74 1958 11 respiratory respiratory JJ cord-015021-pol2qm74 1958 12 burst burst NN cord-015021-pol2qm74 1958 13 activity activity NN cord-015021-pol2qm74 1959 1 6hr 6hr NN cord-015021-pol2qm74 1959 2 0_+0 0_+0 CD cord-015021-pol2qm74 1960 1 1.7-+ 1.7-+ NNP cord-015021-pol2qm74 1960 2 1 1 CD cord-015021-pol2qm74 1961 1 0-+0 0-+0 CD cord-015021-pol2qm74 1961 2 3.2_+ 3.2_+ NN cord-015021-pol2qm74 1961 3 1 1 CD cord-015021-pol2qm74 1961 4 0_+0 0_+0 CD cord-015021-pol2qm74 1961 5 4.4_+ 4.4_+ CD cord-015021-pol2qm74 1961 6 1 1 CD cord-015021-pol2qm74 1961 7 0_+0 0_+0 CD cord-015021-pol2qm74 1962 1 2.3_+0.9 2.3_+0.9 CD cord-015021-pol2qm74 1962 2 12hr 12hr NN cord-015021-pol2qm74 1962 3 0 0 CD cord-015021-pol2qm74 1962 4 + + SYM cord-015021-pol2qm74 1962 5 0 0 CD cord-015021-pol2qm74 1963 1 3.24_3 3.24_3 LS cord-015021-pol2qm74 1963 2 0_+0 0_+0 CD cord-015021-pol2qm74 1964 1 9.3_+3 9.3_+3 CD cord-015021-pol2qm74 1964 2 0_+0 0_+0 CD cord-015021-pol2qm74 1964 3 11_+3 11_+3 CD cord-015021-pol2qm74 1965 1 " " `` cord-015021-pol2qm74 1965 2 0+_0 0+_0 CD cord-015021-pol2qm74 1965 3 12 12 CD cord-015021-pol2qm74 1966 1 + + LS cord-015021-pol2qm74 1966 2 --2.1 --2.1 : cord-015021-pol2qm74 1966 3 " " '' cord-015021-pol2qm74 1966 4 lghr lghr NNP cord-015021-pol2qm74 1966 5 04 04 CD cord-015021-pol2qm74 1966 6 - - SYM cord-015021-pol2qm74 1966 7 0 0 CD cord-015021-pol2qm74 1966 8 0.9_+2 0.9_+2 CD cord-015021-pol2qm74 1966 9 0+_0 0+_0 CD cord-015021-pol2qm74 1967 1 284 284 CD cord-015021-pol2qm74 1967 2 - - SYM cord-015021-pol2qm74 1967 3 12 12 CD cord-015021-pol2qm74 1968 1 " " `` cord-015021-pol2qm74 1968 2 O o UH cord-015021-pol2qm74 1968 3 : : : cord-015021-pol2qm74 1968 4 fO fO . cord-015021-pol2qm74 1969 1 25,12 25,12 CD cord-015021-pol2qm74 1969 2 " " `` cord-015021-pol2qm74 1969 3 0~0 0~0 CD cord-015021-pol2qm74 1969 4 30 30 CD cord-015021-pol2qm74 1970 1 + + CC cord-015021-pol2qm74 1970 2 -9.5 -9.5 NN cord-015021-pol2qm74 1971 1 * * NFP cord-015021-pol2qm74 1971 2 24hr 24hr NN cord-015021-pol2qm74 1971 3 0_+0 0_+0 CD cord-015021-pol2qm74 1972 1 4.14 4.14 CD cord-015021-pol2qm74 1972 2 - - SYM cord-015021-pol2qm74 1972 3 4 4 CD cord-015021-pol2qm74 1973 1 0-+0 0-+0 CD cord-015021-pol2qm74 1973 2 33+_3 33+_3 CD cord-015021-pol2qm74 1974 1 * * NFP cord-015021-pol2qm74 1974 2 0_+0 0_+0 CD cord-015021-pol2qm74 1974 3 30_+9 30_+9 CD cord-015021-pol2qm74 1975 1 * * NFP cord-015021-pol2qm74 1975 2 0_+0 0_+0 NFP cord-015021-pol2qm74 1975 3 32_+10 32_+10 CD cord-015021-pol2qm74 1975 4 " " `` cord-015021-pol2qm74 1975 5 Data data NN cord-015021-pol2qm74 1975 6 = = SYM cord-015021-pol2qm74 1975 7 EC EC NNP cord-015021-pol2qm74 1975 8 % % NN cord-015021-pol2qm74 1975 9 necrosis necrosis NN cord-015021-pol2qm74 1976 1 mean_+SD mean_+SD NNP cord-015021-pol2qm74 1976 2 Stats stat NNS cord-015021-pol2qm74 1976 3 : : : cord-015021-pol2qm74 1976 4 Student student NN cord-015021-pol2qm74 1976 5 's 's POS cord-015021-pol2qm74 1976 6 t t NN cord-015021-pol2qm74 1976 7 - - HYPH cord-015021-pol2qm74 1976 8 test test NN cord-015021-pol2qm74 1976 9 with with IN cord-015021-pol2qm74 1976 10 significance significance NN cord-015021-pol2qm74 1977 1 ( ( -LRB- cord-015021-pol2qm74 1977 2 * * NFP cord-015021-pol2qm74 1977 3 ) ) -RRB- cord-015021-pol2qm74 1977 4 set set VBN cord-015021-pol2qm74 1977 5 at at IN cord-015021-pol2qm74 1977 6 P<0.05 P<0.05 NNS cord-015021-pol2qm74 1977 7 vs vs IN cord-015021-pol2qm74 1977 8 control control NN cord-015021-pol2qm74 1977 9 . . . cord-015021-pol2qm74 1978 1 ( ( -LRB- cord-015021-pol2qm74 1978 2 Our -PRON- PRP$ cord-015021-pol2qm74 1978 3 previous previous JJ cord-015021-pol2qm74 1978 4 studies study NNS cord-015021-pol2qm74 1978 5 have have VBP cord-015021-pol2qm74 1978 6 indicated indicate VBN cord-015021-pol2qm74 1978 7 that that IN cord-015021-pol2qm74 1978 8 despite despite IN cord-015021-pol2qm74 1978 9 the the DT cord-015021-pol2qm74 1978 10 increased increase VBN cord-015021-pol2qm74 1978 11 cardiac cardiac JJ cord-015021-pol2qm74 1978 12 output output NN cord-015021-pol2qm74 1978 13 and and CC cord-015021-pol2qm74 1978 14 maintenance maintenance NN cord-015021-pol2qm74 1978 15 of of IN cord-015021-pol2qm74 1978 16 tissue tissue NN cord-015021-pol2qm74 1978 17 perfusion perfusion NN cord-015021-pol2qm74 1978 18 , , , cord-015021-pol2qm74 1978 19 hepatoceliular hepatoceliular JJ cord-015021-pol2qm74 1978 20 dysfunction dysfunction NN cord-015021-pol2qm74 1978 21 occurs occur VBZ cord-015021-pol2qm74 1978 22 during during IN cord-015021-pol2qm74 1978 23 early early JJ cord-015021-pol2qm74 1978 24 sepsis sepsis NN cord-015021-pol2qm74 1978 25 . . . cord-015021-pol2qm74 1979 1 Nonetheless nonetheless RB cord-015021-pol2qm74 1979 2 , , , cord-015021-pol2qm74 1979 3 it -PRON- PRP cord-015021-pol2qm74 1979 4 remains remain VBZ cord-015021-pol2qm74 1979 5 unknown unknown JJ cord-015021-pol2qm74 1979 6 whether whether IN cord-015021-pol2qm74 1979 7 vascular vascular JJ cord-015021-pol2qm74 1979 8 endothelial endothelial JJ cord-015021-pol2qm74 1979 9 cell cell NN cord-015021-pol2qm74 1979 10 function function NN cord-015021-pol2qm74 1979 11 ( ( -LRB- cord-015021-pol2qm74 1979 12 i.e. i.e. FW cord-015021-pol2qm74 1979 13 , , , cord-015021-pol2qm74 1979 14 the the DT cord-015021-pol2qm74 1979 15 release release NN cord-015021-pol2qm74 1979 16 of of IN cord-015021-pol2qm74 1979 17 endothelium endothelium NN cord-015021-pol2qm74 1979 18 - - HYPH cord-015021-pol2qm74 1979 19 derived derive VBN cord-015021-pol2qm74 1979 20 relaxing relax VBG cord-015021-pol2qm74 1979 21 factor factor NN cord-015021-pol2qm74 1979 22 / / SYM cord-015021-pol2qm74 1979 23 nitric nitric NN cord-015021-pol2qm74 1979 24 oxide oxide NN cord-015021-pol2qm74 1979 25 ) ) -RRB- cord-015021-pol2qm74 1979 26 is be VBZ cord-015021-pol2qm74 1979 27 depressed depress VBN cord-015021-pol2qm74 1979 28 under under IN cord-015021-pol2qm74 1979 29 such such JJ cord-015021-pol2qm74 1979 30 conditions condition NNS cord-015021-pol2qm74 1979 31 and and CC cord-015021-pol2qm74 1979 32 , , , cord-015021-pol2qm74 1979 33 if if IN cord-015021-pol2qm74 1979 34 so so RB cord-015021-pol2qm74 1979 35 , , , cord-015021-pol2qm74 1979 36 whether whether IN cord-015021-pol2qm74 1979 37 endothelial endothelial JJ cord-015021-pol2qm74 1979 38 cell cell NN cord-015021-pol2qm74 1979 39 dysfunction dysfunction NN cord-015021-pol2qm74 1979 40 also also RB cord-015021-pol2qm74 1979 41 occurs occur VBZ cord-015021-pol2qm74 1979 42 at at IN cord-015021-pol2qm74 1979 43 the the DT cord-015021-pol2qm74 1979 44 microcirculatory microcirculatory JJ cord-015021-pol2qm74 1979 45 level level NN cord-015021-pol2qm74 1979 46 . . . cord-015021-pol2qm74 1980 1 To to TO cord-015021-pol2qm74 1980 2 determine determine VB cord-015021-pol2qm74 1980 3 this this DT cord-015021-pol2qm74 1980 4 , , , cord-015021-pol2qm74 1980 5 rats rat NNS cord-015021-pol2qm74 1980 6 were be VBD cord-015021-pol2qm74 1980 7 subjected subject VBN cord-015021-pol2qm74 1980 8 to to IN cord-015021-pol2qm74 1980 9 sepsis sepsis NN cord-015021-pol2qm74 1980 10 by by IN cord-015021-pol2qm74 1980 11 cecal cecal JJ cord-015021-pol2qm74 1980 12 ligation ligation NN cord-015021-pol2qm74 1980 13 and and CC cord-015021-pol2qm74 1980 14 puncture puncture NN cord-015021-pol2qm74 1980 15 ( ( -LRB- cord-015021-pol2qm74 1980 16 CLP CLP NNP cord-015021-pol2qm74 1980 17 ) ) -RRB- cord-015021-pol2qm74 1980 18 , , , cord-015021-pol2qm74 1980 19 following follow VBG cord-015021-pol2qm74 1980 20 which which WDT cord-015021-pol2qm74 1980 21 these these DT cord-015021-pol2qm74 1980 22 and and CC cord-015021-pol2qm74 1980 23 corresponding corresponding JJ cord-015021-pol2qm74 1980 24 shams sham NNS cord-015021-pol2qm74 1980 25 received receive VBD cord-015021-pol2qm74 1980 26 3 3 CD cord-015021-pol2qm74 1980 27 ml/100 ml/100 NNS cord-015021-pol2qm74 1980 28 g g NNP cord-015021-pol2qm74 1980 29 BW BW NNP cord-015021-pol2qm74 1980 30 normal normal JJ cord-015021-pol2qm74 1980 31 saline saline NN cord-015021-pol2qm74 1980 32 . . . cord-015021-pol2qm74 1981 1 At at IN cord-015021-pol2qm74 1981 2 5 5 CD cord-015021-pol2qm74 1981 3 hr hr NN cord-015021-pol2qm74 1981 4 after after IN cord-015021-pol2qm74 1981 5 CLP CLP NNP cord-015021-pol2qm74 1981 6 ( ( -LRB- cord-015021-pol2qm74 1981 7 hyperdynamic hyperdynamic NNP cord-015021-pol2qm74 1981 8 sepsis sepsis NN cord-015021-pol2qm74 1981 9 ) ) -RRB- cord-015021-pol2qm74 1981 10 or or CC cord-015021-pol2qm74 1981 11 sham sham JJ cord-015021-pol2qm74 1981 12 operation operation NN cord-015021-pol2qm74 1981 13 , , , cord-015021-pol2qm74 1981 14 the the DT cord-015021-pol2qm74 1981 15 thoracic thoracic JJ cord-015021-pol2qm74 1981 16 aorta aorta NN cord-015021-pol2qm74 1981 17 was be VBD cord-015021-pol2qm74 1981 18 isolated isolate VBN cord-015021-pol2qm74 1981 19 , , , cord-015021-pol2qm74 1981 20 cut cut VBN cord-015021-pol2qm74 1981 21 into into IN cord-015021-pol2qm74 1981 22 rings ring NNS cord-015021-pol2qm74 1981 23 , , , cord-015021-pol2qm74 1981 24 and and CC cord-015021-pol2qm74 1981 25 placed place VBN cord-015021-pol2qm74 1981 26 in in IN cord-015021-pol2qm74 1981 27 organ organ NN cord-015021-pol2qm74 1981 28 chambers chamber NNS cord-015021-pol2qm74 1981 29 . . . cord-015021-pol2qm74 1982 1 Norepinephrine Norepinephrine NNP cord-015021-pol2qm74 1982 2 ( ( -LRB- cord-015021-pol2qm74 1982 3 NE NE NNP cord-015021-pol2qm74 1982 4 , , , cord-015021-pol2qm74 1982 5 2xI0 2xi0 CD cord-015021-pol2qm74 1982 6 -7 -7 NNP cord-015021-pol2qm74 1982 7 M M NNP cord-015021-pol2qm74 1982 8 ) ) -RRB- cord-015021-pol2qm74 1982 9 was be VBD cord-015021-pol2qm74 1982 10 used use VBN cord-015021-pol2qm74 1982 11 to to TO cord-015021-pol2qm74 1982 12 achieve achieve VB cord-015021-pol2qm74 1982 13 near near RB cord-015021-pol2qm74 1982 14 - - HYPH cord-015021-pol2qm74 1982 15 maximal maximal JJ cord-015021-pol2qm74 1982 16 contraction contraction NN cord-015021-pol2qm74 1982 17 . . . cord-015021-pol2qm74 1983 1 Responses response NNS cord-015021-pol2qm74 1983 2 for for IN cord-015021-pol2qm74 1983 3 an an DT cord-015021-pol2qm74 1983 4 endothelium endothelium NN cord-015021-pol2qm74 1983 5 - - HYPH cord-015021-pol2qm74 1983 6 dependeut dependeut VBN cord-015021-pol2qm74 1983 7 vasodilator vasodilator NN cord-015021-pol2qm74 1983 8 , , , cord-015021-pol2qm74 1983 9 acetylcholine acetylcholine NN cord-015021-pol2qm74 1983 10 ( ( -LRB- cord-015021-pol2qm74 1983 11 ACh ACh NNP cord-015021-pol2qm74 1983 12 , , , cord-015021-pol2qm74 1983 13 via via IN cord-015021-pol2qm74 1983 14 nitric nitric NN cord-015021-pol2qm74 1983 15 oxide oxide NN cord-015021-pol2qm74 1983 16 ) ) -RRB- cord-015021-pol2qm74 1983 17 , , , cord-015021-pol2qm74 1983 18 were be VBD cord-015021-pol2qm74 1983 19 determined determine VBN cord-015021-pol2qm74 1983 20 . . . cord-015021-pol2qm74 1984 1 In in IN cord-015021-pol2qm74 1984 2 additional additional JJ cord-015021-pol2qm74 1984 3 studies study NNS cord-015021-pol2qm74 1984 4 , , , cord-015021-pol2qm74 1984 5 the the DT cord-015021-pol2qm74 1984 6 small small JJ cord-015021-pol2qm74 1984 7 gut gut NN cord-015021-pol2qm74 1984 8 was be VBD cord-015021-pol2qm74 1984 9 isolated isolate VBN cord-015021-pol2qm74 1984 10 at at IN cord-015021-pol2qm74 1984 11 5 5 CD cord-015021-pol2qm74 1984 12 hr hr NN cord-015021-pol2qm74 1984 13 post post NN cord-015021-pol2qm74 1984 14 - - JJ cord-015021-pol2qm74 1984 15 CLP clp NN cord-015021-pol2qm74 1984 16 . . . cord-015021-pol2qm74 1985 1 After after IN cord-015021-pol2qm74 1985 2 pre pre JJ cord-015021-pol2qm74 1985 3 - - NN cord-015021-pol2qm74 1985 4 contraction contraction NN cord-015021-pol2qm74 1985 5 of of IN cord-015021-pol2qm74 1985 6 blood blood NN cord-015021-pol2qm74 1985 7 vessels vessel NNS cord-015021-pol2qm74 1985 8 in in IN cord-015021-pol2qm74 1985 9 the the DT cord-015021-pol2qm74 1985 10 isolated isolate VBN cord-015021-pol2qm74 1985 11 gut gut NN cord-015021-pol2qm74 1985 12 with with IN cord-015021-pol2qm74 1985 13 5xl04 5xl04 CD cord-015021-pol2qm74 1985 14 M M NNP cord-015021-pol2qm74 1985 15 NE NE NNP cord-015021-pol2qm74 1985 16 , , , cord-015021-pol2qm74 1985 17 vascular vascular JJ cord-015021-pol2qm74 1985 18 responses response NNS cord-015021-pol2qm74 1985 19 to to IN cord-015021-pol2qm74 1985 20 ACh ACh NNP cord-015021-pol2qm74 1985 21 ( ( -LRB- cord-015021-pol2qm74 1985 22 5x10 5x10 CD cord-015021-pol2qm74 1985 23 6 6 CD cord-015021-pol2qm74 1985 24 M M NNP cord-015021-pol2qm74 1985 25 ) ) -RRB- cord-015021-pol2qm74 1985 26 and and CC cord-015021-pol2qm74 1985 27 an an DT cord-015021-pol2qm74 1985 28 endotheliumindependent endotheliumindependent NN cord-015021-pol2qm74 1985 29 vasodiiator vasodiiator NN cord-015021-pol2qm74 1985 30 , , , cord-015021-pol2qm74 1985 31 nitroglycerine nitroglycerine NN cord-015021-pol2qm74 1985 32 ( ( -LRB- cord-015021-pol2qm74 1985 33 NTG NTG NNP cord-015021-pol2qm74 1985 34 , , , cord-015021-pol2qm74 1985 35 5xl0 5xl0 CD cord-015021-pol2qm74 1985 36 -7 -7 IN cord-015021-pol2qm74 1985 37 M M NNP cord-015021-pol2qm74 1985 38 ) ) -RRB- cord-015021-pol2qm74 1985 39 , , , cord-015021-pol2qm74 1985 40 were be VBD cord-015021-pol2qm74 1985 41 determined determine VBN cord-015021-pol2qm74 1985 42 . . . cord-015021-pol2qm74 1986 1 Total total JJ cord-015021-pol2qm74 1986 2 vascular vascular JJ cord-015021-pol2qm74 1986 3 resistance resistance NN cord-015021-pol2qm74 1986 4 ( ( -LRB- cord-015021-pol2qm74 1986 5 TVR TVR NNP cord-015021-pol2qm74 1986 6 , , , cord-015021-pol2qm74 1986 7 mmHg mmHg NNP cord-015021-pol2qm74 1986 8 / / SYM cord-015021-pol2qm74 1986 9 mi mi NNP cord-015021-pol2qm74 1986 10 / / SYM cord-015021-pol2qm74 1986 11 min/100 min/100 NNS cord-015021-pol2qm74 1986 12 g g NNP cord-015021-pol2qm74 1986 13 ) ) -RRB- cord-015021-pol2qm74 1986 14 was be VBD cord-015021-pol2qm74 1986 15 then then RB cord-015021-pol2qm74 1986 16 calculated calculate VBN cord-015021-pol2qm74 1986 17 as as IN cord-015021-pol2qm74 1986 18 pressure/ pressure/ CD cord-015021-pol2qm74 1986 19 perfusinn perfusinn NN cord-015021-pol2qm74 1986 20 rate rate NN cord-015021-pol2qm74 1986 21 . . . cord-015021-pol2qm74 1987 1 ACh ACh NNP cord-015021-pol2qm74 1987 2 - - HYPH cord-015021-pol2qm74 1987 3 induced induce VBN cord-015021-pol2qm74 1987 4 relaxation relaxation NN cord-015021-pol2qm74 1987 5 ( ( -LRB- cord-015021-pol2qm74 1987 6 % % NN cord-015021-pol2qm74 1987 7 , , , cord-015021-pol2qm74 1987 8 n=6 n=6 JJ cord-015021-pol2qm74 1987 9 / / SYM cord-015021-pol2qm74 1987 10 group group NN cord-015021-pol2qm74 1987 11 ) ) -RRB- cord-015021-pol2qm74 1987 12 in in IN cord-015021-pol2qm74 1987 13 the the DT cord-015021-pol2qm74 1987 14 aortic aortic JJ cord-015021-pol2qm74 1987 15 rings ring NNS cord-015021-pol2qm74 1987 16 were be VBD cord-015021-pol2qm74 1987 17 : : : cord-015021-pol2qm74 1988 1 ACh ACh NNP cord-015021-pol2qm74 1988 2 lxl0 lxl0 NNP cord-015021-pol2qm74 1988 3 i i NNP cord-015021-pol2qm74 1988 4 ~ ~ NFP cord-015021-pol2qm74 1988 5 s s NNP cord-015021-pol2qm74 1988 6 , , , cord-015021-pol2qm74 1989 1 sT sT NNP cord-015021-pol2qm74 1989 2 - - HYPH cord-015021-pol2qm74 1989 3 in in IN cord-015021-pol2qm74 1989 4 ~ ~ NFP cord-015021-pol2qm74 1989 5 ~ ~ NFP cord-015021-pol2qm74 1989 6 significantly significantly RB cord-015021-pol2qm74 1989 7 at at IN cord-015021-pol2qm74 1989 8 5 5 CD cord-015021-pol2qm74 1989 9 hr hr NN cord-015021-pol2qm74 1989 10 post post NN cord-015021-pol2qm74 1989 11 - - JJ cord-015021-pol2qm74 1989 12 CLP clp NN cord-015021-pol2qm74 1989 13 ( ( -LRB- cord-015021-pol2qm74 1989 14 i.e. i.e. FW cord-015021-pol2qm74 1989 15 , , , cord-015021-pol2qm74 1989 16 increased increase VBN cord-015021-pol2qm74 1989 17 * * NFP cord-015021-pol2qm74 1989 18 P(O p(o NN cord-015021-pol2qm74 1989 19 05 05 CD cord-015021-pol2qm74 1989 20 vs. vs. IN cord-015021-pol2qm74 1989 21 Sham Sham NNP cord-015021-pol2qm74 1989 22 ; ; : cord-015021-pol2qm74 1989 23 N-4 N-4 NNP cord-015021-pol2qm74 1989 24 per per IN cord-015021-pol2qm74 1989 25 group group NN cord-015021-pol2qm74 1989 26 . . . cord-015021-pol2qm74 1990 1 TVR TVR NNP cord-015021-pol2qm74 1990 2 ) ) -RRB- cord-015021-pol2qm74 1991 1 in in IN cord-015021-pol2qm74 1991 2 the the DT cord-015021-pol2qm74 1991 3 absence absence NN cord-015021-pol2qm74 1991 4 of of IN cord-015021-pol2qm74 1991 5 any any DT cord-015021-pol2qm74 1991 6 changes change NNS cord-015021-pol2qm74 1991 7 in in IN cord-015021-pol2qm74 1991 8 NTGinduced ntginduced JJ cord-015021-pol2qm74 1991 9 relaxation relaxation NN cord-015021-pol2qm74 1991 10 ( ( -LRB- cord-015021-pol2qm74 1991 11 Fig fig NN cord-015021-pol2qm74 1991 12 . . . cord-015021-pol2qm74 1992 1 A a LS cord-015021-pol2qm74 1992 2 ) ) -RRB- cord-015021-pol2qm74 1992 3 . . . cord-015021-pol2qm74 1993 1 Thus thus RB cord-015021-pol2qm74 1993 2 , , , cord-015021-pol2qm74 1993 3 the the DT cord-015021-pol2qm74 1993 4 vascular vascular JJ cord-015021-pol2qm74 1993 5 endothelial endothelial JJ cord-015021-pol2qm74 1993 6 cell cell NN cord-015021-pol2qm74 1993 7 dysfunction dysfunction NN cord-015021-pol2qm74 1993 8 observed observe VBN cord-015021-pol2qm74 1993 9 in in IN cord-015021-pol2qm74 1993 10 the the DT cord-015021-pol2qm74 1993 11 aorta aorta NN cord-015021-pol2qm74 1993 12 in in IN cord-015021-pol2qm74 1993 13 early early JJ cord-015021-pol2qm74 1993 14 sepsis sepsis NN cord-015021-pol2qm74 1993 15 also also RB cord-015021-pol2qm74 1993 16 occurs occur VBZ cord-015021-pol2qm74 1993 17 at at IN cord-015021-pol2qm74 1993 18 the the DT cord-015021-pol2qm74 1993 19 microcirculatory microcirculatory JJ cord-015021-pol2qm74 1993 20 level level NN cord-015021-pol2qm74 1993 21 . . . cord-015021-pol2qm74 1993 22 _SP cord-015021-pol2qm74 1994 1 Introduction introduction NN cord-015021-pol2qm74 1994 2 : : : cord-015021-pol2qm74 1995 1 The the DT cord-015021-pol2qm74 1995 2 cytokine cytokine NN cord-015021-pol2qm74 1995 3 - - HYPH cord-015021-pol2qm74 1995 4 mediated mediate VBN cord-015021-pol2qm74 1995 5 adherence adherence NN cord-015021-pol2qm74 1995 6 of of IN cord-015021-pol2qm74 1995 7 leulcooytes leulcooyte NNS cord-015021-pol2qm74 1995 8 to to IN cord-015021-pol2qm74 1995 9 vascular vascular JJ cord-015021-pol2qm74 1995 10 endothelium endothelium NN cord-015021-pol2qm74 1995 11 is be VBZ cord-015021-pol2qm74 1995 12 considered consider VBN cord-015021-pol2qm74 1995 13 as as IN cord-015021-pol2qm74 1995 14 an an DT cord-015021-pol2qm74 1995 15 early early JJ cord-015021-pol2qm74 1995 16 step step NN cord-015021-pol2qm74 1995 17 in in IN cord-015021-pol2qm74 1995 18 the the DT cord-015021-pol2qm74 1995 19 cascade cascade NN cord-015021-pol2qm74 1995 20 of of IN cord-015021-pol2qm74 1995 21 pathologic pathologic JJ cord-015021-pol2qm74 1995 22 reactions reaction NNS cord-015021-pol2qm74 1995 23 culminating culminate VBG cord-015021-pol2qm74 1995 24 in in IN cord-015021-pol2qm74 1995 25 the the DT cord-015021-pol2qm74 1995 26 " " `` cord-015021-pol2qm74 1995 27 systemic systemic JJ cord-015021-pol2qm74 1995 28 inflammatory inflammatory JJ cord-015021-pol2qm74 1995 29 response response NN cord-015021-pol2qm74 1995 30 syndrome syndrome NN cord-015021-pol2qm74 1995 31 " " '' cord-015021-pol2qm74 1995 32 ( ( -LRB- cord-015021-pol2qm74 1995 33 SIRS sirs UH cord-015021-pol2qm74 1995 34 ) ) -RRB- cord-015021-pol2qm74 1995 35 ; ; : cord-015021-pol2qm74 1995 36 The the DT cord-015021-pol2qm74 1995 37 purpose purpose NN cord-015021-pol2qm74 1995 38 of of IN cord-015021-pol2qm74 1995 39 this this DT cord-015021-pol2qm74 1995 40 study study NN cord-015021-pol2qm74 1995 41 was be VBD cord-015021-pol2qm74 1995 42 to to TO cord-015021-pol2qm74 1995 43 evaluate evaluate VB cord-015021-pol2qm74 1995 44 the the DT cord-015021-pol2qm74 1995 45 influence influence NN cord-015021-pol2qm74 1995 46 of of IN cord-015021-pol2qm74 1995 47 interleakin-1 interleakin-1 NNP cord-015021-pol2qm74 1995 48 on on IN cord-015021-pol2qm74 1995 49 leukooyteendothelial leukooyteendothelial JJ cord-015021-pol2qm74 1995 50 cell cell NN cord-015021-pol2qm74 1995 51 - - HYPH cord-015021-pol2qm74 1995 52 interactions interaction NNS cord-015021-pol2qm74 1995 53 and and CC cord-015021-pol2qm74 1995 54 microoirculation microoirculation NN cord-015021-pol2qm74 1995 55 in in IN cord-015021-pol2qm74 1995 56 the the DT cord-015021-pol2qm74 1995 57 liver liver NN cord-015021-pol2qm74 1995 58 after after IN cord-015021-pol2qm74 1995 59 hemorrhagic hemorrhagic JJ cord-015021-pol2qm74 1995 60 shock shock NN cord-015021-pol2qm74 1995 61 by by IN cord-015021-pol2qm74 1995 62 means mean NNS cord-015021-pol2qm74 1995 63 of of IN cord-015021-pol2qm74 1995 64 intravital intravital JJ cord-015021-pol2qm74 1995 65 microscopy microscopy NNS cord-015021-pol2qm74 1995 66 . . . cord-015021-pol2qm74 1996 1 Methods method NNS cord-015021-pol2qm74 1996 2 : : : cord-015021-pol2qm74 1996 3 In in IN cord-015021-pol2qm74 1996 4 anesthetized anesthetized JJ cord-015021-pol2qm74 1996 5 female female JJ cord-015021-pol2qm74 1996 6 SPRDrats sprdrat NNS cord-015021-pol2qm74 1996 7 Co.w Co.w NNP cord-015021-pol2qm74 1996 8 . . . cord-015021-pol2qm74 1997 1 200 200 CD cord-015021-pol2qm74 1997 2 - - SYM cord-015021-pol2qm74 1997 3 230 230 CD cord-015021-pol2qm74 1997 4 g g NN cord-015021-pol2qm74 1997 5 ) ) -RRB- cord-015021-pol2qm74 1997 6 shook shake VBD cord-015021-pol2qm74 1997 7 was be VBD cord-015021-pol2qm74 1997 8 induced induce VBN cord-015021-pol2qm74 1997 9 by by IN cord-015021-pol2qm74 1997 10 fractionated fractionate VBN cord-015021-pol2qm74 1997 11 withdrawl withdrawl NN cord-015021-pol2qm74 1997 12 of of IN cord-015021-pol2qm74 1997 13 arterial arterial JJ cord-015021-pol2qm74 1997 14 blood blood NN cord-015021-pol2qm74 1997 15 within within IN cord-015021-pol2qm74 1997 16 5 5 CD cord-015021-pol2qm74 1997 17 rain rain NN cord-015021-pol2qm74 1997 18 and and CC cord-015021-pol2qm74 1997 19 maintained maintain VBD cord-015021-pol2qm74 1997 20 for for IN cord-015021-pol2qm74 1997 21 1 1 CD cord-015021-pol2qm74 1997 22 h h NN cord-015021-pol2qm74 1997 23 ( ( -LRB- cord-015021-pol2qm74 1997 24 MAP MAP NNP cord-015021-pol2qm74 1997 25 at at IN cord-015021-pol2qm74 1997 26 40 40 CD cord-015021-pol2qm74 1997 27 mm mm CD cord-015021-pol2qm74 1997 28 Hg Hg NNP cord-015021-pol2qm74 1997 29 , , , cord-015021-pol2qm74 1997 30 Cardiac cardiac JJ cord-015021-pol2qm74 1997 31 output output NN cord-015021-pol2qm74 1997 32 50 50 CD cord-015021-pol2qm74 1997 33 % % NN cord-015021-pol2qm74 1997 34 of of IN cord-015021-pol2qm74 1997 35 baseline baseline NN cord-015021-pol2qm74 1997 36 ) ) -RRB- cord-015021-pol2qm74 1997 37 . . . cord-015021-pol2qm74 1998 1 Rats rat NNS cord-015021-pol2qm74 1998 2 were be VBD cord-015021-pol2qm74 1998 3 adequately adequately RB cord-015021-pol2qm74 1998 4 resuscitated resuscitate VBN cord-015021-pol2qm74 1998 5 with with IN cord-015021-pol2qm74 1998 6 60 60 CD cord-015021-pol2qm74 1998 7 % % NN cord-015021-pol2qm74 1998 8 of of IN cord-015021-pol2qm74 1998 9 shed shed JJ cord-015021-pol2qm74 1998 10 blood blood NN cord-015021-pol2qm74 1998 11 and and CC cord-015021-pol2qm74 1998 12 twice twice PDT cord-015021-pol2qm74 1998 13 the the DT cord-015021-pol2qm74 1998 14 volume volume NN cord-015021-pol2qm74 1998 15 in in IN cord-015021-pol2qm74 1998 16 Ringer Ringer NNP cord-015021-pol2qm74 1998 17 's 's POS cord-015021-pol2qm74 1998 18 solution solution NN cord-015021-pol2qm74 1998 19 additionally additionally RB cord-015021-pol2qm74 1998 20 . . . cord-015021-pol2qm74 1999 1 Following follow VBG cord-015021-pol2qm74 1999 2 5 5 CD cord-015021-pol2qm74 1999 3 h h NN cord-015021-pol2qm74 1999 4 of of IN cord-015021-pol2qm74 1999 5 reperfusinn reperfusinn NNP cord-015021-pol2qm74 1999 6 ( ( -LRB- cord-015021-pol2qm74 1999 7 MAP MAP NNP cord-015021-pol2qm74 1999 8 > > XX cord-015021-pol2qm74 2000 1 100 100 CD cord-015021-pol2qm74 2000 2 mm mm CD cord-015021-pol2qm74 2000 3 Hg Hg NNP cord-015021-pol2qm74 2000 4 , , , cord-015021-pol2qm74 2000 5 CO co NN cord-015021-pol2qm74 2000 6 > > XX cord-015021-pol2qm74 2000 7 120 120 CD cord-015021-pol2qm74 2000 8 % % NN cord-015021-pol2qm74 2000 9 of of IN cord-015021-pol2qm74 2000 10 baseline baseline NN cord-015021-pol2qm74 2000 11 ) ) -RRB- cord-015021-pol2qm74 2001 1 the the DT cord-015021-pol2qm74 2001 2 microcirculation microcirculation NN cord-015021-pol2qm74 2001 3 in in IN cord-015021-pol2qm74 2001 4 liver liver NN cord-015021-pol2qm74 2001 5 lobules lobule NNS cord-015021-pol2qm74 2001 6 was be VBD cord-015021-pol2qm74 2001 7 examined examine VBN cord-015021-pol2qm74 2001 8 by by IN cord-015021-pol2qm74 2001 9 intravital intravital JJ cord-015021-pol2qm74 2001 10 fluorescence fluorescence NN cord-015021-pol2qm74 2001 11 microscopy microscopy NNS cord-015021-pol2qm74 2001 12 after after IN cord-015021-pol2qm74 2001 13 labelling labelling NN cord-015021-pol2qm74 2001 14 of of IN cord-015021-pol2qm74 2001 15 leukocytes leukocyte NNS cord-015021-pol2qm74 2001 16 . . . cord-015021-pol2qm74 2002 1 Continuous continuous JJ cord-015021-pol2qm74 2002 2 administration administration NN cord-015021-pol2qm74 2002 3 of of IN cord-015021-pol2qm74 2002 4 IL IL NNP cord-015021-pol2qm74 2002 5 - - HYPH cord-015021-pol2qm74 2002 6 lra lra NNP cord-015021-pol2qm74 2002 7 ( ( -LRB- cord-015021-pol2qm74 2002 8 Synergen Synergen NNP cord-015021-pol2qm74 2002 9 , , , cord-015021-pol2qm74 2002 10 Boulder Boulder NNP cord-015021-pol2qm74 2002 11 , , , cord-015021-pol2qm74 2002 12 Colorado Colorado NNP cord-015021-pol2qm74 2002 13 , , , cord-015021-pol2qm74 2002 14 5mg 5mg NN cord-015021-pol2qm74 2002 15 / / SYM cord-015021-pol2qm74 2002 16 kg kg NNP cord-015021-pol2qm74 2002 17 / / SYM cord-015021-pol2qm74 2002 18 h h NN cord-015021-pol2qm74 2002 19 ) ) -RRB- cord-015021-pol2qm74 2002 20 was be VBD cord-015021-pol2qm74 2002 21 started start VBN cord-015021-pol2qm74 2002 22 at at IN cord-015021-pol2qm74 2002 23 different different JJ cord-015021-pol2qm74 2002 24 time time NN cord-015021-pol2qm74 2002 25 points point NNS cord-015021-pol2qm74 2002 26 in in IN cord-015021-pol2qm74 2002 27 a a DT cord-015021-pol2qm74 2002 28 randomized randomized JJ cord-015021-pol2qm74 2002 29 and and CC cord-015021-pol2qm74 2002 30 blinded blinded JJ cord-015021-pol2qm74 2002 31 manner manner NN cord-015021-pol2qm74 2002 32 . . . cord-015021-pol2qm74 2003 1 The the DT cord-015021-pol2qm74 2003 2 animals animal NNS cord-015021-pol2qm74 2003 3 in in IN cord-015021-pol2qm74 2003 4 group group NN cord-015021-pol2qm74 2003 5 P p NN cord-015021-pol2qm74 2003 6 ( ( -LRB- cord-015021-pol2qm74 2003 7 n=6 n=6 NNP cord-015021-pol2qm74 2003 8 ) ) -RRB- cord-015021-pol2qm74 2003 9 received receive VBD cord-015021-pol2qm74 2003 10 the the DT cord-015021-pol2qm74 2003 11 IL IL NNP cord-015021-pol2qm74 2003 12 - - HYPH cord-015021-pol2qm74 2003 13 lra lra NNP cord-015021-pol2qm74 2003 14 as as IN cord-015021-pol2qm74 2003 15 pretreatment pretreatment NN cord-015021-pol2qm74 2003 16 beginning begin VBG cord-015021-pol2qm74 2003 17 5 5 CD cord-015021-pol2qm74 2003 18 min min NN cord-015021-pol2qm74 2003 19 prior prior RB cord-015021-pol2qm74 2003 20 to to IN cord-015021-pol2qm74 2003 21 shock shock NN cord-015021-pol2qm74 2003 22 induction induction NN cord-015021-pol2qm74 2003 23 . . . cord-015021-pol2qm74 2004 1 In in IN cord-015021-pol2qm74 2004 2 the the DT cord-015021-pol2qm74 2004 3 group group NN cord-015021-pol2qm74 2004 4 T T NNP cord-015021-pol2qm74 2004 5 ( ( -LRB- cord-015021-pol2qm74 2004 6 n=6 n=6 NNP cord-015021-pol2qm74 2004 7 ) ) -RRB- cord-015021-pol2qm74 2004 8 the the DT cord-015021-pol2qm74 2004 9 application application NN cord-015021-pol2qm74 2004 10 of of IN cord-015021-pol2qm74 2004 11 IL IL NNP cord-015021-pol2qm74 2004 12 - - HYPH cord-015021-pol2qm74 2004 13 lm lm NNP cord-015021-pol2qm74 2004 14 started start VBD cord-015021-pol2qm74 2004 15 at at IN cord-015021-pol2qm74 2004 16 the the DT cord-015021-pol2qm74 2004 17 beginning beginning NN cord-015021-pol2qm74 2004 18 of of IN cord-015021-pol2qm74 2004 19 the the DT cord-015021-pol2qm74 2004 20 reperfusion reperfusion NN cord-015021-pol2qm74 2004 21 period period NN cord-015021-pol2qm74 2004 22 with with IN cord-015021-pol2qm74 2004 23 a a DT cord-015021-pol2qm74 2004 24 bolus bolus NN cord-015021-pol2qm74 2004 25 injection injection NN cord-015021-pol2qm74 2004 26 of of IN cord-015021-pol2qm74 2004 27 5 5 CD cord-015021-pol2qm74 2004 28 mg mg NNP cord-015021-pol2qm74 2004 29 / / SYM cord-015021-pol2qm74 2004 30 kg kg NNP cord-015021-pol2qm74 2004 31 and and CC cord-015021-pol2qm74 2004 32 was be VBD cord-015021-pol2qm74 2004 33 followed follow VBN cord-015021-pol2qm74 2004 34 by by IN cord-015021-pol2qm74 2004 35 continuons continuon NNS cord-015021-pol2qm74 2004 36 administration administration NN cord-015021-pol2qm74 2004 37 of of IN cord-015021-pol2qm74 2004 38 5 5 CD cord-015021-pol2qm74 2004 39 mg mg NNP cord-015021-pol2qm74 2004 40 / / SYM cord-015021-pol2qm74 2004 41 kg kg NNP cord-015021-pol2qm74 2004 42 / / SYM cord-015021-pol2qm74 2004 43 h h NN cord-015021-pol2qm74 2004 44 . . . cord-015021-pol2qm74 2005 1 The the DT cord-015021-pol2qm74 2005 2 control control NN cord-015021-pol2qm74 2005 3 group group NN cord-015021-pol2qm74 2005 4 C C NNP cord-015021-pol2qm74 2005 5 ( ( -LRB- cord-015021-pol2qm74 2005 6 n=4 n=4 NNP cord-015021-pol2qm74 2005 7 ) ) -RRB- cord-015021-pol2qm74 2005 8 received receive VBD cord-015021-pol2qm74 2005 9 equal equal JJ cord-015021-pol2qm74 2005 10 volumes volume NNS cord-015021-pol2qm74 2005 11 in in IN cord-015021-pol2qm74 2005 12 NaC10,9 nac10,9 CD cord-015021-pol2qm74 2005 13 % % NN cord-015021-pol2qm74 2005 14 , , , cord-015021-pol2qm74 2005 15 the the DT cord-015021-pol2qm74 2005 16 sham sham NN cord-015021-pol2qm74 2005 17 - - HYPH cord-015021-pol2qm74 2005 18 operated operate VBN cord-015021-pol2qm74 2005 19 group group NN cord-015021-pol2qm74 2005 20 S S NNP cord-015021-pol2qm74 2005 21 ( ( -LRB- cord-015021-pol2qm74 2005 22 n=4 n=4 NNP cord-015021-pol2qm74 2005 23 ) ) -RRB- cord-015021-pol2qm74 2005 24 was be VBD cord-015021-pol2qm74 2005 25 not not RB cord-015021-pol2qm74 2005 26 exposed expose VBN cord-015021-pol2qm74 2005 27 to to IN cord-015021-pol2qm74 2005 28 shock shock NN cord-015021-pol2qm74 2005 29 . . . cord-015021-pol2qm74 2006 1 Results result NNS cord-015021-pol2qm74 2006 2 : : : cord-015021-pol2qm74 2007 1 Macrohemodynamics macrohemodynamic NNS cord-015021-pol2qm74 2007 2 were be VBD cord-015021-pol2qm74 2007 3 comparable comparable JJ cord-015021-pol2qm74 2007 4 in in IN cord-015021-pol2qm74 2007 5 all all DT cord-015021-pol2qm74 2007 6 shook shake VBD cord-015021-pol2qm74 2007 7 groups group NNS cord-015021-pol2qm74 2007 8 . . . cord-015021-pol2qm74 2008 1 The the DT cord-015021-pol2qm74 2008 2 increased increase VBN cord-015021-pol2qm74 2008 3 percentage percentage NN cord-015021-pol2qm74 2008 4 of of IN cord-015021-pol2qm74 2008 5 permanendy permanendy NNP cord-015021-pol2qm74 2008 6 adherent adherent JJ cord-015021-pol2qm74 2008 7 leukocytes leukocyte NNS cord-015021-pol2qm74 2008 8 after after IN cord-015021-pol2qm74 2008 9 hemorrhagic hemorrhagic JJ cord-015021-pol2qm74 2008 10 shook shake VBD cord-015021-pol2qm74 2008 11 ( ( -LRB- cord-015021-pol2qm74 2008 12 S s NN cord-015021-pol2qm74 2008 13 : : : cord-015021-pol2qm74 2008 14 9,1 9,1 CD cord-015021-pol2qm74 2008 15 % % NN cord-015021-pol2qm74 2008 16 +1,1 +1,1 CD cord-015021-pol2qm74 2008 17 % % NN cord-015021-pol2qm74 2008 18 ; ; : cord-015021-pol2qm74 2008 19 C c NN cord-015021-pol2qm74 2008 20 : : : cord-015021-pol2qm74 2008 21 42,1 42,1 CD cord-015021-pol2qm74 2008 22 % % NN cord-015021-pol2qm74 2008 23 _ _ NN cord-015021-pol2qm74 2008 24 +5,4 +5,4 CD cord-015021-pol2qm74 2008 25 % % NN cord-015021-pol2qm74 2008 26 ) ) -RRB- cord-015021-pol2qm74 2008 27 was be VBD cord-015021-pol2qm74 2008 28 significantly significantly RB cord-015021-pol2qm74 2008 29 reduced reduce VBN cord-015021-pol2qm74 2008 30 by by IN cord-015021-pol2qm74 2008 31 pretreatment pretreatment NN cord-015021-pol2qm74 2008 32 or or CC cord-015021-pol2qm74 2008 33 treatment treatment NN cord-015021-pol2qm74 2008 34 with with IN cord-015021-pol2qm74 2008 35 IL IL NNP cord-015021-pol2qm74 2008 36 - - HYPH cord-015021-pol2qm74 2008 37 lra lra NNP cord-015021-pol2qm74 2008 38 ( ( -LRB- cord-015021-pol2qm74 2008 39 P p NN cord-015021-pol2qm74 2008 40 : : : cord-015021-pol2qm74 2008 41 16,9 16,9 CD cord-015021-pol2qm74 2008 42 % % NN cord-015021-pol2qm74 2008 43 -+1,9 -+1,9 : cord-015021-pol2qm74 2008 44 % % NN cord-015021-pol2qm74 2008 45 ; ; , cord-015021-pol2qm74 2008 46 p<0.001 p<0.001 CD cord-015021-pol2qm74 2008 47 , , , cord-015021-pol2qm74 2008 48 T t NN cord-015021-pol2qm74 2008 49 : : : cord-015021-pol2qm74 2008 50 28,8 28,8 CD cord-015021-pol2qm74 2008 51 % % NN cord-015021-pol2qm74 2008 52 -+3,6 -+3,6 CD cord-015021-pol2qm74 2008 53 % % NN cord-015021-pol2qm74 2008 54 , , , cord-015021-pol2qm74 2008 55 p<0.01 p<0.01 NNP cord-015021-pol2qm74 2008 56 , , , cord-015021-pol2qm74 2008 57 ANOVA ANOVA NNP cord-015021-pol2qm74 2008 58 ) ) -RRB- cord-015021-pol2qm74 2008 59 . . . cord-015021-pol2qm74 2009 1 Temporary temporary JJ cord-015021-pol2qm74 2009 2 adhesion adhesion NN cord-015021-pol2qm74 2009 3 of of IN cord-015021-pol2qm74 2009 4 leukocytes leukocyte NNS cord-015021-pol2qm74 2009 5 was be VBD cord-015021-pol2qm74 2009 6 unaffected unaffected JJ cord-015021-pol2qm74 2009 7 by by IN cord-015021-pol2qm74 2009 8 application application NN cord-015021-pol2qm74 2009 9 of of IN cord-015021-pol2qm74 2009 10 IL IL NNP cord-015021-pol2qm74 2009 11 - - HYPH cord-015021-pol2qm74 2009 12 lra lra NNP cord-015021-pol2qm74 2009 13 . . . cord-015021-pol2qm74 2010 1 Liver liver NN cord-015021-pol2qm74 2010 2 microcirculation microcirculation NN cord-015021-pol2qm74 2010 3 measured measure VBN cord-015021-pol2qm74 2010 4 by by IN cord-015021-pol2qm74 2010 5 volumetric volumetric JJ cord-015021-pol2qm74 2010 6 blood blood NN cord-015021-pol2qm74 2010 7 flow flow NN cord-015021-pol2qm74 2010 8 in in IN cord-015021-pol2qm74 2010 9 liver liver NN cord-015021-pol2qm74 2010 10 sinusoids sinusoid NNS cord-015021-pol2qm74 2010 11 and and CC cord-015021-pol2qm74 2010 12 sinusoidal sinusoidal JJ cord-015021-pol2qm74 2010 13 diameters diameter NNS cord-015021-pol2qm74 2010 14 was be VBD cord-015021-pol2qm74 2010 15 impaired impair VBN cord-015021-pol2qm74 2010 16 after after IN cord-015021-pol2qm74 2010 17 hemorrhagic hemorrhagic JJ cord-015021-pol2qm74 2010 18 shock shock NN cord-015021-pol2qm74 2010 19 in in IN cord-015021-pol2qm74 2010 20 all all DT cord-015021-pol2qm74 2010 21 groups group NNS cord-015021-pol2qm74 2010 22 and and CC cord-015021-pol2qm74 2010 23 was be VBD cord-015021-pol2qm74 2010 24 not not RB cord-015021-pol2qm74 2010 25 affected affect VBN cord-015021-pol2qm74 2011 1 ( ( -LRB- cord-015021-pol2qm74 2011 2 C C NNP cord-015021-pol2qm74 2011 3 : : : cord-015021-pol2qm74 2011 4 31993iam3 31993iam3 CD cord-015021-pol2qm74 2011 5 / / SYM cord-015021-pol2qm74 2011 6 s s NNP cord-015021-pol2qm74 2011 7 +40971um3 +40971um3 NNP cord-015021-pol2qm74 2011 8 / / SYM cord-015021-pol2qm74 2011 9 s s NNP cord-015021-pol2qm74 2011 10 , , , cord-015021-pol2qm74 2011 11 P p NN cord-015021-pol2qm74 2011 12 : : : cord-015021-pol2qm74 2012 1 32768llm3 32768llm3 NNP cord-015021-pol2qm74 2012 2 / / SYM cord-015021-pol2qm74 2012 3 s s POS cord-015021-pol2qm74 2012 4 +4445}am3 +4445}am3 NNP cord-015021-pol2qm74 2012 5 / / SYM cord-015021-pol2qm74 2012 6 s s NNP cord-015021-pol2qm74 2012 7 , , , cord-015021-pol2qm74 2012 8 T T NNP cord-015021-pol2qm74 2012 9 : : : cord-015021-pol2qm74 2012 10 326211amS 326211ams CD cord-015021-pol2qm74 2012 11 / / SYM cord-015021-pol2qm74 2012 12 s s NN cord-015021-pol2qm74 2013 1 -+2998 -+2998 JJ cord-015021-pol2qm74 2014 1 lam3 lam3 NNP cord-015021-pol2qm74 2014 2 / / SYM cord-015021-pol2qm74 2014 3 s s NNP cord-015021-pol2qm74 2014 4 , , , cord-015021-pol2qm74 2014 5 S S NNP cord-015021-pol2qm74 2014 6 : : : cord-015021-pol2qm74 2015 1 390201am3 390201am3 LS cord-015021-pol2qm74 2015 2 / / SYM cord-015021-pol2qm74 2015 3 s s POS cord-015021-pol2qm74 2015 4 -+39041am3 -+39041am3 NNP cord-015021-pol2qm74 2015 5 / / SYM cord-015021-pol2qm74 2015 6 s s NN cord-015021-pol2qm74 2015 7 ) ) -RRB- cord-015021-pol2qm74 2015 8 . . . cord-015021-pol2qm74 2016 1 Di.seu Di.seu NNP cord-015021-pol2qm74 2016 2 ~ ~ NNP cord-015021-pol2qm74 2016 3 sinn sinn NNP cord-015021-pol2qm74 2016 4 : : : cord-015021-pol2qm74 2016 5 The the DT cord-015021-pol2qm74 2016 6 results result NNS cord-015021-pol2qm74 2016 7 demonstrate demonstrate VBP cord-015021-pol2qm74 2016 8 that that IN cord-015021-pol2qm74 2016 9 permanent permanent JJ cord-015021-pol2qm74 2016 10 adherence adherence NN cord-015021-pol2qm74 2016 11 of of IN cord-015021-pol2qm74 2016 12 leukocytes leukocyte NNS cord-015021-pol2qm74 2016 13 to to IN cord-015021-pol2qm74 2016 14 endothelium endothelium NN cord-015021-pol2qm74 2016 15 is be VBZ cord-015021-pol2qm74 2016 16 in in IN cord-015021-pol2qm74 2016 17 part part NN cord-015021-pol2qm74 2016 18 regulated regulate VBN cord-015021-pol2qm74 2016 19 by by IN cord-015021-pol2qm74 2016 20 IL-1 IL-1 NNP cord-015021-pol2qm74 2016 21 . . . cord-015021-pol2qm74 2017 1 Pathological pathological JJ cord-015021-pol2qm74 2017 2 adherence adherence NN cord-015021-pol2qm74 2017 3 could could MD cord-015021-pol2qm74 2017 4 be be VB cord-015021-pol2qm74 2017 5 reduced reduce VBN cord-015021-pol2qm74 2017 6 by by IN cord-015021-pol2qm74 2017 7 application application NN cord-015021-pol2qm74 2017 8 of of IN cord-015021-pol2qm74 2017 9 ILlra ILlra NNP cord-015021-pol2qm74 2017 10 , , , cord-015021-pol2qm74 2017 11 even even RB cord-015021-pol2qm74 2017 12 given give VBN cord-015021-pol2qm74 2017 13 at at IN cord-015021-pol2qm74 2017 14 die die JJ cord-015021-pol2qm74 2017 15 time time NN cord-015021-pol2qm74 2017 16 of of IN cord-015021-pol2qm74 2017 17 resuscitation resuscitation NN cord-015021-pol2qm74 2017 18 . . . cord-015021-pol2qm74 2018 1 The the DT cord-015021-pol2qm74 2018 2 effect effect NN cord-015021-pol2qm74 2018 3 of of IN cord-015021-pol2qm74 2018 4 lL lL NNP cord-015021-pol2qm74 2018 5 - - HYPH cord-015021-pol2qm74 2018 6 lm lm NNP cord-015021-pol2qm74 2018 7 on on IN cord-015021-pol2qm74 2018 8 permanent permanent JJ cord-015021-pol2qm74 2018 9 adhesion adhesion NN cord-015021-pol2qm74 2018 10 is be VBZ cord-015021-pol2qm74 2018 11 a a DT cord-015021-pol2qm74 2018 12 specific specific JJ cord-015021-pol2qm74 2018 13 event event NN cord-015021-pol2qm74 2018 14 and and CC cord-015021-pol2qm74 2018 15 might may MD cord-015021-pol2qm74 2018 16 be be VB cord-015021-pol2qm74 2018 17 caused cause VBN cord-015021-pol2qm74 2018 18 by by IN cord-015021-pol2qm74 2018 19 reduced reduce VBN cord-015021-pol2qm74 2018 20 expression expression NN cord-015021-pol2qm74 2018 21 of of IN cord-015021-pol2qm74 2018 22 specific specific JJ cord-015021-pol2qm74 2018 23 receptors receptor NNS cord-015021-pol2qm74 2018 24 on on IN cord-015021-pol2qm74 2018 25 sinusoidal sinusoidal JJ cord-015021-pol2qm74 2018 26 endothelial endothelial JJ cord-015021-pol2qm74 2018 27 cens cen NNS cord-015021-pol2qm74 2018 28 and and CC cord-015021-pol2qm74 2018 29 leukocytes leukocyte NNS cord-015021-pol2qm74 2018 30 . . . cord-015021-pol2qm74 2019 1 Objectives objective NNS cord-015021-pol2qm74 2019 2 of of IN cord-015021-pol2qm74 2019 3 the the DT cord-015021-pol2qm74 2019 4 study study NN cord-015021-pol2qm74 2019 5 . . . cord-015021-pol2qm74 2020 1 The the DT cord-015021-pol2qm74 2020 2 adhesion adhesion NN cord-015021-pol2qm74 2020 3 of of IN cord-015021-pol2qm74 2020 4 activated activate VBN cord-015021-pol2qm74 2020 5 neutrophils neutrophil NNS cord-015021-pol2qm74 2020 6 ( ( -LRB- cord-015021-pol2qm74 2020 7 PMN PMN NNP cord-015021-pol2qm74 2020 8 ) ) -RRB- cord-015021-pol2qm74 2020 9 to to IN cord-015021-pol2qm74 2020 10 endothelial endothelial JJ cord-015021-pol2qm74 2020 11 ceils ceil NNS cord-015021-pol2qm74 2020 12 ( ( -LRB- cord-015021-pol2qm74 2020 13 EC EC NNP cord-015021-pol2qm74 2020 14 ) ) -RRB- cord-015021-pol2qm74 2020 15 and and CC cord-015021-pol2qm74 2020 16 the the DT cord-015021-pol2qm74 2020 17 concomitant concomitant JJ cord-015021-pol2qm74 2020 18 production production NN cord-015021-pol2qm74 2020 19 of of IN cord-015021-pol2qm74 2020 20 reactive reactive JJ cord-015021-pol2qm74 2020 21 oxygen oxygen NN cord-015021-pol2qm74 2020 22 metabolites metabolite NNS cord-015021-pol2qm74 2020 23 ( ( -LRB- cord-015021-pol2qm74 2020 24 ROM rom NN cord-015021-pol2qm74 2020 25 ) ) -RRB- cord-015021-pol2qm74 2020 26 initiates initiate VBZ cord-015021-pol2qm74 2020 27 organ organ NN cord-015021-pol2qm74 2020 28 damage damage NN cord-015021-pol2qm74 2020 29 after after IN cord-015021-pol2qm74 2020 30 trauma trauma NN cord-015021-pol2qm74 2020 31 , , , cord-015021-pol2qm74 2020 32 sepsis sepsis NN cord-015021-pol2qm74 2020 33 , , , cord-015021-pol2qm74 2020 34 shock shock NN cord-015021-pol2qm74 2020 35 and and CC cord-015021-pol2qm74 2020 36 organ organ NN cord-015021-pol2qm74 2020 37 reperfusion reperfusion NN cord-015021-pol2qm74 2020 38 . . . cord-015021-pol2qm74 2021 1 Aien Aien NNP cord-015021-pol2qm74 2021 2 of of IN cord-015021-pol2qm74 2021 3 this this DT cord-015021-pol2qm74 2021 4 study study NN cord-015021-pol2qm74 2021 5 was be VBD cord-015021-pol2qm74 2021 6 to to TO cord-015021-pol2qm74 2021 7 investigate investigate VB cord-015021-pol2qm74 2021 8 the the DT cord-015021-pol2qm74 2021 9 effect effect NN cord-015021-pol2qm74 2021 10 on on IN cord-015021-pol2qm74 2021 11 adhesion adhesion NN cord-015021-pol2qm74 2021 12 and and CC cord-015021-pol2qm74 2021 13 ROM rom NN cord-015021-pol2qm74 2021 14 production production NN cord-015021-pol2qm74 2021 15 of of IN cord-015021-pol2qm74 2021 16 the the DT cord-015021-pol2qm74 2021 17 highly highly RB cord-015021-pol2qm74 2021 18 water water NN cord-015021-pol2qm74 2021 19 - - HYPH cord-015021-pol2qm74 2021 20 soluble soluble JJ cord-015021-pol2qm74 2021 21 , , , cord-015021-pol2qm74 2021 22 membrane membrane NN cord-015021-pol2qm74 2021 23 - - HYPH cord-015021-pol2qm74 2021 24 permeable permeable JJ cord-015021-pol2qm74 2021 25 and and CC cord-015021-pol2qm74 2021 26 physiological physiological JJ cord-015021-pol2qm74 2021 27 ascorbic ascorbic NN cord-015021-pol2qm74 2021 28 acid acid NN cord-015021-pol2qm74 2021 29 ( ( -LRB- cord-015021-pol2qm74 2021 30 ASC ASC NNP cord-015021-pol2qm74 2021 31 ) ) -RRB- cord-015021-pol2qm74 2021 32 . . . cord-015021-pol2qm74 2022 1 Materials material NNS cord-015021-pol2qm74 2022 2 and and CC cord-015021-pol2qm74 2022 3 methods method NNS cord-015021-pol2qm74 2022 4 . . . cord-015021-pol2qm74 2023 1 Adhesion adhesion NN cord-015021-pol2qm74 2023 2 of of IN cord-015021-pol2qm74 2023 3 PMN PMN NNP cord-015021-pol2qm74 2023 4 to to TO cord-015021-pol2qm74 2023 5 nylon nylon VB cord-015021-pol2qm74 2023 6 fiber fiber NN cord-015021-pol2qm74 2023 7 ( ( -LRB- cord-015021-pol2qm74 2023 8 cell cell NN cord-015021-pol2qm74 2023 9 count count NN cord-015021-pol2qm74 2023 10 ) ) -RRB- cord-015021-pol2qm74 2023 11 and and CC cord-015021-pol2qm74 2023 12 simultaneous simultaneous JJ cord-015021-pol2qm74 2023 13 ROM rom NN cord-015021-pol2qm74 2023 14 production production NN cord-015021-pol2qm74 2023 15 ( ( -LRB- cord-015021-pol2qm74 2023 16 chemiluminescence chemiluminescence NNP cord-015021-pol2qm74 2023 17 - - HYPH cord-015021-pol2qm74 2023 18 CL cl NN cord-015021-pol2qm74 2023 19 - - HYPH cord-015021-pol2qm74 2023 20 response response NN cord-015021-pol2qm74 2023 21 ) ) -RRB- cord-015021-pol2qm74 2023 22 were be VBD cord-015021-pol2qm74 2023 23 measured measure VBN cord-015021-pol2qm74 2023 24 up up RP cord-015021-pol2qm74 2023 25 to to IN cord-015021-pol2qm74 2023 26 6 6 CD cord-015021-pol2qm74 2023 27 retool/1 retool/1 VBN cord-015021-pol2qm74 2023 28 ASC ASC NNP cord-015021-pol2qm74 2023 29 as as RB cord-015021-pol2qm74 2023 30 well well RB cord-015021-pol2qm74 2023 31 as as IN cord-015021-pol2qm74 2023 32 adhesion adhesion NN cord-015021-pol2qm74 2023 33 , , , cord-015021-pol2qm74 2023 34 ROM rom NN cord-015021-pol2qm74 2023 35 production production NN cord-015021-pol2qm74 2023 36 and and CC cord-015021-pol2qm74 2023 37 EC EC NNP cord-015021-pol2qm74 2023 38 damage damage NN cord-015021-pol2qm74 2023 39 ( ( -LRB- cord-015021-pol2qm74 2023 40 lllln lllln NNP cord-015021-pol2qm74 2023 41 - - HYPH cord-015021-pol2qm74 2023 42 release release NN cord-015021-pol2qm74 2023 43 from from IN cord-015021-pol2qm74 2023 44 labeled label VBN cord-015021-pol2qm74 2023 45 EC EC NNP cord-015021-pol2qm74 2023 46 ) ) -RRB- cord-015021-pol2qm74 2023 47 of of IN cord-015021-pol2qm74 2023 48 endotoxin endotoxin NN cord-015021-pol2qm74 2023 49 - - HYPH cord-015021-pol2qm74 2023 50 activated activate VBN cord-015021-pol2qm74 2023 51 PMN PMN NNP cord-015021-pol2qm74 2023 52 to to IN cord-015021-pol2qm74 2023 53 cultered cultere VBN cord-015021-pol2qm74 2023 54 EC EC NNP cord-015021-pol2qm74 2023 55 moanlayers moanlayer NNS cord-015021-pol2qm74 2023 56 . . . cord-015021-pol2qm74 2024 1 In in IN cord-015021-pol2qm74 2024 2 an an DT cord-015021-pol2qm74 2024 3 in in IN cord-015021-pol2qm74 2024 4 vivo vivo NN cord-015021-pol2qm74 2024 5 animal animal NN cord-015021-pol2qm74 2024 6 model model NN cord-015021-pol2qm74 2024 7 ( ( -LRB- cord-015021-pol2qm74 2024 8 sheep sheep NN cord-015021-pol2qm74 2024 9 with with IN cord-015021-pol2qm74 2024 10 lung lung NN cord-015021-pol2qm74 2024 11 lymph lymph NN cord-015021-pol2qm74 2024 12 fistulas fistula NNS cord-015021-pol2qm74 2024 13 ) ) -RRB- cord-015021-pol2qm74 2024 14 the the DT cord-015021-pol2qm74 2024 15 effect effect NN cord-015021-pol2qm74 2024 16 of of IN cord-015021-pol2qm74 2024 17 ASC ASC NNP cord-015021-pol2qm74 2024 18 ( ( -LRB- cord-015021-pol2qm74 2024 19 1 1 CD cord-015021-pol2qm74 2024 20 g g NN cord-015021-pol2qm74 2024 21 / / SYM cord-015021-pol2qm74 2024 22 kg kg NNP cord-015021-pol2qm74 2024 23 bw bw NNP cord-015021-pol2qm74 2024 24 bolus bolus NN cord-015021-pol2qm74 2024 25 , , , cord-015021-pol2qm74 2024 26 followed follow VBN cord-015021-pol2qm74 2024 27 by by IN cord-015021-pol2qm74 2024 28 0.2 0.2 CD cord-015021-pol2qm74 2024 29 g/ g/ NNP cord-015021-pol2qm74 2024 30 kg kg NNP cord-015021-pol2qm74 2024 31 - - HYPH cord-015021-pol2qm74 2024 32 h h NN cord-015021-pol2qm74 2024 33 infusion infusion NN cord-015021-pol2qm74 2024 34 ) ) -RRB- cord-015021-pol2qm74 2024 35 on on IN cord-015021-pol2qm74 2024 36 the the DT cord-015021-pol2qm74 2024 37 endotoxin endotoxin NN cord-015021-pol2qm74 2024 38 - - HYPH cord-015021-pol2qm74 2024 39 induced induce VBN cord-015021-pol2qm74 2024 40 ( ( -LRB- cord-015021-pol2qm74 2024 41 0.5 0.5 CD cord-015021-pol2qm74 2024 42 Ixg Ixg NNP cord-015021-pol2qm74 2024 43 / / SYM cord-015021-pol2qm74 2024 44 kg kg NNP cord-015021-pol2qm74 2024 45 bw bw NNP cord-015021-pol2qm74 2024 46 ) ) -RRB- cord-015021-pol2qm74 2024 47 neutropenia neutropenia NNP cord-015021-pol2qm74 2024 48 ( ( -LRB- cord-015021-pol2qm74 2024 49 cell cell NN cord-015021-pol2qm74 2024 50 count count NN cord-015021-pol2qm74 2024 51 ) ) -RRB- cord-015021-pol2qm74 2024 52 , , , cord-015021-pol2qm74 2024 53 lung lung NN cord-015021-pol2qm74 2024 54 capillary capillary JJ cord-015021-pol2qm74 2024 55 permeability permeability NN cord-015021-pol2qm74 2024 56 damage damage NN cord-015021-pol2qm74 2024 57 ( ( -LRB- cord-015021-pol2qm74 2024 58 lung lung NN cord-015021-pol2qm74 2024 59 lymph lymph NN cord-015021-pol2qm74 2024 60 protein protein NN cord-015021-pol2qm74 2024 61 clearance clearance NN cord-015021-pol2qm74 2024 62 ) ) -RRB- cord-015021-pol2qm74 2024 63 and and CC cord-015021-pol2qm74 2024 64 ROM rom NN cord-015021-pol2qm74 2024 65 production production NN cord-015021-pol2qm74 2024 66 of of IN cord-015021-pol2qm74 2024 67 neutrophils neutrophil NNS cord-015021-pol2qm74 2024 68 ( ( -LRB- cord-015021-pol2qm74 2024 69 zymosan zymosan NNP cord-015021-pol2qm74 2024 70 - - HYPH cord-015021-pol2qm74 2024 71 induced induce VBN cord-015021-pol2qm74 2024 72 CL CL NNP cord-015021-pol2qm74 2024 73 response response NN cord-015021-pol2qm74 2024 74 ) ) -RRB- cord-015021-pol2qm74 2024 75 was be VBD cord-015021-pol2qm74 2024 76 measured measure VBN cord-015021-pol2qm74 2024 77 . . . cord-015021-pol2qm74 2025 1 Results result NNS cord-015021-pol2qm74 2025 2 . . . cord-015021-pol2qm74 2026 1 ASC ASC NNP cord-015021-pol2qm74 2026 2 scavenged scavenge VBD cord-015021-pol2qm74 2026 3 ROM rom NN cord-015021-pol2qm74 2026 4 dose dose NN cord-015021-pol2qm74 2026 5 - - : cord-015021-pol2qm74 2026 6 dependently dependently RB cord-015021-pol2qm74 2026 7 during during IN cord-015021-pol2qm74 2026 8 adhesion adhesion NN cord-015021-pol2qm74 2026 9 of of IN cord-015021-pol2qm74 2026 10 PMN PMN NNP cord-015021-pol2qm74 2026 11 to to TO cord-015021-pol2qm74 2026 12 nylon nylon VB cord-015021-pol2qm74 2026 13 fiber fiber NN cord-015021-pol2qm74 2026 14 ( ( -LRB- cord-015021-pol2qm74 2026 15 p<0.0005 p<0.0005 CC cord-015021-pol2qm74 2026 16 at at IN cord-015021-pol2qm74 2026 17 6 6 CD cord-015021-pol2qm74 2026 18 mmol mmol JJ cord-015021-pol2qm74 2026 19 / / SYM cord-015021-pol2qm74 2026 20 l l NNP cord-015021-pol2qm74 2026 21 ASC ASC NNP cord-015021-pol2qm74 2026 22 ) ) -RRB- cord-015021-pol2qm74 2026 23 , , , cord-015021-pol2qm74 2026 24 adhesion adhesion NN cord-015021-pol2qm74 2026 25 itself -PRON- PRP cord-015021-pol2qm74 2026 26 was be VBD cord-015021-pol2qm74 2026 27 unchanged unchanged JJ cord-015021-pol2qm74 2026 28 . . . cord-015021-pol2qm74 2027 1 During during IN cord-015021-pol2qm74 2027 2 the the DT cord-015021-pol2qm74 2027 3 activated activate VBN cord-015021-pol2qm74 2027 4 PMN PMN NNP cord-015021-pol2qm74 2027 5 / / SYM cord-015021-pol2qm74 2027 6 EC EC NNP cord-015021-pol2qm74 2027 7 interaction interaction NN cord-015021-pol2qm74 2027 8 ASC ASC NNP cord-015021-pol2qm74 2027 9 scavenged scavenge VBD cord-015021-pol2qm74 2027 10 ROM rom NN cord-015021-pol2qm74 2027 11 ( ( -LRB- cord-015021-pol2qm74 2027 12 p<0.025 p<0.025 NNP cord-015021-pol2qm74 2027 13 at at IN cord-015021-pol2qm74 2027 14 6 6 CD cord-015021-pol2qm74 2027 15 mmol mmol JJ cord-015021-pol2qm74 2027 16 / / SYM cord-015021-pol2qm74 2027 17 l l NNP cord-015021-pol2qm74 2027 18 ASC ASC NNP cord-015021-pol2qm74 2027 19 ) ) -RRB- cord-015021-pol2qm74 2027 20 and and CC cord-015021-pol2qm74 2027 21 reduced reduce VBD cord-015021-pol2qm74 2027 22 the the DT cord-015021-pol2qm74 2027 23 adhesion adhesion NN cord-015021-pol2qm74 2027 24 dose dose NN cord-015021-pol2qm74 2027 25 - - : cord-015021-pol2qm74 2027 26 dependently dependently RB cord-015021-pol2qm74 2027 27 ( ( -LRB- cord-015021-pol2qm74 2027 28 p<0.0005 p<0.0005 CC cord-015021-pol2qm74 2027 29 at at IN cord-015021-pol2qm74 2027 30 6 6 CD cord-015021-pol2qm74 2027 31 mmol mmol JJ cord-015021-pol2qm74 2027 32 / / SYM cord-015021-pol2qm74 2027 33 l l NNP cord-015021-pol2qm74 2027 34 ASC ASC NNP cord-015021-pol2qm74 2027 35 ) ) -RRB- cord-015021-pol2qm74 2027 36 ; ; : cord-015021-pol2qm74 2027 37 EC EC NNP cord-015021-pol2qm74 2027 38 damage damage NN cord-015021-pol2qm74 2027 39 was be VBD cord-015021-pol2qm74 2027 40 also also RB cord-015021-pol2qm74 2027 41 reduced reduce VBN cord-015021-pol2qm74 2027 42 ( ( -LRB- cord-015021-pol2qm74 2027 43 p<0.0005 p<0.0005 CC cord-015021-pol2qm74 2027 44 at at IN cord-015021-pol2qm74 2027 45 6 6 CD cord-015021-pol2qm74 2027 46 retool/1 retool/1 VBN cord-015021-pol2qm74 2027 47 ASC ASC NNP cord-015021-pol2qm74 2027 48 ) ) -RRB- cord-015021-pol2qm74 2027 49 . . . cord-015021-pol2qm74 2028 1 In in IN cord-015021-pol2qm74 2028 2 the the DT cord-015021-pol2qm74 2028 3 in in IN cord-015021-pol2qm74 2028 4 rive rive NNP cord-015021-pol2qm74 2028 5 model model NN cord-015021-pol2qm74 2028 6 ASC ASC NNP cord-015021-pol2qm74 2028 7 increased increase VBD cord-015021-pol2qm74 2028 8 the the DT cord-015021-pol2qm74 2028 9 endotoxin endotoxin NN cord-015021-pol2qm74 2028 10 - - HYPH cord-015021-pol2qm74 2028 11 induced induce VBN cord-015021-pol2qm74 2028 12 blood blood NN cord-015021-pol2qm74 2028 13 PMN PMN NNP cord-015021-pol2qm74 2028 14 decrease decrease NN cord-015021-pol2qm74 2028 15 ( ( -LRB- cord-015021-pol2qm74 2028 16 p<0.05 p<0.05 CD cord-015021-pol2qm74 2028 17 ) ) -RRB- cord-015021-pol2qm74 2028 18 , , , cord-015021-pol2qm74 2028 19 decreased decrease VBD cord-015021-pol2qm74 2028 20 the the DT cord-015021-pol2qm74 2028 21 protein protein NN cord-015021-pol2qm74 2028 22 clearance clearance NN cord-015021-pol2qm74 2028 23 ( ( -LRB- cord-015021-pol2qm74 2028 24 p<0.05 p<0.05 CD cord-015021-pol2qm74 2028 25 ) ) -RRB- cord-015021-pol2qm74 2028 26 as as RB cord-015021-pol2qm74 2028 27 well well RB cord-015021-pol2qm74 2028 28 as as IN cord-015021-pol2qm74 2028 29 the the DT cord-015021-pol2qm74 2028 30 zymosan zymosan NNP cord-015021-pol2qm74 2028 31 - - HYPH cord-015021-pol2qm74 2028 32 induced induce VBN cord-015021-pol2qm74 2028 33 ROM rom NN cord-015021-pol2qm74 2028 34 production production NN cord-015021-pol2qm74 2028 35 ( ( -LRB- cord-015021-pol2qm74 2028 36 p<0.03 p<0.03 NN cord-015021-pol2qm74 2028 37 ) ) -RRB- cord-015021-pol2qm74 2028 38 , , , cord-015021-pol2qm74 2028 39 indicating indicate VBG cord-015021-pol2qm74 2028 40 the the DT cord-015021-pol2qm74 2028 41 ASC ASC NNP cord-015021-pol2qm74 2028 42 - - HYPH cord-015021-pol2qm74 2028 43 mediated mediate VBN cord-015021-pol2qm74 2028 44 reduction reduction NN cord-015021-pol2qm74 2028 45 of of IN cord-015021-pol2qm74 2028 46 adhesion adhesion NN cord-015021-pol2qm74 2028 47 , , , cord-015021-pol2qm74 2028 48 ROM rom NN cord-015021-pol2qm74 2028 49 production production NN cord-015021-pol2qm74 2028 50 and and CC cord-015021-pol2qm74 2028 51 lung lung NN cord-015021-pol2qm74 2028 52 tissue tissue NN cord-015021-pol2qm74 2028 53 damage damage NN cord-015021-pol2qm74 2028 54 processes process NNS cord-015021-pol2qm74 2028 55 . . . cord-015021-pol2qm74 2029 1 Conclusions conclusion NNS cord-015021-pol2qm74 2029 2 . . . cord-015021-pol2qm74 2030 1 By by IN cord-015021-pol2qm74 2030 2 in in IN cord-015021-pol2qm74 2030 3 vitro vitro FW cord-015021-pol2qm74 2030 4 and and CC cord-015021-pol2qm74 2030 5 in in IN cord-015021-pol2qm74 2030 6 rive rive NNP cord-015021-pol2qm74 2030 7 experiments experiment NNS cord-015021-pol2qm74 2030 8 ascorbic ascorbic NN cord-015021-pol2qm74 2030 9 acid acid NN cord-015021-pol2qm74 2030 10 reduced reduce VBD cord-015021-pol2qm74 2030 11 the the DT cord-015021-pol2qm74 2030 12 adhesion adhesion NN cord-015021-pol2qm74 2030 13 - - HYPH cord-015021-pol2qm74 2030 14 and and CC cord-015021-pol2qm74 2030 15 ROM rom NN cord-015021-pol2qm74 2030 16 production production NN cord-015021-pol2qm74 2030 17 - - HYPH cord-015021-pol2qm74 2030 18 initiated initiate VBN cord-015021-pol2qm74 2030 19 tissue tissue NN cord-015021-pol2qm74 2030 20 damage damage NN cord-015021-pol2qm74 2030 21 . . . cord-015021-pol2qm74 2031 1 Therefore therefore RB cord-015021-pol2qm74 2031 2 , , , cord-015021-pol2qm74 2031 3 i.v i.v NNP cord-015021-pol2qm74 2031 4 . . NNP cord-015021-pol2qm74 2031 5 administration administration NN cord-015021-pol2qm74 2031 6 of of IN cord-015021-pol2qm74 2031 7 ascorbic ascorbic NNP cord-015021-pol2qm74 2031 8 acid acid NN cord-015021-pol2qm74 2031 9 is be VBZ cord-015021-pol2qm74 2031 10 recommended recommend VBN cord-015021-pol2qm74 2031 11 for for IN cord-015021-pol2qm74 2031 12 oxidative oxidative JJ cord-015021-pol2qm74 2031 13 stress stress NN cord-015021-pol2qm74 2031 14 - - HYPH cord-015021-pol2qm74 2031 15 associated associate VBN cord-015021-pol2qm74 2031 16 states state NNS cord-015021-pol2qm74 2031 17 after after IN cord-015021-pol2qm74 2031 18 trauma trauma NN cord-015021-pol2qm74 2031 19 , , , cord-015021-pol2qm74 2031 20 sepsis sepsis NN cord-015021-pol2qm74 2031 21 , , , cord-015021-pol2qm74 2031 22 shock shock NN cord-015021-pol2qm74 2031 23 and and CC cord-015021-pol2qm74 2031 24 organ organ NN cord-015021-pol2qm74 2031 25 reperfusion reperfusion NN cord-015021-pol2qm74 2031 26 . . . cord-015021-pol2qm74 2032 1 for for IN cord-015021-pol2qm74 2032 2 neut neut NNP cord-015021-pol2qm74 2032 3 rophi rophi NNP cord-015021-pol2qm74 2032 4 l l NNP cord-015021-pol2qm74 2032 5 - - HYPH cord-015021-pol2qm74 2032 6 accumulat accumulat NNP cord-015021-pol2qm74 2032 7 ion ion NN cord-015021-pol2qm74 2032 8 and and CC cord-015021-pol2qm74 2032 9 activation activation NN cord-015021-pol2qm74 2032 10 . . . cord-015021-pol2qm74 2033 1 We -PRON- PRP cord-015021-pol2qm74 2033 2 investigated investigate VBD cord-015021-pol2qm74 2033 3 the the DT cord-015021-pol2qm74 2033 4 influence influence NN cord-015021-pol2qm74 2033 5 of of IN cord-015021-pol2qm74 2033 6 OR or CC cord-015021-pol2qm74 2033 7 to to IN cord-015021-pol2qm74 2033 8 the the DT cord-015021-pol2qm74 2033 9 activation activation NN cord-015021-pol2qm74 2033 10 and and CC cord-015021-pol2qm74 2033 11 the the DT cord-015021-pol2qm74 2033 12 expression expression NN cord-015021-pol2qm74 2033 13 of of IN cord-015021-pol2qm74 2033 14 LECAM LECAM NNP cord-015021-pol2qm74 2033 15 - - : cord-015021-pol2qm74 2033 16 I I NNP cord-015021-pol2qm74 2033 17 and and CC cord-015021-pol2qm74 2033 18 CDIIb CDIIb NNS cord-015021-pol2qm74 2033 19 , , , cord-015021-pol2qm74 2033 20 CDI8 CDI8 NNP cord-015021-pol2qm74 2033 21 on on IN cord-015021-pol2qm74 2033 22 neutrophils neutrophil NNS cord-015021-pol2qm74 2033 23 and and CC cord-015021-pol2qm74 2033 24 lymphocytes lymphocyte NNS cord-015021-pol2qm74 2033 25 . . . cord-015021-pol2qm74 2034 1 Methods method NNS cord-015021-pol2qm74 2034 2 : : : cord-015021-pol2qm74 2035 1 From from IN cord-015021-pol2qm74 2035 2 blood blood NN cord-015021-pol2qm74 2035 3 samples sample NNS cord-015021-pol2qm74 2035 4 ( ( -LRB- cord-015021-pol2qm74 2035 5 n=5 n=5 RB cord-015021-pol2qm74 2035 6 ) ) -RRB- cord-015021-pol2qm74 2036 1 all all DT cord-015021-pol2qm74 2036 2 white white JJ cord-015021-pol2qm74 2036 3 blood blood NN cord-015021-pol2qm74 2036 4 cells cell NNS cord-015021-pol2qm74 2036 5 ( ( -LRB- cord-015021-pol2qm74 2036 6 WBC WBC NNP cord-015021-pol2qm74 2036 7 ) ) -RRB- cord-015021-pol2qm74 2036 8 and and CC cord-015021-pol2qm74 2036 9 neutrophils neutrophil NNS cord-015021-pol2qm74 2036 10 ( ( -LRB- cord-015021-pol2qm74 2036 11 NC NC NNP cord-015021-pol2qm74 2036 12 ) ) -RRB- cord-015021-pol2qm74 2036 13 were be VBD cord-015021-pol2qm74 2036 14 isolated isolate VBN cord-015021-pol2qm74 2036 15 and and CC cord-015021-pol2qm74 2036 16 cultured cultured JJ cord-015021-pol2qm74 2036 17 . . . cord-015021-pol2qm74 2037 1 OR or CC cord-015021-pol2qm74 2037 2 were be VBD cord-015021-pol2qm74 2037 3 produced produce VBN cord-015021-pol2qm74 2037 4 via via IN cord-015021-pol2qm74 2037 5 the the DT cord-015021-pol2qm74 2037 6 xanthine xanthine NN cord-015021-pol2qm74 2037 7 oxidase oxidase NN cord-015021-pol2qm74 2037 8 / / SYM cord-015021-pol2qm74 2037 9 hypoxanthine hypoxanthine NN cord-015021-pol2qm74 2037 10 system system NN cord-015021-pol2qm74 2037 11 . . . cord-015021-pol2qm74 2038 1 After after IN cord-015021-pol2qm74 2038 2 0,5 0,5 CD cord-015021-pol2qm74 2038 3 , , , cord-015021-pol2qm74 2038 4 15,30,60 15,30,60 CD cord-015021-pol2qm74 2038 5 and and CC cord-015021-pol2qm74 2038 6 120 120 CD cord-015021-pol2qm74 2038 7 minutes minute NNS cord-015021-pol2qm74 2038 8 a a DT cord-015021-pol2qm74 2038 9 Giemsa Giemsa NNP cord-015021-pol2qm74 2038 10 - - HYPH cord-015021-pol2qm74 2038 11 staining staining NN cord-015021-pol2qm74 2038 12 to to TO cord-015021-pol2qm74 2038 13 determine determine VB cord-015021-pol2qm74 2038 14 the the DT cord-015021-pol2qm74 2038 15 granulation granulation NN cord-015021-pol2qm74 2038 16 of of IN cord-015021-pol2qm74 2038 17 neutrophils neutrophil NNS cord-015021-pol2qm74 2038 18 ( ( -LRB- cord-015021-pol2qm74 2038 19 n n CC cord-015021-pol2qm74 2038 20 : : : cord-015021-pol2qm74 2038 21 normal normal JJ cord-015021-pol2qm74 2038 22 , , , cord-015021-pol2qm74 2038 23 r r NN cord-015021-pol2qm74 2038 24 : : : cord-015021-pol2qm74 2038 25 reduced reduce VBN cord-015021-pol2qm74 2038 26 ) ) -RRB- cord-015021-pol2qm74 2038 27 and and CC cord-015021-pol2qm74 2038 28 a a DT cord-015021-pol2qm74 2038 29 FACS FACS NNP cord-015021-pol2qm74 2038 30 - - HYPH cord-015021-pol2qm74 2038 31 analysis analysis NN cord-015021-pol2qm74 2038 32 with with IN cord-015021-pol2qm74 2038 33 monoclonal monoclonal JJ cord-015021-pol2qm74 2038 34 antibodies antibody NNS cord-015021-pol2qm74 2038 35 detecting detect VBG cord-015021-pol2qm74 2038 36 CDIIb CDIIb NNS cord-015021-pol2qm74 2038 37 , , , cord-015021-pol2qm74 2038 38 CDI8 CDI8 NNP cord-015021-pol2qm74 2038 39 and and CC cord-015021-pol2qm74 2038 40 LECAM LECAM NNP cord-015021-pol2qm74 2038 41 - - : cord-015021-pol2qm74 2038 42 I -PRON- PRP cord-015021-pol2qm74 2038 43 was be VBD cord-015021-pol2qm74 2038 44 performed perform VBN cord-015021-pol2qm74 2038 45 . . . cord-015021-pol2qm74 2039 1 Results result NNS cord-015021-pol2qm74 2039 2 : : : cord-015021-pol2qm74 2040 1 under under IN cord-015021-pol2qm74 2040 2 the the DT cord-015021-pol2qm74 2040 3 influence influence NN cord-015021-pol2qm74 2040 4 of of IN cord-015021-pol2qm74 2040 5 OR or CC cord-015021-pol2qm74 2040 6 a a DT cord-015021-pol2qm74 2040 7 degranulation degranulation NN cord-015021-pol2qm74 2040 8 of of IN cord-015021-pol2qm74 2040 9 neutrophils neutrophil NNS cord-015021-pol2qm74 2040 10 starting start VBG cord-015021-pol2qm74 2040 11 at at IN cord-015021-pol2qm74 2040 12 15min 15min NNP cord-015021-pol2qm74 2040 13 was be VBD cord-015021-pol2qm74 2040 14 observed observe VBN cord-015021-pol2qm74 2040 15 in in IN cord-015021-pol2qm74 2040 16 WBC WBC NNP cord-015021-pol2qm74 2040 17 - - HYPH cord-015021-pol2qm74 2040 18 cultures culture NNS cord-015021-pol2qm74 2040 19 ( ( -LRB- cord-015021-pol2qm74 2040 20 n n NN cord-015021-pol2qm74 2040 21 / / SYM cord-015021-pol2qm74 2040 22 r r NN cord-015021-pol2qm74 2040 23 : : : cord-015021-pol2qm74 2040 24 0min 0min CD cord-015021-pol2qm74 2040 25 91/9 91/9 CD cord-015021-pol2qm74 2040 26 , , , cord-015021-pol2qm74 2040 27 15min 15min NNP cord-015021-pol2qm74 2040 28 76/24 76/24 CD cord-015021-pol2qm74 2040 29 , , , cord-015021-pol2qm74 2040 30 30min 30min NN cord-015021-pol2qm74 2040 31 68/32 68/32 CD cord-015021-pol2qm74 2040 32 , , , cord-015021-pol2qm74 2040 33 60min 60min JJ cord-015021-pol2qm74 2040 34 52/48 52/48 CD cord-015021-pol2qm74 2040 35 , , , cord-015021-pol2qm74 2040 36 120min 120min CD cord-015021-pol2qm74 2040 37 49/51 49/51 CD cord-015021-pol2qm74 2040 38 ) ) -RRB- cord-015021-pol2qm74 2040 39 . . . cord-015021-pol2qm74 2041 1 These these DT cord-015021-pol2qm74 2041 2 data datum NNS cord-015021-pol2qm74 2041 3 were be VBD cord-015021-pol2qm74 2041 4 confirmed confirm VBN cord-015021-pol2qm74 2041 5 in in IN cord-015021-pol2qm74 2041 6 the the DT cord-015021-pol2qm74 2041 7 dot dot NN cord-015021-pol2qm74 2041 8 - - HYPH cord-015021-pol2qm74 2041 9 plots plot NNS cord-015021-pol2qm74 2041 10 of of IN cord-015021-pol2qm74 2041 11 FACS FACS NNP cord-015021-pol2qm74 2041 12 - - HYPH cord-015021-pol2qm74 2041 13 analysis analysis NN cord-015021-pol2qm74 2041 14 . . . cord-015021-pol2qm74 2042 1 Only only RB cord-015021-pol2qm74 2042 2 in in IN cord-015021-pol2qm74 2042 3 WBC WBC NNP cord-015021-pol2qm74 2042 4 - - HYPH cord-015021-pol2qm74 2042 5 cultures culture NNS cord-015021-pol2qm74 2042 6 OR or CC cord-015021-pol2qm74 2042 7 induced induce VBD cord-015021-pol2qm74 2042 8 a a DT cord-015021-pol2qm74 2042 9 significant significant JJ cord-015021-pol2qm74 2042 10 increase increase NN cord-015021-pol2qm74 2042 11 of of IN cord-015021-pol2qm74 2042 12 LECAM LECAM NNP cord-015021-pol2qm74 2042 13 - - : cord-015021-pol2qm74 2042 14 I -PRON- PRP cord-015021-pol2qm74 2042 15 expression expression NN cord-015021-pol2qm74 2042 16 on on IN cord-015021-pol2qm74 2042 17 neutrophils neutrophil NNS cord-015021-pol2qm74 2042 18 up up RP cord-015021-pol2qm74 2042 19 to to IN cord-015021-pol2qm74 2042 20 30min 30min NN cord-015021-pol2qm74 2042 21 followed follow VBN cord-015021-pol2qm74 2042 22 by by IN cord-015021-pol2qm74 2042 23 a a DT cord-015021-pol2qm74 2042 24 decrease decrease NN cord-015021-pol2qm74 2042 25 to to IN cord-015021-pol2qm74 2042 26 normal normal JJ cord-015021-pol2qm74 2042 27 values value NNS cord-015021-pol2qm74 2042 28 at at IN cord-015021-pol2qm74 2042 29 60min 60min NN cord-015021-pol2qm74 2042 30 . . . cord-015021-pol2qm74 2043 1 LECAM LECAM NNP cord-015021-pol2qm74 2043 2 - - : cord-015021-pol2qm74 2043 3 I -PRON- PRP cord-015021-pol2qm74 2043 4 on on IN cord-015021-pol2qm74 2043 5 lymphocytes lymphocyte NNS cord-015021-pol2qm74 2043 6 disappeared disappear VBD cord-015021-pol2qm74 2043 7 totally totally RB cord-015021-pol2qm74 2043 8 during during IN cord-015021-pol2qm74 2043 9 the the DT cord-015021-pol2qm74 2043 10 observed observed JJ cord-015021-pol2qm74 2043 11 period period NN cord-015021-pol2qm74 2043 12 . . . cord-015021-pol2qm74 2044 1 CDllb CDllb NNP cord-015021-pol2qm74 2044 2 , , , cord-015021-pol2qm74 2044 3 CDl8-expression CDl8-expression NNP cord-015021-pol2qm74 2044 4 was be VBD cord-015021-pol2qm74 2044 5 not not RB cord-015021-pol2qm74 2044 6 altered alter VBN cord-015021-pol2qm74 2044 7 . . . cord-015021-pol2qm74 2045 1 Conclusion conclusion NN cord-015021-pol2qm74 2045 2 : : : cord-015021-pol2qm74 2046 1 Increased increase VBN cord-015021-pol2qm74 2046 2 LECAM LECAM NNP cord-015021-pol2qm74 2046 3 - - : cord-015021-pol2qm74 2046 4 I -PRON- PRP cord-015021-pol2qm74 2046 5 expression expression NN cord-015021-pol2qm74 2046 6 on on IN cord-015021-pol2qm74 2046 7 neutrophils neutrophil NNS cord-015021-pol2qm74 2046 8 due due IN cord-015021-pol2qm74 2046 9 to to IN cord-015021-pol2qm74 2046 10 OR or CC cord-015021-pol2qm74 2046 11 could could MD cord-015021-pol2qm74 2046 12 enhance enhance VB cord-015021-pol2qm74 2046 13 the the DT cord-015021-pol2qm74 2046 14 ' ' `` cord-015021-pol2qm74 2046 15 rolling rolling NN cord-015021-pol2qm74 2046 16 ' ' '' cord-015021-pol2qm74 2046 17 of of IN cord-015021-pol2qm74 2046 18 neutrophils neutrophil NNS cord-015021-pol2qm74 2046 19 along along IN cord-015021-pol2qm74 2046 20 the the DT cord-015021-pol2qm74 2046 21 endothelium endothelium NN cord-015021-pol2qm74 2046 22 which which WDT cord-015021-pol2qm74 2046 23 is be VBZ cord-015021-pol2qm74 2046 24 a a DT cord-015021-pol2qm74 2046 25 prerequisite prerequisite NN cord-015021-pol2qm74 2046 26 for for IN cord-015021-pol2qm74 2046 27 neutrophil neutrophil NN cord-015021-pol2qm74 2046 28 sticking sticking NN cord-015021-pol2qm74 2046 29 and and CC cord-015021-pol2qm74 2046 30 migration migration NN cord-015021-pol2qm74 2046 31 . . . cord-015021-pol2qm74 2047 1 Further further JJ cord-015021-pol2qm74 2047 2 OR or CC cord-015021-pol2qm74 2047 3 are be VBP cord-015021-pol2qm74 2047 4 able able JJ cord-015021-pol2qm74 2047 5 to to TO cord-015021-pol2qm74 2047 6 activate activate VB cord-015021-pol2qm74 2047 7 neutrophils neutrophil NNS cord-015021-pol2qm74 2047 8 without without IN cord-015021-pol2qm74 2047 9 endothelium endothelium NN cord-015021-pol2qm74 2047 10 . . . cord-015021-pol2qm74 2048 1 These these DT cord-015021-pol2qm74 2048 2 changes change NNS cord-015021-pol2qm74 2048 3 seem seem VBP cord-015021-pol2qm74 2048 4 to to TO cord-015021-pol2qm74 2048 5 be be VB cord-015021-pol2qm74 2048 6 mediated mediate VBN cord-015021-pol2qm74 2048 7 by by IN cord-015021-pol2qm74 2048 8 other other JJ cord-015021-pol2qm74 2048 9 WBC WBC NNP cord-015021-pol2qm74 2048 10 . . . cord-015021-pol2qm74 2049 1 Introduction introduction NN cord-015021-pol2qm74 2049 2 . . . cord-015021-pol2qm74 2050 1 Multiple multiple JJ cord-015021-pol2qm74 2050 2 Organ Organ NNP cord-015021-pol2qm74 2050 3 Failure failure NN cord-015021-pol2qm74 2050 4 ( ( -LRB- cord-015021-pol2qm74 2050 5 MOF MOF NNP cord-015021-pol2qm74 2050 6 ) ) -RRB- cord-015021-pol2qm74 2050 7 has have VBZ cord-015021-pol2qm74 2050 8 been be VBN cord-015021-pol2qm74 2050 9 hypothesized hypothesize VBN cord-015021-pol2qm74 2050 10 to to TO cord-015021-pol2qm74 2050 11 be be VB cord-015021-pol2qm74 2050 12 the the DT cord-015021-pol2qm74 2050 13 result result NN cord-015021-pol2qm74 2050 14 of of IN cord-015021-pol2qm74 2050 15 an an DT cord-015021-pol2qm74 2050 16 excessive excessive JJ cord-015021-pol2qm74 2050 17 uncontrolled uncontrolled JJ cord-015021-pol2qm74 2050 18 autedestructive autedestructive JJ cord-015021-pol2qm74 2050 19 inflammatory inflammatory JJ cord-015021-pol2qm74 2050 20 response response NN cord-015021-pol2qm74 2050 21 . . . cord-015021-pol2qm74 2051 1 Since since IN cord-015021-pol2qm74 2051 2 the the DT cord-015021-pol2qm74 2051 3 complement complement NN cord-015021-pol2qm74 2051 4 system system NN cord-015021-pol2qm74 2051 5 is be VBZ cord-015021-pol2qm74 2051 6 an an DT cord-015021-pol2qm74 2051 7 important important JJ cord-015021-pol2qm74 2051 8 mediator mediator NN cord-015021-pol2qm74 2051 9 and and CC cord-015021-pol2qm74 2051 10 initiator initiator NN cord-015021-pol2qm74 2051 11 of of IN cord-015021-pol2qm74 2051 12 the the DT cord-015021-pol2qm74 2051 13 inflammatory inflammatory JJ cord-015021-pol2qm74 2051 14 response response NN cord-015021-pol2qm74 2051 15 , , , cord-015021-pol2qm74 2051 16 interruption interruption NN cord-015021-pol2qm74 2051 17 of of IN cord-015021-pol2qm74 2051 18 this this DT cord-015021-pol2qm74 2051 19 cascade cascade NN cord-015021-pol2qm74 2051 20 could could MD cord-015021-pol2qm74 2051 21 theoretically theoretically RB cord-015021-pol2qm74 2051 22 lead lead VB cord-015021-pol2qm74 2051 23 to to IN cord-015021-pol2qm74 2051 24 an an DT cord-015021-pol2qm74 2051 25 attenuation attenuation NN cord-015021-pol2qm74 2051 26 of of IN cord-015021-pol2qm74 2051 27 MOF MOF NNP cord-015021-pol2qm74 2051 28 . . . cord-015021-pol2qm74 2052 1 In in IN cord-015021-pol2qm74 2052 2 order order NN cord-015021-pol2qm74 2052 3 to to TO cord-015021-pol2qm74 2052 4 test test VB cord-015021-pol2qm74 2052 5 this this DT cord-015021-pol2qm74 2052 6 hypothesis hypothesis NN cord-015021-pol2qm74 2052 7 we -PRON- PRP cord-015021-pol2qm74 2052 8 evaluated evaluate VBD cord-015021-pol2qm74 2052 9 the the DT cord-015021-pol2qm74 2052 10 response response NN cord-015021-pol2qm74 2052 11 of of IN cord-015021-pol2qm74 2052 12 C5-delicient c5-delicient NN cord-015021-pol2qm74 2052 13 mice mouse NNS cord-015021-pol2qm74 2052 14 in in IN cord-015021-pol2qm74 2052 15 a a DT cord-015021-pol2qm74 2052 16 model model NN cord-015021-pol2qm74 2052 17 of of IN cord-015021-pol2qm74 2052 18 zymesan zymesan NNP cord-015021-pol2qm74 2052 19 indt indt NNP cord-015021-pol2qm74 2052 20 ~ ~ NFP cord-015021-pol2qm74 2052 21 ed ed NNP cord-015021-pol2qm74 2052 22 MOF MOF NNP cord-015021-pol2qm74 2052 23 . . . cord-015021-pol2qm74 2053 1 Materials material NNS cord-015021-pol2qm74 2053 2 and and CC cord-015021-pol2qm74 2053 3 Methods method NNS cord-015021-pol2qm74 2053 4 . . . cord-015021-pol2qm74 2054 1 25 25 CD cord-015021-pol2qm74 2054 2 C5-deficient c5-deficient NN cord-015021-pol2qm74 2054 3 B2D10 B2D10 NNP cord-015021-pol2qm74 2054 4 / / SYM cord-015021-pol2qm74 2054 5 OId OId NNS cord-015021-pol2qm74 2054 6 and and CC cord-015021-pol2qm74 2054 7 25 25 CD cord-015021-pol2qm74 2054 8 C5-sufficient c5-sufficient NN cord-015021-pol2qm74 2054 9 B2D10/ B2D10/ NNS cord-015021-pol2qm74 2055 1 New new JJ cord-015021-pol2qm74 2055 2 mice mouse NNS cord-015021-pol2qm74 2055 3 were be VBD cord-015021-pol2qm74 2055 4 used use VBN cord-015021-pol2qm74 2055 5 in in IN cord-015021-pol2qm74 2055 6 this this DT cord-015021-pol2qm74 2055 7 study study NN cord-015021-pol2qm74 2055 8 . . . cord-015021-pol2qm74 2056 1 On on IN cord-015021-pol2qm74 2056 2 day day NN cord-015021-pol2qm74 2056 3 0 0 NFP cord-015021-pol2qm74 2056 4 all all DT cord-015021-pol2qm74 2056 5 mice mouse NNS cord-015021-pol2qm74 2056 6 received receive VBD cord-015021-pol2qm74 2056 7 an an DT cord-015021-pol2qm74 2056 8 intraperitoneal intraperitoneal JJ cord-015021-pol2qm74 2056 9 injection injection NN cord-015021-pol2qm74 2056 10 with with IN cord-015021-pol2qm74 2056 11 zymosan zymosan NNP cord-015021-pol2qm74 2056 12 suspended suspend VBN cord-015021-pol2qm74 2056 13 in in IN cord-015021-pol2qm74 2056 14 paraffin paraffin NN cord-015021-pol2qm74 2056 15 in in IN cord-015021-pol2qm74 2056 16 a a DT cord-015021-pol2qm74 2056 17 dose dose NN cord-015021-pol2qm74 2056 18 of of IN cord-015021-pol2qm74 2056 19 1 1 CD cord-015021-pol2qm74 2056 20 mg mg NNP cord-015021-pol2qm74 2056 21 / / SYM cord-015021-pol2qm74 2056 22 g g NN cord-015021-pol2qm74 2056 23 body body NN cord-015021-pol2qm74 2056 24 weight weight NN cord-015021-pol2qm74 2056 25 . . . cord-015021-pol2qm74 2057 1 Between between IN cord-015021-pol2qm74 2057 2 day day NN cord-015021-pol2qm74 2057 3 0 0 CD cord-015021-pol2qm74 2057 4 and and CC cord-015021-pol2qm74 2057 5 12 12 CD cord-015021-pol2qm74 2057 6 , , , cord-015021-pol2qm74 2057 7 biological biological JJ cord-015021-pol2qm74 2057 8 parameters parameter NNS cord-015021-pol2qm74 2057 9 ( ( -LRB- cord-015021-pol2qm74 2057 10 temperature temperature NN cord-015021-pol2qm74 2057 11 , , , cord-015021-pol2qm74 2057 12 body body NN cord-015021-pol2qm74 2057 13 weight weight NN cord-015021-pol2qm74 2057 14 and and CC cord-015021-pol2qm74 2057 15 clinical clinical JJ cord-015021-pol2qm74 2057 16 condition condition NN cord-015021-pol2qm74 2057 17 ) ) -RRB- cord-015021-pol2qm74 2057 18 were be VBD cord-015021-pol2qm74 2057 19 measured measure VBN cord-015021-pol2qm74 2057 20 daily daily RB cord-015021-pol2qm74 2057 21 and and CC cord-015021-pol2qm74 2057 22 mortality mortality NN cord-015021-pol2qm74 2057 23 was be VBD cord-015021-pol2qm74 2057 24 monitored monitor VBN cord-015021-pol2qm74 2057 25 . . . cord-015021-pol2qm74 2058 1 Clinical clinical JJ cord-015021-pol2qm74 2058 2 condition condition NN cord-015021-pol2qm74 2058 3 was be VBD cord-015021-pol2qm74 2058 4 assessed assess VBN cord-015021-pol2qm74 2058 5 by by IN cord-015021-pol2qm74 2058 6 blindly blindly RB cord-015021-pol2qm74 2058 7 grading grade VBG cord-015021-pol2qm74 2058 8 the the DT cord-015021-pol2qm74 2058 9 degree degree NN cord-015021-pol2qm74 2058 10 of of IN cord-015021-pol2qm74 2058 11 lethargy lethargy NN cord-015021-pol2qm74 2058 12 , , , cord-015021-pol2qm74 2058 13 conjunctivitis conjunctivitis NN cord-015021-pol2qm74 2058 14 , , , cord-015021-pol2qm74 2058 15 diarrhea diarrhea NN cord-015021-pol2qm74 2058 16 , , , cord-015021-pol2qm74 2058 17 and and CC cord-015021-pol2qm74 2058 18 ruffled ruffled JJ cord-015021-pol2qm74 2058 19 fur fur NN cord-015021-pol2qm74 2058 20 of of IN cord-015021-pol2qm74 2058 21 each each DT cord-015021-pol2qm74 2058 22 mouse mouse NN cord-015021-pol2qm74 2058 23 on on IN cord-015021-pol2qm74 2058 24 a a DT cord-015021-pol2qm74 2058 25 two two CD cord-015021-pol2qm74 2058 26 point point NN cord-015021-pol2qm74 2058 27 scale scale NN cord-015021-pol2qm74 2058 28 ( ( -LRB- cord-015021-pol2qm74 2058 29 maximum maximum JJ cord-015021-pol2qm74 2058 30 score=4 score=4 NNS cord-015021-pol2qm74 2058 31 ) ) -RRB- cord-015021-pol2qm74 2058 32 . . . cord-015021-pol2qm74 2059 1 On on IN cord-015021-pol2qm74 2059 2 day day NN cord-015021-pol2qm74 2059 3 12 12 CD cord-015021-pol2qm74 2059 4 all all DT cord-015021-pol2qm74 2059 5 surviving survive VBG cord-015021-pol2qm74 2059 6 mice mouse NNS cord-015021-pol2qm74 2059 7 were be VBD cord-015021-pol2qm74 2059 8 sacrificed sacrifice VBN cord-015021-pol2qm74 2059 9 and and CC cord-015021-pol2qm74 2059 10 relative relative JJ cord-015021-pol2qm74 2059 11 organ organ NN cord-015021-pol2qm74 2059 12 weights weight NNS cord-015021-pol2qm74 2059 13 of of IN cord-015021-pol2qm74 2059 14 lungs lung NNS cord-015021-pol2qm74 2059 15 , , , cord-015021-pol2qm74 2059 16 liver liver NN cord-015021-pol2qm74 2059 17 , , , cord-015021-pol2qm74 2059 18 spleen spleen NN cord-015021-pol2qm74 2059 19 and and CC cord-015021-pol2qm74 2059 20 kidneys kidney NNS cord-015021-pol2qm74 2059 21 ( ( -LRB- cord-015021-pol2qm74 2059 22 relative relative JJ cord-015021-pol2qm74 2059 23 organ organ NN cord-015021-pol2qm74 2059 24 weight= weight= NN cord-015021-pol2qm74 2059 25 ( ( -LRB- cord-015021-pol2qm74 2059 26 organ organ NN cord-015021-pol2qm74 2059 27 weight weight NN cord-015021-pol2qm74 2059 28 / / SYM cord-015021-pol2qm74 2059 29 body body NN cord-015021-pol2qm74 2059 30 weight)x100 weight)x100 NFP cord-015021-pol2qm74 2059 31 ) ) -RRB- cord-015021-pol2qm74 2059 32 wore wear VBD cord-015021-pol2qm74 2059 33 calculated calculate VBN cord-015021-pol2qm74 2059 34 . . . cord-015021-pol2qm74 2060 1 Earlier early JJR cord-015021-pol2qm74 2060 2 experiments experiment NNS cord-015021-pol2qm74 2060 3 with with IN cord-015021-pol2qm74 2060 4 our -PRON- PRP$ cord-015021-pol2qm74 2060 5 model model NN cord-015021-pol2qm74 2060 6 have have VBP cord-015021-pol2qm74 2060 7 shown show VBN cord-015021-pol2qm74 2060 8 a a DT cord-015021-pol2qm74 2060 9 good good JJ cord-015021-pol2qm74 2060 10 correlation correlation NN cord-015021-pol2qm74 2060 11 between between IN cord-015021-pol2qm74 2060 12 histological histological JJ cord-015021-pol2qm74 2060 13 organ organ NN cord-015021-pol2qm74 2060 14 damage damage NN cord-015021-pol2qm74 2060 15 and and CC cord-015021-pol2qm74 2060 16 relative relative JJ cord-015021-pol2qm74 2060 17 organ organ NN cord-015021-pol2qm74 2060 18 weights weight NNS cord-015021-pol2qm74 2060 19 . . . cord-015021-pol2qm74 2061 1 Statistical statistical JJ cord-015021-pol2qm74 2061 2 analysis analysis NN cord-015021-pol2qm74 2061 3 of of IN cord-015021-pol2qm74 2061 4 biological biological JJ cord-015021-pol2qm74 2061 5 parameter parameter NN cord-015021-pol2qm74 2061 6 was be VBD cord-015021-pol2qm74 2061 7 performed perform VBN cord-015021-pol2qm74 2061 8 using use VBG cord-015021-pol2qm74 2061 9 the the DT cord-015021-pol2qm74 2061 10 Koziol Koziol NNP cord-015021-pol2qm74 2061 11 curve curve NN cord-015021-pol2qm74 2061 12 analysis analysis NN cord-015021-pol2qm74 2061 13 . . . cord-015021-pol2qm74 2062 1 Analysis analysis NN cord-015021-pol2qm74 2062 2 was be VBD cord-015021-pol2qm74 2062 3 divided divide VBN cord-015021-pol2qm74 2062 4 in in IN cord-015021-pol2qm74 2062 5 an an DT cord-015021-pol2qm74 2062 6 acute acute JJ cord-015021-pol2qm74 2062 7 phase phase NN cord-015021-pol2qm74 2062 8 ( ( -LRB- cord-015021-pol2qm74 2062 9 day day NN cord-015021-pol2qm74 2062 10 0 0 CD cord-015021-pol2qm74 2062 11 - - SYM cord-015021-pol2qm74 2062 12 4 4 CD cord-015021-pol2qm74 2062 13 ) ) -RRB- cord-015021-pol2qm74 2062 14 and and CC cord-015021-pol2qm74 2062 15 a a DT cord-015021-pol2qm74 2062 16 late late JJ cord-015021-pol2qm74 2062 17 phase phase NN cord-015021-pol2qm74 2062 18 ( ( -LRB- cord-015021-pol2qm74 2062 19 day day NN cord-015021-pol2qm74 2062 20 8 8 CD cord-015021-pol2qm74 2062 21 - - SYM cord-015021-pol2qm74 2062 22 12 12 CD cord-015021-pol2qm74 2062 23 ) ) -RRB- cord-015021-pol2qm74 2062 24 . . . cord-015021-pol2qm74 2063 1 Relative relative JJ cord-015021-pol2qm74 2063 2 organ organ NN cord-015021-pol2qm74 2063 3 weights weight NNS cord-015021-pol2qm74 2063 4 were be VBD cord-015021-pol2qm74 2063 5 analyzed analyze VBN cord-015021-pol2qm74 2063 6 using use VBG cord-015021-pol2qm74 2063 7 Wilcoxon Wilcoxon NNP cord-015021-pol2qm74 2063 8 's 's POS cord-015021-pol2qm74 2063 9 test test NN cord-015021-pol2qm74 2063 10 and and CC cord-015021-pol2qm74 2063 11 mortality mortality NN cord-015021-pol2qm74 2063 12 rate rate NN cord-015021-pol2qm74 2063 13 using use VBG cord-015021-pol2qm74 2063 14 Fischor Fischor NNP cord-015021-pol2qm74 2063 15 's 's POS cord-015021-pol2qm74 2063 16 exact exact JJ cord-015021-pol2qm74 2063 17 test test NN cord-015021-pol2qm74 2063 18 . . . cord-015021-pol2qm74 2064 1 Results result NNS cord-015021-pol2qm74 2064 2 . . . cord-015021-pol2qm74 2065 1 All all DT cord-015021-pol2qm74 2065 2 zymosan zymosan NNP cord-015021-pol2qm74 2065 3 injected inject VBD cord-015021-pol2qm74 2065 4 mice mouse NNS cord-015021-pol2qm74 2066 1 showed show VBD cord-015021-pol2qm74 2066 2 a a DT cord-015021-pol2qm74 2066 3 typical typical JJ cord-015021-pol2qm74 2066 4 triphesic triphesic NN cord-015021-pol2qm74 2066 5 illness illness NN cord-015021-pol2qm74 2066 6 . . . cord-015021-pol2qm74 2067 1 Deterioration deterioration NN cord-015021-pol2qm74 2067 2 of of IN cord-015021-pol2qm74 2067 3 the the DT cord-015021-pol2qm74 2067 4 clinical clinical JJ cord-015021-pol2qm74 2067 5 condition condition NN cord-015021-pol2qm74 2067 6 as as IN cord-015021-pol2qm74 2067 7 indicated indicate VBN cord-015021-pol2qm74 2067 8 by by IN cord-015021-pol2qm74 2067 9 the the DT cord-015021-pol2qm74 2067 10 symptom symptom NN cord-015021-pol2qm74 2067 11 score score NN cord-015021-pol2qm74 2067 12 and and CC cord-015021-pol2qm74 2067 13 the the DT cord-015021-pol2qm74 2067 14 decrease decrease NN cord-015021-pol2qm74 2067 15 in in IN cord-015021-pol2qm74 2067 16 temperature temperature NN cord-015021-pol2qm74 2067 17 and and CC cord-015021-pol2qm74 2067 18 body body NN cord-015021-pol2qm74 2067 19 weight weight NN cord-015021-pol2qm74 2067 20 in in IN cord-015021-pol2qm74 2067 21 the the DT cord-015021-pol2qm74 2067 22 acute acute JJ cord-015021-pol2qm74 2067 23 phase phase NN cord-015021-pol2qm74 2067 24 were be VBD cord-015021-pol2qm74 2067 25 all all DT cord-015021-pol2qm74 2067 26 significantly significantly RB cord-015021-pol2qm74 2067 27 lass lass JJ cord-015021-pol2qm74 2067 28 severe severe JJ cord-015021-pol2qm74 2067 29 in in IN cord-015021-pol2qm74 2067 30 C5 c5 NN cord-015021-pol2qm74 2067 31 deficient deficient JJ cord-015021-pol2qm74 2067 32 mice mouse NNS cord-015021-pol2qm74 2067 33 ( ( -LRB- cord-015021-pol2qm74 2067 34 all all DT cord-015021-pol2qm74 2067 35 p<0.005 p<0.005 JJ cord-015021-pol2qm74 2067 36 ) ) -RRB- cord-015021-pol2qm74 2067 37 . . . cord-015021-pol2qm74 2068 1 In in IN cord-015021-pol2qm74 2068 2 the the DT cord-015021-pol2qm74 2068 3 late late JJ cord-015021-pol2qm74 2068 4 phase phase NN cord-015021-pol2qm74 2068 5 no no DT cord-015021-pol2qm74 2068 6 differences difference NNS cord-015021-pol2qm74 2068 7 could could MD cord-015021-pol2qm74 2068 8 be be VB cord-015021-pol2qm74 2068 9 noticed notice VBN cord-015021-pol2qm74 2068 10 in in IN cord-015021-pol2qm74 2068 11 the the DT cord-015021-pol2qm74 2068 12 courses course NNS cord-015021-pol2qm74 2068 13 of of IN cord-015021-pol2qm74 2068 14 biological biological JJ cord-015021-pol2qm74 2068 15 parameters parameter NNS cord-015021-pol2qm74 2068 16 . . . cord-015021-pol2qm74 2069 1 Overall overall JJ cord-015021-pol2qm74 2069 2 mortality mortality NN cord-015021-pol2qm74 2069 3 was be VBD cord-015021-pol2qm74 2069 4 2/25 2/25 CD cord-015021-pol2qm74 2069 5 ( ( -LRB- cord-015021-pol2qm74 2069 6 8 8 CD cord-015021-pol2qm74 2069 7 % % NN cord-015021-pol2qm74 2069 8 ) ) -RRB- cord-015021-pol2qm74 2069 9 in in IN cord-015021-pol2qm74 2069 10 C5 c5 NN cord-015021-pol2qm74 2069 11 deficient deficient JJ cord-015021-pol2qm74 2069 12 mice mouse NNS cord-015021-pol2qm74 2069 13 and and CC cord-015021-pol2qm74 2069 14 8/25 8/25 CD cord-015021-pol2qm74 2069 15 ( ( -LRB- cord-015021-pol2qm74 2069 16 32 32 CD cord-015021-pol2qm74 2069 17 % % NN cord-015021-pol2qm74 2069 18 ) ) -RRB- cord-015021-pol2qm74 2070 1 Jn Jn NNP cord-015021-pol2qm74 2070 2 C5 C5 NNP cord-015021-pol2qm74 2070 3 sufficient sufficient JJ cord-015021-pol2qm74 2070 4 mice mouse NNS cord-015021-pol2qm74 2070 5 ( ( -LRB- cord-015021-pol2qm74 2070 6 p=0.049 p=0.049 NNP cord-015021-pol2qm74 2070 7 ) ) -RRB- cord-015021-pol2qm74 2070 8 , , , cord-015021-pol2qm74 2070 9 a a DT cord-015021-pol2qm74 2070 10 difference difference NN cord-015021-pol2qm74 2070 11 mainly mainly RB cord-015021-pol2qm74 2070 12 due due IN cord-015021-pol2qm74 2070 13 to to IN cord-015021-pol2qm74 2070 14 a a DT cord-015021-pol2qm74 2070 15 difference difference NN cord-015021-pol2qm74 2070 16 in in IN cord-015021-pol2qm74 2070 17 the the DT cord-015021-pol2qm74 2070 18 acute acute JJ cord-015021-pol2qm74 2070 19 phase phase NN cord-015021-pol2qm74 2070 20 . . . cord-015021-pol2qm74 2071 1 Organ organ NN cord-015021-pol2qm74 2071 2 damage damage NN cord-015021-pol2qm74 2071 3 assessed assess VBN cord-015021-pol2qm74 2071 4 as as IN cord-015021-pol2qm74 2071 5 the the DT cord-015021-pol2qm74 2071 6 relative relative JJ cord-015021-pol2qm74 2071 7 organ organ NN cord-015021-pol2qm74 2071 8 weights weight NNS cord-015021-pol2qm74 2071 9 did do VBD cord-015021-pol2qm74 2071 10 not not RB cord-015021-pol2qm74 2071 11 show show VB cord-015021-pol2qm74 2071 12 any any DT cord-015021-pol2qm74 2071 13 statistical statistical JJ cord-015021-pol2qm74 2071 14 differences difference NNS cord-015021-pol2qm74 2071 15 for for IN cord-015021-pol2qm74 2071 16 any any DT cord-015021-pol2qm74 2071 17 organ organ NN cord-015021-pol2qm74 2071 18 between between IN cord-015021-pol2qm74 2071 19 both both DT cord-015021-pol2qm74 2071 20 strains strain NNS cord-015021-pol2qm74 2071 21 . . . cord-015021-pol2qm74 2072 1 Conclusion conclusion NN cord-015021-pol2qm74 2072 2 . . . cord-015021-pol2qm74 2073 1 Complement complement NN cord-015021-pol2qm74 2073 2 factor factor NN cord-015021-pol2qm74 2073 3 C5 C5 NNP cord-015021-pol2qm74 2073 4 appears appear VBZ cord-015021-pol2qm74 2073 5 to to TO cord-015021-pol2qm74 2073 6 play play VB cord-015021-pol2qm74 2073 7 an an DT cord-015021-pol2qm74 2073 8 important important JJ cord-015021-pol2qm74 2073 9 role role NN cord-015021-pol2qm74 2073 10 in in IN cord-015021-pol2qm74 2073 11 the the DT cord-015021-pol2qm74 2073 12 acute acute JJ cord-015021-pol2qm74 2073 13 hyperdynamic hyperdynamic JJ cord-015021-pol2qm74 2073 14 septic septic JJ cord-015021-pol2qm74 2073 15 response response NN cord-015021-pol2qm74 2073 16 in in IN cord-015021-pol2qm74 2073 17 this this DT cord-015021-pol2qm74 2073 18 model model NN cord-015021-pol2qm74 2073 19 but but CC cord-015021-pol2qm74 2073 20 deficiency deficiency NN cord-015021-pol2qm74 2073 21 of of IN cord-015021-pol2qm74 2073 22 C5 C5 NNP cord-015021-pol2qm74 2073 23 could could MD cord-015021-pol2qm74 2073 24 not not RB cord-015021-pol2qm74 2073 25 prevent prevent VB cord-015021-pol2qm74 2073 26 organ organ NN cord-015021-pol2qm74 2073 27 damage damage NN cord-015021-pol2qm74 2073 28 in in IN cord-015021-pol2qm74 2073 29 the the DT cord-015021-pol2qm74 2073 30 late late JJ cord-015021-pol2qm74 2073 31 MOF MOF NNP cord-015021-pol2qm74 2073 32 phase phase NN cord-015021-pol2qm74 2073 33 . . . cord-015021-pol2qm74 2074 1 This this DT cord-015021-pol2qm74 2074 2 suggests suggest VBZ cord-015021-pol2qm74 2074 3 that that IN cord-015021-pol2qm74 2074 4 other other JJ cord-015021-pol2qm74 2074 5 factors factor NNS cord-015021-pol2qm74 2074 6 could could MD cord-015021-pol2qm74 2074 7 be be VB cord-015021-pol2qm74 2074 8 more more RBR cord-015021-pol2qm74 2074 9 important important JJ cord-015021-pol2qm74 2074 10 in in IN cord-015021-pol2qm74 2074 11 the the DT cord-015021-pol2qm74 2074 12 development development NN cord-015021-pol2qm74 2074 13 of of IN cord-015021-pol2qm74 2074 14 the the DT cord-015021-pol2qm74 2074 15 inflammatory inflammatory JJ cord-015021-pol2qm74 2074 16 response response NN cord-015021-pol2qm74 2074 17 leading lead VBG cord-015021-pol2qm74 2074 18 to to IN cord-015021-pol2qm74 2074 19 MOF MOF NNP cord-015021-pol2qm74 2074 20 . . . cord-015021-pol2qm74 2075 1 Proinflammatory proinflammatory NN cord-015021-pol2qm74 2075 2 cytokines cytokine NNS cord-015021-pol2qm74 2075 3 are be VBP cord-015021-pol2qm74 2075 4 thought think VBN cord-015021-pol2qm74 2075 5 to to TO cord-015021-pol2qm74 2075 6 play play VB cord-015021-pol2qm74 2075 7 a a DT cord-015021-pol2qm74 2075 8 critical critical JJ cord-015021-pol2qm74 2075 9 role role NN cord-015021-pol2qm74 2075 10 in in IN cord-015021-pol2qm74 2075 11 the the DT cord-015021-pol2qm74 2075 12 pathophysiology pathophysiology NN cord-015021-pol2qm74 2075 13 of of IN cord-015021-pol2qm74 2075 14 Multiple Multiple NNP cord-015021-pol2qm74 2075 15 Organ Organ NNP cord-015021-pol2qm74 2075 16 Failure Failure NNP cord-015021-pol2qm74 2075 17 ( ( -LRB- cord-015021-pol2qm74 2075 18 MOF MOF NNP cord-015021-pol2qm74 2075 19 ) ) -RRB- cord-015021-pol2qm74 2075 20 . . . cord-015021-pol2qm74 2076 1 In in IN cord-015021-pol2qm74 2076 2 mice mouse NNS cord-015021-pol2qm74 2076 3 , , , cord-015021-pol2qm74 2076 4 Zymosan Zymosan NNP cord-015021-pol2qm74 2076 5 - - HYPH cord-015021-pol2qm74 2076 6 lnduced lnduce VBN cord-015021-pol2qm74 2076 7 Generalized Generalized NNP cord-015021-pol2qm74 2076 8 Inflammation Inflammation NNP cord-015021-pol2qm74 2076 9 ( ( -LRB- cord-015021-pol2qm74 2076 10 ZtGI ZtGI NNP cord-015021-pol2qm74 2076 11 ) ) -RRB- cord-015021-pol2qm74 2076 12 leads lead VBZ cord-015021-pol2qm74 2076 13 to to IN cord-015021-pol2qm74 2076 14 MOF MOF NNP cord-015021-pol2qm74 2076 15 . . . cord-015021-pol2qm74 2077 1 Therefore therefore RB cord-015021-pol2qm74 2077 2 we -PRON- PRP cord-015021-pol2qm74 2077 3 performed perform VBD cord-015021-pol2qm74 2077 4 a a DT cord-015021-pol2qm74 2077 5 sequential sequential JJ cord-015021-pol2qm74 2077 6 study study NN cord-015021-pol2qm74 2077 7 into into IN cord-015021-pol2qm74 2077 8 plasma plasma NN cord-015021-pol2qm74 2077 9 levels level NNS cord-015021-pol2qm74 2077 10 of of IN cord-015021-pol2qm74 2077 11 , , , cord-015021-pol2qm74 2077 12 and and CC cord-015021-pol2qm74 2077 13 macrophage macrophage NN cord-015021-pol2qm74 2077 14 production production NN cord-015021-pol2qm74 2077 15 capacity capacity NN cord-015021-pol2qm74 2077 16 for for IN cord-015021-pol2qm74 2077 17 , , , cord-015021-pol2qm74 2077 18 four four CD cord-015021-pol2qm74 2077 19 cytokines cytokine NNS cord-015021-pol2qm74 2077 20 during during IN cord-015021-pol2qm74 2077 21 the the DT cord-015021-pol2qm74 2077 22 development development NN cord-015021-pol2qm74 2077 23 of of IN cord-015021-pol2qm74 2077 24 MOF MOF NNP cord-015021-pol2qm74 2077 25 in in IN cord-015021-pol2qm74 2077 26 the the DT cord-015021-pol2qm74 2077 27 ZIGI ZIGI NNP cord-015021-pol2qm74 2077 28 model model NN cord-015021-pol2qm74 2077 29 . . . cord-015021-pol2qm74 2078 1 Male male JJ cord-015021-pol2qm74 2078 2 young young JJ cord-015021-pol2qm74 2078 3 - - HYPH cord-015021-pol2qm74 2078 4 adult adult NN cord-015021-pol2qm74 2078 5 C57BL/6 C57BL/6 NNP cord-015021-pol2qm74 2078 6 mice mouse NNS cord-015021-pol2qm74 2078 7 received receive VBD cord-015021-pol2qm74 2078 8 zymosan zymosan NNP cord-015021-pol2qm74 2078 9 ( ( -LRB- cord-015021-pol2qm74 2078 10 1 1 CD cord-015021-pol2qm74 2078 11 mg mg NNP cord-015021-pol2qm74 2078 12 / / SYM cord-015021-pol2qm74 2078 13 g g NN cord-015021-pol2qm74 2078 14 body body NN cord-015021-pol2qm74 2078 15 weight weight NN cord-015021-pol2qm74 2078 16 ) ) -RRB- cord-015021-pol2qm74 2078 17 intraperitoneally intraperitoneally RB cord-015021-pol2qm74 2078 18 . . . cord-015021-pol2qm74 2079 1 Groups group NNS cord-015021-pol2qm74 2079 2 of of IN cord-015021-pol2qm74 2079 3 14 14 CD cord-015021-pol2qm74 2079 4 animals animal NNS cord-015021-pol2qm74 2079 5 were be VBD cord-015021-pol2qm74 2079 6 killed kill VBN cord-015021-pol2qm74 2079 7 after after IN cord-015021-pol2qm74 2079 8 3 3 CD cord-015021-pol2qm74 2079 9 , , , cord-015021-pol2qm74 2079 10 6 6 CD cord-015021-pol2qm74 2079 11 , , , cord-015021-pol2qm74 2079 12 8 8 CD cord-015021-pol2qm74 2079 13 , , , cord-015021-pol2qm74 2079 14 18 18 CD cord-015021-pol2qm74 2079 15 and and CC cord-015021-pol2qm74 2079 16 24h 24h NNS cord-015021-pol2qm74 2079 17 and and CC cord-015021-pol2qm74 2079 18 subsequently subsequently RB cord-015021-pol2qm74 2079 19 at at IN cord-015021-pol2qm74 2079 20 each each DT cord-015021-pol2qm74 2079 21 day day NN cord-015021-pol2qm74 2079 22 until until IN cord-015021-pol2qm74 2079 23 day day NN cord-015021-pol2qm74 2079 24 12 12 CD cord-015021-pol2qm74 2079 25 . . . cord-015021-pol2qm74 2080 1 Plasma plasma NN cord-015021-pol2qm74 2080 2 was be VBD cord-015021-pol2qm74 2080 3 collected collect VBN cord-015021-pol2qm74 2080 4 and and CC cord-015021-pol2qm74 2080 5 peritoneal peritoneal JJ cord-015021-pol2qm74 2080 6 macrophages macrophage NNS cord-015021-pol2qm74 2080 7 were be VBD cord-015021-pol2qm74 2080 8 isolated isolate VBN cord-015021-pol2qm74 2080 9 and and CC cord-015021-pol2qm74 2080 10 cultured cultured JJ cord-015021-pol2qm74 2080 11 overnight overnight RB cord-015021-pol2qm74 2080 12 with with IN cord-015021-pol2qm74 2080 13 or or CC cord-015021-pol2qm74 2080 14 without without IN cord-015021-pol2qm74 2080 15 lipopolysaccharide lipopolysaccharide NN cord-015021-pol2qm74 2080 16 ( ( -LRB- cord-015021-pol2qm74 2080 17 LPS LPS NNP cord-015021-pol2qm74 2080 18 ) ) -RRB- cord-015021-pol2qm74 2080 19 . . . cord-015021-pol2qm74 2081 1 Interleukin interleukin NN cord-015021-pol2qm74 2081 2 1-ct 1-ct CD cord-015021-pol2qm74 2081 3 , , , cord-015021-pol2qm74 2081 4 and and CC cord-015021-pol2qm74 2081 5 -6 -6 NNP cord-015021-pol2qm74 2082 1 ( ( -LRB- cord-015021-pol2qm74 2082 2 IL IL NNP cord-015021-pol2qm74 2082 3 - - HYPH cord-015021-pol2qm74 2082 4 lc~,~ lc~,~ NNP cord-015021-pol2qm74 2082 5 , , , cord-015021-pol2qm74 2082 6 ) ) -RRB- cord-015021-pol2qm74 2082 7 , , , cord-015021-pol2qm74 2082 8 and and CC cord-015021-pol2qm74 2082 9 tumour tumour NN cord-015021-pol2qm74 2082 10 necrosis necrosis NN cord-015021-pol2qm74 2082 11 factor factor NN cord-015021-pol2qm74 2082 12 - - HYPH cord-015021-pol2qm74 2082 13 o~ o~ XX cord-015021-pol2qm74 2083 1 ( ( -LRB- cord-015021-pol2qm74 2083 2 TNF TNF NNP cord-015021-pol2qm74 2083 3 - - HYPH cord-015021-pol2qm74 2083 4 c c NNP cord-015021-pol2qm74 2083 5 0 0 CD cord-015021-pol2qm74 2083 6 were be VBD cord-015021-pol2qm74 2083 7 measured measure VBN cord-015021-pol2qm74 2083 8 in in IN cord-015021-pol2qm74 2083 9 plasma plasma NN cord-015021-pol2qm74 2083 10 and and CC cord-015021-pol2qm74 2083 11 culture culture NN cord-015021-pol2qm74 2083 12 fluid fluid NN cord-015021-pol2qm74 2083 13 by by IN cord-015021-pol2qm74 2083 14 means mean NNS cord-015021-pol2qm74 2083 15 of of IN cord-015021-pol2qm74 2083 16 a a DT cord-015021-pol2qm74 2083 17 RIA RIA NNP cord-015021-pol2qm74 2083 18 ( ( -LRB- cord-015021-pol2qm74 2083 19 detection detection NN cord-015021-pol2qm74 2083 20 limit limit NN cord-015021-pol2qm74 2083 21 0.1 0.1 CD cord-015021-pol2qm74 2083 22 ng ng NN cord-015021-pol2qm74 2083 23 / / SYM cord-015021-pol2qm74 2083 24 ml ml NN cord-015021-pol2qm74 2083 25 ) ) -RRB- cord-015021-pol2qm74 2083 26 . . . cord-015021-pol2qm74 2084 1 Interleukin-6 Interleukin-6 NNP cord-015021-pol2qm74 2084 2 ( ( -LRB- cord-015021-pol2qm74 2084 3 IL~ IL~ NNP cord-015021-pol2qm74 2084 4 ) ) -RRB- cord-015021-pol2qm74 2084 5 levels level NNS cord-015021-pol2qm74 2084 6 were be VBD cord-015021-pol2qm74 2084 7 assayed assay VBN cord-015021-pol2qm74 2084 8 using use VBG cord-015021-pol2qm74 2084 9 the the DT cord-015021-pol2qm74 2084 10 B9 B9 NNP cord-015021-pol2qm74 2084 11 hybddoma hybddoma NNP cord-015021-pol2qm74 2084 12 cell cell NN cord-015021-pol2qm74 2084 13 proliferation proliferation NN cord-015021-pol2qm74 2084 14 assay assay NN cord-015021-pol2qm74 2084 15 . . . cord-015021-pol2qm74 2085 1 Zymosan Zymosan NNP cord-015021-pol2qm74 2085 2 induces induce VBZ cord-015021-pol2qm74 2085 3 a a DT cord-015021-pol2qm74 2085 4 three three CD cord-015021-pol2qm74 2085 5 - - HYPH cord-015021-pol2qm74 2085 6 phase phase NN cord-015021-pol2qm74 2085 7 disease disease NN cord-015021-pol2qm74 2085 8 in in IN cord-015021-pol2qm74 2085 9 mice mouse NNS cord-015021-pol2qm74 2085 10 . . . cord-015021-pol2qm74 2086 1 After after IN cord-015021-pol2qm74 2086 2 an an DT cord-015021-pol2qm74 2086 3 acute acute JJ cord-015021-pol2qm74 2086 4 phase phase NN cord-015021-pol2qm74 2086 5 the the DT cord-015021-pol2qm74 2086 6 animals animal NNS cord-015021-pol2qm74 2086 7 recover recover VBP cord-015021-pol2qm74 2086 8 . . . cord-015021-pol2qm74 2087 1 Around around IN cord-015021-pol2qm74 2087 2 day day NN cord-015021-pol2qm74 2087 3 7 7 CD cord-015021-pol2qm74 2087 4 , , , cord-015021-pol2qm74 2087 5 they -PRON- PRP cord-015021-pol2qm74 2087 6 start start VBP cord-015021-pol2qm74 2087 7 to to TO cord-015021-pol2qm74 2087 8 develop develop VB cord-015021-pol2qm74 2087 9 clinical clinical JJ cord-015021-pol2qm74 2087 10 signs sign NNS cord-015021-pol2qm74 2087 11 which which WDT cord-015021-pol2qm74 2087 12 resemble resemble VBP cord-015021-pol2qm74 2087 13 MOF MOF NNP cord-015021-pol2qm74 2087 14 . . . cord-015021-pol2qm74 2088 1 Plasma plasma NN cord-015021-pol2qm74 2088 2 TNF-~ TNF-~ NNP cord-015021-pol2qm74 2088 3 peaked peak VBD cord-015021-pol2qm74 2088 4 within within IN cord-015021-pol2qm74 2088 5 3h 3h CD cord-015021-pol2qm74 2088 6 after after IN cord-015021-pol2qm74 2088 7 zymosan zymosan NNP cord-015021-pol2qm74 2088 8 injection injection NNP cord-015021-pol2qm74 2088 9 and and CC cord-015021-pol2qm74 2088 10 disappeared disappear VBD cord-015021-pol2qm74 2088 11 within within IN cord-015021-pol2qm74 2088 12 8h 8h CD cord-015021-pol2qm74 2088 13 . . . cord-015021-pol2qm74 2089 1 From from IN cord-015021-pol2qm74 2089 2 day day NN cord-015021-pol2qm74 2089 3 8 8 CD cord-015021-pol2qm74 2089 4 onwards onwards RB cord-015021-pol2qm74 2089 5 , , , cord-015021-pol2qm74 2089 6 TNF TNF NNP cord-015021-pol2qm74 2089 7 levels level NNS cord-015021-pol2qm74 2089 8 started start VBD cord-015021-pol2qm74 2089 9 to to TO cord-015021-pol2qm74 2089 10 rise rise VB cord-015021-pol2qm74 2089 11 again again RB cord-015021-pol2qm74 2089 12 . . . cord-015021-pol2qm74 2090 1 Plasma Plasma NNP cord-015021-pol2qm74 2090 2 IL-6 IL-6 NNP cord-015021-pol2qm74 2090 3 behaved behave VBD cord-015021-pol2qm74 2090 4 almost almost RB cord-015021-pol2qm74 2090 5 similarly similarly RB cord-015021-pol2qm74 2090 6 in in IN cord-015021-pol2qm74 2090 7 the the DT cord-015021-pol2qm74 2090 8 acute acute JJ cord-015021-pol2qm74 2090 9 phase phase NN cord-015021-pol2qm74 2090 10 , , , cord-015021-pol2qm74 2090 11 but but CC cord-015021-pol2qm74 2090 12 in in IN cord-015021-pol2qm74 2090 13 the the DT cord-015021-pol2qm74 2090 14 MOF MOF NNP cord-015021-pol2qm74 2090 15 phase phase NN cord-015021-pol2qm74 2090 16 plasma plasma NN cord-015021-pol2qm74 2090 17 IL-6 IL-6 NNP cord-015021-pol2qm74 2090 18 remained remain VBD cord-015021-pol2qm74 2090 19 low low JJ cord-015021-pol2qm74 2090 20 . . . cord-015021-pol2qm74 2091 1 No no DT cord-015021-pol2qm74 2091 2 circulating circulate VBG cord-015021-pol2qm74 2091 3 IL-16 IL-16 NNP cord-015021-pol2qm74 2091 4 could could MD cord-015021-pol2qm74 2091 5 be be VB cord-015021-pol2qm74 2091 6 detected detect VBN cord-015021-pol2qm74 2091 7 at at IN cord-015021-pol2qm74 2091 8 any any DT cord-015021-pol2qm74 2091 9 time time NN cord-015021-pol2qm74 2091 10 point point NN cord-015021-pol2qm74 2091 11 . . . cord-015021-pol2qm74 2092 1 Macrophage macrophage NN cord-015021-pol2qm74 2092 2 LPS LPS NNP cord-015021-pol2qm74 2092 3 - - HYPH cord-015021-pol2qm74 2092 4 stimulated stimulate VBN cord-015021-pol2qm74 2092 5 production production NN cord-015021-pol2qm74 2092 6 of of IN cord-015021-pol2qm74 2092 7 IL IL NNP cord-015021-pol2qm74 2092 8 - - HYPH cord-015021-pol2qm74 2092 9 lcq lcq NNP cord-015021-pol2qm74 2092 10 IL-11~ IL-11~ NNP cord-015021-pol2qm74 2092 11 and and CC cord-015021-pol2qm74 2092 12 TNF TNF NNP cord-015021-pol2qm74 2092 13 -- -- : cord-015021-pol2qm74 2092 14 c~ c~ NNP cord-015021-pol2qm74 2092 15 was be VBD cord-015021-pol2qm74 2092 16 suppressed suppress VBN cord-015021-pol2qm74 2092 17 immediately immediately RB cord-015021-pol2qm74 2092 18 after after IN cord-015021-pol2qm74 2092 19 zymosan zymosan NNP cord-015021-pol2qm74 2092 20 injection injection NN cord-015021-pol2qm74 2092 21 . . . cord-015021-pol2qm74 2093 1 Production production NN cord-015021-pol2qm74 2093 2 of of IN cord-015021-pol2qm74 2093 3 IL-16 IL-16 NNP cord-015021-pol2qm74 2093 4 and and CC cord-015021-pol2qm74 2093 5 TNF-~ TNF-~ NNP cord-015021-pol2qm74 2093 6 was be VBD cord-015021-pol2qm74 2093 7 normalized normalize VBN cord-015021-pol2qm74 2093 8 within within IN cord-015021-pol2qm74 2093 9 6h 6h CD cord-015021-pol2qm74 2093 10 , , , cord-015021-pol2qm74 2093 11 while while IN cord-015021-pol2qm74 2093 12 production production NN cord-015021-pol2qm74 2093 13 of of IN cord-015021-pol2qm74 2093 14 IL IL NNP cord-015021-pol2qm74 2093 15 - - HYPH cord-015021-pol2qm74 2093 16 lc~ lc~ NNP cord-015021-pol2qm74 2093 17 remained remain VBD cord-015021-pol2qm74 2093 18 lower low JJR cord-015021-pol2qm74 2093 19 than than IN cord-015021-pol2qm74 2093 20 that that DT cord-015021-pol2qm74 2093 21 in in IN cord-015021-pol2qm74 2093 22 macrophages macrophage NNS cord-015021-pol2qm74 2093 23 from from IN cord-015021-pol2qm74 2093 24 untreated untreated JJ cord-015021-pol2qm74 2093 25 control control NN cord-015021-pol2qm74 2093 26 mice mouse NNS cord-015021-pol2qm74 2093 27 . . . cord-015021-pol2qm74 2094 1 Only only RB cord-015021-pol2qm74 2094 2 at at IN cord-015021-pol2qm74 2094 3 day day NN cord-015021-pol2qm74 2094 4 6 6 CD cord-015021-pol2qm74 2094 5 did do VBD cord-015021-pol2qm74 2094 6 production production NN cord-015021-pol2qm74 2094 7 of of IN cord-015021-pol2qm74 2094 8 IL IL NNP cord-015021-pol2qm74 2094 9 - - HYPH cord-015021-pol2qm74 2094 10 I~ I~ NNP cord-015021-pol2qm74 2094 11 reach reach VB cord-015021-pol2qm74 2094 12 control control NN cord-015021-pol2qm74 2094 13 values value NNS cord-015021-pol2qm74 2094 14 . . . cord-015021-pol2qm74 2095 1 IL-16 IL-16 NNP cord-015021-pol2qm74 2095 2 production production NN cord-015021-pol2qm74 2095 3 was be VBD cord-015021-pol2qm74 2095 4 higher high JJR cord-015021-pol2qm74 2095 5 than than IN cord-015021-pol2qm74 2095 6 control control NN cord-015021-pol2qm74 2095 7 values value NNS cord-015021-pol2qm74 2095 8 from from IN cord-015021-pol2qm74 2095 9 day day NN cord-015021-pol2qm74 2095 10 3 3 CD cord-015021-pol2qm74 2095 11 onwards onwards RB cord-015021-pol2qm74 2095 12 . . . cord-015021-pol2qm74 2096 1 IL6 il6 NN cord-015021-pol2qm74 2096 2 production production NN cord-015021-pol2qm74 2096 3 was be VBD cord-015021-pol2qm74 2096 4 similar similar JJ cord-015021-pol2qm74 2096 5 to to IN cord-015021-pol2qm74 2096 6 that that DT cord-015021-pol2qm74 2096 7 of of IN cord-015021-pol2qm74 2096 8 ILI ILI NNP cord-015021-pol2qm74 2096 9 - - HYPH cord-015021-pol2qm74 2096 10 IL IL NNP cord-015021-pol2qm74 2097 1 The the DT cord-015021-pol2qm74 2097 2 production production NN cord-015021-pol2qm74 2097 3 of of IN cord-015021-pol2qm74 2097 4 TNF TNF NNP cord-015021-pol2qm74 2097 5 - - HYPH cord-015021-pol2qm74 2097 6 ct ct NNP cord-015021-pol2qm74 2097 7 was be VBD cord-015021-pol2qm74 2097 8 strongly strongly RB cord-015021-pol2qm74 2097 9 elevated elevate VBN cord-015021-pol2qm74 2097 10 between between IN cord-015021-pol2qm74 2097 11 days day NNS cord-015021-pol2qm74 2097 12 1 1 CD cord-015021-pol2qm74 2097 13 and and CC cord-015021-pol2qm74 2097 14 6 6 CD cord-015021-pol2qm74 2097 15 and and CC cord-015021-pol2qm74 2097 16 again again RB cord-015021-pol2qm74 2097 17 during during IN cord-015021-pol2qm74 2097 18 days day NNS cord-015021-pol2qm74 2097 19 10 10 CD cord-015021-pol2qm74 2097 20 to to TO cord-015021-pol2qm74 2097 21 12 12 CD cord-015021-pol2qm74 2097 22 . . . cord-015021-pol2qm74 2098 1 The the DT cord-015021-pol2qm74 2098 2 development development NN cord-015021-pol2qm74 2098 3 of of IN cord-015021-pol2qm74 2098 4 MOF MOF NNP cord-015021-pol2qm74 2098 5 - - HYPH cord-015021-pol2qm74 2098 6 like like JJ cord-015021-pol2qm74 2098 7 symptoms symptom NNS cord-015021-pol2qm74 2098 8 during during IN cord-015021-pol2qm74 2098 9 ZlGI ZlGI NNP cord-015021-pol2qm74 2098 10 in in IN cord-015021-pol2qm74 2098 11 mice mouse NNS cord-015021-pol2qm74 2098 12 is be VBZ cord-015021-pol2qm74 2098 13 accompanied accompany VBN cord-015021-pol2qm74 2098 14 by by IN cord-015021-pol2qm74 2098 15 increased increase VBN cord-015021-pol2qm74 2098 16 plasma plasma NN cord-015021-pol2qm74 2098 17 levels level NNS cord-015021-pol2qm74 2098 18 of of IN cord-015021-pol2qm74 2098 19 TNF TNF NNP cord-015021-pol2qm74 2098 20 - - HYPH cord-015021-pol2qm74 2098 21 ct ct NNP cord-015021-pol2qm74 2098 22 without without IN cord-015021-pol2qm74 2098 23 enhanced enhance VBN cord-015021-pol2qm74 2098 24 IL-16 IL-16 NNP cord-015021-pol2qm74 2098 25 or or CC cord-015021-pol2qm74 2098 26 IL-6 IL-6 NNP cord-015021-pol2qm74 2098 27 . . . cord-015021-pol2qm74 2099 1 Also also RB cord-015021-pol2qm74 2099 2 , , , cord-015021-pol2qm74 2099 3 the the DT cord-015021-pol2qm74 2099 4 ability ability NN cord-015021-pol2qm74 2099 5 of of IN cord-015021-pol2qm74 2099 6 macrophages macrophage NNS cord-015021-pol2qm74 2099 7 to to TO cord-015021-pol2qm74 2099 8 produce produce VB cord-015021-pol2qm74 2099 9 excessive excessive JJ cord-015021-pol2qm74 2099 10 amounts amount NNS cord-015021-pol2qm74 2099 11 of of IN cord-015021-pol2qm74 2099 12 IL-16 IL-16 NNP cord-015021-pol2qm74 2099 13 and and CC cord-015021-pol2qm74 2099 14 TNF--~ TNF--~ NNP cord-015021-pol2qm74 2099 15 , , , cord-015021-pol2qm74 2099 16 as as RB cord-015021-pol2qm74 2099 17 well well RB cord-015021-pol2qm74 2099 18 as as IN cord-015021-pol2qm74 2099 19 the the DT cord-015021-pol2qm74 2099 20 suppressed suppress VBN cord-015021-pol2qm74 2099 21 capacity capacity NN cord-015021-pol2qm74 2099 22 to to TO cord-015021-pol2qm74 2099 23 produce produce VB cord-015021-pol2qm74 2099 24 IL IL NNP cord-015021-pol2qm74 2099 25 - - HYPH cord-015021-pol2qm74 2099 26 lcq lcq NN cord-015021-pol2qm74 2099 27 could could MD cord-015021-pol2qm74 2099 28 be be VB cord-015021-pol2qm74 2099 29 important important JJ cord-015021-pol2qm74 2099 30 mechanisms mechanism NNS cord-015021-pol2qm74 2099 31 in in IN cord-015021-pol2qm74 2099 32 the the DT cord-015021-pol2qm74 2099 33 pathophysiology pathophysiology NN cord-015021-pol2qm74 2099 34 of of IN cord-015021-pol2qm74 2099 35 MOF MOF NNP cord-015021-pol2qm74 2099 36 . . . cord-015021-pol2qm74 2100 1 When when WRB cord-015021-pol2qm74 2100 2 conjugated conjugate VBN cord-015021-pol2qm74 2100 3 to to IN cord-015021-pol2qm74 2100 4 an an DT cord-015021-pol2qm74 2100 5 asialoglycoprotein asialoglycoprotein NN cord-015021-pol2qm74 2100 6 , , , cord-015021-pol2qm74 2100 7 DNA dna NN cord-015021-pol2qm74 2100 8 and and CC cord-015021-pol2qm74 2100 9 oligonucleotides oligonucleotide NNS cord-015021-pol2qm74 2100 10 are be VBP cord-015021-pol2qm74 2100 11 specifically specifically RB cord-015021-pol2qm74 2100 12 taken take VBN cord-015021-pol2qm74 2100 13 up up RP cord-015021-pol2qm74 2100 14 by by IN cord-015021-pol2qm74 2100 15 the the DT cord-015021-pol2qm74 2100 16 hepatocytes hepatocyte NNS cord-015021-pol2qm74 2100 17 via via IN cord-015021-pol2qm74 2100 18 the the DT cord-015021-pol2qm74 2100 19 asialoglyccprotein asialoglyccprotein NNP cord-015021-pol2qm74 2100 20 receptor receptor NN cord-015021-pol2qm74 2100 21 which which WDT cord-015021-pol2qm74 2100 22 is be VBZ cord-015021-pol2qm74 2100 23 unique unique JJ cord-015021-pol2qm74 2100 24 to to IN cord-015021-pol2qm74 2100 25 the the DT cord-015021-pol2qm74 2100 26 liver liver NN cord-015021-pol2qm74 2100 27 . . . cord-015021-pol2qm74 2101 1 Human human JJ cord-015021-pol2qm74 2101 2 asialoglycoprotein asialoglycoprotein NNP cord-015021-pol2qm74 2101 3 ( ( -LRB- cord-015021-pol2qm74 2101 4 ~1-acid ~1-acid NNP cord-015021-pol2qm74 2101 5 , , , cord-015021-pol2qm74 2101 6 ASGP ASGP NNP cord-015021-pol2qm74 2101 7 ) ) -RRB- cord-015021-pol2qm74 2101 8 was be VBD cord-015021-pol2qm74 2101 9 derivatized derivatize VBN cord-015021-pol2qm74 2101 10 with with IN cord-015021-pol2qm74 2101 11 low low JJ cord-015021-pol2qm74 2101 12 molecular molecular JJ cord-015021-pol2qm74 2101 13 weight weight NN cord-015021-pol2qm74 2101 14 poly(L)lysine(PLL poly(L)lysine(PLL NNP cord-015021-pol2qm74 2101 15 ) ) -RRB- cord-015021-pol2qm74 2101 16 and and CC cord-015021-pol2qm74 2101 17 complexed complexe VBN cord-015021-pol2qm74 2101 18 with with IN cord-015021-pol2qm74 2101 19 5 5 CD cord-015021-pol2qm74 2101 20 antisense antisense NN cord-015021-pol2qm74 2101 21 DNA DNA NNP cord-015021-pol2qm74 2101 22 's 's POS cord-015021-pol2qm74 2101 23 ( ( -LRB- cord-015021-pol2qm74 2101 24 AS AS NNP cord-015021-pol2qm74 2101 25 ) ) -RRB- cord-015021-pol2qm74 2101 26 complementary complementary JJ cord-015021-pol2qm74 2101 27 to to IN cord-015021-pol2qm74 2101 28 the the DT cord-015021-pol2qm74 2101 29 5 5 CD cord-015021-pol2qm74 2101 30 ' ' POS cord-015021-pol2qm74 2101 31 region region NN cord-015021-pol2qm74 2101 32 of of IN cord-015021-pol2qm74 2101 33 the the DT cord-015021-pol2qm74 2101 34 IL-6 IL-6 NNP cord-015021-pol2qm74 2101 35 gpl30 gpl30 NNP cord-015021-pol2qm74 2101 36 receptor receptor NN cord-015021-pol2qm74 2101 37 . . . cord-015021-pol2qm74 2102 1 The the DT cord-015021-pol2qm74 2102 2 antisense antisense NN cord-015021-pol2qm74 2102 3 were be VBD cord-015021-pol2qm74 2102 4 5'-AGTTTAGGGATGAGG-3 5'-agtttagggatgagg-3 CD cord-015021-pol2qm74 2102 5 ' ' '' cord-015021-pol2qm74 2102 6 ( ( -LRB- cord-015021-pol2qm74 2102 7 ASl ASl NNS cord-015021-pol2qm74 2102 8 ) ) -RRB- cord-015021-pol2qm74 2102 9 , , , cord-015021-pol2qm74 2102 10 5'-ATCTTCATCTTCTGAAT-3 5'-atcttcatcttctgaat-3 CD cord-015021-pol2qm74 2102 11 ' ' '' cord-015021-pol2qm74 2102 12 ( ( -LRB- cord-015021-pol2qm74 2102 13 AS2 AS2 NNP cord-015021-pol2qm74 2102 14 ) ) -RRB- cord-015021-pol2qm74 2102 15 , , , cord-015021-pol2qm74 2102 16 5'-AAGTGAATGATTAAAACACT-3 5'-aagtgaatgattaaaacact-3 CD cord-015021-pol2qm74 2102 17 ' ' '' cord-015021-pol2qm74 2102 18 ( ( -LRB- cord-015021-pol2qm74 2102 19 AS3 AS3 NNP cord-015021-pol2qm74 2102 20 ) ) -RRB- cord-015021-pol2qm74 2102 21 , , , cord-015021-pol2qm74 2102 22 5'-AAACCTTTATAGGCG-3 5'-AAACCTTTATAGGCG-3 NNP cord-015021-pol2qm74 2102 23 ' ' '' cord-015021-pol2qm74 2102 24 ( ( -LRB- cord-015021-pol2qm74 2102 25 AS4 AS4 NNP cord-015021-pol2qm74 2102 26 ) ) -RRB- cord-015021-pol2qm74 2102 27 , , , cord-015021-pol2qm74 2102 28 and and CC cord-015021-pol2qm74 2102 29 5'-CGTTCTACAACTGCAACGT-3 5'-cgttctacaactgcaacgt-3 CD cord-015021-pol2qm74 2102 30 ' ' '' cord-015021-pol2qm74 2102 31 ( ( -LRB- cord-015021-pol2qm74 2102 32 AS5 AS5 NNP cord-015021-pol2qm74 2102 33 ) ) -RRB- cord-015021-pol2qm74 2102 34 . . . cord-015021-pol2qm74 2103 1 Using use VBG cord-015021-pol2qm74 2103 2 HepG2 HepG2 NNP cord-015021-pol2qm74 2103 3 , , , cord-015021-pol2qm74 2103 4 the the DT cord-015021-pol2qm74 2103 5 biological biological JJ cord-015021-pol2qm74 2103 6 effects effect NNS cord-015021-pol2qm74 2103 7 of of IN cord-015021-pol2qm74 2103 8 these these DT cord-015021-pol2qm74 2103 9 antisense antisense NN cord-015021-pol2qm74 2103 10 complexes complex NNS cord-015021-pol2qm74 2103 11 on on IN cord-015021-pol2qm74 2103 12 the the DT cord-015021-pol2qm74 2103 13 high high JJ cord-015021-pol2qm74 2103 14 affinity affinity NN cord-015021-pol2qm74 2103 15 IL-6 IL-6 NNP cord-015021-pol2qm74 2103 16 receptor receptor NN cord-015021-pol2qm74 2103 17 were be VBD cord-015021-pol2qm74 2103 18 evaluated evaluate VBN cord-015021-pol2qm74 2103 19 by by IN cord-015021-pol2qm74 2103 20 Scatchard Scatchard NNP cord-015021-pol2qm74 2103 21 analysis analysis NN cord-015021-pol2qm74 2103 22 , , , cord-015021-pol2qm74 2103 23 cellular cellular JJ cord-015021-pol2qm74 2103 24 proliferation proliferation NN cord-015021-pol2qm74 2103 25 , , , cord-015021-pol2qm74 2103 26 and and CC cord-015021-pol2qm74 2103 27 acute acute JJ cord-015021-pol2qm74 2103 28 phase phase NN cord-015021-pol2qm74 2103 29 protein protein NN cord-015021-pol2qm74 2103 30 expression expression NN cord-015021-pol2qm74 2103 31 by by IN cord-015021-pol2qm74 2103 32 radioimmunoprecipitation radioimmunoprecipitation NN cord-015021-pol2qm74 2103 33 and and CC cord-015021-pol2qm74 2103 34 two two CD cord-015021-pol2qm74 2103 35 dimensional dimensional JJ cord-015021-pol2qm74 2103 36 gel gel NN cord-015021-pol2qm74 2103 37 electrophoresis electrophoresis NN cord-015021-pol2qm74 2103 38 . . . cord-015021-pol2qm74 2104 1 Scatchard Scatchard NNP cord-015021-pol2qm74 2104 2 analysis analysis NN cord-015021-pol2qm74 2104 3 demonstrated demonstrate VBD cord-015021-pol2qm74 2104 4 that that IN cord-015021-pol2qm74 2104 5 high high JJ cord-015021-pol2qm74 2104 6 affinity affinity NN cord-015021-pol2qm74 2104 7 receptor receptor NN cord-015021-pol2qm74 2104 8 expression expression NN cord-015021-pol2qm74 2104 9 was be VBD cord-015021-pol2qm74 2104 10 inhibited inhibit VBN cord-015021-pol2qm74 2104 11 by by IN cord-015021-pol2qm74 2104 12 incubation incubation NN cord-015021-pol2qm74 2104 13 of of IN cord-015021-pol2qm74 2104 14 cells cell NNS cord-015021-pol2qm74 2104 15 with with IN cord-015021-pol2qm74 2104 16 ASGP ASGP NNP cord-015021-pol2qm74 2104 17 - - HYPH cord-015021-pol2qm74 2104 18 PLL PLL NNP cord-015021-pol2qm74 2104 19 - - HYPH cord-015021-pol2qm74 2104 20 ASI ASI NNP cord-015021-pol2qm74 2105 1 For for IN cord-015021-pol2qm74 2105 2 24 24 CD cord-015021-pol2qm74 2105 3 h. h. NN cord-015021-pol2qm74 2105 4 Underivatized Underivatized NNP cord-015021-pol2qm74 2105 5 ASl ASl NNS cord-015021-pol2qm74 2105 6 was be VBD cord-015021-pol2qm74 2105 7 less less RBR cord-015021-pol2qm74 2105 8 effective effective JJ cord-015021-pol2qm74 2105 9 and and CC cord-015021-pol2qm74 2106 1 the the DT cord-015021-pol2qm74 2106 2 complex complex NN cord-015021-pol2qm74 2106 3 , , , cord-015021-pol2qm74 2106 4 ASGP ASGP NNP cord-015021-pol2qm74 2106 5 - - HYPH cord-015021-pol2qm74 2106 6 PLL PLL NNP cord-015021-pol2qm74 2106 7 - - HYPH cord-015021-pol2qm74 2106 8 AS2 AS2 NNP cord-015021-pol2qm74 2106 9 , , , cord-015021-pol2qm74 2106 10 had have VBD cord-015021-pol2qm74 2106 11 minimal minimal JJ cord-015021-pol2qm74 2106 12 effects effect NNS cord-015021-pol2qm74 2106 13 on on IN cord-015021-pol2qm74 2106 14 high high JJ cord-015021-pol2qm74 2106 15 affinity affinity NN cord-015021-pol2qm74 2106 16 binding binding NN cord-015021-pol2qm74 2106 17 . . . cord-015021-pol2qm74 2107 1 When when WRB cord-015021-pol2qm74 2107 2 the the DT cord-015021-pol2qm74 2107 3 cells cell NNS cord-015021-pol2qm74 2107 4 were be VBD cord-015021-pol2qm74 2107 5 treated treat VBN cord-015021-pol2qm74 2107 6 with with IN cord-015021-pol2qm74 2107 7 the the DT cord-015021-pol2qm74 2107 8 conjugates conjugate NNS cord-015021-pol2qm74 2107 9 and and CC cord-015021-pol2qm74 2107 10 stimulated stimulate VBN cord-015021-pol2qm74 2107 11 with with IN cord-015021-pol2qm74 2107 12 IL-6 IL-6 NNP cord-015021-pol2qm74 2107 13 ( ( -LRB- cord-015021-pol2qm74 2107 14 i00 i00 JJ cord-015021-pol2qm74 2107 15 units unit NNS cord-015021-pol2qm74 2107 16 ) ) -RRB- cord-015021-pol2qm74 2108 1 ASGP ASGP NNP cord-015021-pol2qm74 2108 2 - - HYPH cord-015021-pol2qm74 2108 3 PLL PLL NNP cord-015021-pol2qm74 2108 4 - - HYPH cord-015021-pol2qm74 2108 5 ASI ASI NNP cord-015021-pol2qm74 2108 6 alone alone RB cord-015021-pol2qm74 2108 7 showed show VBD cord-015021-pol2qm74 2108 8 a a DT cord-015021-pol2qm74 2108 9 dose dose NN cord-015021-pol2qm74 2108 10 dependent dependent JJ cord-015021-pol2qm74 2108 11 ( ( -LRB- cord-015021-pol2qm74 2108 12 0.i-0.4 0.i-0.4 CD cord-015021-pol2qm74 2109 1 ~M ~M NFP cord-015021-pol2qm74 2109 2 ) ) -RRB- cord-015021-pol2qm74 2109 3 inhibition inhibition NN cord-015021-pol2qm74 2109 4 of of IN cord-015021-pol2qm74 2109 5 3SS 3ss CD cord-015021-pol2qm74 2109 6 fibrinogen fibrinogen NN cord-015021-pol2qm74 2109 7 synthesis synthesis NN cord-015021-pol2qm74 2109 8 . . . cord-015021-pol2qm74 2110 1 Two two CD cord-015021-pol2qm74 2110 2 dimensional dimensional JJ cord-015021-pol2qm74 2110 3 gel gel NN cord-015021-pol2qm74 2110 4 electrophoresis electrophoresis NN cord-015021-pol2qm74 2110 5 showed show VBD cord-015021-pol2qm74 2110 6 that that IN cord-015021-pol2qm74 2110 7 expression expression NN cord-015021-pol2qm74 2110 8 of of IN cord-015021-pol2qm74 2110 9 other other JJ cord-015021-pol2qm74 2110 10 acute acute JJ cord-015021-pol2qm74 2110 11 phase phase NN cord-015021-pol2qm74 2110 12 proteins protein NNS cord-015021-pol2qm74 2110 13 was be VBD cord-015021-pol2qm74 2110 14 also also RB cord-015021-pol2qm74 2110 15 blocked block VBN cord-015021-pol2qm74 2110 16 . . . cord-015021-pol2qm74 2111 1 These these DT cord-015021-pol2qm74 2111 2 results result NNS cord-015021-pol2qm74 2111 3 indicate indicate VBP cord-015021-pol2qm74 2111 4 that that IN cord-015021-pol2qm74 2111 5 the the DT cord-015021-pol2qm74 2111 6 targeted target VBN cord-015021-pol2qm74 2111 7 delivery delivery NN cord-015021-pol2qm74 2111 8 of of IN cord-015021-pol2qm74 2111 9 antisense antisense NN cord-015021-pol2qm74 2111 10 molecules molecule NNS cord-015021-pol2qm74 2111 11 via via IN cord-015021-pol2qm74 2111 12 conjugates conjugate NNS cord-015021-pol2qm74 2111 13 recognized recognize VBN cord-015021-pol2qm74 2111 14 by by IN cord-015021-pol2qm74 2111 15 the the DT cord-015021-pol2qm74 2111 16 asialoglycoprotein asialoglycoprotein NNP cord-015021-pol2qm74 2111 17 receptor receptor NN cord-015021-pol2qm74 2111 18 can can MD cord-015021-pol2qm74 2111 19 block block VB cord-015021-pol2qm74 2111 20 the the DT cord-015021-pol2qm74 2111 21 cytokine cytokine NN cord-015021-pol2qm74 2111 22 stimulated stimulate VBD cord-015021-pol2qm74 2111 23 acute acute JJ cord-015021-pol2qm74 2111 24 phase phase NN cord-015021-pol2qm74 2111 25 protein protein NN cord-015021-pol2qm74 2111 26 response response NN cord-015021-pol2qm74 2111 27 in in IN cord-015021-pol2qm74 2111 28 hepatocytes hepatocyte NNS cord-015021-pol2qm74 2111 29 , , , cord-015021-pol2qm74 2111 30 This this DT cord-015021-pol2qm74 2111 31 approach approach NN cord-015021-pol2qm74 2111 32 may may MD cord-015021-pol2qm74 2111 33 be be VB cord-015021-pol2qm74 2111 34 relevant relevant JJ cord-015021-pol2qm74 2111 35 to to IN cord-015021-pol2qm74 2111 36 the the DT cord-015021-pol2qm74 2111 37 therapeutic therapeutic JJ cord-015021-pol2qm74 2111 38 management management NN cord-015021-pol2qm74 2111 39 of of IN cord-015021-pol2qm74 2111 40 patients patient NNS cord-015021-pol2qm74 2111 41 with with IN cord-015021-pol2qm74 2111 42 severe severe JJ cord-015021-pol2qm74 2111 43 injury injury NN cord-015021-pol2qm74 2111 44 and and CC cord-015021-pol2qm74 2111 45 sepsis sepsis NN cord-015021-pol2qm74 2111 46 . . . cord-015021-pol2qm74 2112 1 It -PRON- PRP cord-015021-pol2qm74 2112 2 has have VBZ cord-015021-pol2qm74 2112 3 been be VBN cord-015021-pol2qm74 2112 4 established establish VBN cord-015021-pol2qm74 2112 5 that that IN cord-015021-pol2qm74 2112 6 immune immune JJ cord-015021-pol2qm74 2112 7 cells cell NNS cord-015021-pol2qm74 2112 8 are be VBP cord-015021-pol2qm74 2112 9 able able JJ cord-015021-pol2qm74 2112 10 to to TO cord-015021-pol2qm74 2112 11 express express VB cord-015021-pol2qm74 2112 12 neuropeptide neuropeptide NN cord-015021-pol2qm74 2112 13 genes gene NNS cord-015021-pol2qm74 2112 14 and and CC cord-015021-pol2qm74 2112 15 to to TO cord-015021-pol2qm74 2112 16 release release VB cord-015021-pol2qm74 2112 17 products product NNS cord-015021-pol2qm74 2112 18 that that WDT cord-015021-pol2qm74 2112 19 were be VBD cord-015021-pol2qm74 2112 20 considered consider VBN cord-015021-pol2qm74 2112 21 to to TO cord-015021-pol2qm74 2112 22 be be VB cord-015021-pol2qm74 2112 23 of of IN cord-015021-pol2qm74 2112 24 neuroendocrine neuroendocrine JJ cord-015021-pol2qm74 2112 25 origin origin NN cord-015021-pol2qm74 2112 26 . . . cord-015021-pol2qm74 2113 1 We -PRON- PRP cord-015021-pol2qm74 2113 2 have have VBP cord-015021-pol2qm74 2113 3 shown show VBN cord-015021-pol2qm74 2113 4 that that IN cord-015021-pol2qm74 2113 5 Proenkephalin Proenkephalin NNP cord-015021-pol2qm74 2113 6 ( ( -LRB- cord-015021-pol2qm74 2113 7 PENK PENK NNP cord-015021-pol2qm74 2113 8 ) ) -RRB- cord-015021-pol2qm74 2113 9 , , , cord-015021-pol2qm74 2113 10 a a DT cord-015021-pol2qm74 2113 11 neuropeptide neuropeptide NN cord-015021-pol2qm74 2113 12 encoding encoding NN cord-015021-pol2qm74 2113 13 gene gene NN cord-015021-pol2qm74 2113 14 , , , cord-015021-pol2qm74 2113 15 is be VBZ cord-015021-pol2qm74 2113 16 expressed express VBN cord-015021-pol2qm74 2113 17 in in IN cord-015021-pol2qm74 2113 18 lymphoid lymphoid JJ cord-015021-pol2qm74 2113 19 cells cell NNS cord-015021-pol2qm74 2113 20 in in IN cord-015021-pol2qm74 2113 21 culture culture NN cord-015021-pol2qm74 2113 22 . . . cord-015021-pol2qm74 2114 1 To to TO cord-015021-pol2qm74 2114 2 study study VB cord-015021-pol2qm74 2114 3 the the DT cord-015021-pol2qm74 2114 4 physiological physiological JJ cord-015021-pol2qm74 2114 5 significance significance NN cord-015021-pol2qm74 2114 6 of of IN cord-015021-pol2qm74 2114 7 these these DT cord-015021-pol2qm74 2114 8 observations observation NNS cord-015021-pol2qm74 2114 9 we -PRON- PRP cord-015021-pol2qm74 2114 10 have have VBP cord-015021-pol2qm74 2114 11 used use VBN cord-015021-pol2qm74 2114 12 the the DT cord-015021-pol2qm74 2114 13 model model NN cord-015021-pol2qm74 2114 14 of of IN cord-015021-pol2qm74 2114 15 experimental experimental JJ cord-015021-pol2qm74 2114 16 endotoxemia endotoxemia NN cord-015021-pol2qm74 2114 17 . . . cord-015021-pol2qm74 2115 1 In in IN cord-015021-pol2qm74 2115 2 this this DT cord-015021-pol2qm74 2115 3 model model NN cord-015021-pol2qm74 2115 4 , , , cord-015021-pol2qm74 2115 5 a a DT cord-015021-pol2qm74 2115 6 disease disease NN cord-015021-pol2qm74 2115 7 state state NN cord-015021-pol2qm74 2115 8 is be VBZ cord-015021-pol2qm74 2115 9 induced induce VBN cord-015021-pol2qm74 2115 10 by by IN cord-015021-pol2qm74 2115 11 bacterial bacterial JJ cord-015021-pol2qm74 2115 12 lipopolysaccharide lipopolysaccharide NN cord-015021-pol2qm74 2115 13 ( ( -LRB- cord-015021-pol2qm74 2115 14 LPS LPS NNP cord-015021-pol2qm74 2115 15 ) ) -RRB- cord-015021-pol2qm74 2115 16 , , , cord-015021-pol2qm74 2115 17 that that WDT cord-015021-pol2qm74 2115 18 activates activate VBZ cord-015021-pol2qm74 2115 19 the the DT cord-015021-pol2qm74 2115 20 immune immune JJ cord-015021-pol2qm74 2115 21 system system NN cord-015021-pol2qm74 2115 22 , , , cord-015021-pol2qm74 2115 23 the the DT cord-015021-pol2qm74 2115 24 adrenocortical adrenocortical JJ cord-015021-pol2qm74 2115 25 axis axis NN cord-015021-pol2qm74 2115 26 and and CC cord-015021-pol2qm74 2115 27 the the DT cord-015021-pol2qm74 2115 28 nervous nervous JJ cord-015021-pol2qm74 2115 29 system system NN cord-015021-pol2qm74 2115 30 . . . cord-015021-pol2qm74 2116 1 We -PRON- PRP cord-015021-pol2qm74 2116 2 found find VBD cord-015021-pol2qm74 2116 3 that that IN cord-015021-pol2qm74 2116 4 the the DT cord-015021-pol2qm74 2116 5 expression expression NN cord-015021-pol2qm74 2116 6 of of IN cord-015021-pol2qm74 2116 7 PENKmRNA penkmrna NN cord-015021-pol2qm74 2116 8 is be VBZ cord-015021-pol2qm74 2116 9 markedly markedly RB cord-015021-pol2qm74 2116 10 enhanced enhance VBN cord-015021-pol2qm74 2116 11 in in IN cord-015021-pol2qm74 2116 12 vivo vivo NN cord-015021-pol2qm74 2116 13 immediately immediately RB cord-015021-pol2qm74 2116 14 after after IN cord-015021-pol2qm74 2116 15 LPS lp NNS cord-015021-pol2qm74 2116 16 injection injection NN cord-015021-pol2qm74 2116 17 both both CC cord-015021-pol2qm74 2116 18 in in IN cord-015021-pol2qm74 2116 19 the the DT cord-015021-pol2qm74 2116 20 adrenal adrenal JJ cord-015021-pol2qm74 2116 21 glands gland NNS cord-015021-pol2qm74 2116 22 and and CC cord-015021-pol2qm74 2116 23 in in IN cord-015021-pol2qm74 2116 24 the the DT cord-015021-pol2qm74 2116 25 lymph lymph NN cord-015021-pol2qm74 2116 26 nodes node NNS cord-015021-pol2qm74 2116 27 . . . cord-015021-pol2qm74 2117 1 In in IN cord-015021-pol2qm74 2117 2 situ situ JJ cord-015021-pol2qm74 2117 3 hybridization hybridization NN cord-015021-pol2qm74 2117 4 analysis analysis NN cord-015021-pol2qm74 2117 5 combined combine VBN cord-015021-pol2qm74 2117 6 with with IN cord-015021-pol2qm74 2117 7 immunohisto immunohisto NN cord-015021-pol2qm74 2117 8 - - HYPH cord-015021-pol2qm74 2117 9 chemistry chemistry NNP cord-015021-pol2qm74 2117 10 indicated indicate VBD cord-015021-pol2qm74 2117 11 that that IN cord-015021-pol2qm74 2117 12 the the DT cord-015021-pol2qm74 2117 13 induced induce VBN cord-015021-pol2qm74 2117 14 PENK PENK NNP cord-015021-pol2qm74 2117 15 expression expression NN cord-015021-pol2qm74 2117 16 is be VBZ cord-015021-pol2qm74 2117 17 confined confine VBN cord-015021-pol2qm74 2117 18 to to IN cord-015021-pol2qm74 2117 19 macrephages macrephage NNS cord-015021-pol2qm74 2117 20 within within IN cord-015021-pol2qm74 2117 21 the the DT cord-015021-pol2qm74 2117 22 lymph lymph NN cord-015021-pol2qm74 2117 23 nodes node NNS cord-015021-pol2qm74 2117 24 and and CC cord-015021-pol2qm74 2117 25 chromaffin chromaffin NN cord-015021-pol2qm74 2117 26 cells cell NNS cord-015021-pol2qm74 2117 27 in in IN cord-015021-pol2qm74 2117 28 the the DT cord-015021-pol2qm74 2117 29 adrenal adrenal JJ cord-015021-pol2qm74 2117 30 medulla medulla NN cord-015021-pol2qm74 2117 31 . . . cord-015021-pol2qm74 2118 1 Furthermore furthermore RB cord-015021-pol2qm74 2118 2 , , , cord-015021-pol2qm74 2118 3 this this DT cord-015021-pol2qm74 2118 4 expression expression NN cord-015021-pol2qm74 2118 5 in in IN cord-015021-pol2qm74 2118 6 lymph lymph NN cord-015021-pol2qm74 2118 7 nodes node NNS cord-015021-pol2qm74 2118 8 is be VBZ cord-015021-pol2qm74 2118 9 modulated modulate VBN cord-015021-pol2qm74 2118 10 by by IN cord-015021-pol2qm74 2118 11 ligands ligand NNS cord-015021-pol2qm74 2118 12 of of IN cord-015021-pol2qm74 2118 13 the the DT cord-015021-pol2qm74 2118 14 adrenergic adrenergic JJ cord-015021-pol2qm74 2118 15 system system NN cord-015021-pol2qm74 2118 16 . . . cord-015021-pol2qm74 2119 1 Our -PRON- PRP$ cord-015021-pol2qm74 2119 2 results result NNS cord-015021-pol2qm74 2119 3 strongly strongly RB cord-015021-pol2qm74 2119 4 support support VBP cord-015021-pol2qm74 2119 5 the the DT cord-015021-pol2qm74 2119 6 notion notion NN cord-015021-pol2qm74 2119 7 that that IN cord-015021-pol2qm74 2119 8 immune immune JJ cord-015021-pol2qm74 2119 9 derived derive VBN cord-015021-pol2qm74 2119 10 opioids opioid NNS cord-015021-pol2qm74 2119 11 participate participate VBP cord-015021-pol2qm74 2119 12 in in IN cord-015021-pol2qm74 2119 13 the the DT cord-015021-pol2qm74 2119 14 bidirectional bidirectional JJ cord-015021-pol2qm74 2119 15 communication communication NN cord-015021-pol2qm74 2119 16 between between IN cord-015021-pol2qm74 2119 17 the the DT cord-015021-pol2qm74 2119 18 nervous nervous JJ cord-015021-pol2qm74 2119 19 and and CC cord-015021-pol2qm74 2119 20 immune immune JJ cord-015021-pol2qm74 2119 21 systems system NNS cord-015021-pol2qm74 2119 22 . . . cord-015021-pol2qm74 2120 1 of of IN cord-015021-pol2qm74 2120 2 Neurology Neurology NNP cord-015021-pol2qm74 2120 3 Hadassah Hadassah NNP cord-015021-pol2qm74 2120 4 University University NNP cord-015021-pol2qm74 2120 5 Hospital Hospital NNP cord-015021-pol2qm74 2120 6 , , , cord-015021-pol2qm74 2120 7 Jerusalem Jerusalem NNP cord-015021-pol2qm74 2120 8 91120 91120 CD cord-015021-pol2qm74 2120 9 , , , cord-015021-pol2qm74 2120 10 Israel Israel NNP cord-015021-pol2qm74 2120 11 . . . cord-015021-pol2qm74 2121 1 Objectives objective NNS cord-015021-pol2qm74 2121 2 of of IN cord-015021-pol2qm74 2121 3 the the DT cord-015021-pol2qm74 2121 4 study study NN cord-015021-pol2qm74 2121 5 : : : cord-015021-pol2qm74 2121 6 Multiple multiple JJ cord-015021-pol2qm74 2121 7 - - HYPH cord-015021-pol2qm74 2121 8 organ organ NN cord-015021-pol2qm74 2121 9 - - HYPH cord-015021-pol2qm74 2121 10 failure failure NN cord-015021-pol2qm74 2121 11 is be VBZ cord-015021-pol2qm74 2121 12 recognized recognize VBN cord-015021-pol2qm74 2121 13 as as IN cord-015021-pol2qm74 2121 14 the the DT cord-015021-pol2qm74 2121 15 most most RBS cord-015021-pol2qm74 2121 16 severe severe JJ cord-015021-pol2qm74 2121 17 , , , cord-015021-pol2qm74 2121 18 and and CC cord-015021-pol2qm74 2121 19 often often RB cord-015021-pol2qm74 2121 20 lethal lethal JJ cord-015021-pol2qm74 2121 21 , , , cord-015021-pol2qm74 2121 22 complication complication NN cord-015021-pol2qm74 2121 23 after after IN cord-015021-pol2qm74 2121 24 multiple multiple JJ cord-015021-pol2qm74 2121 25 trauma trauma NN cord-015021-pol2qm74 2121 26 . . . cord-015021-pol2qm74 2122 1 However however RB cord-015021-pol2qm74 2122 2 there there EX cord-015021-pol2qm74 2122 3 is be VBZ cord-015021-pol2qm74 2122 4 no no DT cord-015021-pol2qm74 2122 5 adeqate adeqate NNP cord-015021-pol2qm74 2122 6 animal animal NN cord-015021-pol2qm74 2122 7 model model NN cord-015021-pol2qm74 2122 8 available available JJ cord-015021-pol2qm74 2122 9 . . . cord-015021-pol2qm74 2123 1 Our -PRON- PRP$ cord-015021-pol2qm74 2123 2 goal goal NN cord-015021-pol2qm74 2123 3 was be VBD cord-015021-pol2qm74 2123 4 to to TO cord-015021-pol2qm74 2123 5 develop develop VB cord-015021-pol2qm74 2123 6 an an DT cord-015021-pol2qm74 2123 7 animal animal NN cord-015021-pol2qm74 2123 8 model model NN cord-015021-pol2qm74 2123 9 , , , cord-015021-pol2qm74 2123 10 in in IN cord-015021-pol2qm74 2123 11 which which WDT cord-015021-pol2qm74 2123 12 reproducable reproducable JJ cord-015021-pol2qm74 2123 13 irreversible irreversible JJ cord-015021-pol2qm74 2123 14 failure failure NN cord-015021-pol2qm74 2123 15 of of IN cord-015021-pol2qm74 2123 16 parenchymal parenchymal JJ cord-015021-pol2qm74 2123 17 organs organ NNS cord-015021-pol2qm74 2123 18 is be VBZ cord-015021-pol2qm74 2123 19 achieved achieve VBN cord-015021-pol2qm74 2123 20 in in IN cord-015021-pol2qm74 2123 21 the the DT cord-015021-pol2qm74 2123 22 late late JJ cord-015021-pol2qm74 2123 23 phase phase NN cord-015021-pol2qm74 2123 24 after after IN cord-015021-pol2qm74 2123 25 insults insult NNS cord-015021-pol2qm74 2123 26 in in IN cord-015021-pol2qm74 2123 27 the the DT cord-015021-pol2qm74 2123 28 early early JJ cord-015021-pol2qm74 2123 29 phase phase NN cord-015021-pol2qm74 2123 30 ( ( -LRB- cord-015021-pol2qm74 2123 31 trauma trauma NN cord-015021-pol2qm74 2123 32 ) ) -RRB- cord-015021-pol2qm74 2123 33 . . . cord-015021-pol2qm74 2124 1 Materials material NNS cord-015021-pol2qm74 2124 2 and and CC cord-015021-pol2qm74 2124 3 methods method NNS cord-015021-pol2qm74 2124 4 : : : cord-015021-pol2qm74 2124 5 l0 l0 NNP cord-015021-pol2qm74 2124 6 female female NNP cord-015021-pol2qm74 2124 7 Merino Merino NNP cord-015021-pol2qm74 2124 8 - - HYPH cord-015021-pol2qm74 2124 9 sheep sheep NN cord-015021-pol2qm74 2124 10 were be VBD cord-015021-pol2qm74 2124 11 included include VBN cord-015021-pol2qm74 2124 12 ( ( -LRB- cord-015021-pol2qm74 2124 13 mean mean VB cord-015021-pol2qm74 2124 14 weight weight NN cord-015021-pol2qm74 2124 15 : : : cord-015021-pol2qm74 2124 16 30 30 CD cord-015021-pol2qm74 2124 17 kg kg NN cord-015021-pol2qm74 2124 18 ) ) -RRB- cord-015021-pol2qm74 2124 19 . . . cord-015021-pol2qm74 2125 1 day day NN cord-015021-pol2qm74 2125 2 0 0 CD cord-015021-pol2qm74 2125 3 : : : cord-015021-pol2qm74 2125 4 hemorrhagic hemorrhagic JJ cord-015021-pol2qm74 2125 5 shock shock NN cord-015021-pol2qm74 2125 6 ( ( -LRB- cord-015021-pol2qm74 2125 7 mean mean VB cord-015021-pol2qm74 2125 8 arterial arterial JJ cord-015021-pol2qm74 2125 9 pressure pressure NN cord-015021-pol2qm74 2125 10 ( ( -LRB- cord-015021-pol2qm74 2125 11 MAP MAP NNP cord-015021-pol2qm74 2125 12 ) ) -RRB- cord-015021-pol2qm74 2125 13 50mmHg 50mmhg CD cord-015021-pol2qm74 2125 14 for for IN cord-015021-pol2qm74 2125 15 2 2 CD cord-015021-pol2qm74 2125 16 hrs hrs NN cord-015021-pol2qm74 2125 17 . . . cord-015021-pol2qm74 2125 18 ) ) -RRB- cord-015021-pol2qm74 2125 19 , , , cord-015021-pol2qm74 2125 20 closed closed JJ cord-015021-pol2qm74 2125 21 femoral femoral JJ cord-015021-pol2qm74 2125 22 nailing nailing NN cord-015021-pol2qm74 2125 23 ( ( -LRB- cord-015021-pol2qm74 2125 24 AO ao NN cord-015021-pol2qm74 2125 25 - - HYPH cord-015021-pol2qm74 2125 26 technique technique NN cord-015021-pol2qm74 2125 27 ) ) -RRB- cord-015021-pol2qm74 2125 28 , , , cord-015021-pol2qm74 2125 29 day day NN cord-015021-pol2qm74 2125 30 1 1 CD cord-015021-pol2qm74 2125 31 - - SYM cord-015021-pol2qm74 2125 32 5 5 CD cord-015021-pol2qm74 2125 33 : : : cord-015021-pol2qm74 2126 1 bolusinjection bolusinjection NN cord-015021-pol2qm74 2126 2 of of IN cord-015021-pol2qm74 2126 3 endotoxin endotoxin NN cord-015021-pol2qm74 2126 4 ( ( -LRB- cord-015021-pol2qm74 2126 5 ET et NN cord-015021-pol2qm74 2126 6 ) ) -RRB- cord-015021-pol2qm74 2127 1 ( ( -LRB- cord-015021-pol2qm74 2127 2 0,75~tg 0,75~tg CD cord-015021-pol2qm74 2127 3 / / SYM cord-015021-pol2qm74 2127 4 kgBW kgBW NNP cord-015021-pol2qm74 2127 5 ) ) -RRB- cord-015021-pol2qm74 2128 1 und und NNP cord-015021-pol2qm74 2128 2 zymosan zymosan NNP cord-015021-pol2qm74 2128 3 - - HYPH cord-015021-pol2qm74 2128 4 activated activate VBN cord-015021-pol2qm74 2128 5 plasma plasma NN cord-015021-pol2qm74 2128 6 ( ( -LRB- cord-015021-pol2qm74 2128 7 ZAP ZAP NNP cord-015021-pol2qm74 2128 8 ) ) -RRB- cord-015021-pol2qm74 2128 9 ( ( -LRB- cord-015021-pol2qm74 2128 10 20ml 20ml LS cord-015021-pol2qm74 2128 11 ) ) -RRB- cord-015021-pol2qm74 2129 1 every every DT cord-015021-pol2qm74 2129 2 12hrs 12hrs NN cord-015021-pol2qm74 2129 3 . . . cord-015021-pol2qm74 2130 1 , , , cord-015021-pol2qm74 2130 2 day day NN cord-015021-pol2qm74 2130 3 6 6 CD cord-015021-pol2qm74 2130 4 - - SYM cord-015021-pol2qm74 2130 5 10 10 CD cord-015021-pol2qm74 2130 6 : : : cord-015021-pol2qm74 2130 7 observation observation NN cord-015021-pol2qm74 2130 8 . . . cord-015021-pol2qm74 2131 1 Bronchoalveolar Bronchoalveolar NNP cord-015021-pol2qm74 2131 2 lavage lavage NN cord-015021-pol2qm74 2131 3 ( ( -LRB- cord-015021-pol2qm74 2131 4 BAL bal NN cord-015021-pol2qm74 2131 5 ) ) -RRB- cord-015021-pol2qm74 2131 6 : : : cord-015021-pol2qm74 2131 7 day day NN cord-015021-pol2qm74 2131 8 1 1 CD cord-015021-pol2qm74 2131 9 , , , cord-015021-pol2qm74 2131 10 6 6 CD cord-015021-pol2qm74 2131 11 , , , cord-015021-pol2qm74 2131 12 10 10 CD cord-015021-pol2qm74 2131 13 . . . cord-015021-pol2qm74 2132 1 The the DT cord-015021-pol2qm74 2132 2 course course NN cord-015021-pol2qm74 2132 3 of of IN cord-015021-pol2qm74 2132 4 representative representative JJ cord-015021-pol2qm74 2132 5 parameters parameter NNS cord-015021-pol2qm74 2132 6 of of IN cord-015021-pol2qm74 2132 7 organ organ NN cord-015021-pol2qm74 2132 8 function function NN cord-015021-pol2qm74 2132 9 was be VBD cord-015021-pol2qm74 2132 10 documented document VBN cord-015021-pol2qm74 2132 11 : : : cord-015021-pol2qm74 2132 12 COcardiac COcardiac NNP cord-015021-pol2qm74 2132 13 output output NN cord-015021-pol2qm74 2132 14 ( ( -LRB- cord-015021-pol2qm74 2132 15 I i NN cord-015021-pol2qm74 2132 16 / / SYM cord-015021-pol2qm74 2132 17 min min NNP cord-015021-pol2qm74 2132 18 ) ) -RRB- cord-015021-pol2qm74 2132 19 , , , cord-015021-pol2qm74 2132 20 SVR SVR NNP cord-015021-pol2qm74 2132 21 -systemic -systemic JJ cord-015021-pol2qm74 2132 22 vascular vascular JJ cord-015021-pol2qm74 2132 23 resistence resistence NN cord-015021-pol2qm74 2132 24 ( ( -LRB- cord-015021-pol2qm74 2132 25 dyn dyn NNP cord-015021-pol2qm74 2132 26 ~ ~ NNP cord-015021-pol2qm74 2132 27 s s NNP cord-015021-pol2qm74 2132 28 cm-5 cm-5 NN cord-015021-pol2qm74 2132 29 ) ) -RRB- cord-015021-pol2qm74 2133 1 , , , cord-015021-pol2qm74 2133 2 PAP pap NN cord-015021-pol2qm74 2133 3 -putm.art.pressure -putm.art.pressure NN cord-015021-pol2qm74 2133 4 ( ( -LRB- cord-015021-pol2qm74 2133 5 mmHg mmHg NNP cord-015021-pol2qm74 2133 6 ) ) -RRB- cord-015021-pol2qm74 2133 7 , , , cord-015021-pol2qm74 2133 8 PaP2 pap2 JJ cord-015021-pol2qm74 2133 9 -arterial -arterial JJ cord-015021-pol2qm74 2133 10 oxygen oxygen NN cord-015021-pol2qm74 2133 11 pressure pressure NN cord-015021-pol2qm74 2133 12 ( ( -LRB- cord-015021-pol2qm74 2133 13 mmHg mmHg NNP cord-015021-pol2qm74 2133 14 ) ) -RRB- cord-015021-pol2qm74 2133 15 , , . cord-015021-pol2qm74 2134 1 Bill Bill NNP cord-015021-pol2qm74 2134 2 -Bilirubin -Bilirubin . cord-015021-pol2qm74 2135 1 ( ( -LRB- cord-015021-pol2qm74 2135 2 ; ; : cord-015021-pol2qm74 2135 3 xmoV1 xmov1 ADD cord-015021-pol2qm74 2135 4 ) ) -RRB- cord-015021-pol2qm74 2135 5 , , , cord-015021-pol2qm74 2135 6 CrCI CrCI NNP cord-015021-pol2qm74 2135 7 -Creatinin -Creatinin VBZ cord-015021-pol2qm74 2135 8 Clearence Clearence NNP cord-015021-pol2qm74 2135 9 ( ( -LRB- cord-015021-pol2qm74 2135 10 ml ml NN cord-015021-pol2qm74 2135 11 / / SYM cord-015021-pol2qm74 2135 12 min min NN cord-015021-pol2qm74 2135 13 ) ) -RRB- cord-015021-pol2qm74 2136 1 Statistics statistic NNS cord-015021-pol2qm74 2136 2 : : : cord-015021-pol2qm74 2136 3 Data datum NNS cord-015021-pol2qm74 2136 4 as as IN cord-015021-pol2qm74 2136 5 means+SEM means+SEM NNP cord-015021-pol2qm74 2136 6 , , , cord-015021-pol2qm74 2136 7 * * NFP cord-015021-pol2qm74 2136 8 significant significant JJ cord-015021-pol2qm74 2136 9 from from IN cord-015021-pol2qm74 2136 10 baseline baseline JJ cord-015021-pol2qm74 2136 11 ( ( -LRB- cord-015021-pol2qm74 2136 12 Wileoxon Wileoxon NNP cord-015021-pol2qm74 2136 13 Test test NN cord-015021-pol2qm74 2136 14 ; ; . cord-015021-pol2qm74 2137 1 p<0005 p<0005 NNP cord-015021-pol2qm74 2137 2 ) ) -RRB- cord-015021-pol2qm74 2137 3 Results result VBZ cord-015021-pol2qm74 2137 4 : : : cord-015021-pol2qm74 2137 5 baseline baseline JJ cord-015021-pol2qm74 2137 6 day day NN cord-015021-pol2qm74 2137 7 4 4 CD cord-015021-pol2qm74 2137 8 day day NN cord-015021-pol2qm74 2137 9 6 6 CD cord-015021-pol2qm74 2137 10 day day NN cord-015021-pol2qm74 2137 11 8 8 CD cord-015021-pol2qm74 2137 12 day day NN cord-015021-pol2qm74 2137 13 10 10 CD cord-015021-pol2qm74 2137 14 heart heart NN cord-015021-pol2qm74 2137 15 : : : cord-015021-pol2qm74 2137 16 CO CO NNP cord-015021-pol2qm74 2137 17 4,96_+0,32 4,96_+0,32 CD cord-015021-pol2qm74 2138 1 5,33_+0,36 5,33_+0,36 CD cord-015021-pol2qm74 2139 1 5,4_+0,2 5,4_+0,2 CD cord-015021-pol2qm74 2139 2 7,30_+0,77 7,30_+0,77 CD cord-015021-pol2qm74 2140 1 * * NFP cord-015021-pol2qm74 2141 1 7,98_+0,66 7,98_+0,66 LS cord-015021-pol2qm74 2142 1 * * NFP cord-015021-pol2qm74 2142 2 SVR1520_+134 SVR1520_+134 NNP cord-015021-pol2qm74 2142 3 1395 1395 CD cord-015021-pol2qm74 2142 4 + + SYM cord-015021-pol2qm74 2142 5 141 141 CD cord-015021-pol2qm74 2142 6 1403_+89 1403_+89 CD cord-015021-pol2qm74 2142 7 1119+_122 1119+_122 CD cord-015021-pol2qm74 2142 8 " " '' cord-015021-pol2qm74 2143 1 1089 1089 CD cord-015021-pol2qm74 2143 2 + + SYM cord-015021-pol2qm74 2143 3 -91 -91 NN cord-015021-pol2qm74 2143 4 " " `` cord-015021-pol2qm74 2143 5 lung lung NN cord-015021-pol2qm74 2143 6 : : : cord-015021-pol2qm74 2143 7 PAP PAP NNP cord-015021-pol2qm74 2143 8 17,0_-20,7 17,0_-20,7 CD cord-015021-pol2qm74 2143 9 19,6_+1,6 19,6_+1,6 CD cord-015021-pol2qm74 2143 10 " " '' cord-015021-pol2qm74 2143 11 22,0 22,0 CD cord-015021-pol2qm74 2144 1 + + CC cord-015021-pol2qm74 2145 1 -1,2"25,8 -1,2"25,8 XX cord-015021-pol2qm74 2146 1 +2,0 +2,0 DT cord-015021-pol2qm74 2147 1 " " `` cord-015021-pol2qm74 2147 2 28,8 28,8 CD cord-015021-pol2qm74 2147 3 + + CC cord-015021-pol2qm74 2148 1 -1,7 -1,7 : cord-015021-pol2qm74 2148 2 ' ' '' cord-015021-pol2qm74 2149 1 PaP2 PaP2 NNP cord-015021-pol2qm74 2150 1 103,1 103,1 CD cord-015021-pol2qm74 2150 2 + + CC cord-015021-pol2qm74 2150 3 1,5101,5 1,5101,5 CD cord-015021-pol2qm74 2151 1 + + CC cord-015021-pol2qm74 2151 2 -5,7 -5,7 . cord-015021-pol2qm74 2152 1 97,3_+4,7 97,3_+4,7 CD cord-015021-pol2qm74 2153 1 91,9 91,9 LS cord-015021-pol2qm74 2153 2 + + CC cord-015021-pol2qm74 2154 1 -5,6 -5,6 NNP cord-015021-pol2qm74 2155 1 89,8+_3,9 89,8+_3,9 LS cord-015021-pol2qm74 2155 2 * * NFP cord-015021-pol2qm74 2155 3 liver liver NN cord-015021-pol2qm74 2155 4 : : : cord-015021-pol2qm74 2155 5 Bill Bill NNP cord-015021-pol2qm74 2155 6 2 2 CD cord-015021-pol2qm74 2155 7 , , , cord-015021-pol2qm74 2155 8 94_+0 94_+0 CD cord-015021-pol2qm74 2155 9 , , , cord-015021-pol2qm74 2155 10 344 344 CD cord-015021-pol2qm74 2155 11 , , , cord-015021-pol2qm74 2155 12 82_+1 82_+1 CD cord-015021-pol2qm74 2155 13 , , , cord-015021-pol2qm74 2155 14 34 34 CD cord-015021-pol2qm74 2155 15 ' ' POS cord-015021-pol2qm74 2155 16 5 5 CD cord-015021-pol2qm74 2155 17 , , , cord-015021-pol2qm74 2155 18 13_+0 13_+0 CD cord-015021-pol2qm74 2155 19 , , , cord-015021-pol2qm74 2155 20 68'6 68'6 CD cord-015021-pol2qm74 2155 21 , , , cord-015021-pol2qm74 2155 22 13_+0 13_+0 CD cord-015021-pol2qm74 2155 23 , , , cord-015021-pol2qm74 2155 24 7 7 CD cord-015021-pol2qm74 2155 25 " " `` cord-015021-pol2qm74 2155 26 7 7 CD cord-015021-pol2qm74 2155 27 , , , cord-015021-pol2qm74 2155 28 19_+0 19_+0 CD cord-015021-pol2qm74 2155 29 , , , cord-015021-pol2qm74 2155 30 91 91 CD cord-015021-pol2qm74 2155 31 " " `` cord-015021-pol2qm74 2155 32 kidney kidney NN cord-015021-pol2qm74 2155 33 : : : cord-015021-pol2qm74 2155 34 CrCl CrCl NNP cord-015021-pol2qm74 2155 35 86 86 CD cord-015021-pol2qm74 2155 36 , , , cord-015021-pol2qm74 2155 37 5+_30 5+_30 NNP cord-015021-pol2qm74 2155 38 , , , cord-015021-pol2qm74 2155 39 9 9 CD cord-015021-pol2qm74 2155 40 109 109 CD cord-015021-pol2qm74 2155 41 , , , cord-015021-pol2qm74 2155 42 [ [ -LRB- cord-015021-pol2qm74 2155 43 8 8 CD cord-015021-pol2qm74 2155 44 ] ] -RRB- cord-015021-pol2qm74 2155 45 [ [ -LRB- cord-015021-pol2qm74 2155 46 9 9 CD cord-015021-pol2qm74 2155 47 ] ] -RRB- cord-015021-pol2qm74 2156 1 [ [ -LRB- cord-015021-pol2qm74 2156 2 10 10 CD cord-015021-pol2qm74 2156 3 ] ] -RRB- cord-015021-pol2qm74 2156 4 [ [ -LRB- cord-015021-pol2qm74 2156 5 11 11 CD cord-015021-pol2qm74 2156 6 ] ] -RRB- cord-015021-pol2qm74 2156 7 [ [ -LRB- cord-015021-pol2qm74 2156 8 12 12 CD cord-015021-pol2qm74 2156 9 ] ] -RRB- cord-015021-pol2qm74 2156 10 [ [ -LRB- cord-015021-pol2qm74 2156 11 13 13 CD cord-015021-pol2qm74 2156 12 ] ] -RRB- cord-015021-pol2qm74 2157 1 [ [ -LRB- cord-015021-pol2qm74 2157 2 14 14 CD cord-015021-pol2qm74 2157 3 ] ] -RRB- cord-015021-pol2qm74 2158 1 [ [ -LRB- cord-015021-pol2qm74 2158 2 15 15 CD cord-015021-pol2qm74 2158 3 ] ] -RRB- cord-015021-pol2qm74 2158 4 [ [ -LRB- cord-015021-pol2qm74 2158 5 16 16 CD cord-015021-pol2qm74 2158 6 ] ] -RRB- cord-015021-pol2qm74 2158 7 [ [ -LRB- cord-015021-pol2qm74 2158 8 17 17 CD cord-015021-pol2qm74 2158 9 ] ] -RRB- cord-015021-pol2qm74 2158 10 [ [ -LRB- cord-015021-pol2qm74 2158 11 18 18 CD cord-015021-pol2qm74 2158 12 ] ] -RRB- cord-015021-pol2qm74 2158 13 [ [ -LRB- cord-015021-pol2qm74 2158 14 19 19 CD cord-015021-pol2qm74 2158 15 ] ] -RRB- cord-015021-pol2qm74 2158 16 4 4 CD cord-015021-pol2qm74 2158 17 74 74 CD cord-015021-pol2qm74 2158 18 , , , cord-015021-pol2qm74 2158 19 7_+10 7_+10 CD cord-015021-pol2qm74 2158 20 , , , cord-015021-pol2qm74 2158 21 868 868 CD cord-015021-pol2qm74 2158 22 , , , cord-015021-pol2qm74 2158 23 8 8 CD cord-015021-pol2qm74 2158 24 + + SYM cord-015021-pol2qm74 2158 25 14 14 CD cord-015021-pol2qm74 2158 26 , , , cord-015021-pol2qm74 2158 27 1 1 CD cord-015021-pol2qm74 2158 28 53 53 CD cord-015021-pol2qm74 2158 29 , , , cord-015021-pol2qm74 2158 30 1 1 CD cord-015021-pol2qm74 2158 31 + + SYM cord-015021-pol2qm74 2158 32 17 17 CD cord-015021-pol2qm74 2158 33 , , , cord-015021-pol2qm74 2158 34 6 6 CD cord-015021-pol2qm74 2158 35 Histologic Histologic NNP cord-015021-pol2qm74 2158 36 specimens specimen NNS cord-015021-pol2qm74 2158 37 showed show VBD cord-015021-pol2qm74 2158 38 all all DT cord-015021-pol2qm74 2158 39 signs sign NNS cord-015021-pol2qm74 2158 40 of of IN cord-015021-pol2qm74 2158 41 fulminant fulminant JJ cord-015021-pol2qm74 2158 42 MOF MOF NNP cord-015021-pol2qm74 2158 43 . . . cord-015021-pol2qm74 2159 1 Combination combination NN cord-015021-pol2qm74 2159 2 of of IN cord-015021-pol2qm74 2159 3 hemorrhagic hemorrhagic JJ cord-015021-pol2qm74 2159 4 shock shock NN cord-015021-pol2qm74 2159 5 , , , cord-015021-pol2qm74 2159 6 femoral femoral JJ cord-015021-pol2qm74 2159 7 nailing nailing NN cord-015021-pol2qm74 2159 8 , , , cord-015021-pol2qm74 2159 9 ET ET NNP cord-015021-pol2qm74 2159 10 und und IN cord-015021-pol2qm74 2159 11 ZAP ZAP NNP cord-015021-pol2qm74 2159 12 ( ( -LRB- cord-015021-pol2qm74 2159 13 insults insult NNS cord-015021-pol2qm74 2159 14 in in IN cord-015021-pol2qm74 2159 15 the the DT cord-015021-pol2qm74 2159 16 early early JJ cord-015021-pol2qm74 2159 17 phase phase NN cord-015021-pol2qm74 2159 18 ) ) -RRB- cord-015021-pol2qm74 2159 19 lead lead NN cord-015021-pol2qm74 2159 20 to to IN cord-015021-pol2qm74 2159 21 an an DT cord-015021-pol2qm74 2159 22 irreversible irreversible JJ cord-015021-pol2qm74 2159 23 organ organ NN cord-015021-pol2qm74 2159 24 failure failure NN cord-015021-pol2qm74 2159 25 in in IN cord-015021-pol2qm74 2159 26 the the DT cord-015021-pol2qm74 2159 27 late late JJ cord-015021-pol2qm74 2159 28 phase phase NN cord-015021-pol2qm74 2159 29 . . . cord-015021-pol2qm74 2160 1 Prostaglandin prostaglandin NN cord-015021-pol2qm74 2160 2 E e NN cord-015021-pol2qm74 2160 3 ( ( -LRB- cord-015021-pol2qm74 2160 4 PGE PGE NNP cord-015021-pol2qm74 2160 5 ) ) -RRB- cord-015021-pol2qm74 2160 6 levels level NNS cord-015021-pol2qm74 2160 7 are be VBP cord-015021-pol2qm74 2160 8 elevated elevate VBN cord-015021-pol2qm74 2160 9 by by IN cord-015021-pol2qm74 2160 10 trauma trauma NN cord-015021-pol2qm74 2160 11 , , , cord-015021-pol2qm74 2160 12 shock shock NN cord-015021-pol2qm74 2160 13 or or CC cord-015021-pol2qm74 2160 14 sepsis sepsis NN cord-015021-pol2qm74 2160 15 and and CC cord-015021-pol2qm74 2160 16 can can MD cord-015021-pol2qm74 2160 17 profoundly profoundly RB cord-015021-pol2qm74 2160 18 affect affect VB cord-015021-pol2qm74 2160 19 the the DT cord-015021-pol2qm74 2160 20 immune immune JJ cord-015021-pol2qm74 2160 21 response response NN cord-015021-pol2qm74 2160 22 . . . cord-015021-pol2qm74 2161 1 PGE2 PGE2 NNP cord-015021-pol2qm74 2161 2 is be VBZ cord-015021-pol2qm74 2161 3 produced produce VBN cord-015021-pol2qm74 2161 4 by by IN cord-015021-pol2qm74 2161 5 many many JJ cord-015021-pol2qm74 2161 6 cell cell NN cord-015021-pol2qm74 2161 7 types type NNS cord-015021-pol2qm74 2161 8 including include VBG cord-015021-pol2qm74 2161 9 fibroblasts fibroblast NNS cord-015021-pol2qm74 2161 10 , , , cord-015021-pol2qm74 2161 11 macrophages macrophage NNS cord-015021-pol2qm74 2161 12 , , , cord-015021-pol2qm74 2161 13 monoeytes monoeyte NNS cord-015021-pol2qm74 2161 14 , , , cord-015021-pol2qm74 2161 15 follicular follicular JJ cord-015021-pol2qm74 2161 16 dendritic dendritic JJ cord-015021-pol2qm74 2161 17 cells cell NNS cord-015021-pol2qm74 2161 18 , , , cord-015021-pol2qm74 2161 19 and and CC cord-015021-pol2qm74 2161 20 epithelial epithelial JJ cord-015021-pol2qm74 2161 21 cells cell NNS cord-015021-pol2qm74 2161 22 and and CC cord-015021-pol2qm74 2161 23 is be VBZ cord-015021-pol2qm74 2161 24 induced induce VBN cord-015021-pol2qm74 2161 25 by by IN cord-015021-pol2qm74 2161 26 IL IL NNP cord-015021-pol2qm74 2161 27 - - HYPH cord-015021-pol2qm74 2161 28 I I NNP cord-015021-pol2qm74 2161 29 , , , cord-015021-pol2qm74 2161 30 bacterial bacterial JJ cord-015021-pol2qm74 2161 31 LPS lp NNS cord-015021-pol2qm74 2161 32 , , , cord-015021-pol2qm74 2161 33 components component NNS cord-015021-pol2qm74 2161 34 of of IN cord-015021-pol2qm74 2161 35 the the DT cord-015021-pol2qm74 2161 36 complement complement NN cord-015021-pol2qm74 2161 37 cascade cascade NN cord-015021-pol2qm74 2161 38 , , , cord-015021-pol2qm74 2161 39 TNF TNF NNP cord-015021-pol2qm74 2161 40 , , , cord-015021-pol2qm74 2161 41 IL-6 IL-6 NNP cord-015021-pol2qm74 2161 42 and and CC cord-015021-pol2qm74 2161 43 crosslinking crosslinking NN cord-015021-pol2qm74 2161 44 of of IN cord-015021-pol2qm74 2161 45 surface surface NN cord-015021-pol2qm74 2161 46 Fc Fc NNP cord-015021-pol2qm74 2161 47 receptors receptor NNS cord-015021-pol2qm74 2161 48 for for IN cord-015021-pol2qm74 2161 49 IgG IgG NNP cord-015021-pol2qm74 2161 50 , , , cord-015021-pol2qm74 2161 51 IgA IgA NNP cord-015021-pol2qm74 2161 52 and and CC cord-015021-pol2qm74 2162 1 IgE. ige. NN cord-015021-pol2qm74 2163 1 Our -PRON- PRP$ cord-015021-pol2qm74 2163 2 research research NN cord-015021-pol2qm74 2163 3 has have VBZ cord-015021-pol2qm74 2163 4 shown show VBN cord-015021-pol2qm74 2163 5 that that IN cord-015021-pol2qm74 2163 6 PGE PGE NNP cord-015021-pol2qm74 2163 7 inhibits inhibit VBZ cord-015021-pol2qm74 2163 8 B b NN cord-015021-pol2qm74 2163 9 cell cell NN cord-015021-pol2qm74 2163 10 activation activation NN cord-015021-pol2qm74 2163 11 ( ( -LRB- cord-015021-pol2qm74 2163 12 specifically specifically RB cord-015021-pol2qm74 2163 13 enlargement enlargement NN cord-015021-pol2qm74 2163 14 , , , cord-015021-pol2qm74 2163 15 class class NN cord-015021-pol2qm74 2163 16 II II NNP cord-015021-pol2qm74 2163 17 ~C ~C NFP cord-015021-pol2qm74 2163 18 and and CC cord-015021-pol2qm74 2163 19 Fc~ Fc~ NNP cord-015021-pol2qm74 2163 20 RII RII NNP cord-015021-pol2qm74 2163 21 expression expression NN cord-015021-pol2qm74 2163 22 ) ) -RRB- cord-015021-pol2qm74 2163 23 , , , cord-015021-pol2qm74 2163 24 proliferation proliferation NN cord-015021-pol2qm74 2163 25 , , , cord-015021-pol2qm74 2163 26 IgM IgM NNP cord-015021-pol2qm74 2163 27 and and CC cord-015021-pol2qm74 2163 28 IgG3 IgG3 NNP cord-015021-pol2qm74 2163 29 responses response NNS cord-015021-pol2qm74 2163 30 , , , cord-015021-pol2qm74 2163 31 T t NN cord-015021-pol2qm74 2163 32 cell cell NN cord-015021-pol2qm74 2163 33 proliferation proliferation NN cord-015021-pol2qm74 2163 34 , , , cord-015021-pol2qm74 2163 35 and and CC cord-015021-pol2qm74 2163 36 IL-2 IL-2 NNP cord-015021-pol2qm74 2163 37 synthesis synthesis NN cord-015021-pol2qm74 2163 38 in in IN cord-015021-pol2qm74 2163 39 the the DT cord-015021-pol2qm74 2163 40 mouse mouse NN cord-015021-pol2qm74 2163 41 model model NN cord-015021-pol2qm74 2163 42 . . . cord-015021-pol2qm74 2164 1 In in IN cord-015021-pol2qm74 2164 2 contrast contrast NN cord-015021-pol2qm74 2164 3 , , , cord-015021-pol2qm74 2164 4 PGE PGE NNP cord-015021-pol2qm74 2164 5 greatly greatly RB cord-015021-pol2qm74 2164 6 promotes promote VBZ cord-015021-pol2qm74 2164 7 class class NN cord-015021-pol2qm74 2164 8 switching switch VBG cord-015021-pol2qm74 2164 9 to to IN cord-015021-pol2qm74 2164 10 IgE IgE NNP cord-015021-pol2qm74 2164 11 , , , cord-015021-pol2qm74 2164 12 the the DT cord-015021-pol2qm74 2164 13 isotype isotype NN cord-015021-pol2qm74 2164 14 responsible responsible JJ cord-015021-pol2qm74 2164 15 for for IN cord-015021-pol2qm74 2164 16 Type type NN cord-015021-pol2qm74 2164 17 I -PRON- PRP cord-015021-pol2qm74 2164 18 allergic allergic JJ cord-015021-pol2qm74 2164 19 hypersensitivity hypersensitivity NN cord-015021-pol2qm74 2164 20 . . . cord-015021-pol2qm74 2165 1 Thus thus RB cord-015021-pol2qm74 2165 2 , , , cord-015021-pol2qm74 2165 3 our -PRON- PRP$ cord-015021-pol2qm74 2165 4 model model NN cord-015021-pol2qm74 2165 5 mirrors mirror VBZ cord-015021-pol2qm74 2165 6 th~ th~ NNP cord-015021-pol2qm74 2165 7 general general JJ cord-015021-pol2qm74 2165 8 immunosuppression immunosuppression NNP cord-015021-pol2qm74 2165 9 and and CC cord-015021-pol2qm74 2165 10 elevated elevated JJ cord-015021-pol2qm74 2165 11 IgE IgE NNP cord-015021-pol2qm74 2165 12 titers titer NNS cord-015021-pol2qm74 2165 13 of of IN cord-015021-pol2qm74 2165 14 the the DT cord-015021-pol2qm74 2165 15 trauma trauma NN cord-015021-pol2qm74 2165 16 or or CC cord-015021-pol2qm74 2165 17 sepsis sepsis NN cord-015021-pol2qm74 2165 18 patient patient NN cord-015021-pol2qm74 2165 19 . . . cord-015021-pol2qm74 2166 1 PGE PGE NNP cord-015021-pol2qm74 2166 2 increases increase VBZ cord-015021-pol2qm74 2166 3 the the DT cord-015021-pol2qm74 2166 4 number number NN cord-015021-pol2qm74 2166 5 of of IN cord-015021-pol2qm74 2166 6 cells cell NNS cord-015021-pol2qm74 2166 7 secreting secrete VBG cord-015021-pol2qm74 2166 8 IgE IgE NNP cord-015021-pol2qm74 2166 9 and and CC cord-015021-pol2qm74 2166 10 IgGl IgGl NNP cord-015021-pol2qm74 2166 11 , , , cord-015021-pol2qm74 2166 12 acts act VBZ cord-015021-pol2qm74 2166 13 on on IN cord-015021-pol2qm74 2166 14 surface surface NN cord-015021-pol2qm74 2166 15 IgM IgM NNP cord-015021-pol2qm74 2166 16 positive positive JJ cord-015021-pol2qm74 2166 17 B B NNP cord-015021-pol2qm74 2166 18 cells cell NNS cord-015021-pol2qm74 2166 19 , , , cord-015021-pol2qm74 2166 20 synergizes synergize VBZ cord-015021-pol2qm74 2166 21 with with IN cord-015021-pol2qm74 2166 22 IL-4 IL-4 NNP cord-015021-pol2qm74 2166 23 and and CC cord-015021-pol2qm74 2166 24 LP$ LP$ NNP cord-015021-pol2qm74 2166 25 to to TO cord-015021-pol2qm74 2166 26 induce induce VB cord-015021-pol2qm74 2166 27 preswitch preswitch NN cord-015021-pol2qm74 2166 28 germline germline NN cord-015021-pol2qm74 2166 29 transcripts transcript NNS cord-015021-pol2qm74 2166 30 , , , cord-015021-pol2qm74 2166 31 and and CC cord-015021-pol2qm74 2166 32 induces induce VBZ cord-015021-pol2qm74 2166 33 more more RBR cord-015021-pol2qm74 2166 34 rapid rapid JJ cord-015021-pol2qm74 2166 35 expression expression NN cord-015021-pol2qm74 2166 36 of of IN cord-015021-pol2qm74 2166 37 mature mature JJ cord-015021-pol2qm74 2166 38 VDJ~ VDJ~ NNP cord-015021-pol2qm74 2166 39 mP mP . cord-015021-pol2qm74 2167 1 ~A ~A NFP cord-015021-pol2qm74 2167 2 than than IN cord-015021-pol2qm74 2167 3 in in IN cord-015021-pol2qm74 2167 4 eontro~ eontro~ NNP cord-015021-pol2qm74 2167 5 PGE PGE NNP cord-015021-pol2qm74 2167 6 intracellular intracellular JJ cord-015021-pol2qm74 2167 7 signalling signalling NN cord-015021-pol2qm74 2167 8 occurs occur VBZ cord-015021-pol2qm74 2167 9 through through IN cord-015021-pol2qm74 2167 10 cyclic cyclic JJ cord-015021-pol2qm74 2167 11 adenosine adenosine NN cord-015021-pol2qm74 2167 12 monophosphate monophosphate NN cord-015021-pol2qm74 2167 13 ( ( -LRB- cord-015021-pol2qm74 2167 14 cAMP camp NN cord-015021-pol2qm74 2167 15 ) ) -RRB- cord-015021-pol2qm74 2167 16 levels level NNS cord-015021-pol2qm74 2167 17 and and CC cord-015021-pol2qm74 2167 18 can can MD cord-015021-pol2qm74 2167 19 be be VB cord-015021-pol2qm74 2167 20 mimicked mimic VBN cord-015021-pol2qm74 2167 21 by by IN cord-015021-pol2qm74 2167 22 cAMP camp NN cord-015021-pol2qm74 2167 23 - - HYPH cord-015021-pol2qm74 2167 24 inducing induce VBG cord-015021-pol2qm74 2167 25 agents agent NNS cord-015021-pol2qm74 2167 26 and and CC cord-015021-pol2qm74 2167 27 blocl blocl NNS cord-015021-pol2qm74 2168 1 ~ed ~ed NNP cord-015021-pol2qm74 2168 2 by by IN cord-015021-pol2qm74 2168 3 an an DT cord-015021-pol2qm74 2168 4 inhibitor inhibitor NN cord-015021-pol2qm74 2168 5 of of IN cord-015021-pol2qm74 2168 6 cAMPdependent cAMPdependent NNP cord-015021-pol2qm74 2168 7 protein protein NN cord-015021-pol2qm74 2168 8 kinase kinase NN cord-015021-pol2qm74 2168 9 A. A. NNP cord-015021-pol2qm74 2168 10 PGE PGE NNP cord-015021-pol2qm74 2168 11 action action NN cord-015021-pol2qm74 2168 12 requires require VBZ cord-015021-pol2qm74 2169 1 de de NNP cord-015021-pol2qm74 2169 2 novo novo NNP cord-015021-pol2qm74 2169 3 protein protein NNP cord-015021-pol2qm74 2169 4 synthesis synthesis NN cord-015021-pol2qm74 2169 5 and and CC cord-015021-pol2qm74 2169 6 candidate candidate NN cord-015021-pol2qm74 2169 7 PGE PGE NNP cord-015021-pol2qm74 2169 8 - - HYPH cord-015021-pol2qm74 2169 9 inducible inducible JJ cord-015021-pol2qm74 2169 10 regulatory regulatory JJ cord-015021-pol2qm74 2169 11 proteins protein NNS cord-015021-pol2qm74 2169 12 have have VBP cord-015021-pol2qm74 2169 13 been be VBN cord-015021-pol2qm74 2169 14 identified identify VBN cord-015021-pol2qm74 2169 15 by by IN cord-015021-pol2qm74 2169 16 2D 2D NNP cord-015021-pol2qm74 2169 17 gel gel NNP cord-015021-pol2qm74 2169 18 eleetrophoresis eleetrophoresis NNP cord-015021-pol2qm74 2169 19 . . . cord-015021-pol2qm74 2170 1 Thus thus RB cord-015021-pol2qm74 2170 2 , , , cord-015021-pol2qm74 2170 3 PGE PGE NNP cord-015021-pol2qm74 2170 4 inhibits inhibit VBZ cord-015021-pol2qm74 2170 5 a a DT cord-015021-pol2qm74 2170 6 number number NN cord-015021-pol2qm74 2170 7 of of IN cord-015021-pol2qm74 2170 8 immune immune JJ cord-015021-pol2qm74 2170 9 mechanisms mechanism NNS cord-015021-pol2qm74 2170 10 while while IN cord-015021-pol2qm74 2170 11 promoting promote VBG cord-015021-pol2qm74 2170 12 IgE IgE NNP cord-015021-pol2qm74 2170 13 production production NN cord-015021-pol2qm74 2170 14 . . . cord-015021-pol2qm74 2171 1 A a DT cord-015021-pol2qm74 2171 2 deeper deep JJR cord-015021-pol2qm74 2171 3 understanding understanding NN cord-015021-pol2qm74 2171 4 of of IN cord-015021-pol2qm74 2171 5 PGE PGE NNP cord-015021-pol2qm74 2171 6 immune immune JJ cord-015021-pol2qm74 2171 7 regulation regulation NN cord-015021-pol2qm74 2171 8 may may MD cord-015021-pol2qm74 2171 9 lead lead VB cord-015021-pol2qm74 2171 10 to to IN cord-015021-pol2qm74 2171 11 more more RBR cord-015021-pol2qm74 2171 12 effective effective JJ cord-015021-pol2qm74 2171 13 treatment treatment NN cord-015021-pol2qm74 2171 14 of of IN cord-015021-pol2qm74 2171 15 immune immune JJ cord-015021-pol2qm74 2171 16 perturbations perturbation NNS cord-015021-pol2qm74 2171 17 as as IN cord-015021-pol2qm74 2171 18 sequelae sequela NNS cord-015021-pol2qm74 2171 19 of of IN cord-015021-pol2qm74 2171 20 trauma trauma NN cord-015021-pol2qm74 2171 21 , , , cord-015021-pol2qm74 2171 22 shock shock NN cord-015021-pol2qm74 2171 23 or or CC cord-015021-pol2qm74 2171 24 sepsis sepsis NN cord-015021-pol2qm74 2171 25 . . . cord-015021-pol2qm74 2172 1 During during IN cord-015021-pol2qm74 2172 2 infrarenai infrarenai JJ cord-015021-pol2qm74 2172 3 aortic aortic JJ cord-015021-pol2qm74 2172 4 surgery surgery NN cord-015021-pol2qm74 2172 5 mesetueric mesetueric NNP cord-015021-pol2qm74 2172 6 traction traction NN cord-015021-pol2qm74 2172 7 ( ( -LRB- cord-015021-pol2qm74 2172 8 re.t re.t CD cord-015021-pol2qm74 2172 9 . . . cord-015021-pol2qm74 2172 10 ) ) -RRB- cord-015021-pol2qm74 2173 1 results result NNS cord-015021-pol2qm74 2173 2 in in IN cord-015021-pol2qm74 2173 3 prostacyclin prostacyclin NNP cord-015021-pol2qm74 2173 4 ( ( -LRB- cord-015021-pol2qm74 2173 5 PGI PGI NNP cord-015021-pol2qm74 2173 6 : : : cord-015021-pol2qm74 2173 7 ) ) -RRB- cord-015021-pol2qm74 2174 1 release release VB cord-015021-pol2qm74 2174 2 and and CC cord-015021-pol2qm74 2174 3 consecutively consecutively RB cord-015021-pol2qm74 2174 4 in in IN cord-015021-pol2qm74 2174 5 hemodynamic hemodynamic JJ cord-015021-pol2qm74 2174 6 disturbances disturbance NNS cord-015021-pol2qm74 2174 7 ( ( -LRB- cord-015021-pol2qm74 2174 8 decreased decrease VBD cord-015021-pol2qm74 2174 9 systemic systemic JJ cord-015021-pol2qm74 2174 10 vascular vascular JJ cord-015021-pol2qm74 2174 11 resisteace resisteace NN cord-015021-pol2qm74 2174 12 , , , cord-015021-pol2qm74 2174 13 mean mean VB cord-015021-pol2qm74 2174 14 arterial arterial JJ cord-015021-pol2qm74 2174 15 pressure pressure NN cord-015021-pol2qm74 2174 16 ; ; , cord-015021-pol2qm74 2174 17 increased increase VBN cord-015021-pol2qm74 2174 18 cardiac cardiac JJ cord-015021-pol2qm74 2174 19 output output NN cord-015021-pol2qm74 2174 20 , , , cord-015021-pol2qm74 2174 21 heartrate heartrate NN cord-015021-pol2qm74 2174 22 ) ) -RRB- cord-015021-pol2qm74 2174 23 . . . cord-015021-pol2qm74 2175 1 These these DT cord-015021-pol2qm74 2175 2 symptomes symptome NNS cord-015021-pol2qm74 2175 3 are be VBP cord-015021-pol2qm74 2175 4 bypassed bypass VBN cord-015021-pol2qm74 2175 5 by by IN cord-015021-pol2qm74 2175 6 cyclooxygenase cyclooxygenase NN cord-015021-pol2qm74 2175 7 inhibition inhibition NN cord-015021-pol2qm74 2175 8 . . . cord-015021-pol2qm74 2176 1 Hemodynamic Hemodynamic NNP cord-015021-pol2qm74 2176 2 symptoms symptom NNS cord-015021-pol2qm74 2176 3 vanish vanish VBP cord-015021-pol2qm74 2176 4 after after IN cord-015021-pol2qm74 2176 5 30 30 CD cord-015021-pol2qm74 2176 6 - - SYM cord-015021-pol2qm74 2176 7 45 45 CD cord-015021-pol2qm74 2176 8 rain rain NN cord-015021-pol2qm74 2176 9 even even RB cord-015021-pol2qm74 2176 10 without without IN cord-015021-pol2qm74 2176 11 cyclooxygenase cyclooxygenase JJ cord-015021-pol2qm74 2176 12 inhibition inhibition NN cord-015021-pol2qm74 2176 13 although although IN cord-015021-pol2qm74 2176 14 PGI2 PGI2 NNP cord-015021-pol2qm74 2176 15 levels level NNS cord-015021-pol2qm74 2176 16 remain remain VBP cord-015021-pol2qm74 2176 17 elevated elevated JJ cord-015021-pol2qm74 2176 18 . . . cord-015021-pol2qm74 2177 1 To to TO cord-015021-pol2qm74 2177 2 study study VB cord-015021-pol2qm74 2177 3 the the DT cord-015021-pol2qm74 2177 4 endocrine endocrine JJ cord-015021-pol2qm74 2177 5 vasopressor vasopressor NN cord-015021-pol2qm74 2177 6 system system NN cord-015021-pol2qm74 2177 7 in in IN cord-015021-pol2qm74 2177 8 a a DT cord-015021-pol2qm74 2177 9 prospective prospective JJ cord-015021-pol2qm74 2177 10 double double JJ cord-015021-pol2qm74 2177 11 blinded blind VBN cord-015021-pol2qm74 2177 12 protocol protocol NN cord-015021-pol2qm74 2177 13 , , , cord-015021-pol2qm74 2177 14 we -PRON- PRP cord-015021-pol2qm74 2177 15 investigated investigate VBD cord-015021-pol2qm74 2177 16 26 26 CD cord-015021-pol2qm74 2177 17 patients patient NNS cord-015021-pol2qm74 2177 18 undergoing undergo VBG cord-015021-pol2qm74 2177 19 major major JJ cord-015021-pol2qm74 2177 20 abdominal abdominal JJ cord-015021-pol2qm74 2177 21 surgery surgery NN cord-015021-pol2qm74 2177 22 as as IN cord-015021-pol2qm74 2177 23 compared compare VBN cord-015021-pol2qm74 2177 24 to to IN cord-015021-pol2qm74 2177 25 26 26 CD cord-015021-pol2qm74 2177 26 ibuprofen ibuprofen NN cord-015021-pol2qm74 2177 27 ( ( -LRB- cord-015021-pol2qm74 2177 28 400 400 CD cord-015021-pol2qm74 2177 29 rag rag NN cord-015021-pol2qm74 2177 30 , , , cord-015021-pol2qm74 2177 31 i.v i.v NNP cord-015021-pol2qm74 2177 32 . . . cord-015021-pol2qm74 2177 33 ) ) -RRB- cord-015021-pol2qm74 2178 1 pretreated pretreate VBN cord-015021-pol2qm74 2178 2 ( ( -LRB- cord-015021-pol2qm74 2178 3 ibu ibu NNP cord-015021-pol2qm74 2178 4 ) ) -RRB- cord-015021-pol2qm74 2178 5 patients patient NNS cord-015021-pol2qm74 2178 6 . . . cord-015021-pol2qm74 2179 1 The the DT cord-015021-pol2qm74 2179 2 surgeon surgeon NN cord-015021-pol2qm74 2179 3 applied apply VBD cord-015021-pol2qm74 2179 4 m.t m.t NNP cord-015021-pol2qm74 2179 5 . . NNP cord-015021-pol2qm74 2179 6 in in IN cord-015021-pol2qm74 2179 7 a a DT cord-015021-pol2qm74 2179 8 uniform uniform JJ cord-015021-pol2qm74 2179 9 fashion fashion NN cord-015021-pol2qm74 2179 10 . . . cord-015021-pol2qm74 2180 1 We -PRON- PRP cord-015021-pol2qm74 2180 2 chose choose VBD cord-015021-pol2qm74 2180 3 a a DT cord-015021-pol2qm74 2180 4 general general JJ cord-015021-pol2qm74 2180 5 anesthesia anesthesia NN cord-015021-pol2qm74 2180 6 combined combine VBN cord-015021-pol2qm74 2180 7 with with IN cord-015021-pol2qm74 2180 8 a a DT cord-015021-pol2qm74 2180 9 supplemental supplemental JJ cord-015021-pol2qm74 2180 10 thoracic thoracic JJ cord-015021-pol2qm74 2180 11 epidural epidural NN cord-015021-pol2qm74 2180 12 anesthesia anesthesia NN cord-015021-pol2qm74 2180 13 . . . cord-015021-pol2qm74 2181 1 At at IN cord-015021-pol2qm74 2181 2 the the DT cord-015021-pol2qm74 2181 3 points point NNS cord-015021-pol2qm74 2181 4 in in IN cord-015021-pol2qm74 2181 5 time time NN cord-015021-pol2qm74 2181 6 5 5 CD cord-015021-pol2qm74 2181 7 , , , cord-015021-pol2qm74 2181 8 15 15 CD cord-015021-pol2qm74 2181 9 , , , cord-015021-pol2qm74 2181 10 30 30 CD cord-015021-pol2qm74 2181 11 , , , cord-015021-pol2qm74 2181 12 45 45 CD cord-015021-pol2qm74 2181 13 , , , cord-015021-pol2qm74 2181 14 90 90 CD cord-015021-pol2qm74 2181 15 , , , cord-015021-pol2qm74 2181 16 180 180 CD cord-015021-pol2qm74 2181 17 , , , cord-015021-pol2qm74 2181 18 360 360 CD cord-015021-pol2qm74 2181 19 , , , cord-015021-pol2qm74 2181 20 1440 1440 CD cord-015021-pol2qm74 2181 21 rain rain NN cord-015021-pol2qm74 2181 22 after after IN cord-015021-pol2qm74 2181 23 and and CC cord-015021-pol2qm74 2181 24 before before RB cord-015021-pol2qm74 2181 25 ( ( -LRB- cord-015021-pol2qm74 2181 26 to to IN cord-015021-pol2qm74 2181 27 ) ) -RRB- cord-015021-pol2qm74 2182 1 mesentzrie mesentzrie NNP cord-015021-pol2qm74 2182 2 traction traction NNP cord-015021-pol2qm74 2183 1 we -PRON- PRP cord-015021-pol2qm74 2183 2 determined determine VBD cord-015021-pol2qm74 2183 3 the the DT cord-015021-pol2qm74 2183 4 plasma plasma NN cord-015021-pol2qm74 2183 5 concentrations concentration NNS cord-015021-pol2qm74 2183 6 ( ( -LRB- cord-015021-pol2qm74 2183 7 pc pc NNP cord-015021-pol2qm74 2183 8 ) ) -RRB- cord-015021-pol2qm74 2183 9 of of IN cord-015021-pol2qm74 2183 10 6-keto 6-keto CD cord-015021-pol2qm74 2183 11 - - HYPH cord-015021-pol2qm74 2183 12 PGF PGF NNP cord-015021-pol2qm74 2184 1 ~o ~o NFP cord-015021-pol2qm74 2184 2 ~ ~ NFP cord-015021-pol2qm74 2184 3 pr~ pr~ XX cord-015021-pol2qm74 2184 4 , , , cord-015021-pol2qm74 2184 5 epinephrine epinephrine NN cord-015021-pol2qm74 2184 6 , , , cord-015021-pol2qm74 2184 7 norepinephrine norepinephrine NN cord-015021-pol2qm74 2184 8 , , , cord-015021-pol2qm74 2184 9 dopamine dopamine NN cord-015021-pol2qm74 2184 10 , , , cord-015021-pol2qm74 2184 11 renin renin NN cord-015021-pol2qm74 2184 12 , , , cord-015021-pol2qm74 2184 13 aldosterone aldosterone NN cord-015021-pol2qm74 2184 14 , , , cord-015021-pol2qm74 2184 15 ADH ADH NNP cord-015021-pol2qm74 2184 16 and and CC cord-015021-pol2qm74 2184 17 cortisol cortisol NN cord-015021-pol2qm74 2184 18 . . . cord-015021-pol2qm74 2185 1 Pc pc NN cord-015021-pol2qm74 2185 2 of of IN cord-015021-pol2qm74 2185 3 6-k 6-k CD cord-015021-pol2qm74 2185 4 - - HYPH cord-015021-pol2qm74 2185 5 PGF~,tp~ PGF~,tp~ NNPS cord-015021-pol2qm74 2185 6 , , , cord-015021-pol2qm74 2185 7 peaked peak VBD cord-015021-pol2qm74 2185 8 5 5 CD cord-015021-pol2qm74 2185 9 minutes minute NNS cord-015021-pol2qm74 2185 10 after after IN cord-015021-pol2qm74 2185 11 m.t m.t NNP cord-015021-pol2qm74 2185 12 . . . cord-015021-pol2qm74 2186 1 ( ( -LRB- cord-015021-pol2qm74 2186 2 2274_+284 2274_+284 CD cord-015021-pol2qm74 2186 3 , , , cord-015021-pol2qm74 2186 4 ibu ibu NNP cord-015021-pol2qm74 2186 5 : : : cord-015021-pol2qm74 2186 6 102_+12 102_+12 NNP cord-015021-pol2qm74 2186 7 , , , cord-015021-pol2qm74 2186 8 to to IN cord-015021-pol2qm74 2186 9 : : : cord-015021-pol2qm74 2186 10 60+I 60+i CD cord-015021-pol2qm74 2186 11 ng ng NNP cord-015021-pol2qm74 2186 12 / / SYM cord-015021-pol2qm74 2186 13 l l NN cord-015021-pol2qm74 2186 14 ) ) -RRB- cord-015021-pol2qm74 2186 15 and and CC cord-015021-pol2qm74 2186 16 declined decline VBD cord-015021-pol2qm74 2186 17 monotonously monotonously RB cord-015021-pol2qm74 2186 18 over over IN cord-015021-pol2qm74 2186 19 6 6 CD cord-015021-pol2qm74 2186 20 h h NN cord-015021-pol2qm74 2186 21 ( ( -LRB- cord-015021-pol2qm74 2186 22 203 203 CD cord-015021-pol2qm74 2186 23 + + CC cord-015021-pol2qm74 2186 24 _ _ NN cord-015021-pol2qm74 2186 25 42 42 CD cord-015021-pol2qm74 2186 26 , , , cord-015021-pol2qm74 2186 27 ibu ibu NNP cord-015021-pol2qm74 2186 28 : : : cord-015021-pol2qm74 2186 29 84_+ 84_+ CD cord-015021-pol2qm74 2186 30 12 12 CD cord-015021-pol2qm74 2186 31 ng/1 ng/1 NNS cord-015021-pol2qm74 2186 32 ) ) -RRB- cord-015021-pol2qm74 2186 33 . . . cord-015021-pol2qm74 2187 1 Catecholamine Catecholamine NNP cord-015021-pol2qm74 2187 2 pc pc NN cord-015021-pol2qm74 2187 3 " " '' cord-015021-pol2qm74 2187 4 s s NN cord-015021-pol2qm74 2187 5 did do VBD cord-015021-pol2qm74 2187 6 not not RB cord-015021-pol2qm74 2187 7 exceed exceed VB cord-015021-pol2qm74 2187 8 the the DT cord-015021-pol2qm74 2187 9 reference reference NN cord-015021-pol2qm74 2187 10 range range NN cord-015021-pol2qm74 2187 11 during during IN cord-015021-pol2qm74 2187 12 the the DT cord-015021-pol2qm74 2187 13 observation observation NN cord-015021-pol2qm74 2187 14 period period NN cord-015021-pol2qm74 2187 15 . . . cord-015021-pol2qm74 2188 1 Reninpc Reninpc NNP cord-015021-pol2qm74 2188 2 peaked peak VBD cord-015021-pol2qm74 2188 3 after after IN cord-015021-pol2qm74 2188 4 45 45 CD cord-015021-pol2qm74 2188 5 rain rain NN cord-015021-pol2qm74 2188 6 ( ( -LRB- cord-015021-pol2qm74 2188 7 66_+23 66_+23 CD cord-015021-pol2qm74 2188 8 , , , cord-015021-pol2qm74 2188 9 ibu ibu NN cord-015021-pol2qm74 2188 10 : : : cord-015021-pol2qm74 2189 1 18 18 CD cord-015021-pol2qm74 2189 2 + + SYM cord-015021-pol2qm74 2189 3 3 3 CD cord-015021-pol2qm74 2189 4 , , , cord-015021-pol2qm74 2189 5 to to IN cord-015021-pol2qm74 2189 6 : : : cord-015021-pol2qm74 2189 7 16-+2/~U 16-+2/~u LS cord-015021-pol2qm74 2189 8 / / SYM cord-015021-pol2qm74 2189 9 ml ml NN cord-015021-pol2qm74 2189 10 ) ) -RRB- cord-015021-pol2qm74 2189 11 ; ; : cord-015021-pol2qm74 2189 12 aldosteronc aldosteronc NNP cord-015021-pol2qm74 2189 13 also also RB cord-015021-pol2qm74 2189 14 presented present VBD cord-015021-pol2qm74 2189 15 a a DT cord-015021-pol2qm74 2189 16 maximum maximum NN cord-015021-pol2qm74 2189 17 after after IN cord-015021-pol2qm74 2189 18 45 45 CD cord-015021-pol2qm74 2189 19 rain rain NN cord-015021-pol2qm74 2189 20 ( ( -LRB- cord-015021-pol2qm74 2189 21 110 110 CD cord-015021-pol2qm74 2189 22 + + SYM cord-015021-pol2qm74 2189 23 12 12 CD cord-015021-pol2qm74 2189 24 , , , cord-015021-pol2qm74 2189 25 ibu ibu NNP cord-015021-pol2qm74 2189 26 : : : cord-015021-pol2qm74 2189 27 66-+ 66-+ CD cord-015021-pol2qm74 2189 28 15 15 CD cord-015021-pol2qm74 2189 29 , , , cord-015021-pol2qm74 2189 30 to to IN cord-015021-pol2qm74 2189 31 : : : cord-015021-pol2qm74 2189 32 56 56 CD cord-015021-pol2qm74 2189 33 + + SYM cord-015021-pol2qm74 2189 34 -7 -7 CD cord-015021-pol2qm74 2189 35 pg pg NNP cord-015021-pol2qm74 2189 36 / / SYM cord-015021-pol2qm74 2189 37 ml ml NNP cord-015021-pol2qm74 2189 38 ) ) -RRB- cord-015021-pol2qm74 2189 39 , , , cord-015021-pol2qm74 2189 40 whereas whereas IN cord-015021-pol2qm74 2189 41 cortisol cortisol NN cord-015021-pol2qm74 2189 42 demonstrated demonstrate VBD cord-015021-pol2qm74 2189 43 irrespectively irrespectively RB cord-015021-pol2qm74 2189 44 of of IN cord-015021-pol2qm74 2189 45 circadian circadian NN cord-015021-pol2qm74 2189 46 rhythms rhythm VBZ cord-015021-pol2qm74 2189 47 a a DT cord-015021-pol2qm74 2189 48 maximum maximum JJ cord-015021-pol2qm74 2189 49 6 6 CD cord-015021-pol2qm74 2189 50 h h NN cord-015021-pol2qm74 2189 51 after after IN cord-015021-pol2qm74 2189 52 m.t m.t NNP cord-015021-pol2qm74 2189 53 . . . cord-015021-pol2qm74 2190 1 ( ( -LRB- cord-015021-pol2qm74 2190 2 26+_1 26+_1 CD cord-015021-pol2qm74 2190 3 , , , cord-015021-pol2qm74 2190 4 ibu ibu NNP cord-015021-pol2qm74 2190 5 : : : cord-015021-pol2qm74 2190 6 24-+3 24-+3 CD cord-015021-pol2qm74 2190 7 , , , cord-015021-pol2qm74 2190 8 to to IN cord-015021-pol2qm74 2190 9 : : : cord-015021-pol2qm74 2190 10 10+_1 10+_1 CD cord-015021-pol2qm74 2190 11 ~g/1 ~g/1 NFP cord-015021-pol2qm74 2190 12 ) ) -RRB- cord-015021-pol2qm74 2190 13 . . . cord-015021-pol2qm74 2191 1 ADH ADH NNP cord-015021-pol2qm74 2191 2 pc pc NN cord-015021-pol2qm74 2191 3 peaked peak VBD cord-015021-pol2qm74 2191 4 5 5 CD cord-015021-pol2qm74 2191 5 min min NN cord-015021-pol2qm74 2191 6 after after IN cord-015021-pol2qm74 2191 7 m.t m.t NNP cord-015021-pol2qm74 2191 8 . . . cord-015021-pol2qm74 2192 1 ( ( -LRB- cord-015021-pol2qm74 2192 2 71 71 CD cord-015021-pol2qm74 2192 3 + + SYM cord-015021-pol2qm74 2192 4 7 7 CD cord-015021-pol2qm74 2192 5 , , , cord-015021-pol2qm74 2192 6 ibu ibu NNP cord-015021-pol2qm74 2192 7 : : : cord-015021-pol2qm74 2193 1 20-+6 20-+6 CD cord-015021-pol2qm74 2193 2 , , , cord-015021-pol2qm74 2193 3 to to IN cord-015021-pol2qm74 2193 4 : : : cord-015021-pol2qm74 2193 5 5+_1 5+_1 CD cord-015021-pol2qm74 2193 6 pg pg NNP cord-015021-pol2qm74 2193 7 / / SYM cord-015021-pol2qm74 2193 8 ml ml NNP cord-015021-pol2qm74 2193 9 ) ) -RRB- cord-015021-pol2qm74 2193 10 and and CC cord-015021-pol2qm74 2193 11 showed show VBD cord-015021-pol2qm74 2193 12 analogously analogously RB cord-015021-pol2qm74 2193 13 to to IN cord-015021-pol2qm74 2193 14 6-k 6-k CD cord-015021-pol2qm74 2193 15 - - HYPH cord-015021-pol2qm74 2193 16 PGFt PGFt NNS cord-015021-pol2qm74 2193 17 ~ ~ NFP cord-015021-pol2qm74 2193 18 j~ j~ UH cord-015021-pol2qm74 2193 19 pc pc VB cord-015021-pol2qm74 2193 20 a a DT cord-015021-pol2qm74 2193 21 monotone monotone JJ cord-015021-pol2qm74 2193 22 decline decline NN cord-015021-pol2qm74 2193 23 over over IN cord-015021-pol2qm74 2193 24 the the DT cord-015021-pol2qm74 2193 25 observation observation NN cord-015021-pol2qm74 2193 26 period period NN cord-015021-pol2qm74 2193 27 . . . cord-015021-pol2qm74 2194 1 Our -PRON- PRP$ cord-015021-pol2qm74 2194 2 data datum NNS cord-015021-pol2qm74 2194 3 demonstrate demonstrate VBP cord-015021-pol2qm74 2194 4 a a DT cord-015021-pol2qm74 2194 5 counteractive counteractive JJ cord-015021-pol2qm74 2194 6 reaction reaction NN cord-015021-pol2qm74 2194 7 to to IN cord-015021-pol2qm74 2194 8 PGIz PGIz NNS cord-015021-pol2qm74 2194 9 mediated mediate VBN cord-015021-pol2qm74 2194 10 vasodilation vasodilation NN cord-015021-pol2qm74 2194 11 via via IN cord-015021-pol2qm74 2194 12 ADH ADH NNP cord-015021-pol2qm74 2194 13 secretion secretion NN cord-015021-pol2qm74 2194 14 . . . cord-015021-pol2qm74 2195 1 The the DT cord-015021-pol2qm74 2195 2 second second JJ cord-015021-pol2qm74 2195 3 regulative regulative NN cord-015021-pol2qm74 2195 4 is be VBZ cord-015021-pol2qm74 2195 5 the the DT cord-015021-pol2qm74 2195 6 renin renin NN cord-015021-pol2qm74 2195 7 - - HYPH cord-015021-pol2qm74 2195 8 angiotensin angiotensin NN cord-015021-pol2qm74 2195 9 - - HYPH cord-015021-pol2qm74 2195 10 aldosterone aldosterone NN cord-015021-pol2qm74 2195 11 system system NN cord-015021-pol2qm74 2195 12 ( ( -LRB- cord-015021-pol2qm74 2195 13 RAAS RAAS NNP cord-015021-pol2qm74 2195 14 ) ) -RRB- cord-015021-pol2qm74 2195 15 , , , cord-015021-pol2qm74 2195 16 which which WDT cord-015021-pol2qm74 2195 17 is be VBZ cord-015021-pol2qm74 2195 18 activated activate VBN cord-015021-pol2qm74 2195 19 45 45 CD cord-015021-pol2qm74 2195 20 min min NN cord-015021-pol2qm74 2195 21 after after IN cord-015021-pol2qm74 2195 22 m.t m.t NNP cord-015021-pol2qm74 2195 23 . . NNP cord-015021-pol2qm74 2195 24 , , , cord-015021-pol2qm74 2195 25 the the DT cord-015021-pol2qm74 2195 26 aldosterone aldosterone NN cord-015021-pol2qm74 2195 27 pc pc NN cord-015021-pol2qm74 2195 28 does do VBZ cord-015021-pol2qm74 2195 29 not not RB cord-015021-pol2qm74 2195 30 paratlel paratlel VBZ cord-015021-pol2qm74 2195 31 the the DT cord-015021-pol2qm74 2195 32 cortisol cortisol NN cord-015021-pol2qm74 2195 33 pc pc NN cord-015021-pol2qm74 2195 34 , , , cord-015021-pol2qm74 2195 35 which which WDT cord-015021-pol2qm74 2195 36 peaked peak VBD cord-015021-pol2qm74 2195 37 post post NN cord-015021-pol2qm74 2195 38 operafionem operafionem NN cord-015021-pol2qm74 2195 39 in in IN cord-015021-pol2qm74 2195 40 both both DT cord-015021-pol2qm74 2195 41 groups group NNS cord-015021-pol2qm74 2195 42 , , , cord-015021-pol2qm74 2195 43 probably probably RB cord-015021-pol2qm74 2195 44 due due IN cord-015021-pol2qm74 2195 45 to to IN cord-015021-pol2qm74 2195 46 the the DT cord-015021-pol2qm74 2195 47 end end NN cord-015021-pol2qm74 2195 48 of of IN cord-015021-pol2qm74 2195 49 anaesthesia anaesthesia NN cord-015021-pol2qm74 2195 50 . . . cord-015021-pol2qm74 2196 1 A a DT cord-015021-pol2qm74 2196 2 regulative regulative JJ cord-015021-pol2qm74 2196 3 release release NN cord-015021-pol2qm74 2196 4 of of IN cord-015021-pol2qm74 2196 5 catecholamines catecholamine NNS cord-015021-pol2qm74 2196 6 could could MD cord-015021-pol2qm74 2196 7 not not RB cord-015021-pol2qm74 2196 8 be be VB cord-015021-pol2qm74 2196 9 documented document VBN cord-015021-pol2qm74 2196 10 . . . cord-015021-pol2qm74 2197 1 The the DT cord-015021-pol2qm74 2197 2 activation activation NN cord-015021-pol2qm74 2197 3 of of IN cord-015021-pol2qm74 2197 4 ADH ADH NNP cord-015021-pol2qm74 2197 5 and and CC cord-015021-pol2qm74 2197 6 RAAS RAAS NNP cord-015021-pol2qm74 2197 7 after after IN cord-015021-pol2qm74 2197 8 MT MT NNP cord-015021-pol2qm74 2197 9 is be VBZ cord-015021-pol2qm74 2197 10 not not RB cord-015021-pol2qm74 2197 11 a a DT cord-015021-pol2qm74 2197 12 hormonal hormonal JJ cord-015021-pol2qm74 2197 13 response response NN cord-015021-pol2qm74 2197 14 primaryly primaryly NN cord-015021-pol2qm74 2197 15 related relate VBN cord-015021-pol2qm74 2197 16 to to IN cord-015021-pol2qm74 2197 17 surgical surgical JJ cord-015021-pol2qm74 2197 18 trauma trauma NN cord-015021-pol2qm74 2197 19 and/or and/or CC cord-015021-pol2qm74 2197 20 stress stress NN cord-015021-pol2qm74 2197 21 but but CC cord-015021-pol2qm74 2197 22 a a DT cord-015021-pol2qm74 2197 23 counterregulation counterregulation NN cord-015021-pol2qm74 2197 24 to to IN cord-015021-pol2qm74 2197 25 systemic systemic JJ cord-015021-pol2qm74 2197 26 vasoditafion vasoditafion NN cord-015021-pol2qm74 2197 27 induced induce VBN cord-015021-pol2qm74 2197 28 by by IN cord-015021-pol2qm74 2197 29 prostacyclin prostacyclin NNP cord-015021-pol2qm74 2197 30 . . . cord-015021-pol2qm74 2198 1 Although although IN cord-015021-pol2qm74 2198 2 ADH ADH NNP cord-015021-pol2qm74 2198 3 and and CC cord-015021-pol2qm74 2198 4 RAAS RAAS NNP cord-015021-pol2qm74 2198 5 support support VBP cord-015021-pol2qm74 2198 6 systemic systemic JJ cord-015021-pol2qm74 2198 7 circulation circulation NN cord-015021-pol2qm74 2198 8 , , , cord-015021-pol2qm74 2198 9 angiotensin angiotensin NN cord-015021-pol2qm74 2198 10 and and CC cord-015021-pol2qm74 2198 11 vasopressin vasopressin NN cord-015021-pol2qm74 2198 12 may may MD cord-015021-pol2qm74 2198 13 compromise compromise VB cord-015021-pol2qm74 2198 14 local local JJ cord-015021-pol2qm74 2198 15 organ organ NN cord-015021-pol2qm74 2198 16 blood blood NN cord-015021-pol2qm74 2198 17 flow flow NN cord-015021-pol2qm74 2198 18 ( ( -LRB- cord-015021-pol2qm74 2199 1 e.g. e.g. IN cord-015021-pol2qm74 2199 2 splancimic splancimic JJ cord-015021-pol2qm74 2199 3 vascular vascular JJ cord-015021-pol2qm74 2199 4 bed bed NN cord-015021-pol2qm74 2199 5 ) ) -RRB- cord-015021-pol2qm74 2199 6 . . . cord-015021-pol2qm74 2200 1 Insfitut Insfitut NNP cord-015021-pol2qm74 2200 2 f. f. NN cord-015021-pol2qm74 2200 3 Klin Klin NNP cord-015021-pol2qm74 2200 4 . . . cord-015021-pol2qm74 2201 1 Chemic Chemic NNP cord-015021-pol2qm74 2201 2 , , , cord-015021-pol2qm74 2201 3 Anaesthesiologie Anaesthesiologie NNP cord-015021-pol2qm74 2201 4 ~ ~ NFP cord-015021-pol2qm74 2201 5 , , , cord-015021-pol2qm74 2201 6 Chirurgie Chirurgie NNP cord-015021-pol2qm74 2201 7 l l NNP cord-015021-pol2qm74 2201 8 * * NFP cord-015021-pol2qm74 2201 9 , , , cord-015021-pol2qm74 2201 10 Univ Univ NNP cord-015021-pol2qm74 2201 11 . . . cord-015021-pol2qm74 2202 1 Ulm Ulm NNP cord-015021-pol2qm74 2202 2 , , , cord-015021-pol2qm74 2202 3 89070 89070 CD cord-015021-pol2qm74 2202 4 Elm Elm NNP cord-015021-pol2qm74 2202 5 , , , cord-015021-pol2qm74 2202 6 Expression expression NN cord-015021-pol2qm74 2202 7 of of IN cord-015021-pol2qm74 2202 8 c c NNP cord-015021-pol2qm74 2202 9 - - HYPH cord-015021-pol2qm74 2202 10 fos fos NNP cord-015021-pol2qm74 2202 11 protein protein NN cord-015021-pol2qm74 2202 12 in in IN cord-015021-pol2qm74 2202 13 rat rat NN cord-015021-pol2qm74 2202 14 brain brain NN cord-015021-pol2qm74 2202 15 following follow VBG cord-015021-pol2qm74 2202 16 occlusion occlusion NN cord-015021-pol2qm74 2202 17 of of IN cord-015021-pol2qm74 2202 18 superior superior JJ cord-015021-pol2qm74 2202 19 mesenterie mesenterie NNP cord-015021-pol2qm74 2202 20 artery artery NN cord-015021-pol2qm74 2202 21 . . . cord-015021-pol2qm74 2203 1 Takanobu Takanobu NNP cord-015021-pol2qm74 2203 2 There there EX cord-015021-pol2qm74 2203 3 is be VBZ cord-015021-pol2qm74 2203 4 general general JJ cord-015021-pol2qm74 2203 5 agreement agreement NN cord-015021-pol2qm74 2203 6 that that WDT cord-015021-pol2qm74 2203 7 neurologic neurologic JJ cord-015021-pol2qm74 2203 8 abnormalities abnormality NNS cord-015021-pol2qm74 2203 9 are be VBP cord-015021-pol2qm74 2203 10 seen see VBN cord-015021-pol2qm74 2203 11 in in IN cord-015021-pol2qm74 2203 12 sepsis sepsis NN cord-015021-pol2qm74 2203 13 . . . cord-015021-pol2qm74 2204 1 The the DT cord-015021-pol2qm74 2204 2 aim aim NN cord-015021-pol2qm74 2204 3 of of IN cord-015021-pol2qm74 2204 4 this this DT cord-015021-pol2qm74 2204 5 study study NN cord-015021-pol2qm74 2204 6 is be VBZ cord-015021-pol2qm74 2204 7 to to TO cord-015021-pol2qm74 2204 8 examine examine VB cord-015021-pol2qm74 2204 9 what what WDT cord-015021-pol2qm74 2204 10 effect effect NN cord-015021-pol2qm74 2204 11 does do VBZ cord-015021-pol2qm74 2204 12 the the DT cord-015021-pol2qm74 2204 13 brain brain NN cord-015021-pol2qm74 2204 14 receive receive VB cord-015021-pol2qm74 2204 15 in in IN cord-015021-pol2qm74 2204 16 case case NN cord-015021-pol2qm74 2204 17 of of IN cord-015021-pol2qm74 2204 18 SMA SMA NNP cord-015021-pol2qm74 2204 19 occlusion occlusion NN cord-015021-pol2qm74 2204 20 by by IN cord-015021-pol2qm74 2204 21 immunohistochemistry immunohistochemistry NN cord-015021-pol2qm74 2204 22 using use VBG cord-015021-pol2qm74 2204 23 antibody antibody NN cord-015021-pol2qm74 2204 24 to to IN cord-015021-pol2qm74 2204 25 c c NNP cord-015021-pol2qm74 2204 26 - - HYPH cord-015021-pol2qm74 2204 27 fos fos NNP cord-015021-pol2qm74 2204 28 , , , cord-015021-pol2qm74 2204 29 an an DT cord-015021-pol2qm74 2204 30 immediate immediate JJ cord-015021-pol2qm74 2204 31 early early JJ cord-015021-pol2qm74 2204 32 gene gene NN cord-015021-pol2qm74 2204 33 , , , cord-015021-pol2qm74 2204 34 which which WDT cord-015021-pol2qm74 2204 35 is be VBZ cord-015021-pol2qm74 2204 36 recently recently RB cord-015021-pol2qm74 2204 37 recognized recognize VBN cord-015021-pol2qm74 2204 38 as as IN cord-015021-pol2qm74 2204 39 a a DT cord-015021-pol2qm74 2204 40 genetic genetic JJ cord-015021-pol2qm74 2204 41 marker marker NN cord-015021-pol2qm74 2204 42 of of IN cord-015021-pol2qm74 2204 43 activated activate VBN cord-015021-pol2qm74 2204 44 neurons neuron NNS cord-015021-pol2qm74 2204 45 . . . cord-015021-pol2qm74 2205 1 Moreover moreover RB cord-015021-pol2qm74 2205 2 , , , cord-015021-pol2qm74 2205 3 we -PRON- PRP cord-015021-pol2qm74 2205 4 investigated investigate VBD cord-015021-pol2qm74 2205 5 the the DT cord-015021-pol2qm74 2205 6 correlation correlation NN cord-015021-pol2qm74 2205 7 between between IN cord-015021-pol2qm74 2205 8 c c NNP cord-015021-pol2qm74 2205 9 - - HYPH cord-015021-pol2qm74 2205 10 fos fos NNP cord-015021-pol2qm74 2205 11 induction induction NN cord-015021-pol2qm74 2205 12 in in IN cord-015021-pol2qm74 2205 13 the the DT cord-015021-pol2qm74 2205 14 brain brain NN cord-015021-pol2qm74 2205 15 and and CC cord-015021-pol2qm74 2205 16 plasma plasma NN cord-015021-pol2qm74 2205 17 endotoxiu endotoxiu JJ cord-015021-pol2qm74 2205 18 level level NN cord-015021-pol2qm74 2205 19 . . . cord-015021-pol2qm74 2206 1 20 20 CD cord-015021-pol2qm74 2206 2 rats rat NNS cord-015021-pol2qm74 2206 3 of of IN cord-015021-pol2qm74 2206 4 them -PRON- PRP cord-015021-pol2qm74 2206 5 received receive VBD cord-015021-pol2qm74 2206 6 SMA SMA NNP cord-015021-pol2qm74 2206 7 clipping clip VBG cord-015021-pol2qm74 2206 8 and and CC cord-015021-pol2qm74 2206 9 others other NNS cord-015021-pol2qm74 2206 10 wee wee VBP cord-015021-pol2qm74 2206 11 used use VBN cord-015021-pol2qm74 2206 12 as as IN cord-015021-pol2qm74 2206 13 control control NN cord-015021-pol2qm74 2206 14 . . . cord-015021-pol2qm74 2207 1 Control control NN cord-015021-pol2qm74 2207 2 and and CC cord-015021-pol2qm74 2207 3 treated treat VBD cord-015021-pol2qm74 2207 4 rats rat NNS cord-015021-pol2qm74 2207 5 at at IN cord-015021-pol2qm74 2207 6 2 2 CD cord-015021-pol2qm74 2207 7 , , , cord-015021-pol2qm74 2207 8 4 4 CD cord-015021-pol2qm74 2207 9 , , , cord-015021-pol2qm74 2207 10 6 6 CD cord-015021-pol2qm74 2207 11 , , , cord-015021-pol2qm74 2207 12 8 8 CD cord-015021-pol2qm74 2207 13 hours hour NNS cord-015021-pol2qm74 2207 14 were be VBD cord-015021-pol2qm74 2207 15 perfused perfuse VBN cord-015021-pol2qm74 2207 16 and and CC cord-015021-pol2qm74 2207 17 fixed fix VBN cord-015021-pol2qm74 2207 18 . . . cord-015021-pol2qm74 2208 1 The the DT cord-015021-pol2qm74 2208 2 brain brain NN cord-015021-pol2qm74 2208 3 were be VBD cord-015021-pol2qm74 2208 4 sectioned section VBN cord-015021-pol2qm74 2208 5 at at IN cord-015021-pol2qm74 2208 6 20 20 CD cord-015021-pol2qm74 2208 7 pm pm NN cord-015021-pol2qm74 2208 8 and and CC cord-015021-pol2qm74 2208 9 stained stain VBN cord-015021-pol2qm74 2208 10 by by IN cord-015021-pol2qm74 2208 11 ABC ABC NNP cord-015021-pol2qm74 2208 12 method method NN cord-015021-pol2qm74 2208 13 using use VBG cord-015021-pol2qm74 2208 14 c c NN cord-015021-pol2qm74 2208 15 - - HYPH cord-015021-pol2qm74 2208 16 fos fos NNP cord-015021-pol2qm74 2208 17 antibody antibody NN cord-015021-pol2qm74 2208 18 . . . cord-015021-pol2qm74 2209 1 Plasma plasma NN cord-015021-pol2qm74 2209 2 endotoxin endotoxin NN cord-015021-pol2qm74 2209 3 level level NN cord-015021-pol2qm74 2209 4 of of IN cord-015021-pol2qm74 2209 5 5 5 CD cord-015021-pol2qm74 2209 6 rats rat NNS cord-015021-pol2qm74 2209 7 were be VBD cord-015021-pol2qm74 2209 8 measured measure VBN cord-015021-pol2qm74 2209 9 at at IN cord-015021-pol2qm74 2209 10 0 0 CD cord-015021-pol2qm74 2209 11 , , , cord-015021-pol2qm74 2209 12 2 2 CD cord-015021-pol2qm74 2209 13 , , , cord-015021-pol2qm74 2209 14 4 4 CD cord-015021-pol2qm74 2209 15 , , , cord-015021-pol2qm74 2209 16 6 6 CD cord-015021-pol2qm74 2209 17 , , , cord-015021-pol2qm74 2209 18 8 8 CD cord-015021-pol2qm74 2209 19 hours hour NNS cord-015021-pol2qm74 2209 20 after after IN cord-015021-pol2qm74 2209 21 the the DT cord-015021-pol2qm74 2209 22 treatment treatment NN cord-015021-pol2qm74 2209 23 by by IN cord-015021-pol2qm74 2209 24 chromogenic chromogenic NNP cord-015021-pol2qm74 2209 25 limulus limulus NNP cord-015021-pol2qm74 2209 26 method method NN cord-015021-pol2qm74 2209 27 . . . cord-015021-pol2qm74 2210 1 Immunohistochemical Immunohistochemical NNP cord-015021-pol2qm74 2210 2 study study NN cord-015021-pol2qm74 2210 3 showed show VBD cord-015021-pol2qm74 2210 4 scarcely scarcely RB cord-015021-pol2qm74 2210 5 no no DT cord-015021-pol2qm74 2210 6 immunoreactivity immunoreactivity NN cord-015021-pol2qm74 2210 7 in in IN cord-015021-pol2qm74 2210 8 control control NN cord-015021-pol2qm74 2210 9 rat rat NN cord-015021-pol2qm74 2210 10 brain brain NN cord-015021-pol2qm74 2210 11 . . . cord-015021-pol2qm74 2211 1 In in IN cord-015021-pol2qm74 2211 2 treated treated JJ cord-015021-pol2qm74 2211 3 rat rat NN cord-015021-pol2qm74 2211 4 brain brain NN cord-015021-pol2qm74 2211 5 , , , cord-015021-pol2qm74 2211 6 the the DT cord-015021-pol2qm74 2211 7 significant significant JJ cord-015021-pol2qm74 2211 8 expression expression NN cord-015021-pol2qm74 2211 9 of of IN cord-015021-pol2qm74 2211 10 c c NNP cord-015021-pol2qm74 2211 11 - - : cord-015021-pol2qm74 2211 12 los los NNP cord-015021-pol2qm74 2211 13 was be VBD cord-015021-pol2qm74 2211 14 detected detect VBN cord-015021-pol2qm74 2211 15 in in IN cord-015021-pol2qm74 2211 16 specific specific JJ cord-015021-pol2qm74 2211 17 nuclei nucleus NNS cord-015021-pol2qm74 2211 18 including include VBG cord-015021-pol2qm74 2211 19 the the DT cord-015021-pol2qm74 2211 20 habenula habenula NN cord-015021-pol2qm74 2211 21 , , , cord-015021-pol2qm74 2211 22 some some DT cord-015021-pol2qm74 2211 23 hypothalamie hypothalamie NNP cord-015021-pol2qm74 2211 24 nuclei nucleus NNS cord-015021-pol2qm74 2211 25 , , , cord-015021-pol2qm74 2211 26 amygdala amygdala NN cord-015021-pol2qm74 2211 27 , , , cord-015021-pol2qm74 2211 28 locus locus NN cord-015021-pol2qm74 2211 29 ceruleus ceruleu NNS cord-015021-pol2qm74 2211 30 and and CC cord-015021-pol2qm74 2211 31 nucleus nucleus NN cord-015021-pol2qm74 2211 32 tractus tractus NNP cord-015021-pol2qm74 2211 33 solitarii solitarii NNP cord-015021-pol2qm74 2211 34 . . . cord-015021-pol2qm74 2212 1 Such such JJ cord-015021-pol2qm74 2212 2 immunoreactivities immunoreactivitie NNS cord-015021-pol2qm74 2212 3 were be VBD cord-015021-pol2qm74 2212 4 increased increase VBN cord-015021-pol2qm74 2212 5 in in IN cord-015021-pol2qm74 2212 6 time time NN cord-015021-pol2qm74 2212 7 curse curse NN cord-015021-pol2qm74 2212 8 , , , cord-015021-pol2qm74 2212 9 which which WDT cord-015021-pol2qm74 2212 10 well well RB cord-015021-pol2qm74 2212 11 corresponded correspond VBD cord-015021-pol2qm74 2212 12 plasma plasma NN cord-015021-pol2qm74 2212 13 endotoxin endotoxin NN cord-015021-pol2qm74 2212 14 levels level NNS cord-015021-pol2qm74 2212 15 . . . cord-015021-pol2qm74 2213 1 The the DT cord-015021-pol2qm74 2213 2 mean mean JJ cord-015021-pol2qm74 2213 3 plasma plasma NN cord-015021-pol2qm74 2213 4 endotoxin endotoxin NN cord-015021-pol2qm74 2213 5 level level NN cord-015021-pol2qm74 2213 6 of of IN cord-015021-pol2qm74 2213 7 0 0 CD cord-015021-pol2qm74 2213 8 , , , cord-015021-pol2qm74 2213 9 2,4 2,4 CD cord-015021-pol2qm74 2213 10 , , , cord-015021-pol2qm74 2213 11 6 6 CD cord-015021-pol2qm74 2213 12 , , , cord-015021-pol2qm74 2213 13 8 8 CD cord-015021-pol2qm74 2213 14 hours hour NNS cord-015021-pol2qm74 2213 15 after after IN cord-015021-pol2qm74 2213 16 the the DT cord-015021-pol2qm74 2213 17 treatment treatment NN cord-015021-pol2qm74 2213 18 were be VBD cord-015021-pol2qm74 2213 19 6.48 6.48 CD cord-015021-pol2qm74 2213 20 ± ± CD cord-015021-pol2qm74 2213 21 5.57 5.57 CD cord-015021-pol2qm74 2213 22 , , , cord-015021-pol2qm74 2213 23 15.0 15.0 CD cord-015021-pol2qm74 2213 24 _ _ NN cord-015021-pol2qm74 2213 25 -4 -4 NNP cord-015021-pol2qm74 2213 26 - - HYPH cord-015021-pol2qm74 2213 27 4.37 4.37 CD cord-015021-pol2qm74 2213 28 , , , cord-015021-pol2qm74 2213 29 10.0 10.0 CD cord-015021-pol2qm74 2213 30 _ _ NN cord-015021-pol2qm74 2213 31 + + SYM cord-015021-pol2qm74 2213 32 4.18 4.18 CD cord-015021-pol2qm74 2213 33 , , , cord-015021-pol2qm74 2213 34 14.4 14.4 CD cord-015021-pol2qm74 2213 35 ± ± CD cord-015021-pol2qm74 2213 36 3.52 3.52 CD cord-015021-pol2qm74 2213 37 and and CC cord-015021-pol2qm74 2213 38 58.4 58.4 CD cord-015021-pol2qm74 2213 39 ± ± CD cord-015021-pol2qm74 2213 40 28 28 CD cord-015021-pol2qm74 2213 41 .6 .6 CD cord-015021-pol2qm74 2213 42 pg pg NNP cord-015021-pol2qm74 2213 43 / / SYM cord-015021-pol2qm74 2213 44 ml ml NNS cord-015021-pol2qm74 2213 45 , , , cord-015021-pol2qm74 2213 46 respectively respectively RB cord-015021-pol2qm74 2213 47 . . . cord-015021-pol2qm74 2214 1 The the DT cord-015021-pol2qm74 2214 2 results result NNS cord-015021-pol2qm74 2214 3 indicate indicate VBP cord-015021-pol2qm74 2214 4 that that IN cord-015021-pol2qm74 2214 5 limbic limbic JJ cord-015021-pol2qm74 2214 6 and and CC cord-015021-pol2qm74 2214 7 hypothalamic hypothalamic JJ cord-015021-pol2qm74 2214 8 - - HYPH cord-015021-pol2qm74 2214 9 brainstem brainstem NN cord-015021-pol2qm74 2214 10 systems system NNS cord-015021-pol2qm74 2214 11 are be VBP cord-015021-pol2qm74 2214 12 involved involve VBN cord-015021-pol2qm74 2214 13 in in IN cord-015021-pol2qm74 2214 14 SMA SMA NNP cord-015021-pol2qm74 2214 15 occlusion occlusion NN cord-015021-pol2qm74 2214 16 , , , cord-015021-pol2qm74 2214 17 and and CC cord-015021-pol2qm74 2214 18 suggest suggest VBP cord-015021-pol2qm74 2214 19 that that IN cord-015021-pol2qm74 2214 20 such such JJ cord-015021-pol2qm74 2214 21 neuronal neuronal JJ cord-015021-pol2qm74 2214 22 actival.jon actival.jon NNP cord-015021-pol2qm74 2214 23 may may MD cord-015021-pol2qm74 2214 24 precede precede VB cord-015021-pol2qm74 2214 25 the the DT cord-015021-pol2qm74 2214 26 elevation elevation NN cord-015021-pol2qm74 2214 27 of of IN cord-015021-pol2qm74 2214 28 plasma plasma NN cord-015021-pol2qm74 2214 29 endotoxin endotoxin NN cord-015021-pol2qm74 2214 30 Icy.el icy.el NN cord-015021-pol2qm74 2214 31 . . . cord-015021-pol2qm74 2215 1 systemic systemic JJ cord-015021-pol2qm74 2215 2 vascular vascular JJ cord-015021-pol2qm74 2215 3 resistance resistance NN cord-015021-pol2qm74 2215 4 and and CC cord-015021-pol2qm74 2215 5 increased increase VBN cord-015021-pol2qm74 2215 6 cardiac cardiac JJ cord-015021-pol2qm74 2215 7 output output NN cord-015021-pol2qm74 2215 8 accompanied accompany VBN cord-015021-pol2qm74 2215 9 presumingly presumingly RB cord-015021-pol2qm74 2215 10 by by IN cord-015021-pol2qm74 2215 11 a a DT cord-015021-pol2qm74 2215 12 increased increase VBN cord-015021-pol2qm74 2215 13 pulmonary pulmonary JJ cord-015021-pol2qm74 2215 14 shunt shunt NN cord-015021-pol2qm74 2215 15 ( ( -LRB- cord-015021-pol2qm74 2215 16 Qs Qs NNP cord-015021-pol2qm74 2215 17 / / SYM cord-015021-pol2qm74 2215 18 Qt qt NN cord-015021-pol2qm74 2215 19 ) ) -RRB- cord-015021-pol2qm74 2215 20 . . . cord-015021-pol2qm74 2216 1 This this DT cord-015021-pol2qm74 2216 2 response response NN cord-015021-pol2qm74 2216 3 is be VBZ cord-015021-pol2qm74 2216 4 induced induce VBN cord-015021-pol2qm74 2216 5 by by IN cord-015021-pol2qm74 2216 6 prostacyclin prostacyclin NNP cord-015021-pol2qm74 2216 7 ( ( -LRB- cord-015021-pol2qm74 2216 8 PGI2 PGI2 NNP cord-015021-pol2qm74 2216 9 ) ) -RRB- cord-015021-pol2qm74 2216 10 . . . cord-015021-pol2qm74 2217 1 We -PRON- PRP cord-015021-pol2qm74 2217 2 examined examine VBD cord-015021-pol2qm74 2217 3 oxygen oxygen NN cord-015021-pol2qm74 2217 4 transport transport NN cord-015021-pol2qm74 2217 5 after after IN cord-015021-pol2qm74 2217 6 traction traction NN cord-015021-pol2qm74 2217 7 on on IN cord-015021-pol2qm74 2217 8 the the DT cord-015021-pol2qm74 2217 9 mesentery mesentery NN cord-015021-pol2qm74 2217 10 root root NN cord-015021-pol2qm74 2217 11 and and CC cord-015021-pol2qm74 2217 12 the the DT cord-015021-pol2qm74 2217 13 transpulmonary transpulmonary JJ cord-015021-pol2qm74 2217 14 prostacyclin prostacyclin NNP cord-015021-pol2qm74 2217 15 levels level NNS cord-015021-pol2qm74 2217 16 in in IN cord-015021-pol2qm74 2217 17 a a DT cord-015021-pol2qm74 2217 18 prospective prospective JJ cord-015021-pol2qm74 2217 19 placebo placebo NN cord-015021-pol2qm74 2217 20 controlled control VBN cord-015021-pol2qm74 2217 21 study study NN cord-015021-pol2qm74 2217 22 with with IN cord-015021-pol2qm74 2217 23 intravenous intravenous JJ cord-015021-pol2qm74 2217 24 ibuprofen ibuprofen NN cord-015021-pol2qm74 2217 25 . . . cord-015021-pol2qm74 2218 1 METHODS methods NN cord-015021-pol2qm74 2218 2 : : : cord-015021-pol2qm74 2219 1 With with IN cord-015021-pol2qm74 2219 2 approval approval NN cord-015021-pol2qm74 2219 3 of of IN cord-015021-pol2qm74 2219 4 the the DT cord-015021-pol2qm74 2219 5 Human human JJ cord-015021-pol2qm74 2219 6 [ [ -LRB- cord-015021-pol2qm74 2219 7 nvestigadon nvestigadon NNP cord-015021-pol2qm74 2219 8 Review Review NNP cord-015021-pol2qm74 2219 9 Board Board NNP cord-015021-pol2qm74 2219 10 we -PRON- PRP cord-015021-pol2qm74 2219 11 studied study VBD cord-015021-pol2qm74 2219 12 52 52 CD cord-015021-pol2qm74 2219 13 patients patient NNS cord-015021-pol2qm74 2219 14 in in IN cord-015021-pol2qm74 2219 15 a a DT cord-015021-pol2qm74 2219 16 prospective prospective NN cord-015021-pol2qm74 2219 17 , , , cord-015021-pol2qm74 2219 18 randomized randomized JJ cord-015021-pol2qm74 2219 19 double double JJ cord-015021-pol2qm74 2219 20 - - HYPH cord-015021-pol2qm74 2219 21 blinded blinded JJ cord-015021-pol2qm74 2219 22 protocol protocol NN cord-015021-pol2qm74 2219 23 who who WP cord-015021-pol2qm74 2219 24 were be VBD cord-015021-pol2qm74 2219 25 scheduled schedule VBN cord-015021-pol2qm74 2219 26 for for IN cord-015021-pol2qm74 2219 27 major major JJ cord-015021-pol2qm74 2219 28 abdominal abdominal JJ cord-015021-pol2qm74 2219 29 surgery surgery NN cord-015021-pol2qm74 2219 30 . . . cord-015021-pol2qm74 2220 1 Ibuprofen ibuprofen NN cord-015021-pol2qm74 2220 2 ( ( -LRB- cord-015021-pol2qm74 2220 3 400 400 CD cord-015021-pol2qm74 2220 4 mg mg NNP cord-015021-pol2qm74 2220 5 i.v i.v NNP cord-015021-pol2qm74 2220 6 . . NNP cord-015021-pol2qm74 2220 7 ) ) -RRB- cord-015021-pol2qm74 2220 8 or or CC cord-015021-pol2qm74 2220 9 a a DT cord-015021-pol2qm74 2220 10 placebo placebo NN cord-015021-pol2qm74 2220 11 equivalent equivalent NN cord-015021-pol2qm74 2220 12 was be VBD cord-015021-pol2qm74 2220 13 administered administer VBN cord-015021-pol2qm74 2220 14 15 15 CD cord-015021-pol2qm74 2220 15 minutes minute NNS cord-015021-pol2qm74 2220 16 before before IN cord-015021-pol2qm74 2220 17 skin skin NN cord-015021-pol2qm74 2220 18 incision incision NN cord-015021-pol2qm74 2220 19 . . . cord-015021-pol2qm74 2221 1 Pulmonary pulmonary JJ cord-015021-pol2qm74 2221 2 artery artery NN cord-015021-pol2qm74 2221 3 thermodilution thermodilution NN cord-015021-pol2qm74 2221 4 and and CC cord-015021-pol2qm74 2221 5 radial radial JJ cord-015021-pol2qm74 2221 6 artery artery NN cord-015021-pol2qm74 2221 7 catheters catheter NNS cord-015021-pol2qm74 2221 8 were be VBD cord-015021-pol2qm74 2221 9 placed place VBN cord-015021-pol2qm74 2221 10 after after IN cord-015021-pol2qm74 2221 11 induction induction NN cord-015021-pol2qm74 2221 12 of of IN cord-015021-pol2qm74 2221 13 anesthesia anesthesia NN cord-015021-pol2qm74 2221 14 . . . cord-015021-pol2qm74 2222 1 MT MT NNP cord-015021-pol2qm74 2222 2 was be VBD cord-015021-pol2qm74 2222 3 applied apply VBN cord-015021-pol2qm74 2222 4 in in IN cord-015021-pol2qm74 2222 5 a a DT cord-015021-pol2qm74 2222 6 uniform uniform JJ cord-015021-pol2qm74 2222 7 fashion fashion NN cord-015021-pol2qm74 2222 8 . . . cord-015021-pol2qm74 2223 1 Baseline baseline JJ cord-015021-pol2qm74 2223 2 values value NNS cord-015021-pol2qm74 2223 3 preceded precede VBD cord-015021-pol2qm74 2223 4 the the DT cord-015021-pol2qm74 2223 5 incision incision NN cord-015021-pol2qm74 2223 6 of of IN cord-015021-pol2qm74 2223 7 the the DT cord-015021-pol2qm74 2223 8 peritoneum peritoneum NN cord-015021-pol2qm74 2223 9 ( ( -LRB- cord-015021-pol2qm74 2223 10 tO to IN cord-015021-pol2qm74 2223 11 ) ) -RRB- cord-015021-pol2qm74 2223 12 . . . cord-015021-pol2qm74 2224 1 Fulther Fulther NNP cord-015021-pol2qm74 2224 2 assessments assessment NNS cord-015021-pol2qm74 2224 3 followed follow VBD cord-015021-pol2qm74 2224 4 5 5 CD cord-015021-pol2qm74 2224 5 , , , cord-015021-pol2qm74 2224 6 15 15 CD cord-015021-pol2qm74 2224 7 , , , cord-015021-pol2qm74 2224 8 30 30 CD cord-015021-pol2qm74 2224 9 , , , cord-015021-pol2qm74 2224 10 45 45 CD cord-015021-pol2qm74 2224 11 , , , cord-015021-pol2qm74 2224 12 . . . cord-015021-pol2qm74 2225 1 Tile tile NN cord-015021-pol2qm74 2225 2 plasma plasma NN cord-015021-pol2qm74 2225 3 concentrations concentration NNS cord-015021-pol2qm74 2225 4 ( ( -LRB- cord-015021-pol2qm74 2225 5 pc pc NNP cord-015021-pol2qm74 2225 6 ) ) -RRB- cord-015021-pol2qm74 2225 7 of of IN cord-015021-pol2qm74 2225 8 6-keto 6-keto CD cord-015021-pol2qm74 2225 9 - - HYPH cord-015021-pol2qm74 2225 10 PGFt PGFt NNS cord-015021-pol2qm74 2225 11 , , , cord-015021-pol2qm74 2225 12 ( ( -LRB- cord-015021-pol2qm74 2225 13 stable stable JJ cord-015021-pol2qm74 2225 14 metabolite metabolite NN cord-015021-pol2qm74 2225 15 of of IN cord-015021-pol2qm74 2225 16 PGI2 PGI2 NNP cord-015021-pol2qm74 2225 17 ) ) -RRB- cord-015021-pol2qm74 2225 18 were be VBD cord-015021-pol2qm74 2225 19 determined determine VBN cord-015021-pol2qm74 2225 20 in in IN cord-015021-pol2qm74 2225 21 arterial arterial JJ cord-015021-pol2qm74 2225 22 and and CC cord-015021-pol2qm74 2225 23 mixed mixed JJ cord-015021-pol2qm74 2225 24 venous venous JJ cord-015021-pol2qm74 2225 25 blood blood NN cord-015021-pol2qm74 2225 26 by by IN cord-015021-pol2qm74 2225 27 radioimmunoassay radioimmunoassay NN cord-015021-pol2qm74 2225 28 . . . cord-015021-pol2qm74 2226 1 At at IN cord-015021-pol2qm74 2226 2 all all DT cord-015021-pol2qm74 2226 3 points point NNS cord-015021-pol2qm74 2226 4 in in IN cord-015021-pol2qm74 2226 5 time time NN cord-015021-pol2qm74 2226 6 we -PRON- PRP cord-015021-pol2qm74 2226 7 measured measure VBD cord-015021-pol2qm74 2226 8 arterial arterial JJ cord-015021-pol2qm74 2226 9 and and CC cord-015021-pol2qm74 2226 10 mixed mixed JJ cord-015021-pol2qm74 2226 11 venous venous JJ cord-015021-pol2qm74 2226 12 blood blood NN cord-015021-pol2qm74 2226 13 gases gas NNS cord-015021-pol2qm74 2226 14 . . . cord-015021-pol2qm74 2227 1 Qs Qs NNP cord-015021-pol2qm74 2227 2 / / SYM cord-015021-pol2qm74 2227 3 Qt Qt NNP cord-015021-pol2qm74 2227 4 was be VBD cord-015021-pol2qm74 2227 5 calculated calculate VBN cord-015021-pol2qm74 2227 6 by by IN cord-015021-pol2qm74 2227 7 standard standard JJ cord-015021-pol2qm74 2227 8 formula formula NN cord-015021-pol2qm74 2227 9 . . . cord-015021-pol2qm74 2228 1 Data datum NNS cord-015021-pol2qm74 2228 2 are be VBP cord-015021-pol2qm74 2228 3 given give VBN cord-015021-pol2qm74 2228 4 as as IN cord-015021-pol2qm74 2228 5 median median NN cord-015021-pol2qm74 2228 6 ( ( -LRB- cord-015021-pol2qm74 2228 7 p p NN cord-015021-pol2qm74 2228 8 < < XX cord-015021-pol2qm74 2228 9 0.05 0.05 CD cord-015021-pol2qm74 2228 10 placebo placebo NN cord-015021-pol2qm74 2228 11 vs. vs. IN cord-015021-pol2qm74 2228 12 [ [ -LRB- cord-015021-pol2qm74 2228 13 ibuprofen ibuprofen NN cord-015021-pol2qm74 2228 14 ] ] -RRB- cord-015021-pol2qm74 2228 15 [ [ -LRB- cord-015021-pol2qm74 2228 16 117 117 CD cord-015021-pol2qm74 2228 17 ] ] -RRB- cord-015021-pol2qm74 2228 18 mmHg mmHg NNPS cord-015021-pol2qm74 2228 19 ( ( -LRB- cord-015021-pol2qm74 2228 20 * * NFP cord-015021-pol2qm74 2228 21 p p XX cord-015021-pol2qm74 2228 22 < < XX cord-015021-pol2qm74 2228 23 0.0i 0.0i CD cord-015021-pol2qm74 2228 24 ) ) -RRB- cord-015021-pol2qm74 2228 25 . . . cord-015021-pol2qm74 2229 1 These these DT cord-015021-pol2qm74 2229 2 changes change NNS cord-015021-pol2qm74 2229 3 were be VBD cord-015021-pol2qm74 2229 4 accompanied accompany VBN cord-015021-pol2qm74 2229 5 by by IN cord-015021-pol2qm74 2229 6 a a DT cord-015021-pol2qm74 2229 7 marked marked JJ cord-015021-pol2qm74 2229 8 increase increase NN cord-015021-pol2qm74 2229 9 of of IN cord-015021-pol2qm74 2230 1 6-keto 6-keto CD cord-015021-pol2qm74 2230 2 - - SYM cord-015021-pol2qm74 2230 3 PGF~ pgf~ NN cord-015021-pol2qm74 2230 4 pc pc VBP cord-015021-pol2qm74 2230 5 up up IN cord-015021-pol2qm74 2230 6 to to TO cord-015021-pol2qm74 2230 7 180 180 CD cord-015021-pol2qm74 2230 8 rain rain NN cord-015021-pol2qm74 2230 9 after after IN cord-015021-pol2qm74 2230 10 MT MT NNP cord-015021-pol2qm74 2230 11 in in IN cord-015021-pol2qm74 2230 12 arterial arterial JJ cord-015021-pol2qm74 2230 13 and and CC cord-015021-pol2qm74 2230 14 mixed mixed JJ cord-015021-pol2qm74 2230 15 venous venous JJ cord-015021-pol2qm74 2230 16 blood blood NN cord-015021-pol2qm74 2230 17 of of IN cord-015021-pol2qm74 2230 18 untreated untreated JJ cord-015021-pol2qm74 2230 19 patients patient NNS cord-015021-pol2qm74 2230 20 with with IN cord-015021-pol2qm74 2230 21 a a DT cord-015021-pol2qm74 2230 22 peak peak NN cord-015021-pol2qm74 2230 23 of of IN cord-015021-pol2qm74 2230 24 2450*[60 2450*[60 CD cord-015021-pol2qm74 2230 25 ] ] -RRB- cord-015021-pol2qm74 2231 1 ng ng NNP cord-015021-pol2qm74 2231 2 / / SYM cord-015021-pol2qm74 2231 3 l l NNP cord-015021-pol2qm74 2231 4 tl tl NNP cord-015021-pol2qm74 2232 1 ( ( -LRB- cord-015021-pol2qm74 2232 2 * * NFP cord-015021-pol2qm74 2232 3 p p XX cord-015021-pol2qm74 2232 4 < < XX cord-015021-pol2qm74 2232 5 0.00Ol 0.00Ol NFP cord-015021-pol2qm74 2232 6 ) ) -RRB- cord-015021-pol2qm74 2232 7 . . . cord-015021-pol2qm74 2233 1 There there EX cord-015021-pol2qm74 2233 2 was be VBD cord-015021-pol2qm74 2233 3 no no DT cord-015021-pol2qm74 2233 4 difference difference NN cord-015021-pol2qm74 2233 5 between between IN cord-015021-pol2qm74 2233 6 arterial arterial NN cord-015021-pol2qm74 2233 7 and and CC cord-015021-pol2qm74 2233 8 mixed mixed JJ cord-015021-pol2qm74 2233 9 venous venous JJ cord-015021-pol2qm74 2233 10 pc pc NN cord-015021-pol2qm74 2233 11 . . . cord-015021-pol2qm74 2234 1 Ibuprofen ibuprofen NN cord-015021-pol2qm74 2234 2 pretreated pretreate VBD cord-015021-pol2qm74 2234 3 patients patient NNS cord-015021-pol2qm74 2234 4 ( ( -LRB- cord-015021-pol2qm74 2234 5 n n NN cord-015021-pol2qm74 2234 6 = = SYM cord-015021-pol2qm74 2234 7 zr zr NNP cord-015021-pol2qm74 2234 8 ) ) -RRB- cord-015021-pol2qm74 2234 9 demonstrated demonstrate VBD cord-015021-pol2qm74 2234 10 stabile stabile JJ cord-015021-pol2qm74 2234 11 Qs Qs NNP cord-015021-pol2qm74 2234 12 / / SYM cord-015021-pol2qm74 2234 13 Qt qt NN cord-015021-pol2qm74 2234 14 and and CC cord-015021-pol2qm74 2234 15 paO2 pao2 NN cord-015021-pol2qm74 2234 16 while while IN cord-015021-pol2qm74 2234 17 6-keto 6-keto CD cord-015021-pol2qm74 2234 18 - - HYPH cord-015021-pol2qm74 2234 19 PGF~ PGF~ NNP cord-015021-pol2qm74 2234 20 pc pc NN cord-015021-pol2qm74 2234 21 remained remain VBD cord-015021-pol2qm74 2234 22 within within IN cord-015021-pol2qm74 2234 23 the the DT cord-015021-pol2qm74 2234 24 normal normal JJ cord-015021-pol2qm74 2234 25 range range NN cord-015021-pol2qm74 2234 26 . . . cord-015021-pol2qm74 2235 1 DISCUSSION discussion NN cord-015021-pol2qm74 2235 2 : : : cord-015021-pol2qm74 2236 1 Our -PRON- PRP$ cord-015021-pol2qm74 2236 2 data datum NNS cord-015021-pol2qm74 2236 3 clearly clearly RB cord-015021-pol2qm74 2236 4 indicate indicate VBP cord-015021-pol2qm74 2236 5 that that IN cord-015021-pol2qm74 2236 6 mesenteric mesenteric JJ cord-015021-pol2qm74 2236 7 traction traction NN cord-015021-pol2qm74 2236 8 response response NN cord-015021-pol2qm74 2236 9 includes include VBZ cord-015021-pol2qm74 2236 10 a a DT cord-015021-pol2qm74 2236 11 critical critical JJ cord-015021-pol2qm74 2236 12 rise rise NN cord-015021-pol2qm74 2236 13 in in IN cord-015021-pol2qm74 2236 14 Qs Qs NNP cord-015021-pol2qm74 2236 15 / / SYM cord-015021-pol2qm74 2236 16 Qt Qt NNP cord-015021-pol2qm74 2236 17 followed follow VBN cord-015021-pol2qm74 2236 18 by by IN cord-015021-pol2qm74 2236 19 significant significant JJ cord-015021-pol2qm74 2236 20 decrease decrease NN cord-015021-pol2qm74 2236 21 of of IN cord-015021-pol2qm74 2236 22 paOv paov NN cord-015021-pol2qm74 2236 23 Stable stable JJ cord-015021-pol2qm74 2236 24 oxygen oxygen NN cord-015021-pol2qm74 2236 25 transport transport NN cord-015021-pol2qm74 2236 26 determinants determinant NNS cord-015021-pol2qm74 2236 27 following follow VBG cord-015021-pol2qm74 2236 28 cyclooxygenase cyclooxygenase NN cord-015021-pol2qm74 2236 29 inhibition inhibition NN cord-015021-pol2qm74 2236 30 signify signify VBP cord-015021-pol2qm74 2236 31 an an DT cord-015021-pol2qm74 2236 32 action action NN cord-015021-pol2qm74 2236 33 mediated mediate VBN cord-015021-pol2qm74 2236 34 by by IN cord-015021-pol2qm74 2236 35 prostacyclin prostacyclin NNP cord-015021-pol2qm74 2236 36 . . . cord-015021-pol2qm74 2237 1 An an DT cord-015021-pol2qm74 2237 2 indicative indicative JJ cord-015021-pol2qm74 2237 3 transpulmonary transpulmonary JJ cord-015021-pol2qm74 2237 4 gradient gradient NN cord-015021-pol2qm74 2237 5 for for IN cord-015021-pol2qm74 2238 1 6-keto 6-keto NNP cord-015021-pol2qm74 2238 2 - - : cord-015021-pol2qm74 2238 3 PGFt~ PGFt~ NNP cord-015021-pol2qm74 2238 4 was be VBD cord-015021-pol2qm74 2238 5 not not RB cord-015021-pol2qm74 2238 6 detectable detectable JJ cord-015021-pol2qm74 2238 7 . . . cord-015021-pol2qm74 2239 1 A a DT cord-015021-pol2qm74 2239 2 splanchnic splanchnic JJ cord-015021-pol2qm74 2239 3 vascular vascular JJ cord-015021-pol2qm74 2239 4 source source NN cord-015021-pol2qm74 2239 5 for for IN cord-015021-pol2qm74 2239 6 PGI2 PGI2 NNP cord-015021-pol2qm74 2239 7 release release NN cord-015021-pol2qm74 2239 8 seems seem VBZ cord-015021-pol2qm74 2239 9 to to TO cord-015021-pol2qm74 2239 10 be be VB cord-015021-pol2qm74 2239 11 likely likely JJ cord-015021-pol2qm74 2239 12 , , , cord-015021-pol2qm74 2239 13 but but CC cord-015021-pol2qm74 2239 14 could could MD cord-015021-pol2qm74 2239 15 not not RB cord-015021-pol2qm74 2239 16 be be VB cord-015021-pol2qm74 2239 17 proved prove VBN cord-015021-pol2qm74 2239 18 by by IN cord-015021-pol2qm74 2239 19 our -PRON- PRP$ cord-015021-pol2qm74 2239 20 current current JJ cord-015021-pol2qm74 2239 21 data datum NNS cord-015021-pol2qm74 2239 22 . . . cord-015021-pol2qm74 2240 1 Department Department NNP cord-015021-pol2qm74 2240 2 of of IN cord-015021-pol2qm74 2240 3 Anesthesiology Anesthesiology NNP cord-015021-pol2qm74 2240 4 , , , cord-015021-pol2qm74 2240 5 Cliu Cliu NNP cord-015021-pol2qm74 2240 6 . . . cord-015021-pol2qm74 2241 1 Chemistry chemistry NN cord-015021-pol2qm74 2241 2 * * NFP cord-015021-pol2qm74 2241 3 and and CC cord-015021-pol2qm74 2241 4 Surgery surgery NN cord-015021-pol2qm74 2241 5 * * NFP cord-015021-pol2qm74 2241 6 ; ; : cord-015021-pol2qm74 2241 7 University University NNP cord-015021-pol2qm74 2241 8 Clinics Clinics NNPS cord-015021-pol2qm74 2241 9 UIm UIm NNS cord-015021-pol2qm74 2241 10 , , , cord-015021-pol2qm74 2241 11 Prittwitzstral]e Prittwitzstral]e NNP cord-015021-pol2qm74 2241 12 43 43 CD cord-015021-pol2qm74 2241 13 , , , cord-015021-pol2qm74 2241 14 89075 89075 CD cord-015021-pol2qm74 2241 15 Ulm Ulm NNP cord-015021-pol2qm74 2241 16 , , , cord-015021-pol2qm74 2241 17 Germany Germany NNP cord-015021-pol2qm74 2242 1 It -PRON- PRP cord-015021-pol2qm74 2242 2 is be VBZ cord-015021-pol2qm74 2242 3 unclear unclear JJ cord-015021-pol2qm74 2242 4 whether whether IN cord-015021-pol2qm74 2242 5 injuries injury NNS cord-015021-pol2qm74 2242 6 like like IN cord-015021-pol2qm74 2242 7 bums bum NNS cord-015021-pol2qm74 2242 8 , , , cord-015021-pol2qm74 2242 9 in in IN cord-015021-pol2qm74 2242 10 general general JJ cord-015021-pol2qm74 2242 11 , , , cord-015021-pol2qm74 2242 12 directly directly RB cord-015021-pol2qm74 2242 13 result result VB cord-015021-pol2qm74 2242 14 in in IN cord-015021-pol2qm74 2242 15 alterations alteration NNS cord-015021-pol2qm74 2242 16 of of IN cord-015021-pol2qm74 2242 17 cell cell NN cord-015021-pol2qm74 2242 18 - - HYPH cord-015021-pol2qm74 2242 19 mediated mediate VBN cord-015021-pol2qm74 2242 20 immunity immunity NN cord-015021-pol2qm74 2242 21 that that WDT cord-015021-pol2qm74 2242 22 , , , cord-015021-pol2qm74 2242 23 in in IN cord-015021-pol2qm74 2242 24 turn turn NN cord-015021-pol2qm74 2242 25 , , , cord-015021-pol2qm74 2242 26 promote promote VB cord-015021-pol2qm74 2242 27 endotoxic endotoxic JJ cord-015021-pol2qm74 2242 28 and and CC cord-015021-pol2qm74 2242 29 bacterial bacterial JJ cord-015021-pol2qm74 2242 30 translocation translocation NN cord-015021-pol2qm74 2242 31 or or CC cord-015021-pol2qm74 2242 32 , , , cord-015021-pol2qm74 2242 33 alternatively alternatively RB cord-015021-pol2qm74 2242 34 , , , cord-015021-pol2qm74 2242 35 whether whether IN cord-015021-pol2qm74 2242 36 these these DT cord-015021-pol2qm74 2242 37 conditions condition NNS cord-015021-pol2qm74 2242 38 allow allow VBP cord-015021-pol2qm74 2242 39 increased increase VBN cord-015021-pol2qm74 2242 40 bacterial bacterial JJ cord-015021-pol2qm74 2242 41 invasion invasion NN cord-015021-pol2qm74 2242 42 that that WDT cord-015021-pol2qm74 2242 43 , , , cord-015021-pol2qm74 2242 44 in in IN cord-015021-pol2qm74 2242 45 turn turn NN cord-015021-pol2qm74 2242 46 , , , cord-015021-pol2qm74 2242 47 inhibits inhibit VBZ cord-015021-pol2qm74 2242 48 CMI CMI NNP cord-015021-pol2qm74 2242 49 . . . cord-015021-pol2qm74 2243 1 Aim aim VB cord-015021-pol2qm74 2243 2 : : : cord-015021-pol2qm74 2243 3 To to TO cord-015021-pol2qm74 2243 4 determine determine VB cord-015021-pol2qm74 2243 5 whether whether IN cord-015021-pol2qm74 2243 6 infectious infectious JJ cord-015021-pol2qm74 2243 7 challenge challenge NN cord-015021-pol2qm74 2243 8 , , , cord-015021-pol2qm74 2243 9 as as IN cord-015021-pol2qm74 2243 10 CLP CLP NNP cord-015021-pol2qm74 2243 11 alone alone RB cord-015021-pol2qm74 2243 12 or or CC cord-015021-pol2qm74 2243 13 combined combine VBN cord-015021-pol2qm74 2243 14 with with IN cord-015021-pol2qm74 2243 15 TI TI NNP cord-015021-pol2qm74 2243 16 causes cause VBZ cord-015021-pol2qm74 2243 17 further further JJ cord-015021-pol2qm74 2243 18 immune immune JJ cord-015021-pol2qm74 2243 19 abnormalities abnormality NNS cord-015021-pol2qm74 2243 20 in in IN cord-015021-pol2qm74 2243 21 the the DT cord-015021-pol2qm74 2243 22 days day NNS cord-015021-pol2qm74 2243 23 following follow VBG cord-015021-pol2qm74 2243 24 CLP CLP NNP cord-015021-pol2qm74 2243 25 . . . cord-015021-pol2qm74 2244 1 Study study NN cord-015021-pol2qm74 2244 2 Plan Plan NNP cord-015021-pol2qm74 2244 3 : : : cord-015021-pol2qm74 2244 4 On on IN cord-015021-pol2qm74 2244 5 day day NN cord-015021-pol2qm74 2244 6 1 1 CD cord-015021-pol2qm74 2244 7 , , , cord-015021-pol2qm74 2244 8 two two CD cord-015021-pol2qm74 2244 9 groups group NNS cord-015021-pol2qm74 2244 10 of of IN cord-015021-pol2qm74 2244 11 n=36 n=36 NNS cord-015021-pol2qm74 2244 12 8 8 CD cord-015021-pol2qm74 2244 13 week week NN cord-015021-pol2qm74 2244 14 old old JJ cord-015021-pol2qm74 2244 15 AJ AJ NNP cord-015021-pol2qm74 2244 16 mice mouse NNS cord-015021-pol2qm74 2244 17 were be VBD cord-015021-pol2qm74 2244 18 subjected subject VBN cord-015021-pol2qm74 2244 19 to to IN cord-015021-pol2qm74 2244 20 either either CC cord-015021-pol2qm74 2244 21 a a DT cord-015021-pol2qm74 2244 22 20 20 CD cord-015021-pol2qm74 2244 23 % % NN cord-015021-pol2qm74 2244 24 scold scold NN cord-015021-pol2qm74 2244 25 burn burn NN cord-015021-pol2qm74 2244 26 ( ( -LRB- cord-015021-pol2qm74 2244 27 TI TI NNP cord-015021-pol2qm74 2244 28 ) ) -RRB- cord-015021-pol2qm74 2244 29 , , , cord-015021-pol2qm74 2244 30 or or CC cord-015021-pol2qm74 2244 31 were be VBD cord-015021-pol2qm74 2244 32 untreated untreated JJ cord-015021-pol2qm74 2244 33 ( ( -LRB- cord-015021-pol2qm74 2244 34 C C NNP cord-015021-pol2qm74 2244 35 ) ) -RRB- cord-015021-pol2qm74 2244 36 n=18 n=18 RB cord-015021-pol2qm74 2244 37 . . . cord-015021-pol2qm74 2245 1 On on IN cord-015021-pol2qm74 2245 2 day day NN cord-015021-pol2qm74 2245 3 10 10 CD cord-015021-pol2qm74 2245 4 , , , cord-015021-pol2qm74 2245 5 18 18 CD cord-015021-pol2qm74 2245 6 mice mouse NNS cord-015021-pol2qm74 2245 7 ( ( -LRB- cord-015021-pol2qm74 2245 8 TI+CLP TI+CLP NNP cord-015021-pol2qm74 2245 9 ) ) -RRB- cord-015021-pol2qm74 2245 10 and and CC cord-015021-pol2qm74 2245 11 24 24 CD cord-015021-pol2qm74 2245 12 mice mouse NNS cord-015021-pol2qm74 2245 13 ( ( -LRB- cord-015021-pol2qm74 2245 14 CLP CLP NNP cord-015021-pol2qm74 2245 15 ) ) -RRB- cord-015021-pol2qm74 2245 16 were be VBD cord-015021-pol2qm74 2245 17 subjected subject VBN cord-015021-pol2qm74 2245 18 to to IN cord-015021-pol2qm74 2245 19 CLP CLP NNP cord-015021-pol2qm74 2245 20 . . . cord-015021-pol2qm74 2246 1 The the DT cord-015021-pol2qm74 2246 2 two two CD cord-015021-pol2qm74 2246 3 other other JJ cord-015021-pol2qm74 2246 4 groups group NNS cord-015021-pol2qm74 2246 5 ( ( -LRB- cord-015021-pol2qm74 2246 6 TI TI NNP cord-015021-pol2qm74 2246 7 and and CC cord-015021-pol2qm74 2246 8 C C NNP cord-015021-pol2qm74 2246 9 ) ) -RRB- cord-015021-pol2qm74 2246 10 were be VBD cord-015021-pol2qm74 2246 11 untreated untreated JJ cord-015021-pol2qm74 2246 12 . . . cord-015021-pol2qm74 2247 1 At at IN cord-015021-pol2qm74 2247 2 days day NNS cord-015021-pol2qm74 2247 3 11 11 CD cord-015021-pol2qm74 2247 4 , , , cord-015021-pol2qm74 2247 5 12 12 CD cord-015021-pol2qm74 2247 6 and and CC cord-015021-pol2qm74 2247 7 13 13 CD cord-015021-pol2qm74 2247 8 after after IN cord-015021-pol2qm74 2247 9 thermal thermal JJ cord-015021-pol2qm74 2247 10 injury injury NN cord-015021-pol2qm74 2247 11 splenocytes splenocytes FW cord-015021-pol2qm74 2247 12 ( ( -LRB- cord-015021-pol2qm74 2247 13 SP SP NNP cord-015021-pol2qm74 2247 14 ) ) -RRB- cord-015021-pol2qm74 2247 15 were be VBD cord-015021-pol2qm74 2247 16 harvested harvest VBN cord-015021-pol2qm74 2247 17 and and CC cord-015021-pol2qm74 2247 18 cultured culture VBN cord-015021-pol2qm74 2247 19 with with IN cord-015021-pol2qm74 2247 20 ConA ConA NNP cord-015021-pol2qm74 2247 21 for for IN cord-015021-pol2qm74 2247 22 an an DT cord-015021-pol2qm74 2247 23 assay assay NN cord-015021-pol2qm74 2247 24 of of IN cord-015021-pol2qm74 2247 25 IL-2 il-2 NN cord-015021-pol2qm74 2247 26 and and CC cord-015021-pol2qm74 2247 27 adherent adherent JJ cord-015021-pol2qm74 2247 28 splenocytes splenocytes NNP cord-015021-pol2qm74 2247 29 ( ( -LRB- cord-015021-pol2qm74 2247 30 AS AS NNP cord-015021-pol2qm74 2247 31 ) ) -RRB- cord-015021-pol2qm74 2247 32 were be VBD cord-015021-pol2qm74 2247 33 cultured culture VBN cord-015021-pol2qm74 2247 34 with with IN cord-015021-pol2qm74 2247 35 LPS LPS NNP cord-015021-pol2qm74 2247 36 for for IN cord-015021-pol2qm74 2247 37 IL-1 IL-1 NNP cord-015021-pol2qm74 2247 38 , , , cord-015021-pol2qm74 2247 39 TNF TNF NNP cord-015021-pol2qm74 2247 40 , , , cord-015021-pol2qm74 2247 41 IL-6 IL-6 NNP cord-015021-pol2qm74 2247 42 and and CC cord-015021-pol2qm74 2247 43 PGE2 PGE2 NNP cord-015021-pol2qm74 2247 44 . . . cord-015021-pol2qm74 2248 1 Results result NNS cord-015021-pol2qm74 2248 2 : : : cord-015021-pol2qm74 2249 1 Either either CC cord-015021-pol2qm74 2249 2 TI TI NNP cord-015021-pol2qm74 2249 3 + + CC cord-015021-pol2qm74 2249 4 CLP clp NN cord-015021-pol2qm74 2249 5 or or CC cord-015021-pol2qm74 2249 6 CLP CLP NNP cord-015021-pol2qm74 2249 7 alone alone RB cord-015021-pol2qm74 2249 8 result result VBP cord-015021-pol2qm74 2249 9 in in IN cord-015021-pol2qm74 2249 10 significantly significantly RB cord-015021-pol2qm74 2249 11 decreased decrease VBD cord-015021-pol2qm74 2249 12 secretion secretion NN cord-015021-pol2qm74 2249 13 of of IN cord-015021-pol2qm74 2249 14 all all DT cord-015021-pol2qm74 2249 15 cytokines cytokine NNS cord-015021-pol2qm74 2249 16 tested test VBN cord-015021-pol2qm74 2249 17 . . . cord-015021-pol2qm74 2250 1 In in IN cord-015021-pol2qm74 2250 2 the the DT cord-015021-pol2qm74 2250 3 TI TI NNP cord-015021-pol2qm74 2250 4 group group NN cord-015021-pol2qm74 2250 5 almost almost RB cord-015021-pol2qm74 2250 6 every every DT cord-015021-pol2qm74 2250 7 cytokine cytokine NN cord-015021-pol2qm74 2250 8 production production NN cord-015021-pol2qm74 2250 9 determined determine VBN cord-015021-pol2qm74 2250 10 was be VBD cord-015021-pol2qm74 2250 11 elevated elevate VBN cord-015021-pol2qm74 2250 12 in in IN cord-015021-pol2qm74 2250 13 comparison comparison NN cord-015021-pol2qm74 2250 14 to to IN cord-015021-pol2qm74 2250 15 TI TI NNP cord-015021-pol2qm74 2250 16 + + CC cord-015021-pol2qm74 2250 17 CLP clp NN cord-015021-pol2qm74 2250 18 and and CC cord-015021-pol2qm74 2250 19 Prosmcyclin Prosmcyclin NNP cord-015021-pol2qm74 2250 20 ( ( -LRB- cord-015021-pol2qm74 2250 21 PGI2 PGI2 NNP cord-015021-pol2qm74 2250 22 ) ) -RRB- cord-015021-pol2qm74 2250 23 has have VBZ cord-015021-pol2qm74 2250 24 been be VBN cord-015021-pol2qm74 2250 25 implicated implicate VBN cord-015021-pol2qm74 2250 26 in in IN cord-015021-pol2qm74 2250 27 the the DT cord-015021-pol2qm74 2250 28 pathophysiology pathophysiology NN cord-015021-pol2qm74 2250 29 of of IN cord-015021-pol2qm74 2250 30 septic septic JJ cord-015021-pol2qm74 2250 31 shock shock NN cord-015021-pol2qm74 2250 32 . . . cord-015021-pol2qm74 2251 1 However however RB cord-015021-pol2qm74 2251 2 , , , cord-015021-pol2qm74 2251 3 PGI~ PGI~ NNP cord-015021-pol2qm74 2251 4 's 's POS cord-015021-pol2qm74 2251 5 role role NN cord-015021-pol2qm74 2251 6 in in IN cord-015021-pol2qm74 2251 7 the the DT cord-015021-pol2qm74 2251 8 inflammatory inflammatory JJ cord-015021-pol2qm74 2251 9 response response NN cord-015021-pol2qm74 2251 10 to to IN cord-015021-pol2qm74 2251 11 sepsis sepsis NN cord-015021-pol2qm74 2251 12 is be VBZ cord-015021-pol2qm74 2251 13 not not RB cord-015021-pol2qm74 2251 14 well well RB cord-015021-pol2qm74 2251 15 - - HYPH cord-015021-pol2qm74 2251 16 defined define VBN cord-015021-pol2qm74 2251 17 . . . cord-015021-pol2qm74 2252 1 The the DT cord-015021-pol2qm74 2252 2 purpose purpose NN cord-015021-pol2qm74 2252 3 of of IN cord-015021-pol2qm74 2252 4 this this DT cord-015021-pol2qm74 2252 5 study study NN cord-015021-pol2qm74 2252 6 was be VBD cord-015021-pol2qm74 2252 7 to to TO cord-015021-pol2qm74 2252 8 identify identify VB cord-015021-pol2qm74 2252 9 which which WDT cord-015021-pol2qm74 2252 10 acute acute JJ cord-015021-pol2qm74 2252 11 septic septic JJ cord-015021-pol2qm74 2252 12 events event NNS cord-015021-pol2qm74 2252 13 are be VBP cord-015021-pol2qm74 2252 14 mediated mediate VBN cord-015021-pol2qm74 2252 15 by by IN cord-015021-pol2qm74 2252 16 PGI PGI NNP cord-015021-pol2qm74 2252 17 2 2 CD cord-015021-pol2qm74 2252 18 during during IN cord-015021-pol2qm74 2252 19 graded grade VBN cord-015021-pol2qm74 2252 20 bacteremia bacteremia NN cord-015021-pol2qm74 2252 21 . . . cord-015021-pol2qm74 2253 1 METHODS methods NN cord-015021-pol2qm74 2253 2 : : : cord-015021-pol2qm74 2254 1 Eleven Eleven NNP cord-015021-pol2qm74 2254 2 ~nesrhetized ~nesrhetized XX cord-015021-pol2qm74 2254 3 , , , cord-015021-pol2qm74 2254 4 hemodynamically hemodynamically RB cord-015021-pol2qm74 2254 5 monitored monitor VBD cord-015021-pol2qm74 2254 6 adult adult NN cord-015021-pol2qm74 2254 7 swine swine NN cord-015021-pol2qm74 2254 8 were be VBD cord-015021-pol2qm74 2254 9 infused infuse VBN cord-015021-pol2qm74 2254 10 IV IV NNP cord-015021-pol2qm74 2254 11 with with IN cord-015021-pol2qm74 2254 12 Aeromonas Aeromonas NNP cord-015021-pol2qm74 2254 13 h. h. NNP cord-015021-pol2qm74 2254 14 ( ( -LRB- cord-015021-pol2qm74 2254 15 109 109 CD cord-015021-pol2qm74 2254 16 / / SYM cord-015021-pol2qm74 2254 17 ml ml NN cord-015021-pol2qm74 2254 18 ) ) -RRB- cord-015021-pol2qm74 2254 19 at at IN cord-015021-pol2qm74 2254 20 rates rate NNS cord-015021-pol2qm74 2254 21 increased increase VBD cord-015021-pol2qm74 2254 22 incrementally incrementally RB cord-015021-pol2qm74 2254 23 from from IN cord-015021-pol2qm74 2254 24 0.2 0.2 CD cord-015021-pol2qm74 2254 25 to to IN cord-015021-pol2qm74 2254 26 4.0 4.0 CD cord-015021-pol2qm74 2254 27 mI mI NNS cord-015021-pol2qm74 2254 28 / / SYM cord-015021-pol2qm74 2254 29 kg kg NN cord-015021-pol2qm74 2254 30 / / SYM cord-015021-pol2qm74 2254 31 hr hr NN cord-015021-pol2qm74 2254 32 over over IN cord-015021-pol2qm74 2254 33 4 4 CD cord-015021-pol2qm74 2254 34 hours hour NNS cord-015021-pol2qm74 2254 35 . . . cord-015021-pol2qm74 2255 1 Animals animal NNS cord-015021-pol2qm74 2255 2 were be VBD cord-015021-pol2qm74 2255 3 studied study VBN cord-015021-pol2qm74 2255 4 in in IN cord-015021-pol2qm74 2255 5 two two CD cord-015021-pol2qm74 2255 6 groups group NNS cord-015021-pol2qm74 2255 7 : : : cord-015021-pol2qm74 2255 8 septic septic JJ cord-015021-pol2qm74 2255 9 control control NN cord-015021-pol2qm74 2255 10 ( ( -LRB- cord-015021-pol2qm74 2255 11 SC SC NNP cord-015021-pol2qm74 2255 12 ) ) -RRB- cord-015021-pol2qm74 2255 13 , , , cord-015021-pol2qm74 2255 14 graded grade VBN cord-015021-pol2qm74 2255 15 bacteremia bacteremia NN cord-015021-pol2qm74 2255 16 only only RB cord-015021-pol2qm74 2255 17 ( ( -LRB- cord-015021-pol2qm74 2255 18 n=6 n=6 NNP cord-015021-pol2qm74 2255 19 ) ) -RRB- cord-015021-pol2qm74 2255 20 ; ; : cord-015021-pol2qm74 2255 21 PGA PGA NNP cord-015021-pol2qm74 2255 22 ( ( -LRB- cord-015021-pol2qm74 2255 23 n=5 n=5 NNP cord-015021-pol2qm74 2255 24 ) ) -RRB- cord-015021-pol2qm74 2255 25 , , , cord-015021-pol2qm74 2255 26 graded grade VBN cord-015021-pol2qm74 2255 27 bacteremta bacteremta NNP cord-015021-pol2qm74 2255 28 plus plus CC cord-015021-pol2qm74 2255 29 anti anti JJ cord-015021-pol2qm74 2255 30 - - JJ cord-015021-pol2qm74 2255 31 PGIz pgiz JJ cord-015021-pol2qm74 2255 32 antibody antibody NN cord-015021-pol2qm74 2255 33 , , , cord-015021-pol2qm74 2255 34 50 50 CD cord-015021-pol2qm74 2255 35 ml ml NNS cord-015021-pol2qm74 2255 36 / / SYM cord-015021-pol2qm74 2255 37 hr hr NN cord-015021-pol2qm74 2255 38 IV IV NNP cord-015021-pol2qm74 2255 39 , , , cord-015021-pol2qm74 2255 40 beginning begin VBG cord-015021-pol2qm74 2255 41 at at IN cord-015021-pol2qm74 2255 42 2 2 CD cord-015021-pol2qm74 2255 43 hours hour NNS cord-015021-pol2qm74 2255 44 . . . cord-015021-pol2qm74 2256 1 Mean mean JJ cord-015021-pol2qm74 2256 2 systemic systemic JJ cord-015021-pol2qm74 2256 3 ( ( -LRB- cord-015021-pol2qm74 2256 4 MAP map NN cord-015021-pol2qm74 2256 5 ) ) -RRB- cord-015021-pol2qm74 2256 6 and and CC cord-015021-pol2qm74 2256 7 pulmonary pulmonary JJ cord-015021-pol2qm74 2256 8 arterial arterial NN cord-015021-pol2qm74 2256 9 ( ( -LRB- cord-015021-pol2qm74 2256 10 PAP pap NN cord-015021-pol2qm74 2256 11 ) ) -RRB- cord-015021-pol2qm74 2256 12 pressures pressure NNS cord-015021-pol2qm74 2256 13 and and CC cord-015021-pol2qm74 2256 14 arterial arterial JJ cord-015021-pol2qm74 2256 15 pO2 po2 NN cord-015021-pol2qm74 2256 16 , , , cord-015021-pol2qm74 2256 17 mmHg mmHg NNP cord-015021-pol2qm74 2256 18 , , , cord-015021-pol2qm74 2256 19 cardiac cardiac JJ cord-015021-pol2qm74 2256 20 index index NN cord-015021-pol2qm74 2256 21 ( ( -LRB- cord-015021-pol2qm74 2256 22 CI CI NNP cord-015021-pol2qm74 2256 23 ) ) -RRB- cord-015021-pol2qm74 2256 24 , , , cord-015021-pol2qm74 2256 25 L L NNP cord-015021-pol2qm74 2256 26 / / SYM cord-015021-pol2qm74 2256 27 min min NNP cord-015021-pol2qm74 2256 28 / / SYM cord-015021-pol2qm74 2256 29 M2 M2 NNP cord-015021-pol2qm74 2256 30 , , , cord-015021-pol2qm74 2256 31 oxygen oxygen NN cord-015021-pol2qm74 2256 32 delivery delivery NN cord-015021-pol2qm74 2256 33 index index NN cord-015021-pol2qm74 2256 34 ( ( -LRB- cord-015021-pol2qm74 2256 35 DO2I do2i NN cord-015021-pol2qm74 2256 36 ) ) -RRB- cord-015021-pol2qm74 2256 37 and and CC cord-015021-pol2qm74 2256 38 consumption consumption NN cord-015021-pol2qm74 2256 39 index index NN cord-015021-pol2qm74 2256 40 ( ( -LRB- cord-015021-pol2qm74 2256 41 VOzI VOzI NNP cord-015021-pol2qm74 2256 42 ) ) -RRB- cord-015021-pol2qm74 2256 43 , , , cord-015021-pol2qm74 2256 44 ml ml NN cord-015021-pol2qm74 2256 45 / / SYM cord-015021-pol2qm74 2256 46 min min NNP cord-015021-pol2qm74 2256 47 / / SYM cord-015021-pol2qm74 2256 48 M2 M2 NNP cord-015021-pol2qm74 2256 49 , , , cord-015021-pol2qm74 2256 50 and and CC cord-015021-pol2qm74 2256 51 oxygen oxygen NN cord-015021-pol2qm74 2256 52 extraction extraction NN cord-015021-pol2qm74 2256 53 ( ( -LRB- cord-015021-pol2qm74 2256 54 ER ER NNP cord-015021-pol2qm74 2256 55 ) ) -RRB- cord-015021-pol2qm74 2256 56 , , , cord-015021-pol2qm74 2256 57 % % NN cord-015021-pol2qm74 2256 58 , , , cord-015021-pol2qm74 2256 59 ) ) -RRB- cord-015021-pol2qm74 2256 60 latelet latelet NNP cord-015021-pol2qm74 2256 61 aggregometry aggregometry NNP cord-015021-pol2qm74 2256 62 ( ( -LRB- cord-015021-pol2qm74 2256 63 PLT PLT NNP cord-015021-pol2qm74 2256 64 ) ) -RRB- cord-015021-pol2qm74 2256 65 , , , cord-015021-pol2qm74 2256 66 % % NN cord-015021-pol2qm74 2256 67 max max NN cord-015021-pol2qm74 2256 68 . . . cord-015021-pol2qm74 2257 1 , , , cord-015021-pol2qm74 2257 2 plasma plasma NNP cord-015021-pol2qm74 2257 3 PG6-keto PG6-keto NNP cord-015021-pol2qm74 2257 4 F1 f1 NN cord-015021-pol2qm74 2257 5 alpha alpha NN cord-015021-pol2qm74 2257 6 ; ; . cord-015021-pol2qm74 2257 7 In in IN cord-015021-pol2qm74 2257 8 the the DT cord-015021-pol2qm74 2257 9 first first JJ cord-015021-pol2qm74 2257 10 instance~ instance~ NNP cord-015021-pol2qm74 2257 11 peak peak NN cord-015021-pol2qm74 2257 12 values value NNS cord-015021-pol2qm74 2257 13 of of IN cord-015021-pol2qm74 2257 14 LT LT NNP cord-015021-pol2qm74 2257 15 ~4 ~4 CD cord-015021-pol2qm74 2257 16 after after IN cord-015021-pol2qm74 2257 17 i~ i~ CD cord-015021-pol2qm74 2257 18 hrs hrs NN cord-015021-pol2qm74 2257 19 post post NN cord-015021-pol2qm74 2257 20 infarction infarction NN cord-015021-pol2qm74 2257 21 were be VBD cord-015021-pol2qm74 2257 22 6 6 CD cord-015021-pol2qm74 2257 23 times time NNS cord-015021-pol2qm74 2257 24 higher high JJR cord-015021-pol2qm74 2257 25 than than IN cord-015021-pol2qm74 2257 26 in in IN cord-015021-pol2qm74 2257 27 the the DT cord-015021-pol2qm74 2257 28 controls control NNS cord-015021-pol2qm74 2257 29 and and CC cord-015021-pol2qm74 2257 30 excess excess JJ cord-015021-pol2qm74 2257 31 leucocyte leucocyte JJ cord-015021-pol2qm74 2257 32 infiltration infiltration NN cord-015021-pol2qm74 2257 33 was be VBD cord-015021-pol2qm74 2257 34 noted note VBN cord-015021-pol2qm74 2257 35 at at IN cord-015021-pol2qm74 2257 36 the the DT cord-015021-pol2qm74 2257 37 infarction infarction NN cord-015021-pol2qm74 2257 38 zone zone NN cord-015021-pol2qm74 2257 39 . . . cord-015021-pol2qm74 2258 1 In in IN cord-015021-pol2qm74 2258 2 second second JJ cord-015021-pol2qm74 2258 3 instance instance NN cord-015021-pol2qm74 2258 4 two two CD cord-015021-pol2qm74 2258 5 levels level NNS cord-015021-pol2qm74 2258 6 of of IN cord-015021-pol2qm74 2258 7 LT LT NNP cord-015021-pol2qm74 2258 8 B4 B4 NNP cord-015021-pol2qm74 2258 9 led lead VBD cord-015021-pol2qm74 2258 10 to to IN cord-015021-pol2qm74 2258 11 weak weak JJ cord-015021-pol2qm74 2258 12 infiltration infiltration NN cord-015021-pol2qm74 2258 13 of of IN cord-015021-pol2qm74 2258 14 the the DT cord-015021-pol2qm74 2258 15 infarction infarction NN cord-015021-pol2qm74 2258 16 zone zone NN cord-015021-pol2qm74 2258 17 by by IN cord-015021-pol2qm74 2258 18 leucocytes leucocytes NNP cord-015021-pol2qm74 2258 19 . . . cord-015021-pol2qm74 2259 1 A. A. NNP cord-015021-pol2qm74 2259 2 Mo Mo NNP cord-015021-pol2qm74 2260 1 ~e ~e NNP cord-015021-pol2qm74 2260 2 ~ ~ NFP cord-015021-pol2qm74 2260 3 o o UH cord-015021-pol2qm74 2260 4 , , , cord-015021-pol2qm74 2260 5 In~.~P in~.~p NN cord-015021-pol2qm74 2260 6 ~ ~ NFP cord-015021-pol2qm74 2260 7 siolo~,D siolo~,D NNP cord-015021-pol2qm74 2260 8 ~ ~ NFP cord-015021-pol2qm74 2260 9 t t NN cord-015021-pol2qm74 2260 10 . . . cord-015021-pol2qm74 2261 1 E~.Cardiolo~,Bogotsolets4 E~.Cardiolo~,Bogotsolets4 NNP cord-015021-pol2qm74 2261 2 , , , cord-015021-pol2qm74 2261 3 ~ev252024 ~ev252024 NNP cord-015021-pol2qm74 2261 4 , , , cord-015021-pol2qm74 2261 5 Ukrmne Ukrmne NNP cord-015021-pol2qm74 2261 6 Systemic Systemic NNP cord-015021-pol2qm74 2262 1 lesion$of lesion$of CC cord-015021-pol2qm74 2262 2 erythron erythron NNP cord-015021-pol2qm74 2262 3 in in IN cord-015021-pol2qm74 2262 4 traumatic traumatic JJ cord-015021-pol2qm74 2262 5 disease disease NN cord-015021-pol2qm74 2262 6 and and CC cord-015021-pol2qm74 2262 7 possibilities possibility NNS cord-015021-pol2qm74 2262 8 of of IN cord-015021-pol2qm74 2262 9 their -PRON- PRP$ cord-015021-pol2qm74 2262 10 regulation regulation NN cord-015021-pol2qm74 2262 11 by by IN cord-015021-pol2qm74 2262 12 opioid opioid JJ cord-015021-pol2qm74 2262 13 peptides peptide NNS cord-015021-pol2qm74 2262 14 . . . cord-015021-pol2qm74 2263 1 Redkin Redkin NNP cord-015021-pol2qm74 2263 2 Y. Y. NNP cord-015021-pol2qm74 2263 3 V. V. NNP cord-015021-pol2qm74 2263 4 , , , cord-015021-pol2qm74 2263 5 Fominih Fominih NNP cord-015021-pol2qm74 2263 6 S. S. NNP cord-015021-pol2qm74 2263 7 G. G. NNP cord-015021-pol2qm74 2264 1 Using use VBG cord-015021-pol2qm74 2264 2 clinical clinical JJ cord-015021-pol2qm74 2264 3 ( ( -LRB- cord-015021-pol2qm74 2264 4 121 121 CD cord-015021-pol2qm74 2264 5 patients patient NNS cord-015021-pol2qm74 2264 6 ) ) -RRB- cord-015021-pol2qm74 2264 7 and and CC cord-015021-pol2qm74 2264 8 experimental experimental JJ cord-015021-pol2qm74 2264 9 material(128 material(128 JJ cord-015021-pol2qm74 2264 10 rats rat NNS cord-015021-pol2qm74 2264 11 and and CC cord-015021-pol2qm74 2264 12 74 74 CD cord-015021-pol2qm74 2264 13 dogs dog NNS cord-015021-pol2qm74 2264 14 ) ) -RRB- cord-015021-pol2qm74 2264 15 we -PRON- PRP cord-015021-pol2qm74 2264 16 revealed reveal VBD cord-015021-pol2qm74 2264 17 general general JJ cord-015021-pol2qm74 2264 18 regularities regularity NNS cord-015021-pol2qm74 2264 19 of of IN cord-015021-pol2qm74 2264 20 erythron erythron NNP cord-015021-pol2qm74 2264 21 lesions lesion NNS cord-015021-pol2qm74 2264 22 after after IN cord-015021-pol2qm74 2264 23 hard hard JJ cord-015021-pol2qm74 2264 24 mechanical mechanical JJ cord-015021-pol2qm74 2264 25 trauma trauma NN cord-015021-pol2qm74 2264 26 of of IN cord-015021-pol2qm74 2264 27 various various JJ cord-015021-pol2qm74 2264 28 genesis genesis NN cord-015021-pol2qm74 2264 29 as as RB cord-015021-pol2qm74 2264 30 well well RB cord-015021-pol2qm74 2264 31 as as IN cord-015021-pol2qm74 2264 32 some some DT cord-015021-pol2qm74 2264 33 mechanisms mechanism NNS cord-015021-pol2qm74 2264 34 of of IN cord-015021-pol2qm74 2264 35 development development NN cord-015021-pol2qm74 2264 36 of of IN cord-015021-pol2qm74 2264 37 posttraumatic posttraumatic JJ cord-015021-pol2qm74 2264 38 anemia anemia NN cord-015021-pol2qm74 2264 39 and and CC cord-015021-pol2qm74 2264 40 possibilities possibility NNS cord-015021-pol2qm74 2264 41 of of IN cord-015021-pol2qm74 2264 42 its -PRON- PRP$ cord-015021-pol2qm74 2264 43 correction correction NN cord-015021-pol2qm74 2264 44 with with IN cord-015021-pol2qm74 2264 45 preparations preparation NNS cord-015021-pol2qm74 2264 46 of of IN cord-015021-pol2qm74 2264 47 opioid opioid JJ cord-015021-pol2qm74 2264 48 peptides peptide NNS cord-015021-pol2qm74 2264 49 . . . cord-015021-pol2qm74 2265 1 The the DT cord-015021-pol2qm74 2265 2 condition condition NN cord-015021-pol2qm74 2265 3 of of IN cord-015021-pol2qm74 2265 4 central central JJ cord-015021-pol2qm74 2265 5 and and CC cord-015021-pol2qm74 2265 6 peripheral peripheral JJ cord-015021-pol2qm74 2265 7 compartments compartment NNS cord-015021-pol2qm74 2265 8 of of IN cord-015021-pol2qm74 2265 9 erythron erythron NNP cord-015021-pol2qm74 2265 10 was be VBD cord-015021-pol2qm74 2265 11 studied study VBN cord-015021-pol2qm74 2265 12 with with IN cord-015021-pol2qm74 2265 13 unified unified JJ cord-015021-pol2qm74 2265 14 morphologic morphologic JJ cord-015021-pol2qm74 2265 15 , , , cord-015021-pol2qm74 2265 16 immunogematological immunogematological JJ cord-015021-pol2qm74 2265 17 , , , cord-015021-pol2qm74 2265 18 biochemical biochemical JJ cord-015021-pol2qm74 2265 19 and and CC cord-015021-pol2qm74 2265 20 radiological radiological JJ cord-015021-pol2qm74 2265 21 methods method NNS cord-015021-pol2qm74 2265 22 . . . cord-015021-pol2qm74 2266 1 It -PRON- PRP cord-015021-pol2qm74 2266 2 was be VBD cord-015021-pol2qm74 2266 3 revealed reveal VBN cord-015021-pol2qm74 2266 4 that that IN cord-015021-pol2qm74 2266 5 irrespective irrespective RB cord-015021-pol2qm74 2266 6 of of IN cord-015021-pol2qm74 2266 7 the the DT cord-015021-pol2qm74 2266 8 experimental experimental JJ cord-015021-pol2qm74 2266 9 animal animal NN cord-015021-pol2qm74 2266 10 species specie NNS cord-015021-pol2qm74 2266 11 ( ( -LRB- cord-015021-pol2qm74 2266 12 dogs dog NNS cord-015021-pol2qm74 2266 13 , , , cord-015021-pol2qm74 2266 14 rats rat NNS cord-015021-pol2qm74 2266 15 ) ) -RRB- cord-015021-pol2qm74 2266 16 or or CC cord-015021-pol2qm74 2266 17 in in IN cord-015021-pol2qm74 2266 18 clinical clinical JJ cord-015021-pol2qm74 2266 19 experiments experiment NNS cord-015021-pol2qm74 2266 20 ( ( -LRB- cord-015021-pol2qm74 2266 21 patients patient NNS cord-015021-pol2qm74 2266 22 ) ) -RRB- cord-015021-pol2qm74 2266 23 and and CC cord-015021-pol2qm74 2266 24 irrespective irrespective RB cord-015021-pol2qm74 2266 25 of of IN cord-015021-pol2qm74 2266 26 the the DT cord-015021-pol2qm74 2266 27 injuring injure VBG cord-015021-pol2qm74 2266 28 factor factor NN cord-015021-pol2qm74 2266 29 type type NN cord-015021-pol2qm74 2266 30 ( ( -LRB- cord-015021-pol2qm74 2266 31 skeletal skeletal JJ cord-015021-pol2qm74 2266 32 trauma trauma NN cord-015021-pol2qm74 2266 33 , , , cord-015021-pol2qm74 2266 34 craniocerebral craniocerebral NNP cord-015021-pol2qm74 2266 35 trauma trauma NN cord-015021-pol2qm74 2266 36 , , , cord-015021-pol2qm74 2266 37 loss loss NN cord-015021-pol2qm74 2266 38 of of IN cord-015021-pol2qm74 2266 39 blood blood NN cord-015021-pol2qm74 2266 40 ) ) -RRB- cord-015021-pol2qm74 2266 41 in in IN cord-015021-pol2qm74 2266 42 erythron erythron NNP cord-015021-pol2qm74 2266 43 can can MD cord-015021-pol2qm74 2266 44 be be VB cord-015021-pol2qm74 2266 45 observed observe VBN cord-015021-pol2qm74 2266 46 one one CD cord-015021-pol2qm74 2266 47 - - HYPH cord-015021-pol2qm74 2266 48 directed direct VBN cord-015021-pol2qm74 2266 49 unspecific unspecific JJ cord-015021-pol2qm74 2266 50 reaction reaction NN cord-015021-pol2qm74 2266 51 realized realize VBN cord-015021-pol2qm74 2266 52 by by IN cord-015021-pol2qm74 2266 53 the the DT cord-015021-pol2qm74 2266 54 considerable considerable JJ cord-015021-pol2qm74 2266 55 lowering lowering NN cord-015021-pol2qm74 2266 56 of of IN cord-015021-pol2qm74 2266 57 hemoglobin hemoglobin NN cord-015021-pol2qm74 2266 58 concentration concentration NN cord-015021-pol2qm74 2266 59 , , , cord-015021-pol2qm74 2266 60 erythrocytes erythrocyte VBZ cord-015021-pol2qm74 2266 61 number number NN cord-015021-pol2qm74 2266 62 and and CC cord-015021-pol2qm74 2266 63 hematocrit hematocrit NN cord-015021-pol2qm74 2266 64 . . . cord-015021-pol2qm74 2267 1 In in IN cord-015021-pol2qm74 2267 2 the the DT cord-015021-pol2qm74 2267 3 initial initial JJ cord-015021-pol2qm74 2267 4 period period NN cord-015021-pol2qm74 2267 5 ( ( -LRB- cord-015021-pol2qm74 2267 6 1 1 CD cord-015021-pol2qm74 2267 7 - - SYM cord-015021-pol2qm74 2267 8 7 7 CD cord-015021-pol2qm74 2267 9 days day NNS cord-015021-pol2qm74 2267 10 ) ) -RRB- cord-015021-pol2qm74 2267 11 in in IN cord-015021-pol2qm74 2267 12 the the DT cord-015021-pol2qm74 2267 13 system system NN cord-015021-pol2qm74 2267 14 of of IN cord-015021-pol2qm74 2267 15 erythron erythron NNP cord-015021-pol2qm74 2267 16 prevail prevail VBP cord-015021-pol2qm74 2267 17 processes process NNS cord-015021-pol2qm74 2267 18 of of IN cord-015021-pol2qm74 2267 19 distraction distraction NN cord-015021-pol2qm74 2267 20 and and CC cord-015021-pol2qm74 2267 21 elimination elimination NN cord-015021-pol2qm74 2267 22 of of IN cord-015021-pol2qm74 2267 23 er er UH cord-015021-pol2qm74 2267 24 ~ ~ NFP cord-015021-pol2qm74 2267 25 zthrocytes zthrocytes XX cord-015021-pol2qm74 2267 26 relatively relatively RB cord-015021-pol2qm74 2267 27 to to IN cord-015021-pol2qm74 2267 28 the the DT cord-015021-pol2qm74 2267 29 general general JJ cord-015021-pol2qm74 2267 30 production production NN cord-015021-pol2qm74 2267 31 of of IN cord-015021-pol2qm74 2267 32 stimulated stimulate VBN cord-015021-pol2qm74 2267 33 erythropoiesis erythropoiesis NN cord-015021-pol2qm74 2267 34 . . . cord-015021-pol2qm74 2268 1 The the DT cord-015021-pol2qm74 2268 2 primary primary JJ cord-015021-pol2qm74 2268 3 alterating alterating NN cord-015021-pol2qm74 2268 4 factor factor NN cord-015021-pol2qm74 2268 5 is be VBZ cord-015021-pol2qm74 2268 6 the the DT cord-015021-pol2qm74 2268 7 prolonged prolonged JJ cord-015021-pol2qm74 2268 8 intensification intensification NN cord-015021-pol2qm74 2268 9 of of IN cord-015021-pol2qm74 2268 10 peroxydation peroxydation NN cord-015021-pol2qm74 2268 11 of of IN cord-015021-pol2qm74 2268 12 membrane membrane NN cord-015021-pol2qm74 2268 13 iipids iipid NNS cord-015021-pol2qm74 2268 14 of of IN cord-015021-pol2qm74 2268 15 erythrocytes erythrocyte NNS cord-015021-pol2qm74 2268 16 with with IN cord-015021-pol2qm74 2268 17 simultaneous simultaneous JJ cord-015021-pol2qm74 2268 18 lowering lowering NN cord-015021-pol2qm74 2268 19 of of IN cord-015021-pol2qm74 2268 20 reserves reserve NNS cord-015021-pol2qm74 2268 21 of of IN cord-015021-pol2qm74 2268 22 reduced reduce VBN cord-015021-pol2qm74 2268 23 glutathione glutathione NN cord-015021-pol2qm74 2268 24 . . . cord-015021-pol2qm74 2269 1 The the DT cord-015021-pol2qm74 2269 2 distraction distraction NN cord-015021-pol2qm74 2269 3 of of IN cord-015021-pol2qm74 2269 4 erythrocytes erythrocyte NNS cord-015021-pol2qm74 2269 5 is be VBZ cord-015021-pol2qm74 2269 6 supported support VBN cord-015021-pol2qm74 2269 7 by by IN cord-015021-pol2qm74 2269 8 the the DT cord-015021-pol2qm74 2269 9 developing develop VBG cord-015021-pol2qm74 2269 10 phenomena phenomenon NNS cord-015021-pol2qm74 2269 11 of of IN cord-015021-pol2qm74 2269 12 autoallergization autoallergization NN cord-015021-pol2qm74 2269 13 of of IN cord-015021-pol2qm74 2269 14 organism organism NN cord-015021-pol2qm74 2269 15 that that WDT cord-015021-pol2qm74 2269 16 becomes become VBZ cord-015021-pol2qm74 2269 17 apparent apparent JJ cord-015021-pol2qm74 2269 18 by by IN cord-015021-pol2qm74 2269 19 the the DT cord-015021-pol2qm74 2269 20 appearance appearance NN cord-015021-pol2qm74 2269 21 of of IN cord-015021-pol2qm74 2269 22 sensitized sensitize VBN cord-015021-pol2qm74 2269 23 T T NNP cord-015021-pol2qm74 2269 24 cells cell NNS cord-015021-pol2qm74 2269 25 and and CC cord-015021-pol2qm74 2269 26 antierythrocyte antierythrocyte NNP cord-015021-pol2qm74 2269 27 antibodies antibody NNS cord-015021-pol2qm74 2269 28 . . . cord-015021-pol2qm74 2270 1 The the DT cord-015021-pol2qm74 2270 2 intensified intensify VBN cord-015021-pol2qm74 2270 3 production production NN cord-015021-pol2qm74 2270 4 of of IN cord-015021-pol2qm74 2270 5 erythropoietin erythropoietin NN cord-015021-pol2qm74 2270 6 rules rule NNS cord-015021-pol2qm74 2270 7 to to IN cord-015021-pol2qm74 2270 8 the the DT cord-015021-pol2qm74 2270 9 realization realization NN cord-015021-pol2qm74 2270 10 of of IN cord-015021-pol2qm74 2270 11 he -PRON- PRP cord-015021-pol2qm74 2270 12 program program NN cord-015021-pol2qm74 2270 13 of of IN cord-015021-pol2qm74 2270 14 fetal fetal JJ cord-015021-pol2qm74 2270 15 and and CC cord-015021-pol2qm74 2270 16 terminal terminal JJ cord-015021-pol2qm74 2270 17 ( ( -LRB- cord-015021-pol2qm74 2270 18 reserved reserved JJ cord-015021-pol2qm74 2270 19 ) ) -RRB- cord-015021-pol2qm74 2270 20 erythropoiesis erythropoiesis NN cord-015021-pol2qm74 2270 21 . . . cord-015021-pol2qm74 2271 1 Failure failure NN cord-015021-pol2qm74 2271 2 of of IN cord-015021-pol2qm74 2271 3 erythropoiesis erythropoiesis NN cord-015021-pol2qm74 2271 4 function function NN cord-015021-pol2qm74 2271 5 is be VBZ cord-015021-pol2qm74 2271 6 supported support VBN cord-015021-pol2qm74 2271 7 by by IN cord-015021-pol2qm74 2271 8 disturbances disturbance NNS cord-015021-pol2qm74 2271 9 of of IN cord-015021-pol2qm74 2271 10 the the DT cord-015021-pol2qm74 2271 11 processes process NNS cord-015021-pol2qm74 2271 12 of of IN cord-015021-pol2qm74 2271 13 the the DT cord-015021-pol2qm74 2271 14 injuring injuring NN cord-015021-pol2qm74 2271 15 of of IN cord-015021-pol2qm74 2271 16 cell cell NN cord-015021-pol2qm74 2271 17 metabolic metabolic JJ cord-015021-pol2qm74 2271 18 apparatus apparatus NN cord-015021-pol2qm74 2271 19 . . . cord-015021-pol2qm74 2272 1 Using use VBG cord-015021-pol2qm74 2272 2 of of IN cord-015021-pol2qm74 2272 3 dalargin dalargin NNP cord-015021-pol2qm74 2272 4 ( ( -LRB- cord-015021-pol2qm74 2272 5 15 15 CD cord-015021-pol2qm74 2272 6 microgram microgram NN cord-015021-pol2qm74 2272 7 per per IN cord-015021-pol2qm74 2272 8 kilogram kilogram NN cord-015021-pol2qm74 2272 9 of of IN cord-015021-pol2qm74 2272 10 body body NN cord-015021-pol2qm74 2272 11 mass mass NN cord-015021-pol2qm74 2272 12 intrap'eritoneally intrap'eritoneally NN cord-015021-pol2qm74 2272 13 within within IN cord-015021-pol2qm74 2272 14 5 5 CD cord-015021-pol2qm74 2272 15 days day NNS cord-015021-pol2qm74 2272 16 after after IN cord-015021-pol2qm74 2272 17 the the DT cord-015021-pol2qm74 2272 18 trauma trauma NN cord-015021-pol2qm74 2272 19 ) ) -RRB- cord-015021-pol2qm74 2272 20 showed show VBD cord-015021-pol2qm74 2272 21 the the DT cord-015021-pol2qm74 2272 22 precise precise JJ cord-015021-pol2qm74 2272 23 pharmacotherapeutic pharmacotherapeutic JJ cord-015021-pol2qm74 2272 24 effect effect NN cord-015021-pol2qm74 2272 25 revealed reveal VBN cord-015021-pol2qm74 2272 26 by by IN cord-015021-pol2qm74 2272 27 the the DT cord-015021-pol2qm74 2272 28 diminishing diminishing NN cord-015021-pol2qm74 2272 29 of of IN cord-015021-pol2qm74 2272 30 anemia anemia NN cord-015021-pol2qm74 2272 31 of of IN cord-015021-pol2qm74 2272 32 experimental experimental JJ cord-015021-pol2qm74 2272 33 rats rat NNS cord-015021-pol2qm74 2272 34 , , , cord-015021-pol2qm74 2272 35 more more JJR cord-015021-pol2qm74 2272 36 . . . cord-015021-pol2qm74 2273 1 Fiberbronohoscopic Fiberbronohoscopic NNP cord-015021-pol2qm74 2273 2 procedures procedure NNS cord-015021-pol2qm74 2273 3 are be VBP cord-015021-pol2qm74 2273 4 known know VBN cord-015021-pol2qm74 2273 5 to to TO cord-015021-pol2qm74 2273 6 produce produce VB cord-015021-pol2qm74 2273 7 " " `` cord-015021-pol2qm74 2273 8 PEEP peep NN cord-015021-pol2qm74 2273 9 - - HYPH cord-015021-pol2qm74 2273 10 like like JJ cord-015021-pol2qm74 2273 11 " " `` cord-015021-pol2qm74 2273 12 effects effect NNS cord-015021-pol2qm74 2273 13 and and CC cord-015021-pol2qm74 2273 14 to to TO cord-015021-pol2qm74 2273 15 increase increase VB cord-015021-pol2qm74 2273 16 pulmonary pulmonary JJ cord-015021-pol2qm74 2273 17 artery artery NN cord-015021-pol2qm74 2273 18 ( ( -LRB- cord-015021-pol2qm74 2273 19 PA PA NNP cord-015021-pol2qm74 2273 20 ) ) -RRB- cord-015021-pol2qm74 2273 21 resistance resistance NN cord-015021-pol2qm74 2273 22 [ [ -LRB- cord-015021-pol2qm74 2273 23 2 2 CD cord-015021-pol2qm74 2273 24 ] ] -RRB- cord-015021-pol2qm74 2273 25 . . . cord-015021-pol2qm74 2274 1 PEEP PEEP NNP cord-015021-pol2qm74 2274 2 can can MD cord-015021-pol2qm74 2274 3 affect affect VB cord-015021-pol2qm74 2274 4 RV RV NNP cord-015021-pol2qm74 2274 5 function function NN cord-015021-pol2qm74 2274 6 by by IN cord-015021-pol2qm74 2274 7 reducing reduce VBG cord-015021-pol2qm74 2274 8 preload preload NN cord-015021-pol2qm74 2274 9 and and CC cord-015021-pol2qm74 2274 10 ejection ejection NN cord-015021-pol2qm74 2274 11 fraction fraction NN cord-015021-pol2qm74 2274 12 ( ( -LRB- cord-015021-pol2qm74 2274 13 EF EF NNP cord-015021-pol2qm74 2274 14 ) ) -RRB- cord-015021-pol2qm74 2274 15 [ [ -LRB- cord-015021-pol2qm74 2274 16 3 3 CD cord-015021-pol2qm74 2274 17 ] ] -RRB- cord-015021-pol2qm74 2274 18 . . . cord-015021-pol2qm74 2275 1 Since since IN cord-015021-pol2qm74 2275 2 changes change NNS cord-015021-pol2qm74 2275 3 of of IN cord-015021-pol2qm74 2275 4 RV RV NNP cord-015021-pol2qm74 2275 5 function function NN cord-015021-pol2qm74 2275 6 during during IN cord-015021-pol2qm74 2275 7 bronchoscopy bronchoscopy NN cord-015021-pol2qm74 2275 8 in in IN cord-015021-pol2qm74 2275 9 septic septic JJ cord-015021-pol2qm74 2275 10 patients patient NNS cord-015021-pol2qm74 2275 11 are be VBP cord-015021-pol2qm74 2275 12 not not RB cord-015021-pol2qm74 2275 13 reported report VBN cord-015021-pol2qm74 2275 14 , , , cord-015021-pol2qm74 2275 15 we -PRON- PRP cord-015021-pol2qm74 2275 16 measured measure VBD cord-015021-pol2qm74 2275 17 RV RV NNP cord-015021-pol2qm74 2275 18 parameters parameter NNS cord-015021-pol2qm74 2275 19 before before RB cord-015021-pol2qm74 2275 20 , , , cord-015021-pol2qm74 2275 21 during during IN cord-015021-pol2qm74 2275 22 and and CC cord-015021-pol2qm74 2275 23 after after IN cord-015021-pol2qm74 2275 24 fiberoptic fiberoptic JJ cord-015021-pol2qm74 2275 25 bronchoalveolar bronchoalveolar NNP cord-015021-pol2qm74 2275 26 lavage lavage NN cord-015021-pol2qm74 2275 27 ( ( -LRB- cord-015021-pol2qm74 2275 28 BAL BAL NNP cord-015021-pol2qm74 2275 29 ) ) -RRB- cord-015021-pol2qm74 2275 30 . . . cord-015021-pol2qm74 2276 1 Method method NN cord-015021-pol2qm74 2276 2 : : : cord-015021-pol2qm74 2277 1 This this DT cord-015021-pol2qm74 2277 2 34-year 34-year JJ cord-015021-pol2qm74 2277 3 - - HYPH cord-015021-pol2qm74 2277 4 old old JJ cord-015021-pol2qm74 2277 5 patient patient NN cord-015021-pol2qm74 2277 6 ( ( -LRB- cord-015021-pol2qm74 2277 7 APACHE APACHE NNP cord-015021-pol2qm74 2277 8 - - HYPH cord-015021-pol2qm74 2277 9 II:24 II:24 NNP cord-015021-pol2qm74 2277 10 ) ) -RRB- cord-015021-pol2qm74 2277 11 developed develop VBD cord-015021-pol2qm74 2277 12 a a DT cord-015021-pol2qm74 2277 13 hyperdynanlic hyperdynanlic JJ cord-015021-pol2qm74 2277 14 septic septic JJ cord-015021-pol2qm74 2277 15 state state NN cord-015021-pol2qm74 2277 16 due due JJ cord-015021-pol2qm74 2277 17 to to IN cord-015021-pol2qm74 2277 18 Staphylococcus Staphylococcus NNP cord-015021-pol2qm74 2277 19 aureus aureus NN cord-015021-pol2qm74 2277 20 ( ( -LRB- cord-015021-pol2qm74 2277 21 blood blood NN cord-015021-pol2qm74 2277 22 culture culture NN cord-015021-pol2qm74 2277 23 ) ) -RRB- cord-015021-pol2qm74 2277 24 . . . cord-015021-pol2qm74 2278 1 We -PRON- PRP cord-015021-pol2qm74 2278 2 inserted insert VBD cord-015021-pol2qm74 2278 3 a a DT cord-015021-pol2qm74 2278 4 " " `` cord-015021-pol2qm74 2278 5 fast fast JJ cord-015021-pol2qm74 2278 6 response response NN cord-015021-pol2qm74 2278 7 " " '' cord-015021-pol2qm74 2278 8 thermistor thermistor NN cord-015021-pol2qm74 2278 9 PA PA NNP cord-015021-pol2qm74 2278 10 - - HYPH cord-015021-pol2qm74 2278 11 catheter catheter NNP cord-015021-pol2qm74 2278 12 ( ( -LRB- cord-015021-pol2qm74 2278 13 Baxter Baxter NNP cord-015021-pol2qm74 2278 14 - - HYPH cord-015021-pol2qm74 2278 15 Edwards Edwards NNP cord-015021-pol2qm74 2278 16 ) ) -RRB- cord-015021-pol2qm74 2278 17 to to TO cord-015021-pol2qm74 2278 18 evaluate evaluate VB cord-015021-pol2qm74 2278 19 RV rv NN cord-015021-pol2qm74 2278 20 performance performance NN cord-015021-pol2qm74 2278 21 [ [ -LRB- cord-015021-pol2qm74 2278 22 4 4 CD cord-015021-pol2qm74 2278 23 ] ] -RRB- cord-015021-pol2qm74 2278 24 . . . cord-015021-pol2qm74 2279 1 The the DT cord-015021-pol2qm74 2279 2 therapeutic therapeutic JJ cord-015021-pol2qm74 2279 3 procedure procedure NN cord-015021-pol2qm74 2279 4 included include VBD cord-015021-pol2qm74 2279 5 volume volume NN cord-015021-pol2qm74 2279 6 replacement replacement NN cord-015021-pol2qm74 2279 7 , , , cord-015021-pol2qm74 2279 8 vasopressors vasopressor NNS cord-015021-pol2qm74 2279 9 ( ( -LRB- cord-015021-pol2qm74 2279 10 dopamine dopamine NN cord-015021-pol2qm74 2279 11 5 5 CD cord-015021-pol2qm74 2279 12 , , , cord-015021-pol2qm74 2279 13 dobutamine dobutamine NNP cord-015021-pol2qm74 2279 14 3 3 CD cord-015021-pol2qm74 2279 15 gg gg NNP cord-015021-pol2qm74 2279 16 / / SYM cord-015021-pol2qm74 2279 17 kg kg NNP cord-015021-pol2qm74 2279 18 / / SYM cord-015021-pol2qm74 2279 19 min min NN cord-015021-pol2qm74 2279 20 . . . cord-015021-pol2qm74 2279 21 IV IV NNP cord-015021-pol2qm74 2279 22 ) ) -RRB- cord-015021-pol2qm74 2279 23 and and CC cord-015021-pol2qm74 2280 1 analgosedatior/. analgosedatior/. CC cord-015021-pol2qm74 2280 2 Before before IN cord-015021-pol2qm74 2280 3 bronchoscopy bronchoscopy NN cord-015021-pol2qm74 2280 4 ( ( -LRB- cord-015021-pol2qm74 2280 5 Olympus Olympus NNP cord-015021-pol2qm74 2280 6 BF-30 BF-30 NNP cord-015021-pol2qm74 2280 7 , , , cord-015021-pol2qm74 2280 8 OD=6 OD=6 NNP cord-015021-pol2qm74 2280 9 mm mm NNP cord-015021-pol2qm74 2280 10 ) ) -RRB- cord-015021-pol2qm74 2280 11 the the DT cord-015021-pol2qm74 2280 12 patient patient NN cord-015021-pol2qm74 2280 13 received receive VBD cord-015021-pol2qm74 2280 14 pancmonium pancmonium NN cord-015021-pol2qm74 2280 15 for for IN cord-015021-pol2qm74 2280 16 muscle muscle NN cord-015021-pol2qm74 2280 17 relaxation relaxation NN cord-015021-pol2qm74 2280 18 . . . cord-015021-pol2qm74 2281 1 Ventilation ventilation NN cord-015021-pol2qm74 2281 2 was be VBD cord-015021-pol2qm74 2281 3 not not RB cord-015021-pol2qm74 2281 4 changed change VBN cord-015021-pol2qm74 2281 5 during during IN cord-015021-pol2qm74 2281 6 the the DT cord-015021-pol2qm74 2281 7 procedure procedure NN cord-015021-pol2qm74 2281 8 ( ( -LRB- cord-015021-pol2qm74 2281 9 endotracheal endotracheal NN cord-015021-pol2qm74 2281 10 tube tube NN cord-015021-pol2qm74 2281 11 : : : cord-015021-pol2qm74 2281 12 ID=8 id=8 NN cord-015021-pol2qm74 2281 13 ram ram NN cord-015021-pol2qm74 2281 14 , , , cord-015021-pol2qm74 2281 15 Bennett Bennett NNP cord-015021-pol2qm74 2281 16 7200a 7200a CD cord-015021-pol2qm74 2281 17 , , , cord-015021-pol2qm74 2281 18 pressure pressure NN cord-015021-pol2qm74 2281 19 controlled control VBN cord-015021-pol2qm74 2281 20 mode mode NN cord-015021-pol2qm74 2281 21 , , , cord-015021-pol2qm74 2282 1 Pm pm NN cord-015021-pol2qm74 2282 2 ~ ~ CD cord-015021-pol2qm74 2282 3 x=25 x=25 NN cord-015021-pol2qm74 2282 4 mbar mbar NN cord-015021-pol2qm74 2282 5 , , , cord-015021-pol2qm74 2282 6 PEEP=8 peep=8 NN cord-015021-pol2qm74 2282 7 mbar mbar NN cord-015021-pol2qm74 2282 8 , , , cord-015021-pol2qm74 2282 9 I i NN cord-015021-pol2qm74 2282 10 : : : cord-015021-pol2qm74 2282 11 E e NN cord-015021-pol2qm74 2282 12 = = NN cord-015021-pol2qm74 2282 13 I i NN cord-015021-pol2qm74 2282 14 : : : cord-015021-pol2qm74 2282 15 I -PRON- PRP cord-015021-pol2qm74 2282 16 , , , cord-015021-pol2qm74 2282 17 FiO2=1.0 FiO2=1.0 NNP cord-015021-pol2qm74 2282 18 ) ) -RRB- cord-015021-pol2qm74 2282 19 . . . cord-015021-pol2qm74 2283 1 We -PRON- PRP cord-015021-pol2qm74 2283 2 measured measure VBD cord-015021-pol2qm74 2283 3 RV RV NNP cord-015021-pol2qm74 2283 4 enddiastolic enddiastolic NN cord-015021-pol2qm74 2283 5 volume volume NN cord-015021-pol2qm74 2283 6 ( ( -LRB- cord-015021-pol2qm74 2283 7 EDV EDV NNP cord-015021-pol2qm74 2283 8 ) ) -RRB- cord-015021-pol2qm74 2283 9 , , , cord-015021-pol2qm74 2283 10 stroke stroke NN cord-015021-pol2qm74 2283 11 volume volume NN cord-015021-pol2qm74 2283 12 ( ( -LRB- cord-015021-pol2qm74 2283 13 SV SV NNP cord-015021-pol2qm74 2283 14 ) ) -RRB- cord-015021-pol2qm74 2283 15 , , , cord-015021-pol2qm74 2283 16 EF EF NNP cord-015021-pol2qm74 2283 17 , , , cord-015021-pol2qm74 2283 18 heart heart NN cord-015021-pol2qm74 2283 19 rate rate NN cord-015021-pol2qm74 2283 20 ( ( -LRB- cord-015021-pol2qm74 2283 21 HR HR NNP cord-015021-pol2qm74 2283 22 ) ) -RRB- cord-015021-pol2qm74 2283 23 , , . cord-015021-pol2qm74 2284 1 cardiac cardiac JJ cord-015021-pol2qm74 2284 2 index index NN cord-015021-pol2qm74 2284 3 ( ( -LRB- cord-015021-pol2qm74 2284 4 CI CI NNP cord-015021-pol2qm74 2284 5 ) ) -RRB- cord-015021-pol2qm74 2284 6 and and CC cord-015021-pol2qm74 2284 7 mean mean VB cord-015021-pol2qm74 2284 8 PA PA NNP cord-015021-pol2qm74 2284 9 pressure pressure NN cord-015021-pol2qm74 2284 10 ( ( -LRB- cord-015021-pol2qm74 2284 11 MPAP MPAP NNP cord-015021-pol2qm74 2284 12 Gerlach Gerlach NNP cord-015021-pol2qm74 2284 13 H H NNP cord-015021-pol2qm74 2284 14 , , , cord-015021-pol2qm74 2284 15 Gerlach Gerlach NNP cord-015021-pol2qm74 2284 16 M M NNP cord-015021-pol2qm74 2284 17 , , , cord-015021-pol2qm74 2284 18 Clauss Clauss NNP cord-015021-pol2qm74 2284 19 M M NNP cord-015021-pol2qm74 2284 20 , , , cord-015021-pol2qm74 2284 21 Falke Falke NNP cord-015021-pol2qm74 2284 22 KJ KJ NNP cord-015021-pol2qm74 2284 23 Renal renal JJ cord-015021-pol2qm74 2284 24 hypoxia hypoxia NN cord-015021-pol2qm74 2284 25 and/or and/or CC cord-015021-pol2qm74 2284 26 ischemia ischemia NN cord-015021-pol2qm74 2284 27 initiates initiate VBZ cord-015021-pol2qm74 2284 28 the the DT cord-015021-pol2qm74 2284 29 development development NN cord-015021-pol2qm74 2284 30 of of IN cord-015021-pol2qm74 2284 31 a a DT cord-015021-pol2qm74 2284 32 deteriorated deteriorate VBN cord-015021-pol2qm74 2284 33 medullary medullary JJ cord-015021-pol2qm74 2284 34 perfusion perfusion NN cord-015021-pol2qm74 2284 35 based base VBN cord-015021-pol2qm74 2284 36 on on IN cord-015021-pol2qm74 2284 37 fibrin fibrin NN cord-015021-pol2qm74 2284 38 deposition deposition NN cord-015021-pol2qm74 2284 39 in in IN cord-015021-pol2qm74 2284 40 the the DT cord-015021-pol2qm74 2284 41 peritubular peritubular JJ cord-015021-pol2qm74 2284 42 capillaries capillary NNS cord-015021-pol2qm74 2284 43 , , , cord-015021-pol2qm74 2284 44 vasoconstriction vasoconstriction NN cord-015021-pol2qm74 2284 45 , , , cord-015021-pol2qm74 2284 46 and and CC cord-015021-pol2qm74 2284 47 perivascular perivascular JJ cord-015021-pol2qm74 2284 48 edema edema NN cord-015021-pol2qm74 2284 49 , , , cord-015021-pol2qm74 2284 50 which which WDT cord-015021-pol2qm74 2284 51 is be VBZ cord-015021-pol2qm74 2284 52 followed follow VBN cord-015021-pol2qm74 2284 53 by by IN cord-015021-pol2qm74 2284 54 a a DT cord-015021-pol2qm74 2284 55 swelling swelling NN cord-015021-pol2qm74 2284 56 of of IN cord-015021-pol2qm74 2284 57 the the DT cord-015021-pol2qm74 2284 58 tubular tubular JJ cord-015021-pol2qm74 2284 59 epithelial epithelial JJ cord-015021-pol2qm74 2284 60 ceils ceil NNS cord-015021-pol2qm74 2284 61 , , , cord-015021-pol2qm74 2284 62 intraluminal intraluminal JJ cord-015021-pol2qm74 2284 63 tubular tubular JJ cord-015021-pol2qm74 2284 64 obstruction obstruction NN cord-015021-pol2qm74 2284 65 , , , cord-015021-pol2qm74 2284 66 and and CC cord-015021-pol2qm74 2284 67 a a DT cord-015021-pol2qm74 2284 68 backleak backleak NN cord-015021-pol2qm74 2284 69 of of IN cord-015021-pol2qm74 2284 70 fluid fluid NN cord-015021-pol2qm74 2284 71 through through IN cord-015021-pol2qm74 2284 72 the the DT cord-015021-pol2qm74 2284 73 injured injure VBN cord-015021-pol2qm74 2284 74 tubules tubule NNS cord-015021-pol2qm74 2284 75 into into IN cord-015021-pol2qm74 2284 76 the the DT cord-015021-pol2qm74 2284 77 renal renal JJ cord-015021-pol2qm74 2284 78 interstitium interstitium NN cord-015021-pol2qm74 2284 79 , , , cord-015021-pol2qm74 2284 80 finally finally RB cord-015021-pol2qm74 2284 81 leading lead VBG cord-015021-pol2qm74 2284 82 to to IN cord-015021-pol2qm74 2284 83 an an DT cord-015021-pol2qm74 2284 84 acute acute JJ cord-015021-pol2qm74 2284 85 tubular tubular JJ cord-015021-pol2qm74 2284 86 necrosis necrosis NN cord-015021-pol2qm74 2284 87 ( ( -LRB- cord-015021-pol2qm74 2284 88 ATN ATN NNP cord-015021-pol2qm74 2284 89 ) ) -RRB- cord-015021-pol2qm74 2284 90 [ [ -LRB- cord-015021-pol2qm74 2284 91 1 1 CD cord-015021-pol2qm74 2284 92 ] ] -RRB- cord-015021-pol2qm74 2284 93 , , , cord-015021-pol2qm74 2284 94 clinically clinically RB cord-015021-pol2qm74 2284 95 diagnosed diagnose VBN cord-015021-pol2qm74 2284 96 as as IN cord-015021-pol2qm74 2284 97 acute acute JJ cord-015021-pol2qm74 2284 98 renal renal JJ cord-015021-pol2qm74 2284 99 failure failure NN cord-015021-pol2qm74 2284 100 ( ( -LRB- cord-015021-pol2qm74 2284 101 ARF ARF NNP cord-015021-pol2qm74 2284 102 ) ) -RRB- cord-015021-pol2qm74 2284 103 . . . cord-015021-pol2qm74 2285 1 One one CD cord-015021-pol2qm74 2285 2 important important JJ cord-015021-pol2qm74 2285 3 pathway pathway NN cord-015021-pol2qm74 2285 4 for for IN cord-015021-pol2qm74 2285 5 induction induction NN cord-015021-pol2qm74 2285 6 of of IN cord-015021-pol2qm74 2285 7 enhanced enhanced JJ cord-015021-pol2qm74 2285 8 vascular vascular JJ cord-015021-pol2qm74 2285 9 procoagulant procoagulant JJ cord-015021-pol2qm74 2285 10 activity activity NN cord-015021-pol2qm74 2285 11 and and CC cord-015021-pol2qm74 2285 12 permeability permeability NN cord-015021-pol2qm74 2285 13 is be VBZ cord-015021-pol2qm74 2285 14 based base VBN cord-015021-pol2qm74 2285 15 on on IN cord-015021-pol2qm74 2285 16 the the DT cord-015021-pol2qm74 2285 17 synthesis synthesis NN cord-015021-pol2qm74 2285 18 and and CC cord-015021-pol2qm74 2285 19 expression expression NN cord-015021-pol2qm74 2285 20 of of IN cord-015021-pol2qm74 2285 21 macrophage macrophage NN cord-015021-pol2qm74 2285 22 - - HYPH cord-015021-pol2qm74 2285 23 derived derive VBN cord-015021-pol2qm74 2285 24 cytokines cytokine NNS cord-015021-pol2qm74 2285 25 , , , cord-015021-pol2qm74 2285 26 which which WDT cord-015021-pol2qm74 2285 27 bind bind VBP cord-015021-pol2qm74 2285 28 to to IN cord-015021-pol2qm74 2285 29 specific specific JJ cord-015021-pol2qm74 2285 30 endothelial endothelial JJ cord-015021-pol2qm74 2285 31 cell cell NN cord-015021-pol2qm74 2285 32 surface surface NN cord-015021-pol2qm74 2285 33 receptors receptor NNS cord-015021-pol2qm74 2285 34 . . . cord-015021-pol2qm74 2286 1 We -PRON- PRP cord-015021-pol2qm74 2286 2 recently recently RB cord-015021-pol2qm74 2286 3 described describe VBD cord-015021-pol2qm74 2286 4 the the DT cord-015021-pol2qm74 2286 5 identification identification NN cord-015021-pol2qm74 2286 6 and and CC cord-015021-pol2qm74 2286 7 purification purification NN cord-015021-pol2qm74 2286 8 .of .of . cord-015021-pol2qm74 2287 1 a a DT cord-015021-pol2qm74 2287 2 new new JJ cord-015021-pol2qm74 2287 3 55,000 55,000 CD cord-015021-pol2qm74 2287 4 Dalton Dalton NNP cord-015021-pol2qm74 2287 5 polypeptide polypeptide NN cord-015021-pol2qm74 2287 6 , , , cord-015021-pol2qm74 2287 7 which which WDT cord-015021-pol2qm74 2287 8 is be VBZ cord-015021-pol2qm74 2287 9 synthesized synthesize VBN cord-015021-pol2qm74 2287 10 and and CC cord-015021-pol2qm74 2287 11 expressed express VBN cord-015021-pol2qm74 2287 12 by by IN cord-015021-pol2qm74 2287 13 murine murine JJ cord-015021-pol2qm74 2287 14 macrophages macrophage NNS cord-015021-pol2qm74 2287 15 after after IN cord-015021-pol2qm74 2287 16 stimulation stimulation NN cord-015021-pol2qm74 2287 17 with with IN cord-015021-pol2qm74 2287 18 lipopolysaccharide lipopolysaccharide NN cord-015021-pol2qm74 2287 19 , , , cord-015021-pol2qm74 2287 20 and and CC cord-015021-pol2qm74 2287 21 exerts exert VBZ cord-015021-pol2qm74 2287 22 procoagulant procoagulant JJ cord-015021-pol2qm74 2287 23 activity activity NN cord-015021-pol2qm74 2287 24 on on IN cord-015021-pol2qm74 2287 25 cultured cultured JJ cord-015021-pol2qm74 2287 26 endothelial endothelial JJ cord-015021-pol2qm74 2287 27 cells cell NNS cord-015021-pol2qm74 2287 28 [ [ -LRB- cord-015021-pol2qm74 2287 29 2 2 CD cord-015021-pol2qm74 2287 30 ] ] -RRB- cord-015021-pol2qm74 2287 31 . . . cord-015021-pol2qm74 2288 1 In in IN cord-015021-pol2qm74 2288 2 the the DT cord-015021-pol2qm74 2288 3 presented present VBN cord-015021-pol2qm74 2288 4 study study NN cord-015021-pol2qm74 2288 5 , , , cord-015021-pol2qm74 2288 6 we -PRON- PRP cord-015021-pol2qm74 2288 7 demonstrate demonstrate VBP cord-015021-pol2qm74 2288 8 that that IN cord-015021-pol2qm74 2288 9 the the DT cord-015021-pol2qm74 2288 10 new new JJ cord-015021-pol2qm74 2288 11 polypeptid polypeptid NN cord-015021-pol2qm74 2288 12 is be VBZ cord-015021-pol2qm74 2288 13 also also RB cord-015021-pol2qm74 2288 14 synthesized synthesize VBN cord-015021-pol2qm74 2288 15 by by IN cord-015021-pol2qm74 2288 16 macrophages macrophage NNS cord-015021-pol2qm74 2288 17 under under IN cord-015021-pol2qm74 2288 18 hypoxic hypoxic JJ cord-015021-pol2qm74 2288 19 conditions condition NNS cord-015021-pol2qm74 2288 20 . . . cord-015021-pol2qm74 2289 1 The the DT cord-015021-pol2qm74 2289 2 protein protein NN cord-015021-pol2qm74 2289 3 binds bind VBZ cord-015021-pol2qm74 2289 4 to to IN cord-015021-pol2qm74 2289 5 specific specific JJ cord-015021-pol2qm74 2289 6 receptors receptor NNS cord-015021-pol2qm74 2289 7 , , , cord-015021-pol2qm74 2289 8 which which WDT cord-015021-pol2qm74 2289 9 are be VBP cord-015021-pol2qm74 2289 10 expressed express VBN cord-015021-pol2qm74 2289 11 by by IN cord-015021-pol2qm74 2289 12 endothelial endothelial JJ cord-015021-pol2qm74 2289 13 cells cell NNS cord-015021-pol2qm74 2289 14 dependent dependent JJ cord-015021-pol2qm74 2289 15 on on IN cord-015021-pol2qm74 2289 16 the the DT cord-015021-pol2qm74 2289 17 environmental environmental JJ cord-015021-pol2qm74 2289 18 oxygen oxygen NN cord-015021-pol2qm74 2289 19 tension tension NN cord-015021-pol2qm74 2289 20 . . . cord-015021-pol2qm74 2290 1 Animal animal NN cord-015021-pol2qm74 2290 2 studies study NNS cord-015021-pol2qm74 2290 3 were be VBD cord-015021-pol2qm74 2290 4 performed perform VBN cord-015021-pol2qm74 2290 5 after after IN cord-015021-pol2qm74 2290 6 approval approval NN cord-015021-pol2qm74 2290 7 by by IN cord-015021-pol2qm74 2290 8 the the DT cord-015021-pol2qm74 2290 9 local local JJ cord-015021-pol2qm74 2290 10 committee committee NN cord-015021-pol2qm74 2290 11 for for IN cord-015021-pol2qm74 2290 12 animal animal NNP cord-015021-pol2qm74 2290 13 safety safety NN cord-015021-pol2qm74 2290 14 ; ; : cord-015021-pol2qm74 2290 15 the the DT cord-015021-pol2qm74 2290 16 animals animal NNS cord-015021-pol2qm74 2290 17 were be VBD cord-015021-pol2qm74 2290 18 anesthetized anesthetize VBN cord-015021-pol2qm74 2290 19 , , , cord-015021-pol2qm74 2290 20 treated treat VBN cord-015021-pol2qm74 2290 21 and and CC cord-015021-pol2qm74 2290 22 supervised supervise VBN cord-015021-pol2qm74 2290 23 in in IN cord-015021-pol2qm74 2290 24 accordance accordance NN cord-015021-pol2qm74 2290 25 with with IN cord-015021-pol2qm74 2290 26 the the DT cord-015021-pol2qm74 2290 27 guidelines guideline NNS cord-015021-pol2qm74 2290 28 of of IN cord-015021-pol2qm74 2290 29 this this DT cord-015021-pol2qm74 2290 30 committee committee NN cord-015021-pol2qm74 2290 31 . . . cord-015021-pol2qm74 2291 1 In in IN cord-015021-pol2qm74 2291 2 contrast contrast NN cord-015021-pol2qm74 2291 3 to to IN cord-015021-pol2qm74 2291 4 other other JJ cord-015021-pol2qm74 2291 5 authors author NNS cord-015021-pol2qm74 2291 6 , , , cord-015021-pol2qm74 2291 7 who who WP cord-015021-pol2qm74 2291 8 performed perform VBD cord-015021-pol2qm74 2291 9 long long JJ cord-015021-pol2qm74 2291 10 - - HYPH cord-015021-pol2qm74 2291 11 term term NN cord-015021-pol2qm74 2291 12 hypoxia hypoxia NN cord-015021-pol2qm74 2291 13 experiments experiment NNS cord-015021-pol2qm74 2291 14 in in IN cord-015021-pol2qm74 2291 15 awake awake JJ cord-015021-pol2qm74 2291 16 animals animal NNS cord-015021-pol2qm74 2291 17 , , , cord-015021-pol2qm74 2291 18 we -PRON- PRP cord-015021-pol2qm74 2291 19 preferred prefer VBD cord-015021-pol2qm74 2291 20 to to TO cord-015021-pol2qm74 2291 21 implement implement VB cord-015021-pol2qm74 2291 22 the the DT cord-015021-pol2qm74 2291 23 studies study NNS cord-015021-pol2qm74 2291 24 under under IN cord-015021-pol2qm74 2291 25 anesthesia anesthesia NN cord-015021-pol2qm74 2291 26 for for IN cord-015021-pol2qm74 2291 27 ethical ethical JJ cord-015021-pol2qm74 2291 28 reasons reason NNS cord-015021-pol2qm74 2291 29 , , , cord-015021-pol2qm74 2291 30 although although IN cord-015021-pol2qm74 2291 31 regulatory regulatory JJ cord-015021-pol2qm74 2291 32 functions function NNS cord-015021-pol2qm74 2291 33 for for IN cord-015021-pol2qm74 2291 34 ventilation ventilation NN cord-015021-pol2qm74 2291 35 might may MD cord-015021-pol2qm74 2291 36 be be VB cord-015021-pol2qm74 2291 37 influenced influence VBN cord-015021-pol2qm74 2291 38 . . . cord-015021-pol2qm74 2292 1 Animal animal NN cord-015021-pol2qm74 2292 2 studies study NNS cord-015021-pol2qm74 2292 3 demonstrated demonstrate VBD cord-015021-pol2qm74 2292 4 that that IN cord-015021-pol2qm74 2292 5 the the DT cord-015021-pol2qm74 2292 6 intravenous intravenous JJ cord-015021-pol2qm74 2292 7 injection injection NN cord-015021-pol2qm74 2292 8 of of IN cord-015021-pol2qm74 2292 9 the the DT cord-015021-pol2qm74 2292 10 polypeptide polypeptide NN cord-015021-pol2qm74 2292 11 initiates initiate VBZ cord-015021-pol2qm74 2292 12 fibrin fibrin NN cord-015021-pol2qm74 2292 13 formation formation NN cord-015021-pol2qm74 2292 14 in in IN cord-015021-pol2qm74 2292 15 the the DT cord-015021-pol2qm74 2292 16 peritubular peritubular JJ cord-015021-pol2qm74 2292 17 vessels vessel NNS cord-015021-pol2qm74 2292 18 . . . cord-015021-pol2qm74 2293 1 Keeping keep VBG cord-015021-pol2qm74 2293 2 the the DT cord-015021-pol2qm74 2293 3 animals animal NNS cord-015021-pol2qm74 2293 4 under under IN cord-015021-pol2qm74 2293 5 hypoxic hypoxic JJ cord-015021-pol2qm74 2293 6 conditions condition NNS cord-015021-pol2qm74 2293 7 induces induce VBZ cord-015021-pol2qm74 2293 8 similar similar JJ cord-015021-pol2qm74 2293 9 effects effect NNS cord-015021-pol2qm74 2293 10 , , , cord-015021-pol2qm74 2293 11 which which WDT cord-015021-pol2qm74 2293 12 are be VBP cord-015021-pol2qm74 2293 13 reduced reduce VBN cord-015021-pol2qm74 2293 14 by by IN cord-015021-pol2qm74 2293 15 a a DT cord-015021-pol2qm74 2293 16 rabbit rabbit NN cord-015021-pol2qm74 2293 17 - - HYPH cord-015021-pol2qm74 2293 18 antiserum antiserum NN cord-015021-pol2qm74 2293 19 against against IN cord-015021-pol2qm74 2293 20 the the DT cord-015021-pol2qm74 2293 21 new new JJ cord-015021-pol2qm74 2293 22 protein protein NN cord-015021-pol2qm74 2293 23 . . . cord-015021-pol2qm74 2294 1 In in IN cord-015021-pol2qm74 2294 2 conclusion conclusion NN cord-015021-pol2qm74 2294 3 , , , cord-015021-pol2qm74 2294 4 the the DT cord-015021-pol2qm74 2294 5 new new JJ cord-015021-pol2qm74 2294 6 polypeptide polypeptide NN cord-015021-pol2qm74 2294 7 obviously obviously RB cord-015021-pol2qm74 2294 8 contributes contribute VBZ cord-015021-pol2qm74 2294 9 to to IN cord-015021-pol2qm74 2294 10 the the DT cord-015021-pol2qm74 2294 11 pathogenesis pathogenesis NN cord-015021-pol2qm74 2294 12 of of IN cord-015021-pol2qm74 2294 13 acute acute JJ cord-015021-pol2qm74 2294 14 renal renal JJ cord-015021-pol2qm74 2294 15 failure failure NN cord-015021-pol2qm74 2294 16 by by IN cord-015021-pol2qm74 2294 17 tubular tubular JJ cord-015021-pol2qm74 2294 18 necrosis necrosis NN cord-015021-pol2qm74 2294 19 during during IN cord-015021-pol2qm74 2294 20 and and CC cord-015021-pol2qm74 2294 21 after after IN cord-015021-pol2qm74 2294 22 hypoxic hypoxic JJ cord-015021-pol2qm74 2294 23 events event NNS cord-015021-pol2qm74 2294 24 . . . cord-015021-pol2qm74 2295 1 The the DT cord-015021-pol2qm74 2295 2 use use NN cord-015021-pol2qm74 2295 3 of of IN cord-015021-pol2qm74 2295 4 verapamil verapamil NN cord-015021-pol2qm74 2295 5 as as IN cord-015021-pol2qm74 2295 6 cardioprotective cardioprotective JJ cord-015021-pol2qm74 2295 7 agents agent NNS cord-015021-pol2qm74 2295 8 for for IN cord-015021-pol2qm74 2295 9 management management NN cord-015021-pol2qm74 2295 10 of of IN cord-015021-pol2qm74 2295 11 patients patient NNS cord-015021-pol2qm74 2295 12 with with IN cord-015021-pol2qm74 2295 13 acute acute JJ cord-015021-pol2qm74 2295 14 ischemic ischemic JJ cord-015021-pol2qm74 2295 15 / / SYM cord-015021-pol2qm74 2295 16 reperfused reperfused JJ cord-015021-pol2qm74 2295 17 heart heart NN cord-015021-pol2qm74 2295 18 is be VBZ cord-015021-pol2qm74 2295 19 based base VBN cord-015021-pol2qm74 2295 20 on on IN cord-015021-pol2qm74 2295 21 the the DT cord-015021-pol2qm74 2295 22 assumption assumption NN cord-015021-pol2qm74 2295 23 that that IN cord-015021-pol2qm74 2295 24 the the DT cord-015021-pol2qm74 2295 25 increased increase VBN cord-015021-pol2qm74 2295 26 intracellular intracellular JJ cord-015021-pol2qm74 2295 27 Ca+ Ca+ NNP cord-015021-pol2qm74 2295 28 level level NN cord-015021-pol2qm74 2295 29 is be VBZ cord-015021-pol2qm74 2295 30 a a DT cord-015021-pol2qm74 2295 31 key key JJ cord-015021-pol2qm74 2295 32 factor factor NN cord-015021-pol2qm74 2295 33 in in IN cord-015021-pol2qm74 2295 34 causing cause VBG cord-015021-pol2qm74 2295 35 cell cell NN cord-015021-pol2qm74 2295 36 death death NN cord-015021-pol2qm74 2295 37 . . . cord-015021-pol2qm74 2296 1 Our -PRON- PRP$ cord-015021-pol2qm74 2296 2 in in FW cord-015021-pol2qm74 2296 3 vitro vitro FW cord-015021-pol2qm74 2296 4 study study NN cord-015021-pol2qm74 2296 5 was be VBD cord-015021-pol2qm74 2296 6 designed design VBN cord-015021-pol2qm74 2296 7 to to TO cord-015021-pol2qm74 2296 8 focus focus VB cord-015021-pol2qm74 2296 9 on on IN cord-015021-pol2qm74 2296 10 effects effect NNS cord-015021-pol2qm74 2296 11 of of IN cord-015021-pol2qm74 2296 12 verapamil verapamil NN cord-015021-pol2qm74 2296 13 on on IN cord-015021-pol2qm74 2296 14 the the DT cord-015021-pol2qm74 2296 15 metabolic metabolic JJ cord-015021-pol2qm74 2296 16 potential potential NN cord-015021-pol2qm74 2296 17 of of IN cord-015021-pol2qm74 2296 18 cardiac cardiac JJ cord-015021-pol2qm74 2296 19 slices slice NNS cord-015021-pol2qm74 2296 20 after after IN cord-015021-pol2qm74 2296 21 reversible reversible JJ cord-015021-pol2qm74 2296 22 ischemia ischemia NN cord-015021-pol2qm74 2296 23 in in IN cord-015021-pol2qm74 2296 24 rats rat NNS cord-015021-pol2qm74 2296 25 . . . cord-015021-pol2qm74 2297 1 The the DT cord-015021-pol2qm74 2297 2 material material NN cord-015021-pol2qm74 2297 3 consisted consist VBD cord-015021-pol2qm74 2297 4 of of IN cord-015021-pol2qm74 2297 5 two two CD cord-015021-pol2qm74 2297 6 main main JJ cord-015021-pol2qm74 2297 7 groups group NNS cord-015021-pol2qm74 2297 8 : : : cord-015021-pol2qm74 2297 9 group group NN cord-015021-pol2qm74 2297 10 A A NNP cord-015021-pol2qm74 2297 11 ( ( -LRB- cord-015021-pol2qm74 2297 12 non non FW cord-015021-pol2qm74 2297 13 ischemia ischemia NN cord-015021-pol2qm74 2297 14 / / SYM cord-015021-pol2qm74 2297 15 reperfusion reperfusion NN cord-015021-pol2qm74 2297 16 group group NN cord-015021-pol2qm74 2297 17 ) ) -RRB- cord-015021-pol2qm74 2297 18 and and CC cord-015021-pol2qm74 2297 19 group group NN cord-015021-pol2qm74 2297 20 B B NNP cord-015021-pol2qm74 2297 21 ( ( -LRB- cord-015021-pol2qm74 2297 22 ischemia ischemia NN cord-015021-pol2qm74 2297 23 / / SYM cord-015021-pol2qm74 2297 24 reperfusion reperfusion NN cord-015021-pol2qm74 2297 25 group group NN cord-015021-pol2qm74 2297 26 ) ) -RRB- cord-015021-pol2qm74 2297 27 , , , cord-015021-pol2qm74 2297 28 Each each DT cord-015021-pol2qm74 2297 29 is be VBZ cord-015021-pol2qm74 2297 30 subdivided subdivide VBN cord-015021-pol2qm74 2297 31 into into IN cord-015021-pol2qm74 2297 32 two two CD cord-015021-pol2qm74 2297 33 subgroups subgroup NNS cord-015021-pol2qm74 2297 34 ( ( -LRB- cord-015021-pol2qm74 2297 35 a a NN cord-015021-pol2qm74 2297 36 and and CC cord-015021-pol2qm74 2297 37 b b LS cord-015021-pol2qm74 2297 38 ) ) -RRB- cord-015021-pol2qm74 2297 39 . . . cord-015021-pol2qm74 2298 1 Each each DT cord-015021-pol2qm74 2298 2 subgroup subgroup NN cord-015021-pol2qm74 2298 3 included include VBD cord-015021-pol2qm74 2298 4 10 10 CD cord-015021-pol2qm74 2298 5 rat rat NN cord-015021-pol2qm74 2298 6 hearts heart NNS cord-015021-pol2qm74 2298 7 . . . cord-015021-pol2qm74 2299 1 Group Group NNP cord-015021-pol2qm74 2299 2 Aa Aa NNP cord-015021-pol2qm74 2299 3 is be VBZ cord-015021-pol2qm74 2299 4 the the DT cord-015021-pol2qm74 2299 5 control control NN cord-015021-pol2qm74 2299 6 group group NN cord-015021-pol2qm74 2299 7 , , , cord-015021-pol2qm74 2299 8 Group Group NNP cord-015021-pol2qm74 2299 9 Ab Ab NNP cord-015021-pol2qm74 2300 1 is be VBZ cord-015021-pol2qm74 2300 2 verapami verapami NNP cord-015021-pol2qm74 2300 3 ] ] -RRB- cord-015021-pol2qm74 2300 4 added add VBN cord-015021-pol2qm74 2300 5 group group NN cord-015021-pol2qm74 2300 6 . . . cord-015021-pol2qm74 2301 1 Group Group NNP cord-015021-pol2qm74 2301 2 Ba Ba NNP cord-015021-pol2qm74 2301 3 is be VBZ cord-015021-pol2qm74 2301 4 ischemia ischemia NN cord-015021-pol2qm74 2301 5 group group NN cord-015021-pol2qm74 2301 6 without without IN cord-015021-pol2qm74 2301 7 verapamil verapamil NN cord-015021-pol2qm74 2301 8 . . . cord-015021-pol2qm74 2302 1 Group Group NNP cord-015021-pol2qm74 2302 2 Bb Bb NNP cord-015021-pol2qm74 2302 3 is be VBZ cord-015021-pol2qm74 2302 4 verapamil verapamil NN cord-015021-pol2qm74 2302 5 added add VBN cord-015021-pol2qm74 2302 6 group group NN cord-015021-pol2qm74 2302 7 . . . cord-015021-pol2qm74 2303 1 Ischemic ischemic JJ cord-015021-pol2qm74 2303 2 cardiac cardiac JJ cord-015021-pol2qm74 2303 3 slices slice NNS cord-015021-pol2qm74 2303 4 were be VBD cord-015021-pol2qm74 2303 5 obtained obtain VBN cord-015021-pol2qm74 2303 6 from from IN cord-015021-pol2qm74 2303 7 rats rat NNS cord-015021-pol2qm74 2303 8 subjected subject VBN cord-015021-pol2qm74 2303 9 to to IN cord-015021-pol2qm74 2303 10 15 15 CD cord-015021-pol2qm74 2303 11 min min NN cord-015021-pol2qm74 2303 12 . . . cord-015021-pol2qm74 2304 1 haemorrhage haemorrhage NN cord-015021-pol2qm74 2304 2 to to TO cord-015021-pol2qm74 2304 3 induce induce VB cord-015021-pol2qm74 2304 4 reversible reversible JJ cord-015021-pol2qm74 2304 5 global global JJ cord-015021-pol2qm74 2304 6 ischemia ischemia NN cord-015021-pol2qm74 2304 7 . . . cord-015021-pol2qm74 2305 1 Both both DT cord-015021-pol2qm74 2305 2 nonischemic nonischemic JJ cord-015021-pol2qm74 2305 3 and and CC cord-015021-pol2qm74 2305 4 ischemic ischemic JJ cord-015021-pol2qm74 2305 5 cardiac cardiac JJ cord-015021-pol2qm74 2305 6 slices slice NNS cord-015021-pol2qm74 2305 7 were be VBD cord-015021-pol2qm74 2305 8 placed place VBN cord-015021-pol2qm74 2305 9 in in IN cord-015021-pol2qm74 2305 10 well well RB cord-015021-pol2qm74 2305 11 oxygenated oxygenated JJ cord-015021-pol2qm74 2305 12 krebs krebs NNP cord-015021-pol2qm74 2305 13 Ringer Ringer NNP cord-015021-pol2qm74 2305 14 phosphate phosphate NN cord-015021-pol2qm74 2305 15 buffer buffer NN cord-015021-pol2qm74 2305 16 containing contain VBG cord-015021-pol2qm74 2305 17 150 150 CD cord-015021-pol2qm74 2305 18 mg% mg% CD cord-015021-pol2qm74 2305 19 glucose glucose NN cord-015021-pol2qm74 2305 20 & & CC cord-015021-pol2qm74 2305 21 5 5 CD cord-015021-pol2qm74 2305 22 gm% gm% CD cord-015021-pol2qm74 2305 23 bovine bovine JJ cord-015021-pol2qm74 2305 24 albumin albumin NN cord-015021-pol2qm74 2305 25 and and CC cord-015021-pol2qm74 2305 26 incubated incubate VBN cord-015021-pol2qm74 2305 27 in in IN cord-015021-pol2qm74 2305 28 Dubnoff Dubnoff NNP cord-015021-pol2qm74 2305 29 shaking shake VBG cord-015021-pol2qm74 2305 30 water water NN cord-015021-pol2qm74 2305 31 bath bath NN cord-015021-pol2qm74 2305 32 for for IN cord-015021-pol2qm74 2305 33 60min 60min NN cord-015021-pol2qm74 2305 34 at at IN cord-015021-pol2qm74 2305 35 37 37 CD cord-015021-pol2qm74 2305 36 ° ° NN cord-015021-pol2qm74 2305 37 C c NN cord-015021-pol2qm74 2306 1 The the DT cord-015021-pol2qm74 2306 2 results result NNS cord-015021-pol2qm74 2306 3 revealed reveal VBD cord-015021-pol2qm74 2306 4 that that IN cord-015021-pol2qm74 2306 5 there there EX cord-015021-pol2qm74 2306 6 was be VBD cord-015021-pol2qm74 2306 7 an an DT cord-015021-pol2qm74 2306 8 enhancement enhancement NN cord-015021-pol2qm74 2306 9 in in IN cord-015021-pol2qm74 2306 10 release release NN cord-015021-pol2qm74 2306 11 of of IN cord-015021-pol2qm74 2306 12 free free JJ cord-015021-pol2qm74 2306 13 fatty fatty JJ cord-015021-pol2qm74 2306 14 acids acid NNS cord-015021-pol2qm74 2306 15 ( ( -LRB- cord-015021-pol2qm74 2306 16 FFA FFA NNP cord-015021-pol2qm74 2306 17 ) ) -RRB- cord-015021-pol2qm74 2306 18 ( ( -LRB- cord-015021-pol2qm74 2306 19 240 240 CD cord-015021-pol2qm74 2306 20 % % NN cord-015021-pol2qm74 2306 21 ) ) -RRB- cord-015021-pol2qm74 2306 22 and and CC cord-015021-pol2qm74 2306 23 lactate lactate NN cord-015021-pol2qm74 2306 24 ( ( -LRB- cord-015021-pol2qm74 2306 25 163 163 CD cord-015021-pol2qm74 2306 26 % % NN cord-015021-pol2qm74 2306 27 ) ) -RRB- cord-015021-pol2qm74 2306 28 and and CC cord-015021-pol2qm74 2306 29 in in IN cord-015021-pol2qm74 2306 30 glucose glucose NN cord-015021-pol2qm74 2306 31 uptake uptake NN cord-015021-pol2qm74 2306 32 ( ( -LRB- cord-015021-pol2qm74 2306 33 160 160 CD cord-015021-pol2qm74 2306 34 % % NN cord-015021-pol2qm74 2306 35 ) ) -RRB- cord-015021-pol2qm74 2306 36 in in IN cord-015021-pol2qm74 2306 37 group group NN cord-015021-pol2qm74 2306 38 Ba Ba NNP cord-015021-pol2qm74 2306 39 as as IN cord-015021-pol2qm74 2306 40 compared compare VBN cord-015021-pol2qm74 2306 41 with with IN cord-015021-pol2qm74 2306 42 group group NN cord-015021-pol2qm74 2306 43 Aa Aa NNP cord-015021-pol2qm74 2306 44 . . . cord-015021-pol2qm74 2307 1 These these DT cord-015021-pol2qm74 2307 2 metabolic metabolic JJ cord-015021-pol2qm74 2307 3 alternations alternation NNS cord-015021-pol2qm74 2307 4 produced produce VBN cord-015021-pol2qm74 2307 5 by by IN cord-015021-pol2qm74 2307 6 ischemic ischemic JJ cord-015021-pol2qm74 2307 7 cardiac cardiac JJ cord-015021-pol2qm74 2307 8 slices slice NNS cord-015021-pol2qm74 2307 9 were be VBD cord-015021-pol2qm74 2307 10 reversed reverse VBN cord-015021-pol2qm74 2307 11 by by IN cord-015021-pol2qm74 2307 12 verapamil verapamil NN cord-015021-pol2qm74 2307 13 addition addition NN cord-015021-pol2qm74 2307 14 ( ( -LRB- cord-015021-pol2qm74 2307 15 200 200 CD cord-015021-pol2qm74 2307 16 ml% ml% NN cord-015021-pol2qm74 2307 17 ) ) -RRB- cord-015021-pol2qm74 2307 18 but but CC cord-015021-pol2qm74 2307 19 in in IN cord-015021-pol2qm74 2307 20 group group NN cord-015021-pol2qm74 2307 21 Ab Ab NNP cord-015021-pol2qm74 2307 22 verpamil verpamil NNP cord-015021-pol2qm74 2307 23 did do VBD cord-015021-pol2qm74 2307 24 not not RB cord-015021-pol2qm74 2307 25 alter alter VB cord-015021-pol2qm74 2307 26 the the DT cord-015021-pol2qm74 2307 27 release release NN cord-015021-pol2qm74 2307 28 of of IN cord-015021-pol2qm74 2307 29 FFA FFA NNP cord-015021-pol2qm74 2307 30 & & CC cord-015021-pol2qm74 2307 31 lactate lactate NN cord-015021-pol2qm74 2307 32 from from IN cord-015021-pol2qm74 2307 33 non non JJ cord-015021-pol2qm74 2307 34 - - JJ cord-015021-pol2qm74 2307 35 ischemic ischemic JJ cord-015021-pol2qm74 2307 36 cardiac cardiac JJ cord-015021-pol2qm74 2307 37 slices slice NNS cord-015021-pol2qm74 2307 38 , , , cord-015021-pol2qm74 2307 39 whereas whereas IN cord-015021-pol2qm74 2307 40 it -PRON- PRP cord-015021-pol2qm74 2307 41 inhibited inhibit VBD cord-015021-pol2qm74 2307 42 glucose glucose NN cord-015021-pol2qm74 2307 43 uptake uptake NN cord-015021-pol2qm74 2307 44 from from IN cord-015021-pol2qm74 2307 45 these these DT cord-015021-pol2qm74 2307 46 slices slice NNS cord-015021-pol2qm74 2307 47 by by IN cord-015021-pol2qm74 2307 48 67 67 CD cord-015021-pol2qm74 2307 49 % % NN cord-015021-pol2qm74 2307 50 . . . cord-015021-pol2qm74 2308 1 The the DT cord-015021-pol2qm74 2308 2 improvement improvement NN cord-015021-pol2qm74 2308 3 of of IN cord-015021-pol2qm74 2308 4 the the DT cord-015021-pol2qm74 2308 5 metabolic metabolic JJ cord-015021-pol2qm74 2308 6 intervention intervention NN cord-015021-pol2qm74 2308 7 of of IN cord-015021-pol2qm74 2308 8 ischemic ischemic JJ cord-015021-pol2qm74 2308 9 myocardium myocardium NN cord-015021-pol2qm74 2308 10 indicates indicate VBZ cord-015021-pol2qm74 2308 11 that that IN cord-015021-pol2qm74 2308 12 verapamil verapamil NN cord-015021-pol2qm74 2308 13 may may MD cord-015021-pol2qm74 2308 14 be be VB cord-015021-pol2qm74 2308 15 of of IN cord-015021-pol2qm74 2308 16 importance importance NN cord-015021-pol2qm74 2308 17 in in IN cord-015021-pol2qm74 2308 18 reducing reduce VBG cord-015021-pol2qm74 2308 19 the the DT cord-015021-pol2qm74 2308 20 extent extent NN cord-015021-pol2qm74 2308 21 and and CC cord-015021-pol2qm74 2308 22 severity severity NN cord-015021-pol2qm74 2308 23 of of IN cord-015021-pol2qm74 2308 24 acute acute JJ cord-015021-pol2qm74 2308 25 myocardial myocardial JJ cord-015021-pol2qm74 2308 26 ischemic ischemic JJ cord-015021-pol2qm74 2308 27 injury injury NN cord-015021-pol2qm74 2308 28 in in IN cord-015021-pol2qm74 2308 29 acute acute JJ cord-015021-pol2qm74 2308 30 haemorrhage haemorrhage NN cord-015021-pol2qm74 2308 31 . . . cord-015021-pol2qm74 2309 1 Severe severe JJ cord-015021-pol2qm74 2309 2 endothelial endothelial JJ cord-015021-pol2qm74 2309 3 dysfunction dysfunction NN cord-015021-pol2qm74 2309 4 occurs occur VBZ cord-015021-pol2qm74 2309 5 following follow VBG cord-015021-pol2qm74 2309 6 injury injury NN cord-015021-pol2qm74 2309 7 to to IN cord-015021-pol2qm74 2309 8 carotid carotid JJ cord-015021-pol2qm74 2309 9 arteries artery NNS cord-015021-pol2qm74 2309 10 which which WDT cord-015021-pol2qm74 2309 11 is be VBZ cord-015021-pol2qm74 2309 12 characterized characterize VBN cord-015021-pol2qm74 2309 13 by by IN cord-015021-pol2qm74 2309 14 a a DT cord-015021-pol2qm74 2309 15 decreased decrease VBN cord-015021-pol2qm74 2309 16 ability ability NN cord-015021-pol2qm74 2309 17 of of IN cord-015021-pol2qm74 2309 18 these these DT cord-015021-pol2qm74 2309 19 arteries artery NNS cord-015021-pol2qm74 2309 20 to to TO cord-015021-pol2qm74 2309 21 dilate dilate VB cord-015021-pol2qm74 2309 22 when when WRB cord-015021-pol2qm74 2309 23 challenged challenge VBN cord-015021-pol2qm74 2309 24 with with IN cord-015021-pol2qm74 2309 25 ACh ACh NNP cord-015021-pol2qm74 2309 26 or or CC cord-015021-pol2qm74 2309 27 A23187 A23187 NNP cord-015021-pol2qm74 2309 28 , , , cord-015021-pol2qm74 2309 29 but but CC cord-015021-pol2qm74 2309 30 not not RB cord-015021-pol2qm74 2309 31 with with IN cord-015021-pol2qm74 2309 32 a a DT cord-015021-pol2qm74 2309 33 direct direct JJ cord-015021-pol2qm74 2309 34 vasodilator vasodilator NN cord-015021-pol2qm74 2309 35 ( ( -LRB- cord-015021-pol2qm74 2309 36 NaNO2 NaNO2 NNP cord-015021-pol2qm74 2309 37 ) ) -RRB- cord-015021-pol2qm74 2309 38 . . . cord-015021-pol2qm74 2310 1 This this DT cord-015021-pol2qm74 2310 2 failure failure NN cord-015021-pol2qm74 2310 3 to to TO cord-015021-pol2qm74 2310 4 relax relax VB cord-015021-pol2qm74 2310 5 to to IN cord-015021-pol2qm74 2310 6 ACh ACh NNP cord-015021-pol2qm74 2310 7 and and CC cord-015021-pol2qm74 2310 8 A23187 A23187 NNP cord-015021-pol2qm74 2310 9 reflects reflect VBZ cord-015021-pol2qm74 2310 10 an an DT cord-015021-pol2qm74 2310 11 inability inability NN cord-015021-pol2qm74 2310 12 of of IN cord-015021-pol2qm74 2310 13 endothelium endothelium NN cord-015021-pol2qm74 2310 14 to to TO cord-015021-pol2qm74 2310 15 generate generate VB cord-015021-pol2qm74 2310 16 EDRF EDRF NNP cord-015021-pol2qm74 2310 17 , , , cord-015021-pol2qm74 2310 18 but but CC cord-015021-pol2qm74 2310 19 relaxation relaxation NN cord-015021-pol2qm74 2310 20 recovers recover VBZ cord-015021-pol2qm74 2310 21 gradually gradually RB cord-015021-pol2qm74 2310 22 to to TO cord-015021-pol2qm74 2310 23 control control VB cord-015021-pol2qm74 2310 24 values value NNS cord-015021-pol2qm74 2310 25 by by IN cord-015021-pol2qm74 2310 26 2 2 CD cord-015021-pol2qm74 2310 27 weeks week NNS cord-015021-pol2qm74 2310 28 . . . cord-015021-pol2qm74 2311 1 Exogenous exogenous JJ cord-015021-pol2qm74 2311 2 NO no DT cord-015021-pol2qm74 2311 3 donors donor NNS cord-015021-pol2qm74 2311 4 ( ( -LRB- cord-015021-pol2qm74 2311 5 e.g. e.g. RB cord-015021-pol2qm74 2311 6 , , , cord-015021-pol2qm74 2311 7 C87 C87 NNP cord-015021-pol2qm74 2311 8 - - HYPH cord-015021-pol2qm74 2311 9 3754 3754 CD cord-015021-pol2qm74 2311 10 or or CC cord-015021-pol2qm74 2311 11 SPM-5185 SPM-5185 NNP cord-015021-pol2qm74 2311 12 ) ) -RRB- cord-015021-pol2qm74 2311 13 , , , cord-015021-pol2qm74 2311 14 accelerate accelerate VB cord-015021-pol2qm74 2311 15 the the DT cord-015021-pol2qm74 2311 16 recovery recovery NN cord-015021-pol2qm74 2311 17 of of IN cord-015021-pol2qm74 2311 18 the the DT cord-015021-pol2qm74 2311 19 injured injured JJ cord-015021-pol2qm74 2311 20 endothelium endothelium NN cord-015021-pol2qm74 2311 21 in in IN cord-015021-pol2qm74 2311 22 rat rat NN cord-015021-pol2qm74 2311 23 carotid carotid JJ cord-015021-pol2qm74 2311 24 arteries artery NNS cord-015021-pol2qm74 2311 25 . . . cord-015021-pol2qm74 2312 1 Intravenous intravenous JJ cord-015021-pol2qm74 2312 2 infusion infusion NN cord-015021-pol2qm74 2312 3 of of IN cord-015021-pol2qm74 2312 4 an an DT cord-015021-pol2qm74 2312 5 NO no JJ cord-015021-pol2qm74 2312 6 donor donor NN cord-015021-pol2qm74 2312 7 ( ( -LRB- cord-015021-pol2qm74 2312 8 30 30 CD cord-015021-pol2qm74 2312 9 p.g p.g NNP cord-015021-pol2qm74 2312 10 / / SYM cord-015021-pol2qm74 2312 11 day day NN cord-015021-pol2qm74 2312 12 ) ) -RRB- cord-015021-pol2qm74 2312 13 with with IN cord-015021-pol2qm74 2312 14 an an DT cord-015021-pol2qm74 2312 15 implanted implant VBN cord-015021-pol2qm74 2312 16 osmotic osmotic JJ cord-015021-pol2qm74 2312 17 pump pump NN cord-015021-pol2qm74 2312 18 significantly significantly RB cord-015021-pol2qm74 2312 19 accelerated accelerate VBD cord-015021-pol2qm74 2312 20 the the DT cord-015021-pol2qm74 2312 21 recovery recovery NN cord-015021-pol2qm74 2312 22 of of IN cord-015021-pol2qm74 2312 23 regenerated regenerated JJ cord-015021-pol2qm74 2312 24 endothelium endothelium NN cord-015021-pol2qm74 2312 25 to to TO cord-015021-pol2qm74 2312 26 produce produce VB cord-015021-pol2qm74 2312 27 EDRF EDRF NNP cord-015021-pol2qm74 2312 28 at at IN cord-015021-pol2qm74 2312 29 7 7 CD cord-015021-pol2qm74 2312 30 days day NNS cord-015021-pol2qm74 2312 31 . . . cord-015021-pol2qm74 2313 1 Rat rat NN cord-015021-pol2qm74 2313 2 carotid carotid JJ cord-015021-pol2qm74 2313 3 artery artery NN cord-015021-pol2qm74 2313 4 rings ring NNS cord-015021-pol2qm74 2313 5 relaxed relax VBN cord-015021-pol2qm74 2313 6 only only RB cord-015021-pol2qm74 2313 7 17 17 CD cord-015021-pol2qm74 2313 8 + + SYM cord-015021-pol2qm74 2313 9 5 5 CD cord-015021-pol2qm74 2313 10 % % NN cord-015021-pol2qm74 2313 11 and and CC cord-015021-pol2qm74 2313 12 15 15 CD cord-015021-pol2qm74 2313 13 + + CD cord-015021-pol2qm74 2314 1 5 5 CD cord-015021-pol2qm74 2314 2 % % NN cord-015021-pol2qm74 2314 3 to to TO cord-015021-pol2qm74 2314 4 10 10 CD cord-015021-pol2qm74 2314 5 gM gm NN cord-015021-pol2qm74 2314 6 ACh ACh NNP cord-015021-pol2qm74 2314 7 in in IN cord-015021-pol2qm74 2314 8 vehicle vehicle NN cord-015021-pol2qm74 2314 9 treated treat VBD cord-015021-pol2qm74 2314 10 rats rat NNS cord-015021-pol2qm74 2314 11 and and CC cord-015021-pol2qm74 2314 12 in in IN cord-015021-pol2qm74 2314 13 inactive inactive JJ cord-015021-pol2qm74 2314 14 NO no DT cord-015021-pol2qm74 2314 15 donor donor NN cord-015021-pol2qm74 2314 16 treated treat VBN cord-015021-pol2qm74 2314 17 rats rat NNS cord-015021-pol2qm74 2314 18 respectively respectively RB cord-015021-pol2qm74 2314 19 7 7 CD cord-015021-pol2qm74 2314 20 days day NNS cord-015021-pol2qm74 2314 21 following follow VBG cord-015021-pol2qm74 2314 22 injury injury NN cord-015021-pol2qm74 2314 23 compared compare VBN cord-015021-pol2qm74 2314 24 with with IN cord-015021-pol2qm74 2314 25 67 67 CD cord-015021-pol2qm74 2314 26 + + SYM cord-015021-pol2qm74 2314 27 6 6 CD cord-015021-pol2qm74 2314 28 % % NN cord-015021-pol2qm74 2314 29 in in IN cord-015021-pol2qm74 2314 30 NO no DT cord-015021-pol2qm74 2314 31 donor donor NN cord-015021-pol2qm74 2314 32 rats rat NNS cord-015021-pol2qm74 2314 33 ( ( -LRB- cord-015021-pol2qm74 2314 34 p<0.001 p<0.001 CD cord-015021-pol2qm74 2314 35 ) ) -RRB- cord-015021-pol2qm74 2314 36 . . . cord-015021-pol2qm74 2315 1 Relaxation relaxation NN cord-015021-pol2qm74 2315 2 to to IN cord-015021-pol2qm74 2315 3 100 100 CD cord-015021-pol2qm74 2316 1 gM gM NNP cord-015021-pol2qm74 2317 1 NAN02 NAN02 NNP cord-015021-pol2qm74 2317 2 was be VBD cord-015021-pol2qm74 2317 3 normal normal JJ cord-015021-pol2qm74 2317 4 in in IN cord-015021-pol2qm74 2317 5 all all DT cord-015021-pol2qm74 2317 6 groups group NNS cord-015021-pol2qm74 2317 7 indicating indicate VBG cord-015021-pol2qm74 2317 8 that that IN cord-015021-pol2qm74 2317 9 the the DT cord-015021-pol2qm74 2317 10 differences difference NNS cord-015021-pol2qm74 2317 11 in in IN cord-015021-pol2qm74 2317 12 relaxation relaxation NN cord-015021-pol2qm74 2317 13 were be VBD cord-015021-pol2qm74 2317 14 not not RB cord-015021-pol2qm74 2317 15 the the DT cord-015021-pol2qm74 2317 16 result result NN cord-015021-pol2qm74 2317 17 of of IN cord-015021-pol2qm74 2317 18 damage damage NN cord-015021-pol2qm74 2317 19 to to IN cord-015021-pol2qm74 2317 20 vascular vascular JJ cord-015021-pol2qm74 2317 21 smooth smooth JJ cord-015021-pol2qm74 2317 22 muscle muscle NN cord-015021-pol2qm74 2317 23 . . . cord-015021-pol2qm74 2318 1 Contraction contraction NN cord-015021-pol2qm74 2318 2 to to IN cord-015021-pol2qm74 2318 3 L l NN cord-015021-pol2qm74 2318 4 - - HYPH cord-015021-pol2qm74 2318 5 NAME NAME NNP cord-015021-pol2qm74 2318 6 ( ( -LRB- cord-015021-pol2qm74 2318 7 1 1 CD cord-015021-pol2qm74 2318 8 mM mm CD cord-015021-pol2qm74 2318 9 ) ) -RRB- cord-015021-pol2qm74 2318 10 was be VBD cord-015021-pol2qm74 2318 11 markedly markedly RB cord-015021-pol2qm74 2318 12 reduced reduce VBN cord-015021-pol2qm74 2318 13 by by IN cord-015021-pol2qm74 2318 14 injury injury NN cord-015021-pol2qm74 2318 15 , , , cord-015021-pol2qm74 2318 16 but but CC cord-015021-pol2qm74 2318 17 was be VBD cord-015021-pol2qm74 2318 18 protected protect VBN cord-015021-pol2qm74 2318 19 by by IN cord-015021-pol2qm74 2318 20 NO no DT cord-015021-pol2qm74 2318 21 donors donor NNS cord-015021-pol2qm74 2318 22 ( ( -LRB- cord-015021-pol2qm74 2318 23 p<0.01 p<0.01 NNP cord-015021-pol2qm74 2318 24 ) ) -RRB- cord-015021-pol2qm74 2318 25 . . . cord-015021-pol2qm74 2319 1 Thus thus RB cord-015021-pol2qm74 2319 2 , , , cord-015021-pol2qm74 2319 3 exogenous exogenous JJ cord-015021-pol2qm74 2319 4 NO no DT cord-015021-pol2qm74 2319 5 donors donor NNS cord-015021-pol2qm74 2319 6 enhance enhance VBP cord-015021-pol2qm74 2319 7 the the DT cord-015021-pol2qm74 2319 8 ability ability NN cord-015021-pol2qm74 2319 9 of of IN cord-015021-pol2qm74 2319 10 the the DT cord-015021-pol2qm74 2319 11 endothelium endothelium NN cord-015021-pol2qm74 2319 12 to to TO cord-015021-pol2qm74 2319 13 regenerate regenerate VB cord-015021-pol2qm74 2319 14 and and CC cord-015021-pol2qm74 2319 15 to to TO cord-015021-pol2qm74 2319 16 release release VB cord-015021-pol2qm74 2319 17 EDRF EDRF NNP cord-015021-pol2qm74 2319 18 in in IN cord-015021-pol2qm74 2319 19 response response NN cord-015021-pol2qm74 2319 20 to to IN cord-015021-pol2qm74 2319 21 endothelium endothelium NN cord-015021-pol2qm74 2319 22 - - HYPH cord-015021-pol2qm74 2319 23 dependent dependent JJ cord-015021-pol2qm74 2319 24 vasodilators vasodilator NNS cord-015021-pol2qm74 2319 25 . . . cord-015021-pol2qm74 2320 1 This this DT cord-015021-pol2qm74 2320 2 may may MD cord-015021-pol2qm74 2320 3 be be VB cord-015021-pol2qm74 2320 4 due due JJ cord-015021-pol2qm74 2320 5 to to IN cord-015021-pol2qm74 2320 6 an an DT cord-015021-pol2qm74 2320 7 anti anti JJ cord-015021-pol2qm74 2320 8 - - JJ cord-015021-pol2qm74 2320 9 proliferative proliferative JJ cord-015021-pol2qm74 2320 10 and and CC cord-015021-pol2qm74 2320 11 anti anti JJ cord-015021-pol2qm74 2320 12 - - JJ cord-015021-pol2qm74 2320 13 mitogenic mitogenic JJ cord-015021-pol2qm74 2320 14 effect effect NN cord-015021-pol2qm74 2320 15 of of IN cord-015021-pol2qm74 2320 16 NO no DT cord-015021-pol2qm74 2320 17 on on IN cord-015021-pol2qm74 2320 18 vascular vascular JJ cord-015021-pol2qm74 2320 19 smooth smooth JJ cord-015021-pol2qm74 2320 20 muscle muscle NN cord-015021-pol2qm74 2320 21 cells cell NNS cord-015021-pol2qm74 2320 22 , , , cord-015021-pol2qm74 2320 23 allowing allow VBG cord-015021-pol2qm74 2320 24 the the DT cord-015021-pol2qm74 2320 25 endothelium endothelium NN cord-015021-pol2qm74 2320 26 to to TO cord-015021-pol2qm74 2320 27 regenerate regenerate VB cord-015021-pol2qm74 2320 28 without without IN cord-015021-pol2qm74 2320 29 intimal intimal JJ cord-015021-pol2qm74 2320 30 thickening thickening NN cord-015021-pol2qm74 2320 31 . . . cord-015021-pol2qm74 2321 1 NO no RB cord-015021-pol2qm74 2321 2 also also RB cord-015021-pol2qm74 2321 3 has have VBZ cord-015021-pol2qm74 2321 4 been be VBN cord-015021-pol2qm74 2321 5 shown show VBN cord-015021-pol2qm74 2321 6 to to TO cord-015021-pol2qm74 2321 7 inhibit inhibit VB cord-015021-pol2qm74 2321 8 platelet platelet NN cord-015021-pol2qm74 2321 9 aggregation aggregation NN cord-015021-pol2qm74 2321 10 , , , cord-015021-pol2qm74 2321 11 and and CC cord-015021-pol2qm74 2321 12 to to TO cord-015021-pol2qm74 2321 13 attenuate attenuate VB cord-015021-pol2qm74 2321 14 neutrophil neutrophil NN cord-015021-pol2qm74 2321 15 adherence adherence NN cord-015021-pol2qm74 2321 16 and and CC cord-015021-pol2qm74 2321 17 activation activation NN cord-015021-pol2qm74 2321 18 . . . cord-015021-pol2qm74 2322 1 The the DT cord-015021-pol2qm74 2322 2 superoxide superoxide NN cord-015021-pol2qm74 2322 3 scavenging scavenging NN cord-015021-pol2qm74 2322 4 effect effect NN cord-015021-pol2qm74 2322 5 of of IN cord-015021-pol2qm74 2322 6 NO no DT cord-015021-pol2qm74 2322 7 is be VBZ cord-015021-pol2qm74 2322 8 not not RB cord-015021-pol2qm74 2322 9 the the DT cord-015021-pol2qm74 2322 10 basis basis NN cord-015021-pol2qm74 2322 11 for for IN cord-015021-pol2qm74 2322 12 these these DT cord-015021-pol2qm74 2322 13 effects effect NNS cord-015021-pol2qm74 2322 14 since since IN cord-015021-pol2qm74 2322 15 hSOD hSOD NNP cord-015021-pol2qm74 2322 16 is be VBZ cord-015021-pol2qm74 2322 17 inactive inactive JJ cord-015021-pol2qm74 2322 18 in in IN cord-015021-pol2qm74 2322 19 preserving preserve VBG cord-015021-pol2qm74 2322 20 endothelial endothelial JJ cord-015021-pol2qm74 2322 21 function function NN cord-015021-pol2qm74 2322 22 in in IN cord-015021-pol2qm74 2322 23 injured injure VBN cord-015021-pol2qm74 2322 24 arteries artery NNS cord-015021-pol2qm74 2322 25 . . . cord-015021-pol2qm74 2323 1 Thus thus RB cord-015021-pol2qm74 2323 2 , , , cord-015021-pol2qm74 2323 3 NO no DT cord-015021-pol2qm74 2323 4 exerts exert VBZ cord-015021-pol2qm74 2323 5 a a DT cord-015021-pol2qm74 2323 6 variety variety NN cord-015021-pol2qm74 2323 7 of of IN cord-015021-pol2qm74 2323 8 cytoprotective cytoprotective JJ cord-015021-pol2qm74 2323 9 effects effect NNS cord-015021-pol2qm74 2323 10 which which WDT cord-015021-pol2qm74 2323 11 may may MD cord-015021-pol2qm74 2323 12 be be VB cord-015021-pol2qm74 2323 13 of of IN cord-015021-pol2qm74 2323 14 importance importance NN cord-015021-pol2qm74 2323 15 in in IN cord-015021-pol2qm74 2323 16 protecting protect VBG cord-015021-pol2qm74 2323 17 against against IN cord-015021-pol2qm74 2323 18 vascular vascular JJ cord-015021-pol2qm74 2323 19 injury injury NN cord-015021-pol2qm74 2323 20 . . . cord-015021-pol2qm74 2324 1 Much much JJ cord-015021-pol2qm74 2324 2 evidence evidence NN cord-015021-pol2qm74 2324 3 has have VBZ cord-015021-pol2qm74 2324 4 now now RB cord-015021-pol2qm74 2324 5 accumulated accumulate VBN cord-015021-pol2qm74 2324 6 to to TO cord-015021-pol2qm74 2324 7 show show VB cord-015021-pol2qm74 2324 8 that that IN cord-015021-pol2qm74 2324 9 the the DT cord-015021-pol2qm74 2324 10 excess excess JJ cord-015021-pol2qm74 2324 11 production production NN cord-015021-pol2qm74 2324 12 of of IN cord-015021-pol2qm74 2324 13 the the DT cord-015021-pol2qm74 2324 14 vasodilator vasodilator NN cord-015021-pol2qm74 2324 15 nitric nitric NN cord-015021-pol2qm74 2324 16 oxide oxide NN cord-015021-pol2qm74 2324 17 ( ( -LRB- cord-015021-pol2qm74 2324 18 NO no UH cord-015021-pol2qm74 2324 19 ) ) -RRB- cord-015021-pol2qm74 2324 20 in in IN cord-015021-pol2qm74 2324 21 sepsis sepsis NN cord-015021-pol2qm74 2324 22 is be VBZ cord-015021-pol2qm74 2324 23 an an DT cord-015021-pol2qm74 2324 24 important important JJ cord-015021-pol2qm74 2324 25 contributor contributor NN cord-015021-pol2qm74 2324 26 to to IN cord-015021-pol2qm74 2324 27 the the DT cord-015021-pol2qm74 2324 28 hypotension hypotension NN cord-015021-pol2qm74 2324 29 and and CC cord-015021-pol2qm74 2324 30 multiorgan multiorgan NN cord-015021-pol2qm74 2324 31 failure failure NN cord-015021-pol2qm74 2324 32 characteristic characteristic JJ cord-015021-pol2qm74 2324 33 of of IN cord-015021-pol2qm74 2324 34 this this DT cord-015021-pol2qm74 2324 35 condition condition NN cord-015021-pol2qm74 2324 36 . . . cord-015021-pol2qm74 2325 1 Various various JJ cord-015021-pol2qm74 2325 2 cytokines cytokine NNS cord-015021-pol2qm74 2325 3 play play VBP cord-015021-pol2qm74 2325 4 an an DT cord-015021-pol2qm74 2325 5 important important JJ cord-015021-pol2qm74 2325 6 role role NN cord-015021-pol2qm74 2325 7 in in IN cord-015021-pol2qm74 2325 8 this this DT cord-015021-pol2qm74 2325 9 process process NN cord-015021-pol2qm74 2325 10 through through IN cord-015021-pol2qm74 2325 11 their -PRON- PRP$ cord-015021-pol2qm74 2325 12 ability ability NN cord-015021-pol2qm74 2325 13 to to TO cord-015021-pol2qm74 2325 14 induce induce VB cord-015021-pol2qm74 2325 15 the the DT cord-015021-pol2qm74 2325 16 production production NN cord-015021-pol2qm74 2325 17 of of IN cord-015021-pol2qm74 2325 18 one one CD cord-015021-pol2qm74 2325 19 of of IN cord-015021-pol2qm74 2325 20 the the DT cord-015021-pol2qm74 2325 21 enzymes enzyme NNS cord-015021-pol2qm74 2325 22 responsible responsible JJ cord-015021-pol2qm74 2325 23 for for IN cord-015021-pol2qm74 2325 24 NO no DT cord-015021-pol2qm74 2325 25 synthesis synthesis NN cord-015021-pol2qm74 2325 26 , , , cord-015021-pol2qm74 2325 27 the the DT cord-015021-pol2qm74 2325 28 inducible inducible JJ cord-015021-pol2qm74 2325 29 NO no DT cord-015021-pol2qm74 2325 30 synthase synthase NN cord-015021-pol2qm74 2325 31 ( ( -LRB- cord-015021-pol2qm74 2325 32 iNOS inos NN cord-015021-pol2qm74 2325 33 ) ) -RRB- cord-015021-pol2qm74 2325 34 . . . cord-015021-pol2qm74 2326 1 We -PRON- PRP cord-015021-pol2qm74 2326 2 have have VBP cord-015021-pol2qm74 2326 3 studied study VBN cord-015021-pol2qm74 2326 4 the the DT cord-015021-pol2qm74 2326 5 effects effect NNS cord-015021-pol2qm74 2326 6 of of IN cord-015021-pol2qm74 2326 7 cytokines cytokine NNS cord-015021-pol2qm74 2326 8 on on IN cord-015021-pol2qm74 2326 9 the the DT cord-015021-pol2qm74 2326 10 induction induction NN cord-015021-pol2qm74 2326 11 of of IN cord-015021-pol2qm74 2326 12 this this DT cord-015021-pol2qm74 2326 13 enzyme enzyme NN cord-015021-pol2qm74 2326 14 both both DT cord-015021-pol2qm74 2326 15 in in IN cord-015021-pol2qm74 2326 16 vitro vitro FW cord-015021-pol2qm74 2326 17 using use VBG cord-015021-pol2qm74 2326 18 vascular vascular JJ cord-015021-pol2qm74 2326 19 smooth smooth JJ cord-015021-pol2qm74 2326 20 muscle muscle NN cord-015021-pol2qm74 2326 21 cells cell NNS cord-015021-pol2qm74 2326 22 , , , cord-015021-pol2qm74 2326 23 and and CC cord-015021-pol2qm74 2326 24 in in IN cord-015021-pol2qm74 2326 25 a a DT cord-015021-pol2qm74 2326 26 murine murine JJ cord-015021-pol2qm74 2326 27 model model NN cord-015021-pol2qm74 2326 28 of of IN cord-015021-pol2qm74 2326 29 Gram gram NN cord-015021-pol2qm74 2326 30 - - HYPH cord-015021-pol2qm74 2326 31 negative negative JJ cord-015021-pol2qm74 2326 32 sepsis sepsis NN cord-015021-pol2qm74 2326 33 . . . cord-015021-pol2qm74 2327 1 tn tn NNP cord-015021-pol2qm74 2327 2 smooth smooth JJ cord-015021-pol2qm74 2327 3 muscle muscle NN cord-015021-pol2qm74 2327 4 ceils ceil NNS cord-015021-pol2qm74 2327 5 , , , cord-015021-pol2qm74 2327 6 the the DT cord-015021-pol2qm74 2327 7 cytokines cytokine NNS cord-015021-pol2qm74 2327 8 IL-1 IL-1 NNP cord-015021-pol2qm74 2327 9 , , , cord-015021-pol2qm74 2327 10 IFNq IFNq NNS cord-015021-pol2qm74 2327 11 ' ' '' cord-015021-pol2qm74 2327 12 , , , cord-015021-pol2qm74 2327 13 and and CC cord-015021-pol2qm74 2327 14 TNF TNF NNP cord-015021-pol2qm74 2327 15 - - HYPH cord-015021-pol2qm74 2327 16 oc oc NNP cord-015021-pol2qm74 2327 17 show show VBP cord-015021-pol2qm74 2327 18 strong strong JJ cord-015021-pol2qm74 2327 19 synergy synergy NN cord-015021-pol2qm74 2327 20 with with IN cord-015021-pol2qm74 2327 21 one one CD cord-015021-pol2qm74 2327 22 another another DT cord-015021-pol2qm74 2327 23 in in IN cord-015021-pol2qm74 2327 24 the the DT cord-015021-pol2qm74 2327 25 production production NN cord-015021-pol2qm74 2327 26 of of IN cord-015021-pol2qm74 2327 27 iNOS inos NN cord-015021-pol2qm74 2327 28 . . . cord-015021-pol2qm74 2328 1 In in IN cord-015021-pol2qm74 2328 2 order order NN cord-015021-pol2qm74 2328 3 to to TO cord-015021-pol2qm74 2328 4 define define VB cord-015021-pol2qm74 2328 5 the the DT cord-015021-pol2qm74 2328 6 molecular molecular JJ cord-015021-pol2qm74 2328 7 basis basis NN cord-015021-pol2qm74 2328 8 for for IN cord-015021-pol2qm74 2328 9 this this DT cord-015021-pol2qm74 2328 10 synergic synergic JJ cord-015021-pol2qm74 2328 11 effect effect NN cord-015021-pol2qm74 2328 12 , , , cord-015021-pol2qm74 2328 13 we -PRON- PRP cord-015021-pol2qm74 2328 14 have have VBP cord-015021-pol2qm74 2328 15 linked link VBN cord-015021-pol2qm74 2328 16 the the DT cord-015021-pol2qm74 2328 17 promoter promoter NN cord-015021-pol2qm74 2328 18 of of IN cord-015021-pol2qm74 2328 19 the the DT cord-015021-pol2qm74 2328 20 iNOS inos JJ cord-015021-pol2qm74 2328 21 gene gene NN cord-015021-pol2qm74 2328 22 to to IN cord-015021-pol2qm74 2328 23 a a DT cord-015021-pol2qm74 2328 24 " " `` cord-015021-pol2qm74 2328 25 reporter reporter NN cord-015021-pol2qm74 2328 26 " " '' cord-015021-pol2qm74 2328 27 gene gene NN cord-015021-pol2qm74 2328 28 , , , cord-015021-pol2qm74 2328 29 chloramphenicol chloramphenicol NN cord-015021-pol2qm74 2328 30 acetyl acetyl NN cord-015021-pol2qm74 2328 31 transferase transferase NN cord-015021-pol2qm74 2328 32 ( ( -LRB- cord-015021-pol2qm74 2328 33 CAT CAT NNP cord-015021-pol2qm74 2328 34 ) ) -RRB- cord-015021-pol2qm74 2328 35 , , , cord-015021-pol2qm74 2328 36 and and CC cord-015021-pol2qm74 2328 37 transfected transfecte VBD cord-015021-pol2qm74 2328 38 these these DT cord-015021-pol2qm74 2328 39 constructs construct NNS cord-015021-pol2qm74 2328 40 into into IN cord-015021-pol2qm74 2328 41 vascular vascular JJ cord-015021-pol2qm74 2328 42 smooth smooth JJ cord-015021-pol2qm74 2328 43 muscle muscle NN cord-015021-pol2qm74 2328 44 cells cell NNS cord-015021-pol2qm74 2328 45 . . . cord-015021-pol2qm74 2329 1 Assays assay NNS cord-015021-pol2qm74 2329 2 of of IN cord-015021-pol2qm74 2329 3 CAT cat NN cord-015021-pol2qm74 2329 4 activity activity NN cord-015021-pol2qm74 2329 5 reflect reflect VBP cord-015021-pol2qm74 2329 6 the the DT cord-015021-pol2qm74 2329 7 activity activity NN cord-015021-pol2qm74 2329 8 of of IN cord-015021-pol2qm74 2329 9 the the DT cord-015021-pol2qm74 2329 10 promoter promoter NN cord-015021-pol2qm74 2329 11 in in IN cord-015021-pol2qm74 2329 12 this this DT cord-015021-pol2qm74 2329 13 system system NN cord-015021-pol2qm74 2329 14 , , , cord-015021-pol2qm74 2329 15 and and CC cord-015021-pol2qm74 2329 16 by by IN cord-015021-pol2qm74 2329 17 generating generate VBG cord-015021-pol2qm74 2329 18 sets set NNS cord-015021-pol2qm74 2329 19 of of IN cord-015021-pol2qm74 2329 20 deletion deletion NN cord-015021-pol2qm74 2329 21 mutants mutant NNS cord-015021-pol2qm74 2329 22 of of IN cord-015021-pol2qm74 2329 23 the the DT cord-015021-pol2qm74 2329 24 promoter promoter NN cord-015021-pol2qm74 2329 25 sequence sequence NN cord-015021-pol2qm74 2329 26 we -PRON- PRP cord-015021-pol2qm74 2329 27 have have VBP cord-015021-pol2qm74 2329 28 been be VBN cord-015021-pol2qm74 2329 29 able able JJ cord-015021-pol2qm74 2329 30 to to TO cord-015021-pol2qm74 2329 31 define define VB cord-015021-pol2qm74 2329 32 the the DT cord-015021-pol2qm74 2329 33 area area NN cord-015021-pol2qm74 2329 34 within within IN cord-015021-pol2qm74 2329 35 the the DT cord-015021-pol2qm74 2329 36 promoter promoter NN cord-015021-pol2qm74 2329 37 which which WDT cord-015021-pol2qm74 2329 38 mediates mediate VBZ cord-015021-pol2qm74 2329 39 the the DT cord-015021-pol2qm74 2329 40 synergic synergic JJ cord-015021-pol2qm74 2329 41 effect effect NN cord-015021-pol2qm74 2329 42 of of IN cord-015021-pol2qm74 2329 43 these these DT cord-015021-pol2qm74 2329 44 cytokines cytokine NNS cord-015021-pol2qm74 2329 45 . . . cord-015021-pol2qm74 2330 1 In in IN cord-015021-pol2qm74 2330 2 addition addition NN cord-015021-pol2qm74 2330 3 to to IN cord-015021-pol2qm74 2330 4 stimufatory stimufatory JJ cord-015021-pol2qm74 2330 5 effects effect NNS cord-015021-pol2qm74 2330 6 on on IN cord-015021-pol2qm74 2330 7 iNOS inos JJ cord-015021-pol2qm74 2330 8 production production NN cord-015021-pol2qm74 2330 9 , , , cord-015021-pol2qm74 2330 10 certain certain JJ cord-015021-pol2qm74 2330 11 cytokines cytokine NNS cord-015021-pol2qm74 2330 12 are be VBP cord-015021-pol2qm74 2330 13 able able JJ cord-015021-pol2qm74 2330 14 to to TO cord-015021-pol2qm74 2330 15 down down VB cord-015021-pol2qm74 2330 16 - - HYPH cord-015021-pol2qm74 2330 17 regulate regulate VB cord-015021-pol2qm74 2330 18 the the DT cord-015021-pol2qm74 2330 19 production production NN cord-015021-pol2qm74 2330 20 of of IN cord-015021-pol2qm74 2330 21 iNOS inos NN cord-015021-pol2qm74 2330 22 in in IN cord-015021-pol2qm74 2330 23 vascular vascular JJ cord-015021-pol2qm74 2330 24 smooth smooth JJ cord-015021-pol2qm74 2330 25 muscle muscle NN cord-015021-pol2qm74 2330 26 cells cell NNS cord-015021-pol2qm74 2330 27 , , , cord-015021-pol2qm74 2330 28 and and CC cord-015021-pol2qm74 2330 29 the the DT cord-015021-pol2qm74 2330 30 effects effect NNS cord-015021-pol2qm74 2330 31 of of IN cord-015021-pol2qm74 2330 32 these these DT cord-015021-pol2qm74 2330 33 counterregulatory counterregulatory JJ cord-015021-pol2qm74 2330 34 cytokines cytokine NNS cord-015021-pol2qm74 2330 35 will will MD cord-015021-pol2qm74 2330 36 be be VB cord-015021-pol2qm74 2330 37 discussed discuss VBN cord-015021-pol2qm74 2330 38 . . . cord-015021-pol2qm74 2331 1 The the DT cord-015021-pol2qm74 2331 2 interaction interaction NN cord-015021-pol2qm74 2331 3 of of IN cord-015021-pol2qm74 2331 4 these these DT cord-015021-pol2qm74 2331 5 cytokine cytokine JJ cord-015021-pol2qm74 2331 6 effects effect NNS cord-015021-pol2qm74 2331 7 in in IN cord-015021-pol2qm74 2331 8 the the DT cord-015021-pol2qm74 2331 9 whole whole JJ cord-015021-pol2qm74 2331 10 organism organism NN cord-015021-pol2qm74 2331 11 has have VBZ cord-015021-pol2qm74 2331 12 been be VBN cord-015021-pol2qm74 2331 13 studied study VBN cord-015021-pol2qm74 2331 14 in in IN cord-015021-pol2qm74 2331 15 a a DT cord-015021-pol2qm74 2331 16 murine murine JJ cord-015021-pol2qm74 2331 17 model model NN cord-015021-pol2qm74 2331 18 of of IN cord-015021-pol2qm74 2331 19 Gramnegative Gramnegative NNP cord-015021-pol2qm74 2331 20 sepsis sepsis NN cord-015021-pol2qm74 2331 21 . . . cord-015021-pol2qm74 2332 1 Widespread widespread JJ cord-015021-pol2qm74 2332 2 induction induction NN cord-015021-pol2qm74 2332 3 of of IN cord-015021-pol2qm74 2332 4 iNOS inos NN cord-015021-pol2qm74 2332 5 occurs occur NNS cord-015021-pol2qm74 2332 6 in in IN cord-015021-pol2qm74 2332 7 this this DT cord-015021-pol2qm74 2332 8 model model NN cord-015021-pol2qm74 2332 9 as as IN cord-015021-pol2qm74 2332 10 assayed assay VBN cord-015021-pol2qm74 2332 11 by by IN cord-015021-pol2qm74 2332 12 enzyme enzyme NN cord-015021-pol2qm74 2332 13 activity activity NN cord-015021-pol2qm74 2332 14 and and CC cord-015021-pol2qm74 2332 15 through through IN cord-015021-pol2qm74 2332 16 use use NN cord-015021-pol2qm74 2332 17 of of IN cord-015021-pol2qm74 2332 18 specific specific JJ cord-015021-pol2qm74 2332 19 antisera antisera NN cord-015021-pol2qm74 2332 20 to to IN cord-015021-pol2qm74 2332 21 iNOS inos NN cord-015021-pol2qm74 2332 22 . . . cord-015021-pol2qm74 2333 1 Neutralizing neutralize VBG cord-015021-pol2qm74 2333 2 antibodies antibody NNS cord-015021-pol2qm74 2333 3 to to IN cord-015021-pol2qm74 2333 4 TNF-~ TNF-~ NNP cord-015021-pol2qm74 2333 5 and and CC cord-015021-pol2qm74 2333 6 tFN tFN NNP cord-015021-pol2qm74 2333 7 - - HYPH cord-015021-pol2qm74 2333 8 y y NNP cord-015021-pol2qm74 2333 9 are be VBP cord-015021-pol2qm74 2333 10 both both DT cord-015021-pol2qm74 2333 11 able able JJ cord-015021-pol2qm74 2333 12 to to TO cord-015021-pol2qm74 2333 13 prevent prevent VB cord-015021-pol2qm74 2333 14 death death NN cord-015021-pol2qm74 2333 15 in in IN cord-015021-pol2qm74 2333 16 this this DT cord-015021-pol2qm74 2333 17 model model NN cord-015021-pol2qm74 2333 18 , , , cord-015021-pol2qm74 2333 19 but but CC cord-015021-pol2qm74 2333 20 it -PRON- PRP cord-015021-pol2qm74 2333 21 is be VBZ cord-015021-pol2qm74 2333 22 only only RB cord-015021-pol2qm74 2333 23 the the DT cord-015021-pol2qm74 2333 24 anti anti JJ cord-015021-pol2qm74 2333 25 - - JJ cord-015021-pol2qm74 2333 26 IFN IFN NNP cord-015021-pol2qm74 2333 27 - - HYPH cord-015021-pol2qm74 2333 28 y y NNP cord-015021-pol2qm74 2333 29 which which WDT cord-015021-pol2qm74 2333 30 attenuates attenuate VBZ cord-015021-pol2qm74 2333 31 the the DT cord-015021-pol2qm74 2333 32 induction induction NN cord-015021-pol2qm74 2333 33 of of IN cord-015021-pol2qm74 2333 34 iNOS inos JJ cord-015021-pol2qm74 2333 35 assayed assay VBN cord-015021-pol2qm74 2333 36 in in IN cord-015021-pol2qm74 2333 37 the the DT cord-015021-pol2qm74 2333 38 liver liver NN cord-015021-pol2qm74 2333 39 . . . cord-015021-pol2qm74 2334 1 Clearly clearly RB cord-015021-pol2qm74 2334 2 there there EX cord-015021-pol2qm74 2334 3 is be VBZ cord-015021-pol2qm74 2334 4 some some DT cord-015021-pol2qm74 2334 5 redundancy redundancy NN cord-015021-pol2qm74 2334 6 in in IN cord-015021-pol2qm74 2334 7 the the DT cord-015021-pol2qm74 2334 8 effects effect NNS cord-015021-pol2qm74 2334 9 of of IN cord-015021-pol2qm74 2334 10 cytokines cytokine NNS cord-015021-pol2qm74 2334 11 on on IN cord-015021-pol2qm74 2334 12 the the DT cord-015021-pol2qm74 2334 13 production production NN cord-015021-pol2qm74 2334 14 of of IN cord-015021-pol2qm74 2334 15 iNOS inos NN cord-015021-pol2qm74 2334 16 in in IN cord-015021-pol2qm74 2334 17 sepsis sepsis NN cord-015021-pol2qm74 2334 18 , , , cord-015021-pol2qm74 2334 19 and and CC cord-015021-pol2qm74 2334 20 greater great JJR cord-015021-pol2qm74 2334 21 understanding understanding NN cord-015021-pol2qm74 2334 22 of of IN cord-015021-pol2qm74 2334 23 the the DT cord-015021-pol2qm74 2334 24 most most RBS cord-015021-pol2qm74 2334 25 important important JJ cord-015021-pol2qm74 2334 26 factors factor NNS cord-015021-pol2qm74 2334 27 in in IN cord-015021-pol2qm74 2334 28 iNOS inos JJ cord-015021-pol2qm74 2334 29 production production NN cord-015021-pol2qm74 2334 30 is be VBZ cord-015021-pol2qm74 2334 31 required require VBN cord-015021-pol2qm74 2334 32 in in IN cord-015021-pol2qm74 2334 33 order order NN cord-015021-pol2qm74 2334 34 to to TO cord-015021-pol2qm74 2334 35 target target VB cord-015021-pol2qm74 2334 36 anti anti JJ cord-015021-pol2qm74 2334 37 - - JJ cord-015021-pol2qm74 2334 38 cytokine cytokine JJ cord-015021-pol2qm74 2334 39 therapy therapy NN cord-015021-pol2qm74 2334 40 most most RBS cord-015021-pol2qm74 2334 41 appropriately appropriately RB cord-015021-pol2qm74 2334 42 . . . cord-015021-pol2qm74 2334 43 _SP cord-015021-pol2qm74 2335 1 Effects effect NNS cord-015021-pol2qm74 2335 2 of of IN cord-015021-pol2qm74 2335 3 nitric nitric NN cord-015021-pol2qm74 2335 4 oxide oxide NN cord-015021-pol2qm74 2335 5 on on IN cord-015021-pol2qm74 2335 6 hepatocyte hepatocyte NN cord-015021-pol2qm74 2335 7 metabolism metabolism NN cord-015021-pol2qm74 2335 8 in in IN cord-015021-pol2qm74 2335 9 inflammation inflammation NN cord-015021-pol2qm74 2335 10 . . . cord-015021-pol2qm74 2336 1 J. J. NNP cord-015021-pol2qm74 2336 2 Stadler Stadler NNP cord-015021-pol2qm74 2336 3 , , , cord-015021-pol2qm74 2336 4 Department Department NNP cord-015021-pol2qm74 2336 5 of of IN cord-015021-pol2qm74 2336 6 Surgery Surgery NNP cord-015021-pol2qm74 2336 7 , , , cord-015021-pol2qm74 2336 8 TU TU NNP cord-015021-pol2qm74 2336 9 MQnchen MQnchen NNP cord-015021-pol2qm74 2336 10 , , , cord-015021-pol2qm74 2336 11 FRG FRG NNP cord-015021-pol2qm74 2336 12 Hepatocellular Hepatocellular NNP cord-015021-pol2qm74 2336 13 nitric nitric NN cord-015021-pol2qm74 2336 14 oxide oxide NN cord-015021-pol2qm74 2337 1 ( ( -LRB- cord-015021-pol2qm74 2337 2 NO no DT cord-015021-pol2qm74 2337 3 ) ) -RRB- cord-015021-pol2qm74 2337 4 synthesis synthesis NN cord-015021-pol2qm74 2337 5 is be VBZ cord-015021-pol2qm74 2337 6 induced induce VBN cord-015021-pol2qm74 2337 7 by by IN cord-015021-pol2qm74 2337 8 proinflammatory proinflammatory JJ cord-015021-pol2qm74 2337 9 mediators mediator NNS cord-015021-pol2qm74 2337 10 such such JJ cord-015021-pol2qm74 2337 11 as as IN cord-015021-pol2qm74 2337 12 tumor tumor NN cord-015021-pol2qm74 2337 13 necrosis necrosis NN cord-015021-pol2qm74 2337 14 factor factor NN cord-015021-pol2qm74 2337 15 , , , cord-015021-pol2qm74 2337 16 interleukin-1 interleukin-1 NN cord-015021-pol2qm74 2337 17 and and CC cord-015021-pol2qm74 2337 18 interferon interferon NN cord-015021-pol2qm74 2337 19 gamma gamma NN cord-015021-pol2qm74 2337 20 or or CC cord-015021-pol2qm74 2337 21 by by IN cord-015021-pol2qm74 2337 22 bacterial bacterial JJ cord-015021-pol2qm74 2337 23 toxins toxin NNS cord-015021-pol2qm74 2337 24 such such JJ cord-015021-pol2qm74 2337 25 as as IN cord-015021-pol2qm74 2337 26 lipopolysaccharide lipopolysaccharide NN cord-015021-pol2qm74 2337 27 . . . cord-015021-pol2qm74 2338 1 Stimulation stimulation NN cord-015021-pol2qm74 2338 2 of of IN cord-015021-pol2qm74 2338 3 the the DT cord-015021-pol2qm74 2338 4 hepatocytes hepatocyte NNS cord-015021-pol2qm74 2338 5 ( ( -LRB- cord-015021-pol2qm74 2338 6 HC HC NNP cord-015021-pol2qm74 2338 7 ) ) -RRB- cord-015021-pol2qm74 2338 8 with with IN cord-015021-pol2qm74 2338 9 a a DT cord-015021-pol2qm74 2338 10 combination combination NN cord-015021-pol2qm74 2338 11 of of IN cord-015021-pol2qm74 2338 12 these these DT cord-015021-pol2qm74 2338 13 agents agent NNS cord-015021-pol2qm74 2338 14 leads lead VBZ cord-015021-pol2qm74 2338 15 to to IN cord-015021-pol2qm74 2338 16 an an DT cord-015021-pol2qm74 2338 17 output output NN cord-015021-pol2qm74 2338 18 of of IN cord-015021-pol2qm74 2338 19 NO no DT cord-015021-pol2qm74 2338 20 in in IN cord-015021-pol2qm74 2338 21 quantities quantity NNS cord-015021-pol2qm74 2338 22 which which WDT cord-015021-pol2qm74 2338 23 are be VBP cord-015021-pol2qm74 2338 24 not not RB cord-015021-pol2qm74 2338 25 seen see VBN cord-015021-pol2qm74 2338 26 in in IN cord-015021-pol2qm74 2338 27 any any DT cord-015021-pol2qm74 2338 28 other other JJ cord-015021-pol2qm74 2338 29 celltype celltype NN cord-015021-pol2qm74 2338 30 . . . cord-015021-pol2qm74 2339 1 It -PRON- PRP cord-015021-pol2qm74 2339 2 has have VBZ cord-015021-pol2qm74 2339 3 been be VBN cord-015021-pol2qm74 2339 4 demonstrated demonstrate VBN cord-015021-pol2qm74 2339 5 by by IN cord-015021-pol2qm74 2339 6 various various JJ cord-015021-pol2qm74 2339 7 investigators investigator NNS cord-015021-pol2qm74 2339 8 that that IN cord-015021-pol2qm74 2339 9 important important JJ cord-015021-pol2qm74 2339 10 effects effect NNS cord-015021-pol2qm74 2339 11 of of IN cord-015021-pol2qm74 2339 12 these these DT cord-015021-pol2qm74 2339 13 cytokines cytokine NNS cord-015021-pol2qm74 2339 14 and and CC cord-015021-pol2qm74 2339 15 bacterial bacterial JJ cord-015021-pol2qm74 2339 16 toxins toxin NNS cord-015021-pol2qm74 2339 17 on on IN cord-015021-pol2qm74 2339 18 HC HC NNP cord-015021-pol2qm74 2339 19 metabolism metabolism NN cord-015021-pol2qm74 2339 20 can can MD cord-015021-pol2qm74 2339 21 be be VB cord-015021-pol2qm74 2339 22 attributed attribute VBN cord-015021-pol2qm74 2339 23 to to IN cord-015021-pol2qm74 2339 24 the the DT cord-015021-pol2qm74 2339 25 action action NN cord-015021-pol2qm74 2339 26 of of IN cord-015021-pol2qm74 2339 27 NO no NN cord-015021-pol2qm74 2339 28 . . . cord-015021-pol2qm74 2340 1 In in IN cord-015021-pol2qm74 2340 2 contrast contrast NN cord-015021-pol2qm74 2340 3 to to IN cord-015021-pol2qm74 2340 4 other other JJ cord-015021-pol2qm74 2340 5 celltypes celltype NNS cord-015021-pol2qm74 2340 6 HC HC NNP cord-015021-pol2qm74 2340 7 seem seem VBP cord-015021-pol2qm74 2340 8 to to TO cord-015021-pol2qm74 2340 9 be be VB cord-015021-pol2qm74 2340 10 relatively relatively RB cord-015021-pol2qm74 2340 11 resistant resistant JJ cord-015021-pol2qm74 2340 12 to to IN cord-015021-pol2qm74 2340 13 suppression suppression NN cord-015021-pol2qm74 2340 14 of of IN cord-015021-pol2qm74 2340 15 basic basic JJ cord-015021-pol2qm74 2340 16 metabolic metabolic JJ cord-015021-pol2qm74 2340 17 functions function NNS cord-015021-pol2qm74 2340 18 such such JJ cord-015021-pol2qm74 2340 19 as as IN cord-015021-pol2qm74 2340 20 energy energy NN cord-015021-pol2qm74 2340 21 metabolism metabolism NN cord-015021-pol2qm74 2340 22 by by IN cord-015021-pol2qm74 2340 23 NO no NN cord-015021-pol2qm74 2340 24 . . . cord-015021-pol2qm74 2341 1 Therefore therefore RB cord-015021-pol2qm74 2341 2 , , , cord-015021-pol2qm74 2341 3 cell cell NN cord-015021-pol2qm74 2341 4 damage damage NN cord-015021-pol2qm74 2341 5 has have VBZ cord-015021-pol2qm74 2341 6 not not RB cord-015021-pol2qm74 2341 7 been be VBN cord-015021-pol2qm74 2341 8 described describe VBN cord-015021-pol2qm74 2341 9 to to IN cord-015021-pol2qm74 2341 10 a a DT cord-015021-pol2qm74 2341 11 significant significant JJ cord-015021-pol2qm74 2341 12 extent extent NN cord-015021-pol2qm74 2341 13 following follow VBG cord-015021-pol2qm74 2341 14 exposure exposure NN cord-015021-pol2qm74 2341 15 to to IN cord-015021-pol2qm74 2341 16 NO no NN cord-015021-pol2qm74 2341 17 . . . cord-015021-pol2qm74 2342 1 However however RB cord-015021-pol2qm74 2342 2 , , , cord-015021-pol2qm74 2342 3 NO NO NNP cord-015021-pol2qm74 2342 4 does do VBZ cord-015021-pol2qm74 2342 5 inhibit inhibit VB cord-015021-pol2qm74 2342 6 total total JJ cord-015021-pol2qm74 2342 7 protein protein NN cord-015021-pol2qm74 2342 8 synthesis synthesis NN cord-015021-pol2qm74 2342 9 . . . cord-015021-pol2qm74 2343 1 The the DT cord-015021-pol2qm74 2343 2 exact exact JJ cord-015021-pol2qm74 2343 3 biochemical biochemical JJ cord-015021-pol2qm74 2343 4 mechanism mechanism NN cord-015021-pol2qm74 2343 5 of of IN cord-015021-pol2qm74 2343 6 this this DT cord-015021-pol2qm74 2343 7 phenomenon phenomenon NN cord-015021-pol2qm74 2343 8 has have VBZ cord-015021-pol2qm74 2343 9 not not RB cord-015021-pol2qm74 2343 10 been be VBN cord-015021-pol2qm74 2343 11 uncovered uncover VBN cord-015021-pol2qm74 2343 12 yet yet RB cord-015021-pol2qm74 2343 13 , , , cord-015021-pol2qm74 2343 14 but but CC cord-015021-pol2qm74 2343 15 it -PRON- PRP cord-015021-pol2qm74 2343 16 has have VBZ cord-015021-pol2qm74 2343 17 been be VBN cord-015021-pol2qm74 2343 18 demonstrated demonstrate VBN cord-015021-pol2qm74 2343 19 for for IN cord-015021-pol2qm74 2343 20 some some DT cord-015021-pol2qm74 2343 21 specific specific JJ cord-015021-pol2qm74 2343 22 proteins protein NNS cord-015021-pol2qm74 2343 23 that that IN cord-015021-pol2qm74 2343 24 their -PRON- PRP$ cord-015021-pol2qm74 2343 25 production production NN cord-015021-pol2qm74 2343 26 is be VBZ cord-015021-pol2qm74 2343 27 inhibited inhibit VBN cord-015021-pol2qm74 2343 28 at at IN cord-015021-pol2qm74 2343 29 a a DT cord-015021-pol2qm74 2343 30 posttransscriptional posttransscriptional JJ cord-015021-pol2qm74 2343 31 level level NN cord-015021-pol2qm74 2343 32 . . . cord-015021-pol2qm74 2344 1 As as IN cord-015021-pol2qm74 2344 2 in in IN cord-015021-pol2qm74 2344 3 many many JJ cord-015021-pol2qm74 2344 4 other other JJ cord-015021-pol2qm74 2344 5 celltypes celltype NNS cord-015021-pol2qm74 2344 6 cGMP cGMP NNP cord-015021-pol2qm74 2344 7 generation generation NN cord-015021-pol2qm74 2344 8 is be VBZ cord-015021-pol2qm74 2344 9 elevated elevate VBN cord-015021-pol2qm74 2344 10 in in IN cord-015021-pol2qm74 2344 11 HC HC NNP cord-015021-pol2qm74 2344 12 by by IN cord-015021-pol2qm74 2344 13 NO no DT cord-015021-pol2qm74 2344 14 through through IN cord-015021-pol2qm74 2344 15 activation activation NN cord-015021-pol2qm74 2344 16 of of IN cord-015021-pol2qm74 2344 17 the the DT cord-015021-pol2qm74 2344 18 soluble soluble JJ cord-015021-pol2qm74 2344 19 guanylate guanylate NN cord-015021-pol2qm74 2344 20 cyclase cyclase NN cord-015021-pol2qm74 2344 21 . . . cord-015021-pol2qm74 2345 1 Cyclic cyclic JJ cord-015021-pol2qm74 2345 2 GMP GMP NNP cord-015021-pol2qm74 2345 3 may may MD cord-015021-pol2qm74 2345 4 possibly possibly RB cord-015021-pol2qm74 2345 5 exert exert VB cord-015021-pol2qm74 2345 6 a a DT cord-015021-pol2qm74 2345 7 plethora plethora NN cord-015021-pol2qm74 2345 8 of of IN cord-015021-pol2qm74 2345 9 metabolic metabolic JJ cord-015021-pol2qm74 2345 10 functions function NNS cord-015021-pol2qm74 2345 11 , , , cord-015021-pol2qm74 2345 12 but but CC cord-015021-pol2qm74 2345 13 it -PRON- PRP cord-015021-pol2qm74 2345 14 is be VBZ cord-015021-pol2qm74 2345 15 interesting interesting JJ cord-015021-pol2qm74 2345 16 to to TO cord-015021-pol2qm74 2345 17 note note VB cord-015021-pol2qm74 2345 18 that that IN cord-015021-pol2qm74 2345 19 most most JJS cord-015021-pol2qm74 2345 20 of of IN cord-015021-pol2qm74 2345 21 the the DT cord-015021-pol2qm74 2345 22 cGMP cGMP NNP cord-015021-pol2qm74 2345 23 seems seem VBZ cord-015021-pol2qm74 2345 24 to to TO cord-015021-pol2qm74 2345 25 be be VB cord-015021-pol2qm74 2345 26 transported transport VBN cord-015021-pol2qm74 2345 27 out out IN cord-015021-pol2qm74 2345 28 of of IN cord-015021-pol2qm74 2345 29 the the DT cord-015021-pol2qm74 2345 30 cell cell NN cord-015021-pol2qm74 2345 31 . . . cord-015021-pol2qm74 2346 1 Some some DT cord-015021-pol2qm74 2346 2 very very RB cord-015021-pol2qm74 2346 3 specific specific JJ cord-015021-pol2qm74 2346 4 effects effect NNS cord-015021-pol2qm74 2346 5 of of IN cord-015021-pol2qm74 2346 6 NO no NN cord-015021-pol2qm74 2346 7 on on IN cord-015021-pol2qm74 2346 8 HC HC NNP cord-015021-pol2qm74 2346 9 metabolism metabolism NN cord-015021-pol2qm74 2346 10 include include VBP cord-015021-pol2qm74 2346 11 the the DT cord-015021-pol2qm74 2346 12 inhibition inhibition NN cord-015021-pol2qm74 2346 13 of of IN cord-015021-pol2qm74 2346 14 the the DT cord-015021-pol2qm74 2346 15 glyceraldehyde-3-phosphate glyceraldehyde-3-phosphate NNP cord-015021-pol2qm74 2346 16 dehydrogenase dehydrogenase NN cord-015021-pol2qm74 2346 17 ( ( -LRB- cord-015021-pol2qm74 2346 18 GAPDH GAPDH NNP cord-015021-pol2qm74 2346 19 ) ) -RRB- cord-015021-pol2qm74 2346 20 and and CC cord-015021-pol2qm74 2346 21 the the DT cord-015021-pol2qm74 2346 22 cytochrome cytochrome NN cord-015021-pol2qm74 2346 23 P450 p450 NN cord-015021-pol2qm74 2346 24 ( ( -LRB- cord-015021-pol2qm74 2346 25 CYP CYP NNP cord-015021-pol2qm74 2346 26 ) ) -RRB- cord-015021-pol2qm74 2346 27 enzymes enzyme NNS cord-015021-pol2qm74 2346 28 . . . cord-015021-pol2qm74 2347 1 Inhibition inhibition NN cord-015021-pol2qm74 2347 2 of of IN cord-015021-pol2qm74 2347 3 GAPDH GAPDH NNP cord-015021-pol2qm74 2347 4 activity activity NN cord-015021-pol2qm74 2347 5 is be VBZ cord-015021-pol2qm74 2347 6 mediated mediate VBN cord-015021-pol2qm74 2347 7 through through IN cord-015021-pol2qm74 2347 8 nitrosylation nitrosylation NN cord-015021-pol2qm74 2347 9 of of IN cord-015021-pol2qm74 2347 10 critical critical JJ cord-015021-pol2qm74 2347 11 domains domain NNS cord-015021-pol2qm74 2347 12 of of IN cord-015021-pol2qm74 2347 13 the the DT cord-015021-pol2qm74 2347 14 enzymes enzyme NNS cord-015021-pol2qm74 2347 15 by by IN cord-015021-pol2qm74 2347 16 NO no DT cord-015021-pol2qm74 2347 17 which which WDT cord-015021-pol2qm74 2347 18 enhances enhance VBZ cord-015021-pol2qm74 2347 19 auto auto NN cord-015021-pol2qm74 2347 20 - - HYPH cord-015021-pol2qm74 2347 21 ADPribosylation adpribosylation NN cord-015021-pol2qm74 2347 22 . . . cord-015021-pol2qm74 2348 1 This this DT cord-015021-pol2qm74 2348 2 effect effect NN cord-015021-pol2qm74 2348 3 on on IN cord-015021-pol2qm74 2348 4 GAPDH GAPDH NNP cord-015021-pol2qm74 2348 5 activity activity NN cord-015021-pol2qm74 2348 6 might may MD cord-015021-pol2qm74 2348 7 be be VB cord-015021-pol2qm74 2348 8 responsible responsible JJ cord-015021-pol2qm74 2348 9 for for IN cord-015021-pol2qm74 2348 10 the the DT cord-015021-pol2qm74 2348 11 inhibition inhibition NN cord-015021-pol2qm74 2348 12 of of IN cord-015021-pol2qm74 2348 13 gluconeogenesis gluconeogenesis NN cord-015021-pol2qm74 2348 14 by by IN cord-015021-pol2qm74 2348 15 NO NO NNP cord-015021-pol2qm74 2348 16 , , , cord-015021-pol2qm74 2348 17 which which WDT cord-015021-pol2qm74 2348 18 has have VBZ cord-015021-pol2qm74 2348 19 been be VBN cord-015021-pol2qm74 2348 20 described describe VBN cord-015021-pol2qm74 2348 21 recently recently RB cord-015021-pol2qm74 2348 22 . . . cord-015021-pol2qm74 2349 1 Finally finally RB cord-015021-pol2qm74 2349 2 , , , cord-015021-pol2qm74 2349 3 NO no RB cord-015021-pol2qm74 2349 4 - - HYPH cord-015021-pol2qm74 2349 5 mediated mediate VBN cord-015021-pol2qm74 2349 6 inhibition inhibition NN cord-015021-pol2qm74 2349 7 of of IN cord-015021-pol2qm74 2349 8 CYPs cyps NN cord-015021-pol2qm74 2349 9 may may MD cord-015021-pol2qm74 2349 10 help help VB cord-015021-pol2qm74 2349 11 to to TO cord-015021-pol2qm74 2349 12 explain explain VB cord-015021-pol2qm74 2349 13 the the DT cord-015021-pol2qm74 2349 14 suppression suppression NN cord-015021-pol2qm74 2349 15 of of IN cord-015021-pol2qm74 2349 16 hiotransformation hiotransformation NN cord-015021-pol2qm74 2349 17 processes process NNS cord-015021-pol2qm74 2349 18 which which WDT cord-015021-pol2qm74 2349 19 is be VBZ cord-015021-pol2qm74 2349 20 a a DT cord-015021-pol2qm74 2349 21 characteristic characteristic JJ cord-015021-pol2qm74 2349 22 featur,'~ featur,'~ NN cord-015021-pol2qm74 2349 23 r r NN cord-015021-pol2qm74 2350 1 ~ ~ NFP cord-015021-pol2qm74 2350 2 " " `` cord-015021-pol2qm74 2350 3 ~flamed ~flame VBN cord-015021-pol2qm74 2351 1 liver liver NN cord-015021-pol2qm74 2351 2 . . . cord-015021-pol2qm74 2352 1 Nitric nitric NN cord-015021-pol2qm74 2352 2 oxide oxide NN cord-015021-pol2qm74 2352 3 ( ( -LRB- cord-015021-pol2qm74 2352 4 NO no UH cord-015021-pol2qm74 2352 5 ) ) -RRB- cord-015021-pol2qm74 2352 6 is be VBZ cord-015021-pol2qm74 2352 7 an an DT cord-015021-pol2qm74 2352 8 endogenous endogenous JJ cord-015021-pol2qm74 2352 9 inhibitor inhibitor NN cord-015021-pol2qm74 2352 10 of of IN cord-015021-pol2qm74 2352 11 polymorphonuclear polymorphonuclear JJ cord-015021-pol2qm74 2352 12 leukocyte leukocyte NN cord-015021-pol2qm74 2352 13 ( ( -LRB- cord-015021-pol2qm74 2352 14 PMN PMN NNP cord-015021-pol2qm74 2352 15 ) ) -RRB- cord-015021-pol2qm74 2352 16 adhesion adhesion NN cord-015021-pol2qm74 2352 17 which which WDT cord-015021-pol2qm74 2352 18 limits limit VBZ cord-015021-pol2qm74 2352 19 PMN pmn NN cord-015021-pol2qm74 2352 20 - - HYPH cord-015021-pol2qm74 2352 21 endothelial endothelial JJ cord-015021-pol2qm74 2352 22 cell cell NN cord-015021-pol2qm74 2352 23 interactions interaction NNS cord-015021-pol2qm74 2352 24 under under IN cord-015021-pol2qm74 2352 25 normal normal JJ cord-015021-pol2qm74 2352 26 conditions condition NNS cord-015021-pol2qm74 2352 27 . . . cord-015021-pol2qm74 2353 1 We -PRON- PRP cord-015021-pol2qm74 2353 2 have have VBP cord-015021-pol2qm74 2353 3 previously previously RB cord-015021-pol2qm74 2353 4 demonstrated demonstrate VBN cord-015021-pol2qm74 2353 5 that that IN cord-015021-pol2qm74 2353 6 following follow VBG cord-015021-pol2qm74 2353 7 ischemia ischemia NN cord-015021-pol2qm74 2353 8 , , , cord-015021-pol2qm74 2353 9 NO no DT cord-015021-pol2qm74 2353 10 production production NN cord-015021-pol2qm74 2353 11 by by IN cord-015021-pol2qm74 2353 12 the the DT cord-015021-pol2qm74 2353 13 vascular vascular JJ cord-015021-pol2qm74 2353 14 endothelinm endothelinm NNP cord-015021-pol2qm74 2353 15 is be VBZ cord-015021-pol2qm74 2353 16 dramatically dramatically RB cord-015021-pol2qm74 2353 17 reduced reduce VBN cord-015021-pol2qm74 2353 18 . . . cord-015021-pol2qm74 2354 1 Accordingly accordingly RB cord-015021-pol2qm74 2354 2 , , , cord-015021-pol2qm74 2354 3 we -PRON- PRP cord-015021-pol2qm74 2354 4 investigated investigate VBD cord-015021-pol2qm74 2354 5 the the DT cord-015021-pol2qm74 2354 6 effects effect NNS cord-015021-pol2qm74 2354 7 of of IN cord-015021-pol2qm74 2354 8 NO NO NNP cord-015021-pol2qm74 2354 9 - - HYPH cord-015021-pol2qm74 2354 10 Donors donor NNS cord-015021-pol2qm74 2354 11 on on IN cord-015021-pol2qm74 2354 12 PMN PMN NNP cord-015021-pol2qm74 2354 13 accumulation accumulation NN cord-015021-pol2qm74 2354 14 and and CC cord-015021-pol2qm74 2354 15 tissue tissue NN cord-015021-pol2qm74 2354 16 injury injury NN cord-015021-pol2qm74 2354 17 following follow VBG cord-015021-pol2qm74 2354 18 hemorrhagic hemorrhagic JJ cord-015021-pol2qm74 2354 19 shock shock NN cord-015021-pol2qm74 2354 20 and and CC cord-015021-pol2qm74 2354 21 ischemia ischemia NN cord-015021-pol2qm74 2354 22 . . . cord-015021-pol2qm74 2355 1 Hemorrhagic hemorrhagic JJ cord-015021-pol2qm74 2355 2 shock shock NN cord-015021-pol2qm74 2355 3 was be VBD cord-015021-pol2qm74 2355 4 induced induce VBN cord-015021-pol2qm74 2355 5 in in IN cord-015021-pol2qm74 2355 6 anesthetized anesthetized JJ cord-015021-pol2qm74 2355 7 rats rat NNS cord-015021-pol2qm74 2355 8 by by IN cord-015021-pol2qm74 2355 9 bleeding bleed VBG cord-015021-pol2qm74 2355 10 to to IN cord-015021-pol2qm74 2355 11 35 35 CD cord-015021-pol2qm74 2355 12 mmHg mmHg NNS cord-015021-pol2qm74 2355 13 for for IN cord-015021-pol2qm74 2355 14 3 3 CD cord-015021-pol2qm74 2355 15 hours hour NNS cord-015021-pol2qm74 2355 16 followed follow VBN cord-015021-pol2qm74 2355 17 by by IN cord-015021-pol2qm74 2355 18 reperfusion reperfusion NN cord-015021-pol2qm74 2355 19 . . . cord-015021-pol2qm74 2356 1 Segments segment NNS cord-015021-pol2qm74 2356 2 of of IN cord-015021-pol2qm74 2356 3 superior superior JJ cord-015021-pol2qm74 2356 4 mesenteric mesenteric JJ cord-015021-pol2qm74 2356 5 artery artery NN cord-015021-pol2qm74 2356 6 ( ( -LRB- cord-015021-pol2qm74 2356 7 SMA SMA NNP cord-015021-pol2qm74 2356 8 ) ) -RRB- cord-015021-pol2qm74 2356 9 were be VBD cord-015021-pol2qm74 2356 10 isolated isolate VBN cord-015021-pol2qm74 2356 11 and and CC cord-015021-pol2qm74 2356 12 suspended suspend VBN cord-015021-pol2qm74 2356 13 in in IN cord-015021-pol2qm74 2356 14 organ organ NN cord-015021-pol2qm74 2356 15 baths bath NNS cord-015021-pol2qm74 2356 16 . . . cord-015021-pol2qm74 2357 1 In in IN cord-015021-pol2qm74 2357 2 rats rat NNS cord-015021-pol2qm74 2357 3 receiving receive VBG cord-015021-pol2qm74 2357 4 saline saline JJ cord-015021-pol2qm74 2357 5 SMA sma JJ cord-015021-pol2qm74 2357 6 relaxation relaxation NN cord-015021-pol2qm74 2357 7 to to IN cord-015021-pol2qm74 2357 8 acetylcholine acetylcholine NN cord-015021-pol2qm74 2357 9 ( ( -LRB- cord-015021-pol2qm74 2357 10 ACh ACh NNP cord-015021-pol2qm74 2357 11 , , , cord-015021-pol2qm74 2357 12 100 100 CD cord-015021-pol2qm74 2357 13 nM nm NN cord-015021-pol2qm74 2357 14 ) ) -RRB- cord-015021-pol2qm74 2357 15 was be VBD cord-015021-pol2qm74 2357 16 reduced reduce VBN cord-015021-pol2qm74 2357 17 by by IN cord-015021-pol2qm74 2357 18 80 80 CD cord-015021-pol2qm74 2357 19 % % NN cord-015021-pol2qm74 2357 20 compared compare VBN cord-015021-pol2qm74 2357 21 to to TO cord-015021-pol2qm74 2357 22 control control VB cord-015021-pol2qm74 2357 23 SMA sma JJ cord-015021-pol2qm74 2357 24 segments segment NNS cord-015021-pol2qm74 2357 25 ( ( -LRB- cord-015021-pol2qm74 2357 26 p<0.01 p<0.01 NNP cord-015021-pol2qm74 2357 27 ) ) -RRB- cord-015021-pol2qm74 2357 28 while while IN cord-015021-pol2qm74 2357 29 relaxation relaxation NN cord-015021-pol2qm74 2357 30 to to IN cord-015021-pol2qm74 2357 31 sodium sodium NN cord-015021-pol2qm74 2357 32 nitrite nitrite NN cord-015021-pol2qm74 2357 33 ( ( -LRB- cord-015021-pol2qm74 2357 34 100 100 CD cord-015021-pol2qm74 2357 35 gM gm NN cord-015021-pol2qm74 2357 36 ) ) -RRB- cord-015021-pol2qm74 2357 37 was be VBD cord-015021-pol2qm74 2357 38 unaffected unaffected JJ cord-015021-pol2qm74 2357 39 . . . cord-015021-pol2qm74 2358 1 In in IN cord-015021-pol2qm74 2358 2 addition addition NN cord-015021-pol2qm74 2358 3 , , , cord-015021-pol2qm74 2358 4 mesenteric mesenteric JJ cord-015021-pol2qm74 2358 5 tissue tissue NN cord-015021-pol2qm74 2358 6 PMN PMN NNP cord-015021-pol2qm74 2358 7 accumulation accumulation NN cord-015021-pol2qm74 2358 8 as as IN cord-015021-pol2qm74 2358 9 determined determine VBN cord-015021-pol2qm74 2358 10 by by IN cord-015021-pol2qm74 2358 11 myeloperoxidase myeloperoxidase NNP cord-015021-pol2qm74 2358 12 ( ( -LRB- cord-015021-pol2qm74 2358 13 MPO MPO NNP cord-015021-pol2qm74 2358 14 ) ) -RRB- cord-015021-pol2qm74 2358 15 activity activity NN cord-015021-pol2qm74 2358 16 was be VBD cord-015021-pol2qm74 2358 17 significantly significantly RB cord-015021-pol2qm74 2358 18 elevated elevate VBN cord-015021-pol2qm74 2358 19 compared compare VBN cord-015021-pol2qm74 2358 20 to to IN cord-015021-pol2qm74 2358 21 controls control NNS cord-015021-pol2qm74 2358 22 ( ( -LRB- cord-015021-pol2qm74 2358 23 p<0.0l p<0.0l NNP cord-015021-pol2qm74 2358 24 ) ) -RRB- cord-015021-pol2qm74 2358 25 . . . cord-015021-pol2qm74 2359 1 Interestingly interestingly RB cord-015021-pol2qm74 2359 2 , , , cord-015021-pol2qm74 2359 3 treatment treatment NN cord-015021-pol2qm74 2359 4 with with IN cord-015021-pol2qm74 2359 5 the the DT cord-015021-pol2qm74 2359 6 NO no RB cord-015021-pol2qm74 2359 7 - - HYPH cord-015021-pol2qm74 2359 8 donating donate VBG cord-015021-pol2qm74 2359 9 agent agent NN cord-015021-pol2qm74 2359 10 , , , cord-015021-pol2qm74 2359 11 S S NNP cord-015021-pol2qm74 2359 12 - - HYPH cord-015021-pol2qm74 2359 13 nitroso nitroso NNP cord-015021-pol2qm74 2359 14 - - HYPH cord-015021-pol2qm74 2359 15 N N NNP cord-015021-pol2qm74 2359 16 - - HYPH cord-015021-pol2qm74 2359 17 acetylpenicillamine acetylpenicillamine NNP cord-015021-pol2qm74 2359 18 ( ( -LRB- cord-015021-pol2qm74 2359 19 SNAP snap VB cord-015021-pol2qm74 2359 20 ) ) -RRB- cord-015021-pol2qm74 2359 21 significantly significantly RB cord-015021-pol2qm74 2359 22 preserved preserve VBN cord-015021-pol2qm74 2359 23 SMA sma JJ cord-015021-pol2qm74 2359 24 relaxation relaxation NN cord-015021-pol2qm74 2359 25 ( ( -LRB- cord-015021-pol2qm74 2359 26 p<0.01 p<0.01 NNP cord-015021-pol2qm74 2359 27 ) ) -RRB- cord-015021-pol2qm74 2359 28 , , , cord-015021-pol2qm74 2359 29 attenuated attenuated JJ cord-015021-pol2qm74 2359 30 mesenteric mesenteric JJ cord-015021-pol2qm74 2359 31 MPO MPO NNP cord-015021-pol2qm74 2359 32 ( ( -LRB- cord-015021-pol2qm74 2359 33 p<0.05 p<0.05 CD cord-015021-pol2qm74 2359 34 ) ) -RRB- cord-015021-pol2qm74 2359 35 activity activity NN cord-015021-pol2qm74 2359 36 , , , cord-015021-pol2qm74 2359 37 and and CC cord-015021-pol2qm74 2359 38 significantly significantly RB cord-015021-pol2qm74 2359 39 improved improve VBN cord-015021-pol2qm74 2359 40 survival survival NN cord-015021-pol2qm74 2359 41 compared compare VBN cord-015021-pol2qm74 2359 42 to to IN cord-015021-pol2qm74 2359 43 saline saline NN cord-015021-pol2qm74 2359 44 vehicle vehicle NN cord-015021-pol2qm74 2359 45 . . . cord-015021-pol2qm74 2360 1 In in IN cord-015021-pol2qm74 2360 2 anesthetized anesthetized JJ cord-015021-pol2qm74 2360 3 , , , cord-015021-pol2qm74 2360 4 open open JJ cord-015021-pol2qm74 2360 5 - - HYPH cord-015021-pol2qm74 2360 6 chest chest NN cord-015021-pol2qm74 2360 7 dogs dog NNS cord-015021-pol2qm74 2360 8 we -PRON- PRP cord-015021-pol2qm74 2360 9 investigated investigate VBD cord-015021-pol2qm74 2360 10 the the DT cord-015021-pol2qm74 2360 11 cardioprotective cardioprotective JJ cord-015021-pol2qm74 2360 12 actions action NNS cord-015021-pol2qm74 2360 13 of of IN cord-015021-pol2qm74 2360 14 a a DT cord-015021-pol2qm74 2360 15 novel novel JJ cord-015021-pol2qm74 2360 16 NO NO NNP cord-015021-pol2qm74 2360 17 - - HYPH cord-015021-pol2qm74 2360 18 Donor Donor NNP cord-015021-pol2qm74 2360 19 , , , cord-015021-pol2qm74 2360 20 SPM-5185 SPM-5185 NNP cord-015021-pol2qm74 2360 21 ( ( -LRB- cord-015021-pol2qm74 2360 22 Schwarz Schwarz NNP cord-015021-pol2qm74 2360 23 Pharma Pharma NNP cord-015021-pol2qm74 2360 24 ) ) -RRB- cord-015021-pol2qm74 2360 25 , , , cord-015021-pol2qm74 2360 26 following follow VBG cord-015021-pol2qm74 2360 27 regional regional JJ cord-015021-pol2qm74 2360 28 myocardial myocardial JJ cord-015021-pol2qm74 2360 29 ischemia ischemia NN cord-015021-pol2qm74 2360 30 ( ( -LRB- cord-015021-pol2qm74 2360 31 1 1 CD cord-015021-pol2qm74 2360 32 hour hour NN cord-015021-pol2qm74 2360 33 ) ) -RRB- cord-015021-pol2qm74 2360 34 and and CC cord-015021-pol2qm74 2360 35 reperfusion reperfusion NN cord-015021-pol2qm74 2360 36 ( ( -LRB- cord-015021-pol2qm74 2360 37 4.5 4.5 CD cord-015021-pol2qm74 2360 38 hours hour NNS cord-015021-pol2qm74 2360 39 ) ) -RRB- cord-015021-pol2qm74 2360 40 . . . cord-015021-pol2qm74 2361 1 Treatment treatment NN cord-015021-pol2qm74 2361 2 with with IN cord-015021-pol2qm74 2361 3 SPM-5185 SPM-5185 NNPS cord-015021-pol2qm74 2361 4 ( ( -LRB- cord-015021-pol2qm74 2361 5 500 500 CD cord-015021-pol2qm74 2361 6 riM rim CD cord-015021-pol2qm74 2361 7 ) ) -RRB- cord-015021-pol2qm74 2361 8 significantly significantly RB cord-015021-pol2qm74 2361 9 reduced reduce VBN cord-015021-pol2qm74 2361 10 myocardial myocardial JJ cord-015021-pol2qm74 2361 11 necrosis necrosis NN cord-015021-pol2qm74 2361 12 by by IN cord-015021-pol2qm74 2361 13 70 70 CD cord-015021-pol2qm74 2361 14 % % NN cord-015021-pol2qm74 2361 15 ( ( -LRB- cord-015021-pol2qm74 2361 16 p<0.01 p<0.01 NNP cord-015021-pol2qm74 2361 17 ) ) -RRB- cord-015021-pol2qm74 2361 18 compared compare VBN cord-015021-pol2qm74 2361 19 to to IN cord-015021-pol2qm74 2361 20 an an DT cord-015021-pol2qm74 2361 21 NO no RB cord-015021-pol2qm74 2361 22 - - HYPH cord-015021-pol2qm74 2361 23 deficient deficient JJ cord-015021-pol2qm74 2361 24 analog analog NN cord-015021-pol2qm74 2361 25 of of IN cord-015021-pol2qm74 2361 26 SPM-5185 SPM-5185 NNP cord-015021-pol2qm74 2361 27 , , , cord-015021-pol2qm74 2361 28 SPM-5267 SPM-5267 NNP cord-015021-pol2qm74 2361 29 . . . cord-015021-pol2qm74 2362 1 Furthermore furthermore RB cord-015021-pol2qm74 2362 2 , , , cord-015021-pol2qm74 2362 3 MPO MPO NNP cord-015021-pol2qm74 2362 4 activity activity NN cord-015021-pol2qm74 2362 5 within within IN cord-015021-pol2qm74 2362 6 the the DT cord-015021-pol2qm74 2362 7 ischemic ischemic JJ cord-015021-pol2qm74 2362 8 - - HYPH cord-015021-pol2qm74 2362 9 reperfused reperfused JJ cord-015021-pol2qm74 2362 10 zone zone NN cord-015021-pol2qm74 2362 11 was be VBD cord-015021-pol2qm74 2362 12 also also RB cord-015021-pol2qm74 2362 13 significantly significantly RB cord-015021-pol2qm74 2362 14 ( ( -LRB- cord-015021-pol2qm74 2362 15 p<0.01 p<0.01 JJ cord-015021-pol2qm74 2362 16 ) ) -RRB- cord-015021-pol2qm74 2362 17 reduced reduce VBN cord-015021-pol2qm74 2362 18 following follow VBG cord-015021-pol2qm74 2362 19 treatment treatment NN cord-015021-pol2qm74 2362 20 with with IN cord-015021-pol2qm74 2362 21 SPM-5185 SPM-5185 NNPS cord-015021-pol2qm74 2362 22 compared compare VBN cord-015021-pol2qm74 2362 23 to to IN cord-015021-pol2qm74 2362 24 SPM-5267 SPM-5267 NNP cord-015021-pol2qm74 2362 25 ( ( -LRB- cord-015021-pol2qm74 2362 26 1.6 1.6 CD cord-015021-pol2qm74 2362 27 + + SYM cord-015021-pol2qm74 2362 28 0.5 0.5 CD cord-015021-pol2qm74 2362 29 vs. vs. CC cord-015021-pol2qm74 2362 30 3.8 3.8 CD cord-015021-pol2qm74 2362 31 + + SYM cord-015021-pol2qm74 2362 32 0.3 0.3 CD cord-015021-pol2qm74 2362 33 U/100 U/100 NNS cord-015021-pol2qm74 2362 34 mg mg CD cord-015021-pol2qm74 2362 35 tissue tissue NN cord-015021-pol2qm74 2362 36 ) ) -RRB- cord-015021-pol2qm74 2362 37 . . . cord-015021-pol2qm74 2363 1 These these DT cord-015021-pol2qm74 2363 2 data datum NNS cord-015021-pol2qm74 2363 3 strongly strongly RB cord-015021-pol2qm74 2363 4 suggest suggest VBP cord-015021-pol2qm74 2363 5 that that IN cord-015021-pol2qm74 2363 6 NO no DT cord-015021-pol2qm74 2363 7 is be VBZ cord-015021-pol2qm74 2363 8 a a DT cord-015021-pol2qm74 2363 9 potent potent JJ cord-015021-pol2qm74 2363 10 inhibitor inhibitor NN cord-015021-pol2qm74 2363 11 of of IN cord-015021-pol2qm74 2363 12 PMN pmn NN cord-015021-pol2qm74 2363 13 - - HYPH cord-015021-pol2qm74 2363 14 mediated mediate VBN cord-015021-pol2qm74 2363 15 tissue tissue NN cord-015021-pol2qm74 2363 16 injury injury NN cord-015021-pol2qm74 2363 17 following follow VBG cord-015021-pol2qm74 2363 18 hemorrhagic hemorrhagic JJ cord-015021-pol2qm74 2363 19 shock shock NN cord-015021-pol2qm74 2363 20 as as RB cord-015021-pol2qm74 2363 21 well well RB cord-015021-pol2qm74 2363 22 as as IN cord-015021-pol2qm74 2363 23 in in IN cord-015021-pol2qm74 2363 24 acute acute JJ cord-015021-pol2qm74 2363 25 myocardial myocardial JJ cord-015021-pol2qm74 2363 26 ischemia ischemia NN cord-015021-pol2qm74 2363 27 - - HYPH cord-015021-pol2qm74 2363 28 reperfusion reperfusion NN cord-015021-pol2qm74 2363 29 injury injury NN cord-015021-pol2qm74 2363 30 . . . cord-015021-pol2qm74 2364 1 Overproduction overproduction NN cord-015021-pol2qm74 2364 2 of of IN cord-015021-pol2qm74 2364 3 nitdc nitdc NNS cord-015021-pol2qm74 2364 4 oxide oxide NN cord-015021-pol2qm74 2364 5 ( ( -LRB- cord-015021-pol2qm74 2364 6 NO no UH cord-015021-pol2qm74 2364 7 ' ' '' cord-015021-pol2qm74 2364 8 ) ) -RRB- cord-015021-pol2qm74 2364 9 may may MD cord-015021-pol2qm74 2364 10 contribute contribute VB cord-015021-pol2qm74 2364 11 to to IN cord-015021-pol2qm74 2364 12 sepsis sepsis NN cord-015021-pol2qm74 2364 13 - - HYPH cord-015021-pol2qm74 2364 14 induced induce VBN cord-015021-pol2qm74 2364 15 hypotension hypotension NN cord-015021-pol2qm74 2364 16 . . . cord-015021-pol2qm74 2365 1 During during IN cord-015021-pol2qm74 2365 2 septic septic JJ cord-015021-pol2qm74 2365 3 shock shock NN cord-015021-pol2qm74 2365 4 , , , cord-015021-pol2qm74 2365 5 excess excess JJ cord-015021-pol2qm74 2365 6 NO no NN cord-015021-pol2qm74 2365 7 " " '' cord-015021-pol2qm74 2365 8 is be VBZ cord-015021-pol2qm74 2365 9 produced produce VBN cord-015021-pol2qm74 2365 10 by by IN cord-015021-pol2qm74 2365 11 an an DT cord-015021-pol2qm74 2365 12 isoform isoform NN cord-015021-pol2qm74 2365 13 of of IN cord-015021-pol2qm74 2365 14 nitric nitric JJ cord-015021-pol2qm74 2365 15 oxide oxide NN cord-015021-pol2qm74 2365 16 synthase synthase NN cord-015021-pol2qm74 2365 17 ( ( -LRB- cord-015021-pol2qm74 2365 18 NOS NOS NNP cord-015021-pol2qm74 2365 19 ) ) -RRB- cord-015021-pol2qm74 2365 20 which which WDT cord-015021-pol2qm74 2365 21 is be VBZ cord-015021-pol2qm74 2365 22 induced induce VBN cord-015021-pol2qm74 2365 23 by by IN cord-015021-pol2qm74 2365 24 inflammatory inflammatory JJ cord-015021-pol2qm74 2365 25 mediators mediator NNS cord-015021-pol2qm74 2365 26 . . . cord-015021-pol2qm74 2366 1 Nonselective nonselective JJ cord-015021-pol2qm74 2366 2 NOS NOS NNP cord-015021-pol2qm74 2366 3 inhibitors inhibitor NNS cord-015021-pol2qm74 2366 4 have have VBP cord-015021-pol2qm74 2366 5 been be VBN cord-015021-pol2qm74 2366 6 proposed propose VBN cord-015021-pol2qm74 2366 7 as as IN cord-015021-pol2qm74 2366 8 a a DT cord-015021-pol2qm74 2366 9 new new JJ cord-015021-pol2qm74 2366 10 therapeutic therapeutic JJ cord-015021-pol2qm74 2366 11 approach approach NN cord-015021-pol2qm74 2366 12 to to IN cord-015021-pol2qm74 2366 13 treating treat VBG cord-015021-pol2qm74 2366 14 hypotension hypotension NN cord-015021-pol2qm74 2366 15 in in IN cord-015021-pol2qm74 2366 16 septic septic JJ cord-015021-pol2qm74 2366 17 shock shock NN cord-015021-pol2qm74 2366 18 . . . cord-015021-pol2qm74 2367 1 We -PRON- PRP cord-015021-pol2qm74 2367 2 studied study VBD cord-015021-pol2qm74 2367 3 the the DT cord-015021-pol2qm74 2367 4 differential differential JJ cord-015021-pol2qm74 2367 5 hemodynamic hemodynamic JJ cord-015021-pol2qm74 2367 6 effects effect NNS cord-015021-pol2qm74 2367 7 of of IN cord-015021-pol2qm74 2367 8 N~-methyI N~-methyI NNP cord-015021-pol2qm74 2367 9 - - HYPH cord-015021-pol2qm74 2367 10 L l NN cord-015021-pol2qm74 2367 11 - - HYPH cord-015021-pol2qm74 2367 12 arginine arginine NN cord-015021-pol2qm74 2367 13 ( ( -LRB- cord-015021-pol2qm74 2367 14 L L NNP cord-015021-pol2qm74 2367 15 - - HYPH cord-015021-pol2qm74 2367 16 NMA NMA NNP cord-015021-pol2qm74 2367 17 ) ) -RRB- cord-015021-pol2qm74 2367 18 , , , cord-015021-pol2qm74 2367 19 a a DT cord-015021-pol2qm74 2367 20 NOS NOS NNP cord-015021-pol2qm74 2367 21 inhibitor inhibitor NN cord-015021-pol2qm74 2367 22 , , , cord-015021-pol2qm74 2367 23 in in IN cord-015021-pol2qm74 2367 24 normal normal JJ cord-015021-pol2qm74 2367 25 canines canine NNS cord-015021-pol2qm74 2367 26 versus versus IN cord-015021-pol2qm74 2367 27 those those DT cord-015021-pol2qm74 2367 28 challenged challenge VBN cord-015021-pol2qm74 2367 29 with with IN cord-015021-pol2qm74 2367 30 endotexin endotexin NNP cord-015021-pol2qm74 2367 31 ( ( -LRB- cord-015021-pol2qm74 2367 32 LPS LPS NNP cord-015021-pol2qm74 2367 33 ) ) -RRB- cord-015021-pol2qm74 2367 34 and and CC cord-015021-pol2qm74 2367 35 compared compare VBD cord-015021-pol2qm74 2367 36 the the DT cord-015021-pol2qm74 2367 37 activity activity NN cord-015021-pol2qm74 2367 38 of of IN cord-015021-pol2qm74 2367 39 this this DT cord-015021-pol2qm74 2367 40 drug drug NN cord-015021-pol2qm74 2367 41 across across IN cord-015021-pol2qm74 2367 42 the the DT cord-015021-pol2qm74 2367 43 venous venous JJ cord-015021-pol2qm74 2367 44 , , , cord-015021-pol2qm74 2367 45 pulmonary pulmonary JJ cord-015021-pol2qm74 2367 46 and and CC cord-015021-pol2qm74 2367 47 systemic systemic JJ cord-015021-pol2qm74 2367 48 vascular vascular JJ cord-015021-pol2qm74 2367 49 beds bed NNS cord-015021-pol2qm74 2367 50 . . . cord-015021-pol2qm74 2368 1 Awake awake JJ cord-015021-pol2qm74 2368 2 canines canine NNS cord-015021-pol2qm74 2368 3 were be VBD cord-015021-pol2qm74 2368 4 challenged challenge VBN cord-015021-pol2qm74 2368 5 with with IN cord-015021-pol2qm74 2368 6 LPS LPS NNP cord-015021-pol2qm74 2368 7 ( ( -LRB- cord-015021-pol2qm74 2368 8 0 0 NFP cord-015021-pol2qm74 2368 9 mg mg NNP cord-015021-pol2qm74 2368 10 / / SYM cord-015021-pol2qm74 2368 11 kg kg NNP cord-015021-pol2qm74 2368 12 , , , cord-015021-pol2qm74 2368 13 n=15:8 n=15:8 NNP cord-015021-pol2qm74 2368 14 mg mg NNP cord-015021-pol2qm74 2368 15 / / SYM cord-015021-pol2qm74 2368 16 kg kg NNP cord-015021-pol2qm74 2368 17 , , , cord-015021-pol2qm74 2368 18 n=21 n=21 NN cord-015021-pol2qm74 2368 19 ; ; : cord-015021-pol2qm74 2368 20 or or CC cord-015021-pol2qm74 2368 21 16 16 CD cord-015021-pol2qm74 2368 22 mg mg NNP cord-015021-pol2qm74 2368 23 / / SYM cord-015021-pol2qm74 2368 24 kg kg NNP cord-015021-pol2qm74 2368 25 , , , cord-015021-pol2qm74 2368 26 n=30 n=30 NNP cord-015021-pol2qm74 2368 27 ) ) -RRB- cord-015021-pol2qm74 2368 28 and and CC cord-015021-pol2qm74 2368 29 treated treat VBN cord-015021-pol2qm74 2368 30 with with IN cord-015021-pol2qm74 2368 31 L L NNP cord-015021-pol2qm74 2368 32 - - HYPH cord-015021-pol2qm74 2368 33 NMA NMA NNP cord-015021-pol2qm74 2368 34 ( ( -LRB- cord-015021-pol2qm74 2368 35 0 0 NFP cord-015021-pol2qm74 2368 36 , , , cord-015021-pol2qm74 2368 37 1,2 1,2 CD cord-015021-pol2qm74 2368 38 , , , cord-015021-pol2qm74 2368 39 4,10 4,10 CD cord-015021-pol2qm74 2368 40 mg mg NNP cord-015021-pol2qm74 2368 41 / / SYM cord-015021-pol2qm74 2368 42 kg kg NNP cord-015021-pol2qm74 2368 43 / / SYM cord-015021-pol2qm74 2368 44 hr hr NN cord-015021-pol2qm74 2368 45 ) ) -RRB- cord-015021-pol2qm74 2368 46 for for IN cord-015021-pol2qm74 2368 47 22 22 CD cord-015021-pol2qm74 2368 48 hours hour NNS cord-015021-pol2qm74 2368 49 following follow VBG cord-015021-pol2qm74 2368 50 a a DT cord-015021-pol2qm74 2368 51 0 0 CD cord-015021-pol2qm74 2368 52 , , , cord-015021-pol2qm74 2368 53 10 10 CD cord-015021-pol2qm74 2368 54 , , , cord-015021-pol2qm74 2368 55 or40 or40 NNP cord-015021-pol2qm74 2368 56 mg mg NNP cord-015021-pol2qm74 2368 57 / / SYM cord-015021-pol2qm74 2368 58 kg kg NNP cord-015021-pol2qm74 2368 59 loading loading NN cord-015021-pol2qm74 2368 60 dose dose NN cord-015021-pol2qm74 2368 61 . . . cord-015021-pol2qm74 2369 1 Animals animal NNS cord-015021-pol2qm74 2369 2 were be VBD cord-015021-pol2qm74 2369 3 resuscitated resuscitate VBN cord-015021-pol2qm74 2369 4 with with IN cord-015021-pol2qm74 2369 5 IV IV NNP cord-015021-pol2qm74 2369 6 Ringers Ringers NNPS cord-015021-pol2qm74 2369 7 solution solution NN cord-015021-pol2qm74 2369 8 ( ( -LRB- cord-015021-pol2qm74 2369 9 10 10 CD cord-015021-pol2qm74 2369 10 ml ml NN cord-015021-pol2qm74 2369 11 / / SYM cord-015021-pol2qm74 2369 12 kg kg NNP cord-015021-pol2qm74 2369 13 / / SYM cord-015021-pol2qm74 2369 14 hr hr NN cord-015021-pol2qm74 2369 15 ) ) -RRB- cord-015021-pol2qm74 2369 16 . . . cord-015021-pol2qm74 2370 1 Hemodynamic Hemodynamic NNP cord-015021-pol2qm74 2370 2 data datum NNS cord-015021-pol2qm74 2370 3 were be VBD cord-015021-pol2qm74 2370 4 collected collect VBN cord-015021-pol2qm74 2370 5 at at IN cord-015021-pol2qm74 2370 6 0 0 CD cord-015021-pol2qm74 2370 7 , , , cord-015021-pol2qm74 2370 8 2 2 CD cord-015021-pol2qm74 2370 9 , , , cord-015021-pol2qm74 2370 10 6 6 CD cord-015021-pol2qm74 2370 11 , , , cord-015021-pol2qm74 2370 12 10 10 CD cord-015021-pol2qm74 2370 13 , , , cord-015021-pol2qm74 2370 14 14 14 CD cord-015021-pol2qm74 2370 15 , , , cord-015021-pol2qm74 2370 16 and and CC cord-015021-pol2qm74 2370 17 22 22 CD cord-015021-pol2qm74 2370 18 hours hour NNS cord-015021-pol2qm74 2370 19 using use VBG cord-015021-pol2qm74 2370 20 intravascular intravascular JJ cord-015021-pol2qm74 2370 21 catheters catheter NNS cord-015021-pol2qm74 2370 22 and and CC cord-015021-pol2qm74 2370 23 radionuclide radionuclide NN cord-015021-pol2qm74 2370 24 heart heart NN cord-015021-pol2qm74 2370 25 scans scan NNS cord-015021-pol2qm74 2370 26 and and CC cord-015021-pol2qm74 2370 27 analyzed analyze VBN cord-015021-pol2qm74 2370 28 by by IN cord-015021-pol2qm74 2370 29 ANOVA ANOVA NNP cord-015021-pol2qm74 2370 30 . . . cord-015021-pol2qm74 2371 1 In in IN cord-015021-pol2qm74 2371 2 both both CC cord-015021-pol2qm74 2371 3 normal normal JJ cord-015021-pol2qm74 2371 4 and and CC cord-015021-pol2qm74 2371 5 endotoxemic endotoxemic JJ cord-015021-pol2qm74 2371 6 animals animal NNS cord-015021-pol2qm74 2371 7 , , , cord-015021-pol2qm74 2371 8 L L NNP cord-015021-pol2qm74 2371 9 - - HYPH cord-015021-pol2qm74 2371 10 NMA NMA NNP cord-015021-pol2qm74 2371 11 at at IN cord-015021-pol2qm74 2371 12 all all DT cord-015021-pol2qm74 2371 13 doses dose NNS cord-015021-pol2qm74 2371 14 studied study VBD cord-015021-pol2qm74 2371 15 similarly similarly RB cord-015021-pol2qm74 2371 16 increased increase VBD cord-015021-pol2qm74 2371 17 mean mean JJ cord-015021-pol2qm74 2371 18 arterial arterial JJ cord-015021-pol2qm74 2371 19 pressure pressure NN cord-015021-pol2qm74 2371 20 ( ( -LRB- cord-015021-pol2qm74 2371 21 p=0.07 p=0.07 NNP cord-015021-pol2qm74 2371 22 ) ) -RRB- cord-015021-pol2qm74 2371 23 , , , cord-015021-pol2qm74 2371 24 and and CC cord-015021-pol2qm74 2371 25 systemic systemic JJ cord-015021-pol2qm74 2371 26 vascular vascular JJ cord-015021-pol2qm74 2371 27 resistance resistance NN cord-015021-pol2qm74 2371 28 index index NN cord-015021-pol2qm74 2371 29 ( ( -LRB- cord-015021-pol2qm74 2371 30 p=0.Ol p=0.ol XX cord-015021-pol2qm74 2371 31 ) ) -RRB- cord-015021-pol2qm74 2371 32 and and CC cord-015021-pol2qm74 2371 33 decreased decrease VBD cord-015021-pol2qm74 2371 34 cardiac cardiac JJ cord-015021-pol2qm74 2371 35 index index NN cord-015021-pol2qm74 2371 36 ( ( -LRB- cord-015021-pol2qm74 2371 37 p=0.05 p=0.05 NNP cord-015021-pol2qm74 2371 38 ) ) -RRB- cord-015021-pol2qm74 2371 39 and and CC cord-015021-pol2qm74 2371 40 oxygen oxygen NN cord-015021-pol2qm74 2371 41 delivery delivery NN cord-015021-pol2qm74 2371 42 index index NN cord-015021-pol2qm74 2371 43 ( ( -LRB- cord-015021-pol2qm74 2371 44 p=0.01 p=0.01 NNP cord-015021-pol2qm74 2371 45 ) ) -RRB- cord-015021-pol2qm74 2371 46 . . . cord-015021-pol2qm74 2372 1 In in IN cord-015021-pol2qm74 2372 2 contrast contrast NN cord-015021-pol2qm74 2372 3 , , , cord-015021-pol2qm74 2372 4 the the DT cord-015021-pol2qm74 2372 5 effect effect NN cord-015021-pol2qm74 2372 6 of of IN cord-015021-pol2qm74 2372 7 L L NNP cord-015021-pol2qm74 2372 8 - - HYPH cord-015021-pol2qm74 2372 9 NMA NMA NNP cord-015021-pol2qm74 2372 10 on on IN cord-015021-pol2qm74 2372 11 mean mean JJ cord-015021-pol2qm74 2372 12 pulmonary pulmonary JJ cord-015021-pol2qm74 2372 13 artery artery NN cord-015021-pol2qm74 2372 14 pressure pressure NN cord-015021-pol2qm74 2372 15 , , , cord-015021-pol2qm74 2372 16 central central JJ cord-015021-pol2qm74 2372 17 venous venous JJ cord-015021-pol2qm74 2372 18 pressure pressure NN cord-015021-pol2qm74 2372 19 , , , cord-015021-pol2qm74 2372 20 pulmonary pulmonary JJ cord-015021-pol2qm74 2372 21 capillary capillary JJ cord-015021-pol2qm74 2372 22 wedge wedge NN cord-015021-pol2qm74 2372 23 pressure pressure NN cord-015021-pol2qm74 2372 24 , , , cord-015021-pol2qm74 2372 25 and and CC cord-015021-pol2qm74 2372 26 pulmonary pulmonary JJ cord-015021-pol2qm74 2372 27 vascular vascular JJ cord-015021-pol2qm74 2372 28 resistance resistance NN cord-015021-pol2qm74 2372 29 index index NN cord-015021-pol2qm74 2372 30 was be VBD cord-015021-pol2qm74 2372 31 greater great JJR cord-015021-pol2qm74 2372 32 in in IN cord-015021-pol2qm74 2372 33 LPS LPS NNP cord-015021-pol2qm74 2372 34 - - HYPH cord-015021-pol2qm74 2372 35 challenged challenge VBN cord-015021-pol2qm74 2372 36 canines canine NNS cord-015021-pol2qm74 2372 37 compared compare VBN cord-015021-pol2qm74 2372 38 to to IN cord-015021-pol2qm74 2372 39 normal normal JJ cord-015021-pol2qm74 2372 40 animals animal NNS cord-015021-pol2qm74 2372 41 ( ( -LRB- cord-015021-pol2qm74 2372 42 p<0.05 p<0.05 CD cord-015021-pol2qm74 2372 43 ) ) -RRB- cord-015021-pol2qm74 2372 44 , , , cord-015021-pol2qm74 2372 45 but but CC cord-015021-pol2qm74 2372 46 this this DT cord-015021-pol2qm74 2372 47 differential differential JJ cord-015021-pol2qm74 2372 48 effect effect NN cord-015021-pol2qm74 2372 49 on on IN cord-015021-pol2qm74 2372 50 the the DT cord-015021-pol2qm74 2372 51 venous venous JJ cord-015021-pol2qm74 2372 52 and and CC cord-015021-pol2qm74 2372 53 pulmonary pulmonary JJ cord-015021-pol2qm74 2372 54 circulation circulation NN cord-015021-pol2qm74 2372 55 occurred occur VBD cord-015021-pol2qm74 2372 56 , , , cord-015021-pol2qm74 2372 57 > > XX cord-015021-pol2qm74 2372 58 6 6 CD cord-015021-pol2qm74 2372 59 hours hour NNS cord-015021-pol2qm74 2372 60 after after IN cord-015021-pol2qm74 2372 61 LPS LPS NNP cord-015021-pol2qm74 2372 62 challenge challenge NN cord-015021-pol2qm74 2372 63 . . . cord-015021-pol2qm74 2373 1 L L NNP cord-015021-pol2qm74 2373 2 - - HYPH cord-015021-pol2qm74 2373 3 NMA NMA NNP cord-015021-pol2qm74 2373 4 did do VBD cord-015021-pol2qm74 2373 5 not not RB cord-015021-pol2qm74 2373 6 significantly significantly RB cord-015021-pol2qm74 2373 7 increase increase VB cord-015021-pol2qm74 2373 8 survival survival NN cord-015021-pol2qm74 2373 9 rates rate NNS cord-015021-pol2qm74 2373 10 or or CC cord-015021-pol2qm74 2373 11 times time NNS cord-015021-pol2qm74 2373 12 at at IN cord-015021-pol2qm74 2373 13 any any DT cord-015021-pol2qm74 2373 14 of of IN cord-015021-pol2qm74 2373 15 the the DT cord-015021-pol2qm74 2373 16 doses dose NNS cord-015021-pol2qm74 2373 17 studied study VBN cord-015021-pol2qm74 2373 18 ( ( -LRB- cord-015021-pol2qm74 2373 19 1 1 CD cord-015021-pol2qm74 2373 20 , , , cord-015021-pol2qm74 2373 21 2 2 CD cord-015021-pol2qm74 2373 22 , , , cord-015021-pol2qm74 2373 23 4 4 CD cord-015021-pol2qm74 2373 24 , , , cord-015021-pol2qm74 2373 25 or or CC cord-015021-pol2qm74 2373 26 10 10 CD cord-015021-pol2qm74 2373 27 mg mg NNP cord-015021-pol2qm74 2373 28 / / SYM cord-015021-pol2qm74 2373 29 kg kg NNP cord-015021-pol2qm74 2373 30 / / SYM cord-015021-pol2qm74 2373 31 h h NN cord-015021-pol2qm74 2373 32 ) ) -RRB- cord-015021-pol2qm74 2373 33 in in IN cord-015021-pol2qm74 2373 34 either either CC cord-015021-pol2qm74 2373 35 the the DT cord-015021-pol2qm74 2373 36 low low JJ cord-015021-pol2qm74 2373 37 ( ( -LRB- cord-015021-pol2qm74 2373 38 8 8 CD cord-015021-pol2qm74 2373 39 mg mg NNP cord-015021-pol2qm74 2373 40 / / SYM cord-015021-pol2qm74 2373 41 kg kg NNP cord-015021-pol2qm74 2373 42 ) ) -RRB- cord-015021-pol2qm74 2373 43 or or CC cord-015021-pol2qm74 2373 44 high high JJ cord-015021-pol2qm74 2373 45 dose dose NN cord-015021-pol2qm74 2373 46 ( ( -LRB- cord-015021-pol2qm74 2373 47 16 16 CD cord-015021-pol2qm74 2373 48 mg mg NNP cord-015021-pol2qm74 2373 49 / / SYM cord-015021-pol2qm74 2373 50 kg kg NNP cord-015021-pol2qm74 2373 51 ) ) -RRB- cord-015021-pol2qm74 2373 52 LPS LPS NNP cord-015021-pol2qm74 2373 53 - - HYPH cord-015021-pol2qm74 2373 54 challenge challenge NN cord-015021-pol2qm74 2373 55 groups group NNS cord-015021-pol2qm74 2373 56 . . . cord-015021-pol2qm74 2374 1 A a DT cord-015021-pol2qm74 2374 2 nonsignificant nonsignificant JJ cord-015021-pol2qm74 2374 3 ( ( -LRB- cord-015021-pol2qm74 2374 4 p>0.2 p>0.2 JJ cord-015021-pol2qm74 2374 5 ) ) -RRB- cord-015021-pol2qm74 2374 6 trend trend NN cord-015021-pol2qm74 2374 7 toward toward IN cord-015021-pol2qm74 2374 8 a a DT cord-015021-pol2qm74 2374 9 beneficial beneficial JJ cord-015021-pol2qm74 2374 10 effect effect NN cord-015021-pol2qm74 2374 11 on on IN cord-015021-pol2qm74 2374 12 survival survival NN cord-015021-pol2qm74 2374 13 ol old IN cord-015021-pol2qm74 2374 14 low low JJ cord-015021-pol2qm74 2374 15 dose dose NN cord-015021-pol2qm74 2374 16 L L NNP cord-015021-pol2qm74 2374 17 - - HYPH cord-015021-pol2qm74 2374 18 NMA NMA NNP cord-015021-pol2qm74 2374 19 ( ( -LRB- cord-015021-pol2qm74 2374 20 1 1 CD cord-015021-pol2qm74 2374 21 mg mg NNP cord-015021-pol2qm74 2374 22 / / SYM cord-015021-pol2qm74 2374 23 kg kg NNP cord-015021-pol2qm74 2374 24 / / SYM cord-015021-pol2qm74 2374 25 h h NN cord-015021-pol2qm74 2374 26 ) ) -RRB- cord-015021-pol2qm74 2374 27 in in IN cord-015021-pol2qm74 2374 28 animals animal NNS cord-015021-pol2qm74 2375 1 given give VBN cord-015021-pol2qm74 2375 2 the the DT cord-015021-pol2qm74 2375 3 8 8 CD cord-015021-pol2qm74 2375 4 mg mg NNP cord-015021-pol2qm74 2375 5 / / SYM cord-015021-pol2qm74 2375 6 kg kg NNP cord-015021-pol2qm74 2375 7 LPS LPS NNP cord-015021-pol2qm74 2375 8 - - HYPH cord-015021-pol2qm74 2375 9 cha[lenge cha[lenge NNP cord-015021-pol2qm74 2376 1 was be VBD cord-015021-pol2qm74 2376 2 not not RB cord-015021-pol2qm74 2376 3 enhanced enhance VBN cord-015021-pol2qm74 2376 4 by by IN cord-015021-pol2qm74 2376 5 increasing increase VBG cord-015021-pol2qm74 2376 6 the the DT cord-015021-pol2qm74 2376 7 lethality lethality NN cord-015021-pol2qm74 2376 8 of of IN cord-015021-pol2qm74 2376 9 the the DT cord-015021-pol2qm74 2376 10 model model NN cord-015021-pol2qm74 2376 11 or or CC cord-015021-pol2qm74 2376 12 by by IN cord-015021-pol2qm74 2376 13 administering administer VBG cord-015021-pol2qm74 2376 14 higher high JJR cord-015021-pol2qm74 2376 15 L L NNP cord-015021-pol2qm74 2376 16 - - HYPH cord-015021-pol2qm74 2376 17 NMA NMA NNP cord-015021-pol2qm74 2376 18 doses dose NNS cord-015021-pol2qm74 2376 19 . . . cord-015021-pol2qm74 2377 1 At at IN cord-015021-pol2qm74 2377 2 the the DT cord-015021-pol2qm74 2377 3 highest high JJS cord-015021-pol2qm74 2377 4 L L NNP cord-015021-pol2qm74 2377 5 - - HYPH cord-015021-pol2qm74 2377 6 NMA NMA NNP cord-015021-pol2qm74 2377 7 dose dose NN cord-015021-pol2qm74 2377 8 used use VBN cord-015021-pol2qm74 2377 9 in in IN cord-015021-pol2qm74 2377 10 this this DT cord-015021-pol2qm74 2377 11 study study NN cord-015021-pol2qm74 2377 12 ( ( -LRB- cord-015021-pol2qm74 2377 13 10 10 CD cord-015021-pol2qm74 2377 14 mg mg NNP cord-015021-pol2qm74 2377 15 / / SYM cord-015021-pol2qm74 2377 16 kg kg NNP cord-015021-pol2qm74 2377 17 / / SYM cord-015021-pol2qm74 2377 18 h h NNP cord-015021-pol2qm74 2377 19 ) ) -RRB- cord-015021-pol2qm74 2377 20 , , , cord-015021-pol2qm74 2377 21 survival survival NN cord-015021-pol2qm74 2377 22 time time NN cord-015021-pol2qm74 2377 23 decreased decrease VBD cord-015021-pol2qm74 2377 24 significantly significantly RB cord-015021-pol2qm74 2377 25 for for IN cord-015021-pol2qm74 2377 26 both both CC cord-015021-pol2qm74 2377 27 the the DT cord-015021-pol2qm74 2377 28 low low JJ cord-015021-pol2qm74 2377 29 and and CC cord-015021-pol2qm74 2377 30 high high JJ cord-015021-pol2qm74 2377 31 dose dose NN cord-015021-pol2qm74 2377 32 LPS LPS NNP cord-015021-pol2qm74 2377 33 - - HYPH cord-015021-pol2qm74 2377 34 challenge challenge NN cord-015021-pol2qm74 2377 35 animals animal NNS cord-015021-pol2qm74 2377 36 ( ( -LRB- cord-015021-pol2qm74 2377 37 p<0.05 p<0.05 CD cord-015021-pol2qm74 2377 38 ) ) -RRB- cord-015021-pol2qm74 2377 39 . . . cord-015021-pol2qm74 2378 1 This this DT cord-015021-pol2qm74 2378 2 increased increase VBN cord-015021-pol2qm74 2378 3 mortality mortality NN cord-015021-pol2qm74 2378 4 was be VBD cord-015021-pol2qm74 2378 5 not not RB cord-015021-pol2qm74 2378 6 explained explain VBN cord-015021-pol2qm74 2378 7 by by IN cord-015021-pol2qm74 2378 8 changes change NNS cord-015021-pol2qm74 2378 9 in in IN cord-015021-pol2qm74 2378 10 plasma plasma NN cord-015021-pol2qm74 2378 11 concentrations concentration NNS cord-015021-pol2qm74 2378 12 of of IN cord-015021-pol2qm74 2378 13 either either DT cord-015021-pol2qm74 2378 14 LPS LPS NNP cord-015021-pol2qm74 2378 15 or or CC cord-015021-pol2qm74 2378 16 TNFc~. TNFc~. NNP cord-015021-pol2qm74 2379 1 Thus thus RB cord-015021-pol2qm74 2379 2 , , , cord-015021-pol2qm74 2379 3 L L NNP cord-015021-pol2qm74 2379 4 - - HYPH cord-015021-pol2qm74 2379 5 NMA NMA NNP cord-015021-pol2qm74 2379 6 did do VBD cord-015021-pol2qm74 2379 7 not not RB cord-015021-pol2qm74 2379 8 have have VB cord-015021-pol2qm74 2379 9 a a DT cord-015021-pol2qm74 2379 10 greater great JJR cord-015021-pol2qm74 2379 11 effect effect NN cord-015021-pol2qm74 2379 12 on on IN cord-015021-pol2qm74 2379 13 the the DT cord-015021-pol2qm74 2379 14 systemic systemic JJ cord-015021-pol2qm74 2379 15 arterial arterial JJ cord-015021-pol2qm74 2379 16 circulation circulation NN cord-015021-pol2qm74 2379 17 in in IN cord-015021-pol2qm74 2379 18 endotoxemic endotoxemic NNP cord-015021-pol2qm74 2379 19 compared compare VBN cord-015021-pol2qm74 2379 20 to to IN cord-015021-pol2qm74 2379 21 normal normal JJ cord-015021-pol2qm74 2379 22 canines canine NNS cord-015021-pol2qm74 2379 23 . . . cord-015021-pol2qm74 2380 1 However however RB cord-015021-pol2qm74 2380 2 , , , cord-015021-pol2qm74 2380 3 in in IN cord-015021-pol2qm74 2380 4 the the DT cord-015021-pol2qm74 2380 5 venous venous JJ cord-015021-pol2qm74 2380 6 and and CC cord-015021-pol2qm74 2380 7 pulmonary pulmonary JJ cord-015021-pol2qm74 2380 8 vascular vascular JJ cord-015021-pol2qm74 2380 9 beds bed NNS cord-015021-pol2qm74 2380 10 , , , cord-015021-pol2qm74 2380 11 the the DT cord-015021-pol2qm74 2380 12 effect effect NN cord-015021-pol2qm74 2380 13 of of IN cord-015021-pol2qm74 2380 14 L L NNP cord-015021-pol2qm74 2380 15 - - HYPH cord-015021-pol2qm74 2380 16 NMA NMA NNP cord-015021-pol2qm74 2380 17 increased increase VBD cord-015021-pol2qm74 2380 18 with with IN cord-015021-pol2qm74 2380 19 time time NN cord-015021-pol2qm74 2380 20 after after IN cord-015021-pol2qm74 2380 21 endotoxin endotoxin NN cord-015021-pol2qm74 2380 22 - - HYPH cord-015021-pol2qm74 2380 23 challenge challenge NN cord-015021-pol2qm74 2380 24 These these DT cord-015021-pol2qm74 2380 25 data datum NNS cord-015021-pol2qm74 2380 26 suggest suggest VBP cord-015021-pol2qm74 2380 27 the the DT cord-015021-pol2qm74 2380 28 induction induction NN cord-015021-pol2qm74 2380 29 of of IN cord-015021-pol2qm74 2380 30 NOS NOS NNP cord-015021-pol2qm74 2380 31 activity activity NN cord-015021-pol2qm74 2380 32 by by IN cord-015021-pol2qm74 2380 33 endotoxin endotoxin NN cord-015021-pol2qm74 2380 34 in in IN cord-015021-pol2qm74 2380 35 canines canine NNS cord-015021-pol2qm74 2380 36 may may MD cord-015021-pol2qm74 2380 37 be be VB cord-015021-pol2qm74 2380 38 relatively relatively RB cord-015021-pol2qm74 2380 39 greater great JJR cord-015021-pol2qm74 2380 40 in in IN cord-015021-pol2qm74 2380 41 venous venous JJ cord-015021-pol2qm74 2380 42 and and CC cord-015021-pol2qm74 2380 43 pulmonary pulmonary JJ cord-015021-pol2qm74 2380 44 vessels vessel NNS cord-015021-pol2qm74 2380 45 compared compare VBN cord-015021-pol2qm74 2380 46 to to IN cord-015021-pol2qm74 2380 47 systernic systernic JJ cord-015021-pol2qm74 2380 48 arteries artery NNS cord-015021-pol2qm74 2380 49 . . . cord-015021-pol2qm74 2381 1 L L NNP cord-015021-pol2qm74 2381 2 - - HYPH cord-015021-pol2qm74 2381 3 NMA NMA NNP cord-015021-pol2qm74 2381 4 , , , cord-015021-pol2qm74 2381 5 a a DT cord-015021-pol2qm74 2381 6 nonselective nonselective JJ cord-015021-pol2qm74 2381 7 NOS NOS NNP cord-015021-pol2qm74 2381 8 inhibitor inhibitor NN cord-015021-pol2qm74 2381 9 , , , cord-015021-pol2qm74 2381 10 did do VBD cord-015021-pol2qm74 2381 11 not not RB cord-015021-pol2qm74 2381 12 decrease decrease VB cord-015021-pol2qm74 2381 13 mortality mortality NN cord-015021-pol2qm74 2381 14 in in IN cord-015021-pol2qm74 2381 15 endoloxemic endoloxemic JJ cord-015021-pol2qm74 2381 16 canines canines NNPS cord-015021-pol2qm74 2381 17 and and CC cord-015021-pol2qm74 2381 18 the the DT cord-015021-pol2qm74 2381 19 highest high JJS cord-015021-pol2qm74 2381 20 dose dose NN cord-015021-pol2qm74 2381 21 studied study VBN cord-015021-pol2qm74 2381 22 was be VBD cord-015021-pol2qm74 2381 23 harmful harmful JJ cord-015021-pol2qm74 2381 24 . . . cord-015021-pol2qm74 2382 1 Pulmonary pulmonary JJ cord-015021-pol2qm74 2382 2 hypertension hypertension NN cord-015021-pol2qm74 2382 3 ( ( -LRB- cord-015021-pol2qm74 2382 4 PH PH NNP cord-015021-pol2qm74 2382 5 ) ) -RRB- cord-015021-pol2qm74 2382 6 and and CC cord-015021-pol2qm74 2382 7 arterial arterial JJ cord-015021-pol2qm74 2382 8 hypoxemia hypoxemia NN cord-015021-pol2qm74 2382 9 are be VBP cord-015021-pol2qm74 2382 10 characteristic characteristic JJ cord-015021-pol2qm74 2382 11 features feature NNS cord-015021-pol2qm74 2382 12 of of IN cord-015021-pol2qm74 2382 13 the the DT cord-015021-pol2qm74 2382 14 adult adult NN cord-015021-pol2qm74 2382 15 respiratory respiratory JJ cord-015021-pol2qm74 2382 16 distress distress NN cord-015021-pol2qm74 2382 17 syndrome syndrome NN cord-015021-pol2qm74 2382 18 ( ( -LRB- cord-015021-pol2qm74 2382 19 ARDS ARDS NNP cord-015021-pol2qm74 2382 20 ) ) -RRB- cord-015021-pol2qm74 2382 21 . . . cord-015021-pol2qm74 2383 1 Reducing reduce VBG cord-015021-pol2qm74 2383 2 pulmonary pulmonary JJ cord-015021-pol2qm74 2383 3 vascular vascular JJ cord-015021-pol2qm74 2383 4 pressures pressure NNS cord-015021-pol2qm74 2383 5 may may MD cord-015021-pol2qm74 2383 6 promote promote VB cord-015021-pol2qm74 2383 7 the the DT cord-015021-pol2qm74 2383 8 resolution resolution NN cord-015021-pol2qm74 2383 9 of of IN cord-015021-pol2qm74 2383 10 pulmonary pulmonary JJ cord-015021-pol2qm74 2383 11 edema edema NN cord-015021-pol2qm74 2383 12 . . . cord-015021-pol2qm74 2384 1 Intravenously intravenously RB cord-015021-pol2qm74 2384 2 infused infuse VBN cord-015021-pol2qm74 2384 3 vasodilators vasodilator NNS cord-015021-pol2qm74 2384 4 lower low JJR cord-015021-pol2qm74 2384 5 PH PH NNP cord-015021-pol2qm74 2384 6 in in IN cord-015021-pol2qm74 2384 7 ARDS ARDS NNP cord-015021-pol2qm74 2384 8 , , , cord-015021-pol2qm74 2384 9 but but CC cord-015021-pol2qm74 2384 10 , , , cord-015021-pol2qm74 2384 11 as as IN cord-015021-pol2qm74 2384 12 a a DT cord-015021-pol2qm74 2384 13 result result NN cord-015021-pol2qm74 2384 14 of of IN cord-015021-pol2qm74 2384 15 their -PRON- PRP$ cord-015021-pol2qm74 2384 16 general general JJ cord-015021-pol2qm74 2384 17 vasodilatatory vasodilatatory NN cord-015021-pol2qm74 2384 18 effects effect NNS cord-015021-pol2qm74 2384 19 , , , cord-015021-pol2qm74 2384 20 systemic systemic JJ cord-015021-pol2qm74 2384 21 mean mean JJ cord-015021-pol2qm74 2384 22 arterial arterial JJ cord-015021-pol2qm74 2384 23 pressure pressure NN cord-015021-pol2qm74 2384 24 may may MD cord-015021-pol2qm74 2384 25 also also RB cord-015021-pol2qm74 2384 26 decrease decrease VB cord-015021-pol2qm74 2384 27 . . . cord-015021-pol2qm74 2385 1 Furthermore furthermore RB cord-015021-pol2qm74 2385 2 , , , cord-015021-pol2qm74 2385 3 blood blood NN cord-015021-pol2qm74 2385 4 flow flow NN cord-015021-pol2qm74 2385 5 may may MD cord-015021-pol2qm74 2385 6 be be VB cord-015021-pol2qm74 2385 7 increased increase VBN cord-015021-pol2qm74 2385 8 to to IN cord-015021-pol2qm74 2385 9 non non JJ cord-015021-pol2qm74 2385 10 - - JJ cord-015021-pol2qm74 2385 11 ventilated ventilated JJ cord-015021-pol2qm74 2385 12 or or CC cord-015021-pol2qm74 2385 13 poorly poorly RB cord-015021-pol2qm74 2385 14 ventilated ventilate VBN cord-015021-pol2qm74 2385 15 lung lung NN cord-015021-pol2qm74 2385 16 areas area NNS cord-015021-pol2qm74 2385 17 resulting result VBG cord-015021-pol2qm74 2385 18 in in IN cord-015021-pol2qm74 2385 19 a a DT cord-015021-pol2qm74 2385 20 rise rise NN cord-015021-pol2qm74 2385 21 of of IN cord-015021-pol2qm74 2385 22 intrapulmonary intrapulmonary JJ cord-015021-pol2qm74 2385 23 shunt shunt NN cord-015021-pol2qm74 2385 24 , , , cord-015021-pol2qm74 2385 25 thus thus RB cord-015021-pol2qm74 2385 26 causing cause VBG cord-015021-pol2qm74 2385 27 a a DT cord-015021-pol2qm74 2385 28 further further JJ cord-015021-pol2qm74 2385 29 fall fall NN cord-015021-pol2qm74 2385 30 in in IN cord-015021-pol2qm74 2385 31 PaD pad NN cord-015021-pol2qm74 2385 32 2 2 CD cord-015021-pol2qm74 2385 33 . . . cord-015021-pol2qm74 2386 1 Recently recently RB cord-015021-pol2qm74 2386 2 , , , cord-015021-pol2qm74 2386 3 short short JJ cord-015021-pol2qm74 2386 4 term term NN cord-015021-pol2qm74 2386 5 inhalation inhalation NN cord-015021-pol2qm74 2386 6 of of IN cord-015021-pol2qm74 2386 7 low low JJ cord-015021-pol2qm74 2386 8 concentrations concentration NNS cord-015021-pol2qm74 2386 9 of of IN cord-015021-pol2qm74 2386 10 the the DT cord-015021-pol2qm74 2386 11 gas gas NN cord-015021-pol2qm74 2386 12 nitric nitric NN cord-015021-pol2qm74 2386 13 oxide oxide NN cord-015021-pol2qm74 2386 14 ( ( -LRB- cord-015021-pol2qm74 2386 15 NO no UH cord-015021-pol2qm74 2386 16 ) ) -RRB- cord-015021-pol2qm74 2386 17 , , , cord-015021-pol2qm74 2386 18 an an DT cord-015021-pol2qm74 2386 19 endogenous endogenous JJ cord-015021-pol2qm74 2386 20 endothelium endothelium NN cord-015021-pol2qm74 2386 21 derived derive VBN cord-015021-pol2qm74 2386 22 relaxing relax VBG cord-015021-pol2qm74 2386 23 factor factor NN cord-015021-pol2qm74 2386 24 , , , cord-015021-pol2qm74 2386 25 which which WDT cord-015021-pol2qm74 2386 26 is be VBZ cord-015021-pol2qm74 2386 27 rapidly rapidly RB cord-015021-pol2qm74 2386 28 inactivated inactivate VBN cord-015021-pol2qm74 2386 29 in in IN cord-015021-pol2qm74 2386 30 blood blood NN cord-015021-pol2qm74 2386 31 by by IN cord-015021-pol2qm74 2386 32 hemoglobin hemoglobin NN cord-015021-pol2qm74 2386 33 , , , cord-015021-pol2qm74 2386 34 was be VBD cord-015021-pol2qm74 2386 35 reported report VBN cord-015021-pol2qm74 2386 36 to to TO cord-015021-pol2qm74 2386 37 decrease decrease VB cord-015021-pol2qm74 2386 38 PH PH NNP cord-015021-pol2qm74 2386 39 without without IN cord-015021-pol2qm74 2386 40 causing cause VBG cord-015021-pol2qm74 2386 41 systemic systemic JJ cord-015021-pol2qm74 2386 42 vasodilation vasodilation NN cord-015021-pol2qm74 2386 43 in in IN cord-015021-pol2qm74 2386 44 sheep sheep NN cord-015021-pol2qm74 2386 45 [ [ -LRB- cord-015021-pol2qm74 2386 46 1 1 CD cord-015021-pol2qm74 2386 47 ] ] -RRB- cord-015021-pol2qm74 2386 48 . . . cord-015021-pol2qm74 2387 1 Similar similar JJ cord-015021-pol2qm74 2387 2 changes change NNS cord-015021-pol2qm74 2387 3 have have VBP cord-015021-pol2qm74 2387 4 been be VBN cord-015021-pol2qm74 2387 5 observed observe VBN cord-015021-pol2qm74 2387 6 in in IN cord-015021-pol2qm74 2387 7 patients patient NNS cord-015021-pol2qm74 2387 8 with with IN cord-015021-pol2qm74 2387 9 severe severe JJ cord-015021-pol2qm74 2387 10 ARDS ARDS NNP cord-015021-pol2qm74 2387 11 during during IN cord-015021-pol2qm74 2387 12 repeated repeat VBN cord-015021-pol2qm74 2387 13 short short JJ cord-015021-pol2qm74 2387 14 term term NN cord-015021-pol2qm74 2387 15 inhalation inhalation NN cord-015021-pol2qm74 2387 16 of of IN cord-015021-pol2qm74 2387 17 NO NO NNP cord-015021-pol2qm74 2387 18 ( ( -LRB- cord-015021-pol2qm74 2387 19 18 18 CD cord-015021-pol2qm74 2387 20 and and CC cord-015021-pol2qm74 2387 21 36 36 CD cord-015021-pol2qm74 2387 22 ppm ppm NN cord-015021-pol2qm74 2387 23 ) ) -RRB- cord-015021-pol2qm74 2387 24 , , , cord-015021-pol2qm74 2387 25 which which WDT cord-015021-pol2qm74 2387 26 rapidly rapidly RB cord-015021-pol2qm74 2387 27 and and CC cord-015021-pol2qm74 2387 28 selectively selectively RB cord-015021-pol2qm74 2387 29 decreased decrease VBD cord-015021-pol2qm74 2387 30 the the DT cord-015021-pol2qm74 2387 31 mean mean JJ cord-015021-pol2qm74 2387 32 pulmonary pulmonary JJ cord-015021-pol2qm74 2387 33 artery artery NN cord-015021-pol2qm74 2387 34 pressure pressure NN cord-015021-pol2qm74 2387 35 ( ( -LRB- cord-015021-pol2qm74 2387 36 PAP pap NN cord-015021-pol2qm74 2387 37 ) ) -RRB- cord-015021-pol2qm74 2387 38 and and CC cord-015021-pol2qm74 2387 39 , , , cord-015021-pol2qm74 2387 40 in in IN cord-015021-pol2qm74 2387 41 contrast contrast NN cord-015021-pol2qm74 2387 42 to to IN cord-015021-pol2qm74 2387 43 intravenously intravenously RB cord-015021-pol2qm74 2387 44 infused infuse VBN cord-015021-pol2qm74 2387 45 prostacyclin prostacyclin NNP cord-015021-pol2qm74 2387 46 , , , cord-015021-pol2qm74 2387 47 induced induce VBD cord-015021-pol2qm74 2387 48 a a DT cord-015021-pol2qm74 2387 49 remarkable remarkable JJ cord-015021-pol2qm74 2387 50 increase increase NN cord-015021-pol2qm74 2387 51 of of IN cord-015021-pol2qm74 2387 52 PaD2 PaD2 NNS cord-015021-pol2qm74 2387 53 [ [ -LRB- cord-015021-pol2qm74 2387 54 2 2 CD cord-015021-pol2qm74 2387 55 ] ] -RRB- cord-015021-pol2qm74 2387 56 . . . cord-015021-pol2qm74 2388 1 This this DT cord-015021-pol2qm74 2388 2 improvement improvement NN cord-015021-pol2qm74 2388 3 in in IN cord-015021-pol2qm74 2388 4 oxygenation oxygenation NN cord-015021-pol2qm74 2388 5 was be VBD cord-015021-pol2qm74 2388 6 caused cause VBN cord-015021-pol2qm74 2388 7 by by IN cord-015021-pol2qm74 2388 8 a a DT cord-015021-pol2qm74 2388 9 redistribution redistribution NN cord-015021-pol2qm74 2388 10 in in IN cord-015021-pol2qm74 2388 11 blood blood NN cord-015021-pol2qm74 2388 12 flow flow NN cord-015021-pol2qm74 2388 13 away away RB cord-015021-pol2qm74 2388 14 from from IN cord-015021-pol2qm74 2388 15 intrapulmonary intrapulmonary JJ cord-015021-pol2qm74 2388 16 shunt shunt NN cord-015021-pol2qm74 2388 17 areas area NNS cord-015021-pol2qm74 2388 18 to to IN cord-015021-pol2qm74 2388 19 normal normal JJ cord-015021-pol2qm74 2388 20 ventilated ventilate VBN cord-015021-pol2qm74 2388 21 lung lung NN cord-015021-pol2qm74 2388 22 regions region NNS cord-015021-pol2qm74 2388 23 . . . cord-015021-pol2qm74 2389 1 Continuous continuous JJ cord-015021-pol2qm74 2389 2 NO no DT cord-015021-pol2qm74 2389 3 inhalation inhalation NN cord-015021-pol2qm74 2389 4 ( ( -LRB- cord-015021-pol2qm74 2389 5 5 5 CD cord-015021-pol2qm74 2389 6 - - SYM cord-015021-pol2qm74 2389 7 20 20 CD cord-015021-pol2qm74 2389 8 ppm ppm NN cord-015021-pol2qm74 2389 9 ) ) -RRB- cord-015021-pol2qm74 2389 10 consistently consistently RB cord-015021-pol2qm74 2389 11 lowered lower VBD cord-015021-pol2qm74 2389 12 the the DT cord-015021-pol2qm74 2389 13 PAP pap NN cord-015021-pol2qm74 2389 14 and and CC cord-015021-pol2qm74 2389 15 augmented augment VBD cord-015021-pol2qm74 2389 16 the the DT cord-015021-pol2qm74 2389 17 PaO2 PaO2 NNPS cord-015021-pol2qm74 2389 18 / / SYM cord-015021-pol2qm74 2389 19 F.O f.o NN cord-015021-pol2qm74 2389 20 2 2 CD cord-015021-pol2qm74 2389 21 for for IN cord-015021-pol2qm74 2389 22 up up IN cord-015021-pol2qm74 2389 23 to to TO cord-015021-pol2qm74 2389 24 53 53 CD cord-015021-pol2qm74 2389 25 days day NNS cord-015021-pol2qm74 2389 26 . . . cord-015021-pol2qm74 2390 1 No no DT cord-015021-pol2qm74 2390 2 negative negative JJ cord-015021-pol2qm74 2390 3 side side NN cord-015021-pol2qm74 2390 4 effects effect NNS cord-015021-pol2qm74 2390 5 were be VBD cord-015021-pol2qm74 2390 6 observed observe VBN cord-015021-pol2qm74 2390 7 during during IN cord-015021-pol2qm74 2390 8 the the DT cord-015021-pol2qm74 2390 9 whole whole JJ cord-015021-pol2qm74 2390 10 time time NN cord-015021-pol2qm74 2390 11 span span NN cord-015021-pol2qm74 2390 12 examined examine VBN cord-015021-pol2qm74 2390 13 . . . cord-015021-pol2qm74 2391 1 In in IN cord-015021-pol2qm74 2391 2 particular particular JJ cord-015021-pol2qm74 2391 3 methemoglobin methemoglobin JJ cord-015021-pol2qm74 2391 4 levels level NNS cord-015021-pol2qm74 2391 5 always always RB cord-015021-pol2qm74 2391 6 remained remain VBD cord-015021-pol2qm74 2391 7 below below IN cord-015021-pol2qm74 2391 8 1.5 1.5 CD cord-015021-pol2qm74 2391 9 % % NN cord-015021-pol2qm74 2391 10 . . . cord-015021-pol2qm74 2392 1 Following follow VBG cord-015021-pol2qm74 2392 2 these these DT cord-015021-pol2qm74 2392 3 investigations investigation NNS cord-015021-pol2qm74 2392 4 , , , cord-015021-pol2qm74 2392 5 it -PRON- PRP cord-015021-pol2qm74 2392 6 could could MD cord-015021-pol2qm74 2392 7 be be VB cord-015021-pol2qm74 2392 8 shown show VBN cord-015021-pol2qm74 2392 9 that that IN cord-015021-pol2qm74 2392 10 these these DT cord-015021-pol2qm74 2392 11 effects effect NNS cord-015021-pol2qm74 2392 12 may may MD cord-015021-pol2qm74 2392 13 also also RB cord-015021-pol2qm74 2392 14 occur occur VB cord-015021-pol2qm74 2392 15 using use VBG cord-015021-pol2qm74 2392 16 concentrations concentration NNS cord-015021-pol2qm74 2392 17 in in IN cord-015021-pol2qm74 2392 18 the the DT cord-015021-pol2qm74 2392 19 parts part NNS cord-015021-pol2qm74 2392 20 per per IN cord-015021-pol2qm74 2392 21 billion billion CD cord-015021-pol2qm74 2392 22 range range NN cord-015021-pol2qm74 2392 23 [ [ -LRB- cord-015021-pol2qm74 2392 24 3 3 CD cord-015021-pol2qm74 2392 25 ] ] -RRB- cord-015021-pol2qm74 2392 26 , , , cord-015021-pol2qm74 2392 27 which which WDT cord-015021-pol2qm74 2392 28 may may MD cord-015021-pol2qm74 2392 29 reduce reduce VB cord-015021-pol2qm74 2392 30 possible possible JJ cord-015021-pol2qm74 2392 31 toxic toxic JJ cord-015021-pol2qm74 2392 32 side side NN cord-015021-pol2qm74 2392 33 effects effect NNS cord-015021-pol2qm74 2392 34 . . . cord-015021-pol2qm74 2393 1 However however RB cord-015021-pol2qm74 2393 2 , , , cord-015021-pol2qm74 2393 3 in in IN cord-015021-pol2qm74 2393 4 the the DT cord-015021-pol2qm74 2393 5 same same JJ cord-015021-pol2qm74 2393 6 study study NN cord-015021-pol2qm74 2393 7 it -PRON- PRP cord-015021-pol2qm74 2393 8 was be VBD cord-015021-pol2qm74 2393 9 demonstrated demonstrate VBN cord-015021-pol2qm74 2393 10 that that IN cord-015021-pol2qm74 2393 11 the the DT cord-015021-pol2qm74 2393 12 dose dose NN cord-015021-pol2qm74 2393 13 - - HYPH cord-015021-pol2qm74 2393 14 response response NN cord-015021-pol2qm74 2393 15 curves curve NNS cord-015021-pol2qm74 2393 16 for for IN cord-015021-pol2qm74 2393 17 Pa02 Pa02 NNP cord-015021-pol2qm74 2393 18 and and CC cord-015021-pol2qm74 2393 19 PAP pap NN cord-015021-pol2qm74 2393 20 have have VBP cord-015021-pol2qm74 2393 21 different different JJ cord-015021-pol2qm74 2393 22 patterns pattern NNS cord-015021-pol2qm74 2393 23 . . . cord-015021-pol2qm74 2394 1 Whereas whereas IN cord-015021-pol2qm74 2394 2 PAP PAP NNP cord-015021-pol2qm74 2394 3 presented present VBD cord-015021-pol2qm74 2394 4 a a DT cord-015021-pol2qm74 2394 5 continuous continuous JJ cord-015021-pol2qm74 2394 6 dose dose NN cord-015021-pol2qm74 2394 7 - - HYPH cord-015021-pol2qm74 2394 8 dependent dependent JJ cord-015021-pol2qm74 2394 9 downward downward JJ cord-015021-pol2qm74 2394 10 tendency tendency NN cord-015021-pol2qm74 2394 11 with with IN cord-015021-pol2qm74 2394 12 an an DT cord-015021-pol2qm74 2394 13 EDs EDs NNP cord-015021-pol2qm74 2394 14 o o NN cord-015021-pol2qm74 2394 15 of of IN cord-015021-pol2qm74 2394 16 approximately approximately RB cord-015021-pol2qm74 2394 17 2 2 CD cord-015021-pol2qm74 2394 18 - - SYM cord-015021-pol2qm74 2394 19 3 3 CD cord-015021-pol2qm74 2394 20 ppm ppm NN cord-015021-pol2qm74 2394 21 , , , cord-015021-pol2qm74 2394 22 the the DT cord-015021-pol2qm74 2394 23 improvement improvement NN cord-015021-pol2qm74 2394 24 of of IN cord-015021-pol2qm74 2394 25 oxygenation oxygenation NN cord-015021-pol2qm74 2394 26 had have VBD cord-015021-pol2qm74 2394 27 a a DT cord-015021-pol2qm74 2394 28 maximum maximum NN cord-015021-pol2qm74 2394 29 at at IN cord-015021-pol2qm74 2394 30 10 10 CD cord-015021-pol2qm74 2394 31 ppm ppm NN cord-015021-pol2qm74 2394 32 and and CC cord-015021-pol2qm74 2394 33 , , , cord-015021-pol2qm74 2394 34 at at IN cord-015021-pol2qm74 2394 35 higher high JJR cord-015021-pol2qm74 2394 36 doses dose NNS cord-015021-pol2qm74 2394 37 , , , cord-015021-pol2qm74 2394 38 drifted drift VBD cord-015021-pol2qm74 2394 39 back back RB cord-015021-pol2qm74 2394 40 towards towards IN cord-015021-pol2qm74 2394 41 the the DT cord-015021-pol2qm74 2394 42 baseline baseline JJ cord-015021-pol2qm74 2394 43 data datum NNS cord-015021-pol2qm74 2394 44 . . . cord-015021-pol2qm74 2395 1 The the DT cord-015021-pol2qm74 2395 2 ED ED NNP cord-015021-pol2qm74 2395 3 ~ ~ NFP cord-015021-pol2qm74 2395 4 o o NNP cord-015021-pol2qm74 2395 5 was be VBD cord-015021-pol2qm74 2395 6 estimated estimate VBN cord-015021-pol2qm74 2395 7 at at IN cord-015021-pol2qm74 2395 8 approximately approximately RB cord-015021-pol2qm74 2395 9 100 100 CD cord-015021-pol2qm74 2395 10 ppb ppb NN cord-015021-pol2qm74 2395 11 , , , cord-015021-pol2qm74 2395 12 i.e. i.e. FW cord-015021-pol2qm74 2395 13 more more JJR cord-015021-pol2qm74 2395 14 than than IN cord-015021-pol2qm74 2395 15 ten ten CD cord-015021-pol2qm74 2395 16 times time NNS cord-015021-pol2qm74 2395 17 lower low JJR cord-015021-pol2qm74 2395 18 than than IN cord-015021-pol2qm74 2395 19 for for IN cord-015021-pol2qm74 2395 20 the the DT cord-015021-pol2qm74 2395 21 reduction reduction NN cord-015021-pol2qm74 2395 22 of of IN cord-015021-pol2qm74 2395 23 PAP pap NN cord-015021-pol2qm74 2395 24 . . . cord-015021-pol2qm74 2396 1 In in IN cord-015021-pol2qm74 2396 2 conclusion conclusion NN cord-015021-pol2qm74 2396 3 , , , cord-015021-pol2qm74 2396 4 inhalation inhalation NN cord-015021-pol2qm74 2396 5 of of IN cord-015021-pol2qm74 2396 6 NO no NN cord-015021-pol2qm74 2396 7 by by IN cord-015021-pol2qm74 2396 8 patients patient NNS cord-015021-pol2qm74 2396 9 with with IN cord-015021-pol2qm74 2396 10 severe severe JJ cord-015021-pol2qm74 2396 11 ARDS ARDS NNP cord-015021-pol2qm74 2396 12 may may MD cord-015021-pol2qm74 2396 13 result result VB cord-015021-pol2qm74 2396 14 in in IN cord-015021-pol2qm74 2396 15 persistent persistent JJ cord-015021-pol2qm74 2396 16 and and CC cord-015021-pol2qm74 2396 17 reproducible reproducible JJ cord-015021-pol2qm74 2396 18 decreases decrease NNS cord-015021-pol2qm74 2396 19 in in IN cord-015021-pol2qm74 2396 20 PAP pap NN cord-015021-pol2qm74 2396 21 associated associate VBN cord-015021-pol2qm74 2396 22 with with IN cord-015021-pol2qm74 2396 23 an an DT cord-015021-pol2qm74 2396 24 evident evident JJ cord-015021-pol2qm74 2396 25 improvement improvement NN cord-015021-pol2qm74 2396 26 in in IN cord-015021-pol2qm74 2396 27 PAD2 PAD2 NNP cord-015021-pol2qm74 2396 28 , , , cord-015021-pol2qm74 2396 29 thus thus RB cord-015021-pol2qm74 2396 30 allowing allow VBG cord-015021-pol2qm74 2396 31 reduction reduction NN cord-015021-pol2qm74 2396 32 of of IN cord-015021-pol2qm74 2396 33 the the DT cord-015021-pol2qm74 2396 34 F.O F.O NNP cord-015021-pol2qm74 2396 35 2 2 CD cord-015021-pol2qm74 2396 36 . . . cord-015021-pol2qm74 2397 1 NO no DT cord-015021-pol2qm74 2397 2 inhalation inhalation NN cord-015021-pol2qm74 2397 3 should should MD cord-015021-pol2qm74 2397 4 be be VB cord-015021-pol2qm74 2397 5 performed perform VBN cord-015021-pol2qm74 2397 6 using use VBG cord-015021-pol2qm74 2397 7 low low JJ cord-015021-pol2qm74 2397 8 concentrations concentration NNS cord-015021-pol2qm74 2397 9 which which WDT cord-015021-pol2qm74 2397 10 are be VBP cord-015021-pol2qm74 2397 11 less less RBR cord-015021-pol2qm74 2397 12 toxic toxic JJ cord-015021-pol2qm74 2397 13 , , , cord-015021-pol2qm74 2397 14 although although IN cord-015021-pol2qm74 2397 15 any any DT cord-015021-pol2qm74 2397 16 possible possible JJ cord-015021-pol2qm74 2397 17 risks risk NNS cord-015021-pol2qm74 2397 18 still still RB cord-015021-pol2qm74 2397 19 have have VBP cord-015021-pol2qm74 2397 20 to to TO cord-015021-pol2qm74 2397 21 be be VB cord-015021-pol2qm74 2397 22 considered consider VBN cord-015021-pol2qm74 2397 23 carefully carefully RB cord-015021-pol2qm74 2397 24 . . . cord-015021-pol2qm74 2398 1 Dose dose JJ cord-015021-pol2qm74 2398 2 - - HYPH cord-015021-pol2qm74 2398 3 response response NN cord-015021-pol2qm74 2398 4 studies study NNS cord-015021-pol2qm74 2398 5 for for IN cord-015021-pol2qm74 2398 6 the the DT cord-015021-pol2qm74 2398 7 individual individual JJ cord-015021-pol2qm74 2398 8 patients patient NNS cord-015021-pol2qm74 2398 9 are be VBP cord-015021-pol2qm74 2398 10 recommended recommend VBN cord-015021-pol2qm74 2398 11 urgently urgently RB cord-015021-pol2qm74 2398 12 . . . cord-015021-pol2qm74 2399 1 Finally finally RB cord-015021-pol2qm74 2399 2 , , , cord-015021-pol2qm74 2399 3 controlled control VBN cord-015021-pol2qm74 2399 4 randomized randomized JJ cord-015021-pol2qm74 2399 5 studies study NNS cord-015021-pol2qm74 2399 6 are be VBP cord-015021-pol2qm74 2399 7 required require VBN cord-015021-pol2qm74 2399 8 to to TO cord-015021-pol2qm74 2399 9 demonstrate demonstrate VB cord-015021-pol2qm74 2399 10 that that IN cord-015021-pol2qm74 2399 11 additional additional JJ cord-015021-pol2qm74 2399 12 NO no DT cord-015021-pol2qm74 2399 13 inhalation inhalation NN cord-015021-pol2qm74 2399 14 is be VBZ cord-015021-pol2qm74 2399 15 able able JJ cord-015021-pol2qm74 2399 16 to to TO cord-015021-pol2qm74 2399 17 reduce reduce VB cord-015021-pol2qm74 2399 18 mortality mortality NN cord-015021-pol2qm74 2399 19 of of IN cord-015021-pol2qm74 2399 20 ARDS ARDS NNP cord-015021-pol2qm74 2399 21 . . . cord-015021-pol2qm74 2400 1 Inhibition inhibition NN cord-015021-pol2qm74 2400 2 of of IN cord-015021-pol2qm74 2400 3 the the DT cord-015021-pol2qm74 2400 4 activity activity NN cord-015021-pol2qm74 2400 5 of of IN cord-015021-pol2qm74 2400 6 glyceraldehyd-3-phosphate glyceraldehyd-3-phosphate JJ cord-015021-pol2qm74 2400 7 dehydrogenase dehydrogenase NN cord-015021-pol2qm74 2400 8 ( ( -LRB- cord-015021-pol2qm74 2400 9 GAPDH GAPDH NNP cord-015021-pol2qm74 2400 10 ) ) -RRB- cord-015021-pol2qm74 2400 11 , , , cord-015021-pol2qm74 2400 12 an an DT cord-015021-pol2qm74 2400 13 enzyme enzyme NN cord-015021-pol2qm74 2400 14 of of IN cord-015021-pol2qm74 2400 15 the the DT cord-015021-pol2qm74 2400 16 glycolysis glycolysis NN cord-015021-pol2qm74 2400 17 / / SYM cord-015021-pol2qm74 2400 18 gluconeogenetic gluconeogenetic NNP cord-015021-pol2qm74 2400 19 pathway pathway NN cord-015021-pol2qm74 2400 20 , , , cord-015021-pol2qm74 2400 21 through through IN cord-015021-pol2qm74 2400 22 ADP adp NN cord-015021-pol2qm74 2400 23 - - HYPH cord-015021-pol2qm74 2400 24 ribosylation ribosylation NN cord-015021-pol2qm74 2400 25 is be VBZ cord-015021-pol2qm74 2400 26 promoted promote VBN cord-015021-pol2qm74 2400 27 by by IN cord-015021-pol2qm74 2400 28 nitric nitric NN cord-015021-pol2qm74 2400 29 oxide oxide NN cord-015021-pol2qm74 2400 30 ( ( -LRB- cord-015021-pol2qm74 2400 31 NO no RB cord-015021-pol2qm74 2400 32 ) ) -RRB- cord-015021-pol2qm74 2400 33 . . . cord-015021-pol2qm74 2401 1 Since since IN cord-015021-pol2qm74 2401 2 NO no DT cord-015021-pol2qm74 2401 3 is be VBZ cord-015021-pol2qm74 2401 4 produced produce VBN cord-015021-pol2qm74 2401 5 in in IN cord-015021-pol2qm74 2401 6 the the DT cord-015021-pol2qm74 2401 7 septic septic JJ cord-015021-pol2qm74 2401 8 liver liver NN cord-015021-pol2qm74 2401 9 and and CC cord-015021-pol2qm74 2401 10 hypoglycemia hypoglycemia NN cord-015021-pol2qm74 2401 11 is be VBZ cord-015021-pol2qm74 2401 12 a a DT cord-015021-pol2qm74 2401 13 major major JJ cord-015021-pol2qm74 2401 14 problem problem NN cord-015021-pol2qm74 2401 15 of of IN cord-015021-pol2qm74 2401 16 late late JJ cord-015021-pol2qm74 2401 17 sepsis sepsis NN cord-015021-pol2qm74 2401 18 , , , cord-015021-pol2qm74 2401 19 it -PRON- PRP cord-015021-pol2qm74 2401 20 was be VBD cord-015021-pol2qm74 2401 21 investigated investigate VBN cord-015021-pol2qm74 2401 22 whether whether IN cord-015021-pol2qm74 2401 23 NO no DT cord-015021-pol2qm74 2401 24 interferes interfere VBZ cord-015021-pol2qm74 2401 25 with with IN cord-015021-pol2qm74 2401 26 gluconeogenesis gluconeogenesis NN cord-015021-pol2qm74 2401 27 of of IN cord-015021-pol2qm74 2401 28 hepatocytes hepatocyte NNS cord-015021-pol2qm74 2401 29 . . . cord-015021-pol2qm74 2402 1 Hepatocytes Hepatocytes NNP cord-015021-pol2qm74 2402 2 ( ( -LRB- cord-015021-pol2qm74 2402 3 HC HC NNP cord-015021-pol2qm74 2402 4 ) ) -RRB- cord-015021-pol2qm74 2402 5 were be VBD cord-015021-pol2qm74 2402 6 isolated isolate VBN cord-015021-pol2qm74 2402 7 from from IN cord-015021-pol2qm74 2402 8 Sprague Sprague NNP cord-015021-pol2qm74 2402 9 - - HYPH cord-015021-pol2qm74 2402 10 Dawley Dawley NNP cord-015021-pol2qm74 2402 11 rats rat NNS cord-015021-pol2qm74 2402 12 using use VBG cord-015021-pol2qm74 2402 13 a a DT cord-015021-pol2qm74 2402 14 collagenase collagenase NN cord-015021-pol2qm74 2402 15 perfusion perfusion NN cord-015021-pol2qm74 2402 16 technique technique NN cord-015021-pol2qm74 2402 17 and and CC cord-015021-pol2qm74 2402 18 differential differential JJ cord-015021-pol2qm74 2402 19 centrifugation centrifugation NN cord-015021-pol2qm74 2402 20 . . . cord-015021-pol2qm74 2403 1 Exogenous exogenous JJ cord-015021-pol2qm74 2403 2 NO NO NNP cord-015021-pol2qm74 2403 3 was be VBD cord-015021-pol2qm74 2403 4 applied apply VBN cord-015021-pol2qm74 2403 5 by by IN cord-015021-pol2qm74 2403 6 incubation incubation NN cord-015021-pol2qm74 2403 7 with with IN cord-015021-pol2qm74 2403 8 the the DT cord-015021-pol2qm74 2403 9 NO NO NNP cord-015021-pol2qm74 2403 10 - - HYPH cord-015021-pol2qm74 2403 11 donors donor NNS cord-015021-pol2qm74 2403 12 S s NN cord-015021-pol2qm74 2403 13 - - HYPH cord-015021-pol2qm74 2403 14 nitrosyl nitrosyl NNP cord-015021-pol2qm74 2403 15 - - HYPH cord-015021-pol2qm74 2403 16 acetylpenicillamine acetylpenicillamine NN cord-015021-pol2qm74 2403 17 and and CC cord-015021-pol2qm74 2403 18 sodium sodium NN cord-015021-pol2qm74 2403 19 - - HYPH cord-015021-pol2qm74 2403 20 nitroprusside nitroprusside RB cord-015021-pol2qm74 2403 21 . . . cord-015021-pol2qm74 2404 1 Endogenous endogenous JJ cord-015021-pol2qm74 2404 2 NO no DT cord-015021-pol2qm74 2404 3 synthesis synthesis NN cord-015021-pol2qm74 2404 4 was be VBD cord-015021-pol2qm74 2404 5 induced induce VBN cord-015021-pol2qm74 2404 6 by by IN cord-015021-pol2qm74 2404 7 incubation incubation NN cord-015021-pol2qm74 2404 8 with with IN cord-015021-pol2qm74 2404 9 cytokines cytokine NNS cord-015021-pol2qm74 2404 10 ( ( -LRB- cord-015021-pol2qm74 2404 11 TNFcq TNFcq NNP cord-015021-pol2qm74 2404 12 IL-1 IL-1 NNP cord-015021-pol2qm74 2404 13 , , , cord-015021-pol2qm74 2404 14 IFNJ IFNJ NNP cord-015021-pol2qm74 2404 15 and and CC cord-015021-pol2qm74 2404 16 lipopolysacchafide lipopolysacchafide NNP cord-015021-pol2qm74 2404 17 ( ( -LRB- cord-015021-pol2qm74 2404 18 LPS LPS NNP cord-015021-pol2qm74 2404 19 ) ) -RRB- cord-015021-pol2qm74 2404 20 . . . cord-015021-pol2qm74 2405 1 24 24 CD cord-015021-pol2qm74 2405 2 hrs hrs NN cord-015021-pol2qm74 2405 3 later later RB cord-015021-pol2qm74 2405 4 the the DT cord-015021-pol2qm74 2405 5 incubation incubation NN cord-015021-pol2qm74 2405 6 medium medium NN cord-015021-pol2qm74 2405 7 was be VBD cord-015021-pol2qm74 2405 8 changed change VBN cord-015021-pol2qm74 2405 9 to to IN cord-015021-pol2qm74 2405 10 a a DT cord-015021-pol2qm74 2405 11 solution solution NN cord-015021-pol2qm74 2405 12 containing contain VBG cord-015021-pol2qm74 2405 13 lactate lactate NN cord-015021-pol2qm74 2405 14 , , , cord-015021-pol2qm74 2405 15 ornithine ornithine NN cord-015021-pol2qm74 2405 16 , , , cord-015021-pol2qm74 2405 17 lysine lysine NN cord-015021-pol2qm74 2405 18 , , , cord-015021-pol2qm74 2405 19 ammoniumchloride ammoniumchloride NN cord-015021-pol2qm74 2405 20 and and CC cord-015021-pol2qm74 2405 21 glucagon glucagon NN cord-015021-pol2qm74 2405 22 for for IN cord-015021-pol2qm74 2405 23 optimal optimal JJ cord-015021-pol2qm74 2405 24 conditions condition NNS cord-015021-pol2qm74 2405 25 of of IN cord-015021-pol2qm74 2405 26 gluconeogenesis gluconeogenesis NN cord-015021-pol2qm74 2405 27 . . . cord-015021-pol2qm74 2406 1 After after IN cord-015021-pol2qm74 2406 2 3 3 CD cord-015021-pol2qm74 2406 3 more more JJR cord-015021-pol2qm74 2406 4 hrs hrs NN cord-015021-pol2qm74 2406 5 glucose glucose NN cord-015021-pol2qm74 2406 6 and and CC cord-015021-pol2qm74 2406 7 nitrite nitrite NN cord-015021-pol2qm74 2406 8 levels level NNS cord-015021-pol2qm74 2406 9 were be VBD cord-015021-pol2qm74 2406 10 determined determine VBN cord-015021-pol2qm74 2406 11 spectrophotometrically spectrophotometrically RB cord-015021-pol2qm74 2406 12 . . . cord-015021-pol2qm74 2407 1 GAPDH GAPDH NNP cord-015021-pol2qm74 2407 2 activity activity NN cord-015021-pol2qm74 2407 3 was be VBD cord-015021-pol2qm74 2407 4 measured measure VBN cord-015021-pol2qm74 2407 5 by by IN cord-015021-pol2qm74 2407 6 the the DT cord-015021-pol2qm74 2407 7 NADH NADH NNP cord-015021-pol2qm74 2407 8 - - HYPH cord-015021-pol2qm74 2407 9 dependent dependent JJ cord-015021-pol2qm74 2407 10 conversion conversion NN cord-015021-pol2qm74 2407 11 of of IN cord-015021-pol2qm74 2407 12 1,3-diphosphoglycerate 1,3-diphosphoglycerate CD cord-015021-pol2qm74 2407 13 to to IN cord-015021-pol2qm74 2407 14 glyceraldehyde-3-phosphate glyceraldehyde-3-phosphate NNP cord-015021-pol2qm74 2407 15 . . . cord-015021-pol2qm74 2408 1 Incubation Incubation NNP cord-015021-pol2qm74 2408 2 of of IN cord-015021-pol2qm74 2408 3 HC HC NNP cord-015021-pol2qm74 2408 4 with with IN cord-015021-pol2qm74 2408 5 NO no DT cord-015021-pol2qm74 2408 6 - - HYPH cord-015021-pol2qm74 2408 7 donors donor NNS cord-015021-pol2qm74 2408 8 led lead VBD cord-015021-pol2qm74 2408 9 to to IN cord-015021-pol2qm74 2408 10 a a DT cord-015021-pol2qm74 2408 11 concentrationdependent concentrationdependent NN cord-015021-pol2qm74 2408 12 inhibition inhibition NN cord-015021-pol2qm74 2408 13 of of IN cord-015021-pol2qm74 2408 14 gluconeogenesis gluconeogenesis NN cord-015021-pol2qm74 2408 15 and and CC cord-015021-pol2qm74 2408 16 GAPDH GAPDH NNP cord-015021-pol2qm74 2408 17 activity activity NN cord-015021-pol2qm74 2408 18 . . . cord-015021-pol2qm74 2409 1 However however RB cord-015021-pol2qm74 2409 2 , , , cord-015021-pol2qm74 2409 3 GAPDH GAPDH NNP cord-015021-pol2qm74 2409 4 activity activity NN cord-015021-pol2qm74 2409 5 was be VBD cord-015021-pol2qm74 2409 6 about about RB cord-015021-pol2qm74 2409 7 5 5 CD cord-015021-pol2qm74 2409 8 times time NNS cord-015021-pol2qm74 2409 9 more more RBR cord-015021-pol2qm74 2409 10 sensitive sensitive JJ cord-015021-pol2qm74 2409 11 to to IN cord-015021-pol2qm74 2409 12 the the DT cord-015021-pol2qm74 2409 13 inhibitory inhibitory JJ cord-015021-pol2qm74 2409 14 effect effect NN cord-015021-pol2qm74 2409 15 of of IN cord-015021-pol2qm74 2409 16 exogenous exogenous JJ cord-015021-pol2qm74 2409 17 NO no NN cord-015021-pol2qm74 2409 18 . . . cord-015021-pol2qm74 2409 19 incubation incubation NN cord-015021-pol2qm74 2409 20 of of IN cord-015021-pol2qm74 2409 21 HC HC NNP cord-015021-pol2qm74 2409 22 with with IN cord-015021-pol2qm74 2409 23 cytokines cytokine NNS cord-015021-pol2qm74 2409 24 and and CC cord-015021-pol2qm74 2409 25 LPS LPS NNP cord-015021-pol2qm74 2409 26 induced induce VBD cord-015021-pol2qm74 2409 27 NQ NQ NNP cord-015021-pol2qm74 2409 28 synthesis synthesis NN cord-015021-pol2qm74 2409 29 as as IN cord-015021-pol2qm74 2409 30 measured measure VBN cord-015021-pol2qm74 2409 31 by by IN cord-015021-pol2qm74 2409 32 an an DT cord-015021-pol2qm74 2409 33 increase increase NN cord-015021-pol2qm74 2409 34 in in IN cord-015021-pol2qm74 2409 35 nitrite nitrite NN cord-015021-pol2qm74 2409 36 concentrations concentration NNS cord-015021-pol2qm74 2409 37 . . . cord-015021-pol2qm74 2410 1 Endogenously Endogenously NNP cord-015021-pol2qm74 2410 2 produced produce VBD cord-015021-pol2qm74 2410 3 NO no DT cord-015021-pol2qm74 2410 4 suppressed suppress VBN cord-015021-pol2qm74 2410 5 gluconeogenesis gluconeogenesis NN cord-015021-pol2qm74 2410 6 by by IN cord-015021-pol2qm74 2410 7 49_+3 49_+3 CD cord-015021-pol2qm74 2410 8 % % NN cord-015021-pol2qm74 2410 9 . . . cord-015021-pol2qm74 2411 1 In in IN cord-015021-pol2qm74 2411 2 contrast contrast NN cord-015021-pol2qm74 2411 3 to to IN cord-015021-pol2qm74 2411 4 exogenously exogenously RB cord-015021-pol2qm74 2411 5 applied apply VBN cord-015021-pol2qm74 2411 6 NO no RB cord-015021-pol2qm74 2411 7 , , , cord-015021-pol2qm74 2411 8 the the DT cord-015021-pol2qm74 2411 9 effect effect NN cord-015021-pol2qm74 2411 10 of of IN cord-015021-pol2qm74 2411 11 endogenous endogenous JJ cord-015021-pol2qm74 2411 12 NO no DT cord-015021-pol2qm74 2411 13 synthesis synthesis NN cord-015021-pol2qm74 2411 14 was be VBD cord-015021-pol2qm74 2411 15 less less JJR cord-015021-pol2qm74 2411 16 on on IN cord-015021-pol2qm74 2411 17 GAPDH GAPDH NNP cord-015021-pol2qm74 2411 18 activity activity NN cord-015021-pol2qm74 2411 19 resulting result VBG cord-015021-pol2qm74 2411 20 in in IN cord-015021-pol2qm74 2411 21 an an DT cord-015021-pol2qm74 2411 22 inhibition inhibition NN cord-015021-pol2qm74 2411 23 of of IN cord-015021-pol2qm74 2411 24 only only RB cord-015021-pol2qm74 2411 25 32_+12 32_+12 CD cord-015021-pol2qm74 2411 26 % % NN cord-015021-pol2qm74 2411 27 . . . cord-015021-pol2qm74 2412 1 In in IN cord-015021-pol2qm74 2412 2 conclusion conclusion NN cord-015021-pol2qm74 2412 3 , , , cord-015021-pol2qm74 2412 4 exogenous exogenous JJ cord-015021-pol2qm74 2412 5 and and CC cord-015021-pol2qm74 2412 6 endogenous endogenous JJ cord-015021-pol2qm74 2412 7 NO no DT cord-015021-pol2qm74 2412 8 inhibited inhibited JJ cord-015021-pol2qm74 2412 9 gluconeogenesis gluconeogenesis NN cord-015021-pol2qm74 2412 10 as as RB cord-015021-pol2qm74 2412 11 well well RB cord-015021-pol2qm74 2412 12 as as IN cord-015021-pol2qm74 2412 13 GAPDH GAPDH NNP cord-015021-pol2qm74 2412 14 activity activity NN cord-015021-pol2qm74 2412 15 . . . cord-015021-pol2qm74 2413 1 However however RB cord-015021-pol2qm74 2413 2 , , , cord-015021-pol2qm74 2413 3 there there EX cord-015021-pol2qm74 2413 4 was be VBD cord-015021-pol2qm74 2413 5 no no DT cord-015021-pol2qm74 2413 6 correlation correlation NN cord-015021-pol2qm74 2413 7 between between IN cord-015021-pol2qm74 2413 8 the the DT cord-015021-pol2qm74 2413 9 extent extent NN cord-015021-pol2qm74 2413 10 of of IN cord-015021-pol2qm74 2413 11 inhibition inhibition NN cord-015021-pol2qm74 2413 12 of of IN cord-015021-pol2qm74 2413 13 these these DT cord-015021-pol2qm74 2413 14 two two CD cord-015021-pol2qm74 2413 15 parameters parameter NNS cord-015021-pol2qm74 2413 16 of of IN cord-015021-pol2qm74 2413 17 hepatocellular hepatocellular JJ cord-015021-pol2qm74 2413 18 glucose glucose NN cord-015021-pol2qm74 2413 19 metabolism metabolism NN cord-015021-pol2qm74 2413 20 . . . cord-015021-pol2qm74 2414 1 We -PRON- PRP cord-015021-pol2qm74 2414 2 have have VBP cord-015021-pol2qm74 2414 3 shown show VBN cord-015021-pol2qm74 2414 4 that that DT cord-015021-pol2qm74 2414 5 inhibition inhibition NN cord-015021-pol2qm74 2414 6 of of IN cord-015021-pol2qm74 2414 7 hepatocyte hepatocyte NN cord-015021-pol2qm74 2414 8 ( ( -LRB- cord-015021-pol2qm74 2414 9 HEP HEP NNP cord-015021-pol2qm74 2414 10 ) ) -RRB- cord-015021-pol2qm74 2414 11 synthesis synthesis NN cord-015021-pol2qm74 2414 12 of of IN cord-015021-pol2qm74 2414 13 nitric nitric NN cord-015021-pol2qm74 2414 14 oxide oxide NN cord-015021-pol2qm74 2414 15 ( ( -LRB- cord-015021-pol2qm74 2414 16 NO no UH cord-015021-pol2qm74 2414 17 ) ) -RRB- cord-015021-pol2qm74 2414 18 potentiates potentiate VBZ cord-015021-pol2qm74 2414 19 cell cell NN cord-015021-pol2qm74 2414 20 injury injury NN cord-015021-pol2qm74 2414 21 in in IN cord-015021-pol2qm74 2414 22 a a DT cord-015021-pol2qm74 2414 23 model model NN cord-015021-pol2qm74 2414 24 of of IN cord-015021-pol2qm74 2414 25 acetaminopheninduced acetaminopheninduced JJ cord-015021-pol2qm74 2414 26 oxidative oxidative JJ cord-015021-pol2qm74 2414 27 stress stress NN cord-015021-pol2qm74 2414 28 and and CC cord-015021-pol2qm74 2414 29 the the DT cord-015021-pol2qm74 2414 30 extent extent NN cord-015021-pol2qm74 2414 31 of of IN cord-015021-pol2qm74 2414 32 damage damage NN cord-015021-pol2qm74 2414 33 was be VBD cord-015021-pol2qm74 2414 34 paralleled parallel VBN cord-015021-pol2qm74 2414 35 by by IN cord-015021-pol2qm74 2414 36 depletion depletion NN cord-015021-pol2qm74 2414 37 of of IN cord-015021-pol2qm74 2414 38 reduced reduce VBN cord-015021-pol2qm74 2414 39 glutathione glutathione NN cord-015021-pol2qm74 2414 40 ( ( -LRB- cord-015021-pol2qm74 2414 41 GSH GSH NNP cord-015021-pol2qm74 2414 42 ) ) -RRB- cord-015021-pol2qm74 2414 43 stores store NNS cord-015021-pol2qm74 2414 44 . . . cord-015021-pol2qm74 2415 1 To to TO cord-015021-pol2qm74 2415 2 clarify clarify VB cord-015021-pol2qm74 2415 3 the the DT cord-015021-pol2qm74 2415 4 role role NN cord-015021-pol2qm74 2415 5 of of IN cord-015021-pol2qm74 2415 6 NO no DT cord-015021-pol2qm74 2415 7 in in IN cord-015021-pol2qm74 2415 8 modulating modulate VBG cord-015021-pol2qm74 2415 9 the the DT cord-015021-pol2qm74 2415 10 redox redox JJ cord-015021-pol2qm74 2415 11 state state NN cord-015021-pol2qm74 2415 12 of of IN cord-015021-pol2qm74 2415 13 HEP HEP NNP cord-015021-pol2qm74 2415 14 , , , cord-015021-pol2qm74 2415 15 we -PRON- PRP cord-015021-pol2qm74 2415 16 studied study VBD cord-015021-pol2qm74 2415 17 the the DT cord-015021-pol2qm74 2415 18 effect effect NN cord-015021-pol2qm74 2415 19 of of IN cord-015021-pol2qm74 2415 20 inhibition inhibition NN cord-015021-pol2qm74 2415 21 of of IN cord-015021-pol2qm74 2415 22 cytokine cytokine NN cord-015021-pol2qm74 2415 23 - - HYPH cord-015021-pol2qm74 2415 24 mediated mediate VBN cord-015021-pol2qm74 2415 25 NO no DT cord-015021-pol2qm74 2415 26 production production NN cord-015021-pol2qm74 2415 27 on on IN cord-015021-pol2qm74 2415 28 HEP HEP NNP cord-015021-pol2qm74 2415 29 GSH GSH NNP cord-015021-pol2qm74 2415 30 stores store NNS cord-015021-pol2qm74 2415 31 , , , cord-015021-pol2qm74 2415 32 in in IN cord-015021-pol2qm74 2415 33 a a DT cord-015021-pol2qm74 2415 34 system system NN cord-015021-pol2qm74 2415 35 of of IN cord-015021-pol2qm74 2415 36 isolated isolate VBN cord-015021-pol2qm74 2415 37 rat rat NN cord-015021-pol2qm74 2415 38 HEP hep NN cord-015021-pol2qm74 2415 39 in in IN cord-015021-pol2qm74 2415 40 primary primary JJ cord-015021-pol2qm74 2415 41 culture culture NN cord-015021-pol2qm74 2415 42 , , , cord-015021-pol2qm74 2415 43 NO no DT cord-015021-pol2qm74 2415 44 synthesis synthesis NN cord-015021-pol2qm74 2415 45 was be VBD cord-015021-pol2qm74 2415 46 induced induce VBN cord-015021-pol2qm74 2415 47 ( ( -LRB- cord-015021-pol2qm74 2415 48 STIM STIM NNP cord-015021-pol2qm74 2415 49 ) ) -RRB- cord-015021-pol2qm74 2415 50 by by IN cord-015021-pol2qm74 2415 51 exposure exposure NN cord-015021-pol2qm74 2415 52 to to IN cord-015021-pol2qm74 2415 53 IL-1 IL-1 NNP cord-015021-pol2qm74 2415 54 , , , cord-015021-pol2qm74 2415 55 TNF TNF NNP cord-015021-pol2qm74 2415 56 , , , cord-015021-pol2qm74 2415 57 IFN IFN NNP cord-015021-pol2qm74 2415 58 , , , cord-015021-pol2qm74 2415 59 and and CC cord-015021-pol2qm74 2415 60 LPS LPS NNP cord-015021-pol2qm74 2415 61 for for IN cord-015021-pol2qm74 2415 62 16 16 CD cord-015021-pol2qm74 2415 63 hours hour NNS cord-015021-pol2qm74 2415 64 . . . cord-015021-pol2qm74 2416 1 20 20 CD cord-015021-pol2qm74 2416 2 , , , cord-015021-pol2qm74 2416 3 60 60 CD cord-015021-pol2qm74 2416 4 , , , cord-015021-pol2qm74 2416 5 120 120 CD cord-015021-pol2qm74 2416 6 and and CC cord-015021-pol2qm74 2416 7 200 200 CD cord-015021-pol2qm74 2416 8 ~M ~M NFP cord-015021-pol2qm74 2416 9 of of IN cord-015021-pol2qm74 2416 10 N n CD cord-015021-pol2qm74 2416 11 - - HYPH cord-015021-pol2qm74 2416 12 monomethyI monomethyI NNP cord-015021-pol2qm74 2416 13 - - HYPH cord-015021-pol2qm74 2416 14 L l NN cord-015021-pol2qm74 2416 15 - - HYPH cord-015021-pol2qm74 2416 16 arginine arginine NN cord-015021-pol2qm74 2416 17 ( ( -LRB- cord-015021-pol2qm74 2416 18 NMMA NMMA NNP cord-015021-pol2qm74 2416 19 ) ) -RRB- cord-015021-pol2qm74 2416 20 , , , cord-015021-pol2qm74 2416 21 a a DT cord-015021-pol2qm74 2416 22 specific specific JJ cord-015021-pol2qm74 2416 23 inhibitor inhibitor NN cord-015021-pol2qm74 2416 24 of of IN cord-015021-pol2qm74 2416 25 NO no DT cord-015021-pol2qm74 2416 26 synthesis synthesis NN cord-015021-pol2qm74 2416 27 , , , cord-015021-pol2qm74 2416 28 was be VBD cord-015021-pol2qm74 2416 29 added add VBN cord-015021-pol2qm74 2416 30 . . . cord-015021-pol2qm74 2417 1 Cells cell NNS cord-015021-pol2qm74 2417 2 incubated incubate VBN cord-015021-pol2qm74 2417 3 in in IN cord-015021-pol2qm74 2417 4 media medium NNS cord-015021-pol2qm74 2417 5 alone alone RB cord-015021-pol2qm74 2417 6 served serve VBD cord-015021-pol2qm74 2417 7 as as IN cord-015021-pol2qm74 2417 8 controls control NNS cord-015021-pol2qm74 2417 9 ( ( -LRB- cord-015021-pol2qm74 2417 10 CONT CONT NNP cord-015021-pol2qm74 2417 11 ) ) -RRB- cord-015021-pol2qm74 2417 12 . . . cord-015021-pol2qm74 2418 1 The the DT cord-015021-pol2qm74 2418 2 NO no DT cord-015021-pol2qm74 2418 3 metabolite metabolite NN cord-015021-pol2qm74 2418 4 ( ( -LRB- cord-015021-pol2qm74 2418 5 NO2 NO2 NNP cord-015021-pol2qm74 2418 6 ) ) -RRB- cord-015021-pol2qm74 2418 7 ; ; : cord-015021-pol2qm74 2418 8 aspartate aspartate NNP cord-015021-pol2qm74 2418 9 aminotransferase aminotransferase NN cord-015021-pol2qm74 2418 10 ( ( -LRB- cord-015021-pol2qm74 2418 11 AST AST NNP cord-015021-pol2qm74 2418 12 ) ) -RRB- cord-015021-pol2qm74 2418 13 , , , cord-015021-pol2qm74 2418 14 an an DT cord-015021-pol2qm74 2418 15 indicator indicator NN cord-015021-pol2qm74 2418 16 of of IN cord-015021-pol2qm74 2418 17 cell cell NN cord-015021-pol2qm74 2418 18 injury injury NN cord-015021-pol2qm74 2418 19 ; ; , cord-015021-pol2qm74 2418 20 and and CC cord-015021-pol2qm74 2418 21 GSH GSH NNP cord-015021-pol2qm74 2418 22 were be VBD cord-015021-pol2qm74 2418 23 assayed assay VBN cord-015021-pol2qm74 2418 24 . . . cord-015021-pol2qm74 2419 1 ( ( -LRB- cord-015021-pol2qm74 2419 2 Data datum NNS cord-015021-pol2qm74 2419 3 presented present VBN cord-015021-pol2qm74 2419 4 as as IN cord-015021-pol2qm74 2419 5 mean mean JJ cord-015021-pol2qm74 2419 6 + + CC cord-015021-pol2qm74 2419 7 SEM sem NN cord-015021-pol2qm74 2419 8 ; ; , cord-015021-pol2qm74 2419 9 n=4 n=4 JJ cord-015021-pol2qm74 2419 10 . . . cord-015021-pol2qm74 2419 11 ) ) -RRB- cord-015021-pol2qm74 2420 1 GSH GSH NNP cord-015021-pol2qm74 2420 2 ( ( -LRB- cord-015021-pol2qm74 2420 3 nmoVma nmoVma NNP cord-015021-pol2qm74 2420 4 orotein orotein NNP cord-015021-pol2qm74 2420 5 ) ) -RRB- cord-015021-pol2qm74 2420 6 .. .. . cord-015021-pol2qm74 2421 1 ~ ~ NFP cord-015021-pol2qm74 2421 2 ( ( -LRB- cord-015021-pol2qm74 2421 3 nmol nmol NNP cord-015021-pol2qm74 2421 4 / / SYM cord-015021-pol2qm74 2421 5 ma ma NNP cord-015021-pol2qm74 2421 6 orotein orotein NNP cord-015021-pol2qm74 2421 7 ) ) -RRB- cord-015021-pol2qm74 2421 8 CONT CONT NNP cord-015021-pol2qm74 2421 9 14.1 14.1 CD cord-015021-pol2qm74 2421 10 + + SYM cord-015021-pol2qm74 2421 11 0.3 0.3 CD cord-015021-pol2qm74 2421 12 32 32 CD cord-015021-pol2qm74 2421 13 + + SYM cord-015021-pol2qm74 2421 14 4.0 4.0 CD cord-015021-pol2qm74 2421 15 # # NN cord-015021-pol2qm74 2421 16 STIM STIM NNP cord-015021-pol2qm74 2421 17 13.4 13.4 CD cord-015021-pol2qm74 2421 18 + + SYM cord-015021-pol2qm74 2421 19 0.6 0.6 CD cord-015021-pol2qm74 2421 20 139 139 CD cord-015021-pol2qm74 2421 21 + + CD cord-015021-pol2qm74 2422 1 12 12 CD cord-015021-pol2qm74 2422 2 STIM+2O STIM+2O NNS cord-015021-pol2qm74 2422 3 tzM tzM NNP cord-015021-pol2qm74 2422 4 NMMA NMMA NNP cord-015021-pol2qm74 2422 5 12.7 12.7 CD cord-015021-pol2qm74 2422 6 + + SYM cord-015021-pol2qm74 2422 7 1.1 1.1 CD cord-015021-pol2qm74 2422 8 88 88 CD cord-015021-pol2qm74 2422 9 + + SYM cord-015021-pol2qm74 2422 10 5.0 5.0 CD cord-015021-pol2qm74 2422 11 # # NN cord-015021-pol2qm74 2422 12 STIM+60 stim+60 NN cord-015021-pol2qm74 2423 1 ~M ~M NFP cord-015021-pol2qm74 2423 2 NMMA NMMA NNP cord-015021-pol2qm74 2423 3 9.9 9.9 CD cord-015021-pol2qm74 2423 4 _ _ NNP cord-015021-pol2qm74 2423 5 .. .. . cord-015021-pol2qm74 2424 1 + + CC cord-015021-pol2qm74 2424 2 0.4 0.4 CD cord-015021-pol2qm74 2424 3 * * NFP cord-015021-pol2qm74 2424 4 68 68 CD cord-015021-pol2qm74 2424 5 + + SYM cord-015021-pol2qm74 2424 6 4.5 4.5 CD cord-015021-pol2qm74 2424 7 # # NN cord-015021-pol2qm74 2424 8 STIM+120 stim+120 CD cord-015021-pol2qm74 2424 9 pM pm NN cord-015021-pol2qm74 2424 10 NMMA NMMA NNP cord-015021-pol2qm74 2424 11 7.6 7.6 CD cord-015021-pol2qm74 2424 12 + + SYM cord-015021-pol2qm74 2424 13 0.6 0.6 CD cord-015021-pol2qm74 2424 14 * * NFP cord-015021-pol2qm74 2424 15 57 57 CD cord-015021-pol2qm74 2424 16 + + SYM cord-015021-pol2qm74 2424 17 3.0 3.0 CD cord-015021-pol2qm74 2424 18 # # NN cord-015021-pol2qm74 2424 19 STIM+200 stim+200 CD cord-015021-pol2qm74 2424 20 ) ) -RRB- cord-015021-pol2qm74 2425 1 lM lM NNP cord-015021-pol2qm74 2426 1 NMMA NMMA NNP cord-015021-pol2qm74 2426 2 5.0 5.0 CD cord-015021-pol2qm74 2426 3 + + SYM cord-015021-pol2qm74 2426 4 0.5 0.5 CD cord-015021-pol2qm74 2427 1 * * NFP cord-015021-pol2qm74 2427 2 37 37 CD cord-015021-pol2qm74 2427 3 + + SYM cord-015021-pol2qm74 2427 4 2.5 2.5 CD cord-015021-pol2qm74 2427 5 # # NN cord-015021-pol2qm74 2427 6 ANOVA ANOVA NNP cord-015021-pol2qm74 2428 1 0,0002 0,0002 $ cord-015021-pol2qm74 2428 2 0.0001 0.0001 CD cord-015021-pol2qm74 2429 1 ( ( -LRB- cord-015021-pol2qm74 2429 2 * * NFP cord-015021-pol2qm74 2429 3 p p XX cord-015021-pol2qm74 2429 4 < < XX cord-015021-pol2qm74 2429 5 0.05 0.05 CD cord-015021-pol2qm74 2429 6 versus versus IN cord-015021-pol2qm74 2429 7 STIM STIM NNP cord-015021-pol2qm74 2429 8 , , , cord-015021-pol2qm74 2429 9 # # NN cord-015021-pol2qm74 2429 10 p p NN cord-015021-pol2qm74 2429 11 < < XX cord-015021-pol2qm74 2429 12 0.01 0.01 CD cord-015021-pol2qm74 2429 13 versus versus IN cord-015021-pol2qm74 2429 14 STIM STIM NNP cord-015021-pol2qm74 2429 15 ; ; : cord-015021-pol2qm74 2429 16 ANOVA ANOVA NNP cord-015021-pol2qm74 2429 17 with with IN cord-015021-pol2qm74 2429 18 Neuman Neuman NNP cord-015021-pol2qm74 2429 19 - - HYPH cord-015021-pol2qm74 2429 20 Keuls Keuls NNP cord-015021-pol2qm74 2429 21 ) ) -RRB- cord-015021-pol2qm74 2429 22 GSH GSH NNP cord-015021-pol2qm74 2429 23 in in IN cord-015021-pol2qm74 2429 24 CONT+120 CONT+120 NNP cord-015021-pol2qm74 2430 1 I -PRON- PRP cord-015021-pol2qm74 2431 1 ~M ~M NFP cord-015021-pol2qm74 2431 2 L L NNP cord-015021-pol2qm74 2431 3 - - HYPH cord-015021-pol2qm74 2431 4 NMMA NMMA NNP cord-015021-pol2qm74 2431 5 was be VBD cord-015021-pol2qm74 2431 6 equivalent equivalent JJ cord-015021-pol2qm74 2431 7 to to IN cord-015021-pol2qm74 2431 8 that that DT cord-015021-pol2qm74 2431 9 of of IN cord-015021-pol2qm74 2431 10 CONT CONT NNP cord-015021-pol2qm74 2431 11 ( ( -LRB- cord-015021-pol2qm74 2431 12 13.3 13.3 CD cord-015021-pol2qm74 2431 13 vs.14.1 vs.14.1 NNP cord-015021-pol2qm74 2431 14 ) ) -RRB- cord-015021-pol2qm74 2431 15 . . . cord-015021-pol2qm74 2432 1 AST AST NNP cord-015021-pol2qm74 2432 2 release release NN cord-015021-pol2qm74 2432 3 was be VBD cord-015021-pol2qm74 2432 4 equivalent equivalent JJ cord-015021-pol2qm74 2432 5 in in IN cord-015021-pol2qm74 2432 6 all all DT cord-015021-pol2qm74 2432 7 treatment treatment NN cord-015021-pol2qm74 2432 8 groups group NNS cord-015021-pol2qm74 2432 9 . . . cord-015021-pol2qm74 2433 1 These these DT cord-015021-pol2qm74 2433 2 data datum NNS cord-015021-pol2qm74 2433 3 show show VBP cord-015021-pol2qm74 2433 4 that that IN cord-015021-pol2qm74 2433 5 inhibition inhibition NN cord-015021-pol2qm74 2433 6 of of IN cord-015021-pol2qm74 2433 7 HEP HEP NNP cord-015021-pol2qm74 2433 8 synthesis synthesis NN cord-015021-pol2qm74 2433 9 of of IN cord-015021-pol2qm74 2433 10 NO no DT cord-015021-pol2qm74 2433 11 depletes deplete VBZ cord-015021-pol2qm74 2433 12 intracellular intracellular JJ cord-015021-pol2qm74 2433 13 stores store NNS cord-015021-pol2qm74 2433 14 of of IN cord-015021-pol2qm74 2433 15 reduced reduce VBN cord-015021-pol2qm74 2433 16 GSH GSH NNP cord-015021-pol2qm74 2433 17 . . . cord-015021-pol2qm74 2434 1 We -PRON- PRP cord-015021-pol2qm74 2434 2 conclude conclude VBP cord-015021-pol2qm74 2434 3 that that IN cord-015021-pol2qm74 2434 4 hepatocyte hepatocyte NN cord-015021-pol2qm74 2434 5 NO no DT cord-015021-pol2qm74 2434 6 production production NN cord-015021-pol2qm74 2434 7 modulates modulate VBZ cord-015021-pol2qm74 2434 8 cellular cellular JJ cord-015021-pol2qm74 2434 9 GSH GSH NNP cord-015021-pol2qm74 2434 10 homeostasis homeostasis NN cord-015021-pol2qm74 2434 11 and and CC cord-015021-pol2qm74 2434 12 as as IN cord-015021-pol2qm74 2434 13 a a DT cord-015021-pol2qm74 2434 14 result result NN cord-015021-pol2qm74 2434 15 , , , cord-015021-pol2qm74 2434 16 may may MD cord-015021-pol2qm74 2434 17 be be VB cord-015021-pol2qm74 2434 18 hepatoprotective hepatoprotective JJ cord-015021-pol2qm74 2434 19 in in IN cord-015021-pol2qm74 2434 20 oxidative oxidative JJ cord-015021-pol2qm74 2434 21 injury injury NN cord-015021-pol2qm74 2434 22 . . . cord-015021-pol2qm74 2434 23 _SP cord-015021-pol2qm74 2435 1 Nitric nitric NN cord-015021-pol2qm74 2435 2 oxide oxide NN cord-015021-pol2qm74 2435 3 ( ( -LRB- cord-015021-pol2qm74 2435 4 NO no UH cord-015021-pol2qm74 2435 5 ) ) -RRB- cord-015021-pol2qm74 2435 6 is be VBZ cord-015021-pol2qm74 2435 7 a a DT cord-015021-pol2qm74 2435 8 modulator modulator NN cord-015021-pol2qm74 2435 9 of of IN cord-015021-pol2qm74 2435 10 immune immune JJ cord-015021-pol2qm74 2435 11 response response NN cord-015021-pol2qm74 2435 12 and and CC cord-015021-pol2qm74 2435 13 may may MD cord-015021-pol2qm74 2435 14 be be VB cord-015021-pol2qm74 2435 15 involved involve VBN cord-015021-pol2qm74 2435 16 in in IN cord-015021-pol2qm74 2435 17 thE the DT cord-015021-pol2qm74 2435 18 changes change NNS cord-015021-pol2qm74 2435 19 in in IN cord-015021-pol2qm74 2435 20 immune immune JJ cord-015021-pol2qm74 2435 21 reactivity reactivity NN cord-015021-pol2qm74 2435 22 after after IN cord-015021-pol2qm74 2435 23 major major JJ cord-015021-pol2qm74 2435 24 trauma trauma NN cord-015021-pol2qm74 2435 25 and and CC cord-015021-pol2qm74 2435 26 operations operation NNS cord-015021-pol2qm74 2435 27 . . . cord-015021-pol2qm74 2436 1 We -PRON- PRP cord-015021-pol2qm74 2436 2 investigated investigate VBD cord-015021-pol2qm74 2436 3 NO no JJ cord-015021-pol2qm74 2436 4 - - HYPH cord-015021-pol2qm74 2436 5 generation generation NN cord-015021-pol2qm74 2436 6 in in IN cord-015021-pol2qm74 2436 7 rat rat NN cord-015021-pol2qm74 2436 8 and and CC cord-015021-pol2qm74 2436 9 mice mice NN cord-015021-pol2qm74 2436 10 spleen spleen NN cord-015021-pol2qm74 2436 11 cells cell NNS cord-015021-pol2qm74 2436 12 ( ( -LRB- cord-015021-pol2qm74 2436 13 SC SC NNP cord-015021-pol2qm74 2436 14 ) ) -RRB- cord-015021-pol2qm74 2436 15 after after IN cord-015021-pol2qm74 2436 16 partial partial JJ cord-015021-pol2qm74 2436 17 hepatectomy hepatectomy NN cord-015021-pol2qm74 2436 18 ( ( -LRB- cord-015021-pol2qm74 2436 19 PH PH NNP cord-015021-pol2qm74 2436 20 ) ) -RRB- cord-015021-pol2qm74 2436 21 . . . cord-015021-pol2qm74 2437 1 C57BL/6 C57BL/6 NNP cord-015021-pol2qm74 2437 2 mice mouse NNS cord-015021-pol2qm74 2437 3 and and CC cord-015021-pol2qm74 2437 4 LEW LEW NNP cord-015021-pol2qm74 2437 5 rats rat NNS cord-015021-pol2qm74 2437 6 underwent undergo VBD cord-015021-pol2qm74 2437 7 a a DT cord-015021-pol2qm74 2437 8 50 50 CD cord-015021-pol2qm74 2437 9 % % NN cord-015021-pol2qm74 2437 10 and and CC cord-015021-pol2qm74 2437 11 70 70 CD cord-015021-pol2qm74 2437 12 % % NN cord-015021-pol2qm74 2437 13 PH ph NN cord-015021-pol2qm74 2437 14 , , , cord-015021-pol2qm74 2437 15 respectively respectively RB cord-015021-pol2qm74 2437 16 . . . cord-015021-pol2qm74 2438 1 SC SC NNP cord-015021-pol2qm74 2438 2 were be VBD cord-015021-pol2qm74 2438 3 prepared prepared JJ cord-015021-pol2qm74 2438 4 1 1 CD cord-015021-pol2qm74 2438 5 - - SYM cord-015021-pol2qm74 2438 6 6 6 CD cord-015021-pol2qm74 2438 7 days day NNS cord-015021-pol2qm74 2438 8 after after IN cord-015021-pol2qm74 2438 9 PH PH NNP cord-015021-pol2qm74 2438 10 and and CC cord-015021-pol2qm74 2438 11 plated plate VBD cord-015021-pol2qm74 2438 12 at at IN cord-015021-pol2qm74 2438 13 1 1 CD cord-015021-pol2qm74 2438 14 to to IN cord-015021-pol2qm74 2438 15 2 2 CD cord-015021-pol2qm74 2438 16 x x SYM cord-015021-pol2qm74 2438 17 10ecells 10ecells CD cord-015021-pol2qm74 2438 18 per per IN cord-015021-pol2qm74 2438 19 well well RB cord-015021-pol2qm74 2438 20 . . . cord-015021-pol2qm74 2439 1 After after IN cord-015021-pol2qm74 2439 2 20 20 CD cord-015021-pol2qm74 2439 3 h h NN cord-015021-pol2qm74 2439 4 incubation incubation NN cord-015021-pol2qm74 2439 5 at at IN cord-015021-pol2qm74 2439 6 37 37 CD cord-015021-pol2qm74 2439 7 ° ° NN cord-015021-pol2qm74 2439 8 C c NN cord-015021-pol2qm74 2439 9 , , , cord-015021-pol2qm74 2439 10 NO no JJ cord-015021-pol2qm74 2439 11 - - HYPH cord-015021-pol2qm74 2439 12 production production NN cord-015021-pol2qm74 2439 13 was be VBD cord-015021-pol2qm74 2439 14 measured measure VBN cord-015021-pol2qm74 2439 15 as as IN cord-015021-pol2qm74 2439 16 nitrite nitrite NN cord-015021-pol2qm74 2439 17 levels level NNS cord-015021-pol2qm74 2439 18 ( ( -LRB- cord-015021-pol2qm74 2439 19 Griess Griess NNP cord-015021-pol2qm74 2439 20 reagent reagent NN cord-015021-pol2qm74 2439 21 ) ) -RRB- cord-015021-pol2qm74 2439 22 . . . cord-015021-pol2qm74 2440 1 Normal normal JJ cord-015021-pol2qm74 2440 2 mouse mouse NN cord-015021-pol2qm74 2440 3 SC SC NNP cord-015021-pol2qm74 2440 4 did do VBD cord-015021-pol2qm74 2440 5 not not RB cord-015021-pol2qm74 2440 6 produce produce VB cord-015021-pol2qm74 2440 7 NO no NN cord-015021-pol2qm74 2440 8 , , , cord-015021-pol2qm74 2440 9 neither neither CC cord-015021-pol2qm74 2440 10 basal basal NN cord-015021-pol2qm74 2440 11 nor nor CC cord-015021-pol2qm74 2440 12 in in IN cord-015021-pol2qm74 2440 13 response response NN cord-015021-pol2qm74 2440 14 to to IN cord-015021-pol2qm74 2440 15 LPS LPS NNP cord-015021-pol2qm74 2440 16 or or CC cord-015021-pol2qm74 2440 17 Con Con NNP cord-015021-pol2qm74 2440 18 A a NN cord-015021-pol2qm74 2441 1 Starting start VBG cord-015021-pol2qm74 2441 2 at at IN cord-015021-pol2qm74 2441 3 the the DT cord-015021-pol2qm74 2441 4 second second JJ cord-015021-pol2qm74 2441 5 day day NN cord-015021-pol2qm74 2441 6 after after IN cord-015021-pol2qm74 2441 7 PH PH NNP cord-015021-pol2qm74 2441 8 , , , cord-015021-pol2qm74 2441 9 we -PRON- PRP cord-015021-pol2qm74 2441 10 found find VBD cord-015021-pol2qm74 2441 11 a a DT cord-015021-pol2qm74 2441 12 substantial substantial JJ cord-015021-pol2qm74 2441 13 production production NN cord-015021-pol2qm74 2441 14 of of IN cord-015021-pol2qm74 2441 15 NO no NN cord-015021-pol2qm74 2441 16 . . . cord-015021-pol2qm74 2442 1 In in IN cord-015021-pol2qm74 2442 2 rats rat NNS cord-015021-pol2qm74 2442 3 , , , cord-015021-pol2qm74 2442 4 also also RB cord-015021-pol2qm74 2442 5 SC SC NNP cord-015021-pol2qm74 2442 6 from from IN cord-015021-pol2qm74 2442 7 control control NN cord-015021-pol2qm74 2442 8 animals animal NNS cord-015021-pol2qm74 2442 9 were be VBD cord-015021-pol2qm74 2442 10 able able JJ cord-015021-pol2qm74 2442 11 to to TO cord-015021-pol2qm74 2442 12 generate generate VB cord-015021-pol2qm74 2442 13 NO no DT cord-015021-pol2qm74 2442 14 ; ; : cord-015021-pol2qm74 2442 15 both both DT cord-015021-pol2qm74 2442 16 basal basal NN cord-015021-pol2qm74 2442 17 and and CC cord-015021-pol2qm74 2442 18 stimulated stimulate VBD cord-015021-pol2qm74 2442 19 NO no JJ cord-015021-pol2qm74 2442 20 - - HYPH cord-015021-pol2qm74 2442 21 generation generation NN cord-015021-pol2qm74 2442 22 were be VBD cord-015021-pol2qm74 2442 23 further further RB cord-015021-pol2qm74 2442 24 enhanced enhance VBN cord-015021-pol2qm74 2442 25 after after IN cord-015021-pol2qm74 2442 26 PH PH NNP cord-015021-pol2qm74 2442 27 ( ( -LRB- cord-015021-pol2qm74 2442 28 Table table NN cord-015021-pol2qm74 2442 29 , , , cord-015021-pol2qm74 2442 30 values value NNS cord-015021-pol2qm74 2442 31 expressed express VBN cord-015021-pol2qm74 2442 32 as as IN cord-015021-pol2qm74 2442 33 mean mean JJ cord-015021-pol2qm74 2442 34 --SE --SE NNP cord-015021-pol2qm74 2442 35 ) ) -RRB- cord-015021-pol2qm74 2442 36 . . . cord-015021-pol2qm74 2443 1 After after IN cord-015021-pol2qm74 2443 2 shame shame NN cord-015021-pol2qm74 2443 3 operation operation NN cord-015021-pol2qm74 2443 4 , , , cord-015021-pol2qm74 2443 5 there there EX cord-015021-pol2qm74 2443 6 was be VBD cord-015021-pol2qm74 2443 7 only only RB cord-015021-pol2qm74 2443 8 a a DT cord-015021-pol2qm74 2443 9 modest modest JJ cord-015021-pol2qm74 2443 10 elevation elevation NN cord-015021-pol2qm74 2443 11 of of IN cord-015021-pol2qm74 2443 12 NOproduction NOproduction NNP cord-015021-pol2qm74 2443 13 in in IN cord-015021-pol2qm74 2443 14 rat rat NN cord-015021-pol2qm74 2443 15 and and CC cord-015021-pol2qm74 2443 16 mouse mouse NN cord-015021-pol2qm74 2443 17 SC SC NNP cord-015021-pol2qm74 2443 18 . . . cord-015021-pol2qm74 2444 1 In in IN cord-015021-pol2qm74 2444 2 first first JJ cord-015021-pol2qm74 2444 3 experiments experiment NNS cord-015021-pol2qm74 2444 4 we -PRON- PRP cord-015021-pol2qm74 2444 5 could could MD cord-015021-pol2qm74 2444 6 demonstrate demonstrate VB cord-015021-pol2qm74 2444 7 NO NO NNP cord-015021-pol2qm74 2444 8 - - HYPH cord-015021-pol2qm74 2444 9 production production NN cord-015021-pol2qm74 2444 10 also also RB cord-015021-pol2qm74 2444 11 in in IN cord-015021-pol2qm74 2444 12 phagocytes phagocyte NNS cord-015021-pol2qm74 2444 13 from from IN cord-015021-pol2qm74 2444 14 a a DT cord-015021-pol2qm74 2444 15 patient patient JJ cord-015021-pol2qm74 2444 16 3 3 CD cord-015021-pol2qm74 2444 17 days day NNS cord-015021-pol2qm74 2444 18 aider aider NN cord-015021-pol2qm74 2444 19 liver liver NN cord-015021-pol2qm74 2444 20 partial partial JJ cord-015021-pol2qm74 2444 21 resection resection NN cord-015021-pol2qm74 2444 22 ( ( -LRB- cord-015021-pol2qm74 2444 23 1.4 1.4 CD cord-015021-pol2qm74 2444 24 nmol nmol JJ cord-015021-pol2qm74 2444 25 nitrite/106 nitrite/106 NNP cord-015021-pol2qm74 2444 26 cells cell NNS cord-015021-pol2qm74 2444 27 ) ) -RRB- cord-015021-pol2qm74 2445 1 Enhanced enhanced JJ cord-015021-pol2qm74 2445 2 NO no JJ cord-015021-pol2qm74 2445 3 - - HYPH cord-015021-pol2qm74 2445 4 production production NN cord-015021-pol2qm74 2445 5 in in IN cord-015021-pol2qm74 2445 6 macrophages macrophage NNS cord-015021-pol2qm74 2445 7 may may MD cord-015021-pol2qm74 2445 8 contribute contribute VB cord-015021-pol2qm74 2445 9 to to IN cord-015021-pol2qm74 2445 10 the the DT cord-015021-pol2qm74 2445 11 changes change NNS cord-015021-pol2qm74 2445 12 of of IN cord-015021-pol2qm74 2445 13 immune immune JJ cord-015021-pol2qm74 2445 14 reactivity reactivity NN cord-015021-pol2qm74 2445 15 after after IN cord-015021-pol2qm74 2445 16 partial partial JJ cord-015021-pol2qm74 2445 17 hepatectomy hepatectomy NN cord-015021-pol2qm74 2445 18 . . . cord-015021-pol2qm74 2446 1 Nitric nitric NN cord-015021-pol2qm74 2446 2 oxide oxide NN cord-015021-pol2qm74 2446 3 ( ( -LRB- cord-015021-pol2qm74 2446 4 NO no UH cord-015021-pol2qm74 2446 5 ) ) -RRB- cord-015021-pol2qm74 2446 6 is be VBZ cord-015021-pol2qm74 2446 7 recognized recognize VBN cord-015021-pol2qm74 2446 8 as as IN cord-015021-pol2qm74 2446 9 an an DT cord-015021-pol2qm74 2446 10 important important JJ cord-015021-pol2qm74 2446 11 mediator mediator NN cord-015021-pol2qm74 2446 12 in in IN cord-015021-pol2qm74 2446 13 endotoxemia endotoxemia NN cord-015021-pol2qm74 2446 14 and and CC cord-015021-pol2qm74 2446 15 sepsis sepsis NN cord-015021-pol2qm74 2446 16 . . . cord-015021-pol2qm74 2447 1 Increased increase VBN cord-015021-pol2qm74 2447 2 synthesis synthesis NN cord-015021-pol2qm74 2447 3 of of IN cord-015021-pol2qm74 2447 4 NO no DT cord-015021-pol2qm74 2447 5 has have VBZ cord-015021-pol2qm74 2447 6 been be VBN cord-015021-pol2qm74 2447 7 demonstrated demonstrate VBN cord-015021-pol2qm74 2447 8 in in IN cord-015021-pol2qm74 2447 9 septic septic JJ cord-015021-pol2qm74 2447 10 humans human NNS cord-015021-pol2qm74 2447 11 and and CC cord-015021-pol2qm74 2447 12 animals animal NNS cord-015021-pol2qm74 2447 13 , , , cord-015021-pol2qm74 2447 14 and and CC cord-015021-pol2qm74 2447 15 NO no DT cord-015021-pol2qm74 2447 16 inhibitors inhibitor NNS cord-015021-pol2qm74 2447 17 have have VBP cord-015021-pol2qm74 2447 18 been be VBN cord-015021-pol2qm74 2447 19 used use VBN cord-015021-pol2qm74 2447 20 in in IN cord-015021-pol2qm74 2447 21 the the DT cord-015021-pol2qm74 2447 22 treatment treatment NN cord-015021-pol2qm74 2447 23 of of IN cord-015021-pol2qm74 2447 24 septic septic JJ cord-015021-pol2qm74 2447 25 shock shock NN cord-015021-pol2qm74 2447 26 . . . cord-015021-pol2qm74 2448 1 Recent recent JJ cord-015021-pol2qm74 2448 2 reports report NNS cord-015021-pol2qm74 2448 3 have have VBP cord-015021-pol2qm74 2448 4 , , , cord-015021-pol2qm74 2448 5 however however RB cord-015021-pol2qm74 2448 6 , , , cord-015021-pol2qm74 2448 7 suggested suggest VBD cord-015021-pol2qm74 2448 8 that that IN cord-015021-pol2qm74 2448 9 this this DT cord-015021-pol2qm74 2448 10 form form NN cord-015021-pol2qm74 2448 11 of of IN cord-015021-pol2qm74 2448 12 therapy therapy NN cord-015021-pol2qm74 2448 13 may may MD cord-015021-pol2qm74 2448 14 cause cause VB cord-015021-pol2qm74 2448 15 serious serious JJ cord-015021-pol2qm74 2448 16 organ organ NN cord-015021-pol2qm74 2448 17 damage damage NN cord-015021-pol2qm74 2448 18 . . . cord-015021-pol2qm74 2449 1 In in IN cord-015021-pol2qm74 2449 2 the the DT cord-015021-pol2qm74 2449 3 present present JJ cord-015021-pol2qm74 2449 4 investigation investigation NN cord-015021-pol2qm74 2449 5 circulatory circulatory JJ cord-015021-pol2qm74 2449 6 and and CC cord-015021-pol2qm74 2449 7 metabolic metabolic JJ cord-015021-pol2qm74 2449 8 changes change NNS cord-015021-pol2qm74 2449 9 in in IN cord-015021-pol2qm74 2449 10 the the DT cord-015021-pol2qm74 2449 11 liver liver NN cord-015021-pol2qm74 2449 12 were be VBD cord-015021-pol2qm74 2449 13 studied study VBN cord-015021-pol2qm74 2449 14 during during IN cord-015021-pol2qm74 2449 15 treatment treatment NN cord-015021-pol2qm74 2449 16 with with IN cord-015021-pol2qm74 2449 17 the the DT cord-015021-pol2qm74 2449 18 NO no JJ cord-015021-pol2qm74 2449 19 - - HYPH cord-015021-pol2qm74 2449 20 synthase synthase NN cord-015021-pol2qm74 2449 21 inhibitor inhibitor NN cord-015021-pol2qm74 2449 22 N N NNP cord-015021-pol2qm74 2449 23 - - HYPH cord-015021-pol2qm74 2449 24 nitro nitro NNP cord-015021-pol2qm74 2449 25 - - HYPH cord-015021-pol2qm74 2449 26 L l NN cord-015021-pol2qm74 2449 27 - - HYPH cord-015021-pol2qm74 2449 28 arginine arginine NN cord-015021-pol2qm74 2449 29 - - HYPH cord-015021-pol2qm74 2449 30 methyl methyl NN cord-015021-pol2qm74 2449 31 ester ester NN cord-015021-pol2qm74 2449 32 ( ( -LRB- cord-015021-pol2qm74 2449 33 L l NN cord-015021-pol2qm74 2449 34 - - HYPH cord-015021-pol2qm74 2449 35 NAME NAME NNP cord-015021-pol2qm74 2449 36 ) ) -RRB- cord-015021-pol2qm74 2449 37 in in IN cord-015021-pol2qm74 2449 38 endotoxemia endotoxemia NN cord-015021-pol2qm74 2449 39 . . . cord-015021-pol2qm74 2450 1 Methods method NNS cord-015021-pol2qm74 2450 2 : : : cord-015021-pol2qm74 2450 3 Juvenile juvenile JJ cord-015021-pol2qm74 2450 4 pigs pig NNS cord-015021-pol2qm74 2450 5 were be VBD cord-015021-pol2qm74 2450 6 randomized randomize VBN cord-015021-pol2qm74 2450 7 to to IN cord-015021-pol2qm74 2450 8 one one CD cord-015021-pol2qm74 2450 9 of of IN cord-015021-pol2qm74 2450 10 the the DT cord-015021-pol2qm74 2450 11 following following JJ cord-015021-pol2qm74 2450 12 treatment treatment NN cord-015021-pol2qm74 2450 13 groups group NNS cord-015021-pol2qm74 2450 14 : : : cord-015021-pol2qm74 2450 15 1 1 LS cord-015021-pol2qm74 2450 16 ) ) -RRB- cord-015021-pol2qm74 2451 1 Encletoxin Encletoxin NNP cord-015021-pol2qm74 2451 2 and and CC cord-015021-pol2qm74 2451 3 L L NNP cord-015021-pol2qm74 2451 4 - - HYPH cord-015021-pol2qm74 2451 5 NAME NAME NNP cord-015021-pol2qm74 2451 6 , , , cord-015021-pol2qm74 2451 7 2 2 CD cord-015021-pol2qm74 2451 8 ) ) -RRB- cord-015021-pol2qm74 2451 9 Endotoxin endotoxin NN cord-015021-pol2qm74 2451 10 , , , cord-015021-pol2qm74 2451 11 3 3 CD cord-015021-pol2qm74 2451 12 ) ) -RRB- cord-015021-pol2qm74 2451 13 NaCI NaCI NNP cord-015021-pol2qm74 2451 14 and and CC cord-015021-pol2qm74 2451 15 L L NNP cord-015021-pol2qm74 2451 16 - - HYPH cord-015021-pol2qm74 2451 17 NAME NAME NNP cord-015021-pol2qm74 2451 18 , , , cord-015021-pol2qm74 2451 19 4 4 CD cord-015021-pol2qm74 2451 20 ) ) -RRB- cord-015021-pol2qm74 2451 21 NaCh nach NN cord-015021-pol2qm74 2451 22 Preliminary preliminary JJ cord-015021-pol2qm74 2451 23 results result NNS cord-015021-pol2qm74 2451 24 from from IN cord-015021-pol2qm74 2451 25 groups group NNS cord-015021-pol2qm74 2451 26 1 1 CD cord-015021-pol2qm74 2451 27 ( ( -LRB- cord-015021-pol2qm74 2451 28 n=7 n=7 NNS cord-015021-pol2qm74 2451 29 ) ) -RRB- cord-015021-pol2qm74 2451 30 and and CC cord-015021-pol2qm74 2451 31 2 2 LS cord-015021-pol2qm74 2451 32 ( ( -LRB- cord-015021-pol2qm74 2451 33 n=8 n=8 NN cord-015021-pol2qm74 2451 34 ) ) -RRB- cord-015021-pol2qm74 2451 35 are be VBP cord-015021-pol2qm74 2451 36 presented present VBN cord-015021-pol2qm74 2451 37 . . . cord-015021-pol2qm74 2452 1 Catheters catheter NNS cord-015021-pol2qm74 2452 2 for for IN cord-015021-pol2qm74 2452 3 pressure pressure NN cord-015021-pol2qm74 2452 4 measurement measurement NN cord-015021-pol2qm74 2452 5 were be VBD cord-015021-pol2qm74 2452 6 introduced introduce VBN cord-015021-pol2qm74 2452 7 into into IN cord-015021-pol2qm74 2452 8 the the DT cord-015021-pol2qm74 2452 9 aorta aorta NN cord-015021-pol2qm74 2452 10 , , , cord-015021-pol2qm74 2452 11 hepatic hepatic JJ cord-015021-pol2qm74 2452 12 and and CC cord-015021-pol2qm74 2452 13 portal portal JJ cord-015021-pol2qm74 2452 14 veins vein NNS cord-015021-pol2qm74 2452 15 and and CC cord-015021-pol2qm74 2452 16 ultrasonic ultrasonic JJ cord-015021-pol2qm74 2452 17 transit transit NN cord-015021-pol2qm74 2452 18 time time NN cord-015021-pol2qm74 2452 19 flow flow NN cord-015021-pol2qm74 2452 20 probes probe NNS cord-015021-pol2qm74 2452 21 were be VBD cord-015021-pol2qm74 2452 22 placed place VBN cord-015021-pol2qm74 2452 23 on on IN cord-015021-pol2qm74 2452 24 the the DT cord-015021-pol2qm74 2452 25 hepatic hepatic JJ cord-015021-pol2qm74 2452 26 artery artery NN cord-015021-pol2qm74 2452 27 and and CC cord-015021-pol2qm74 2452 28 portal portal JJ cord-015021-pol2qm74 2452 29 vein vein NN cord-015021-pol2qm74 2452 30 . . . cord-015021-pol2qm74 2453 1 A a DT cord-015021-pol2qm74 2453 2 catheter catheter NN cord-015021-pol2qm74 2453 3 was be VBD cord-015021-pol2qm74 2453 4 introduced introduce VBN cord-015021-pol2qm74 2453 5 into into IN cord-015021-pol2qm74 2453 6 the the DT cord-015021-pol2qm74 2453 7 pulmonary pulmonary JJ cord-015021-pol2qm74 2453 8 artery artery NN cord-015021-pol2qm74 2453 9 . . . cord-015021-pol2qm74 2454 1 Endotoxin Endotoxin NNP cord-015021-pol2qm74 2454 2 ( ( -LRB- cord-015021-pol2qm74 2454 3 1.7 1.7 CD cord-015021-pol2qm74 2454 4 gg gg NNP cord-015021-pol2qm74 2454 5 / / SYM cord-015021-pol2qm74 2454 6 kg kg NNP cord-015021-pol2qm74 2454 7 / / SYM cord-015021-pol2qm74 2454 8 h h NN cord-015021-pol2qm74 2454 9 ) ) -RRB- cord-015021-pol2qm74 2454 10 was be VBD cord-015021-pol2qm74 2454 11 given give VBN cord-015021-pol2qm74 2454 12 as as IN cord-015021-pol2qm74 2454 13 a a DT cord-015021-pol2qm74 2454 14 continous continous JJ cord-015021-pol2qm74 2454 15 portal portal JJ cord-015021-pol2qm74 2454 16 infusion infusion NN cord-015021-pol2qm74 2454 17 over over IN cord-015021-pol2qm74 2454 18 the the DT cord-015021-pol2qm74 2454 19 entire entire JJ cord-015021-pol2qm74 2454 20 observation observation NN cord-015021-pol2qm74 2454 21 period period NN cord-015021-pol2qm74 2454 22 of of IN cord-015021-pol2qm74 2454 23 8 8 CD cord-015021-pol2qm74 2454 24 hrs hrs NN cord-015021-pol2qm74 2454 25 . . . cord-015021-pol2qm74 2455 1 L l NN cord-015021-pol2qm74 2455 2 - - HYPH cord-015021-pol2qm74 2455 3 NAME NAME NNP cord-015021-pol2qm74 2455 4 ( ( -LRB- cord-015021-pol2qm74 2455 5 25 25 CD cord-015021-pol2qm74 2455 6 mg mg NNP cord-015021-pol2qm74 2455 7 / / SYM cord-015021-pol2qm74 2455 8 kg kg NNP cord-015021-pol2qm74 2455 9 ) ) -RRB- cord-015021-pol2qm74 2455 10 was be VBD cord-015021-pol2qm74 2455 11 given give VBN cord-015021-pol2qm74 2455 12 as as IN cord-015021-pol2qm74 2455 13 a a DT cord-015021-pol2qm74 2455 14 bolus bolus NN cord-015021-pol2qm74 2455 15 after after IN cord-015021-pol2qm74 2455 16 3 3 CD cord-015021-pol2qm74 2455 17 hrs hrs NN cord-015021-pol2qm74 2455 18 . . . cord-015021-pol2qm74 2456 1 of of IN cord-015021-pol2qm74 2456 2 endotoxemia endotoxemia NN cord-015021-pol2qm74 2456 3 . . . cord-015021-pol2qm74 2457 1 Results result NNS cord-015021-pol2qm74 2457 2 : : : cord-015021-pol2qm74 2458 1 Endotoxin endotoxin NN cord-015021-pol2qm74 2458 2 transiently transiently RB cord-015021-pol2qm74 2458 3 reduced reduce VBD cord-015021-pol2qm74 2458 4 portal portal JJ cord-015021-pol2qm74 2458 5 vein vein NN cord-015021-pol2qm74 2458 6 flow flow NN cord-015021-pol2qm74 2458 7 ( ( -LRB- cord-015021-pol2qm74 2458 8 PVF PVF NNP cord-015021-pol2qm74 2458 9 ) ) -RRB- cord-015021-pol2qm74 2458 10 by by IN cord-015021-pol2qm74 2458 11 25 25 CD cord-015021-pol2qm74 2458 12 % % NN cord-015021-pol2qm74 2458 13 * * NFP cord-015021-pol2qm74 2458 14 and and CC cord-015021-pol2qm74 2458 15 hepatic hepatic JJ cord-015021-pol2qm74 2458 16 artery artery NN cord-015021-pol2qm74 2458 17 flow flow NN cord-015021-pol2qm74 2458 18 ( ( -LRB- cord-015021-pol2qm74 2458 19 HAl hal JJ cord-015021-pol2qm74 2458 20 e e NN cord-015021-pol2qm74 2458 21 ) ) -RRB- cord-015021-pol2qm74 2458 22 by by IN cord-015021-pol2qm74 2458 23 45 45 CD cord-015021-pol2qm74 2458 24 % % NN cord-015021-pol2qm74 2459 1 * * NFP cord-015021-pol2qm74 2459 2 , , , cord-015021-pol2qm74 2459 3 while while IN cord-015021-pol2qm74 2459 4 L l NN cord-015021-pol2qm74 2459 5 - - HYPH cord-015021-pol2qm74 2459 6 NAME NAME NNP cord-015021-pol2qm74 2459 7 caused cause VBD cord-015021-pol2qm74 2459 8 a a DT cord-015021-pol2qm74 2459 9 further further JJ cord-015021-pol2qm74 2459 10 and and CC cord-015021-pol2qm74 2459 11 lasting lasting JJ cord-015021-pol2qm74 2459 12 reduction reduction NN cord-015021-pol2qm74 2459 13 in in IN cord-015021-pol2qm74 2459 14 flow flow NN cord-015021-pol2qm74 2459 15 ( ( -LRB- cord-015021-pol2qm74 2459 16 PVF PVF NNP cord-015021-pol2qm74 2459 17 78 78 CD cord-015021-pol2qm74 2459 18 % % NN cord-015021-pol2qm74 2459 19 , , , cord-015021-pol2qm74 2459 20 HAF HAF NNP cord-015021-pol2qm74 2459 21 90 90 CD cord-015021-pol2qm74 2459 22 % % NN cord-015021-pol2qm74 2459 23 ) ) -RRB- cord-015021-pol2qm74 2460 1 * * NFP cord-015021-pol2qm74 2460 2 . . . cord-015021-pol2qm74 2461 1 Transhepatic Transhepatic NNP cord-015021-pol2qm74 2461 2 ( ( -LRB- cord-015021-pol2qm74 2461 3 portal portal JJ cord-015021-pol2qm74 2461 4 - - HYPH cord-015021-pol2qm74 2461 5 hepatic hepatic JJ cord-015021-pol2qm74 2461 6 vein vein NN cord-015021-pol2qm74 2461 7 ) ) -RRB- cord-015021-pol2qm74 2462 1 vascular vascular JJ cord-015021-pol2qm74 2462 2 resistance resistance NN cord-015021-pol2qm74 2462 3 increased increase VBD cord-015021-pol2qm74 2462 4 to to IN cord-015021-pol2qm74 2462 5 3 3 CD cord-015021-pol2qm74 2462 6 times time NNS cord-015021-pol2qm74 2462 7 baseline baseline JJ cord-015021-pol2qm74 2462 8 value value NN cord-015021-pol2qm74 2462 9 during during IN cord-015021-pol2qm74 2462 10 endotoxemia endotoxemia NN cord-015021-pol2qm74 2462 11 while while IN cord-015021-pol2qm74 2462 12 L l NN cord-015021-pol2qm74 2462 13 - - HYPH cord-015021-pol2qm74 2462 14 NAME NAME NNP cord-015021-pol2qm74 2462 15 caused cause VBD cord-015021-pol2qm74 2462 16 a a DT cord-015021-pol2qm74 2462 17 further further RB cord-015021-pol2qm74 2462 18 marked mark VBN cord-015021-pol2qm74 2462 19 increase increase NN cord-015021-pol2qm74 2462 20 in in IN cord-015021-pol2qm74 2462 21 resistance resistance NN cord-015021-pol2qm74 2462 22 to to IN cord-015021-pol2qm74 2462 23 12 12 CD cord-015021-pol2qm74 2462 24 times time NNS cord-015021-pol2qm74 2462 25 initial initial JJ cord-015021-pol2qm74 2462 26 value value NN cord-015021-pol2qm74 2462 27 . . . cord-015021-pol2qm74 2463 1 Portal portal JJ cord-015021-pol2qm74 2463 2 oxygen oxygen NN cord-015021-pol2qm74 2463 3 saturation saturation NN cord-015021-pol2qm74 2463 4 ( ( -LRB- cord-015021-pol2qm74 2463 5 SO2 SO2 NNP cord-015021-pol2qm74 2463 6 ) ) -RRB- cord-015021-pol2qm74 2463 7 decreased decrease VBD cord-015021-pol2qm74 2463 8 by by IN cord-015021-pol2qm74 2463 9 60 60 CD cord-015021-pol2qm74 2463 10 % % NN cord-015021-pol2qm74 2463 11 * * NFP cord-015021-pol2qm74 2463 12 during during IN cord-015021-pol2qm74 2463 13 endotoxemia endotoxemia NN cord-015021-pol2qm74 2463 14 . . . cord-015021-pol2qm74 2464 1 L l NN cord-015021-pol2qm74 2464 2 - - HYPH cord-015021-pol2qm74 2464 3 NAME name NN cord-015021-pol2qm74 2464 4 caused cause VBD cord-015021-pol2qm74 2464 5 a a DT cord-015021-pol2qm74 2464 6 reduction reduction NN cord-015021-pol2qm74 2464 7 in in IN cord-015021-pol2qm74 2464 8 portal portal JJ cord-015021-pol2qm74 2464 9 SO2 SO2 NNP cord-015021-pol2qm74 2464 10 by by IN cord-015021-pol2qm74 2464 11 87 87 CD cord-015021-pol2qm74 2464 12 % % NN cord-015021-pol2qm74 2465 1 * * NFP cord-015021-pol2qm74 2465 2 . . . cord-015021-pol2qm74 2466 1 Arterial arterial JJ cord-015021-pol2qm74 2466 2 SO2 SO2 NNP cord-015021-pol2qm74 2466 3 was be VBD cord-015021-pol2qm74 2466 4 unchanged unchanged JJ cord-015021-pol2qm74 2466 5 in in IN cord-015021-pol2qm74 2466 6 both both DT cord-015021-pol2qm74 2466 7 groups group NNS cord-015021-pol2qm74 2466 8 . . . cord-015021-pol2qm74 2467 1 Hepatic hepatic JJ cord-015021-pol2qm74 2467 2 oxygen oxygen NN cord-015021-pol2qm74 2467 3 uptake uptake NN cord-015021-pol2qm74 2467 4 was be VBD cord-015021-pol2qm74 2467 5 not not RB cord-015021-pol2qm74 2467 6 changed change VBN cord-015021-pol2qm74 2467 7 by by IN cord-015021-pol2qm74 2467 8 endotoxin endotoxin NN cord-015021-pol2qm74 2467 9 , , , cord-015021-pol2qm74 2467 10 but but CC cord-015021-pol2qm74 2467 11 was be VBD cord-015021-pol2qm74 2467 12 markedly markedly RB cord-015021-pol2qm74 2467 13 reduced reduce VBN cord-015021-pol2qm74 2467 14 after after IN cord-015021-pol2qm74 2467 15 addition addition NN cord-015021-pol2qm74 2467 16 of of IN cord-015021-pol2qm74 2467 17 L l NN cord-015021-pol2qm74 2467 18 - - HYPH cord-015021-pol2qm74 2467 19 NAME NAME NNP cord-015021-pol2qm74 2467 20 . . . cord-015021-pol2qm74 2468 1 Endotoxin endotoxin NN cord-015021-pol2qm74 2468 2 caused cause VBD cord-015021-pol2qm74 2468 3 a a DT cord-015021-pol2qm74 2468 4 27 27 CD cord-015021-pol2qm74 2468 5 % % NN cord-015021-pol2qm74 2468 6 reduction reduction NN cord-015021-pol2qm74 2468 7 in in IN cord-015021-pol2qm74 2468 8 cardiac cardiac JJ cord-015021-pol2qm74 2468 9 output output NN cord-015021-pol2qm74 2468 10 ( ( -LRB- cord-015021-pol2qm74 2468 11 CO CO NNP cord-015021-pol2qm74 2468 12 ) ) -RRB- cord-015021-pol2qm74 2468 13 . . . cord-015021-pol2qm74 2469 1 The the DT cord-015021-pol2qm74 2469 2 addition addition NN cord-015021-pol2qm74 2469 3 of of IN cord-015021-pol2qm74 2469 4 L l NN cord-015021-pol2qm74 2469 5 - - HYPH cord-015021-pol2qm74 2469 6 NAME NAME NNP cord-015021-pol2qm74 2469 7 reduced reduce VBN cord-015021-pol2qm74 2469 8 CO CO NNP cord-015021-pol2qm74 2469 9 by by IN cord-015021-pol2qm74 2469 10 a a DT cord-015021-pol2qm74 2469 11 total total NN cord-015021-pol2qm74 2469 12 of of IN cord-015021-pol2qm74 2469 13 71 71 CD cord-015021-pol2qm74 2469 14 % % NN cord-015021-pol2qm74 2469 15 * * NFP cord-015021-pol2qm74 2469 16 . . . cord-015021-pol2qm74 2470 1 * * NFP cord-015021-pol2qm74 2470 2 : : : cord-015021-pol2qm74 2470 3 p p NN cord-015021-pol2qm74 2470 4 < < XX cord-015021-pol2qm74 2470 5 0.05 0.05 CD cord-015021-pol2qm74 2470 6 . . . cord-015021-pol2qm74 2471 1 Conclusion conclusion NN cord-015021-pol2qm74 2471 2 : : : cord-015021-pol2qm74 2471 3 Is be VBZ cord-015021-pol2qm74 2471 4 the the DT cord-015021-pol2qm74 2471 5 present present JJ cord-015021-pol2qm74 2471 6 model model NN cord-015021-pol2qm74 2471 7 of of IN cord-015021-pol2qm74 2471 8 endotoxemia endotoxemia NN cord-015021-pol2qm74 2471 9 treatment treatment NN cord-015021-pol2qm74 2471 10 with with IN cord-015021-pol2qm74 2471 11 the the DT cord-015021-pol2qm74 2471 12 nitric nitric NN cord-015021-pol2qm74 2471 13 oxide oxide NN cord-015021-pol2qm74 2471 14 synthase synthase NN cord-015021-pol2qm74 2471 15 inhibitor inhibitor NN cord-015021-pol2qm74 2471 16 L l NN cord-015021-pol2qm74 2471 17 - - HYPH cord-015021-pol2qm74 2471 18 NAME name NN cord-015021-pol2qm74 2471 19 markedly markedly RB cord-015021-pol2qm74 2471 20 reduced reduce VBD cord-015021-pol2qm74 2471 21 liver liver NN cord-015021-pol2qm74 2471 22 perfusion perfusion NN cord-015021-pol2qm74 2471 23 and and CC cord-015021-pol2qm74 2471 24 portal portal JJ cord-015021-pol2qm74 2471 25 oxygen oxygen NN cord-015021-pol2qm74 2471 26 supply supply NN cord-015021-pol2qm74 2471 27 . . . cord-015021-pol2qm74 2472 1 This this DT cord-015021-pol2qm74 2472 2 might may MD cord-015021-pol2qm74 2472 3 explain explain VB cord-015021-pol2qm74 2472 4 the the DT cord-015021-pol2qm74 2472 5 increased increase VBN cord-015021-pol2qm74 2472 6 liver liver NN cord-015021-pol2qm74 2472 7 damage damage NN cord-015021-pol2qm74 2472 8 reported report VBN cord-015021-pol2qm74 2472 9 in in IN cord-015021-pol2qm74 2472 10 previous previous JJ cord-015021-pol2qm74 2472 11 studies study NNS cord-015021-pol2qm74 2472 12 using use VBG cord-015021-pol2qm74 2472 13 NO NO NNP cord-015021-pol2qm74 2472 14 - - HYPH cord-015021-pol2qm74 2472 15 inhibitors inhibitor NNS cord-015021-pol2qm74 2472 16 . . . cord-015021-pol2qm74 2473 1 The the DT cord-015021-pol2qm74 2473 2 increase increase NN cord-015021-pol2qm74 2473 3 in in IN cord-015021-pol2qm74 2473 4 transhepatic transhepatic JJ cord-015021-pol2qm74 2473 5 resistance resistance NN cord-015021-pol2qm74 2473 6 found find VBN cord-015021-pol2qm74 2473 7 after after IN cord-015021-pol2qm74 2473 8 L l NN cord-015021-pol2qm74 2473 9 - - HYPH cord-015021-pol2qm74 2473 10 NAME name NN cord-015021-pol2qm74 2473 11 treatment treatment NN cord-015021-pol2qm74 2473 12 will will MD cord-015021-pol2qm74 2473 13 tend tend VB cord-015021-pol2qm74 2473 14 to to TO cord-015021-pol2qm74 2473 15 cause cause VB cord-015021-pol2qm74 2473 16 pooling pooling NN cord-015021-pol2qm74 2473 17 of of IN cord-015021-pol2qm74 2473 18 blood blood NN cord-015021-pol2qm74 2473 19 in in IN cord-015021-pol2qm74 2473 20 the the DT cord-015021-pol2qm74 2473 21 splanchnic splanchnic JJ cord-015021-pol2qm74 2473 22 veins vein NNS cord-015021-pol2qm74 2473 23 , , , cord-015021-pol2qm74 2473 24 resulting result VBG cord-015021-pol2qm74 2473 25 in in IN cord-015021-pol2qm74 2473 26 reduced reduce VBN cord-015021-pol2qm74 2473 27 filling filling NN cord-015021-pol2qm74 2473 28 of of IN cord-015021-pol2qm74 2473 29 the the DT cord-015021-pol2qm74 2473 30 heart heart NN cord-015021-pol2qm74 2473 31 and and CC cord-015021-pol2qm74 2473 32 thus thus RB cord-015021-pol2qm74 2473 33 contribute contribute VB cord-015021-pol2qm74 2473 34 to to IN cord-015021-pol2qm74 2473 35 the the DT cord-015021-pol2qm74 2473 36 observed observed JJ cord-015021-pol2qm74 2473 37 reduction reduction NN cord-015021-pol2qm74 2473 38 in in IN cord-015021-pol2qm74 2473 39 cardiac cardiac JJ cord-015021-pol2qm74 2473 40 output output NN cord-015021-pol2qm74 2473 41 . . . cord-015021-pol2qm74 2474 1 Institute Institute NNP cord-015021-pol2qm74 2474 2 for for IN cord-015021-pol2qm74 2474 3 Surgical Surgical NNP cord-015021-pol2qm74 2474 4 Research Research NNP cord-015021-pol2qm74 2474 5 , , , cord-015021-pol2qm74 2474 6 Rikshospitalet Rikshospitalet NNP cord-015021-pol2qm74 2474 7 , , , cord-015021-pol2qm74 2474 8 The the DT cord-015021-pol2qm74 2474 9 National National NNP cord-015021-pol2qm74 2474 10 Hospital Hospital NNP cord-015021-pol2qm74 2474 11 , , , cord-015021-pol2qm74 2474 12 University University NNP cord-015021-pol2qm74 2474 13 of of IN cord-015021-pol2qm74 2474 14 Oslo Oslo NNP cord-015021-pol2qm74 2474 15 , , , cord-015021-pol2qm74 2474 16 0027 0027 CD cord-015021-pol2qm74 2474 17 Oslo Oslo NNP cord-015021-pol2qm74 2474 18 , , , cord-015021-pol2qm74 2474 19 Norway Norway NNP cord-015021-pol2qm74 2474 20 . . . cord-015021-pol2qm74 2475 1 We -PRON- PRP cord-015021-pol2qm74 2475 2 have have VBP cord-015021-pol2qm74 2475 3 investigated investigate VBN cord-015021-pol2qm74 2475 4 the the DT cord-015021-pol2qm74 2475 5 role role NN cord-015021-pol2qm74 2475 6 of of IN cord-015021-pol2qm74 2475 7 tumour tumour NN cord-015021-pol2qm74 2475 8 necrosis necrosis NN cord-015021-pol2qm74 2475 9 factor factor NN cord-015021-pol2qm74 2475 10 ( ( -LRB- cord-015021-pol2qm74 2475 11 TNF TNF NNP cord-015021-pol2qm74 2475 12 ) ) -RRB- cord-015021-pol2qm74 2475 13 and and CC cord-015021-pol2qm74 2475 14 interleukin interleukin NN cord-015021-pol2qm74 2475 15 - - : cord-015021-pol2qm74 2475 16 i i JJ cord-015021-pol2qm74 2475 17 ( ( -LRB- cord-015021-pol2qm74 2475 18 IL IL NNP cord-015021-pol2qm74 2475 19 - - : cord-015021-pol2qm74 2475 20 I I NNP cord-015021-pol2qm74 2475 21 ) ) -RRB- cord-015021-pol2qm74 2475 22 in in IN cord-015021-pol2qm74 2475 23 the the DT cord-015021-pol2qm74 2475 24 induction induction NN cord-015021-pol2qm74 2475 25 of of IN cord-015021-pol2qm74 2475 26 nitric nitric JJ cord-015021-pol2qm74 2475 27 oxide oxide NN cord-015021-pol2qm74 2475 28 synthase synthase NN cord-015021-pol2qm74 2475 29 ( ( -LRB- cord-015021-pol2qm74 2475 30 NOS NOS NNP cord-015021-pol2qm74 2475 31 ) ) -RRB- cord-015021-pol2qm74 2475 32 by by IN cord-015021-pol2qm74 2475 33 bacterial bacterial JJ cord-015021-pol2qm74 2475 34 endotoxin endotoxin NN cord-015021-pol2qm74 2476 1 ( ( -LRB- cord-015021-pol2qm74 2476 2 lipopolysaccharide lipopolysaccharide NN cord-015021-pol2qm74 2476 3 ; ; : cord-015021-pol2qm74 2476 4 LPS lp NNS cord-015021-pol2qm74 2476 5 ; ; : cord-015021-pol2qm74 2476 6 2 2 CD cord-015021-pol2qm74 2476 7 mg mg NNP cord-015021-pol2qm74 2476 8 kg kg NNP cord-015021-pol2qm74 2476 9 -I -I NNP cord-015021-pol2qm74 2476 10 i.v i.v NNP cord-015021-pol2qm74 2476 11 . . . cord-015021-pol2qm74 2476 12 ) ) -RRB- cord-015021-pol2qm74 2477 1 in in IN cord-015021-pol2qm74 2477 2 vivo vivo NNP cord-015021-pol2qm74 2477 3 . . . cord-015021-pol2qm74 2478 1 In in IN cord-015021-pol2qm74 2478 2 anaesthetized anaesthetized JJ cord-015021-pol2qm74 2478 3 rats rat NNS cord-015021-pol2qm74 2478 4 , , , cord-015021-pol2qm74 2478 5 pretreatment pretreatment NN cord-015021-pol2qm74 2478 6 with with IN cord-015021-pol2qm74 2478 7 a a DT cord-015021-pol2qm74 2478 8 monoclonal monoclonal JJ cord-015021-pol2qm74 2478 9 antibody antibody NN cord-015021-pol2qm74 2478 10 for for IN cord-015021-pol2qm74 2478 11 TNF TNF NNP cord-015021-pol2qm74 2479 1 ( ( -LRB- cord-015021-pol2qm74 2479 2 TNFab tnfab RB cord-015021-pol2qm74 2479 3 ; ; : cord-015021-pol2qm74 2479 4 20 20 CD cord-015021-pol2qm74 2479 5 mg mg NN cord-015021-pol2qm74 2479 6 kg kg NNP cord-015021-pol2qm74 2479 7 -I -I NNP cord-015021-pol2qm74 2479 8 s.c s.c NNP cord-015021-pol2qm74 2479 9 . . NNP cord-015021-pol2qm74 2479 10 , , , cord-015021-pol2qm74 2479 11 at at IN cord-015021-pol2qm74 2479 12 16 16 CD cord-015021-pol2qm74 2479 13 h h NN cord-015021-pol2qm74 2479 14 prior prior RB cord-015021-pol2qm74 2479 15 to to IN cord-015021-pol2qm74 2479 16 LPS LPS NNP cord-015021-pol2qm74 2479 17 ) ) -RRB- cord-015021-pol2qm74 2479 18 or or CC cord-015021-pol2qm74 2479 19 with with IN cord-015021-pol2qm74 2479 20 an an DT cord-015021-pol2qm74 2479 21 IL IL NNP cord-015021-pol2qm74 2479 22 - - HYPH cord-015021-pol2qm74 2479 23 I i NN cord-015021-pol2qm74 2479 24 receptor receptor NN cord-015021-pol2qm74 2479 25 antagonist antagonist NN cord-015021-pol2qm74 2479 26 ( ( -LRB- cord-015021-pol2qm74 2479 27 IL IL NNP cord-015021-pol2qm74 2479 28 - - HYPH cord-015021-pol2qm74 2479 29 Ira Ira NNP cord-015021-pol2qm74 2479 30 ; ; : cord-015021-pol2qm74 2479 31 16 16 CD cord-015021-pol2qm74 2479 32 mg mg NNP cord-015021-pol2qm74 2479 33 / / SYM cord-015021-pol2qm74 2479 34 kg kg NN cord-015021-pol2qm74 2479 35 bolus bolus NN cord-015021-pol2qm74 2479 36 and and CC cord-015021-pol2qm74 2479 37 2.4 2.4 CD cord-015021-pol2qm74 2479 38 mg mg NNP cord-015021-pol2qm74 2479 39 / / SYM cord-015021-pol2qm74 2479 40 kg kg NNP cord-015021-pol2qm74 2479 41 / / SYM cord-015021-pol2qm74 2479 42 h h NN cord-015021-pol2qm74 2479 43 infusion infusion NN cord-015021-pol2qm74 2479 44 ) ) -RRB- cord-015021-pol2qm74 2479 45 ameliorated ameliorate VBD cord-015021-pol2qm74 2479 46 the the DT cord-015021-pol2qm74 2479 47 fall fall NN cord-015021-pol2qm74 2479 48 in in IN cord-015021-pol2qm74 2479 49 mean mean JJ cord-015021-pol2qm74 2479 50 arterial arterial JJ cord-015021-pol2qm74 2479 51 blood blood NN cord-015021-pol2qm74 2479 52 pressure pressure NN cord-015021-pol2qm74 2479 53 ( ( -LRB- cord-015021-pol2qm74 2479 54 MAP MAP NNP cord-015021-pol2qm74 2479 55 ) ) -RRB- cord-015021-pol2qm74 2479 56 at at IN cord-015021-pol2qm74 2479 57 90 90 CD cord-015021-pol2qm74 2479 58 - - SYM cord-015021-pol2qm74 2479 59 180 180 CD cord-015021-pol2qm74 2479 60 min min NN cord-015021-pol2qm74 2479 61 after after IN cord-015021-pol2qm74 2479 62 LPS lp NNS cord-015021-pol2qm74 2479 63 . . . cord-015021-pol2qm74 2480 1 For for IN cord-015021-pol2qm74 2480 2 instance instance NN cord-015021-pol2qm74 2480 3 , , , cord-015021-pol2qm74 2480 4 endotoxaemia endotoxaemia NN cord-015021-pol2qm74 2480 5 for for IN cord-015021-pol2qm74 2480 6 180 180 CD cord-015021-pol2qm74 2480 7 min min NN cord-015021-pol2qm74 2480 8 resulted result VBD cord-015021-pol2qm74 2480 9 in in IN cord-015021-pol2qm74 2480 10 a a DT cord-015021-pol2qm74 2480 11 fall fall NN cord-015021-pol2qm74 2480 12 in in IN cord-015021-pol2qm74 2480 13 MAP MAP NNP cord-015021-pol2qm74 2480 14 from from IN cord-015021-pol2qm74 2480 15 114-+6 114-+6 CD cord-015021-pol2qm74 2480 16 ( ( -LRB- cord-015021-pol2qm74 2480 17 control control NN cord-015021-pol2qm74 2480 18 ) ) -RRB- cord-015021-pol2qm74 2480 19 to to IN cord-015021-pol2qm74 2480 20 79-+4 79-+4 CD cord-015021-pol2qm74 2480 21 mmHg mmHg NNS cord-015021-pol2qm74 2480 22 ( ( -LRB- cord-015021-pol2qm74 2480 23 p<0.01 p<0.01 NNP cord-015021-pol2qm74 2480 24 ; ; , cord-015021-pol2qm74 2480 25 n=8 n=8 NN cord-015021-pol2qm74 2480 26 ) ) -RRB- cord-015021-pol2qm74 2480 27 . . . cord-015021-pol2qm74 2481 1 In in IN cord-015021-pol2qm74 2481 2 contrast contrast NN cord-015021-pol2qm74 2481 3 , , , cord-015021-pol2qm74 2481 4 animals animal NNS cord-015021-pol2qm74 2481 5 pretreated pretreate VBN cord-015021-pol2qm74 2481 6 with with IN cord-015021-pol2qm74 2481 7 TNFab TNFab NNP cord-015021-pol2qm74 2481 8 or or CC cord-015021-pol2qm74 2481 9 IL IL NNP cord-015021-pol2qm74 2481 10 - - HYPH cord-015021-pol2qm74 2481 11 ira ira NNP cord-015021-pol2qm74 2481 12 prior prior RB cord-015021-pol2qm74 2481 13 to to IN cord-015021-pol2qm74 2481 14 LPS LPS NNP cord-015021-pol2qm74 2481 15 injection injection NN cord-015021-pol2qm74 2481 16 maintained maintain VBD cord-015021-pol2qm74 2481 17 significantly significantly RB cord-015021-pol2qm74 2481 18 higher high JJR cord-015021-pol2qm74 2481 19 MAP map NN cord-015021-pol2qm74 2481 20 at at IN cord-015021-pol2qm74 2481 21 180 180 CD cord-015021-pol2qm74 2481 22 min min NN cord-015021-pol2qm74 2481 23 when when WRB cord-015021-pol2qm74 2481 24 compared compare VBN cord-015021-pol2qm74 2481 25 to to IN cord-015021-pol2qm74 2481 26 LPS LPS NNP cord-015021-pol2qm74 2481 27 - - HYPH cord-015021-pol2qm74 2481 28 control control NN cord-015021-pol2qm74 2481 29 : : : cord-015021-pol2qm74 2481 30 118-+3 118-+3 LS cord-015021-pol2qm74 2481 31 mmEg mmEg NNS cord-015021-pol2qm74 2481 32 ( ( -LRB- cord-015021-pol2qm74 2481 33 n=5 n=5 NNP cord-015021-pol2qm74 2481 34 ) ) -RRB- cord-015021-pol2qm74 2481 35 and and CC cord-015021-pol2qm74 2481 36 103-+7 103-+7 CD cord-015021-pol2qm74 2481 37 mmHg mmHg NNS cord-015021-pol2qm74 2481 38 ( ( -LRB- cord-015021-pol2qm74 2481 39 n=5 n=5 NNP cord-015021-pol2qm74 2481 40 ) ) -RRB- cord-015021-pol2qm74 2481 41 , , , cord-015021-pol2qm74 2481 42 respectively respectively RB cord-015021-pol2qm74 2481 43 ( ( -LRB- cord-015021-pol2qm74 2481 44 p<0.01 p<0.01 NNP cord-015021-pol2qm74 2481 45 ) ) -RRB- cord-015021-pol2qm74 2481 46 . . . cord-015021-pol2qm74 2482 1 Three three CD cord-015021-pol2qm74 2482 2 hours hour NNS cord-015021-pol2qm74 2482 3 of of IN cord-015021-pol2qm74 2482 4 endotoxaemia endotoxaemia NN cord-015021-pol2qm74 2482 5 significantly significantly RB cord-015021-pol2qm74 2482 6 reduced reduce VBD cord-015021-pol2qm74 2482 7 the the DT cord-015021-pol2qm74 2482 8 contractile contractile JJ cord-015021-pol2qm74 2482 9 effects effect NNS cord-015021-pol2qm74 2482 10 of of IN cord-015021-pol2qm74 2482 11 noradrenaline noradrenaline NN cord-015021-pol2qm74 2482 12 ( ( -LRB- cord-015021-pol2qm74 2482 13 NA NA NNP cord-015021-pol2qm74 2482 14 ) ) -RRB- cord-015021-pol2qm74 2482 15 in in IN cord-015021-pol2qm74 2482 16 the the DT cord-015021-pol2qm74 2482 17 thoracic thoracic JJ cord-015021-pol2qm74 2482 18 aorta aorta NNP cord-015021-pol2qm74 2482 19 ex ex NN cord-015021-pol2qm74 2482 20 vivo vivo NN cord-015021-pol2qm74 2482 21 . . . cord-015021-pol2qm74 2483 1 The the DT cord-015021-pol2qm74 2483 2 hyporeactivity hyporeactivity NN cord-015021-pol2qm74 2483 3 to to IN cord-015021-pol2qm74 2483 4 NA NA NNP cord-015021-pol2qm74 2483 5 was be VBD cord-015021-pol2qm74 2483 6 partially partially RB cord-015021-pol2qm74 2483 7 restored restore VBN cord-015021-pol2qm74 2483 8 by by IN cord-015021-pol2qm74 2483 9 in in IN cord-015021-pol2qm74 2483 10 vitro vitro FW cord-015021-pol2qm74 2483 11 treatment treatment NN cord-015021-pol2qm74 2483 12 of of IN cord-015021-pol2qm74 2483 13 the the DT cord-015021-pol2qm74 2483 14 vessels vessel NNS cord-015021-pol2qm74 2483 15 with with IN cord-015021-pol2qm74 2483 16 NG NG NNP cord-015021-pol2qm74 2483 17 - - HYPH cord-015021-pol2qm74 2483 18 nitro nitro NNP cord-015021-pol2qm74 2483 19 - - HYPH cord-015021-pol2qm74 2483 20 L l NN cord-015021-pol2qm74 2483 21 - - HYPH cord-015021-pol2qm74 2483 22 arginine arginine NN cord-015021-pol2qm74 2483 23 methyl methyl NN cord-015021-pol2qm74 2483 24 ester ester NN cord-015021-pol2qm74 2483 25 ( ( -LRB- cord-015021-pol2qm74 2483 26 L l NN cord-015021-pol2qm74 2483 27 - - HYPH cord-015021-pol2qm74 2483 28 NAME NAME NNP cord-015021-pol2qm74 2483 29 , , , cord-015021-pol2qm74 2483 30 20 20 CD cord-015021-pol2qm74 2483 31 min min NN cord-015021-pol2qm74 2483 32 , , , cord-015021-pol2qm74 2483 33 3x10 3x10 CD cord-015021-pol2qm74 2483 34 -4 -4 NNP cord-015021-pol2qm74 2483 35 M M NNP cord-015021-pol2qm74 2483 36 ) ) -RRB- cord-015021-pol2qm74 2483 37 . . . cord-015021-pol2qm74 2484 1 Pretreatment pretreatment NN cord-015021-pol2qm74 2484 2 of of IN cord-015021-pol2qm74 2484 3 rats rat NNS cord-015021-pol2qm74 2484 4 with with IN cord-015021-pol2qm74 2484 5 TNFab TNFab NNP cord-015021-pol2qm74 2484 6 or or CC cord-015021-pol2qm74 2484 7 IL IL NNP cord-015021-pol2qm74 2484 8 - - : cord-015021-pol2qm74 2484 9 Ira Ira NNP cord-015021-pol2qm74 2484 10 significantly significantly RB cord-015021-pol2qm74 2484 11 ( ( -LRB- cord-015021-pol2qm74 2484 12 p<0.05 p<0.05 JJ cord-015021-pol2qm74 2484 13 ) ) -RRB- cord-015021-pol2qm74 2484 14 prevented prevent VBD cord-015021-pol2qm74 2484 15 the the DT cord-015021-pol2qm74 2484 16 LPS LPS NNP cord-015021-pol2qm74 2484 17 - - HYPH cord-015021-pol2qm74 2484 18 induced induce VBN cord-015021-pol2qm74 2484 19 hyporeactivity hyporeactivity NN cord-015021-pol2qm74 2484 20 of of IN cord-015021-pol2qm74 2484 21 rat rat NN cord-015021-pol2qm74 2484 22 aortic aortic JJ cord-015021-pol2qm74 2484 23 rings ring NNS cord-015021-pol2qm74 2484 24 ex ex NN cord-015021-pol2qm74 2484 25 vivo vivo NN cord-015021-pol2qm74 2484 26 . . . cord-015021-pol2qm74 2485 1 L L NNP cord-015021-pol2qm74 2485 2 - - HYPH cord-015021-pol2qm74 2485 3 NAME NAME NNP cord-015021-pol2qm74 2485 4 did do VBD cord-015021-pol2qm74 2485 5 not not RB cord-015021-pol2qm74 2485 6 alter alter VB cord-015021-pol2qm74 2485 7 or or CC cord-015021-pol2qm74 2485 8 only only RB cord-015021-pol2qm74 2485 9 slightly slightly RB cord-015021-pol2qm74 2485 10 enhanced enhance VBD cord-015021-pol2qm74 2485 11 the the DT cord-015021-pol2qm74 2485 12 contractions contraction NNS cord-015021-pol2qm74 2485 13 of of IN cord-015021-pol2qm74 2485 14 aortic aortic JJ cord-015021-pol2qm74 2485 15 rings ring NNS cord-015021-pol2qm74 2485 16 obtained obtain VBN cord-015021-pol2qm74 2485 17 from from IN cord-015021-pol2qm74 2485 18 TNFab TNFab NNP cord-015021-pol2qm74 2485 19 or or CC cord-015021-pol2qm74 2485 20 IL IL NNP cord-015021-pol2qm74 2485 21 - - HYPH cord-015021-pol2qm74 2485 22 ira ira NNP cord-015021-pol2qm74 2485 23 treated treat VBD cord-015021-pol2qm74 2485 24 LPS LPS NNP cord-015021-pol2qm74 2485 25 - - HYPH cord-015021-pol2qm74 2485 26 rats rat NNS cord-015021-pol2qm74 2485 27 , , , cord-015021-pol2qm74 2485 28 respectively respectively RB cord-015021-pol2qm74 2485 29 . . . cord-015021-pol2qm74 2486 1 At at IN cord-015021-pol2qm74 2486 2 180 180 CD cord-015021-pol2qm74 2486 3 min min NN cord-015021-pol2qm74 2486 4 after after IN cord-015021-pol2qm74 2486 5 LPS LPS NNP cord-015021-pol2qm74 2486 6 there there EX cord-015021-pol2qm74 2486 7 was be VBD cord-015021-pol2qm74 2486 8 an an DT cord-015021-pol2qm74 2486 9 induction induction NN cord-015021-pol2qm74 2486 10 of of IN cord-015021-pol2qm74 2486 11 calcium calcium NN cord-015021-pol2qm74 2486 12 - - HYPH cord-015021-pol2qm74 2486 13 independent independent JJ cord-015021-pol2qm74 2486 14 NOS NOS NNP cord-015021-pol2qm74 2486 15 activity activity NN cord-015021-pol2qm74 2486 16 in in IN cord-015021-pol2qm74 2486 17 the the DT cord-015021-pol2qm74 2486 18 lung lung NN cord-015021-pol2qm74 2486 19 ( ( -LRB- cord-015021-pol2qm74 2486 20 5.14-+0.57 5.14-+0.57 CD cord-015021-pol2qm74 2486 21 pmol pmol JJ cord-015021-pol2qm74 2486 22 citrulline citrulline NNP cord-015021-pol2qm74 2486 23 / / SYM cord-015021-pol2qm74 2486 24 mg mg NNP cord-015021-pol2qm74 2486 25 / / SYM cord-015021-pol2qm74 2486 26 min min NNP cord-015021-pol2qm74 2486 27 , , , cord-015021-pol2qm74 2486 28 n=8 n=8 NNP cord-015021-pol2qm74 2486 29 ) ) -RRB- cord-015021-pol2qm74 2486 30 , , , cord-015021-pol2qm74 2486 31 which which WDT cord-015021-pol2qm74 2486 32 was be VBD cord-015021-pol2qm74 2486 33 attenuated attenuate VBN cord-015021-pol2qm74 2486 34 by by IN cord-015021-pol2qm74 2486 35 TNFab TNFab NNP cord-015021-pol2qm74 2486 36 and and CC cord-015021-pol2qm74 2486 37 ! ! . cord-015021-pol2qm74 2487 1 L L NNP cord-015021-pol2qm74 2487 2 - - HYPH cord-015021-pol2qm74 2487 3 ira ira NNP cord-015021-pol2qm74 2487 4 by by IN cord-015021-pol2qm74 2487 5 37-+6 37-+6 CD cord-015021-pol2qm74 2487 6 % % NN cord-015021-pol2qm74 2487 7 and and CC cord-015021-pol2qm74 2487 8 46-+6 46-+6 CD cord-015021-pol2qm74 2487 9 % % NN cord-015021-pol2qm74 2487 10 , , , cord-015021-pol2qm74 2487 11 respectively respectively RB cord-015021-pol2qm74 2487 12 ( ( -LRB- cord-015021-pol2qm74 2487 13 n=5 n=5 JJ cord-015021-pol2qm74 2487 14 ; ; : cord-015021-pol2qm74 2487 15 p<0.05 p<0.05 CD cord-015021-pol2qm74 2487 16 ) ) -RRB- cord-015021-pol2qm74 2487 17 . . . cord-015021-pol2qm74 2488 1 Thus thus RB cord-015021-pol2qm74 2488 2 , , , cord-015021-pol2qm74 2488 3 the the DT cord-015021-pol2qm74 2488 4 production production NN cord-015021-pol2qm74 2488 5 of of IN cord-015021-pol2qm74 2488 6 both both CC cord-015021-pol2qm74 2488 7 TNF TNF NNP cord-015021-pol2qm74 2488 8 and and CC cord-015021-pol2qm74 2488 9 IL IL NNP cord-015021-pol2qm74 2488 10 - - : cord-015021-pol2qm74 2488 11 I -PRON- PRP cord-015021-pol2qm74 2488 12 contributes contribute VBZ cord-015021-pol2qm74 2488 13 to to IN cord-015021-pol2qm74 2488 14 the the DT cord-015021-pol2qm74 2488 15 induction induction NN cord-015021-pol2qm74 2488 16 of of IN cord-015021-pol2qm74 2488 17 NOS NOS NNP cord-015021-pol2qm74 2488 18 by by IN cord-015021-pol2qm74 2488 19 LPS LPS NNP cord-015021-pol2qm74 2488 20 in in IN cord-015021-pol2qm74 2488 21 vivo vivo NN cord-015021-pol2qm74 2488 22 . . . cord-015021-pol2qm74 2489 1 The the DT cord-015021-pol2qm74 2489 2 protective protective JJ cord-015021-pol2qm74 2489 3 effect effect NN cord-015021-pol2qm74 2489 4 of of IN cord-015021-pol2qm74 2489 5 agents agent NNS cord-015021-pol2qm74 2489 6 which which WDT cord-015021-pol2qm74 2489 7 inhibit inhibit VBP cord-015021-pol2qm74 2489 8 the the DT cord-015021-pol2qm74 2489 9 release release NN cord-015021-pol2qm74 2489 10 or or CC cord-015021-pol2qm74 2489 11 action action NN cord-015021-pol2qm74 2489 12 of of IN cord-015021-pol2qm74 2489 13 TNF TNF NNP cord-015021-pol2qm74 2489 14 or or CC cord-015021-pol2qm74 2489 15 IL IL NNP cord-015021-pol2qm74 2489 16 - - : cord-015021-pol2qm74 2489 17 I -PRON- PRP cord-015021-pol2qm74 2489 18 in in IN cord-015021-pol2qm74 2489 19 shock shock NN cord-015021-pol2qm74 2489 20 may may MD cord-015021-pol2qm74 2489 21 be be VB cord-015021-pol2qm74 2489 22 , , , cord-015021-pol2qm74 2489 23 in in IN cord-015021-pol2qm74 2489 24 part part NN cord-015021-pol2qm74 2489 25 , , , cord-015021-pol2qm74 2489 26 due due IN cord-015021-pol2qm74 2489 27 to to IN cord-015021-pol2qm74 2489 28 inhibition inhibition NN cord-015021-pol2qm74 2489 29 of of IN cord-015021-pol2qm74 2489 30 NOS NOS NNP cord-015021-pol2qm74 2489 31 induction induction NN cord-015021-pol2qm74 2489 32 . . . cord-015021-pol2qm74 2490 1 Neal Neal NNP cord-015021-pol2qm74 2490 2 Garrison Garrison NNP cord-015021-pol2qm74 2490 3 , , , cord-015021-pol2qm74 2490 4 MD MD NNP cord-015021-pol2qm74 2490 5 Objective Objective NNP cord-015021-pol2qm74 2490 6 : : : cord-015021-pol2qm74 2491 1 Sepsis sepsis NN cord-015021-pol2qm74 2491 2 is be VBZ cord-015021-pol2qm74 2491 3 often often RB cord-015021-pol2qm74 2491 4 accompanied accompany VBN cord-015021-pol2qm74 2491 5 by by IN cord-015021-pol2qm74 2491 6 organ organ NN cord-015021-pol2qm74 2491 7 dysfunction dysfunction NN cord-015021-pol2qm74 2491 8 , , , cord-015021-pol2qm74 2491 9 in in IN cord-015021-pol2qm74 2491 10 part part NN cord-015021-pol2qm74 2491 11 due due IN cord-015021-pol2qm74 2491 12 to to IN cord-015021-pol2qm74 2491 13 impaired impaired JJ cord-015021-pol2qm74 2491 14 microvascular microvascular JJ cord-015021-pol2qm74 2491 15 perfusion perfusion NN cord-015021-pol2qm74 2491 16 . . . cord-015021-pol2qm74 2492 1 Recently recently RB cord-015021-pol2qm74 2492 2 , , , cord-015021-pol2qm74 2492 3 nitric nitric JJ cord-015021-pol2qm74 2492 4 oxide oxide NN cord-015021-pol2qm74 2492 5 ( ( -LRB- cord-015021-pol2qm74 2492 6 NO no UH cord-015021-pol2qm74 2492 7 ) ) -RRB- cord-015021-pol2qm74 2492 8 has have VBZ cord-015021-pol2qm74 2492 9 been be VBN cord-015021-pol2qm74 2492 10 described describe VBN cord-015021-pol2qm74 2492 11 as as IN cord-015021-pol2qm74 2492 12 an an DT cord-015021-pol2qm74 2492 13 important important JJ cord-015021-pol2qm74 2492 14 mediator mediator NN cord-015021-pol2qm74 2492 15 of of IN cord-015021-pol2qm74 2492 16 the the DT cord-015021-pol2qm74 2492 17 hemodynamic hemodynamic JJ cord-015021-pol2qm74 2492 18 changes change NNS cord-015021-pol2qm74 2492 19 of of IN cord-015021-pol2qm74 2492 20 sepsis sepsis NN cord-015021-pol2qm74 2492 21 , , , cord-015021-pol2qm74 2492 22 and and CC cord-015021-pol2qm74 2492 23 NO no DT cord-015021-pol2qm74 2492 24 synthase synthase NN cord-015021-pol2qm74 2492 25 ( ( -LRB- cord-015021-pol2qm74 2492 26 NO NO NNP cord-015021-pol2qm74 2492 27 - - HYPH cord-015021-pol2qm74 2492 28 S S NNP cord-015021-pol2qm74 2492 29 ) ) -RRB- cord-015021-pol2qm74 2492 30 inhibitors inhibitor NNS cord-015021-pol2qm74 2492 31 have have VBP cord-015021-pol2qm74 2492 32 been be VBN cord-015021-pol2qm74 2492 33 advocated advocate VBN cord-015021-pol2qm74 2492 34 for for IN cord-015021-pol2qm74 2492 35 treatment treatment NN cord-015021-pol2qm74 2492 36 of of IN cord-015021-pol2qm74 2492 37 septic septic JJ cord-015021-pol2qm74 2492 38 shock shock NN cord-015021-pol2qm74 2492 39 , , , cord-015021-pol2qm74 2492 40 but but CC cord-015021-pol2qm74 2492 41 their -PRON- PRP$ cord-015021-pol2qm74 2492 42 visceral visceral JJ cord-015021-pol2qm74 2492 43 microcirculatory microcirculatory JJ cord-015021-pol2qm74 2492 44 effects effect NNS cord-015021-pol2qm74 2492 45 are be VBP cord-015021-pol2qm74 2492 46 inadequately inadequately RB cord-015021-pol2qm74 2492 47 characterized characterize VBN cord-015021-pol2qm74 2492 48 . . . cord-015021-pol2qm74 2493 1 We -PRON- PRP cord-015021-pol2qm74 2493 2 postulated postulate VBD cord-015021-pol2qm74 2493 3 that that IN cord-015021-pol2qm74 2493 4 NO NO NNP cord-015021-pol2qm74 2493 5 - - HYPH cord-015021-pol2qm74 2493 6 S s NN cord-015021-pol2qm74 2493 7 inhibition inhibition NN cord-015021-pol2qm74 2493 8 would would MD cord-015021-pol2qm74 2493 9 EXaCErbatE EXaCErbatE NNP cord-015021-pol2qm74 2493 10 the the DT cord-015021-pol2qm74 2493 11 impaired impaired JJ cord-015021-pol2qm74 2493 12 organ organ NN cord-015021-pol2qm74 2493 13 pErfusion perfusion NN cord-015021-pol2qm74 2493 14 of of IN cord-015021-pol2qm74 2493 15 sepsis sepsis NN cord-015021-pol2qm74 2493 16 . . . cord-015021-pol2qm74 2494 1 Methods method NNS cord-015021-pol2qm74 2494 2 : : : cord-015021-pol2qm74 2494 3 Six six CD cord-015021-pol2qm74 2494 4 groups group NNS cord-015021-pol2qm74 2494 5 ofdecerebratE ofdecerebrate VBP cord-015021-pol2qm74 2494 6 rats rat NNS cord-015021-pol2qm74 2494 7 were be VBD cord-015021-pol2qm74 2494 8 studied study VBN cord-015021-pol2qm74 2494 9 . . . cord-015021-pol2qm74 2495 1 Bacteremia Bacteremia NNP cord-015021-pol2qm74 2495 2 was be VBD cord-015021-pol2qm74 2495 3 induced induce VBN cord-015021-pol2qm74 2495 4 with with IN cord-015021-pol2qm74 2495 5 109 109 CD cord-015021-pol2qm74 2495 6 live live JJ cord-015021-pol2qm74 2495 7 E. E. NNP cord-015021-pol2qm74 2495 8 coli coli NNS cord-015021-pol2qm74 2495 9 , , , cord-015021-pol2qm74 2495 10 which which WDT cord-015021-pol2qm74 2495 11 consistently consistently RB cord-015021-pol2qm74 2495 12 increased increase VBD cord-015021-pol2qm74 2495 13 cardiac cardiac JJ cord-015021-pol2qm74 2495 14 output output NN cord-015021-pol2qm74 2495 15 15 15 CD cord-015021-pol2qm74 2495 16 - - SYM cord-015021-pol2qm74 2495 17 20 20 CD cord-015021-pol2qm74 2495 18 % % NN cord-015021-pol2qm74 2495 19 above above IN cord-015021-pol2qm74 2495 20 baseline baseline NN cord-015021-pol2qm74 2495 21 ( ( -LRB- cord-015021-pol2qm74 2495 22 BL BL NNP cord-015021-pol2qm74 2495 23 ) ) -RRB- cord-015021-pol2qm74 2495 24 . . . cord-015021-pol2qm74 2496 1 The the DT cord-015021-pol2qm74 2496 2 NO NO NNP cord-015021-pol2qm74 2496 3 - - HYPH cord-015021-pol2qm74 2496 4 S s NN cord-015021-pol2qm74 2496 5 inhibitor inhibitor NN cord-015021-pol2qm74 2496 6 Nm Nm NNP cord-015021-pol2qm74 2496 7 - - HYPH cord-015021-pol2qm74 2496 8 nitro nitro NNP cord-015021-pol2qm74 2496 9 - - HYPH cord-015021-pol2qm74 2496 10 Larginine larginine JJ cord-015021-pol2qm74 2496 11 methyl methyl NN cord-015021-pol2qm74 2496 12 ester ester NN cord-015021-pol2qm74 2496 13 ( ( -LRB- cord-015021-pol2qm74 2496 14 L L NNP cord-015021-pol2qm74 2496 15 - - HYPH cord-015021-pol2qm74 2496 16 NAME,1 NAME,1 NNP cord-015021-pol2qm74 2496 17 mg mg NNP cord-015021-pol2qm74 2496 18 / / SYM cord-015021-pol2qm74 2496 19 kg kg NNP cord-015021-pol2qm74 2496 20 IV IV NNP cord-015021-pol2qm74 2496 21 ) ) -RRB- cord-015021-pol2qm74 2496 22 , , , cord-015021-pol2qm74 2496 23 prevented prevent VBD cord-015021-pol2qm74 2496 24 this this DT cord-015021-pol2qm74 2496 25 increase increase NN cord-015021-pol2qm74 2496 26 and and CC cord-015021-pol2qm74 2496 27 elevated elevated JJ cord-015021-pol2qm74 2496 28 MAP map NN cord-015021-pol2qm74 2496 29 by by IN cord-015021-pol2qm74 2496 30 25 25 CD cord-015021-pol2qm74 2496 31 - - SYM cord-015021-pol2qm74 2496 32 30 30 CD cord-015021-pol2qm74 2496 33 % % NN cord-015021-pol2qm74 2496 34 . . . cord-015021-pol2qm74 2497 1 In in IN cord-015021-pol2qm74 2497 2 the the DT cord-015021-pol2qm74 2497 3 first first JJ cord-015021-pol2qm74 2497 4 3 3 CD cord-015021-pol2qm74 2497 5 groups group NNS cord-015021-pol2qm74 2497 6 , , , cord-015021-pol2qm74 2497 7 total total JJ cord-015021-pol2qm74 2497 8 hepatic hepatic JJ cord-015021-pol2qm74 2497 9 blood blood NN cord-015021-pol2qm74 2497 10 flow flow NN cord-015021-pol2qm74 2497 11 ( ( -LRB- cord-015021-pol2qm74 2497 12 THBF THBF NNP cord-015021-pol2qm74 2497 13 , , , cord-015021-pol2qm74 2497 14 ml ml NN cord-015021-pol2qm74 2497 15 / / SYM cord-015021-pol2qm74 2497 16 min min NN cord-015021-pol2qm74 2497 17 by by IN cord-015021-pol2qm74 2497 18 time time NN cord-015021-pol2qm74 2497 19 transit transit NNP cord-015021-pol2qm74 2497 20 flowmetry flowmetry NNP cord-015021-pol2qm74 2497 21 ) ) -RRB- cord-015021-pol2qm74 2497 22 and and CC cord-015021-pol2qm74 2497 23 microvascular microvascular JJ cord-015021-pol2qm74 2497 24 perfusion perfusion NN cord-015021-pol2qm74 2497 25 ( ( -LRB- cord-015021-pol2qm74 2497 26 MI MI NNP cord-015021-pol2qm74 2497 27 - - HYPH cord-015021-pol2qm74 2497 28 IBF IBF NNP cord-015021-pol2qm74 2497 29 , , , cord-015021-pol2qm74 2497 30 ¼ ¼ NN cord-015021-pol2qm74 2497 31 BL bl NN cord-015021-pol2qm74 2497 32 by by IN cord-015021-pol2qm74 2497 33 laser laser NN cord-015021-pol2qm74 2497 34 Doppler doppler NN cord-015021-pol2qm74 2497 35 flux flux NN cord-015021-pol2qm74 2497 36 ) ) -RRB- cord-015021-pol2qm74 2497 37 were be VBD cord-015021-pol2qm74 2497 38 measured measure VBN cord-015021-pol2qm74 2497 39 . . . cord-015021-pol2qm74 2498 1 In in IN cord-015021-pol2qm74 2498 2 the the DT cord-015021-pol2qm74 2498 3 other other JJ cord-015021-pol2qm74 2498 4 3 3 CD cord-015021-pol2qm74 2498 5 groups group NNS cord-015021-pol2qm74 2498 6 , , , cord-015021-pol2qm74 2498 7 in in IN cord-015021-pol2qm74 2498 8 vivo vivo NNP cord-015021-pol2qm74 2498 9 videomicroscopy videomicroscopy NNP cord-015021-pol2qm74 2498 10 was be VBD cord-015021-pol2qm74 2498 11 used use VBN cord-015021-pol2qm74 2498 12 to to TO cord-015021-pol2qm74 2498 13 observe observe VB cord-015021-pol2qm74 2498 14 renal renal JJ cord-015021-pol2qm74 2498 15 microvascular microvascular JJ cord-015021-pol2qm74 2498 16 responses response NNS cord-015021-pol2qm74 2498 17 ( ( -LRB- cord-015021-pol2qm74 2498 18 ILA ILA NNP cord-015021-pol2qm74 2498 19 = = SYM cord-015021-pol2qm74 2498 20 interlobular interlobular JJ cord-015021-pol2qm74 2498 21 artery artery NN cord-015021-pol2qm74 2498 22 , , , cord-015021-pol2qm74 2498 23 AFF AFF NNP cord-015021-pol2qm74 2498 24 = = SYM cord-015021-pol2qm74 2498 25 afferent afferent NN cord-015021-pol2qm74 2498 26 arteriole arteriole NN cord-015021-pol2qm74 2498 27 , , , cord-015021-pol2qm74 2498 28 EFF eff NN cord-015021-pol2qm74 2498 29 = = SYM cord-015021-pol2qm74 2498 30 efferent efferent JJ cord-015021-pol2qm74 2498 31 arteriole arteriole NN cord-015021-pol2qm74 2498 32 ; ; : cord-015021-pol2qm74 2498 33 % % NN cord-015021-pol2qm74 2498 34 BL bl NN cord-015021-pol2qm74 2498 35 for for IN cord-015021-pol2qm74 2498 36 all all DT cord-015021-pol2qm74 2498 37 ) ) -RRB- cord-015021-pol2qm74 2498 38 . . . cord-015021-pol2qm74 2499 1 Results result NNS cord-015021-pol2qm74 2499 2 : : : cord-015021-pol2qm74 2500 1 Data datum NNS cord-015021-pol2qm74 2500 2 are be VBP cord-015021-pol2qm74 2500 3 60 60 CD cord-015021-pol2qm74 2500 4 rains rain NNS cord-015021-pol2qm74 2500 5 after after IN cord-015021-pol2qm74 2500 6 E. E. NNP cord-015021-pol2qm74 2500 7 coB. coB. VBD cord-015021-pol2qm74 2500 8 N=5 N=5 NNP cord-015021-pol2qm74 2500 9 - - HYPH cord-015021-pol2qm74 2500 10 7 7 CD cord-015021-pol2qm74 2500 11 / / SYM cord-015021-pol2qm74 2500 12 group group NN cord-015021-pol2qm74 2500 13 . . . cord-015021-pol2qm74 2501 1 * * NFP cord-015021-pol2qm74 2501 2 p<0.05 p<0.05 NN cord-015021-pol2qm74 2501 3 vs vs IN cord-015021-pol2qm74 2501 4 BL BL NNP cord-015021-pol2qm74 2501 5 by by IN cord-015021-pol2qm74 2501 6 REMANOVA REMANOVA NNP cord-015021-pol2qm74 2501 7 and and CC cord-015021-pol2qm74 2501 8 § § CD cord-015021-pol2qm74 2501 9 p<0.05 p<0.05 NN cord-015021-pol2qm74 2501 10 vs vs IN cord-015021-pol2qm74 2501 11 E. E. NNP cord-015021-pol2qm74 2501 12 coli coli NNS cord-015021-pol2qm74 2501 13 alone alone JJ cord-015021-pol2qm74 2501 14 by by IN cord-015021-pol2qm74 2501 15 ANOVA ANOVA NNP cord-015021-pol2qm74 2501 16 . . . cord-015021-pol2qm74 2502 1 EC+L EC+L NNP cord-015021-pol2qm74 2502 2 - - HYPH cord-015021-pol2qm74 2502 3 NAME NAME NNP cord-015021-pol2qm74 2503 1 11-+2 11-+2 CD cord-015021-pol2qm74 2503 2 -57_+10 -57_+10 NN cord-015021-pol2qm74 2503 3 " " '' cord-015021-pol2qm74 2504 1 § § . cord-015021-pol2qm74 2505 1 -45_+4 -45_+4 NNP cord-015021-pol2qm74 2506 1 * * NFP cord-015021-pol2qm74 2506 2 § § NFP cord-015021-pol2qm74 2506 3 -89_+3 -89_+3 : cord-015021-pol2qm74 2507 1 * * NFP cord-015021-pol2qm74 2507 2 § § , cord-015021-pol2qm74 2507 3 -33 -33 NNP cord-015021-pol2qm74 2508 1 +5 +5 NFP cord-015021-pol2qm74 2509 1 * * NFP cord-015021-pol2qm74 2509 2 -20 -20 NFP cord-015021-pol2qm74 2509 3 + + . cord-015021-pol2qm74 2510 1 5 5 LS cord-015021-pol2qm74 2511 1 * * NFP cord-015021-pol2qm74 2511 2 § § . cord-015021-pol2qm74 2511 3 Conclusions conclusion NNS cord-015021-pol2qm74 2511 4 : : : cord-015021-pol2qm74 2511 5 L L NNP cord-015021-pol2qm74 2511 6 - - HYPH cord-015021-pol2qm74 2511 7 NAME NAME NNP cord-015021-pol2qm74 2511 8 administration administration NN cord-015021-pol2qm74 2511 9 in in IN cord-015021-pol2qm74 2511 10 controls control NNS cord-015021-pol2qm74 2511 11 decreased decrease VBD cord-015021-pol2qm74 2511 12 renal renal JJ cord-015021-pol2qm74 2511 13 blood blood NN cord-015021-pol2qm74 2511 14 flow flow NN cord-015021-pol2qm74 2511 15 , , , cord-015021-pol2qm74 2511 16 indicating indicate VBG cord-015021-pol2qm74 2511 17 NO no DT cord-015021-pol2qm74 2511 18 contributes contribute VBZ cord-015021-pol2qm74 2511 19 to to IN cord-015021-pol2qm74 2511 20 basal basal NN cord-015021-pol2qm74 2511 21 renal renal JJ cord-015021-pol2qm74 2511 22 tone tone NN cord-015021-pol2qm74 2511 23 . . . cord-015021-pol2qm74 2512 1 Bacteremia Bacteremia NNP cord-015021-pol2qm74 2512 2 decreased decrease VBD cord-015021-pol2qm74 2512 3 MtlBF MtlBF NNS cord-015021-pol2qm74 2512 4 but but CC cord-015021-pol2qm74 2512 5 not not RB cord-015021-pol2qm74 2512 6 THBF THBF NNP cord-015021-pol2qm74 2512 7 , , , cord-015021-pol2qm74 2512 8 and and CC cord-015021-pol2qm74 2512 9 MI MI NNP cord-015021-pol2qm74 2512 10 - - HYPH cord-015021-pol2qm74 2512 11 IBF IBF NNP cord-015021-pol2qm74 2512 12 was be VBD cord-015021-pol2qm74 2512 13 further further RB cord-015021-pol2qm74 2512 14 impaired impair VBN cord-015021-pol2qm74 2512 15 by by IN cord-015021-pol2qm74 2512 16 NO no DT cord-015021-pol2qm74 2512 17 - - HYPH cord-015021-pol2qm74 2512 18 S s NN cord-015021-pol2qm74 2512 19 inhibition inhibition NN cord-015021-pol2qm74 2512 20 . . . cord-015021-pol2qm74 2513 1 E. E. NNP cord-015021-pol2qm74 2513 2 coli coli NNS cord-015021-pol2qm74 2513 3 caused cause VBD cord-015021-pol2qm74 2513 4 renal renal JJ cord-015021-pol2qm74 2513 5 preglomemlar preglomemlar NN cord-015021-pol2qm74 2513 6 , , , cord-015021-pol2qm74 2513 7 but but CC cord-015021-pol2qm74 2513 8 not not RB cord-015021-pol2qm74 2513 9 postglomerular postglomerular JJ cord-015021-pol2qm74 2513 10 constriction constriction NN cord-015021-pol2qm74 2513 11 and and CC cord-015021-pol2qm74 2513 12 reduced reduced JJ cord-015021-pol2qm74 2513 13 flow flow NN cord-015021-pol2qm74 2513 14 . . . cord-015021-pol2qm74 2514 1 L l NN cord-015021-pol2qm74 2514 2 - - HYPH cord-015021-pol2qm74 2514 3 NAME name NN cord-015021-pol2qm74 2514 4 exacerbated exacerbate VBD cord-015021-pol2qm74 2514 5 these these DT cord-015021-pol2qm74 2514 6 E. E. NNP cord-015021-pol2qm74 2514 7 coli coli NNS cord-015021-pol2qm74 2514 8 - - HYPH cord-015021-pol2qm74 2514 9 induced induce VBN cord-015021-pol2qm74 2514 10 alterations alteration NNS cord-015021-pol2qm74 2514 11 and and CC cord-015021-pol2qm74 2514 12 caused cause VBD cord-015021-pol2qm74 2514 13 EFF eff NN cord-015021-pol2qm74 2514 14 constriction constriction NN cord-015021-pol2qm74 2514 15 . . . cord-015021-pol2qm74 2515 1 These these DT cord-015021-pol2qm74 2515 2 data datum NNS cord-015021-pol2qm74 2515 3 indicate indicate VBP cord-015021-pol2qm74 2515 4 that that IN cord-015021-pol2qm74 2515 5 NO NO NNP cord-015021-pol2qm74 2515 6 - - HYPH cord-015021-pol2qm74 2515 7 S s NN cord-015021-pol2qm74 2515 8 inhibition inhibition NN cord-015021-pol2qm74 2515 9 exacerbates exacerbate VBZ cord-015021-pol2qm74 2515 10 bacteremia bacteremia NN cord-015021-pol2qm74 2515 11 - - HYPH cord-015021-pol2qm74 2515 12 induced induce VBN cord-015021-pol2qm74 2515 13 impairment impairment NN cord-015021-pol2qm74 2515 14 of of IN cord-015021-pol2qm74 2515 15 renal renal JJ cord-015021-pol2qm74 2515 16 and and CC cord-015021-pol2qm74 2515 17 hepatic hepatic JJ cord-015021-pol2qm74 2515 18 blood blood NN cord-015021-pol2qm74 2515 19 flow flow NN cord-015021-pol2qm74 2515 20 , , , cord-015021-pol2qm74 2515 21 suggesting suggest VBG cord-015021-pol2qm74 2515 22 that that IN cord-015021-pol2qm74 2515 23 NO no DT cord-015021-pol2qm74 2515 24 is be VBZ cord-015021-pol2qm74 2515 25 an an DT cord-015021-pol2qm74 2515 26 importam importam NNP cord-015021-pol2qm74 2515 27 compensatory compensatory JJ cord-015021-pol2qm74 2515 28 dilator dilator NN cord-015021-pol2qm74 2515 29 mechanism mechanism NN cord-015021-pol2qm74 2515 30 in in IN cord-015021-pol2qm74 2515 31 these these DT cord-015021-pol2qm74 2515 32 organs organ NNS cord-015021-pol2qm74 2515 33 during during IN cord-015021-pol2qm74 2515 34 sepsis sepsis NN cord-015021-pol2qm74 2515 35 . . . cord-015021-pol2qm74 2516 1 IRF IRF NNP cord-015021-pol2qm74 2516 2 ( ( -LRB- cord-015021-pol2qm74 2516 3 iron iron NN cord-015021-pol2qm74 2516 4 responsive responsive JJ cord-015021-pol2qm74 2516 5 factor factor NN cord-015021-pol2qm74 2516 6 ) ) -RRB- cord-015021-pol2qm74 2516 7 is be VBZ cord-015021-pol2qm74 2516 8 the the DT cord-015021-pol2qm74 2516 9 central central JJ cord-015021-pol2qm74 2516 10 regulatory regulatory JJ cord-015021-pol2qm74 2516 11 protein protein NN cord-015021-pol2qm74 2516 12 of of IN cord-015021-pol2qm74 2516 13 intracellular intracellular JJ cord-015021-pol2qm74 2516 14 iron iron NN cord-015021-pol2qm74 2516 15 metabolism metabolism NN cord-015021-pol2qm74 2516 16 able able JJ cord-015021-pol2qm74 2516 17 to to TO cord-015021-pol2qm74 2516 18 bind bind VB cord-015021-pol2qm74 2516 19 to to IN cord-015021-pol2qm74 2516 20 responsive responsive JJ cord-015021-pol2qm74 2516 21 RNA RNA NNP cord-015021-pol2qm74 2516 22 elements element NNS cord-015021-pol2qm74 2516 23 ( ( -LRB- cord-015021-pol2qm74 2516 24 IREs IREs NNP cord-015021-pol2qm74 2516 25 ) ) -RRB- cord-015021-pol2qm74 2516 26 present present VBP cord-015021-pol2qm74 2516 27 atthe atthe DT cord-015021-pol2qm74 2516 28 5'untranslated 5'untranslated CD cord-015021-pol2qm74 2516 29 region region NN cord-015021-pol2qm74 2516 30 ( ( -LRB- cord-015021-pol2qm74 2516 31 UTR UTR NNP cord-015021-pol2qm74 2516 32 ) ) -RRB- cord-015021-pol2qm74 2516 33 of of IN cord-015021-pol2qm74 2516 34 ferritin ferritin NNP cord-015021-pol2qm74 2516 35 mRNA mRNA NNP cord-015021-pol2qm74 2516 36 and and CC cord-015021-pol2qm74 2516 37 3'UTR 3'utr CD cord-015021-pol2qm74 2516 38 of of IN cord-015021-pol2qm74 2516 39 transferrin transferrin NN cord-015021-pol2qm74 2516 40 receptor receptor NN cord-015021-pol2qm74 2516 41 mRNA mRNA NNP cord-015021-pol2qm74 2516 42 . . . cord-015021-pol2qm74 2517 1 Binding bind VBG cord-015021-pol2qm74 2517 2 of of IN cord-015021-pol2qm74 2517 3 IRF IRF NNP cord-015021-pol2qm74 2517 4 to to IN cord-015021-pol2qm74 2517 5 IREs ires NN cord-015021-pol2qm74 2517 6 results result NNS cord-015021-pol2qm74 2517 7 in in IN cord-015021-pol2qm74 2517 8 repression repression NN cord-015021-pol2qm74 2517 9 of of IN cord-015021-pol2qm74 2517 10 ferritin ferritin NN cord-015021-pol2qm74 2517 11 mRNA mRNA NNP cord-015021-pol2qm74 2517 12 translation translation NN cord-015021-pol2qm74 2517 13 and and CC cord-015021-pol2qm74 2517 14 increased increase VBN cord-015021-pol2qm74 2517 15 stability stability NN cord-015021-pol2qm74 2517 16 of of IN cord-015021-pol2qm74 2517 17 transferrin transferrin NN cord-015021-pol2qm74 2517 18 receptor receptor NN cord-015021-pol2qm74 2517 19 mRNA mrna NN cord-015021-pol2qm74 2517 20 leading lead VBG cord-015021-pol2qm74 2517 21 to to IN cord-015021-pol2qm74 2517 22 enhancement enhancement NN cord-015021-pol2qm74 2517 23 of of IN cord-015021-pol2qm74 2517 24 transferrin transferrin NN cord-015021-pol2qm74 2517 25 receptor receptor NN cord-015021-pol2qm74 2517 26 translation translation NN cord-015021-pol2qm74 2517 27 . . . cord-015021-pol2qm74 2518 1 We -PRON- PRP cord-015021-pol2qm74 2518 2 describe describe VBP cord-015021-pol2qm74 2518 3 here here RB cord-015021-pol2qm74 2518 4 that that IN cord-015021-pol2qm74 2518 5 either either CC cord-015021-pol2qm74 2518 6 tetrahydrobiopterin tetrahydrobiopterin NN cord-015021-pol2qm74 2518 7 dependent dependent JJ cord-015021-pol2qm74 2518 8 stimulation stimulation NN cord-015021-pol2qm74 2518 9 as as RB cord-015021-pol2qm74 2518 10 well well RB cord-015021-pol2qm74 2518 11 as as IN cord-015021-pol2qm74 2518 12 cytokine cytokine NN cord-015021-pol2qm74 2518 13 ( ( -LRB- cord-015021-pol2qm74 2518 14 IFN-~)/lipopolysaccharidemediated ifn-~)/lipopolysaccharidemediated JJ cord-015021-pol2qm74 2518 15 induction induction NN cord-015021-pol2qm74 2518 16 of of IN cord-015021-pol2qm74 2518 17 nitric nitric JJ cord-015021-pol2qm74 2518 18 oxide oxide NN cord-015021-pol2qm74 2518 19 synthase synthase NN cord-015021-pol2qm74 2518 20 activates activate VBZ cord-015021-pol2qm74 2518 21 IRF IRF NNP cord-015021-pol2qm74 2518 22 , , , cord-015021-pol2qm74 2518 23 which which WDT cord-015021-pol2qm74 2518 24 is be VBZ cord-015021-pol2qm74 2518 25 due due JJ cord-015021-pol2qm74 2518 26 to to IN cord-015021-pol2qm74 2518 27 direct direct JJ cord-015021-pol2qm74 2518 28 interaction interaction NN cord-015021-pol2qm74 2518 29 of of IN cord-015021-pol2qm74 2518 30 nitric nitric NN cord-015021-pol2qm74 2518 31 oxide oxide NN cord-015021-pol2qm74 2518 32 with with IN cord-015021-pol2qm74 2518 33 the the DT cord-015021-pol2qm74 2518 34 iron iron NN cord-015021-pol2qm74 2518 35 - - HYPH cord-015021-pol2qm74 2518 36 sulphur sulphur NN cord-015021-pol2qm74 2518 37 - - HYPH cord-015021-pol2qm74 2518 38 cluster cluster NN cord-015021-pol2qm74 2518 39 of of IN cord-015021-pol2qm74 2518 40 IRF IRF NNP cord-015021-pol2qm74 2518 41 . . . cord-015021-pol2qm74 2519 1 This this DT cord-015021-pol2qm74 2519 2 was be VBD cord-015021-pol2qm74 2519 3 shown show VBN cord-015021-pol2qm74 2519 4 by by IN cord-015021-pol2qm74 2519 5 gene gene NN cord-015021-pol2qm74 2519 6 expression expression NN cord-015021-pol2qm74 2519 7 studies study NNS cord-015021-pol2qm74 2519 8 using use VBG cord-015021-pol2qm74 2519 9 a a DT cord-015021-pol2qm74 2519 10 plasmid plasmid NN cord-015021-pol2qm74 2519 11 containing contain VBG cord-015021-pol2qm74 2519 12 a a DT cord-015021-pol2qm74 2519 13 ferritin ferritin NN cord-015021-pol2qm74 2519 14 IRE ire NN cord-015021-pol2qm74 2519 15 and and CC cord-015021-pol2qm74 2519 16 a a DT cord-015021-pol2qm74 2519 17 CAT cat NN cord-015021-pol2qm74 2519 18 indicator indicator NN cord-015021-pol2qm74 2519 19 box box NN cord-015021-pol2qm74 2519 20 which which WDT cord-015021-pol2qm74 2519 21 was be VBD cord-015021-pol2qm74 2519 22 transfected transfecte VBN cord-015021-pol2qm74 2519 23 into into IN cord-015021-pol2qm74 2519 24 K562 k562 CD cord-015021-pol2qm74 2519 25 myelomonocytic myelomonocytic JJ cord-015021-pol2qm74 2519 26 cells cell NNS cord-015021-pol2qm74 2519 27 , , , cord-015021-pol2qm74 2519 28 which which WDT cord-015021-pol2qm74 2519 29 were be VBD cord-015021-pol2qm74 2519 30 shown show VBN cord-015021-pol2qm74 2519 31 to to TO cord-015021-pol2qm74 2519 32 have have VB cord-015021-pol2qm74 2519 33 a a DT cord-015021-pol2qm74 2519 34 constitutive constitutive JJ cord-015021-pol2qm74 2519 35 form form NN cord-015021-pol2qm74 2519 36 of of IN cord-015021-pol2qm74 2519 37 nitric nitric NN cord-015021-pol2qm74 2519 38 oxide oxide NN cord-015021-pol2qm74 2519 39 synthase synthase NN cord-015021-pol2qm74 2519 40 ( ( -LRB- cord-015021-pol2qm74 2519 41 NOS NOS NNP cord-015021-pol2qm74 2519 42 ) ) -RRB- cord-015021-pol2qm74 2519 43 . . . cord-015021-pol2qm74 2520 1 Furthermore furthermore RB cord-015021-pol2qm74 2520 2 , , , cord-015021-pol2qm74 2520 3 the the DT cord-015021-pol2qm74 2520 4 increased increase VBN cord-015021-pol2qm74 2520 5 binding binding NN cord-015021-pol2qm74 2520 6 of of IN cord-015021-pol2qm74 2520 7 1RE 1re CD cord-015021-pol2qm74 2520 8 to to IN cord-015021-pol2qm74 2520 9 IRF IRF NNP cord-015021-pol2qm74 2520 10 due due IN cord-015021-pol2qm74 2520 11 to to IN cord-015021-pol2qm74 2520 12 IRF IRF NNP cord-015021-pol2qm74 2520 13 activation activation NN cord-015021-pol2qm74 2520 14 of of IN cord-015021-pol2qm74 2520 15 IRF IRF NNP cord-015021-pol2qm74 2520 16 by by IN cord-015021-pol2qm74 2520 17 nitric nitric NN cord-015021-pol2qm74 2520 18 oxide oxide NN cord-015021-pol2qm74 2520 19 was be VBD cord-015021-pol2qm74 2520 20 demonstrated demonstrate VBN cord-015021-pol2qm74 2520 21 by by IN cord-015021-pol2qm74 2520 22 gel gel NN cord-015021-pol2qm74 2520 23 shift shift NN cord-015021-pol2qm74 2520 24 assays assay NNS cord-015021-pol2qm74 2520 25 . . . cord-015021-pol2qm74 2521 1 IRF IRF NNP cord-015021-pol2qm74 2521 2 activity activity NN cord-015021-pol2qm74 2521 3 was be VBD cord-015021-pol2qm74 2521 4 much much RB cord-015021-pol2qm74 2521 5 more more RBR cord-015021-pol2qm74 2521 6 increased increase VBN cord-015021-pol2qm74 2521 7 in in IN cord-015021-pol2qm74 2521 8 cellular cellular JJ cord-015021-pol2qm74 2521 9 extracts extract NNS cord-015021-pol2qm74 2521 10 from from IN cord-015021-pol2qm74 2521 11 murine murine JJ cord-015021-pol2qm74 2521 12 macrophages macrophage NNS cord-015021-pol2qm74 2521 13 ( ( -LRB- cord-015021-pol2qm74 2521 14 J774 J774 NNS cord-015021-pol2qm74 2521 15 ) ) -RRB- cord-015021-pol2qm74 2521 16 where where WRB cord-015021-pol2qm74 2521 17 a a DT cord-015021-pol2qm74 2521 18 cytokine cytokine NN cord-015021-pol2qm74 2521 19 inducible inducible JJ cord-015021-pol2qm74 2521 20 form form NN cord-015021-pol2qm74 2521 21 of of IN cord-015021-pol2qm74 2521 22 NOS NOS NNP cord-015021-pol2qm74 2521 23 has have VBZ cord-015021-pol2qm74 2521 24 been be VBN cord-015021-pol2qm74 2521 25 characterized characterize VBN cord-015021-pol2qm74 2521 26 earlier early RBR cord-015021-pol2qm74 2521 27 as as IN cord-015021-pol2qm74 2521 28 compared compare VBN cord-015021-pol2qm74 2521 29 with with IN cord-015021-pol2qm74 2521 30 IRF IRF NNP cord-015021-pol2qm74 2521 31 activity activity NN cord-015021-pol2qm74 2521 32 in in IN cord-015021-pol2qm74 2521 33 K562 k562 CD cord-015021-pol2qm74 2521 34 cells cell NNS cord-015021-pol2qm74 2521 35 , , , cord-015021-pol2qm74 2521 36 where where WRB cord-015021-pol2qm74 2521 37 NOS NOS NNP cord-015021-pol2qm74 2521 38 was be VBD cord-015021-pol2qm74 2521 39 stimulated stimulate VBN cord-015021-pol2qm74 2521 40 by by IN cord-015021-pol2qm74 2521 41 increasing increase VBG cord-015021-pol2qm74 2521 42 the the DT cord-015021-pol2qm74 2521 43 availability availability NN cord-015021-pol2qm74 2521 44 of of IN cord-015021-pol2qm74 2521 45 the the DT cord-015021-pol2qm74 2521 46 essential essential JJ cord-015021-pol2qm74 2521 47 NOS NOS NNP cord-015021-pol2qm74 2521 48 cofactor cofactor NN cord-015021-pol2qm74 2521 49 5,6,7,8-tetrahydrobiopterin 5,6,7,8-tetrahydrobiopterin CD cord-015021-pol2qm74 2521 50 . . . cord-015021-pol2qm74 2522 1 We -PRON- PRP cord-015021-pol2qm74 2522 2 then then RB cord-015021-pol2qm74 2522 3 demonstrated demonstrate VBD cord-015021-pol2qm74 2522 4 that that IN cord-015021-pol2qm74 2522 5 activation activation NN cord-015021-pol2qm74 2522 6 of of IN cord-015021-pol2qm74 2522 7 IRF IRF NNP cord-015021-pol2qm74 2522 8 by by IN cord-015021-pol2qm74 2522 9 nitric nitric NN cord-015021-pol2qm74 2522 10 oxide oxide NN cord-015021-pol2qm74 2522 11 is be VBZ cord-015021-pol2qm74 2522 12 accompanied accompany VBN cord-015021-pol2qm74 2522 13 by by IN cord-015021-pol2qm74 2522 14 alterations alteration NNS cord-015021-pol2qm74 2522 15 in in IN cord-015021-pol2qm74 2522 16 ferritin ferritin NN cord-015021-pol2qm74 2522 17 translation translation NN cord-015021-pol2qm74 2522 18 as as IN cord-015021-pol2qm74 2522 19 checked check VBN cord-015021-pol2qm74 2522 20 by by IN cord-015021-pol2qm74 2522 21 metabolic metabolic JJ cord-015021-pol2qm74 2522 22 labeling labeling NN cord-015021-pol2qm74 2522 23 and and CC cord-015021-pol2qm74 2522 24 immunoprecipitation immunoprecipitation NN cord-015021-pol2qm74 2522 25 . . . cord-015021-pol2qm74 2523 1 These these DT cord-015021-pol2qm74 2523 2 results result NNS cord-015021-pol2qm74 2523 3 suggest suggest VBP cord-015021-pol2qm74 2523 4 a a DT cord-015021-pol2qm74 2523 5 reasonable reasonable JJ cord-015021-pol2qm74 2523 6 mechanism mechanism NN cord-015021-pol2qm74 2523 7 for for IN cord-015021-pol2qm74 2523 8 the the DT cord-015021-pol2qm74 2523 9 regulation regulation NN cord-015021-pol2qm74 2523 10 of of IN cord-015021-pol2qm74 2523 11 iron iron NN cord-015021-pol2qm74 2523 12 disturbances disturbance NNS cord-015021-pol2qm74 2523 13 under under IN cord-015021-pol2qm74 2523 14 chronic chronic JJ cord-015021-pol2qm74 2523 15 inflammatory inflammatory JJ cord-015021-pol2qm74 2523 16 disorders disorder NNS cord-015021-pol2qm74 2523 17 , , , cord-015021-pol2qm74 2523 18 characterized characterize VBN cord-015021-pol2qm74 2523 19 by by IN cord-015021-pol2qm74 2523 20 increased increase VBN cord-015021-pol2qm74 2523 21 concentration concentration NN cord-015021-pol2qm74 2523 22 of of IN cord-015021-pol2qm74 2523 23 immune immune JJ cord-015021-pol2qm74 2523 24 activation activation NN cord-015021-pol2qm74 2523 25 parameters parameter NNS cord-015021-pol2qm74 2523 26 like like IN cord-015021-pol2qm74 2523 27 IFN-5or IFN-5or NNP cord-015021-pol2qm74 2523 28 neopterin neopterin NN cord-015021-pol2qm74 2523 29 and and CC cord-015021-pol2qm74 2523 30 low low JJ cord-015021-pol2qm74 2523 31 serum serum NN cord-015021-pol2qm74 2523 32 iron iron NN cord-015021-pol2qm74 2523 33 and and CC cord-015021-pol2qm74 2523 34 hemoglobin hemoglobin NN cord-015021-pol2qm74 2523 35 concentrations concentration NNS cord-015021-pol2qm74 2523 36 . . . cord-015021-pol2qm74 2524 1 Taken take VBN cord-015021-pol2qm74 2524 2 Nitric Nitric NNP cord-015021-pol2qm74 2524 3 oxide oxide NN cord-015021-pol2qm74 2524 4 , , , cord-015021-pol2qm74 2524 5 NO no UH cord-015021-pol2qm74 2524 6 , , , cord-015021-pol2qm74 2524 7 the the DT cord-015021-pol2qm74 2524 8 putative putative JJ cord-015021-pol2qm74 2524 9 endothelial endothelial JJ cord-015021-pol2qm74 2524 10 derived derive VBN cord-015021-pol2qm74 2524 11 relaxant relaxant NN cord-015021-pol2qm74 2524 12 factor factor NN cord-015021-pol2qm74 2524 13 , , , cord-015021-pol2qm74 2524 14 EDRF EDRF NNP cord-015021-pol2qm74 2524 15 , , , cord-015021-pol2qm74 2524 16 has have VBZ cord-015021-pol2qm74 2524 17 been be VBN cord-015021-pol2qm74 2524 18 shown show VBN cord-015021-pol2qm74 2524 19 to to TO cord-015021-pol2qm74 2524 20 be be VB cord-015021-pol2qm74 2524 21 a a DT cord-015021-pol2qm74 2524 22 potent potent JJ cord-015021-pol2qm74 2524 23 inhibitor inhibitor NN cord-015021-pol2qm74 2524 24 ofplatelet ofplatelet NN cord-015021-pol2qm74 2524 25 aggregation aggregation NN cord-015021-pol2qm74 2524 26 in in IN cord-015021-pol2qm74 2524 27 vitro vitro FW cord-015021-pol2qm74 2524 28 . . . cord-015021-pol2qm74 2525 1 In in IN cord-015021-pol2qm74 2525 2 vivo vivo NN cord-015021-pol2qm74 2525 3 evidence evidence NN cord-015021-pol2qm74 2525 4 however however RB cord-015021-pol2qm74 2525 5 , , , cord-015021-pol2qm74 2525 6 is be VBZ cord-015021-pol2qm74 2525 7 scarce scarce JJ cord-015021-pol2qm74 2525 8 . . . cord-015021-pol2qm74 2526 1 Accumulation accumulation NN cord-015021-pol2qm74 2526 2 of of IN cord-015021-pol2qm74 2526 3 platelets platelet NNS cord-015021-pol2qm74 2526 4 in in IN cord-015021-pol2qm74 2526 5 the the DT cord-015021-pol2qm74 2526 6 lungs lung NNS cord-015021-pol2qm74 2526 7 has have VBZ cord-015021-pol2qm74 2526 8 been be VBN cord-015021-pol2qm74 2526 9 shown show VBN cord-015021-pol2qm74 2526 10 to to TO cord-015021-pol2qm74 2526 11 occur occur VB cord-015021-pol2qm74 2526 12 during during IN cord-015021-pol2qm74 2526 13 extracorporeal extracorporeal JJ cord-015021-pol2qm74 2526 14 circulation circulation NN cord-015021-pol2qm74 2526 15 . . . cord-015021-pol2qm74 2527 1 The the DT cord-015021-pol2qm74 2527 2 aim aim NN cord-015021-pol2qm74 2527 3 of of IN cord-015021-pol2qm74 2527 4 the the DT cord-015021-pol2qm74 2527 5 present present JJ cord-015021-pol2qm74 2527 6 study study NN cord-015021-pol2qm74 2527 7 was be VBD cord-015021-pol2qm74 2527 8 to to TO cord-015021-pol2qm74 2527 9 investigate investigate VB cord-015021-pol2qm74 2527 10 the the DT cord-015021-pol2qm74 2527 11 effect effect NN cord-015021-pol2qm74 2527 12 of of IN cord-015021-pol2qm74 2527 13 inhaled inhale VBN cord-015021-pol2qm74 2527 14 NO no RB cord-015021-pol2qm74 2527 15 on on IN cord-015021-pol2qm74 2527 16 this this DT cord-015021-pol2qm74 2527 17 reaction reaction NN cord-015021-pol2qm74 2527 18 . . . cord-015021-pol2qm74 2528 1 Materials material NNS cord-015021-pol2qm74 2528 2 and and CC cord-015021-pol2qm74 2528 3 methods method NNS cord-015021-pol2qm74 2528 4 : : : cord-015021-pol2qm74 2528 5 The the DT cord-015021-pol2qm74 2528 6 animals animal NNS cord-015021-pol2qm74 2528 7 were be VBD cord-015021-pol2qm74 2528 8 divided divide VBN cord-015021-pol2qm74 2528 9 into into IN cord-015021-pol2qm74 2528 10 two two CD cord-015021-pol2qm74 2528 11 groups group NNS cord-015021-pol2qm74 2528 12 , , , cord-015021-pol2qm74 2528 13 each each DT cord-015021-pol2qm74 2528 14 consisting consist VBG cord-015021-pol2qm74 2528 15 of of IN cord-015021-pol2qm74 2528 16 7 7 CD cord-015021-pol2qm74 2528 17 pigs pig NNS cord-015021-pol2qm74 2528 18 . . . cord-015021-pol2qm74 2529 1 Platelets platelet NNS cord-015021-pol2qm74 2529 2 were be VBD cord-015021-pol2qm74 2529 3 selectively selectively RB cord-015021-pol2qm74 2529 4 labelled label VBN cord-015021-pol2qm74 2529 5 with with IN cord-015021-pol2qm74 2529 6 lUln luln NN cord-015021-pol2qm74 2529 7 - - HYPH cord-015021-pol2qm74 2529 8 oxine oxine NN cord-015021-pol2qm74 2529 9 . . . cord-015021-pol2qm74 2530 1 Dialysis dialysis NN cord-015021-pol2qm74 2530 2 was be VBD cord-015021-pol2qm74 2530 3 instituted institute VBN cord-015021-pol2qm74 2530 4 via via IN cord-015021-pol2qm74 2530 5 catheters catheter NNS cord-015021-pol2qm74 2530 6 in in IN cord-015021-pol2qm74 2530 7 the the DT cord-015021-pol2qm74 2530 8 femoral femoral JJ cord-015021-pol2qm74 2530 9 vessels vessel NNS cord-015021-pol2qm74 2530 10 . . . cord-015021-pol2qm74 2531 1 In in IN cord-015021-pol2qm74 2531 2 group group NN cord-015021-pol2qm74 2531 3 1 1 CD cord-015021-pol2qm74 2531 4 , , , cord-015021-pol2qm74 2531 5 NO no UH cord-015021-pol2qm74 2531 6 , , , cord-015021-pol2qm74 2531 7 50 50 CD cord-015021-pol2qm74 2531 8 ppm ppm NN cord-015021-pol2qm74 2531 9 , , , cord-015021-pol2qm74 2531 10 was be VBD cord-015021-pol2qm74 2531 11 added add VBN cord-015021-pol2qm74 2531 12 to to IN cord-015021-pol2qm74 2531 13 the the DT cord-015021-pol2qm74 2531 14 inhaled inhale VBN cord-015021-pol2qm74 2531 15 gas gas NN cord-015021-pol2qm74 2531 16 from from IN cord-015021-pol2qm74 2531 17 the the DT cord-015021-pol2qm74 2531 18 start start NN cord-015021-pol2qm74 2531 19 of of IN cord-015021-pol2qm74 2531 20 dialysis dialysis NN cord-015021-pol2qm74 2531 21 . . . cord-015021-pol2qm74 2532 1 In in IN cord-015021-pol2qm74 2532 2 group group NN cord-015021-pol2qm74 2532 3 2 2 CD cord-015021-pol2qm74 2532 4 NO no NN cord-015021-pol2qm74 2532 5 was be VBD cord-015021-pol2qm74 2532 6 not not RB cord-015021-pol2qm74 2532 7 given give VBN cord-015021-pol2qm74 2532 8 . . . cord-015021-pol2qm74 2533 1 The the DT cord-015021-pol2qm74 2533 2 activity activity NN cord-015021-pol2qm74 2533 3 over over IN cord-015021-pol2qm74 2533 4 the the DT cord-015021-pol2qm74 2533 5 lungs lung NNS cord-015021-pol2qm74 2533 6 was be VBD cord-015021-pol2qm74 2533 7 followed follow VBN cord-015021-pol2qm74 2533 8 dynamically dynamically RB cord-015021-pol2qm74 2533 9 with with IN cord-015021-pol2qm74 2533 10 a a DT cord-015021-pol2qm74 2533 11 gamma gamma JJ cord-015021-pol2qm74 2533 12 camera camera NN cord-015021-pol2qm74 2533 13 . . . cord-015021-pol2qm74 2534 1 Central central JJ cord-015021-pol2qm74 2534 2 hemodynamics hemodynamic NNS cord-015021-pol2qm74 2534 3 was be VBD cord-015021-pol2qm74 2534 4 monitored monitor VBN cord-015021-pol2qm74 2534 5 via via IN cord-015021-pol2qm74 2534 6 a a DT cord-015021-pol2qm74 2534 7 Swan Swan NNP cord-015021-pol2qm74 2534 8 -Ganz -Ganz NNP cord-015021-pol2qm74 2534 9 catheter catheter NN cord-015021-pol2qm74 2534 10 . . . cord-015021-pol2qm74 2535 1 Results result NNS cord-015021-pol2qm74 2535 2 : : : cord-015021-pol2qm74 2536 1 The the DT cord-015021-pol2qm74 2536 2 activity activity NN cord-015021-pol2qm74 2536 3 was be VBD cord-015021-pol2qm74 2536 4 significantly significantly RB cord-015021-pol2qm74 2536 5 lower low JJR cord-015021-pol2qm74 2536 6 in in IN cord-015021-pol2qm74 2536 7 group group NN cord-015021-pol2qm74 2536 8 1 1 CD cord-015021-pol2qm74 2536 9 , , , cord-015021-pol2qm74 2536 10 from from IN cord-015021-pol2qm74 2536 11 2 2 CD cord-015021-pol2qm74 2536 12 minutes minute NNS cord-015021-pol2qm74 2536 13 after after IN cord-015021-pol2qm74 2536 14 start start NN cord-015021-pol2qm74 2536 15 of of IN cord-015021-pol2qm74 2536 16 dialysis dialysis NN cord-015021-pol2qm74 2536 17 and and CC cord-015021-pol2qm74 2536 18 onwards onwards RB cord-015021-pol2qm74 2536 19 , , , cord-015021-pol2qm74 2536 20 indicating indicate VBG cord-015021-pol2qm74 2536 21 diminished diminish VBN cord-015021-pol2qm74 2536 22 accumulation accumulation NN cord-015021-pol2qm74 2536 23 of of IN cord-015021-pol2qm74 2536 24 platelets platelet NNS cord-015021-pol2qm74 2536 25 in in IN cord-015021-pol2qm74 2536 26 the the DT cord-015021-pol2qm74 2536 27 lungs lung NNS cord-015021-pol2qm74 2536 28 . . . cord-015021-pol2qm74 2537 1 Parallel parallel JJ cord-015021-pol2qm74 2537 2 to to IN cord-015021-pol2qm74 2537 3 this this DT cord-015021-pol2qm74 2537 4 the the DT cord-015021-pol2qm74 2537 5 hemodynamic hemodynamic JJ cord-015021-pol2qm74 2537 6 response response NN cord-015021-pol2qm74 2537 7 in in IN cord-015021-pol2qm74 2537 8 terms term NNS cord-015021-pol2qm74 2537 9 of of IN cord-015021-pol2qm74 2537 10 increased increase VBN cord-015021-pol2qm74 2537 11 pulmonary pulmonary JJ cord-015021-pol2qm74 2537 12 artery artery NN cord-015021-pol2qm74 2537 13 pressure pressure NN cord-015021-pol2qm74 2537 14 and and CC cord-015021-pol2qm74 2537 15 pulmonary pulmonary JJ cord-015021-pol2qm74 2537 16 vascular vascular JJ cord-015021-pol2qm74 2537 17 resistance resistance NN cord-015021-pol2qm74 2537 18 was be VBD cord-015021-pol2qm74 2537 19 blunted blunt VBN cord-015021-pol2qm74 2537 20 in in IN cord-015021-pol2qm74 2537 21 this this DT cord-015021-pol2qm74 2537 22 group group NN cord-015021-pol2qm74 2537 23 Conclusion conclusion NN cord-015021-pol2qm74 2537 24 : : : cord-015021-pol2qm74 2537 25 Inhaled inhale VBN cord-015021-pol2qm74 2537 26 NO no RB cord-015021-pol2qm74 2537 27 in in IN cord-015021-pol2qm74 2537 28 this this DT cord-015021-pol2qm74 2537 29 model model NN cord-015021-pol2qm74 2537 30 seems seem VBZ cord-015021-pol2qm74 2537 31 to to TO cord-015021-pol2qm74 2537 32 affect affect VB cord-015021-pol2qm74 2537 33 pulmonary pulmonary JJ cord-015021-pol2qm74 2537 34 platelet platelet NN cord-015021-pol2qm74 2537 35 sequestration sequestration NN cord-015021-pol2qm74 2537 36 . . . cord-015021-pol2qm74 2538 1 An an DT cord-015021-pol2qm74 2538 2 associated associate VBN cord-015021-pol2qm74 2538 3 attenuation attenuation NN cord-015021-pol2qm74 2538 4 of of IN cord-015021-pol2qm74 2538 5 the the DT cord-015021-pol2qm74 2538 6 changes change NNS cord-015021-pol2qm74 2538 7 in in IN cord-015021-pol2qm74 2538 8 central central JJ cord-015021-pol2qm74 2538 9 hemodynamics hemodynamic NNS cord-015021-pol2qm74 2538 10 was be VBD cord-015021-pol2qm74 2538 11 also also RB cord-015021-pol2qm74 2538 12 seen see VBN cord-015021-pol2qm74 2538 13 . . . cord-015021-pol2qm74 2539 1 Previous previous JJ cord-015021-pol2qm74 2539 2 studies study NNS cord-015021-pol2qm74 2539 3 from from IN cord-015021-pol2qm74 2539 4 our -PRON- PRP$ cord-015021-pol2qm74 2539 5 laboratory laboratory NN cord-015021-pol2qm74 2539 6 have have VBP cord-015021-pol2qm74 2539 7 demonstrated demonstrate VBN cord-015021-pol2qm74 2539 8 that that IN cord-015021-pol2qm74 2539 9 vascular vascular JJ cord-015021-pol2qm74 2539 10 contractility contractility NN cord-015021-pol2qm74 2539 11 decreased decrease VBD cord-015021-pol2qm74 2539 12 in in IN cord-015021-pol2qm74 2539 13 endothelium endothelium NN cord-015021-pol2qm74 2539 14 - - HYPH cord-015021-pol2qm74 2539 15 intact intact JJ cord-015021-pol2qm74 2539 16 blood blood NN cord-015021-pol2qm74 2539 17 vessel vessel NN cord-015021-pol2qm74 2539 18 rings ring VBZ cord-015021-pol2qm74 2539 19 in in IN cord-015021-pol2qm74 2539 20 early early JJ cord-015021-pol2qm74 2539 21 and and CC cord-015021-pol2qm74 2539 22 late late JJ cord-015021-pol2qm74 2539 23 stages stage NNS cord-015021-pol2qm74 2539 24 of of IN cord-015021-pol2qm74 2539 25 sepsis sepsis NN cord-015021-pol2qm74 2539 26 . . . cord-015021-pol2qm74 2540 1 Although although IN cord-015021-pol2qm74 2540 2 endothelium endothelium NN cord-015021-pol2qm74 2540 3 removal removal NN cord-015021-pol2qm74 2540 4 in in IN cord-015021-pol2qm74 2540 5 early early JJ cord-015021-pol2qm74 2540 6 sepsis sepsis NN cord-015021-pol2qm74 2540 7 restored restore VBD cord-015021-pol2qm74 2540 8 vascular vascular JJ cord-015021-pol2qm74 2540 9 contraction contraction NN cord-015021-pol2qm74 2540 10 , , , cord-015021-pol2qm74 2540 11 the the DT cord-015021-pol2qm74 2540 12 depressed depressed JJ cord-015021-pol2qm74 2540 13 smooth smooth JJ cord-015021-pol2qm74 2540 14 muscle muscle NN cord-015021-pol2qm74 2540 15 contractility contractility NN cord-015021-pol2qm74 2540 16 observed observe VBN cord-015021-pol2qm74 2540 17 in in IN cord-015021-pol2qm74 2540 18 late late JJ cord-015021-pol2qm74 2540 19 sepsis sepsis NN cord-015021-pol2qm74 2540 20 was be VBD cord-015021-pol2qm74 2540 21 not not RB cord-015021-pol2qm74 2540 22 restored restore VBN cord-015021-pol2qm74 2540 23 by by IN cord-015021-pol2qm74 2540 24 endothelium endothelium NN cord-015021-pol2qm74 2540 25 removal removal NN cord-015021-pol2qm74 2540 26 . . . cord-015021-pol2qm74 2541 1 This this DT cord-015021-pol2qm74 2541 2 indicates indicate VBZ cord-015021-pol2qm74 2541 3 that that IN cord-015021-pol2qm74 2541 4 impairment impairment NN cord-015021-pol2qm74 2541 5 of of IN cord-015021-pol2qm74 2541 6 smooth smooth JJ cord-015021-pol2qm74 2541 7 muscleper muscleper NN cord-015021-pol2qm74 2541 8 se se FW cord-015021-pol2qm74 2541 9 may may MD cord-015021-pol2qm74 2541 10 be be VB cord-015021-pol2qm74 2541 11 responsible responsible JJ cord-015021-pol2qm74 2541 12 for for IN cord-015021-pol2qm74 2541 13 such such JJ cord-015021-pol2qm74 2541 14 dysfunction dysfunction NN cord-015021-pol2qm74 2541 15 in in IN cord-015021-pol2qm74 2541 16 late late JJ cord-015021-pol2qm74 2541 17 sepsis sepsis NN cord-015021-pol2qm74 2541 18 . . . cord-015021-pol2qm74 2542 1 The the DT cord-015021-pol2qm74 2542 2 aim aim NN cord-015021-pol2qm74 2542 3 of of IN cord-015021-pol2qm74 2542 4 this this DT cord-015021-pol2qm74 2542 5 study study NN cord-015021-pol2qm74 2542 6 , , , cord-015021-pol2qm74 2542 7 therefore therefore RB cord-015021-pol2qm74 2542 8 , , , cord-015021-pol2qm74 2542 9 was be VBD cord-015021-pol2qm74 2542 10 to to TO cord-015021-pol2qm74 2542 11 determine determine VB cord-015021-pol2qm74 2542 12 whether whether IN cord-015021-pol2qm74 2542 13 or or CC cord-015021-pol2qm74 2542 14 not not RB cord-015021-pol2qm74 2542 15 smooth smooth JJ cord-015021-pol2qm74 2542 16 muscle muscle NN cord-015021-pol2qm74 2542 17 - - HYPH cord-015021-pol2qm74 2542 18 derived derive VBN cord-015021-pol2qm74 2542 19 nitric nitric NN cord-015021-pol2qm74 2542 20 oxide oxide NN cord-015021-pol2qm74 2542 21 ( ( -LRB- cord-015021-pol2qm74 2542 22 NO no UH cord-015021-pol2qm74 2542 23 ) ) -RRB- cord-015021-pol2qm74 2542 24 plays play VBZ cord-015021-pol2qm74 2542 25 a a DT cord-015021-pol2qm74 2542 26 role role NN cord-015021-pol2qm74 2542 27 in in IN cord-015021-pol2qm74 2542 28 producing produce VBG cord-015021-pol2qm74 2542 29 vascular vascular JJ cord-015021-pol2qm74 2542 30 smooth smooth JJ cord-015021-pol2qm74 2542 31 muscle muscle NN cord-015021-pol2qm74 2542 32 dysfunction dysfunction NN cord-015021-pol2qm74 2542 33 during during IN cord-015021-pol2qm74 2542 34 late late JJ cord-015021-pol2qm74 2542 35 stages stage NNS cord-015021-pol2qm74 2542 36 of of IN cord-015021-pol2qm74 2542 37 sepsis sepsis NN cord-015021-pol2qm74 2542 38 . . . cord-015021-pol2qm74 2543 1 To to TO cord-015021-pol2qm74 2543 2 study study VB cord-015021-pol2qm74 2543 3 this this DT cord-015021-pol2qm74 2543 4 , , , cord-015021-pol2qm74 2543 5 rats rat NNS cord-015021-pol2qm74 2543 6 ( ( -LRB- cord-015021-pol2qm74 2543 7 250 250 CD cord-015021-pol2qm74 2543 8 - - SYM cord-015021-pol2qm74 2543 9 300 300 CD cord-015021-pol2qm74 2543 10 g g NN cord-015021-pol2qm74 2543 11 , , , cord-015021-pol2qm74 2543 12 n=4 n=4 JJ cord-015021-pol2qm74 2543 13 - - HYPH cord-015021-pol2qm74 2543 14 5 5 CD cord-015021-pol2qm74 2543 15 / / SYM cord-015021-pol2qm74 2543 16 group group NN cord-015021-pol2qm74 2543 17 ) ) -RRB- cord-015021-pol2qm74 2543 18 were be VBD cord-015021-pol2qm74 2543 19 subjected subject VBN cord-015021-pol2qm74 2543 20 to to IN cord-015021-pol2qm74 2543 21 sepsis sepsis NN cord-015021-pol2qm74 2543 22 by by IN cord-015021-pol2qm74 2543 23 cecal cecal JJ cord-015021-pol2qm74 2543 24 ligation ligation NN cord-015021-pol2qm74 2543 25 and and CC cord-015021-pol2qm74 2543 26 puncture puncture NN cord-015021-pol2qm74 2543 27 ( ( -LRB- cord-015021-pol2qm74 2543 28 CLP CLP NNP cord-015021-pol2qm74 2543 29 ) ) -RRB- cord-015021-pol2qm74 2543 30 . . . cord-015021-pol2qm74 2544 1 Septic septic JJ cord-015021-pol2qm74 2544 2 and and CC cord-015021-pol2qm74 2544 3 shamoperated shamoperated JJ cord-015021-pol2qm74 2544 4 rats rat NNS cord-015021-pol2qm74 2544 5 then then RB cord-015021-pol2qm74 2544 6 received receive VBD cord-015021-pol2qm74 2544 7 3 3 CD cord-015021-pol2qm74 2544 8 rrd/100 rrd/100 NNS cord-015021-pol2qm74 2544 9 g g NNP cord-015021-pol2qm74 2544 10 BW BW NNP cord-015021-pol2qm74 2544 11 normal normal JJ cord-015021-pol2qm74 2544 12 saline saline NN cord-015021-pol2qm74 2544 13 . . . cord-015021-pol2qm74 2545 1 The the DT cord-015021-pol2qm74 2545 2 animals animal NNS cord-015021-pol2qm74 2545 3 were be VBD cord-015021-pol2qm74 2545 4 killed kill VBN cord-015021-pol2qm74 2545 5 at at IN cord-015021-pol2qm74 2545 6 10 10 CD cord-015021-pol2qm74 2545 7 , , , cord-015021-pol2qm74 2545 8 20 20 CD cord-015021-pol2qm74 2545 9 , , , cord-015021-pol2qm74 2545 10 or or CC cord-015021-pol2qm74 2545 11 35 35 CD cord-015021-pol2qm74 2545 12 h h NN cord-015021-pol2qm74 2545 13 post post NN cord-015021-pol2qm74 2545 14 - - JJ cord-015021-pol2qm74 2545 15 CLP CLP NNP cord-015021-pol2qm74 2545 16 ( ( -LRB- cord-015021-pol2qm74 2545 17 10 10 CD cord-015021-pol2qm74 2545 18 h h NN cord-015021-pol2qm74 2545 19 post post NN cord-015021-pol2qm74 2545 20 - - JJ cord-015021-pol2qm74 2545 21 CLP clp NN cord-015021-pol2qm74 2545 22 = = SYM cord-015021-pol2qm74 2545 23 early early JJ cord-015021-pol2qm74 2545 24 sepsis sepsis NN cord-015021-pol2qm74 2545 25 ; ; : cord-015021-pol2qm74 2545 26 20 20 CD cord-015021-pol2qm74 2545 27 - - SYM cord-015021-pol2qm74 2545 28 35 35 CD cord-015021-pol2qm74 2545 29 h h NN cord-015021-pol2qm74 2545 30 post post NN cord-015021-pol2qm74 2545 31 - - JJ cord-015021-pol2qm74 2545 32 CLP clp JJ cord-015021-pol2qm74 2545 33 = = SYM cord-015021-pol2qm74 2545 34 late late JJ cord-015021-pol2qm74 2545 35 sepsis sepsis NN cord-015021-pol2qm74 2545 36 ) ) -RRB- cord-015021-pol2qm74 2545 37 , , , cord-015021-pol2qm74 2545 38 and and CC cord-015021-pol2qm74 2545 39 thoracic thoracic JJ cord-015021-pol2qm74 2545 40 aortic aortic JJ cord-015021-pol2qm74 2545 41 rings ring NNS cord-015021-pol2qm74 2545 42 were be VBD cord-015021-pol2qm74 2545 43 prepared prepare VBN cord-015021-pol2qm74 2545 44 for for IN cord-015021-pol2qm74 2545 45 contraction contraction NN cord-015021-pol2qm74 2545 46 studies study NNS cord-015021-pol2qm74 2545 47 using use VBG cord-015021-pol2qm74 2545 48 organ organ NN cord-015021-pol2qm74 2545 49 chambers chamber NNS cord-015021-pol2qm74 2545 50 . . . cord-015021-pol2qm74 2546 1 The the DT cord-015021-pol2qm74 2546 2 complete complete JJ cord-015021-pol2qm74 2546 3 removal removal NN cord-015021-pol2qm74 2546 4 of of IN cord-015021-pol2qm74 2546 5 endothelial endothelial JJ cord-015021-pol2qm74 2546 6 cells cell NNS cord-015021-pol2qm74 2546 7 was be VBD cord-015021-pol2qm74 2546 8 tested test VBN cord-015021-pol2qm74 2546 9 by by IN cord-015021-pol2qm74 2546 10 the the DT cord-015021-pol2qm74 2546 11 absence absence NN cord-015021-pol2qm74 2546 12 of of IN cord-015021-pol2qm74 2546 13 any any DT cord-015021-pol2qm74 2546 14 significant significant JJ cord-015021-pol2qm74 2546 15 acetylcholine acetylcholine NN cord-015021-pol2qm74 2546 16 - - HYPH cord-015021-pol2qm74 2546 17 induced induce VBN cord-015021-pol2qm74 2546 18 vascular vascular JJ cord-015021-pol2qm74 2546 19 relaxation relaxation NN cord-015021-pol2qm74 2546 20 . . . cord-015021-pol2qm74 2547 1 Contractile Contractile NNP cord-015021-pol2qm74 2547 2 responses response NNS cord-015021-pol2qm74 2547 3 to to IN cord-015021-pol2qm74 2547 4 norepinephrine norepinephrine NN cord-015021-pol2qm74 2547 5 ( ( -LRB- cord-015021-pol2qm74 2547 6 NE NE NNP cord-015021-pol2qm74 2547 7 , , , cord-015021-pol2qm74 2547 8 10 10 CD cord-015021-pol2qm74 2547 9 9 9 CD cord-015021-pol2qm74 2547 10 to to TO cord-015021-pol2qm74 2547 11 10 10 CD cord-015021-pol2qm74 2547 12 -5 -5 NNP cord-015021-pol2qm74 2547 13 M M NNP cord-015021-pol2qm74 2547 14 ) ) -RRB- cord-015021-pol2qm74 2547 15 were be VBD cord-015021-pol2qm74 2547 16 determined determine VBN cord-015021-pol2qm74 2547 17 in in IN cord-015021-pol2qm74 2547 18 the the DT cord-015021-pol2qm74 2547 19 aortic aortic JJ cord-015021-pol2qm74 2547 20 rings ring NNS cord-015021-pol2qm74 2547 21 without without IN cord-015021-pol2qm74 2547 22 intact intact JJ cord-015021-pol2qm74 2547 23 endothelium endothelium NN cord-015021-pol2qm74 2547 24 . . . cord-015021-pol2qm74 2548 1 NG NG NNP cord-015021-pol2qm74 2548 2 - - HYPH cord-015021-pol2qm74 2548 3 monomethyl monomethyl NNP cord-015021-pol2qm74 2549 1 -L -L : cord-015021-pol2qm74 2549 2 - - HYPH cord-015021-pol2qm74 2549 3 arginine arginine NN cord-015021-pol2qm74 2550 1 ( ( -LRB- cord-015021-pol2qm74 2550 2 L L NNP cord-015021-pol2qm74 2550 3 - - HYPH cord-015021-pol2qm74 2550 4 NMMA NMMA NNP cord-015021-pol2qm74 2550 5 , , , cord-015021-pol2qm74 2550 6 300/~M 300/~m CD cord-015021-pol2qm74 2550 7 , , , cord-015021-pol2qm74 2550 8 an an DT cord-015021-pol2qm74 2550 9 inhibitor inhibitor NN cord-015021-pol2qm74 2550 10 of of IN cord-015021-pol2qm74 2550 11 NO no DT cord-015021-pol2qm74 2550 12 synthase synthase NN cord-015021-pol2qm74 2550 13 ) ) -RRB- cord-015021-pol2qm74 2550 14 was be VBD cord-015021-pol2qm74 2550 15 then then RB cord-015021-pol2qm74 2550 16 added add VBN cord-015021-pol2qm74 2550 17 to to IN cord-015021-pol2qm74 2550 18 the the DT cord-015021-pol2qm74 2550 19 organ organ NN cord-015021-pol2qm74 2550 20 chamber chamber NN cord-015021-pol2qm74 2550 21 and and CC cord-015021-pol2qm74 2550 22 NE NE NNP cord-015021-pol2qm74 2550 23 - - HYPH cord-015021-pol2qm74 2550 24 induced induce VBN cord-015021-pol2qm74 2550 25 peak peak NN cord-015021-pol2qm74 2550 26 contraction contraction NN cord-015021-pol2qm74 2550 27 was be VBD cord-015021-pol2qm74 2550 28 determined determine VBN cord-015021-pol2qm74 2550 29 before before IN cord-015021-pol2qm74 2550 30 and and CC cord-015021-pol2qm74 2550 31 after after IN cord-015021-pol2qm74 2550 32 the the DT cord-015021-pol2qm74 2550 33 addition addition NN cord-015021-pol2qm74 2550 34 of of IN cord-015021-pol2qm74 2550 35 L L NNP cord-015021-pol2qm74 2550 36 - - HYPH cord-015021-pol2qm74 2550 37 NMMA NMMA NNP cord-015021-pol2qm74 2550 38 . . . cord-015021-pol2qm74 2551 1 The the DT cord-015021-pol2qm74 2551 2 peak peak NN cord-015021-pol2qm74 2551 3 contraction contraction NN cord-015021-pol2qm74 2551 4 ( ( -LRB- cord-015021-pol2qm74 2551 5 rag rag NN cord-015021-pol2qm74 2551 6 / / SYM cord-015021-pol2qm74 2551 7 rag rag NN cord-015021-pol2qm74 2551 8 tissue tissue NN cord-015021-pol2qm74 2551 9 , , , cord-015021-pol2qm74 2551 10 mean_+SEM mean_+SEM NNP cord-015021-pol2qm74 2551 11 ) ) -RRB- cord-015021-pol2qm74 2551 12 is be VBZ cord-015021-pol2qm74 2551 13 shown show VBN cord-015021-pol2qm74 2551 14 below below IN cord-015021-pol2qm74 2551 15 : : : cord-015021-pol2qm74 2551 16 The the DT cord-015021-pol2qm74 2551 17 results result NNS cord-015021-pol2qm74 2551 18 indicate indicate VBP cord-015021-pol2qm74 2551 19 that that IN cord-015021-pol2qm74 2551 20 the the DT cord-015021-pol2qm74 2551 21 addition addition NN cord-015021-pol2qm74 2551 22 of of IN cord-015021-pol2qm74 2551 23 L L NNP cord-015021-pol2qm74 2551 24 - - HYPH cord-015021-pol2qm74 2551 25 NMMA NMMA NNP cord-015021-pol2qm74 2551 26 did do VBD cord-015021-pol2qm74 2551 27 not not RB cord-015021-pol2qm74 2551 28 significantly significantly RB cord-015021-pol2qm74 2551 29 affect affect VB cord-015021-pol2qm74 2551 30 NE NE NNP cord-015021-pol2qm74 2551 31 - - HYPH cord-015021-pol2qm74 2551 32 lnduced lnduce VBN cord-015021-pol2qm74 2551 33 peak peak NN cord-015021-pol2qm74 2551 34 contraction contraction NN cord-015021-pol2qm74 2551 35 in in IN cord-015021-pol2qm74 2551 36 endothelium endothelium NN cord-015021-pol2qm74 2551 37 - - HYPH cord-015021-pol2qm74 2551 38 denuded denude VBN cord-015021-pol2qm74 2551 39 vessel vessel NN cord-015021-pol2qm74 2551 40 rings ring NNS cord-015021-pol2qm74 2551 41 at at IN cord-015021-pol2qm74 2551 42 10 10 CD cord-015021-pol2qm74 2551 43 and and CC cord-015021-pol2qm74 2551 44 20 20 CD cord-015021-pol2qm74 2551 45 h h NN cord-015021-pol2qm74 2551 46 after after IN cord-015021-pol2qm74 2551 47 CLP CLP NNP cord-015021-pol2qm74 2551 48 . . . cord-015021-pol2qm74 2552 1 In in IN cord-015021-pol2qm74 2552 2 contrast contrast NN cord-015021-pol2qm74 2552 3 , , , cord-015021-pol2qm74 2552 4 L L NNP cord-015021-pol2qm74 2552 5 - - HYPH cord-015021-pol2qm74 2552 6 NMMA NMMA NNP cord-015021-pol2qm74 2552 7 administration administration NN cord-015021-pol2qm74 2552 8 produces produce VBZ cord-015021-pol2qm74 2552 9 an an DT cord-015021-pol2qm74 2552 10 18 18 CD cord-015021-pol2qm74 2552 11 % % NN cord-015021-pol2qm74 2552 12 increase increase NN cord-015021-pol2qm74 2552 13 ( ( -LRB- cord-015021-pol2qm74 2552 14 P<0.05 P<0.05 NNS cord-015021-pol2qm74 2552 15 ) ) -RRB- cord-015021-pol2qm74 2552 16 in in IN cord-015021-pol2qm74 2552 17 peak peak NN cord-015021-pol2qm74 2552 18 contraction contraction NN cord-015021-pol2qm74 2552 19 during during IN cord-015021-pol2qm74 2552 20 late late JJ cord-015021-pol2qm74 2552 21 sepsis sepsis NN cord-015021-pol2qm74 2552 22 . . . cord-015021-pol2qm74 2553 1 Therefore therefore RB cord-015021-pol2qm74 2553 2 , , , cord-015021-pol2qm74 2553 3 the the DT cord-015021-pol2qm74 2553 4 vascular vascular JJ cord-015021-pol2qm74 2553 5 smooth smooth JJ cord-015021-pol2qm74 2553 6 muscle muscle NN cord-015021-pol2qm74 2553 7 contractile contractile JJ cord-015021-pol2qm74 2553 8 dysfunction dysfunction NN cord-015021-pol2qm74 2553 9 observed observe VBD cord-015021-pol2qm74 2553 10 at at IN cord-015021-pol2qm74 2553 11 35 35 CD cord-015021-pol2qm74 2553 12 h h NN cord-015021-pol2qm74 2553 13 post post NN cord-015021-pol2qm74 2553 14 - - NN cord-015021-pol2qm74 2553 15 CLP CLP NNP cord-015021-pol2qm74 2553 16 is be VBZ cord-015021-pol2qm74 2553 17 partially partially RB cord-015021-pol2qm74 2553 18 due due JJ cord-015021-pol2qm74 2553 19 to to IN cord-015021-pol2qm74 2553 20 smooth smooth JJ cord-015021-pol2qm74 2553 21 muscle muscle NN cord-015021-pol2qm74 2553 22 - - HYPH cord-015021-pol2qm74 2553 23 derived derive VBN cord-015021-pol2qm74 2553 24 NO no RB cord-015021-pol2qm74 2553 25 over over IN cord-015021-pol2qm74 2553 26 - - HYPH cord-015021-pol2qm74 2553 27 production production NN cord-015021-pol2qm74 2553 28 . . . cord-015021-pol2qm74 2554 1 Thus thus RB cord-015021-pol2qm74 2554 2 , , , cord-015021-pol2qm74 2554 3 unlike unlike IN cord-015021-pol2qm74 2554 4 macrophages macrophage NNS cord-015021-pol2qm74 2554 5 in in IN cord-015021-pol2qm74 2554 6 which which WDT cord-015021-pol2qm74 2554 7 inducible inducible JJ cord-015021-pol2qm74 2554 8 nitric nitric NN cord-015021-pol2qm74 2554 9 oxide oxide NN cord-015021-pol2qm74 2554 10 synthase synthase NN cord-015021-pol2qm74 2554 11 ( ( -LRB- cord-015021-pol2qm74 2554 12 iNOS inos NN cord-015021-pol2qm74 2554 13 ) ) -RRB- cord-015021-pol2qm74 2554 14 is be VBZ cord-015021-pol2qm74 2554 15 observed observe VBN cord-015021-pol2qm74 2554 16 in in IN cord-015021-pol2qm74 2554 17 early early JJ cord-015021-pol2qm74 2554 18 sepsis sepsis NN cord-015021-pol2qm74 2554 19 , , , cord-015021-pol2qm74 2554 20 the the DT cord-015021-pol2qm74 2554 21 iNOS inos NN cord-015021-pol2qm74 2554 22 in in IN cord-015021-pol2qm74 2554 23 vascular vascular JJ cord-015021-pol2qm74 2554 24 smooth smooth JJ cord-015021-pol2qm74 2554 25 muscle muscle NN cord-015021-pol2qm74 2554 26 appears appear VBZ cord-015021-pol2qm74 2554 27 prominent prominent JJ cord-015021-pol2qm74 2554 28 only only RB cord-015021-pol2qm74 2554 29 in in IN cord-015021-pol2qm74 2554 30 the the DT cord-015021-pol2qm74 2554 31 late late JJ cord-015021-pol2qm74 2554 32 stages stage NNS cord-015021-pol2qm74 2554 33 of of IN cord-015021-pol2qm74 2554 34 sepsis sepsis NN cord-015021-pol2qm74 2554 35 . . . cord-015021-pol2qm74 2555 1 In in IN cord-015021-pol2qm74 2555 2 three three CD cord-015021-pol2qm74 2555 3 cases case NNS cord-015021-pol2qm74 2555 4 of of IN cord-015021-pol2qm74 2555 5 human human JJ cord-015021-pol2qm74 2555 6 septic septic JJ cord-015021-pol2qm74 2555 7 shock shock NN cord-015021-pol2qm74 2555 8 in in IN cord-015021-pol2qm74 2555 9 which which WDT cord-015021-pol2qm74 2555 10 NG NG NNP cord-015021-pol2qm74 2555 11 - - HYPH cord-015021-pol2qm74 2555 12 monomethyI monomethyI NNP cord-015021-pol2qm74 2555 13 - - HYPH cord-015021-pol2qm74 2555 14 L l NN cord-015021-pol2qm74 2555 15 - - HYPH cord-015021-pol2qm74 2555 16 Arginine Arginine NNP cord-015021-pol2qm74 2555 17 , , , cord-015021-pol2qm74 2555 18 ( ( -LRB- cord-015021-pol2qm74 2555 19 L L NNP cord-015021-pol2qm74 2555 20 - - HYPH cord-015021-pol2qm74 2555 21 NMMA NMMA NNP cord-015021-pol2qm74 2555 22 ) ) -RRB- cord-015021-pol2qm74 2556 1 a a DT cord-015021-pol2qm74 2556 2 nitric nitric NN cord-015021-pol2qm74 2556 3 - - HYPH cord-015021-pol2qm74 2556 4 oxide oxide NN cord-015021-pol2qm74 2556 5 - - HYPH cord-015021-pol2qm74 2556 6 synthase synthase NN cord-015021-pol2qm74 2556 7 - - HYPH cord-015021-pol2qm74 2556 8 inhibitor inhibitor NN cord-015021-pol2qm74 2556 9 was be VBD cord-015021-pol2qm74 2556 10 applied apply VBN cord-015021-pol2qm74 2556 11 , , , cord-015021-pol2qm74 2556 12 we -PRON- PRP cord-015021-pol2qm74 2556 13 isolated isolate VBD cord-015021-pol2qm74 2556 14 three three CD cord-015021-pol2qm74 2556 15 completely completely RB cord-015021-pol2qm74 2556 16 different different JJ cord-015021-pol2qm74 2556 17 types type NNS cord-015021-pol2qm74 2556 18 of of IN cord-015021-pol2qm74 2556 19 pathogens pathogen NNS cord-015021-pol2qm74 2556 20 : : : cord-015021-pol2qm74 2556 21 Candida Candida NNP cord-015021-pol2qm74 2556 22 , , , cord-015021-pol2qm74 2556 23 Pseudomonas Pseudomonas NNP cord-015021-pol2qm74 2556 24 aeruginose aeruginose NNP cord-015021-pol2qm74 2556 25 and and CC cord-015021-pol2qm74 2556 26 multiresistant multiresistant NN cord-015021-pol2qm74 2556 27 coagulase coagulase NN cord-015021-pol2qm74 2556 28 - - HYPH cord-015021-pol2qm74 2556 29 negative negative JJ cord-015021-pol2qm74 2556 30 staphylococci staphylococcus NNS cord-015021-pol2qm74 2556 31 . . . cord-015021-pol2qm74 2557 1 This this DT cord-015021-pol2qm74 2557 2 observation observation NN cord-015021-pol2qm74 2557 3 suggests suggest VBZ cord-015021-pol2qm74 2557 4 that that IN cord-015021-pol2qm74 2557 5 endotoxin endotoxin NN cord-015021-pol2qm74 2557 6 alone alone RB cord-015021-pol2qm74 2557 7 is be VBZ cord-015021-pol2qm74 2557 8 not not RB cord-015021-pol2qm74 2557 9 the the DT cord-015021-pol2qm74 2557 10 main main JJ cord-015021-pol2qm74 2557 11 factor factor NN cord-015021-pol2qm74 2557 12 triggering trigger VBG cord-015021-pol2qm74 2557 13 hypotension hypotension NN cord-015021-pol2qm74 2557 14 in in IN cord-015021-pol2qm74 2557 15 septic septic JJ cord-015021-pol2qm74 2557 16 shock shock NN cord-015021-pol2qm74 2557 17 by by IN cord-015021-pol2qm74 2557 18 the the DT cord-015021-pol2qm74 2557 19 nitric nitric NN cord-015021-pol2qm74 2557 20 oxide oxide NN cord-015021-pol2qm74 2557 21 pathway pathway NN cord-015021-pol2qm74 2557 22 . . . cord-015021-pol2qm74 2558 1 In in IN cord-015021-pol2qm74 2558 2 a a DT cord-015021-pol2qm74 2558 3 68-years 68-years CD cord-015021-pol2qm74 2558 4 - - HYPH cord-015021-pol2qm74 2558 5 old old JJ cord-015021-pol2qm74 2558 6 woman woman NN cord-015021-pol2qm74 2558 7 in in IN cord-015021-pol2qm74 2558 8 severe severe JJ cord-015021-pol2qm74 2558 9 septic septic JJ cord-015021-pol2qm74 2558 10 shock shock NN cord-015021-pol2qm74 2558 11 due due IN cord-015021-pol2qm74 2558 12 to to IN cord-015021-pol2qm74 2558 13 a a DT cord-015021-pol2qm74 2558 14 Candida Candida NNP cord-015021-pol2qm74 2558 15 and and CC cord-015021-pol2qm74 2558 16 Pseudomonas Pseudomonas NNP cord-015021-pol2qm74 2558 17 aeruginosa aeruginosa NN cord-015021-pol2qm74 2558 18 infection infection NN cord-015021-pol2qm74 2558 19 complicated complicate VBN cord-015021-pol2qm74 2558 20 by by IN cord-015021-pol2qm74 2558 21 adult adult NN cord-015021-pol2qm74 2558 22 - - HYPH cord-015021-pol2qm74 2558 23 respiratorydistress respiratorydistress NN cord-015021-pol2qm74 2558 24 - - HYPH cord-015021-pol2qm74 2558 25 syndrome syndrome NN cord-015021-pol2qm74 2558 26 conditions condition NNS cord-015021-pol2qm74 2558 27 deteriorated deteriorate VBD cord-015021-pol2qm74 2558 28 despite despite IN cord-015021-pol2qm74 2558 29 adequate adequate JJ cord-015021-pol2qm74 2558 30 conventional conventional JJ cord-015021-pol2qm74 2558 31 therapy therapy NN cord-015021-pol2qm74 2558 32 . . . cord-015021-pol2qm74 2559 1 In in IN cord-015021-pol2qm74 2559 2 this this DT cord-015021-pol2qm74 2559 3 trial trial NN cord-015021-pol2qm74 2559 4 , , , cord-015021-pol2qm74 2559 5 effects effect NNS cord-015021-pol2qm74 2559 6 of of IN cord-015021-pol2qm74 2559 7 L L NNP cord-015021-pol2qm74 2559 8 - - HYPH cord-015021-pol2qm74 2559 9 NMMA NMMA NNP cord-015021-pol2qm74 2559 10 on on IN cord-015021-pol2qm74 2559 11 cytokin cytokin NN cord-015021-pol2qm74 2559 12 - - HYPH cord-015021-pol2qm74 2559 13 levels level NNS cord-015021-pol2qm74 2559 14 were be VBD cord-015021-pol2qm74 2559 15 investigated investigate VBN cord-015021-pol2qm74 2559 16 . . . cord-015021-pol2qm74 2560 1 The the DT cord-015021-pol2qm74 2560 2 study study NN cord-015021-pol2qm74 2560 3 - - HYPH cord-015021-pol2qm74 2560 4 protocol protocol NN cord-015021-pol2qm74 2560 5 was be VBD cord-015021-pol2qm74 2560 6 approved approve VBN cord-015021-pol2qm74 2560 7 by by IN cord-015021-pol2qm74 2560 8 the the DT cord-015021-pol2qm74 2560 9 ethical ethical JJ cord-015021-pol2qm74 2560 10 committee committee NN cord-015021-pol2qm74 2560 11 of of IN cord-015021-pol2qm74 2560 12 the the DT cord-015021-pol2qm74 2560 13 Department Department NNP cord-015021-pol2qm74 2560 14 of of IN cord-015021-pol2qm74 2560 15 Surgery Surgery NNP cord-015021-pol2qm74 2560 16 . . . cord-015021-pol2qm74 2561 1 After after IN cord-015021-pol2qm74 2561 2 two two CD cord-015021-pol2qm74 2561 3 boll boll NNS cord-015021-pol2qm74 2561 4 of of IN cord-015021-pol2qm74 2561 5 200 200 CD cord-015021-pol2qm74 2561 6 mg mg NN cord-015021-pol2qm74 2561 7 of of IN cord-015021-pol2qm74 2561 8 L L NNP cord-015021-pol2qm74 2561 9 - - HYPH cord-015021-pol2qm74 2561 10 NMMA NMMA NNP cord-015021-pol2qm74 2561 11 , , , cord-015021-pol2qm74 2561 12 a a DT cord-015021-pol2qm74 2561 13 continuous continuous JJ cord-015021-pol2qm74 2561 14 infusion infusion NN cord-015021-pol2qm74 2561 15 was be VBD cord-015021-pol2qm74 2561 16 installed instal VBN cord-015021-pol2qm74 2561 17 ( ( -LRB- cord-015021-pol2qm74 2561 18 0.05 0.05 CD cord-015021-pol2qm74 2561 19 mg mg NNP cord-015021-pol2qm74 2561 20 / / SYM cord-015021-pol2qm74 2561 21 minute minute NN cord-015021-pol2qm74 2561 22 and and CC cord-015021-pol2qm74 2561 23 kg kg NN cord-015021-pol2qm74 2561 24 body body NN cord-015021-pol2qm74 2561 25 weight weight NN cord-015021-pol2qm74 2561 26 L L NNP cord-015021-pol2qm74 2561 27 - - HYPH cord-015021-pol2qm74 2561 28 NMMA NMMA NNP cord-015021-pol2qm74 2561 29 ) ) -RRB- cord-015021-pol2qm74 2561 30 . . . cord-015021-pol2qm74 2562 1 As as IN cord-015021-pol2qm74 2562 2 expected expect VBN cord-015021-pol2qm74 2562 3 mean mean VBP cord-015021-pol2qm74 2562 4 arterial arterial JJ cord-015021-pol2qm74 2562 5 blood blood NN cord-015021-pol2qm74 2562 6 pressure pressure NN cord-015021-pol2qm74 2562 7 rose rise VBD cord-015021-pol2qm74 2562 8 ( ( -LRB- cord-015021-pol2qm74 2562 9 62 62 CD cord-015021-pol2qm74 2562 10 to to TO cord-015021-pol2qm74 2562 11 134 134 CD cord-015021-pol2qm74 2562 12 mmHg mmHg NNS cord-015021-pol2qm74 2562 13 } } -RRB- cord-015021-pol2qm74 2562 14 , , , cord-015021-pol2qm74 2562 15 heart heart NN cord-015021-pol2qm74 2562 16 rate rate NN cord-015021-pol2qm74 2562 17 stayed stay VBD cord-015021-pol2qm74 2562 18 stable stable JJ cord-015021-pol2qm74 2562 19 ( ( -LRB- cord-015021-pol2qm74 2562 20 124 124 CD cord-015021-pol2qm74 2562 21 + + SYM cord-015021-pol2qm74 2562 22 4 4 CD cord-015021-pol2qm74 2562 23 b b NN cord-015021-pol2qm74 2562 24 / / SYM cord-015021-pol2qm74 2562 25 rain rain NN cord-015021-pol2qm74 2562 26 ) ) -RRB- cord-015021-pol2qm74 2562 27 , , , cord-015021-pol2qm74 2562 28 systemic systemic JJ cord-015021-pol2qm74 2562 29 vascular vascular JJ cord-015021-pol2qm74 2562 30 resistance resistance NN cord-015021-pol2qm74 2562 31 increased increase VBD cord-015021-pol2qm74 2562 32 ( ( -LRB- cord-015021-pol2qm74 2562 33 225 225 CD cord-015021-pol2qm74 2562 34 to to IN cord-015021-pol2qm74 2562 35 354 354 CD cord-015021-pol2qm74 2562 36 dyne.sec/cm5 dyne.sec/cm5 NNP cord-015021-pol2qm74 2562 37 ) ) -RRB- cord-015021-pol2qm74 2562 38 , , , cord-015021-pol2qm74 2562 39 cardiac cardiac JJ cord-015021-pol2qm74 2562 40 output output NN cord-015021-pol2qm74 2562 41 decreased decrease VBD cord-015021-pol2qm74 2562 42 ( ( -LRB- cord-015021-pol2qm74 2562 43 17 17 CD cord-015021-pol2qm74 2562 44 to to IN cord-015021-pol2qm74 2562 45 15.2 15.2 CD cord-015021-pol2qm74 2562 46 L l NN cord-015021-pol2qm74 2562 47 / / SYM cord-015021-pol2qm74 2562 48 rain rain NN cord-015021-pol2qm74 2562 49 ) ) -RRB- cord-015021-pol2qm74 2562 50 , , , cord-015021-pol2qm74 2562 51 and and CC cord-015021-pol2qm74 2562 52 cardiac cardiac JJ cord-015021-pol2qm74 2562 53 index index NN cord-015021-pol2qm74 2562 54 declined decline VBD cord-015021-pol2qm74 2562 55 ( ( -LRB- cord-015021-pol2qm74 2562 56 9.94 9.94 CD cord-015021-pol2qm74 2562 57 to to IN cord-015021-pol2qm74 2562 58 8.63 8.63 CD cord-015021-pol2qm74 2562 59 L L NNP cord-015021-pol2qm74 2562 60 / / SYM cord-015021-pol2qm74 2562 61 min min NNP cord-015021-pol2qm74 2562 62 / / SYM cord-015021-pol2qm74 2562 63 m2 m2 NNP cord-015021-pol2qm74 2562 64 } } -RRB- cord-015021-pol2qm74 2562 65 . . . cord-015021-pol2qm74 2563 1 Before before IN cord-015021-pol2qm74 2563 2 and and CC cord-015021-pol2qm74 2563 3 after after IN cord-015021-pol2qm74 2563 4 90 90 CD cord-015021-pol2qm74 2563 5 minutes minute NNS cord-015021-pol2qm74 2563 6 while while IN cord-015021-pol2qm74 2563 7 the the DT cord-015021-pol2qm74 2563 8 infusion infusion NN cord-015021-pol2qm74 2563 9 of of IN cord-015021-pol2qm74 2563 10 L L NNP cord-015021-pol2qm74 2563 11 - - HYPH cord-015021-pol2qm74 2563 12 NMMA NMMA NNP cord-015021-pol2qm74 2563 13 , , , cord-015021-pol2qm74 2563 14 blood blood NN cord-015021-pol2qm74 2563 15 samples sample NNS cord-015021-pol2qm74 2563 16 for for IN cord-015021-pol2qm74 2563 17 immunological immunological JJ cord-015021-pol2qm74 2563 18 measurements measurement NNS cord-015021-pol2qm74 2563 19 were be VBD cord-015021-pol2qm74 2563 20 taken take VBN cord-015021-pol2qm74 2563 21 and and CC cord-015021-pol2qm74 2563 22 processed process VBN cord-015021-pol2qm74 2563 23 together together RB cord-015021-pol2qm74 2563 24 . . . cord-015021-pol2qm74 2564 1 Pulmonary pulmonary JJ cord-015021-pol2qm74 2564 2 - - HYPH cord-015021-pol2qm74 2564 3 shunt shunt NN cord-015021-pol2qm74 2564 4 - - HYPH cord-015021-pol2qm74 2564 5 volume volume NN cord-015021-pol2qm74 2564 6 was be VBD cord-015021-pol2qm74 2564 7 observed observe VBN cord-015021-pol2qm74 2564 8 before before IN cord-015021-pol2qm74 2564 9 the the DT cord-015021-pol2qm74 2564 10 application application NN cord-015021-pol2qm74 2564 11 of of IN cord-015021-pol2qm74 2564 12 L L NNP cord-015021-pol2qm74 2564 13 - - HYPH cord-015021-pol2qm74 2564 14 NMMA NMMA NNP cord-015021-pol2qm74 2564 15 , , , cord-015021-pol2qm74 2564 16 after after IN cord-015021-pol2qm74 2564 17 one one CD cord-015021-pol2qm74 2564 18 hour hour NN cord-015021-pol2qm74 2564 19 and and CC cord-015021-pol2qm74 2564 20 after after IN cord-015021-pol2qm74 2564 21 140 140 CD cord-015021-pol2qm74 2564 22 matutes matute NNS cord-015021-pol2qm74 2564 23 . . . cord-015021-pol2qm74 2565 1 Neopterine Neopterine NNP cord-015021-pol2qm74 2565 2 increased increase VBD cord-015021-pol2qm74 2565 3 from from IN cord-015021-pol2qm74 2565 4 16.51 16.51 CD cord-015021-pol2qm74 2565 5 to to IN cord-015021-pol2qm74 2565 6 32.55 32.55 CD cord-015021-pol2qm74 2565 7 ng ng NN cord-015021-pol2qm74 2565 8 / / SYM cord-015021-pol2qm74 2565 9 ml ml NN cord-015021-pol2qm74 2565 10 , , , cord-015021-pol2qm74 2565 11 tumour tumour NN cord-015021-pol2qm74 2565 12 - - HYPH cord-015021-pol2qm74 2565 13 necrosis necrosis NN cord-015021-pol2qm74 2565 14 - - HYPH cord-015021-pol2qm74 2565 15 factor factor NN cord-015021-pol2qm74 2565 16 - - : cord-015021-pol2qm74 2565 17 a a DT cord-015021-pol2qm74 2565 18 increased increase VBD cord-015021-pol2qm74 2565 19 from from IN cord-015021-pol2qm74 2565 20 24.16 24.16 CD cord-015021-pol2qm74 2565 21 to to IN cord-015021-pol2qm74 2565 22 36.61 36.61 CD cord-015021-pol2qm74 2565 23 pg pg NNS cord-015021-pol2qm74 2565 24 / / SYM cord-015021-pol2qm74 2565 25 ml ml NNP cord-015021-pol2qm74 2565 26 and and CC cord-015021-pol2qm74 2565 27 intedeukin-6 intedeukin-6 NNP cord-015021-pol2qm74 2565 28 increased increase VBD cord-015021-pol2qm74 2565 29 from from IN cord-015021-pol2qm74 2565 30 61.9 61.9 CD cord-015021-pol2qm74 2565 31 to to IN cord-015021-pol2qm74 2565 32 98.2 98.2 CD cord-015021-pol2qm74 2565 33 pg pg NN cord-015021-pol2qm74 2565 34 / / SYM cord-015021-pol2qm74 2565 35 ml ml NN cord-015021-pol2qm74 2565 36 . . . cord-015021-pol2qm74 2566 1 Immunoglobulines Immunoglobulines NNP cord-015021-pol2qm74 2566 2 A A NNP cord-015021-pol2qm74 2566 3 , , , cord-015021-pol2qm74 2566 4 G g NN cord-015021-pol2qm74 2566 5 , , , cord-015021-pol2qm74 2566 6 and and CC cord-015021-pol2qm74 2566 7 M M NNP cord-015021-pol2qm74 2566 8 ( ( -LRB- cord-015021-pol2qm74 2566 9 3.2 3.2 CD cord-015021-pol2qm74 2566 10 to to IN cord-015021-pol2qm74 2566 11 2.9 2.9 CD cord-015021-pol2qm74 2566 12 , , , cord-015021-pol2qm74 2566 13 8.1 8.1 CD cord-015021-pol2qm74 2566 14 to to IN cord-015021-pol2qm74 2566 15 7.6 7.6 CD cord-015021-pol2qm74 2566 16 , , , cord-015021-pol2qm74 2566 17 1.1 1.1 CD cord-015021-pol2qm74 2566 18 to to TO cord-015021-pol2qm74 2566 19 0.9 0.9 CD cord-015021-pol2qm74 2566 20 g g NN cord-015021-pol2qm74 2566 21 / / SYM cord-015021-pol2qm74 2566 22 I i NN cord-015021-pol2qm74 2566 23 ) ) -RRB- cord-015021-pol2qm74 2566 24 , , , cord-015021-pol2qm74 2566 25 Complement Complement NNP cord-015021-pol2qm74 2566 26 factor factor NN cord-015021-pol2qm74 2566 27 C-3c c-3c NN cord-015021-pol2qm74 2566 28 and and CC cord-015021-pol2qm74 2566 29 C-4 C-4 NNP cord-015021-pol2qm74 2566 30 ( ( -LRB- cord-015021-pol2qm74 2566 31 0.54 0.54 CD cord-015021-pol2qm74 2566 32 to to IN cord-015021-pol2qm74 2566 33 0.50 0.50 CD cord-015021-pol2qm74 2566 34 , , , cord-015021-pol2qm74 2566 35 0.22 0.22 CD cord-015021-pol2qm74 2566 36 to to IN cord-015021-pol2qm74 2566 37 0.23 0.23 CD cord-015021-pol2qm74 2566 38 g g NN cord-015021-pol2qm74 2566 39 / / SYM cord-015021-pol2qm74 2566 40 I i NN cord-015021-pol2qm74 2566 41 ) ) -RRB- cord-015021-pol2qm74 2566 42 , , , cord-015021-pol2qm74 2566 43 alpha alpha NN cord-015021-pol2qm74 2566 44 - - HYPH cord-015021-pol2qm74 2566 45 l l NN cord-015021-pol2qm74 2566 46 - - HYPH cord-015021-pol2qm74 2566 47 antitrypsine antitrypsine NNP cord-015021-pol2qm74 2566 48 ( ( -LRB- cord-015021-pol2qm74 2566 49 3.86 3.86 CD cord-015021-pol2qm74 2566 50 to to TO cord-015021-pol2qm74 2566 51 3.83 3.83 CD cord-015021-pol2qm74 2566 52 g g NN cord-015021-pol2qm74 2566 53 / / SYM cord-015021-pol2qm74 2566 54 I i NN cord-015021-pol2qm74 2566 55 ) ) -RRB- cord-015021-pol2qm74 2566 56 , , , cord-015021-pol2qm74 2566 57 C c NN cord-015021-pol2qm74 2566 58 - - HYPH cord-015021-pol2qm74 2566 59 reactive reactive JJ cord-015021-pol2qm74 2566 60 - - HYPH cord-015021-pol2qm74 2566 61 protein protein NN cord-015021-pol2qm74 2566 62 ( ( -LRB- cord-015021-pol2qm74 2566 63 111.1 111.1 CD cord-015021-pol2qm74 2566 64 to to IN cord-015021-pol2qm74 2566 65 105.6 105.6 CD cord-015021-pol2qm74 2566 66 rag rag NN cord-015021-pol2qm74 2566 67 / / , cord-015021-pol2qm74 2566 68 I i NN cord-015021-pol2qm74 2566 69 ) ) -RRB- cord-015021-pol2qm74 2566 70 , , , cord-015021-pol2qm74 2566 71 interleukin-1 interleukin-1 NN cord-015021-pol2qm74 2566 72 ( ( -LRB- cord-015021-pol2qm74 2566 73 0 0 CD cord-015021-pol2qm74 2566 74 pg pg NN cord-015021-pol2qm74 2566 75 / / SYM cord-015021-pol2qm74 2566 76 ml ml NN cord-015021-pol2qm74 2566 77 ) ) -RRB- cord-015021-pol2qm74 2566 78 and and CC cord-015021-pol2qm74 2566 79 soluble soluble JJ cord-015021-pol2qm74 2566 80 interleukin-2 interleukin-2 IN cord-015021-pol2qm74 2566 81 ( ( -LRB- cord-015021-pol2qm74 2566 82 2128 2128 CD cord-015021-pol2qm74 2566 83 to to IN cord-015021-pol2qm74 2566 84 1983 1983 CD cord-015021-pol2qm74 2566 85 Units Units NNP cord-015021-pol2qm74 2566 86 / / SYM cord-015021-pol2qm74 2566 87 ml ml NN cord-015021-pol2qm74 2566 88 ) ) -RRB- cord-015021-pol2qm74 2566 89 did do VBD cord-015021-pol2qm74 2566 90 not not RB cord-015021-pol2qm74 2566 91 change change VB cord-015021-pol2qm74 2566 92 significantly significantly RB cord-015021-pol2qm74 2566 93 . . . cord-015021-pol2qm74 2567 1 Pulmonary Pulmonary NNP cord-015021-pol2qm74 2567 2 - - HYPH cord-015021-pol2qm74 2567 3 shuntvolume shuntvolume NN cord-015021-pol2qm74 2567 4 decreased decrease VBD cord-015021-pol2qm74 2567 5 from from IN cord-015021-pol2qm74 2567 6 54.1 54.1 CD cord-015021-pol2qm74 2567 7 % % NN cord-015021-pol2qm74 2567 8 to to IN cord-015021-pol2qm74 2567 9 35.4 35.4 CD cord-015021-pol2qm74 2567 10 % % NN cord-015021-pol2qm74 2567 11 within within IN cord-015021-pol2qm74 2567 12 one one CD cord-015021-pol2qm74 2567 13 hour hour NN cord-015021-pol2qm74 2567 14 and and CC cord-015021-pol2qm74 2567 15 to to IN cord-015021-pol2qm74 2567 16 36.6 36.6 CD cord-015021-pol2qm74 2567 17 % % NN cord-015021-pol2qm74 2567 18 after after IN cord-015021-pol2qm74 2567 19 140 140 CD cord-015021-pol2qm74 2567 20 minutes minute NNS cord-015021-pol2qm74 2567 21 . . . cord-015021-pol2qm74 2568 1 In in IN cord-015021-pol2qm74 2568 2 septic septic JJ cord-015021-pol2qm74 2568 3 shock shock NN cord-015021-pol2qm74 2568 4 blocking block VBG cord-015021-pol2qm74 2568 5 nitric nitric NN cord-015021-pol2qm74 2568 6 oxide oxide NN cord-015021-pol2qm74 2568 7 as as IN cord-015021-pol2qm74 2568 8 an an DT cord-015021-pol2qm74 2568 9 intervention intervention NN cord-015021-pol2qm74 2568 10 at at IN cord-015021-pol2qm74 2568 11 the the DT cord-015021-pol2qm74 2568 12 end end NN cord-015021-pol2qm74 2568 13 of of IN cord-015021-pol2qm74 2568 14 a a DT cord-015021-pol2qm74 2568 15 not not RB cord-015021-pol2qm74 2568 16 ~,et ~,et JJ cord-015021-pol2qm74 2569 1 ful!y ful!y NNP cord-015021-pol2qm74 2569 2 understood understand VBD cord-015021-pol2qm74 2569 3 cascade cascade NN cord-015021-pol2qm74 2569 4 might may MD cord-015021-pol2qm74 2569 5 have have VB cord-015021-pol2qm74 2569 6 important important JJ cord-015021-pol2qm74 2569 7 influences influence NNS cord-015021-pol2qm74 2569 8 on on IN cord-015021-pol2qm74 2569 9 pulmonary pulmonary JJ cord-015021-pol2qm74 2569 10 - - HYPH cord-015021-pol2qm74 2569 11 shunt shunt NN cord-015021-pol2qm74 2569 12 - - HYPH cord-015021-pol2qm74 2569 13 volume volume NN cord-015021-pol2qm74 2569 14 and and CC cord-015021-pol2qm74 2569 15 inter inter JJ cord-015021-pol2qm74 2569 16 - - JJ cord-015021-pol2qm74 2569 17 cell cell NN cord-015021-pol2qm74 2569 18 - - HYPH cord-015021-pol2qm74 2569 19 communication communication NN cord-015021-pol2qm74 2569 20 . . . cord-015021-pol2qm74 2570 1 Department Department NNP cord-015021-pol2qm74 2570 2 of of IN cord-015021-pol2qm74 2570 3 Surgery Surgery NNP cord-015021-pol2qm74 2570 4 , , , cord-015021-pol2qm74 2570 5 Pharmacy Pharmacy NNP cord-015021-pol2qm74 2570 6 * * NFP cord-015021-pol2qm74 2570 7 and and CC cord-015021-pol2qm74 2570 8 Immunology Immunology NNP cord-015021-pol2qm74 2571 1 * * NFP cord-015021-pol2qm74 2571 2 * * NFP cord-015021-pol2qm74 2571 3 , , , cord-015021-pol2qm74 2571 4 University University NNP cord-015021-pol2qm74 2571 5 Hospital Hospital NNP cord-015021-pol2qm74 2571 6 of of IN cord-015021-pol2qm74 2571 7 Zurich Zurich NNP cord-015021-pol2qm74 2571 8 , , , cord-015021-pol2qm74 2572 1 R R NNP cord-015021-pol2qm74 2572 2 ~ ~ CD cord-015021-pol2qm74 2572 3 imistrasse imistrasse NNP cord-015021-pol2qm74 2572 4 100 100 CD cord-015021-pol2qm74 2572 5 , , , cord-015021-pol2qm74 2572 6 8091 8091 CD cord-015021-pol2qm74 2572 7 Zurich Zurich NNP cord-015021-pol2qm74 2572 8 , , , cord-015021-pol2qm74 2572 9 Switzerland Switzerland NNP cord-015021-pol2qm74 2573 1 We -PRON- PRP cord-015021-pol2qm74 2573 2 previously previously RB cord-015021-pol2qm74 2573 3 reported report VBD cord-015021-pol2qm74 2573 4 that that IN cord-015021-pol2qm74 2573 5 hypoferremic hypoferremic NN cord-015021-pol2qm74 2573 6 CBA CBA NNP cord-015021-pol2qm74 2573 7 mice mouse NNS cord-015021-pol2qm74 2573 8 had have VBD cord-015021-pol2qm74 2573 9 an an DT cord-015021-pol2qm74 2573 10 increased increase VBN cord-015021-pol2qm74 2573 11 resistance resistance NN cord-015021-pol2qm74 2573 12 to to IN cord-015021-pol2qm74 2573 13 Salmonella salmonella NN cord-015021-pol2qm74 2573 14 infection infection NN cord-015021-pol2qm74 2573 15 , , , cord-015021-pol2qm74 2573 16 and and CC cord-015021-pol2qm74 2573 17 that that DT cord-015021-pol2qm74 2573 18 injection injection NN cord-015021-pol2qm74 2573 19 of of IN cord-015021-pol2qm74 2573 20 Ammonium Ammonium NNP cord-015021-pol2qm74 2573 21 Ferric Ferric NNP cord-015021-pol2qm74 2573 22 Citrate Citrate NNP cord-015021-pol2qm74 2573 23 ( ( -LRB- cord-015021-pol2qm74 2573 24 AFC AFC NNP cord-015021-pol2qm74 2573 25 ) ) -RRB- cord-015021-pol2qm74 2573 26 to to IN cord-015021-pol2qm74 2573 27 these these DT cord-015021-pol2qm74 2573 28 mice mouse NNS cord-015021-pol2qm74 2573 29 led lead VBD cord-015021-pol2qm74 2573 30 to to IN cord-015021-pol2qm74 2573 31 enhanced enhance VBN cord-015021-pol2qm74 2573 32 infection infection NN cord-015021-pol2qm74 2573 33 ( ( -LRB- cord-015021-pol2qm74 2573 34 Ganthier Ganthier NNP cord-015021-pol2qm74 2573 35 et et NNP cord-015021-pol2qm74 2573 36 at at IN cord-015021-pol2qm74 2573 37 . . . cord-015021-pol2qm74 2573 38 1986 1986 CD cord-015021-pol2qm74 2573 39 . . . cord-015021-pol2qm74 2574 1 Microbiol Microbiol NNP cord-015021-pol2qm74 2574 2 . . . cord-015021-pol2qm74 2575 1 Immuno130:425 Immuno130:425 NNP cord-015021-pol2qm74 2575 2 ) ) -RRB- cord-015021-pol2qm74 2575 3 . . . cord-015021-pol2qm74 2576 1 Because because IN cord-015021-pol2qm74 2576 2 Nitric nitric NN cord-015021-pol2qm74 2576 3 Oxide Oxide NNP cord-015021-pol2qm74 2576 4 ( ( -LRB- cord-015021-pol2qm74 2576 5 NO no UH cord-015021-pol2qm74 2576 6 ) ) -RRB- cord-015021-pol2qm74 2576 7 is be VBZ cord-015021-pol2qm74 2576 8 involved involve VBN cord-015021-pol2qm74 2576 9 in in IN cord-015021-pol2qm74 2576 10 the the DT cord-015021-pol2qm74 2576 11 antimicrobial antimicrobial JJ cord-015021-pol2qm74 2576 12 activity activity NN cord-015021-pol2qm74 2576 13 of of IN cord-015021-pol2qm74 2576 14 routine routine JJ cord-015021-pol2qm74 2576 15 macmphages macmphage NNS cord-015021-pol2qm74 2576 16 towards towards IN cord-015021-pol2qm74 2576 17 various various JJ cord-015021-pol2qm74 2576 18 inttacellular inttacellular JJ cord-015021-pol2qm74 2576 19 pathogens pathogen NNS cord-015021-pol2qm74 2576 20 , , , cord-015021-pol2qm74 2576 21 we -PRON- PRP cord-015021-pol2qm74 2576 22 investigated investigate VBD cord-015021-pol2qm74 2576 23 the the DT cord-015021-pol2qm74 2576 24 influence influence NN cord-015021-pol2qm74 2576 25 of of IN cord-015021-pol2qm74 2576 26 iron iron NN cord-015021-pol2qm74 2576 27 on on IN cord-015021-pol2qm74 2576 28 the the DT cord-015021-pol2qm74 2576 29 bactericidal bactericidal JJ cord-015021-pol2qm74 2576 30 activity activity NN cord-015021-pol2qm74 2576 31 of of IN cord-015021-pol2qm74 2576 32 CBA CBA NNP cord-015021-pol2qm74 2576 33 mouse mouse NN cord-015021-pol2qm74 2576 34 macrophages macrophage NNS cord-015021-pol2qm74 2576 35 towards towards IN cord-015021-pol2qm74 2576 36 S.typhimurium s.typhimurium NN cord-015021-pol2qm74 2576 37 and and CC cord-015021-pol2qm74 2576 38 on on IN cord-015021-pol2qm74 2576 39 the the DT cord-015021-pol2qm74 2576 40 production production NN cord-015021-pol2qm74 2576 41 and and CC cord-015021-pol2qm74 2576 42 activity activity NN cord-015021-pol2qm74 2576 43 of of IN cord-015021-pol2qm74 2576 44 Reactive Reactive NNP cord-015021-pol2qm74 2576 45 Nitrogen Nitrogen NNP cord-015021-pol2qm74 2576 46 Intermediates Intermediates NNPS cord-015021-pol2qm74 2576 47 ( ( -LRB- cord-015021-pol2qm74 2576 48 RNI RNI NNP cord-015021-pol2qm74 2576 49 ) ) -RRB- cord-015021-pol2qm74 2576 50 . . . cord-015021-pol2qm74 2577 1 Peritoneal peritoneal JJ cord-015021-pol2qm74 2577 2 macrophages macrophage NNS cord-015021-pol2qm74 2577 3 hum hum VBP cord-015021-pol2qm74 2577 4 CBA CBA NNP cord-015021-pol2qm74 2577 5 mice mouse NNS cord-015021-pol2qm74 2577 6 were be VBD cord-015021-pol2qm74 2577 7 cultured culture VBN cord-015021-pol2qm74 2577 8 in in IN cord-015021-pol2qm74 2577 9 the the DT cord-015021-pol2qm74 2577 10 presence presence NN cord-015021-pol2qm74 2577 11 ( ( -LRB- cord-015021-pol2qm74 2577 12 or or CC cord-015021-pol2qm74 2577 13 not not RB cord-015021-pol2qm74 2577 14 ) ) -RRB- cord-015021-pol2qm74 2577 15 of of IN cord-015021-pol2qm74 2577 16 AFC AFC NNP cord-015021-pol2qm74 2577 17 50 50 CD cord-015021-pol2qm74 2577 18 , , , cord-015021-pol2qm74 2577 19 uM um UH cord-015021-pol2qm74 2577 20 , , , cord-015021-pol2qm74 2577 21 IFN-,/250 IFN-,/250 NNP cord-015021-pol2qm74 2577 22 U U NNP cord-015021-pol2qm74 2577 23 / / SYM cord-015021-pol2qm74 2577 24 ml ml XX cord-015021-pol2qm74 2577 25 , , , cord-015021-pol2qm74 2577 26 LPS LPS NNP cord-015021-pol2qm74 2577 27 1 1 CD cord-015021-pol2qm74 2577 28 fig fig NN cord-015021-pol2qm74 2577 29 / / SYM cord-015021-pol2qm74 2577 30 m/ m/ JJ cord-015021-pol2qm74 2577 31 , , , cord-015021-pol2qm74 2577 32 NGMonomethyl NGMonomethyl NNP cord-015021-pol2qm74 2577 33 - - HYPH cord-015021-pol2qm74 2577 34 L l NN cord-015021-pol2qm74 2577 35 -- -- : cord-015021-pol2qm74 2577 36 Arginine arginine NN cord-015021-pol2qm74 2577 37 ( ( -LRB- cord-015021-pol2qm74 2577 38 MMLA MMLA NNP cord-015021-pol2qm74 2577 39 ) ) -RRB- cord-015021-pol2qm74 2578 1 2raM. 2ram. CD cord-015021-pol2qm74 2579 1 Nitrite nitrite NN cord-015021-pol2qm74 2579 2 ( ( -LRB- cord-015021-pol2qm74 2579 3 NO2- NO2- NNP cord-015021-pol2qm74 2579 4 ) ) -RRB- cord-015021-pol2qm74 2579 5 content content NN cord-015021-pol2qm74 2579 6 of of IN cord-015021-pol2qm74 2579 7 the the DT cord-015021-pol2qm74 2579 8 supematants supematant NNS cord-015021-pol2qm74 2579 9 was be VBD cord-015021-pol2qm74 2579 10 determined determine VBN cord-015021-pol2qm74 2579 11 by by IN cord-015021-pol2qm74 2579 12 a a DT cord-015021-pol2qm74 2579 13 standard standard JJ cord-015021-pol2qm74 2579 14 Griess Griess NNP cord-015021-pol2qm74 2579 15 reaction reaction NN cord-015021-pol2qm74 2579 16 , , , cord-015021-pol2qm74 2579 17 and and CC cord-015021-pol2qm74 2579 18 H202 h202 NN cord-015021-pol2qm74 2579 19 release release NN cord-015021-pol2qm74 2579 20 was be VBD cord-015021-pol2qm74 2579 21 measured measure VBN cord-015021-pol2qm74 2579 22 by by IN cord-015021-pol2qm74 2579 23 the the DT cord-015021-pol2qm74 2579 24 peroxidese peroxidese JJ cord-015021-pol2qm74 2579 25 dependant dependant JJ cord-015021-pol2qm74 2579 26 oxidation oxidation NN cord-015021-pol2qm74 2579 27 of of IN cord-015021-pol2qm74 2579 28 phenol phenol NN cord-015021-pol2qm74 2579 29 red red NN cord-015021-pol2qm74 2579 30 . . . cord-015021-pol2qm74 2580 1 For for IN cord-015021-pol2qm74 2580 2 intracellular intracellular JJ cord-015021-pol2qm74 2580 3 killing killing NN cord-015021-pol2qm74 2580 4 , , , cord-015021-pol2qm74 2580 5 macrophages macrophages NN cord-015021-pol2qm74 2580 6 monolayers monolayer NNS cord-015021-pol2qm74 2580 7 were be VBD cord-015021-pol2qm74 2580 8 infected infect VBN cord-015021-pol2qm74 2580 9 , , , cord-015021-pol2qm74 2580 10 and and CC cord-015021-pol2qm74 2580 11 , , , cord-015021-pol2qm74 2580 12 at at IN cord-015021-pol2qm74 2580 13 various various JJ cord-015021-pol2qm74 2580 14 intervals interval NNS cord-015021-pol2qm74 2580 15 , , , cord-015021-pol2qm74 2580 16 lysed lyse VBN cord-015021-pol2qm74 2580 17 by by IN cord-015021-pol2qm74 2580 18 Triton Triton NNP cord-015021-pol2qm74 2580 19 X-100 x-100 NN cord-015021-pol2qm74 2580 20 , , , cord-015021-pol2qm74 2580 21 and and CC cord-015021-pol2qm74 2580 22 surviving survive VBG cord-015021-pol2qm74 2580 23 bacteria bacteria NNS cord-015021-pol2qm74 2580 24 enumerated enumerate VBN cord-015021-pol2qm74 2580 25 by by IN cord-015021-pol2qm74 2580 26 colony colony NN cord-015021-pol2qm74 2580 27 counting counting NN cord-015021-pol2qm74 2580 28 on on IN cord-015021-pol2qm74 2580 29 agar agar NN cord-015021-pol2qm74 2580 30 . . . cord-015021-pol2qm74 2581 1 For for IN cord-015021-pol2qm74 2581 2 in in IN cord-015021-pol2qm74 2581 3 vivo vivo NN cord-015021-pol2qm74 2581 4 experiments experiment NNS cord-015021-pol2qm74 2581 5 , , , cord-015021-pol2qm74 2581 6 mice mouse NNS cord-015021-pol2qm74 2581 7 were be VBD cord-015021-pol2qm74 2581 8 infected infect VBN cord-015021-pol2qm74 2581 9 IP ip NN cord-015021-pol2qm74 2581 10 with with IN cord-015021-pol2qm74 2581 11 0.5 0.5 CD cord-015021-pol2qm74 2581 12 ml ml NNS cord-015021-pol2qm74 2581 13 of of IN cord-015021-pol2qm74 2581 14 a a DT cord-015021-pol2qm74 2581 15 suspension suspension NN cord-015021-pol2qm74 2581 16 of of IN cord-015021-pol2qm74 2581 17 5.10 5.10 CD cord-015021-pol2qm74 2581 18 ~ ~ NFP cord-015021-pol2qm74 2581 19 " " '' cord-015021-pol2qm74 2581 20 S.typhimurium s.typhimurium NN cord-015021-pol2qm74 2581 21 , , , cord-015021-pol2qm74 2581 22 strain strain VB cord-015021-pol2qm74 2581 23 C5 c5 NN cord-015021-pol2qm74 2581 24 , , , cord-015021-pol2qm74 2581 25 and and CC cord-015021-pol2qm74 2581 26 injected inject VBN cord-015021-pol2qm74 2581 27 with with IN cord-015021-pol2qm74 2581 28 Aminoguanidine Aminoguanidine NNP cord-015021-pol2qm74 2581 29 ( ( -LRB- cord-015021-pol2qm74 2581 30 AG AG NNP cord-015021-pol2qm74 2581 31 ) ) -RRB- cord-015021-pol2qm74 2581 32 1 1 CD cord-015021-pol2qm74 2581 33 mg mg NNP cord-015021-pol2qm74 2581 34 / / SYM cord-015021-pol2qm74 2581 35 ml ml NN cord-015021-pol2qm74 2581 36 in in IN cord-015021-pol2qm74 2581 37 saline saline NN cord-015021-pol2qm74 2581 38 . . . cord-015021-pol2qm74 2582 1 Our -PRON- PRP$ cord-015021-pol2qm74 2582 2 results result NNS cord-015021-pol2qm74 2582 3 show show VBP cord-015021-pol2qm74 2582 4 that that IN cord-015021-pol2qm74 2582 5 the the DT cord-015021-pol2qm74 2582 6 RN rn NN cord-015021-pol2qm74 2582 7 [ [ -LRB- cord-015021-pol2qm74 2582 8 inhibitor inhibitor NN cord-015021-pol2qm74 2582 9 AG AG NNP cord-015021-pol2qm74 2582 10 strongly strongly RB cord-015021-pol2qm74 2582 11 accelerates accelerate VBZ cord-015021-pol2qm74 2582 12 the the DT cord-015021-pol2qm74 2582 13 mortality mortality NN cord-015021-pol2qm74 2582 14 of of IN cord-015021-pol2qm74 2582 15 infected infected JJ cord-015021-pol2qm74 2582 16 mice mouse NNS cord-015021-pol2qm74 2582 17 , , , cord-015021-pol2qm74 2582 18 the the DT cord-015021-pol2qm74 2582 19 survival survival NN cord-015021-pol2qm74 2582 20 rate rate NN cord-015021-pol2qm74 2582 21 decreasing decrease VBG cord-015021-pol2qm74 2582 22 from from IN cord-015021-pol2qm74 2582 23 60 60 CD cord-015021-pol2qm74 2582 24 % % NN cord-015021-pol2qm74 2582 25 in in IN cord-015021-pol2qm74 2582 26 the the DT cord-015021-pol2qm74 2582 27 control control NN cord-015021-pol2qm74 2582 28 group group NN cord-015021-pol2qm74 2582 29 to to IN cord-015021-pol2qm74 2582 30 20 20 CD cord-015021-pol2qm74 2582 31 % % NN cord-015021-pol2qm74 2582 32 in in IN cord-015021-pol2qm74 2582 33 the the DT cord-015021-pol2qm74 2582 34 treated treated JJ cord-015021-pol2qm74 2582 35 group group NN cord-015021-pol2qm74 2582 36 , , , cord-015021-pol2qm74 2582 37 10 10 CD cord-015021-pol2qm74 2582 38 days day NNS cord-015021-pol2qm74 2582 39 after after IN cord-015021-pol2qm74 2582 40 challenge challenge NN cord-015021-pol2qm74 2582 41 . . . cord-015021-pol2qm74 2583 1 Correlatively correlatively RB cord-015021-pol2qm74 2583 2 the the DT cord-015021-pol2qm74 2583 3 RNI RNI NNP cord-015021-pol2qm74 2583 4 inhibitor inhibitor NN cord-015021-pol2qm74 2583 5 MMLA MMLA NNP cord-015021-pol2qm74 2583 6 induces induce VBZ cord-015021-pol2qm74 2583 7 in in IN cord-015021-pol2qm74 2583 8 vitro vitro FW cord-015021-pol2qm74 2583 9 a a DT cord-015021-pol2qm74 2583 10 decrease decrease NN cord-015021-pol2qm74 2583 11 in in IN cord-015021-pol2qm74 2583 12 the the DT cord-015021-pol2qm74 2583 13 rate rate NN cord-015021-pol2qm74 2583 14 of of IN cord-015021-pol2qm74 2583 15 bacterial bacterial JJ cord-015021-pol2qm74 2583 16 killing killing NN cord-015021-pol2qm74 2583 17 , , , cord-015021-pol2qm74 2583 18 fxom fxom NNP cord-015021-pol2qm74 2583 19 78 78 CD cord-015021-pol2qm74 2583 20 % % NN cord-015021-pol2qm74 2583 21 to to IN cord-015021-pol2qm74 2583 22 57 57 CD cord-015021-pol2qm74 2583 23 % % NN cord-015021-pol2qm74 2583 24 , , , cord-015021-pol2qm74 2583 25 in in IN cord-015021-pol2qm74 2583 26 macrophages macrophage NNS cord-015021-pol2qm74 2583 27 triggered trigger VBN cord-015021-pol2qm74 2583 28 with with IN cord-015021-pol2qm74 2583 29 IFN- IFN- NNP cord-015021-pol2qm74 2583 30 ? ? . cord-015021-pol2qm74 2583 31 + + NFP cord-015021-pol2qm74 2583 32 LPS lp NNS cord-015021-pol2qm74 2583 33 . . . cord-015021-pol2qm74 2584 1 The the DT cord-015021-pol2qm74 2584 2 cultivation cultivation NN cord-015021-pol2qm74 2584 3 of of IN cord-015021-pol2qm74 2584 4 macrophages macrophage NNS cord-015021-pol2qm74 2584 5 in in IN cord-015021-pol2qm74 2584 6 the the DT cord-015021-pol2qm74 2584 7 presence presence NN cord-015021-pol2qm74 2584 8 of of IN cord-015021-pol2qm74 2584 9 AFC AFC NNP cord-015021-pol2qm74 2584 10 leads lead VBZ cord-015021-pol2qm74 2584 11 to to IN cord-015021-pol2qm74 2584 12 a a DT cord-015021-pol2qm74 2584 13 decreased decrease VBN cord-015021-pol2qm74 2584 14 NO no DT cord-015021-pol2qm74 2584 15 2-accumulation 2-accumulation CD cord-015021-pol2qm74 2584 16 , , , cord-015021-pol2qm74 2584 17 4.7 4.7 CD cord-015021-pol2qm74 2584 18 nmole nmole NNP cord-015021-pol2qm74 2584 19 / / SYM cord-015021-pol2qm74 2584 20 well well RB cord-015021-pol2qm74 2584 21 v.s. v.s. NNP cord-015021-pol2qm74 2584 22 21 21 CD cord-015021-pol2qm74 2584 23 nmole/ nmole/ ADD cord-015021-pol2qm74 2585 1 well well UH cord-015021-pol2qm74 2585 2 . . . cord-015021-pol2qm74 2586 1 Conversely conversely RB cord-015021-pol2qm74 2586 2 H202 h202 NN cord-015021-pol2qm74 2586 3 production production NN cord-015021-pol2qm74 2586 4 is be VBZ cord-015021-pol2qm74 2586 5 enhanced enhance VBN cord-015021-pol2qm74 2586 6 from from IN cord-015021-pol2qm74 2586 7 09 09 CD cord-015021-pol2qm74 2586 8 nmole/ nmole/ ADD cord-015021-pol2qm74 2587 1 well well UH cord-015021-pol2qm74 2587 2 up up IN cord-015021-pol2qm74 2587 3 to to IN cord-015021-pol2qm74 2587 4 2,33 2,33 CD cord-015021-pol2qm74 2587 5 nmole/ nmole/ ADD cord-015021-pol2qm74 2588 1 well well UH cord-015021-pol2qm74 2588 2 . . . cord-015021-pol2qm74 2589 1 Nevertheless nevertheless RB cord-015021-pol2qm74 2589 2 , , , cord-015021-pol2qm74 2589 3 macrophages macrophage NNS cord-015021-pol2qm74 2589 4 cultivated cultivate VBN cord-015021-pol2qm74 2589 5 in in IN cord-015021-pol2qm74 2589 6 the the DT cord-015021-pol2qm74 2589 7 presence presence NN cord-015021-pol2qm74 2589 8 of of IN cord-015021-pol2qm74 2589 9 AFC AFC NNP cord-015021-pol2qm74 2589 10 exhibit exhibit VB cord-015021-pol2qm74 2589 11 an an DT cord-015021-pol2qm74 2589 12 increased increase VBN cord-015021-pol2qm74 2589 13 tale tale NN cord-015021-pol2qm74 2589 14 of of IN cord-015021-pol2qm74 2589 15 intracellular intracellular JJ cord-015021-pol2qm74 2589 16 killing killing NN cord-015021-pol2qm74 2589 17 , , , cord-015021-pol2qm74 2589 18 77 77 CD cord-015021-pol2qm74 2589 19 % % NN cord-015021-pol2qm74 2589 20 in in IN cord-015021-pol2qm74 2589 21 iron iron NN cord-015021-pol2qm74 2589 22 exposed expose VBN cord-015021-pol2qm74 2589 23 macrophages macrophage NNS cord-015021-pol2qm74 2589 24 v.s v.s NNP cord-015021-pol2qm74 2589 25 , , , cord-015021-pol2qm74 2589 26 68 68 CD cord-015021-pol2qm74 2589 27 % % NN cord-015021-pol2qm74 2589 28 in in IN cord-015021-pol2qm74 2589 29 control control NN cord-015021-pol2qm74 2589 30 macrophages macrophage NNS cord-015021-pol2qm74 2589 31 . . . cord-015021-pol2qm74 2590 1 When when WRB cord-015021-pol2qm74 2590 2 triggered trigger VBN cord-015021-pol2qm74 2590 3 with with IN cord-015021-pol2qm74 2590 4 IFN-~ IFN-~ NNP cord-015021-pol2qm74 2590 5 , , , cord-015021-pol2qm74 2590 6 alone alone RB cord-015021-pol2qm74 2590 7 , , , cord-015021-pol2qm74 2590 8 macrophages macrophage NNS cord-015021-pol2qm74 2590 9 have have VBP cord-015021-pol2qm74 2590 10 a a DT cord-015021-pol2qm74 2590 11 reduced reduce VBN cord-015021-pol2qm74 2590 12 antibacterial antibacterial JJ cord-015021-pol2qm74 2590 13 activity activity NN cord-015021-pol2qm74 2590 14 ( ( -LRB- cord-015021-pol2qm74 2590 15 57 57 CD cord-015021-pol2qm74 2590 16 % % NN cord-015021-pol2qm74 2590 17 v.s. v.s. NNP cord-015021-pol2qm74 2590 18 68 68 CD cord-015021-pol2qm74 2590 19 % % NN cord-015021-pol2qm74 2590 20 ) ) -RRB- cord-015021-pol2qm74 2590 21 whereas whereas IN cord-015021-pol2qm74 2590 22 the the DT cord-015021-pol2qm74 2590 23 addition addition NN cord-015021-pol2qm74 2590 24 of of IN cord-015021-pol2qm74 2590 25 AFC AFC NNP cord-015021-pol2qm74 2590 26 to to IN cord-015021-pol2qm74 2590 27 these these DT cord-015021-pol2qm74 2590 28 macrophagas macrophagas NN cord-015021-pol2qm74 2590 29 restores restore VBZ cord-015021-pol2qm74 2590 30 an an DT cord-015021-pol2qm74 2590 31 elevated elevated JJ cord-015021-pol2qm74 2590 32 ( ( -LRB- cord-015021-pol2qm74 2590 33 72 72 CD cord-015021-pol2qm74 2590 34 % % NN cord-015021-pol2qm74 2590 35 ) ) -RRB- cord-015021-pol2qm74 2590 36 rate rate NN cord-015021-pol2qm74 2590 37 of of IN cord-015021-pol2qm74 2590 38 killing killing NN cord-015021-pol2qm74 2590 39 . . . cord-015021-pol2qm74 2591 1 In in IN cord-015021-pol2qm74 2591 2 conclusion conclusion NN cord-015021-pol2qm74 2591 3 , , , cord-015021-pol2qm74 2591 4 the the DT cord-015021-pol2qm74 2591 5 results result NNS cord-015021-pol2qm74 2591 6 show show VBP cord-015021-pol2qm74 2591 7 that that IN cord-015021-pol2qm74 2591 8 bactericidal bactericidal JJ cord-015021-pol2qm74 2591 9 activity activity NN cord-015021-pol2qm74 2591 10 of of IN cord-015021-pol2qm74 2591 11 CBA CBA NNP cord-015021-pol2qm74 2591 12 macrophages macrophage NNS cord-015021-pol2qm74 2591 13 towards towards IN cord-015021-pol2qm74 2591 14 S.typhimurium s.typhimurium NN cord-015021-pol2qm74 2591 15 depends depend VBZ cord-015021-pol2qm74 2591 16 on on IN cord-015021-pol2qm74 2591 17 the the DT cord-015021-pol2qm74 2591 18 production production NN cord-015021-pol2qm74 2591 19 of of IN cord-015021-pol2qm74 2591 20 NO no NN cord-015021-pol2qm74 2591 21 by by IN cord-015021-pol2qm74 2591 22 these these DT cord-015021-pol2qm74 2591 23 macrophages macrophage NNS cord-015021-pol2qm74 2591 24 ; ; : cord-015021-pol2qm74 2591 25 but but CC cord-015021-pol2qm74 2591 26 they -PRON- PRP cord-015021-pol2qm74 2591 27 also also RB cord-015021-pol2qm74 2591 28 demonstrate demonstrate VBP cord-015021-pol2qm74 2591 29 that that IN cord-015021-pol2qm74 2591 30 NO no NN cord-015021-pol2qm74 2591 31 is be VBZ cord-015021-pol2qm74 2591 32 not not RB cord-015021-pol2qm74 2591 33 the the DT cord-015021-pol2qm74 2591 34 only only JJ cord-015021-pol2qm74 2591 35 reactive reactive JJ cord-015021-pol2qm74 2591 36 species specie NNS cord-015021-pol2qm74 2591 37 involved involve VBN cord-015021-pol2qm74 2591 38 in in IN cord-015021-pol2qm74 2591 39 the the DT cord-015021-pol2qm74 2591 40 intracellular intracellular JJ cord-015021-pol2qm74 2591 41 kil kil NN cord-015021-pol2qm74 2591 42 / / SYM cord-015021-pol2qm74 2591 43 ing ing NN cord-015021-pol2qm74 2591 44 of of IN cord-015021-pol2qm74 2591 45 S.thyphimurium s.thyphimurium NN cord-015021-pol2qm74 2591 46 ; ; : cord-015021-pol2qm74 2591 47 indeed indeed RB cord-015021-pol2qm74 2591 48 AFC AFC NNP cord-015021-pol2qm74 2591 49 which which WDT cord-015021-pol2qm74 2591 50 strongly strongly RB cord-015021-pol2qm74 2591 51 inhibits inhibit VBZ cord-015021-pol2qm74 2591 52 RNI RNI NNP cord-015021-pol2qm74 2591 53 production production NN cord-015021-pol2qm74 2591 54 , , , cord-015021-pol2qm74 2591 55 stimulates stimulate VBZ cord-015021-pol2qm74 2591 56 H20 H20 NNP cord-015021-pol2qm74 2591 57 2 2 CD cord-015021-pol2qm74 2591 58 release release NN cord-015021-pol2qm74 2591 59 by by IN cord-015021-pol2qm74 2591 60 these these DT cord-015021-pol2qm74 2591 61 macrophages macrophage NNS cord-015021-pol2qm74 2591 62 and and CC cord-015021-pol2qm74 2591 63 increase increase VB cord-015021-pol2qm74 2591 64 their -PRON- PRP$ cord-015021-pol2qm74 2591 65 bactericidal bactericidal JJ cord-015021-pol2qm74 2591 66 activity activity NN cord-015021-pol2qm74 2591 67 in in IN cord-015021-pol2qm74 2591 68 vitro vitro FW cord-015021-pol2qm74 2591 69 . . . cord-015021-pol2qm74 2592 1 Nevertheless nevertheless RB cord-015021-pol2qm74 2592 2 AFC AFC NNP cord-015021-pol2qm74 2592 3 may may MD cord-015021-pol2qm74 2592 4 promote promote VB cord-015021-pol2qm74 2592 5 bacterial bacterial JJ cord-015021-pol2qm74 2592 6 growth growth NN cord-015021-pol2qm74 2592 7 in in IN cord-015021-pol2qm74 2592 8 vivo vivo NN cord-015021-pol2qm74 2592 9 . . . cord-015021-pol2qm74 2593 1 CRSSA CRSSA NNP cord-015021-pol2qm74 2593 2 . . . cord-015021-pol2qm74 2594 1 Unit4 Unit4 NNP cord-015021-pol2qm74 2594 2 de de NNP cord-015021-pol2qm74 2594 3 Microbiologie Microbiologie NNP cord-015021-pol2qm74 2594 4 . . . cord-015021-pol2qm74 2595 1 BP BP NNP cord-015021-pol2qm74 2595 2 87 87 CD cord-015021-pol2qm74 2595 3 . . . cord-015021-pol2qm74 2596 1 38702 38702 CD cord-015021-pol2qm74 2597 1 La La NNP cord-015021-pol2qm74 2597 2 Tronche Tronche NNP cord-015021-pol2qm74 2597 3 Cedex Cedex NNP cord-015021-pol2qm74 2597 4 FRANCE FRANCE NNP cord-015021-pol2qm74 2597 5 . . . cord-015021-pol2qm74 2598 1 Henning Henning NNP cord-015021-pol2qm74 2598 2 Jahr Jahr NNP cord-015021-pol2qm74 2598 3 , , , cord-015021-pol2qm74 2598 4 Ulrike Ulrike NNP cord-015021-pol2qm74 2598 5 Noack Noack NNP cord-015021-pol2qm74 2598 6 , , , cord-015021-pol2qm74 2598 7 Karin Karin NNP cord-015021-pol2qm74 2598 8 Braun Braun NNP cord-015021-pol2qm74 2599 1 The the DT cord-015021-pol2qm74 2599 2 large large JJ cord-015021-pol2qm74 2599 3 amounts amount NNS cord-015021-pol2qm74 2599 4 of of IN cord-015021-pol2qm74 2599 5 NO no DT cord-015021-pol2qm74 2599 6 produced produce VBN cord-015021-pol2qm74 2599 7 by by IN cord-015021-pol2qm74 2599 8 the the DT cord-015021-pol2qm74 2599 9 inducible inducible JJ cord-015021-pol2qm74 2599 10 NO no DT cord-015021-pol2qm74 2599 11 synthase synthase NN cord-015021-pol2qm74 2599 12 in in IN cord-015021-pol2qm74 2599 13 rat rat NN cord-015021-pol2qm74 2599 14 macrophages macrophage NNS cord-015021-pol2qm74 2599 15 have have VBP cord-015021-pol2qm74 2599 16 direct direct JJ cord-015021-pol2qm74 2599 17 antimicrobial antimicrobial JJ cord-015021-pol2qm74 2599 18 effects effect NNS cord-015021-pol2qm74 2599 19 , , , cord-015021-pol2qm74 2599 20 but but CC cord-015021-pol2qm74 2599 21 inhibit inhibit VB cord-015021-pol2qm74 2599 22 the the DT cord-015021-pol2qm74 2599 23 activation activation NN cord-015021-pol2qm74 2599 24 of of IN cord-015021-pol2qm74 2599 25 the the DT cord-015021-pol2qm74 2599 26 lymphocyte lymphocyte NN cord-015021-pol2qm74 2599 27 - - HYPH cord-015021-pol2qm74 2599 28 dependent dependent JJ cord-015021-pol2qm74 2599 29 host host NN cord-015021-pol2qm74 2599 30 defense defense NN cord-015021-pol2qm74 2599 31 system system NN cord-015021-pol2qm74 2599 32 . . . cord-015021-pol2qm74 2600 1 The the DT cord-015021-pol2qm74 2600 2 aim aim NN cord-015021-pol2qm74 2600 3 of of IN cord-015021-pol2qm74 2600 4 this this DT cord-015021-pol2qm74 2600 5 study study NN cord-015021-pol2qm74 2600 6 was be VBD cord-015021-pol2qm74 2600 7 to to TO cord-015021-pol2qm74 2600 8 investigate investigate VB cord-015021-pol2qm74 2600 9 if if IN cord-015021-pol2qm74 2600 10 complement complement JJ cord-015021-pol2qm74 2600 11 activation activation NN cord-015021-pol2qm74 2600 12 influences influence NNS cord-015021-pol2qm74 2600 13 NO no NN cord-015021-pol2qm74 2600 14 - - HYPH cord-015021-pol2qm74 2600 15 generation generation NN cord-015021-pol2qm74 2600 16 . . . cord-015021-pol2qm74 2601 1 Spleen spleen NN cord-015021-pol2qm74 2601 2 cells cell NNS cord-015021-pol2qm74 2601 3 from from IN cord-015021-pol2qm74 2601 4 LEW LEW NNP cord-015021-pol2qm74 2601 5 rats rat NNS cord-015021-pol2qm74 2601 6 were be VBD cord-015021-pol2qm74 2601 7 incubated incubate VBN cord-015021-pol2qm74 2601 8 at at IN cord-015021-pol2qm74 2601 9 37 37 CD cord-015021-pol2qm74 2601 10 ° ° NNS cord-015021-pol2qm74 2601 11 in in IN cord-015021-pol2qm74 2601 12 TCM-199/5 TCM-199/5 NNP cord-015021-pol2qm74 2601 13 % % NN cord-015021-pol2qm74 2601 14 FCS FCS NNP cord-015021-pol2qm74 2601 15 , , , cord-015021-pol2qm74 2601 16 with with IN cord-015021-pol2qm74 2601 17 or or CC cord-015021-pol2qm74 2601 18 without without IN cord-015021-pol2qm74 2601 19 additional additional JJ cord-015021-pol2qm74 2601 20 rat rat NN cord-015021-pol2qm74 2601 21 serum serum NN cord-015021-pol2qm74 2601 22 . . . cord-015021-pol2qm74 2602 1 After after IN cord-015021-pol2qm74 2602 2 20 20 CD cord-015021-pol2qm74 2602 3 h h NN cord-015021-pol2qm74 2602 4 , , , cord-015021-pol2qm74 2602 5 nitrite nitrite NN cord-015021-pol2qm74 2602 6 ( ( -LRB- cord-015021-pol2qm74 2602 7 end end NN cord-015021-pol2qm74 2602 8 product product NN cord-015021-pol2qm74 2602 9 from from IN cord-015021-pol2qm74 2602 10 NO no DT cord-015021-pol2qm74 2602 11 metabolism metabolism NN cord-015021-pol2qm74 2602 12 ) ) -RRB- cord-015021-pol2qm74 2602 13 was be VBD cord-015021-pol2qm74 2602 14 measured measure VBN cord-015021-pol2qm74 2602 15 by by IN cord-015021-pol2qm74 2602 16 Oriess Oriess NNP cord-015021-pol2qm74 2602 17 reagent reagent NN cord-015021-pol2qm74 2602 18 . . . cord-015021-pol2qm74 2603 1 In in IN cord-015021-pol2qm74 2603 2 rat rat NN cord-015021-pol2qm74 2603 3 spleen spleen NN cord-015021-pol2qm74 2603 4 cell cell NN cord-015021-pol2qm74 2603 5 preparations preparation NNS cord-015021-pol2qm74 2603 6 , , , cord-015021-pol2qm74 2603 7 most most JJS cord-015021-pol2qm74 2603 8 of of IN cord-015021-pol2qm74 2603 9 the the DT cord-015021-pol2qm74 2603 10 NO no NN cord-015021-pol2qm74 2603 11 is be VBZ cord-015021-pol2qm74 2603 12 produced produce VBN cord-015021-pol2qm74 2603 13 by by IN cord-015021-pol2qm74 2603 14 macrophages macrophage NNS cord-015021-pol2qm74 2603 15 . . . cord-015021-pol2qm74 2604 1 Complement complement JJ cord-015021-pol2qm74 2604 2 activation activation NN cord-015021-pol2qm74 2604 3 in in IN cord-015021-pol2qm74 2604 4 vivo vivo NN cord-015021-pol2qm74 2604 5 was be VBD cord-015021-pol2qm74 2604 6 carried carry VBN cord-015021-pol2qm74 2604 7 out out RP cord-015021-pol2qm74 2604 8 by by IN cord-015021-pol2qm74 2604 9 i.v i.v NNP cord-015021-pol2qm74 2604 10 . . . cord-015021-pol2qm74 2604 11 injections injection NNS cord-015021-pol2qm74 2604 12 of of IN cord-015021-pol2qm74 2604 13 240 240 CD cord-015021-pol2qm74 2604 14 U U NNP cord-015021-pol2qm74 2604 15 cobra cobra NN cord-015021-pol2qm74 2604 16 venom venom NN cord-015021-pol2qm74 2604 17 factor factor NN cord-015021-pol2qm74 2604 18 / / SYM cord-015021-pol2qm74 2604 19 kg kg NN cord-015021-pol2qm74 2604 20 b.w b.w NNP cord-015021-pol2qm74 2604 21 . . . cord-015021-pol2qm74 2605 1 at at IN cord-015021-pol2qm74 2605 2 days day NNS cord-015021-pol2qm74 2605 3 0 0 CD cord-015021-pol2qm74 2605 4 and and CC cord-015021-pol2qm74 2605 5 2 2 CD cord-015021-pol2qm74 2605 6 . . . cord-015021-pol2qm74 2606 1 Significantly significantly RB cord-015021-pol2qm74 2606 2 higher high JJR cord-015021-pol2qm74 2607 1 ( ( -LRB- cord-015021-pol2qm74 2607 2 P p NN cord-015021-pol2qm74 2607 3 < < XX cord-015021-pol2qm74 2607 4 O.O1 o.o1 NN cord-015021-pol2qm74 2607 5 ) ) -RRB- cord-015021-pol2qm74 2607 6 LPS lps NN cord-015021-pol2qm74 2607 7 - - HYPH cord-015021-pol2qm74 2607 8 stimulated stimulate VBN cord-015021-pol2qm74 2607 9 NO no NN cord-015021-pol2qm74 2607 10 - - HYPH cord-015021-pol2qm74 2607 11 generation generation NN cord-015021-pol2qm74 2607 12 was be VBD cord-015021-pol2qm74 2607 13 found find VBN cord-015021-pol2qm74 2607 14 in in IN cord-015021-pol2qm74 2607 15 spleen spleen NN cord-015021-pol2qm74 2607 16 cells cell NNS cord-015021-pol2qm74 2607 17 prepared prepare VBN cord-015021-pol2qm74 2607 18 at at IN cord-015021-pol2qm74 2607 19 day day NN cord-015021-pol2qm74 2607 20 4 4 CD cord-015021-pol2qm74 2607 21 ( ( -LRB- cord-015021-pol2qm74 2607 22 13.0 13.0 CD cord-015021-pol2qm74 2607 23 4 4 CD cord-015021-pol2qm74 2607 24 - - SYM cord-015021-pol2qm74 2607 25 1.3 1.3 CD cord-015021-pol2qm74 2607 26 nmol nmol NN cord-015021-pol2qm74 2607 27 nitrite/106 nitrite/106 NNP cord-015021-pol2qm74 2607 28 cells cell NNS cord-015021-pol2qm74 2607 29 , , , cord-015021-pol2qm74 2607 30 n=6 n=6 JJ cord-015021-pol2qm74 2607 31 ) ) -RRB- cord-015021-pol2qm74 2607 32 compared compare VBN cord-015021-pol2qm74 2607 33 to to IN cord-015021-pol2qm74 2607 34 spleen spleen NN cord-015021-pol2qm74 2607 35 cells cell NNS cord-015021-pol2qm74 2607 36 from from IN cord-015021-pol2qm74 2607 37 non non JJ cord-015021-pol2qm74 2607 38 - - JJ cord-015021-pol2qm74 2607 39 treated treat VBN cord-015021-pol2qm74 2607 40 animals animal NNS cord-015021-pol2qm74 2607 41 ( ( -LRB- cord-015021-pol2qm74 2607 42 3.6 3.6 CD cord-015021-pol2qm74 2607 43 ± ± CD cord-015021-pol2qm74 2607 44 1.3 1.3 CD cord-015021-pol2qm74 2607 45 nmol nmol NN cord-015021-pol2qm74 2607 46 , , , cord-015021-pol2qm74 2607 47 n=6 n=6 JJ cord-015021-pol2qm74 2607 48 ) ) -RRB- cord-015021-pol2qm74 2608 1 Complement complement JJ cord-015021-pol2qm74 2608 2 activation activation NN cord-015021-pol2qm74 2608 3 was be VBD cord-015021-pol2qm74 2608 4 effective effective JJ cord-015021-pol2qm74 2608 5 also also RB cord-015021-pol2qm74 2608 6 in in IN cord-015021-pol2qm74 2608 7 vitro vitro FW cord-015021-pol2qm74 2608 8 . . . cord-015021-pol2qm74 2609 1 When when WRB cord-015021-pol2qm74 2609 2 incubated incubate VBN cord-015021-pol2qm74 2609 3 in in IN cord-015021-pol2qm74 2609 4 25 25 CD cord-015021-pol2qm74 2609 5 % % NN cord-015021-pol2qm74 2609 6 zymosan zymosan NNP cord-015021-pol2qm74 2609 7 - - HYPH cord-015021-pol2qm74 2609 8 activated activate VBN cord-015021-pol2qm74 2609 9 rat rat NN cord-015021-pol2qm74 2609 10 serum serum NN cord-015021-pol2qm74 2609 11 , , , cord-015021-pol2qm74 2609 12 both both CC cord-015021-pol2qm74 2609 13 basal basal NN cord-015021-pol2qm74 2609 14 and and CC cord-015021-pol2qm74 2609 15 LPS LPS NNP cord-015021-pol2qm74 2609 16 - - HYPH cord-015021-pol2qm74 2609 17 stimulated stimulate VBN cord-015021-pol2qm74 2609 18 NOproduction NOproduction NNP cord-015021-pol2qm74 2609 19 were be VBD cord-015021-pol2qm74 2609 20 enhanced enhance VBN cord-015021-pol2qm74 2609 21 in in IN cord-015021-pol2qm74 2609 22 spleen spleen NN cord-015021-pol2qm74 2609 23 cells cell NNS cord-015021-pol2qm74 2609 24 ( ( -LRB- cord-015021-pol2qm74 2609 25 Table table NN cord-015021-pol2qm74 2609 26 , , , cord-015021-pol2qm74 2609 27 values value NNS cord-015021-pol2qm74 2609 28 Increased increase VBN cord-015021-pol2qm74 2609 29 production production NN cord-015021-pol2qm74 2609 30 of of IN cord-015021-pol2qm74 2609 31 Nitric nitric NN cord-015021-pol2qm74 2609 32 Oxide oxide NN cord-015021-pol2qm74 2610 1 ( ( -LRB- cord-015021-pol2qm74 2610 2 NO no UH cord-015021-pol2qm74 2610 3 ) ) -RRB- cord-015021-pol2qm74 2610 4 is be VBZ cord-015021-pol2qm74 2610 5 associated associate VBN cord-015021-pol2qm74 2610 6 with with IN cord-015021-pol2qm74 2610 7 sepsis sepsis NN cord-015021-pol2qm74 2610 8 , , , cord-015021-pol2qm74 2610 9 however however RB cord-015021-pol2qm74 2610 10 , , , cord-015021-pol2qm74 2610 11 the the DT cord-015021-pol2qm74 2610 12 effect effect NN cord-015021-pol2qm74 2610 13 of of IN cord-015021-pol2qm74 2610 14 NO no DT cord-015021-pol2qm74 2610 15 inhibition inhibition NN cord-015021-pol2qm74 2610 16 on on IN cord-015021-pol2qm74 2610 17 survival survival NN cord-015021-pol2qm74 2610 18 during during IN cord-015021-pol2qm74 2610 19 sepsis sepsis NN cord-015021-pol2qm74 2610 20 is be VBZ cord-015021-pol2qm74 2610 21 unclear unclear JJ cord-015021-pol2qm74 2610 22 . . . cord-015021-pol2qm74 2611 1 We -PRON- PRP cord-015021-pol2qm74 2611 2 examined examine VBD cord-015021-pol2qm74 2611 3 the the DT cord-015021-pol2qm74 2611 4 effect effect NN cord-015021-pol2qm74 2611 5 of of IN cord-015021-pol2qm74 2611 6 NO no DT cord-015021-pol2qm74 2611 7 inhibition inhibition NN cord-015021-pol2qm74 2611 8 on on IN cord-015021-pol2qm74 2611 9 host host NN cord-015021-pol2qm74 2611 10 's 's POS cord-015021-pol2qm74 2611 11 ability ability NN cord-015021-pol2qm74 2611 12 to to TO cord-015021-pol2qm74 2611 13 eliminate eliminate VB cord-015021-pol2qm74 2611 14 bacteria bacteria NNS cord-015021-pol2qm74 2611 15 and and CC cord-015021-pol2qm74 2611 16 survival survival NN cord-015021-pol2qm74 2611 17 in in IN cord-015021-pol2qm74 2611 18 mice mouse NNS cord-015021-pol2qm74 2611 19 sepsis sepsis NN cord-015021-pol2qm74 2611 20 model model NN cord-015021-pol2qm74 2611 21 . . . cord-015021-pol2qm74 2612 1 Sixty sixty CD cord-015021-pol2qm74 2612 2 female female NN cord-015021-pol2qm74 2612 3 Balb Balb NNP cord-015021-pol2qm74 2612 4 / / SYM cord-015021-pol2qm74 2612 5 c c NN cord-015021-pol2qm74 2612 6 mice mouse NNS cord-015021-pol2qm74 2612 7 were be VBD cord-015021-pol2qm74 2612 8 injected inject VBN cord-015021-pol2qm74 2612 9 with with IN cord-015021-pol2qm74 2612 10 E.coli E.coli NNS cord-015021-pol2qm74 2612 11 ( ( -LRB- cord-015021-pol2qm74 2612 12 10qbody 10qbody CD cord-015021-pol2qm74 2612 13 ) ) -RRB- cord-015021-pol2qm74 2612 14 into into IN cord-015021-pol2qm74 2612 15 peritoneal peritoneal JJ cord-015021-pol2qm74 2612 16 cavity cavity NN cord-015021-pol2qm74 2612 17 . . . cord-015021-pol2qm74 2613 1 The the DT cord-015021-pol2qm74 2613 2 treated treated JJ cord-015021-pol2qm74 2613 3 group group NN cord-015021-pol2qm74 2613 4 received receive VBD cord-015021-pol2qm74 2613 5 N N NNP cord-015021-pol2qm74 2613 6 - - HYPH cord-015021-pol2qm74 2613 7 ultro ultro NNP cord-015021-pol2qm74 2613 8 - - HYPH cord-015021-pol2qm74 2613 9 l l NN cord-015021-pol2qm74 2613 10 - - HYPH cord-015021-pol2qm74 2613 11 arginine arginine NN cord-015021-pol2qm74 2613 12 - - HYPH cord-015021-pol2qm74 2613 13 methyl methyl NN cord-015021-pol2qm74 2613 14 - - HYPH cord-015021-pol2qm74 2613 15 ester ester NN cord-015021-pol2qm74 2613 16 ( ( -LRB- cord-015021-pol2qm74 2613 17 L l NN cord-015021-pol2qm74 2613 18 - - HYPH cord-015021-pol2qm74 2613 19 NAME NAME NNP cord-015021-pol2qm74 2613 20 ) ) -RRB- cord-015021-pol2qm74 2613 21 , , , cord-015021-pol2qm74 2613 22 an an DT cord-015021-pol2qm74 2613 23 inhibitor inhibitor NN cord-015021-pol2qm74 2613 24 of of IN cord-015021-pol2qm74 2613 25 NOS NOS NNP cord-015021-pol2qm74 2613 26 , , , cord-015021-pol2qm74 2613 27 one one CD cord-015021-pol2qm74 2613 28 hour hour NN cord-015021-pol2qm74 2613 29 before before IN cord-015021-pol2qm74 2613 30 bacterial bacterial JJ cord-015021-pol2qm74 2613 31 challenge challenge NN cord-015021-pol2qm74 2613 32 . . . cord-015021-pol2qm74 2614 1 Thirty thirty CD cord-015021-pol2qm74 2614 2 mice mouse NNS cord-015021-pol2qm74 2614 3 were be VBD cord-015021-pol2qm74 2614 4 observed observe VBN cord-015021-pol2qm74 2614 5 for for IN cord-015021-pol2qm74 2614 6 survival survival NN cord-015021-pol2qm74 2614 7 after after IN cord-015021-pol2qm74 2614 8 E.coli e.coli NN cord-015021-pol2qm74 2614 9 challenge challenge NN cord-015021-pol2qm74 2614 10 and and CC cord-015021-pol2qm74 2614 11 the the DT cord-015021-pol2qm74 2614 12 other other JJ cord-015021-pol2qm74 2614 13 mice mouse NNS cord-015021-pol2qm74 2614 14 were be VBD cord-015021-pol2qm74 2614 15 sacrificed sacrifice VBN cord-015021-pol2qm74 2614 16 at at IN cord-015021-pol2qm74 2614 17 4 4 CD cord-015021-pol2qm74 2614 18 hours hour NNS cord-015021-pol2qm74 2614 19 . . . cord-015021-pol2qm74 2615 1 Blood blood NN cord-015021-pol2qm74 2615 2 was be VBD cord-015021-pol2qm74 2615 3 obtained obtain VBN cord-015021-pol2qm74 2615 4 by by IN cord-015021-pol2qm74 2615 5 cardiac cardiac JJ cord-015021-pol2qm74 2615 6 puncture puncture NN cord-015021-pol2qm74 2615 7 and and CC cord-015021-pol2qm74 2615 8 peritoneal peritoneal JJ cord-015021-pol2qm74 2615 9 lavage lavage NN cord-015021-pol2qm74 2615 10 fluid fluid NN cord-015021-pol2qm74 2615 11 ( ( -LRB- cord-015021-pol2qm74 2615 12 PLF PLF NNP cord-015021-pol2qm74 2615 13 ) ) -RRB- cord-015021-pol2qm74 2615 14 , , , cord-015021-pol2qm74 2615 15 liver liver NN cord-015021-pol2qm74 2615 16 and and CC cord-015021-pol2qm74 2615 17 lung lung NN cord-015021-pol2qm74 2615 18 were be VBD cord-015021-pol2qm74 2615 19 harvested harvest VBN cord-015021-pol2qm74 2615 20 . . . cord-015021-pol2qm74 2616 1 The the DT cord-015021-pol2qm74 2616 2 number number NN cord-015021-pol2qm74 2616 3 of of IN cord-015021-pol2qm74 2616 4 peritoneal peritoneal JJ cord-015021-pol2qm74 2616 5 exudative exudative JJ cord-015021-pol2qm74 2616 6 cell cell NN cord-015021-pol2qm74 2616 7 ( ( -LRB- cord-015021-pol2qm74 2616 8 PEC PEC NNP cord-015021-pol2qm74 2616 9 ) ) -RRB- cord-015021-pol2qm74 2616 10 was be VBD cord-015021-pol2qm74 2616 11 counted count VBN cord-015021-pol2qm74 2616 12 and and CC cord-015021-pol2qm74 2616 13 colony colony NN cord-015021-pol2qm74 2616 14 forming form VBG cord-015021-pol2qm74 2616 15 units unit NNS cord-015021-pol2qm74 2616 16 ( ( -LRB- cord-015021-pol2qm74 2616 17 CFLD CFLD NNP cord-015021-pol2qm74 2616 18 of of IN cord-015021-pol2qm74 2616 19 bacteria bacteria NNS cord-015021-pol2qm74 2616 20 in in IN cord-015021-pol2qm74 2616 21 the the DT cord-015021-pol2qm74 2616 22 tissues tissue NNS cord-015021-pol2qm74 2616 23 , , , cord-015021-pol2qm74 2616 24 blood blood NN cord-015021-pol2qm74 2616 25 , , , cord-015021-pol2qm74 2616 26 and and CC cord-015021-pol2qm74 2616 27 PLF PLF NNP cord-015021-pol2qm74 2616 28 were be VBD cord-015021-pol2qm74 2616 29 also also RB cord-015021-pol2qm74 2616 30 determined determine VBN cord-015021-pol2qm74 2616 31 . . . cord-015021-pol2qm74 2617 1 In in IN cord-015021-pol2qm74 2617 2 addition addition NN cord-015021-pol2qm74 2617 3 , , , cord-015021-pol2qm74 2617 4 PEC PEC NNP cord-015021-pol2qm74 2617 5 was be VBD cord-015021-pol2qm74 2617 6 cultured culture VBN cord-015021-pol2qm74 2617 7 in in IN cord-015021-pol2qm74 2617 8 vitro vitro FW cord-015021-pol2qm74 2617 9 with with IN cord-015021-pol2qm74 2617 10 or or CC cord-015021-pol2qm74 2617 11 without without IN cord-015021-pol2qm74 2617 12 lipopolysaecharide lipopolysaecharide NN cord-015021-pol2qm74 2617 13 ( ( -LRB- cord-015021-pol2qm74 2617 14 LPS LPS NNP cord-015021-pol2qm74 2617 15 ) ) -RRB- cord-015021-pol2qm74 2617 16 . . . cord-015021-pol2qm74 2618 1 TNF TNF NNP cord-015021-pol2qm74 2618 2 levels level NNS cord-015021-pol2qm74 2618 3 in in IN cord-015021-pol2qm74 2618 4 the the DT cord-015021-pol2qm74 2618 5 blood blood NN cord-015021-pol2qm74 2618 6 , , , cord-015021-pol2qm74 2618 7 PLF PLF NNP cord-015021-pol2qm74 2618 8 , , , cord-015021-pol2qm74 2618 9 and and CC cord-015021-pol2qm74 2618 10 supematants supematant NNS cord-015021-pol2qm74 2618 11 of of IN cord-015021-pol2qm74 2618 12 cultured cultured JJ cord-015021-pol2qm74 2618 13 PEC PEC NNP cord-015021-pol2qm74 2618 14 were be VBD cord-015021-pol2qm74 2618 15 measured measure VBN cord-015021-pol2qm74 2618 16 by by IN cord-015021-pol2qm74 2618 17 L929 l929 CD cord-015021-pol2qm74 2618 18 bioassay bioassay NN cord-015021-pol2qm74 2618 19 . . . cord-015021-pol2qm74 2619 1 Survival survival NN cord-015021-pol2qm74 2619 2 Rate rate NN cord-015021-pol2qm74 2619 3 ( ( -LRB- cord-015021-pol2qm74 2619 4 % % NN cord-015021-pol2qm74 2619 5 ) ) -RRB- cord-015021-pol2qm74 2620 1 Qrql/,p Qrql/,p NNP cord-015021-pol2qm74 2620 2 n n NN cord-015021-pol2qm74 2620 3 8 8 CD cord-015021-pol2qm74 2620 4 hr hr NN cord-015021-pol2qm74 2620 5 24 24 CD cord-015021-pol2qm74 2620 6 hr hr NN cord-015021-pol2qm74 2620 7 4 4 CD cord-015021-pol2qm74 2620 8 dav dav NN cord-015021-pol2qm74 2620 9 control control NN cord-015021-pol2qm74 2620 10 ( ( -LRB- cord-015021-pol2qm74 2620 11 normal normal JJ cord-015021-pol2qm74 2620 12 saline saline NN cord-015021-pol2qm74 2620 13 0.1ml 0.1ml CD cord-015021-pol2qm74 2620 14 / / SYM cord-015021-pol2qm74 2620 15 body body NN cord-015021-pol2qm74 2620 16 i.p i.p NNP cord-015021-pol2qm74 2620 17 . . NNP cord-015021-pol2qm74 2620 18 ) ) -RRB- cord-015021-pol2qm74 2620 19 10 10 CD cord-015021-pol2qm74 2620 20 100 100 CD cord-015021-pol2qm74 2621 1 50 50 CD cord-015021-pol2qm74 2621 2 40 40 CD cord-015021-pol2qm74 2621 3 N10 N10 NNP cord-015021-pol2qm74 2621 4 ( ( -LRB- cord-015021-pol2qm74 2621 5 L L NNP cord-015021-pol2qm74 2621 6 - - HYPH cord-015021-pol2qm74 2621 7 NAME NAME NNP cord-015021-pol2qm74 2621 8 10mg 10mg NNP cord-015021-pol2qm74 2621 9 / / SYM cord-015021-pol2qm74 2621 10 kg kg NNP cord-015021-pol2qm74 2621 11 i. i. NNP cord-015021-pol2qm74 2621 12 Administration Administration NNP cord-015021-pol2qm74 2621 13 of of IN cord-015021-pol2qm74 2621 14 L L NNP cord-015021-pol2qm74 2621 15 - - HYPH cord-015021-pol2qm74 2621 16 NAME name NN cord-015021-pol2qm74 2621 17 before before IN cord-015021-pol2qm74 2621 18 E.coli E.coli NNS cord-015021-pol2qm74 2621 19 injection injection NN cord-015021-pol2qm74 2621 20 increased increase VBD cord-015021-pol2qm74 2621 21 the the DT cord-015021-pol2qm74 2621 22 number number NN cord-015021-pol2qm74 2621 23 of of IN cord-015021-pol2qm74 2621 24 bacteria bacteria NNS cord-015021-pol2qm74 2621 25 in in IN cord-015021-pol2qm74 2621 26 PLF PLF NNP cord-015021-pol2qm74 2621 27 and and CC cord-015021-pol2qm74 2621 28 TNF TNF NNP cord-015021-pol2qm74 2621 29 level level NN cord-015021-pol2qm74 2621 30 in in IN cord-015021-pol2qm74 2621 31 plasma plasma NN cord-015021-pol2qm74 2621 32 , , , cord-015021-pol2qm74 2621 33 The the DT cord-015021-pol2qm74 2621 34 result result NN cord-015021-pol2qm74 2621 35 suggests suggest VBZ cord-015021-pol2qm74 2621 36 that that IN cord-015021-pol2qm74 2621 37 NOS NOS NNP cord-015021-pol2qm74 2621 38 inhibitor inhibitor NN cord-015021-pol2qm74 2621 39 may may MD cord-015021-pol2qm74 2621 40 depress depress VB cord-015021-pol2qm74 2621 41 the the DT cord-015021-pol2qm74 2621 42 host host NN cord-015021-pol2qm74 2621 43 's 's POS cord-015021-pol2qm74 2621 44 ability ability NN cord-015021-pol2qm74 2621 45 to to TO cord-015021-pol2qm74 2621 46 kill kill VB cord-015021-pol2qm74 2621 47 the the DT cord-015021-pol2qm74 2621 48 injected inject VBN cord-015021-pol2qm74 2621 49 bacteria bacteria NNS cord-015021-pol2qm74 2621 50 and and CC cord-015021-pol2qm74 2621 51 that that IN cord-015021-pol2qm74 2621 52 it -PRON- PRP cord-015021-pol2qm74 2621 53 may may MD cord-015021-pol2qm74 2621 54 induce induce VB cord-015021-pol2qm74 2621 55 greater great JJR cord-015021-pol2qm74 2621 56 systemic systemic JJ cord-015021-pol2qm74 2621 57 TNF tnf NN cord-015021-pol2qm74 2621 58 production production NN cord-015021-pol2qm74 2621 59 . . . cord-015021-pol2qm74 2622 1 We -PRON- PRP cord-015021-pol2qm74 2622 2 conclude conclude VBP cord-015021-pol2qm74 2622 3 that that IN cord-015021-pol2qm74 2622 4 NOS NOS NNP cord-015021-pol2qm74 2622 5 inhibitor inhibitor NN cord-015021-pol2qm74 2622 6 is be VBZ cord-015021-pol2qm74 2622 7 detrimental detrimental JJ cord-015021-pol2qm74 2622 8 to to IN cord-015021-pol2qm74 2622 9 animals animal NNS cord-015021-pol2qm74 2622 10 in in IN cord-015021-pol2qm74 2622 11 sepsis sepsis NN cord-015021-pol2qm74 2622 12 . . . cord-015021-pol2qm74 2623 1 The the DT cord-015021-pol2qm74 2623 2 hypothesis hypothesis NN cord-015021-pol2qm74 2623 3 that that IN cord-015021-pol2qm74 2623 4 SOD SOD NNP cord-015021-pol2qm74 2623 5 prevents prevent VBZ cord-015021-pol2qm74 2623 6 reperfusion reperfusion NN cord-015021-pol2qm74 2623 7 injury injury NN cord-015021-pol2qm74 2623 8 to to IN cord-015021-pol2qm74 2623 9 the the DT cord-015021-pol2qm74 2623 10 liver liver NN cord-015021-pol2qm74 2623 11 by by IN cord-015021-pol2qm74 2623 12 protecting protect VBG cord-015021-pol2qm74 2623 13 the the DT cord-015021-pol2qm74 2623 14 endogenous endogenous JJ cord-015021-pol2qm74 2623 15 endothelium endothelium NN cord-015021-pol2qm74 2623 16 derived derive VBN cord-015021-pol2qm74 2623 17 vascular vascular JJ cord-015021-pol2qm74 2623 18 relaxing relaxing JJ cord-015021-pol2qm74 2623 19 factor factor NN cord-015021-pol2qm74 2623 20 ( ( -LRB- cord-015021-pol2qm74 2623 21 NO no UH cord-015021-pol2qm74 2623 22 ) ) -RRB- cord-015021-pol2qm74 2623 23 from from IN cord-015021-pol2qm74 2623 24 being be VBG cord-015021-pol2qm74 2623 25 inactivated inactivate VBN cord-015021-pol2qm74 2623 26 by by IN cord-015021-pol2qm74 2623 27 oxygen oxygen NN cord-015021-pol2qm74 2623 28 free free JJ cord-015021-pol2qm74 2623 29 radicals radical NNS cord-015021-pol2qm74 2623 30 should should MD cord-015021-pol2qm74 2623 31 be be VB cord-015021-pol2qm74 2623 32 investigated investigate VBN cord-015021-pol2qm74 2623 33 . . . cord-015021-pol2qm74 2624 1 Male male JJ cord-015021-pol2qm74 2624 2 Wistar Wistar NNP cord-015021-pol2qm74 2624 3 rats rat NNS cord-015021-pol2qm74 2624 4 were be VBD cord-015021-pol2qm74 2624 5 subjected subject VBN cord-015021-pol2qm74 2624 6 to to IN cord-015021-pol2qm74 2624 7 60 60 CD cord-015021-pol2qm74 2624 8 min min NN cord-015021-pol2qm74 2624 9 of of IN cord-015021-pol2qm74 2624 10 partial partial JJ cord-015021-pol2qm74 2624 11 liver liver NN cord-015021-pol2qm74 2624 12 ischemia ischemia NN cord-015021-pol2qm74 2624 13 ( ( -LRB- cord-015021-pol2qm74 2624 14 70 70 CD cord-015021-pol2qm74 2624 15 % % NN cord-015021-pol2qm74 2624 16 ) ) -RRB- cord-015021-pol2qm74 2624 17 and and CC cord-015021-pol2qm74 2624 18 30 30 CD cord-015021-pol2qm74 2624 19 min min NN cord-015021-pol2qm74 2624 20 of of IN cord-015021-pol2qm74 2624 21 consecutive consecutive JJ cord-015021-pol2qm74 2624 22 reperfusion reperfusion NN cord-015021-pol2qm74 2624 23 in in IN cord-015021-pol2qm74 2624 24 situ situ NN cord-015021-pol2qm74 2624 25 . . . cord-015021-pol2qm74 2625 1 Some some DT cord-015021-pol2qm74 2625 2 rats rat NNS cord-015021-pol2qm74 2625 3 were be VBD cord-015021-pol2qm74 2625 4 pretreated pretreate VBN cord-015021-pol2qm74 2625 5 with with IN cord-015021-pol2qm74 2625 6 the the DT cord-015021-pol2qm74 2625 7 NO no DT cord-015021-pol2qm74 2625 8 synthase synthase NN cord-015021-pol2qm74 2625 9 inhibitor inhibitor NN cord-015021-pol2qm74 2625 10 nitro nitro NN cord-015021-pol2qm74 2625 11 - - HYPH cord-015021-pol2qm74 2625 12 L L NNP cord-015021-pol2qm74 2625 13 - - HYPH cord-015021-pol2qm74 2625 14 Arginin Arginin NNP cord-015021-pol2qm74 2625 15 ( ( -LRB- cord-015021-pol2qm74 2625 16 NLA NLA NNP cord-015021-pol2qm74 2625 17 : : : cord-015021-pol2qm74 2625 18 I0 I0 NNP cord-015021-pol2qm74 2625 19 mg mg NNP cord-015021-pol2qm74 2625 20 / / SYM cord-015021-pol2qm74 2625 21 kg kg NNP cord-015021-pol2qm74 2625 22 ) ) -RRB- cord-015021-pol2qm74 2625 23 . . . cord-015021-pol2qm74 2626 1 SOD SOD NNP cord-015021-pol2qm74 2626 2 , , , cord-015021-pol2qm74 2626 3 when when WRB cord-015021-pol2qm74 2626 4 used use VBN cord-015021-pol2qm74 2626 5 , , , cord-015021-pol2qm74 2626 6 was be VBD cord-015021-pol2qm74 2626 7 given give VBN cord-015021-pol2qm74 2626 8 as as IN cord-015021-pol2qm74 2626 9 Mn Mn NNP cord-015021-pol2qm74 2626 10 - - HYPH cord-015021-pol2qm74 2626 11 containing contain VBG cord-015021-pol2qm74 2626 12 preparation preparation NN cord-015021-pol2qm74 2626 13 at at IN cord-015021-pol2qm74 2626 14 a a DT cord-015021-pol2qm74 2626 15 dose dose NN cord-015021-pol2qm74 2626 16 of of IN cord-015021-pol2qm74 2626 17 6000 6000 CD cord-015021-pol2qm74 2626 18 U. U. NNP cord-015021-pol2qm74 2626 19 i.v i.v NNP cord-015021-pol2qm74 2626 20 . . . cord-015021-pol2qm74 2626 21 i0 i0 NNP cord-015021-pol2qm74 2626 22 min min NNP cord-015021-pol2qm74 2626 23 prior prior RB cord-015021-pol2qm74 2626 24 to to IN cord-015021-pol2qm74 2626 25 ischemia ischemia NN cord-015021-pol2qm74 2626 26 . . . cord-015021-pol2qm74 2627 1 Results result NNS cord-015021-pol2qm74 2627 2 ( ( -LRB- cord-015021-pol2qm74 2627 3 SOD/ SOD/ NNP cord-015021-pol2qm74 2627 4 NLA+SOD/ nla+sod/ CD cord-015021-pol2qm74 2627 5 NI~ NI~ NNP cord-015021-pol2qm74 2627 6 , , , cord-015021-pol2qm74 2627 7 , , , cord-015021-pol2qm74 2627 8 respectively respectively RB cord-015021-pol2qm74 2627 9 ) ) -RRB- cord-015021-pol2qm74 2627 10 : : : cord-015021-pol2qm74 2628 1 Bile bile NN cord-015021-pol2qm74 2628 2 flow flow NN cord-015021-pol2qm74 2628 3 ( ( -LRB- cord-015021-pol2qm74 2629 1 ~i ~i NNP cord-015021-pol2qm74 2629 2 / / SYM cord-015021-pol2qm74 2629 3 g g NN cord-015021-pol2qm74 2629 4 / / SYM cord-015021-pol2qm74 2629 5 min min NN cord-015021-pol2qm74 2629 6 ) ) -RRB- cord-015021-pol2qm74 2629 7 : : : cord-015021-pol2qm74 2630 1 0.93±0.11"#/ 0.93±0.11"#/ CD cord-015021-pol2qm74 2630 2 0.52±0.08/ 0.52±0.08/ CD cord-015021-pol2qm74 2631 1 0.48±0.05 0.48±0.05 CD cord-015021-pol2qm74 2631 2 . . . cord-015021-pol2qm74 2632 1 ALT ALT NNP cord-015021-pol2qm74 2632 2 ( ( -LRB- cord-015021-pol2qm74 2632 3 U/2 U/2 NNP cord-015021-pol2qm74 2632 4 ) ) -RRB- cord-015021-pol2qm74 2633 1 • • NNP cord-015021-pol2qm74 2634 1 171±40~#/ 171±40~#/ CD cord-015021-pol2qm74 2635 1 477±173/ 477±173/ CD cord-015021-pol2qm74 2635 2 506±182 506±182 CD cord-015021-pol2qm74 2635 3 . . . cord-015021-pol2qm74 2636 1 GLDH GLDH NNP cord-015021-pol2qm74 2637 1 ( ( -LRB- cord-015021-pol2qm74 2637 2 U U NNP cord-015021-pol2qm74 2637 3 / / SYM cord-015021-pol2qm74 2637 4 l l NN cord-015021-pol2qm74 2637 5 ) ) -RRB- cord-015021-pol2qm74 2637 6 : : : cord-015021-pol2qm74 2638 1 5.2±1.2e#/ 5.2±1.2e#/ CD cord-015021-pol2qm74 2638 2 10.7±4.2#/ 10.7±4.2#/ CD cord-015021-pol2qm74 2638 3 24.3±9.1 24.3±9.1 CD cord-015021-pol2qm74 2638 4 . . . cord-015021-pol2qm74 2639 1 In in IN cord-015021-pol2qm74 2639 2 absence absence NN cord-015021-pol2qm74 2639 3 of of IN cord-015021-pol2qm74 2639 4 NLA NLA NNP cord-015021-pol2qm74 2639 5 , , , cord-015021-pol2qm74 2639 6 SOD SOD NNP cord-015021-pol2qm74 2639 7 enhanced enhance VBN cord-015021-pol2qm74 2639 8 postischemic postischemic JJ cord-015021-pol2qm74 2639 9 bile bile NN cord-015021-pol2qm74 2639 10 flow flow NN cord-015021-pol2qm74 2639 11 and and CC cord-015021-pol2qm74 2639 12 reduced reduce VBN cord-015021-pol2qm74 2639 13 leakage leakage NN cord-015021-pol2qm74 2639 14 of of IN cord-015021-pol2qm74 2639 15 ALT alt NN cord-015021-pol2qm74 2639 16 and and CC cord-015021-pol2qm74 2639 17 GLDH GLDH NNP cord-015021-pol2qm74 2639 18 into into IN cord-015021-pol2qm74 2639 19 the the DT cord-015021-pol2qm74 2639 20 plasma plasma NN cord-015021-pol2qm74 2639 21 , , , cord-015021-pol2qm74 2639 22 while while IN cord-015021-pol2qm74 2639 23 the the DT cord-015021-pol2qm74 2639 24 effects effect NNS cord-015021-pol2qm74 2639 25 of of IN cord-015021-pol2qm74 2639 26 SOD SOD NNP cord-015021-pol2qm74 2639 27 disappeared disappear VBD cord-015021-pol2qm74 2639 28 , , , cord-015021-pol2qm74 2639 29 when when WRB cord-015021-pol2qm74 2639 30 endogenous endogenous JJ cord-015021-pol2qm74 2639 31 140~synthesis 140~synthesis CD cord-015021-pol2qm74 2639 32 was be VBD cord-015021-pol2qm74 2639 33 inhibited inhibit VBN cord-015021-pol2qm74 2639 34 by by IN cord-015021-pol2qm74 2639 35 NLA NLA NNP cord-015021-pol2qm74 2639 36 . . . cord-015021-pol2qm74 2640 1 NLA NLA NNP cord-015021-pol2qm74 2640 2 had have VBD cord-015021-pol2qm74 2640 3 no no DT cord-015021-pol2qm74 2640 4 ~ffect ~ffect XX cord-015021-pol2qm74 2640 5 on on IN cord-015021-pol2qm74 2640 6 untreated untreated JJ cord-015021-pol2qm74 2640 7 animals animal NNS cord-015021-pol2qm74 2640 8 submitted submit VBN cord-015021-pol2qm74 2640 9 to to IN cord-015021-pol2qm74 2640 10 the the DT cord-015021-pol2qm74 2640 11 same same JJ cord-015021-pol2qm74 2640 12 protocol protocol NN cord-015021-pol2qm74 2640 13 . . . cord-015021-pol2qm74 2641 1 These these DT cord-015021-pol2qm74 2641 2 results result NNS cord-015021-pol2qm74 2641 3 may may MD cord-015021-pol2qm74 2641 4 suggest suggest VB cord-015021-pol2qm74 2641 5 , , , cord-015021-pol2qm74 2641 6 that that IN cord-015021-pol2qm74 2641 7 oxygen oxygen NN cord-015021-pol2qm74 2641 8 free free JJ cord-015021-pol2qm74 2641 9 radicals radical NNS cord-015021-pol2qm74 2641 10 interfe~:e interfe~:e XX cord-015021-pol2qm74 2641 11 with with IN cord-015021-pol2qm74 2641 12 the the DT cord-015021-pol2qm74 2641 13 endogenous endogenous JJ cord-015021-pol2qm74 2641 14 vasodilator vasodilator NN cord-015021-pol2qm74 2641 15 NO no UH cord-015021-pol2qm74 2641 16 and and CC cord-015021-pol2qm74 2641 17 that that IN cord-015021-pol2qm74 2641 18 the the DT cord-015021-pol2qm74 2641 19 benefit benefit NN cord-015021-pol2qm74 2641 20 of of IN cord-015021-pol2qm74 2641 21 SOD SOD NNP cord-015021-pol2qm74 2641 22 can can MD cord-015021-pol2qm74 2641 23 be be VB cord-015021-pol2qm74 2641 24 attribuated attribuate VBN cord-015021-pol2qm74 2641 25 in in IN cord-015021-pol2qm74 2641 26 large large JJ cord-015021-pol2qm74 2641 27 part part NN cord-015021-pol2qm74 2641 28 to to IN cord-015021-pol2qm74 2641 29 a a DT cord-015021-pol2qm74 2641 30 protection protection NN cord-015021-pol2qm74 2641 31 of of IN cord-015021-pol2qm74 2641 32 NO no DT cord-015021-pol2qm74 2641 33 during during IN cord-015021-pol2qm74 2641 34 reperfusion reperfusion NN cord-015021-pol2qm74 2641 35 . . . cord-015021-pol2qm74 2642 1 Nitric nitric NN cord-015021-pol2qm74 2642 2 oxide oxide NN cord-015021-pol2qm74 2642 3 ( ( -LRB- cord-015021-pol2qm74 2642 4 NO no RB cord-015021-pol2qm74 2642 5 ) ) -RRB- cord-015021-pol2qm74 2642 6 reduces reduce VBZ cord-015021-pol2qm74 2642 7 pulmonary pulmonary JJ cord-015021-pol2qm74 2642 8 vascular vascular JJ cord-015021-pol2qm74 2642 9 resistance resistance NN cord-015021-pol2qm74 2642 10 and and CC cord-015021-pol2qm74 2642 11 increases increase VBZ cord-015021-pol2qm74 2642 12 oxygenation oxygenation NN cord-015021-pol2qm74 2642 13 by by IN cord-015021-pol2qm74 2642 14 inhalation inhalation NN cord-015021-pol2qm74 2642 15 in in IN cord-015021-pol2qm74 2642 16 ARDS ARDS NNP cord-015021-pol2qm74 2642 17 patients patient NNS cord-015021-pol2qm74 2642 18 [ [ -LRB- cord-015021-pol2qm74 2642 19 1 1 CD cord-015021-pol2qm74 2642 20 ] ] -RRB- cord-015021-pol2qm74 2642 21 . . . cord-015021-pol2qm74 2643 1 Animal animal NN cord-015021-pol2qm74 2643 2 studies study NNS cord-015021-pol2qm74 2643 3 on on IN cord-015021-pol2qm74 2643 4 the the DT cord-015021-pol2qm74 2643 5 endogeneous endogeneous JJ cord-015021-pol2qm74 2643 6 NO no DT cord-015021-pol2qm74 2643 7 production production NN cord-015021-pol2qm74 2643 8 proved prove VBD cord-015021-pol2qm74 2643 9 that that IN cord-015021-pol2qm74 2643 10 NO no DT cord-015021-pol2qm74 2643 11 is be VBZ cord-015021-pol2qm74 2643 12 exhaled exhale VBN cord-015021-pol2qm74 2643 13 after after IN cord-015021-pol2qm74 2643 14 synthesis synthesis NN cord-015021-pol2qm74 2643 15 in in IN cord-015021-pol2qm74 2643 16 the the DT cord-015021-pol2qm74 2643 17 respiratory respiratory JJ cord-015021-pol2qm74 2643 18 tract tract NN cord-015021-pol2qm74 2643 19 [ [ -LRB- cord-015021-pol2qm74 2643 20 2 2 CD cord-015021-pol2qm74 2643 21 ] ] -RRB- cord-015021-pol2qm74 2643 22 . . . cord-015021-pol2qm74 2644 1 With with IN cord-015021-pol2qm74 2644 2 approval approval NN cord-015021-pol2qm74 2644 3 by by IN cord-015021-pol2qm74 2644 4 the the DT cord-015021-pol2qm74 2644 5 hospital hospital NN cord-015021-pol2qm74 2644 6 ethics ethic NNS cord-015021-pol2qm74 2644 7 committee committee NNP cord-015021-pol2qm74 2644 8 , , , cord-015021-pol2qm74 2644 9 we -PRON- PRP cord-015021-pol2qm74 2644 10 studied study VBD cord-015021-pol2qm74 2644 11 healthy healthy JJ cord-015021-pol2qm74 2644 12 volunteers volunteer NNS cord-015021-pol2qm74 2644 13 and and CC cord-015021-pol2qm74 2644 14 ventilated ventilate VBN cord-015021-pol2qm74 2644 15 patients patient NNS cord-015021-pol2qm74 2644 16 by by IN cord-015021-pol2qm74 2644 17 measurement measurement NN cord-015021-pol2qm74 2644 18 of of IN cord-015021-pol2qm74 2644 19 inand inand NN cord-015021-pol2qm74 2644 20 exhaled exhale VBN cord-015021-pol2qm74 2644 21 NO no RB cord-015021-pol2qm74 2644 22 by by IN cord-015021-pol2qm74 2644 23 NO no NN cord-015021-pol2qm74 2644 24 / / SYM cord-015021-pol2qm74 2644 25 NO2-chemiluminescence no2-chemiluminescence NN cord-015021-pol2qm74 2644 26 in in IN cord-015021-pol2qm74 2644 27 segments segment NNS cord-015021-pol2qm74 2644 28 of of IN cord-015021-pol2qm74 2644 29 the the DT cord-015021-pol2qm74 2644 30 upper upper JJ cord-015021-pol2qm74 2644 31 respiratory respiratory JJ cord-015021-pol2qm74 2644 32 tract tract NN cord-015021-pol2qm74 2644 33 . . . cord-015021-pol2qm74 2645 1 We -PRON- PRP cord-015021-pol2qm74 2645 2 found find VBD cord-015021-pol2qm74 2645 3 that that IN cord-015021-pol2qm74 2645 4 NO no NN cord-015021-pol2qm74 2645 5 is be VBZ cord-015021-pol2qm74 2645 6 synthesized synthesize VBN cord-015021-pol2qm74 2645 7 predominantly predominantly RB cord-015021-pol2qm74 2645 8 in in IN cord-015021-pol2qm74 2645 9 the the DT cord-015021-pol2qm74 2645 10 nose nose NN cord-015021-pol2qm74 2645 11 and and CC cord-015021-pol2qm74 2645 12 in in IN cord-015021-pol2qm74 2645 13 the the DT cord-015021-pol2qm74 2645 14 upper upper JJ cord-015021-pol2qm74 2645 15 nasopharynx nasopharynx NN cord-015021-pol2qm74 2645 16 , , , cord-015021-pol2qm74 2645 17 leading lead VBG cord-015021-pol2qm74 2645 18 to to IN cord-015021-pol2qm74 2645 19 inspiratory inspiratory JJ cord-015021-pol2qm74 2645 20 tracheal tracheal NN cord-015021-pol2qm74 2645 21 NO no DT cord-015021-pol2qm74 2645 22 concentrations concentration NNS cord-015021-pol2qm74 2645 23 of of IN cord-015021-pol2qm74 2645 24 0.07 0.07 CD cord-015021-pol2qm74 2645 25 - - HYPH cord-015021-pol2qm74 2645 26 0.13 0.13 CD cord-015021-pol2qm74 2645 27 parts part NNS cord-015021-pol2qm74 2645 28 per per IN cord-015021-pol2qm74 2645 29 million million CD cord-015021-pol2qm74 2645 30 in in IN cord-015021-pol2qm74 2645 31 non non JJ cord-015021-pol2qm74 2645 32 - - JJ cord-015021-pol2qm74 2645 33 smoking smoking JJ cord-015021-pol2qm74 2645 34 volunteers volunteer NNS cord-015021-pol2qm74 2645 35 ; ; : cord-015021-pol2qm74 2645 36 data datum NNS cord-015021-pol2qm74 2645 37 during during IN cord-015021-pol2qm74 2645 38 mask mask NN cord-015021-pol2qm74 2645 39 ventilation ventilation NN cord-015021-pol2qm74 2645 40 per per IN cord-015021-pol2qm74 2645 41 nose nose NN cord-015021-pol2qm74 2645 42 were be VBD cord-015021-pol2qm74 2645 43 as as IN cord-015021-pol2qm74 2645 44 follows follow VBZ cord-015021-pol2qm74 2645 45 : : : cord-015021-pol2qm74 2646 1 Non non JJ cord-015021-pol2qm74 2646 2 0.089 0.089 CD cord-015021-pol2qm74 2646 3 0.0422 0.0422 CD cord-015021-pol2qm74 2647 1 0.0721 0.0721 CD cord-015021-pol2qm74 2647 2 0.0311,2 0.0311,2 CD cord-015021-pol2qm74 2648 1 Parts part NNS cord-015021-pol2qm74 2648 2 per per IN cord-015021-pol2qm74 2648 3 million million CD cord-015021-pol2qm74 2648 4 ( ( -LRB- cord-015021-pol2qm74 2648 5 ppm ppm NN cord-015021-pol2qm74 2648 6 ) ) -RRB- cord-015021-pol2qm74 2649 1 NO no UH cord-015021-pol2qm74 2649 2 , , , cord-015021-pol2qm74 2649 3 mean mean UH cord-015021-pol2qm74 2649 4 , , , cord-015021-pol2qm74 2649 5 n n NN cord-015021-pol2qm74 2649 6 = = SYM cord-015021-pol2qm74 2649 7 10 10 CD cord-015021-pol2qm74 2649 8 ; ; : cord-015021-pol2qm74 2649 9 ~ ~ CD cord-015021-pol2qm74 2649 10 p p NN cord-015021-pol2qm74 2649 11 < < XX cord-015021-pol2qm74 2649 12 0.05 0.05 CD cord-015021-pol2qm74 2649 13 ( ( -LRB- cord-015021-pol2qm74 2649 14 t t NN cord-015021-pol2qm74 2649 15 - - HYPH cord-015021-pol2qm74 2649 16 test test NN cord-015021-pol2qm74 2649 17 ) ) -RRB- cord-015021-pol2qm74 2649 18 between between IN cord-015021-pol2qm74 2649 19 smokers smoker NNS cord-015021-pol2qm74 2649 20 and and CC cord-015021-pol2qm74 2649 21 non non NNS cord-015021-pol2qm74 2649 22 - - NNS cord-015021-pol2qm74 2649 23 smokers smoker NNS cord-015021-pol2qm74 2649 24 ; ; : cord-015021-pol2qm74 2649 25 2 2 CD cord-015021-pol2qm74 2649 26 p p NN cord-015021-pol2qm74 2649 27 < < XX cord-015021-pol2qm74 2649 28 0.05 0.05 CD cord-015021-pol2qm74 2649 29 ( ( -LRB- cord-015021-pol2qm74 2649 30 t t NN cord-015021-pol2qm74 2649 31 - - HYPH cord-015021-pol2qm74 2649 32 test test NN cord-015021-pol2qm74 2649 33 ) ) -RRB- cord-015021-pol2qm74 2649 34 between between IN cord-015021-pol2qm74 2649 35 in in IN cord-015021-pol2qm74 2649 36 - - HYPH cord-015021-pol2qm74 2649 37 and and CC cord-015021-pol2qm74 2649 38 expiration expiration NN cord-015021-pol2qm74 2649 39 . . . cord-015021-pol2qm74 2650 1 About about RB cord-015021-pol2qm74 2650 2 50 50 CD cord-015021-pol2qm74 2650 3 % % NN cord-015021-pol2qm74 2650 4 of of IN cord-015021-pol2qm74 2650 5 NO no DT cord-015021-pol2qm74 2650 6 is be VBZ cord-015021-pol2qm74 2650 7 resorbe.d resorbe.d NN cord-015021-pol2qm74 2650 8 by by IN cord-015021-pol2qm74 2650 9 the the DT cord-015021-pol2qm74 2650 10 lung lung NN cord-015021-pol2qm74 2650 11 , , , cord-015021-pol2qm74 2650 12 and and CC cord-015021-pol2qm74 2650 13 the the DT cord-015021-pol2qm74 2650 14 exhaled exhale VBN cord-015021-pol2qm74 2650 15 NO no NN cord-015021-pol2qm74 2650 16 -in -in IN cord-015021-pol2qm74 2650 17 contrast contrast NN cord-015021-pol2qm74 2650 18 to to IN cord-015021-pol2qm74 2650 19 former former JJ cord-015021-pol2qm74 2650 20 presumptions presumption NNS cord-015021-pol2qm74 2650 21 -is -is NFP cord-015021-pol2qm74 2650 22 the the DT cord-015021-pol2qm74 2650 23 remaining remain VBG cord-015021-pol2qm74 2650 24 part part NN cord-015021-pol2qm74 2650 25 of of IN cord-015021-pol2qm74 2651 1 the the DT cord-015021-pol2qm74 2651 2 autoinhaled autoinhaled JJ cord-015021-pol2qm74 2651 3 NO no NN cord-015021-pol2qm74 2651 4 . . . cord-015021-pol2qm74 2652 1 Intubated intubated JJ cord-015021-pol2qm74 2652 2 and and CC cord-015021-pol2qm74 2652 3 ventilated ventilate VBN cord-015021-pol2qm74 2652 4 patients patient NNS cord-015021-pol2qm74 2652 5 are be VBP cord-015021-pol2qm74 2652 6 deprived deprive VBN cord-015021-pol2qm74 2652 7 of of IN cord-015021-pol2qm74 2652 8 NO no DT cord-015021-pol2qm74 2652 9 autoinhalation autoinhalation NN cord-015021-pol2qm74 2652 10 , , , cord-015021-pol2qm74 2652 11 and and CC cord-015021-pol2qm74 2652 12 the the DT cord-015021-pol2qm74 2652 13 exhaled exhaled JJ cord-015021-pol2qm74 2652 14 NO no NN cord-015021-pol2qm74 2652 15 in in IN cord-015021-pol2qm74 2652 16 the the DT cord-015021-pol2qm74 2652 17 trachea trachea NN cord-015021-pol2qm74 2652 18 decreases decrease VBZ cord-015021-pol2qm74 2652 19 more more JJR cord-015021-pol2qm74 2652 20 than than IN cord-015021-pol2qm74 2652 21 95 95 CD cord-015021-pol2qm74 2652 22 % % NN cord-015021-pol2qm74 2652 23 { { -LRB- cord-015021-pol2qm74 2652 24 O.043 O.043 NNP cord-015021-pol2qm74 2652 25 ppm ppm NN cord-015021-pol2qm74 2652 26 before before IN cord-015021-pol2qm74 2652 27 intubation intubation NN cord-015021-pol2qm74 2652 28 vs. vs. CC cord-015021-pol2qm74 2652 29 0.003 0.003 CD cord-015021-pol2qm74 2652 30 ppm ppm NN cord-015021-pol2qm74 2652 31 after after IN cord-015021-pol2qm74 2652 32 intubation intubation NN cord-015021-pol2qm74 2652 33 , , , cord-015021-pol2qm74 2652 34 ~ ~ NFP cord-015021-pol2qm74 2652 35 , , , cord-015021-pol2qm74 2652 36 < < XX cord-015021-pol2qm74 2652 37 0.01 0.01 CD cord-015021-pol2qm74 2652 38 ) ) -RRB- cord-015021-pol2qm74 2652 39 , , , cord-015021-pol2qm74 2652 40 whereas whereas IN cord-015021-pol2qm74 2652 41 the the DT cord-015021-pol2qm74 2652 42 nasal nasal NN cord-015021-pol2qm74 2652 43 NO no DT cord-015021-pol2qm74 2652 44 concentration concentration NN cord-015021-pol2qm74 2652 45 increases increase NNS cord-015021-pol2qm74 2652 46 by by IN cord-015021-pol2qm74 2652 47 cumulation cumulation NN cord-015021-pol2qm74 2652 48 . . . cord-015021-pol2qm74 2653 1 Hence hence RB cord-015021-pol2qm74 2653 2 , , , cord-015021-pol2qm74 2653 3 low low JJ cord-015021-pol2qm74 2653 4 - - HYPH cord-015021-pol2qm74 2653 5 dose dose NN cord-015021-pol2qm74 2653 6 NO no DT cord-015021-pol2qm74 2653 7 inhalation inhalation NN cord-015021-pol2qm74 2653 8 in in IN cord-015021-pol2qm74 2653 9 ARDS ARDS NNP cord-015021-pol2qm74 2653 10 patients patient NNS cord-015021-pol2qm74 2653 11 might may MD cord-015021-pol2qm74 2653 12 be be VB cord-015021-pol2qm74 2653 13 considered consider VBN cord-015021-pol2qm74 2653 14 as as IN cord-015021-pol2qm74 2653 15 a a DT cord-015021-pol2qm74 2653 16 NO no DT cord-015021-pol2qm74 2653 17 replacement replacement NN cord-015021-pol2qm74 2653 18 , , , cord-015021-pol2qm74 2653 19 especially especially RB cord-015021-pol2qm74 2653 20 since since IN cord-015021-pol2qm74 2653 21 the the DT cord-015021-pol2qm74 2653 22 tracheal tracheal NN cord-015021-pol2qm74 2654 1 NO no DT cord-015021-pol2qm74 2654 2 concentrations concentration NNS cord-015021-pol2qm74 2654 3 we -PRON- PRP cord-015021-pol2qm74 2654 4 measured measure VBD cord-015021-pol2qm74 2654 5 in in IN cord-015021-pol2qm74 2654 6 volunteers volunteer NNS cord-015021-pol2qm74 2654 7 are be VBP cord-015021-pol2qm74 2654 8 similar similar JJ cord-015021-pol2qm74 2654 9 to to IN cord-015021-pol2qm74 2654 10 those those DT cord-015021-pol2qm74 2654 11 which which WDT cord-015021-pol2qm74 2654 12 could could MD cord-015021-pol2qm74 2654 13 be be VB cord-015021-pol2qm74 2654 14 demonstrated demonstrate VBN cord-015021-pol2qm74 2654 15 to to TO cord-015021-pol2qm74 2654 16 be be VB cord-015021-pol2qm74 2654 17 effective effective JJ cord-015021-pol2qm74 2654 18 for for IN cord-015021-pol2qm74 2654 19 ARDS ARDS NNP cord-015021-pol2qm74 2654 20 in in IN cord-015021-pol2qm74 2654 21 former former JJ cord-015021-pol2qm74 2654 22 studies study NNS cord-015021-pol2qm74 2654 23 [ [ -LRB- cord-015021-pol2qm74 2654 24 3 3 CD cord-015021-pol2qm74 2654 25 ] ] -RRB- cord-015021-pol2qm74 2654 26 . . . cord-015021-pol2qm74 2655 1 The the DT cord-015021-pol2qm74 2655 2 data datum NNS cord-015021-pol2qm74 2655 3 demonstrate demonstrate VBP cord-015021-pol2qm74 2655 4 that that IN cord-015021-pol2qm74 2655 5 NO no NN cord-015021-pol2qm74 2655 6 is be VBZ cord-015021-pol2qm74 2655 7 synthesized synthesize VBN cord-015021-pol2qm74 2655 8 in in IN cord-015021-pol2qm74 2655 9 the the DT cord-015021-pol2qm74 2655 10 nose nose NN cord-015021-pol2qm74 2655 11 , , , cord-015021-pol2qm74 2655 12 and and CC cord-015021-pol2qm74 2655 13 inhaled inhale VBN cord-015021-pol2qm74 2655 14 and and CC cord-015021-pol2qm74 2655 15 resorbed resorb VBN cord-015021-pol2qm74 2655 16 by by IN cord-015021-pol2qm74 2655 17 the the DT cord-015021-pol2qm74 2655 18 lung lung NN cord-015021-pol2qm74 2655 19 . . . cord-015021-pol2qm74 2656 1 This this DT cord-015021-pol2qm74 2656 2 phenomenon phenomenon NN cord-015021-pol2qm74 2656 3 of of IN cord-015021-pol2qm74 2656 4 NO no DT cord-015021-pol2qm74 2656 5 autoinhalation autoinhalation NN cord-015021-pol2qm74 2656 6 , , , cord-015021-pol2qm74 2656 7 which which WDT cord-015021-pol2qm74 2656 8 is be VBZ cord-015021-pol2qm74 2656 9 reduced reduce VBN cord-015021-pol2qm74 2656 10 in in IN cord-015021-pol2qm74 2656 11 smokers smoker NNS cord-015021-pol2qm74 2656 12 and and CC cord-015021-pol2qm74 2656 13 in in IN cord-015021-pol2qm74 2656 14 ventilated ventilate VBN cord-015021-pol2qm74 2656 15 patients patient NNS cord-015021-pol2qm74 2656 16 , , , cord-015021-pol2qm74 2656 17 does do VBZ cord-015021-pol2qm74 2656 18 possibly possibly RB cord-015021-pol2qm74 2656 19 contribute contribute VB cord-015021-pol2qm74 2656 20 to to IN cord-015021-pol2qm74 2656 21 the the DT cord-015021-pol2qm74 2656 22 regulation regulation NN cord-015021-pol2qm74 2656 23 of of IN cord-015021-pol2qm74 2656 24 the the DT cord-015021-pol2qm74 2656 25 ventilation ventilation NN cord-015021-pol2qm74 2656 26 - - HYPH cord-015021-pol2qm74 2656 27 perfusion perfusion NN cord-015021-pol2qm74 2656 28 ratio ratio NN cord-015021-pol2qm74 2656 29 in in IN cord-015021-pol2qm74 2656 30 the the DT cord-015021-pol2qm74 2656 31 lung lung NN cord-015021-pol2qm74 2656 32 . . . cord-015021-pol2qm74 2656 33 _SP cord-015021-pol2qm74 2657 1 Kikuchi Kikuchi NNP cord-015021-pol2qm74 2657 2 1 1 CD cord-015021-pol2qm74 2657 3 , , , cord-015021-pol2qm74 2657 4 Yoshihiro Yoshihiro NNP cord-015021-pol2qm74 2657 5 Inoue Inoue NNP cord-015021-pol2qm74 2657 6 1 1 CD cord-015021-pol2qm74 2657 7 , , , cord-015021-pol2qm74 2657 8 Masao Masao NNP cord-015021-pol2qm74 2657 9 Yoshida Yoshida NNP cord-015021-pol2qm74 2657 10 2 2 CD cord-015021-pol2qm74 2657 11 1 1 CD cord-015021-pol2qm74 2657 12 Critical Critical NNP cord-015021-pol2qm74 2657 13 Care Care NNP cord-015021-pol2qm74 2657 14 and and CC cord-015021-pol2qm74 2657 15 Emergency Emergency NNP cord-015021-pol2qm74 2657 16 Center Center NNP cord-015021-pol2qm74 2657 17 , , , cord-015021-pol2qm74 2657 18 and and CC cord-015021-pol2qm74 2657 19 2Department 2department CD cord-015021-pol2qm74 2657 20 of of IN cord-015021-pol2qm74 2657 21 Bacteriology Bacteriology NNP cord-015021-pol2qm74 2657 22 , , , cord-015021-pol2qm74 2657 23 Iwate Iwate NNP cord-015021-pol2qm74 2657 24 Medical Medical NNP cord-015021-pol2qm74 2657 25 University University NNP cord-015021-pol2qm74 2657 26 . . . cord-015021-pol2qm74 2658 1 Nitric nitric NN cord-015021-pol2qm74 2658 2 oxide oxide NN cord-015021-pol2qm74 2658 3 ( ( -LRB- cord-015021-pol2qm74 2658 4 NO no UH cord-015021-pol2qm74 2658 5 ) ) -RRB- cord-015021-pol2qm74 2658 6 is be VBZ cord-015021-pol2qm74 2658 7 produced produce VBN cord-015021-pol2qm74 2658 8 by by IN cord-015021-pol2qm74 2658 9 macrophages macrophage NNS cord-015021-pol2qm74 2658 10 and and CC cord-015021-pol2qm74 2658 11 vascular vascular JJ cord-015021-pol2qm74 2658 12 endothelial endothelial JJ cord-015021-pol2qm74 2658 13 cells cell NNS cord-015021-pol2qm74 2658 14 . . . cord-015021-pol2qm74 2659 1 It -PRON- PRP cord-015021-pol2qm74 2659 2 is be VBZ cord-015021-pol2qm74 2659 3 thought think VBN cord-015021-pol2qm74 2659 4 to to TO cord-015021-pol2qm74 2659 5 be be VB cord-015021-pol2qm74 2659 6 the the DT cord-015021-pol2qm74 2659 7 true true JJ cord-015021-pol2qm74 2659 8 form form NN cord-015021-pol2qm74 2659 9 of of IN cord-015021-pol2qm74 2659 10 endotheliumderived endotheliumderived JJ cord-015021-pol2qm74 2659 11 relaxing relaxing NN cord-015021-pol2qm74 2659 12 factor factor NN cord-015021-pol2qm74 2659 13 , , , cord-015021-pol2qm74 2659 14 and and CC cord-015021-pol2qm74 2659 15 to to TO cord-015021-pol2qm74 2659 16 be be VB cord-015021-pol2qm74 2659 17 involved involve VBN cord-015021-pol2qm74 2659 18 in in IN cord-015021-pol2qm74 2659 19 the the DT cord-015021-pol2qm74 2659 20 fall fall NN cord-015021-pol2qm74 2659 21 of of IN cord-015021-pol2qm74 2659 22 blood blood NN cord-015021-pol2qm74 2659 23 pressure pressure NN cord-015021-pol2qm74 2659 24 during during IN cord-015021-pol2qm74 2659 25 septic septic JJ cord-015021-pol2qm74 2659 26 shock shock NN cord-015021-pol2qm74 2659 27 . . . cord-015021-pol2qm74 2660 1 We -PRON- PRP cord-015021-pol2qm74 2660 2 have have VBP cord-015021-pol2qm74 2660 3 reported report VBN cord-015021-pol2qm74 2660 4 previously previously RB cord-015021-pol2qm74 2660 5 that that IN cord-015021-pol2qm74 2660 6 endotoxin endotoxin NN cord-015021-pol2qm74 2660 7 ( ( -LRB- cord-015021-pol2qm74 2660 8 LPS LPS NNP cord-015021-pol2qm74 2660 9 ) ) -RRB- cord-015021-pol2qm74 2660 10 , , , cord-015021-pol2qm74 2660 11 TNF TNF NNP cord-015021-pol2qm74 2660 12 - - HYPH cord-015021-pol2qm74 2660 13 c~ c~ NNP cord-015021-pol2qm74 2660 14 and and CC cord-015021-pol2qm74 2660 15 IL-2 IL-2 NNP cord-015021-pol2qm74 2660 16 contribute contribute VBP cord-015021-pol2qm74 2660 17 to to IN cord-015021-pol2qm74 2660 18 the the DT cord-015021-pol2qm74 2660 19 occurrence occurrence NN cord-015021-pol2qm74 2660 20 of of IN cord-015021-pol2qm74 2660 21 septic septic JJ cord-015021-pol2qm74 2660 22 shock shock NN cord-015021-pol2qm74 2660 23 ( ( -LRB- cord-015021-pol2qm74 2660 24 Circ Circ NNP cord-015021-pol2qm74 2660 25 Shock Shock NNP cord-015021-pol2qm74 2660 26 38:264 38:264 CD cord-015021-pol2qm74 2660 27 ; ; : cord-015021-pol2qm74 2660 28 . . . cord-015021-pol2qm74 2661 1 The the DT cord-015021-pol2qm74 2661 2 present present JJ cord-015021-pol2qm74 2661 3 study study NN cord-015021-pol2qm74 2661 4 investigated investigate VBD cord-015021-pol2qm74 2661 5 the the DT cord-015021-pol2qm74 2661 6 in in FW cord-015021-pol2qm74 2661 7 vitro vitro FW cord-015021-pol2qm74 2661 8 effects effect NNS cord-015021-pol2qm74 2661 9 of of IN cord-015021-pol2qm74 2661 10 LPS LPS NNP cord-015021-pol2qm74 2661 11 , , , cord-015021-pol2qm74 2661 12 TNF TNF NNP cord-015021-pol2qm74 2661 13 - - HYPH cord-015021-pol2qm74 2661 14 o~ o~ NNP cord-015021-pol2qm74 2661 15 , , , cord-015021-pol2qm74 2661 16 IL-2 IL-2 NNP cord-015021-pol2qm74 2661 17 and and CC cord-015021-pol2qm74 2661 18 IFN-'I ifn-'i NN cord-015021-pol2qm74 2661 19 on on IN cord-015021-pol2qm74 2661 20 the the DT cord-015021-pol2qm74 2661 21 production production NN cord-015021-pol2qm74 2661 22 of of IN cord-015021-pol2qm74 2661 23 NO no NN cord-015021-pol2qm74 2661 24 by by IN cord-015021-pol2qm74 2661 25 macrophages macrophage NNS cord-015021-pol2qm74 2661 26 . . . cord-015021-pol2qm74 2662 1 Peritoneal peritoneal JJ cord-015021-pol2qm74 2662 2 macrophages macrophage NNS cord-015021-pol2qm74 2662 3 were be VBD cord-015021-pol2qm74 2662 4 cultured culture VBN cord-015021-pol2qm74 2662 5 with with IN cord-015021-pol2qm74 2662 6 LPS LPS NNP cord-015021-pol2qm74 2662 7 , , , cord-015021-pol2qm74 2662 8 IL-2 IL-2 NNP cord-015021-pol2qm74 2662 9 , , , cord-015021-pol2qm74 2662 10 TNF-~ TNF-~ NNP cord-015021-pol2qm74 2662 11 and and CC cord-015021-pol2qm74 2662 12 IFN-¥. ifn-¥. NN cord-015021-pol2qm74 2663 1 In in IN cord-015021-pol2qm74 2663 2 culture culture NN cord-015021-pol2qm74 2663 3 with with IN cord-015021-pol2qm74 2663 4 LPS LPS NNP cord-015021-pol2qm74 2663 5 , , , cord-015021-pol2qm74 2663 6 NO NO NNP cord-015021-pol2qm74 2663 7 was be VBD cord-015021-pol2qm74 2663 8 produced produce VBN cord-015021-pol2qm74 2663 9 in in IN cord-015021-pol2qm74 2663 10 a a DT cord-015021-pol2qm74 2663 11 dose dose NN cord-015021-pol2qm74 2663 12 - - HYPH cord-015021-pol2qm74 2663 13 dependent dependent JJ cord-015021-pol2qm74 2663 14 manner manner NN cord-015021-pol2qm74 2663 15 , , , cord-015021-pol2qm74 2663 16 and and CC cord-015021-pol2qm74 2663 17 the the DT cord-015021-pol2qm74 2663 18 production production NN cord-015021-pol2qm74 2663 19 was be VBD cord-015021-pol2qm74 2663 20 suppressed suppress VBN cord-015021-pol2qm74 2663 21 by by IN cord-015021-pol2qm74 2663 22 a a DT cord-015021-pol2qm74 2663 23 NO no JJ cord-015021-pol2qm74 2663 24 production production NN cord-015021-pol2qm74 2663 25 inhibitor inhibitor NN cord-015021-pol2qm74 2663 26 , , , cord-015021-pol2qm74 2663 27 L L NNP cord-015021-pol2qm74 2663 28 - - HYPH cord-015021-pol2qm74 2663 29 NMMA NMMA NNP cord-015021-pol2qm74 2663 30 . . . cord-015021-pol2qm74 2664 1 IFN IFN NNP cord-015021-pol2qm74 2664 2 - - HYPH cord-015021-pol2qm74 2664 3 Y Y NNP cord-015021-pol2qm74 2664 4 , , , cord-015021-pol2qm74 2664 5 IL-2 IL-2 NNP cord-015021-pol2qm74 2664 6 and and CC cord-015021-pol2qm74 2664 7 TNF TNF NNP cord-015021-pol2qm74 2664 8 - - HYPH cord-015021-pol2qm74 2664 9 c~ c~ NNP cord-015021-pol2qm74 2664 10 used use VBN cord-015021-pol2qm74 2664 11 alone alone RB cord-015021-pol2qm74 2664 12 did do VBD cord-015021-pol2qm74 2664 13 not not RB cord-015021-pol2qm74 2664 14 promote promote VB cord-015021-pol2qm74 2664 15 the the DT cord-015021-pol2qm74 2664 16 production production NN cord-015021-pol2qm74 2664 17 of of IN cord-015021-pol2qm74 2664 18 NO no NN cord-015021-pol2qm74 2664 19 , , , cord-015021-pol2qm74 2664 20 but but CC cord-015021-pol2qm74 2664 21 helped help VBD cord-015021-pol2qm74 2664 22 LPS LPS NNP cord-015021-pol2qm74 2664 23 to to TO cord-015021-pol2qm74 2664 24 facilitate facilitate VB cord-015021-pol2qm74 2664 25 NO no DT cord-015021-pol2qm74 2664 26 production production NN cord-015021-pol2qm74 2664 27 . . . cord-015021-pol2qm74 2665 1 A a DT cord-015021-pol2qm74 2665 2 combination combination NN cord-015021-pol2qm74 2665 3 of of IN cord-015021-pol2qm74 2665 4 IL-2 IL-2 NNP cord-015021-pol2qm74 2665 5 and and CC cord-015021-pol2qm74 2665 6 TNF TNF NNP cord-015021-pol2qm74 2665 7 - - HYPH cord-015021-pol2qm74 2665 8 c c NNP cord-015021-pol2qm74 2665 9 ( ( -LRB- cord-015021-pol2qm74 2665 10 enhanced enhanced JJ cord-015021-pol2qm74 2665 11 LPS LPS NNP cord-015021-pol2qm74 2665 12 - - HYPH cord-015021-pol2qm74 2665 13 facilitated facilitate VBN cord-015021-pol2qm74 2665 14 NO no DT cord-015021-pol2qm74 2665 15 production production NN cord-015021-pol2qm74 2665 16 to to IN cord-015021-pol2qm74 2665 17 a a DT cord-015021-pol2qm74 2665 18 greater great JJR cord-015021-pol2qm74 2665 19 extent extent NN cord-015021-pol2qm74 2665 20 than than IN cord-015021-pol2qm74 2666 1 IL-2 IL-2 NNP cord-015021-pol2qm74 2666 2 or or CC cord-015021-pol2qm74 2666 3 TNF TNF NNP cord-015021-pol2qm74 2666 4 - - : cord-015021-pol2qm74 2666 5 c~ c~ NNP cord-015021-pol2qm74 2666 6 alone alone RB cord-015021-pol2qm74 2666 7 . . . cord-015021-pol2qm74 2667 1 The the DT cord-015021-pol2qm74 2667 2 above above JJ cord-015021-pol2qm74 2667 3 results result NNS cord-015021-pol2qm74 2667 4 suggest suggest VBP cord-015021-pol2qm74 2667 5 that that IN cord-015021-pol2qm74 2667 6 these these DT cord-015021-pol2qm74 2667 7 cytokines cytokine NNS cord-015021-pol2qm74 2667 8 are be VBP cord-015021-pol2qm74 2667 9 involved involve VBN cord-015021-pol2qm74 2667 10 in in IN cord-015021-pol2qm74 2667 11 endotoxin endotoxin NN cord-015021-pol2qm74 2667 12 shock shock NN cord-015021-pol2qm74 2667 13 through through IN cord-015021-pol2qm74 2667 14 the the DT cord-015021-pol2qm74 2667 15 mechanisms mechanism NNS cord-015021-pol2qm74 2667 16 that that WDT cord-015021-pol2qm74 2667 17 facilitate facilitate VBP cord-015021-pol2qm74 2667 18 NO no DT cord-015021-pol2qm74 2667 19 production production NN cord-015021-pol2qm74 2667 20 . . . cord-015021-pol2qm74 2668 1 19 19 CD cord-015021-pol2qm74 2668 2 - - SYM cord-015021-pol2qm74 2668 3 1 1 CD cord-015021-pol2qm74 2668 4 Uchimaru Uchimaru NNP cord-015021-pol2qm74 2668 5 , , , cord-015021-pol2qm74 2668 6 Morioka Morioka NNP cord-015021-pol2qm74 2668 7 020 020 CD cord-015021-pol2qm74 2668 8 . . . cord-015021-pol2qm74 2669 1 Japan Japan NNP cord-015021-pol2qm74 2669 2 . . . cord-015021-pol2qm74 2670 1 T. T. NNP cord-015021-pol2qm74 2670 2 Yolk yolk NN cord-015021-pol2qm74 2670 3 1,2 1,2 CD cord-015021-pol2qm74 2670 4 , , , cord-015021-pol2qm74 2670 5 I. I. NNP cord-015021-pol2qm74 2670 6 Ioannidis Ioannidis NNP cord-015021-pol2qm74 2670 7 1 1 CD cord-015021-pol2qm74 2670 8 , , , cord-015021-pol2qm74 2670 9 W.J. W.J. NNP cord-015021-pol2qm74 2670 10 Kox Kox NNP cord-015021-pol2qm74 2670 11 2 2 CD cord-015021-pol2qm74 2670 12 and and CC cord-015021-pol2qm74 2671 1 H. H. NNP cord-015021-pol2qm74 2671 2 de de NNP cord-015021-pol2qm74 2671 3 Groot Groot NNP cord-015021-pol2qm74 2671 4 1 1 CD cord-015021-pol2qm74 2671 5 Objectives Objectives NNPS cord-015021-pol2qm74 2671 6 : : : cord-015021-pol2qm74 2672 1 Nitric nitric NN cord-015021-pol2qm74 2672 2 Oxide oxide NN cord-015021-pol2qm74 2672 3 ( ( -LRB- cord-015021-pol2qm74 2672 4 NO no UH cord-015021-pol2qm74 2672 5 . . . cord-015021-pol2qm74 2672 6 ) ) -RRB- cord-015021-pol2qm74 2672 7 is be VBZ cord-015021-pol2qm74 2672 8 known know VBN cord-015021-pol2qm74 2672 9 to to TO cord-015021-pol2qm74 2672 10 play play VB cord-015021-pol2qm74 2672 11 an an DT cord-015021-pol2qm74 2672 12 important important JJ cord-015021-pol2qm74 2672 13 role role NN cord-015021-pol2qm74 2672 14 in in IN cord-015021-pol2qm74 2672 15 neurotransmission neurotransmission NN cord-015021-pol2qm74 2672 16 , , , cord-015021-pol2qm74 2672 17 vasoregulation vasoregulation NN cord-015021-pol2qm74 2672 18 , , , cord-015021-pol2qm74 2672 19 and and CC cord-015021-pol2qm74 2672 20 bactericidal bactericidal JJ cord-015021-pol2qm74 2672 21 as as RB cord-015021-pol2qm74 2672 22 well well RB cord-015021-pol2qm74 2672 23 as as IN cord-015021-pol2qm74 2672 24 tumoricidal tumoricidal NNP cord-015021-pol2qm74 2672 25 cellular cellular JJ cord-015021-pol2qm74 2672 26 defense defense NN cord-015021-pol2qm74 2672 27 systems system NNS cord-015021-pol2qm74 2672 28 . . . cord-015021-pol2qm74 2673 1 By by IN cord-015021-pol2qm74 2673 2 means mean NNS cord-015021-pol2qm74 2673 3 of of IN cord-015021-pol2qm74 2673 4 NO no RB cord-015021-pol2qm74 2673 5 - - HYPH cord-015021-pol2qm74 2673 6 donating donate VBG cord-015021-pol2qm74 2673 7 agents agent NNS cord-015021-pol2qm74 2673 8 we -PRON- PRP cord-015021-pol2qm74 2673 9 studied study VBD cord-015021-pol2qm74 2673 10 the the DT cord-015021-pol2qm74 2673 11 mechanism mechanism NN cord-015021-pol2qm74 2673 12 of of IN cord-015021-pol2qm74 2673 13 NO no RB cord-015021-pol2qm74 2673 14 - - HYPH cord-015021-pol2qm74 2673 15 mediated mediate VBN cord-015021-pol2qm74 2673 16 cytotoxicity cytotoxicity NN cord-015021-pol2qm74 2673 17 against against IN cord-015021-pol2qm74 2673 18 rat rat NN cord-015021-pol2qm74 2673 19 liver liver NN cord-015021-pol2qm74 2673 20 microvascular microvascular JJ cord-015021-pol2qm74 2673 21 endothelial endothelial JJ cord-015021-pol2qm74 2673 22 cells cell NNS cord-015021-pol2qm74 2673 23 . . . cord-015021-pol2qm74 2674 1 Materials material NNS cord-015021-pol2qm74 2674 2 and and CC cord-015021-pol2qm74 2674 3 methods method NNS cord-015021-pol2qm74 2674 4 : : : cord-015021-pol2qm74 2674 5 3-morphoiinosydnonimine 3-morphoiinosydnonimine CD cord-015021-pol2qm74 2674 6 - - HYPH cord-015021-pol2qm74 2674 7 N N NNP cord-015021-pol2qm74 2674 8 - - HYPH cord-015021-pol2qm74 2674 9 ethylcarbamide ethylcarbamide NN cord-015021-pol2qm74 2674 10 ( ( -LRB- cord-015021-pol2qm74 2674 11 SIN sin NN cord-015021-pol2qm74 2674 12 - - HYPH cord-015021-pol2qm74 2674 13 l l NN cord-015021-pol2qm74 2674 14 ) ) -RRB- cord-015021-pol2qm74 2674 15 and and CC cord-015021-pol2qm74 2674 16 sodium sodium NN cord-015021-pol2qm74 2674 17 nitroprusside nitroprusside NN cord-015021-pol2qm74 2674 18 ( ( -LRB- cord-015021-pol2qm74 2674 19 SNP SNP NNP cord-015021-pol2qm74 2674 20 ) ) -RRB- cord-015021-pol2qm74 2674 21 were be VBD cord-015021-pol2qm74 2674 22 used use VBN cord-015021-pol2qm74 2674 23 as as IN cord-015021-pol2qm74 2674 24 NO no RB cord-015021-pol2qm74 2674 25 . . . cord-015021-pol2qm74 2675 1 donators donator NNS cord-015021-pol2qm74 2675 2 , , , cord-015021-pol2qm74 2675 3 LDH LDH NNP cord-015021-pol2qm74 2675 4 release release NN cord-015021-pol2qm74 2675 5 and and CC cord-015021-pol2qm74 2675 6 trypan trypan NNP cord-015021-pol2qm74 2675 7 blue blue JJ cord-015021-pol2qm74 2675 8 exclusion exclusion NN cord-015021-pol2qm74 2675 9 were be VBD cord-015021-pol2qm74 2675 10 applied apply VBN cord-015021-pol2qm74 2675 11 to to TO cord-015021-pol2qm74 2675 12 indicate indicate VB cord-015021-pol2qm74 2675 13 cell cell NN cord-015021-pol2qm74 2675 14 viability viability NN cord-015021-pol2qm74 2675 15 . . . cord-015021-pol2qm74 2676 1 Results result NNS cord-015021-pol2qm74 2676 2 : : : cord-015021-pol2qm74 2676 3 SIN-1 SIN-1 NNP cord-015021-pol2qm74 2676 4 ( ( -LRB- cord-015021-pol2qm74 2676 5 5mM 5mm CD cord-015021-pol2qm74 2676 6 ) ) -RRB- cord-015021-pol2qm74 2676 7 , , , cord-015021-pol2qm74 2676 8 which which WDT cord-015021-pol2qm74 2676 9 releases release VBZ cord-015021-pol2qm74 2676 10 both both CC cord-015021-pol2qm74 2676 11 NO no NN cord-015021-pol2qm74 2676 12 . . . cord-015021-pol2qm74 2676 13 and and CC cord-015021-pol2qm74 2676 14 O2- o2- UH cord-015021-pol2qm74 2676 15 . . . cord-015021-pol2qm74 2676 16 , , , cord-015021-pol2qm74 2676 17 caused cause VBD cord-015021-pol2qm74 2676 18 a a DT cord-015021-pol2qm74 2676 19 time time NN cord-015021-pol2qm74 2676 20 - - HYPH cord-015021-pol2qm74 2676 21 dependent dependent JJ cord-015021-pol2qm74 2676 22 cytoreduction cytoreduction NN cord-015021-pol2qm74 2676 23 of of IN cord-015021-pol2qm74 2676 24 60 60 CD cord-015021-pol2qm74 2676 25 % % NN cord-015021-pol2qm74 2676 26 and and CC cord-015021-pol2qm74 2676 27 80 80 CD cord-015021-pol2qm74 2676 28 % % NN cord-015021-pol2qm74 2676 29 after after IN cord-015021-pol2qm74 2676 30 3 3 CD cord-015021-pol2qm74 2676 31 and and CC cord-015021-pol2qm74 2676 32 6 6 CD cord-015021-pol2qm74 2676 33 hrs hrs NN cord-015021-pol2qm74 2676 34 , , , cord-015021-pol2qm74 2676 35 respectively respectively RB cord-015021-pol2qm74 2676 36 . . . cord-015021-pol2qm74 2677 1 This this DT cord-015021-pol2qm74 2677 2 effect effect NN cord-015021-pol2qm74 2677 3 was be VBD cord-015021-pol2qm74 2677 4 not not RB cord-015021-pol2qm74 2677 5 inhibited inhibit VBN cord-015021-pol2qm74 2677 6 by by IN cord-015021-pol2qm74 2677 7 superoxide superoxide NN cord-015021-pol2qm74 2677 8 dismutase dismutase NN cord-015021-pol2qm74 2677 9 ( ( -LRB- cord-015021-pol2qm74 2677 10 SOD SOD NNP cord-015021-pol2qm74 2677 11 ) ) -RRB- cord-015021-pol2qm74 2677 12 , , , cord-015021-pol2qm74 2677 13 which which WDT cord-015021-pol2qm74 2677 14 removes remove VBZ cord-015021-pol2qm74 2677 15 02 02 CD cord-015021-pol2qm74 2677 16 - - SYM cord-015021-pol2qm74 2677 17 -to -to JJS cord-015021-pol2qm74 2677 18 form form NN cord-015021-pol2qm74 2677 19 H202 h202 NN cord-015021-pol2qm74 2677 20 and and CC cord-015021-pol2qm74 2677 21 02 02 CD cord-015021-pol2qm74 2677 22 . . . cord-015021-pol2qm74 2678 1 In in IN cord-015021-pol2qm74 2678 2 contrast contrast NN cord-015021-pol2qm74 2678 3 , , , cord-015021-pol2qm74 2678 4 the the DT cord-015021-pol2qm74 2678 5 addition addition NN cord-015021-pol2qm74 2678 6 of of IN cord-015021-pol2qm74 2678 7 catalase catalase NN cord-015021-pol2qm74 2678 8 ( ( -LRB- cord-015021-pol2qm74 2678 9 CAT CAT NNP cord-015021-pol2qm74 2678 10 ) ) -RRB- cord-015021-pol2qm74 2678 11 , , , cord-015021-pol2qm74 2678 12 which which WDT cord-015021-pol2qm74 2678 13 removes remove VBZ cord-015021-pol2qm74 2678 14 H202 h202 NN cord-015021-pol2qm74 2678 15 to to TO cord-015021-pol2qm74 2678 16 form form VB cord-015021-pol2qm74 2678 17 H20 H20 NNP cord-015021-pol2qm74 2678 18 and and CC cord-015021-pol2qm74 2678 19 02 02 CD cord-015021-pol2qm74 2678 20 , , , cord-015021-pol2qm74 2678 21 diminished diminish VBD cord-015021-pol2qm74 2678 22 the the DT cord-015021-pol2qm74 2678 23 cytotoxic cytotoxic JJ cord-015021-pol2qm74 2678 24 effect effect NN cord-015021-pol2qm74 2678 25 ot ot NN cord-015021-pol2qm74 2678 26 SIN-1 SIN-1 NNP cord-015021-pol2qm74 2678 27 to to IN cord-015021-pol2qm74 2678 28 30 30 CD cord-015021-pol2qm74 2678 29 % % NN cord-015021-pol2qm74 2678 30 , , , cord-015021-pol2qm74 2678 31 equivalent equivalent JJ cord-015021-pol2qm74 2678 32 to to IN cord-015021-pol2qm74 2678 33 high high JJ cord-015021-pol2qm74 2678 34 concentrations concentration NNS cord-015021-pol2qm74 2678 35 of of IN cord-015021-pol2qm74 2678 36 SNP SNP NNP cord-015021-pol2qm74 2678 37 ( ( -LRB- cord-015021-pol2qm74 2678 38 20mM 20mm CD cord-015021-pol2qm74 2678 39 ) ) -RRB- cord-015021-pol2qm74 2678 40 , , , cord-015021-pol2qm74 2678 41 which which WDT cord-015021-pol2qm74 2678 42 solely solely RB cord-015021-pol2qm74 2678 43 releases release VBZ cord-015021-pol2qm74 2678 44 NO no DT cord-015021-pol2qm74 2678 45 .. .. . cord-015021-pol2qm74 2679 1 In in IN cord-015021-pol2qm74 2679 2 addition addition NN cord-015021-pol2qm74 2679 3 , , , cord-015021-pol2qm74 2679 4 the the DT cord-015021-pol2qm74 2679 5 amount amount NN cord-015021-pol2qm74 2679 6 of of IN cord-015021-pol2qm74 2679 7 H202 h202 NN cord-015021-pol2qm74 2679 8 formed form VBN cord-015021-pol2qm74 2679 9 by by IN cord-015021-pol2qm74 2679 10 5mM 5mm CD cord-015021-pol2qm74 2679 11 SIN-1 SIN-1 NNP cord-015021-pol2qm74 2679 12 equaled equal VBD cord-015021-pol2qm74 2679 13 the the DT cord-015021-pol2qm74 2679 14 amount amount NN cord-015021-pol2qm74 2679 15 ot ot NNP cord-015021-pol2qm74 2679 16 enzymaticany enzymaticany NNP cord-015021-pol2qm74 2679 17 produced produce VBD cord-015021-pol2qm74 2679 18 H202 h202 NN cord-015021-pol2qm74 2679 19 by by IN cord-015021-pol2qm74 2679 20 5mU 5mu CD cord-015021-pol2qm74 2679 21 / / SYM cord-015021-pol2qm74 2679 22 L l NN cord-015021-pol2qm74 2679 23 glucose glucose NN cord-015021-pol2qm74 2679 24 oxidase oxidase NN cord-015021-pol2qm74 2679 25 ( ( -LRB- cord-015021-pol2qm74 2679 26 GOD GOD NNP cord-015021-pol2qm74 2679 27 ) ) -RRB- cord-015021-pol2qm74 2679 28 . . . cord-015021-pol2qm74 2680 1 Whereas whereas IN cord-015021-pol2qm74 2680 2 GOD GOD NNP cord-015021-pol2qm74 2680 3 in in IN cord-015021-pol2qm74 2680 4 this this DT cord-015021-pol2qm74 2680 5 concentration concentration NN cord-015021-pol2qm74 2680 6 and and CC cord-015021-pol2qm74 2680 7 SNP SNP NNP cord-015021-pol2qm74 2680 8 in in IN cord-015021-pol2qm74 2680 9 low low JJ cord-015021-pol2qm74 2680 10 concentration concentration NN cord-015021-pol2qm74 2680 11 ( ( -LRB- cord-015021-pol2qm74 2680 12 5mM 5mm CD cord-015021-pol2qm74 2680 13 ) ) -RRB- cord-015021-pol2qm74 2680 14 alone alone RB cord-015021-pol2qm74 2680 15 were be VBD cord-015021-pol2qm74 2680 16 not not RB cord-015021-pol2qm74 2680 17 toxic toxic JJ cord-015021-pol2qm74 2680 18 to to IN cord-015021-pol2qm74 2680 19 endothelial endothelial JJ cord-015021-pol2qm74 2680 20 cells cell NNS cord-015021-pol2qm74 2680 21 , , , cord-015021-pol2qm74 2680 22 the the DT cord-015021-pol2qm74 2680 23 combination combination NN cord-015021-pol2qm74 2680 24 caused cause VBD cord-015021-pol2qm74 2680 25 an an DT cord-015021-pol2qm74 2680 26 80 80 CD cord-015021-pol2qm74 2680 27 % % NN cord-015021-pol2qm74 2680 28 reduction reduction NN cord-015021-pol2qm74 2680 29 of of IN cord-015021-pol2qm74 2680 30 viability viability NN cord-015021-pol2qm74 2680 31 , , , cord-015021-pol2qm74 2680 32 comparable comparable JJ cord-015021-pol2qm74 2680 33 to to IN cord-015021-pol2qm74 2680 34 the the DT cord-015021-pol2qm74 2680 35 effect effect NN cord-015021-pol2qm74 2680 36 observed observe VBN cord-015021-pol2qm74 2680 37 with with IN cord-015021-pol2qm74 2680 38 SIN-1 SIN-1 NNP cord-015021-pol2qm74 2680 39 ( ( -LRB- cord-015021-pol2qm74 2680 40 5mM 5mm CD cord-015021-pol2qm74 2680 41 ) ) -RRB- cord-015021-pol2qm74 2680 42 alone alone RB cord-015021-pol2qm74 2680 43 . . . cord-015021-pol2qm74 2681 1 Moreover moreover RB cord-015021-pol2qm74 2681 2 , , , cord-015021-pol2qm74 2681 3 toxicity toxicity NN cord-015021-pol2qm74 2681 4 mediated mediate VBN cord-015021-pol2qm74 2681 5 by by IN cord-015021-pol2qm74 2681 6 high high JJ cord-015021-pol2qm74 2681 7 concentrations concentration NNS cord-015021-pol2qm74 2681 8 of of IN cord-015021-pol2qm74 2681 9 SNP SNP NNP cord-015021-pol2qm74 2681 10 ( ( -LRB- cord-015021-pol2qm74 2681 11 20mM 20mm CD cord-015021-pol2qm74 2681 12 and and CC cord-015021-pol2qm74 2681 13 50raM 50ram CD cord-015021-pol2qm74 2681 14 ) ) -RRB- cord-015021-pol2qm74 2681 15 was be VBD cord-015021-pol2qm74 2681 16 reduced reduce VBN cord-015021-pol2qm74 2681 17 by by IN cord-015021-pol2qm74 2681 18 20 20 CD cord-015021-pol2qm74 2681 19 % % NN cord-015021-pol2qm74 2681 20 under under IN cord-015021-pol2qm74 2681 21 hypoxic hypoxic JJ cord-015021-pol2qm74 2681 22 conditions condition NNS cord-015021-pol2qm74 2681 23 indicating indicate VBG cord-015021-pol2qm74 2681 24 synergism synergism NN cord-015021-pol2qm74 2681 25 with with IN cord-015021-pol2qm74 2681 26 NO no NN cord-015021-pol2qm74 2681 27 - - HYPH cord-015021-pol2qm74 2681 28 and and CC cord-015021-pol2qm74 2681 29 02 02 CD cord-015021-pol2qm74 2681 30 . . . cord-015021-pol2qm74 2682 1 Conclusions conclusion NNS cord-015021-pol2qm74 2682 2 : : : cord-015021-pol2qm74 2683 1 We -PRON- PRP cord-015021-pol2qm74 2683 2 conclude conclude VBP cord-015021-pol2qm74 2683 3 , , , cord-015021-pol2qm74 2683 4 that that IN cord-015021-pol2qm74 2683 5 NO.-induced no.-induced JJ cord-015021-pol2qm74 2683 6 toxicity toxicity NN cord-015021-pol2qm74 2683 7 against against IN cord-015021-pol2qm74 2683 8 endothelial endothelial JJ cord-015021-pol2qm74 2683 9 cells cell NNS cord-015021-pol2qm74 2683 10 is be VBZ cord-015021-pol2qm74 2683 11 enhanced enhance VBN cord-015021-pol2qm74 2683 12 slightly slightly RB cord-015021-pol2qm74 2683 13 in in IN cord-015021-pol2qm74 2683 14 the the DT cord-015021-pol2qm74 2683 15 presence presence NN cord-015021-pol2qm74 2683 16 of of IN cord-015021-pol2qm74 2683 17 oxygen oxygen NN cord-015021-pol2qm74 2683 18 and and CC cord-015021-pol2qm74 2683 19 is be VBZ cord-015021-pol2qm74 2683 20 not not RB cord-015021-pol2qm74 2683 21 due due JJ cord-015021-pol2qm74 2683 22 to to IN cord-015021-pol2qm74 2683 23 an an DT cord-015021-pol2qm74 2683 24 interaction interaction NN cord-015021-pol2qm74 2683 25 with with IN cord-015021-pol2qm74 2683 26 02- 02- NNP cord-015021-pol2qm74 2683 27 . . . cord-015021-pol2qm74 2684 1 However however RB cord-015021-pol2qm74 2684 2 , , , cord-015021-pol2qm74 2684 3 toxicity toxicity NN cord-015021-pol2qm74 2684 4 increases increase NNS cord-015021-pol2qm74 2684 5 dramatically dramatically RB cord-015021-pol2qm74 2684 6 in in IN cord-015021-pol2qm74 2684 7 the the DT cord-015021-pol2qm74 2684 8 presence presence NN cord-015021-pol2qm74 2684 9 of of IN cord-015021-pol2qm74 2684 10 H202 H202 NNP cord-015021-pol2qm74 2684 11 . . . cord-015021-pol2qm74 2685 1 This this DT cord-015021-pol2qm74 2685 2 may may MD cord-015021-pol2qm74 2685 3 possibly possibly RB cord-015021-pol2qm74 2685 4 occur occur VB cord-015021-pol2qm74 2685 5 either either RB cord-015021-pol2qm74 2685 6 by by IN cord-015021-pol2qm74 2685 7 a a DT cord-015021-pol2qm74 2685 8 chemical chemical JJ cord-015021-pol2qm74 2685 9 formation formation NN cord-015021-pol2qm74 2685 10 of of IN cord-015021-pol2qm74 2685 11 more more RBR cord-015021-pol2qm74 2685 12 potent potent JJ cord-015021-pol2qm74 2685 13 reactive reactive JJ cord-015021-pol2qm74 2685 14 hydroxyl hydroxyl NN cord-015021-pol2qm74 2685 15 radicals radical NNS cord-015021-pol2qm74 2685 16 or or CC cord-015021-pol2qm74 2685 17 by by IN cord-015021-pol2qm74 2685 18 independent independent JJ cord-015021-pol2qm74 2685 19 actions action NNS cord-015021-pol2qm74 2685 20 on on IN cord-015021-pol2qm74 2685 21 different different JJ cord-015021-pol2qm74 2685 22 cellular cellular JJ cord-015021-pol2qm74 2685 23 targets target NNS cord-015021-pol2qm74 2685 24 . . . cord-015021-pol2qm74 2685 25 _SP cord-015021-pol2qm74 2686 1 Although although IN cord-015021-pol2qm74 2686 2 it -PRON- PRP cord-015021-pol2qm74 2686 3 is be VBZ cord-015021-pol2qm74 2686 4 becoming become VBG cord-015021-pol2qm74 2686 5 increasingly increasingly RB cord-015021-pol2qm74 2686 6 clear clear JJ cord-015021-pol2qm74 2686 7 that that IN cord-015021-pol2qm74 2686 8 Nitric nitric NN cord-015021-pol2qm74 2686 9 Oxide oxide NN cord-015021-pol2qm74 2686 10 ( ( -LRB- cord-015021-pol2qm74 2686 11 NO no UH cord-015021-pol2qm74 2686 12 ) ) -RRB- cord-015021-pol2qm74 2686 13 is be VBZ cord-015021-pol2qm74 2686 14 associated associate VBN cord-015021-pol2qm74 2686 15 with with IN cord-015021-pol2qm74 2686 16 otxan otxan JJ cord-015021-pol2qm74 2686 17 dysfunctions dysfunction NNS cord-015021-pol2qm74 2686 18 in in IN cord-015021-pol2qm74 2686 19 septic septic JJ cord-015021-pol2qm74 2686 20 patients patient NNS cord-015021-pol2qm74 2686 21 , , , cord-015021-pol2qm74 2686 22 little little JJ cord-015021-pol2qm74 2686 23 is be VBZ cord-015021-pol2qm74 2686 24 known know VBN cord-015021-pol2qm74 2686 25 as as IN cord-015021-pol2qm74 2686 26 to to TO cord-015021-pol2qm74 2686 27 die die VB cord-015021-pol2qm74 2686 28 kinetics kinetic NNS cord-015021-pol2qm74 2686 29 of of IN cord-015021-pol2qm74 2686 30 NO no DT cord-015021-pol2qm74 2686 31 production production NN cord-015021-pol2qm74 2686 32 in in IN cord-015021-pol2qm74 2686 33 these these DT cord-015021-pol2qm74 2686 34 patients patient NNS cord-015021-pol2qm74 2686 35 To to TO cord-015021-pol2qm74 2686 36 clarify clarify VB cord-015021-pol2qm74 2686 37 these these DT cord-015021-pol2qm74 2686 38 kinetics kinetic NNS cord-015021-pol2qm74 2686 39 , , , cord-015021-pol2qm74 2686 40 we -PRON- PRP cord-015021-pol2qm74 2686 41 have have VBP cord-015021-pol2qm74 2686 42 investegated investegate VBN cord-015021-pol2qm74 2686 43 serum serum NN cord-015021-pol2qm74 2686 44 arid arid JJ cord-015021-pol2qm74 2686 45 monocyte monocyte NNP cord-015021-pol2qm74 2686 46 associated associate VBD cord-015021-pol2qm74 2686 47 NO no RB cord-015021-pol2qm74 2686 48 in in IN cord-015021-pol2qm74 2686 49 septic septic JJ cord-015021-pol2qm74 2686 50 patients patient NNS cord-015021-pol2qm74 2686 51 . . . cord-015021-pol2qm74 2687 1 Five five CD cord-015021-pol2qm74 2687 2 patients patient NNS cord-015021-pol2qm74 2687 3 who who WP cord-015021-pol2qm74 2687 4 had have VBD cord-015021-pol2qm74 2687 5 undergone undergo VBN cord-015021-pol2qm74 2687 6 gastrointestinal gastrointestinal JJ cord-015021-pol2qm74 2687 7 surgeries surgery NNS cord-015021-pol2qm74 2687 8 mid mid NNP cord-015021-pol2qm74 2687 9 were be VBD cord-015021-pol2qm74 2687 10 complicated complicated JJ cord-015021-pol2qm74 2687 11 postoperatively postoperatively RB cord-015021-pol2qm74 2687 12 with with IN cord-015021-pol2qm74 2687 13 severe severe JJ cord-015021-pol2qm74 2687 14 sepsis sepsis NN cord-015021-pol2qm74 2687 15 served serve VBD cord-015021-pol2qm74 2687 16 as as IN cord-015021-pol2qm74 2687 17 the the DT cord-015021-pol2qm74 2687 18 subjects subject NNS cord-015021-pol2qm74 2687 19 in in IN cord-015021-pol2qm74 2687 20 this this DT cord-015021-pol2qm74 2687 21 study study NN cord-015021-pol2qm74 2687 22 ( ( -LRB- cord-015021-pol2qm74 2687 23 Sgroup Sgroup NNP cord-015021-pol2qm74 2687 24 ) ) -RRB- cord-015021-pol2qm74 2687 25 , , , cord-015021-pol2qm74 2687 26 using use VBG cord-015021-pol2qm74 2687 27 twelve twelve CD cord-015021-pol2qm74 2687 28 healthy healthy JJ cord-015021-pol2qm74 2687 29 volunteers volunteer NNS cord-015021-pol2qm74 2687 30 as as IN cord-015021-pol2qm74 2687 31 a a DT cord-015021-pol2qm74 2687 32 control control NN cord-015021-pol2qm74 2687 33 group group NN cord-015021-pol2qm74 2687 34 ( ( -LRB- cord-015021-pol2qm74 2687 35 C C NNP cord-015021-pol2qm74 2687 36 group group NN cord-015021-pol2qm74 2687 37 ) ) -RRB- cord-015021-pol2qm74 2687 38 . . . cord-015021-pol2qm74 2688 1 Serum serum NN cord-015021-pol2qm74 2688 2 NO2 NO2 NNP cord-015021-pol2qm74 2688 3 and and CC cord-015021-pol2qm74 2688 4 NO3 NO3 NNP cord-015021-pol2qm74 2688 5 levels level NNS cord-015021-pol2qm74 2688 6 were be VBD cord-015021-pol2qm74 2688 7 measul*d measul*d NNP cord-015021-pol2qm74 2688 8 sliectrophotometricallyMonocyte sliectrophotometricallyMonocyte NNP cord-015021-pol2qm74 2688 9 cultures culture NNS cord-015021-pol2qm74 2688 10 were be VBD cord-015021-pol2qm74 2688 11 done do VBN cord-015021-pol2qm74 2688 12 for for IN cord-015021-pol2qm74 2688 13 24 24 CD cord-015021-pol2qm74 2688 14 Itrs Itrs NNP cord-015021-pol2qm74 2688 15 with with IN cord-015021-pol2qm74 2688 16 or or CC cord-015021-pol2qm74 2688 17 without without IN cord-015021-pol2qm74 2688 18 LPS+IFN lps+ifn NN cord-015021-pol2qm74 2688 19 - - HYPH cord-015021-pol2qm74 2688 20 T t NN cord-015021-pol2qm74 2688 21 stimulation stimulation NN cord-015021-pol2qm74 2688 22 mid mid IN cord-015021-pol2qm74 2688 23 NO2 NO2 NNP cord-015021-pol2qm74 2688 24 and and CC cord-015021-pol2qm74 2688 25 NO3 NO3 NNP cord-015021-pol2qm74 2688 26 levels level NNS cord-015021-pol2qm74 2688 27 in in IN cord-015021-pol2qm74 2688 28 the the DT cord-015021-pol2qm74 2688 29 supernat,'utts supernat,'utts NN cord-015021-pol2qm74 2688 30 were be VBD cord-015021-pol2qm74 2688 31 also also RB cord-015021-pol2qm74 2688 32 measured measure VBN cord-015021-pol2qm74 2688 33 spectrophotometrically spectrophotometrically RB cord-015021-pol2qm74 2688 34 . . . cord-015021-pol2qm74 2689 1 Furthermore furthermore RB cord-015021-pol2qm74 2689 2 , , , cord-015021-pol2qm74 2689 3 using use VBG cord-015021-pol2qm74 2689 4 an an DT cord-015021-pol2qm74 2689 5 NO no DT cord-015021-pol2qm74 2689 6 selective selective JJ cord-015021-pol2qm74 2689 7 electrode electrode NN cord-015021-pol2qm74 2689 8 , , , cord-015021-pol2qm74 2689 9 time time NN cord-015021-pol2qm74 2689 10 course course NN cord-015021-pol2qm74 2689 11 of of IN cord-015021-pol2qm74 2689 12 the the DT cord-015021-pol2qm74 2689 13 LPS+IFN LPS+IFN NNP cord-015021-pol2qm74 2689 14 - - HYPH cord-015021-pol2qm74 2689 15 T T NNP cord-015021-pol2qm74 2689 16 induced induce VBD cord-015021-pol2qm74 2689 17 NO no DT cord-015021-pol2qm74 2689 18 production production NN cord-015021-pol2qm74 2689 19 by by IN cord-015021-pol2qm74 2689 20 monocytes monocyte NNS cord-015021-pol2qm74 2689 21 was be VBD cord-015021-pol2qm74 2689 22 studied study VBN cord-015021-pol2qm74 2689 23 . . . cord-015021-pol2qm74 2690 1 l l LS cord-015021-pol2qm74 2690 2 ) ) -RRB- cord-015021-pol2qm74 2690 3 Serum serum NN cord-015021-pol2qm74 2690 4 NO2 NO2 NNP cord-015021-pol2qm74 2690 5 levels level NNS cord-015021-pol2qm74 2690 6 in in IN cord-015021-pol2qm74 2690 7 S S NNP cord-015021-pol2qm74 2690 8 group group NN cord-015021-pol2qm74 2690 9 were be VBD cord-015021-pol2qm74 2690 10 slightly slightly RB cord-015021-pol2qm74 2690 11 lfigher lfigh JJR cord-015021-pol2qm74 2690 12 than than IN cord-015021-pol2qm74 2690 13 dmse dmse NNP cord-015021-pol2qm74 2690 14 in in IN cord-015021-pol2qm74 2690 15 C C NNP cord-015021-pol2qm74 2690 16 group group NN cord-015021-pol2qm74 2690 17 , , , cord-015021-pol2qm74 2690 18 bnt bnt VBP cord-015021-pol2qm74 2690 19 there there EX cord-015021-pol2qm74 2690 20 were be VBD cord-015021-pol2qm74 2690 21 no no DT cord-015021-pol2qm74 2690 22 significoatt significoatt JJ cord-015021-pol2qm74 2690 23 differences difference NNS cord-015021-pol2qm74 2690 24 between between IN cord-015021-pol2qm74 2690 25 the the DT cord-015021-pol2qm74 2690 26 two two CD cord-015021-pol2qm74 2690 27 . . . cord-015021-pol2qm74 2691 1 2)Both 2)both CD cord-015021-pol2qm74 2691 2 NO2 NO2 NNP cord-015021-pol2qm74 2691 3 levels level NNS cord-015021-pol2qm74 2691 4 in in IN cord-015021-pol2qm74 2691 5 the the DT cord-015021-pol2qm74 2691 6 supematmlts supematmlts NN cord-015021-pol2qm74 2691 7 of of IN cord-015021-pol2qm74 2691 8 monocytes monocyte NNS cord-015021-pol2qm74 2691 9 cultured culture VBN cord-015021-pol2qm74 2691 10 with with IN cord-015021-pol2qm74 2691 11 LPS+IFN LPS+IFN NNP cord-015021-pol2qm74 2691 12 - - HYPH cord-015021-pol2qm74 2691 13 T T NNP cord-015021-pol2qm74 2691 14 mid mid NN cord-015021-pol2qm74 2691 15 NO2 NO2 NNP cord-015021-pol2qm74 2691 16 , , , cord-015021-pol2qm74 2691 17 NO3 NO3 NNP cord-015021-pol2qm74 2691 18 levels level NNS cord-015021-pol2qm74 2692 1 ill ill NNP cord-015021-pol2qm74 2692 2 lhe lhe NNP cord-015021-pol2qm74 2692 3 supernatants supernatant NNS cord-015021-pol2qm74 2692 4 of of IN cord-015021-pol2qm74 2692 5 monocytes monocyte NNS cord-015021-pol2qm74 2692 6 cultured culture VBN cord-015021-pol2qm74 2692 7 without without IN cord-015021-pol2qm74 2692 8 LPS+IFN LPS+IFN NNP cord-015021-pol2qm74 2692 9 - - HYPH cord-015021-pol2qm74 2692 10 Y Y NNP cord-015021-pol2qm74 2692 11 were be VBD cord-015021-pol2qm74 2692 12 significantly significantly RB cord-015021-pol2qm74 2692 13 higher high JJR cord-015021-pol2qm74 2692 14 in in IN cord-015021-pol2qm74 2692 15 S S NNP cord-015021-pol2qm74 2692 16 group group NN cord-015021-pol2qm74 2692 17 . . . cord-015021-pol2qm74 2693 1 Further further RB cord-015021-pol2qm74 2693 2 , , , cord-015021-pol2qm74 2693 3 the the DT cord-015021-pol2qm74 2693 4 time time NN cord-015021-pol2qm74 2693 5 required require VBN cord-015021-pol2qm74 2693 6 for for IN cord-015021-pol2qm74 2693 7 the the DT cord-015021-pol2qm74 2693 8 NO no JJ cord-015021-pol2qm74 2693 9 production production NN cord-015021-pol2qm74 2693 10 by by IN cord-015021-pol2qm74 2693 11 enltnred enltnred NNP cord-015021-pol2qm74 2693 12 monoeytes monoeytes NNPS cord-015021-pol2qm74 2693 13 was be VBD cord-015021-pol2qm74 2693 14 siglfificantly siglfificantly RB cord-015021-pol2qm74 2693 15 shorter short JJR cord-015021-pol2qm74 2693 16 also also RB cord-015021-pol2qm74 2693 17 in in IN cord-015021-pol2qm74 2693 18 S S NNP cord-015021-pol2qm74 2693 19 groap groap NN cord-015021-pol2qm74 2693 20 . . . cord-015021-pol2qm74 2694 1 Conclusions conclusion NNS cord-015021-pol2qm74 2694 2 l)In l)In VBD cord-015021-pol2qm74 2694 3 severe severe JJ cord-015021-pol2qm74 2694 4 septic septic JJ cord-015021-pol2qm74 2694 5 patients patient NNS cord-015021-pol2qm74 2694 6 , , , cord-015021-pol2qm74 2694 7 monocyte monocyte NNP cord-015021-pol2qm74 2694 8 NO NO NNP cord-015021-pol2qm74 2694 9 productions production NNS cord-015021-pol2qm74 2695 1 wei~ wei~ NNP cord-015021-pol2qm74 2695 2 not not RB cord-015021-pol2qm74 2695 3 only only RB cord-015021-pol2qm74 2695 4 primed prime VBN cord-015021-pol2qm74 2695 5 , , , cord-015021-pol2qm74 2695 6 but but CC cord-015021-pol2qm74 2695 7 also also RB cord-015021-pol2qm74 2695 8 activated activate VBN cord-015021-pol2qm74 2695 9 concomitantly concomitantly RB cord-015021-pol2qm74 2695 10 , , , cord-015021-pol2qm74 2695 11 suggesting suggest VBG cord-015021-pol2qm74 2695 12 that that IN cord-015021-pol2qm74 2695 13 these these DT cord-015021-pol2qm74 2695 14 monocyte monocyte NNP cord-015021-pol2qm74 2695 15 activations activation NNS cord-015021-pol2qm74 2695 16 m'e m'e RB cord-015021-pol2qm74 2695 17 strongly strongly RB cord-015021-pol2qm74 2695 18 associated associate VBN cord-015021-pol2qm74 2695 19 with with IN cord-015021-pol2qm74 2695 20 organ organ NN cord-015021-pol2qm74 2695 21 dysfunctions dysfunction NNS cord-015021-pol2qm74 2695 22 in in IN cord-015021-pol2qm74 2695 23 sepsis sepsis NN cord-015021-pol2qm74 2695 24 . . . cord-015021-pol2qm74 2696 1 2)Based 2)based CD cord-015021-pol2qm74 2696 2 on on IN cord-015021-pol2qm74 2696 3 the the DT cord-015021-pol2qm74 2696 4 restdts restdts NNP cord-015021-pol2qm74 2696 5 of of IN cord-015021-pol2qm74 2696 6 serum serum NN cord-015021-pol2qm74 2696 7 NO no DT cord-015021-pol2qm74 2696 8 nteasuremeuts nteasuremeut NNS cord-015021-pol2qm74 2696 9 , , , cord-015021-pol2qm74 2696 10 it -PRON- PRP cord-015021-pol2qm74 2696 11 can can MD cord-015021-pol2qm74 2696 12 be be VB cord-015021-pol2qm74 2696 13 deduced deduce VBN cord-015021-pol2qm74 2696 14 that that IN cord-015021-pol2qm74 2696 15 NO no DT cord-015021-pol2qm74 2696 16 p~'oduced p~'oduce VBN cord-015021-pol2qm74 2696 17 by by IN cord-015021-pol2qm74 2696 18 monocytes monocyte NNS cord-015021-pol2qm74 2696 19 in in IN cord-015021-pol2qm74 2696 20 septic septic JJ cord-015021-pol2qm74 2696 21 patients patient NNS cord-015021-pol2qm74 2696 22 affects affect VBZ cord-015021-pol2qm74 2696 23 tissues tissue NNS cord-015021-pol2qm74 2696 24 and and CC cord-015021-pol2qm74 2696 25 org org NN cord-015021-pol2qm74 2696 26 ~ ~ NNP cord-015021-pol2qm74 2696 27 s s XX cord-015021-pol2qm74 2696 28 Ioeoregiomflly Ioeoregiomflly NNP cord-015021-pol2qm74 2696 29 . . . cord-015021-pol2qm74 2697 1 Objectives objective NNS cord-015021-pol2qm74 2697 2 of of IN cord-015021-pol2qm74 2697 3 the the DT cord-015021-pol2qm74 2697 4 study study NN cord-015021-pol2qm74 2697 5 : : : cord-015021-pol2qm74 2697 6 Nitric nitric NN cord-015021-pol2qm74 2697 7 Oxide oxide NN cord-015021-pol2qm74 2697 8 ( ( -LRB- cord-015021-pol2qm74 2697 9 NO no UH cord-015021-pol2qm74 2697 10 ) ) -RRB- cord-015021-pol2qm74 2697 11 is be VBZ cord-015021-pol2qm74 2697 12 an an DT cord-015021-pol2qm74 2697 13 important important JJ cord-015021-pol2qm74 2697 14 messenger messenger NN cord-015021-pol2qm74 2697 15 which which WDT cord-015021-pol2qm74 2697 16 accounts account VBZ cord-015021-pol2qm74 2697 17 for for IN cord-015021-pol2qm74 2697 18 a a DT cord-015021-pol2qm74 2697 19 wide wide JJ cord-015021-pol2qm74 2697 20 spectrum spectrum NN cord-015021-pol2qm74 2697 21 of of IN cord-015021-pol2qm74 2697 22 physiological physiological JJ cord-015021-pol2qm74 2697 23 and and CC cord-015021-pol2qm74 2697 24 pathophysiological pathophysiological JJ cord-015021-pol2qm74 2697 25 processes process NNS cord-015021-pol2qm74 2697 26 , , , cord-015021-pol2qm74 2697 27 e.g. e.g. RB cord-015021-pol2qm74 2697 28 mediating mediate VBG cord-015021-pol2qm74 2697 29 vasodilation vasodilation NN cord-015021-pol2qm74 2697 30 in in IN cord-015021-pol2qm74 2697 31 endoloxin endoloxin NN cord-015021-pol2qm74 2697 32 shock shock NN cord-015021-pol2qm74 2697 33 Investigating investigate VBG cord-015021-pol2qm74 2697 34 the the DT cord-015021-pol2qm74 2697 35 signal signal NN cord-015021-pol2qm74 2697 36 lransducfion lransducfion NN cord-015021-pol2qm74 2697 37 pathways pathway NNS cord-015021-pol2qm74 2697 38 involved involve VBN cord-015021-pol2qm74 2697 39 in in IN cord-015021-pol2qm74 2697 40 the the DT cord-015021-pol2qm74 2697 41 regulation regulation NN cord-015021-pol2qm74 2697 42 of of IN cord-015021-pol2qm74 2697 43 the the DT cord-015021-pol2qm74 2697 44 inducible inducible JJ cord-015021-pol2qm74 2697 45 nitric nitric NN cord-015021-pol2qm74 2697 46 oxide oxide NN cord-015021-pol2qm74 2697 47 synthase synthase NN cord-015021-pol2qm74 2697 48 ( ( -LRB- cord-015021-pol2qm74 2697 49 iNOS inos NN cord-015021-pol2qm74 2697 50 ) ) -RRB- cord-015021-pol2qm74 2697 51 , , , cord-015021-pol2qm74 2697 52 we -PRON- PRP cord-015021-pol2qm74 2697 53 report report VBP cord-015021-pol2qm74 2697 54 the the DT cord-015021-pol2qm74 2697 55 involvement involvement NN cord-015021-pol2qm74 2697 56 of of IN cord-015021-pol2qm74 2697 57 phosphatidylcholinespecific phosphatidylcholinespecific NNP cord-015021-pol2qm74 2697 58 phospholipase phospholipase NNP cord-015021-pol2qm74 2697 59 C C NNP cord-015021-pol2qm74 2697 60 ( ( -LRB- cord-015021-pol2qm74 2697 61 PC PC NNP cord-015021-pol2qm74 2697 62 - - HYPH cord-015021-pol2qm74 2697 63 PLC PLC NNP cord-015021-pol2qm74 2697 64 ) ) -RRB- cord-015021-pol2qm74 2697 65 and and CC cord-015021-pol2qm74 2697 66 proteinkinase proteinkinase NNP cord-015021-pol2qm74 2697 67 C C NNP cord-015021-pol2qm74 2697 68 ( ( -LRB- cord-015021-pol2qm74 2697 69 PKC PKC NNP cord-015021-pol2qm74 2697 70 ) ) -RRB- cord-015021-pol2qm74 2697 71 . . . cord-015021-pol2qm74 2698 1 Materials material NNS cord-015021-pol2qm74 2698 2 and and CC cord-015021-pol2qm74 2698 3 Methods method NNS cord-015021-pol2qm74 2698 4 : : : cord-015021-pol2qm74 2698 5 NO no JJ cord-015021-pol2qm74 2698 6 - - HYPH cord-015021-pol2qm74 2698 7 production production NN cord-015021-pol2qm74 2698 8 was be VBD cord-015021-pol2qm74 2698 9 induced induce VBN cord-015021-pol2qm74 2698 10 in in IN cord-015021-pol2qm74 2698 11 the the DT cord-015021-pol2qm74 2698 12 murine murine JJ cord-015021-pol2qm74 2698 13 macrophage macrophage NN cord-015021-pol2qm74 2698 14 cell cell NN cord-015021-pol2qm74 2698 15 line line NN cord-015021-pol2qm74 2698 16 J774 J774 NNS cord-015021-pol2qm74 2698 17 with with IN cord-015021-pol2qm74 2698 18 lipopolysaccharide lipopolysaccharide NN cord-015021-pol2qm74 2698 19 ( ( -LRB- cord-015021-pol2qm74 2698 20 LPS LPS NNP cord-015021-pol2qm74 2698 21 ) ) -RRB- cord-015021-pol2qm74 2698 22 [ [ -LRB- cord-015021-pol2qm74 2698 23 llJg lljg NN cord-015021-pol2qm74 2698 24 / / SYM cord-015021-pol2qm74 2698 25 ml ml NN cord-015021-pol2qm74 2698 26 ] ] -RRB- cord-015021-pol2qm74 2698 27 and and CC cord-015021-pol2qm74 2698 28 interferon interferon NN cord-015021-pol2qm74 2698 29 ; ; : cord-015021-pol2qm74 2698 30 f f LS cord-015021-pol2qm74 2698 31 ( ( -LRB- cord-015021-pol2qm74 2698 32 IFNy IFNy NNP cord-015021-pol2qm74 2698 33 ) ) -RRB- cord-015021-pol2qm74 2699 1 [ [ -LRB- cord-015021-pol2qm74 2699 2 200U 200u CD cord-015021-pol2qm74 2699 3 / / SYM cord-015021-pol2qm74 2699 4 ml ml NN cord-015021-pol2qm74 2699 5 ] ] -RRB- cord-015021-pol2qm74 2699 6 . . . cord-015021-pol2qm74 2700 1 After after IN cord-015021-pol2qm74 2700 2 18 18 CD cord-015021-pol2qm74 2700 3 hours hour NNS cord-015021-pol2qm74 2700 4 of of IN cord-015021-pol2qm74 2700 5 incubation incubation NN cord-015021-pol2qm74 2700 6 NO no NN cord-015021-pol2qm74 2700 7 - - HYPH cord-015021-pol2qm74 2700 8 release release NN cord-015021-pol2qm74 2700 9 was be VBD cord-015021-pol2qm74 2700 10 determined determine VBN cord-015021-pol2qm74 2700 11 as as IN cord-015021-pol2qm74 2700 12 nitrite nitrite NN cord-015021-pol2qm74 2700 13 ( ( -LRB- cord-015021-pol2qm74 2700 14 NO2 NO2 NNP cord-015021-pol2qm74 2700 15 ) ) -RRB- cord-015021-pol2qm74 2700 16 by by IN cord-015021-pol2qm74 2700 17 using use VBG cord-015021-pol2qm74 2700 18 a a DT cord-015021-pol2qm74 2700 19 colorimetric colorimetric JJ cord-015021-pol2qm74 2700 20 assay assay NN cord-015021-pol2qm74 2700 21 based base VBN cord-015021-pol2qm74 2700 22 on on IN cord-015021-pol2qm74 2700 23 the the DT cord-015021-pol2qm74 2700 24 Griess Griess NNP cord-015021-pol2qm74 2700 25 - - HYPH cord-015021-pol2qm74 2700 26 reaetion reaetion NN cord-015021-pol2qm74 2700 27 . . . cord-015021-pol2qm74 2701 1 Results result NNS cord-015021-pol2qm74 2701 2 : : : cord-015021-pol2qm74 2701 3 Preincubation preincubation NN cord-015021-pol2qm74 2701 4 of of IN cord-015021-pol2qm74 2701 5 cells cell NNS cord-015021-pol2qm74 2701 6 with with IN cord-015021-pol2qm74 2701 7 the the DT cord-015021-pol2qm74 2701 8 PKC PKC NNP cord-015021-pol2qm74 2701 9 - - HYPH cord-015021-pol2qm74 2701 10 inhibitors inhibitor NNS cord-015021-pol2qm74 2701 11 staurosporine staurosporine JJ cord-015021-pol2qm74 2701 12 ( ( -LRB- cord-015021-pol2qm74 2701 13 STP STP NNP cord-015021-pol2qm74 2701 14 ) ) -RRB- cord-015021-pol2qm74 2701 15 , , , cord-015021-pol2qm74 2701 16 chelerythrine chelerythrine NN cord-015021-pol2qm74 2701 17 , , , cord-015021-pol2qm74 2701 18 bisindolylmaleimide bisindolylmaleimide JJ cord-015021-pol2qm74 2701 19 ( ( -LRB- cord-015021-pol2qm74 2701 20 BIM BIM NNP cord-015021-pol2qm74 2701 21 ) ) -RRB- cord-015021-pol2qm74 2701 22 and and CC cord-015021-pol2qm74 2701 23 D609 D609 NNP cord-015021-pol2qm74 2701 24 , , , cord-015021-pol2qm74 2701 25 that that WDT cord-015021-pol2qm74 2701 26 recently recently RB cord-015021-pol2qm74 2701 27 has have VBZ cord-015021-pol2qm74 2701 28 been be VBN cord-015021-pol2qm74 2701 29 identified identify VBN cord-015021-pol2qm74 2701 30 as as IN cord-015021-pol2qm74 2701 31 a a DT cord-015021-pol2qm74 2701 32 selective selective JJ cord-015021-pol2qm74 2701 33 inhibitor inhibitor NN cord-015021-pol2qm74 2701 34 of of IN cord-015021-pol2qm74 2701 35 PC PC NNP cord-015021-pol2qm74 2701 36 - - HYPH cord-015021-pol2qm74 2701 37 PLC PLC NNP cord-015021-pol2qm74 2701 38 , , , cord-015021-pol2qm74 2701 39 diminished diminish VBD cord-015021-pol2qm74 2701 40 significantly significantly RB cord-015021-pol2qm74 2701 41 LPSand LPSand NNP cord-015021-pol2qm74 2701 42 ] ] -RRB- cord-015021-pol2qm74 2701 43 FNT fnt NN cord-015021-pol2qm74 2701 44 - - HYPH cord-015021-pol2qm74 2701 45 induced induce VBN cord-015021-pol2qm74 2701 46 NO2-production no2-production NN cord-015021-pol2qm74 2701 47 ( ( -LRB- cord-015021-pol2qm74 2701 48 p p NN cord-015021-pol2qm74 2701 49 < < XX cord-015021-pol2qm74 2701 50 O,001 O,001 NNP cord-015021-pol2qm74 2701 51 ) ) -RRB- cord-015021-pol2qm74 2701 52 . . . cord-015021-pol2qm74 2702 1 Although although IN cord-015021-pol2qm74 2702 2 we -PRON- PRP cord-015021-pol2qm74 2702 3 observed observe VBD cord-015021-pol2qm74 2702 4 no no DT cord-015021-pol2qm74 2702 5 toxic toxic JJ cord-015021-pol2qm74 2702 6 effect effect NN cord-015021-pol2qm74 2702 7 on on IN cord-015021-pol2qm74 2702 8 cell cell NN cord-015021-pol2qm74 2702 9 viability viability NN cord-015021-pol2qm74 2702 10 , , , cord-015021-pol2qm74 2702 11 NO2-production no2-production NN cord-015021-pol2qm74 2702 12 was be VBD cord-015021-pol2qm74 2702 13 related relate VBN cord-015021-pol2qm74 2702 14 to to IN cord-015021-pol2qm74 2702 15 protein protein NN cord-015021-pol2qm74 2702 16 concentrations concentration NNS cord-015021-pol2qm74 2702 17 to to TO cord-015021-pol2qm74 2702 18 exclude exclude VB cord-015021-pol2qm74 2702 19 any any DT cord-015021-pol2qm74 2702 20 inhibitory inhibitory JJ cord-015021-pol2qm74 2702 21 effect effect NN cord-015021-pol2qm74 2702 22 on on IN cord-015021-pol2qm74 2702 23 celt celt JJ cord-015021-pol2qm74 2702 24 growth growth NN cord-015021-pol2qm74 2702 25 . . . cord-015021-pol2qm74 2703 1 Celts Celts NNPS cord-015021-pol2qm74 2703 2 preincubated preincubate VBD cord-015021-pol2qm74 2703 3 with with IN cord-015021-pol2qm74 2703 4 STP STP NNP cord-015021-pol2qm74 2703 5 [ [ -LRB- cord-015021-pol2qm74 2703 6 lO0nM lO0nM NNP cord-015021-pol2qm74 2703 7 ] ] -RRB- cord-015021-pol2qm74 2703 8 released release VBN cord-015021-pol2qm74 2703 9 20 20 CD cord-015021-pol2qm74 2703 10 % % NN cord-015021-pol2qm74 2703 11 less less JJR cord-015021-pol2qm74 2703 12 NO no DT cord-015021-pol2qm74 2703 13 2 2 CD cord-015021-pol2qm74 2703 14 in in IN cord-015021-pol2qm74 2703 15 response response NN cord-015021-pol2qm74 2703 16 to to IN cord-015021-pol2qm74 2703 17 LPS LPS NNP cord-015021-pol2qm74 2703 18 and and CC cord-015021-pol2qm74 2703 19 IFN IFN NNP cord-015021-pol2qm74 2703 20 , , , cord-015021-pol2qm74 2703 21 [ [ -LRB- cord-015021-pol2qm74 2703 22 compared compare VBN cord-015021-pol2qm74 2703 23 to to TO cord-015021-pol2qm74 2703 24 control control NN cord-015021-pol2qm74 2703 25 cells cell NNS cord-015021-pol2qm74 2703 26 cultured culture VBN cord-015021-pol2qm74 2703 27 without without IN cord-015021-pol2qm74 2703 28 inhibitor inhibitor NN cord-015021-pol2qm74 2703 29 . . . cord-015021-pol2qm74 2704 1 Chelerythrine Chelerythrine NNP cord-015021-pol2qm74 2704 2 [ [ -LRB- cord-015021-pol2qm74 2704 3 30}JM 30}jm CD cord-015021-pol2qm74 2704 4 ] ] -RRB- cord-015021-pol2qm74 2704 5 and and CC cord-015021-pol2qm74 2704 6 BIM BIM NNP cord-015021-pol2qm74 2704 7 [ [ -LRB- cord-015021-pol2qm74 2704 8 IOIJM IOIJM NNP cord-015021-pol2qm74 2704 9 ] ] -RRB- cord-015021-pol2qm74 2704 10 reduced reduce VBD cord-015021-pol2qm74 2704 11 the the DT cord-015021-pol2qm74 2704 12 NO2-formation no2-formation NN cord-015021-pol2qm74 2704 13 by by IN cord-015021-pol2qm74 2704 14 50 50 CD cord-015021-pol2qm74 2704 15 % % NN cord-015021-pol2qm74 2704 16 and and CC cord-015021-pol2qm74 2704 17 85 85 CD cord-015021-pol2qm74 2704 18 % % NN cord-015021-pol2qm74 2704 19 , , , cord-015021-pol2qm74 2704 20 respectively respectively RB cord-015021-pol2qm74 2704 21 . . . cord-015021-pol2qm74 2705 1 Interestingly interestingly RB cord-015021-pol2qm74 2705 2 , , , cord-015021-pol2qm74 2705 3 the the DT cord-015021-pol2qm74 2705 4 most most RBS cord-015021-pol2qm74 2705 5 potent potent JJ cord-015021-pol2qm74 2705 6 inhibitor inhibitor NN cord-015021-pol2qm74 2705 7 of of IN cord-015021-pol2qm74 2705 8 NO no JJ cord-015021-pol2qm74 2705 9 - - HYPH cord-015021-pol2qm74 2705 10 production production NN cord-015021-pol2qm74 2705 11 turned turn VBD cord-015021-pol2qm74 2705 12 out out RP cord-015021-pol2qm74 2705 13 to to TO cord-015021-pol2qm74 2705 14 be be VB cord-015021-pol2qm74 2705 15 the the DT cord-015021-pol2qm74 2705 16 xanthate xanthate NNP cord-015021-pol2qm74 2705 17 D609 D609 NNP cord-015021-pol2qm74 2705 18 Cells Cells NNP cord-015021-pol2qm74 2705 19 pretreated pretreate VBD cord-015021-pol2qm74 2705 20 with with IN cord-015021-pol2qm74 2705 21 D609 D609 NNPS cord-015021-pol2qm74 2705 22 [ [ -LRB- cord-015021-pol2qm74 2705 23 301~g 301~g CD cord-015021-pol2qm74 2705 24 / / SYM cord-015021-pol2qm74 2705 25 mt mt NNP cord-015021-pol2qm74 2705 26 ] ] -RRB- cord-015021-pol2qm74 2705 27 released release VBD cord-015021-pol2qm74 2705 28 96 96 CD cord-015021-pol2qm74 2705 29 % % NN cord-015021-pol2qm74 2705 30 less less JJR cord-015021-pol2qm74 2705 31 NO no DT cord-015021-pol2qm74 2705 32 2 2 CD cord-015021-pol2qm74 2705 33 than than IN cord-015021-pol2qm74 2705 34 stimulated stimulated JJ cord-015021-pol2qm74 2705 35 controls control NNS cord-015021-pol2qm74 2706 1 The the DT cord-015021-pol2qm74 2706 2 inhibitory inhibitory JJ cord-015021-pol2qm74 2706 3 effect effect NN cord-015021-pol2qm74 2706 4 on on IN cord-015021-pol2qm74 2706 5 NO no DT cord-015021-pol2qm74 2706 6 2production 2production CD cord-015021-pol2qm74 2706 7 decreased decrease VBD cord-015021-pol2qm74 2706 8 the the DT cord-015021-pol2qm74 2706 9 later later RB cord-015021-pol2qm74 2706 10 the the DT cord-015021-pol2qm74 2706 11 inhibitore inhibitore NN cord-015021-pol2qm74 2706 12 were be VBD cord-015021-pol2qm74 2706 13 added add VBN cord-015021-pol2qm74 2706 14 after after IN cord-015021-pol2qm74 2706 15 stimulation stimulation NN cord-015021-pol2qm74 2706 16 ; ; : cord-015021-pol2qm74 2706 17 e.g. e.g. RB cord-015021-pol2qm74 2706 18 BIM BIM NNP cord-015021-pol2qm74 2706 19 added add VBD cord-015021-pol2qm74 2706 20 6 6 CD cord-015021-pol2qm74 2706 21 and and CC cord-015021-pol2qm74 2706 22 12 12 CD cord-015021-pol2qm74 2706 23 hours hour NNS cord-015021-pol2qm74 2706 24 after after IN cord-015021-pol2qm74 2706 25 stimulation stimulation NN cord-015021-pol2qm74 2706 26 reduced reduce VBD cord-015021-pol2qm74 2706 27 NO2-production no2-production NN cord-015021-pol2qm74 2706 28 only only RB cord-015021-pol2qm74 2706 29 by by IN cord-015021-pol2qm74 2706 30 50 50 CD cord-015021-pol2qm74 2706 31 % % NN cord-015021-pol2qm74 2706 32 and and CC cord-015021-pol2qm74 2706 33 12 12 CD cord-015021-pol2qm74 2706 34 % % NN cord-015021-pol2qm74 2706 35 , , , cord-015021-pol2qm74 2706 36 respectively respectively RB cord-015021-pol2qm74 2706 37 . . . cord-015021-pol2qm74 2707 1 Accordingly accordingly RB cord-015021-pol2qm74 2707 2 , , , cord-015021-pol2qm74 2707 3 iNQS inqs JJ cord-015021-pol2qm74 2707 4 activity activity NN cord-015021-pol2qm74 2707 5 present present NN cord-015021-pol2qm74 2707 6 in in IN cord-015021-pol2qm74 2707 7 stimulated stimulated JJ cord-015021-pol2qm74 2707 8 cell cell NN cord-015021-pol2qm74 2707 9 lysates lysate NNS cord-015021-pol2qm74 2707 10 supplemented supplement VBN cord-015021-pol2qm74 2707 11 with with IN cord-015021-pol2qm74 2707 12 L l NN cord-015021-pol2qm74 2707 13 - - HYPH cord-015021-pol2qm74 2707 14 arginine arginine NN cord-015021-pol2qm74 2707 15 and and CC cord-015021-pol2qm74 2707 16 co co NNS cord-015021-pol2qm74 2707 17 - - NNS cord-015021-pol2qm74 2707 18 factors factor NNS cord-015021-pol2qm74 2707 19 was be VBD cord-015021-pol2qm74 2707 20 not not RB cord-015021-pol2qm74 2707 21 suppressed suppress VBN cord-015021-pol2qm74 2707 22 by by IN cord-015021-pol2qm74 2707 23 the the DT cord-015021-pol2qm74 2707 24 inhibitors inhibitor NNS cord-015021-pol2qm74 2707 25 tested test VBN cord-015021-pol2qm74 2707 26 . . . cord-015021-pol2qm74 2708 1 Conclusions conclusion NNS cord-015021-pol2qm74 2708 2 : : : cord-015021-pol2qm74 2709 1 Our -PRON- PRP$ cord-015021-pol2qm74 2709 2 findings finding NNS cord-015021-pol2qm74 2709 3 suggest suggest VBP cord-015021-pol2qm74 2709 4 , , , cord-015021-pol2qm74 2709 5 that that IN cord-015021-pol2qm74 2709 6 the the DT cord-015021-pol2qm74 2709 7 induction induction NN cord-015021-pol2qm74 2709 8 of of IN cord-015021-pol2qm74 2709 9 iNOS inos NN cord-015021-pol2qm74 2709 10 but but CC cord-015021-pol2qm74 2709 11 not not RB cord-015021-pol2qm74 2709 12 its -PRON- PRP$ cord-015021-pol2qm74 2709 13 activity activity NN cord-015021-pol2qm74 2709 14 is be VBZ cord-015021-pol2qm74 2709 15 a a DT cord-015021-pol2qm74 2709 16 PKC PKC NNP cord-015021-pol2qm74 2709 17 and and CC cord-015021-pol2qm74 2709 18 particularly particularly RB cord-015021-pol2qm74 2709 19 PC PC NNP cord-015021-pol2qm74 2709 20 - - HYPH cord-015021-pol2qm74 2709 21 PLC plc NN cord-015021-pol2qm74 2709 22 dependent dependent JJ cord-015021-pol2qm74 2709 23 process process NN cord-015021-pol2qm74 2709 24 . . . cord-015021-pol2qm74 2710 1 Dr. Dr. NNP cord-015021-pol2qm74 2710 2 K K NNP cord-015021-pol2qm74 2710 3 Tschaikowsky Tschaikowsky NNP cord-015021-pol2qm74 2710 4 , , , cord-015021-pol2qm74 2710 5 Institut Institut NNP cord-015021-pol2qm74 2710 6 for for IN cord-015021-pol2qm74 2710 7 Anaesthesiologie Anaesthesiologie NNP cord-015021-pol2qm74 2710 8 , , , cord-015021-pol2qm74 2710 9 Universital Universital NNP cord-015021-pol2qm74 2710 10 Erlangen Erlangen NNP cord-015021-pol2qm74 2710 11 -- -- : cord-015021-pol2qm74 2710 12 NQrnberg NQrnberg NNP cord-015021-pol2qm74 2710 13 , , , cord-015021-pol2qm74 2710 14 Krankenhausstr Krankenhausstr NNP cord-015021-pol2qm74 2710 15 12 12 CD cord-015021-pol2qm74 2710 16 , , , cord-015021-pol2qm74 2710 17 91054 91054 CD cord-015021-pol2qm74 2710 18 Erlangen Erlangen NNP cord-015021-pol2qm74 2710 19 Interleukin-1 Interleukin-1 NNP cord-015021-pol2qm74 2710 20 ( ( -LRB- cord-015021-pol2qm74 2710 21 IL-1 IL-1 NNP cord-015021-pol2qm74 2710 22 ) ) -RRB- cord-015021-pol2qm74 2710 23 affects affect VBZ cord-015021-pol2qm74 2710 24 nearly nearly RB cord-015021-pol2qm74 2710 25 every every DT cord-015021-pol2qm74 2710 26 cell cell NN cord-015021-pol2qm74 2710 27 type type NN cord-015021-pol2qm74 2710 28 by by IN cord-015021-pol2qm74 2710 29 increasing increase VBG cord-015021-pol2qm74 2710 30 the the DT cord-015021-pol2qm74 2710 31 expression expression NN cord-015021-pol2qm74 2710 32 of of IN cord-015021-pol2qm74 2710 33 a a DT cord-015021-pol2qm74 2710 34 variety variety NN cord-015021-pol2qm74 2710 35 of of IN cord-015021-pol2qm74 2710 36 genes gene NNS cord-015021-pol2qm74 2710 37 associated associate VBN cord-015021-pol2qm74 2710 38 with with IN cord-015021-pol2qm74 2710 39 the the DT cord-015021-pol2qm74 2710 40 promotion promotion NN cord-015021-pol2qm74 2710 41 of of IN cord-015021-pol2qm74 2710 42 inflammatory inflammatory JJ cord-015021-pol2qm74 2710 43 processes process NNS cord-015021-pol2qm74 2710 44 . . . cord-015021-pol2qm74 2711 1 These these DT cord-015021-pol2qm74 2711 2 include include VBP cord-015021-pol2qm74 2711 3 upregulation upregulation NN cord-015021-pol2qm74 2711 4 of of IN cord-015021-pol2qm74 2711 5 cyclooxygenase cyclooxygenase NN cord-015021-pol2qm74 2711 6 and and CC cord-015021-pol2qm74 2711 7 nitric nitric JJ cord-015021-pol2qm74 2711 8 acid acid NN cord-015021-pol2qm74 2711 9 synthases synthase NNS cord-015021-pol2qm74 2711 10 . . . cord-015021-pol2qm74 2712 1 The the DT cord-015021-pol2qm74 2712 2 IL-1RI IL-1RI NNP cord-015021-pol2qm74 2712 3 transmits transmit VBZ cord-015021-pol2qm74 2712 4 a a DT cord-015021-pol2qm74 2712 5 signal(s signal(s NNP cord-015021-pol2qm74 2712 6 ) ) -RRB- cord-015021-pol2qm74 2712 7 through through IN cord-015021-pol2qm74 2712 8 the the DT cord-015021-pol2qm74 2712 9 cytoplasmic cytoplasmic JJ cord-015021-pol2qm74 2712 10 domain domain NN cord-015021-pol2qm74 2712 11 which which WDT cord-015021-pol2qm74 2712 12 is be VBZ cord-015021-pol2qm74 2712 13 structurally structurally RB cord-015021-pol2qm74 2712 14 related related JJ cord-015021-pol2qm74 2712 15 to to IN cord-015021-pol2qm74 2712 16 the the DT cord-015021-pol2qm74 2712 17 fruit fruit NN cord-015021-pol2qm74 2712 18 fly fly VB cord-015021-pol2qm74 2712 19 Toll toll NN cord-015021-pol2qm74 2712 20 protein protein NN cord-015021-pol2qm74 2712 21 . . . cord-015021-pol2qm74 2713 1 We -PRON- PRP cord-015021-pol2qm74 2713 2 have have VBP cord-015021-pol2qm74 2713 3 recently recently RB cord-015021-pol2qm74 2713 4 cloned clone VBN cord-015021-pol2qm74 2713 5 the the DT cord-015021-pol2qm74 2713 6 promotor promotor NN cord-015021-pol2qm74 2713 7 most most RBS cord-015021-pol2qm74 2713 8 proximal proximal JJ cord-015021-pol2qm74 2713 9 to to IN cord-015021-pol2qm74 2713 10 the the DT cord-015021-pol2qm74 2713 11 5 5 CD cord-015021-pol2qm74 2713 12 ' ' POS cord-015021-pol2qm74 2713 13 UTR UTR NNP cord-015021-pol2qm74 2713 14 of of IN cord-015021-pol2qm74 2713 15 the the DT cord-015021-pol2qm74 2713 16 human human JJ cord-015021-pol2qm74 2713 17 IL-1RI IL-1RI NNP cord-015021-pol2qm74 2713 18 gene gene NN cord-015021-pol2qm74 2713 19 . . . cord-015021-pol2qm74 2714 1 The the DT cord-015021-pol2qm74 2714 2 genomic genomic JJ cord-015021-pol2qm74 2714 3 sequences sequence NNS cord-015021-pol2qm74 2714 4 reveal reveal VBP cord-015021-pol2qm74 2714 5 a a DT cord-015021-pol2qm74 2714 6 lack lack NN cord-015021-pol2qm74 2714 7 of of IN cord-015021-pol2qm74 2714 8 TATA TATA NNP cord-015021-pol2qm74 2714 9 and and CC cord-015021-pol2qm74 2714 10 CAAT CAAT NNP cord-015021-pol2qm74 2714 11 boxes box NNS cord-015021-pol2qm74 2714 12 but but CC cord-015021-pol2qm74 2714 13 rather rather RB cord-015021-pol2qm74 2714 14 a a DT cord-015021-pol2qm74 2714 15 considerable considerable JJ cord-015021-pol2qm74 2714 16 ( ( -LRB- cord-015021-pol2qm74 2714 17 75 75 CD cord-015021-pol2qm74 2714 18 % % NN cord-015021-pol2qm74 2714 19 ) ) -RRB- cord-015021-pol2qm74 2715 1 GC GC NNP cord-015021-pol2qm74 2715 2 rich rich JJ cord-015021-pol2qm74 2715 3 region region NN cord-015021-pol2qm74 2715 4 . . . cord-015021-pol2qm74 2716 1 The the DT cord-015021-pol2qm74 2716 2 translation translation NN cord-015021-pol2qm74 2716 3 of of IN cord-015021-pol2qm74 2716 4 the the DT cord-015021-pol2qm74 2716 5 type type NN cord-015021-pol2qm74 2717 1 I -PRON- PRP cord-015021-pol2qm74 2717 2 IL-1R il-1r VBP cord-015021-pol2qm74 2717 3 appears appear VBZ cord-015021-pol2qm74 2717 4 under under IN cord-015021-pol2qm74 2717 5 a a DT cord-015021-pol2qm74 2717 6 significant significant JJ cord-015021-pol2qm74 2717 7 suppression suppression NN cord-015021-pol2qm74 2717 8 and and CC cord-015021-pol2qm74 2717 9 may may MD cord-015021-pol2qm74 2717 10 limit limit VB cord-015021-pol2qm74 2717 11 the the DT cord-015021-pol2qm74 2717 12 biological biological JJ cord-015021-pol2qm74 2717 13 activities activity NNS cord-015021-pol2qm74 2717 14 of of IN cord-015021-pol2qm74 2717 15 IL-1 IL-1 NNP cord-015021-pol2qm74 2717 16 by by IN cord-015021-pol2qm74 2717 17 low low JJ cord-015021-pol2qm74 2717 18 level level NN cord-015021-pol2qm74 2717 19 of of IN cord-015021-pol2qm74 2717 20 expression expression NN cord-015021-pol2qm74 2717 21 . . . cord-015021-pol2qm74 2718 1 On on IN cord-015021-pol2qm74 2718 2 the the DT cord-015021-pol2qm74 2718 3 other other JJ cord-015021-pol2qm74 2718 4 hand hand NN cord-015021-pol2qm74 2718 5 , , , cord-015021-pol2qm74 2718 6 the the DT cord-015021-pol2qm74 2718 7 type type NN cord-015021-pol2qm74 2718 8 II II NNP cord-015021-pol2qm74 2718 9 IL-1R IL-1R NNP cord-015021-pol2qm74 2718 10 , , , cord-015021-pol2qm74 2718 11 lacking lack VBG cord-015021-pol2qm74 2718 12 a a DT cord-015021-pol2qm74 2718 13 significant significant JJ cord-015021-pol2qm74 2718 14 cytoplasmic cytoplasmic JJ cord-015021-pol2qm74 2718 15 domain domain NN cord-015021-pol2qm74 2718 16 , , , cord-015021-pol2qm74 2718 17 does do VBZ cord-015021-pol2qm74 2718 18 not not RB cord-015021-pol2qm74 2718 19 transmit transmit VB cord-015021-pol2qm74 2718 20 a a DT cord-015021-pol2qm74 2718 21 signal signal NN cord-015021-pol2qm74 2718 22 and and CC cord-015021-pol2qm74 2718 23 acts act VBZ cord-015021-pol2qm74 2718 24 as as IN cord-015021-pol2qm74 2718 25 a a DT cord-015021-pol2qm74 2718 26 decoy decoy NN cord-015021-pol2qm74 2718 27 receptor receptor NN cord-015021-pol2qm74 2718 28 preventing prevent VBG cord-015021-pol2qm74 2718 29 the the DT cord-015021-pol2qm74 2718 30 binding binding NN cord-015021-pol2qm74 2718 31 to to IN cord-015021-pol2qm74 2718 32 the the DT cord-015021-pol2qm74 2718 33 type type NN cord-015021-pol2qm74 2718 34 I -PRON- PRP cord-015021-pol2qm74 2718 35 receptor receptor NN cord-015021-pol2qm74 2718 36 . . . cord-015021-pol2qm74 2719 1 There there EX cord-015021-pol2qm74 2719 2 are be VBP cord-015021-pol2qm74 2719 3 several several JJ cord-015021-pol2qm74 2719 4 approaches approach NNS cord-015021-pol2qm74 2719 5 to to IN cord-015021-pol2qm74 2719 6 reducing reduce VBG cord-015021-pol2qm74 2719 7 IL-1 IL-1 NNP cord-015021-pol2qm74 2719 8 activity activity NN cord-015021-pol2qm74 2719 9 ; ; : cord-015021-pol2qm74 2719 10 inhibition inhibition NN cord-015021-pol2qm74 2719 11 of of IN cord-015021-pol2qm74 2719 12 IL-1 IL-1 NNP cord-015021-pol2qm74 2719 13 converting convert VBG cord-015021-pol2qm74 2719 14 enzyme enzyme NN cord-015021-pol2qm74 2719 15 which which WDT cord-015021-pol2qm74 2719 16 cleaves cleave VBZ cord-015021-pol2qm74 2719 17 pro pro JJ cord-015021-pol2qm74 2719 18 - - JJ cord-015021-pol2qm74 2719 19 IL IL NNP cord-015021-pol2qm74 2719 20 - - HYPH cord-015021-pol2qm74 2719 21 l[3 l[3 JJ cord-015021-pol2qm74 2719 22 , , , cord-015021-pol2qm74 2719 23 anti anti JJ cord-015021-pol2qm74 2719 24 - - NNP cord-015021-pol2qm74 2719 25 IL-1RI il-1ri JJ cord-015021-pol2qm74 2719 26 , , , cord-015021-pol2qm74 2719 27 the the DT cord-015021-pol2qm74 2719 28 IL IL NNP cord-015021-pol2qm74 2719 29 - - HYPH cord-015021-pol2qm74 2719 30 I I NNP cord-015021-pol2qm74 2719 31 receptor receptor NN cord-015021-pol2qm74 2719 32 antagonist antagonist NN cord-015021-pol2qm74 2719 33 ( ( -LRB- cord-015021-pol2qm74 2719 34 IL-1Ra il-1ra NN cord-015021-pol2qm74 2719 35 ) ) -RRB- cord-015021-pol2qm74 2719 36 and and CC cord-015021-pol2qm74 2719 37 soluble soluble JJ cord-015021-pol2qm74 2719 38 ( ( -LRB- cord-015021-pol2qm74 2719 39 extracellular extracellular JJ cord-015021-pol2qm74 2719 40 ) ) -RRB- cord-015021-pol2qm74 2719 41 IL-1RI il-1ri NN cord-015021-pol2qm74 2719 42 and and CC cord-015021-pol2qm74 2719 43 IL-1RII IL-1RII NNP cord-015021-pol2qm74 2719 44 . . . cord-015021-pol2qm74 2720 1 IL-1Ra il-1ra NN cord-015021-pol2qm74 2720 2 is be VBZ cord-015021-pol2qm74 2720 3 structurally structurally RB cord-015021-pol2qm74 2720 4 related related JJ cord-015021-pol2qm74 2720 5 to to IN cord-015021-pol2qm74 2720 6 IL-1 IL-1 NNP cord-015021-pol2qm74 2720 7 and and CC cord-015021-pol2qm74 2720 8 binds bind VBZ cord-015021-pol2qm74 2720 9 at at IN cord-015021-pol2qm74 2720 10 4 4 CD cord-015021-pol2qm74 2720 11 ° ° NN cord-015021-pol2qm74 2720 12 C c NN cord-015021-pol2qm74 2720 13 to to IN cord-015021-pol2qm74 2720 14 the the DT cord-015021-pol2qm74 2720 15 IL-1RI IL-1RI NNP cord-015021-pol2qm74 2720 16 with with IN cord-015021-pol2qm74 2720 17 near near IN cord-015021-pol2qm74 2720 18 equal equal JJ cord-015021-pol2qm74 2720 19 affinity affinity NN cord-015021-pol2qm74 2720 20 as as IN cord-015021-pol2qm74 2720 21 that that DT cord-015021-pol2qm74 2720 22 of of IN cord-015021-pol2qm74 2720 23 bona bona FW cord-015021-pol2qm74 2720 24 fide fide FW cord-015021-pol2qm74 2720 25 IL il NN cord-015021-pol2qm74 2720 26 - - HYPH cord-015021-pol2qm74 2720 27 I I NNP cord-015021-pol2qm74 2720 28 ; ; : cord-015021-pol2qm74 2720 29 however however RB cord-015021-pol2qm74 2720 30 , , , cord-015021-pol2qm74 2720 31 IL-1Ra IL-1Ra NNP cord-015021-pol2qm74 2720 32 does do VBZ cord-015021-pol2qm74 2720 33 not not RB cord-015021-pol2qm74 2720 34 transduce transduce VB cord-015021-pol2qm74 2720 35 a a DT cord-015021-pol2qm74 2720 36 signal signal NN cord-015021-pol2qm74 2720 37 . . . cord-015021-pol2qm74 2721 1 IL-1Ra il-1ra NN cord-015021-pol2qm74 2721 2 has have VBZ cord-015021-pol2qm74 2721 3 been be VBN cord-015021-pol2qm74 2721 4 given give VBN cord-015021-pol2qm74 2721 5 to to IN cord-015021-pol2qm74 2721 6 humans human NNS cord-015021-pol2qm74 2721 7 in in IN cord-015021-pol2qm74 2721 8 pharmacologic pharmacologic JJ cord-015021-pol2qm74 2721 9 levels level NNS cord-015021-pol2qm74 2721 10 ( ( -LRB- cord-015021-pol2qm74 2721 11 mean mean VB cord-015021-pol2qm74 2721 12 plasma plasma NN cord-015021-pol2qm74 2721 13 levels level NNS cord-015021-pol2qm74 2721 14 of of IN cord-015021-pol2qm74 2721 15 30gg 30gg NN cord-015021-pol2qm74 2721 16 / / SYM cord-015021-pol2qm74 2721 17 ml ml NN cord-015021-pol2qm74 2721 18 ) ) -RRB- cord-015021-pol2qm74 2721 19 without without IN cord-015021-pol2qm74 2721 20 evidence evidence NN cord-015021-pol2qm74 2721 21 of of IN cord-015021-pol2qm74 2721 22 agonist agonist NN cord-015021-pol2qm74 2721 23 activity activity NN cord-015021-pol2qm74 2721 24 . . . cord-015021-pol2qm74 2722 1 In in IN cord-015021-pol2qm74 2722 2 addition addition NN cord-015021-pol2qm74 2722 3 , , , cord-015021-pol2qm74 2722 4 there there EX cord-015021-pol2qm74 2722 5 has have VBZ cord-015021-pol2qm74 2722 6 been be VBN cord-015021-pol2qm74 2722 7 no no DT cord-015021-pol2qm74 2722 8 affect affect NN cord-015021-pol2qm74 2722 9 on on IN cord-015021-pol2qm74 2722 10 normal normal JJ cord-015021-pol2qm74 2722 11 homeostatic homeostatic JJ cord-015021-pol2qm74 2722 12 parameters parameter NNS cord-015021-pol2qm74 2722 13 , , , cord-015021-pol2qm74 2722 14 suggesting suggest VBG cord-015021-pol2qm74 2722 15 that that IN cord-015021-pol2qm74 2722 16 IL IL NNP cord-015021-pol2qm74 2722 17 - - : cord-015021-pol2qm74 2722 18 I -PRON- PRP cord-015021-pol2qm74 2722 19 does do VBZ cord-015021-pol2qm74 2722 20 not not RB cord-015021-pol2qm74 2722 21 play play VB cord-015021-pol2qm74 2722 22 a a DT cord-015021-pol2qm74 2722 23 role role NN cord-015021-pol2qm74 2722 24 in in IN cord-015021-pol2qm74 2722 25 health health NN cord-015021-pol2qm74 2722 26 . . . cord-015021-pol2qm74 2723 1 In in IN cord-015021-pol2qm74 2723 2 healthy healthy JJ cord-015021-pol2qm74 2723 3 humans human NNS cord-015021-pol2qm74 2723 4 given give VBN cord-015021-pol2qm74 2723 5 intravenous intravenous JJ cord-015021-pol2qm74 2723 6 endotoxin endotoxin NN cord-015021-pol2qm74 2723 7 , , , cord-015021-pol2qm74 2723 8 IL IL NNP cord-015021-pol2qm74 2723 9 - - HYPH cord-015021-pol2qm74 2723 10 IRa IRa NNP cord-015021-pol2qm74 2723 11 reduced reduce VBD cord-015021-pol2qm74 2723 12 endotoxin endotoxin NN cord-015021-pol2qm74 2723 13 - - HYPH cord-015021-pol2qm74 2723 14 associated associate VBN cord-015021-pol2qm74 2723 15 neutrophilia neutrophilia NNS cord-015021-pol2qm74 2723 16 by by IN cord-015021-pol2qm74 2723 17 50 50 CD cord-015021-pol2qm74 2723 18 % % NN cord-015021-pol2qm74 2723 19 and and CC cord-015021-pol2qm74 2723 20 completely completely RB cord-015021-pol2qm74 2723 21 reversed reverse VBN cord-015021-pol2qm74 2723 22 endoloxin endoloxin JJ cord-015021-pol2qm74 2723 23 - - HYPH cord-015021-pol2qm74 2723 24 iuduced iuduced JJ cord-015021-pol2qm74 2723 25 immunosuppression immunosuppression NN cord-015021-pol2qm74 2723 26 , , , cord-015021-pol2qm74 2723 27 IL IL NNP cord-015021-pol2qm74 2723 28 - - HYPH cord-015021-pol2qm74 2723 29 tRa tRa NNP cord-015021-pol2qm74 2723 30 is be VBZ cord-015021-pol2qm74 2723 31 produced produce VBN cord-015021-pol2qm74 2723 32 naturally naturally RB cord-015021-pol2qm74 2723 33 and and CC cord-015021-pol2qm74 2723 34 is be VBZ cord-015021-pol2qm74 2723 35 elevated elevate VBN cord-015021-pol2qm74 2723 36 in in IN cord-015021-pol2qm74 2723 37 the the DT cord-015021-pol2qm74 2723 38 circulation circulation NN cord-015021-pol2qm74 2723 39 in in IN cord-015021-pol2qm74 2723 40 several several JJ cord-015021-pol2qm74 2723 41 diseases disease NNS cord-015021-pol2qm74 2723 42 . . . cord-015021-pol2qm74 2724 1 In in IN cord-015021-pol2qm74 2724 2 a a DT cord-015021-pol2qm74 2724 3 variety variety NN cord-015021-pol2qm74 2724 4 of of IN cord-015021-pol2qm74 2724 5 diseases disease NNS cord-015021-pol2qm74 2724 6 , , , cord-015021-pol2qm74 2724 7 plasma plasma NN cord-015021-pol2qm74 2724 8 levels level NNS cord-015021-pol2qm74 2724 9 of of IN cord-015021-pol2qm74 2724 10 IL-1Ra IL-1Ra NNP cord-015021-pol2qm74 2724 11 are be VBP cord-015021-pol2qm74 2724 12 in in IN cord-015021-pol2qm74 2724 13 100-fold 100-fold CD cord-015021-pol2qm74 2724 14 molar molar JJ cord-015021-pol2qm74 2724 15 excess excess NN cord-015021-pol2qm74 2724 16 to to IN cord-015021-pol2qm74 2724 17 those those DT cord-015021-pol2qm74 2724 18 of of IN cord-015021-pol2qm74 2724 19 IL IL NNP cord-015021-pol2qm74 2724 20 - - : cord-015021-pol2qm74 2724 21 I I NNP cord-015021-pol2qm74 2724 22 [ [ -LRB- cord-015021-pol2qm74 2724 23 3 3 CD cord-015021-pol2qm74 2724 24 . . . cord-015021-pol2qm74 2725 1 It -PRON- PRP cord-015021-pol2qm74 2725 2 is be VBZ cord-015021-pol2qm74 2725 3 unclear unclear JJ cord-015021-pol2qm74 2725 4 whether whether IN cord-015021-pol2qm74 2725 5 these these DT cord-015021-pol2qm74 2725 6 endogenous endogenous JJ cord-015021-pol2qm74 2725 7 levels level NNS cord-015021-pol2qm74 2725 8 of of IN cord-015021-pol2qm74 2725 9 IL-1Ra IL-1Ra NNP cord-015021-pol2qm74 2725 10 are be VBP cord-015021-pol2qm74 2725 11 sufficient sufficient JJ cord-015021-pol2qm74 2725 12 to to TO cord-015021-pol2qm74 2725 13 block block VB cord-015021-pol2qm74 2725 14 IL-1 IL-1 NNP cord-015021-pol2qm74 2725 15 activity activity NN cord-015021-pol2qm74 2725 16 in in IN cord-015021-pol2qm74 2725 17 disease disease NN cord-015021-pol2qm74 2725 18 . . . cord-015021-pol2qm74 2726 1 A a DT cord-015021-pol2qm74 2726 2 single single JJ cord-015021-pol2qm74 2726 3 injection injection NN cord-015021-pol2qm74 2726 4 of of IN cord-015021-pol2qm74 2726 5 ] ] -RRB- cord-015021-pol2qm74 2726 6 L-6 L-6 NNP cord-015021-pol2qm74 2726 7 or or CC cord-015021-pol2qm74 2726 8 IFNa IFNa NNS cord-015021-pol2qm74 2726 9 in in IN cord-015021-pol2qm74 2726 10 humans human NNS cord-015021-pol2qm74 2726 11 does do VBZ cord-015021-pol2qm74 2726 12 not not RB cord-015021-pol2qm74 2726 13 induce induce VB cord-015021-pol2qm74 2726 14 IL-1 IL-1 NNP cord-015021-pol2qm74 2726 15 but but CC cord-015021-pol2qm74 2726 16 rather rather RB cord-015021-pol2qm74 2726 17 high high JJ cord-015021-pol2qm74 2726 18 levels level NNS cord-015021-pol2qm74 2726 19 of of IN cord-015021-pol2qm74 2726 20 IL-1Ra IL-1Ra NNP cord-015021-pol2qm74 2726 21 ( ( -LRB- cord-015021-pol2qm74 2726 22 10ng 10ng NNP cord-015021-pol2qm74 2726 23 / / SYM cord-015021-pol2qm74 2726 24 ml ml NN cord-015021-pol2qm74 2726 25 ) ) -RRB- cord-015021-pol2qm74 2726 26 . . . cord-015021-pol2qm74 2727 1 Prof.dr Prof.dr NNP cord-015021-pol2qm74 2727 2 . . . cord-015021-pol2qm74 2728 1 L.A. L.A. NNP cord-015021-pol2qm74 2728 2 Aarden Aarden NNP cord-015021-pol2qm74 2728 3 Interleukin Interleukin NNP cord-015021-pol2qm74 2728 4 6 6 CD cord-015021-pol2qm74 2728 5 ( ( -LRB- cord-015021-pol2qm74 2728 6 IL6 il6 NN cord-015021-pol2qm74 2728 7 ) ) -RRB- cord-015021-pol2qm74 2728 8 is be VBZ cord-015021-pol2qm74 2728 9 a a DT cord-015021-pol2qm74 2728 10 multifunctionaI multifunctionaI NNP cord-015021-pol2qm74 2728 11 cytokine cytokine NN cord-015021-pol2qm74 2728 12 with with IN cord-015021-pol2qm74 2728 13 a a DT cord-015021-pol2qm74 2728 14 central central JJ cord-015021-pol2qm74 2728 15 role role NN cord-015021-pol2qm74 2728 16 in in IN cord-015021-pol2qm74 2728 17 host host NN cord-015021-pol2qm74 2728 18 defense defense NN cord-015021-pol2qm74 2728 19 mechanisms mechanism NNS cord-015021-pol2qm74 2728 20 and and CC cord-015021-pol2qm74 2728 21 consequently consequently RB cord-015021-pol2qm74 2728 22 in in IN cord-015021-pol2qm74 2728 23 inflammation inflammation NN cord-015021-pol2qm74 2728 24 . . . cord-015021-pol2qm74 2729 1 IL6 IL6 NNP cord-015021-pol2qm74 2729 2 is be VBZ cord-015021-pol2qm74 2729 3 thought think VBN cord-015021-pol2qm74 2729 4 to to TO cord-015021-pol2qm74 2729 5 be be VB cord-015021-pol2qm74 2729 6 involved involve VBN cord-015021-pol2qm74 2729 7 in in IN cord-015021-pol2qm74 2729 8 the the DT cord-015021-pol2qm74 2729 9 pathogenesis pathogenesis NN cord-015021-pol2qm74 2729 10 of of IN cord-015021-pol2qm74 2729 11 various various JJ cord-015021-pol2qm74 2729 12 diseases disease NNS cord-015021-pol2qm74 2729 13 . . . cord-015021-pol2qm74 2730 1 Therefore therefore RB cord-015021-pol2qm74 2730 2 , , , cord-015021-pol2qm74 2730 3 specific specific JJ cord-015021-pol2qm74 2730 4 inhibitors inhibitor NNS cord-015021-pol2qm74 2730 5 could could MD cord-015021-pol2qm74 2730 6 have have VB cord-015021-pol2qm74 2730 7 therapeutic therapeutic JJ cord-015021-pol2qm74 2730 8 value value NN cord-015021-pol2qm74 2730 9 . . . cord-015021-pol2qm74 2731 1 A a DT cord-015021-pol2qm74 2731 2 human human JJ cord-015021-pol2qm74 2731 3 - - HYPH cord-015021-pol2qm74 2731 4 mouse mouse NN cord-015021-pol2qm74 2731 5 chimeric chimeric JJ cord-015021-pol2qm74 2731 6 monoclonal monoclonal JJ cord-015021-pol2qm74 2731 7 antibody antibody NN cord-015021-pol2qm74 2731 8 to to IN cord-015021-pol2qm74 2731 9 IL6 IL6 NNP cord-015021-pol2qm74 2731 10 has have VBZ cord-015021-pol2qm74 2731 11 been be VBN cord-015021-pol2qm74 2731 12 applied apply VBN cord-015021-pol2qm74 2731 13 in in IN cord-015021-pol2qm74 2731 14 a a DT cord-015021-pol2qm74 2731 15 phaseI phaseI NNP cord-015021-pol2qm74 2731 16 clinical clinical JJ cord-015021-pol2qm74 2731 17 trial trial NN cord-015021-pol2qm74 2731 18 in in IN cord-015021-pol2qm74 2731 19 patients patient NNS cord-015021-pol2qm74 2731 20 with with IN cord-015021-pol2qm74 2731 21 multiple multiple JJ cord-015021-pol2qm74 2731 22 myeloma myeloma NN cord-015021-pol2qm74 2731 23 and and CC cord-015021-pol2qm74 2731 24 in in IN cord-015021-pol2qm74 2731 25 primate primate JJ cord-015021-pol2qm74 2731 26 models model NNS cord-015021-pol2qm74 2731 27 of of IN cord-015021-pol2qm74 2731 28 sepsis sepsis NN cord-015021-pol2qm74 2731 29 . . . cord-015021-pol2qm74 2732 1 No no DT cord-015021-pol2qm74 2732 2 toxicity toxicity NN cord-015021-pol2qm74 2732 3 was be VBD cord-015021-pol2qm74 2732 4 observed observe VBN cord-015021-pol2qm74 2732 5 and and CC cord-015021-pol2qm74 2732 6 the the DT cord-015021-pol2qm74 2732 7 most most RBS cord-015021-pol2qm74 2732 8 remarkable remarkable JJ cord-015021-pol2qm74 2732 9 outcome outcome NN cord-015021-pol2qm74 2732 10 of of IN cord-015021-pol2qm74 2732 11 this this DT cord-015021-pol2qm74 2732 12 study study NN cord-015021-pol2qm74 2732 13 was be VBD cord-015021-pol2qm74 2732 14 the the DT cord-015021-pol2qm74 2732 15 build build NN cord-015021-pol2qm74 2732 16 up up RP cord-015021-pol2qm74 2732 17 in in IN cord-015021-pol2qm74 2732 18 the the DT cord-015021-pol2qm74 2732 19 circulation circulation NN cord-015021-pol2qm74 2732 20 of of IN cord-015021-pol2qm74 2732 21 IL6-anti IL6-anti NNP cord-015021-pol2qm74 2732 22 - - HYPH cord-015021-pol2qm74 2732 23 IL6 il6 NN cord-015021-pol2qm74 2732 24 complexes complex NNS cord-015021-pol2qm74 2732 25 , , , cord-015021-pol2qm74 2732 26 suggesting suggest VBG cord-015021-pol2qm74 2732 27 that that IN cord-015021-pol2qm74 2732 28 plasma plasma NN cord-015021-pol2qm74 2732 29 IL6 il6 NN cord-015021-pol2qm74 2732 30 measurements measurement NNS cord-015021-pol2qm74 2732 31 represent represent VBP cord-015021-pol2qm74 2732 32 a a DT cord-015021-pol2qm74 2732 33 gross gross JJ cord-015021-pol2qm74 2732 34 underestimation underestimation NN cord-015021-pol2qm74 2732 35 of of IN cord-015021-pol2qm74 2732 36 IL6 il6 NN cord-015021-pol2qm74 2732 37 production production NN cord-015021-pol2qm74 2732 38 in in IN cord-015021-pol2qm74 2732 39 the the DT cord-015021-pol2qm74 2732 40 patient patient NN cord-015021-pol2qm74 2732 41 . . . cord-015021-pol2qm74 2733 1 Until until IN cord-015021-pol2qm74 2733 2 now now RB cord-015021-pol2qm74 2733 3 no no DT cord-015021-pol2qm74 2733 4 natural natural JJ cord-015021-pol2qm74 2733 5 antagonists antagonist NNS cord-015021-pol2qm74 2733 6 of of IN cord-015021-pol2qm74 2733 7 IL6 IL6 NNP cord-015021-pol2qm74 2733 8 have have VBP cord-015021-pol2qm74 2733 9 been be VBN cord-015021-pol2qm74 2733 10 described describe VBN cord-015021-pol2qm74 2733 11 . . . cord-015021-pol2qm74 2734 1 The the DT cord-015021-pol2qm74 2734 2 biological biological JJ cord-015021-pol2qm74 2734 3 activities activity NNS cord-015021-pol2qm74 2734 4 of of IN cord-015021-pol2qm74 2734 5 IL6 il6 NN cord-015021-pol2qm74 2734 6 results result VBZ cord-015021-pol2qm74 2734 7 from from IN cord-015021-pol2qm74 2734 8 binding bind VBG cord-015021-pol2qm74 2734 9 to to IN cord-015021-pol2qm74 2734 10 a a DT cord-015021-pol2qm74 2734 11 lowaffinity lowaffinity NN cord-015021-pol2qm74 2734 12 IL6-receptor il6-receptor NN cord-015021-pol2qm74 2734 13 ( ( -LRB- cord-015021-pol2qm74 2734 14 IL6R il6r NN cord-015021-pol2qm74 2734 15 ) ) -RRB- cord-015021-pol2qm74 2734 16 . . . cord-015021-pol2qm74 2735 1 The the DT cord-015021-pol2qm74 2735 2 IL6 IL6 NNP cord-015021-pol2qm74 2735 3 / / SYM cord-015021-pol2qm74 2735 4 IL6R IL6R NNP cord-015021-pol2qm74 2735 5 complex complex NN cord-015021-pol2qm74 2735 6 induces induce VBZ cord-015021-pol2qm74 2735 7 disulfide disulfide RB cord-015021-pol2qm74 2735 8 - - HYPH cord-015021-pol2qm74 2735 9 linked link VBN cord-015021-pol2qm74 2735 10 homodimerization homodimerization NN cord-015021-pol2qm74 2735 11 of of IN cord-015021-pol2qm74 2735 12 the the DT cord-015021-pol2qm74 2735 13 signal signal NN cord-015021-pol2qm74 2735 14 transducing transduce VBG cord-015021-pol2qm74 2735 15 receptor receptor NN cord-015021-pol2qm74 2735 16 component component NN cord-015021-pol2qm74 2735 17 , , , cord-015021-pol2qm74 2735 18 gp130 gp130 NNS cord-015021-pol2qm74 2735 19 . . . cord-015021-pol2qm74 2736 1 Studies study NNS cord-015021-pol2qm74 2736 2 on on IN cord-015021-pol2qm74 2736 3 the the DT cord-015021-pol2qm74 2736 4 structure structure NN cord-015021-pol2qm74 2736 5 - - HYPH cord-015021-pol2qm74 2736 6 function function NN cord-015021-pol2qm74 2736 7 relation relation NN cord-015021-pol2qm74 2736 8 of of IN cord-015021-pol2qm74 2736 9 IL6 il6 NN cord-015021-pol2qm74 2736 10 revealed reveal VBD cord-015021-pol2qm74 2736 11 that that IN cord-015021-pol2qm74 2736 12 disruption disruption NN cord-015021-pol2qm74 2736 13 of of IN cord-015021-pol2qm74 2736 14 the the DT cord-015021-pol2qm74 2736 15 gpl30-interaction gpl30-interaction NN cord-015021-pol2qm74 2736 16 site site NN cord-015021-pol2qm74 2736 17 on on IN cord-015021-pol2qm74 2736 18 IL6 IL6 NNP cord-015021-pol2qm74 2736 19 gives give VBZ cord-015021-pol2qm74 2736 20 rise rise NN cord-015021-pol2qm74 2736 21 to to IN cord-015021-pol2qm74 2736 22 a a DT cord-015021-pol2qm74 2736 23 mutant mutant JJ cord-015021-pol2qm74 2736 24 IL6 il6 NN cord-015021-pol2qm74 2736 25 that that IN cord-015021-pol2qm74 2736 26 , , , cord-015021-pol2qm74 2736 27 by by IN cord-015021-pol2qm74 2736 28 virtue virtue NN cord-015021-pol2qm74 2736 29 of of IN cord-015021-pol2qm74 2736 30 its -PRON- PRP$ cord-015021-pol2qm74 2736 31 intact intact JJ cord-015021-pol2qm74 2736 32 binding bind VBG cord-015021-pol2qm74 2736 33 to to IN cord-015021-pol2qm74 2736 34 the the DT cord-015021-pol2qm74 2736 35 IL6R il6r NN cord-015021-pol2qm74 2736 36 , , , cord-015021-pol2qm74 2736 37 acts act VBZ cord-015021-pol2qm74 2736 38 as as IN cord-015021-pol2qm74 2736 39 a a DT cord-015021-pol2qm74 2736 40 potent potent JJ cord-015021-pol2qm74 2736 41 antagonist antagonist NN cord-015021-pol2qm74 2736 42 on on IN cord-015021-pol2qm74 2736 43 human human JJ cord-015021-pol2qm74 2736 44 hepatocytes hepatocyte NNS cord-015021-pol2qm74 2736 45 and and CC cord-015021-pol2qm74 2736 46 on on IN cord-015021-pol2qm74 2736 47 human human JJ cord-015021-pol2qm74 2736 48 B b NN cord-015021-pol2qm74 2736 49 cells cell NNS cord-015021-pol2qm74 2736 50 . . . cord-015021-pol2qm74 2737 1 In in IN cord-015021-pol2qm74 2737 2 vivo vivo NN cord-015021-pol2qm74 2737 3 studies study NNS cord-015021-pol2qm74 2737 4 using use VBG cord-015021-pol2qm74 2737 5 this this DT cord-015021-pol2qm74 2737 6 molecule molecule NN cord-015021-pol2qm74 2737 7 will will MD cord-015021-pol2qm74 2737 8 be be VB cord-015021-pol2qm74 2737 9 initiated initiate VBN cord-015021-pol2qm74 2737 10 in in IN cord-015021-pol2qm74 2737 11 the the DT cord-015021-pol2qm74 2737 12 near near JJ cord-015021-pol2qm74 2737 13 future future NN cord-015021-pol2qm74 2737 14 . . . cord-015021-pol2qm74 2738 1 The the DT cord-015021-pol2qm74 2738 2 evolution evolution NN cord-015021-pol2qm74 2738 3 of of IN cord-015021-pol2qm74 2738 4 infla infla NNP cord-015021-pol2qm74 2738 5 ~ ~ NFP cord-015021-pol2qm74 2738 6 ation ation NN cord-015021-pol2qm74 2738 7 involves involve VBZ cord-015021-pol2qm74 2738 8 a a DT cord-015021-pol2qm74 2738 9 dynamic dynamic JJ cord-015021-pol2qm74 2738 10 series series NN cord-015021-pol2qm74 2738 11 of of IN cord-015021-pol2qm74 2738 12 cellular cellular JJ cord-015021-pol2qm74 2738 13 events event NNS cord-015021-pol2qm74 2738 14 controlled control VBN cord-015021-pol2qm74 2738 15 by by IN cord-015021-pol2qm74 2738 16 specific specific JJ cord-015021-pol2qm74 2738 17 signals signal NNS cord-015021-pol2qm74 2738 18 which which WDT cord-015021-pol2qm74 2738 19 are be VBP cord-015021-pol2qm74 2738 20 important important JJ cord-015021-pol2qm74 2738 21 to to IN cord-015021-pol2qm74 2738 22 the the DT cord-015021-pol2qm74 2738 23 initiation initiation NN cord-015021-pol2qm74 2738 24 , , , cord-015021-pol2qm74 2738 25 maintenance maintenance NN cord-015021-pol2qm74 2738 26 , , , cord-015021-pol2qm74 2738 27 and and CC cord-015021-pol2qm74 2738 28 final final JJ cord-015021-pol2qm74 2738 29 resolution resolution NN cord-015021-pol2qm74 2738 30 of of IN cord-015021-pol2qm74 2738 31 the the DT cord-015021-pol2qm74 2738 32 inflammatory inflammatory JJ cord-015021-pol2qm74 2738 33 response response NN cord-015021-pol2qm74 2738 34 . . . cord-015021-pol2qm74 2739 1 The the DT cord-015021-pol2qm74 2739 2 various various JJ cord-015021-pol2qm74 2739 3 phases phase NNS cord-015021-pol2qm74 2739 4 of of IN cord-015021-pol2qm74 2739 5 inflammation inflammation NN cord-015021-pol2qm74 2739 6 are be VBP cord-015021-pol2qm74 2739 7 influenced influence VBN cord-015021-pol2qm74 2739 8 via via IN cord-015021-pol2qm74 2739 9 the the DT cord-015021-pol2qm74 2739 10 expression expression NN cord-015021-pol2qm74 2739 11 and and CC cord-015021-pol2qm74 2739 12 subsequent subsequent JJ cord-015021-pol2qm74 2739 13 regulation regulation NN cord-015021-pol2qm74 2739 14 of of IN cord-015021-pol2qm74 2739 15 a a DT cord-015021-pol2qm74 2739 16 number number NN cord-015021-pol2qm74 2739 17 of of IN cord-015021-pol2qm74 2739 18 key key JJ cord-015021-pol2qm74 2739 19 mediators mediator NNS cord-015021-pol2qm74 2739 20 which which WDT cord-015021-pol2qm74 2739 21 play play VBP cord-015021-pol2qm74 2739 22 a a DT cord-015021-pol2qm74 2739 23 predominant predominant JJ cord-015021-pol2qm74 2739 24 role role NN cord-015021-pol2qm74 2739 25 during during IN cord-015021-pol2qm74 2739 26 each each DT cord-015021-pol2qm74 2739 27 particular particular JJ cord-015021-pol2qm74 2739 28 stage stage NN cord-015021-pol2qm74 2739 29 of of IN cord-015021-pol2qm74 2739 30 the the DT cord-015021-pol2qm74 2739 31 developing develop VBG cord-015021-pol2qm74 2739 32 lesion lesion NN cord-015021-pol2qm74 2739 33 . . . cord-015021-pol2qm74 2740 1 For for IN cord-015021-pol2qm74 2740 2 example example NN cord-015021-pol2qm74 2740 3 , , , cord-015021-pol2qm74 2740 4 the the DT cord-015021-pol2qm74 2740 5 initial initial JJ cord-015021-pol2qm74 2740 6 elicitation elicitation NN cord-015021-pol2qm74 2740 7 of of IN cord-015021-pol2qm74 2740 8 blood blood NN cord-015021-pol2qm74 2740 9 born bear VBN cord-015021-pol2qm74 2740 10 leukocytes leukocyte NNS cord-015021-pol2qm74 2740 11 to to IN cord-015021-pol2qm74 2740 12 on on IN cord-015021-pol2qm74 2740 13 inflamed inflamed JJ cord-015021-pol2qm74 2740 14 area area NN cord-015021-pol2qm74 2740 15 is be VBZ cord-015021-pol2qm74 2740 16 a a DT cord-015021-pol2qm74 2740 17 complex complex JJ cord-015021-pol2qm74 2740 18 system system NN cord-015021-pol2qm74 2740 19 that that WDT cord-015021-pol2qm74 2740 20 is be VBZ cord-015021-pol2qm74 2740 21 dependent dependent JJ cord-015021-pol2qm74 2740 22 upon upon IN cord-015021-pol2qm74 2740 23 the the DT cord-015021-pol2qm74 2740 24 expression expression NN cord-015021-pol2qm74 2740 25 of of IN cord-015021-pol2qm74 2740 26 early early JJ cord-015021-pol2qm74 2740 27 response response NN cord-015021-pol2qm74 2740 28 cytokineSo cytokineSo NFP cord-015021-pol2qm74 2740 29 These these DT cord-015021-pol2qm74 2740 30 proximal proximal JJ cord-015021-pol2qm74 2740 31 mediators mediator NNS cord-015021-pol2qm74 2740 32 , , , cord-015021-pol2qm74 2740 33 including include VBG cord-015021-pol2qm74 2740 34 both both CC cord-015021-pol2qm74 2740 35 interleukin interleukin NN cord-015021-pol2qm74 2740 36 - - : cord-015021-pol2qm74 2740 37 i i JJ cord-015021-pol2qm74 2740 38 ( ( -LRB- cord-015021-pol2qm74 2740 39 IL IL NNP cord-015021-pol2qm74 2740 40 - - HYPH cord-015021-pol2qm74 2740 41 I I NNP cord-015021-pol2qm74 2740 42 ) ) -RRB- cord-015021-pol2qm74 2740 43 and and CC cord-015021-pol2qm74 2740 44 tumor tumor NN cord-015021-pol2qm74 2740 45 necroisis necroisis NN cord-015021-pol2qm74 2740 46 factor factor NN cord-015021-pol2qm74 2740 47 ( ( -LRB- cord-015021-pol2qm74 2740 48 TNF TNF NNP cord-015021-pol2qm74 2740 49 ) ) -RRB- cord-015021-pol2qm74 2740 50 , , , cord-015021-pol2qm74 2740 51 are be VBP cord-015021-pol2qm74 2740 52 important important JJ cord-015021-pol2qm74 2740 53 in in IN cord-015021-pol2qm74 2740 54 the the DT cord-015021-pol2qm74 2740 55 initiation initiation NN cord-015021-pol2qm74 2740 56 phase phase NN cord-015021-pol2qm74 2740 57 by by IN cord-015021-pol2qm74 2740 58 activating activate VBG cord-015021-pol2qm74 2740 59 both both DT cord-015021-pol2qm74 2740 60 immune immune JJ cord-015021-pol2qm74 2740 61 and and CC cord-015021-pol2qm74 2740 62 non non JJ cord-015021-pol2qm74 2740 63 - - JJ cord-015021-pol2qm74 2740 64 immune immune JJ cord-015021-pol2qm74 2740 65 cells cell NNS cord-015021-pol2qm74 2740 66 and and CC cord-015021-pol2qm74 2740 67 establishing establish VBG cord-015021-pol2qm74 2740 68 a a DT cord-015021-pol2qm74 2740 69 series series NN cord-015021-pol2qm74 2740 70 of of IN cord-015021-pol2qm74 2740 71 cytokine cytokine NN cord-015021-pol2qm74 2740 72 networks network NNS cord-015021-pol2qm74 2740 73 , , , cord-015021-pol2qm74 2740 74 Thus thus RB cord-015021-pol2qm74 2740 75 , , , cord-015021-pol2qm74 2740 76 the the DT cord-015021-pol2qm74 2740 77 above above JJ cord-015021-pol2qm74 2740 78 proximal proximal JJ cord-015021-pol2qm74 2740 79 mediators mediator NNS cord-015021-pol2qm74 2740 80 can can MD cord-015021-pol2qm74 2740 81 stimulate stimulate VB cord-015021-pol2qm74 2740 82 endothelial endothelial JJ cord-015021-pol2qm74 2740 83 cells cell NNS cord-015021-pol2qm74 2740 84 , , , cord-015021-pol2qm74 2740 85 epithelial epithelial JJ cord-015021-pol2qm74 2740 86 cells cell NNS cord-015021-pol2qm74 2740 87 , , , cord-015021-pol2qm74 2740 88 smooth smooth JJ cord-015021-pol2qm74 2740 89 muscle muscle NN cord-015021-pol2qm74 2740 90 cells cell NNS cord-015021-pol2qm74 2740 91 , , , cord-015021-pol2qm74 2740 92 and and CC cord-015021-pol2qm74 2740 93 fibroblasts fibroblast NNS cord-015021-pol2qm74 2740 94 to to TO cord-015021-pol2qm74 2740 95 generate generate VB cord-015021-pol2qm74 2740 96 more more JJR cord-015021-pol2qm74 2740 97 distal distal JJ cord-015021-pol2qm74 2740 98 cytokines cytokine NNS cord-015021-pol2qm74 2740 99 . . . cord-015021-pol2qm74 2741 1 These these DT cord-015021-pol2qm74 2741 2 latter latter JJ cord-015021-pol2qm74 2741 3 cytokines cytokine NNS cord-015021-pol2qm74 2741 4 include include VBP cord-015021-pol2qm74 2741 5 interleukin-8 interleukin-8 NNP cord-015021-pol2qm74 2741 6 ( ( -LRB- cord-015021-pol2qm74 2741 7 IL-8 IL-8 NNP cord-015021-pol2qm74 2741 8 ) ) -RRB- cord-015021-pol2qm74 2741 9 , , , cord-015021-pol2qm74 2741 10 macrophage macrophage NN cord-015021-pol2qm74 2741 11 inflammatory inflammatory JJ cord-015021-pol2qm74 2741 12 protein protein NN cord-015021-pol2qm74 2741 13 - - : cord-015021-pol2qm74 2741 14 i i NNP cord-015021-pol2qm74 2741 15 ( ( -LRB- cord-015021-pol2qm74 2741 16 MIP MIP NNP cord-015021-pol2qm74 2741 17 - - HYPH cord-015021-pol2qm74 2741 18 I I NNP cord-015021-pol2qm74 2741 19 ) ) -RRB- cord-015021-pol2qm74 2741 20 , , , cord-015021-pol2qm74 2741 21 and and CC cord-015021-pol2qm74 2741 22 monocyte monocyte NNP cord-015021-pol2qm74 2741 23 cbemoattractant cbemoattractant NNP cord-015021-pol2qm74 2741 24 protein protein NNP cord-015021-pol2qm74 2742 1 -i -i NFP cord-015021-pol2qm74 2742 2 ( ( -LRB- cord-015021-pol2qm74 2742 3 MCP MCP NNP cord-015021-pol2qm74 2742 4 - - HYPH cord-015021-pol2qm74 2742 5 I I NNP cord-015021-pol2qm74 2742 6 ) ) -RRB- cord-015021-pol2qm74 2742 7 . . . cord-015021-pol2qm74 2743 1 The the DT cord-015021-pol2qm74 2743 2 importance importance NN cord-015021-pol2qm74 2743 3 of of IN cord-015021-pol2qm74 2743 4 the the DT cord-015021-pol2qm74 2743 5 above above JJ cord-015021-pol2qm74 2743 6 chemukines chemukine NNS cord-015021-pol2qm74 2743 7 can can MD cord-015021-pol2qm74 2743 8 be be VB cord-015021-pol2qm74 2743 9 found find VBN cord-015021-pol2qm74 2743 10 in in IN cord-015021-pol2qm74 2743 11 the the DT cord-015021-pol2qm74 2743 12 role role NN cord-015021-pol2qm74 2743 13 they -PRON- PRP cord-015021-pol2qm74 2743 14 play play VBP cord-015021-pol2qm74 2743 15 in in IN cord-015021-pol2qm74 2743 16 leukocyte leukocyte NN cord-015021-pol2qm74 2743 17 elicitation elicitation NN cord-015021-pol2qm74 2743 18 , , , cord-015021-pol2qm74 2743 19 as as RB cord-015021-pol2qm74 2743 20 well well RB cord-015021-pol2qm74 2743 21 as as IN cord-015021-pol2qm74 2743 22 wound wound NN cord-015021-pol2qm74 2743 23 repair repair NN cord-015021-pol2qm74 2743 24 . . . cord-015021-pol2qm74 2744 1 Numerous numerous JJ cord-015021-pol2qm74 2744 2 investigations investigation NNS cord-015021-pol2qm74 2744 3 have have VBP cord-015021-pol2qm74 2744 4 shown show VBN cord-015021-pol2qm74 2744 5 the the DT cord-015021-pol2qm74 2744 6 diverse diverse JJ cord-015021-pol2qm74 2744 7 cellular cellular JJ cord-015021-pol2qm74 2744 8 sources source NNS cord-015021-pol2qm74 2744 9 of of IN cord-015021-pol2qm74 2744 10 IL-8 IL-8 NNP cord-015021-pol2qm74 2744 11 and and CC cord-015021-pol2qm74 2744 12 the the DT cord-015021-pol2qm74 2744 13 ability ability NN cord-015021-pol2qm74 2744 14 of of IN cord-015021-pol2qm74 2744 15 IL-8 IL-8 NNP cord-015021-pol2qm74 2744 16 to to TO cord-015021-pol2qm74 2744 17 elicit elicit VB cord-015021-pol2qm74 2744 18 neutrophils neutrophil NNS cord-015021-pol2qm74 2744 19 in in IN cord-015021-pol2qm74 2744 20 vitro vitro FW cord-015021-pol2qm74 2744 21 at at IN cord-015021-pol2qm74 2744 22 pM pm NN cord-015021-pol2qm74 2744 23 to to IN cord-015021-pol2qm74 2744 24 nM nm CD cord-015021-pol2qm74 2744 25 concentrations concentration NNS cord-015021-pol2qm74 2744 26 , , , cord-015021-pol2qm74 2744 27 however however RB cord-015021-pol2qm74 2744 28 , , , cord-015021-pol2qm74 2744 29 recent recent JJ cord-015021-pol2qm74 2744 30 studies study NNS cord-015021-pol2qm74 2744 31 have have VBP cord-015021-pol2qm74 2744 32 sho%~ sho%~ CD cord-015021-pol2qm74 2744 33 an an DT cord-015021-pol2qm74 2744 34 additional additional JJ cord-015021-pol2qm74 2744 35 role role NN cord-015021-pol2qm74 2744 36 for for IN cord-015021-pol2qm74 2744 37 IL-8 IL-8 NNP cord-015021-pol2qm74 2744 38 during during IN cord-015021-pol2qm74 2744 39 the the DT cord-015021-pol2qm74 2744 40 resolution resolution NN cord-015021-pol2qm74 2744 41 phase phase NN cord-015021-pol2qm74 2744 42 of of IN cord-015021-pol2qm74 2744 43 the the DT cord-015021-pol2qm74 2744 44 inflammatory inflammatory JJ cord-015021-pol2qm74 2744 45 process process NN cord-015021-pol2qm74 2744 46 . . . cord-015021-pol2qm74 2745 1 Using use VBG cord-015021-pol2qm74 2745 2 corneal corneal JJ cord-015021-pol2qm74 2745 3 pocket pocket NN cord-015021-pol2qm74 2745 4 animal animal NN cord-015021-pol2qm74 2745 5 models model NNS cord-015021-pol2qm74 2745 6 of of IN cord-015021-pol2qm74 2745 7 angiogenesis angiogenesis NN cord-015021-pol2qm74 2745 8 / / SYM cord-015021-pol2qm74 2745 9 neovascularization neovascularization NN cord-015021-pol2qm74 2745 10 , , , cord-015021-pol2qm74 2745 11 IL-8 IL-8 NNP cord-015021-pol2qm74 2745 12 was be VBD cord-015021-pol2qm74 2745 13 found find VBN cord-015021-pol2qm74 2745 14 to to TO cord-015021-pol2qm74 2745 15 be be VB cord-015021-pol2qm74 2745 16 a a DT cord-015021-pol2qm74 2745 17 potent potent JJ cord-015021-pol2qm74 2745 18 angiogenic angiogenic JJ cord-015021-pol2qm74 2745 19 factor factor NN cord-015021-pol2qm74 2745 20 at at IN cord-015021-pol2qm74 2745 21 concentrations concentration NNS cord-015021-pol2qm74 2745 22 ranging range VBG cord-015021-pol2qm74 2745 23 from from IN cord-015021-pol2qm74 2745 24 2 2 CD cord-015021-pol2qm74 2745 25 - - HYPH cord-015021-pol2qm74 2745 26 40ng 40ng JJ cord-015021-pol2qm74 2745 27 / / SYM cord-015021-pol2qm74 2745 28 ml ml NN cord-015021-pol2qm74 2745 29 . . . cord-015021-pol2qm74 2746 1 Sequential sequential JJ cord-015021-pol2qm74 2746 2 fluorescein fluorescein NNP cord-015021-pol2qm74 2746 3 angiograms angiogram NNS cord-015021-pol2qm74 2746 4 demonstrated demonstrate VBD cord-015021-pol2qm74 2746 5 that that IN cord-015021-pol2qm74 2746 6 IL-8 IL-8 NNP cord-015021-pol2qm74 2746 7 induced induce VBD cord-015021-pol2qm74 2746 8 neovascularization neovascularization NN cord-015021-pol2qm74 2746 9 by by IN cord-015021-pol2qm74 2746 10 14 14 CD cord-015021-pol2qm74 2746 11 days day NNS cord-015021-pol2qm74 2746 12 , , , cord-015021-pol2qm74 2746 13 which which WDT cord-015021-pol2qm74 2746 14 regressed regress VBD cord-015021-pol2qm74 2746 15 by by IN cord-015021-pol2qm74 2746 16 6 6 CD cord-015021-pol2qm74 2746 17 weeks week NNS cord-015021-pol2qm74 2746 18 . . . cord-015021-pol2qm74 2747 1 In in IN cord-015021-pol2qm74 2747 2 further further JJ cord-015021-pol2qm74 2747 3 analyses analysis NNS cord-015021-pol2qm74 2747 4 , , , cord-015021-pol2qm74 2747 5 both both DT cord-015021-pol2qm74 2747 6 conditioned condition VBN cord-015021-pol2qm74 2747 7 media medium NNS cord-015021-pol2qm74 2747 8 recovered recover VBD cord-015021-pol2qm74 2747 9 from from IN cord-015021-pol2qm74 2747 10 either either CC cord-015021-pol2qm74 2747 11 inflamed inflamed JJ cord-015021-pol2qm74 2747 12 human human JJ cord-015021-pol2qm74 2747 13 heumatoid heumatoid NN cord-015021-pol2qm74 2747 14 synovial synovial JJ cord-015021-pol2qm74 2747 15 tissue tissue NN cord-015021-pol2qm74 2747 16 macrophages macrophage NNS cord-015021-pol2qm74 2747 17 or or CC cord-015021-pol2qm74 2747 18 LPS LPS NNP cord-015021-pol2qm74 2747 19 - - HYPH cord-015021-pol2qm74 2747 20 stimulated stimulate VBN cord-015021-pol2qm74 2747 21 peripheral peripheral JJ cord-015021-pol2qm74 2747 22 blood blood NN cord-015021-pol2qm74 2747 23 monocytes monocyte NNS cord-015021-pol2qm74 2747 24 were be VBD cord-015021-pol2qm74 2747 25 found find VBN cord-015021-pol2qm74 2747 26 to to TO cord-015021-pol2qm74 2747 27 possess possess VB cord-015021-pol2qm74 2747 28 potent potent JJ cord-015021-pol2qm74 2747 29 angiogenic angiogenic JJ cord-015021-pol2qm74 2747 30 activity activity NN cord-015021-pol2qm74 2747 31 , , , cord-015021-pol2qm74 2747 32 which which WDT cord-015021-pol2qm74 2747 33 was be VBD cord-015021-pol2qm74 2747 34 effectively effectively RB cord-015021-pol2qm74 2747 35 blocked block VBN cord-015021-pol2qm74 2747 36 by by IN cord-015021-pol2qm74 2747 37 neutralizing neutralize VBG cord-015021-pol2qm74 2747 38 antibodies antibody NNS cord-015021-pol2qm74 2747 39 directed direct VBN cord-015021-pol2qm74 2747 40 against against IN cord-015021-pol2qm74 2747 41 human human JJ cord-015021-pol2qm74 2747 42 IL-8 il-8 NN cord-015021-pol2qm74 2747 43 . . . cord-015021-pol2qm74 2748 1 In in IN cord-015021-pol2qm74 2748 2 addition addition NN cord-015021-pol2qm74 2748 3 , , , cord-015021-pol2qm74 2748 4 an an DT cord-015021-pol2qm74 2748 5 IL-8 IL-8 NNP cord-015021-pol2qm74 2748 6 antisense antisense NN cord-015021-pol2qm74 2748 7 nligomunclentide nligomunclentide NN cord-015021-pol2qm74 2748 8 blocked block VBD cord-015021-pol2qm74 2748 9 the the DT cord-015021-pol2qm74 2748 10 expression expression NN cord-015021-pol2qm74 2748 11 of of IN cord-015021-pol2qm74 2748 12 a a DT cord-015021-pol2qm74 2748 13 functionally functionally RB cord-015021-pol2qm74 2748 14 active active JJ cord-015021-pol2qm74 2748 15 angiogenic angiogenic JJ cord-015021-pol2qm74 2748 16 factor factor NN cord-015021-pol2qm74 2748 17 from from IN cord-015021-pol2qm74 2748 18 LPS LPS NNP cord-015021-pol2qm74 2748 19 treated treat VBN cord-015021-pol2qm74 2748 20 monocytes monocyte NNS cord-015021-pol2qm74 2748 21 . . . cord-015021-pol2qm74 2749 1 The the DT cord-015021-pol2qm74 2749 2 above above JJ cord-015021-pol2qm74 2749 3 data datum NNS cord-015021-pol2qm74 2749 4 demonstrate demonstrate VBP cord-015021-pol2qm74 2749 5 that that IN cord-015021-pol2qm74 2749 6 IL-8 IL-8 NNP cord-015021-pol2qm74 2749 7 has have VBZ cord-015021-pol2qm74 2749 8 multifumctional multifumctional JJ cord-015021-pol2qm74 2749 9 activities activity NNS cord-015021-pol2qm74 2749 10 during during IN cord-015021-pol2qm74 2749 11 the the DT cord-015021-pol2qm74 2749 12 initiation initiation NN cord-015021-pol2qm74 2749 13 , , , cord-015021-pol2qm74 2749 14 maintenance maintenance NN cord-015021-pol2qm74 2749 15 , , , cord-015021-pol2qm74 2749 16 and and CC cord-015021-pol2qm74 2749 17 resolution resolution NN cord-015021-pol2qm74 2749 18 of of IN cord-015021-pol2qm74 2749 19 a a DT cord-015021-pol2qm74 2749 20 local local JJ cord-015021-pol2qm74 2749 21 inflammatory inflammatory JJ cord-015021-pol2qm74 2749 22 response response NN cord-015021-pol2qm74 2749 23 . . . cord-015021-pol2qm74 2750 1 inhibits inhibit VBZ cord-015021-pol2qm74 2750 2 specific specific JJ cord-015021-pol2qm74 2750 3 T t NN cord-015021-pol2qm74 2750 4 - - HYPH cord-015021-pol2qm74 2750 5 cell cell NN cord-015021-pol2qm74 2750 6 responses response NNS cord-015021-pol2qm74 2750 7 to to IN cord-015021-pol2qm74 2750 8 soluble soluble JJ cord-015021-pol2qm74 2750 9 protein protein NN cord-015021-pol2qm74 2750 10 antigens antigen NNS cord-015021-pol2qm74 2750 11 and and CC cord-015021-pol2qm74 2750 12 alloantigens alloantigen NNS cord-015021-pol2qm74 2750 13 . . . cord-015021-pol2qm74 2751 1 The the DT cord-015021-pol2qm74 2751 2 proliferative proliferative JJ cord-015021-pol2qm74 2751 3 responses response NNS cord-015021-pol2qm74 2751 4 of of IN cord-015021-pol2qm74 2751 5 Th0 th0 CD cord-015021-pol2qm74 2751 6 , , , cord-015021-pol2qm74 2751 7 Thl Thl NNP cord-015021-pol2qm74 2751 8 and and CC cord-015021-pol2qm74 2751 9 Th2 th2 CD cord-015021-pol2qm74 2751 10 CD4 CD4 NNP cord-015021-pol2qm74 2751 11 ÷ ÷ NNP cord-015021-pol2qm74 2751 12 T T NNP cord-015021-pol2qm74 2751 13 - - HYPH cord-015021-pol2qm74 2751 14 cell cell NN cord-015021-pol2qm74 2751 15 clones clone NNS cord-015021-pol2qm74 2751 16 and and CC cord-015021-pol2qm74 2751 17 cytokine cytokine NN cord-015021-pol2qm74 2751 18 production production NN cord-015021-pol2qm74 2751 19 by by IN cord-015021-pol2qm74 2751 20 these these DT cord-015021-pol2qm74 2751 21 T t NN cord-015021-pol2qm74 2751 22 - - HYPH cord-015021-pol2qm74 2751 23 cell cell NN cord-015021-pol2qm74 2751 24 subsets subset NNS cord-015021-pol2qm74 2751 25 are be VBP cord-015021-pol2qm74 2751 26 equally equally RB cord-015021-pol2qm74 2751 27 well well RB cord-015021-pol2qm74 2751 28 inhibited inhibited JJ cord-015021-pol2qm74 2751 29 . . . cord-015021-pol2qm74 2752 1 The the DT cord-015021-pol2qm74 2752 2 inhibitory inhibitory JJ cord-015021-pol2qm74 2752 3 effects effect NNS cord-015021-pol2qm74 2752 4 of of IN cord-015021-pol2qm74 2752 5 IL-10 IL-10 NNP cord-015021-pol2qm74 2752 6 are be VBP cord-015021-pol2qm74 2752 7 indirect indirect JJ cord-015021-pol2qm74 2752 8 and and CC cord-015021-pol2qm74 2752 9 related relate VBN cord-015021-pol2qm74 2752 10 to to IN cord-015021-pol2qm74 2752 11 inhibition inhibition NN cord-015021-pol2qm74 2752 12 of of IN cord-015021-pol2qm74 2752 13 antigen antigen NN cord-015021-pol2qm74 2752 14 - - HYPH cord-015021-pol2qm74 2752 15 presenting present VBG cord-015021-pol2qm74 2752 16 capacity capacity NN cord-015021-pol2qm74 2752 17 and and CC cord-015021-pol2qm74 2752 18 accessory accessory NN cord-015021-pol2qm74 2752 19 function function NN cord-015021-pol2qm74 2752 20 of of IN cord-015021-pol2qm74 2752 21 the the DT cord-015021-pol2qm74 2752 22 antigen antigen NN cord-015021-pol2qm74 2752 23 - - HYPH cord-015021-pol2qm74 2752 24 presenting present VBG cord-015021-pol2qm74 2752 25 cells cell NNS cord-015021-pol2qm74 2752 26 ( ( -LRB- cord-015021-pol2qm74 2752 27 APC APC NNP cord-015021-pol2qm74 2752 28 ) ) -RRB- cord-015021-pol2qm74 2752 29 . . . cord-015021-pol2qm74 2753 1 However however RB cord-015021-pol2qm74 2753 2 , , , cord-015021-pol2qm74 2753 3 IL-10 IL-10 NNP cord-015021-pol2qm74 2753 4 also also RB cord-015021-pol2qm74 2753 5 directly directly RB cord-015021-pol2qm74 2753 6 inhibits inhibit VBZ cord-015021-pol2qm74 2753 7 T t NN cord-015021-pol2qm74 2753 8 - - HYPH cord-015021-pol2qm74 2753 9 cell cell NN cord-015021-pol2qm74 2753 10 proli proli NN cord-015021-pol2qm74 2753 11 / / SYM cord-015021-pol2qm74 2753 12 eration eration NN cord-015021-pol2qm74 2753 13 induced induce VBN cord-015021-pol2qm74 2753 14 by by IN cord-015021-pol2qm74 2753 15 cross]inked cross]inked `` cord-015021-pol2qm74 2753 16 anti anti NNP cord-015021-pol2qm74 2753 17 - - JJ cord-015021-pol2qm74 2753 18 CD3 cd3 JJ cord-015021-pol2qm74 2753 19 or or CC cord-015021-pol2qm74 2753 20 anti anti JJ cord-015021-pol2qm74 2753 21 - - NNP cord-015021-pol2qm74 2753 22 CD2 CD2 NNP cord-015021-pol2qm74 2753 23 mAbs mAbs NNP cord-015021-pol2qm74 2754 1 ( ( -LRB- cord-015021-pol2qm74 2754 2 e.g. e.g. RB cord-015021-pol2qm74 2754 3 in in IN cord-015021-pol2qm74 2754 4 the the DT cord-015021-pol2qm74 2754 5 absence absence NN cord-015021-pol2qm74 2754 6 of of IN cord-015021-pol2qm74 2754 7 professional professional JJ cord-015021-pol2qm74 2754 8 APC APC NNP cord-015021-pol2qm74 2754 9 ) ) -RRB- cord-015021-pol2qm74 2754 10 , , , cord-015021-pol2qm74 2754 11 by by IN cord-015021-pol2qm74 2754 12 specifically specifically RB cord-015021-pol2qm74 2754 13 inhibiting inhibit VBG cord-015021-pol2qm74 2754 14 IL-2 il-2 NN cord-015021-pol2qm74 2754 15 gene gene NN cord-015021-pol2qm74 2754 16 transcription transcription NN cord-015021-pol2qm74 2754 17 and and CC cord-015021-pol2qm74 2754 18 IL-2 IL-2 NNP cord-015021-pol2qm74 2754 19 protein protein NN cord-015021-pol2qm74 2754 20 production production NN cord-015021-pol2qm74 2754 21 . . . cord-015021-pol2qm74 2754 22 IL-10 IL-10 NNP cord-015021-pol2qm74 2754 23 also also RB cord-015021-pol2qm74 2754 24 inhibits inhibit VBZ cord-015021-pol2qm74 2754 25 the the DT cord-015021-pol2qm74 2754 26 production production NN cord-015021-pol2qm74 2754 27 of of IN cord-015021-pol2qm74 2754 28 the the DT cord-015021-pol2qm74 2754 29 pro pro JJ cord-015021-pol2qm74 2754 30 - - JJ cord-015021-pol2qm74 2754 31 inflammatory inflammatory JJ cord-015021-pol2qm74 2754 32 cytokines cytokine NNS cord-015021-pol2qm74 2754 33 IL IL NNP cord-015021-pol2qm74 2754 34 - - HYPH cord-015021-pol2qm74 2754 35 l l NN cord-015021-pol2qm74 2754 36 - - HYPH cord-015021-pol2qm74 2754 37 a a NN cord-015021-pol2qm74 2754 38 , , , cord-015021-pol2qm74 2754 39 ~ ~ NFP cord-015021-pol2qm74 2754 40 , , , cord-015021-pol2qm74 2754 41 IL-6 IL-6 NNP cord-015021-pol2qm74 2754 42 , , , cord-015021-pol2qm74 2754 43 and and CC cord-015021-pol2qm74 2754 44 TNF TNF NNP cord-015021-pol2qm74 2754 45 - - , cord-015021-pol2qm74 2754 46 a a NNP cord-015021-pol2qm74 2754 47 and and CC cord-015021-pol2qm74 2754 48 the the DT cord-015021-pol2qm74 2754 49 chemokines chemokine NNS cord-015021-pol2qm74 2754 50 IL-8 IL-8 NNP cord-015021-pol2qm74 2754 51 and and CC cord-015021-pol2qm74 2754 52 MIP MIP NNP cord-015021-pol2qm74 2754 53 - - HYPH cord-015021-pol2qm74 2754 54 I I NNP cord-015021-pol2qm74 2754 55 - - HYPH cord-015021-pol2qm74 2754 56 u u NNP cord-015021-pol2qm74 2754 57 , , , cord-015021-pol2qm74 2754 58 which which WDT cord-015021-pol2qm74 2754 59 are be VBP cord-015021-pol2qm74 2754 60 strong strong JJ cord-015021-pol2qm74 2754 61 chemo chemo NN cord-015021-pol2qm74 2754 62 attractants attractant NNS cord-015021-pol2qm74 2754 63 for for IN cord-015021-pol2qm74 2754 64 neutrophils neutrophil NNS cord-015021-pol2qm74 2754 65 and and CC cord-015021-pol2qm74 2754 66 macrophage macrophage NN cord-015021-pol2qm74 2754 67 , , , cord-015021-pol2qm74 2754 68 respectively respectively RB cord-015021-pol2qm74 2754 69 . . . cord-015021-pol2qm74 2755 1 In in IN cord-015021-pol2qm74 2755 2 contrast contrast NN cord-015021-pol2qm74 2755 3 , , , cord-015021-pol2qm74 2755 4 IL-10 IL-10 NNP cord-015021-pol2qm74 2755 5 enhances enhance VBZ cord-015021-pol2qm74 2755 6 the the DT cord-015021-pol2qm74 2755 7 production production NN cord-015021-pol2qm74 2755 8 of of IN cord-015021-pol2qm74 2755 9 the the DT cord-015021-pol2qm74 2755 10 IL-1 IL-1 NNP cord-015021-pol2qm74 2755 11 receptor receptor NN cord-015021-pol2qm74 2755 12 antagonist antagonist NN cord-015021-pol2qm74 2755 13 , , , cord-015021-pol2qm74 2755 14 a a DT cord-015021-pol2qm74 2755 15 cytokine cytokine NN cord-015021-pol2qm74 2755 16 with with IN cord-015021-pol2qm74 2755 17 anti anti JJ cord-015021-pol2qm74 2755 18 - - JJ cord-015021-pol2qm74 2755 19 inflammatory inflammatory JJ cord-015021-pol2qm74 2755 20 activity activity NN cord-015021-pol2qm74 2755 21 . . . cord-015021-pol2qm74 2756 1 IL IL NNP cord-015021-pol2qm74 2756 2 - - HYPH cord-015021-pol2qm74 2756 3 l0 l0 NNP cord-015021-pol2qm74 2756 4 produced produce VBN cord-015021-pol2qm74 2756 5 by by IN cord-015021-pol2qm74 2756 6 monocytes monocyte NNS cord-015021-pol2qm74 2756 7 downregulates downregulate VBZ cord-015021-pol2qm74 2756 8 class class NN cord-015021-pol2qm74 2756 9 II II NNP cord-015021-pol2qm74 2756 10 MHC MHC NNP cord-015021-pol2qm74 2756 11 expression expression NN cord-015021-pol2qm74 2756 12 and and CC cord-015021-pol2qm74 2756 13 IL-10 IL-10 NNP cord-015021-pol2qm74 2756 14 production production NN cord-015021-pol2qm74 2756 15 by by IN cord-015021-pol2qm74 2756 16 these these DT cord-015021-pol2qm74 2756 17 cells cell NNS cord-015021-pol2qm74 2756 18 in in IN cord-015021-pol2qm74 2756 19 an an DT cord-015021-pol2qm74 2756 20 autoregulatory autoregulatory JJ cord-015021-pol2qm74 2756 21 fashion fashion NN cord-015021-pol2qm74 2756 22 . . . cord-015021-pol2qm74 2757 1 Collectively collectively RB cord-015021-pol2qm74 2757 2 , , , cord-015021-pol2qm74 2757 3 these these DT cord-015021-pol2qm74 2757 4 in in IN cord-015021-pol2qm74 2757 5 vitro vitro FW cord-015021-pol2qm74 2757 6 data datum NNS cord-015021-pol2qm74 2757 7 indicate indicate VBP cord-015021-pol2qm74 2757 8 that that IN cord-015021-pol2qm74 2757 9 IL-10 IL-10 NNP cord-015021-pol2qm74 2757 10 is be VBZ cord-015021-pol2qm74 2757 11 a a DT cord-015021-pol2qm74 2757 12 powerful powerful JJ cord-015021-pol2qm74 2757 13 suppressor suppressor NN cord-015021-pol2qm74 2757 14 factor factor NN cord-015021-pol2qm74 2757 15 for for IN cord-015021-pol2qm74 2757 16 immune immune NN cord-015021-pol2qm74 2757 17 - - HYPH cord-015021-pol2qm74 2757 18 and and CC cord-015021-pol2qm74 2757 19 inflammatory inflammatory JJ cord-015021-pol2qm74 2757 20 responses response NNS cord-015021-pol2qm74 2757 21 and and CC cord-015021-pol2qm74 2757 22 therefore therefore RB cord-015021-pol2qm74 2757 23 may may MD cord-015021-pol2qm74 2757 24 have have VB cord-015021-pol2qm74 2757 25 potential potential JJ cord-015021-pol2qm74 2757 26 clinical clinical JJ cord-015021-pol2qm74 2757 27 utility utility NN cord-015021-pol2qm74 2757 28 as as IN cord-015021-pol2qm74 2757 29 an an DT cord-015021-pol2qm74 2757 30 anti anti JJ cord-015021-pol2qm74 2757 31 - - JJ cord-015021-pol2qm74 2757 32 inflammatory inflammatory JJ cord-015021-pol2qm74 2757 33 agent agent NN cord-015021-pol2qm74 2757 34 . . . cord-015021-pol2qm74 2758 1 This this DT cord-015021-pol2qm74 2758 2 notion notion NN cord-015021-pol2qm74 2758 3 is be VBZ cord-015021-pol2qm74 2758 4 supported support VBN cord-015021-pol2qm74 2758 5 by by IN cord-015021-pol2qm74 2758 6 recent recent JJ cord-015021-pol2qm74 2758 7 studies study NNS cord-015021-pol2qm74 2758 8 which which WDT cord-015021-pol2qm74 2758 9 indicated indicate VBD cord-015021-pol2qm74 2758 10 that that IN cord-015021-pol2qm74 2758 11 IL-10 IL-10 NNP cord-015021-pol2qm74 2758 12 also also RB cord-015021-pol2qm74 2758 13 prevents prevent VBZ cord-015021-pol2qm74 2758 14 lethal lethal JJ cord-015021-pol2qm74 2758 15 LPS lp NNS cord-015021-pol2qm74 2758 16 - - HYPH cord-015021-pol2qm74 2758 17 induced induce VBN cord-015021-pol2qm74 2758 18 toxic toxic JJ cord-015021-pol2qm74 2758 19 shock shock NN cord-015021-pol2qm74 2758 20 in in IN cord-015021-pol2qm74 2758 21 mice mouse NNS cord-015021-pol2qm74 2758 22 . . . cord-015021-pol2qm74 2759 1 Five five CD cord-015021-pol2qm74 2759 2 of of IN cord-015021-pol2qm74 2759 3 the the DT cord-015021-pol2qm74 2759 4 chamekines chamekine NNS cord-015021-pol2qm74 2759 5 ( ( -LRB- cord-015021-pol2qm74 2759 6 HIP HIP NNP cord-015021-pol2qm74 2759 7 - - HYPH cord-015021-pol2qm74 2759 8 I~,eRA I~,eRA NNP cord-015021-pol2qm74 2759 9 ~ ~ NFP cord-015021-pol2qm74 2759 10 TES TES NNP cord-015021-pol2qm74 2759 11 . . . cord-015021-pol2qm74 2760 1 IP IP NNP cord-015021-pol2qm74 2760 2 - - HYPH cord-015021-pol2qm74 2760 3 IO IO NNP cord-015021-pol2qm74 2760 4 and and CC cord-015021-pol2qm74 2760 5 IL IL NNP cord-015021-pol2qm74 2760 6 8) 8) NNP cord-015021-pol2qm74 2760 7 also also RB cord-015021-pol2qm74 2760 8 chemoattraet chemoattraet NNP cord-015021-pol2qm74 2760 9 T t NN cord-015021-pol2qm74 2760 10 lymphocytes lymphocyte NNS cord-015021-pol2qm74 2760 11 , , , cord-015021-pol2qm74 2760 12 while while IN cord-015021-pol2qm74 2760 13 others other NNS cord-015021-pol2qm74 2760 14 act act VBP cord-015021-pol2qm74 2760 15 on on IN cord-015021-pol2qm74 2760 16 mast mast NN cord-015021-pol2qm74 2760 17 cells cell NNS cord-015021-pol2qm74 2760 18 . . . cord-015021-pol2qm74 2761 1 We -PRON- PRP cord-015021-pol2qm74 2761 2 have have VBP cord-015021-pol2qm74 2761 3 studied study VBN cord-015021-pol2qm74 2761 4 the the DT cord-015021-pol2qm74 2761 5 effaces efface NNS cord-015021-pol2qm74 2761 6 of of IN cord-015021-pol2qm74 2761 7 these these DT cord-015021-pol2qm74 2761 8 chemokines chemokine NNS cord-015021-pol2qm74 2761 9 on on IN cord-015021-pol2qm74 2761 10 T T NNP cord-015021-pol2qm74 2761 11 cell cell NN cord-015021-pol2qm74 2761 12 subsets subset NNS cord-015021-pol2qm74 2761 13 . . . cord-015021-pol2qm74 2762 1 IL IL NNP cord-015021-pol2qm74 2762 2 8 8 CD cord-015021-pol2qm74 2762 3 preferentially preferentially RB cord-015021-pol2qm74 2762 4 chemoattracts chemoattract VBZ cord-015021-pol2qm74 2762 5 uns uns NNPS cord-015021-pol2qm74 2762 6 ~ ~ NFP cord-015021-pol2qm74 2762 7 imulated imulated JJ cord-015021-pol2qm74 2762 8 T T NNP cord-015021-pol2qm74 2762 9 Cells Cells NNPS cord-015021-pol2qm74 2762 10 . . . cord-015021-pol2qm74 2763 1 RAISES raise VBZ cord-015021-pol2qm74 2763 2 ~ttracte ~ttracte NFP cord-015021-pol2qm74 2763 3 resting rest VBG cord-015021-pol2qm74 2763 4 as as RB cord-015021-pol2qm74 2763 5 well well RB cord-015021-pol2qm74 2763 6 as as IN cord-015021-pol2qm74 2763 7 activated activate VBN cord-015021-pol2qm74 2763 8 CD4 CD4 NNP cord-015021-pol2qm74 2763 9 and and CC cord-015021-pol2qm74 2763 10 CD8 CD8 NNP cord-015021-pol2qm74 2763 11 memory memory NN cord-015021-pol2qm74 2763 12 T T NNP cord-015021-pol2qm74 2763 13 cells cell NNS cord-015021-pol2qm74 2763 14 . . . cord-015021-pol2qm74 2764 1 IP-10 IP-10 NNP cord-015021-pol2qm74 2764 2 chemoattracts chemoattract VBZ cord-015021-pol2qm74 2764 3 only only RB cord-015021-pol2qm74 2764 4 preactivated preactivate VBN cord-015021-pol2qm74 2764 5 ( ( -LRB- cord-015021-pol2qm74 2764 6 not not RB cord-015021-pol2qm74 2764 7 resting rest VBG cord-015021-pol2qm74 2764 8 ) ) -RRB- cord-015021-pol2qm74 2765 1 CD4 CD4 NNP cord-015021-pol2qm74 2765 2 or or CC cord-015021-pol2qm74 2765 3 CD8 CD8 NNP cord-015021-pol2qm74 2765 4 T T NNP cord-015021-pol2qm74 2765 5 cells cell NNS cord-015021-pol2qm74 2765 6 . . . cord-015021-pol2qm74 2766 1 HIP HIP NNP cord-015021-pol2qm74 2766 2 - - HYPH cord-015021-pol2qm74 2766 3 l~ l~ XX cord-015021-pol2qm74 2766 4 preferentially preferentially RB cord-015021-pol2qm74 2766 5 chemoattracts chemoattract VBZ cord-015021-pol2qm74 2766 6 GD8 GD8 NNP cord-015021-pol2qm74 2766 7 T T NNP cord-015021-pol2qm74 2766 8 calla calla NN cord-015021-pol2qm74 2766 9 , , , cord-015021-pol2qm74 2766 10 while while IN cord-015021-pol2qm74 2766 11 HIP-18 HIP-18 NNP cord-015021-pol2qm74 2766 12 more more RBR cord-015021-pol2qm74 2766 13 readily readily RB cord-015021-pol2qm74 2766 14 attracts attract VBZ cord-015021-pol2qm74 2766 15 the the DT cord-015021-pol2qm74 2766 16 CD4 CD4 NNP cord-015021-pol2qm74 2766 17 T T NNP cord-015021-pol2qm74 2766 18 call call NN cord-015021-pol2qm74 2766 19 subset subset JJ cord-015021-pol2qm74 2766 20 . . . cord-015021-pol2qm74 2767 1 The the DT cord-015021-pol2qm74 2767 2 8 8 CD cord-015021-pol2qm74 2767 3 chemoklnes chemoklne NNS cord-015021-pol2qm74 2767 4 and and CC cord-015021-pol2qm74 2767 5 IP IP NNP cord-015021-pol2qm74 2767 6 - - HYPH cord-015021-pol2qm74 2767 7 IO IO NNP cord-015021-pol2qm74 2767 8 were be VBD cord-015021-pol2qm74 2767 9 also also RB cord-015021-pol2qm74 2767 10 sho sho NNP cord-015021-pol2qm74 2767 11 ~ ~ NFP cord-015021-pol2qm74 2767 12 rn rn NN cord-015021-pol2qm74 2767 13 to to TO cord-015021-pol2qm74 2767 14 promote promote VB cord-015021-pol2qm74 2767 15 the the DT cord-015021-pol2qm74 2767 16 adherence adherence NN cord-015021-pol2qm74 2767 17 of of IN cord-015021-pol2qm74 2767 18 ~he ~he JJ cord-015021-pol2qm74 2767 19 same same JJ cord-015021-pol2qm74 2767 20 subsets subset NNS cord-015021-pol2qm74 2767 21 of of IN cord-015021-pol2qm74 2767 22 anti anti JJ cord-015021-pol2qm74 2767 23 - - NNP cord-015021-pol2qm74 2767 24 CD3 CD3 NNP cord-015021-pol2qm74 2767 25 activated activate VBN cord-015021-pol2qm74 2767 26 T T NNP cord-015021-pol2qm74 2767 27 cells cell NNS cord-015021-pol2qm74 2767 28 to to IN cord-015021-pol2qm74 2767 29 ILI ILI NNP cord-015021-pol2qm74 2767 30 activated activate VBD cord-015021-pol2qm74 2767 31 human human JJ cord-015021-pol2qm74 2767 32 umbilical umbilical JJ cord-015021-pol2qm74 2767 33 vein vein NN cord-015021-pol2qm74 2767 34 endothelial endothelial JJ cord-015021-pol2qm74 2767 35 cells cell NNS cord-015021-pol2qm74 2767 36 ( ( -LRB- cord-015021-pol2qm74 2767 37 HITVEC HITVEC NNP cord-015021-pol2qm74 2767 38 ) ) -RRB- cord-015021-pol2qm74 2767 39 . . . cord-015021-pol2qm74 2768 1 This this DT cord-015021-pol2qm74 2768 2 was be VBD cord-015021-pol2qm74 2768 3 not not RB cord-015021-pol2qm74 2768 4 associated associate VBN cord-015021-pol2qm74 2768 5 with with IN cord-015021-pol2qm74 2768 6 a a DT cord-015021-pol2qm74 2768 7 ~ ~ NNP cord-015021-pol2qm74 2768 8 y y NNP cord-015021-pol2qm74 2768 9 i~ i~ CD cord-015021-pol2qm74 2769 1 crease crease VB cord-015021-pol2qm74 2769 2 in in IN cord-015021-pol2qm74 2769 3 the the DT cord-015021-pol2qm74 2769 4 number number NN cord-015021-pol2qm74 2769 5 of of IN cord-015021-pol2qm74 2769 6 lymphocyte lymphocyte NN cord-015021-pol2qm74 2769 7 adhesion adhesion NN cord-015021-pol2qm74 2769 8 molecules molecule NNS cord-015021-pol2qm74 2769 9 , , , cord-015021-pol2qm74 2769 10 bu~ bu~ FW cord-015021-pol2qm74 2769 11 could could MD cord-015021-pol2qm74 2769 12 be be VB cord-015021-pol2qm74 2769 13 inhibited inhibit VBN cord-015021-pol2qm74 2769 14 by by IN cord-015021-pol2qm74 2769 15 neutralizing neutralize VBG cord-015021-pol2qm74 2769 16 monoclonal monoclonal JJ cord-015021-pol2qm74 2769 17 antibodies antibody NNS cord-015021-pol2qm74 2769 18 re re IN cord-015021-pol2qm74 2769 19 LFA LFA NNP cord-015021-pol2qm74 2769 20 - - HYPH cord-015021-pol2qm74 2769 21 I I NNP cord-015021-pol2qm74 2769 22 and and CC cord-015021-pol2qm74 2769 23 VLA-4 VLA-4 NNP cord-015021-pol2qm74 2769 24 . . . cord-015021-pol2qm74 2770 1 These these DT cord-015021-pol2qm74 2770 2 chemokines chemokine NNS cord-015021-pol2qm74 2770 3 also also RB cord-015021-pol2qm74 2770 4 rapidly rapidly RB cord-015021-pol2qm74 2770 5 increased increase VBD cord-015021-pol2qm74 2770 6 ~ha ~ha JJ cord-015021-pol2qm74 2770 7 adhesion adhesion NN cord-015021-pol2qm74 2770 8 of of IN cord-015021-pol2qm74 2770 9 resting rest VBG cord-015021-pol2qm74 2770 10 T T NNP cord-015021-pol2qm74 2770 11 l l NNP cord-015021-pol2qm74 2770 12 ~ ~ NFP cord-015021-pol2qm74 2770 13 phoeytes phoeyte NNS cord-015021-pol2qm74 2770 14 to to IN cord-015021-pol2qm74 2770 15 plates plate NNS cord-015021-pol2qm74 2770 16 coated coat VBD cord-015021-pol2qm74 2770 17 wi wi NNP cord-015021-pol2qm74 2771 1 ~h ~h NNP cord-015021-pol2qm74 2771 2 8 8 CD cord-015021-pol2qm74 2771 3 integrlns integrln NNS cord-015021-pol2qm74 2771 4 ( ( -LRB- cord-015021-pol2qm74 2771 5 I I NNP cord-015021-pol2qm74 2771 6 - - HYPH cord-015021-pol2qm74 2771 7 CAM CAM NNP cord-015021-pol2qm74 2771 8 or or CC cord-015021-pol2qm74 2771 9 V v NN cord-015021-pol2qm74 2771 10 - - HYPH cord-015021-pol2qm74 2771 11 CAM cam NN cord-015021-pol2qm74 2771 12 ) ) -RRB- cord-015021-pol2qm74 2771 13 or or CC cord-015021-pol2qm74 2771 14 matrix matrix NN cord-015021-pol2qm74 2771 15 proteins protein NNS cord-015021-pol2qm74 2771 16 such such JJ cord-015021-pol2qm74 2771 17 as as IN cord-015021-pol2qm74 2771 18 f f NNP cord-015021-pol2qm74 2771 19 ~ ~ NFP cord-015021-pol2qm74 2771 20 bronectln bronectln NNP cord-015021-pol2qm74 2771 21 . . . cord-015021-pol2qm74 2772 1 This this DT cord-015021-pol2qm74 2772 2 induction induction NN cord-015021-pol2qm74 2772 3 of of IN cord-015021-pol2qm74 2772 4 adhesion adhesion NN cord-015021-pol2qm74 2772 5 began begin VBD cord-015021-pol2qm74 2772 6 wiEhln wiEhln NNP cord-015021-pol2qm74 2772 7 30 30 CD cord-015021-pol2qm74 2772 8 ' ' '' cord-015021-pol2qm74 2772 9 , , , cord-015021-pol2qm74 2772 10 peaked peak VBD cord-015021-pol2qm74 2772 11 by by IN cord-015021-pol2qm74 2772 12 1 1 CD cord-015021-pol2qm74 2772 13 hr hr NN cord-015021-pol2qm74 2772 14 and and CC cord-015021-pol2qm74 2772 15 was be VBD cord-015021-pol2qm74 2772 16 completed complete VBN cord-015021-pol2qm74 2772 17 in in IN cord-015021-pol2qm74 2772 18 3 3 CD cord-015021-pol2qm74 2772 19 hr hr NN cord-015021-pol2qm74 2772 20 . . . cord-015021-pol2qm74 2773 1 This this DT cord-015021-pol2qm74 2773 2 suggests suggest VBZ cord-015021-pol2qm74 2773 3 that that IN cord-015021-pol2qm74 2773 4 chemoklnee chemoklnee FW cord-015021-pol2qm74 2773 5 rapldly rapldly RB cord-015021-pol2qm74 2773 6 increase increase VBP cord-015021-pol2qm74 2773 7 the the DT cord-015021-pol2qm74 2773 8 binding bind VBG cord-015021-pol2qm74 2773 9 affinity affinity NN cord-015021-pol2qm74 2773 10 of of IN cord-015021-pol2qm74 2773 11 adhesion adhesion NN cord-015021-pol2qm74 2773 12 prote prote NNP cord-015021-pol2qm74 2773 13 ~ ~ NFP cord-015021-pol2qm74 2773 14 ns ns XX cord-015021-pol2qm74 2773 15 on on IN cord-015021-pol2qm74 2773 16 T t NN cord-015021-pol2qm74 2773 17 cells cell NNS cord-015021-pol2qm74 2773 18 . . . cord-015021-pol2qm74 2774 1 We -PRON- PRP cord-015021-pol2qm74 2774 2 also also RB cord-015021-pol2qm74 2774 3 recently recently RB cord-015021-pol2qm74 2774 4 observed observe VBD cord-015021-pol2qm74 2774 5 ~hat ~hat XX cord-015021-pol2qm74 2775 1 MCAF MCAF NNP cord-015021-pol2qm74 2775 2 / / SYM cord-015021-pol2qm74 2775 3 MCPI MCPI NNP cord-015021-pol2qm74 2775 4 and and CC cord-015021-pol2qm74 2775 5 RANTES RANTES NNP cord-015021-pol2qm74 2775 6 chemoattract chemoattract NNP cord-015021-pol2qm74 2775 7 unatimulated unatimulate VBN cord-015021-pol2qm74 2775 8 mast mast NN cord-015021-pol2qm74 2775 9 calls call NNS cord-015021-pol2qm74 2775 10 . . . cord-015021-pol2qm74 2776 1 Furthermore furthermore RB cord-015021-pol2qm74 2776 2 , , , cord-015021-pol2qm74 2776 3 IgS IgS NNP cord-015021-pol2qm74 2776 4 actlvared actlvared JJ cord-015021-pol2qm74 2776 5 mast mast NN cord-015021-pol2qm74 2776 6 calls call NNS cord-015021-pol2qm74 2776 7 were be VBD cord-015021-pol2qm74 2776 8 chemoattraeted chemoattraete VBN cord-015021-pol2qm74 2776 9 by by IN cord-015021-pol2qm74 2776 10 MCAF MCAF NNP cord-015021-pol2qm74 2776 11 , , , cord-015021-pol2qm74 2776 12 RA RA NNP cord-015021-pol2qm74 2776 13 ~ ~ NNP cord-015021-pol2qm74 2776 14 TES TES NNP cord-015021-pol2qm74 2776 15 , , , cord-015021-pol2qm74 2776 16 PF4 pf4 NN cord-015021-pol2qm74 2776 17 and and CC cord-015021-pol2qm74 2776 18 MIP.I~. mip.i~. NN cord-015021-pol2qm74 2776 19 However however RB cord-015021-pol2qm74 2776 20 . . . cord-015021-pol2qm74 2777 1 ~he ~he NNP cord-015021-pol2qm74 2777 2 chemoklnee chemoklnee NNP cord-015021-pol2qm74 2777 3 did do VBD cord-015021-pol2qm74 2777 4 not not RB cord-015021-pol2qm74 2777 5 induce induce VB cord-015021-pol2qm74 2777 6 mast mast NN cord-015021-pol2qm74 2777 7 cells cell NNS cord-015021-pol2qm74 2777 8 ~o ~o NNP cord-015021-pol2qm74 2777 9 release release NN cord-015021-pol2qm74 2777 10 histamines histamine NNS cord-015021-pol2qm74 2777 11 . . . cord-015021-pol2qm74 2778 1 Presumably presumably RB cord-015021-pol2qm74 2778 2 , , , cord-015021-pol2qm74 2778 3 chemokines chemokine NNS cord-015021-pol2qm74 2778 4 as as IN cord-015021-pol2qm74 2778 5 regulators regulator NNS cord-015021-pol2qm74 2778 6 of of IN cord-015021-pol2qm74 2778 7 the the DT cord-015021-pol2qm74 2778 8 adhesion adhesion NN cord-015021-pol2qm74 2778 9 , , , cord-015021-pol2qm74 2778 10 migration migration NN cord-015021-pol2qm74 2778 11 and and CC cord-015021-pol2qm74 2778 12 homing homing NN cord-015021-pol2qm74 2778 13 of of IN cord-015021-pol2qm74 2778 14 all all DT cord-015021-pol2qm74 2778 15 kinds kind NNS cord-015021-pol2qm74 2778 16 of of IN cord-015021-pol2qm74 2778 17 leukocytes leukocyte NNS cord-015021-pol2qm74 2778 18 participate participate VBP cord-015021-pol2qm74 2778 19 in in IN cord-015021-pol2qm74 2778 20 many many JJ cord-015021-pol2qm74 2778 21 types type NNS cord-015021-pol2qm74 2778 22 of of IN cord-015021-pol2qm74 2778 23 inflammatory inflammatory JJ cord-015021-pol2qm74 2778 24 diseases disease NNS cord-015021-pol2qm74 2778 25 . . . cord-015021-pol2qm74 2779 1 Natural natural JJ cord-015021-pol2qm74 2779 2 killer killer NN cord-015021-pol2qm74 2779 3 cell cell NN cord-015021-pol2qm74 2779 4 stimulatory stimulatory JJ cord-015021-pol2qm74 2779 5 factor factor NN cord-015021-pol2qm74 2779 6 or or CC cord-015021-pol2qm74 2779 7 interleukin-12 interleukin-12 XX cord-015021-pol2qm74 2779 8 ( ( -LRB- cord-015021-pol2qm74 2779 9 IL-12 IL-12 NNP cord-015021-pol2qm74 2779 10 ) ) -RRB- cord-015021-pol2qm74 2779 11 is be VBZ cord-015021-pol2qm74 2779 12 an an DT cord-015021-pol2qm74 2779 13 heterodimerie heterodimerie NNP cord-015021-pol2qm74 2779 14 cytokine cytokine NN cord-015021-pol2qm74 2779 15 formed form VBN cord-015021-pol2qm74 2779 16 by by IN cord-015021-pol2qm74 2779 17 two two CD cord-015021-pol2qm74 2779 18 covalently covalently RB cord-015021-pol2qm74 2779 19 linked link VBN cord-015021-pol2qm74 2779 20 glycosylated glycosylated JJ cord-015021-pol2qm74 2779 21 chains chain NNS cord-015021-pol2qm74 2779 22 of of IN cord-015021-pol2qm74 2779 23 35kD 35kd CD cord-015021-pol2qm74 2779 24 and and CC cord-015021-pol2qm74 2779 25 40 40 CD cord-015021-pol2qm74 2779 26 kD. kd. NN cord-015021-pol2qm74 2779 27 IL-12 IL-12 NNP cord-015021-pol2qm74 2779 28 was be VBD cord-015021-pol2qm74 2779 29 originally originally RB cord-015021-pol2qm74 2779 30 purified purify VBN cord-015021-pol2qm74 2779 31 from from IN cord-015021-pol2qm74 2779 32 the the DT cord-015021-pol2qm74 2779 33 supermatant supermatant JJ cord-015021-pol2qm74 2779 34 fluids fluid NNS cord-015021-pol2qm74 2779 35 of of IN cord-015021-pol2qm74 2779 36 EBV EBV NNP cord-015021-pol2qm74 2779 37 - - HYPH cord-015021-pol2qm74 2779 38 transformed transform VBN cord-015021-pol2qm74 2779 39 human human NN cord-015021-pol2qm74 2779 40 B b NN cord-015021-pol2qm74 2779 41 ly ly NNP cord-015021-pol2qm74 2779 42 ~ ~ NFP cord-015021-pol2qm74 2779 43 phobiastoid phobiastoid NNP cord-015021-pol2qm74 2779 44 cell cell NN cord-015021-pol2qm74 2779 45 lines line NNS cord-015021-pol2qm74 2779 46 . . . cord-015021-pol2qm74 2780 1 However however RB cord-015021-pol2qm74 2780 2 , , , cord-015021-pol2qm74 2780 3 in in IN cord-015021-pol2qm74 2780 4 addition addition NN cord-015021-pol2qm74 2780 5 to to IN cord-015021-pol2qm74 2780 6 B b NN cord-015021-pol2qm74 2780 7 cells cell NNS cord-015021-pol2qm74 2780 8 , , , cord-015021-pol2qm74 2780 9 phagocytic phagocytic JJ cord-015021-pol2qm74 2780 10 cells cell NNS cord-015021-pol2qm74 2780 11 , , , cord-015021-pol2qm74 2780 12 i.e. i.e. FW cord-015021-pol2qm74 2780 13 monocytes monocyte NNS cord-015021-pol2qm74 2780 14 , , , cord-015021-pol2qm74 2780 15 macrophages macrophage NNS cord-015021-pol2qm74 2780 16 , , , cord-015021-pol2qm74 2780 17 and and CC cord-015021-pol2qm74 2780 18 neutrophils neutrophil NNS cord-015021-pol2qm74 2780 19 , , , cord-015021-pol2qm74 2780 20 have have VBP cord-015021-pol2qm74 2780 21 been be VBN cord-015021-pol2qm74 2780 22 identified identify VBN cord-015021-pol2qm74 2780 23 as as IN cord-015021-pol2qm74 2780 24 the the DT cord-015021-pol2qm74 2780 25 major major JJ cord-015021-pol2qm74 2780 26 physiological physiological JJ cord-015021-pol2qm74 2780 27 producers producer NNS cord-015021-pol2qm74 2780 28 of of IN cord-015021-pol2qm74 2780 29 IL-12 IL-12 NNP cord-015021-pol2qm74 2780 30 . . . cord-015021-pol2qm74 2781 1 Phagocytic phagocytic JJ cord-015021-pol2qm74 2781 2 cells cell NNS cord-015021-pol2qm74 2781 3 produce produce VBP cord-015021-pol2qm74 2781 4 IL-12 IL-12 NNP cord-015021-pol2qm74 2781 5 in in IN cord-015021-pol2qm74 2781 6 response response NN cord-015021-pol2qm74 2781 7 to to IN cord-015021-pol2qm74 2781 8 bacteria bacteria NNS cord-015021-pol2qm74 2781 9 , , , cord-015021-pol2qm74 2781 10 bacterial bacterial JJ cord-015021-pol2qm74 2781 11 products product NNS cord-015021-pol2qm74 2781 12 such such JJ cord-015021-pol2qm74 2781 13 as as IN cord-015021-pol2qm74 2781 14 LPS LPS NNP cord-015021-pol2qm74 2781 15 , , , cord-015021-pol2qm74 2781 16 and and CC cord-015021-pol2qm74 2781 17 intracellular intracellular JJ cord-015021-pol2qm74 2781 18 parasites parasite NNS cord-015021-pol2qm74 2781 19 . . . cord-015021-pol2qm74 2782 1 The the DT cord-015021-pol2qm74 2782 2 cell cell NN cord-015021-pol2qm74 2782 3 types type NNS cord-015021-pol2qm74 2782 4 on on IN cord-015021-pol2qm74 2782 5 which which WDT cord-015021-pol2qm74 2782 6 IL-12 IL-12 NNP cord-015021-pol2qm74 2782 7 exert exert VB cord-015021-pol2qm74 2782 8 biological biological JJ cord-015021-pol2qm74 2782 9 activity activity NN cord-015021-pol2qm74 2782 10 are be VBP cord-015021-pol2qm74 2782 11 T T NNP cord-015021-pol2qm74 2782 12 and and CC cord-015021-pol2qm74 2782 13 NK NK NNP cord-015021-pol2qm74 2782 14 cells cell NNS cord-015021-pol2qm74 2782 15 . . . cord-015021-pol2qm74 2783 1 The the DT cord-015021-pol2qm74 2783 2 major major JJ cord-015021-pol2qm74 2783 3 direct direct JJ cord-015021-pol2qm74 2783 4 biological biological JJ cord-015021-pol2qm74 2783 5 function function NN cord-015021-pol2qm74 2783 6 of of IN cord-015021-pol2qm74 2783 7 IL-12 IL-12 NNP cord-015021-pol2qm74 2783 8 on on IN cord-015021-pol2qm74 2783 9 these these DT cord-015021-pol2qm74 2783 10 cell cell NN cord-015021-pol2qm74 2783 11 types type NNS cord-015021-pol2qm74 2783 12 are be VBP cord-015021-pol2qm74 2783 13 the the DT cord-015021-pol2qm74 2783 14 induction induction NN cord-015021-pol2qm74 2783 15 of of IN cord-015021-pol2qm74 2783 16 cytokine cytokine NN cord-015021-pol2qm74 2783 17 production production NN cord-015021-pol2qm74 2783 18 , , , cord-015021-pol2qm74 2783 19 primarily primarily RB cord-015021-pol2qm74 2783 20 IFN IFN NNP cord-015021-pol2qm74 2783 21 - - HYPH cord-015021-pol2qm74 2783 22 y y NNP cord-015021-pol2qm74 2783 23 , , , cord-015021-pol2qm74 2783 24 the the DT cord-015021-pol2qm74 2783 25 enhancement enhancement NN cord-015021-pol2qm74 2783 26 of of IN cord-015021-pol2qm74 2783 27 a a DT cord-015021-pol2qm74 2783 28 generation generation NN cord-015021-pol2qm74 2783 29 of of IN cord-015021-pol2qm74 2783 30 cytotoxic cytotoxic JJ cord-015021-pol2qm74 2783 31 cells cell NNS cord-015021-pol2qm74 2783 32 , , , cord-015021-pol2qm74 2783 33 and and CC cord-015021-pol2qm74 2783 34 a a DT cord-015021-pol2qm74 2783 35 mitogenic mitogenic JJ cord-015021-pol2qm74 2783 36 effect effect NN cord-015021-pol2qm74 2783 37 on on IN cord-015021-pol2qm74 2783 38 antlgen antlgen NN cord-015021-pol2qm74 2783 39 - - HYPH cord-015021-pol2qm74 2783 40 activated activate VBN cord-015021-pol2qm74 2783 41 lymphocytes lymphocyte NNS cord-015021-pol2qm74 2783 42 . . . cord-015021-pol2qm74 2784 1 In in IN cord-015021-pol2qm74 2784 2 part part NN cord-015021-pol2qm74 2784 3 thromgh thromgh VBZ cord-015021-pol2qm74 2784 4 its -PRON- PRP$ cord-015021-pol2qm74 2784 5 ability ability NN cord-015021-pol2qm74 2784 6 to to TO cord-015021-pol2qm74 2784 7 induce induce VB cord-015021-pol2qm74 2784 8 IFN IFN NNP cord-015021-pol2qm74 2784 9 - - HYPH cord-015021-pol2qm74 2784 10 y y NNP cord-015021-pol2qm74 2784 11 production production NN cord-015021-pol2qm74 2784 12 , , , cord-015021-pol2qm74 2785 1 IL-12 IL-12 NNP cord-015021-pol2qm74 2785 2 , , , cord-015021-pol2qm74 2785 3 produced produce VBN cord-015021-pol2qm74 2785 4 in in IN cord-015021-pol2qm74 2785 5 response response NN cord-015021-pol2qm74 2785 6 to to IN cord-015021-pol2qm74 2785 7 infections infection NNS cord-015021-pol2qm74 2785 8 , , , cord-015021-pol2qm74 2785 9 represents represent VBZ cord-015021-pol2qm74 2785 10 an an DT cord-015021-pol2qm74 2785 11 important important JJ cord-015021-pol2qm74 2785 12 functional functional JJ cord-015021-pol2qm74 2785 13 link link NN cord-015021-pol2qm74 2785 14 between between IN cord-015021-pol2qm74 2785 15 effector effector NN cord-015021-pol2qm74 2785 16 cells cell NNS cord-015021-pol2qm74 2785 17 of of IN cord-015021-pol2qm74 2785 18 innate innate JJ cord-015021-pol2qm74 2785 19 resistance resistance NN cord-015021-pol2qm74 2785 20 , , , cord-015021-pol2qm74 2785 21 phagocytic phagocytic JJ cord-015021-pol2qm74 2785 22 cells cell NNS cord-015021-pol2qm74 2785 23 and and CC cord-015021-pol2qm74 2785 24 NK NK NNP cord-015021-pol2qm74 2785 25 cells cell NNS cord-015021-pol2qm74 2785 26 , , , cord-015021-pol2qm74 2785 27 and and CC cord-015021-pol2qm74 2785 28 effector effector NN cord-015021-pol2qm74 2785 29 cells cell NNS cord-015021-pol2qm74 2785 30 of of IN cord-015021-pol2qm74 2785 31 adaptiye adaptiye JJ cord-015021-pol2qm74 2785 32 resistance resistance NN cord-015021-pol2qm74 2785 33 , , , cord-015021-pol2qm74 2785 34 T T NNP cord-015021-pol2qm74 2785 35 and and CC cord-015021-pol2qm74 2785 36 B b NN cord-015021-pol2qm74 2785 37 lymphocytes lymphocyte NNS cord-015021-pol2qm74 2785 38 . . . cord-015021-pol2qm74 2786 1 The the DT cord-015021-pol2qm74 2786 2 ability ability NN cord-015021-pol2qm74 2786 3 of of IN cord-015021-pol2qm74 2786 4 IL-12 IL-12 NNP cord-015021-pol2qm74 2786 5 to to TO cord-015021-pol2qm74 2786 6 induce induce VB cord-015021-pol2qm74 2786 7 IFN IFN NNP cord-015021-pol2qm74 2786 8 - - HYPH cord-015021-pol2qm74 2786 9 y y NNP cord-015021-pol2qm74 2786 10 production production NN cord-015021-pol2qm74 2786 11 from from IN cord-015021-pol2qm74 2786 12 circulating circulate VBG cord-015021-pol2qm74 2786 13 . . . cord-015021-pol2qm74 2787 1 NK NK NNP cord-015021-pol2qm74 2787 2 cells cell NNS cord-015021-pol2qm74 2787 3 and and CC cord-015021-pol2qm74 2787 4 at at IN cord-015021-pol2qm74 2787 5 least least JJS cord-015021-pol2qm74 2787 6 a a DT cord-015021-pol2qm74 2787 7 proportion proportion NN cord-015021-pol2qm74 2787 8 of of IN cord-015021-pol2qm74 2787 9 T t NN cord-015021-pol2qm74 2787 10 cells cell NNS cord-015021-pol2qm74 2787 11 determines determine VBZ cord-015021-pol2qm74 2787 12 a a DT cord-015021-pol2qm74 2787 13 rapid rapid JJ cord-015021-pol2qm74 2787 14 , , , cord-015021-pol2qm74 2787 15 antigen antigen NN cord-015021-pol2qm74 2787 16 - - HYPH cord-015021-pol2qm74 2787 17 independet independet JJ cord-015021-pol2qm74 2787 18 production production NN cord-015021-pol2qm74 2787 19 of of IN cord-015021-pol2qm74 2787 20 IFN IFN NNP cord-015021-pol2qm74 2787 21 - - HYPH cord-015021-pol2qm74 2787 22 y y NNP cord-015021-pol2qm74 2787 23 during during IN cord-015021-pol2qm74 2787 24 infections infection NNS cord-015021-pol2qm74 2787 25 . . . cord-015021-pol2qm74 2788 1 IFN IFN NNP cord-015021-pol2qm74 2788 2 - - HYPH cord-015021-pol2qm74 2788 3 y y NNP cord-015021-pol2qm74 2788 4 acts act VBZ cord-015021-pol2qm74 2788 5 as as IN cord-015021-pol2qm74 2788 6 a a DT cord-015021-pol2qm74 2788 7 potent potent JJ cord-015021-pol2qm74 2788 8 enhancer enhancer NN cord-015021-pol2qm74 2788 9 of of IN cord-015021-pol2qm74 2788 10 phagocytic phagocytic NN cord-015021-pol2qm74 2788 11 and and CC cord-015021-pol2qm74 2788 12 bacteriocidal bacteriocidal JJ cord-015021-pol2qm74 2788 13 activity activity NN cord-015021-pol2qm74 2788 14 of of IN cord-015021-pol2qm74 2788 15 phagocytic phagocytic JJ cord-015021-pol2qm74 2788 16 cells cell NNS cord-015021-pol2qm74 2788 17 , , , cord-015021-pol2qm74 2788 18 participating participate VBG cord-015021-pol2qm74 2788 19 early early RB cord-015021-pol2qm74 2788 20 in in IN cord-015021-pol2qm74 2788 21 infection infection NN cord-015021-pol2qm74 2788 22 to to TO cord-015021-pol2qm74 2788 23 activate activate VB cord-015021-pol2qm74 2788 24 some some DT cord-015021-pol2qm74 2788 25 of of IN cord-015021-pol2qm74 2788 26 the the DT cord-015021-pol2qm74 2788 27 inflammatory inflammatory JJ cord-015021-pol2qm74 2788 28 mechanisms mechanism NNS cord-015021-pol2qm74 2788 29 that that WDT cord-015021-pol2qm74 2788 30 represent represent VBP cord-015021-pol2qm74 2788 31 the the DT cord-015021-pol2qm74 2788 32 first first JJ cord-015021-pol2qm74 2788 33 innate innate JJ cord-015021-pol2qm74 2788 34 resistance resistance NN cord-015021-pol2qm74 2788 35 against against IN cord-015021-pol2qm74 2788 36 infection infection NN cord-015021-pol2qm74 2788 37 . . . cord-015021-pol2qm74 2789 1 This this DT cord-015021-pol2qm74 2789 2 antigem antigem NNS cord-015021-pol2qm74 2789 3 - - HYPH cord-015021-pol2qm74 2789 4 independet independet JJ cord-015021-pol2qm74 2789 5 activation activation NN cord-015021-pol2qm74 2789 6 of of IN cord-015021-pol2qm74 2789 7 phagocytic phagocytic JJ cord-015021-pol2qm74 2789 8 cells cell NNS cord-015021-pol2qm74 2789 9 that that WDT cord-015021-pol2qm74 2789 10 involves involve VBZ cord-015021-pol2qm74 2789 11 , , , cord-015021-pol2qm74 2789 12 in in IN cord-015021-pol2qm74 2789 13 addition addition NN cord-015021-pol2qm74 2789 14 to to IN cord-015021-pol2qm74 2789 15 IL-12 IL-12 NNP cord-015021-pol2qm74 2789 16 , , , cord-015021-pol2qm74 2789 17 other other JJ cord-015021-pol2qm74 2789 18 monocyte monocyte NNP cord-015021-pol2qm74 2789 19 derived derive VBD cord-015021-pol2qm74 2789 20 cytokines cytokine NNS cord-015021-pol2qm74 2789 21 such such JJ cord-015021-pol2qm74 2789 22 as as IN cord-015021-pol2qm74 2789 23 TNF TNF NNP cord-015021-pol2qm74 2789 24 and and CC cord-015021-pol2qm74 2789 25 IL IL NNP cord-015021-pol2qm74 2789 26 - - HYPH cord-015021-pol2qm74 2789 27 l l NNP cord-015021-pol2qm74 2789 28 , , , cord-015021-pol2qm74 2789 29 has have VBZ cord-015021-pol2qm74 2789 30 been be VBN cord-015021-pol2qm74 2789 31 shown show VBN cord-015021-pol2qm74 2789 32 to to TO cord-015021-pol2qm74 2789 33 be be VB cord-015021-pol2qm74 2789 34 important important JJ cord-015021-pol2qm74 2789 35 in in IN cord-015021-pol2qm74 2789 36 experimental experimental JJ cord-015021-pol2qm74 2789 37 animals animal NNS cord-015021-pol2qm74 2789 38 for for IN cord-015021-pol2qm74 2789 39 the the DT cord-015021-pol2qm74 2789 40 resistance resistance NN cord-015021-pol2qm74 2789 41 against against IN cord-015021-pol2qm74 2789 42 infection infection NN cord-015021-pol2qm74 2789 43 by by IN cord-015021-pol2qm74 2789 44 microorganisms microorganism NNS cord-015021-pol2qm74 2789 45 such such JJ cord-015021-pol2qm74 2789 46 as as IN cord-015021-pol2qm74 2789 47 Limteria Limteria NNP cord-015021-pol2qm74 2789 48 monocytogens monocytogens NN cord-015021-pol2qm74 2789 49 and and CC cord-015021-pol2qm74 2789 50 Toxoplasma toxoplasma NN cord-015021-pol2qm74 2789 51 gondii gondii NN cord-015021-pol2qm74 2789 52 . . . cord-015021-pol2qm74 2790 1 In in IN cord-015021-pol2qm74 2790 2 addition addition NN cord-015021-pol2qm74 2790 3 to to IN cord-015021-pol2qm74 2790 4 this this DT cord-015021-pol2qm74 2790 5 role role NN cord-015021-pol2qm74 2790 6 , , , cord-015021-pol2qm74 2790 7 early early RB cord-015021-pol2qm74 2790 8 in in IN cord-015021-pol2qm74 2790 9 infection infection NN cord-015021-pol2qm74 2790 10 in in IN cord-015021-pol2qm74 2790 11 the the DT cord-015021-pol2qm74 2790 12 antigen antigen NN cord-015021-pol2qm74 2790 13 - - HYPH cord-015021-pol2qm74 2790 14 independet independet JJ cord-015021-pol2qm74 2790 15 phagocytic phagocytic JJ cord-015021-pol2qm74 2790 16 cell cell NN cord-015021-pol2qm74 2790 17 activation activation NN cord-015021-pol2qm74 2790 18 , , , cord-015021-pol2qm74 2790 19 IL-12 IL-12 NNP cord-015021-pol2qm74 2790 20 has have VBZ cord-015021-pol2qm74 2790 21 a a DT cord-015021-pol2qm74 2790 22 major major JJ cord-015021-pol2qm74 2790 23 effect effect NN cord-015021-pol2qm74 2790 24 in in IN cord-015021-pol2qm74 2790 25 the the DT cord-015021-pol2qm74 2790 26 ensuing ensue VBG cord-015021-pol2qm74 2790 27 antigenspecific antigenspecific NNP cord-015021-pol2qm74 2790 28 admptive admptive NNP cord-015021-pol2qm74 2790 29 immune immune JJ cord-015021-pol2qm74 2790 30 response response NN cord-015021-pol2qm74 2790 31 by by IN cord-015021-pol2qm74 2790 32 facilitating facilitate VBG cord-015021-pol2qm74 2790 33 the the DT cord-015021-pol2qm74 2790 34 generation generation NN cord-015021-pol2qm74 2790 35 of of IN cord-015021-pol2qm74 2790 36 T T NNP cord-015021-pol2qm74 2790 37 helper helper NN cord-015021-pol2qm74 2790 38 type type NN cord-015021-pol2qm74 2790 39 1 1 CD cord-015021-pol2qm74 2790 40 ( ( -LRB- cord-015021-pol2qm74 2790 41 TH TH NNP cord-015021-pol2qm74 2790 42 - - HYPH cord-015021-pol2qm74 2790 43 I i NN cord-015021-pol2qm74 2790 44 ) ) -RRB- cord-015021-pol2qm74 2790 45 response response NN cord-015021-pol2qm74 2790 46 and and CC cord-015021-pol2qm74 2790 47 suppressing suppress VBG cord-015021-pol2qm74 2790 48 a a DT cord-015021-pol2qm74 2790 49 Th-2 Th-2 NNP cord-015021-pol2qm74 2790 50 response response NN cord-015021-pol2qm74 2790 51 . . . cord-015021-pol2qm74 2791 1 The the DT cord-015021-pol2qm74 2791 2 presence presence NN cord-015021-pol2qm74 2791 3 of of IN cord-015021-pol2qm74 2791 4 IL-12 IL-12 NNP cord-015021-pol2qm74 2791 5 during during IN cord-015021-pol2qm74 2791 6 antigen antigen NN cord-015021-pol2qm74 2791 7 stimulation stimulation NN cord-015021-pol2qm74 2791 8 in in IN cord-015021-pol2qm74 2791 9 vitro vitro FW cord-015021-pol2qm74 2791 10 using use VBG cord-015021-pol2qm74 2791 11 human human JJ cord-015021-pol2qm74 2791 12 peripheral peripheral JJ cord-015021-pol2qm74 2791 13 blood blood NN cord-015021-pol2qm74 2791 14 lymphocytes lymphocyte NNS cord-015021-pol2qm74 2791 15 , , , cord-015021-pol2qm74 2791 16 or or CC cord-015021-pol2qm74 2791 17 both both CC cord-015021-pol2qm74 2791 18 in in IN cord-015021-pol2qm74 2791 19 vivo vivo NN cord-015021-pol2qm74 2791 20 and and CC cord-015021-pol2qm74 2791 21 in in IN cord-015021-pol2qm74 2791 22 vitro vitro FW cord-015021-pol2qm74 2791 23 in in IN cord-015021-pol2qm74 2791 24 experimental experimental JJ cord-015021-pol2qm74 2791 25 animals animal NNS cord-015021-pol2qm74 2791 26 , , , cord-015021-pol2qm74 2791 27 induces induce VBZ cord-015021-pol2qm74 2791 28 generation generation NN cord-015021-pol2qm74 2791 29 of of IN cord-015021-pol2qm74 2791 30 Th Th NNP cord-015021-pol2qm74 2791 31 - - HYPH cord-015021-pol2qm74 2791 32 i i PRP cord-015021-pol2qm74 2791 33 cells cell NNS cord-015021-pol2qm74 2791 34 producing produce VBG cord-015021-pol2qm74 2791 35 IFN IFN NNP cord-015021-pol2qm74 2791 36 - - HYPH cord-015021-pol2qm74 2791 37 y y NNP cord-015021-pol2qm74 2791 38 and and CC cord-015021-pol2qm74 2791 39 IL-2 IL-2 NNP cord-015021-pol2qm74 2791 40 , , , cord-015021-pol2qm74 2791 41 and and CC cord-015021-pol2qm74 2791 42 inhibits inhibit VBZ cord-015021-pol2qm74 2791 43 the the DT cord-015021-pol2qm74 2791 44 generation generation NN cord-015021-pol2qm74 2791 45 of of IN cord-015021-pol2qm74 2791 46 Th-2 Th-2 NNP cord-015021-pol2qm74 2791 47 cells cell NNS cord-015021-pol2qm74 2791 48 producing produce VBG cord-015021-pol2qm74 2791 49 IL-4 IL-4 NNP cord-015021-pol2qm74 2791 50 . . . cord-015021-pol2qm74 2791 51 IL-12 IL-12 NNP cord-015021-pol2qm74 2791 52 induces induce VBZ cord-015021-pol2qm74 2791 53 a a DT cord-015021-pol2qm74 2791 54 direct direct JJ cord-015021-pol2qm74 2791 55 differentiative differentiative JJ cord-015021-pol2qm74 2791 56 effect effect NN cord-015021-pol2qm74 2791 57 on on IN cord-015021-pol2qm74 2791 58 Th Th NNP cord-015021-pol2qm74 2791 59 - - HYPH cord-015021-pol2qm74 2791 60 cells cell NNS cord-015021-pol2qm74 2791 61 , , , cord-015021-pol2qm74 2791 62 priming prime VBG cord-015021-pol2qm74 2791 63 them -PRON- PRP cord-015021-pol2qm74 2791 64 for for IN cord-015021-pol2qm74 2791 65 high high JJ cord-015021-pol2qm74 2791 66 IFN IFN NNP cord-015021-pol2qm74 2791 67 - - HYPH cord-015021-pol2qm74 2791 68 y y NNP cord-015021-pol2qm74 2791 69 production production NN cord-015021-pol2qm74 2791 70 . . . cord-015021-pol2qm74 2792 1 ~is ~is NFP cord-015021-pol2qm74 2792 2 priming prime VBG cord-015021-pol2qm74 2792 3 effect effect NN cord-015021-pol2qm74 2792 4 is be VBZ cord-015021-pol2qm74 2792 5 stable stable JJ cord-015021-pol2qm74 2792 6 and and CC cord-015021-pol2qm74 2792 7 maintained maintain VBD cord-015021-pol2qm74 2792 8 even even RB cord-015021-pol2qm74 2792 9 when when WRB cord-015021-pol2qm74 2792 10 T T NNP cord-015021-pol2qm74 2792 11 cell cell NN cord-015021-pol2qm74 2792 12 clones clone NNS cord-015021-pol2qm74 2792 13 are be VBP cord-015021-pol2qm74 2792 14 cultured culture VBN cord-015021-pol2qm74 2792 15 for for IN cord-015021-pol2qm74 2792 16 extended extended JJ cord-015021-pol2qm74 2792 17 periods period NNS cord-015021-pol2qm74 2792 18 in in IN cord-015021-pol2qm74 2792 19 the the DT cord-015021-pol2qm74 2792 20 absence absence NN cord-015021-pol2qm74 2792 21 of of IN cord-015021-pol2qm74 2792 22 IL-12 IL-12 NNP cord-015021-pol2qm74 2792 23 , , , cord-015021-pol2qm74 2792 24 however however RB cord-015021-pol2qm74 2792 25 , , , cord-015021-pol2qm74 2792 26 IL-12 IL-12 NNP cord-015021-pol2qm74 2792 27 needs need VBZ cord-015021-pol2qm74 2792 28 to to TO cord-015021-pol2qm74 2792 29 be be VB cord-015021-pol2qm74 2792 30 present present JJ cord-015021-pol2qm74 2792 31 during during IN cord-015021-pol2qm74 2792 32 the the DT cord-015021-pol2qm74 2792 33 first first JJ cord-015021-pol2qm74 2792 34 few few JJ cord-015021-pol2qm74 2792 35 days day NNS cord-015021-pol2qm74 2792 36 after after IN cord-015021-pol2qm74 2792 37 stimulation stimulation NN cord-015021-pol2qm74 2792 38 with with IN cord-015021-pol2qm74 2792 39 antigen antigen NN cord-015021-pol2qm74 2792 40 or or CC cord-015021-pol2qm74 2792 41 mitogen mitogen NNP cord-015021-pol2qm74 2792 42 and and CC cord-015021-pol2qm74 2792 43 established establish VBD cord-015021-pol2qm74 2792 44 Th Th NNP cord-015021-pol2qm74 2792 45 clones clone NNS cord-015021-pol2qm74 2792 46 are be VBP cord-015021-pol2qm74 2792 47 resistant resistant JJ cord-015021-pol2qm74 2792 48 to to IN cord-015021-pol2qm74 2792 49 the the DT cord-015021-pol2qm74 2792 50 priming priming NN cord-015021-pol2qm74 2792 51 effect effect NN cord-015021-pol2qm74 2792 52 of of IN cord-015021-pol2qm74 2792 53 IFN IFN NNP cord-015021-pol2qm74 2792 54 - - HYPH cord-015021-pol2qm74 2792 55 y y NNP cord-015021-pol2qm74 2792 56 . . . cord-015021-pol2qm74 2793 1 Unlike unlike IN cord-015021-pol2qm74 2793 2 the the DT cord-015021-pol2qm74 2793 3 generation generation NN cord-015021-pol2qm74 2793 4 of of IN cord-015021-pol2qm74 2793 5 high high JJ cord-015021-pol2qm74 2793 6 IFN IFN NNP cord-015021-pol2qm74 2793 7 - - HYPH cord-015021-pol2qm74 2793 8 y y NNP cord-015021-pol2qm74 2793 9 producing produce VBG cord-015021-pol2qm74 2793 10 clones clone NNS cord-015021-pol2qm74 2793 11 , , , cord-015021-pol2qm74 2793 12 the the DT cord-015021-pol2qm74 2793 13 IL-12-mediated il-12-mediated JJ cord-015021-pol2qm74 2793 14 inhibition inhibition NN cord-015021-pol2qm74 2793 15 of of IN cord-015021-pol2qm74 2793 16 IL-4 IL-4 NNP cord-015021-pol2qm74 2793 17 producing produce VBG cord-015021-pol2qm74 2793 18 cells cell NNS cord-015021-pol2qm74 2793 19 in in IN cord-015021-pol2qm74 2793 20 probably probably RB cord-015021-pol2qm74 2793 21 due due JJ cord-015021-pol2qm74 2793 22 to to IN cord-015021-pol2qm74 2793 23 selective selective JJ cord-015021-pol2qm74 2793 24 mechanisms mechanism NNS cord-015021-pol2qm74 2793 25 , , , cord-015021-pol2qm74 2793 26 which which WDT cord-015021-pol2qm74 2793 27 may may MD cord-015021-pol2qm74 2793 28 include include VB cord-015021-pol2qm74 2793 29 a a DT cord-015021-pol2qm74 2793 30 selective selective JJ cord-015021-pol2qm74 2793 31 mitegenic mitegenic JJ cord-015021-pol2qm74 2793 32 effect effect NN cord-015021-pol2qm74 2793 33 of of IN cord-015021-pol2qm74 2793 34 IL-12 IL-12 NNP cord-015021-pol2qm74 2793 35 for for IN cord-015021-pol2qm74 2793 36 Thl Thl NNP cord-015021-pol2qm74 2793 37 cells cell NNS cord-015021-pol2qm74 2793 38 and and CC cord-015021-pol2qm74 2793 39 an an DT cord-015021-pol2qm74 2793 40 inhibitory inhibitory JJ cord-015021-pol2qm74 2793 41 effect effect NN cord-015021-pol2qm74 2793 42 of of IN cord-015021-pol2qm74 2793 43 IFN IFN NNP cord-015021-pol2qm74 2793 44 - - HYPH cord-015021-pol2qm74 2793 45 y y NNP cord-015021-pol2qm74 2793 46 on on IN cord-015021-pol2qm74 2793 47 Th2 Th2 NNP cord-015021-pol2qm74 2793 48 cell cell NN cord-015021-pol2qm74 2793 49 proliferation proliferation NN cord-015021-pol2qm74 2793 50 . . . cord-015021-pol2qm74 2794 1 In in IN cord-015021-pol2qm74 2794 2 several several JJ cord-015021-pol2qm74 2794 3 experimental experimental JJ cord-015021-pol2qm74 2794 4 systems system NNS cord-015021-pol2qm74 2794 5 , , , cord-015021-pol2qm74 2794 6 it -PRON- PRP cord-015021-pol2qm74 2794 7 has have VBZ cord-015021-pol2qm74 2794 8 been be VBN cord-015021-pol2qm74 2794 9 shown show VBN cord-015021-pol2qm74 2794 10 that that IN cord-015021-pol2qm74 2794 11 the the DT cord-015021-pol2qm74 2794 12 enhancing enhance VBG cord-015021-pol2qm74 2794 13 effect effect NN cord-015021-pol2qm74 2794 14 of of IN cord-015021-pol2qm74 2794 15 IL-12 IL-12 NNP cord-015021-pol2qm74 2794 16 on on IN cord-015021-pol2qm74 2794 17 Th Th NNP cord-015021-pol2qm74 2794 18 - - HYPH cord-015021-pol2qm74 2794 19 i i PRP cord-015021-pol2qm74 2794 20 responses response NNS cord-015021-pol2qm74 2794 21 is be VBZ cord-015021-pol2qm74 2794 22 dependent dependent JJ cord-015021-pol2qm74 2794 23 on on IN cord-015021-pol2qm74 2794 24 production production NN cord-015021-pol2qm74 2794 25 of of IN cord-015021-pol2qm74 2794 26 IF~-y IF~-y NNP cord-015021-pol2qm74 2794 27 and and CC cord-015021-pol2qm74 2794 28 on on IN cord-015021-pol2qm74 2794 29 the the DT cord-015021-pol2qm74 2794 30 presence presence NN cord-015021-pol2qm74 2794 31 of of IN cord-015021-pol2qm74 2794 32 NK NK NNP cord-015021-pol2qm74 2794 33 cells cell NNS cord-015021-pol2qm74 2794 34 , , , cord-015021-pol2qm74 2794 35 possibly possibly RB cord-015021-pol2qm74 2794 36 needed need VBN cord-015021-pol2qm74 2794 37 for for IN cord-015021-pol2qm74 2794 38 the the DT cord-015021-pol2qm74 2794 39 early early JJ cord-015021-pol2qm74 2794 40 production production NN cord-015021-pol2qm74 2794 41 of of IN cord-015021-pol2qm74 2794 42 IFN IFN NNP cord-015021-pol2qm74 2794 43 - - HYPH cord-015021-pol2qm74 2794 44 y y NNP cord-015021-pol2qm74 2794 45 . . . cord-015021-pol2qm74 2795 1 The the DT cord-015021-pol2qm74 2795 2 importance importance NN cord-015021-pol2qm74 2795 3 of of IN cord-015021-pol2qm74 2795 4 phagocytic phagocytic JJ cord-015021-pol2qm74 2795 5 cells cell NNS cord-015021-pol2qm74 2795 6 and and CC cord-015021-pol2qm74 2795 7 NK NK NNP cord-015021-pol2qm74 2795 8 cells cell NNS cord-015021-pol2qm74 2795 9 in in IN cord-015021-pol2qm74 2795 10 determining determine VBG cord-015021-pol2qm74 2795 11 the the DT cord-015021-pol2qm74 2795 12 characteristics characteristic NNS cord-015021-pol2qm74 2795 13 of of IN cord-015021-pol2qm74 2795 14 the the DT cord-015021-pol2qm74 2795 15 Th Th NNP cord-015021-pol2qm74 2795 16 response response NN cord-015021-pol2qm74 2795 17 during during IN cord-015021-pol2qm74 2795 18 antigenic antigenic JJ cord-015021-pol2qm74 2795 19 stimulation stimulation NN cord-015021-pol2qm74 2795 20 indicated indicate VBD cord-015021-pol2qm74 2795 21 that that IN cord-015021-pol2qm74 2795 22 the the DT cord-015021-pol2qm74 2795 23 mechanisms mechanism NNS cord-015021-pol2qm74 2795 24 of of IN cord-015021-pol2qm74 2795 25 innate innate JJ cord-015021-pol2qm74 2795 26 resistance resistance NN cord-015021-pol2qm74 2795 27 have have VBP cord-015021-pol2qm74 2795 28 a a DT cord-015021-pol2qm74 2795 29 determining determine VBG cord-015021-pol2qm74 2795 30 influence influence NN cord-015021-pol2qm74 2795 31 on on IN cord-015021-pol2qm74 2795 32 the the DT cord-015021-pol2qm74 2795 33 subsequent subsequent JJ cord-015021-pol2qm74 2795 34 antigen antigen NN cord-015021-pol2qm74 2795 35 - - HYPH cord-015021-pol2qm74 2795 36 specific specific JJ cord-015021-pol2qm74 2795 37 immune immune JJ cord-015021-pol2qm74 2795 38 response response NN cord-015021-pol2qm74 2795 39 : : : cord-015021-pol2qm74 2795 40 IL-12 IL-12 NNP cord-015021-pol2qm74 2795 41 appears appear VBZ cord-015021-pol2qm74 2795 42 to to TO cord-015021-pol2qm74 2795 43 have have VB cord-015021-pol2qm74 2795 44 a a DT cord-015021-pol2qm74 2795 45 key key JJ cord-015021-pol2qm74 2795 46 role role NN cord-015021-pol2qm74 2795 47 in in IN cord-015021-pol2qm74 2795 48 mediating mediate VBG cord-015021-pol2qm74 2795 49 the the DT cord-015021-pol2qm74 2795 50 interaction interaction NN cord-015021-pol2qm74 2795 51 between between IN cord-015021-pol2qm74 2795 52 phagocytic phagocytic JJ cord-015021-pol2qm74 2795 53 cells cell NNS cord-015021-pol2qm74 2795 54 . . . cord-015021-pol2qm74 2796 1 NK NK NNP cord-015021-pol2qm74 2796 2 cells cell NNS cord-015021-pol2qm74 2796 3 , , , cord-015021-pol2qm74 2796 4 and and CC cord-015021-pol2qm74 2796 5 T T NNP cord-015021-pol2qm74 2796 6 lympocytes lympocyte NNS cord-015021-pol2qm74 2796 7 in in IN cord-015021-pol2qm74 2796 8 these these DT cord-015021-pol2qm74 2796 9 proccessem proccessem NN cord-015021-pol2qm74 2796 10 . . . cord-015021-pol2qm74 2797 1 Trinchieri Trinchieri NNP cord-015021-pol2qm74 2797 2 , , , cord-015021-pol2qm74 2797 3 G. G. NNP cord-015021-pol2qm74 2797 4 1993 1993 CD cord-015021-pol2qm74 2797 5 , , , cord-015021-pol2qm74 2797 6 Interleukin-12 Interleukin-12 NNP cord-015021-pol2qm74 2797 7 and and CC cord-015021-pol2qm74 2797 8 its -PRON- PRP$ cord-015021-pol2qm74 2797 9 role role NN cord-015021-pol2qm74 2797 10 in in IN cord-015021-pol2qm74 2797 11 the the DT cord-015021-pol2qm74 2797 12 generation generation NN cord-015021-pol2qm74 2797 13 of of IN cord-015021-pol2qm74 2797 14 T t NN cord-015021-pol2qm74 2797 15 E e NN cord-015021-pol2qm74 2797 16 1 1 CD cord-015021-pol2qm74 2797 17 cells cell NNS cord-015021-pol2qm74 2797 18 , , , cord-015021-pol2qm74 2797 19 Imm Imm NNP cord-015021-pol2qm74 2797 20 ~ ~ NFP cord-015021-pol2qm74 2797 21 ol ol UH cord-015021-pol2qm74 2797 22 . . . cord-015021-pol2qm74 2798 1 On on IN cord-015021-pol2qm74 2798 2 peripheral peripheral JJ cord-015021-pol2qm74 2798 3 blood blood NN cord-015021-pol2qm74 2798 4 monocyte monocyte NNP cord-015021-pol2qm74 2798 5 / / SYM cord-015021-pol2qm74 2798 6 macrophages macrophage NNS cord-015021-pol2qm74 2798 7 , , , cord-015021-pol2qm74 2798 8 IL-13 IL-13 NNP cord-015021-pol2qm74 2798 9 behaves behave VBZ cord-015021-pol2qm74 2798 10 like like IN cord-015021-pol2qm74 2798 11 IL-4 IL-4 NNP cord-015021-pol2qm74 2798 12 in in IN cord-015021-pol2qm74 2798 13 a a DT cord-015021-pol2qm74 2798 14 variety variety NN cord-015021-pol2qm74 2798 15 of of IN cord-015021-pol2qm74 2798 16 assays assay NNS cord-015021-pol2qm74 2798 17 , , , cord-015021-pol2qm74 2798 18 and and CC cord-015021-pol2qm74 2798 19 shows show VBZ cord-015021-pol2qm74 2798 20 both both CC cord-015021-pol2qm74 2798 21 similar similar JJ cord-015021-pol2qm74 2798 22 and and CC cord-015021-pol2qm74 2798 23 contrasting contrasting JJ cord-015021-pol2qm74 2798 24 , , , cord-015021-pol2qm74 2798 25 activties activtie NNS cord-015021-pol2qm74 2798 26 with with IN cord-015021-pol2qm74 2798 27 either either CC cord-015021-pol2qm74 2798 28 IL-10 IL-10 NNP cord-015021-pol2qm74 2798 29 or or CC cord-015021-pol2qm74 2798 30 IFN IFN NNP cord-015021-pol2qm74 2798 31 - - HYPH cord-015021-pol2qm74 2798 32 y y NNP cord-015021-pol2qm74 2798 33 . . . cord-015021-pol2qm74 2799 1 IL-13 IL-13 NNP cord-015021-pol2qm74 2799 2 reduces reduce VBZ cord-015021-pol2qm74 2799 3 inflammatory inflammatory JJ cord-015021-pol2qm74 2799 4 monokine monokine NN cord-015021-pol2qm74 2799 5 and and CC cord-015021-pol2qm74 2799 6 IL-10 IL-10 NNP cord-015021-pol2qm74 2799 7 production production NN cord-015021-pol2qm74 2799 8 . . . cord-015021-pol2qm74 2800 1 It -PRON- PRP cord-015021-pol2qm74 2800 2 reduces reduce VBZ cord-015021-pol2qm74 2800 3 the the DT cord-015021-pol2qm74 2800 4 pyrogen pyrogen NN cord-015021-pol2qm74 2800 5 - - HYPH cord-015021-pol2qm74 2800 6 induced induce VBN cord-015021-pol2qm74 2800 7 expression expression NN cord-015021-pol2qm74 2800 8 of of IN cord-015021-pol2qm74 2800 9 tissue tissue NN cord-015021-pol2qm74 2800 10 factor factor NN cord-015021-pol2qm74 2801 1 ( ( -LRB- cord-015021-pol2qm74 2801 2 Herbert Herbert NNP cord-015021-pol2qm74 2801 3 et et NNP cord-015021-pol2qm74 2801 4 el el NNP cord-015021-pol2qm74 2801 5 , , , cord-015021-pol2qm74 2801 6 1993 1993 CD cord-015021-pol2qm74 2801 7 , , , cord-015021-pol2qm74 2801 8 FEBS FEBS NNP cord-015021-pol2qm74 2801 9 Lett Lett NNP cord-015021-pol2qm74 2801 10 . . . cord-015021-pol2qm74 2802 1 328 328 CD cord-015021-pol2qm74 2802 2 , , , cord-015021-pol2qm74 2802 3 268 268 CD cord-015021-pol2qm74 2802 4 ) ) -RRB- cord-015021-pol2qm74 2802 5 . . . cord-015021-pol2qm74 2803 1 It -PRON- PRP cord-015021-pol2qm74 2803 2 mpregulates mpregulate VBZ cord-015021-pol2qm74 2803 3 manmose manmose JJ cord-015021-pol2qm74 2803 4 receptor receptor NN cord-015021-pol2qm74 2803 5 and and CC cord-015021-pol2qm74 2803 6 ~C ~C NFP cord-015021-pol2qm74 2803 7 class class NN cord-015021-pol2qm74 2803 8 II ii CD cord-015021-pol2qm74 2803 9 expression expression NN cord-015021-pol2qm74 2803 10 , , , cord-015021-pol2qm74 2803 11 while while IN cord-015021-pol2qm74 2803 12 reducing reduce VBG cord-015021-pol2qm74 2803 13 CDI4 CDI4 NNP cord-015021-pol2qm74 2803 14 expression expression NN cord-015021-pol2qm74 2803 15 . . . cord-015021-pol2qm74 2804 1 IL-13 IL-13 NNP cord-015021-pol2qm74 2804 2 produces produce VBZ cord-015021-pol2qm74 2804 3 morphological morphological JJ cord-015021-pol2qm74 2804 4 changes change NNS cord-015021-pol2qm74 2804 5 ( ( -LRB- cord-015021-pol2qm74 2804 6 extensive extensive JJ cord-015021-pol2qm74 2804 7 cell cell NN cord-015021-pol2qm74 2804 8 processes process NNS cord-015021-pol2qm74 2804 9 , , , cord-015021-pol2qm74 2804 10 aggregation aggregation NN cord-015021-pol2qm74 2804 11 , , , cord-015021-pol2qm74 2804 12 giant giant JJ cord-015021-pol2qm74 2804 13 cell cell NN cord-015021-pol2qm74 2804 14 formation formation NN cord-015021-pol2qm74 2804 15 ) ) -RRB- cord-015021-pol2qm74 2804 16 which which WDT cord-015021-pol2qm74 2804 17 have have VBP cord-015021-pol2qm74 2804 18 previously previously RB cord-015021-pol2qm74 2804 19 been be VBN cord-015021-pol2qm74 2804 20 observed observe VBN cord-015021-pol2qm74 2804 21 with with IN cord-015021-pol2qm74 2804 22 IL-4 IL-4 NNP cord-015021-pol2qm74 2804 23 . . . cord-015021-pol2qm74 2805 1 It -PRON- PRP cord-015021-pol2qm74 2805 2 inhibits inhibit VBZ cord-015021-pol2qm74 2805 3 NIV NIV NNP cord-015021-pol2qm74 2805 4 - - HYPH cord-015021-pol2qm74 2805 5 I i NN cord-015021-pol2qm74 2805 6 production production NN cord-015021-pol2qm74 2805 7 ( ( -LRB- cord-015021-pol2qm74 2805 8 Montaner Montaner NNP cord-015021-pol2qm74 2805 9 et et FW cord-015021-pol2qm74 2805 10 el el NNP cord-015021-pol2qm74 2805 11 , , , cord-015021-pol2qm74 2805 12 1993 1993 CD cord-015021-pol2qm74 2805 13 , , , cord-015021-pol2qm74 2805 14 I. I. NNP cord-015021-pol2qm74 2805 15 Exp Exp NNP cord-015021-pol2qm74 2805 16 . . . cord-015021-pol2qm74 2806 1 Mad mad JJ cord-015021-pol2qm74 2806 2 . . . cord-015021-pol2qm74 2807 1 178 178 CD cord-015021-pol2qm74 2807 2 , , , cord-015021-pol2qm74 2807 3 743 743 CD cord-015021-pol2qm74 2807 4 ) ) -RRB- cord-015021-pol2qm74 2807 5 , , , cord-015021-pol2qm74 2807 6 and and CC cord-015021-pol2qm74 2807 7 interferes interfere VBZ cord-015021-pol2qm74 2807 8 with with IN cord-015021-pol2qm74 2807 9 HIV HIV NNP cord-015021-pol2qm74 2807 10 - - HYPH cord-015021-pol2qm74 2807 11 induced induce VBN cord-015021-pol2qm74 2807 12 cell cell NN cord-015021-pol2qm74 2807 13 fusion fusion NN cord-015021-pol2qm74 2807 14 . . . cord-015021-pol2qm74 2808 1 The the DT cord-015021-pol2qm74 2808 2 activities activity NNS cord-015021-pol2qm74 2808 3 of of IN cord-015021-pol2qm74 2808 4 IL-13 IL-13 NNP cord-015021-pol2qm74 2808 5 and and CC cord-015021-pol2qm74 2808 6 IL-4 IL-4 NNP cord-015021-pol2qm74 2808 7 differ differ VBP cord-015021-pol2qm74 2808 8 on on IN cord-015021-pol2qm74 2808 9 T T NNP cord-015021-pol2qm74 2808 10 - - HYPH cord-015021-pol2qm74 2808 11 ly•ocyte ly•ocyte NNP cord-015021-pol2qm74 2808 12 and and CC cord-015021-pol2qm74 2808 13 large large JJ cord-015021-pol2qm74 2808 14 granular granular JJ cord-015021-pol2qm74 2808 15 lymphocyte lymphocyte NN cord-015021-pol2qm74 2808 16 population population NN cord-015021-pol2qm74 2808 17 . . . cord-015021-pol2qm74 2809 1 In in IN cord-015021-pol2qm74 2809 2 particular particular JJ cord-015021-pol2qm74 2809 3 IL-13 IL-13 NNP cord-015021-pol2qm74 2809 4 does do VBZ cord-015021-pol2qm74 2809 5 not not RB cord-015021-pol2qm74 2809 6 exhibit exhibit VB cord-015021-pol2qm74 2809 7 the the DT cord-015021-pol2qm74 2809 8 suppressive suppressive JJ cord-015021-pol2qm74 2809 9 effects effect NNS cord-015021-pol2qm74 2809 10 of of IN cord-015021-pol2qm74 2809 11 IL-4 IL-4 NNP cord-015021-pol2qm74 2809 12 on on IN cord-015021-pol2qm74 2809 13 THl THl NNP cord-015021-pol2qm74 2809 14 - - HYPH cord-015021-pol2qm74 2809 15 type type NN cord-015021-pol2qm74 2809 16 - - HYPH cord-015021-pol2qm74 2809 17 helper helper NN cord-015021-pol2qm74 2809 18 functions function NNS cord-015021-pol2qm74 2809 19 ( ( -LRB- cord-015021-pol2qm74 2809 20 IFNy IFNy NNP cord-015021-pol2qm74 2809 21 production production NN cord-015021-pol2qm74 2809 22 ) ) -RRB- cord-015021-pol2qm74 2809 23 and and CC cord-015021-pol2qm74 2809 24 cytotoxic cytotoxic JJ cord-015021-pol2qm74 2809 25 functions function NNS cord-015021-pol2qm74 2809 26 ( ( -LRB- cord-015021-pol2qm74 2809 27 perforin perforin NNP cord-015021-pol2qm74 2809 28 production production NN cord-015021-pol2qm74 2809 29 ) ) -RRB- cord-015021-pol2qm74 2809 30 . . . cord-015021-pol2qm74 2810 1 Data datum NNS cord-015021-pol2qm74 2810 2 will will MD cord-015021-pol2qm74 2810 3 be be VB cord-015021-pol2qm74 2810 4 presented present VBN cord-015021-pol2qm74 2810 5 showing show VBG cord-015021-pol2qm74 2810 6 that that IN cord-015021-pol2qm74 2810 7 IL-4 IL-4 NNP cord-015021-pol2qm74 2810 8 and and CC cord-015021-pol2qm74 2810 9 IL IL NNP cord-015021-pol2qm74 2810 10 - - HYPH cord-015021-pol2qm74 2810 11 l3 l3 NNP cord-015021-pol2qm74 2810 12 share share VBP cord-015021-pol2qm74 2810 13 a a DT cord-015021-pol2qm74 2810 14 common common JJ cord-015021-pol2qm74 2810 15 receptor receptor NN cord-015021-pol2qm74 2810 16 on on IN cord-015021-pol2qm74 2810 17 a a DT cord-015021-pol2qm74 2810 18 nu nu NN cord-015021-pol2qm74 2810 19 ~ ~ NNP cord-015021-pol2qm74 2810 20 er er UH cord-015021-pol2qm74 2810 21 of of IN cord-015021-pol2qm74 2810 22 cell cell NN cord-015021-pol2qm74 2810 23 types type NNS cord-015021-pol2qm74 2810 24 , , , cord-015021-pol2qm74 2810 25 but but CC cord-015021-pol2qm74 2810 26 not not RB cord-015021-pol2qm74 2810 27 on on IN cord-015021-pol2qm74 2810 28 T T NNP cord-015021-pol2qm74 2810 29 - - HYPH cord-015021-pol2qm74 2810 30 lympocytes lympocytes NNP cord-015021-pol2qm74 2810 31 ( ( -LRB- cord-015021-pol2qm74 2810 32 see see VB cord-015021-pol2qm74 2810 33 also also RB cord-015021-pol2qm74 2810 34 Zmrawski Zmrawski NNP cord-015021-pol2qm74 2810 35 st st NNP cord-015021-pol2qm74 2810 36 el el NNP cord-015021-pol2qm74 2810 37 . . NNP cord-015021-pol2qm74 2810 38 1993 1993 CD cord-015021-pol2qm74 2810 39 , , , cord-015021-pol2qm74 2810 40 EMBO EMBO NNP cord-015021-pol2qm74 2810 41 J.7 J.7 NNP cord-015021-pol2qm74 2810 42 . . . cord-015021-pol2qm74 2811 1 2663 2663 CD cord-015021-pol2qm74 2811 2 - - HYPH cord-015021-pol2qm74 2811 3 2670 2670 CD cord-015021-pol2qm74 2811 4 ) ) -RRB- cord-015021-pol2qm74 2811 5 , , , cord-015021-pol2qm74 2811 6 explaining explain VBG cord-015021-pol2qm74 2811 7 both both CC cord-015021-pol2qm74 2811 8 thai thai JJ cord-015021-pol2qm74 2811 9 common common JJ cord-015021-pol2qm74 2811 10 and and CC cord-015021-pol2qm74 2811 11 divergent divergent JJ cord-015021-pol2qm74 2811 12 activities activity NNS cord-015021-pol2qm74 2811 13 . . . cord-015021-pol2qm74 2812 1 The the DT cord-015021-pol2qm74 2812 2 levels level NNS cord-015021-pol2qm74 2812 3 of of IN cord-015021-pol2qm74 2812 4 IL-13~A il-13~a NN cord-015021-pol2qm74 2812 5 in in IN cord-015021-pol2qm74 2812 6 activated activate VBN cord-015021-pol2qm74 2812 7 peripheral peripheral JJ cord-015021-pol2qm74 2812 8 blood blood NN cord-015021-pol2qm74 2812 9 lymphocytes lymphocyte NNS cord-015021-pol2qm74 2812 10 are be VBP cord-015021-pol2qm74 2812 11 greater great JJR cord-015021-pol2qm74 2812 12 than than IN cord-015021-pol2qm74 2812 13 or or CC cord-015021-pol2qm74 2812 14 equivalent equivalent JJ cord-015021-pol2qm74 2812 15 to to IN cord-015021-pol2qm74 2812 16 those those DT cord-015021-pol2qm74 2812 17 of of IN cord-015021-pol2qm74 2812 18 IL-4 IL-4 NNP cord-015021-pol2qm74 2812 19 mP mP . cord-015021-pol2qm74 2813 1 ~JA ~JA NFP cord-015021-pol2qm74 2813 2 and and CC cord-015021-pol2qm74 2813 3 the the DT cord-015021-pol2qm74 2813 4 two two CD cord-015021-pol2qm74 2813 5 ml{NAs ml{nas CD cord-015021-pol2qm74 2813 6 are be VBP cord-015021-pol2qm74 2813 7 expressed express VBN cord-015021-pol2qm74 2813 8 by by IN cord-015021-pol2qm74 2813 9 different different JJ cord-015021-pol2qm74 2813 10 T T NNP cord-015021-pol2qm74 2813 11 lympocyte lympocyte NNP cord-015021-pol2qm74 2813 12 population population NN cord-015021-pol2qm74 2813 13 : : : cord-015021-pol2qm74 2813 14 in in IN cord-015021-pol2qm74 2813 15 particular particular JJ cord-015021-pol2qm74 2813 16 , , , cord-015021-pol2qm74 2813 17 T8 T8 NNP cord-015021-pol2qm74 2813 18 cytotoxic cytotoxic JJ cord-015021-pol2qm74 2813 19 lymphocytes lymphocyte NNS cord-015021-pol2qm74 2813 20 express express VBP cord-015021-pol2qm74 2813 21 markedly markedly RB cord-015021-pol2qm74 2813 22 higher high JJR cord-015021-pol2qm74 2813 23 levels level NNS cord-015021-pol2qm74 2813 24 of of IN cord-015021-pol2qm74 2813 25 IL-13~RNA IL-13~RNA NNPS cord-015021-pol2qm74 2813 26 . . . cord-015021-pol2qm74 2814 1 In in IN cord-015021-pol2qm74 2814 2 vivo vivo NN cord-015021-pol2qm74 2814 3 , , , cord-015021-pol2qm74 2814 4 IL-13 IL-13 NNP cord-015021-pol2qm74 2814 5 may may MD cord-015021-pol2qm74 2814 6 thus thus RB cord-015021-pol2qm74 2814 7 be be VB cord-015021-pol2qm74 2814 8 contributing contribute VBG cord-015021-pol2qm74 2814 9 , , , cord-015021-pol2qm74 2814 10 significantly significantly RB cord-015021-pol2qm74 2814 11 to to IN cord-015021-pol2qm74 2814 12 some some DT cord-015021-pol2qm74 2814 13 of of IN cord-015021-pol2qm74 2814 14 the the DT cord-015021-pol2qm74 2814 15 activites activite NNS cord-015021-pol2qm74 2814 16 previously previously RB cord-015021-pol2qm74 2814 17 ascribed ascribe VBN cord-015021-pol2qm74 2814 18 to to IN cord-015021-pol2qm74 2814 19 IL-4 IL-4 NNP cord-015021-pol2qm74 2814 20 IL-10 IL-10 NNP cord-015021-pol2qm74 2814 21 . . . cord-015021-pol2qm74 2815 1 Recently recently RB cord-015021-pol2qm74 2815 2 , , , cord-015021-pol2qm74 2815 3 we -PRON- PRP cord-015021-pol2qm74 2815 4 cloned clone VBD cord-015021-pol2qm74 2815 5 the the DT cord-015021-pol2qm74 2815 6 human human JJ cord-015021-pol2qm74 2815 7 cDNA cdna NN cord-015021-pol2qm74 2815 8 encoding encode VBG cord-015021-pol2qm74 2815 9 Interleukin-13 Interleukin-13 NNP cord-015021-pol2qm74 2815 10 ( ( -LRB- cord-015021-pol2qm74 2815 11 IL-13 IL-13 NNP cord-015021-pol2qm74 2815 12 ) ) -RRB- cord-015021-pol2qm74 2815 13 . . . cord-015021-pol2qm74 2816 1 Human Human NNP cord-015021-pol2qm74 2816 2 IL-13 IL-13 NNP cord-015021-pol2qm74 2816 3 is be VBZ cord-015021-pol2qm74 2816 4 a a DT cord-015021-pol2qm74 2816 5 non non JJ cord-015021-pol2qm74 2816 6 - - JJ cord-015021-pol2qm74 2816 7 glycosylated glycosylated JJ cord-015021-pol2qm74 2816 8 protein protein NN cord-015021-pol2qm74 2816 9 of of IN cord-015021-pol2qm74 2816 10 132 132 CD cord-015021-pol2qm74 2816 11 aa aa NN cord-015021-pol2qm74 2816 12 with with IN cord-015021-pol2qm74 2816 13 a a DT cord-015021-pol2qm74 2816 14 molecular molecular JJ cord-015021-pol2qm74 2816 15 mass mass NN cord-015021-pol2qm74 2816 16 ( ( -LRB- cord-015021-pol2qm74 2816 17 Mr Mr NNP cord-015021-pol2qm74 2816 18 ) ) -RRB- cord-015021-pol2qm74 2816 19 of of IN cord-015021-pol2qm74 2816 20 10 10 CD cord-015021-pol2qm74 2816 21 kD kD NNS cord-015021-pol2qm74 2816 22 and and CC cord-015021-pol2qm74 2816 23 has have VBZ cord-015021-pol2qm74 2816 24 biological biological JJ cord-015021-pol2qm74 2816 25 activities activity NNS cord-015021-pol2qm74 2816 26 on on IN cord-015021-pol2qm74 2816 27 monocytes monocyte NNS cord-015021-pol2qm74 2816 28 and and CC cord-015021-pol2qm74 2816 29 B b NN cord-015021-pol2qm74 2816 30 cells cell NNS cord-015021-pol2qm74 2816 31 , , , cord-015021-pol2qm74 2816 32 IL-13 IL-13 NNP cord-015021-pol2qm74 2816 33 , , , cord-015021-pol2qm74 2816 34 like like IN cord-015021-pol2qm74 2816 35 IL-4 IL-4 NNP cord-015021-pol2qm74 2816 36 , , , cord-015021-pol2qm74 2816 37 strongly strongly RB cord-015021-pol2qm74 2816 38 enhanced enhance VBD cord-015021-pol2qm74 2816 39 the the DT cord-015021-pol2qm74 2816 40 expression expression NN cord-015021-pol2qm74 2816 41 of of IN cord-015021-pol2qm74 2816 42 class class NN cord-015021-pol2qm74 2816 43 II II NNP cord-015021-pol2qm74 2816 44 MHC MHC NNP cord-015021-pol2qm74 2816 45 antigens antigen NNS cord-015021-pol2qm74 2816 46 on on IN cord-015021-pol2qm74 2816 47 monocytes monocyte NNS cord-015021-pol2qm74 2816 48 and and CC cord-015021-pol2qm74 2816 49 induced induce VBN cord-015021-pol2qm74 2816 50 expression expression NN cord-015021-pol2qm74 2816 51 of of IN cord-015021-pol2qm74 2816 52 CD23 CD23 NNP cord-015021-pol2qm74 2816 53 ( ( -LRB- cord-015021-pol2qm74 2816 54 Fc Fc NNP cord-015021-pol2qm74 2816 55 ~ ~ NNP cord-015021-pol2qm74 2816 56 RII RII NNP cord-015021-pol2qm74 2816 57 ) ) -RRB- cord-015021-pol2qm74 2816 58 . . . cord-015021-pol2qm74 2817 1 Furthermore furthermore RB cord-015021-pol2qm74 2817 2 , , , cord-015021-pol2qm74 2817 3 IL-13 IL-13 NNP cord-015021-pol2qm74 2817 4 , , , cord-015021-pol2qm74 2817 5 like like IN cord-015021-pol2qm74 2817 6 IL-4 IL-4 NNP cord-015021-pol2qm74 2817 7 and and CC cord-015021-pol2qm74 2817 8 IL~10 IL~10 NNP cord-015021-pol2qm74 2817 9 , , , cord-015021-pol2qm74 2817 10 inhibited inhibit VBD cord-015021-pol2qm74 2817 11 the the DT cord-015021-pol2qm74 2817 12 production production NN cord-015021-pol2qm74 2817 13 of of IN cord-015021-pol2qm74 2817 14 pro pro JJ cord-015021-pol2qm74 2817 15 - - JJ cord-015021-pol2qm74 2817 16 inflammatory inflammatory JJ cord-015021-pol2qm74 2817 17 cytokines cytokine NNS cord-015021-pol2qm74 2817 18 IL-1 IL-1 NNP cord-015021-pol2qm74 2817 19 , , , cord-015021-pol2qm74 2817 20 ] ] -RRB- cord-015021-pol2qm74 2817 21 L-6 L-6 NNP cord-015021-pol2qm74 2817 22 , , , cord-015021-pol2qm74 2817 23 TNFo~ TNFo~ NNP cord-015021-pol2qm74 2817 24 and and CC cord-015021-pol2qm74 2817 25 chemokines chemokine NNS cord-015021-pol2qm74 2817 26 MIPlc~ miplc~ NN cord-015021-pol2qm74 2817 27 and and CC cord-015021-pol2qm74 2817 28 tL-8 tl-8 NN cord-015021-pol2qm74 2817 29 by by IN cord-015021-pol2qm74 2817 30 LPS LPS NNP cord-015021-pol2qm74 2817 31 activated activate VBN cord-015021-pol2qm74 2817 32 monocytes monocyte NNS cord-015021-pol2qm74 2817 33 . . . cord-015021-pol2qm74 2818 1 Both both CC cord-015021-pol2qm74 2818 2 IL-13 IL-13 NNP cord-015021-pol2qm74 2818 3 and and CC cord-015021-pol2qm74 2818 4 IL-4 IL-4 NNP cord-015021-pol2qm74 2818 5 enhanced enhance VBD cord-015021-pol2qm74 2818 6 the the DT cord-015021-pol2qm74 2818 7 production production NN cord-015021-pol2qm74 2818 8 of of IN cord-015021-pol2qm74 2818 9 IL IL NNP cord-015021-pol2qm74 2818 10 - - HYPH cord-015021-pol2qm74 2818 11 lra lra NNP cord-015021-pol2qm74 2818 12 by by IN cord-015021-pol2qm74 2818 13 monocytes monocyte NNS cord-015021-pol2qm74 2818 14 . . . cord-015021-pol2qm74 2819 1 In in IN cord-015021-pol2qm74 2819 2 contrast contrast NN cord-015021-pol2qm74 2819 3 , , , cord-015021-pol2qm74 2819 4 IL-13 IL-13 NNP cord-015021-pol2qm74 2819 5 lacked lack VBD cord-015021-pol2qm74 2819 6 the the DT cord-015021-pol2qm74 2819 7 T t NN cord-015021-pol2qm74 2819 8 cell cell NN cord-015021-pol2qm74 2819 9 stimulating stimulate VBG cord-015021-pol2qm74 2819 10 activities activity NNS cord-015021-pol2qm74 2819 11 of of IN cord-015021-pol2qm74 2819 12 IL-4 IL-4 NNP cord-015021-pol2qm74 2819 13 . . . cord-015021-pol2qm74 2820 1 The the DT cord-015021-pol2qm74 2820 2 responses response NNS cord-015021-pol2qm74 2820 3 of of IN cord-015021-pol2qm74 2820 4 monocytes monocyte NNS cord-015021-pol2qm74 2820 5 to to IN cord-015021-pol2qm74 2820 6 IL-13 IL-13 NNP cord-015021-pol2qm74 2820 7 and and CC cord-015021-pol2qm74 2820 8 IL-4 IL-4 NNP cord-015021-pol2qm74 2820 9 were be VBD cord-015021-pol2qm74 2820 10 not not RB cord-015021-pol2qm74 2820 11 additive additive JJ cord-015021-pol2qm74 2820 12 or or CC cord-015021-pol2qm74 2820 13 synergistic synergistic JJ cord-015021-pol2qm74 2820 14 , , , cord-015021-pol2qm74 2820 15 supporting support VBG cord-015021-pol2qm74 2820 16 the the DT cord-015021-pol2qm74 2820 17 hypothesis hypothesis NN cord-015021-pol2qm74 2820 18 that that IN cord-015021-pol2qm74 2820 19 IL-13 IL-13 NNP cord-015021-pol2qm74 2820 20 and and CC cord-015021-pol2qm74 2820 21 IL-4 IL-4 NNP cord-015021-pol2qm74 2820 22 receptors receptor NNS cord-015021-pol2qm74 2820 23 are be VBP cord-015021-pol2qm74 2820 24 complex complex JJ cord-015021-pol2qm74 2820 25 and and CC cord-015021-pol2qm74 2820 26 share share VBP cord-015021-pol2qm74 2820 27 a a DT cord-015021-pol2qm74 2820 28 common common JJ cord-015021-pol2qm74 2820 29 component component NN cord-015021-pol2qm74 2820 30 which which WDT cord-015021-pol2qm74 2820 31 is be VBZ cord-015021-pol2qm74 2820 32 important important JJ cord-015021-pol2qm74 2820 33 for for IN cord-015021-pol2qm74 2820 34 signal signal NN cord-015021-pol2qm74 2820 35 transduction transduction NN cord-015021-pol2qm74 2820 36 , , , cord-015021-pol2qm74 2820 37 Taken take VBN cord-015021-pol2qm74 2820 38 together together RB cord-015021-pol2qm74 2820 39 , , , cord-015021-pol2qm74 2820 40 these these DT cord-015021-pol2qm74 2820 41 data datum NNS cord-015021-pol2qm74 2820 42 indicate indicate VBP cord-015021-pol2qm74 2820 43 that that IN cord-015021-pol2qm74 2820 44 IL-13 IL-13 NNP cord-015021-pol2qm74 2820 45 , , , cord-015021-pol2qm74 2820 46 IL~4 IL~4 NNP cord-015021-pol2qm74 2820 47 and and CC cord-015021-pol2qm74 2820 48 IL-10 IL-10 NNP cord-015021-pol2qm74 2820 49 have have VBP cord-015021-pol2qm74 2820 50 important important JJ cord-015021-pol2qm74 2820 51 anti anti JJ cord-015021-pol2qm74 2820 52 - - JJ cord-015021-pol2qm74 2820 53 inflammatory inflammatory JJ cord-015021-pol2qm74 2820 54 activities activity NNS cord-015021-pol2qm74 2820 55 on on IN cord-015021-pol2qm74 2820 56 human human JJ cord-015021-pol2qm74 2820 57 monocytes monocyte NNS cord-015021-pol2qm74 2820 58 . . . cord-015021-pol2qm74 2821 1 In in IN cord-015021-pol2qm74 2821 2 addition addition NN cord-015021-pol2qm74 2821 3 , , , cord-015021-pol2qm74 2821 4 these these DT cord-015021-pol2qm74 2821 5 results result NNS cord-015021-pol2qm74 2821 6 indicate indicate VBP cord-015021-pol2qm74 2821 7 that that IN cord-015021-pol2qm74 2821 8 IL-13 IL-13 NNP cord-015021-pol2qm74 2821 9 is be VBZ cord-015021-pol2qm74 2821 10 unique unique JJ cord-015021-pol2qm74 2821 11 in in IN cord-015021-pol2qm74 2821 12 that that IN cord-015021-pol2qm74 2821 13 it -PRON- PRP cord-015021-pol2qm74 2821 14 can can MD cord-015021-pol2qm74 2821 15 modify modify VB cord-015021-pol2qm74 2821 16 inflammatory inflammatory JJ cord-015021-pol2qm74 2821 17 reactions reaction NNS cord-015021-pol2qm74 2821 18 without without IN cord-015021-pol2qm74 2821 19 stimulating stimulate VBG cord-015021-pol2qm74 2821 20 ( ( -LRB- cord-015021-pol2qm74 2821 21 as as IN cord-015021-pol2qm74 2821 22 does do VBZ cord-015021-pol2qm74 2821 23 IL-4 IL-4 NNP cord-015021-pol2qm74 2821 24 ) ) -RRB- cord-015021-pol2qm74 2821 25 or or CC cord-015021-pol2qm74 2821 26 inhibiting inhibit VBG cord-015021-pol2qm74 2821 27 ( ( -LRB- cord-015021-pol2qm74 2821 28 as as IN cord-015021-pol2qm74 2821 29 does do VBZ cord-015021-pol2qm74 2821 30 IL-10 IL-10 NNP cord-015021-pol2qm74 2821 31 ) ) -RRB- cord-015021-pol2qm74 2821 32 T t NN cord-015021-pol2qm74 2821 33 cell cell NN cord-015021-pol2qm74 2821 34 responses response NNS cord-015021-pol2qm74 2821 35 . . . cord-015021-pol2qm74 2822 1 Transforming transform VBG cord-015021-pol2qm74 2822 2 growth growth NN cord-015021-pol2qm74 2822 3 factor factor NN cord-015021-pol2qm74 2822 4 beta beta NN cord-015021-pol2qm74 2822 5 I i NN cord-015021-pol2qm74 2822 6 ( ( -LRB- cord-015021-pol2qm74 2822 7 TGF TGF NNP cord-015021-pol2qm74 2822 8 - - HYPH cord-015021-pol2qm74 2822 9 fll fll NNP cord-015021-pol2qm74 2822 10 ) ) -RRB- cord-015021-pol2qm74 2822 11 belongs belong VBZ cord-015021-pol2qm74 2822 12 to to IN cord-015021-pol2qm74 2822 13 a a DT cord-015021-pol2qm74 2822 14 family family NN cord-015021-pol2qm74 2822 15 of of IN cord-015021-pol2qm74 2822 16 proteins protein NNS cord-015021-pol2qm74 2822 17 that that WDT cord-015021-pol2qm74 2822 18 have have VBP cord-015021-pol2qm74 2822 19 potent potent JJ cord-015021-pol2qm74 2822 20 immunoregulatory immunoregulatory JJ cord-015021-pol2qm74 2822 21 properties property NNS cord-015021-pol2qm74 2822 22 ranging range VBG cord-015021-pol2qm74 2822 23 ftom ftom JJ cord-015021-pol2qm74 2822 24 effects effect NNS cord-015021-pol2qm74 2822 25 on on IN cord-015021-pol2qm74 2822 26 the the DT cord-015021-pol2qm74 2822 27 growth growth NN cord-015021-pol2qm74 2822 28 and and CC cord-015021-pol2qm74 2822 29 dfflerentiafion dfflerentiafion NN cord-015021-pol2qm74 2822 30 of of IN cord-015021-pol2qm74 2822 31 primitive primitive JJ cord-015021-pol2qm74 2822 32 stem stem NN cord-015021-pol2qm74 2822 33 cells cell NNS cord-015021-pol2qm74 2822 34 to to IN cord-015021-pol2qm74 2822 35 the the DT cord-015021-pol2qm74 2822 36 differentiated differentiated JJ cord-015021-pol2qm74 2822 37 functions function NNS cord-015021-pol2qm74 2822 38 of of IN cord-015021-pol2qm74 2822 39 immune immune JJ cord-015021-pol2qm74 2822 40 system system NN cord-015021-pol2qm74 2822 41 effector effector NN cord-015021-pol2qm74 2822 42 cells cell NNS cord-015021-pol2qm74 2822 43 . . . cord-015021-pol2qm74 2823 1 TGF TGF NNP cord-015021-pol2qm74 2823 2 - - HYPH cord-015021-pol2qm74 2823 3 I I NNP cord-015021-pol2qm74 2824 1 ~I ~I NFP cord-015021-pol2qm74 2824 2 is be VBZ cord-015021-pol2qm74 2824 3 synthesized synthesize VBN cord-015021-pol2qm74 2824 4 as as IN cord-015021-pol2qm74 2824 5 a a DT cord-015021-pol2qm74 2824 6 large large JJ cord-015021-pol2qm74 2824 7 secretory secretory JJ cord-015021-pol2qm74 2824 8 precursor precursor NN cord-015021-pol2qm74 2824 9 polypeptide polypeptide NN cord-015021-pol2qm74 2824 10 of of IN cord-015021-pol2qm74 2824 11 390 390 CD cord-015021-pol2qm74 2824 12 amino amino JJ cord-015021-pol2qm74 2824 13 acids acid NNS cord-015021-pol2qm74 2824 14 that that WDT cord-015021-pol2qm74 2824 15 is be VBZ cord-015021-pol2qm74 2824 16 inactive inactive JJ cord-015021-pol2qm74 2824 17 until until IN cord-015021-pol2qm74 2824 18 processed process VBN cord-015021-pol2qm74 2824 19 to to IN cord-015021-pol2qm74 2824 20 a a DT cord-015021-pol2qm74 2824 21 disulfide disulfide NN cord-015021-pol2qm74 2824 22 linked link VBN cord-015021-pol2qm74 2824 23 homodimeric homodimeric JJ cord-015021-pol2qm74 2824 24 molecule molecule NN cord-015021-pol2qm74 2824 25 of of IN cord-015021-pol2qm74 2824 26 1t2 1t2 CD cord-015021-pol2qm74 2824 27 amino amino NN cord-015021-pol2qm74 2824 28 acids acid NNS cord-015021-pol2qm74 2824 29 each each DT cord-015021-pol2qm74 2824 30 . . . cord-015021-pol2qm74 2825 1 Recently recently RB cord-015021-pol2qm74 2825 2 it -PRON- PRP cord-015021-pol2qm74 2825 3 has have VBZ cord-015021-pol2qm74 2825 4 been be VBN cord-015021-pol2qm74 2825 5 found find VBN cord-015021-pol2qm74 2825 6 that that IN cord-015021-pol2qm74 2825 7 TGF-[~I tgf-[~i NN cord-015021-pol2qm74 2825 8 can can MD cord-015021-pol2qm74 2825 9 have have VB cord-015021-pol2qm74 2825 10 autocrine autocrine NN cord-015021-pol2qm74 2825 11 as as RB cord-015021-pol2qm74 2825 12 well well RB cord-015021-pol2qm74 2825 13 as as IN cord-015021-pol2qm74 2825 14 paracrine paracrine JJ cord-015021-pol2qm74 2825 15 effects effect NNS cord-015021-pol2qm74 2825 16 on on IN cord-015021-pol2qm74 2825 17 the the DT cord-015021-pol2qm74 2825 18 immune immune JJ cord-015021-pol2qm74 2825 19 system system NN cord-015021-pol2qm74 2825 20 indicating indicate VBG cord-015021-pol2qm74 2825 21 that that IN cord-015021-pol2qm74 2825 22 immune immune JJ cord-015021-pol2qm74 2825 23 cells cell NNS cord-015021-pol2qm74 2825 24 can can MD cord-015021-pol2qm74 2825 25 activate activate VB cord-015021-pol2qm74 2825 26 the the DT cord-015021-pol2qm74 2825 27 inactive inactive JJ cord-015021-pol2qm74 2825 28 secreted secrete VBN cord-015021-pol2qm74 2825 29 form form NN cord-015021-pol2qm74 2825 30 of of IN cord-015021-pol2qm74 2825 31 TGI~-~I. TGI~-~I. NNP cord-015021-pol2qm74 2826 1 In in IN cord-015021-pol2qm74 2826 2 addition addition NN cord-015021-pol2qm74 2826 3 , , , cord-015021-pol2qm74 2826 4 TGF TGF NNP cord-015021-pol2qm74 2826 5 - - HYPH cord-015021-pol2qm74 2826 6 I I NNP cord-015021-pol2qm74 2826 7 ~ ~ NFP cord-015021-pol2qm74 2826 8 I -PRON- PRP cord-015021-pol2qm74 2826 9 has have VBZ cord-015021-pol2qm74 2826 10 differential differential JJ cord-015021-pol2qm74 2826 11 intraceUular intraceuular JJ cord-015021-pol2qm74 2826 12 effects effect NNS cord-015021-pol2qm74 2826 13 on on IN cord-015021-pol2qm74 2826 14 cell cell NN cord-015021-pol2qm74 2826 15 surface surface NN cord-015021-pol2qm74 2826 16 receptor receptor NN cord-015021-pol2qm74 2826 17 modulation modulation NN cord-015021-pol2qm74 2826 18 , , , cord-015021-pol2qm74 2826 19 tyrosine tyrosine NN cord-015021-pol2qm74 2826 20 phosphorylation phosphorylation NN cord-015021-pol2qm74 2826 21 and and CC cord-015021-pol2qm74 2826 22 cytokine cytokine NN cord-015021-pol2qm74 2826 23 gene gene NN cord-015021-pol2qm74 2826 24 transcription transcription NN cord-015021-pol2qm74 2826 25 as as RB cord-015021-pol2qm74 2826 26 well well RB cord-015021-pol2qm74 2826 27 as as IN cord-015021-pol2qm74 2826 28 cell cell NN cord-015021-pol2qm74 2826 29 mediated mediate VBN cord-015021-pol2qm74 2826 30 cytotoxicity cytotoxicity NN cord-015021-pol2qm74 2826 31 . . . cord-015021-pol2qm74 2827 1 The the DT cord-015021-pol2qm74 2827 2 systemic systemic JJ cord-015021-pol2qm74 2827 3 administration administration NN cord-015021-pol2qm74 2827 4 of of IN cord-015021-pol2qm74 2827 5 TGF-131 TGF-131 NNP cord-015021-pol2qm74 2827 6 has have VBZ cord-015021-pol2qm74 2827 7 proven prove VBN cord-015021-pol2qm74 2827 8 beneficial beneficial JJ cord-015021-pol2qm74 2827 9 in in IN cord-015021-pol2qm74 2827 10 a a DT cord-015021-pol2qm74 2827 11 variety variety NN cord-015021-pol2qm74 2827 12 of of IN cord-015021-pol2qm74 2827 13 animal animal NN cord-015021-pol2qm74 2827 14 models model NNS cord-015021-pol2qm74 2827 15 such such JJ cord-015021-pol2qm74 2827 16 as as IN cord-015021-pol2qm74 2827 17 septic septic JJ cord-015021-pol2qm74 2827 18 shock shock NN cord-015021-pol2qm74 2827 19 , , , cord-015021-pol2qm74 2827 20 allograft allograft NN cord-015021-pol2qm74 2827 21 rejection rejection NN cord-015021-pol2qm74 2827 22 and and CC cord-015021-pol2qm74 2827 23 experimental experimental JJ cord-015021-pol2qm74 2827 24 forms form NNS cord-015021-pol2qm74 2827 25 of of IN cord-015021-pol2qm74 2827 26 autoimmunity autoimmunity NN cord-015021-pol2qm74 2827 27 including include VBG cord-015021-pol2qm74 2827 28 collagen collagen NN cord-015021-pol2qm74 2827 29 induced induce VBN cord-015021-pol2qm74 2827 30 arthritis arthritis NN cord-015021-pol2qm74 2827 31 and and CC cord-015021-pol2qm74 2827 32 experimental experimental JJ cord-015021-pol2qm74 2827 33 autoimmune autoimmune JJ cord-015021-pol2qm74 2827 34 encephalomyelitis encephalomyelitis NN cord-015021-pol2qm74 2827 35 . . . cord-015021-pol2qm74 2828 1 Moreover moreover RB cord-015021-pol2qm74 2828 2 the the DT cord-015021-pol2qm74 2828 3 increased increase VBN cord-015021-pol2qm74 2828 4 levels level NNS cord-015021-pol2qm74 2828 5 of of IN cord-015021-pol2qm74 2828 6 TGF TGF NNP cord-015021-pol2qm74 2829 1 -Ill -Ill : cord-015021-pol2qm74 2829 2 and and CC cord-015021-pol2qm74 2829 3 other other JJ cord-015021-pol2qm74 2829 4 TGF-13 tgf-13 CD cord-015021-pol2qm74 2829 5 isoforms isoform NNS cord-015021-pol2qm74 2829 6 found find VBN cord-015021-pol2qm74 2829 7 in in IN cord-015021-pol2qm74 2829 8 several several JJ cord-015021-pol2qm74 2829 9 disease disease NN cord-015021-pol2qm74 2829 10 states state NNS cord-015021-pol2qm74 2829 11 associated associate VBN cord-015021-pol2qm74 2829 12 with with IN cord-015021-pol2qm74 2829 13 immunosuppression immunosuppression NN cord-015021-pol2qm74 2829 14 such such JJ cord-015021-pol2qm74 2829 15 as as IN cord-015021-pol2qm74 2829 16 different different JJ cord-015021-pol2qm74 2829 17 forms form NNS cord-015021-pol2qm74 2829 18 of of IN cord-015021-pol2qm74 2829 19 malignancy malignancy NN cord-015021-pol2qm74 2829 20 , , , cord-015021-pol2qm74 2829 21 chronic chronic JJ cord-015021-pol2qm74 2829 22 degenerative degenerative JJ cord-015021-pol2qm74 2829 23 diseases disease NNS cord-015021-pol2qm74 2829 24 and and CC cord-015021-pol2qm74 2829 25 AIDS AIDS NNP cord-015021-pol2qm74 2829 26 implicate implicate VBP cord-015021-pol2qm74 2829 27 the the DT cord-015021-pol2qm74 2829 28 involvement involvement NN cord-015021-pol2qm74 2829 29 of of IN cord-015021-pol2qm74 2829 30 TGt~-I~ TGt~-I~ NNP cord-015021-pol2qm74 2829 31 in in IN cord-015021-pol2qm74 2829 32 the the DT cord-015021-pol2qm74 2829 33 pathogenesis pathogenesis NN cord-015021-pol2qm74 2829 34 of of IN cord-015021-pol2qm74 2829 35 some some DT cord-015021-pol2qm74 2829 36 diseases disease NNS cord-015021-pol2qm74 2829 37 . . . cord-015021-pol2qm74 2830 1 Hopefully hopefully RB cord-015021-pol2qm74 2830 2 , , , cord-015021-pol2qm74 2830 3 well well RB cord-015021-pol2qm74 2830 4 designed design VBN cord-015021-pol2qm74 2830 5 clinical clinical JJ cord-015021-pol2qm74 2830 6 trials trial NNS cord-015021-pol2qm74 2830 7 will will MD cord-015021-pol2qm74 2830 8 define define VB cord-015021-pol2qm74 2830 9 the the DT cord-015021-pol2qm74 2830 10 potential potential JJ cord-015021-pol2qm74 2830 11 roles role NNS cord-015021-pol2qm74 2830 12 of of IN cord-015021-pol2qm74 2830 13 the the DT cord-015021-pol2qm74 2830 14 TGF-[3 TGF-[3 NNP cord-015021-pol2qm74 2830 15 family family NN cord-015021-pol2qm74 2830 16 of of IN cord-015021-pol2qm74 2830 17 proteins protein NNS cord-015021-pol2qm74 2830 18 in in IN cord-015021-pol2qm74 2830 19 the the DT cord-015021-pol2qm74 2830 20 treatment treatment NN cord-015021-pol2qm74 2830 21 of of IN cord-015021-pol2qm74 2830 22 diseases disease NNS cord-015021-pol2qm74 2830 23 of of IN cord-015021-pol2qm74 2830 24 man man NN cord-015021-pol2qm74 2830 25 . . . cord-015021-pol2qm74 2831 1 Patient patient JJ cord-015021-pol2qm74 2831 2 development development NN cord-015021-pol2qm74 2831 3 of of IN cord-015021-pol2qm74 2831 4 systemic systemic JJ cord-015021-pol2qm74 2831 5 inflammatory inflammatory JJ cord-015021-pol2qm74 2831 6 response response NN cord-015021-pol2qm74 2831 7 syndrome syndrome NN cord-015021-pol2qm74 2831 8 ( ( -LRB- cord-015021-pol2qm74 2831 9 SIS SIS NNP cord-015021-pol2qm74 2831 10 ) ) -RRB- cord-015021-pol2qm74 2831 11 after after IN cord-015021-pol2qm74 2831 12 severe severe JJ cord-015021-pol2qm74 2831 13 trauma trauma NN cord-015021-pol2qm74 2831 14 is be VBZ cord-015021-pol2qm74 2831 15 accompanied accompany VBN cord-015021-pol2qm74 2831 16 by by IN cord-015021-pol2qm74 2831 17 a a DT cord-015021-pol2qm74 2831 18 wide wide JJ cord-015021-pol2qm74 2831 19 range range NN cord-015021-pol2qm74 2831 20 of of IN cord-015021-pol2qm74 2831 21 immune immune JJ cord-015021-pol2qm74 2831 22 aberrations aberration NNS cord-015021-pol2qm74 2831 23 and and CC cord-015021-pol2qm74 2831 24 altered alter VBN cord-015021-pol2qm74 2831 25 cytokine cytokine NN cord-015021-pol2qm74 2831 26 production production NN cord-015021-pol2qm74 2831 27 . . . cord-015021-pol2qm74 2832 1 In in IN cord-015021-pol2qm74 2832 2 particular particular JJ cord-015021-pol2qm74 2832 3 , , , cord-015021-pol2qm74 2832 4 T t NN cord-015021-pol2qm74 2832 5 lymphocyte lymphocyte NN cord-015021-pol2qm74 2832 6 proliferation proliferation NN cord-015021-pol2qm74 2832 7 and and CC cord-015021-pol2qm74 2832 8 IFN IFN NNP cord-015021-pol2qm74 2832 9 , , , cord-015021-pol2qm74 2832 10 t t NN cord-015021-pol2qm74 2832 11 production production NN cord-015021-pol2qm74 2832 12 is be VBZ cord-015021-pol2qm74 2832 13 suppressed suppress VBN cord-015021-pol2qm74 2832 14 while while IN cord-015021-pol2qm74 2832 15 monocyte monocyte NNP cord-015021-pol2qm74 2832 16 ( ( -LRB- cord-015021-pol2qm74 2832 17 MO MO NNP cord-015021-pol2qm74 2832 18 ) ) -RRB- cord-015021-pol2qm74 2833 1 TNFc~ TNFc~ NNP cord-015021-pol2qm74 2833 2 , , , cord-015021-pol2qm74 2833 3 IL-6 IL-6 NNP cord-015021-pol2qm74 2833 4 , , , cord-015021-pol2qm74 2833 5 PGE2 PGE2 NNP cord-015021-pol2qm74 2833 6 and and CC cord-015021-pol2qm74 2833 7 TGF~ TGF~ NNP cord-015021-pol2qm74 2833 8 production production NN cord-015021-pol2qm74 2833 9 is be VBZ cord-015021-pol2qm74 2833 10 massively massively RB cord-015021-pol2qm74 2833 11 increased increase VBN cord-015021-pol2qm74 2833 12 concomitant concomitant JJ cord-015021-pol2qm74 2833 13 to to IN cord-015021-pol2qm74 2833 14 decreased decrease VBN cord-015021-pol2qm74 2833 15 antigen antigen NN cord-015021-pol2qm74 2833 16 presenting present VBG cord-015021-pol2qm74 2833 17 capacity capacity NN cord-015021-pol2qm74 2833 18 . . . cord-015021-pol2qm74 2834 1 Recently recently RB cord-015021-pol2qm74 2834 2 , , , cord-015021-pol2qm74 2834 3 two two CD cord-015021-pol2qm74 2834 4 new new JJ cord-015021-pol2qm74 2834 5 cytokines cytokine NNS cord-015021-pol2qm74 2834 6 , , , cord-015021-pol2qm74 2834 7 IL-10 IL-10 NNP cord-015021-pol2qm74 2834 8 and and CC cord-015021-pol2qm74 2834 9 IL-12 IL-12 NNP cord-015021-pol2qm74 2834 10 , , , cord-015021-pol2qm74 2834 11 have have VBP cord-015021-pol2qm74 2834 12 been be VBN cord-015021-pol2qm74 2834 13 characterized characterize VBN cord-015021-pol2qm74 2834 14 as as IN cord-015021-pol2qm74 2834 15 critical critical JJ cord-015021-pol2qm74 2834 16 in in IN cord-015021-pol2qm74 2834 17 regulation regulation NN cord-015021-pol2qm74 2834 18 of of IN cord-015021-pol2qm74 2834 19 MO MO NNP cord-015021-pol2qm74 2834 20 TNFa TNFa NNP cord-015021-pol2qm74 2834 21 and and CC cord-015021-pol2qm74 2834 22 IL-6 IL-6 NNP cord-015021-pol2qm74 2834 23 , , , cord-015021-pol2qm74 2834 24 as as RB cord-015021-pol2qm74 2834 25 well well RB cord-015021-pol2qm74 2834 26 as as IN cord-015021-pol2qm74 2834 27 in in IN cord-015021-pol2qm74 2834 28 induction induction NN cord-015021-pol2qm74 2834 29 of of IN cord-015021-pol2qm74 2834 30 T t NN cord-015021-pol2qm74 2834 31 lymphocyte lymphocyte NN cord-015021-pol2qm74 2834 32 proliferation proliferation NN cord-015021-pol2qm74 2834 33 and and CC cord-015021-pol2qm74 2834 34 IFN IFN NNP cord-015021-pol2qm74 2834 35 7 7 CD cord-015021-pol2qm74 2834 36 production production NN cord-015021-pol2qm74 2834 37 . . . cord-015021-pol2qm74 2835 1 In in IN cord-015021-pol2qm74 2835 2 this this DT cord-015021-pol2qm74 2835 3 study study NN cord-015021-pol2qm74 2835 4 , , , cord-015021-pol2qm74 2835 5 peripheral peripheral JJ cord-015021-pol2qm74 2835 6 blood blood NN cord-015021-pol2qm74 2835 7 leukocytes leukocyte NNS cord-015021-pol2qm74 2835 8 ( ( -LRB- cord-015021-pol2qm74 2835 9 PBL PBL NNP cord-015021-pol2qm74 2835 10 ) ) -RRB- cord-015021-pol2qm74 2835 11 from from IN cord-015021-pol2qm74 2835 12 severe severe JJ cord-015021-pol2qm74 2835 13 trauma trauma NN cord-015021-pol2qm74 2835 14 patients patient NNS cord-015021-pol2qm74 2835 15 ( ( -LRB- cord-015021-pol2qm74 2835 16 Injury injury NN cord-015021-pol2qm74 2835 17 Severity severity NN cord-015021-pol2qm74 2835 18 Score score NN cord-015021-pol2qm74 2835 19 > > XX cord-015021-pol2qm74 2835 20 35 35 CD cord-015021-pol2qm74 2835 21 ) ) -RRB- cord-015021-pol2qm74 2835 22 were be VBD cord-015021-pol2qm74 2835 23 analyzed analyze VBN cord-015021-pol2qm74 2835 24 for for IN cord-015021-pol2qm74 2835 25 their -PRON- PRP$ cord-015021-pol2qm74 2835 26 IL-10 IL-10 NNP cord-015021-pol2qm74 2835 27 levels level NNS cord-015021-pol2qm74 2835 28 , , , cord-015021-pol2qm74 2835 29 their -PRON- PRP$ cord-015021-pol2qm74 2835 30 in in FW cord-015021-pol2qm74 2835 31 vitro vitro FW cord-015021-pol2qm74 2835 32 proliferation proliferation NN cord-015021-pol2qm74 2835 33 to to IN cord-015021-pol2qm74 2835 34 mitogen mitogen NNP cord-015021-pol2qm74 2835 35 ( ( -LRB- cord-015021-pol2qm74 2835 36 PHA PHA NNP cord-015021-pol2qm74 2835 37 ) ) -RRB- cord-015021-pol2qm74 2835 38 and and CC cord-015021-pol2qm74 2835 39 their -PRON- PRP$ cord-015021-pol2qm74 2835 40 response response NN cord-015021-pol2qm74 2835 41 after after IN cord-015021-pol2qm74 2835 42 IL-12 IL-12 NNP cord-015021-pol2qm74 2835 43 addition addition NN cord-015021-pol2qm74 2835 44 . . . cord-015021-pol2qm74 2836 1 Since since IN cord-015021-pol2qm74 2836 2 IL-10 IL-10 NNP cord-015021-pol2qm74 2836 3 produced produce VBD cord-015021-pol2qm74 2836 4 either either CC cord-015021-pol2qm74 2836 5 by by IN cord-015021-pol2qm74 2836 6 MO MO NNP cord-015021-pol2qm74 2836 7 or or CC cord-015021-pol2qm74 2836 8 by by IN cord-015021-pol2qm74 2836 9 T T NNP cord-015021-pol2qm74 2836 10 lymphocytes lymphocyte NNS cord-015021-pol2qm74 2836 11 can can MD cord-015021-pol2qm74 2836 12 depress depress VB cord-015021-pol2qm74 2836 13 M~ M~ NNP cord-015021-pol2qm74 2836 14 antigen antigen NN cord-015021-pol2qm74 2836 15 presenting present VBG cord-015021-pol2qm74 2836 16 capacity capacity NN cord-015021-pol2qm74 2836 17 , , , cord-015021-pol2qm74 2836 18 inhibit inhibit VB cord-015021-pol2qm74 2836 19 T t NN cord-015021-pol2qm74 2836 20 cell cell NN cord-015021-pol2qm74 2836 21 IFN,/production ifn,/production NN cord-015021-pol2qm74 2836 22 and and CC cord-015021-pol2qm74 2836 23 directly directly RB cord-015021-pol2qm74 2836 24 diminish diminish VB cord-015021-pol2qm74 2836 25 T t NN cord-015021-pol2qm74 2836 26 cell cell NN cord-015021-pol2qm74 2836 27 proliferation proliferation NN cord-015021-pol2qm74 2836 28 , , , cord-015021-pol2qm74 2836 29 it -PRON- PRP cord-015021-pol2qm74 2836 30 might may MD cord-015021-pol2qm74 2836 31 be be VB cord-015021-pol2qm74 2836 32 suggested suggest VBN cord-015021-pol2qm74 2836 33 that that IN cord-015021-pol2qm74 2836 34 immunosuppressed immunosuppressed JJ cord-015021-pol2qm74 2836 35 patients patient NNS cord-015021-pol2qm74 2836 36 ' ' POS cord-015021-pol2qm74 2836 37 MO MO NNP cord-015021-pol2qm74 2836 38 and/or and/or CC cord-015021-pol2qm74 2836 39 T T NNP cord-015021-pol2qm74 2836 40 lymphocytes lymphocyte NNS cord-015021-pol2qm74 2836 41 would would MD cord-015021-pol2qm74 2836 42 have have VB cord-015021-pol2qm74 2836 43 increased increase VBN cord-015021-pol2qm74 2836 44 IL-10 IL-10 NNP cord-015021-pol2qm74 2836 45 levels level NNS cord-015021-pol2qm74 2836 46 . . . cord-015021-pol2qm74 2837 1 Increased increase VBN cord-015021-pol2qm74 2837 2 patient patient NN cord-015021-pol2qm74 2837 3 IL-10 IL-10 NNP cord-015021-pol2qm74 2837 4 production production NN cord-015021-pol2qm74 2837 5 might may MD cord-015021-pol2qm74 2837 6 also also RB cord-015021-pol2qm74 2837 7 be be VB cord-015021-pol2qm74 2837 8 resulting result VBG cord-015021-pol2qm74 2837 9 from from IN cord-015021-pol2qm74 2837 10 the the DT cord-015021-pol2qm74 2837 11 high high JJ cord-015021-pol2qm74 2837 12 levels level NNS cord-015021-pol2qm74 2837 13 of of IN cord-015021-pol2qm74 2837 14 TNFa TNFa NNS cord-015021-pol2qm74 2837 15 a a DT cord-015021-pol2qm74 2837 16 known know VBN cord-015021-pol2qm74 2837 17 stimulator stimulator NN cord-015021-pol2qm74 2837 18 of of IN cord-015021-pol2qm74 2837 19 IL-10 IL-10 NNP cord-015021-pol2qm74 2837 20 . . . cord-015021-pol2qm74 2838 1 Conversely conversely RB cord-015021-pol2qm74 2838 2 , , , cord-015021-pol2qm74 2838 3 since since IN cord-015021-pol2qm74 2838 4 IL-12 IL-12 NNP cord-015021-pol2qm74 2838 5 augments augment VBZ cord-015021-pol2qm74 2838 6 MO MO NNP cord-015021-pol2qm74 2838 7 antigenpresenting antigenpresenting NN cord-015021-pol2qm74 2838 8 capacity capacity NN cord-015021-pol2qm74 2838 9 , , , cord-015021-pol2qm74 2838 10 Thl Thl NNP cord-015021-pol2qm74 2838 11 induction induction NN cord-015021-pol2qm74 2838 12 and and CC cord-015021-pol2qm74 2838 13 proliferation proliferation NN cord-015021-pol2qm74 2838 14 , , , cord-015021-pol2qm74 2838 15 post post JJ cord-015021-pol2qm74 2838 16 - - JJ cord-015021-pol2qm74 2838 17 trauma trauma JJ cord-015021-pol2qm74 2838 18 leukocytes leukocyte NNS cord-015021-pol2qm74 2838 19 might may MD cord-015021-pol2qm74 2838 20 be be VB cord-015021-pol2qm74 2838 21 IL-12 IL-12 NNP cord-015021-pol2qm74 2838 22 deficient deficient JJ cord-015021-pol2qm74 2838 23 . . . cord-015021-pol2qm74 2839 1 PBL PBL NNP cord-015021-pol2qm74 2839 2 of of IN cord-015021-pol2qm74 2839 3 trauma trauma NN cord-015021-pol2qm74 2839 4 patients patient NNS cord-015021-pol2qm74 2839 5 were be VBD cord-015021-pol2qm74 2839 6 compared compare VBN cord-015021-pol2qm74 2839 7 to to IN cord-015021-pol2qm74 2839 8 normals normal NNS cord-015021-pol2qm74 2839 9 ' ' POS cord-015021-pol2qm74 2839 10 PBL PBL NNP cord-015021-pol2qm74 2839 11 , , , cord-015021-pol2qm74 2839 12 either either CC cord-015021-pol2qm74 2839 13 unstimulated unstimulated JJ cord-015021-pol2qm74 2839 14 or or CC cord-015021-pol2qm74 2839 15 PttA PttA NNP cord-015021-pol2qm74 2839 16 induced induce VBN cord-015021-pol2qm74 2839 17 , , , cord-015021-pol2qm74 2839 18 and and CC cord-015021-pol2qm74 2839 19 their -PRON- PRP$ cord-015021-pol2qm74 2839 20 levels level NNS cord-015021-pol2qm74 2839 21 of of IN cord-015021-pol2qm74 2839 22 IL-10 IL-10 NNP cord-015021-pol2qm74 2839 23 found find VBD cord-015021-pol2qm74 2839 24 to to TO cord-015021-pol2qm74 2839 25 be be VB cord-015021-pol2qm74 2839 26 dramatically dramatically RB cord-015021-pol2qm74 2839 27 and and CC cord-015021-pol2qm74 2839 28 significantly significantly RB cord-015021-pol2qm74 2839 29 reduced reduce VBN cord-015021-pol2qm74 2839 30 . . . cord-015021-pol2qm74 2840 1 Patients patient NNS cord-015021-pol2qm74 2840 2 ' ' POS cord-015021-pol2qm74 2840 3 isolated isolate VBN cord-015021-pol2qm74 2840 4 M~ m~ NN cord-015021-pol2qm74 2840 5 , , , cord-015021-pol2qm74 2840 6 either either CC cord-015021-pol2qm74 2840 7 stimulated stimulate VBN cord-015021-pol2qm74 2840 8 with with IN cord-015021-pol2qm74 2840 9 the the DT cord-015021-pol2qm74 2840 10 bacterial bacterial JJ cord-015021-pol2qm74 2840 11 cell cell NN cord-015021-pol2qm74 2840 12 wall wall NN cord-015021-pol2qm74 2840 13 analogue analogue NNP cord-015021-pol2qm74 2840 14 , , , cord-015021-pol2qm74 2840 15 MDP MDP NNP cord-015021-pol2qm74 2840 16 , , , cord-015021-pol2qm74 2840 17 or or CC cord-015021-pol2qm74 2840 18 unstimulated unstimulated JJ cord-015021-pol2qm74 2840 19 , , , cord-015021-pol2qm74 2840 20 also also RB cord-015021-pol2qm74 2840 21 had have VBD cord-015021-pol2qm74 2840 22 depressed depress VBN cord-015021-pol2qm74 2840 23 IL-10 IL-10 NNP cord-015021-pol2qm74 2840 24 production production NN cord-015021-pol2qm74 2840 25 concomitant concomitant JJ cord-015021-pol2qm74 2840 26 to to IN cord-015021-pol2qm74 2840 27 elevated elevated JJ cord-015021-pol2qm74 2840 28 TNFa TNFa NNS cord-015021-pol2qm74 2840 29 production production NN cord-015021-pol2qm74 2840 30 when when WRB cord-015021-pol2qm74 2840 31 compared compare VBN cord-015021-pol2qm74 2840 32 to to IN cord-015021-pol2qm74 2840 33 normals normal NNS cord-015021-pol2qm74 2840 34 ' ' POS cord-015021-pol2qm74 2840 35 MO MO NNP cord-015021-pol2qm74 2840 36 . . . cord-015021-pol2qm74 2841 1 Mechanisms mechanism NNS cord-015021-pol2qm74 2841 2 for for IN cord-015021-pol2qm74 2841 3 the the DT cord-015021-pol2qm74 2841 4 depressed depressed JJ cord-015021-pol2qm74 2841 5 patients patient NNS cord-015021-pol2qm74 2841 6 ' ' POS cord-015021-pol2qm74 2841 7 MO MO NNP cord-015021-pol2qm74 2841 8 IL-10 IL-10 NNP cord-015021-pol2qm74 2841 9 were be VBD cord-015021-pol2qm74 2841 10 explored explore VBN cord-015021-pol2qm74 2841 11 . . . cord-015021-pol2qm74 2842 1 Increases increase NNS cord-015021-pol2qm74 2842 2 in in IN cord-015021-pol2qm74 2842 3 TGF[3 TGF[3 NNP cord-015021-pol2qm74 2842 4 may may MD cord-015021-pol2qm74 2842 5 have have VB cord-015021-pol2qm74 2842 6 partially partially RB cord-015021-pol2qm74 2842 7 contributed contribute VBN cord-015021-pol2qm74 2842 8 to to IN cord-015021-pol2qm74 2842 9 the the DT cord-015021-pol2qm74 2842 10 patients patient NNS cord-015021-pol2qm74 2842 11 ' ' POS cord-015021-pol2qm74 2842 12 depressed depressed JJ cord-015021-pol2qm74 2842 13 IL-10 IL-10 NNP cord-015021-pol2qm74 2842 14 level level NN cord-015021-pol2qm74 2842 15 , , , cord-015021-pol2qm74 2842 16 but but CC cord-015021-pol2qm74 2842 17 elevated elevated JJ cord-015021-pol2qm74 2842 18 PGE2 PGE2 NNP cord-015021-pol2qm74 2842 19 had have VBD cord-015021-pol2qm74 2842 20 no no DT cord-015021-pol2qm74 2842 21 effect effect NN cord-015021-pol2qm74 2842 22 . . . cord-015021-pol2qm74 2843 1 Addition addition NN cord-015021-pol2qm74 2843 2 of of IN cord-015021-pol2qm74 2843 3 IL-12 IL-12 NNP cord-015021-pol2qm74 2843 4 to to IN cord-015021-pol2qm74 2843 5 patients patient NNS cord-015021-pol2qm74 2843 6 ' ' POS cord-015021-pol2qm74 2843 7 PBL PBL NNP cord-015021-pol2qm74 2843 8 significantly significantly RB cord-015021-pol2qm74 2843 9 increased increase VBD cord-015021-pol2qm74 2843 10 their -PRON- PRP$ cord-015021-pol2qm74 2843 11 mitogen mitogen NN cord-015021-pol2qm74 2843 12 responses response NNS cord-015021-pol2qm74 2843 13 . . . cord-015021-pol2qm74 2844 1 These these DT cord-015021-pol2qm74 2844 2 data datum NNS cord-015021-pol2qm74 2844 3 imply imply VBP cord-015021-pol2qm74 2844 4 that that IN cord-015021-pol2qm74 2844 5 SIS SIS NNP cord-015021-pol2qm74 2844 6 is be VBZ cord-015021-pol2qm74 2844 7 characterized characterize VBN cord-015021-pol2qm74 2844 8 by by IN cord-015021-pol2qm74 2844 9 disruption disruption NN cord-015021-pol2qm74 2844 10 in in IN cord-015021-pol2qm74 2844 11 the the DT cord-015021-pol2qm74 2844 12 interactions interaction NNS cord-015021-pol2qm74 2844 13 between between IN cord-015021-pol2qm74 2844 14 MCi MCi NNS cord-015021-pol2qm74 2844 15 and and CC cord-015021-pol2qm74 2844 16 T t NN cord-015021-pol2qm74 2844 17 lymphocytes lymphocyte NNS cord-015021-pol2qm74 2844 18 so so IN cord-015021-pol2qm74 2844 19 that that IN cord-015021-pol2qm74 2844 20 patients patient NNS cord-015021-pol2qm74 2844 21 ' ' POS cord-015021-pol2qm74 2844 22 M m NN cord-015021-pol2qm74 2845 1 ~i ~i NNP cord-015021-pol2qm74 2845 2 produce produce VB cord-015021-pol2qm74 2845 3 excesses excess NNS cord-015021-pol2qm74 2845 4 of of IN cord-015021-pol2qm74 2845 5 some some DT cord-015021-pol2qm74 2845 6 mediators mediator NNS cord-015021-pol2qm74 2845 7 ( ( -LRB- cord-015021-pol2qm74 2845 8 TNFa TNFa NNP cord-015021-pol2qm74 2845 9 , , , cord-015021-pol2qm74 2845 10 IL-6 IL-6 NNP cord-015021-pol2qm74 2845 11 , , , cord-015021-pol2qm74 2845 12 PGE2 PGE2 NNP cord-015021-pol2qm74 2845 13 ) ) -RRB- cord-015021-pol2qm74 2845 14 and and CC cord-015021-pol2qm74 2845 15 a a DT cord-015021-pol2qm74 2845 16 dearth dearth NN cord-015021-pol2qm74 2845 17 of of IN cord-015021-pol2qm74 2845 18 other other JJ cord-015021-pol2qm74 2845 19 monokines monokine NNS cord-015021-pol2qm74 2845 20 ( ( -LRB- cord-015021-pol2qm74 2845 21 IL-12 IL-12 NNP cord-015021-pol2qm74 2845 22 , , , cord-015021-pol2qm74 2845 23 IL IL NNP cord-015021-pol2qm74 2845 24 - - HYPH cord-015021-pol2qm74 2845 25 IO IO NNP cord-015021-pol2qm74 2845 26 ) ) -RRB- cord-015021-pol2qm74 2845 27 . . . cord-015021-pol2qm74 2846 1 T T NNP cord-015021-pol2qm74 2846 2 lymphocytes lymphocyte NNS cord-015021-pol2qm74 2846 3 are be VBP cord-015021-pol2qm74 2846 4 not not RB cord-015021-pol2qm74 2846 5 activated activate VBN cord-015021-pol2qm74 2846 6 and and CC cord-015021-pol2qm74 2846 7 , , , cord-015021-pol2qm74 2846 8 therefore therefore RB cord-015021-pol2qm74 2846 9 , , , cord-015021-pol2qm74 2846 10 unable unable JJ cord-015021-pol2qm74 2846 11 to to TO cord-015021-pol2qm74 2846 12 function function VB cord-015021-pol2qm74 2846 13 in in IN cord-015021-pol2qm74 2846 14 both both DT cord-015021-pol2qm74 2846 15 immune immune JJ cord-015021-pol2qm74 2846 16 defense defense NN cord-015021-pol2qm74 2846 17 and and CC cord-015021-pol2qm74 2846 18 monocyte monocyte NNP cord-015021-pol2qm74 2846 19 regulation regulation NN cord-015021-pol2qm74 2846 20 . . . cord-015021-pol2qm74 2847 1 It -PRON- PRP cord-015021-pol2qm74 2847 2 is be VBZ cord-015021-pol2qm74 2847 3 known know VBN cord-015021-pol2qm74 2847 4 that that IN cord-015021-pol2qm74 2847 5 lgE lge JJ cord-015021-pol2qm74 2847 6 receptor receptor NN cord-015021-pol2qm74 2847 7 - - HYPH cord-015021-pol2qm74 2847 8 mediated mediate VBN cord-015021-pol2qm74 2847 9 or or CC cord-015021-pol2qm74 2847 10 Ca Ca NNP cord-015021-pol2qm74 2847 11 - - HYPH cord-015021-pol2qm74 2847 12 ionophore ionophore RB cord-015021-pol2qm74 2847 13 - - HYPH cord-015021-pol2qm74 2847 14 induced induce VBN cord-015021-pol2qm74 2847 15 activation activation NN cord-015021-pol2qm74 2847 16 of of IN cord-015021-pol2qm74 2847 17 mouse mouse NN cord-015021-pol2qm74 2847 18 bone bone NN cord-015021-pol2qm74 2847 19 marrow marrow NN cord-015021-pol2qm74 2847 20 - - HYPH cord-015021-pol2qm74 2847 21 derived derive VBN cord-015021-pol2qm74 2847 22 mast mast NN cord-015021-pol2qm74 2847 23 cells cell NNS cord-015021-pol2qm74 2847 24 ( ( -LRB- cord-015021-pol2qm74 2847 25 13MMC 13mmc CD cord-015021-pol2qm74 2847 26 ) ) -RRB- cord-015021-pol2qm74 2847 27 may may MD cord-015021-pol2qm74 2847 28 result result VB cord-015021-pol2qm74 2847 29 in in IN cord-015021-pol2qm74 2847 30 the the DT cord-015021-pol2qm74 2847 31 production production NN cord-015021-pol2qm74 2847 32 of of IN cord-015021-pol2qm74 2847 33 different different JJ cord-015021-pol2qm74 2847 34 cytokines cytokine NNS cord-015021-pol2qm74 2847 35 including include VBG cord-015021-pol2qm74 2847 36 the the DT cord-015021-pol2qm74 2847 37 interleukins interleukin NNS cord-015021-pol2qm74 2847 38 ( ( -LRB- cord-015021-pol2qm74 2847 39 IL IL NNP cord-015021-pol2qm74 2847 40 ) ) -RRB- cord-015021-pol2qm74 2847 41 3 3 CD cord-015021-pol2qm74 2847 42 , , , cord-015021-pol2qm74 2847 43 4 4 CD cord-015021-pol2qm74 2847 44 , , , cord-015021-pol2qm74 2847 45 5 5 CD cord-015021-pol2qm74 2847 46 , , , cord-015021-pol2qm74 2847 47 and and CC cord-015021-pol2qm74 2847 48 6 6 CD cord-015021-pol2qm74 2847 49 as as RB cord-015021-pol2qm74 2847 50 well well RB cord-015021-pol2qm74 2847 51 as as IN cord-015021-pol2qm74 2847 52 GM GM NNP cord-015021-pol2qm74 2847 53 - - HYPH cord-015021-pol2qm74 2847 54 CSF CSF NNP cord-015021-pol2qm74 2847 55 and and CC cord-015021-pol2qm74 2847 56 TNF TNF NNP cord-015021-pol2qm74 2847 57 - - HYPH cord-015021-pol2qm74 2847 58 a a NNP cord-015021-pol2qm74 2847 59 . . . cord-015021-pol2qm74 2848 1 In in IN cord-015021-pol2qm74 2848 2 the the DT cord-015021-pol2qm74 2848 3 present present JJ cord-015021-pol2qm74 2848 4 study study NN cord-015021-pol2qm74 2848 5 we -PRON- PRP cord-015021-pol2qm74 2848 6 analyzed analyze VBD cord-015021-pol2qm74 2848 7 the the DT cord-015021-pol2qm74 2848 8 effects effect NNS cord-015021-pol2qm74 2848 9 of of IN cord-015021-pol2qm74 2848 10 exogeneously exogeneously NN cord-015021-pol2qm74 2848 11 applied apply VBN cord-015021-pol2qm74 2848 12 pro pro JJ cord-015021-pol2qm74 2848 13 - - JJ cord-015021-pol2qm74 2848 14 inflammatory inflammatory JJ cord-015021-pol2qm74 2848 15 cytokines cytokine NNS cord-015021-pol2qm74 2848 16 ( ( -LRB- cord-015021-pol2qm74 2848 17 IL-1 IL-1 NNP cord-015021-pol2qm74 2848 18 , , , cord-015021-pol2qm74 2848 19 1L-6 1l-6 CD cord-015021-pol2qm74 2848 20 , , , cord-015021-pol2qm74 2848 21 TNF TNF NNP cord-015021-pol2qm74 2848 22 - - HYPH cord-015021-pol2qm74 2848 23 c c NNP cord-015021-pol2qm74 2848 24 0 0 NFP cord-015021-pol2qm74 2848 25 as as RB cord-015021-pol2qm74 2848 26 well well RB cord-015021-pol2qm74 2848 27 as as IN cord-015021-pol2qm74 2848 28 various various JJ cord-015021-pol2qm74 2848 29 mast mast JJ cord-015021-pol2qm74 2848 30 cell cell NN cord-015021-pol2qm74 2848 31 growth growth NN cord-015021-pol2qm74 2848 32 factors factor NNS cord-015021-pol2qm74 2848 33 ( ( -LRB- cord-015021-pol2qm74 2848 34 IL-3 IL-3 NNP cord-015021-pol2qm74 2848 35 , , , cord-015021-pol2qm74 2848 36 IL-4 IL-4 NNP cord-015021-pol2qm74 2848 37 , , , cord-015021-pol2qm74 2848 38 IL-9 IL-9 NNP cord-015021-pol2qm74 2848 39 , , , cord-015021-pol2qm74 2848 40 IL-10 IL-10 NNP cord-015021-pol2qm74 2848 41 , , , cord-015021-pol2qm74 2848 42 NGF NGF NNP cord-015021-pol2qm74 2848 43 , , , cord-015021-pol2qm74 2848 44 KL KL NNP cord-015021-pol2qm74 2848 45 ( ( -LRB- cord-015021-pol2qm74 2848 46 kit kit NN cord-015021-pol2qm74 2848 47 ligand ligand NN cord-015021-pol2qm74 2848 48 ) ) -RRB- cord-015021-pol2qm74 2848 49 ) ) -RRB- cord-015021-pol2qm74 2848 50 on on IN cord-015021-pol2qm74 2848 51 cytokine cytokine NN cord-015021-pol2qm74 2848 52 production production NN cord-015021-pol2qm74 2848 53 in in IN cord-015021-pol2qm74 2848 54 primary primary JJ cord-015021-pol2qm74 2848 55 mouse mouse NN cord-015021-pol2qm74 2848 56 BMMC BMMC NNP cord-015021-pol2qm74 2848 57 using use VBG cord-015021-pol2qm74 2848 58 a a DT cord-015021-pol2qm74 2848 59 standard standard JJ cord-015021-pol2qm74 2848 60 activation activation NN cord-015021-pol2qm74 2848 61 protocol protocol NN cord-015021-pol2qm74 2848 62 ( ( -LRB- cord-015021-pol2qm74 2848 63 lxl06 lxl06 NNP cord-015021-pol2qm74 2848 64 BMMC BMMC NNP cord-015021-pol2qm74 2848 65 / / SYM cord-015021-pol2qm74 2848 66 ml ml XX cord-015021-pol2qm74 2848 67 ; ; : cord-015021-pol2qm74 2848 68 ll.uM ll.um ADD cord-015021-pol2qm74 2848 69 ionomycin ionomycin NNS cord-015021-pol2qm74 2848 70 ; ; : cord-015021-pol2qm74 2848 71 24 24 CD cord-015021-pol2qm74 2848 72 - - HYPH cord-015021-pol2qm74 2848 73 48h 48h CD cord-015021-pol2qm74 2848 74 ) ) -RRB- cord-015021-pol2qm74 2848 75 . . . cord-015021-pol2qm74 2849 1 The the DT cord-015021-pol2qm74 2849 2 actixdties actixdtie NNS cord-015021-pol2qm74 2849 3 of of IN cord-015021-pol2qm74 2849 4 BMMC BMMC NNP cord-015021-pol2qm74 2849 5 supernatants supernatant NNS cord-015021-pol2qm74 2849 6 were be VBD cord-015021-pol2qm74 2849 7 assessed assess VBN cord-015021-pol2qm74 2849 8 in in IN cord-015021-pol2qm74 2849 9 specific specific JJ cord-015021-pol2qm74 2849 10 biological biological JJ cord-015021-pol2qm74 2849 11 ( ( -LRB- cord-015021-pol2qm74 2849 12 IL-3 IL-3 NNP cord-015021-pol2qm74 2849 13 , , , cord-015021-pol2qm74 2849 14 IL-4 IL-4 NNP cord-015021-pol2qm74 2849 15 IL-6 IL-6 NNP cord-015021-pol2qm74 2849 16 , , , cord-015021-pol2qm74 2849 17 1L-9 1l-9 CD cord-015021-pol2qm74 2849 18 ) ) -RRB- cord-015021-pol2qm74 2850 1 and/or and/or CC cord-015021-pol2qm74 2851 1 ELISA ELISA NNP cord-015021-pol2qm74 2851 2 assays assay NNS cord-015021-pol2qm74 2851 3 ( ( -LRB- cord-015021-pol2qm74 2851 4 IL-5 IL-5 NNP cord-015021-pol2qm74 2851 5 , , , cord-015021-pol2qm74 2851 6 IL-9 IL-9 NNP cord-015021-pol2qm74 2851 7 ) ) -RRB- cord-015021-pol2qm74 2851 8 . . . cord-015021-pol2qm74 2852 1 Here here RB cord-015021-pol2qm74 2852 2 we -PRON- PRP cord-015021-pol2qm74 2852 3 show show VBP cord-015021-pol2qm74 2852 4 that that IN cord-015021-pol2qm74 2852 5 homogeneous homogeneous JJ cord-015021-pol2qm74 2852 6 populations population NNS cord-015021-pol2qm74 2852 7 of of IN cord-015021-pol2qm74 2852 8 BMMC BMMC NNP cord-015021-pol2qm74 2853 1 ( ( -LRB- cord-015021-pol2qm74 2853 2 > > NFP cord-015021-pol2qm74 2853 3 97%Alcian 97%alcian CD cord-015021-pol2qm74 2853 4 blue+/Safranln- blue+/Safranln- NNP cord-015021-pol2qm74 2853 5 ; ; : cord-015021-pol2qm74 2853 6 in in IN cord-015021-pol2qm74 2853 7 vitro vitro FW cord-015021-pol2qm74 2853 8 age age NN cord-015021-pol2qm74 2853 9 : : : cord-015021-pol2qm74 2853 10 4 4 CD cord-015021-pol2qm74 2853 11 weeks week NNS cord-015021-pol2qm74 2853 12 ) ) -RRB- cord-015021-pol2qm74 2853 13 generated generate VBN cord-015021-pol2qm74 2853 14 in in IN cord-015021-pol2qm74 2853 15 the the DT cord-015021-pol2qm74 2853 16 presence presence NN cord-015021-pol2qm74 2853 17 of of IN cord-015021-pol2qm74 2853 18 recombinant recombinant JJ cord-015021-pol2qm74 2853 19 ( ( -LRB- cord-015021-pol2qm74 2853 20 r r NN cord-015021-pol2qm74 2853 21 ) ) -RRB- cord-015021-pol2qm74 2853 22 raiL-3 rail-3 XX cord-015021-pol2qm74 2853 23 from from IN cord-015021-pol2qm74 2853 24 normal normal JJ cord-015021-pol2qm74 2853 25 BALB BALB NNP cord-015021-pol2qm74 2853 26 / / SYM cord-015021-pol2qm74 2853 27 c c NN cord-015021-pol2qm74 2853 28 mice mouse NNS cord-015021-pol2qm74 2853 29 produced produce VBD cord-015021-pol2qm74 2853 30 modest modest JJ cord-015021-pol2qm74 2853 31 amounts amount NNS cord-015021-pol2qm74 2853 32 of of IN cord-015021-pol2qm74 2853 33 1L-6 1l-6 CD cord-015021-pol2qm74 2853 34 and and CC cord-015021-pol2qm74 2853 35 low low JJ cord-015021-pol2qm74 2853 36 or or CC cord-015021-pol2qm74 2853 37 undetectable undetectable JJ cord-015021-pol2qm74 2853 38 levels level NNS cord-015021-pol2qm74 2853 39 of of IN cord-015021-pol2qm74 2853 40 IL-3 IL-3 NNP cord-015021-pol2qm74 2853 41 , , , cord-015021-pol2qm74 2853 42 -5 -5 NNP cord-015021-pol2qm74 2853 43 , , , cord-015021-pol2qm74 2853 44 and and CC cord-015021-pol2qm74 2853 45 -9 -9 NN cord-015021-pol2qm74 2853 46 after after IN cord-015021-pol2qm74 2853 47 induction induction NN cord-015021-pol2qm74 2853 48 with with IN cord-015021-pol2qm74 2853 49 lp lp NNP cord-015021-pol2qm74 2853 50 . . . cord-015021-pol2qm74 2854 1 M M NNP cord-015021-pol2qm74 2854 2 ionomycin ionomycin VBZ cord-015021-pol2qm74 2854 3 only only RB cord-015021-pol2qm74 2854 4 . . . cord-015021-pol2qm74 2855 1 However however RB cord-015021-pol2qm74 2855 2 , , , cord-015021-pol2qm74 2855 3 a a DT cord-015021-pol2qm74 2855 4 dramatic dramatic JJ cord-015021-pol2qm74 2855 5 increase increase NN cord-015021-pol2qm74 2855 6 ( ( -LRB- cord-015021-pol2qm74 2855 7 5-to 5-to CD cord-015021-pol2qm74 2855 8 10-fold 10-fold CD cord-015021-pol2qm74 2855 9 ) ) -RRB- cord-015021-pol2qm74 2855 10 of of IN cord-015021-pol2qm74 2855 11 these these DT cord-015021-pol2qm74 2855 12 cytokine cytokine NN cord-015021-pol2qm74 2855 13 activities activity NNS cord-015021-pol2qm74 2855 14 was be VBD cord-015021-pol2qm74 2855 15 noted note VBN cord-015021-pol2qm74 2855 16 , , , cord-015021-pol2qm74 2855 17 when when WRB cord-015021-pol2qm74 2855 18 in in IN cord-015021-pol2qm74 2855 19 addition addition NN cord-015021-pol2qm74 2855 20 to to IN cord-015021-pol2qm74 2855 21 ionomycin ionomycin NNP cord-015021-pol2qm74 2855 22 also also RB cord-015021-pol2qm74 2855 23 human human JJ cord-015021-pol2qm74 2855 24 ( ( -LRB- cord-015021-pol2qm74 2855 25 11 11 CD cord-015021-pol2qm74 2855 26 ) ) -RRB- cord-015021-pol2qm74 2855 27 rlL rlL NNS cord-015021-pol2qm74 2855 28 - - : cord-015021-pol2qm74 2855 29 la la NNP cord-015021-pol2qm74 2855 30 was be VBD cord-015021-pol2qm74 2855 31 provided provide VBN cord-015021-pol2qm74 2855 32 during during IN cord-015021-pol2qm74 2855 33 the the DT cord-015021-pol2qm74 2855 34 induction induction NN cord-015021-pol2qm74 2855 35 period period NN cord-015021-pol2qm74 2855 36 . . . cord-015021-pol2qm74 2856 1 This this DT cord-015021-pol2qm74 2856 2 IL-1 IL-1 NNP cord-015021-pol2qm74 2856 3 effect effect NN cord-015021-pol2qm74 2856 4 was be VBD cord-015021-pol2qm74 2856 5 dose dose JJ cord-015021-pol2qm74 2856 6 dependent dependent JJ cord-015021-pol2qm74 2856 7 with with IN cord-015021-pol2qm74 2856 8 a a DT cord-015021-pol2qm74 2856 9 maximgm maximgm NN cord-015021-pol2qm74 2856 10 at at IN cord-015021-pol2qm74 2856 11 2 2 CD cord-015021-pol2qm74 2856 12 - - SYM cord-015021-pol2qm74 2856 13 10 10 CD cord-015021-pol2qm74 2856 14 U U NNP cord-015021-pol2qm74 2856 15 / / SYM cord-015021-pol2qm74 2856 16 ml ml NNS cord-015021-pol2qm74 2856 17 hrlL hrlL NNP cord-015021-pol2qm74 2856 18 - - HYPH cord-015021-pol2qm74 2856 19 la la NN cord-015021-pol2qm74 2856 20 and and CC cord-015021-pol2qm74 2856 21 specific specific JJ cord-015021-pol2qm74 2856 22 , , , cord-015021-pol2qm74 2856 23 as as IN cord-015021-pol2qm74 2856 24 pre pre JJ cord-015021-pol2qm74 2856 25 - - NN cord-015021-pol2qm74 2856 26 incubation incubation JJ cord-015021-pol2qm74 2856 27 ( ( -LRB- cord-015021-pol2qm74 2856 28 lh lh NNP cord-015021-pol2qm74 2856 29 ) ) -RRB- cord-015021-pol2qm74 2856 30 of of IN cord-015021-pol2qm74 2856 31 BMMC BMMC NNP cord-015021-pol2qm74 2857 1 with with IN cord-015021-pol2qm74 2857 2 20 20 CD cord-015021-pol2qm74 2857 3 ng ng NN cord-015021-pol2qm74 2857 4 / / SYM cord-015021-pol2qm74 2857 5 ml ml NN cord-015021-pol2qm74 2858 1 hrlL-1 hrlL-1 NNP cord-015021-pol2qm74 2858 2 receptor receptor NN cord-015021-pol2qm74 2858 3 antagonist antagonist NN cord-015021-pol2qm74 2858 4 abolished abolish VBD cord-015021-pol2qm74 2858 5 the the DT cord-015021-pol2qm74 2858 6 action action NN cord-015021-pol2qm74 2858 7 of of IN cord-015021-pol2qm74 2858 8 2 2 CD cord-015021-pol2qm74 2858 9 U U NNP cord-015021-pol2qm74 2858 10 / / SYM cord-015021-pol2qm74 2858 11 ml ml IN cord-015021-pol2qm74 2858 12 hrlL hrlL NNP cord-015021-pol2qm74 2858 13 - - HYPH cord-015021-pol2qm74 2858 14 lcc lcc NNP cord-015021-pol2qm74 2858 15 Similar similar JJ cord-015021-pol2qm74 2858 16 effects effect NNS cord-015021-pol2qm74 2858 17 were be VBD cord-015021-pol2qm74 2858 18 noted note VBN cord-015021-pol2qm74 2858 19 with with IN cord-015021-pol2qm74 2858 20 hrlL hrlL NNS cord-015021-pol2qm74 2858 21 - - HYPH cord-015021-pol2qm74 2858 22 lg lg NN cord-015021-pol2qm74 2858 23 or or CC cord-015021-pol2qm74 2858 24 rurlL rurlL NNP cord-015021-pol2qm74 2858 25 - - HYPH cord-015021-pol2qm74 2858 26 lB lb NN cord-015021-pol2qm74 2859 1 ( ( -LRB- cord-015021-pol2qm74 2859 2 lng lng NNP cord-015021-pol2qm74 2859 3 / / SYM cord-015021-pol2qm74 2859 4 ml ml NNP cord-015021-pol2qm74 2859 5 , , , cord-015021-pol2qm74 2859 6 respectively respectively RB cord-015021-pol2qm74 2859 7 ) ) -RRB- cord-015021-pol2qm74 2859 8 , , , cord-015021-pol2qm74 2859 9 but but CC cord-015021-pol2qm74 2859 10 not not RB cord-015021-pol2qm74 2859 11 with with IN cord-015021-pol2qm74 2859 12 rhlL-6 rhll-6 CD cord-015021-pol2qm74 2859 13 or or CC cord-015021-pol2qm74 2859 14 rmTNF-~. rmtnf-~. NN cord-015021-pol2qm74 2860 1 Both both DT cord-015021-pol2qm74 2860 2 mrlL-10 mrlL-10 NNP cord-015021-pol2qm74 2860 3 and and CC cord-015021-pol2qm74 2860 4 hrlL-10 hrlL-10 NNP cord-015021-pol2qm74 2860 5 substantially substantially RB cord-015021-pol2qm74 2860 6 enhanced enhance VBN cord-015021-pol2qm74 2860 7 ionomycin ionomycin NN cord-015021-pol2qm74 2860 8 - - HYPH cord-015021-pol2qm74 2860 9 induced induce VBN cord-015021-pol2qm74 2860 10 1L-6 1l-6 CD cord-015021-pol2qm74 2860 11 production production NN cord-015021-pol2qm74 2860 12 of of IN cord-015021-pol2qm74 2860 13 BMMC BMMC NNP cord-015021-pol2qm74 2860 14 in in IN cord-015021-pol2qm74 2860 15 the the DT cord-015021-pol2qm74 2860 16 absence absence NN cord-015021-pol2qm74 2860 17 or or CC cord-015021-pol2qm74 2860 18 presence presence NN cord-015021-pol2qm74 2860 19 of of IN cord-015021-pol2qm74 2860 20 IL-1 IL-1 NNP cord-015021-pol2qm74 2860 21 . . . cord-015021-pol2qm74 2860 22 IL-10 IL-10 NNP cord-015021-pol2qm74 2860 23 significantly significantly RB cord-015021-pol2qm74 2860 24 enhanced enhance VBD cord-015021-pol2qm74 2860 25 IL-6 IL-6 NNP cord-015021-pol2qm74 2860 26 and and CC cord-015021-pol2qm74 2860 27 IL-9 IL-9 NNP cord-015021-pol2qm74 2860 28 production production NN cord-015021-pol2qm74 2860 29 while while IN cord-015021-pol2qm74 2860 30 decreasing decrease VBG cord-015021-pol2qm74 2860 31 IL-3 IL-3 NNP cord-015021-pol2qm74 2860 32 activities activity NNS cord-015021-pol2qm74 2860 33 to to TO cord-015021-pol2qm74 2860 34 abont abont VB cord-015021-pol2qm74 2860 35 50 50 CD cord-015021-pol2qm74 2860 36 - - SYM cord-015021-pol2qm74 2860 37 90 90 CD cord-015021-pol2qm74 2860 38 % % NN cord-015021-pol2qm74 2860 39 of of IN cord-015021-pol2qm74 2860 40 control control NN cord-015021-pol2qm74 2860 41 levels level NNS cord-015021-pol2qm74 2860 42 , , , cord-015021-pol2qm74 2860 43 when when WRB cord-015021-pol2qm74 2860 44 IL IL NNP cord-015021-pol2qm74 2860 45 - - HYPH cord-015021-pol2qm74 2860 46 I0 I0 NNP cord-015021-pol2qm74 2860 47 was be VBD cord-015021-pol2qm74 2860 48 provided provide VBN cord-015021-pol2qm74 2860 49 in in IN cord-015021-pol2qm74 2860 50 the the DT cord-015021-pol2qm74 2860 51 presence presence NN cord-015021-pol2qm74 2860 52 of of IN cord-015021-pol2qm74 2860 53 IL IL NNP cord-015021-pol2qm74 2860 54 - - HYPH cord-015021-pol2qm74 2860 55 l l NNP cord-015021-pol2qm74 2860 56 / / SYM cord-015021-pol2qm74 2860 57 ionomycin ionomycin NNS cord-015021-pol2qm74 2860 58 . . . cord-015021-pol2qm74 2861 1 A a DT cord-015021-pol2qm74 2861 2 monoclonal monoclonal JJ cord-015021-pol2qm74 2861 3 anti anti JJ cord-015021-pol2qm74 2861 4 - - JJ cord-015021-pol2qm74 2861 5 nfiL nfil JJ cord-015021-pol2qm74 2861 6 - - HYPH cord-015021-pol2qm74 2861 7 t0 t0 NNP cord-015021-pol2qm74 2861 8 antibody antibody NN cord-015021-pol2qm74 2861 9 ( ( -LRB- cord-015021-pol2qm74 2861 10 ascites ascite NNS cord-015021-pol2qm74 2861 11 1:200 1:200 CD cord-015021-pol2qm74 2861 12 ) ) -RRB- cord-015021-pol2qm74 2861 13 abrogated abrogate VBD cord-015021-pol2qm74 2861 14 the the DT cord-015021-pol2qm74 2861 15 effects effect NNS cord-015021-pol2qm74 2861 16 of of IN cord-015021-pol2qm74 2861 17 mrlL-10 mrlL-10 NNP cord-015021-pol2qm74 2861 18 . . . cord-015021-pol2qm74 2862 1 Other other JJ cord-015021-pol2qm74 2862 2 mast mast JJ cord-015021-pol2qm74 2862 3 cell cell NN cord-015021-pol2qm74 2862 4 - - HYPH cord-015021-pol2qm74 2862 5 active active JJ cord-015021-pol2qm74 2862 6 cy cy NNP cord-015021-pol2qm74 2862 7 ~ ~ CD cord-015021-pol2qm74 2862 8 okines okines NNP cord-015021-pol2qm74 2862 9 ( ( -LRB- cord-015021-pol2qm74 2862 10 ] ] -RRB- cord-015021-pol2qm74 2862 11 1,-3 1,-3 NNP cord-015021-pol2qm74 2862 12 , , , cord-015021-pol2qm74 2862 13 IL-4 IL-4 NNP cord-015021-pol2qm74 2862 14 , , , cord-015021-pol2qm74 2862 15 1L-9 1l-9 CD cord-015021-pol2qm74 2862 16 , , , cord-015021-pol2qm74 2862 17 NGF NGF NNP cord-015021-pol2qm74 2862 18 , , , cord-015021-pol2qm74 2862 19 or or CC cord-015021-pol2qm74 2862 20 KL KL NNP cord-015021-pol2qm74 2862 21 ) ) -RRB- cord-015021-pol2qm74 2862 22 added add VBD cord-015021-pol2qm74 2862 23 to to IN cord-015021-pol2qm74 2862 24 ionomycia ionomycia NNP cord-015021-pol2qm74 2862 25 - - , cord-015021-pol2qm74 2862 26 or or CC cord-015021-pol2qm74 2862 27 1L-1 1l-1 CD cord-015021-pol2qm74 2862 28 / / SYM cord-015021-pol2qm74 2862 29 ionomycin ionomycin NNS cord-015021-pol2qm74 2862 30 - - HYPH cord-015021-pol2qm74 2862 31 treated treat VBN cord-015021-pol2qm74 2862 32 BMMC BMMC NNP cord-015021-pol2qm74 2862 33 had have VBD cord-015021-pol2qm74 2862 34 no no DT cord-015021-pol2qm74 2862 35 major major JJ cord-015021-pol2qm74 2862 36 effects effect NNS cord-015021-pol2qm74 2862 37 on on IN cord-015021-pol2qm74 2862 38 cytokine cytokine NN cord-015021-pol2qm74 2862 39 production production NN cord-015021-pol2qm74 2862 40 . . . cord-015021-pol2qm74 2863 1 IL-1 IL-1 NNP cord-015021-pol2qm74 2863 2 and and CC cord-015021-pol2qm74 2863 3 IL IL NNP cord-015021-pol2qm74 2863 4 - - HYPH cord-015021-pol2qm74 2863 5 I0 I0 NNP cord-015021-pol2qm74 2863 6 did do VBD cord-015021-pol2qm74 2863 7 not not RB cord-015021-pol2qm74 2863 8 induce induce VB cord-015021-pol2qm74 2863 9 significant significant JJ cord-015021-pol2qm74 2863 10 cytokine cytokine NN cord-015021-pol2qm74 2863 11 release release NN cord-015021-pol2qm74 2863 12 in in IN cord-015021-pol2qm74 2863 13 the the DT cord-015021-pol2qm74 2863 14 absence absence NN cord-015021-pol2qm74 2863 15 of of IN cord-015021-pol2qm74 2863 16 ionomycin ionomycin NNS cord-015021-pol2qm74 2863 17 suggesting suggest VBG cord-015021-pol2qm74 2863 18 tlmt tlmt IN cord-015021-pol2qm74 2863 19 Cadependent Cadependent NNP cord-015021-pol2qm74 2863 20 signalling signalling NN cord-015021-pol2qm74 2863 21 was be VBD cord-015021-pol2qm74 2863 22 required require VBN cord-015021-pol2qm74 2863 23 . . . cord-015021-pol2qm74 2864 1 At at IN cord-015021-pol2qm74 2864 2 doses dose NNS cord-015021-pol2qm74 2864 3 of of IN cord-015021-pol2qm74 2864 4 10"6 10"6 CD cord-015021-pol2qm74 2864 5 M M NNP cord-015021-pol2qm74 2864 6 , , , cord-015021-pol2qm74 2864 7 dexamethasone dexamethasone NN cord-015021-pol2qm74 2864 8 , , , cord-015021-pol2qm74 2864 9 corticosterone corticosterone NN cord-015021-pol2qm74 2864 10 , , , cord-015021-pol2qm74 2864 11 or or CC cord-015021-pol2qm74 2864 12 hydrocortisone hydrocortisone NN cord-015021-pol2qm74 2864 13 almost almost RB cord-015021-pol2qm74 2864 14 completely completely RB cord-015021-pol2qm74 2864 15 abolished abolish VBN cord-015021-pol2qm74 2864 16 ionomycin ionomycin NNS cord-015021-pol2qm74 2864 17 / / SYM cord-015021-pol2qm74 2864 18 IL-1 IL-1 NNP cord-015021-pol2qm74 2864 19 / / SYM cord-015021-pol2qm74 2864 20 lL-10induced ll-10induced CD cord-015021-pol2qm74 2864 21 cytokine cytokine NN cord-015021-pol2qm74 2864 22 production production NN cord-015021-pol2qm74 2864 23 . . . cord-015021-pol2qm74 2865 1 The the DT cord-015021-pol2qm74 2865 2 inducer inducer NN cord-015021-pol2qm74 2865 3 cocktails cocktail NNS cord-015021-pol2qm74 2865 4 per per FW cord-015021-pol2qm74 2865 5 se se FW cord-015021-pol2qm74 2865 6 did do VBD cord-015021-pol2qm74 2865 7 not not RB cord-015021-pol2qm74 2865 8 interfere interfere VB cord-015021-pol2qm74 2865 9 with with IN cord-015021-pol2qm74 2865 10 the the DT cord-015021-pol2qm74 2865 11 cytokine cytokine NN cord-015021-pol2qm74 2865 12 bio bio NN cord-015021-pol2qm74 2865 13 - - HYPH cord-015021-pol2qm74 2865 14 assays assay NNS cord-015021-pol2qm74 2865 15 . . . cord-015021-pol2qm74 2866 1 In in IN cord-015021-pol2qm74 2866 2 case case NN cord-015021-pol2qm74 2866 3 of of IN cord-015021-pol2qm74 2866 4 IL-9 IL-9 NNP cord-015021-pol2qm74 2866 5 inducibility inducibility NN cord-015021-pol2qm74 2866 6 of of IN cord-015021-pol2qm74 2866 7 this this DT cord-015021-pol2qm74 2866 8 cytokine cytokine NN cord-015021-pol2qm74 2866 9 in in IN cord-015021-pol2qm74 2866 10 BMMC BMMC NNP cord-015021-pol2qm74 2866 11 was be VBD cord-015021-pol2qm74 2866 12 confirmed confirm VBN cord-015021-pol2qm74 2866 13 at at IN cord-015021-pol2qm74 2866 14 the the DT cord-015021-pol2qm74 2866 15 mRNA mRNA NNP cord-015021-pol2qm74 2866 16 level level NN cord-015021-pol2qm74 2866 17 by by IN cord-015021-pol2qm74 2866 18 Northern northern JJ cord-015021-pol2qm74 2866 19 blot blot NN cord-015021-pol2qm74 2866 20 analysis analysis NN cord-015021-pol2qm74 2866 21 . . . cord-015021-pol2qm74 2867 1 Hence hence RB cord-015021-pol2qm74 2867 2 our -PRON- PRP$ cord-015021-pol2qm74 2867 3 data datum NNS cord-015021-pol2qm74 2867 4 show show VBP cord-015021-pol2qm74 2867 5 that that IN cord-015021-pol2qm74 2867 6 activated activate VBN cord-015021-pol2qm74 2867 7 mast mast NN cord-015021-pol2qm74 2867 8 cells cell NNS cord-015021-pol2qm74 2867 9 are be VBP cord-015021-pol2qm74 2867 10 a a DT cord-015021-pol2qm74 2867 11 source source NN cord-015021-pol2qm74 2867 12 of of IN cord-015021-pol2qm74 2867 13 IL-9 IL-9 NNP cord-015021-pol2qm74 2867 14 previously previously RB cord-015021-pol2qm74 2867 15 recognized recognize VBD cord-015021-pol2qm74 2867 16 as as IN cord-015021-pol2qm74 2867 17 a a DT cord-015021-pol2qm74 2867 18 product product NN cord-015021-pol2qm74 2867 19 of of IN cord-015021-pol2qm74 2867 20 TH2type TH2type NNP cord-015021-pol2qm74 2867 21 lymphocytes lymphocyte NNS cord-015021-pol2qm74 2867 22 only only RB cord-015021-pol2qm74 2867 23 . . . cord-015021-pol2qm74 2868 1 Moreover moreover RB cord-015021-pol2qm74 2868 2 , , , cord-015021-pol2qm74 2868 3 our -PRON- PRP$ cord-015021-pol2qm74 2868 4 study study NN cord-015021-pol2qm74 2868 5 reveals reveal VBZ cord-015021-pol2qm74 2868 6 novel novel JJ cord-015021-pol2qm74 2868 7 functional functional JJ cord-015021-pol2qm74 2868 8 roles role NNS cord-015021-pol2qm74 2868 9 for for IN cord-015021-pol2qm74 2868 10 I I NNP cord-015021-pol2qm74 2868 11 - - HYPH cord-015021-pol2qm74 2868 12 L l NN cord-015021-pol2qm74 2868 13 - - : cord-015021-pol2qm74 2868 14 I I NNP cord-015021-pol2qm74 2868 15 , , , cord-015021-pol2qm74 2868 16 IL-10 IL-10 NNP cord-015021-pol2qm74 2868 17 , , , cord-015021-pol2qm74 2868 18 and and CC cord-015021-pol2qm74 2868 19 ghicecorticoids ghicecorticoid NNS cord-015021-pol2qm74 2868 20 in in IN cord-015021-pol2qm74 2868 21 the the DT cord-015021-pol2qm74 2868 22 regulation regulation NN cord-015021-pol2qm74 2868 23 of of IN cord-015021-pol2qm74 2868 24 cytoldne cytoldne NNP cord-015021-pol2qm74 2868 25 production production NN cord-015021-pol2qm74 2868 26 in in IN cord-015021-pol2qm74 2868 27 mast mast JJ cord-015021-pol2qm74 2868 28 ceils ceil NNS cord-015021-pol2qm74 2868 29 . . . cord-015021-pol2qm74 2869 1 Accumulating accumulate VBG cord-015021-pol2qm74 2869 2 data datum NNS cord-015021-pol2qm74 2869 3 suggests suggest VBZ cord-015021-pol2qm74 2869 4 that that IN cord-015021-pol2qm74 2869 5 cytokines cytokine NNS cord-015021-pol2qm74 2869 6 , , , cord-015021-pol2qm74 2869 7 peptides peptide NNS cord-015021-pol2qm74 2869 8 involved involve VBN cord-015021-pol2qm74 2869 9 in in IN cord-015021-pol2qm74 2869 10 regulation regulation NN cord-015021-pol2qm74 2869 11 of of IN cord-015021-pol2qm74 2869 12 both both DT cord-015021-pol2qm74 2869 13 physiological physiological JJ cord-015021-pol2qm74 2869 14 and and CC cord-015021-pol2qm74 2869 15 pathological pathological JJ cord-015021-pol2qm74 2869 16 immunological immunological JJ cord-015021-pol2qm74 2869 17 responses response NNS cord-015021-pol2qm74 2869 18 , , , cord-015021-pol2qm74 2869 19 predominantly predominantly RB cord-015021-pol2qm74 2869 20 are be VBP cord-015021-pol2qm74 2869 21 produced produce VBN cord-015021-pol2qm74 2869 22 at at IN cord-015021-pol2qm74 2869 23 the the DT cord-015021-pol2qm74 2869 24 local local JJ cord-015021-pol2qm74 2869 25 site site NN cord-015021-pol2qm74 2869 26 of of IN cord-015021-pol2qm74 2869 27 antigen antigen NN cord-015021-pol2qm74 2869 28 stimulation stimulation NN cord-015021-pol2qm74 2869 29 . . . cord-015021-pol2qm74 2870 1 A a DT cord-015021-pol2qm74 2870 2 new new JJ cord-015021-pol2qm74 2870 3 method method NN cord-015021-pol2qm74 2870 4 was be VBD cord-015021-pol2qm74 2870 5 used use VBN cord-015021-pol2qm74 2870 6 to to TO cord-015021-pol2qm74 2870 7 detect detect VB cord-015021-pol2qm74 2870 8 cytokine cytokine NN cord-015021-pol2qm74 2870 9 - - HYPH cord-015021-pol2qm74 2870 10 producing produce VBG cord-015021-pol2qm74 2870 11 cells cell NNS cord-015021-pol2qm74 2870 12 in in IN cord-015021-pol2qm74 2870 13 haman haman NNP cord-015021-pol2qm74 2870 14 tissue tissue NN cord-015021-pol2qm74 2870 15 at at IN cord-015021-pol2qm74 2870 16 the the DT cord-015021-pol2qm74 2870 17 protein protein NN cord-015021-pol2qm74 2870 18 level level NN cord-015021-pol2qm74 2870 19 . . . cord-015021-pol2qm74 2871 1 Single single JJ cord-015021-pol2qm74 2871 2 - - HYPH cord-015021-pol2qm74 2871 3 cell cell NN cord-015021-pol2qm74 2871 4 production production NN cord-015021-pol2qm74 2871 5 of of IN cord-015021-pol2qm74 2871 6 17 17 CD cord-015021-pol2qm74 2871 7 different different JJ cord-015021-pol2qm74 2871 8 httman httman NN cord-015021-pol2qm74 2871 9 cytokines cytokine NNS cord-015021-pol2qm74 2871 10 , , , cord-015021-pol2qm74 2871 11 ILia ILia NNP cord-015021-pol2qm74 2871 12 , , , cord-015021-pol2qm74 2871 13 ILl ILl NNP cord-015021-pol2qm74 2871 14 [ [ -LRB- cord-015021-pol2qm74 2871 15 3 3 CD cord-015021-pol2qm74 2871 16 , , , cord-015021-pol2qm74 2871 17 ILlra ILlra NNP cord-015021-pol2qm74 2871 18 , , , cord-015021-pol2qm74 2871 19 IL2 IL2 NNP cord-015021-pol2qm74 2871 20 , , , cord-015021-pol2qm74 2871 21 IL3 IL3 NNP cord-015021-pol2qm74 2871 22 , , , cord-015021-pol2qm74 2871 23 IL4 IL4 NNP cord-015021-pol2qm74 2871 24 , , , cord-015021-pol2qm74 2871 25 IL5 IL5 NNP cord-015021-pol2qm74 2871 26 , , , cord-015021-pol2qm74 2871 27 IL6 IL6 NNP cord-015021-pol2qm74 2871 28 , , , cord-015021-pol2qm74 2871 29 ILS ILS NNP cord-015021-pol2qm74 2871 30 , , , cord-015021-pol2qm74 2871 31 ILl0 ILl0 NNP cord-015021-pol2qm74 2871 32 , , , cord-015021-pol2qm74 2871 33 GM GM NNP cord-015021-pol2qm74 2871 34 - - HYPH cord-015021-pol2qm74 2871 35 CSF CSF NNP cord-015021-pol2qm74 2871 36 , , , cord-015021-pol2qm74 2871 37 TNFa TNFa NNP cord-015021-pol2qm74 2871 38 , , , cord-015021-pol2qm74 2871 39 IFN IFN NNP cord-015021-pol2qm74 2871 40 7 7 CD cord-015021-pol2qm74 2871 41 and and CC cord-015021-pol2qm74 2871 42 TGF[31.3 TGF[31.3 NNP cord-015021-pol2qm74 2871 43 , , , cord-015021-pol2qm74 2871 44 was be VBD cord-015021-pol2qm74 2871 45 identified identify VBN cord-015021-pol2qm74 2871 46 by by IN cord-015021-pol2qm74 2871 47 indirect indirect JJ cord-015021-pol2qm74 2871 48 immunohistochemical immunohistochemical JJ cord-015021-pol2qm74 2871 49 staining stain VBG cord-015021-pol2qm74 2871 50 procedures procedure NNS cord-015021-pol2qm74 2871 51 and and CC cord-015021-pol2qm74 2871 52 use use NN cord-015021-pol2qm74 2871 53 of of IN cord-015021-pol2qm74 2871 54 carefully carefully RB cord-015021-pol2qm74 2871 55 selected select VBN cord-015021-pol2qm74 2871 56 cytokine cytokine JJ cord-015021-pol2qm74 2871 57 - - HYPH cord-015021-pol2qm74 2871 58 specific specific JJ cord-015021-pol2qm74 2871 59 mAb mab NN cord-015021-pol2qm74 2871 60 's 's POS cord-015021-pol2qm74 2871 61 . . . cord-015021-pol2qm74 2872 1 Frozen frozen JJ cord-015021-pol2qm74 2872 2 sections section NNS cord-015021-pol2qm74 2872 3 were be VBD cord-015021-pol2qm74 2872 4 fixed fix VBN cord-015021-pol2qm74 2872 5 with with IN cord-015021-pol2qm74 2872 6 4 4 CD cord-015021-pol2qm74 2872 7 % % NN cord-015021-pol2qm74 2872 8 paraformaldehyde paraformaldehyde JJ cord-015021-pol2qm74 2872 9 and and CC cord-015021-pol2qm74 2872 10 permeabilized permeabilize VBN cord-015021-pol2qm74 2872 11 by by IN cord-015021-pol2qm74 2872 12 0.1 0.1 CD cord-015021-pol2qm74 2872 13 % % NN cord-015021-pol2qm74 2872 14 saponin saponin NN cord-015021-pol2qm74 2872 15 treatment treatment NN cord-015021-pol2qm74 2872 16 , , , cord-015021-pol2qm74 2872 17 eluting elute VBG cord-015021-pol2qm74 2872 18 cholesterol cholesterol NN cord-015021-pol2qm74 2872 19 from from IN cord-015021-pol2qm74 2872 20 the the DT cord-015021-pol2qm74 2872 21 membranes membrane NNS cord-015021-pol2qm74 2872 22 . . . cord-015021-pol2qm74 2873 1 The the DT cord-015021-pol2qm74 2873 2 intracellular intracellular JJ cord-015021-pol2qm74 2873 3 presence presence NN cord-015021-pol2qm74 2873 4 of of IN cord-015021-pol2qm74 2873 5 all all DT cord-015021-pol2qm74 2873 6 cytokines cytokine NNS cord-015021-pol2qm74 2873 7 except except IN cord-015021-pol2qm74 2873 8 ILl ILl NNP cord-015021-pol2qm74 2873 9 , , , cord-015021-pol2qm74 2873 10 ILlra ILlra NNP cord-015021-pol2qm74 2873 11 ( ( -LRB- cord-015021-pol2qm74 2873 12 late late JJ cord-015021-pol2qm74 2873 13 ) ) -RRB- cord-015021-pol2qm74 2873 14 and and CC cord-015021-pol2qm74 2873 15 TFG[31_3 TFG[31_3 NNP cord-015021-pol2qm74 2873 16 , , , cord-015021-pol2qm74 2873 17 could could MD cord-015021-pol2qm74 2873 18 be be VB cord-015021-pol2qm74 2873 19 demonstrated demonstrate VBN cord-015021-pol2qm74 2873 20 by by IN cord-015021-pol2qm74 2873 21 a a DT cord-015021-pol2qm74 2873 22 characteristic characteristic JJ cord-015021-pol2qm74 2873 23 perinuclear perinuclear NN cord-015021-pol2qm74 2873 24 configuration configuration NN cord-015021-pol2qm74 2873 25 in in IN cord-015021-pol2qm74 2873 26 producer producer NN cord-015021-pol2qm74 2873 27 cells cell NNS cord-015021-pol2qm74 2873 28 . . . cord-015021-pol2qm74 2874 1 In in IN cord-015021-pol2qm74 2874 2 addition addition NN cord-015021-pol2qm74 2874 3 , , , cord-015021-pol2qm74 2874 4 the the DT cord-015021-pol2qm74 2874 5 immunoreactivity immunoreactivity NN cord-015021-pol2qm74 2874 6 extended extend VBD cord-015021-pol2qm74 2874 7 over over IN cord-015021-pol2qm74 2874 8 a a DT cord-015021-pol2qm74 2874 9 large large JJ cord-015021-pol2qm74 2874 10 extracellular extracellular JJ cord-015021-pol2qm74 2874 11 area area NN cord-015021-pol2qm74 2874 12 encompassing encompass VBG cord-015021-pol2qm74 2874 13 the the DT cord-015021-pol2qm74 2874 14 producer producer NN cord-015021-pol2qm74 2874 15 cell cell NN cord-015021-pol2qm74 2874 16 . . . cord-015021-pol2qm74 2875 1 A a DT cord-015021-pol2qm74 2875 2 localization localization NN cord-015021-pol2qm74 2875 3 of of IN cord-015021-pol2qm74 2875 4 the the DT cord-015021-pol2qm74 2875 5 cytokine cytokine NN cord-015021-pol2qm74 2875 6 to to IN cord-015021-pol2qm74 2875 7 the the DT cord-015021-pol2qm74 2875 8 Golgi Golgi NNP cord-015021-pol2qm74 2875 9 - - HYPH cord-015021-pol2qm74 2875 10 organelle organelle NN cord-015021-pol2qm74 2875 11 was be VBD cord-015021-pol2qm74 2875 12 established establish VBN cord-015021-pol2qm74 2875 13 by by IN cord-015021-pol2qm74 2875 14 use use NN cord-015021-pol2qm74 2875 15 of of IN cord-015021-pol2qm74 2875 16 two two CD cord-015021-pol2qm74 2875 17 culour culour NN cord-015021-pol2qm74 2875 18 staining stain VBG cord-015021-pol2qm74 2875 19 including include VBG cord-015021-pol2qm74 2875 20 a a DT cord-015021-pol2qm74 2875 21 haman haman NNP cord-015021-pol2qm74 2875 22 Golgi Golgi NNP cord-015021-pol2qm74 2875 23 complex complex JJ cord-015021-pol2qm74 2875 24 specific specific JJ cord-015021-pol2qm74 2875 25 mAb mab NN cord-015021-pol2qm74 2875 26 . . . cord-015021-pol2qm74 2876 1 This this DT cord-015021-pol2qm74 2876 2 staining staining NN cord-015021-pol2qm74 2876 3 pattern pattern NN cord-015021-pol2qm74 2876 4 was be VBD cord-015021-pol2qm74 2876 5 only only RB cord-015021-pol2qm74 2876 6 evident evident JJ cord-015021-pol2qm74 2876 7 in in IN cord-015021-pol2qm74 2876 8 producer producer NN cord-015021-pol2qm74 2876 9 cells cell NNS cord-015021-pol2qm74 2876 10 because because IN cord-015021-pol2qm74 2876 11 injection injection NN cord-015021-pol2qm74 2876 12 of of IN cord-015021-pol2qm74 2876 13 recombinant recombinant JJ cord-015021-pol2qm74 2876 14 human human JJ cord-015021-pol2qm74 2876 15 cytgkines cytgkine NNS cord-015021-pol2qm74 2876 16 into into IN cord-015021-pol2qm74 2876 17 the the DT cord-015021-pol2qm74 2876 18 tissue tissue NN cord-015021-pol2qm74 2876 19 caused cause VBD cord-015021-pol2qm74 2876 20 a a DT cord-015021-pol2qm74 2876 21 membraneous membraneous JJ cord-015021-pol2qm74 2876 22 and and CC cord-015021-pol2qm74 2876 23 extracellular extracellular JJ cord-015021-pol2qm74 2876 24 staining staining NN cord-015021-pol2qm74 2876 25 pattern pattern NN cord-015021-pol2qm74 2876 26 . . . cord-015021-pol2qm74 2877 1 Both both DT cord-015021-pol2qm74 2877 2 the the DT cord-015021-pol2qm74 2877 3 extra extra JJ cord-015021-pol2qm74 2877 4 - - : cord-015021-pol2qm74 2877 5 and and CC cord-015021-pol2qm74 2877 6 the the DT cord-015021-pol2qm74 2877 7 intracellular intracellular JJ cord-015021-pol2qm74 2877 8 types type NNS cord-015021-pol2qm74 2877 9 of of IN cord-015021-pol2qm74 2877 10 staining stain VBG cord-015021-pol2qm74 2877 11 reaction reaction NN cord-015021-pol2qm74 2877 12 could could MD cord-015021-pol2qm74 2877 13 , , , cord-015021-pol2qm74 2877 14 however however RB cord-015021-pol2qm74 2877 15 , , , cord-015021-pol2qm74 2877 16 be be VB cord-015021-pol2qm74 2877 17 blocked block VBN cord-015021-pol2qm74 2877 18 by by IN cord-015021-pol2qm74 2877 19 preincubating preincubate VBG cord-015021-pol2qm74 2877 20 the the DT cord-015021-pol2qm74 2877 21 cytokine cytokine JJ cord-015021-pol2qm74 2877 22 specific specific JJ cord-015021-pol2qm74 2877 23 mAb mab NN cord-015021-pol2qm74 2877 24 with with IN cord-015021-pol2qm74 2877 25 pure pure JJ cord-015021-pol2qm74 2877 26 human human JJ cord-015021-pol2qm74 2877 27 interleukins interleukin NNS cord-015021-pol2qm74 2877 28 . . . cord-015021-pol2qm74 2878 1 Oxygen oxygen NN cord-015021-pol2qm74 2878 2 radicals radical NNS cord-015021-pol2qm74 2878 3 ( ( -LRB- cord-015021-pol2qm74 2878 4 OR or CC cord-015021-pol2qm74 2878 5 ) ) -RRB- cord-015021-pol2qm74 2878 6 directly directly RB cord-015021-pol2qm74 2878 7 induce induce VB cord-015021-pol2qm74 2878 8 lipid lipid NN cord-015021-pol2qm74 2878 9 peroxidation peroxidation NN cord-015021-pol2qm74 2878 10 , , , cord-015021-pol2qm74 2878 11 indirectly indirectly RB cord-015021-pol2qm74 2878 12 they -PRON- PRP cord-015021-pol2qm74 2878 13 trigger trigger VBP cord-015021-pol2qm74 2878 14 adhesion adhesion NN cord-015021-pol2qm74 2878 15 and and CC cord-015021-pol2qm74 2878 16 activation activation NN cord-015021-pol2qm74 2878 17 of of IN cord-015021-pol2qm74 2878 18 PMN PMN NNP cord-015021-pol2qm74 2878 19 leukocytes leukocyte NNS cord-015021-pol2qm74 2878 20 . . . cord-015021-pol2qm74 2879 1 We -PRON- PRP cord-015021-pol2qm74 2879 2 investigated investigate VBD cord-015021-pol2qm74 2879 3 whether whether IN cord-015021-pol2qm74 2879 4 OR or CC cord-015021-pol2qm74 2879 5 also also RB cord-015021-pol2qm74 2879 6 lead lead VB cord-015021-pol2qm74 2879 7 to to IN cord-015021-pol2qm74 2879 8 a a DT cord-015021-pol2qm74 2879 9 release release NN cord-015021-pol2qm74 2879 10 of of IN cord-015021-pol2qm74 2879 11 acute acute JJ cord-015021-pol2qm74 2879 12 - - HYPH cord-015021-pol2qm74 2879 13 phase phase NN cord-015021-pol2qm74 2879 14 response response NN cord-015021-pol2qm74 2879 15 cytokins cytokin NNS cord-015021-pol2qm74 2879 16 such such JJ cord-015021-pol2qm74 2879 17 as as IN cord-015021-pol2qm74 2879 18 TNF tnf NN cord-015021-pol2qm74 2879 19 - - HYPH cord-015021-pol2qm74 2879 20 alpha alpha NN cord-015021-pol2qm74 2879 21 , , , cord-015021-pol2qm74 2879 22 IL IL NNP cord-015021-pol2qm74 2879 23 - - : cord-015021-pol2qm74 2879 24 I I NNP cord-015021-pol2qm74 2879 25 beta beta NN cord-015021-pol2qm74 2879 26 or or CC cord-015021-pol2qm74 2880 1 IL-6 IL-6 NNP cord-015021-pol2qm74 2880 2 in in IN cord-015021-pol2qm74 2880 3 whole whole JJ cord-015021-pol2qm74 2880 4 blood blood NN cord-015021-pol2qm74 2880 5 cultures culture NNS cord-015021-pol2qm74 2880 6 to to TO cord-015021-pol2qm74 2880 7 maintain maintain VB cord-015021-pol2qm74 2880 8 the the DT cord-015021-pol2qm74 2880 9 induced induce VBN cord-015021-pol2qm74 2880 10 inflammatory inflammatory JJ cord-015021-pol2qm74 2880 11 reaction reaction NN cord-015021-pol2qm74 2880 12 . . . cord-015021-pol2qm74 2881 1 Methods method NNS cord-015021-pol2qm74 2881 2 : : : cord-015021-pol2qm74 2881 3 Blood blood NN cord-015021-pol2qm74 2881 4 samples sample NNS cord-015021-pol2qm74 2881 5 from from IN cord-015021-pol2qm74 2881 6 healthy healthy JJ cord-015021-pol2qm74 2881 7 volunteers volunteer NNS cord-015021-pol2qm74 2881 8 ( ( -LRB- cord-015021-pol2qm74 2881 9 n=10 n=10 NNP cord-015021-pol2qm74 2881 10 ) ) -RRB- cord-015021-pol2qm74 2881 11 were be VBD cord-015021-pol2qm74 2881 12 incubated incubate VBN cord-015021-pol2qm74 2881 13 at at IN cord-015021-pol2qm74 2881 14 37 37 CD cord-015021-pol2qm74 2881 15 ° ° NN cord-015021-pol2qm74 2881 16 C c NN cord-015021-pol2qm74 2881 17 . . . cord-015021-pol2qm74 2882 1 OR or CC cord-015021-pol2qm74 2882 2 were be VBD cord-015021-pol2qm74 2882 3 produced produce VBN cord-015021-pol2qm74 2882 4 by by IN cord-015021-pol2qm74 2882 5 the the DT cord-015021-pol2qm74 2882 6 xanthine xanthine NN cord-015021-pol2qm74 2882 7 oxidase oxidase NN cord-015021-pol2qm74 2882 8 ( ( -LRB- cord-015021-pol2qm74 2882 9 XO)/ XO)/ NNP cord-015021-pol2qm74 2882 10 hypoxanthine hypoxanthine NNP cord-015021-pol2qm74 2882 11 ( ( -LRB- cord-015021-pol2qm74 2882 12 HX HX NNP cord-015021-pol2qm74 2882 13 ) ) -RRB- cord-015021-pol2qm74 2882 14 system system NN cord-015021-pol2qm74 2882 15 . . . cord-015021-pol2qm74 2883 1 After after IN cord-015021-pol2qm74 2883 2 0,30,60,120,240 0,30,60,120,240 CD cord-015021-pol2qm74 2883 3 and and CC cord-015021-pol2qm74 2883 4 360 360 CD cord-015021-pol2qm74 2883 5 minutes minute NNS cord-015021-pol2qm74 2883 6 plasma plasma NN cord-015021-pol2qm74 2883 7 levels level NNS cord-015021-pol2qm74 2883 8 of of IN cord-015021-pol2qm74 2883 9 TNF tnf NN cord-015021-pol2qm74 2883 10 - - HYPH cord-015021-pol2qm74 2883 11 alpha alpha NN cord-015021-pol2qm74 2883 12 , , , cord-015021-pol2qm74 2883 13 IL IL NNP cord-015021-pol2qm74 2883 14 - - : cord-015021-pol2qm74 2883 15 I I NNP cord-015021-pol2qm74 2883 16 beta beta NN cord-015021-pol2qm74 2883 17 and and CC cord-015021-pol2qm74 2884 1 IL-6 IL-6 NNP cord-015021-pol2qm74 2884 2 were be VBD cord-015021-pol2qm74 2884 3 determined determine VBN cord-015021-pol2qm74 2884 4 with with IN cord-015021-pol2qm74 2884 5 ELISA ELISA NNP cord-015021-pol2qm74 2884 6 kits kit NNS cord-015021-pol2qm74 2884 7 . . . cord-015021-pol2qm74 2885 1 Results result NNS cord-015021-pol2qm74 2885 2 : : : cord-015021-pol2qm74 2886 1 Under under IN cord-015021-pol2qm74 2886 2 the the DT cord-015021-pol2qm74 2886 3 influence influence NN cord-015021-pol2qm74 2886 4 of of IN cord-015021-pol2qm74 2886 5 OR OR NNP cord-015021-pol2qm74 2886 6 TNF TNF NNP cord-015021-pol2qm74 2886 7 - - HYPH cord-015021-pol2qm74 2886 8 alpha alpha NN cord-015021-pol2qm74 2886 9 plasma plasma NN cord-015021-pol2qm74 2886 10 levels level NNS cord-015021-pol2qm74 2886 11 increased increase VBD cord-015021-pol2qm74 2886 12 from from IN cord-015021-pol2qm74 2886 13 0,5 0,5 CD cord-015021-pol2qm74 2886 14 pg pg NNP cord-015021-pol2qm74 2886 15 / / SYM cord-015021-pol2qm74 2886 16 ml ml XX cord-015021-pol2qm74 2886 17 at at IN cord-015021-pol2qm74 2886 18 0min 0min CD cord-015021-pol2qm74 2886 19 to to IN cord-015021-pol2qm74 2887 1 14pg 14pg NNP cord-015021-pol2qm74 2887 2 / / SYM cord-015021-pol2qm74 2887 3 ml ml NN cord-015021-pol2qm74 2887 4 , , , cord-015021-pol2qm74 2887 5 236pg 236pg NNP cord-015021-pol2qm74 2887 6 / / SYM cord-015021-pol2qm74 2887 7 ml ml NN cord-015021-pol2qm74 2887 8 , , , cord-015021-pol2qm74 2887 9 343pg 343pg NNP cord-015021-pol2qm74 2887 10 / / SYM cord-015021-pol2qm74 2887 11 ml ml NN cord-015021-pol2qm74 2887 12 after after IN cord-015021-pol2qm74 2887 13 60 60 CD cord-015021-pol2qm74 2887 14 , , , cord-015021-pol2qm74 2887 15 120 120 CD cord-015021-pol2qm74 2887 16 and and CC cord-015021-pol2qm74 2887 17 240 240 CD cord-015021-pol2qm74 2887 18 min min NN cord-015021-pol2qm74 2887 19 . . . cord-015021-pol2qm74 2888 1 IL IL NNP cord-015021-pol2qm74 2888 2 - - HYPH cord-015021-pol2qm74 2888 3 ibeta ibeta NNP cord-015021-pol2qm74 2888 4 ( ( -LRB- cord-015021-pol2qm74 2888 5 0,3pg 0,3pg CD cord-015021-pol2qm74 2888 6 / / SYM cord-015021-pol2qm74 2888 7 ml ml NN cord-015021-pol2qm74 2888 8 , , , cord-015021-pol2qm74 2888 9 0,6pg 0,6pg CD cord-015021-pol2qm74 2889 1 /ml /ml NFP cord-015021-pol2qm74 2889 2 , , , cord-015021-pol2qm74 2889 3 1,5pg 1,5pg CD cord-015021-pol2qm74 2889 4 / / SYM cord-015021-pol2qm74 2889 5 ml ml NN cord-015021-pol2qm74 2889 6 , , , cord-015021-pol2qm74 2889 7 81pg 81pg NNP cord-015021-pol2qm74 2889 8 / / SYM cord-015021-pol2qm74 2889 9 ml ml NN cord-015021-pol2qm74 2889 10 and and CC cord-015021-pol2qm74 2889 11 169pg 169pg NNP cord-015021-pol2qm74 2889 12 / / SYM cord-015021-pol2qm74 2889 13 ml ml XX cord-015021-pol2qm74 2889 14 after after IN cord-015021-pol2qm74 2889 15 0,60,120,240 0,60,120,240 CD cord-015021-pol2qm74 2889 16 and and CC cord-015021-pol2qm74 2889 17 360min 360min CD cord-015021-pol2qm74 2889 18 ) ) -RRB- cord-015021-pol2qm74 2889 19 and and CC cord-015021-pol2qm74 2890 1 IL-6 IL-6 NNP cord-015021-pol2qm74 2890 2 ( ( -LRB- cord-015021-pol2qm74 2890 3 0,2pg 0,2pg CD cord-015021-pol2qm74 2890 4 / / SYM cord-015021-pol2qm74 2890 5 ml ml NN cord-015021-pol2qm74 2890 6 , , , cord-015021-pol2qm74 2890 7 l l NNP cord-015021-pol2qm74 2890 8 , , , cord-015021-pol2qm74 2890 9 lpg lpg NNP cord-015021-pol2qm74 2890 10 / / SYM cord-015021-pol2qm74 2890 11 ml ml XX cord-015021-pol2qm74 2890 12 , , , cord-015021-pol2qm74 2891 1 4,1pg 4,1pg CD cord-015021-pol2qm74 2891 2 / / SYM cord-015021-pol2qm74 2891 3 ml ml NN cord-015021-pol2qm74 2891 4 , , , cord-015021-pol2qm74 2891 5 58pg 58pg NN cord-015021-pol2qm74 2891 6 / / SYM cord-015021-pol2qm74 2891 7 ml ml NN cord-015021-pol2qm74 2891 8 and and CC cord-015021-pol2qm74 2891 9 72,9pg 72,9pg NNP cord-015021-pol2qm74 2891 10 / / SYM cord-015021-pol2qm74 2891 11 ml ml XX cord-015021-pol2qm74 2891 12 after after IN cord-015021-pol2qm74 2891 13 0,60,120,240 0,60,120,240 CD cord-015021-pol2qm74 2892 1 and and CC cord-015021-pol2qm74 2892 2 360min 360min CD cord-015021-pol2qm74 2892 3 ) ) -RRB- cord-015021-pol2qm74 2893 1 plasma plasma NN cord-015021-pol2qm74 2893 2 levels level NNS cord-015021-pol2qm74 2893 3 were be VBD cord-015021-pol2qm74 2893 4 increased increase VBN cord-015021-pol2qm74 2893 5 60min 60min NN cord-015021-pol2qm74 2893 6 later later RB cord-015021-pol2qm74 2893 7 than than IN cord-015021-pol2qm74 2893 8 TNF tnf NN cord-015021-pol2qm74 2893 9 - - HYPH cord-015021-pol2qm74 2893 10 alpha alpha NN cord-015021-pol2qm74 2893 11 . . . cord-015021-pol2qm74 2894 1 Summary summary NN cord-015021-pol2qm74 2894 2 : : : cord-015021-pol2qm74 2895 1 These these DT cord-015021-pol2qm74 2895 2 data datum NNS cord-015021-pol2qm74 2895 3 suggest suggest VBP cord-015021-pol2qm74 2895 4 that that IN cord-015021-pol2qm74 2895 5 OR or CC cord-015021-pol2qm74 2895 6 do do VBP cord-015021-pol2qm74 2895 7 not not RB cord-015021-pol2qm74 2895 8 only only RB cord-015021-pol2qm74 2895 9 play play VB cord-015021-pol2qm74 2895 10 an an DT cord-015021-pol2qm74 2895 11 important important JJ cord-015021-pol2qm74 2895 12 role role NN cord-015021-pol2qm74 2895 13 in in IN cord-015021-pol2qm74 2895 14 initial initial JJ cord-015021-pol2qm74 2895 15 accumulation accumulation NN cord-015021-pol2qm74 2895 16 and and CC cord-015021-pol2qm74 2895 17 activation activation NN cord-015021-pol2qm74 2895 18 of of IN cord-015021-pol2qm74 2895 19 PMN PMN NNP cord-015021-pol2qm74 2895 20 leukocytes leukocyte NNS cord-015021-pol2qm74 2895 21 but but CC cord-015021-pol2qm74 2895 22 also also RB cord-015021-pol2qm74 2895 23 lead lead VBP cord-015021-pol2qm74 2895 24 to to IN cord-015021-pol2qm74 2895 25 a a DT cord-015021-pol2qm74 2895 26 stimulation stimulation NN cord-015021-pol2qm74 2895 27 of of IN cord-015021-pol2qm74 2895 28 monocytes monocyte NNS cord-015021-pol2qm74 2895 29 to to TO cord-015021-pol2qm74 2895 30 produce produce VB cord-015021-pol2qm74 2895 31 the the DT cord-015021-pol2qm74 2895 32 acute acute JJ cord-015021-pol2qm74 2895 33 phase phase NN cord-015021-pol2qm74 2895 34 reaction reaction NN cord-015021-pol2qm74 2895 35 cytokins cytokins NNP cord-015021-pol2qm74 2895 36 TNF TNF NNP cord-015021-pol2qm74 2895 37 - - HYPH cord-015021-pol2qm74 2895 38 alpha alpha NN cord-015021-pol2qm74 2895 39 , , , cord-015021-pol2qm74 2895 40 IL IL NNP cord-015021-pol2qm74 2895 41 - - : cord-015021-pol2qm74 2895 42 I I NNP cord-015021-pol2qm74 2895 43 beta beta NN cord-015021-pol2qm74 2895 44 and and CC cord-015021-pol2qm74 2895 45 IL-6 IL-6 NNP cord-015021-pol2qm74 2895 46 to to TO cord-015021-pol2qm74 2895 47 maintain maintain VB cord-015021-pol2qm74 2895 48 and and CC cord-015021-pol2qm74 2895 49 strengthen strengthen VB cord-015021-pol2qm74 2895 50 the the DT cord-015021-pol2qm74 2895 51 inflammatory inflammatory JJ cord-015021-pol2qm74 2895 52 reaction reaction NN cord-015021-pol2qm74 2895 53 . . . cord-015021-pol2qm74 2896 1 Department Department NNP cord-015021-pol2qm74 2896 2 of of IN cord-015021-pol2qm74 2896 3 General General NNP cord-015021-pol2qm74 2896 4 Surgery Surgery NNP cord-015021-pol2qm74 2896 5 , , , cord-015021-pol2qm74 2896 6 SteinhSvelstr.9 SteinhSvelstr.9 NNP cord-015021-pol2qm74 2896 7 , , , cord-015021-pol2qm74 2896 8 89070 89070 CD cord-015021-pol2qm74 2896 9 Ulm Ulm NNP cord-015021-pol2qm74 2896 10 , , , cord-015021-pol2qm74 2896 11 Germany Germany NNP cord-015021-pol2qm74 2896 12 Jan Jan NNP cord-015021-pol2qm74 2896 13 K. K. NNP cord-015021-pol2qm74 2896 14 Horn Horn NNP cord-015021-pol2qm74 2896 15 MD MD NNP cord-015021-pol2qm74 2896 16 , , , cord-015021-pol2qm74 2896 17 Greg Greg NNP cord-015021-pol2qm74 2896 18 A. a. NN cord-015021-pol2qm74 2896 19 Hamon Hamon NNP cord-015021-pol2qm74 2896 20 MD MD NNP cord-015021-pol2qm74 2896 21 , , , cord-015021-pol2qm74 2896 22 Robert Robert NNP cord-015021-pol2qm74 2896 23 H. H. NNP cord-015021-pol2qm74 2896 24 Mulloy Mulloy NNP cord-015021-pol2qm74 2896 25 MD MD NNP cord-015021-pol2qm74 2896 26 , , , cord-015021-pol2qm74 2896 27 Greg Greg NNP cord-015021-pol2qm74 2896 28 Chen Chen NNP cord-015021-pol2qm74 2896 29 BS BS NNP cord-015021-pol2qm74 2896 30 , , , cord-015021-pol2qm74 2896 31 Rebecca Rebecca NNP cord-015021-pol2qm74 2896 32 Chow Chow NNP cord-015021-pol2qm74 2896 33 BS BS NNP cord-015021-pol2qm74 2896 34 , , , cord-015021-pol2qm74 2896 35 and and CC cord-015021-pol2qm74 2896 36 Christof Christof NNP cord-015021-pol2qm74 2896 37 Birkenmaier Birkenmaier NNP cord-015021-pol2qm74 2896 38 MD MD NNP cord-015021-pol2qm74 2896 39 . . . cord-015021-pol2qm74 2897 1 Transforming transform VBG cord-015021-pol2qm74 2897 2 growth growth NN cord-015021-pol2qm74 2897 3 factor factor NN cord-015021-pol2qm74 2897 4 - - : cord-015021-pol2qm74 2897 5 I i NN cord-015021-pol2qm74 2898 1 ~l ~l NNP cord-015021-pol2qm74 2898 2 ( ( -LRB- cord-015021-pol2qm74 2898 3 TGF-131 TGF-131 NNP cord-015021-pol2qm74 2898 4 ) ) -RRB- cord-015021-pol2qm74 2898 5 is be VBZ cord-015021-pol2qm74 2898 6 released release VBN cord-015021-pol2qm74 2898 7 from from IN cord-015021-pol2qm74 2898 8 inflammatory inflammatory JJ cord-015021-pol2qm74 2898 9 ceils ceil NNS cord-015021-pol2qm74 2898 10 following follow VBG cord-015021-pol2qm74 2898 11 injury injury NN cord-015021-pol2qm74 2898 12 and and CC cord-015021-pol2qm74 2898 13 in in IN cord-015021-pol2qm74 2898 14 sepsis sepsis NN cord-015021-pol2qm74 2898 15 . . . cord-015021-pol2qm74 2899 1 In in IN cord-015021-pol2qm74 2899 2 vitro vitro FW cord-015021-pol2qm74 2899 3 experiments experiment NNS cord-015021-pol2qm74 2899 4 have have VBP cord-015021-pol2qm74 2899 5 confirmed confirm VBN cord-015021-pol2qm74 2899 6 that that IN cord-015021-pol2qm74 2899 7 low low JJ cord-015021-pol2qm74 2899 8 concentrations concentration NNS cord-015021-pol2qm74 2899 9 of of IN cord-015021-pol2qm74 2899 10 TGF-131 TGF-131 NNP cord-015021-pol2qm74 2899 11 ( ( -LRB- cord-015021-pol2qm74 2899 12 0.1 0.1 CD cord-015021-pol2qm74 2899 13 - - SYM cord-015021-pol2qm74 2899 14 1.0 1.0 CD cord-015021-pol2qm74 2899 15 ng ng NN cord-015021-pol2qm74 2899 16 / / SYM cord-015021-pol2qm74 2899 17 ml ml NN cord-015021-pol2qm74 2899 18 ) ) -RRB- cord-015021-pol2qm74 2899 19 are be VBP cord-015021-pol2qm74 2899 20 chemoattractive chemoattractive JJ cord-015021-pol2qm74 2899 21 for for IN cord-015021-pol2qm74 2899 22 monocytes monocyte NNS cord-015021-pol2qm74 2899 23 , , , cord-015021-pol2qm74 2899 24 whereas whereas IN cord-015021-pol2qm74 2899 25 higher high JJR cord-015021-pol2qm74 2899 26 levels level NNS cord-015021-pol2qm74 2899 27 of of IN cord-015021-pol2qm74 2899 28 TGF-131 TGF-131 NNP cord-015021-pol2qm74 2899 29 ( ( -LRB- cord-015021-pol2qm74 2899 30 > > NFP cord-015021-pol2qm74 2899 31 5.0 5.0 CD cord-015021-pol2qm74 2899 32 ng ng NN cord-015021-pol2qm74 2899 33 / / SYM cord-015021-pol2qm74 2899 34 ml ml NN cord-015021-pol2qm74 2899 35 ) ) -RRB- cord-015021-pol2qm74 2899 36 potentiate potentiate VBP cord-015021-pol2qm74 2899 37 production production NN cord-015021-pol2qm74 2899 38 of of IN cord-015021-pol2qm74 2899 39 the the DT cord-015021-pol2qm74 2899 40 immunedepressive immunedepressive JJ cord-015021-pol2qm74 2899 41 prostaglandin prostaglandin NN cord-015021-pol2qm74 2899 42 E e NN cord-015021-pol2qm74 2899 43 2 2 CD cord-015021-pol2qm74 2899 44 . . . cord-015021-pol2qm74 2900 1 Other other JJ cord-015021-pol2qm74 2900 2 investigators investigator NNS cord-015021-pol2qm74 2900 3 have have VBP cord-015021-pol2qm74 2900 4 shown show VBN cord-015021-pol2qm74 2900 5 that that IN cord-015021-pol2qm74 2900 6 TGF-]31 tgf-]31 DT cord-015021-pol2qm74 2900 7 can can MD cord-015021-pol2qm74 2900 8 cause cause VB cord-015021-pol2qm74 2900 9 the the DT cord-015021-pol2qm74 2900 10 appearance appearance NN cord-015021-pol2qm74 2900 11 of of IN cord-015021-pol2qm74 2900 12 CD16 CD16 NNP cord-015021-pol2qm74 2900 13 ( ( -LRB- cord-015021-pol2qm74 2900 14 Fc Fc NNP cord-015021-pol2qm74 2900 15 immunoglobulin immunoglobulin NN cord-015021-pol2qm74 2900 16 receptor receptor NN cord-015021-pol2qm74 2900 17 ) ) -RRB- cord-015021-pol2qm74 2900 18 on on IN cord-015021-pol2qm74 2900 19 monocytes monocyte NNS cord-015021-pol2qm74 2900 20 exposed expose VBN cord-015021-pol2qm74 2900 21 to to IN cord-015021-pol2qm74 2900 22 10 10 CD cord-015021-pol2qm74 2900 23 ng ng NN cord-015021-pol2qm74 2900 24 / / SYM cord-015021-pol2qm74 2900 25 ml ml NNS cord-015021-pol2qm74 2900 26 of of IN cord-015021-pol2qm74 2900 27 TGF-[~I tgf-[~i NN cord-015021-pol2qm74 2900 28 for for IN cord-015021-pol2qm74 2900 29 24 24 CD cord-015021-pol2qm74 2900 30 hours hour NNS cord-015021-pol2qm74 2900 31 . . . cord-015021-pol2qm74 2901 1 Monocytes monocyte NNS cord-015021-pol2qm74 2901 2 also also RB cord-015021-pol2qm74 2901 3 express express VBP cord-015021-pol2qm74 2901 4 on on IN cord-015021-pol2qm74 2901 5 their -PRON- PRP$ cord-015021-pol2qm74 2901 6 surface surface NN cord-015021-pol2qm74 2901 7 a a DT cord-015021-pol2qm74 2901 8 glycoprotein glycoprotein NN cord-015021-pol2qm74 2901 9 that that WDT cord-015021-pol2qm74 2901 10 binds bind VBZ cord-015021-pol2qm74 2901 11 complexes complex NNS cord-015021-pol2qm74 2901 12 of of IN cord-015021-pol2qm74 2901 13 lipopolysaceharide lipopolysaceharide NN cord-015021-pol2qm74 2901 14 ( ( -LRB- cord-015021-pol2qm74 2901 15 LPS LPS NNP cord-015021-pol2qm74 2901 16 ) ) -RRB- cord-015021-pol2qm74 2901 17 and and CC cord-015021-pol2qm74 2901 18 LPSbinding lpsbinde VBG cord-015021-pol2qm74 2901 19 protein protein NN cord-015021-pol2qm74 2901 20 ( ( -LRB- cord-015021-pol2qm74 2901 21 LBP LBP NNP cord-015021-pol2qm74 2901 22 ) ) -RRB- cord-015021-pol2qm74 2901 23 . . . cord-015021-pol2qm74 2902 1 Such such JJ cord-015021-pol2qm74 2902 2 binding binding NN cord-015021-pol2qm74 2902 3 is be VBZ cord-015021-pol2qm74 2902 4 associated associate VBN cord-015021-pol2qm74 2902 5 with with IN cord-015021-pol2qm74 2902 6 generation generation NN cord-015021-pol2qm74 2902 7 of of IN cord-015021-pol2qm74 2902 8 proinflammatory proinflammatory JJ cord-015021-pol2qm74 2902 9 cytokines cytokine NNS cord-015021-pol2qm74 2902 10 such such JJ cord-015021-pol2qm74 2902 11 as as IN cord-015021-pol2qm74 2902 12 tumor tumor NN cord-015021-pol2qm74 2902 13 necrosis necrosis NN cord-015021-pol2qm74 2902 14 factor factor NN cord-015021-pol2qm74 2902 15 alpha alpha NN cord-015021-pol2qm74 2902 16 . . . cord-015021-pol2qm74 2903 1 We -PRON- PRP cord-015021-pol2qm74 2903 2 have have VBP cord-015021-pol2qm74 2903 3 shown show VBN cord-015021-pol2qm74 2903 4 that that IN cord-015021-pol2qm74 2903 5 CD14 CD14 NNP cord-015021-pol2qm74 2903 6 is be VBZ cord-015021-pol2qm74 2903 7 depressed depress VBN cord-015021-pol2qm74 2903 8 in in IN cord-015021-pol2qm74 2903 9 septic septic JJ cord-015021-pol2qm74 2903 10 patients patient NNS cord-015021-pol2qm74 2903 11 and and CC cord-015021-pol2qm74 2903 12 therefore therefore RB cord-015021-pol2qm74 2903 13 we -PRON- PRP cord-015021-pol2qm74 2903 14 hypothesized hypothesize VBD cord-015021-pol2qm74 2903 15 that that IN cord-015021-pol2qm74 2903 16 TGF-131 TGF-131 NNP cord-015021-pol2qm74 2903 17 could could MD cord-015021-pol2qm74 2903 18 account account VB cord-015021-pol2qm74 2903 19 for for IN cord-015021-pol2qm74 2903 20 the the DT cord-015021-pol2qm74 2903 21 down down JJ cord-015021-pol2qm74 2903 22 - - HYPH cord-015021-pol2qm74 2903 23 regulation regulation NN cord-015021-pol2qm74 2903 24 of of IN cord-015021-pol2qm74 2903 25 CD14 CD14 NNP cord-015021-pol2qm74 2903 26 observed observe VBD cord-015021-pol2qm74 2903 27 in in IN cord-015021-pol2qm74 2903 28 these these DT cord-015021-pol2qm74 2903 29 individuals individual NNS cord-015021-pol2qm74 2903 30 . . . cord-015021-pol2qm74 2904 1 We -PRON- PRP cord-015021-pol2qm74 2904 2 incubated incubate VBD cord-015021-pol2qm74 2904 3 normal normal JJ cord-015021-pol2qm74 2904 4 human human JJ cord-015021-pol2qm74 2904 5 monocytes monocyte NNS cord-015021-pol2qm74 2904 6 with with IN cord-015021-pol2qm74 2904 7 platelet platelet NN cord-015021-pol2qm74 2904 8 - - HYPH cord-015021-pol2qm74 2904 9 derived derive VBN cord-015021-pol2qm74 2904 10 TGF-[31 tgf-[31 RB cord-015021-pol2qm74 2904 11 for for IN cord-015021-pol2qm74 2904 12 2 2 CD cord-015021-pol2qm74 2904 13 and and CC cord-015021-pol2qm74 2904 14 24 24 CD cord-015021-pol2qm74 2904 15 hours hour NNS cord-015021-pol2qm74 2904 16 at at IN cord-015021-pol2qm74 2904 17 37 37 CD cord-015021-pol2qm74 2904 18 ° ° NN cord-015021-pol2qm74 2904 19 C c NN cord-015021-pol2qm74 2904 20 and and CC cord-015021-pol2qm74 2904 21 examined examine VBD cord-015021-pol2qm74 2904 22 ceils ceil NNS cord-015021-pol2qm74 2904 23 for for IN cord-015021-pol2qm74 2904 24 CD14 CD14 NNP cord-015021-pol2qm74 2904 25 and and CC cord-015021-pol2qm74 2904 26 CD16 CD16 NNP cord-015021-pol2qm74 2904 27 expression expression NN cord-015021-pol2qm74 2904 28 using use VBG cord-015021-pol2qm74 2904 29 flow flow NN cord-015021-pol2qm74 2904 30 cytometry cytometry NN cord-015021-pol2qm74 2904 31 after after IN cord-015021-pol2qm74 2904 32 immunnfluoreseent immunnfluoreseent NN cord-015021-pol2qm74 2904 33 staining stain VBG cord-015021-pol2qm74 2904 34 with with IN cord-015021-pol2qm74 2904 35 appropriate appropriate JJ cord-015021-pol2qm74 2904 36 monoclonal monoclonal JJ cord-015021-pol2qm74 2904 37 antibodies antibody NNS cord-015021-pol2qm74 2904 38 . . . cord-015021-pol2qm74 2905 1 Monocytes monocyte NNS cord-015021-pol2qm74 2905 2 were be VBD cord-015021-pol2qm74 2905 3 selected select VBN cord-015021-pol2qm74 2905 4 on on IN cord-015021-pol2qm74 2905 5 the the DT cord-015021-pol2qm74 2905 6 by by IN cord-015021-pol2qm74 2905 7 usual usual JJ cord-015021-pol2qm74 2905 8 criteria criterion NNS cord-015021-pol2qm74 2905 9 for for IN cord-015021-pol2qm74 2905 10 size size NN cord-015021-pol2qm74 2905 11 and and CC cord-015021-pol2qm74 2905 12 granularity granularity NN cord-015021-pol2qm74 2905 13 . . . cord-015021-pol2qm74 2906 1 Non non JJ cord-015021-pol2qm74 2906 2 - - JJ cord-015021-pol2qm74 2906 3 viable viable JJ cord-015021-pol2qm74 2906 4 ceils ceil NNS cord-015021-pol2qm74 2906 5 were be VBD cord-015021-pol2qm74 2906 6 excluded exclude VBN cord-015021-pol2qm74 2906 7 with with IN cord-015021-pol2qm74 2906 8 the the DT cord-015021-pol2qm74 2906 9 use use NN cord-015021-pol2qm74 2906 10 of of IN cord-015021-pol2qm74 2906 11 propidium propidium NN cord-015021-pol2qm74 2906 12 iodide iodide NN cord-015021-pol2qm74 2906 13 . . . cord-015021-pol2qm74 2907 1 Two two CD cord-015021-pol2qm74 2907 2 populations population NNS cord-015021-pol2qm74 2907 3 of of IN cord-015021-pol2qm74 2907 4 monocytes monocyte NNS cord-015021-pol2qm74 2907 5 could could MD cord-015021-pol2qm74 2907 6 be be VB cord-015021-pol2qm74 2907 7 found find VBN cord-015021-pol2qm74 2907 8 afcer afcer NNP cord-015021-pol2qm74 2907 9 incubation incubation NN cord-015021-pol2qm74 2907 10 at at IN cord-015021-pol2qm74 2907 11 37 37 CD cord-015021-pol2qm74 2907 12 ° ° NN cord-015021-pol2qm74 2907 13 C c NN cord-015021-pol2qm74 2907 14 alone alone RB cord-015021-pol2qm74 2907 15 . . . cord-015021-pol2qm74 2908 1 One one CD cord-015021-pol2qm74 2908 2 displaying display VBG cord-015021-pol2qm74 2908 3 high high JJ cord-015021-pol2qm74 2908 4 density density NN cord-015021-pol2qm74 2908 5 of of IN cord-015021-pol2qm74 2908 6 CD14 CD14 NNP cord-015021-pol2qm74 2908 7 had have VBD cord-015021-pol2qm74 2908 8 increased increase VBN cord-015021-pol2qm74 2908 9 fluorescence fluorescence NN cord-015021-pol2qm74 2908 10 over over IN cord-015021-pol2qm74 2908 11 the the DT cord-015021-pol2qm74 2908 12 homogeneous homogeneous JJ cord-015021-pol2qm74 2908 13 expression expression NN cord-015021-pol2qm74 2908 14 of of IN cord-015021-pol2qm74 2908 15 CD14 CD14 NNP cord-015021-pol2qm74 2908 16 in in IN cord-015021-pol2qm74 2908 17 cells cell NNS cord-015021-pol2qm74 2908 18 maintained maintain VBD cord-015021-pol2qm74 2908 19 at at IN cord-015021-pol2qm74 2908 20 4 4 CD cord-015021-pol2qm74 2908 21 ° ° NN cord-015021-pol2qm74 2908 22 C c NN cord-015021-pol2qm74 2908 23 ( ( -LRB- cord-015021-pol2qm74 2908 24 baseline baseline NN cord-015021-pol2qm74 2908 25 ) ) -RRB- cord-015021-pol2qm74 2908 26 . . . cord-015021-pol2qm74 2909 1 The the DT cord-015021-pol2qm74 2909 2 other other JJ cord-015021-pol2qm74 2909 3 population population NN cord-015021-pol2qm74 2909 4 displayed display VBD cord-015021-pol2qm74 2909 5 decreased decrease VBN cord-015021-pol2qm74 2909 6 CD14 CD14 NNP cord-015021-pol2qm74 2909 7 expression expression NN cord-015021-pol2qm74 2909 8 relative relative JJ cord-015021-pol2qm74 2909 9 to to IN cord-015021-pol2qm74 2909 10 the the DT cord-015021-pol2qm74 2909 11 baseline baseline JJ cord-015021-pol2qm74 2909 12 cells cell NNS cord-015021-pol2qm74 2909 13 . . . cord-015021-pol2qm74 2910 1 TGF TGF NNP cord-015021-pol2qm74 2910 2 - - HYPH cord-015021-pol2qm74 2910 3 I I NNP cord-015021-pol2qm74 2911 1 ~I ~I NFP cord-015021-pol2qm74 2911 2 ( ( -LRB- cord-015021-pol2qm74 2911 3 10 10 CD cord-015021-pol2qm74 2911 4 - - SYM cord-015021-pol2qm74 2911 5 50 50 CD cord-015021-pol2qm74 2911 6 ng ng NN cord-015021-pol2qm74 2911 7 / / SYM cord-015021-pol2qm74 2911 8 ml ml NN cord-015021-pol2qm74 2911 9 ) ) -RRB- cord-015021-pol2qm74 2911 10 caused cause VBD cord-015021-pol2qm74 2911 11 a a DT cord-015021-pol2qm74 2911 12 shift shift NN cord-015021-pol2qm74 2911 13 of of IN cord-015021-pol2qm74 2911 14 ceils ceil NNS cord-015021-pol2qm74 2911 15 from from IN cord-015021-pol2qm74 2911 16 the the DT cord-015021-pol2qm74 2911 17 high high JJ cord-015021-pol2qm74 2911 18 density density NN cord-015021-pol2qm74 2911 19 into into IN cord-015021-pol2qm74 2911 20 the the DT cord-015021-pol2qm74 2911 21 low low JJ cord-015021-pol2qm74 2911 22 density density NN cord-015021-pol2qm74 2911 23 CD14 CD14 NNP cord-015021-pol2qm74 2911 24 population population NN cord-015021-pol2qm74 2911 25 . . . cord-015021-pol2qm74 2912 1 This this DT cord-015021-pol2qm74 2912 2 trend trend NN cord-015021-pol2qm74 2912 3 was be VBD cord-015021-pol2qm74 2912 4 observed observe VBN cord-015021-pol2qm74 2912 5 within within IN cord-015021-pol2qm74 2912 6 2 2 CD cord-015021-pol2qm74 2912 7 hours hour NNS cord-015021-pol2qm74 2912 8 of of IN cord-015021-pol2qm74 2912 9 incubation incubation NN cord-015021-pol2qm74 2912 10 and and CC cord-015021-pol2qm74 2912 11 was be VBD cord-015021-pol2qm74 2912 12 complete complete JJ cord-015021-pol2qm74 2912 13 by by IN cord-015021-pol2qm74 2912 14 24 24 CD cord-015021-pol2qm74 2912 15 hours hour NNS cord-015021-pol2qm74 2912 16 . . . cord-015021-pol2qm74 2913 1 We -PRON- PRP cord-015021-pol2qm74 2913 2 observed observe VBD cord-015021-pol2qm74 2913 3 a a DT cord-015021-pol2qm74 2913 4 net net JJ cord-015021-pol2qm74 2913 5 decrease decrease NN cord-015021-pol2qm74 2913 6 in in IN cord-015021-pol2qm74 2913 7 CD14 CD14 NNP cord-015021-pol2qm74 2913 8 expression expression NN cord-015021-pol2qm74 2913 9 0f32 0f32 CD cord-015021-pol2qm74 2913 10 % % NN cord-015021-pol2qm74 2913 11 for for IN cord-015021-pol2qm74 2913 12 all all DT cord-015021-pol2qm74 2913 13 subjects subject NNS cord-015021-pol2qm74 2913 14 studied study VBD cord-015021-pol2qm74 2913 15 ( ( -LRB- cord-015021-pol2qm74 2913 16 p<0.05 p<0.05 NNP cord-015021-pol2qm74 2913 17 vs vs IN cord-015021-pol2qm74 2913 18 controls control NNS cord-015021-pol2qm74 2913 19 ) ) -RRB- cord-015021-pol2qm74 2913 20 . . . cord-015021-pol2qm74 2914 1 Phorbol Phorbol NNP cord-015021-pol2qm74 2914 2 myristate myristate NN cord-015021-pol2qm74 2914 3 acetate acetate NN cord-015021-pol2qm74 2914 4 ( ( -LRB- cord-015021-pol2qm74 2914 5 100 100 CD cord-015021-pol2qm74 2914 6 ng ng NN cord-015021-pol2qm74 2914 7 / / SYM cord-015021-pol2qm74 2914 8 ml ml NN cord-015021-pol2qm74 2914 9 ) ) -RRB- cord-015021-pol2qm74 2914 10 also also RB cord-015021-pol2qm74 2914 11 caused cause VBD cord-015021-pol2qm74 2914 12 down down NN cord-015021-pol2qm74 2914 13 - - HYPH cord-015021-pol2qm74 2914 14 regulation regulation NN cord-015021-pol2qm74 2914 15 of of IN cord-015021-pol2qm74 2914 16 CD14 CD14 NNP cord-015021-pol2qm74 2914 17 to to IN cord-015021-pol2qm74 2914 18 a a DT cord-015021-pol2qm74 2914 19 similar similar JJ cord-015021-pol2qm74 2914 20 degree degree NN cord-015021-pol2qm74 2914 21 as as IN cord-015021-pol2qm74 2914 22 TFG TFG NNP cord-015021-pol2qm74 2914 23 - - HYPH cord-015021-pol2qm74 2914 24 I~ I~ NNP cord-015021-pol2qm74 2915 1 I. i. LS cord-015021-pol2qm74 2915 2 We -PRON- PRP cord-015021-pol2qm74 2915 3 also also RB cord-015021-pol2qm74 2915 4 confirmed confirm VBD cord-015021-pol2qm74 2915 5 that that IN cord-015021-pol2qm74 2915 6 monocytes monocyte NNS cord-015021-pol2qm74 2915 7 could could MD cord-015021-pol2qm74 2915 8 be be VB cord-015021-pol2qm74 2915 9 induced induce VBN cord-015021-pol2qm74 2915 10 to to TO cord-015021-pol2qm74 2915 11 express express VB cord-015021-pol2qm74 2915 12 CD16 CD16 NNP cord-015021-pol2qm74 2915 13 after after IN cord-015021-pol2qm74 2915 14 incubation incubation NN cord-015021-pol2qm74 2915 15 with with IN cord-015021-pol2qm74 2915 16 TGF-131 TGF-131 NNP cord-015021-pol2qm74 2915 17 ( ( -LRB- cord-015021-pol2qm74 2915 18 10 10 CD cord-015021-pol2qm74 2915 19 ng ng NN cord-015021-pol2qm74 2915 20 / / SYM cord-015021-pol2qm74 2915 21 ml ml NN cord-015021-pol2qm74 2915 22 ) ) -RRB- cord-015021-pol2qm74 2915 23 for for IN cord-015021-pol2qm74 2915 24 24 24 CD cord-015021-pol2qm74 2915 25 hours hour NNS cord-015021-pol2qm74 2915 26 . . . cord-015021-pol2qm74 2916 1 These these DT cord-015021-pol2qm74 2916 2 studies study NNS cord-015021-pol2qm74 2916 3 demonstrate demonstrate VBP cord-015021-pol2qm74 2916 4 that that IN cord-015021-pol2qm74 2916 5 monocytes monocyte NNS cord-015021-pol2qm74 2916 6 incubated incubate VBN cord-015021-pol2qm74 2916 7 with with IN cord-015021-pol2qm74 2916 8 immunodepressive immunodepressive JJ cord-015021-pol2qm74 2916 9 levels level NNS cord-015021-pol2qm74 2916 10 of of IN cord-015021-pol2qm74 2916 11 regulation regulation NN cord-015021-pol2qm74 2916 12 of of IN cord-015021-pol2qm74 2916 13 CD14 CD14 NNP cord-015021-pol2qm74 2916 14 by by IN cord-015021-pol2qm74 2916 15 TGF-131 TGF-131 NNP cord-015021-pol2qm74 2916 16 deplete deplete VBP cord-015021-pol2qm74 2916 17 their -PRON- PRP$ cord-015021-pol2qm74 2916 18 surface surface NN cord-015021-pol2qm74 2916 19 expression expression NN cord-015021-pol2qm74 2916 20 of of IN cord-015021-pol2qm74 2916 21 CD14 CD14 NNP cord-015021-pol2qm74 2916 22 while while IN cord-015021-pol2qm74 2916 23 generating generate VBG cord-015021-pol2qm74 2916 24 CD16 CD16 NNP cord-015021-pol2qm74 2916 25 . . . cord-015021-pol2qm74 2917 1 This this DT cord-015021-pol2qm74 2917 2 down down JJ cord-015021-pol2qm74 2917 3 - - HYPH cord-015021-pol2qm74 2917 4 regulation regulation NN cord-015021-pol2qm74 2917 5 of of IN cord-015021-pol2qm74 2917 6 CD14 CD14 NNP cord-015021-pol2qm74 2917 7 by by IN cord-015021-pol2qm74 2917 8 TGF-131 TGF-131 NNP cord-015021-pol2qm74 2917 9 correlates correlate VBZ cord-015021-pol2qm74 2917 10 with with IN cord-015021-pol2qm74 2917 11 our -PRON- PRP$ cord-015021-pol2qm74 2917 12 clinical clinical JJ cord-015021-pol2qm74 2917 13 observations observation NNS cord-015021-pol2qm74 2917 14 of of IN cord-015021-pol2qm74 2917 15 lower low JJR cord-015021-pol2qm74 2917 16 CD14 CD14 NNP cord-015021-pol2qm74 2917 17 expression expression NN cord-015021-pol2qm74 2917 18 on on IN cord-015021-pol2qm74 2917 19 monocytes monocyte NNS cord-015021-pol2qm74 2917 20 obtained obtain VBN cord-015021-pol2qm74 2917 21 from from IN cord-015021-pol2qm74 2917 22 septic septic JJ cord-015021-pol2qm74 2917 23 patients patient NNS cord-015021-pol2qm74 2917 24 . . . cord-015021-pol2qm74 2918 1 For for IN cord-015021-pol2qm74 2918 2 over over IN cord-015021-pol2qm74 2918 3 25 25 CD cord-015021-pol2qm74 2918 4 years year NNS cord-015021-pol2qm74 2918 5 , , , cord-015021-pol2qm74 2918 6 activated activate VBD cord-015021-pol2qm74 2918 7 T t NN cord-015021-pol2qm74 2918 8 lymphocytes lymphocyte NNS cord-015021-pol2qm74 2918 9 have have VBP cord-015021-pol2qm74 2918 10 been be VBN cord-015021-pol2qm74 2918 11 considered consider VBN cord-015021-pol2qm74 2918 12 to to TO cord-015021-pol2qm74 2918 13 be be VB cord-015021-pol2qm74 2918 14 the the DT cord-015021-pol2qm74 2918 15 cellular cellular JJ cord-015021-pol2qm74 2918 16 source source NN cord-015021-pol2qm74 2918 17 of of IN cord-015021-pol2qm74 2918 18 MIF MIF NNP cord-015021-pol2qm74 2918 19 . . . cord-015021-pol2qm74 2919 1 We -PRON- PRP cord-015021-pol2qm74 2919 2 recently recently RB cord-015021-pol2qm74 2919 3 isolated isolate VBD cord-015021-pol2qm74 2919 4 and and CC cord-015021-pol2qm74 2919 5 cloned clone VBN cord-015021-pol2qm74 2919 6 the the DT cord-015021-pol2qm74 2919 7 murine murine JJ cord-015021-pol2qm74 2919 8 homolog homolog NN cord-015021-pol2qm74 2919 9 of of IN cord-015021-pol2qm74 2919 10 MIF MIF NNP cord-015021-pol2qm74 2919 11 after after IN cord-015021-pol2qm74 2919 12 identifying identify VBG cord-015021-pol2qm74 2919 13 the the DT cord-015021-pol2qm74 2919 14 specific specific JJ cord-015021-pol2qm74 2919 15 secretion secretion NN cord-015021-pol2qm74 2919 16 of of IN cord-015021-pol2qm74 2919 17 this this DT cord-015021-pol2qm74 2919 18 protein protein NN cord-015021-pol2qm74 2919 19 by by IN cord-015021-pol2qm74 2919 20 LPSstimulated lpsstimulated JJ cord-015021-pol2qm74 2919 21 pituitary pituitary NN cord-015021-pol2qm74 2919 22 cells cell NNS cord-015021-pol2qm74 2919 23 in in IN cord-015021-pol2qm74 2919 24 vitro vitro FW cord-015021-pol2qm74 2919 25 and and CC cord-015021-pol2qm74 2919 26 in in IN cord-015021-pol2qm74 2919 27 vivo vivo NNP cord-015021-pol2qm74 2919 28 . . . cord-015021-pol2qm74 2920 1 However however RB cord-015021-pol2qm74 2920 2 , , , cord-015021-pol2qm74 2920 3 further further JJ cord-015021-pol2qm74 2920 4 experiments experiment NNS cord-015021-pol2qm74 2920 5 showed show VBD cord-015021-pol2qm74 2920 6 that that IN cord-015021-pol2qm74 2920 7 MIF MIF NNP cord-015021-pol2qm74 2920 8 protein protein NN cord-015021-pol2qm74 2920 9 is be VBZ cord-015021-pol2qm74 2920 10 detectable detectable JJ cord-015021-pol2qm74 2920 11 both both DT cord-015021-pol2qm74 2920 12 in in IN cord-015021-pol2qm74 2920 13 T t NN cord-015021-pol2qm74 2920 14 - - HYPH cord-015021-pol2qm74 2920 15 cell cell NN cord-015021-pol2qm74 2920 16 deficient deficient JJ cord-015021-pol2qm74 2920 17 ( ( -LRB- cord-015021-pol2qm74 2920 18 nude nude JJ cord-015021-pol2qm74 2920 19 ) ) -RRB- cord-015021-pol2qm74 2920 20 and and CC cord-015021-pol2qm74 2920 21 hypophyseetomized hypophyseetomize VBN cord-015021-pol2qm74 2920 22 mice mouse NNS cord-015021-pol2qm74 2920 23 , , , cord-015021-pol2qm74 2920 24 suggesting suggest VBG cord-015021-pol2qm74 2920 25 that that IN cord-015021-pol2qm74 2920 26 yet yet RB cord-015021-pol2qm74 2920 27 additional additional JJ cord-015021-pol2qm74 2920 28 cell cell NN cord-015021-pol2qm74 2920 29 types type NNS cord-015021-pol2qm74 2920 30 may may MD cord-015021-pol2qm74 2920 31 produce produce VB cord-015021-pol2qm74 2920 32 MIF MIF NNP cord-015021-pol2qm74 2920 33 in in IN cord-015021-pol2qm74 2920 34 vivo vivo NN cord-015021-pol2qm74 2920 35 . . . cord-015021-pol2qm74 2921 1 Since since IN cord-015021-pol2qm74 2921 2 monocytes monocyte NNS cord-015021-pol2qm74 2921 3 / / SYM cord-015021-pol2qm74 2921 4 macrophages macrophage NNS cord-015021-pol2qm74 2921 5 are be VBP cord-015021-pol2qm74 2921 6 a a DT cord-015021-pol2qm74 2921 7 major major JJ cord-015021-pol2qm74 2921 8 source source NN cord-015021-pol2qm74 2921 9 of of IN cord-015021-pol2qm74 2921 10 the the DT cord-015021-pol2qm74 2921 11 cytokines cytokine NNS cord-015021-pol2qm74 2921 12 that that WDT cord-015021-pol2qm74 2921 13 appear appear VBP cord-015021-pol2qm74 2921 14 in in IN cord-015021-pol2qm74 2921 15 response response NN cord-015021-pol2qm74 2921 16 to to IN cord-015021-pol2qm74 2921 17 LPS LPS NNP cord-015021-pol2qm74 2921 18 administration administration NN cord-015021-pol2qm74 2921 19 , , , cord-015021-pol2qm74 2921 20 we -PRON- PRP cord-015021-pol2qm74 2921 21 examined examine VBD cord-015021-pol2qm74 2921 22 the the DT cord-015021-pol2qm74 2921 23 possibility possibility NN cord-015021-pol2qm74 2921 24 that that IN cord-015021-pol2qm74 2921 25 MIF MIF NNP cord-015021-pol2qm74 2921 26 also also RB cord-015021-pol2qm74 2921 27 is be VBZ cord-015021-pol2qm74 2921 28 expressed express VBN cord-015021-pol2qm74 2921 29 in in IN cord-015021-pol2qm74 2921 30 cells cell NNS cord-015021-pol2qm74 2921 31 of of IN cord-015021-pol2qm74 2921 32 the the DT cord-015021-pol2qm74 2921 33 monocyte monocyte NNP cord-015021-pol2qm74 2921 34 / / SYM cord-015021-pol2qm74 2921 35 macrophage macrophage NN cord-015021-pol2qm74 2921 36 lineage lineage NN cord-015021-pol2qm74 2921 37 . . . cord-015021-pol2qm74 2922 1 We -PRON- PRP cord-015021-pol2qm74 2922 2 found find VBD cord-015021-pol2qm74 2922 3 that that IN cord-015021-pol2qm74 2922 4 MIF MIF NNP cord-015021-pol2qm74 2922 5 is be VBZ cord-015021-pol2qm74 2922 6 expressed express VBN cord-015021-pol2qm74 2922 7 constitutively constitutively RB cord-015021-pol2qm74 2922 8 in in IN cord-015021-pol2qm74 2922 9 the the DT cord-015021-pol2qm74 2922 10 murine murine JJ cord-015021-pol2qm74 2922 11 macrophage macrophage NN cord-015021-pol2qm74 2922 12 - - HYPH cord-015021-pol2qm74 2922 13 line line NN cord-015021-pol2qm74 2922 14 RAW264.7 RAW264.7 NNP cord-015021-pol2qm74 2922 15 and and CC cord-015021-pol2qm74 2922 16 in in IN cord-015021-pol2qm74 2922 17 thioglycollate thioglycollate RB cord-015021-pol2qm74 2922 18 - - HYPH cord-015021-pol2qm74 2922 19 elicited elicit VBN cord-015021-pol2qm74 2922 20 peritoneal peritoneal JJ cord-015021-pol2qm74 2922 21 macrophages macrophage NNS cord-015021-pol2qm74 2922 22 . . . cord-015021-pol2qm74 2923 1 Significant significant JJ cord-015021-pol2qm74 2923 2 amounts amount NNS cord-015021-pol2qm74 2923 3 of of IN cord-015021-pol2qm74 2923 4 MIF MIF NNP cord-015021-pol2qm74 2923 5 mRNA mRNA NNP cord-015021-pol2qm74 2923 6 ( ( -LRB- cord-015021-pol2qm74 2923 7 RT RT NNP cord-015021-pol2qm74 2923 8 - - HYPH cord-015021-pol2qm74 2923 9 PCR PCR NNP cord-015021-pol2qm74 2923 10 ) ) -RRB- cord-015021-pol2qm74 2923 11 and and CC cord-015021-pol2qm74 2923 12 protein protein NN cord-015021-pol2qm74 2923 13 ( ( -LRB- cord-015021-pol2qm74 2923 14 Western western JJ cord-015021-pol2qm74 2923 15 blotting blotting NN cord-015021-pol2qm74 2923 16 ) ) -RRB- cord-015021-pol2qm74 2923 17 were be VBD cord-015021-pol2qm74 2923 18 observed observe VBN cord-015021-pol2qm74 2923 19 in in IN cord-015021-pol2qm74 2923 20 cell cell NN cord-015021-pol2qm74 2923 21 lysates lysate NNS cord-015021-pol2qm74 2923 22 . . . cord-015021-pol2qm74 2924 1 In in IN cord-015021-pol2qm74 2924 2 RAW raw JJ cord-015021-pol2qm74 2924 3 264.7 264.7 CD cord-015021-pol2qm74 2924 4 cells cell NNS cord-015021-pol2qm74 2924 5 , , , cord-015021-pol2qm74 2924 6 MIF MIF NNP cord-015021-pol2qm74 2924 7 secretion secretion NN cord-015021-pol2qm74 2924 8 was be VBD cord-015021-pol2qm74 2924 9 induced induce VBN cord-015021-pol2qm74 2924 10 by by IN cord-015021-pol2qm74 2924 11 as as RB cord-015021-pol2qm74 2924 12 little little JJ cord-015021-pol2qm74 2924 13 as as IN cord-015021-pol2qm74 2924 14 10 10 CD cord-015021-pol2qm74 2924 15 pg pg NN cord-015021-pol2qm74 2924 16 / / SYM cord-015021-pol2qm74 2924 17 ml ml NNS cord-015021-pol2qm74 2924 18 of of IN cord-015021-pol2qm74 2924 19 LPS LPS NNP cord-015021-pol2qm74 2924 20 ( ( -LRB- cord-015021-pol2qm74 2924 21 E.coli E.coli NNS cord-015021-pol2qm74 2924 22 011 011 CD cord-015021-pol2qm74 2924 23 l l NN cord-015021-pol2qm74 2924 24 : : : cord-015021-pol2qm74 2924 25 B4 B4 NNP cord-015021-pol2qm74 2924 26 ) ) -RRB- cord-015021-pol2qm74 2924 27 , , , cord-015021-pol2qm74 2924 28 peaked peak VBD cord-015021-pol2qm74 2924 29 at at IN cord-015021-pol2qm74 2924 30 1 1 CD cord-015021-pol2qm74 2924 31 ng ng NN cord-015021-pol2qm74 2924 32 / / SYM cord-015021-pol2qm74 2924 33 ml ml XX cord-015021-pol2qm74 2924 34 , , , cord-015021-pol2qm74 2924 35 but but CC cord-015021-pol2qm74 2924 36 was be VBD cord-015021-pol2qm74 2924 37 not not RB cord-015021-pol2qm74 2924 38 detectable detectable JJ cord-015021-pol2qm74 2924 39 at at IN cord-015021-pol2qm74 2924 40 LPS LPS NNP cord-015021-pol2qm74 2924 41 concentrations concentration NNS cord-015021-pol2qm74 2925 1 > > XX cord-015021-pol2qm74 2926 1 1 1 CD cord-015021-pol2qm74 2926 2 txg txg NNP cord-015021-pol2qm74 2926 3 / / SYM cord-015021-pol2qm74 2926 4 ml ml NN cord-015021-pol2qm74 2926 5 . . . cord-015021-pol2qm74 2927 1 Similar similar JJ cord-015021-pol2qm74 2927 2 data datum NNS cord-015021-pol2qm74 2927 3 were be VBD cord-015021-pol2qm74 2927 4 obtained obtain VBN cord-015021-pol2qm74 2927 5 with with IN cord-015021-pol2qm74 2927 6 elicited elicit VBN cord-015021-pol2qm74 2927 7 macrophages macrophage NNS cord-015021-pol2qm74 2927 8 , , , cord-015021-pol2qm74 2927 9 but but CC cord-015021-pol2qm74 2927 10 higher high JJR cord-015021-pol2qm74 2927 11 LPS LPS NNP cord-015021-pol2qm74 2927 12 concentrations concentration NNS cord-015021-pol2qm74 2927 13 were be VBD cord-015021-pol2qm74 2927 14 required require VBN cord-015021-pol2qm74 2927 15 , , , cord-015021-pol2qm74 2927 16 unless unless IN cord-015021-pol2qm74 2927 17 the the DT cord-015021-pol2qm74 2927 18 cells cell NNS cord-015021-pol2qm74 2927 19 had have VBD cord-015021-pol2qm74 2927 20 been be VBN cord-015021-pol2qm74 2927 21 preincubated preincubate VBN cord-015021-pol2qm74 2927 22 with with IN cord-015021-pol2qm74 2927 23 IFN IFN NNP cord-015021-pol2qm74 2927 24 7 7 CD cord-015021-pol2qm74 2927 25 . . . cord-015021-pol2qm74 2928 1 Production production NN cord-015021-pol2qm74 2928 2 of of IN cord-015021-pol2qm74 2928 3 MIF MIF NNP cord-015021-pol2qm74 2928 4 by by IN cord-015021-pol2qm74 2928 5 LPS LPS NNP cord-015021-pol2qm74 2928 6 - - HYPH cord-015021-pol2qm74 2928 7 stimulated stimulate VBN cord-015021-pol2qm74 2928 8 ( ( -LRB- cord-015021-pol2qm74 2928 9 l l NNP cord-015021-pol2qm74 2928 10 ng ng NNP cord-015021-pol2qm74 2928 11 / / SYM cord-015021-pol2qm74 2928 12 ml ml NN cord-015021-pol2qm74 2928 13 ) ) -RRB- cord-015021-pol2qm74 2928 14 macrophages macrophage NNS cord-015021-pol2qm74 2928 15 peaked peak VBD cord-015021-pol2qm74 2928 16 at at IN cord-015021-pol2qm74 2928 17 12 12 CD cord-015021-pol2qm74 2928 18 hr hr NN cord-015021-pol2qm74 2928 19 . . . cord-015021-pol2qm74 2929 1 Expression expression NN cord-015021-pol2qm74 2929 2 ofMIF ofmif JJ cord-015021-pol2qm74 2930 1 mRNA mRNA NNP cord-015021-pol2qm74 2930 2 and and CC cord-015021-pol2qm74 2931 1 TNF TNF NNP cord-015021-pol2qm74 2931 2 mRNA mRNA NNP cord-015021-pol2qm74 2932 1 by by IN cord-015021-pol2qm74 2932 2 LPS LPS NNP cord-015021-pol2qm74 2932 3 - - HYPH cord-015021-pol2qm74 2932 4 stimulated stimulate VBN cord-015021-pol2qm74 2932 5 RAW raw JJ cord-015021-pol2qm74 2932 6 264.7 264.7 CD cord-015021-pol2qm74 2932 7 macrophages macrophage NNS cord-015021-pol2qm74 2932 8 was be VBD cord-015021-pol2qm74 2932 9 investigated investigate VBN cord-015021-pol2qm74 2932 10 by by IN cord-015021-pol2qm74 2932 11 RT RT NNP cord-015021-pol2qm74 2932 12 - - HYPH cord-015021-pol2qm74 2932 13 PCR PCR NNP cord-015021-pol2qm74 2932 14 . . . cord-015021-pol2qm74 2933 1 As as IN cord-015021-pol2qm74 2933 2 expected expect VBN cord-015021-pol2qm74 2933 3 TNF TNF NNP cord-015021-pol2qm74 2933 4 mRNA mrna NN cord-015021-pol2qm74 2933 5 expression expression NN cord-015021-pol2qm74 2933 6 increased increase VBD cord-015021-pol2qm74 2933 7 over over IN cord-015021-pol2qm74 2933 8 the the DT cord-015021-pol2qm74 2933 9 range range NN cord-015021-pol2qm74 2933 10 of of IN cord-015021-pol2qm74 2933 11 LPS LPS NNP cord-015021-pol2qm74 2933 12 concentrations concentration NNS cord-015021-pol2qm74 2933 13 ( ( -LRB- cord-015021-pol2qm74 2933 14 1 1 CD cord-015021-pol2qm74 2933 15 pg pg NN cord-015021-pol2qm74 2933 16 / / SYM cord-015021-pol2qm74 2933 17 ml ml NN cord-015021-pol2qm74 2933 18 to to IN cord-015021-pol2qm74 2933 19 1 1 CD cord-015021-pol2qm74 2933 20 p_g p_g NNP cord-015021-pol2qm74 2933 21 / / SYM cord-015021-pol2qm74 2933 22 ml ml NN cord-015021-pol2qm74 2933 23 ) ) -RRB- cord-015021-pol2qm74 2933 24 . . . cord-015021-pol2qm74 2934 1 In in IN cord-015021-pol2qm74 2934 2 contrast contrast NN cord-015021-pol2qm74 2934 3 , , , cord-015021-pol2qm74 2934 4 levels level NNS cord-015021-pol2qm74 2934 5 of of IN cord-015021-pol2qm74 2934 6 MIF MIF NNP cord-015021-pol2qm74 2934 7 mRNA mRNA NNP cord-015021-pol2qm74 2934 8 correlated correlate VBD cord-015021-pol2qm74 2934 9 inversely inversely RB cord-015021-pol2qm74 2934 10 with with IN cord-015021-pol2qm74 2934 11 LPS LPS NNP cord-015021-pol2qm74 2934 12 concentration concentration NN cord-015021-pol2qm74 2934 13 . . . cord-015021-pol2qm74 2935 1 By by IN cord-015021-pol2qm74 2935 2 competitive competitive JJ cord-015021-pol2qm74 2935 3 PCR PCR NNP cord-015021-pol2qm74 2935 4 , , , cord-015021-pol2qm74 2935 5 MIF MIF NNP cord-015021-pol2qm74 2935 6 mRNA mRNA NNP cord-015021-pol2qm74 2935 7 was be VBD cord-015021-pol2qm74 2935 8 observed observe VBN cord-015021-pol2qm74 2935 9 to to TO cord-015021-pol2qm74 2935 10 increase increase VB cord-015021-pol2qm74 2935 11 approximately approximately RB cord-015021-pol2qm74 2935 12 2-fold 2-fold CD cord-015021-pol2qm74 2935 13 after after IN cord-015021-pol2qm74 2935 14 LPS LPS NNP cord-015021-pol2qm74 2935 15 induction induction NN cord-015021-pol2qm74 2935 16 ( ( -LRB- cord-015021-pol2qm74 2935 17 100 100 CD cord-015021-pol2qm74 2935 18 pg pg NN cord-015021-pol2qm74 2935 19 / / SYM cord-015021-pol2qm74 2935 20 ml ml NNP cord-015021-pol2qm74 2935 21 ) ) -RRB- cord-015021-pol2qm74 2935 22 . . . cord-015021-pol2qm74 2936 1 MIF MIF NNP cord-015021-pol2qm74 2936 2 secretion secretion NN cord-015021-pol2qm74 2936 3 also also RB cord-015021-pol2qm74 2936 4 was be VBD cord-015021-pol2qm74 2936 5 induced induce VBN cord-015021-pol2qm74 2936 6 by by IN cord-015021-pol2qm74 2936 7 TNFoc TNFoc NNP cord-015021-pol2qm74 2936 8 ( ( -LRB- cord-015021-pol2qm74 2936 9 1 1 CD cord-015021-pol2qm74 2936 10 ng ng NN cord-015021-pol2qm74 2936 11 / / SYM cord-015021-pol2qm74 2936 12 ml ml NN cord-015021-pol2qm74 2936 13 ) ) -RRB- cord-015021-pol2qm74 2936 14 and and CC cord-015021-pol2qm74 2936 15 IFN IFN NNP cord-015021-pol2qm74 2936 16 ? ? . cord-015021-pol2qm74 2937 1 ( ( -LRB- cord-015021-pol2qm74 2937 2 10 10 CD cord-015021-pol2qm74 2937 3 IU IU NNP cord-015021-pol2qm74 2937 4 / / SYM cord-015021-pol2qm74 2937 5 ml ml NN cord-015021-pol2qm74 2937 6 ) ) -RRB- cord-015021-pol2qm74 2937 7 , , , cord-015021-pol2qm74 2937 8 but but CC cord-015021-pol2qm74 2937 9 not not RB cord-015021-pol2qm74 2937 10 by by IN cord-015021-pol2qm74 2938 1 IL-113 IL-113 NNP cord-015021-pol2qm74 2938 2 and and CC cord-015021-pol2qm74 2938 3 IL-6 IL-6 NNP cord-015021-pol2qm74 2938 4 ( ( -LRB- cord-015021-pol2qm74 2938 5 up up IN cord-015021-pol2qm74 2938 6 to to TO cord-015021-pol2qm74 2938 7 10 10 CD cord-015021-pol2qm74 2938 8 ng ng NN cord-015021-pol2qm74 2938 9 / / SYM cord-015021-pol2qm74 2938 10 ml ml NN cord-015021-pol2qm74 2938 11 ) ) -RRB- cord-015021-pol2qm74 2938 12 . . . cord-015021-pol2qm74 2939 1 LPS LPS NNP cord-015021-pol2qm74 2939 2 and and CC cord-015021-pol2qm74 2939 3 IFN IFN NNP cord-015021-pol2qm74 2939 4 7 7 CD cord-015021-pol2qm74 2939 5 had have VBD cord-015021-pol2qm74 2939 6 additive additive NN cord-015021-pol2qm74 2939 7 effects effect NNS cord-015021-pol2qm74 2939 8 in in IN cord-015021-pol2qm74 2939 9 inducing induce VBG cord-015021-pol2qm74 2939 10 MIF MIF NNP cord-015021-pol2qm74 2939 11 secretion secretion NN cord-015021-pol2qm74 2939 12 . . . cord-015021-pol2qm74 2940 1 In in IN cord-015021-pol2qm74 2940 2 separate separate JJ cord-015021-pol2qm74 2940 3 experiments experiment NNS cord-015021-pol2qm74 2940 4 , , , cord-015021-pol2qm74 2940 5 macrophages macrophage NNS cord-015021-pol2qm74 2940 6 stimulated stimulate VBN cord-015021-pol2qm74 2940 7 with with IN cord-015021-pol2qm74 2940 8 recombinant recombinant JJ cord-015021-pol2qm74 2940 9 mouse mouse NN cord-015021-pol2qm74 2940 10 MIF MIF NNP cord-015021-pol2qm74 2940 11 ( ( -LRB- cord-015021-pol2qm74 2940 12 1 1 CD cord-015021-pol2qm74 2940 13 gg gg NNP cord-015021-pol2qm74 2940 14 / / SYM cord-015021-pol2qm74 2940 15 ml ml NN cord-015021-pol2qm74 2940 16 ) ) -RRB- cord-015021-pol2qm74 2940 17 were be VBD cord-015021-pol2qm74 2940 18 found find VBN cord-015021-pol2qm74 2940 19 to to TO cord-015021-pol2qm74 2940 20 secrete secrete VB cord-015021-pol2qm74 2940 21 bioactive bioactive JJ cord-015021-pol2qm74 2940 22 TNF~ tnf~ PRP cord-015021-pol2qm74 2940 23 ( ( -LRB- cord-015021-pol2qm74 2940 24 > > NFP cord-015021-pol2qm74 2940 25 750 750 CD cord-015021-pol2qm74 2940 26 pg pg NN cord-015021-pol2qm74 2940 27 / / SYM cord-015021-pol2qm74 2940 28 ml ml NNS cord-015021-pol2qm74 2940 29 by by IN cord-015021-pol2qm74 2940 30 L929 l929 CD cord-015021-pol2qm74 2940 31 cytotoxicity cytotoxicity NN cord-015021-pol2qm74 2940 32 ) ) -RRB- cord-015021-pol2qm74 2940 33 . . . cord-015021-pol2qm74 2941 1 We -PRON- PRP cord-015021-pol2qm74 2941 2 conclude conclude VBP cord-015021-pol2qm74 2941 3 that that IN cord-015021-pol2qm74 2941 4 the the DT cord-015021-pol2qm74 2941 5 macrophage macrophage NN cord-015021-pol2qm74 2941 6 is be VBZ cord-015021-pol2qm74 2941 7 an an DT cord-015021-pol2qm74 2941 8 important important JJ cord-015021-pol2qm74 2941 9 albeit albeit IN cord-015021-pol2qm74 2941 10 overlooked overlook VBN cord-015021-pol2qm74 2941 11 cellular cellular JJ cord-015021-pol2qm74 2941 12 source source NN cord-015021-pol2qm74 2941 13 of of IN cord-015021-pol2qm74 2941 14 MIF MIF NNP cord-015021-pol2qm74 2941 15 in in IN cord-015021-pol2qm74 2941 16 vivo vivo NNP cord-015021-pol2qm74 2941 17 . . . cord-015021-pol2qm74 2942 1 MIF MIF NNP cord-015021-pol2qm74 2942 2 secretion secretion NN cord-015021-pol2qm74 2942 3 is be VBZ cord-015021-pol2qm74 2942 4 induced induce VBN cord-015021-pol2qm74 2942 5 by by IN cord-015021-pol2qm74 2942 6 LPS LPS NNP cord-015021-pol2qm74 2942 7 , , , cord-015021-pol2qm74 2942 8 TNFc~ TNFc~ NNP cord-015021-pol2qm74 2942 9 and and CC cord-015021-pol2qm74 2942 10 IFN IFN NNP cord-015021-pol2qm74 2942 11 ? ? . cord-015021-pol2qm74 2942 12 . . . cord-015021-pol2qm74 2943 1 MIF MIF NNP cord-015021-pol2qm74 2943 2 also also RB cord-015021-pol2qm74 2943 3 stimulates stimulate VBZ cord-015021-pol2qm74 2943 4 macrophages macrophage NNS cord-015021-pol2qm74 2943 5 to to TO cord-015021-pol2qm74 2943 6 secrete secrete VB cord-015021-pol2qm74 2943 7 TNF TNF NNP cord-015021-pol2qm74 2943 8 . . . cord-015021-pol2qm74 2944 1 Taken take VBN cord-015021-pol2qm74 2944 2 together together RB cord-015021-pol2qm74 2944 3 with with IN cord-015021-pol2qm74 2944 4 previous previous JJ cord-015021-pol2qm74 2944 5 observations observation NNS cord-015021-pol2qm74 2944 6 that that IN cord-015021-pol2qm74 2944 7 anti anti JJ cord-015021-pol2qm74 2944 8 - - JJ cord-015021-pol2qm74 2944 9 MIF mif JJ cord-015021-pol2qm74 2944 10 antibody antibody NN cord-015021-pol2qm74 2944 11 protects protect VBZ cord-015021-pol2qm74 2944 12 against against IN cord-015021-pol2qm74 2944 13 lethal lethal JJ cord-015021-pol2qm74 2944 14 endotoxemia endotoxemia NN cord-015021-pol2qm74 2944 15 , , , cord-015021-pol2qm74 2944 16 these these DT cord-015021-pol2qm74 2944 17 data datum NNS cord-015021-pol2qm74 2944 18 implicate implicate VBP cord-015021-pol2qm74 2944 19 MIF MIF NNP cord-015021-pol2qm74 2944 20 as as IN cord-015021-pol2qm74 2944 21 a a DT cord-015021-pol2qm74 2944 22 critical critical JJ cord-015021-pol2qm74 2944 23 mediator mediator NN cord-015021-pol2qm74 2944 24 of of IN cord-015021-pol2qm74 2944 25 inflammation inflammation NN cord-015021-pol2qm74 2944 26 and and CC cord-015021-pol2qm74 2944 27 septic septic JJ cord-015021-pol2qm74 2944 28 shock shock NN cord-015021-pol2qm74 2944 29 . . . cord-015021-pol2qm74 2945 1 Inflammation inflammation NN cord-015021-pol2qm74 2945 2 is be VBZ cord-015021-pol2qm74 2945 3 characterized characterize VBN cord-015021-pol2qm74 2945 4 by by IN cord-015021-pol2qm74 2945 5 an an DT cord-015021-pol2qm74 2945 6 exacerbation exacerbation NN cord-015021-pol2qm74 2945 7 of of IN cord-015021-pol2qm74 2945 8 proinflammatory proinflammatory JJ cord-015021-pol2qm74 2945 9 cytokine cytokine NN cord-015021-pol2qm74 2945 10 production production NN cord-015021-pol2qm74 2945 11 . . . cord-015021-pol2qm74 2946 1 Cytokines cytokine NNS cord-015021-pol2qm74 2946 2 such such JJ cord-015021-pol2qm74 2946 3 as as IN cord-015021-pol2qm74 2946 4 IL-4 IL-4 NNP cord-015021-pol2qm74 2946 5 , , , cord-015021-pol2qm74 2946 6 IL-10 IL-10 NNP cord-015021-pol2qm74 2946 7 , , , cord-015021-pol2qm74 2946 8 and and CC cord-015021-pol2qm74 2946 9 TGF8 TGF8 NNP cord-015021-pol2qm74 2946 10 , , , cord-015021-pol2qm74 2946 11 have have VBP cord-015021-pol2qm74 2946 12 been be VBN cord-015021-pol2qm74 2946 13 identified identify VBN cord-015021-pol2qm74 2946 14 as as IN cord-015021-pol2qm74 2946 15 anti anti JJ cord-015021-pol2qm74 2946 16 - - JJ cord-015021-pol2qm74 2946 17 inflammatory inflammatory JJ cord-015021-pol2qm74 2946 18 mediators mediator NNS cord-015021-pol2qm74 2946 19 thanks thank NNS cord-015021-pol2qm74 2946 20 to to IN cord-015021-pol2qm74 2946 21 their -PRON- PRP$ cord-015021-pol2qm74 2946 22 ability ability NN cord-015021-pol2qm74 2946 23 to to TO cord-015021-pol2qm74 2946 24 down down RB cord-015021-pol2qm74 2946 25 regulate regulate VB cord-015021-pol2qm74 2946 26 the the DT cord-015021-pol2qm74 2946 27 production production NN cord-015021-pol2qm74 2946 28 of of IN cord-015021-pol2qm74 2946 29 IL-1 IL-1 NNP cord-015021-pol2qm74 2946 30 , , , cord-015021-pol2qm74 2946 31 IL-6 IL-6 NNP cord-015021-pol2qm74 2946 32 , , , cord-015021-pol2qm74 2947 1 IL-8 IL-8 NNP cord-015021-pol2qm74 2947 2 , , , cord-015021-pol2qm74 2947 3 TNFc~ TNFc~ NNP cord-015021-pol2qm74 2947 4 by by IN cord-015021-pol2qm74 2947 5 activated activate VBN cord-015021-pol2qm74 2947 6 monocytes monocyte NNS cord-015021-pol2qm74 2947 7 / / SYM cord-015021-pol2qm74 2947 8 macrophages macrophage NNS cord-015021-pol2qm74 2947 9 . . . cord-015021-pol2qm74 2948 1 However however RB cord-015021-pol2qm74 2948 2 , , , cord-015021-pol2qm74 2948 3 other other JJ cord-015021-pol2qm74 2948 4 cells cell NNS cord-015021-pol2qm74 2948 5 , , , cord-015021-pol2qm74 2948 6 including include VBG cord-015021-pol2qm74 2948 7 polymorphonuclear polymorphonuclear NN cord-015021-pol2qm74 2948 8 cells cell NNS cord-015021-pol2qm74 2948 9 ( ( -LRB- cord-015021-pol2qm74 2948 10 PMN pmn NN cord-015021-pol2qm74 2948 11 ) ) -RRB- cord-015021-pol2qm74 2948 12 do do VBP cord-015021-pol2qm74 2948 13 contribute contribute VB cord-015021-pol2qm74 2948 14 to to IN cord-015021-pol2qm74 2948 15 the the DT cord-015021-pol2qm74 2948 16 release release NN cord-015021-pol2qm74 2948 17 of of IN cord-015021-pol2qm74 2948 18 pro pro JJ cord-015021-pol2qm74 2948 19 - - JJ cord-015021-pol2qm74 2948 20 inflammatory inflammatory JJ cord-015021-pol2qm74 2948 21 cytokines cytokine NNS cord-015021-pol2qm74 2948 22 . . . cord-015021-pol2qm74 2949 1 We -PRON- PRP cord-015021-pol2qm74 2949 2 investigated investigate VBD cord-015021-pol2qm74 2949 3 the the DT cord-015021-pol2qm74 2949 4 capacity capacity NN cord-015021-pol2qm74 2949 5 of of IN cord-015021-pol2qm74 2949 6 the the DT cord-015021-pol2qm74 2949 7 so so RB cord-015021-pol2qm74 2949 8 - - HYPH cord-015021-pol2qm74 2949 9 called call VBN cord-015021-pol2qm74 2949 10 anti anti JJ cord-015021-pol2qm74 2949 11 - - JJ cord-015021-pol2qm74 2949 12 inflammatory inflammatory JJ cord-015021-pol2qm74 2949 13 cytokines cytokine NNS cord-015021-pol2qm74 2949 14 to to TO cord-015021-pol2qm74 2949 15 control control VB cord-015021-pol2qm74 2949 16 the the DT cord-015021-pol2qm74 2949 17 release release NN cord-015021-pol2qm74 2949 18 of of IN cord-015021-pol2qm74 2949 19 IL-8 IL-8 NNP cord-015021-pol2qm74 2949 20 by by IN cord-015021-pol2qm74 2949 21 activated activate VBN cord-015021-pol2qm74 2949 22 neutrophils neutrophil NNS cord-015021-pol2qm74 2949 23 . . . cord-015021-pol2qm74 2950 1 Human Human NNP cord-015021-pol2qm74 2950 2 PMN PMN NNP cord-015021-pol2qm74 2950 3 were be VBD cord-015021-pol2qm74 2950 4 purified purify VBN cord-015021-pol2qm74 2950 5 following follow VBG cord-015021-pol2qm74 2950 6 glucose glucose NN cord-015021-pol2qm74 2950 7 - - HYPH cord-015021-pol2qm74 2950 8 dextran dextran NN cord-015021-pol2qm74 2950 9 sedimentation sedimentation NN cord-015021-pol2qm74 2950 10 and and CC cord-015021-pol2qm74 2950 11 FicolI ficoli RB cord-015021-pol2qm74 2950 12 - - HYPH cord-015021-pol2qm74 2950 13 Hypaque hypaque NN cord-015021-pol2qm74 2950 14 centrifugation centrifugation NN cord-015021-pol2qm74 2950 15 . . . cord-015021-pol2qm74 2951 1 The the DT cord-015021-pol2qm74 2951 2 cells cell NNS cord-015021-pol2qm74 2951 3 were be VBD cord-015021-pol2qm74 2951 4 cultured culture VBN cord-015021-pol2qm74 2951 5 at at IN cord-015021-pol2qm74 2951 6 37 37 CD cord-015021-pol2qm74 2951 7 ° ° NN cord-015021-pol2qm74 2951 8 C c NN cord-015021-pol2qm74 2951 9 for for IN cord-015021-pol2qm74 2951 10 24h 24h NNS cord-015021-pol2qm74 2951 11 in in IN cord-015021-pol2qm74 2951 12 the the DT cord-015021-pol2qm74 2951 13 absence absence NN cord-015021-pol2qm74 2951 14 or or CC cord-015021-pol2qm74 2951 15 presence presence NN cord-015021-pol2qm74 2951 16 of of IN cord-015021-pol2qm74 2951 17 lipopolysaccharide lipopolysaccharide NN cord-015021-pol2qm74 2951 18 ( ( -LRB- cord-015021-pol2qm74 2951 19 LPS LPS NNP cord-015021-pol2qm74 2951 20 ) ) -RRB- cord-015021-pol2qm74 2951 21 or or CC cord-015021-pol2qm74 2951 22 TNFa TNFa NNS cord-015021-pol2qm74 2951 23 . . . cord-015021-pol2qm74 2952 1 IL-8 IL-8 NNP cord-015021-pol2qm74 2952 2 release release NN cord-015021-pol2qm74 2952 3 was be VBD cord-015021-pol2qm74 2952 4 measured measure VBN cord-015021-pol2qm74 2952 5 in in IN cord-015021-pol2qm74 2952 6 the the DT cord-015021-pol2qm74 2952 7 supernatants supernatant NNS cord-015021-pol2qm74 2952 8 using use VBG cord-015021-pol2qm74 2952 9 a a DT cord-015021-pol2qm74 2952 10 specific specific JJ cord-015021-pol2qm74 2952 11 ELISA ELISA NNP cord-015021-pol2qm74 2952 12 . . . cord-015021-pol2qm74 2953 1 Among among IN cord-015021-pol2qm74 2953 2 tested test VBN cord-015021-pol2qm74 2953 3 cytokines cytokine NNS cord-015021-pol2qm74 2953 4 , , , cord-015021-pol2qm74 2953 5 IL-10 IL-10 NNP cord-015021-pol2qm74 2953 6 was be VBD cord-015021-pol2qm74 2953 7 the the DT cord-015021-pol2qm74 2953 8 most most RBS cord-015021-pol2qm74 2953 9 efficient efficient JJ cord-015021-pol2qm74 2953 10 inhibitor inhibitor NN cord-015021-pol2qm74 2953 11 of of IN cord-015021-pol2qm74 2953 12 IL-8 IL-8 NNP cord-015021-pol2qm74 2953 13 production production NN cord-015021-pol2qm74 2953 14 by by IN cord-015021-pol2qm74 2953 15 LPS LPS NNP cord-015021-pol2qm74 2953 16 - - HYPH cord-015021-pol2qm74 2953 17 activated activate VBN cord-015021-pol2qm74 2953 18 PMN PMN NNP cord-015021-pol2qm74 2953 19 . . . cord-015021-pol2qm74 2954 1 IL-4 IL-4 NNP cord-015021-pol2qm74 2954 2 was be VBD cord-015021-pol2qm74 2954 3 also also RB cord-015021-pol2qm74 2954 4 active active JJ cord-015021-pol2qm74 2954 5 , , , cord-015021-pol2qm74 2954 6 whereas whereas IN cord-015021-pol2qm74 2954 7 no no DT cord-015021-pol2qm74 2954 8 down down JJ cord-015021-pol2qm74 2954 9 regulation regulation NN cord-015021-pol2qm74 2954 10 was be VBD cord-015021-pol2qm74 2954 11 noticed notice VBN cord-015021-pol2qm74 2954 12 with with IN cord-015021-pol2qm74 2954 13 TGFP TGFP NNP cord-015021-pol2qm74 2954 14 ~ ~ NFP cord-015021-pol2qm74 2954 15 I. i. NN cord-015021-pol2qm74 2955 1 When when WRB cord-015021-pol2qm74 2955 2 TNFa TNFa NNP cord-015021-pol2qm74 2955 3 was be VBD cord-015021-pol2qm74 2955 4 used use VBN cord-015021-pol2qm74 2955 5 as as IN cord-015021-pol2qm74 2955 6 a a DT cord-015021-pol2qm74 2955 7 triggering trigger VBG cord-015021-pol2qm74 2955 8 agent agent NN cord-015021-pol2qm74 2955 9 , , , cord-015021-pol2qm74 2955 10 none none NN cord-015021-pol2qm74 2955 11 of of IN cord-015021-pol2qm74 2955 12 the the DT cord-015021-pol2qm74 2955 13 cytokine cytokine NN cord-015021-pol2qm74 2955 14 could could MD cord-015021-pol2qm74 2955 15 prevent prevent VB cord-015021-pol2qm74 2955 16 IL-8 il-8 NN cord-015021-pol2qm74 2955 17 production production NN cord-015021-pol2qm74 2955 18 . . . cord-015021-pol2qm74 2956 1 Northern northern JJ cord-015021-pol2qm74 2956 2 analysis analysis NN cord-015021-pol2qm74 2956 3 are be VBP cord-015021-pol2qm74 2956 4 under under IN cord-015021-pol2qm74 2956 5 investigation investigation NN cord-015021-pol2qm74 2956 6 to to TO cord-015021-pol2qm74 2956 7 precise precise VB cord-015021-pol2qm74 2956 8 the the DT cord-015021-pol2qm74 2956 9 level level NN cord-015021-pol2qm74 2956 10 of of IN cord-015021-pol2qm74 2956 11 the the DT cord-015021-pol2qm74 2956 12 IL-4-and IL-4-and NNP cord-015021-pol2qm74 2956 13 IL-10-induced il-10-induced JJ cord-015021-pol2qm74 2956 14 inhibition inhibition NN cord-015021-pol2qm74 2956 15 of of IN cord-015021-pol2qm74 2956 16 IL-8 il-8 NN cord-015021-pol2qm74 2956 17 production production NN cord-015021-pol2qm74 2956 18 by by IN cord-015021-pol2qm74 2956 19 PMN PMN NNP cord-015021-pol2qm74 2956 20 . . . cord-015021-pol2qm74 2957 1 Our -PRON- PRP$ cord-015021-pol2qm74 2957 2 data datum NNS cord-015021-pol2qm74 2957 3 illustrate illustrate VBP cord-015021-pol2qm74 2957 4 that that IN cord-015021-pol2qm74 2957 5 IL-10 IL-10 NNP cord-015021-pol2qm74 2957 6 and and CC cord-015021-pol2qm74 2957 7 IL-4 IL-4 NNP cord-015021-pol2qm74 2957 8 possess possess VBP cord-015021-pol2qm74 2957 9 the the DT cord-015021-pol2qm74 2957 10 capacity capacity NN cord-015021-pol2qm74 2957 11 to to TO cord-015021-pol2qm74 2957 12 down down RB cord-015021-pol2qm74 2957 13 regulate regulate VB cord-015021-pol2qm74 2957 14 the the DT cord-015021-pol2qm74 2957 15 production production NN cord-015021-pol2qm74 2957 16 of of IN cord-015021-pol2qm74 2957 17 IL-8 IL-8 NNP cord-015021-pol2qm74 2957 18 by by IN cord-015021-pol2qm74 2957 19 both both DT cord-015021-pol2qm74 2957 20 monocytes monocyte NNS cord-015021-pol2qm74 2957 21 and and CC cord-015021-pol2qm74 2957 22 PMN PMN NNP cord-015021-pol2qm74 2957 23 , , , cord-015021-pol2qm74 2957 24 whereas whereas IN cord-015021-pol2qm74 2957 25 TGFB TGFB NNP cord-015021-pol2qm74 2957 26 has have VBZ cord-015021-pol2qm74 2957 27 a a DT cord-015021-pol2qm74 2957 28 more more RBR cord-015021-pol2qm74 2957 29 limited limited JJ cord-015021-pol2qm74 2957 30 inhibitory inhibitory JJ cord-015021-pol2qm74 2957 31 activity activity NN cord-015021-pol2qm74 2957 32 . . . cord-015021-pol2qm74 2958 1 Ciliary ciliary JJ cord-015021-pol2qm74 2958 2 neurotrophic neurotrophic NN cord-015021-pol2qm74 2958 3 factor factor NN cord-015021-pol2qm74 2958 4 ( ( -LRB- cord-015021-pol2qm74 2958 5 CNTF CNTF NNP cord-015021-pol2qm74 2958 6 ) ) -RRB- cord-015021-pol2qm74 2958 7 , , , cord-015021-pol2qm74 2958 8 a a DT cord-015021-pol2qm74 2958 9 member member NN cord-015021-pol2qm74 2958 10 of of IN cord-015021-pol2qm74 2958 11 the the DT cord-015021-pol2qm74 2958 12 IL-6 IL-6 NNP cord-015021-pol2qm74 2958 13 superfamily superfamily NN cord-015021-pol2qm74 2958 14 , , , cord-015021-pol2qm74 2958 15 has have VBZ cord-015021-pol2qm74 2958 16 recently recently RB cord-015021-pol2qm74 2958 17 been be VBN cord-015021-pol2qm74 2958 18 shown show VBN cord-015021-pol2qm74 2958 19 to to TO cord-015021-pol2qm74 2958 20 promote promote VB cord-015021-pol2qm74 2958 21 axonal axonal JJ cord-015021-pol2qm74 2958 22 growth growth NN cord-015021-pol2qm74 2958 23 and and CC cord-015021-pol2qm74 2958 24 neuronal neuronal JJ cord-015021-pol2qm74 2958 25 healing healing NN cord-015021-pol2qm74 2958 26 . . . cord-015021-pol2qm74 2959 1 CNTF cntf NN cord-015021-pol2qm74 2959 2 production production NN cord-015021-pol2qm74 2959 3 is be VBZ cord-015021-pol2qm74 2959 4 also also RB cord-015021-pol2qm74 2959 5 increased increase VBN cord-015021-pol2qm74 2959 6 during during IN cord-015021-pol2qm74 2959 7 neuronal neuronal JJ cord-015021-pol2qm74 2959 8 and and CC cord-015021-pol2qm74 2959 9 muscle muscle NN cord-015021-pol2qm74 2959 10 damage damage NN cord-015021-pol2qm74 2959 11 , , , cord-015021-pol2qm74 2959 12 associated associate VBN cord-015021-pol2qm74 2959 13 with with IN cord-015021-pol2qm74 2959 14 soft soft JJ cord-015021-pol2qm74 2959 15 tissue tissue NN cord-015021-pol2qm74 2959 16 injury injury NN cord-015021-pol2qm74 2959 17 or or CC cord-015021-pol2qm74 2959 18 trauma trauma NN cord-015021-pol2qm74 2959 19 . . . cord-015021-pol2qm74 2960 1 We -PRON- PRP cord-015021-pol2qm74 2960 2 postulated postulate VBD cord-015021-pol2qm74 2960 3 that that IN cord-015021-pol2qm74 2960 4 production production NN cord-015021-pol2qm74 2960 5 of of IN cord-015021-pol2qm74 2960 6 CNTF CNTF NNP cord-015021-pol2qm74 2960 7 may may MD cord-015021-pol2qm74 2960 8 explain explain VB cord-015021-pol2qm74 2960 9 the the DT cord-015021-pol2qm74 2960 10 loss loss NN cord-015021-pol2qm74 2960 11 of of IN cord-015021-pol2qm74 2960 12 skeletal skeletal JJ cord-015021-pol2qm74 2960 13 muscM muscM NNP cord-015021-pol2qm74 2960 14 protein protein NN cord-015021-pol2qm74 2960 15 that that WDT cord-015021-pol2qm74 2960 16 occurs occur VBZ cord-015021-pol2qm74 2960 17 in in IN cord-015021-pol2qm74 2960 18 inflammation inflammation NN cord-015021-pol2qm74 2960 19 . . . cord-015021-pol2qm74 2961 1 40 40 CD cord-015021-pol2qm74 2961 2 female female NN cord-015021-pol2qm74 2961 3 , , , cord-015021-pol2qm74 2961 4 Wistar Wistar NNP cord-015021-pol2qm74 2961 5 ( ( -LRB- cord-015021-pol2qm74 2961 6 175 175 CD cord-015021-pol2qm74 2961 7 - - SYM cord-015021-pol2qm74 2961 8 200 200 CD cord-015021-pol2qm74 2961 9 gm gm NNP cord-015021-pol2qm74 2961 10 ) ) -RRB- cord-015021-pol2qm74 2961 11 rats rat NNS cord-015021-pol2qm74 2961 12 received receive VBD cord-015021-pol2qm74 2961 13 either either CC cord-015021-pol2qm74 2961 14 250 250 CD cord-015021-pol2qm74 2961 15 or or CC cord-015021-pol2qm74 2961 16 25 25 CD cord-015021-pol2qm74 2961 17 pg pg NN cord-015021-pol2qm74 2961 18 / / SYM cord-015021-pol2qm74 2961 19 kg kg NNP cord-015021-pol2qm74 2961 20 BW BW NNP cord-015021-pol2qm74 2961 21 s.c s.c NNP cord-015021-pol2qm74 2961 22 . . . cord-015021-pol2qm74 2961 23 injections injection NNS cord-015021-pol2qm74 2961 24 of of IN cord-015021-pol2qm74 2961 25 recombinant recombinant JJ cord-015021-pol2qm74 2961 26 rat rat NN cord-015021-pol2qm74 2961 27 CNTF CNTF NNP cord-015021-pol2qm74 2961 28 for for IN cord-015021-pol2qm74 2961 29 seven seven CD cord-015021-pol2qm74 2961 30 days day NNS cord-015021-pol2qm74 2961 31 , , , cord-015021-pol2qm74 2961 32 or or CC cord-015021-pol2qm74 2961 33 received receive VBD cord-015021-pol2qm74 2961 34 sham sham JJ cord-015021-pol2qm74 2961 35 injections injection NNS cord-015021-pol2qm74 2961 36 and and CC cord-015021-pol2qm74 2961 37 were be VBD cord-015021-pol2qm74 2961 38 freely freely RB cord-015021-pol2qm74 2961 39 - - HYPH cord-015021-pol2qm74 2961 40 fed feed VBN cord-015021-pol2qm74 2961 41 . . . cord-015021-pol2qm74 2962 1 Additional additional JJ cord-015021-pol2qm74 2962 2 animals animal NNS cord-015021-pol2qm74 2962 3 were be VBD cord-015021-pol2qm74 2962 4 pretreated pretreate VBN cord-015021-pol2qm74 2962 5 with with IN cord-015021-pol2qm74 2962 6 10 10 CD cord-015021-pol2qm74 2962 7 mg mg NNP cord-015021-pol2qm74 2962 8 / / SYM cord-015021-pol2qm74 2962 9 kg kg NNP cord-015021-pol2qm74 2962 10 ibuprofen ibuprofen NNP cord-015021-pol2qm74 2962 11 Lp Lp NNP cord-015021-pol2qm74 2962 12 prior prior RB cord-015021-pol2qm74 2962 13 to to IN cord-015021-pol2qm74 2962 14 250 250 CD cord-015021-pol2qm74 2962 15 pg pg NN cord-015021-pol2qm74 2962 16 / / SYM cord-015021-pol2qm74 2962 17 kg kg NNP cord-015021-pol2qm74 2962 18 BW BW NNP cord-015021-pol2qm74 2962 19 CNTF CNTF NNP cord-015021-pol2qm74 2962 20 . . . cord-015021-pol2qm74 2963 1 Rats rat NNS cord-015021-pol2qm74 2963 2 treated treat VBN cord-015021-pol2qm74 2963 3 with with IN cord-015021-pol2qm74 2963 4 250 250 CD cord-015021-pol2qm74 2963 5 , , , cord-015021-pol2qm74 2963 6 ug ug NNP cord-015021-pol2qm74 2963 7 / / SYM cord-015021-pol2qm74 2963 8 kg kg NNP cord-015021-pol2qm74 2963 9 BW BW NNP cord-015021-pol2qm74 2963 10 CNTF CNTF NNP cord-015021-pol2qm74 2963 11 lost lose VBD cord-015021-pol2qm74 2963 12 6.8_+0.4 6.8_+0.4 CD cord-015021-pol2qm74 2963 13 gms gms NNP cord-015021-pol2qm74 2963 14 BW BW NNP cord-015021-pol2qm74 2963 15 as as IN cord-015021-pol2qm74 2963 16 compared compare VBN cord-015021-pol2qm74 2963 17 to to IN cord-015021-pol2qm74 2963 18 freely freely RB cord-015021-pol2qm74 2963 19 - - HYPH cord-015021-pol2qm74 2963 20 fed feed VBN cord-015021-pol2qm74 2963 21 controls control NNS cord-015021-pol2qm74 2963 22 which which WDT cord-015021-pol2qm74 2963 23 gained gain VBD cord-015021-pol2qm74 2963 24 17.0_+3.1 17.0_+3.1 CD cord-015021-pol2qm74 2963 25 gms gms NNP cord-015021-pol2qm74 2963 26 ( ( -LRB- cord-015021-pol2qm74 2963 27 p p NN cord-015021-pol2qm74 2963 28 < < XX cord-015021-pol2qm74 2963 29 O.001 o.001 XX cord-015021-pol2qm74 2963 30 by by IN cord-015021-pol2qm74 2963 31 ANOVA ANOVA NNP cord-015021-pol2qm74 2963 32 and and CC cord-015021-pol2qm74 2963 33 LSD LSD NNP cord-015021-pol2qm74 2963 34 ) ) -RRB- cord-015021-pol2qm74 2963 35 , , , cord-015021-pol2qm74 2963 36 and and CC cord-015021-pol2qm74 2963 37 ibuprofen ibuprofen NN cord-015021-pol2qm74 2963 38 treatment treatment NN cord-015021-pol2qm74 2963 39 had have VBD cord-015021-pol2qm74 2963 40 no no DT cord-015021-pol2qm74 2963 41 effect effect NN cord-015021-pol2qm74 2963 42 on on IN cord-015021-pol2qm74 2963 43 CNTF CNTF NNP cord-015021-pol2qm74 2963 44 - - HYPH cord-015021-pol2qm74 2963 45 induced induce VBN cord-015021-pol2qm74 2963 46 weight weight NN cord-015021-pol2qm74 2963 47 loss loss NN cord-015021-pol2qm74 2963 48 ( ( -LRB- cord-015021-pol2qm74 2963 49 -5.8_+0.7 -5.8_+0.7 NN cord-015021-pol2qm74 2963 50 ) ) -RRB- cord-015021-pol2qm74 2963 51 . . . cord-015021-pol2qm74 2964 1 Animals animal NNS cord-015021-pol2qm74 2964 2 pair pair VBP cord-015021-pol2qm74 2964 3 fed feed VBN cord-015021-pol2qm74 2964 4 to to IN cord-015021-pol2qm74 2964 5 the the DT cord-015021-pol2qm74 2964 6 high high JJ cord-015021-pol2qm74 2964 7 dose dose NN cord-015021-pol2qm74 2965 1 CNTF CNTF NNP cord-015021-pol2qm74 2965 2 gained gain VBD cord-015021-pol2qm74 2965 3 body body NN cord-015021-pol2qm74 2965 4 weight weight NN cord-015021-pol2qm74 2965 5 ( ( -LRB- cord-015021-pol2qm74 2965 6 10.2-+3.5 10.2-+3.5 CD cord-015021-pol2qm74 2965 7 ) ) -RRB- cord-015021-pol2qm74 2965 8 , , , cord-015021-pol2qm74 2965 9 although although IN cord-015021-pol2qm74 2965 10 weight weight NN cord-015021-pol2qm74 2965 11 gain gain NN cord-015021-pol2qm74 2965 12 was be VBD cord-015021-pol2qm74 2965 13 less less JJR cord-015021-pol2qm74 2965 14 than than IN cord-015021-pol2qm74 2965 15 seen see VBN cord-015021-pol2qm74 2965 16 in in IN cord-015021-pol2qm74 2965 17 freely freely RB cord-015021-pol2qm74 2965 18 - - HYPH cord-015021-pol2qm74 2965 19 fed feed VBN cord-015021-pol2qm74 2965 20 controls control NNS cord-015021-pol2qm74 2965 21 . . . cord-015021-pol2qm74 2966 1 Rats rat NNS cord-015021-pol2qm74 2966 2 treated treat VBN cord-015021-pol2qm74 2966 3 with with IN cord-015021-pol2qm74 2966 4 25 25 CD cord-015021-pol2qm74 2966 5 pg pg NN cord-015021-pol2qm74 2966 6 / / SYM cord-015021-pol2qm74 2966 7 kg kg NNP cord-015021-pol2qm74 2967 1 BW BW NNP cord-015021-pol2qm74 2967 2 had have VBD cord-015021-pol2qm74 2967 3 reduced reduce VBN cord-015021-pol2qm74 2967 4 body body NN cord-015021-pol2qm74 2967 5 weight weight NN cord-015021-pol2qm74 2967 6 gain gain NN cord-015021-pol2qm74 2967 7 ( ( -LRB- cord-015021-pol2qm74 2967 8 +7.8+_4.4 +7.8+_4.4 NFP cord-015021-pol2qm74 2967 9 gin gin NN cord-015021-pol2qm74 2967 10 ) ) -RRB- cord-015021-pol2qm74 2967 11 . . . cord-015021-pol2qm74 2968 1 Food food NN cord-015021-pol2qm74 2968 2 intake intake NN cord-015021-pol2qm74 2968 3 was be VBD cord-015021-pol2qm74 2968 4 also also RB cord-015021-pol2qm74 2968 5 reduced reduce VBN cord-015021-pol2qm74 2968 6 by by IN cord-015021-pol2qm74 2968 7 29 29 CD cord-015021-pol2qm74 2968 8 % % NN cord-015021-pol2qm74 2968 9 in in IN cord-015021-pol2qm74 2968 10 250 250 CD cord-015021-pol2qm74 2968 11 pg pg NN cord-015021-pol2qm74 2968 12 / / SYM cord-015021-pol2qm74 2968 13 kg kg NNP cord-015021-pol2qm74 2968 14 CNTF CNTF NNP cord-015021-pol2qm74 2968 15 ( ( -LRB- cord-015021-pol2qm74 2968 16 from from IN cord-015021-pol2qm74 2968 17 23.7+_0.7 23.7+_0.7 CD cord-015021-pol2qm74 2968 18 gm gm NNP cord-015021-pol2qm74 2968 19 / / SYM cord-015021-pol2qm74 2968 20 day day NN cord-015021-pol2qm74 2968 21 to to IN cord-015021-pol2qm74 2968 22 16.8_+0.6 16.8_+0.6 CD cord-015021-pol2qm74 2968 23 gm gm NNP cord-015021-pol2qm74 2968 24 / / SYM cord-015021-pol2qm74 2968 25 day day NN cord-015021-pol2qm74 2968 26 ; ; : cord-015021-pol2qm74 2968 27 p p NN cord-015021-pol2qm74 2968 28 < < XX cord-015021-pol2qm74 2968 29 O.05 o.05 NN cord-015021-pol2qm74 2968 30 ) ) -RRB- cord-015021-pol2qm74 2968 31 and and CC cord-015021-pol2qm74 2968 32 was be VBD cord-015021-pol2qm74 2968 33 also also RB cord-015021-pol2qm74 2968 34 unaffected unaffected JJ cord-015021-pol2qm74 2968 35 by by IN cord-015021-pol2qm74 2968 36 prior prior JJ cord-015021-pol2qm74 2968 37 ibuprofen ibuprofen NN cord-015021-pol2qm74 2968 38 treatment treatment NN cord-015021-pol2qm74 2968 39 ( ( -LRB- cord-015021-pol2qm74 2968 40 18.4 18.4 CD cord-015021-pol2qm74 2968 41 + + SYM cord-015021-pol2qm74 2968 42 -0.6 -0.6 CD cord-015021-pol2qm74 2968 43 gm gm NNP cord-015021-pol2qm74 2968 44 / / SYM cord-015021-pol2qm74 2968 45 day day NN cord-015021-pol2qm74 2968 46 ) ) -RRB- cord-015021-pol2qm74 2968 47 . . . cord-015021-pol2qm74 2969 1 Despite despite IN cord-015021-pol2qm74 2969 2 the the DT cord-015021-pol2qm74 2969 3 loss loss NN cord-015021-pol2qm74 2969 4 in in IN cord-015021-pol2qm74 2969 5 body body NN cord-015021-pol2qm74 2969 6 weight weight NN cord-015021-pol2qm74 2969 7 noted note VBN cord-015021-pol2qm74 2969 8 in in IN cord-015021-pol2qm74 2969 9 the the DT cord-015021-pol2qm74 2969 10 high high JJ cord-015021-pol2qm74 2969 11 dose dose NN cord-015021-pol2qm74 2969 12 CNTF CNTF NNP cord-015021-pol2qm74 2969 13 animals animal NNS cord-015021-pol2qm74 2969 14 , , , cord-015021-pol2qm74 2969 15 there there EX cord-015021-pol2qm74 2969 16 was be VBD cord-015021-pol2qm74 2969 17 no no DT cord-015021-pol2qm74 2969 18 appreciable appreciable JJ cord-015021-pol2qm74 2969 19 hepatic hepatic JJ cord-015021-pol2qm74 2969 20 acute acute JJ cord-015021-pol2qm74 2969 21 phase phase NN cord-015021-pol2qm74 2969 22 response response NN cord-015021-pol2qm74 2969 23 , , , cord-015021-pol2qm74 2969 24 since since IN cord-015021-pol2qm74 2969 25 liver liver NN cord-015021-pol2qm74 2969 26 weight weight NN cord-015021-pol2qm74 2969 27 ( ( -LRB- cord-015021-pol2qm74 2969 28 8.6 8.6 CD cord-015021-pol2qm74 2969 29 + + SYM cord-015021-pol2qm74 2969 30 0,1 0,1 CD cord-015021-pol2qm74 2969 31 gms gms NN cord-015021-pol2qm74 2969 32 vs. vs. FW cord-015021-pol2qm74 2969 33 9.4_+0.3 9.4_+0.3 CD cord-015021-pol2qm74 2969 34 gins gin NNS cord-015021-pol2qm74 2969 35 ) ) -RRB- cord-015021-pol2qm74 2969 36 , , , cord-015021-pol2qm74 2969 37 total total JJ cord-015021-pol2qm74 2969 38 protein protein NN cord-015021-pol2qm74 2969 39 ( ( -LRB- cord-015021-pol2qm74 2969 40 54.5 54.5 CD cord-015021-pol2qm74 2969 41 + + SYM cord-015021-pol2qm74 2969 42 -2.9 -2.9 CD cord-015021-pol2qm74 2969 43 gms gms NNP cord-015021-pol2qm74 2969 44 / / SYM cord-015021-pol2qm74 2969 45 L l NN cord-015021-pol2qm74 2969 46 vs vs IN cord-015021-pol2qm74 2969 47 44.8 44.8 CD cord-015021-pol2qm74 2969 48 + + CC cord-015021-pol2qm74 2969 49 -3.6 -3.6 NNP cord-015021-pol2qm74 2969 50 gins gin NNS cord-015021-pol2qm74 2969 51 / / SYM cord-015021-pol2qm74 2969 52 L L NNP cord-015021-pol2qm74 2969 53 ) ) -RRB- cord-015021-pol2qm74 2969 54 and and CC cord-015021-pol2qm74 2969 55 albumin albumin NN cord-015021-pol2qm74 2969 56 ( ( -LRB- cord-015021-pol2qm74 2969 57 29.0 29.0 CD cord-015021-pol2qm74 2969 58 + + SYM cord-015021-pol2qm74 2969 59 1.5 1.5 CD cord-015021-pol2qm74 2969 60 gms gms NN cord-015021-pol2qm74 2969 61 / / SYM cord-015021-pol2qm74 2969 62 L l NN cord-015021-pol2qm74 2969 63 vs. vs. NN cord-015021-pol2qm74 2969 64 26.0+_1.6 26.0+_1.6 CD cord-015021-pol2qm74 2969 65 gms gms NNP cord-015021-pol2qm74 2969 66 / / SYM cord-015021-pol2qm74 2969 67 L L NNP cord-015021-pol2qm74 2969 68 ) ) -RRB- cord-015021-pol2qm74 2969 69 were be VBD cord-015021-pol2qm74 2969 70 not not RB cord-015021-pol2qm74 2969 71 different different JJ cord-015021-pol2qm74 2969 72 between between IN cord-015021-pol2qm74 2969 73 CNTF CNTF NNP cord-015021-pol2qm74 2969 74 and and CC cord-015021-pol2qm74 2969 75 freely freely RB cord-015021-pol2qm74 2969 76 fed feed VBD cord-015021-pol2qm74 2969 77 animals animal NNS cord-015021-pol2qm74 2969 78 . . . cord-015021-pol2qm74 2970 1 We -PRON- PRP cord-015021-pol2qm74 2970 2 conclude conclude VBP cord-015021-pol2qm74 2970 3 that that IN cord-015021-pol2qm74 2970 4 CNTF CNTF NNP cord-015021-pol2qm74 2970 5 causes cause VBZ cord-015021-pol2qm74 2970 6 anorexia anorexia NN cord-015021-pol2qm74 2970 7 , , , cord-015021-pol2qm74 2970 8 and and CC cord-015021-pol2qm74 2970 9 increases increase VBZ cord-015021-pol2qm74 2970 10 body body NN cord-015021-pol2qm74 2970 11 weight weight NN cord-015021-pol2qm74 2970 12 loss loss NN cord-015021-pol2qm74 2970 13 in in IN cord-015021-pol2qm74 2970 14 excess excess NN cord-015021-pol2qm74 2970 15 of of IN cord-015021-pol2qm74 2970 16 the the DT cord-015021-pol2qm74 2970 17 associated associate VBN cord-015021-pol2qm74 2970 18 anorexia anorexia NN cord-015021-pol2qm74 2970 19 . . . cord-015021-pol2qm74 2971 1 Unlike unlike IN cord-015021-pol2qm74 2971 2 the the DT cord-015021-pol2qm74 2971 3 cachexia cachexia NN cord-015021-pol2qm74 2971 4 associated associate VBN cord-015021-pol2qm74 2971 5 with with IN cord-015021-pol2qm74 2971 6 IL-1 IL-1 NNP cord-015021-pol2qm74 2971 7 and and CC cord-015021-pol2qm74 2971 8 TNF TNF NNP cord-015021-pol2qm74 2971 9 infusions infusion NNS cord-015021-pol2qm74 2971 10 , , , cord-015021-pol2qm74 2971 11 which which WDT cord-015021-pol2qm74 2971 12 is be VBZ cord-015021-pol2qm74 2971 13 associated associate VBN cord-015021-pol2qm74 2971 14 with with IN cord-015021-pol2qm74 2971 15 an an DT cord-015021-pol2qm74 2971 16 acute acute JJ cord-015021-pol2qm74 2971 17 phase phase NN cord-015021-pol2qm74 2971 18 response response NN cord-015021-pol2qm74 2971 19 , , , cord-015021-pol2qm74 2971 20 CNTF CNTF NNP cord-015021-pol2qm74 2971 21 acts act VBZ cord-015021-pol2qm74 2971 22 predominantly predominantly RB cord-015021-pol2qm74 2971 23 on on IN cord-015021-pol2qm74 2971 24 food food NN cord-015021-pol2qm74 2971 25 intake intake NN cord-015021-pol2qm74 2971 26 and and CC cord-015021-pol2qm74 2971 27 carcass carcass NN cord-015021-pol2qm74 2971 28 weight weight NN cord-015021-pol2qm74 2971 29 through through IN cord-015021-pol2qm74 2971 30 a a DT cord-015021-pol2qm74 2971 31 prostaglandin prostaglandin NN cord-015021-pol2qm74 2971 32 - - HYPH cord-015021-pol2qm74 2971 33 independent independent JJ cord-015021-pol2qm74 2971 34 mechanism mechanism NN cord-015021-pol2qm74 2971 35 and and CC cord-015021-pol2qm74 2971 36 has have VBZ cord-015021-pol2qm74 2971 37 only only RB cord-015021-pol2qm74 2971 38 minimal minimal JJ cord-015021-pol2qm74 2971 39 acute acute JJ cord-015021-pol2qm74 2971 40 phase phase NN cord-015021-pol2qm74 2971 41 inducing induce VBG cord-015021-pol2qm74 2971 42 properties property NNS cord-015021-pol2qm74 2971 43 , , , cord-015021-pol2qm74 2971 44 N. N. NNP cord-015021-pol2qm74 2971 45 Joseph Joseph NNP cord-015021-pol2qm74 2971 46 Espat Espat NNP cord-015021-pol2qm74 2971 47 , , , cord-015021-pol2qm74 2971 48 MD MD NNP cord-015021-pol2qm74 2971 49 . . . cord-015021-pol2qm74 2972 1 University University NNP cord-015021-pol2qm74 2972 2 of of IN cord-015021-pol2qm74 2972 3 Florida Florida NNP cord-015021-pol2qm74 2972 4 , , , cord-015021-pol2qm74 2972 5 Department Department NNP cord-015021-pol2qm74 2972 6 of of IN cord-015021-pol2qm74 2972 7 Surgery Surgery NNP cord-015021-pol2qm74 2972 8 , , , cord-015021-pol2qm74 2972 9 J J NNP cord-015021-pol2qm74 2972 10 - - HYPH cord-015021-pol2qm74 2972 11 Box Box NNP cord-015021-pol2qm74 2972 12 100286 100286 CD cord-015021-pol2qm74 2972 13 , , , cord-015021-pol2qm74 2972 14 Gainesville Gainesville NNP cord-015021-pol2qm74 2972 15 , , , cord-015021-pol2qm74 2972 16 FL FL NNP cord-015021-pol2qm74 2972 17 . . . cord-015021-pol2qm74 2973 1 32610 32610 CD cord-015021-pol2qm74 2973 2 . . . cord-015021-pol2qm74 2974 1 OF of IN cord-015021-pol2qm74 2974 2 CYTOKINES CYTOKINES NNP cord-015021-pol2qm74 2975 1 BY by IN cord-015021-pol2qm74 2975 2 NEUROTROPHIC NEUROTROPHIC NNP cord-015021-pol2qm74 2975 3 FACTORS factors NN cord-015021-pol2qm74 2975 4 , , , cord-015021-pol2qm74 2976 1 THE the DT cord-015021-pol2qm74 2976 2 NEUROENDOCRINE NEUROENDOCRINE NNP cord-015021-pol2qm74 2976 3 SYSTEM system NN cord-015021-pol2qm74 2976 4 AND and CC cord-015021-pol2qm74 2976 5 PHENOTIAZINES PHENOTIAZINES NNP cord-015021-pol2qm74 2976 6 . . . cord-015021-pol2qm74 2977 1 Cytokines cytokine NNS cord-015021-pol2qm74 2977 2 , , , cord-015021-pol2qm74 2977 3 including include VBG cord-015021-pol2qm74 2977 4 TNF TNF NNP cord-015021-pol2qm74 2977 5 and and CC cord-015021-pol2qm74 2977 6 IL-1 IL-1 NNP cord-015021-pol2qm74 2977 7 , , , cord-015021-pol2qm74 2977 8 have have VBP cord-015021-pol2qm74 2977 9 a a DT cord-015021-pol2qm74 2977 10 pathogenetic pathogenetic JJ cord-015021-pol2qm74 2977 11 role role NN cord-015021-pol2qm74 2977 12 in in IN cord-015021-pol2qm74 2977 13 various various JJ cord-015021-pol2qm74 2977 14 diseases disease NNS cord-015021-pol2qm74 2977 15 related relate VBN cord-015021-pol2qm74 2977 16 to to IN cord-015021-pol2qm74 2977 17 infection infection NN cord-015021-pol2qm74 2977 18 and and CC cord-015021-pol2qm74 2977 19 inflammation inflammation NN cord-015021-pol2qm74 2977 20 . . . cord-015021-pol2qm74 2978 1 The the DT cord-015021-pol2qm74 2978 2 action action NN cord-015021-pol2qm74 2978 3 and/or and/or CC cord-015021-pol2qm74 2978 4 production production NN cord-015021-pol2qm74 2978 5 of of IN cord-015021-pol2qm74 2978 6 cytokines cytokine NNS cord-015021-pol2qm74 2978 7 can can MD cord-015021-pol2qm74 2978 8 be be VB cord-015021-pol2qm74 2978 9 regulated regulate VBN cord-015021-pol2qm74 2978 10 by by IN cord-015021-pol2qm74 2978 11 drugs drug NNS cord-015021-pol2qm74 2978 12 or or CC cord-015021-pol2qm74 2978 13 endogenous endogenous JJ cord-015021-pol2qm74 2978 14 mechanisms mechanism NNS cord-015021-pol2qm74 2978 15 that that WDT cord-015021-pol2qm74 2978 16 involve involve VBP cord-015021-pol2qm74 2978 17 the the DT cord-015021-pol2qm74 2978 18 cetral cetral JJ cord-015021-pol2qm74 2978 19 nervous nervous JJ cord-015021-pol2qm74 2978 20 system system NN cord-015021-pol2qm74 2978 21 ( ( -LRB- cord-015021-pol2qm74 2978 22 CNS CNS NNP cord-015021-pol2qm74 2978 23 ) ) -RRB- cord-015021-pol2qm74 2979 1 We -PRON- PRP cord-015021-pol2qm74 2979 2 found find VBD cord-015021-pol2qm74 2979 3 that that IN cord-015021-pol2qm74 2979 4 the the DT cord-015021-pol2qm74 2979 5 antipsychotic antipsychotic JJ cord-015021-pol2qm74 2979 6 chlorpromazine chlorpromazine NN cord-015021-pol2qm74 2979 7 ( ( -LRB- cord-015021-pol2qm74 2979 8 CPZ CPZ NNP cord-015021-pol2qm74 2979 9 ) ) -RRB- cord-015021-pol2qm74 2979 10 potently potently RB cord-015021-pol2qm74 2979 11 inhibits inhibit VBZ cord-015021-pol2qm74 2979 12 TNF tnf NN cord-015021-pol2qm74 2979 13 production production NN cord-015021-pol2qm74 2979 14 and and CC cord-015021-pol2qm74 2979 15 protects protect VBZ cord-015021-pol2qm74 2979 16 mice mouse NNS cord-015021-pol2qm74 2979 17 against against IN cord-015021-pol2qm74 2979 18 endotoxic endotoxic JJ cord-015021-pol2qm74 2979 19 shock shock NN cord-015021-pol2qm74 2979 20 . . . cord-015021-pol2qm74 2980 1 CPZ CPZ NNP cord-015021-pol2qm74 2980 2 also also RB cord-015021-pol2qm74 2980 3 inhibits inhibit VBZ cord-015021-pol2qm74 2980 4 brain brain NN cord-015021-pol2qm74 2980 5 TNF TNF NNP cord-015021-pol2qm74 2980 6 production production NN cord-015021-pol2qm74 2980 7 in in IN cord-015021-pol2qm74 2980 8 mice mice NN cord-015021-pol2qm74 2980 9 intracerebrally intracerebrally RB cord-015021-pol2qm74 2980 10 injected inject VBN cord-015021-pol2qm74 2980 11 with with IN cord-015021-pol2qm74 2980 12 endotoxin endotoxin NN cord-015021-pol2qm74 2980 13 , , , cord-015021-pol2qm74 2980 14 whereas whereas IN cord-015021-pol2qm74 2980 15 CPZ CPZ NNP cord-015021-pol2qm74 2980 16 analogs analog NNS cord-015021-pol2qm74 2980 17 that that WDT cord-015021-pol2qm74 2980 18 do do VBP cord-015021-pol2qm74 2980 19 not not RB cord-015021-pol2qm74 2980 20 cross cross VB cord-015021-pol2qm74 2980 21 the the DT cord-015021-pol2qm74 2980 22 blood blood NN cord-015021-pol2qm74 2980 23 - - HYPH cord-015021-pol2qm74 2980 24 brain brain NN cord-015021-pol2qm74 2980 25 barrier barrier NN cord-015021-pol2qm74 2980 26 inhibit inhibit VBP cord-015021-pol2qm74 2980 27 only only RB cord-015021-pol2qm74 2980 28 perypheral perypheral JJ cord-015021-pol2qm74 2980 29 , , , cord-015021-pol2qm74 2980 30 not not RB cord-015021-pol2qm74 2980 31 brain brain NN cord-015021-pol2qm74 2980 32 , , , cord-015021-pol2qm74 2980 33 TNF TNF NNP cord-015021-pol2qm74 2980 34 . . . cord-015021-pol2qm74 2981 1 TNF tnf NN cord-015021-pol2qm74 2981 2 production production NN cord-015021-pol2qm74 2981 3 and and CC cord-015021-pol2qm74 2981 4 susceptibility susceptibility NN cord-015021-pol2qm74 2981 5 to to IN cord-015021-pol2qm74 2981 6 the the DT cord-015021-pol2qm74 2981 7 toxicity toxicity NN cord-015021-pol2qm74 2981 8 of of IN cord-015021-pol2qm74 2981 9 endotoxin endotoxin NN cord-015021-pol2qm74 2981 10 , , , cord-015021-pol2qm74 2981 11 TNF TNF NNP cord-015021-pol2qm74 2981 12 and and CC cord-015021-pol2qm74 2981 13 IL-1 IL-1 NNP cord-015021-pol2qm74 2981 14 are be VBP cord-015021-pol2qm74 2981 15 increased increase VBN cord-015021-pol2qm74 2981 16 in in IN cord-015021-pol2qm74 2981 17 adrenalectomized adrenalectomize VBN cord-015021-pol2qm74 2981 18 mice mouse NNS cord-015021-pol2qm74 2981 19 , , , cord-015021-pol2qm74 2981 20 indicating indicate VBG cord-015021-pol2qm74 2981 21 that that IN cord-015021-pol2qm74 2981 22 endogenous endogenous JJ cord-015021-pol2qm74 2981 23 corticosterone corticosterone NN cord-015021-pol2qm74 2981 24 ( ( -LRB- cord-015021-pol2qm74 2981 25 CS CS NNP cord-015021-pol2qm74 2981 26 ) ) -RRB- cord-015021-pol2qm74 2981 27 controls control VBZ cord-015021-pol2qm74 2981 28 cytokine cytokine NN cord-015021-pol2qm74 2981 29 production production NN cord-015021-pol2qm74 2981 30 and and CC cord-015021-pol2qm74 2981 31 toxicity toxicity NN cord-015021-pol2qm74 2981 32 , , , cord-015021-pol2qm74 2981 33 in in IN cord-015021-pol2qm74 2981 34 a a DT cord-015021-pol2qm74 2981 35 feedback feedback NN cord-015021-pol2qm74 2981 36 fashion fashion NN cord-015021-pol2qm74 2981 37 since since IN cord-015021-pol2qm74 2981 38 endotoxin endotoxin NN cord-015021-pol2qm74 2981 39 and and CC cord-015021-pol2qm74 2981 40 cytokines cytokine NNS cord-015021-pol2qm74 2981 41 increase increase VBP cord-015021-pol2qm74 2981 42 serum serum NN cord-015021-pol2qm74 2981 43 CS cs NN cord-015021-pol2qm74 2981 44 . . . cord-015021-pol2qm74 2982 1 Increased increase VBN cord-015021-pol2qm74 2982 2 TNF TNF NNP cord-015021-pol2qm74 2982 3 production production NN cord-015021-pol2qm74 2982 4 was be VBD cord-015021-pol2qm74 2982 5 also also RB cord-015021-pol2qm74 2982 6 observed observe VBN cord-015021-pol2qm74 2982 7 in in IN cord-015021-pol2qm74 2982 8 mice mouse NNS cord-015021-pol2qm74 2982 9 where where WRB cord-015021-pol2qm74 2982 10 the the DT cord-015021-pol2qm74 2982 11 hypothalamus hypothalamus NN cord-015021-pol2qm74 2982 12 - - HYPH cord-015021-pol2qm74 2982 13 pituitary pituitary NN cord-015021-pol2qm74 2982 14 - - HYPH cord-015021-pol2qm74 2982 15 adrenal adrenal NN cord-015021-pol2qm74 2982 16 axis axis NN cord-015021-pol2qm74 2982 17 was be VBD cord-015021-pol2qm74 2982 18 blocked block VBN cord-015021-pol2qm74 2982 19 by by IN cord-015021-pol2qm74 2982 20 chronic chronic JJ cord-015021-pol2qm74 2982 21 administration administration NN cord-015021-pol2qm74 2982 22 of of IN cord-015021-pol2qm74 2982 23 dexamethasone dexamethasone NNP cord-015021-pol2qm74 2982 24 , , , cord-015021-pol2qm74 2982 25 following follow VBG cord-015021-pol2qm74 2982 26 a a DT cord-015021-pol2qm74 2982 27 two two CD cord-015021-pol2qm74 2982 28 - - HYPH cord-015021-pol2qm74 2982 29 day day NN cord-015021-pol2qm74 2982 30 washout washout NN cord-015021-pol2qm74 2982 31 . . . cord-015021-pol2qm74 2983 1 Administration administration NN cord-015021-pol2qm74 2983 2 of of IN cord-015021-pol2qm74 2983 3 cytokines cytokine NNS cord-015021-pol2qm74 2983 4 acting act VBG cord-015021-pol2qm74 2983 5 through through IN cord-015021-pol2qm74 2983 6 the the DT cord-015021-pol2qm74 2983 7 gp130 gp130 NNP cord-015021-pol2qm74 2983 8 signal signal NN cord-015021-pol2qm74 2983 9 transd transd NN cord-015021-pol2qm74 2983 10 , , , cord-015021-pol2qm74 2983 11 uction uction NNP cord-015021-pol2qm74 2983 12 protein protein NN cord-015021-pol2qm74 2983 13 , , , cord-015021-pol2qm74 2983 14 including include VBG cord-015021-pol2qm74 2983 15 IL-6 IL-6 NNP cord-015021-pol2qm74 2983 16 and and CC cord-015021-pol2qm74 2983 17 ciliary ciliary NN cord-015021-pol2qm74 2983 18 neurotrophic neurotrophic NN cord-015021-pol2qm74 2983 19 factor factor NN cord-015021-pol2qm74 2983 20 , , , cord-015021-pol2qm74 2983 21 CNTF CNTF NNP cord-015021-pol2qm74 2983 22 potentiated potentiate VBD cord-015021-pol2qm74 2983 23 IL IL NNP cord-015021-pol2qm74 2983 24 - - HYPH cord-015021-pol2qm74 2983 25 l l NN cord-015021-pol2qm74 2983 26 - - HYPH cord-015021-pol2qm74 2983 27 induced induce VBN cord-015021-pol2qm74 2983 28 elevation elevation NN cord-015021-pol2qm74 2983 29 of of IN cord-015021-pol2qm74 2983 30 CS CS NNP cord-015021-pol2qm74 2983 31 . . . cord-015021-pol2qm74 2984 1 IL-6 IL-6 NNP cord-015021-pol2qm74 2984 2 and and CC cord-015021-pol2qm74 2984 3 CNTF CNTF NNP cord-015021-pol2qm74 2984 4 also also RB cord-015021-pol2qm74 2984 5 induced induce VBD cord-015021-pol2qm74 2984 6 hepatic hepatic JJ cord-015021-pol2qm74 2984 7 acute acute JJ cord-015021-pol2qm74 2984 8 - - HYPH cord-015021-pol2qm74 2984 9 phase phase NN cord-015021-pol2qm74 2984 10 proteins protein NNS cord-015021-pol2qm74 2984 11 . . . cord-015021-pol2qm74 2985 1 Thus thus RB cord-015021-pol2qm74 2985 2 IL-6 IL-6 NNP cord-015021-pol2qm74 2985 3 and and CC cord-015021-pol2qm74 2985 4 CNTF CNTF NNP cord-015021-pol2qm74 2985 5 might may MD cord-015021-pol2qm74 2985 6 have have VB cord-015021-pol2qm74 2985 7 antiinflammatory antiinflammatory JJ cord-015021-pol2qm74 2985 8 activity activity NN cord-015021-pol2qm74 2985 9 , , , cord-015021-pol2qm74 2985 10 by by IN cord-015021-pol2qm74 2985 11 potentiating potentiate VBG cord-015021-pol2qm74 2985 12 the the DT cord-015021-pol2qm74 2985 13 feedback feedback NN cord-015021-pol2qm74 2985 14 responses response NNS cord-015021-pol2qm74 2985 15 of of IN cord-015021-pol2qm74 2985 16 the the DT cord-015021-pol2qm74 2985 17 neuroendocrine neuroendocrine JJ cord-015021-pol2qm74 2985 18 axis axis NN cord-015021-pol2qm74 2985 19 . . . cord-015021-pol2qm74 2986 1 These these DT cord-015021-pol2qm74 2986 2 data datum NNS cord-015021-pol2qm74 2986 3 indicate indicate VBP cord-015021-pol2qm74 2986 4 how how WRB cord-015021-pol2qm74 2986 5 complex complex JJ cord-015021-pol2qm74 2986 6 can can MD cord-015021-pol2qm74 2986 7 be be VB cord-015021-pol2qm74 2986 8 the the DT cord-015021-pol2qm74 2986 9 interregulatory interregulatory JJ cord-015021-pol2qm74 2986 10 relationships relationship NNS cord-015021-pol2qm74 2986 11 between between IN cord-015021-pol2qm74 2986 12 the the DT cord-015021-pol2qm74 2986 13 brain brain NN cord-015021-pol2qm74 2986 14 and and CC cord-015021-pol2qm74 2986 15 the the DT cord-015021-pol2qm74 2986 16 immune immune JJ cord-015021-pol2qm74 2986 17 system system NN cord-015021-pol2qm74 2986 18 , , , cord-015021-pol2qm74 2986 19 how how WRB cord-015021-pol2qm74 2986 20 they -PRON- PRP cord-015021-pol2qm74 2986 21 can can MD cord-015021-pol2qm74 2986 22 be be VB cord-015021-pol2qm74 2986 23 used use VBN cord-015021-pol2qm74 2986 24 to to IN cord-015021-pol2qm74 2986 25 pharmacomodulate pharmacomodulate NNP cord-015021-pol2qm74 2986 26 cytokine cytokine JJ cord-015021-pol2qm74 2986 27 action action NN cord-015021-pol2qm74 2986 28 and and CC cord-015021-pol2qm74 2986 29 how how WRB cord-015021-pol2qm74 2986 30 their -PRON- PRP$ cord-015021-pol2qm74 2986 31 disregulation disregulation NN cord-015021-pol2qm74 2986 32 might may MD cord-015021-pol2qm74 2986 33 exacerbate exacerbate VB cord-015021-pol2qm74 2986 34 IL-1-and IL-1-and NNP cord-015021-pol2qm74 2986 35 TNF TNF NNP cord-015021-pol2qm74 2986 36 - - HYPH cord-015021-pol2qm74 2986 37 mediated mediate VBN cord-015021-pol2qm74 2986 38 pathologies pathology NNS cord-015021-pol2qm74 2986 39 . . . cord-015021-pol2qm74 2987 1 Lipopolysaccharide Lipopolysaccharide NNP cord-015021-pol2qm74 2987 2 ( ( -LRB- cord-015021-pol2qm74 2987 3 LPS LPS NNP cord-015021-pol2qm74 2987 4 ) ) -RRB- cord-015021-pol2qm74 2987 5 constitutes constitute VBZ cord-015021-pol2qm74 2987 6 a a DT cord-015021-pol2qm74 2987 7 well well RB cord-015021-pol2qm74 2987 8 established establish VBN cord-015021-pol2qm74 2987 9 activator activator NN cord-015021-pol2qm74 2987 10 of of IN cord-015021-pol2qm74 2987 11 monocytes/ monocytes/ CD cord-015021-pol2qm74 2987 12 macrophages macrophage NNS cord-015021-pol2qm74 2987 13 ( ( -LRB- cord-015021-pol2qm74 2987 14 MIZI MIZI NNP cord-015021-pol2qm74 2987 15 ) ) -RRB- cord-015021-pol2qm74 2987 16 and and CC cord-015021-pol2qm74 2987 17 murine murine JJ cord-015021-pol2qm74 2987 18 B b NN cord-015021-pol2qm74 2987 19 lymphocytes lymphocyte NNS cord-015021-pol2qm74 2987 20 . . . cord-015021-pol2qm74 2988 1 The the DT cord-015021-pol2qm74 2988 2 hydrophobic hydrophobic JJ cord-015021-pol2qm74 2988 3 part part NN cord-015021-pol2qm74 2988 4 of of IN cord-015021-pol2qm74 2988 5 LPS LPS NNP cord-015021-pol2qm74 2988 6 , , , cord-015021-pol2qm74 2988 7 termed term VBD cord-015021-pol2qm74 2988 8 lipid lipid NN cord-015021-pol2qm74 2988 9 A a NN cord-015021-pol2qm74 2988 10 , , , cord-015021-pol2qm74 2988 11 represents represent VBZ cord-015021-pol2qm74 2988 12 the the DT cord-015021-pol2qm74 2988 13 endotoxic endotoxic JJ cord-015021-pol2qm74 2988 14 principle principle NN cord-015021-pol2qm74 2988 15 of of IN cord-015021-pol2qm74 2988 16 LPS LPS NNP cord-015021-pol2qm74 2988 17 . . . cord-015021-pol2qm74 2989 1 We -PRON- PRP cord-015021-pol2qm74 2989 2 now now RB cord-015021-pol2qm74 2989 3 demonstrate demonstrate VBP cord-015021-pol2qm74 2989 4 that that IN cord-015021-pol2qm74 2989 5 LPS LPS NNP cord-015021-pol2qm74 2989 6 is be VBZ cord-015021-pol2qm74 2989 7 also also RB cord-015021-pol2qm74 2989 8 capable capable JJ cord-015021-pol2qm74 2989 9 of of IN cord-015021-pol2qm74 2989 10 inducing induce VBG cord-015021-pol2qm74 2989 11 proliferation proliferation NN cord-015021-pol2qm74 2989 12 of of IN cord-015021-pol2qm74 2989 13 human human JJ cord-015021-pol2qm74 2989 14 T t NN cord-015021-pol2qm74 2989 15 cells cell NNS cord-015021-pol2qm74 2989 16 at at IN cord-015021-pol2qm74 2989 17 a a DT cord-015021-pol2qm74 2989 18 dose dose NN cord-015021-pol2qm74 2989 19 of of IN cord-015021-pol2qm74 2989 20 10 10 CD cord-015021-pol2qm74 2989 21 to to TO cord-015021-pol2qm74 2989 22 1000 1000 CD cord-015021-pol2qm74 2989 23 pg pg NN cord-015021-pol2qm74 2989 24 / / SYM cord-015021-pol2qm74 2989 25 ml ml NN cord-015021-pol2qm74 2989 26 . . . cord-015021-pol2qm74 2990 1 The the DT cord-015021-pol2qm74 2990 2 specificity specificity NN cord-015021-pol2qm74 2990 3 of of IN cord-015021-pol2qm74 2990 4 this this DT cord-015021-pol2qm74 2990 5 stimulation stimulation NN cord-015021-pol2qm74 2990 6 was be VBD cord-015021-pol2qm74 2990 7 analysed analyse VBN cord-015021-pol2qm74 2990 8 by by IN cord-015021-pol2qm74 2990 9 the the DT cord-015021-pol2qm74 2990 10 following follow VBG cord-015021-pol2qm74 2990 11 experiments experiment NNS cord-015021-pol2qm74 2990 12 : : : cord-015021-pol2qm74 2990 13 i i NN cord-015021-pol2qm74 2990 14 ) ) -RRB- cord-015021-pol2qm74 2991 1 The the DT cord-015021-pol2qm74 2991 2 synthetic synthetic JJ cord-015021-pol2qm74 2991 3 hexaacyl hexaacyl NNP cord-015021-pol2qm74 2991 4 Escherichia Escherichia NNP cord-015021-pol2qm74 2991 5 coiltype coiltype NN cord-015021-pol2qm74 2991 6 lipid lipid NN cord-015021-pol2qm74 2991 7 A a DT cord-015021-pol2qm74 2991 8 ( ( -LRB- cord-015021-pol2qm74 2991 9 compound compound NN cord-015021-pol2qm74 2991 10 506 506 CD cord-015021-pol2qm74 2991 11 ) ) -RRB- cord-015021-pol2qm74 2991 12 also also RB cord-015021-pol2qm74 2991 13 stimulated stimulate VBD cord-015021-pol2qm74 2991 14 human human JJ cord-015021-pol2qm74 2991 15 T t NN cord-015021-pol2qm74 2991 16 cells cell NNS cord-015021-pol2qm74 2991 17 ; ; : cord-015021-pol2qm74 2991 18 ii ii LS cord-015021-pol2qm74 2991 19 ) ) -RRB- cord-015021-pol2qm74 2991 20 the the DT cord-015021-pol2qm74 2991 21 synthetic synthetic JJ cord-015021-pol2qm74 2991 22 tetraacyl tetraacyl NNP cord-015021-pol2qm74 2991 23 lipid lipid NN cord-015021-pol2qm74 2991 24 A a DT cord-015021-pol2qm74 2991 25 precursor precursor NN cord-015021-pol2qm74 2991 26 ( ( -LRB- cord-015021-pol2qm74 2991 27 compound compound NN cord-015021-pol2qm74 2991 28 406 406 CD cord-015021-pol2qm74 2991 29 ) ) -RRB- cord-015021-pol2qm74 2991 30 or or CC cord-015021-pol2qm74 2991 31 the the DT cord-015021-pol2qm74 2991 32 1phosphono 1phosphono CD cord-015021-pol2qm74 2991 33 - - HYPH cord-015021-pol2qm74 2991 34 oxyethyl oxyethyl NN cord-015021-pol2qm74 2991 35 analogue analogue NN cord-015021-pol2qm74 2991 36 PE-4 PE-4 NNP cord-015021-pol2qm74 2991 37 , , , cord-015021-pol2qm74 2991 38 structures structure NNS cord-015021-pol2qm74 2991 39 known know VBN cord-015021-pol2qm74 2991 40 to to TO cord-015021-pol2qm74 2991 41 antagonize antagonize VB cord-015021-pol2qm74 2991 42 LPS LPS NNP cord-015021-pol2qm74 2991 43 - - HYPH cord-015021-pol2qm74 2991 44 induced induce VBN cord-015021-pol2qm74 2991 45 monokine monokine NN cord-015021-pol2qm74 2991 46 production production NN cord-015021-pol2qm74 2991 47 in in IN cord-015021-pol2qm74 2991 48 human human JJ cord-015021-pol2qm74 2991 49 MZ MZ NNP cord-015021-pol2qm74 2991 50 , , , cord-015021-pol2qm74 2991 51 also also RB cord-015021-pol2qm74 2991 52 inhibited inhibit VBD cord-015021-pol2qm74 2991 53 LPSinduced LPSinduced NNP cord-015021-pol2qm74 2991 54 T t NN cord-015021-pol2qm74 2991 55 - - HYPH cord-015021-pol2qm74 2991 56 cell cell NN cord-015021-pol2qm74 2991 57 proliferation proliferation NN cord-015021-pol2qm74 2991 58 . . . cord-015021-pol2qm74 2992 1 The the DT cord-015021-pol2qm74 2992 2 T t NN cord-015021-pol2qm74 2992 3 - - HYPH cord-015021-pol2qm74 2992 4 cell cell NN cord-015021-pol2qm74 2992 5 proliferation proliferation NN cord-015021-pol2qm74 2992 6 expressed express VBD cord-015021-pol2qm74 2992 7 the the DT cord-015021-pol2qm74 2992 8 following follow VBG cord-015021-pol2qm74 2992 9 features feature NNS cord-015021-pol2qm74 2992 10 : : : cord-015021-pol2qm74 2992 11 i i LS cord-015021-pol2qm74 2992 12 ) ) -RRB- cord-015021-pol2qm74 2992 13 CD4 CD4 NNP cord-015021-pol2qm74 2992 14 ÷-as ÷-as POS cord-015021-pol2qm74 2992 15 welt welt NN cord-015021-pol2qm74 2992 16 as as IN cord-015021-pol2qm74 2992 17 CD8 CD8 NNP cord-015021-pol2qm74 2992 18 ÷ ÷ NNP cord-015021-pol2qm74 2992 19 T T NNP cord-015021-pol2qm74 2992 20 cells cell NNS cord-015021-pol2qm74 2992 21 proliferate proliferate VBP cord-015021-pol2qm74 2992 22 in in IN cord-015021-pol2qm74 2992 23 response response NN cord-015021-pol2qm74 2992 24 to to IN cord-015021-pol2qm74 2992 25 LPS LPS NNP cord-015021-pol2qm74 2992 26 , , , cord-015021-pol2qm74 2992 27 ii ii NN cord-015021-pol2qm74 2992 28 ) ) -RRB- cord-015021-pol2qm74 2992 29 limiting limit VBG cord-015021-pol2qm74 2992 30 dilution dilution NN cord-015021-pol2qm74 2992 31 analyses analysis NNS cord-015021-pol2qm74 2992 32 reveal reveal VBP cord-015021-pol2qm74 2992 33 that that IN cord-015021-pol2qm74 2992 34 the the DT cord-015021-pol2qm74 2992 35 frequency frequency NN cord-015021-pol2qm74 2992 36 of of IN cord-015021-pol2qm74 2992 37 responding respond VBG cord-015021-pol2qm74 2992 38 cells cell NNS cord-015021-pol2qm74 2992 39 was be VBD cord-015021-pol2qm74 2992 40 between between IN cord-015021-pol2qm74 2992 41 1/500 1/500 CD cord-015021-pol2qm74 2992 42 to to TO cord-015021-pol2qm74 2992 43 1/1000 1/1000 CD cord-015021-pol2qm74 2992 44 cells cell NNS cord-015021-pol2qm74 2992 45 ; ; : cord-015021-pol2qm74 2992 46 iii iii LS cord-015021-pol2qm74 2992 47 ) ) -RRB- cord-015021-pol2qm74 2992 48 purified purify VBN cord-015021-pol2qm74 2992 49 T t NN cord-015021-pol2qm74 2992 50 cells cell NNS cord-015021-pol2qm74 2992 51 alone alone RB cord-015021-pol2qm74 2992 52 can can MD cord-015021-pol2qm74 2992 53 not not RB cord-015021-pol2qm74 2992 54 be be VB cord-015021-pol2qm74 2992 55 stimulated stimulate VBN cord-015021-pol2qm74 2992 56 by by IN cord-015021-pol2qm74 2992 57 LPS LPS NNP cord-015021-pol2qm74 2992 58 , , , cord-015021-pol2qm74 2992 59 but but CC cord-015021-pol2qm74 2992 60 need need VBP cord-015021-pol2qm74 2992 61 the the DT cord-015021-pol2qm74 2992 62 help help NN cord-015021-pol2qm74 2992 63 of of IN cord-015021-pol2qm74 2992 64 monocytes monocyte NNS cord-015021-pol2qm74 2992 65 . . . cord-015021-pol2qm74 2993 1 This this DT cord-015021-pol2qm74 2993 2 help help NN cord-015021-pol2qm74 2993 3 can can MD cord-015021-pol2qm74 2993 4 not not RB cord-015021-pol2qm74 2993 5 be be VB cord-015021-pol2qm74 2993 6 replaced replace VBN cord-015021-pol2qm74 2993 7 by by IN cord-015021-pol2qm74 2993 8 B b NN cord-015021-pol2qm74 2993 9 cells cell NNS cord-015021-pol2qm74 2993 10 or or CC cord-015021-pol2qm74 2993 11 fixed fix VBN cord-015021-pol2qm74 2993 12 monocytes monocyte NNS cord-015021-pol2qm74 2993 13 . . . cord-015021-pol2qm74 2994 1 Furthermore furthermore RB cord-015021-pol2qm74 2994 2 , , , cord-015021-pol2qm74 2994 3 for for IN cord-015021-pol2qm74 2994 4 activation activation NN cord-015021-pol2qm74 2994 5 a a DT cord-015021-pol2qm74 2994 6 direct direct JJ cord-015021-pol2qm74 2994 7 cell cell NN cord-015021-pol2qm74 2994 8 - - HYPH cord-015021-pol2qm74 2994 9 to to IN cord-015021-pol2qm74 2994 10 - - HYPH cord-015021-pol2qm74 2994 11 cell cell NN cord-015021-pol2qm74 2994 12 contact contact NN cord-015021-pol2qm74 2994 13 between between IN cord-015021-pol2qm74 2994 14 T t NN cord-015021-pol2qm74 2994 15 cells cell NNS cord-015021-pol2qm74 2994 16 and and CC cord-015021-pol2qm74 2994 17 monocyte monocyte NNP cord-015021-pol2qm74 2994 18 is be VBZ cord-015021-pol2qm74 2994 19 neccessary neccessary JJ cord-015021-pol2qm74 2994 20 ; ; : cord-015021-pol2qm74 2994 21 iv iv LS cord-015021-pol2qm74 2994 22 ) ) -RRB- cord-015021-pol2qm74 2994 23 T t NN cord-015021-pol2qm74 2994 24 cells cell NNS cord-015021-pol2qm74 2994 25 stimulated stimulate VBN cord-015021-pol2qm74 2994 26 with with IN cord-015021-pol2qm74 2994 27 LPS LPS NNP cord-015021-pol2qm74 2994 28 express express VBP cord-015021-pol2qm74 2994 29 mRNA mrna NN cord-015021-pol2qm74 2994 30 for for IN cord-015021-pol2qm74 2994 31 IL-2 IL-2 NNP cord-015021-pol2qm74 2994 32 and and CC cord-015021-pol2qm74 2994 33 IFNF IFNF NNP cord-015021-pol2qm74 2994 34 , , , cord-015021-pol2qm74 2994 35 but but CC cord-015021-pol2qm74 2994 36 not not RB cord-015021-pol2qm74 2994 37 for for IN cord-015021-pol2qm74 2994 38 IL-4 IL-4 NNP cord-015021-pol2qm74 2994 39 or or CC cord-015021-pol2qm74 2994 40 IL-5 IL-5 NNP cord-015021-pol2qm74 2994 41 ( ( -LRB- cord-015021-pol2qm74 2994 42 determined determine VBN cord-015021-pol2qm74 2994 43 by by IN cord-015021-pol2qm74 2994 44 PCR PCR NNP cord-015021-pol2qm74 2994 45 ) ) -RRB- cord-015021-pol2qm74 2994 46 . . . cord-015021-pol2qm74 2995 1 In in IN cord-015021-pol2qm74 2995 2 supernatants supernatant NNS cord-015021-pol2qm74 2995 3 , , , cord-015021-pol2qm74 2995 4 IFNF IFNF NNP cord-015021-pol2qm74 2995 5 was be VBD cord-015021-pol2qm74 2995 6 detectable detectable JJ cord-015021-pol2qm74 2995 7 ( ( -LRB- cord-015021-pol2qm74 2995 8 ELISA ELISA NNP cord-015021-pol2qm74 2995 9 ) ) -RRB- cord-015021-pol2qm74 2995 10 ; ; : cord-015021-pol2qm74 2995 11 v v LS cord-015021-pol2qm74 2995 12 ) ) -RRB- cord-015021-pol2qm74 2995 13 LPS LPS NNP cord-015021-pol2qm74 2995 14 - - HYPH cord-015021-pol2qm74 2995 15 activated activate VBN cord-015021-pol2qm74 2995 16 CD4 CD4 NNP cord-015021-pol2qm74 2995 17 ÷ ÷ NNP cord-015021-pol2qm74 2995 18 as as RB cord-015021-pol2qm74 2995 19 well well RB cord-015021-pol2qm74 2995 20 as as IN cord-015021-pol2qm74 2995 21 CD8 CD8 NNP cord-015021-pol2qm74 2995 22 + + CC cord-015021-pol2qm74 2995 23 T T NNP cord-015021-pol2qm74 2995 24 cells cell NNS cord-015021-pol2qm74 2995 25 express express VBP cord-015021-pol2qm74 2995 26 CD25 CD25 NNP cord-015021-pol2qm74 2995 27 , , , cord-015021-pol2qm74 2995 28 the the DT cord-015021-pol2qm74 2995 29 high high JJ cord-015021-pol2qm74 2995 30 affinity affinity NN cord-015021-pol2qm74 2995 31 IL-2 il-2 NN cord-015021-pol2qm74 2995 32 receptor receptor NN cord-015021-pol2qm74 2995 33 . . . cord-015021-pol2qm74 2996 1 Our -PRON- PRP$ cord-015021-pol2qm74 2996 2 results result NNS cord-015021-pol2qm74 2996 3 indicate indicate VBP cord-015021-pol2qm74 2996 4 that that IN cord-015021-pol2qm74 2996 5 in in IN cord-015021-pol2qm74 2996 6 contrast contrast NN cord-015021-pol2qm74 2996 7 to to IN cord-015021-pol2qm74 2996 8 previous previous JJ cord-015021-pol2qm74 2996 9 reports report NNS cord-015021-pol2qm74 2996 10 human human JJ cord-015021-pol2qm74 2996 11 T T NNP cord-015021-pol2qm74 2996 12 cells cell NNS cord-015021-pol2qm74 2996 13 respond respond VBP cord-015021-pol2qm74 2996 14 to to IN cord-015021-pol2qm74 2996 15 LPS LPS NNP cord-015021-pol2qm74 2996 16 with with IN cord-015021-pol2qm74 2996 17 IL-2 IL-2 NNP cord-015021-pol2qm74 2996 18 receptor receptor NN cord-015021-pol2qm74 2996 19 expression expression NN cord-015021-pol2qm74 2996 20 , , , cord-015021-pol2qm74 2996 21 lymphokine lymphokine NN cord-015021-pol2qm74 2996 22 production production NN cord-015021-pol2qm74 2996 23 , , , cord-015021-pol2qm74 2996 24 and and CC cord-015021-pol2qm74 2996 25 proliferation proliferation NN cord-015021-pol2qm74 2996 26 . . . cord-015021-pol2qm74 2997 1 The the DT cord-015021-pol2qm74 2997 2 reactive reactive JJ cord-015021-pol2qm74 2997 3 cells cell NNS cord-015021-pol2qm74 2997 4 appear appear VBP cord-015021-pol2qm74 2997 5 to to TO cord-015021-pol2qm74 2997 6 belong belong VB cord-015021-pol2qm74 2997 7 to to IN cord-015021-pol2qm74 2997 8 the the DT cord-015021-pol2qm74 2997 9 T,1 t,1 CD cord-015021-pol2qm74 2997 10 cell cell NN cord-015021-pol2qm74 2997 11 type type NN cord-015021-pol2qm74 2997 12 , , , cord-015021-pol2qm74 2997 13 The the DT cord-015021-pol2qm74 2997 14 finding finding NN cord-015021-pol2qm74 2997 15 that that IN cord-015021-pol2qm74 2997 16 human human JJ cord-015021-pol2qm74 2997 17 T t NN cord-015021-pol2qm74 2997 18 cells cell NNS cord-015021-pol2qm74 2997 19 can can MD cord-015021-pol2qm74 2997 20 be be VB cord-015021-pol2qm74 2997 21 activated activate VBN cord-015021-pol2qm74 2997 22 by by IN cord-015021-pol2qm74 2997 23 LPS LPS NNP cord-015021-pol2qm74 2997 24 is be VBZ cord-015021-pol2qm74 2997 25 of of IN cord-015021-pol2qm74 2997 26 important important JJ cord-015021-pol2qm74 2997 27 relevance relevance NN cord-015021-pol2qm74 2997 28 for for IN cord-015021-pol2qm74 2997 29 the the DT cord-015021-pol2qm74 2997 30 understanding understanding NN cord-015021-pol2qm74 2997 31 of of IN cord-015021-pol2qm74 2997 32 the the DT cord-015021-pol2qm74 2997 33 pathomechanisms pathomechanism NNS cord-015021-pol2qm74 2997 34 of of IN cord-015021-pol2qm74 2997 35 infections infection NNS cord-015021-pol2qm74 2997 36 by by IN cord-015021-pol2qm74 2997 37 Gramnegative Gramnegative NNP cord-015021-pol2qm74 2997 38 bacteria bacteria NNS cord-015021-pol2qm74 2997 39 . . . cord-015021-pol2qm74 2998 1 This this DT cord-015021-pol2qm74 2998 2 may may MD cord-015021-pol2qm74 2998 3 lead lead VB cord-015021-pol2qm74 2998 4 to to IN cord-015021-pol2qm74 2998 5 new new JJ cord-015021-pol2qm74 2998 6 strategies strategy NNS cord-015021-pol2qm74 2998 7 for for IN cord-015021-pol2qm74 2998 8 the the DT cord-015021-pol2qm74 2998 9 therapy therapy NN cord-015021-pol2qm74 2998 10 of of IN cord-015021-pol2qm74 2998 11 sepsis sepsis NN cord-015021-pol2qm74 2998 12 . . . cord-015021-pol2qm74 2999 1 We -PRON- PRP cord-015021-pol2qm74 2999 2 have have VBP cord-015021-pol2qm74 2999 3 recently recently RB cord-015021-pol2qm74 2999 4 shown show VBN cord-015021-pol2qm74 2999 5 that that IN cord-015021-pol2qm74 2999 6 human human JJ cord-015021-pol2qm74 2999 7 eosinophils eosinophil NNS cord-015021-pol2qm74 2999 8 produce produce VBP cord-015021-pol2qm74 2999 9 mRNA mrna NN cord-015021-pol2qm74 2999 10 for for IN cord-015021-pol2qm74 2999 11 interleukin interleukin NN cord-015021-pol2qm74 2999 12 ( ( -LRB- cord-015021-pol2qm74 2999 13 IL)-8 il)-8 RB cord-015021-pol2qm74 2999 14 when when WRB cord-015021-pol2qm74 2999 15 stimulated stimulate VBN cord-015021-pol2qm74 2999 16 with with IN cord-015021-pol2qm74 2999 17 calcium calcium NN cord-015021-pol2qm74 2999 18 ionophore ionophore NNP cord-015021-pol2qm74 2999 19 ( ( -LRB- cord-015021-pol2qm74 2999 20 Eur Eur NNP cord-015021-pol2qm74 2999 21 . . . cord-015021-pol2qm74 2999 22 J. J. NNP cord-015021-pol2qm74 2999 23 Immunol Immunol NNP cord-015021-pol2qm74 2999 24 . . . cord-015021-pol2qm74 3000 1 23 23 CD cord-015021-pol2qm74 3000 2 ( ( -LRB- cord-015021-pol2qm74 3000 3 1993 1993 CD cord-015021-pol2qm74 3000 4 ) ) -RRB- cord-015021-pol2qm74 3000 5 , , , cord-015021-pol2qm74 3000 6 956 956 CD cord-015021-pol2qm74 3000 7 ) ) -RRB- cord-015021-pol2qm74 3000 8 . . . cord-015021-pol2qm74 3001 1 We -PRON- PRP cord-015021-pol2qm74 3001 2 now now RB cord-015021-pol2qm74 3001 3 present present VBP cord-015021-pol2qm74 3001 4 evidence evidence NN cord-015021-pol2qm74 3001 5 that that IN cord-015021-pol2qm74 3001 6 human human JJ cord-015021-pol2qm74 3001 7 eosinophils eosinophil NNS cord-015021-pol2qm74 3001 8 contain contain VBP cord-015021-pol2qm74 3001 9 preformed preform VBN cord-015021-pol2qm74 3001 10 IL-8 IL-8 NNP cord-015021-pol2qm74 3001 11 protein protein NN cord-015021-pol2qm74 3001 12 although although IN cord-015021-pol2qm74 3001 13 they -PRON- PRP cord-015021-pol2qm74 3001 14 do do VBP cord-015021-pol2qm74 3001 15 not not RB cord-015021-pol2qm74 3001 16 express express VB cord-015021-pol2qm74 3001 17 mRNA mrna NN cord-015021-pol2qm74 3001 18 for for IN cord-015021-pol2qm74 3001 19 IL-8 IL-8 NNP cord-015021-pol2qm74 3001 20 as as IN cord-015021-pol2qm74 3001 21 measured measure VBN cord-015021-pol2qm74 3001 22 by by IN cord-015021-pol2qm74 3001 23 RT RT NNP cord-015021-pol2qm74 3001 24 - - HYPH cord-015021-pol2qm74 3001 25 PCR PCR NNP cord-015021-pol2qm74 3001 26 . . . cord-015021-pol2qm74 3002 1 IL-8 IL-8 NNP cord-015021-pol2qm74 3003 1 protein protein NN cord-015021-pol2qm74 3003 2 expression expression NN cord-015021-pol2qm74 3003 3 was be VBD cord-015021-pol2qm74 3003 4 determined determine VBN cord-015021-pol2qm74 3003 5 using use VBG cord-015021-pol2qm74 3003 6 specific specific JJ cord-015021-pol2qm74 3003 7 anti anti JJ cord-015021-pol2qm74 3003 8 - - JJ cord-015021-pol2qm74 3003 9 human human JJ cord-015021-pol2qm74 3003 10 IL-8 il-8 NN cord-015021-pol2qm74 3003 11 monoclonal monoclonal JJ cord-015021-pol2qm74 3003 12 antibodies antibody NNS cord-015021-pol2qm74 3003 13 by by IN cord-015021-pol2qm74 3003 14 Western western JJ cord-015021-pol2qm74 3003 15 blotting blotting NN cord-015021-pol2qm74 3003 16 , , , cord-015021-pol2qm74 3003 17 FACS FACS NNP cord-015021-pol2qm74 3003 18 analysis analysis NN cord-015021-pol2qm74 3003 19 and and CC cord-015021-pol2qm74 3003 20 immunohistochemistry immunohistochemistry NN cord-015021-pol2qm74 3003 21 . . . cord-015021-pol2qm74 3004 1 Moreover moreover RB cord-015021-pol2qm74 3004 2 , , , cord-015021-pol2qm74 3004 3 preformed preformed JJ cord-015021-pol2qm74 3004 4 IL-8 IL-8 NNP cord-015021-pol2qm74 3004 5 was be VBD cord-015021-pol2qm74 3004 6 re re VBN cord-015021-pol2qm74 3004 7 / / NN cord-015021-pol2qm74 3004 8 eased ease VBD cord-015021-pol2qm74 3004 9 into into IN cord-015021-pol2qm74 3004 10 supernatant supernatant NN cord-015021-pol2qm74 3004 11 by by IN cord-015021-pol2qm74 3004 12 99 99 CD cord-015021-pol2qm74 3004 13 % % NN cord-015021-pol2qm74 3004 14 pure pure JJ cord-015021-pol2qm74 3004 15 eosinophils eosinophil NNS cord-015021-pol2qm74 3004 16 after after IN cord-015021-pol2qm74 3004 17 priming prime VBG cord-015021-pol2qm74 3004 18 with with IN cord-015021-pol2qm74 3004 19 GM GM NNP cord-015021-pol2qm74 3004 20 - - HYPH cord-015021-pol2qm74 3004 21 CSF CSF NNP cord-015021-pol2qm74 3004 22 or or CC cord-015021-pol2qm74 3005 1 IL-5 IL-5 NNP cord-015021-pol2qm74 3005 2 and and CC cord-015021-pol2qm74 3005 3 subsequent subsequent JJ cord-015021-pol2qm74 3005 4 25-min 25-min CD cord-015021-pol2qm74 3005 5 stimulation stimulation NN cord-015021-pol2qm74 3005 6 with with IN cord-015021-pol2qm74 3005 7 PAF PAF NNP cord-015021-pol2qm74 3005 8 , , , cord-015021-pol2qm74 3005 9 RANTES RANTES NNP cord-015021-pol2qm74 3005 10 , , , cord-015021-pol2qm74 3005 11 ionomycin ionomycin NNS cord-015021-pol2qm74 3005 12 or or CC cord-015021-pol2qm74 3005 13 PMA PMA NNP cord-015021-pol2qm74 3005 14 , , , cord-015021-pol2qm74 3005 15 however however RB cord-015021-pol2qm74 3005 16 not not RB cord-015021-pol2qm74 3005 17 with with IN cord-015021-pol2qm74 3006 1 IL-1 IL-1 NNP cord-015021-pol2qm74 3006 2 or or CC cord-015021-pol2qm74 3006 3 IL-2 IL-2 NNP cord-015021-pol2qm74 3006 4 , , , cord-015021-pol2qm74 3006 5 as as IN cord-015021-pol2qm74 3006 6 measured measure VBN cord-015021-pol2qm74 3006 7 by by IN cord-015021-pol2qm74 3006 8 ELISA ELISA NNP cord-015021-pol2qm74 3006 9 . . . cord-015021-pol2qm74 3007 1 This this DT cord-015021-pol2qm74 3007 2 observation observation NN cord-015021-pol2qm74 3007 3 implies imply VBZ cord-015021-pol2qm74 3007 4 that that IN cord-015021-pol2qm74 3007 5 activation activation NN cord-015021-pol2qm74 3007 6 of of IN cord-015021-pol2qm74 3007 7 protein protein NN cord-015021-pol2qm74 3007 8 kinase kinase NN cord-015021-pol2qm74 3007 9 C c NN cord-015021-pol2qm74 3007 10 and/or and/or CC cord-015021-pol2qm74 3007 11 intracellular intracellular JJ cord-015021-pol2qm74 3007 12 calcium calcium NN cord-015021-pol2qm74 3007 13 mobilization mobilization NN cord-015021-pol2qm74 3007 14 are be VBP cord-015021-pol2qm74 3007 15 necessary necessary JJ cord-015021-pol2qm74 3007 16 events event NNS cord-015021-pol2qm74 3007 17 for for IN cord-015021-pol2qm74 3007 18 IL-8 IL-8 NNP cord-015021-pol2qm74 3007 19 release release NN cord-015021-pol2qm74 3007 20 in in IN cord-015021-pol2qm74 3007 21 human human JJ cord-015021-pol2qm74 3007 22 eosinophils eosinophil NNS cord-015021-pol2qm74 3007 23 . . . cord-015021-pol2qm74 3008 1 The the DT cord-015021-pol2qm74 3008 2 determined determined JJ cord-015021-pol2qm74 3008 3 amounts amount NNS cord-015021-pol2qm74 3008 4 of of IN cord-015021-pol2qm74 3008 5 preformed preformed JJ cord-015021-pol2qm74 3008 6 IL-8 IL-8 NNP cord-015021-pol2qm74 3008 7 protein protein NN cord-015021-pol2qm74 3008 8 was be VBD cord-015021-pol2qm74 3008 9 higher high JJR cord-015021-pol2qm74 3008 10 in in IN cord-015021-pol2qm74 3008 11 patients patient NNS cord-015021-pol2qm74 3008 12 with with IN cord-015021-pol2qm74 3008 13 asthma asthma NN cord-015021-pol2qm74 3008 14 compared compare VBN cord-015021-pol2qm74 3008 15 to to IN cord-015021-pol2qm74 3008 16 normal normal JJ cord-015021-pol2qm74 3008 17 individuals individual NNS cord-015021-pol2qm74 3008 18 suggesting suggest VBG cord-015021-pol2qm74 3008 19 a a DT cord-015021-pol2qm74 3008 20 role role NN cord-015021-pol2qm74 3008 21 for for IN cord-015021-pol2qm74 3008 22 eosinonhi eosinonhi NNP cord-015021-pol2qm74 3008 23 ! ! . cord-015021-pol2qm74 3009 1 derived derive VBN cord-015021-pol2qm74 3009 2 IL-8 IL-8 NNP cord-015021-pol2qm74 3009 3 in in IN cord-015021-pol2qm74 3009 4 asthma asthma NN cord-015021-pol2qm74 3009 5 . . . cord-015021-pol2qm74 3010 1 Since since IN cord-015021-pol2qm74 3010 2 the the DT cord-015021-pol2qm74 3010 3 eosinopnit eosinopnit NNP cord-015021-pol2qm74 3010 4 is be VBZ cord-015021-pol2qm74 3010 5 the the DT cord-015021-pol2qm74 3010 6 , , , cord-015021-pol2qm74 3010 7 , , , cord-015021-pol2qm74 3010 8 r~:=z r~:=z NNP cord-015021-pol2qm74 3010 9 ~ ~ NFP cord-015021-pol2qm74 3010 10 mmant mmant JJ cord-015021-pol2qm74 3010 11 cell cell NN cord-015021-pol2qm74 3010 12 in in IN cord-015021-pol2qm74 3010 13 the the DT cord-015021-pol2qm74 3010 14 asthmatic asthmatic JJ cord-015021-pol2qm74 3010 15 airways airways NNP cord-015021-pol2qm74 3010 16 , , , cord-015021-pol2qm74 3010 17 we -PRON- PRP cord-015021-pol2qm74 3010 18 determined determine VBD cord-015021-pol2qm74 3010 19 IL-8 IL-8 NNP cord-015021-pol2qm74 3010 20 concentrations concentration NNS cord-015021-pol2qm74 3010 21 in in IN cord-015021-pol2qm74 3010 22 bronchoaIveolar bronchoaiveolar JJ cord-015021-pol2qm74 3010 23 lavage lavage NN cord-015021-pol2qm74 3010 24 ( ( -LRB- cord-015021-pol2qm74 3010 25 BAL bal NN cord-015021-pol2qm74 3010 26 . . . cord-015021-pol2qm74 3011 1 ~ids ~id NNS cord-015021-pol2qm74 3011 2 from from IN cord-015021-pol2qm74 3011 3 normal normal JJ cord-015021-pol2qm74 3011 4 ! ! . cord-015021-pol2qm74 3012 1 i~.~iJvtduals i~.~ijvtdual NNS cord-015021-pol2qm74 3012 2 and and CC cord-015021-pol2qm74 3012 3 asthmatic asthmatic JJ cord-015021-pol2qm74 3012 4 patients patient NNS cord-015021-pol2qm74 3012 5 . . . cord-015021-pol2qm74 3013 1 Indeed indeed RB cord-015021-pol2qm74 3013 2 , , , cord-015021-pol2qm74 3013 3 IL-8 IL-8 NNP cord-015021-pol2qm74 3013 4 concentrations concentration NNS cord-015021-pol2qm74 3013 5 in in IN cord-015021-pol2qm74 3013 6 BALs bal NNS cord-015021-pol2qm74 3013 7 from from IN cord-015021-pol2qm74 3013 8 both both DT cord-015021-pol2qm74 3013 9 groups group NNS cord-015021-pol2qm74 3013 10 were be VBD cord-015021-pol2qm74 3013 11 similar similar JJ cord-015021-pol2qm74 3013 12 to to IN cord-015021-pol2qm74 3013 13 those those DT cord-015021-pol2qm74 3013 14 seen see VBN cord-015021-pol2qm74 3013 15 in in IN cord-015021-pol2qm74 3013 16 the the DT cord-015021-pol2qm74 3013 17 supernatants supernatant NNS cord-015021-pol2qm74 3013 18 released release VBN cord-015021-pol2qm74 3013 19 by by IN cord-015021-pol2qm74 3013 20 activated activate VBN cord-015021-pol2qm74 3013 21 eosinophils eosinophil NNS cord-015021-pol2qm74 3013 22 . . . cord-015021-pol2qm74 3014 1 The the DT cord-015021-pol2qm74 3014 2 role role NN cord-015021-pol2qm74 3014 3 for for IN cord-015021-pol2qm74 3014 4 IL-8 IL-8 NNP cord-015021-pol2qm74 3014 5 in in IN cord-015021-pol2qm74 3014 6 asthma asthma NN cord-015021-pol2qm74 3014 7 remains remain VBZ cord-015021-pol2qm74 3014 8 to to TO cord-015021-pol2qm74 3014 9 be be VB cord-015021-pol2qm74 3014 10 determined determine VBN cord-015021-pol2qm74 3014 11 . . . cord-015021-pol2qm74 3014 12 _SP cord-015021-pol2qm74 3015 1 Based base VBN cord-015021-pol2qm74 3015 2 on on IN cord-015021-pol2qm74 3015 3 a a DT cord-015021-pol2qm74 3015 4 well well RB cord-015021-pol2qm74 3015 5 established establish VBN cord-015021-pol2qm74 3015 6 rat rat NN cord-015021-pol2qm74 3015 7 model model NN cord-015021-pol2qm74 3015 8 named name VBN cord-015021-pol2qm74 3015 9 activity activity NN cord-015021-pol2qm74 3015 10 - - HYPH cord-015021-pol2qm74 3015 11 induced induce VBN cord-015021-pol2qm74 3015 12 ulceration ulceration NN cord-015021-pol2qm74 3015 13 ( ( -LRB- cord-015021-pol2qm74 3015 14 ASU ASU NNP cord-015021-pol2qm74 3015 15 ) ) -RRB- cord-015021-pol2qm74 3015 16 or or CC cord-015021-pol2qm74 3015 17 activity activity NN cord-015021-pol2qm74 3015 18 based base VBN cord-015021-pol2qm74 3015 19 anorexia anorexia NN cord-015021-pol2qm74 3015 20 ( ( -LRB- cord-015021-pol2qm74 3015 21 ABA ABA NNP cord-015021-pol2qm74 3015 22 ) ) -RRB- cord-015021-pol2qm74 3015 23 , , , cord-015021-pol2qm74 3015 24 we -PRON- PRP cord-015021-pol2qm74 3015 25 have have VBP cord-015021-pol2qm74 3015 26 developed develop VBN cord-015021-pol2qm74 3015 27 a a DT cord-015021-pol2qm74 3015 28 rat rat NN cord-015021-pol2qm74 3015 29 model model NN cord-015021-pol2qm74 3015 30 for for IN cord-015021-pol2qm74 3015 31 chronic chronic JJ cord-015021-pol2qm74 3015 32 stress stress NN cord-015021-pol2qm74 3015 33 . . . cord-015021-pol2qm74 3016 1 Male male JJ cord-015021-pol2qm74 3016 2 rats rat NNS cord-015021-pol2qm74 3016 3 were be VBD cord-015021-pol2qm74 3016 4 exposed expose VBN cord-015021-pol2qm74 3016 5 to to IN cord-015021-pol2qm74 3016 6 a a DT cord-015021-pol2qm74 3016 7 feeding feeding NN cord-015021-pol2qm74 3016 8 schedule schedule NN cord-015021-pol2qm74 3016 9 in in IN cord-015021-pol2qm74 3016 10 order order NN cord-015021-pol2qm74 3016 11 to to TO cord-015021-pol2qm74 3016 12 reduce reduce VB cord-015021-pol2qm74 3016 13 body body NN cord-015021-pol2qm74 3016 14 weight weight NN cord-015021-pol2qm74 3016 15 by by IN cord-015021-pol2qm74 3016 16 20 20 CD cord-015021-pol2qm74 3016 17 - - SYM cord-015021-pol2qm74 3016 18 30 30 CD cord-015021-pol2qm74 3016 19 % % NN cord-015021-pol2qm74 3016 20 within within IN cord-015021-pol2qm74 3016 21 14 14 CD cord-015021-pol2qm74 3016 22 days day NNS cord-015021-pol2qm74 3016 23 . . . cord-015021-pol2qm74 3017 1 While while IN cord-015021-pol2qm74 3017 2 one one CD cord-015021-pol2qm74 3017 3 group group NN cord-015021-pol2qm74 3017 4 of of IN cord-015021-pol2qm74 3017 5 rats rat NNS cord-015021-pol2qm74 3017 6 was be VBD cord-015021-pol2qm74 3017 7 kept keep VBN cord-015021-pol2qm74 3017 8 sedentary sedentary JJ cord-015021-pol2qm74 3017 9 , , , cord-015021-pol2qm74 3017 10 the the DT cord-015021-pol2qm74 3017 11 other other JJ cord-015021-pol2qm74 3017 12 had have VBD cord-015021-pol2qm74 3017 13 access access NN cord-015021-pol2qm74 3017 14 to to IN cord-015021-pol2qm74 3017 15 a a DT cord-015021-pol2qm74 3017 16 running run VBG cord-015021-pol2qm74 3017 17 wheel wheel NN cord-015021-pol2qm74 3017 18 . . . cord-015021-pol2qm74 3018 1 Food food NN cord-015021-pol2qm74 3018 2 restricted restrict VBN cord-015021-pol2qm74 3018 3 rats rat NNS cord-015021-pol2qm74 3018 4 allowed allow VBN cord-015021-pol2qm74 3018 5 to to TO cord-015021-pol2qm74 3018 6 exercise exercise VB cord-015021-pol2qm74 3018 7 developed develop VBN cord-015021-pol2qm74 3018 8 highly highly RB cord-015021-pol2qm74 3018 9 increased increase VBN cord-015021-pol2qm74 3018 10 activity activity NN cord-015021-pol2qm74 3018 11 as as IN cord-015021-pol2qm74 3018 12 compared compare VBN cord-015021-pol2qm74 3018 13 to to IN cord-015021-pol2qm74 3018 14 ad ad NN cord-015021-pol2qm74 3018 15 libitum libitum FW cord-015021-pol2qm74 3018 16 fed feed VBD cord-015021-pol2qm74 3018 17 rats rat NNS cord-015021-pol2qm74 3018 18 in in IN cord-015021-pol2qm74 3018 19 wheels wheel NNS cord-015021-pol2qm74 3018 20 ( ( -LRB- cord-015021-pol2qm74 3018 21 ca ca UH cord-015021-pol2qm74 3018 22 . . . cord-015021-pol2qm74 3019 1 15 15 CD cord-015021-pol2qm74 3020 1 versus versus IN cord-015021-pol2qm74 3020 2 2 2 CD cord-015021-pol2qm74 3020 3 kin kin NNP cord-015021-pol2qm74 3020 4 / / SYM cord-015021-pol2qm74 3020 5 day day NN cord-015021-pol2qm74 3020 6 ) ) -RRB- cord-015021-pol2qm74 3020 7 . . . cord-015021-pol2qm74 3021 1 They -PRON- PRP cord-015021-pol2qm74 3021 2 developed develop VBD cord-015021-pol2qm74 3021 3 elevated elevated JJ cord-015021-pol2qm74 3021 4 plasma plasma NN cord-015021-pol2qm74 3021 5 corticosterone corticosterone NN cord-015021-pol2qm74 3021 6 levels level NNS cord-015021-pol2qm74 3021 7 ( ( -LRB- cord-015021-pol2qm74 3021 8 30_+5gg 30_+5gg NNP cord-015021-pol2qm74 3021 9 / / SYM cord-015021-pol2qm74 3021 10 dl dl NNP cord-015021-pol2qm74 3021 11 ) ) -RRB- cord-015021-pol2qm74 3021 12 at at IN cord-015021-pol2qm74 3021 13 their -PRON- PRP$ cord-015021-pol2qm74 3021 14 circadian circadian NN cord-015021-pol2qm74 3021 15 peak peak NN cord-015021-pol2qm74 3021 16 , , , cord-015021-pol2qm74 3021 17 increased increased JJ cord-015021-pol2qm74 3021 18 adrenal adrenal JJ cord-015021-pol2qm74 3021 19 weight weight NN cord-015021-pol2qm74 3021 20 and and CC cord-015021-pol2qm74 3021 21 decreased decrease VBD cord-015021-pol2qm74 3021 22 thymus thymus NN cord-015021-pol2qm74 3021 23 and and CC cord-015021-pol2qm74 3021 24 spleen spleen NN cord-015021-pol2qm74 3021 25 weight weight NN cord-015021-pol2qm74 3021 26 as as IN cord-015021-pol2qm74 3021 27 compared compare VBN cord-015021-pol2qm74 3021 28 to to TO cord-015021-pol2qm74 3021 29 control control VB cord-015021-pol2qm74 3021 30 rats rat NNS cord-015021-pol2qm74 3021 31 and and CC cord-015021-pol2qm74 3021 32 weight weight NN cord-015021-pol2qm74 3021 33 matched match VBD cord-015021-pol2qm74 3021 34 sedentary sedentary JJ cord-015021-pol2qm74 3021 35 rats rat NNS cord-015021-pol2qm74 3021 36 , , , cord-015021-pol2qm74 3021 37 establishing establish VBG cord-015021-pol2qm74 3021 38 this this DT cord-015021-pol2qm74 3021 39 paradigm paradigm NN cord-015021-pol2qm74 3021 40 as as IN cord-015021-pol2qm74 3021 41 a a DT cord-015021-pol2qm74 3021 42 model model NN cord-015021-pol2qm74 3021 43 of of IN cord-015021-pol2qm74 3021 44 chronic chronic JJ cord-015021-pol2qm74 3021 45 stress stress NN cord-015021-pol2qm74 3021 46 . . . cord-015021-pol2qm74 3022 1 No no DT cord-015021-pol2qm74 3022 2 differences difference NNS cord-015021-pol2qm74 3022 3 in in IN cord-015021-pol2qm74 3022 4 plasma plasma NN cord-015021-pol2qm74 3022 5 ACTH ACTH NNP cord-015021-pol2qm74 3022 6 were be VBD cord-015021-pol2qm74 3022 7 seen see VBN cord-015021-pol2qm74 3022 8 among among IN cord-015021-pol2qm74 3022 9 the the DT cord-015021-pol2qm74 3022 10 various various JJ cord-015021-pol2qm74 3022 11 groups group NNS cord-015021-pol2qm74 3022 12 , , , cord-015021-pol2qm74 3022 13 suggesting suggest VBG cord-015021-pol2qm74 3022 14 increased increase VBN cord-015021-pol2qm74 3022 15 sensitivity sensitivity NN cord-015021-pol2qm74 3022 16 of of IN cord-015021-pol2qm74 3022 17 the the DT cord-015021-pol2qm74 3022 18 adrenal adrenal JJ cord-015021-pol2qm74 3022 19 glands gland NNS cord-015021-pol2qm74 3022 20 to to IN cord-015021-pol2qm74 3022 21 ACTH ACTH NNP cord-015021-pol2qm74 3022 22 . . . cord-015021-pol2qm74 3023 1 The the DT cord-015021-pol2qm74 3023 2 effect effect NN cord-015021-pol2qm74 3023 3 of of IN cord-015021-pol2qm74 3023 4 chronic chronic JJ cord-015021-pol2qm74 3023 5 stress stress NN cord-015021-pol2qm74 3023 6 accompanied accompany VBN cord-015021-pol2qm74 3023 7 by by IN cord-015021-pol2qm74 3023 8 hypercorticism hypercorticism NN cord-015021-pol2qm74 3023 9 on on IN cord-015021-pol2qm74 3023 10 baseline baseline NN cord-015021-pol2qm74 3023 11 and and CC cord-015021-pol2qm74 3023 12 endotoxin endotoxin NN cord-015021-pol2qm74 3023 13 - - HYPH cord-015021-pol2qm74 3023 14 induced induce VBN cord-015021-pol2qm74 3023 15 cytokine cytokine NN cord-015021-pol2qm74 3023 16 levels level NNS cord-015021-pol2qm74 3023 17 was be VBD cord-015021-pol2qm74 3023 18 studied study VBN cord-015021-pol2qm74 3023 19 in in IN cord-015021-pol2qm74 3023 20 this this DT cord-015021-pol2qm74 3023 21 model model NN cord-015021-pol2qm74 3023 22 . . . cord-015021-pol2qm74 3024 1 Under under IN cord-015021-pol2qm74 3024 2 baseline baseline JJ cord-015021-pol2qm74 3024 3 conditions condition NNS cord-015021-pol2qm74 3024 4 , , , cord-015021-pol2qm74 3024 5 splenic splenic JJ cord-015021-pol2qm74 3025 1 IL-1 IL-1 NNP cord-015021-pol2qm74 3025 2 a a DT cord-015021-pol2qm74 3025 3 was be VBD cord-015021-pol2qm74 3025 4 suppressed suppress VBN cord-015021-pol2qm74 3025 5 in in IN cord-015021-pol2qm74 3025 6 both both DT cord-015021-pol2qm74 3025 7 food food NN cord-015021-pol2qm74 3025 8 - - HYPH cord-015021-pol2qm74 3025 9 restricted restrict VBN cord-015021-pol2qm74 3025 10 groups group NNS cord-015021-pol2qm74 3025 11 . . . cord-015021-pol2qm74 3026 1 This this DT cord-015021-pol2qm74 3026 2 was be VBD cord-015021-pol2qm74 3026 3 more more RBR cord-015021-pol2qm74 3026 4 pronounced pronounce VBN cord-015021-pol2qm74 3026 5 in in IN cord-015021-pol2qm74 3026 6 rats rat NNS cord-015021-pol2qm74 3026 7 with with IN cord-015021-pol2qm74 3026 8 access access NN cord-015021-pol2qm74 3026 9 to to IN cord-015021-pol2qm74 3026 10 a a DT cord-015021-pol2qm74 3026 11 running run VBG cord-015021-pol2qm74 3026 12 wheel wheel NN cord-015021-pol2qm74 3026 13 . . . cord-015021-pol2qm74 3027 1 IL-6 IL-6 NNP cord-015021-pol2qm74 3027 2 and and CC cord-015021-pol2qm74 3027 3 TNF TNF NNP cord-015021-pol2qm74 3027 4 activity activity NN cord-015021-pol2qm74 3027 5 in in IN cord-015021-pol2qm74 3027 6 plasma plasma NN cord-015021-pol2qm74 3027 7 was be VBD cord-015021-pol2qm74 3027 8 not not RB cord-015021-pol2qm74 3027 9 affected affect VBN cord-015021-pol2qm74 3027 10 . . . cord-015021-pol2qm74 3028 1 After after IN cord-015021-pol2qm74 3028 2 administration administration NN cord-015021-pol2qm74 3028 3 of of IN cord-015021-pol2qm74 3028 4 1001.tg/kg 1001.tg/kg NNP cord-015021-pol2qm74 3028 5 lipopolysaccharide lipopolysaccharide NN cord-015021-pol2qm74 3028 6 ( ( -LRB- cord-015021-pol2qm74 3028 7 LPS LPS NNP cord-015021-pol2qm74 3028 8 ) ) -RRB- cord-015021-pol2qm74 3028 9 , , , cord-015021-pol2qm74 3029 1 TNF tnf NN cord-015021-pol2qm74 3029 2 activity activity NN cord-015021-pol2qm74 3029 3 in in IN cord-015021-pol2qm74 3029 4 plasma plasma NN cord-015021-pol2qm74 3029 5 was be VBD cord-015021-pol2qm74 3029 6 suppressed suppress VBN cord-015021-pol2qm74 3029 7 by by IN cord-015021-pol2qm74 3029 8 food food NN cord-015021-pol2qm74 3029 9 restriction restriction NN cord-015021-pol2qm74 3029 10 but but CC cord-015021-pol2qm74 3029 11 there there EX cord-015021-pol2qm74 3029 12 were be VBD cord-015021-pol2qm74 3029 13 no no DT cord-015021-pol2qm74 3029 14 differences difference NNS cord-015021-pol2qm74 3029 15 between between IN cord-015021-pol2qm74 3029 16 sedentary sedentary JJ cord-015021-pol2qm74 3029 17 or or CC cord-015021-pol2qm74 3029 18 exercising exercise VBG cord-015021-pol2qm74 3029 19 rats rat NNS cord-015021-pol2qm74 3029 20 . . . cord-015021-pol2qm74 3030 1 In in IN cord-015021-pol2qm74 3030 2 addition addition NN cord-015021-pol2qm74 3030 3 , , , cord-015021-pol2qm74 3030 4 no no DT cord-015021-pol2qm74 3030 5 differences difference NNS cord-015021-pol2qm74 3030 6 were be VBD cord-015021-pol2qm74 3030 7 found find VBN cord-015021-pol2qm74 3030 8 among among IN cord-015021-pol2qm74 3030 9 groups group NNS cord-015021-pol2qm74 3030 10 for for IN cord-015021-pol2qm74 3030 11 corticosterone corticosterone NN cord-015021-pol2qm74 3030 12 , , , cord-015021-pol2qm74 3030 13 spleen spleen NNS cord-015021-pol2qm74 3030 14 IL il NN cord-015021-pol2qm74 3030 15 - - HYPH cord-015021-pol2qm74 3030 16 lc~ lc~ NN cord-015021-pol2qm74 3030 17 and and CC cord-015021-pol2qm74 3030 18 plasma plasma NN cord-015021-pol2qm74 3030 19 IL-6 IL-6 NNP cord-015021-pol2qm74 3030 20 activity activity NN cord-015021-pol2qm74 3030 21 . . . cord-015021-pol2qm74 3031 1 We -PRON- PRP cord-015021-pol2qm74 3031 2 conclude conclude VBP cord-015021-pol2qm74 3031 3 , , , cord-015021-pol2qm74 3031 4 that that IN cord-015021-pol2qm74 3031 5 the the DT cord-015021-pol2qm74 3031 6 food food NN cord-015021-pol2qm74 3031 7 restriction restriction NN cord-015021-pol2qm74 3031 8 - - HYPH cord-015021-pol2qm74 3031 9 induced induce VBN cord-015021-pol2qm74 3031 10 hyperactive hyperactive JJ cord-015021-pol2qm74 3031 11 rat rat NN cord-015021-pol2qm74 3031 12 model model NN cord-015021-pol2qm74 3031 13 is be VBZ cord-015021-pol2qm74 3031 14 a a DT cord-015021-pol2qm74 3031 15 useful useful JJ cord-015021-pol2qm74 3031 16 model model NN cord-015021-pol2qm74 3031 17 for for IN cord-015021-pol2qm74 3031 18 studies study NNS cord-015021-pol2qm74 3031 19 on on IN cord-015021-pol2qm74 3031 20 the the DT cord-015021-pol2qm74 3031 21 effects effect NNS cord-015021-pol2qm74 3031 22 of of IN cord-015021-pol2qm74 3031 23 chronic chronic JJ cord-015021-pol2qm74 3031 24 stress stress NN cord-015021-pol2qm74 3031 25 . . . cord-015021-pol2qm74 3032 1 In in IN cord-015021-pol2qm74 3032 2 this this DT cord-015021-pol2qm74 3032 3 model model NN cord-015021-pol2qm74 3032 4 , , , cord-015021-pol2qm74 3032 5 under under IN cord-015021-pol2qm74 3032 6 basal basal NN cord-015021-pol2qm74 3032 7 conditions condition NNS cord-015021-pol2qm74 3032 8 IL IL NNP cord-015021-pol2qm74 3032 9 - - HYPH cord-015021-pol2qm74 3032 10 le~ le~ NN cord-015021-pol2qm74 3032 11 in in IN cord-015021-pol2qm74 3032 12 tissues tissue NNS cord-015021-pol2qm74 3032 13 may may MD cord-015021-pol2qm74 3032 14 be be VB cord-015021-pol2qm74 3032 15 subject subject JJ cord-015021-pol2qm74 3032 16 to to IN cord-015021-pol2qm74 3032 17 downregulation downregulation NN cord-015021-pol2qm74 3032 18 by by IN cord-015021-pol2qm74 3032 19 glucocorticoids glucocorticoid NNS cord-015021-pol2qm74 3032 20 , , , cord-015021-pol2qm74 3032 21 whereas whereas IN cord-015021-pol2qm74 3032 22 after after IN cord-015021-pol2qm74 3032 23 LPS lps NN cord-015021-pol2qm74 3032 24 - - HYPH cord-015021-pol2qm74 3032 25 stimulation stimulation NN cord-015021-pol2qm74 3032 26 of of IN cord-015021-pol2qm74 3032 27 cytokine cytokine NN cord-015021-pol2qm74 3032 28 production production NN cord-015021-pol2qm74 3032 29 only only RB cord-015021-pol2qm74 3032 30 TNF TNF NNP cord-015021-pol2qm74 3032 31 activity activity NN cord-015021-pol2qm74 3032 32 is be VBZ cord-015021-pol2qm74 3032 33 regulated regulate VBN cord-015021-pol2qm74 3032 34 by by IN cord-015021-pol2qm74 3032 35 fast fast JJ cord-015021-pol2qm74 3032 36 acting acting NN cord-015021-pol2qm74 3032 37 feedback feedback NN cord-015021-pol2qm74 3032 38 loop loop NN cord-015021-pol2qm74 3032 39 between between IN cord-015021-pol2qm74 3032 40 cytokines cytokine NNS cord-015021-pol2qm74 3032 41 and and CC cord-015021-pol2qm74 3032 42 the the DT cord-015021-pol2qm74 3032 43 hypothalamo hypothalamo JJ cord-015021-pol2qm74 3032 44 - - HYPH cord-015021-pol2qm74 3032 45 pituitary pituitary NN cord-015021-pol2qm74 3032 46 - - HYPH cord-015021-pol2qm74 3032 47 adrenal adrenal NN cord-015021-pol2qm74 3032 48 axis axis NN cord-015021-pol2qm74 3032 49 ( ( -LRB- cord-015021-pol2qm74 3032 50 HPA HPA NNP cord-015021-pol2qm74 3032 51 - - HYPH cord-015021-pol2qm74 3032 52 axis axis NN cord-015021-pol2qm74 3032 53 ) ) -RRB- cord-015021-pol2qm74 3032 54 . . . cord-015021-pol2qm74 3033 1 This this DT cord-015021-pol2qm74 3033 2 is be VBZ cord-015021-pol2qm74 3033 3 supported support VBN cord-015021-pol2qm74 3033 4 by by IN cord-015021-pol2qm74 3033 5 strong strong JJ cord-015021-pol2qm74 3033 6 correlations correlation NNS cord-015021-pol2qm74 3033 7 between between IN cord-015021-pol2qm74 3033 8 plasma plasma NN cord-015021-pol2qm74 3033 9 TNF TNF NNP cord-015021-pol2qm74 3033 10 activity activity NN cord-015021-pol2qm74 3033 11 and and CC cord-015021-pol2qm74 3033 12 corticosterone corticosterone NN cord-015021-pol2qm74 3033 13 in in IN cord-015021-pol2qm74 3033 14 stressed stressed JJ cord-015021-pol2qm74 3033 15 rats rat NNS cord-015021-pol2qm74 3033 16 . . . cord-015021-pol2qm74 3034 1 Cytokine cytokine NN cord-015021-pol2qm74 3034 2 antagonists antagonist NNS cord-015021-pol2qm74 3034 3 modulate modulate VBP cord-015021-pol2qm74 3034 4 cytokine cytokine JJ cord-015021-pol2qm74 3034 5 actions action NNS cord-015021-pol2qm74 3034 6 and and CC cord-015021-pol2qm74 3034 7 it -PRON- PRP cord-015021-pol2qm74 3034 8 appears appear VBZ cord-015021-pol2qm74 3034 9 that that IN cord-015021-pol2qm74 3034 10 a a DT cord-015021-pol2qm74 3034 11 balance balance NN cord-015021-pol2qm74 3034 12 between between IN cord-015021-pol2qm74 3034 13 production production NN cord-015021-pol2qm74 3034 14 of of IN cord-015021-pol2qm74 3034 15 cytokines cytokine NNS cord-015021-pol2qm74 3034 16 and and CC cord-015021-pol2qm74 3034 17 cytokine cytokine NN cord-015021-pol2qm74 3034 18 antagonists antagonist NNS cord-015021-pol2qm74 3034 19 is be VBZ cord-015021-pol2qm74 3034 20 important important JJ cord-015021-pol2qm74 3034 21 to to TO cord-015021-pol2qm74 3034 22 control control NN cord-015021-pol2qm74 3034 23 of of IN cord-015021-pol2qm74 3034 24 host host NN cord-015021-pol2qm74 3034 25 responses response NNS cord-015021-pol2qm74 3034 26 . . . cord-015021-pol2qm74 3035 1 Recent recent JJ cord-015021-pol2qm74 3035 2 observations observation NNS cord-015021-pol2qm74 3035 3 show show VBP cord-015021-pol2qm74 3035 4 that that IN cord-015021-pol2qm74 3035 5 during during IN cord-015021-pol2qm74 3035 6 myocardial myocardial JJ cord-015021-pol2qm74 3035 7 infarction infarction NN cord-015021-pol2qm74 3035 8 there there EX cord-015021-pol2qm74 3035 9 is be VBZ cord-015021-pol2qm74 3035 10 an an DT cord-015021-pol2qm74 3035 11 increase increase NN cord-015021-pol2qm74 3035 12 in in IN cord-015021-pol2qm74 3035 13 circulating circulate VBG cord-015021-pol2qm74 3035 14 cytokines cytokine NNS cord-015021-pol2qm74 3035 15 such such JJ cord-015021-pol2qm74 3035 16 as as IN cord-015021-pol2qm74 3035 17 tumor tumor NN cord-015021-pol2qm74 3035 18 necrosis necrosis NN cord-015021-pol2qm74 3035 19 factor factor NN cord-015021-pol2qm74 3035 20 ( ( -LRB- cord-015021-pol2qm74 3035 21 TNF TNF NNP cord-015021-pol2qm74 3035 22 ) ) -RRB- cord-015021-pol2qm74 3035 23 and and CC cord-015021-pol2qm74 3035 24 interleukin interleukin NN cord-015021-pol2qm74 3035 25 6 6 CD cord-015021-pol2qm74 3035 26 ( ( -LRB- cord-015021-pol2qm74 3035 27 IL-6 IL-6 NNP cord-015021-pol2qm74 3035 28 ) ) -RRB- cord-015021-pol2qm74 3035 29 . . . cord-015021-pol2qm74 3036 1 We -PRON- PRP cord-015021-pol2qm74 3036 2 tested test VBD cord-015021-pol2qm74 3036 3 the the DT cord-015021-pol2qm74 3036 4 idea idea NN cord-015021-pol2qm74 3036 5 that that IN cord-015021-pol2qm74 3036 6 compensatory compensatory JJ cord-015021-pol2qm74 3036 7 increases increase NNS cord-015021-pol2qm74 3036 8 in in IN cord-015021-pol2qm74 3036 9 cytokine cytokine NN cord-015021-pol2qm74 3036 10 antagonists antagonist NNS cord-015021-pol2qm74 3036 11 likewise likewise RB cord-015021-pol2qm74 3036 12 occur occur VBP cord-015021-pol2qm74 3036 13 and and CC cord-015021-pol2qm74 3036 14 investigated investigate VBN cord-015021-pol2qm74 3036 15 changes change NNS cord-015021-pol2qm74 3036 16 in in IN cord-015021-pol2qm74 3036 17 plasma plasma NN cord-015021-pol2qm74 3036 18 concentrations concentration NNS cord-015021-pol2qm74 3036 19 of of IN cord-015021-pol2qm74 3036 20 TNF TNF NNP cord-015021-pol2qm74 3036 21 and and CC cord-015021-pol2qm74 3036 22 interleukin interleukin NN cord-015021-pol2qm74 3036 23 i i NNP cord-015021-pol2qm74 3036 24 ( ( -LRB- cord-015021-pol2qm74 3036 25 IL-1 IL-1 NNP cord-015021-pol2qm74 3036 26 ) ) -RRB- cord-015021-pol2qm74 3036 27 and and CC cord-015021-pol2qm74 3036 28 those those DT cord-015021-pol2qm74 3036 29 of of IN cord-015021-pol2qm74 3036 30 their -PRON- PRP$ cord-015021-pol2qm74 3036 31 specific specific JJ cord-015021-pol2qm74 3036 32 antagonists antagonist NNS cord-015021-pol2qm74 3036 33 interleukin-1 interleukin-1 NNP cord-015021-pol2qm74 3036 34 receptor receptor NN cord-015021-pol2qm74 3036 35 antagonist antagonist NN cord-015021-pol2qm74 3036 36 ( ( -LRB- cord-015021-pol2qm74 3036 37 IL-1 IL-1 NNP cord-015021-pol2qm74 3036 38 ra ra NNP cord-015021-pol2qm74 3036 39 ) ) -RRB- cord-015021-pol2qm74 3036 40 and and CC cord-015021-pol2qm74 3036 41 soluble soluble JJ cord-015021-pol2qm74 3036 42 tumor tumor NN cord-015021-pol2qm74 3036 43 necrosis necrosis NN cord-015021-pol2qm74 3036 44 factor factor NN cord-015021-pol2qm74 3036 45 receptor receptor NN cord-015021-pol2qm74 3036 46 type type NN cord-015021-pol2qm74 3036 47 I -PRON- PRP cord-015021-pol2qm74 3036 48 ( ( -LRB- cord-015021-pol2qm74 3036 49 s s VBZ cord-015021-pol2qm74 3036 50 TNF TNF NNP cord-015021-pol2qm74 3036 51 r r NN cord-015021-pol2qm74 3036 52 - - : cord-015021-pol2qm74 3036 53 I I NNP cord-015021-pol2qm74 3036 54 ) ) -RRB- cord-015021-pol2qm74 3036 55 . . . cord-015021-pol2qm74 3037 1 We -PRON- PRP cord-015021-pol2qm74 3037 2 also also RB cord-015021-pol2qm74 3037 3 measured measure VBD cord-015021-pol2qm74 3037 4 plasma plasma NN cord-015021-pol2qm74 3037 5 concentrations concentration NNS cord-015021-pol2qm74 3037 6 of of IN cord-015021-pol2qm74 3037 7 ~-melanocyte ~-melanocyte RB cord-015021-pol2qm74 3037 8 - - HYPH cord-015021-pol2qm74 3037 9 stimulating stimulate VBG cord-015021-pol2qm74 3037 10 hormone hormone NN cord-015021-pol2qm74 3037 11 ( ( -LRB- cord-015021-pol2qm74 3037 12 ~-MSH ~-MSH NNP cord-015021-pol2qm74 3037 13 ) ) -RRB- cord-015021-pol2qm74 3037 14 , , , cord-015021-pol2qm74 3037 15 an an DT cord-015021-pol2qm74 3037 16 endogenous endogenous JJ cord-015021-pol2qm74 3037 17 neuropeptide neuropeptide NN cord-015021-pol2qm74 3037 18 that that WDT cord-015021-pol2qm74 3037 19 occurs occur VBZ cord-015021-pol2qm74 3037 20 in in IN cord-015021-pol2qm74 3037 21 pituitary pituitary NN cord-015021-pol2qm74 3037 22 , , , cord-015021-pol2qm74 3037 23 brain brain NN cord-015021-pol2qm74 3037 24 , , , cord-015021-pol2qm74 3037 25 skin skin NN cord-015021-pol2qm74 3037 26 , , , cord-015021-pol2qm74 3037 27 gut gut NN cord-015021-pol2qm74 3037 28 and and CC cord-015021-pol2qm74 3037 29 other other JJ cord-015021-pol2qm74 3037 30 tissues tissue NNS cord-015021-pol2qm74 3037 31 . . . cord-015021-pol2qm74 3038 1 When when WRB cord-015021-pol2qm74 3038 2 administered administer VBN cord-015021-pol2qm74 3038 3 to to IN cord-015021-pol2qm74 3038 4 laboratory laboratory NN cord-015021-pol2qm74 3038 5 animals animal NNS cord-015021-pol2qm74 3038 6 , , , cord-015021-pol2qm74 3038 7 this this DT cord-015021-pol2qm74 3038 8 peptide peptide NN cord-015021-pol2qm74 3038 9 has have VBZ cord-015021-pol2qm74 3038 10 potent potent JJ cord-015021-pol2qm74 3038 11 antiinflammatory antiinflammatory JJ cord-015021-pol2qm74 3038 12 and and CC cord-015021-pol2qm74 3038 13 antipyretic antipyretic JJ cord-015021-pol2qm74 3038 14 activity activity NN cord-015021-pol2qm74 3038 15 , , , cord-015021-pol2qm74 3038 16 perhaps perhaps RB cord-015021-pol2qm74 3038 17 by by IN cord-015021-pol2qm74 3038 18 mimicking mimic VBG cord-015021-pol2qm74 3038 19 an an DT cord-015021-pol2qm74 3038 20 endogenous endogenous JJ cord-015021-pol2qm74 3038 21 modulatory modulatory JJ cord-015021-pol2qm74 3038 22 influence influence NN cord-015021-pol2qm74 3038 23 on on IN cord-015021-pol2qm74 3038 24 cytokine cytokine JJ cord-015021-pol2qm74 3038 25 actions action NNS cord-015021-pol2qm74 3038 26 . . . cord-015021-pol2qm74 3039 1 Samples sample NNS cord-015021-pol2qm74 3039 2 were be VBD cord-015021-pol2qm74 3039 3 obtained obtain VBN cord-015021-pol2qm74 3039 4 from from IN cord-015021-pol2qm74 3039 5 20 20 CD cord-015021-pol2qm74 3039 6 patients patient NNS cord-015021-pol2qm74 3039 7 with with IN cord-015021-pol2qm74 3039 8 acute acute JJ cord-015021-pol2qm74 3039 9 myocardial myocardial JJ cord-015021-pol2qm74 3039 10 infarction infarction NN cord-015021-pol2qm74 3039 11 at at IN cord-015021-pol2qm74 3039 12 presentation presentation NN cord-015021-pol2qm74 3039 13 in in IN cord-015021-pol2qm74 3039 14 the the DT cord-015021-pol2qm74 3039 15 Coronary Coronary NNP cord-015021-pol2qm74 3039 16 Unit Unit NNP cord-015021-pol2qm74 3039 17 , , , cord-015021-pol2qm74 3039 18 every every DT cord-015021-pol2qm74 3039 19 three three CD cord-015021-pol2qm74 3039 20 hours hour NNS cord-015021-pol2qm74 3039 21 for for IN cord-015021-pol2qm74 3039 22 24 24 CD cord-015021-pol2qm74 3039 23 hours hour NNS cord-015021-pol2qm74 3039 24 , , , cord-015021-pol2qm74 3039 25 and and CC cord-015021-pol2qm74 3039 26 daily daily RB cord-015021-pol2qm74 3039 27 thereafter thereafter RB cord-015021-pol2qm74 3039 28 until until IN cord-015021-pol2qm74 3039 29 discharge discharge NN cord-015021-pol2qm74 3039 30 . . . cord-015021-pol2qm74 3040 1 We -PRON- PRP cord-015021-pol2qm74 3040 2 found find VBD cord-015021-pol2qm74 3040 3 elevations elevation NNS cord-015021-pol2qm74 3040 4 in in IN cord-015021-pol2qm74 3040 5 the the DT cord-015021-pol2qm74 3040 6 plasma plasma NN cord-015021-pol2qm74 3040 7 cytokines cytokine NNS cord-015021-pol2qm74 3040 8 IL-1 IL-1 NNP cord-015021-pol2qm74 3040 9 and and CC cord-015021-pol2qm74 3040 10 TNF TNF NNP cord-015021-pol2qm74 3040 11 only only RB cord-015021-pol2qm74 3040 12 in in IN cord-015021-pol2qm74 3040 13 a a DT cord-015021-pol2qm74 3040 14 proportion proportion NN cord-015021-pol2qm74 3040 15 of of IN cord-015021-pol2qm74 3040 16 subjects subject NNS cord-015021-pol2qm74 3040 17 whereas whereas IN cord-015021-pol2qm74 3040 18 cytokine cytokine NN cord-015021-pol2qm74 3040 19 antagonists antagonist NNS cord-015021-pol2qm74 3040 20 c~-MSH c~-msh VBP cord-015021-pol2qm74 3040 21 , , , cord-015021-pol2qm74 3040 22 IL IL NNP cord-015021-pol2qm74 3040 23 - - HYPH cord-015021-pol2qm74 3040 24 lra lra NNP cord-015021-pol2qm74 3040 25 , , , cord-015021-pol2qm74 3040 26 and and CC cord-015021-pol2qm74 3040 27 sTNFr stnfr CD cord-015021-pol2qm74 3040 28 were be VBD cord-015021-pol2qm74 3040 29 elevated elevate VBN cord-015021-pol2qm74 3040 30 in in IN cord-015021-pol2qm74 3040 31 all all DT cord-015021-pol2qm74 3040 32 patients patient NNS cord-015021-pol2qm74 3040 33 , , , cord-015021-pol2qm74 3040 34 o~-MSH o~-MSH NNP cord-015021-pol2qm74 3040 35 was be VBD cord-015021-pol2qm74 3040 36 elevated elevate VBN cord-015021-pol2qm74 3040 37 at at IN cord-015021-pol2qm74 3040 38 presentation presentation NN cord-015021-pol2qm74 3040 39 but but CC cord-015021-pol2qm74 3040 40 it -PRON- PRP cord-015021-pol2qm74 3040 41 decreased decrease VBD cord-015021-pol2qm74 3040 42 progressively progressively RB cord-015021-pol2qm74 3040 43 in in IN cord-015021-pol2qm74 3040 44 successive successive JJ cord-015021-pol2qm74 3040 45 tests test NNS cord-015021-pol2qm74 3040 46 , , , cord-015021-pol2qm74 3040 47 reaching reach VBG cord-015021-pol2qm74 3040 48 normal normal JJ cord-015021-pol2qm74 3040 49 values value NNS cord-015021-pol2qm74 3040 50 within within IN cord-015021-pol2qm74 3040 51 24 24 CD cord-015021-pol2qm74 3040 52 hr hr NN cord-015021-pol2qm74 3040 53 whereas whereas IN cord-015021-pol2qm74 3040 54 sTNFr stnfr XX cord-015021-pol2qm74 3040 55 and and CC cord-015021-pol2qm74 3040 56 1L 1l CD cord-015021-pol2qm74 3040 57 - - HYPH cord-015021-pol2qm74 3040 58 lra lra NNP cord-015021-pol2qm74 3040 59 peaked peak VBD cord-015021-pol2qm74 3040 60 at at IN cord-015021-pol2qm74 3040 61 3 3 CD cord-015021-pol2qm74 3040 62 - - SYM cord-015021-pol2qm74 3040 63 6 6 CD cord-015021-pol2qm74 3040 64 hr hr NN cord-015021-pol2qm74 3040 65 or or CC cord-015021-pol2qm74 3040 66 later later RB cord-015021-pol2qm74 3040 67 . . . cord-015021-pol2qm74 3041 1 There there EX cord-015021-pol2qm74 3041 2 were be VBD cord-015021-pol2qm74 3041 3 significant significant JJ cord-015021-pol2qm74 3041 4 correlations correlation NNS cord-015021-pol2qm74 3041 5 between between IN cord-015021-pol2qm74 3041 6 plasma plasma NN cord-015021-pol2qm74 3041 7 concentrations concentration NNS cord-015021-pol2qm74 3041 8 of of IN cord-015021-pol2qm74 3041 9 cytokine cytokine JJ cord-015021-pol2qm74 3041 10 antagonists antagonist NNS cord-015021-pol2qm74 3041 11 and and CC cord-015021-pol2qm74 3041 12 enzymes enzyme NNS cord-015021-pol2qm74 3041 13 released release VBN cord-015021-pol2qm74 3041 14 from from IN cord-015021-pol2qm74 3041 15 injured injured JJ cord-015021-pol2qm74 3041 16 myocardium myocardium NN cord-015021-pol2qm74 3041 17 , , , cord-015021-pol2qm74 3041 18 including include VBG cord-015021-pol2qm74 3041 19 creatine creatine NN cord-015021-pol2qm74 3041 20 kinase kinase NN cord-015021-pol2qm74 3041 21 ( ( -LRB- cord-015021-pol2qm74 3041 22 CK CK NNP cord-015021-pol2qm74 3041 23 ) ) -RRB- cord-015021-pol2qm74 3041 24 , , , cord-015021-pol2qm74 3041 25 aspartate aspartate NN cord-015021-pol2qm74 3041 26 serum serum NN cord-015021-pol2qm74 3041 27 transferase transferase NN cord-015021-pol2qm74 3041 28 ( ( -LRB- cord-015021-pol2qm74 3041 29 AST AST NNP cord-015021-pol2qm74 3041 30 ) ) -RRB- cord-015021-pol2qm74 3041 31 , , , cord-015021-pol2qm74 3041 32 and and CC cord-015021-pol2qm74 3041 33 lactate lactate NN cord-015021-pol2qm74 3041 34 dehydrogenase dehydrogenase NN cord-015021-pol2qm74 3041 35 ( ( -LRB- cord-015021-pol2qm74 3041 36 LDH LDH NNP cord-015021-pol2qm74 3041 37 ) ) -RRB- cord-015021-pol2qm74 3041 38 . . . cord-015021-pol2qm74 3042 1 The the DT cord-015021-pol2qm74 3042 2 data datum NNS cord-015021-pol2qm74 3042 3 show show VBP cord-015021-pol2qm74 3042 4 that that IN cord-015021-pol2qm74 3042 5 cytokine cytokine NN cord-015021-pol2qm74 3042 6 antagonists antagonist NNS cord-015021-pol2qm74 3042 7 increase increase VBP cord-015021-pol2qm74 3042 8 in in IN cord-015021-pol2qm74 3042 9 the the DT cord-015021-pol2qm74 3042 10 circulation circulation NN cord-015021-pol2qm74 3042 11 of of IN cord-015021-pol2qm74 3042 12 patients patient NNS cord-015021-pol2qm74 3042 13 with with IN cord-015021-pol2qm74 3042 14 acute acute JJ cord-015021-pol2qm74 3042 15 myocardial myocardial JJ cord-015021-pol2qm74 3042 16 infarction infarction NN cord-015021-pol2qm74 3042 17 likely likely JJ cord-015021-pol2qm74 3042 18 to to TO cord-015021-pol2qm74 3042 19 modulate modulate VB cord-015021-pol2qm74 3042 20 prninflammatory prninflammatory NN cord-015021-pol2qm74 3042 21 effects effect NNS cord-015021-pol2qm74 3042 22 of of IN cord-015021-pol2qm74 3042 23 cytokines cytokine NNS cord-015021-pol2qm74 3042 24 . . . cord-015021-pol2qm74 3043 1 Objects object NNS cord-015021-pol2qm74 3043 2 of of IN cord-015021-pol2qm74 3043 3 the the DT cord-015021-pol2qm74 3043 4 study study NN cord-015021-pol2qm74 3043 5 : : : cord-015021-pol2qm74 3043 6 Interleukin-6 Interleukin-6 NNP cord-015021-pol2qm74 3043 7 ( ( -LRB- cord-015021-pol2qm74 3043 8 IL-6 IL-6 NNP cord-015021-pol2qm74 3043 9 ) ) -RRB- cord-015021-pol2qm74 3043 10 is be VBZ cord-015021-pol2qm74 3043 11 a a DT cord-015021-pol2qm74 3043 12 multifunctionai multifunctionai JJ cord-015021-pol2qm74 3043 13 cytokine cytokine NN cord-015021-pol2qm74 3043 14 known know VBN cord-015021-pol2qm74 3043 15 to to TO cord-015021-pol2qm74 3043 16 be be VB cord-015021-pol2qm74 3043 17 involved involve VBN cord-015021-pol2qm74 3043 18 in in IN cord-015021-pol2qm74 3043 19 important important JJ cord-015021-pol2qm74 3043 20 homeostatic homeostatic JJ cord-015021-pol2qm74 3043 21 processes process NNS cord-015021-pol2qm74 3043 22 . . . cord-015021-pol2qm74 3044 1 IL-6 IL-6 NNP cord-015021-pol2qm74 3044 2 levels level NNS cord-015021-pol2qm74 3044 3 are be VBP cord-015021-pol2qm74 3044 4 increased increase VBN cord-015021-pol2qm74 3044 5 in in IN cord-015021-pol2qm74 3044 6 many many JJ cord-015021-pol2qm74 3044 7 pathological pathological JJ cord-015021-pol2qm74 3044 8 situations situation NNS cord-015021-pol2qm74 3044 9 , , , cord-015021-pol2qm74 3044 10 and and CC cord-015021-pol2qm74 3044 11 correlates correlate VBZ cord-015021-pol2qm74 3044 12 with with IN cord-015021-pol2qm74 3044 13 disease disease NN cord-015021-pol2qm74 3044 14 activity activity NN cord-015021-pol2qm74 3044 15 and and CC cord-015021-pol2qm74 3044 16 patient patient NN cord-015021-pol2qm74 3044 17 outcome outcome NN cord-015021-pol2qm74 3044 18 . . . cord-015021-pol2qm74 3045 1 To to TO cord-015021-pol2qm74 3045 2 exert exert VB cord-015021-pol2qm74 3045 3 its -PRON- PRP$ cord-015021-pol2qm74 3045 4 effect effect NN cord-015021-pol2qm74 3045 5 IL-6 IL-6 NNP cord-015021-pol2qm74 3045 6 binds bind VBZ cord-015021-pol2qm74 3045 7 to to IN cord-015021-pol2qm74 3045 8 its -PRON- PRP$ cord-015021-pol2qm74 3045 9 receptor receptor NN cord-015021-pol2qm74 3045 10 on on IN cord-015021-pol2qm74 3045 11 the the DT cord-015021-pol2qm74 3045 12 membrane membrane NN cord-015021-pol2qm74 3045 13 of of IN cord-015021-pol2qm74 3045 14 its -PRON- PRP$ cord-015021-pol2qm74 3045 15 target target NN cord-015021-pol2qm74 3045 16 cell cell NN cord-015021-pol2qm74 3045 17 . . . cord-015021-pol2qm74 3046 1 This this DT cord-015021-pol2qm74 3046 2 receptor receptor NN cord-015021-pol2qm74 3046 3 is be VBZ cord-015021-pol2qm74 3046 4 also also RB cord-015021-pol2qm74 3046 5 present present JJ cord-015021-pol2qm74 3046 6 in in IN cord-015021-pol2qm74 3046 7 a a DT cord-015021-pol2qm74 3046 8 soluble soluble JJ cord-015021-pol2qm74 3046 9 form form NN cord-015021-pol2qm74 3046 10 in in IN cord-015021-pol2qm74 3046 11 plasma plasma NN cord-015021-pol2qm74 3046 12 and and CC cord-015021-pol2qm74 3046 13 in in IN cord-015021-pol2qm74 3046 14 urine urine NN cord-015021-pol2qm74 3046 15 . . . cord-015021-pol2qm74 3047 1 In in IN cord-015021-pol2qm74 3047 2 this this DT cord-015021-pol2qm74 3047 3 study study NN cord-015021-pol2qm74 3047 4 we -PRON- PRP cord-015021-pol2qm74 3047 5 quantitatively quantitatively RB cord-015021-pol2qm74 3047 6 measured measure VBD cord-015021-pol2qm74 3047 7 the the DT cord-015021-pol2qm74 3047 8 availability availability NN cord-015021-pol2qm74 3047 9 of of IN cord-015021-pol2qm74 3047 10 soluble soluble JJ cord-015021-pol2qm74 3047 11 IL-6 IL-6 NNP cord-015021-pol2qm74 3047 12 receptor receptor NN cord-015021-pol2qm74 3047 13 ( ( -LRB- cord-015021-pol2qm74 3047 14 slL-6R slL-6R NNS cord-015021-pol2qm74 3047 15 ) ) -RRB- cord-015021-pol2qm74 3047 16 in in IN cord-015021-pol2qm74 3047 17 biological biological JJ cord-015021-pol2qm74 3047 18 fluids fluid NNS cord-015021-pol2qm74 3047 19 in in IN cord-015021-pol2qm74 3047 20 healthy healthy JJ cord-015021-pol2qm74 3047 21 volunteers volunteer NNS cord-015021-pol2qm74 3047 22 . . . cord-015021-pol2qm74 3048 1 Materials material NNS cord-015021-pol2qm74 3048 2 and and CC cord-015021-pol2qm74 3048 3 methods method NNS cord-015021-pol2qm74 3048 4 : : : cord-015021-pol2qm74 3048 5 Blood blood NN cord-015021-pol2qm74 3048 6 , , , cord-015021-pol2qm74 3048 7 urine urine NN cord-015021-pol2qm74 3048 8 , , , cord-015021-pol2qm74 3048 9 cerebrospinal cerebrospinal JJ cord-015021-pol2qm74 3048 10 fluid fluid NN cord-015021-pol2qm74 3048 11 ( ( -LRB- cord-015021-pol2qm74 3048 12 CSF CSF NNP cord-015021-pol2qm74 3048 13 ) ) -RRB- cord-015021-pol2qm74 3048 14 , , , cord-015021-pol2qm74 3048 15 and and CC cord-015021-pol2qm74 3048 16 synovial synovial JJ cord-015021-pol2qm74 3048 17 fluid fluid NN cord-015021-pol2qm74 3048 18 ( ( -LRB- cord-015021-pol2qm74 3048 19 SF SF NNP cord-015021-pol2qm74 3048 20 ) ) -RRB- cord-015021-pol2qm74 3048 21 are be VBP cord-015021-pol2qm74 3048 22 obtained obtain VBN cord-015021-pol2qm74 3048 23 from from IN cord-015021-pol2qm74 3048 24 healthy healthy JJ cord-015021-pol2qm74 3048 25 volunteers volunteer NNS cord-015021-pol2qm74 3048 26 , , , cord-015021-pol2qm74 3048 27 sIL-6R sIL-6R NNP cord-015021-pol2qm74 3048 28 and and CC cord-015021-pol2qm74 3048 29 IL-6 IL-6 NNP cord-015021-pol2qm74 3048 30 are be VBP cord-015021-pol2qm74 3048 31 measured measure VBN cord-015021-pol2qm74 3048 32 using use VBG cord-015021-pol2qm74 3048 33 ELISA ELISA NNP cord-015021-pol2qm74 3048 34 's 's POS cord-015021-pol2qm74 3048 35 . . . cord-015021-pol2qm74 3049 1 Both both DT cord-015021-pol2qm74 3049 2 ELISA ELISA NNP cord-015021-pol2qm74 3049 3 's 's POS cord-015021-pol2qm74 3049 4 are be VBP cord-015021-pol2qm74 3049 5 tested test VBN cord-015021-pol2qm74 3049 6 for for IN cord-015021-pol2qm74 3049 7 interference interference NN cord-015021-pol2qm74 3049 8 of of IN cord-015021-pol2qm74 3049 9 sIL-6R sil-6r NN cord-015021-pol2qm74 3049 10 mid mid NNP cord-015021-pol2qm74 3049 11 IL-6 IL-6 NNP cord-015021-pol2qm74 3049 12 . . . cord-015021-pol2qm74 3050 1 The the DT cord-015021-pol2qm74 3050 2 effect effect NN cord-015021-pol2qm74 3050 3 of of IN cord-015021-pol2qm74 3050 4 slL-6R slL-6R NNS cord-015021-pol2qm74 3050 5 in in IN cord-015021-pol2qm74 3050 6 the the DT cord-015021-pol2qm74 3050 7 IL-6 IL-6 NNP cord-015021-pol2qm74 3050 8 bio bio NN cord-015021-pol2qm74 3050 9 - - HYPH cord-015021-pol2qm74 3050 10 assay assay NNP cord-015021-pol2qm74 3050 11 ( ( -LRB- cord-015021-pol2qm74 3050 12 B9 B9 NNP cord-015021-pol2qm74 3050 13 ) ) -RRB- cord-015021-pol2qm74 3050 14 is be VBZ cord-015021-pol2qm74 3050 15 tested test VBN cord-015021-pol2qm74 3050 16 . . . cord-015021-pol2qm74 3051 1 Results result NNS cord-015021-pol2qm74 3051 2 : : : cord-015021-pol2qm74 3052 1 Baseline baseline JJ cord-015021-pol2qm74 3052 2 levels level NNS cord-015021-pol2qm74 3052 3 are be VBP cord-015021-pol2qm74 3052 4 ( ( -LRB- cord-015021-pol2qm74 3052 5 mean mean VB cord-015021-pol2qm74 3052 6 + + CC cord-015021-pol2qm74 3052 7 SD sd NN cord-015021-pol2qm74 3052 8 ) ) -RRB- cord-015021-pol2qm74 3052 9 : : : cord-015021-pol2qm74 3052 10 76.6 76.6 CD cord-015021-pol2qm74 3052 11 -+ -+ NNP cord-015021-pol2qm74 3052 12 19.3 19.3 CD cord-015021-pol2qm74 3052 13 ng ng NNP cord-015021-pol2qm74 3052 14 / / SYM cord-015021-pol2qm74 3052 15 ml ml NN cord-015021-pol2qm74 3052 16 in in IN cord-015021-pol2qm74 3052 17 serum serum NN cord-015021-pol2qm74 3052 18 , , , cord-015021-pol2qm74 3052 19 3.7 3.7 CD cord-015021-pol2qm74 3052 20 -+ -+ NFP cord-015021-pol2qm74 3052 21 1.3 1.3 CD cord-015021-pol2qm74 3052 22 ng ng NN cord-015021-pol2qm74 3052 23 / / SYM cord-015021-pol2qm74 3052 24 ml ml NN cord-015021-pol2qm74 3052 25 in in IN cord-015021-pol2qm74 3052 26 urine urine NN cord-015021-pol2qm74 3052 27 , , , cord-015021-pol2qm74 3052 28 1.64 1.64 CD cord-015021-pol2qm74 3052 29 _ _ NN cord-015021-pol2qm74 3052 30 + + SYM cord-015021-pol2qm74 3052 31 0.4 0.4 CD cord-015021-pol2qm74 3052 32 ng ng NN cord-015021-pol2qm74 3052 33 / / SYM cord-015021-pol2qm74 3052 34 ml ml NN cord-015021-pol2qm74 3052 35 in in IN cord-015021-pol2qm74 3052 36 CSF CSF NNP cord-015021-pol2qm74 3052 37 and and CC cord-015021-pol2qm74 3052 38 11.6 11.6 CD cord-015021-pol2qm74 3052 39 + + SYM cord-015021-pol2qm74 3052 40 3.3 3.3 CD cord-015021-pol2qm74 3052 41 ng ng NN cord-015021-pol2qm74 3052 42 / / SYM cord-015021-pol2qm74 3052 43 ml ml NN cord-015021-pol2qm74 3052 44 in in IN cord-015021-pol2qm74 3052 45 SF SF NNP cord-015021-pol2qm74 3052 46 . . . cord-015021-pol2qm74 3053 1 There there EX cord-015021-pol2qm74 3053 2 is be VBZ cord-015021-pol2qm74 3053 3 no no DT cord-015021-pol2qm74 3053 4 interference interference NN cord-015021-pol2qm74 3053 5 of of IN cord-015021-pol2qm74 3053 6 slL-6R slL-6R NNS cord-015021-pol2qm74 3053 7 in in IN cord-015021-pol2qm74 3053 8 the the DT cord-015021-pol2qm74 3053 9 IL-6 IL-6 NNP cord-015021-pol2qm74 3053 10 ELISA ELISA NNP cord-015021-pol2qm74 3053 11 or or CC cord-015021-pol2qm74 3053 12 bio bio NN cord-015021-pol2qm74 3053 13 - - HYPH cord-015021-pol2qm74 3053 14 assay assay NN cord-015021-pol2qm74 3053 15 and and CC cord-015021-pol2qm74 3053 16 no no DT cord-015021-pol2qm74 3053 17 interference interference NN cord-015021-pol2qm74 3053 18 of of IN cord-015021-pol2qm74 3053 19 1L-6 1l-6 CD cord-015021-pol2qm74 3053 20 in in IN cord-015021-pol2qm74 3053 21 the the DT cord-015021-pol2qm74 3053 22 sIL-6R sil-6r NN cord-015021-pol2qm74 3053 23 ELISA ELISA NNP cord-015021-pol2qm74 3053 24 . . . cord-015021-pol2qm74 3054 1 Conclusions conclusion NNS cord-015021-pol2qm74 3054 2 : : : cord-015021-pol2qm74 3055 1 In in IN cord-015021-pol2qm74 3055 2 all all DT cord-015021-pol2qm74 3055 3 investigated investigate VBN cord-015021-pol2qm74 3055 4 biological biological JJ cord-015021-pol2qm74 3055 5 fluids fluid NNS cord-015021-pol2qm74 3055 6 slL-6R slL-6R NNS cord-015021-pol2qm74 3055 7 can can MD cord-015021-pol2qm74 3055 8 be be VB cord-015021-pol2qm74 3055 9 found find VBN cord-015021-pol2qm74 3055 10 . . . cord-015021-pol2qm74 3056 1 These these DT cord-015021-pol2qm74 3056 2 data datum NNS cord-015021-pol2qm74 3056 3 provide provide VBP cord-015021-pol2qm74 3056 4 baseline baseline JJ cord-015021-pol2qm74 3056 5 values value NNS cord-015021-pol2qm74 3056 6 for for IN cord-015021-pol2qm74 3056 7 investigations investigation NNS cord-015021-pol2qm74 3056 8 concerning concern VBG cord-015021-pol2qm74 3056 9 pathological pathological JJ cord-015021-pol2qm74 3056 10 situations situation NNS cord-015021-pol2qm74 3056 11 . . . cord-015021-pol2qm74 3057 1 Both both DT cord-015021-pol2qm74 3057 2 ELISA ELISA NNP cord-015021-pol2qm74 3057 3 's 's POS cord-015021-pol2qm74 3057 4 described describe VBN cord-015021-pol2qm74 3057 5 are be VBP cord-015021-pol2qm74 3057 6 useful useful JJ cord-015021-pol2qm74 3057 7 tools tool NNS cord-015021-pol2qm74 3057 8 to to TO cord-015021-pol2qm74 3057 9 do do VB cord-015021-pol2qm74 3057 10 these these DT cord-015021-pol2qm74 3057 11 investigations investigation NNS cord-015021-pol2qm74 3057 12 . . . cord-015021-pol2qm74 3058 1 Trauma trauma NN cord-015021-pol2qm74 3058 2 - - HYPH cord-015021-pol2qm74 3058 3 associated associate VBN cord-015021-pol2qm74 3058 4 immune immune JJ cord-015021-pol2qm74 3058 5 aberrations aberration NNS cord-015021-pol2qm74 3058 6 coincide coincide VBP cord-015021-pol2qm74 3058 7 with with IN cord-015021-pol2qm74 3058 8 augmented augment VBN cord-015021-pol2qm74 3058 9 release release NN cord-015021-pol2qm74 3058 10 of of IN cord-015021-pol2qm74 3058 11 immunoregulatory immunoregulatory JJ cord-015021-pol2qm74 3058 12 and and CC cord-015021-pol2qm74 3058 13 proinflammatory proinflammatory JJ cord-015021-pol2qm74 3058 14 cytokines cytokine NNS cord-015021-pol2qm74 3058 15 . . . cord-015021-pol2qm74 3059 1 The the DT cord-015021-pol2qm74 3059 2 present present JJ cord-015021-pol2qm74 3059 3 study study NN cord-015021-pol2qm74 3059 4 examines examine VBZ cord-015021-pol2qm74 3059 5 the the DT cord-015021-pol2qm74 3059 6 effect effect NN cord-015021-pol2qm74 3059 7 of of IN cord-015021-pol2qm74 3059 8 thermal thermal JJ cord-015021-pol2qm74 3059 9 trauma trauma NN cord-015021-pol2qm74 3059 10 on on IN cord-015021-pol2qm74 3059 11 the the DT cord-015021-pol2qm74 3059 12 capacity capacity NN cord-015021-pol2qm74 3059 13 for for IN cord-015021-pol2qm74 3059 14 specific specific JJ cord-015021-pol2qm74 3059 15 ( ( -LRB- cord-015021-pol2qm74 3059 16 receptormediated receptormediated JJ cord-015021-pol2qm74 3059 17 ) ) -RRB- cord-015021-pol2qm74 3059 18 response response NN cord-015021-pol2qm74 3059 19 of of IN cord-015021-pol2qm74 3059 20 lymphoid lymphoid JJ cord-015021-pol2qm74 3059 21 cells cell NNS cord-015021-pol2qm74 3059 22 to to IN cord-015021-pol2qm74 3059 23 interleukin interleukin NN cord-015021-pol2qm74 3059 24 1 1 CD cord-015021-pol2qm74 3059 25 ( ( -LRB- cord-015021-pol2qm74 3059 26 IL IL NNP cord-015021-pol2qm74 3059 27 1 1 CD cord-015021-pol2qm74 3059 28 ) ) -RRB- cord-015021-pol2qm74 3059 29 and and CC cord-015021-pol2qm74 3059 30 to to TO cord-015021-pol2qm74 3059 31 turnout turnout VB cord-015021-pol2qm74 3059 32 necrosis necrosis NN cord-015021-pol2qm74 3059 33 factor factor NN cord-015021-pol2qm74 3060 1 ~x ~x NNP cord-015021-pol2qm74 3061 1 ( ( -LRB- cord-015021-pol2qm74 3061 2 TNFc0 TNFc0 NNP cord-015021-pol2qm74 3061 3 . . . cord-015021-pol2qm74 3061 4 Methods method NNS cord-015021-pol2qm74 3061 5 . . . cord-015021-pol2qm74 3062 1 Bum bum NN cord-015021-pol2qm74 3062 2 patients patient NNS cord-015021-pol2qm74 3062 3 ( ( -LRB- cord-015021-pol2qm74 3062 4 N=24 N=24 NNP cord-015021-pol2qm74 3062 5 , , , cord-015021-pol2qm74 3062 6 25->75 25->75 CD cord-015021-pol2qm74 3062 7 % % NN cord-015021-pol2qm74 3062 8 total total JJ cord-015021-pol2qm74 3062 9 body body NN cord-015021-pol2qm74 3062 10 surface surface NN cord-015021-pol2qm74 3062 11 area area NN cord-015021-pol2qm74 3062 12 ) ) -RRB- cord-015021-pol2qm74 3062 13 were be VBD cord-015021-pol2qm74 3062 14 studied study VBN cord-015021-pol2qm74 3062 15 weekly weekly RB cord-015021-pol2qm74 3062 16 up up IN cord-015021-pol2qm74 3062 17 to to TO cord-015021-pol2qm74 3062 18 42 42 CD cord-015021-pol2qm74 3062 19 days day NNS cord-015021-pol2qm74 3062 20 post post NN cord-015021-pol2qm74 3062 21 - - JJ cord-015021-pol2qm74 3062 22 injury injury NN cord-015021-pol2qm74 3062 23 . . . cord-015021-pol2qm74 3063 1 The the DT cord-015021-pol2qm74 3063 2 Limulus Limulus NNP cord-015021-pol2qm74 3063 3 Amoebocyte Amoebocyte NNP cord-015021-pol2qm74 3063 4 Lysate Lysate NNP cord-015021-pol2qm74 3063 5 ( ( -LRB- cord-015021-pol2qm74 3063 6 LAL LAL NNP cord-015021-pol2qm74 3063 7 ) ) -RRB- cord-015021-pol2qm74 3063 8 test test NN cord-015021-pol2qm74 3063 9 was be VBD cord-015021-pol2qm74 3063 10 used use VBN cord-015021-pol2qm74 3063 11 to to TO cord-015021-pol2qm74 3063 12 measure measure VB cord-015021-pol2qm74 3063 13 plasma plasma NN cord-015021-pol2qm74 3063 14 endotoxin endotoxin NN cord-015021-pol2qm74 3063 15 levels level NNS cord-015021-pol2qm74 3063 16 . . . cord-015021-pol2qm74 3064 1 The the DT cord-015021-pol2qm74 3064 2 percentage percentage NN cord-015021-pol2qm74 3064 3 of of IN cord-015021-pol2qm74 3064 4 IL IL NNP cord-015021-pol2qm74 3064 5 1~-and 1~-and CD cord-015021-pol2qm74 3064 6 TNFcz TNFcz NNP cord-015021-pol2qm74 3064 7 - - HYPH cord-015021-pol2qm74 3064 8 binding bind VBG cord-015021-pol2qm74 3064 9 T(CD T(CD NNP cord-015021-pol2qm74 3064 10 5 5 CD cord-015021-pol2qm74 3064 11 ) ) -RRB- cord-015021-pol2qm74 3064 12 lymphocytes lymphocyte NNS cord-015021-pol2qm74 3064 13 was be VBD cord-015021-pol2qm74 3064 14 assessed assess VBN cord-015021-pol2qm74 3064 15 by by IN cord-015021-pol2qm74 3064 16 flow flow NN cord-015021-pol2qm74 3064 17 cytometry cytometry NN cord-015021-pol2qm74 3064 18 analysis analysis NN cord-015021-pol2qm74 3064 19 . . . cord-015021-pol2qm74 3065 1 Levels level NNS cord-015021-pol2qm74 3065 2 of of IN cord-015021-pol2qm74 3065 3 IL IL NNP cord-015021-pol2qm74 3065 4 1 1 CD cord-015021-pol2qm74 3065 5 receptor receptor NN cord-015021-pol2qm74 3065 6 antagonist antagonist NN cord-015021-pol2qm74 3065 7 ( ( -LRB- cord-015021-pol2qm74 3065 8 IL IL NNP cord-015021-pol2qm74 3065 9 lra lra NNP cord-015021-pol2qm74 3065 10 ) ) -RRB- cord-015021-pol2qm74 3065 11 in in IN cord-015021-pol2qm74 3065 12 patients patient NNS cord-015021-pol2qm74 3065 13 ' ' POS cord-015021-pol2qm74 3065 14 plasma plasma NN cord-015021-pol2qm74 3065 15 and and CC cord-015021-pol2qm74 3065 16 cultures culture NNS cord-015021-pol2qm74 3065 17 of of IN cord-015021-pol2qm74 3065 18 peripheral peripheral JJ cord-015021-pol2qm74 3065 19 blood blood NN cord-015021-pol2qm74 3065 20 ceils ceil NNS cord-015021-pol2qm74 3065 21 ( ( -LRB- cord-015021-pol2qm74 3065 22 PBC PBC NNP cord-015021-pol2qm74 3065 23 ) ) -RRB- cord-015021-pol2qm74 3065 24 were be VBD cord-015021-pol2qm74 3065 25 determined determine VBN cord-015021-pol2qm74 3065 26 by by IN cord-015021-pol2qm74 3065 27 immunoassay immunoassay NN cord-015021-pol2qm74 3065 28 . . . cord-015021-pol2qm74 3066 1 Results result NNS cord-015021-pol2qm74 3066 2 . . . cord-015021-pol2qm74 3067 1 Plasma plasma NN cord-015021-pol2qm74 3067 2 endotoxin endotoxin NN cord-015021-pol2qm74 3067 3 concentrations concentration NNS cord-015021-pol2qm74 3067 4 were be VBD cord-015021-pol2qm74 3067 5 significantly significantly RB cord-015021-pol2qm74 3067 6 ( ( -LRB- cord-015021-pol2qm74 3067 7 P<0.05 P<0.05 NNS cord-015021-pol2qm74 3067 8 ) ) -RRB- cord-015021-pol2qm74 3067 9 increased increase VBD cord-015021-pol2qm74 3067 10 up up RB cord-015021-pol2qm74 3067 11 to to TO cord-015021-pol2qm74 3067 12 3 3 CD cord-015021-pol2qm74 3067 13 weeks week NNS cord-015021-pol2qm74 3067 14 post post JJ cord-015021-pol2qm74 3067 15 - - JJ cord-015021-pol2qm74 3067 16 bum bum JJ cord-015021-pol2qm74 3067 17 ( ( -LRB- cord-015021-pol2qm74 3067 18 means mean VBZ cord-015021-pol2qm74 3067 19 3.5 3.5 CD cord-015021-pol2qm74 3067 20 + + SYM cord-015021-pol2qm74 3067 21 1 1 CD cord-015021-pol2qm74 3067 22 in in IN cord-015021-pol2qm74 3067 23 non non JJ cord-015021-pol2qm74 3067 24 - - JJ cord-015021-pol2qm74 3067 25 surviving surviving JJ cord-015021-pol2qm74 3067 26 and and CC cord-015021-pol2qm74 3067 27 2.6 2.6 CD cord-015021-pol2qm74 3067 28 + + SYM cord-015021-pol2qm74 3067 29 0.6 0.6 CD cord-015021-pol2qm74 3067 30 U u NN cord-015021-pol2qm74 3067 31 / / SYM cord-015021-pol2qm74 3067 32 ml ml XX cord-015021-pol2qm74 3067 33 in in IN cord-015021-pol2qm74 3067 34 surviving survive VBG cord-015021-pol2qm74 3067 35 patients patient NNS cord-015021-pol2qm74 3067 36 vs vs IN cord-015021-pol2qm74 3067 37 < < XX cord-015021-pol2qm74 3067 38 1U 1U NNP cord-015021-pol2qm74 3067 39 / / SYM cord-015021-pol2qm74 3067 40 ml ml XX cord-015021-pol2qm74 3067 41 in in IN cord-015021-pol2qm74 3067 42 the the DT cord-015021-pol2qm74 3067 43 control control NN cord-015021-pol2qm74 3067 44 ) ) -RRB- cord-015021-pol2qm74 3067 45 . . . cord-015021-pol2qm74 3068 1 Within within IN cord-015021-pol2qm74 3068 2 2 2 CD cord-015021-pol2qm74 3068 3 weeks week NNS cord-015021-pol2qm74 3068 4 of of IN cord-015021-pol2qm74 3068 5 bum bum NN cord-015021-pol2qm74 3068 6 , , , cord-015021-pol2qm74 3068 7 the the DT cord-015021-pol2qm74 3068 8 percentage percentage NN cord-015021-pol2qm74 3068 9 ofT oft VBP cord-015021-pol2qm74 3068 10 ceils ceil NNS cord-015021-pol2qm74 3068 11 expressing express VBG cord-015021-pol2qm74 3068 12 receptors receptor NNS cord-015021-pol2qm74 3068 13 for for IN cord-015021-pol2qm74 3068 14 TNFa TNFa NNS cord-015021-pol2qm74 3068 15 and and CC cord-015021-pol2qm74 3068 16 IL IL NNP cord-015021-pol2qm74 3068 17 1[~ 1[~ NNP cord-015021-pol2qm74 3068 18 constitutively constitutively RB cord-015021-pol2qm74 3068 19 was be VBD cord-015021-pol2qm74 3068 20 elevated elevate VBN cord-015021-pol2qm74 3068 21 ( ( -LRB- cord-015021-pol2qm74 3068 22 by by IN cord-015021-pol2qm74 3068 23 10 10 CD cord-015021-pol2qm74 3068 24 - - SYM cord-015021-pol2qm74 3068 25 15 15 CD cord-015021-pol2qm74 3068 26 fold fold NN cord-015021-pol2qm74 3068 27 ) ) -RRB- cord-015021-pol2qm74 3068 28 . . . cord-015021-pol2qm74 3069 1 In in IN cord-015021-pol2qm74 3069 2 contrast contrast NN cord-015021-pol2qm74 3069 3 , , , cord-015021-pol2qm74 3069 4 the the DT cord-015021-pol2qm74 3069 5 capacity capacity NN cord-015021-pol2qm74 3069 6 for for IN cord-015021-pol2qm74 3069 7 de de NNP cord-015021-pol2qm74 3069 8 novo novo NNP cord-015021-pol2qm74 3069 9 receptor receptor NN cord-015021-pol2qm74 3069 10 expression expression NN cord-015021-pol2qm74 3069 11 by by IN cord-015021-pol2qm74 3069 12 activated activate VBN cord-015021-pol2qm74 3069 13 PBC PBC NNP cord-015021-pol2qm74 3069 14 was be VBD cord-015021-pol2qm74 3069 15 reduced reduce VBN cord-015021-pol2qm74 3069 16 . . . cord-015021-pol2qm74 3070 1 Serum serum NN cord-015021-pol2qm74 3070 2 levels level NNS cord-015021-pol2qm74 3070 3 of of IN cord-015021-pol2qm74 3070 4 IL IL NNP cord-015021-pol2qm74 3070 5 Ira Ira NNP cord-015021-pol2qm74 3070 6 were be VBD cord-015021-pol2qm74 3070 7 significantly significantly RB cord-015021-pol2qm74 3070 8 increased increase VBN cord-015021-pol2qm74 3070 9 ( ( -LRB- cord-015021-pol2qm74 3070 10 range range VB cord-015021-pol2qm74 3070 11 2.5 2.5 CD cord-015021-pol2qm74 3070 12 - - HYPH cord-015021-pol2qm74 3070 13 40x10 40x10 CD cord-015021-pol2qm74 3070 14 J J NNP cord-015021-pol2qm74 3070 15 pg pg NNP cord-015021-pol2qm74 3070 16 / / SYM cord-015021-pol2qm74 3070 17 ml ml XX cord-015021-pol2qm74 3070 18 vs vs IN cord-015021-pol2qm74 3070 19 < < XX cord-015021-pol2qm74 3070 20 0.2x10 0.2x10 CD cord-015021-pol2qm74 3070 21 J J NNP cord-015021-pol2qm74 3070 22 pg pg NNP cord-015021-pol2qm74 3070 23 / / SYM cord-015021-pol2qm74 3070 24 ml ml XX cord-015021-pol2qm74 3070 25 in in IN cord-015021-pol2qm74 3070 26 the the DT cord-015021-pol2qm74 3070 27 control control NN cord-015021-pol2qm74 3070 28 ) ) -RRB- cord-015021-pol2qm74 3070 29 . . . cord-015021-pol2qm74 3071 1 In in IN cord-015021-pol2qm74 3071 2 all all DT cord-015021-pol2qm74 3071 3 patients patient NNS cord-015021-pol2qm74 3071 4 , , , cord-015021-pol2qm74 3071 5 high high JJ cord-015021-pol2qm74 3071 6 concentrations concentration NNS cord-015021-pol2qm74 3071 7 of of IN cord-015021-pol2qm74 3071 8 IL IL NNP cord-015021-pol2qm74 3071 9 lm lm NNP cord-015021-pol2qm74 3071 10 were be VBD cord-015021-pol2qm74 3071 11 released release VBN cord-015021-pol2qm74 3071 12 spontaneously spontaneously RB cord-015021-pol2qm74 3071 13 in in IN cord-015021-pol2qm74 3071 14 unstimulated unstimulated JJ cord-015021-pol2qm74 3071 15 cultures culture NNS cord-015021-pol2qm74 3071 16 of of IN cord-015021-pol2qm74 3071 17 adherent adherent JJ cord-015021-pol2qm74 3071 18 ceils ceil NNS cord-015021-pol2qm74 3071 19 ( ( -LRB- cord-015021-pol2qm74 3071 20 range range VBP cord-015021-pol2qm74 3071 21 20 20 CD cord-015021-pol2qm74 3071 22 - - SYM cord-015021-pol2qm74 3071 23 30x10 30x10 CD cord-015021-pol2qm74 3071 24 -3 -3 NNP cord-015021-pol2qm74 3071 25 pg pg NNP cord-015021-pol2qm74 3071 26 / / SYM cord-015021-pol2qm74 3071 27 ml ml NN cord-015021-pol2qm74 3071 28 vs vs IN cord-015021-pol2qm74 3071 29 4 4 CD cord-015021-pol2qm74 3071 30 - - SYM cord-015021-pol2qm74 3071 31 8x10J 8x10j CD cord-015021-pol2qm74 3071 32 pg pg NNP cord-015021-pol2qm74 3071 33 / / SYM cord-015021-pol2qm74 3071 34 ml ml XX cord-015021-pol2qm74 3071 35 in in IN cord-015021-pol2qm74 3071 36 the the DT cord-015021-pol2qm74 3071 37 control control NN cord-015021-pol2qm74 3071 38 ) ) -RRB- cord-015021-pol2qm74 3071 39 . . . cord-015021-pol2qm74 3072 1 However however RB cord-015021-pol2qm74 3072 2 , , , cord-015021-pol2qm74 3072 3 its -PRON- PRP$ cord-015021-pol2qm74 3072 4 secretion secretion NN cord-015021-pol2qm74 3072 5 was be VBD cord-015021-pol2qm74 3072 6 decreased decrease VBN cord-015021-pol2qm74 3072 7 in in IN cord-015021-pol2qm74 3072 8 LPS LPS NNP cord-015021-pol2qm74 3072 9 - - HYPH cord-015021-pol2qm74 3072 10 stimulated stimulate VBN cord-015021-pol2qm74 3072 11 parallel parallel JJ cord-015021-pol2qm74 3072 12 preparations preparation NNS cord-015021-pol2qm74 3072 13 . . . cord-015021-pol2qm74 3073 1 Conclusions conclusion NNS cord-015021-pol2qm74 3073 2 . . . cord-015021-pol2qm74 3074 1 In in IN cord-015021-pol2qm74 3074 2 the the DT cord-015021-pol2qm74 3074 3 bum bum NN cord-015021-pol2qm74 3074 4 patient patient NN cord-015021-pol2qm74 3074 5 , , , cord-015021-pol2qm74 3074 6 susceptibility susceptibility NN cord-015021-pol2qm74 3074 7 to to IN cord-015021-pol2qm74 3074 8 the the DT cord-015021-pol2qm74 3074 9 immunoregulatory immunoregulatory JJ cord-015021-pol2qm74 3074 10 effect effect NN cord-015021-pol2qm74 3074 11 of of IN cord-015021-pol2qm74 3074 12 TNFcz TNFcz NNP cord-015021-pol2qm74 3074 13 and and CC cord-015021-pol2qm74 3074 14 tL tL NNP cord-015021-pol2qm74 3074 15 1~ 1~ CD cord-015021-pol2qm74 3074 16 may may MD cord-015021-pol2qm74 3074 17 be be VB cord-015021-pol2qm74 3074 18 modulated modulate VBN cord-015021-pol2qm74 3074 19 by by IN cord-015021-pol2qm74 3074 20 infection infection NN cord-015021-pol2qm74 3074 21 - - HYPH cord-015021-pol2qm74 3074 22 related relate VBN cord-015021-pol2qm74 3074 23 products product NNS cord-015021-pol2qm74 3074 24 . . . cord-015021-pol2qm74 3075 1 Alterations alteration NNS cord-015021-pol2qm74 3075 2 in in IN cord-015021-pol2qm74 3075 3 the the DT cord-015021-pol2qm74 3075 4 capacity capacity NN cord-015021-pol2qm74 3075 5 for for IN cord-015021-pol2qm74 3075 6 receptor receptor NN cord-015021-pol2qm74 3075 7 expression expression NN cord-015021-pol2qm74 3075 8 and and CC cord-015021-pol2qm74 3075 9 secretion secretion NN cord-015021-pol2qm74 3075 10 of of IN cord-015021-pol2qm74 3075 11 1L 1l CD cord-015021-pol2qm74 3076 1 lra lra NNP cord-015021-pol2qm74 3076 2 may may MD cord-015021-pol2qm74 3076 3 affect affect VB cord-015021-pol2qm74 3076 4 IL IL NNP cord-015021-pol2qm74 3076 5 1-regulated 1-regulated CD cord-015021-pol2qm74 3076 6 biological biological JJ cord-015021-pol2qm74 3076 7 responses response NNS cord-015021-pol2qm74 3076 8 including include VBG cord-015021-pol2qm74 3076 9 specific specific JJ cord-015021-pol2qm74 3076 10 immune immune JJ cord-015021-pol2qm74 3076 11 reactions reaction NNS cord-015021-pol2qm74 3076 12 . . . cord-015021-pol2qm74 3077 1 While while IN cord-015021-pol2qm74 3077 2 studies study NNS cord-015021-pol2qm74 3077 3 suggest suggest VBP cord-015021-pol2qm74 3077 4 that that IN cord-015021-pol2qm74 3077 5 IL-10 IL-10 NNP cord-015021-pol2qm74 3077 6 is be VBZ cord-015021-pol2qm74 3077 7 an an DT cord-015021-pol2qm74 3077 8 important important JJ cord-015021-pol2qm74 3077 9 lymphokine lymphokine NN cord-015021-pol2qm74 3077 10 involved involve VBN cord-015021-pol2qm74 3077 11 in in IN cord-015021-pol2qm74 3077 12 cell cell NN cord-015021-pol2qm74 3077 13 - - HYPH cord-015021-pol2qm74 3077 14 mediated mediate VBN cord-015021-pol2qm74 3077 15 immunity immunity NN cord-015021-pol2qm74 3077 16 , , , cord-015021-pol2qm74 3077 17 little little JJ cord-015021-pol2qm74 3077 18 is be VBZ cord-015021-pol2qm74 3077 19 known know VBN cord-015021-pol2qm74 3077 20 about about IN cord-015021-pol2qm74 3077 21 this this DT cord-015021-pol2qm74 3077 22 mediator mediator NN cord-015021-pol2qm74 3077 23 's 's POS cord-015021-pol2qm74 3077 24 role role NN cord-015021-pol2qm74 3077 25 in in IN cord-015021-pol2qm74 3077 26 HEM HEM NNP cord-015021-pol2qm74 3077 27 - - HYPH cord-015021-pol2qm74 3077 28 induced induce VBN cord-015021-pol2qm74 3077 29 immunesuppression immunesuppression NN cord-015021-pol2qm74 3077 30 . . . cord-015021-pol2qm74 3078 1 Our -PRON- PRP$ cord-015021-pol2qm74 3078 2 aims aim NNS cord-015021-pol2qm74 3078 3 , , , cord-015021-pol2qm74 3078 4 therefore therefore RB cord-015021-pol2qm74 3078 5 , , , cord-015021-pol2qm74 3078 6 were be VBD cord-015021-pol2qm74 3078 7 to to TO cord-015021-pol2qm74 3078 8 determine determine VB cord-015021-pol2qm74 3078 9 : : : cord-015021-pol2qm74 3079 1 I -PRON- PRP cord-015021-pol2qm74 3079 2 ) ) -RRB- cord-015021-pol2qm74 3079 3 if if IN cord-015021-pol2qm74 3079 4 IL-10 IL-10 NNP cord-015021-pol2qm74 3079 5 contributes contribute VBZ cord-015021-pol2qm74 3079 6 to to IN cord-015021-pol2qm74 3079 7 depressed depressed JJ cord-015021-pol2qm74 3079 8 T t NN cord-015021-pol2qm74 3079 9 - - HYPH cord-015021-pol2qm74 3079 10 cell cell NN cord-015021-pol2qm74 3079 11 responses response NNS cord-015021-pol2qm74 3079 12 seen see VBN cord-015021-pol2qm74 3079 13 following follow VBG cord-015021-pol2qm74 3079 14 HEM HEM NNP cord-015021-pol2qm74 3079 15 ; ; : cord-015021-pol2qm74 3079 16 and and CC cord-015021-pol2qm74 3079 17 2 2 LS cord-015021-pol2qm74 3079 18 ) ) -RRB- cord-015021-pol2qm74 3080 1 how how WRB cord-015021-pol2qm74 3080 2 other other JJ cord-015021-pol2qm74 3080 3 agents agent NNS cord-015021-pol2qm74 3080 4 , , , cord-015021-pol2qm74 3080 5 known know VBN cord-015021-pol2qm74 3080 6 to to TO cord-015021-pol2qm74 3080 7 play play VB cord-015021-pol2qm74 3080 8 a a DT cord-015021-pol2qm74 3080 9 role role NN cord-015021-pol2qm74 3080 10 in in IN cord-015021-pol2qm74 3080 11 HEM HEM NNP cord-015021-pol2qm74 3080 12 , , , cord-015021-pol2qm74 3080 13 effect effect NN cord-015021-pol2qm74 3080 14 IL-10 IL-10 NNP cord-015021-pol2qm74 3080 15 release release NN cord-015021-pol2qm74 3080 16 . . . cord-015021-pol2qm74 3081 1 To to TO cord-015021-pol2qm74 3081 2 study study VB cord-015021-pol2qm74 3081 3 this this DT cord-015021-pol2qm74 3081 4 , , , cord-015021-pol2qm74 3081 5 C3H c3h JJ cord-015021-pol2qm74 3081 6 / / SYM cord-015021-pol2qm74 3081 7 HeN hen JJ cord-015021-pol2qm74 3081 8 mice mouse NNS cord-015021-pol2qm74 3081 9 were be VBD cord-015021-pol2qm74 3081 10 bled bleed VBN cord-015021-pol2qm74 3081 11 to to IN cord-015021-pol2qm74 3081 12 and and CC cord-015021-pol2qm74 3081 13 maintained maintain VBD cord-015021-pol2qm74 3081 14 at at IN cord-015021-pol2qm74 3081 15 a a DT cord-015021-pol2qm74 3081 16 MAP map NN cord-015021-pol2qm74 3081 17 of of IN cord-015021-pol2qm74 3081 18 35 35 CD cord-015021-pol2qm74 3081 19 mmHg mmHg NNS cord-015021-pol2qm74 3081 20 for for IN cord-015021-pol2qm74 3081 21 1 1 CD cord-015021-pol2qm74 3081 22 h h NN cord-015021-pol2qm74 3081 23 and and CC cord-015021-pol2qm74 3081 24 then then RB cord-015021-pol2qm74 3081 25 adequately adequately RB cord-015021-pol2qm74 3081 26 resuscitated resuscitate VBD cord-015021-pol2qm74 3081 27 . . . cord-015021-pol2qm74 3082 1 Mice mouse NNS cord-015021-pol2qm74 3082 2 were be VBD cord-015021-pol2qm74 3082 3 killed kill VBN cord-015021-pol2qm74 3082 4 2 2 CD cord-015021-pol2qm74 3082 5 h h NN cord-015021-pol2qm74 3082 6 post post NN cord-015021-pol2qm74 3082 7 - - JJ cord-015021-pol2qm74 3082 8 HEM HEM NNP cord-015021-pol2qm74 3082 9 to to TO cord-015021-pol2qm74 3082 10 obtain obtain VB cord-015021-pol2qm74 3082 11 splenic splenic JJ cord-015021-pol2qm74 3082 12 T t NN cord-015021-pol2qm74 3082 13 - - HYPH cord-015021-pol2qm74 3082 14 cells cell NNS cord-015021-pol2qm74 3082 15 ( ( -LRB- cord-015021-pol2qm74 3082 16 nylon nylon NN cord-015021-pol2qm74 3082 17 - - HYPH cord-015021-pol2qm74 3082 18 wool wool NN cord-015021-pol2qm74 3082 19 purified purify VBN cord-015021-pol2qm74 3082 20 ) ) -RRB- cord-015021-pol2qm74 3082 21 . . . cord-015021-pol2qm74 3083 1 IL-10 IL-10 NNP cord-015021-pol2qm74 3083 2 's 's POS cord-015021-pol2qm74 3083 3 immunosuppressant immunosuppressant JJ cord-015021-pol2qm74 3083 4 role role NN cord-015021-pol2qm74 3083 5 was be VBD cord-015021-pol2qm74 3083 6 demonstrated demonstrate VBN cord-015021-pol2qm74 3083 7 by by IN cord-015021-pol2qm74 3083 8 the the DT cord-015021-pol2qm74 3083 9 ability ability NN cord-015021-pol2qm74 3083 10 of of IN cord-015021-pol2qm74 3083 11 monoclenal monoclenal JJ cord-015021-pol2qm74 3083 12 antibody antibody NN cord-015021-pol2qm74 3083 13 ( ( -LRB- cord-015021-pol2qm74 3083 14 Mab Mab NNP cord-015021-pol2qm74 3083 15 ) ) -RRB- cord-015021-pol2qm74 3083 16 to to IN cord-015021-pol2qm74 3083 17 IL-10 IL-10 NNP cord-015021-pol2qm74 3083 18 to to TO cord-015021-pol2qm74 3083 19 markedly markedly RB cord-015021-pol2qm74 3083 20 improve improve VB cord-015021-pol2qm74 3083 21 the the DT cord-015021-pol2qm74 3083 22 T t NN cord-015021-pol2qm74 3083 23 - - HYPH cord-015021-pol2qm74 3083 24 cell cell NN cord-015021-pol2qm74 3083 25 proliferative proliferative JJ cord-015021-pol2qm74 3083 26 response response NN cord-015021-pol2qm74 3083 27 [ [ -LRB- cord-015021-pol2qm74 3083 28 2.5 2.5 CD cord-015021-pol2qm74 3083 29 # # NN cord-015021-pol2qm74 3083 30 g g NN cord-015021-pol2qm74 3084 1 The the DT cord-015021-pol2qm74 3084 2 marked marked JJ cord-015021-pol2qm74 3084 3 increase increase NN cord-015021-pol2qm74 3084 4 in in IN cord-015021-pol2qm74 3084 5 capacity capacity NN cord-015021-pol2qm74 3084 6 of of IN cord-015021-pol2qm74 3084 7 T t NN cord-015021-pol2qm74 3084 8 - - HYPH cord-015021-pol2qm74 3084 9 cells cell NNS cord-015021-pol2qm74 3084 10 from from IN cord-015021-pol2qm74 3084 11 HEM HEM NNP cord-015021-pol2qm74 3084 12 mice mouse NNS cord-015021-pol2qm74 3084 13 to to TO cord-015021-pol2qm74 3084 14 produce produce VB cord-015021-pol2qm74 3084 15 IL-10 IL-10 NNP cord-015021-pol2qm74 3084 16 was be VBD cord-015021-pol2qm74 3084 17 significantly significantly RB cord-015021-pol2qm74 3084 18 reduced reduce VBN cord-015021-pol2qm74 3084 19 by by IN cord-015021-pol2qm74 3084 20 treatment treatment NN cord-015021-pol2qm74 3084 21 with with IN cord-015021-pol2qm74 3084 22 either either CC cord-015021-pol2qm74 3084 23 IBU IBU NNP cord-015021-pol2qm74 3084 24 or or CC cord-015021-pol2qm74 3084 25 Mabs Mabs NNP cord-015021-pol2qm74 3084 26 . . . cord-015021-pol2qm74 3085 1 Since since IN cord-015021-pol2qm74 3085 2 IBU IBU NNP cord-015021-pol2qm74 3085 3 , , , cord-015021-pol2qm74 3085 4 TGF-~ TGF-~ NNP cord-015021-pol2qm74 3085 5 , , , cord-015021-pol2qm74 3085 6 as as RB cord-015021-pol2qm74 3085 7 well well RB cord-015021-pol2qm74 3085 8 as as IN cord-015021-pol2qm74 3085 9 IL-6 IL-6 NNP cord-015021-pol2qm74 3085 10 are be VBP cord-015021-pol2qm74 3085 11 all all DT cord-015021-pol2qm74 3085 12 reported report VBN cord-015021-pol2qm74 3085 13 to to IN cord-015021-pol2qm74 3085 14 directly directly RB cord-015021-pol2qm74 3085 15 / / SYM cord-015021-pol2qm74 3085 16 indirectly indirectly RB cord-015021-pol2qm74 3085 17 influence influence VBP cord-015021-pol2qm74 3085 18 prostanoid prostanoid NNP cord-015021-pol2qm74 3085 19 synthesis synthesis NN cord-015021-pol2qm74 3085 20 , , , cord-015021-pol2qm74 3085 21 this this DT cord-015021-pol2qm74 3085 22 implies imply VBZ cord-015021-pol2qm74 3085 23 that that IN cord-015021-pol2qm74 3085 24 eicosanoids eicosanoid NNS cord-015021-pol2qm74 3085 25 play play VBP cord-015021-pol2qm74 3085 26 a a DT cord-015021-pol2qm74 3085 27 major major JJ cord-015021-pol2qm74 3085 28 role role NN cord-015021-pol2qm74 3085 29 in in IN cord-015021-pol2qm74 3085 30 inducing induce VBG cord-015021-pol2qm74 3085 31 IL-10 IL-10 NNP cord-015021-pol2qm74 3085 32 release release NN cord-015021-pol2qm74 3085 33 by by IN cord-015021-pol2qm74 3085 34 T T NNP cord-015021-pol2qm74 3085 35 - - HYPH cord-015021-pol2qm74 3085 36 cells cell NNS cord-015021-pol2qm74 3085 37 following follow VBG cord-015021-pol2qm74 3085 38 HEM HEM NNP cord-015021-pol2qm74 3085 39 which which WDT cord-015021-pol2qm74 3085 40 depresses depress VBZ cord-015021-pol2qm74 3085 41 T t NN cord-015021-pol2qm74 3085 42 - - HYPH cord-015021-pol2qm74 3085 43 cell cell NN cord-015021-pol2qm74 3085 44 function function NN cord-015021-pol2qm74 3085 45 . . . cord-015021-pol2qm74 3086 1 The the DT cord-015021-pol2qm74 3086 2 mechanisms mechanism NNS cord-015021-pol2qm74 3086 3 underlying underlie VBG cord-015021-pol2qm74 3086 4 immunosuppression immunosuppression NN cord-015021-pol2qm74 3086 5 induced induce VBN cord-015021-pol2qm74 3086 6 by by IN cord-015021-pol2qm74 3086 7 thermal thermal JJ cord-015021-pol2qm74 3086 8 injury injury NN cord-015021-pol2qm74 3086 9 and and CC cord-015021-pol2qm74 3086 10 alcohol alcohol NN cord-015021-pol2qm74 3086 11 ingestion ingestion NN cord-015021-pol2qm74 3086 12 are be VBP cord-015021-pol2qm74 3086 13 in in IN cord-015021-pol2qm74 3086 14 part part NN cord-015021-pol2qm74 3086 15 due due IN cord-015021-pol2qm74 3086 16 to to IN cord-015021-pol2qm74 3086 17 cytokine cytokine JJ cord-015021-pol2qm74 3086 18 dysregulatinn dysregulatinn NN cord-015021-pol2qm74 3086 19 . . . cord-015021-pol2qm74 3087 1 IL-10 IL-10 NNP cord-015021-pol2qm74 3088 1 down down RB cord-015021-pol2qm74 3088 2 - - HYPH cord-015021-pol2qm74 3088 3 regulates regulate VBZ cord-015021-pol2qm74 3088 4 production production NN cord-015021-pol2qm74 3088 5 of of IN cord-015021-pol2qm74 3088 6 eytokines eytokines NNP cord-015021-pol2qm74 3088 7 by by IN cord-015021-pol2qm74 3088 8 maerophages maerophage NNS cord-015021-pol2qm74 3088 9 and and CC cord-015021-pol2qm74 3088 10 may may MD cord-015021-pol2qm74 3088 11 be be VB cord-015021-pol2qm74 3088 12 an an DT cord-015021-pol2qm74 3088 13 important important JJ cord-015021-pol2qm74 3088 14 regulator regulator NN cord-015021-pol2qm74 3088 15 of of IN cord-015021-pol2qm74 3088 16 the the DT cord-015021-pol2qm74 3088 17 initiation initiation NN cord-015021-pol2qm74 3088 18 of of IN cord-015021-pol2qm74 3088 19 the the DT cord-015021-pol2qm74 3088 20 immune immune JJ cord-015021-pol2qm74 3088 21 response response NN cord-015021-pol2qm74 3088 22 . . . cord-015021-pol2qm74 3089 1 IL-10 IL-10 NNP cord-015021-pol2qm74 3089 2 has have VBZ cord-015021-pol2qm74 3089 3 also also RB cord-015021-pol2qm74 3089 4 been be VBN cord-015021-pol2qm74 3089 5 demonstrated demonstrate VBN cord-015021-pol2qm74 3089 6 to to TO cord-015021-pol2qm74 3089 7 inhibit inhibit VB cord-015021-pol2qm74 3089 8 the the DT cord-015021-pol2qm74 3089 9 production production NN cord-015021-pol2qm74 3089 10 of of IN cord-015021-pol2qm74 3089 11 NO no NN cord-015021-pol2qm74 3089 12 by by IN cord-015021-pol2qm74 3089 13 macrophages macrophage NNS cord-015021-pol2qm74 3089 14 . . . cord-015021-pol2qm74 3090 1 This this DT cord-015021-pol2qm74 3090 2 study study NN cord-015021-pol2qm74 3090 3 examined examine VBD cord-015021-pol2qm74 3090 4 the the DT cord-015021-pol2qm74 3090 5 alterations alteration NNS cord-015021-pol2qm74 3090 6 in in IN cord-015021-pol2qm74 3090 7 eytokine eytokine JJ cord-015021-pol2qm74 3090 8 production production NN cord-015021-pol2qm74 3090 9 and and CC cord-015021-pol2qm74 3090 10 effect effect NN cord-015021-pol2qm74 3090 11 of of IN cord-015021-pol2qm74 3090 12 inhibition inhibition NN cord-015021-pol2qm74 3090 13 of of IN cord-015021-pol2qm74 3090 14 NO no DT cord-015021-pol2qm74 3090 15 production production NN cord-015021-pol2qm74 3090 16 on on IN cord-015021-pol2qm74 3090 17 immunologic immunologic JJ cord-015021-pol2qm74 3090 18 function function NN cord-015021-pol2qm74 3090 19 in in IN cord-015021-pol2qm74 3090 20 a a DT cord-015021-pol2qm74 3090 21 routine routine JJ cord-015021-pol2qm74 3090 22 thermal thermal JJ cord-015021-pol2qm74 3090 23 injury injury NN cord-015021-pol2qm74 3090 24 model model NN cord-015021-pol2qm74 3090 25 . . . cord-015021-pol2qm74 3091 1 METHODS methods NN cord-015021-pol2qm74 3091 2 : : : cord-015021-pol2qm74 3092 1 Balb Balb NNP cord-015021-pol2qm74 3092 2 / / SYM cord-015021-pol2qm74 3092 3 c c NN cord-015021-pol2qm74 3092 4 mice mouse NNS cord-015021-pol2qm74 3092 5 ( ( -LRB- cord-015021-pol2qm74 3092 6 n=40 n=40 NNP cord-015021-pol2qm74 3092 7 ) ) -RRB- cord-015021-pol2qm74 3092 8 were be VBD cord-015021-pol2qm74 3092 9 randomized randomize VBN cord-015021-pol2qm74 3092 10 to to IN cord-015021-pol2qm74 3092 11 4 4 CD cord-015021-pol2qm74 3092 12 groups group NNS cord-015021-pol2qm74 3092 13 : : : cord-015021-pol2qm74 3093 1 Saline Saline NNP cord-015021-pol2qm74 3093 2 - - HYPH cord-015021-pol2qm74 3093 3 Sham(NS Sham(NS NNP cord-015021-pol2qm74 3093 4 - - HYPH cord-015021-pol2qm74 3093 5 Sham Sham NNP cord-015021-pol2qm74 3093 6 ) ) -RRB- cord-015021-pol2qm74 3093 7 , , , cord-015021-pol2qm74 3093 8 Alcohol Alcohol NNP cord-015021-pol2qm74 3093 9 - - HYPH cord-015021-pol2qm74 3093 10 Sham(EtOH Sham(EtOH NNP cord-015021-pol2qm74 3093 11 - - HYPH cord-015021-pol2qm74 3093 12 Sham Sham NNP cord-015021-pol2qm74 3093 13 ) ) -RRB- cord-015021-pol2qm74 3093 14 , , , cord-015021-pol2qm74 3093 15 NS NS NNP cord-015021-pol2qm74 3093 16 - - HYPH cord-015021-pol2qm74 3093 17 Bum Bum NNP cord-015021-pol2qm74 3093 18 , , , cord-015021-pol2qm74 3093 19 EtOH EtOH NNP cord-015021-pol2qm74 3093 20 - - HYPH cord-015021-pol2qm74 3093 21 Bum Bum NNP cord-015021-pol2qm74 3093 22 . . . cord-015021-pol2qm74 3094 1 Animals animal NNS cord-015021-pol2qm74 3094 2 received receive VBD cord-015021-pol2qm74 3094 3 20 20 CD cord-015021-pol2qm74 3094 4 % % NN cord-015021-pol2qm74 3094 5 EtOH EtOH NNP cord-015021-pol2qm74 3094 6 or or CC cord-015021-pol2qm74 3094 7 NS NS NNP cord-015021-pol2qm74 3094 8 daily daily RB cord-015021-pol2qm74 3094 9 for for IN cord-015021-pol2qm74 3094 10 14 14 CD cord-015021-pol2qm74 3094 11 days day NNS cord-015021-pol2qm74 3094 12 by by IN cord-015021-pol2qm74 3094 13 gavage gavage NN cord-015021-pol2qm74 3094 14 . . . cord-015021-pol2qm74 3095 1 A a DT cord-015021-pol2qm74 3095 2 30 30 CD cord-015021-pol2qm74 3095 3 % % NN cord-015021-pol2qm74 3095 4 full full JJ cord-015021-pol2qm74 3095 5 thickness thickness NN cord-015021-pol2qm74 3095 6 bum bum NN cord-015021-pol2qm74 3095 7 was be VBD cord-015021-pol2qm74 3095 8 induced induce VBN cord-015021-pol2qm74 3095 9 4 4 CD cord-015021-pol2qm74 3095 10 hrs hrs NN cord-015021-pol2qm74 3095 11 after after IN cord-015021-pol2qm74 3095 12 the the DT cord-015021-pol2qm74 3095 13 last last JJ cord-015021-pol2qm74 3095 14 dose dose NN cord-015021-pol2qm74 3095 15 of of IN cord-015021-pol2qm74 3095 16 EtOH EtOH NNP cord-015021-pol2qm74 3095 17 or or CC cord-015021-pol2qm74 3095 18 NS NS NNP cord-015021-pol2qm74 3095 19 . . . cord-015021-pol2qm74 3096 1 Animals animal NNS cord-015021-pol2qm74 3096 2 were be VBD cord-015021-pol2qm74 3096 3 resuscitated resuscitate VBN cord-015021-pol2qm74 3096 4 , , , cord-015021-pol2qm74 3096 5 then then RB cord-015021-pol2qm74 3096 6 sacrificed sacrifice VBD cord-015021-pol2qm74 3096 7 4 4 CD cord-015021-pol2qm74 3096 8 days day NNS cord-015021-pol2qm74 3096 9 post post VBP cord-015021-pol2qm74 3096 10 bum bum NN cord-015021-pol2qm74 3096 11 . . . cord-015021-pol2qm74 3097 1 Splenic splenic JJ cord-015021-pol2qm74 3097 2 lymphocytes lymphocyte NNS cord-015021-pol2qm74 3097 3 were be VBD cord-015021-pol2qm74 3097 4 cultured culture VBN cord-015021-pol2qm74 3097 5 for for IN cord-015021-pol2qm74 3097 6 5 5 CD cord-015021-pol2qm74 3097 7 days day NNS cord-015021-pol2qm74 3097 8 with with IN cord-015021-pol2qm74 3097 9 LPS LPS NNP cord-015021-pol2qm74 3097 10 , , , cord-015021-pol2qm74 3097 11 and and CC cord-015021-pol2qm74 3097 12 LPS lp NNS cord-015021-pol2qm74 3097 13 with with IN cord-015021-pol2qm74 3097 14 two two CD cord-015021-pol2qm74 3097 15 concentrations concentration NNS cord-015021-pol2qm74 3097 16 of of IN cord-015021-pol2qm74 3097 17 N n CD cord-015021-pol2qm74 3097 18 - - HYPH cord-015021-pol2qm74 3097 19 Monomethyl Monomethyl NNP cord-015021-pol2qm74 3097 20 - - HYPH cord-015021-pol2qm74 3097 21 L L NNP cord-015021-pol2qm74 3097 22 - - HYPH cord-015021-pol2qm74 3097 23 Arginine Arginine NNP cord-015021-pol2qm74 3097 24 , , , cord-015021-pol2qm74 3097 25 a a DT cord-015021-pol2qm74 3097 26 nitric nitric NN cord-015021-pol2qm74 3097 27 oxide oxide NN cord-015021-pol2qm74 3097 28 inhibitor inhibitor NN cord-015021-pol2qm74 3097 29 ( ( -LRB- cord-015021-pol2qm74 3097 30 L L NNP cord-015021-pol2qm74 3097 31 - - HYPH cord-015021-pol2qm74 3097 32 NMMA NMMA NNP cord-015021-pol2qm74 3097 33 2.5ug 2.5ug CD cord-015021-pol2qm74 3097 34 / / SYM cord-015021-pol2qm74 3097 35 ml ml NN cord-015021-pol2qm74 3097 36 , , , cord-015021-pol2qm74 3097 37 10ug 10ug NN cord-015021-pol2qm74 3097 38 / / SYM cord-015021-pol2qm74 3097 39 ml ml NN cord-015021-pol2qm74 3097 40 ) ) -RRB- cord-015021-pol2qm74 3097 41 . . . cord-015021-pol2qm74 3098 1 Splenocyte splenocyte JJ cord-015021-pol2qm74 3098 2 production production NN cord-015021-pol2qm74 3098 3 of of IN cord-015021-pol2qm74 3098 4 IL-10 IL-10 NNP cord-015021-pol2qm74 3098 5 , , , cord-015021-pol2qm74 3098 6 Interferon interferon NN cord-015021-pol2qm74 3098 7 - - HYPH cord-015021-pol2qm74 3098 8 gamma gamma NN cord-015021-pol2qm74 3098 9 , , , cord-015021-pol2qm74 3099 1 IL-2 IL-2 NNP cord-015021-pol2qm74 3099 2 , , , cord-015021-pol2qm74 3099 3 PGE2 PGE2 NNP cord-015021-pol2qm74 3099 4 were be VBD cord-015021-pol2qm74 3099 5 measured measure VBN cord-015021-pol2qm74 3099 6 , , , cord-015021-pol2qm74 3099 7 and and CC cord-015021-pol2qm74 3099 8 lymphocyte lymphocyte NN cord-015021-pol2qm74 3099 9 proliferative proliferative JJ cord-015021-pol2qm74 3099 10 response response NN cord-015021-pol2qm74 3099 11 examined examine VBD cord-015021-pol2qm74 3099 12 . . . cord-015021-pol2qm74 3100 1 RESULTS result NNS cord-015021-pol2qm74 3100 2 : : : cord-015021-pol2qm74 3100 3 IL-10 IL-10 NNP cord-015021-pol2qm74 3101 1 production production NN cord-015021-pol2qm74 3101 2 was be VBD cord-015021-pol2qm74 3101 3 significantly significantly RB cord-015021-pol2qm74 3101 4 suppressed suppress VBN cord-015021-pol2qm74 3101 5 in in IN cord-015021-pol2qm74 3101 6 thermal thermal JJ cord-015021-pol2qm74 3101 7 injury injury NN cord-015021-pol2qm74 3101 8 . . . cord-015021-pol2qm74 3102 1 Exogenous exogenous JJ cord-015021-pol2qm74 3102 2 L L NNP cord-015021-pol2qm74 3102 3 - - HYPH cord-015021-pol2qm74 3102 4 NMMA NMMA NNP cord-015021-pol2qm74 3102 5 normalized normalize VBD cord-015021-pol2qm74 3102 6 the the DT cord-015021-pol2qm74 3102 7 suppression suppression NN cord-015021-pol2qm74 3102 8 of of IN cord-015021-pol2qm74 3102 9 11.-10 11.-10 CD cord-015021-pol2qm74 3102 10 in in IN cord-015021-pol2qm74 3102 11 a a DT cord-015021-pol2qm74 3102 12 dose dose NN cord-015021-pol2qm74 3102 13 - - HYPH cord-015021-pol2qm74 3102 14 dependent dependent JJ cord-015021-pol2qm74 3102 15 manner manner NN cord-015021-pol2qm74 3102 16 , , , cord-015021-pol2qm74 3102 17 indicating indicate VBG cord-015021-pol2qm74 3102 18 nitric nitric JJ cord-015021-pol2qm74 3102 19 oxide oxide NN cord-015021-pol2qm74 3102 20 may may MD cord-015021-pol2qm74 3102 21 modulate modulate VB cord-015021-pol2qm74 3102 22 IL-10 IL-10 NNP cord-015021-pol2qm74 3102 23 and and CC cord-015021-pol2qm74 3102 24 Interferon Interferon NNP cord-015021-pol2qm74 3102 25 - - HYPH cord-015021-pol2qm74 3102 26 gamma gamma NN cord-015021-pol2qm74 3102 27 production production NN cord-015021-pol2qm74 3102 28 in in IN cord-015021-pol2qm74 3102 29 thermal thermal JJ cord-015021-pol2qm74 3102 30 injury injury NN cord-015021-pol2qm74 3102 31 . . . cord-015021-pol2qm74 3103 1 IL-10 IL-10 NNP cord-015021-pol2qm74 3103 2 production production NN cord-015021-pol2qm74 3103 3 is be VBZ cord-015021-pol2qm74 3103 4 normal normal JJ cord-015021-pol2qm74 3103 5 in in IN cord-015021-pol2qm74 3103 6 EtOH etoh NN cord-015021-pol2qm74 3103 7 - - HYPH cord-015021-pol2qm74 3103 8 Burn burn NN cord-015021-pol2qm74 3103 9 animals animal NNS cord-015021-pol2qm74 3103 10 . . . cord-015021-pol2qm74 3104 1 CONCLUSION conclusion NN cord-015021-pol2qm74 3104 2 : : : cord-015021-pol2qm74 3104 3 IL-10 IL-10 NNP cord-015021-pol2qm74 3104 4 and and CC cord-015021-pol2qm74 3104 5 Interferon Interferon NNP cord-015021-pol2qm74 3104 6 - - HYPH cord-015021-pol2qm74 3104 7 gamma gamma NN cord-015021-pol2qm74 3104 8 production production NN cord-015021-pol2qm74 3104 9 is be VBZ cord-015021-pol2qm74 3104 10 altered alter VBN cord-015021-pol2qm74 3104 11 in in IN cord-015021-pol2qm74 3104 12 this this DT cord-015021-pol2qm74 3104 13 murine murine JJ cord-015021-pol2qm74 3104 14 thermal thermal JJ cord-015021-pol2qm74 3104 15 injury injury NN cord-015021-pol2qm74 3104 16 model model NN cord-015021-pol2qm74 3104 17 , , , cord-015021-pol2qm74 3104 18 and and CC cord-015021-pol2qm74 3104 19 may may MD cord-015021-pol2qm74 3104 20 contribute contribute VB cord-015021-pol2qm74 3104 21 to to IN cord-015021-pol2qm74 3104 22 this this DT cord-015021-pol2qm74 3104 23 injury injury NN cord-015021-pol2qm74 3104 24 - - HYPH cord-015021-pol2qm74 3104 25 induced induce VBN cord-015021-pol2qm74 3104 26 immunosuppression immunosuppression NN cord-015021-pol2qm74 3104 27 . . . cord-015021-pol2qm74 3105 1 Inhibition inhibition NN cord-015021-pol2qm74 3105 2 of of IN cord-015021-pol2qm74 3105 3 NO no DT cord-015021-pol2qm74 3105 4 synthesis synthesis NN cord-015021-pol2qm74 3105 5 normalizes normalize VBZ cord-015021-pol2qm74 3105 6 IL-10 IL-10 NNP cord-015021-pol2qm74 3105 7 production production NN cord-015021-pol2qm74 3105 8 and and CC cord-015021-pol2qm74 3105 9 should should MD cord-015021-pol2qm74 3105 10 be be VB cord-015021-pol2qm74 3105 11 investigated investigate VBN cord-015021-pol2qm74 3105 12 further further RB cord-015021-pol2qm74 3105 13 as as IN cord-015021-pol2qm74 3105 14 an an DT cord-015021-pol2qm74 3105 15 immanomodalator immanomodalator NN cord-015021-pol2qm74 3105 16 in in IN cord-015021-pol2qm74 3105 17 thermal thermal JJ cord-015021-pol2qm74 3105 18 injury injury NN cord-015021-pol2qm74 3105 19 . . . cord-015021-pol2qm74 3106 1 Surgery surgery NN cord-015021-pol2qm74 3106 2 , , , cord-015021-pol2qm74 3106 3 infection infection NN cord-015021-pol2qm74 3106 4 and and CC cord-015021-pol2qm74 3106 5 inflammation inflammation NN cord-015021-pol2qm74 3106 6 results result NNS cord-015021-pol2qm74 3106 7 in in IN cord-015021-pol2qm74 3106 8 the the DT cord-015021-pol2qm74 3106 9 production production NN cord-015021-pol2qm74 3106 10 of of IN cord-015021-pol2qm74 3106 11 pro pro JJ cord-015021-pol2qm74 3106 12 - - JJ cord-015021-pol2qm74 3106 13 inflammatory inflammatory JJ cord-015021-pol2qm74 3106 14 cytokines cytokine NNS cord-015021-pol2qm74 3106 15 which which WDT cord-015021-pol2qm74 3106 16 mediate mediate VBP cord-015021-pol2qm74 3106 17 metabolic metabolic JJ cord-015021-pol2qm74 3106 18 and and CC cord-015021-pol2qm74 3106 19 immunologic immunologic JJ cord-015021-pol2qm74 3106 20 host host NN cord-015021-pol2qm74 3106 21 responses response NNS cord-015021-pol2qm74 3106 22 . . . cord-015021-pol2qm74 3107 1 The the DT cord-015021-pol2qm74 3107 2 aim aim NN cord-015021-pol2qm74 3107 3 of of IN cord-015021-pol2qm74 3107 4 this this DT cord-015021-pol2qm74 3107 5 study study NN cord-015021-pol2qm74 3107 6 was be VBD cord-015021-pol2qm74 3107 7 to to TO cord-015021-pol2qm74 3107 8 characterise characterise VB cord-015021-pol2qm74 3107 9 the the DT cord-015021-pol2qm74 3107 10 elaboration elaboration NN cord-015021-pol2qm74 3107 11 of of IN cord-015021-pol2qm74 3107 12 cytokine cytokine NN cord-015021-pol2qm74 3107 13 release release NN cord-015021-pol2qm74 3107 14 following follow VBG cord-015021-pol2qm74 3107 15 a a DT cord-015021-pol2qm74 3107 16 variety variety NN cord-015021-pol2qm74 3107 17 of of IN cord-015021-pol2qm74 3107 18 surgical surgical JJ cord-015021-pol2qm74 3107 19 procedures procedure NNS cord-015021-pol2qm74 3107 20 . . . cord-015021-pol2qm74 3108 1 Twenty twenty CD cord-015021-pol2qm74 3108 2 one one CD cord-015021-pol2qm74 3108 3 patients patient NNS cord-015021-pol2qm74 3108 4 undergoing undergo VBG cord-015021-pol2qm74 3108 5 elective elective JJ cord-015021-pol2qm74 3108 6 intermediate intermediate JJ cord-015021-pol2qm74 3108 7 , , , cord-015021-pol2qm74 3108 8 hip hip NN cord-015021-pol2qm74 3108 9 , , , cord-015021-pol2qm74 3108 10 knee knee NN cord-015021-pol2qm74 3108 11 and and CC cord-015021-pol2qm74 3108 12 major major JJ cord-015021-pol2qm74 3108 13 gastrointestinal gastrointestinal JJ cord-015021-pol2qm74 3108 14 surgery surgery NN cord-015021-pol2qm74 3108 15 were be VBD cord-015021-pol2qm74 3108 16 studied study VBN cord-015021-pol2qm74 3108 17 . . . cord-015021-pol2qm74 3109 1 Levels level NNS cord-015021-pol2qm74 3109 2 of of IN cord-015021-pol2qm74 3109 3 interleukin-1 interleukin-1 NN cord-015021-pol2qm74 3109 4 ( ( -LRB- cord-015021-pol2qm74 3109 5 I1 i1 NN cord-015021-pol2qm74 3109 6 - - HYPH cord-015021-pol2qm74 3109 7 1 1 CD cord-015021-pol2qm74 3109 8 ) ) -RRB- cord-015021-pol2qm74 3109 9 , , , cord-015021-pol2qm74 3109 10 interleukin-6 interleukin-6 NNP cord-015021-pol2qm74 3109 11 ( ( -LRB- cord-015021-pol2qm74 3109 12 I1 I1 NNP cord-015021-pol2qm74 3109 13 - - HYPH cord-015021-pol2qm74 3109 14 6 6 CD cord-015021-pol2qm74 3109 15 ) ) -RRB- cord-015021-pol2qm74 3109 16 , , , cord-015021-pol2qm74 3109 17 the the DT cord-015021-pol2qm74 3109 18 interleukin-1 interleukin-1 NNP cord-015021-pol2qm74 3109 19 receptor receptor NN cord-015021-pol2qm74 3109 20 antagonist antagonist NN cord-015021-pol2qm74 3109 21 ( ( -LRB- cord-015021-pol2qm74 3109 22 I1 I1 NNP cord-015021-pol2qm74 3109 23 - - HYPH cord-015021-pol2qm74 3109 24 1RA 1RA NNP cord-015021-pol2qm74 3109 25 ) ) -RRB- cord-015021-pol2qm74 3109 26 and and CC cord-015021-pol2qm74 3109 27 the the DT cord-015021-pol2qm74 3109 28 acute acute JJ cord-015021-pol2qm74 3109 29 phase phase NN cord-015021-pol2qm74 3109 30 C c NN cord-015021-pol2qm74 3109 31 - - HYPH cord-015021-pol2qm74 3109 32 reactive reactive JJ cord-015021-pol2qm74 3109 33 protein protein NN cord-015021-pol2qm74 3109 34 ( ( -LRB- cord-015021-pol2qm74 3109 35 CRP CRP NNP cord-015021-pol2qm74 3109 36 ) ) -RRB- cord-015021-pol2qm74 3109 37 were be VBD cord-015021-pol2qm74 3109 38 measured measure VBN cord-015021-pol2qm74 3109 39 in in IN cord-015021-pol2qm74 3109 40 bloods blood NNS cord-015021-pol2qm74 3109 41 drawn draw VBN cord-015021-pol2qm74 3109 42 0 0 CD cord-015021-pol2qm74 3109 43 , , , cord-015021-pol2qm74 3109 44 1 1 CD cord-015021-pol2qm74 3109 45 , , , cord-015021-pol2qm74 3109 46 2 2 CD cord-015021-pol2qm74 3109 47 , , , cord-015021-pol2qm74 3109 48 4 4 CD cord-015021-pol2qm74 3109 49 , , , cord-015021-pol2qm74 3109 50 6 6 CD cord-015021-pol2qm74 3109 51 , , , cord-015021-pol2qm74 3109 52 12 12 CD cord-015021-pol2qm74 3109 53 , , , cord-015021-pol2qm74 3109 54 24 24 CD cord-015021-pol2qm74 3109 55 and and CC cord-015021-pol2qm74 3109 56 48 48 CD cord-015021-pol2qm74 3109 57 hours hour NNS cord-015021-pol2qm74 3109 58 following follow VBG cord-015021-pol2qm74 3109 59 operation operation NN cord-015021-pol2qm74 3109 60 . . . cord-015021-pol2qm74 3110 1 A a DT cord-015021-pol2qm74 3110 2 portion portion NN cord-015021-pol2qm74 3110 3 of of IN cord-015021-pol2qm74 3110 4 the the DT cord-015021-pol2qm74 3110 5 results result NNS cord-015021-pol2qm74 3110 6 are be VBP cord-015021-pol2qm74 3110 7 shown show VBN cord-015021-pol2qm74 3110 8 ( ( -LRB- cord-015021-pol2qm74 3110 9 mean mean VB cord-015021-pol2qm74 3110 10 -+ -+ NNP cord-015021-pol2qm74 3110 11 sem sem NNP cord-015021-pol2qm74 3110 12 ) ) -RRB- cord-015021-pol2qm74 3110 13 . . . cord-015021-pol2qm74 3111 1 135 135 CD cord-015021-pol2qm74 3111 2 + + SYM cord-015021-pol2qm74 3111 3 37 37 CD cord-015021-pol2qm74 3111 4 1738-+843 1738-+843 CD cord-015021-pol2qm74 3112 1 145_+24 145_+24 LS cord-015021-pol2qm74 3112 2 One one CD cord-015021-pol2qm74 3112 3 and and CC cord-015021-pol2qm74 3112 4 two two CD cord-015021-pol2qm74 3112 5 factor factor NN cord-015021-pol2qm74 3112 6 ANOVA ANOVA NNP cord-015021-pol2qm74 3112 7 ; ; : cord-015021-pol2qm74 3113 1 * * NFP cord-015021-pol2qm74 3113 2 p<0.0002 p<0.0002 NNP cord-015021-pol2qm74 3113 3 , , , cord-015021-pol2qm74 3113 4 # # NN cord-015021-pol2qm74 3113 5 p<0.0001 p<0.0001 XX cord-015021-pol2qm74 3113 6 , , , cord-015021-pol2qm74 3113 7 § § NN cord-015021-pol2qm74 3113 8 p<0.0009 p<0.0009 NNP cord-015021-pol2qm74 3113 9 , , , cord-015021-pol2qm74 3114 1 ¶p<0.0014 ¶p<0.0014 . cord-015021-pol2qm74 3115 1 , , , cord-015021-pol2qm74 3115 2 for for IN cord-015021-pol2qm74 3115 3 differences difference NNS cord-015021-pol2qm74 3115 4 between between IN cord-015021-pol2qm74 3115 5 groups group NNS cord-015021-pol2qm74 3115 6 I1 I1 NNP cord-015021-pol2qm74 3115 7 - - HYPH cord-015021-pol2qm74 3115 8 1 1 NNP cord-015021-pol2qm74 3115 9 was be VBD cord-015021-pol2qm74 3115 10 not not RB cord-015021-pol2qm74 3115 11 detected detect VBN cord-015021-pol2qm74 3115 12 at at IN cord-015021-pol2qm74 3115 13 any any DT cord-015021-pol2qm74 3115 14 time time NN cord-015021-pol2qm74 3115 15 point point NN cord-015021-pol2qm74 3115 16 . . . cord-015021-pol2qm74 3116 1 Both both DT cord-015021-pol2qm74 3116 2 II II NNP cord-015021-pol2qm74 3116 3 - - HYPH cord-015021-pol2qm74 3116 4 IRA IRA NNP cord-015021-pol2qm74 3116 5 and and CC cord-015021-pol2qm74 3116 6 I1 I1 NNP cord-015021-pol2qm74 3116 7 - - HYPH cord-015021-pol2qm74 3116 8 6 6 CD cord-015021-pol2qm74 3116 9 increased increase VBD cord-015021-pol2qm74 3116 10 after after IN cord-015021-pol2qm74 3116 11 surgery surgery NN cord-015021-pol2qm74 3116 12 . . . cord-015021-pol2qm74 3117 1 Maximum maximum JJ cord-015021-pol2qm74 3117 2 responses response NNS cord-015021-pol2qm74 3117 3 occurred occur VBD cord-015021-pol2qm74 3117 4 following follow VBG cord-015021-pol2qm74 3117 5 major major JJ cord-015021-pol2qm74 3117 6 GIT git NN cord-015021-pol2qm74 3117 7 and and CC cord-015021-pol2qm74 3117 8 hip hip NN cord-015021-pol2qm74 3117 9 surgery surgery NN cord-015021-pol2qm74 3117 10 , , , cord-015021-pol2qm74 3117 11 minimal minimal JJ cord-015021-pol2qm74 3117 12 responses response NNS cord-015021-pol2qm74 3117 13 were be VBD cord-015021-pol2qm74 3117 14 seen see VBN cord-015021-pol2qm74 3117 15 after after IN cord-015021-pol2qm74 3117 16 intermediate intermediate JJ cord-015021-pol2qm74 3117 17 and and CC cord-015021-pol2qm74 3117 18 knee knee NN cord-015021-pol2qm74 3117 19 surgery surgery NN cord-015021-pol2qm74 3117 20 . . . cord-015021-pol2qm74 3118 1 II II NNP cord-015021-pol2qm74 3118 2 - - HYPH cord-015021-pol2qm74 3118 3 IRA IRA NNP cord-015021-pol2qm74 3118 4 levels level NNS cord-015021-pol2qm74 3118 5 increased increase VBD cord-015021-pol2qm74 3118 6 within within IN cord-015021-pol2qm74 3118 7 two two CD cord-015021-pol2qm74 3118 8 hours hour NNS cord-015021-pol2qm74 3118 9 and and CC cord-015021-pol2qm74 3118 10 remained remain VBD cord-015021-pol2qm74 3118 11 elevated elevated JJ cord-015021-pol2qm74 3118 12 for for IN cord-015021-pol2qm74 3118 13 24 24 CD cord-015021-pol2qm74 3118 14 hours hour NNS cord-015021-pol2qm74 3118 15 ; ; : cord-015021-pol2qm74 3118 16 the the DT cord-015021-pol2qm74 3118 17 B B NNP cord-015021-pol2qm74 3118 18 - - HYPH cord-015021-pol2qm74 3118 19 IRA IRA NNP cord-015021-pol2qm74 3118 20 increase increase NN cord-015021-pol2qm74 3118 21 was be VBD cord-015021-pol2qm74 3118 22 a a DT cord-015021-pol2qm74 3118 23 thousand thousand CD cord-015021-pol2qm74 3118 24 fold fold VB cord-015021-pol2qm74 3118 25 greater great JJR cord-015021-pol2qm74 3118 26 than than IN cord-015021-pol2qm74 3118 27 the the DT cord-015021-pol2qm74 3118 28 rise rise NN cord-015021-pol2qm74 3118 29 in in IN cord-015021-pol2qm74 3118 30 I1 i1 NN cord-015021-pol2qm74 3118 31 - - HYPH cord-015021-pol2qm74 3118 32 6 6 CD cord-015021-pol2qm74 3118 33 levels level NNS cord-015021-pol2qm74 3118 34 . . . cord-015021-pol2qm74 3119 1 I1 i1 NN cord-015021-pol2qm74 3119 2 - - HYPH cord-015021-pol2qm74 3119 3 6 6 CD cord-015021-pol2qm74 3119 4 levels level NNS cord-015021-pol2qm74 3119 5 increased increase VBD cord-015021-pol2qm74 3119 6 up up RB cord-015021-pol2qm74 3119 7 to to TO cord-015021-pol2qm74 3119 8 24 24 CD cord-015021-pol2qm74 3119 9 hours hour NNS cord-015021-pol2qm74 3119 10 after after IN cord-015021-pol2qm74 3119 11 surgery surgery NN cord-015021-pol2qm74 3119 12 . . . cord-015021-pol2qm74 3120 1 CRP CRP NNP cord-015021-pol2qm74 3120 2 levels level NNS cord-015021-pol2qm74 3120 3 reflected reflect VBD cord-015021-pol2qm74 3120 4 maximum maximum JJ cord-015021-pol2qm74 3120 5 II II NNP cord-015021-pol2qm74 3120 6 - - HYPH cord-015021-pol2qm74 3120 7 IRA IRA NNP cord-015021-pol2qm74 3120 8 and and CC cord-015021-pol2qm74 3120 9 I1 I1 NNP cord-015021-pol2qm74 3120 10 - - HYPH cord-015021-pol2qm74 3120 11 6 6 CD cord-015021-pol2qm74 3120 12 levels level NNS cord-015021-pol2qm74 3120 13 ( ( -LRB- cord-015021-pol2qm74 3120 14 R2=.676 R2=.676 NNP cord-015021-pol2qm74 3120 15 , , , cord-015021-pol2qm74 3120 16 p<0.0001 p<0.0001 NNP cord-015021-pol2qm74 3120 17 and and CC cord-015021-pol2qm74 3120 18 R2=.282 R2=.282 NNS cord-015021-pol2qm74 3120 19 , , , cord-015021-pol2qm74 3120 20 p<0.04 p<0.04 NN cord-015021-pol2qm74 3120 21 respectively respectively RB cord-015021-pol2qm74 3120 22 ) ) -RRB- cord-015021-pol2qm74 3120 23 . . . cord-015021-pol2qm74 3121 1 High high JJ cord-015021-pol2qm74 3121 2 II-1RA II-1RA NNS cord-015021-pol2qm74 3121 3 and and CC cord-015021-pol2qm74 3121 4 I1 i1 NN cord-015021-pol2qm74 3121 5 - - HYPH cord-015021-pol2qm74 3121 6 6 6 CD cord-015021-pol2qm74 3121 7 levels level NNS cord-015021-pol2qm74 3121 8 reflect reflect VBP cord-015021-pol2qm74 3121 9 major major JJ cord-015021-pol2qm74 3121 10 surgery surgery NN cord-015021-pol2qm74 3121 11 , , , cord-015021-pol2qm74 3121 12 however however RB cord-015021-pol2qm74 3121 13 the the DT cord-015021-pol2qm74 3121 14 II II NNP cord-015021-pol2qm74 3121 15 - - HYPH cord-015021-pol2qm74 3121 16 IRA IRA NNP cord-015021-pol2qm74 3121 17 response response NN cord-015021-pol2qm74 3121 18 is be VBZ cord-015021-pol2qm74 3121 19 more more RBR cord-015021-pol2qm74 3121 20 rapid rapid JJ cord-015021-pol2qm74 3121 21 and and CC cord-015021-pol2qm74 3121 22 of of IN cord-015021-pol2qm74 3121 23 greater great JJR cord-015021-pol2qm74 3121 24 magnitude magnitude NN cord-015021-pol2qm74 3121 25 . . . cord-015021-pol2qm74 3122 1 The the DT cord-015021-pol2qm74 3122 2 strong strong JJ cord-015021-pol2qm74 3122 3 I1 i1 NN cord-015021-pol2qm74 3122 4 - - HYPH cord-015021-pol2qm74 3122 5 1RA 1ra CD cord-015021-pol2qm74 3122 6 correlation correlation NN cord-015021-pol2qm74 3122 7 with with IN cord-015021-pol2qm74 3122 8 CRP CRP NNP cord-015021-pol2qm74 3122 9 may may MD cord-015021-pol2qm74 3122 10 indicate indicate VB cord-015021-pol2qm74 3122 11 that that IN cord-015021-pol2qm74 3122 12 this this DT cord-015021-pol2qm74 3122 13 regulatory regulatory JJ cord-015021-pol2qm74 3122 14 cytokine cytokine NN cord-015021-pol2qm74 3122 15 is be VBZ cord-015021-pol2qm74 3122 16 itself -PRON- PRP cord-015021-pol2qm74 3122 17 a a DT cord-015021-pol2qm74 3122 18 mediator mediator NN cord-015021-pol2qm74 3122 19 of of IN cord-015021-pol2qm74 3122 20 host host NN cord-015021-pol2qm74 3122 21 responses response NNS cord-015021-pol2qm74 3122 22 to to IN cord-015021-pol2qm74 3122 23 surgery surgery NN cord-015021-pol2qm74 3122 24 . . . cord-015021-pol2qm74 3123 1 Dept Dept NNP cord-015021-pol2qm74 3123 2 . . NNP cord-015021-pol2qm74 3123 3 of of IN cord-015021-pol2qm74 3123 4 Surgery surgery NN cord-015021-pol2qm74 3123 5 , , , cord-015021-pol2qm74 3123 6 Meath Meath NNP cord-015021-pol2qm74 3123 7 / / SYM cord-015021-pol2qm74 3123 8 Adelaide Adelaide NNP cord-015021-pol2qm74 3123 9 Hospitals Hospitals NNPS cord-015021-pol2qm74 3123 10 , , , cord-015021-pol2qm74 3123 11 Heytesbury Heytesbury NNP cord-015021-pol2qm74 3123 12 St. St. NNP cord-015021-pol2qm74 3123 13 , , , cord-015021-pol2qm74 3123 14 Dublin Dublin NNP cord-015021-pol2qm74 3123 15 8 8 CD cord-015021-pol2qm74 3123 16 , , , cord-015021-pol2qm74 3123 17 Ireland Ireland NNP cord-015021-pol2qm74 3123 18 . . . cord-015021-pol2qm74 3124 1 CHANGE CHANGE NNP cord-015021-pol2qm74 3124 2 OF of IN cord-015021-pol2qm74 3124 3 IL-6 IL-6 NNP cord-015021-pol2qm74 3124 4 AND and CC cord-015021-pol2qm74 3124 5 SOLUBLE SOLUBLE NNP cord-015021-pol2qm74 3124 6 IL-6 IL-6 NNP cord-015021-pol2qm74 3124 7 RECEPTOR receptor NN cord-015021-pol2qm74 3124 8 LEVELS levels NN cord-015021-pol2qm74 3124 9 AFTER after IN cord-015021-pol2qm74 3124 10 SURGERY surgery NN cord-015021-pol2qm74 3124 11 S. S. NNP cord-015021-pol2qm74 3124 12 Hisano Hisano NNP cord-015021-pol2qm74 3124 13 , , , cord-015021-pol2qm74 3124 14 K. K. NNP cord-015021-pol2qm74 3124 15 Sakamoto Sakamoto NNP cord-015021-pol2qm74 3124 16 , , , cord-015021-pol2qm74 3124 17 S. S. NNP cord-015021-pol2qm74 3124 18 Mita Mita NNP cord-015021-pol2qm74 3124 19 , , , cord-015021-pol2qm74 3124 20 T. T. NNP cord-015021-pol2qm74 3124 21 Ishiko Ishiko NNP cord-015021-pol2qm74 3124 22 , , , cord-015021-pol2qm74 3124 23 M. M. NNP cord-015021-pol2qm74 3124 24 Ogawa Ogawa NNP cord-015021-pol2qm74 3124 25 [ [ -LRB- cord-015021-pol2qm74 3124 26 Objectives Objectives NNP cord-015021-pol2qm74 3124 27 ] ] -RRB- cord-015021-pol2qm74 3124 28 Under under IN cord-015021-pol2qm74 3124 29 surgical surgical JJ cord-015021-pol2qm74 3124 30 stress stress NN cord-015021-pol2qm74 3124 31 , , . cord-015021-pol2qm74 3125 1 IL-6 IL-6 NNP cord-015021-pol2qm74 3125 2 plays play VBZ cord-015021-pol2qm74 3125 3 a a DT cord-015021-pol2qm74 3125 4 main main JJ cord-015021-pol2qm74 3125 5 role role NN cord-015021-pol2qm74 3125 6 in in IN cord-015021-pol2qm74 3125 7 producing produce VBG cord-015021-pol2qm74 3125 8 acute acute JJ cord-015021-pol2qm74 3125 9 phase phase NN cord-015021-pol2qm74 3125 10 proteins protein NNS cord-015021-pol2qm74 3125 11 and and CC cord-015021-pol2qm74 3125 12 contributes contribute VBZ cord-015021-pol2qm74 3125 13 to to TO cord-015021-pol2qm74 3125 14 host host VB cord-015021-pol2qm74 3125 15 defense defense NN cord-015021-pol2qm74 3125 16 mechanism mechanism NN cord-015021-pol2qm74 3125 17 . . . cord-015021-pol2qm74 3126 1 Soluble soluble JJ cord-015021-pol2qm74 3126 2 IL-6 IL-6 NNP cord-015021-pol2qm74 3126 3 receptor receptor NN cord-015021-pol2qm74 3126 4 ( ( -LRB- cord-015021-pol2qm74 3126 5 slL-6R slL-6R NNS cord-015021-pol2qm74 3126 6 ) ) -RRB- cord-015021-pol2qm74 3126 7 is be VBZ cord-015021-pol2qm74 3126 8 considered consider VBN cord-015021-pol2qm74 3126 9 to to TO cord-015021-pol2qm74 3126 10 be be VB cord-015021-pol2qm74 3126 11 agonistic agonistic JJ cord-015021-pol2qm74 3126 12 to to IN cord-015021-pol2qm74 3126 13 IL-6 IL-6 NNP cord-015021-pol2qm74 3126 14 , , , cord-015021-pol2qm74 3126 15 unlike unlike IN cord-015021-pol2qm74 3126 16 other other JJ cord-015021-pol2qm74 3126 17 soluble soluble JJ cord-015021-pol2qm74 3126 18 type type NN cord-015021-pol2qm74 3126 19 receptors receptor NNS cord-015021-pol2qm74 3126 20 of of IN cord-015021-pol2qm74 3126 21 cytokines cytokine NNS cord-015021-pol2qm74 3126 22 . . . cord-015021-pol2qm74 3127 1 Here here RB cord-015021-pol2qm74 3127 2 we -PRON- PRP cord-015021-pol2qm74 3127 3 measured measure VBD cord-015021-pol2qm74 3127 4 IL-6 IL-6 NNP cord-015021-pol2qm74 3127 5 and and CC cord-015021-pol2qm74 3127 6 slL-6R slL-6R NNS cord-015021-pol2qm74 3127 7 levels level NNS cord-015021-pol2qm74 3127 8 in in IN cord-015021-pol2qm74 3127 9 the the DT cord-015021-pol2qm74 3127 10 serum serum NN cord-015021-pol2qm74 3127 11 and and CC cord-015021-pol2qm74 3127 12 drain drain VB cord-015021-pol2qm74 3127 13 fluid fluid NN cord-015021-pol2qm74 3127 14 from from IN cord-015021-pol2qm74 3127 15 surgical surgical JJ cord-015021-pol2qm74 3127 16 field field NN cord-015021-pol2qm74 3127 17 in in IN cord-015021-pol2qm74 3127 18 order order NN cord-015021-pol2qm74 3127 19 to to TO cord-015021-pol2qm74 3127 20 investigate investigate VB cord-015021-pol2qm74 3127 21 the the DT cord-015021-pol2qm74 3127 22 changes change NNS cord-015021-pol2qm74 3127 23 of of IN cord-015021-pol2qm74 3127 24 IL-6 IL-6 NNP cord-015021-pol2qm74 3127 25 and and CC cord-015021-pol2qm74 3127 26 slL-6R slL-6R NNS cord-015021-pol2qm74 3127 27 after after IN cord-015021-pol2qm74 3127 28 surgery surgery NN cord-015021-pol2qm74 3127 29 and and CC cord-015021-pol2qm74 3127 30 their -PRON- PRP$ cord-015021-pol2qm74 3127 31 origins origin NNS cord-015021-pol2qm74 3127 32 . . . cord-015021-pol2qm74 3128 1 [ [ -LRB- cord-015021-pol2qm74 3128 2 Materials material NNS cord-015021-pol2qm74 3128 3 and and CC cord-015021-pol2qm74 3128 4 Methods Methods NNPS cord-015021-pol2qm74 3128 5 ] ] -RRB- cord-015021-pol2qm74 3128 6 Serum serum NN cord-015021-pol2qm74 3128 7 and and CC cord-015021-pol2qm74 3128 8 drain drain VB cord-015021-pol2qm74 3128 9 fluid fluid NN cord-015021-pol2qm74 3128 10 samples sample NNS cord-015021-pol2qm74 3128 11 from from IN cord-015021-pol2qm74 3128 12 21 21 CD cord-015021-pol2qm74 3128 13 cases case NNS cord-015021-pol2qm74 3128 14 ( ( -LRB- cord-015021-pol2qm74 3128 15 6 6 CD cord-015021-pol2qm74 3128 16 of of IN cord-015021-pol2qm74 3128 17 esophagectomy esophagectomy NN cord-015021-pol2qm74 3128 18 and and CC cord-015021-pol2qm74 3128 19 15 15 CD cord-015021-pol2qm74 3128 20 of of IN cord-015021-pol2qm74 3128 21 gastrectomy gastrectomy NN cord-015021-pol2qm74 3128 22 ) ) -RRB- cord-015021-pol2qm74 3128 23 were be VBD cord-015021-pol2qm74 3128 24 serially serially RB cord-015021-pol2qm74 3128 25 collected collect VBN cord-015021-pol2qm74 3128 26 before before RB cord-015021-pol2qm74 3128 27 and and CC cord-015021-pol2qm74 3128 28 after after IN cord-015021-pol2qm74 3128 29 surgery surgery NN cord-015021-pol2qm74 3128 30 . . . cord-015021-pol2qm74 3129 1 IL-6 IL-6 NNP cord-015021-pol2qm74 3129 2 and and CC cord-015021-pol2qm74 3129 3 slL-6R slL-6R NNS cord-015021-pol2qm74 3129 4 levels level NNS cord-015021-pol2qm74 3129 5 were be VBD cord-015021-pol2qm74 3129 6 measured measure VBN cord-015021-pol2qm74 3129 7 by by IN cord-015021-pol2qm74 3129 8 ELISA ELISA NNP cord-015021-pol2qm74 3129 9 . . . cord-015021-pol2qm74 3130 1 [ [ -LRB- cord-015021-pol2qm74 3130 2 Results result NNS cord-015021-pol2qm74 3130 3 ] ] -RRB- cord-015021-pol2qm74 3130 4 ( ( -LRB- cord-015021-pol2qm74 3130 5 1 1 LS cord-015021-pol2qm74 3130 6 ) ) -RRB- cord-015021-pol2qm74 3130 7 Serum serum NN cord-015021-pol2qm74 3131 1 IL-6 IL-6 NNP cord-015021-pol2qm74 3131 2 : : : cord-015021-pol2qm74 3131 3 All all DT cord-015021-pol2qm74 3131 4 cases case NNS cord-015021-pol2qm74 3131 5 reached reach VBD cord-015021-pol2qm74 3131 6 the the DT cord-015021-pol2qm74 3131 7 maximum maximum JJ cord-015021-pol2qm74 3131 8 level level NN cord-015021-pol2qm74 3131 9 on on IN cord-015021-pol2qm74 3131 10 POD POD NNP cord-015021-pol2qm74 3131 11 - - HYPH cord-015021-pol2qm74 3131 12 l l NNP cord-015021-pol2qm74 3131 13 , , , cord-015021-pol2qm74 3131 14 more more RBR cord-015021-pol2qm74 3131 15 precisely precisely RB cord-015021-pol2qm74 3131 16 3 3 CD cord-015021-pol2qm74 3131 17 - - SYM cord-015021-pol2qm74 3131 18 6 6 CD cord-015021-pol2qm74 3131 19 hours hour NNS cord-015021-pol2qm74 3131 20 after after IN cord-015021-pol2qm74 3131 21 operation operation NN cord-015021-pol2qm74 3131 22 . . . cord-015021-pol2qm74 3132 1 ( ( -LRB- cord-015021-pol2qm74 3132 2 2 2 LS cord-015021-pol2qm74 3132 3 ) ) -RRB- cord-015021-pol2qm74 3132 4 IL-6 IL-6 NNP cord-015021-pol2qm74 3132 5 in in IN cord-015021-pol2qm74 3132 6 the the DT cord-015021-pol2qm74 3132 7 drain drain NN cord-015021-pol2qm74 3132 8 : : : cord-015021-pol2qm74 3132 9 Maximal maximal JJ cord-015021-pol2qm74 3132 10 IL-6 IL-6 NNP cord-015021-pol2qm74 3132 11 levels level NNS cord-015021-pol2qm74 3132 12 in in IN cord-015021-pol2qm74 3132 13 the the DT cord-015021-pol2qm74 3132 14 drain drain NN cord-015021-pol2qm74 3132 15 were be VBD cord-015021-pol2qm74 3132 16 recognized recognize VBN cord-015021-pol2qm74 3132 17 3 3 CD cord-015021-pol2qm74 3132 18 - - SYM cord-015021-pol2qm74 3132 19 6 6 CD cord-015021-pol2qm74 3132 20 hours hour NNS cord-015021-pol2qm74 3132 21 after after IN cord-015021-pol2qm74 3132 22 operation operation NN cord-015021-pol2qm74 3132 23 , , , cord-015021-pol2qm74 3132 24 at at IN cord-015021-pol2qm74 3132 25 almost almost RB cord-015021-pol2qm74 3132 26 the the DT cord-015021-pol2qm74 3132 27 same same JJ cord-015021-pol2qm74 3132 28 time time NN cord-015021-pol2qm74 3132 29 as as IN cord-015021-pol2qm74 3132 30 serum serum NN cord-015021-pol2qm74 3132 31 IL-6 IL-6 NNP cord-015021-pol2qm74 3132 32 . . . cord-015021-pol2qm74 3133 1 Furthermore furthermore RB cord-015021-pol2qm74 3133 2 the the DT cord-015021-pol2qm74 3133 3 IL-6 IL-6 NNP cord-015021-pol2qm74 3133 4 values value NNS cord-015021-pol2qm74 3133 5 in in IN cord-015021-pol2qm74 3133 6 the the DT cord-015021-pol2qm74 3133 7 drain drain NN cord-015021-pol2qm74 3133 8 were be VBD cord-015021-pol2qm74 3133 9 much much RB cord-015021-pol2qm74 3133 10 higher high JJR cord-015021-pol2qm74 3133 11 , , , cord-015021-pol2qm74 3133 12 about about RB cord-015021-pol2qm74 3133 13 100 100 CD cord-015021-pol2qm74 3133 14 times time NNS cord-015021-pol2qm74 3133 15 , , , cord-015021-pol2qm74 3133 16 than than IN cord-015021-pol2qm74 3133 17 those those DT cord-015021-pol2qm74 3133 18 in in IN cord-015021-pol2qm74 3133 19 serum serum NN cord-015021-pol2qm74 3133 20 . . . cord-015021-pol2qm74 3134 1 ( ( -LRB- cord-015021-pol2qm74 3134 2 3 3 LS cord-015021-pol2qm74 3134 3 ) ) -RRB- cord-015021-pol2qm74 3134 4 slL-6R slL-6R NNS cord-015021-pol2qm74 3134 5 in in IN cord-015021-pol2qm74 3134 6 the the DT cord-015021-pol2qm74 3134 7 serum serum NN cord-015021-pol2qm74 3134 8 : : : cord-015021-pol2qm74 3135 1 All all DT cord-015021-pol2qm74 3135 2 cases case NNS cord-015021-pol2qm74 3135 3 reached reach VBD cord-015021-pol2qm74 3135 4 minimum minimum JJ cord-015021-pol2qm74 3135 5 levels level NNS cord-015021-pol2qm74 3135 6 3 3 CD cord-015021-pol2qm74 3135 7 - - SYM cord-015021-pol2qm74 3135 8 12 12 CD cord-015021-pol2qm74 3135 9 hours hour NNS cord-015021-pol2qm74 3135 10 after after IN cord-015021-pol2qm74 3135 11 operation operation NN cord-015021-pol2qm74 3135 12 and and CC cord-015021-pol2qm74 3135 13 recovered recover VBD cord-015021-pol2qm74 3135 14 to to IN cord-015021-pol2qm74 3135 15 the the DT cord-015021-pol2qm74 3135 16 preoperative preoperative JJ cord-015021-pol2qm74 3135 17 levels level NNS cord-015021-pol2qm74 3135 18 a a DT cord-015021-pol2qm74 3135 19 few few JJ cord-015021-pol2qm74 3135 20 days day NNS cord-015021-pol2qm74 3135 21 later later RB cord-015021-pol2qm74 3135 22 ( ( -LRB- cord-015021-pol2qm74 3135 23 decrease decrease NN cord-015021-pol2qm74 3135 24 ratio ratio NN cord-015021-pol2qm74 3135 25 : : : cord-015021-pol2qm74 3135 26 43.9 43.9 CD cord-015021-pol2qm74 3135 27 + + SYM cord-015021-pol2qm74 3135 28 5.6~ 5.6~ CD cord-015021-pol2qm74 3135 29 , , , cord-015021-pol2qm74 3135 30 , , , cord-015021-pol2qm74 3135 31 range range NN cord-015021-pol2qm74 3135 32 : : : cord-015021-pol2qm74 3135 33 9 9 CD cord-015021-pol2qm74 3135 34 - - SYM cord-015021-pol2qm74 3135 35 84~ 84~ CD cord-015021-pol2qm74 3135 36 ' ' '' cord-015021-pol2qm74 3135 37 ) ) -RRB- cord-015021-pol2qm74 3135 38 . . . cord-015021-pol2qm74 3136 1 ( ( -LRB- cord-015021-pol2qm74 3136 2 4 4 LS cord-015021-pol2qm74 3136 3 ) ) -RRB- cord-015021-pol2qm74 3136 4 slL-6R slL-6R NNS cord-015021-pol2qm74 3136 5 in in IN cord-015021-pol2qm74 3136 6 the the DT cord-015021-pol2qm74 3136 7 drain drain NN cord-015021-pol2qm74 3136 8 : : : cord-015021-pol2qm74 3136 9 slL-6R slL-6R NNS cord-015021-pol2qm74 3136 10 levels level NNS cord-015021-pol2qm74 3136 11 in in IN cord-015021-pol2qm74 3136 12 the the DT cord-015021-pol2qm74 3136 13 drain drain NN cord-015021-pol2qm74 3136 14 showed show VBD cord-015021-pol2qm74 3136 15 almost almost RB cord-015021-pol2qm74 3136 16 the the DT cord-015021-pol2qm74 3136 17 same same JJ cord-015021-pol2qm74 3136 18 value value NN cord-015021-pol2qm74 3136 19 and and CC cord-015021-pol2qm74 3136 20 change change NN cord-015021-pol2qm74 3136 21 as as IN cord-015021-pol2qm74 3136 22 serum serum NN cord-015021-pol2qm74 3136 23 slL-6R. sll-6r. ADD cord-015021-pol2qm74 3136 24 [ [ -LRB- cord-015021-pol2qm74 3136 25 Conclusions conclusion NNS cord-015021-pol2qm74 3136 26 ] ] -RRB- cord-015021-pol2qm74 3136 27 ( ( -LRB- cord-015021-pol2qm74 3136 28 1 1 LS cord-015021-pol2qm74 3136 29 ) ) -RRB- cord-015021-pol2qm74 3136 30 IL-6 IL-6 NNP cord-015021-pol2qm74 3136 31 is be VBZ cord-015021-pol2qm74 3136 32 produced produce VBN cord-015021-pol2qm74 3136 33 from from IN cord-015021-pol2qm74 3136 34 the the DT cord-015021-pol2qm74 3136 35 cells cell NNS cord-015021-pol2qm74 3136 36 gathering gather VBG cord-015021-pol2qm74 3136 37 around around IN cord-015021-pol2qm74 3136 38 operative operative JJ cord-015021-pol2qm74 3136 39 fields field NNS cord-015021-pol2qm74 3136 40 whereas whereas IN cord-015021-pol2qm74 3136 41 slL-6R slL-6R NNP cord-015021-pol2qm74 3136 42 is be VBZ cord-015021-pol2qm74 3136 43 considered consider VBN cord-015021-pol2qm74 3136 44 to to TO cord-015021-pol2qm74 3136 45 be be VB cord-015021-pol2qm74 3136 46 produced produce VBN cord-015021-pol2qm74 3136 47 in in IN cord-015021-pol2qm74 3136 48 the the DT cord-015021-pol2qm74 3136 49 cells cell NNS cord-015021-pol2qm74 3136 50 which which WDT cord-015021-pol2qm74 3136 51 do do VBP cord-015021-pol2qm74 3136 52 not not RB cord-015021-pol2qm74 3136 53 gather gather VB cord-015021-pol2qm74 3136 54 around around IN cord-015021-pol2qm74 3136 55 the the DT cord-015021-pol2qm74 3136 56 operative operative JJ cord-015021-pol2qm74 3136 57 fields field NNS cord-015021-pol2qm74 3136 58 . . . cord-015021-pol2qm74 3137 1 ( ( -LRB- cord-015021-pol2qm74 3137 2 2 2 LS cord-015021-pol2qm74 3137 3 ) ) -RRB- cord-015021-pol2qm74 3138 1 There there EX cord-015021-pol2qm74 3138 2 may may MD cord-015021-pol2qm74 3138 3 be be VB cord-015021-pol2qm74 3138 4 a a DT cord-015021-pol2qm74 3138 5 mechanism mechanism NN cord-015021-pol2qm74 3138 6 that that WDT cord-015021-pol2qm74 3138 7 down down RB cord-015021-pol2qm74 3138 8 - - HYPH cord-015021-pol2qm74 3138 9 regulates regulate VBZ cord-015021-pol2qm74 3138 10 slL-6R slL-6R NNS cord-015021-pol2qm74 3138 11 in in IN cord-015021-pol2qm74 3138 12 the the DT cord-015021-pol2qm74 3138 13 early early JJ cord-015021-pol2qm74 3138 14 stage stage NN cord-015021-pol2qm74 3138 15 of of IN cord-015021-pol2qm74 3138 16 surgery surgery NN cord-015021-pol2qm74 3138 17 . . . cord-015021-pol2qm74 3139 1 [ [ -LRB- cord-015021-pol2qm74 3139 2 Objectives Objectives NNP cord-015021-pol2qm74 3139 3 ] ] -RRB- cord-015021-pol2qm74 3139 4 IL-6 IL-6 NNP cord-015021-pol2qm74 3139 5 plays play VBZ cord-015021-pol2qm74 3139 6 an an DT cord-015021-pol2qm74 3139 7 important important JJ cord-015021-pol2qm74 3139 8 role role NN cord-015021-pol2qm74 3139 9 in in IN cord-015021-pol2qm74 3139 10 host host NN cord-015021-pol2qm74 3139 11 defense defense NN cord-015021-pol2qm74 3139 12 in in IN cord-015021-pol2qm74 3139 13 the the DT cord-015021-pol2qm74 3139 14 early early JJ cord-015021-pol2qm74 3139 15 stage stage NN cord-015021-pol2qm74 3139 16 after after IN cord-015021-pol2qm74 3139 17 surgery surgery NN cord-015021-pol2qm74 3139 18 . . . cord-015021-pol2qm74 3140 1 In in IN cord-015021-pol2qm74 3140 2 the the DT cord-015021-pol2qm74 3140 3 present present JJ cord-015021-pol2qm74 3140 4 study study NN cord-015021-pol2qm74 3140 5 , , , cord-015021-pol2qm74 3140 6 we -PRON- PRP cord-015021-pol2qm74 3140 7 examined examine VBD cord-015021-pol2qm74 3140 8 changes change NNS cord-015021-pol2qm74 3140 9 in in IN cord-015021-pol2qm74 3140 10 IL-6 IL-6 NNP cord-015021-pol2qm74 3140 11 concentration concentration NN cord-015021-pol2qm74 3140 12 after after IN cord-015021-pol2qm74 3140 13 major major JJ cord-015021-pol2qm74 3140 14 thoracoabdominal thoracoabdominal JJ cord-015021-pol2qm74 3140 15 surgery surgery NN cord-015021-pol2qm74 3140 16 and and CC cord-015021-pol2qm74 3140 17 elucidated elucidate VBD cord-015021-pol2qm74 3140 18 the the DT cord-015021-pol2qm74 3140 19 effect effect NN cord-015021-pol2qm74 3140 20 of of IN cord-015021-pol2qm74 3140 21 surgical surgical JJ cord-015021-pol2qm74 3140 22 trauma trauma NN cord-015021-pol2qm74 3140 23 and and CC cord-015021-pol2qm74 3140 24 factors factor NNS cord-015021-pol2qm74 3140 25 influencing influence VBG cord-015021-pol2qm74 3140 26 postoperative postoperative JJ cord-015021-pol2qm74 3140 27 elevation elevation NN cord-015021-pol2qm74 3140 28 of of IN cord-015021-pol2qm74 3140 29 serum serum NN cord-015021-pol2qm74 3140 30 IL-6 IL-6 NNP cord-015021-pol2qm74 3140 31 . . . cord-015021-pol2qm74 3141 1 [ [ -LRB- cord-015021-pol2qm74 3141 2 Materials material NNS cord-015021-pol2qm74 3141 3 and and CC cord-015021-pol2qm74 3141 4 Methods Methods NNPS cord-015021-pol2qm74 3141 5 ] ] -RRB- cord-015021-pol2qm74 3141 6 Thirty thirty CD cord-015021-pol2qm74 3141 7 - - HYPH cord-015021-pol2qm74 3141 8 eight eight CD cord-015021-pol2qm74 3141 9 patients patient NNS cord-015021-pol2qm74 3141 10 undergoing undergo VBG cord-015021-pol2qm74 3141 11 elective elective JJ cord-015021-pol2qm74 3141 12 surgery surgery NN cord-015021-pol2qm74 3141 13 of of IN cord-015021-pol2qm74 3141 14 the the DT cord-015021-pol2qm74 3141 15 thoracoabdomen thoracoabdoman NNS cord-015021-pol2qm74 3141 16 were be VBD cord-015021-pol2qm74 3141 17 classified classify VBN cord-015021-pol2qm74 3141 18 into into IN cord-015021-pol2qm74 3141 19 6 6 CD cord-015021-pol2qm74 3141 20 groups group NNS cord-015021-pol2qm74 3141 21 according accord VBG cord-015021-pol2qm74 3141 22 to to IN cord-015021-pol2qm74 3141 23 the the DT cord-015021-pol2qm74 3141 24 location location NN cord-015021-pol2qm74 3141 25 of of IN cord-015021-pol2qm74 3141 26 the the DT cord-015021-pol2qm74 3141 27 operation operation NN cord-015021-pol2qm74 3141 28 . . . cord-015021-pol2qm74 3142 1 Bloods blood NNS cord-015021-pol2qm74 3142 2 and and CC cord-015021-pol2qm74 3142 3 drain drain NN cord-015021-pol2qm74 3142 4 fluids fluid NNS cord-015021-pol2qm74 3142 5 were be VBD cord-015021-pol2qm74 3142 6 serially serially RB cord-015021-pol2qm74 3142 7 obtained obtain VBN cord-015021-pol2qm74 3142 8 and and CC cord-015021-pol2qm74 3142 9 samples sample NNS cord-015021-pol2qm74 3142 10 were be VBD cord-015021-pol2qm74 3142 11 frozen freeze VBN cord-015021-pol2qm74 3142 12 until until IN cord-015021-pol2qm74 3142 13 measured measure VBN cord-015021-pol2qm74 3142 14 , , , cord-015021-pol2qm74 3142 15 keukocytes keukocytes NNP cord-015021-pol2qm74 3142 16 were be VBD cord-015021-pol2qm74 3142 17 simultaneously simultaneously RB cord-015021-pol2qm74 3142 18 collected collect VBN cord-015021-pol2qm74 3142 19 for for IN cord-015021-pol2qm74 3142 20 Northern northern JJ cord-015021-pol2qm74 3142 21 blot blot NN cord-015021-pol2qm74 3142 22 analysis analysis NN cord-015021-pol2qm74 3142 23 . . . cord-015021-pol2qm74 3143 1 Concentration concentration NN cord-015021-pol2qm74 3143 2 of of IN cord-015021-pol2qm74 3143 3 IL-6 IL-6 NNP cord-015021-pol2qm74 3143 4 was be VBD cord-015021-pol2qm74 3143 5 measured measure VBN cord-015021-pol2qm74 3143 6 by by IN cord-015021-pol2qm74 3143 7 ELISA ELISA NNP cord-015021-pol2qm74 3143 8 and and CC cord-015021-pol2qm74 3143 9 IL-6 IL-6 NNP cord-015021-pol2qm74 3143 10 mRNA mRNA NNP cord-015021-pol2qm74 3143 11 was be VBD cord-015021-pol2qm74 3143 12 detected detect VBN cord-015021-pol2qm74 3143 13 by by IN cord-015021-pol2qm74 3143 14 Northern Northern NNP cord-015021-pol2qm74 3143 15 blotting blotting NN cord-015021-pol2qm74 3143 16 after after IN cord-015021-pol2qm74 3143 17 total total JJ cord-015021-pol2qm74 3143 18 RNA RNA NNP cord-015021-pol2qm74 3143 19 was be VBD cord-015021-pol2qm74 3143 20 extracted extract VBN cord-015021-pol2qm74 3143 21 by by IN cord-015021-pol2qm74 3143 22 the the DT cord-015021-pol2qm74 3143 23 Acid Acid NNP cord-015021-pol2qm74 3143 24 Guanidium Guanidium NNP cord-015021-pol2qm74 3143 25 Phenol Phenol NNP cord-015021-pol2qm74 3143 26 Chloroform Chloroform NNP cord-015021-pol2qm74 3143 27 method method NN cord-015021-pol2qm74 3143 28 . . . cord-015021-pol2qm74 3144 1 [ [ -LRB- cord-015021-pol2qm74 3144 2 Results result NNS cord-015021-pol2qm74 3144 3 ] ] -RRB- cord-015021-pol2qm74 3144 4 ( ( -LRB- cord-015021-pol2qm74 3144 5 1 1 CD cord-015021-pol2qm74 3144 6 ) ) -RRB- cord-015021-pol2qm74 3145 1 Serum serum NN cord-015021-pol2qm74 3145 2 IL-6 IL-6 NNP cord-015021-pol2qm74 3145 3 levels level NNS cord-015021-pol2qm74 3145 4 reached reach VBD cord-015021-pol2qm74 3145 5 the the DT cord-015021-pol2qm74 3145 6 maximum maximum JJ cord-015021-pol2qm74 3145 7 concentration concentration NN cord-015021-pol2qm74 3145 8 on on IN cord-015021-pol2qm74 3145 9 the the DT cord-015021-pol2qm74 3145 10 1st 1st JJ cord-015021-pol2qm74 3145 11 postoperative postoperative JJ cord-015021-pol2qm74 3145 12 day day NN cord-015021-pol2qm74 3145 13 in in IN cord-015021-pol2qm74 3145 14 all all DT cord-015021-pol2qm74 3145 15 patients patient NNS cord-015021-pol2qm74 3145 16 . . . cord-015021-pol2qm74 3146 1 ( ( -LRB- cord-015021-pol2qm74 3146 2 2 2 LS cord-015021-pol2qm74 3146 3 ) ) -RRB- cord-015021-pol2qm74 3147 1 The the DT cord-015021-pol2qm74 3147 2 IL-6 IL-6 NNP cord-015021-pol2qm74 3147 3 peak peak NN cord-015021-pol2qm74 3147 4 was be VBD cord-015021-pol2qm74 3147 5 significantly significantly RB cord-015021-pol2qm74 3147 6 correlated correlate VBN cord-015021-pol2qm74 3147 7 with with IN cord-015021-pol2qm74 3147 8 surgical surgical JJ cord-015021-pol2qm74 3147 9 trauma trauma NN cord-015021-pol2qm74 3147 10 as as IN cord-015021-pol2qm74 3147 11 defined define VBN cord-015021-pol2qm74 3147 12 by by IN cord-015021-pol2qm74 3147 13 the the DT cord-015021-pol2qm74 3147 14 operation operation NN cord-015021-pol2qm74 3147 15 length length NN cord-015021-pol2qm74 3147 16 and and CC cord-015021-pol2qm74 3147 17 the the DT cord-015021-pol2qm74 3147 18 volume volume NN cord-015021-pol2qm74 3147 19 of of IN cord-015021-pol2qm74 3147 20 blood blood NN cord-015021-pol2qm74 3147 21 loss loss NN cord-015021-pol2qm74 3147 22 during during IN cord-015021-pol2qm74 3147 23 operation operation NN cord-015021-pol2qm74 3147 24 ( ( -LRB- cord-015021-pol2qm74 3147 25 r=0.554 r=0.554 NNS cord-015021-pol2qm74 3147 26 , , , cord-015021-pol2qm74 3147 27 p<0.01 p<0.01 NNP cord-015021-pol2qm74 3147 28 , , , cord-015021-pol2qm74 3147 29 r=0.427 r=0.427 NN cord-015021-pol2qm74 3147 30 , , , cord-015021-pol2qm74 3147 31 p<0.01 p<0.01 NNP cord-015021-pol2qm74 3147 32 , , , cord-015021-pol2qm74 3147 33 respectively respectively RB cord-015021-pol2qm74 3147 34 ) ) -RRB- cord-015021-pol2qm74 3147 35 . . . cord-015021-pol2qm74 3148 1 ( ( -LRB- cord-015021-pol2qm74 3148 2 3 3 LS cord-015021-pol2qm74 3148 3 ) ) -RRB- cord-015021-pol2qm74 3149 1 The the DT cord-015021-pol2qm74 3149 2 peak peak NN cord-015021-pol2qm74 3149 3 concentration concentration NN cord-015021-pol2qm74 3149 4 of of IN cord-015021-pol2qm74 3149 5 serum serum NN cord-015021-pol2qm74 3149 6 IL-6 IL-6 NNP cord-015021-pol2qm74 3149 7 in in IN cord-015021-pol2qm74 3149 8 patients patient NNS cord-015021-pol2qm74 3149 9 undergoing undergo VBG cord-015021-pol2qm74 3149 10 esophagectomy esophagectomy NN cord-015021-pol2qm74 3149 11 was be VBD cord-015021-pol2qm74 3149 12 significantly significantly RB cord-015021-pol2qm74 3149 13 higher high JJR cord-015021-pol2qm74 3149 14 than than IN cord-015021-pol2qm74 3149 15 in in IN cord-015021-pol2qm74 3149 16 those those DT cord-015021-pol2qm74 3149 17 undergoing undergo VBG cord-015021-pol2qm74 3149 18 pancreaticoduodenectomy pancreaticoduodenectomy NN cord-015021-pol2qm74 3149 19 ( ( -LRB- cord-015021-pol2qm74 3149 20 p<0.05 p<0.05 NNP cord-015021-pol2qm74 3149 21 ) ) -RRB- cord-015021-pol2qm74 3149 22 , , , cord-015021-pol2qm74 3149 23 despite despite IN cord-015021-pol2qm74 3149 24 a a DT cord-015021-pol2qm74 3149 25 similar similar JJ cord-015021-pol2qm74 3149 26 degree degree NN cord-015021-pol2qm74 3149 27 of of IN cord-015021-pol2qm74 3149 28 surgical surgical JJ cord-015021-pol2qm74 3149 29 trauma trauma NN cord-015021-pol2qm74 3149 30 . . . cord-015021-pol2qm74 3150 1 ( ( -LRB- cord-015021-pol2qm74 3150 2 4 4 LS cord-015021-pol2qm74 3150 3 ) ) -RRB- cord-015021-pol2qm74 3151 1 Peak Peak NNP cord-015021-pol2qm74 3151 2 1L-6 1l-6 JJ cord-015021-pol2qm74 3151 3 concentration concentration NN cord-015021-pol2qm74 3151 4 observed observe VBD cord-015021-pol2qm74 3151 5 in in IN cord-015021-pol2qm74 3151 6 a a DT cord-015021-pol2qm74 3151 7 patient patient NN cord-015021-pol2qm74 3151 8 who who WP cord-015021-pol2qm74 3151 9 underwent undergo VBD cord-015021-pol2qm74 3151 10 esophagectomy esophagectomy NN cord-015021-pol2qm74 3151 11 was be VBD cord-015021-pol2qm74 3151 12 about about RB cord-015021-pol2qm74 3151 13 100 100 CD cord-015021-pol2qm74 3151 14 fold fold VBP cord-015021-pol2qm74 3151 15 greater great JJR cord-015021-pol2qm74 3151 16 in in IN cord-015021-pol2qm74 3151 17 the the DT cord-015021-pol2qm74 3151 18 drain drain NN cord-015021-pol2qm74 3151 19 fluid fluid NN cord-015021-pol2qm74 3151 20 of of IN cord-015021-pol2qm74 3151 21 thorax thorax NN cord-015021-pol2qm74 3151 22 than than IN cord-015021-pol2qm74 3151 23 in in IN cord-015021-pol2qm74 3151 24 the the DT cord-015021-pol2qm74 3151 25 peripheral peripheral JJ cord-015021-pol2qm74 3151 26 blood blood NN cord-015021-pol2qm74 3151 27 . . . cord-015021-pol2qm74 3152 1 ( ( -LRB- cord-015021-pol2qm74 3152 2 5 5 LS cord-015021-pol2qm74 3152 3 ) ) -RRB- cord-015021-pol2qm74 3152 4 IL-6 IL-6 NNP cord-015021-pol2qm74 3152 5 mRNA mRNA NNP cord-015021-pol2qm74 3152 6 was be VBD cord-015021-pol2qm74 3152 7 demonstrated demonstrate VBN cord-015021-pol2qm74 3152 8 in in IN cord-015021-pol2qm74 3152 9 leukocytes leukocyte NNS cord-015021-pol2qm74 3152 10 from from IN cord-015021-pol2qm74 3152 11 thoracic thoracic JJ cord-015021-pol2qm74 3152 12 and and CC cord-015021-pol2qm74 3152 13 abdominal abdominal JJ cord-015021-pol2qm74 3152 14 exudate exudate NN cord-015021-pol2qm74 3152 15 at at IN cord-015021-pol2qm74 3152 16 6 6 CD cord-015021-pol2qm74 3152 17 , , , cord-015021-pol2qm74 3152 18 24 24 CD cord-015021-pol2qm74 3152 19 and and CC cord-015021-pol2qm74 3152 20 48 48 CD cord-015021-pol2qm74 3152 21 hours hour NNS cord-015021-pol2qm74 3152 22 after after IN cord-015021-pol2qm74 3152 23 surgery surgery NN cord-015021-pol2qm74 3152 24 . . . cord-015021-pol2qm74 3153 1 In in IN cord-015021-pol2qm74 3153 2 contrast contrast NN cord-015021-pol2qm74 3153 3 , , , cord-015021-pol2qm74 3153 4 IL-6 IL-6 NNP cord-015021-pol2qm74 3153 5 mRNA mRNA NNP cord-015021-pol2qm74 3153 6 could could MD cord-015021-pol2qm74 3153 7 not not RB cord-015021-pol2qm74 3153 8 be be VB cord-015021-pol2qm74 3153 9 detected detect VBN cord-015021-pol2qm74 3153 10 in in IN cord-015021-pol2qm74 3153 11 leukocytes leukocyte NNS cord-015021-pol2qm74 3153 12 from from IN cord-015021-pol2qm74 3153 13 the the DT cord-015021-pol2qm74 3153 14 peripheral peripheral JJ cord-015021-pol2qm74 3153 15 blood blood NN cord-015021-pol2qm74 3153 16 . . . cord-015021-pol2qm74 3154 1 [ [ -LRB- cord-015021-pol2qm74 3154 2 Conclusion conclusion NN cord-015021-pol2qm74 3154 3 ] ] -RRB- cord-015021-pol2qm74 3154 4 IL-6 IL-6 NNP cord-015021-pol2qm74 3154 5 is be VBZ cord-015021-pol2qm74 3154 6 mainly mainly RB cord-015021-pol2qm74 3154 7 produced produce VBN cord-015021-pol2qm74 3154 8 in in IN cord-015021-pol2qm74 3154 9 the the DT cord-015021-pol2qm74 3154 10 operative operative JJ cord-015021-pol2qm74 3154 11 field field NN cord-015021-pol2qm74 3154 12 and and CC cord-015021-pol2qm74 3154 13 subsequently subsequently RB cord-015021-pol2qm74 3154 14 enter enter VB cord-015021-pol2qm74 3154 15 the the DT cord-015021-pol2qm74 3154 16 peripheral peripheral JJ cord-015021-pol2qm74 3154 17 blood blood NN cord-015021-pol2qm74 3154 18 to to TO cord-015021-pol2qm74 3154 19 induce induce VB cord-015021-pol2qm74 3154 20 cytokinemia cytokinemia NN cord-015021-pol2qm74 3154 21 . . . cord-015021-pol2qm74 3155 1 The the DT cord-015021-pol2qm74 3155 2 operation operation NN cord-015021-pol2qm74 3155 3 length length NN cord-015021-pol2qm74 3155 4 , , , cord-015021-pol2qm74 3155 5 volume volume NN cord-015021-pol2qm74 3155 6 of of IN cord-015021-pol2qm74 3155 7 blood blood NN cord-015021-pol2qm74 3155 8 loss loss NN cord-015021-pol2qm74 3155 9 and and CC cord-015021-pol2qm74 3155 10 thoracotomy thoracotomy NN cord-015021-pol2qm74 3155 11 are be VBP cord-015021-pol2qm74 3155 12 factors factor NNS cord-015021-pol2qm74 3155 13 influencing influence VBG cord-015021-pol2qm74 3155 14 the the DT cord-015021-pol2qm74 3155 15 concentration concentration NN cord-015021-pol2qm74 3155 16 of of IN cord-015021-pol2qm74 3155 17 cytokine cytokine NN cord-015021-pol2qm74 3155 18 in in IN cord-015021-pol2qm74 3155 19 the the DT cord-015021-pol2qm74 3155 20 blood blood NN cord-015021-pol2qm74 3155 21 . . . cord-015021-pol2qm74 3156 1 Zaragoza Zaragoza NNP cord-015021-pol2qm74 3157 1 SPAIN SPAIN NNP cord-015021-pol2qm74 3157 2 Age Age NNP cord-015021-pol2qm74 3157 3 may may MD cord-015021-pol2qm74 3157 4 be be VB cord-015021-pol2qm74 3157 5 an an DT cord-015021-pol2qm74 3157 6 important important JJ cord-015021-pol2qm74 3157 7 factor factor NN cord-015021-pol2qm74 3157 8 influencing influence VBG cord-015021-pol2qm74 3157 9 the the DT cord-015021-pol2qm74 3157 10 function function NN cord-015021-pol2qm74 3157 11 of of IN cord-015021-pol2qm74 3157 12 immunocompeteut immunocompeteut JJ cord-015021-pol2qm74 3157 13 cells cell NNS cord-015021-pol2qm74 3157 14 releasing release VBG cord-015021-pol2qm74 3157 15 cytokines cytokine NNS cord-015021-pol2qm74 3157 16 after after IN cord-015021-pol2qm74 3157 17 both both CC cord-015021-pol2qm74 3157 18 accidental accidental JJ cord-015021-pol2qm74 3157 19 and and CC cord-015021-pol2qm74 3157 20 surgical surgical JJ cord-015021-pol2qm74 3157 21 trauma trauma NN cord-015021-pol2qm74 3158 1 The the DT cord-015021-pol2qm74 3158 2 aim aim NN cord-015021-pol2qm74 3158 3 of of IN cord-015021-pol2qm74 3158 4 the the DT cord-015021-pol2qm74 3158 5 present present JJ cord-015021-pol2qm74 3158 6 paper paper NN cord-015021-pol2qm74 3158 7 is be VBZ cord-015021-pol2qm74 3158 8 to to TO cord-015021-pol2qm74 3158 9 ascertain ascertain VB cord-015021-pol2qm74 3158 10 if if IN cord-015021-pol2qm74 3158 11 patients patient NNS cord-015021-pol2qm74 3158 12 ( ( -LRB- cord-015021-pol2qm74 3158 13 PTS PTS NNP cord-015021-pol2qm74 3158 14 ) ) -RRB- cord-015021-pol2qm74 3158 15 over over IN cord-015021-pol2qm74 3158 16 60 60 CD cord-015021-pol2qm74 3158 17 years year NNS cord-015021-pol2qm74 3158 18 old old JJ cord-015021-pol2qm74 3158 19 show show VBP cord-015021-pol2qm74 3158 20 a a DT cord-015021-pol2qm74 3158 21 different different JJ cord-015021-pol2qm74 3158 22 serum serum NN cord-015021-pol2qm74 3158 23 level level NN cord-015021-pol2qm74 3158 24 cytokine cytokine NN cord-015021-pol2qm74 3158 25 pattern pattern NN cord-015021-pol2qm74 3158 26 than than IN cord-015021-pol2qm74 3158 27 PTS PTS NNP cord-015021-pol2qm74 3158 28 under under IN cord-015021-pol2qm74 3158 29 60 60 CD cord-015021-pol2qm74 3158 30 after after IN cord-015021-pol2qm74 3158 31 a a DT cord-015021-pol2qm74 3158 32 standard standard JJ cord-015021-pol2qm74 3158 33 surgical surgical JJ cord-015021-pol2qm74 3158 34 procedure procedure NN cord-015021-pol2qm74 3158 35 considered consider VBN cord-015021-pol2qm74 3158 36 as as IN cord-015021-pol2qm74 3158 37 a a DT cord-015021-pol2qm74 3158 38 " " `` cord-015021-pol2qm74 3158 39 medium medium JJ cord-015021-pol2qm74 3158 40 strength strength NN cord-015021-pol2qm74 3158 41 trauma trauma NN cord-015021-pol2qm74 3158 42 " " '' cord-015021-pol2qm74 3158 43 . . . cord-015021-pol2qm74 3159 1 PATIENTS patient NNS cord-015021-pol2qm74 3159 2 AND and CC cord-015021-pol2qm74 3159 3 METHODS method NNS cord-015021-pol2qm74 3159 4 : : : cord-015021-pol2qm74 3160 1 33 33 CD cord-015021-pol2qm74 3160 2 PTS(22 PTS(22 NNP cord-015021-pol2qm74 3160 3 females female NNS cord-015021-pol2qm74 3161 1 11 11 CD cord-015021-pol2qm74 3161 2 males)with males)with NNP cord-015021-pol2qm74 3161 3 gallstone gallstone NN cord-015021-pol2qm74 3161 4 disease disease NN cord-015021-pol2qm74 3161 5 were be VBD cord-015021-pol2qm74 3161 6 perspectively perspectively RB cord-015021-pol2qm74 3161 7 studied study VBN cord-015021-pol2qm74 3161 8 , , , cord-015021-pol2qm74 3161 9 PTS PTS NNP cord-015021-pol2qm74 3161 10 were be VBD cord-015021-pol2qm74 3161 11 allotted allot VBN cord-015021-pol2qm74 3161 12 in in IN cord-015021-pol2qm74 3161 13 two two CD cord-015021-pol2qm74 3161 14 groups group NNS cord-015021-pol2qm74 3161 15 : : : cord-015021-pol2qm74 3162 1 Gr Gr NNP cord-015021-pol2qm74 3162 2 . . . cord-015021-pol2qm74 3163 1 A:17 A:17 NNP cord-015021-pol2qm74 3163 2 PTS PTS NNP cord-015021-pol2qm74 3163 3 under under IN cord-015021-pol2qm74 3163 4 60 60 CD cord-015021-pol2qm74 3163 5 years(mean years(mean CD cord-015021-pol2qm74 3163 6 age:49.5 age:49.5 XX cord-015021-pol2qm74 3164 1 + + CC cord-015021-pol2qm74 3165 1 -7)Gr -7)Gr NNP cord-015021-pol2qm74 3165 2 . . . cord-015021-pol2qm74 3166 1 B:16 B:16 NNP cord-015021-pol2qm74 3166 2 PTS PTS NNP cord-015021-pol2qm74 3166 3 over over IN cord-015021-pol2qm74 3166 4 60 60 CD cord-015021-pol2qm74 3166 5 years(mean years(mean JJ cord-015021-pol2qm74 3166 6 age:65.5_+5 age:65.5_+5 NNP cord-015021-pol2qm74 3166 7 ) ) -RRB- cord-015021-pol2qm74 3166 8 . . . cord-015021-pol2qm74 3167 1 All all DT cord-015021-pol2qm74 3167 2 PTS PTS NNP cord-015021-pol2qm74 3167 3 underwent undergo VBD cord-015021-pol2qm74 3167 4 cholecystectomy cholecystectomy NN cord-015021-pol2qm74 3167 5 and and CC cord-015021-pol2qm74 3167 6 cholangiography cholangiography NN cord-015021-pol2qm74 3167 7 . . . cord-015021-pol2qm74 3168 1 6 6 CD cord-015021-pol2qm74 3168 2 PTS pts NN cord-015021-pol2qm74 3168 3 in in IN cord-015021-pol2qm74 3168 4 Gr Gr NNP cord-015021-pol2qm74 3168 5 . . . cord-015021-pol2qm74 3169 1 A a NN cord-015021-pol2qm74 3169 2 and and CC cord-015021-pol2qm74 3169 3 7 7 CD cord-015021-pol2qm74 3169 4 PTS PTS NNP cord-015021-pol2qm74 3169 5 in in IN cord-015021-pol2qm74 3169 6 Gr Gr NNP cord-015021-pol2qm74 3169 7 . . . cord-015021-pol2qm74 3170 1 B b NN cord-015021-pol2qm74 3170 2 underwent undergo VBD cord-015021-pol2qm74 3170 3 common common JJ cord-015021-pol2qm74 3170 4 duct duct NN cord-015021-pol2qm74 3170 5 exploration exploration NN cord-015021-pol2qm74 3170 6 . . . cord-015021-pol2qm74 3171 1 1 1 CD cord-015021-pol2qm74 3171 2 spbintercctomy spbintercctomy NN cord-015021-pol2qm74 3171 3 was be VBD cord-015021-pol2qm74 3171 4 performed perform VBN cord-015021-pol2qm74 3171 5 in in IN cord-015021-pol2qm74 3171 6 each each DT cord-015021-pol2qm74 3171 7 group group NN cord-015021-pol2qm74 3171 8 . . . cord-015021-pol2qm74 3172 1 On on IN cord-015021-pol2qm74 3172 2 the the DT cord-015021-pol2qm74 3172 3 day day NN cord-015021-pol2qm74 3172 4 of of IN cord-015021-pol2qm74 3172 5 surgery surgery NN cord-015021-pol2qm74 3172 6 ( ( -LRB- cord-015021-pol2qm74 3172 7 PRE PRE NNP cord-015021-pol2qm74 3172 8 ) ) -RRB- cord-015021-pol2qm74 3172 9 and and CC cord-015021-pol2qm74 3172 10 on on IN cord-015021-pol2qm74 3172 11 the the DT cord-015021-pol2qm74 3172 12 1st 1st JJ cord-015021-pol2qm74 3172 13 and and CC cord-015021-pol2qm74 3172 14 7th 7th JJ cord-015021-pol2qm74 3172 15 postoperative postoperative JJ cord-015021-pol2qm74 3172 16 day(lEO day(lEO '' cord-015021-pol2qm74 3172 17 , , , cord-015021-pol2qm74 3172 18 7PO 7PO NNP cord-015021-pol2qm74 3172 19 ) ) -RRB- cord-015021-pol2qm74 3172 20 : : : cord-015021-pol2qm74 3172 21 percentages percentage NNS cord-015021-pol2qm74 3172 22 of of IN cord-015021-pol2qm74 3172 23 CD19 CD19 NNP cord-015021-pol2qm74 3172 24 , , , cord-015021-pol2qm74 3172 25 CD5 CD5 NNP cord-015021-pol2qm74 3172 26 , , , cord-015021-pol2qm74 3172 27 CD4 CD4 NNP cord-015021-pol2qm74 3172 28 , , , cord-015021-pol2qm74 3172 29 CD8 CD8 NNP cord-015021-pol2qm74 3172 30 and and CC cord-015021-pol2qm74 3172 31 CD16 CD16 NNP cord-015021-pol2qm74 3172 32 cells cell NNS cord-015021-pol2qm74 3172 33 we -PRON- PRP cord-015021-pol2qm74 3172 34 measured measure VBN cord-015021-pol2qm74 3172 35 by by IN cord-015021-pol2qm74 3172 36 means mean NNS cord-015021-pol2qm74 3172 37 of of IN cord-015021-pol2qm74 3172 38 flow flow NN cord-015021-pol2qm74 3172 39 cytometry cytometry NN cord-015021-pol2qm74 3172 40 using use VBG cord-015021-pol2qm74 3172 41 MoAb MoAb NNP cord-015021-pol2qm74 3172 42 . . . cord-015021-pol2qm74 3173 1 and and CC cord-015021-pol2qm74 3173 2 levels level NNS cord-015021-pol2qm74 3173 3 of of IN cord-015021-pol2qm74 3173 4 IL-1 IL-1 NNP cord-015021-pol2qm74 3173 5 , , , cord-015021-pol2qm74 3173 6 IL-4 IL-4 NNP cord-015021-pol2qm74 3173 7 , , , cord-015021-pol2qm74 3173 8 IL-6 IL-6 NNP cord-015021-pol2qm74 3173 9 and and CC cord-015021-pol2qm74 3173 10 TNF TNF NNP cord-015021-pol2qm74 3173 11 " " '' cord-015021-pol2qm74 3173 12 in in IN cord-015021-pol2qm74 3173 13 vivo vivo NN cord-015021-pol2qm74 3173 14 " " '' cord-015021-pol2qm74 3173 15 by by IN cord-015021-pol2qm74 3173 16 ELISA ELISA NNP cord-015021-pol2qm74 3173 17 using use VBG cord-015021-pol2qm74 3173 18 MoAb MoAb NNP cord-015021-pol2qm74 3173 19 . . . cord-015021-pol2qm74 3174 1 RESULTS result NNS cord-015021-pol2qm74 3174 2 : : : cord-015021-pol2qm74 3175 1 ERE ERE NNP cord-015021-pol2qm74 3175 2 : : : cord-015021-pol2qm74 3176 1 CD16 CD16 NNP cord-015021-pol2qm74 3176 2 % % NN cord-015021-pol2qm74 3176 3 was be VBD cord-015021-pol2qm74 3176 4 5.3_+3 5.3_+3 CD cord-015021-pol2qm74 3176 5 in in IN cord-015021-pol2qm74 3176 6 Gr Gr NNP cord-015021-pol2qm74 3176 7 . . . cord-015021-pol2qm74 3177 1 A a NN cord-015021-pol2qm74 3177 2 and and CC cord-015021-pol2qm74 3177 3 7 7 CD cord-015021-pol2qm74 3177 4 . . NN cord-015021-pol2qm74 3177 5 5 5 CD cord-015021-pol2qm74 3177 6 _SP cord-015021-pol2qm74 3178 1 Objectives objective NNS cord-015021-pol2qm74 3178 2 of of IN cord-015021-pol2qm74 3178 3 the the DT cord-015021-pol2qm74 3178 4 study study NN cord-015021-pol2qm74 3178 5 . . . cord-015021-pol2qm74 3179 1 After after IN cord-015021-pol2qm74 3179 2 surgery surgery NN cord-015021-pol2qm74 3179 3 for for IN cord-015021-pol2qm74 3179 4 esophageal esophageal JJ cord-015021-pol2qm74 3179 5 cancer cancer NN cord-015021-pol2qm74 3179 6 multiple multiple JJ cord-015021-pol2qm74 3179 7 organ organ NN cord-015021-pol2qm74 3179 8 damage damage NN cord-015021-pol2qm74 3179 9 has have VBZ cord-015021-pol2qm74 3179 10 been be VBN cord-015021-pol2qm74 3179 11 reported report VBN cord-015021-pol2qm74 3179 12 to to TO cord-015021-pol2qm74 3179 13 be be VB cord-015021-pol2qm74 3179 14 caused cause VBN cord-015021-pol2qm74 3179 15 by by IN cord-015021-pol2qm74 3179 16 polymorphonuclear polymorphonuclear JJ cord-015021-pol2qm74 3179 17 leukocyte leukocyte NN cord-015021-pol2qm74 3179 18 ( ( -LRB- cord-015021-pol2qm74 3179 19 PMN)-mediated pmn)-mediate VBN cord-015021-pol2qm74 3179 20 injury injury NN cord-015021-pol2qm74 3179 21 . . . cord-015021-pol2qm74 3180 1 We -PRON- PRP cord-015021-pol2qm74 3180 2 measured measure VBD cord-015021-pol2qm74 3180 3 serum serum NN cord-015021-pol2qm74 3180 4 granulocyte granulocyte NN cord-015021-pol2qm74 3180 5 colony colony NN cord-015021-pol2qm74 3180 6 - - HYPH cord-015021-pol2qm74 3180 7 stimulating stimulate VBG cord-015021-pol2qm74 3180 8 factor factor NN cord-015021-pol2qm74 3180 9 ( ( -LRB- cord-015021-pol2qm74 3180 10 G G NNP cord-015021-pol2qm74 3180 11 - - HYPH cord-015021-pol2qm74 3180 12 CSF CSF NNP cord-015021-pol2qm74 3180 13 ) ) -RRB- cord-015021-pol2qm74 3180 14 and and CC cord-015021-pol2qm74 3180 15 interleukin interleukin NN cord-015021-pol2qm74 3180 16 8 8 CD cord-015021-pol2qm74 3180 17 ( ( -LRB- cord-015021-pol2qm74 3180 18 IL-8 il-8 NN cord-015021-pol2qm74 3180 19 ) ) -RRB- cord-015021-pol2qm74 3180 20 levels level NNS cord-015021-pol2qm74 3180 21 to to TO cord-015021-pol2qm74 3180 22 determine determine VB cord-015021-pol2qm74 3180 23 a a DT cord-015021-pol2qm74 3180 24 role role NN cord-015021-pol2qm74 3180 25 of of IN cord-015021-pol2qm74 3180 26 G G NNP cord-015021-pol2qm74 3180 27 - - HYPH cord-015021-pol2qm74 3180 28 CSF CSF NNP cord-015021-pol2qm74 3180 29 and and CC cord-015021-pol2qm74 3180 30 IL-8 IL-8 NNP cord-015021-pol2qm74 3180 31 in in IN cord-015021-pol2qm74 3180 32 PMN PMN NNP cord-015021-pol2qm74 3180 33 function function NN cord-015021-pol2qm74 3180 34 after after IN cord-015021-pol2qm74 3180 35 surgery surgery NN cord-015021-pol2qm74 3180 36 for for IN cord-015021-pol2qm74 3180 37 esophageal esophageal JJ cord-015021-pol2qm74 3180 38 cancer cancer NN cord-015021-pol2qm74 3180 39 . . . cord-015021-pol2qm74 3181 1 Materials material NNS cord-015021-pol2qm74 3181 2 and and CC cord-015021-pol2qm74 3181 3 Methods method NNS cord-015021-pol2qm74 3181 4 . . . cord-015021-pol2qm74 3182 1 Peripheral Peripheral NNP cord-015021-pol2qm74 3182 2 PMN PMN NNP cord-015021-pol2qm74 3182 3 counts count VBZ cord-015021-pol2qm74 3182 4 , , , cord-015021-pol2qm74 3182 5 peripheral peripheral JJ cord-015021-pol2qm74 3182 6 PMN PMN NNP cord-015021-pol2qm74 3182 7 chemiluminescence chemiluminescence NN cord-015021-pol2qm74 3182 8 , , , cord-015021-pol2qm74 3182 9 serum serum NN cord-015021-pol2qm74 3182 10 G G NNP cord-015021-pol2qm74 3182 11 - - HYPH cord-015021-pol2qm74 3182 12 CSF csf NN cord-015021-pol2qm74 3182 13 levels level NNS cord-015021-pol2qm74 3182 14 , , , cord-015021-pol2qm74 3182 15 and and CC cord-015021-pol2qm74 3182 16 serum serum NN cord-015021-pol2qm74 3182 17 IL-8 il-8 NN cord-015021-pol2qm74 3182 18 levels level NNS cord-015021-pol2qm74 3182 19 were be VBD cord-015021-pol2qm74 3182 20 measured measure VBN cord-015021-pol2qm74 3182 21 before before RB cord-015021-pol2qm74 3182 22 and and CC cord-015021-pol2qm74 3182 23 after after IN cord-015021-pol2qm74 3182 24 surgery surgery NN cord-015021-pol2qm74 3182 25 in in IN cord-015021-pol2qm74 3182 26 12 12 CD cord-015021-pol2qm74 3182 27 patients patient NNS cord-015021-pol2qm74 3182 28 with with IN cord-015021-pol2qm74 3182 29 esophageal esophageal JJ cord-015021-pol2qm74 3182 30 cancer cancer NN cord-015021-pol2qm74 3182 31 ( ( -LRB- cord-015021-pol2qm74 3182 32 EC EC NNP cord-015021-pol2qm74 3182 33 ) ) -RRB- cord-015021-pol2qm74 3182 34 , , , cord-015021-pol2qm74 3182 35 and and CC cord-015021-pol2qm74 3182 36 12 12 CD cord-015021-pol2qm74 3182 37 patients patient NNS cord-015021-pol2qm74 3182 38 of of IN cord-015021-pol2qm74 3182 39 gastric gastric JJ cord-015021-pol2qm74 3182 40 cancer cancer NN cord-015021-pol2qm74 3182 41 ( ( -LRB- cord-015021-pol2qm74 3182 42 GC GC NNP cord-015021-pol2qm74 3182 43 ) ) -RRB- cord-015021-pol2qm74 3182 44 . . . cord-015021-pol2qm74 3183 1 Esophagectomy Esophagectomy NNP cord-015021-pol2qm74 3183 2 with with IN cord-015021-pol2qm74 3183 3 thoracotomy thoracotomy NN cord-015021-pol2qm74 3183 4 and and CC cord-015021-pol2qm74 3183 5 laparotomy laparotomy NN cord-015021-pol2qm74 3183 6 were be VBD cord-015021-pol2qm74 3183 7 performed perform VBN cord-015021-pol2qm74 3183 8 for for IN cord-015021-pol2qm74 3183 9 patients patient NNS cord-015021-pol2qm74 3183 10 with with IN cord-015021-pol2qm74 3183 11 EC EC NNP cord-015021-pol2qm74 3183 12 , , , cord-015021-pol2qm74 3183 13 while while IN cord-015021-pol2qm74 3183 14 subtotal subtotal NN cord-015021-pol2qm74 3183 15 gastrectomy gastrectomy NN cord-015021-pol2qm74 3183 16 with with IN cord-015021-pol2qm74 3183 17 laparotomy laparotomy NN cord-015021-pol2qm74 3183 18 were be VBD cord-015021-pol2qm74 3183 19 performed perform VBN cord-015021-pol2qm74 3183 20 for for IN cord-015021-pol2qm74 3183 21 patients patient NNS cord-015021-pol2qm74 3183 22 with with IN cord-015021-pol2qm74 3183 23 GC GC NNP cord-015021-pol2qm74 3183 24 . . . cord-015021-pol2qm74 3184 1 Results result NNS cord-015021-pol2qm74 3184 2 . . . cord-015021-pol2qm74 3185 1 Peripheral Peripheral NNP cord-015021-pol2qm74 3185 2 PMN PMN NNP cord-015021-pol2qm74 3185 3 counts count VBZ cord-015021-pol2qm74 3185 4 ( ( -LRB- cord-015021-pol2qm74 3185 5 p<0.01 p<0.01 NNP cord-015021-pol2qm74 3185 6 ) ) -RRB- cord-015021-pol2qm74 3185 7 and and CC cord-015021-pol2qm74 3185 8 peripheral peripheral JJ cord-015021-pol2qm74 3185 9 PMN PMN NNP cord-015021-pol2qm74 3185 10 chemiluminescence chemiluminescence NN cord-015021-pol2qm74 3185 11 ( ( -LRB- cord-015021-pol2qm74 3185 12 p<0.05 p<0.05 CD cord-015021-pol2qm74 3185 13 ) ) -RRB- cord-015021-pol2qm74 3185 14 of of IN cord-015021-pol2qm74 3185 15 patients patient NNS cord-015021-pol2qm74 3185 16 with with IN cord-015021-pol2qm74 3185 17 EC EC NNP cord-015021-pol2qm74 3185 18 were be VBD cord-015021-pol2qm74 3185 19 significantly significantly RB cord-015021-pol2qm74 3185 20 decreased decrease VBN cord-015021-pol2qm74 3185 21 compared compare VBN cord-015021-pol2qm74 3185 22 to to IN cord-015021-pol2qm74 3185 23 those those DT cord-015021-pol2qm74 3185 24 of of IN cord-015021-pol2qm74 3185 25 patients patient NNS cord-015021-pol2qm74 3185 26 with with IN cord-015021-pol2qm74 3185 27 GC GC NNP cord-015021-pol2qm74 3185 28 at at IN cord-015021-pol2qm74 3185 29 4 4 CD cord-015021-pol2qm74 3185 30 and and CC cord-015021-pol2qm74 3185 31 8 8 CD cord-015021-pol2qm74 3185 32 hours hour NNS cord-015021-pol2qm74 3185 33 after after IN cord-015021-pol2qm74 3185 34 surgery surgery NN cord-015021-pol2qm74 3185 35 . . . cord-015021-pol2qm74 3186 1 Serum serum NN cord-015021-pol2qm74 3186 2 G G NNP cord-015021-pol2qm74 3186 3 - - HYPH cord-015021-pol2qm74 3186 4 CSF csf NN cord-015021-pol2qm74 3186 5 levels level NNS cord-015021-pol2qm74 3186 6 of of IN cord-015021-pol2qm74 3186 7 patients patient NNS cord-015021-pol2qm74 3186 8 with with IN cord-015021-pol2qm74 3186 9 EC EC NNP cord-015021-pol2qm74 3186 10 were be VBD cord-015021-pol2qm74 3186 11 significantly significantly RB cord-015021-pol2qm74 3186 12 ( ( -LRB- cord-015021-pol2qm74 3186 13 p<0.01 p<0.01 NNP cord-015021-pol2qm74 3186 14 ) ) -RRB- cord-015021-pol2qm74 3186 15 increased increase VBD cord-015021-pol2qm74 3186 16 compared compare VBN cord-015021-pol2qm74 3186 17 to to IN cord-015021-pol2qm74 3186 18 those those DT cord-015021-pol2qm74 3186 19 of of IN cord-015021-pol2qm74 3186 20 patients patient NNS cord-015021-pol2qm74 3186 21 with with IN cord-015021-pol2qm74 3186 22 GC GC NNP cord-015021-pol2qm74 3186 23 at at IN cord-015021-pol2qm74 3186 24 4 4 CD cord-015021-pol2qm74 3186 25 and and CC cord-015021-pol2qm74 3186 26 8 8 CD cord-015021-pol2qm74 3186 27 hours hour NNS cord-015021-pol2qm74 3186 28 after after IN cord-015021-pol2qm74 3186 29 surgery surgery NN cord-015021-pol2qm74 3186 30 . . . cord-015021-pol2qm74 3187 1 Serum serum NN cord-015021-pol2qm74 3187 2 IL-8 il-8 NN cord-015021-pol2qm74 3187 3 levels level NNS cord-015021-pol2qm74 3187 4 of of IN cord-015021-pol2qm74 3187 5 patients patient NNS cord-015021-pol2qm74 3187 6 with with IN cord-015021-pol2qm74 3187 7 EC EC NNP cord-015021-pol2qm74 3187 8 were be VBD cord-015021-pol2qm74 3187 9 significantly significantly RB cord-015021-pol2qm74 3187 10 ( ( -LRB- cord-015021-pol2qm74 3187 11 p<0.01 p<0.01 NNP cord-015021-pol2qm74 3187 12 ) ) -RRB- cord-015021-pol2qm74 3187 13 increased increase VBD cord-015021-pol2qm74 3187 14 compared compare VBN cord-015021-pol2qm74 3187 15 to to IN cord-015021-pol2qm74 3187 16 those those DT cord-015021-pol2qm74 3187 17 of of IN cord-015021-pol2qm74 3187 18 patients patient NNS cord-015021-pol2qm74 3187 19 with with IN cord-015021-pol2qm74 3187 20 GC GC NNP cord-015021-pol2qm74 3187 21 at at IN cord-015021-pol2qm74 3187 22 4 4 CD cord-015021-pol2qm74 3187 23 , , , cord-015021-pol2qm74 3187 24 8 8 CD cord-015021-pol2qm74 3187 25 and and CC cord-015021-pol2qm74 3187 26 24 24 CD cord-015021-pol2qm74 3187 27 hours hour NNS cord-015021-pol2qm74 3187 28 after after IN cord-015021-pol2qm74 3187 29 surgery surgery NN cord-015021-pol2qm74 3187 30 . . . cord-015021-pol2qm74 3188 1 Significant significant JJ cord-015021-pol2qm74 3188 2 inverse inverse JJ cord-015021-pol2qm74 3188 3 correlations correlation NNS cord-015021-pol2qm74 3188 4 ( ( -LRB- cord-015021-pol2qm74 3188 5 p<0.0l p<0.0l NNP cord-015021-pol2qm74 3188 6 ) ) -RRB- cord-015021-pol2qm74 3188 7 between between IN cord-015021-pol2qm74 3188 8 peripheral peripheral JJ cord-015021-pol2qm74 3188 9 PMN PMN NNP cord-015021-pol2qm74 3188 10 count count NN cord-015021-pol2qm74 3188 11 and and CC cord-015021-pol2qm74 3188 12 serum serum NN cord-015021-pol2qm74 3188 13 G G NNP cord-015021-pol2qm74 3188 14 - - HYPH cord-015021-pol2qm74 3188 15 CSF CSF NNP cord-015021-pol2qm74 3188 16 and and CC cord-015021-pol2qm74 3188 17 IL-8 IL-8 NNP cord-015021-pol2qm74 3188 18 levels level NNS cord-015021-pol2qm74 3188 19 were be VBD cord-015021-pol2qm74 3188 20 seen see VBN cord-015021-pol2qm74 3188 21 at at IN cord-015021-pol2qm74 3188 22 4 4 CD cord-015021-pol2qm74 3188 23 hours hour NNS cord-015021-pol2qm74 3188 24 after after IN cord-015021-pol2qm74 3188 25 surgery surgery NN cord-015021-pol2qm74 3188 26 . . . cord-015021-pol2qm74 3189 1 Conclusion conclusion NN cord-015021-pol2qm74 3189 2 . . . cord-015021-pol2qm74 3190 1 These these DT cord-015021-pol2qm74 3190 2 results result NNS cord-015021-pol2qm74 3190 3 suggest suggest VBP cord-015021-pol2qm74 3190 4 that that IN cord-015021-pol2qm74 3190 5 many many JJ cord-015021-pol2qm74 3190 6 circulating circulate VBG cord-015021-pol2qm74 3190 7 PMNs pmn NNS cord-015021-pol2qm74 3190 8 , , , cord-015021-pol2qm74 3190 9 which which WDT cord-015021-pol2qm74 3190 10 are be VBP cord-015021-pol2qm74 3190 11 excessively excessively RB cord-015021-pol2qm74 3190 12 activated activate VBN cord-015021-pol2qm74 3190 13 by by IN cord-015021-pol2qm74 3190 14 G G NNP cord-015021-pol2qm74 3190 15 - - HYPH cord-015021-pol2qm74 3190 16 CSF CSF NNP cord-015021-pol2qm74 3190 17 and and CC cord-015021-pol2qm74 3190 18 IL-8 IL-8 NNP cord-015021-pol2qm74 3190 19 , , , cord-015021-pol2qm74 3190 20 may may MD cord-015021-pol2qm74 3190 21 adhere adhere VB cord-015021-pol2qm74 3190 22 to to IN cord-015021-pol2qm74 3190 23 the the DT cord-015021-pol2qm74 3190 24 endotherial endotherial JJ cord-015021-pol2qm74 3190 25 cells cell NNS cord-015021-pol2qm74 3190 26 and and CC cord-015021-pol2qm74 3190 27 then then RB cord-015021-pol2qm74 3190 28 migrate migrate VB cord-015021-pol2qm74 3190 29 into into IN cord-015021-pol2qm74 3190 30 the the DT cord-015021-pol2qm74 3190 31 tissues tissue NNS cord-015021-pol2qm74 3190 32 , , , cord-015021-pol2qm74 3190 33 and and CC cord-015021-pol2qm74 3190 34 cause cause VB cord-015021-pol2qm74 3190 35 multiple multiple JJ cord-015021-pol2qm74 3190 36 organ organ NN cord-015021-pol2qm74 3190 37 damage damage NN cord-015021-pol2qm74 3190 38 after after IN cord-015021-pol2qm74 3190 39 surgery surgery NN cord-015021-pol2qm74 3190 40 for for IN cord-015021-pol2qm74 3190 41 esophageal esophageal JJ cord-015021-pol2qm74 3190 42 cancer cancer NN cord-015021-pol2qm74 3190 43 . . . cord-015021-pol2qm74 3191 1 ImmunNogical ImmunNogical NNP cord-015021-pol2qm74 3191 2 changes change NNS cord-015021-pol2qm74 3191 3 in in IN cord-015021-pol2qm74 3191 4 patients patient NNS cord-015021-pol2qm74 3191 5 with with IN cord-015021-pol2qm74 3191 6 severe severe JJ cord-015021-pol2qm74 3191 7 brain brain NN cord-015021-pol2qm74 3191 8 trauma trauma NN cord-015021-pol2qm74 3191 9 receive receive VBP cord-015021-pol2qm74 3191 10 increasing increase VBG cord-015021-pol2qm74 3191 11 attention attention NN cord-015021-pol2qm74 3191 12 since since IN cord-015021-pol2qm74 3191 13 morbidity morbidity NN cord-015021-pol2qm74 3191 14 and and CC cord-015021-pol2qm74 3191 15 mortality mortality NN cord-015021-pol2qm74 3191 16 ere ere VBP cord-015021-pol2qm74 3191 17 still still RB cord-015021-pol2qm74 3191 18 high high JJ cord-015021-pol2qm74 3191 19 . . . cord-015021-pol2qm74 3192 1 Interleukin-6 Interleukin-6 NNP cord-015021-pol2qm74 3193 1 ( ( -LRB- cord-015021-pol2qm74 3193 2 IL-6 IL-6 NNP cord-015021-pol2qm74 3193 3 ) ) -RRB- cord-015021-pol2qm74 3193 4 was be VBD cord-015021-pol2qm74 3193 5 previously previously RB cord-015021-pol2qm74 3193 6 detected detect VBN cord-015021-pol2qm74 3193 7 in in IN cord-015021-pol2qm74 3193 8 the the DT cord-015021-pol2qm74 3193 9 cerebrospinal cerebrospinal JJ cord-015021-pol2qm74 3193 10 fluid fluid NN cord-015021-pol2qm74 3193 11 ( ( -LRB- cord-015021-pol2qm74 3193 12 CSF CSF NNP cord-015021-pol2qm74 3193 13 ) ) -RRB- cord-015021-pol2qm74 3193 14 during during IN cord-015021-pol2qm74 3193 15 different different JJ cord-015021-pol2qm74 3193 16 pathologies pathology NNS cord-015021-pol2qm74 3193 17 of of IN cord-015021-pol2qm74 3193 18 the the DT cord-015021-pol2qm74 3193 19 nervous nervous JJ cord-015021-pol2qm74 3193 20 system system NN cord-015021-pol2qm74 3193 21 ( ( -LRB- cord-015021-pol2qm74 3193 22 1 1 CD cord-015021-pol2qm74 3193 23 , , , cord-015021-pol2qm74 3193 24 2 2 CD cord-015021-pol2qm74 3193 25 , , , cord-015021-pol2qm74 3193 26 3 3 CD cord-015021-pol2qm74 3193 27 ) ) -RRB- cord-015021-pol2qm74 3193 28 . . . cord-015021-pol2qm74 3194 1 in in IN cord-015021-pol2qm74 3194 2 our -PRON- PRP$ cord-015021-pol2qm74 3194 3 study study NN cord-015021-pol2qm74 3194 4 we -PRON- PRP cord-015021-pol2qm74 3194 5 monitored monitor VBD cord-015021-pol2qm74 3194 6 iL-6 il-6 DT cord-015021-pol2qm74 3194 7 and and CC cord-015021-pol2qm74 3194 8 Nerve Nerve NNP cord-015021-pol2qm74 3194 9 Growth Growth NNP cord-015021-pol2qm74 3194 10 Factor factor NN cord-015021-pol2qm74 3194 11 ( ( -LRB- cord-015021-pol2qm74 3194 12 NGF NGF NNP cord-015021-pol2qm74 3194 13 ) ) -RRB- cord-015021-pol2qm74 3194 14 production production NN cord-015021-pol2qm74 3194 15 in in IN cord-015021-pol2qm74 3194 16 the the DT cord-015021-pol2qm74 3194 17 CSF CSF NNP cord-015021-pol2qm74 3194 18 after after IN cord-015021-pol2qm74 3194 19 human human JJ cord-015021-pol2qm74 3194 20 brain brain NN cord-015021-pol2qm74 3194 21 trauma trauma NN cord-015021-pol2qm74 3194 22 . . . cord-015021-pol2qm74 3195 1 Since since IN cord-015021-pol2qm74 3195 2 astrocytes astrocyte NNS cord-015021-pol2qm74 3195 3 within within IN cord-015021-pol2qm74 3195 4 the the DT cord-015021-pol2qm74 3195 5 brain brain NN cord-015021-pol2qm74 3195 6 constitute constitute VBP cord-015021-pol2qm74 3195 7 one one CD cord-015021-pol2qm74 3195 8 of of IN cord-015021-pol2qm74 3195 9 the the DT cord-015021-pol2qm74 3195 10 major major JJ cord-015021-pol2qm74 3195 11 cell cell NN cord-015021-pol2qm74 3195 12 type type NN cord-015021-pol2qm74 3195 13 contributing contribute VBG cord-015021-pol2qm74 3195 14 to to IN cord-015021-pol2qm74 3195 15 the the DT cord-015021-pol2qm74 3195 16 inflammatory inflammatory JJ cord-015021-pol2qm74 3195 17 response response NN cord-015021-pol2qm74 3195 18 through through IN cord-015021-pol2qm74 3195 19 the the DT cord-015021-pol2qm74 3195 20 release release NN cord-015021-pol2qm74 3195 21 of of IN cord-015021-pol2qm74 3195 22 cytokines cytokine NNS cord-015021-pol2qm74 3195 23 and and CC cord-015021-pol2qm74 3195 24 other other JJ cord-015021-pol2qm74 3195 25 factors factor NNS cord-015021-pol2qm74 3195 26 after after IN cord-015021-pol2qm74 3195 27 injury injury NN cord-015021-pol2qm74 3195 28 , , , cord-015021-pol2qm74 3195 29 we -PRON- PRP cord-015021-pol2qm74 3195 30 investigated investigate VBD cord-015021-pol2qm74 3195 31 the the DT cord-015021-pol2qm74 3195 32 functional functional JJ cord-015021-pol2qm74 3195 33 relationship relationship NN cord-015021-pol2qm74 3195 34 of of IN cord-015021-pol2qm74 3195 35 IL-6 IL-6 NNP cord-015021-pol2qm74 3195 36 and and CC cord-015021-pol2qm74 3195 37 NGF NGF NNP cord-015021-pol2qm74 3195 38 on on IN cord-015021-pol2qm74 3195 39 a a DT cord-015021-pol2qm74 3195 40 single single JJ cord-015021-pol2qm74 3195 41 cell cell NN cord-015021-pol2qm74 3195 42 niveau niveau NN cord-015021-pol2qm74 3195 43 using use VBG cord-015021-pol2qm74 3195 44 cultured cultured JJ cord-015021-pol2qm74 3195 45 astrocytes astrocyte NNS cord-015021-pol2qm74 3195 46 . . . cord-015021-pol2qm74 3196 1 Methods Methods NNPS cord-015021-pol2qm74 3196 2 CSF CSF NNP cord-015021-pol2qm74 3196 3 was be VBD cord-015021-pol2qm74 3196 4 obtained obtain VBN cord-015021-pol2qm74 3196 5 from from IN cord-015021-pol2qm74 3196 6 patients patient NNS cord-015021-pol2qm74 3196 7 with with IN cord-015021-pol2qm74 3196 8 severe severe JJ cord-015021-pol2qm74 3196 9 brain brain NN cord-015021-pol2qm74 3196 10 injury injury NN cord-015021-pol2qm74 3197 1 ( ( -LRB- cord-015021-pol2qm74 3197 2 Glasgow Glasgow NNP cord-015021-pol2qm74 3197 3 Coma Coma NNP cord-015021-pol2qm74 3197 4 Score Score NNP cord-015021-pol2qm74 3197 5 ( ( -LRB- cord-015021-pol2qm74 3197 6 GCS GCS NNP cord-015021-pol2qm74 3197 7 ) ) -RRB- cord-015021-pol2qm74 3198 1 < < NNP cord-015021-pol2qm74 3198 2 8 8 CD cord-015021-pol2qm74 3198 3 and and CC cord-015021-pol2qm74 3198 4 CT CT NNP cord-015021-pol2qm74 3198 5 abnormatities abnormatitie NNS cord-015021-pol2qm74 3198 6 or or CC cord-015021-pol2qm74 3199 1 GCS GCS NNP cord-015021-pol2qm74 3199 2 < < XX cord-015021-pol2qm74 3199 3 8 8 CD cord-015021-pol2qm74 3199 4 over over IN cord-015021-pol2qm74 3199 5 6 6 CD cord-015021-pol2qm74 3199 6 hours hour NNS cord-015021-pol2qm74 3199 7 ) ) -RRB- cord-015021-pol2qm74 3200 1 after after IN cord-015021-pol2qm74 3200 2 implantation implantation NN cord-015021-pol2qm74 3200 3 of of IN cord-015021-pol2qm74 3200 4 intraventricular intraventricular JJ cord-015021-pol2qm74 3200 5 ICP ICP NNP cord-015021-pol2qm74 3200 6 monitoring monitor VBG cord-015021-pol2qm74 3200 7 device device NN cord-015021-pol2qm74 3200 8 for for IN cord-015021-pol2qm74 3200 9 therapeutic therapeutic JJ cord-015021-pol2qm74 3200 10 purpose purpose NN cord-015021-pol2qm74 3200 11 and and CC cord-015021-pol2qm74 3200 12 collected collect VBD cord-015021-pol2qm74 3200 13 over over IN cord-015021-pol2qm74 3200 14 24 24 CD cord-015021-pol2qm74 3200 15 hours hour NNS cord-015021-pol2qm74 3200 16 CSF csf NN cord-015021-pol2qm74 3200 17 and and CC cord-015021-pol2qm74 3200 18 serum serum NN cord-015021-pol2qm74 3200 19 . . . cord-015021-pol2qm74 3201 1 IL-6 IL-6 NNP cord-015021-pol2qm74 3201 2 and and CC cord-015021-pol2qm74 3201 3 NGF NGF NNP cord-015021-pol2qm74 3201 4 were be VBD cord-015021-pol2qm74 3201 5 assayed assay VBN cord-015021-pol2qm74 3201 6 by by IN cord-015021-pol2qm74 3201 7 ELISA ELISA NNP cord-015021-pol2qm74 3201 8 . . . cord-015021-pol2qm74 3202 1 Astrocytes Astrocytes NNP cord-015021-pol2qm74 3202 2 were be VBD cord-015021-pol2qm74 3202 3 isolated isolate VBN cord-015021-pol2qm74 3202 4 from from IN cord-015021-pol2qm74 3202 5 neonatal neonatal JJ cord-015021-pol2qm74 3202 6 mouse mouse NN cord-015021-pol2qm74 3202 7 brain brain NN cord-015021-pol2qm74 3202 8 as as IN cord-015021-pol2qm74 3202 9 described describe VBN cord-015021-pol2qm74 3202 10 ( ( -LRB- cord-015021-pol2qm74 3202 11 4 4 CD cord-015021-pol2qm74 3202 12 ) ) -RRB- cord-015021-pol2qm74 3202 13 . . . cord-015021-pol2qm74 3203 1 NGF NGF NNP cord-015021-pol2qm74 3203 2 production production NN cord-015021-pol2qm74 3203 3 by by IN cord-015021-pol2qm74 3203 4 cultured cultured JJ cord-015021-pol2qm74 3203 5 astrocytes astrocyte NNS cord-015021-pol2qm74 3203 6 was be VBD cord-015021-pol2qm74 3203 7 measured measure VBN cord-015021-pol2qm74 3203 8 by by IN cord-015021-pol2qm74 3203 9 ELISA ELISA NNP cord-015021-pol2qm74 3203 10 in in IN cord-015021-pol2qm74 3203 11 the the DT cord-015021-pol2qm74 3203 12 presence presence NN cord-015021-pol2qm74 3203 13 of of IN cord-015021-pol2qm74 3203 14 CSF CSF NNP cord-015021-pol2qm74 3203 15 , , , cord-015021-pol2qm74 3203 16 IL-6 IL-6 NNP cord-015021-pol2qm74 3203 17 and and CC cord-015021-pol2qm74 3203 18 IL-6 IL-6 NNP cord-015021-pol2qm74 3203 19 antibody antibody NN cord-015021-pol2qm74 3203 20 . . . cord-015021-pol2qm74 3204 1 Astrocyte Astrocyte NNP cord-015021-pol2qm74 3204 2 migration migration NN cord-015021-pol2qm74 3204 3 was be VBD cord-015021-pol2qm74 3204 4 tested test VBN cord-015021-pol2qm74 3204 5 in in IN cord-015021-pol2qm74 3204 6 a a DT cord-015021-pol2qm74 3204 7 chemstaxis chemstaxis NNP cord-015021-pol2qm74 3204 8 chamber chamber NN cord-015021-pol2qm74 3204 9 . . . cord-015021-pol2qm74 3205 1 Results result NNS cord-015021-pol2qm74 3206 1 17 17 CD cord-015021-pol2qm74 3206 2 head head NN cord-015021-pol2qm74 3206 3 trauma trauma NN cord-015021-pol2qm74 3206 4 patients patient NNS cord-015021-pol2qm74 3206 5 were be VBD cord-015021-pol2qm74 3206 6 included include VBN cord-015021-pol2qm74 3206 7 in in IN cord-015021-pol2qm74 3206 8 this this DT cord-015021-pol2qm74 3206 9 study study NN cord-015021-pol2qm74 3206 10 ( ( -LRB- cord-015021-pol2qm74 3206 11 approved approve VBN cord-015021-pol2qm74 3206 12 by by IN cord-015021-pol2qm74 3206 13 the the DT cord-015021-pol2qm74 3206 14 University University NNP cord-015021-pol2qm74 3206 15 Hospital Hospital NNP cord-015021-pol2qm74 3206 16 Medical Medical NNP cord-015021-pol2qm74 3206 17 Ethics Ethics NNPS cord-015021-pol2qm74 3206 18 Board Board NNP cord-015021-pol2qm74 3206 19 ) ) -RRB- cord-015021-pol2qm74 3206 20 and and CC cord-015021-pol2qm74 3206 21 the the DT cord-015021-pol2qm74 3206 22 CSF CSF NNP cord-015021-pol2qm74 3206 23 was be VBD cord-015021-pol2qm74 3206 24 obtained obtain VBN cord-015021-pol2qm74 3206 25 through through IN cord-015021-pol2qm74 3206 26 intraventricular intraventricular JJ cord-015021-pol2qm74 3206 27 catheters catheter NNS cord-015021-pol2qm74 3206 28 . . . cord-015021-pol2qm74 3207 1 High high JJ cord-015021-pol2qm74 3207 2 levels level NNS cord-015021-pol2qm74 3207 3 of of IN cord-015021-pol2qm74 3207 4 IL-6 IL-6 NNP cord-015021-pol2qm74 3207 5 were be VBD cord-015021-pol2qm74 3207 6 detected detect VBN cord-015021-pol2qm74 3207 7 in in IN cord-015021-pol2qm74 3207 8 the the DT cord-015021-pol2qm74 3207 9 CSF csf NN cord-015021-pol2qm74 3207 10 of of IN cord-015021-pol2qm74 3207 11 these these DT cord-015021-pol2qm74 3207 12 patients patient NNS cord-015021-pol2qm74 3207 13 when when WRB cord-015021-pol2qm74 3207 14 compared compare VBN cord-015021-pol2qm74 3207 15 to to IN cord-015021-pol2qm74 3207 16 serum serum NN cord-015021-pol2qm74 3207 17 during during IN cord-015021-pol2qm74 3207 18 the the DT cord-015021-pol2qm74 3207 19 first first JJ cord-015021-pol2qm74 3207 20 days day NNS cord-015021-pol2qm74 3207 21 after after IN cord-015021-pol2qm74 3207 22 brain brain NN cord-015021-pol2qm74 3207 23 trauma trauma NN cord-015021-pol2qm74 3207 24 . . . cord-015021-pol2qm74 3208 1 Furthermore furthermore RB cord-015021-pol2qm74 3208 2 NGF NGF NNP cord-015021-pol2qm74 3208 3 could could MD cord-015021-pol2qm74 3208 4 be be VB cord-015021-pol2qm74 3208 5 found find VBN cord-015021-pol2qm74 3208 6 inside inside IN cord-015021-pol2qm74 3208 7 the the DT cord-015021-pol2qm74 3208 8 intracerebral intracerebral NNP cord-015021-pol2qm74 3208 9 compartment compartment NNP cord-015021-pol2qm74 3208 10 . . . cord-015021-pol2qm74 3209 1 CSF csf NN cord-015021-pol2qm74 3209 2 containing contain VBG cord-015021-pol2qm74 3209 3 high high JJ cord-015021-pol2qm74 3209 4 levels level NNS cord-015021-pol2qm74 3209 5 of of IN cord-015021-pol2qm74 3209 6 IL-6 IL-6 NNP cord-015021-pol2qm74 3209 7 could could MD cord-015021-pol2qm74 3209 8 stimulate stimulate VB cord-015021-pol2qm74 3209 9 NGF NGF NNP cord-015021-pol2qm74 3209 10 production production NN cord-015021-pol2qm74 3209 11 in in IN cord-015021-pol2qm74 3209 12 cultured cultured JJ cord-015021-pol2qm74 3209 13 astrocytes astrocyte NNS cord-015021-pol2qm74 3209 14 . . . cord-015021-pol2qm74 3210 1 This this DT cord-015021-pol2qm74 3210 2 effect effect NN cord-015021-pol2qm74 3210 3 could could MD cord-015021-pol2qm74 3210 4 be be VB cord-015021-pol2qm74 3210 5 [ [ -LRB- cord-015021-pol2qm74 3210 6 nhibited nhibite VBN cord-015021-pol2qm74 3210 7 partially partially RB cord-015021-pol2qm74 3210 8 by by IN cord-015021-pol2qm74 3210 9 IL-6 IL-6 NNP cord-015021-pol2qm74 3210 10 antibodies antibody NNS cord-015021-pol2qm74 3210 11 , , , cord-015021-pol2qm74 3210 12 Purified purify VBN cord-015021-pol2qm74 3210 13 IL-6 IL-6 NNP cord-015021-pol2qm74 3210 14 exposed expose VBN cord-015021-pol2qm74 3210 15 to to IN cord-015021-pol2qm74 3210 16 cultured cultured JJ cord-015021-pol2qm74 3210 17 astrocytes astrocyte NNS cord-015021-pol2qm74 3210 18 in in IN cord-015021-pol2qm74 3210 19 vitro vitro FW cord-015021-pol2qm74 3210 20 , , , cord-015021-pol2qm74 3210 21 stimulated stimulate VBD cord-015021-pol2qm74 3210 22 the the DT cord-015021-pol2qm74 3210 23 migratory migratory JJ cord-015021-pol2qm74 3210 24 activity activity NN cord-015021-pol2qm74 3210 25 of of IN cord-015021-pol2qm74 3210 26 these these DT cord-015021-pol2qm74 3210 27 cells cell NNS cord-015021-pol2qm74 3210 28 in in IN cord-015021-pol2qm74 3210 29 a a DT cord-015021-pol2qm74 3210 30 dose dose JJ cord-015021-pol2qm74 3210 31 response response NN cord-015021-pol2qm74 3210 32 fashion fashion NN cord-015021-pol2qm74 3210 33 . . . cord-015021-pol2qm74 3211 1 IL-6 IL-6 NNP cord-015021-pol2qm74 3211 2 was be VBD cord-015021-pol2qm74 3211 3 found find VBN cord-015021-pol2qm74 3211 4 in in IN cord-015021-pol2qm74 3211 5 the the DT cord-015021-pol2qm74 3211 6 CSF CSF NNP cord-015021-pol2qm74 3211 7 of of IN cord-015021-pol2qm74 3211 8 brain brain NN cord-015021-pol2qm74 3211 9 injured injure VBN cord-015021-pol2qm74 3211 10 patients patient NNS cord-015021-pol2qm74 3211 11 , , , cord-015021-pol2qm74 3211 12 suggesting suggest VBG cord-015021-pol2qm74 3211 13 a a DT cord-015021-pol2qm74 3211 14 role role NN cord-015021-pol2qm74 3211 15 for for IN cord-015021-pol2qm74 3211 16 this this DT cord-015021-pol2qm74 3211 17 cytokine cytokine NN cord-015021-pol2qm74 3211 18 in in IN cord-015021-pol2qm74 3211 19 the the DT cord-015021-pol2qm74 3211 20 pathophysiology pathophysiology NN cord-015021-pol2qm74 3211 21 of of IN cord-015021-pol2qm74 3211 22 brain brain NN cord-015021-pol2qm74 3211 23 injury injury NN cord-015021-pol2qm74 3211 24 . . . cord-015021-pol2qm74 3212 1 Since since IN cord-015021-pol2qm74 3212 2 astrocytes astrocyte NNS cord-015021-pol2qm74 3212 3 are be VBP cord-015021-pol2qm74 3212 4 involved involve VBN cord-015021-pol2qm74 3212 5 in in IN cord-015021-pol2qm74 3212 6 maintaining maintain VBG cord-015021-pol2qm74 3212 7 the the DT cord-015021-pol2qm74 3212 8 homeostasis homeostasis NN cord-015021-pol2qm74 3212 9 of of IN cord-015021-pol2qm74 3212 10 the the DT cord-015021-pol2qm74 3212 11 brain brain NN cord-015021-pol2qm74 3212 12 , , , cord-015021-pol2qm74 3212 13 we -PRON- PRP cord-015021-pol2qm74 3212 14 further further RB cord-015021-pol2qm74 3212 15 investigated investigate VBD cord-015021-pol2qm74 3212 16 the the DT cord-015021-pol2qm74 3212 17 possible possible JJ cord-015021-pol2qm74 3212 18 role role NN cord-015021-pol2qm74 3212 19 o1 o1 NNP cord-015021-pol2qm74 3212 20 IL-6 IL-6 NNP cord-015021-pol2qm74 3212 21 on on IN cord-015021-pol2qm74 3212 22 astrocyte astrocyte NNP cord-015021-pol2qm74 3212 23 functions function NNS cord-015021-pol2qm74 3212 24 , , , cord-015021-pol2qm74 3212 25 IL-6 IL-6 NNP cord-015021-pol2qm74 3212 26 promoted promote VBD cord-015021-pol2qm74 3212 27 NGF NGF NNP cord-015021-pol2qm74 3212 28 production production NN cord-015021-pol2qm74 3212 29 in in IN cord-015021-pol2qm74 3212 30 vivo vivo NN cord-015021-pol2qm74 3212 31 and and CC cord-015021-pol2qm74 3212 32 in in IN cord-015021-pol2qm74 3212 33 vitro vitro FW cord-015021-pol2qm74 3212 34 , , , cord-015021-pol2qm74 3212 35 thus thus RB cord-015021-pol2qm74 3212 36 contributing contribute VBG cord-015021-pol2qm74 3212 37 to to IN cord-015021-pol2qm74 3212 38 neuronal neuronal JJ cord-015021-pol2qm74 3212 39 cell cell NN cord-015021-pol2qm74 3212 40 survival survival NN cord-015021-pol2qm74 3212 41 and and CC cord-015021-pol2qm74 3212 42 regeneration regeneration NN cord-015021-pol2qm74 3212 43 . . . cord-015021-pol2qm74 3213 1 Furthermore furthermore RB cord-015021-pol2qm74 3213 2 IL-6 IL-6 NNP cord-015021-pol2qm74 3213 3 stimulated stimulate VBD cord-015021-pol2qm74 3213 4 astrocyte astrocyte NNP cord-015021-pol2qm74 3213 5 migration migration NN cord-015021-pol2qm74 3213 6 in in IN cord-015021-pol2qm74 3213 7 a a DT cord-015021-pol2qm74 3213 8 dose dose JJ cord-015021-pol2qm74 3213 9 response response NN cord-015021-pol2qm74 3213 10 fashion fashion NN cord-015021-pol2qm74 3213 11 , , , cord-015021-pol2qm74 3213 12 potentially potentially RB cord-015021-pol2qm74 3213 13 contributing contribute VBG cord-015021-pol2qm74 3213 14 to to IN cord-015021-pol2qm74 3213 15 astrocytosis astrocytosis NN cord-015021-pol2qm74 3213 16 following follow VBG cord-015021-pol2qm74 3213 17 brain brain NN cord-015021-pol2qm74 3213 18 injury injury NN cord-015021-pol2qm74 3213 19 and and CC cord-015021-pol2qm74 3213 20 inflammation inflammation NN cord-015021-pol2qm74 3213 21 , , , cord-015021-pol2qm74 3213 22 These these DT cord-015021-pol2qm74 3213 23 results result NNS cord-015021-pol2qm74 3213 24 show show VBP cord-015021-pol2qm74 3213 25 that that IN cord-015021-pol2qm74 3213 26 IL-6 IL-6 NNP cord-015021-pol2qm74 3213 27 represents represent VBZ cord-015021-pol2qm74 3213 28 a a DT cord-015021-pol2qm74 3213 29 key key JJ cord-015021-pol2qm74 3213 30 cytokine cytokine NN cord-015021-pol2qm74 3213 31 in in IN cord-015021-pol2qm74 3213 32 traumatic traumatic JJ cord-015021-pol2qm74 3213 33 human human JJ cord-015021-pol2qm74 3213 34 brain brain NN cord-015021-pol2qm74 3213 35 injury injury NN cord-015021-pol2qm74 3213 36 with with IN cord-015021-pol2qm74 3213 37 possible possible JJ cord-015021-pol2qm74 3213 38 systemic systemic JJ cord-015021-pol2qm74 3213 39 effects effect NNS cord-015021-pol2qm74 3213 40 , , , cord-015021-pol2qm74 3213 41 which which WDT cord-015021-pol2qm74 3213 42 are be VBP cord-015021-pol2qm74 3213 43 at at IN cord-015021-pol2qm74 3213 44 preserlt preserlt NNP cord-015021-pol2qm74 3213 45 under under IN cord-015021-pol2qm74 3213 46 investigation investigation NN cord-015021-pol2qm74 3213 47 . . . cord-015021-pol2qm74 3214 1 We -PRON- PRP cord-015021-pol2qm74 3214 2 studied study VBD cord-015021-pol2qm74 3214 3 a a DT cord-015021-pol2qm74 3214 4 ) ) -RRB- cord-015021-pol2qm74 3214 5 the the DT cord-015021-pol2qm74 3214 6 role role NN cord-015021-pol2qm74 3214 7 of of IN cord-015021-pol2qm74 3214 8 TNF TNF NNP cord-015021-pol2qm74 3214 9 and and CC cord-015021-pol2qm74 3214 10 b b LS cord-015021-pol2qm74 3214 11 ) ) -RRB- cord-015021-pol2qm74 3214 12 the the DT cord-015021-pol2qm74 3214 13 therapeutic therapeutic JJ cord-015021-pol2qm74 3214 14 effect effect NN cord-015021-pol2qm74 3214 15 of of IN cord-015021-pol2qm74 3214 16 a a DT cord-015021-pol2qm74 3214 17 mab mab NN cord-015021-pol2qm74 3214 18 to to IN cord-015021-pol2qm74 3214 19 TNF TNF NNP cord-015021-pol2qm74 3214 20 with with IN cord-015021-pol2qm74 3214 21 regard regard NN cord-015021-pol2qm74 3214 22 to to IN cord-015021-pol2qm74 3214 23 haemorrhagic haemorrhagic JJ cord-015021-pol2qm74 3214 24 shock shock NN cord-015021-pol2qm74 3214 25 ( ( -LRB- cord-015021-pol2qm74 3214 26 HS HS NNP cord-015021-pol2qm74 3214 27 ) ) -RRB- cord-015021-pol2qm74 3214 28 related relate VBN cord-015021-pol2qm74 3214 29 , , , cord-015021-pol2qm74 3214 30 pathophysiologic pathophysiologic JJ cord-015021-pol2qm74 3214 31 alterations alteration NNS cord-015021-pol2qm74 3214 32 and and CC cord-015021-pol2qm74 3214 33 mortality mortality NN cord-015021-pol2qm74 3214 34 in in IN cord-015021-pol2qm74 3214 35 rats rat NNS cord-015021-pol2qm74 3214 36 . . . cord-015021-pol2qm74 3215 1 Method method NN cord-015021-pol2qm74 3215 2 : : : cord-015021-pol2qm74 3216 1 A a DT cord-015021-pol2qm74 3216 2 prolonged prolonged JJ cord-015021-pol2qm74 3216 3 HS hs NN cord-015021-pol2qm74 3216 4 was be VBD cord-015021-pol2qm74 3216 5 induced induce VBN cord-015021-pol2qm74 3216 6 by by IN cord-015021-pol2qm74 3216 7 bleeding bleed VBG cord-015021-pol2qm74 3216 8 to to IN cord-015021-pol2qm74 3216 9 a a DT cord-015021-pol2qm74 3216 10 blood blood NN cord-015021-pol2qm74 3216 11 pressure pressure NN cord-015021-pol2qm74 3216 12 of of IN cord-015021-pol2qm74 3216 13 30 30 CD cord-015021-pol2qm74 3216 14 - - SYM cord-015021-pol2qm74 3216 15 35 35 CD cord-015021-pol2qm74 3216 16 mmHg mmHg NNS cord-015021-pol2qm74 3216 17 for for IN cord-015021-pol2qm74 3216 18 180 180 CD cord-015021-pol2qm74 3216 19 pin pin NN cord-015021-pol2qm74 3216 20 followed follow VBN cord-015021-pol2qm74 3216 21 by by IN cord-015021-pol2qm74 3216 22 reinfusion reinfusion NN cord-015021-pol2qm74 3216 23 of of IN cord-015021-pol2qm74 3216 24 shed shed JJ cord-015021-pol2qm74 3216 25 blood blood NN cord-015021-pol2qm74 3216 26 ( ( -LRB- cord-015021-pol2qm74 3216 27 SB SB NNP cord-015021-pol2qm74 3216 28 ) ) -RRB- cord-015021-pol2qm74 3216 29 and and CC cord-015021-pol2qm74 3216 30 resuscitation resuscitation NN cord-015021-pol2qm74 3216 31 with with IN cord-015021-pol2qm74 3216 32 two two CD cord-015021-pol2qm74 3216 33 times time NNS cord-015021-pol2qm74 3216 34 of of IN cord-015021-pol2qm74 3216 35 SB SB NNP cord-015021-pol2qm74 3216 36 volume volume NN cord-015021-pol2qm74 3216 37 of of IN cord-015021-pol2qm74 3216 38 Ringer Ringer NNP cord-015021-pol2qm74 3216 39 's 's POS cord-015021-pol2qm74 3216 40 lactate lactate NN cord-015021-pol2qm74 3216 41 over over IN cord-015021-pol2qm74 3216 42 50 50 CD cord-015021-pol2qm74 3216 43 rain rain NN cord-015021-pol2qm74 3216 44 . . . cord-015021-pol2qm74 3217 1 15 15 CD cord-015021-pol2qm74 3217 2 animals animal NNS cord-015021-pol2qm74 3217 3 received receive VBD cord-015021-pol2qm74 3217 4 a a DT cord-015021-pol2qm74 3217 5 bolus bolus NN cord-015021-pol2qm74 3217 6 dose dose NN cord-015021-pol2qm74 3217 7 ( ( -LRB- cord-015021-pol2qm74 3217 8 20 20 CD cord-015021-pol2qm74 3217 9 mg mg NNP cord-015021-pol2qm74 3217 10 / / SYM cord-015021-pol2qm74 3217 11 kg kg NNP cord-015021-pol2qm74 3217 12 ) ) -RRB- cord-015021-pol2qm74 3217 13 of of IN cord-015021-pol2qm74 3217 14 TNF TNF NNP cord-015021-pol2qm74 3217 15 mab mab NNP cord-015021-pol2qm74 3217 16 ( ( -LRB- cord-015021-pol2qm74 3217 17 Celltech Celltech NNP cord-015021-pol2qm74 3217 18 , , , cord-015021-pol2qm74 3217 19 Berkshire Berkshire NNP cord-015021-pol2qm74 3217 20 , , , cord-015021-pol2qm74 3217 21 UK UK NNP cord-015021-pol2qm74 3217 22 ) ) -RRB- cord-015021-pol2qm74 3217 23 at at IN cord-015021-pol2qm74 3217 24 15 15 CD cord-015021-pol2qm74 3217 25 min min NN cord-015021-pol2qm74 3217 26 after after IN cord-015021-pol2qm74 3217 27 resuscitation resuscitation NN cord-015021-pol2qm74 3217 28 ( ( -LRB- cord-015021-pol2qm74 3217 29 TN3 TN3 NNP cord-015021-pol2qm74 3217 30 ) ) -RRB- cord-015021-pol2qm74 3217 31 . . . cord-015021-pol2qm74 3218 1 The the DT cord-015021-pol2qm74 3218 2 control control NN cord-015021-pol2qm74 3218 3 group group NN cord-015021-pol2qm74 3218 4 ( ( -LRB- cord-015021-pol2qm74 3218 5 n n NN cord-015021-pol2qm74 3218 6 = = SYM cord-015021-pol2qm74 3218 7 15 15 CD cord-015021-pol2qm74 3218 8 ) ) -RRB- cord-015021-pol2qm74 3218 9 was be VBD cord-015021-pol2qm74 3218 10 treated treat VBN cord-015021-pol2qm74 3218 11 similar similar JJ cord-015021-pol2qm74 3218 12 to to IN cord-015021-pol2qm74 3218 13 the the DT cord-015021-pol2qm74 3218 14 TN3 TN3 NNP cord-015021-pol2qm74 3218 15 group group NN cord-015021-pol2qm74 3218 16 but but CC cord-015021-pol2qm74 3218 17 received receive VBD cord-015021-pol2qm74 3218 18 Ringer Ringer NNP cord-015021-pol2qm74 3218 19 's 's POS cord-015021-pol2qm74 3218 20 lactate lactate NN cord-015021-pol2qm74 3218 21 ( ( -LRB- cord-015021-pol2qm74 3218 22 CON con NN cord-015021-pol2qm74 3218 23 ) ) -RRB- cord-015021-pol2qm74 3218 24 . . . cord-015021-pol2qm74 3219 1 Results result NNS cord-015021-pol2qm74 3219 2 : : : cord-015021-pol2qm74 3220 1 At at IN cord-015021-pol2qm74 3220 2 180 180 CD cord-015021-pol2qm74 3220 3 min min NN cord-015021-pol2qm74 3220 4 the the DT cord-015021-pol2qm74 3220 5 prolonged prolonged JJ cord-015021-pol2qm74 3220 6 HS HS NNP cord-015021-pol2qm74 3220 7 resulted result VBD cord-015021-pol2qm74 3220 8 in in IN cord-015021-pol2qm74 3220 9 a a DT cord-015021-pol2qm74 3220 10 metabolic metabolic JJ cord-015021-pol2qm74 3220 11 acidosis acidosis NN cord-015021-pol2qm74 3220 12 indicated indicate VBN cord-015021-pol2qm74 3220 13 by by IN cord-015021-pol2qm74 3220 14 a a DT cord-015021-pol2qm74 3220 15 significant significant JJ cord-015021-pol2qm74 3220 16 decrease decrease NN cord-015021-pol2qm74 3220 17 of of IN cord-015021-pol2qm74 3220 18 blood blood NN cord-015021-pol2qm74 3220 19 pH ph NN cord-015021-pol2qm74 3220 20 ( ( -LRB- cord-015021-pol2qm74 3220 21 7.16 7.16 CD cord-015021-pol2qm74 3220 22 + + SYM cord-015021-pol2qm74 3220 23 0.04 0.04 CD cord-015021-pol2qm74 3220 24 ) ) -RRB- cord-015021-pol2qm74 3220 25 , , . cord-015021-pol2qm74 3221 1 HCO3-(16.3 HCO3-(16.3 NNP cord-015021-pol2qm74 3221 2 _ _ NN cord-015021-pol2qm74 3221 3 _ _ NNP cord-015021-pol2qm74 3221 4 _ _ NN cord-015021-pol2qm74 3221 5 2.0 2.0 CD cord-015021-pol2qm74 3221 6 mM mm CD cord-015021-pol2qm74 3221 7 ) ) -RRB- cord-015021-pol2qm74 3221 8 , , , cord-015021-pol2qm74 3221 9 and and CC cord-015021-pol2qm74 3221 10 base base NN cord-015021-pol2qm74 3221 11 excess excess NN cord-015021-pol2qm74 3221 12 ( ( -LRB- cord-015021-pol2qm74 3221 13 -12.5 -12.5 CD cord-015021-pol2qm74 3221 14 + + SYM cord-015021-pol2qm74 3221 15 1.9 1.9 CD cord-015021-pol2qm74 3221 16 raM ram NN cord-015021-pol2qm74 3221 17 ) ) -RRB- cord-015021-pol2qm74 3221 18 values value NNS cord-015021-pol2qm74 3221 19 with with IN cord-015021-pol2qm74 3221 20 pCO2 pCO2 NNP cord-015021-pol2qm74 3221 21 ( ( -LRB- cord-015021-pol2qm74 3221 22 47.9 47.9 CD cord-015021-pol2qm74 3221 23 + + SYM cord-015021-pol2qm74 3221 24 7.7 7.7 CD cord-015021-pol2qm74 3221 25 mmHg mmHg NNPS cord-015021-pol2qm74 3221 26 ) ) -RRB- cord-015021-pol2qm74 3221 27 and and CC cord-015021-pol2qm74 3221 28 pO2 pO2 NNP cord-015021-pol2qm74 3221 29 ( ( -LRB- cord-015021-pol2qm74 3221 30 136.2 136.2 CD cord-015021-pol2qm74 3221 31 + + SYM cord-015021-pol2qm74 3221 32 20.1 20.1 CD cord-015021-pol2qm74 3221 33 mmHg mmHg NNS cord-015021-pol2qm74 3221 34 ) ) -RRB- cord-015021-pol2qm74 3221 35 in in IN cord-015021-pol2qm74 3221 36 the the DT cord-015021-pol2qm74 3221 37 TN3 tn3 NN cord-015021-pol2qm74 3221 38 with with IN cord-015021-pol2qm74 3221 39 no no DT cord-015021-pol2qm74 3221 40 difference difference NN cord-015021-pol2qm74 3221 41 to to IN cord-015021-pol2qm74 3221 42 the the DT cord-015021-pol2qm74 3221 43 CON con NN cord-015021-pol2qm74 3221 44 group group NN cord-015021-pol2qm74 3221 45 . . . cord-015021-pol2qm74 3222 1 Immediately immediately RB cord-015021-pol2qm74 3222 2 after after IN cord-015021-pol2qm74 3222 3 resuscitation resuscitation NN cord-015021-pol2qm74 3222 4 ( ( -LRB- cord-015021-pol2qm74 3222 5 230 230 CD cord-015021-pol2qm74 3222 6 min min NN cord-015021-pol2qm74 3222 7 ) ) -RRB- cord-015021-pol2qm74 3222 8 plasma plasma NN cord-015021-pol2qm74 3222 9 endotoxin endotoxin NN cord-015021-pol2qm74 3222 10 levels level NNS cord-015021-pol2qm74 3222 11 were be VBD cord-015021-pol2qm74 3222 12 found find VBN cord-015021-pol2qm74 3222 13 to to TO cord-015021-pol2qm74 3222 14 be be VB cord-015021-pol2qm74 3222 15 increased increase VBN cord-015021-pol2qm74 3222 16 in in IN cord-015021-pol2qm74 3222 17 both both DT cord-015021-pol2qm74 3222 18 groups group NNS cord-015021-pol2qm74 3222 19 ( ( -LRB- cord-015021-pol2qm74 3222 20 48.8 48.8 CD cord-015021-pol2qm74 3222 21 + + SYM cord-015021-pol2qm74 3222 22 73.3 73.3 CD cord-015021-pol2qm74 3222 23 in in IN cord-015021-pol2qm74 3222 24 TN3 TN3 NNP cord-015021-pol2qm74 3222 25 vs vs IN cord-015021-pol2qm74 3222 26 30.1 30.1 CD cord-015021-pol2qm74 3222 27 _ _ NNP cord-015021-pol2qm74 3222 28 25.7 25.7 CD cord-015021-pol2qm74 3222 29 pg pg NNP cord-015021-pol2qm74 3222 30 / / SYM cord-015021-pol2qm74 3222 31 ml ml NN cord-015021-pol2qm74 3222 32 in in IN cord-015021-pol2qm74 3222 33 CON con NN cord-015021-pol2qm74 3222 34 group group NN cord-015021-pol2qm74 3222 35 ) ) -RRB- cord-015021-pol2qm74 3222 36 . . . cord-015021-pol2qm74 3223 1 Prior prior RB cord-015021-pol2qm74 3223 2 to to IN cord-015021-pol2qm74 3223 3 the the DT cord-015021-pol2qm74 3223 4 treatment treatment NN cord-015021-pol2qm74 3223 5 with with IN cord-015021-pol2qm74 3223 6 TNF TNF NNP cord-015021-pol2qm74 3223 7 mab mab NNP cord-015021-pol2qm74 3223 8 ( ( -LRB- cord-015021-pol2qm74 3223 9 230 230 CD cord-015021-pol2qm74 3223 10 min min NN cord-015021-pol2qm74 3223 11 ) ) -RRB- cord-015021-pol2qm74 3223 12 there there EX cord-015021-pol2qm74 3223 13 was be VBD cord-015021-pol2qm74 3223 14 also also RB cord-015021-pol2qm74 3223 15 no no DT cord-015021-pol2qm74 3223 16 difference difference NN cord-015021-pol2qm74 3223 17 between between IN cord-015021-pol2qm74 3223 18 plasma plasma NN cord-015021-pol2qm74 3223 19 TNF TNF NNP cord-015021-pol2qm74 3223 20 levels level NNS cord-015021-pol2qm74 3223 21 of of IN cord-015021-pol2qm74 3223 22 the the DT cord-015021-pol2qm74 3223 23 two two CD cord-015021-pol2qm74 3223 24 groups group NNS cord-015021-pol2qm74 3223 25 ( ( -LRB- cord-015021-pol2qm74 3223 26 42.1 42.1 CD cord-015021-pol2qm74 3223 27 + + SYM cord-015021-pol2qm74 3223 28 60.7 60.7 CD cord-015021-pol2qm74 3223 29 in in IN cord-015021-pol2qm74 3223 30 TN3 TN3 NNP cord-015021-pol2qm74 3223 31 vs vs IN cord-015021-pol2qm74 3223 32 60 60 CD cord-015021-pol2qm74 3223 33 + + SYM cord-015021-pol2qm74 3223 34 141.8 141.8 CD cord-015021-pol2qm74 3223 35 pg pg NN cord-015021-pol2qm74 3223 36 / / SYM cord-015021-pol2qm74 3223 37 ml ml NN cord-015021-pol2qm74 3223 38 in in IN cord-015021-pol2qm74 3223 39 CON con NN cord-015021-pol2qm74 3223 40 group group NN cord-015021-pol2qm74 3223 41 ) ) -RRB- cord-015021-pol2qm74 3223 42 . . . cord-015021-pol2qm74 3224 1 Treatment treatment NN cord-015021-pol2qm74 3224 2 with with IN cord-015021-pol2qm74 3224 3 the the DT cord-015021-pol2qm74 3224 4 TNF TNF NNP cord-015021-pol2qm74 3224 5 mab mab NNP cord-015021-pol2qm74 3224 6 at at IN cord-015021-pol2qm74 3224 7 65 65 CD cord-015021-pol2qm74 3224 8 rain rain NN cord-015021-pol2qm74 3224 9 post post NN cord-015021-pol2qm74 3224 10 - - NN cord-015021-pol2qm74 3224 11 HS HS NNP cord-015021-pol2qm74 3224 12 improved improve VBD cord-015021-pol2qm74 3224 13 the the DT cord-015021-pol2qm74 3224 14 48hour 48hour JJ cord-015021-pol2qm74 3224 15 survival survival NN cord-015021-pol2qm74 3224 16 rate rate NN cord-015021-pol2qm74 3224 17 to to IN cord-015021-pol2qm74 3224 18 73.3 73.3 CD cord-015021-pol2qm74 3224 19 % % NN cord-015021-pol2qm74 3224 20 as as IN cord-015021-pol2qm74 3224 21 compared compare VBN cord-015021-pol2qm74 3224 22 to to IN cord-015021-pol2qm74 3224 23 26.7 26.7 CD cord-015021-pol2qm74 3224 24 % % NN cord-015021-pol2qm74 3224 25 in in IN cord-015021-pol2qm74 3224 26 the the DT cord-015021-pol2qm74 3224 27 control control NN cord-015021-pol2qm74 3224 28 group group NN cord-015021-pol2qm74 3224 29 . . . cord-015021-pol2qm74 3225 1 Macropathologic Macropathologic NNP cord-015021-pol2qm74 3225 2 evaluations evaluation NNS cord-015021-pol2qm74 3225 3 revealed reveal VBD cord-015021-pol2qm74 3225 4 frequency frequency NN cord-015021-pol2qm74 3225 5 of of IN cord-015021-pol2qm74 3225 6 intestinal intestinal JJ cord-015021-pol2qm74 3225 7 bleeding bleeding NN cord-015021-pol2qm74 3225 8 in in IN cord-015021-pol2qm74 3225 9 onIy oniy NN cord-015021-pol2qm74 3225 10 2 2 CD cord-015021-pol2qm74 3225 11 animals animal NNS cord-015021-pol2qm74 3225 12 in in IN cord-015021-pol2qm74 3225 13 the the DT cord-015021-pol2qm74 3225 14 TN3 TN3 NNP cord-015021-pol2qm74 3225 15 vs vs IN cord-015021-pol2qm74 3225 16 11 11 CD cord-015021-pol2qm74 3225 17 in in IN cord-015021-pol2qm74 3225 18 the the DT cord-015021-pol2qm74 3225 19 CON con NN cord-015021-pol2qm74 3225 20 group group NN cord-015021-pol2qm74 3225 21 . . . cord-015021-pol2qm74 3226 1 No no DT cord-015021-pol2qm74 3226 2 bleeding bleed VBG cord-015021-pol2qm74 3226 3 in in IN cord-015021-pol2qm74 3226 4 the the DT cord-015021-pol2qm74 3226 5 kidneys kidney NNS cord-015021-pol2qm74 3226 6 was be VBD cord-015021-pol2qm74 3226 7 found find VBN cord-015021-pol2qm74 3226 8 in in IN cord-015021-pol2qm74 3226 9 the the DT cord-015021-pol2qm74 3226 10 TN3 tn3 NN cord-015021-pol2qm74 3226 11 but but CC cord-015021-pol2qm74 3226 12 in in IN cord-015021-pol2qm74 3226 13 4 4 CD cord-015021-pol2qm74 3226 14 rats rat NNS cord-015021-pol2qm74 3226 15 in in IN cord-015021-pol2qm74 3226 16 the the DT cord-015021-pol2qm74 3226 17 CON con NN cord-015021-pol2qm74 3226 18 group group NN cord-015021-pol2qm74 3226 19 . . . cord-015021-pol2qm74 3227 1 The the DT cord-015021-pol2qm74 3227 2 significant significant JJ cord-015021-pol2qm74 3227 3 increase increase NN cord-015021-pol2qm74 3227 4 in in IN cord-015021-pol2qm74 3227 5 lung lung NN cord-015021-pol2qm74 3227 6 wet wet JJ cord-015021-pol2qm74 3227 7 weight weight NN cord-015021-pol2qm74 3227 8 observed observe VBD cord-015021-pol2qm74 3227 9 in in IN cord-015021-pol2qm74 3227 10 non non NNS cord-015021-pol2qm74 3227 11 - - NNS cord-015021-pol2qm74 3227 12 survivors survivor NNS cord-015021-pol2qm74 3227 13 in in IN cord-015021-pol2qm74 3227 14 the the DT cord-015021-pol2qm74 3227 15 CON con NN cord-015021-pol2qm74 3227 16 ( ( -LRB- cord-015021-pol2qm74 3227 17 n n NN cord-015021-pol2qm74 3227 18 = = SYM cord-015021-pol2qm74 3227 19 11 11 CD cord-015021-pol2qm74 3227 20 ) ) -RRB- cord-015021-pol2qm74 3227 21 was be VBD cord-015021-pol2qm74 3227 22 prevented prevent VBN cord-015021-pol2qm74 3227 23 in in IN cord-015021-pol2qm74 3227 24 animals animal NNS cord-015021-pol2qm74 3227 25 which which WDT cord-015021-pol2qm74 3227 26 died die VBD cord-015021-pol2qm74 3227 27 in in IN cord-015021-pol2qm74 3227 28 the the DT cord-015021-pol2qm74 3227 29 TN3 tn3 NN cord-015021-pol2qm74 3227 30 ( ( -LRB- cord-015021-pol2qm74 3227 31 n n NN cord-015021-pol2qm74 3227 32 = = SYM cord-015021-pol2qm74 3227 33 4 4 CD cord-015021-pol2qm74 3227 34 ) ) -RRB- cord-015021-pol2qm74 3227 35 group group NN cord-015021-pol2qm74 3227 36 ( ( -LRB- cord-015021-pol2qm74 3227 37 ( ( -LRB- cord-015021-pol2qm74 3227 38 9.3 9.3 CD cord-015021-pol2qm74 3227 39 + + CC cord-015021-pol2qm74 3227 40 _ _ NN cord-015021-pol2qm74 3227 41 2.4 2.4 CD cord-015021-pol2qm74 3227 42 vs vs IN cord-015021-pol2qm74 3227 43 6.3 6.3 CD cord-015021-pol2qm74 3227 44 + + CC cord-015021-pol2qm74 3227 45 _ _ NN cord-015021-pol2qm74 3227 46 1.0 1.0 CD cord-015021-pol2qm74 3227 47 g g NN cord-015021-pol2qm74 3227 48 / / SYM cord-015021-pol2qm74 3227 49 kg kg NNP cord-015021-pol2qm74 3227 50 ) ) -RRB- cord-015021-pol2qm74 3227 51 . . . cord-015021-pol2qm74 3228 1 Conclusion conclusion NN cord-015021-pol2qm74 3228 2 : : : cord-015021-pol2qm74 3229 1 Our -PRON- PRP$ cord-015021-pol2qm74 3229 2 data datum NNS cord-015021-pol2qm74 3229 3 suggest suggest VBP cord-015021-pol2qm74 3229 4 that that IN cord-015021-pol2qm74 3229 5 TNF TNF NNP cord-015021-pol2qm74 3229 6 formation formation NN cord-015021-pol2qm74 3229 7 induced induce VBN cord-015021-pol2qm74 3229 8 by by IN cord-015021-pol2qm74 3229 9 HS HS NNP cord-015021-pol2qm74 3229 10 in in IN cord-015021-pol2qm74 3229 11 rats rat NNS cord-015021-pol2qm74 3229 12 is be VBZ cord-015021-pol2qm74 3229 13 an an DT cord-015021-pol2qm74 3229 14 important important JJ cord-015021-pol2qm74 3229 15 mediator mediator NN cord-015021-pol2qm74 3229 16 for for IN cord-015021-pol2qm74 3229 17 pathophysiologic pathophysiologic JJ cord-015021-pol2qm74 3229 18 alterations alteration NNS cord-015021-pol2qm74 3229 19 leading lead VBG cord-015021-pol2qm74 3229 20 to to IN cord-015021-pol2qm74 3229 21 multi multi JJ cord-015021-pol2qm74 3229 22 organ organ NN cord-015021-pol2qm74 3229 23 failure failure NN cord-015021-pol2qm74 3229 24 and and CC cord-015021-pol2qm74 3229 25 lethality lethality NN cord-015021-pol2qm74 3229 26 . . . cord-015021-pol2qm74 3230 1 Antibodies antibody NNS cord-015021-pol2qm74 3230 2 to to IN cord-015021-pol2qm74 3230 3 TNF TNF NNP cord-015021-pol2qm74 3230 4 might may MD cord-015021-pol2qm74 3230 5 be be VB cord-015021-pol2qm74 3230 6 a a DT cord-015021-pol2qm74 3230 7 useful useful JJ cord-015021-pol2qm74 3230 8 agent agent NN cord-015021-pol2qm74 3230 9 in in IN cord-015021-pol2qm74 3230 10 the the DT cord-015021-pol2qm74 3230 11 treatment treatment NN cord-015021-pol2qm74 3230 12 of of IN cord-015021-pol2qm74 3230 13 haemorrhagic haemorrhagic JJ cord-015021-pol2qm74 3230 14 shock shock NN cord-015021-pol2qm74 3230 15 related relate VBN cord-015021-pol2qm74 3230 16 disorders disorder NNS cord-015021-pol2qm74 3230 17 . . . cord-015021-pol2qm74 3231 1 55-+8 55-+8 CD cord-015021-pol2qm74 3231 2 n n NN cord-015021-pol2qm74 3231 3 = = SYM cord-015021-pol2qm74 3231 4 ll*$ ll*$ NNP cord-015021-pol2qm74 3232 1 15-+5 15-+5 CD cord-015021-pol2qm74 3232 2 n=7 n=7 JJ cord-015021-pol2qm74 3232 3 78_+22 78_+22 CD cord-015021-pol2qm74 3233 1 n=5 n=5 JJ cord-015021-pol2qm74 3234 1 * * NFP cord-015021-pol2qm74 3234 2 * * NFP cord-015021-pol2qm74 3234 3 p<0.05 p<0.05 NN cord-015021-pol2qm74 3234 4 vs vs IN cord-015021-pol2qm74 3234 5 BASELINE BASELINE NNP cord-015021-pol2qm74 3234 6 : : : cord-015021-pol2qm74 3235 1 ~p<0.05 ~p<0.05 NFP cord-015021-pol2qm74 3236 1 no no DT cord-015021-pol2qm74 3236 2 anesthesia anesthesia NN cord-015021-pol2qm74 3236 3 vs vs IN cord-015021-pol2qm74 3236 4 anesthesia anesthesia NN cord-015021-pol2qm74 3237 1 Thus thus RB cord-015021-pol2qm74 3237 2 1 1 CD cord-015021-pol2qm74 3237 3 ) ) -RRB- cord-015021-pol2qm74 3237 4 TNF tnf NN cord-015021-pol2qm74 3237 5 production production NN cord-015021-pol2qm74 3237 6 increased increase VBD cord-015021-pol2qm74 3237 7 2 2 CD cord-015021-pol2qm74 3237 8 - - SYM cord-015021-pol2qm74 3237 9 3 3 CD cord-015021-pol2qm74 3237 10 fold fold VB cord-015021-pol2qm74 3237 11 by by IN cord-015021-pol2qm74 3237 12 48 48 CD cord-015021-pol2qm74 3237 13 - - SYM cord-015021-pol2qm74 3237 14 72 72 CD cord-015021-pol2qm74 3237 15 hrs hrs NN cord-015021-pol2qm74 3237 16 following follow VBG cord-015021-pol2qm74 3237 17 trauma trauma NN cord-015021-pol2qm74 3237 18 in in IN cord-015021-pol2qm74 3237 19 unstimulated unstimulated JJ cord-015021-pol2qm74 3237 20 blood blood NN cord-015021-pol2qm74 3237 21 , , , cord-015021-pol2qm74 3237 22 but but CC cord-015021-pol2qm74 3237 23 was be VBD cord-015021-pol2qm74 3237 24 reduced reduce VBN cord-015021-pol2qm74 3237 25 or or CC cord-015021-pol2qm74 3237 26 not not RB cord-015021-pol2qm74 3237 27 changed change VBN cord-015021-pol2qm74 3237 28 after after IN cord-015021-pol2qm74 3237 29 LPS LPS NNP cord-015021-pol2qm74 3237 30 stimulation stimulation NN cord-015021-pol2qm74 3237 31 , , , cord-015021-pol2qm74 3237 32 so so IN cord-015021-pol2qm74 3237 33 circulating circulate VBG cord-015021-pol2qm74 3237 34 leukocytes leukocyte NNS cord-015021-pol2qm74 3237 35 are be VBP cord-015021-pol2qm74 3237 36 probably probably RB cord-015021-pol2qm74 3237 37 not not RB cord-015021-pol2qm74 3237 38 an an DT cord-015021-pol2qm74 3237 39 important important JJ cord-015021-pol2qm74 3237 40 source source NN cord-015021-pol2qm74 3237 41 of of IN cord-015021-pol2qm74 3237 42 TNF TNF NNP cord-015021-pol2qm74 3237 43 post post NN cord-015021-pol2qm74 3237 44 trauma trauma NN cord-015021-pol2qm74 3237 45 ; ; : cord-015021-pol2qm74 3238 1 2 2 LS cord-015021-pol2qm74 3238 2 ) ) -RRB- cord-015021-pol2qm74 3238 3 antiCD18 antiCD18 NFP cord-015021-pol2qm74 3238 4 had have VBD cord-015021-pol2qm74 3238 5 no no DT cord-015021-pol2qm74 3238 6 obvious obvious JJ cord-015021-pol2qm74 3238 7 effect effect NN cord-015021-pol2qm74 3238 8 on on IN cord-015021-pol2qm74 3238 9 TNF TNF NNP cord-015021-pol2qm74 3238 10 production production NN cord-015021-pol2qm74 3238 11 in in IN cord-015021-pol2qm74 3238 12 unstimulated unstimulated JJ cord-015021-pol2qm74 3238 13 or or CC cord-015021-pol2qm74 3238 14 LPS lp NNS cord-015021-pol2qm74 3238 15 stimulated stimulate VBD cord-015021-pol2qm74 3238 16 blood blood NN cord-015021-pol2qm74 3238 17 , , , cord-015021-pol2qm74 3238 18 relative relative JJ cord-015021-pol2qm74 3238 19 to to IN cord-015021-pol2qm74 3238 20 vehicle vehicle NN cord-015021-pol2qm74 3238 21 , , , cord-015021-pol2qm74 3238 22 which which WDT cord-015021-pol2qm74 3238 23 suggests suggest VBZ cord-015021-pol2qm74 3238 24 that that IN cord-015021-pol2qm74 3238 25 the the DT cord-015021-pol2qm74 3238 26 protective protective JJ cord-015021-pol2qm74 3238 27 mechanism mechanism NN cord-015021-pol2qm74 3238 28 of of IN cord-015021-pol2qm74 3238 29 antiCD18 antiCD18 : cord-015021-pol2qm74 3238 30 does do VBZ cord-015021-pol2qm74 3238 31 not not RB cord-015021-pol2qm74 3238 32 involve involve VB cord-015021-pol2qm74 3238 33 TNF TNF NNP cord-015021-pol2qm74 3238 34 suppression suppression NN cord-015021-pol2qm74 3238 35 ; ; : cord-015021-pol2qm74 3238 36 3 3 LS cord-015021-pol2qm74 3238 37 ) ) -RRB- cord-015021-pol2qm74 3238 38 fentanyl fentanyl NN cord-015021-pol2qm74 3238 39 anesthesia anesthesia NN cord-015021-pol2qm74 3238 40 at at IN cord-015021-pol2qm74 3238 41 72 72 CD cord-015021-pol2qm74 3238 42 hrs hrs NN cord-015021-pol2qm74 3238 43 following follow VBG cord-015021-pol2qm74 3238 44 trauma trauma NN cord-015021-pol2qm74 3238 45 unexpectedly unexpectedly RB cord-015021-pol2qm74 3238 46 decreased decrease VBD cord-015021-pol2qm74 3238 47 LPS LPS NNP cord-015021-pol2qm74 3238 48 - - HYPH cord-015021-pol2qm74 3238 49 evoked evoke VBN cord-015021-pol2qm74 3238 50 TNF tnf NN cord-015021-pol2qm74 3238 51 production production NN cord-015021-pol2qm74 3238 52 , , , cord-015021-pol2qm74 3238 53 which which WDT cord-015021-pol2qm74 3238 54 suggests suggest VBZ cord-015021-pol2qm74 3238 55 that that IN cord-015021-pol2qm74 3238 56 anesthesia anesthesia NN cord-015021-pol2qm74 3238 57 alone alone RB cord-015021-pol2qm74 3238 58 can can MD cord-015021-pol2qm74 3238 59 influence influence VB cord-015021-pol2qm74 3238 60 an an DT cord-015021-pol2qm74 3238 61 inflammatory inflammatory JJ cord-015021-pol2qm74 3238 62 response response NN cord-015021-pol2qm74 3238 63 . . . cord-015021-pol2qm74 3239 1 Proinflamrnato~ Proinflamrnato~ NNP cord-015021-pol2qm74 3239 2 cytokines cytokine NNS cord-015021-pol2qm74 3239 3 have have VBP cord-015021-pol2qm74 3239 4 been be VBN cord-015021-pol2qm74 3239 5 shown show VBN cord-015021-pol2qm74 3239 6 to to TO cord-015021-pol2qm74 3239 7 play play VB cord-015021-pol2qm74 3239 8 a a DT cord-015021-pol2qm74 3239 9 signific signific NN cord-015021-pol2qm74 3239 10 ~ ~ NFP cord-015021-pol2qm74 3239 11 t t XX cord-015021-pol2qm74 3239 12 role role NN cord-015021-pol2qm74 3239 13 in in IN cord-015021-pol2qm74 3239 14 the the DT cord-015021-pol2qm74 3239 15 pathogenesis pathogenesis NN cord-015021-pol2qm74 3239 16 of of IN cord-015021-pol2qm74 3239 17 sepsis sepsis NN cord-015021-pol2qm74 3239 18 , , , cord-015021-pol2qm74 3239 19 which which WDT cord-015021-pol2qm74 3239 20 is be VBZ cord-015021-pol2qm74 3239 21 a a DT cord-015021-pol2qm74 3239 22 very very RB cord-015021-pol2qm74 3239 23 common common JJ cord-015021-pol2qm74 3239 24 occurrence occurrence NN cord-015021-pol2qm74 3239 25 in in IN cord-015021-pol2qm74 3239 26 born bear VBN cord-015021-pol2qm74 3239 27 injury injury NN cord-015021-pol2qm74 3239 28 . . . cord-015021-pol2qm74 3240 1 TNFa TNFa NNP cord-015021-pol2qm74 3240 2 is be VBZ cord-015021-pol2qm74 3240 3 infrequently infrequently RB cord-015021-pol2qm74 3240 4 detected detect VBN cord-015021-pol2qm74 3240 5 in in IN cord-015021-pol2qm74 3240 6 the the DT cord-015021-pol2qm74 3240 7 blood blood NN cord-015021-pol2qm74 3240 8 of of IN cord-015021-pol2qm74 3240 9 burned burn VBN cord-015021-pol2qm74 3240 10 patients patient NNS cord-015021-pol2qm74 3240 11 , , , cord-015021-pol2qm74 3240 12 the the DT cord-015021-pol2qm74 3240 13 ability ability NN cord-015021-pol2qm74 3240 14 to to TO cord-015021-pol2qm74 3240 15 detect detect VB cord-015021-pol2qm74 3240 16 the the DT cord-015021-pol2qm74 3240 17 shed shed JJ cord-015021-pol2qm74 3240 18 receptors receptor NNS cord-015021-pol2qm74 3240 19 of of IN cord-015021-pol2qm74 3240 20 sTNFg sTNFg NNP cord-015021-pol2qm74 3240 21 has have VBZ cord-015021-pol2qm74 3240 22 not not RB cord-015021-pol2qm74 3240 23 been be VBN cord-015021-pol2qm74 3240 24 determined determine VBN cord-015021-pol2qm74 3240 25 . . . cord-015021-pol2qm74 3241 1 Serial serial JJ cord-015021-pol2qm74 3241 2 serum serum NN cord-015021-pol2qm74 3241 3 Mmples Mmples NNPS cord-015021-pol2qm74 3241 4 from from IN cord-015021-pol2qm74 3241 5 burn burn NN cord-015021-pol2qm74 3241 6 patients patient NNS cord-015021-pol2qm74 3241 7 were be VBD cord-015021-pol2qm74 3241 8 collected collect VBN cord-015021-pol2qm74 3241 9 from from IN cord-015021-pol2qm74 3241 10 the the DT cord-015021-pol2qm74 3241 11 time time NN cord-015021-pol2qm74 3241 12 of of IN cord-015021-pol2qm74 3241 13 admission admission NN cord-015021-pol2qm74 3241 14 until until IN cord-015021-pol2qm74 3241 15 death death NN cord-015021-pol2qm74 3241 16 from from IN cord-015021-pol2qm74 3241 17 septic septic JJ cord-015021-pol2qm74 3241 18 shock shock NN cord-015021-pol2qm74 3241 19 . . . cord-015021-pol2qm74 3242 1 These these DT cord-015021-pol2qm74 3242 2 samples sample NNS cord-015021-pol2qm74 3242 3 were be VBD cord-015021-pol2qm74 3242 4 analyzed analyze VBN cord-015021-pol2qm74 3242 5 using use VBG cord-015021-pol2qm74 3242 6 an an DT cord-015021-pol2qm74 3242 7 enzyme enzyme NN cord-015021-pol2qm74 3242 8 - - HYPH cord-015021-pol2qm74 3242 9 linked link VBN cord-015021-pol2qm74 3242 10 immunosorbent immunosorbent JJ cord-015021-pol2qm74 3242 11 assay assay NN cord-015021-pol2qm74 3242 12 ( ( -LRB- cord-015021-pol2qm74 3242 13 ELISA ELISA NNP cord-015021-pol2qm74 3242 14 ) ) -RRB- cord-015021-pol2qm74 3242 15 for for IN cord-015021-pol2qm74 3242 16 sTNFr sTNFr NNP cord-015021-pol2qm74 3242 17 , , , cord-015021-pol2qm74 3242 18 L L NNP cord-015021-pol2qm74 3242 19 - - HYPH cord-015021-pol2qm74 3242 20 Ira Ira NNP cord-015021-pol2qm74 3242 21 , , , cord-015021-pol2qm74 3242 22 TNF TNF NNP cord-015021-pol2qm74 3242 23 - - HYPH cord-015021-pol2qm74 3242 24 a a NNP cord-015021-pol2qm74 3242 25 , , , cord-015021-pol2qm74 3242 26 and and CC cord-015021-pol2qm74 3242 27 IL IL NNP cord-015021-pol2qm74 3242 28 - - HYPH cord-015021-pol2qm74 3242 29 Ib Ib NNP cord-015021-pol2qm74 3242 30 . . . cord-015021-pol2qm74 3243 1 The the DT cord-015021-pol2qm74 3243 2 patients patient NNS cord-015021-pol2qm74 3243 3 ranged range VBD cord-015021-pol2qm74 3243 4 in in IN cord-015021-pol2qm74 3243 5 age age NN cord-015021-pol2qm74 3243 6 from from IN cord-015021-pol2qm74 3243 7 26 26 CD cord-015021-pol2qm74 3243 8 to to TO cord-015021-pol2qm74 3243 9 72 72 CD cord-015021-pol2qm74 3243 10 yeas yea NNS cord-015021-pol2qm74 3243 11 of of IN cord-015021-pol2qm74 3243 12 age age NN cord-015021-pol2qm74 3243 13 . . . cord-015021-pol2qm74 3244 1 The the DT cord-015021-pol2qm74 3244 2 percentages percentage NNS cord-015021-pol2qm74 3244 3 of of IN cord-015021-pol2qm74 3244 4 bum bum NN cord-015021-pol2qm74 3244 5 ranged range VBD cord-015021-pol2qm74 3244 6 from from IN cord-015021-pol2qm74 3244 7 40 40 CD cord-015021-pol2qm74 3244 8 % % NN cord-015021-pol2qm74 3244 9 -90 -90 NN cord-015021-pol2qm74 3244 10 % % NN cord-015021-pol2qm74 3244 11 . . . cord-015021-pol2qm74 3245 1 Cytokine cytokine NN cord-015021-pol2qm74 3245 2 concenlrntions concenlrntion NNS cord-015021-pol2qm74 3245 3 vmled vmle VBD cord-015021-pol2qm74 3245 4 from from IN cord-015021-pol2qm74 3245 5 patient patient NN cord-015021-pol2qm74 3245 6 to to IN cord-015021-pol2qm74 3245 7 padent padent NN cord-015021-pol2qm74 3245 8 irrespective irrespective RB cord-015021-pol2qm74 3245 9 of of IN cord-015021-pol2qm74 3245 10 bum bum JJ cord-015021-pol2qm74 3245 11 size size NN cord-015021-pol2qm74 3245 12 . . . cord-015021-pol2qm74 3246 1 TNFa TNFa NNP cord-015021-pol2qm74 3246 2 levels level NNS cord-015021-pol2qm74 3246 3 were be VBD cord-015021-pol2qm74 3246 4 consistentiy consistentiy NNS cord-015021-pol2qm74 3246 5 in in IN cord-015021-pol2qm74 3246 6 the the DT cord-015021-pol2qm74 3246 7 range range NN cord-015021-pol2qm74 3246 8 of30pgJml of30pgJml NNP cord-015021-pol2qm74 3246 9 -150pg -150pg NNP cord-015021-pol2qm74 3246 10 / / SYM cord-015021-pol2qm74 3246 11 ml ml NN cord-015021-pol2qm74 3246 12 . . . cord-015021-pol2qm74 3247 1 Peaks peak NNS cord-015021-pol2qm74 3247 2 in in IN cord-015021-pol2qm74 3247 3 the the DT cord-015021-pol2qm74 3247 4 TNFa TNFa NNS cord-015021-pol2qm74 3247 5 values value NNS cord-015021-pol2qm74 3247 6 were be VBD cord-015021-pol2qm74 3247 7 above above IN cord-015021-pol2qm74 3247 8 90pg 90pg NN cord-015021-pol2qm74 3247 9 / / SYM cord-015021-pol2qm74 3247 10 ml ml NN cord-015021-pol2qm74 3247 11 and and CC cord-015021-pol2qm74 3247 12 were be VBD cord-015021-pol2qm74 3247 13 also also RB cord-015021-pol2qm74 3247 14 associated associate VBN cord-015021-pol2qm74 3247 15 with with IN cord-015021-pol2qm74 3247 16 a a DT cord-015021-pol2qm74 3247 17 peak peak NN cord-015021-pol2qm74 3247 18 in in IN cord-015021-pol2qm74 3247 19 the the DT cord-015021-pol2qm74 3247 20 sTNFr stnfr CD cord-015021-pol2qm74 3247 21 levels level NNS cord-015021-pol2qm74 3247 22 . . . cord-015021-pol2qm74 3248 1 These these DT cord-015021-pol2qm74 3248 2 levels level NNS cord-015021-pol2qm74 3248 3 began begin VBD cord-015021-pol2qm74 3248 4 at at IN cord-015021-pol2qm74 3248 5 < < XX cord-015021-pol2qm74 3248 6 10,000pghnl 10,000pghnl CD cord-015021-pol2qm74 3248 7 within within IN cord-015021-pol2qm74 3248 8 the the DT cord-015021-pol2qm74 3248 9 In In NNP cord-015021-pol2qm74 3248 10 , , , cord-015021-pol2qm74 3248 11 st st NNP cord-015021-pol2qm74 3248 12 6 6 CD cord-015021-pol2qm74 3248 13 Ins Ins NNPS cord-015021-pol2qm74 3248 14 of of IN cord-015021-pol2qm74 3248 15 injury injury NN cord-015021-pol2qm74 3248 16 and and CC cord-015021-pol2qm74 3248 17 gradually gradually RB cord-015021-pol2qm74 3248 18 increased increase VBD cord-015021-pol2qm74 3248 19 with with IN cord-015021-pol2qm74 3248 20 time time NN cord-015021-pol2qm74 3248 21 . . . cord-015021-pol2qm74 3249 1 Clinically clinically RB cord-015021-pol2qm74 3249 2 . . . cord-015021-pol2qm74 3250 1 ti~ ti~ NNP cord-015021-pol2qm74 3250 2 appearance appearance NN cord-015021-pol2qm74 3250 3 of of IN cord-015021-pol2qm74 3250 4 eytoklnes eytoklne NNS cord-015021-pol2qm74 3250 5 was be VBD cord-015021-pol2qm74 3250 6 independent independent JJ cord-015021-pol2qm74 3250 7 of of IN cord-015021-pol2qm74 3250 8 positive positive JJ cord-015021-pol2qm74 3250 9 wound wound NN cord-015021-pol2qm74 3250 10 , , , cord-015021-pol2qm74 3250 11 blood blood NN cord-015021-pol2qm74 3250 12 , , , cord-015021-pol2qm74 3250 13 or or CC cord-015021-pol2qm74 3250 14 respiratory respiratory JJ cord-015021-pol2qm74 3250 15 cultures culture NNS cord-015021-pol2qm74 3250 16 however however RB cord-015021-pol2qm74 3250 17 peak peak VBP cord-015021-pol2qm74 3250 18 values value NNS cord-015021-pol2qm74 3250 19 in in IN cord-015021-pol2qm74 3250 20 TNFa TNFa NNS cord-015021-pol2qm74 3250 21 and and CC cord-015021-pol2qm74 3251 1 sTNFr sTNFr VBN cord-015021-pol2qm74 3251 2 were be VBD cord-015021-pol2qm74 3251 3 ~ialed ~iale VBN cord-015021-pol2qm74 3251 4 with with IN cord-015021-pol2qm74 3251 5 a a DT cord-015021-pol2qm74 3251 6 fluid fluid JJ cord-015021-pol2qm74 3251 7 requirnmenL requirnmenL NNP cord-015021-pol2qm74 3251 8 Levels level NNS cord-015021-pol2qm74 3251 9 of of IN cord-015021-pol2qm74 3251 10 IL IL NNP cord-015021-pol2qm74 3251 11 - - : cord-015021-pol2qm74 3251 12 I I NNP cord-015021-pol2qm74 3251 13 ra ra NNP cord-015021-pol2qm74 3251 14 were be VBD cord-015021-pol2qm74 3251 15 also also RB cord-015021-pol2qm74 3251 16 elevated elevate VBN cord-015021-pol2qm74 3251 17 independent independent JJ cord-015021-pol2qm74 3251 18 of of IN cord-015021-pol2qm74 3251 19 clinical clinical JJ cord-015021-pol2qm74 3251 20 findings finding NNS cord-015021-pol2qm74 3251 21 as as RB cord-015021-pol2qm74 3251 22 well well RB cord-015021-pol2qm74 3251 23 as as IN cord-015021-pol2qm74 3251 24 extent extent NN cord-015021-pol2qm74 3251 25 of of IN cord-015021-pol2qm74 3251 26 injury injury NN cord-015021-pol2qm74 3251 27 . . . cord-015021-pol2qm74 3252 1 In in IN cord-015021-pol2qm74 3252 2 PL5 PL5 NNP cord-015021-pol2qm74 3252 3 there there EX cord-015021-pol2qm74 3252 4 is be VBZ cord-015021-pol2qm74 3252 5 a a DT cord-015021-pol2qm74 3252 6 significant significant JJ cord-015021-pol2qm74 3252 7 corresponding corresponding JJ cord-015021-pol2qm74 3252 8 peak peak NN cord-015021-pol2qm74 3252 9 in in IN cord-015021-pol2qm74 3252 10 IL IL NNP cord-015021-pol2qm74 3252 11 - - HYPH cord-015021-pol2qm74 3252 12 trn trn NNP cord-015021-pol2qm74 3252 13 ( ( -LRB- cord-015021-pol2qm74 3252 14 > > NFP cord-015021-pol2qm74 3252 15 40~8 40~8 CD cord-015021-pol2qm74 3252 16 / / SYM cord-015021-pol2qm74 3252 17 ml ml NN cord-015021-pol2qm74 3252 18 ) ) -RRB- cord-015021-pol2qm74 3252 19 at at IN cord-015021-pol2qm74 3252 20 the the DT cord-015021-pol2qm74 3252 21 same same JJ cord-015021-pol2qm74 3252 22 time time NN cord-015021-pol2qm74 3252 23 as as IN cord-015021-pol2qm74 3252 24 T/~:a T/~:a NNP cord-015021-pol2qm74 3252 25 and and CC cord-015021-pol2qm74 3252 26 sTNFr stnfr CD cord-015021-pol2qm74 3252 27 levels level NNS cord-015021-pol2qm74 3252 28 . . . cord-015021-pol2qm74 3253 1 We -PRON- PRP cord-015021-pol2qm74 3253 2 aimed aim VBD cord-015021-pol2qm74 3253 3 to to TO cord-015021-pol2qm74 3253 4 characterise characterise VB cord-015021-pol2qm74 3253 5 the the DT cord-015021-pol2qm74 3253 6 pattern pattern NN cord-015021-pol2qm74 3253 7 of of IN cord-015021-pol2qm74 3253 8 secretion secretion NN cord-015021-pol2qm74 3253 9 of of IN cord-015021-pol2qm74 3253 10 interleukin-1 interleukin-1 NN cord-015021-pol2qm74 3253 11 beta beta NN cord-015021-pol2qm74 3253 12 0L 0l NN cord-015021-pol2qm74 3253 13 - - HYPH cord-015021-pol2qm74 3253 14 II3 ii3 JJ cord-015021-pol2qm74 3253 15 ) ) -RRB- cord-015021-pol2qm74 3253 16 , , , cord-015021-pol2qm74 3253 17 intefleukin-6 intefleukin-6 NNP cord-015021-pol2qm74 3253 18 ( ( -LRB- cord-015021-pol2qm74 3253 19 IL-6 IL-6 NNP cord-015021-pol2qm74 3253 20 ) ) -RRB- cord-015021-pol2qm74 3253 21 and and CC cord-015021-pol2qm74 3253 22 tumour tumour NN cord-015021-pol2qm74 3253 23 necrosis necrosis NN cord-015021-pol2qm74 3253 24 factor factor NN cord-015021-pol2qm74 3253 25 alpha alpha NN cord-015021-pol2qm74 3253 26 ( ( -LRB- cord-015021-pol2qm74 3253 27 TNFa TNFa NNP cord-015021-pol2qm74 3253 28 ) ) -RRB- cord-015021-pol2qm74 3253 29 in in IN cord-015021-pol2qm74 3253 30 multiply multiply NN cord-015021-pol2qm74 3253 31 injured injure VBN cord-015021-pol2qm74 3253 32 patients patient NNS cord-015021-pol2qm74 3253 33 and and CC cord-015021-pol2qm74 3253 34 to to TO cord-015021-pol2qm74 3253 35 relate relate VB cord-015021-pol2qm74 3253 36 these these DT cord-015021-pol2qm74 3253 37 results result NNS cord-015021-pol2qm74 3253 38 to to IN cord-015021-pol2qm74 3253 39 their -PRON- PRP$ cord-015021-pol2qm74 3253 40 clinical clinical JJ cord-015021-pol2qm74 3253 41 condition condition NN cord-015021-pol2qm74 3253 42 and and CC cord-015021-pol2qm74 3253 43 outcome outcome NN cord-015021-pol2qm74 3253 44 . . . cord-015021-pol2qm74 3254 1 Two two CD cord-015021-pol2qm74 3254 2 hourly hourly JJ cord-015021-pol2qm74 3254 3 blood blood NN cord-015021-pol2qm74 3254 4 samples sample NNS cord-015021-pol2qm74 3254 5 were be VBD cord-015021-pol2qm74 3254 6 taken take VBN cord-015021-pol2qm74 3254 7 from from IN cord-015021-pol2qm74 3254 8 ten ten CD cord-015021-pol2qm74 3254 9 patients patient NNS cord-015021-pol2qm74 3254 10 from from IN cord-015021-pol2qm74 3254 11 the the DT cord-015021-pol2qm74 3254 12 time time NN cord-015021-pol2qm74 3254 13 of of IN cord-015021-pol2qm74 3254 14 injury injury NN cord-015021-pol2qm74 3254 15 until until IN cord-015021-pol2qm74 3254 16 48 48 CD cord-015021-pol2qm74 3254 17 hours hour NNS cord-015021-pol2qm74 3254 18 . . . cord-015021-pol2qm74 3255 1 Cytokine cytokine NN cord-015021-pol2qm74 3255 2 levels level NNS cord-015021-pol2qm74 3255 3 were be VBD cord-015021-pol2qm74 3255 4 measured measure VBN cord-015021-pol2qm74 3255 5 using use VBG cord-015021-pol2qm74 3255 6 sandwich sandwich NN cord-015021-pol2qm74 3255 7 enzyme enzyme NN cord-015021-pol2qm74 3255 8 - - HYPH cord-015021-pol2qm74 3255 9 linked link VBN cord-015021-pol2qm74 3255 10 immunosorbent immunosorbent JJ cord-015021-pol2qm74 3255 11 assays assay NNS cord-015021-pol2qm74 3255 12 ( ( -LRB- cord-015021-pol2qm74 3255 13 ELISAs elisa NNS cord-015021-pol2qm74 3255 14 ) ) -RRB- cord-015021-pol2qm74 3255 15 . . . cord-015021-pol2qm74 3256 1 Injury injury NN cord-015021-pol2qm74 3256 2 Severity severity NN cord-015021-pol2qm74 3256 3 Scores score NNS cord-015021-pol2qm74 3256 4 ( ( -LRB- cord-015021-pol2qm74 3256 5 ISS ISS NNP cord-015021-pol2qm74 3256 6 ) ) -RRB- cord-015021-pol2qm74 3256 7 were be VBD cord-015021-pol2qm74 3256 8 calculated calculate VBN cord-015021-pol2qm74 3256 9 and and CC cord-015021-pol2qm74 3256 10 haemorrhage haemorrhage NN cord-015021-pol2qm74 3256 11 was be VBD cord-015021-pol2qm74 3256 12 assessed assess VBN cord-015021-pol2qm74 3256 13 from from IN cord-015021-pol2qm74 3256 14 the the DT cord-015021-pol2qm74 3256 15 blood blood NN cord-015021-pol2qm74 3256 16 transfusion transfusion NN cord-015021-pol2qm74 3256 17 requirement requirement NN cord-015021-pol2qm74 3256 18 over over IN cord-015021-pol2qm74 3256 19 the the DT cord-015021-pol2qm74 3256 20 48 48 CD cord-015021-pol2qm74 3256 21 hours hour NNS cord-015021-pol2qm74 3256 22 . . . cord-015021-pol2qm74 3257 1 Patients patient NNS cord-015021-pol2qm74 3257 2 ' ' POS cord-015021-pol2qm74 3257 3 ages age NNS cord-015021-pol2qm74 3257 4 ranged range VBD cord-015021-pol2qm74 3257 5 from from IN cord-015021-pol2qm74 3257 6 17 17 CD cord-015021-pol2qm74 3257 7 to to TO cord-015021-pol2qm74 3257 8 86 86 CD cord-015021-pol2qm74 3257 9 years year NNS cord-015021-pol2qm74 3257 10 . . . cord-015021-pol2qm74 3258 1 ISS ISS NNP cord-015021-pol2qm74 3258 2 varied vary VBD cord-015021-pol2qm74 3258 3 from from IN cord-015021-pol2qm74 3258 4 9 9 CD cord-015021-pol2qm74 3258 5 to to IN cord-015021-pol2qm74 3258 6 50 50 CD cord-015021-pol2qm74 3258 7 and and CC cord-015021-pol2qm74 3258 8 transfusion transfusion NN cord-015021-pol2qm74 3258 9 requirement requirement NN cord-015021-pol2qm74 3258 10 from from IN cord-015021-pol2qm74 3258 11 0 0 CD cord-015021-pol2qm74 3258 12 to to IN cord-015021-pol2qm74 3258 13 14 14 CD cord-015021-pol2qm74 3258 14 units unit NNS cord-015021-pol2qm74 3258 15 . . . cord-015021-pol2qm74 3259 1 Five five CD cord-015021-pol2qm74 3259 2 patients patient NNS cord-015021-pol2qm74 3259 3 died die VBD cord-015021-pol2qm74 3259 4 after after IN cord-015021-pol2qm74 3259 5 the the DT cord-015021-pol2qm74 3259 6 study study NN cord-015021-pol2qm74 3259 7 period period NN cord-015021-pol2qm74 3259 8 . . . cord-015021-pol2qm74 3259 9 ] ] -RRB- cord-015021-pol2qm74 3260 1 1,-6 1,-6 CD cord-015021-pol2qm74 3260 2 was be VBD cord-015021-pol2qm74 3260 3 raised raise VBN cord-015021-pol2qm74 3260 4 in in IN cord-015021-pol2qm74 3260 5 9/10 9/10 CD cord-015021-pol2qm74 3260 6 patients patient NNS cord-015021-pol2qm74 3260 7 ( ( -LRB- cord-015021-pol2qm74 3260 8 max max NNP cord-015021-pol2qm74 3260 9 level level NN cord-015021-pol2qm74 3260 10 12,500 12,500 CD cord-015021-pol2qm74 3260 11 pg pg NN cord-015021-pol2qm74 3260 12 / / SYM cord-015021-pol2qm74 3260 13 ml ml NN cord-015021-pol2qm74 3260 14 ) ) -RRB- cord-015021-pol2qm74 3260 15 but but CC cord-015021-pol2qm74 3260 16 was be VBD cord-015021-pol2qm74 3260 17 unrelated unrelated JJ cord-015021-pol2qm74 3260 18 to to IN cord-015021-pol2qm74 3260 19 condition condition NN cord-015021-pol2qm74 3260 20 or or CC cord-015021-pol2qm74 3260 21 outcome outcome NN cord-015021-pol2qm74 3260 22 . . . cord-015021-pol2qm74 3261 1 5/8 5/8 CD cord-015021-pol2qm74 3261 2 showed show VBD cord-015021-pol2qm74 3261 3 a a DT cord-015021-pol2qm74 3261 4 rise rise NN cord-015021-pol2qm74 3261 5 in in IN cord-015021-pol2qm74 3261 6 IL-1B IL-1B NNP cord-015021-pol2qm74 3261 7 ( ( -LRB- cord-015021-pol2qm74 3261 8 max max NNP cord-015021-pol2qm74 3261 9 level level NN cord-015021-pol2qm74 3261 10 90 90 CD cord-015021-pol2qm74 3261 11 pg pg NN cord-015021-pol2qm74 3261 12 / / SYM cord-015021-pol2qm74 3261 13 ml ml NN cord-015021-pol2qm74 3261 14 ) ) -RRB- cord-015021-pol2qm74 3261 15 which which WDT cord-015021-pol2qm74 3261 16 was be VBD cord-015021-pol2qm74 3261 17 negatively negatively RB cord-015021-pol2qm74 3261 18 correlated correlate VBN cord-015021-pol2qm74 3261 19 to to IN cord-015021-pol2qm74 3261 20 ISS ISS NNP cord-015021-pol2qm74 3261 21 ( ( -LRB- cord-015021-pol2qm74 3261 22 I=-0.789 I=-0.789 NNP cord-015021-pol2qm74 3261 23 , , , cord-015021-pol2qm74 3261 24 p<0.02 p<0.02 XX cord-015021-pol2qm74 3261 25 ) ) -RRB- cord-015021-pol2qm74 3261 26 . . . cord-015021-pol2qm74 3262 1 TNFa TNFa NNP cord-015021-pol2qm74 3262 2 was be VBD cord-015021-pol2qm74 3262 3 raised raise VBN cord-015021-pol2qm74 3262 4 in in IN cord-015021-pol2qm74 3262 5 2/10 2/10 CD cord-015021-pol2qm74 3262 6 ( ( -LRB- cord-015021-pol2qm74 3262 7 max max NNP cord-015021-pol2qm74 3262 8 level level NN cord-015021-pol2qm74 3262 9 95 95 CD cord-015021-pol2qm74 3262 10 pg pg NN cord-015021-pol2qm74 3262 11 / / SYM cord-015021-pol2qm74 3262 12 ml ml NN cord-015021-pol2qm74 3262 13 ) ) -RRB- cord-015021-pol2qm74 3262 14 . . . cord-015021-pol2qm74 3263 1 Peak Peak NNP cord-015021-pol2qm74 3263 2 TNFc~ TNFc~ NNP cord-015021-pol2qm74 3263 3 was be VBD cord-015021-pol2qm74 3263 4 positively positively RB cord-015021-pol2qm74 3263 5 correlated correlate VBN cord-015021-pol2qm74 3263 6 with with IN cord-015021-pol2qm74 3263 7 ISS ISS NNP cord-015021-pol2qm74 3263 8 ( ( -LRB- cord-015021-pol2qm74 3263 9 1=0.676 1=0.676 CD cord-015021-pol2qm74 3263 10 , , , cord-015021-pol2qm74 3263 11 p<0.05 p<0.05 CD cord-015021-pol2qm74 3263 12 ) ) -RRB- cord-015021-pol2qm74 3263 13 and and CC cord-015021-pol2qm74 3263 14 haemorrhage haemorrhage NN cord-015021-pol2qm74 3263 15 ( ( -LRB- cord-015021-pol2qm74 3263 16 I=0.602 i=0.602 JJ cord-015021-pol2qm74 3263 17 but but CC cord-015021-pol2qm74 3263 18 p<0.5 p<0.5 NNP cord-015021-pol2qm74 3263 19 ) ) -RRB- cord-015021-pol2qm74 3263 20 . . . cord-015021-pol2qm74 3264 1 IL IL NNP cord-015021-pol2qm74 3264 2 - - HYPH cord-015021-pol2qm74 3264 3 IB IB NNP cord-015021-pol2qm74 3264 4 and and CC cord-015021-pol2qm74 3264 5 TNFa TNFa NNP cord-015021-pol2qm74 3264 6 production production NN cord-015021-pol2qm74 3264 7 was be VBD cord-015021-pol2qm74 3264 8 mutually mutually RB cord-015021-pol2qm74 3264 9 exclusive exclusive JJ cord-015021-pol2qm74 3264 10 . . . cord-015021-pol2qm74 3265 1 There there EX cord-015021-pol2qm74 3265 2 was be VBD cord-015021-pol2qm74 3265 3 no no DT cord-015021-pol2qm74 3265 4 common common JJ cord-015021-pol2qm74 3265 5 cytokine cytokine NN cord-015021-pol2qm74 3265 6 profile profile NN cord-015021-pol2qm74 3265 7 for for IN cord-015021-pol2qm74 3265 8 these these DT cord-015021-pol2qm74 3265 9 patients patient NNS cord-015021-pol2qm74 3265 10 . . . cord-015021-pol2qm74 3266 1 Unlike unlike IN cord-015021-pol2qm74 3266 2 elective elective JJ cord-015021-pol2qm74 3266 3 surgery surgery NN cord-015021-pol2qm74 3266 4 there there EX cord-015021-pol2qm74 3266 5 was be VBD cord-015021-pol2qm74 3266 6 no no DT cord-015021-pol2qm74 3266 7 correlation correlation NN cord-015021-pol2qm74 3266 8 between between IN cord-015021-pol2qm74 3266 9 peak peak NN cord-015021-pol2qm74 3266 10 11,-6 11,-6 CD cord-015021-pol2qm74 3266 11 and and CC cord-015021-pol2qm74 3266 12 severity severity NN cord-015021-pol2qm74 3266 13 of of IN cord-015021-pol2qm74 3266 14 injury injury NN cord-015021-pol2qm74 3267 1 : : : cord-015021-pol2qm74 3267 2 tissue tissue NN cord-015021-pol2qm74 3267 3 damage damage NN cord-015021-pol2qm74 3267 4 may may MD cord-015021-pol2qm74 3267 5 not not RB cord-015021-pol2qm74 3267 6 be be VB cord-015021-pol2qm74 3267 7 the the DT cord-015021-pol2qm74 3267 8 stimulus stimulus NN cord-015021-pol2qm74 3267 9 for for IN cord-015021-pol2qm74 3267 10 the the DT cord-015021-pol2qm74 3267 11 cytokine cytokine NN cord-015021-pol2qm74 3267 12 response response NN cord-015021-pol2qm74 3267 13 to to IN cord-015021-pol2qm74 3267 14 multiple multiple JJ cord-015021-pol2qm74 3267 15 injury injury NN cord-015021-pol2qm74 3267 16 . . . cord-015021-pol2qm74 3268 1 Periods period NNS cord-015021-pol2qm74 3268 2 of of IN cord-015021-pol2qm74 3268 3 ischemia ischemia NN cord-015021-pol2qm74 3268 4 or or CC cord-015021-pol2qm74 3268 5 hypoxia hypoxia NN cord-015021-pol2qm74 3268 6 produce produce VBP cord-015021-pol2qm74 3268 7 endothelial endothelial JJ cord-015021-pol2qm74 3268 8 damage damage NN cord-015021-pol2qm74 3268 9 in in IN cord-015021-pol2qm74 3268 10 peripheral peripheral JJ cord-015021-pol2qm74 3268 11 organs organ NNS cord-015021-pol2qm74 3268 12 . . . cord-015021-pol2qm74 3269 1 Tumor tumor NN cord-015021-pol2qm74 3269 2 necrosis necrosis NN cord-015021-pol2qm74 3269 3 factor factor NN cord-015021-pol2qm74 3269 4 - - HYPH cord-015021-pol2qm74 3269 5 alpha alpha NN cord-015021-pol2qm74 3269 6 ( ( -LRB- cord-015021-pol2qm74 3269 7 TNF TNF NNP cord-015021-pol2qm74 3269 8 ) ) -RRB- cord-015021-pol2qm74 3269 9 plays play VBZ cord-015021-pol2qm74 3269 10 a a DT cord-015021-pol2qm74 3269 11 central central JJ cord-015021-pol2qm74 3269 12 role role NN cord-015021-pol2qm74 3269 13 for for IN cord-015021-pol2qm74 3269 14 regulation regulation NN cord-015021-pol2qm74 3269 15 of of IN cord-015021-pol2qm74 3269 16 endothelial endothelial JJ cord-015021-pol2qm74 3269 17 physiology physiology NN cord-015021-pol2qm74 3269 18 during during IN cord-015021-pol2qm74 3269 19 septic septic JJ cord-015021-pol2qm74 3269 20 events event NNS cord-015021-pol2qm74 3269 21 , , , cord-015021-pol2qm74 3269 22 taking take VBG cord-015021-pol2qm74 3269 23 influence influence NN cord-015021-pol2qm74 3269 24 on on IN cord-015021-pol2qm74 3269 25 vascular vascular JJ cord-015021-pol2qm74 3269 26 permeability permeability NN cord-015021-pol2qm74 3269 27 and and CC cord-015021-pol2qm74 3269 28 coagulant coagulant NN cord-015021-pol2qm74 3269 29 activity activity NN cord-015021-pol2qm74 3269 30 [ [ -LRB- cord-015021-pol2qm74 3269 31 1 1 CD cord-015021-pol2qm74 3269 32 ] ] -RRB- cord-015021-pol2qm74 3269 33 . . . cord-015021-pol2qm74 3270 1 Animal animal NN cord-015021-pol2qm74 3270 2 experiments experiment NNS cord-015021-pol2qm74 3270 3 demonstrated demonstrate VBD cord-015021-pol2qm74 3270 4 a a DT cord-015021-pol2qm74 3270 5 synergism synergism NN cord-015021-pol2qm74 3270 6 between between IN cord-015021-pol2qm74 3270 7 hypoxia hypoxia NN cord-015021-pol2qm74 3270 8 and and CC cord-015021-pol2qm74 3270 9 septic septic JJ cord-015021-pol2qm74 3270 10 shock shock NN cord-015021-pol2qm74 3270 11 on on IN cord-015021-pol2qm74 3270 12 letality letality NN cord-015021-pol2qm74 3270 13 , , , cord-015021-pol2qm74 3270 14 leading lead VBG cord-015021-pol2qm74 3270 15 to to IN cord-015021-pol2qm74 3270 16 the the DT cord-015021-pol2qm74 3270 17 hypothesis hypothesis NN cord-015021-pol2qm74 3270 18 that that IN cord-015021-pol2qm74 3270 19 low low JJ cord-015021-pol2qm74 3270 20 oxygen oxygen NN cord-015021-pol2qm74 3270 21 tension tension NN cord-015021-pol2qm74 3270 22 leads lead VBZ cord-015021-pol2qm74 3270 23 to to IN cord-015021-pol2qm74 3270 24 enhanced enhanced JJ cord-015021-pol2qm74 3270 25 sensitivity sensitivity NN cord-015021-pol2qm74 3270 26 of of IN cord-015021-pol2qm74 3270 27 target target NN cord-015021-pol2qm74 3270 28 cells cell NNS cord-015021-pol2qm74 3270 29 for for IN cord-015021-pol2qm74 3270 30 TNF TNF NNP cord-015021-pol2qm74 3270 31 [ [ -LRB- cord-015021-pol2qm74 3270 32 2 2 CD cord-015021-pol2qm74 3270 33 ] ] -RRB- cord-015021-pol2qm74 3270 34 . . . cord-015021-pol2qm74 3271 1 Radioligand radioligand JJ cord-015021-pol2qm74 3271 2 binding binding JJ cord-015021-pol2qm74 3271 3 studies study NNS cord-015021-pol2qm74 3271 4 with with IN cord-015021-pol2qm74 3271 5 ~261odid ~261odid NNP cord-015021-pol2qm74 3271 6 - - HYPH cord-015021-pol2qm74 3271 7 TNF TNF NNP cord-015021-pol2qm74 3271 8 on on IN cord-015021-pol2qm74 3271 9 cultured cultured JJ cord-015021-pol2qm74 3271 10 human human JJ cord-015021-pol2qm74 3271 11 endothelial endothelial JJ cord-015021-pol2qm74 3271 12 cells cell NNS cord-015021-pol2qm74 3271 13 were be VBD cord-015021-pol2qm74 3271 14 performed perform VBN cord-015021-pol2qm74 3271 15 after after IN cord-015021-pol2qm74 3271 16 incubation incubation NN cord-015021-pol2qm74 3271 17 in in IN cord-015021-pol2qm74 3271 18 several several JJ cord-015021-pol2qm74 3271 19 environmental environmental JJ cord-015021-pol2qm74 3271 20 oxygen oxygen NN cord-015021-pol2qm74 3271 21 tensions tension NNS cord-015021-pol2qm74 3271 22 ( ( -LRB- cord-015021-pol2qm74 3271 23 PC2 PC2 NNP cord-015021-pol2qm74 3271 24 ) ) -RRB- cord-015021-pol2qm74 3271 25 for for IN cord-015021-pol2qm74 3271 26 12 12 CD cord-015021-pol2qm74 3271 27 hours hour NNS cord-015021-pol2qm74 3271 28 . . . cord-015021-pol2qm74 3272 1 Data datum NNS cord-015021-pol2qm74 3272 2 were be VBD cord-015021-pol2qm74 3272 3 achieved achieve VBN cord-015021-pol2qm74 3272 4 by by IN cord-015021-pol2qm74 3272 5 nonlinear nonlinear JJ cord-015021-pol2qm74 3272 6 regression regression NN cord-015021-pol2qm74 3272 7 of of IN cord-015021-pol2qm74 3272 8 an an DT cord-015021-pol2qm74 3272 9 idealized idealized JJ cord-015021-pol2qm74 3272 10 saturation saturation NN cord-015021-pol2qm74 3272 11 curve curve NN cord-015021-pol2qm74 3272 12 according accord VBG cord-015021-pol2qm74 3272 13 to to IN cord-015021-pol2qm74 3272 14 the the DT cord-015021-pol2qm74 3272 15 equation equation NN cord-015021-pol2qm74 3272 16 : : : cord-015021-pol2qm74 3273 1 B b NN cord-015021-pol2qm74 3273 2 = = SYM cord-015021-pol2qm74 3273 3 n n NN cord-015021-pol2qm74 3273 4 " " `` cord-015021-pol2qm74 3273 5 K./(1 k./(1 NN cord-015021-pol2qm74 3274 1 + + CC cord-015021-pol2qm74 3274 2 K K NNP cord-015021-pol2qm74 3274 3 , , , cord-015021-pol2qm74 3274 4 ) ) -RRB- cord-015021-pol2qm74 3274 5 ; ; : cord-015021-pol2qm74 3274 6 B b NN cord-015021-pol2qm74 3274 7 = = NFP cord-015021-pol2qm74 3274 8 totally totally RB cord-015021-pol2qm74 3274 9 bound bind VBN cord-015021-pol2qm74 3274 10 TNF TNF NNP cord-015021-pol2qm74 3274 11 ; ; : cord-015021-pol2qm74 3274 12 K K NNP cord-015021-pol2qm74 3274 13 , , , cord-015021-pol2qm74 3274 14 : : : cord-015021-pol2qm74 3274 15 association association NN cord-015021-pol2qm74 3274 16 constant constant NN cord-015021-pol2qm74 3274 17 ( ( -LRB- cord-015021-pol2qm74 3274 18 concentration concentration NN cord-015021-pol2qm74 3274 19 for for IN cord-015021-pol2qm74 3274 20 half half RB cord-015021-pol2qm74 3274 21 - - HYPH cord-015021-pol2qm74 3274 22 maximal maximal JJ cord-015021-pol2qm74 3274 23 binding binding NN cord-015021-pol2qm74 3274 24 ) ) -RRB- cord-015021-pol2qm74 3274 25 ; ; : cord-015021-pol2qm74 3274 26 n n CC cord-015021-pol2qm74 3274 27 : : : cord-015021-pol2qm74 3274 28 number number NN cord-015021-pol2qm74 3274 29 of of IN cord-015021-pol2qm74 3274 30 binding bind VBG cord-015021-pol2qm74 3274 31 sites site NNS cord-015021-pol2qm74 3274 32 per per IN cord-015021-pol2qm74 3274 33 cell cell NN cord-015021-pol2qm74 3274 34 . . . cord-015021-pol2qm74 3275 1 p_O0o p_O0o NFP cord-015021-pol2qm74 3276 1 ( ( -LRB- cord-015021-pol2qm74 3276 2 mm mm NNP cord-015021-pol2qm74 3277 1 H¢I h¢i LS cord-015021-pol2qm74 3277 2 ) ) -RRB- cord-015021-pol2qm74 3277 3 : : : cord-015021-pol2qm74 3278 1 _ _ NNP cord-015021-pol2qm74 3278 2 K K NNP cord-015021-pol2qm74 3278 3 , , , cord-015021-pol2qm74 3278 4 ( ( -LRB- cord-015021-pol2qm74 3278 5 nM nm NN cord-015021-pol2qm74 3278 6 } } -RRB- cord-015021-pol2qm74 3278 7 : : : cord-015021-pol2qm74 3278 8 n n LS cord-015021-pol2qm74 3278 9 ( ( -LRB- cord-015021-pol2qm74 3278 10 molecules molecule NNS cord-015021-pol2qm74 3278 11 / / SYM cord-015021-pol2qm74 3278 12 cell cell NN cord-015021-pol2qm74 3278 13 ) ) -RRB- cord-015021-pol2qm74 3278 14 : : : cord-015021-pol2qm74 3278 15 130 130 CD cord-015021-pol2qm74 3278 16 -150 -150 NN cord-015021-pol2qm74 3278 17 1.83 1.83 CD cord-015021-pol2qm74 3278 18 ± ± CD cord-015021-pol2qm74 3278 19 0.15 0.15 CD cord-015021-pol2qm74 3278 20 2600 2600 CD cord-015021-pol2qm74 3279 1 _ _ NNP cord-015021-pol2qm74 3279 2 + + CC cord-015021-pol2qm74 3280 1 500 500 CD cord-015021-pol2qm74 3280 2 55 55 CD cord-015021-pol2qm74 3280 3 -70 -70 NN cord-015021-pol2qm74 3280 4 1.27 1.27 CD cord-015021-pol2qm74 3280 5 ± ± NN cord-015021-pol2qm74 3281 1 0.15 0.15 CD cord-015021-pol2qm74 3281 2 3600 3600 CD cord-015021-pol2qm74 3281 3 + + SYM cord-015021-pol2qm74 3281 4 500 500 CD cord-015021-pol2qm74 3281 5 25 25 CD cord-015021-pol2qm74 3282 1 -35 -35 NNP cord-015021-pol2qm74 3282 2 0,41 0,41 ADD cord-015021-pol2qm74 3283 1 ± ± CD cord-015021-pol2qm74 3283 2 0.13 0.13 CD cord-015021-pol2qm74 3283 3 4800 4800 CD cord-015021-pol2qm74 3284 1 -+ -+ . cord-015021-pol2qm74 3285 1 500 500 CD cord-015021-pol2qm74 3285 2 10 10 CD cord-015021-pol2qm74 3285 3 - - SYM cord-015021-pol2qm74 3285 4 15 15 CD cord-015021-pol2qm74 3285 5 0.18 0.18 CD cord-015021-pol2qm74 3285 6 + + CD cord-015021-pol2qm74 3285 7 0.07 0.07 CD cord-015021-pol2qm74 3285 8 5900 5900 CD cord-015021-pol2qm74 3286 1 -+ -+ NNP cord-015021-pol2qm74 3286 2 300 300 CD cord-015021-pol2qm74 3286 3 Presented present VBN cord-015021-pol2qm74 3286 4 are be VBP cord-015021-pol2qm74 3286 5 calculated calculate VBN cord-015021-pol2qm74 3286 6 values value NNS cord-015021-pol2qm74 3286 7 on on IN cord-015021-pol2qm74 3286 8 the the DT cord-015021-pol2qm74 3286 9 idealized idealized JJ cord-015021-pol2qm74 3286 10 curve curve NN cord-015021-pol2qm74 3286 11 + + CC cord-015021-pol2qm74 3286 12 95 95 CD cord-015021-pol2qm74 3286 13 % % NN cord-015021-pol2qm74 3286 14 percentiles percentile NNS cord-015021-pol2qm74 3286 15 . . . cord-015021-pol2qm74 3287 1 Hypoxia hypoxia NN cord-015021-pol2qm74 3287 2 induces induce VBZ cord-015021-pol2qm74 3287 3 enhanced enhance VBN cord-015021-pol2qm74 3287 4 binding binding NN cord-015021-pol2qm74 3287 5 of of IN cord-015021-pol2qm74 3287 6 TNF TNF NNP cord-015021-pol2qm74 3287 7 to to TO cord-015021-pol2qm74 3287 8 specific specific JJ cord-015021-pol2qm74 3287 9 receptors receptor NNS cord-015021-pol2qm74 3287 10 on on IN cord-015021-pol2qm74 3287 11 the the DT cord-015021-pol2qm74 3287 12 endothelial endothelial JJ cord-015021-pol2qm74 3287 13 cell cell NN cord-015021-pol2qm74 3287 14 surface surface NN cord-015021-pol2qm74 3287 15 in in IN cord-015021-pol2qm74 3287 16 a a DT cord-015021-pol2qm74 3287 17 time time NN cord-015021-pol2qm74 3287 18 - - : cord-015021-pol2qm74 3287 19 and and CC cord-015021-pol2qm74 3287 20 dose dose NN cord-015021-pol2qm74 3287 21 - - HYPH cord-015021-pol2qm74 3287 22 dependent dependent JJ cord-015021-pol2qm74 3287 23 manner manner NN cord-015021-pol2qm74 3287 24 by by IN cord-015021-pol2qm74 3287 25 a a DT cord-015021-pol2qm74 3287 26 mechanism mechanism NN cord-015021-pol2qm74 3287 27 , , , cord-015021-pol2qm74 3287 28 which which WDT cord-015021-pol2qm74 3287 29 is be VBZ cord-015021-pol2qm74 3287 30 not not RB cord-015021-pol2qm74 3287 31 dependent dependent JJ cord-015021-pol2qm74 3287 32 on on IN cord-015021-pol2qm74 3287 33 oxygen oxygen NN cord-015021-pol2qm74 3287 34 radicals radical NNS cord-015021-pol2qm74 3287 35 , , , cord-015021-pol2qm74 3287 36 as as IN cord-015021-pol2qm74 3287 37 shown show VBN cord-015021-pol2qm74 3287 38 by by IN cord-015021-pol2qm74 3287 39 additional additional JJ cord-015021-pol2qm74 3287 40 protocols protocol NNS cord-015021-pol2qm74 3287 41 with with IN cord-015021-pol2qm74 3287 42 radical radical JJ cord-015021-pol2qm74 3287 43 - - HYPH cord-015021-pol2qm74 3287 44 scavenging scavenge VBG cord-015021-pol2qm74 3287 45 drugs drug NNS cord-015021-pol2qm74 3287 46 . . . cord-015021-pol2qm74 3288 1 With with IN cord-015021-pol2qm74 3288 2 respect respect NN cord-015021-pol2qm74 3288 3 to to IN cord-015021-pol2qm74 3288 4 former former JJ cord-015021-pol2qm74 3288 5 findings finding NNS cord-015021-pol2qm74 3288 6 about about IN cord-015021-pol2qm74 3288 7 a a DT cord-015021-pol2qm74 3288 8 correlation correlation NN cord-015021-pol2qm74 3288 9 between between IN cord-015021-pol2qm74 3288 10 growth growth NN cord-015021-pol2qm74 3288 11 and and CC cord-015021-pol2qm74 3288 12 TNF TNF NNP cord-015021-pol2qm74 3288 13 receptor receptor NN cord-015021-pol2qm74 3288 14 affinity affinity NN cord-015021-pol2qm74 3288 15 [ [ -LRB- cord-015021-pol2qm74 3288 16 3 3 CD cord-015021-pol2qm74 3288 17 ] ] -RRB- cord-015021-pol2qm74 3288 18 , , , cord-015021-pol2qm74 3288 19 these these DT cord-015021-pol2qm74 3288 20 data datum NNS cord-015021-pol2qm74 3288 21 lead lead VBP cord-015021-pol2qm74 3288 22 to to IN cord-015021-pol2qm74 3288 23 the the DT cord-015021-pol2qm74 3288 24 hypothesis hypothesis NN cord-015021-pol2qm74 3288 25 that that WDT cord-015021-pol2qm74 3288 26 enhanced enhance VBD cord-015021-pol2qm74 3288 27 TNF TNF NNP cord-015021-pol2qm74 3288 28 binding bind VBG cord-015021-pol2qm74 3288 29 during during IN cord-015021-pol2qm74 3288 30 hypoxia hypoxia NN cord-015021-pol2qm74 3288 31 is be VBZ cord-015021-pol2qm74 3288 32 due due JJ cord-015021-pol2qm74 3288 33 to to IN cord-015021-pol2qm74 3288 34 a a DT cord-015021-pol2qm74 3288 35 biochemical biochemical JJ cord-015021-pol2qm74 3288 36 conversion conversion NN cord-015021-pol2qm74 3288 37 of of IN cord-015021-pol2qm74 3288 38 the the DT cord-015021-pol2qm74 3288 39 receptor receptor NN cord-015021-pol2qm74 3288 40 protein protein NN cord-015021-pol2qm74 3288 41 from from IN cord-015021-pol2qm74 3288 42 the the DT cord-015021-pol2qm74 3288 43 low low JJ cord-015021-pol2qm74 3288 44 affinity affinity NN cord-015021-pol2qm74 3288 45 to to IN cord-015021-pol2qm74 3288 46 the the DT cord-015021-pol2qm74 3288 47 high high JJ cord-015021-pol2qm74 3288 48 affinity affinity NN cord-015021-pol2qm74 3288 49 state state NN cord-015021-pol2qm74 3288 50 , , , cord-015021-pol2qm74 3288 51 possibly possibly RB cord-015021-pol2qm74 3288 52 by by IN cord-015021-pol2qm74 3288 53 posttranslational posttranslational JJ cord-015021-pol2qm74 3288 54 phosphorylation phosphorylation NN cord-015021-pol2qm74 3288 55 of of IN cord-015021-pol2qm74 3288 56 the the DT cord-015021-pol2qm74 3288 57 binding bind VBG cord-015021-pol2qm74 3288 58 protein protein NN cord-015021-pol2qm74 3288 59 by by IN cord-015021-pol2qm74 3288 60 intracel)ular intracel)ular NNP cord-015021-pol2qm74 3288 61 kinases kinase NNS cord-015021-pol2qm74 3288 62 . . . cord-015021-pol2qm74 3289 1 The the DT cord-015021-pol2qm74 3289 2 proposed propose VBN cord-015021-pol2qm74 3289 3 involvement involvement NN cord-015021-pol2qm74 3289 4 of of IN cord-015021-pol2qm74 3289 5 TNF TNF NNP cord-015021-pol2qm74 3289 6 - - HYPH cord-015021-pol2qm74 3289 7 dependent dependent JJ cord-015021-pol2qm74 3289 8 pathways pathway NNS cord-015021-pol2qm74 3289 9 in in IN cord-015021-pol2qm74 3289 10 pathogenesis pathogenesis NN cord-015021-pol2qm74 3289 11 of of IN cord-015021-pol2qm74 3289 12 organ organ NN cord-015021-pol2qm74 3289 13 dysfunction dysfunction NN cord-015021-pol2qm74 3289 14 and and CC cord-015021-pol2qm74 3289 15 multiple multiple JJ cord-015021-pol2qm74 3289 16 organ organ NN cord-015021-pol2qm74 3289 17 failure failure NN cord-015021-pol2qm74 3289 18 after after IN cord-015021-pol2qm74 3289 19 hypoxia hypoxia NN cord-015021-pol2qm74 3289 20 / / SYM cord-015021-pol2qm74 3289 21 ischemia ischemia NN cord-015021-pol2qm74 3289 22 may may MD cord-015021-pol2qm74 3289 23 provide provide VB cord-015021-pol2qm74 3289 24 a a DT cord-015021-pol2qm74 3289 25 basis basis NN cord-015021-pol2qm74 3289 26 for for IN cord-015021-pol2qm74 3289 27 understanding understand VBG cord-015021-pol2qm74 3289 28 the the DT cord-015021-pol2qm74 3289 29 initiation initiation NN cord-015021-pol2qm74 3289 30 of of IN cord-015021-pol2qm74 3289 31 hypoxic hypoxic JJ cord-015021-pol2qm74 3289 32 vascular vascular JJ cord-015021-pol2qm74 3289 33 injury injury NN cord-015021-pol2qm74 3289 34 , , , cord-015021-pol2qm74 3289 35 as as IN cord-015021-pol2qm74 3289 36 manifested manifest VBN cord-015021-pol2qm74 3289 37 by by IN cord-015021-pol2qm74 3289 38 increased increase VBN cord-015021-pol2qm74 3289 39 permeability permeability NN cord-015021-pol2qm74 3289 40 and and CC cord-015021-pol2qm74 3289 41 prothrombotic prothrombotic JJ cord-015021-pol2qm74 3289 42 tendency tendency NN cord-015021-pol2qm74 3289 43 , , , cord-015021-pol2qm74 3289 44 and and CC cord-015021-pol2qm74 3289 45 , , , cord-015021-pol2qm74 3289 46 thus thus RB cord-015021-pol2qm74 3289 47 , , , cord-015021-pol2qm74 3289 48 merits merit NNS cord-015021-pol2qm74 3289 49 further further JJ cord-015021-pol2qm74 3289 50 attention attention NN cord-015021-pol2qm74 3289 51 . . . cord-015021-pol2qm74 3290 1 The the DT cord-015021-pol2qm74 3290 2 levels level NNS cord-015021-pol2qm74 3290 3 of of IN cord-015021-pol2qm74 3290 4 activity activity NN cord-015021-pol2qm74 3290 5 of of IN cord-015021-pol2qm74 3290 6 circulating circulate VBG cord-015021-pol2qm74 3290 7 cytokines cytokine NNS cord-015021-pol2qm74 3290 8 ( ( -LRB- cord-015021-pol2qm74 3290 9 ILl ILl NNP cord-015021-pol2qm74 3290 10 , , , cord-015021-pol2qm74 3290 11 IL-6 IL-6 NNP cord-015021-pol2qm74 3290 12 and and CC cord-015021-pol2qm74 3290 13 TNF TNF NNP cord-015021-pol2qm74 3290 14 - - HYPH cord-015021-pol2qm74 3290 15 alpha alpha NN cord-015021-pol2qm74 3290 16 ) ) -RRB- cord-015021-pol2qm74 3290 17 which which WDT cord-015021-pol2qm74 3290 18 are be VBP cord-015021-pol2qm74 3290 19 believed believe VBN cord-015021-pol2qm74 3290 20 to to TO cord-015021-pol2qm74 3290 21 play play VB cord-015021-pol2qm74 3290 22 important important JJ cord-015021-pol2qm74 3290 23 regulatory regulatory JJ cord-015021-pol2qm74 3290 24 role role NN cord-015021-pol2qm74 3290 25 in in IN cord-015021-pol2qm74 3290 26 response response NN cord-015021-pol2qm74 3290 27 to to IN cord-015021-pol2qm74 3290 28 trauma trauma NN cord-015021-pol2qm74 3290 29 are be VBP cord-015021-pol2qm74 3290 30 determined determine VBN cord-015021-pol2qm74 3290 31 ( ( -LRB- cord-015021-pol2qm74 3290 32 by by IN cord-015021-pol2qm74 3290 33 hioassays hioassay NNS cord-015021-pol2qm74 3290 34 and and CC cord-015021-pol2qm74 3290 35 respective respective JJ cord-015021-pol2qm74 3290 36 anti anti JJ cord-015021-pol2qm74 3290 37 - - JJ cord-015021-pol2qm74 3290 38 cytokine cytokine JJ cord-015021-pol2qm74 3290 39 antibodies antibody NNS cord-015021-pol2qm74 3290 40 ) ) -RRB- cord-015021-pol2qm74 3290 41 in in IN cord-015021-pol2qm74 3290 42 mice mouse NNS cord-015021-pol2qm74 3290 43 and and CC cord-015021-pol2qm74 3290 44 rats rat NNS cord-015021-pol2qm74 3290 45 subjected subject VBN cord-015021-pol2qm74 3290 46 to to TO cord-015021-pol2qm74 3290 47 scald scald VB cord-015021-pol2qm74 3290 48 injury injury NN cord-015021-pol2qm74 3290 49 ion ion NN cord-015021-pol2qm74 3290 50 C,10 C,10 NNP cord-015021-pol2qm74 3290 51 see see VB cord-015021-pol2qm74 3290 52 , , , cord-015021-pol2qm74 3290 53 ° ° NN cord-015021-pol2qm74 3290 54 0v 0v NN cord-015021-pol2qm74 3290 55 BSA BSA NNP cord-015021-pol2qm74 3290 56 , , , cord-015021-pol2qm74 3290 57 LD LD NNP cord-015021-pol2qm74 3290 58 50 50 CD cord-015021-pol2qm74 3290 59 ) ) -RRB- cord-015021-pol2qm74 3290 60 and and CC cord-015021-pol2qm74 3290 61 ( ( -LRB- cord-015021-pol2qm74 3290 62 80 80 CD cord-015021-pol2qm74 3290 63 C C NNP cord-015021-pol2qm74 3290 64 , , , cord-015021-pol2qm74 3290 65 30 30 CD cord-015021-pol2qm74 3290 66 see see VB cord-015021-pol2qm74 3290 67 , , , cord-015021-pol2qm74 3290 68 20 20 CD cord-015021-pol2qm74 3290 69 ~ ~ NFP cord-015021-pol2qm74 3291 1 B B NNP cord-015021-pol2qm74 3291 2 ~^)~ ~^)~ NNP cord-015021-pol2qm74 3291 3 , , , cord-015021-pol2qm74 3291 4 respectively respectively RB cord-015021-pol2qm74 3291 5 . . . cord-015021-pol2qm74 3292 1 Biphasic Biphasic NNP cord-015021-pol2qm74 3292 2 increase increase NN cord-015021-pol2qm74 3292 3 of of IN cord-015021-pol2qm74 3292 4 cytokine cytokine NN cord-015021-pol2qm74 3292 5 activity activity NN cord-015021-pol2qm74 3292 6 was be VBD cord-015021-pol2qm74 3292 7 noted note VBN cord-015021-pol2qm74 3292 8 in in IN cord-015021-pol2qm74 3292 9 mice mouse NNS cord-015021-pol2qm74 3292 10 : : : cord-015021-pol2qm74 3292 11 initial initial JJ cord-015021-pol2qm74 3292 12 increase increase NN cord-015021-pol2qm74 3292 13 of of IN cord-015021-pol2qm74 3292 14 IL IL NNP cord-015021-pol2qm74 3292 15 - - : cord-015021-pol2qm74 3292 16 I I NNP cord-015021-pol2qm74 3292 17 and and CC cord-015021-pol2qm74 3292 18 IL-6 IL-6 NNP cord-015021-pol2qm74 3292 19 , , , cord-015021-pol2qm74 3292 20 1 1 CD cord-015021-pol2qm74 3292 21 - - SYM cord-015021-pol2qm74 3292 22 3 3 CD cord-015021-pol2qm74 3292 23 hr hr NN cord-015021-pol2qm74 3292 24 following follow VBG cord-015021-pol2qm74 3292 25 injury injury NN cord-015021-pol2qm74 3292 26 and and CC cord-015021-pol2qm74 3292 27 of of IN cord-015021-pol2qm74 3292 28 TRY try NN cord-015021-pol2qm74 3292 29 activity activity NN cord-015021-pol2qm74 3292 30 6hr 6hr NN cord-015021-pol2qm74 3292 31 after after IN cord-015021-pol2qm74 3292 32 scald scald NN cord-015021-pol2qm74 3292 33 , , , cord-015021-pol2qm74 3292 34 followed follow VBN cord-015021-pol2qm74 3292 35 by by IN cord-015021-pol2qm74 3292 36 elevated elevated JJ cord-015021-pol2qm74 3292 37 levels level NNS cord-015021-pol2qm74 3292 38 of of IN cord-015021-pol2qm74 3292 39 IL IL NNP cord-015021-pol2qm74 3292 40 - - : cord-015021-pol2qm74 3292 41 I I NNP cord-015021-pol2qm74 3292 42 and and CC cord-015021-pol2qm74 3292 43 IL-6 IL-6 NNP cord-015021-pol2qm74 3292 44 at at IN cord-015021-pol2qm74 3292 45 12hr 12hr NNP cord-015021-pol2qm74 3292 46 , , , cord-015021-pol2qm74 3292 47 with with IN cord-015021-pol2qm74 3292 48 tendency tendency NN cord-015021-pol2qm74 3292 49 of of IN cord-015021-pol2qm74 3292 50 decrease decrease NN cord-015021-pol2qm74 3292 51 of of IN cord-015021-pol2qm74 3292 52 activity activity NN cord-015021-pol2qm74 3292 53 at at IN cord-015021-pol2qm74 3292 54 later later JJ cord-015021-pol2qm74 3292 55 time time NN cord-015021-pol2qm74 3292 56 points point NNS cord-015021-pol2qm74 3292 57 . . . cord-015021-pol2qm74 3293 1 Increased increase VBN cord-015021-pol2qm74 3293 2 activity activity NN cord-015021-pol2qm74 3293 3 of of IN cord-015021-pol2qm74 3293 4 TNF TNF NNP cord-015021-pol2qm74 3293 5 was be VBD cord-015021-pol2qm74 3293 6 noted note VBN cord-015021-pol2qm74 3293 7 24 24 CD cord-015021-pol2qm74 3293 8 hr hr NN cord-015021-pol2qm74 3293 9 following follow VBG cord-015021-pol2qm74 3293 10 injury injury NN cord-015021-pol2qm74 3293 11 , , , cord-015021-pol2qm74 3294 1 In in IN cord-015021-pol2qm74 3294 2 rats rat NNS cord-015021-pol2qm74 3294 3 , , , cord-015021-pol2qm74 3294 4 initial initial JJ cord-015021-pol2qm74 3294 5 , , , cord-015021-pol2qm74 3294 6 short short RB cord-015021-pol2qm74 3294 7 - - HYPH cord-015021-pol2qm74 3294 8 lived live VBN cord-015021-pol2qm74 3294 9 increase increase NN cord-015021-pol2qm74 3294 10 of of IN cord-015021-pol2qm74 3294 11 IL IL NNP cord-015021-pol2qm74 3294 12 - - HYPH cord-015021-pol2qm74 3294 13 i i NNP cord-015021-pol2qm74 3294 14 and and CC cord-015021-pol2qm74 3294 15 TNF TNF NNP cord-015021-pol2qm74 3294 16 activity activity NN cord-015021-pol2qm74 3294 17 was be VBD cord-015021-pol2qm74 3294 18 detected detect VBN cord-015021-pol2qm74 3294 19 lhr lhr NNP cord-015021-pol2qm74 3294 20 following follow VBG cord-015021-pol2qm74 3294 21 injury injury NN cord-015021-pol2qm74 3294 22 , , , cord-015021-pol2qm74 3294 23 folowed folowe VBN cord-015021-pol2qm74 3294 24 by by IN cord-015021-pol2qm74 3294 25 increase increase NN cord-015021-pol2qm74 3294 26 on on IN cord-015021-pol2qm74 3294 27 days day NNS cord-015021-pol2qm74 3294 28 I -PRON- PRP cord-015021-pol2qm74 3294 29 and and CC cord-015021-pol2qm74 3294 30 3 3 CD cord-015021-pol2qm74 3294 31 postburn postburn NN cord-015021-pol2qm74 3294 32 . . . cord-015021-pol2qm74 3295 1 IL-6 IL-6 NNP cord-015021-pol2qm74 3295 2 increase increase NN cord-015021-pol2qm74 3295 3 peaked peak VBD cord-015021-pol2qm74 3295 4 3 3 CD cord-015021-pol2qm74 3295 5 - - SYM cord-015021-pol2qm74 3295 6 12 12 CD cord-015021-pol2qm74 3295 7 hr hr NN cord-015021-pol2qm74 3295 8 after after IN cord-015021-pol2qm74 3295 9 scalding scald VBG cord-015021-pol2qm74 3295 10 and and CC cord-015021-pol2qm74 3295 11 levels level NNS cord-015021-pol2qm74 3295 12 remained remain VBD cord-015021-pol2qm74 3295 13 elevated elevated JJ cord-015021-pol2qm74 3295 14 3 3 CD cord-015021-pol2qm74 3295 15 - - SYM cord-015021-pol2qm74 3295 16 5 5 CD cord-015021-pol2qm74 3295 17 days day NNS cord-015021-pol2qm74 3295 18 following follow VBG cord-015021-pol2qm74 3295 19 injury injury NN cord-015021-pol2qm74 3295 20 . . . cord-015021-pol2qm74 3296 1 Similar similar JJ cord-015021-pol2qm74 3296 2 kinetics kinetic NNS cord-015021-pol2qm74 3296 3 of of IN cord-015021-pol2qm74 3296 4 appearance appearance NN cord-015021-pol2qm74 3296 5 of of IN cord-015021-pol2qm74 3296 6 proinflammatory proinflammatory JJ cord-015021-pol2qm74 3296 7 cytokines cytokine NNS cord-015021-pol2qm74 3296 8 ( ( -LRB- cord-015021-pol2qm74 3296 9 IL IL NNP cord-015021-pol2qm74 3296 10 - - HYPH cord-015021-pol2qm74 3296 11 I I NNP cord-015021-pol2qm74 3296 12 and and CC cord-015021-pol2qm74 3296 13 TNF TNF NNP cord-015021-pol2qm74 3296 14 - - HYPH cord-015021-pol2qm74 3296 15 alpha alpha NN cord-015021-pol2qm74 3296 16 ) ) -RRB- cord-015021-pol2qm74 3296 17 both both CC cord-015021-pol2qm74 3296 18 in in IN cord-015021-pol2qm74 3296 19 lethal lethal JJ cord-015021-pol2qm74 3296 20 and and CC cord-015021-pol2qm74 3296 21 ncnlethal ncnlethal JJ cord-015021-pol2qm74 3296 22 injury injury NN cord-015021-pol2qm74 3296 23 concomitant concomitant JJ cord-015021-pol2qm74 3296 24 with with IN cord-015021-pol2qm74 3296 25 differential differential JJ cord-015021-pol2qm74 3296 26 profile profile NN cord-015021-pol2qm74 3296 27 of of IN cord-015021-pol2qm74 3296 28 circulating circulate VBG cord-015021-pol2qm74 3296 29 IL-6 IL-6 NNP cord-015021-pol2qm74 3296 30 activity activity NN cord-015021-pol2qm74 3296 31 ( ( -LRB- cord-015021-pol2qm74 3296 32 early early JJ cord-015021-pol2qm74 3296 33 , , , cord-015021-pol2qm74 3296 34 short short RB cord-015021-pol2qm74 3296 35 - - HYPH cord-015021-pol2qm74 3296 36 lived live VBN cord-015021-pol2qm74 3296 37 increase increase NN cord-015021-pol2qm74 3296 38 and and CC cord-015021-pol2qm74 3296 39 later later RBR cord-015021-pol2qm74 3296 40 slow slow JJ cord-015021-pol2qm74 3296 41 decrease decrease NN cord-015021-pol2qm74 3296 42 of of IN cord-015021-pol2qm74 3296 43 activity activity NN cord-015021-pol2qm74 3296 44 in in IN cord-015021-pol2qm74 3296 45 lethal lethal JJ cord-015021-pol2qm74 3296 46 burn burn NN cord-015021-pol2qm74 3296 47 injury injury NN cord-015021-pol2qm74 3296 48 ) ) -RRB- cord-015021-pol2qm74 3296 49 with with IN cord-015021-pol2qm74 3296 50 late late JJ cord-015021-pol2qm74 3296 51 persistent persistent JJ cord-015021-pol2qm74 3296 52 high high JJ cord-015021-pol2qm74 3296 53 levels level NNS cord-015021-pol2qm74 3296 54 of of IN cord-015021-pol2qm74 3296 55 activity activity NN cord-015021-pol2qm74 3296 56 in in IN cord-015021-pol2qm74 3296 57 nonlethai nonlethai NNP cord-015021-pol2qm74 3296 58 injury injury NN cord-015021-pol2qm74 3296 59 demonstrated demonstrate VBN cord-015021-pol2qm74 3296 60 in in IN cord-015021-pol2qm74 3296 61 the the DT cord-015021-pol2qm74 3296 62 present present JJ cord-015021-pol2qm74 3296 63 study study NN cord-015021-pol2qm74 3296 64 highlight highlight VBP cord-015021-pol2qm74 3296 65 the the DT cord-015021-pol2qm74 3296 66 need need NN cord-015021-pol2qm74 3296 67 for for IN cord-015021-pol2qm74 3296 68 investigation investigation NN cord-015021-pol2qm74 3296 69 the the DT cord-015021-pol2qm74 3296 70 relationship relationship NN cord-015021-pol2qm74 3296 71 of of IN cord-015021-pol2qm74 3296 72 these these DT cord-015021-pol2qm74 3296 73 cytokines cytokine NNS cord-015021-pol2qm74 3296 74 in in IN cord-015021-pol2qm74 3296 75 burn burn NN cord-015021-pol2qm74 3296 76 - - HYPH cord-015021-pol2qm74 3296 77 injury injury NN cord-015021-pol2qm74 3296 78 induced induce VBN cord-015021-pol2qm74 3296 79 inflammation inflammation NN cord-015021-pol2qm74 3296 80 . . . cord-015021-pol2qm74 3297 1 Zikica Zikica NNP cord-015021-pol2qm74 3297 2 Jovicic Jovicic NNP cord-015021-pol2qm74 3297 3 , , , cord-015021-pol2qm74 3297 4 lnstitute lnstitute NN cord-015021-pol2qm74 3297 5 for for IN cord-015021-pol2qm74 3297 6 Medical Medical NNP cord-015021-pol2qm74 3297 7 Research Research NNP cord-015021-pol2qm74 3297 8 , , , cord-015021-pol2qm74 3297 9 MMA MMA NNP cord-015021-pol2qm74 3297 10 , , , cord-015021-pol2qm74 3297 11 Crnotravska Crnotravska NNP cord-015021-pol2qm74 3297 12 17,11002 17,11002 CD cord-015021-pol2qm74 3297 13 Belgrade Belgrade NNP cord-015021-pol2qm74 3297 14 ~ ~ NFP cord-015021-pol2qm74 3297 15 Yu Yu NNP cord-015021-pol2qm74 3297 16 . . . cord-015021-pol2qm74 3298 1 Asadullah Asadullah NNP cord-015021-pol2qm74 3298 2 K K NNP cord-015021-pol2qm74 3298 3 ( ( -LRB- cord-015021-pol2qm74 3298 4 1 1 CD cord-015021-pol2qm74 3298 5 ) ) -RRB- cord-015021-pol2qm74 3298 6 , , , cord-015021-pol2qm74 3298 7 Woiciechowsky Woiciechowsky NNP cord-015021-pol2qm74 3298 8 C C NNP cord-015021-pol2qm74 3298 9 ( ( -LRB- cord-015021-pol2qm74 3298 10 2 2 CD cord-015021-pol2qm74 3298 11 ) ) -RRB- cord-015021-pol2qm74 3298 12 , , , cord-015021-pol2qm74 3298 13 LiebenthaI liebenthai FW cord-015021-pol2qm74 3298 14 C C NNP cord-015021-pol2qm74 3298 15 ( ( -LRB- cord-015021-pol2qm74 3298 16 1 1 CD cord-015021-pol2qm74 3298 17 ) ) -RRB- cord-015021-pol2qm74 3298 18 , , , cord-015021-pol2qm74 3298 19 Doecke Doecke NNP cord-015021-pol2qm74 3298 20 WD WD NNP cord-015021-pol2qm74 3298 21 ( ( -LRB- cord-015021-pol2qm74 3298 22 1 1 CD cord-015021-pol2qm74 3298 23 ) ) -RRB- cord-015021-pol2qm74 3298 24 , , , cord-015021-pol2qm74 3298 25 Volk Volk NNP cord-015021-pol2qm74 3298 26 HD HD NNP cord-015021-pol2qm74 3298 27 ( ( -LRB- cord-015021-pol2qm74 3298 28 1 1 CD cord-015021-pol2qm74 3298 29 ) ) -RRB- cord-015021-pol2qm74 3298 30 , , , cord-015021-pol2qm74 3298 31 Vogel Vogel NNP cord-015021-pol2qm74 3298 32 S S NNP cord-015021-pol2qm74 3298 33 ( ( -LRB- cord-015021-pol2qm74 3298 34 2 2 CD cord-015021-pol2qm74 3298 35 ) ) -RRB- cord-015021-pol2qm74 3298 36 , , , cord-015021-pol2qm74 3298 37 v. v. CC cord-015021-pol2qm74 3298 38 Baehr Baehr NNP cord-015021-pol2qm74 3298 39 R R NNP cord-015021-pol2qm74 3298 40 ( ( -LRB- cord-015021-pol2qm74 3298 41 1 1 CD cord-015021-pol2qm74 3298 42 ) ) -RRB- cord-015021-pol2qm74 3298 43 ; ; : cord-015021-pol2qm74 3298 44 Depts Depts NNPS cord-015021-pol2qm74 3298 45 . . . cord-015021-pol2qm74 3299 1 of of IN cord-015021-pol2qm74 3299 2 Med Med NNP cord-015021-pol2qm74 3299 3 . . . cord-015021-pol2qm74 3299 4 Immunology Immunology NNP cord-015021-pol2qm74 3299 5 ( ( -LRB- cord-015021-pol2qm74 3299 6 1 1 CD cord-015021-pol2qm74 3299 7 ) ) -RRB- cord-015021-pol2qm74 3299 8 and and CC cord-015021-pol2qm74 3299 9 Neurosurgery Neurosurgery NNP cord-015021-pol2qm74 3299 10 ( ( -LRB- cord-015021-pol2qm74 3299 11 2 2 CD cord-015021-pol2qm74 3299 12 ) ) -RRB- cord-015021-pol2qm74 3299 13 , , , cord-015021-pol2qm74 3299 14 Medical Medical NNP cord-015021-pol2qm74 3299 15 School School NNP cord-015021-pol2qm74 3299 16 ( ( -LRB- cord-015021-pol2qm74 3299 17 Char#d Char#d NNP cord-015021-pol2qm74 3299 18 ) ) -RRB- cord-015021-pol2qm74 3299 19 , , , cord-015021-pol2qm74 3299 20 Humboldt Humboldt NNP cord-015021-pol2qm74 3299 21 University University NNP cord-015021-pol2qm74 3299 22 Berlin Berlin NNP cord-015021-pol2qm74 3299 23 , , , cord-015021-pol2qm74 3299 24 FRG FRG NNP cord-015021-pol2qm74 3300 1 In in IN cord-015021-pol2qm74 3300 2 patients patient NNS cord-015021-pol2qm74 3300 3 after after IN cord-015021-pol2qm74 3300 4 polytrauma polytrauma NN cord-015021-pol2qm74 3300 5 or or CC cord-015021-pol2qm74 3300 6 major major JJ cord-015021-pol2qm74 3300 7 abdominal abdominal JJ cord-015021-pol2qm74 3300 8 surgery surgery NN cord-015021-pol2qm74 3300 9 a a DT cord-015021-pol2qm74 3300 10 hyperinflammatory hyperinflammatory JJ cord-015021-pol2qm74 3300 11 phase phase NN cord-015021-pol2qm74 3300 12 seems seem VBZ cord-015021-pol2qm74 3300 13 to to TO cord-015021-pol2qm74 3300 14 be be VB cord-015021-pol2qm74 3300 15 followed follow VBN cord-015021-pol2qm74 3300 16 by by IN cord-015021-pol2qm74 3300 17 the the DT cord-015021-pol2qm74 3300 18 development development NN cord-015021-pol2qm74 3300 19 of of IN cord-015021-pol2qm74 3300 20 a a DT cord-015021-pol2qm74 3300 21 phase phase NN cord-015021-pol2qm74 3300 22 of of IN cord-015021-pol2qm74 3300 23 monocyte monocyte NNP cord-015021-pol2qm74 3300 24 inactivation inactivation NN cord-015021-pol2qm74 3300 25 . . . cord-015021-pol2qm74 3301 1 The the DT cord-015021-pol2qm74 3301 2 latter latter JJ cord-015021-pol2qm74 3301 3 is be VBZ cord-015021-pol2qm74 3301 4 charaeterised charaeterise VBN cord-015021-pol2qm74 3301 5 by by IN cord-015021-pol2qm74 3301 6 a a DT cord-015021-pol2qm74 3301 7 decrease decrease NN cord-015021-pol2qm74 3301 8 of of IN cord-015021-pol2qm74 3301 9 monocytic monocytic JJ cord-015021-pol2qm74 3301 10 HLA HLA NNP cord-015021-pol2qm74 3301 11 - - HYPH cord-015021-pol2qm74 3301 12 DR DR NNP cord-015021-pol2qm74 3301 13 expression expression NN cord-015021-pol2qm74 3301 14 and and CC cord-015021-pol2qm74 3301 15 a a DT cord-015021-pol2qm74 3301 16 shift shift NN cord-015021-pol2qm74 3301 17 to to IN cord-015021-pol2qm74 3301 18 anti anti JJ cord-015021-pol2qm74 3301 19 - - JJ cord-015021-pol2qm74 3301 20 inflammatory inflammatory JJ cord-015021-pol2qm74 3301 21 cytokine cytokine NN cord-015021-pol2qm74 3301 22 production production NN cord-015021-pol2qm74 3301 23 . . . cord-015021-pol2qm74 3302 1 As as IN cord-015021-pol2qm74 3302 2 shown show VBN cord-015021-pol2qm74 3302 3 , , , cord-015021-pol2qm74 3302 4 by by IN cord-015021-pol2qm74 3302 5 us -PRON- PRP cord-015021-pol2qm74 3302 6 and and CC cord-015021-pol2qm74 3302 7 others other NNS cord-015021-pol2qm74 3302 8 , , , cord-015021-pol2qm74 3302 9 this this DT cord-015021-pol2qm74 3302 10 phenomenon phenomenon NN cord-015021-pol2qm74 3302 11 indicates indicate VBZ cord-015021-pol2qm74 3302 12 severe severe JJ cord-015021-pol2qm74 3302 13 immunodepression immunodepression NN cord-015021-pol2qm74 3302 14 with with IN cord-015021-pol2qm74 3302 15 a a DT cord-015021-pol2qm74 3302 16 high high JJ cord-015021-pol2qm74 3302 17 risk risk NN cord-015021-pol2qm74 3302 18 of of IN cord-015021-pol2qm74 3302 19 infection infection NN cord-015021-pol2qm74 3302 20 . . . cord-015021-pol2qm74 3303 1 However however RB cord-015021-pol2qm74 3303 2 , , , cord-015021-pol2qm74 3303 3 the the DT cord-015021-pol2qm74 3303 4 mechanisms mechanism NNS cord-015021-pol2qm74 3303 5 leading lead VBG cord-015021-pol2qm74 3303 6 to to IN cord-015021-pol2qm74 3303 7 monocyte monocyte NNP cord-015021-pol2qm74 3303 8 inactivation inactivation NN cord-015021-pol2qm74 3303 9 in in IN cord-015021-pol2qm74 3303 10 the the DT cord-015021-pol2qm74 3303 11 above above RB cord-015021-pol2qm74 3303 12 mentioned mention VBN cord-015021-pol2qm74 3303 13 syndromes syndrome NNS cord-015021-pol2qm74 3303 14 may may MD cord-015021-pol2qm74 3303 15 be be VB cord-015021-pol2qm74 3303 16 multiple multiple JJ cord-015021-pol2qm74 3303 17 . . . cord-015021-pol2qm74 3304 1 To to TO cord-015021-pol2qm74 3304 2 elucidate elucidate VB cord-015021-pol2qm74 3304 3 the the DT cord-015021-pol2qm74 3304 4 influence influence NN cord-015021-pol2qm74 3304 5 of of IN cord-015021-pol2qm74 3304 6 a a DT cord-015021-pol2qm74 3304 7 selective selective JJ cord-015021-pol2qm74 3304 8 , , , cord-015021-pol2qm74 3304 9 sterile sterile JJ cord-015021-pol2qm74 3304 10 trauma trauma NN cord-015021-pol2qm74 3304 11 to to IN cord-015021-pol2qm74 3304 12 the the DT cord-015021-pol2qm74 3304 13 central central JJ cord-015021-pol2qm74 3304 14 nervous nervous JJ cord-015021-pol2qm74 3304 15 system system NN cord-015021-pol2qm74 3304 16 ( ( -LRB- cord-015021-pol2qm74 3304 17 CNS CNS NNP cord-015021-pol2qm74 3304 18 ) ) -RRB- cord-015021-pol2qm74 3304 19 on on IN cord-015021-pol2qm74 3304 20 immune immune JJ cord-015021-pol2qm74 3304 21 reactivity reactivity NN cord-015021-pol2qm74 3304 22 the the DT cord-015021-pol2qm74 3304 23 neurosurgieal neurosurgieal NN cord-015021-pol2qm74 3304 24 patient patient NN cord-015021-pol2qm74 3304 25 is be VBZ cord-015021-pol2qm74 3304 26 an an DT cord-015021-pol2qm74 3304 27 interesting interesting JJ cord-015021-pol2qm74 3304 28 model model NN cord-015021-pol2qm74 3304 29 . . . cord-015021-pol2qm74 3305 1 Initially initially RB cord-015021-pol2qm74 3305 2 , , , cord-015021-pol2qm74 3305 3 30 30 CD cord-015021-pol2qm74 3305 4 patients patient NNS cord-015021-pol2qm74 3305 5 who who WP cord-015021-pol2qm74 3305 6 developed develop VBD cord-015021-pol2qm74 3305 7 a a DT cord-015021-pol2qm74 3305 8 systemic systemic JJ cord-015021-pol2qm74 3305 9 inflammatory inflammatory JJ cord-015021-pol2qm74 3305 10 response response NN cord-015021-pol2qm74 3305 11 syndrome syndrome NN cord-015021-pol2qm74 3305 12 following follow VBG cord-015021-pol2qm74 3305 13 neurosurgery neurosurgery NNP cord-015021-pol2qm74 3305 14 were be VBD cord-015021-pol2qm74 3305 15 analysed analyse VBN cord-015021-pol2qm74 3305 16 . . . cord-015021-pol2qm74 3306 1 In in IN cord-015021-pol2qm74 3306 2 all all DT cord-015021-pol2qm74 3306 3 of of IN cord-015021-pol2qm74 3306 4 them -PRON- PRP cord-015021-pol2qm74 3306 5 a a DT cord-015021-pol2qm74 3306 6 marked marked JJ cord-015021-pol2qm74 3306 7 decrease decrease NN cord-015021-pol2qm74 3306 8 of of IN cord-015021-pol2qm74 3306 9 monocytic monocytic JJ cord-015021-pol2qm74 3306 10 HLA HLA NNP cord-015021-pol2qm74 3306 11 - - HYPH cord-015021-pol2qm74 3306 12 DR DR NNP cord-015021-pol2qm74 3306 13 expression expression NN cord-015021-pol2qm74 3306 14 was be VBD cord-015021-pol2qm74 3306 15 observed observe VBN cord-015021-pol2qm74 3306 16 soon soon RB cord-015021-pol2qm74 3306 17 after after IN cord-015021-pol2qm74 3306 18 the the DT cord-015021-pol2qm74 3306 19 operation operation NN cord-015021-pol2qm74 3306 20 . . . cord-015021-pol2qm74 3307 1 These these DT cord-015021-pol2qm74 3307 2 results result NNS cord-015021-pol2qm74 3307 3 suggest suggest VBP cord-015021-pol2qm74 3307 4 that that IN cord-015021-pol2qm74 3307 5 neurosurgery neurosurgery NN cord-015021-pol2qm74 3307 6 alone alone RB cord-015021-pol2qm74 3307 7 can can MD cord-015021-pol2qm74 3307 8 induce induce VB cord-015021-pol2qm74 3307 9 immunodepression immunodepression NN cord-015021-pol2qm74 3307 10 and and CC cord-015021-pol2qm74 3307 11 lead lead VB cord-015021-pol2qm74 3307 12 us -PRON- PRP cord-015021-pol2qm74 3307 13 to to TO cord-015021-pol2qm74 3307 14 conduct conduct VB cord-015021-pol2qm74 3307 15 a a DT cord-015021-pol2qm74 3307 16 prospective prospective JJ cord-015021-pol2qm74 3307 17 study study NN cord-015021-pol2qm74 3307 18 , , , cord-015021-pol2qm74 3307 19 in in IN cord-015021-pol2qm74 3307 20 which which WDT cord-015021-pol2qm74 3307 21 we -PRON- PRP cord-015021-pol2qm74 3307 22 closely closely RB cord-015021-pol2qm74 3307 23 monitored monitor VBD cord-015021-pol2qm74 3307 24 l0 l0 NNP cord-015021-pol2qm74 3307 25 patients patient NNS cord-015021-pol2qm74 3307 26 undergoing undergo VBG cord-015021-pol2qm74 3307 27 neurosurgery neurosurgery NN cord-015021-pol2qm74 3307 28 from from IN cord-015021-pol2qm74 3307 29 the the DT cord-015021-pol2qm74 3307 30 first first JJ cord-015021-pol2qm74 3307 31 preoperative preoperative JJ cord-015021-pol2qm74 3307 32 day day NN cord-015021-pol2qm74 3307 33 until until IN cord-015021-pol2qm74 3307 34 at at IN cord-015021-pol2qm74 3307 35 least least JJS cord-015021-pol2qm74 3307 36 day day NN cord-015021-pol2qm74 3307 37 6 6 CD cord-015021-pol2qm74 3307 38 after after IN cord-015021-pol2qm74 3307 39 the the DT cord-015021-pol2qm74 3307 40 operation operation NN cord-015021-pol2qm74 3307 41 . . . cord-015021-pol2qm74 3308 1 HLA HLA NNP cord-015021-pol2qm74 3308 2 - - HYPH cord-015021-pol2qm74 3308 3 DR DR NNP cord-015021-pol2qm74 3308 4 expression expression NN cord-015021-pol2qm74 3308 5 was be VBD cord-015021-pol2qm74 3308 6 decreased decrease VBN cord-015021-pol2qm74 3308 7 hi hi UH cord-015021-pol2qm74 3308 8 all all DT cord-015021-pol2qm74 3308 9 patients patient NNS cord-015021-pol2qm74 3308 10 to to IN cord-015021-pol2qm74 3308 11 various various JJ cord-015021-pol2qm74 3308 12 extent extent NN cord-015021-pol2qm74 3308 13 only only RB cord-015021-pol2qm74 3308 14 hours hour NNS cord-015021-pol2qm74 3308 15 after after IN cord-015021-pol2qm74 3308 16 surgery surgery NN cord-015021-pol2qm74 3308 17 . . . cord-015021-pol2qm74 3309 1 In in IN cord-015021-pol2qm74 3309 2 one one CD cord-015021-pol2qm74 3309 3 patient patient NN cord-015021-pol2qm74 3309 4 only only RB cord-015021-pol2qm74 3309 5 we -PRON- PRP cord-015021-pol2qm74 3309 6 found find VBD cord-015021-pol2qm74 3309 7 a a DT cord-015021-pol2qm74 3309 8 persistently persistently RB cord-015021-pol2qm74 3309 9 reduced reduce VBN cord-015021-pol2qm74 3309 10 HLA HLA NNP cord-015021-pol2qm74 3309 11 - - HYPH cord-015021-pol2qm74 3309 12 DR DR NNP cord-015021-pol2qm74 3309 13 expression expression NN cord-015021-pol2qm74 3309 14 and and CC cord-015021-pol2qm74 3309 15 this this DT cord-015021-pol2qm74 3309 16 was be VBD cord-015021-pol2qm74 3309 17 the the DT cord-015021-pol2qm74 3309 18 only only JJ cord-015021-pol2qm74 3309 19 patient patient NN cord-015021-pol2qm74 3309 20 to to TO cord-015021-pol2qm74 3309 21 develop develop VB cord-015021-pol2qm74 3309 22 sepsis sepsis NN cord-015021-pol2qm74 3309 23 syndrome syndrome NN cord-015021-pol2qm74 3309 24 . . . cord-015021-pol2qm74 3310 1 This this DT cord-015021-pol2qm74 3310 2 suggests suggest VBZ cord-015021-pol2qm74 3310 3 that that IN cord-015021-pol2qm74 3310 4 a a DT cord-015021-pol2qm74 3310 5 prolonged prolonged JJ cord-015021-pol2qm74 3310 6 , , , cord-015021-pol2qm74 3310 7 postoperatively postoperatively RB cord-015021-pol2qm74 3310 8 decreased decrease VBD cord-015021-pol2qm74 3310 9 HLA HLA NNP cord-015021-pol2qm74 3310 10 - - HYPH cord-015021-pol2qm74 3310 11 DR DR NNP cord-015021-pol2qm74 3310 12 expression expression NN cord-015021-pol2qm74 3310 13 is be VBZ cord-015021-pol2qm74 3310 14 predictive predictive JJ cord-015021-pol2qm74 3310 15 of of IN cord-015021-pol2qm74 3310 16 infection infection NN cord-015021-pol2qm74 3310 17 following follow VBG cord-015021-pol2qm74 3310 18 CNS CNS NNP cord-015021-pol2qm74 3310 19 trauma trauma NN cord-015021-pol2qm74 3310 20 . . . cord-015021-pol2qm74 3311 1 In in IN cord-015021-pol2qm74 3311 2 order order NN cord-015021-pol2qm74 3311 3 to to TO cord-015021-pol2qm74 3311 4 assess assess VB cord-015021-pol2qm74 3311 5 , , , cord-015021-pol2qm74 3311 6 whether whether IN cord-015021-pol2qm74 3311 7 a a DT cord-015021-pol2qm74 3311 8 decrease decrease NN cord-015021-pol2qm74 3311 9 of of IN cord-015021-pol2qm74 3311 10 HLA HLA NNP cord-015021-pol2qm74 3311 11 - - HYPH cord-015021-pol2qm74 3311 12 DR DR NNP cord-015021-pol2qm74 3311 13 expression expression NN cord-015021-pol2qm74 3311 14 was be VBD cord-015021-pol2qm74 3311 15 associated associate VBN cord-015021-pol2qm74 3311 16 with with IN cord-015021-pol2qm74 3311 17 a a DT cord-015021-pol2qm74 3311 18 preceding precede VBG cord-015021-pol2qm74 3311 19 inflammatory inflammatory JJ cord-015021-pol2qm74 3311 20 response response NN cord-015021-pol2qm74 3311 21 , , , cord-015021-pol2qm74 3311 22 local local JJ cord-015021-pol2qm74 3311 23 cytokine cytokine NN cord-015021-pol2qm74 3311 24 release release NN cord-015021-pol2qm74 3311 25 in in IN cord-015021-pol2qm74 3311 26 the the DT cord-015021-pol2qm74 3311 27 CNS CNS NNP cord-015021-pol2qm74 3311 28 was be VBD cord-015021-pol2qm74 3311 29 compared compare VBN cord-015021-pol2qm74 3311 30 with with IN cord-015021-pol2qm74 3311 31 systemic systemic JJ cord-015021-pol2qm74 3311 32 cytokine cytokine NN cord-015021-pol2qm74 3311 33 release release NN cord-015021-pol2qm74 3311 34 . . . cord-015021-pol2qm74 3312 1 For for IN cord-015021-pol2qm74 3312 2 this this DT cord-015021-pol2qm74 3312 3 purpose purpose NN cord-015021-pol2qm74 3312 4 , , , cord-015021-pol2qm74 3312 5 paired pair VBD cord-015021-pol2qm74 3312 6 samples sample NNS cord-015021-pol2qm74 3312 7 of of IN cord-015021-pol2qm74 3312 8 earebrospinal earebrospinal JJ cord-015021-pol2qm74 3312 9 fluid fluid NN cord-015021-pol2qm74 3312 10 ( ( -LRB- cord-015021-pol2qm74 3312 11 CSF CSF NNP cord-015021-pol2qm74 3312 12 ) ) -RRB- cord-015021-pol2qm74 3312 13 from from IN cord-015021-pol2qm74 3312 14 a a DT cord-015021-pol2qm74 3312 15 vantricle vantricle NN cord-015021-pol2qm74 3312 16 drainage drainage NN cord-015021-pol2qm74 3312 17 and and CC cord-015021-pol2qm74 3312 18 peripheral peripheral JJ cord-015021-pol2qm74 3312 19 blood blood NN cord-015021-pol2qm74 3312 20 plasma plasma NN cord-015021-pol2qm74 3312 21 were be VBD cord-015021-pol2qm74 3312 22 obtained obtain VBN cord-015021-pol2qm74 3312 23 . . . cord-015021-pol2qm74 3313 1 In in IN cord-015021-pol2qm74 3313 2 the the DT cord-015021-pol2qm74 3313 3 CSF CSF NNP cord-015021-pol2qm74 3313 4 extremely extremely RB cord-015021-pol2qm74 3313 5 elevated elevate VBN cord-015021-pol2qm74 3313 6 futerleakin futerleakin NN cord-015021-pol2qm74 3313 7 ( ( -LRB- cord-015021-pol2qm74 3313 8 IL)-6 IL)-6 NNP cord-015021-pol2qm74 3313 9 levels level NNS cord-015021-pol2qm74 3313 10 , , , cord-015021-pol2qm74 3313 11 peaking peak VBG cord-015021-pol2qm74 3313 12 already already RB cord-015021-pol2qm74 3313 13 a a DT cord-015021-pol2qm74 3313 14 few few JJ cord-015021-pol2qm74 3313 15 hours hour NNS cord-015021-pol2qm74 3313 16 after after IN cord-015021-pol2qm74 3313 17 the the DT cord-015021-pol2qm74 3313 18 operation operation NN cord-015021-pol2qm74 3313 19 were be VBD cord-015021-pol2qm74 3313 20 found find VBN cord-015021-pol2qm74 3313 21 . . . cord-015021-pol2qm74 3314 1 In in IN cord-015021-pol2qm74 3314 2 plasma plasma NN cord-015021-pol2qm74 3314 3 , , , cord-015021-pol2qm74 3314 4 by by IN cord-015021-pol2qm74 3314 5 eontrast eontrast NNP cord-015021-pol2qm74 3314 6 , , , cord-015021-pol2qm74 3314 7 IL-6 IL-6 NNP cord-015021-pol2qm74 3314 8 ( ( -LRB- cord-015021-pol2qm74 3314 9 and and CC cord-015021-pol2qm74 3314 10 TNF tnf NN cord-015021-pol2qm74 3314 11 - - HYPH cord-015021-pol2qm74 3314 12 alpha alpha NN cord-015021-pol2qm74 3314 13 ) ) -RRB- cord-015021-pol2qm74 3314 14 was be VBD cord-015021-pol2qm74 3314 15 detectable detectable JJ cord-015021-pol2qm74 3314 16 not not RB cord-015021-pol2qm74 3314 17 until until IN cord-015021-pol2qm74 3314 18 days day NNS cord-015021-pol2qm74 3314 19 later later RB cord-015021-pol2qm74 3314 20 and and CC cord-015021-pol2qm74 3314 21 only only RB cord-015021-pol2qm74 3314 22 if if IN cord-015021-pol2qm74 3314 23 infection infection NN cord-015021-pol2qm74 3314 24 was be VBD cord-015021-pol2qm74 3314 25 present present JJ cord-015021-pol2qm74 3314 26 . . . cord-015021-pol2qm74 3315 1 The the DT cord-015021-pol2qm74 3315 2 antiinflammatory antiinflammatory JJ cord-015021-pol2qm74 3315 3 ILI ILI NNP cord-015021-pol2qm74 3315 4 - - HYPH cord-015021-pol2qm74 3315 5 RA RA NNP cord-015021-pol2qm74 3315 6 , , , cord-015021-pol2qm74 3315 7 on on IN cord-015021-pol2qm74 3315 8 the the DT cord-015021-pol2qm74 3315 9 other other JJ cord-015021-pol2qm74 3315 10 hand hand NN cord-015021-pol2qm74 3315 11 , , , cord-015021-pol2qm74 3315 12 was be VBD cord-015021-pol2qm74 3315 13 also also RB cord-015021-pol2qm74 3315 14 present present JJ cord-015021-pol2qm74 3315 15 in in IN cord-015021-pol2qm74 3315 16 CSF CSF NNP cord-015021-pol2qm74 3315 17 but but CC cord-015021-pol2qm74 3315 18 peaked peak VBD cord-015021-pol2qm74 3315 19 after after IN cord-015021-pol2qm74 3315 20 IL-6 IL-6 NNP cord-015021-pol2qm74 3315 21 and and CC cord-015021-pol2qm74 3315 22 was be VBD cord-015021-pol2qm74 3315 23 detectable detectable JJ cord-015021-pol2qm74 3315 24 in in IN cord-015021-pol2qm74 3315 25 peripheral peripheral JJ cord-015021-pol2qm74 3315 26 plasma plasma NN cord-015021-pol2qm74 3315 27 too too RB cord-015021-pol2qm74 3315 28 . . . cord-015021-pol2qm74 3316 1 We -PRON- PRP cord-015021-pol2qm74 3316 2 believe believe VBP cord-015021-pol2qm74 3316 3 there there EX cord-015021-pol2qm74 3316 4 is be VBZ cord-015021-pol2qm74 3316 5 an an DT cord-015021-pol2qm74 3316 6 association association NN cord-015021-pol2qm74 3316 7 between between IN cord-015021-pol2qm74 3316 8 the the DT cord-015021-pol2qm74 3316 9 inflammatory inflammatory JJ cord-015021-pol2qm74 3316 10 response response NN cord-015021-pol2qm74 3316 11 in in IN cord-015021-pol2qm74 3316 12 the the DT cord-015021-pol2qm74 3316 13 CNS CNS NNP cord-015021-pol2qm74 3316 14 and and CC cord-015021-pol2qm74 3316 15 the the DT cord-015021-pol2qm74 3316 16 following follow VBG cord-015021-pol2qm74 3316 17 depression depression NN cord-015021-pol2qm74 3316 18 of of IN cord-015021-pol2qm74 3316 19 HLA HLA NNP cord-015021-pol2qm74 3316 20 - - HYPH cord-015021-pol2qm74 3316 21 DR DR NNP cord-015021-pol2qm74 3316 22 expression expression NN cord-015021-pol2qm74 3316 23 on on IN cord-015021-pol2qm74 3316 24 peripheral peripheral JJ cord-015021-pol2qm74 3316 25 blood blood NN cord-015021-pol2qm74 3316 26 monocytes monocyte NNS cord-015021-pol2qm74 3316 27 . . . cord-015021-pol2qm74 3317 1 Our -PRON- PRP$ cord-015021-pol2qm74 3317 2 results result NNS cord-015021-pol2qm74 3317 3 suggest suggest VBP cord-015021-pol2qm74 3317 4 that that IN cord-015021-pol2qm74 3317 5 even even RB cord-015021-pol2qm74 3317 6 a a DT cord-015021-pol2qm74 3317 7 sterile sterile JJ cord-015021-pol2qm74 3317 8 CNS CNS NNP cord-015021-pol2qm74 3317 9 - - HYPH cord-015021-pol2qm74 3317 10 trauma trauma NN cord-015021-pol2qm74 3317 11 by by IN cord-015021-pol2qm74 3317 12 itself -PRON- PRP cord-015021-pol2qm74 3317 13 may may MD cord-015021-pol2qm74 3317 14 contribute contribute VB cord-015021-pol2qm74 3317 15 to to IN cord-015021-pol2qm74 3317 16 general general NNP cord-015021-pol2qm74 3317 17 immunodepressinn immunodepressinn NNP cord-015021-pol2qm74 3317 18 leading lead VBG cord-015021-pol2qm74 3317 19 to to IN cord-015021-pol2qm74 3317 20 septic septic JJ cord-015021-pol2qm74 3317 21 complications complication NNS cord-015021-pol2qm74 3317 22 . . . cord-015021-pol2qm74 3318 1 The the DT cord-015021-pol2qm74 3318 2 aim aim NN cord-015021-pol2qm74 3318 3 of of IN cord-015021-pol2qm74 3318 4 this this DT cord-015021-pol2qm74 3318 5 study study NN cord-015021-pol2qm74 3318 6 was be VBD cord-015021-pol2qm74 3318 7 to to TO cord-015021-pol2qm74 3318 8 evaluate evaluate VB cord-015021-pol2qm74 3318 9 the the DT cord-015021-pol2qm74 3318 10 effect effect NN cord-015021-pol2qm74 3318 11 of of IN cord-015021-pol2qm74 3318 12 haemorrhagic haemorrhagic JJ cord-015021-pol2qm74 3318 13 shock shock NN cord-015021-pol2qm74 3318 14 ( ( -LRB- cord-015021-pol2qm74 3318 15 HS HS NNP cord-015021-pol2qm74 3318 16 ) ) -RRB- cord-015021-pol2qm74 3318 17 a a LS cord-015021-pol2qm74 3318 18 ) ) -RRB- cord-015021-pol2qm74 3318 19 on on IN cord-015021-pol2qm74 3318 20 total total JJ cord-015021-pol2qm74 3318 21 capacity capacity NN cord-015021-pol2qm74 3318 22 of of IN cord-015021-pol2qm74 3318 23 the the DT cord-015021-pol2qm74 3318 24 host host NN cord-015021-pol2qm74 3318 25 , , , cord-015021-pol2qm74 3318 26 and and CC cord-015021-pol2qm74 3318 27 b b LS cord-015021-pol2qm74 3318 28 ) ) -RRB- cord-015021-pol2qm74 3318 29 the the DT cord-015021-pol2qm74 3318 30 circulating circulate VBG cord-015021-pol2qm74 3318 31 blood blood NN cord-015021-pol2qm74 3318 32 cells cell NNS cord-015021-pol2qm74 3318 33 to to TO cord-015021-pol2qm74 3318 34 produce produce VB cord-015021-pol2qm74 3318 35 TNF TNF NNP cord-015021-pol2qm74 3318 36 immediately immediately RB cord-015021-pol2qm74 3318 37 after after IN cord-015021-pol2qm74 3318 38 bleeding bleed VBG cord-015021-pol2qm74 3318 39 . . . cord-015021-pol2qm74 3319 1 In in IN cord-015021-pol2qm74 3319 2 vivo vivo NN cord-015021-pol2qm74 3319 3 studies study NNS cord-015021-pol2qm74 3319 4 : : : cord-015021-pol2qm74 3319 5 Baboons baboon NNS cord-015021-pol2qm74 3319 6 were be VBD cord-015021-pol2qm74 3319 7 subjected subject VBN cord-015021-pol2qm74 3319 8 to to IN cord-015021-pol2qm74 3319 9 a a DT cord-015021-pol2qm74 3319 10 limited limited JJ cord-015021-pol2qm74 3319 11 oxygen oxygen NN cord-015021-pol2qm74 3319 12 deficit deficit NN cord-015021-pol2qm74 3319 13 ( ( -LRB- cord-015021-pol2qm74 3319 14 180 180 CD cord-015021-pol2qm74 3319 15 - - SYM cord-015021-pol2qm74 3319 16 200 200 CD cord-015021-pol2qm74 3319 17 ml ml NNS cord-015021-pol2qm74 3319 18 / / SYM cord-015021-pol2qm74 3319 19 kg kg NN cord-015021-pol2qm74 3319 20 ) ) -RRB- cord-015021-pol2qm74 3320 1 hypotension hypotension NN cord-015021-pol2qm74 3320 2 phase phase NN cord-015021-pol2qm74 3320 3 ( ( -LRB- cord-015021-pol2qm74 3320 4 mean mean VB cord-015021-pol2qm74 3320 5 arterial arterial JJ cord-015021-pol2qm74 3320 6 pressure pressure NN cord-015021-pol2qm74 3320 7 = = : cord-015021-pol2qm74 3320 8 MAP map NN cord-015021-pol2qm74 3320 9 of of IN cord-015021-pol2qm74 3320 10 35 35 CD cord-015021-pol2qm74 3320 11 - - SYM cord-015021-pol2qm74 3320 12 40 40 CD cord-015021-pol2qm74 3320 13 mmHg mmHg NNS cord-015021-pol2qm74 3320 14 for for IN cord-015021-pol2qm74 3320 15 2 2 CD cord-015021-pol2qm74 3320 16 - - SYM cord-015021-pol2qm74 3320 17 4 4 CD cord-015021-pol2qm74 3320 18 hours hour NNS cord-015021-pol2qm74 3320 19 followed follow VBN cord-015021-pol2qm74 3320 20 by by IN cord-015021-pol2qm74 3320 21 adequate adequate JJ cord-015021-pol2qm74 3320 22 resuscitation resuscitation NN cord-015021-pol2qm74 3320 23 ) ) -RRB- cord-015021-pol2qm74 3320 24 . . . cord-015021-pol2qm74 3321 1 Rats rat NNS cord-015021-pol2qm74 3321 2 subjected subject VBN cord-015021-pol2qm74 3321 3 to to IN cord-015021-pol2qm74 3321 4 HS HS NNP cord-015021-pol2qm74 3321 5 ( ( -LRB- cord-015021-pol2qm74 3321 6 MAP MAP NNP cord-015021-pol2qm74 3321 7 of of IN cord-015021-pol2qm74 3321 8 30 30 CD cord-015021-pol2qm74 3321 9 - - SYM cord-015021-pol2qm74 3321 10 35 35 CD cord-015021-pol2qm74 3321 11 mmHg mmHg NNS cord-015021-pol2qm74 3321 12 for for IN cord-015021-pol2qm74 3321 13 90 90 CD cord-015021-pol2qm74 3321 14 rain rain NN cord-015021-pol2qm74 3321 15 followed follow VBN cord-015021-pol2qm74 3321 16 by by IN cord-015021-pol2qm74 3321 17 reinfusion reinfusion NN cord-015021-pol2qm74 3321 18 of of IN cord-015021-pol2qm74 3321 19 shed shed JJ cord-015021-pol2qm74 3321 20 blood blood NN cord-015021-pol2qm74 3321 21 and and CC cord-015021-pol2qm74 3321 22 fluid fluid NN cord-015021-pol2qm74 3321 23 resuscitation resuscitation NN cord-015021-pol2qm74 3321 24 ) ) -RRB- cord-015021-pol2qm74 3321 25 were be VBD cord-015021-pol2qm74 3321 26 challenged challenge VBN cord-015021-pol2qm74 3321 27 with with IN cord-015021-pol2qm74 3321 28 endotoxin endotoxin NN cord-015021-pol2qm74 3321 29 ( ( -LRB- cord-015021-pol2qm74 3321 30 1 1 CD cord-015021-pol2qm74 3321 31 ~g ~g NN cord-015021-pol2qm74 3322 1 /kg /kg NFP cord-015021-pol2qm74 3322 2 i.v i.v NNP cord-015021-pol2qm74 3322 3 . . . cord-015021-pol2qm74 3322 4 ) ) -RRB- cord-015021-pol2qm74 3323 1 at at IN cord-015021-pol2qm74 3323 2 the the DT cord-015021-pol2qm74 3323 3 end end NN cord-015021-pol2qm74 3323 4 of of IN cord-015021-pol2qm74 3323 5 shock shock NN cord-015021-pol2qm74 3323 6 ( ( -LRB- cord-015021-pol2qm74 3323 7 RHS RHS NNP cord-015021-pol2qm74 3323 8 group group NN cord-015021-pol2qm74 3323 9 ) ) -RRB- cord-015021-pol2qm74 3323 10 . . . cord-015021-pol2qm74 3324 1 The the DT cord-015021-pol2qm74 3324 2 control control NN cord-015021-pol2qm74 3324 3 group group NN cord-015021-pol2qm74 3324 4 ( ( -LRB- cord-015021-pol2qm74 3324 5 RCO RCO NNP cord-015021-pol2qm74 3324 6 ) ) -RRB- cord-015021-pol2qm74 3324 7 received receive VBD cord-015021-pol2qm74 3324 8 the the DT cord-015021-pol2qm74 3324 9 same same JJ cord-015021-pol2qm74 3324 10 dose dose NN cord-015021-pol2qm74 3324 11 of of IN cord-015021-pol2qm74 3324 12 endotoxin endotoxin NN cord-015021-pol2qm74 3324 13 as as IN cord-015021-pol2qm74 3324 14 RHS RHS NNP cord-015021-pol2qm74 3324 15 group group NN cord-015021-pol2qm74 3324 16 but but CC cord-015021-pol2qm74 3324 17 without without IN cord-015021-pol2qm74 3324 18 prior prior JJ cord-015021-pol2qm74 3324 19 bleeding bleed VBG cord-015021-pol2qm74 3324 20 . . . cord-015021-pol2qm74 3325 1 In in IN cord-015021-pol2qm74 3325 2 Vitro Vitro NNP cord-015021-pol2qm74 3325 3 studies study NNS cord-015021-pol2qm74 3325 4 : : : cord-015021-pol2qm74 3325 5 Whole whole JJ cord-015021-pol2qm74 3325 6 blood blood NN cord-015021-pol2qm74 3325 7 ( ( -LRB- cord-015021-pol2qm74 3325 8 WB WB NNP cord-015021-pol2qm74 3325 9 ) ) -RRB- cord-015021-pol2qm74 3325 10 obtained obtain VBD cord-015021-pol2qm74 3325 11 from from IN cord-015021-pol2qm74 3325 12 both both DT cord-015021-pol2qm74 3325 13 baboons baboon NNS cord-015021-pol2qm74 3325 14 and and CC cord-015021-pol2qm74 3325 15 rats rat NNS cord-015021-pol2qm74 3325 16 before before IN cord-015021-pol2qm74 3325 17 and and CC cord-015021-pol2qm74 3325 18 at at IN cord-015021-pol2qm74 3325 19 the the DT cord-015021-pol2qm74 3325 20 end end NN cord-015021-pol2qm74 3325 21 of of IN cord-015021-pol2qm74 3325 22 HS HS NNP cord-015021-pol2qm74 3325 23 were be VBD cord-015021-pol2qm74 3325 24 incubated incubate VBN cord-015021-pol2qm74 3325 25 with with IN cord-015021-pol2qm74 3325 26 endotoxin endotoxin NN cord-015021-pol2qm74 3325 27 ( ( -LRB- cord-015021-pol2qm74 3325 28 100 100 CD cord-015021-pol2qm74 3325 29 ng ng NN cord-015021-pol2qm74 3325 30 / / SYM cord-015021-pol2qm74 3325 31 ml ml NN cord-015021-pol2qm74 3325 32 ) ) -RRB- cord-015021-pol2qm74 3325 33 for for IN cord-015021-pol2qm74 3325 34 2 2 CD cord-015021-pol2qm74 3325 35 hrs hrs NN cord-015021-pol2qm74 3325 36 at at IN cord-015021-pol2qm74 3325 37 37 37 CD cord-015021-pol2qm74 3325 38 ° ° NN cord-015021-pol2qm74 3325 39 C c NN cord-015021-pol2qm74 3325 40 . . . cord-015021-pol2qm74 3326 1 Results result NNS cord-015021-pol2qm74 3326 2 : : : cord-015021-pol2qm74 3327 1 At at IN cord-015021-pol2qm74 3327 2 90 90 CD cord-015021-pol2qm74 3327 3 min min NN cord-015021-pol2qm74 3327 4 post post JJ cord-015021-pol2qm74 3327 5 - - JJ cord-015021-pol2qm74 3327 6 LPS lps JJ cord-015021-pol2qm74 3327 7 challenge challenge NN cord-015021-pol2qm74 3327 8 we -PRON- PRP cord-015021-pol2qm74 3327 9 found find VBD cord-015021-pol2qm74 3327 10 significantly significantly RB cord-015021-pol2qm74 3327 11 higher high JJR cord-015021-pol2qm74 3327 12 plasma plasma NN cord-015021-pol2qm74 3327 13 TNF TNF NNP cord-015021-pol2qm74 3327 14 levels level NNS cord-015021-pol2qm74 3327 15 in in IN cord-015021-pol2qm74 3327 16 rats rat NNS cord-015021-pol2qm74 3327 17 that that WDT cord-015021-pol2qm74 3327 18 were be VBD cord-015021-pol2qm74 3327 19 subjected subject VBN cord-015021-pol2qm74 3327 20 to to IN cord-015021-pol2qm74 3327 21 HS HS NNP cord-015021-pol2qm74 3327 22 prior prior RB cord-015021-pol2qm74 3327 23 to to IN cord-015021-pol2qm74 3327 24 the the DT cord-015021-pol2qm74 3327 25 endotoxin endotoxin NN cord-015021-pol2qm74 3327 26 challenge challenge NN cord-015021-pol2qm74 3327 27 as as IN cord-015021-pol2qm74 3327 28 compared compare VBN cord-015021-pol2qm74 3327 29 to to IN cord-015021-pol2qm74 3327 30 the the DT cord-015021-pol2qm74 3327 31 control control NN cord-015021-pol2qm74 3327 32 group group NN cord-015021-pol2qm74 3327 33 ( ( -LRB- cord-015021-pol2qm74 3328 1 956 956 CD cord-015021-pol2qm74 3328 2 _ _ NN cord-015021-pol2qm74 3328 3 + + SYM cord-015021-pol2qm74 3328 4 585 585 CD cord-015021-pol2qm74 3328 5 vs vs IN cord-015021-pol2qm74 3328 6 276 276 CD cord-015021-pol2qm74 3328 7 + + SYM cord-015021-pol2qm74 3328 8 199 199 CD cord-015021-pol2qm74 3328 9 pg pg NN cord-015021-pol2qm74 3328 10 / / SYM cord-015021-pol2qm74 3328 11 ml ml NN cord-015021-pol2qm74 3328 12 ) ) -RRB- cord-015021-pol2qm74 3328 13 . . . cord-015021-pol2qm74 3329 1 After after IN cord-015021-pol2qm74 3329 2 HS HS NNP cord-015021-pol2qm74 3330 1 the the DT cord-015021-pol2qm74 3330 2 TPC TPC NNP cord-015021-pol2qm74 3330 3 was be VBD cord-015021-pol2qm74 3330 4 significantly significantly RB cord-015021-pol2qm74 3330 5 decreased decrease VBN cord-015021-pol2qm74 3330 6 in in RP cord-015021-pol2qm74 3330 7 in in IN cord-015021-pol2qm74 3330 8 vitro vitro FW cord-015021-pol2qm74 3330 9 stimulated stimulate VBD cord-015021-pol2qm74 3330 10 CBC CBC NNP cord-015021-pol2qm74 3330 11 of of IN cord-015021-pol2qm74 3330 12 both both DT cord-015021-pol2qm74 3330 13 rats rat NNS cord-015021-pol2qm74 3330 14 ( ( -LRB- cord-015021-pol2qm74 3330 15 12 12 CD cord-015021-pol2qm74 3330 16 + + SYM cord-015021-pol2qm74 3330 17 4 4 CD cord-015021-pol2qm74 3330 18 post post JJ cord-015021-pol2qm74 3330 19 - - JJ cord-015021-pol2qm74 3330 20 HS hs NN cord-015021-pol2qm74 3330 21 vs vs IN cord-015021-pol2qm74 3331 1 164 164 CD cord-015021-pol2qm74 3331 2 + + SYM cord-015021-pol2qm74 3331 3 89 89 CD cord-015021-pol2qm74 3331 4 ng ng NNP cord-015021-pol2qm74 3331 5 TNF TNF NNP cord-015021-pol2qm74 3331 6 / / SYM cord-015021-pol2qm74 3331 7 ml ml XX cord-015021-pol2qm74 3331 8 pre pre JJ cord-015021-pol2qm74 3331 9 - - JJ cord-015021-pol2qm74 3331 10 HS HS NNP cord-015021-pol2qm74 3331 11 ) ) -RRB- cord-015021-pol2qm74 3331 12 and and CC cord-015021-pol2qm74 3331 13 baboons baboon NNS cord-015021-pol2qm74 3331 14 ( ( -LRB- cord-015021-pol2qm74 3331 15 8 8 CD cord-015021-pol2qm74 3331 16 ± ± NNP cord-015021-pol2qm74 3331 17 16 16 CD cord-015021-pol2qm74 3331 18 post post JJ cord-015021-pol2qm74 3331 19 - - JJ cord-015021-pol2qm74 3331 20 HS hs NN cord-015021-pol2qm74 3331 21 vs vs IN cord-015021-pol2qm74 3331 22 233 233 CD cord-015021-pol2qm74 3331 23 ± ± CD cord-015021-pol2qm74 3331 24 188 188 CD cord-015021-pol2qm74 3332 1 pg pg NNP cord-015021-pol2qm74 3332 2 TNF TNF NNP cord-015021-pol2qm74 3332 3 / / SYM cord-015021-pol2qm74 3332 4 ml ml XX cord-015021-pol2qm74 3332 5 pre pre JJ cord-015021-pol2qm74 3332 6 - - JJ cord-015021-pol2qm74 3332 7 HS HS NNP cord-015021-pol2qm74 3332 8 ) ) -RRB- cord-015021-pol2qm74 3332 9 . . . cord-015021-pol2qm74 3333 1 In in IN cord-015021-pol2qm74 3333 2 contrast contrast NN cord-015021-pol2qm74 3333 3 , , , cord-015021-pol2qm74 3333 4 the the DT cord-015021-pol2qm74 3333 5 IL-6 IL-6 NNP cord-015021-pol2qm74 3333 6 productive productive JJ cord-015021-pol2qm74 3333 7 capacity capacity NN cord-015021-pol2qm74 3333 8 was be VBD cord-015021-pol2qm74 3333 9 increased increase VBN cord-015021-pol2qm74 3333 10 in in IN cord-015021-pol2qm74 3333 11 baboons baboon NNS cord-015021-pol2qm74 3333 12 CBC CBC NNP cord-015021-pol2qm74 3333 13 ( ( -LRB- cord-015021-pol2qm74 3333 14 not not RB cord-015021-pol2qm74 3333 15 yet yet RB cord-015021-pol2qm74 3333 16 analysed analyse VBN cord-015021-pol2qm74 3333 17 in in IN cord-015021-pol2qm74 3333 18 rats rat NNS cord-015021-pol2qm74 3333 19 ) ) -RRB- cord-015021-pol2qm74 3333 20 stimulated stimulate VBD cord-015021-pol2qm74 3333 21 at at IN cord-015021-pol2qm74 3333 22 the the DT cord-015021-pol2qm74 3333 23 end end NN cord-015021-pol2qm74 3333 24 of of IN cord-015021-pol2qm74 3333 25 HS HS NNP cord-015021-pol2qm74 3333 26 ( ( -LRB- cord-015021-pol2qm74 3333 27 224 224 CD cord-015021-pol2qm74 3333 28 ± ± CD cord-015021-pol2qm74 3333 29 106 106 CD cord-015021-pol2qm74 3333 30 pre pre NN cord-015021-pol2qm74 3333 31 - - JJ cord-015021-pol2qm74 3333 32 vs vs JJ cord-015021-pol2qm74 3333 33 1545 1545 CD cord-015021-pol2qm74 3334 1 ± ± NNP cord-015021-pol2qm74 3334 2 _ _ NN cord-015021-pol2qm74 3334 3 1254 1254 CD cord-015021-pol2qm74 3334 4 pg pg NNP cord-015021-pol2qm74 3334 5 IL-6 IL-6 NNP cord-015021-pol2qm74 3334 6 / / , cord-015021-pol2qm74 3334 7 ml ml CC cord-015021-pol2qm74 3334 8 post post JJ cord-015021-pol2qm74 3334 9 - - JJ cord-015021-pol2qm74 3334 10 HS HS NNP cord-015021-pol2qm74 3334 11 ) ) -RRB- cord-015021-pol2qm74 3334 12 . . . cord-015021-pol2qm74 3335 1 Conclusion conclusion NN cord-015021-pol2qm74 3335 2 : : : cord-015021-pol2qm74 3336 1 From from IN cord-015021-pol2qm74 3336 2 our -PRON- PRP$ cord-015021-pol2qm74 3336 3 data datum NNS cord-015021-pol2qm74 3336 4 we -PRON- PRP cord-015021-pol2qm74 3336 5 suggest suggest VBP cord-015021-pol2qm74 3336 6 that that IN cord-015021-pol2qm74 3336 7 despite despite IN cord-015021-pol2qm74 3336 8 of of IN cord-015021-pol2qm74 3336 9 down down JJ cord-015021-pol2qm74 3336 10 regulation regulation NN cord-015021-pol2qm74 3336 11 of of IN cord-015021-pol2qm74 3336 12 the the DT cord-015021-pol2qm74 3336 13 CBC CBC NNP cord-015021-pol2qm74 3336 14 to to TO cord-015021-pol2qm74 3336 15 produce produce VB cord-015021-pol2qm74 3336 16 TNF TNF NNP cord-015021-pol2qm74 3337 1 the the DT cord-015021-pol2qm74 3337 2 overall overall JJ cord-015021-pol2qm74 3337 3 TPC TPC NNP cord-015021-pol2qm74 3337 4 is be VBZ cord-015021-pol2qm74 3337 5 enhanced enhance VBN cord-015021-pol2qm74 3337 6 at at IN cord-015021-pol2qm74 3337 7 the the DT cord-015021-pol2qm74 3337 8 early early JJ cord-015021-pol2qm74 3337 9 stage stage NN cord-015021-pol2qm74 3337 10 of of IN cord-015021-pol2qm74 3337 11 I i NN cord-015021-pol2qm74 3337 12 - - HYPH cord-015021-pol2qm74 3337 13 IS be VBZ cord-015021-pol2qm74 3337 14 . . . cord-015021-pol2qm74 3338 1 With with IN cord-015021-pol2qm74 3338 2 regard regard NN cord-015021-pol2qm74 3338 3 to to IN cord-015021-pol2qm74 3338 4 the the DT cord-015021-pol2qm74 3338 5 related related JJ cord-015021-pol2qm74 3338 6 literature literature NN cord-015021-pol2qm74 3338 7 ( ( -LRB- cord-015021-pol2qm74 3338 8 Chaudry Chaudry NNP cord-015021-pol2qm74 3338 9 's 's POS cord-015021-pol2qm74 3338 10 group group NN cord-015021-pol2qm74 3338 11 ) ) -RRB- cord-015021-pol2qm74 3338 12 it -PRON- PRP cord-015021-pol2qm74 3338 13 can can MD cord-015021-pol2qm74 3338 14 be be VB cord-015021-pol2qm74 3338 15 assumed assume VBN cord-015021-pol2qm74 3338 16 that that IN cord-015021-pol2qm74 3338 17 among among IN cord-015021-pol2qm74 3338 18 the the DT cord-015021-pol2qm74 3338 19 macrophage macrophage NN cord-015021-pol2qm74 3338 20 / / SYM cord-015021-pol2qm74 3338 21 monocyte monocyte JJ cord-015021-pol2qm74 3338 22 populations population NNS cord-015021-pol2qm74 3338 23 , , , cord-015021-pol2qm74 3338 24 as as IN cord-015021-pol2qm74 3338 25 the the DT cord-015021-pol2qm74 3338 26 main main JJ cord-015021-pol2qm74 3338 27 source source NN cord-015021-pol2qm74 3338 28 only only RB cord-015021-pol2qm74 3338 29 the the DT cord-015021-pol2qm74 3338 30 Kupffer Kupffer NNP cord-015021-pol2qm74 3338 31 cells cell NNS cord-015021-pol2qm74 3338 32 ( ( -LRB- cord-015021-pol2qm74 3338 33 KC KC NNP cord-015021-pol2qm74 3338 34 ) ) -RRB- cord-015021-pol2qm74 3338 35 exhibit exhibit NN cord-015021-pol2qm74 3338 36 enhanced enhance VBN cord-015021-pol2qm74 3338 37 TNF TNF NNP cord-015021-pol2qm74 3338 38 production production NN cord-015021-pol2qm74 3338 39 capacity capacity NN cord-015021-pol2qm74 3338 40 following follow VBG cord-015021-pol2qm74 3338 41 haemorrhage haemorrhage NN cord-015021-pol2qm74 3338 42 . . . cord-015021-pol2qm74 3339 1 The the DT cord-015021-pol2qm74 3339 2 mechanisms mechanism NNS cord-015021-pol2qm74 3339 3 of of IN cord-015021-pol2qm74 3339 4 down down RB cord-015021-pol2qm74 3339 5 / / SYM cord-015021-pol2qm74 3339 6 up up JJ cord-015021-pol2qm74 3339 7 regulation regulation NN cord-015021-pol2qm74 3339 8 of of IN cord-015021-pol2qm74 3339 9 cytokine cytokine NN cord-015021-pol2qm74 3339 10 response response NN cord-015021-pol2qm74 3339 11 of of IN cord-015021-pol2qm74 3339 12 CBC CBC NNP cord-015021-pol2qm74 3339 13 and/or and/or CC cord-015021-pol2qm74 3339 14 KC KC NNP cord-015021-pol2qm74 3339 15 following follow VBG cord-015021-pol2qm74 3339 16 HS HS NNP cord-015021-pol2qm74 3339 17 remain remain VBP cord-015021-pol2qm74 3339 18 to to TO cord-015021-pol2qm74 3339 19 be be VB cord-015021-pol2qm74 3339 20 examined examine VBN cord-015021-pol2qm74 3339 21 . . . cord-015021-pol2qm74 3340 1 D. D. NNP cord-015021-pol2qm74 3341 1 Eg Eg NNP cord-015021-pol2qm74 3341 2 ~ ~ NFP cord-015021-pol2qm74 3341 3 er er UH cord-015021-pol2qm74 3341 4 , , , cord-015021-pol2qm74 3341 5 S. S. NNP cord-015021-pol2qm74 3341 6 Geuenich Geuenich NNP cord-015021-pol2qm74 3341 7 ° ° NNS cord-015021-pol2qm74 3341 8 , , , cord-015021-pol2qm74 3341 9 C. C. NNP cord-015021-pol2qm74 3341 10 Dertzlin Dertzlin NNP cord-015021-pol2qm74 3341 11 ~ ~ NFP cord-015021-pol2qm74 3341 12 er er UH cord-015021-pol2qm74 3341 13 ° ° NN cord-015021-pol2qm74 3341 14 , , , cord-015021-pol2qm74 3341 15 E. E. NNP cord-015021-pol2qm74 3341 16 Schmitt Schmitt NNP cord-015021-pol2qm74 3341 17 * * NFP cord-015021-pol2qm74 3341 18 , , , cord-015021-pol2qm74 3341 19 R. R. NNP cord-015021-pol2qm74 3341 20 Mailhammer Mailhammer NNP cord-015021-pol2qm74 3341 21 , , , cord-015021-pol2qm74 3341 22 H H NNP cord-015021-pol2qm74 3341 23 Ehrenreich Ehrenreich NNP cord-015021-pol2qm74 3341 24 # # NN cord-015021-pol2qm74 3341 25 , , , cord-015021-pol2qm74 3341 26 P. P. NNP cord-015021-pol2qm74 3341 27 Drrmer Drrmer NNP cord-015021-pol2qm74 3341 28 , , , cord-015021-pol2qm74 3341 29 and and CC cord-015021-pol2qm74 3341 30 L. L. NNP cord-015021-pol2qm74 3341 31 H01mer H01mer NNP cord-015021-pol2qm74 3341 32 GSF GSF NNP cord-015021-pol2qm74 3341 33 - - HYPH cord-015021-pol2qm74 3341 34 Instimt Instimt NNP cord-015021-pol2qm74 3341 35 fox fox NN cord-015021-pol2qm74 3341 36 Experimentelle Experimentelle NNP cord-015021-pol2qm74 3341 37 H H NNP cord-015021-pol2qm74 3341 38 ~ ~ NFP cord-015021-pol2qm74 3341 39 znatologie znatologie NN cord-015021-pol2qm74 3341 40 , , , cord-015021-pol2qm74 3341 41 ° ° NNP cord-015021-pol2qm74 3341 42 Medizinische Medizinische NNP cord-015021-pol2qm74 3341 43 Kliulk Kliulk NNP cord-015021-pol2qm74 3341 44 III III NNP cord-015021-pol2qm74 3341 45 , , , cord-015021-pol2qm74 3341 46 Klinikum Klinikum NNP cord-015021-pol2qm74 3341 47 Groghadern Groghadern NNP cord-015021-pol2qm74 3341 48 , , , cord-015021-pol2qm74 3341 49 Munich Munich NNP cord-015021-pol2qm74 3341 50 , , , cord-015021-pol2qm74 3342 1 * * NFP cord-015021-pol2qm74 3342 2 Institut Institut NNP cord-015021-pol2qm74 3342 3 for for IN cord-015021-pol2qm74 3342 4 Immunologic Immunologic NNP cord-015021-pol2qm74 3342 5 , , , cord-015021-pol2qm74 3342 6 Johannes Johannes NNP cord-015021-pol2qm74 3342 7 Gutenberg Gutenberg NNP cord-015021-pol2qm74 3342 8 Universit Universit NNP cord-015021-pol2qm74 3343 1 / / NFP cord-015021-pol2qm74 3344 1 it -PRON- PRP cord-015021-pol2qm74 3344 2 , , , cord-015021-pol2qm74 3344 3 Malnz Malnz NNP cord-015021-pol2qm74 3344 4 , , , cord-015021-pol2qm74 3344 5 and and CC cord-015021-pol2qm74 3344 6 # # $ cord-015021-pol2qm74 3344 7 Psychiatrische Psychiatrische NNP cord-015021-pol2qm74 3344 8 K/ K/ NNP cord-015021-pol2qm74 3345 1 in in IN cord-015021-pol2qm74 3345 2 & & CC cord-015021-pol2qm74 3345 3 der der NNP cord-015021-pol2qm74 3345 4 Georg Georg NNP cord-015021-pol2qm74 3345 5 - - HYPH cord-015021-pol2qm74 3345 6 Aagust Aagust NNP cord-015021-pol2qm74 3345 7 - - HYPH cord-015021-pol2qm74 3345 8 Universi Universi NNP cord-015021-pol2qm74 3346 1 ~t ~t NNP cord-015021-pol2qm74 3346 2 , , , cord-015021-pol2qm74 3346 3 Grttingen Grttingen NNP cord-015021-pol2qm74 3346 4 , , , cord-015021-pol2qm74 3346 5 Germany Germany NNP cord-015021-pol2qm74 3346 6 . . . cord-015021-pol2qm74 3347 1 It -PRON- PRP cord-015021-pol2qm74 3347 2 has have VBZ cord-015021-pol2qm74 3347 3 been be VBN cord-015021-pol2qm74 3347 4 shown show VBN cord-015021-pol2qm74 3347 5 previously previously RB cord-015021-pol2qm74 3348 1 ( ( -LRB- cord-015021-pol2qm74 3348 2 Ehranreich Ehranreich NNP cord-015021-pol2qm74 3348 3 et et NNP cord-015021-pol2qm74 3348 4 al al NNP cord-015021-pol2qm74 3348 5 . . NNP cord-015021-pol2qm74 3348 6 , , , cord-015021-pol2qm74 3348 7 1992 1992 CD cord-015021-pol2qm74 3348 8 , , , cord-015021-pol2qm74 3348 9 New New NNP cord-015021-pol2qm74 3348 10 Biol Biol NNP cord-015021-pol2qm74 3348 11 . . NNP cord-015021-pol2qm74 3348 12 4 4 CD cord-015021-pol2qm74 3348 13 : : SYM cord-015021-pol2qm74 3348 14 147 147 CD cord-015021-pol2qm74 3348 15 ) ) -RRB- cord-015021-pol2qm74 3348 16 that that IN cord-015021-pol2qm74 3348 17 mouse mouse NN cord-015021-pol2qm74 3348 18 bone bone NN cord-015021-pol2qm74 3348 19 marrow marrow NN cord-015021-pol2qm74 3348 20 - - HYPH cord-015021-pol2qm74 3348 21 derived derive VBN cord-015021-pol2qm74 3348 22 mast mast NN cord-015021-pol2qm74 3348 23 cells cell NNS cord-015021-pol2qm74 3348 24 ( ( -LRB- cord-015021-pol2qm74 3348 25 BMMC BMMC NNP cord-015021-pol2qm74 3348 26 ) ) -RRB- cord-015021-pol2qm74 3348 27 synthesize synthesize VB cord-015021-pol2qm74 3348 28 and and CC cord-015021-pol2qm74 3349 1 secrete secrete VB cord-015021-pol2qm74 3349 2 endothelin-1 endothelin-1 XX cord-015021-pol2qm74 3350 1 ( ( -LRB- cord-015021-pol2qm74 3350 2 ET et NN cord-015021-pol2qm74 3350 3 - - HYPH cord-015021-pol2qm74 3350 4 I I NNP cord-015021-pol2qm74 3350 5 ) ) -RRB- cord-015021-pol2qm74 3350 6 and and CC cord-015021-pol2qm74 3350 7 express express VB cord-015021-pol2qm74 3350 8 ETA ETA NNP cord-015021-pol2qm74 3350 9 - - HYPH cord-015021-pol2qm74 3350 10 type type NN cord-015021-pol2qm74 3350 11 endothelin endothelin NN cord-015021-pol2qm74 3350 12 receptors receptor NNS cord-015021-pol2qm74 3350 13 ( ( -LRB- cord-015021-pol2qm74 3350 14 ETA ETA NNP cord-015021-pol2qm74 3350 15 ) ) -RRB- cord-015021-pol2qm74 3350 16 . . . cord-015021-pol2qm74 3351 1 So so RB cord-015021-pol2qm74 3351 2 far far RB cord-015021-pol2qm74 3351 3 , , , cord-015021-pol2qm74 3351 4 however however RB cord-015021-pol2qm74 3351 5 , , , cord-015021-pol2qm74 3351 6 no no DT cord-015021-pol2qm74 3351 7 functions function NNS cord-015021-pol2qm74 3351 8 of of IN cord-015021-pol2qm74 3351 9 ET-1 ET-1 NNP cord-015021-pol2qm74 3351 10 / / SYM cord-015021-pol2qm74 3351 11 ET ET NNP cord-015021-pol2qm74 3351 12 A A NNP cord-015021-pol2qm74 3351 13 in in IN cord-015021-pol2qm74 3351 14 BMMC BMMC NNP cord-015021-pol2qm74 3351 15 have have VBP cord-015021-pol2qm74 3351 16 been be VBN cord-015021-pol2qm74 3351 17 described describe VBN cord-015021-pol2qm74 3351 18 . . . cord-015021-pol2qm74 3352 1 In in IN cord-015021-pol2qm74 3352 2 the the DT cord-015021-pol2qm74 3352 3 present present JJ cord-015021-pol2qm74 3352 4 study study NN cord-015021-pol2qm74 3352 5 we -PRON- PRP cord-015021-pol2qm74 3352 6 investigated investigate VBD cord-015021-pol2qm74 3352 7 the the DT cord-015021-pol2qm74 3352 8 effect effect NN cord-015021-pol2qm74 3352 9 of of IN cord-015021-pol2qm74 3353 1 exogeneously exogeneously NNP cord-015021-pol2qm74 3353 2 administered administer VBD cord-015021-pol2qm74 3353 3 ET-1 ET-1 NNP cord-015021-pol2qm74 3353 4 on on IN cord-015021-pol2qm74 3353 5 the the DT cord-015021-pol2qm74 3353 6 release release NN cord-015021-pol2qm74 3353 7 of of IN cord-015021-pol2qm74 3353 8 histamine histamine NN cord-015021-pol2qm74 3353 9 , , , cord-015021-pol2qm74 3353 10 serotonin serotonin NN cord-015021-pol2qm74 3353 11 , , , cord-015021-pol2qm74 3353 12 and and CC cord-015021-pol2qm74 3353 13 leukotriene leukotriene NN cord-015021-pol2qm74 3353 14 C C NNP cord-015021-pol2qm74 3353 15 4 4 CD cord-015021-pol2qm74 3353 16 ( ( -LRB- cord-015021-pol2qm74 3353 17 LTC4 LTC4 NNP cord-015021-pol2qm74 3353 18 ) ) -RRB- cord-015021-pol2qm74 3353 19 by by IN cord-015021-pol2qm74 3353 20 primary primary JJ cord-015021-pol2qm74 3353 21 mouse mouse NN cord-015021-pol2qm74 3353 22 BMMC BMMC NNP cord-015021-pol2qm74 3353 23 ( ( -LRB- cord-015021-pol2qm74 3353 24 in in FW cord-015021-pol2qm74 3353 25 vitro vitro FW cord-015021-pol2qm74 3353 26 age age NN cord-015021-pol2qm74 3353 27 : : : cord-015021-pol2qm74 3353 28 4 4 CD cord-015021-pol2qm74 3353 29 weeks week NNS cord-015021-pol2qm74 3353 30 ) ) -RRB- cord-015021-pol2qm74 3353 31 caltured calture VBD cord-015021-pol2qm74 3353 32 with with IN cord-015021-pol2qm74 3353 33 different different JJ cord-015021-pol2qm74 3353 34 recombinant recombinant JJ cord-015021-pol2qm74 3353 35 mttrine mttrine NN cord-015021-pol2qm74 3353 36 cytokines cytokine NNS cord-015021-pol2qm74 3353 37 ( ( -LRB- cord-015021-pol2qm74 3353 38 interleukin interleukin NN cord-015021-pol2qm74 3353 39 3 3 CD cord-015021-pol2qm74 3353 40 ( ( -LRB- cord-015021-pol2qm74 3353 41 IL-3 IL-3 NNP cord-015021-pol2qm74 3353 42 ) ) -RRB- cord-015021-pol2qm74 3353 43 and/or and/or CC cord-015021-pol2qm74 3353 44 kit kit NN cord-015021-pol2qm74 3353 45 ligand ligand NN cord-015021-pol2qm74 3353 46 ( ( -LRB- cord-015021-pol2qm74 3353 47 KL KL NNP cord-015021-pol2qm74 3353 48 ) ) -RRB- cord-015021-pol2qm74 3353 49 in in IN cord-015021-pol2qm74 3353 50 the the DT cord-015021-pol2qm74 3353 51 presence presence NN cord-015021-pol2qm74 3353 52 or or CC cord-015021-pol2qm74 3353 53 absence absence NN cord-015021-pol2qm74 3353 54 of of IN cord-015021-pol2qm74 3353 55 IL4 il4 NN cord-015021-pol2qm74 3353 56 ) ) -RRB- cord-015021-pol2qm74 3353 57 for for IN cord-015021-pol2qm74 3353 58 two two CD cord-015021-pol2qm74 3353 59 weeks week NNS cord-015021-pol2qm74 3353 60 prior prior RB cord-015021-pol2qm74 3353 61 to to IN cord-015021-pol2qm74 3353 62 activation activation NN cord-015021-pol2qm74 3353 63 . . . cord-015021-pol2qm74 3354 1 ET-1 ET-1 NNP cord-015021-pol2qm74 3354 2 ( ( -LRB- cord-015021-pol2qm74 3354 3 5x10 5x10 CD cord-015021-pol2qm74 3354 4 -8 -8 VBG cord-015021-pol2qm74 3354 5 to to IN cord-015021-pol2qm74 3354 6 lxl0 lxl0 NN cord-015021-pol2qm74 3354 7 -6 -6 NNP cord-015021-pol2qm74 3354 8 M M NNP cord-015021-pol2qm74 3355 1 ) ) -RRB- cord-015021-pol2qm74 3355 2 induCed induced WDT cord-015021-pol2qm74 3355 3 an an DT cord-015021-pol2qm74 3355 4 extremely extremely RB cord-015021-pol2qm74 3355 5 rapid rapid JJ cord-015021-pol2qm74 3355 6 ( ( -LRB- cord-015021-pol2qm74 3355 7 _ _ NN cord-015021-pol2qm74 3355 8 < < XX cord-015021-pol2qm74 3355 9 lmin lmin NNP cord-015021-pol2qm74 3355 10 ) ) -RRB- cord-015021-pol2qm74 3355 11 and and CC cord-015021-pol2qm74 3355 12 dose dose NN cord-015021-pol2qm74 3355 13 - - HYPH cord-015021-pol2qm74 3355 14 dependent dependent JJ cord-015021-pol2qm74 3355 15 release release NN cord-015021-pol2qm74 3355 16 of of IN cord-015021-pol2qm74 3355 17 histamine histamine NN cord-015021-pol2qm74 3355 18 and and CC cord-015021-pol2qm74 3355 19 serotonin serotonin NN cord-015021-pol2qm74 3355 20 ( ( -LRB- cord-015021-pol2qm74 3355 21 up up IN cord-015021-pol2qm74 3355 22 to to TO cord-015021-pol2qm74 3355 23 20 20 CD cord-015021-pol2qm74 3355 24 % % NN cord-015021-pol2qm74 3355 25 and and CC cord-015021-pol2qm74 3355 26 16 16 CD cord-015021-pol2qm74 3355 27 % % NN cord-015021-pol2qm74 3355 28 of of IN cord-015021-pol2qm74 3355 29 total total JJ cord-015021-pol2qm74 3355 30 mediator mediator NN cord-015021-pol2qm74 3355 31 content content NN cord-015021-pol2qm74 3355 32 , , , cord-015021-pol2qm74 3355 33 respectively respectively RB cord-015021-pol2qm74 3355 34 , , , cord-015021-pol2qm74 3355 35 comparable comparable JJ cord-015021-pol2qm74 3355 36 to to IN cord-015021-pol2qm74 3355 37 IgE IgE NNP cord-015021-pol2qm74 3355 38 / / SYM cord-015021-pol2qm74 3355 39 Ag Ag NNP cord-015021-pol2qm74 3355 40 - - HYPH cord-015021-pol2qm74 3355 41 indueed indueed NNP cord-015021-pol2qm74 3355 42 mediator mediator NN cord-015021-pol2qm74 3355 43 release release NN cord-015021-pol2qm74 3355 44 ) ) -RRB- cord-015021-pol2qm74 3355 45 from from IN cord-015021-pol2qm74 3355 46 BMMC BMMC NNP cord-015021-pol2qm74 3355 47 cultured culture VBN cord-015021-pol2qm74 3355 48 with with IN cord-015021-pol2qm74 3355 49 IL-3 IL-3 NNP cord-015021-pol2qm74 3355 50 and and CC cord-015021-pol2qm74 3355 51 IL-4 IL-4 NNP cord-015021-pol2qm74 3355 52 . . . cord-015021-pol2qm74 3356 1 Only only RB cord-015021-pol2qm74 3356 2 when when WRB cord-015021-pol2qm74 3356 3 cultured culture VBN cord-015021-pol2qm74 3356 4 in in IN cord-015021-pol2qm74 3356 5 the the DT cord-015021-pol2qm74 3356 6 additional additional JJ cord-015021-pol2qm74 3356 7 presence presence NN cord-015021-pol2qm74 3356 8 of of IN cord-015021-pol2qm74 3356 9 IL-4 IL-4 NNP cord-015021-pol2qm74 3356 10 rather rather RB cord-015021-pol2qm74 3356 11 than than IN cord-015021-pol2qm74 3356 12 in in IN cord-015021-pol2qm74 3356 13 medium medium NN cord-015021-pol2qm74 3356 14 containing contain VBG cord-015021-pol2qm74 3356 15 KL KL NNP cord-015021-pol2qm74 3356 16 or or CC cord-015021-pol2qm74 3356 17 KL KL NNP cord-015021-pol2qm74 3356 18 plus plus CC cord-015021-pol2qm74 3356 19 IL-3 IL-3 NNP cord-015021-pol2qm74 3357 1 alone alone RB cord-015021-pol2qm74 3357 2 , , , cord-015021-pol2qm74 3357 3 BMMC BMMC NNP cord-015021-pol2qm74 3357 4 released release VBD cord-015021-pol2qm74 3357 5 histamine histamine NN cord-015021-pol2qm74 3357 6 and and CC cord-015021-pol2qm74 3357 7 serotoaln serotoaln NN cord-015021-pol2qm74 3357 8 upon upon IN cord-015021-pol2qm74 3357 9 challenge challenge NN cord-015021-pol2qm74 3357 10 with with IN cord-015021-pol2qm74 3357 11 ET-1.Furthermore ET-1.Furthermore NNP cord-015021-pol2qm74 3357 12 , , , cord-015021-pol2qm74 3357 13 ET-1 ET-1 NNP cord-015021-pol2qm74 3357 14 stimulated stimulate VBD cord-015021-pol2qm74 3357 15 LTC LTC NNP cord-015021-pol2qm74 3357 16 4 4 CD cord-015021-pol2qm74 3357 17 biosynthesis biosynthesis NN cord-015021-pol2qm74 3357 18 up up IN cord-015021-pol2qm74 3357 19 to to IN cord-015021-pol2qm74 3357 20 4-fold 4-fold CD cord-015021-pol2qm74 3357 21 in in IN cord-015021-pol2qm74 3357 22 BMMC BMMC NNP cord-015021-pol2qm74 3357 23 cultured culture VBN cord-015021-pol2qm74 3357 24 in in IN cord-015021-pol2qm74 3357 25 the the DT cord-015021-pol2qm74 3357 26 presence presence NN cord-015021-pol2qm74 3357 27 of of IN cord-015021-pol2qm74 3357 28 IL-4 IL-4 NNP cord-015021-pol2qm74 3357 29 . . . cord-015021-pol2qm74 3358 1 In in IN cord-015021-pol2qm74 3358 2 contrast contrast NN cord-015021-pol2qm74 3358 3 , , , cord-015021-pol2qm74 3358 4 the the DT cord-015021-pol2qm74 3358 5 peptide peptide NN cord-015021-pol2qm74 3358 6 was be VBD cord-015021-pol2qm74 3358 7 without without IN cord-015021-pol2qm74 3358 8 major major JJ cord-015021-pol2qm74 3358 9 effect effect NN cord-015021-pol2qm74 3358 10 on on IN cord-015021-pol2qm74 3358 11 LTC4 LTC4 NNP cord-015021-pol2qm74 3358 12 biosynthesis biosynthesis NN cord-015021-pol2qm74 3358 13 in in IN cord-015021-pol2qm74 3358 14 BMMC BMMC NNP cord-015021-pol2qm74 3358 15 culturd culturd NNP cord-015021-pol2qm74 3358 16 without without IN cord-015021-pol2qm74 3358 17 IL-4 IL-4 NNP cord-015021-pol2qm74 3358 18 . . . cord-015021-pol2qm74 3359 1 The the DT cord-015021-pol2qm74 3359 2 release release NN cord-015021-pol2qm74 3359 3 of of IN cord-015021-pol2qm74 3359 4 histamine histamine NN cord-015021-pol2qm74 3359 5 and and CC cord-015021-pol2qm74 3359 6 sereotonin sereotonin NNP cord-015021-pol2qm74 3359 7 was be VBD cord-015021-pol2qm74 3359 8 not not RB cord-015021-pol2qm74 3359 9 altered alter VBN cord-015021-pol2qm74 3359 10 if if IN cord-015021-pol2qm74 3359 11 BMMC BMMC NNP cord-015021-pol2qm74 3359 12 were be VBD cord-015021-pol2qm74 3359 13 preincubated preincubate VBN cord-015021-pol2qm74 3359 14 for for IN cord-015021-pol2qm74 3359 15 i i PRP cord-015021-pol2qm74 3359 16 h h NNP cord-015021-pol2qm74 3359 17 with with IN cord-015021-pol2qm74 3359 18 IL-4 IL-4 NNP cord-015021-pol2qm74 3359 19 prior prior RB cord-015021-pol2qm74 3359 20 to to IN cord-015021-pol2qm74 3359 21 activation activation NN cord-015021-pol2qm74 3359 22 with with IN cord-015021-pol2qm74 3359 23 ET ET NNP cord-015021-pol2qm74 3359 24 - - : cord-015021-pol2qm74 3359 25 I I NNP cord-015021-pol2qm74 3359 26 , , , cord-015021-pol2qm74 3359 27 suggesting suggest VBG cord-015021-pol2qm74 3359 28 that that IN cord-015021-pol2qm74 3359 29 a a DT cord-015021-pol2qm74 3359 30 differentiation differentiation NN cord-015021-pol2qm74 3359 31 process process NN cord-015021-pol2qm74 3359 32 rather rather RB cord-015021-pol2qm74 3359 33 than than IN cord-015021-pol2qm74 3359 34 a a DT cord-015021-pol2qm74 3359 35 functional functional JJ cord-015021-pol2qm74 3359 36 priming priming NN cord-015021-pol2qm74 3359 37 effect effect NN cord-015021-pol2qm74 3359 38 had have VBD cord-015021-pol2qm74 3359 39 been be VBN cord-015021-pol2qm74 3359 40 initiated initiate VBN cord-015021-pol2qm74 3359 41 by by IN cord-015021-pol2qm74 3359 42 ] ] -RRB- cord-015021-pol2qm74 3360 1 L-4 L-4 NNP cord-015021-pol2qm74 3360 2 . . . cord-015021-pol2qm74 3360 3 ET-1 ET-1 NNP cord-015021-pol2qm74 3360 4 ( ( -LRB- cord-015021-pol2qm74 3360 5 10"6 10"6 NNP cord-015021-pol2qm74 3360 6 M M NNP cord-015021-pol2qm74 3360 7 ) ) -RRB- cord-015021-pol2qm74 3361 1 -induced -induced JJ cord-015021-pol2qm74 3361 2 histamine histamine NN cord-015021-pol2qm74 3361 3 and and CC cord-015021-pol2qm74 3361 4 serotouln serotouln NNP cord-015021-pol2qm74 3361 5 release release NN cord-015021-pol2qm74 3361 6 from from IN cord-015021-pol2qm74 3361 7 BMMC BMMC NNP cord-015021-pol2qm74 3361 8 was be VBD cord-015021-pol2qm74 3361 9 inhibited inhibit VBN cord-015021-pol2qm74 3361 10 by by IN cord-015021-pol2qm74 3361 11 an an DT cord-015021-pol2qm74 3361 12 ETA ETA NNP cord-015021-pol2qm74 3361 13 - - HYPH cord-015021-pol2qm74 3361 14 specific specific JJ cord-015021-pol2qm74 3361 15 antagonist antagonist NN cord-015021-pol2qm74 3361 16 ( ( -LRB- cord-015021-pol2qm74 3361 17 cyclic cyclic JJ cord-015021-pol2qm74 3361 18 ID ID NNP cord-015021-pol2qm74 3361 19 - - HYPH cord-015021-pol2qm74 3361 20 Asp Asp NNP cord-015021-pol2qm74 3361 21 - - HYPH cord-015021-pol2qm74 3361 22 Pro pro JJ cord-015021-pol2qm74 3361 23 - - JJ cord-015021-pol2qm74 3361 24 D d JJ cord-015021-pol2qm74 3361 25 - - HYPH cord-015021-pol2qm74 3361 26 Val Val NNP cord-015021-pol2qm74 3361 27 - - HYPH cord-015021-pol2qm74 3361 28 Leu Leu NNP cord-015021-pol2qm74 3361 29 - - HYPH cord-015021-pol2qm74 3361 30 D D NNP cord-015021-pol2qm74 3361 31 - - HYPH cord-015021-pol2qm74 3361 32 Tel Tel NNP cord-015021-pol2qm74 3361 33 ) ) -RRB- cord-015021-pol2qm74 3361 34 in in IN cord-015021-pol2qm74 3361 35 a a DT cord-015021-pol2qm74 3361 36 dose dose NN cord-015021-pol2qm74 3361 37 - - HYPH cord-015021-pol2qm74 3361 38 dependent dependent JJ cord-015021-pol2qm74 3361 39 manner manner NN cord-015021-pol2qm74 3361 40 , , , cord-015021-pol2qm74 3361 41 with with IN cord-015021-pol2qm74 3361 42 a a DT cord-015021-pol2qm74 3361 43 complete complete JJ cord-015021-pol2qm74 3361 44 inhibition inhibition NN cord-015021-pol2qm74 3361 45 observed observe VBD cord-015021-pol2qm74 3361 46 at at IN cord-015021-pol2qm74 3361 47 an an DT cord-015021-pol2qm74 3361 48 antagonist antagonist NN cord-015021-pol2qm74 3361 49 concentration concentration NN cord-015021-pol2qm74 3361 50 of of IN cord-015021-pol2qm74 3361 51 10 10 CD cord-015021-pol2qm74 3361 52 -8 -8 NNP cord-015021-pol2qm74 3361 53 M. M. NNP cord-015021-pol2qm74 3361 54 Crude Crude NNP cord-015021-pol2qm74 3361 55 peritoneal peritoneal JJ cord-015021-pol2qm74 3361 56 cells cell NNS cord-015021-pol2qm74 3361 57 ( ( -LRB- cord-015021-pol2qm74 3361 58 containing contain VBG cord-015021-pol2qm74 3361 59 2 2 CD cord-015021-pol2qm74 3361 60 - - SYM cord-015021-pol2qm74 3361 61 3 3 CD cord-015021-pol2qm74 3361 62 % % NN cord-015021-pol2qm74 3361 63 serosal serosal NN cord-015021-pol2qm74 3361 64 mast mast NN cord-015021-pol2qm74 3361 65 cells cell NNS cord-015021-pol2qm74 3361 66 ) ) -RRB- cord-015021-pol2qm74 3361 67 obtained obtain VBD cord-015021-pol2qm74 3361 68 from from IN cord-015021-pol2qm74 3361 69 normal normal JJ cord-015021-pol2qm74 3361 70 BALB BALB NNP cord-015021-pol2qm74 3361 71 / / SYM cord-015021-pol2qm74 3361 72 c c NNP cord-015021-pol2qm74 3361 73 - - HYPH cord-015021-pol2qm74 3361 74 mice mouse NNS cord-015021-pol2qm74 3361 75 released release VBD cord-015021-pol2qm74 3361 76 87 87 CD cord-015021-pol2qm74 3361 77 % % NN cord-015021-pol2qm74 3361 78 histamine histamine NN cord-015021-pol2qm74 3361 79 upon upon IN cord-015021-pol2qm74 3361 80 challenge challenge NN cord-015021-pol2qm74 3361 81 with with IN cord-015021-pol2qm74 3361 82 ET-1 ET-1 NNP cord-015021-pol2qm74 3361 83 ( ( -LRB- cord-015021-pol2qm74 3361 84 10 10 CD cord-015021-pol2qm74 3361 85 -6 -6 NNP cord-015021-pol2qm74 3361 86 M M NNP cord-015021-pol2qm74 3361 87 ; ; : cord-015021-pol2qm74 3361 88 20 20 CD cord-015021-pol2qm74 3361 89 rain rain NN cord-015021-pol2qm74 3361 90 ) ) -RRB- cord-015021-pol2qm74 3361 91 . . . cord-015021-pol2qm74 3362 1 Taken take VBN cord-015021-pol2qm74 3362 2 together together RB cord-015021-pol2qm74 3362 3 , , , cord-015021-pol2qm74 3362 4 these these DT cord-015021-pol2qm74 3362 5 resu resu NN cord-015021-pol2qm74 3362 6 / / SYM cord-015021-pol2qm74 3362 7 ts t NNS cord-015021-pol2qm74 3362 8 demonstrate demonstrate VBP cord-015021-pol2qm74 3362 9 that that IN cord-015021-pol2qm74 3362 10 ET-1 ET-1 NNP cord-015021-pol2qm74 3362 11 can can MD cord-015021-pol2qm74 3362 12 directly directly RB cord-015021-pol2qm74 3362 13 function function VB cord-015021-pol2qm74 3362 14 as as IN cord-015021-pol2qm74 3362 15 a a DT cord-015021-pol2qm74 3362 16 histamine histamine NN cord-015021-pol2qm74 3362 17 and and CC cord-015021-pol2qm74 3362 18 serotohin serotohin NNP cord-015021-pol2qm74 3362 19 secretagogue secretagogue NNP cord-015021-pol2qm74 3362 20 and and CC cord-015021-pol2qm74 3362 21 as as IN cord-015021-pol2qm74 3362 22 a a DT cord-015021-pol2qm74 3362 23 stimulator stimulator NN cord-015021-pol2qm74 3362 24 of of IN cord-015021-pol2qm74 3362 25 LTC LTC NNP cord-015021-pol2qm74 3362 26 4 4 CD cord-015021-pol2qm74 3362 27 production production NN cord-015021-pol2qm74 3362 28 in in IN cord-015021-pol2qm74 3362 29 mast mast NN cord-015021-pol2qm74 3362 30 cells cell NNS cord-015021-pol2qm74 3362 31 . . . cord-015021-pol2qm74 3363 1 IL-4 IL-4 NNP cord-015021-pol2qm74 3363 2 appears appear VBZ cord-015021-pol2qm74 3363 3 to to TO cord-015021-pol2qm74 3363 4 be be VB cord-015021-pol2qm74 3363 5 involved involve VBN cord-015021-pol2qm74 3363 6 in in IN cord-015021-pol2qm74 3363 7 the the DT cord-015021-pol2qm74 3363 8 differentiation differentiation NN cord-015021-pol2qm74 3363 9 of of IN cord-015021-pol2qm74 3363 10 immature immature JJ cord-015021-pol2qm74 3363 11 mast mast JJ cord-015021-pol2qm74 3363 12 cell cell NN cord-015021-pol2qm74 3363 13 prec prec NN cord-015021-pol2qm74 3363 14 ~ ~ NFP cord-015021-pol2qm74 3363 15 trsors trsor NNS cord-015021-pol2qm74 3363 16 towards towards IN cord-015021-pol2qm74 3363 17 an an DT cord-015021-pol2qm74 3363 18 ET ET NNP cord-015021-pol2qm74 3363 19 - - HYPH cord-015021-pol2qm74 3363 20 l l NN cord-015021-pol2qm74 3363 21 - - HYPH cord-015021-pol2qm74 3363 22 reactive reactive JJ cord-015021-pol2qm74 3363 23 functional functional JJ cord-015021-pol2qm74 3363 24 phenotype phenotype NN cord-015021-pol2qm74 3363 25 . . . cord-015021-pol2qm74 3364 1 When when WRB cord-015021-pol2qm74 3364 2 inflammatory inflammatory JJ cord-015021-pol2qm74 3364 3 reactions reaction NNS cord-015021-pol2qm74 3364 4 are be VBP cord-015021-pol2qm74 3364 5 advanced advanced JJ cord-015021-pol2qm74 3364 6 , , , cord-015021-pol2qm74 3364 7 type type NN cord-015021-pol2qm74 3364 8 II II NNP cord-015021-pol2qm74 3364 9 phospholipase phospholipase NN cord-015021-pol2qm74 3364 10 A2 A2 NNP cord-015021-pol2qm74 3364 11 ( ( -LRB- cord-015021-pol2qm74 3364 12 type type NN cord-015021-pol2qm74 3364 13 II II NNP cord-015021-pol2qm74 3364 14 PLA2 PLA2 NNP cord-015021-pol2qm74 3364 15 ) ) -RRB- cord-015021-pol2qm74 3364 16 is be VBZ cord-015021-pol2qm74 3364 17 produced produce VBN cord-015021-pol2qm74 3364 18 in in IN cord-015021-pol2qm74 3364 19 high high JJ cord-015021-pol2qm74 3364 20 levels level NNS cord-015021-pol2qm74 3364 21 by by IN cord-015021-pol2qm74 3364 22 various various JJ cord-015021-pol2qm74 3364 23 cells cell NNS cord-015021-pol2qm74 3364 24 at at IN cord-015021-pol2qm74 3364 25 the the DT cord-015021-pol2qm74 3364 26 site site NN cord-015021-pol2qm74 3364 27 of of IN cord-015021-pol2qm74 3364 28 inflammation inflammation NN cord-015021-pol2qm74 3364 29 . . . cord-015021-pol2qm74 3365 1 Cytokines cytokine NNS cord-015021-pol2qm74 3365 2 such such JJ cord-015021-pol2qm74 3365 3 as as IN cord-015021-pol2qm74 3365 4 TNF TNF NNP cord-015021-pol2qm74 3365 5 - - : cord-015021-pol2qm74 3365 6 a a NN cord-015021-pol2qm74 3365 7 and and CC cord-015021-pol2qm74 3366 1 IL IL NNP cord-015021-pol2qm74 3366 2 - - : cord-015021-pol2qm74 3366 3 I -PRON- PRP cord-015021-pol2qm74 3366 4 activate activate VBP cord-015021-pol2qm74 3366 5 type type NN cord-015021-pol2qm74 3366 6 II II NNP cord-015021-pol2qm74 3366 7 PLA2 PLA2 NNP cord-015021-pol2qm74 3366 8 and and CC cord-015021-pol2qm74 3366 9 promote promote VB cord-015021-pol2qm74 3366 10 the the DT cord-015021-pol2qm74 3366 11 production production NN cord-015021-pol2qm74 3366 12 of of IN cord-015021-pol2qm74 3366 13 eicosanoid eicosanoid NNP cord-015021-pol2qm74 3366 14 , , , cord-015021-pol2qm74 3366 15 which which WDT cord-015021-pol2qm74 3366 16 is be VBZ cord-015021-pol2qm74 3366 17 one one CD cord-015021-pol2qm74 3366 18 of of IN cord-015021-pol2qm74 3366 19 the the DT cord-015021-pol2qm74 3366 20 mechanisms mechanism NNS cord-015021-pol2qm74 3366 21 by by IN cord-015021-pol2qm74 3366 22 which which WDT cord-015021-pol2qm74 3366 23 they -PRON- PRP cord-015021-pol2qm74 3366 24 enhance enhance VBP cord-015021-pol2qm74 3366 25 the the DT cord-015021-pol2qm74 3366 26 inflammatory inflammatory JJ cord-015021-pol2qm74 3366 27 reaction reaction NN cord-015021-pol2qm74 3366 28 . . . cord-015021-pol2qm74 3367 1 In in IN cord-015021-pol2qm74 3367 2 the the DT cord-015021-pol2qm74 3367 3 present present JJ cord-015021-pol2qm74 3367 4 study study NN cord-015021-pol2qm74 3367 5 , , , cord-015021-pol2qm74 3367 6 the the DT cord-015021-pol2qm74 3367 7 blood blood NN cord-015021-pol2qm74 3367 8 levels level NNS cord-015021-pol2qm74 3367 9 of of IN cord-015021-pol2qm74 3367 10 type type NN cord-015021-pol2qm74 3367 11 II II NNP cord-015021-pol2qm74 3367 12 PEA2 PEA2 NNP cord-015021-pol2qm74 3367 13 , , , cord-015021-pol2qm74 3367 14 endotoxin endotoxin NN cord-015021-pol2qm74 3367 15 , , . cord-015021-pol2qm74 3368 1 TNF TNF NNP cord-015021-pol2qm74 3368 2 - - HYPH cord-015021-pol2qm74 3368 3 c~ c~ NNP cord-015021-pol2qm74 3368 4 , , , cord-015021-pol2qm74 3369 1 IL-6 IL-6 NNP cord-015021-pol2qm74 3369 2 and and CC cord-015021-pol2qm74 3369 3 IL-8 IL-8 NNP cord-015021-pol2qm74 3369 4 were be VBD cord-015021-pol2qm74 3369 5 determined determine VBN cord-015021-pol2qm74 3369 6 in in IN cord-015021-pol2qm74 3369 7 patients patient NNS cord-015021-pol2qm74 3369 8 with with IN cord-015021-pol2qm74 3369 9 sepsis sepsis NN cord-015021-pol2qm74 3369 10 to to TO cord-015021-pol2qm74 3369 11 examine examine VB cord-015021-pol2qm74 3369 12 the the DT cord-015021-pol2qm74 3369 13 relationship relationship NN cord-015021-pol2qm74 3369 14 between between IN cord-015021-pol2qm74 3369 15 these these DT cord-015021-pol2qm74 3369 16 levels level NNS cord-015021-pol2qm74 3369 17 and and CC cord-015021-pol2qm74 3369 18 the the DT cord-015021-pol2qm74 3369 19 patients patient NNS cord-015021-pol2qm74 3369 20 ' ' POS cord-015021-pol2qm74 3369 21 pathological pathological JJ cord-015021-pol2qm74 3369 22 conditions condition NNS cord-015021-pol2qm74 3369 23 . . . cord-015021-pol2qm74 3370 1 The the DT cord-015021-pol2qm74 3370 2 levels level NNS cord-015021-pol2qm74 3370 3 of of IN cord-015021-pol2qm74 3370 4 type type NN cord-015021-pol2qm74 3370 5 II II NNP cord-015021-pol2qm74 3370 6 PLA2 PLA2 NNP cord-015021-pol2qm74 3370 7 and and CC cord-015021-pol2qm74 3370 8 TNF TNF NNP cord-015021-pol2qm74 3370 9 - - , cord-015021-pol2qm74 3370 10 a a NN cord-015021-pol2qm74 3370 11 in in IN cord-015021-pol2qm74 3370 12 these these DT cord-015021-pol2qm74 3370 13 patients patient NNS cord-015021-pol2qm74 3370 14 were be VBD cord-015021-pol2qm74 3370 15 218.3 218.3 CD cord-015021-pol2qm74 3370 16 ± ± CD cord-015021-pol2qm74 3370 17 179.9 179.9 CD cord-015021-pol2qm74 3370 18 ng ng NNP cord-015021-pol2qm74 3370 19 / / SYM cord-015021-pol2qm74 3370 20 ml ml NN cord-015021-pol2qm74 3370 21 and and CC cord-015021-pol2qm74 3370 22 98.5 98.5 CD cord-015021-pol2qm74 3370 23 ± ± NNP cord-015021-pol2qm74 3370 24 92.1 92.1 CD cord-015021-pol2qm74 3370 25 pg pg NNP cord-015021-pol2qm74 3370 26 / / SYM cord-015021-pol2qm74 3370 27 ml ml NNS cord-015021-pol2qm74 3370 28 , , , cord-015021-pol2qm74 3370 29 respectively respectively RB cord-015021-pol2qm74 3370 30 , , , cord-015021-pol2qm74 3370 31 the the DT cord-015021-pol2qm74 3370 32 two two CD cord-015021-pol2qm74 3370 33 parameters parameter NNS cord-015021-pol2qm74 3370 34 being be VBG cord-015021-pol2qm74 3370 35 significantly significantly RB cord-015021-pol2qm74 3370 36 correlated correlate VBN cord-015021-pol2qm74 3370 37 ( ( -LRB- cord-015021-pol2qm74 3370 38 r r NN cord-015021-pol2qm74 3370 39 = = SYM cord-015021-pol2qm74 3370 40 0.6460 0.6460 CD cord-015021-pol2qm74 3370 41 , , , cord-015021-pol2qm74 3370 42 p p NN cord-015021-pol2qm74 3370 43 = = SYM cord-015021-pol2qm74 3370 44 0.0001 0.0001 CD cord-015021-pol2qm74 3370 45 ) ) -RRB- cord-015021-pol2qm74 3370 46 . . . cord-015021-pol2qm74 3371 1 There there EX cord-015021-pol2qm74 3371 2 were be VBD cord-015021-pol2qm74 3371 3 also also RB cord-015021-pol2qm74 3371 4 a a DT cord-015021-pol2qm74 3371 5 significant significant JJ cord-015021-pol2qm74 3371 6 correlation correlation NN cord-015021-pol2qm74 3371 7 between between IN cord-015021-pol2qm74 3371 8 the the DT cord-015021-pol2qm74 3371 9 level level NN cord-015021-pol2qm74 3371 10 of of IN cord-015021-pol2qm74 3371 11 type type NN cord-015021-pol2qm74 3371 12 II II NNP cord-015021-pol2qm74 3371 13 PLA2 PLA2 NNP cord-015021-pol2qm74 3371 14 an an DT cord-015021-pol2qm74 3371 15 IL-6 IL-6 NNP cord-015021-pol2qm74 3371 16 ( ( -LRB- cord-015021-pol2qm74 3371 17 r r NN cord-015021-pol2qm74 3371 18 = = SYM cord-015021-pol2qm74 3371 19 0.4262 0.4262 CD cord-015021-pol2qm74 3371 20 , , , cord-015021-pol2qm74 3371 21 p p NN cord-015021-pol2qm74 3371 22 = = SYM cord-015021-pol2qm74 3371 23 0.0188 0.0188 CD cord-015021-pol2qm74 3371 24 ) ) -RRB- cord-015021-pol2qm74 3371 25 . . . cord-015021-pol2qm74 3372 1 There there EX cord-015021-pol2qm74 3372 2 was be VBD cord-015021-pol2qm74 3372 3 no no DT cord-015021-pol2qm74 3372 4 significant significant JJ cord-015021-pol2qm74 3372 5 correlation correlation NN cord-015021-pol2qm74 3372 6 between between IN cord-015021-pol2qm74 3372 7 the the DT cord-015021-pol2qm74 3372 8 level level NN cord-015021-pol2qm74 3372 9 of of IN cord-015021-pol2qm74 3372 10 type type NN cord-015021-pol2qm74 3372 11 II II NNP cord-015021-pol2qm74 3372 12 PLA2 PLA2 NNP cord-015021-pol2qm74 3372 13 and and CC cord-015021-pol2qm74 3372 14 IL-8 IL-8 NNP cord-015021-pol2qm74 3372 15 . . . cord-015021-pol2qm74 3373 1 These these DT cord-015021-pol2qm74 3373 2 in in IN cord-015021-pol2qm74 3373 3 vivo vivo NN cord-015021-pol2qm74 3373 4 findings finding NNS cord-015021-pol2qm74 3373 5 suggest suggest VBP cord-015021-pol2qm74 3373 6 that that IN cord-015021-pol2qm74 3373 7 TNF TNF NNP cord-015021-pol2qm74 3373 8 - - : cord-015021-pol2qm74 3373 9 a a DT cord-015021-pol2qm74 3373 10 may may MD cord-015021-pol2qm74 3373 11 be be VB cord-015021-pol2qm74 3373 12 involved involve VBN cord-015021-pol2qm74 3373 13 in in IN cord-015021-pol2qm74 3373 14 the the DT cord-015021-pol2qm74 3373 15 production production NN cord-015021-pol2qm74 3373 16 of of IN cord-015021-pol2qm74 3373 17 type type NN cord-015021-pol2qm74 3373 18 II II NNP cord-015021-pol2qm74 3373 19 PLA2 PLA2 NNP cord-015021-pol2qm74 3373 20 . . . cord-015021-pol2qm74 3373 21 _SP cord-015021-pol2qm74 3374 1 A. A. NNP cord-015021-pol2qm74 3374 2 Filzmaver Filzmaver NNP cord-015021-pol2qm74 3374 3 , , , cord-015021-pol2qm74 3374 4 G. G. NNP cord-015021-pol2qm74 3374 5 Reisbach Reisbach NNP cord-015021-pol2qm74 3374 6 , , , cord-015021-pol2qm74 3374 7 E. E. NNP cord-015021-pol2qm74 3374 8 Schmitt Schmitt NNP cord-015021-pol2qm74 3374 9 ° ° NN cord-015021-pol2qm74 3374 10 , , , cord-015021-pol2qm74 3374 11 R. R. NNP cord-015021-pol2qm74 3374 12 Mailhammer Mailhammer NNP cord-015021-pol2qm74 3374 13 , , , cord-015021-pol2qm74 3374 14 and and CC cord-015021-pol2qm74 3374 15 L. L. NNP cord-015021-pol2qm74 3374 16 Hiittner Hiittner NNP cord-015021-pol2qm74 3374 17 . . . cord-015021-pol2qm74 3375 1 GSF GSF NNP cord-015021-pol2qm74 3375 2 - - HYPH cord-015021-pol2qm74 3375 3 Iustitut Iustitut NNP cord-015021-pol2qm74 3375 4 ff ff NN cord-015021-pol2qm74 3376 1 ~r ~r XX cord-015021-pol2qm74 3376 2 Experimentelle Experimentelle NNP cord-015021-pol2qm74 3376 3 H H NNP cord-015021-pol2qm74 3376 4 ~ ~ NFP cord-015021-pol2qm74 3376 5 imatologie imatologie NN cord-015021-pol2qm74 3376 6 , , , cord-015021-pol2qm74 3376 7 Munich Munich NNP cord-015021-pol2qm74 3376 8 , , , cord-015021-pol2qm74 3376 9 and and CC cord-015021-pol2qm74 3376 10 ° ° NNP cord-015021-pol2qm74 3376 11 Iustitut Iustitut NNP cord-015021-pol2qm74 3376 12 fttr fttr NN cord-015021-pol2qm74 3376 13 Immunelone Immunelone NNP cord-015021-pol2qm74 3376 14 , , , cord-015021-pol2qm74 3376 15 Johannes Johannes NNP cord-015021-pol2qm74 3376 16 Gutenberg Gutenberg NNP cord-015021-pol2qm74 3376 17 Universit Universit NNP cord-015021-pol2qm74 3377 1 ~t ~t NNP cord-015021-pol2qm74 3377 2 , , , cord-015021-pol2qm74 3377 3 Mainz Mainz NNP cord-015021-pol2qm74 3377 4 , , , cord-015021-pol2qm74 3377 5 Germany Germany NNP cord-015021-pol2qm74 3378 1 The the DT cord-015021-pol2qm74 3378 2 product product NN cord-015021-pol2qm74 3378 3 of of IN cord-015021-pol2qm74 3378 4 c c NN cord-015021-pol2qm74 3378 5 - - HYPH cord-015021-pol2qm74 3378 6 kit kit NN cord-015021-pol2qm74 3378 7 , , , cord-015021-pol2qm74 3378 8 a a DT cord-015021-pol2qm74 3378 9 transmembrane transmembrane NNP cord-015021-pol2qm74 3378 10 tyrosin tyrosin NNP cord-015021-pol2qm74 3378 11 ldnase ldnase NNP cord-015021-pol2qm74 3378 12 receptor receptor NN cord-015021-pol2qm74 3378 13 , , , cord-015021-pol2qm74 3378 14 and and CC cord-015021-pol2qm74 3378 15 a a DT cord-015021-pol2qm74 3378 16 corresponding correspond VBG cord-015021-pol2qm74 3378 17 kit kit NN cord-015021-pol2qm74 3378 18 ligand ligand NN cord-015021-pol2qm74 3378 19 ( ( -LRB- cord-015021-pol2qm74 3378 20 KL KL NNP cord-015021-pol2qm74 3378 21 ) ) -RRB- cord-015021-pol2qm74 3378 22 are be VBP cord-015021-pol2qm74 3378 23 critically critically RB cord-015021-pol2qm74 3378 24 involved involve VBN cord-015021-pol2qm74 3378 25 in in IN cord-015021-pol2qm74 3378 26 the the DT cord-015021-pol2qm74 3378 27 control control NN cord-015021-pol2qm74 3378 28 of of IN cord-015021-pol2qm74 3378 29 different different JJ cord-015021-pol2qm74 3378 30 hemopoietic hemopoietic JJ cord-015021-pol2qm74 3378 31 cell cell NN cord-015021-pol2qm74 3378 32 lineages lineage NNS cord-015021-pol2qm74 3378 33 including include VBG cord-015021-pol2qm74 3378 34 the the DT cord-015021-pol2qm74 3378 35 proliferation proliferation NN cord-015021-pol2qm74 3378 36 , , , cord-015021-pol2qm74 3378 37 maturation maturation NN cord-015021-pol2qm74 3378 38 , , , cord-015021-pol2qm74 3378 39 migration migration NN cord-015021-pol2qm74 3378 40 , , , cord-015021-pol2qm74 3378 41 and and CC cord-015021-pol2qm74 3378 42 function function NN cord-015021-pol2qm74 3378 43 of of IN cord-015021-pol2qm74 3378 44 mast mast NN cord-015021-pol2qm74 3378 45 cells cell NNS cord-015021-pol2qm74 3378 46 . . . cord-015021-pol2qm74 3379 1 It -PRON- PRP cord-015021-pol2qm74 3379 2 has have VBZ cord-015021-pol2qm74 3379 3 been be VBN cord-015021-pol2qm74 3379 4 reported report VBN cord-015021-pol2qm74 3379 5 previously previously RB cord-015021-pol2qm74 3379 6 that that IN cord-015021-pol2qm74 3379 7 interleukin interleukin NN cord-015021-pol2qm74 3379 8 ( ( -LRB- cord-015021-pol2qm74 3379 9 IL)-4 IL)-4 NNP cord-015021-pol2qm74 3379 10 down down RB cord-015021-pol2qm74 3379 11 - - HYPH cord-015021-pol2qm74 3379 12 regulates regulates NN cord-015021-pol2qm74 3379 13 kit kit NN cord-015021-pol2qm74 3379 14 receptors receptor NNS cord-015021-pol2qm74 3379 15 in in IN cord-015021-pol2qm74 3379 16 human human JJ cord-015021-pol2qm74 3379 17 primary primary JJ cord-015021-pol2qm74 3379 18 myeloid myeloid JJ cord-015021-pol2qm74 3379 19 leukemic leukemic JJ cord-015021-pol2qm74 3379 20 cells cell NNS cord-015021-pol2qm74 3379 21 and and CC cord-015021-pol2qm74 3379 22 in in IN cord-015021-pol2qm74 3379 23 a a DT cord-015021-pol2qm74 3379 24 human human JJ cord-015021-pol2qm74 3379 25 mast mast NN cord-015021-pol2qm74 3379 26 celt celt NN cord-015021-pol2qm74 3379 27 line line NN cord-015021-pol2qm74 3379 28 ( ( -LRB- cord-015021-pol2qm74 3379 29 Sinaber Sinaber NNP cord-015021-pol2qm74 3379 30 et et FW cord-015021-pol2qm74 3379 31 al al NNP cord-015021-pol2qm74 3379 32 . . . cord-015021-pol2qm74 3380 1 1991 1991 CD cord-015021-pol2qm74 3380 2 , , , cord-015021-pol2qm74 3380 3 J. J. NNP cord-015021-pol2qm74 3380 4 Immunol Immunol NNP cord-015021-pol2qm74 3380 5 . . . cord-015021-pol2qm74 3380 6 147 147 CD cord-015021-pol2qm74 3380 7 : : : cord-015021-pol2qm74 3380 8 4224 4224 CD cord-015021-pol2qm74 3380 9 ) ) -RRB- cord-015021-pol2qm74 3380 10 . . . cord-015021-pol2qm74 3381 1 Transforming transform VBG cord-015021-pol2qm74 3381 2 growth growth NN cord-015021-pol2qm74 3381 3 factor factor NN cord-015021-pol2qm74 3381 4 ( ( -LRB- cord-015021-pol2qm74 3381 5 TGF TGF NNP cord-015021-pol2qm74 3381 6 ) ) -RRB- cord-015021-pol2qm74 3381 7 gl gl NNP cord-015021-pol2qm74 3381 8 , , , cord-015021-pol2qm74 3381 9 was be VBD cord-015021-pol2qm74 3381 10 also also RB cord-015021-pol2qm74 3381 11 found find VBN cord-015021-pol2qm74 3381 12 to to IN cord-015021-pol2qm74 3381 13 down down RB cord-015021-pol2qm74 3381 14 - - HYPH cord-015021-pol2qm74 3381 15 modulate modulate VB cord-015021-pol2qm74 3381 16 c c NN cord-015021-pol2qm74 3381 17 - - HYPH cord-015021-pol2qm74 3381 18 kit kit NN cord-015021-pol2qm74 3381 19 mRNA mRNA NNP cord-015021-pol2qm74 3381 20 and and CC cord-015021-pol2qm74 3381 21 kit kit NN cord-015021-pol2qm74 3381 22 receptor receptor NN cord-015021-pol2qm74 3381 23 proteins protein NNS cord-015021-pol2qm74 3381 24 in in IN cord-015021-pol2qm74 3381 25 human human JJ cord-015021-pol2qm74 3381 26 AML AML NNP cord-015021-pol2qm74 3381 27 blasts blast NNS cord-015021-pol2qm74 3381 28 , , , cord-015021-pol2qm74 3381 29 a a DT cord-015021-pol2qm74 3381 30 mechanism mechanism NN cord-015021-pol2qm74 3381 31 probabely probabely RB cord-015021-pol2qm74 3381 32 contributing contribute VBG cord-015021-pol2qm74 3381 33 to to IN cord-015021-pol2qm74 3381 34 the the DT cord-015021-pol2qm74 3381 35 anti anti JJ cord-015021-pol2qm74 3381 36 - - JJ cord-015021-pol2qm74 3381 37 proliferative proliferative JJ cord-015021-pol2qm74 3381 38 effect effect NN cord-015021-pol2qm74 3381 39 of of IN cord-015021-pol2qm74 3381 40 TGFIH TGFIH NNP cord-015021-pol2qm74 3381 41 on on IN cord-015021-pol2qm74 3381 42 KL KL NNP cord-015021-pol2qm74 3381 43 - - HYPH cord-015021-pol2qm74 3381 44 stimulated stimulate VBN cord-015021-pol2qm74 3381 45 AML AML NNP cord-015021-pol2qm74 3381 46 ceils ceil NNS cord-015021-pol2qm74 3381 47 in in IN cord-015021-pol2qm74 3381 48 vitro vitro FW cord-015021-pol2qm74 3381 49 ( ( -LRB- cord-015021-pol2qm74 3381 50 de de FW cord-015021-pol2qm74 3381 51 Vos vos FW cord-015021-pol2qm74 3381 52 et et FW cord-015021-pol2qm74 3381 53 at at IN cord-015021-pol2qm74 3381 54 . . . cord-015021-pol2qm74 3381 55 1993 1993 CD cord-015021-pol2qm74 3381 56 , , , cord-015021-pol2qm74 3381 57 Cancer Cancer NNP cord-015021-pol2qm74 3381 58 Res Res NNP cord-015021-pol2qm74 3381 59 . . NNP cord-015021-pol2qm74 3381 60 53 53 CD cord-015021-pol2qm74 3381 61 : : : cord-015021-pol2qm74 3381 62 3638 3638 CD cord-015021-pol2qm74 3381 63 ) ) -RRB- cord-015021-pol2qm74 3381 64 . . . cord-015021-pol2qm74 3382 1 In in IN cord-015021-pol2qm74 3382 2 porcine porcine JJ cord-015021-pol2qm74 3382 3 endothelial endothelial JJ cord-015021-pol2qm74 3382 4 cells cell NNS cord-015021-pol2qm74 3382 5 transfected transfecte VBN cord-015021-pol2qm74 3382 6 with with IN cord-015021-pol2qm74 3382 7 a a DT cord-015021-pol2qm74 3382 8 retroviral retroviral NN cord-015021-pol2qm74 3382 9 construct construct NN cord-015021-pol2qm74 3382 10 carrying carry VBG cord-015021-pol2qm74 3382 11 the the DT cord-015021-pol2qm74 3382 12 human human NN cord-015021-pol2qm74 3382 13 ( ( -LRB- cord-015021-pol2qm74 3382 14 hu hu NNP cord-015021-pol2qm74 3382 15 ) ) -RRB- cord-015021-pol2qm74 3382 16 e e LS cord-015021-pol2qm74 3382 17 - - HYPH cord-015021-pol2qm74 3382 18 kit kit NN cord-015021-pol2qm74 3382 19 gena gena NNP cord-015021-pol2qm74 3382 20 , , , cord-015021-pol2qm74 3382 21 exogenous exogenous JJ cord-015021-pol2qm74 3382 22 hu hu NNP cord-015021-pol2qm74 3382 23 KL KL NNP cord-015021-pol2qm74 3383 1 transiently transiently RB cord-015021-pol2qm74 3383 2 down down RB cord-015021-pol2qm74 3383 3 - - HYPH cord-015021-pol2qm74 3383 4 regulated regulate VBN cord-015021-pol2qm74 3383 5 kit kit NN cord-015021-pol2qm74 3383 6 receptors receptor NNS cord-015021-pol2qm74 3383 7 ( ( -LRB- cord-015021-pol2qm74 3383 8 Blume Blume NNP cord-015021-pol2qm74 3383 9 - - HYPH cord-015021-pol2qm74 3383 10 Jeusen Jeusen NNP cord-015021-pol2qm74 3383 11 et et NNP cord-015021-pol2qm74 3383 12 al al NNP cord-015021-pol2qm74 3383 13 . . . cord-015021-pol2qm74 3384 1 1991 1991 CD cord-015021-pol2qm74 3384 2 , , , cord-015021-pol2qm74 3384 3 EMBO EMBO NNP cord-015021-pol2qm74 3384 4 J J NNP cord-015021-pol2qm74 3384 5 10 10 CD cord-015021-pol2qm74 3384 6 : : : cord-015021-pol2qm74 3384 7 4121 4121 CD cord-015021-pol2qm74 3384 8 ) ) -RRB- cord-015021-pol2qm74 3384 9 . . . cord-015021-pol2qm74 3385 1 In in IN cord-015021-pol2qm74 3385 2 the the DT cord-015021-pol2qm74 3385 3 light light NN cord-015021-pol2qm74 3385 4 of of IN cord-015021-pol2qm74 3385 5 these these DT cord-015021-pol2qm74 3385 6 previous previous JJ cord-015021-pol2qm74 3385 7 findings finding NNS cord-015021-pol2qm74 3385 8 we -PRON- PRP cord-015021-pol2qm74 3385 9 analyzed analyze VBD cord-015021-pol2qm74 3385 10 the the DT cord-015021-pol2qm74 3385 11 effects effect NNS cord-015021-pol2qm74 3385 12 of of IN cord-015021-pol2qm74 3385 13 these these DT cord-015021-pol2qm74 3385 14 exogenously exogenously RB cord-015021-pol2qm74 3385 15 applied apply VBN cord-015021-pol2qm74 3385 16 cytokines cytokine NNS cord-015021-pol2qm74 3385 17 ( ( -LRB- cord-015021-pol2qm74 3385 18 IL-4 IL-4 NNP cord-015021-pol2qm74 3385 19 , , , cord-015021-pol2qm74 3385 20 TGFgl TGFgl NNP cord-015021-pol2qm74 3385 21 , , , cord-015021-pol2qm74 3385 22 KL KL NNP cord-015021-pol2qm74 3385 23 ) ) -RRB- cord-015021-pol2qm74 3385 24 on on IN cord-015021-pol2qm74 3385 25 kit kit NN cord-015021-pol2qm74 3385 26 receptor receptor NN cord-015021-pol2qm74 3385 27 expression expression NN cord-015021-pol2qm74 3385 28 and and CC cord-015021-pol2qm74 3385 29 KL kl NN cord-015021-pol2qm74 3385 30 - - HYPH cord-015021-pol2qm74 3385 31 mediated mediate VBN cord-015021-pol2qm74 3385 32 proliferation proliferation NN cord-015021-pol2qm74 3385 33 and and CC cord-015021-pol2qm74 3385 34 chemotactic chemotactic JJ cord-015021-pol2qm74 3385 35 migration migration NN cord-015021-pol2qm74 3385 36 of of IN cord-015021-pol2qm74 3385 37 primary primary JJ cord-015021-pol2qm74 3385 38 mouse mouse NN cord-015021-pol2qm74 3385 39 bone bone NN cord-015021-pol2qm74 3385 40 marrow marrow NN cord-015021-pol2qm74 3385 41 - - HYPH cord-015021-pol2qm74 3385 42 derived derive VBN cord-015021-pol2qm74 3385 43 mast mast NN cord-015021-pol2qm74 3385 44 cells cell NNS cord-015021-pol2qm74 3385 45 ( ( -LRB- cord-015021-pol2qm74 3385 46 BMMC BMMC NNP cord-015021-pol2qm74 3385 47 ) ) -RRB- cord-015021-pol2qm74 3386 1 ( ( -LRB- cord-015021-pol2qm74 3386 2 in in IN cord-015021-pol2qm74 3386 3 vitro vitro FW cord-015021-pol2qm74 3386 4 age age NN cord-015021-pol2qm74 3386 5 : : : cord-015021-pol2qm74 3386 6 4 4 CD cord-015021-pol2qm74 3386 7 weeks week NNS cord-015021-pol2qm74 3386 8 ) ) -RRB- cord-015021-pol2qm74 3386 9 . . . cord-015021-pol2qm74 3387 1 Our -PRON- PRP$ cord-015021-pol2qm74 3387 2 results result NNS cord-015021-pol2qm74 3387 3 show show VBP cord-015021-pol2qm74 3387 4 that that IN cord-015021-pol2qm74 3387 5 in in IN cord-015021-pol2qm74 3387 6 BMMC BMMC NNP cord-015021-pol2qm74 3387 7 cultures culture NNS cord-015021-pol2qm74 3387 8 initiated initiate VBN cord-015021-pol2qm74 3387 9 with with IN cord-015021-pol2qm74 3387 10 recombinant recombinant JJ cord-015021-pol2qm74 3387 11 ( ( -LRB- cord-015021-pol2qm74 3387 12 r r NN cord-015021-pol2qm74 3387 13 ) ) -RRB- cord-015021-pol2qm74 3387 14 marine marine JJ cord-015021-pol2qm74 3387 15 ( ( -LRB- cord-015021-pol2qm74 3387 16 mu mu NN cord-015021-pol2qm74 3387 17 ) ) -RRB- cord-015021-pol2qm74 3388 1 IL-3 IL-3 NNP cord-015021-pol2qm74 3389 1 the the DT cord-015021-pol2qm74 3389 2 additional additional JJ cord-015021-pol2qm74 3389 3 presence presence NN cord-015021-pol2qm74 3389 4 of of IN cord-015021-pol2qm74 3389 5 rmulL-4 rmulL-4 NNP cord-015021-pol2qm74 3389 6 for for IN cord-015021-pol2qm74 3389 7 3 3 CD cord-015021-pol2qm74 3389 8 or or CC cord-015021-pol2qm74 3389 9 14 14 CD cord-015021-pol2qm74 3389 10 days day NNS cord-015021-pol2qm74 3389 11 did do VBD cord-015021-pol2qm74 3389 12 not not RB cord-015021-pol2qm74 3389 13 change change VB cord-015021-pol2qm74 3389 14 the the DT cord-015021-pol2qm74 3389 15 expression expression NN cord-015021-pol2qm74 3389 16 of of IN cord-015021-pol2qm74 3389 17 kit kit NN cord-015021-pol2qm74 3389 18 protein protein NN cord-015021-pol2qm74 3389 19 ( ( -LRB- cord-015021-pol2qm74 3389 20 assessed assess VBN cord-015021-pol2qm74 3389 21 by by IN cord-015021-pol2qm74 3389 22 FACS FACS NNP cord-015021-pol2qm74 3389 23 analysis analysis NN cord-015021-pol2qm74 3389 24 with with IN cord-015021-pol2qm74 3389 25 the the DT cord-015021-pol2qm74 3389 26 anti anti JJ cord-015021-pol2qm74 3389 27 - - JJ cord-015021-pol2qm74 3389 28 mouse mouse JJ cord-015021-pol2qm74 3389 29 c c NNP cord-015021-pol2qm74 3389 30 - - HYPH cord-015021-pol2qm74 3389 31 kit kit NN cord-015021-pol2qm74 3389 32 antibody antibody NN cord-015021-pol2qm74 3389 33 ACK-2 ACK-2 NNP cord-015021-pol2qm74 3389 34 ) ) -RRB- cord-015021-pol2qm74 3389 35 nor nor CC cord-015021-pol2qm74 3389 36 KL kl NN cord-015021-pol2qm74 3389 37 - - HYPH cord-015021-pol2qm74 3389 38 mediated mediate VBN cord-015021-pol2qm74 3389 39 proliferation proliferation NN cord-015021-pol2qm74 3389 40 or or CC cord-015021-pol2qm74 3389 41 chemotaxis chemotaxis NN cord-015021-pol2qm74 3389 42 . . . cord-015021-pol2qm74 3390 1 In in IN cord-015021-pol2qm74 3390 2 contrast contrast NN cord-015021-pol2qm74 3390 3 , , , cord-015021-pol2qm74 3390 4 IL-4 IL-4 NNP cord-015021-pol2qm74 3390 5 syeergistically syeergistically RB cord-015021-pol2qm74 3390 6 increased increase VBD cord-015021-pol2qm74 3390 7 KL KL NNP cord-015021-pol2qm74 3390 8 - - HYPH cord-015021-pol2qm74 3390 9 stimulated stimulate VBN cord-015021-pol2qm74 3390 10 growth growth NN cord-015021-pol2qm74 3390 11 of of IN cord-015021-pol2qm74 3390 12 BMMC BMMC NNP cord-015021-pol2qm74 3390 13 in in IN cord-015021-pol2qm74 3390 14 a a DT cord-015021-pol2qm74 3390 15 short short JJ cord-015021-pol2qm74 3390 16 - - HYPH cord-015021-pol2qm74 3390 17 term term NN cord-015021-pol2qm74 3390 18 proliferation proliferation NN cord-015021-pol2qm74 3390 19 assay assay NN cord-015021-pol2qm74 3390 20 ( ( -LRB- cord-015021-pol2qm74 3390 21 MTT MTT NNP cord-015021-pol2qm74 3390 22 - - HYPH cord-015021-pol2qm74 3390 23 tes0 tes0 NN cord-015021-pol2qm74 3390 24 . . . cord-015021-pol2qm74 3391 1 Pre pre JJ cord-015021-pol2qm74 3391 2 - - NN cord-015021-pol2qm74 3391 3 incubation incubation NN cord-015021-pol2qm74 3391 4 of of IN cord-015021-pol2qm74 3391 5 BMMC BMMC NNP cord-015021-pol2qm74 3391 6 with with IN cord-015021-pol2qm74 3391 7 rhuTGFl~ rhuTGFl~ NNS cord-015021-pol2qm74 3391 8 1 1 CD cord-015021-pol2qm74 3391 9 ( ( -LRB- cord-015021-pol2qm74 3391 10 5.0 5.0 CD cord-015021-pol2qm74 3391 11 , , , cord-015021-pol2qm74 3391 12 1.0 1.0 CD cord-015021-pol2qm74 3391 13 , , , cord-015021-pol2qm74 3391 14 or or CC cord-015021-pol2qm74 3391 15 0.1 0.1 CD cord-015021-pol2qm74 3391 16 ng ng NN cord-015021-pol2qm74 3391 17 / / SYM cord-015021-pol2qm74 3391 18 ml ml NN cord-015021-pol2qm74 3391 19 ) ) -RRB- cord-015021-pol2qm74 3391 20 for for IN cord-015021-pol2qm74 3391 21 24h 24h NNS cord-015021-pol2qm74 3391 22 had have VBD cord-015021-pol2qm74 3391 23 no no DT cord-015021-pol2qm74 3391 24 effect effect NN cord-015021-pol2qm74 3391 25 on on IN cord-015021-pol2qm74 3391 26 kit kit NN cord-015021-pol2qm74 3391 27 receptor receptor NN cord-015021-pol2qm74 3391 28 expression expression NN cord-015021-pol2qm74 3391 29 , , , cord-015021-pol2qm74 3391 30 although although IN cord-015021-pol2qm74 3391 31 TGFfil TGFfil NNP cord-015021-pol2qm74 3391 32 at at IN cord-015021-pol2qm74 3391 33 concentrations concentration NNS cord-015021-pol2qm74 3391 34 of of IN cord-015021-pol2qm74 3391 35 0.5 0.5 CD cord-015021-pol2qm74 3391 36 -5.0 -5.0 CD cord-015021-pol2qm74 3391 37 ng ng NN cord-015021-pol2qm74 3391 38 / / SYM cord-015021-pol2qm74 3391 39 ml ml XX cord-015021-pol2qm74 3391 40 completely completely RB cord-015021-pol2qm74 3391 41 suppressed suppress VBD cord-015021-pol2qm74 3391 42 the the DT cord-015021-pol2qm74 3391 43 proliferative proliferative JJ cord-015021-pol2qm74 3391 44 action action NN cord-015021-pol2qm74 3391 45 of of IN cord-015021-pol2qm74 3391 46 KL KL NNP cord-015021-pol2qm74 3391 47 on on IN cord-015021-pol2qm74 3391 48 these these DT cord-015021-pol2qm74 3391 49 ceils ceil NNS cord-015021-pol2qm74 3391 50 . . . cord-015021-pol2qm74 3392 1 Similar similar JJ cord-015021-pol2qm74 3392 2 anti anti JJ cord-015021-pol2qm74 3392 3 - - JJ cord-015021-pol2qm74 3392 4 proliferative proliferative JJ cord-015021-pol2qm74 3392 5 effects effect NNS cord-015021-pol2qm74 3392 6 of of IN cord-015021-pol2qm74 3392 7 TGFg TGFg NNS cord-015021-pol2qm74 3392 8 1 1 CD cord-015021-pol2qm74 3392 9 were be VBD cord-015021-pol2qm74 3392 10 observed observe VBN cord-015021-pol2qm74 3392 11 in in IN cord-015021-pol2qm74 3392 12 various various JJ cord-015021-pol2qm74 3392 13 factor factor NN cord-015021-pol2qm74 3392 14 - - HYPH cord-015021-pol2qm74 3392 15 dependent dependent JJ cord-015021-pol2qm74 3392 16 mast mast JJ cord-015021-pol2qm74 3392 17 cell cell NN cord-015021-pol2qm74 3392 18 lines line NNS cord-015021-pol2qm74 3392 19 stimulated stimulate VBN cord-015021-pol2qm74 3392 20 with with IN cord-015021-pol2qm74 3392 21 different different JJ cord-015021-pol2qm74 3392 22 mast mast JJ cord-015021-pol2qm74 3392 23 cell cell NN cord-015021-pol2qm74 3392 24 growth growth NN cord-015021-pol2qm74 3392 25 factors factor NNS cord-015021-pol2qm74 3392 26 ( ( -LRB- cord-015021-pol2qm74 3392 27 IL-3 IL-3 NNP cord-015021-pol2qm74 3392 28 , , , cord-015021-pol2qm74 3392 29 1I,-4 1i,-4 CD cord-015021-pol2qm74 3392 30 , , , cord-015021-pol2qm74 3392 31 IL-9 IL-9 NNP cord-015021-pol2qm74 3392 32 , , , cord-015021-pol2qm74 3392 33 and/or and/or CC cord-015021-pol2qm74 3392 34 IL-10 IL-10 NNP cord-015021-pol2qm74 3392 35 ) ) -RRB- cord-015021-pol2qm74 3392 36 . . . cord-015021-pol2qm74 3393 1 Moreover moreover RB cord-015021-pol2qm74 3393 2 , , , cord-015021-pol2qm74 3393 3 pre pre JJ cord-015021-pol2qm74 3393 4 - - JJ cord-015021-pol2qm74 3393 5 incuhation incuhation JJ cord-015021-pol2qm74 3393 6 ( ( -LRB- cord-015021-pol2qm74 3393 7 24h 24h NNS cord-015021-pol2qm74 3393 8 ) ) -RRB- cord-015021-pol2qm74 3393 9 of of IN cord-015021-pol2qm74 3393 10 BMMC BMMC NNP cord-015021-pol2qm74 3393 11 with with IN cord-015021-pol2qm74 3393 12 TGF TGF NNP cord-015021-pol2qm74 3393 13 - - HYPH cord-015021-pol2qm74 3393 14 gl gl NNP cord-015021-pol2qm74 3393 15 ( ( -LRB- cord-015021-pol2qm74 3393 16 > > NFP cord-015021-pol2qm74 3393 17 500 500 CD cord-015021-pol2qm74 3393 18 pg pg NN cord-015021-pol2qm74 3393 19 / / SYM cord-015021-pol2qm74 3393 20 ml ml NN cord-015021-pol2qm74 3393 21 ) ) -RRB- cord-015021-pol2qm74 3393 22 significantly significantly RB cord-015021-pol2qm74 3393 23 enhanced enhance VBD cord-015021-pol2qm74 3393 24 spontaneous spontaneous JJ cord-015021-pol2qm74 3393 25 undirected undirected JJ cord-015021-pol2qm74 3393 26 cell cell NN cord-015021-pol2qm74 3393 27 movement movement NN cord-015021-pol2qm74 3393 28 ( ( -LRB- cord-015021-pol2qm74 3393 29 chemokinesis chemokinesis NNP cord-015021-pol2qm74 3393 30 ) ) -RRB- cord-015021-pol2qm74 3393 31 and and CC cord-015021-pol2qm74 3393 32 synergistically synergistically RB cord-015021-pol2qm74 3393 33 increased increase VBD cord-015021-pol2qm74 3393 34 IL-3-or IL-3-or NNP cord-015021-pol2qm74 3393 35 KL KL NNP cord-015021-pol2qm74 3393 36 - - HYPH cord-015021-pol2qm74 3393 37 induced induce VBN cord-015021-pol2qm74 3393 38 chemetaxis chemetaxis NNP cord-015021-pol2qm74 3393 39 . . . cord-015021-pol2qm74 3394 1 When when WRB cord-015021-pol2qm74 3394 2 BMMC BMMC NNP cord-015021-pol2qm74 3394 3 were be VBD cord-015021-pol2qm74 3394 4 preAncuhated preancuhate VBN cord-015021-pol2qm74 3394 5 with with IN cord-015021-pol2qm74 3394 6 rmuKL rmuKL NNP cord-015021-pol2qm74 3394 7 ( ( -LRB- cord-015021-pol2qm74 3394 8 200 200 CD cord-015021-pol2qm74 3394 9 ng ng NN cord-015021-pol2qm74 3394 10 / / SYM cord-015021-pol2qm74 3394 11 ml ml NN cord-015021-pol2qm74 3394 12 ) ) -RRB- cord-015021-pol2qm74 3394 13 for for IN cord-015021-pol2qm74 3394 14 1 1 CD cord-015021-pol2qm74 3394 15 , , , cord-015021-pol2qm74 3394 16 3 3 CD cord-015021-pol2qm74 3394 17 . . NN cord-015021-pol2qm74 3394 18 or or CC cord-015021-pol2qm74 3394 19 5 5 CD cord-015021-pol2qm74 3394 20 days day NNS cord-015021-pol2qm74 3394 21 , , , cord-015021-pol2qm74 3394 22 a a DT cord-015021-pol2qm74 3394 23 transient transient JJ cord-015021-pol2qm74 3394 24 down down NN cord-015021-pol2qm74 3394 25 - - HYPH cord-015021-pol2qm74 3394 26 modulation modulation NN cord-015021-pol2qm74 3394 27 of of IN cord-015021-pol2qm74 3394 28 kit kit NN cord-015021-pol2qm74 3394 29 receptors receptor NNS cord-015021-pol2qm74 3394 30 with with IN cord-015021-pol2qm74 3394 31 a a DT cord-015021-pol2qm74 3394 32 maximum maximum JJ cord-015021-pol2qm74 3394 33 effect effect NN cord-015021-pol2qm74 3394 34 on on IN cord-015021-pol2qm74 3394 35 day day NN cord-015021-pol2qm74 3394 36 1 1 CD cord-015021-pol2qm74 3394 37 was be VBD cord-015021-pol2qm74 3394 38 demonstrated demonstrate VBN cord-015021-pol2qm74 3394 39 by by IN cord-015021-pol2qm74 3394 40 FACS FACS NNP cord-015021-pol2qm74 3394 41 analysis analysis NN cord-015021-pol2qm74 3394 42 and and CC cord-015021-pol2qm74 3394 43 correlated correlate VBD cord-015021-pol2qm74 3394 44 well well RB cord-015021-pol2qm74 3394 45 with with IN cord-015021-pol2qm74 3394 46 a a DT cord-015021-pol2qm74 3394 47 decreased decrease VBN cord-015021-pol2qm74 3394 48 chemotactic chemotactic JJ cord-015021-pol2qm74 3394 49 response response NN cord-015021-pol2qm74 3394 50 of of IN cord-015021-pol2qm74 3394 51 these these DT cord-015021-pol2qm74 3394 52 cells cell NNS cord-015021-pol2qm74 3394 53 . . . cord-015021-pol2qm74 3395 1 In in IN cord-015021-pol2qm74 3395 2 conclusion conclusion NN cord-015021-pol2qm74 3395 3 our -PRON- PRP$ cord-015021-pol2qm74 3395 4 results result NNS cord-015021-pol2qm74 3395 5 show show VBP cord-015021-pol2qm74 3395 6 that that IN cord-015021-pol2qm74 3395 7 neither neither CC cord-015021-pol2qm74 3395 8 IL-4 IL-4 NNP cord-015021-pol2qm74 3395 9 nor nor CC cord-015021-pol2qm74 3395 10 TGFI31 TGFI31 NNP cord-015021-pol2qm74 3395 11 affect affect VB cord-015021-pol2qm74 3395 12 expression expression NN cord-015021-pol2qm74 3395 13 of of IN cord-015021-pol2qm74 3395 14 kit kit NN cord-015021-pol2qm74 3395 15 receptors receptor NNS cord-015021-pol2qm74 3395 16 in in IN cord-015021-pol2qm74 3395 17 primary primary JJ cord-015021-pol2qm74 3395 18 murine murine JJ cord-015021-pol2qm74 3395 19 BMMC BMMC NNP cord-015021-pol2qm74 3395 20 . . . cord-015021-pol2qm74 3396 1 It -PRON- PRP cord-015021-pol2qm74 3396 2 is be VBZ cord-015021-pol2qm74 3396 3 reasonable reasonable JJ cord-015021-pol2qm74 3396 4 to to TO cord-015021-pol2qm74 3396 5 suggest suggest VB cord-015021-pol2qm74 3396 6 that that IN cord-015021-pol2qm74 3396 7 c c NN cord-015021-pol2qm74 3396 8 - - HYPH cord-015021-pol2qm74 3396 9 kit kit NN cord-015021-pol2qm74 3396 10 expression expression NN cord-015021-pol2qm74 3396 11 is be VBZ cord-015021-pol2qm74 3396 12 controlled control VBN cord-015021-pol2qm74 3396 13 in in IN cord-015021-pol2qm74 3396 14 a a DT cord-015021-pol2qm74 3396 15 cell cell NN cord-015021-pol2qm74 3396 16 type type NN cord-015021-pol2qm74 3396 17 - - HYPH cord-015021-pol2qm74 3396 18 specific specific JJ cord-015021-pol2qm74 3396 19 manner manner NN cord-015021-pol2qm74 3396 20 . . . cord-015021-pol2qm74 3397 1 Interestingly interestingly RB cord-015021-pol2qm74 3397 2 , , , cord-015021-pol2qm74 3397 3 TGFgl TGFgl NNP cord-015021-pol2qm74 3397 4 is be VBZ cord-015021-pol2qm74 3397 5 obviously obviously RB cord-015021-pol2qm74 3397 6 able able JJ cord-015021-pol2qm74 3397 7 to to TO cord-015021-pol2qm74 3397 8 dissect dissect VB cord-015021-pol2qm74 3397 9 the the DT cord-015021-pol2qm74 3397 10 proliferative proliferative NN cord-015021-pol2qm74 3397 11 from from IN cord-015021-pol2qm74 3397 12 the the DT cord-015021-pol2qm74 3397 13 migrational migrational JJ cord-015021-pol2qm74 3397 14 signal signal NN cord-015021-pol2qm74 3397 15 transducted transducte VBN cord-015021-pol2qm74 3397 16 by by IN cord-015021-pol2qm74 3397 17 KL KL NNP cord-015021-pol2qm74 3397 18 in in IN cord-015021-pol2qm74 3397 19 these these DT cord-015021-pol2qm74 3397 20 cells cell NNS cord-015021-pol2qm74 3397 21 . . . cord-015021-pol2qm74 3398 1 Objectives objective NNS cord-015021-pol2qm74 3398 2 of of IN cord-015021-pol2qm74 3398 3 the the DT cord-015021-pol2qm74 3398 4 study study NN cord-015021-pol2qm74 3398 5 : : : cord-015021-pol2qm74 3398 6 Antisense Antisense NNP cord-015021-pol2qm74 3398 7 strategies strategy NNS cord-015021-pol2qm74 3398 8 using use VBG cord-015021-pol2qm74 3398 9 DNA dna NN cord-015021-pol2qm74 3398 10 - - HYPH cord-015021-pol2qm74 3398 11 otigonucleofides otigonucleofide NNS cord-015021-pol2qm74 3398 12 ( ( -LRB- cord-015021-pol2qm74 3398 13 ODN ODN NNP cord-015021-pol2qm74 3398 14 ) ) -RRB- cord-015021-pol2qm74 3398 15 to to TO cord-015021-pol2qm74 3398 16 modulate modulate VB cord-015021-pol2qm74 3398 17 the the DT cord-015021-pol2qm74 3398 18 cytokine cytokine NN cord-015021-pol2qm74 3398 19 response response NN cord-015021-pol2qm74 3398 20 are be VBP cord-015021-pol2qm74 3398 21 presently presently RB cord-015021-pol2qm74 3398 22 under under IN cord-015021-pol2qm74 3398 23 investigation investigation NN cord-015021-pol2qm74 3398 24 . . . cord-015021-pol2qm74 3399 1 ODN ODN NNP cord-015021-pol2qm74 3399 2 are be VBP cord-015021-pol2qm74 3399 3 thought think VBN cord-015021-pol2qm74 3399 4 to to TO cord-015021-pol2qm74 3399 5 act act VB cord-015021-pol2qm74 3399 6 very very RB cord-015021-pol2qm74 3399 7 specifically specifically RB cord-015021-pol2qm74 3399 8 with with IN cord-015021-pol2qm74 3399 9 little little JJ cord-015021-pol2qm74 3399 10 or or CC cord-015021-pol2qm74 3399 11 no no DT cord-015021-pol2qm74 3399 12 relevant relevant JJ cord-015021-pol2qm74 3399 13 negative negative JJ cord-015021-pol2qm74 3399 14 side side NN cord-015021-pol2qm74 3399 15 effects effect NNS cord-015021-pol2qm74 3399 16 . . . cord-015021-pol2qm74 3400 1 We -PRON- PRP cord-015021-pol2qm74 3400 2 now now RB cord-015021-pol2qm74 3400 3 report report VBP cord-015021-pol2qm74 3400 4 that that IN cord-015021-pol2qm74 3400 5 ODN ODN NNP cord-015021-pol2qm74 3400 6 unspeeifically unspeeifically RB cord-015021-pol2qm74 3400 7 protect protect VB cord-015021-pol2qm74 3400 8 WEHI WEHI NNP cord-015021-pol2qm74 3400 9 164 164 CD cord-015021-pol2qm74 3400 10 cells cell NNS cord-015021-pol2qm74 3400 11 from from IN cord-015021-pol2qm74 3400 12 TNF TNF NNP cord-015021-pol2qm74 3400 13 - - HYPH cord-015021-pol2qm74 3400 14 mediated mediate VBN cord-015021-pol2qm74 3400 15 cytolysis cytolysis NN cord-015021-pol2qm74 3400 16 . . . cord-015021-pol2qm74 3401 1 Material material NN cord-015021-pol2qm74 3401 2 and and CC cord-015021-pol2qm74 3401 3 Methods method NNS cord-015021-pol2qm74 3401 4 : : : cord-015021-pol2qm74 3401 5 WEHI WEHI NNP cord-015021-pol2qm74 3401 6 164 164 CD cord-015021-pol2qm74 3401 7 subclone subclone VBD cord-015021-pol2qm74 3401 8 13 13 CD cord-015021-pol2qm74 3401 9 ceils ceil NNS cord-015021-pol2qm74 3401 10 ( ( -LRB- cord-015021-pol2qm74 3401 11 5 5 CD cord-015021-pol2qm74 3401 12 x x SYM cord-015021-pol2qm74 3401 13 105 105 CD cord-015021-pol2qm74 3401 14 ) ) -RRB- cord-015021-pol2qm74 3402 1 , , , cord-015021-pol2qm74 3402 2 that that WDT cord-015021-pol2qm74 3402 3 are be VBP cord-015021-pol2qm74 3402 4 highly highly RB cord-015021-pol2qm74 3402 5 sensitive sensitive JJ cord-015021-pol2qm74 3402 6 to to IN cord-015021-pol2qm74 3402 7 the the DT cord-015021-pol2qm74 3402 8 cytolytic cytolytic JJ cord-015021-pol2qm74 3402 9 activity activity NN cord-015021-pol2qm74 3402 10 of of IN cord-015021-pol2qm74 3402 11 TNF TNF NNP cord-015021-pol2qm74 3402 12 , , , cord-015021-pol2qm74 3402 13 were be VBD cord-015021-pol2qm74 3402 14 grown grow VBN cord-015021-pol2qm74 3402 15 on on IN cord-015021-pol2qm74 3402 16 96-well 96-well CD cord-015021-pol2qm74 3402 17 culture culture NN cord-015021-pol2qm74 3402 18 plates plate NNS cord-015021-pol2qm74 3402 19 in in IN cord-015021-pol2qm74 3402 20 RPM11640 RPM11640 NNP cord-015021-pol2qm74 3402 21 medium medium NN cord-015021-pol2qm74 3402 22 . . . cord-015021-pol2qm74 3403 1 After after IN cord-015021-pol2qm74 3403 2 24 24 CD cord-015021-pol2qm74 3403 3 hours hour NNS cord-015021-pol2qm74 3403 4 , , , cord-015021-pol2qm74 3403 5 phosphorothioate(PS)and phosphorothioate(ps)and NN cord-015021-pol2qm74 3403 6 partially partially RB cord-015021-pol2qm74 3403 7 PS ps NN cord-015021-pol2qm74 3403 8 - - HYPH cord-015021-pol2qm74 3403 9 modified modify VBN cord-015021-pol2qm74 3403 10 - - HYPH cord-015021-pol2qm74 3403 11 ODN odn NN cord-015021-pol2qm74 3403 12 as as RB cord-015021-pol2qm74 3403 13 well well RB cord-015021-pol2qm74 3403 14 as as IN cord-015021-pol2qm74 3403 15 phesphodiester phesphodiester JJ cord-015021-pol2qm74 3403 16 - - HYPH cord-015021-pol2qm74 3403 17 ODN ODN NNP cord-015021-pol2qm74 3403 18 ( ( -LRB- cord-015021-pol2qm74 3403 19 20 20 CD cord-015021-pol2qm74 3403 20 - - HYPH cord-015021-pol2qm74 3403 21 29bp 29bp CD cord-015021-pol2qm74 3403 22 ) ) -RRB- cord-015021-pol2qm74 3403 23 were be VBD cord-015021-pol2qm74 3403 24 added add VBN cord-015021-pol2qm74 3403 25 ( ( -LRB- cord-015021-pol2qm74 3403 26 0.1 0.1 CD cord-015021-pol2qm74 3403 27 , , , cord-015021-pol2qm74 3403 28 1 1 CD cord-015021-pol2qm74 3403 29 and and CC cord-015021-pol2qm74 3403 30 10 10 CD cord-015021-pol2qm74 3403 31 pM pm NN cord-015021-pol2qm74 3403 32 ) ) -RRB- cord-015021-pol2qm74 3403 33 . . . cord-015021-pol2qm74 3404 1 Four four CD cord-015021-pol2qm74 3404 2 hours hour NNS cord-015021-pol2qm74 3404 3 after after IN cord-015021-pol2qm74 3404 4 incubation incubation NN cord-015021-pol2qm74 3404 5 with with IN cord-015021-pol2qm74 3404 6 ODN ODN NNP cord-015021-pol2qm74 3404 7 , , , cord-015021-pol2qm74 3404 8 ce(I ce(i NN cord-015021-pol2qm74 3404 9 lysis lysis NN cord-015021-pol2qm74 3404 10 was be VBD cord-015021-pol2qm74 3404 11 induced induce VBN cord-015021-pol2qm74 3404 12 by by IN cord-015021-pol2qm74 3404 13 recombinant recombinant JJ cord-015021-pol2qm74 3404 14 murina murina NNP cord-015021-pol2qm74 3404 15 TNF TNF NNP cord-015021-pol2qm74 3404 16 . . . cord-015021-pol2qm74 3405 1 After after IN cord-015021-pol2qm74 3405 2 18 18 CD cord-015021-pol2qm74 3405 3 hours hour NNS cord-015021-pol2qm74 3405 4 the the DT cord-015021-pol2qm74 3405 5 plates plate NNS cord-015021-pol2qm74 3405 6 were be VBD cord-015021-pol2qm74 3405 7 washed wash VBN cord-015021-pol2qm74 3405 8 and and CC cord-015021-pol2qm74 3405 9 stained stain VBN cord-015021-pol2qm74 3405 10 with with IN cord-015021-pol2qm74 3405 11 crystal crystal JJ cord-015021-pol2qm74 3405 12 violet violet NN cord-015021-pol2qm74 3405 13 Cell Cell NNP cord-015021-pol2qm74 3405 14 lysis lysis NN cord-015021-pol2qm74 3405 15 was be VBD cord-015021-pol2qm74 3405 16 determined determine VBN cord-015021-pol2qm74 3405 17 by by IN cord-015021-pol2qm74 3405 18 reading read VBG cord-015021-pol2qm74 3405 19 the the DT cord-015021-pol2qm74 3405 20 absorbance absorbance NN cord-015021-pol2qm74 3405 21 ( ( -LRB- cord-015021-pol2qm74 3405 22 ABS abs NN cord-015021-pol2qm74 3405 23 ) ) -RRB- cord-015021-pol2qm74 3405 24 at at IN cord-015021-pol2qm74 3405 25 590 590 CD cord-015021-pol2qm74 3405 26 nm nm NN cord-015021-pol2qm74 3405 27 . . . cord-015021-pol2qm74 3406 1 Results result NNS cord-015021-pol2qm74 3406 2 : : : cord-015021-pol2qm74 3407 1 WEHI WEHI NNP cord-015021-pol2qm74 3407 2 164 164 CD cord-015021-pol2qm74 3407 3 ceils ceil NNS cord-015021-pol2qm74 3407 4 incubated incubate VBN cord-015021-pol2qm74 3407 5 with with IN cord-015021-pol2qm74 3407 6 TNF TNF NNP cord-015021-pol2qm74 3407 7 ( ( -LRB- cord-015021-pol2qm74 3407 8 1 1 CD cord-015021-pol2qm74 3407 9 - - HYPH cord-015021-pol2qm74 3407 10 8ng 8ng NN cord-015021-pol2qm74 3407 11 / / SYM cord-015021-pol2qm74 3407 12 ml ml NN cord-015021-pol2qm74 3407 13 ) ) -RRB- cord-015021-pol2qm74 3407 14 were be VBD cord-015021-pol2qm74 3407 15 completely completely RB cord-015021-pol2qm74 3407 16 lysed lyse VBN cord-015021-pol2qm74 3407 17 after after IN cord-015021-pol2qm74 3407 18 18 18 CD cord-015021-pol2qm74 3407 19 hours hour NNS cord-015021-pol2qm74 3407 20 ( ( -LRB- cord-015021-pol2qm74 3407 21 0 0 CD cord-015021-pol2qm74 3407 22 % % NN cord-015021-pol2qm74 3407 23 ABS abs NN cord-015021-pol2qm74 3407 24 ) ) -RRB- cord-015021-pol2qm74 3407 25 . . . cord-015021-pol2qm74 3408 1 Interestingly interestingly RB cord-015021-pol2qm74 3408 2 , , , cord-015021-pol2qm74 3408 3 WEHI WEHI NNP cord-015021-pol2qm74 3408 4 cells cell NNS cord-015021-pol2qm74 3408 5 incubated incubate VBN cord-015021-pol2qm74 3408 6 with with IN cord-015021-pol2qm74 3408 7 TNF TNF NNP cord-015021-pol2qm74 3408 8 and and CC cord-015021-pol2qm74 3408 9 ODN ODN NNP cord-015021-pol2qm74 3408 10 resisted resist VBD cord-015021-pol2qm74 3408 11 complete complete JJ cord-015021-pol2qm74 3408 12 lysis lysis NN cord-015021-pol2qm74 3408 13 , , , cord-015021-pol2qm74 3408 14 eg eg IN cord-015021-pol2qm74 3408 15 cells cell NNS cord-015021-pol2qm74 3408 16 incubated incubate VBN cord-015021-pol2qm74 3408 17 with with IN cord-015021-pol2qm74 3408 18 2.5ng 2.5ng CD cord-015021-pol2qm74 3408 19 / / SYM cord-015021-pol2qm74 3408 20 ml ml NN cord-015021-pol2qm74 3408 21 TNF TNF NNP cord-015021-pol2qm74 3408 22 and and CC cord-015021-pol2qm74 3408 23 11JM 11jm CD cord-015021-pol2qm74 3408 24 ODN ODN NNP cord-015021-pol2qm74 3408 25 showed show VBD cord-015021-pol2qm74 3408 26 still still RB cord-015021-pol2qm74 3408 27 30 30 CD cord-015021-pol2qm74 3408 28 % % NN cord-015021-pol2qm74 3408 29 of of IN cord-015021-pol2qm74 3408 30 the the DT cord-015021-pol2qm74 3408 31 absorbance absorbance NN cord-015021-pol2qm74 3408 32 observed observe VBN cord-015021-pol2qm74 3408 33 in in IN cord-015021-pol2qm74 3408 34 control control NN cord-015021-pol2qm74 3408 35 ceils ceil NNS cord-015021-pol2qm74 3408 36 without without IN cord-015021-pol2qm74 3408 37 TNF TNF NNP cord-015021-pol2qm74 3408 38 ( ( -LRB- cord-015021-pol2qm74 3408 39 100 100 CD cord-015021-pol2qm74 3408 40 % % NN cord-015021-pol2qm74 3408 41 ABS abs NN cord-015021-pol2qm74 3408 42 ) ) -RRB- cord-015021-pol2qm74 3408 43 . . . cord-015021-pol2qm74 3409 1 The the DT cord-015021-pol2qm74 3409 2 protective protective JJ cord-015021-pol2qm74 3409 3 effect effect NN cord-015021-pol2qm74 3409 4 of of IN cord-015021-pol2qm74 3409 5 ODN ODN NNP cord-015021-pol2qm74 3409 6 started start VBD cord-015021-pol2qm74 3409 7 at at IN cord-015021-pol2qm74 3409 8 0.1pM 0.1pm CD cord-015021-pol2qm74 3409 9 , , , cord-015021-pol2qm74 3409 10 reached reach VBD cord-015021-pol2qm74 3409 11 a a DT cord-015021-pol2qm74 3409 12 maximum maximum NN cord-015021-pol2qm74 3409 13 at at IN cord-015021-pol2qm74 3409 14 1,uM 1,um CD cord-015021-pol2qm74 3409 15 , , , cord-015021-pol2qm74 3409 16 and and CC cord-015021-pol2qm74 3409 17 diminished diminish VBD cord-015021-pol2qm74 3409 18 at at IN cord-015021-pol2qm74 3409 19 101JM 101JM NNP cord-015021-pol2qm74 3409 20 . . . cord-015021-pol2qm74 3410 1 With with IN cord-015021-pol2qm74 3410 2 increasing increase VBG cord-015021-pol2qm74 3410 3 amounts amount NNS cord-015021-pol2qm74 3410 4 of of IN cord-015021-pol2qm74 3410 5 TNF TNF NNP cord-015021-pol2qm74 3410 6 the the DT cord-015021-pol2qm74 3410 7 protective protective JJ cord-015021-pol2qm74 3410 8 effect effect NN cord-015021-pol2qm74 3410 9 of of IN cord-015021-pol2qm74 3410 10 QDN QDN NNP cord-015021-pol2qm74 3410 11 decreased decrease VBD cord-015021-pol2qm74 3410 12 and and CC cord-015021-pol2qm74 3410 13 no no DT cord-015021-pol2qm74 3410 14 protection protection NN cord-015021-pol2qm74 3410 15 was be VBD cord-015021-pol2qm74 3410 16 detectable detectable JJ cord-015021-pol2qm74 3410 17 at at IN cord-015021-pol2qm74 3410 18 8ng 8ng NNP cord-015021-pol2qm74 3410 19 TNF TNF NNP cord-015021-pol2qm74 3410 20 per per IN cord-015021-pol2qm74 3410 21 ml ml NNP cord-015021-pol2qm74 3410 22 Conclusions conclusion NNS cord-015021-pol2qm74 3410 23 : : : cord-015021-pol2qm74 3411 1 DNA dna NN cord-015021-pol2qm74 3411 2 - - HYPH cord-015021-pol2qm74 3411 3 oligonucleotides oligonucleotide NNS cord-015021-pol2qm74 3411 4 were be VBD cord-015021-pol2qm74 3411 5 found find VBN cord-015021-pol2qm74 3411 6 to to TO cord-015021-pol2qm74 3411 7 unspecifically unspecifically RB cord-015021-pol2qm74 3411 8 inhibit inhibit VB cord-015021-pol2qm74 3411 9 TNF TNF NNP cord-015021-pol2qm74 3411 10 - - HYPH cord-015021-pol2qm74 3411 11 induced induce VBN cord-015021-pol2qm74 3411 12 cytolysis cytolysis NNP cord-015021-pol2qm74 3411 13 . . . cord-015021-pol2qm74 3412 1 We -PRON- PRP cord-015021-pol2qm74 3412 2 hypothesize hypothesize VBP cord-015021-pol2qm74 3412 3 , , , cord-015021-pol2qm74 3412 4 that that IN cord-015021-pol2qm74 3412 5 this this DT cord-015021-pol2qm74 3412 6 protective protective JJ cord-015021-pol2qm74 3412 7 effect effect NN cord-015021-pol2qm74 3412 8 of of IN cord-015021-pol2qm74 3412 9 QDN QDN NNP cord-015021-pol2qm74 3412 10 results result VBZ cord-015021-pol2qm74 3412 11 from from IN cord-015021-pol2qm74 3412 12 an an DT cord-015021-pol2qm74 3412 13 inhibition inhibition NN cord-015021-pol2qm74 3412 14 of of IN cord-015021-pol2qm74 3412 15 the the DT cord-015021-pol2qm74 3412 16 binding binding NN cord-015021-pol2qm74 3412 17 of of IN cord-015021-pol2qm74 3412 18 TNF TNF NNP cord-015021-pol2qm74 3412 19 to to IN cord-015021-pol2qm74 3412 20 its -PRON- PRP$ cord-015021-pol2qm74 3412 21 receptor receptor NN cord-015021-pol2qm74 3412 22 , , , cord-015021-pol2qm74 3412 23 or or CC cord-015021-pol2qm74 3412 24 from from IN cord-015021-pol2qm74 3412 25 interference interference NN cord-015021-pol2qm74 3412 26 of of IN cord-015021-pol2qm74 3412 27 ODN ODN NNP cord-015021-pol2qm74 3412 28 with with IN cord-015021-pol2qm74 3412 29 the the DT cord-015021-pol2qm74 3412 30 subsequent subsequent JJ cord-015021-pol2qm74 3412 31 signal signal NN cord-015021-pol2qm74 3412 32 transduction transduction NN cord-015021-pol2qm74 3412 33 mechanisms mechanism NNS cord-015021-pol2qm74 3412 34 . . . cord-015021-pol2qm74 3413 1 As as IN cord-015021-pol2qm74 3413 2 a a DT cord-015021-pol2qm74 3413 3 consequence consequence NN cord-015021-pol2qm74 3413 4 , , , cord-015021-pol2qm74 3413 5 to to TO cord-015021-pol2qm74 3413 6 discriminate discriminate VB cord-015021-pol2qm74 3413 7 the the DT cord-015021-pol2qm74 3413 8 specific specific JJ cord-015021-pol2qm74 3413 9 effect effect NN cord-015021-pol2qm74 3413 10 of of IN cord-015021-pol2qm74 3413 11 ODN ODN NNP cord-015021-pol2qm74 3413 12 in in IN cord-015021-pol2qm74 3413 13 biologic biologic JJ cord-015021-pol2qm74 3413 14 systems system NNS cord-015021-pol2qm74 3413 15 , , , cord-015021-pol2qm74 3413 16 several several JJ cord-015021-pol2qm74 3413 17 control control NN cord-015021-pol2qm74 3413 18 ODN ODN NNP cord-015021-pol2qm74 3413 19 should should MD cord-015021-pol2qm74 3413 20 be be VB cord-015021-pol2qm74 3413 21 used use VBN cord-015021-pol2qm74 3413 22 . . . cord-015021-pol2qm74 3414 1 Secondly secondly RB cord-015021-pol2qm74 3414 2 , , , cord-015021-pol2qm74 3414 3 whether whether IN cord-015021-pol2qm74 3414 4 DNA dna NN cord-015021-pol2qm74 3414 5 released release VBN cord-015021-pol2qm74 3414 6 by by IN cord-015021-pol2qm74 3414 7 degradation degradation NN cord-015021-pol2qm74 3414 8 of of IN cord-015021-pol2qm74 3414 9 tumor tumor NN cord-015021-pol2qm74 3414 10 cells cell NNS cord-015021-pol2qm74 3414 11 or or CC cord-015021-pol2qm74 3414 12 leukocytes leukocyte NNS cord-015021-pol2qm74 3414 13 can can MD cord-015021-pol2qm74 3414 14 significantly significantly RB cord-015021-pol2qm74 3414 15 impair impair VB cord-015021-pol2qm74 3414 16 tumor tumor NN cord-015021-pol2qm74 3414 17 - - HYPH cord-015021-pol2qm74 3414 18 and and CC cord-015021-pol2qm74 3414 19 immune immune JJ cord-015021-pol2qm74 3414 20 - - HYPH cord-015021-pol2qm74 3414 21 defense defense NN cord-015021-pol2qm74 3414 22 mechanisms mechanism NNS cord-015021-pol2qm74 3414 23 merits merit VBZ cord-015021-pol2qm74 3414 24 further further JJ cord-015021-pol2qm74 3414 25 investigation investigation NN cord-015021-pol2qm74 3414 26 Dr. Dr. NNP cord-015021-pol2qm74 3414 27 med med NNP cord-015021-pol2qm74 3414 28 . . . cord-015021-pol2qm74 3415 1 Michael Michael NNP cord-015021-pol2qm74 3415 2 Meisner Meisner NNP cord-015021-pol2qm74 3415 3 , , , cord-015021-pol2qm74 3415 4 Institut Institut NNP cord-015021-pol2qm74 3415 5 for for IN cord-015021-pol2qm74 3415 6 Anaesthesiologie Anaesthesiologie NNP cord-015021-pol2qm74 3415 7 der der NNP cord-015021-pol2qm74 3415 8 Universitat Universitat NNP cord-015021-pol2qm74 3415 9 Erlangen Erlangen NNP cord-015021-pol2qm74 3415 10 - - HYPH cord-015021-pol2qm74 3415 11 NQmberg NQmberg NNP cord-015021-pol2qm74 3415 12 , , , cord-015021-pol2qm74 3415 13 Krankenhausstral Krankenhausstral NNP cord-015021-pol2qm74 3415 14 ~ ~ NFP cord-015021-pol2qm74 3415 15 e e SYM cord-015021-pol2qm74 3415 16 12 12 CD cord-015021-pol2qm74 3415 17 , , , cord-015021-pol2qm74 3415 18 D-91054 D-91054 NNP cord-015021-pol2qm74 3415 19 Erlangen Erlangen NNP cord-015021-pol2qm74 3415 20 . . . cord-015021-pol2qm74 3416 1 In in IN cord-015021-pol2qm74 3416 2 this this DT cord-015021-pol2qm74 3416 3 study study NN cord-015021-pol2qm74 3416 4 we -PRON- PRP cord-015021-pol2qm74 3416 5 investigated investigate VBD cord-015021-pol2qm74 3416 6 the the DT cord-015021-pol2qm74 3416 7 involvement involvement NN cord-015021-pol2qm74 3416 8 of of IN cord-015021-pol2qm74 3416 9 serine serine JJ cord-015021-pol2qm74 3416 10 protease protease NN cord-015021-pol2qm74 3416 11 and and CC cord-015021-pol2qm74 3416 12 free free JJ cord-015021-pol2qm74 3416 13 radical radical JJ cord-015021-pol2qm74 3416 14 generation generation NN cord-015021-pol2qm74 3416 15 in in IN cord-015021-pol2qm74 3416 16 the the DT cord-015021-pol2qm74 3416 17 systemic systemic JJ cord-015021-pol2qm74 3416 18 release release NN cord-015021-pol2qm74 3416 19 of of IN cord-015021-pol2qm74 3416 20 tumor tumor NN cord-015021-pol2qm74 3416 21 necrosis necrosis NN cord-015021-pol2qm74 3416 22 factor factor NN cord-015021-pol2qm74 3416 23 - - HYPH cord-015021-pol2qm74 3416 24 alpha alpha NN cord-015021-pol2qm74 3416 25 ( ( -LRB- cord-015021-pol2qm74 3416 26 TNF TNF NNP cord-015021-pol2qm74 3416 27 ) ) -RRB- cord-015021-pol2qm74 3416 28 and and CC cord-015021-pol2qm74 3416 29 interieukin interieukin NNP cord-015021-pol2qm74 3416 30 I(IL-1 I(IL-1 NNP cord-015021-pol2qm74 3416 31 ) ) -RRB- cord-015021-pol2qm74 3416 32 , , , cord-015021-pol2qm74 3416 33 in in IN cord-015021-pol2qm74 3416 34 the the DT cord-015021-pol2qm74 3416 35 sepsis sepsis NN cord-015021-pol2qm74 3416 36 model model NN cord-015021-pol2qm74 3416 37 of of IN cord-015021-pol2qm74 3416 38 lipopolysaccharide lipopolysaccharide NN cord-015021-pol2qm74 3416 39 ( ( -LRB- cord-015021-pol2qm74 3416 40 LPS LPS NNP cord-015021-pol2qm74 3416 41 , , , cord-015021-pol2qm74 3416 42 5mg 5mg NN cord-015021-pol2qm74 3416 43 / / SYM cord-015021-pol2qm74 3416 44 kg kg NNP cord-015021-pol2qm74 3416 45 i.p i.p NNP cord-015021-pol2qm74 3416 46 . . . cord-015021-pol2qm74 3416 47 ) ) -RRB- cord-015021-pol2qm74 3416 48 induced induce VBN cord-015021-pol2qm74 3416 49 hepatitis hepatitis NN cord-015021-pol2qm74 3416 50 in in IN cord-015021-pol2qm74 3416 51 galactosamine galactosamine NNP cord-015021-pol2qm74 3416 52 ( ( -LRB- cord-015021-pol2qm74 3416 53 GAIN GAIN NNP cord-015021-pol2qm74 3416 54 , , , cord-015021-pol2qm74 3416 55 18rag 18rag JJ cord-015021-pol2qm74 3416 56 / / SYM cord-015021-pol2qm74 3416 57 mouse mouse NN cord-015021-pol2qm74 3416 58 , , , cord-015021-pol2qm74 3416 59 i.p i.p NNP cord-015021-pol2qm74 3416 60 . . NNP cord-015021-pol2qm74 3416 61 ) ) -RRB- cord-015021-pol2qm74 3417 1 sensitized sensitized JJ cord-015021-pol2qm74 3417 2 mice mouse NNS cord-015021-pol2qm74 3417 3 . . . cord-015021-pol2qm74 3418 1 Treatment treatment NN cord-015021-pol2qm74 3418 2 of of IN cord-015021-pol2qm74 3418 3 GAIN gain NN cord-015021-pol2qm74 3418 4 - - HYPH cord-015021-pol2qm74 3418 5 sensitized sensitize VBN cord-015021-pol2qm74 3418 6 mice mouse NNS cord-015021-pol2qm74 3418 7 with with IN cord-015021-pol2qm74 3418 8 LPS lp NNS cord-015021-pol2qm74 3418 9 ( ( -LRB- cord-015021-pol2qm74 3418 10 GAIN gain NN cord-015021-pol2qm74 3418 11 / / SYM cord-015021-pol2qm74 3418 12 LPS LPS NNP cord-015021-pol2qm74 3418 13 ) ) -RRB- cord-015021-pol2qm74 3418 14 led lead VBD cord-015021-pol2qm74 3418 15 to to IN cord-015021-pol2qm74 3418 16 dramatic dramatic JJ cord-015021-pol2qm74 3418 17 increase increase NN cord-015021-pol2qm74 3418 18 in in IN cord-015021-pol2qm74 3418 19 serum serum NN cord-015021-pol2qm74 3418 20 cytokine cytokine NN cord-015021-pol2qm74 3418 21 ( ( -LRB- cord-015021-pol2qm74 3418 22 TNF TNF NNP cord-015021-pol2qm74 3418 23 and and CC cord-015021-pol2qm74 3418 24 IL IL NNP cord-015021-pol2qm74 3418 25 - - : cord-015021-pol2qm74 3418 26 I I NNP cord-015021-pol2qm74 3418 27 ) ) -RRB- cord-015021-pol2qm74 3418 28 ievels ievel VBZ cord-015021-pol2qm74 3418 29 and and CC cord-015021-pol2qm74 3418 30 transaminase transaminase NN cord-015021-pol2qm74 3418 31 activity activity NN cord-015021-pol2qm74 3418 32 at at IN cord-015021-pol2qm74 3418 33 3 3 CD cord-015021-pol2qm74 3418 34 hr hr NN cord-015021-pol2qm74 3418 35 and and CC cord-015021-pol2qm74 3418 36 8 8 CD cord-015021-pol2qm74 3418 37 hr hr NN cord-015021-pol2qm74 3418 38 respectively respectively RB cord-015021-pol2qm74 3418 39 . . . cord-015021-pol2qm74 3419 1 Pretreatment pretreatment NN cord-015021-pol2qm74 3419 2 of of IN cord-015021-pol2qm74 3419 3 serine serine JJ cord-015021-pol2qm74 3419 4 protease protease NN cord-015021-pol2qm74 3419 5 inhibitor inhibitor NN cord-015021-pol2qm74 3419 6 , , , cord-015021-pol2qm74 3419 7 c c NNP cord-015021-pol2qm74 3419 8 ~ ~ NFP cord-015021-pol2qm74 3419 9 jantitrypsin jantitrypsin NNP cord-015021-pol2qm74 3419 10 ( ( -LRB- cord-015021-pol2qm74 3419 11 a a DT cord-015021-pol2qm74 3419 12 j j NNP cord-015021-pol2qm74 3419 13 - - HYPH cord-015021-pol2qm74 3419 14 AT AT NNP cord-015021-pol2qm74 3419 15 , , , cord-015021-pol2qm74 3419 16 50mg 50mg NN cord-015021-pol2qm74 3419 17 / / SYM cord-015021-pol2qm74 3419 18 kg kg NNP cord-015021-pol2qm74 3419 19 i.p i.p NNP cord-015021-pol2qm74 3419 20 . . NNP cord-015021-pol2qm74 3419 21 ) ) -RRB- cord-015021-pol2qm74 3419 22 , , , cord-015021-pol2qm74 3419 23 30 30 CD cord-015021-pol2qm74 3419 24 rains rain NNS cord-015021-pol2qm74 3419 25 prior prior RB cord-015021-pol2qm74 3419 26 to to IN cord-015021-pol2qm74 3419 27 GAIN gain VB cord-015021-pol2qm74 3419 28 / / SYM cord-015021-pol2qm74 3419 29 LPS lps NN cord-015021-pol2qm74 3419 30 treatment treatment NN cord-015021-pol2qm74 3419 31 , , , cord-015021-pol2qm74 3419 32 fully fully RB cord-015021-pol2qm74 3419 33 protected protect VBD cord-015021-pol2qm74 3419 34 the the DT cord-015021-pol2qm74 3419 35 animals animal NNS cord-015021-pol2qm74 3419 36 against against IN cord-015021-pol2qm74 3419 37 the the DT cord-015021-pol2qm74 3419 38 hepatotoxic hepatotoxic JJ cord-015021-pol2qm74 3419 39 challenge challenge NN cord-015021-pol2qm74 3419 40 with with IN cord-015021-pol2qm74 3419 41 significantly significantly RB cord-015021-pol2qm74 3419 42 reduced reduce VBN cord-015021-pol2qm74 3419 43 serum serum NN cord-015021-pol2qm74 3419 44 TNF TNF NNP cord-015021-pol2qm74 3419 45 and and CC cord-015021-pol2qm74 3419 46 IL-1 IL-1 NNP cord-015021-pol2qm74 3419 47 levels level NNS cord-015021-pol2qm74 3419 48 . . . cord-015021-pol2qm74 3420 1 In in IN cord-015021-pol2qm74 3420 2 order order NN cord-015021-pol2qm74 3420 3 to to TO cord-015021-pol2qm74 3420 4 block block VB cord-015021-pol2qm74 3420 5 and and CC cord-015021-pol2qm74 3420 6 scavenge scavenge VB cord-015021-pol2qm74 3420 7 superoxide superoxide NN cord-015021-pol2qm74 3420 8 generation generation NN cord-015021-pol2qm74 3420 9 , , , cord-015021-pol2qm74 3420 10 the the DT cord-015021-pol2qm74 3420 11 mice mouse NNS cord-015021-pol2qm74 3420 12 were be VBD cord-015021-pol2qm74 3420 13 pretreated pretreate VBN cord-015021-pol2qm74 3420 14 with with IN cord-015021-pol2qm74 3420 15 xanthine xanthine NN cord-015021-pol2qm74 3420 16 oxidase oxidase NN cord-015021-pol2qm74 3420 17 inhibitor inhibitor NN cord-015021-pol2qm74 3420 18 , , , cord-015021-pol2qm74 3420 19 allopurinol allopurinol NNP cord-015021-pol2qm74 3420 20 ( ( -LRB- cord-015021-pol2qm74 3420 21 AL AL NNP cord-015021-pol2qm74 3420 22 , , , cord-015021-pol2qm74 3420 23 2 2 CD cord-015021-pol2qm74 3420 24 x x SYM cord-015021-pol2qm74 3420 25 100mg 100mg NNP cord-015021-pol2qm74 3420 26 / / SYM cord-015021-pol2qm74 3420 27 kg kg NNP cord-015021-pol2qm74 3420 28 i.p i.p NNP cord-015021-pol2qm74 3420 29 . . NNP cord-015021-pol2qm74 3420 30 ) ) -RRB- cord-015021-pol2qm74 3420 31 and and CC cord-015021-pol2qm74 3420 32 pyran pyran JJ cord-015021-pol2qm74 3420 33 polymer polymer NN cord-015021-pol2qm74 3420 34 - - HYPH cord-015021-pol2qm74 3420 35 conjugated conjugate VBN cord-015021-pol2qm74 3420 36 superoxide superoxide NN cord-015021-pol2qm74 3420 37 dismutase dismutase NN cord-015021-pol2qm74 3420 38 ( ( -LRB- cord-015021-pol2qm74 3420 39 SOD SOD NNP cord-015021-pol2qm74 3420 40 , , , cord-015021-pol2qm74 3420 41 2 2 CD cord-015021-pol2qm74 3420 42 x x SYM cord-015021-pol2qm74 3420 43 200 200 CD cord-015021-pol2qm74 3420 44 unit unit NN cord-015021-pol2qm74 3420 45 / / SYM cord-015021-pol2qm74 3420 46 mouse mouse NN cord-015021-pol2qm74 3420 47 i.v i.v NNP cord-015021-pol2qm74 3420 48 ) ) -RRB- cord-015021-pol2qm74 3421 1 r6spectively r6spectively RB cord-015021-pol2qm74 3421 2 . . . cord-015021-pol2qm74 3422 1 Pretreatment pretreatment NN cord-015021-pol2qm74 3422 2 with with IN cord-015021-pol2qm74 3422 3 AL AL NNP cord-015021-pol2qm74 3422 4 and and CC cord-015021-pol2qm74 3422 5 SOD SOD NNP cord-015021-pol2qm74 3422 6 ( ( -LRB- cord-015021-pol2qm74 3422 7 24 24 CD cord-015021-pol2qm74 3422 8 and and CC cord-015021-pol2qm74 3422 9 1 1 CD cord-015021-pol2qm74 3422 10 hr hr NN cord-015021-pol2qm74 3422 11 prior prior RB cord-015021-pol2qm74 3422 12 to to IN cord-015021-pol2qm74 3422 13 GAIN gain VB cord-015021-pol2qm74 3422 14 / / SYM cord-015021-pol2qm74 3422 15 LPS LPS NNP cord-015021-pol2qm74 3422 16 ) ) -RRB- cord-015021-pol2qm74 3422 17 prevented prevent VBD cord-015021-pol2qm74 3422 18 GAIN gain NN cord-015021-pol2qm74 3422 19 / / SYM cord-015021-pol2qm74 3422 20 LPS lp NNS cord-015021-pol2qm74 3422 21 hepatitis hepatitis NN cord-015021-pol2qm74 3422 22 and and CC cord-015021-pol2qm74 3422 23 blocked block VBD cord-015021-pol2qm74 3422 24 LPS LPS NNP cord-015021-pol2qm74 3422 25 induced induce VBN cord-015021-pol2qm74 3422 26 released release VBN cord-015021-pol2qm74 3422 27 of of IN cord-015021-pol2qm74 3422 28 TNF TNF NNP cord-015021-pol2qm74 3422 29 and and CC cord-015021-pol2qm74 3422 30 IL-1 IL-1 NNP cord-015021-pol2qm74 3422 31 into into IN cord-015021-pol2qm74 3422 32 serum serum NN cord-015021-pol2qm74 3422 33 of of IN cord-015021-pol2qm74 3422 34 the the DT cord-015021-pol2qm74 3422 35 mice mouse NNS cord-015021-pol2qm74 3422 36 . . . cord-015021-pol2qm74 3423 1 The the DT cord-015021-pol2qm74 3423 2 protective protective JJ cord-015021-pol2qm74 3423 3 agents agent NNS cord-015021-pol2qm74 3423 4 like like IN cord-015021-pol2qm74 3423 5 cq cq NNP cord-015021-pol2qm74 3423 6 - - HYPH cord-015021-pol2qm74 3423 7 AT AT NNP cord-015021-pol2qm74 3423 8 or or CC cord-015021-pol2qm74 3423 9 AL AL NNP cord-015021-pol2qm74 3423 10 / / SYM cord-015021-pol2qm74 3423 11 SOD SOD NNP cord-015021-pol2qm74 3423 12 did do VBD cord-015021-pol2qm74 3423 13 not not RB cord-015021-pol2qm74 3423 14 protect protect VB cord-015021-pol2qm74 3423 15 the the DT cord-015021-pol2qm74 3423 16 mice mice NN cord-015021-pol2qm74 3423 17 against against IN cord-015021-pol2qm74 3423 18 th~ th~ NNP cord-015021-pol2qm74 3424 1 hPp hPp NNP cord-015021-pol2qm74 3424 2 ~ ~ NFP cord-015021-pol2qm74 3424 3 totoxi£ totoxi£ NNP cord-015021-pol2qm74 3424 4 ch~ ch~ NN cord-015021-pol2qm74 3425 1 llPn llpn LS cord-015021-pol2qm74 3425 2 - - HYPH cord-015021-pol2qm74 3425 3 e e LS cord-015021-pol2qm74 3425 4 indllee4 indllee4 NN cord-015021-pol2qm74 3425 5 b'~ b'~ NNS cord-015021-pol2qm74 3426 1 th~ th~ NNP cord-015021-pol2qm74 3426 2 recombinant recombinant JJ cord-015021-pol2qm74 3426 3 mmlse mmlse NNP cord-015021-pol2qm74 3426 4 TNF TNF NNP cord-015021-pol2qm74 3426 5 - - HYPH cord-015021-pol2qm74 3426 6 o o NNP cord-015021-pol2qm74 3426 7 ' ' '' cord-015021-pol2qm74 3426 8 ( ( -LRB- cord-015021-pol2qm74 3426 9 0.3 0.3 CD cord-015021-pol2qm74 3426 10 ~/rno ~/rno NNS cord-015021-pol2qm74 3426 11 ~ ~ NFP cord-015021-pol2qm74 3426 12 e e NNP cord-015021-pol2qm74 3426 13 J.p J.p NNP cord-015021-pol2qm74 3426 14 . . . cord-015021-pol2qm74 3426 15 ) ) -RRB- cord-015021-pol2qm74 3427 1 ~d ~d NNP cord-015021-pol2qm74 3427 2 oI oi UH cord-015021-pol2qm74 3427 3 ~ ~ NFP cord-015021-pol2qm74 3427 4 LPS LPS NNP cord-015021-pol2qm74 3427 5 1~ 1~ CD cord-015021-pol2qm74 3427 6 CAlN-.~dlfa%aed CAlN-.~dlfa%aed NNP cord-015021-pol2qm74 3427 7 mlce mlce NNP cord-015021-pol2qm74 3427 8 . . . cord-015021-pol2qm74 3428 1 It -PRON- PRP cord-015021-pol2qm74 3428 2 - - HYPH cord-015021-pol2qm74 3428 3 l l NN cord-015021-pol2qm74 3428 4 cett cett NNP cord-015021-pol2qm74 3428 5 ~ ~ NFP cord-015021-pol2qm74 3428 6 aged age VBN cord-015021-pol2qm74 3428 7 la la NNP cord-015021-pol2qm74 3428 8 TNF TNF NNP cord-015021-pol2qm74 3429 1 ( ( -LRB- cord-015021-pol2qm74 3429 2 x x NN cord-015021-pol2qm74 3429 3 / / SYM cord-015021-pol2qm74 3429 4 GAIN gain VB cord-015021-pol2qm74 3429 5 treated treat VBN cord-015021-pol2qm74 3429 6 mJde mJde NNP cord-015021-pol2qm74 3429 7 was be VBD cord-015021-pol2qm74 3429 8 not not RB cord-015021-pol2qm74 3429 9 detectable detectable JJ cord-015021-pol2qm74 3429 10 in in IN cord-015021-pol2qm74 3429 11 animals animal NNS cord-015021-pol2qm74 3429 12 pretreated pretreate VBN cord-015021-pol2qm74 3429 13 with with IN cord-015021-pol2qm74 3429 14 oq oq NN cord-015021-pol2qm74 3429 15 - - HYPH cord-015021-pol2qm74 3429 16 AT at NN cord-015021-pol2qm74 3429 17 or or CC cord-015021-pol2qm74 3429 18 AL AL NNP cord-015021-pol2qm74 3429 19 / / SYM cord-015021-pol2qm74 3429 20 SOD SOD NNP cord-015021-pol2qm74 3429 21 . . . cord-015021-pol2qm74 3430 1 Our -PRON- PRP$ cord-015021-pol2qm74 3430 2 study study NN cord-015021-pol2qm74 3430 3 suggests suggest VBZ cord-015021-pol2qm74 3430 4 that that IN cord-015021-pol2qm74 3430 5 a a DT cord-015021-pol2qm74 3430 6 serine serine NN cord-015021-pol2qm74 3430 7 protease protease NN cord-015021-pol2qm74 3430 8 sensitive sensitive JJ cord-015021-pol2qm74 3430 9 to to IN cord-015021-pol2qm74 3430 10 cq cq NN cord-015021-pol2qm74 3430 11 - - HYPH cord-015021-pol2qm74 3430 12 antitrypsin antitrypsin NN cord-015021-pol2qm74 3430 13 is be VBZ cord-015021-pol2qm74 3430 14 responsible responsible JJ cord-015021-pol2qm74 3430 15 in in IN cord-015021-pol2qm74 3430 16 regulating regulate VBG cord-015021-pol2qm74 3430 17 TNF TNF NNP cord-015021-pol2qm74 3430 18 release release NN cord-015021-pol2qm74 3430 19 , , , cord-015021-pol2qm74 3430 20 possibly possibly RB cord-015021-pol2qm74 3430 21 by by IN cord-015021-pol2qm74 3430 22 proteolytic proteolytic JJ cord-015021-pol2qm74 3430 23 cleavage cleavage NN cord-015021-pol2qm74 3430 24 of of IN cord-015021-pol2qm74 3430 25 a a DT cord-015021-pol2qm74 3430 26 TNF tnf NN cord-015021-pol2qm74 3430 27 - - HYPH cord-015021-pol2qm74 3430 28 precursor precursor NN cord-015021-pol2qm74 3430 29 or or CC cord-015021-pol2qm74 3430 30 membrane membrane NN cord-015021-pol2qm74 3430 31 bound bind VBN cord-015021-pol2qm74 3430 32 TNF TNF NNP cord-015021-pol2qm74 3430 33 . . . cord-015021-pol2qm74 3431 1 In in IN cord-015021-pol2qm74 3431 2 addition addition NN cord-015021-pol2qm74 3431 3 our -PRON- PRP$ cord-015021-pol2qm74 3431 4 evidence evidence NN cord-015021-pol2qm74 3431 5 suggest suggest VBP cord-015021-pol2qm74 3431 6 that that IN cord-015021-pol2qm74 3431 7 the the DT cord-015021-pol2qm74 3431 8 balance balance NN cord-015021-pol2qm74 3431 9 of of IN cord-015021-pol2qm74 3431 10 extracellular extracellular JJ cord-015021-pol2qm74 3431 11 protease protease NN cord-015021-pol2qm74 3431 12 / / SYM cord-015021-pol2qm74 3431 13 antiprotease antiprotease NN cord-015021-pol2qm74 3431 14 activity activity NN cord-015021-pol2qm74 3431 15 may may MD cord-015021-pol2qm74 3431 16 be be VB cord-015021-pol2qm74 3431 17 regulated regulate VBN cord-015021-pol2qm74 3431 18 by by IN cord-015021-pol2qm74 3431 19 free free JJ cord-015021-pol2qm74 3431 20 radical radical JJ cord-015021-pol2qm74 3431 21 generation generation NN cord-015021-pol2qm74 3431 22 , , , cord-015021-pol2qm74 3431 23 possible possible JJ cord-015021-pol2qm74 3431 24 superoxide superoxide NN cord-015021-pol2qm74 3431 25 anion anion NN cord-015021-pol2qm74 3431 26 , , , cord-015021-pol2qm74 3431 27 resulting result VBG cord-015021-pol2qm74 3431 28 in in IN cord-015021-pol2qm74 3431 29 inactivation inactivation NN cord-015021-pol2qm74 3431 30 of of IN cord-015021-pol2qm74 3431 31 the the DT cord-015021-pol2qm74 3431 32 antiprotease antiprotease NN cord-015021-pol2qm74 3431 33 . . . cord-015021-pol2qm74 3432 1 IL-1 IL-1 NNP cord-015021-pol2qm74 3433 1 release release NN cord-015021-pol2qm74 3433 2 may may MD cord-015021-pol2qm74 3433 3 be be VB cord-015021-pol2qm74 3433 4 subsequent subsequent JJ cord-015021-pol2qm74 3433 5 to to IN cord-015021-pol2qm74 3433 6 TNF TNF NNP cord-015021-pol2qm74 3433 7 release release NN cord-015021-pol2qm74 3433 8 . . . cord-015021-pol2qm74 3434 1 Objective objective JJ cord-015021-pol2qm74 3434 2 : : : cord-015021-pol2qm74 3434 3 During during IN cord-015021-pol2qm74 3434 4 sepsis sepsis NN cord-015021-pol2qm74 3434 5 one one PRP cord-015021-pol2qm74 3434 6 can can MD cord-015021-pol2qm74 3434 7 observe observe VB cord-015021-pol2qm74 3434 8 a a DT cord-015021-pol2qm74 3434 9 dramatically dramatically RB cord-015021-pol2qm74 3434 10 impaired impair VBN cord-015021-pol2qm74 3434 11 production production NN cord-015021-pol2qm74 3434 12 of of IN cord-015021-pol2qm74 3434 13 proinflammatory proinflammatory JJ cord-015021-pol2qm74 3434 14 cytokines cytokine NNS cord-015021-pol2qm74 3434 15 like like IN cord-015021-pol2qm74 3434 16 the the DT cord-015021-pol2qm74 3434 17 Tumor tumor NN cord-015021-pol2qm74 3434 18 necrosis necrosis NN cord-015021-pol2qm74 3434 19 factor factor NN cord-015021-pol2qm74 3434 20 alpha alpha NN cord-015021-pol2qm74 3434 21 ( ( -LRB- cord-015021-pol2qm74 3434 22 TNF TNF NNP cord-015021-pol2qm74 3434 23 - - HYPH cord-015021-pol2qm74 3434 24 a a NNP cord-015021-pol2qm74 3434 25 ) ) -RRB- cord-015021-pol2qm74 3434 26 , , , cord-015021-pol2qm74 3434 27 Interleukin Interleukin NNP cord-015021-pol2qm74 3434 28 I i NN cord-015021-pol2qm74 3434 29 - - HYPH cord-015021-pol2qm74 3434 30 alpha alpha NN cord-015021-pol2qm74 3435 1 ( ( -LRB- cord-015021-pol2qm74 3435 2 IL IL NNP cord-015021-pol2qm74 3435 3 - - HYPH cord-015021-pol2qm74 3435 4 la la NNP cord-015021-pol2qm74 3435 5 ) ) -RRB- cord-015021-pol2qm74 3436 1 , , , cord-015021-pol2qm74 3436 2 Intedeukin Intedeukin NNP cord-015021-pol2qm74 3436 3 I i NN cord-015021-pol2qm74 3436 4 - - HYPH cord-015021-pol2qm74 3436 5 beta beta NN cord-015021-pol2qm74 3437 1 ( ( -LRB- cord-015021-pol2qm74 3437 2 IL IL NNP cord-015021-pol2qm74 3437 3 - - HYPH cord-015021-pol2qm74 3437 4 I I NNP cord-015021-pol2qm74 3437 5 & & CC cord-015021-pol2qm74 3437 6 ) ) -RRB- cord-015021-pol2qm74 3437 7 and and CC cord-015021-pol2qm74 3437 8 Interferon Interferon NNP cord-015021-pol2qm74 3437 9 gamma gamma NN cord-015021-pol2qm74 3437 10 ( ( -LRB- cord-015021-pol2qm74 3437 11 IF~ IF~ NNP cord-015021-pol2qm74 3437 12 ) ) -RRB- cord-015021-pol2qm74 3437 13 upon upon IN cord-015021-pol2qm74 3437 14 in in IN cord-015021-pol2qm74 3437 15 vitro vitro FW cord-015021-pol2qm74 3437 16 stimulation stimulation NN cord-015021-pol2qm74 3437 17 of of IN cord-015021-pol2qm74 3437 18 circulating circulate VBG cord-015021-pol2qm74 3437 19 cells cell NNS cord-015021-pol2qm74 3437 20 . . . cord-015021-pol2qm74 3438 1 However however RB cord-015021-pol2qm74 3438 2 there there EX cord-015021-pol2qm74 3438 3 is be VBZ cord-015021-pol2qm74 3438 4 also also RB cord-015021-pol2qm74 3438 5 evidence evidence NN cord-015021-pol2qm74 3438 6 of of IN cord-015021-pol2qm74 3438 7 a a DT cord-015021-pol2qm74 3438 8 decreased decrease VBN cord-015021-pol2qm74 3438 9 ability ability NN cord-015021-pol2qm74 3438 10 to to TO cord-015021-pol2qm74 3438 11 produce produce VB cord-015021-pol2qm74 3438 12 cytokines cytokine NNS cord-015021-pol2qm74 3438 13 in in IN cord-015021-pol2qm74 3438 14 other other JJ cord-015021-pol2qm74 3438 15 immuno immuno JJ cord-015021-pol2qm74 3438 16 - - HYPH cord-015021-pol2qm74 3438 17 deficient deficient JJ cord-015021-pol2qm74 3438 18 states state NNS cord-015021-pol2qm74 3438 19 . . . cord-015021-pol2qm74 3439 1 In in IN cord-015021-pol2qm74 3439 2 this this DT cord-015021-pol2qm74 3439 3 study study NN cord-015021-pol2qm74 3439 4 we -PRON- PRP cord-015021-pol2qm74 3439 5 compared compare VBD cord-015021-pol2qm74 3439 6 the the DT cord-015021-pol2qm74 3439 7 capacity capacity NN cord-015021-pol2qm74 3439 8 to to TO cord-015021-pol2qm74 3439 9 secrete secrete VB cord-015021-pol2qm74 3439 10 proinflammatory proinflammatory JJ cord-015021-pol2qm74 3439 11 cytokines cytokine NNS cord-015021-pol2qm74 3439 12 upon upon IN cord-015021-pol2qm74 3439 13 in in IN cord-015021-pol2qm74 3439 14 vitro vitro FW cord-015021-pol2qm74 3439 15 stimulation stimulation NN cord-015021-pol2qm74 3439 16 of of IN cord-015021-pol2qm74 3439 17 patients patient NNS cord-015021-pol2qm74 3439 18 in in IN cord-015021-pol2qm74 3439 19 severe severe JJ cord-015021-pol2qm74 3439 20 sepsis sepsis NN cord-015021-pol2qm74 3439 21 and and CC cord-015021-pol2qm74 3439 22 patients patient NNS cord-015021-pol2qm74 3439 23 with with IN cord-015021-pol2qm74 3439 24 malignant malignant JJ cord-015021-pol2qm74 3439 25 tumors tumor NNS cord-015021-pol2qm74 3439 26 . . . cord-015021-pol2qm74 3440 1 Methods method NNS cord-015021-pol2qm74 3440 2 : : : cord-015021-pol2qm74 3441 1 Heparinized heparinize VBN cord-015021-pol2qm74 3441 2 blood blood NN cord-015021-pol2qm74 3441 3 samples sample NNS cord-015021-pol2qm74 3441 4 of of IN cord-015021-pol2qm74 3441 5 ten ten CD cord-015021-pol2qm74 3441 6 patients patient NNS cord-015021-pol2qm74 3441 7 ( ( -LRB- cord-015021-pol2qm74 3441 8 62 62 CD cord-015021-pol2qm74 3441 9 + + SYM cord-015021-pol2qm74 3441 10 14 14 CD cord-015021-pol2qm74 3441 11 years year NNS cord-015021-pol2qm74 3441 12 ) ) -RRB- cord-015021-pol2qm74 3441 13 in in IN cord-015021-pol2qm74 3441 14 severe severe JJ cord-015021-pol2qm74 3441 15 sepsis sepsis NN cord-015021-pol2qm74 3442 1 ( ( -LRB- cord-015021-pol2qm74 3442 2 sepsis sepsis NN cord-015021-pol2qm74 3442 3 score score NN cord-015021-pol2qm74 3442 4 > > XX cord-015021-pol2qm74 3443 1 15 15 CD cord-015021-pol2qm74 3444 1 according accord VBG cord-015021-pol2qm74 3444 2 to to IN cord-015021-pol2qm74 3444 3 E}ebute e}ebute CD cord-015021-pol2qm74 3444 4 and and CC cord-015021-pol2qm74 3444 5 Stoner Stoner NNP cord-015021-pol2qm74 3444 6 ) ) -RRB- cord-015021-pol2qm74 3444 7 were be VBD cord-015021-pol2qm74 3444 8 drawn draw VBN cord-015021-pol2qm74 3444 9 at at IN cord-015021-pol2qm74 3444 10 onset onset NN cord-015021-pol2qm74 3444 11 of of IN cord-015021-pol2qm74 3444 12 disease disease NN cord-015021-pol2qm74 3444 13 , , , cord-015021-pol2qm74 3444 14 From from IN cord-015021-pol2qm74 3444 15 fifteen fifteen CD cord-015021-pol2qm74 3444 16 patients patient NNS cord-015021-pol2qm74 3444 17 with with IN cord-015021-pol2qm74 3444 18 solid solid JJ cord-015021-pol2qm74 3444 19 growing grow VBG cord-015021-pol2qm74 3444 20 carcinoma carcinoma NN cord-015021-pol2qm74 3444 21 ( ( -LRB- cord-015021-pol2qm74 3444 22 59 59 CD cord-015021-pol2qm74 3444 23 + + SYM cord-015021-pol2qm74 3444 24 19 19 CD cord-015021-pol2qm74 3444 25 years year NNS cord-015021-pol2qm74 3444 26 ) ) -RRB- cord-015021-pol2qm74 3444 27 blood blood NN cord-015021-pol2qm74 3444 28 was be VBD cord-015021-pol2qm74 3444 29 drawn draw VBN cord-015021-pol2qm74 3444 30 at at IN cord-015021-pol2qm74 3444 31 diagnosis diagnosis NN cord-015021-pol2qm74 3444 32 prior prior RB cord-015021-pol2qm74 3444 33 to to IN cord-015021-pol2qm74 3444 34 any any DT cord-015021-pol2qm74 3444 35 therapy therapy NN cord-015021-pol2qm74 3444 36 . . . cord-015021-pol2qm74 3445 1 Controls control NNS cord-015021-pol2qm74 3445 2 were be VBD cord-015021-pol2qm74 3445 3 obtained obtain VBN cord-015021-pol2qm74 3445 4 from from IN cord-015021-pol2qm74 3445 5 fifteen fifteen CD cord-015021-pol2qm74 3445 6 healthy healthy JJ cord-015021-pol2qm74 3445 7 volunteers volunteer NNS cord-015021-pol2qm74 3445 8 . . . cord-015021-pol2qm74 3446 1 50 50 CD cord-015021-pol2qm74 3446 2 pl pl NNS cord-015021-pol2qm74 3446 3 of of IN cord-015021-pol2qm74 3446 4 whole whole JJ cord-015021-pol2qm74 3446 5 blood blood NN cord-015021-pol2qm74 3446 6 were be VBD cord-015021-pol2qm74 3446 7 incubated incubate VBN cord-015021-pol2qm74 3446 8 either either CC cord-015021-pol2qm74 3446 9 with with IN cord-015021-pol2qm74 3446 10 450/4 450/4 CD cord-015021-pol2qm74 3446 11 of of IN cord-015021-pol2qm74 3446 12 a a DT cord-015021-pol2qm74 3446 13 standard standard JJ cord-015021-pol2qm74 3446 14 medium medium NN cord-015021-pol2qm74 3446 15 or or CC cord-015021-pol2qm74 3446 16 with with IN cord-015021-pol2qm74 3446 17 400 400 CD cord-015021-pol2qm74 3446 18 pl pl NNS cord-015021-pol2qm74 3446 19 of of IN cord-015021-pol2qm74 3446 20 a a DT cord-015021-pol2qm74 3446 21 standard standard JJ cord-015021-pol2qm74 3446 22 medium medium NN cord-015021-pol2qm74 3446 23 and and CC cord-015021-pol2qm74 3446 24 50 50 CD cord-015021-pol2qm74 3446 25 pl pl NNS cord-015021-pol2qm74 3446 26 of of IN cord-015021-pol2qm74 3446 27 phytohemagglutinin phytohemagglutinin NN cord-015021-pol2qm74 3446 28 ( ( -LRB- cord-015021-pol2qm74 3446 29 PHA PHA NNP cord-015021-pol2qm74 3446 30 ) ) -RRB- cord-015021-pol2qm74 3446 31 a a DT cord-015021-pol2qm74 3446 32 potent potent JJ cord-015021-pol2qm74 3446 33 mitogen mitogen NN cord-015021-pol2qm74 3446 34 . . . cord-015021-pol2qm74 3447 1 After after IN cord-015021-pol2qm74 3447 2 an an DT cord-015021-pol2qm74 3447 3 incubation incubation NN cord-015021-pol2qm74 3447 4 period period NN cord-015021-pol2qm74 3447 5 of of IN cord-015021-pol2qm74 3447 6 24 24 CD cord-015021-pol2qm74 3447 7 hours hour NNS cord-015021-pol2qm74 3447 8 plasma plasma NN cord-015021-pol2qm74 3447 9 concentrations concentration NNS cord-015021-pol2qm74 3447 10 of of IN cord-015021-pol2qm74 3447 11 TNF TNF NNP cord-015021-pol2qm74 3447 12 - - HYPH cord-015021-pol2qm74 3447 13 a a NNP cord-015021-pol2qm74 3447 14 , , , cord-015021-pol2qm74 3447 15 IL IL NNP cord-015021-pol2qm74 3447 16 - - HYPH cord-015021-pol2qm74 3447 17 la la NNP cord-015021-pol2qm74 3447 18 , , , cord-015021-pol2qm74 3447 19 IL-16 IL-16 NNP cord-015021-pol2qm74 3447 20 and and CC cord-015021-pol2qm74 3447 21 IF-~ IF-~ NNP cord-015021-pol2qm74 3447 22 were be VBD cord-015021-pol2qm74 3447 23 determined determine VBN cord-015021-pol2qm74 3447 24 by by IN cord-015021-pol2qm74 3447 25 ELISA ELISA NNP cord-015021-pol2qm74 3447 26 . . . cord-015021-pol2qm74 3448 1 Comments comment NNS cord-015021-pol2qm74 3448 2 : : : cord-015021-pol2qm74 3449 1 Our -PRON- PRP$ cord-015021-pol2qm74 3449 2 results result NNS cord-015021-pol2qm74 3449 3 suggest suggest VBP cord-015021-pol2qm74 3449 4 that that IN cord-015021-pol2qm74 3449 5 down down IN cord-015021-pol2qm74 3449 6 - - HYPH cord-015021-pol2qm74 3449 7 regulation regulation NN cord-015021-pol2qm74 3449 8 of of IN cord-015021-pol2qm74 3449 9 cytokine cytokine JJ cord-015021-pol2qm74 3449 10 secretion secretion NN cord-015021-pol2qm74 3449 11 or or CC cord-015021-pol2qm74 3449 12 of of IN cord-015021-pol2qm74 3449 13 cell cell NN cord-015021-pol2qm74 3449 14 responsiveness responsiveness NN cord-015021-pol2qm74 3449 15 to to IN cord-015021-pol2qm74 3449 16 non non JJ cord-015021-pol2qm74 3449 17 - - JJ cord-015021-pol2qm74 3449 18 specific specific JJ cord-015021-pol2qm74 3449 19 mitogens mitogen NNS cord-015021-pol2qm74 3449 20 during during IN cord-015021-pol2qm74 3449 21 sepsis sepsis NN cord-015021-pol2qm74 3449 22 has have VBZ cord-015021-pol2qm74 3449 23 occurred occur VBN cord-015021-pol2qm74 3449 24 . . . cord-015021-pol2qm74 3450 1 We -PRON- PRP cord-015021-pol2qm74 3450 2 observe observe VBP cord-015021-pol2qm74 3450 3 a a DT cord-015021-pol2qm74 3450 4 similar similar JJ cord-015021-pol2qm74 3450 5 phenomenon phenomenon NN cord-015021-pol2qm74 3450 6 for for IN cord-015021-pol2qm74 3450 7 the the DT cord-015021-pol2qm74 3450 8 group group NN cord-015021-pol2qm74 3450 9 of of IN cord-015021-pol2qm74 3450 10 carcinoma carcinoma JJ cord-015021-pol2qm74 3450 11 patients patient NNS cord-015021-pol2qm74 3450 12 vs vs IN cord-015021-pol2qm74 3450 13 control control NN cord-015021-pol2qm74 3450 14 significant significant JJ cord-015021-pol2qm74 3450 15 for for IN cord-015021-pol2qm74 3450 16 stimulated stimulate VBN cord-015021-pol2qm74 3450 17 TNF TNF NNP cord-015021-pol2qm74 3450 18 - - , cord-015021-pol2qm74 3450 19 a a NNP cord-015021-pol2qm74 3450 20 and and CC cord-015021-pol2qm74 3450 21 stimulated stimulate VBN cord-015021-pol2qm74 3451 1 IF if NN cord-015021-pol2qm74 3451 2 - - HYPH cord-015021-pol2qm74 3451 3 T. t. NN cord-015021-pol2qm74 3451 4 Sustained sustained JJ cord-015021-pol2qm74 3451 5 immunological immunological JJ cord-015021-pol2qm74 3451 6 interactions interaction NNS cord-015021-pol2qm74 3451 7 between between IN cord-015021-pol2qm74 3451 8 tumorcells tumorcell NNS cord-015021-pol2qm74 3451 9 and and CC cord-015021-pol2qm74 3451 10 cytokine cytokine NN cord-015021-pol2qm74 3451 11 producing produce VBG cord-015021-pol2qm74 3451 12 cells cell NNS cord-015021-pol2qm74 3451 13 could could MD cord-015021-pol2qm74 3451 14 effect effect VB cord-015021-pol2qm74 3451 15 responsiveness responsiveness NN cord-015021-pol2qm74 3451 16 of of IN cord-015021-pol2qm74 3451 17 the the DT cord-015021-pol2qm74 3451 18 latter latter JJ cord-015021-pol2qm74 3451 19 , , , cord-015021-pol2qm74 3451 20 A a DT cord-015021-pol2qm74 3451 21 general general JJ cord-015021-pol2qm74 3451 22 increased increase VBN cord-015021-pol2qm74 3451 23 immuno immuno JJ cord-015021-pol2qm74 3451 24 - - JJ cord-015021-pol2qm74 3451 25 tolerant tolerant JJ cord-015021-pol2qm74 3451 26 state state NN cord-015021-pol2qm74 3451 27 in in IN cord-015021-pol2qm74 3451 28 patients patient NNS cord-015021-pol2qm74 3451 29 with with IN cord-015021-pol2qm74 3451 30 carcinoma carcinoma NN cord-015021-pol2qm74 3451 31 has have VBZ cord-015021-pol2qm74 3451 32 to to TO cord-015021-pol2qm74 3451 33 be be VB cord-015021-pol2qm74 3451 34 discussed discuss VBN cord-015021-pol2qm74 3451 35 . . . cord-015021-pol2qm74 3452 1 However however RB cord-015021-pol2qm74 3452 2 we -PRON- PRP cord-015021-pol2qm74 3452 3 found find VBD cord-015021-pol2qm74 3452 4 significant significant JJ cord-015021-pol2qm74 3452 5 differences difference NNS cord-015021-pol2qm74 3452 6 between between IN cord-015021-pol2qm74 3452 7 sepsis sepsis NN cord-015021-pol2qm74 3452 8 and and CC cord-015021-pol2qm74 3452 9 cancer cancer NN cord-015021-pol2qm74 3452 10 concerning concern VBG cord-015021-pol2qm74 3452 11 the the DT cord-015021-pol2qm74 3452 12 in in FW cord-015021-pol2qm74 3452 13 vitro vitro FW cord-015021-pol2qm74 3452 14 capacity capacity NN cord-015021-pol2qm74 3452 15 of of IN cord-015021-pol2qm74 3452 16 responsable responsable JJ cord-015021-pol2qm74 3452 17 cells cell NNS cord-015021-pol2qm74 3452 18 to to TO cord-015021-pol2qm74 3452 19 produce produce VB cord-015021-pol2qm74 3452 20 IL IL NNP cord-015021-pol2qm74 3452 21 - - HYPH cord-015021-pol2qm74 3452 22 la la NNP cord-015021-pol2qm74 3452 23 and and CC cord-015021-pol2qm74 3452 24 IL IL NNP cord-015021-pol2qm74 3452 25 - - : cord-015021-pol2qm74 3452 26 I I NNP cord-015021-pol2qm74 3452 27 # # NN cord-015021-pol2qm74 3452 28 . . . cord-015021-pol2qm74 3453 1 The the DT cord-015021-pol2qm74 3453 2 dramatically dramatically RB cord-015021-pol2qm74 3453 3 decrease decrease NN cord-015021-pol2qm74 3453 4 of of IN cord-015021-pol2qm74 3453 5 the the DT cord-015021-pol2qm74 3453 6 ability ability NN cord-015021-pol2qm74 3453 7 to to TO cord-015021-pol2qm74 3453 8 produce produce VB cord-015021-pol2qm74 3453 9 IL IL NNP cord-015021-pol2qm74 3453 10 - - : cord-015021-pol2qm74 3453 11 I -PRON- PRP cord-015021-pol2qm74 3453 12 upon upon IN cord-015021-pol2qm74 3453 13 in in IN cord-015021-pol2qm74 3453 14 vitro vitro FW cord-015021-pol2qm74 3453 15 stimulation stimulation NN cord-015021-pol2qm74 3453 16 could could MD cord-015021-pol2qm74 3453 17 be be VB cord-015021-pol2qm74 3453 18 more more RBR cord-015021-pol2qm74 3453 19 sensitive sensitive JJ cord-015021-pol2qm74 3453 20 for for IN cord-015021-pol2qm74 3453 21 a a DT cord-015021-pol2qm74 3453 22 septic septic JJ cord-015021-pol2qm74 3453 23 state state NN cord-015021-pol2qm74 3453 24 than than IN cord-015021-pol2qm74 3453 25 stimulated stimulate VBN cord-015021-pol2qm74 3453 26 TNF TNF NNP cord-015021-pol2qm74 3453 27 - - : cord-015021-pol2qm74 3453 28 a a NN cord-015021-pol2qm74 3453 29 or or CC cord-015021-pol2qm74 3453 30 IF-3 IF-3 NNP cord-015021-pol2qm74 3453 31 , , , cord-015021-pol2qm74 3453 32 . . . cord-015021-pol2qm74 3454 1 Objective objective NN cord-015021-pol2qm74 3454 2 : : : cord-015021-pol2qm74 3455 1 Tumor tumor NN cord-015021-pol2qm74 3455 2 necrosis necrosis NN cord-015021-pol2qm74 3455 3 factor factor NN cord-015021-pol2qm74 3455 4 alpha alpha NN cord-015021-pol2qm74 3455 5 ( ( -LRB- cord-015021-pol2qm74 3455 6 TNF TNF NNP cord-015021-pol2qm74 3455 7 - - HYPH cord-015021-pol2qm74 3455 8 a a NN cord-015021-pol2qm74 3455 9 ) ) -RRB- cord-015021-pol2qm74 3455 10 has have VBZ cord-015021-pol2qm74 3455 11 been be VBN cord-015021-pol2qm74 3455 12 implicated implicate VBN cord-015021-pol2qm74 3455 13 as as IN cord-015021-pol2qm74 3455 14 a a DT cord-015021-pol2qm74 3455 15 central central JJ cord-015021-pol2qm74 3455 16 mediator mediator NN cord-015021-pol2qm74 3455 17 of of IN cord-015021-pol2qm74 3455 18 sepsis sepsis NN cord-015021-pol2qm74 3455 19 and and CC cord-015021-pol2qm74 3455 20 its -PRON- PRP$ cord-015021-pol2qm74 3455 21 sequelae sequela NNS cord-015021-pol2qm74 3455 22 . . . cord-015021-pol2qm74 3456 1 Increased increase VBN cord-015021-pol2qm74 3456 2 systemic systemic JJ cord-015021-pol2qm74 3456 3 levels level NNS cord-015021-pol2qm74 3456 4 of of IN cord-015021-pol2qm74 3456 5 this this DT cord-015021-pol2qm74 3456 6 cytoklne cytoklne NN cord-015021-pol2qm74 3456 7 seem seem VBP cord-015021-pol2qm74 3456 8 to to TO cord-015021-pol2qm74 3456 9 be be VB cord-015021-pol2qm74 3456 10 correlated correlate VBN cord-015021-pol2qm74 3456 11 with with IN cord-015021-pol2qm74 3456 12 severity severity NN cord-015021-pol2qm74 3456 13 of of IN cord-015021-pol2qm74 3456 14 sepsis sepsis NN cord-015021-pol2qm74 3456 15 and and CC cord-015021-pol2qm74 3456 16 outcome outcome NN cord-015021-pol2qm74 3456 17 . . . cord-015021-pol2qm74 3457 1 However however RB cord-015021-pol2qm74 3457 2 mechanism mechanism NN cord-015021-pol2qm74 3457 3 of of IN cord-015021-pol2qm74 3457 4 action action NN cord-015021-pol2qm74 3457 5 and and CC cord-015021-pol2qm74 3457 6 metabolism metabolism NN cord-015021-pol2qm74 3457 7 of of IN cord-015021-pol2qm74 3457 8 TNF TNF NNP cord-015021-pol2qm74 3457 9 - - HYPH cord-015021-pol2qm74 3457 10 G G NNP cord-015021-pol2qm74 3457 11 are be VBP cord-015021-pol2qm74 3457 12 not not RB cord-015021-pol2qm74 3457 13 fully fully RB cord-015021-pol2qm74 3457 14 understood understand VBN cord-015021-pol2qm74 3457 15 . . . cord-015021-pol2qm74 3458 1 In in IN cord-015021-pol2qm74 3458 2 most most JJS cord-015021-pol2qm74 3458 3 studies study NNS cord-015021-pol2qm74 3458 4 blood blood NN cord-015021-pol2qm74 3458 5 samples sample NNS cord-015021-pol2qm74 3458 6 for for IN cord-015021-pol2qm74 3458 7 TNF TNF NNP cord-015021-pol2qm74 3458 8 - - : cord-015021-pol2qm74 3458 9 a a DT cord-015021-pol2qm74 3458 10 determinations determination NNS cord-015021-pol2qm74 3458 11 are be VBP cord-015021-pol2qm74 3458 12 obtained obtain VBN cord-015021-pol2qm74 3458 13 either either CC cord-015021-pol2qm74 3458 14 by by IN cord-015021-pol2qm74 3458 15 peripheral peripheral JJ cord-015021-pol2qm74 3458 16 venipuncture venipuncture NN cord-015021-pol2qm74 3458 17 , , , cord-015021-pol2qm74 3458 18 a a DT cord-015021-pol2qm74 3458 19 central central JJ cord-015021-pol2qm74 3458 20 venous venous JJ cord-015021-pol2qm74 3458 21 catheter catheter NN cord-015021-pol2qm74 3458 22 or or CC cord-015021-pol2qm74 3458 23 by by IN cord-015021-pol2qm74 3458 24 an an DT cord-015021-pol2qm74 3458 25 indwelling indwell VBG cord-015021-pol2qm74 3458 26 arterial arterial JJ cord-015021-pol2qm74 3458 27 catheter catheter NN cord-015021-pol2qm74 3458 28 . . . cord-015021-pol2qm74 3459 1 Very very RB cord-015021-pol2qm74 3459 2 often often RB cord-015021-pol2qm74 3459 3 blood blood NN cord-015021-pol2qm74 3459 4 samples sample NNS cord-015021-pol2qm74 3459 5 are be VBP cord-015021-pol2qm74 3459 6 taken take VBN cord-015021-pol2qm74 3459 7 in in IN cord-015021-pol2qm74 3459 8 different different JJ cord-015021-pol2qm74 3459 9 manners manner NNS cord-015021-pol2qm74 3459 10 within within IN cord-015021-pol2qm74 3459 11 the the DT cord-015021-pol2qm74 3459 12 same same JJ cord-015021-pol2qm74 3459 13 study study NN cord-015021-pol2qm74 3459 14 . . . cord-015021-pol2qm74 3460 1 In in IN cord-015021-pol2qm74 3460 2 this this DT cord-015021-pol2qm74 3460 3 study study NN cord-015021-pol2qm74 3460 4 we -PRON- PRP cord-015021-pol2qm74 3460 5 measured measure VBD cord-015021-pol2qm74 3460 6 circulating circulate VBG cord-015021-pol2qm74 3460 7 TNF TNF NNP cord-015021-pol2qm74 3460 8 - - : cord-015021-pol2qm74 3460 9 a a NN cord-015021-pol2qm74 3460 10 and and CC cord-015021-pol2qm74 3460 11 the the DT cord-015021-pol2qm74 3460 12 amount amount NN cord-015021-pol2qm74 3460 13 of of IN cord-015021-pol2qm74 3460 14 TNF TNF NNP cord-015021-pol2qm74 3460 15 - - : cord-015021-pol2qm74 3460 16 a a DT cord-015021-pol2qm74 3460 17 released release VBN cord-015021-pol2qm74 3460 18 upon upon IN cord-015021-pol2qm74 3460 19 in in FW cord-015021-pol2qm74 3460 20 vitro vitro FW cord-015021-pol2qm74 3460 21 stimulation stimulation NN cord-015021-pol2qm74 3460 22 in in IN cord-015021-pol2qm74 3460 23 arterial arterial JJ cord-015021-pol2qm74 3460 24 and and CC cord-015021-pol2qm74 3460 25 central central JJ cord-015021-pol2qm74 3460 26 venous venous JJ cord-015021-pol2qm74 3460 27 blood blood NN cord-015021-pol2qm74 3460 28 . . . cord-015021-pol2qm74 3461 1 Methods method NNS cord-015021-pol2qm74 3461 2 : : : cord-015021-pol2qm74 3462 1 Heparlnized heparlnized JJ cord-015021-pol2qm74 3462 2 arterial arterial JJ cord-015021-pol2qm74 3462 3 and and CC cord-015021-pol2qm74 3462 4 central central JJ cord-015021-pol2qm74 3462 5 venous venous JJ cord-015021-pol2qm74 3462 6 blood blood NN cord-015021-pol2qm74 3462 7 samples sample NNS cord-015021-pol2qm74 3462 8 of of IN cord-015021-pol2qm74 3462 9 ten ten CD cord-015021-pol2qm74 3462 10 patients patient NNS cord-015021-pol2qm74 3462 11 ( ( -LRB- cord-015021-pol2qm74 3462 12 6 6 CD cord-015021-pol2qm74 3462 13 males male NNS cord-015021-pol2qm74 3462 14 , , , cord-015021-pol2qm74 3462 15 4 4 CD cord-015021-pol2qm74 3462 16 females female NNS cord-015021-pol2qm74 3462 17 , , , cord-015021-pol2qm74 3462 18 mean mean VB cord-015021-pol2qm74 3462 19 age age NN cord-015021-pol2qm74 3462 20 62+_14 62+_14 NNP cord-015021-pol2qm74 3462 21 ) ) -RRB- cord-015021-pol2qm74 3462 22 with with IN cord-015021-pol2qm74 3462 23 severe severe JJ cord-015021-pol2qm74 3462 24 sepsis sepsis NN cord-015021-pol2qm74 3463 1 ( ( -LRB- cord-015021-pol2qm74 3463 2 sepsis sepsis NN cord-015021-pol2qm74 3463 3 score score NN cord-015021-pol2qm74 3463 4 > > XX cord-015021-pol2qm74 3463 5 15 15 CD cord-015021-pol2qm74 3463 6 , , , cord-015021-pol2qm74 3463 7 Elebute Elebute NNP cord-015021-pol2qm74 3463 8 and and CC cord-015021-pol2qm74 3463 9 Stoner Stoner NNP cord-015021-pol2qm74 3463 10 } } -RRB- cord-015021-pol2qm74 3463 11 were be VBD cord-015021-pol2qm74 3463 12 drawn draw VBN cord-015021-pol2qm74 3463 13 on on IN cord-015021-pol2qm74 3463 14 day day NN cord-015021-pol2qm74 3463 15 1,3,6,8 1,3,6,8 CD cord-015021-pol2qm74 3463 16 , , , cord-015021-pol2qm74 3463 17 and and CC cord-015021-pol2qm74 3463 18 14 14 CD cord-015021-pol2qm74 3463 19 of of IN cord-015021-pol2qm74 3463 20 disease disease NN cord-015021-pol2qm74 3463 21 . . . cord-015021-pol2qm74 3464 1 Blood blood NN cord-015021-pol2qm74 3464 2 was be VBD cord-015021-pol2qm74 3464 3 immediately immediately RB cord-015021-pol2qm74 3464 4 placed place VBN cord-015021-pol2qm74 3464 5 on on IN cord-015021-pol2qm74 3464 6 ice ice NN cord-015021-pol2qm74 3464 7 and and CC cord-015021-pol2qm74 3464 8 processed process VBN cord-015021-pol2qm74 3464 9 within within IN cord-015021-pol2qm74 3464 10 1 1 CD cord-015021-pol2qm74 3464 11 hour hour NN cord-015021-pol2qm74 3464 12 . . . cord-015021-pol2qm74 3465 1 50 50 CD cord-015021-pol2qm74 3465 2 pl pl NNS cord-015021-pol2qm74 3465 3 of of IN cord-015021-pol2qm74 3465 4 whole whole JJ cord-015021-pol2qm74 3465 5 blood blood NN cord-015021-pol2qm74 3465 6 were be VBD cord-015021-pol2qm74 3465 7 incubated incubate VBN cord-015021-pol2qm74 3465 8 with with IN cord-015021-pol2qm74 3465 9 450 450 CD cord-015021-pol2qm74 3465 10 pl pl NNP cord-015021-pol2qm74 3465 11 RPMI RPMI NNP cord-015021-pol2qm74 3465 12 - - HYPH cord-015021-pol2qm74 3465 13 medium medium NN cord-015021-pol2qm74 3465 14 supplemented supplement VBN cord-015021-pol2qm74 3465 15 with with IN cord-015021-pol2qm74 3465 16 antibiotics antibiotic NNS cord-015021-pol2qm74 3465 17 and and CC cord-015021-pol2qm74 3465 18 L L NNP cord-015021-pol2qm74 3465 19 - - HYPH cord-015021-pol2qm74 3465 20 Glutamlne Glutamlne NNP cord-015021-pol2qm74 3465 21 or or CC cord-015021-pol2qm74 3465 22 with with IN cord-015021-pol2qm74 3465 23 400 400 CD cord-015021-pol2qm74 3465 24 pl pl NNS cord-015021-pol2qm74 3465 25 of of IN cord-015021-pol2qm74 3465 26 RPMI RPMI NNP cord-015021-pol2qm74 3465 27 - - HYPH cord-015021-pol2qm74 3465 28 medium medium NN cord-015021-pol2qm74 3465 29 and and CC cord-015021-pol2qm74 3465 30 50 50 CD cord-015021-pol2qm74 3465 31 pl pl NN cord-015021-pol2qm74 3465 32 phytohemagglutinin phytohemagglutinin NN cord-015021-pol2qm74 3465 33 ( ( -LRB- cord-015021-pol2qm74 3465 34 PHA PHA NNP cord-015021-pol2qm74 3465 35 ) ) -RRB- cord-015021-pol2qm74 3465 36 a a DT cord-015021-pol2qm74 3465 37 potent potent JJ cord-015021-pol2qm74 3465 38 mitogen mitogen NN cord-015021-pol2qm74 3465 39 . . . cord-015021-pol2qm74 3466 1 After after IN cord-015021-pol2qm74 3466 2 an an DT cord-015021-pol2qm74 3466 3 incubation incubation NN cord-015021-pol2qm74 3466 4 period period NN cord-015021-pol2qm74 3466 5 of of IN cord-015021-pol2qm74 3466 6 24 24 CD cord-015021-pol2qm74 3466 7 hours hour NNS cord-015021-pol2qm74 3466 8 samples sample NNS cord-015021-pol2qm74 3466 9 were be VBD cord-015021-pol2qm74 3466 10 centrifuged centrifuge VBN cord-015021-pol2qm74 3466 11 and and CC cord-015021-pol2qm74 3466 12 plasma plasma NN cord-015021-pol2qm74 3466 13 was be VBD cord-015021-pol2qm74 3466 14 harvested harvest VBN cord-015021-pol2qm74 3466 15 and and CC cord-015021-pol2qm74 3466 16 stored store VBN cord-015021-pol2qm74 3466 17 at at IN cord-015021-pol2qm74 3466 18 -30 -30 CD cord-015021-pol2qm74 3466 19 ° ° NN cord-015021-pol2qm74 3466 20 celsius celsiu NNS cord-015021-pol2qm74 3466 21 before before IN cord-015021-pol2qm74 3466 22 assessment assessment NN cord-015021-pol2qm74 3466 23 of of IN cord-015021-pol2qm74 3466 24 TNF TNF NNP cord-015021-pol2qm74 3466 25 - - : cord-015021-pol2qm74 3466 26 a a DT cord-015021-pol2qm74 3466 27 concentration concentration NN cord-015021-pol2qm74 3466 28 by by IN cord-015021-pol2qm74 3466 29 ELISA ELISA NNP cord-015021-pol2qm74 3466 30 . . . cord-015021-pol2qm74 3467 1 Statistical statistical JJ cord-015021-pol2qm74 3467 2 analysis analysis NN cord-015021-pol2qm74 3467 3 was be VBD cord-015021-pol2qm74 3467 4 performed perform VBN cord-015021-pol2qm74 3467 5 with with IN cord-015021-pol2qm74 3467 6 the the DT cord-015021-pol2qm74 3467 7 paired pair VBN cord-015021-pol2qm74 3467 8 Student Student NNP cord-015021-pol2qm74 3467 9 - - HYPH cord-015021-pol2qm74 3467 10 T T NNP cord-015021-pol2qm74 3467 11 - - HYPH cord-015021-pol2qm74 3467 12 test test NN cord-015021-pol2qm74 3467 13 . . . cord-015021-pol2qm74 3468 1 Results result NNS cord-015021-pol2qm74 3469 1 : : : cord-015021-pol2qm74 3469 2 We -PRON- PRP cord-015021-pol2qm74 3469 3 found find VBD cord-015021-pol2qm74 3469 4 a a DT cord-015021-pol2qm74 3469 5 significant significant JJ cord-015021-pol2qm74 3469 6 difference difference NN cord-015021-pol2qm74 3469 7 ( ( -LRB- cord-015021-pol2qm74 3469 8 p p NN cord-015021-pol2qm74 3469 9 < < XX cord-015021-pol2qm74 3469 10 0,05 0,05 XX cord-015021-pol2qm74 3469 11 ) ) -RRB- cord-015021-pol2qm74 3469 12 for for IN cord-015021-pol2qm74 3469 13 circulating circulate VBG cord-015021-pol2qm74 3469 14 mean mean NN cord-015021-pol2qm74 3470 1 arterial arterial JJ cord-015021-pol2qm74 3470 2 TNF TNF NNP cord-015021-pol2qm74 3470 3 - - : cord-015021-pol2qm74 3470 4 a a DT cord-015021-pol2qm74 3470 5 concentration concentration NN cord-015021-pol2qm74 3471 1 ( ( -LRB- cord-015021-pol2qm74 3471 2 237 237 CD cord-015021-pol2qm74 3471 3 pg pg NNP cord-015021-pol2qm74 3471 4 / / SYM cord-015021-pol2qm74 3471 5 ml ml NN cord-015021-pol2qm74 3471 6 _ _ NNP cord-015021-pol2qm74 3471 7 + + SYM cord-015021-pol2qm74 3471 8 34 34 CD cord-015021-pol2qm74 3471 9 SEM SEM NNP cord-015021-pol2qm74 3471 10 } } -RRB- cord-015021-pol2qm74 3471 11 and and CC cord-015021-pol2qm74 3471 12 central central JJ cord-015021-pol2qm74 3471 13 venous venous JJ cord-015021-pol2qm74 3471 14 TNF TNF NNP cord-015021-pol2qm74 3471 15 - - , cord-015021-pol2qm74 3471 16 a a DT cord-015021-pol2qm74 3472 1 ( ( -LRB- cord-015021-pol2qm74 3472 2 203 203 CD cord-015021-pol2qm74 3472 3 pg pg NN cord-015021-pol2qm74 3472 4 / / SYM cord-015021-pol2qm74 3472 5 ml ml NN cord-015021-pol2qm74 3472 6 + + CC cord-015021-pol2qm74 3472 7 _ _ NN cord-015021-pol2qm74 3472 8 29 29 CD cord-015021-pol2qm74 3472 9 SEM SEM NNP cord-015021-pol2qm74 3472 10 ) ) -RRB- cord-015021-pol2qm74 3472 11 . . . cord-015021-pol2qm74 3473 1 Upon upon IN cord-015021-pol2qm74 3473 2 in in FW cord-015021-pol2qm74 3473 3 vitro vitro FW cord-015021-pol2qm74 3473 4 stimulation stimulation NN cord-015021-pol2qm74 3473 5 there there EX cord-015021-pol2qm74 3473 6 was be VBD cord-015021-pol2qm74 3473 7 also also RB cord-015021-pol2qm74 3473 8 a a DT cord-015021-pol2qm74 3473 9 significant significant JJ cord-015021-pol2qm74 3473 10 difference difference NN cord-015021-pol2qm74 3473 11 ( ( -LRB- cord-015021-pol2qm74 3473 12 p p NN cord-015021-pol2qm74 3473 13 < < XX cord-015021-pol2qm74 3473 14 0,002 0,002 CD cord-015021-pol2qm74 3473 15 ) ) -RRB- cord-015021-pol2qm74 3473 16 between between IN cord-015021-pol2qm74 3473 17 released release VBN cord-015021-pol2qm74 3473 18 arterial arterial JJ cord-015021-pol2qm74 3473 19 TNF-~ TNF-~ NNP cord-015021-pol2qm74 3473 20 ' ' '' cord-015021-pol2qm74 3473 21 { { -LRB- cord-015021-pol2qm74 3473 22 746 746 CD cord-015021-pol2qm74 3473 23 pg pg NN cord-015021-pol2qm74 3473 24 / / SYM cord-015021-pol2qm74 3473 25 ml ml NN cord-015021-pol2qm74 3473 26 _ _ NN cord-015021-pol2qm74 3473 27 + + SYM cord-015021-pol2qm74 3473 28 88 88 CD cord-015021-pol2qm74 3473 29 SEM SEM NNP cord-015021-pol2qm74 3473 30 ) ) -RRB- cord-015021-pol2qm74 3473 31 and and CC cord-015021-pol2qm74 3473 32 venous venous JJ cord-015021-pol2qm74 3473 33 TNF TNF NNP cord-015021-pol2qm74 3473 34 - - , cord-015021-pol2qm74 3473 35 a a DT cord-015021-pol2qm74 3474 1 ( ( -LRB- cord-015021-pol2qm74 3474 2 637 637 CD cord-015021-pol2qm74 3474 3 pg pg NN cord-015021-pol2qm74 3474 4 / / SYM cord-015021-pol2qm74 3474 5 ml ml NN cord-015021-pol2qm74 3474 6 + + CC cord-015021-pol2qm74 3475 1 _ _ NNP cord-015021-pol2qm74 3475 2 76 76 CD cord-015021-pol2qm74 3475 3 SEMI semi JJ cord-015021-pol2qm74 3475 4 . . . cord-015021-pol2qm74 3476 1 Conclusions conclusion NNS cord-015021-pol2qm74 3476 2 : : : cord-015021-pol2qm74 3477 1 These these DT cord-015021-pol2qm74 3477 2 results result NNS cord-015021-pol2qm74 3477 3 are be VBP cord-015021-pol2qm74 3477 4 difficult difficult JJ cord-015021-pol2qm74 3477 5 to to TO cord-015021-pol2qm74 3477 6 interprete interprete VB cord-015021-pol2qm74 3477 7 but but CC cord-015021-pol2qm74 3477 8 could could MD cord-015021-pol2qm74 3477 9 reflect reflect VB cord-015021-pol2qm74 3477 10 the the DT cord-015021-pol2qm74 3477 11 influence influence NN cord-015021-pol2qm74 3477 12 of of IN cord-015021-pol2qm74 3477 13 paO pao JJ cord-015021-pol2qm74 3477 14 2 2 CD cord-015021-pol2qm74 3477 15 and and CC cord-015021-pol2qm74 3477 16 SaO SaO NNP cord-015021-pol2qm74 3477 17 2 2 CD cord-015021-pol2qm74 3477 18 on on IN cord-015021-pol2qm74 3477 19 TNF TNF NNP cord-015021-pol2qm74 3477 20 a a DT cord-015021-pol2qm74 3477 21 release release NN cord-015021-pol2qm74 3477 22 . . . cord-015021-pol2qm74 3478 1 It -PRON- PRP cord-015021-pol2qm74 3478 2 could could MD cord-015021-pol2qm74 3478 3 also also RB cord-015021-pol2qm74 3478 4 be be VB cord-015021-pol2qm74 3478 5 the the DT cord-015021-pol2qm74 3478 6 result result NN cord-015021-pol2qm74 3478 7 of of IN cord-015021-pol2qm74 3478 8 different different JJ cord-015021-pol2qm74 3478 9 concentrations concentration NNS cord-015021-pol2qm74 3478 10 of of IN cord-015021-pol2qm74 3478 11 TNF TNF NNP cord-015021-pol2qm74 3478 12 - - HYPH cord-015021-pol2qm74 3478 13 o o NN cord-015021-pol2qm74 3478 14 release release NN cord-015021-pol2qm74 3478 15 influencing influencing NN cord-015021-pol2qm74 3478 16 factors factor NNS cord-015021-pol2qm74 3478 17 like like IN cord-015021-pol2qm74 3478 18 for for IN cord-015021-pol2qm74 3478 19 example example NN cord-015021-pol2qm74 3478 20 endotoxin endotoxin NN cord-015021-pol2qm74 3478 21 , , , cord-015021-pol2qm74 3478 22 interferon interferon NN cord-015021-pol2qm74 3478 23 - - HYPH cord-015021-pol2qm74 3478 24 F f NN cord-015021-pol2qm74 3478 25 or or CC cord-015021-pol2qm74 3478 26 prostaglandin prostaglandin NN cord-015021-pol2qm74 3478 27 . . . cord-015021-pol2qm74 3479 1 A a DT cord-015021-pol2qm74 3479 2 possible possible JJ cord-015021-pol2qm74 3479 3 pulmonary pulmonary NN cord-015021-pol2qm74 3479 4 and/or and/or CC cord-015021-pol2qm74 3479 5 a a DT cord-015021-pol2qm74 3479 6 hepatic hepatic JJ cord-015021-pol2qm74 3479 7 metabolism metabolism NN cord-015021-pol2qm74 3479 8 of of IN cord-015021-pol2qm74 3479 9 TNF TNF NNP cord-015021-pol2qm74 3479 10 - - HYPH cord-015021-pol2qm74 3479 11 n n NNP cord-015021-pol2qm74 3479 12 and and CC cord-015021-pol2qm74 3479 13 TNF TNF NNP cord-015021-pol2qm74 3479 14 - - : cord-015021-pol2qm74 3479 15 a a DT cord-015021-pol2qm74 3479 16 producing produce VBG cord-015021-pol2qm74 3479 17 cells cell NNS cord-015021-pol2qm74 3479 18 can can MD cord-015021-pol2qm74 3479 19 not not RB cord-015021-pol2qm74 3479 20 be be VB cord-015021-pol2qm74 3479 21 ruled rule VBN cord-015021-pol2qm74 3479 22 out out RP cord-015021-pol2qm74 3479 23 . . . cord-015021-pol2qm74 3480 1 However however RB cord-015021-pol2qm74 3480 2 for for IN cord-015021-pol2qm74 3480 3 better well JJR cord-015021-pol2qm74 3480 4 interpretations interpretation NNS cord-015021-pol2qm74 3480 5 of of IN cord-015021-pol2qm74 3480 6 TNF TNF NNP cord-015021-pol2qm74 3480 7 - - : cord-015021-pol2qm74 3480 8 a a DT cord-015021-pol2qm74 3480 9 release release NN cord-015021-pol2qm74 3480 10 in in IN cord-015021-pol2qm74 3480 11 septic septic JJ cord-015021-pol2qm74 3480 12 states state NNS cord-015021-pol2qm74 3480 13 it -PRON- PRP cord-015021-pol2qm74 3480 14 is be VBZ cord-015021-pol2qm74 3480 15 necessary necessary JJ cord-015021-pol2qm74 3480 16 to to TO cord-015021-pol2qm74 3480 17 use use VB cord-015021-pol2qm74 3480 18 either either CC cord-015021-pol2qm74 3480 19 arterial arterial JJ cord-015021-pol2qm74 3480 20 or or CC cord-015021-pol2qm74 3480 21 venous venous JJ cord-015021-pol2qm74 3480 22 blood blood NN cord-015021-pol2qm74 3480 23 samples sample NNS cord-015021-pol2qm74 3480 24 . . . cord-015021-pol2qm74 3481 1 Early early JJ cord-015021-pol2qm74 3481 2 inflammatory inflammatory JJ cord-015021-pol2qm74 3481 3 processes process NNS cord-015021-pol2qm74 3481 4 following follow VBG cord-015021-pol2qm74 3481 5 trauma trauma NN cord-015021-pol2qm74 3482 1 and/or and/or CC cord-015021-pol2qm74 3482 2 infections infection NNS cord-015021-pol2qm74 3482 3 were be VBD cord-015021-pol2qm74 3482 4 found find VBN cord-015021-pol2qm74 3482 5 to to TO cord-015021-pol2qm74 3482 6 be be VB cord-015021-pol2qm74 3482 7 associated associate VBN cord-015021-pol2qm74 3482 8 with with IN cord-015021-pol2qm74 3482 9 the the DT cord-015021-pol2qm74 3482 10 secretion secretion NN cord-015021-pol2qm74 3482 11 of of IN cord-015021-pol2qm74 3482 12 high high JJ cord-015021-pol2qm74 3482 13 amounts amount NNS cord-015021-pol2qm74 3482 14 of of IN cord-015021-pol2qm74 3482 15 proinflammatory proinflammatory JJ cord-015021-pol2qm74 3482 16 cytokines cytokine NNS cord-015021-pol2qm74 3482 17 . . . cord-015021-pol2qm74 3483 1 Besides besides IN cord-015021-pol2qm74 3483 2 intedeukin intedeukin NNP cord-015021-pol2qm74 3483 3 - - HYPH cord-015021-pol2qm74 3483 4 t t NNP cord-015021-pol2qm74 3483 5 ( ( -LRB- cord-015021-pol2qm74 3483 6 IL-1 IL-1 NNP cord-015021-pol2qm74 3483 7 ) ) -RRB- cord-015021-pol2qm74 3483 8 , , , cord-015021-pol2qm74 3483 9 tumor tumor NN cord-015021-pol2qm74 3483 10 necrosis necrosis NN cord-015021-pol2qm74 3483 11 factor factor NN cord-015021-pol2qm74 3483 12 - - : cord-015021-pol2qm74 3483 13 a a DT cord-015021-pol2qm74 3483 14 ( ( -LRB- cord-015021-pol2qm74 3483 15 TNF TNF NNP cord-015021-pol2qm74 3483 16 - - HYPH cord-015021-pol2qm74 3483 17 c c NN cord-015021-pol2qm74 3483 18 0 0 CD cord-015021-pol2qm74 3483 19 and and CC cord-015021-pol2qm74 3483 20 interleukin-8 interleukin-8 NNP cord-015021-pol2qm74 3483 21 ( ( -LRB- cord-015021-pol2qm74 3483 22 IL-8 IL-8 NNP cord-015021-pol2qm74 3483 23 ) ) -RRB- cord-015021-pol2qm74 3483 24 the the DT cord-015021-pol2qm74 3483 25 multifunctional multifunctional JJ cord-015021-pol2qm74 3483 26 cytokine cytokine NN cord-015021-pol2qm74 3483 27 intedeukin-6 intedeukin-6 NNP cord-015021-pol2qm74 3483 28 ( ( -LRB- cord-015021-pol2qm74 3483 29 IL-6 IL-6 NNP cord-015021-pol2qm74 3483 30 ) ) -RRB- cord-015021-pol2qm74 3483 31 was be VBD cord-015021-pol2qm74 3483 32 described describe VBN cord-015021-pol2qm74 3483 33 to to TO cord-015021-pol2qm74 3483 34 be be VB cord-015021-pol2qm74 3483 35 a a DT cord-015021-pol2qm74 3483 36 central central JJ cord-015021-pol2qm74 3483 37 regulatory regulatory JJ cord-015021-pol2qm74 3483 38 element element NN cord-015021-pol2qm74 3483 39 of of IN cord-015021-pol2qm74 3483 40 the the DT cord-015021-pol2qm74 3483 41 primary primary JJ cord-015021-pol2qm74 3483 42 cellular cellular JJ cord-015021-pol2qm74 3483 43 and and CC cord-015021-pol2qm74 3483 44 humeral humeral JJ cord-015021-pol2qm74 3483 45 defence defence NN cord-015021-pol2qm74 3483 46 reaction reaction NN cord-015021-pol2qm74 3483 47 . . . cord-015021-pol2qm74 3484 1 The the DT cord-015021-pol2qm74 3484 2 previously previously RB cord-015021-pol2qm74 3484 3 described describe VBN cord-015021-pol2qm74 3484 4 close close JJ cord-015021-pol2qm74 3484 5 temporal temporal JJ cord-015021-pol2qm74 3484 6 correlation correlation NN cord-015021-pol2qm74 3484 7 of of IN cord-015021-pol2qm74 3484 8 pathologically pathologically RB cord-015021-pol2qm74 3484 9 elevated elevated JJ cord-015021-pol2qm74 3484 10 IL-6-concentrations il-6-concentration NNS cord-015021-pol2qm74 3484 11 and and CC cord-015021-pol2qm74 3484 12 the the DT cord-015021-pol2qm74 3484 13 extracellulary extracellulary JJ cord-015021-pol2qm74 3484 14 release release NN cord-015021-pol2qm74 3484 15 of of IN cord-015021-pol2qm74 3484 16 lysosomal lysosomal JJ cord-015021-pol2qm74 3484 17 enzymes enzyme NNS cord-015021-pol2qm74 3484 18 from from IN cord-015021-pol2qm74 3484 19 activated activate VBN cord-015021-pol2qm74 3484 20 pelymorphnuclear pelymorphnuclear NNP cord-015021-pol2qm74 3484 21 neutrophils neutrophil NNS cord-015021-pol2qm74 3484 22 suggests suggest VBZ cord-015021-pol2qm74 3484 23 , , , cord-015021-pol2qm74 3484 24 that that IN cord-015021-pol2qm74 3484 25 IL-6 IL-6 NNP cord-015021-pol2qm74 3484 26 may may MD cord-015021-pol2qm74 3484 27 be be VB cord-015021-pol2qm74 3484 28 a a DT cord-015021-pol2qm74 3484 29 potential potential JJ cord-015021-pol2qm74 3484 30 substrate substrate NN cord-015021-pol2qm74 3484 31 of of IN cord-015021-pol2qm74 3484 32 these these DT cord-015021-pol2qm74 3484 33 preteases pretease NNS cord-015021-pol2qm74 3484 34 . . . cord-015021-pol2qm74 3485 1 The the DT cord-015021-pol2qm74 3485 2 serine serine NN cord-015021-pol2qm74 3485 3 preteases pretease NNS cord-015021-pol2qm74 3485 4 elastase elastase NN cord-015021-pol2qm74 3485 5 ( ( -LRB- cord-015021-pol2qm74 3485 6 EC EC NNP cord-015021-pol2qm74 3485 7 3.4.21.37 3.4.21.37 CD cord-015021-pol2qm74 3485 8 ) ) -RRB- cord-015021-pol2qm74 3485 9 and and CC cord-015021-pol2qm74 3485 10 cathepsin cathepsin NN cord-015021-pol2qm74 3485 11 G g NN cord-015021-pol2qm74 3485 12 ( ( -LRB- cord-015021-pol2qm74 3485 13 EC EC NNP cord-015021-pol2qm74 3485 14 3.4.21.20 3.4.21.20 CD cord-015021-pol2qm74 3485 15 ) ) -RRB- cord-015021-pol2qm74 3485 16 derived derive VBN cord-015021-pol2qm74 3485 17 from from IN cord-015021-pol2qm74 3485 18 the the DT cord-015021-pol2qm74 3485 19 azurophilic azurophilic JJ cord-015021-pol2qm74 3485 20 granules granule NNS cord-015021-pol2qm74 3485 21 were be VBD cord-015021-pol2qm74 3485 22 assumed assume VBN cord-015021-pol2qm74 3485 23 to to TO cord-015021-pol2qm74 3485 24 be be VB cord-015021-pol2qm74 3485 25 mainly mainly RB cord-015021-pol2qm74 3485 26 involved involve VBN cord-015021-pol2qm74 3485 27 in in IN cord-015021-pol2qm74 3485 28 unspecific unspecific JJ cord-015021-pol2qm74 3485 29 proteolysis proteolysis NN cord-015021-pol2qm74 3485 30 at at IN cord-015021-pol2qm74 3485 31 sites site NNS cord-015021-pol2qm74 3485 32 of of IN cord-015021-pol2qm74 3485 33 inflammation inflammation NN cord-015021-pol2qm74 3485 34 by by IN cord-015021-pol2qm74 3485 35 cleavage cleavage NN cord-015021-pol2qm74 3485 36 of of IN cord-015021-pol2qm74 3485 37 structural structural JJ cord-015021-pol2qm74 3485 38 as as RB cord-015021-pol2qm74 3485 39 well well RB cord-015021-pol2qm74 3485 40 as as IN cord-015021-pol2qm74 3485 41 soluble soluble JJ cord-015021-pol2qm74 3485 42 proteins protein NNS cord-015021-pol2qm74 3485 43 at at IN cord-015021-pol2qm74 3485 44 random random JJ cord-015021-pol2qm74 3485 45 sites site NNS cord-015021-pol2qm74 3485 46 , , , cord-015021-pol2qm74 3485 47 if if IN cord-015021-pol2qm74 3485 48 the the DT cord-015021-pol2qm74 3485 49 inhibitory inhibitory JJ cord-015021-pol2qm74 3485 50 potential potential NN cord-015021-pol2qm74 3485 51 is be VBZ cord-015021-pol2qm74 3485 52 decreased decrease VBN cord-015021-pol2qm74 3485 53 . . . cord-015021-pol2qm74 3486 1 The the DT cord-015021-pol2qm74 3486 2 possible possible JJ cord-015021-pol2qm74 3486 3 proteolytic proteolytic JJ cord-015021-pol2qm74 3486 4 activity activity NN cord-015021-pol2qm74 3486 5 of of IN cord-015021-pol2qm74 3486 6 elastase elastase NN cord-015021-pol2qm74 3486 7 and and CC cord-015021-pol2qm74 3486 8 cathepsin cathepsin NN cord-015021-pol2qm74 3486 9 G g NN cord-015021-pol2qm74 3486 10 toward toward IN cord-015021-pol2qm74 3486 11 the the DT cord-015021-pol2qm74 3486 12 proinflammatory proinflammatory JJ cord-015021-pol2qm74 3486 13 cytokine cytokine NN cord-015021-pol2qm74 3486 14 interleukin-6 interleukin-6 NNP cord-015021-pol2qm74 3487 1 ( ( -LRB- cord-015021-pol2qm74 3487 2 IL-6 IL-6 NNP cord-015021-pol2qm74 3487 3 ) ) -RRB- cord-015021-pol2qm74 3487 4 was be VBD cord-015021-pol2qm74 3487 5 investigated investigate VBN cord-015021-pol2qm74 3487 6 . . . cord-015021-pol2qm74 3488 1 The the DT cord-015021-pol2qm74 3488 2 addition addition NN cord-015021-pol2qm74 3488 3 of of IN cord-015021-pol2qm74 3488 4 purified purify VBN cord-015021-pol2qm74 3488 5 neutrephil neutrephil JJ cord-015021-pol2qm74 3488 6 elastase elastase NN cord-015021-pol2qm74 3488 7 and and CC cord-015021-pol2qm74 3488 8 cathepsin cathepsin NN cord-015021-pol2qm74 3488 9 G g NN cord-015021-pol2qm74 3488 10 to to IN cord-015021-pol2qm74 3488 11 recombinant recombinant JJ cord-015021-pol2qm74 3488 12 human human NN cord-015021-pol2qm74 3488 13 IL-6 IL-6 NNP cord-015021-pol2qm74 3488 14 leads lead VBZ cord-015021-pol2qm74 3488 15 to to IN cord-015021-pol2qm74 3488 16 a a DT cord-015021-pol2qm74 3488 17 rapid rapid JJ cord-015021-pol2qm74 3488 18 sequential sequential JJ cord-015021-pol2qm74 3488 19 degradation degradation NN cord-015021-pol2qm74 3488 20 in in IN cord-015021-pol2qm74 3488 21 vitro vitro FW cord-015021-pol2qm74 3488 22 . . . cord-015021-pol2qm74 3489 1 At at RB cord-015021-pol2qm74 3489 2 least least RBS cord-015021-pol2qm74 3489 3 two two CD cord-015021-pol2qm74 3489 4 intermediate intermediate JJ cord-015021-pol2qm74 3489 5 products product NNS cord-015021-pol2qm74 3489 6 could could MD cord-015021-pol2qm74 3489 7 be be VB cord-015021-pol2qm74 3489 8 detected detect VBN cord-015021-pol2qm74 3489 9 by by IN cord-015021-pol2qm74 3489 10 silver silver JJ cord-015021-pol2qm74 3489 11 staining staining NN cord-015021-pol2qm74 3489 12 and and CC cord-015021-pol2qm74 3489 13 western western JJ cord-015021-pol2qm74 3489 14 blotting blotting NN cord-015021-pol2qm74 3489 15 following follow VBG cord-015021-pol2qm74 3489 16 protein protein NN cord-015021-pol2qm74 3489 17 separation separation NN cord-015021-pol2qm74 3489 18 under under IN cord-015021-pol2qm74 3489 19 reducing reduce VBG cord-015021-pol2qm74 3489 20 conditions condition NNS cord-015021-pol2qm74 3489 21 . . . cord-015021-pol2qm74 3490 1 The the DT cord-015021-pol2qm74 3490 2 serine serine JJ cord-015021-pol2qm74 3490 3 protease protease NN cord-015021-pol2qm74 3490 4 inhibitor inhibitor NN cord-015021-pol2qm74 3490 5 G G NNP cord-015021-pol2qm74 3490 6 - - HYPH cord-015021-pol2qm74 3490 7 anitrypsin anitrypsin NNP cord-015021-pol2qm74 3490 8 was be VBD cord-015021-pol2qm74 3490 9 shown show VBN cord-015021-pol2qm74 3490 10 to to TO cord-015021-pol2qm74 3490 11 prevent prevent VB cord-015021-pol2qm74 3490 12 the the DT cord-015021-pol2qm74 3490 13 proteolytical proteolytical JJ cord-015021-pol2qm74 3490 14 degradation degradation NN cord-015021-pol2qm74 3490 15 of of IN cord-015021-pol2qm74 3490 16 intedeukin-6 intedeukin-6 NNP cord-015021-pol2qm74 3490 17 . . . cord-015021-pol2qm74 3491 1 Furthermore furthermore RB cord-015021-pol2qm74 3491 2 the the DT cord-015021-pol2qm74 3491 3 loss loss NN cord-015021-pol2qm74 3491 4 of of IN cord-015021-pol2qm74 3491 5 the the DT cord-015021-pol2qm74 3491 6 biological biological JJ cord-015021-pol2qm74 3491 7 activity activity NN cord-015021-pol2qm74 3491 8 of of IN cord-015021-pol2qm74 3491 9 both both DT cord-015021-pol2qm74 3491 10 , , , cord-015021-pol2qm74 3491 11 recombinant recombinant JJ cord-015021-pol2qm74 3491 12 and and CC cord-015021-pol2qm74 3491 13 natural natural JJ cord-015021-pol2qm74 3491 14 human human JJ cord-015021-pol2qm74 3491 15 IL-6 IL-6 NNP cord-015021-pol2qm74 3491 16 , , , cord-015021-pol2qm74 3491 17 was be VBD cord-015021-pol2qm74 3491 18 demonstrated demonstrate VBN cord-015021-pol2qm74 3491 19 by by IN cord-015021-pol2qm74 3491 20 determination determination NN cord-015021-pol2qm74 3491 21 of of IN cord-015021-pol2qm74 3491 22 the the DT cord-015021-pol2qm74 3491 23 capacity capacity NN cord-015021-pol2qm74 3491 24 of of IN cord-015021-pol2qm74 3491 25 protease protease NN cord-015021-pol2qm74 3491 26 - - HYPH cord-015021-pol2qm74 3491 27 treated treat VBN cord-015021-pol2qm74 3491 28 IL-6 IL-6 NNP cord-015021-pol2qm74 3491 29 to to TO cord-015021-pol2qm74 3491 30 stimulate stimulate VB cord-015021-pol2qm74 3491 31 hybddoma hybddoma NNP cord-015021-pol2qm74 3491 32 growth growth NN cord-015021-pol2qm74 3491 33 ( ( -LRB- cord-015021-pol2qm74 3491 34 7TD1 7td1 CD cord-015021-pol2qm74 3491 35 bioassay bioassay NN cord-015021-pol2qm74 3491 36 ) ) -RRB- cord-015021-pol2qm74 3491 37 . . . cord-015021-pol2qm74 3492 1 These these DT cord-015021-pol2qm74 3492 2 data datum NNS cord-015021-pol2qm74 3492 3 suggest suggest VBP cord-015021-pol2qm74 3492 4 a a DT cord-015021-pol2qm74 3492 5 possible possible JJ cord-015021-pol2qm74 3492 6 downregulation downregulation NN cord-015021-pol2qm74 3492 7 of of IN cord-015021-pol2qm74 3492 8 pathologically pathologically RB cord-015021-pol2qm74 3492 9 elevated elevate VBN cord-015021-pol2qm74 3492 10 IL-6 IL-6 NNP cord-015021-pol2qm74 3492 11 levels level NNS cord-015021-pol2qm74 3492 12 by by IN cord-015021-pol2qm74 3492 13 proteolytic proteolytic JJ cord-015021-pol2qm74 3492 14 activity activity NN cord-015021-pol2qm74 3492 15 of of IN cord-015021-pol2qm74 3492 16 extracellulary extracellulary JJ cord-015021-pol2qm74 3492 17 released release VBN cord-015021-pol2qm74 3492 18 enzymes enzyme NNS cord-015021-pol2qm74 3492 19 at at IN cord-015021-pol2qm74 3492 20 sites site NNS cord-015021-pol2qm74 3492 21 of of IN cord-015021-pol2qm74 3492 22 inflammation inflammation NN cord-015021-pol2qm74 3492 23 . . . cord-015021-pol2qm74 3493 1 The the DT cord-015021-pol2qm74 3493 2 aim aim NN cord-015021-pol2qm74 3493 3 of of IN cord-015021-pol2qm74 3493 4 the the DT cord-015021-pol2qm74 3493 5 study study NN cord-015021-pol2qm74 3493 6 was be VBD cord-015021-pol2qm74 3493 7 to to TO cord-015021-pol2qm74 3493 8 compare compare VB cord-015021-pol2qm74 3493 9 circulating circulate VBG cord-015021-pol2qm74 3493 10 levels level NNS cord-015021-pol2qm74 3493 11 of of IN cord-015021-pol2qm74 3493 12 three three CD cord-015021-pol2qm74 3493 13 cytokines cytokine NNS cord-015021-pol2qm74 3493 14 -IL-1 -il-1 XX cord-015021-pol2qm74 3493 15 , , , cord-015021-pol2qm74 3493 16 IL-6 IL-6 NNP cord-015021-pol2qm74 3493 17 , , , cord-015021-pol2qm74 3493 18 11_-8 11_-8 CD cord-015021-pol2qm74 3493 19 -between -between SYM cord-015021-pol2qm74 3493 20 critically critically RB cord-015021-pol2qm74 3493 21 ill ill JJ cord-015021-pol2qm74 3493 22 subjects subject NNS cord-015021-pol2qm74 3493 23 who who WP cord-015021-pol2qm74 3493 24 developed develop VBD cord-015021-pol2qm74 3493 25 Gram gram NN cord-015021-pol2qm74 3493 26 - - HYPH cord-015021-pol2qm74 3493 27 negative negative JJ cord-015021-pol2qm74 3493 28 sepsis sepsis NN cord-015021-pol2qm74 3493 29 and and CC cord-015021-pol2qm74 3493 30 who who WP cord-015021-pol2qm74 3493 31 did do VBD cord-015021-pol2qm74 3493 32 not not RB cord-015021-pol2qm74 3493 33 . . . cord-015021-pol2qm74 3494 1 MATERIALS materials NN cord-015021-pol2qm74 3494 2 AND and CC cord-015021-pol2qm74 3494 3 METHODS method NNS cord-015021-pol2qm74 3494 4 : : : cord-015021-pol2qm74 3495 1 The the DT cord-015021-pol2qm74 3495 2 patient patient JJ cord-015021-pol2qm74 3495 3 population population NN cord-015021-pol2qm74 3495 4 consisted consist VBD cord-015021-pol2qm74 3495 5 of of IN cord-015021-pol2qm74 3495 6 39 39 CD cord-015021-pol2qm74 3495 7 patients patient NNS cord-015021-pol2qm74 3495 8 admitted admit VBN cord-015021-pol2qm74 3495 9 to to IN cord-015021-pol2qm74 3495 10 an an DT cord-015021-pol2qm74 3495 11 Intensive Intensive NNP cord-015021-pol2qm74 3495 12 Cars Cars NNPS cord-015021-pol2qm74 3495 13 Unit Unit NNP cord-015021-pol2qm74 3495 14 , , , cord-015021-pol2qm74 3495 15 with with IN cord-015021-pol2qm74 3495 16 different different JJ cord-015021-pol2qm74 3495 17 underlying underlie VBG cord-015021-pol2qm74 3495 18 diseases disease NNS cord-015021-pol2qm74 3495 19 . . . cord-015021-pol2qm74 3496 1 Sepsis sepsis NN cord-015021-pol2qm74 3496 2 diagnosis diagnosis NN cord-015021-pol2qm74 3496 3 was be VBD cord-015021-pol2qm74 3496 4 given give VBN cord-015021-pol2qm74 3496 5 according accord VBG cord-015021-pol2qm74 3496 6 to to IN cord-015021-pol2qm74 3496 7 pre pre JJ cord-015021-pol2qm74 3496 8 - - JJ cord-015021-pol2qm74 3496 9 estabilished estabilished JJ cord-015021-pol2qm74 3496 10 cdteda cdteda NN cord-015021-pol2qm74 3496 11 . . . cord-015021-pol2qm74 3497 1 Nineteen nineteen CD cord-015021-pol2qm74 3497 2 cases case NNS cord-015021-pol2qm74 3497 3 were be VBD cord-015021-pol2qm74 3497 4 enrolled enrol VBN cord-015021-pol2qm74 3497 5 in in IN cord-015021-pol2qm74 3497 6 sepsis sepsis NN cord-015021-pol2qm74 3497 7 group group NN cord-015021-pol2qm74 3497 8 , , , cord-015021-pol2qm74 3497 9 twenty twenty CD cord-015021-pol2qm74 3497 10 in in IN cord-015021-pol2qm74 3497 11 control control NN cord-015021-pol2qm74 3497 12 group group NN cord-015021-pol2qm74 3497 13 . . . cord-015021-pol2qm74 3498 1 Serum serum NN cord-015021-pol2qm74 3498 2 sampling sampling NN cord-015021-pol2qm74 3498 3 was be VBD cord-015021-pol2qm74 3498 4 collected collect VBN cord-015021-pol2qm74 3498 5 in in IN cord-015021-pol2qm74 3498 6 sterile sterile JJ cord-015021-pol2qm74 3498 7 tubes tube NNS cord-015021-pol2qm74 3498 8 at at IN cord-015021-pol2qm74 3498 9 study study NN cord-015021-pol2qm74 3498 10 entry entry NN cord-015021-pol2qm74 3498 11 and and CC cord-015021-pol2qm74 3498 12 every every DT cord-015021-pol2qm74 3498 13 three three CD cord-015021-pol2qm74 3498 14 days day NNS cord-015021-pol2qm74 3498 15 until until IN cord-015021-pol2qm74 3498 16 study study NN cord-015021-pol2qm74 3498 17 dismissal dismissal NN cord-015021-pol2qm74 3498 18 . . . cord-015021-pol2qm74 3499 1 Serum serum NN cord-015021-pol2qm74 3499 2 concentrations concentration NNS cord-015021-pol2qm74 3499 3 of of IN cord-015021-pol2qm74 3500 1 IL-1 IL-1 NNP cord-015021-pol2qm74 3500 2 , , , cord-015021-pol2qm74 3500 3 11_-6 11_-6 CD cord-015021-pol2qm74 3500 4 and and CC cord-015021-pol2qm74 3500 5 IL-8 IL-8 NNP cord-015021-pol2qm74 3500 6 were be VBD cord-015021-pol2qm74 3500 7 measured measure VBN cord-015021-pol2qm74 3500 8 using use VBG cord-015021-pol2qm74 3500 9 commercially commercially RB cord-015021-pol2qm74 3500 10 available available JJ cord-015021-pol2qm74 3500 11 test test NN cord-015021-pol2qm74 3500 12 kits kit NNS cord-015021-pol2qm74 3500 13 , , , cord-015021-pol2qm74 3500 14 based base VBN cord-015021-pol2qm74 3500 15 on on IN cord-015021-pol2qm74 3500 16 the the DT cord-015021-pol2qm74 3500 17 dual dual JJ cord-015021-pol2qm74 3500 18 immunometric immunometric NNP cord-015021-pol2qm74 3500 19 sandwich sandwich NN cord-015021-pol2qm74 3500 20 principle principle NN cord-015021-pol2qm74 3500 21 . . . cord-015021-pol2qm74 3501 1 RESULTS result NNS cord-015021-pol2qm74 3501 2 : : : cord-015021-pol2qm74 3502 1 The the DT cord-015021-pol2qm74 3502 2 causative causative JJ cord-015021-pol2qm74 3502 3 patogens patogen NNS cord-015021-pol2qm74 3502 4 of of IN cord-015021-pol2qm74 3502 5 sepsis sepsis NN cord-015021-pol2qm74 3502 6 were be VBD cord-015021-pol2qm74 3502 7 : : : cord-015021-pol2qm74 3502 8 Pseudomonas Pseudomonas NNP cord-015021-pol2qm74 3502 9 aeruginosa aeruginosa NN cord-015021-pol2qm74 3502 10 , , , cord-015021-pol2qm74 3502 11 Acinetobacter Acinetobacter NNP cord-015021-pol2qm74 3502 12 , , , cord-015021-pol2qm74 3503 1 Eseherichia Eseherichia NNP cord-015021-pol2qm74 3503 2 co co VBD cord-015021-pol2qm74 3503 3 ~ ~ NNP cord-015021-pol2qm74 3503 4 i i PRP cord-015021-pol2qm74 3503 5 , , , cord-015021-pol2qm74 3503 6 Serratia Serratia NNP cord-015021-pol2qm74 3503 7 marceseens marceseen NNS cord-015021-pol2qm74 3503 8 , , , cord-015021-pol2qm74 3503 9 Proteus Proteus NNP cord-015021-pol2qm74 3503 10 mirobilis mirobilis NNP cord-015021-pol2qm74 3503 11 and and CC cord-015021-pol2qm74 3503 12 Citrobacter Citrobacter NNP cord-015021-pol2qm74 3503 13 freundL freundL NNP cord-015021-pol2qm74 3504 1 The the DT cord-015021-pol2qm74 3504 2 time time NN cord-015021-pol2qm74 3504 3 of of IN cord-015021-pol2qm74 3504 4 observation observation NN cord-015021-pol2qm74 3504 5 was be VBD cord-015021-pol2qm74 3504 6 equal equal JJ cord-015021-pol2qm74 3504 7 to to IN cord-015021-pol2qm74 3504 8 12 12 CD cord-015021-pol2qm74 3504 9 days day NNS cord-015021-pol2qm74 3504 10 , , , cord-015021-pol2qm74 3504 11 for for IN cord-015021-pol2qm74 3504 12 a a DT cord-015021-pol2qm74 3504 13 total total NN cord-015021-pol2qm74 3504 14 of of IN cord-015021-pol2qm74 3504 15 four four CD cord-015021-pol2qm74 3504 16 tests test NNS cord-015021-pol2qm74 3504 17 performed perform VBN cord-015021-pol2qm74 3504 18 ( ( -LRB- cord-015021-pol2qm74 3504 19 to to TO cord-015021-pol2qm74 3504 20 , , , cord-015021-pol2qm74 3504 21 tl tl NNP cord-015021-pol2qm74 3504 22 , , , cord-015021-pol2qm74 3504 23 t2 t2 NNP cord-015021-pol2qm74 3504 24 , , , cord-015021-pol2qm74 3504 25 t3 t3 NNP cord-015021-pol2qm74 3504 26 ) ) -RRB- cord-015021-pol2qm74 3504 27 . . . cord-015021-pol2qm74 3505 1 I1.-1 I1.-1 NNP cord-015021-pol2qm74 3505 2 was be VBD cord-015021-pol2qm74 3505 3 not not RB cord-015021-pol2qm74 3505 4 detected detect VBN cord-015021-pol2qm74 3505 5 in in IN cord-015021-pol2qm74 3505 6 any any DT cord-015021-pol2qm74 3505 7 samples sample NNS cord-015021-pol2qm74 3505 8 . . . cord-015021-pol2qm74 3506 1 The the DT cord-015021-pol2qm74 3506 2 serological serological JJ cord-015021-pol2qm74 3506 3 profiles profile NNS cord-015021-pol2qm74 3506 4 of of IN cord-015021-pol2qm74 3506 5 the the DT cord-015021-pol2qm74 3506 6 two two CD cord-015021-pol2qm74 3506 7 cytokines cytokine NNS cord-015021-pol2qm74 3506 8 11.-6 11.-6 CD cord-015021-pol2qm74 3506 9 and and CC cord-015021-pol2qm74 3506 10 11_-8 11_-8 CD cord-015021-pol2qm74 3506 11 were be VBD cord-015021-pol2qm74 3506 12 similar similar JJ cord-015021-pol2qm74 3506 13 ; ; : cord-015021-pol2qm74 3506 14 augmented augment VBN cord-015021-pol2qm74 3506 15 levels level NNS cord-015021-pol2qm74 3506 16 were be VBD cord-015021-pol2qm74 3506 17 found find VBN cord-015021-pol2qm74 3506 18 at at IN cord-015021-pol2qm74 3506 19 study study NN cord-015021-pol2qm74 3506 20 entry entry NN cord-015021-pol2qm74 3506 21 and and CC cord-015021-pol2qm74 3506 22 throughout throughout IN cord-015021-pol2qm74 3506 23 the the DT cord-015021-pol2qm74 3506 24 observation observation NN cord-015021-pol2qm74 3506 25 period period NN cord-015021-pol2qm74 3506 26 , , , cord-015021-pol2qm74 3506 27 peaking peak VBG cord-015021-pol2qm74 3506 28 at at IN cord-015021-pol2qm74 3506 29 t3 t3 NNP cord-015021-pol2qm74 3506 30 and and CC cord-015021-pol2qm74 3506 31 decreasing decrease VBG cord-015021-pol2qm74 3506 32 at at IN cord-015021-pol2qm74 3506 33 t4 t4 NNP cord-015021-pol2qm74 3506 34 . . . cord-015021-pol2qm74 3507 1 However however RB cord-015021-pol2qm74 3507 2 , , , cord-015021-pol2qm74 3507 3 in in IN cord-015021-pol2qm74 3507 4 patients patient NNS cord-015021-pol2qm74 3507 5 with with IN cord-015021-pol2qm74 3507 6 sepsis sepsis NN cord-015021-pol2qm74 3507 7 , , , cord-015021-pol2qm74 3507 8 IL-6 IL-6 NNP cord-015021-pol2qm74 3507 9 and and CC cord-015021-pol2qm74 3507 10 11_-8 11_-8 CD cord-015021-pol2qm74 3507 11 concentrations concentration NNS cord-015021-pol2qm74 3507 12 were be VBD cord-015021-pol2qm74 3507 13 significantly significantly RB cord-015021-pol2qm74 3507 14 higher high JJR cord-015021-pol2qm74 3507 15 in in IN cord-015021-pol2qm74 3507 16 respect respect NN cord-015021-pol2qm74 3507 17 to to IN cord-015021-pol2qm74 3507 18 control control NN cord-015021-pol2qm74 3507 19 group group NN cord-015021-pol2qm74 3507 20 . . . cord-015021-pol2qm74 3508 1 CONCLUSION conclusion NN cord-015021-pol2qm74 3508 2 : : : cord-015021-pol2qm74 3509 1 Our -PRON- PRP$ cord-015021-pol2qm74 3509 2 observations observation NNS cord-015021-pol2qm74 3509 3 shown show VBN cord-015021-pol2qm74 3509 4 that that IN cord-015021-pol2qm74 3509 5 in in IN cord-015021-pol2qm74 3509 6 ICU ICU NNP cord-015021-pol2qm74 3509 7 patients patient NNS cord-015021-pol2qm74 3509 8 increased increase VBD cord-015021-pol2qm74 3509 9 IL-6 IL-6 NNP cord-015021-pol2qm74 3509 10 and and CC cord-015021-pol2qm74 3509 11 IL-8 IL-8 NNP cord-015021-pol2qm74 3509 12 release release NN cord-015021-pol2qm74 3509 13 may may MD cord-015021-pol2qm74 3509 14 be be VB cord-015021-pol2qm74 3509 15 induced induce VBN cord-015021-pol2qm74 3509 16 by by IN cord-015021-pol2qm74 3509 17 cdtical cdtical JJ cord-015021-pol2qm74 3509 18 illness illness NN cord-015021-pol2qm74 3509 19 ; ; : cord-015021-pol2qm74 3509 20 however however RB cord-015021-pol2qm74 3509 21 , , , cord-015021-pol2qm74 3509 22 in in IN cord-015021-pol2qm74 3509 23 subjects subject NNS cord-015021-pol2qm74 3509 24 in in IN cord-015021-pol2qm74 3509 25 which which WDT cord-015021-pol2qm74 3509 26 sepsis sepsis NN cord-015021-pol2qm74 3509 27 occurred occur VBD cord-015021-pol2qm74 3509 28 , , , cord-015021-pol2qm74 3509 29 IL-6 IL-6 NNP cord-015021-pol2qm74 3509 30 and and CC cord-015021-pol2qm74 3509 31 IL-8 IL-8 NNP cord-015021-pol2qm74 3509 32 production production NN cord-015021-pol2qm74 3509 33 appears appear VBZ cord-015021-pol2qm74 3509 34 more more RBR cord-015021-pol2qm74 3509 35 significantly significantly RB cord-015021-pol2qm74 3509 36 elevated elevate VBN cord-015021-pol2qm74 3509 37 , , , cord-015021-pol2qm74 3509 38 suggesting suggest VBG cord-015021-pol2qm74 3509 39 a a DT cord-015021-pol2qm74 3509 40 role role NN cord-015021-pol2qm74 3509 41 of of IN cord-015021-pol2qm74 3509 42 IL-6 IL-6 NNP cord-015021-pol2qm74 3509 43 and and CC cord-015021-pol2qm74 3509 44 11_-8 11_-8 CD cord-015021-pol2qm74 3509 45 in in IN cord-015021-pol2qm74 3509 46 the the DT cord-015021-pol2qm74 3509 47 pathophysiology pathophysiology NN cord-015021-pol2qm74 3509 48 of of IN cord-015021-pol2qm74 3509 49 sepsis sepsis NN cord-015021-pol2qm74 3509 50 . . . cord-015021-pol2qm74 3510 1 The the DT cord-015021-pol2qm74 3510 2 fact fact NN cord-015021-pol2qm74 3510 3 that that IN cord-015021-pol2qm74 3510 4 II II NNP cord-015021-pol2qm74 3510 5 . . . cord-015021-pol2qm74 3511 1 Objective objective NN cord-015021-pol2qm74 3511 2 : : : cord-015021-pol2qm74 3511 3 To to TO cord-015021-pol2qm74 3511 4 check check VB cord-015021-pol2qm74 3511 5 whether whether IN cord-015021-pol2qm74 3511 6 continuous continuous JJ cord-015021-pol2qm74 3511 7 veno veno NNP cord-015021-pol2qm74 3511 8 - - HYPH cord-015021-pol2qm74 3511 9 venous venous JJ cord-015021-pol2qm74 3511 10 haemofiltration haemofiltration NNP cord-015021-pol2qm74 3511 11 ( ( -LRB- cord-015021-pol2qm74 3511 12 CVVH CVVH NNP cord-015021-pol2qm74 3511 13 ) ) -RRB- cord-015021-pol2qm74 3511 14 could could MD cord-015021-pol2qm74 3511 15 remove remove VB cord-015021-pol2qm74 3511 16 the the DT cord-015021-pol2qm74 3511 17 cytokines cytokine NNS cord-015021-pol2qm74 3511 18 , , , cord-015021-pol2qm74 3511 19 namely namely RB cord-015021-pol2qm74 3511 20 tumour tumour NN cord-015021-pol2qm74 3511 21 necrosis necrosis NN cord-015021-pol2qm74 3511 22 factor factor NN cord-015021-pol2qm74 3511 23 alpha alpha NN cord-015021-pol2qm74 3511 24 ( ( -LRB- cord-015021-pol2qm74 3511 25 TNFc TNFc NNP cord-015021-pol2qm74 3511 26 0 0 NFP cord-015021-pol2qm74 3511 27 and and CC cord-015021-pol2qm74 3511 28 interleukin interleukin NN cord-015021-pol2qm74 3511 29 6 6 CD cord-015021-pol2qm74 3511 30 ( ( -LRB- cord-015021-pol2qm74 3511 31 IL-6 IL-6 NNP cord-015021-pol2qm74 3511 32 ) ) -RRB- cord-015021-pol2qm74 3511 33 from from IN cord-015021-pol2qm74 3511 34 the the DT cord-015021-pol2qm74 3511 35 circulation circulation NN cord-015021-pol2qm74 3511 36 of of IN cord-015021-pol2qm74 3511 37 critically critically RB cord-015021-pol2qm74 3511 38 ill ill JJ cord-015021-pol2qm74 3511 39 patients patient NNS cord-015021-pol2qm74 3511 40 with with IN cord-015021-pol2qm74 3511 41 sepsis sepsis NN cord-015021-pol2qm74 3511 42 ad ad NN cord-015021-pol2qm74 3511 43 multiple multiple JJ cord-015021-pol2qm74 3511 44 organ organ NN cord-015021-pol2qm74 3511 45 failure failure NN cord-015021-pol2qm74 3511 46 ( ( -LRB- cord-015021-pol2qm74 3511 47 MOF MOF NNP cord-015021-pol2qm74 3511 48 ) ) -RRB- cord-015021-pol2qm74 3511 49 . . . cord-015021-pol2qm74 3512 1 Setting set VBG cord-015021-pol2qm74 3512 2 : : : cord-015021-pol2qm74 3512 3 The the DT cord-015021-pol2qm74 3512 4 intensive intensive JJ cord-015021-pol2qm74 3512 5 therapy therapy NN cord-015021-pol2qm74 3512 6 unit unit NN cord-015021-pol2qm74 3512 7 of of IN cord-015021-pol2qm74 3512 8 the the DT cord-015021-pol2qm74 3512 9 medical medical JJ cord-015021-pol2qm74 3512 10 school school NN cord-015021-pol2qm74 3512 11 teaching teaching NN cord-015021-pol2qm74 3512 12 hospital hospital NN cord-015021-pol2qm74 3512 13 . . . cord-015021-pol2qm74 3513 1 Patients patient NNS cord-015021-pol2qm74 3513 2 : : : cord-015021-pol2qm74 3514 1 Nine nine CD cord-015021-pol2qm74 3514 2 critically critically RB cord-015021-pol2qm74 3514 3 ill ill JJ cord-015021-pol2qm74 3514 4 patients patient NNS cord-015021-pol2qm74 3514 5 with with IN cord-015021-pol2qm74 3514 6 sepsis sepsis NN cord-015021-pol2qm74 3514 7 and and CC cord-015021-pol2qm74 3514 8 MOF MOF NNP cord-015021-pol2qm74 3514 9 treated treat VBN cord-015021-pol2qm74 3514 10 with with IN cord-015021-pol2qm74 3514 11 CVVH CVVH NNP cord-015021-pol2qm74 3514 12 . . . cord-015021-pol2qm74 3515 1 Methods method NNS cord-015021-pol2qm74 3515 2 : : : cord-015021-pol2qm74 3515 3 Blood blood NN cord-015021-pol2qm74 3515 4 samples sample NNS cord-015021-pol2qm74 3515 5 were be VBD cord-015021-pol2qm74 3515 6 collected collect VBN cord-015021-pol2qm74 3515 7 before before IN cord-015021-pol2qm74 3515 8 the the DT cord-015021-pol2qm74 3515 9 CVVH CVVH NNP cord-015021-pol2qm74 3515 10 had have VBD cord-015021-pol2qm74 3515 11 been be VBN cord-015021-pol2qm74 3515 12 started start VBN cord-015021-pol2qm74 3515 13 . . . cord-015021-pol2qm74 3516 1 Then then RB cord-015021-pol2qm74 3516 2 , , , cord-015021-pol2qm74 3516 3 blood blood NN cord-015021-pol2qm74 3516 4 and and CC cord-015021-pol2qm74 3516 5 Ultrafiltrate Ultrafiltrate NNP cord-015021-pol2qm74 3516 6 samples sample NNS cord-015021-pol2qm74 3516 7 were be VBD cord-015021-pol2qm74 3516 8 collected collect VBN cord-015021-pol2qm74 3516 9 simultaneously simultaneously RB cord-015021-pol2qm74 3516 10 after after IN cord-015021-pol2qm74 3516 11 4 4 CD cord-015021-pol2qm74 3516 12 hours hour NNS cord-015021-pol2qm74 3516 13 and and CC cord-015021-pol2qm74 3516 14 every every DT cord-015021-pol2qm74 3516 15 24 24 CD cord-015021-pol2qm74 3516 16 hour hour NN cord-015021-pol2qm74 3516 17 . . . cord-015021-pol2qm74 3517 1 TNFct TNFct NNP cord-015021-pol2qm74 3517 2 and and CC cord-015021-pol2qm74 3517 3 IL-6 IL-6 NNP cord-015021-pol2qm74 3517 4 levels level NNS cord-015021-pol2qm74 3517 5 were be VBD cord-015021-pol2qm74 3517 6 measured measure VBN cord-015021-pol2qm74 3517 7 using use VBG cord-015021-pol2qm74 3517 8 the the DT cord-015021-pol2qm74 3517 9 bioassays bioassay NNS cord-015021-pol2qm74 3517 10 with with IN cord-015021-pol2qm74 3517 11 cell cell NN cord-015021-pol2qm74 3517 12 lines line NNS cord-015021-pol2qm74 3517 13 WEHI-164 WEHI-164 NNP cord-015021-pol2qm74 3517 14 ci13 ci13 NNP cord-015021-pol2qm74 3517 15 and and CC cord-015021-pol2qm74 3517 16 7TD1 7td1 CD cord-015021-pol2qm74 3517 17 , , , cord-015021-pol2qm74 3517 18 respectively respectively RB cord-015021-pol2qm74 3517 19 . . . cord-015021-pol2qm74 3518 1 Other other JJ cord-015021-pol2qm74 3518 2 data datum NNS cord-015021-pol2qm74 3518 3 were be VBD cord-015021-pol2qm74 3518 4 recorded record VBN cord-015021-pol2qm74 3518 5 from from IN cord-015021-pol2qm74 3518 6 the the DT cord-015021-pol2qm74 3518 7 patient patient NN cord-015021-pol2qm74 3518 8 notes note NNS cord-015021-pol2qm74 3518 9 and and CC cord-015021-pol2qm74 3518 10 intensive intensive JJ cord-015021-pol2qm74 3518 11 therapy therapy NN cord-015021-pol2qm74 3518 12 unit unit NN cord-015021-pol2qm74 3518 13 charts chart NNS cord-015021-pol2qm74 3518 14 . . . cord-015021-pol2qm74 3519 1 Results result NNS cord-015021-pol2qm74 3519 2 : : : cord-015021-pol2qm74 3520 1 No no DT cord-015021-pol2qm74 3520 2 measurable measurable JJ cord-015021-pol2qm74 3520 3 concentrations concentration NNS cord-015021-pol2qm74 3520 4 of of IN cord-015021-pol2qm74 3520 5 TNFct TNFct NNP cord-015021-pol2qm74 3520 6 were be VBD cord-015021-pol2qm74 3520 7 detected detect VBN cord-015021-pol2qm74 3520 8 in in IN cord-015021-pol2qm74 3520 9 either either CC cord-015021-pol2qm74 3520 10 blood blood NN cord-015021-pol2qm74 3520 11 or or CC cord-015021-pol2qm74 3520 12 ultrafiltrate ultrafiltrate JJ cord-015021-pol2qm74 3520 13 samples sample NNS cord-015021-pol2qm74 3520 14 . . . cord-015021-pol2qm74 3521 1 IL-6 IL-6 NNP cord-015021-pol2qm74 3521 2 was be VBD cord-015021-pol2qm74 3521 3 found find VBN cord-015021-pol2qm74 3521 4 in in IN cord-015021-pol2qm74 3521 5 all all PDT cord-015021-pol2qm74 3521 6 the the DT cord-015021-pol2qm74 3521 7 patients patient NNS cord-015021-pol2qm74 3521 8 ' ' POS cord-015021-pol2qm74 3521 9 plasma plasma NN cord-015021-pol2qm74 3521 10 samples sample NNS cord-015021-pol2qm74 3521 11 and and CC cord-015021-pol2qm74 3521 12 five five CD cord-015021-pol2qm74 3521 13 patients patient NNS cord-015021-pol2qm74 3521 14 ' ' '' cord-015021-pol2qm74 3521 15 ( ( -LRB- cord-015021-pol2qm74 3521 16 55.5 55.5 CD cord-015021-pol2qm74 3521 17 % % NN cord-015021-pol2qm74 3521 18 ) ) -RRB- cord-015021-pol2qm74 3521 19 ultrafiltrate ultrafiltrate JJ cord-015021-pol2qm74 3521 20 samples sample NNS cord-015021-pol2qm74 3521 21 . . . cord-015021-pol2qm74 3522 1 The the DT cord-015021-pol2qm74 3522 2 IL-6 IL-6 NNP cord-015021-pol2qm74 3522 3 blood blood NN cord-015021-pol2qm74 3522 4 level level NN cord-015021-pol2qm74 3522 5 ranged range VBD cord-015021-pol2qm74 3522 6 from from IN cord-015021-pol2qm74 3522 7 17.4 17.4 CD cord-015021-pol2qm74 3522 8 to to IN cord-015021-pol2qm74 3522 9 3061.7 3061.7 CD cord-015021-pol2qm74 3522 10 U U NNP cord-015021-pol2qm74 3522 11 / / SYM cord-015021-pol2qm74 3522 12 ml ml XX cord-015021-pol2qm74 3523 1 ( ( -LRB- cord-015021-pol2qm74 3523 2 mean mean VB cord-015021-pol2qm74 3523 3 518.2 518.2 CD cord-015021-pol2qm74 3523 4 , , , cord-015021-pol2qm74 3523 5 SD SD NNP cord-015021-pol2qm74 3523 6 686.8 686.8 CD cord-015021-pol2qm74 3523 7 ) ) -RRB- cord-015021-pol2qm74 3523 8 . . . cord-015021-pol2qm74 3524 1 The the DT cord-015021-pol2qm74 3524 2 IL-6 IL-6 NNP cord-015021-pol2qm74 3524 3 level level NN cord-015021-pol2qm74 3524 4 in in IN cord-015021-pol2qm74 3524 5 positive positive JJ cord-015021-pol2qm74 3524 6 ultrafiltrate ultrafiltrate JJ cord-015021-pol2qm74 3524 7 samples sample NNS cord-015021-pol2qm74 3524 8 ranged range VBD cord-015021-pol2qm74 3524 9 from from IN cord-015021-pol2qm74 3524 10 21.0 21.0 CD cord-015021-pol2qm74 3524 11 to to IN cord-015021-pol2qm74 3524 12 1150.2 1150.2 CD cord-015021-pol2qm74 3524 13 U U NNP cord-015021-pol2qm74 3524 14 / / SYM cord-015021-pol2qm74 3524 15 ml ml XX cord-015021-pol2qm74 3525 1 ( ( -LRB- cord-015021-pol2qm74 3525 2 mean mean VB cord-015021-pol2qm74 3526 1 252.2 252.2 CD cord-015021-pol2qm74 3526 2 , , , cord-015021-pol2qm74 3526 3 SD SD NNP cord-015021-pol2qm74 3526 4 401.8 401.8 CD cord-015021-pol2qm74 3526 5 ) ) -RRB- cord-015021-pol2qm74 3526 6 . . . cord-015021-pol2qm74 3527 1 Conclusions conclusion NNS cord-015021-pol2qm74 3527 2 : : : cord-015021-pol2qm74 3528 1 Our -PRON- PRP$ cord-015021-pol2qm74 3528 2 preliminary preliminary JJ cord-015021-pol2qm74 3528 3 results result NNS cord-015021-pol2qm74 3528 4 suggest suggest VBP cord-015021-pol2qm74 3528 5 that that IN cord-015021-pol2qm74 3528 6 IL-6 IL-6 NNP cord-015021-pol2qm74 3528 7 is be VBZ cord-015021-pol2qm74 3528 8 present present JJ cord-015021-pol2qm74 3528 9 in in IN cord-015021-pol2qm74 3528 10 bloodstream bloodstream NN cord-015021-pol2qm74 3528 11 of of IN cord-015021-pol2qm74 3528 12 septic septic JJ cord-015021-pol2qm74 3528 13 patients patient NNS cord-015021-pol2qm74 3528 14 . . . cord-015021-pol2qm74 3529 1 We -PRON- PRP cord-015021-pol2qm74 3529 2 assume assume VBP cord-015021-pol2qm74 3529 3 we -PRON- PRP cord-015021-pol2qm74 3529 4 coUld coUld MD cord-015021-pol2qm74 3529 5 not not RB cord-015021-pol2qm74 3529 6 detect detect VB cord-015021-pol2qm74 3529 7 TNFa TNFa NNS cord-015021-pol2qm74 3529 8 in in IN cord-015021-pol2qm74 3529 9 any any DT cord-015021-pol2qm74 3529 10 sample sample NN cord-015021-pol2qm74 3529 11 because because IN cord-015021-pol2qm74 3529 12 we -PRON- PRP cord-015021-pol2qm74 3529 13 usually usually RB cord-015021-pol2qm74 3529 14 started start VBD cord-015021-pol2qm74 3529 15 observations observation NNS cord-015021-pol2qm74 3529 16 when when WRB cord-015021-pol2qm74 3529 17 septic septic JJ cord-015021-pol2qm74 3529 18 state state NN cord-015021-pol2qm74 3529 19 had have VBD cord-015021-pol2qm74 3529 20 developed develop VBN cord-015021-pol2qm74 3529 21 . . . cord-015021-pol2qm74 3530 1 CVVH CVVH NNP cord-015021-pol2qm74 3530 2 could could MD cord-015021-pol2qm74 3530 3 extract extract VB cord-015021-pol2qm74 3530 4 cytokines cytokine NNS cord-015021-pol2qm74 3530 5 from from IN cord-015021-pol2qm74 3530 6 the the DT cord-015021-pol2qm74 3530 7 circulating circulate VBG cord-015021-pol2qm74 3530 8 blood blood NN cord-015021-pol2qm74 3530 9 . . . cord-015021-pol2qm74 3531 1 It -PRON- PRP cord-015021-pol2qm74 3531 2 remains remain VBZ cord-015021-pol2qm74 3531 3 under under IN cord-015021-pol2qm74 3531 4 discussion discussion NN cord-015021-pol2qm74 3531 5 , , , cord-015021-pol2qm74 3531 6 whether whether IN cord-015021-pol2qm74 3531 7 that that DT cord-015021-pol2qm74 3531 8 extraction extraction NN cord-015021-pol2qm74 3531 9 may may MD cord-015021-pol2qm74 3531 10 be be VB cord-015021-pol2qm74 3531 11 beneficial beneficial JJ cord-015021-pol2qm74 3531 12 to to IN cord-015021-pol2qm74 3531 13 patients patient NNS cord-015021-pol2qm74 3531 14 with with IN cord-015021-pol2qm74 3531 15 MOF MOF NNP cord-015021-pol2qm74 3531 16 . . . cord-015021-pol2qm74 3532 1 The the DT cord-015021-pol2qm74 3532 2 pattern pattern NN cord-015021-pol2qm74 3532 3 of of IN cord-015021-pol2qm74 3532 4 some some DT cord-015021-pol2qm74 3532 5 significant significant JJ cord-015021-pol2qm74 3532 6 cytokines cytokine NNS cord-015021-pol2qm74 3532 7 TNF TNF NNP cord-015021-pol2qm74 3532 8 , , , cord-015021-pol2qm74 3532 9 IL-1 IL-1 NNP cord-015021-pol2qm74 3532 10 and and CC cord-015021-pol2qm74 3532 11 IL-6 IL-6 NNP cord-015021-pol2qm74 3532 12 and and CC cord-015021-pol2qm74 3532 13 their -PRON- PRP$ cord-015021-pol2qm74 3532 14 pharmacomodulation pharmacomodulation NN cord-015021-pol2qm74 3532 15 were be VBD cord-015021-pol2qm74 3532 16 evaluated evaluate VBN cord-015021-pol2qm74 3532 17 in in IN cord-015021-pol2qm74 3532 18 an an DT cord-015021-pol2qm74 3532 19 experimental experimental JJ cord-015021-pol2qm74 3532 20 model model NN cord-015021-pol2qm74 3532 21 of of IN cord-015021-pol2qm74 3532 22 polimicrobial polimicrobial JJ cord-015021-pol2qm74 3532 23 sepsis sepsis NN cord-015021-pol2qm74 3532 24 induced induce VBN cord-015021-pol2qm74 3532 25 in in IN cord-015021-pol2qm74 3532 26 CD-1 CD-1 NNP cord-015021-pol2qm74 3532 27 mice mouse NNS cord-015021-pol2qm74 3532 28 by by IN cord-015021-pol2qm74 3532 29 cecal cecal JJ cord-015021-pol2qm74 3532 30 ligation ligation NN cord-015021-pol2qm74 3532 31 and and CC cord-015021-pol2qm74 3532 32 puncture puncture NN cord-015021-pol2qm74 3532 33 ( ( -LRB- cord-015021-pol2qm74 3532 34 CLP CLP NNP cord-015021-pol2qm74 3532 35 ) ) -RRB- cord-015021-pol2qm74 3532 36 in in IN cord-015021-pol2qm74 3532 37 order order NN cord-015021-pol2qm74 3532 38 to to TO cord-015021-pol2qm74 3532 39 understand understand VB cord-015021-pol2qm74 3532 40 their -PRON- PRP$ cord-015021-pol2qm74 3532 41 roles role NNS cord-015021-pol2qm74 3532 42 . . . cord-015021-pol2qm74 3533 1 This this DT cord-015021-pol2qm74 3533 2 model model NN cord-015021-pol2qm74 3533 3 of of IN cord-015021-pol2qm74 3533 4 sepsis sepsis NN cord-015021-pol2qm74 3533 5 , , , cord-015021-pol2qm74 3533 6 which which WDT cord-015021-pol2qm74 3533 7 resembles resemble VBZ cord-015021-pol2qm74 3533 8 the the DT cord-015021-pol2qm74 3533 9 clinical clinical JJ cord-015021-pol2qm74 3533 10 situation situation NN cord-015021-pol2qm74 3533 11 of of IN cord-015021-pol2qm74 3533 12 bowel bowel NN cord-015021-pol2qm74 3533 13 perforation perforation NN cord-015021-pol2qm74 3533 14 , , , cord-015021-pol2qm74 3533 15 was be VBD cord-015021-pol2qm74 3533 16 also also RB cord-015021-pol2qm74 3533 17 compared compare VBN cord-015021-pol2qm74 3533 18 with with IN cord-015021-pol2qm74 3533 19 that that DT cord-015021-pol2qm74 3533 20 induced induce VBN cord-015021-pol2qm74 3533 21 by by IN cord-015021-pol2qm74 3533 22 administration administration NN cord-015021-pol2qm74 3533 23 of of IN cord-015021-pol2qm74 3533 24 pure pure JJ cord-015021-pol2qm74 3533 25 endotoxin endotoxin NN cord-015021-pol2qm74 3533 26 ( ( -LRB- cord-015021-pol2qm74 3533 27 LPS LPS NNP cord-015021-pol2qm74 3533 28 ) ) -RRB- cord-015021-pol2qm74 3533 29 . . . cord-015021-pol2qm74 3534 1 TNF TNF NNP cord-015021-pol2qm74 3534 2 was be VBD cord-015021-pol2qm74 3534 3 detectable detectable JJ cord-015021-pol2qm74 3534 4 in in IN cord-015021-pol2qm74 3534 5 serum serum NN cord-015021-pol2qm74 3534 6 and and CC cord-015021-pol2qm74 3534 7 tissues tissue NNS cord-015021-pol2qm74 3534 8 during during IN cord-015021-pol2qm74 3534 9 the the DT cord-015021-pol2qm74 3534 10 first first JJ cord-015021-pol2qm74 3534 11 4h 4h CD cord-015021-pol2qm74 3534 12 with with IN cord-015021-pol2qm74 3534 13 a a DT cord-015021-pol2qm74 3534 14 peak peak NN cord-015021-pol2qm74 3534 15 2h 2h NN cord-015021-pol2qm74 3534 16 after after IN cord-015021-pol2qm74 3534 17 CLP CLP NNP cord-015021-pol2qm74 3534 18 at at IN cord-015021-pol2qm74 3534 19 a a DT cord-015021-pol2qm74 3534 20 significantly significantly RB cord-015021-pol2qm74 3534 21 lower low JJR cord-015021-pol2qm74 3534 22 level level NN cord-015021-pol2qm74 3534 23 than than IN cord-015021-pol2qm74 3534 24 after after IN cord-015021-pol2qm74 3534 25 LPS lp NNS cord-015021-pol2qm74 3534 26 . . . cord-015021-pol2qm74 3535 1 IL-1 IL-1 NNP cord-015021-pol2qm74 3535 2 was be VBD cord-015021-pol2qm74 3535 3 measurable measurable JJ cord-015021-pol2qm74 3535 4 in in IN cord-015021-pol2qm74 3535 5 serum serum NN cord-015021-pol2qm74 3535 6 only only RB cord-015021-pol2qm74 3535 7 after after IN cord-015021-pol2qm74 3535 8 24h 24h NNS cord-015021-pol2qm74 3535 9 , , , cord-015021-pol2qm74 3535 10 significantly significantly RB cord-015021-pol2qm74 3535 11 increased increase VBD cord-015021-pol2qm74 3535 12 in in IN cord-015021-pol2qm74 3535 13 spleen spleen NN cord-015021-pol2qm74 3535 14 and and CC cord-015021-pol2qm74 3535 15 liver liver NN cord-015021-pol2qm74 3535 16 after after IN cord-015021-pol2qm74 3535 17 4 4 CD cord-015021-pol2qm74 3535 18 and and CC cord-015021-pol2qm74 3535 19 8h 8h NNP cord-015021-pol2qm74 3535 20 and and CC cord-015021-pol2qm74 3535 21 in in IN cord-015021-pol2qm74 3535 22 mesenteric mesenteric JJ cord-015021-pol2qm74 3535 23 lymphonodes lymphonode NNS cord-015021-pol2qm74 3535 24 from from IN cord-015021-pol2qm74 3535 25 8 8 CD cord-015021-pol2qm74 3535 26 to to IN cord-015021-pol2qm74 3535 27 24h 24h NNS cord-015021-pol2qm74 3535 28 after after IN cord-015021-pol2qm74 3535 29 CLP CLP NNP cord-015021-pol2qm74 3535 30 compared compare VBN cord-015021-pol2qm74 3535 31 with with IN cord-015021-pol2qm74 3535 32 shammice shammice NN cord-015021-pol2qm74 3535 33 . . . cord-015021-pol2qm74 3536 1 IL-6 IL-6 NNP cord-015021-pol2qm74 3536 2 was be VBD cord-015021-pol2qm74 3536 3 significantly significantly RB cord-015021-pol2qm74 3536 4 increased increase VBN cord-015021-pol2qm74 3536 5 in in IN cord-015021-pol2qm74 3536 6 serum serum NN cord-015021-pol2qm74 3536 7 throughout throughout IN cord-015021-pol2qm74 3536 8 the the DT cord-015021-pol2qm74 3536 9 first first JJ cord-015021-pol2qm74 3536 10 16h 16h NNS cord-015021-pol2qm74 3536 11 after after IN cord-015021-pol2qm74 3536 12 CLP CLP NNP cord-015021-pol2qm74 3536 13 . . . cord-015021-pol2qm74 3537 1 Pretreatment pretreatment NN cord-015021-pol2qm74 3537 2 with with IN cord-015021-pol2qm74 3537 3 dexamethasone dexamethasone NN cord-015021-pol2qm74 3537 4 ( ( -LRB- cord-015021-pol2qm74 3537 5 DEX DEX NNP cord-015021-pol2qm74 3537 6 ) ) -RRB- cord-015021-pol2qm74 3537 7 , , , cord-015021-pol2qm74 3537 8 ibuprofen ibuprofen NN cord-015021-pol2qm74 3537 9 ( ( -LRB- cord-015021-pol2qm74 3537 10 IBU IBU NNP cord-015021-pol2qm74 3537 11 ) ) -RRB- cord-015021-pol2qm74 3537 12 and and CC cord-015021-pol2qm74 3537 13 nitro nitro NN cord-015021-pol2qm74 3537 14 - - HYPH cord-015021-pol2qm74 3537 15 L l NN cord-015021-pol2qm74 3537 16 - - HYPH cord-015021-pol2qm74 3537 17 arginine arginine NN cord-015021-pol2qm74 3537 18 ( ( -LRB- cord-015021-pol2qm74 3537 19 N N NNP cord-015021-pol2qm74 3537 20 - - HYPH cord-015021-pol2qm74 3537 21 ARG ARG NNP cord-015021-pol2qm74 3537 22 ) ) -RRB- cord-015021-pol2qm74 3537 23 significantly significantly RB cord-015021-pol2qm74 3537 24 reduced reduce VBD cord-015021-pol2qm74 3537 25 the the DT cord-015021-pol2qm74 3537 26 survival survival NN cord-015021-pol2qm74 3537 27 time time NN cord-015021-pol2qm74 3537 28 while while IN cord-015021-pol2qm74 3537 29 chlorpromazine chlorpromazine NN cord-015021-pol2qm74 3537 30 ( ( -LRB- cord-015021-pol2qm74 3537 31 CPZ CPZ NNP cord-015021-pol2qm74 3537 32 ) ) -RRB- cord-015021-pol2qm74 3537 33 and and CC cord-015021-pol2qm74 3537 34 TNF TNF NNP cord-015021-pol2qm74 3537 35 did do VBD cord-015021-pol2qm74 3537 36 not not RB cord-015021-pol2qm74 3537 37 affect affect VB cord-015021-pol2qm74 3537 38 it -PRON- PRP cord-015021-pol2qm74 3537 39 . . . cord-015021-pol2qm74 3538 1 Only only RB cord-015021-pol2qm74 3538 2 the the DT cord-015021-pol2qm74 3538 3 antibiotics antibiotic NNS cord-015021-pol2qm74 3538 4 and and CC cord-015021-pol2qm74 3538 5 pentoxifylline pentoxifylline NNP cord-015021-pol2qm74 3538 6 ( ( -LRB- cord-015021-pol2qm74 3538 7 PTX PTX NNP cord-015021-pol2qm74 3538 8 ) ) -RRB- cord-015021-pol2qm74 3538 9 significantly significantly RB cord-015021-pol2qm74 3538 10 increased increase VBD cord-015021-pol2qm74 3538 11 the the DT cord-015021-pol2qm74 3538 12 survival survival NN cord-015021-pol2qm74 3538 13 in in IN cord-015021-pol2qm74 3538 14 CLP CLP NNP cord-015021-pol2qm74 3538 15 . . . cord-015021-pol2qm74 3539 1 However however RB cord-015021-pol2qm74 3539 2 CPZ CPZ NNP cord-015021-pol2qm74 3539 3 and and CC cord-015021-pol2qm74 3539 4 DEX DEX NNP cord-015021-pol2qm74 3539 5 protected protect VBN cord-015021-pol2qm74 3539 6 from from IN cord-015021-pol2qm74 3539 7 LPS LPS NNP cord-015021-pol2qm74 3539 8 - - HYPH cord-015021-pol2qm74 3539 9 mor mor NNP cord-015021-pol2qm74 3539 10 ~ ~ NFP cord-015021-pol2qm74 3539 11 ality ality NN cord-015021-pol2qm74 3539 12 . . . cord-015021-pol2qm74 3540 1 In in IN cord-015021-pol2qm74 3540 2 conclusion conclusion NN cord-015021-pol2qm74 3540 3 , , , cord-015021-pol2qm74 3540 4 by by IN cord-015021-pol2qm74 3540 5 inhibiting inhibit VBG cord-015021-pol2qm74 3540 6 TNF TNF NNP cord-015021-pol2qm74 3540 7 with with IN cord-015021-pol2qm74 3540 8 DEX DEX NNP cord-015021-pol2qm74 3540 9 , , , cord-015021-pol2qm74 3540 10 CPZ CPZ NNP cord-015021-pol2qm74 3540 11 , , , cord-015021-pol2qm74 3540 12 PTX PTX NNP cord-015021-pol2qm74 3540 13 a a DT cord-015021-pol2qm74 3540 14 reduced reduce VBN cord-015021-pol2qm74 3540 15 , , , cord-015021-pol2qm74 3540 16 unchanged unchanged JJ cord-015021-pol2qm74 3540 17 and and CC cord-015021-pol2qm74 3540 18 increased increased JJ cord-015021-pol2qm74 3540 19 survival survival NN cord-015021-pol2qm74 3540 20 time time NN cord-015021-pol2qm74 3540 21 was be VBD cord-015021-pol2qm74 3540 22 observed observe VBN cord-015021-pol2qm74 3540 23 and and CC cord-015021-pol2qm74 3540 24 by by IN cord-015021-pol2qm74 3540 25 increasing increase VBG cord-015021-pol2qm74 3540 26 TNF TNF NNP cord-015021-pol2qm74 3540 27 with with IN cord-015021-pol2qm74 3540 28 IBU IBU NNP cord-015021-pol2qm74 3540 29 and and CC cord-015021-pol2qm74 3540 30 TNF TNF NNP cord-015021-pol2qm74 3540 31 administration administration NN cord-015021-pol2qm74 3540 32 the the DT cord-015021-pol2qm74 3540 33 survival survival NN cord-015021-pol2qm74 3540 34 was be VBD cord-015021-pol2qm74 3540 35 decreased decrease VBN cord-015021-pol2qm74 3540 36 or or CC cord-015021-pol2qm74 3540 37 unchanged unchanged JJ cord-015021-pol2qm74 3540 38 respectively respectively RB cord-015021-pol2qm74 3540 39 suggesting suggest VBG cord-015021-pol2qm74 3540 40 that that IN cord-015021-pol2qm74 3540 41 the the DT cord-015021-pol2qm74 3540 42 modulation modulation NN cord-015021-pol2qm74 3540 43 of of IN cord-015021-pol2qm74 3540 44 this this DT cord-015021-pol2qm74 3540 45 cytokine cytokine NN cord-015021-pol2qm74 3540 46 does do VBZ cord-015021-pol2qm74 3540 47 not not RB cord-015021-pol2qm74 3540 48 seem seem VB cord-015021-pol2qm74 3540 49 to to TO cord-015021-pol2qm74 3540 50 play play VB cord-015021-pol2qm74 3540 51 a a DT cord-015021-pol2qm74 3540 52 significant significant JJ cord-015021-pol2qm74 3540 53 role role NN cord-015021-pol2qm74 3540 54 in in IN cord-015021-pol2qm74 3540 55 CLP CLP NNP cord-015021-pol2qm74 3540 56 unlike unlike IN cord-015021-pol2qm74 3540 57 LPS lp NNS cord-015021-pol2qm74 3541 1 _ _ NNP cord-015021-pol2qm74 3541 2 Moreover moreover RB cord-015021-pol2qm74 3541 3 the the DT cord-015021-pol2qm74 3541 4 negative negative JJ cord-015021-pol2qm74 3541 5 effects effect NNS cord-015021-pol2qm74 3541 6 of of IN cord-015021-pol2qm74 3541 7 IBU IBU NNP cord-015021-pol2qm74 3541 8 and and CC cord-015021-pol2qm74 3541 9 N N NNP cord-015021-pol2qm74 3541 10 - - HYPH cord-015021-pol2qm74 3541 11 ARG ARG NNP cord-015021-pol2qm74 3541 12 suggest suggest VBP cord-015021-pol2qm74 3541 13 an an DT cord-015021-pol2qm74 3541 14 important important JJ cord-015021-pol2qm74 3541 15 and and CC cord-015021-pol2qm74 3541 16 protective protective JJ cord-015021-pol2qm74 3541 17 role role NN cord-015021-pol2qm74 3541 18 by by IN cord-015021-pol2qm74 3541 19 prostaglandins prostaglandin NNS cord-015021-pol2qm74 3541 20 and and CC cord-015021-pol2qm74 3541 21 NO no RB cord-015021-pol2qm74 3541 22 in in IN cord-015021-pol2qm74 3541 23 CLP CLP NNP cord-015021-pol2qm74 3541 24 . . . cord-015021-pol2qm74 3542 1 To to TO cord-015021-pol2qm74 3542 2 gain gain VB cord-015021-pol2qm74 3542 3 more more JJR cord-015021-pol2qm74 3542 4 insigths insigth NNS cord-015021-pol2qm74 3542 5 on on IN cord-015021-pol2qm74 3542 6 the the DT cord-015021-pol2qm74 3542 7 contribution contribution NN cord-015021-pol2qm74 3542 8 of of IN cord-015021-pol2qm74 3542 9 TNF~ TNF~ NNP cord-015021-pol2qm74 3542 10 , , , cord-015021-pol2qm74 3542 11 IL IL NNP cord-015021-pol2qm74 3542 12 - - HYPH cord-015021-pol2qm74 3542 13 I~ I~ NNP cord-015021-pol2qm74 3542 14 and and CC cord-015021-pol2qm74 3542 15 IF if IN cord-015021-pol2qm74 3542 16 7 7 CD cord-015021-pol2qm74 3542 17 to to IN cord-015021-pol2qm74 3542 18 LPS LPS NNP cord-015021-pol2qm74 3542 19 toxicity toxicity NN cord-015021-pol2qm74 3542 20 , , , cord-015021-pol2qm74 3542 21 we -PRON- PRP cord-015021-pol2qm74 3542 22 explored explore VBD cord-015021-pol2qm74 3542 23 the the DT cord-015021-pol2qm74 3542 24 time time NN cord-015021-pol2qm74 3542 25 - - HYPH cord-015021-pol2qm74 3542 26 course course NN cord-015021-pol2qm74 3542 27 of of IN cord-015021-pol2qm74 3542 28 the the DT cord-015021-pol2qm74 3542 29 cytokine cytokine NN cord-015021-pol2qm74 3542 30 production production NN cord-015021-pol2qm74 3542 31 in in IN cord-015021-pol2qm74 3542 32 Ealb Ealb NNP cord-015021-pol2qm74 3542 33 / / SYM cord-015021-pol2qm74 3542 34 C c NN cord-015021-pol2qm74 3542 35 mice mouse NNS cord-015021-pol2qm74 3542 36 given give VBN cord-015021-pol2qm74 3542 37 different different JJ cord-015021-pol2qm74 3542 38 doses dose NNS cord-015021-pol2qm74 3542 39 , , , cord-015021-pol2qm74 3542 40 from from IN cord-015021-pol2qm74 3542 41 the the DT cord-015021-pol2qm74 3542 42 lethal lethal JJ cord-015021-pol2qm74 3542 43 (= (= NNP cord-015021-pol2qm74 3542 44 3 3 CD cord-015021-pol2qm74 3542 45 LD50 LD50 NNP cord-015021-pol2qm74 3542 46 ) ) -RRB- cord-015021-pol2qm74 3542 47 to to IN cord-015021-pol2qm74 3542 48 the the DT cord-015021-pol2qm74 3542 49 sublethal sublethal NN cord-015021-pol2qm74 3542 50 (= (= NNP cord-015021-pol2qm74 3542 51 1/3 1/3 CD cord-015021-pol2qm74 3542 52 LD50 LD50 NNP cord-015021-pol2qm74 3542 53 ) ) -RRB- cord-015021-pol2qm74 3542 54 of of IN cord-015021-pol2qm74 3542 55 three three CD cord-015021-pol2qm74 3542 56 different different JJ cord-015021-pol2qm74 3542 57 LPS lp NNS cord-015021-pol2qm74 3543 1 ( ( -LRB- cord-015021-pol2qm74 3543 2 E.coli E.coli NNS cord-015021-pol2qm74 3543 3 OIII OIII NNP cord-015021-pol2qm74 3543 4 : : : cord-015021-pol2qm74 3543 5 B4 B4 NNP cord-015021-pol2qm74 3543 6 and and CC cord-015021-pol2qm74 3543 7 026 026 CD cord-015021-pol2qm74 3543 8 : : : cord-015021-pol2qm74 3543 9 B6 b6 NN cord-015021-pol2qm74 3543 10 ; ; : cord-015021-pol2qm74 3543 11 P.aeruginosa P.aeruginosa NNP cord-015021-pol2qm74 3543 12 R261 R261 NNPS cord-015021-pol2qm74 3543 13 ) ) -RRB- cord-015021-pol2qm74 3543 14 endowed endow VBN cord-015021-pol2qm74 3543 15 with with IN cord-015021-pol2qm74 3543 16 different different JJ cord-015021-pol2qm74 3543 17 degree degree NN cord-015021-pol2qm74 3543 18 of of IN cord-015021-pol2qm74 3543 19 toxicity toxicity NN cord-015021-pol2qm74 3543 20 Cytokines Cytokines NNPS cord-015021-pol2qm74 3543 21 were be VBD cord-015021-pol2qm74 3543 22 measured measure VBN cord-015021-pol2qm74 3543 23 in in IN cord-015021-pol2qm74 3543 24 serum serum NN cord-015021-pol2qm74 3543 25 and and CC cord-015021-pol2qm74 3543 26 organs organ NNS cord-015021-pol2qm74 3543 27 with with IN cord-015021-pol2qm74 3543 28 specific specific JJ cord-015021-pol2qm74 3543 29 ELISAs elisa NNS cord-015021-pol2qm74 3543 30 up up RP cord-015021-pol2qm74 3543 31 to to IN cord-015021-pol2qm74 3543 32 I0 I0 NNP cord-015021-pol2qm74 3543 33 h h NN cord-015021-pol2qm74 3543 34 after after IN cord-015021-pol2qm74 3543 35 LPS LPS NNP cord-015021-pol2qm74 3543 36 administration administration NN cord-015021-pol2qm74 3543 37 . . . cord-015021-pol2qm74 3544 1 Results result NNS cord-015021-pol2qm74 3544 2 demonstrate demonstrate VBP cord-015021-pol2qm74 3544 3 that that IN cord-015021-pol2qm74 3544 4 i i PRP cord-015021-pol2qm74 3544 5 ) ) -RRB- cord-015021-pol2qm74 3544 6 circulating circulate VBG cord-015021-pol2qm74 3544 7 and and CC cord-015021-pol2qm74 3544 8 organ organ NN cord-015021-pol2qm74 3544 9 levels level NNS cord-015021-pol2qm74 3544 10 of of IN cord-015021-pol2qm74 3544 11 TNF~ TNF~ NNS cord-015021-pol2qm74 3544 12 do do VBP cord-015021-pol2qm74 3544 13 not not RB cord-015021-pol2qm74 3544 14 reflect reflect VB cord-015021-pol2qm74 3544 15 LPS LPS NNP cord-015021-pol2qm74 3544 16 toxicity toxicity NN cord-015021-pol2qm74 3544 17 . . . cord-015021-pol2qm74 3545 1 In in IN cord-015021-pol2qm74 3545 2 fact fact NN cord-015021-pol2qm74 3545 3 , , , cord-015021-pol2qm74 3545 4 the the DT cord-015021-pol2qm74 3545 5 lethal lethal JJ cord-015021-pol2qm74 3545 6 dose dose NN cord-015021-pol2qm74 3545 7 of of IN cord-015021-pol2qm74 3545 8 LPS LPS NNP cord-015021-pol2qm74 3545 9 026 026 NN cord-015021-pol2qm74 3545 10 : : : cord-015021-pol2qm74 3545 11 B6 b6 NN cord-015021-pol2qm74 3545 12 induced induce VBN cord-015021-pol2qm74 3545 13 as as RB cord-015021-pol2qm74 3545 14 much much RB cord-015021-pol2qm74 3545 15 TNF~ tnf~ CD cord-015021-pol2qm74 3545 16 as as IN cord-015021-pol2qm74 3545 17 the the DT cord-015021-pol2qm74 3545 18 sublethal sublethal NN cord-015021-pol2qm74 3545 19 dose dose NN cord-015021-pol2qm74 3545 20 of of IN cord-015021-pol2qm74 3545 21 LPS LPS NNP cord-015021-pol2qm74 3545 22 0111 0111 CD cord-015021-pol2qm74 3545 23 : : : cord-015021-pol2qm74 3545 24 B4 B4 NNP cord-015021-pol2qm74 3545 25 ; ; : cord-015021-pol2qm74 3545 26 furthermore furthermore RB cord-015021-pol2qm74 3545 27 , , , cord-015021-pol2qm74 3545 28 LPS LPS NNP cord-015021-pol2qm74 3545 29 R261 R261 NNPS cord-015021-pol2qm74 3545 30 , , , cord-015021-pol2qm74 3545 31 whose whose WP$ cord-015021-pol2qm74 3545 32 cytokine cytokine NN cord-015021-pol2qm74 3545 33 inducing induce VBG cord-015021-pol2qm74 3545 34 capability capability NN cord-015021-pol2qm74 3545 35 is be VBZ cord-015021-pol2qm74 3545 36 far far RB cord-015021-pol2qm74 3545 37 lower low JJR cord-015021-pol2qm74 3545 38 than than IN cord-015021-pol2qm74 3545 39 that that DT cord-015021-pol2qm74 3545 40 of of IN cord-015021-pol2qm74 3545 41 LPS LPS NNP cord-015021-pol2qm74 3545 42 from from IN cord-015021-pol2qm74 3545 43 E.coli E.coli NNS cord-015021-pol2qm74 3545 44 , , , cord-015021-pol2qm74 3545 45 induced induce VBN cord-015021-pol2qm74 3545 46 higher high JJR cord-015021-pol2qm74 3545 47 TNF~ tnf~ CD cord-015021-pol2qm74 3545 48 levels level NNS cord-015021-pol2qm74 3545 49 at at IN cord-015021-pol2qm74 3545 50 the the DT cord-015021-pol2qm74 3545 51 sublethal sublethal NN cord-015021-pol2qm74 3545 52 than than IN cord-015021-pol2qm74 3545 53 at at IN cord-015021-pol2qm74 3545 54 the the DT cord-015021-pol2qm74 3545 55 lethal lethal JJ cord-015021-pol2qm74 3545 56 dose dose NN cord-015021-pol2qm74 3545 57 . . . cord-015021-pol2qm74 3546 1 In in IN cord-015021-pol2qm74 3546 2 addition addition NN cord-015021-pol2qm74 3546 3 , , , cord-015021-pol2qm74 3546 4 policlonal policlonal NNP cord-015021-pol2qm74 3546 5 anti anti NNP cord-015021-pol2qm74 3546 6 TNF TNF NNP cord-015021-pol2qm74 3546 7 Ab Ab NNP cord-015021-pol2qm74 3546 8 , , , cord-015021-pol2qm74 3546 9 that that WDT cord-015021-pol2qm74 3546 10 were be VBD cord-015021-pol2qm74 3546 11 able able JJ cord-015021-pol2qm74 3546 12 to to TO cord-015021-pol2qm74 3546 13 protect protect VB cord-015021-pol2qm74 3546 14 mice mouse NNS cord-015021-pol2qm74 3546 15 from from IN cord-015021-pol2qm74 3546 16 E.coli e.coli JJ cord-015021-pol2qm74 3546 17 LPS LPS NNP cord-015021-pol2qm74 3546 18 induced induce VBN cord-015021-pol2qm74 3546 19 mortality mortality NN cord-015021-pol2qm74 3546 20 , , , cord-015021-pol2qm74 3546 21 failed fail VBD cord-015021-pol2qm74 3546 22 in in IN cord-015021-pol2qm74 3546 23 mice mouse NNS cord-015021-pol2qm74 3546 24 treated treat VBN cord-015021-pol2qm74 3546 25 with with IN cord-015021-pol2qm74 3546 26 LPS LPS NNP cord-015021-pol2qm74 3546 27 R261 R261 NNS cord-015021-pol2qm74 3546 28 2 2 CD cord-015021-pol2qm74 3546 29 ) ) -RRB- cord-015021-pol2qm74 3547 1 Circulating circulate VBG cord-015021-pol2qm74 3547 2 IL IL NNP cord-015021-pol2qm74 3547 3 - - HYPH cord-015021-pol2qm74 3547 4 I~ I~ NNP cord-015021-pol2qm74 3547 5 levels level NNS cord-015021-pol2qm74 3547 6 are be VBP cord-015021-pol2qm74 3547 7 generally generally RB cord-015021-pol2qm74 3547 8 low low JJ cord-015021-pol2qm74 3547 9 and and CC cord-015021-pol2qm74 3547 10 increase increase VBP cord-015021-pol2qm74 3547 11 significantly significantly RB cord-015021-pol2qm74 3547 12 only only RB cord-015021-pol2qm74 3547 13 in in IN cord-015021-pol2qm74 3547 14 muribond muribond NN cord-015021-pol2qm74 3547 15 animals animal NNS cord-015021-pol2qm74 3547 16 . . . cord-015021-pol2qm74 3548 1 On on IN cord-015021-pol2qm74 3548 2 the the DT cord-015021-pol2qm74 3548 3 contrary contrary NN cord-015021-pol2qm74 3548 4 , , , cord-015021-pol2qm74 3548 5 in in IN cord-015021-pol2qm74 3548 6 spleen spleen NN cord-015021-pol2qm74 3548 7 and and CC cord-015021-pol2qm74 3548 8 lung lung NN cord-015021-pol2qm74 3548 9 very very RB cord-015021-pol2qm74 3548 10 high high JJ cord-015021-pol2qm74 3548 11 levels level NNS cord-015021-pol2qm74 3548 12 of of IN cord-015021-pol2qm74 3548 13 IL IL NNP cord-015021-pol2qm74 3548 14 - - HYPH cord-015021-pol2qm74 3548 15 I~ I~ NNP cord-015021-pol2qm74 3548 16 are be VBP cord-015021-pol2qm74 3548 17 persistent persistent JJ cord-015021-pol2qm74 3548 18 from from IN cord-015021-pol2qm74 3548 19 I -PRON- PRP cord-015021-pol2qm74 3548 20 to to IN cord-015021-pol2qm74 3548 21 8 8 CD cord-015021-pol2qm74 3548 22 h h NN cord-015021-pol2qm74 3548 23 post post NN cord-015021-pol2qm74 3548 24 LPS LPS NNP cord-015021-pol2qm74 3548 25 administration administration NN cord-015021-pol2qm74 3549 1 Moreover moreover RB cord-015021-pol2qm74 3549 2 , , , cord-015021-pol2qm74 3549 3 the the DT cord-015021-pol2qm74 3549 4 treatment treatment NN cord-015021-pol2qm74 3549 5 with with IN cord-015021-pol2qm74 3549 6 6 6 CD cord-015021-pol2qm74 3549 7 mgr mgr NN cord-015021-pol2qm74 3549 8 of of IN cord-015021-pol2qm74 3549 9 neutralizing neutralize VBG cord-015021-pol2qm74 3549 10 policlonal policlonal NNP cord-015021-pol2qm74 3549 11 anti anti FW cord-015021-pol2qm74 3549 12 IL IL NNP cord-015021-pol2qm74 3549 13 - - HYPH cord-015021-pol2qm74 3549 14 I~ I~ NNP cord-015021-pol2qm74 3549 15 Ab Ab NNP cord-015021-pol2qm74 3549 16 , , , cord-015021-pol2qm74 3549 17 did do VBD cord-015021-pol2qm74 3549 18 not not RB cord-015021-pol2qm74 3549 19 modify modify VB cord-015021-pol2qm74 3549 20 survival survival NN cord-015021-pol2qm74 3549 21 in in IN cord-015021-pol2qm74 3549 22 LPS lp NNS cord-015021-pol2qm74 3549 23 challenged challenge VBD cord-015021-pol2qm74 3549 24 mice mouse NNS cord-015021-pol2qm74 3549 25 . . . cord-015021-pol2qm74 3550 1 3 3 LS cord-015021-pol2qm74 3550 2 ) ) -RRB- cord-015021-pol2qm74 3551 1 Circulating circulate VBG cord-015021-pol2qm74 3551 2 and and CC cord-015021-pol2qm74 3551 3 organ organ NN cord-015021-pol2qm74 3551 4 levels level NNS cord-015021-pol2qm74 3551 5 of of IN cord-015021-pol2qm74 3551 6 IF if NN cord-015021-pol2qm74 3551 7 7 7 CD cord-015021-pol2qm74 3551 8 are be VBP cord-015021-pol2qm74 3551 9 proportional proportional JJ cord-015021-pol2qm74 3551 10 to to IN cord-015021-pol2qm74 3551 11 the the DT cord-015021-pol2qm74 3551 12 dose dose NN cord-015021-pol2qm74 3551 13 and and CC cord-015021-pol2qm74 3551 14 degree degree NN cord-015021-pol2qm74 3551 15 of of IN cord-015021-pol2qm74 3551 16 toxicity toxicity NN cord-015021-pol2qm74 3551 17 of of IN cord-015021-pol2qm74 3551 18 all all PDT cord-015021-pol2qm74 3551 19 the the DT cord-015021-pol2qm74 3551 20 administered administer VBN cord-015021-pol2qm74 3551 21 LPS LPS NNP cord-015021-pol2qm74 3551 22 even even RB cord-015021-pol2qm74 3551 23 if if IN cord-015021-pol2qm74 3551 24 LPS LPS NNP cord-015021-pol2qm74 3551 25 R261 R261 NNPS cord-015021-pol2qm74 3551 26 was be VBD cord-015021-pol2qm74 3551 27 again again RB cord-015021-pol2qm74 3551 28 a a DT cord-015021-pol2qm74 3551 29 less less RBR cord-015021-pol2qm74 3551 30 efficient efficient JJ cord-015021-pol2qm74 3551 31 cytokine cytokine NN cord-015021-pol2qm74 3551 32 inducer inducer NN cord-015021-pol2qm74 3551 33 than than IN cord-015021-pol2qm74 3551 34 LPS LPS NNP cord-015021-pol2qm74 3551 35 from from IN cord-015021-pol2qm74 3551 36 E.coli E.coli NNS cord-015021-pol2qm74 3551 37 . . . cord-015021-pol2qm74 3552 1 CsA CsA NNP cord-015021-pol2qm74 3552 2 is be VBZ cord-015021-pol2qm74 3552 3 an an DT cord-015021-pol2qm74 3552 4 immunos immunos JJ cord-015021-pol2qm74 3552 5 ~ ~ CD cord-015021-pol2qm74 3552 6 ppressive ppressive NNP cord-015021-pol2qm74 3552 7 drug drug NN cord-015021-pol2qm74 3552 8 , , , cord-015021-pol2qm74 3552 9 able able JJ cord-015021-pol2qm74 3552 10 to to TO cord-015021-pol2qm74 3552 11 inhibit inhibit VB cord-015021-pol2qm74 3552 12 gene gene NN cord-015021-pol2qm74 3552 13 expression expression NN cord-015021-pol2qm74 3552 14 for for IN cord-015021-pol2qm74 3552 15 many many JJ cord-015021-pol2qm74 3552 16 cytokines cytokine NNS cord-015021-pol2qm74 3552 17 , , , cord-015021-pol2qm74 3552 18 including include VBG cord-015021-pol2qm74 3552 19 IF if IN cord-015021-pol2qm74 3552 20 7 7 CD cord-015021-pol2qm74 3552 21 . . . cord-015021-pol2qm74 3553 1 To to TO cord-015021-pol2qm74 3553 2 study study VB cord-015021-pol2qm74 3553 3 the the DT cord-015021-pol2qm74 3553 4 effect effect NN cord-015021-pol2qm74 3553 5 of of IN cord-015021-pol2qm74 3553 6 cytokines cytokine NNS cord-015021-pol2qm74 3553 7 modulation modulation NN cord-015021-pol2qm74 3553 8 on on IN cord-015021-pol2qm74 3553 9 LPS LPS NNP cord-015021-pol2qm74 3553 10 toxicity toxicity NN cord-015021-pol2qm74 3553 11 , , , cord-015021-pol2qm74 3553 12 CsA CsA NNP cord-015021-pol2qm74 3553 13 was be VBD cord-015021-pol2qm74 3553 14 administered administer VBN cord-015021-pol2qm74 3553 15 to to IN cord-015021-pol2qm74 3553 16 mice mouse NNS cord-015021-pol2qm74 3553 17 twice twice RB cord-015021-pol2qm74 3553 18 at at IN cord-015021-pol2qm74 3553 19 the the DT cord-015021-pol2qm74 3553 20 oral oral JJ cord-015021-pol2qm74 3553 21 dose dose NN cord-015021-pol2qm74 3553 22 of of IN cord-015021-pol2qm74 3553 23 i00 i00 NNP cord-015021-pol2qm74 3553 24 mg mg NNP cord-015021-pol2qm74 3553 25 / / SYM cord-015021-pol2qm74 3553 26 kg kg NNS cord-015021-pol2qm74 3553 27 before before IN cord-015021-pol2qm74 3553 28 the the DT cord-015021-pol2qm74 3553 29 challenge challenge NN cord-015021-pol2qm74 3553 30 with with IN cord-015021-pol2qm74 3553 31 LPS LPS NNP cord-015021-pol2qm74 3553 32 . . . cord-015021-pol2qm74 3554 1 Mice mouse NNS cord-015021-pol2qm74 3554 2 were be VBD cord-015021-pol2qm74 3554 3 monitored monitor VBN cord-015021-pol2qm74 3554 4 in in IN cord-015021-pol2qm74 3554 5 terms term NNS cord-015021-pol2qm74 3554 6 of of IN cord-015021-pol2qm74 3554 7 mortality mortality NN cord-015021-pol2qm74 3554 8 and and CC cord-015021-pol2qm74 3554 9 TNF~ TNF~ NNP cord-015021-pol2qm74 3554 10 , , , cord-015021-pol2qm74 3554 11 IL IL NNP cord-015021-pol2qm74 3554 12 - - HYPH cord-015021-pol2qm74 3554 13 I~ I~ NNP cord-015021-pol2qm74 3554 14 and and CC cord-015021-pol2qm74 3554 15 IF if IN cord-015021-pol2qm74 3554 16 7 7 CD cord-015021-pol2qm74 3554 17 production production NN cord-015021-pol2qm74 3554 18 . . . cord-015021-pol2qm74 3555 1 Together together RB cord-015021-pol2qm74 3555 2 with with IN cord-015021-pol2qm74 3555 3 the the DT cord-015021-pol2qm74 3555 4 total total JJ cord-015021-pol2qm74 3555 5 ablation ablation NN cord-015021-pol2qm74 3555 6 of of IN cord-015021-pol2qm74 3555 7 IF7 if7 NN cord-015021-pol2qm74 3555 8 , , , cord-015021-pol2qm74 3555 9 the the DT cord-015021-pol2qm74 3555 10 strong strong JJ cord-015021-pol2qm74 3555 11 reduction reduction NN cord-015021-pol2qm74 3555 12 of of IN cord-015021-pol2qm74 3555 13 TNFu TNFu NNS cord-015021-pol2qm74 3555 14 and and CC cord-015021-pol2qm74 3555 15 unmodified unmodified JJ cord-015021-pol2qm74 3555 16 IL IL NNP cord-015021-pol2qm74 3555 17 - - HYPH cord-015021-pol2qm74 3555 18 I~ I~ NNP cord-015021-pol2qm74 3555 19 levels level NNS cord-015021-pol2qm74 3555 20 , , , cord-015021-pol2qm74 3555 21 a a DT cord-015021-pol2qm74 3555 22 significant significant JJ cord-015021-pol2qm74 3555 23 increase increase NN cord-015021-pol2qm74 3555 24 of of IN cord-015021-pol2qm74 3555 25 LPS LPS NNP cord-015021-pol2qm74 3555 26 toxicity toxicity NN cord-015021-pol2qm74 3555 27 was be VBD cord-015021-pol2qm74 3555 28 also also RB cord-015021-pol2qm74 3555 29 observed observe VBN cord-015021-pol2qm74 3555 30 . . . cord-015021-pol2qm74 3556 1 These these DT cord-015021-pol2qm74 3556 2 results result NNS cord-015021-pol2qm74 3556 3 suggest suggest VBP cord-015021-pol2qm74 3556 4 the the DT cord-015021-pol2qm74 3556 5 hypothesis hypothesis NN cord-015021-pol2qm74 3556 6 that that IN cord-015021-pol2qm74 3556 7 the the DT cord-015021-pol2qm74 3556 8 numerous numerous JJ cord-015021-pol2qm74 3556 9 factors factor NNS cord-015021-pol2qm74 3556 10 that that WDT cord-015021-pol2qm74 3556 11 jointly jointly RB cord-015021-pol2qm74 3556 12 mediate mediate VB cord-015021-pol2qm74 3556 13 LPS LPS NNP cord-015021-pol2qm74 3556 14 toxic toxic JJ cord-015021-pol2qm74 3556 15 effects effect NNS cord-015021-pol2qm74 3556 16 , , , cord-015021-pol2qm74 3556 17 can can MD cord-015021-pol2qm74 3556 18 also also RB cord-015021-pol2qm74 3556 19 be be VB cord-015021-pol2qm74 3556 20 protective protective JJ cord-015021-pol2qm74 3556 21 , , , cord-015021-pol2qm74 3556 22 the the DT cord-015021-pol2qm74 3556 23 final final JJ cord-015021-pol2qm74 3556 24 outcome outcome NN cord-015021-pol2qm74 3556 25 depending depend VBG cord-015021-pol2qm74 3556 26 on on IN cord-015021-pol2qm74 3556 27 their -PRON- PRP$ cord-015021-pol2qm74 3556 28 relative relative JJ cord-015021-pol2qm74 3556 29 ratio ratio NN cord-015021-pol2qm74 3556 30 rather rather RB cord-015021-pol2qm74 3556 31 than than IN cord-015021-pol2qm74 3556 32 on on IN cord-015021-pol2qm74 3556 33 the the DT cord-015021-pol2qm74 3556 34 absolute absolute JJ cord-015021-pol2qm74 3556 35 amount amount NN cord-015021-pol2qm74 3557 1 Interleukin-1 Interleukin-1 NNP cord-015021-pol2qm74 3557 2 ( ( -LRB- cord-015021-pol2qm74 3557 3 IL-1 IL-1 NNP cord-015021-pol2qm74 3557 4 ) ) -RRB- cord-015021-pol2qm74 3557 5 mediates mediate VBZ cord-015021-pol2qm74 3557 6 the the DT cord-015021-pol2qm74 3557 7 septic septic JJ cord-015021-pol2qm74 3557 8 shock shock NN cord-015021-pol2qm74 3557 9 syndrome syndrome NN cord-015021-pol2qm74 3557 10 and and CC cord-015021-pol2qm74 3557 11 affects affect VBZ cord-015021-pol2qm74 3557 12 intestinal intestinal JJ cord-015021-pol2qm74 3557 13 secretion secretion NN cord-015021-pol2qm74 3557 14 in in IN cord-015021-pol2qm74 3557 15 vitro vitro FW cord-015021-pol2qm74 3557 16 . . . cord-015021-pol2qm74 3558 1 We -PRON- PRP cord-015021-pol2qm74 3558 2 studied study VBD cord-015021-pol2qm74 3558 3 the the DT cord-015021-pol2qm74 3558 4 intestinal intestinal JJ cord-015021-pol2qm74 3558 5 production production NN cord-015021-pol2qm74 3558 6 of of IN cord-015021-pol2qm74 3558 7 IL IL NNP cord-015021-pol2qm74 3558 8 - - HYPH cord-015021-pol2qm74 3558 9 t t NNP cord-015021-pol2qm74 3558 10 and and CC cord-015021-pol2qm74 3558 11 its -PRON- PRP$ cord-015021-pol2qm74 3558 12 effects effect NNS cord-015021-pol2qm74 3558 13 on on IN cord-015021-pol2qm74 3558 14 diarrhea diarrhea NN cord-015021-pol2qm74 3558 15 during during IN cord-015021-pol2qm74 3558 16 endotoxic endotoxic JJ cord-015021-pol2qm74 3558 17 shock shock NN cord-015021-pol2qm74 3558 18 . . . cord-015021-pol2qm74 3559 1 CD-1 CD-1 NNP cord-015021-pol2qm74 3559 2 mice mouse NNS cord-015021-pol2qm74 3559 3 were be VBD cord-015021-pol2qm74 3559 4 randomized randomize VBN cord-015021-pol2qm74 3559 5 to to IN cord-015021-pol2qm74 3559 6 15 15 CD cord-015021-pol2qm74 3559 7 mg mg NNP cord-015021-pol2qm74 3559 8 / / SYM cord-015021-pol2qm74 3559 9 kg kg NNP cord-015021-pol2qm74 3559 10 E.coli E.coli NNS cord-015021-pol2qm74 3559 11 0111 0111 CD cord-015021-pol2qm74 3559 12 : : : cord-015021-pol2qm74 3559 13 B4 B4 NNP cord-015021-pol2qm74 3559 14 LPS LPS NNP cord-015021-pol2qm74 3559 15 or or CC cord-015021-pol2qm74 3559 16 saline saline NN cord-015021-pol2qm74 3559 17 infusion infusion NN cord-015021-pol2qm74 3559 18 ( ( -LRB- cord-015021-pol2qm74 3559 19 I.P. I.P. NNP cord-015021-pol2qm74 3559 20 or or CC cord-015021-pol2qm74 3559 21 I.V. I.V. NNP cord-015021-pol2qm74 3559 22 ) ) -RRB- cord-015021-pol2qm74 3559 23 . . . cord-015021-pol2qm74 3560 1 Diarrhea diarrhea NN cord-015021-pol2qm74 3560 2 invariably invariably RB cord-015021-pol2qm74 3560 3 occurred occur VBD cord-015021-pol2qm74 3560 4 following follow VBG cord-015021-pol2qm74 3560 5 LPS LPS NNP cord-015021-pol2qm74 3560 6 infusion infusion NN cord-015021-pol2qm74 3560 7 . . . cord-015021-pol2qm74 3561 1 Mice mouse NNS cord-015021-pol2qm74 3561 2 were be VBD cord-015021-pol2qm74 3561 3 sacrificed sacrifice VBN cord-015021-pol2qm74 3561 4 at at IN cord-015021-pol2qm74 3561 5 0 0 CD cord-015021-pol2qm74 3561 6 , , , cord-015021-pol2qm74 3561 7 30 30 CD cord-015021-pol2qm74 3561 8 ' ' NNS cord-015021-pol2qm74 3561 9 , , , cord-015021-pol2qm74 3561 10 lh lh NNP cord-015021-pol2qm74 3561 11 , , , cord-015021-pol2qm74 3561 12 2.5h 2.5h CD cord-015021-pol2qm74 3561 13 , , , cord-015021-pol2qm74 3561 14 4h 4h CD cord-015021-pol2qm74 3561 15 , , , cord-015021-pol2qm74 3561 16 6h 6h NNP cord-015021-pol2qm74 3561 17 , , , cord-015021-pol2qm74 3561 18 12h 12h CD cord-015021-pol2qm74 3561 19 , , , cord-015021-pol2qm74 3561 20 and and CC cord-015021-pol2qm74 3561 21 24h 24h NNS cord-015021-pol2qm74 3561 22 ( ( -LRB- cord-015021-pol2qm74 3561 23 3 3 CD cord-015021-pol2qm74 3561 24 mice mouse NNS cord-015021-pol2qm74 3561 25 / / SYM cord-015021-pol2qm74 3561 26 group group NN cord-015021-pol2qm74 3561 27 / / SYM cord-015021-pol2qm74 3561 28 time time NN cord-015021-pol2qm74 3561 29 - - HYPH cord-015021-pol2qm74 3561 30 point point NN cord-015021-pol2qm74 3561 31 ) ) -RRB- cord-015021-pol2qm74 3561 32 . . . cord-015021-pol2qm74 3562 1 The the DT cord-015021-pol2qm74 3562 2 small small JJ cord-015021-pol2qm74 3562 3 bowel bowel NN cord-015021-pol2qm74 3562 4 was be VBD cord-015021-pol2qm74 3562 5 compressed compress VBN cord-015021-pol2qm74 3562 6 and and CC cord-015021-pol2qm74 3562 7 the the DT cord-015021-pol2qm74 3562 8 intestinal intestinal JJ cord-015021-pol2qm74 3562 9 contents content NNS cord-015021-pol2qm74 3562 10 were be VBD cord-015021-pol2qm74 3562 11 weighed weigh VBN cord-015021-pol2qm74 3562 12 and and CC cord-015021-pol2qm74 3562 13 expressed express VBN cord-015021-pol2qm74 3562 14 per per IN cord-015021-pol2qm74 3562 15 g g NN cord-015021-pol2qm74 3562 16 SB SB NNP cord-015021-pol2qm74 3562 17 weight weight NN cord-015021-pol2qm74 3562 18 . . . cord-015021-pol2qm74 3563 1 The the DT cord-015021-pol2qm74 3563 2 small small JJ cord-015021-pol2qm74 3563 3 ( ( -LRB- cord-015021-pol2qm74 3563 4 SB SB NNP cord-015021-pol2qm74 3563 5 ) ) -RRB- cord-015021-pol2qm74 3563 6 and and CC cord-015021-pol2qm74 3563 7 large large JJ cord-015021-pol2qm74 3563 8 bowels bowel NNS cord-015021-pol2qm74 3563 9 ( ( -LRB- cord-015021-pol2qm74 3563 10 LB LB NNP cord-015021-pol2qm74 3563 11 ) ) -RRB- cord-015021-pol2qm74 3563 12 were be VBD cord-015021-pol2qm74 3563 13 eventually eventually RB cord-015021-pol2qm74 3563 14 frozen freeze VBN cord-015021-pol2qm74 3563 15 , , , cord-015021-pol2qm74 3563 16 weighed weigh VBD cord-015021-pol2qm74 3563 17 , , , cord-015021-pol2qm74 3563 18 and and CC cord-015021-pol2qm74 3563 19 homogenized homogenize VBN cord-015021-pol2qm74 3563 20 for for IN cord-015021-pol2qm74 3563 21 either either DT cord-015021-pol2qm74 3563 22 cytosolic cytosolic JJ cord-015021-pol2qm74 3563 23 protein protein NN cord-015021-pol2qm74 3563 24 or or CC cord-015021-pol2qm74 3563 25 total total JJ cord-015021-pol2qm74 3563 26 RNA RNA NNP cord-015021-pol2qm74 3563 27 . . . cord-015021-pol2qm74 3564 1 IL IL NNP cord-015021-pol2qm74 3564 2 - - HYPH cord-015021-pol2qm74 3564 3 I~ I~ NNP cord-015021-pol2qm74 3564 4 ( ( -LRB- cord-015021-pol2qm74 3564 5 cell cell NN cord-015021-pol2qm74 3564 6 - - HYPH cord-015021-pol2qm74 3564 7 associated associate VBN cord-015021-pol2qm74 3564 8 agonist agonist NN cord-015021-pol2qm74 3564 9 ) ) -RRB- cord-015021-pol2qm74 3564 10 was be VBD cord-015021-pol2qm74 3564 11 measured measure VBN cord-015021-pol2qm74 3564 12 with with IN cord-015021-pol2qm74 3564 13 a a DT cord-015021-pol2qm74 3564 14 radioimmunoassay radioimmunoassay JJ cord-015021-pol2qm74 3564 15 specific specific JJ cord-015021-pol2qm74 3564 16 for for IN cord-015021-pol2qm74 3564 17 mouse mouse NN cord-015021-pol2qm74 3564 18 IL IL NNP cord-015021-pol2qm74 3564 19 - - HYPH cord-015021-pol2qm74 3564 20 l~ l~ XX cord-015021-pol2qm74 3565 1 ( ( -LRB- cord-015021-pol2qm74 3565 2 detection detection NN cord-015021-pol2qm74 3565 3 limit limit NN cord-015021-pol2qm74 3565 4 100 100 CD cord-015021-pol2qm74 3565 5 pg pg NN cord-015021-pol2qm74 3565 6 / / SYM cord-015021-pol2qm74 3565 7 mL mL NNP cord-015021-pol2qm74 3565 8 ) ) -RRB- cord-015021-pol2qm74 3565 9 and and CC cord-015021-pol2qm74 3565 10 expressed express VBD cord-015021-pol2qm74 3565 11 as as IN cord-015021-pol2qm74 3565 12 ng ng NNP cord-015021-pol2qm74 3565 13 / / SYM cord-015021-pol2qm74 3565 14 g g NN cord-015021-pol2qm74 3565 15 weight weight NN cord-015021-pol2qm74 3565 16 + + CC cord-015021-pol2qm74 3565 17 SEM sem NN cord-015021-pol2qm74 3565 18 ( ( -LRB- cord-015021-pol2qm74 3565 19 lowest low JJS cord-015021-pol2qm74 3565 20 detectable detectable JJ cord-015021-pol2qm74 3565 21 amount amount NN cord-015021-pol2qm74 3565 22 1 1 CD cord-015021-pol2qm74 3565 23 ng ng NN cord-015021-pol2qm74 3565 24 / / SYM cord-015021-pol2qm74 3565 25 gWT gWT NNP cord-015021-pol2qm74 3565 26 ) ) -RRB- cord-015021-pol2qm74 3565 27 . . . cord-015021-pol2qm74 3566 1 Northern northern JJ cord-015021-pol2qm74 3566 2 analysis analysis NN cord-015021-pol2qm74 3566 3 of of IN cord-015021-pol2qm74 3566 4 total total JJ cord-015021-pol2qm74 3566 5 RNA RNA NNP cord-015021-pol2qm74 3566 6 and and CC cord-015021-pol2qm74 3566 7 in in IN cord-015021-pol2qm74 3566 8 sfu sfu NNP cord-015021-pol2qm74 3566 9 hybridization hybridization NN cord-015021-pol2qm74 3566 10 of of IN cord-015021-pol2qm74 3566 11 paraformaldehyde paraformaldehyde NNP cord-015021-pol2qm74 3566 12 - - HYPH cord-015021-pol2qm74 3566 13 fixed fix VBN cord-015021-pol2qm74 3566 14 frozen frozen JJ cord-015021-pol2qm74 3566 15 tissue tissue NN cord-015021-pol2qm74 3566 16 were be VBD cord-015021-pol2qm74 3566 17 done do VBN cord-015021-pol2qm74 3566 18 with with IN cord-015021-pol2qm74 3566 19 [ [ -LRB- cord-015021-pol2qm74 3566 20 0~-32p]-Iabeled 0~-32p]-iabeled CD cord-015021-pol2qm74 3566 21 mouse mouse NN cord-015021-pol2qm74 3566 22 IL IL NNP cord-015021-pol2qm74 3566 23 - - HYPH cord-015021-pol2qm74 3566 24 lc~ lc~ NN cord-015021-pol2qm74 3566 25 cDNA cdna NN cord-015021-pol2qm74 3566 26 probes probe NNS cord-015021-pol2qm74 3566 27 . . . cord-015021-pol2qm74 3567 1 Only only RB cord-015021-pol2qm74 3567 2 SB SB NNP cord-015021-pol2qm74 3567 3 had have VBD cord-015021-pol2qm74 3567 4 IL IL NNP cord-015021-pol2qm74 3567 5 - - HYPH cord-015021-pol2qm74 3567 6 I~ I~ NNP cord-015021-pol2qm74 3567 7 constitutively constitutively RB cord-015021-pol2qm74 3567 8 present present JJ cord-015021-pol2qm74 3567 9 ( ( -LRB- cord-015021-pol2qm74 3567 10 6.2 6.2 CD cord-015021-pol2qm74 3567 11 + + SYM cord-015021-pol2qm74 3567 12 1.6 1.6 CD cord-015021-pol2qm74 3567 13 ng ng NN cord-015021-pol2qm74 3567 14 / / SYM cord-015021-pol2qm74 3567 15 gWT gWT NNP cord-015021-pol2qm74 3567 16 ) ) -RRB- cord-015021-pol2qm74 3567 17 . . . cord-015021-pol2qm74 3568 1 LPS LPS NNP cord-015021-pol2qm74 3568 2 I.P. I.P. NNP cord-015021-pol2qm74 3568 3 or or CC cord-015021-pol2qm74 3568 4 I.V. I.V. NNP cord-015021-pol2qm74 3568 5 induced induce VBD cord-015021-pol2qm74 3568 6 elevation elevation NN cord-015021-pol2qm74 3568 7 of of IN cord-015021-pol2qm74 3568 8 IL IL NNP cord-015021-pol2qm74 3568 9 - - HYPH cord-015021-pol2qm74 3568 10 lc¢ lc¢ NN cord-015021-pol2qm74 3568 11 in in IN cord-015021-pol2qm74 3568 12 both both DT cord-015021-pol2qm74 3568 13 organs organ NNS cord-015021-pol2qm74 3568 14 in in IN cord-015021-pol2qm74 3568 15 a a DT cord-015021-pol2qm74 3568 16 biphasic biphasic JJ cord-015021-pol2qm74 3568 17 pattern pattern NN cord-015021-pol2qm74 3568 18 ; ; : cord-015021-pol2qm74 3568 19 LPS LPS NNP cord-015021-pol2qm74 3568 20 I.V. I.V. NNP cord-015021-pol2qm74 3568 21 induced induce VBN cord-015021-pol2qm74 3569 1 3-fold 3-fold CD cord-015021-pol2qm74 3569 2 more more JJR cord-015021-pol2qm74 3569 3 IL IL NNP cord-015021-pol2qm74 3569 4 - - HYPH cord-015021-pol2qm74 3569 5 I~ I~ NNP cord-015021-pol2qm74 3569 6 than than IN cord-015021-pol2qm74 3570 1 LPS LPS NNP cord-015021-pol2qm74 3570 2 I.P. I.P. NNP cord-015021-pol2qm74 3570 3 Following follow VBG cord-015021-pol2qm74 3570 4 LPS LPS NNP cord-015021-pol2qm74 3570 5 I.P. I.P. NNP cord-015021-pol2qm74 3570 6 , , , cord-015021-pol2qm74 3570 7 IL IL NNP cord-015021-pol2qm74 3570 8 - - HYPH cord-015021-pol2qm74 3570 9 I~ I~ NNP cord-015021-pol2qm74 3570 10 in in IN cord-015021-pol2qm74 3570 11 SB SB NNP cord-015021-pol2qm74 3570 12 was be VBD cord-015021-pol2qm74 3570 13 19.2 19.2 CD cord-015021-pol2qm74 3570 14 + + SYM cord-015021-pol2qm74 3570 15 0.6 0.6 CD cord-015021-pol2qm74 3570 16 ng ng NN cord-015021-pol2qm74 3570 17 / / SYM cord-015021-pol2qm74 3570 18 gWT gWT NNS cord-015021-pol2qm74 3570 19 at at IN cord-015021-pol2qm74 3570 20 lh lh NNP cord-015021-pol2qm74 3570 21 , , , cord-015021-pol2qm74 3570 22 reached reach VBD cord-015021-pol2qm74 3570 23 maximal maximal JJ cord-015021-pol2qm74 3570 24 levels level NNS cord-015021-pol2qm74 3570 25 at at IN cord-015021-pol2qm74 3570 26 2.5h 2.5h CD cord-015021-pol2qm74 3570 27 ( ( -LRB- cord-015021-pol2qm74 3570 28 31.8 31.8 CD cord-015021-pol2qm74 3570 29 -+ -+ NNP cord-015021-pol2qm74 3570 30 0.5 0.5 CD cord-015021-pol2qm74 3570 31 ng ng NN cord-015021-pol2qm74 3570 32 / / SYM cord-015021-pol2qm74 3570 33 gW gw NN cord-015021-pol2qm74 3570 34 - - : cord-015021-pol2qm74 3570 35 I i NN cord-015021-pol2qm74 3570 36 ) ) -RRB- cord-015021-pol2qm74 3570 37 and and CC cord-015021-pol2qm74 3570 38 returned return VBD cord-015021-pol2qm74 3570 39 to to IN cord-015021-pol2qm74 3570 40 baseline baseline NN cord-015021-pol2qm74 3570 41 at at IN cord-015021-pol2qm74 3570 42 24h 24h NNS cord-015021-pol2qm74 3570 43 . . . cord-015021-pol2qm74 3571 1 Saline Saline NNP cord-015021-pol2qm74 3571 2 controls control NNS cord-015021-pol2qm74 3571 3 maintained maintain VBD cord-015021-pol2qm74 3571 4 their -PRON- PRP$ cord-015021-pol2qm74 3571 5 constitutive constitutive JJ cord-015021-pol2qm74 3571 6 IL IL NNP cord-015021-pol2qm74 3571 7 - - HYPH cord-015021-pol2qm74 3571 8 I~ I~ NNP cord-015021-pol2qm74 3571 9 levels level NNS cord-015021-pol2qm74 3571 10 . . . cord-015021-pol2qm74 3572 1 SB SB NNP cord-015021-pol2qm74 3572 2 had have VBD cord-015021-pol2qm74 3572 3 2fold 2fold CD cord-015021-pol2qm74 3572 4 more more JJR cord-015021-pol2qm74 3572 5 IL-1 IL-1 NNP cord-015021-pol2qm74 3572 6 ¢ ¢ NNP cord-015021-pol2qm74 3572 7 than than IN cord-015021-pol2qm74 3572 8 LB LB NNP cord-015021-pol2qm74 3572 9 and and CC cord-015021-pol2qm74 3572 10 identical identical JJ cord-015021-pol2qm74 3572 11 kinetics kinetic NNS cord-015021-pol2qm74 3572 12 , , , cord-015021-pol2qm74 3572 13 but but CC cord-015021-pol2qm74 3572 14 LB LB NNP cord-015021-pol2qm74 3572 15 showed show VBD cord-015021-pol2qm74 3572 16 a a DT cord-015021-pol2qm74 3572 17 clearer clear JJR cord-015021-pol2qm74 3572 18 doseresponse doseresponse NN cord-015021-pol2qm74 3572 19 . . . cord-015021-pol2qm74 3573 1 Northern northern JJ cord-015021-pol2qm74 3573 2 analysis analysis NN cord-015021-pol2qm74 3573 3 of of IN cord-015021-pol2qm74 3573 4 SB SB NNP cord-015021-pol2qm74 3573 5 - - HYPH cord-015021-pol2qm74 3573 6 total total NNP cord-015021-pol2qm74 3573 7 RNA RNA NNP cord-015021-pol2qm74 3573 8 showed show VBD cord-015021-pol2qm74 3573 9 induction induction NN cord-015021-pol2qm74 3573 10 of of IN cord-015021-pol2qm74 3573 11 IL IL NNP cord-015021-pol2qm74 3573 12 - - HYPH cord-015021-pol2qm74 3573 13 I~ I~ NNP cord-015021-pol2qm74 3573 14 mRNA mrna NN cord-015021-pol2qm74 3573 15 by by IN cord-015021-pol2qm74 3573 16 LPS LPS NNP cord-015021-pol2qm74 3573 17 in in IN cord-015021-pol2qm74 3573 18 correlation correlation NN cord-015021-pol2qm74 3573 19 with with IN cord-015021-pol2qm74 3573 20 IL IL NNP cord-015021-pol2qm74 3573 21 - - HYPH cord-015021-pol2qm74 3573 22 lc¢ lc¢ NN cord-015021-pol2qm74 3573 23 kinetics kinetic NNS cord-015021-pol2qm74 3573 24 . . . cord-015021-pol2qm74 3574 1 IL IL NNP cord-015021-pol2qm74 3574 2 - - HYPH cord-015021-pol2qm74 3574 3 I~ I~ NNP cord-015021-pol2qm74 3575 1 mRNA mrna NN cord-015021-pol2qm74 3575 2 producing produce VBG cord-015021-pol2qm74 3575 3 cells cell NNS cord-015021-pol2qm74 3575 4 were be VBD cord-015021-pol2qm74 3575 5 mononuclear mononuclear JJ cord-015021-pol2qm74 3575 6 cells cell NNS cord-015021-pol2qm74 3575 7 in in IN cord-015021-pol2qm74 3575 8 the the DT cord-015021-pol2qm74 3575 9 lamina lamina JJ cord-015021-pol2qm74 3575 10 propda propda NNP cord-015021-pol2qm74 3575 11 and and CC cord-015021-pol2qm74 3575 12 epithelial epithelial JJ cord-015021-pol2qm74 3575 13 cells cell NNS cord-015021-pol2qm74 3575 14 at at IN cord-015021-pol2qm74 3575 15 the the DT cord-015021-pol2qm74 3575 16 bottom bottom NN cord-015021-pol2qm74 3575 17 of of IN cord-015021-pol2qm74 3575 18 the the DT cord-015021-pol2qm74 3575 19 crypts crypt NNS cord-015021-pol2qm74 3575 20 of of IN cord-015021-pol2qm74 3575 21 Ueberkuhn Ueberkuhn NNP cord-015021-pol2qm74 3575 22 . . . cord-015021-pol2qm74 3576 1 Mucus mucus NN cord-015021-pol2qm74 3576 2 and and CC cord-015021-pol2qm74 3576 3 fluid fluid NN cord-015021-pol2qm74 3576 4 were be VBD cord-015021-pol2qm74 3576 5 increased increase VBN cord-015021-pol2qm74 3576 6 in in IN cord-015021-pol2qm74 3576 7 the the DT cord-015021-pol2qm74 3576 8 small small JJ cord-015021-pol2qm74 3576 9 bowel bowel NN cord-015021-pol2qm74 3576 10 post post NN cord-015021-pol2qm74 3576 11 - - JJ cord-015021-pol2qm74 3576 12 LPS lp NNS cord-015021-pol2qm74 3576 13 in in IN cord-015021-pol2qm74 3576 14 correlation correlation NN cord-015021-pol2qm74 3576 15 with with IN cord-015021-pol2qm74 3576 16 intestinal intestinal JJ cord-015021-pol2qm74 3576 17 IL IL NNP cord-015021-pol2qm74 3576 18 - - HYPH cord-015021-pol2qm74 3576 19 lc~ lc~ NN cord-015021-pol2qm74 3576 20 kinetics kinetic NNS cord-015021-pol2qm74 3576 21 ( ( -LRB- cord-015021-pol2qm74 3576 22 R2=0.9 R2=0.9 NNP cord-015021-pol2qm74 3576 23 ) ) -RRB- cord-015021-pol2qm74 3576 24 . . . cord-015021-pol2qm74 3577 1 Separate separate JJ cord-015021-pol2qm74 3577 2 mice mouse NNS cord-015021-pol2qm74 3577 3 were be VBD cord-015021-pol2qm74 3577 4 pretreated pretreate VBN cord-015021-pol2qm74 3577 5 with with IN cord-015021-pol2qm74 3577 6 saline saline NN cord-015021-pol2qm74 3577 7 I.P. I.P. NNP cord-015021-pol2qm74 3577 8 orthe orthe NN cord-015021-pol2qm74 3577 9 IL-1 IL-1 NNP cord-015021-pol2qm74 3577 10 receptor receptor NN cord-015021-pol2qm74 3577 11 antagonist antagonist NN cord-015021-pol2qm74 3577 12 ( ( -LRB- cord-015021-pol2qm74 3577 13 IRAP IRAP NNP cord-015021-pol2qm74 3577 14 , , , cord-015021-pol2qm74 3577 15 30 30 CD cord-015021-pol2qm74 3577 16 mg mg NN cord-015021-pol2qm74 3577 17 / / SYM cord-015021-pol2qm74 3577 18 kg kg NNP cord-015021-pol2qm74 3577 19 bolus bolus NN cord-015021-pol2qm74 3577 20 I.P. I.P. NNP cord-015021-pol2qm74 3577 21 ) ) -RRB- cord-015021-pol2qm74 3577 22 and and CC cord-015021-pol2qm74 3577 23 were be VBD cord-015021-pol2qm74 3577 24 challenged challenge VBN cord-015021-pol2qm74 3577 25 20 20 CD cord-015021-pol2qm74 3577 26 rain rain NN cord-015021-pol2qm74 3577 27 later later RB cord-015021-pol2qm74 3577 28 with with IN cord-015021-pol2qm74 3577 29 1.5 1.5 CD cord-015021-pol2qm74 3577 30 mg mg NNP cord-015021-pol2qm74 3577 31 / / SYM cord-015021-pol2qm74 3577 32 kg kg NNP cord-015021-pol2qm74 3577 33 LPS LPS NNP cord-015021-pol2qm74 3577 34 I.P. I.P. NNP cord-015021-pol2qm74 3577 35 or or CC cord-015021-pol2qm74 3577 36 saline saline JJ cord-015021-pol2qm74 3577 37 I.P. I.P. NNP cord-015021-pol2qm74 3577 38 Specific specific JJ cord-015021-pol2qm74 3577 39 blockade blockade NN cord-015021-pol2qm74 3577 40 of of IN cord-015021-pol2qm74 3577 41 IL-1 IL-1 NNP cord-015021-pol2qm74 3577 42 by by IN cord-015021-pol2qm74 3577 43 IRAP IRAP NNP cord-015021-pol2qm74 3577 44 decreased decrease VBD cord-015021-pol2qm74 3577 45 intestinal intestinal JJ cord-015021-pol2qm74 3577 46 secretion secretion NN cord-015021-pol2qm74 3577 47 at at IN cord-015021-pol2qm74 3577 48 4h 4h CD cord-015021-pol2qm74 3577 49 and and CC cord-015021-pol2qm74 3577 50 6h 6h NNP cord-015021-pol2qm74 3577 51 post post JJ cord-015021-pol2qm74 3577 52 - - JJ cord-015021-pol2qm74 3577 53 LPS lps JJ cord-015021-pol2qm74 3577 54 challenge challenge NN cord-015021-pol2qm74 3577 55 ( ( -LRB- cord-015021-pol2qm74 3578 1 p p NN cord-015021-pol2qm74 3578 2 < < XX cord-015021-pol2qm74 3578 3 _ _ NNP cord-015021-pol2qm74 3578 4 . . . cord-015021-pol2qm74 3579 1 0.05 0.05 CD cord-015021-pol2qm74 3579 2 , , , cord-015021-pol2qm74 3579 3 Student's Student's NNP cord-015021-pol2qm74 3579 4 - - HYPH cord-015021-pol2qm74 3579 5 t t NN cord-015021-pol2qm74 3579 6 - - HYPH cord-015021-pol2qm74 3579 7 test test NN cord-015021-pol2qm74 3579 8 ) ) -RRB- cord-015021-pol2qm74 3579 9 . . . cord-015021-pol2qm74 3580 1 These these DT cord-015021-pol2qm74 3580 2 data datum NNS cord-015021-pol2qm74 3580 3 indicate indicate VBP cord-015021-pol2qm74 3580 4 that that IN cord-015021-pol2qm74 3580 5 local local JJ cord-015021-pol2qm74 3580 6 ( ( -LRB- cord-015021-pol2qm74 3580 7 intrinsic intrinsic JJ cord-015021-pol2qm74 3580 8 ) ) -RRB- cord-015021-pol2qm74 3580 9 intestinal intestinal JJ cord-015021-pol2qm74 3580 10 IL IL NNP cord-015021-pol2qm74 3580 11 - - HYPH cord-015021-pol2qm74 3580 12 I~ I~ NNP cord-015021-pol2qm74 3580 13 mediates mediate VBZ cord-015021-pol2qm74 3580 14 sepsis sepsis NN cord-015021-pol2qm74 3580 15 - - HYPH cord-015021-pol2qm74 3580 16 induced induce VBN cord-015021-pol2qm74 3580 17 intestinal intestinal JJ cord-015021-pol2qm74 3580 18 changes change NNS cord-015021-pol2qm74 3580 19 . . . cord-015021-pol2qm74 3581 1 Inflammatory inflammatory JJ cord-015021-pol2qm74 3581 2 cytokines cytokine NNS cord-015021-pol2qm74 3581 3 initiate initiate VBP cord-015021-pol2qm74 3581 4 the the DT cord-015021-pol2qm74 3581 5 host host NN cord-015021-pol2qm74 3581 6 response response NN cord-015021-pol2qm74 3581 7 to to IN cord-015021-pol2qm74 3581 8 endotoxemia endotoxemia NN cord-015021-pol2qm74 3581 9 , , , cord-015021-pol2qm74 3581 10 causing cause VBG cord-015021-pol2qm74 3581 11 severe severe JJ cord-015021-pol2qm74 3581 12 physiological physiological JJ cord-015021-pol2qm74 3581 13 and and CC cord-015021-pol2qm74 3581 14 hemodynamic hemodynamic JJ cord-015021-pol2qm74 3581 15 changes change NNS cord-015021-pol2qm74 3581 16 which which WDT cord-015021-pol2qm74 3581 17 may may MD cord-015021-pol2qm74 3581 18 lead lead VB cord-015021-pol2qm74 3581 19 to to IN cord-015021-pol2qm74 3581 20 septic septic JJ cord-015021-pol2qm74 3581 21 shock shock NN cord-015021-pol2qm74 3581 22 . . . cord-015021-pol2qm74 3582 1 Among among IN cord-015021-pol2qm74 3582 2 the the DT cord-015021-pol2qm74 3582 3 regulatory regulatory JJ cord-015021-pol2qm74 3582 4 systems system NNS cord-015021-pol2qm74 3582 5 that that WDT cord-015021-pol2qm74 3582 6 play play VBP cord-015021-pol2qm74 3582 7 an an DT cord-015021-pol2qm74 3582 8 important important JJ cord-015021-pol2qm74 3582 9 rote rote NN cord-015021-pol2qm74 3582 10 in in IN cord-015021-pol2qm74 3582 11 controlling control VBG cord-015021-pol2qm74 3582 12 host host NN cord-015021-pol2qm74 3582 13 inflammatory inflammatory JJ cord-015021-pol2qm74 3582 14 responses response NNS cord-015021-pol2qm74 3582 15 is be VBZ cord-015021-pol2qm74 3582 16 the the DT cord-015021-pol2qm74 3582 17 pituitary pituitary NN cord-015021-pol2qm74 3582 18 . . . cord-015021-pol2qm74 3583 1 It -PRON- PRP cord-015021-pol2qm74 3583 2 has have VBZ cord-015021-pol2qm74 3583 3 been be VBN cord-015021-pol2qm74 3583 4 known know VBN cord-015021-pol2qm74 3583 5 for for IN cord-015021-pol2qm74 3583 6 many many JJ cord-015021-pol2qm74 3583 7 years year NNS cord-015021-pol2qm74 3583 8 for for IN cord-015021-pol2qm74 3583 9 example example NN cord-015021-pol2qm74 3583 10 , , , cord-015021-pol2qm74 3583 11 that that IN cord-015021-pol2qm74 3583 12 hypophysectomized hypophysectomize VBN cord-015021-pol2qm74 3583 13 animals animal NNS cord-015021-pol2qm74 3583 14 are be VBP cord-015021-pol2qm74 3583 15 extremely extremely RB cord-015021-pol2qm74 3583 16 sensitive sensitive JJ cord-015021-pol2qm74 3583 17 to to IN cord-015021-pol2qm74 3583 18 LPS LPS NNP cord-015021-pol2qm74 3583 19 lethality lethality NN cord-015021-pol2qm74 3583 20 . . . cord-015021-pol2qm74 3584 1 While while IN cord-015021-pol2qm74 3584 2 investigating investigate VBG cord-015021-pol2qm74 3584 3 the the DT cord-015021-pol2qm74 3584 4 possibility possibility NN cord-015021-pol2qm74 3584 5 that that IN cord-015021-pol2qm74 3584 6 protective protective JJ cord-015021-pol2qm74 3584 7 , , , cord-015021-pol2qm74 3584 8 pituitary pituitary JJ cord-015021-pol2qm74 3584 9 mediators mediator NNS cord-015021-pol2qm74 3584 10 might may MD cord-015021-pol2qm74 3584 11 explain explain VB cord-015021-pol2qm74 3584 12 this this DT cord-015021-pol2qm74 3584 13 phenomenon phenomenon NN cord-015021-pol2qm74 3584 14 , , , cord-015021-pol2qm74 3584 15 we -PRON- PRP cord-015021-pol2qm74 3584 16 identified identify VBD cord-015021-pol2qm74 3584 17 the the DT cord-015021-pol2qm74 3584 18 cytoldne cytoldne NNP cord-015021-pol2qm74 3584 19 MIF MIF NNP cord-015021-pol2qm74 3584 20 to to TO cord-015021-pol2qm74 3584 21 be be VB cord-015021-pol2qm74 3584 22 a a DT cord-015021-pol2qm74 3584 23 specific specific JJ cord-015021-pol2qm74 3584 24 secretory secretory JJ cord-015021-pol2qm74 3584 25 product product NN cord-015021-pol2qm74 3584 26 produced produce VBN cord-015021-pol2qm74 3584 27 by by IN cord-015021-pol2qm74 3584 28 pituitary pituitary JJ cord-015021-pol2qm74 3584 29 cells cell NNS cord-015021-pol2qm74 3584 30 in in IN cord-015021-pol2qm74 3584 31 vitro vitro FW cord-015021-pol2qm74 3584 32 and and CC cord-015021-pol2qm74 3584 33 in in IN cord-015021-pol2qm74 3584 34 vivo vivo NN cord-015021-pol2qm74 3584 35 after after IN cord-015021-pol2qm74 3584 36 LPS LPS NNP cord-015021-pol2qm74 3584 37 challenge challenge NN cord-015021-pol2qm74 3584 38 . . . cord-015021-pol2qm74 3585 1 Analysis analysis NN cord-015021-pol2qm74 3585 2 of of IN cord-015021-pol2qm74 3585 3 serum serum NN cord-015021-pol2qm74 3585 4 MIF MIF NNP cord-015021-pol2qm74 3585 5 levels level NNS cord-015021-pol2qm74 3585 6 in in IN cord-015021-pol2qm74 3585 7 control control NN cord-015021-pol2qm74 3585 8 , , , cord-015021-pol2qm74 3585 9 T t NN cord-015021-pol2qm74 3585 10 - - HYPH cord-015021-pol2qm74 3585 11 cell cell NN cord-015021-pol2qm74 3585 12 deficient deficient JJ cord-015021-pol2qm74 3585 13 ( ( -LRB- cord-015021-pol2qm74 3585 14 nude nude NNP cord-015021-pol2qm74 3585 15 ) ) -RRB- cord-015021-pol2qm74 3585 16 , , , cord-015021-pol2qm74 3585 17 and and CC cord-015021-pol2qm74 3585 18 hypophysectomized hypophysectomized JJ cord-015021-pol2qm74 3585 19 mice mouse NNS cord-015021-pol2qm74 3585 20 revealed reveal VBD cord-015021-pol2qm74 3585 21 that that IN cord-015021-pol2qm74 3585 22 pituitary pituitary NN cord-015021-pol2qm74 3585 23 - - HYPH cord-015021-pol2qm74 3585 24 derived derive VBN cord-015021-pol2qm74 3585 25 MIF MIF NNP cord-015021-pol2qm74 3585 26 contributes contribute VBZ cord-015021-pol2qm74 3585 27 significantly significantly RB cord-015021-pol2qm74 3585 28 to to IN cord-015021-pol2qm74 3585 29 the the DT cord-015021-pol2qm74 3585 30 rise rise NN cord-015021-pol2qm74 3585 31 in in IN cord-015021-pol2qm74 3585 32 serum serum NN cord-015021-pol2qm74 3585 33 MIF MIF NNP cord-015021-pol2qm74 3585 34 that that WDT cord-015021-pol2qm74 3585 35 occurs occur VBZ cord-015021-pol2qm74 3585 36 after after IN cord-015021-pol2qm74 3585 37 LPS LPS NNP cord-015021-pol2qm74 3585 38 administration administration NN cord-015021-pol2qm74 3585 39 . . . cord-015021-pol2qm74 3586 1 Of of IN cord-015021-pol2qm74 3586 2 note note NN cord-015021-pol2qm74 3586 3 , , , cord-015021-pol2qm74 3586 4 pituitary pituitary NN cord-015021-pol2qm74 3586 5 MIF MIF NNP cord-015021-pol2qm74 3586 6 content content NN cord-015021-pol2qm74 3586 7 ( ( -LRB- cord-015021-pol2qm74 3586 8 0.05 0.05 CD cord-015021-pol2qm74 3586 9 % % NN cord-015021-pol2qm74 3586 10 of of IN cord-015021-pol2qm74 3586 11 total total JJ cord-015021-pol2qm74 3586 12 pituitary pituitary JJ cord-015021-pol2qm74 3586 13 protein protein NN cord-015021-pol2qm74 3586 14 ) ) -RRB- cord-015021-pol2qm74 3586 15 and and CC cord-015021-pol2qm74 3586 16 peak peak NN cord-015021-pol2qm74 3586 17 serum serum NN cord-015021-pol2qm74 3586 18 MIF MIF NNP cord-015021-pol2qm74 3586 19 levels level NNS cord-015021-pol2qm74 3586 20 ( ( -LRB- cord-015021-pol2qm74 3586 21 80 80 CD cord-015021-pol2qm74 3586 22 - - SYM cord-015021-pol2qm74 3586 23 340 340 CD cord-015021-pol2qm74 3586 24 ng ng NN cord-015021-pol2qm74 3586 25 / / SYM cord-015021-pol2qm74 3586 26 ml ml NN cord-015021-pol2qm74 3586 27 ) ) -RRB- cord-015021-pol2qm74 3586 28 were be VBD cord-015021-pol2qm74 3586 29 determined determine VBN cord-015021-pol2qm74 3586 30 to to TO cord-015021-pol2qm74 3586 31 be be VB cord-015021-pol2qm74 3586 32 within within IN cord-015021-pol2qm74 3586 33 the the DT cord-015021-pol2qm74 3586 34 range range NN cord-015021-pol2qm74 3586 35 observed observe VBN cord-015021-pol2qm74 3586 36 for for IN cord-015021-pol2qm74 3586 37 other other JJ cord-015021-pol2qm74 3586 38 pituitary pituitary JJ cord-015021-pol2qm74 3586 39 hormones hormone NNS cord-015021-pol2qm74 3586 40 that that WDT cord-015021-pol2qm74 3586 41 are be VBP cord-015021-pol2qm74 3586 42 released release VBN cord-015021-pol2qm74 3586 43 after after IN cord-015021-pol2qm74 3586 44 pituitary pituitary JJ cord-015021-pol2qm74 3586 45 stimulation stimulation NN cord-015021-pol2qm74 3586 46 . . . cord-015021-pol2qm74 3587 1 To to TO cord-015021-pol2qm74 3587 2 investigate investigate VB cord-015021-pol2qm74 3587 3 a a DT cord-015021-pol2qm74 3587 4 possible possible JJ cord-015021-pol2qm74 3587 5 beneficial beneficial JJ cord-015021-pol2qm74 3587 6 role role NN cord-015021-pol2qm74 3587 7 for for IN cord-015021-pol2qm74 3587 8 MIF MIF NNP cord-015021-pol2qm74 3587 9 in in IN cord-015021-pol2qm74 3587 10 septic septic JJ cord-015021-pol2qm74 3587 11 shock shock NN cord-015021-pol2qm74 3587 12 , , , cord-015021-pol2qm74 3587 13 we -PRON- PRP cord-015021-pol2qm74 3587 14 co co VBD cord-015021-pol2qm74 3587 15 - - VBD cord-015021-pol2qm74 3587 16 injected inject VBN cord-015021-pol2qm74 3587 17 mice mouse NNS cord-015021-pol2qm74 3587 18 with with IN cord-015021-pol2qm74 3587 19 purified purify VBN cord-015021-pol2qm74 3587 20 , , , cord-015021-pol2qm74 3587 21 recombinant recombinant JJ cord-015021-pol2qm74 3587 22 murine murine NN cord-015021-pol2qm74 3587 23 MIF MIF NNP cord-015021-pol2qm74 3587 24 ( ( -LRB- cord-015021-pol2qm74 3587 25 rMIF rmif JJ cord-015021-pol2qm74 3587 26 ) ) -RRB- cord-015021-pol2qm74 3587 27 together together RB cord-015021-pol2qm74 3587 28 with with IN cord-015021-pol2qm74 3587 29 LPS LPS NNP cord-015021-pol2qm74 3587 30 ( ( -LRB- cord-015021-pol2qm74 3587 31 15 15 CD cord-015021-pol2qm74 3587 32 mg mg NNP cord-015021-pol2qm74 3587 33 / / SYM cord-015021-pol2qm74 3587 34 kg kg NNP cord-015021-pol2qm74 3587 35 ) ) -RRB- cord-015021-pol2qm74 3587 36 . . . cord-015021-pol2qm74 3588 1 Surprisingly surprisingly RB cord-015021-pol2qm74 3588 2 , , , cord-015021-pol2qm74 3588 3 rMIF rmif JJ cord-015021-pol2qm74 3588 4 markedly markedly RB cord-015021-pol2qm74 3588 5 potentiated potentiate VBD cord-015021-pol2qm74 3588 6 LPS LPS NNP cord-015021-pol2qm74 3588 7 lethality lethality NN cord-015021-pol2qm74 3588 8 compared compare VBN cord-015021-pol2qm74 3588 9 to to TO cord-015021-pol2qm74 3588 10 control control VB cord-015021-pol2qm74 3588 11 mice mouse NNS cord-015021-pol2qm74 3588 12 that that WDT cord-015021-pol2qm74 3588 13 were be VBD cord-015021-pol2qm74 3588 14 injected inject VBN cord-015021-pol2qm74 3588 15 with with IN cord-015021-pol2qm74 3588 16 LPS LPS NNP cord-015021-pol2qm74 3588 17 alone alone JJ cord-015021-pol2qm74 3588 18 ( ( -LRB- cord-015021-pol2qm74 3588 19 85 85 CD cord-015021-pol2qm74 3588 20 % % NN cord-015021-pol2qm74 3588 21 vs. vs. CC cord-015021-pol2qm74 3588 22 35 35 CD cord-015021-pol2qm74 3588 23 % % NN cord-015021-pol2qm74 3588 24 , , , cord-015021-pol2qm74 3588 25 P p NN cord-015021-pol2qm74 3588 26 = = SYM cord-015021-pol2qm74 3588 27 0.003 0.003 CD cord-015021-pol2qm74 3588 28 ) ) -RRB- cord-015021-pol2qm74 3588 29 . . . cord-015021-pol2qm74 3589 1 To to TO cord-015021-pol2qm74 3589 2 confirm confirm VB cord-015021-pol2qm74 3589 3 these these DT cord-015021-pol2qm74 3589 4 results result NNS cord-015021-pol2qm74 3589 5 , , , cord-015021-pol2qm74 3589 6 mice mouse NNS cord-015021-pol2qm74 3589 7 were be VBD cord-015021-pol2qm74 3589 8 treated treat VBN cord-015021-pol2qm74 3589 9 with with IN cord-015021-pol2qm74 3589 10 anti anti JJ cord-015021-pol2qm74 3589 11 - - JJ cord-015021-pol2qm74 3589 12 rMIF rmif JJ cord-015021-pol2qm74 3589 13 antibody antibody NN cord-015021-pol2qm74 3589 14 prior prior RB cord-015021-pol2qm74 3589 15 to to IN cord-015021-pol2qm74 3589 16 injection injection NN cord-015021-pol2qm74 3589 17 of of IN cord-015021-pol2qm74 3589 18 a a DT cord-015021-pol2qm74 3589 19 high high JJ cord-015021-pol2qm74 3589 20 dose dose NN cord-015021-pol2qm74 3589 21 of of IN cord-015021-pol2qm74 3589 22 LPS LPS NNP cord-015021-pol2qm74 3589 23 ( ( -LRB- cord-015021-pol2qm74 3589 24 17.5 17.5 CD cord-015021-pol2qm74 3589 25 mg mg NNP cord-015021-pol2qm74 3589 26 / / SYM cord-015021-pol2qm74 3589 27 kg kg NNP cord-015021-pol2qm74 3589 28 ) ) -RRB- cord-015021-pol2qm74 3589 29 . . . cord-015021-pol2qm74 3590 1 Anti anti JJ cord-015021-pol2qm74 3590 2 - - JJ cord-015021-pol2qm74 3590 3 rMIF rmif JJ cord-015021-pol2qm74 3590 4 antibody antibody NN cord-015021-pol2qm74 3590 5 fully fully RB cord-015021-pol2qm74 3590 6 protected protect VBD cord-015021-pol2qm74 3590 7 mice mouse NNS cord-015021-pol2qm74 3590 8 against against IN cord-015021-pol2qm74 3590 9 LPS LPS NNP cord-015021-pol2qm74 3590 10 lethality lethality NN cord-015021-pol2qm74 3590 11 , , , cord-015021-pol2qm74 3590 12 increasing increase VBG cord-015021-pol2qm74 3590 13 survival survival NN cord-015021-pol2qm74 3590 14 from from IN cord-015021-pol2qm74 3590 15 50 50 CD cord-015021-pol2qm74 3590 16 % % NN cord-015021-pol2qm74 3590 17 to to TO cord-015021-pol2qm74 3590 18 100 100 CD cord-015021-pol2qm74 3590 19 % % NN cord-015021-pol2qm74 3591 1 ( ( -LRB- cord-015021-pol2qm74 3591 2 P p NN cord-015021-pol2qm74 3591 3 = = SYM cord-015021-pol2qm74 3591 4 0.0004 0.0004 CD cord-015021-pol2qm74 3591 5 ) ) -RRB- cord-015021-pol2qm74 3591 6 . . . cord-015021-pol2qm74 3592 1 Serum serum NN cord-015021-pol2qm74 3592 2 levels level NNS cord-015021-pol2qm74 3592 3 of of IN cord-015021-pol2qm74 3592 4 TNF,~ TNF,~ NNP cord-015021-pol2qm74 3592 5 , , , cord-015021-pol2qm74 3592 6 the the DT cord-015021-pol2qm74 3592 7 first first JJ cord-015021-pol2qm74 3592 8 cytokinc cytokinc NNP cord-015021-pol2qm74 3592 9 that that WDT cord-015021-pol2qm74 3592 10 appears appear VBZ cord-015021-pol2qm74 3592 11 in in IN cord-015021-pol2qm74 3592 12 the the DT cord-015021-pol2qm74 3592 13 circulation circulation NN cord-015021-pol2qm74 3592 14 after after IN cord-015021-pol2qm74 3592 15 LPS LPS NNP cord-015021-pol2qm74 3592 16 challenge challenge NN cord-015021-pol2qm74 3592 17 , , , cord-015021-pol2qm74 3592 18 were be VBD cord-015021-pol2qm74 3592 19 reduced reduce VBN cord-015021-pol2qm74 3592 20 by by IN cord-015021-pol2qm74 3592 21 38.0 38.0 CD cord-015021-pol2qm74 3592 22 _ _ NN cord-015021-pol2qm74 3592 23 + + CC cord-015021-pol2qm74 3592 24 9.5 9.5 CD cord-015021-pol2qm74 3592 25 % % NN cord-015021-pol2qm74 3592 26 in in IN cord-015021-pol2qm74 3592 27 anti anti JJ cord-015021-pol2qm74 3592 28 - - JJ cord-015021-pol2qm74 3592 29 rMIF rmif JJ cord-015021-pol2qm74 3592 30 - - HYPH cord-015021-pol2qm74 3592 31 treated treat VBN cord-015021-pol2qm74 3592 32 mice mouse NNS cord-015021-pol2qm74 3592 33 . . . cord-015021-pol2qm74 3593 1 We -PRON- PRP cord-015021-pol2qm74 3593 2 conclude conclude VBP cord-015021-pol2qm74 3593 3 that that IN cord-015021-pol2qm74 3593 4 pituitary pituitary NN cord-015021-pol2qm74 3593 5 derived derive VBN cord-015021-pol2qm74 3593 6 MIF MIF NNP cord-015021-pol2qm74 3593 7 contributes contribute VBZ cord-015021-pol2qm74 3593 8 significantly significantly RB cord-015021-pol2qm74 3593 9 to to IN cord-015021-pol2qm74 3593 10 circulating circulate VBG cord-015021-pol2qm74 3593 11 MIF MIF NNP cord-015021-pol2qm74 3593 12 in in IN cord-015021-pol2qm74 3593 13 the the DT cord-015021-pol2qm74 3593 14 post post JJ cord-015021-pol2qm74 3593 15 - - JJ cord-015021-pol2qm74 3593 16 acute acute JJ cord-015021-pol2qm74 3593 17 response response NN cord-015021-pol2qm74 3593 18 in in IN cord-015021-pol2qm74 3593 19 endotoxemia endotoxemia NN cord-015021-pol2qm74 3593 20 and and CC cord-015021-pol2qm74 3593 21 may may MD cord-015021-pol2qm74 3593 22 act act VB cord-015021-pol2qm74 3593 23 in in IN cord-015021-pol2qm74 3593 24 concert concert NN cord-015021-pol2qm74 3593 25 with with IN cord-015021-pol2qm74 3593 26 other other JJ cord-015021-pol2qm74 3593 27 pituitary pituitary JJ cord-015021-pol2qm74 3593 28 mediators mediator NNS cord-015021-pol2qm74 3593 29 to to TO cord-015021-pol2qm74 3593 30 regulate regulate VB cord-015021-pol2qm74 3593 31 both both DT cord-015021-pol2qm74 3593 32 pro pro JJ cord-015021-pol2qm74 3593 33 - - JJ cord-015021-pol2qm74 3593 34 and and CC cord-015021-pol2qm74 3593 35 antiinflammatory antiinflammatory JJ cord-015021-pol2qm74 3593 36 effects effect NNS cord-015021-pol2qm74 3593 37 . . . cord-015021-pol2qm74 3594 1 Moreover moreover RB cord-015021-pol2qm74 3594 2 , , , cord-015021-pol2qm74 3594 3 MIF MIF NNP cord-015021-pol2qm74 3594 4 may may MD cord-015021-pol2qm74 3594 5 play play VB cord-015021-pol2qm74 3594 6 a a DT cord-015021-pol2qm74 3594 7 critical critical JJ cord-015021-pol2qm74 3594 8 regulatory regulatory JJ cord-015021-pol2qm74 3594 9 role role NN cord-015021-pol2qm74 3594 10 in in IN cord-015021-pol2qm74 3594 11 the the DT cord-015021-pol2qm74 3594 12 systemic systemic JJ cord-015021-pol2qm74 3594 13 host host NN cord-015021-pol2qm74 3594 14 response response NN cord-015021-pol2qm74 3594 15 in in IN cord-015021-pol2qm74 3594 16 septic septic JJ cord-015021-pol2qm74 3594 17 shock shock NN cord-015021-pol2qm74 3594 18 . . . cord-015021-pol2qm74 3595 1 Our -PRON- PRP$ cord-015021-pol2qm74 3595 2 results result NNS cord-015021-pol2qm74 3595 3 suggest suggest VBP cord-015021-pol2qm74 3595 4 that that IN cord-015021-pol2qm74 3595 5 anti anti JJ cord-015021-pol2qm74 3595 6 - - JJ cord-015021-pol2qm74 3595 7 rMIF rmif JJ cord-015021-pol2qm74 3595 8 antibody antibody NN cord-015021-pol2qm74 3595 9 might may MD cord-015021-pol2qm74 3595 10 be be VB cord-015021-pol2qm74 3595 11 of of IN cord-015021-pol2qm74 3595 12 potential potential JJ cord-015021-pol2qm74 3595 13 therapeutic therapeutic JJ cord-015021-pol2qm74 3595 14 use use NN cord-015021-pol2qm74 3595 15 in in IN cord-015021-pol2qm74 3595 16 the the DT cord-015021-pol2qm74 3595 17 treatment treatment NN cord-015021-pol2qm74 3595 18 of of IN cord-015021-pol2qm74 3595 19 septic septic JJ cord-015021-pol2qm74 3595 20 shock shock NN cord-015021-pol2qm74 3595 21 . . . cord-015021-pol2qm74 3596 1 Although although IN cord-015021-pol2qm74 3596 2 anti anti JJ cord-015021-pol2qm74 3596 3 - - JJ cord-015021-pol2qm74 3596 4 Interleukin-1 interleukin-1 JJ cord-015021-pol2qm74 3596 5 ( ( -LRB- cord-015021-pol2qm74 3596 6 IL-1 IL-1 NNP cord-015021-pol2qm74 3596 7 ) ) -RRB- cord-015021-pol2qm74 3596 8 antibodies antibody NNS cord-015021-pol2qm74 3596 9 and and CC cord-015021-pol2qm74 3596 10 IL-1 IL-1 NNP cord-015021-pol2qm74 3596 11 receptor receptor NN cord-015021-pol2qm74 3596 12 antagonist antagonist NN cord-015021-pol2qm74 3596 13 have have VBP cord-015021-pol2qm74 3596 14 been be VBN cord-015021-pol2qm74 3596 15 shown show VBN cord-015021-pol2qm74 3596 16 to to TO cord-015021-pol2qm74 3596 17 improve improve VB cord-015021-pol2qm74 3596 18 survival survival NN cord-015021-pol2qm74 3596 19 in in IN cord-015021-pol2qm74 3596 20 animal animal NN cord-015021-pol2qm74 3596 21 models model NNS cord-015021-pol2qm74 3596 22 of of IN cord-015021-pol2qm74 3596 23 endotoxemia endotoxemia NN cord-015021-pol2qm74 3596 24 and and CC cord-015021-pol2qm74 3596 25 abrogate abrogate VB cord-015021-pol2qm74 3596 26 the the DT cord-015021-pol2qm74 3596 27 lethal lethal JJ cord-015021-pol2qm74 3596 28 effects effect NNS cord-015021-pol2qm74 3596 29 of of IN cord-015021-pol2qm74 3596 30 TNF TNF NNP cord-015021-pol2qm74 3596 31 , , , cord-015021-pol2qm74 3596 32 the the DT cord-015021-pol2qm74 3596 33 presence presence NN cord-015021-pol2qm74 3596 34 of of IN cord-015021-pol2qm74 3596 35 IL-1 IL-1 NNP cord-015021-pol2qm74 3596 36 in in IN cord-015021-pol2qm74 3596 37 the the DT cord-015021-pol2qm74 3596 38 serum serum NN cord-015021-pol2qm74 3596 39 does do VBZ cord-015021-pol2qm74 3596 40 not not RB cord-015021-pol2qm74 3596 41 correlate correlate VB cord-015021-pol2qm74 3596 42 well well RB cord-015021-pol2qm74 3596 43 with with IN cord-015021-pol2qm74 3596 44 outcome outcome NN cord-015021-pol2qm74 3596 45 . . . cord-015021-pol2qm74 3597 1 We -PRON- PRP cord-015021-pol2qm74 3597 2 hypothesized hypothesize VBD cord-015021-pol2qm74 3597 3 that that IN cord-015021-pol2qm74 3597 4 this this DT cord-015021-pol2qm74 3597 5 may may MD cord-015021-pol2qm74 3597 6 be be VB cord-015021-pol2qm74 3597 7 because because IN cord-015021-pol2qm74 3597 8 IL-1 IL-1 NNP cord-015021-pol2qm74 3597 9 acts act VBZ cord-015021-pol2qm74 3597 10 mainly mainly RB cord-015021-pol2qm74 3597 11 in in IN cord-015021-pol2qm74 3597 12 a a DT cord-015021-pol2qm74 3597 13 paracrine paracrine JJ cord-015021-pol2qm74 3597 14 fashion fashion NN cord-015021-pol2qm74 3597 15 and and CC cord-015021-pol2qm74 3597 16 is be VBZ cord-015021-pol2qm74 3597 17 metabolized metabolize VBN cord-015021-pol2qm74 3597 18 before before IN cord-015021-pol2qm74 3597 19 it -PRON- PRP cord-015021-pol2qm74 3597 20 diffuses diffuse VBZ cord-015021-pol2qm74 3597 21 into into IN cord-015021-pol2qm74 3597 22 the the DT cord-015021-pol2qm74 3597 23 circulation circulation NN cord-015021-pol2qm74 3597 24 . . . cord-015021-pol2qm74 3598 1 Methods method NNS cord-015021-pol2qm74 3598 2 : : : cord-015021-pol2qm74 3598 3 We -PRON- PRP cord-015021-pol2qm74 3598 4 measured measure VBD cord-015021-pol2qm74 3598 5 the the DT cord-015021-pol2qm74 3598 6 IL IL NNP cord-015021-pol2qm74 3598 7 - - HYPH cord-015021-pol2qm74 3598 8 I~ I~ NNP cord-015021-pol2qm74 3598 9 mRNA mRNA NNP cord-015021-pol2qm74 3598 10 expression expression NN cord-015021-pol2qm74 3598 11 with with IN cord-015021-pol2qm74 3598 12 the the DT cord-015021-pol2qm74 3598 13 differential differential JJ cord-015021-pol2qm74 3598 14 reverse reverse NN cord-015021-pol2qm74 3598 15 transcription transcription NN cord-015021-pol2qm74 3598 16 polymerase polymerase NN cord-015021-pol2qm74 3598 17 chain chain NN cord-015021-pol2qm74 3598 18 reaction reaction NN cord-015021-pol2qm74 3598 19 ( ( -LRB- cord-015021-pol2qm74 3598 20 RT RT NNP cord-015021-pol2qm74 3598 21 - - HYPH cord-015021-pol2qm74 3598 22 PCR PCR NNP cord-015021-pol2qm74 3598 23 ) ) -RRB- cord-015021-pol2qm74 3598 24 using use VBG cord-015021-pol2qm74 3598 25 g g NN cord-015021-pol2qm74 3598 26 - - HYPH cord-015021-pol2qm74 3598 27 actin actin NN cord-015021-pol2qm74 3598 28 as as IN cord-015021-pol2qm74 3598 29 internal internal JJ cord-015021-pol2qm74 3598 30 standard standard NN cord-015021-pol2qm74 3598 31 in in IN cord-015021-pol2qm74 3598 32 the the DT cord-015021-pol2qm74 3598 33 peritoneal peritoneal JJ cord-015021-pol2qm74 3598 34 macrophages macrophage NNS cord-015021-pol2qm74 3598 35 and and CC cord-015021-pol2qm74 3598 36 lung lung NN cord-015021-pol2qm74 3598 37 tissue tissue NN cord-015021-pol2qm74 3598 38 in in IN cord-015021-pol2qm74 3598 39 normal normal JJ cord-015021-pol2qm74 3598 40 controls control NNS cord-015021-pol2qm74 3598 41 and and CC cord-015021-pol2qm74 3598 42 mice mouse NNS cord-015021-pol2qm74 3598 43 after after IN cord-015021-pol2qm74 3598 44 cecal cecal JJ cord-015021-pol2qm74 3598 45 ligation ligation NN cord-015021-pol2qm74 3598 46 and and CC cord-015021-pol2qm74 3598 47 puncture puncture NN cord-015021-pol2qm74 3598 48 ( ( -LRB- cord-015021-pol2qm74 3598 49 CLP CLP NNP cord-015021-pol2qm74 3598 50 ) ) -RRB- cord-015021-pol2qm74 3598 51 . . . cord-015021-pol2qm74 3599 1 CLP CLP NNP cord-015021-pol2qm74 3599 2 resembles resemble VBZ cord-015021-pol2qm74 3599 3 human human JJ cord-015021-pol2qm74 3599 4 intra intra JJ cord-015021-pol2qm74 3599 5 - - JJ cord-015021-pol2qm74 3599 6 abdominal abdominal JJ cord-015021-pol2qm74 3599 7 sepsis sepsis NN cord-015021-pol2qm74 3599 8 in in IN cord-015021-pol2qm74 3599 9 that that IN cord-015021-pol2qm74 3599 10 it -PRON- PRP cord-015021-pol2qm74 3599 11 is be VBZ cord-015021-pol2qm74 3599 12 characterized characterize VBN cord-015021-pol2qm74 3599 13 by by IN cord-015021-pol2qm74 3599 14 very very RB cord-015021-pol2qm74 3599 15 slight slight JJ cord-015021-pol2qm74 3599 16 elevations elevation NNS cord-015021-pol2qm74 3599 17 of of IN cord-015021-pol2qm74 3599 18 serum serum NN cord-015021-pol2qm74 3599 19 IL-1 IL-1 NNP cord-015021-pol2qm74 3599 20 levels level NNS cord-015021-pol2qm74 3599 21 . . . cord-015021-pol2qm74 3600 1 Results result NNS cord-015021-pol2qm74 3600 2 : : : cord-015021-pol2qm74 3601 1 IL IL NNP cord-015021-pol2qm74 3601 2 - - HYPH cord-015021-pol2qm74 3601 3 lg lg NNP cord-015021-pol2qm74 3601 4 mRNA mRNA NNP cord-015021-pol2qm74 3601 5 levels level NNS cord-015021-pol2qm74 3601 6 after after IN cord-015021-pol2qm74 3601 7 CLP CLP NNP cord-015021-pol2qm74 3601 8 are be VBP cord-015021-pol2qm74 3601 9 expressed express VBN cord-015021-pol2qm74 3601 10 as as IN cord-015021-pol2qm74 3601 11 % % NN cord-015021-pol2qm74 3601 12 of of IN cord-015021-pol2qm74 3601 13 normal normal JJ cord-015021-pol2qm74 3601 14 ( ( -LRB- cord-015021-pol2qm74 3602 1 mean+SEM mean+sem UH cord-015021-pol2qm74 3602 2 , , , cord-015021-pol2qm74 3602 3 n=5 n=5 JJ cord-015021-pol2qm74 3603 1 In in IN cord-015021-pol2qm74 3603 2 several several JJ cord-015021-pol2qm74 3603 3 experimental experimental JJ cord-015021-pol2qm74 3603 4 models model NNS cord-015021-pol2qm74 3603 5 of of IN cord-015021-pol2qm74 3603 6 infection infection NN cord-015021-pol2qm74 3603 7 exacerbation exacerbation NN cord-015021-pol2qm74 3603 8 of of IN cord-015021-pol2qm74 3603 9 disease disease NN cord-015021-pol2qm74 3603 10 was be VBD cord-015021-pol2qm74 3603 11 observed observe VBN cord-015021-pol2qm74 3603 12 , , , cord-015021-pol2qm74 3603 13 when when WRB cord-015021-pol2qm74 3603 14 infected infected JJ cord-015021-pol2qm74 3603 15 animals animal NNS cord-015021-pol2qm74 3603 16 were be VBD cord-015021-pol2qm74 3603 17 depleted deplete VBN cord-015021-pol2qm74 3603 18 of of IN cord-015021-pol2qm74 3603 19 tuaJor tuajor JJ cord-015021-pol2qm74 3603 20 necrosis necrosis NN cord-015021-pol2qm74 3603 21 factor factor NN cord-015021-pol2qm74 3603 22 ( ( -LRB- cord-015021-pol2qm74 3603 23 TNF TNF NNP cord-015021-pol2qm74 3603 24 ) ) -RRB- cord-015021-pol2qm74 3603 25 . . . cord-015021-pol2qm74 3604 1 After after IN cord-015021-pol2qm74 3604 2 sublethal sublethal JJ cord-015021-pol2qm74 3604 3 cecal cecal JJ cord-015021-pol2qm74 3604 4 ligation ligation NN cord-015021-pol2qm74 3604 5 and and CC cord-015021-pol2qm74 3604 6 puncture puncture NN cord-015021-pol2qm74 3604 7 ( ( -LRB- cord-015021-pol2qm74 3604 8 CLP CLP NNP cord-015021-pol2qm74 3604 9 ) ) -RRB- cord-015021-pol2qm74 3604 10 leading lead VBG cord-015021-pol2qm74 3604 11 to to IN cord-015021-pol2qm74 3604 12 peritonitis peritonitis NN cord-015021-pol2qm74 3604 13 and and CC cord-015021-pol2qm74 3604 14 sepsis sepsis VB cord-015021-pol2qm74 3604 15 the the DT cord-015021-pol2qm74 3604 16 survival survival NN cord-015021-pol2qm74 3604 17 of of IN cord-015021-pol2qm74 3604 18 mice mouse NNS cord-015021-pol2qm74 3604 19 also also RB cord-015021-pol2qm74 3604 20 critically critically RB cord-015021-pol2qm74 3604 21 depends depend VBZ cord-015021-pol2qm74 3604 22 on on IN cord-015021-pol2qm74 3604 23 TNF TNF NNP cord-015021-pol2qm74 3604 24 as as IN cord-015021-pol2qm74 3604 25 demonstrated demonstrate VBN cord-015021-pol2qm74 3604 26 in in IN cord-015021-pol2qm74 3604 27 earlier early JJR cord-015021-pol2qm74 3604 28 studies study NNS cord-015021-pol2qm74 3604 29 , , , cord-015021-pol2qm74 3604 30 when when WRB cord-015021-pol2qm74 3604 31 CLP CLP NNP cord-015021-pol2qm74 3604 32 - - HYPH cord-015021-pol2qm74 3604 33 treated treat VBN cord-015021-pol2qm74 3604 34 mice mouse NNS cord-015021-pol2qm74 3604 35 injected inject VBN cord-015021-pol2qm74 3604 36 with with IN cord-015021-pol2qm74 3604 37 anti anti JJ cord-015021-pol2qm74 3604 38 - - JJ cord-015021-pol2qm74 3604 39 TNF TNF NNP cord-015021-pol2qm74 3604 40 antibody antibody NN cord-015021-pol2qm74 3604 41 died die VBD cord-015021-pol2qm74 3604 42 , , , cord-015021-pol2qm74 3604 43 whereas whereas IN cord-015021-pol2qm74 3604 44 mice mouse NNS cord-015021-pol2qm74 3604 45 injected inject VBD cord-015021-pol2qm74 3604 46 with with IN cord-015021-pol2qm74 3604 47 a a DT cord-015021-pol2qm74 3604 48 control control NN cord-015021-pol2qm74 3604 49 antibody antibody NN cord-015021-pol2qm74 3604 50 survived survive VBD cord-015021-pol2qm74 3604 51 after after IN cord-015021-pol2qm74 3604 52 CLP CLP NNP cord-015021-pol2qm74 3604 53 ( ( -LRB- cord-015021-pol2qm74 3604 54 Echtenacher Echtenacher NNP cord-015021-pol2qm74 3604 55 et et NNP cord-015021-pol2qm74 3604 56 al al NNP cord-015021-pol2qm74 3604 57 . . NNP cord-015021-pol2qm74 3604 58 1990 1990 CD cord-015021-pol2qm74 3604 59 , , , cord-015021-pol2qm74 3604 60 J. J. NNP cord-015021-pol2qm74 3604 61 Inununol Inununol NNP cord-015021-pol2qm74 3604 62 . . . cord-015021-pol2qm74 3605 1 145 145 CD cord-015021-pol2qm74 3605 2 : : SYM cord-015021-pol2qm74 3605 3 3762 3762 CD cord-015021-pol2qm74 3605 4 ) ) -RRB- cord-015021-pol2qm74 3605 5 . . . cord-015021-pol2qm74 3606 1 From from IN cord-015021-pol2qm74 3606 2 a a DT cord-015021-pol2qm74 3606 3 panel panel NN cord-015021-pol2qm74 3606 4 of of IN cord-015021-pol2qm74 3606 5 different different JJ cord-015021-pol2qm74 3606 6 cell cell NN cord-015021-pol2qm74 3606 7 types type NNS cord-015021-pol2qm74 3606 8 ( ( -LRB- cord-015021-pol2qm74 3606 9 macrophages macrophage NNS cord-015021-pol2qm74 3606 10 , , , cord-015021-pol2qm74 3606 11 neutrophils neutrophil NNS cord-015021-pol2qm74 3606 12 , , , cord-015021-pol2qm74 3606 13 T t NN cord-015021-pol2qm74 3606 14 lymphocytes lymphocyte NNS cord-015021-pol2qm74 3606 15 , , , cord-015021-pol2qm74 3606 16 natural natural JJ cord-015021-pol2qm74 3606 17 killer killer NN cord-015021-pol2qm74 3606 18 cells cell NNS cord-015021-pol2qm74 3606 19 , , , cord-015021-pol2qm74 3606 20 mast mast NN cord-015021-pol2qm74 3606 21 cells cell NNS cord-015021-pol2qm74 3606 22 ) ) -RRB- cord-015021-pol2qm74 3606 23 able able JJ cord-015021-pol2qm74 3606 24 to to TO cord-015021-pol2qm74 3606 25 produce produce VB cord-015021-pol2qm74 3606 26 TNF TNF NNP cord-015021-pol2qm74 3606 27 upon upon IN cord-015021-pol2qm74 3606 28 activation~ activation~ NN cord-015021-pol2qm74 3607 1 the the DT cord-015021-pol2qm74 3607 2 mast mast JJ cord-015021-pol2qm74 3607 3 cell cell NN cord-015021-pol2qm74 3607 4 is be VBZ cord-015021-pol2qm74 3607 5 apparantly apparantly RB cord-015021-pol2qm74 3607 6 the the DT cord-015021-pol2qm74 3607 7 only only JJ cord-015021-pol2qm74 3607 8 one one CD cord-015021-pol2qm74 3607 9 capable capable JJ cord-015021-pol2qm74 3607 10 of of IN cord-015021-pol2qm74 3607 11 storing store VBG cord-015021-pol2qm74 3607 12 in in IN cord-015021-pol2qm74 3607 13 cytoplasmic cytoplasmic JJ cord-015021-pol2qm74 3607 14 granules granule NNS cord-015021-pol2qm74 3607 15 preformed preform VBN cord-015021-pol2qm74 3607 16 TNF TNF NNP cord-015021-pol2qm74 3607 17 - - HYPH cord-015021-pol2qm74 3607 18 ct ct NNP cord-015021-pol2qm74 3607 19 which which WDT cord-015021-pol2qm74 3607 20 is be VBZ cord-015021-pol2qm74 3607 21 rapidly rapidly RB cord-015021-pol2qm74 3607 22 released release VBN cord-015021-pol2qm74 3607 23 following follow VBG cord-015021-pol2qm74 3607 24 challenge challenge NN cord-015021-pol2qm74 3607 25 . . . cord-015021-pol2qm74 3608 1 In in IN cord-015021-pol2qm74 3608 2 the the DT cord-015021-pol2qm74 3608 3 present present JJ cord-015021-pol2qm74 3608 4 study study NN cord-015021-pol2qm74 3608 5 - - : cord-015021-pol2qm74 3608 6 we -PRON- PRP cord-015021-pol2qm74 3608 7 analyzed analyze VBD cord-015021-pol2qm74 3608 8 serum serum NN cord-015021-pol2qm74 3608 9 TNF tnf NN cord-015021-pol2qm74 3608 10 after after IN cord-015021-pol2qm74 3608 11 LPS LPS NNP cord-015021-pol2qm74 3608 12 injections injection NNS cord-015021-pol2qm74 3608 13 as as RB cord-015021-pol2qm74 3608 14 well well RB cord-015021-pol2qm74 3608 15 as as IN cord-015021-pol2qm74 3608 16 the the DT cord-015021-pol2qm74 3608 17 outcome outcome NN cord-015021-pol2qm74 3608 18 of of IN cord-015021-pol2qm74 3608 19 CLP CLP NNP cord-015021-pol2qm74 3608 20 in in IN cord-015021-pol2qm74 3608 21 severely severely RB cord-015021-pol2qm74 3608 22 mast mast JJ cord-015021-pol2qm74 3608 23 cell cell NN cord-015021-pol2qm74 3608 24 deficient deficient JJ cord-015021-pol2qm74 3608 25 mutant mutant JJ cord-015021-pol2qm74 3608 26 mice mouse NNS cord-015021-pol2qm74 3608 27 ( ( -LRB- cord-015021-pol2qm74 3608 28 WAV WAV NNP cord-015021-pol2qm74 3608 29 v v NNP cord-015021-pol2qm74 3608 30 ) ) -RRB- cord-015021-pol2qm74 3608 31 as as IN cord-015021-pol2qm74 3608 32 compared compare VBN cord-015021-pol2qm74 3608 33 to to TO cord-015021-pol2qm74 3608 34 syngeaeic syngeaeic VB cord-015021-pol2qm74 3608 35 wild wild JJ cord-015021-pol2qm74 3608 36 - - HYPH cord-015021-pol2qm74 3608 37 type type NN cord-015021-pol2qm74 3608 38 littermates littermate NNS cord-015021-pol2qm74 3608 39 ( ( -LRB- cord-015021-pol2qm74 3608 40 + + CC cord-015021-pol2qm74 3608 41 /+ /+ . cord-015021-pol2qm74 3608 42 ) ) -RRB- cord-015021-pol2qm74 3608 43 . . . cord-015021-pol2qm74 3609 1 We -PRON- PRP cord-015021-pol2qm74 3609 2 proposed propose VBD cord-015021-pol2qm74 3609 3 that that IN cord-015021-pol2qm74 3609 4 concentrations concentration NNS cord-015021-pol2qm74 3609 5 and/or and/or CC cord-015021-pol2qm74 3609 6 kinetics kinetic NNS cord-015021-pol2qm74 3609 7 of of IN cord-015021-pol2qm74 3609 8 serum serum NN cord-015021-pol2qm74 3609 9 TNF TNF NNP cord-015021-pol2qm74 3609 10 should should MD cord-015021-pol2qm74 3609 11 be be VB cord-015021-pol2qm74 3609 12 different different JJ cord-015021-pol2qm74 3609 13 between between IN cord-015021-pol2qm74 3609 14 WAVv WAVv NNS cord-015021-pol2qm74 3609 15 mutants mutant NNS cord-015021-pol2qm74 3609 16 and and CC cord-015021-pol2qm74 3609 17 wild wild JJ cord-015021-pol2qm74 3609 18 - - HYPH cord-015021-pol2qm74 3609 19 type type NN cord-015021-pol2qm74 3609 20 mice mouse NNS cord-015021-pol2qm74 3609 21 , , , cord-015021-pol2qm74 3609 22 if if IN cord-015021-pol2qm74 3609 23 mast mast JJ cord-015021-pol2qm74 3609 24 cell cell NN cord-015021-pol2qm74 3609 25 - - HYPH cord-015021-pol2qm74 3609 26 derived derive VBN cord-015021-pol2qm74 3609 27 TNF TNF NNP cord-015021-pol2qm74 3609 28 significantly significantly RB cord-015021-pol2qm74 3609 29 contributes contribute VBZ cord-015021-pol2qm74 3609 30 to to IN cord-015021-pol2qm74 3609 31 the the DT cord-015021-pol2qm74 3609 32 rise rise NN cord-015021-pol2qm74 3609 33 in in IN cord-015021-pol2qm74 3609 34 serum serum NN cord-015021-pol2qm74 3609 35 TNF tnf NN cord-015021-pol2qm74 3609 36 levels level NNS cord-015021-pol2qm74 3609 37 following follow VBG cord-015021-pol2qm74 3609 38 systemic systemic JJ cord-015021-pol2qm74 3609 39 stimulation stimulation NN cord-015021-pol2qm74 3609 40 with with IN cord-015021-pol2qm74 3609 41 endotoxin endotoxin NN cord-015021-pol2qm74 3609 42 . . . cord-015021-pol2qm74 3610 1 Although although IN cord-015021-pol2qm74 3610 2 similar similar JJ cord-015021-pol2qm74 3610 3 levels level NNS cord-015021-pol2qm74 3610 4 of of IN cord-015021-pol2qm74 3610 5 increased increase VBN cord-015021-pol2qm74 3610 6 TNF TNF NNP cord-015021-pol2qm74 3610 7 were be VBD cord-015021-pol2qm74 3610 8 detected detect VBN cord-015021-pol2qm74 3610 9 in in IN cord-015021-pol2qm74 3610 10 the the DT cord-015021-pol2qm74 3610 11 sera sera NNP cord-015021-pol2qm74 3610 12 of of IN cord-015021-pol2qm74 3610 13 both both DT cord-015021-pol2qm74 3610 14 genotypes genotype NNS cord-015021-pol2qm74 3610 15 after after IN cord-015021-pol2qm74 3610 16 1 1 CD cord-015021-pol2qm74 3610 17 and and CC cord-015021-pol2qm74 3610 18 2 2 CD cord-015021-pol2qm74 3610 19 hours hour NNS cord-015021-pol2qm74 3610 20 of of IN cord-015021-pol2qm74 3610 21 LPS LPS NNP cord-015021-pol2qm74 3610 22 injection injection NN cord-015021-pol2qm74 3610 23 ( ( -LRB- cord-015021-pol2qm74 3610 24 100 100 CD cord-015021-pol2qm74 3610 25 btg/ btg/ NNP cord-015021-pol2qm74 3610 26 0.5 0.5 CD cord-015021-pol2qm74 3610 27 ml ml NN cord-015021-pol2qm74 3610 28 / / SYM cord-015021-pol2qm74 3610 29 mouse mouse NN cord-015021-pol2qm74 3610 30 i. i. NNP cord-015021-pol2qm74 3610 31 p. p. NN cord-015021-pol2qm74 3610 32 ) ) -RRB- cord-015021-pol2qm74 3610 33 , , , cord-015021-pol2qm74 3610 34 mast mast NN cord-015021-pol2qm74 3610 35 ceil ceil NN cord-015021-pol2qm74 3610 36 - - HYPH cord-015021-pol2qm74 3610 37 deficient deficient JJ cord-015021-pol2qm74 3610 38 mice mouse NNS cord-015021-pol2qm74 3610 39 indeed indeed RB cord-015021-pol2qm74 3610 40 showed show VBD cord-015021-pol2qm74 3610 41 decreased decrease VBD cord-015021-pol2qm74 3610 42 serum serum NN cord-015021-pol2qm74 3610 43 TNF TNF NNP cord-015021-pol2qm74 3610 44 levels level NNS cord-015021-pol2qm74 3610 45 30 30 CD cord-015021-pol2qm74 3610 46 iron iron NN cord-015021-pol2qm74 3610 47 after after IN cord-015021-pol2qm74 3610 48 injection injection NN cord-015021-pol2qm74 3610 49 amounting amount VBG cord-015021-pol2qm74 3610 50 to to IN cord-015021-pol2qm74 3610 51 only only RB cord-015021-pol2qm74 3610 52 12 12 CD cord-015021-pol2qm74 3610 53 to to TO cord-015021-pol2qm74 3610 54 25 25 CD cord-015021-pol2qm74 3610 55 % % NN cord-015021-pol2qm74 3610 56 of of IN cord-015021-pol2qm74 3610 57 the the DT cord-015021-pol2qm74 3610 58 concentrations concentration NNS cord-015021-pol2qm74 3610 59 observed observe VBN cord-015021-pol2qm74 3610 60 in in IN cord-015021-pol2qm74 3610 61 the the DT cord-015021-pol2qm74 3610 62 corresponding correspond VBG cord-015021-pol2qm74 3610 63 sera sera NNP cord-015021-pol2qm74 3610 64 of of IN cord-015021-pol2qm74 3610 65 normal normal JJ cord-015021-pol2qm74 3610 66 wildtype wildtype NN cord-015021-pol2qm74 3610 67 mice mouse NNS cord-015021-pol2qm74 3610 68 . . . cord-015021-pol2qm74 3611 1 In in IN cord-015021-pol2qm74 3611 2 the the DT cord-015021-pol2qm74 3611 3 CLP CLP NNP cord-015021-pol2qm74 3611 4 model model NN cord-015021-pol2qm74 3611 5 of of IN cord-015021-pol2qm74 3611 6 septic septic JJ cord-015021-pol2qm74 3611 7 peritonitis peritonitis NN cord-015021-pol2qm74 3611 8 we -PRON- PRP cord-015021-pol2qm74 3611 9 found find VBD cord-015021-pol2qm74 3611 10 that that IN cord-015021-pol2qm74 3611 11 mast mast NN cord-015021-pol2qm74 3611 12 celldeficient celldeficient JJ cord-015021-pol2qm74 3611 13 mutant mutant JJ cord-015021-pol2qm74 3611 14 mice mouse NNS cord-015021-pol2qm74 3611 15 were be VBD cord-015021-pol2qm74 3611 16 dramatically dramatically RB cord-015021-pol2qm74 3611 17 more more RBR cord-015021-pol2qm74 3611 18 sensitive sensitive JJ cord-015021-pol2qm74 3611 19 to to IN cord-015021-pol2qm74 3611 20 CLP CLP NNP cord-015021-pol2qm74 3611 21 than than IN cord-015021-pol2qm74 3611 22 syngeneic syngeneic NNS cord-015021-pol2qm74 3611 23 normal normal JJ cord-015021-pol2qm74 3611 24 mice mouse NNS cord-015021-pol2qm74 3611 25 resulting result VBG cord-015021-pol2qm74 3611 26 in in IN cord-015021-pol2qm74 3611 27 92 92 CD cord-015021-pol2qm74 3611 28 % % NN cord-015021-pol2qm74 3611 29 mortality mortality NN cord-015021-pol2qm74 3611 30 in in IN cord-015021-pol2qm74 3611 31 W W NNP cord-015021-pol2qm74 3611 32 / / SYM cord-015021-pol2qm74 3611 33 W w NN cord-015021-pol2qm74 3611 34 v v NN cord-015021-pol2qm74 3611 35 versus versus IN cord-015021-pol2qm74 3611 36 8 8 CD cord-015021-pol2qm74 3611 37 % % NN cord-015021-pol2qm74 3611 38 mortality mortality NN cord-015021-pol2qm74 3611 39 in in IN cord-015021-pol2qm74 3612 1 + + CC cord-015021-pol2qm74 3612 2 /+ /+ , cord-015021-pol2qm74 3612 3 mice mouse NNS cord-015021-pol2qm74 3612 4 2.5 2.5 CD cord-015021-pol2qm74 3612 5 days day NNS cord-015021-pol2qm74 3612 6 after after IN cord-015021-pol2qm74 3612 7 initiation initiation NN cord-015021-pol2qm74 3612 8 of of IN cord-015021-pol2qm74 3612 9 CLP CLP NNP cord-015021-pol2qm74 3612 10 . . . cord-015021-pol2qm74 3613 1 Further further JJ cord-015021-pol2qm74 3613 2 experiments experiment NNS cord-015021-pol2qm74 3613 3 with with IN cord-015021-pol2qm74 3613 4 W W NNP cord-015021-pol2qm74 3613 5 / / SYM cord-015021-pol2qm74 3613 6 W w NN cord-015021-pol2qm74 3613 7 v v IN cord-015021-pol2qm74 3613 8 mutants mutant NNS cord-015021-pol2qm74 3613 9 selectively selectively RB cord-015021-pol2qm74 3613 10 reconstituted reconstitute VBN cord-015021-pol2qm74 3613 11 with with IN cord-015021-pol2qm74 3613 12 cultured cultured JJ cord-015021-pol2qm74 3613 13 bone bone NN cord-015021-pol2qm74 3613 14 marrow marrow NN cord-015021-pol2qm74 3613 15 - - HYPH cord-015021-pol2qm74 3613 16 derived derive VBN cord-015021-pol2qm74 3613 17 mast mast NN cord-015021-pol2qm74 3613 18 cells cell NNS cord-015021-pol2qm74 3613 19 from from IN cord-015021-pol2qm74 3613 20 normal normal JJ cord-015021-pol2qm74 3613 21 syngeneic syngeneic NNS cord-015021-pol2qm74 3613 22 wild wild JJ cord-015021-pol2qm74 3613 23 - - HYPH cord-015021-pol2qm74 3613 24 type type NN cord-015021-pol2qm74 3613 25 mice mouse NNS cord-015021-pol2qm74 3613 26 and and CC cord-015021-pol2qm74 3613 27 the the DT cord-015021-pol2qm74 3613 28 use use NN cord-015021-pol2qm74 3613 29 of of IN cord-015021-pol2qm74 3613 30 an an DT cord-015021-pol2qm74 3613 31 antibody antibody NN cord-015021-pol2qm74 3613 32 specifically specifically RB cord-015021-pol2qm74 3613 33 blocking block VBG cord-015021-pol2qm74 3613 34 the the DT cord-015021-pol2qm74 3613 35 action action NN cord-015021-pol2qm74 3613 36 of of IN cord-015021-pol2qm74 3613 37 TNF TNF NNP cord-015021-pol2qm74 3613 38 tn tn NNP cord-015021-pol2qm74 3613 39 vivo vivo NN cord-015021-pol2qm74 3613 40 should should MD cord-015021-pol2qm74 3613 41 clarify clarify VB cord-015021-pol2qm74 3613 42 a a DT cord-015021-pol2qm74 3613 43 potential potential JJ cord-015021-pol2qm74 3613 44 protective protective JJ cord-015021-pol2qm74 3613 45 function function NN cord-015021-pol2qm74 3613 46 of of IN cord-015021-pol2qm74 3613 47 mast mast NN cord-015021-pol2qm74 3613 48 cells cell NNS cord-015021-pol2qm74 3613 49 in in IN cord-015021-pol2qm74 3613 50 this this DT cord-015021-pol2qm74 3613 51 model model NN cord-015021-pol2qm74 3613 52 of of IN cord-015021-pol2qm74 3613 53 septic septic JJ cord-015021-pol2qm74 3613 54 peritonitis peritonitis NN cord-015021-pol2qm74 3613 55 . . . cord-015021-pol2qm74 3614 1 Interleukin-10 Interleukin-10 NNP cord-015021-pol2qm74 3614 2 ( ( -LRB- cord-015021-pol2qm74 3614 3 IL-10 IL-10 NNP cord-015021-pol2qm74 3614 4 ) ) -RRB- cord-015021-pol2qm74 3614 5 inhibits inhibit VBZ cord-015021-pol2qm74 3614 6 cytokine cytokine JJ cord-015021-pol2qm74 3614 7 production production NN cord-015021-pol2qm74 3614 8 , , , cord-015021-pol2qm74 3614 9 including include VBG cord-015021-pol2qm74 3614 10 tumor tumor NN cord-015021-pol2qm74 3614 11 necrosis necrosis NN cord-015021-pol2qm74 3614 12 factor factor NN cord-015021-pol2qm74 3614 13 ( ( -LRB- cord-015021-pol2qm74 3614 14 TNF TNF NNP cord-015021-pol2qm74 3614 15 ) ) -RRB- cord-015021-pol2qm74 3614 16 , , , cord-015021-pol2qm74 3614 17 by by IN cord-015021-pol2qm74 3614 18 lipopolysaccharide lipopolysaccharide NN cord-015021-pol2qm74 3614 19 ( ( -LRB- cord-015021-pol2qm74 3614 20 LPS)-aetivated lps)-aetivate VBN cord-015021-pol2qm74 3614 21 maerophages maerophage NNS cord-015021-pol2qm74 3614 22 . . . cord-015021-pol2qm74 3615 1 We -PRON- PRP cord-015021-pol2qm74 3615 2 recently recently RB cord-015021-pol2qm74 3615 3 observed observe VBD cord-015021-pol2qm74 3615 4 that that IN cord-015021-pol2qm74 3615 5 LPS LPS NNP cord-015021-pol2qm74 3615 6 injection injection NN cord-015021-pol2qm74 3615 7 ( ( -LRB- cord-015021-pol2qm74 3615 8 E.coli E.coli NNS cord-015021-pol2qm74 3615 9 055 055 CD cord-015021-pol2qm74 3615 10 : : : cord-015021-pol2qm74 3615 11 B5 B5 NNP cord-015021-pol2qm74 3615 12 , , , cord-015021-pol2qm74 3615 13 100 100 CD cord-015021-pol2qm74 3615 14 gg gg NNP cord-015021-pol2qm74 3615 15 ip ip NN cord-015021-pol2qm74 3615 16 ) ) -RRB- cord-015021-pol2qm74 3615 17 into into IN cord-015021-pol2qm74 3615 18 Balb Balb NNP cord-015021-pol2qm74 3615 19 / / SYM cord-015021-pol2qm74 3615 20 c c NN cord-015021-pol2qm74 3615 21 mice mice NN cord-015021-pol2qm74 3615 22 induces induce VBZ cord-015021-pol2qm74 3615 23 the the DT cord-015021-pol2qm74 3615 24 rapid rapid JJ cord-015021-pol2qm74 3615 25 release release NN cord-015021-pol2qm74 3615 26 of of IN cord-015021-pol2qm74 3615 27 circulating circulate VBG cord-015021-pol2qm74 3615 28 IL-10 IL-10 NNP cord-015021-pol2qm74 3615 29 ( ( -LRB- cord-015021-pol2qm74 3615 30 17±9 17±9 CD cord-015021-pol2qm74 3615 31 U U NNP cord-015021-pol2qm74 3615 32 / / SYM cord-015021-pol2qm74 3615 33 ml ml XX cord-015021-pol2qm74 3615 34 at at IN cord-015021-pol2qm74 3615 35 90 90 CD cord-015021-pol2qm74 3615 36 min min NN cord-015021-pol2qm74 3615 37 ) ) -RRB- cord-015021-pol2qm74 3615 38 . . . cord-015021-pol2qm74 3616 1 Blocking block VBG cord-015021-pol2qm74 3616 2 endogenous endogenous JJ cord-015021-pol2qm74 3616 3 IL-10 IL-10 NNP cord-015021-pol2qm74 3616 4 using use VBG cord-015021-pol2qm74 3616 5 monocIonal monocional JJ cord-015021-pol2qm74 3616 6 antibody antibody NN cord-015021-pol2qm74 3616 7 ( ( -LRB- cord-015021-pol2qm74 3616 8 JES5 JES5 NNP cord-015021-pol2qm74 3616 9 - - HYPH cord-015021-pol2qm74 3616 10 2A5 2a5 CD cord-015021-pol2qm74 3616 11 , , , cord-015021-pol2qm74 3616 12 2 2 CD cord-015021-pol2qm74 3616 13 mg mg NNP cord-015021-pol2qm74 3616 14 , , , cord-015021-pol2qm74 3616 15 2h 2h CD cord-015021-pol2qm74 3616 16 before before IN cord-015021-pol2qm74 3616 17 LPS LPS NNP cord-015021-pol2qm74 3616 18 ) ) -RRB- cord-015021-pol2qm74 3616 19 resulted result VBD cord-015021-pol2qm74 3616 20 in in IN cord-015021-pol2qm74 3616 21 a a DT cord-015021-pol2qm74 3616 22 massive massive JJ cord-015021-pol2qm74 3616 23 increase increase NN cord-015021-pol2qm74 3616 24 in in IN cord-015021-pol2qm74 3616 25 TNF TNF NNP cord-015021-pol2qm74 3616 26 production production NN cord-015021-pol2qm74 3616 27 ( ( -LRB- cord-015021-pol2qm74 3616 28 107±47 107±47 CD cord-015021-pol2qm74 3616 29 in in IN cord-015021-pol2qm74 3617 1 LPS+anti LPS+anti NNP cord-015021-pol2qm74 3617 2 - - HYPH cord-015021-pol2qm74 3617 3 IL-10 IL-10 NNP cord-015021-pol2qm74 3617 4 treated treat VBD cord-015021-pol2qm74 3617 5 mice mouse NNS cord-015021-pol2qm74 3617 6 vs vs IN cord-015021-pol2qm74 3617 7 6±2 6±2 CD cord-015021-pol2qm74 3617 8 ng ng NN cord-015021-pol2qm74 3617 9 / / SYM cord-015021-pol2qm74 3617 10 ml ml NN cord-015021-pol2qm74 3617 11 in in IN cord-015021-pol2qm74 3617 12 LPS LPS NNP cord-015021-pol2qm74 3617 13 alone alone RB cord-015021-pol2qm74 3617 14 , , , cord-015021-pol2qm74 3617 15 p<0.05 p<0.05 CD cord-015021-pol2qm74 3617 16 , , , cord-015021-pol2qm74 3617 17 n=4 n=4 JJ cord-015021-pol2qm74 3617 18 to to IN cord-015021-pol2qm74 3617 19 5 5 CD cord-015021-pol2qm74 3617 20 mice mouse NNS cord-015021-pol2qm74 3617 21 per per IN cord-015021-pol2qm74 3617 22 group group NN cord-015021-pol2qm74 3617 23 ) ) -RRB- cord-015021-pol2qm74 3617 24 and and CC cord-015021-pol2qm74 3617 25 an an DT cord-015021-pol2qm74 3617 26 enhanced enhanced JJ cord-015021-pol2qm74 3617 27 LPS LPS NNP cord-015021-pol2qm74 3617 28 - - HYPH cord-015021-pol2qm74 3617 29 induccd induccd NN cord-015021-pol2qm74 3617 30 lethality lethality NN cord-015021-pol2qm74 3617 31 ( ( -LRB- cord-015021-pol2qm74 3617 32 53 53 CD cord-015021-pol2qm74 3617 33 % % NN cord-015021-pol2qm74 3617 34 vs vs IN cord-015021-pol2qm74 3617 35 7 7 CD cord-015021-pol2qm74 3617 36 % % NN cord-015021-pol2qm74 3617 37 in in IN cord-015021-pol2qm74 3617 38 anti anti JJ cord-015021-pol2qm74 3617 39 - - JJ cord-015021-pol2qm74 3617 40 IL-10+LPS il-10+lps JJ cord-015021-pol2qm74 3617 41 or or CC cord-015021-pol2qm74 3617 42 LPS LPS NNP cord-015021-pol2qm74 3617 43 alone alone RB cord-015021-pol2qm74 3617 44 respectively respectively RB cord-015021-pol2qm74 3617 45 , , , cord-015021-pol2qm74 3617 46 p=0.01 p=0.01 NNP cord-015021-pol2qm74 3617 47 , , , cord-015021-pol2qm74 3617 48 n=15 n=15 JJ cord-015021-pol2qm74 3617 49 mice mouse NNS cord-015021-pol2qm74 3617 50 per per IN cord-015021-pol2qm74 3617 51 group group NN cord-015021-pol2qm74 3617 52 ) ) -RRB- cord-015021-pol2qm74 3617 53 . . . cord-015021-pol2qm74 3618 1 Irrelevant irrelevant JJ cord-015021-pol2qm74 3618 2 IgG1 IgG1 NNP cord-015021-pol2qm74 3618 3 rat rat NN cord-015021-pol2qm74 3618 4 monoclonal monoclonal JJ cord-015021-pol2qm74 3618 5 antibody antibody NN cord-015021-pol2qm74 3618 6 ( ( -LRB- cord-015021-pol2qm74 3618 7 LO LO NNP cord-015021-pol2qm74 3618 8 - - HYPH cord-015021-pol2qm74 3618 9 DNP DNP NNP cord-015021-pol2qm74 3618 10 ) ) -RRB- cord-015021-pol2qm74 3618 11 did do VBD cord-015021-pol2qm74 3618 12 not not RB cord-015021-pol2qm74 3618 13 influence influence VB cord-015021-pol2qm74 3618 14 neither neither CC cord-015021-pol2qm74 3618 15 TNF TNF NNP cord-015021-pol2qm74 3618 16 production production NN cord-015021-pol2qm74 3618 17 nor nor CC cord-015021-pol2qm74 3618 18 lethality lethality NN cord-015021-pol2qm74 3618 19 associated associate VBN cord-015021-pol2qm74 3618 20 with with IN cord-015021-pol2qm74 3618 21 endotoxin endotoxin NN cord-015021-pol2qm74 3618 22 shock shock NN cord-015021-pol2qm74 3618 23 . . . cord-015021-pol2qm74 3619 1 This this DT cord-015021-pol2qm74 3619 2 led lead VBD cord-015021-pol2qm74 3619 3 us -PRON- PRP cord-015021-pol2qm74 3619 4 to to TO cord-015021-pol2qm74 3619 5 study study VB cord-015021-pol2qm74 3619 6 the the DT cord-015021-pol2qm74 3619 7 production production NN cord-015021-pol2qm74 3619 8 of of IN cord-015021-pol2qm74 3619 9 IL-10 IL-10 NNP cord-015021-pol2qm74 3619 10 during during IN cord-015021-pol2qm74 3619 11 human human JJ cord-015021-pol2qm74 3619 12 septicemia septicemia NN cord-015021-pol2qm74 3619 13 . . . cord-015021-pol2qm74 3620 1 Plasma plasma NN cord-015021-pol2qm74 3620 2 samples sample NNS cord-015021-pol2qm74 3620 3 were be VBD cord-015021-pol2qm74 3620 4 obtained obtain VBN cord-015021-pol2qm74 3620 5 from from IN cord-015021-pol2qm74 3620 6 65 65 CD cord-015021-pol2qm74 3620 7 patients patient NNS cord-015021-pol2qm74 3620 8 with with IN cord-015021-pol2qm74 3620 9 gramnegative gramnegative NN cord-015021-pol2qm74 3620 10 ( ( -LRB- cord-015021-pol2qm74 3620 11 GNS GNS NNP cord-015021-pol2qm74 3620 12 , , , cord-015021-pol2qm74 3620 13 n=22 n=22 NNP cord-015021-pol2qm74 3620 14 ) ) -RRB- cord-015021-pol2qm74 3620 15 or or CC cord-015021-pol2qm74 3620 16 gram gram NN cord-015021-pol2qm74 3620 17 - - HYPH cord-015021-pol2qm74 3620 18 positive positive JJ cord-015021-pol2qm74 3620 19 septicemia septicemia NN cord-015021-pol2qm74 3620 20 ( ( -LRB- cord-015021-pol2qm74 3620 21 GPS GPS NNP cord-015021-pol2qm74 3620 22 , , , cord-015021-pol2qm74 3620 23 n=43 n=43 NN cord-015021-pol2qm74 3620 24 ) ) -RRB- cord-015021-pol2qm74 3620 25 and and CC cord-015021-pol2qm74 3620 26 from from IN cord-015021-pol2qm74 3620 27 20 20 CD cord-015021-pol2qm74 3620 28 healthy healthy JJ cord-015021-pol2qm74 3620 29 volunteers volunteer NNS cord-015021-pol2qm74 3620 30 . . . cord-015021-pol2qm74 3621 1 Among among IN cord-015021-pol2qm74 3621 2 these these DT cord-015021-pol2qm74 3621 3 patients patient NNS cord-015021-pol2qm74 3621 4 , , , cord-015021-pol2qm74 3621 5 17 17 CD cord-015021-pol2qm74 3621 6 suffered suffer VBD cord-015021-pol2qm74 3621 7 from from IN cord-015021-pol2qm74 3621 8 septic septic JJ cord-015021-pol2qm74 3621 9 shock shock NN cord-015021-pol2qm74 3621 10 at at IN cord-015021-pol2qm74 3621 11 the the DT cord-015021-pol2qm74 3621 12 time time NN cord-015021-pol2qm74 3621 13 of of IN cord-015021-pol2qm74 3621 14 sampling sampling NN cord-015021-pol2qm74 3621 15 . . . cord-015021-pol2qm74 3622 1 IL-10 IL-10 NNP cord-015021-pol2qm74 3622 2 levels level NNS cord-015021-pol2qm74 3622 3 were be VBD cord-015021-pol2qm74 3622 4 measured measure VBN cord-015021-pol2qm74 3622 5 by by IN cord-015021-pol2qm74 3622 6 ELISA ELISA NNP cord-015021-pol2qm74 3622 7 ( ( -LRB- cord-015021-pol2qm74 3622 8 detection detection NN cord-015021-pol2qm74 3622 9 limit limit NN cord-015021-pol2qm74 3622 10 : : : cord-015021-pol2qm74 3622 11 I i NN cord-015021-pol2qm74 3622 12 1 1 CD cord-015021-pol2qm74 3622 13 pghrd pghrd NNP cord-015021-pol2qm74 3622 14 ) ) -RRB- cord-015021-pol2qm74 3622 15 . . . cord-015021-pol2qm74 3623 1 We -PRON- PRP cord-015021-pol2qm74 3623 2 found find VBD cord-015021-pol2qm74 3623 3 that that IN cord-015021-pol2qm74 3623 4 35 35 CD cord-015021-pol2qm74 3623 5 patients patient NNS cord-015021-pol2qm74 3623 6 ( ( -LRB- cord-015021-pol2qm74 3623 7 54 54 CD cord-015021-pol2qm74 3623 8 % % NN cord-015021-pol2qm74 3623 9 ) ) -RRB- cord-015021-pol2qm74 3623 10 had have VBD cord-015021-pol2qm74 3623 11 increased increase VBN cord-015021-pol2qm74 3623 12 IL-10 IL-10 NNP cord-015021-pol2qm74 3623 13 plasma plasma NN cord-015021-pol2qm74 3623 14 levels level NNS cord-015021-pol2qm74 3623 15 ( ( -LRB- cord-015021-pol2qm74 3623 16 range range VBP cord-015021-pol2qm74 3623 17 12 12 CD cord-015021-pol2qm74 3623 18 to to IN cord-015021-pol2qm74 3623 19 2740 2740 CD cord-015021-pol2qm74 3623 20 pg pg NNP cord-015021-pol2qm74 3623 21 / / SYM cord-015021-pol2qm74 3623 22 nd nd NNP cord-015021-pol2qm74 3623 23 ) ) -RRB- cord-015021-pol2qm74 3623 24 . . . cord-015021-pol2qm74 3624 1 Patients patient NNS cord-015021-pol2qm74 3624 2 with with IN cord-015021-pol2qm74 3624 3 GPS GPS NNP cord-015021-pol2qm74 3624 4 had have VBD cord-015021-pol2qm74 3624 5 IL-10 IL-10 NNP cord-015021-pol2qm74 3624 6 levels level NNS cord-015021-pol2qm74 3624 7 similar similar JJ cord-015021-pol2qm74 3624 8 to to IN cord-015021-pol2qm74 3624 9 the the DT cord-015021-pol2qm74 3624 10 ones one NNS cord-015021-pol2qm74 3624 11 observed observe VBN cord-015021-pol2qm74 3624 12 in in IN cord-015021-pol2qm74 3624 13 GNS GNS NNP cord-015021-pol2qm74 3624 14 ( ( -LRB- cord-015021-pol2qm74 3624 15 median median NN cord-015021-pol2qm74 3624 16 : : : cord-015021-pol2qm74 3624 17 12 12 CD cord-015021-pol2qm74 3624 18 vs vs IN cord-015021-pol2qm74 3624 19 17.5 17.5 CD cord-015021-pol2qm74 3624 20 pg pg NNP cord-015021-pol2qm74 3624 21 / / SYM cord-015021-pol2qm74 3624 22 M M NNP cord-015021-pol2qm74 3624 23 , , , cord-015021-pol2qm74 3624 24 respectively respectively RB cord-015021-pol2qm74 3624 25 ) ) -RRB- cord-015021-pol2qm74 3624 26 . . . cord-015021-pol2qm74 3625 1 Patients patient NNS cord-015021-pol2qm74 3625 2 with with IN cord-015021-pol2qm74 3625 3 septic septic JJ cord-015021-pol2qm74 3625 4 shock shock NN cord-015021-pol2qm74 3625 5 had have VBD cord-015021-pol2qm74 3625 6 higher high JJR cord-015021-pol2qm74 3625 7 IL-10 IL-10 NNP cord-015021-pol2qm74 3625 8 values value NNS cord-015021-pol2qm74 3625 9 ( ( -LRB- cord-015021-pol2qm74 3625 10 median median NN cord-015021-pol2qm74 3625 11 : : : cord-015021-pol2qm74 3625 12 58 58 CD cord-015021-pol2qm74 3625 13 pg pg NN cord-015021-pol2qm74 3625 14 / / SYM cord-015021-pol2qm74 3625 15 ml ml NNP cord-015021-pol2qm74 3625 16 ) ) -RRB- cord-015021-pol2qm74 3625 17 than than IN cord-015021-pol2qm74 3625 18 septicemic septicemic JJ cord-015021-pol2qm74 3625 19 patients patient NNS cord-015021-pol2qm74 3625 20 without without IN cord-015021-pol2qm74 3625 21 shock shock NN cord-015021-pol2qm74 3625 22 ( ( -LRB- cord-015021-pol2qm74 3625 23 11 11 CD cord-015021-pol2qm74 3625 24 pg pg NNP cord-015021-pol2qm74 3625 25 / / SYM cord-015021-pol2qm74 3625 26 ml ml NNS cord-015021-pol2qm74 3625 27 , , , cord-015021-pol2qm74 3625 28 p=0.002 p=0.002 NNP cord-015021-pol2qm74 3625 29 ) ) -RRB- cord-015021-pol2qm74 3625 30 . . . cord-015021-pol2qm74 3626 1 No no UH cord-015021-pol2qm74 3626 2 IL-10 IL-10 NNP cord-015021-pol2qm74 3626 3 was be VBD cord-015021-pol2qm74 3626 4 detected detect VBN cord-015021-pol2qm74 3626 5 in in IN cord-015021-pol2qm74 3626 6 plasma plasma NN cord-015021-pol2qm74 3626 7 from from IN cord-015021-pol2qm74 3626 8 healthy healthy JJ cord-015021-pol2qm74 3626 9 volunteers volunteer NNS cord-015021-pol2qm74 3626 10 . . . cord-015021-pol2qm74 3627 1 We -PRON- PRP cord-015021-pol2qm74 3627 2 conclude conclude VBP cord-015021-pol2qm74 3627 3 that that IN cord-015021-pol2qm74 3627 4 IL-10 IL-10 NNP cord-015021-pol2qm74 3627 5 is be VBZ cord-015021-pol2qm74 3627 6 produced produce VBN cord-015021-pol2qm74 3627 7 daring daring JJ cord-015021-pol2qm74 3627 8 human human JJ cord-015021-pol2qm74 3627 9 septicemia septicemia NN cord-015021-pol2qm74 3627 10 . . . cord-015021-pol2qm74 3628 1 Our -PRON- PRP$ cord-015021-pol2qm74 3628 2 experimental experimental JJ cord-015021-pol2qm74 3628 3 data datum NNS cord-015021-pol2qm74 3628 4 suggest suggest VBP cord-015021-pol2qm74 3628 5 that that IN cord-015021-pol2qm74 3628 6 IL-10 IL-10 NNP cord-015021-pol2qm74 3628 7 might may MD cord-015021-pol2qm74 3628 8 be be VB cord-015021-pol2qm74 3628 9 involved involve VBN cord-015021-pol2qm74 3628 10 in in IN cord-015021-pol2qm74 3628 11 the the DT cord-015021-pol2qm74 3628 12 control control NN cord-015021-pol2qm74 3628 13 of of IN cord-015021-pol2qm74 3628 14 the the DT cord-015021-pol2qm74 3628 15 inflammatory inflammatory JJ cord-015021-pol2qm74 3628 16 response response NN cord-015021-pol2qm74 3628 17 induced induce VBN cord-015021-pol2qm74 3628 18 by by IN cord-015021-pol2qm74 3628 19 bacterial bacterial JJ cord-015021-pol2qm74 3628 20 products product NNS cord-015021-pol2qm74 3628 21 . . . cord-015021-pol2qm74 3629 1 Dr Dr NNP cord-015021-pol2qm74 3629 2 Arnand Arnand NNP cord-015021-pol2qm74 3629 3 Marchant Marchant NNP cord-015021-pol2qm74 3629 4 , , , cord-015021-pol2qm74 3629 5 Immunology Immunology NNP cord-015021-pol2qm74 3629 6 Department Department NNP cord-015021-pol2qm74 3629 7 , , , cord-015021-pol2qm74 3629 8 Hopital Hopital NNP cord-015021-pol2qm74 3629 9 Erasme Erasme NNP cord-015021-pol2qm74 3629 10 , , , cord-015021-pol2qm74 3629 11 808 808 CD cord-015021-pol2qm74 3629 12 Route Route NNP cord-015021-pol2qm74 3629 13 de de NNP cord-015021-pol2qm74 3629 14 Lennik Lennik NNP cord-015021-pol2qm74 3629 15 , , , cord-015021-pol2qm74 3629 16 1070 1070 CD cord-015021-pol2qm74 3629 17 Brussels Brussels NNP cord-015021-pol2qm74 3629 18 , , , cord-015021-pol2qm74 3629 19 Belgium Belgium NNP cord-015021-pol2qm74 3629 20 . . . cord-015021-pol2qm74 3629 21 _SP cord-015021-pol2qm74 3630 1 To to TO cord-015021-pol2qm74 3630 2 provide provide VB cord-015021-pol2qm74 3630 3 information information NN cord-015021-pol2qm74 3630 4 about about IN cord-015021-pol2qm74 3630 5 the the DT cord-015021-pol2qm74 3630 6 role role NN cord-015021-pol2qm74 3630 7 of of IN cord-015021-pol2qm74 3630 8 TNF TNF NNP cord-015021-pol2qm74 3630 9 in in IN cord-015021-pol2qm74 3630 10 sepsis sepsis NN cord-015021-pol2qm74 3630 11 and and CC cord-015021-pol2qm74 3630 12 MODS mods NN cord-015021-pol2qm74 3630 13 we -PRON- PRP cord-015021-pol2qm74 3630 14 measured measure VBD cord-015021-pol2qm74 3630 15 TNF TNF NNP cord-015021-pol2qm74 3630 16 and and CC cord-015021-pol2qm74 3630 17 sTNFR stnfr RB cord-015021-pol2qm74 3630 18 - - HYPH cord-015021-pol2qm74 3630 19 I -PRON- PRP cord-015021-pol2qm74 3630 20 levels level NNS cord-015021-pol2qm74 3630 21 in in IN cord-015021-pol2qm74 3630 22 septic septic JJ cord-015021-pol2qm74 3630 23 patients patient NNS cord-015021-pol2qm74 3630 24 and and CC cord-015021-pol2qm74 3630 25 investigated investigate VBN cord-015021-pol2qm74 3630 26 if if IN cord-015021-pol2qm74 3630 27 there there EX cord-015021-pol2qm74 3630 28 is be VBZ cord-015021-pol2qm74 3630 29 a a DT cord-015021-pol2qm74 3630 30 relation relation NN cord-015021-pol2qm74 3630 31 between between IN cord-015021-pol2qm74 3630 32 plasma plasma NN cord-015021-pol2qm74 3630 33 concentration concentration NN cord-015021-pol2qm74 3630 34 of of IN cord-015021-pol2qm74 3630 35 these these DT cord-015021-pol2qm74 3630 36 molecules molecule NNS cord-015021-pol2qm74 3630 37 and and CC cord-015021-pol2qm74 3630 38 the the DT cord-015021-pol2qm74 3630 39 severity severity NN cord-015021-pol2qm74 3630 40 of of IN cord-015021-pol2qm74 3630 41 sepsis sepsis NN cord-015021-pol2qm74 3630 42 evaluated evaluate VBN cord-015021-pol2qm74 3630 43 by by IN cord-015021-pol2qm74 3630 44 two two CD cord-015021-pol2qm74 3630 45 scores score NNS cord-015021-pol2qm74 3630 46 ( ( -LRB- cord-015021-pol2qm74 3630 47 APACHE APACHE NNP cord-015021-pol2qm74 3630 48 1I 1I NNP cord-015021-pol2qm74 3630 49 and and CC cord-015021-pol2qm74 3630 50 SSS SSS NNP cord-015021-pol2qm74 3630 51 ) ) -RRB- cord-015021-pol2qm74 3630 52 . . . cord-015021-pol2qm74 3631 1 Patients Patients NNP cord-015021-pol2qm74 3631 2 and and CC cord-015021-pol2qm74 3631 3 Melhods Melhods NNP cord-015021-pol2qm74 3631 4 : : : cord-015021-pol2qm74 3631 5 20 20 CD cord-015021-pol2qm74 3631 6 septic septic JJ cord-015021-pol2qm74 3631 7 patients patient NNS cord-015021-pol2qm74 3631 8 fullfilling fullfille VBG cord-015021-pol2qm74 3631 9 sepsis sepsis NN cord-015021-pol2qm74 3631 10 criteria criterion NNS cord-015021-pol2qm74 3631 11 of of IN cord-015021-pol2qm74 3631 12 American American NNP cord-015021-pol2qm74 3631 13 College College NNP cord-015021-pol2qm74 3631 14 of of IN cord-015021-pol2qm74 3631 15 Chest Chest NNP cord-015021-pol2qm74 3631 16 Physician Physician NNP cord-015021-pol2qm74 3631 17 and and CC cord-015021-pol2qm74 3631 18 Society Society NNP cord-015021-pol2qm74 3631 19 of of IN cord-015021-pol2qm74 3631 20 Critical Critical NNP cord-015021-pol2qm74 3631 21 Care Care NNP cord-015021-pol2qm74 3631 22 Medicine Medicine NNP cord-015021-pol2qm74 3631 23 were be VBD cord-015021-pol2qm74 3631 24 studied study VBN cord-015021-pol2qm74 3631 25 . . . cord-015021-pol2qm74 3632 1 TNF TNF NNP cord-015021-pol2qm74 3632 2 - - HYPH cord-015021-pol2qm74 3632 3 cc cc NNP cord-015021-pol2qm74 3632 4 and and CC cord-015021-pol2qm74 3632 5 STNFR STNFR NNP cord-015021-pol2qm74 3632 6 - - HYPH cord-015021-pol2qm74 3632 7 I I NNP cord-015021-pol2qm74 3632 8 ( ( -LRB- cord-015021-pol2qm74 3632 9 60kDa 60kDa NNP cord-015021-pol2qm74 3632 10 ) ) -RRB- cord-015021-pol2qm74 3632 11 were be VBD cord-015021-pol2qm74 3632 12 measured measure VBN cord-015021-pol2qm74 3632 13 by by IN cord-015021-pol2qm74 3632 14 enzyme enzyme NN cord-015021-pol2qm74 3632 15 immuneassays immuneassay NNS cord-015021-pol2qm74 3632 16 ( ( -LRB- cord-015021-pol2qm74 3632 17 norms1 norms1 NNP cord-015021-pol2qm74 3632 18 values value NNS cord-015021-pol2qm74 3632 19 = = . cord-015021-pol2qm74 3633 1 13 13 CD cord-015021-pol2qm74 3633 2 + + SYM cord-015021-pol2qm74 3633 3 8 8 CD cord-015021-pol2qm74 3633 4 pg pg NN cord-015021-pol2qm74 3633 5 / / SYM cord-015021-pol2qm74 3633 6 mL ml NN cord-015021-pol2qm74 3633 7 and and CC cord-015021-pol2qm74 3633 8 1.06_+0A 1.06_+0a CD cord-015021-pol2qm74 3633 9 ng ng NN cord-015021-pol2qm74 3633 10 / / SYM cord-015021-pol2qm74 3633 11 mL ml NN cord-015021-pol2qm74 3633 12 respectively respectively RB cord-015021-pol2qm74 3633 13 ) ) -RRB- cord-015021-pol2qm74 3633 14 . . . cord-015021-pol2qm74 3634 1 Results result NNS cord-015021-pol2qm74 3634 2 : : : cord-015021-pol2qm74 3635 1 The the DT cord-015021-pol2qm74 3635 2 mean mean JJ cord-015021-pol2qm74 3635 3 TNF TNF NNP cord-015021-pol2qm74 3635 4 and and CC cord-015021-pol2qm74 3635 5 sTNFR stnfr RB cord-015021-pol2qm74 3635 6 - - HYPH cord-015021-pol2qm74 3635 7 I -PRON- PRP cord-015021-pol2qm74 3635 8 values value NNS cord-015021-pol2qm74 3635 9 for for IN cord-015021-pol2qm74 3635 10 each each DT cord-015021-pol2qm74 3635 11 patient patient NN cord-015021-pol2qm74 3635 12 ( ( -LRB- cord-015021-pol2qm74 3635 13 mean+SD mean+SD NNP cord-015021-pol2qm74 3635 14 ) ) -RRB- cord-015021-pol2qm74 3635 15 were be VBD cord-015021-pol2qm74 3635 16 93 93 CD cord-015021-pol2qm74 3635 17 + + SYM cord-015021-pol2qm74 3635 18 64 64 CD cord-015021-pol2qm74 3635 19 pg pg NN cord-015021-pol2qm74 3635 20 / / SYM cord-015021-pol2qm74 3635 21 mL ml NN cord-015021-pol2qm74 3635 22 and and CC cord-015021-pol2qm74 3636 1 11.1 11.1 CD cord-015021-pol2qm74 3636 2 + + SYM cord-015021-pol2qm74 3636 3 5.5 5.5 CD cord-015021-pol2qm74 3636 4 ng ng NN cord-015021-pol2qm74 3636 5 / / SYM cord-015021-pol2qm74 3636 6 mL ml NN cord-015021-pol2qm74 3636 7 respectively respectively RB cord-015021-pol2qm74 3636 8 . . . cord-015021-pol2qm74 3637 1 These these DT cord-015021-pol2qm74 3637 2 values value NNS cord-015021-pol2qm74 3637 3 are be VBP cord-015021-pol2qm74 3637 4 approximately approximately RB cord-015021-pol2qm74 3637 5 seven seven CD cord-015021-pol2qm74 3637 6 and and CC cord-015021-pol2qm74 3637 7 ten ten CD cord-015021-pol2qm74 3637 8 times time NNS cord-015021-pol2qm74 3637 9 greater great JJR cord-015021-pol2qm74 3637 10 than than IN cord-015021-pol2qm74 3637 11 those those DT cord-015021-pol2qm74 3637 12 observed observe VBN cord-015021-pol2qm74 3637 13 in in IN cord-015021-pol2qm74 3637 14 normal normal JJ cord-015021-pol2qm74 3637 15 healthy healthy JJ cord-015021-pol2qm74 3637 16 volunteers volunteer NNS cord-015021-pol2qm74 3637 17 ( ( -LRB- cord-015021-pol2qm74 3637 18 P<0.001 P<0.001 NNP cord-015021-pol2qm74 3637 19 ) ) -RRB- cord-015021-pol2qm74 3637 20 . . . cord-015021-pol2qm74 3638 1 Mean Mean NNP cord-015021-pol2qm74 3638 2 TNF TNF NNP cord-015021-pol2qm74 3638 3 concentrations concentration NNS cord-015021-pol2qm74 3638 4 for for IN cord-015021-pol2qm74 3638 5 each each DT cord-015021-pol2qm74 3638 6 patient patient NN cord-015021-pol2qm74 3638 7 were be VBD cord-015021-pol2qm74 3638 8 significantly significantly RB cord-015021-pol2qm74 3638 9 greater great JJR cord-015021-pol2qm74 3638 10 in in IN cord-015021-pol2qm74 3638 11 non non JJ cord-015021-pol2qm74 3638 12 survivors survivor NNS cord-015021-pol2qm74 3638 13 ( ( -LRB- cord-015021-pol2qm74 3638 14 112 112 CD cord-015021-pol2qm74 3638 15 + + SYM cord-015021-pol2qm74 3638 16 52 52 CD cord-015021-pol2qm74 3638 17 vs vs IN cord-015021-pol2qm74 3638 18 64_+74 64_+74 CD cord-015021-pol2qm74 3638 19 pg pg NNP cord-015021-pol2qm74 3638 20 / / SYM cord-015021-pol2qm74 3638 21 ml ml NN cord-015021-pol2qm74 3638 22 P<0.05 P<0.05 NNS cord-015021-pol2qm74 3638 23 ) ) -RRB- cord-015021-pol2qm74 3638 24 ; ; : cord-015021-pol2qm74 3638 25 sTNFR stnfr RBR cord-015021-pol2qm74 3638 26 - - HYPH cord-015021-pol2qm74 3638 27 I -PRON- PRP cord-015021-pol2qm74 3638 28 levels level NNS cord-015021-pol2qm74 3638 29 also also RB cord-015021-pol2qm74 3638 30 were be VBD cord-015021-pol2qm74 3638 31 greater great JJR cord-015021-pol2qm74 3638 32 in in IN cord-015021-pol2qm74 3638 33 this this DT cord-015021-pol2qm74 3638 34 group group NN cord-015021-pol2qm74 3638 35 , , , cord-015021-pol2qm74 3638 36 but but CC cord-015021-pol2qm74 3638 37 the the DT cord-015021-pol2qm74 3638 38 difference difference NN cord-015021-pol2qm74 3638 39 was be VBD cord-015021-pol2qm74 3638 40 not not RB cord-015021-pol2qm74 3638 41 statistically statistically RB cord-015021-pol2qm74 3638 42 significant significant JJ cord-015021-pol2qm74 3638 43 ( ( -LRB- cord-015021-pol2qm74 3638 44 12.6 12.6 CD cord-015021-pol2qm74 3638 45 + + SYM cord-015021-pol2qm74 3638 46 5.2 5.2 CD cord-015021-pol2qm74 3638 47 vs vs IN cord-015021-pol2qm74 3638 48 8.8_+5.5 8.8_+5.5 CD cord-015021-pol2qm74 3638 49 ng ng NNP cord-015021-pol2qm74 3638 50 / / SYM cord-015021-pol2qm74 3638 51 ml ml NN cord-015021-pol2qm74 3638 52 ) ) -RRB- cord-015021-pol2qm74 3638 53 . . . cord-015021-pol2qm74 3639 1 Plasma Plasma NNP cord-015021-pol2qm74 3639 2 TNF TNF NNP cord-015021-pol2qm74 3639 3 and and CC cord-015021-pol2qm74 3639 4 sTNFR stnfr RB cord-015021-pol2qm74 3639 5 - - HYPH cord-015021-pol2qm74 3639 6 I -PRON- PRP cord-015021-pol2qm74 3639 7 concentrations concentration NNS cord-015021-pol2qm74 3639 8 were be VBD cord-015021-pol2qm74 3639 9 significantly significantly RB cord-015021-pol2qm74 3639 10 correlated correlate VBN cord-015021-pol2qm74 3639 11 ( ( -LRB- cord-015021-pol2qm74 3639 12 r r NN cord-015021-pol2qm74 3639 13 = = NN cord-015021-pol2qm74 3639 14 0.65 0.65 CD cord-015021-pol2qm74 3639 15 P<0.005 P<0.005 NNP cord-015021-pol2qm74 3639 16 ) ) -RRB- cord-015021-pol2qm74 3639 17 . . . cord-015021-pol2qm74 3640 1 Mean mean JJ cord-015021-pol2qm74 3640 2 TNF TNF NNP cord-015021-pol2qm74 3640 3 levels level NNS cord-015021-pol2qm74 3640 4 were be VBD cord-015021-pol2qm74 3640 5 significantly significantly RB cord-015021-pol2qm74 3640 6 correlated correlate VBN cord-015021-pol2qm74 3640 7 with with IN cord-015021-pol2qm74 3640 8 APACHE APACHE NNP cord-015021-pol2qm74 3640 9 II II NNP cord-015021-pol2qm74 3640 10 ( ( -LRB- cord-015021-pol2qm74 3640 11 r r NN cord-015021-pol2qm74 3640 12 = = SYM cord-015021-pol2qm74 3640 13 0.49 0.49 CD cord-015021-pol2qm74 3640 14 P<0.05 P<0.05 NNS cord-015021-pol2qm74 3640 15 ) ) -RRB- cord-015021-pol2qm74 3640 16 and and CC cord-015021-pol2qm74 3640 17 SSS SSS NNP cord-015021-pol2qm74 3640 18 ( ( -LRB- cord-015021-pol2qm74 3640 19 r r NN cord-015021-pol2qm74 3640 20 = = NN cord-015021-pol2qm74 3640 21 0.54 0.54 CD cord-015021-pol2qm74 3640 22 P p NN cord-015021-pol2qm74 3640 23 < < XX cord-015021-pol2qm74 3640 24 O.01 o.01 CD cord-015021-pol2qm74 3640 25 ) ) -RRB- cord-015021-pol2qm74 3640 26 ; ; : cord-015021-pol2qm74 3640 27 sTNFR stnfr RBR cord-015021-pol2qm74 3640 28 - - HYPH cord-015021-pol2qm74 3640 29 I -PRON- PRP cord-015021-pol2qm74 3640 30 levels level NNS cord-015021-pol2qm74 3640 31 were be VBD cord-015021-pol2qm74 3640 32 likewise likewise RB cord-015021-pol2qm74 3640 33 correlated correlate VBN cord-015021-pol2qm74 3640 34 with with IN cord-015021-pol2qm74 3640 35 both both DT cord-015021-pol2qm74 3640 36 scores score NNS cord-015021-pol2qm74 3640 37 ( ( -LRB- cord-015021-pol2qm74 3640 38 r r NN cord-015021-pol2qm74 3640 39 = = NN cord-015021-pol2qm74 3640 40 0.80 0.80 CD cord-015021-pol2qm74 3640 41 P<0.001 P<0.001 NNS cord-015021-pol2qm74 3640 42 and and CC cord-015021-pol2qm74 3640 43 r r NN cord-015021-pol2qm74 3640 44 = = SYM cord-015021-pol2qm74 3640 45 0.76 0.76 CD cord-015021-pol2qm74 3640 46 P<0.001 P<0.001 NNS cord-015021-pol2qm74 3640 47 respectively respectively RB cord-015021-pol2qm74 3640 48 ) ) -RRB- cord-015021-pol2qm74 3640 49 . . . cord-015021-pol2qm74 3641 1 TNF TNF NNP cord-015021-pol2qm74 3641 2 and and CC cord-015021-pol2qm74 3641 3 sTNFqGI stnfqgi NN cord-015021-pol2qm74 3641 4 levels level NNS cord-015021-pol2qm74 3641 5 increase increase VBP cord-015021-pol2qm74 3641 6 with with IN cord-015021-pol2qm74 3641 7 the the DT cord-015021-pol2qm74 3641 8 number number NN cord-015021-pol2qm74 3641 9 of of IN cord-015021-pol2qm74 3641 10 dysfuctional dysfuctional JJ cord-015021-pol2qm74 3641 11 organs organ NNS cord-015021-pol2qm74 3641 12 ; ; : cord-015021-pol2qm74 3641 13 in in IN cord-015021-pol2qm74 3641 14 particular particular JJ cord-015021-pol2qm74 3641 15 TNF TNF NNP cord-015021-pol2qm74 3641 16 and and CC cord-015021-pol2qm74 3641 17 STNFR STNFR NNP cord-015021-pol2qm74 3641 18 - - : cord-015021-pol2qm74 3641 19 I -PRON- PRP cord-015021-pol2qm74 3641 20 increase increase VBP cord-015021-pol2qm74 3641 21 when when WRB cord-015021-pol2qm74 3641 22 hemodynamics hemodynamic NNS cord-015021-pol2qm74 3641 23 deteriorate deteriorate VBP cord-015021-pol2qm74 3641 24 and and CC cord-015021-pol2qm74 3641 25 kidney kidney NN cord-015021-pol2qm74 3641 26 failure failure NN cord-015021-pol2qm74 3641 27 ensues ensue VBZ cord-015021-pol2qm74 3641 28 . . . cord-015021-pol2qm74 3642 1 Conclusions conclusion NNS cord-015021-pol2qm74 3642 2 : : : cord-015021-pol2qm74 3643 1 The the DT cord-015021-pol2qm74 3643 2 correlations correlation NNS cord-015021-pol2qm74 3643 3 between between IN cord-015021-pol2qm74 3643 4 TNF TNF NNP cord-015021-pol2qm74 3643 5 and and CC cord-015021-pol2qm74 3643 6 sTNFR stnfr RB cord-015021-pol2qm74 3643 7 - - HYPH cord-015021-pol2qm74 3643 8 I -PRON- PRP cord-015021-pol2qm74 3643 9 levels level NNS cord-015021-pol2qm74 3643 10 and and CC cord-015021-pol2qm74 3643 11 sepsis sepsis NN cord-015021-pol2qm74 3643 12 severity severity NN cord-015021-pol2qm74 3643 13 scores score NNS cord-015021-pol2qm74 3643 14 suggests suggest VBZ cord-015021-pol2qm74 3643 15 that that IN cord-015021-pol2qm74 3643 16 TNF TNF NNP cord-015021-pol2qm74 3643 17 is be VBZ cord-015021-pol2qm74 3643 18 involved involve VBN cord-015021-pol2qm74 3643 19 in in IN cord-015021-pol2qm74 3643 20 sepsis sepsis NN cord-015021-pol2qm74 3643 21 and and CC cord-015021-pol2qm74 3643 22 may may MD cord-015021-pol2qm74 3643 23 influence influence VB cord-015021-pol2qm74 3643 24 the the DT cord-015021-pol2qm74 3643 25 occurrence occurrence NN cord-015021-pol2qm74 3643 26 of of IN cord-015021-pol2qm74 3643 27 MODS mods NN cord-015021-pol2qm74 3643 28 and and CC cord-015021-pol2qm74 3643 29 finally finally RB cord-015021-pol2qm74 3643 30 clinical clinical JJ cord-015021-pol2qm74 3643 31 outcome outcome NN cord-015021-pol2qm74 3643 32 . . . cord-015021-pol2qm74 3644 1 TNF TNF NNP cord-015021-pol2qm74 3644 2 and and CC cord-015021-pol2qm74 3644 3 sTNFR sTNFR NNP cord-015021-pol2qm74 3645 1 -I -I NNP cord-015021-pol2qm74 3645 2 are be VBP cord-015021-pol2qm74 3645 3 in in IN cord-015021-pol2qm74 3645 4 fact fact NN cord-015021-pol2qm74 3645 5 especially especially RB cord-015021-pol2qm74 3645 6 increased increase VBN cord-015021-pol2qm74 3645 7 when when WRB cord-015021-pol2qm74 3645 8 MODS mods NN cord-015021-pol2qm74 3645 9 occurs occur VBZ cord-015021-pol2qm74 3645 10 . . . cord-015021-pol2qm74 3646 1 In in IN cord-015021-pol2qm74 3646 2 particular particular JJ cord-015021-pol2qm74 3646 3 their -PRON- PRP$ cord-015021-pol2qm74 3646 4 concentrations concentration NNS cord-015021-pol2qm74 3646 5 are be VBP cord-015021-pol2qm74 3646 6 elevated elevate VBN cord-015021-pol2qm74 3646 7 when when WRB cord-015021-pol2qm74 3646 8 cardiovascular cardiovascular JJ cord-015021-pol2qm74 3646 9 system system NN cord-015021-pol2qm74 3646 10 and and CC cord-015021-pol2qm74 3646 11 kidney kidney NN cord-015021-pol2qm74 3646 12 failure failure NN cord-015021-pol2qm74 3646 13 ensue ensue NN cord-015021-pol2qm74 3646 14 , , , cord-015021-pol2qm74 3646 15 suggesting suggest VBG cord-015021-pol2qm74 3646 16 that that IN cord-015021-pol2qm74 3646 17 TNF TNF NNP cord-015021-pol2qm74 3646 18 can can MD cord-015021-pol2qm74 3646 19 have have VB cord-015021-pol2qm74 3646 20 a a DT cord-015021-pol2qm74 3646 21 direct direct JJ cord-015021-pol2qm74 3646 22 role role NN cord-015021-pol2qm74 3646 23 in in IN cord-015021-pol2qm74 3646 24 hemodynamic hemodynamic JJ cord-015021-pol2qm74 3646 25 derangements derangement NNS cord-015021-pol2qm74 3646 26 caused cause VBN cord-015021-pol2qm74 3646 27 by by IN cord-015021-pol2qm74 3646 28 sepsis sepsis NN cord-015021-pol2qm74 3646 29 and and CC cord-015021-pol2qm74 3646 30 that that IN cord-015021-pol2qm74 3646 31 kidneys kidney NNS cord-015021-pol2qm74 3646 32 are be VBP cord-015021-pol2qm74 3646 33 involved involve VBN cord-015021-pol2qm74 3646 34 in in IN cord-015021-pol2qm74 3646 35 TNF TNF NNP cord-015021-pol2qm74 3646 36 and and CC cord-015021-pol2qm74 3646 37 sTNFR stnfr RB cord-015021-pol2qm74 3646 38 - - : cord-015021-pol2qm74 3646 39 I -PRON- PRP cord-015021-pol2qm74 3646 40 excretion excretion NN cord-015021-pol2qm74 3646 41 . . . cord-015021-pol2qm74 3647 1 LIF LIF NNP cord-015021-pol2qm74 3647 2 is be VBZ cord-015021-pol2qm74 3647 3 a a DT cord-015021-pol2qm74 3647 4 pleiotropic pleiotropic JJ cord-015021-pol2qm74 3647 5 cytokine cytokine NN cord-015021-pol2qm74 3647 6 that that WDT cord-015021-pol2qm74 3647 7 has have VBZ cord-015021-pol2qm74 3647 8 been be VBN cord-015021-pol2qm74 3647 9 implicated implicate VBN cord-015021-pol2qm74 3647 10 in in IN cord-015021-pol2qm74 3647 11 the the DT cord-015021-pol2qm74 3647 12 pathogenesis pathogenesis NN cord-015021-pol2qm74 3647 13 of of IN cord-015021-pol2qm74 3647 14 sepsis sepsis NN cord-015021-pol2qm74 3647 15 in in IN cord-015021-pol2qm74 3647 16 animal animal NN cord-015021-pol2qm74 3647 17 models model NNS cord-015021-pol2qm74 3647 18 . . . cord-015021-pol2qm74 3648 1 We -PRON- PRP cord-015021-pol2qm74 3648 2 conducted conduct VBD cord-015021-pol2qm74 3648 3 a a DT cord-015021-pol2qm74 3648 4 prospective prospective JJ cord-015021-pol2qm74 3648 5 study study NN cord-015021-pol2qm74 3648 6 in in IN cord-015021-pol2qm74 3648 7 33 33 CD cord-015021-pol2qm74 3648 8 septic septic JJ cord-015021-pol2qm74 3648 9 patients patient NNS cord-015021-pol2qm74 3648 10 to to TO cord-015021-pol2qm74 3648 11 correlate correlate VB cord-015021-pol2qm74 3648 12 LIF LIF NNP cord-015021-pol2qm74 3648 13 plasma plasma NN cord-015021-pol2qm74 3648 14 levels level NNS cord-015021-pol2qm74 3648 15 with with IN cord-015021-pol2qm74 3648 16 patient patient NN cord-015021-pol2qm74 3648 17 's 's POS cord-015021-pol2qm74 3648 18 clinical clinical JJ cord-015021-pol2qm74 3648 19 and and CC cord-015021-pol2qm74 3648 20 biological biological JJ cord-015021-pol2qm74 3648 21 data datum NNS cord-015021-pol2qm74 3648 22 ( ( -LRB- cord-015021-pol2qm74 3648 23 among among IN cord-015021-pol2qm74 3648 24 them -PRON- PRP cord-015021-pol2qm74 3648 25 IL-6 IL-6 NNP cord-015021-pol2qm74 3648 26 ) ) -RRB- cord-015021-pol2qm74 3648 27 . . . cord-015021-pol2qm74 3649 1 Plasma plasma NN cord-015021-pol2qm74 3649 2 was be VBD cord-015021-pol2qm74 3649 3 drawn draw VBN cord-015021-pol2qm74 3649 4 daily daily RB cord-015021-pol2qm74 3649 5 from from IN cord-015021-pol2qm74 3649 6 day day NN cord-015021-pol2qm74 3649 7 one one CD cord-015021-pol2qm74 3649 8 to to IN cord-015021-pol2qm74 3649 9 .ten .ten . cord-015021-pol2qm74 3650 1 and and CC cord-015021-pol2qm74 3650 2 LIF LIF NNP cord-015021-pol2qm74 3650 3 presence presence NN cord-015021-pol2qm74 3650 4 was be VBD cord-015021-pol2qm74 3650 5 determined determine VBN cord-015021-pol2qm74 3650 6 with with IN cord-015021-pol2qm74 3650 7 a a DT cord-015021-pol2qm74 3650 8 specific specific JJ cord-015021-pol2qm74 3650 9 ELISA ELISA NNP cord-015021-pol2qm74 3650 10 and and CC cord-015021-pol2qm74 3650 11 with with IN cord-015021-pol2qm74 3650 12 the the DT cord-015021-pol2qm74 3650 13 DAI DAI NNP cord-015021-pol2qm74 3650 14 , , , cord-015021-pol2qm74 3650 15 a a DT cord-015021-pol2qm74 3650 16 bioassay bioassay NN cord-015021-pol2qm74 3650 17 ( ( -LRB- cord-015021-pol2qm74 3650 18 sensitivity sensitivity NN cord-015021-pol2qm74 3650 19 of of IN cord-015021-pol2qm74 3650 20 100 100 CD cord-015021-pol2qm74 3650 21 pg pg NN cord-015021-pol2qm74 3650 22 / / SYM cord-015021-pol2qm74 3650 23 ml ml NN cord-015021-pol2qm74 3650 24 and and CC cord-015021-pol2qm74 3650 25 1 1 CD cord-015021-pol2qm74 3650 26 ngml ngml NNP cord-015021-pol2qm74 3650 27 respectively respectively RB cord-015021-pol2qm74 3650 28 ) ) -RRB- cord-015021-pol2qm74 3650 29 . . . cord-015021-pol2qm74 3651 1 Risk risk NN cord-015021-pol2qm74 3651 2 factor factor NN cord-015021-pol2qm74 3651 3 associated associate VBN cord-015021-pol2qm74 3652 1 wftt~ wftt~ NNP cord-015021-pol2qm74 3652 2 with with IN cord-015021-pol2qm74 3652 3 elevated elevated JJ cord-015021-pol2qm74 3652 4 LIF LIF NNP cord-015021-pol2qm74 3652 5 plasma plasma NN cord-015021-pol2qm74 3652 6 level level NN cord-015021-pol2qm74 3652 7 was be VBD cord-015021-pol2qm74 3652 8 determined determine VBN cord-015021-pol2qm74 3652 9 by by IN cord-015021-pol2qm74 3652 10 an an DT cord-015021-pol2qm74 3652 11 univariate univariate JJ cord-015021-pol2qm74 3652 12 analysis analysis NN cord-015021-pol2qm74 3652 13 . . . cord-015021-pol2qm74 3653 1 A a DT cord-015021-pol2qm74 3653 2 multivariate multivariate JJ cord-015021-pol2qm74 3653 3 stepwise stepwise JJ cord-015021-pol2qm74 3653 4 logistic logistic JJ cord-015021-pol2qm74 3653 5 regression regression NN cord-015021-pol2qm74 3653 6 analysis analysis NN cord-015021-pol2qm74 3653 7 was be VBD cord-015021-pol2qm74 3653 8 subsequently subsequently RB cord-015021-pol2qm74 3653 9 performed perform VBN cord-015021-pol2qm74 3653 10 with with IN cord-015021-pol2qm74 3653 11 a a DT cord-015021-pol2qm74 3653 12 BMDP BMDP NNP cord-015021-pol2qm74 3653 13 statistical statistical JJ cord-015021-pol2qm74 3653 14 software software NN cord-015021-pol2qm74 3653 15 . . . cord-015021-pol2qm74 3654 1 LIF LIF NNP cord-015021-pol2qm74 3654 2 was be VBD cord-015021-pol2qm74 3654 3 detected detect VBN cord-015021-pol2qm74 3654 4 with with IN cord-015021-pol2qm74 3654 5 the the DT cord-015021-pol2qm74 3654 6 ELISA ELISA NNP cord-015021-pol2qm74 3654 7 and and CC cord-015021-pol2qm74 3654 8 with with IN cord-015021-pol2qm74 3654 9 the the DT cord-015021-pol2qm74 3654 10 bioassay bioassay NN cord-015021-pol2qm74 3654 11 in in IN cord-015021-pol2qm74 3654 12 11 11 CD cord-015021-pol2qm74 3654 13 and and CC cord-015021-pol2qm74 3654 14 2 2 CD cord-015021-pol2qm74 3654 15 out out IN cord-015021-pol2qm74 3654 16 of of IN cord-015021-pol2qm74 3654 17 the the DT cord-015021-pol2qm74 3654 18 33 33 CD cord-015021-pol2qm74 3654 19 patients patient NNS cord-015021-pol2qm74 3654 20 , , , cord-015021-pol2qm74 3654 21 respectively respectively RB cord-015021-pol2qm74 3654 22 . . . cord-015021-pol2qm74 3655 1 LIF LIF NNP cord-015021-pol2qm74 3655 2 peak peak NN cord-015021-pol2qm74 3655 3 plasma plasma NN cord-015021-pol2qm74 3655 4 levels level NNS cord-015021-pol2qm74 3655 5 were be VBD cord-015021-pol2qm74 3655 6 statistically statistically RB cord-015021-pol2qm74 3655 7 associated associate VBN cord-015021-pol2qm74 3655 8 with with IN cord-015021-pol2qm74 3655 9 high high JJ cord-015021-pol2qm74 3655 10 creatmin creatmin JJ cord-015021-pol2qm74 3655 11 levels level NNS cord-015021-pol2qm74 3655 12 , , , cord-015021-pol2qm74 3655 13 temperature temperature NN cord-015021-pol2qm74 3655 14 and and CC cord-015021-pol2qm74 3655 15 IL-6 IL-6 NNP cord-015021-pol2qm74 3655 16 . . . cord-015021-pol2qm74 3656 1 Multivariate multivariate JJ cord-015021-pol2qm74 3656 2 regression regression NN cord-015021-pol2qm74 3656 3 analysis analysis NN cord-015021-pol2qm74 3656 4 showed show VBD cord-015021-pol2qm74 3656 5 that that IN cord-015021-pol2qm74 3656 6 high high JJ cord-015021-pol2qm74 3656 7 serum serum NN cord-015021-pol2qm74 3656 8 creatinin creatinin NNS cord-015021-pol2qm74 3656 9 level level NN cord-015021-pol2qm74 3656 10 was be VBD cord-015021-pol2qm74 3656 11 the the DT cord-015021-pol2qm74 3656 12 major major JJ cord-015021-pol2qm74 3656 13 independent independent JJ cord-015021-pol2qm74 3656 14 risk risk NN cord-015021-pol2qm74 3656 15 factor factor NN cord-015021-pol2qm74 3656 16 associated associate VBN cord-015021-pol2qm74 3656 17 with with IN cord-015021-pol2qm74 3656 18 elevated elevated JJ cord-015021-pol2qm74 3656 19 LIFplasma LIFplasma NNP cord-015021-pol2qm74 3656 20 levels level NNS cord-015021-pol2qm74 3656 21 . . . cord-015021-pol2qm74 3657 1 This this DT cord-015021-pol2qm74 3657 2 correlation correlation NN cord-015021-pol2qm74 3657 3 was be VBD cord-015021-pol2qm74 3657 4 also also RB cord-015021-pol2qm74 3657 5 found find VBN cord-015021-pol2qm74 3657 6 for for IN cord-015021-pol2qm74 3657 7 IL-6 IL-6 NNP cord-015021-pol2qm74 3657 8 . . . cord-015021-pol2qm74 3658 1 Peak peak NN cord-015021-pol2qm74 3658 2 plasma plasma NN cord-015021-pol2qm74 3658 3 levels level NNS cord-015021-pol2qm74 3658 4 of of IN cord-015021-pol2qm74 3658 5 both both CC cord-015021-pol2qm74 3658 6 LIF LIF NNP cord-015021-pol2qm74 3658 7 and and CC cord-015021-pol2qm74 3658 8 IL-6 IL-6 NNP cord-015021-pol2qm74 3658 9 correlated correlate VBD cord-015021-pol2qm74 3658 10 inversely inversely RB cord-015021-pol2qm74 3658 11 with with IN cord-015021-pol2qm74 3658 12 patients patient NNS cord-015021-pol2qm74 3658 13 survival survival NN cord-015021-pol2qm74 3658 14 duration duration NN cord-015021-pol2qm74 3658 15 . . . cord-015021-pol2qm74 3659 1 Cox Cox NNP cord-015021-pol2qm74 3659 2 's 's POS cord-015021-pol2qm74 3659 3 analysis analysis NN cord-015021-pol2qm74 3659 4 for for IN cord-015021-pol2qm74 3659 5 plasma plasma NN cord-015021-pol2qm74 3659 6 levels level NNS cord-015021-pol2qm74 3659 7 of of IN cord-015021-pol2qm74 3659 8 LIF LIF NNP cord-015021-pol2qm74 3659 9 > > XX cord-015021-pol2qm74 3660 1 480 480 CD cord-015021-pol2qm74 3660 2 pg pg NN cord-015021-pol2qm74 3660 3 / / SYM cord-015021-pol2qm74 3660 4 ml ml CC cord-015021-pol2qm74 3660 5 yelded yelde VBD cord-015021-pol2qm74 3660 6 a a DT cord-015021-pol2qm74 3660 7 hazard hazard NN cord-015021-pol2qm74 3660 8 ratio ratio NN cord-015021-pol2qm74 3660 9 of of IN cord-015021-pol2qm74 3660 10 [ [ -LRB- cord-015021-pol2qm74 3660 11 exp exp NN cord-015021-pol2qm74 3660 12 ( ( -LRB- cord-015021-pol2qm74 3660 13 1.86)=6.44 1.86)=6.44 CD cord-015021-pol2qm74 3660 14 ] ] -RRB- cord-015021-pol2qm74 3660 15 . . . cord-015021-pol2qm74 3661 1 Our -PRON- PRP$ cord-015021-pol2qm74 3661 2 study study NN cord-015021-pol2qm74 3661 3 indicates indicate VBZ cord-015021-pol2qm74 3661 4 that that IN cord-015021-pol2qm74 3661 5 LIF LIF NNP cord-015021-pol2qm74 3661 6 levels level NNS cord-015021-pol2qm74 3661 7 were be VBD cord-015021-pol2qm74 3661 8 associated associate VBN cord-015021-pol2qm74 3661 9 with with IN cord-015021-pol2qm74 3661 10 clinical clinical JJ cord-015021-pol2qm74 3661 11 and and CC cord-015021-pol2qm74 3661 12 biological biological JJ cord-015021-pol2qm74 3661 13 parameters parameter NNS cord-015021-pol2qm74 3661 14 of of IN cord-015021-pol2qm74 3661 15 illness illness NN cord-015021-pol2qm74 3661 16 severity severity NN cord-015021-pol2qm74 3661 17 and and CC cord-015021-pol2qm74 3661 18 significantly significantly RB cord-015021-pol2qm74 3661 19 increased increase VBD cord-015021-pol2qm74 3661 20 ( ( -LRB- cord-015021-pol2qm74 3661 21 cut cut VBN cord-015021-pol2qm74 3661 22 - - HYPH cord-015021-pol2qm74 3661 23 off off RP cord-015021-pol2qm74 3661 24 value value NN cord-015021-pol2qm74 3661 25 480 480 CD cord-015021-pol2qm74 3661 26 pg pg NNP cord-015021-pol2qm74 3661 27 / / SYM cord-015021-pol2qm74 3661 28 mI mI NNP cord-015021-pol2qm74 3661 29 ) ) -RRB- cord-015021-pol2qm74 3661 30 in in IN cord-015021-pol2qm74 3661 31 patients patient NNS cord-015021-pol2qm74 3661 32 with with IN cord-015021-pol2qm74 3661 33 fatal fatal JJ cord-015021-pol2qm74 3661 34 outcome outcome NN cord-015021-pol2qm74 3661 35 . . . cord-015021-pol2qm74 3662 1 Current current JJ cord-015021-pol2qm74 3662 2 consensus consensus NN cord-015021-pol2qm74 3662 3 exists exist VBZ cord-015021-pol2qm74 3662 4 about about IN cord-015021-pol2qm74 3662 5 the the DT cord-015021-pol2qm74 3662 6 central central JJ cord-015021-pol2qm74 3662 7 role role NN cord-015021-pol2qm74 3662 8 of of IN cord-015021-pol2qm74 3662 9 tumor tumor NN cord-015021-pol2qm74 3662 10 necrosis necrosis NN cord-015021-pol2qm74 3662 11 factor factor NN cord-015021-pol2qm74 3662 12 ( ( -LRB- cord-015021-pol2qm74 3662 13 TNF TNF NNP cord-015021-pol2qm74 3662 14 ) ) -RRB- cord-015021-pol2qm74 3662 15 alpha alpha NN cord-015021-pol2qm74 3662 16 in in IN cord-015021-pol2qm74 3662 17 initiating initiate VBG cord-015021-pol2qm74 3662 18 the the DT cord-015021-pol2qm74 3662 19 systemic systemic JJ cord-015021-pol2qm74 3662 20 inflammatory inflammatory JJ cord-015021-pol2qm74 3662 21 response response NN cord-015021-pol2qm74 3662 22 syndrome syndrome NN cord-015021-pol2qm74 3662 23 ( ( -LRB- cord-015021-pol2qm74 3662 24 SIRS SIRS NNP cord-015021-pol2qm74 3662 25 ) ) -RRB- cord-015021-pol2qm74 3662 26 . . . cord-015021-pol2qm74 3663 1 A a DT cord-015021-pol2qm74 3663 2 correlation correlation NN cord-015021-pol2qm74 3663 3 with with IN cord-015021-pol2qm74 3663 4 SIRS SIRS NNP cord-015021-pol2qm74 3663 5 has have VBZ cord-015021-pol2qm74 3663 6 inconsistently inconsistently RB cord-015021-pol2qm74 3663 7 been be VBN cord-015021-pol2qm74 3663 8 found find VBN cord-015021-pol2qm74 3663 9 . . . cord-015021-pol2qm74 3664 1 TNF TNF NNP cord-015021-pol2qm74 3664 2 effects effect VBZ cord-015021-pol2qm74 3664 3 its -PRON- PRP$ cord-015021-pol2qm74 3664 4 pleiotropic pleiotropic JJ cord-015021-pol2qm74 3664 5 reactions reaction NNS cord-015021-pol2qm74 3664 6 upon upon IN cord-015021-pol2qm74 3664 7 two two CD cord-015021-pol2qm74 3664 8 distinct distinct JJ cord-015021-pol2qm74 3664 9 cellular cellular JJ cord-015021-pol2qm74 3664 10 receptors receptor NNS cord-015021-pol2qm74 3664 11 . . . cord-015021-pol2qm74 3665 1 Soluble soluble JJ cord-015021-pol2qm74 3665 2 extracel]ular extracel]ular JJ cord-015021-pol2qm74 3665 3 fragments fragment NNS cord-015021-pol2qm74 3665 4 of of IN cord-015021-pol2qm74 3665 5 the the DT cord-015021-pol2qm74 3665 6 human human JJ cord-015021-pol2qm74 3665 7 55 55 CD cord-015021-pol2qm74 3665 8 kDa kDa NNP cord-015021-pol2qm74 3665 9 TNF TNF NNP cord-015021-pol2qm74 3665 10 receptor receptor NN cord-015021-pol2qm74 3665 11 ( ( -LRB- cord-015021-pol2qm74 3665 12 sTNFRI sTNFRI NNP cord-015021-pol2qm74 3665 13 ) ) -RRB- cord-015021-pol2qm74 3665 14 and and CC cord-015021-pol2qm74 3665 15 the the DT cord-015021-pol2qm74 3665 16 75 75 CD cord-015021-pol2qm74 3665 17 kDa kDa NNP cord-015021-pol2qm74 3665 18 receptor receptor NN cord-015021-pol2qm74 3665 19 ( ( -LRB- cord-015021-pol2qm74 3665 20 sTNFRII sTNFRII NNP cord-015021-pol2qm74 3665 21 ) ) -RRB- cord-015021-pol2qm74 3665 22 are be VBP cord-015021-pol2qm74 3665 23 detectable detectable JJ cord-015021-pol2qm74 3665 24 in in IN cord-015021-pol2qm74 3665 25 the the DT cord-015021-pol2qm74 3665 26 circulation circulation NN cord-015021-pol2qm74 3665 27 . . . cord-015021-pol2qm74 3666 1 The the DT cord-015021-pol2qm74 3666 2 kinetics kinetic NNS cord-015021-pol2qm74 3666 3 of of IN cord-015021-pol2qm74 3666 4 these these DT cord-015021-pol2qm74 3666 5 endogenously endogenously RB cord-015021-pol2qm74 3666 6 produced produce VBN cord-015021-pol2qm74 3666 7 TNF TNF NNP cord-015021-pol2qm74 3666 8 - - HYPH cord-015021-pol2qm74 3666 9 inhibitors inhibitor NNS cord-015021-pol2qm74 3666 10 were be VBD cord-015021-pol2qm74 3666 11 measured measure VBN cord-015021-pol2qm74 3666 12 to to TO cord-015021-pol2qm74 3666 13 evaluate evaluate VB cord-015021-pol2qm74 3666 14 their -PRON- PRP$ cord-015021-pol2qm74 3666 15 role role NN cord-015021-pol2qm74 3666 16 in in IN cord-015021-pol2qm74 3666 17 patients patient NNS cord-015021-pol2qm74 3666 18 with with IN cord-015021-pol2qm74 3666 19 SIRS SIRS NNP cord-015021-pol2qm74 3666 20 . . . cord-015021-pol2qm74 3667 1 Fourteen fourteen CD cord-015021-pol2qm74 3667 2 patients patient NNS cord-015021-pol2qm74 3667 3 of of IN cord-015021-pol2qm74 3667 4 an an DT cord-015021-pol2qm74 3667 5 operative operative JJ cord-015021-pol2qm74 3667 6 ICU ICU NNP cord-015021-pol2qm74 3667 7 were be VBD cord-015021-pol2qm74 3667 8 included include VBN cord-015021-pol2qm74 3667 9 with with IN cord-015021-pol2qm74 3667 10 the the DT cord-015021-pol2qm74 3667 11 diagnossis diagnossis NN cord-015021-pol2qm74 3667 12 of of IN cord-015021-pol2qm74 3667 13 SIRS SIRS NNP cord-015021-pol2qm74 3667 14 ( ( -LRB- cord-015021-pol2qm74 3667 15 mean mean VB cord-015021-pol2qm74 3667 16 APACHE APACHE NNP cord-015021-pol2qm74 3667 17 II II NNP cord-015021-pol2qm74 3667 18 score score NN cord-015021-pol2qm74 3667 19 : : : cord-015021-pol2qm74 3667 20 20 20 CD cord-015021-pol2qm74 3667 21 points point NNS cord-015021-pol2qm74 3667 22 ) ) -RRB- cord-015021-pol2qm74 3667 23 . . . cord-015021-pol2qm74 3668 1 Serial serial JJ cord-015021-pol2qm74 3668 2 blood blood NN cord-015021-pol2qm74 3668 3 samples sample NNS cord-015021-pol2qm74 3668 4 were be VBD cord-015021-pol2qm74 3668 5 obtained obtain VBN cord-015021-pol2qm74 3668 6 within within IN cord-015021-pol2qm74 3668 7 12 12 CD cord-015021-pol2qm74 3668 8 h h NN cord-015021-pol2qm74 3668 9 after after IN cord-015021-pol2qm74 3668 10 diagnosis diagnosis NN cord-015021-pol2qm74 3668 11 of of IN cord-015021-pol2qm74 3668 12 SIRS SIRS NNP cord-015021-pol2qm74 3668 13 , , , cord-015021-pol2qm74 3668 14 every every DT cord-015021-pol2qm74 3668 15 6 6 CD cord-015021-pol2qm74 3668 16 hrs hrs NN cord-015021-pol2qm74 3668 17 for for IN cord-015021-pol2qm74 3668 18 the the DT cord-015021-pol2qm74 3668 19 first first JJ cord-015021-pol2qm74 3668 20 48 48 CD cord-015021-pol2qm74 3668 21 hrs hrs NN cord-015021-pol2qm74 3668 22 and and CC cord-015021-pol2qm74 3668 23 every every DT cord-015021-pol2qm74 3668 24 12 12 CD cord-015021-pol2qm74 3668 25 hrs hrs NN cord-015021-pol2qm74 3668 26 thereafter thereafter RB cord-015021-pol2qm74 3668 27 until until IN cord-015021-pol2qm74 3668 28 patients patient NNS cord-015021-pol2qm74 3668 29 died die VBD cord-015021-pol2qm74 3668 30 or or CC cord-015021-pol2qm74 3668 31 recovered recover VBD cord-015021-pol2qm74 3668 32 . . . cord-015021-pol2qm74 3669 1 Soluble soluble JJ cord-015021-pol2qm74 3669 2 TNFRI TNFRI NNP cord-015021-pol2qm74 3669 3 and and CC cord-015021-pol2qm74 3669 4 sTNFRII sTNFRII NNP cord-015021-pol2qm74 3669 5 were be VBD cord-015021-pol2qm74 3669 6 assayed assay VBN cord-015021-pol2qm74 3669 7 by by IN cord-015021-pol2qm74 3669 8 an an DT cord-015021-pol2qm74 3669 9 enzymed enzyme VBN cord-015021-pol2qm74 3669 10 - - HYPH cord-015021-pol2qm74 3669 11 linked link VBN cord-015021-pol2qm74 3669 12 immunological immunological JJ cord-015021-pol2qm74 3669 13 binding binding NN cord-015021-pol2qm74 3669 14 assay assay NN cord-015021-pol2qm74 3669 15 . . . cord-015021-pol2qm74 3670 1 Soluble soluble JJ cord-015021-pol2qm74 3670 2 TNFRI TNFRI NNP cord-015021-pol2qm74 3670 3 and and CC cord-015021-pol2qm74 3670 4 II II NNP cord-015021-pol2qm74 3670 5 could could MD cord-015021-pol2qm74 3670 6 be be VB cord-015021-pol2qm74 3670 7 detected detect VBN cord-015021-pol2qm74 3670 8 in in IN cord-015021-pol2qm74 3670 9 all all DT cord-015021-pol2qm74 3670 10 samples sample NNS cord-015021-pol2qm74 3670 11 with with IN cord-015021-pol2qm74 3670 12 a a DT cord-015021-pol2qm74 3670 13 significantly significantly RB cord-015021-pol2qm74 3670 14 higher high JJR cord-015021-pol2qm74 3670 15 level level NN cord-015021-pol2qm74 3670 16 ( ( -LRB- cord-015021-pol2qm74 3670 17 p p NN cord-015021-pol2qm74 3670 18 < < XX cord-015021-pol2qm74 3670 19 O o UH cord-015021-pol2qm74 3670 20 , , , cord-015021-pol2qm74 3670 21 O01 O01 NNP cord-015021-pol2qm74 3670 22 ) ) -RRB- cord-015021-pol2qm74 3670 23 compared compare VBD cord-015021-pol2qm74 3670 24 to to IN cord-015021-pol2qm74 3670 25 healthy healthy JJ cord-015021-pol2qm74 3670 26 controls control NNS cord-015021-pol2qm74 3670 27 ( ( -LRB- cord-015021-pol2qm74 3670 28 normal normal JJ cord-015021-pol2qm74 3670 29 value value NN cord-015021-pol2qm74 3670 30 : : : cord-015021-pol2qm74 3670 31 TNFRh TNFRh NNP cord-015021-pol2qm74 3670 32 1,5 1,5 CD cord-015021-pol2qm74 3670 33 ng ng NN cord-015021-pol2qm74 3670 34 / / SYM cord-015021-pol2qm74 3670 35 ml ml XX cord-015021-pol2qm74 3670 36 ; ; : cord-015021-pol2qm74 3670 37 TNFRII TNFRII NNP cord-015021-pol2qm74 3670 38 : : : cord-015021-pol2qm74 3670 39 2,3 2,3 CD cord-015021-pol2qm74 3670 40 ng ng NNP cord-015021-pol2qm74 3670 41 / / SYM cord-015021-pol2qm74 3670 42 ml ml NN cord-015021-pol2qm74 3670 43 ) ) -RRB- cord-015021-pol2qm74 3670 44 . . . cord-015021-pol2qm74 3671 1 The the DT cord-015021-pol2qm74 3671 2 serum serum NN cord-015021-pol2qm74 3671 3 concentration concentration NN cord-015021-pol2qm74 3671 4 of of IN cord-015021-pol2qm74 3671 5 TNFRI TNFRI NNP cord-015021-pol2qm74 3672 1 ( ( -LRB- cord-015021-pol2qm74 3672 2 14,1 14,1 CD cord-015021-pol2qm74 3672 3 ng ng NNP cord-015021-pol2qm74 3672 4 / / SYM cord-015021-pol2qm74 3672 5 ml ml NNP cord-015021-pol2qm74 3672 6 ) ) -RRB- cord-015021-pol2qm74 3672 7 as as RB cord-015021-pol2qm74 3672 8 well well RB cord-015021-pol2qm74 3672 9 as as IN cord-015021-pol2qm74 3672 10 TNFRII TNFRII NNP cord-015021-pol2qm74 3672 11 ( ( -LRB- cord-015021-pol2qm74 3672 12 18,2 18,2 CD cord-015021-pol2qm74 3672 13 ng ng NNP cord-015021-pol2qm74 3672 14 / / SYM cord-015021-pol2qm74 3672 15 ml ml NN cord-015021-pol2qm74 3672 16 ) ) -RRB- cord-015021-pol2qm74 3672 17 were be VBD cord-015021-pol2qm74 3672 18 significantly significantly RB cord-015021-pol2qm74 3672 19 higher high JJR cord-015021-pol2qm74 3672 20 in in IN cord-015021-pol2qm74 3672 21 nonsurvivors nonsurvivors NNP cord-015021-pol2qm74 3672 22 ( ( -LRB- cord-015021-pol2qm74 3672 23 n=6 n=6 NNP cord-015021-pol2qm74 3672 24 ) ) -RRB- cord-015021-pol2qm74 3672 25 compared compare VBN cord-015021-pol2qm74 3672 26 to to IN cord-015021-pol2qm74 3672 27 survivors survivor NNS cord-015021-pol2qm74 3672 28 ( ( -LRB- cord-015021-pol2qm74 3672 29 8,6 8,6 CD cord-015021-pol2qm74 3672 30 and and CC cord-015021-pol2qm74 3672 31 9,5 9,5 CD cord-015021-pol2qm74 3672 32 ng ng NN cord-015021-pol2qm74 3672 33 / / SYM cord-015021-pol2qm74 3672 34 ml ml NN cord-015021-pol2qm74 3672 35 ; ; : cord-015021-pol2qm74 3672 36 n=8 n=8 NN cord-015021-pol2qm74 3672 37 ) ) -RRB- cord-015021-pol2qm74 3672 38 at at IN cord-015021-pol2qm74 3672 39 the the DT cord-015021-pol2qm74 3672 40 onset onset NN cord-015021-pol2qm74 3672 41 of of IN cord-015021-pol2qm74 3672 42 SIRS SIRS NNP cord-015021-pol2qm74 3672 43 and and CC cord-015021-pol2qm74 3672 44 during during IN cord-015021-pol2qm74 3672 45 the the DT cord-015021-pol2qm74 3672 46 course course NN cord-015021-pol2qm74 3672 47 of of IN cord-015021-pol2qm74 3672 48 the the DT cord-015021-pol2qm74 3672 49 inflammation inflammation NN cord-015021-pol2qm74 3672 50 response response NN cord-015021-pol2qm74 3672 51 ( ( -LRB- cord-015021-pol2qm74 3672 52 p<0,05 p<0,05 NNP cord-015021-pol2qm74 3672 53 ) ) -RRB- cord-015021-pol2qm74 3672 54 . . . cord-015021-pol2qm74 3673 1 A a DT cord-015021-pol2qm74 3673 2 positive positive JJ cord-015021-pol2qm74 3673 3 correlation correlation NN cord-015021-pol2qm74 3673 4 exists exist VBZ cord-015021-pol2qm74 3673 5 between between IN cord-015021-pol2qm74 3673 6 both both DT cord-015021-pol2qm74 3673 7 receptors receptor NNS cord-015021-pol2qm74 3673 8 ( ( -LRB- cord-015021-pol2qm74 3674 1 r-0,57 r-0,57 NNP cord-015021-pol2qm74 3674 2 ; ; : cord-015021-pol2qm74 3674 3 p p NN cord-015021-pol2qm74 3674 4 < < XX cord-015021-pol2qm74 3674 5 0,01 0,01 NN cord-015021-pol2qm74 3674 6 ) ) -RRB- cord-015021-pol2qm74 3674 7 . . . cord-015021-pol2qm74 3675 1 Increasing increase VBG cord-015021-pol2qm74 3675 2 levels level NNS cord-015021-pol2qm74 3675 3 and and CC cord-015021-pol2qm74 3675 4 maximal maximal JJ cord-015021-pol2qm74 3675 5 values value NNS cord-015021-pol2qm74 3675 6 of of IN cord-015021-pol2qm74 3675 7 sTNFRI stnfri JJ cord-015021-pol2qm74 3675 8 ( ( -LRB- cord-015021-pol2qm74 3675 9 59 59 CD cord-015021-pol2qm74 3675 10 ng ng NNP cord-015021-pol2qm74 3675 11 / / SYM cord-015021-pol2qm74 3675 12 ml ml NN cord-015021-pol2qm74 3675 13 ) ) -RRB- cord-015021-pol2qm74 3675 14 and and CC cord-015021-pol2qm74 3675 15 I1 i1 NN cord-015021-pol2qm74 3675 16 ( ( -LRB- cord-015021-pol2qm74 3675 17 82 82 CD cord-015021-pol2qm74 3675 18 ng ng NNP cord-015021-pol2qm74 3675 19 / / SYM cord-015021-pol2qm74 3675 20 mI mI NNP cord-015021-pol2qm74 3675 21 ) ) -RRB- cord-015021-pol2qm74 3675 22 were be VBD cord-015021-pol2qm74 3675 23 detected detect VBN cord-015021-pol2qm74 3675 24 only only RB cord-015021-pol2qm74 3675 25 in in IN cord-015021-pol2qm74 3675 26 patients patient NNS cord-015021-pol2qm74 3675 27 who who WP cord-015021-pol2qm74 3675 28 died die VBD cord-015021-pol2qm74 3675 29 . . . cord-015021-pol2qm74 3676 1 The the DT cord-015021-pol2qm74 3676 2 serum serum NN cord-015021-pol2qm74 3676 3 concentrations concentration NNS cord-015021-pol2qm74 3676 4 of of IN cord-015021-pol2qm74 3676 5 patients patient NNS cord-015021-pol2qm74 3676 6 who who WP cord-015021-pol2qm74 3676 7 recovered recover VBD cord-015021-pol2qm74 3676 8 did do VBD cord-015021-pol2qm74 3676 9 not not RB cord-015021-pol2qm74 3676 10 change change VB cord-015021-pol2qm74 3676 11 and and CC cord-015021-pol2qm74 3676 12 are be VBP cord-015021-pol2qm74 3676 13 remaining remain VBG cord-015021-pol2qm74 3676 14 at at IN cord-015021-pol2qm74 3676 15 the the DT cord-015021-pol2qm74 3676 16 initial initial JJ cord-015021-pol2qm74 3676 17 level level NN cord-015021-pol2qm74 3676 18 . . . cord-015021-pol2qm74 3677 1 TNF TNF NNP cord-015021-pol2qm74 3677 2 alpha alpha NN cord-015021-pol2qm74 3677 3 bioactivity bioactivity NN cord-015021-pol2qm74 3677 4 was be VBD cord-015021-pol2qm74 3677 5 detected detect VBN cord-015021-pol2qm74 3677 6 in in IN cord-015021-pol2qm74 3677 7 10 10 CD cord-015021-pol2qm74 3677 8 out out IN cord-015021-pol2qm74 3677 9 of of IN cord-015021-pol2qm74 3677 10 14 14 CD cord-015021-pol2qm74 3677 11 patients patient NNS cord-015021-pol2qm74 3677 12 . . . cord-015021-pol2qm74 3678 1 No no DT cord-015021-pol2qm74 3678 2 significant significant JJ cord-015021-pol2qm74 3678 3 correlation correlation NN cord-015021-pol2qm74 3678 4 exists exist VBZ cord-015021-pol2qm74 3678 5 between between IN cord-015021-pol2qm74 3678 6 the the DT cord-015021-pol2qm74 3678 7 concentration concentration NN cord-015021-pol2qm74 3678 8 of of IN cord-015021-pol2qm74 3678 9 both both DT cord-015021-pol2qm74 3678 10 receptors receptor NNS cord-015021-pol2qm74 3678 11 and and CC cord-015021-pol2qm74 3678 12 TNF TNF NNP cord-015021-pol2qm74 3678 13 alpha alpha NN cord-015021-pol2qm74 3678 14 as as RB cord-015021-pol2qm74 3678 15 well well RB cord-015021-pol2qm74 3678 16 as as IN cord-015021-pol2qm74 3678 17 the the DT cord-015021-pol2qm74 3678 18 APACHE APACHE NNP cord-015021-pol2qm74 3678 19 II II NNP cord-015021-pol2qm74 3678 20 score score NN cord-015021-pol2qm74 3678 21 at at IN cord-015021-pol2qm74 3678 22 the the DT cord-015021-pol2qm74 3678 23 onset onset NN cord-015021-pol2qm74 3678 24 of of IN cord-015021-pol2qm74 3678 25 SIRS SIRS NNP cord-015021-pol2qm74 3678 26 . . . cord-015021-pol2qm74 3679 1 Elevated elevated JJ cord-015021-pol2qm74 3679 2 serum serum NN cord-015021-pol2qm74 3679 3 concentration concentration NN cord-015021-pol2qm74 3679 4 of of IN cord-015021-pol2qm74 3679 5 sTNFRI stnfri JJ cord-015021-pol2qm74 3679 6 and and CC cord-015021-pol2qm74 3679 7 11 11 CD cord-015021-pol2qm74 3679 8 are be VBP cord-015021-pol2qm74 3679 9 found find VBN cord-015021-pol2qm74 3679 10 in in IN cord-015021-pol2qm74 3679 11 patients patient NNS cord-015021-pol2qm74 3679 12 with with IN cord-015021-pol2qm74 3679 13 SIRS SIRS NNP cord-015021-pol2qm74 3679 14 . . . cord-015021-pol2qm74 3680 1 These these DT cord-015021-pol2qm74 3680 2 naturally naturally RB cord-015021-pol2qm74 3680 3 occuring occur VBG cord-015021-pol2qm74 3680 4 antagonists antagonist NNS cord-015021-pol2qm74 3680 5 reflect reflect VBP cord-015021-pol2qm74 3680 6 the the DT cord-015021-pol2qm74 3680 7 inflammatory inflammatory JJ cord-015021-pol2qm74 3680 8 process process NN cord-015021-pol2qm74 3680 9 . . . cord-015021-pol2qm74 3681 1 The the DT cord-015021-pol2qm74 3681 2 measurement measurement NN cord-015021-pol2qm74 3681 3 of of IN cord-015021-pol2qm74 3681 4 soluble soluble JJ cord-015021-pol2qm74 3681 5 TNF TNF NNP cord-015021-pol2qm74 3681 6 receptor receptor NN cord-015021-pol2qm74 3681 7 levels level NNS cord-015021-pol2qm74 3681 8 may may MD cord-015021-pol2qm74 3681 9 be be VB cord-015021-pol2qm74 3681 10 useful useful JJ cord-015021-pol2qm74 3681 11 in in IN cord-015021-pol2qm74 3681 12 monitorina monitorina JJ cord-015021-pol2qm74 3681 13 SIRS SIRS NNP cord-015021-pol2qm74 3681 14 and and CC cord-015021-pol2qm74 3681 15 in in IN cord-015021-pol2qm74 3681 16 the the DT cord-015021-pol2qm74 3681 17 prediction prediction NN cord-015021-pol2qm74 3681 18 of of IN cord-015021-pol2qm74 3681 19 outcome outcome NN cord-015021-pol2qm74 3681 20 . . . cord-015021-pol2qm74 3682 1 11 11 CD cord-015021-pol2qm74 3682 2 - - SYM cord-015021-pol2qm74 3682 3 2 2 CD cord-015021-pol2qm74 3682 4 is be VBZ cord-015021-pol2qm74 3682 5 given give VBN cord-015021-pol2qm74 3682 6 to to IN cord-015021-pol2qm74 3682 7 patients patient NNS cord-015021-pol2qm74 3682 8 with with IN cord-015021-pol2qm74 3682 9 advanced advanced JJ cord-015021-pol2qm74 3682 10 melanoma melanoma NN cord-015021-pol2qm74 3682 11 or or CC cord-015021-pol2qm74 3682 12 renal renal JJ cord-015021-pol2qm74 3682 13 carcinoma carcinoma NN cord-015021-pol2qm74 3682 14 . . . cord-015021-pol2qm74 3683 1 However however RB cord-015021-pol2qm74 3683 2 , , , cord-015021-pol2qm74 3683 3 this this DT cord-015021-pol2qm74 3683 4 therapy therapy NN cord-015021-pol2qm74 3683 5 is be VBZ cord-015021-pol2qm74 3683 6 accompanied accompany VBN cord-015021-pol2qm74 3683 7 by by IN cord-015021-pol2qm74 3683 8 severe severe JJ cord-015021-pol2qm74 3683 9 side side NN cord-015021-pol2qm74 3683 10 effects effect NNS cord-015021-pol2qm74 3683 11 , , , cord-015021-pol2qm74 3683 12 including include VBG cord-015021-pol2qm74 3683 13 the the DT cord-015021-pol2qm74 3683 14 Vascular vascular JJ cord-015021-pol2qm74 3683 15 Leak Leak NNP cord-015021-pol2qm74 3683 16 Syndrome syndrome NN cord-015021-pol2qm74 3683 17 ( ( -LRB- cord-015021-pol2qm74 3683 18 VLS VLS NNP cord-015021-pol2qm74 3683 19 ) ) -RRB- cord-015021-pol2qm74 3683 20 that that WDT cord-015021-pol2qm74 3683 21 closely closely RB cord-015021-pol2qm74 3683 22 resembles resemble VBZ cord-015021-pol2qm74 3683 23 septic septic JJ cord-015021-pol2qm74 3683 24 shock shock NN cord-015021-pol2qm74 3683 25 . . . cord-015021-pol2qm74 3684 1 To to TO cord-015021-pol2qm74 3684 2 investigate investigate VB cord-015021-pol2qm74 3684 3 the the DT cord-015021-pol2qm74 3684 4 involvement involvement NN cord-015021-pol2qm74 3684 5 of of IN cord-015021-pol2qm74 3684 6 cytokines cytokine NNS cord-015021-pol2qm74 3684 7 and and CC cord-015021-pol2qm74 3684 8 phospholipase phospholipase NN cord-015021-pol2qm74 3684 9 A a DT cord-015021-pol2qm74 3684 10 z z NN cord-015021-pol2qm74 3684 11 in in IN cord-015021-pol2qm74 3684 12 the the DT cord-015021-pol2qm74 3684 13 pathogenesis pathogenesis NN cord-015021-pol2qm74 3684 14 of of IN cord-015021-pol2qm74 3684 15 the the DT cord-015021-pol2qm74 3684 16 VLS vls NN cord-015021-pol2qm74 3684 17 we -PRON- PRP cord-015021-pol2qm74 3684 18 collected collect VBD cord-015021-pol2qm74 3684 19 serial serial JJ cord-015021-pol2qm74 3684 20 plasma plasma NN cord-015021-pol2qm74 3684 21 samples sample NNS cord-015021-pol2qm74 3684 22 from from IN cord-015021-pol2qm74 3684 23 patients patient NNS cord-015021-pol2qm74 3684 24 during during IN cord-015021-pol2qm74 3684 25 the the DT cord-015021-pol2qm74 3684 26 first first JJ cord-015021-pol2qm74 3684 27 24 24 CD cord-015021-pol2qm74 3684 28 hours hour NNS cord-015021-pol2qm74 3684 29 after after IN cord-015021-pol2qm74 3684 30 administration administration NN cord-015021-pol2qm74 3684 31 of of IN cord-015021-pol2qm74 3684 32 IL-2 IL-2 NNP cord-015021-pol2qm74 3684 33 . . . cord-015021-pol2qm74 3685 1 In in IN cord-015021-pol2qm74 3685 2 these these DT cord-015021-pol2qm74 3685 3 patients patient NNS cord-015021-pol2qm74 3685 4 we -PRON- PRP cord-015021-pol2qm74 3685 5 monitored monitor VBD cord-015021-pol2qm74 3685 6 temperature temperature NN cord-015021-pol2qm74 3685 7 , , , cord-015021-pol2qm74 3685 8 blood blood NN cord-015021-pol2qm74 3685 9 pressure pressure NN cord-015021-pol2qm74 3685 10 and and CC cord-015021-pol2qm74 3685 11 heart heart NN cord-015021-pol2qm74 3685 12 rate rate NN cord-015021-pol2qm74 3685 13 and and CC cord-015021-pol2qm74 3685 14 assessed assess VBN cord-015021-pol2qm74 3685 15 levels level NNS cord-015021-pol2qm74 3685 16 of of IN cord-015021-pol2qm74 3685 17 the the DT cord-015021-pol2qm74 3685 18 cytokines cytokine NNS cord-015021-pol2qm74 3685 19 TNF TNF NNP cord-015021-pol2qm74 3685 20 , , , cord-015021-pol2qm74 3685 21 IL-6 IL-6 NNP cord-015021-pol2qm74 3685 22 and and CC cord-015021-pol2qm74 3685 23 IL-8 IL-8 NNP cord-015021-pol2qm74 3685 24 using use VBG cord-015021-pol2qm74 3685 25 immuno immuno JJ cord-015021-pol2qm74 3685 26 assays assay NNS cord-015021-pol2qm74 3685 27 . . . cord-015021-pol2qm74 3686 1 In in IN cord-015021-pol2qm74 3686 2 these these DT cord-015021-pol2qm74 3686 3 plasma plasma NN cord-015021-pol2qm74 3686 4 samples sample NNS cord-015021-pol2qm74 3686 5 we -PRON- PRP cord-015021-pol2qm74 3686 6 also also RB cord-015021-pol2qm74 3686 7 measured measure VBD cord-015021-pol2qm74 3686 8 phospholipase phospholipase NN cord-015021-pol2qm74 3687 1 A a DT cord-015021-pol2qm74 3687 2 2 2 CD cord-015021-pol2qm74 3687 3 activity activity NN cord-015021-pol2qm74 3687 4 using use VBG cord-015021-pol2qm74 3687 5 an an DT cord-015021-pol2qm74 3687 6 enzyme enzyme NN cord-015021-pol2qm74 3687 7 activity activity NN cord-015021-pol2qm74 3687 8 assay assay NN cord-015021-pol2qm74 3687 9 , , , cord-015021-pol2qm74 3687 10 since since IN cord-015021-pol2qm74 3687 11 this this DT cord-015021-pol2qm74 3687 12 enzyme enzyme NN cord-015021-pol2qm74 3687 13 is be VBZ cord-015021-pol2qm74 3687 14 beleived beleive VBN cord-015021-pol2qm74 3687 15 to to TO cord-015021-pol2qm74 3687 16 play play VB cord-015021-pol2qm74 3687 17 a a DT cord-015021-pol2qm74 3687 18 major major JJ cord-015021-pol2qm74 3687 19 role role NN cord-015021-pol2qm74 3687 20 in in IN cord-015021-pol2qm74 3687 21 the the DT cord-015021-pol2qm74 3687 22 generation generation NN cord-015021-pol2qm74 3687 23 of of IN cord-015021-pol2qm74 3687 24 lipid lipid NN cord-015021-pol2qm74 3687 25 mediators mediator NNS cord-015021-pol2qm74 3687 26 . . . cord-015021-pol2qm74 3688 1 We -PRON- PRP cord-015021-pol2qm74 3688 2 demonstrate demonstrate VBP cord-015021-pol2qm74 3688 3 that that IN cord-015021-pol2qm74 3688 4 during during IN cord-015021-pol2qm74 3688 5 IL-2 IL-2 NNP cord-015021-pol2qm74 3688 6 therapy therapy NN cord-015021-pol2qm74 3688 7 the the DT cord-015021-pol2qm74 3688 8 cytokines cytokine NNS cord-015021-pol2qm74 3688 9 TNF TNF NNP cord-015021-pol2qm74 3688 10 , , , cord-015021-pol2qm74 3688 11 IL-6 IL-6 NNP cord-015021-pol2qm74 3688 12 , , , cord-015021-pol2qm74 3688 13 and and CC cord-015021-pol2qm74 3688 14 IL-8 IL-8 NNP cord-015021-pol2qm74 3688 15 are be VBP cord-015021-pol2qm74 3688 16 produced produce VBN cord-015021-pol2qm74 3688 17 and and CC cord-015021-pol2qm74 3688 18 that that IN cord-015021-pol2qm74 3688 19 the the DT cord-015021-pol2qm74 3688 20 release release NN cord-015021-pol2qm74 3688 21 of of IN cord-015021-pol2qm74 3688 22 these these DT cord-015021-pol2qm74 3688 23 cytokines cytokine NNS cord-015021-pol2qm74 3688 24 is be VBZ cord-015021-pol2qm74 3688 25 followed follow VBN cord-015021-pol2qm74 3688 26 by by IN cord-015021-pol2qm74 3688 27 an an DT cord-015021-pol2qm74 3688 28 induction induction NN cord-015021-pol2qm74 3688 29 of of IN cord-015021-pol2qm74 3688 30 phospholipase phospholipase NN cord-015021-pol2qm74 3688 31 Az Az NNP cord-015021-pol2qm74 3688 32 activity activity NN cord-015021-pol2qm74 3688 33 in in IN cord-015021-pol2qm74 3688 34 the the DT cord-015021-pol2qm74 3688 35 plasma plasma NN cord-015021-pol2qm74 3688 36 of of IN cord-015021-pol2qm74 3688 37 these these DT cord-015021-pol2qm74 3688 38 patients patient NNS cord-015021-pol2qm74 3688 39 , , , cord-015021-pol2qm74 3688 40 We -PRON- PRP cord-015021-pol2qm74 3688 41 further further RB cord-015021-pol2qm74 3688 42 discuss discuss VBP cord-015021-pol2qm74 3688 43 the the DT cord-015021-pol2qm74 3688 44 role role NN cord-015021-pol2qm74 3688 45 of of IN cord-015021-pol2qm74 3688 46 these these DT cord-015021-pol2qm74 3688 47 mediators mediator NNS cord-015021-pol2qm74 3688 48 in in IN cord-015021-pol2qm74 3688 49 the the DT cord-015021-pol2qm74 3688 50 development development NN cord-015021-pol2qm74 3688 51 of of IN cord-015021-pol2qm74 3688 52 the the DT cord-015021-pol2qm74 3688 53 vascular vascular JJ cord-015021-pol2qm74 3688 54 leak leak NN cord-015021-pol2qm74 3688 55 syndrome syndrome NN cord-015021-pol2qm74 3688 56 observed observe VBN cord-015021-pol2qm74 3688 57 in in IN cord-015021-pol2qm74 3688 58 patients patient NNS cord-015021-pol2qm74 3688 59 receiving receive VBG cord-015021-pol2qm74 3688 60 IL-2 IL-2 NNP cord-015021-pol2qm74 3688 61 . . . cord-015021-pol2qm74 3689 1 Objectives objective NNS cord-015021-pol2qm74 3689 2 of of IN cord-015021-pol2qm74 3689 3 the the DT cord-015021-pol2qm74 3689 4 study study NN cord-015021-pol2qm74 3689 5 : : : cord-015021-pol2qm74 3689 6 Sepsis sepsis NN cord-015021-pol2qm74 3689 7 caused cause VBN cord-015021-pol2qm74 3689 8 by by IN cord-015021-pol2qm74 3689 9 Candida Candida NNP cord-015021-pol2qm74 3689 10 albicans albican NNS cord-015021-pol2qm74 3689 11 ( ( -LRB- cord-015021-pol2qm74 3689 12 CA CA NNP cord-015021-pol2qm74 3689 13 ) ) -RRB- cord-015021-pol2qm74 3689 14 is be VBZ cord-015021-pol2qm74 3689 15 no no RB cord-015021-pol2qm74 3689 16 longer long RBR cord-015021-pol2qm74 3689 17 a a DT cord-015021-pol2qm74 3689 18 clinical clinical JJ cord-015021-pol2qm74 3689 19 rarity rarity NN cord-015021-pol2qm74 3689 20 but but CC cord-015021-pol2qm74 3689 21 a a DT cord-015021-pol2qm74 3689 22 common common JJ cord-015021-pol2qm74 3689 23 consequence consequence NN cord-015021-pol2qm74 3689 24 of of IN cord-015021-pol2qm74 3689 25 immunosuppression immunosuppression NN cord-015021-pol2qm74 3689 26 and and CC cord-015021-pol2qm74 3689 27 surgery surgery NN cord-015021-pol2qm74 3689 28 , , , cord-015021-pol2qm74 3689 29 and and CC cord-015021-pol2qm74 3689 30 is be VBZ cord-015021-pol2qm74 3689 31 associated associate VBN cord-015021-pol2qm74 3689 32 with with IN cord-015021-pol2qm74 3689 33 high high JJ cord-015021-pol2qm74 3689 34 mortality mortality NN cord-015021-pol2qm74 3689 35 . . . cord-015021-pol2qm74 3690 1 Tumor tumor NN cord-015021-pol2qm74 3690 2 necrosis necrosis NN cord-015021-pol2qm74 3690 3 faetor faetor NN cord-015021-pol2qm74 3690 4 - - HYPH cord-015021-pol2qm74 3690 5 c¢ c¢ NNP cord-015021-pol2qm74 3690 6 ( ( -LRB- cord-015021-pol2qm74 3690 7 TNF-<~ tnf-<~ NN cord-015021-pol2qm74 3690 8 ) ) -RRB- cord-015021-pol2qm74 3691 1 , , , cord-015021-pol2qm74 3691 2 interlcukin interlcukin NNP cord-015021-pol2qm74 3691 3 - - HYPH cord-015021-pol2qm74 3691 4 lg lg NNP cord-015021-pol2qm74 3691 5 ( ( -LRB- cord-015021-pol2qm74 3691 6 IL IL NNP cord-015021-pol2qm74 3691 7 - - HYPH cord-015021-pol2qm74 3691 8 lg lg NNP cord-015021-pol2qm74 3691 9 ) ) -RRB- cord-015021-pol2qm74 3691 10 and and CC cord-015021-pol2qm74 3691 11 interleukin-6 interleukin-6 NNP cord-015021-pol2qm74 3691 12 ( ( -LRB- cord-015021-pol2qm74 3691 13 IL-6 IL-6 NNP cord-015021-pol2qm74 3691 14 ) ) -RRB- cord-015021-pol2qm74 3691 15 are be VBP cord-015021-pol2qm74 3691 16 thought think VBN cord-015021-pol2qm74 3691 17 to to TO cord-015021-pol2qm74 3691 18 play play VB cord-015021-pol2qm74 3691 19 an an DT cord-015021-pol2qm74 3691 20 important important JJ cord-015021-pol2qm74 3691 21 role role NN cord-015021-pol2qm74 3691 22 in in IN cord-015021-pol2qm74 3691 23 the the DT cord-015021-pol2qm74 3691 24 pathogenesis pathogenesis NN cord-015021-pol2qm74 3691 25 of of IN cord-015021-pol2qm74 3691 26 the the DT cord-015021-pol2qm74 3691 27 sepsis sepsis NN cord-015021-pol2qm74 3691 28 syndrome syndrome NN cord-015021-pol2qm74 3691 29 . . . cord-015021-pol2qm74 3692 1 We -PRON- PRP cord-015021-pol2qm74 3692 2 therefore therefore RB cord-015021-pol2qm74 3692 3 studied study VBD cord-015021-pol2qm74 3692 4 the the DT cord-015021-pol2qm74 3692 5 in in FW cord-015021-pol2qm74 3692 6 vitro vitro FW cord-015021-pol2qm74 3692 7 production production NN cord-015021-pol2qm74 3692 8 of of IN cord-015021-pol2qm74 3692 9 TNF- > NFP cord-015021-pol2qm74 4116 21 35 35 CD cord-015021-pol2qm74 4116 22 % % NN cord-015021-pol2qm74 4116 23 total total JJ cord-015021-pol2qm74 4116 24 body body NN cord-015021-pol2qm74 4116 25 surface surface NN cord-015021-pol2qm74 4116 26 area area NN cord-015021-pol2qm74 4116 27 ) ) -RRB- cord-015021-pol2qm74 4117 1 patients patient NNS cord-015021-pol2qm74 4117 2 exhibited exhibit VBD cord-015021-pol2qm74 4117 3 high high JJ cord-015021-pol2qm74 4117 4 levels level NNS cord-015021-pol2qm74 4117 5 of of IN cord-015021-pol2qm74 4117 6 constitutive constitutive JJ cord-015021-pol2qm74 4117 7 expression expression NN cord-015021-pol2qm74 4117 8 of of IN cord-015021-pol2qm74 4117 9 surface surface NN cord-015021-pol2qm74 4117 10 receptor receptor NN cord-015021-pol2qm74 4117 11 for for IN cord-015021-pol2qm74 4117 12 ] ] -RRB- cord-015021-pol2qm74 4117 13 L l NN cord-015021-pol2qm74 4117 14 2 2 CD cord-015021-pol2qm74 4117 15 ( ( -LRB- cord-015021-pol2qm74 4117 16 CD CD NNP cord-015021-pol2qm74 4117 17 25 25 CD cord-015021-pol2qm74 4117 18 ) ) -RRB- cord-015021-pol2qm74 4117 19 and and CC cord-015021-pol2qm74 4117 20 spontaneous spontaneous JJ cord-015021-pol2qm74 4117 21 blastogenesis blastogenesis NN cord-015021-pol2qm74 4117 22 . . . cord-015021-pol2qm74 4118 1 The the DT cord-015021-pol2qm74 4118 2 presence presence NN cord-015021-pol2qm74 4118 3 of of IN cord-015021-pol2qm74 4118 4 activation activation NN cord-015021-pol2qm74 4118 5 - - HYPH cord-015021-pol2qm74 4118 6 related relate VBN cord-015021-pol2qm74 4118 7 T t NN cord-015021-pol2qm74 4118 8 cellproducts cellproduct NNS cord-015021-pol2qm74 4118 9 in in IN cord-015021-pol2qm74 4118 10 bum bum NN cord-015021-pol2qm74 4118 11 plasma plasma NN cord-015021-pol2qm74 4118 12 was be VBD cord-015021-pol2qm74 4118 13 also also RB cord-015021-pol2qm74 4118 14 apparent apparent JJ cord-015021-pol2qm74 4118 15 . . . cord-015021-pol2qm74 4119 1 Subsequent subsequent JJ cord-015021-pol2qm74 4119 2 impairment impairment NN cord-015021-pol2qm74 4119 3 of of IN cord-015021-pol2qm74 4119 4 the the DT cord-015021-pol2qm74 4119 5 T T NNP cord-015021-pol2qm74 4119 6 cell cell NN cord-015021-pol2qm74 4119 7 receptor receptor NN cord-015021-pol2qm74 4119 8 ( ( -LRB- cord-015021-pol2qm74 4119 9 TCR)-regulated tcr)-regulate VBN cord-015021-pol2qm74 4119 10 T T NNP cord-015021-pol2qm74 4119 11 cell cell NN cord-015021-pol2qm74 4119 12 responses response NNS cord-015021-pol2qm74 4119 13 in in IN cord-015021-pol2qm74 4119 14 vitro vitro FW cord-015021-pol2qm74 4119 15 was be VBD cord-015021-pol2qm74 4119 16 accompanied accompany VBN cord-015021-pol2qm74 4119 17 by by IN cord-015021-pol2qm74 4119 18 significantly significantly RB cord-015021-pol2qm74 4119 19 increased increase VBN cord-015021-pol2qm74 4119 20 DNA dna NN cord-015021-pol2qm74 4119 21 fragmentation fragmentation NN cord-015021-pol2qm74 4119 22 that that WDT cord-015021-pol2qm74 4119 23 is be VBZ cord-015021-pol2qm74 4119 24 associated associate VBN cord-015021-pol2qm74 4119 25 with with IN cord-015021-pol2qm74 4119 26 cell cell NN cord-015021-pol2qm74 4119 27 death death NN cord-015021-pol2qm74 4119 28 by by IN cord-015021-pol2qm74 4119 29 the the DT cord-015021-pol2qm74 4119 30 mode mode NN cord-015021-pol2qm74 4119 31 of of IN cord-015021-pol2qm74 4119 32 apoptosis apoptosis NN cord-015021-pol2qm74 4119 33 . . . cord-015021-pol2qm74 4120 1 Using use VBG cord-015021-pol2qm74 4120 2 molecular molecular JJ cord-015021-pol2qm74 4120 3 markers marker NNS cord-015021-pol2qm74 4120 4 we -PRON- PRP cord-015021-pol2qm74 4120 5 established establish VBD cord-015021-pol2qm74 4120 6 that that IN cord-015021-pol2qm74 4120 7 flesh flesh NN cord-015021-pol2qm74 4120 8 peripheral peripheral JJ cord-015021-pol2qm74 4120 9 blood blood NN cord-015021-pol2qm74 4120 10 ceils ceil NNS cord-015021-pol2qm74 4120 11 from from IN cord-015021-pol2qm74 4120 12 immunosuppressed immunosuppressed JJ cord-015021-pol2qm74 4120 13 patients patient NNS cord-015021-pol2qm74 4120 14 also also RB cord-015021-pol2qm74 4120 15 contain contain VBP cord-015021-pol2qm74 4120 16 large large JJ cord-015021-pol2qm74 4120 17 numbers number NNS cord-015021-pol2qm74 4120 18 of of IN cord-015021-pol2qm74 4120 19 apoptotic apoptotic JJ cord-015021-pol2qm74 4120 20 cells cell NNS cord-015021-pol2qm74 4120 21 . . . cord-015021-pol2qm74 4121 1 Fluctuations fluctuation NNS cord-015021-pol2qm74 4121 2 in in IN cord-015021-pol2qm74 4121 3 the the DT cord-015021-pol2qm74 4121 4 number number NN cord-015021-pol2qm74 4121 5 of of IN cord-015021-pol2qm74 4121 6 viable viable JJ cord-015021-pol2qm74 4121 7 ( ( -LRB- cord-015021-pol2qm74 4121 8 PI- PI- NNP cord-015021-pol2qm74 4121 9 ) ) -RRB- cord-015021-pol2qm74 4121 10 peripheral peripheral JJ cord-015021-pol2qm74 4121 11 blood blood NN cord-015021-pol2qm74 4121 12 lymphocytes lymphocyte NNS cord-015021-pol2qm74 4121 13 involved involve VBN cord-015021-pol2qm74 4121 14 primarily primarily RB cord-015021-pol2qm74 4121 15 CD4+/CD45RO+ CD4+/CD45RO+ NNP cord-015021-pol2qm74 4121 16 ( ( -LRB- cord-015021-pol2qm74 4121 17 memory memory NN cord-015021-pol2qm74 4121 18 ) ) -RRB- cord-015021-pol2qm74 4121 19 subset subset NN cord-015021-pol2qm74 4121 20 of of IN cord-015021-pol2qm74 4121 21 T T NNP cord-015021-pol2qm74 4121 22 ceils ceil NNS cord-015021-pol2qm74 4121 23 . . . cord-015021-pol2qm74 4122 1 The the DT cord-015021-pol2qm74 4122 2 above above JJ cord-015021-pol2qm74 4122 3 observations observation NNS cord-015021-pol2qm74 4122 4 suggest suggest VBP cord-015021-pol2qm74 4122 5 that that IN cord-015021-pol2qm74 4122 6 thermal thermal JJ cord-015021-pol2qm74 4122 7 trauma trauma NN cord-015021-pol2qm74 4122 8 - - HYPH cord-015021-pol2qm74 4122 9 associated associate VBN cord-015021-pol2qm74 4122 10 T T NNP cord-015021-pol2qm74 4122 11 cell cell NN cord-015021-pol2qm74 4122 12 anergy anergy NN cord-015021-pol2qm74 4122 13 develops develop VBZ cord-015021-pol2qm74 4122 14 through through IN cord-015021-pol2qm74 4122 15 AICD AICD NNP cord-015021-pol2qm74 4122 16 , , , cord-015021-pol2qm74 4122 17 a a DT cord-015021-pol2qm74 4122 18 phenomenon phenomenon NN cord-015021-pol2qm74 4122 19 commonly commonly RB cord-015021-pol2qm74 4122 20 associated associate VBN cord-015021-pol2qm74 4122 21 with with IN cord-015021-pol2qm74 4122 22 the the DT cord-015021-pol2qm74 4122 23 tolerogenic tolerogenic JJ cord-015021-pol2qm74 4122 24 activity activity NN cord-015021-pol2qm74 4122 25 of of IN cord-015021-pol2qm74 4122 26 bacterial bacterial JJ cord-015021-pol2qm74 4122 27 superantigens superantigen NNS cord-015021-pol2qm74 4122 28 . . . cord-015021-pol2qm74 4123 1 Persistence persistence NN cord-015021-pol2qm74 4123 2 of of IN cord-015021-pol2qm74 4123 3 staphylococcal staphylococcal JJ cord-015021-pol2qm74 4123 4 infections infection NNS cord-015021-pol2qm74 4123 5 in in IN cord-015021-pol2qm74 4123 6 the the DT cord-015021-pol2qm74 4123 7 burn burn NN cord-015021-pol2qm74 4123 8 patient patient NN cord-015021-pol2qm74 4123 9 may may MD cord-015021-pol2qm74 4123 10 support support VB cord-015021-pol2qm74 4123 11 this this DT cord-015021-pol2qm74 4123 12 assumption assumption NN cord-015021-pol2qm74 4123 13 . . . cord-015021-pol2qm74 4124 1 RESPONSE response NN cord-015021-pol2qm74 4124 2 FOLLOWING FOLLOWING NNP cord-015021-pol2qm74 4124 3 TRAUMA trauma NN cord-015021-pol2qm74 4124 4 JANE JANE NNP cord-015021-pol2qm74 4124 5 SHELBY SHELBY NNP cord-015021-pol2qm74 4124 6 , , , cord-015021-pol2qm74 4125 1 Ph.D. Ph.D. NNP cord-015021-pol2qm74 4125 2 The the DT cord-015021-pol2qm74 4125 3 immune immune JJ cord-015021-pol2qm74 4125 4 system system NN cord-015021-pol2qm74 4125 5 is be VBZ cord-015021-pol2qm74 4125 6 integrated integrate VBN cord-015021-pol2qm74 4125 7 with with IN cord-015021-pol2qm74 4125 8 other other JJ cord-015021-pol2qm74 4125 9 physiologic physiologic JJ cord-015021-pol2qm74 4125 10 systems system NNS cord-015021-pol2qm74 4125 11 , , , cord-015021-pol2qm74 4125 12 and and CC cord-015021-pol2qm74 4125 13 is be VBZ cord-015021-pol2qm74 4125 14 exquisitely exquisitely RB cord-015021-pol2qm74 4125 15 sensitive sensitive JJ cord-015021-pol2qm74 4125 16 to to IN cord-015021-pol2qm74 4125 17 changes change NNS cord-015021-pol2qm74 4125 18 in in IN cord-015021-pol2qm74 4125 19 nervous nervous JJ cord-015021-pol2qm74 4125 20 and and CC cord-015021-pol2qm74 4125 21 endocrine endocrine JJ cord-015021-pol2qm74 4125 22 systems system NNS cord-015021-pol2qm74 4125 23 changes change VBZ cord-015021-pol2qm74 4125 24 following follow VBG cord-015021-pol2qm74 4125 25 traumatic traumatic JJ cord-015021-pol2qm74 4125 26 stress stress NN cord-015021-pol2qm74 4125 27 challenge challenge NN cord-015021-pol2qm74 4125 28 . . . cord-015021-pol2qm74 4126 1 The the DT cord-015021-pol2qm74 4126 2 immune immune JJ cord-015021-pol2qm74 4126 3 , , , cord-015021-pol2qm74 4126 4 nervous nervous JJ cord-015021-pol2qm74 4126 5 and and CC cord-015021-pol2qm74 4126 6 endocrine endocrine JJ cord-015021-pol2qm74 4126 7 systems system NNS cord-015021-pol2qm74 4126 8 interact interact VBP cord-015021-pol2qm74 4126 9 via via IN cord-015021-pol2qm74 4126 10 both both CC cord-015021-pol2qm74 4126 11 direct direct JJ cord-015021-pol2qm74 4126 12 and and CC cord-015021-pol2qm74 4126 13 indirect indirect JJ cord-015021-pol2qm74 4126 14 pathways pathway NNS cord-015021-pol2qm74 4126 15 which which WDT cord-015021-pol2qm74 4126 16 utilize utilize VBP cord-015021-pol2qm74 4126 17 neuro neuro NNP cord-015021-pol2qm74 4126 18 and and CC cord-015021-pol2qm74 4126 19 endocrine endocrine JJ cord-015021-pol2qm74 4126 20 hormones hormone NNS cord-015021-pol2qm74 4126 21 , , , cord-015021-pol2qm74 4126 22 neurotransmitters neurotransmitter NNS cord-015021-pol2qm74 4126 23 , , , cord-015021-pol2qm74 4126 24 neurepeptides neurepeptide NNS cord-015021-pol2qm74 4126 25 and and CC cord-015021-pol2qm74 4126 26 immune immune JJ cord-015021-pol2qm74 4126 27 cell cell NN cord-015021-pol2qm74 4126 28 products product NNS cord-015021-pol2qm74 4126 29 . . . cord-015021-pol2qm74 4127 1 It -PRON- PRP cord-015021-pol2qm74 4127 2 is be VBZ cord-015021-pol2qm74 4127 3 now now RB cord-015021-pol2qm74 4127 4 known know VBN cord-015021-pol2qm74 4127 5 that that IN cord-015021-pol2qm74 4127 6 the the DT cord-015021-pol2qm74 4127 7 immune immune JJ cord-015021-pol2qm74 4127 8 system system NN cord-015021-pol2qm74 4127 9 may may MD cord-015021-pol2qm74 4127 10 be be VB cord-015021-pol2qm74 4127 11 affected affect VBN cord-015021-pol2qm74 4127 12 by by IN cord-015021-pol2qm74 4127 13 all all DT cord-015021-pol2qm74 4127 14 of of IN cord-015021-pol2qm74 4127 15 the the DT cord-015021-pol2qm74 4127 16 neuroendocrine neuroendocrine JJ cord-015021-pol2qm74 4127 17 products product NNS cord-015021-pol2qm74 4127 18 produced produce VBN cord-015021-pol2qm74 4127 19 during during IN cord-015021-pol2qm74 4127 20 a a DT cord-015021-pol2qm74 4127 21 stress stress NN cord-015021-pol2qm74 4127 22 response response NN cord-015021-pol2qm74 4127 23 , , , cord-015021-pol2qm74 4127 24 with with IN cord-015021-pol2qm74 4127 25 evidence evidence NN cord-015021-pol2qm74 4127 26 for for IN cord-015021-pol2qm74 4127 27 innervation innervation NN cord-015021-pol2qm74 4127 28 of of IN cord-015021-pol2qm74 4127 29 iymphoid iymphoid NNP cord-015021-pol2qm74 4127 30 organs organ NNS cord-015021-pol2qm74 4127 31 , , , cord-015021-pol2qm74 4127 32 lymphoid lymphoid JJ cord-015021-pol2qm74 4127 33 cell cell NN cord-015021-pol2qm74 4127 34 receptors receptor NNS cord-015021-pol2qm74 4127 35 for for IN cord-015021-pol2qm74 4127 36 neuroendocdne neuroendocdne NNP cord-015021-pol2qm74 4127 37 products product NNS cord-015021-pol2qm74 4127 38 , , , cord-015021-pol2qm74 4127 39 and and CC cord-015021-pol2qm74 4127 40 leukocyte leukocyte NN cord-015021-pol2qm74 4127 41 production production NN cord-015021-pol2qm74 4127 42 of of IN cord-015021-pol2qm74 4127 43 chemicals chemical NNS cord-015021-pol2qm74 4127 44 which which WDT cord-015021-pol2qm74 4127 45 are be VBP cord-015021-pol2qm74 4127 46 virtually virtually RB cord-015021-pol2qm74 4127 47 identical identical JJ cord-015021-pol2qm74 4127 48 to to IN cord-015021-pol2qm74 4127 49 certain certain JJ cord-015021-pol2qm74 4127 50 neuroendocdne neuroendocdne NNP cord-015021-pol2qm74 4127 51 peptides peptide NNS cord-015021-pol2qm74 4127 52 ( ( -LRB- cord-015021-pol2qm74 4127 53 ACTH ACTH NNP cord-015021-pol2qm74 4127 54 , , , cord-015021-pol2qm74 4127 55 endorphins endorphin NNS cord-015021-pol2qm74 4127 56 ) ) -RRB- cord-015021-pol2qm74 4127 57 . . . cord-015021-pol2qm74 4128 1 Trauma trauma NN cord-015021-pol2qm74 4128 2 induced induce VBN cord-015021-pol2qm74 4128 3 alterations alteration NNS cord-015021-pol2qm74 4128 4 in in IN cord-015021-pol2qm74 4128 5 the the DT cord-015021-pol2qm74 4128 6 equilibrium equilibrium NN cord-015021-pol2qm74 4128 7 of of IN cord-015021-pol2qm74 4128 8 various various JJ cord-015021-pol2qm74 4128 9 neuropeptides neuropeptide NNS cord-015021-pol2qm74 4128 10 and and CC cord-015021-pol2qm74 4128 11 neuroendocdne neuroendocdne NNP cord-015021-pol2qm74 4128 12 hormones hormone NNS cord-015021-pol2qm74 4128 13 have have VBP cord-015021-pol2qm74 4128 14 a a DT cord-015021-pol2qm74 4128 15 significant significant JJ cord-015021-pol2qm74 4128 16 impact impact NN cord-015021-pol2qm74 4128 17 on on IN cord-015021-pol2qm74 4128 18 immune immune JJ cord-015021-pol2qm74 4128 19 response response NN cord-015021-pol2qm74 4128 20 potential potential NN cord-015021-pol2qm74 4128 21 , , , cord-015021-pol2qm74 4128 22 affecting affect VBG cord-015021-pol2qm74 4128 23 control control NN cord-015021-pol2qm74 4128 24 of of IN cord-015021-pol2qm74 4128 25 proliferation proliferation NN cord-015021-pol2qm74 4128 26 , , , cord-015021-pol2qm74 4128 27 differentiation differentiation NN cord-015021-pol2qm74 4128 28 and and CC cord-015021-pol2qm74 4128 29 function function NN cord-015021-pol2qm74 4128 30 of of IN cord-015021-pol2qm74 4128 31 immune immune JJ cord-015021-pol2qm74 4128 32 cells cell NNS cord-015021-pol2qm74 4128 33 . . . cord-015021-pol2qm74 4129 1 For for IN cord-015021-pol2qm74 4129 2 example example NN cord-015021-pol2qm74 4129 3 , , , cord-015021-pol2qm74 4129 4 the the DT cord-015021-pol2qm74 4129 5 neurohormone neurohormone NNP cord-015021-pol2qm74 4129 6 melatonin melatonin NNP cord-015021-pol2qm74 4129 7 is be VBZ cord-015021-pol2qm74 4129 8 thought think VBN cord-015021-pol2qm74 4129 9 to to TO cord-015021-pol2qm74 4129 10 be be VB cord-015021-pol2qm74 4129 11 a a DT cord-015021-pol2qm74 4129 12 natural natural JJ cord-015021-pol2qm74 4129 13 antagonist antagonist NN cord-015021-pol2qm74 4129 14 to to TO cord-015021-pol2qm74 4129 15 counteract counteract VB cord-015021-pol2qm74 4129 16 glucocorticeid glucocorticeid NN cord-015021-pol2qm74 4129 17 associated associate VBN cord-015021-pol2qm74 4129 18 immunosuppression immunosuppression NN cord-015021-pol2qm74 4129 19 resulting result VBG cord-015021-pol2qm74 4129 20 from from IN cord-015021-pol2qm74 4129 21 stressful stressful JJ cord-015021-pol2qm74 4129 22 challenges challenge NNS cord-015021-pol2qm74 4129 23 , , , cord-015021-pol2qm74 4129 24 such such JJ cord-015021-pol2qm74 4129 25 as as IN cord-015021-pol2qm74 4129 26 surgery surgery NN cord-015021-pol2qm74 4129 27 and and CC cord-015021-pol2qm74 4129 28 trauma trauma NN cord-015021-pol2qm74 4129 29 , , , cord-015021-pol2qm74 4129 30 Plasma plasma NN cord-015021-pol2qm74 4129 31 melatonin melatonin NN cord-015021-pol2qm74 4129 32 levels level NNS cord-015021-pol2qm74 4129 33 are be VBP cord-015021-pol2qm74 4129 34 known know VBN cord-015021-pol2qm74 4129 35 to to TO cord-015021-pol2qm74 4129 36 be be VB cord-015021-pol2qm74 4129 37 significantly significantly RB cord-015021-pol2qm74 4129 38 reduced reduce VBN cord-015021-pol2qm74 4129 39 in in IN cord-015021-pol2qm74 4129 40 burn burn NN cord-015021-pol2qm74 4129 41 patients patient NNS cord-015021-pol2qm74 4129 42 . . . cord-015021-pol2qm74 4130 1 The the DT cord-015021-pol2qm74 4130 2 administration administration NN cord-015021-pol2qm74 4130 3 of of IN cord-015021-pol2qm74 4130 4 exogenous exogenous JJ cord-015021-pol2qm74 4130 5 me[atonin me[atonin NNP cord-015021-pol2qm74 4130 6 improved improve VBD cord-015021-pol2qm74 4130 7 cellular cellular JJ cord-015021-pol2qm74 4130 8 immune immune JJ cord-015021-pol2qm74 4130 9 response response NN cord-015021-pol2qm74 4130 10 following follow VBG cord-015021-pol2qm74 4130 11 burn burn NN cord-015021-pol2qm74 4130 12 injury injury NN cord-015021-pol2qm74 4130 13 in in IN cord-015021-pol2qm74 4130 14 an an DT cord-015021-pol2qm74 4130 15 animal animal NN cord-015021-pol2qm74 4130 16 model model NN cord-015021-pol2qm74 4130 17 . . . cord-015021-pol2qm74 4131 1 Melatonin melatonin NN cord-015021-pol2qm74 4131 2 was be VBD cord-015021-pol2qm74 4131 3 also also RB cord-015021-pol2qm74 4131 4 shown show VBN cord-015021-pol2qm74 4131 5 to to TO cord-015021-pol2qm74 4131 6 have have VB cord-015021-pol2qm74 4131 7 in in IN cord-015021-pol2qm74 4131 8 vivo vivo NN cord-015021-pol2qm74 4131 9 cytokine cytokine JJ cord-015021-pol2qm74 4131 10 regulatory regulatory JJ cord-015021-pol2qm74 4131 11 activity activity NN cord-015021-pol2qm74 4131 12 , , , cord-015021-pol2qm74 4131 13 increasing increase VBG cord-015021-pol2qm74 4131 14 the the DT cord-015021-pol2qm74 4131 15 potential potential NN cord-015021-pol2qm74 4131 16 for for IN cord-015021-pol2qm74 4131 17 IL-2 il-2 NN cord-015021-pol2qm74 4131 18 secretion secretion NN cord-015021-pol2qm74 4131 19 and and CC cord-015021-pol2qm74 4131 20 downregulating downregulate VBG cord-015021-pol2qm74 4131 21 excessive excessive JJ cord-015021-pol2qm74 4131 22 IL-6 IL-6 NNP cord-015021-pol2qm74 4131 23 and and CC cord-015021-pol2qm74 4131 24 IFN~ IFN~ NNS cord-015021-pol2qm74 4131 25 in in IN cord-015021-pol2qm74 4131 26 burn burn NN cord-015021-pol2qm74 4131 27 injured injure VBN cord-015021-pol2qm74 4131 28 , , , cord-015021-pol2qm74 4131 29 stress stress NN cord-015021-pol2qm74 4131 30 susceptible susceptible JJ cord-015021-pol2qm74 4131 31 mice mouse NNS cord-015021-pol2qm74 4131 32 . . . cord-015021-pol2qm74 4132 1 The the DT cord-015021-pol2qm74 4132 2 regulatory regulatory JJ cord-015021-pol2qm74 4132 3 interactions interaction NNS cord-015021-pol2qm74 4132 4 between between IN cord-015021-pol2qm74 4132 5 the the DT cord-015021-pol2qm74 4132 6 immune immune JJ cord-015021-pol2qm74 4132 7 , , , cord-015021-pol2qm74 4132 8 nervous nervous JJ cord-015021-pol2qm74 4132 9 and and CC cord-015021-pol2qm74 4132 10 endocrine endocrine JJ cord-015021-pol2qm74 4132 11 systems system NNS cord-015021-pol2qm74 4132 12 provide provide VBP cord-015021-pol2qm74 4132 13 mechanistic mechanistic JJ cord-015021-pol2qm74 4132 14 pathways pathway NNS cord-015021-pol2qm74 4132 15 for for IN cord-015021-pol2qm74 4132 16 trauma trauma NN cord-015021-pol2qm74 4132 17 associated associate VBD cord-015021-pol2qm74 4132 18 immune immune JJ cord-015021-pol2qm74 4132 19 dysfunction dysfunction NN cord-015021-pol2qm74 4132 20 . . . cord-015021-pol2qm74 4133 1 Increased increase VBN cord-015021-pol2qm74 4133 2 knowledge knowledge NN cord-015021-pol2qm74 4133 3 of of IN cord-015021-pol2qm74 4133 4 these these DT cord-015021-pol2qm74 4133 5 interactions interaction NNS cord-015021-pol2qm74 4133 6 will will MD cord-015021-pol2qm74 4133 7 enhance enhance VB cord-015021-pol2qm74 4133 8 the the DT cord-015021-pol2qm74 4133 9 potential potential NN cord-015021-pol2qm74 4133 10 for for IN cord-015021-pol2qm74 4133 11 the the DT cord-015021-pol2qm74 4133 12 design design NN cord-015021-pol2qm74 4133 13 of of IN cord-015021-pol2qm74 4133 14 novei novei JJ cord-015021-pol2qm74 4133 15 clinical clinical JJ cord-015021-pol2qm74 4133 16 interventions intervention NNS cord-015021-pol2qm74 4133 17 to to TO cord-015021-pol2qm74 4133 18 improve improve VB cord-015021-pol2qm74 4133 19 immune immune JJ cord-015021-pol2qm74 4133 20 response response NN cord-015021-pol2qm74 4133 21 and and CC cord-015021-pol2qm74 4133 22 decrease decrease VB cord-015021-pol2qm74 4133 23 the the DT cord-015021-pol2qm74 4133 24 risk risk NN cord-015021-pol2qm74 4133 25 for for IN cord-015021-pol2qm74 4133 26 infection infection NN cord-015021-pol2qm74 4133 27 in in IN cord-015021-pol2qm74 4133 28 trauma trauma NN cord-015021-pol2qm74 4133 29 and and CC cord-015021-pol2qm74 4133 30 surgical surgical JJ cord-015021-pol2qm74 4133 31 patients patient NNS cord-015021-pol2qm74 4133 32 . . . cord-015021-pol2qm74 4134 1 . . . cord-015021-pol2qm74 4135 1 Animals animal NNS cord-015021-pol2qm74 4135 2 receiving receive VBG cord-015021-pol2qm74 4135 3 E E NNS cord-015021-pol2qm74 4135 4 were be VBD cord-015021-pol2qm74 4135 5 given give VBN cord-015021-pol2qm74 4135 6 a a DT cord-015021-pol2qm74 4135 7 single single JJ cord-015021-pol2qm74 4135 8 dose dose NN cord-015021-pol2qm74 4135 9 daily daily RB cord-015021-pol2qm74 4135 10 of of IN cord-015021-pol2qm74 4135 11 either either DT cord-015021-pol2qm74 4135 12 2.4 2.4 CD cord-015021-pol2qm74 4135 13 g g NN cord-015021-pol2qm74 4135 14 / / SYM cord-015021-pol2qm74 4135 15 kg kg NN cord-015021-pol2qm74 4135 16 of of IN cord-015021-pol2qm74 4135 17 E e NN cord-015021-pol2qm74 4135 18 in in IN cord-015021-pol2qm74 4135 19 a a DT cord-015021-pol2qm74 4135 20 20 20 CD cord-015021-pol2qm74 4135 21 % % NN cord-015021-pol2qm74 4135 22 solution solution NN cord-015021-pol2qm74 4135 23 by by IN cord-015021-pol2qm74 4135 24 garage garage NN cord-015021-pol2qm74 4135 25 ( ( -LRB- cord-015021-pol2qm74 4135 26 GE GE NNP cord-015021-pol2qm74 4135 27 ) ) -RRB- cord-015021-pol2qm74 4135 28 , , , cord-015021-pol2qm74 4135 29 or or CC cord-015021-pol2qm74 4135 30 1.25 1.25 CD cord-015021-pol2qm74 4135 31 g g NN cord-015021-pol2qm74 4135 32 / / SYM cord-015021-pol2qm74 4135 33 kg kg NNS cord-015021-pol2qm74 4135 34 of of IN cord-015021-pol2qm74 4135 35 sterile sterile JJ cord-015021-pol2qm74 4135 36 IVE IVE NNP cord-015021-pol2qm74 4135 37 in in IN cord-015021-pol2qm74 4135 38 saline saline NN cord-015021-pol2qm74 4135 39 . . . cord-015021-pol2qm74 4136 1 Four four CD cord-015021-pol2qm74 4136 2 hours hour NNS cord-015021-pol2qm74 4136 3 following follow VBG cord-015021-pol2qm74 4136 4 the the DT cord-015021-pol2qm74 4136 5 last last JJ cord-015021-pol2qm74 4136 6 dose dose NN cord-015021-pol2qm74 4136 7 , , , cord-015021-pol2qm74 4136 8 bum bum JJ cord-015021-pol2qm74 4136 9 animals animal NNS cord-015021-pol2qm74 4136 10 were be VBD cord-015021-pol2qm74 4136 11 subjected subject VBN cord-015021-pol2qm74 4136 12 to to IN cord-015021-pol2qm74 4136 13 a a DT cord-015021-pol2qm74 4136 14 30 30 CD cord-015021-pol2qm74 4136 15 % % NN cord-015021-pol2qm74 4136 16 body body NN cord-015021-pol2qm74 4136 17 surface surface NN cord-015021-pol2qm74 4136 18 area area NN cord-015021-pol2qm74 4136 19 bum bum JJ cord-015021-pol2qm74 4136 20 injury injury NN cord-015021-pol2qm74 4136 21 to to IN cord-015021-pol2qm74 4136 22 their -PRON- PRP$ cord-015021-pol2qm74 4136 23 dorsum dorsum NN cord-015021-pol2qm74 4136 24 . . . cord-015021-pol2qm74 4137 1 Twentyfour twentyfour NN cord-015021-pol2qm74 4137 2 hours hour NNS cord-015021-pol2qm74 4137 3 following follow VBG cord-015021-pol2qm74 4137 4 injury injury NN cord-015021-pol2qm74 4137 5 , , , cord-015021-pol2qm74 4137 6 the the DT cord-015021-pol2qm74 4137 7 animals animal NNS cord-015021-pol2qm74 4137 8 were be VBD cord-015021-pol2qm74 4137 9 sacrificed sacrifice VBN cord-015021-pol2qm74 4137 10 and and CC cord-015021-pol2qm74 4137 11 spleen spleen NN cord-015021-pol2qm74 4137 12 cells cell NNS cord-015021-pol2qm74 4137 13 were be VBD cord-015021-pol2qm74 4137 14 harvested harvest VBN cord-015021-pol2qm74 4137 15 for for IN cord-015021-pol2qm74 4137 16 assessment assessment NN cord-015021-pol2qm74 4137 17 of of IN cord-015021-pol2qm74 4137 18 lymphocyte lymphocyte NN cord-015021-pol2qm74 4137 19 function function NN cord-015021-pol2qm74 4137 20 . . . cord-015021-pol2qm74 4138 1 Splenocytes Splenocytes NNP cord-015021-pol2qm74 4138 2 were be VBD cord-015021-pol2qm74 4138 3 prepared prepare VBN cord-015021-pol2qm74 4138 4 by by IN cord-015021-pol2qm74 4138 5 mincing mince VBG cord-015021-pol2qm74 4138 6 the the DT cord-015021-pol2qm74 4138 7 spleen spleen NNS cord-015021-pol2qm74 4138 8 , , , cord-015021-pol2qm74 4138 9 followed follow VBN cord-015021-pol2qm74 4138 10 by by IN cord-015021-pol2qm74 4138 11 incubation incubation NN cord-015021-pol2qm74 4138 12 on on IN cord-015021-pol2qm74 4138 13 glass glass NN cord-015021-pol2qm74 4138 14 petri petri JJ cord-015021-pol2qm74 4138 15 dishes dish NNS cord-015021-pol2qm74 4138 16 to to TO cord-015021-pol2qm74 4138 17 remove remove VB cord-015021-pol2qm74 4138 18 adherent adherent JJ cord-015021-pol2qm74 4138 19 macrophages macrophage NNS cord-015021-pol2qm74 4138 20 . . . cord-015021-pol2qm74 4139 1 Non non JJ cord-015021-pol2qm74 4139 2 - - JJ cord-015021-pol2qm74 4139 3 adherent adherent JJ cord-015021-pol2qm74 4139 4 cells cell NNS cord-015021-pol2qm74 4139 5 were be VBD cord-015021-pol2qm74 4139 6 then then RB cord-015021-pol2qm74 4139 7 tested test VBN cord-015021-pol2qm74 4139 8 for for IN cord-015021-pol2qm74 4139 9 proliferative proliferative JJ cord-015021-pol2qm74 4139 10 response response NN cord-015021-pol2qm74 4139 11 to to IN cord-015021-pol2qm74 4139 12 T t NN cord-015021-pol2qm74 4139 13 - - HYPH cord-015021-pol2qm74 4139 14 cell cell NN cord-015021-pol2qm74 4139 15 mitogen mitogen NN cord-015021-pol2qm74 4139 16 Concanavalin Concanavalin NNP cord-015021-pol2qm74 4139 17 A A NNP cord-015021-pol2qm74 4139 18 ( ( -LRB- cord-015021-pol2qm74 4139 19 Con Con NNP cord-015021-pol2qm74 4139 20 A A NNP cord-015021-pol2qm74 4139 21 ) ) -RRB- cord-015021-pol2qm74 4139 22 and and CC cord-015021-pol2qm74 4139 23 B b NN cord-015021-pol2qm74 4139 24 - - HYPH cord-015021-pol2qm74 4139 25 cell cell NN cord-015021-pol2qm74 4139 26 mitogen mitogen NN cord-015021-pol2qm74 4139 27 lipopolysaccharide lipopolysaccharide NN cord-015021-pol2qm74 4139 28 ( ( -LRB- cord-015021-pol2qm74 4139 29 LPS LPS NNP cord-015021-pol2qm74 4139 30 ) ) -RRB- cord-015021-pol2qm74 4139 31 . . . cord-015021-pol2qm74 4140 1 Data datum NNS cord-015021-pol2qm74 4140 2 were be VBD cord-015021-pol2qm74 4140 3 analyzed analyze VBN cord-015021-pol2qm74 4140 4 by by IN cord-015021-pol2qm74 4140 5 ANOVA ANOVA NNP cord-015021-pol2qm74 4140 6 . . . cord-015021-pol2qm74 4141 1 RESULTS result NNS cord-015021-pol2qm74 4141 2 : : : cord-015021-pol2qm74 4142 1 Chronic chronic JJ cord-015021-pol2qm74 4142 2 alcohol alcohol NN cord-015021-pol2qm74 4142 3 exposure exposure NN cord-015021-pol2qm74 4142 4 and and CC cord-015021-pol2qm74 4142 5 burn burn VB cord-015021-pol2qm74 4142 6 injury injury NN cord-015021-pol2qm74 4142 7 independently independently RB cord-015021-pol2qm74 4142 8 inhibit inhibit VBP cord-015021-pol2qm74 4142 9 lymphocyte lymphocyte NN cord-015021-pol2qm74 4142 10 response response NN cord-015021-pol2qm74 4142 11 to to IN cord-015021-pol2qm74 4142 12 Con Con NNP cord-015021-pol2qm74 4142 13 A A NNP cord-015021-pol2qm74 4142 14 but but CC cord-015021-pol2qm74 4142 15 not not RB cord-015021-pol2qm74 4142 16 to to IN cord-015021-pol2qm74 4142 17 LPS LPS NNP cord-015021-pol2qm74 4142 18 . . . cord-015021-pol2qm74 4143 1 The the DT cord-015021-pol2qm74 4143 2 combination combination NN cord-015021-pol2qm74 4143 3 of of IN cord-015021-pol2qm74 4143 4 E E NNP cord-015021-pol2qm74 4143 5 plus plus CC cord-015021-pol2qm74 4143 6 bum bum JJ cord-015021-pol2qm74 4143 7 injury injury NN cord-015021-pol2qm74 4143 8 , , , cord-015021-pol2qm74 4143 9 however however RB cord-015021-pol2qm74 4143 10 , , , cord-015021-pol2qm74 4143 11 pmfouedly pmfouedly RB cord-015021-pol2qm74 4143 12 decreases decrease VBZ cord-015021-pol2qm74 4143 13 this this DT cord-015021-pol2qm74 4143 14 response response NN cord-015021-pol2qm74 4143 15 to to IN cord-015021-pol2qm74 4143 16 both both DT cord-015021-pol2qm74 4143 17 Con Con NNP cord-015021-pol2qm74 4143 18 A A NNP cord-015021-pol2qm74 4143 19 and and CC cord-015021-pol2qm74 4143 20 LPS LPS NNP cord-015021-pol2qm74 4143 21 as as IN cord-015021-pol2qm74 4143 22 outlined outline VBN cord-015021-pol2qm74 4143 23 in in IN cord-015021-pol2qm74 4143 24 the the DT cord-015021-pol2qm74 4143 25 This this DT cord-015021-pol2qm74 4143 26 data data NN cord-015021-pol2qm74 4143 27 clearly clearly RB cord-015021-pol2qm74 4143 28 identifies identify VBZ cord-015021-pol2qm74 4143 29 the the DT cord-015021-pol2qm74 4143 30 synergistic synergistic JJ cord-015021-pol2qm74 4143 31 impairment impairment NN cord-015021-pol2qm74 4143 32 of of IN cord-015021-pol2qm74 4143 33 immune immune JJ cord-015021-pol2qm74 4143 34 function function NN cord-015021-pol2qm74 4143 35 produced produce VBN cord-015021-pol2qm74 4143 36 by by IN cord-015021-pol2qm74 4143 37 ethanol ethanol NN cord-015021-pol2qm74 4143 38 and and CC cord-015021-pol2qm74 4143 39 bum bum NN cord-015021-pol2qm74 4143 40 injury injury NN cord-015021-pol2qm74 4143 41 . . . cord-015021-pol2qm74 4144 1 It -PRON- PRP cord-015021-pol2qm74 4144 2 is be VBZ cord-015021-pol2qm74 4144 3 furthermore furthermore RB cord-015021-pol2qm74 4144 4 apparent apparent JJ cord-015021-pol2qm74 4144 5 that that IN cord-015021-pol2qm74 4144 6 Ibis Ibis NNP cord-015021-pol2qm74 4144 7 effect effect NN cord-015021-pol2qm74 4144 8 is be VBZ cord-015021-pol2qm74 4144 9 gut gut NN cord-015021-pol2qm74 4144 10 mediated mediate VBN cord-015021-pol2qm74 4144 11 and and CC cord-015021-pol2qm74 4144 12 that that IN cord-015021-pol2qm74 4144 13 gastrointestinal gastrointestinal JJ cord-015021-pol2qm74 4144 14 exposure exposure NN cord-015021-pol2qm74 4144 15 to to IN cord-015021-pol2qm74 4144 16 alcohol alcohol NN cord-015021-pol2qm74 4144 17 is be VBZ cord-015021-pol2qm74 4144 18 necessary necessary JJ cord-015021-pol2qm74 4144 19 to to TO cord-015021-pol2qm74 4144 20 produce produce VB cord-015021-pol2qm74 4144 21 this this DT cord-015021-pol2qm74 4144 22 effect effect NN cord-015021-pol2qm74 4144 23 . . . cord-015021-pol2qm74 4145 1 Further further JJ cord-015021-pol2qm74 4145 2 studies study NNS cord-015021-pol2qm74 4145 3 will will MD cord-015021-pol2qm74 4145 4 work work VB cord-015021-pol2qm74 4145 5 to to TO cord-015021-pol2qm74 4145 6 identify identify VB cord-015021-pol2qm74 4145 7 cellular cellular JJ cord-015021-pol2qm74 4145 8 and and CC cord-015021-pol2qm74 4145 9 subcellular subcellular JJ cord-015021-pol2qm74 4145 10 mechanisms mechanism NNS cord-015021-pol2qm74 4145 11 to to TO cord-015021-pol2qm74 4145 12 explain explain VB cord-015021-pol2qm74 4145 13 this this DT cord-015021-pol2qm74 4145 14 effect effect NN cord-015021-pol2qm74 4145 15 . . . cord-015021-pol2qm74 4146 1 In in IN cord-015021-pol2qm74 4146 2 experimental experimental JJ cord-015021-pol2qm74 4146 3 animal animal NN cord-015021-pol2qm74 4146 4 studies study NNS cord-015021-pol2qm74 4146 5 and and CC cord-015021-pol2qm74 4146 6 investigations investigation NNS cord-015021-pol2qm74 4146 7 on on IN cord-015021-pol2qm74 4146 8 human human JJ cord-015021-pol2qm74 4146 9 volunteers volunteer NNS cord-015021-pol2qm74 4146 10 endotoxin endotoxin NN cord-015021-pol2qm74 4146 11 infusion infusion NN cord-015021-pol2qm74 4146 12 is be VBZ cord-015021-pol2qm74 4146 13 mgulary mgulary NN cord-015021-pol2qm74 4146 14 accompanied accompany VBN cord-015021-pol2qm74 4146 15 by by IN cord-015021-pol2qm74 4146 16 the the DT cord-015021-pol2qm74 4146 17 release release NN cord-015021-pol2qm74 4146 18 of of IN cord-015021-pol2qm74 4146 19 the the DT cord-015021-pol2qm74 4146 20 cytokine cytokine NN cord-015021-pol2qm74 4146 21 tumor tumor NN cord-015021-pol2qm74 4146 22 necrosis necrosis NN cord-015021-pol2qm74 4146 23 factor factor NN cord-015021-pol2qm74 4146 24 a a NN cord-015021-pol2qm74 4146 25 ( ( -LRB- cord-015021-pol2qm74 4146 26 TNF-~ TNF-~ NNP cord-015021-pol2qm74 4146 27 ) ) -RRB- cord-015021-pol2qm74 4146 28 determined determine VBN cord-015021-pol2qm74 4146 29 by by IN cord-015021-pol2qm74 4146 30 ELISA ELISA NNP cord-015021-pol2qm74 4146 31 technique technique NN cord-015021-pol2qm74 4146 32 . . . cord-015021-pol2qm74 4147 1 In in IN cord-015021-pol2qm74 4147 2 patients patient NNS cord-015021-pol2qm74 4147 3 with with IN cord-015021-pol2qm74 4147 4 menigococcal menigococcal JJ cord-015021-pol2qm74 4147 5 sepsis sepsis NN cord-015021-pol2qm74 4147 6 also also RB cord-015021-pol2qm74 4147 7 elevated elevate VBD cord-015021-pol2qm74 4147 8 TNF TNF NNP cord-015021-pol2qm74 4147 9 - - : cord-015021-pol2qm74 4147 10 a a DT cord-015021-pol2qm74 4147 11 values value NNS cord-015021-pol2qm74 4147 12 have have VBP cord-015021-pol2qm74 4147 13 been be VBN cord-015021-pol2qm74 4147 14 found find VBN cord-015021-pol2qm74 4147 15 using use VBG cord-015021-pol2qm74 4147 16 a a DT cord-015021-pol2qm74 4147 17 functional functional JJ cord-015021-pol2qm74 4147 18 assay assay NN cord-015021-pol2qm74 4147 19 . . . cord-015021-pol2qm74 4148 1 We -PRON- PRP cord-015021-pol2qm74 4148 2 have have VBP cord-015021-pol2qm74 4148 3 studied study VBN cord-015021-pol2qm74 4148 4 the the DT cord-015021-pol2qm74 4148 5 role role NN cord-015021-pol2qm74 4148 6 of of IN cord-015021-pol2qm74 4148 7 TNF TNF NNP cord-015021-pol2qm74 4148 8 - - HYPH cord-015021-pol2qm74 4148 9 et et NNP cord-015021-pol2qm74 4148 10 in in IN cord-015021-pol2qm74 4148 11 surgical surgical JJ cord-015021-pol2qm74 4148 12 ICU ICU NNP cord-015021-pol2qm74 4148 13 patients patient NNS cord-015021-pol2qm74 4148 14 with with IN cord-015021-pol2qm74 4148 15 sepsis sepsis NN cord-015021-pol2qm74 4148 16 . . . cord-015021-pol2qm74 4149 1 Using use VBG cord-015021-pol2qm74 4149 2 functional functional JJ cord-015021-pol2qm74 4149 3 technique technique NN cord-015021-pol2qm74 4149 4 , , , cord-015021-pol2qm74 4149 5 we -PRON- PRP cord-015021-pol2qm74 4149 6 were be VBD cord-015021-pol2qm74 4149 7 not not RB cord-015021-pol2qm74 4149 8 able able JJ cord-015021-pol2qm74 4149 9 to to TO cord-015021-pol2qm74 4149 10 detect detect VB cord-015021-pol2qm74 4149 11 TNF-~ TNF-~ NNP cord-015021-pol2qm74 4149 12 activities activity NNS cord-015021-pol2qm74 4149 13 in in IN cord-015021-pol2qm74 4149 14 the the DT cord-015021-pol2qm74 4149 15 patient patient NN cord-015021-pol2qm74 4149 16 plasmas plasma NNS cord-015021-pol2qm74 4149 17 . . . cord-015021-pol2qm74 4150 1 When when WRB cord-015021-pol2qm74 4150 2 this this DT cord-015021-pol2qm74 4150 3 cytokine cytokine NN cord-015021-pol2qm74 4150 4 , , , cord-015021-pol2qm74 4150 5 however however RB cord-015021-pol2qm74 4150 6 , , , cord-015021-pol2qm74 4150 7 was be VBD cord-015021-pol2qm74 4150 8 determined determine VBN cord-015021-pol2qm74 4150 9 by by IN cord-015021-pol2qm74 4150 10 immunochemicaI immunochemicaI NNP cord-015021-pol2qm74 4150 11 technique technique NN cord-015021-pol2qm74 4150 12 ( ( -LRB- cord-015021-pol2qm74 4150 13 EL1SA EL1SA NNP cord-015021-pol2qm74 4150 14 ) ) -RRB- cord-015021-pol2qm74 4150 15 elevated elevate VBD cord-015021-pol2qm74 4150 16 TNF TNF NNP cord-015021-pol2qm74 4150 17 - - HYPH cord-015021-pol2qm74 4150 18 e~ e~ JJ cord-015021-pol2qm74 4150 19 values value NNS cord-015021-pol2qm74 4150 20 where where WRB cord-015021-pol2qm74 4150 21 frequently frequently RB cord-015021-pol2qm74 4150 22 oberserved oberserve VBN cord-015021-pol2qm74 4150 23 . . . cord-015021-pol2qm74 4151 1 In in IN cord-015021-pol2qm74 4151 2 order order NN cord-015021-pol2qm74 4151 3 to to TO cord-015021-pol2qm74 4151 4 further further RB cord-015021-pol2qm74 4151 5 elucidate elucidate VB cord-015021-pol2qm74 4151 6 these these DT cord-015021-pol2qm74 4151 7 observations observation NNS cord-015021-pol2qm74 4151 8 , , , cord-015021-pol2qm74 4151 9 we -PRON- PRP cord-015021-pol2qm74 4151 10 studied study VBD cord-015021-pol2qm74 4151 11 shedding shed VBG cord-015021-pol2qm74 4151 12 of of IN cord-015021-pol2qm74 4151 13 TNF TNF NNP cord-015021-pol2qm74 4151 14 receptors receptor NNS cord-015021-pol2qm74 4151 15 in in IN cord-015021-pol2qm74 4151 16 the the DT cord-015021-pol2qm74 4151 17 patients patient NNS cord-015021-pol2qm74 4151 18 . . . cord-015021-pol2qm74 4152 1 In in IN cord-015021-pol2qm74 4152 2 these these DT cord-015021-pol2qm74 4152 3 studies study NNS cord-015021-pol2qm74 4152 4 , , , cord-015021-pol2qm74 4152 5 we -PRON- PRP cord-015021-pol2qm74 4152 6 noticed notice VBD cord-015021-pol2qm74 4152 7 that that IN cord-015021-pol2qm74 4152 8 shedding shedding NN cord-015021-pol2qm74 4152 9 of of IN cord-015021-pol2qm74 4152 10 TNF TNF NNP cord-015021-pol2qm74 4152 11 receptors receptor NNS cord-015021-pol2qm74 4152 12 oecured oecure VBN cord-015021-pol2qm74 4152 13 regulary regulary RB cord-015021-pol2qm74 4152 14 in in IN cord-015021-pol2qm74 4152 15 the the DT cord-015021-pol2qm74 4152 16 patients patient NNS cord-015021-pol2qm74 4152 17 . . . cord-015021-pol2qm74 4153 1 At at IN cord-015021-pol2qm74 4153 2 the the DT cord-015021-pol2qm74 4153 3 time time NN cord-015021-pol2qm74 4153 4 of of IN cord-015021-pol2qm74 4153 5 diagnosis diagnosis NN cord-015021-pol2qm74 4153 6 , , , cord-015021-pol2qm74 4153 7 soluble soluble JJ cord-015021-pol2qm74 4153 8 TNF TNF NNP cord-015021-pol2qm74 4153 9 receptor receptor NN cord-015021-pol2qm74 4153 10 p55 p55 NN cord-015021-pol2qm74 4153 11 and and CC cord-015021-pol2qm74 4153 12 p75 p75 NNP cord-015021-pol2qm74 4153 13 were be VBD cord-015021-pol2qm74 4153 14 both both DT cord-015021-pol2qm74 4153 15 2 2 CD cord-015021-pol2qm74 4153 16 - - SYM cord-015021-pol2qm74 4153 17 3 3 CD cord-015021-pol2qm74 4153 18 fold fold VBP cord-015021-pol2qm74 4153 19 higher higher RBR cord-015021-pol2qm74 4153 20 than than IN cord-015021-pol2qm74 4153 21 values value NNS cord-015021-pol2qm74 4153 22 found find VBN cord-015021-pol2qm74 4153 23 in in IN cord-015021-pol2qm74 4153 24 plasma plasma NN cord-015021-pol2qm74 4153 25 samples sample NNS cord-015021-pol2qm74 4153 26 obtained obtain VBN cord-015021-pol2qm74 4153 27 prior prior RB cord-015021-pol2qm74 4153 28 to to TO cord-015021-pol2qm74 4153 29 die die VB cord-015021-pol2qm74 4153 30 diagnosis diagnosis NN cord-015021-pol2qm74 4153 31 of of IN cord-015021-pol2qm74 4153 32 sepsis sepsis NN cord-015021-pol2qm74 4153 33 . . . cord-015021-pol2qm74 4154 1 We -PRON- PRP cord-015021-pol2qm74 4154 2 also also RB cord-015021-pol2qm74 4154 3 observed observe VBD cord-015021-pol2qm74 4154 4 that that IN cord-015021-pol2qm74 4154 5 the the DT cord-015021-pol2qm74 4154 6 sepsis sepsis NN cord-015021-pol2qm74 4154 7 patients patient NNS cord-015021-pol2qm74 4154 8 revealed reveal VBD cord-015021-pol2qm74 4154 9 higher high JJR cord-015021-pol2qm74 4154 10 maximum maximum JJ cord-015021-pol2qm74 4154 11 values value NNS cord-015021-pol2qm74 4154 12 of of IN cord-015021-pol2qm74 4154 13 p55 p55 NN cord-015021-pol2qm74 4154 14 and and CC cord-015021-pol2qm74 4154 15 p75 p75 NN cord-015021-pol2qm74 4154 16 during during IN cord-015021-pol2qm74 4154 17 the the DT cord-015021-pol2qm74 4154 18 ICU ICU NNP cord-015021-pol2qm74 4154 19 stay stay NN cord-015021-pol2qm74 4154 20 compared compare VBN cord-015021-pol2qm74 4154 21 to to IN cord-015021-pol2qm74 4154 22 values value NNS cord-015021-pol2qm74 4154 23 found find VBN cord-015021-pol2qm74 4154 24 in in IN cord-015021-pol2qm74 4154 25 surgical surgical JJ cord-015021-pol2qm74 4154 26 ICU ICU NNP cord-015021-pol2qm74 4154 27 patients patient NNS cord-015021-pol2qm74 4154 28 without without IN cord-015021-pol2qm74 4154 29 sepsis sepsis NN cord-015021-pol2qm74 4154 30 . . . cord-015021-pol2qm74 4155 1 These these DT cord-015021-pol2qm74 4155 2 observations observation NNS cord-015021-pol2qm74 4155 3 indicate indicate VBP cord-015021-pol2qm74 4155 4 that that IN cord-015021-pol2qm74 4155 5 soluble soluble JJ cord-015021-pol2qm74 4155 6 TNF TNF NNP cord-015021-pol2qm74 4155 7 receptors receptor NNS cord-015021-pol2qm74 4155 8 are be VBP cord-015021-pol2qm74 4155 9 available available JJ cord-015021-pol2qm74 4155 10 in in IN cord-015021-pol2qm74 4155 11 sufficient sufficient JJ cord-015021-pol2qm74 4155 12 amounts amount NNS cord-015021-pol2qm74 4155 13 to to TO cord-015021-pol2qm74 4155 14 bind bind VB cord-015021-pol2qm74 4155 15 TNF TNF NNP cord-015021-pol2qm74 4155 16 - - HYPH cord-015021-pol2qm74 4155 17 ot ot NNP cord-015021-pol2qm74 4155 18 which which WDT cord-015021-pol2qm74 4155 19 is be VBZ cord-015021-pol2qm74 4155 20 released release VBN cord-015021-pol2qm74 4155 21 in in IN cord-015021-pol2qm74 4155 22 surgical surgical JJ cord-015021-pol2qm74 4155 23 patients patient NNS cord-015021-pol2qm74 4155 24 developing develop VBG cord-015021-pol2qm74 4155 25 sepsis sepsis NN cord-015021-pol2qm74 4155 26 . . . cord-015021-pol2qm74 4156 1 This this DT cord-015021-pol2qm74 4156 2 mechanism mechanism NN cord-015021-pol2qm74 4156 3 may may MD cord-015021-pol2qm74 4156 4 explain explain VB cord-015021-pol2qm74 4156 5 why why WRB cord-015021-pol2qm74 4156 6 functional functional JJ cord-015021-pol2qm74 4156 7 TNF TNF NNP cord-015021-pol2qm74 4156 8 - - HYPH cord-015021-pol2qm74 4156 9 c~ c~ NNP cord-015021-pol2qm74 4156 10 was be VBD cord-015021-pol2qm74 4156 11 not not RB cord-015021-pol2qm74 4156 12 detected detect VBN cord-015021-pol2qm74 4156 13 in in IN cord-015021-pol2qm74 4156 14 the the DT cord-015021-pol2qm74 4156 15 patients patient NNS cord-015021-pol2qm74 4156 16 . . . cord-015021-pol2qm74 4157 1 Institute Institute NNP cord-015021-pol2qm74 4157 2 for for IN cord-015021-pol2qm74 4157 3 Surgical Surgical NNP cord-015021-pol2qm74 4157 4 Research Research NNP cord-015021-pol2qm74 4157 5 , , , cord-015021-pol2qm74 4157 6 Rikshospitalet Rikshospitalet NNP cord-015021-pol2qm74 4157 7 , , , cord-015021-pol2qm74 4157 8 The the DT cord-015021-pol2qm74 4157 9 National National NNP cord-015021-pol2qm74 4157 10 Hospital Hospital NNP cord-015021-pol2qm74 4157 11 , , , cord-015021-pol2qm74 4157 12 University University NNP cord-015021-pol2qm74 4157 13 of of IN cord-015021-pol2qm74 4157 14 Oslo Oslo NNP cord-015021-pol2qm74 4157 15 , , , cord-015021-pol2qm74 4157 16 0027 0027 CD cord-015021-pol2qm74 4157 17 Oslo Oslo NNP cord-015021-pol2qm74 4157 18 , , , cord-015021-pol2qm74 4157 19 Norway Norway NNP cord-015021-pol2qm74 4157 20 . . . cord-015021-pol2qm74 4158 1 Decker Decker NNP cord-015021-pol2qm74 4158 2 , , , cord-015021-pol2qm74 4158 3 D. D. NNP cord-015021-pol2qm74 4158 4 , , , cord-015021-pol2qm74 4158 5 Sch6ndorf Sch6ndorf NNP cord-015021-pol2qm74 4158 6 , , , cord-015021-pol2qm74 4158 7 M. M. NNP cord-015021-pol2qm74 4158 8 , , , cord-015021-pol2qm74 4158 9 Bidlingrnaier Bidlingrnaier NNP cord-015021-pol2qm74 4158 10 , , , cord-015021-pol2qm74 4158 11 F. F. NNP cord-015021-pol2qm74 4158 12 , , , cord-015021-pol2qm74 4158 13 Hirner Hirner NNP cord-015021-pol2qm74 4158 14 , , , cord-015021-pol2qm74 4158 15 A. A. NNP cord-015021-pol2qm74 4158 16 , , , cord-015021-pol2qm74 4158 17 yon yon NNP cord-015021-pol2qm74 4158 18 Rfcker Rfcker NNP cord-015021-pol2qm74 4158 19 , , , cord-015021-pol2qm74 4158 20 A. a. NN cord-015021-pol2qm74 4159 1 The the DT cord-015021-pol2qm74 4159 2 advantage advantage NN cord-015021-pol2qm74 4159 3 oflaparoscopic oflaparoscopic JJ cord-015021-pol2qm74 4159 4 cholecystectomy cholecystectomy NN cord-015021-pol2qm74 4159 5 over over IN cord-015021-pol2qm74 4159 6 conventional conventional JJ cord-015021-pol2qm74 4159 7 open open JJ cord-015021-pol2qm74 4159 8 surgical surgical JJ cord-015021-pol2qm74 4159 9 approaches approach NNS cord-015021-pol2qm74 4159 10 in in IN cord-015021-pol2qm74 4159 11 the the DT cord-015021-pol2qm74 4159 12 treatment treatment NN cord-015021-pol2qm74 4159 13 of of IN cord-015021-pol2qm74 4159 14 symptomatic symptomatic JJ cord-015021-pol2qm74 4159 15 cholelithiasis cholelithiasis NN cord-015021-pol2qm74 4159 16 has have VBZ cord-015021-pol2qm74 4159 17 been be VBN cord-015021-pol2qm74 4159 18 shown show VBN cord-015021-pol2qm74 4159 19 convincingly convincingly RB cord-015021-pol2qm74 4159 20 by by IN cord-015021-pol2qm74 4159 21 clinical clinical JJ cord-015021-pol2qm74 4159 22 studies study NNS cord-015021-pol2qm74 4159 23 . . . cord-015021-pol2qm74 4160 1 In in IN cord-015021-pol2qm74 4160 2 order order NN cord-015021-pol2qm74 4160 3 to to TO cord-015021-pol2qm74 4160 4 facilitate facilitate VB cord-015021-pol2qm74 4160 5 comparisons comparison NNS cord-015021-pol2qm74 4160 6 of of IN cord-015021-pol2qm74 4160 7 different different JJ cord-015021-pol2qm74 4160 8 surgical surgical JJ cord-015021-pol2qm74 4160 9 approaches approach NNS cord-015021-pol2qm74 4160 10 , , , cord-015021-pol2qm74 4160 11 we -PRON- PRP cord-015021-pol2qm74 4160 12 evaluated evaluate VBD cord-015021-pol2qm74 4160 13 the the DT cord-015021-pol2qm74 4160 14 cell cell NN cord-015021-pol2qm74 4160 15 biological biological JJ cord-015021-pol2qm74 4160 16 characteristics characteristic NNS cord-015021-pol2qm74 4160 17 of of IN cord-015021-pol2qm74 4160 18 tissue tissue NN cord-015021-pol2qm74 4160 19 trauma trauma NN cord-015021-pol2qm74 4160 20 by by IN cord-015021-pol2qm74 4160 21 measuring measure VBG cord-015021-pol2qm74 4160 22 changes change NNS cord-015021-pol2qm74 4160 23 in in IN cord-015021-pol2qm74 4160 24 various various JJ cord-015021-pol2qm74 4160 25 cell cell NN cord-015021-pol2qm74 4160 26 surface surface NN cord-015021-pol2qm74 4160 27 markers marker NNS cord-015021-pol2qm74 4160 28 on on IN cord-015021-pol2qm74 4160 29 leukocytes leukocyte NNS cord-015021-pol2qm74 4160 30 and and CC cord-015021-pol2qm74 4160 31 eytokines eytokine NNS cord-015021-pol2qm74 4160 32 in in IN cord-015021-pol2qm74 4160 33 plasma plasma NN cord-015021-pol2qm74 4160 34 as as IN cord-015021-pol2qm74 4160 35 a a DT cord-015021-pol2qm74 4160 36 possible possible JJ cord-015021-pol2qm74 4160 37 means mean VBZ cord-015021-pol2qm74 4160 38 to to TO cord-015021-pol2qm74 4160 39 assess assess VB cord-015021-pol2qm74 4160 40 tissue tissue NN cord-015021-pol2qm74 4160 41 trauma trauma NN cord-015021-pol2qm74 4160 42 in in IN cord-015021-pol2qm74 4160 43 choleeystectomy choleeystectomy NN cord-015021-pol2qm74 4160 44 . . . cord-015021-pol2qm74 4161 1 Patients patient NNS cord-015021-pol2qm74 4161 2 recruited recruit VBN cord-015021-pol2qm74 4161 3 into into IN cord-015021-pol2qm74 4161 4 our -PRON- PRP$ cord-015021-pol2qm74 4161 5 study study NN cord-015021-pol2qm74 4161 6 had have VBD cord-015021-pol2qm74 4161 7 experienced experience VBN cord-015021-pol2qm74 4161 8 at at IN cord-015021-pol2qm74 4161 9 least least RBS cord-015021-pol2qm74 4161 10 one one CD cord-015021-pol2qm74 4161 11 typical typical JJ cord-015021-pol2qm74 4161 12 bifiary bifiary JJ cord-015021-pol2qm74 4161 13 colic colic NN cord-015021-pol2qm74 4161 14 , , , cord-015021-pol2qm74 4161 15 had have VBD cord-015021-pol2qm74 4161 16 ultrasound ultrasound NN cord-015021-pol2qm74 4161 17 - - HYPH cord-015021-pol2qm74 4161 18 proven prove VBN cord-015021-pol2qm74 4161 19 cholelithiasis cholelithiasis NN cord-015021-pol2qm74 4161 20 ( ( -LRB- cord-015021-pol2qm74 4161 21 stages stage NNS cord-015021-pol2qm74 4161 22 0-II 0-II NFP cord-015021-pol2qm74 4161 23 according accord VBG cord-015021-pol2qm74 4161 24 to to IN cord-015021-pol2qm74 4161 25 Me Me NNP cord-015021-pol2qm74 4161 26 Sherry Sherry NNP cord-015021-pol2qm74 4161 27 ) ) -RRB- cord-015021-pol2qm74 4161 28 , , , cord-015021-pol2qm74 4161 29 were be VBD cord-015021-pol2qm74 4161 30 35 35 CD cord-015021-pol2qm74 4161 31 - - SYM cord-015021-pol2qm74 4161 32 55 55 CD cord-015021-pol2qm74 4161 33 years year NNS cord-015021-pol2qm74 4161 34 old old JJ cord-015021-pol2qm74 4161 35 , , , cord-015021-pol2qm74 4161 36 and and CC cord-015021-pol2qm74 4161 37 presented present VBN cord-015021-pol2qm74 4161 38 for for IN cord-015021-pol2qm74 4161 39 elective elective JJ cord-015021-pol2qm74 4161 40 choleeysteetomy choleeysteetomy NN cord-015021-pol2qm74 4161 41 . . . cord-015021-pol2qm74 4162 1 Patients patient NNS cord-015021-pol2qm74 4162 2 could could MD cord-015021-pol2qm74 4162 3 choose choose VB cord-015021-pol2qm74 4162 4 between between IN cord-015021-pol2qm74 4162 5 laparoscopic laparoscopic JJ cord-015021-pol2qm74 4162 6 and and CC cord-015021-pol2qm74 4162 7 conventional conventional JJ cord-015021-pol2qm74 4162 8 eholeeystectomy eholeeystectomy NN cord-015021-pol2qm74 4162 9 after after IN cord-015021-pol2qm74 4162 10 being be VBG cord-015021-pol2qm74 4162 11 informed inform VBN cord-015021-pol2qm74 4162 12 about about IN cord-015021-pol2qm74 4162 13 the the DT cord-015021-pol2qm74 4162 14 advantages advantage NNS cord-015021-pol2qm74 4162 15 and and CC cord-015021-pol2qm74 4162 16 disadvantages disadvantage NNS cord-015021-pol2qm74 4162 17 of of IN cord-015021-pol2qm74 4162 18 each each DT cord-015021-pol2qm74 4162 19 procedure procedure NN cord-015021-pol2qm74 4162 20 . . . cord-015021-pol2qm74 4163 1 Cell cell NN cord-015021-pol2qm74 4163 2 surface surface NN cord-015021-pol2qm74 4163 3 markers marker NNS cord-015021-pol2qm74 4163 4 on on IN cord-015021-pol2qm74 4163 5 leukoeytes leukoeyte NNS cord-015021-pol2qm74 4163 6 were be VBD cord-015021-pol2qm74 4163 7 determined determine VBN cord-015021-pol2qm74 4163 8 using use VBG cord-015021-pol2qm74 4163 9 whole whole JJ cord-015021-pol2qm74 4163 10 blood blood NN cord-015021-pol2qm74 4163 11 techniques technique NNS cord-015021-pol2qm74 4163 12 with with IN cord-015021-pol2qm74 4163 13 the the DT cord-015021-pol2qm74 4163 14 help help NN cord-015021-pol2qm74 4163 15 of of IN cord-015021-pol2qm74 4163 16 commercially commercially RB cord-015021-pol2qm74 4163 17 available available JJ cord-015021-pol2qm74 4163 18 fluorescent fluorescent JJ cord-015021-pol2qm74 4163 19 monocloml monocloml NNS cord-015021-pol2qm74 4163 20 antibodies antibody NNS cord-015021-pol2qm74 4163 21 and and CC cord-015021-pol2qm74 4163 22 flow flow NN cord-015021-pol2qm74 4163 23 cytometry cytometry NN cord-015021-pol2qm74 4163 24 . . . cord-015021-pol2qm74 4164 1 Shed shed JJ cord-015021-pol2qm74 4164 2 cell cell NN cord-015021-pol2qm74 4164 3 surface surface NN cord-015021-pol2qm74 4164 4 markers marker NNS cord-015021-pol2qm74 4164 5 in in IN cord-015021-pol2qm74 4164 6 plasma plasma NN cord-015021-pol2qm74 4164 7 and and CC cord-015021-pol2qm74 4164 8 cytoldnes cytoldne NNS cord-015021-pol2qm74 4164 9 were be VBD cord-015021-pol2qm74 4164 10 measured measure VBN cord-015021-pol2qm74 4164 11 with with IN cord-015021-pol2qm74 4164 12 the the DT cord-015021-pol2qm74 4164 13 help help NN cord-015021-pol2qm74 4164 14 of of IN cord-015021-pol2qm74 4164 15 sandwich sandwich NN cord-015021-pol2qm74 4164 16 - - HYPH cord-015021-pol2qm74 4164 17 ELISA ELISA NNP cord-015021-pol2qm74 4164 18 kits kit NNS cord-015021-pol2qm74 4164 19 . . . cord-015021-pol2qm74 4165 1 Blood blood NN cord-015021-pol2qm74 4165 2 samples sample NNS cord-015021-pol2qm74 4165 3 were be VBD cord-015021-pol2qm74 4165 4 drawn draw VBN cord-015021-pol2qm74 4165 5 24 24 CD cord-015021-pol2qm74 4165 6 h h NN cord-015021-pol2qm74 4165 7 before before IN cord-015021-pol2qm74 4165 8 surgery surgery NN cord-015021-pol2qm74 4165 9 , , , cord-015021-pol2qm74 4165 10 immediately immediately RB cord-015021-pol2qm74 4165 11 before before IN cord-015021-pol2qm74 4165 12 incision incision NN cord-015021-pol2qm74 4165 13 ( ( -LRB- cord-015021-pol2qm74 4165 14 after after IN cord-015021-pol2qm74 4165 15 anaesthesia anaesthesia NN cord-015021-pol2qm74 4165 16 ) ) -RRB- cord-015021-pol2qm74 4165 17 , , , cord-015021-pol2qm74 4165 18 2 2 CD cord-015021-pol2qm74 4165 19 h h NN cord-015021-pol2qm74 4165 20 and and CC cord-015021-pol2qm74 4165 21 24 24 CD cord-015021-pol2qm74 4165 22 h h NN cord-015021-pol2qm74 4165 23 after after IN cord-015021-pol2qm74 4165 24 incision incision NN cord-015021-pol2qm74 4165 25 . . . cord-015021-pol2qm74 4166 1 Seventeen seventeen CD cord-015021-pol2qm74 4166 2 cell cell NN cord-015021-pol2qm74 4166 3 surface surface NN cord-015021-pol2qm74 4166 4 markers marker NNS cord-015021-pol2qm74 4166 5 were be VBD cord-015021-pol2qm74 4166 6 examined examine VBN cord-015021-pol2qm74 4166 7 on on IN cord-015021-pol2qm74 4166 8 different different JJ cord-015021-pol2qm74 4166 9 cell cell NN cord-015021-pol2qm74 4166 10 populations population NNS cord-015021-pol2qm74 4166 11 and and CC cord-015021-pol2qm74 4166 12 cellular cellular JJ cord-015021-pol2qm74 4166 13 subsets subset NNS cord-015021-pol2qm74 4166 14 in in IN cord-015021-pol2qm74 4166 15 18 18 CD cord-015021-pol2qm74 4166 16 laparoscopic laparoscopic NNS cord-015021-pol2qm74 4166 17 and and CC cord-015021-pol2qm74 4166 18 15 15 CD cord-015021-pol2qm74 4166 19 open open JJ cord-015021-pol2qm74 4166 20 - - HYPH cord-015021-pol2qm74 4166 21 surgery surgery NN cord-015021-pol2qm74 4166 22 patients patient NNS cord-015021-pol2qm74 4166 23 . . . cord-015021-pol2qm74 4167 1 Three three CD cord-015021-pol2qm74 4167 2 soluble soluble JJ cord-015021-pol2qm74 4167 3 cell cell NN cord-015021-pol2qm74 4167 4 surface surface NN cord-015021-pol2qm74 4167 5 markers marker NNS cord-015021-pol2qm74 4167 6 and and CC cord-015021-pol2qm74 4167 7 six six CD cord-015021-pol2qm74 4167 8 cytokines cytokine NNS cord-015021-pol2qm74 4167 9 were be VBD cord-015021-pol2qm74 4167 10 monitored monitor VBN cord-015021-pol2qm74 4167 11 . . . cord-015021-pol2qm74 4168 1 By by IN cord-015021-pol2qm74 4168 2 statistical statistical JJ cord-015021-pol2qm74 4168 3 analyses analysis NNS cord-015021-pol2qm74 4168 4 ( ( -LRB- cord-015021-pol2qm74 4168 5 multivariate multivariate JJ cord-015021-pol2qm74 4168 6 regression regression NN cord-015021-pol2qm74 4168 7 analysis analysis NN cord-015021-pol2qm74 4168 8 , , , cord-015021-pol2qm74 4168 9 Student Student NNP cord-015021-pol2qm74 4168 10 's 's POS cord-015021-pol2qm74 4168 11 t t NN cord-015021-pol2qm74 4168 12 test test NN cord-015021-pol2qm74 4168 13 , , , cord-015021-pol2qm74 4168 14 WilcoxomMann WilcoxomMann NNP cord-015021-pol2qm74 4168 15 - - HYPH cord-015021-pol2qm74 4168 16 Whituey Whituey NNP cord-015021-pol2qm74 4168 17 's 's POS cord-015021-pol2qm74 4168 18 rank rank NN cord-015021-pol2qm74 4168 19 sum sum NN cord-015021-pol2qm74 4168 20 test test NN cord-015021-pol2qm74 4168 21 ) ) -RRB- cord-015021-pol2qm74 4168 22 the the DT cord-015021-pol2qm74 4168 23 six six CD cord-015021-pol2qm74 4168 24 markers marker NNS cord-015021-pol2qm74 4168 25 / / SYM cord-015021-pol2qm74 4168 26 cytekines cytekine NNS cord-015021-pol2qm74 4168 27 that that WDT cord-015021-pol2qm74 4168 28 best well RBS cord-015021-pol2qm74 4168 29 distinguished distinguished JJ cord-015021-pol2qm74 4168 30 open open JJ cord-015021-pol2qm74 4168 31 surgical surgical NN cord-015021-pol2qm74 4168 32 from from IN cord-015021-pol2qm74 4168 33 laparoscopic laparoscopic JJ cord-015021-pol2qm74 4168 34 procedurea procedurea NNP cord-015021-pol2qm74 4168 35 were be VBD cord-015021-pol2qm74 4168 36 determined determine VBN cord-015021-pol2qm74 4168 37 . . . cord-015021-pol2qm74 4169 1 These these DT cord-015021-pol2qm74 4169 2 were be VBD cord-015021-pol2qm74 4169 3 1 1 CD cord-015021-pol2qm74 4169 4 . . . cord-015021-pol2qm74 4170 1 the the DT cord-015021-pol2qm74 4170 2 interleuldn-2 interleuldn-2 NNP cord-015021-pol2qm74 4170 3 receptor receptor NN cord-015021-pol2qm74 4170 4 and and CC cord-015021-pol2qm74 4170 5 i -PRON- PRP cord-015021-pol2qm74 4170 6 m be VBP cord-015021-pol2qm74 4170 7 soluble soluble JJ cord-015021-pol2qm74 4170 8 form form NN cord-015021-pol2qm74 4170 9 ( ( -LRB- cord-015021-pol2qm74 4170 10 CD25 CD25 NNP cord-015021-pol2qm74 4170 11 / / SYM cord-015021-pol2qm74 4170 12 sCD25 sCD25 NNP cord-015021-pol2qm74 4170 13 ) ) -RRB- cord-015021-pol2qm74 4170 14 ; ; : cord-015021-pol2qm74 4170 15 2 2 CD cord-015021-pol2qm74 4170 16 . . . cord-015021-pol2qm74 4171 1 the the DT cord-015021-pol2qm74 4171 2 activation activation NN cord-015021-pol2qm74 4171 3 antigen antigen NN cord-015021-pol2qm74 4171 4 Fd-1 Fd-1 NNP cord-015021-pol2qm74 4171 5 and and CC cord-015021-pol2qm74 4171 6 its -PRON- PRP$ cord-015021-pol2qm74 4171 7 soluble soluble JJ cord-015021-pol2qm74 4171 8 form form NN cord-015021-pol2qm74 4171 9 ( ( -LRB- cord-015021-pol2qm74 4171 10 CD30 CD30 NNP cord-015021-pol2qm74 4171 11 / / SYM cord-015021-pol2qm74 4171 12 sCD30 sCD30 NNP cord-015021-pol2qm74 4171 13 ) ) -RRB- cord-015021-pol2qm74 4171 14 , , , cord-015021-pol2qm74 4171 15 a a DT cord-015021-pol2qm74 4171 16 member member NN cord-015021-pol2qm74 4171 17 of of IN cord-015021-pol2qm74 4171 18 the the DT cord-015021-pol2qm74 4171 19 nerve nerve NN cord-015021-pol2qm74 4171 20 - - HYPH cord-015021-pol2qm74 4171 21 growth growth NN cord-015021-pol2qm74 4171 22 - - HYPH cord-015021-pol2qm74 4171 23 factor factor NN cord-015021-pol2qm74 4171 24 receptor receptor NN cord-015021-pol2qm74 4171 25 family family NN cord-015021-pol2qm74 4171 26 ; ; : cord-015021-pol2qm74 4171 27 3 3 CD cord-015021-pol2qm74 4171 28 . . . cord-015021-pol2qm74 4172 1 the the DT cord-015021-pol2qm74 4172 2 CD45RO CD45RO NNP cord-015021-pol2qm74 4172 3 epitope epitope NN cord-015021-pol2qm74 4172 4 which which WDT cord-015021-pol2qm74 4172 5 characterizes characterize VBZ cord-015021-pol2qm74 4172 6 T T NNP cord-015021-pol2qm74 4172 7 memory memory NN cord-015021-pol2qm74 4172 8 ceils ceil NNS cord-015021-pol2qm74 4172 9 ; ; : cord-015021-pol2qm74 4172 10 4 4 CD cord-015021-pol2qm74 4172 11 . . . cord-015021-pol2qm74 4173 1 the the DT cord-015021-pol2qm74 4173 2 trausferrin trausferrin NNP cord-015021-pol2qm74 4173 3 receptor receptor NN cord-015021-pol2qm74 4173 4 CD71 CD71 NNP cord-015021-pol2qm74 4173 5 ; ; : cord-015021-pol2qm74 4173 6 5 5 CD cord-015021-pol2qm74 4173 7 . . . cord-015021-pol2qm74 4174 1 the the DT cord-015021-pol2qm74 4174 2 soluble soluble JJ cord-015021-pol2qm74 4174 3 adhesion adhesion NN cord-015021-pol2qm74 4174 4 molecule molecule NN cord-015021-pol2qm74 4174 5 ICAM-1 icam-1 NN cord-015021-pol2qm74 4174 6 ; ; : cord-015021-pol2qm74 4174 7 and and CC cord-015021-pol2qm74 4174 8 6 6 CD cord-015021-pol2qm74 4174 9 . . . cord-015021-pol2qm74 4175 1 the the DT cord-015021-pol2qm74 4175 2 cytokines cytokine NNS cord-015021-pol2qm74 4175 3 interieukin-6 interieukin-6 NNPS cord-015021-pol2qm74 4175 4 and and CC cord-015021-pol2qm74 4175 5 interleuldn-8 interleuldn-8 NNP cord-015021-pol2qm74 4175 6 . . . cord-015021-pol2qm74 4176 1 On on IN cord-015021-pol2qm74 4176 2 the the DT cord-015021-pol2qm74 4176 3 basis basis NN cord-015021-pol2qm74 4176 4 of of IN cord-015021-pol2qm74 4176 5 these these DT cord-015021-pol2qm74 4176 6 results result NNS cord-015021-pol2qm74 4176 7 , , , cord-015021-pol2qm74 4176 8 a a DT cord-015021-pol2qm74 4176 9 tissue tissue NN cord-015021-pol2qm74 4176 10 trauma trauma NN cord-015021-pol2qm74 4176 11 activation activation NN cord-015021-pol2qm74 4176 12 ( ( -LRB- cord-015021-pol2qm74 4176 13 TTA TTA NNP cord-015021-pol2qm74 4176 14 ) ) -RRB- cord-015021-pol2qm74 4176 15 index index NN cord-015021-pol2qm74 4176 16 was be VBD cord-015021-pol2qm74 4176 17 calculated calculate VBN cord-015021-pol2qm74 4176 18 by by IN cord-015021-pol2qm74 4176 19 combining combine VBG cord-015021-pol2qm74 4176 20 the the DT cord-015021-pol2qm74 4176 21 marker marker NN cord-015021-pol2qm74 4176 22 / / SYM cord-015021-pol2qm74 4176 23 cytoldne cytoldne NN cord-015021-pol2qm74 4176 24 measurements measurement NNS cord-015021-pol2qm74 4176 25 by by IN cord-015021-pol2qm74 4176 26 simple simple JJ cord-015021-pol2qm74 4176 27 multiplication multiplication NN cord-015021-pol2qm74 4176 28 . . . cord-015021-pol2qm74 4177 1 Anaesthesia anaesthesia NN cord-015021-pol2qm74 4177 2 and and CC cord-015021-pol2qm74 4177 3 pre pre JJ cord-015021-pol2qm74 4177 4 - - JJ cord-015021-pol2qm74 4177 5 ineision ineision JJ cord-015021-pol2qm74 4177 6 maneuvers maneuver NNS cord-015021-pol2qm74 4177 7 did do VBD cord-015021-pol2qm74 4177 8 not not RB cord-015021-pol2qm74 4177 9 significantly significantly RB cord-015021-pol2qm74 4177 10 change change VB cord-015021-pol2qm74 4177 11 cell cell NN cord-015021-pol2qm74 4177 12 marker marker NN cord-015021-pol2qm74 4177 13 or or CC cord-015021-pol2qm74 4177 14 cytokine cytokine NN cord-015021-pol2qm74 4177 15 levels level NNS cord-015021-pol2qm74 4177 16 in in IN cord-015021-pol2qm74 4177 17 either either CC cord-015021-pol2qm74 4177 18 surgical surgical JJ cord-015021-pol2qm74 4177 19 approach approach NN cord-015021-pol2qm74 4177 20 as as IN cord-015021-pol2qm74 4177 21 compared compare VBN cord-015021-pol2qm74 4177 22 to to IN cord-015021-pol2qm74 4177 23 24 24 CD cord-015021-pol2qm74 4177 24 h h NN cord-015021-pol2qm74 4177 25 before before IN cord-015021-pol2qm74 4177 26 surgery surgery NN cord-015021-pol2qm74 4177 27 . . . cord-015021-pol2qm74 4178 1 2 2 LS cord-015021-pol2qm74 4178 2 h h NN cord-015021-pol2qm74 4178 3 after after IN cord-015021-pol2qm74 4178 4 incision incision NN cord-015021-pol2qm74 4178 5 the the DT cord-015021-pol2qm74 4178 6 TrA TrA NNP cord-015021-pol2qm74 4178 7 index index NN cord-015021-pol2qm74 4178 8 in in IN cord-015021-pol2qm74 4178 9 open open JJ cord-015021-pol2qm74 4178 10 cholecystectomy cholecystectomy NN cord-015021-pol2qm74 4178 11 showed show VBD cord-015021-pol2qm74 4178 12 a a DT cord-015021-pol2qm74 4178 13 distinct distinct JJ cord-015021-pol2qm74 4178 14 22 22 CD cord-015021-pol2qm74 4178 15 - - SYM cord-015021-pol2qm74 4178 16 37 37 CD cord-015021-pol2qm74 4178 17 fold fold JJ cord-015021-pol2qm74 4178 18 increase increase NN cord-015021-pol2qm74 4178 19 , , , cord-015021-pol2qm74 4178 20 whereas whereas IN cord-015021-pol2qm74 4178 21 in in IN cord-015021-pol2qm74 4178 22 laparoseopic laparoseopic NNP cord-015021-pol2qm74 4178 23 surgery surgery NN cord-015021-pol2qm74 4178 24 a a DT cord-015021-pol2qm74 4178 25 mere mere JJ cord-015021-pol2qm74 4178 26 2 2 CD cord-015021-pol2qm74 4178 27 - - SYM cord-015021-pol2qm74 4178 28 3 3 CD cord-015021-pol2qm74 4178 29 fold fold JJ cord-015021-pol2qm74 4178 30 increase increase NN cord-015021-pol2qm74 4178 31 was be VBD cord-015021-pol2qm74 4178 32 noted note VBN cord-015021-pol2qm74 4178 33 . . . cord-015021-pol2qm74 4179 1 24 24 CD cord-015021-pol2qm74 4179 2 h h NN cord-015021-pol2qm74 4179 3 after after IN cord-015021-pol2qm74 4179 4 incision incision NN cord-015021-pol2qm74 4179 5 , , , cord-015021-pol2qm74 4179 6 the the DT cord-015021-pol2qm74 4179 7 TrA tra NN cord-015021-pol2qm74 4179 8 - - HYPH cord-015021-pol2qm74 4179 9 index index NN cord-015021-pol2qm74 4179 10 returned return VBD cord-015021-pol2qm74 4179 11 to to IN cord-015021-pol2qm74 4179 12 near near IN cord-015021-pol2qm74 4179 13 pre pre JJ cord-015021-pol2qm74 4179 14 - - JJ cord-015021-pol2qm74 4179 15 surgery surgery JJ cord-015021-pol2qm74 4179 16 levels level NNS cord-015021-pol2qm74 4179 17 . . . cord-015021-pol2qm74 4180 1 In in IN cord-015021-pol2qm74 4180 2 conclusion conclusion NN cord-015021-pol2qm74 4180 3 , , , cord-015021-pol2qm74 4180 4 our -PRON- PRP$ cord-015021-pol2qm74 4180 5 results result NNS cord-015021-pol2qm74 4180 6 demonstrate demonstrate VBP cord-015021-pol2qm74 4180 7 that that IN cord-015021-pol2qm74 4180 8 changes change NNS cord-015021-pol2qm74 4180 9 in in IN cord-015021-pol2qm74 4180 10 cell cell NN cord-015021-pol2qm74 4180 11 surface surface NN cord-015021-pol2qm74 4180 12 markers marker NNS cord-015021-pol2qm74 4180 13 and and CC cord-015021-pol2qm74 4180 14 cytokines cytokine NNS cord-015021-pol2qm74 4180 15 can can MD cord-015021-pol2qm74 4180 16 help help VB cord-015021-pol2qm74 4180 17 evaluate evaluate VB cord-015021-pol2qm74 4180 18 the the DT cord-015021-pol2qm74 4180 19 magnitude magnitude NN cord-015021-pol2qm74 4180 20 of of IN cord-015021-pol2qm74 4180 21 tissue tissue NN cord-015021-pol2qm74 4180 22 trauma trauma NN cord-015021-pol2qm74 4180 23 in in IN cord-015021-pol2qm74 4180 24 diffei'ent diffei'ent JJ cord-015021-pol2qm74 4180 25 surgical surgical JJ cord-015021-pol2qm74 4180 26 approaches approach NNS cord-015021-pol2qm74 4180 27 . . . cord-015021-pol2qm74 4181 1 The the DT cord-015021-pol2qm74 4181 2 relationship relationship NN cord-015021-pol2qm74 4181 3 between between IN cord-015021-pol2qm74 4181 4 lymphocyte lymphocyte NN cord-015021-pol2qm74 4181 5 subpopulation subpopulation NN cord-015021-pol2qm74 4181 6 changes change NNS cord-015021-pol2qm74 4181 7 after after IN cord-015021-pol2qm74 4181 8 thermal thermal JJ cord-015021-pol2qm74 4181 9 injury injury NN cord-015021-pol2qm74 4181 10 and and CC cord-015021-pol2qm74 4181 11 the the DT cord-015021-pol2qm74 4181 12 increased increase VBN cord-015021-pol2qm74 4181 13 susceptibility susceptibility NN cord-015021-pol2qm74 4181 14 of of IN cord-015021-pol2qm74 4181 15 burned burn VBN cord-015021-pol2qm74 4181 16 patients patient NNS cord-015021-pol2qm74 4181 17 to to IN cord-015021-pol2qm74 4181 18 infection infection NN cord-015021-pol2qm74 4181 19 is be VBZ cord-015021-pol2qm74 4181 20 unclear unclear JJ cord-015021-pol2qm74 4181 21 . . . cord-015021-pol2qm74 4182 1 In in IN cord-015021-pol2qm74 4182 2 this this DT cord-015021-pol2qm74 4182 3 study study NN cord-015021-pol2qm74 4182 4 , , , cord-015021-pol2qm74 4182 5 we -PRON- PRP cord-015021-pol2qm74 4182 6 have have VBP cord-015021-pol2qm74 4182 7 attempted attempt VBN cord-015021-pol2qm74 4182 8 to to TO cord-015021-pol2qm74 4182 9 correlate correlate VB cord-015021-pol2qm74 4182 10 such such JJ cord-015021-pol2qm74 4182 11 subpopulation subpopulation NN cord-015021-pol2qm74 4182 12 changes change NNS cord-015021-pol2qm74 4182 13 with with IN cord-015021-pol2qm74 4182 14 the the DT cord-015021-pol2qm74 4182 15 presence presence NN cord-015021-pol2qm74 4182 16 of of IN cord-015021-pol2qm74 4182 17 infection infection NN cord-015021-pol2qm74 4182 18 in in IN cord-015021-pol2qm74 4182 19 burned burn VBN cord-015021-pol2qm74 4182 20 patients patient NNS cord-015021-pol2qm74 4182 21 . . . cord-015021-pol2qm74 4183 1 Peripberal peripberal JJ cord-015021-pol2qm74 4183 2 blood blood NN cord-015021-pol2qm74 4183 3 from from IN cord-015021-pol2qm74 4183 4 19 19 CD cord-015021-pol2qm74 4183 5 patients patient NNS cord-015021-pol2qm74 4183 6 was be VBD cord-015021-pol2qm74 4183 7 monitored monitor VBN cord-015021-pol2qm74 4183 8 for for IN cord-015021-pol2qm74 4183 9 lymphocyte lymphocyte NN cord-015021-pol2qm74 4183 10 subpopulation subpopulation NN cord-015021-pol2qm74 4183 11 changes change VBZ cord-015021-pol2qm74 4183 12 three three CD cord-015021-pol2qm74 4183 13 times time NNS cord-015021-pol2qm74 4183 14 weekly weekly JJ cord-015021-pol2qm74 4183 15 for for IN cord-015021-pol2qm74 4183 16 three three CD cord-015021-pol2qm74 4183 17 weeks week NNS cord-015021-pol2qm74 4183 18 postburn postburn NN cord-015021-pol2qm74 4183 19 and and CC cord-015021-pol2qm74 4183 20 weekly weekly NN cord-015021-pol2qm74 4183 21 thereafter thereafter RB cord-015021-pol2qm74 4183 22 for for IN cord-015021-pol2qm74 4183 23 three three CD cord-015021-pol2qm74 4183 24 additional additional JJ cord-015021-pol2qm74 4183 25 weeks week NNS cord-015021-pol2qm74 4183 26 . . . cord-015021-pol2qm74 4184 1 Mean mean VB cord-015021-pol2qm74 4184 2 bum bum JJ cord-015021-pol2qm74 4184 3 size size NN cord-015021-pol2qm74 4184 4 was be VBD cord-015021-pol2qm74 4184 5 44.7 44.7 CD cord-015021-pol2qm74 4184 6 % % NN cord-015021-pol2qm74 4184 7 ( ( -LRB- cord-015021-pol2qm74 4184 8 range range NN cord-015021-pol2qm74 4184 9 24%-84 24%-84 CD cord-015021-pol2qm74 4184 10 % % NN cord-015021-pol2qm74 4184 11 ) ) -RRB- cord-015021-pol2qm74 4184 12 of of IN cord-015021-pol2qm74 4184 13 total total JJ cord-015021-pol2qm74 4184 14 body body NN cord-015021-pol2qm74 4184 15 surface surface NN cord-015021-pol2qm74 4184 16 and and CC cord-015021-pol2qm74 4184 17 mean mean VB cord-015021-pol2qm74 4184 18 age age NN cord-015021-pol2qm74 4184 19 was be VBD cord-015021-pol2qm74 4184 20 38 38 CD cord-015021-pol2qm74 4184 21 years year NNS cord-015021-pol2qm74 4184 22 . . . cord-015021-pol2qm74 4185 1 Infection infection NN cord-015021-pol2qm74 4185 2 was be VBD cord-015021-pol2qm74 4185 3 diagnosed diagnose VBN cord-015021-pol2qm74 4185 4 by by IN cord-015021-pol2qm74 4185 5 carefully carefully RB cord-015021-pol2qm74 4185 6 defined define VBN cord-015021-pol2qm74 4185 7 clinical clinical JJ cord-015021-pol2qm74 4185 8 and and CC cord-015021-pol2qm74 4185 9 laboratory laboratory NN cord-015021-pol2qm74 4185 10 criteria criterion NNS cord-015021-pol2qm74 4185 11 and and CC cord-015021-pol2qm74 4185 12 its -PRON- PRP$ cord-015021-pol2qm74 4185 13 presence presence NN cord-015021-pol2qm74 4185 14 or or CC cord-015021-pol2qm74 4185 15 absence absence NN cord-015021-pol2qm74 4185 16 noted note VBD cord-015021-pol2qm74 4185 17 each each DT cord-015021-pol2qm74 4185 18 time time NN cord-015021-pol2qm74 4185 19 blood blood NN cord-015021-pol2qm74 4185 20 was be VBD cord-015021-pol2qm74 4185 21 drawn draw VBN cord-015021-pol2qm74 4185 22 . . . cord-015021-pol2qm74 4186 1 Samples sample NNS cord-015021-pol2qm74 4186 2 taken take VBN cord-015021-pol2qm74 4186 3 when when WRB cord-015021-pol2qm74 4186 4 patients patient NNS cord-015021-pol2qm74 4186 5 had have VBD cord-015021-pol2qm74 4186 6 wound wind VBN cord-015021-pol2qm74 4186 7 infection infection NN cord-015021-pol2qm74 4186 8 , , , cord-015021-pol2qm74 4186 9 bacteremia bacteremia NN cord-015021-pol2qm74 4186 10 , , , cord-015021-pol2qm74 4186 11 or or CC cord-015021-pol2qm74 4186 12 pneumonia pneumonia NN cord-015021-pol2qm74 4186 13 were be VBD cord-015021-pol2qm74 4186 14 compared compare VBN cord-015021-pol2qm74 4186 15 with with IN cord-015021-pol2qm74 4186 16 samples sample NNS cord-015021-pol2qm74 4186 17 taken take VBN cord-015021-pol2qm74 4186 18 in in IN cord-015021-pol2qm74 4186 19 the the DT cord-015021-pol2qm74 4186 20 absence absence NN cord-015021-pol2qm74 4186 21 of of IN cord-015021-pol2qm74 4186 22 systemic systemic JJ cord-015021-pol2qm74 4186 23 infection infection NN cord-015021-pol2qm74 4186 24 . . . cord-015021-pol2qm74 4187 1 Whole whole JJ cord-015021-pol2qm74 4187 2 blood blood NN cord-015021-pol2qm74 4187 3 samples sample NNS cord-015021-pol2qm74 4187 4 were be VBD cord-015021-pol2qm74 4187 5 stained stain VBN cord-015021-pol2qm74 4187 6 with with IN cord-015021-pol2qm74 4187 7 four four CD cord-015021-pol2qm74 4187 8 monoclonal monoclonal JJ cord-015021-pol2qm74 4187 9 antibodies antibody NNS cord-015021-pol2qm74 4187 10 , , , cord-015021-pol2qm74 4187 11 the the DT cord-015021-pol2qm74 4187 12 red red JJ cord-015021-pol2qm74 4187 13 blood blood NN cord-015021-pol2qm74 4187 14 cells cell NNS cord-015021-pol2qm74 4187 15 lysed lyse VBN cord-015021-pol2qm74 4187 16 and and CC cord-015021-pol2qm74 4187 17 the the DT cord-015021-pol2qm74 4187 18 leukocytes leukocyte NNS cord-015021-pol2qm74 4187 19 fixed fix VBN cord-015021-pol2qm74 4187 20 and and CC cord-015021-pol2qm74 4187 21 analyzed analyze VBN cord-015021-pol2qm74 4187 22 by by IN cord-015021-pol2qm74 4187 23 flow flow NN cord-015021-pol2qm74 4187 24 cytometry cytometry NN cord-015021-pol2qm74 4187 25 . . . cord-015021-pol2qm74 4188 1 For for IN cord-015021-pol2qm74 4188 2 each each DT cord-015021-pol2qm74 4188 3 patient patient JJ cord-015021-pol2qm74 4188 4 sample sample NN cord-015021-pol2qm74 4188 5 , , , cord-015021-pol2qm74 4188 6 the the DT cord-015021-pol2qm74 4188 7 proportion proportion NN cord-015021-pol2qm74 4188 8 of of IN cord-015021-pol2qm74 4188 9 lymphocytes lymphocyte NNS cord-015021-pol2qm74 4188 10 falling fall VBG cord-015021-pol2qm74 4188 11 within within IN cord-015021-pol2qm74 4188 12 the the DT cord-015021-pol2qm74 4188 13 light light JJ cord-015021-pol2qm74 4188 14 scatter scatter NN cord-015021-pol2qm74 4188 15 gates gate NNS cord-015021-pol2qm74 4188 16 was be VBD cord-015021-pol2qm74 4188 17 determined determine VBN cord-015021-pol2qm74 4188 18 as as IN cord-015021-pol2qm74 4188 19 the the DT cord-015021-pol2qm74 4188 20 percentage percentage NN cord-015021-pol2qm74 4188 21 of of IN cord-015021-pol2qm74 4188 22 cells cell NNS cord-015021-pol2qm74 4188 23 negative negative JJ cord-015021-pol2qm74 4188 24 for for IN cord-015021-pol2qm74 4188 25 CD14 CD14 NNP cord-015021-pol2qm74 4188 26 and and CC cord-015021-pol2qm74 4188 27 most most RBS cord-015021-pol2qm74 4188 28 strongly strongly RB cord-015021-pol2qm74 4188 29 positive positive JJ cord-015021-pol2qm74 4188 30 for for IN cord-015021-pol2qm74 4188 31 CD45 CD45 NNP cord-015021-pol2qm74 4188 32 . . . cord-015021-pol2qm74 4189 1 This this DT cord-015021-pol2qm74 4189 2 percentage percentage NN cord-015021-pol2qm74 4189 3 was be VBD cord-015021-pol2qm74 4189 4 used use VBN cord-015021-pol2qm74 4189 5 to to TO cord-015021-pol2qm74 4189 6 correct correct VB cord-015021-pol2qm74 4189 7 each each DT cord-015021-pol2qm74 4189 8 sample sample NN cord-015021-pol2qm74 4189 9 for for IN cord-015021-pol2qm74 4189 10 the the DT cord-015021-pol2qm74 4189 11 presence presence NN cord-015021-pol2qm74 4189 12 of of IN cord-015021-pol2qm74 4189 13 debris debris NN cord-015021-pol2qm74 4189 14 or or CC cord-015021-pol2qm74 4189 15 nonlymphocytic nonlymphocytic NN cord-015021-pol2qm74 4189 16 cells cell NNS cord-015021-pol2qm74 4189 17 . . . cord-015021-pol2qm74 4190 1 The the DT cord-015021-pol2qm74 4190 2 proportion proportion NN cord-015021-pol2qm74 4190 3 of of IN cord-015021-pol2qm74 4190 4 CD4 CD4 NNP cord-015021-pol2qm74 4190 5 and and CC cord-015021-pol2qm74 4190 6 CD8 CD8 NNP cord-015021-pol2qm74 4190 7 positive positive JJ cord-015021-pol2qm74 4190 8 cells cell NNS cord-015021-pol2qm74 4190 9 was be VBD cord-015021-pol2qm74 4190 10 slightly slightly RB cord-015021-pol2qm74 4190 11 greatc~ greatc~ NNS cord-015021-pol2qm74 4190 12 in in IN cord-015021-pol2qm74 4190 13 the the DT cord-015021-pol2qm74 4190 14 samples sample NNS cord-015021-pol2qm74 4190 15 from from IN cord-015021-pol2qm74 4190 16 infected infected JJ cord-015021-pol2qm74 4190 17 patients patient NNS cord-015021-pol2qm74 4190 18 , , , cord-015021-pol2qm74 4190 19 while while IN cord-015021-pol2qm74 4190 20 the the DT cord-015021-pol2qm74 4190 21 proportion proportion NN cord-015021-pol2qm74 4190 22 of of IN cord-015021-pol2qm74 4190 23 B b NN cord-015021-pol2qm74 4190 24 cells cell NNS cord-015021-pol2qm74 4190 25 ( ( -LRB- cord-015021-pol2qm74 4190 26 CD20 cd20 NN cord-015021-pol2qm74 4190 27 + + CC cord-015021-pol2qm74 4190 28 ) ) -RRB- cord-015021-pol2qm74 4190 29 was be VBD cord-015021-pol2qm74 4190 30 unchanged unchanged JJ cord-015021-pol2qm74 4190 31 and and CC cord-015021-pol2qm74 4190 32 NK NK NNP cord-015021-pol2qm74 4190 33 ( ( -LRB- cord-015021-pol2qm74 4190 34 CD16 CD16 NNP cord-015021-pol2qm74 4190 35 + + SYM cord-015021-pol2qm74 4190 36 ) ) -RRB- cord-015021-pol2qm74 4190 37 cells cell NNS cord-015021-pol2qm74 4190 38 were be VBD cord-015021-pol2qm74 4190 39 decreased decrease VBN cord-015021-pol2qm74 4190 40 by by IN cord-015021-pol2qm74 4190 41 ahnos ahnos NNP cord-015021-pol2qm74 4190 42 [ [ -LRB- cord-015021-pol2qm74 4190 43 50 50 CD cord-015021-pol2qm74 4190 44 % % NN cord-015021-pol2qm74 4190 45 compared compare VBN cord-015021-pol2qm74 4190 46 to to IN cord-015021-pol2qm74 4190 47 sampie~ sampie~ NNP cord-015021-pol2qm74 4190 48 li'om li'om NNP cord-015021-pol2qm74 4190 49 uuiuleclcd uuiuleclcd NNP cord-015021-pol2qm74 4190 50 patients patient NNS cord-015021-pol2qm74 4190 51 . . . cord-015021-pol2qm74 4191 1 The the DT cord-015021-pol2qm74 4191 2 percentage percentage NN cord-015021-pol2qm74 4191 3 of of IN cord-015021-pol2qm74 4191 4 cells cell NNS cord-015021-pol2qm74 4191 5 positive positive JJ cord-015021-pol2qm74 4191 6 for for IN cord-015021-pol2qm74 4191 7 CDIlb CDIlb NNP cord-015021-pol2qm74 4191 8 ( ( -LRB- cord-015021-pol2qm74 4191 9 c~ c~ IN cord-015021-pol2qm74 4191 10 integrin integrin NN cord-015021-pol2qm74 4191 11 ) ) -RRB- cord-015021-pol2qm74 4191 12 decreased decrease VBD cord-015021-pol2qm74 4191 13 sharply sharply RB cord-015021-pol2qm74 4191 14 and and CC cord-015021-pol2qm74 4191 15 CD4RO cd4ro JJ cord-015021-pol2qm74 4191 16 ( ( -LRB- cord-015021-pol2qm74 4191 17 memory memory NN cord-015021-pol2qm74 4191 18 cells cell NNS cord-015021-pol2qm74 4191 19 ) ) -RRB- cord-015021-pol2qm74 4191 20 decreased decrease VBD cord-015021-pol2qm74 4191 21 slightly slightly RB cord-015021-pol2qm74 4191 22 in in IN cord-015021-pol2qm74 4191 23 samples sample NNS cord-015021-pol2qm74 4191 24 from from IN cord-015021-pol2qm74 4191 25 infected infected JJ cord-015021-pol2qm74 4191 26 patients patient NNS cord-015021-pol2qm74 4191 27 while while IN cord-015021-pol2qm74 4191 28 the the DT cord-015021-pol2qm74 4191 29 expression expression NN cord-015021-pol2qm74 4191 30 of of IN cord-015021-pol2qm74 4191 31 the the DT cord-015021-pol2qm74 4191 32 lymphocyte lymphocyte NN cord-015021-pol2qm74 4191 33 homing homing NN cord-015021-pol2qm74 4191 34 receptor receptor NN cord-015021-pol2qm74 4191 35 and and CC cord-015021-pol2qm74 4191 36 CD29 CD29 NNP cord-015021-pol2qm74 4191 37 were be VBD cord-015021-pol2qm74 4191 38 unchanged unchanged JJ cord-015021-pol2qm74 4191 39 . . . cord-015021-pol2qm74 4192 1 CD25 cd25 JJ cord-015021-pol2qm74 4192 2 ( ( -LRB- cord-015021-pol2qm74 4192 3 IL2 IL2 NNP cord-015021-pol2qm74 4192 4 receptor receptor NN cord-015021-pol2qm74 4192 5 ) ) -RRB- cord-015021-pol2qm74 4192 6 and and CC cord-015021-pol2qm74 4192 7 CD69 CD69 NNP cord-015021-pol2qm74 4192 8 ( ( -LRB- cord-015021-pol2qm74 4192 9 early early JJ cord-015021-pol2qm74 4192 10 activation activation NN cord-015021-pol2qm74 4192 11 marker marker NN cord-015021-pol2qm74 4192 12 ) ) -RRB- cord-015021-pol2qm74 4192 13 were be VBD cord-015021-pol2qm74 4192 14 significantly significantly RB cord-015021-pol2qm74 4192 15 increased increase VBN cord-015021-pol2qm74 4192 16 in in IN cord-015021-pol2qm74 4192 17 the the DT cord-015021-pol2qm74 4192 18 samples sample NNS cord-015021-pol2qm74 4192 19 from from IN cord-015021-pol2qm74 4192 20 the the DT cord-015021-pol2qm74 4192 21 infected infected JJ cord-015021-pol2qm74 4192 22 patients patient NNS cord-015021-pol2qm74 4192 23 while while IN cord-015021-pol2qm74 4192 24 HLADR HLADR NNP cord-015021-pol2qm74 4192 25 was be VBD cord-015021-pol2qm74 4192 26 unchanged unchanged JJ cord-015021-pol2qm74 4192 27 . . . cord-015021-pol2qm74 4193 1 These these DT cord-015021-pol2qm74 4193 2 changes change NNS cord-015021-pol2qm74 4193 3 in in IN cord-015021-pol2qm74 4193 4 lymphocyte lymphocyte NN cord-015021-pol2qm74 4193 5 phenotype phenotype NN cord-015021-pol2qm74 4193 6 correlate correlate VBP cord-015021-pol2qm74 4193 7 with with IN cord-015021-pol2qm74 4193 8 the the DT cord-015021-pol2qm74 4193 9 presence presence NN cord-015021-pol2qm74 4193 10 of of IN cord-015021-pol2qm74 4193 11 infection infection NN cord-015021-pol2qm74 4193 12 . . . cord-015021-pol2qm74 4194 1 If if IN cord-015021-pol2qm74 4194 2 they -PRON- PRP cord-015021-pol2qm74 4194 3 closely closely RB cord-015021-pol2qm74 4194 4 precede precede VBP cord-015021-pol2qm74 4194 5 or or CC cord-015021-pol2qm74 4194 6 occur occur VBP cord-015021-pol2qm74 4194 7 during during IN cord-015021-pol2qm74 4194 8 the the DT cord-015021-pol2qm74 4194 9 early early JJ cord-015021-pol2qm74 4194 10 development development NN cord-015021-pol2qm74 4194 11 of of IN cord-015021-pol2qm74 4194 12 infection infection NN cord-015021-pol2qm74 4194 13 they -PRON- PRP cord-015021-pol2qm74 4194 14 may may MD cord-015021-pol2qm74 4194 15 be be VB cord-015021-pol2qm74 4194 16 valuable valuable JJ cord-015021-pol2qm74 4194 17 clues clue NNS cord-015021-pol2qm74 4194 18 to to IN cord-015021-pol2qm74 4194 19 the the DT cord-015021-pol2qm74 4194 20 mechanism mechanism NN cord-015021-pol2qm74 4194 21 of of IN cord-015021-pol2qm74 4194 22 susceptibility susceptibility NN cord-015021-pol2qm74 4194 23 following follow VBG cord-015021-pol2qm74 4194 24 thermal thermal JJ cord-015021-pol2qm74 4194 25 injury injury NN cord-015021-pol2qm74 4194 26 . . . cord-015021-pol2qm74 4195 1 Trauma trauma NN cord-015021-pol2qm74 4195 2 patients patient NNS cord-015021-pol2qm74 4195 3 are be VBP cord-015021-pol2qm74 4195 4 subjected subject VBN cord-015021-pol2qm74 4195 5 to to IN cord-015021-pol2qm74 4195 6 an an DT cord-015021-pol2qm74 4195 7 immediate immediate JJ cord-015021-pol2qm74 4195 8 massive massive JJ cord-015021-pol2qm74 4195 9 impact impact NN cord-015021-pol2qm74 4195 10 on on IN cord-015021-pol2qm74 4195 11 their -PRON- PRP$ cord-015021-pol2qm74 4195 12 host host NN cord-015021-pol2qm74 4195 13 defense defense NN cord-015021-pol2qm74 4195 14 integrity integrity NN cord-015021-pol2qm74 4195 15 due due IN cord-015021-pol2qm74 4195 16 to to IN cord-015021-pol2qm74 4195 17 the the DT cord-015021-pol2qm74 4195 18 combined combined JJ cord-015021-pol2qm74 4195 19 effect effect NN cord-015021-pol2qm74 4195 20 of of IN cord-015021-pol2qm74 4195 21 tissue tissue NN cord-015021-pol2qm74 4195 22 trauma trauma NN cord-015021-pol2qm74 4195 23 , , , cord-015021-pol2qm74 4195 24 shock shock NN cord-015021-pol2qm74 4195 25 and and CC cord-015021-pol2qm74 4195 26 endotoxemia endotoxemia NN cord-015021-pol2qm74 4195 27 . . . cord-015021-pol2qm74 4196 1 Cytoldnes cytoldne NNS cord-015021-pol2qm74 4196 2 are be VBP cord-015021-pol2qm74 4196 3 playing play VBG cord-015021-pol2qm74 4196 4 a a DT cord-015021-pol2qm74 4196 5 crucial crucial JJ cord-015021-pol2qm74 4196 6 role role NN cord-015021-pol2qm74 4196 7 within within IN cord-015021-pol2qm74 4196 8 the the DT cord-015021-pol2qm74 4196 9 course course NN cord-015021-pol2qm74 4196 10 of of IN cord-015021-pol2qm74 4196 11 an an DT cord-015021-pol2qm74 4196 12 impaired impaired JJ cord-015021-pol2qm74 4196 13 cell cell NN cord-015021-pol2qm74 4196 14 mediated mediate VBN cord-015021-pol2qm74 4196 15 immune immune JJ cord-015021-pol2qm74 4196 16 response response NN cord-015021-pol2qm74 4196 17 ( ( -LRB- cord-015021-pol2qm74 4196 18 CMI CMI NNP cord-015021-pol2qm74 4196 19 ) ) -RRB- cord-015021-pol2qm74 4196 20 resulting result VBG cord-015021-pol2qm74 4196 21 from from IN cord-015021-pol2qm74 4196 22 a a DT cord-015021-pol2qm74 4196 23 disruption disruption NN cord-015021-pol2qm74 4196 24 of of IN cord-015021-pol2qm74 4196 25 intact intact JJ cord-015021-pol2qm74 4196 26 M%/Tcell M%/Tcell NNP cord-015021-pol2qm74 4196 27 interaction interaction NN cord-015021-pol2qm74 4196 28 . . . cord-015021-pol2qm74 4197 1 The the DT cord-015021-pol2qm74 4197 2 current current JJ cord-015021-pol2qm74 4197 3 study study NN cord-015021-pol2qm74 4197 4 was be VBD cord-015021-pol2qm74 4197 5 undertaken undertake VBN cord-015021-pol2qm74 4197 6 to to TO cord-015021-pol2qm74 4197 7 further further RB cord-015021-pol2qm74 4197 8 elucidate elucidate VB cord-015021-pol2qm74 4197 9 the the DT cord-015021-pol2qm74 4197 10 mechanisms mechanism NNS cord-015021-pol2qm74 4197 11 of of IN cord-015021-pol2qm74 4197 12 dysfimctional dysfimctional JJ cord-015021-pol2qm74 4197 13 CMI CMI NNP cord-015021-pol2qm74 4197 14 following follow VBG cord-015021-pol2qm74 4197 15 major major JJ cord-015021-pol2qm74 4197 16 burn burn NN cord-015021-pol2qm74 4197 17 and and CC cord-015021-pol2qm74 4197 18 mechanical mechanical JJ cord-015021-pol2qm74 4197 19 trauma trauma NN cord-015021-pol2qm74 4197 20 -via -via , cord-015021-pol2qm74 4197 21 comparative comparative JJ cord-015021-pol2qm74 4197 22 analysis analysis NN cord-015021-pol2qm74 4197 23 of of IN cord-015021-pol2qm74 4197 24 mRNA mRNA NNP cord-015021-pol2qm74 4197 25 expression expression NN cord-015021-pol2qm74 4197 26 and and CC cord-015021-pol2qm74 4197 27 protein protein NN cord-015021-pol2qm74 4197 28 release release NN cord-015021-pol2qm74 4197 29 . . . cord-015021-pol2qm74 4198 1 The the DT cord-015021-pol2qm74 4198 2 major major JJ cord-015021-pol2qm74 4198 3 regulatory regulatory JJ cord-015021-pol2qm74 4198 4 levels level NNS cord-015021-pol2qm74 4198 5 for for IN cord-015021-pol2qm74 4198 6 different different JJ cord-015021-pol2qm74 4198 7 cytokines cytokine NNS cord-015021-pol2qm74 4198 8 were be VBD cord-015021-pol2qm74 4198 9 determined determine VBN cord-015021-pol2qm74 4198 10 in in IN cord-015021-pol2qm74 4198 11 mitogen mitogen NNP cord-015021-pol2qm74 4198 12 , , , cord-015021-pol2qm74 4198 13 respectively respectively RB cord-015021-pol2qm74 4198 14 LPS lp NNS cord-015021-pol2qm74 4198 15 stimulated stimulate VBD cord-015021-pol2qm74 4198 16 peripheral peripheral JJ cord-015021-pol2qm74 4198 17 blood blood NN cord-015021-pol2qm74 4198 18 mononuclear mononuclear JJ cord-015021-pol2qm74 4198 19 cell cell NN cord-015021-pol2qm74 4198 20 ( ( -LRB- cord-015021-pol2qm74 4198 21 PBMC PBMC NNP cord-015021-pol2qm74 4198 22 ) ) -RRB- cord-015021-pol2qm74 4198 23 cultures culture NNS cord-015021-pol2qm74 4198 24 of of IN cord-015021-pol2qm74 4198 25 trauma trauma NN cord-015021-pol2qm74 4198 26 patients patient NNS cord-015021-pol2qm74 4198 27 on on IN cord-015021-pol2qm74 4198 28 consecutive consecutive JJ cord-015021-pol2qm74 4198 29 days day NNS cord-015021-pol2qm74 4198 30 ( ( -LRB- cord-015021-pol2qm74 4198 31 13 13 CD cord-015021-pol2qm74 4198 32 ) ) -RRB- cord-015021-pol2qm74 4198 33 t t NN cord-015021-pol2qm74 4198 34 , , , cord-015021-pol2qm74 4198 35 3 3 CD cord-015021-pol2qm74 4198 36 , , , cord-015021-pol2qm74 4198 37 5 5 CD cord-015021-pol2qm74 4198 38 , , , cord-015021-pol2qm74 4198 39 7 7 CD cord-015021-pol2qm74 4198 40 and and CC cord-015021-pol2qm74 4198 41 10 10 CD cord-015021-pol2qm74 4198 42 post post NN cord-015021-pol2qm74 4198 43 injury injury NN cord-015021-pol2qm74 4198 44 . . . cord-015021-pol2qm74 4199 1 We -PRON- PRP cord-015021-pol2qm74 4199 2 analyzed analyze VBD cord-015021-pol2qm74 4199 3 the the DT cord-015021-pol2qm74 4199 4 cumulative cumulative JJ cord-015021-pol2qm74 4199 5 data datum NNS cord-015021-pol2qm74 4199 6 for for IN cord-015021-pol2qm74 4199 7 Interleukin-1 Interleukin-1 NNP cord-015021-pol2qm74 4199 8 beta beta NN cord-015021-pol2qm74 4199 9 ( ( -LRB- cord-015021-pol2qm74 4199 10 IL IL NNP cord-015021-pol2qm74 4199 11 - - HYPH cord-015021-pol2qm74 4199 12 I[3 I[3 NNP cord-015021-pol2qm74 4199 13 ) ) -RRB- cord-015021-pol2qm74 4199 14 , , . cord-015021-pol2qm74 4200 1 IL-2 IL-2 NNP cord-015021-pol2qm74 4200 2 , , , cord-015021-pol2qm74 4200 3 IL-8 IL-8 NNP cord-015021-pol2qm74 4200 4 as as RB cord-015021-pol2qm74 4200 5 well well RB cord-015021-pol2qm74 4200 6 as as IN cord-015021-pol2qm74 4200 7 tumor tumor NN cord-015021-pol2qm74 4200 8 necrosis necrosis NN cord-015021-pol2qm74 4200 9 factor factor NN cord-015021-pol2qm74 4200 10 alpha alpha NN cord-015021-pol2qm74 4200 11 ( ( -LRB- cord-015021-pol2qm74 4200 12 TNF-~ TNF-~ NNP cord-015021-pol2qm74 4200 13 ) ) -RRB- cord-015021-pol2qm74 4200 14 and and CC cord-015021-pol2qm74 4200 15 saw see VBD cord-015021-pol2qm74 4200 16 a a DT cord-015021-pol2qm74 4200 17 considerable considerable JJ cord-015021-pol2qm74 4200 18 impairment impairment NN cord-015021-pol2qm74 4200 19 of of IN cord-015021-pol2qm74 4200 20 the the DT cord-015021-pol2qm74 4200 21 protein protein NN cord-015021-pol2qm74 4200 22 release release NN cord-015021-pol2qm74 4200 23 in in IN cord-015021-pol2qm74 4200 24 the the DT cord-015021-pol2qm74 4200 25 stimulated stimulated JJ cord-015021-pol2qm74 4200 26 PBMC PBMC NNP cord-015021-pol2qm74 4200 27 cultures culture NNS cord-015021-pol2qm74 4200 28 until until IN cord-015021-pol2qm74 4200 29 D5 D5 NNP cord-015021-pol2qm74 4200 30 post post NN cord-015021-pol2qm74 4200 31 - - JJ cord-015021-pol2qm74 4200 32 trauma trauma NN cord-015021-pol2qm74 4200 33 and and CC cord-015021-pol2qm74 4200 34 recovery recovery NN cord-015021-pol2qm74 4200 35 thereafter thereafter RB cord-015021-pol2qm74 4200 36 . . . cord-015021-pol2qm74 4201 1 * * NFP cord-015021-pol2qm74 4201 2 p p XX cord-015021-pol2qm74 4201 3 < < XX cord-015021-pol2qm74 4201 4 0.05 0.05 CD cord-015021-pol2qm74 4201 5 , , , cord-015021-pol2qm74 4202 1 * * NFP cord-015021-pol2qm74 4202 2 * * NFP cord-015021-pol2qm74 4202 3 p p XX cord-015021-pol2qm74 4202 4 < < XX cord-015021-pol2qm74 4202 5 0.01 0.01 CD cord-015021-pol2qm74 4202 6 vs vs IN cord-015021-pol2qm74 4202 7 control control NN cord-015021-pol2qm74 4202 8 Comparing compare VBG cord-015021-pol2qm74 4202 9 the the DT cord-015021-pol2qm74 4202 10 autoradiographies autoradiography NNS cord-015021-pol2qm74 4202 11 of of IN cord-015021-pol2qm74 4202 12 the the DT cord-015021-pol2qm74 4202 13 specific specific JJ cord-015021-pol2qm74 4202 14 cytokine cytokine NN cord-015021-pol2qm74 4202 15 mRNA mrna NN cord-015021-pol2qm74 4202 16 expression expression NN cord-015021-pol2qm74 4202 17 with with IN cord-015021-pol2qm74 4202 18 the the DT cord-015021-pol2qm74 4202 19 protein protein NN cord-015021-pol2qm74 4202 20 release release NN cord-015021-pol2qm74 4202 21 in in IN cord-015021-pol2qm74 4202 22 the the DT cord-015021-pol2qm74 4202 23 supernatants supernatant NNS cord-015021-pol2qm74 4202 24 , , , cord-015021-pol2qm74 4202 25 we -PRON- PRP cord-015021-pol2qm74 4202 26 saw see VBD cord-015021-pol2qm74 4202 27 a a DT cord-015021-pol2qm74 4202 28 good good JJ cord-015021-pol2qm74 4202 29 correlation correlation NN cord-015021-pol2qm74 4202 30 between between IN cord-015021-pol2qm74 4202 31 mRNA mRNA NNP cord-015021-pol2qm74 4202 32 signal signal JJ cord-015021-pol2qm74 4202 33 intensity intensity NN cord-015021-pol2qm74 4202 34 and and CC cord-015021-pol2qm74 4202 35 protein protein NN cord-015021-pol2qm74 4202 36 synthesis synthesis NN cord-015021-pol2qm74 4202 37 for for IN cord-015021-pol2qm74 4202 38 IL-8 IL-8 NNP cord-015021-pol2qm74 4202 39 and and CC cord-015021-pol2qm74 4202 40 11,-2 11,-2 CD cord-015021-pol2qm74 4202 41 , , , cord-015021-pol2qm74 4202 42 suggesting suggest VBG cord-015021-pol2qm74 4202 43 that that IN cord-015021-pol2qm74 4202 44 for for IN cord-015021-pol2qm74 4202 45 these these DT cord-015021-pol2qm74 4202 46 cytokines cytokine NNS cord-015021-pol2qm74 4202 47 the the DT cord-015021-pol2qm74 4202 48 main main JJ cord-015021-pol2qm74 4202 49 regulatory regulatory JJ cord-015021-pol2qm74 4202 50 mechanisms mechanism NNS cord-015021-pol2qm74 4202 51 are be VBP cord-015021-pol2qm74 4202 52 located locate VBN cord-015021-pol2qm74 4202 53 at at IN cord-015021-pol2qm74 4202 54 the the DT cord-015021-pol2qm74 4202 55 pre-/transcriptional pre-/transcriptional JJ cord-015021-pol2qm74 4202 56 level level NN cord-015021-pol2qm74 4202 57 . . . cord-015021-pol2qm74 4203 1 For for IN cord-015021-pol2qm74 4203 2 the the DT cord-015021-pol2qm74 4203 3 other other JJ cord-015021-pol2qm74 4203 4 cytokines cytokine NNS cord-015021-pol2qm74 4203 5 investigated investigate VBD cord-015021-pol2qm74 4203 6 one one CD cord-015021-pol2qm74 4203 7 has have VBZ cord-015021-pol2qm74 4203 8 to to TO cord-015021-pol2qm74 4203 9 suppose suppose VB cord-015021-pol2qm74 4203 10 posttranseriptional posttranseriptional JJ cord-015021-pol2qm74 4203 11 mechanisms mechanism NNS cord-015021-pol2qm74 4203 12 . . . cord-015021-pol2qm74 4204 1 The the DT cord-015021-pol2qm74 4204 2 analysis analysis NN cord-015021-pol2qm74 4204 3 of of IN cord-015021-pol2qm74 4204 4 our -PRON- PRP$ cord-015021-pol2qm74 4204 5 data datum NNS cord-015021-pol2qm74 4204 6 clearly clearly RB cord-015021-pol2qm74 4204 7 indicates indicate VBZ cord-015021-pol2qm74 4204 8 a a DT cord-015021-pol2qm74 4204 9 severe severe JJ cord-015021-pol2qm74 4204 10 impairment impairment NN cord-015021-pol2qm74 4204 11 of of IN cord-015021-pol2qm74 4204 12 forward forward JJ cord-015021-pol2qm74 4204 13 regulatory regulatory JJ cord-015021-pol2qm74 4204 14 immune immune JJ cord-015021-pol2qm74 4204 15 mechanisms mechanism NNS cord-015021-pol2qm74 4204 16 following follow VBG cord-015021-pol2qm74 4204 17 trauma trauma NN cord-015021-pol2qm74 4204 18 . . . cord-015021-pol2qm74 4205 1 Most most RBS cord-015021-pol2qm74 4205 2 likely likely RB cord-015021-pol2qm74 4205 3 the the DT cord-015021-pol2qm74 4205 4 regulatory regulatory JJ cord-015021-pol2qm74 4205 5 mechanisms mechanism NNS cord-015021-pol2qm74 4205 6 , , , cord-015021-pol2qm74 4205 7 that that WDT cord-015021-pol2qm74 4205 8 are be VBP cord-015021-pol2qm74 4205 9 involved involve VBN cord-015021-pol2qm74 4205 10 are be VBP cord-015021-pol2qm74 4205 11 greatly greatly RB cord-015021-pol2qm74 4205 12 different different JJ cord-015021-pol2qm74 4205 13 among among IN cord-015021-pol2qm74 4205 14 the the DT cord-015021-pol2qm74 4205 15 cytokines cytokine NNS cord-015021-pol2qm74 4205 16 investigated investigate VBN cord-015021-pol2qm74 4205 17 . . . cord-015021-pol2qm74 4206 1 It -PRON- PRP cord-015021-pol2qm74 4206 2 may may MD cord-015021-pol2qm74 4206 3 be be VB cord-015021-pol2qm74 4206 4 concluded conclude VBN cord-015021-pol2qm74 4206 5 , , , cord-015021-pol2qm74 4206 6 that that DT cord-015021-pol2qm74 4206 7 depressed depressed JJ cord-015021-pol2qm74 4206 8 CMI CMI NNP cord-015021-pol2qm74 4206 9 responses response NNS cord-015021-pol2qm74 4206 10 post post NN cord-015021-pol2qm74 4206 11 - - NN cord-015021-pol2qm74 4206 12 trauma trauma NN cord-015021-pol2qm74 4206 13 are be VBP cord-015021-pol2qm74 4206 14 partly partly RB cord-015021-pol2qm74 4206 15 due due JJ cord-015021-pol2qm74 4206 16 to to IN cord-015021-pol2qm74 4206 17 an an DT cord-015021-pol2qm74 4206 18 impaired impaired JJ cord-015021-pol2qm74 4206 19 pro pro JJ cord-015021-pol2qm74 4206 20 - - JJ cord-015021-pol2qm74 4206 21 inflammatory inflammatory JJ cord-015021-pol2qm74 4206 22 cytokine cytokine NN cord-015021-pol2qm74 4206 23 production production NN cord-015021-pol2qm74 4206 24 . . . cord-015021-pol2qm74 4207 1 The the DT cord-015021-pol2qm74 4207 2 severity severity NN cord-015021-pol2qm74 4207 3 of of IN cord-015021-pol2qm74 4207 4 the the DT cord-015021-pol2qm74 4207 5 injury injury NN cord-015021-pol2qm74 4207 6 ( ( -LRB- cord-015021-pol2qm74 4207 7 ISS ISS NNP cord-015021-pol2qm74 4207 8 ) ) -RRB- cord-015021-pol2qm74 4207 9 correlated correlate VBD cord-015021-pol2qm74 4207 10 with with IN cord-015021-pol2qm74 4207 11 the the DT cord-015021-pol2qm74 4207 12 development development NN cord-015021-pol2qm74 4207 13 at at IN cord-015021-pol2qm74 4207 14 multiple multiple JJ cord-015021-pol2qm74 4207 15 organ organ NN cord-015021-pol2qm74 4207 16 failure failure NN cord-015021-pol2qm74 4207 17 ( ( -LRB- cord-015021-pol2qm74 4207 18 MOF MOF NNP cord-015021-pol2qm74 4207 19 - - HYPH cord-015021-pol2qm74 4207 20 score score NN cord-015021-pol2qm74 4207 21 ; ; : cord-015021-pol2qm74 4207 22 r=0.612 r=0.612 NNP cord-015021-pol2qm74 4207 23 ) ) -RRB- cord-015021-pol2qm74 4207 24 . . . cord-015021-pol2qm74 4208 1 The the DT cord-015021-pol2qm74 4208 2 levels level NNS cord-015021-pol2qm74 4208 3 of of IN cord-015021-pol2qm74 4208 4 mediators mediator NNS cord-015021-pol2qm74 4208 5 and and CC cord-015021-pol2qm74 4208 6 markers marker NNS cord-015021-pol2qm74 4208 7 of of IN cord-015021-pol2qm74 4208 8 the the DT cord-015021-pol2qm74 4208 9 inflammatory inflammatory JJ cord-015021-pol2qm74 4208 10 response response NN cord-015021-pol2qm74 4208 11 were be VBD cord-015021-pol2qm74 4208 12 generally generally RB cord-015021-pol2qm74 4208 13 higher high JJR cord-015021-pol2qm74 4208 14 in in IN cord-015021-pol2qm74 4208 15 the the DT cord-015021-pol2qm74 4208 16 more more RBR cord-015021-pol2qm74 4208 17 severely severely RB cord-015021-pol2qm74 4208 18 injured injure VBN cord-015021-pol2qm74 4208 19 group group NN cord-015021-pol2qm74 4208 20 ( ( -LRB- cord-015021-pol2qm74 4208 21 ISS>30 ISS>30 NNP cord-015021-pol2qm74 4208 22 , , , cord-015021-pol2qm74 4208 23 n=16 n=16 NNP cord-015021-pol2qm74 4208 24 ) ) -RRB- cord-015021-pol2qm74 4208 25 . . . cord-015021-pol2qm74 4209 1 I1 i1 NN cord-015021-pol2qm74 4209 2 - - HYPH cord-015021-pol2qm74 4209 3 6 6 CD cord-015021-pol2qm74 4209 4 , , , cord-015021-pol2qm74 4209 5 11 11 CD cord-015021-pol2qm74 4209 6 - - SYM cord-015021-pol2qm74 4209 7 8 8 CD cord-015021-pol2qm74 4209 8 , , , cord-015021-pol2qm74 4209 9 G G NNP cord-015021-pol2qm74 4209 10 - - HYPH cord-015021-pol2qm74 4209 11 CSF CSF NNP cord-015021-pol2qm74 4209 12 , , , cord-015021-pol2qm74 4209 13 FPA FPA NNP cord-015021-pol2qm74 4209 14 , , , cord-015021-pol2qm74 4209 15 and and CC cord-015021-pol2qm74 4210 1 C3a C3a NNP cord-015021-pol2qm74 4210 2 -levels -level NNS cord-015021-pol2qm74 4210 3 differed differ VBD cord-015021-pol2qm74 4210 4 significantly significantly RB cord-015021-pol2qm74 4210 5 ( ( -LRB- cord-015021-pol2qm74 4210 6 p<0.005 p<0.005 JJ cord-015021-pol2qm74 4210 7 ) ) -RRB- cord-015021-pol2qm74 4210 8 between between IN cord-015021-pol2qm74 4210 9 the the DT cord-015021-pol2qm74 4210 10 ISS ISS NNP cord-015021-pol2qm74 4210 11 - - HYPH cord-015021-pol2qm74 4210 12 groups group NNS cord-015021-pol2qm74 4210 13 ( ( -LRB- cord-015021-pol2qm74 4210 14 > > XX cord-015021-pol2qm74 4210 15 - - HYPH cord-015021-pol2qm74 4210 16 < < XX cord-015021-pol2qm74 4210 17 ISS ISS NNP cord-015021-pol2qm74 4210 18 30 30 CD cord-015021-pol2qm74 4210 19 ) ) -RRB- cord-015021-pol2qm74 4210 20 at at IN cord-015021-pol2qm74 4210 21 the the DT cord-015021-pol2qm74 4210 22 time time NN cord-015021-pol2qm74 4210 23 of of IN cord-015021-pol2qm74 4210 24 admission admission NN cord-015021-pol2qm74 4210 25 , , , cord-015021-pol2qm74 4210 26 whereas whereas IN cord-015021-pol2qm74 4210 27 on on IN cord-015021-pol2qm74 4210 28 day day NN cord-015021-pol2qm74 4210 29 3 3 CD cord-015021-pol2qm74 4210 30 TNFa TNFa NNS cord-015021-pol2qm74 4210 31 , , , cord-015021-pol2qm74 4210 32 C3a C3a NNP cord-015021-pol2qm74 4210 33 , , , cord-015021-pol2qm74 4210 34 11 11 CD cord-015021-pol2qm74 4210 35 - - SYM cord-015021-pol2qm74 4210 36 6 6 CD cord-015021-pol2qm74 4210 37 , , , cord-015021-pol2qm74 4210 38 and and CC cord-015021-pol2qm74 4210 39 EalPI EalPI NNP cord-015021-pol2qm74 4210 40 showed show VBD cord-015021-pol2qm74 4210 41 significant significant JJ cord-015021-pol2qm74 4210 42 differences difference NNS cord-015021-pol2qm74 4210 43 . . . cord-015021-pol2qm74 4211 1 Beyond beyond IN cord-015021-pol2qm74 4211 2 the the DT cord-015021-pol2qm74 4211 3 first first JJ cord-015021-pol2qm74 4211 4 week week NN cord-015021-pol2qm74 4211 5 , , , cord-015021-pol2qm74 4211 6 major major JJ cord-015021-pol2qm74 4211 7 differences difference NNS cord-015021-pol2qm74 4211 8 were be VBD cord-015021-pol2qm74 4211 9 restricted restrict VBN cord-015021-pol2qm74 4211 10 to to IN cord-015021-pol2qm74 4211 11 PGE PGE NNP cord-015021-pol2qm74 4211 12 2 2 CD cord-015021-pol2qm74 4211 13 and and CC cord-015021-pol2qm74 4211 14 C3a C3a NNP cord-015021-pol2qm74 4211 15 . . . cord-015021-pol2qm74 4212 1 The the DT cord-015021-pol2qm74 4212 2 formation formation NN cord-015021-pol2qm74 4212 3 of of IN cord-015021-pol2qm74 4212 4 two two CD cord-015021-pol2qm74 4212 5 groups group NNS cord-015021-pol2qm74 4212 6 with with IN cord-015021-pol2qm74 4212 7 respect respect NN cord-015021-pol2qm74 4212 8 to to IN cord-015021-pol2qm74 4212 9 later later JJ cord-015021-pol2qm74 4212 10 multiple multiple JJ cord-015021-pol2qm74 4212 11 organ organ NN cord-015021-pol2qm74 4212 12 failure failure NN cord-015021-pol2qm74 4212 13 ( ( -LRB- cord-015021-pol2qm74 4212 14 MOF MOF NNP cord-015021-pol2qm74 4212 15 < < XX cord-015021-pol2qm74 4212 16 3 3 CD cord-015021-pol2qm74 4212 17 ; ; : cord-015021-pol2qm74 4212 18 MOF MOF NNP cord-015021-pol2qm74 4212 19 > > XX cord-015021-pol2qm74 4213 1 2 2 CD cord-015021-pol2qm74 4213 2 n= n= CD cord-015021-pol2qm74 4213 3 14 14 CD cord-015021-pol2qm74 4213 4 ) ) -RRB- cord-015021-pol2qm74 4213 5 yielded yield VBD cord-015021-pol2qm74 4213 6 similar similar JJ cord-015021-pol2qm74 4213 7 results result NNS cord-015021-pol2qm74 4213 8 . . . cord-015021-pol2qm74 4214 1 Leukocyte Leukocyte NNP cord-015021-pol2qm74 4214 2 - - HYPH cord-015021-pol2qm74 4214 3 FACS FACS NNP cord-015021-pol2qm74 4214 4 analysis analysis NN cord-015021-pol2qm74 4214 5 revealed reveal VBD cord-015021-pol2qm74 4214 6 significant significant JJ cord-015021-pol2qm74 4214 7 differences difference NNS cord-015021-pol2qm74 4214 8 mainly mainly RB cord-015021-pol2qm74 4214 9 in in IN cord-015021-pol2qm74 4214 10 the the DT cord-015021-pol2qm74 4214 11 CD14 CD14 NNP cord-015021-pol2qm74 4214 12 ( ( -LRB- cord-015021-pol2qm74 4214 13 monocytes monocyte NNS cord-015021-pol2qm74 4214 14 ) ) -RRB- cord-015021-pol2qm74 4214 15 , , . cord-015021-pol2qm74 4215 1 CD3 CD3 NNP cord-015021-pol2qm74 4215 2 / / SYM cord-015021-pol2qm74 4215 3 CD25 CD25 NNP cord-015021-pol2qm74 4215 4 ( ( -LRB- cord-015021-pol2qm74 4215 5 I1 i1 NN cord-015021-pol2qm74 4215 6 - - HYPH cord-015021-pol2qm74 4215 7 2R 2R NNP cord-015021-pol2qm74 4215 8 + + CC cord-015021-pol2qm74 4215 9 T t NN cord-015021-pol2qm74 4215 10 - - HYPH cord-015021-pol2qm74 4215 11 cells cell NNS cord-015021-pol2qm74 4215 12 ) ) -RRB- cord-015021-pol2qm74 4215 13 , , , cord-015021-pol2qm74 4215 14 and and CC cord-015021-pol2qm74 4215 15 CD29 CD29 NNP cord-015021-pol2qm74 4215 16 / / SYM cord-015021-pol2qm74 4215 17 CD4 CD4 NNP cord-015021-pol2qm74 4215 18 ( ( -LRB- cord-015021-pol2qm74 4215 19 TH TH NNP cord-015021-pol2qm74 4215 20 2calls 2calls CD cord-015021-pol2qm74 4215 21 ) ) -RRB- cord-015021-pol2qm74 4215 22 populations population NNS cord-015021-pol2qm74 4215 23 . . . cord-015021-pol2qm74 4216 1 Summarizing summarize VBG cord-015021-pol2qm74 4216 2 our -PRON- PRP$ cord-015021-pol2qm74 4216 3 findings finding NNS cord-015021-pol2qm74 4216 4 we -PRON- PRP cord-015021-pol2qm74 4216 5 were be VBD cord-015021-pol2qm74 4216 6 able able JJ cord-015021-pol2qm74 4216 7 to to TO cord-015021-pol2qm74 4216 8 detect detect VB cord-015021-pol2qm74 4216 9 some some DT cord-015021-pol2qm74 4216 10 alterations alteration NNS cord-015021-pol2qm74 4216 11 in in IN cord-015021-pol2qm74 4216 12 the the DT cord-015021-pol2qm74 4216 13 surface surface NN cord-015021-pol2qm74 4216 14 antigens antigen NNS cord-015021-pol2qm74 4216 15 of of IN cord-015021-pol2qm74 4216 16 immunocompetent immunocompetent JJ cord-015021-pol2qm74 4216 17 cells cell NNS cord-015021-pol2qm74 4216 18 . . . cord-015021-pol2qm74 4217 1 The the DT cord-015021-pol2qm74 4217 2 inflammato inflammato NNP cord-015021-pol2qm74 4217 3 D D NNP cord-015021-pol2qm74 4217 4 response response NN cord-015021-pol2qm74 4217 5 , , , cord-015021-pol2qm74 4217 6 however however RB cord-015021-pol2qm74 4217 7 , , , cord-015021-pol2qm74 4217 8 seemed seem VBD cord-015021-pol2qm74 4217 9 to to TO cord-015021-pol2qm74 4217 10 be be VB cord-015021-pol2qm74 4217 11 more more RBR cord-015021-pol2qm74 4217 12 pronounced pronounced JJ cord-015021-pol2qm74 4217 13 and and CC cord-015021-pol2qm74 4217 14 correlates correlate VBZ cord-015021-pol2qm74 4217 15 wi~ wi~ PRP cord-015021-pol2qm74 4217 16 the the DT cord-015021-pol2qm74 4217 17 further further JJ cord-015021-pol2qm74 4217 18 clinical clinical JJ cord-015021-pol2qm74 4217 19 course course NN cord-015021-pol2qm74 4217 20 . . . cord-015021-pol2qm74 4218 1 Using use VBG cord-015021-pol2qm74 4218 2 an an DT cord-015021-pol2qm74 4218 3 experimental experimental JJ cord-015021-pol2qm74 4218 4 bum bum NN cord-015021-pol2qm74 4218 5 model model NN cord-015021-pol2qm74 4218 6 in in IN cord-015021-pol2qm74 4218 7 rodents rodent NNS cord-015021-pol2qm74 4218 8 , , , cord-015021-pol2qm74 4218 9 we -PRON- PRP cord-015021-pol2qm74 4218 10 have have VBP cord-015021-pol2qm74 4218 11 demonstrated demonstrate VBN cord-015021-pol2qm74 4218 12 that that IN cord-015021-pol2qm74 4218 13 administration administration NN cord-015021-pol2qm74 4218 14 of of IN cord-015021-pol2qm74 4218 15 a a DT cord-015021-pol2qm74 4218 16 full full JJ cord-015021-pol2qm74 4218 17 thickness thickness NN cord-015021-pol2qm74 4218 18 , , , cord-015021-pol2qm74 4218 19 scald scald NN cord-015021-pol2qm74 4218 20 burn burn VB cord-015021-pol2qm74 4218 21 involving involve VBG cord-015021-pol2qm74 4218 22 20 20 CD cord-015021-pol2qm74 4218 23 % % NN cord-015021-pol2qm74 4218 24 or or CC cord-015021-pol2qm74 4218 25 more more JJR cord-015021-pol2qm74 4218 26 of of IN cord-015021-pol2qm74 4218 27 the the DT cord-015021-pol2qm74 4218 28 total total JJ cord-015021-pol2qm74 4218 29 body body NN cord-015021-pol2qm74 4218 30 surface surface NN cord-015021-pol2qm74 4218 31 area area NN cord-015021-pol2qm74 4218 32 ( ( -LRB- cord-015021-pol2qm74 4218 33 TBSA TBSA NNP cord-015021-pol2qm74 4218 34 ) ) -RRB- cord-015021-pol2qm74 4218 35 elicits elicit VBZ cord-015021-pol2qm74 4218 36 systemic systemic JJ cord-015021-pol2qm74 4218 37 responses response NNS cord-015021-pol2qm74 4218 38 which which WDT cord-015021-pol2qm74 4218 39 are be VBP cord-015021-pol2qm74 4218 40 characterized characterize VBN cord-015021-pol2qm74 4218 41 by by IN cord-015021-pol2qm74 4218 42 numerous numerous JJ cord-015021-pol2qm74 4218 43 alterations alteration NNS cord-015021-pol2qm74 4218 44 in in IN cord-015021-pol2qm74 4218 45 T T NNP cord-015021-pol2qm74 4218 46 - - HYPH cord-015021-pol2qm74 4218 47 ceU ceu JJ cord-015021-pol2qm74 4218 48 function function NN cord-015021-pol2qm74 4218 49 ( ( -LRB- cord-015021-pol2qm74 4218 50 i.e. i.e. FW cord-015021-pol2qm74 4218 51 , , , cord-015021-pol2qm74 4218 52 lymphokine lymphokine NN cord-015021-pol2qm74 4218 53 production production NN cord-015021-pol2qm74 4218 54 and and CC cord-015021-pol2qm74 4218 55 contact contact NN cord-015021-pol2qm74 4218 56 hypersensitivity hypersensitivity NN cord-015021-pol2qm74 4218 57 ( ( -LRB- cord-015021-pol2qm74 4218 58 CH CH NNP cord-015021-pol2qm74 4218 59 ) ) -RRB- cord-015021-pol2qm74 4218 60 responses response NNS cord-015021-pol2qm74 4218 61 ) ) -RRB- cord-015021-pol2qm74 4218 62 plus plus CC cord-015021-pol2qm74 4218 63 an an DT cord-015021-pol2qm74 4218 64 enhanced enhance VBN cord-015021-pol2qm74 4218 65 susceptibility susceptibility NN cord-015021-pol2qm74 4218 66 to to IN cord-015021-pol2qm74 4218 67 bacterial bacterial JJ cord-015021-pol2qm74 4218 68 infection infection NN cord-015021-pol2qm74 4218 69 . . . cord-015021-pol2qm74 4219 1 In in IN cord-015021-pol2qm74 4219 2 the the DT cord-015021-pol2qm74 4219 3 present present JJ cord-015021-pol2qm74 4219 4 study study NN cord-015021-pol2qm74 4219 5 we -PRON- PRP cord-015021-pol2qm74 4219 6 questioned question VBD cord-015021-pol2qm74 4219 7 whether whether IN cord-015021-pol2qm74 4219 8 the the DT cord-015021-pol2qm74 4219 9 apparent apparent JJ cord-015021-pol2qm74 4219 10 systemic systemic JJ cord-015021-pol2qm74 4219 11 effects effect NNS cord-015021-pol2qm74 4219 12 mediated mediate VBN cord-015021-pol2qm74 4219 13 by by IN cord-015021-pol2qm74 4219 14 large large JJ cord-015021-pol2qm74 4219 15 burns burn NNS cord-015021-pol2qm74 4219 16 would would MD cord-015021-pol2qm74 4219 17 be be VB cord-015021-pol2qm74 4219 18 elicited elicit VBN cord-015021-pol2qm74 4219 19 as as IN cord-015021-pol2qm74 4219 20 site site NN cord-015021-pol2qm74 4219 21 - - HYPH cord-015021-pol2qm74 4219 22 specific specific JJ cord-015021-pol2qm74 4219 23 alterations alteration NNS cord-015021-pol2qm74 4219 24 in in IN cord-015021-pol2qm74 4219 25 immune immune JJ cord-015021-pol2qm74 4219 26 function function NN cord-015021-pol2qm74 4219 27 following follow VBG cord-015021-pol2qm74 4219 28 administration administration NN cord-015021-pol2qm74 4219 29 of of IN cord-015021-pol2qm74 4219 30 small small JJ cord-015021-pol2qm74 4219 31 area area NN cord-015021-pol2qm74 4219 32 burn burn VBP cord-015021-pol2qm74 4219 33 trauma trauma NN cord-015021-pol2qm74 4219 34 ( ( -LRB- cord-015021-pol2qm74 4219 35 5 5 CD cord-015021-pol2qm74 4219 36 % % NN cord-015021-pol2qm74 4219 37 TBSA TBSA NNP cord-015021-pol2qm74 4219 38 ) ) -RRB- cord-015021-pol2qm74 4219 39 . . . cord-015021-pol2qm74 4220 1 Following follow VBG cord-015021-pol2qm74 4220 2 a a DT cord-015021-pol2qm74 4220 3 20 20 CD cord-015021-pol2qm74 4220 4 % % NN cord-015021-pol2qm74 4220 5 TBSA TBSA NNP cord-015021-pol2qm74 4220 6 burn burn NN cord-015021-pol2qm74 4220 7 , , , cord-015021-pol2qm74 4220 8 CH CH NNP cord-015021-pol2qm74 4220 9 responses response NNS cord-015021-pol2qm74 4220 10 to to TO cord-015021-pol2qm74 4220 11 contact contact VB cord-015021-pol2qm74 4220 12 sensitizing sensitize VBG cord-015021-pol2qm74 4220 13 antigens antigen NNS cord-015021-pol2qm74 4220 14 were be VBD cord-015021-pol2qm74 4220 15 found find VBN cord-015021-pol2qm74 4220 16 to to TO cord-015021-pol2qm74 4220 17 be be VB cord-015021-pol2qm74 4220 18 altered alter VBN cord-015021-pol2qm74 4220 19 . . . cord-015021-pol2qm74 4221 1 The the DT cord-015021-pol2qm74 4221 2 depression depression NN cord-015021-pol2qm74 4221 3 in in IN cord-015021-pol2qm74 4221 4 CH CH NNP cord-015021-pol2qm74 4221 5 responses response NNS cord-015021-pol2qm74 4221 6 could could MD cord-015021-pol2qm74 4221 7 be be VB cord-015021-pol2qm74 4221 8 induced induce VBN cord-015021-pol2qm74 4221 9 independent independent JJ cord-015021-pol2qm74 4221 10 of of IN cord-015021-pol2qm74 4221 11 the the DT cord-015021-pol2qm74 4221 12 site site NN cord-015021-pol2qm74 4221 13 used use VBN cord-015021-pol2qm74 4221 14 for for IN cord-015021-pol2qm74 4221 15 topical topical JJ cord-015021-pol2qm74 4221 16 skin skin NN cord-015021-pol2qm74 4221 17 sensitization sensitization NN cord-015021-pol2qm74 4221 18 . . . cord-015021-pol2qm74 4222 1 Following follow VBG cord-015021-pol2qm74 4222 2 a a DT cord-015021-pol2qm74 4222 3 5 5 CD cord-015021-pol2qm74 4222 4 % % NN cord-015021-pol2qm74 4222 5 TBSA TBSA NNP cord-015021-pol2qm74 4222 6 thermal thermal JJ cord-015021-pol2qm74 4222 7 injury injury NN cord-015021-pol2qm74 4222 8 , , , cord-015021-pol2qm74 4222 9 development development NN cord-015021-pol2qm74 4222 10 of of IN cord-015021-pol2qm74 4222 11 CH CH NNP cord-015021-pol2qm74 4222 12 responses response NNS cord-015021-pol2qm74 4222 13 were be VBD cord-015021-pol2qm74 4222 14 affected affect VBN cord-015021-pol2qm74 4222 15 in in IN cord-015021-pol2qm74 4222 16 a a DT cord-015021-pol2qm74 4222 17 site site NN cord-015021-pol2qm74 4222 18 - - HYPH cord-015021-pol2qm74 4222 19 specific specific JJ cord-015021-pol2qm74 4222 20 manner manner NN cord-015021-pol2qm74 4222 21 . . . cord-015021-pol2qm74 4223 1 Immunization immunization NN cord-015021-pol2qm74 4223 2 of of IN cord-015021-pol2qm74 4223 3 5 5 CD cord-015021-pol2qm74 4223 4 % % NN cord-015021-pol2qm74 4223 5 TBSA TBSA NNP cord-015021-pol2qm74 4223 6 thermally thermally RB cord-015021-pol2qm74 4223 7 injured injure VBD cord-015021-pol2qm74 4223 8 mice mouse NNS cord-015021-pol2qm74 4223 9 in in IN cord-015021-pol2qm74 4223 10 a a DT cord-015021-pol2qm74 4223 11 site site NN cord-015021-pol2qm74 4223 12 near near IN cord-015021-pol2qm74 4223 13 the the DT cord-015021-pol2qm74 4223 14 position position NN cord-015021-pol2qm74 4223 15 of of IN cord-015021-pol2qm74 4223 16 the the DT cord-015021-pol2qm74 4223 17 burn burn NN cord-015021-pol2qm74 4223 18 resulted result VBD cord-015021-pol2qm74 4223 19 in in IN cord-015021-pol2qm74 4223 20 depressed depressed JJ cord-015021-pol2qm74 4223 21 responsiveness responsiveness NN cord-015021-pol2qm74 4223 22 , , , cord-015021-pol2qm74 4223 23 whereas whereas IN cord-015021-pol2qm74 4223 24 immunization immunization NN cord-015021-pol2qm74 4223 25 through through IN cord-015021-pol2qm74 4223 26 a a DT cord-015021-pol2qm74 4223 27 contralateral contralateral JJ cord-015021-pol2qm74 4223 28 site site NN cord-015021-pol2qm74 4223 29 resulted result VBD cord-015021-pol2qm74 4223 30 in in IN cord-015021-pol2qm74 4223 31 responses response NNS cord-015021-pol2qm74 4223 32 that that WDT cord-015021-pol2qm74 4223 33 displayed display VBD cord-015021-pol2qm74 4223 34 both both CC cord-015021-pol2qm74 4223 35 the the DT cord-015021-pol2qm74 4223 36 intensity intensity NN cord-015021-pol2qm74 4223 37 and and CC cord-015021-pol2qm74 4223 38 kinetics kinetic NNS cord-015021-pol2qm74 4223 39 of of IN cord-015021-pol2qm74 4223 40 a a DT cord-015021-pol2qm74 4223 41 CH CH NNP cord-015021-pol2qm74 4223 42 response response NN cord-015021-pol2qm74 4223 43 equivalent equivalent JJ cord-015021-pol2qm74 4223 44 to to IN cord-015021-pol2qm74 4223 45 sham sham NN cord-015021-pol2qm74 4223 46 - - HYPH cord-015021-pol2qm74 4223 47 bumed bum VBN cord-015021-pol2qm74 4223 48 mice mouse NNS cord-015021-pol2qm74 4223 49 . . . cord-015021-pol2qm74 4224 1 Similar similar JJ cord-015021-pol2qm74 4224 2 systemic systemic JJ cord-015021-pol2qm74 4224 3 and and CC cord-015021-pol2qm74 4224 4 site site NN cord-015021-pol2qm74 4224 5 - - HYPH cord-015021-pol2qm74 4224 6 limited limit VBN cord-015021-pol2qm74 4224 7 changes change NNS cord-015021-pol2qm74 4224 8 in in IN cord-015021-pol2qm74 4224 9 lymphokine lymphokine NN cord-015021-pol2qm74 4224 10 production production NN cord-015021-pol2qm74 4224 11 were be VBD cord-015021-pol2qm74 4224 12 observed observe VBN cord-015021-pol2qm74 4224 13 with with IN cord-015021-pol2qm74 4224 14 20 20 CD cord-015021-pol2qm74 4224 15 % % NN cord-015021-pol2qm74 4224 16 and and CC cord-015021-pol2qm74 4224 17 5 5 CD cord-015021-pol2qm74 4224 18 % % NN cord-015021-pol2qm74 4224 19 TBSA TBSA NNP cord-015021-pol2qm74 4224 20 thermal thermal JJ cord-015021-pol2qm74 4224 21 injuries injury NNS cord-015021-pol2qm74 4224 22 , , , cord-015021-pol2qm74 4224 23 respectively respectively RB cord-015021-pol2qm74 4224 24 . . . cord-015021-pol2qm74 4225 1 A a DT cord-015021-pol2qm74 4225 2 20 20 CD cord-015021-pol2qm74 4225 3 % % NN cord-015021-pol2qm74 4225 4 TBSA TBSA NNP cord-015021-pol2qm74 4225 5 injury injury NN cord-015021-pol2qm74 4225 6 affected affect VBD cord-015021-pol2qm74 4225 7 the the DT cord-015021-pol2qm74 4225 8 lymphokine lymphokine NN cord-015021-pol2qm74 4225 9 producing produce VBG cord-015021-pol2qm74 4225 10 potential potential NN cord-015021-pol2qm74 4225 11 of of IN cord-015021-pol2qm74 4225 12 all all DT cord-015021-pol2qm74 4225 13 cells cell NNS cord-015021-pol2qm74 4225 14 regardless regardless RB cord-015021-pol2qm74 4225 15 of of IN cord-015021-pol2qm74 4225 16 which which WDT cord-015021-pol2qm74 4225 17 lymphoid lymphoid JJ cord-015021-pol2qm74 4225 18 tissue tissue VBP cord-015021-pol2qm74 4225 19 the the DT cord-015021-pol2qm74 4225 20 cells cell NNS cord-015021-pol2qm74 4225 21 were be VBD cord-015021-pol2qm74 4225 22 isolated isolate VBN cord-015021-pol2qm74 4225 23 from from IN cord-015021-pol2qm74 4225 24 . . . cord-015021-pol2qm74 4226 1 The the DT cord-015021-pol2qm74 4226 2 effect effect NN cord-015021-pol2qm74 4226 3 of of IN cord-015021-pol2qm74 4226 4 a a DT cord-015021-pol2qm74 4226 5 5 5 CD cord-015021-pol2qm74 4226 6 % % NN cord-015021-pol2qm74 4226 7 TBSA TBSA NNP cord-015021-pol2qm74 4226 8 burn burn NN cord-015021-pol2qm74 4226 9 was be VBD cord-015021-pol2qm74 4226 10 significant significant JJ cord-015021-pol2qm74 4226 11 but but CC cord-015021-pol2qm74 4226 12 site site NN cord-015021-pol2qm74 4226 13 - - HYPH cord-015021-pol2qm74 4226 14 specific specific JJ cord-015021-pol2qm74 4226 15 . . . cord-015021-pol2qm74 4227 1 Thus thus RB cord-015021-pol2qm74 4227 2 , , , cord-015021-pol2qm74 4227 3 ceils ceil NNS cord-015021-pol2qm74 4227 4 from from IN cord-015021-pol2qm74 4227 5 lymph lymph NN cord-015021-pol2qm74 4227 6 nodes node NNS cord-015021-pol2qm74 4227 7 receiving receive VBG cord-015021-pol2qm74 4227 8 drainage drainage NN cord-015021-pol2qm74 4227 9 from from IN cord-015021-pol2qm74 4227 10 thermally thermally RB cord-015021-pol2qm74 4227 11 injured injure VBN cord-015021-pol2qm74 4227 12 tissue tissue NN cord-015021-pol2qm74 4227 13 were be VBD cord-015021-pol2qm74 4227 14 specifically specifically RB cord-015021-pol2qm74 4227 15 affected affect VBN cord-015021-pol2qm74 4227 16 , , , cord-015021-pol2qm74 4227 17 whereas whereas IN cord-015021-pol2qm74 4227 18 lymphokine lymphokine NN cord-015021-pol2qm74 4227 19 production production NN cord-015021-pol2qm74 4227 20 by by IN cord-015021-pol2qm74 4227 21 cells cell NNS cord-015021-pol2qm74 4227 22 from from IN cord-015021-pol2qm74 4227 23 lymphoid lymphoid JJ cord-015021-pol2qm74 4227 24 organs organ NNS cord-015021-pol2qm74 4227 25 receiving receive VBG cord-015021-pol2qm74 4227 26 drainage drainage NN cord-015021-pol2qm74 4227 27 from from IN cord-015021-pol2qm74 4227 28 unaffected unaffected JJ cord-015021-pol2qm74 4227 29 skin skin NN cord-015021-pol2qm74 4227 30 was be VBD cord-015021-pol2qm74 4227 31 normal normal JJ cord-015021-pol2qm74 4227 32 . . . cord-015021-pol2qm74 4228 1 It -PRON- PRP cord-015021-pol2qm74 4228 2 was be VBD cord-015021-pol2qm74 4228 3 concluded conclude VBN cord-015021-pol2qm74 4228 4 that that IN cord-015021-pol2qm74 4228 5 modulation modulation NN cord-015021-pol2qm74 4228 6 of of IN cord-015021-pol2qm74 4228 7 lymphokine lymphokine NN cord-015021-pol2qm74 4228 8 production production NN cord-015021-pol2qm74 4228 9 and and CC cord-015021-pol2qm74 4228 10 cellular cellular JJ cord-015021-pol2qm74 4228 11 immune immune JJ cord-015021-pol2qm74 4228 12 responses response NNS cord-015021-pol2qm74 4228 13 may may MD cord-015021-pol2qm74 4228 14 be be VB cord-015021-pol2qm74 4228 15 a a DT cord-015021-pol2qm74 4228 16 normal normal JJ cord-015021-pol2qm74 4228 17 consequence consequence NN cord-015021-pol2qm74 4228 18 of of IN cord-015021-pol2qm74 4228 19 burntrauma burntrauma NN cord-015021-pol2qm74 4228 20 regardless regardless RB cord-015021-pol2qm74 4228 21 of of IN cord-015021-pol2qm74 4228 22 the the DT cord-015021-pol2qm74 4228 23 size size NN cord-015021-pol2qm74 4228 24 of of IN cord-015021-pol2qm74 4228 25 the the DT cord-015021-pol2qm74 4228 26 burn burn NN cord-015021-pol2qm74 4228 27 . . . cord-015021-pol2qm74 4229 1 Changes change NNS cord-015021-pol2qm74 4229 2 in in IN cord-015021-pol2qm74 4229 3 immune immune JJ cord-015021-pol2qm74 4229 4 competence competence NN cord-015021-pol2qm74 4229 5 can can MD cord-015021-pol2qm74 4229 6 be be VB cord-015021-pol2qm74 4229 7 mediated mediate VBN cord-015021-pol2qm74 4229 8 either either CC cord-015021-pol2qm74 4229 9 regionally regionally RB cord-015021-pol2qm74 4229 10 or or CC cord-015021-pol2qm74 4229 11 systemically systemically RB cord-015021-pol2qm74 4229 12 in in IN cord-015021-pol2qm74 4229 13 direct direct JJ cord-015021-pol2qm74 4229 14 proportion proportion NN cord-015021-pol2qm74 4229 15 to to IN cord-015021-pol2qm74 4229 16 the the DT cord-015021-pol2qm74 4229 17 area area NN cord-015021-pol2qm74 4229 18 of of IN cord-015021-pol2qm74 4229 19 skin skin NN cord-015021-pol2qm74 4229 20 exposed expose VBN cord-015021-pol2qm74 4229 21 to to IN cord-015021-pol2qm74 4229 22 the the DT cord-015021-pol2qm74 4229 23 burn burn NN cord-015021-pol2qm74 4229 24 injury injury NN cord-015021-pol2qm74 4229 25 . . . cord-015021-pol2qm74 4230 1 This this DT cord-015021-pol2qm74 4230 2 work work NN cord-015021-pol2qm74 4230 3 is be VBZ cord-015021-pol2qm74 4230 4 supported support VBN cord-015021-pol2qm74 4230 5 by by IN cord-015021-pol2qm74 4230 6 PHS PHS NNP cord-015021-pol2qm74 4230 7 grant grant VBP cord-015021-pol2qm74 4230 8 GM46899 GM46899 NNP cord-015021-pol2qm74 4230 9 and and CC cord-015021-pol2qm74 4230 10 the the DT cord-015021-pol2qm74 4230 11 Office Office NNP cord-015021-pol2qm74 4230 12 of of IN cord-015021-pol2qm74 4230 13 Navy Navy NNP cord-015021-pol2qm74 4230 14 Research Research NNP cord-015021-pol2qm74 4230 15 N00014 N00014 NNP cord-015021-pol2qm74 4230 16 - - HYPH cord-015021-pol2qm74 4230 17 92-J-1612 92-J-1612 NNP cord-015021-pol2qm74 4230 18 . . . cord-015021-pol2qm74 4231 1 Division division NN cord-015021-pol2qm74 4231 2 of of IN cord-015021-pol2qm74 4231 3 Cell Cell NNP cord-015021-pol2qm74 4231 4 Biology Biology NNP cord-015021-pol2qm74 4231 5 and and CC cord-015021-pol2qm74 4231 6 Immunology Immunology NNP cord-015021-pol2qm74 4231 7 , , , cord-015021-pol2qm74 4231 8 Department Department NNP cord-015021-pol2qm74 4231 9 of of IN cord-015021-pol2qm74 4231 10 Pathology Pathology NNP cord-015021-pol2qm74 4231 11 , , , cord-015021-pol2qm74 4231 12 University University NNP cord-015021-pol2qm74 4231 13 of of IN cord-015021-pol2qm74 4231 14 Utah Utah NNP cord-015021-pol2qm74 4231 15 School School NNP cord-015021-pol2qm74 4231 16 of of IN cord-015021-pol2qm74 4231 17 Medicine Medicine NNP cord-015021-pol2qm74 4231 18 , , , cord-015021-pol2qm74 4231 19 Salt Salt NNP cord-015021-pol2qm74 4231 20 Lake Lake NNP cord-015021-pol2qm74 4231 21 City City NNP cord-015021-pol2qm74 4231 22 , , , cord-015021-pol2qm74 4231 23 UT UT NNP cord-015021-pol2qm74 4231 24 84132 84132 CD cord-015021-pol2qm74 4231 25 . . . cord-015021-pol2qm74 4232 1 Post post JJ cord-015021-pol2qm74 4232 2 spleneetomy spleneetomy NN cord-015021-pol2qm74 4232 3 septic septic JJ cord-015021-pol2qm74 4232 4 sequelae sequela NNS cord-015021-pol2qm74 4232 5 may may MD cord-015021-pol2qm74 4232 6 Be be VB cord-015021-pol2qm74 4232 7 fatal fatal JJ cord-015021-pol2qm74 4232 8 , , , cord-015021-pol2qm74 4232 9 but but CC cord-015021-pol2qm74 4232 10 the the DT cord-015021-pol2qm74 4232 11 mechanisms mechanism NNS cord-015021-pol2qm74 4232 12 remain remain VBP cord-015021-pol2qm74 4232 13 unclear unclear JJ cord-015021-pol2qm74 4232 14 . . . cord-015021-pol2qm74 4233 1 The the DT cord-015021-pol2qm74 4233 2 objectives objective NNS cord-015021-pol2qm74 4233 3 ef ef NNP cord-015021-pol2qm74 4233 4 this this DT cord-015021-pol2qm74 4233 5 study study NN cord-015021-pol2qm74 4233 6 were be VBD cord-015021-pol2qm74 4233 7 to to TO cord-015021-pol2qm74 4233 8 assess assess VB cord-015021-pol2qm74 4233 9 the the DT cord-015021-pol2qm74 4233 10 mortality mortality NN cord-015021-pol2qm74 4233 11 from from IN cord-015021-pol2qm74 4233 12 concomitant concomitant JJ cord-015021-pol2qm74 4233 13 splen-'etomy splen-'etomy NN cord-015021-pol2qm74 4233 14 and and CC cord-015021-pol2qm74 4233 15 ] ] -RRB- cord-015021-pol2qm74 4234 1 ~eritoneal ~eritoneal JJ cord-015021-pol2qm74 4234 2 bacterial bacterial JJ cord-015021-pol2qm74 4234 3 challenge challenge NN cord-015021-pol2qm74 4234 4 and and CC cord-015021-pol2qm74 4234 5 to to TO cord-015021-pol2qm74 4234 6 elucidate elucidate VB cord-015021-pol2qm74 4234 7 the the DT cord-015021-pol2qm74 4234 8 local local JJ cord-015021-pol2qm74 4234 9 cetkdar cetkdar NN cord-015021-pol2qm74 4234 10 responses response NNS cord-015021-pol2qm74 4234 11 . . . cord-015021-pol2qm74 4235 1 50 50 CD cord-015021-pol2qm74 4235 2 CD-1 CD-1 NNP cord-015021-pol2qm74 4235 3 mice mouse NNS cord-015021-pol2qm74 4235 4 were be VBD cord-015021-pol2qm74 4235 5 randomised randomised JJ cord-015021-pol2qm74 4235 6 to to TO cord-015021-pol2qm74 4235 7 receive receive VB cord-015021-pol2qm74 4235 8 laparotomy laparotomy NN cord-015021-pol2qm74 4235 9 and and CC cord-015021-pol2qm74 4235 10 sham sham NN cord-015021-pol2qm74 4235 11 splenectomy splenectomy NN cord-015021-pol2qm74 4235 12 ( ( -LRB- cord-015021-pol2qm74 4235 13 L L NNP cord-015021-pol2qm74 4235 14 ) ) -RRB- cord-015021-pol2qm74 4235 15 or or CC cord-015021-pol2qm74 4235 16 splenectomy splenectomy NN cord-015021-pol2qm74 4235 17 ( ( -LRB- cord-015021-pol2qm74 4235 18 S s NN cord-015021-pol2qm74 4235 19 ) ) -RRB- cord-015021-pol2qm74 4235 20 with with IN cord-015021-pol2qm74 4235 21 simultaneous simultaneous JJ cord-015021-pol2qm74 4235 22 ca'-cal ca'-cal JJ cord-015021-pol2qm74 4235 23 ligation ligation NN cord-015021-pol2qm74 4235 24 and and CC cord-015021-pol2qm74 4235 25 " " '' cord-015021-pol2qm74 4235 26 ) ) -RRB- cord-015021-pol2qm74 4235 27 : : : cord-015021-pol2qm74 4235 28 mcture mcture NNP cord-015021-pol2qm74 4235 29 and and CC cord-015021-pol2qm74 4235 30 the the DT cord-015021-pol2qm74 4235 31 survival survival NN cord-015021-pol2qm74 4235 32 patterns pattern NNS cord-015021-pol2qm74 4235 33 assessed assess VBN cord-015021-pol2qm74 4235 34 . . . cord-015021-pol2qm74 4236 1 Subsequently subsequently RB cord-015021-pol2qm74 4236 2 , , , cord-015021-pol2qm74 4236 3 150 150 CD cord-015021-pol2qm74 4236 4 CD-1 CD-1 NNP cord-015021-pol2qm74 4236 5 mice mouse NNS cord-015021-pol2qm74 4236 6 were be VBD cord-015021-pol2qm74 4236 7 randomised randomised JJ cord-015021-pol2qm74 4236 8 into into IN cord-015021-pol2qm74 4236 9 control control NN cord-015021-pol2qm74 4236 10 ( ( -LRB- cord-015021-pol2qm74 4236 11 C C NNP cord-015021-pol2qm74 4236 12 ) ) -RRB- cord-015021-pol2qm74 4236 13 , , , cord-015021-pol2qm74 4236 14 L L NNP cord-015021-pol2qm74 4236 15 or or CC cord-015021-pol2qm74 4236 16 S S NNP cord-015021-pol2qm74 4236 17 groups group NNS cord-015021-pol2qm74 4236 18 and and CC cord-015021-pol2qm74 4236 19 peritoneal peritoneal JJ cord-015021-pol2qm74 4236 20 cells cell NNS cord-015021-pol2qm74 4236 21 studied study VBD cord-015021-pol2qm74 4236 22 at at IN cord-015021-pol2qm74 4236 23 24 24 CD cord-015021-pol2qm74 4236 24 hours hour NNS cord-015021-pol2qm74 4236 25 for for IN cord-015021-pol2qm74 4236 26 bacterial bacterial JJ cord-015021-pol2qm74 4236 27 phagocytosis phagocytosis NN cord-015021-pol2qm74 4236 28 and and CC cord-015021-pol2qm74 4236 29 killi:~g killi:~g NN cord-015021-pol2qm74 4236 30 , , , cord-015021-pol2qm74 4236 31 superoxide superoxide NN cord-015021-pol2qm74 4236 32 ( ( -LRB- cord-015021-pol2qm74 4236 33 02- 02- NNP cord-015021-pol2qm74 4236 34 ) ) -RRB- cord-015021-pol2qm74 4236 35 and and CC cord-015021-pol2qm74 4236 36 tumour tumour NN cord-015021-pol2qm74 4236 37 necrosis necrosis NN cord-015021-pol2qm74 4236 38 factor factor NN cord-015021-pol2qm74 4236 39 ( ( -LRB- cord-015021-pol2qm74 4236 40 TNF TNF NNP cord-015021-pol2qm74 4236 41 ) ) -RRB- cord-015021-pol2qm74 4236 42 production production NN cord-015021-pol2qm74 4236 43 and and CC cord-015021-pol2qm74 4236 44 macrophage macrophage NN cord-015021-pol2qm74 4236 45 activation activation NN cord-015021-pol2qm74 4236 46 vsing vse VBG cord-015021-pol2qm74 4236 47 MAC MAC NNP cord-015021-pol2qm74 4236 48 - - HYPH cord-015021-pol2qm74 4236 49 I(CD-11b I(CD-11b NNPS cord-015021-pol2qm74 4236 50 ) ) -RRB- cord-015021-pol2qm74 4236 51 receptor receptor NN cord-015021-pol2qm74 4236 52 in~.ensity in~.ensity NN cord-015021-pol2qm74 4236 53 expressed express VBD cord-015021-pol2qm74 4236 54 es es NNP cord-015021-pol2qm74 4236 55 mean mean NNP cord-015021-pol2qm74 4236 56 channel channel NNP cord-015021-pol2qm74 4236 57 of of IN cord-015021-pol2qm74 4236 58 fluorescence fluorescence NN cord-015021-pol2qm74 4236 59 ( ( -LRB- cord-015021-pol2qm74 4236 60 MCF MCF NNP cord-015021-pol2qm74 4236 61 ) ) -RRB- cord-015021-pol2qm74 4236 62 . . . cord-015021-pol2qm74 4237 1 These these DT cord-015021-pol2qm74 4237 2 resides reside NNS cord-015021-pol2qm74 4237 3 indicate indicate VBP cord-015021-pol2qm74 4237 4 that that IN cord-015021-pol2qm74 4237 5 SF!enectomy SF!enectomy NNP cord-015021-pol2qm74 4237 6 predisposes predispose VBZ cord-015021-pol2qm74 4237 7 to to TO cord-015021-pol2qm74 4237 8 nrortal nrortal VB cord-015021-pol2qm74 4237 9 ~ ~ NFP cord-015021-pol2qm74 4237 10 ty ty UH cord-015021-pol2qm74 4237 11 from from IN cord-015021-pol2qm74 4237 12 bacterial bacterial JJ cord-015021-pol2qm74 4237 13 sepsis sepsis NN cord-015021-pol2qm74 4237 14 ia ia NNP cord-015021-pol2qm74 4237 15 the the DT cord-015021-pol2qm74 4237 16 early early JJ cord-015021-pol2qm74 4237 17 pos~ pos~ CD cord-015021-pol2qm74 4237 18 operative operative JJ cord-015021-pol2qm74 4237 19 period period NN cord-015021-pol2qm74 4237 20 compared compare VBN cord-015021-pol2qm74 4237 21 to to IN cord-015021-pol2qm74 4237 22 sham sham NN cord-015021-pol2qm74 4237 23 operated operate VBN cord-015021-pol2qm74 4237 24 animals animal NNS cord-015021-pol2qm74 4237 25 . . . cord-015021-pol2qm74 4238 1 Failure failure NN cord-015021-pol2qm74 4239 1 ~f ~f NNP cord-015021-pol2qm74 4239 2 P'.acrophages p'.acrophage VBZ cord-015021-pol2qm74 4239 3 to to TO cord-015021-pol2qm74 4239 4 kill kill VB cord-015021-pol2qm74 4239 5 bacteria bacteria NNS cord-015021-pol2qm74 4239 6 in in IN cord-015021-pol2qm74 4239 7 the the DT cord-015021-pol2qm74 4239 8 splenectomv splenectomv NNP cord-015021-pol2qm74 4239 9 group group NNP cord-015021-pol2qm74 4239 10 ' ' '' cord-015021-pol2qm74 4240 1 ~:cured ~:cure VBN cord-015021-pol2qm74 4240 2 in in IN cord-015021-pol2qm74 4240 3 t?~e t?~e JJ cord-015021-pol2qm74 4240 4 absence absence NN cord-015021-pol2qm74 4240 5 of of IN cord-015021-pol2qm74 4240 6 impairment impairment NN cord-015021-pol2qm74 4240 7 of of IN cord-015021-pol2qm74 4240 8 oxygen oxygen NN cord-015021-pol2qm74 4240 9 freeradical freeradical JJ cord-015021-pol2qm74 4240 10 or or CC cord-015021-pol2qm74 4240 11 TNF TNF NNP cord-015021-pol2qm74 4240 12 pred:~ctien pred:~ctien NNP cord-015021-pol2qm74 4240 13 . . . cord-015021-pol2qm74 4241 1 The the DT cord-015021-pol2qm74 4241 2 macrovh~ macrovh~ NNP cord-015021-pol2qm74 4242 1 ge ge NNP cord-015021-pol2qm74 4242 2 ac!ivotion ac!ivotion NNP cord-015021-pol2qm74 4242 3 marker marker NN cord-015021-pol2qm74 4242 4 MAC-1 MAC-1 NNP cord-015021-pol2qm74 4242 5 was be VBD cord-015021-pol2qm74 4242 6 significantly significantly RB cord-015021-pol2qm74 4242 7 reduced reduce VBN cord-015021-pol2qm74 4242 8 in in IN cord-015021-pol2qm74 4242 9 both both DT cord-015021-pol2qm74 4242 10 L L NNP cord-015021-pol2qm74 4242 11 and and CC cord-015021-pol2qm74 4242 12 S S NNP cord-015021-pol2qm74 4242 13 groups group NNS cord-015021-pol2qm74 4242 14 and and CC cord-015021-pol2qm74 4242 15 impaired impaired JJ cord-015021-pol2qm74 4242 16 phagocytosis phagocytosis NN cord-015021-pol2qm74 4242 17 of of IN cord-015021-pol2qm74 4242 18 bacteria bacteria NNS cord-015021-pol2qm74 4242 19 oceured oceure VBN cord-015021-pol2qm74 4242 20 in in IN cord-015021-pol2qm74 4242 21 both both DT cord-015021-pol2qm74 4242 22 operative operative JJ cord-015021-pol2qm74 4242 23 groups group NNS cord-015021-pol2qm74 4242 24 compared compare VBN cord-015021-pol2qm74 4242 25 to to IN cord-015021-pol2qm74 4242 26 controls control NNS cord-015021-pol2qm74 4242 27 . . . cord-015021-pol2qm74 4243 1 Laparotomy laparotomy NN cord-015021-pol2qm74 4243 2 a!one a!one NN cord-015021-pol2qm74 4243 3 reduces reduce VBZ cord-015021-pol2qm74 4243 4 macrophage macrophage NN cord-015021-pol2qm74 4243 5 activity activity NN cord-015021-pol2qm74 4243 6 in in IN cord-015021-pol2qm74 4243 7 terms term NNS cord-015021-pol2qm74 4243 8 of of IN cord-015021-pol2qm74 4243 9 surface surface NN cord-015021-pol2qm74 4243 10 re re NNP cord-015021-pol2qm74 4243 11 : : : cord-015021-pol2qm74 4243 12 eptor eptor NNP cord-015021-pol2qm74 4243 13 MAC-1 MAC-1 NNP cord-015021-pol2qm74 4243 14 expression expression NN cord-015021-pol2qm74 4243 15 and and CC cord-015021-pol2qm74 4243 16 ! ! . cord-015021-pol2qm74 4244 1 ingestive ingestive JJ cord-015021-pol2qm74 4244 2 capacity capacity NN cord-015021-pol2qm74 4244 3 . . . cord-015021-pol2qm74 4245 1 Splenectomy Splenectomy NNP cord-015021-pol2qm74 4245 2 however however RB cord-015021-pol2qm74 4245 3 s s VBZ cord-015021-pol2qm74 4245 4 ~ ~ CD cord-015021-pol2qm74 4245 5 gnificantiy gnificantiy NNP cord-015021-pol2qm74 4246 1 ~mpairs ~mpairs NNP cord-015021-pol2qm74 4246 2 r r NN cord-015021-pol2qm74 4246 3 - - HYPH cord-015021-pol2qm74 4246 4 acrophage acrophage NN cord-015021-pol2qm74 4246 5 - - HYPH cord-015021-pol2qm74 4246 6 wediated wediate VBN cord-015021-pol2qm74 4246 7 l~,acterial l~,acterial CD cord-015021-pol2qm74 4246 8 killing killing NN cord-015021-pol2qm74 4246 9 and and CC cord-015021-pol2qm74 4246 10 this this DT cord-015021-pol2qm74 4246 11 qefect qefect NN cord-015021-pol2qm74 4247 1 rTtav rTtav NNP cord-015021-pol2qm74 4247 2 co co NN cord-015021-pol2qm74 4247 3 ~ ~ CD cord-015021-pol2qm74 4247 4 tribut~ tribut~ NNP cord-015021-pol2qm74 4247 5 sig~ sig~ CD cord-015021-pol2qm74 4248 1 ifJcav'ly ifjcav'ly XX cord-015021-pol2qm74 4249 1 to to IN cord-015021-pol2qm74 4249 2 th-~ th-~ NNP cord-015021-pol2qm74 4249 3 dissemination dissemination NN cord-015021-pol2qm74 4249 4 of of IN cord-015021-pol2qm74 4249 5 local local JJ cord-015021-pol2qm74 4249 6 infection infection NN cord-015021-pol2qm74 4249 7 and and CC cord-015021-pol2qm74 4249 8 to to IN cord-015021-pol2qm74 4249 9 n':ortalit n':ortalit CD cord-015021-pol2qm74 4249 10 ) ) -RRB- cord-015021-pol2qm74 4249 11 . . . cord-015021-pol2qm74 4250 1 Depts dept NNS cord-015021-pol2qm74 4250 2 of of IN cord-015021-pol2qm74 4250 3 Haem~ Haem~ NNP cord-015021-pol2qm74 4250 4 tology tology NNP cord-015021-pol2qm74 4250 5 & & CC cord-015021-pol2qm74 4250 6 Surgery Surgery NNP cord-015021-pol2qm74 4250 7 , , , cord-015021-pol2qm74 4250 8 Beaumont Beaumont NNP cord-015021-pol2qm74 4250 9 Hosoital Hosoital NNP cord-015021-pol2qm74 4250 10 , , , cord-015021-pol2qm74 4250 11 Dub!in Dub!in '' cord-015021-pol2qm74 4250 12 9,Eire 9,eire ADD cord-015021-pol2qm74 4250 13 . . . cord-015021-pol2qm74 4251 1 INTRODUCTION introduction NN cord-015021-pol2qm74 4251 2 : : : cord-015021-pol2qm74 4252 1 Loss loss NN cord-015021-pol2qm74 4252 2 of of IN cord-015021-pol2qm74 4252 3 cell cell NN cord-015021-pol2qm74 4252 4 membrane membrane NN cord-015021-pol2qm74 4252 5 integrity integrity NN cord-015021-pol2qm74 4252 6 appears appear VBZ cord-015021-pol2qm74 4252 7 to to TO cord-015021-pol2qm74 4252 8 be be VB cord-015021-pol2qm74 4252 9 a a DT cord-015021-pol2qm74 4252 10 common common JJ cord-015021-pol2qm74 4252 11 pathway pathway NN cord-015021-pol2qm74 4252 12 of of IN cord-015021-pol2qm74 4252 13 injury injury NN cord-015021-pol2qm74 4252 14 to to IN cord-015021-pol2qm74 4252 15 tissues tissue NNS cord-015021-pol2qm74 4252 16 subjected subject VBN cord-015021-pol2qm74 4252 17 to to IN cord-015021-pol2qm74 4252 18 high high JJ cord-015021-pol2qm74 4252 19 - - HYPH cord-015021-pol2qm74 4252 20 voltage voltage NN cord-015021-pol2qm74 4252 21 electrical electrical JJ cord-015021-pol2qm74 4252 22 shock shock NN cord-015021-pol2qm74 4252 23 . . . cord-015021-pol2qm74 4253 1 The the DT cord-015021-pol2qm74 4253 2 cell cell NN cord-015021-pol2qm74 4253 3 membrane membrane NN cord-015021-pol2qm74 4253 4 is be VBZ cord-015021-pol2qm74 4253 5 the the DT cord-015021-pol2qm74 4253 6 most most JJS cord-015021-pol2qm74 4253 7 heat heat NN cord-015021-pol2qm74 4253 8 labile labile JJ cord-015021-pol2qm74 4253 9 structure structure NN cord-015021-pol2qm74 4253 10 in in IN cord-015021-pol2qm74 4253 11 the the DT cord-015021-pol2qm74 4253 12 cell cell NN cord-015021-pol2qm74 4253 13 , , , cord-015021-pol2qm74 4253 14 and and CC cord-015021-pol2qm74 4253 15 is be VBZ cord-015021-pol2qm74 4253 16 also also RB cord-015021-pol2qm74 4253 17 the the DT cord-015021-pol2qm74 4253 18 most most RBS cord-015021-pol2qm74 4253 19 vulnerable vulnerable JJ cord-015021-pol2qm74 4253 20 to to IN cord-015021-pol2qm74 4253 21 externally externally RB cord-015021-pol2qm74 4253 22 - - HYPH cord-015021-pol2qm74 4253 23 imposed impose VBN cord-015021-pol2qm74 4253 24 electrical electrical JJ cord-015021-pol2qm74 4253 25 forces force NNS cord-015021-pol2qm74 4253 26 . . . cord-015021-pol2qm74 4254 1 Skeletal skeletal JJ cord-015021-pol2qm74 4254 2 muscle muscle NN cord-015021-pol2qm74 4254 3 and and CC cord-015021-pol2qm74 4254 4 nerve nerve NN cord-015021-pol2qm74 4254 5 cells cell NNS cord-015021-pol2qm74 4254 6 are be VBP cord-015021-pol2qm74 4254 7 particularly particularly RB cord-015021-pol2qm74 4254 8 susceptible susceptible JJ cord-015021-pol2qm74 4254 9 to to IN cord-015021-pol2qm74 4254 10 electroporation electroporation NN cord-015021-pol2qm74 4254 11 by by IN cord-015021-pol2qm74 4254 12 clinically clinically RB cord-015021-pol2qm74 4254 13 relevant relevant JJ cord-015021-pol2qm74 4254 14 electric electric JJ cord-015021-pol2qm74 4254 15 fields field NNS cord-015021-pol2qm74 4254 16 . . . cord-015021-pol2qm74 4255 1 Restoration restoration NN cord-015021-pol2qm74 4255 2 of of IN cord-015021-pol2qm74 4255 3 membrane membrane NN cord-015021-pol2qm74 4255 4 integrity integrity NN cord-015021-pol2qm74 4255 5 is be VBZ cord-015021-pol2qm74 4255 6 essential essential JJ cord-015021-pol2qm74 4255 7 for for IN cord-015021-pol2qm74 4255 8 cell cell NN cord-015021-pol2qm74 4255 9 survival survival NN cord-015021-pol2qm74 4255 10 in in IN cord-015021-pol2qm74 4255 11 victims victim NNS cord-015021-pol2qm74 4255 12 of of IN cord-015021-pol2qm74 4255 13 electrical electrical JJ cord-015021-pol2qm74 4255 14 shock shock NN cord-015021-pol2qm74 4255 15 . . . cord-015021-pol2qm74 4256 1 We -PRON- PRP cord-015021-pol2qm74 4256 2 have have VBP cord-015021-pol2qm74 4256 3 studied study VBN cord-015021-pol2qm74 4256 4 the the DT cord-015021-pol2qm74 4256 5 effect effect NN cord-015021-pol2qm74 4256 6 of of IN cord-015021-pol2qm74 4256 7 non non JJ cord-015021-pol2qm74 4256 8 - - JJ cord-015021-pol2qm74 4256 9 ionic ionic JJ cord-015021-pol2qm74 4256 10 triblock triblock NN cord-015021-pol2qm74 4256 11 copolymers copolymer NNS cord-015021-pol2qm74 4256 12 ( ( -LRB- cord-015021-pol2qm74 4256 13 poloxamer poloxamer NNP cord-015021-pol2qm74 4256 14 class class NNP cord-015021-pol2qm74 4256 15 ) ) -RRB- cord-015021-pol2qm74 4256 16 on on IN cord-015021-pol2qm74 4256 17 the the DT cord-015021-pol2qm74 4256 18 transport transport NN cord-015021-pol2qm74 4256 19 properties property NNS cord-015021-pol2qm74 4256 20 of of IN cord-015021-pol2qm74 4256 21 isolated isolate VBN cord-015021-pol2qm74 4256 22 rat rat NN cord-015021-pol2qm74 4256 23 skeletal skeletal JJ cord-015021-pol2qm74 4256 24 muscle muscle NN cord-015021-pol2qm74 4256 25 cells cell NNS cord-015021-pol2qm74 4256 26 following follow VBG cord-015021-pol2qm74 4256 27 electroporation electroporation NN cord-015021-pol2qm74 4256 28 - - HYPH cord-015021-pol2qm74 4256 29 induced induce VBN cord-015021-pol2qm74 4256 30 membrane membrane NN cord-015021-pol2qm74 4256 31 disruption disruption NN cord-015021-pol2qm74 4256 32 . . . cord-015021-pol2qm74 4257 1 1 1 LS cord-015021-pol2qm74 4257 2 - - SYM cord-015021-pol2qm74 4257 3 3 3 CD cord-015021-pol2qm74 4257 4 mm mm NN cord-015021-pol2qm74 4257 5 long long JJ cord-015021-pol2qm74 4257 6 adult adult NN cord-015021-pol2qm74 4257 7 skeletal skeletal JJ cord-015021-pol2qm74 4257 8 muscle muscle NN cord-015021-pol2qm74 4257 9 fibers fiber NNS cord-015021-pol2qm74 4257 10 were be VBD cord-015021-pol2qm74 4257 11 isolated isolate VBN cord-015021-pol2qm74 4257 12 by by IN cord-015021-pol2qm74 4257 13 enzymatic enzymatic JJ cord-015021-pol2qm74 4257 14 digestion digestion NN cord-015021-pol2qm74 4257 15 from from IN cord-015021-pol2qm74 4257 16 the the DT cord-015021-pol2qm74 4257 17 rat rat NN cord-015021-pol2qm74 4257 18 Flexor Flexor NNP cord-015021-pol2qm74 4257 19 Digitorium Digitorium NNP cord-015021-pol2qm74 4257 20 Brevus Brevus NNP cord-015021-pol2qm74 4257 21 and and CC cord-015021-pol2qm74 4257 22 maintained maintain VBN cord-015021-pol2qm74 4257 23 under under IN cord-015021-pol2qm74 4257 24 standard standard JJ cord-015021-pol2qm74 4257 25 culture culture NN cord-015021-pol2qm74 4257 26 conditions condition NNS cord-015021-pol2qm74 4257 27 . . . cord-015021-pol2qm74 4258 1 They -PRON- PRP cord-015021-pol2qm74 4258 2 were be VBD cord-015021-pol2qm74 4258 3 loaded load VBN cord-015021-pol2qm74 4258 4 with with IN cord-015021-pol2qm74 4258 5 the the DT cord-015021-pol2qm74 4258 6 Calcein Calcein NNP cord-015021-pol2qm74 4258 7 - - HYPH cord-015021-pol2qm74 4258 8 AM am NN cord-015021-pol2qm74 4258 9 dye dye NN cord-015021-pol2qm74 4258 10 and and CC cord-015021-pol2qm74 4258 11 placed place VBN cord-015021-pol2qm74 4258 12 in in IN cord-015021-pol2qm74 4258 13 a a DT cord-015021-pol2qm74 4258 14 37,C 37,c CD cord-015021-pol2qm74 4258 15 chamber chamber NN cord-015021-pol2qm74 4258 16 for for IN cord-015021-pol2qm74 4258 17 recording record VBG cord-015021-pol2qm74 4258 18 by by IN cord-015021-pol2qm74 4258 19 real real JJ cord-015021-pol2qm74 4258 20 - - HYPH cord-015021-pol2qm74 4258 21 time time NN cord-015021-pol2qm74 4258 22 video video NN cord-015021-pol2qm74 4258 23 confocal confocal JJ cord-015021-pol2qm74 4258 24 microscopy microscopy NNS cord-015021-pol2qm74 4258 25 . . . cord-015021-pol2qm74 4259 1 The the DT cord-015021-pol2qm74 4259 2 cells cell NNS cord-015021-pol2qm74 4259 3 were be VBD cord-015021-pol2qm74 4259 4 subjected subject VBN cord-015021-pol2qm74 4259 5 to to IN cord-015021-pol2qm74 4259 6 4 4 CD cord-015021-pol2qm74 4259 7 mSec mSec NNP cord-015021-pol2qm74 4259 8 , , , cord-015021-pol2qm74 4259 9 150 150 CD cord-015021-pol2qm74 4259 10 V v NN cord-015021-pol2qm74 4259 11 / / SYM cord-015021-pol2qm74 4259 12 era era NN cord-015021-pol2qm74 4259 13 , , , cord-015021-pol2qm74 4259 14 1 1 CD cord-015021-pol2qm74 4259 15 A a DT cord-015021-pol2qm74 4259 16 field field NN cord-015021-pol2qm74 4259 17 pulses pulse VBZ cord-015021-pol2qm74 4259 18 with with IN cord-015021-pol2qm74 4259 19 a a DT cord-015021-pol2qm74 4259 20 low low JJ cord-015021-pol2qm74 4259 21 duty duty NN cord-015021-pol2qm74 4259 22 cycle cycle NN cord-015021-pol2qm74 4259 23 to to TO cord-015021-pol2qm74 4259 24 allow allow VB cord-015021-pol2qm74 4259 25 thermal thermal JJ cord-015021-pol2qm74 4259 26 relaxation relaxation NN cord-015021-pol2qm74 4259 27 . . . cord-015021-pol2qm74 4260 1 Peak peak NN cord-015021-pol2qm74 4260 2 temperature temperature NN cord-015021-pol2qm74 4260 3 rise rise NN cord-015021-pol2qm74 4260 4 was be VBD cord-015021-pol2qm74 4260 5 0,2.C. 0,2.c. CD cord-015021-pol2qm74 4261 1 The the DT cord-015021-pol2qm74 4261 2 uye uye NN cord-015021-pol2qm74 4261 3 content content NN cord-015021-pol2qm74 4261 4 of of IN cord-015021-pol2qm74 4261 5 the the DT cord-015021-pol2qm74 4261 6 cell cell NN cord-015021-pol2qm74 4261 7 was be VBD cord-015021-pol2qm74 4261 8 monitored monitor VBN cord-015021-pol2qm74 4261 9 in in IN cord-015021-pol2qm74 4261 10 real real JJ cord-015021-pol2qm74 4261 11 time time NN cord-015021-pol2qm74 4261 12 . . . cord-015021-pol2qm74 4262 1 Experiments experiment NNS cord-015021-pol2qm74 4262 2 were be VBD cord-015021-pol2qm74 4262 3 carried carry VBN cord-015021-pol2qm74 4262 4 out out RP cord-015021-pol2qm74 4262 5 in in IN cord-015021-pol2qm74 4262 6 calcium calcium NN cord-015021-pol2qm74 4262 7 - - HYPH cord-015021-pol2qm74 4262 8 free free JJ cord-015021-pol2qm74 4262 9 phosphate phosphate NN cord-015021-pol2qm74 4262 10 buffered buffer VBN cord-015021-pol2qm74 4262 11 saline saline NN cord-015021-pol2qm74 4262 12 , , , cord-015021-pol2qm74 4262 13 with with IN cord-015021-pol2qm74 4262 14 1 1 CD cord-015021-pol2qm74 4262 15 mM mm CD cord-015021-pol2qm74 4262 16 Mg% Mg% NNP cord-015021-pol2qm74 4262 17 . . . cord-015021-pol2qm74 4263 1 Experiments experiment NNS cord-015021-pol2qm74 4263 2 were be VBD cord-015021-pol2qm74 4263 3 repeated repeat VBN cord-015021-pol2qm74 4263 4 with with IN cord-015021-pol2qm74 4263 5 4 4 CD cord-015021-pol2qm74 4263 6 mM mm CD cord-015021-pol2qm74 4263 7 neutral neutral JJ cord-015021-pol2qm74 4263 8 dextran dextran NN cord-015021-pol2qm74 4263 9 ( ( -LRB- cord-015021-pol2qm74 4263 10 The the DT cord-015021-pol2qm74 4263 11 aim aim NN cord-015021-pol2qm74 4263 12 of of IN cord-015021-pol2qm74 4263 13 the the DT cord-015021-pol2qm74 4263 14 present present JJ cord-015021-pol2qm74 4263 15 paper paper NN cord-015021-pol2qm74 4263 16 is be VBZ cord-015021-pol2qm74 4263 17 to to TO cord-015021-pol2qm74 4263 18 ascertain ascertain VB cord-015021-pol2qm74 4263 19 if if IN cord-015021-pol2qm74 4263 20 thuracotomy thuracotomy NN cord-015021-pol2qm74 4263 21 induces induce VBZ cord-015021-pol2qm74 4263 22 a a DT cord-015021-pol2qm74 4263 23 different different JJ cord-015021-pol2qm74 4263 24 pattern pattern NN cord-015021-pol2qm74 4263 25 of of IN cord-015021-pol2qm74 4263 26 variations variation NNS cord-015021-pol2qm74 4263 27 of of IN cord-015021-pol2qm74 4263 28 cytokines cytokine NNS cord-015021-pol2qm74 4263 29 , , , cord-015021-pol2qm74 4263 30 immunocompetent immunocompetent JJ cord-015021-pol2qm74 4263 31 cells cell NNS cord-015021-pol2qm74 4263 32 and and CC cord-015021-pol2qm74 4263 33 antibodies antibody NNS cord-015021-pol2qm74 4263 34 from from IN cord-015021-pol2qm74 4263 35 laparotomy laparotomy NN cord-015021-pol2qm74 4263 36 in in IN cord-015021-pol2qm74 4263 37 the the DT cord-015021-pol2qm74 4263 38 early early JJ cord-015021-pol2qm74 4263 39 postoperative postoperative JJ cord-015021-pol2qm74 4263 40 period period NN cord-015021-pol2qm74 4263 41 . . . cord-015021-pol2qm74 4264 1 60 60 CD cord-015021-pol2qm74 4264 2 patients patient NNS cord-015021-pol2qm74 4264 3 ( ( -LRB- cord-015021-pol2qm74 4264 4 34 34 CD cord-015021-pol2qm74 4264 5 males male NNS cord-015021-pol2qm74 4264 6 26 26 CD cord-015021-pol2qm74 4264 7 females female NNS cord-015021-pol2qm74 4264 8 , , , cord-015021-pol2qm74 4264 9 mean mean VB cord-015021-pol2qm74 4264 10 age age NN cord-015021-pol2qm74 4264 11 : : : cord-015021-pol2qm74 4264 12 59.5_+5 59.5_+5 CD cord-015021-pol2qm74 4264 13 ) ) -RRB- cord-015021-pol2qm74 4264 14 30 30 CD cord-015021-pol2qm74 4264 15 with with IN cord-015021-pol2qm74 4264 16 gallstone gallstone NN cord-015021-pol2qm74 4264 17 disease disease NN cord-015021-pol2qm74 4264 18 and and CC cord-015021-pol2qm74 4264 19 30 30 CD cord-015021-pol2qm74 4264 20 with with IN cord-015021-pol2qm74 4264 21 non non JJ cord-015021-pol2qm74 4264 22 neoplastic neoplastic JJ cord-015021-pol2qm74 4264 23 pulmonary pulmonary JJ cord-015021-pol2qm74 4264 24 disease disease NN cord-015021-pol2qm74 4264 25 were be VBD cord-015021-pol2qm74 4264 26 studied study VBN cord-015021-pol2qm74 4264 27 . . . cord-015021-pol2qm74 4265 1 None none NN cord-015021-pol2qm74 4265 2 of of IN cord-015021-pol2qm74 4265 3 these these DT cord-015021-pol2qm74 4265 4 patients patient NNS cord-015021-pol2qm74 4265 5 received receive VBD cord-015021-pol2qm74 4265 6 blood blood NN cord-015021-pol2qm74 4265 7 transfusion transfusion NN cord-015021-pol2qm74 4265 8 , , , cord-015021-pol2qm74 4265 9 biological biological JJ cord-015021-pol2qm74 4265 10 response response NN cord-015021-pol2qm74 4265 11 modifiers modifier NNS cord-015021-pol2qm74 4265 12 , , , cord-015021-pol2qm74 4265 13 radiotherapy radiotherapy NN cord-015021-pol2qm74 4265 14 or or CC cord-015021-pol2qm74 4265 15 surgery surgery NN cord-015021-pol2qm74 4265 16 for for IN cord-015021-pol2qm74 4265 17 at at RB cord-015021-pol2qm74 4265 18 least least RBS cord-015021-pol2qm74 4265 19 6 6 CD cord-015021-pol2qm74 4265 20 months month NNS cord-015021-pol2qm74 4265 21 before before IN cord-015021-pol2qm74 4265 22 being be VBG cord-015021-pol2qm74 4265 23 included include VBN cord-015021-pol2qm74 4265 24 in in IN cord-015021-pol2qm74 4265 25 our -PRON- PRP$ cord-015021-pol2qm74 4265 26 study study NN cord-015021-pol2qm74 4265 27 . . . cord-015021-pol2qm74 4266 1 Anaesthetic anaesthetic JJ cord-015021-pol2qm74 4266 2 procedures procedure NNS cord-015021-pol2qm74 4266 3 were be VBD cord-015021-pol2qm74 4266 4 similar similar JJ cord-015021-pol2qm74 4266 5 in in IN cord-015021-pol2qm74 4266 6 all all DT cord-015021-pol2qm74 4266 7 patients patient NNS cord-015021-pol2qm74 4266 8 and and CC cord-015021-pol2qm74 4266 9 none none NN cord-015021-pol2qm74 4266 10 were be VBD cord-015021-pol2qm74 4266 11 matnourished matnourishe VBN cord-015021-pol2qm74 4266 12 . . . cord-015021-pol2qm74 4267 1 On on IN cord-015021-pol2qm74 4267 2 the the DT cord-015021-pol2qm74 4267 3 day day NN cord-015021-pol2qm74 4267 4 of of IN cord-015021-pol2qm74 4267 5 surgery surgery NN cord-015021-pol2qm74 4267 6 and and CC cord-015021-pol2qm74 4267 7 on on IN cord-015021-pol2qm74 4267 8 the the DT cord-015021-pol2qm74 4267 9 1st 1st JJ cord-015021-pol2qm74 4267 10 and and CC cord-015021-pol2qm74 4267 11 7th 7th JJ cord-015021-pol2qm74 4267 12 postoperative postoperative JJ cord-015021-pol2qm74 4267 13 days day NNS cord-015021-pol2qm74 4267 14 ( ( -LRB- cord-015021-pol2qm74 4267 15 Pre Pre NNP cord-015021-pol2qm74 4267 16 , , , cord-015021-pol2qm74 4267 17 lPO lPO NNP cord-015021-pol2qm74 4267 18 , , , cord-015021-pol2qm74 4267 19 7PO 7PO NNP cord-015021-pol2qm74 4267 20 ) ) -RRB- cord-015021-pol2qm74 4267 21 percentages percentage NNS cord-015021-pol2qm74 4267 22 of of IN cord-015021-pol2qm74 4267 23 CD19 CD19 NNP cord-015021-pol2qm74 4267 24 , , , cord-015021-pol2qm74 4267 25 CD5 CD5 NNP cord-015021-pol2qm74 4267 26 , , , cord-015021-pol2qm74 4267 27 CD4 CD4 NNP cord-015021-pol2qm74 4267 28 , , , cord-015021-pol2qm74 4267 29 CDS CDS NNP cord-015021-pol2qm74 4267 30 , , , cord-015021-pol2qm74 4267 31 CDI6 CDI6 NNP cord-015021-pol2qm74 4267 32 were be VBD cord-015021-pol2qm74 4267 33 measured measure VBN cord-015021-pol2qm74 4267 34 by by IN cord-015021-pol2qm74 4267 35 means mean NNS cord-015021-pol2qm74 4267 36 of of IN cord-015021-pol2qm74 4267 37 flow flow NN cord-015021-pol2qm74 4267 38 cytometry cytometry NN cord-015021-pol2qm74 4267 39 using use VBG cord-015021-pol2qm74 4267 40 MoAb MoAb NNP cord-015021-pol2qm74 4267 41 . . NNP cord-015021-pol2qm74 4267 42 , , , cord-015021-pol2qm74 4267 43 and and CC cord-015021-pol2qm74 4267 44 levels level NNS cord-015021-pol2qm74 4267 45 of of IN cord-015021-pol2qm74 4267 46 Ig Ig NNP cord-015021-pol2qm74 4267 47 A A NNP cord-015021-pol2qm74 4267 48 , , , cord-015021-pol2qm74 4267 49 lgG lgG NNP cord-015021-pol2qm74 4267 50 , , , cord-015021-pol2qm74 4267 51 IgM IgM NNP cord-015021-pol2qm74 4267 52 , , , cord-015021-pol2qm74 4267 53 IgE. IgE. NNP cord-015021-pol2qm74 4267 54 by by IN cord-015021-pol2qm74 4267 55 nephelometry nephelometry NNP cord-015021-pol2qm74 4267 56 Cytokine Cytokine NNP cord-015021-pol2qm74 4267 57 levels level NNS cord-015021-pol2qm74 4267 58 in in IN cord-015021-pol2qm74 4267 59 peripheral peripheral JJ cord-015021-pol2qm74 4267 60 blood(IL-1 blood(IL-1 NNS cord-015021-pol2qm74 4267 61 , , , cord-015021-pol2qm74 4267 62 IL-2 IL-2 NNP cord-015021-pol2qm74 4267 63 , , , cord-015021-pol2qm74 4267 64 IL-4 IL-4 NNP cord-015021-pol2qm74 4267 65 , , , cord-015021-pol2qm74 4267 66 IL-6 IL-6 NNP cord-015021-pol2qm74 4267 67 , , , cord-015021-pol2qm74 4267 68 TNF TNF NNP cord-015021-pol2qm74 4267 69 ) ) -RRB- cord-015021-pol2qm74 4267 70 were be VBD cord-015021-pol2qm74 4267 71 measured measure VBN cord-015021-pol2qm74 4267 72 in in IN cord-015021-pol2qm74 4267 73 10 10 CD cord-015021-pol2qm74 4267 74 pts pt NNS cord-015021-pol2qm74 4267 75 . . . cord-015021-pol2qm74 4268 1 of of IN cord-015021-pol2qm74 4268 2 each each DT cord-015021-pol2qm74 4268 3 group group NN cord-015021-pol2qm74 4268 4 by by IN cord-015021-pol2qm74 4268 5 means mean NNS cord-015021-pol2qm74 4268 6 of of IN cord-015021-pol2qm74 4268 7 ELISA ELISA NNP cord-015021-pol2qm74 4268 8 using use VBG cord-015021-pol2qm74 4268 9 MoAb MoAb NNP cord-015021-pol2qm74 4268 10 . . . cord-015021-pol2qm74 4269 1 _ _ NNP cord-015021-pol2qm74 4270 1 R. R. NNP cord-015021-pol2qm74 4270 2 ESULTS ESULTS NNP cord-015021-pol2qm74 4270 3 : : : cord-015021-pol2qm74 4271 1 Variations variation NNS cord-015021-pol2qm74 4271 2 of of IN cord-015021-pol2qm74 4271 3 iL-2 il-2 NN cord-015021-pol2qm74 4271 4 and and CC cord-015021-pol2qm74 4272 1 IL-4 IL-4 NNP cord-015021-pol2qm74 4272 2 were be VBD cord-015021-pol2qm74 4272 3 not not RB cord-015021-pol2qm74 4272 4 s.s s.s NNP cord-015021-pol2qm74 4272 5 .. .. . cord-015021-pol2qm74 4273 1 IL-6 IL-6 NNP cord-015021-pol2qm74 4273 2 increased increase VBD cord-015021-pol2qm74 4273 3 but but CC cord-015021-pol2qm74 4273 4 differences difference NNS cord-015021-pol2qm74 4273 5 between between IN cord-015021-pol2qm74 4273 6 groups group NNS cord-015021-pol2qm74 4273 7 were be VBD cord-015021-pol2qm74 4273 8 not not RB cord-015021-pol2qm74 4273 9 statistically statistically RB cord-015021-pol2qm74 4273 10 significant significant JJ cord-015021-pol2qm74 4273 11 ( ( -LRB- cord-015021-pol2qm74 4273 12 s.s s.s NNP cord-015021-pol2qm74 4273 13 ) ) -RRB- cord-015021-pol2qm74 4273 14 . . . cord-015021-pol2qm74 4274 1 IL IL NNP cord-015021-pol2qm74 4274 2 - - : cord-015021-pol2qm74 4274 3 I -PRON- PRP cord-015021-pol2qm74 4274 4 decreased decrease VBD cord-015021-pol2qm74 4274 5 on on IN cord-015021-pol2qm74 4274 6 1PO 1po CD cord-015021-pol2qm74 4274 7 and and CC cord-015021-pol2qm74 4274 8 increased increase VBD cord-015021-pol2qm74 4274 9 on on IN cord-015021-pol2qm74 4274 10 7PO 7PO NNP cord-015021-pol2qm74 4274 11 in in IN cord-015021-pol2qm74 4274 12 both both DT cord-015021-pol2qm74 4274 13 groups group NNS cord-015021-pol2qm74 4274 14 but but CC cord-015021-pol2qm74 4274 15 were be VBD cord-015021-pol2qm74 4274 16 only only RB cord-015021-pol2qm74 4274 17 s.s s.s NNP cord-015021-pol2qm74 4274 18 . . NNP cord-015021-pol2qm74 4274 19 in in IN cord-015021-pol2qm74 4274 20 the the DT cord-015021-pol2qm74 4274 21 TH.g TH.g NNP cord-015021-pol2qm74 4274 22 . . NNP cord-015021-pol2qm74 4274 23 , , , cord-015021-pol2qm74 4274 24 and and CC cord-015021-pol2qm74 4274 25 therefore therefore RB cord-015021-pol2qm74 4274 26 , , , cord-015021-pol2qm74 4274 27 the the DT cord-015021-pol2qm74 4274 28 differences difference NNS cord-015021-pol2qm74 4274 29 between between IN cord-015021-pol2qm74 4274 30 groups group NNS cord-015021-pol2qm74 4274 31 were be VBD cord-015021-pol2qm74 4275 1 s.s s.s NNP cord-015021-pol2qm74 4275 2 ( ( -LRB- cord-015021-pol2qm74 4275 3 P<0.05).TNF P<0.05).TNF NNP cord-015021-pol2qm74 4275 4 decreased decrease VBD cord-015021-pol2qm74 4275 5 in in IN cord-015021-pol2qm74 4275 6 the the DT cord-015021-pol2qm74 4275 7 L.g l.g NN cord-015021-pol2qm74 4275 8 . . . cord-015021-pol2qm74 4276 1 and and CC cord-015021-pol2qm74 4276 2 increased increase VBD cord-015021-pol2qm74 4276 3 in in IN cord-015021-pol2qm74 4276 4 the the DT cord-015021-pol2qm74 4276 5 Th.g Th.g NNP cord-015021-pol2qm74 4276 6 . . . cord-015021-pol2qm74 4277 1 on on IN cord-015021-pol2qm74 4277 2 the the DT cord-015021-pol2qm74 4277 3 1PO 1po CD cord-015021-pol2qm74 4277 4 , , , cord-015021-pol2qm74 4277 5 the the DT cord-015021-pol2qm74 4277 6 difference difference NN cord-015021-pol2qm74 4277 7 was be VBD cord-015021-pol2qm74 4277 8 s.s(P<0.05 s.s(P<0.05 NNP cord-015021-pol2qm74 4277 9 ) ) -RRB- cord-015021-pol2qm74 4277 10 ; ; : cord-015021-pol2qm74 4277 11 on on IN cord-015021-pol2qm74 4277 12 7PO 7PO NNP cord-015021-pol2qm74 4277 13 , , , cord-015021-pol2qm74 4277 14 TNF TNF NNP cord-015021-pol2qm74 4277 15 decreased decrease VBD cord-015021-pol2qm74 4277 16 in in IN cord-015021-pol2qm74 4277 17 the the DT cord-015021-pol2qm74 4277 18 L.g l.g NN cord-015021-pol2qm74 4277 19 . . . cord-015021-pol2qm74 4278 1 and and CC cord-015021-pol2qm74 4278 2 decreased decrease VBD cord-015021-pol2qm74 4278 3 in in IN cord-015021-pol2qm74 4278 4 the the DT cord-015021-pol2qm74 4278 5 TH.g TH.g NNP cord-015021-pol2qm74 4278 6 . . . cord-015021-pol2qm74 4279 1 but but CC cord-015021-pol2qm74 4279 2 these these DT cord-015021-pol2qm74 4279 3 variations variation NNS cord-015021-pol2qm74 4279 4 were be VBD cord-015021-pol2qm74 4279 5 not not RB cord-015021-pol2qm74 4279 6 s.s s.s NNP cord-015021-pol2qm74 4279 7 . . . cord-015021-pol2qm74 4280 1 Cell cell NN cord-015021-pol2qm74 4280 2 percentages percentage NNS cord-015021-pol2qm74 4280 3 decreased decrease VBD cord-015021-pol2qm74 4280 4 an an DT cord-015021-pol2qm74 4280 5 lPO lpo NN cord-015021-pol2qm74 4280 6 and and CC cord-015021-pol2qm74 4280 7 increased increase VBD cord-015021-pol2qm74 4280 8 on on IN cord-015021-pol2qm74 4280 9 7PO 7PO NNP cord-015021-pol2qm74 4280 10 , , , cord-015021-pol2qm74 4280 11 except except IN cord-015021-pol2qm74 4280 12 for for IN cord-015021-pol2qm74 4280 13 % % NN cord-015021-pol2qm74 4280 14 CD19 CD19 NNP cord-015021-pol2qm74 4280 15 cell cell NN cord-015021-pol2qm74 4280 16 that that WDT cord-015021-pol2qm74 4280 17 increased increase VBD cord-015021-pol2qm74 4280 18 on on IN cord-015021-pol2qm74 4280 19 lPO lpo NN cord-015021-pol2qm74 4280 20 and and CC cord-015021-pol2qm74 4280 21 decreased decrease VBD cord-015021-pol2qm74 4280 22 on on IN cord-015021-pol2qm74 4280 23 7PO 7PO NNP cord-015021-pol2qm74 4280 24 , , , cord-015021-pol2qm74 4280 25 in in IN cord-015021-pol2qm74 4280 26 both both DT cord-015021-pol2qm74 4280 27 groups group NNS cord-015021-pol2qm74 4280 28 of of IN cord-015021-pol2qm74 4280 29 pts pt NNS cord-015021-pol2qm74 4280 30 . . . cord-015021-pol2qm74 4281 1 Differences difference NNS cord-015021-pol2qm74 4281 2 were be VBD cord-015021-pol2qm74 4281 3 not not RB cord-015021-pol2qm74 4281 4 s.s s.s NNP cord-015021-pol2qm74 4281 5 . . . cord-015021-pol2qm74 4282 1 Ig Ig NNP cord-015021-pol2qm74 4282 2 A A NNP cord-015021-pol2qm74 4282 3 , , , cord-015021-pol2qm74 4282 4 IgM IgM NNP cord-015021-pol2qm74 4282 5 decreased decrease VBD cord-015021-pol2qm74 4282 6 and and CC cord-015021-pol2qm74 4282 7 IgE IgE NNP cord-015021-pol2qm74 4282 8 increased increase VBD cord-015021-pol2qm74 4282 9 in in IN cord-015021-pol2qm74 4282 10 both both DT cord-015021-pol2qm74 4282 11 groups group NNS cord-015021-pol2qm74 4282 12 ( ( -LRB- cord-015021-pol2qm74 4282 13 P p NN cord-015021-pol2qm74 4282 14 < < XX cord-015021-pol2qm74 4282 15 0.0i 0.0i CD cord-015021-pol2qm74 4282 16 ) ) -RRB- cord-015021-pol2qm74 4282 17 , , , cord-015021-pol2qm74 4282 18 but but CC cord-015021-pol2qm74 4282 19 differences difference NNS cord-015021-pol2qm74 4282 20 between between IN cord-015021-pol2qm74 4282 21 them -PRON- PRP cord-015021-pol2qm74 4282 22 were be VBD cord-015021-pol2qm74 4282 23 not not RB cord-015021-pol2qm74 4282 24 s.s s.s NNP cord-015021-pol2qm74 4282 25 . . . cord-015021-pol2qm74 4283 1 In in IN cord-015021-pol2qm74 4283 2 contrast contrast NN cord-015021-pol2qm74 4283 3 , , , cord-015021-pol2qm74 4283 4 IgG igg NN cord-015021-pol2qm74 4283 5 decreased decrease VBD cord-015021-pol2qm74 4283 6 on on IN cord-015021-pol2qm74 4283 7 1PO 1po CD cord-015021-pol2qm74 4283 8 ( ( -LRB- cord-015021-pol2qm74 4283 9 P<0.01 P<0.01 NNP cord-015021-pol2qm74 4283 10 ) ) -RRB- cord-015021-pol2qm74 4283 11 and and CC cord-015021-pol2qm74 4283 12 increased increase VBD cord-015021-pol2qm74 4283 13 on on IN cord-015021-pol2qm74 4283 14 7PO 7PO NNP cord-015021-pol2qm74 4283 15 in in IN cord-015021-pol2qm74 4283 16 both both DT cord-015021-pol2qm74 4283 17 groups group NNS cord-015021-pol2qm74 4283 18 , , , cord-015021-pol2qm74 4283 19 but but CC cord-015021-pol2qm74 4283 20 the the DT cord-015021-pol2qm74 4283 21 decrease decrease NN cord-015021-pol2qm74 4283 22 iu iu IN cord-015021-pol2qm74 4283 23 the the DT cord-015021-pol2qm74 4283 24 TH.g TH.g NNP cord-015021-pol2qm74 4283 25 . . . cord-015021-pol2qm74 4283 26 was be VBD cord-015021-pol2qm74 4283 27 greater great JJR cord-015021-pol2qm74 4283 28 than than IN cord-015021-pol2qm74 4283 29 in in IN cord-015021-pol2qm74 4283 30 the the DT cord-015021-pol2qm74 4283 31 L.g l.g NN cord-015021-pol2qm74 4283 32 . . . cord-015021-pol2qm74 4284 1 Twenty twenty CD cord-015021-pol2qm74 4284 2 male male JJ cord-015021-pol2qm74 4284 3 children child NNS cord-015021-pol2qm74 4284 4 , , , cord-015021-pol2qm74 4284 5 aged age VBN cord-015021-pol2qm74 4284 6 from from IN cord-015021-pol2qm74 4284 7 six six CD cord-015021-pol2qm74 4284 8 months month NNS cord-015021-pol2qm74 4284 9 to to IN cord-015021-pol2qm74 4284 10 3 3 CD cord-015021-pol2qm74 4284 11 years year NNS cord-015021-pol2qm74 4284 12 , , , cord-015021-pol2qm74 4284 13 admitted admit VBN cord-015021-pol2qm74 4284 14 for for IN cord-015021-pol2qm74 4284 15 elective elective JJ cord-015021-pol2qm74 4284 16 inguinal inguinal JJ cord-015021-pol2qm74 4284 17 operation operation NN cord-015021-pol2qm74 4284 18 were be VBD cord-015021-pol2qm74 4284 19 studied study VBN cord-015021-pol2qm74 4284 20 . . . cord-015021-pol2qm74 4285 1 The the DT cord-015021-pol2qm74 4285 2 operations operation NNS cord-015021-pol2qm74 4285 3 were be VBD cord-015021-pol2qm74 4285 4 performed perform VBN cord-015021-pol2qm74 4285 5 under under IN cord-015021-pol2qm74 4285 6 balanced balanced JJ cord-015021-pol2qm74 4285 7 combined combined JJ cord-015021-pol2qm74 4285 8 anaesthesia anaesthesia NN cord-015021-pol2qm74 4285 9 ( ( -LRB- cord-015021-pol2qm74 4285 10 fentanyl fentanyl NN cord-015021-pol2qm74 4285 11 , , , cord-015021-pol2qm74 4285 12 thiopemtone thiopemtone NN cord-015021-pol2qm74 4285 13 , , , cord-015021-pol2qm74 4285 14 vecuronium vecuronium NNP cord-015021-pol2qm74 4285 15 , , , cord-015021-pol2qm74 4285 16 70 70 CD cord-015021-pol2qm74 4285 17 % % NN cord-015021-pol2qm74 4285 18 nitrous nitrous JJ cord-015021-pol2qm74 4285 19 oxide oxide NN cord-015021-pol2qm74 4285 20 in in IN cord-015021-pol2qm74 4285 21 oxygen oxygen NN cord-015021-pol2qm74 4285 22 ) ) -RRB- cord-015021-pol2qm74 4285 23 and and CC cord-015021-pol2qm74 4285 24 blood blood NN cord-015021-pol2qm74 4285 25 samples sample NNS cord-015021-pol2qm74 4285 26 were be VBD cord-015021-pol2qm74 4285 27 collected collect VBN cord-015021-pol2qm74 4285 28 before before IN cord-015021-pol2qm74 4285 29 flunitrazepam flunitrazepam NN cord-015021-pol2qm74 4285 30 premedication premedication NN cord-015021-pol2qm74 4285 31 , , , cord-015021-pol2qm74 4285 32 after after IN cord-015021-pol2qm74 4285 33 anaesthesia,4 anaesthesia,4 NN cord-015021-pol2qm74 4285 34 and and CC cord-015021-pol2qm74 4285 35 24 24 CD cord-015021-pol2qm74 4285 36 hours hour NNS cord-015021-pol2qm74 4285 37 after after IN cord-015021-pol2qm74 4285 38 anaesthesia anaesthesia NN cord-015021-pol2qm74 4285 39 . . . cord-015021-pol2qm74 4286 1 Cells cell NNS cord-015021-pol2qm74 4286 2 from from IN cord-015021-pol2qm74 4286 3 the the DT cord-015021-pol2qm74 4286 4 wound wound NN cord-015021-pol2qm74 4286 5 were be VBD cord-015021-pol2qm74 4286 6 collected collect VBN cord-015021-pol2qm74 4286 7 with with IN cord-015021-pol2qm74 4286 8 Cellstick Cellstick NNP cord-015021-pol2qm74 4286 9 sponge sponge NN cord-015021-pol2qm74 4286 10 which which WDT cord-015021-pol2qm74 4286 11 was be VBD cord-015021-pol2qm74 4286 12 removed remove VBN cord-015021-pol2qm74 4286 13 from from IN cord-015021-pol2qm74 4286 14 the the DT cord-015021-pol2qm74 4286 15 wound wound NN cord-015021-pol2qm74 4286 16 4 4 CD cord-015021-pol2qm74 4286 17 or or CC cord-015021-pol2qm74 4286 18 24 24 CD cord-015021-pol2qm74 4286 19 hours hour NNS cord-015021-pol2qm74 4286 20 after after IN cord-015021-pol2qm74 4286 21 anaesthesia anaesthesia NN cord-015021-pol2qm74 4286 22 . . . cord-015021-pol2qm74 4287 1 The the DT cord-015021-pol2qm74 4287 2 study study NN cord-015021-pol2qm74 4287 3 was be VBD cord-015021-pol2qm74 4287 4 approved approve VBN cord-015021-pol2qm74 4287 5 by by IN cord-015021-pol2qm74 4287 6 the the DT cord-015021-pol2qm74 4287 7 local local JJ cord-015021-pol2qm74 4287 8 Ethical Ethical NNP cord-015021-pol2qm74 4287 9 Committee Committee NNP cord-015021-pol2qm74 4287 10 . . . cord-015021-pol2qm74 4288 1 The the DT cord-015021-pol2qm74 4288 2 percentage percentage NN cord-015021-pol2qm74 4288 3 of of IN cord-015021-pol2qm74 4288 4 neutrophils neutrophil NNS cord-015021-pol2qm74 4288 5 was be VBD cord-015021-pol2qm74 4288 6 increased increase VBN cord-015021-pol2qm74 4288 7 and and CC cord-015021-pol2qm74 4288 8 that that IN cord-015021-pol2qm74 4288 9 of of IN cord-015021-pol2qm74 4288 10 lymphocytes lymphocyte NNS cord-015021-pol2qm74 4288 11 was be VBD cord-015021-pol2qm74 4288 12 decreased decrease VBN cord-015021-pol2qm74 4288 13 in in IN cord-015021-pol2qm74 4288 14 perpheral perpheral JJ cord-015021-pol2qm74 4288 15 blood blood NN cord-015021-pol2qm74 4288 16 after after IN cord-015021-pol2qm74 4288 17 the the DT cord-015021-pol2qm74 4288 18 operation operation NN cord-015021-pol2qm74 4288 19 . . . cord-015021-pol2qm74 4289 1 The the DT cord-015021-pol2qm74 4289 2 values value NNS cord-015021-pol2qm74 4289 3 in in IN cord-015021-pol2qm74 4289 4 the the DT cord-015021-pol2qm74 4289 5 wound wound NN cord-015021-pol2qm74 4289 6 were be VBD cord-015021-pol2qm74 4289 7 close close JJ cord-015021-pol2qm74 4289 8 to to IN cord-015021-pol2qm74 4289 9 the the DT cord-015021-pol2qm74 4289 10 values value NNS cord-015021-pol2qm74 4289 11 found find VBN cord-015021-pol2qm74 4289 12 in in IN cord-015021-pol2qm74 4289 13 peripheral peripheral JJ cord-015021-pol2qm74 4289 14 blood blood NN cord-015021-pol2qm74 4289 15 . . . cord-015021-pol2qm74 4290 1 The the DT cord-015021-pol2qm74 4290 2 percentage percentage NN cord-015021-pol2qm74 4290 3 of of IN cord-015021-pol2qm74 4290 4 T t NN cord-015021-pol2qm74 4290 5 - - HYPH cord-015021-pol2qm74 4290 6 lymphocytes lymphocyte NNS cord-015021-pol2qm74 4290 7 ( ( -LRB- cord-015021-pol2qm74 4290 8 CD3 CD3 NNP cord-015021-pol2qm74 4290 9 ) ) -RRB- cord-015021-pol2qm74 4290 10 and and CC cord-015021-pol2qm74 4290 11 helper helper NN cord-015021-pol2qm74 4290 12 - - HYPH cord-015021-pol2qm74 4290 13 T t NN cord-015021-pol2qm74 4290 14 - - HYPH cord-015021-pol2qm74 4290 15 cells cell NNS cord-015021-pol2qm74 4290 16 ( ( -LRB- cord-015021-pol2qm74 4290 17 CD4 CD4 NNP cord-015021-pol2qm74 4290 18 ) ) -RRB- cord-015021-pol2qm74 4290 19 decreased decrease VBD cord-015021-pol2qm74 4290 20 in in IN cord-015021-pol2qm74 4290 21 peripheral peripheral JJ cord-015021-pol2qm74 4290 22 blood blood NN cord-015021-pol2qm74 4290 23 being be VBG cord-015021-pol2qm74 4290 24 lower low JJR cord-015021-pol2qm74 4290 25 in in IN cord-015021-pol2qm74 4290 26 the the DT cord-015021-pol2qm74 4290 27 wound wound NN cord-015021-pol2qm74 4290 28 than than IN cord-015021-pol2qm74 4290 29 in in IN cord-015021-pol2qm74 4290 30 peripheral peripheral JJ cord-015021-pol2qm74 4290 31 blood blood NN cord-015021-pol2qm74 4290 32 after after IN cord-015021-pol2qm74 4290 33 the the DT cord-015021-pol2qm74 4290 34 operation operation NN cord-015021-pol2qm74 4290 35 . . . cord-015021-pol2qm74 4291 1 The the DT cord-015021-pol2qm74 4291 2 percentage percentage NN cord-015021-pol2qm74 4291 3 of of IN cord-015021-pol2qm74 4291 4 T T NNP cord-015021-pol2qm74 4291 5 - - HYPH cord-015021-pol2qm74 4291 6 eytotoxic eytotoxic NNP cord-015021-pol2qm74 4291 7 cells cell NNS cord-015021-pol2qm74 4291 8 ( ( -LRB- cord-015021-pol2qm74 4291 9 CD8 CD8 NNP cord-015021-pol2qm74 4291 10 ) ) -RRB- cord-015021-pol2qm74 4291 11 also also RB cord-015021-pol2qm74 4291 12 decreased decrease VBD cord-015021-pol2qm74 4291 13 in in IN cord-015021-pol2qm74 4291 14 peripheral peripheral JJ cord-015021-pol2qm74 4291 15 blood blood NN cord-015021-pol2qm74 4291 16 and and CC cord-015021-pol2qm74 4291 17 was be VBD cord-015021-pol2qm74 4291 18 similar similar JJ cord-015021-pol2qm74 4291 19 to to IN cord-015021-pol2qm74 4291 20 that that DT cord-015021-pol2qm74 4291 21 in in IN cord-015021-pol2qm74 4291 22 the the DT cord-015021-pol2qm74 4291 23 wound wound NN cord-015021-pol2qm74 4291 24 . . . cord-015021-pol2qm74 4292 1 B b NN cord-015021-pol2qm74 4292 2 - - HYPH cord-015021-pol2qm74 4292 3 lymphocyte lymphocyte NN cord-015021-pol2qm74 4292 4 ( ( -LRB- cord-015021-pol2qm74 4292 5 CD19 CD19 NNP cord-015021-pol2qm74 4292 6 ) ) -RRB- cord-015021-pol2qm74 4292 7 percentage percentage NN cord-015021-pol2qm74 4292 8 was be VBD cord-015021-pol2qm74 4292 9 increased increase VBN cord-015021-pol2qm74 4292 10 in in IN cord-015021-pol2qm74 4292 11 pe pe NNP cord-015021-pol2qm74 4292 12 ~ ~ CD cord-015021-pol2qm74 4292 13 pheral pheral JJ cord-015021-pol2qm74 4292 14 blood blood NN cord-015021-pol2qm74 4292 15 after after IN cord-015021-pol2qm74 4292 16 the the DT cord-015021-pol2qm74 4292 17 operation operation NN cord-015021-pol2qm74 4292 18 and and CC cord-015021-pol2qm74 4292 19 was be VBD cord-015021-pol2qm74 4292 20 higher high JJR cord-015021-pol2qm74 4292 21 than than IN cord-015021-pol2qm74 4292 22 in in IN cord-015021-pol2qm74 4292 23 the the DT cord-015021-pol2qm74 4292 24 wound wound NN cord-015021-pol2qm74 4292 25 . . . cord-015021-pol2qm74 4293 1 The the DT cord-015021-pol2qm74 4293 2 percentage percentage NN cord-015021-pol2qm74 4293 3 of of IN cord-015021-pol2qm74 4293 4 activated activate VBN cord-015021-pol2qm74 4293 5 T T NNP cord-015021-pol2qm74 4293 6 - - HYPH cord-015021-pol2qm74 4293 7 cells cell NNS cord-015021-pol2qm74 4293 8 ( ( -LRB- cord-015021-pol2qm74 4293 9 CD3+HLA CD3+HLA NNP cord-015021-pol2qm74 4293 10 - - HYPH cord-015021-pol2qm74 4293 11 Dr Dr NNP cord-015021-pol2qm74 4293 12 - - HYPH cord-015021-pol2qm74 4293 13 positive positive JJ cord-015021-pol2qm74 4293 14 cells cell NNS cord-015021-pol2qm74 4293 15 ) ) -RRB- cord-015021-pol2qm74 4293 16 in in IN cord-015021-pol2qm74 4293 17 peripheral peripheral JJ cord-015021-pol2qm74 4293 18 blood blood NN cord-015021-pol2qm74 4293 19 increased increase VBD cord-015021-pol2qm74 4293 20 while while IN cord-015021-pol2qm74 4293 21 that that DT cord-015021-pol2qm74 4293 22 of of IN cord-015021-pol2qm74 4293 23 natural natural JJ cord-015021-pol2qm74 4293 24 killer killer NN cord-015021-pol2qm74 4293 25 cells cell NNS cord-015021-pol2qm74 4293 26 ( ( -LRB- cord-015021-pol2qm74 4293 27 CD3+CD16+Leu19-pos cd3+cd16+leu19-pos NN cord-015021-pol2qm74 4293 28 ) ) -RRB- cord-015021-pol2qm74 4293 29 was be VBD cord-015021-pol2qm74 4293 30 increased increase VBN cord-015021-pol2qm74 4293 31 just just RB cord-015021-pol2qm74 4293 32 after after IN cord-015021-pol2qm74 4293 33 anaesthesia anaesthesia NN cord-015021-pol2qm74 4293 34 being being NN cord-015021-pol2qm74 4293 35 decreased decrease VBD cord-015021-pol2qm74 4293 36 at at IN cord-015021-pol2qm74 4293 37 g g NN cord-015021-pol2qm74 4293 38 and and CC cord-015021-pol2qm74 4293 39 24 24 CD cord-015021-pol2qm74 4293 40 hours hour NNS cord-015021-pol2qm74 4293 41 after after IN cord-015021-pol2qm74 4293 42 the the DT cord-015021-pol2qm74 4293 43 operation operation NN cord-015021-pol2qm74 4293 44 . . . cord-015021-pol2qm74 4294 1 Spontaneous spontaneous JJ cord-015021-pol2qm74 4294 2 lymphocyte lymphocyte NN cord-015021-pol2qm74 4294 3 proliferative proliferative JJ cord-015021-pol2qm74 4294 4 responses response NNS cord-015021-pol2qm74 4294 5 did do VBD cord-015021-pol2qm74 4294 6 n't not RB cord-015021-pol2qm74 4294 7 change change VB cord-015021-pol2qm74 4294 8 while while IN cord-015021-pol2qm74 4294 9 phytohemagglutinin phytohemagglutinin NNP cord-015021-pol2qm74 4294 10 A A NNP cord-015021-pol2qm74 4294 11 and and CC cord-015021-pol2qm74 4294 12 concavalin concavalin NN cord-015021-pol2qm74 4294 13 A a DT cord-015021-pol2qm74 4294 14 induced induce VBN cord-015021-pol2qm74 4294 15 responses response NNS cord-015021-pol2qm74 4294 16 were be VBD cord-015021-pol2qm74 4294 17 decreased decrease VBN cord-015021-pol2qm74 4294 18 in in IN cord-015021-pol2qm74 4294 19 peripheral peripheral JJ cord-015021-pol2qm74 4294 20 blood blood NN cord-015021-pol2qm74 4294 21 samples sample NNS cord-015021-pol2qm74 4294 22 4 4 CD cord-015021-pol2qm74 4294 23 hours hour NNS cord-015021-pol2qm74 4294 24 after after IN cord-015021-pol2qm74 4294 25 the the DT cord-015021-pol2qm74 4294 26 operation operation NN cord-015021-pol2qm74 4294 27 with with IN cord-015021-pol2qm74 4294 28 recovery recovery NN cord-015021-pol2qm74 4294 29 at at IN cord-015021-pol2qm74 4294 30 24 24 CD cord-015021-pol2qm74 4294 31 hours hour NNS cord-015021-pol2qm74 4294 32 . . . cord-015021-pol2qm74 4295 1 Pokeweed pokeweed JJ cord-015021-pol2qm74 4295 2 mitogen mitogen NN cord-015021-pol2qm74 4295 3 induced induce VBN cord-015021-pol2qm74 4295 4 lymphocyte lymphocyte NN cord-015021-pol2qm74 4295 5 proliferative proliferative JJ cord-015021-pol2qm74 4295 6 responses response NNS cord-015021-pol2qm74 4295 7 were be VBD cord-015021-pol2qm74 4295 8 decreased decrease VBN cord-015021-pol2qm74 4295 9 at at IN cord-015021-pol2qm74 4295 10 4 4 CD cord-015021-pol2qm74 4295 11 hours hour NNS cord-015021-pol2qm74 4295 12 ( ( -LRB- cord-015021-pol2qm74 4295 13 p p NN cord-015021-pol2qm74 4295 14 < < XX cord-015021-pol2qm74 4295 15 O.01 o.01 CD cord-015021-pol2qm74 4295 16 ) ) -RRB- cord-015021-pol2qm74 4295 17 and and CC cord-015021-pol2qm74 4295 18 24 24 CD cord-015021-pol2qm74 4295 19 hours hour NNS cord-015021-pol2qm74 4295 20 after after IN cord-015021-pol2qm74 4295 21 the the DT cord-015021-pol2qm74 4295 22 operation operation NN cord-015021-pol2qm74 4296 1 We -PRON- PRP cord-015021-pol2qm74 4296 2 previously previously RB cord-015021-pol2qm74 4296 3 reported report VBD cord-015021-pol2qm74 4296 4 that that IN cord-015021-pol2qm74 4296 5 plasma plasma NNP cord-015021-pol2qm74 4296 6 IgE IgE NNP cord-015021-pol2qm74 4296 7 increased increase VBD cord-015021-pol2qm74 4296 8 after after IN cord-015021-pol2qm74 4296 9 traumatic traumatic JJ cord-015021-pol2qm74 4296 10 injury injury NN cord-015021-pol2qm74 4296 11 . . . cord-015021-pol2qm74 4297 1 In in IN cord-015021-pol2qm74 4297 2 this this DT cord-015021-pol2qm74 4297 3 study study NN cord-015021-pol2qm74 4297 4 , , , cord-015021-pol2qm74 4297 5 we -PRON- PRP cord-015021-pol2qm74 4297 6 measured measure VBD cord-015021-pol2qm74 4297 7 plasma plasma NNP cord-015021-pol2qm74 4297 8 IgE IgE NNP cord-015021-pol2qm74 4297 9 Ievels Ievels NNP cord-015021-pol2qm74 4297 10 in in IN cord-015021-pol2qm74 4297 11 40 40 CD cord-015021-pol2qm74 4297 12 trauma trauma NN cord-015021-pol2qm74 4297 13 patients patient NNS cord-015021-pol2qm74 4297 14 on on IN cord-015021-pol2qm74 4297 15 hospital hospital NN cord-015021-pol2qm74 4297 16 admission admission NN cord-015021-pol2qm74 4297 17 and and CC cord-015021-pol2qm74 4297 18 3x 3x CD cord-015021-pol2qm74 4297 19 weekly weekly NN cord-015021-pol2qm74 4297 20 in in IN cord-015021-pol2qm74 4297 21 the the DT cord-015021-pol2qm74 4297 22 intensive intensive JJ cord-015021-pol2qm74 4297 23 care care NN cord-015021-pol2qm74 4297 24 unit unit NN cord-015021-pol2qm74 4297 25 to to TO cord-015021-pol2qm74 4297 26 evaluate evaluate VB cord-015021-pol2qm74 4297 27 IgE IgE NNP cord-015021-pol2qm74 4297 28 kinetics kinetics NNP cord-015021-pol2qm74 4297 29 . . . cord-015021-pol2qm74 4298 1 Patient patient JJ cord-015021-pol2qm74 4298 2 characteristics characteristic NNS cord-015021-pol2qm74 4298 3 were be VBD cord-015021-pol2qm74 4298 4 : : : cord-015021-pol2qm74 4298 5 mean mean VB cord-015021-pol2qm74 4298 6 age age NN cord-015021-pol2qm74 4298 7 36-+ 36-+ CD cord-015021-pol2qm74 4298 8 16 16 CD cord-015021-pol2qm74 4298 9 years year NNS cord-015021-pol2qm74 4298 10 ( ( -LRB- cord-015021-pol2qm74 4298 11 33 33 CD cord-015021-pol2qm74 4298 12 m m NN cord-015021-pol2qm74 4298 13 , , , cord-015021-pol2qm74 4298 14 9 9 CD cord-015021-pol2qm74 4298 15 f f NNP cord-015021-pol2qm74 4298 16 ) ) -RRB- cord-015021-pol2qm74 4298 17 , , . cord-015021-pol2qm74 4299 1 mean mean VB cord-015021-pol2qm74 4299 2 Injury injury NN cord-015021-pol2qm74 4299 3 Severity severity NN cord-015021-pol2qm74 4299 4 Score score NN cord-015021-pol2qm74 4299 5 ( ( -LRB- cord-015021-pol2qm74 4299 6 ISS ISS NNP cord-015021-pol2qm74 4299 7 ) ) -RRB- cord-015021-pol2qm74 4299 8 26 26 CD cord-015021-pol2qm74 4299 9 + + SYM cord-015021-pol2qm74 4299 10 10 10 CD cord-015021-pol2qm74 4299 11 , , , cord-015021-pol2qm74 4299 12 sepsis sepsis NN cord-015021-pol2qm74 4299 13 ( ( -LRB- cord-015021-pol2qm74 4299 14 19 19 CD cord-015021-pol2qm74 4299 15 patients patient NNS cord-015021-pol2qm74 4299 16 ) ) -RRB- cord-015021-pol2qm74 4299 17 , , , cord-015021-pol2qm74 4299 18 sepsis sepsis NN cord-015021-pol2qm74 4299 19 syndrome syndrome NN cord-015021-pol2qm74 4299 20 ( ( -LRB- cord-015021-pol2qm74 4299 21 9 9 CD cord-015021-pol2qm74 4299 22 patients patient NNS cord-015021-pol2qm74 4299 23 ) ) -RRB- cord-015021-pol2qm74 4299 24 , , , cord-015021-pol2qm74 4299 25 ARDS ARDS NNP cord-015021-pol2qm74 4299 26 ( ( -LRB- cord-015021-pol2qm74 4299 27 4 4 CD cord-015021-pol2qm74 4299 28 patients patient NNS cord-015021-pol2qm74 4299 29 ) ) -RRB- cord-015021-pol2qm74 4299 30 , , , cord-015021-pol2qm74 4299 31 renal renal JJ cord-015021-pol2qm74 4299 32 failure failure NN cord-015021-pol2qm74 4299 33 ( ( -LRB- cord-015021-pol2qm74 4299 34 5 5 CD cord-015021-pol2qm74 4299 35 patients patient NNS cord-015021-pol2qm74 4299 36 ) ) -RRB- cord-015021-pol2qm74 4299 37 . . . cord-015021-pol2qm74 4300 1 IgE IgE NNP cord-015021-pol2qm74 4300 2 increased increase VBD cord-015021-pol2qm74 4300 3 in in IN cord-015021-pol2qm74 4300 4 28 28 CD cord-015021-pol2qm74 4300 5 patients patient NNS cord-015021-pol2qm74 4300 6 ( ( -LRB- cord-015021-pol2qm74 4300 7 70 70 CD cord-015021-pol2qm74 4300 8 % % NN cord-015021-pol2qm74 4300 9 ) ) -RRB- cord-015021-pol2qm74 4300 10 . . . cord-015021-pol2qm74 4301 1 The the DT cord-015021-pol2qm74 4301 2 mean mean JJ cord-015021-pol2qm74 4301 3 increase increase NN cord-015021-pol2qm74 4301 4 was be VBD cord-015021-pol2qm74 4301 5 527 527 CD cord-015021-pol2qm74 4301 6 ng ng NN cord-015021-pol2qm74 4301 7 / / SYM cord-015021-pol2qm74 4301 8 ml ml NN cord-015021-pol2qm74 4301 9 ( ( -LRB- cord-015021-pol2qm74 4301 10 range range NN cord-015021-pol2qm74 4301 11 0 0 CD cord-015021-pol2qm74 4301 12 to to IN cord-015021-pol2qm74 4301 13 7362 7362 CD cord-015021-pol2qm74 4301 14 ng ng NN cord-015021-pol2qm74 4301 15 / / SYM cord-015021-pol2qm74 4301 16 ml ml NN cord-015021-pol2qm74 4301 17 ; ; : cord-015021-pol2qm74 4302 1 95 95 CD cord-015021-pol2qm74 4302 2 % % NN cord-015021-pol2qm74 4302 3 CI CI NNP cord-015021-pol2qm74 4302 4 was be VBD cord-015021-pol2qm74 4302 5 160 160 CD cord-015021-pol2qm74 4302 6 to to IN cord-015021-pol2qm74 4302 7 895 895 CD cord-015021-pol2qm74 4302 8 ng ng NN cord-015021-pol2qm74 4302 9 / / SYM cord-015021-pol2qm74 4302 10 ml ml NN cord-015021-pol2qm74 4302 11 ) ) -RRB- cord-015021-pol2qm74 4302 12 . . . cord-015021-pol2qm74 4303 1 Increase increase VB cord-015021-pol2qm74 4303 2 in in IN cord-015021-pol2qm74 4303 3 plasma plasma NN cord-015021-pol2qm74 4303 4 IgE IgE NNP cord-015021-pol2qm74 4303 5 was be VBD cord-015021-pol2qm74 4303 6 significantly significantly RB cord-015021-pol2qm74 4303 7 greater great JJR cord-015021-pol2qm74 4303 8 in in IN cord-015021-pol2qm74 4303 9 patients patient NNS cord-015021-pol2qm74 4303 10 with with IN cord-015021-pol2qm74 4303 11 sepsis sepsis NN cord-015021-pol2qm74 4303 12 syndrome syndrome NN cord-015021-pol2qm74 4303 13 ( ( -LRB- cord-015021-pol2qm74 4303 14 p=0.021 p=0.021 NNP cord-015021-pol2qm74 4303 15 ) ) -RRB- cord-015021-pol2qm74 4303 16 and and CC cord-015021-pol2qm74 4303 17 renal renal JJ cord-015021-pol2qm74 4303 18 failure failure NN cord-015021-pol2qm74 4303 19 ( ( -LRB- cord-015021-pol2qm74 4303 20 p<0.001 p<0.001 CD cord-015021-pol2qm74 4303 21 ) ) -RRB- cord-015021-pol2qm74 4303 22 . . . cord-015021-pol2qm74 4304 1 Although although IN cord-015021-pol2qm74 4304 2 mean mean NNP cord-015021-pol2qm74 4304 3 plasma plasma NNP cord-015021-pol2qm74 4304 4 IgE IgE NNP cord-015021-pol2qm74 4304 5 was be VBD cord-015021-pol2qm74 4304 6 higher high JJR cord-015021-pol2qm74 4304 7 with with IN cord-015021-pol2qm74 4304 8 ARDS ARDS NNP cord-015021-pol2qm74 4304 9 , , , cord-015021-pol2qm74 4304 10 pneumonia pneumonia NN cord-015021-pol2qm74 4304 11 , , , cord-015021-pol2qm74 4304 12 hepatic hepatic JJ cord-015021-pol2qm74 4304 13 dysfunction dysfunction NN cord-015021-pol2qm74 4304 14 , , , cord-015021-pol2qm74 4304 15 and and CC cord-015021-pol2qm74 4304 16 shock shock NN cord-015021-pol2qm74 4304 17 , , , cord-015021-pol2qm74 4304 18 these these DT cord-015021-pol2qm74 4304 19 differences difference NNS cord-015021-pol2qm74 4304 20 were be VBD cord-015021-pol2qm74 4304 21 not not RB cord-015021-pol2qm74 4304 22 significant significant JJ cord-015021-pol2qm74 4304 23 ( ( -LRB- cord-015021-pol2qm74 4304 24 p>0.05 p>0.05 NNP cord-015021-pol2qm74 4304 25 ) ) -RRB- cord-015021-pol2qm74 4304 26 . . . cord-015021-pol2qm74 4305 1 Plasma plasma NN cord-015021-pol2qm74 4305 2 IgE IgE NNP cord-015021-pol2qm74 4305 3 increase increase NN cord-015021-pol2qm74 4305 4 was be VBD cord-015021-pol2qm74 4305 5 not not RB cord-015021-pol2qm74 4305 6 related relate VBN cord-015021-pol2qm74 4305 7 to to IN cord-015021-pol2qm74 4305 8 severity severity NN cord-015021-pol2qm74 4305 9 of of IN cord-015021-pol2qm74 4305 10 injury injury NN cord-015021-pol2qm74 4305 11 by by IN cord-015021-pol2qm74 4305 12 ISS ISS NNP cord-015021-pol2qm74 4305 13 score score NN cord-015021-pol2qm74 4306 1 ( ( -LRB- cord-015021-pol2qm74 4306 2 p p NN cord-015021-pol2qm74 4306 3 = = SYM cord-015021-pol2qm74 4306 4 0.42 0.42 CD cord-015021-pol2qm74 4306 5 ) ) -RRB- cord-015021-pol2qm74 4306 6 . . . cord-015021-pol2qm74 4307 1 The the DT cord-015021-pol2qm74 4307 2 mean mean JJ cord-015021-pol2qm74 4307 3 day day NN cord-015021-pol2qm74 4307 4 to to IN cord-015021-pol2qm74 4307 5 highest high JJS cord-015021-pol2qm74 4307 6 IgE IgE NNP cord-015021-pol2qm74 4307 7 was be VBD cord-015021-pol2qm74 4307 8 9.1-+6.5 9.1-+6.5 CD cord-015021-pol2qm74 4307 9 . . . cord-015021-pol2qm74 4308 1 The the DT cord-015021-pol2qm74 4308 2 day day NN cord-015021-pol2qm74 4308 3 sepsis sepsis NN cord-015021-pol2qm74 4308 4 was be VBD cord-015021-pol2qm74 4308 5 first first RB cord-015021-pol2qm74 4308 6 observed observe VBN cord-015021-pol2qm74 4308 7 preceded precede VBD cord-015021-pol2qm74 4308 8 the the DT cord-015021-pol2qm74 4308 9 day day NN cord-015021-pol2qm74 4308 10 of of IN cord-015021-pol2qm74 4308 11 highest high JJS cord-015021-pol2qm74 4308 12 IgE IgE NNP cord-015021-pol2qm74 4308 13 by by IN cord-015021-pol2qm74 4308 14 4.2 4.2 CD cord-015021-pol2qm74 4308 15 + + SYM cord-015021-pol2qm74 4308 16 6.6 6.6 CD cord-015021-pol2qm74 4308 17 days day NNS cord-015021-pol2qm74 4308 18 . . . cord-015021-pol2qm74 4309 1 There there EX cord-015021-pol2qm74 4309 2 was be VBD cord-015021-pol2qm74 4309 3 a a DT cord-015021-pol2qm74 4309 4 significant significant JJ cord-015021-pol2qm74 4309 5 association association NN cord-015021-pol2qm74 4309 6 between between IN cord-015021-pol2qm74 4309 7 the the DT cord-015021-pol2qm74 4309 8 day day NN cord-015021-pol2qm74 4309 9 of of IN cord-015021-pol2qm74 4309 10 sepsis sepsis NN cord-015021-pol2qm74 4309 11 onset onset NN cord-015021-pol2qm74 4309 12 and and CC cord-015021-pol2qm74 4309 13 the the DT cord-015021-pol2qm74 4309 14 day day NN cord-015021-pol2qm74 4309 15 of of IN cord-015021-pol2qm74 4309 16 highest high JJS cord-015021-pol2qm74 4309 17 IgE IgE NNP cord-015021-pol2qm74 4309 18 ( ( -LRB- cord-015021-pol2qm74 4309 19 p=0.018 p=0.018 NNP cord-015021-pol2qm74 4309 20 ) ) -RRB- cord-015021-pol2qm74 4309 21 . . . cord-015021-pol2qm74 4310 1 Eight eight CD cord-015021-pol2qm74 4310 2 of of IN cord-015021-pol2qm74 4310 3 nine nine CD cord-015021-pol2qm74 4310 4 patients patient NNS cord-015021-pol2qm74 4310 5 with with IN cord-015021-pol2qm74 4310 6 sepsis sepsis NN cord-015021-pol2qm74 4310 7 syndrome syndrome NN cord-015021-pol2qm74 4310 8 had have VBD cord-015021-pol2qm74 4310 9 > > $ cord-015021-pol2qm74 4310 10 100 100 CD cord-015021-pol2qm74 4310 11 % % NN cord-015021-pol2qm74 4310 12 increase increase NN cord-015021-pol2qm74 4310 13 in in IN cord-015021-pol2qm74 4310 14 plasma plasma NN cord-015021-pol2qm74 4310 15 IgE IgE NNP cord-015021-pol2qm74 4310 16 from from IN cord-015021-pol2qm74 4310 17 admission admission NN cord-015021-pol2qm74 4310 18 . . . cord-015021-pol2qm74 4311 1 One one CD cord-015021-pol2qm74 4311 2 patient patient NN cord-015021-pol2qm74 4311 3 's 's POS cord-015021-pol2qm74 4311 4 IgE ige NN cord-015021-pol2qm74 4311 5 levels level NNS cord-015021-pol2qm74 4311 6 were be VBD cord-015021-pol2qm74 4311 7 normal normal JJ cord-015021-pol2qm74 4311 8 ( ( -LRB- cord-015021-pol2qm74 4311 9 20 20 CD cord-015021-pol2qm74 4311 10 - - SYM cord-015021-pol2qm74 4311 11 100 100 CD cord-015021-pol2qm74 4311 12 ng ng NN cord-015021-pol2qm74 4311 13 / / SYM cord-015021-pol2qm74 4311 14 ml ml NN cord-015021-pol2qm74 4311 15 ) ) -RRB- cord-015021-pol2qm74 4311 16 for for IN cord-015021-pol2qm74 4311 17 24 24 CD cord-015021-pol2qm74 4311 18 days day NNS cord-015021-pol2qm74 4311 19 and and CC cord-015021-pol2qm74 4311 20 then then RB cord-015021-pol2qm74 4311 21 increased increase VBD cord-015021-pol2qm74 4311 22 to to IN cord-015021-pol2qm74 4311 23 7300 7300 CD cord-015021-pol2qm74 4311 24 ng ng NN cord-015021-pol2qm74 4311 25 / / SYM cord-015021-pol2qm74 4311 26 ml ml NN cord-015021-pol2qm74 4311 27 over over IN cord-015021-pol2qm74 4311 28 the the DT cord-015021-pol2qm74 4311 29 next next JJ cord-015021-pol2qm74 4311 30 12 12 CD cord-015021-pol2qm74 4311 31 days day NNS cord-015021-pol2qm74 4311 32 , , , cord-015021-pol2qm74 4311 33 after after IN cord-015021-pol2qm74 4311 34 onset onset NN cord-015021-pol2qm74 4311 35 of of IN cord-015021-pol2qm74 4311 36 sepsis sepsis NN cord-015021-pol2qm74 4311 37 syndrome syndrome NN cord-015021-pol2qm74 4311 38 . . . cord-015021-pol2qm74 4312 1 Changes change NNS cord-015021-pol2qm74 4312 2 in in IN cord-015021-pol2qm74 4312 3 IgE ige NN cord-015021-pol2qm74 4312 4 plasma plasma NN cord-015021-pol2qm74 4312 5 levels level NNS cord-015021-pol2qm74 4312 6 may may MD cord-015021-pol2qm74 4312 7 reflect reflect VB cord-015021-pol2qm74 4312 8 the the DT cord-015021-pol2qm74 4312 9 action action NN cord-015021-pol2qm74 4312 10 of of IN cord-015021-pol2qm74 4312 11 cytokines cytokine NNS cord-015021-pol2qm74 4312 12 , , , cord-015021-pol2qm74 4312 13 such such JJ cord-015021-pol2qm74 4312 14 as as IN cord-015021-pol2qm74 4312 15 IL-4 IL-4 NNP cord-015021-pol2qm74 4312 16 , , , cord-015021-pol2qm74 4312 17 which which WDT cord-015021-pol2qm74 4312 18 concurrently concurrently RB cord-015021-pol2qm74 4312 19 regulate regulate VBP cord-015021-pol2qm74 4312 20 production production NN cord-015021-pol2qm74 4312 21 of of IN cord-015021-pol2qm74 4312 22 IgE IgE NNP cord-015021-pol2qm74 4312 23 and and CC cord-015021-pol2qm74 4312 24 IL-1 IL-1 NNP cord-015021-pol2qm74 4312 25 receptor receptor NN cord-015021-pol2qm74 4312 26 antagonist antagonist NN cord-015021-pol2qm74 4312 27 in in IN cord-015021-pol2qm74 4312 28 a a DT cord-015021-pol2qm74 4312 29 response response NN cord-015021-pol2qm74 4312 30 to to IN cord-015021-pol2qm74 4312 31 sepsis sepsis NN cord-015021-pol2qm74 4312 32 . . . cord-015021-pol2qm74 4313 1 Sepsis sepsis NN cord-015021-pol2qm74 4313 2 remains remain VBZ cord-015021-pol2qm74 4313 3 a a DT cord-015021-pol2qm74 4313 4 leading leading JJ cord-015021-pol2qm74 4313 5 cause cause NN cord-015021-pol2qm74 4313 6 of of IN cord-015021-pol2qm74 4313 7 late late JJ cord-015021-pol2qm74 4313 8 mortality mortality NN cord-015021-pol2qm74 4313 9 in in IN cord-015021-pol2qm74 4313 10 trauma trauma NN cord-015021-pol2qm74 4313 11 and and CC cord-015021-pol2qm74 4313 12 HS HS NNP cord-015021-pol2qm74 4313 13 . . . cord-015021-pol2qm74 4314 1 Although although IN cord-015021-pol2qm74 4314 2 HS HS NNP cord-015021-pol2qm74 4314 3 - - HYPH cord-015021-pol2qm74 4314 4 induced induce VBN cord-015021-pol2qm74 4314 5 bacterial bacterial JJ cord-015021-pol2qm74 4314 6 translocation translocation NN cord-015021-pol2qm74 4314 7 is be VBZ cord-015021-pol2qm74 4314 8 supposed suppose VBN cord-015021-pol2qm74 4314 9 to to TO cord-015021-pol2qm74 4314 10 be be VB cord-015021-pol2qm74 4314 11 the the DT cord-015021-pol2qm74 4314 12 major major JJ cord-015021-pol2qm74 4314 13 cause cause NN cord-015021-pol2qm74 4314 14 of of IN cord-015021-pol2qm74 4314 15 sepsis sepsis NN cord-015021-pol2qm74 4314 16 and and CC cord-015021-pol2qm74 4314 17 MOF MOF NNP cord-015021-pol2qm74 4314 18 , , , cord-015021-pol2qm74 4314 19 depression depression NN cord-015021-pol2qm74 4314 20 of of IN cord-015021-pol2qm74 4314 21 the the DT cord-015021-pol2qm74 4314 22 RES res NN cord-015021-pol2qm74 4314 23 increases increase VBZ cord-015021-pol2qm74 4314 24 susceptibility susceptibility NN cord-015021-pol2qm74 4314 25 to to IN cord-015021-pol2qm74 4314 26 infection infection NN cord-015021-pol2qm74 4314 27 after after IN cord-015021-pol2qm74 4314 28 injury injury NN cord-015021-pol2qm74 4314 29 . . . cord-015021-pol2qm74 4315 1 The the DT cord-015021-pol2qm74 4315 2 purposes purpose NNS cord-015021-pol2qm74 4315 3 of of IN cord-015021-pol2qm74 4315 4 this this DT cord-015021-pol2qm74 4315 5 study study NN cord-015021-pol2qm74 4315 6 were be VBD cord-015021-pol2qm74 4315 7 : : : cord-015021-pol2qm74 4315 8 a a LS cord-015021-pol2qm74 4315 9 ) ) -RRB- cord-015021-pol2qm74 4315 10 to to TO cord-015021-pol2qm74 4315 11 evaluate evaluate VB cord-015021-pol2qm74 4315 12 the the DT cord-015021-pol2qm74 4315 13 RES res NN cord-015021-pol2qm74 4315 14 in in IN cord-015021-pol2qm74 4315 15 the the DT cord-015021-pol2qm74 4315 16 lung lung NN cord-015021-pol2qm74 4315 17 , , , cord-015021-pol2qm74 4315 18 spleen spleen NN cord-015021-pol2qm74 4315 19 and and CC cord-015021-pol2qm74 4315 20 liver liver NN cord-015021-pol2qm74 4315 21 after after IN cord-015021-pol2qm74 4315 22 HS HS NNP cord-015021-pol2qm74 4315 23 and and CC cord-015021-pol2qm74 4315 24 subsequent subsequent JJ cord-015021-pol2qm74 4315 25 Hypertonic Hypertonic NNP cord-015021-pol2qm74 4315 26 Saline Saline NNP cord-015021-pol2qm74 4315 27 ( ( -LRB- cord-015021-pol2qm74 4315 28 HSL HSL NNP cord-015021-pol2qm74 4315 29 ) ) -RRB- cord-015021-pol2qm74 4315 30 treatment treatment NN cord-015021-pol2qm74 4315 31 , , , cord-015021-pol2qm74 4315 32 and and CC cord-015021-pol2qm74 4315 33 b b LS cord-015021-pol2qm74 4315 34 ) ) -RRB- cord-015021-pol2qm74 4315 35 to to TO cord-015021-pol2qm74 4315 36 document document VB cord-015021-pol2qm74 4315 37 the the DT cord-015021-pol2qm74 4315 38 patterns pattern NNS cord-015021-pol2qm74 4315 39 of of IN cord-015021-pol2qm74 4315 40 phagocytic phagocytic JJ cord-015021-pol2qm74 4315 41 activity activity NN cord-015021-pol2qm74 4315 42 in in IN cord-015021-pol2qm74 4315 43 these these DT cord-015021-pol2qm74 4315 44 organs organ NNS cord-015021-pol2qm74 4315 45 during during IN cord-015021-pol2qm74 4315 46 24 24 CD cord-015021-pol2qm74 4315 47 hrs hrs NN cord-015021-pol2qm74 4315 48 . . . cord-015021-pol2qm74 4316 1 Adult adult JJ cord-015021-pol2qm74 4316 2 male male JJ cord-015021-pol2qm74 4316 3 Wistar Wistar NNP cord-015021-pol2qm74 4316 4 rats rat NNS cord-015021-pol2qm74 4316 5 ( ( -LRB- cord-015021-pol2qm74 4316 6 250+_23 250+_23 CD cord-015021-pol2qm74 4316 7 gin gin NN cord-015021-pol2qm74 4316 8 ) ) -RRB- cord-015021-pol2qm74 4316 9 were be VBD cord-015021-pol2qm74 4316 10 submitted submit VBN cord-015021-pol2qm74 4316 11 to to IN cord-015021-pol2qm74 4316 12 HS HS NNP cord-015021-pol2qm74 4316 13 ( ( -LRB- cord-015021-pol2qm74 4316 14 SBP SBP NNP cord-015021-pol2qm74 4316 15 40 40 CD cord-015021-pol2qm74 4316 16 tort tort NN cord-015021-pol2qm74 4316 17 ) ) -RRB- cord-015021-pol2qm74 4316 18 and and CC cord-015021-pol2qm74 4316 19 after after IN cord-015021-pol2qm74 4316 20 t t NNP cord-015021-pol2qm74 4316 21 hr hr NNP cord-015021-pol2qm74 4316 22 ( ( -LRB- cord-015021-pol2qm74 4316 23 Shock shock NN cord-015021-pol2qm74 4316 24 I -PRON- PRP cord-015021-pol2qm74 4316 25 hr hr NN cord-015021-pol2qm74 4316 26 ) ) -RRB- cord-015021-pol2qm74 4316 27 and and CC cord-015021-pol2qm74 4316 28 24 24 CD cord-015021-pol2qm74 4316 29 hrs hrs NN cord-015021-pol2qm74 4316 30 ( ( -LRB- cord-015021-pol2qm74 4316 31 Shock shock NN cord-015021-pol2qm74 4316 32 24 24 CD cord-015021-pol2qm74 4316 33 hrs hrs NN cord-015021-pol2qm74 4316 34 ) ) -RRB- cord-015021-pol2qm74 4316 35 HSL hsl NN cord-015021-pol2qm74 4316 36 ( ( -LRB- cord-015021-pol2qm74 4316 37 NaC17.5 nac17.5 CD cord-015021-pol2qm74 4316 38 % % NN cord-015021-pol2qm74 4316 39 , , , cord-015021-pol2qm74 4316 40 3.5 3.5 CD cord-015021-pol2qm74 4316 41 ml ml NN cord-015021-pol2qm74 4316 42 / / SYM cord-015021-pol2qm74 4316 43 Kg Kg NNP cord-015021-pol2qm74 4316 44 ) ) -RRB- cord-015021-pol2qm74 4316 45 treatment treatment NN cord-015021-pol2qm74 4316 46 , , , cord-015021-pol2qm74 4316 47 1131 1131 CD cord-015021-pol2qm74 4316 48 E. E. NNP cord-015021-pol2qm74 4316 49 coli coli NNS cord-015021-pol2qm74 4316 50 ( ( -LRB- cord-015021-pol2qm74 4316 51 I i NN cord-015021-pol2qm74 4316 52 131 131 CD cord-015021-pol2qm74 4316 53 ) ) -RRB- cord-015021-pol2qm74 4316 54 was be VBD cord-015021-pol2qm74 4316 55 injected inject VBN cord-015021-pol2qm74 4316 56 into into IN cord-015021-pol2qm74 4316 57 the the DT cord-015021-pol2qm74 4316 58 portal portal JJ cord-015021-pol2qm74 4316 59 vein vein NN cord-015021-pol2qm74 4316 60 10 10 CD cord-015021-pol2qm74 4316 61 ~tCi ~tCi NFP cord-015021-pol2qm74 4316 62 ( ( -LRB- cord-015021-pol2qm74 4316 63 n_>12 n_>12 CD cord-015021-pol2qm74 4316 64 ) ) -RRB- cord-015021-pol2qm74 4316 65 . . . cord-015021-pol2qm74 4317 1 Twenty twenty CD cord-015021-pol2qm74 4317 2 minutes minute NNS cord-015021-pol2qm74 4317 3 later later RB cord-015021-pol2qm74 4317 4 , , , cord-015021-pol2qm74 4317 5 the the DT cord-015021-pol2qm74 4317 6 lungs lung NNS cord-015021-pol2qm74 4317 7 , , , cord-015021-pol2qm74 4317 8 spleen spleen NN cord-015021-pol2qm74 4317 9 and and CC cord-015021-pol2qm74 4317 10 liver liver NN cord-015021-pol2qm74 4317 11 were be VBD cord-015021-pol2qm74 4317 12 harvested harvest VBN cord-015021-pol2qm74 4317 13 and and CC cord-015021-pol2qm74 4317 14 scintilographic scintilographic JJ cord-015021-pol2qm74 4317 15 counts count NNS cord-015021-pol2qm74 4317 16 obtained obtain VBN cord-015021-pol2qm74 4317 17 . . . cord-015021-pol2qm74 4318 1 Data Data NNP cord-015021-pol2qm74 4318 2 is be VBZ cord-015021-pol2qm74 4318 3 depicted depict VBN cord-015021-pol2qm74 4318 4 as as IN cord-015021-pol2qm74 4318 5 mean_%+SEM mean_%+SEM NNP cord-015021-pol2qm74 4318 6 * * NFP cord-015021-pol2qm74 4318 7 p<0.05 p<0.05 NNP cord-015021-pol2qm74 4318 8 , , , cord-015021-pol2qm74 4318 9 ~ ~ NFP cord-015021-pol2qm74 4318 10 " " `` cord-015021-pol2qm74 4318 11 p<0.001 p<0.001 JJ cord-015021-pol2qm74 4318 12 and and CC cord-015021-pol2qm74 4318 13 statistical statistical JJ cord-015021-pol2qm74 4318 14 analysis analysis NN cord-015021-pol2qm74 4318 15 was be VBD cord-015021-pol2qm74 4318 16 performed perform VBN cord-015021-pol2qm74 4318 17 by by IN cord-015021-pol2qm74 4318 18 Analysis Analysis NNP cord-015021-pol2qm74 4318 19 of of IN cord-015021-pol2qm74 4318 20 Variance Variance NNP cord-015021-pol2qm74 4318 21 and and CC cord-015021-pol2qm74 4318 22 Wilcoxon Wilcoxon NNP cord-015021-pol2qm74 4318 23 tests test NNS cord-015021-pol2qm74 4318 24 . . . cord-015021-pol2qm74 4319 1 One one CD cord-015021-pol2qm74 4319 2 hr hr NN cord-015021-pol2qm74 4319 3 after after IN cord-015021-pol2qm74 4319 4 treatment treatment NN cord-015021-pol2qm74 4319 5 , , , cord-015021-pol2qm74 4319 6 lung lung NN cord-015021-pol2qm74 4319 7 1131 1131 CD cord-015021-pol2qm74 4319 8 uptake uptake NN cord-015021-pol2qm74 4319 9 was be VBD cord-015021-pol2qm74 4319 10 increased increase VBN cord-015021-pol2qm74 4319 11 and and CC cord-015021-pol2qm74 4319 12 liver liver NN cord-015021-pol2qm74 4319 13 and and CC cord-015021-pol2qm74 4319 14 spleen spleen NN cord-015021-pol2qm74 4319 15 1131 1131 CD cord-015021-pol2qm74 4320 1 uptake uptake NN cord-015021-pol2qm74 4320 2 were be VBD cord-015021-pol2qm74 4320 3 reduced reduce VBN cord-015021-pol2qm74 4320 4 compared compare VBN cord-015021-pol2qm74 4320 5 to to IN cord-015021-pol2qm74 4320 6 sham sham NN cord-015021-pol2qm74 4320 7 . . . cord-015021-pol2qm74 4321 1 Twenty twenty CD cord-015021-pol2qm74 4321 2 four four CD cord-015021-pol2qm74 4321 3 hrs hrs NN cord-015021-pol2qm74 4321 4 after after IN cord-015021-pol2qm74 4321 5 treatment treatment NN cord-015021-pol2qm74 4321 6 , , , cord-015021-pol2qm74 4321 7 all all DT cord-015021-pol2qm74 4321 8 organs organ NNS cord-015021-pol2qm74 4321 9 , , , cord-015021-pol2qm74 4321 10 except except IN cord-015021-pol2qm74 4321 11 lung lung NN cord-015021-pol2qm74 4321 12 uptake uptake NN cord-015021-pol2qm74 4321 13 , , , cord-015021-pol2qm74 4321 14 returned return VBD cord-015021-pol2qm74 4321 15 to to IN cord-015021-pol2qm74 4321 16 normal normal JJ cord-015021-pol2qm74 4321 17 values value NNS cord-015021-pol2qm74 4321 18 . . . cord-015021-pol2qm74 4322 1 Radioautographic radioautographic JJ cord-015021-pol2qm74 4322 2 histological histological JJ cord-015021-pol2qm74 4322 3 analysis analysis NN cord-015021-pol2qm74 4322 4 revealed reveal VBD cord-015021-pol2qm74 4322 5 radiolabeled radiolabele VBN cord-015021-pol2qm74 4322 6 particles particle NNS cord-015021-pol2qm74 4322 7 inside inside IN cord-015021-pol2qm74 4322 8 phagocytic phagocytic JJ cord-015021-pol2qm74 4322 9 cells cell NNS cord-015021-pol2qm74 4322 10 of of IN cord-015021-pol2qm74 4322 11 all all DT cord-015021-pol2qm74 4322 12 organs organ NNS cord-015021-pol2qm74 4322 13 . . . cord-015021-pol2qm74 4323 1 We -PRON- PRP cord-015021-pol2qm74 4323 2 conclude conclude VBP cord-015021-pol2qm74 4323 3 that that IN cord-015021-pol2qm74 4323 4 pulmonary pulmonary JJ cord-015021-pol2qm74 4323 5 phagocytic phagocytic JJ cord-015021-pol2qm74 4323 6 activity activity NN cord-015021-pol2qm74 4323 7 increases increase NNS cord-015021-pol2qm74 4323 8 after after IN cord-015021-pol2qm74 4323 9 1 1 CD cord-015021-pol2qm74 4323 10 hr hr NN cord-015021-pol2qm74 4323 11 of of IN cord-015021-pol2qm74 4323 12 HS HS NNP cord-015021-pol2qm74 4323 13 HSL HSL NNP cord-015021-pol2qm74 4323 14 reatment reatment NN cord-015021-pol2qm74 4323 15 , , , cord-015021-pol2qm74 4323 16 diminishing diminish VBG cord-015021-pol2qm74 4323 17 by by IN cord-015021-pol2qm74 4323 18 24 24 CD cord-015021-pol2qm74 4323 19 hrs hrs NN cord-015021-pol2qm74 4323 20 although although IN cord-015021-pol2qm74 4323 21 still still RB cord-015021-pol2qm74 4323 22 above above IN cord-015021-pol2qm74 4323 23 normal normal JJ cord-015021-pol2qm74 4323 24 values value NNS cord-015021-pol2qm74 4323 25 . . . cord-015021-pol2qm74 4324 1 In in IN cord-015021-pol2qm74 4324 2 contrast contrast NN cord-015021-pol2qm74 4324 3 , , , cord-015021-pol2qm74 4324 4 RES res NN cord-015021-pol2qm74 4324 5 suppression suppression NN cord-015021-pol2qm74 4324 6 occurs occur VBZ cord-015021-pol2qm74 4324 7 in in IN cord-015021-pol2qm74 4324 8 liver liver NN cord-015021-pol2qm74 4324 9 and and CC cord-015021-pol2qm74 4324 10 spleen spleen NNS cord-015021-pol2qm74 4324 11 after after IN cord-015021-pol2qm74 4324 12 1 1 CD cord-015021-pol2qm74 4324 13 hr hr NN cord-015021-pol2qm74 4324 14 HS HS NNP cord-015021-pol2qm74 4324 15 HSL HSL NNP cord-015021-pol2qm74 4324 16 treatment treatment NN cord-015021-pol2qm74 4324 17 , , , cord-015021-pol2qm74 4324 18 returning return VBG cord-015021-pol2qm74 4324 19 to to IN cord-015021-pol2qm74 4324 20 normal normal JJ cord-015021-pol2qm74 4324 21 values value NNS cord-015021-pol2qm74 4324 22 by by IN cord-015021-pol2qm74 4324 23 24 24 CD cord-015021-pol2qm74 4324 24 hrs hrs NN cord-015021-pol2qm74 4324 25 . . . cord-015021-pol2qm74 4325 1 These these DT cord-015021-pol2qm74 4325 2 results result NNS cord-015021-pol2qm74 4325 3 may may MD cord-015021-pol2qm74 4325 4 explain explain VB cord-015021-pol2qm74 4325 5 lung lung NN cord-015021-pol2qm74 4325 6 complications complication NNS cord-015021-pol2qm74 4325 7 and and CC cord-015021-pol2qm74 4325 8 immunosuppression immunosuppression NN cord-015021-pol2qm74 4325 9 after after IN cord-015021-pol2qm74 4325 10 trauma trauma NN cord-015021-pol2qm74 4325 11 . . . cord-015021-pol2qm74 4326 1 Infusion infusion NN cord-015021-pol2qm74 4326 2 of of IN cord-015021-pol2qm74 4326 3 endotoxin endotoxin NN cord-015021-pol2qm74 4326 4 as as RB cord-015021-pol2qm74 4326 5 well well RB cord-015021-pol2qm74 4326 6 as as IN cord-015021-pol2qm74 4326 7 major major JJ cord-015021-pol2qm74 4326 8 surgery surgery NN cord-015021-pol2qm74 4326 9 is be VBZ cord-015021-pol2qm74 4326 10 followed follow VBN cord-015021-pol2qm74 4326 11 by by IN cord-015021-pol2qm74 4326 12 lymphopenia lymphopenia NNP cord-015021-pol2qm74 4326 13 in in IN cord-015021-pol2qm74 4326 14 peripheral peripheral JJ cord-015021-pol2qm74 4326 15 blood blood NN cord-015021-pol2qm74 4326 16 . . . cord-015021-pol2qm74 4327 1 The the DT cord-015021-pol2qm74 4327 2 purpose purpose NN cord-015021-pol2qm74 4327 3 of of IN cord-015021-pol2qm74 4327 4 this this DT cord-015021-pol2qm74 4327 5 study study NN cord-015021-pol2qm74 4327 6 was be VBD cord-015021-pol2qm74 4327 7 to to TO cord-015021-pol2qm74 4327 8 investigate investigate VB cord-015021-pol2qm74 4327 9 to to TO cord-015021-pol2qm74 4327 10 which which WDT cord-015021-pol2qm74 4327 11 tissues tissue VBZ cord-015021-pol2qm74 4327 12 the the DT cord-015021-pol2qm74 4327 13 lymphocytes lymphocyte NNS cord-015021-pol2qm74 4327 14 are be VBP cord-015021-pol2qm74 4327 15 redistributed redistribute VBN cord-015021-pol2qm74 4327 16 in in IN cord-015021-pol2qm74 4327 17 response response NN cord-015021-pol2qm74 4327 18 to to IN cord-015021-pol2qm74 4327 19 endotoxaemia endotoxaemia NN cord-015021-pol2qm74 4327 20 and and CC cord-015021-pol2qm74 4327 21 major major JJ cord-015021-pol2qm74 4327 22 surgery surgery NN cord-015021-pol2qm74 4327 23 . . . cord-015021-pol2qm74 4328 1 In in IN cord-015021-pol2qm74 4328 2 addition addition NN cord-015021-pol2qm74 4328 3 changes change NNS cord-015021-pol2qm74 4328 4 in in IN cord-015021-pol2qm74 4328 5 lymphocyte lymphocyte NN cord-015021-pol2qm74 4328 6 subpopulations subpopulation NNS cord-015021-pol2qm74 4328 7 and and CC cord-015021-pol2qm74 4328 8 expression expression NN cord-015021-pol2qm74 4328 9 of of IN cord-015021-pol2qm74 4328 10 MECII MECII NNP cord-015021-pol2qm74 4328 11 was be VBD cord-015021-pol2qm74 4328 12 measured measure VBN cord-015021-pol2qm74 4328 13 . . . cord-015021-pol2qm74 4329 1 Lymphocytes lymphocyte NNS cord-015021-pol2qm74 4329 2 were be VBD cord-015021-pol2qm74 4329 3 isolated isolate VBN cord-015021-pol2qm74 4329 4 from from IN cord-015021-pol2qm74 4329 5 peripheral peripheral JJ cord-015021-pol2qm74 4329 6 blood blood NN cord-015021-pol2qm74 4329 7 of of IN cord-015021-pol2qm74 4329 8 30 30 CD cord-015021-pol2qm74 4329 9 rabbits rabbit NNS cord-015021-pol2qm74 4329 10 , , , cord-015021-pol2qm74 4329 11 labelled label VBN cord-015021-pol2qm74 4329 12 with with IN cord-015021-pol2qm74 4329 13 111Indium 111indium CD cord-015021-pol2qm74 4329 14 - - HYPH cord-015021-pol2qm74 4329 15 tropolene tropolene NN cord-015021-pol2qm74 4329 16 and and CC cord-015021-pol2qm74 4329 17 reinjected reinjecte VBD cord-015021-pol2qm74 4329 18 intravenously intravenously RB cord-015021-pol2qm74 4329 19 into into IN cord-015021-pol2qm74 4329 20 the the DT cord-015021-pol2qm74 4329 21 rabbits rabbit NNS cord-015021-pol2qm74 4329 22 , , , cord-015021-pol2qm74 4329 23 i0 i0 NN cord-015021-pol2qm74 4329 24 rabbits rabbit NNS cord-015021-pol2qm74 4329 25 received receive VBD cord-015021-pol2qm74 4329 26 an an DT cord-015021-pol2qm74 4329 27 infusion infusion NN cord-015021-pol2qm74 4329 28 of of IN cord-015021-pol2qm74 4329 29 Escherichia Escherichia NNP cord-015021-pol2qm74 4329 30 coli coli NNS cord-015021-pol2qm74 4329 31 endotoxin endotoxin NN cord-015021-pol2qm74 4329 32 2 2 CD cord-015021-pol2qm74 4330 1 ~g ~g NNP cord-015021-pol2qm74 4330 2 / / SYM cord-015021-pol2qm74 4330 3 kg kg NNS cord-015021-pol2qm74 4330 4 , , , cord-015021-pol2qm74 4330 5 while while IN cord-015021-pol2qm74 4330 6 i0 i0 NN cord-015021-pol2qm74 4330 7 rabbits rabbit NNS cord-015021-pol2qm74 4330 8 were be VBD cord-015021-pol2qm74 4330 9 subjected subject VBN cord-015021-pol2qm74 4330 10 to to IN cord-015021-pol2qm74 4330 11 a a DT cord-015021-pol2qm74 4330 12 major major JJ cord-015021-pol2qm74 4330 13 sham sham JJ cord-015021-pol2qm74 4330 14 operation operation NN cord-015021-pol2qm74 4330 15 and and CC cord-015021-pol2qm74 4330 16 i0 i0 NN cord-015021-pol2qm74 4330 17 rabbits rabbit NNS cord-015021-pol2qm74 4330 18 served serve VBD cord-015021-pol2qm74 4330 19 as as IN cord-015021-pol2qm74 4330 20 a a DT cord-015021-pol2qm74 4330 21 control control NN cord-015021-pol2qm74 4330 22 group group NN cord-015021-pol2qm74 4330 23 . . . cord-015021-pol2qm74 4331 1 The the DT cord-015021-pol2qm74 4331 2 redistribution redistribution NN cord-015021-pol2qm74 4331 3 of of IN cord-015021-pol2qm74 4331 4 lymphocytes lymphocyte NNS cord-015021-pol2qm74 4331 5 were be VBD cord-015021-pol2qm74 4331 6 imaged image VBN cord-015021-pol2qm74 4331 7 with with IN cord-015021-pol2qm74 4331 8 af af NNP cord-015021-pol2qm74 4331 9 gamma gamma NN cord-015021-pol2qm74 4331 10 camera camera NN cord-015021-pol2qm74 4331 11 , , , cord-015021-pol2qm74 4331 12 and and CC cord-015021-pol2qm74 4331 13 calculated calculate VBN cord-015021-pol2qm74 4331 14 with with IN cord-015021-pol2qm74 4331 15 an an DT cord-015021-pol2qm74 4331 16 interfaces interface NNS cord-015021-pol2qm74 4331 17 computer computer NN cord-015021-pol2qm74 4331 18 before before RB cord-015021-pol2qm74 4331 19 , , , cord-015021-pol2qm74 4331 20 and and CC cord-015021-pol2qm74 4331 21 2 2 CD cord-015021-pol2qm74 4331 22 , , , cord-015021-pol2qm74 4331 23 4 4 CD cord-015021-pol2qm74 4331 24 and and CC cord-015021-pol2qm74 4331 25 6 6 CD cord-015021-pol2qm74 4331 26 hours hour NNS cord-015021-pol2qm74 4331 27 after after IN cord-015021-pol2qm74 4331 28 major major JJ cord-015021-pol2qm74 4331 29 surgery surgery NN cord-015021-pol2qm74 4331 30 or or CC cord-015021-pol2qm74 4331 31 infusion infusion NN cord-015021-pol2qm74 4331 32 of of IN cord-015021-pol2qm74 4331 33 endotoxin endotoxin NN cord-015021-pol2qm74 4331 34 or or CC cord-015021-pol2qm74 4331 35 saline saline NN cord-015021-pol2qm74 4331 36 . . . cord-015021-pol2qm74 4332 1 Interleukin Interleukin NNP cord-015021-pol2qm74 4332 2 - - HYPH cord-015021-pol2qm74 4332 3 l~ l~ XX cord-015021-pol2qm74 4332 4 and and CC cord-015021-pol2qm74 4332 5 serum serum NN cord-015021-pol2qm74 4332 6 cortisol cortisol NN cord-015021-pol2qm74 4332 7 were be VBD cord-015021-pol2qm74 4332 8 measured measure VBN cord-015021-pol2qm74 4332 9 . . . cord-015021-pol2qm74 4333 1 In in IN cord-015021-pol2qm74 4333 2 addition addition NN cord-015021-pol2qm74 4333 3 we -PRON- PRP cord-015021-pol2qm74 4333 4 followed follow VBD cord-015021-pol2qm74 4333 5 CD2 CD2 NNP cord-015021-pol2qm74 4333 6 , , , cord-015021-pol2qm74 4333 7 CD3 CD3 NNP cord-015021-pol2qm74 4333 8 , , , cord-015021-pol2qm74 4333 9 CDlla CDlla NNP cord-015021-pol2qm74 4333 10 / / SYM cord-015021-pol2qm74 4333 11 b b NN cord-015021-pol2qm74 4333 12 , , , cord-015021-pol2qm74 4333 13 CDIS CDIS NNP cord-015021-pol2qm74 4333 14 , , , cord-015021-pol2qm74 4333 15 CD20 CD20 NNP cord-015021-pol2qm74 4333 16 , , , cord-015021-pol2qm74 4333 17 CD44 CD44 NNP cord-015021-pol2qm74 4333 18 , , , cord-015021-pol2qm74 4333 19 MHCII MHCII NNP cord-015021-pol2qm74 4333 20 and and CC cord-015021-pol2qm74 4333 21 CD4 CD4 NNP cord-015021-pol2qm74 4333 22 / / SYM cord-015021-pol2qm74 4333 23 CD8 CD8 NNP cord-015021-pol2qm74 4333 24 ratio ratio NN cord-015021-pol2qm74 4333 25 . . . cord-015021-pol2qm74 4334 1 Following follow VBG cord-015021-pol2qm74 4334 2 endotoxaemia endotoxaemia NN cord-015021-pol2qm74 4334 3 Interleukin Interleukin NNP cord-015021-pol2qm74 4334 4 - - HYPH cord-015021-pol2qm74 4334 5 lf~ lf~ NN cord-015021-pol2qm74 4334 6 increased increase VBD cord-015021-pol2qm74 4334 7 significantly significantly RB cord-015021-pol2qm74 4334 8 , , , cord-015021-pol2qm74 4334 9 following follow VBG cord-015021-pol2qm74 4334 10 endotoxaemia endotoxaemia NN cord-015021-pol2qm74 4334 11 as as RB cord-015021-pol2qm74 4334 12 well well RB cord-015021-pol2qm74 4334 13 as as IN cord-015021-pol2qm74 4334 14 major major JJ cord-015021-pol2qm74 4334 15 surgery surgery NN cord-015021-pol2qm74 4334 16 serum serum NN cord-015021-pol2qm74 4334 17 cortisol cortisol NN cord-015021-pol2qm74 4334 18 increased increase VBD cord-015021-pol2qm74 4334 19 significantly significantly RB cord-015021-pol2qm74 4334 20 . . . cord-015021-pol2qm74 4335 1 Following follow VBG cord-015021-pol2qm74 4335 2 major major JJ cord-015021-pol2qm74 4335 3 surgery surgery NN cord-015021-pol2qm74 4335 4 as as RB cord-015021-pol2qm74 4335 5 well well RB cord-015021-pol2qm74 4335 6 as as IN cord-015021-pol2qm74 4335 7 endotoxaemia endotoxaemia NN cord-015021-pol2qm74 4335 8 there there EX cord-015021-pol2qm74 4335 9 was be VBD cord-015021-pol2qm74 4335 10 significant significant JJ cord-015021-pol2qm74 4335 11 lomphocytepenia lomphocytepenia NN cord-015021-pol2qm74 4335 12 in in IN cord-015021-pol2qm74 4335 13 peripheral peripheral JJ cord-015021-pol2qm74 4335 14 blood blood NN cord-015021-pol2qm74 4335 15 with with IN cord-015021-pol2qm74 4335 16 a a DT cord-015021-pol2qm74 4335 17 decreased decreased JJ cord-015021-pol2qm74 4335 18 CD4 CD4 NNP cord-015021-pol2qm74 4335 19 / / SYM cord-015021-pol2qm74 4335 20 CD8 CD8 NNP cord-015021-pol2qm74 4335 21 ratio ratio NN cord-015021-pol2qm74 4335 22 while while IN cord-015021-pol2qm74 4335 23 the the DT cord-015021-pol2qm74 4335 24 CD3 CD3 NNP cord-015021-pol2qm74 4335 25 positive positive JJ cord-015021-pol2qm74 4335 26 subpopulation subpopulation NN cord-015021-pol2qm74 4335 27 increased increase VBD cord-015021-pol2qm74 4335 28 . . . cord-015021-pol2qm74 4336 1 In in IN cord-015021-pol2qm74 4336 2 addition addition NN cord-015021-pol2qm74 4336 3 there there EX cord-015021-pol2qm74 4336 4 was be VBD cord-015021-pol2qm74 4336 5 a a DT cord-015021-pol2qm74 4336 6 decrease decrease NN cord-015021-pol2qm74 4336 7 in in IN cord-015021-pol2qm74 4336 8 the the DT cord-015021-pol2qm74 4336 9 expression expression NN cord-015021-pol2qm74 4336 10 of of IN cord-015021-pol2qm74 4336 11 MHCII MHCII NNP cord-015021-pol2qm74 4336 12 on on IN cord-015021-pol2qm74 4336 13 the the DT cord-015021-pol2qm74 4336 14 lymphocytes lymphocyte NNS cord-015021-pol2qm74 4336 15 peripheral peripheral JJ cord-015021-pol2qm74 4336 16 blood blood NN cord-015021-pol2qm74 4336 17 . . . cord-015021-pol2qm74 4337 1 The the DT cord-015021-pol2qm74 4337 2 radioactivity radioactivity NN cord-015021-pol2qm74 4337 3 of of IN cord-015021-pol2qm74 4337 4 the the DT cord-015021-pol2qm74 4337 5 lymphatic lymphatic JJ cord-015021-pol2qm74 4337 6 tissue tissue NN cord-015021-pol2qm74 4337 7 in in IN cord-015021-pol2qm74 4337 8 and and CC cord-015021-pol2qm74 4337 9 around around IN cord-015021-pol2qm74 4337 10 the the DT cord-015021-pol2qm74 4337 11 intestine intestine NN cord-015021-pol2qm74 4337 12 increased increase VBD cord-015021-pol2qm74 4337 13 to to IN cord-015021-pol2qm74 4337 14 129 129 CD cord-015021-pol2qm74 4337 15 % % NN cord-015021-pol2qm74 4337 16 of of IN cord-015021-pol2qm74 4337 17 initial initial JJ cord-015021-pol2qm74 4337 18 values value NNS cord-015021-pol2qm74 4337 19 following follow VBG cord-015021-pol2qm74 4337 20 endotoxaemia endotoxaemia NN cord-015021-pol2qm74 4337 21 and and CC cord-015021-pol2qm74 4337 22 to to IN cord-015021-pol2qm74 4337 23 125 125 CD cord-015021-pol2qm74 4337 24 % % NN cord-015021-pol2qm74 4337 25 following follow VBG cord-015021-pol2qm74 4337 26 major major JJ cord-015021-pol2qm74 4337 27 surgery surgery NN cord-015021-pol2qm74 4337 28 . . . cord-015021-pol2qm74 4338 1 The the DT cord-015021-pol2qm74 4338 2 results result NNS cord-015021-pol2qm74 4338 3 indicate indicate VBP cord-015021-pol2qm74 4338 4 that that IN cord-015021-pol2qm74 4338 5 endotoxaemia endotoxaemia NN cord-015021-pol2qm74 4338 6 as as RB cord-015021-pol2qm74 4338 7 well well RB cord-015021-pol2qm74 4338 8 as as IN cord-015021-pol2qm74 4338 9 major major JJ cord-015021-pol2qm74 4338 10 surgery surgery NN cord-015021-pol2qm74 4338 11 induces induce VBZ cord-015021-pol2qm74 4338 12 redistribution redistribution NN cord-015021-pol2qm74 4338 13 of of IN cord-015021-pol2qm74 4338 14 lymphocytes lymphocyte NNS cord-015021-pol2qm74 4338 15 from from IN cord-015021-pol2qm74 4338 16 peripheral peripheral JJ cord-015021-pol2qm74 4338 17 blood blood NN cord-015021-pol2qm74 4338 18 to to IN cord-015021-pol2qm74 4338 19 lymphatic lymphatic JJ cord-015021-pol2qm74 4338 20 tissue tissue NN cord-015021-pol2qm74 4338 21 . . . cord-015021-pol2qm74 4339 1 Among among IN cord-015021-pol2qm74 4339 2 the the DT cord-015021-pol2qm74 4339 3 lymphocytes lymphocyte NNS cord-015021-pol2qm74 4339 4 staying stay VBG cord-015021-pol2qm74 4339 5 in in IN cord-015021-pol2qm74 4339 6 peripheral peripheral JJ cord-015021-pol2qm74 4339 7 blood blood NN cord-015021-pol2qm74 4339 8 there there EX cord-015021-pol2qm74 4339 9 was be VBD cord-015021-pol2qm74 4339 10 a a DT cord-015021-pol2qm74 4339 11 decreased decreased JJ cord-015021-pol2qm74 4339 12 expression expression NN cord-015021-pol2qm74 4339 13 of of IN cord-015021-pol2qm74 4339 14 MHCII MHCII NNP cord-015021-pol2qm74 4339 15 and and CC cord-015021-pol2qm74 4339 16 a a DT cord-015021-pol2qm74 4339 17 relative relative JJ cord-015021-pol2qm74 4339 18 decrease decrease NN cord-015021-pol2qm74 4339 19 in in IN cord-015021-pol2qm74 4339 20 CD4 CD4 NNP cord-015021-pol2qm74 4339 21 cells cell NNS cord-015021-pol2qm74 4339 22 compared compare VBN cord-015021-pol2qm74 4339 23 to to IN cord-015021-pol2qm74 4339 24 CD8 CD8 NNP cord-015021-pol2qm74 4339 25 positive positive JJ cord-015021-pol2qm74 4339 26 lymphocytes lymphocyte NNS cord-015021-pol2qm74 4339 27 . . . cord-015021-pol2qm74 4340 1 In in IN cord-015021-pol2qm74 4340 2 order order NN cord-015021-pol2qm74 4340 3 to to TO cord-015021-pol2qm74 4340 4 analyze analyze VB cord-015021-pol2qm74 4340 5 the the DT cord-015021-pol2qm74 4340 6 effects effect NNS cord-015021-pol2qm74 4340 7 of of IN cord-015021-pol2qm74 4340 8 immune immune JJ cord-015021-pol2qm74 4340 9 suppressive suppressive JJ cord-015021-pol2qm74 4340 10 substances substance NNS cord-015021-pol2qm74 4340 11 on on IN cord-015021-pol2qm74 4340 12 expression expression NN cord-015021-pol2qm74 4340 13 of of IN cord-015021-pol2qm74 4340 14 mRNA mrna NN cord-015021-pol2qm74 4340 15 of of IN cord-015021-pol2qm74 4340 16 interleukin-2(IL-2 interleukin-2(IL-2 NNP cord-015021-pol2qm74 4340 17 ) ) -RRB- cord-015021-pol2qm74 4340 18 and and CC cord-015021-pol2qm74 4340 19 interleukin-2 interleukin-2 IN cord-015021-pol2qm74 4340 20 reeeptor(IL-2R reeeptor(IL-2R NNP cord-015021-pol2qm74 4340 21 ) ) -RRB- cord-015021-pol2qm74 4340 22 , , , cord-015021-pol2qm74 4340 23 this this DT cord-015021-pol2qm74 4340 24 study study NN cord-015021-pol2qm74 4340 25 was be VBD cord-015021-pol2qm74 4340 26 carried carry VBN cord-015021-pol2qm74 4340 27 out out RP cord-015021-pol2qm74 4340 28 . . . cord-015021-pol2qm74 4341 1 Twenty twenty CD cord-015021-pol2qm74 4341 2 male male JJ cord-015021-pol2qm74 4341 3 rabbits rabbit NNS cord-015021-pol2qm74 4341 4 with with IN cord-015021-pol2qm74 4341 5 comminuted comminuted JJ cord-015021-pol2qm74 4341 6 fracture fracture NN cord-015021-pol2qm74 4341 7 were be VBD cord-015021-pol2qm74 4341 8 used use VBN cord-015021-pol2qm74 4341 9 in in IN cord-015021-pol2qm74 4341 10 the the DT cord-015021-pol2qm74 4341 11 study study NN cord-015021-pol2qm74 4341 12 . . . cord-015021-pol2qm74 4342 1 Ten ten CD cord-015021-pol2qm74 4342 2 ml ml NN cord-015021-pol2qm74 4342 3 blood blood NN cord-015021-pol2qm74 4342 4 were be VBD cord-015021-pol2qm74 4342 5 taken take VBN cord-015021-pol2qm74 4342 6 at at IN cord-015021-pol2qm74 4342 7 0 0 CD cord-015021-pol2qm74 4342 8 , , , cord-015021-pol2qm74 4342 9 i i PRP cord-015021-pol2qm74 4342 10 , , , cord-015021-pol2qm74 4342 11 2 2 CD cord-015021-pol2qm74 4342 12 , , , cord-015021-pol2qm74 4342 13 4 4 CD cord-015021-pol2qm74 4342 14 , , , cord-015021-pol2qm74 4342 15 6 6 CD cord-015021-pol2qm74 4342 16 days day NNS cord-015021-pol2qm74 4342 17 after after IN cord-015021-pol2qm74 4342 18 injury injury NN cord-015021-pol2qm74 4342 19 . . . cord-015021-pol2qm74 4343 1 The the DT cord-015021-pol2qm74 4343 2 sera sera NNP cord-015021-pol2qm74 4343 3 were be VBD cord-015021-pol2qm74 4343 4 tested test VBN cord-015021-pol2qm74 4343 5 for for IN cord-015021-pol2qm74 4343 6 the the DT cord-015021-pol2qm74 4343 7 effects effect NNS cord-015021-pol2qm74 4343 8 on on IN cord-015021-pol2qm74 4343 9 lymphocyte lymphocyte NN cord-015021-pol2qm74 4343 10 blastogenesis blastogenesis NN cord-015021-pol2qm74 4343 11 and and CC cord-015021-pol2qm74 4343 12 induction induction NN cord-015021-pol2qm74 4343 13 of of IN cord-015021-pol2qm74 4343 14 IL-2 il-2 NN cord-015021-pol2qm74 4343 15 stimulated stimulate VBN cord-015021-pol2qm74 4343 16 by by IN cord-015021-pol2qm74 4343 17 concanavalin concanavalin NNP cord-015021-pol2qm74 4343 18 A(Con A(Con NNP cord-015021-pol2qm74 4343 19 A A NNP cord-015021-pol2qm74 4343 20 ) ) -RRB- cord-015021-pol2qm74 4343 21 : : : cord-015021-pol2qm74 4344 1 The the DT cord-015021-pol2qm74 4344 2 sera sera NNP cord-015021-pol2qm74 4344 3 from from IN cord-015021-pol2qm74 4344 4 the the DT cord-015021-pol2qm74 4344 5 rabbits rabbit NNS cord-015021-pol2qm74 4345 1 2 2 CD cord-015021-pol2qm74 4345 2 days day NNS cord-015021-pol2qm74 4345 3 after after IN cord-015021-pol2qm74 4345 4 injury injury NN cord-015021-pol2qm74 4345 5 were be VBD cord-015021-pol2qm74 4345 6 analyzed analyze VBN cord-015021-pol2qm74 4345 7 with with IN cord-015021-pol2qm74 4345 8 SDS SDS NNP cord-015021-pol2qm74 4345 9 - - HYPH cord-015021-pol2qm74 4345 10 PAGE page NN cord-015021-pol2qm74 4345 11 gel gel NN cord-015021-pol2qm74 4345 12 eleetrophoresis eleetrophoresis NN cord-015021-pol2qm74 4345 13 , , , cord-015021-pol2qm74 4345 14 and and CC cord-015021-pol2qm74 4345 15 divided divide VBD cord-015021-pol2qm74 4345 16 into into IN cord-015021-pol2qm74 4345 17 three three CD cord-015021-pol2qm74 4345 18 groups group NNS cord-015021-pol2qm74 4345 19 by by IN cord-015021-pol2qm74 4345 20 ultrafiltration ultrafiltration NN cord-015021-pol2qm74 4345 21 ( ( -LRB- cord-015021-pol2qm74 4345 22 UFPI UFPI NNP cord-015021-pol2qm74 4345 23 TTK TTK NNP cord-015021-pol2qm74 4345 24 , , , cord-015021-pol2qm74 4345 25 30KD 30kd CD cord-015021-pol2qm74 4345 26 , , , cord-015021-pol2qm74 4345 27 Milipore Milipore NNP cord-015021-pol2qm74 4345 28 ; ; : cord-015021-pol2qm74 4345 29 Centricon-10,10KD centricon-10,10kd PRP$ cord-015021-pol2qm74 4345 30 , , , cord-015021-pol2qm74 4345 31 Amicon Amicon NNP cord-015021-pol2qm74 4345 32 ) ) -RRB- cord-015021-pol2qm74 4345 33 , , , cord-015021-pol2qm74 4345 34 that that WDT cord-015021-pol2qm74 4345 35 are be VBP cord-015021-pol2qm74 4345 36 less less JJR cord-015021-pol2qm74 4345 37 than than IN cord-015021-pol2qm74 4345 38 10KD 10kd CD cord-015021-pol2qm74 4345 39 , , , cord-015021-pol2qm74 4345 40 between between IN cord-015021-pol2qm74 4345 41 i0 i0 NN cord-015021-pol2qm74 4345 42 and and CC cord-015021-pol2qm74 4345 43 30KD 30kd CD cord-015021-pol2qm74 4345 44 , , , cord-015021-pol2qm74 4345 45 and and CC cord-015021-pol2qm74 4345 46 more more JJR cord-015021-pol2qm74 4345 47 than than IN cord-015021-pol2qm74 4345 48 30KD 30kd CD cord-015021-pol2qm74 4345 49 . . . cord-015021-pol2qm74 4346 1 Each each DT cord-015021-pol2qm74 4346 2 group group NN cord-015021-pol2qm74 4346 3 of of IN cord-015021-pol2qm74 4346 4 the the DT cord-015021-pol2qm74 4346 5 substances substance NNS cord-015021-pol2qm74 4346 6 also also RB cord-015021-pol2qm74 4346 7 was be VBD cord-015021-pol2qm74 4346 8 tested test VBN cord-015021-pol2qm74 4346 9 for for IN cord-015021-pol2qm74 4346 10 the the DT cord-015021-pol2qm74 4346 11 expression expression NN cord-015021-pol2qm74 4346 12 of of IN cord-015021-pol2qm74 4346 13 IL-2 IL-2 NNP cord-015021-pol2qm74 4346 14 and and CC cord-015021-pol2qm74 4346 15 IL-2R IL-2R NNP cord-015021-pol2qm74 4346 16 by by IN cord-015021-pol2qm74 4346 17 the the DT cord-015021-pol2qm74 4346 18 dot dot NN cord-015021-pol2qm74 4346 19 blot blot NN cord-015021-pol2qm74 4346 20 hybridization hybridization NN cord-015021-pol2qm74 4346 21 . . . cord-015021-pol2qm74 4347 1 The the DT cord-015021-pol2qm74 4347 2 results result NNS cord-015021-pol2qm74 4347 3 showed show VBD cord-015021-pol2qm74 4347 4 that that IN cord-015021-pol2qm74 4347 5 : : : cord-015021-pol2qm74 4347 6 i i LS cord-015021-pol2qm74 4347 7 ) ) -RRB- cord-015021-pol2qm74 4347 8 All all DT cord-015021-pol2qm74 4347 9 sera sera NNP cord-015021-pol2qm74 4347 10 from from IN cord-015021-pol2qm74 4347 11 the the DT cord-015021-pol2qm74 4347 12 rabbits rabbit NNS cord-015021-pol2qm74 4347 13 after after IN cord-015021-pol2qm74 4347 14 injury injury NN cord-015021-pol2qm74 4347 15 had have VBD cord-015021-pol2qm74 4347 16 significant significant JJ cord-015021-pol2qm74 4347 17 suppression suppression NN cord-015021-pol2qm74 4347 18 on on IN cord-015021-pol2qm74 4347 19 lymphocyte lymphocyte NN cord-015021-pol2qm74 4347 20 proliferation proliferation NN cord-015021-pol2qm74 4347 21 and and CC cord-015021-pol2qm74 4347 22 secretion secretion NN cord-015021-pol2qm74 4347 23 of of IN cord-015021-pol2qm74 4347 24 IL-2 il-2 NN cord-015021-pol2qm74 4347 25 by by IN cord-015021-pol2qm74 4347 26 the the DT cord-015021-pol2qm74 4347 27 Con Con NNP cord-015021-pol2qm74 4347 28 A A NNP cord-015021-pol2qm74 4347 29 - - HYPH cord-015021-pol2qm74 4347 30 stimulated stimulate VBN cord-015021-pol2qm74 4347 31 splenocyte splenocyte NNP cord-015021-pol2qm74 4347 32 in in IN cord-015021-pol2qm74 4347 33 mice mouse NNS cord-015021-pol2qm74 4347 34 ; ; : cord-015021-pol2qm74 4347 35 2 2 CD cord-015021-pol2qm74 4347 36 ) ) -RRB- cord-015021-pol2qm74 4348 1 The the DT cord-015021-pol2qm74 4348 2 sera sera NNP cord-015021-pol2qm74 4348 3 from from IN cord-015021-pol2qm74 4348 4 the the DT cord-015021-pol2qm74 4348 5 rabbits rabbit NNS cord-015021-pol2qm74 4348 6 2 2 CD cord-015021-pol2qm74 4348 7 days day NNS cord-015021-pol2qm74 4348 8 after after IN cord-015021-pol2qm74 4348 9 injury injury NN cord-015021-pol2qm74 4348 10 had have VBD cord-015021-pol2qm74 4348 11 more more RBR cord-015021-pol2qm74 4348 12 profound profound JJ cord-015021-pol2qm74 4348 13 suppression suppression NN cord-015021-pol2qm74 4348 14 than than IN cord-015021-pol2qm74 4348 15 other other JJ cord-015021-pol2qm74 4348 16 injured injure VBN cord-015021-pol2qm74 4348 17 sera sera NNP cord-015021-pol2qm74 4348 18 ; ; : cord-015021-pol2qm74 4348 19 3 3 LS cord-015021-pol2qm74 4348 20 ) ) -RRB- cord-015021-pol2qm74 4348 21 There there EX cord-015021-pol2qm74 4348 22 was be VBD cord-015021-pol2qm74 4348 23 a a DT cord-015021-pol2qm74 4348 24 marked marked JJ cord-015021-pol2qm74 4348 25 band band NN cord-015021-pol2qm74 4348 26 at at IN cord-015021-pol2qm74 4348 27 about about RB cord-015021-pol2qm74 4348 28 10KD 10kd CD cord-015021-pol2qm74 4348 29 in in IN cord-015021-pol2qm74 4348 30 sera sera NNP cord-015021-pol2qm74 4348 31 from from IN cord-015021-pol2qm74 4348 32 the the DT cord-015021-pol2qm74 4348 33 rabbits rabbit NNS cord-015021-pol2qm74 4348 34 2 2 CD cord-015021-pol2qm74 4348 35 days day NNS cord-015021-pol2qm74 4348 36 after after IN cord-015021-pol2qm74 4348 37 injury injury NN cord-015021-pol2qm74 4348 38 , , , cord-015021-pol2qm74 4348 39 but but CC cord-015021-pol2qm74 4348 40 nothing nothing NN cord-015021-pol2qm74 4348 41 at at IN cord-015021-pol2qm74 4348 42 the the DT cord-015021-pol2qm74 4348 43 same same JJ cord-015021-pol2qm74 4348 44 position position NN cord-015021-pol2qm74 4348 45 in in IN cord-015021-pol2qm74 4348 46 normal normal JJ cord-015021-pol2qm74 4348 47 sera sera NNP cord-015021-pol2qm74 4348 48 analyzed analyze VBD cord-015021-pol2qm74 4348 49 with with IN cord-015021-pol2qm74 4348 50 electrophoresis electrophoresis NN cord-015021-pol2qm74 4348 51 ; ; : cord-015021-pol2qm74 4348 52 4 4 LS cord-015021-pol2qm74 4348 53 ) ) -RRB- cord-015021-pol2qm74 4349 1 The the DT cord-015021-pol2qm74 4349 2 substance substance NN cord-015021-pol2qm74 4349 3 with with IN cord-015021-pol2qm74 4349 4 molecular molecular JJ cord-015021-pol2qm74 4349 5 weight weight NN cord-015021-pol2qm74 4349 6 of of IN cord-015021-pol2qm74 4349 7 about about RB cord-015021-pol2qm74 4349 8 IOKD IOKD NNP cord-015021-pol2qm74 4349 9 had have VBD cord-015021-pol2qm74 4349 10 more more RBR cord-015021-pol2qm74 4349 11 obvious obvious JJ cord-015021-pol2qm74 4349 12 suppressive suppressive JJ cord-015021-pol2qm74 4349 13 action action NN cord-015021-pol2qm74 4349 14 on on IN cord-015021-pol2qm74 4349 15 expression expression NN cord-015021-pol2qm74 4349 16 of of IN cord-015021-pol2qm74 4349 17 mRNA mrna NN cord-015021-pol2qm74 4349 18 of of IN cord-015021-pol2qm74 4349 19 IL-2 IL-2 NNP cord-015021-pol2qm74 4349 20 and and CC cord-015021-pol2qm74 4349 21 IL-2R IL-2R NNP cord-015021-pol2qm74 4349 22 than than IN cord-015021-pol2qm74 4349 23 other other JJ cord-015021-pol2qm74 4349 24 groups group NNS cord-015021-pol2qm74 4349 25 substances substance NNS cord-015021-pol2qm74 4349 26 , , , cord-015021-pol2qm74 4349 27 of of IN cord-015021-pol2qm74 4349 28 which which WDT cord-015021-pol2qm74 4349 29 molecular molecular JJ cord-015021-pol2qm74 4349 30 weights weight NNS cord-015021-pol2qm74 4349 31 are be VBP cord-015021-pol2qm74 4349 32 more more JJR cord-015021-pol2qm74 4349 33 than than IN cord-015021-pol2qm74 4349 34 10KD 10kd CD cord-015021-pol2qm74 4349 35 . . . cord-015021-pol2qm74 4350 1 It -PRON- PRP cord-015021-pol2qm74 4350 2 is be VBZ cord-015021-pol2qm74 4350 3 concluded conclude VBN cord-015021-pol2qm74 4350 4 that that IN cord-015021-pol2qm74 4350 5 : : : cord-015021-pol2qm74 4350 6 I i NN cord-015021-pol2qm74 4350 7 ) ) -RRB- cord-015021-pol2qm74 4351 1 The the DT cord-015021-pol2qm74 4351 2 sera sera NNP cord-015021-pol2qm74 4351 3 from from IN cord-015021-pol2qm74 4351 4 the the DT cord-015021-pol2qm74 4351 5 injured injure VBN cord-015021-pol2qm74 4351 6 rabbits rabbit NNS cord-015021-pol2qm74 4351 7 can can MD cord-015021-pol2qm74 4351 8 reduce reduce VB cord-015021-pol2qm74 4351 9 immune immune JJ cord-015021-pol2qm74 4351 10 response response NN cord-015021-pol2qm74 4351 11 ; ; : cord-015021-pol2qm74 4351 12 2 2 LS cord-015021-pol2qm74 4351 13 ) ) -RRB- cord-015021-pol2qm74 4351 14 There there EX cord-015021-pol2qm74 4351 15 is be VBZ cord-015021-pol2qm74 4351 16 kind kind RB cord-015021-pol2qm74 4351 17 of of IN cord-015021-pol2qm74 4351 18 substance substance NN cord-015021-pol2qm74 4351 19 , , , cord-015021-pol2qm74 4351 20 of of IN cord-015021-pol2qm74 4351 21 which which WDT cord-015021-pol2qm74 4351 22 molecular molecular JJ cord-015021-pol2qm74 4351 23 weight weight NN cord-015021-pol2qm74 4351 24 is be VBZ cord-015021-pol2qm74 4351 25 about about RB cord-015021-pol2qm74 4351 26 10KD 10kd CD cord-015021-pol2qm74 4351 27 , , , cord-015021-pol2qm74 4351 28 it -PRON- PRP cord-015021-pol2qm74 4351 29 is be VBZ cord-015021-pol2qm74 4351 30 probable probable JJ cord-015021-pol2qm74 4351 31 the the DT cord-015021-pol2qm74 4351 32 main main JJ cord-015021-pol2qm74 4351 33 factor factor NN cord-015021-pol2qm74 4351 34 involved involve VBN cord-015021-pol2qm74 4351 35 in in IN cord-015021-pol2qm74 4351 36 the the DT cord-015021-pol2qm74 4351 37 pathogenesie pathogenesie NNP cord-015021-pol2qm74 4351 38 of of IN cord-015021-pol2qm74 4351 39 postinjury postinjury NNP cord-015021-pol2qm74 4351 40 suppression suppression NNP cord-015021-pol2qm74 4351 41 immune immune NNP cord-015021-pol2qm74 4351 42 ; ; : cord-015021-pol2qm74 4351 43 3 3 LS cord-015021-pol2qm74 4351 44 } } -RRB- cord-015021-pol2qm74 4351 45 The the DT cord-015021-pol2qm74 4351 46 substance substance NN cord-015021-pol2qm74 4351 47 can can MD cord-015021-pol2qm74 4351 48 depress depress VB cord-015021-pol2qm74 4351 49 the the DT cord-015021-pol2qm74 4351 50 expression expression NN cord-015021-pol2qm74 4351 51 of of IN cord-015021-pol2qm74 4351 52 mRNA mrna NN cord-015021-pol2qm74 4351 53 of of IN cord-015021-pol2qm74 4351 54 both both CC cord-015021-pol2qm74 4351 55 IL-2 IL-2 NNP cord-015021-pol2qm74 4351 56 and and CC cord-015021-pol2qm74 4351 57 IL-2R. IL-2R. NNP cord-015021-pol2qm74 4351 58 Research Research NNP cord-015021-pol2qm74 4351 59 Institute Institute NNP cord-015021-pol2qm74 4351 60 of of IN cord-015021-pol2qm74 4351 61 Surgery Surgery NNP cord-015021-pol2qm74 4351 62 Daping Daping NNP cord-015021-pol2qm74 4351 63 , , , cord-015021-pol2qm74 4351 64 Chongqing Chongqing NNP cord-015021-pol2qm74 4351 65 , , , cord-015021-pol2qm74 4351 66 630042 630042 CD cord-015021-pol2qm74 4351 67 P. P. NNP cord-015021-pol2qm74 4351 68 R. R. NNP cord-015021-pol2qm74 4351 69 China China NNP cord-015021-pol2qm74 4351 70 Acute acute JJ cord-015021-pol2qm74 4351 71 ethanol ethanol NN cord-015021-pol2qm74 4351 72 uptake uptake NN cord-015021-pol2qm74 4351 73 prior prior RB cord-015021-pol2qm74 4351 74 to to IN cord-015021-pol2qm74 4351 75 injury injury NN cord-015021-pol2qm74 4351 76 modulates modulate VBZ cord-015021-pol2qm74 4351 77 monocyte monocyte NNP cord-015021-pol2qm74 4351 78 TNFo~ TNFo~ NNP cord-015021-pol2qm74 4351 79 , , , cord-015021-pol2qm74 4351 80 production production NN cord-015021-pol2qm74 4351 81 and and CC cord-015021-pol2qm74 4351 82 mononuclear mononuclear JJ cord-015021-pol2qm74 4351 83 cell cell NN cord-015021-pol2qm74 4351 84 apoptosis apoptosis NN cord-015021-pol2qm74 4351 85 . . . cord-015021-pol2qm74 4352 1 G. G. NNP cord-015021-pol2qm74 4352 2 Szabo Szabo NNP cord-015021-pol2qm74 4352 3 , , , cord-015021-pol2qm74 4352 4 B. B. NNP cord-015021-pol2qm74 4352 5 Verma Verma NNP cord-015021-pol2qm74 4352 6 , , , cord-015021-pol2qm74 4352 7 P. P. NNP cord-015021-pol2qm74 4352 8 Mandrekar Mandrekar NNP cord-015021-pol2qm74 4352 9 , , , cord-015021-pol2qm74 4352 10 D. D. NNP cord-015021-pol2qm74 4352 11 Catalano Catalano NNP cord-015021-pol2qm74 4352 12 Monocytes Monocytes NNP cord-015021-pol2qm74 4352 13 ( ( -LRB- cord-015021-pol2qm74 4352 14 MO MO NNP cord-015021-pol2qm74 4352 15 ) ) -RRB- cord-015021-pol2qm74 4352 16 have have VBP cord-015021-pol2qm74 4352 17 been be VBN cord-015021-pol2qm74 4352 18 shown show VBN cord-015021-pol2qm74 4352 19 to to TO cord-015021-pol2qm74 4352 20 contribute contribute VB cord-015021-pol2qm74 4352 21 to to IN cord-015021-pol2qm74 4352 22 immunosuppression immunosuppression NN cord-015021-pol2qm74 4352 23 after after IN cord-015021-pol2qm74 4352 24 both both DT cord-015021-pol2qm74 4352 25 major major JJ cord-015021-pol2qm74 4352 26 injury injury NN cord-015021-pol2qm74 4352 27 and and CC cord-015021-pol2qm74 4352 28 alcohol alcohol NN cord-015021-pol2qm74 4352 29 consumption consumption NN cord-015021-pol2qm74 4352 30 . . . cord-015021-pol2qm74 4353 1 We -PRON- PRP cord-015021-pol2qm74 4353 2 reported report VBD cord-015021-pol2qm74 4353 3 that that IN cord-015021-pol2qm74 4353 4 acute acute JJ cord-015021-pol2qm74 4353 5 ethanol ethanol NN cord-015021-pol2qm74 4353 6 exposure exposure NN cord-015021-pol2qm74 4353 7 of of IN cord-015021-pol2qm74 4353 8 M(3 M(3 NNP cord-015021-pol2qm74 4353 9 results result NNS cord-015021-pol2qm74 4353 10 in in IN cord-015021-pol2qm74 4353 11 decreased decrease VBN cord-015021-pol2qm74 4353 12 antigen antigen NN cord-015021-pol2qm74 4353 13 presentation presentation NN cord-015021-pol2qm74 4353 14 , , , cord-015021-pol2qm74 4353 15 induces induce VBZ cord-015021-pol2qm74 4353 16 TGF-13 TGF-13 NNP cord-015021-pol2qm74 4353 17 and and CC cord-015021-pol2qm74 4353 18 PGE2 PGE2 NNP cord-015021-pol2qm74 4353 19 while while IN cord-015021-pol2qm74 4353 20 inhibiting inhibit VBG cord-015021-pol2qm74 4353 21 inflammatory inflammatory JJ cord-015021-pol2qm74 4353 22 monokine monokine JJ cord-015021-pol2qm74 4353 23 production production NN cord-015021-pol2qm74 4353 24 . . . cord-015021-pol2qm74 4354 1 We -PRON- PRP cord-015021-pol2qm74 4354 2 also also RB cord-015021-pol2qm74 4354 3 showed show VBD cord-015021-pol2qm74 4354 4 that that IN cord-015021-pol2qm74 4354 5 post post JJ cord-015021-pol2qm74 4354 6 - - JJ cord-015021-pol2qm74 4354 7 trauma trauma JJ cord-015021-pol2qm74 4354 8 immunosuppression immunosuppression NN cord-015021-pol2qm74 4354 9 is be VBZ cord-015021-pol2qm74 4354 10 mediated mediate VBN cord-015021-pol2qm74 4354 11 by by IN cord-015021-pol2qm74 4355 1 hyper hyper JJ cord-015021-pol2qm74 4355 2 - - JJ cord-015021-pol2qm74 4355 3 elevated elevated JJ cord-015021-pol2qm74 4355 4 MO MO NNP cord-015021-pol2qm74 4355 5 TNFc~ TNFc~ NNP cord-015021-pol2qm74 4355 6 and and CC cord-015021-pol2qm74 4355 7 IL-6 IL-6 NNP cord-015021-pol2qm74 4355 8 . . . cord-015021-pol2qm74 4356 1 Consequently consequently RB cord-015021-pol2qm74 4356 2 , , , cord-015021-pol2qm74 4356 3 here here RB cord-015021-pol2qm74 4356 4 we -PRON- PRP cord-015021-pol2qm74 4356 5 investigated investigate VBD cord-015021-pol2qm74 4356 6 rnonokine rnonokine JJ cord-015021-pol2qm74 4356 7 production production NN cord-015021-pol2qm74 4356 8 in in IN cord-015021-pol2qm74 4356 9 trauma trauma NN cord-015021-pol2qm74 4356 10 patients patient NNS cord-015021-pol2qm74 4356 11 ( ( -LRB- cord-015021-pol2qm74 4356 12 n=10 n=10 NNP cord-015021-pol2qm74 4356 13 ) ) -RRB- cord-015021-pol2qm74 4356 14 who who WP cord-015021-pol2qm74 4356 15 had have VBD cord-015021-pol2qm74 4356 16 elevated elevate VBN cord-015021-pol2qm74 4356 17 ( ( -LRB- cord-015021-pol2qm74 4356 18 > > XX cord-015021-pol2qm74 4356 19 O.lmg/dl O.lmg/dl NNP cord-015021-pol2qm74 4356 20 ) ) -RRB- cord-015021-pol2qm74 4356 21 or or CC cord-015021-pol2qm74 4356 22 had have VBD cord-015021-pol2qm74 4356 23 no no DT cord-015021-pol2qm74 4356 24 blood blood NN cord-015021-pol2qm74 4356 25 alcohol alcohol NN cord-015021-pol2qm74 4356 26 level level NN cord-015021-pol2qm74 4356 27 ( ( -LRB- cord-015021-pol2qm74 4356 28 n n NN cord-015021-pol2qm74 4356 29 = = NN cord-015021-pol2qm74 4356 30 t0 t0 NNP cord-015021-pol2qm74 4356 31 ) ) -RRB- cord-015021-pol2qm74 4356 32 at at IN cord-015021-pol2qm74 4356 33 the the DT cord-015021-pol2qm74 4356 34 time time NN cord-015021-pol2qm74 4356 35 of of IN cord-015021-pol2qm74 4356 36 emergency emergency NN cord-015021-pol2qm74 4356 37 room room NN cord-015021-pol2qm74 4356 38 admission admission NN cord-015021-pol2qm74 4356 39 . . . cord-015021-pol2qm74 4357 1 None none NN cord-015021-pol2qm74 4357 2 of of IN cord-015021-pol2qm74 4357 3 the the DT cord-015021-pol2qm74 4357 4 patients patient NNS cord-015021-pol2qm74 4357 5 had have VBD cord-015021-pol2qm74 4357 6 chronic chronic JJ cord-015021-pol2qm74 4357 7 alcohol alcohol NN cord-015021-pol2qm74 4357 8 use use NN cord-015021-pol2qm74 4357 9 history history NN cord-015021-pol2qm74 4357 10 . . . cord-015021-pol2qm74 4358 1 Met Met NNP cord-015021-pol2qm74 4358 2 TNFc~ tnfc~ IN cord-015021-pol2qm74 4358 3 production production NN cord-015021-pol2qm74 4358 4 from from IN cord-015021-pol2qm74 4358 5 trauma trauma NN cord-015021-pol2qm74 4358 6 patients patient NNS cord-015021-pol2qm74 4358 7 with with IN cord-015021-pol2qm74 4358 8 prior prior JJ cord-015021-pol2qm74 4358 9 alcohol alcohol NN cord-015021-pol2qm74 4358 10 uptake uptake NN cord-015021-pol2qm74 4358 11 was be VBD cord-015021-pol2qm74 4358 12 undetectable undetectable JJ cord-015021-pol2qm74 4358 13 during during IN cord-015021-pol2qm74 4358 14 days day NNS cord-015021-pol2qm74 4358 15 0 0 CD cord-015021-pol2qm74 4358 16 - - SYM cord-015021-pol2qm74 4358 17 3 3 CD cord-015021-pol2qm74 4358 18 post post JJ cord-015021-pol2qm74 4358 19 - - JJ cord-015021-pol2qm74 4358 20 injury injury NN cord-015021-pol2qm74 4358 21 in in IN cord-015021-pol2qm74 4358 22 contrast contrast NN cord-015021-pol2qm74 4358 23 to to IN cord-015021-pol2qm74 4358 24 patients patient NNS cord-015021-pol2qm74 4358 25 without without IN cord-015021-pol2qm74 4358 26 alcohol alcohol NN cord-015021-pol2qm74 4358 27 exposure exposure NN cord-015021-pol2qm74 4358 28 . . . cord-015021-pol2qm74 4359 1 Furthermore furthermore RB cord-015021-pol2qm74 4359 2 , , , cord-015021-pol2qm74 4359 3 decreased decrease VBD cord-015021-pol2qm74 4359 4 TNF TNF NNP cord-015021-pol2qm74 4360 1 ~x ~x NNP cord-015021-pol2qm74 4360 2 levels level NNS cord-015021-pol2qm74 4360 3 were be VBD cord-015021-pol2qm74 4360 4 found find VBN cord-015021-pol2qm74 4360 5 in in IN cord-015021-pol2qm74 4360 6 alcoholic alcoholic JJ cord-015021-pol2qm74 4360 7 patients patient NNS cord-015021-pol2qm74 4360 8 ' ' POS cord-015021-pol2qm74 4360 9 MCi MCi NNS cord-015021-pol2qm74 4360 10 after after IN cord-015021-pol2qm74 4360 11 MDP MDP NNP cord-015021-pol2qm74 4360 12 or or CC cord-015021-pol2qm74 4360 13 IFNy IFNy NNPS cord-015021-pol2qm74 4360 14 + + CC cord-015021-pol2qm74 4361 1 MDP MDP NNP cord-015021-pol2qm74 4361 2 induction induction NN cord-015021-pol2qm74 4361 3 . . . cord-015021-pol2qm74 4362 1 However however RB cord-015021-pol2qm74 4362 2 , , , cord-015021-pol2qm74 4362 3 MCl MCl NNS cord-015021-pol2qm74 4362 4 TNFc~ tnfc~ IN cord-015021-pol2qm74 4362 5 levels level NNS cord-015021-pol2qm74 4362 6 during during IN cord-015021-pol2qm74 4362 7 the the DT cord-015021-pol2qm74 4362 8 4 4 CD cord-015021-pol2qm74 4362 9 - - SYM cord-015021-pol2qm74 4362 10 8 8 CD cord-015021-pol2qm74 4362 11 days day NNS cord-015021-pol2qm74 4362 12 post post NN cord-015021-pol2qm74 4362 13 injury injury NN cord-015021-pol2qm74 4362 14 period period NN cord-015021-pol2qm74 4362 15 became become VBD cord-015021-pol2qm74 4362 16 higher high JJR cord-015021-pol2qm74 4362 17 in in IN cord-015021-pol2qm74 4362 18 alcoholic alcoholic JJ cord-015021-pol2qm74 4362 19 trauma trauma NN cord-015021-pol2qm74 4362 20 patients patient NNS cord-015021-pol2qm74 4362 21 . . . cord-015021-pol2qm74 4363 1 Furthermore furthermore RB cord-015021-pol2qm74 4363 2 , , , cord-015021-pol2qm74 4363 3 over over IN cord-015021-pol2qm74 4363 4 9 9 CD cord-015021-pol2qm74 4363 5 days day NNS cord-015021-pol2qm74 4363 6 post post NN cord-015021-pol2qm74 4363 7 - - JJ cord-015021-pol2qm74 4363 8 injury injury JJ cord-015021-pol2qm74 4363 9 , , , cord-015021-pol2qm74 4363 10 alcoholic alcoholic JJ cord-015021-pol2qm74 4363 11 trauma trauma NN cord-015021-pol2qm74 4363 12 patients patient NNS cord-015021-pol2qm74 4363 13 showed show VBD cord-015021-pol2qm74 4363 14 significantly significantly RB cord-015021-pol2qm74 4363 15 elevated elevated JJ cord-015021-pol2qm74 4363 16 MCi MCi NNS cord-015021-pol2qm74 4363 17 TNFo~ TNFo~ NNS cord-015021-pol2qm74 4363 18 production production NN cord-015021-pol2qm74 4363 19 after after IN cord-015021-pol2qm74 4363 20 adherence adherence NN cord-015021-pol2qm74 4363 21 isolation isolation NN cord-015021-pol2qm74 4363 22 , , , cord-015021-pol2qm74 4363 23 MDP MDP NNP cord-015021-pol2qm74 4363 24 , , , cord-015021-pol2qm74 4363 25 or or CC cord-015021-pol2qm74 4363 26 IFN+MDP ifn+mdp JJ cord-015021-pol2qm74 4363 27 stimulation stimulation NN cord-015021-pol2qm74 4363 28 compared compare VBN cord-015021-pol2qm74 4363 29 to to IN cord-015021-pol2qm74 4363 30 patients patient NNS cord-015021-pol2qm74 4363 31 without without IN cord-015021-pol2qm74 4363 32 alcohol alcohol NN cord-015021-pol2qm74 4363 33 . . . cord-015021-pol2qm74 4364 1 These these DT cord-015021-pol2qm74 4364 2 results result NNS cord-015021-pol2qm74 4364 3 suggest suggest VBP cord-015021-pol2qm74 4364 4 that that IN cord-015021-pol2qm74 4364 5 acute acute JJ cord-015021-pol2qm74 4364 6 ethanol ethanol NN cord-015021-pol2qm74 4364 7 uptake uptake NN cord-015021-pol2qm74 4364 8 prior prior RB cord-015021-pol2qm74 4364 9 to to IN cord-015021-pol2qm74 4364 10 injury injury NN cord-015021-pol2qm74 4364 11 decreases decrease VBZ cord-015021-pol2qm74 4364 12 TNF(x tnf(x NN cord-015021-pol2qm74 4364 13 inducibility inducibility NN cord-015021-pol2qm74 4364 14 in in IN cord-015021-pol2qm74 4364 15 the the DT cord-015021-pol2qm74 4364 16 early early JJ cord-015021-pol2qm74 4364 17 post post JJ cord-015021-pol2qm74 4364 18 - - JJ cord-015021-pol2qm74 4364 19 trauma trauma JJ cord-015021-pol2qm74 4364 20 period period NN cord-015021-pol2qm74 4364 21 , , , cord-015021-pol2qm74 4364 22 but but CC cord-015021-pol2qm74 4365 1 these these DT cord-015021-pol2qm74 4365 2 patients patient NNS cord-015021-pol2qm74 4365 3 ' ' POS cord-015021-pol2qm74 4365 4 MO MO NNP cord-015021-pol2qm74 4365 5 produce produce VBP cord-015021-pol2qm74 4365 6 hyper hyper JJ cord-015021-pol2qm74 4365 7 - - JJ cord-015021-pol2qm74 4365 8 elevated elevated JJ cord-015021-pol2qm74 4365 9 TNFa TNFa NNS cord-015021-pol2qm74 4365 10 levels level NNS cord-015021-pol2qm74 4365 11 later later RB cord-015021-pol2qm74 4365 12 post post JJ cord-015021-pol2qm74 4365 13 - - JJ cord-015021-pol2qm74 4365 14 injury injury NN cord-015021-pol2qm74 4365 15 , , , cord-015021-pol2qm74 4365 16 thereby thereby RB cord-015021-pol2qm74 4365 17 prolonging prolong VBG cord-015021-pol2qm74 4365 18 their -PRON- PRP$ cord-015021-pol2qm74 4365 19 cytokine cytokine NN cord-015021-pol2qm74 4365 20 shock shock NN cord-015021-pol2qm74 4365 21 risk risk NN cord-015021-pol2qm74 4365 22 . . . cord-015021-pol2qm74 4366 1 TNF TNF NNP cord-015021-pol2qm74 4366 2 ng ng NNP cord-015021-pol2qm74 4366 3 / / SYM cord-015021-pol2qm74 4366 4 ml ml NN cord-015021-pol2qm74 4366 5 0 0 CD cord-015021-pol2qm74 4366 6 - - SYM cord-015021-pol2qm74 4366 7 3 3 CD cord-015021-pol2qm74 4366 8 days day NNS cord-015021-pol2qm74 4366 9 post post JJ cord-015021-pol2qm74 4366 10 - - JJ cord-015021-pol2qm74 4366 11 injury injury NN cord-015021-pol2qm74 4367 1 9 9 CD cord-015021-pol2qm74 4367 2 days day NNS cord-015021-pol2qm74 4367 3 post post VBP cord-015021-pol2qm74 4367 4 injury injury NN cord-015021-pol2qm74 4367 5 Stimulus Stimulus NNP cord-015021-pol2qm74 4367 6 Ale Ale NNP cord-015021-pol2qm74 4367 7 . . . cord-015021-pol2qm74 4368 1 Pt Pt NNP cord-015021-pol2qm74 4368 2 . . . cord-015021-pol2qm74 4369 1 Pt Pt NNP cord-015021-pol2qm74 4369 2 9.3 9.3 CD cord-015021-pol2qm74 4369 3 11.9 11.9 CD cord-015021-pol2qm74 4369 4 5.6 5.6 CD cord-015021-pol2qm74 4369 5 4.0 4.0 CD cord-015021-pol2qm74 4369 6 Immunosuppression Immunosuppression NNP cord-015021-pol2qm74 4369 7 might may MD cord-015021-pol2qm74 4369 8 also also RB cord-015021-pol2qm74 4369 9 be be VB cord-015021-pol2qm74 4369 10 increased increase VBN cord-015021-pol2qm74 4369 11 by by IN cord-015021-pol2qm74 4369 12 the the DT cord-015021-pol2qm74 4369 13 elevated elevated JJ cord-015021-pol2qm74 4369 14 apoptotic apoptotic JJ cord-015021-pol2qm74 4369 15 activity activity NN cord-015021-pol2qm74 4369 16 found find VBN cord-015021-pol2qm74 4369 17 in in IN cord-015021-pol2qm74 4369 18 trauma trauma NN cord-015021-pol2qm74 4369 19 patients patient NNS cord-015021-pol2qm74 4369 20 ' ' POS cord-015021-pol2qm74 4369 21 mononuclear mononuclear JJ cord-015021-pol2qm74 4369 22 ceils ceil NNS cord-015021-pol2qm74 4369 23 , , , cord-015021-pol2qm74 4369 24 which which WDT cord-015021-pol2qm74 4369 25 was be VBD cord-015021-pol2qm74 4369 26 even even RB cord-015021-pol2qm74 4369 27 greater great JJR cord-015021-pol2qm74 4369 28 in in IN cord-015021-pol2qm74 4369 29 alcoholic alcoholic JJ cord-015021-pol2qm74 4369 30 trauma trauma NN cord-015021-pol2qm74 4369 31 patients patient NNS cord-015021-pol2qm74 4369 32 ' ' POS cord-015021-pol2qm74 4369 33 cells cell NNS cord-015021-pol2qm74 4369 34 . . . cord-015021-pol2qm74 4370 1 In in IN cord-015021-pol2qm74 4370 2 non non JJ cord-015021-pol2qm74 4370 3 - - JJ cord-015021-pol2qm74 4370 4 alcoholic alcoholic JJ cord-015021-pol2qm74 4370 5 trauma trauma NN cord-015021-pol2qm74 4370 6 patients patient NNS cord-015021-pol2qm74 4370 7 ' ' POS cord-015021-pol2qm74 4370 8 preactivated preactivated JJ cord-015021-pol2qm74 4370 9 MO MO NNP cord-015021-pol2qm74 4370 10 , , , cord-015021-pol2qm74 4370 11 in in IN cord-015021-pol2qm74 4370 12 vitro vitro FW cord-015021-pol2qm74 4370 13 acute acute JJ cord-015021-pol2qm74 4370 14 ethanol ethanol NN cord-015021-pol2qm74 4370 15 ( ( -LRB- cord-015021-pol2qm74 4370 16 25 25 CD cord-015021-pol2qm74 4370 17 - - HYPH cord-015021-pol2qm74 4370 18 150mM 150mm CD cord-015021-pol2qm74 4370 19 ) ) -RRB- cord-015021-pol2qm74 4370 20 exposure exposure NN cord-015021-pol2qm74 4370 21 resulted result VBD cord-015021-pol2qm74 4370 22 in in IN cord-015021-pol2qm74 4370 23 a a DT cord-015021-pol2qm74 4370 24 significant significant JJ cord-015021-pol2qm74 4370 25 down down NN cord-015021-pol2qm74 4370 26 - - HYPH cord-015021-pol2qm74 4370 27 regulation regulation NN cord-015021-pol2qm74 4370 28 of of IN cord-015021-pol2qm74 4370 29 TNFc~ TNFc~ NNP cord-015021-pol2qm74 4370 30 ( ( -LRB- cord-015021-pol2qm74 4370 31 p<0.001 p<0.001 CD cord-015021-pol2qm74 4370 32 ) ) -RRB- cord-015021-pol2qm74 4370 33 and and CC cord-015021-pol2qm74 4371 1 IL-6 IL-6 NNP cord-015021-pol2qm74 4371 2 ( ( -LRB- cord-015021-pol2qm74 4371 3 p<0.01 p<0.01 NNP cord-015021-pol2qm74 4371 4 ) ) -RRB- cord-015021-pol2qm74 4371 5 production production NN cord-015021-pol2qm74 4371 6 . . . cord-015021-pol2qm74 4372 1 In in IN cord-015021-pol2qm74 4372 2 contrast contrast NN cord-015021-pol2qm74 4372 3 , , , cord-015021-pol2qm74 4372 4 in in IN cord-015021-pol2qm74 4372 5 vitro vitro FW cord-015021-pol2qm74 4372 6 ethanol ethanol NN cord-015021-pol2qm74 4372 7 exposure exposure NN cord-015021-pol2qm74 4372 8 increased increase VBD cord-015021-pol2qm74 4372 9 the the DT cord-015021-pol2qm74 4372 10 production production NN cord-015021-pol2qm74 4372 11 of of IN cord-015021-pol2qm74 4372 12 inhibitory inhibitory JJ cord-015021-pol2qm74 4372 13 monokine monokine NN cord-015021-pol2qm74 4372 14 , , , cord-015021-pol2qm74 4372 15 TGFI TGFI NNP cord-015021-pol2qm74 4372 16 ] ] -RRB- cord-015021-pol2qm74 4372 17 . . . cord-015021-pol2qm74 4373 1 These these DT cord-015021-pol2qm74 4373 2 results result NNS cord-015021-pol2qm74 4373 3 provide provide VBP cord-015021-pol2qm74 4373 4 both both DT cord-015021-pol2qm74 4373 5 in in IN cord-015021-pol2qm74 4373 6 vivo vivo NN cord-015021-pol2qm74 4373 7 and and CC cord-015021-pol2qm74 4373 8 in in IN cord-015021-pol2qm74 4373 9 vitro vitro FW cord-015021-pol2qm74 4373 10 evidence evidence NN cord-015021-pol2qm74 4373 11 for for IN cord-015021-pol2qm74 4373 12 the the DT cord-015021-pol2qm74 4373 13 effect effect NN cord-015021-pol2qm74 4373 14 of of IN cord-015021-pol2qm74 4373 15 acute acute JJ cord-015021-pol2qm74 4373 16 ethanol ethanol NN cord-015021-pol2qm74 4373 17 exposure exposure NN cord-015021-pol2qm74 4373 18 increasing increase VBG cord-015021-pol2qm74 4373 19 immunosuppression immunosuppression NN cord-015021-pol2qm74 4373 20 and and CC cord-015021-pol2qm74 4373 21 cytokine cytokine NN cord-015021-pol2qm74 4373 22 shock shock NN cord-015021-pol2qm74 4373 23 . . . cord-015021-pol2qm74 4374 1 The the DT cord-015021-pol2qm74 4374 2 ' ' `` cord-015021-pol2qm74 4374 3 systemic systemic JJ cord-015021-pol2qm74 4374 4 inflammatory inflammatory JJ cord-015021-pol2qm74 4374 5 response response NN cord-015021-pol2qm74 4374 6 syndrome syndrome NN cord-015021-pol2qm74 4374 7 ' ' '' cord-015021-pol2qm74 4374 8 ( ( -LRB- cord-015021-pol2qm74 4374 9 SIRS sirs UH cord-015021-pol2qm74 4374 10 ) ) -RRB- cord-015021-pol2qm74 4374 11 with with IN cord-015021-pol2qm74 4374 12 consecutive consecutive JJ cord-015021-pol2qm74 4374 13 septic septic JJ cord-015021-pol2qm74 4374 14 multi multi JJ cord-015021-pol2qm74 4374 15 - - JJ cord-015021-pol2qm74 4374 16 organ organ JJ cord-015021-pol2qm74 4374 17 dysfunction dysfunction NN cord-015021-pol2qm74 4374 18 represents represent VBZ cord-015021-pol2qm74 4374 19 the the DT cord-015021-pol2qm74 4374 20 major major JJ cord-015021-pol2qm74 4374 21 cause cause NN cord-015021-pol2qm74 4374 22 of of IN cord-015021-pol2qm74 4374 23 late late JJ cord-015021-pol2qm74 4374 24 death death NN cord-015021-pol2qm74 4374 25 following follow VBG cord-015021-pol2qm74 4374 26 major major JJ cord-015021-pol2qm74 4374 27 mechanical mechanical JJ cord-015021-pol2qm74 4374 28 and and CC cord-015021-pol2qm74 4374 29 burn burn VB cord-015021-pol2qm74 4374 30 trauma trauma NN cord-015021-pol2qm74 4374 31 . . . cord-015021-pol2qm74 4375 1 Systemic systemic JJ cord-015021-pol2qm74 4375 2 hyperinflammation hyperinflammation NN cord-015021-pol2qm74 4375 3 and and CC cord-015021-pol2qm74 4375 4 concurrent concurrent JJ cord-015021-pol2qm74 4375 5 depression depression NN cord-015021-pol2qm74 4375 6 of of IN cord-015021-pol2qm74 4375 7 cell cell NN cord-015021-pol2qm74 4375 8 mediated mediate VBN cord-015021-pol2qm74 4375 9 immune immune JJ cord-015021-pol2qm74 4375 10 response response NN cord-015021-pol2qm74 4375 11 ( ( -LRB- cord-015021-pol2qm74 4375 12 CMI CMI NNP cord-015021-pol2qm74 4375 13 ) ) -RRB- cord-015021-pol2qm74 4375 14 render render VBP cord-015021-pol2qm74 4375 15 the the DT cord-015021-pol2qm74 4375 16 traumatized traumatize VBN cord-015021-pol2qm74 4375 17 host host NN cord-015021-pol2qm74 4375 18 anergic anergic NN cord-015021-pol2qm74 4375 19 , , , cord-015021-pol2qm74 4375 20 resulting result VBG cord-015021-pol2qm74 4375 21 in in IN cord-015021-pol2qm74 4375 22 profound profound JJ cord-015021-pol2qm74 4375 23 susceptibility susceptibility NN cord-015021-pol2qm74 4375 24 to to IN cord-015021-pol2qm74 4375 25 opportunistic opportunistic JJ cord-015021-pol2qm74 4375 26 infection infection NN cord-015021-pol2qm74 4375 27 . . . cord-015021-pol2qm74 4376 1 Monooytes monooyte NNS cord-015021-pol2qm74 4376 2 / / SYM cord-015021-pol2qm74 4376 3 macrophages macrophage NNS cord-015021-pol2qm74 4376 4 ( ( -LRB- cord-015021-pol2qm74 4376 5 MO MO NNP cord-015021-pol2qm74 4376 6 ) ) -RRB- cord-015021-pol2qm74 4376 7 play play VBP cord-015021-pol2qm74 4376 8 a a DT cord-015021-pol2qm74 4376 9 central central JJ cord-015021-pol2qm74 4376 10 role role NN cord-015021-pol2qm74 4376 11 within within IN cord-015021-pol2qm74 4376 12 the the DT cord-015021-pol2qm74 4376 13 host host NN cord-015021-pol2qm74 4376 14 defense defense NN cord-015021-pol2qm74 4376 15 system system NN cord-015021-pol2qm74 4376 16 in in IN cord-015021-pol2qm74 4376 17 developing develop VBG cord-015021-pol2qm74 4376 18 and and CC cord-015021-pol2qm74 4376 19 manifesting manifest VBG cord-015021-pol2qm74 4376 20 states state NNS cord-015021-pol2qm74 4376 21 of of IN cord-015021-pol2qm74 4376 22 injury injury NN cord-015021-pol2qm74 4376 23 , , , cord-015021-pol2qm74 4376 24 shock shock NN cord-015021-pol2qm74 4376 25 and and CC cord-015021-pol2qm74 4376 26 sepsis sepsis NN cord-015021-pol2qm74 4376 27 . . . cord-015021-pol2qm74 4377 1 The the DT cord-015021-pol2qm74 4377 2 mechanistic mechanistic JJ cord-015021-pol2qm74 4377 3 scrutiny scrutiny NN cord-015021-pol2qm74 4377 4 of of IN cord-015021-pol2qm74 4377 5 the the DT cord-015021-pol2qm74 4377 6 synthesis synthesis NN cord-015021-pol2qm74 4377 7 patterns pattern NNS cord-015021-pol2qm74 4377 8 of of IN cord-015021-pol2qm74 4377 9 crucial crucial JJ cord-015021-pol2qm74 4377 10 cccytokines cccytokine NNS cord-015021-pol2qm74 4377 11 appears appear VBZ cord-015021-pol2qm74 4377 12 to to TO cord-015021-pol2qm74 4377 13 be be VB cord-015021-pol2qm74 4377 14 a a DT cord-015021-pol2qm74 4377 15 helpful helpful JJ cord-015021-pol2qm74 4377 16 tool tool NN cord-015021-pol2qm74 4377 17 to to TO cord-015021-pol2qm74 4377 18 further further RB cord-015021-pol2qm74 4377 19 analyse analyse VB cord-015021-pol2qm74 4377 20 MO MO NNP cord-015021-pol2qm74 4377 21 behaviour behaviour NN cord-015021-pol2qm74 4377 22 in in IN cord-015021-pol2qm74 4377 23 the the DT cord-015021-pol2qm74 4377 24 compromised compromised JJ cord-015021-pol2qm74 4377 25 individual individual NN cord-015021-pol2qm74 4377 26 . . . cord-015021-pol2qm74 4378 1 The the DT cord-015021-pol2qm74 4378 2 objective objective NN cord-015021-pol2qm74 4378 3 of of IN cord-015021-pol2qm74 4378 4 this this DT cord-015021-pol2qm74 4378 5 study study NN cord-015021-pol2qm74 4378 6 was be VBD cord-015021-pol2qm74 4378 7 to to TO cord-015021-pol2qm74 4378 8 further further RB cord-015021-pol2qm74 4378 9 dissect dissect VB cord-015021-pol2qm74 4378 10 the the DT cord-015021-pol2qm74 4378 11 characteristics characteristic NNS cord-015021-pol2qm74 4378 12 of of IN cord-015021-pol2qm74 4378 13 cytokine cytokine NN cord-015021-pol2qm74 4378 14 regulation regulation NN cord-015021-pol2qm74 4378 15 in in IN cord-015021-pol2qm74 4378 16 PBMC PBMC NNP cord-015021-pol2qm74 4378 17 under under IN cord-015021-pol2qm74 4378 18 stressful stressful JJ cord-015021-pol2qm74 4378 19 conditions condition NNS cord-015021-pol2qm74 4378 20 , , , cord-015021-pol2qm74 4378 21 via via IN cord-015021-pol2qm74 4378 22 analysis analysis NN cord-015021-pol2qm74 4378 23 of of IN cord-015021-pol2qm74 4378 24 the the DT cord-015021-pol2qm74 4378 25 expression expression NN cord-015021-pol2qm74 4378 26 of of IN cord-015021-pol2qm74 4378 27 CD14 CD14 NNP cord-015021-pol2qm74 4378 28 + + CC cord-015021-pol2qm74 4378 29 receptor receptor NN cord-015021-pol2qm74 4378 30 , , , cord-015021-pol2qm74 4378 31 the the DT cord-015021-pol2qm74 4378 32 proinflammatory proinflammatory JJ cord-015021-pol2qm74 4378 33 mediator mediator NN cord-015021-pol2qm74 4378 34 IL-6 IL-6 NNP cord-015021-pol2qm74 4378 35 , , , cord-015021-pol2qm74 4378 36 the the DT cord-015021-pol2qm74 4378 37 macrophage macrophage NN cord-015021-pol2qm74 4378 38 activating activate VBG cord-015021-pol2qm74 4378 39 factor factor NN cord-015021-pol2qm74 4378 40 IFN-5 IFN-5 NNP cord-015021-pol2qm74 4378 41 , , , cord-015021-pol2qm74 4378 42 , , , cord-015021-pol2qm74 4378 43 and and CC cord-015021-pol2qm74 4378 44 Neopterin Neopterin NNP cord-015021-pol2qm74 4378 45 ( ( -LRB- cord-015021-pol2qm74 4378 46 NPT NPT NNP cord-015021-pol2qm74 4378 47 ) ) -RRB- cord-015021-pol2qm74 4378 48 a a DT cord-015021-pol2qm74 4378 49 metabolite metabolite NN cord-015021-pol2qm74 4378 50 of of IN cord-015021-pol2qm74 4378 51 activated activate VBN cord-015021-pol2qm74 4378 52 MO MO NNP cord-015021-pol2qm74 4378 53 . . . cord-015021-pol2qm74 4379 1 We -PRON- PRP cord-015021-pol2qm74 4379 2 investigated investigate VBD cord-015021-pol2qm74 4379 3 PBMC PBMC NNP cord-015021-pol2qm74 4379 4 's 's POS cord-015021-pol2qm74 4379 5 on on IN cord-015021-pol2qm74 4379 6 consecutive consecutive JJ cord-015021-pol2qm74 4379 7 days day NNS cord-015021-pol2qm74 4379 8 1 1 CD cord-015021-pol2qm74 4379 9 , , , cord-015021-pol2qm74 4379 10 3 3 CD cord-015021-pol2qm74 4379 11 , , , cord-015021-pol2qm74 4379 12 5 5 CD cord-015021-pol2qm74 4379 13 , , , cord-015021-pol2qm74 4379 14 7 7 CD cord-015021-pol2qm74 4379 15 and and CC cord-015021-pol2qm74 4379 16 10 10 CD cord-015021-pol2qm74 4379 17 after after IN cord-015021-pol2qm74 4379 18 mechanical mechanical JJ cord-015021-pol2qm74 4379 19 trauma trauma NN cord-015021-pol2qm74 4379 20 of of IN cord-015021-pol2qm74 4379 21 9 9 CD cord-015021-pol2qm74 4379 22 and and CC cord-015021-pol2qm74 4379 23 after after IN cord-015021-pol2qm74 4379 24 bum bum NN cord-015021-pol2qm74 4379 25 trauma trauma NN cord-015021-pol2qm74 4379 26 of of IN cord-015021-pol2qm74 4379 27 5 5 CD cord-015021-pol2qm74 4379 28 patients patient NNS cord-015021-pol2qm74 4379 29 ( ( -LRB- cord-015021-pol2qm74 4379 30 mean mean VB cord-015021-pol2qm74 4379 31 age age NN cord-015021-pol2qm74 4379 32 38~17 38~17 CD cord-015021-pol2qm74 4379 33 years year NNS cord-015021-pol2qm74 4379 34 ; ; : cord-015021-pol2qm74 4379 35 mean mean VB cord-015021-pol2qm74 4379 36 ISS ISS NNP cord-015021-pol2qm74 4379 37 34±2 34±2 CD cord-015021-pol2qm74 4379 38 pts pts NNP cord-015021-pol2qm74 4379 39 ) ) -RRB- cord-015021-pol2qm74 4379 40 . . . cord-015021-pol2qm74 4380 1 In in IN cord-015021-pol2qm74 4380 2 trauma trauma NN cord-015021-pol2qm74 4380 3 patients patient NNS cord-015021-pol2qm74 4380 4 we -PRON- PRP cord-015021-pol2qm74 4380 5 saw see VBD cord-015021-pol2qm74 4380 6 a a DT cord-015021-pol2qm74 4380 7 massive massive JJ cord-015021-pol2qm74 4380 8 increase increase NN cord-015021-pol2qm74 4380 9 of of IN cord-015021-pol2qm74 4380 10 PHA PHA NNP cord-015021-pol2qm74 4380 11 induced induce VBN cord-015021-pol2qm74 4380 12 neopterin neopterin JJ cord-015021-pol2qm74 4380 13 synthesis synthesis NN cord-015021-pol2qm74 4380 14 compared compare VBN cord-015021-pol2qm74 4380 15 to to IN cord-015021-pol2qm74 4380 16 controls control NNS cord-015021-pol2qm74 4380 17 . . . cord-015021-pol2qm74 4381 1 However however RB cord-015021-pol2qm74 4381 2 , , , cord-015021-pol2qm74 4381 3 when when WRB cord-015021-pol2qm74 4381 4 discriminating discriminate VBG cord-015021-pol2qm74 4381 5 the the DT cord-015021-pol2qm74 4381 6 NPT NPT NNP cord-015021-pol2qm74 4381 7 levels level NNS cord-015021-pol2qm74 4381 8 in in IN cord-015021-pol2qm74 4381 9 the the DT cord-015021-pol2qm74 4381 10 supernatants supernatant NNS cord-015021-pol2qm74 4381 11 for for IN cord-015021-pol2qm74 4381 12 the the DT cord-015021-pol2qm74 4381 13 amount amount NN cord-015021-pol2qm74 4381 14 of of IN cord-015021-pol2qm74 4381 15 MO MO NNP cord-015021-pol2qm74 4381 16 stimulated stimulate VBN cord-015021-pol2qm74 4381 17 , , , cord-015021-pol2qm74 4381 18 the the DT cord-015021-pol2qm74 4381 19 NPT npt NN cord-015021-pol2qm74 4381 20 output output NN cord-015021-pol2qm74 4381 21 of of IN cord-015021-pol2qm74 4381 22 the the DT cord-015021-pol2qm74 4381 23 individual individual JJ cord-015021-pol2qm74 4381 24 cell cell NN cord-015021-pol2qm74 4381 25 was be VBD cord-015021-pol2qm74 4381 26 lower low JJR cord-015021-pol2qm74 4381 27 compared compare VBN cord-015021-pol2qm74 4381 28 to to IN cord-015021-pol2qm74 4381 29 MO MO NNP cord-015021-pol2qm74 4381 30 of of IN cord-015021-pol2qm74 4381 31 nontraumatized nontraumatize VBN cord-015021-pol2qm74 4381 32 individuals individual NNS cord-015021-pol2qm74 4381 33 . . . cord-015021-pol2qm74 4382 1 Interestingly interestingly RB cord-015021-pol2qm74 4382 2 there there EX cord-015021-pol2qm74 4382 3 was be VBD cord-015021-pol2qm74 4382 4 a a DT cord-015021-pol2qm74 4382 5 contrary contrary NN cord-015021-pol2qm74 4382 6 coarse coarse JJ cord-015021-pol2qm74 4382 7 in in IN cord-015021-pol2qm74 4382 8 the the DT cord-015021-pol2qm74 4382 9 cumulative cumulative JJ cord-015021-pol2qm74 4382 10 protein protein NN cord-015021-pol2qm74 4382 11 release release NN cord-015021-pol2qm74 4382 12 patterns pattern NNS cord-015021-pol2qm74 4382 13 of of IN cord-015021-pol2qm74 4383 1 IL-6 IL-6 NNP cord-015021-pol2qm74 4383 2 and and CC cord-015021-pol2qm74 4383 3 IFN-7 IFN-7 NNP cord-015021-pol2qm74 4383 4 in in IN cord-015021-pol2qm74 4383 5 mechanical mechanical JJ cord-015021-pol2qm74 4383 6 versus versus IN cord-015021-pol2qm74 4383 7 burn burn NN cord-015021-pol2qm74 4383 8 trauma trauma NN cord-015021-pol2qm74 4383 9 patients patient NNS cord-015021-pol2qm74 4383 10 . . . cord-015021-pol2qm74 4384 1 Wheras Wheras NNP cord-015021-pol2qm74 4384 2 in in IN cord-015021-pol2qm74 4384 3 burn burn NN cord-015021-pol2qm74 4384 4 patients patient NNS cord-015021-pol2qm74 4384 5 IFN IFN NNP cord-015021-pol2qm74 4384 6 - - HYPH cord-015021-pol2qm74 4384 7 y y NNP cord-015021-pol2qm74 4384 8 was be VBD cord-015021-pol2qm74 4384 9 decreased decrease VBN cord-015021-pol2qm74 4384 10 significantly significantly RB cord-015021-pol2qm74 4384 11 ( ( -LRB- cord-015021-pol2qm74 4384 12 16 16 CD cord-015021-pol2qm74 4384 13 + + SYM cord-015021-pol2qm74 4384 14 5 5 CD cord-015021-pol2qm74 4384 15 U u NN cord-015021-pol2qm74 4384 16 / / SYM cord-015021-pol2qm74 4384 17 ml ml NN cord-015021-pol2qm74 4384 18 ) ) -RRB- cord-015021-pol2qm74 4384 19 compared compare VBN cord-015021-pol2qm74 4384 20 to to IN cord-015021-pol2qm74 4384 21 controls control NNS cord-015021-pol2qm74 4384 22 ( ( -LRB- cord-015021-pol2qm74 4384 23 58 58 CD cord-015021-pol2qm74 4384 24 + + SYM cord-015021-pol2qm74 4384 25 6 6 CD cord-015021-pol2qm74 4384 26 U u NN cord-015021-pol2qm74 4384 27 / / SYM cord-015021-pol2qm74 4384 28 ml ml NN cord-015021-pol2qm74 4384 29 ) ) -RRB- cord-015021-pol2qm74 4384 30 as as RB cord-015021-pol2qm74 4384 31 well well RB cord-015021-pol2qm74 4384 32 as as IN cord-015021-pol2qm74 4384 33 mechanical mechanical JJ cord-015021-pol2qm74 4384 34 trauma trauma NN cord-015021-pol2qm74 4384 35 ( ( -LRB- cord-015021-pol2qm74 4384 36 59 59 CD cord-015021-pol2qm74 4384 37 + + SYM cord-015021-pol2qm74 4384 38 12 12 CD cord-015021-pol2qm74 4384 39 U u NN cord-015021-pol2qm74 4384 40 / / SYM cord-015021-pol2qm74 4384 41 ml ml NN cord-015021-pol2qm74 4384 42 ) ) -RRB- cord-015021-pol2qm74 4384 43 . . . cord-015021-pol2qm74 4385 1 IL-6 IL-6 NNP cord-015021-pol2qm74 4385 2 showed show VBD cord-015021-pol2qm74 4385 3 a a DT cord-015021-pol2qm74 4385 4 significant significant JJ cord-015021-pol2qm74 4385 5 suppression suppression NN cord-015021-pol2qm74 4385 6 following follow VBG cord-015021-pol2qm74 4385 7 mechanical mechanical JJ cord-015021-pol2qm74 4385 8 trauma trauma NN cord-015021-pol2qm74 4385 9 ( ( -LRB- cord-015021-pol2qm74 4385 10 662 662 CD cord-015021-pol2qm74 4385 11 + + SYM cord-015021-pol2qm74 4385 12 58 58 CD cord-015021-pol2qm74 4385 13 U u NN cord-015021-pol2qm74 4385 14 / / SYM cord-015021-pol2qm74 4385 15 ml ml NN cord-015021-pol2qm74 4385 16 ) ) -RRB- cord-015021-pol2qm74 4385 17 vs vs IN cord-015021-pol2qm74 4385 18 control control NN cord-015021-pol2qm74 4385 19 ( ( -LRB- cord-015021-pol2qm74 4385 20 1266 1266 CD cord-015021-pol2qm74 4385 21 + + SYM cord-015021-pol2qm74 4385 22 91 91 CD cord-015021-pol2qm74 4385 23 U u NN cord-015021-pol2qm74 4385 24 / / SYM cord-015021-pol2qm74 4385 25 ml ml NN cord-015021-pol2qm74 4385 26 ) ) -RRB- cord-015021-pol2qm74 4385 27 and and CC cord-015021-pol2qm74 4385 28 bum bum JJ cord-015021-pol2qm74 4385 29 patients patient NNS cord-015021-pol2qm74 4385 30 . . . cord-015021-pol2qm74 4386 1 The the DT cord-015021-pol2qm74 4386 2 rt~,NA rt~,na CD cord-015021-pol2qm74 4386 3 signal signal NN cord-015021-pol2qm74 4386 4 intensity intensity NN cord-015021-pol2qm74 4386 5 for for IN cord-015021-pol2qm74 4386 6 beth beth NNP cord-015021-pol2qm74 4386 7 eytokines eytokines NNP cord-015021-pol2qm74 4386 8 was be VBD cord-015021-pol2qm74 4386 9 in in IN cord-015021-pol2qm74 4386 10 concurrence concurrence NN cord-015021-pol2qm74 4386 11 with with IN cord-015021-pol2qm74 4386 12 the the DT cord-015021-pol2qm74 4386 13 protein protein NN cord-015021-pol2qm74 4386 14 release release NN cord-015021-pol2qm74 4386 15 in in IN cord-015021-pol2qm74 4386 16 more more JJR cord-015021-pol2qm74 4386 17 than than IN cord-015021-pol2qm74 4386 18 85 85 CD cord-015021-pol2qm74 4386 19 % % NN cord-015021-pol2qm74 4386 20 of of IN cord-015021-pol2qm74 4386 21 the the DT cord-015021-pol2qm74 4386 22 individual individual JJ cord-015021-pol2qm74 4386 23 patients patient NNS cord-015021-pol2qm74 4386 24 investigated investigate VBN cord-015021-pol2qm74 4386 25 . . . cord-015021-pol2qm74 4387 1 From from IN cord-015021-pol2qm74 4387 2 these these DT cord-015021-pol2qm74 4387 3 data datum NNS cord-015021-pol2qm74 4387 4 we -PRON- PRP cord-015021-pol2qm74 4387 5 can can MD cord-015021-pol2qm74 4387 6 conclude conclude VB cord-015021-pol2qm74 4387 7 that that IN cord-015021-pol2qm74 4387 8 the the DT cord-015021-pol2qm74 4387 9 inadequate inadequate JJ cord-015021-pol2qm74 4387 10 low low JJ cord-015021-pol2qm74 4387 11 NPT npt NN cord-015021-pol2qm74 4387 12 synthesis synthesis NN cord-015021-pol2qm74 4387 13 predominantly predominantly RB cord-015021-pol2qm74 4387 14 in in IN cord-015021-pol2qm74 4387 15 bum bum JJ cord-015021-pol2qm74 4387 16 patients patient NNS cord-015021-pol2qm74 4387 17 appears appear VBZ cord-015021-pol2qm74 4387 18 to to TO cord-015021-pol2qm74 4387 19 be be VB cord-015021-pol2qm74 4387 20 a a DT cord-015021-pol2qm74 4387 21 sign sign NN cord-015021-pol2qm74 4387 22 of of IN cord-015021-pol2qm74 4387 23 cellular cellular JJ cord-015021-pol2qm74 4387 24 immaturity immaturity NN cord-015021-pol2qm74 4387 25 and and CC cord-015021-pol2qm74 4387 26 is be VBZ cord-015021-pol2qm74 4387 27 probably probably RB cord-015021-pol2qm74 4387 28 partly partly RB cord-015021-pol2qm74 4387 29 due due JJ cord-015021-pol2qm74 4387 30 to to IN cord-015021-pol2qm74 4387 31 low low JJ cord-015021-pol2qm74 4387 32 T t NN cord-015021-pol2qm74 4387 33 - - HYPH cord-015021-pol2qm74 4387 34 cell cell NN cord-015021-pol2qm74 4387 35 IFNo IFNo NNS cord-015021-pol2qm74 4387 36 T t NN cord-015021-pol2qm74 4387 37 signals signal NNS cord-015021-pol2qm74 4387 38 . . . cord-015021-pol2qm74 4388 1 In in IN cord-015021-pol2qm74 4388 2 addition addition NN cord-015021-pol2qm74 4388 3 we -PRON- PRP cord-015021-pol2qm74 4388 4 could could MD cord-015021-pol2qm74 4388 5 state state VB cord-015021-pol2qm74 4388 6 that that IN cord-015021-pol2qm74 4388 7 the the DT cord-015021-pol2qm74 4388 8 quality quality NN cord-015021-pol2qm74 4388 9 of of IN cord-015021-pol2qm74 4388 10 trauma trauma NN cord-015021-pol2qm74 4388 11 is be VBZ cord-015021-pol2qm74 4388 12 apparently apparently RB cord-015021-pol2qm74 4388 13 responsible responsible JJ cord-015021-pol2qm74 4388 14 for for IN cord-015021-pol2qm74 4388 15 the the DT cord-015021-pol2qm74 4388 16 different different JJ cord-015021-pol2qm74 4388 17 synthesis synthesis NN cord-015021-pol2qm74 4388 18 patterns pattern NNS cord-015021-pol2qm74 4388 19 of of IN cord-015021-pol2qm74 4388 20 ] ] -RRB- cord-015021-pol2qm74 4388 21 L-6 L-6 NNP cord-015021-pol2qm74 4388 22 and and CC cord-015021-pol2qm74 4388 23 IFN IFN NNP cord-015021-pol2qm74 4388 24 - - HYPH cord-015021-pol2qm74 4388 25 q q NNP cord-015021-pol2qm74 4388 26 , , , cord-015021-pol2qm74 4388 27 . . . cord-015021-pol2qm74 4389 1 It -PRON- PRP cord-015021-pol2qm74 4389 2 has have VBZ cord-015021-pol2qm74 4389 3 been be VBN cord-015021-pol2qm74 4389 4 postulated postulate VBN cord-015021-pol2qm74 4389 5 that that IN cord-015021-pol2qm74 4389 6 bacterial bacterial JJ cord-015021-pol2qm74 4389 7 invasion invasion NN cord-015021-pol2qm74 4389 8 or or CC cord-015021-pol2qm74 4389 9 endotoxemia endotoxemia NN cord-015021-pol2qm74 4389 10 are be VBP cord-015021-pol2qm74 4389 11 necessary necessary JJ cord-015021-pol2qm74 4389 12 for for IN cord-015021-pol2qm74 4389 13 cytokine cytokine NN cord-015021-pol2qm74 4389 14 production production NN cord-015021-pol2qm74 4389 15 following follow VBG cord-015021-pol2qm74 4389 16 burn burn NN cord-015021-pol2qm74 4389 17 injury injury NN cord-015021-pol2qm74 4389 18 . . . cord-015021-pol2qm74 4390 1 We -PRON- PRP cord-015021-pol2qm74 4390 2 studied study VBD cord-015021-pol2qm74 4390 3 the the DT cord-015021-pol2qm74 4390 4 organ organ NN cord-015021-pol2qm74 4390 5 distribution distribution NN cord-015021-pol2qm74 4390 6 and and CC cord-015021-pol2qm74 4390 7 kinetics kinetics NN cord-015021-pol2qm74 4390 8 pattern pattern NN cord-015021-pol2qm74 4390 9 of of IN cord-015021-pol2qm74 4390 10 IL IL NNP cord-015021-pol2qm74 4390 11 - - HYPH cord-015021-pol2qm74 4390 12 fc~ fc~ NN cord-015021-pol2qm74 4390 13 ( ( -LRB- cord-015021-pol2qm74 4390 14 cell cell NN cord-015021-pol2qm74 4390 15 - - HYPH cord-015021-pol2qm74 4390 16 associated associate VBN cord-015021-pol2qm74 4390 17 IL-1 IL-1 NNP cord-015021-pol2qm74 4390 18 agonist agonist NN cord-015021-pol2qm74 4390 19 ) ) -RRB- cord-015021-pol2qm74 4390 20 in in IN cord-015021-pol2qm74 4390 21 eutrophic eutrophic JJ cord-015021-pol2qm74 4390 22 rats rat NNS cord-015021-pol2qm74 4390 23 subjected subject VBN cord-015021-pol2qm74 4390 24 to to IN cord-015021-pol2qm74 4390 25 either either CC cord-015021-pol2qm74 4390 26 20 20 CD cord-015021-pol2qm74 4390 27 % % NN cord-015021-pol2qm74 4390 28 TBSA TBSA NNP cord-015021-pol2qm74 4390 29 cutaneous cutaneous JJ cord-015021-pol2qm74 4390 30 scald scald NN cord-015021-pol2qm74 4390 31 injury injury NN cord-015021-pol2qm74 4390 32 ( ( -LRB- cord-015021-pol2qm74 4390 33 BI BI NNP cord-015021-pol2qm74 4390 34 ) ) -RRB- cord-015021-pol2qm74 4390 35 , , , cord-015021-pol2qm74 4390 36 muscle muscle NN cord-015021-pol2qm74 4390 37 scald scald NN cord-015021-pol2qm74 4390 38 injury injury NN cord-015021-pol2qm74 4390 39 of of IN cord-015021-pol2qm74 4390 40 equivalent equivalent JJ cord-015021-pol2qm74 4390 41 20 20 CD cord-015021-pol2qm74 4390 42 % % NN cord-015021-pol2qm74 4390 43 TBSA TBSA NNP cord-015021-pol2qm74 4390 44 ( ( -LRB- cord-015021-pol2qm74 4390 45 MBI MBI NNP cord-015021-pol2qm74 4390 46 ) ) -RRB- cord-015021-pol2qm74 4390 47 , , , cord-015021-pol2qm74 4390 48 sham sham NN cord-015021-pol2qm74 4390 49 muscle muscle NN cord-015021-pol2qm74 4390 50 bum bum NN cord-015021-pol2qm74 4390 51 ( ( -LRB- cord-015021-pol2qm74 4390 52 resection resection NN cord-015021-pol2qm74 4390 53 of of IN cord-015021-pol2qm74 4390 54 skin skin NN cord-015021-pol2qm74 4390 55 only only RB cord-015021-pol2qm74 4390 56 , , , cord-015021-pol2qm74 4390 57 up up IN cord-015021-pol2qm74 4390 58 to to TO cord-015021-pol2qm74 4390 59 20 20 CD cord-015021-pol2qm74 4390 60 % % NN cord-015021-pol2qm74 4390 61 TBSA TBSA NNP cord-015021-pol2qm74 4390 62 ) ) -RRB- cord-015021-pol2qm74 4390 63 ( ( -LRB- cord-015021-pol2qm74 4390 64 SMBI SMBI NNP cord-015021-pol2qm74 4390 65 ) ) -RRB- cord-015021-pol2qm74 4390 66 , , , cord-015021-pol2qm74 4390 67 and and CC cord-015021-pol2qm74 4390 68 sham sham JJ cord-015021-pol2qm74 4390 69 cutaneous cutaneous JJ cord-015021-pol2qm74 4390 70 burn burn NN cord-015021-pol2qm74 4390 71 ( ( -LRB- cord-015021-pol2qm74 4390 72 SBI SBI NNP cord-015021-pol2qm74 4390 73 ) ) -RRB- cord-015021-pol2qm74 4390 74 , , , cord-015021-pol2qm74 4390 75 followed follow VBN cord-015021-pol2qm74 4390 76 by by IN cord-015021-pol2qm74 4390 77 saline saline NN cord-015021-pol2qm74 4390 78 resuscitation resuscitation NN cord-015021-pol2qm74 4390 79 ( ( -LRB- cord-015021-pol2qm74 4390 80 15 15 CD cord-015021-pol2qm74 4390 81 mUkg mUkg NNP cord-015021-pol2qm74 4390 82 I.P. I.P. NNP cord-015021-pol2qm74 4390 83 ) ) -RRB- cord-015021-pol2qm74 4390 84 . . . cord-015021-pol2qm74 4391 1 Separate separate JJ cord-015021-pol2qm74 4391 2 rats rat NNS cord-015021-pol2qm74 4391 3 were be VBD cord-015021-pol2qm74 4391 4 infused infuse VBN cord-015021-pol2qm74 4391 5 with with IN cord-015021-pol2qm74 4391 6 15 15 CD cord-015021-pol2qm74 4391 7 mg mg NNP cord-015021-pol2qm74 4391 8 / / SYM cord-015021-pol2qm74 4391 9 kg kg NNP cord-015021-pol2qm74 4391 10 E.coli E.coli NNS cord-015021-pol2qm74 4391 11 0111 0111 CD cord-015021-pol2qm74 4391 12 : : : cord-015021-pol2qm74 4391 13 B4 B4 NNP cord-015021-pol2qm74 4391 14 LPS LPS NNP cord-015021-pol2qm74 4391 15 or or CC cord-015021-pol2qm74 4391 16 saline saline NN cord-015021-pol2qm74 4391 17 LV LV NNP cord-015021-pol2qm74 4391 18 . . . cord-015021-pol2qm74 4392 1 Unmanipulated unmanipulated JJ cord-015021-pol2qm74 4392 2 rats rat NNS cord-015021-pol2qm74 4392 3 were be VBD cord-015021-pol2qm74 4392 4 baseline baseline JJ cord-015021-pol2qm74 4392 5 normal normal JJ cord-015021-pol2qm74 4392 6 controls control NNS cord-015021-pol2qm74 4392 7 . . . cord-015021-pol2qm74 4393 1 Liver liver NN cord-015021-pol2qm74 4393 2 , , , cord-015021-pol2qm74 4393 3 lung lung NN cord-015021-pol2qm74 4393 4 , , , cord-015021-pol2qm74 4393 5 spleen spleen NNS cord-015021-pol2qm74 4393 6 , , , cord-015021-pol2qm74 4393 7 ileum ileum NN cord-015021-pol2qm74 4393 8 , , , cord-015021-pol2qm74 4393 9 thymus thymus NN cord-015021-pol2qm74 4393 10 , , , cord-015021-pol2qm74 4393 11 kidney kidney NN cord-015021-pol2qm74 4393 12 , , , cord-015021-pol2qm74 4393 13 skin skin NN cord-015021-pol2qm74 4393 14 , , , cord-015021-pol2qm74 4393 15 and and CC cord-015021-pol2qm74 4393 16 plasma plasma NN cord-015021-pol2qm74 4393 17 were be VBD cord-015021-pol2qm74 4393 18 harvested harvest VBN cord-015021-pol2qm74 4393 19 at at IN cord-015021-pol2qm74 4393 20 various various JJ cord-015021-pol2qm74 4393 21 time time NN cord-015021-pol2qm74 4393 22 - - HYPH cord-015021-pol2qm74 4393 23 points point NNS cord-015021-pol2qm74 4393 24 within within IN cord-015021-pol2qm74 4393 25 the the DT cord-015021-pol2qm74 4393 26 first first JJ cord-015021-pol2qm74 4393 27 24h 24h NNS cord-015021-pol2qm74 4393 28 . . . cord-015021-pol2qm74 4394 1 Tissues tissue NNS cord-015021-pol2qm74 4394 2 were be VBD cord-015021-pol2qm74 4394 3 frozen freeze VBN cord-015021-pol2qm74 4394 4 , , , cord-015021-pol2qm74 4394 5 weighed weigh VBN cord-015021-pol2qm74 4394 6 , , , cord-015021-pol2qm74 4394 7 homogenized homogenize VBN cord-015021-pol2qm74 4394 8 , , , cord-015021-pol2qm74 4394 9 the the DT cord-015021-pol2qm74 4394 10 homogenates homogenate NNS cord-015021-pol2qm74 4394 11 centrifuged centrifuge VBN cord-015021-pol2qm74 4394 12 and and CC cord-015021-pol2qm74 4394 13 the the DT cord-015021-pol2qm74 4394 14 supernates supernate NNS cord-015021-pol2qm74 4394 15 assayed assay VBN cord-015021-pol2qm74 4394 16 with with IN cord-015021-pol2qm74 4394 17 a a DT cord-015021-pol2qm74 4394 18 radioimmunoassay radioimmunoassay JJ cord-015021-pol2qm74 4394 19 specific specific JJ cord-015021-pol2qm74 4394 20 for for IN cord-015021-pol2qm74 4394 21 rat rat NN cord-015021-pol2qm74 4394 22 IL IL NNP cord-015021-pol2qm74 4394 23 - - HYPH cord-015021-pol2qm74 4394 24 l(z l(z NNP cord-015021-pol2qm74 4394 25 ( ( -LRB- cord-015021-pol2qm74 4394 26 detection detection NN cord-015021-pol2qm74 4394 27 limit limit NN cord-015021-pol2qm74 4394 28 150 150 CD cord-015021-pol2qm74 4394 29 pg pg NN cord-015021-pol2qm74 4394 30 / / SYM cord-015021-pol2qm74 4394 31 rnL rnL NNP cord-015021-pol2qm74 4394 32 ) ) -RRB- cord-015021-pol2qm74 4394 33 . . . cord-015021-pol2qm74 4395 1 IL IL NNP cord-015021-pol2qm74 4395 2 - - HYPH cord-015021-pol2qm74 4395 3 lc~ lc~ NNP cord-015021-pol2qm74 4395 4 was be VBD cord-015021-pol2qm74 4395 5 expressed express VBN cord-015021-pol2qm74 4395 6 as as IN cord-015021-pol2qm74 4395 7 ng ng NNP cord-015021-pol2qm74 4395 8 / / SYM cord-015021-pol2qm74 4395 9 g g NN cord-015021-pol2qm74 4395 10 weight weight NN cord-015021-pol2qm74 4395 11 + + CC cord-015021-pol2qm74 4395 12 SEM sem NN cord-015021-pol2qm74 4395 13 ( ( -LRB- cord-015021-pol2qm74 4395 14 lowest low JJS cord-015021-pol2qm74 4395 15 detectable detectable JJ cord-015021-pol2qm74 4395 16 amount amount NN cord-015021-pol2qm74 4395 17 1.5 1.5 CD cord-015021-pol2qm74 4395 18 ng ng NN cord-015021-pol2qm74 4395 19 / / SYM cord-015021-pol2qm74 4395 20 gWT gWT NNP cord-015021-pol2qm74 4395 21 ) ) -RRB- cord-015021-pol2qm74 4395 22 . . . cord-015021-pol2qm74 4396 1 IL IL NNP cord-015021-pol2qm74 4396 2 - - HYPH cord-015021-pol2qm74 4396 3 lo~ lo~ NNP cord-015021-pol2qm74 4396 4 was be VBD cord-015021-pol2qm74 4396 5 constitutively constitutively RB cord-015021-pol2qm74 4396 6 present present JJ cord-015021-pol2qm74 4396 7 only only RB cord-015021-pol2qm74 4396 8 in in IN cord-015021-pol2qm74 4396 9 the the DT cord-015021-pol2qm74 4396 10 skin skin NN cord-015021-pol2qm74 4396 11 ( ( -LRB- cord-015021-pol2qm74 4396 12 102 102 CD cord-015021-pol2qm74 4396 13 + + SYM cord-015021-pol2qm74 4396 14 16.4 16.4 CD cord-015021-pol2qm74 4396 15 ng ng NN cord-015021-pol2qm74 4396 16 / / SYM cord-015021-pol2qm74 4396 17 gWT gWT NNP cord-015021-pol2qm74 4396 18 ) ) -RRB- cord-015021-pol2qm74 4396 19 . . . cord-015021-pol2qm74 4397 1 Cutaneous cutaneous JJ cord-015021-pol2qm74 4397 2 burn burn NN cord-015021-pol2qm74 4397 3 and and CC cord-015021-pol2qm74 4397 4 sham sham JJ cord-015021-pol2qm74 4397 5 cutaneous cutaneous JJ cord-015021-pol2qm74 4397 6 bum bum NN cord-015021-pol2qm74 4397 7 induced induce VBN cord-015021-pol2qm74 4397 8 biphasic biphasic JJ cord-015021-pol2qm74 4397 9 elevations elevation NNS cord-015021-pol2qm74 4397 10 of of IN cord-015021-pol2qm74 4397 11 IL IL NNP cord-015021-pol2qm74 4397 12 - - HYPH cord-015021-pol2qm74 4397 13 lcc lcc NNP cord-015021-pol2qm74 4397 14 in in IN cord-015021-pol2qm74 4397 15 the the DT cord-015021-pol2qm74 4397 16 liver liver NN cord-015021-pol2qm74 4397 17 and and CC cord-015021-pol2qm74 4397 18 lung lung NN cord-015021-pol2qm74 4397 19 only only RB cord-015021-pol2qm74 4397 20 , , , cord-015021-pol2qm74 4397 21 with with IN cord-015021-pol2qm74 4397 22 maximal maximal JJ cord-015021-pol2qm74 4397 23 levels level NNS cord-015021-pol2qm74 4397 24 at at IN cord-015021-pol2qm74 4397 25 2.5h 2.5h CD cord-015021-pol2qm74 4397 26 ( ( -LRB- cord-015021-pol2qm74 4397 27 in in IN cord-015021-pol2qm74 4397 28 the the DT cord-015021-pol2qm74 4397 29 liver liver NN cord-015021-pol2qm74 4397 30 , , , cord-015021-pol2qm74 4397 31 BI BI NNP cord-015021-pol2qm74 4397 32 = = NFP cord-015021-pol2qm74 4398 1 16.5 16.5 NNP cord-015021-pol2qm74 4398 2 _ _ NNP cord-015021-pol2qm74 4398 3 + + SYM cord-015021-pol2qm74 4398 4 6.2 6.2 CD cord-015021-pol2qm74 4398 5 ng ng NN cord-015021-pol2qm74 4398 6 / / SYM cord-015021-pol2qm74 4398 7 gWT gWT NNS cord-015021-pol2qm74 4398 8 , , , cord-015021-pol2qm74 4398 9 SBI SBI NNP cord-015021-pol2qm74 4398 10 = = SYM cord-015021-pol2qm74 4399 1 1.7 1.7 CD cord-015021-pol2qm74 4399 2 + + SYM cord-015021-pol2qm74 4399 3 0.1 0.1 CD cord-015021-pol2qm74 4399 4 ng ng NN cord-015021-pol2qm74 4399 5 / / SYM cord-015021-pol2qm74 4399 6 gWT gWT NNS cord-015021-pol2qm74 4399 7 , , , cord-015021-pol2qm74 4399 8 p p NN cord-015021-pol2qm74 4399 9 _ _ NN cord-015021-pol2qm74 4399 10 < < XX cord-015021-pol2qm74 4399 11 0.05 0.05 CD cord-015021-pol2qm74 4399 12 ; ; : cord-015021-pol2qm74 4399 13 in in IN cord-015021-pol2qm74 4399 14 the the DT cord-015021-pol2qm74 4399 15 lung lung NN cord-015021-pol2qm74 4399 16 , , , cord-015021-pol2qm74 4399 17 BI BI NNP cord-015021-pol2qm74 4399 18 = = SYM cord-015021-pol2qm74 4399 19 10.3 10.3 CD cord-015021-pol2qm74 4399 20 + + SYM cord-015021-pol2qm74 4399 21 1.3 1.3 CD cord-015021-pol2qm74 4399 22 ng ng NN cord-015021-pol2qm74 4399 23 / / SYM cord-015021-pol2qm74 4399 24 gWT gWT NNS cord-015021-pol2qm74 4399 25 , , , cord-015021-pol2qm74 4399 26 SBI SBI NNP cord-015021-pol2qm74 4399 27 = = SYM cord-015021-pol2qm74 4399 28 1.9 1.9 CD cord-015021-pol2qm74 4399 29 + + SYM cord-015021-pol2qm74 4399 30 0.8 0.8 CD cord-015021-pol2qm74 4399 31 ng ng NN cord-015021-pol2qm74 4399 32 / / SYM cord-015021-pol2qm74 4399 33 gWT gWT NNS cord-015021-pol2qm74 4399 34 , , , cord-015021-pol2qm74 4399 35 p p NN cord-015021-pol2qm74 4399 36 - - HYPH cord-015021-pol2qm74 4399 37 < < XX cord-015021-pol2qm74 4399 38 0.002 0.002 CD cord-015021-pol2qm74 4399 39 ) ) -RRB- cord-015021-pol2qm74 4399 40 . . . cord-015021-pol2qm74 4400 1 Of of IN cord-015021-pol2qm74 4400 2 note note NN cord-015021-pol2qm74 4400 3 , , , cord-015021-pol2qm74 4400 4 both both CC cord-015021-pol2qm74 4400 5 BI BI NNP cord-015021-pol2qm74 4400 6 and and CC cord-015021-pol2qm74 4400 7 SBI SBI NNP cord-015021-pol2qm74 4400 8 rats rat NNS cord-015021-pol2qm74 4400 9 had have VBD cord-015021-pol2qm74 4400 10 detectable detectable JJ cord-015021-pol2qm74 4400 11 IL IL NNP cord-015021-pol2qm74 4400 12 - - HYPH cord-015021-pol2qm74 4400 13 I~ I~ NNP cord-015021-pol2qm74 4400 14 in in IN cord-015021-pol2qm74 4400 15 the the DT cord-015021-pol2qm74 4400 16 liver liver NN cord-015021-pol2qm74 4400 17 at at IN cord-015021-pol2qm74 4400 18 timepoint timepoint NN cord-015021-pol2qm74 4400 19 0 0 NFP cord-015021-pol2qm74 4400 20 already already RB cord-015021-pol2qm74 4400 21 ( ( -LRB- cord-015021-pol2qm74 4400 22 2 2 CD cord-015021-pol2qm74 4400 23 min min NN cord-015021-pol2qm74 4400 24 real real JJ cord-015021-pol2qm74 4400 25 - - HYPH cord-015021-pol2qm74 4400 26 time time NN cord-015021-pol2qm74 4400 27 ) ) -RRB- cord-015021-pol2qm74 4400 28 . . . cord-015021-pol2qm74 4401 1 These these DT cord-015021-pol2qm74 4401 2 levels level NNS cord-015021-pol2qm74 4401 3 increased increase VBD cord-015021-pol2qm74 4401 4 in in IN cord-015021-pol2qm74 4401 5 parallel parallel NN cord-015021-pol2qm74 4401 6 until until IN cord-015021-pol2qm74 4401 7 30 30 CD cord-015021-pol2qm74 4401 8 min min NN cord-015021-pol2qm74 4401 9 and and CC cord-015021-pol2qm74 4401 10 became become VBD cord-015021-pol2qm74 4401 11 eventually eventually RB cord-015021-pol2qm74 4401 12 different different JJ cord-015021-pol2qm74 4401 13 by by IN cord-015021-pol2qm74 4401 14 1 1 CD cord-015021-pol2qm74 4401 15 log log NN cord-015021-pol2qm74 4401 16 at at IN cord-015021-pol2qm74 4401 17 1 1 CD cord-015021-pol2qm74 4401 18 -2.5h -2.5h NN cord-015021-pol2qm74 4401 19 . . . cord-015021-pol2qm74 4402 1 All all DT cord-015021-pol2qm74 4402 2 other other JJ cord-015021-pol2qm74 4402 3 organs organ NNS cord-015021-pol2qm74 4402 4 as as RB cord-015021-pol2qm74 4402 5 well well RB cord-015021-pol2qm74 4402 6 as as IN cord-015021-pol2qm74 4402 7 plasma plasma NN cord-015021-pol2qm74 4402 8 were be VBD cord-015021-pol2qm74 4402 9 below below IN cord-015021-pol2qm74 4402 10 detection detection NN cord-015021-pol2qm74 4402 11 limits limit NNS cord-015021-pol2qm74 4402 12 . . . cord-015021-pol2qm74 4403 1 Muscle muscle NN cord-015021-pol2qm74 4403 2 burn burn VBP cord-015021-pol2qm74 4403 3 injury injury NN cord-015021-pol2qm74 4403 4 and and CC cord-015021-pol2qm74 4403 5 sham sham NN cord-015021-pol2qm74 4403 6 muscle muscle NN cord-015021-pol2qm74 4403 7 burn burn NN cord-015021-pol2qm74 4403 8 ( ( -LRB- cord-015021-pol2qm74 4403 9 skin skin NN cord-015021-pol2qm74 4403 10 resection resection NN cord-015021-pol2qm74 4403 11 ) ) -RRB- cord-015021-pol2qm74 4403 12 induced induce VBN cord-015021-pol2qm74 4403 13 similar similar JJ cord-015021-pol2qm74 4403 14 elevations elevation NNS cord-015021-pol2qm74 4403 15 of of IN cord-015021-pol2qm74 4403 16 IL-10~ il-10~ NN cord-015021-pol2qm74 4403 17 in in IN cord-015021-pol2qm74 4403 18 the the DT cord-015021-pol2qm74 4403 19 liver liver NN cord-015021-pol2qm74 4403 20 at at IN cord-015021-pol2qm74 4403 21 lh lh NNP cord-015021-pol2qm74 4403 22 , , , cord-015021-pol2qm74 4403 23 indistinguishable indistinguishable JJ cord-015021-pol2qm74 4403 24 from from IN cord-015021-pol2qm74 4403 25 each each DT cord-015021-pol2qm74 4403 26 other other JJ cord-015021-pol2qm74 4403 27 and and CC cord-015021-pol2qm74 4403 28 from from IN cord-015021-pol2qm74 4403 29 cutaneous cutaneous JJ cord-015021-pol2qm74 4403 30 burn burn NN cord-015021-pol2qm74 4403 31 . . . cord-015021-pol2qm74 4404 1 In in IN cord-015021-pol2qm74 4404 2 contrast contrast NN cord-015021-pol2qm74 4404 3 , , , cord-015021-pol2qm74 4404 4 LPS LPS NNP cord-015021-pol2qm74 4404 5 challenge challenge NN cord-015021-pol2qm74 4404 6 induced induce VBN cord-015021-pol2qm74 4404 7 dramatic dramatic JJ cord-015021-pol2qm74 4404 8 elevation elevation NN cord-015021-pol2qm74 4404 9 of of IN cord-015021-pol2qm74 4404 10 IL IL NNP cord-015021-pol2qm74 4404 11 - - HYPH cord-015021-pol2qm74 4404 12 t~ t~ NNP cord-015021-pol2qm74 4404 13 in in IN cord-015021-pol2qm74 4404 14 all all DT cord-015021-pol2qm74 4404 15 organs organ NNS cord-015021-pol2qm74 4404 16 tested test VBN cord-015021-pol2qm74 4404 17 except except IN cord-015021-pol2qm74 4404 18 for for IN cord-015021-pol2qm74 4404 19 the the DT cord-015021-pol2qm74 4404 20 kidney kidney NN cord-015021-pol2qm74 4404 21 ; ; : cord-015021-pol2qm74 4404 22 the the DT cord-015021-pol2qm74 4404 23 spleen spleen NN cord-015021-pol2qm74 4404 24 was be VBD cord-015021-pol2qm74 4404 25 the the DT cord-015021-pol2qm74 4404 26 most most RBS cord-015021-pol2qm74 4404 27 responsive responsive JJ cord-015021-pol2qm74 4404 28 organ organ NN cord-015021-pol2qm74 4404 29 to to IN cord-015021-pol2qm74 4404 30 LPS LPS NNP cord-015021-pol2qm74 4404 31 - - HYPH cord-015021-pol2qm74 4404 32 induced induce VBN cord-015021-pol2qm74 4404 33 IL IL NNP cord-015021-pol2qm74 4404 34 - - HYPH cord-015021-pol2qm74 4404 35 lo~ lo~ JJ cord-015021-pol2qm74 4404 36 production production NN cord-015021-pol2qm74 4404 37 . . . cord-015021-pol2qm74 4405 1 These these DT cord-015021-pol2qm74 4405 2 data datum NNS cord-015021-pol2qm74 4405 3 indicate indicate VBP cord-015021-pol2qm74 4405 4 that that IN cord-015021-pol2qm74 4405 5 thermal thermal JJ cord-015021-pol2qm74 4405 6 or or CC cord-015021-pol2qm74 4405 7 mechanical mechanical JJ cord-015021-pol2qm74 4405 8 injuries injury NNS cord-015021-pol2qm74 4405 9 induce induce VBP cord-015021-pol2qm74 4405 10 very very RB cord-015021-pol2qm74 4405 11 early early JJ cord-015021-pol2qm74 4405 12 and and CC cord-015021-pol2qm74 4405 13 organ organ NN cord-015021-pol2qm74 4405 14 specific specific JJ cord-015021-pol2qm74 4405 15 production production NN cord-015021-pol2qm74 4405 16 of of IN cord-015021-pol2qm74 4405 17 IL-1 IL-1 NNP cord-015021-pol2qm74 4405 18 c~ c~ NNP cord-015021-pol2qm74 4405 19 in in IN cord-015021-pol2qm74 4405 20 vivo vivo NN cord-015021-pol2qm74 4405 21 by by IN cord-015021-pol2qm74 4405 22 mechanisms mechanism NNS cord-015021-pol2qm74 4405 23 other other JJ cord-015021-pol2qm74 4405 24 than than IN cord-015021-pol2qm74 4405 25 endotoxemia endotoxemia NN cord-015021-pol2qm74 4405 26 . . . cord-015021-pol2qm74 4406 1 Injury injury NN cord-015021-pol2qm74 4406 2 - - HYPH cord-015021-pol2qm74 4406 3 induced induce VBN cord-015021-pol2qm74 4406 4 complement complement NN cord-015021-pol2qm74 4406 5 and and CC cord-015021-pol2qm74 4406 6 platelet platelet NN cord-015021-pol2qm74 4406 7 activation activation NN cord-015021-pol2qm74 4406 8 may may MD cord-015021-pol2qm74 4406 9 be be VB cord-015021-pol2qm74 4406 10 involved involve VBN cord-015021-pol2qm74 4406 11 as as RB cord-015021-pol2qm74 4406 12 well well RB cord-015021-pol2qm74 4406 13 as as IN cord-015021-pol2qm74 4406 14 the the DT cord-015021-pol2qm74 4406 15 neuro neuro NNP cord-015021-pol2qm74 4406 16 - - HYPH cord-015021-pol2qm74 4406 17 endocrine endocrine JJ cord-015021-pol2qm74 4406 18 axis axis NN cord-015021-pol2qm74 4406 19 , , , cord-015021-pol2qm74 4406 20 which which WDT cord-015021-pol2qm74 4406 21 may may MD cord-015021-pol2qm74 4406 22 explain explain VB cord-015021-pol2qm74 4406 23 the the DT cord-015021-pol2qm74 4406 24 low low JJ cord-015021-pol2qm74 4406 25 levels level NNS cord-015021-pol2qm74 4406 26 of of IN cord-015021-pol2qm74 4406 27 IL IL NNP cord-015021-pol2qm74 4406 28 - - HYPH cord-015021-pol2qm74 4406 29 lo~ lo~ NNP cord-015021-pol2qm74 4406 30 induction induction NN cord-015021-pol2qm74 4406 31 observed observe VBD cord-015021-pol2qm74 4406 32 in in IN cord-015021-pol2qm74 4406 33 all all DT cord-015021-pol2qm74 4406 34 rats rat NNS cord-015021-pol2qm74 4406 35 at at IN cord-015021-pol2qm74 4406 36 the the DT cord-015021-pol2qm74 4406 37 very very RB cord-015021-pol2qm74 4406 38 early early JJ cord-015021-pol2qm74 4406 39 time time NN cord-015021-pol2qm74 4406 40 - - HYPH cord-015021-pol2qm74 4406 41 points point NNS cord-015021-pol2qm74 4406 42 . . . cord-015021-pol2qm74 4407 1 Trauma Trauma NNP cord-015021-pol2qm74 4407 2 Services Services NNPS cord-015021-pol2qm74 4407 3 , , , cord-015021-pol2qm74 4407 4 Massachusetts Massachusetts NNP cord-015021-pol2qm74 4407 5 General General NNP cord-015021-pol2qm74 4407 6 Hospital Hospital NNP cord-015021-pol2qm74 4407 7 , , , cord-015021-pol2qm74 4407 8 and and CC cord-015021-pol2qm74 4407 9 Department Department NNP cord-015021-pol2qm74 4407 10 of of IN cord-015021-pol2qm74 4407 11 Surgery Surgery NNP cord-015021-pol2qm74 4407 12 , , , cord-015021-pol2qm74 4407 13 Harvard Harvard NNP cord-015021-pol2qm74 4407 14 Medical Medical NNP cord-015021-pol2qm74 4407 15 School School NNP cord-015021-pol2qm74 4407 16 . . . cord-015021-pol2qm74 4408 1 Fruit Fruit NNP cord-015021-pol2qm74 4408 2 , , , cord-015021-pol2qm74 4408 3 St St NNP cord-015021-pol2qm74 4408 4 , , , cord-015021-pol2qm74 4408 5 Boston Boston NNP cord-015021-pol2qm74 4408 6 , , , cord-015021-pol2qm74 4408 7 MA MA NNP cord-015021-pol2qm74 4408 8 02114 02114 CD cord-015021-pol2qm74 4408 9 . . . cord-015021-pol2qm74 4409 1 J. J. NNP cord-015021-pol2qm74 4409 2 F. F. NNP cord-015021-pol2qm74 4409 3 Schmand Schmand NNP cord-015021-pol2qm74 4409 4 * * NFP cord-015021-pol2qm74 4409 5 # # NN cord-015021-pol2qm74 4409 6 , , , cord-015021-pol2qm74 4409 7 A. A. NNP cord-015021-pol2qm74 4409 8 Ayala Ayala NNP cord-015021-pol2qm74 4409 9 * * NFP cord-015021-pol2qm74 4409 10 and and CC cord-015021-pol2qm74 4409 11 I. I. NNP cord-015021-pol2qm74 4409 12 H. H. NNP cord-015021-pol2qm74 4409 13 Chaudry Chaudry NNP cord-015021-pol2qm74 4410 1 * * NFP cord-015021-pol2qm74 4411 1 Studies study NNS cord-015021-pol2qm74 4411 2 indicate indicate VBP cord-015021-pol2qm74 4411 3 that that IN cord-015021-pol2qm74 4411 4 i.v i.v NNP cord-015021-pol2qm74 4411 5 . . . cord-015021-pol2qm74 4411 6 infusion infusion NN cord-015021-pol2qm74 4411 7 of of IN cord-015021-pol2qm74 4411 8 the the DT cord-015021-pol2qm74 4411 9 colloid colloid NN cord-015021-pol2qm74 4411 10 HES HES NNP cord-015021-pol2qm74 4411 11 in in IN cord-015021-pol2qm74 4411 12 normal normal JJ cord-015021-pol2qm74 4411 13 animals animal NNS cord-015021-pol2qm74 4411 14 does do VBZ cord-015021-pol2qm74 4411 15 not not RB cord-015021-pol2qm74 4411 16 adversely adversely RB cord-015021-pol2qm74 4411 17 affect affect VB cord-015021-pol2qm74 4411 18 non non JJ cord-015021-pol2qm74 4411 19 - - JJ cord-015021-pol2qm74 4411 20 specific specific JJ cord-015021-pol2qm74 4411 21 immunity immunity NN cord-015021-pol2qm74 4411 22 . . . cord-015021-pol2qm74 4412 1 It -PRON- PRP cord-015021-pol2qm74 4412 2 remains remain VBZ cord-015021-pol2qm74 4412 3 unknown unknown JJ cord-015021-pol2qm74 4412 4 , , , cord-015021-pol2qm74 4412 5 however however RB cord-015021-pol2qm74 4412 6 , , , cord-015021-pol2qm74 4413 1 if if IN cord-015021-pol2qm74 4413 2 lIES lies JJ cord-015021-pol2qm74 4413 3 affects affect VBZ cord-015021-pol2qm74 4413 4 cell cell NN cord-015021-pol2qm74 4413 5 mediated mediate VBN cord-015021-pol2qm74 4413 6 , , , cord-015021-pol2qm74 4413 7 specific specific JJ cord-015021-pol2qm74 4413 8 immune immune JJ cord-015021-pol2qm74 4413 9 functions function NNS cord-015021-pol2qm74 4413 10 after after IN cord-015021-pol2qm74 4413 11 trauma trauma NN cord-015021-pol2qm74 4413 12 and and CC cord-015021-pol2qm74 4413 13 hemorrhage hemorrhage NN cord-015021-pol2qm74 4413 14 ( ( -LRB- cord-015021-pol2qm74 4413 15 hem hem NNP cord-015021-pol2qm74 4413 16 ) ) -RRB- cord-015021-pol2qm74 4413 17 . . . cord-015021-pol2qm74 4414 1 To to TO cord-015021-pol2qm74 4414 2 study study VB cord-015021-pol2qm74 4414 3 this this DT cord-015021-pol2qm74 4414 4 , , , cord-015021-pol2qm74 4414 5 non non JJ cord-015021-pol2qm74 4414 6 - - JJ cord-015021-pol2qm74 4414 7 heparinized heparinized JJ cord-015021-pol2qm74 4414 8 C3H C3H NNP cord-015021-pol2qm74 4414 9 / / SYM cord-015021-pol2qm74 4414 10 HeN hen JJ cord-015021-pol2qm74 4414 11 mice mouse NNS cord-015021-pol2qm74 4414 12 underwent undergo VBD cord-015021-pol2qm74 4414 13 midline midline JJ cord-015021-pol2qm74 4414 14 laparotomy laparotomy NN cord-015021-pol2qm74 4414 15 to to TO cord-015021-pol2qm74 4414 16 induce induce VB cord-015021-pol2qm74 4414 17 trauma trauma NN cord-015021-pol2qm74 4414 18 and and CC cord-015021-pol2qm74 4414 19 were be VBD cord-015021-pol2qm74 4414 20 then then RB cord-015021-pol2qm74 4414 21 bled bleed VBN cord-015021-pol2qm74 4414 22 to to IN cord-015021-pol2qm74 4414 23 and and CC cord-015021-pol2qm74 4414 24 maintained maintain VBD cord-015021-pol2qm74 4414 25 at at IN cord-015021-pol2qm74 4414 26 a a DT cord-015021-pol2qm74 4414 27 BP BP NNP cord-015021-pol2qm74 4414 28 of of IN cord-015021-pol2qm74 4414 29 40 40 CD cord-015021-pol2qm74 4414 30 mmI mmI NNP cord-015021-pol2qm74 4414 31 - - HYPH cord-015021-pol2qm74 4414 32 Ig Ig NNP cord-015021-pol2qm74 4414 33 for for IN cord-015021-pol2qm74 4414 34 60 60 CD cord-015021-pol2qm74 4414 35 rain rain NN cord-015021-pol2qm74 4414 36 . . . cord-015021-pol2qm74 4415 1 The the DT cord-015021-pol2qm74 4415 2 animals animal NNS cord-015021-pol2qm74 4415 3 were be VBD cord-015021-pol2qm74 4415 4 then then RB cord-015021-pol2qm74 4415 5 resuscitated resuscitate VBN cord-015021-pol2qm74 4415 6 with with IN cord-015021-pol2qm74 4415 7 either either DT cord-015021-pol2qm74 4415 8 4 4 CD cord-015021-pol2qm74 4415 9 times time NNS cord-015021-pol2qm74 4415 10 ( ( -LRB- cord-015021-pol2qm74 4416 1 x x LS cord-015021-pol2qm74 4416 2 ) ) -RRB- cord-015021-pol2qm74 4416 3 the the DT cord-015021-pol2qm74 4416 4 shed shed JJ cord-015021-pol2qm74 4416 5 blood blood NN cord-015021-pol2qm74 4416 6 vohune vohune NN cord-015021-pol2qm74 4416 7 as as IN cord-015021-pol2qm74 4416 8 lactated lactated NNP cord-015021-pol2qm74 4416 9 Ringer Ringer NNP cord-015021-pol2qm74 4416 10 's 's POS cord-015021-pol2qm74 4416 11 solution solution NN cord-015021-pol2qm74 4416 12 ( ( -LRB- cord-015021-pol2qm74 4416 13 LRS LRS NNP cord-015021-pol2qm74 4416 14 ) ) -RRB- cord-015021-pol2qm74 4416 15 or or CC cord-015021-pol2qm74 4416 16 2x 2x CD cord-015021-pol2qm74 4416 17 LRS LRS NNP cord-015021-pol2qm74 4416 18 + + SYM cord-015021-pol2qm74 4416 19 lx lx NNP cord-015021-pol2qm74 4416 20 6 6 CD cord-015021-pol2qm74 4416 21 % % NN cord-015021-pol2qm74 4416 22 lIES lie NNS cord-015021-pol2qm74 4416 23 . . . cord-015021-pol2qm74 4417 1 Sham sham JJ cord-015021-pol2qm74 4417 2 mice mouse NNS cord-015021-pol2qm74 4417 3 were be VBD cord-015021-pol2qm74 4417 4 neither neither CC cord-015021-pol2qm74 4417 5 hemorrhaged hemorrhage VBN cord-015021-pol2qm74 4417 6 nor nor CC cord-015021-pol2qm74 4417 7 resuscitated resuscitate VBN cord-015021-pol2qm74 4417 8 . . . cord-015021-pol2qm74 4418 1 At at IN cord-015021-pol2qm74 4418 2 2 2 CD cord-015021-pol2qm74 4418 3 or or CC cord-015021-pol2qm74 4418 4 24 24 CD cord-015021-pol2qm74 4418 5 hours hour NNS cord-015021-pol2qm74 4418 6 post post NN cord-015021-pol2qm74 4418 7 hem hem NNP cord-015021-pol2qm74 4418 8 serum serum NN cord-015021-pol2qm74 4418 9 , , , cord-015021-pol2qm74 4418 10 peritoneal peritoneal JJ cord-015021-pol2qm74 4418 11 ( ( -LRB- cord-015021-pol2qm74 4418 12 PM~ PM~ NNP cord-015021-pol2qm74 4418 13 ) ) -RRB- cord-015021-pol2qm74 4418 14 and and CC cord-015021-pol2qm74 4418 15 splenic splenic JJ cord-015021-pol2qm74 4418 16 macrophages macrophage NNS cord-015021-pol2qm74 4418 17 ( ( -LRB- cord-015021-pol2qm74 4418 18 SM~ SM~ NNP cord-015021-pol2qm74 4418 19 ) ) -RRB- cord-015021-pol2qm74 4418 20 were be VBD cord-015021-pol2qm74 4418 21 obtained obtain VBN cord-015021-pol2qm74 4418 22 . . . cord-015021-pol2qm74 4419 1 Bioassayes Bioassayes NNP cord-015021-pol2qm74 4419 2 were be VBD cord-015021-pol2qm74 4419 3 employed employ VBN cord-015021-pol2qm74 4419 4 to to TO cord-015021-pol2qm74 4419 5 assess assess VB cord-015021-pol2qm74 4419 6 the the DT cord-015021-pol2qm74 4419 7 levels level NNS cord-015021-pol2qm74 4419 8 of of IN cord-015021-pol2qm74 4419 9 II II NNP cord-015021-pol2qm74 4419 10 - - HYPH cord-015021-pol2qm74 4419 11 l l NNP cord-015021-pol2qm74 4419 12 , , , cord-015021-pol2qm74 4420 1 IL-6 IL-6 NNP cord-015021-pol2qm74 4420 2 ( ( -LRB- cord-015021-pol2qm74 4420 3 Alternatively alternatively RB cord-015021-pol2qm74 4420 4 PMqb PMqb NNP cord-015021-pol2qm74 4420 5 showed show VBD cord-015021-pol2qm74 4420 6 no no DT cord-015021-pol2qm74 4420 7 differences difference NNS cord-015021-pol2qm74 4420 8 in in IN cord-015021-pol2qm74 4420 9 IL-1 IL-1 NNP cord-015021-pol2qm74 4420 10 release release NN cord-015021-pol2qm74 4420 11 between between IN cord-015021-pol2qm74 4420 12 all all DT cord-015021-pol2qm74 4420 13 groups group NNS cord-015021-pol2qm74 4420 14 at at IN cord-015021-pol2qm74 4420 15 2 2 CD cord-015021-pol2qm74 4420 16 and and CC cord-015021-pol2qm74 4420 17 24h 24h NNS cord-015021-pol2qm74 4420 18 , , , cord-015021-pol2qm74 4420 19 while while IN cord-015021-pol2qm74 4420 20 SM~ SM~ NNP cord-015021-pol2qm74 4420 21 from from IN cord-015021-pol2qm74 4420 22 the the DT cord-015021-pol2qm74 4420 23 LRS LRS NNP cord-015021-pol2qm74 4420 24 + + CC cord-015021-pol2qm74 4420 25 HEN HEN NNP cord-015021-pol2qm74 4420 26 group group NN cord-015021-pol2qm74 4420 27 showed show VBD cord-015021-pol2qm74 4420 28 a a DT cord-015021-pol2qm74 4420 29 depression depression NN cord-015021-pol2qm74 4420 30 at at IN cord-015021-pol2qm74 4420 31 24h 24h NNS cord-015021-pol2qm74 4420 32 . . . cord-015021-pol2qm74 4421 1 TNF tnf NN cord-015021-pol2qm74 4421 2 production production NN cord-015021-pol2qm74 4421 3 by by IN cord-015021-pol2qm74 4421 4 PM~ PM~ NNP cord-015021-pol2qm74 4421 5 was be VBD cord-015021-pol2qm74 4421 6 depressed depressed JJ cord-015021-pol2qm74 4421 7 in in IN cord-015021-pol2qm74 4421 8 all all DT cord-015021-pol2qm74 4421 9 groups group NNS cord-015021-pol2qm74 4421 10 at at IN cord-015021-pol2qm74 4421 11 2h 2h CD cord-015021-pol2qm74 4421 12 and and CC cord-015021-pol2qm74 4421 13 remained remain VBD cord-015021-pol2qm74 4421 14 so so RB cord-015021-pol2qm74 4421 15 in in IN cord-015021-pol2qm74 4421 16 the the DT cord-015021-pol2qm74 4421 17 LRS LRS NNP cord-015021-pol2qm74 4421 18 + + SYM cord-015021-pol2qm74 4421 19 HES HES NNP cord-015021-pol2qm74 4421 20 group group NN cord-015021-pol2qm74 4421 21 at at IN cord-015021-pol2qm74 4421 22 24h 24h NNS cord-015021-pol2qm74 4421 23 . . . cord-015021-pol2qm74 4422 1 SM SM NNP cord-015021-pol2qm74 4423 1 ~b ~b NNP cord-015021-pol2qm74 4423 2 showed show VBD cord-015021-pol2qm74 4423 3 decreased decrease VBD cord-015021-pol2qm74 4423 4 TNF TNF NNP cord-015021-pol2qm74 4423 5 release release NN cord-015021-pol2qm74 4423 6 values value NNS cord-015021-pol2qm74 4423 7 in in IN cord-015021-pol2qm74 4423 8 both both CC cord-015021-pol2qm74 4423 9 hem hem NNP cord-015021-pol2qm74 4423 10 groups group NNS cord-015021-pol2qm74 4423 11 at at IN cord-015021-pol2qm74 4423 12 2 2 CD cord-015021-pol2qm74 4423 13 and and CC cord-015021-pol2qm74 4423 14 24h 24h NNS cord-015021-pol2qm74 4423 15 . . . cord-015021-pol2qm74 4424 1 In in IN cord-015021-pol2qm74 4424 2 summary summary NN cord-015021-pol2qm74 4424 3 , , , cord-015021-pol2qm74 4424 4 the the DT cord-015021-pol2qm74 4424 5 levels level NNS cord-015021-pol2qm74 4424 6 of of IN cord-015021-pol2qm74 4424 7 inflammatory inflammatory JJ cord-015021-pol2qm74 4424 8 cytokines cytokine NNS cord-015021-pol2qm74 4424 9 ( ( -LRB- cord-015021-pol2qm74 4424 10 particularly particularly RB cord-015021-pol2qm74 4424 11 the the DT cord-015021-pol2qm74 4424 12 values value NNS cord-015021-pol2qm74 4424 13 of of IN cord-015021-pol2qm74 4424 14 circulating circulate VBG cord-015021-pol2qm74 4424 15 IL-6 IL-6 NNP cord-015021-pol2qm74 4424 16 ) ) -RRB- cord-015021-pol2qm74 4424 17 after after IN cord-015021-pol2qm74 4424 18 trauma trauma NN cord-015021-pol2qm74 4424 19 / / SYM cord-015021-pol2qm74 4424 20 hem hem NNS cord-015021-pol2qm74 4424 21 are be VBP cord-015021-pol2qm74 4424 22 positively positively RB cord-015021-pol2qm74 4424 23 influenced influence VBN cord-015021-pol2qm74 4424 24 by by IN cord-015021-pol2qm74 4424 25 the the DT cord-015021-pol2qm74 4424 26 administration administration NN cord-015021-pol2qm74 4424 27 of of IN cord-015021-pol2qm74 4424 28 HES HES NNP cord-015021-pol2qm74 4424 29 . . . cord-015021-pol2qm74 4425 1 This this DT cord-015021-pol2qm74 4425 2 might may MD cord-015021-pol2qm74 4425 3 be be VB cord-015021-pol2qm74 4425 4 due due JJ cord-015021-pol2qm74 4425 5 to to IN cord-015021-pol2qm74 4425 6 a a DT cord-015021-pol2qm74 4425 7 protective protective JJ cord-015021-pol2qm74 4425 8 effect effect NN cord-015021-pol2qm74 4425 9 on on IN cord-015021-pol2qm74 4425 10 PMqb PMqb NNP cord-015021-pol2qm74 4425 11 and and CC cord-015021-pol2qm74 4425 12 SM~ SM~ NNP cord-015021-pol2qm74 4425 13 , , , cord-015021-pol2qm74 4425 14 but but CC cord-015021-pol2qm74 4425 15 also also RB cord-015021-pol2qm74 4425 16 on on IN cord-015021-pol2qm74 4425 17 other other JJ cord-015021-pol2qm74 4425 18 cytokine cytokine NN cord-015021-pol2qm74 4425 19 producing produce VBG cord-015021-pol2qm74 4425 20 cells cell NNS cord-015021-pol2qm74 4425 21 , , , cord-015021-pol2qm74 4425 22 e.g. e.g. RB cord-015021-pol2qm74 4425 23 Kupffer Kupffer NNP cord-015021-pol2qm74 4425 24 ceils ceil NNS cord-015021-pol2qm74 4425 25 . . . cord-015021-pol2qm74 4426 1 We -PRON- PRP cord-015021-pol2qm74 4426 2 conclude conclude VBP cord-015021-pol2qm74 4426 3 that that IN cord-015021-pol2qm74 4426 4 HES HES NNP cord-015021-pol2qm74 4426 5 is be VBZ cord-015021-pol2qm74 4426 6 not not RB cord-015021-pol2qm74 4426 7 only only RB cord-015021-pol2qm74 4426 8 a a DT cord-015021-pol2qm74 4426 9 safe safe JJ cord-015021-pol2qm74 4426 10 , , , cord-015021-pol2qm74 4426 11 but but CC cord-015021-pol2qm74 4426 12 also also RB cord-015021-pol2qm74 4426 13 beneficial beneficial JJ cord-015021-pol2qm74 4426 14 agent agent NN cord-015021-pol2qm74 4426 15 in in IN cord-015021-pol2qm74 4426 16 the the DT cord-015021-pol2qm74 4426 17 resuscitation resuscitation NN cord-015021-pol2qm74 4426 18 of of IN cord-015021-pol2qm74 4426 19 patients patient NNS cord-015021-pol2qm74 4427 1 atler atler NNP cord-015021-pol2qm74 4427 2 trauma trauma NNP cord-015021-pol2qm74 4427 3 / / SYM cord-015021-pol2qm74 4427 4 bemorrhagic bemorrhagic NN cord-015021-pol2qm74 4427 5 shock shock NN cord-015021-pol2qm74 4427 6 . . . cord-015021-pol2qm74 4428 1 This this DT cord-015021-pol2qm74 4428 2 study study NN cord-015021-pol2qm74 4428 3 investigated investigate VBD cord-015021-pol2qm74 4428 4 endotoxemia endotoxemia NN cord-015021-pol2qm74 4428 5 and and CC cord-015021-pol2qm74 4428 6 consecutlve consecutlve NN cord-015021-pol2qm74 4428 7 immune immune JJ cord-015021-pol2qm74 4428 8 response response NN cord-015021-pol2qm74 4428 9 in in IN cord-015021-pol2qm74 4428 10 39 39 CD cord-015021-pol2qm74 4428 11 patients patient NNS cord-015021-pol2qm74 4428 12 with with IN cord-015021-pol2qm74 4428 13 multiple multiple JJ cord-015021-pol2qm74 4428 14 trauma trauma NN cord-015021-pol2qm74 4428 15 ( ( -LRB- cord-015021-pol2qm74 4428 16 median median JJ cord-015021-pol2qm74 4428 17 Injury injury NN cord-015021-pol2qm74 4428 18 Severity severity NN cord-015021-pol2qm74 4428 19 Score score NN cord-015021-pol2qm74 4428 20 = = SYM cord-015021-pol2qm74 4428 21 20,5 20,5 CD cord-015021-pol2qm74 4428 22 ) ) -RRB- cord-015021-pol2qm74 4428 23 . . . cord-015021-pol2qm74 4429 1 Blood blood NN cord-015021-pol2qm74 4429 2 samples.were samples.were RB cord-015021-pol2qm74 4429 3 collected collect VBN cord-015021-pol2qm74 4429 4 shortly shortly RB cord-015021-pol2qm74 4429 5 after after IN cord-015021-pol2qm74 4429 6 injury injury NN cord-015021-pol2qm74 4429 7 and and CC cord-015021-pol2qm74 4429 8 after after IN cord-015021-pol2qm74 4429 9 0,5 0,5 CD cord-015021-pol2qm74 4429 10 , , , cord-015021-pol2qm74 4429 11 1 1 CD cord-015021-pol2qm74 4429 12 , , , cord-015021-pol2qm74 4429 13 3 3 CD cord-015021-pol2qm74 4429 14 , , , cord-015021-pol2qm74 4429 15 S S NNP cord-015021-pol2qm74 4429 16 and and CC cord-015021-pol2qm74 4429 17 l0 l0 NNP cord-015021-pol2qm74 4429 18 days day NNS cord-015021-pol2qm74 4429 19 . . . cord-015021-pol2qm74 4430 1 Endotoxin endotoxin NN cord-015021-pol2qm74 4430 2 was be VBD cord-015021-pol2qm74 4430 3 measured measure VBN cord-015021-pol2qm74 4430 4 with with IN cord-015021-pol2qm74 4430 5 limulus limulus NNP cord-015021-pol2qm74 4430 6 - - HYPH cord-015021-pol2qm74 4430 7 amebocyte amebocyte NN cord-015021-pol2qm74 4430 8 lysate lysate NN cord-015021-pol2qm74 4430 9 test test NN cord-015021-pol2qm74 4430 10 and and CC cord-015021-pol2qm74 4430 11 the the DT cord-015021-pol2qm74 4430 12 specific specific JJ cord-015021-pol2qm74 4430 13 antibody antibody NN cord-015021-pol2qm74 4430 14 content content NN cord-015021-pol2qm74 4430 15 ( ( -LRB- cord-015021-pol2qm74 4430 16 SAC SAC NNP cord-015021-pol2qm74 4430 17 ) ) -RRB- cord-015021-pol2qm74 4430 18 against against IN cord-015021-pol2qm74 4430 19 endotoxins endotoxin NNS cord-015021-pol2qm74 4430 20 of of IN cord-015021-pol2qm74 4430 21 the the DT cord-015021-pol2qm74 4430 22 classes class NNS cord-015021-pol2qm74 4430 23 IgG IgG NNP cord-015021-pol2qm74 4430 24 , , , cord-015021-pol2qm74 4430 25 IgM IgM NNP cord-015021-pol2qm74 4430 26 and and CC cord-015021-pol2qm74 4430 27 lgA lgA NNP cord-015021-pol2qm74 4430 28 by by IN cord-015021-pol2qm74 4430 29 ELISA ELISA NNP cord-015021-pol2qm74 4430 30 - - HYPH cord-015021-pol2qm74 4430 31 technique technique NN cord-015021-pol2qm74 4430 32 . . . cord-015021-pol2qm74 4431 1 Five five CD cord-015021-pol2qm74 4431 2 antigens antigen NNS cord-015021-pol2qm74 4431 3 were be VBD cord-015021-pol2qm74 4431 4 used use VBN cord-015021-pol2qm74 4431 5 : : : cord-015021-pol2qm74 4431 6 Lipopolysaccaride Lipopolysaccaride NNP cord-015021-pol2qm74 4431 7 ( ( -LRB- cord-015021-pol2qm74 4431 8 LPS LPS NNP cord-015021-pol2qm74 4431 9 ) ) -RRB- cord-015021-pol2qm74 4431 10 of of IN cord-015021-pol2qm74 4431 11 E.coli E.coli NNS cord-015021-pol2qm74 4431 12 ( ( -LRB- cord-015021-pol2qm74 4431 13 EC EC NNP cord-015021-pol2qm74 4431 14 ) ) -RRB- cord-015021-pol2qm74 4431 15 , , , cord-015021-pol2qm74 4431 16 Lipid Lipid NNP cord-015021-pol2qm74 4431 17 A a NN cord-015021-pol2qm74 4431 18 of of IN cord-015021-pol2qm74 4431 19 E.coli E.coli NNS cord-015021-pol2qm74 4431 20 ( ( -LRB- cord-015021-pol2qm74 4431 21 LA LA NNP cord-015021-pol2qm74 4431 22 ) ) -RRB- cord-015021-pol2qm74 4431 23 , , , cord-015021-pol2qm74 4431 24 LPS LPS NNP cord-015021-pol2qm74 4431 25 of of IN cord-015021-pol2qm74 4431 26 Pseudomonas Pseudomonas NNP cord-015021-pol2qm74 4431 27 aerog aerog VBZ cord-015021-pol2qm74 4431 28 . . . cord-015021-pol2qm74 4432 1 ( ( -LRB- cord-015021-pol2qm74 4432 2 PA PA NNP cord-015021-pol2qm74 4432 3 ) ) -RRB- cord-015021-pol2qm74 4432 4 , , , cord-015021-pol2qm74 4432 5 LPS LPS NNP cord-015021-pol2qm74 4432 6 of of IN cord-015021-pol2qm74 4432 7 Vibrin Vibrin NNP cord-015021-pol2qm74 4432 8 cholerae cholerae NN cord-015021-pol2qm74 4432 9 ( ( -LRB- cord-015021-pol2qm74 4432 10 VC VC NNP cord-015021-pol2qm74 4432 11 ) ) -RRB- cord-015021-pol2qm74 4432 12 and and CC cord-015021-pol2qm74 4432 13 cX cX NNP cord-015021-pol2qm74 4432 14 - - HYPH cord-015021-pol2qm74 4432 15 Hemolysin Hemolysin NNP cord-015021-pol2qm74 4432 16 of of IN cord-015021-pol2qm74 4432 17 Staphylococcus Staphylococcus NNP cord-015021-pol2qm74 4432 18 anreus anreu NNS cord-015021-pol2qm74 4432 19 ( ( -LRB- cord-015021-pol2qm74 4432 20 OtH OtH NNP cord-015021-pol2qm74 4432 21 ) ) -RRB- cord-015021-pol2qm74 4432 22 . . . cord-015021-pol2qm74 4433 1 A a DT cord-015021-pol2qm74 4433 2 nephelometer nephelometer NN cord-015021-pol2qm74 4433 3 indicated indicate VBD cord-015021-pol2qm74 4433 4 the the DT cord-015021-pol2qm74 4433 5 total total JJ cord-015021-pol2qm74 4433 6 concentrations concentration NNS cord-015021-pol2qm74 4433 7 of of IN cord-015021-pol2qm74 4433 8 IgG IgG NNP cord-015021-pol2qm74 4433 9 , , , cord-015021-pol2qm74 4433 10 IgM IgM NNP cord-015021-pol2qm74 4433 11 and and CC cord-015021-pol2qm74 4434 1 IgA. IgA. NNP cord-015021-pol2qm74 4435 1 Differences difference NNS cord-015021-pol2qm74 4435 2 were be VBD cord-015021-pol2qm74 4435 3 checked check VBN cord-015021-pol2qm74 4435 4 with with IN cord-015021-pol2qm74 4435 5 Wilcoxon Wilcoxon NNP cord-015021-pol2qm74 4435 6 - - HYPH cord-015021-pol2qm74 4435 7 test test NN cord-015021-pol2qm74 4435 8 and and CC cord-015021-pol2qm74 4435 9 p<0,0S p<0,0S NNP cord-015021-pol2qm74 4435 10 was be VBD cord-015021-pol2qm74 4435 11 considered consider VBN cord-015021-pol2qm74 4435 12 significant significant JJ cord-015021-pol2qm74 4435 13 . . . cord-015021-pol2qm74 4436 1 Cross cross NN cord-015021-pol2qm74 4436 2 - - NN cord-015021-pol2qm74 4436 3 reactivity reactivity NN cord-015021-pol2qm74 4436 4 was be VBD cord-015021-pol2qm74 4436 5 calculated calculate VBN cord-015021-pol2qm74 4436 6 with with IN cord-015021-pol2qm74 4436 7 rank rank NN cord-015021-pol2qm74 4436 8 correlation correlation NN cord-015021-pol2qm74 4436 9 coefficients coefficient NNS cord-015021-pol2qm74 4436 10 . . . cord-015021-pol2qm74 4437 1 Results result NNS cord-015021-pol2qm74 4437 2 : : : cord-015021-pol2qm74 4438 1 Endotoxemia Endotoxemia NNP cord-015021-pol2qm74 4438 2 peaked peak VBD cord-015021-pol2qm74 4438 3 shortly shortly RB cord-015021-pol2qm74 4438 4 after after IN cord-015021-pol2qm74 4438 5 injury injury NN cord-015021-pol2qm74 4438 6 ( ( -LRB- cord-015021-pol2qm74 4438 7 0 0 CD cord-015021-pol2qm74 4438 8 - - HYPH cord-015021-pol2qm74 4438 9 3h 3h CD cord-015021-pol2qm74 4438 10 ) ) -RRB- cord-015021-pol2qm74 4438 11 at at IN cord-015021-pol2qm74 4438 12 0,425 0,425 CD cord-015021-pol2qm74 4438 13 EkI EkI NNP cord-015021-pol2qm74 4438 14 / / , cord-015021-pol2qm74 4438 15 ml ml NN cord-015021-pol2qm74 4438 16 ( ( -LRB- cord-015021-pol2qm74 4438 17 median median NN cord-015021-pol2qm74 4438 18 ) ) -RRB- cord-015021-pol2qm74 4438 19 , , , cord-015021-pol2qm74 4438 20 decreased decrease VBD cord-015021-pol2qm74 4438 21 thereafter thereafter RB cord-015021-pol2qm74 4438 22 to to IN cord-015021-pol2qm74 4438 23 0,04 0,04 CD cord-015021-pol2qm74 4438 24 EH EH NNP cord-015021-pol2qm74 4438 25 / / , cord-015021-pol2qm74 4438 26 ml ml NN cord-015021-pol2qm74 4438 27 at at IN cord-015021-pol2qm74 4438 28 day day NN cord-015021-pol2qm74 4438 29 S S NNP cord-015021-pol2qm74 4438 30 and and CC cord-015021-pol2qm74 4438 31 remained remain VBD cord-015021-pol2qm74 4438 32 on on IN cord-015021-pol2qm74 4438 33 this this DT cord-015021-pol2qm74 4438 34 level level NN cord-015021-pol2qm74 4438 35 . . . cord-015021-pol2qm74 4439 1 SAC SAC NNP cord-015021-pol2qm74 4439 2 oflgMclass oflgMclass NNP cord-015021-pol2qm74 4439 3 increased increase VBD cord-015021-pol2qm74 4439 4 to to IN cord-015021-pol2qm74 4439 5 all all DT cord-015021-pol2qm74 4439 6 endotoxins endotoxin NNS cord-015021-pol2qm74 4439 7 and and CC cord-015021-pol2qm74 4439 8 peaked peak VBD cord-015021-pol2qm74 4439 9 at at IN cord-015021-pol2qm74 4439 10 day day NN cord-015021-pol2qm74 4439 11 3 3 CD cord-015021-pol2qm74 4439 12 revealing reveal VBG cord-015021-pol2qm74 4439 13 the the DT cord-015021-pol2qm74 4439 14 lfighest lfigh JJS cord-015021-pol2qm74 4439 15 level level NN cord-015021-pol2qm74 4439 16 to to IN cord-015021-pol2qm74 4439 17 LA LA NNP cord-015021-pol2qm74 4439 18 followed follow VBN cord-015021-pol2qm74 4439 19 by by IN cord-015021-pol2qm74 4439 20 PA PA NNP cord-015021-pol2qm74 4439 21 (= (= NNP cord-015021-pol2qm74 4439 22 80 80 CD cord-015021-pol2qm74 4439 23 % % NN cord-015021-pol2qm74 4439 24 of of IN cord-015021-pol2qm74 4439 25 LA LA NNP cord-015021-pol2qm74 4439 26 - - HYPH cord-015021-pol2qm74 4439 27 SAC SAC NNP cord-015021-pol2qm74 4439 28 ) ) -RRB- cord-015021-pol2qm74 4439 29 , , , cord-015021-pol2qm74 4439 30 EC EC NNP cord-015021-pol2qm74 4439 31 (= (= NNP cord-015021-pol2qm74 4439 32 65 65 CD cord-015021-pol2qm74 4439 33 % % NN cord-015021-pol2qm74 4439 34 of of IN cord-015021-pol2qm74 4439 35 LA LA NNP cord-015021-pol2qm74 4439 36 - - HYPH cord-015021-pol2qm74 4439 37 SAC SAC NNP cord-015021-pol2qm74 4439 38 ) ) -RRB- cord-015021-pol2qm74 4439 39 and and CC cord-015021-pol2qm74 4439 40 VC VC NNP cord-015021-pol2qm74 4439 41 (= (= NNP cord-015021-pol2qm74 4439 42 40 40 CD cord-015021-pol2qm74 4439 43 % % NN cord-015021-pol2qm74 4439 44 of of IN cord-015021-pol2qm74 4439 45 LA LA NNP cord-015021-pol2qm74 4439 46 - - HYPH cord-015021-pol2qm74 4439 47 SAC SAC NNP cord-015021-pol2qm74 4439 48 ) ) -RRB- cord-015021-pol2qm74 4439 49 . . . cord-015021-pol2qm74 4440 1 lgA lgA NNP cord-015021-pol2qm74 4440 2 antibodies antibody NNS cord-015021-pol2qm74 4440 3 increased increase VBD cord-015021-pol2qm74 4440 4 as as RB cord-015021-pol2qm74 4440 5 well well RB cord-015021-pol2qm74 4440 6 but but CC cord-015021-pol2qm74 4440 7 only only RB cord-015021-pol2qm74 4440 8 slightly slightly RB cord-015021-pol2qm74 4440 9 and and CC cord-015021-pol2qm74 4440 10 not not RB cord-015021-pol2qm74 4440 11 significant significant JJ cord-015021-pol2qm74 4440 12 ( ( -LRB- cord-015021-pol2qm74 4440 13 exception exception NN cord-015021-pol2qm74 4440 14 : : : cord-015021-pol2qm74 4440 15 SAC sac NN cord-015021-pol2qm74 4440 16 to to IN cord-015021-pol2qm74 4440 17 LA LA NNP cord-015021-pol2qm74 4440 18 was be VBD cord-015021-pol2qm74 4440 19 elevated elevate VBN cord-015021-pol2qm74 4440 20 significantly significantly RB cord-015021-pol2qm74 4440 21 at at IN cord-015021-pol2qm74 4440 22 day day NN cord-015021-pol2qm74 4440 23 5 5 CD cord-015021-pol2qm74 4440 24 ) ) -RRB- cord-015021-pol2qm74 4440 25 . . . cord-015021-pol2qm74 4441 1 IgG IgG NNP cord-015021-pol2qm74 4441 2 antibodies antibody NNS cord-015021-pol2qm74 4441 3 increased increase VBD cord-015021-pol2qm74 4441 4 similar similar JJ cord-015021-pol2qm74 4441 5 to to IN cord-015021-pol2qm74 4441 6 IgA IgA NNP cord-015021-pol2qm74 4441 7 class class NNP cord-015021-pol2qm74 4441 8 only only RB cord-015021-pol2qm74 4441 9 slightly slightly RB cord-015021-pol2qm74 4441 10 and and CC cord-015021-pol2qm74 4441 11 again again RB cord-015021-pol2qm74 4441 12 only only RB cord-015021-pol2qm74 4441 13 SAC sac NN cord-015021-pol2qm74 4441 14 to to IN cord-015021-pol2qm74 4441 15 LA LA NNP cord-015021-pol2qm74 4441 16 was be VBD cord-015021-pol2qm74 4441 17 significantly significantly RB cord-015021-pol2qm74 4441 18 higher high JJR cord-015021-pol2qm74 4441 19 at at IN cord-015021-pol2qm74 4441 20 day day NN cord-015021-pol2qm74 4441 21 5 5 CD cord-015021-pol2qm74 4441 22 and and CC cord-015021-pol2qm74 4441 23 10 10 CD cord-015021-pol2qm74 4441 24 . . . cord-015021-pol2qm74 4442 1 However however RB cord-015021-pol2qm74 4442 2 SAC sac NN cord-015021-pol2qm74 4442 3 to to IN cord-015021-pol2qm74 4442 4 ( ( -LRB- cord-015021-pol2qm74 4442 5 XH xh NN cord-015021-pol2qm74 4442 6 of of IN cord-015021-pol2qm74 4442 7 all all DT cord-015021-pol2qm74 4442 8 Ig Ig NNP cord-015021-pol2qm74 4442 9 - - HYPH cord-015021-pol2qm74 4442 10 classes class NNS cord-015021-pol2qm74 4442 11 remained remain VBD cord-015021-pol2qm74 4442 12 continuously continuously RB cord-015021-pol2qm74 4442 13 on on IN cord-015021-pol2qm74 4442 14 the the DT cord-015021-pol2qm74 4442 15 same same JJ cord-015021-pol2qm74 4442 16 level level NN cord-015021-pol2qm74 4442 17 troughout troughout VB cord-015021-pol2qm74 4442 18 the the DT cord-015021-pol2qm74 4442 19 observation observation NN cord-015021-pol2qm74 4442 20 time time NN cord-015021-pol2qm74 4442 21 . . . cord-015021-pol2qm74 4443 1 Correlation correlation NN cord-015021-pol2qm74 4443 2 analysis analysis NN cord-015021-pol2qm74 4443 3 revealed reveal VBD cord-015021-pol2qm74 4443 4 strong strong JJ cord-015021-pol2qm74 4443 5 cross cross NN cord-015021-pol2qm74 4443 6 - - NN cord-015021-pol2qm74 4443 7 reactivity reactivity JJ cord-015021-pol2qm74 4443 8 ( ( -LRB- cord-015021-pol2qm74 4443 9 r>0,5 r>0,5 UH cord-015021-pol2qm74 4443 10 ; ; : cord-015021-pol2qm74 4443 11 p<0,01 p<0,01 NN cord-015021-pol2qm74 4443 12 ) ) -RRB- cord-015021-pol2qm74 4443 13 most most RBS cord-015021-pol2qm74 4443 14 often often RB cord-015021-pol2qm74 4443 15 between between IN cord-015021-pol2qm74 4443 16 antibodies antibody NNS cord-015021-pol2qm74 4443 17 of of IN cord-015021-pol2qm74 4443 18 IgM IgM NNP cord-015021-pol2qm74 4443 19 - - HYPH cord-015021-pol2qm74 4443 20 elass elass NNP cord-015021-pol2qm74 4443 21 ( ( -LRB- cord-015021-pol2qm74 4443 22 73 73 CD cord-015021-pol2qm74 4443 23 % % NN cord-015021-pol2qm74 4443 24 ) ) -RRB- cord-015021-pol2qm74 4443 25 followed follow VBN cord-015021-pol2qm74 4443 26 by by IN cord-015021-pol2qm74 4443 27 IgAclass IgAclass NNP cord-015021-pol2qm74 4443 28 ( ( -LRB- cord-015021-pol2qm74 4443 29 40 40 CD cord-015021-pol2qm74 4443 30 % % NN cord-015021-pol2qm74 4443 31 ) ) -RRB- cord-015021-pol2qm74 4443 32 and and CC cord-015021-pol2qm74 4443 33 lgG lgG NNP cord-015021-pol2qm74 4443 34 class class NN cord-015021-pol2qm74 4443 35 ( ( -LRB- cord-015021-pol2qm74 4443 36 2 2 CD cord-015021-pol2qm74 4443 37 % % NN cord-015021-pol2qm74 4443 38 ] ] -RRB- cord-015021-pol2qm74 4443 39 . . . cord-015021-pol2qm74 4444 1 Conclusions conclusion NNS cord-015021-pol2qm74 4444 2 : : : cord-015021-pol2qm74 4445 1 Multiple multiple JJ cord-015021-pol2qm74 4445 2 trauma trauma NN cord-015021-pol2qm74 4445 3 is be VBZ cord-015021-pol2qm74 4445 4 associated associate VBN cord-015021-pol2qm74 4445 5 with with IN cord-015021-pol2qm74 4445 6 temporary temporary JJ cord-015021-pol2qm74 4445 7 endotoxemia endotoxemia NN cord-015021-pol2qm74 4445 8 . . . cord-015021-pol2qm74 4446 1 Endotoxins endotoxin NNS cord-015021-pol2qm74 4446 2 probably probably RB cord-015021-pol2qm74 4446 3 translocated translocate VBD cord-015021-pol2qm74 4446 4 from from IN cord-015021-pol2qm74 4446 5 the the DT cord-015021-pol2qm74 4446 6 gut gut NN cord-015021-pol2qm74 4446 7 cause cause VB cord-015021-pol2qm74 4446 8 specific specific JJ cord-015021-pol2qm74 4446 9 increase increase NN cord-015021-pol2qm74 4446 10 of of IN cord-015021-pol2qm74 4446 11 anti anti JJ cord-015021-pol2qm74 4446 12 endotoxin endotoxin NN cord-015021-pol2qm74 4446 13 antibodies antibody NNS cord-015021-pol2qm74 4446 14 in in IN cord-015021-pol2qm74 4446 15 blood blood NN cord-015021-pol2qm74 4446 16 of of IN cord-015021-pol2qm74 4446 17 the the DT cord-015021-pol2qm74 4446 18 IgM igm NN cord-015021-pol2qm74 4446 19 - - HYPH cord-015021-pol2qm74 4446 20 class class NNP cord-015021-pol2qm74 4446 21 . . . cord-015021-pol2qm74 4447 1 Endotoxins endotoxin NNS cord-015021-pol2qm74 4447 2 cause cause VBP cord-015021-pol2qm74 4447 3 no no DT cord-015021-pol2qm74 4447 4 increase increase NN cord-015021-pol2qm74 4447 5 of of IN cord-015021-pol2qm74 4447 6 antibodies antibody NNS cord-015021-pol2qm74 4447 7 to to IN cord-015021-pol2qm74 4447 8 gramposilave gramposilave NN cord-015021-pol2qm74 4447 9 bacteria bacteria NNS cord-015021-pol2qm74 4447 10 . . . cord-015021-pol2qm74 4448 1 IgM IgM NNP cord-015021-pol2qm74 4448 2 antibodies antibody NNS cord-015021-pol2qm74 4448 3 are be VBP cord-015021-pol2qm74 4448 4 most most RBS cord-015021-pol2qm74 4448 5 unspecific unspecific JJ cord-015021-pol2qm74 4448 6 . . . cord-015021-pol2qm74 4449 1 During during IN cord-015021-pol2qm74 4449 2 cardio cardio JJ cord-015021-pol2qm74 4449 3 - - HYPH cord-015021-pol2qm74 4449 4 pulmonary pulmonary JJ cord-015021-pol2qm74 4449 5 bypass bypass NN cord-015021-pol2qm74 4449 6 , , , cord-015021-pol2qm74 4449 7 as as RB cord-015021-pol2qm74 4449 8 well well RB cord-015021-pol2qm74 4449 9 as as IN cord-015021-pol2qm74 4449 10 postoperatively postoperatively RB cord-015021-pol2qm74 4449 11 , , , cord-015021-pol2qm74 4449 12 high high JJ cord-015021-pol2qm74 4449 13 levels level NNS cord-015021-pol2qm74 4449 14 of of IN cord-015021-pol2qm74 4449 15 endotoxin endotoxin NN cord-015021-pol2qm74 4449 16 , , , cord-015021-pol2qm74 4449 17 interleukin-6 interleukin-6 NNP cord-015021-pol2qm74 4449 18 ( ( -LRB- cord-015021-pol2qm74 4449 19 II-6 II-6 NNP cord-015021-pol2qm74 4449 20 ) ) -RRB- cord-015021-pol2qm74 4449 21 and and CC cord-015021-pol2qm74 4449 22 C C NNP cord-015021-pol2qm74 4449 23 - - HYPH cord-015021-pol2qm74 4449 24 reactive reactive JJ cord-015021-pol2qm74 4449 25 protein protein NN cord-015021-pol2qm74 4449 26 ( ( -LRB- cord-015021-pol2qm74 4449 27 CRP CRP NNP cord-015021-pol2qm74 4449 28 ) ) -RRB- cord-015021-pol2qm74 4449 29 were be VBD cord-015021-pol2qm74 4449 30 measured measure VBN cord-015021-pol2qm74 4449 31 in in IN cord-015021-pol2qm74 4449 32 30 30 CD cord-015021-pol2qm74 4449 33 patients patient NNS cord-015021-pol2qm74 4449 34 . . . cord-015021-pol2qm74 4450 1 I0 i0 NN cord-015021-pol2qm74 4450 2 female female JJ cord-015021-pol2qm74 4450 3 and and CC cord-015021-pol2qm74 4450 4 20 20 CD cord-015021-pol2qm74 4450 5 male male JJ cord-015021-pol2qm74 4450 6 , , , cord-015021-pol2qm74 4450 7 ageing age VBG cord-015021-pol2qm74 4450 8 from from IN cord-015021-pol2qm74 4450 9 30 30 CD cord-015021-pol2qm74 4450 10 to to IN cord-015021-pol2qm74 4450 11 73 73 CD cord-015021-pol2qm74 4450 12 with with IN cord-015021-pol2qm74 4450 13 a a DT cord-015021-pol2qm74 4450 14 median median JJ cord-015021-pol2qm74 4450 15 age age NN cord-015021-pol2qm74 4450 16 of of IN cord-015021-pol2qm74 4450 17 59 59 CD cord-015021-pol2qm74 4450 18 . . . cord-015021-pol2qm74 4451 1 Blood blood NN cord-015021-pol2qm74 4451 2 sampling sampling NN cord-015021-pol2qm74 4451 3 was be VBD cord-015021-pol2qm74 4451 4 done do VBN cord-015021-pol2qm74 4451 5 preoperatively preoperatively RB cord-015021-pol2qm74 4451 6 , , , cord-015021-pol2qm74 4451 7 immediately immediately RB cord-015021-pol2qm74 4451 8 after after IN cord-015021-pol2qm74 4451 9 induction induction NN cord-015021-pol2qm74 4451 10 of of IN cord-015021-pol2qm74 4451 11 anaesthesia anaesthesia NN cord-015021-pol2qm74 4451 12 , , , cord-015021-pol2qm74 4451 13 after after IN cord-015021-pol2qm74 4451 14 thoracotomy thoracotomy NN cord-015021-pol2qm74 4451 15 , , , cord-015021-pol2qm74 4451 16 after after IN cord-015021-pol2qm74 4451 17 cannulation cannulation NN cord-015021-pol2qm74 4451 18 of of IN cord-015021-pol2qm74 4451 19 the the DT cord-015021-pol2qm74 4451 20 aorta aorta NNP cord-015021-pol2qm74 4451 21 and and CC cord-015021-pol2qm74 4451 22 right right JJ cord-015021-pol2qm74 4451 23 atrium atrium NN cord-015021-pol2qm74 4451 24 after after IN cord-015021-pol2qm74 4451 25 the the DT cord-015021-pol2qm74 4451 26 first first JJ cord-015021-pol2qm74 4451 27 half half NN cord-015021-pol2qm74 4451 28 of of IN cord-015021-pol2qm74 4451 29 the the DT cord-015021-pol2qm74 4451 30 reperfusion reperfusion NN cord-015021-pol2qm74 4451 31 phase phase NN cord-015021-pol2qm74 4451 32 , , , cord-015021-pol2qm74 4451 33 after after IN cord-015021-pol2qm74 4451 34 closure closure NN cord-015021-pol2qm74 4451 35 of of IN cord-015021-pol2qm74 4451 36 the the DT cord-015021-pol2qm74 4451 37 thorax thorax NN cord-015021-pol2qm74 4451 38 , , , cord-015021-pol2qm74 4451 39 2 2 CD cord-015021-pol2qm74 4451 40 and and CC cord-015021-pol2qm74 4451 41 4 4 CD cord-015021-pol2qm74 4451 42 hours hour NNS cord-015021-pol2qm74 4451 43 after after IN cord-015021-pol2qm74 4451 44 the the DT cord-015021-pol2qm74 4451 45 operation operation NN cord-015021-pol2qm74 4452 1 and and CC cord-015021-pol2qm74 4452 2 then then RB cord-015021-pol2qm74 4452 3 every every DT cord-015021-pol2qm74 4452 4 morning morning NN cord-015021-pol2qm74 4452 5 until until IN cord-015021-pol2qm74 4452 6 the the DT cord-015021-pol2qm74 4452 7 5th 5th JJ cord-015021-pol2qm74 4452 8 postoperative postoperative JJ cord-015021-pol2qm74 4452 9 day day NN cord-015021-pol2qm74 4452 10 . . . cord-015021-pol2qm74 4453 1 Blood blood NN cord-015021-pol2qm74 4453 2 was be VBD cord-015021-pol2qm74 4453 3 drawn draw VBN cord-015021-pol2qm74 4453 4 into into IN cord-015021-pol2qm74 4453 5 heparinized heparinize VBN cord-015021-pol2qm74 4453 6 tubes tube NNS cord-015021-pol2qm74 4453 7 ( ( -LRB- cord-015021-pol2qm74 4453 8 I0 I0 NNP cord-015021-pol2qm74 4453 9 IU IU NNP cord-015021-pol2qm74 4453 10 / / SYM cord-015021-pol2qm74 4453 11 ml ml NN cord-015021-pol2qm74 4453 12 ) ) -RRB- cord-015021-pol2qm74 4453 13 which which WDT cord-015021-pol2qm74 4453 14 were be VBD cord-015021-pol2qm74 4453 15 free free JJ cord-015021-pol2qm74 4453 16 of of IN cord-015021-pol2qm74 4453 17 endotoxin endotoxin NN cord-015021-pol2qm74 4453 18 . . . cord-015021-pol2qm74 4454 1 CRP CRP NNP cord-015021-pol2qm74 4454 2 levels level NNS cord-015021-pol2qm74 4454 3 were be VBD cord-015021-pol2qm74 4454 4 determined determine VBN cord-015021-pol2qm74 4454 5 through through IN cord-015021-pol2qm74 4454 6 the the DT cord-015021-pol2qm74 4454 7 use use NN cord-015021-pol2qm74 4454 8 of of IN cord-015021-pol2qm74 4454 9 the the DT cord-015021-pol2qm74 4454 10 Behring Behring NNP cord-015021-pol2qm74 4454 11 Nephelometer Nephelometer NNP cord-015021-pol2qm74 4454 12 . . . cord-015021-pol2qm74 4455 1 11 11 CD cord-015021-pol2qm74 4455 2 - - SYM cord-015021-pol2qm74 4455 3 6 6 CD cord-015021-pol2qm74 4455 4 levels level NNS cord-015021-pol2qm74 4455 5 were be VBD cord-015021-pol2qm74 4455 6 measured measure VBN cord-015021-pol2qm74 4455 7 by by IN cord-015021-pol2qm74 4455 8 using use VBG cord-015021-pol2qm74 4455 9 commercially commercially RB cord-015021-pol2qm74 4455 10 - - HYPH cord-015021-pol2qm74 4455 11 available available JJ cord-015021-pol2qm74 4455 12 ELISA ELISA NNP cord-015021-pol2qm74 4455 13 test test NN cord-015021-pol2qm74 4455 14 . . . cord-015021-pol2qm74 4456 1 The the DT cord-015021-pol2qm74 4456 2 endotoxin endotoxin NN cord-015021-pol2qm74 4456 3 level level NN cord-015021-pol2qm74 4456 4 was be VBD cord-015021-pol2qm74 4456 5 determined determine VBN cord-015021-pol2qm74 4456 6 by by IN cord-015021-pol2qm74 4456 7 a a DT cord-015021-pol2qm74 4456 8 chromogenic chromogenic JJ cord-015021-pol2qm74 4456 9 modification modification NN cord-015021-pol2qm74 4456 10 of of IN cord-015021-pol2qm74 4456 11 the the DT cord-015021-pol2qm74 4456 12 limulus limulus NNP cord-015021-pol2qm74 4456 13 amebocyte amebocyte NNP cord-015021-pol2qm74 4456 14 test test NN cord-015021-pol2qm74 4456 15 . . . cord-015021-pol2qm74 4457 1 The the DT cord-015021-pol2qm74 4457 2 statistical statistical JJ cord-015021-pol2qm74 4457 3 analysis analysis NN cord-015021-pol2qm74 4457 4 was be VBD cord-015021-pol2qm74 4457 5 done do VBN cord-015021-pol2qm74 4457 6 using use VBG cord-015021-pol2qm74 4457 7 the the DT cord-015021-pol2qm74 4457 8 Wilcoxon Wilcoxon NNP cord-015021-pol2qm74 4457 9 ranks rank VBZ cord-015021-pol2qm74 4457 10 test test NN cord-015021-pol2qm74 4457 11 and and CC cord-015021-pol2qm74 4457 12 correlation correlation NN cord-015021-pol2qm74 4457 13 analysis analysis NN cord-015021-pol2qm74 4457 14 . . . cord-015021-pol2qm74 4458 1 A a DT cord-015021-pol2qm74 4458 2 significant significant JJ cord-015021-pol2qm74 4458 3 increase increase NN cord-015021-pol2qm74 4458 4 { { -LRB- cord-015021-pol2qm74 4458 5 p p NN cord-015021-pol2qm74 4458 6 0.01 0.01 CD cord-015021-pol2qm74 4458 7 ) ) -RRB- cord-015021-pol2qm74 4458 8 in in IN cord-015021-pol2qm74 4458 9 endotoxin endotoxin NN cord-015021-pol2qm74 4458 10 plasma plasma NN cord-015021-pol2qm74 4458 11 occurred occur VBD cord-015021-pol2qm74 4458 12 during during IN cord-015021-pol2qm74 4458 13 surgery surgery NN cord-015021-pol2qm74 4458 14 , , , cord-015021-pol2qm74 4458 15 culminating culminate VBG cord-015021-pol2qm74 4458 16 in in IN cord-015021-pol2qm74 4458 17 a a DT cord-015021-pol2qm74 4458 18 peak peak NN cord-015021-pol2qm74 4458 19 ( ( -LRB- cord-015021-pol2qm74 4458 20 median median JJ cord-015021-pol2qm74 4458 21 value value NN cord-015021-pol2qm74 4458 22 of of IN cord-015021-pol2qm74 4458 23 0.795 0.795 CD cord-015021-pol2qm74 4458 24 EU EU NNP cord-015021-pol2qm74 4458 25 / / SYM cord-015021-pol2qm74 4458 26 m m NN cord-015021-pol2qm74 4458 27 ! ! . cord-015021-pol2qm74 4458 28 ) ) -RRB- cord-015021-pol2qm74 4459 1 during during IN cord-015021-pol2qm74 4459 2 reperfusicn reperfusicn NNP cord-015021-pol2qm74 4459 3 . . . cord-015021-pol2qm74 4460 1 Plasma plasma NN cord-015021-pol2qm74 4460 2 levels level NNS cord-015021-pol2qm74 4460 3 of of IN cord-015021-pol2qm74 4460 4 endotoxin endotoxin NN cord-015021-pol2qm74 4460 5 continued continue VBD cord-015021-pol2qm74 4460 6 to to TO cord-015021-pol2qm74 4460 7 be be VB cord-015021-pol2qm74 4460 8 slightly slightly RB cord-015021-pol2qm74 4460 9 raised raise VBN cord-015021-pol2qm74 4460 10 till till IN cord-015021-pol2qm74 4460 11 the the DT cord-015021-pol2qm74 4460 12 5th 5th JJ cord-015021-pol2qm74 4460 13 day day NN cord-015021-pol2qm74 4460 14 after after IN cord-015021-pol2qm74 4460 15 surgery surgery NN cord-015021-pol2qm74 4460 16 , , , cord-015021-pol2qm74 4460 17 whereas whereas IN cord-015021-pol2qm74 4460 18 those those DT cord-015021-pol2qm74 4460 19 of of IN cord-015021-pol2qm74 4460 20 interleukin-6 interleukin-6 NNP cord-015021-pol2qm74 4460 21 rose rise VBD cord-015021-pol2qm74 4460 22 at at IN cord-015021-pol2qm74 4460 23 the the DT cord-015021-pol2qm74 4460 24 end end NN cord-015021-pol2qm74 4460 25 of of IN cord-015021-pol2qm74 4460 26 the the DT cord-015021-pol2qm74 4460 27 operation operation NN cord-015021-pol2qm74 4460 28 and and CC cord-015021-pol2qm74 4460 29 were be VBD cord-015021-pol2qm74 4460 30 at at IN cord-015021-pol2qm74 4460 31 their -PRON- PRP$ cord-015021-pol2qm74 4460 32 highest high JJS cord-015021-pol2qm74 4460 33 4 4 CD cord-015021-pol2qm74 4460 34 hours hour NNS cord-015021-pol2qm74 4460 35 later later RB cord-015021-pol2qm74 4460 36 ( ( -LRB- cord-015021-pol2qm74 4460 37 median median JJ cord-015021-pol2qm74 4460 38 value value NN cord-015021-pol2qm74 4460 39 of of IN cord-015021-pol2qm74 4460 40 217.5 217.5 CD cord-015021-pol2qm74 4460 41 pg pg NNP cord-015021-pol2qm74 4460 42 / / SYM cord-015021-pol2qm74 4460 43 ml ml NNP cord-015021-pol2qm74 4460 44 ) ) -RRB- cord-015021-pol2qm74 4460 45 . . . cord-015021-pol2qm74 4461 1 CRP CRP NNP cord-015021-pol2qm74 4461 2 levels level NNS cord-015021-pol2qm74 4461 3 were be VBD cord-015021-pol2qm74 4461 4 also also RB cord-015021-pol2qm74 4461 5 high high JJ cord-015021-pol2qm74 4461 6 postoperatively postoperatively RB cord-015021-pol2qm74 4461 7 with with IN cord-015021-pol2qm74 4461 8 a a DT cord-015021-pol2qm74 4461 9 median median JJ cord-015021-pol2qm74 4461 10 value value NN cord-015021-pol2qm74 4461 11 of of IN cord-015021-pol2qm74 4461 12 114 114 CD cord-015021-pol2qm74 4461 13 mg mg NNP cord-015021-pol2qm74 4461 14 / / SYM cord-015021-pol2qm74 4461 15 l l NNP cord-015021-pol2qm74 4461 16 , , , cord-015021-pol2qm74 4461 17 and and CC cord-015021-pol2qm74 4461 18 were be VBD cord-015021-pol2qm74 4461 19 markedly markedly RB cord-015021-pol2qm74 4461 20 raised raise VBN cord-015021-pol2qm74 4461 21 on on IN cord-015021-pol2qm74 4461 22 day day NN cord-015021-pol2qm74 4461 23 2 2 CD cord-015021-pol2qm74 4461 24 ( ( -LRB- cord-015021-pol2qm74 4461 25 191 191 CD cord-015021-pol2qm74 4461 26 mg mg NNP cord-015021-pol2qm74 4461 27 / / SYM cord-015021-pol2qm74 4461 28 l l NN cord-015021-pol2qm74 4461 29 ) ) -RRB- cord-015021-pol2qm74 4461 30 . . . cord-015021-pol2qm74 4462 1 A a DT cord-015021-pol2qm74 4462 2 definite definite JJ cord-015021-pol2qm74 4462 3 , , , cord-015021-pol2qm74 4462 4 statistically statistically RB cord-015021-pol2qm74 4462 5 significant significant JJ cord-015021-pol2qm74 4462 6 correlation correlation NN cord-015021-pol2qm74 4462 7 between between IN cord-015021-pol2qm74 4462 8 the the DT cord-015021-pol2qm74 4462 9 plasma plasma NN cord-015021-pol2qm74 4462 10 levels level NNS cord-015021-pol2qm74 4462 11 of of IN cord-015021-pol2qm74 4462 12 endotoxin endotoxin NN cord-015021-pol2qm74 4462 13 and and CC cord-015021-pol2qm74 4462 14 11 11 CD cord-015021-pol2qm74 4462 15 - - SYM cord-015021-pol2qm74 4462 16 6 6 CD cord-015021-pol2qm74 4462 17 during during IN cord-015021-pol2qm74 4462 18 the the DT cord-015021-pol2qm74 4462 19 operation operation NN cord-015021-pol2qm74 4462 20 was be VBD cord-015021-pol2qm74 4462 21 establisthed establisthe VBN cord-015021-pol2qm74 4462 22 ( ( -LRB- cord-015021-pol2qm74 4462 23 p p NN cord-015021-pol2qm74 4462 24 0.05 0.05 CD cord-015021-pol2qm74 4462 25 ) ) -RRB- cord-015021-pol2qm74 4462 26 , , , cord-015021-pol2qm74 4462 27 leading lead VBG cord-015021-pol2qm74 4462 28 us -PRON- PRP cord-015021-pol2qm74 4462 29 to to TO cord-015021-pol2qm74 4462 30 conclude conclude VB cord-015021-pol2qm74 4462 31 that that IN cord-015021-pol2qm74 4462 32 the the DT cord-015021-pol2qm74 4462 33 endotoxin endotoxin NN cord-015021-pol2qm74 4462 34 liberated liberate VBN cord-015021-pol2qm74 4462 35 during during IN cord-015021-pol2qm74 4462 36 cardiac cardiac JJ cord-015021-pol2qm74 4462 37 surgery surgery NN cord-015021-pol2qm74 4462 38 acts act NNS cord-015021-pol2qm74 4462 39 as as IN cord-015021-pol2qm74 4462 40 the the DT cord-015021-pol2qm74 4462 41 main main JJ cord-015021-pol2qm74 4462 42 trigger trigger NN cord-015021-pol2qm74 4462 43 in in IN cord-015021-pol2qm74 4462 44 the the DT cord-015021-pol2qm74 4462 45 releasing releasing NN cord-015021-pol2qm74 4462 46 of of IN cord-015021-pol2qm74 4462 47 11 11 CD cord-015021-pol2qm74 4462 48 - - SYM cord-015021-pol2qm74 4462 49 6 6 CD cord-015021-pol2qm74 4462 50 , , , cord-015021-pol2qm74 4462 51 and and CC cord-015021-pol2qm74 4462 52 thus thus RB cord-015021-pol2qm74 4462 53 induces induce VBZ cord-015021-pol2qm74 4462 54 the the DT cord-015021-pol2qm74 4462 55 postoperative postoperative JJ cord-015021-pol2qm74 4462 56 acute acute JJ cord-015021-pol2qm74 4462 57 phase phase NN cord-015021-pol2qm74 4462 58 reaction reaction NN cord-015021-pol2qm74 4462 59 . . . cord-015021-pol2qm74 4463 1 There there EX cord-015021-pol2qm74 4463 2 was be VBD cord-015021-pol2qm74 4463 3 no no DT cord-015021-pol2qm74 4463 4 evidence evidence NN cord-015021-pol2qm74 4463 5 of of IN cord-015021-pol2qm74 4463 6 a a DT cord-015021-pol2qm74 4463 7 correlation correlation NN cord-015021-pol2qm74 4463 8 between between IN cord-015021-pol2qm74 4463 9 CRP crp NN cord-015021-pol2qm74 4463 10 and and CC cord-015021-pol2qm74 4463 11 endotoxin endotoxin NN cord-015021-pol2qm74 4463 12 or or CC cord-015021-pol2qm74 4463 13 11 11 CD cord-015021-pol2qm74 4463 14 - - SYM cord-015021-pol2qm74 4463 15 6 6 CD cord-015021-pol2qm74 4463 16 plasma plasma NN cord-015021-pol2qm74 4463 17 levels level NNS cord-015021-pol2qm74 4463 18 . . . cord-015021-pol2qm74 4464 1 Impaired impaired JJ cord-015021-pol2qm74 4464 2 immune immune JJ cord-015021-pol2qm74 4464 3 function function NN cord-015021-pol2qm74 4464 4 is be VBZ cord-015021-pol2qm74 4464 5 well well RB cord-015021-pol2qm74 4464 6 described describe VBN cord-015021-pol2qm74 4464 7 following follow VBG cord-015021-pol2qm74 4464 8 trauma trauma NN cord-015021-pol2qm74 4464 9 and and CC cord-015021-pol2qm74 4464 10 hemorrhagic hemorrhagic JJ cord-015021-pol2qm74 4464 11 shock shock NN cord-015021-pol2qm74 4464 12 ( ( -LRB- cord-015021-pol2qm74 4464 13 HS HS NNP cord-015021-pol2qm74 4464 14 ) ) -RRB- cord-015021-pol2qm74 4464 15 . . . cord-015021-pol2qm74 4465 1 Prior prior JJ cord-015021-pol2qm74 4465 2 studies study NNS cord-015021-pol2qm74 4465 3 have have VBP cord-015021-pol2qm74 4465 4 utilized utilize VBN cord-015021-pol2qm74 4465 5 peripheral peripheral JJ cord-015021-pol2qm74 4465 6 blood blood NN cord-015021-pol2qm74 4465 7 or or CC cord-015021-pol2qm74 4465 8 spleen spleen NN cord-015021-pol2qm74 4465 9 cells cell NNS cord-015021-pol2qm74 4465 10 to to IN cord-015021-pol2qm74 4465 11 index index NN cord-015021-pol2qm74 4465 12 immune immune JJ cord-015021-pol2qm74 4465 13 function function NN cord-015021-pol2qm74 4465 14 following follow VBG cord-015021-pol2qm74 4465 15 HS HS NNP cord-015021-pol2qm74 4465 16 . . . cord-015021-pol2qm74 4466 1 However however RB cord-015021-pol2qm74 4466 2 , , , cord-015021-pol2qm74 4466 3 changes change NNS cord-015021-pol2qm74 4466 4 in in IN cord-015021-pol2qm74 4466 5 mucosal mucosal JJ cord-015021-pol2qm74 4466 6 immunity immunity NN cord-015021-pol2qm74 4466 7 are be VBP cord-015021-pol2qm74 4466 8 not not RB cord-015021-pol2qm74 4466 9 weII weII NNP cord-015021-pol2qm74 4466 10 characterized characterize VBN cord-015021-pol2qm74 4466 11 in in IN cord-015021-pol2qm74 4466 12 this this DT cord-015021-pol2qm74 4466 13 setting setting NN cord-015021-pol2qm74 4466 14 . . . cord-015021-pol2qm74 4467 1 Gut gut JJ cord-015021-pol2qm74 4467 2 origin origin NN cord-015021-pol2qm74 4467 3 sepsis sepsis NN cord-015021-pol2qm74 4467 4 is be VBZ cord-015021-pol2qm74 4467 5 thought think VBN cord-015021-pol2qm74 4467 6 to to TO cord-015021-pol2qm74 4467 7 be be VB cord-015021-pol2qm74 4467 8 an an DT cord-015021-pol2qm74 4467 9 important important JJ cord-015021-pol2qm74 4467 10 cause cause NN cord-015021-pol2qm74 4467 11 of of IN cord-015021-pol2qm74 4467 12 organ organ NN cord-015021-pol2qm74 4467 13 failure failure NN cord-015021-pol2qm74 4467 14 and and CC cord-015021-pol2qm74 4467 15 death death NN cord-015021-pol2qm74 4467 16 following follow VBG cord-015021-pol2qm74 4467 17 trauma trauma NN cord-015021-pol2qm74 4467 18 . . . cord-015021-pol2qm74 4468 1 A a DT cord-015021-pol2qm74 4468 2 rodent rodent NN cord-015021-pol2qm74 4468 3 model model NN cord-015021-pol2qm74 4468 4 was be VBD cord-015021-pol2qm74 4468 5 utilized utilize VBN cord-015021-pol2qm74 4468 6 to to TO cord-015021-pol2qm74 4468 7 allow allow VB cord-015021-pol2qm74 4468 8 comparison comparison NN cord-015021-pol2qm74 4468 9 of of IN cord-015021-pol2qm74 4468 10 mucosal mucosal JJ cord-015021-pol2qm74 4468 11 - - HYPH cord-015021-pol2qm74 4468 12 associated associated JJ cord-015021-pol2qm74 4468 13 immune immune JJ cord-015021-pol2qm74 4468 14 function function NN cord-015021-pol2qm74 4468 15 vs vs IN cord-015021-pol2qm74 4468 16 , , , cord-015021-pol2qm74 4468 17 systemic systemic JJ cord-015021-pol2qm74 4468 18 compartments compartment NNS cord-015021-pol2qm74 4468 19 after after IN cord-015021-pol2qm74 4468 20 HS HS NNP cord-015021-pol2qm74 4468 21 . . . cord-015021-pol2qm74 4469 1 Fischer Fischer NNP cord-015021-pol2qm74 4469 2 rates rate NNS cord-015021-pol2qm74 4469 3 underwent undergo VBD cord-015021-pol2qm74 4469 4 HS HS NNP cord-015021-pol2qm74 4469 5 ( ( -LRB- cord-015021-pol2qm74 4469 6 MAP MAP NNP cord-015021-pol2qm74 4469 7 35±5 35±5 CD cord-015021-pol2qm74 4469 8 mm mm CD cord-015021-pol2qm74 4469 9 Hg Hg NNP cord-015021-pol2qm74 4469 10 ) ) -RRB- cord-015021-pol2qm74 4469 11 for for IN cord-015021-pol2qm74 4469 12 60 60 CD cord-015021-pol2qm74 4469 13 minutes minute NNS cord-015021-pol2qm74 4469 14 followed follow VBN cord-015021-pol2qm74 4469 15 by by IN cord-015021-pol2qm74 4469 16 resuscitation resuscitation NN cord-015021-pol2qm74 4469 17 with with IN cord-015021-pol2qm74 4469 18 shed shed JJ cord-015021-pol2qm74 4469 19 blood blood NN cord-015021-pol2qm74 4469 20 and and CC cord-015021-pol2qm74 4469 21 LR LR NNP cord-015021-pol2qm74 4469 22 . . . cord-015021-pol2qm74 4470 1 Sham sham JJ cord-015021-pol2qm74 4470 2 animals animal NNS cord-015021-pol2qm74 4470 3 were be VBD cord-015021-pol2qm74 4470 4 instrumented instrument VBN cord-015021-pol2qm74 4470 5 only only RB cord-015021-pol2qm74 4470 6 . . . cord-015021-pol2qm74 4471 1 Rat rat NN cord-015021-pol2qm74 4471 2 tears tear NNS cord-015021-pol2qm74 4471 3 were be VBD cord-015021-pol2qm74 4471 4 collected collect VBN cord-015021-pol2qm74 4471 5 at at IN cord-015021-pol2qm74 4471 6 24 24 CD cord-015021-pol2qm74 4471 7 and and CC cord-015021-pol2qm74 4471 8 72 72 CD cord-015021-pol2qm74 4471 9 hours hour NNS cord-015021-pol2qm74 4471 10 following follow VBG cord-015021-pol2qm74 4471 11 HS HS NNP cord-015021-pol2qm74 4471 12 for for IN cord-015021-pol2qm74 4471 13 quantitation quantitation NN cord-015021-pol2qm74 4471 14 of of IN cord-015021-pol2qm74 4471 15 slgA slga NN cord-015021-pol2qm74 4471 16 by by IN cord-015021-pol2qm74 4471 17 RIA RIA NNP cord-015021-pol2qm74 4471 18 . . . cord-015021-pol2qm74 4472 1 Animals animal NNS cord-015021-pol2qm74 4472 2 were be VBD cord-015021-pol2qm74 4472 3 sacrificed sacrifice VBN cord-015021-pol2qm74 4472 4 at at IN cord-015021-pol2qm74 4472 5 24 24 CD cord-015021-pol2qm74 4472 6 hours hour NNS cord-015021-pol2qm74 4472 7 and and CC cord-015021-pol2qm74 4472 8 spleen spleen NNS cord-015021-pol2qm74 4472 9 ( ( -LRB- cord-015021-pol2qm74 4472 10 SPL SPL NNP cord-015021-pol2qm74 4472 11 ) ) -RRB- cord-015021-pol2qm74 4472 12 , , , cord-015021-pol2qm74 4472 13 peripheral peripheral JJ cord-015021-pol2qm74 4472 14 lymph lymph NN cord-015021-pol2qm74 4472 15 nodes node NNS cord-015021-pol2qm74 4472 16 ( ( -LRB- cord-015021-pol2qm74 4472 17 PLN PLN NNP cord-015021-pol2qm74 4472 18 ) ) -RRB- cord-015021-pol2qm74 4472 19 , , , cord-015021-pol2qm74 4472 20 and and CC cord-015021-pol2qm74 4472 21 mesenteric mesenteric JJ cord-015021-pol2qm74 4472 22 lymph lymph NN cord-015021-pol2qm74 4472 23 nodes node NNS cord-015021-pol2qm74 4472 24 ( ( -LRB- cord-015021-pol2qm74 4472 25 MLN mln NN cord-015021-pol2qm74 4472 26 ) ) -RRB- cord-015021-pol2qm74 4472 27 harvested harvest VBN cord-015021-pol2qm74 4472 28 for for IN cord-015021-pol2qm74 4472 29 cell cell NN cord-015021-pol2qm74 4472 30 population population NN cord-015021-pol2qm74 4472 31 analysis analysis NN cord-015021-pol2qm74 4472 32 using use VBG cord-015021-pol2qm74 4472 33 flow flow NN cord-015021-pol2qm74 4472 34 cytometry cytometry NN cord-015021-pol2qm74 4472 35 and and CC cord-015021-pol2qm74 4472 36 mitogen mitogen NN cord-015021-pol2qm74 4472 37 stimulation stimulation NN cord-015021-pol2qm74 4472 38 analysis analysis NN cord-015021-pol2qm74 4472 39 . . . cord-015021-pol2qm74 4473 1 Cell cell NN cord-015021-pol2qm74 4473 2 marker marker NN cord-015021-pol2qm74 4473 3 expression expression NN cord-015021-pol2qm74 4473 4 analysis analysis NN cord-015021-pol2qm74 4473 5 revealed reveal VBD cord-015021-pol2qm74 4473 6 no no DT cord-015021-pol2qm74 4473 7 changes change NNS cord-015021-pol2qm74 4473 8 in in IN cord-015021-pol2qm74 4473 9 T T NNP cord-015021-pol2qm74 4473 10 or or CC cord-015021-pol2qm74 4473 11 B B NNP cord-015021-pol2qm74 4473 12 ceil ceil NN cord-015021-pol2qm74 4473 13 populations population NNS cord-015021-pol2qm74 4473 14 following follow VBG cord-015021-pol2qm74 4473 15 HS HS NNP cord-015021-pol2qm74 4473 16 . . . cord-015021-pol2qm74 4474 1 Mitogen Mitogen NNP cord-015021-pol2qm74 4474 2 Mucosal Mucosal NNP cord-015021-pol2qm74 4474 3 immune immune JJ cord-015021-pol2qm74 4474 4 function function NN cord-015021-pol2qm74 4474 5 appears appear VBZ cord-015021-pol2qm74 4474 6 relatively relatively RB cord-015021-pol2qm74 4474 7 spared spared JJ cord-015021-pol2qm74 4474 8 following follow VBG cord-015021-pol2qm74 4474 9 HS HS NNP cord-015021-pol2qm74 4474 10 . . . cord-015021-pol2qm74 4475 1 The the DT cord-015021-pol2qm74 4475 2 mechanism(s mechanism(s NNP cord-015021-pol2qm74 4475 3 ) ) -RRB- cord-015021-pol2qm74 4475 4 for for IN cord-015021-pol2qm74 4475 5 this this DT cord-015021-pol2qm74 4475 6 variability variability NN cord-015021-pol2qm74 4475 7 in in IN cord-015021-pol2qm74 4475 8 immune immune JJ cord-015021-pol2qm74 4475 9 function function NN cord-015021-pol2qm74 4475 10 requires require VBZ cord-015021-pol2qm74 4475 11 further further JJ cord-015021-pol2qm74 4475 12 investigation investigation NN cord-015021-pol2qm74 4475 13 . . . cord-015021-pol2qm74 4476 1 We -PRON- PRP cord-015021-pol2qm74 4476 2 have have VBP cord-015021-pol2qm74 4476 3 found find VBN cord-015021-pol2qm74 4476 4 that that IN cord-015021-pol2qm74 4476 5 transplantation transplantation NN cord-015021-pol2qm74 4476 6 of of IN cord-015021-pol2qm74 4476 7 bone bone NN cord-015021-pol2qm74 4476 8 marrow marrow NN cord-015021-pol2qm74 4476 9 in in IN cord-015021-pol2qm74 4476 10 a a DT cord-015021-pol2qm74 4476 11 hind hind JJ cord-015021-pol2qm74 4476 12 - - HYPH cord-015021-pol2qm74 4476 13 limb limb NN cord-015021-pol2qm74 4476 14 graft graft NN cord-015021-pol2qm74 4476 15 to to IN cord-015021-pol2qm74 4476 16 syngeneic syngeneic NNS cord-015021-pol2qm74 4476 17 lethally lethally RB cord-015021-pol2qm74 4476 18 irradiated irradiate VBD cord-015021-pol2qm74 4476 19 recipient recipient NN cord-015021-pol2qm74 4476 20 is be VBZ cord-015021-pol2qm74 4476 21 followed follow VBN cord-015021-pol2qm74 4476 22 not not RB cord-015021-pol2qm74 4476 23 only only RB cord-015021-pol2qm74 4476 24 by by IN cord-015021-pol2qm74 4476 25 rapid rapid JJ cord-015021-pol2qm74 4476 26 repopulafion repopulafion NN cord-015021-pol2qm74 4476 27 but but CC cord-015021-pol2qm74 4476 28 also also RB cord-015021-pol2qm74 4476 29 overpopulation overpopulation NN cord-015021-pol2qm74 4476 30 of of IN cord-015021-pol2qm74 4476 31 bone bone NN cord-015021-pol2qm74 4476 32 marrow marrow NN cord-015021-pol2qm74 4476 33 cavities cavity NNS cord-015021-pol2qm74 4476 34 . . . cord-015021-pol2qm74 4477 1 The the DT cord-015021-pol2qm74 4477 2 question question NN cord-015021-pol2qm74 4477 3 arises arise VBZ cord-015021-pol2qm74 4477 4 whether whether IN cord-015021-pol2qm74 4477 5 this this DT cord-015021-pol2qm74 4477 6 unexpected unexpected JJ cord-015021-pol2qm74 4477 7 phenomenon phenomenon NN cord-015021-pol2qm74 4477 8 could could MD cord-015021-pol2qm74 4477 9 be be VB cord-015021-pol2qm74 4477 10 the the DT cord-015021-pol2qm74 4477 11 result result NN cord-015021-pol2qm74 4477 12 of of IN cord-015021-pol2qm74 4477 13 stimulation stimulation NN cord-015021-pol2qm74 4477 14 of of IN cord-015021-pol2qm74 4477 15 stem stem NN cord-015021-pol2qm74 4477 16 cells cell NNS cord-015021-pol2qm74 4477 17 by by IN cord-015021-pol2qm74 4477 18 factors factor NNS cord-015021-pol2qm74 4477 19 ( ( -LRB- cord-015021-pol2qm74 4477 20 cytokines cytokine NNS cord-015021-pol2qm74 4477 21 ) ) -RRB- cord-015021-pol2qm74 4477 22 released release VBN cord-015021-pol2qm74 4477 23 from from IN cord-015021-pol2qm74 4477 24 surgical surgical JJ cord-015021-pol2qm74 4477 25 wound wound NN cord-015021-pol2qm74 4477 26 at at IN cord-015021-pol2qm74 4477 27 the the DT cord-015021-pol2qm74 4477 28 site site NN cord-015021-pol2qm74 4477 29 of of IN cord-015021-pol2qm74 4477 30 anastomosis anastomosis NN cord-015021-pol2qm74 4477 31 of of IN cord-015021-pol2qm74 4477 32 graft graft NN cord-015021-pol2qm74 4477 33 with with IN cord-015021-pol2qm74 4477 34 recipient recipient NN cord-015021-pol2qm74 4477 35 . . . cord-015021-pol2qm74 4478 1 AIM aim VB cord-015021-pol2qm74 4478 2 OF of IN cord-015021-pol2qm74 4478 3 THE the DT cord-015021-pol2qm74 4478 4 STUDY study NN cord-015021-pol2qm74 4478 5 was be VBD cord-015021-pol2qm74 4478 6 to to TO cord-015021-pol2qm74 4478 7 investigate investigate VB cord-015021-pol2qm74 4478 8 which which WDT cord-015021-pol2qm74 4478 9 tissues tissue NNS cord-015021-pol2qm74 4478 10 damaged damage VBN cord-015021-pol2qm74 4478 11 during during IN cord-015021-pol2qm74 4478 12 the the DT cord-015021-pol2qm74 4478 13 procedure procedure NN cord-015021-pol2qm74 4478 14 of of IN cord-015021-pol2qm74 4478 15 limb limb NN cord-015021-pol2qm74 4478 16 transplantation transplantation NN cord-015021-pol2qm74 4478 17 may may MD cord-015021-pol2qm74 4478 18 be be VB cord-015021-pol2qm74 4478 19 a a DT cord-015021-pol2qm74 4478 20 potential potential JJ cord-015021-pol2qm74 4478 21 source source NN cord-015021-pol2qm74 4478 22 of of IN cord-015021-pol2qm74 4478 23 humoral humoral JJ cord-015021-pol2qm74 4478 24 factors factor NNS cord-015021-pol2qm74 4478 25 accelerating accelerate VBG cord-015021-pol2qm74 4478 26 in in IN cord-015021-pol2qm74 4478 27 vivo vivo NN cord-015021-pol2qm74 4478 28 bone bone NN cord-015021-pol2qm74 4478 29 marrow marrow NN cord-015021-pol2qm74 4478 30 proliferation proliferation NN cord-015021-pol2qm74 4478 31 . . . cord-015021-pol2qm74 4479 1 METHODS METHODS NNP cord-015021-pol2qm74 4479 2 . . . cord-015021-pol2qm74 4480 1 Experiments experiment NNS cord-015021-pol2qm74 4480 2 were be VBD cord-015021-pol2qm74 4480 3 carried carry VBN cord-015021-pol2qm74 4480 4 out out RP cord-015021-pol2qm74 4480 5 on on IN cord-015021-pol2qm74 4480 6 LEW LEW NNP cord-015021-pol2qm74 4480 7 rats rat NNS cord-015021-pol2qm74 4480 8 in in IN cord-015021-pol2qm74 4480 9 5 5 CD cord-015021-pol2qm74 4480 10 groups group NNS cord-015021-pol2qm74 4480 11 . . . cord-015021-pol2qm74 4481 1 In in IN cord-015021-pol2qm74 4481 2 group group NN cord-015021-pol2qm74 4481 3 I -PRON- PRP cord-015021-pol2qm74 4481 4 , , , cord-015021-pol2qm74 4481 5 the the DT cord-015021-pol2qm74 4481 6 hind hind NN cord-015021-pol2qm74 4481 7 limb limb NN cord-015021-pol2qm74 4481 8 was be VBD cord-015021-pol2qm74 4481 9 transplanted transplant VBN cord-015021-pol2qm74 4481 10 orthotopically orthotopically RB cord-015021-pol2qm74 4481 11 to to IN cord-015021-pol2qm74 4481 12 a a DT cord-015021-pol2qm74 4481 13 syngeneic syngeneic NNS cord-015021-pol2qm74 4481 14 recipient recipient NN cord-015021-pol2qm74 4481 15 ; ; : cord-015021-pol2qm74 4481 16 in in IN cord-015021-pol2qm74 4481 17 group group NN cord-015021-pol2qm74 4481 18 II II NNP cord-015021-pol2qm74 4481 19 , , , cord-015021-pol2qm74 4481 20 sham sham NN cord-015021-pol2qm74 4481 21 operation operation NN cord-015021-pol2qm74 4481 22 was be VBD cord-015021-pol2qm74 4481 23 performed perform VBN cord-015021-pol2qm74 4481 24 ; ; : cord-015021-pol2qm74 4481 25 in in IN cord-015021-pol2qm74 4481 26 group group NN cord-015021-pol2qm74 4481 27 III III NNP cord-015021-pol2qm74 4481 28 , , , cord-015021-pol2qm74 4481 29 a a DT cord-015021-pol2qm74 4481 30 four four CD cord-015021-pol2qm74 4481 31 - - HYPH cord-015021-pol2qm74 4481 32 cm cm NN cord-015021-pol2qm74 4481 33 long long JJ cord-015021-pol2qm74 4481 34 cutaneous cutaneous JJ cord-015021-pol2qm74 4481 35 wound wound NN cord-015021-pol2qm74 4481 36 was be VBD cord-015021-pol2qm74 4481 37 made make VBN cord-015021-pol2qm74 4481 38 on on IN cord-015021-pol2qm74 4481 39 the the DT cord-015021-pol2qm74 4481 40 dorsum dorsum NN cord-015021-pol2qm74 4481 41 ; ; : cord-015021-pol2qm74 4481 42 in in IN cord-015021-pol2qm74 4481 43 group group NN cord-015021-pol2qm74 4481 44 IV IV NNP cord-015021-pol2qm74 4481 45 , , , cord-015021-pol2qm74 4481 46 limb limb NN cord-015021-pol2qm74 4481 47 skin skin NN cord-015021-pol2qm74 4481 48 was be VBD cord-015021-pol2qm74 4481 49 harvested harvest VBN cord-015021-pol2qm74 4481 50 , , , cord-015021-pol2qm74 4481 51 fragmented fragmented JJ cord-015021-pol2qm74 4481 52 and and CC cord-015021-pol2qm74 4481 53 implanted implant VBN cord-015021-pol2qm74 4481 54 into into IN cord-015021-pol2qm74 4481 55 peritoneal peritoneal JJ cord-015021-pol2qm74 4481 56 cavity cavity NN cord-015021-pol2qm74 4481 57 ; ; : cord-015021-pol2qm74 4481 58 in in IN cord-015021-pol2qm74 4481 59 group group NN cord-015021-pol2qm74 4481 60 V v NN cord-015021-pol2qm74 4481 61 , , , cord-015021-pol2qm74 4481 62 BM BM NNP cord-015021-pol2qm74 4481 63 from from IN cord-015021-pol2qm74 4481 64 femur femur NN cord-015021-pol2qm74 4481 65 and and CC cord-015021-pol2qm74 4481 66 tibia tibia NN cord-015021-pol2qm74 4481 67 was be VBD cord-015021-pol2qm74 4481 68 implanted implant VBN cord-015021-pol2qm74 4481 69 intraperitoneally intraperitoneally RB cord-015021-pol2qm74 4481 70 . . . cord-015021-pol2qm74 4482 1 BM BM NNP cord-015021-pol2qm74 4482 2 , , , cord-015021-pol2qm74 4482 3 lymphoid lymphoid JJ cord-015021-pol2qm74 4482 4 tissues tissue NNS cord-015021-pol2qm74 4482 5 and and CC cord-015021-pol2qm74 4482 6 blood blood NN cord-015021-pol2qm74 4482 7 were be VBD cord-015021-pol2qm74 4482 8 sampled sample VBN cord-015021-pol2qm74 4482 9 10 10 CD cord-015021-pol2qm74 4482 10 and and CC cord-015021-pol2qm74 4482 11 30 30 CD cord-015021-pol2qm74 4482 12 days day NNS cord-015021-pol2qm74 4482 13 later later RB cord-015021-pol2qm74 4482 14 for for IN cord-015021-pol2qm74 4482 15 cell cell NN cord-015021-pol2qm74 4482 16 concentration concentration NN cord-015021-pol2qm74 4482 17 and and CC cord-015021-pol2qm74 4482 18 phenotype phenotype NN cord-015021-pol2qm74 4482 19 evaluation evaluation NN cord-015021-pol2qm74 4482 20 . . . cord-015021-pol2qm74 4483 1 RESULTS result NNS cord-015021-pol2qm74 4483 2 . . . cord-015021-pol2qm74 4484 1 The the DT cord-015021-pol2qm74 4484 2 yield yield NN cord-015021-pol2qm74 4484 3 of of IN cord-015021-pol2qm74 4484 4 nucleated nucleated JJ cord-015021-pol2qm74 4484 5 cells cell NNS cord-015021-pol2qm74 4484 6 from from IN cord-015021-pol2qm74 4484 7 tibia tibia NN cord-015021-pol2qm74 4484 8 was be VBD cord-015021-pol2qm74 4484 9 on on IN cord-015021-pol2qm74 4484 10 day day NN cord-015021-pol2qm74 4484 11 10 10 CD cord-015021-pol2qm74 4484 12 in in IN cord-015021-pol2qm74 4484 13 the the DT cord-015021-pol2qm74 4484 14 control control NN cord-015021-pol2qm74 4484 15 29.3 29.3 CD cord-015021-pol2qm74 4484 16 + + SYM cord-015021-pol2qm74 4484 17 3.2 3.2 CD cord-015021-pol2qm74 4484 18 , , , cord-015021-pol2qm74 4484 19 in in IN cord-015021-pol2qm74 4484 20 group group NN cord-015021-pol2qm74 4484 21 1 1 CD cord-015021-pol2qm74 4484 22 58.1 58.1 CD cord-015021-pol2qm74 4484 23 +2.0 +2.0 NNP cord-015021-pol2qm74 4484 24 , , , cord-015021-pol2qm74 4484 25 in in IN cord-015021-pol2qm74 4484 26 group group NN cord-015021-pol2qm74 4484 27 II II NNP cord-015021-pol2qm74 4484 28 47.1 47.1 CD cord-015021-pol2qm74 4484 29 + + SYM cord-015021-pol2qm74 4484 30 1.6 1.6 CD cord-015021-pol2qm74 4484 31 , , , cord-015021-pol2qm74 4484 32 in in IN cord-015021-pol2qm74 4484 33 group group NN cord-015021-pol2qm74 4484 34 III iii CD cord-015021-pol2qm74 4484 35 50.8 50.8 CD cord-015021-pol2qm74 4484 36 + + SYM cord-015021-pol2qm74 4484 37 2.0 2.0 CD cord-015021-pol2qm74 4484 38 , , , cord-015021-pol2qm74 4484 39 in in IN cord-015021-pol2qm74 4484 40 group group NN cord-015021-pol2qm74 4484 41 IV IV NNP cord-015021-pol2qm74 4484 42 48.5_+2.0 48.5_+2.0 CD cord-015021-pol2qm74 4484 43 , , , cord-015021-pol2qm74 4484 44 in in IN cord-015021-pol2qm74 4484 45 group group NN cord-015021-pol2qm74 4484 46 V v NN cord-015021-pol2qm74 4484 47 37.4_+4.9x10(6 37.4_+4.9x10(6 CD cord-015021-pol2qm74 4484 48 ) ) -RRB- cord-015021-pol2qm74 4484 49 . . . cord-015021-pol2qm74 4485 1 The the DT cord-015021-pol2qm74 4485 2 evident evident JJ cord-015021-pol2qm74 4485 3 increase increase NN cord-015021-pol2qm74 4485 4 in in IN cord-015021-pol2qm74 4485 5 BMC BMC NNP cord-015021-pol2qm74 4485 6 yield yield NN cord-015021-pol2qm74 4485 7 in in IN cord-015021-pol2qm74 4485 8 all all DT cord-015021-pol2qm74 4485 9 groups group NNS cord-015021-pol2qm74 4485 10 continued continue VBD cord-015021-pol2qm74 4485 11 until until IN cord-015021-pol2qm74 4485 12 day day NN cord-015021-pol2qm74 4485 13 30 30 CD cord-015021-pol2qm74 4485 14 . . . cord-015021-pol2qm74 4486 1 Increase increase VB cord-015021-pol2qm74 4486 2 in in IN cord-015021-pol2qm74 4486 3 weight weight NN cord-015021-pol2qm74 4486 4 and and CC cord-015021-pol2qm74 4486 5 total total JJ cord-015021-pol2qm74 4486 6 cell cell NN cord-015021-pol2qm74 4486 7 count count NN cord-015021-pol2qm74 4486 8 of of IN cord-015021-pol2qm74 4486 9 spleen spleen NNS cord-015021-pol2qm74 4486 10 and and CC cord-015021-pol2qm74 4486 11 mesenteric mesenteric JJ cord-015021-pol2qm74 4486 12 lymph lymph NN cord-015021-pol2qm74 4486 13 nodes node NNS cord-015021-pol2qm74 4486 14 in in IN cord-015021-pol2qm74 4486 15 all all DT cord-015021-pol2qm74 4486 16 but but CC cord-015021-pol2qm74 4486 17 group group NN cord-015021-pol2qm74 4486 18 III III NNP cord-015021-pol2qm74 4486 19 was be VBD cord-015021-pol2qm74 4486 20 also also RB cord-015021-pol2qm74 4486 21 found find VBN cord-015021-pol2qm74 4486 22 . . . cord-015021-pol2qm74 4487 1 No no DT cord-015021-pol2qm74 4487 2 differences difference NNS cord-015021-pol2qm74 4487 3 in in IN cord-015021-pol2qm74 4487 4 percentage percentage NN cord-015021-pol2qm74 4487 5 of of IN cord-015021-pol2qm74 4487 6 maturing mature VBG cord-015021-pol2qm74 4487 7 erythroid erythroid NN cord-015021-pol2qm74 4487 8 cells cell NNS cord-015021-pol2qm74 4487 9 , , , cord-015021-pol2qm74 4487 10 but but CC cord-015021-pol2qm74 4487 11 higher high JJR cord-015021-pol2qm74 4487 12 of of IN cord-015021-pol2qm74 4487 13 mature mature JJ cord-015021-pol2qm74 4487 14 myeloid myeloid NN cord-015021-pol2qm74 4487 15 cells cell NNS cord-015021-pol2qm74 4487 16 and and CC cord-015021-pol2qm74 4487 17 lower low JJR cord-015021-pol2qm74 4487 18 of of IN cord-015021-pol2qm74 4487 19 lymphocytes lymphocyte NNS cord-015021-pol2qm74 4487 20 were be VBD cord-015021-pol2qm74 4487 21 observed observe VBN cord-015021-pol2qm74 4487 22 . . . cord-015021-pol2qm74 4488 1 CONCLUSIONS conclusion NNS cord-015021-pol2qm74 4488 2 . . . cord-015021-pol2qm74 4489 1 Trauma trauma NN cord-015021-pol2qm74 4489 2 of of IN cord-015021-pol2qm74 4489 3 skin skin NN cord-015021-pol2qm74 4489 4 , , , cord-015021-pol2qm74 4489 5 muscles muscle NNS cord-015021-pol2qm74 4489 6 , , , cord-015021-pol2qm74 4489 7 and and CC cord-015021-pol2qm74 4489 8 bone bone NN cord-015021-pol2qm74 4489 9 brought bring VBD cord-015021-pol2qm74 4489 10 about about RP cord-015021-pol2qm74 4489 11 an an DT cord-015021-pol2qm74 4489 12 increase increase NN cord-015021-pol2qm74 4489 13 in in IN cord-015021-pol2qm74 4489 14 bone bone NN cord-015021-pol2qm74 4489 15 marrow marrow NN cord-015021-pol2qm74 4489 16 cellularity cellularity NN cord-015021-pol2qm74 4489 17 and and CC cord-015021-pol2qm74 4489 18 acceleration acceleration NN cord-015021-pol2qm74 4489 19 of of IN cord-015021-pol2qm74 4489 20 maturation maturation NN cord-015021-pol2qm74 4489 21 of of IN cord-015021-pol2qm74 4489 22 myeloid myeloid NN cord-015021-pol2qm74 4489 23 lineage lineage NN cord-015021-pol2qm74 4489 24 . . . cord-015021-pol2qm74 4490 1 Transplantation transplantation NN cord-015021-pol2qm74 4490 2 of of IN cord-015021-pol2qm74 4490 3 BM BM NNP cord-015021-pol2qm74 4490 4 ceils ceil NNS cord-015021-pol2qm74 4490 5 alone alone RB cord-015021-pol2qm74 4490 6 did do VBD cord-015021-pol2qm74 4490 7 not not RB cord-015021-pol2qm74 4490 8 produce produce VB cord-015021-pol2qm74 4490 9 this this DT cord-015021-pol2qm74 4490 10 effect effect NN cord-015021-pol2qm74 4490 11 . . . cord-015021-pol2qm74 4491 1 Transplantation transplantation NN cord-015021-pol2qm74 4491 2 of of IN cord-015021-pol2qm74 4491 3 BM BM NNP cord-015021-pol2qm74 4491 4 in in IN cord-015021-pol2qm74 4491 5 limb limb NN cord-015021-pol2qm74 4491 6 graft graft NN cord-015021-pol2qm74 4491 7 is be VBZ cord-015021-pol2qm74 4491 8 a a DT cord-015021-pol2qm74 4491 9 good good JJ cord-015021-pol2qm74 4491 10 model model NN cord-015021-pol2qm74 4491 11 for for IN cord-015021-pol2qm74 4491 12 studies study NNS cord-015021-pol2qm74 4491 13 of of IN cord-015021-pol2qm74 4491 14 natural natural JJ cord-015021-pol2qm74 4491 15 factors factor NNS cord-015021-pol2qm74 4491 16 reaulatin~ reaulatin~ VBP cord-015021-pol2qm74 4491 17 BM BM NNP cord-015021-pol2qm74 4491 18 hemormesis hemormesis NN cord-015021-pol2qm74 4491 19 . . . cord-015021-pol2qm74 4492 1 This this DT cord-015021-pol2qm74 4492 2 study study NN cord-015021-pol2qm74 4492 3 sought seek VBD cord-015021-pol2qm74 4492 4 to to TO cord-015021-pol2qm74 4492 5 determine determine VB cord-015021-pol2qm74 4492 6 a a DT cord-015021-pol2qm74 4492 7 relationship relationship NN cord-015021-pol2qm74 4492 8 , , , cord-015021-pol2qm74 4492 9 if if IN cord-015021-pol2qm74 4492 10 any any DT cord-015021-pol2qm74 4492 11 , , , cord-015021-pol2qm74 4492 12 between between IN cord-015021-pol2qm74 4492 13 the the DT cord-015021-pol2qm74 4492 14 degree degree NN cord-015021-pol2qm74 4492 15 of of IN cord-015021-pol2qm74 4492 16 hypochclesterolemia hypochclesterolemia NNP cord-015021-pol2qm74 4492 17 upon upon IN cord-015021-pol2qm74 4492 18 trauma trauma NN cord-015021-pol2qm74 4492 19 patients patient NNS cord-015021-pol2qm74 4492 20 ' ' POS cord-015021-pol2qm74 4492 21 admission admission NN cord-015021-pol2qm74 4492 22 and and CC cord-015021-pol2qm74 4492 23 their -PRON- PRP$ cord-015021-pol2qm74 4492 24 subsequent subsequent JJ cord-015021-pol2qm74 4492 25 outcome outcome NN cord-015021-pol2qm74 4492 26 . . . cord-015021-pol2qm74 4493 1 All all DT cord-015021-pol2qm74 4493 2 blunt blunt JJ cord-015021-pol2qm74 4493 3 and and CC cord-015021-pol2qm74 4493 4 penetrating penetrating JJ cord-015021-pol2qm74 4493 5 trauma trauma NN cord-015021-pol2qm74 4493 6 patients patient NNS cord-015021-pol2qm74 4493 7 admitted admit VBD cord-015021-pol2qm74 4493 8 to to IN cord-015021-pol2qm74 4493 9 a a DT cord-015021-pol2qm74 4493 10 Level level NN cord-015021-pol2qm74 4493 11 I -PRON- PRP cord-015021-pol2qm74 4493 12 facility facility NN cord-015021-pol2qm74 4493 13 from from IN cord-015021-pol2qm74 4493 14 1987 1987 CD cord-015021-pol2qm74 4493 15 through through IN cord-015021-pol2qm74 4493 16 1991 1991 CD cord-015021-pol2qm74 4493 17 , , , cord-015021-pol2qm74 4493 18 and and CC cord-015021-pol2qm74 4493 19 who who WP cord-015021-pol2qm74 4493 20 had have VBD cord-015021-pol2qm74 4493 21 serum serum NN cord-015021-pol2qm74 4493 22 cholesterol cholesterol NN cord-015021-pol2qm74 4493 23 assayed assay VBN cord-015021-pol2qm74 4493 24 during during IN cord-015021-pol2qm74 4493 25 the the DT cord-015021-pol2qm74 4493 26 first first JJ cord-015021-pol2qm74 4493 27 24 24 CD cord-015021-pol2qm74 4493 28 hrs hrs NN cord-015021-pol2qm74 4493 29 were be VBD cord-015021-pol2qm74 4493 30 retrospectively retrospectively RB cord-015021-pol2qm74 4493 31 studied study VBN cord-015021-pol2qm74 4493 32 for for IN cord-015021-pol2qm74 4493 33 development development NN cord-015021-pol2qm74 4493 34 of of IN cord-015021-pol2qm74 4493 35 death death NN cord-015021-pol2qm74 4493 36 or or CC cord-015021-pol2qm74 4493 37 significant significant JJ cord-015021-pol2qm74 4493 38 organ organ NN cord-015021-pol2qm74 4493 39 dysfunction dysfunction NN cord-015021-pol2qm74 4493 40 . . . cord-015021-pol2qm74 4494 1 The the DT cord-015021-pol2qm74 4494 2 Mantel Mantel NNP cord-015021-pol2qm74 4494 3 - - HYPH cord-015021-pol2qm74 4494 4 Kaenzel Kaenzel NNP cord-015021-pol2qm74 4494 5 chisquared chisquare VBD cord-015021-pol2qm74 4494 6 test test NN cord-015021-pol2qm74 4494 7 was be VBD cord-015021-pol2qm74 4494 8 used use VBN cord-015021-pol2qm74 4494 9 to to TO cord-015021-pol2qm74 4494 10 determine determine VB cord-015021-pol2qm74 4494 11 significance significance NN cord-015021-pol2qm74 4494 12 of of IN cord-015021-pol2qm74 4494 13 data datum NNS cord-015021-pol2qm74 4494 14 at at IN cord-015021-pol2qm74 4494 15 the the DT cord-015021-pol2qm74 4494 16 p p NN cord-015021-pol2qm74 4494 17 < < XX cord-015021-pol2qm74 4494 18 0.05 0.05 CD cord-015021-pol2qm74 4494 19 level level NN cord-015021-pol2qm74 4494 20 . . . cord-015021-pol2qm74 4495 1 RESULTS result NNS cord-015021-pol2qm74 4495 2 : : : cord-015021-pol2qm74 4496 1 2909 2909 CD cord-015021-pol2qm74 4496 2 trauma trauma NN cord-015021-pol2qm74 4496 3 patients patient NNS cord-015021-pol2qm74 4496 4 were be VBD cord-015021-pol2qm74 4496 5 admitted admit VBN cord-015021-pol2qm74 4496 6 during during IN cord-015021-pol2qm74 4496 7 the the DT cord-015021-pol2qm74 4496 8 four four CD cord-015021-pol2qm74 4496 9 - - HYPH cord-015021-pol2qm74 4496 10 year year NN cord-015021-pol2qm74 4496 11 period period NN cord-015021-pol2qm74 4496 12 who who WP cord-015021-pol2qm74 4496 13 had have VBD cord-015021-pol2qm74 4496 14 serum serum NN cord-015021-pol2qm74 4496 15 cholesterol cholesterol NN cord-015021-pol2qm74 4496 16 assays assay NNS cord-015021-pol2qm74 4496 17 performed perform VBN cord-015021-pol2qm74 4496 18 in in IN cord-015021-pol2qm74 4496 19 the the DT cord-015021-pol2qm74 4496 20 first first JJ cord-015021-pol2qm74 4496 21 24 24 CD cord-015021-pol2qm74 4496 22 hrs hrs NN cord-015021-pol2qm74 4496 23 . . . cord-015021-pol2qm74 4497 1 24 24 CD cord-015021-pol2qm74 4497 2 patients patient NNS cord-015021-pol2qm74 4497 3 had have VBD cord-015021-pol2qm74 4497 4 cholesterol cholesterol NN cord-015021-pol2qm74 4497 5 levels level NNS cord-015021-pol2qm74 4497 6 less less JJR cord-015021-pol2qm74 4497 7 than than IN cord-015021-pol2qm74 4497 8 50 50 CD cord-015021-pol2qm74 4497 9 mg mg NNP cord-015021-pol2qm74 4497 10 / / SYM cord-015021-pol2qm74 4497 11 dl dl NN cord-015021-pol2qm74 4497 12 ; ; : cord-015021-pol2qm74 4497 13 8 8 CD cord-015021-pol2qm74 4497 14 of of IN cord-015021-pol2qm74 4497 15 these these DT cord-015021-pol2qm74 4497 16 ( ( -LRB- cord-015021-pol2qm74 4497 17 33.3 33.3 CD cord-015021-pol2qm74 4497 18 % % NN cord-015021-pol2qm74 4497 19 ) ) -RRB- cord-015021-pol2qm74 4497 20 died die VBD cord-015021-pol2qm74 4497 21 , , , cord-015021-pol2qm74 4497 22 3 3 CD cord-015021-pol2qm74 4497 23 ( ( -LRB- cord-015021-pol2qm74 4497 24 12.5 12.5 CD cord-015021-pol2qm74 4497 25 % % NN cord-015021-pol2qm74 4497 26 ) ) -RRB- cord-015021-pol2qm74 4497 27 developed develop VBD cord-015021-pol2qm74 4497 28 ARDS ARDS NNP cord-015021-pol2qm74 4497 29 , , , cord-015021-pol2qm74 4497 30 5 5 CD cord-015021-pol2qm74 4497 31 ( ( -LRB- cord-015021-pol2qm74 4497 32 20.8 20.8 CD cord-015021-pol2qm74 4497 33 % % NN cord-015021-pol2qm74 4497 34 ) ) -RRB- cord-015021-pol2qm74 4497 35 developed develop VBN cord-015021-pol2qm74 4497 36 acute acute JJ cord-015021-pol2qm74 4497 37 renal renal JJ cord-015021-pol2qm74 4497 38 failure failure NN cord-015021-pol2qm74 4497 39 , , , cord-015021-pol2qm74 4497 40 and and CC cord-015021-pol2qm74 4497 41 8 8 CD cord-015021-pol2qm74 4497 42 ( ( -LRB- cord-015021-pol2qm74 4497 43 33.3 33.3 CD cord-015021-pol2qm74 4497 44 % % NN cord-015021-pol2qm74 4497 45 ) ) -RRB- cord-015021-pol2qm74 4497 46 developed develop VBN cord-015021-pol2qm74 4497 47 multisystem multisystem JJ cord-015021-pol2qm74 4497 48 organ organ NN cord-015021-pol2qm74 4497 49 dysfunction dysfunction NN cord-015021-pol2qm74 4497 50 ; ; : cord-015021-pol2qm74 4497 51 hypocholesterolemia hypocholesterolemia NN cord-015021-pol2qm74 4497 52 in in IN cord-015021-pol2qm74 4497 53 these these DT cord-015021-pol2qm74 4497 54 patients patient NNS cord-015021-pol2qm74 4497 55 was be VBD cord-015021-pol2qm74 4497 56 not not RB cord-015021-pol2qm74 4497 57 due due JJ cord-015021-pol2qm74 4497 58 to to IN cord-015021-pol2qm74 4497 59 liver liver NN cord-015021-pol2qm74 4497 60 injury injury NN cord-015021-pol2qm74 4497 61 or or CC cord-015021-pol2qm74 4497 62 massive massive JJ cord-015021-pol2qm74 4497 63 fluid fluid JJ cord-015021-pol2qm74 4497 64 administration administration NN cord-015021-pol2qm74 4497 65 . . . cord-015021-pol2qm74 4498 1 The the DT cord-015021-pol2qm74 4498 2 risk risk NN cord-015021-pol2qm74 4498 3 of of IN cord-015021-pol2qm74 4498 4 death death NN cord-015021-pol2qm74 4498 5 was be VBD cord-015021-pol2qm74 4498 6 5 5 CD cord-015021-pol2qm74 4498 7 times time NNS cord-015021-pol2qm74 4498 8 greater great JJR cord-015021-pol2qm74 4498 9 and and CC cord-015021-pol2qm74 4498 10 risk risk NN cord-015021-pol2qm74 4498 11 of of IN cord-015021-pol2qm74 4498 12 multi multi JJ cord-015021-pol2qm74 4498 13 - - JJ cord-015021-pol2qm74 4498 14 organ organ JJ cord-015021-pol2qm74 4498 15 failure failure NN cord-015021-pol2qm74 4498 16 3 3 CD cord-015021-pol2qm74 4498 17 times time NNS cord-015021-pol2qm74 4498 18 greater great JJR cord-015021-pol2qm74 4498 19 in in IN cord-015021-pol2qm74 4498 20 this this DT cord-015021-pol2qm74 4498 21 group group NN cord-015021-pol2qm74 4498 22 than than IN cord-015021-pol2qm74 4498 23 in in IN cord-015021-pol2qm74 4498 24 those those DT cord-015021-pol2qm74 4498 25 with with IN cord-015021-pol2qm74 4498 26 a a DT cord-015021-pol2qm74 4498 27 normal normal JJ cord-015021-pol2qm74 4498 28 serum serum NN cord-015021-pol2qm74 4498 29 cholesterol cholesterol NN cord-015021-pol2qm74 4498 30 ( ( -LRB- cord-015021-pol2qm74 4498 31 > > XX cord-015021-pol2qm74 4499 1 if0 if0 NNP cord-015021-pol2qm74 4499 2 mg mg NNP cord-015021-pol2qm74 4499 3 / / SYM cord-015021-pol2qm74 4499 4 dl dl NN cord-015021-pol2qm74 4499 5 ; ; : cord-015021-pol2qm74 4500 1 1820 1820 CD cord-015021-pol2qm74 4500 2 patients patient NNS cord-015021-pol2qm74 4500 3 ; ; : cord-015021-pol2qm74 4500 4 p<0.05 p<0.05 CD cord-015021-pol2qm74 4500 5 ) ) -RRB- cord-015021-pol2qm74 4500 6 . . . cord-015021-pol2qm74 4501 1 CONCLUSIONS conclusion NNS cord-015021-pol2qm74 4501 2 : : : cord-015021-pol2qm74 4502 1 Admission admission NN cord-015021-pol2qm74 4502 2 serum serum NN cord-015021-pol2qm74 4502 3 cholesterol cholesterol NN cord-015021-pol2qm74 4502 4 level level NN cord-015021-pol2qm74 4502 5 in in IN cord-015021-pol2qm74 4502 6 the the DT cord-015021-pol2qm74 4502 7 trauma trauma NN cord-015021-pol2qm74 4502 8 patient patient NN cord-015021-pol2qm74 4502 9 serves serve VBZ cord-015021-pol2qm74 4502 10 as as IN cord-015021-pol2qm74 4502 11 a a DT cord-015021-pol2qm74 4502 12 powerful powerful JJ cord-015021-pol2qm74 4502 13 marker marker NN cord-015021-pol2qm74 4502 14 for for IN cord-015021-pol2qm74 4502 15 those those DT cord-015021-pol2qm74 4502 16 at at IN cord-015021-pol2qm74 4502 17 risk risk NN cord-015021-pol2qm74 4502 18 of of IN cord-015021-pol2qm74 4502 19 subsequent subsequent JJ cord-015021-pol2qm74 4502 20 organ organ NN cord-015021-pol2qm74 4502 21 failure failure NN cord-015021-pol2qm74 4502 22 or or CC cord-015021-pol2qm74 4502 23 death death NN cord-015021-pol2qm74 4502 24 . . . cord-015021-pol2qm74 4503 1 Hypocholesterolemia Hypocholesterolemia NNP cord-015021-pol2qm74 4503 2 in in IN cord-015021-pol2qm74 4503 3 this this DT cord-015021-pol2qm74 4503 4 setting setting NN cord-015021-pol2qm74 4503 5 may may MD cord-015021-pol2qm74 4503 6 result result VB cord-015021-pol2qm74 4503 7 from from IN cord-015021-pol2qm74 4503 8 organ organ NN cord-015021-pol2qm74 4503 9 hypoperfusion hypoperfusion NN cord-015021-pol2qm74 4503 10 and and CC cord-015021-pol2qm74 4503 11 humeral humeral JJ cord-015021-pol2qm74 4503 12 mediator mediator NN cord-015021-pol2qm74 4503 13 release release NN cord-015021-pol2qm74 4503 14 . . . cord-015021-pol2qm74 4504 1 Lung lung NN cord-015021-pol2qm74 4504 2 tissue tissue NN cord-015021-pol2qm74 4504 3 contains contain VBZ cord-015021-pol2qm74 4504 4 many many JJ cord-015021-pol2qm74 4504 5 immunocompetent immunocompetent JJ cord-015021-pol2qm74 4504 6 cells cell NNS cord-015021-pol2qm74 4504 7 . . . cord-015021-pol2qm74 4505 1 Resection resection NN cord-015021-pol2qm74 4505 2 , , , cord-015021-pol2qm74 4505 3 therefore therefore RB cord-015021-pol2qm74 4505 4 , , , cord-015021-pol2qm74 4505 5 is be VBZ cord-015021-pol2qm74 4505 6 expected expect VBN cord-015021-pol2qm74 4505 7 to to TO cord-015021-pol2qm74 4505 8 activate activate VB cord-015021-pol2qm74 4505 9 extensively extensively RB cord-015021-pol2qm74 4505 10 inflammatory inflammatory JJ cord-015021-pol2qm74 4505 11 mediators mediator NNS cord-015021-pol2qm74 4505 12 such such JJ cord-015021-pol2qm74 4505 13 as as IN cord-015021-pol2qm74 4505 14 PMN pmn NN cord-015021-pol2qm74 4505 15 - - HYPH cord-015021-pol2qm74 4505 16 elastase elastase NN cord-015021-pol2qm74 4505 17 , , , cord-015021-pol2qm74 4505 18 pmstanoids pmstanoid NNS cord-015021-pol2qm74 4505 19 and and CC cord-015021-pol2qm74 4505 20 pteridines pteridine NNS cord-015021-pol2qm74 4505 21 . . . cord-015021-pol2qm74 4506 1 In in IN cord-015021-pol2qm74 4506 2 a a DT cord-015021-pol2qm74 4506 3 prospective prospective JJ cord-015021-pol2qm74 4506 4 clinical clinical JJ cord-015021-pol2qm74 4506 5 study study NN cord-015021-pol2qm74 4506 6 we -PRON- PRP cord-015021-pol2qm74 4506 7 compared compare VBD cord-015021-pol2qm74 4506 8 35 35 CD cord-015021-pol2qm74 4506 9 patients patient NNS cord-015021-pol2qm74 4506 10 ( ( -LRB- cord-015021-pol2qm74 4506 11 pts pts NN cord-015021-pol2qm74 4506 12 ) ) -RRB- cord-015021-pol2qm74 4506 13 undergoing undergo VBG cord-015021-pol2qm74 4506 14 either either CC cord-015021-pol2qm74 4506 15 thomcotomy thomcotomy NN cord-015021-pol2qm74 4506 16 with with IN cord-015021-pol2qm74 4506 17 or or CC cord-015021-pol2qm74 4506 18 without without IN cord-015021-pol2qm74 4506 19 lung lung NN cord-015021-pol2qm74 4506 20 tissue tissue NN cord-015021-pol2qm74 4506 21 msectioh msectioh NNP cord-015021-pol2qm74 4506 22 and and CC cord-015021-pol2qm74 4506 23 tboracoscopic tboracoscopic NNP cord-015021-pol2qm74 4506 24 lung lung NN cord-015021-pol2qm74 4506 25 resection resection NN cord-015021-pol2qm74 4506 26 concerning concern VBG cord-015021-pol2qm74 4506 27 activation activation NN cord-015021-pol2qm74 4506 28 of of IN cord-015021-pol2qm74 4506 29 inflammatory inflammatory JJ cord-015021-pol2qm74 4506 30 response response NN cord-015021-pol2qm74 4506 31 . . . cord-015021-pol2qm74 4507 1 Material Material NNP cord-015021-pol2qm74 4507 2 & & CC cord-015021-pol2qm74 4507 3 Methods Methods NNPS cord-015021-pol2qm74 4507 4 : : : cord-015021-pol2qm74 4507 5 Group Group NNP cord-015021-pol2qm74 4507 6 A A NNP cord-015021-pol2qm74 4507 7 pts pts NN cord-015021-pol2qm74 4507 8 ( ( -LRB- cord-015021-pol2qm74 4507 9 n=8 n=8 NN cord-015021-pol2qm74 4507 10 ) ) -RRB- cord-015021-pol2qm74 4507 11 had have VBD cord-015021-pol2qm74 4507 12 thoraantomy thoraantomy NN cord-015021-pol2qm74 4507 13 but but CC cord-015021-pol2qm74 4507 14 no no DT cord-015021-pol2qm74 4507 15 lung lung NN cord-015021-pol2qm74 4507 16 tissue tissue NN cord-015021-pol2qm74 4507 17 injury injury NN cord-015021-pol2qm74 4507 18 ; ; : cord-015021-pol2qm74 4507 19 group group NN cord-015021-pol2qm74 4507 20 B b NN cord-015021-pol2qm74 4507 21 pts pts NNP cord-015021-pol2qm74 4507 22 ( ( -LRB- cord-015021-pol2qm74 4507 23 n n NN cord-015021-pol2qm74 4507 24 = = NN cord-015021-pol2qm74 4507 25 lS ls NN cord-015021-pol2qm74 4507 26 ) ) -RRB- cord-015021-pol2qm74 4507 27 had have VBD cord-015021-pol2qm74 4507 28 thoracotomy thoracotomy NN cord-015021-pol2qm74 4507 29 and and CC cord-015021-pol2qm74 4507 30 lung lung NN cord-015021-pol2qm74 4507 31 tissue tissue NN cord-015021-pol2qm74 4507 32 resection resection NN cord-015021-pol2qm74 4507 33 due due IN cord-015021-pol2qm74 4507 34 to to IN cord-015021-pol2qm74 4507 35 benign benign JJ cord-015021-pol2qm74 4507 36 diseases disease NNS cord-015021-pol2qm74 4507 37 ; ; : cord-015021-pol2qm74 4507 38 group group NN cord-015021-pol2qm74 4507 39 C C NNP cord-015021-pol2qm74 4507 40 ( ( -LRB- cord-015021-pol2qm74 4507 41 n=9 n=9 NN cord-015021-pol2qm74 4507 42 ) ) -RRB- cord-015021-pol2qm74 4507 43 represents represent VBZ cord-015021-pol2qm74 4507 44 group group NN cord-015021-pol2qm74 4507 45 B B NNP cord-015021-pol2qm74 4507 46 tissue tissue NN cord-015021-pol2qm74 4507 47 resection resection NN cord-015021-pol2qm74 4507 48 but but CC cord-015021-pol2qm74 4507 49 using use VBG cord-015021-pol2qm74 4507 50 a a DT cord-015021-pol2qm74 4507 51 thomcoscopic thomcoscopic JJ cord-015021-pol2qm74 4507 52 procedure procedure NN cord-015021-pol2qm74 4507 53 . . . cord-015021-pol2qm74 4508 1 The the DT cord-015021-pol2qm74 4508 2 following following JJ cord-015021-pol2qm74 4508 3 parameters parameter NNS cord-015021-pol2qm74 4508 4 were be VBD cord-015021-pol2qm74 4508 5 determined determine VBN cord-015021-pol2qm74 4508 6 pre- pre- JJ cord-015021-pol2qm74 4508 7 , , , cord-015021-pol2qm74 4508 8 peri- peri- JJ cord-015021-pol2qm74 4508 9 , , , cord-015021-pol2qm74 4508 10 and and CC cord-015021-pol2qm74 4508 11 postoperatively postoperatively RB cord-015021-pol2qm74 4508 12 : : : cord-015021-pol2qm74 4509 1 Elastase Elastase NNP cord-015021-pol2qm74 4509 2 and and CC cord-015021-pol2qm74 4509 3 CRP CRP NNP cord-015021-pol2qm74 4509 4 as as IN cord-015021-pol2qm74 4509 5 indicators indicator NNS cord-015021-pol2qm74 4509 6 of of IN cord-015021-pol2qm74 4509 7 activation activation NN cord-015021-pol2qm74 4509 8 of of IN cord-015021-pol2qm74 4509 9 PMN pmn NN cord-015021-pol2qm74 4509 10 - - HYPH cord-015021-pol2qm74 4509 11 leukocytes leukocyte NNS cord-015021-pol2qm74 4509 12 and and CC cord-015021-pol2qm74 4509 13 injury injury NN cord-015021-pol2qm74 4509 14 severity severity NN cord-015021-pol2qm74 4509 15 ; ; : cord-015021-pol2qm74 4509 16 prostacyclin prostacyclin NNP cord-015021-pol2qm74 4509 17 ( ( -LRB- cord-015021-pol2qm74 4509 18 PGI PGI NNP cord-015021-pol2qm74 4509 19 2 2 CD cord-015021-pol2qm74 4509 20 ) ) -RRB- cord-015021-pol2qm74 4509 21 and and CC cord-015021-pol2qm74 4509 22 thromboxane thromboxane NN cord-015021-pol2qm74 4509 23 ( ( -LRB- cord-015021-pol2qm74 4509 24 TXA~ TXA~ NNP cord-015021-pol2qm74 4509 25 ) ) -RRB- cord-015021-pol2qm74 4509 26 as as IN cord-015021-pol2qm74 4509 27 parameters parameter NNS cord-015021-pol2qm74 4509 28 of of IN cord-015021-pol2qm74 4509 29 lung lung NN cord-015021-pol2qm74 4509 30 endothelial endothelial JJ cord-015021-pol2qm74 4509 31 response response NN cord-015021-pol2qm74 4509 32 ; ; : cord-015021-pol2qm74 4509 33 prostaglandin prostaglandin NN cord-015021-pol2qm74 4509 34 F2~ F2~ NNP cord-015021-pol2qm74 4509 35 ( ( -LRB- cord-015021-pol2qm74 4509 36 PGF~ pgf~ NN cord-015021-pol2qm74 4509 37 ) ) -RRB- cord-015021-pol2qm74 4509 38 and and CC cord-015021-pol2qm74 4509 39 PGM PGM NNP cord-015021-pol2qm74 4509 40 representing represent VBG cord-015021-pol2qm74 4509 41 pulmonaly pulmonaly NNP cord-015021-pol2qm74 4509 42 metabolic metabolic JJ cord-015021-pol2qm74 4509 43 activity activity NN cord-015021-pol2qm74 4509 44 ; ; : cord-015021-pol2qm74 4509 45 PGE PGE NNP cord-015021-pol2qm74 4509 46 a a NNP cord-015021-pol2qm74 4509 47 and and CC cord-015021-pol2qm74 4509 48 neopterin neopterin NN cord-015021-pol2qm74 4509 49 as as IN cord-015021-pol2qm74 4509 50 proof proof NN cord-015021-pol2qm74 4509 51 of of IN cord-015021-pol2qm74 4509 52 macmphage macmphage NNP cord-015021-pol2qm74 4509 53 activation activation NN cord-015021-pol2qm74 4509 54 . . . cord-015021-pol2qm74 4510 1 Statistics statistic NNS cord-015021-pol2qm74 4510 2 were be VBD cord-015021-pol2qm74 4510 3 performed perform VBN cord-015021-pol2qm74 4510 4 using use VBG cord-015021-pol2qm74 4510 5 analysis analysis NN cord-015021-pol2qm74 4510 6 of of IN cord-015021-pol2qm74 4510 7 variance variance NN cord-015021-pol2qm74 4510 8 for for IN cord-015021-pol2qm74 4510 9 repeated repeat VBN cord-015021-pol2qm74 4510 10 measures measure NNS cord-015021-pol2qm74 4510 11 . . . cord-015021-pol2qm74 4511 1 Results result NNS cord-015021-pol2qm74 4511 2 : : : cord-015021-pol2qm74 4512 1 Group Group NNP cord-015021-pol2qm74 4512 2 B B NNP cord-015021-pol2qm74 4512 3 pts pts NNP cord-015021-pol2qm74 4512 4 revealed reveal VBD cord-015021-pol2qm74 4512 5 postoperatively postoperatively RB cord-015021-pol2qm74 4512 6 an an DT cord-015021-pol2qm74 4512 7 increase increase NN cord-015021-pol2qm74 4512 8 in in IN cord-015021-pol2qm74 4512 9 CRP CRP NNP cord-015021-pol2qm74 4512 10 ( ( -LRB- cord-015021-pol2qm74 4512 11 p<0.001 p<0.001 CD cord-015021-pol2qm74 4512 12 ) ) -RRB- cord-015021-pol2qm74 4512 13 indicating indicate VBG cord-015021-pol2qm74 4512 14 a a DT cord-015021-pol2qm74 4512 15 higher high JJR cord-015021-pol2qm74 4512 16 injury injury NN cord-015021-pol2qm74 4512 17 severity severity NN cord-015021-pol2qm74 4512 18 in in IN cord-015021-pol2qm74 4512 19 comparison comparison NN cord-015021-pol2qm74 4512 20 to to IN cord-015021-pol2qm74 4512 21 the the DT cord-015021-pol2qm74 4512 22 thoracoscopic thoracoscopic NNP cord-015021-pol2qm74 4512 23 procedure procedure NN cord-015021-pol2qm74 4512 24 ( ( -LRB- cord-015021-pol2qm74 4512 25 C C NNP cord-015021-pol2qm74 4512 26 ) ) -RRB- cord-015021-pol2qm74 4512 27 . . . cord-015021-pol2qm74 4513 1 Both both DT cord-015021-pol2qm74 4513 2 , , , cord-015021-pol2qm74 4513 3 controls control VBZ cord-015021-pol2qm74 4513 4 ( ( -LRB- cord-015021-pol2qm74 4513 5 A a NN cord-015021-pol2qm74 4513 6 ) ) -RRB- cord-015021-pol2qm74 4513 7 and and CC cord-015021-pol2qm74 4513 8 group group NN cord-015021-pol2qm74 4513 9 C C NNP cord-015021-pol2qm74 4513 10 pts pts NNP cord-015021-pol2qm74 4513 11 did do VBD cord-015021-pol2qm74 4513 12 not not RB cord-015021-pol2qm74 4513 13 show show VB cord-015021-pol2qm74 4513 14 PMN PMN NNP cord-015021-pol2qm74 4513 15 - - HYPH cord-015021-pol2qm74 4513 16 activation activation NN cord-015021-pol2qm74 4513 17 , , , cord-015021-pol2qm74 4513 18 whereas whereas IN cord-015021-pol2qm74 4513 19 group group NN cord-015021-pol2qm74 4513 20 B B NNP cord-015021-pol2qm74 4513 21 demonstrated demonstrate VBD cord-015021-pol2qm74 4513 22 a a DT cord-015021-pol2qm74 4513 23 reversible reversible JJ cord-015021-pol2qm74 4513 24 increase increase NN cord-015021-pol2qm74 4513 25 in in IN cord-015021-pol2qm74 4513 26 elastase elastase NN cord-015021-pol2qm74 4513 27 . . . cord-015021-pol2qm74 4514 1 Surgical surgical JJ cord-015021-pol2qm74 4514 2 trauma trauma NN cord-015021-pol2qm74 4514 3 caused cause VBN cord-015021-pol2qm74 4514 4 in in IN cord-015021-pol2qm74 4514 5 all all DT cord-015021-pol2qm74 4514 6 groups group NNS cord-015021-pol2qm74 4514 7 a a DT cord-015021-pol2qm74 4514 8 release release NN cord-015021-pol2qm74 4514 9 of of IN cord-015021-pol2qm74 4514 10 PGI PGI NNP cord-015021-pol2qm74 4514 11 z z NNP cord-015021-pol2qm74 4514 12 and and CC cord-015021-pol2qm74 4514 13 TXA TXA NNP cord-015021-pol2qm74 4514 14 2 2 CD cord-015021-pol2qm74 4514 15 which which WDT cord-015021-pol2qm74 4514 16 was be VBD cord-015021-pol2qm74 4514 17 more more RBR cord-015021-pol2qm74 4514 18 pronounced pronounced JJ cord-015021-pol2qm74 4514 19 in in IN cord-015021-pol2qm74 4514 20 C C NNP cord-015021-pol2qm74 4514 21 ( ( -LRB- cord-015021-pol2qm74 4514 22 p<0.05 p<0.05 NNP cord-015021-pol2qm74 4514 23 ) ) -RRB- cord-015021-pol2qm74 4514 24 and and CC cord-015021-pol2qm74 4514 25 most most JJS cord-015021-pol2qm74 4514 26 in in IN cord-015021-pol2qm74 4514 27 B B NNP cord-015021-pol2qm74 4514 28 ( ( -LRB- cord-015021-pol2qm74 4514 29 p<0.01 p<0.01 NNP cord-015021-pol2qm74 4514 30 ) ) -RRB- cord-015021-pol2qm74 4514 31 . . . cord-015021-pol2qm74 4515 1 Similar similar JJ cord-015021-pol2qm74 4515 2 results result NNS cord-015021-pol2qm74 4515 3 were be VBD cord-015021-pol2qm74 4515 4 found find VBN cord-015021-pol2qm74 4515 5 for for IN cord-015021-pol2qm74 4515 6 PGE~ PGE~ NNS cord-015021-pol2qm74 4516 1 and and CC cord-015021-pol2qm74 4516 2 PGF2=. PGF2=. NNP cord-015021-pol2qm74 4516 3 There there EX cord-015021-pol2qm74 4516 4 was be VBD cord-015021-pol2qm74 4516 5 no no DT cord-015021-pol2qm74 4516 6 activation activation NN cord-015021-pol2qm74 4516 7 of of IN cord-015021-pol2qm74 4516 8 maerophages maerophage NNS cord-015021-pol2qm74 4516 9 since since IN cord-015021-pol2qm74 4516 10 neopterin neopterin NNP cord-015021-pol2qm74 4516 11 did do VBD cord-015021-pol2qm74 4516 12 not not RB cord-015021-pol2qm74 4516 13 increase increase VB cord-015021-pol2qm74 4516 14 . . . cord-015021-pol2qm74 4517 1 Apparently apparently RB cord-015021-pol2qm74 4517 2 , , , cord-015021-pol2qm74 4517 3 metabolic metabolic JJ cord-015021-pol2qm74 4517 4 lung lung NN cord-015021-pol2qm74 4517 5 function function NN cord-015021-pol2qm74 4517 6 was be VBD cord-015021-pol2qm74 4517 7 not not RB cord-015021-pol2qm74 4517 8 impaired impaired JJ cord-015021-pol2qm74 4517 9 because because IN cord-015021-pol2qm74 4517 10 there there EX cord-015021-pol2qm74 4517 11 was be VBD cord-015021-pol2qm74 4517 12 no no DT cord-015021-pol2qm74 4517 13 marked marked JJ cord-015021-pol2qm74 4517 14 rise rise NN cord-015021-pol2qm74 4517 15 in in IN cord-015021-pol2qm74 4517 16 PGM PGM NNP cord-015021-pol2qm74 4517 17 except except IN cord-015021-pol2qm74 4517 18 in in IN cord-015021-pol2qm74 4517 19 B b NN cord-015021-pol2qm74 4517 20 ( ( -LRB- cord-015021-pol2qm74 4517 21 p<0.05 p<0.05 NNP cord-015021-pol2qm74 4517 22 vs. vs. FW cord-015021-pol2qm74 4517 23 C C NNP cord-015021-pol2qm74 4517 24 ) ) -RRB- cord-015021-pol2qm74 4517 25 . . . cord-015021-pol2qm74 4518 1 Discussion discussion NN cord-015021-pol2qm74 4518 2 : : : cord-015021-pol2qm74 4519 1 Our -PRON- PRP$ cord-015021-pol2qm74 4519 2 results result NNS cord-015021-pol2qm74 4519 3 demonstrate demonstrate VBP cord-015021-pol2qm74 4519 4 that that IN cord-015021-pol2qm74 4519 5 lung lung NN cord-015021-pol2qm74 4519 6 tissue tissue NN cord-015021-pol2qm74 4519 7 injury injury NN cord-015021-pol2qm74 4519 8 aggravates aggravate VBZ cord-015021-pol2qm74 4519 9 the the DT cord-015021-pol2qm74 4519 10 mediator mediator NN cord-015021-pol2qm74 4519 11 release release NN cord-015021-pol2qm74 4519 12 induced induce VBN cord-015021-pol2qm74 4519 13 by by IN cord-015021-pol2qm74 4519 14 thoracic thoracic JJ cord-015021-pol2qm74 4519 15 traum traum NNP cord-015021-pol2qm74 4519 16 . . . cord-015021-pol2qm74 4520 1 These these DT cord-015021-pol2qm74 4520 2 mediators mediator NNS cord-015021-pol2qm74 4520 3 among among IN cord-015021-pol2qm74 4520 4 others other NNS cord-015021-pol2qm74 4520 5 are be VBP cord-015021-pol2qm74 4520 6 able able JJ cord-015021-pol2qm74 4520 7 to to TO cord-015021-pol2qm74 4520 8 increase increase VB cord-015021-pol2qm74 4520 9 capillary capillary JJ cord-015021-pol2qm74 4520 10 pressure pressure NN cord-015021-pol2qm74 4520 11 and and CC cord-015021-pol2qm74 4520 12 hence hence RB cord-015021-pol2qm74 4520 13 lung lung NN cord-015021-pol2qm74 4520 14 edema edema NN cord-015021-pol2qm74 4520 15 formation formation NN cord-015021-pol2qm74 4520 16 . . . cord-015021-pol2qm74 4521 1 Impairment impairment NN cord-015021-pol2qm74 4521 2 of of IN cord-015021-pol2qm74 4521 3 lung lung NN cord-015021-pol2qm74 4521 4 function function NN cord-015021-pol2qm74 4521 5 , , , cord-015021-pol2qm74 4521 6 however however RB cord-015021-pol2qm74 4521 7 , , , cord-015021-pol2qm74 4521 8 seems seem VBZ cord-015021-pol2qm74 4521 9 dependent dependent JJ cord-015021-pol2qm74 4521 10 on on IN cord-015021-pol2qm74 4521 11 the the DT cord-015021-pol2qm74 4521 12 extent extent NN cord-015021-pol2qm74 4521 13 of of IN cord-015021-pol2qm74 4521 14 the the DT cord-015021-pol2qm74 4521 15 liberation liberation NN cord-015021-pol2qm74 4521 16 . . . cord-015021-pol2qm74 4522 1 Therefore therefore RB cord-015021-pol2qm74 4522 2 , , , cord-015021-pol2qm74 4522 3 the the DT cord-015021-pol2qm74 4522 4 maximal maximal JJ cord-015021-pol2qm74 4522 5 release release NN cord-015021-pol2qm74 4522 6 reactions reaction NNS cord-015021-pol2qm74 4522 7 occured occur VBD cord-015021-pol2qm74 4522 8 in in IN cord-015021-pol2qm74 4522 9 group group NN cord-015021-pol2qm74 4522 10 B B NNP cord-015021-pol2qm74 4522 11 and and CC cord-015021-pol2qm74 4522 12 C C NNP cord-015021-pol2qm74 4522 13 after after IN cord-015021-pol2qm74 4522 14 lung lung NN cord-015021-pol2qm74 4522 15 tissue tissue NN cord-015021-pol2qm74 4522 16 resection resection NN cord-015021-pol2qm74 4522 17 , , , cord-015021-pol2qm74 4522 18 whereas whereas IN cord-015021-pol2qm74 4522 19 the the DT cord-015021-pol2qm74 4522 20 controls control NNS cord-015021-pol2qm74 4522 21 showed show VBD cord-015021-pol2qm74 4522 22 the the DT cord-015021-pol2qm74 4522 23 highest high JJS cord-015021-pol2qm74 4522 24 levels level NNS cord-015021-pol2qm74 4522 25 immediately immediately RB cord-015021-pol2qm74 4522 26 after after IN cord-015021-pol2qm74 4522 27 the the DT cord-015021-pol2qm74 4522 28 incision incision NN cord-015021-pol2qm74 4522 29 . . . cord-015021-pol2qm74 4523 1 We -PRON- PRP cord-015021-pol2qm74 4523 2 conclude conclude VBP cord-015021-pol2qm74 4523 3 that that IN cord-015021-pol2qm74 4523 4 thoracoscopic thoracoscopic NNP cord-015021-pol2qm74 4523 5 procedures procedure NNS cord-015021-pol2qm74 4523 6 are be VBP cord-015021-pol2qm74 4523 7 superior superior JJ cord-015021-pol2qm74 4523 8 in in IN cord-015021-pol2qm74 4523 9 reducing reduce VBG cord-015021-pol2qm74 4523 10 the the DT cord-015021-pol2qm74 4523 11 resection resection NN cord-015021-pol2qm74 4523 12 trauma trauma NN cord-015021-pol2qm74 4523 13 per per IN cord-015021-pol2qm74 4523 14 se se FW cord-015021-pol2qm74 4523 15 and and CC cord-015021-pol2qm74 4523 16 hence hence RB cord-015021-pol2qm74 4523 17 might may MD cord-015021-pol2qm74 4523 18 prevent prevent VB cord-015021-pol2qm74 4523 19 severe severe JJ cord-015021-pol2qm74 4523 20 mediamr mediamr NN cord-015021-pol2qm74 4523 21 - - HYPH cord-015021-pol2qm74 4523 22 induced induce VBN cord-015021-pol2qm74 4523 23 ( ( -LRB- cord-015021-pol2qm74 4523 24 pulmonary pulmonary JJ cord-015021-pol2qm74 4523 25 / / SYM cord-015021-pol2qm74 4523 26 systemic systemic JJ cord-015021-pol2qm74 4523 27 ) ) -RRB- cord-015021-pol2qm74 4523 28 sequelae sequela NNS cord-015021-pol2qm74 4523 29 . . . cord-015021-pol2qm74 4524 1 In in IN cord-015021-pol2qm74 4524 2 a a DT cord-015021-pol2qm74 4524 3 prospective prospective JJ cord-015021-pol2qm74 4524 4 study study NN cord-015021-pol2qm74 4524 5 we -PRON- PRP cord-015021-pol2qm74 4524 6 investigated investigate VBD cord-015021-pol2qm74 4524 7 45 45 CD cord-015021-pol2qm74 4524 8 patients patient NNS cord-015021-pol2qm74 4524 9 using use VBG cord-015021-pol2qm74 4524 10 radiochemical radiochemical JJ cord-015021-pol2qm74 4524 11 method method NN cord-015021-pol2qm74 4524 12 according accord VBG cord-015021-pol2qm74 4524 13 to to IN cord-015021-pol2qm74 4524 14 Sch Sch NNP cord-015021-pol2qm74 4524 15 ~ ~ NNP cord-015021-pol2qm74 4524 16 dlich dlich NNP cord-015021-pol2qm74 4524 17 ( ( -LRB- cord-015021-pol2qm74 4524 18 S S NNP cord-015021-pol2qm74 4524 19 ) ) -RRB- cord-015021-pol2qm74 4524 20 and and CC cord-015021-pol2qm74 4524 21 photometric photometric JJ cord-015021-pol2qm74 4524 22 method method NN cord-015021-pol2qm74 4524 23 according accord VBG cord-015021-pol2qm74 4524 24 to to IN cord-015021-pol2qm74 4524 25 Hoffmann Hoffmann NNP cord-015021-pol2qm74 4524 26 ( ( -LRB- cord-015021-pol2qm74 4524 27 H H NNP cord-015021-pol2qm74 4524 28 ) ) -RRB- cord-015021-pol2qm74 4524 29 . . . cord-015021-pol2qm74 4525 1 Serum serum NN cord-015021-pol2qm74 4525 2 of of IN cord-015021-pol2qm74 4525 3 severly severly RB cord-015021-pol2qm74 4525 4 traumatized traumatize VBN cord-015021-pol2qm74 4525 5 patients patient NNS cord-015021-pol2qm74 4525 6 was be VBD cord-015021-pol2qm74 4525 7 withdrawn withdraw VBN cord-015021-pol2qm74 4525 8 directly directly RB cord-015021-pol2qm74 4525 9 after after IN cord-015021-pol2qm74 4525 10 admission admission NN cord-015021-pol2qm74 4525 11 at at IN cord-015021-pol2qm74 4525 12 our -PRON- PRP$ cord-015021-pol2qm74 4525 13 emergency emergency NN cord-015021-pol2qm74 4525 14 room room NN cord-015021-pol2qm74 4525 15 and and CC cord-015021-pol2qm74 4525 16 in in IN cord-015021-pol2qm74 4525 17 narrow narrow JJ cord-015021-pol2qm74 4525 18 time time NN cord-015021-pol2qm74 4525 19 intervals interval NNS cord-015021-pol2qm74 4525 20 during during IN cord-015021-pol2qm74 4525 21 first first JJ cord-015021-pol2qm74 4525 22 24 24 CD cord-015021-pol2qm74 4525 23 hours hour NNS cord-015021-pol2qm74 4525 24 after after IN cord-015021-pol2qm74 4525 25 trauma trauma NN cord-015021-pol2qm74 4525 26 . . . cord-015021-pol2qm74 4526 1 Follow follow VB cord-015021-pol2qm74 4526 2 up up RP cord-015021-pol2qm74 4527 1 control control NN cord-015021-pol2qm74 4527 2 samples sample NNS cord-015021-pol2qm74 4527 3 were be VBD cord-015021-pol2qm74 4527 4 taken take VBN cord-015021-pol2qm74 4527 5 daily daily RB cord-015021-pol2qm74 4527 6 until until IN cord-015021-pol2qm74 4527 7 day day NN cord-015021-pol2qm74 4527 8 ten ten CD cord-015021-pol2qm74 4527 9 . . . cord-015021-pol2qm74 4528 1 Whereas whereas IN cord-015021-pol2qm74 4528 2 no no DT cord-015021-pol2qm74 4528 3 elevated elevated JJ cord-015021-pol2qm74 4528 4 PLA pla NN cord-015021-pol2qm74 4528 5 - - HYPH cord-015021-pol2qm74 4528 6 CA CA NNP cord-015021-pol2qm74 4528 7 was be VBD cord-015021-pol2qm74 4528 8 found find VBN cord-015021-pol2qm74 4528 9 during during IN cord-015021-pol2qm74 4528 10 first first JJ cord-015021-pol2qm74 4528 11 24 24 CD cord-015021-pol2qm74 4528 12 hours hour NNS cord-015021-pol2qm74 4528 13 , , , cord-015021-pol2qm74 4528 14 a a DT cord-015021-pol2qm74 4528 15 peak peak NN cord-015021-pol2qm74 4528 16 was be VBD cord-015021-pol2qm74 4528 17 regularly regularly RB cord-015021-pol2qm74 4528 18 observed observe VBN cord-015021-pol2qm74 4528 19 around around IN cord-015021-pol2qm74 4528 20 day day NN cord-015021-pol2qm74 4528 21 four four CD cord-015021-pol2qm74 4528 22 . . . cord-015021-pol2qm74 4529 1 There there EX cord-015021-pol2qm74 4529 2 was be VBD cord-015021-pol2qm74 4529 3 high high JJ cord-015021-pol2qm74 4529 4 correlation correlation NN cord-015021-pol2qm74 4529 5 between between IN cord-015021-pol2qm74 4529 6 PLA PLA NNP cord-015021-pol2qm74 4529 7 - - HYPH cord-015021-pol2qm74 4529 8 CA CA NNP cord-015021-pol2qm74 4529 9 and and CC cord-015021-pol2qm74 4529 10 ISS ISS NNP cord-015021-pol2qm74 4529 11 ( ( -LRB- cord-015021-pol2qm74 4529 12 r=0.71 r=0.71 NNP cord-015021-pol2qm74 4529 13 , , , cord-015021-pol2qm74 4530 1 p p NN cord-015021-pol2qm74 4530 2 < < XX cord-015021-pol2qm74 4530 3 O.O001 o.o001 XX cord-015021-pol2qm74 4530 4 ) ) -RRB- cord-015021-pol2qm74 4530 5 except except IN cord-015021-pol2qm74 4530 6 patients patient NNS cord-015021-pol2qm74 4530 7 suffering suffer VBG cord-015021-pol2qm74 4530 8 from from IN cord-015021-pol2qm74 4530 9 thoracic thoracic JJ cord-015021-pol2qm74 4530 10 trauma trauma NN cord-015021-pol2qm74 4530 11 , , , cord-015021-pol2qm74 4530 12 Thoracic thoracic JJ cord-015021-pol2qm74 4530 13 trauma trauma NN cord-015021-pol2qm74 4530 14 { { -LRB- cord-015021-pol2qm74 4530 15 TT TT NNP cord-015021-pol2qm74 4530 16 ) ) -RRB- cord-015021-pol2qm74 4530 17 provoked provoke VBD cord-015021-pol2qm74 4530 18 similar similar JJ cord-015021-pol2qm74 4530 19 gons gon NNS cord-015021-pol2qm74 4530 20 - - HYPH cord-015021-pol2qm74 4530 21 score score NN cord-015021-pol2qm74 4530 22 - - HYPH cord-015021-pol2qm74 4530 23 and and CC cord-015021-pol2qm74 4530 24 PLA PLA NNP cord-015021-pol2qm74 4530 25 - - HYPH cord-015021-pol2qm74 4530 26 CA ca NN cord-015021-pol2qm74 4530 27 - - HYPH cord-015021-pol2qm74 4530 28 values value NNS cord-015021-pol2qm74 4530 29 compared compare VBN cord-015021-pol2qm74 4530 30 to to IN cord-015021-pol2qm74 4530 31 multiple multiple JJ cord-015021-pol2qm74 4530 32 trauma trauma NN cord-015021-pol2qm74 4530 33 ( ( -LRB- cord-015021-pol2qm74 4530 34 MT MT NNP cord-015021-pol2qm74 4530 35 ) ) -RRB- cord-015021-pol2qm74 4530 36 despite despite IN cord-015021-pol2qm74 4530 37 significantly significantly RB cord-015021-pol2qm74 4530 38 lower low JJR cord-015021-pol2qm74 4530 39 ISS ISS NNP cord-015021-pol2qm74 4530 40 : : : cord-015021-pol2qm74 4530 41 PLA PLA NNP cord-015021-pol2qm74 4530 42 - - HYPH cord-015021-pol2qm74 4530 43 CA CA NNP cord-015021-pol2qm74 4530 44 ( ( -LRB- cord-015021-pol2qm74 4530 45 H H NNP cord-015021-pol2qm74 4530 46 ) ) -RRB- cord-015021-pol2qm74 4530 47 MT MT NNP cord-015021-pol2qm74 4530 48 32.9 32.9 CD cord-015021-pol2qm74 4530 49 + + SYM cord-015021-pol2qm74 4530 50 6.4 6.4 CD cord-015021-pol2qm74 4530 51 TT TT NNP cord-015021-pol2qm74 4530 52 28,7 28,7 CD cord-015021-pol2qm74 4531 1 + + CC cord-015021-pol2qm74 4531 2 _ _ NN cord-015021-pol2qm74 4531 3 9,5 9,5 NNP cord-015021-pol2qm74 4531 4 n.s n.s NNP cord-015021-pol2qm74 4531 5 . . . cord-015021-pol2qm74 4531 6 PLA PLA NNP cord-015021-pol2qm74 4531 7 - - HYPH cord-015021-pol2qm74 4531 8 CA(S ca(s JJ cord-015021-pol2qm74 4531 9 ) ) -RRB- cord-015021-pol2qm74 4531 10 MT MT NNP cord-015021-pol2qm74 4531 11 11.7 11.7 CD cord-015021-pol2qm74 4532 1 + + CC cord-015021-pol2qm74 4532 2 _ _ NN cord-015021-pol2qm74 4533 1 2.6 2.6 CD cord-015021-pol2qm74 4533 2 TT8.3 TT8.3 NNP cord-015021-pol2qm74 4533 3 _ _ NNP cord-015021-pol2qm74 4533 4 + + SYM cord-015021-pol2qm74 4533 5 2.6 2.6 CD cord-015021-pol2qm74 4533 6 n.s n.s NN cord-015021-pol2qm74 4533 7 . . . cord-015021-pol2qm74 4533 8 Goris Goris NNP cord-015021-pol2qm74 4533 9 MT MT NNP cord-015021-pol2qm74 4533 10 3.5 3.5 CD cord-015021-pol2qm74 4533 11 4 4 CD cord-015021-pol2qm74 4533 12 - - SYM cord-015021-pol2qm74 4533 13 0.7 0.7 CD cord-015021-pol2qm74 4534 1 TT3.6 TT3.6 NNP cord-015021-pol2qm74 4534 2 _ _ NNP cord-015021-pol2qm74 4534 3 + + CC cord-015021-pol2qm74 4534 4 1.3 1.3 CD cord-015021-pol2qm74 4534 5 n.s n.s NNP cord-015021-pol2qm74 4534 6 . . NNP cord-015021-pol2qm74 4534 7 ISS ISS NNP cord-015021-pol2qm74 4534 8 MT MT NNP cord-015021-pol2qm74 4534 9 35 35 CD cord-015021-pol2qm74 4534 10 4 4 CD cord-015021-pol2qm74 4534 11 - - SYM cord-015021-pol2qm74 4534 12 3 3 CD cord-015021-pol2qm74 4534 13 TT21 TT21 NNP cord-015021-pol2qm74 4534 14 4 4 CD cord-015021-pol2qm74 4534 15 - - SYM cord-015021-pol2qm74 4534 16 3 3 CD cord-015021-pol2qm74 4534 17 p<0.01 p<0.01 NN cord-015021-pol2qm74 4535 1 We -PRON- PRP cord-015021-pol2qm74 4535 2 found find VBD cord-015021-pol2qm74 4535 3 delayed delayed JJ cord-015021-pol2qm74 4535 4 elevation elevation NN cord-015021-pol2qm74 4535 5 of of IN cord-015021-pol2qm74 4535 6 PLA PLA NNP cord-015021-pol2qm74 4535 7 - - HYPH cord-015021-pol2qm74 4535 8 CA CA NNP cord-015021-pol2qm74 4535 9 after after IN cord-015021-pol2qm74 4535 10 severe severe JJ cord-015021-pol2qm74 4535 11 trauma trauma NN cord-015021-pol2qm74 4535 12 , , , cord-015021-pol2qm74 4536 1 However however RB cord-015021-pol2qm74 4536 2 detection detection NN cord-015021-pol2qm74 4536 3 of of IN cord-015021-pol2qm74 4536 4 delayed delay VBN cord-015021-pol2qm74 4536 5 PLA PLA NNP cord-015021-pol2qm74 4536 6 - - HYPH cord-015021-pol2qm74 4536 7 CA CA NNP cord-015021-pol2qm74 4536 8 in in IN cord-015021-pol2qm74 4536 9 the the DT cord-015021-pol2qm74 4536 10 serum serum NN cord-015021-pol2qm74 4536 11 of of IN cord-015021-pol2qm74 4536 12 traumatized traumatize VBN cord-015021-pol2qm74 4536 13 patients patient NNS cord-015021-pol2qm74 4536 14 can can MD cord-015021-pol2qm74 4536 15 not not RB cord-015021-pol2qm74 4536 16 give give VB cord-015021-pol2qm74 4536 17 reliable reliable JJ cord-015021-pol2qm74 4536 18 information information NN cord-015021-pol2qm74 4536 19 about about IN cord-015021-pol2qm74 4536 20 the the DT cord-015021-pol2qm74 4536 21 exact exact JJ cord-015021-pol2qm74 4536 22 role role NN cord-015021-pol2qm74 4536 23 of of IN cord-015021-pol2qm74 4536 24 PLA PLA NNP cord-015021-pol2qm74 4536 25 in in IN cord-015021-pol2qm74 4536 26 the the DT cord-015021-pol2qm74 4536 27 inflammatory inflammatory JJ cord-015021-pol2qm74 4536 28 reaction reaction NN cord-015021-pol2qm74 4536 29 after after IN cord-015021-pol2qm74 4536 30 trauma trauma NN cord-015021-pol2qm74 4536 31 as as IN cord-015021-pol2qm74 4536 32 latest late JJS cord-015021-pol2qm74 4536 33 results result NNS cord-015021-pol2qm74 4536 34 show show VBP cord-015021-pol2qm74 4536 35 that that IN cord-015021-pol2qm74 4536 36 PLA PLA NNP cord-015021-pol2qm74 4536 37 is be VBZ cord-015021-pol2qm74 4536 38 secreted secrete VBN cord-015021-pol2qm74 4536 39 early early RB cord-015021-pol2qm74 4536 40 but but CC cord-015021-pol2qm74 4536 41 bound bind VBN cord-015021-pol2qm74 4536 42 at at IN cord-015021-pol2qm74 4536 43 lipophilic lipophilic JJ cord-015021-pol2qm74 4536 44 sites site NNS cord-015021-pol2qm74 4536 45 of of IN cord-015021-pol2qm74 4536 46 vascular vascular JJ cord-015021-pol2qm74 4536 47 membranes membrane NNS cord-015021-pol2qm74 4536 48 . . . cord-015021-pol2qm74 4537 1 Hern Hern NNP cord-015021-pol2qm74 4537 2 ~ ~ NFP cord-015021-pol2qm74 4537 3 mdez mdez NNP cord-015021-pol2qm74 4537 4 M M NNP cord-015021-pol2qm74 4537 5 J J NNP cord-015021-pol2qm74 4537 6 , , , cord-015021-pol2qm74 4537 7 Amiguet Amiguet NNP cord-015021-pol2qm74 4537 8 JA JA NNP cord-015021-pol2qm74 4537 9 , , , cord-015021-pol2qm74 4537 10 Monreal Monreal NNP cord-015021-pol2qm74 4537 11 JI JI NNP cord-015021-pol2qm74 4537 12 , , , cord-015021-pol2qm74 4537 13 Vid vid NN cord-015021-pol2qm74 4537 14 ~ ~ NFP cord-015021-pol2qm74 4537 15 n n NNP cord-015021-pol2qm74 4537 16 JR JR NNP cord-015021-pol2qm74 4537 17 , , , cord-015021-pol2qm74 4537 18 Jim6nez Jim6nez NNP cord-015021-pol2qm74 4537 19 F F NNP cord-015021-pol2qm74 4537 20 J J NNP cord-015021-pol2qm74 4537 21 , , , cord-015021-pol2qm74 4537 22 L6pez L6pez NNP cord-015021-pol2qm74 4537 23 - - HYPH cord-015021-pol2qm74 4537 24 Vivanco Vivanco NNP cord-015021-pol2qm74 4537 25 G G NNP cord-015021-pol2qm74 4537 26 Acute acute NN cord-015021-pol2qm74 4537 27 phase phase NN cord-015021-pol2qm74 4537 28 reactant reactant NN cord-015021-pol2qm74 4537 29 proteins protein NNS cord-015021-pol2qm74 4537 30 increment increment NN cord-015021-pol2qm74 4537 31 in in IN cord-015021-pol2qm74 4537 32 serum serum NN cord-015021-pol2qm74 4537 33 of of IN cord-015021-pol2qm74 4537 34 patients patient NNS cord-015021-pol2qm74 4537 35 with with IN cord-015021-pol2qm74 4537 36 traumatisms traumatism NNS cord-015021-pol2qm74 4537 37 and and CC cord-015021-pol2qm74 4537 38 inflammation inflammation NN cord-015021-pol2qm74 4537 39 has have VBZ cord-015021-pol2qm74 4537 40 been be VBN cord-015021-pol2qm74 4537 41 previously previously RB cord-015021-pol2qm74 4537 42 reported report VBN cord-015021-pol2qm74 4537 43 . . . cord-015021-pol2qm74 4538 1 Alpha-1 alpha-1 JJ cord-015021-pol2qm74 4538 2 antitrypsin antitrypsin NN cord-015021-pol2qm74 4538 3 ( ( -LRB- cord-015021-pol2qm74 4538 4 AAT AAT NNP cord-015021-pol2qm74 4538 5 ) ) -RRB- cord-015021-pol2qm74 4538 6 , , . cord-015021-pol2qm74 4539 1 Alpha-2 Alpha-2 NNP cord-015021-pol2qm74 4539 2 macroglobulin macroglobulin NNP cord-015021-pol2qm74 4539 3 ( ( -LRB- cord-015021-pol2qm74 4539 4 AMG AMG NNP cord-015021-pol2qm74 4539 5 ) ) -RRB- cord-015021-pol2qm74 4539 6 and and CC cord-015021-pol2qm74 4539 7 Ceruloplasmin Ceruloplasmin NNP cord-015021-pol2qm74 4539 8 ( ( -LRB- cord-015021-pol2qm74 4539 9 Cp Cp NNP cord-015021-pol2qm74 4539 10 ) ) -RRB- cord-015021-pol2qm74 4539 11 are be VBP cord-015021-pol2qm74 4539 12 evaluated evaluate VBN cord-015021-pol2qm74 4539 13 in in IN cord-015021-pol2qm74 4539 14 the the DT cord-015021-pol2qm74 4539 15 following following NN cord-015021-pol2qm74 4539 16 of of IN cord-015021-pol2qm74 4539 17 33 33 CD cord-015021-pol2qm74 4539 18 patients patient NNS cord-015021-pol2qm74 4539 19 , , , cord-015021-pol2qm74 4539 20 27 27 CD cord-015021-pol2qm74 4539 21 males male NNS cord-015021-pol2qm74 4539 22 and and CC cord-015021-pol2qm74 4539 23 6 6 CD cord-015021-pol2qm74 4539 24 females female NNS cord-015021-pol2qm74 4539 25 ( ( -LRB- cord-015021-pol2qm74 4539 26 mean mean VB cord-015021-pol2qm74 4539 27 age age NN cord-015021-pol2qm74 4539 28 : : : cord-015021-pol2qm74 4539 29 43 43 CD cord-015021-pol2qm74 4539 30 years year NNS cord-015021-pol2qm74 4539 31 ) ) -RRB- cord-015021-pol2qm74 4539 32 , , , cord-015021-pol2qm74 4539 33 with with IN cord-015021-pol2qm74 4539 34 compound compound NN cord-015021-pol2qm74 4539 35 fractures fracture NNS cord-015021-pol2qm74 4539 36 . . . cord-015021-pol2qm74 4540 1 57 57 CD cord-015021-pol2qm74 4540 2 % % NN cord-015021-pol2qm74 4540 3 of of IN cord-015021-pol2qm74 4540 4 them -PRON- PRP cord-015021-pol2qm74 4540 5 were be VBD cord-015021-pol2qm74 4540 6 located locate VBN cord-015021-pol2qm74 4540 7 in in IN cord-015021-pol2qm74 4540 8 tibia tibia NN cord-015021-pol2qm74 4540 9 and and CC cord-015021-pol2qm74 4540 10 fibula fibula NN cord-015021-pol2qm74 4540 11 . . . cord-015021-pol2qm74 4541 1 Intercurrent intercurrent NN cord-015021-pol2qm74 4541 2 infection infection NN cord-015021-pol2qm74 4541 3 developed develop VBD cord-015021-pol2qm74 4541 4 in in IN cord-015021-pol2qm74 4541 5 4 4 CD cord-015021-pol2qm74 4541 6 patients patient NNS cord-015021-pol2qm74 4541 7 and and CC cord-015021-pol2qm74 4541 8 internal internal JJ cord-015021-pol2qm74 4541 9 fixation fixation NN cord-015021-pol2qm74 4541 10 rejection rejection NN cord-015021-pol2qm74 4541 11 in in IN cord-015021-pol2qm74 4541 12 one one CD cord-015021-pol2qm74 4541 13 . . . cord-015021-pol2qm74 4542 1 Measurements measurement NNS cord-015021-pol2qm74 4542 2 were be VBD cord-015021-pol2qm74 4542 3 made make VBN cord-015021-pol2qm74 4542 4 by by IN cord-015021-pol2qm74 4542 5 radial radial JJ cord-015021-pol2qm74 4542 6 immunodiffusion immunodiffusion NN cord-015021-pol2qm74 4542 7 on on IN cord-015021-pol2qm74 4542 8 days day NNS cord-015021-pol2qm74 4542 9 0 0 CD cord-015021-pol2qm74 4542 10 , , , cord-015021-pol2qm74 4542 11 3 3 CD cord-015021-pol2qm74 4542 12 , , , cord-015021-pol2qm74 4542 13 10 10 CD cord-015021-pol2qm74 4542 14 , , , cord-015021-pol2qm74 4542 15 17 17 CD cord-015021-pol2qm74 4542 16 , , , cord-015021-pol2qm74 4542 17 24 24 CD cord-015021-pol2qm74 4542 18 , , , cord-015021-pol2qm74 4542 19 31 31 CD cord-015021-pol2qm74 4542 20 and and CC cord-015021-pol2qm74 4542 21 38 38 CD cord-015021-pol2qm74 4542 22 . . . cord-015021-pol2qm74 4543 1 A a DT cord-015021-pol2qm74 4543 2 control control NN cord-015021-pol2qm74 4543 3 group group NN cord-015021-pol2qm74 4543 4 of of IN cord-015021-pol2qm74 4543 5 30 30 CD cord-015021-pol2qm74 4543 6 healthy healthy JJ cord-015021-pol2qm74 4543 7 volunteers volunteer NNS cord-015021-pol2qm74 4543 8 was be VBD cord-015021-pol2qm74 4543 9 also also RB cord-015021-pol2qm74 4543 10 evaluated evaluate VBN cord-015021-pol2qm74 4543 11 . . . cord-015021-pol2qm74 4544 1 AAT AAT NNP cord-015021-pol2qm74 4544 2 and and CC cord-015021-pol2qm74 4544 3 Cp Cp NNP cord-015021-pol2qm74 4544 4 showed show VBD cord-015021-pol2qm74 4544 5 increased increase VBN cord-015021-pol2qm74 4544 6 values value NNS cord-015021-pol2qm74 4544 7 from from IN cord-015021-pol2qm74 4544 8 day day NN cord-015021-pol2qm74 4544 9 3 3 CD cord-015021-pol2qm74 4544 10 which which WDT cord-015021-pol2qm74 4544 11 kept keep VBD cord-015021-pol2qm74 4544 12 elevated elevate VBN cord-015021-pol2qm74 4544 13 untill untill IN cord-015021-pol2qm74 4544 14 the the DT cord-015021-pol2qm74 4544 15 end end NN cord-015021-pol2qm74 4544 16 of of IN cord-015021-pol2qm74 4544 17 the the DT cord-015021-pol2qm74 4544 18 study study NN cord-015021-pol2qm74 4544 19 . . . cord-015021-pol2qm74 4545 1 AMG AMG NNP cord-015021-pol2qm74 4545 2 elevated elevate VBD cord-015021-pol2qm74 4545 3 from from IN cord-015021-pol2qm74 4545 4 day day NN cord-015021-pol2qm74 4545 5 24 24 CD cord-015021-pol2qm74 4545 6 . . . cord-015021-pol2qm74 4546 1 When when WRB cord-015021-pol2qm74 4546 2 infection infection NN cord-015021-pol2qm74 4546 3 developed develop VBD cord-015021-pol2qm74 4546 4 , , , cord-015021-pol2qm74 4546 5 AAT AAT NNP cord-015021-pol2qm74 4546 6 and and CC cord-015021-pol2qm74 4546 7 Cp Cp NNP cord-015021-pol2qm74 4546 8 values value NNS cord-015021-pol2qm74 4546 9 were be VBD cord-015021-pol2qm74 4546 10 even even RB cord-015021-pol2qm74 4546 11 higher high JJR cord-015021-pol2qm74 4546 12 whereas whereas IN cord-015021-pol2qm74 4546 13 AMG AMG NNP cord-015021-pol2qm74 4546 14 values value NNS cord-015021-pol2qm74 4546 15 decreased decrease VBD cord-015021-pol2qm74 4546 16 . . . cord-015021-pol2qm74 4547 1 Fixation fixation NN cord-015021-pol2qm74 4547 2 rejection rejection NN cord-015021-pol2qm74 4547 3 caused cause VBD cord-015021-pol2qm74 4547 4 AAT AAT NNP cord-015021-pol2qm74 4547 5 , , , cord-015021-pol2qm74 4547 6 AMG AMG NNP cord-015021-pol2qm74 4547 7 and and CC cord-015021-pol2qm74 4547 8 Cp Cp NNP cord-015021-pol2qm74 4547 9 increment increment NN cord-015021-pol2qm74 4547 10 . . . cord-015021-pol2qm74 4548 1 AAT AAT NNP cord-015021-pol2qm74 4548 2 and and CC cord-015021-pol2qm74 4548 3 Cp Cp NNP cord-015021-pol2qm74 4548 4 increment increment VB cord-015021-pol2qm74 4548 5 in in IN cord-015021-pol2qm74 4548 6 non non JJ cord-015021-pol2qm74 4548 7 complicated complicated JJ cord-015021-pol2qm74 4548 8 fractures fracture NNS cord-015021-pol2qm74 4548 9 might may MD cord-015021-pol2qm74 4548 10 be be VB cord-015021-pol2qm74 4548 11 due due JJ cord-015021-pol2qm74 4548 12 to to IN cord-015021-pol2qm74 4548 13 accompanying accompany VBG cord-015021-pol2qm74 4548 14 inflamation inflamation NN cord-015021-pol2qm74 4548 15 , , , cord-015021-pol2qm74 4548 16 by by IN cord-015021-pol2qm74 4548 17 means mean NNS cord-015021-pol2qm74 4548 18 of of IN cord-015021-pol2qm74 4548 19 cytokines cytokine NNS cord-015021-pol2qm74 4548 20 release release NN cord-015021-pol2qm74 4548 21 and and CC cord-015021-pol2qm74 4548 22 APRPs APRPs NNPS cord-015021-pol2qm74 4548 23 hepatic hepatic JJ cord-015021-pol2qm74 4548 24 synthesis synthesis NN cord-015021-pol2qm74 4548 25 induction induction NN cord-015021-pol2qm74 4548 26 . . . cord-015021-pol2qm74 4549 1 Therefore therefore RB cord-015021-pol2qm74 4549 2 , , , cord-015021-pol2qm74 4549 3 increment increment NN cord-015021-pol2qm74 4549 4 is be VBZ cord-015021-pol2qm74 4549 5 higher high JJR cord-015021-pol2qm74 4549 6 when when WRB cord-015021-pol2qm74 4549 7 infection infection NN cord-015021-pol2qm74 4549 8 or or CC cord-015021-pol2qm74 4549 9 rejection rejection NN cord-015021-pol2qm74 4549 10 develop develop VB cord-015021-pol2qm74 4549 11 . . . cord-015021-pol2qm74 4550 1 AMG AMG NNP cord-015021-pol2qm74 4550 2 behaviour behaviour NN cord-015021-pol2qm74 4550 3 at at IN cord-015021-pol2qm74 4550 4 early early JJ cord-015021-pol2qm74 4550 5 stages stage NNS cord-015021-pol2qm74 4550 6 of of IN cord-015021-pol2qm74 4550 7 evolution evolution NN cord-015021-pol2qm74 4550 8 is be VBZ cord-015021-pol2qm74 4550 9 secondary secondary JJ cord-015021-pol2qm74 4550 10 to to IN cord-015021-pol2qm74 4550 11 hiperconsumption hiperconsumption NN cord-015021-pol2qm74 4550 12 , , , cord-015021-pol2qm74 4550 13 considering consider VBG cord-015021-pol2qm74 4550 14 mean mean VB cord-015021-pol2qm74 4550 15 life life NN cord-015021-pol2qm74 4550 16 shortening shorten VBG cord-015021-pol2qm74 4550 17 after after IN cord-015021-pol2qm74 4550 18 proteases protease NNS cord-015021-pol2qm74 4550 19 ligation ligation NN cord-015021-pol2qm74 4550 20 . . . cord-015021-pol2qm74 4551 1 AMG AMG NNP cord-015021-pol2qm74 4551 2 modifications modification NNS cord-015021-pol2qm74 4551 3 in in IN cord-015021-pol2qm74 4551 4 fixation fixation NN cord-015021-pol2qm74 4551 5 rejection rejection NN cord-015021-pol2qm74 4551 6 remain remain VBP cord-015021-pol2qm74 4551 7 obscure obscure JJ cord-015021-pol2qm74 4551 8 . . . cord-015021-pol2qm74 4552 1 APRPs aprps NN cord-015021-pol2qm74 4552 2 increment increment NN cord-015021-pol2qm74 4552 3 modulates modulate VBZ cord-015021-pol2qm74 4552 4 inflammation inflammation NN cord-015021-pol2qm74 4552 5 and and CC cord-015021-pol2qm74 4552 6 bony bony JJ cord-015021-pol2qm74 4552 7 callus callus NN cord-015021-pol2qm74 4552 8 formation formation NN cord-015021-pol2qm74 4552 9 by by IN cord-015021-pol2qm74 4552 10 means mean VBZ cord-015021-pol2qm74 4552 11 their -PRON- PRP$ cord-015021-pol2qm74 4552 12 antyprotease antyprotease NN cord-015021-pol2qm74 4552 13 and and CC cord-015021-pol2qm74 4552 14 antioxidant antioxidant JJ cord-015021-pol2qm74 4552 15 properties property NNS cord-015021-pol2qm74 4552 16 . . . cord-015021-pol2qm74 4553 1 Clinically clinically RB cord-015021-pol2qm74 4553 2 , , , cord-015021-pol2qm74 4553 3 APRPs APRPs NNP cord-015021-pol2qm74 4553 4 might may MD cord-015021-pol2qm74 4553 5 be be VB cord-015021-pol2qm74 4553 6 useful useful JJ cord-015021-pol2qm74 4553 7 parameters parameter NNS cord-015021-pol2qm74 4553 8 in in IN cord-015021-pol2qm74 4553 9 determining determine VBG cord-015021-pol2qm74 4553 10 complications complication NNS cord-015021-pol2qm74 4553 11 onset onset NN cord-015021-pol2qm74 4553 12 in in IN cord-015021-pol2qm74 4553 13 fractures fracture NNS cord-015021-pol2qm74 4553 14 evolution evolution NN cord-015021-pol2qm74 4553 15 . . . cord-015021-pol2qm74 4554 1 Hemorrhagic hemorrhagic JJ cord-015021-pol2qm74 4554 2 shock shock NN cord-015021-pol2qm74 4554 3 ( ( -LRB- cord-015021-pol2qm74 4554 4 HS HS NNP cord-015021-pol2qm74 4554 5 ) ) -RRB- cord-015021-pol2qm74 4554 6 is be VBZ cord-015021-pol2qm74 4554 7 a a DT cord-015021-pol2qm74 4554 8 common common JJ cord-015021-pol2qm74 4554 9 complication complication NN cord-015021-pol2qm74 4554 10 of of IN cord-015021-pol2qm74 4554 11 trauma trauma NN cord-015021-pol2qm74 4554 12 , , , cord-015021-pol2qm74 4554 13 as as RB cord-015021-pol2qm74 4554 14 well well RB cord-015021-pol2qm74 4554 15 as as IN cord-015021-pol2qm74 4554 16 some some DT cord-015021-pol2qm74 4554 17 major major JJ cord-015021-pol2qm74 4554 18 surgical surgical JJ cord-015021-pol2qm74 4554 19 procedures procedure NNS cord-015021-pol2qm74 4554 20 . . . cord-015021-pol2qm74 4555 1 The the DT cord-015021-pol2qm74 4555 2 alteration alteration NN cord-015021-pol2qm74 4555 3 of of IN cord-015021-pol2qm74 4555 4 the the DT cord-015021-pol2qm74 4555 5 immune immune JJ cord-015021-pol2qm74 4555 6 system system NN cord-015021-pol2qm74 4555 7 by by IN cord-015021-pol2qm74 4555 8 HS HS NNP cord-015021-pol2qm74 4555 9 is be VBZ cord-015021-pol2qm74 4555 10 thought think VBN cord-015021-pol2qm74 4555 11 to to TO cord-015021-pol2qm74 4555 12 contribute contribute VB cord-015021-pol2qm74 4555 13 to to IN cord-015021-pol2qm74 4555 14 the the DT cord-015021-pol2qm74 4555 15 increased increase VBN cord-015021-pol2qm74 4555 16 septic septic JJ cord-015021-pol2qm74 4555 17 morbidity morbidity NN cord-015021-pol2qm74 4555 18 and and CC cord-015021-pol2qm74 4555 19 mortality mortality NN cord-015021-pol2qm74 4555 20 seen see VBN cord-015021-pol2qm74 4555 21 in in IN cord-015021-pol2qm74 4555 22 these these DT cord-015021-pol2qm74 4555 23 patients patient NNS cord-015021-pol2qm74 4555 24 . . . cord-015021-pol2qm74 4556 1 Multiple multiple JJ cord-015021-pol2qm74 4556 2 mediators mediator NNS cord-015021-pol2qm74 4556 3 are be VBP cord-015021-pol2qm74 4556 4 released release VBN cord-015021-pol2qm74 4556 5 following follow VBG cord-015021-pol2qm74 4556 6 HS HS NNP cord-015021-pol2qm74 4556 7 . . . cord-015021-pol2qm74 4557 1 IL-1 IL-1 NNP cord-015021-pol2qm74 4557 2 , , , cord-015021-pol2qm74 4557 3 IL-6 IL-6 NNP cord-015021-pol2qm74 4557 4 , , , cord-015021-pol2qm74 4557 5 TNF TNF NNP cord-015021-pol2qm74 4557 6 , , , cord-015021-pol2qm74 4557 7 PGE PGE NNP cord-015021-pol2qm74 4557 8 2 2 CD cord-015021-pol2qm74 4557 9 and and CC cord-015021-pol2qm74 4557 10 TGF TGF NNP cord-015021-pol2qm74 4557 11 - - HYPH cord-015021-pol2qm74 4557 12 B b NN cord-015021-pol2qm74 4557 13 have have VBP cord-015021-pol2qm74 4557 14 all all DT cord-015021-pol2qm74 4557 15 been be VBN cord-015021-pol2qm74 4557 16 implicated implicate VBN cord-015021-pol2qm74 4557 17 in in IN cord-015021-pol2qm74 4557 18 these these DT cord-015021-pol2qm74 4557 19 immune immune JJ cord-015021-pol2qm74 4557 20 system system NN cord-015021-pol2qm74 4557 21 changes change NNS cord-015021-pol2qm74 4557 22 . . . cord-015021-pol2qm74 4558 1 In in IN cord-015021-pol2qm74 4558 2 vitro vitro FW cord-015021-pol2qm74 4558 3 , , , cord-015021-pol2qm74 4558 4 PGE PGE NNP cord-015021-pol2qm74 4558 5 2 2 CD cord-015021-pol2qm74 4558 6 causes cause VBZ cord-015021-pol2qm74 4558 7 many many JJ cord-015021-pol2qm74 4558 8 of of IN cord-015021-pol2qm74 4558 9 the the DT cord-015021-pol2qm74 4558 10 immune immune JJ cord-015021-pol2qm74 4558 11 system system NN cord-015021-pol2qm74 4558 12 changes change VBZ cord-015021-pol2qm74 4558 13 following follow VBG cord-015021-pol2qm74 4558 14 HS HS NNP cord-015021-pol2qm74 4558 15 , , , cord-015021-pol2qm74 4558 16 yet yet CC cord-015021-pol2qm74 4558 17 the the DT cord-015021-pol2qm74 4558 18 time time NN cord-015021-pol2qm74 4558 19 course course NN cord-015021-pol2qm74 4558 20 of of IN cord-015021-pol2qm74 4558 21 PGE PGE NNP cord-015021-pol2qm74 4558 22 2 2 CD cord-015021-pol2qm74 4558 23 release release NN cord-015021-pol2qm74 4558 24 has have VBZ cord-015021-pol2qm74 4558 25 not not RB cord-015021-pol2qm74 4558 26 been be VBN cord-015021-pol2qm74 4558 27 well well RB cord-015021-pol2qm74 4558 28 deliniated deliniate VBN cord-015021-pol2qm74 4558 29 . . . cord-015021-pol2qm74 4559 1 The the DT cord-015021-pol2qm74 4559 2 aim aim NN cord-015021-pol2qm74 4559 3 of of IN cord-015021-pol2qm74 4559 4 this this DT cord-015021-pol2qm74 4559 5 study study NN cord-015021-pol2qm74 4559 6 was be VBD cord-015021-pol2qm74 4559 7 to to TO cord-015021-pol2qm74 4559 8 determine determine VB cord-015021-pol2qm74 4559 9 the the DT cord-015021-pol2qm74 4559 10 time time NN cord-015021-pol2qm74 4559 11 course course NN cord-015021-pol2qm74 4559 12 of of IN cord-015021-pol2qm74 4559 13 PGE PGE NNP cord-015021-pol2qm74 4559 14 2 2 CD cord-015021-pol2qm74 4559 15 release release NN cord-015021-pol2qm74 4559 16 by by IN cord-015021-pol2qm74 4559 17 peritoneal peritoneal JJ cord-015021-pol2qm74 4559 18 and and CC cord-015021-pol2qm74 4559 19 splenic splenic JJ cord-015021-pol2qm74 4559 20 macrophages macrophage NNS cord-015021-pol2qm74 4559 21 following follow VBG cord-015021-pol2qm74 4559 22 HS HS NNP cord-015021-pol2qm74 4559 23 . . . cord-015021-pol2qm74 4560 1 C3H C3H NNP cord-015021-pol2qm74 4560 2 / / SYM cord-015021-pol2qm74 4560 3 HEN HEN NNP cord-015021-pol2qm74 4560 4 mice mouse NNS cord-015021-pol2qm74 4560 5 were be VBD cord-015021-pol2qm74 4560 6 bled bleed VBN cord-015021-pol2qm74 4560 7 to to IN cord-015021-pol2qm74 4560 8 a a DT cord-015021-pol2qm74 4560 9 mean mean JJ cord-015021-pol2qm74 4560 10 BP BP NNP cord-015021-pol2qm74 4560 11 of of IN cord-015021-pol2qm74 4560 12 35 35 CD cord-015021-pol2qm74 4560 13 + + SYM cord-015021-pol2qm74 4560 14 5 5 CD cord-015021-pol2qm74 4560 15 mm mm NN cord-015021-pol2qm74 4561 1 Hg Hg NNP cord-015021-pol2qm74 4561 2 for for IN cord-015021-pol2qm74 4561 3 60 60 CD cord-015021-pol2qm74 4561 4 minutes minute NNS cord-015021-pol2qm74 4561 5 . . . cord-015021-pol2qm74 4562 1 The the DT cord-015021-pol2qm74 4562 2 animals animal NNS cord-015021-pol2qm74 4562 3 were be VBD cord-015021-pol2qm74 4562 4 resuscitated resuscitate VBN cord-015021-pol2qm74 4562 5 with with IN cord-015021-pol2qm74 4562 6 the the DT cord-015021-pol2qm74 4562 7 shed shed JJ cord-015021-pol2qm74 4562 8 blood blood NN cord-015021-pol2qm74 4562 9 and and CC cord-015021-pol2qm74 4562 10 normal normal JJ cord-015021-pol2qm74 4562 11 saline saline NN cord-015021-pol2qm74 4562 12 . . . cord-015021-pol2qm74 4563 1 Control control NN cord-015021-pol2qm74 4563 2 animals animal NNS cord-015021-pol2qm74 4563 3 were be VBD cord-015021-pol2qm74 4563 4 cannalated cannalate VBN cord-015021-pol2qm74 4563 5 , , , cord-015021-pol2qm74 4563 6 but but CC cord-015021-pol2qm74 4563 7 blood blood NN cord-015021-pol2qm74 4563 8 was be VBD cord-015021-pol2qm74 4563 9 not not RB cord-015021-pol2qm74 4563 10 withdrawn withdraw VBN cord-015021-pol2qm74 4563 11 . . . cord-015021-pol2qm74 4564 1 The the DT cord-015021-pol2qm74 4564 2 animals animal NNS cord-015021-pol2qm74 4564 3 were be VBD cord-015021-pol2qm74 4564 4 sacrificed sacrifice VBN cord-015021-pol2qm74 4564 5 at at IN cord-015021-pol2qm74 4564 6 2 2 CD cord-015021-pol2qm74 4564 7 , , , cord-015021-pol2qm74 4564 8 12 12 CD cord-015021-pol2qm74 4564 9 , , , cord-015021-pol2qm74 4564 10 24 24 CD cord-015021-pol2qm74 4564 11 , , , cord-015021-pol2qm74 4564 12 48 48 CD cord-015021-pol2qm74 4564 13 , , , cord-015021-pol2qm74 4564 14 and and CC cord-015021-pol2qm74 4564 15 72 72 CD cord-015021-pol2qm74 4564 16 hours hour NNS cord-015021-pol2qm74 4564 17 following follow VBG cord-015021-pol2qm74 4564 18 HS HS NNP cord-015021-pol2qm74 4564 19 . . . cord-015021-pol2qm74 4565 1 Peritoneal peritoneal JJ cord-015021-pol2qm74 4565 2 and and CC cord-015021-pol2qm74 4565 3 splenic splenic JJ cord-015021-pol2qm74 4565 4 macrophages macrophage NNS cord-015021-pol2qm74 4565 5 were be VBD cord-015021-pol2qm74 4565 6 harvested harvest VBN cord-015021-pol2qm74 4565 7 from from IN cord-015021-pol2qm74 4565 8 each each DT cord-015021-pol2qm74 4565 9 animal animal NN cord-015021-pol2qm74 4565 10 and and CC cord-015021-pol2qm74 4565 11 cultured culture VBN cord-015021-pol2qm74 4565 12 with with IN cord-015021-pol2qm74 4565 13 LPS LPS NNP cord-015021-pol2qm74 4565 14 for for IN cord-015021-pol2qm74 4565 15 24 24 CD cord-015021-pol2qm74 4565 16 hours hour NNS cord-015021-pol2qm74 4565 17 . . . cord-015021-pol2qm74 4566 1 The the DT cord-015021-pol2qm74 4566 2 supernatants supernatant NNS cord-015021-pol2qm74 4566 3 were be VBD cord-015021-pol2qm74 4566 4 collected collect VBN cord-015021-pol2qm74 4566 5 and and CC cord-015021-pol2qm74 4566 6 frozen freeze VBN cord-015021-pol2qm74 4566 7 until until IN cord-015021-pol2qm74 4566 8 assayed assay VBN cord-015021-pol2qm74 4566 9 . . . cord-015021-pol2qm74 4567 1 PGE PGE NNP cord-015021-pol2qm74 4567 2 2 2 CD cord-015021-pol2qm74 4567 3 was be VBD cord-015021-pol2qm74 4567 4 assayed assay VBN cord-015021-pol2qm74 4567 5 using use VBG cord-015021-pol2qm74 4567 6 an an DT cord-015021-pol2qm74 4567 7 ELISA ELISA NNP cord-015021-pol2qm74 4567 8 ( ( -LRB- cord-015021-pol2qm74 4567 9 Cayman Cayman NNP cord-015021-pol2qm74 4567 10 Chemical Chemical NNP cord-015021-pol2qm74 4567 11 ) ) -RRB- cord-015021-pol2qm74 4567 12 . . . cord-015021-pol2qm74 4568 1 Results result NNS cord-015021-pol2qm74 4568 2 are be VBP cord-015021-pol2qm74 4568 3 shown show VBN cord-015021-pol2qm74 4568 4 below below RB cord-015021-pol2qm74 4568 5 for for IN cord-015021-pol2qm74 4568 6 the the DT cord-015021-pol2qm74 4568 7 peritoneal peritoneal JJ cord-015021-pol2qm74 4568 8 macrophages macrophage NNS cord-015021-pol2qm74 4568 9 : : : cord-015021-pol2qm74 4568 10 PGE PGE NNP cord-015021-pol2qm74 4568 11 2 2 CD cord-015021-pol2qm74 4568 12 release release NN cord-015021-pol2qm74 4568 13 by by IN cord-015021-pol2qm74 4568 14 peritoneal peritoneal JJ cord-015021-pol2qm74 4568 15 macrophages macrophage NNS cord-015021-pol2qm74 4568 16 was be VBD cord-015021-pol2qm74 4568 17 significantly significantly RB cord-015021-pol2qm74 4568 18 elevated elevate VBN cord-015021-pol2qm74 4568 19 at at IN cord-015021-pol2qm74 4568 20 24 24 CD cord-015021-pol2qm74 4568 21 , , , cord-015021-pol2qm74 4568 22 48 48 CD cord-015021-pol2qm74 4568 23 and and CC cord-015021-pol2qm74 4568 24 72 72 CD cord-015021-pol2qm74 4568 25 hours hour NNS cord-015021-pol2qm74 4568 26 over over IN cord-015021-pol2qm74 4568 27 control control NN cord-015021-pol2qm74 4568 28 . . . cord-015021-pol2qm74 4569 1 It -PRON- PRP cord-015021-pol2qm74 4569 2 was be VBD cord-015021-pol2qm74 4569 3 maximal maximal JJ cord-015021-pol2qm74 4569 4 at at IN cord-015021-pol2qm74 4569 5 48 48 CD cord-015021-pol2qm74 4569 6 hours hour NNS cord-015021-pol2qm74 4569 7 , , , cord-015021-pol2qm74 4569 8 but but CC cord-015021-pol2qm74 4569 9 by by IN cord-015021-pol2qm74 4569 10 72 72 CD cord-015021-pol2qm74 4569 11 hours hour NNS cord-015021-pol2qm74 4569 12 it -PRON- PRP cord-015021-pol2qm74 4569 13 had have VBD cord-015021-pol2qm74 4569 14 started start VBN cord-015021-pol2qm74 4569 15 to to TO cord-015021-pol2qm74 4569 16 decline decline VB cord-015021-pol2qm74 4569 17 . . . cord-015021-pol2qm74 4570 1 Splenic Splenic NNP cord-015021-pol2qm74 4570 2 macrophage macrophage NN cord-015021-pol2qm74 4570 3 PGE2 PGE2 NNP cord-015021-pol2qm74 4570 4 release release NN cord-015021-pol2qm74 4570 5 was be VBD cord-015021-pol2qm74 4570 6 much much RB cord-015021-pol2qm74 4570 7 more more RBR cord-015021-pol2qm74 4570 8 variable variable JJ cord-015021-pol2qm74 4570 9 . . . cord-015021-pol2qm74 4571 1 ( ( -LRB- cord-015021-pol2qm74 4571 2 Data datum NNS cord-015021-pol2qm74 4571 3 not not RB cord-015021-pol2qm74 4571 4 shown show VBN cord-015021-pol2qm74 4571 5 . . . cord-015021-pol2qm74 4571 6 ) ) -RRB- cord-015021-pol2qm74 4572 1 There there EX cord-015021-pol2qm74 4572 2 was be VBD cord-015021-pol2qm74 4572 3 less less JJR cord-015021-pol2qm74 4572 4 consistency consistency NN cord-015021-pol2qm74 4572 5 between between IN cord-015021-pol2qm74 4572 6 time time NN cord-015021-pol2qm74 4572 7 points point NNS cord-015021-pol2qm74 4572 8 and and CC cord-015021-pol2qm74 4572 9 no no DT cord-015021-pol2qm74 4572 10 clear clear JJ cord-015021-pol2qm74 4572 11 trend trend NN cord-015021-pol2qm74 4572 12 was be VBD cord-015021-pol2qm74 4572 13 seen see VBN cord-015021-pol2qm74 4572 14 . . . cord-015021-pol2qm74 4573 1 In in IN cord-015021-pol2qm74 4573 2 conclusion conclusion NN cord-015021-pol2qm74 4573 3 , , , cord-015021-pol2qm74 4573 4 PGE PGE NNP cord-015021-pol2qm74 4573 5 2 2 CD cord-015021-pol2qm74 4573 6 is be VBZ cord-015021-pol2qm74 4573 7 significantly significantly RB cord-015021-pol2qm74 4573 8 elevated elevate VBN cord-015021-pol2qm74 4573 9 at at IN cord-015021-pol2qm74 4573 10 24 24 CD cord-015021-pol2qm74 4573 11 hours hour NNS cord-015021-pol2qm74 4573 12 following follow VBG cord-015021-pol2qm74 4573 13 HS HS NNP cord-015021-pol2qm74 4573 14 , , , cord-015021-pol2qm74 4573 15 and and CC cord-015021-pol2qm74 4573 16 reaches reach VBZ cord-015021-pol2qm74 4573 17 a a DT cord-015021-pol2qm74 4573 18 peak peak NN cord-015021-pol2qm74 4573 19 at at IN cord-015021-pol2qm74 4573 20 48 48 CD cord-015021-pol2qm74 4573 21 hours hour NNS cord-015021-pol2qm74 4573 22 . . . cord-015021-pol2qm74 4574 1 PGE PGE NNP cord-015021-pol2qm74 4574 2 2 2 CD cord-015021-pol2qm74 4574 3 release release NN cord-015021-pol2qm74 4574 4 may may MD cord-015021-pol2qm74 4574 5 be be VB cord-015021-pol2qm74 4574 6 responsible responsible JJ cord-015021-pol2qm74 4574 7 for for IN cord-015021-pol2qm74 4574 8 the the DT cord-015021-pol2qm74 4574 9 immune immune JJ cord-015021-pol2qm74 4574 10 system system NN cord-015021-pol2qm74 4574 11 changes change NNS cord-015021-pol2qm74 4574 12 seen see VBN cord-015021-pol2qm74 4574 13 in in IN cord-015021-pol2qm74 4574 14 the the DT cord-015021-pol2qm74 4574 15 first first JJ cord-015021-pol2qm74 4574 16 few few JJ cord-015021-pol2qm74 4574 17 days day NNS cord-015021-pol2qm74 4574 18 following follow VBG cord-015021-pol2qm74 4574 19 HS HS NNP cord-015021-pol2qm74 4574 20 . . . cord-015021-pol2qm74 4575 1 Splenic splenic JJ cord-015021-pol2qm74 4575 2 and and CC cord-015021-pol2qm74 4575 3 peritoneal peritoneal JJ cord-015021-pol2qm74 4575 4 macrophages macrophage NNS cord-015021-pol2qm74 4576 1 resPOnd resPOnd NNP cord-015021-pol2qm74 4576 2 differently differently RB cord-015021-pol2qm74 4576 3 in in IN cord-015021-pol2qm74 4576 4 their -PRON- PRP$ cord-015021-pol2qm74 4576 5 release release NN cord-015021-pol2qm74 4576 6 of of IN cord-015021-pol2qm74 4576 7 PGE PGE NNP cord-015021-pol2qm74 4576 8 2 2 CD cord-015021-pol2qm74 4576 9 following follow VBG cord-015021-pol2qm74 4576 10 HS HS NNP cord-015021-pol2qm74 4576 11 ; ; : cord-015021-pol2qm74 4576 12 which which WDT cord-015021-pol2qm74 4576 13 may may MD cord-015021-pol2qm74 4576 14 be be VB cord-015021-pol2qm74 4576 15 due due JJ cord-015021-pol2qm74 4576 16 to to IN cord-015021-pol2qm74 4576 17 differences difference NNS cord-015021-pol2qm74 4576 18 in in IN cord-015021-pol2qm74 4576 19 their -PRON- PRP$ cord-015021-pol2qm74 4576 20 milieu milieu NN cord-015021-pol2qm74 4576 21 . . . cord-015021-pol2qm74 4577 1 There there EX cord-015021-pol2qm74 4577 2 is be VBZ cord-015021-pol2qm74 4577 3 an an DT cord-015021-pol2qm74 4577 4 obvious obvious JJ cord-015021-pol2qm74 4577 5 association association NN cord-015021-pol2qm74 4577 6 between between IN cord-015021-pol2qm74 4577 7 the the DT cord-015021-pol2qm74 4577 8 altered alter VBN cord-015021-pol2qm74 4577 9 immunocompetence immunocompetence NN cord-015021-pol2qm74 4577 10 of of IN cord-015021-pol2qm74 4577 11 patients patient NNS cord-015021-pol2qm74 4577 12 following follow VBG cord-015021-pol2qm74 4577 13 traumatic traumatic JJ cord-015021-pol2qm74 4577 14 injury injury NN cord-015021-pol2qm74 4577 15 of of IN cord-015021-pol2qm74 4577 16 various various JJ cord-015021-pol2qm74 4577 17 types type NNS cord-015021-pol2qm74 4577 18 and and CC cord-015021-pol2qm74 4577 19 the the DT cord-015021-pol2qm74 4577 20 increased increase VBN cord-015021-pol2qm74 4577 21 riskto riskto NN cord-015021-pol2qm74 4577 22 develop develop VBP cord-015021-pol2qm74 4577 23 complications complication NNS cord-015021-pol2qm74 4577 24 . . . cord-015021-pol2qm74 4578 1 The the DT cord-015021-pol2qm74 4578 2 present present JJ cord-015021-pol2qm74 4578 3 investigation investigation NN cord-015021-pol2qm74 4578 4 was be VBD cord-015021-pol2qm74 4578 5 undertaken undertake VBN cord-015021-pol2qm74 4578 6 in in IN cord-015021-pol2qm74 4578 7 order order NN cord-015021-pol2qm74 4578 8 to to TO cord-015021-pol2qm74 4578 9 analyze analyze VB cord-015021-pol2qm74 4578 10 the the DT cord-015021-pol2qm74 4578 11 value value NN cord-015021-pol2qm74 4578 12 of of IN cord-015021-pol2qm74 4578 13 both both CC cord-015021-pol2qm74 4578 14 Neopterin Neopterin NNP cord-015021-pol2qm74 4578 15 ( ( -LRB- cord-015021-pol2qm74 4578 16 N N NNP cord-015021-pol2qm74 4578 17 ) ) -RRB- cord-015021-pol2qm74 4578 18 and and CC cord-015021-pol2qm74 4578 19 C C NNP cord-015021-pol2qm74 4578 20 - - HYPH cord-015021-pol2qm74 4578 21 reactive reactive JJ cord-015021-pol2qm74 4578 22 protein protein NN cord-015021-pol2qm74 4578 23 ( ( -LRB- cord-015021-pol2qm74 4578 24 CRP CRP NNP cord-015021-pol2qm74 4578 25 ) ) -RRB- cord-015021-pol2qm74 4578 26 in in IN cord-015021-pol2qm74 4578 27 monitoring monitor VBG cord-015021-pol2qm74 4578 28 disease disease NN cord-015021-pol2qm74 4578 29 course course NN cord-015021-pol2qm74 4578 30 in in IN cord-015021-pol2qm74 4578 31 patients patient NNS cord-015021-pol2qm74 4578 32 with with IN cord-015021-pol2qm74 4578 33 multiple multiple JJ cord-015021-pol2qm74 4578 34 trauma trauma NN cord-015021-pol2qm74 4578 35 . . . cord-015021-pol2qm74 4579 1 We -PRON- PRP cord-015021-pol2qm74 4579 2 were be VBD cord-015021-pol2qm74 4579 3 interested interested JJ cord-015021-pol2qm74 4579 4 to to TO cord-015021-pol2qm74 4579 5 compare compare VB cord-015021-pol2qm74 4579 6 Nconcentrations Nconcentrations NNP cord-015021-pol2qm74 4579 7 as as IN cord-015021-pol2qm74 4579 8 marker marker NN cord-015021-pol2qm74 4579 9 of of IN cord-015021-pol2qm74 4579 10 T t NN cord-015021-pol2qm74 4579 11 - - HYPH cord-015021-pol2qm74 4579 12 cell cell NN cord-015021-pol2qm74 4579 13 / / SYM cord-015021-pol2qm74 4579 14 Macrophage macrophage NN cord-015021-pol2qm74 4579 15 activation activation NN cord-015021-pol2qm74 4579 16 with with IN cord-015021-pol2qm74 4579 17 CRP CRP NNP cord-015021-pol2qm74 4579 18 levels level NNS cord-015021-pol2qm74 4579 19 as as IN cord-015021-pol2qm74 4579 20 indicator indicator NN cord-015021-pol2qm74 4579 21 of of IN cord-015021-pol2qm74 4579 22 the the DT cord-015021-pol2qm74 4579 23 inflammatory inflammatory JJ cord-015021-pol2qm74 4579 24 acute acute JJ cord-015021-pol2qm74 4579 25 - - HYPH cord-015021-pol2qm74 4579 26 phase phase NN cord-015021-pol2qm74 4579 27 response response NN cord-015021-pol2qm74 4579 28 Daily Daily NNP cord-015021-pol2qm74 4579 29 serum serum NN cord-015021-pol2qm74 4579 30 concentrations(N concentrations(n NN cord-015021-pol2qm74 4579 31 and and CC cord-015021-pol2qm74 4579 32 CRP CRP NNP cord-015021-pol2qm74 4579 33 ) ) -RRB- cord-015021-pol2qm74 4579 34 were be VBD cord-015021-pol2qm74 4579 35 measured measure VBN cord-015021-pol2qm74 4579 36 in in IN cord-015021-pol2qm74 4579 37 12 12 CD cord-015021-pol2qm74 4579 38 patients patient NNS cord-015021-pol2qm74 4579 39 ( ( -LRB- cord-015021-pol2qm74 4579 40 9 9 CD cord-015021-pol2qm74 4579 41 male male NN cord-015021-pol2qm74 4579 42 , , , cord-015021-pol2qm74 4579 43 3 3 CD cord-015021-pol2qm74 4579 44 female female JJ cord-015021-pol2qm74 4579 45 , , , cord-015021-pol2qm74 4579 46 mean mean VB cord-015021-pol2qm74 4579 47 age age NN cord-015021-pol2qm74 4579 48 31.42 31.42 CD cord-015021-pol2qm74 4579 49 ) ) -RRB- cord-015021-pol2qm74 4579 50 , , , cord-015021-pol2qm74 4579 51 admitted admit VBN cord-015021-pol2qm74 4579 52 to to IN cord-015021-pol2qm74 4579 53 our -PRON- PRP$ cord-015021-pol2qm74 4579 54 ICU ICU NNP cord-015021-pol2qm74 4579 55 following follow VBG cord-015021-pol2qm74 4579 56 serious serious JJ cord-015021-pol2qm74 4579 57 trauma trauma NN cord-015021-pol2qm74 4579 58 ( ( -LRB- cord-015021-pol2qm74 4579 59 mean mean JJ cord-015021-pol2qm74 4579 60 ISS=34 ISS=34 NNP cord-015021-pol2qm74 4579 61 ) ) -RRB- cord-015021-pol2qm74 4579 62 and and CC cord-015021-pol2qm74 4579 63 in in IN cord-015021-pol2qm74 4579 64 10 10 CD cord-015021-pol2qm74 4579 65 control control NN cord-015021-pol2qm74 4579 66 subjects subject NNS cord-015021-pol2qm74 4579 67 . . . cord-015021-pol2qm74 4580 1 The the DT cord-015021-pol2qm74 4580 2 clinical clinical JJ cord-015021-pol2qm74 4580 3 course course NN cord-015021-pol2qm74 4580 4 of of IN cord-015021-pol2qm74 4580 5 each each DT cord-015021-pol2qm74 4580 6 patient patient NN cord-015021-pol2qm74 4580 7 was be VBD cord-015021-pol2qm74 4580 8 evaluated evaluate VBN cord-015021-pol2qm74 4580 9 with with IN cord-015021-pol2qm74 4580 10 APACHEII APACHEII NNP cord-015021-pol2qm74 4580 11 score score NN cord-015021-pol2qm74 4580 12 according accord VBG cord-015021-pol2qm74 4580 13 to to IN cord-015021-pol2qm74 4580 14 Knaus Knaus NNP cord-015021-pol2qm74 4580 15 . . . cord-015021-pol2qm74 4581 1 Mean mean VB cord-015021-pol2qm74 4581 2 stay stay VB cord-015021-pol2qm74 4581 3 in in IN cord-015021-pol2qm74 4581 4 ICU ICU NNP cord-015021-pol2qm74 4582 1 was be VBD cord-015021-pol2qm74 4582 2 9.25 9.25 CD cord-015021-pol2qm74 4582 3 ( ( -LRB- cord-015021-pol2qm74 4582 4 range range NNP cord-015021-pol2qm74 4582 5 5 5 CD cord-015021-pol2qm74 4582 6 - - SYM cord-015021-pol2qm74 4582 7 13 13 CD cord-015021-pol2qm74 4582 8 ) ) -RRB- cord-015021-pol2qm74 4582 9 . . . cord-015021-pol2qm74 4583 1 5 5 CD cord-015021-pol2qm74 4583 2 patients patient NNS cord-015021-pol2qm74 4583 3 did do VBD cord-015021-pol2qm74 4583 4 n't not RB cord-015021-pol2qm74 4583 5 develop develop VB cord-015021-pol2qm74 4583 6 organ organ NN cord-015021-pol2qm74 4583 7 failure(NOF failure(nof JJ cord-015021-pol2qm74 4583 8 - - HYPH cord-015021-pol2qm74 4583 9 group group NN cord-015021-pol2qm74 4583 10 ) ) -RRB- cord-015021-pol2qm74 4583 11 , , , cord-015021-pol2qm74 4583 12 4 4 CD cord-015021-pol2qm74 4583 13 patients patient NNS cord-015021-pol2qm74 4583 14 survived survive VBD cord-015021-pol2qm74 4583 15 , , , cord-015021-pol2qm74 4583 16 developing develop VBG cord-015021-pol2qm74 4583 17 MOF MOF NNP cord-015021-pol2qm74 4583 18 ( ( -LRB- cord-015021-pol2qm74 4583 19 S S NNP cord-015021-pol2qm74 4583 20 , , , cord-015021-pol2qm74 4583 21 MOF MOF NNP cord-015021-pol2qm74 4583 22 - - HYPH cord-015021-pol2qm74 4583 23 group group NNP cord-015021-pol2qm74 4583 24 ) ) -RRB- cord-015021-pol2qm74 4583 25 , , , cord-015021-pol2qm74 4583 26 3 3 CD cord-015021-pol2qm74 4583 27 patients patient NNS cord-015021-pol2qm74 4583 28 died die VBD cord-015021-pol2qm74 4583 29 with with IN cord-015021-pol2qm74 4583 30 MOF MOF NNP cord-015021-pol2qm74 4583 31 ( ( -LRB- cord-015021-pol2qm74 4583 32 NS NS NNP cord-015021-pol2qm74 4583 33 , , , cord-015021-pol2qm74 4583 34 MOFgroup MOFgroup NNP cord-015021-pol2qm74 4583 35 ) ) -RRB- cord-015021-pol2qm74 4583 36 . . . cord-015021-pol2qm74 4584 1 Three three CD cord-015021-pol2qm74 4584 2 patients(one patients(one NN cord-015021-pol2qm74 4584 3 S S NNP cord-015021-pol2qm74 4584 4 and and CC cord-015021-pol2qm74 4584 5 two two CD cord-015021-pol2qm74 4584 6 NS NS NNP cord-015021-pol2qm74 4584 7 ) ) -RRB- cord-015021-pol2qm74 4584 8 showed show VBD cord-015021-pol2qm74 4584 9 signs sign NNS cord-015021-pol2qm74 4584 10 of of IN cord-015021-pol2qm74 4584 11 septicemia septicemia NN cord-015021-pol2qm74 4584 12 and and CC cord-015021-pol2qm74 4584 13 septic septic JJ cord-015021-pol2qm74 4584 14 shock shock NN cord-015021-pol2qm74 4584 15 . . . cord-015021-pol2qm74 4585 1 The the DT cord-015021-pol2qm74 4585 2 serum serum NN cord-015021-pol2qm74 4585 3 samples sample NNS cord-015021-pol2qm74 4585 4 were be VBD cord-015021-pol2qm74 4585 5 measured measure VBN cord-015021-pol2qm74 4585 6 for for IN cord-015021-pol2qm74 4585 7 Neopterin Neopterin NNP cord-015021-pol2qm74 4585 8 ( ( -LRB- cord-015021-pol2qm74 4585 9 Immu Immu NNP cord-015021-pol2qm74 4585 10 - - HYPH cord-015021-pol2qm74 4585 11 Test Test NNP cord-015021-pol2qm74 4585 12 - - HYPH cord-015021-pol2qm74 4585 13 RIA RIA NNP cord-015021-pol2qm74 4585 14 , , , cord-015021-pol2qm74 4585 15 Henning Henning NNP cord-015021-pol2qm74 4585 16 - - HYPH cord-015021-pol2qm74 4585 17 Berlin Berlin NNP cord-015021-pol2qm74 4585 18 ) ) -RRB- cord-015021-pol2qm74 4585 19 and and CC cord-015021-pol2qm74 4585 20 for for IN cord-015021-pol2qm74 4585 21 CRP CRP NNP cord-015021-pol2qm74 4585 22 ( ( -LRB- cord-015021-pol2qm74 4585 23 immunoturbidimetric immunoturbidimetric JJ cord-015021-pol2qm74 4585 24 method method NN cord-015021-pol2qm74 4585 25 ) ) -RRB- cord-015021-pol2qm74 4585 26 -at -at NFP cord-015021-pol2qm74 4585 27 the the DT cord-015021-pol2qm74 4585 28 University University NNP cord-015021-pol2qm74 4585 29 Hospital Hospital NNP cord-015021-pol2qm74 4585 30 for for IN cord-015021-pol2qm74 4585 31 Internal Internal NNP cord-015021-pol2qm74 4585 32 Medicine Medicine NNP cord-015021-pol2qm74 4585 33 , , , cord-015021-pol2qm74 4585 34 Innsbruck Innsbruck NNP cord-015021-pol2qm74 4585 35 , , , cord-015021-pol2qm74 4585 36 Austria Austria NNP cord-015021-pol2qm74 4585 37 . . . cord-015021-pol2qm74 4586 1 The the DT cord-015021-pol2qm74 4586 2 highest high JJS cord-015021-pol2qm74 4586 3 CRP crp NN cord-015021-pol2qm74 4586 4 levels level NNS cord-015021-pol2qm74 4586 5 were be VBD cord-015021-pol2qm74 4586 6 measured measure VBN cord-015021-pol2qm74 4586 7 48h 48h NNS cord-015021-pol2qm74 4586 8 after after IN cord-015021-pol2qm74 4586 9 trauma trauma NN cord-015021-pol2qm74 4586 10 , , , cord-015021-pol2qm74 4586 11 but but CC cord-015021-pol2qm74 4586 12 they -PRON- PRP cord-015021-pol2qm74 4586 13 were be VBD cord-015021-pol2qm74 4586 14 not not RB cord-015021-pol2qm74 4586 15 accompanied accompany VBN cord-015021-pol2qm74 4586 16 by by IN cord-015021-pol2qm74 4586 17 significant significant JJ cord-015021-pol2qm74 4586 18 increase increase NN cord-015021-pol2qm74 4586 19 in in IN cord-015021-pol2qm74 4586 20 N n CD cord-015021-pol2qm74 4586 21 - - HYPH cord-015021-pol2qm74 4586 22 values value NNS cord-015021-pol2qm74 4586 23 . . . cord-015021-pol2qm74 4587 1 We -PRON- PRP cord-015021-pol2qm74 4587 2 found find VBD cord-015021-pol2qm74 4587 3 significantly significantly RB cord-015021-pol2qm74 4587 4 elevated elevate VBN cord-015021-pol2qm74 4587 5 N n CD cord-015021-pol2qm74 4587 6 - - HYPH cord-015021-pol2qm74 4587 7 concentrations concentration NNS cord-015021-pol2qm74 4587 8 from from IN cord-015021-pol2qm74 4587 9 the the DT cord-015021-pol2qm74 4587 10 days day NNS cord-015021-pol2qm74 4587 11 5 5 CD cord-015021-pol2qm74 4587 12 - - SYM cord-015021-pol2qm74 4587 13 6 6 CD cord-015021-pol2qm74 4587 14 . . . cord-015021-pol2qm74 4588 1 N N NNP cord-015021-pol2qm74 4588 2 and and CC cord-015021-pol2qm74 4588 3 CRP CRP NNP cord-015021-pol2qm74 4588 4 levels level NNS cord-015021-pol2qm74 4588 5 showed show VBD cord-015021-pol2qm74 4588 6 a a DT cord-015021-pol2qm74 4588 7 parallel parallel JJ cord-015021-pol2qm74 4588 8 release release NN cord-015021-pol2qm74 4588 9 peaks peak NNS cord-015021-pol2qm74 4588 10 on on IN cord-015021-pol2qm74 4588 11 the the DT cord-015021-pol2qm74 4588 12 days day NNS cord-015021-pol2qm74 4588 13 6 6 CD cord-015021-pol2qm74 4588 14 - - SYM cord-015021-pol2qm74 4588 15 7 7 CD cord-015021-pol2qm74 4588 16 and and CC cord-015021-pol2qm74 4588 17 the the DT cord-015021-pol2qm74 4588 18 values value NNS cord-015021-pol2qm74 4588 19 discriminated discriminate VBN cord-015021-pol2qm74 4588 20 significantly significantly RB cord-015021-pol2qm74 4588 21 among among IN cord-015021-pol2qm74 4588 22 the the DT cord-015021-pol2qm74 4588 23 three three CD cord-015021-pol2qm74 4588 24 outcome outcome NN cord-015021-pol2qm74 4588 25 groups(the groups(the DT cord-015021-pol2qm74 4588 26 second second JJ cord-015021-pol2qm74 4588 27 CRP CRP NNP cord-015021-pol2qm74 4588 28 peak peak NN cord-015021-pol2qm74 4588 29 is be VBZ cord-015021-pol2qm74 4588 30 lower low JJR cord-015021-pol2qm74 4588 31 in in IN cord-015021-pol2qm74 4588 32 comparison comparison NN cord-015021-pol2qm74 4588 33 to to IN cord-015021-pol2qm74 4588 34 the the DT cord-015021-pol2qm74 4588 35 first first JJ cord-015021-pol2qm74 4588 36 posttrauma posttrauma NNP cord-015021-pol2qm74 4588 37 peak peak NN cord-015021-pol2qm74 4588 38 ) ) -RRB- cord-015021-pol2qm74 4588 39 . . . cord-015021-pol2qm74 4589 1 By by IN cord-015021-pol2qm74 4589 2 the the DT cord-015021-pol2qm74 4589 3 NS NS NNP cord-015021-pol2qm74 4589 4 - - HYPH cord-015021-pol2qm74 4589 5 group group NN cord-015021-pol2qm74 4589 6 we -PRON- PRP cord-015021-pol2qm74 4589 7 found find VBD cord-015021-pol2qm74 4589 8 constant constant JJ cord-015021-pol2qm74 4589 9 and and CC cord-015021-pol2qm74 4589 10 parallel parallel JJ cord-015021-pol2qm74 4589 11 increasing increase VBG cord-015021-pol2qm74 4589 12 CRP CRP NNP cord-015021-pol2qm74 4589 13 and and CC cord-015021-pol2qm74 4589 14 N n CD cord-015021-pol2qm74 4589 15 levels level NNS cord-015021-pol2qm74 4589 16 , , , cord-015021-pol2qm74 4589 17 reaching reach VBG cord-015021-pol2qm74 4589 18 extremly extremly RB cord-015021-pol2qm74 4589 19 high high JJ cord-015021-pol2qm74 4589 20 values value NNS cord-015021-pol2qm74 4589 21 24 24 CD cord-015021-pol2qm74 4589 22 - - HYPH cord-015021-pol2qm74 4589 23 48h 48h NNS cord-015021-pol2qm74 4589 24 and and CC cord-015021-pol2qm74 4589 25 preceding precede VBG cord-015021-pol2qm74 4589 26 clinical clinical JJ cord-015021-pol2qm74 4589 27 signs sign NNS cord-015021-pol2qm74 4589 28 of of IN cord-015021-pol2qm74 4589 29 MOF MOF NNP cord-015021-pol2qm74 4589 30 and and CC cord-015021-pol2qm74 4589 31 sepsis sepsis NN cord-015021-pol2qm74 4589 32 . . . cord-015021-pol2qm74 4590 1 The the DT cord-015021-pol2qm74 4590 2 values value NNS cord-015021-pol2qm74 4590 3 increased increase VBD cord-015021-pol2qm74 4590 4 dramatically dramatically RB cord-015021-pol2qm74 4590 5 before before IN cord-015021-pol2qm74 4590 6 death death NN cord-015021-pol2qm74 4590 7 . . . cord-015021-pol2qm74 4591 1 The the DT cord-015021-pol2qm74 4591 2 serum serum NN cord-015021-pol2qm74 4591 3 levels level NNS cord-015021-pol2qm74 4591 4 by by IN cord-015021-pol2qm74 4591 5 all all DT cord-015021-pol2qm74 4591 6 10 10 CD cord-015021-pol2qm74 4591 7 control control NN cord-015021-pol2qm74 4591 8 subjects subject NNS cord-015021-pol2qm74 4591 9 were be VBD cord-015021-pol2qm74 4591 10 upper upper JJ cord-015021-pol2qm74 4591 11 the the DT cord-015021-pol2qm74 4591 12 normal normal JJ cord-015021-pol2qm74 4591 13 limit limit NN cord-015021-pol2qm74 4591 14 for for IN cord-015021-pol2qm74 4591 15 N N NNP cord-015021-pol2qm74 4591 16 and and CC cord-015021-pol2qm74 4591 17 CRP CRP NNP cord-015021-pol2qm74 4591 18 .. .. . cord-015021-pol2qm74 4592 1 The the DT cord-015021-pol2qm74 4592 2 parallel parallel JJ cord-015021-pol2qm74 4592 3 occured occur VBD cord-015021-pol2qm74 4592 4 peak peak NN cord-015021-pol2qm74 4592 5 changes change NNS cord-015021-pol2qm74 4592 6 in in IN cord-015021-pol2qm74 4592 7 N N NNP cord-015021-pol2qm74 4592 8 and and CC cord-015021-pol2qm74 4592 9 CRP CRP NNP cord-015021-pol2qm74 4592 10 concentrations concentration NNS cord-015021-pol2qm74 4592 11 showed show VBD cord-015021-pol2qm74 4592 12 a a DT cord-015021-pol2qm74 4592 13 significant significant JJ cord-015021-pol2qm74 4592 14 correlation correlation NN cord-015021-pol2qm74 4592 15 with with IN cord-015021-pol2qm74 4592 16 clinical clinical JJ cord-015021-pol2qm74 4592 17 status status NN cord-015021-pol2qm74 4592 18 , , , cord-015021-pol2qm74 4592 19 using use VBG cord-015021-pol2qm74 4592 20 a a DT cord-015021-pol2qm74 4592 21 disease disease NN cord-015021-pol2qm74 4592 22 activity activity NN cord-015021-pol2qm74 4592 23 score score NN cord-015021-pol2qm74 4592 24 ( ( -LRB- cord-015021-pol2qm74 4592 25 APAC APAC NNP cord-015021-pol2qm74 4592 26 H H NNP cord-015021-pol2qm74 4592 27 Eli Eli NNP cord-015021-pol2qm74 4592 28 ) ) -RRB- cord-015021-pol2qm74 4592 29 . . . cord-015021-pol2qm74 4593 1 Our -PRON- PRP$ cord-015021-pol2qm74 4593 2 findings finding NNS cord-015021-pol2qm74 4593 3 suggest suggest VBP cord-015021-pol2qm74 4593 4 that that IN cord-015021-pol2qm74 4593 5 both both DT cord-015021-pol2qm74 4593 6 - - HYPH cord-015021-pol2qm74 4593 7 cellular cellular JJ cord-015021-pol2qm74 4593 8 and and CC cord-015021-pol2qm74 4593 9 humoral humoral JJ cord-015021-pol2qm74 4593 10 mediated mediate VBN cord-015021-pol2qm74 4593 11 immune immune JJ cord-015021-pol2qm74 4593 12 mechanisms mechanism NNS cord-015021-pol2qm74 4593 13 are be VBP cord-015021-pol2qm74 4593 14 activated activate VBN cord-015021-pol2qm74 4593 15 after after IN cord-015021-pol2qm74 4593 16 multiple multiple JJ cord-015021-pol2qm74 4593 17 trauma trauma NN cord-015021-pol2qm74 4593 18 and and CC cord-015021-pol2qm74 4593 19 that that IN cord-015021-pol2qm74 4593 20 simultaneous simultaneous JJ cord-015021-pol2qm74 4593 21 determination determination NN cord-015021-pol2qm74 4593 22 of of IN cord-015021-pol2qm74 4593 23 N N NNP cord-015021-pol2qm74 4593 24 - - HYPH cord-015021-pol2qm74 4593 25 CRP CRP NNP cord-015021-pol2qm74 4593 26 may may MD cord-015021-pol2qm74 4593 27 be be VB cord-015021-pol2qm74 4593 28 of of IN cord-015021-pol2qm74 4593 29 advantage advantage NN cord-015021-pol2qm74 4593 30 as as IN cord-015021-pol2qm74 4593 31 diagnostic diagnostic JJ cord-015021-pol2qm74 4593 32 and and CC cord-015021-pol2qm74 4593 33 prognostic prognostic JJ cord-015021-pol2qm74 4593 34 parameter parameter NN cord-015021-pol2qm74 4593 35 in in IN cord-015021-pol2qm74 4593 36 polytrauma polytrauma NN cord-015021-pol2qm74 4593 37 - - HYPH cord-015021-pol2qm74 4593 38 patient patient JJ cord-015021-pol2qm74 4593 39 monitoring monitoring NN cord-015021-pol2qm74 4593 40 panel panel NN cord-015021-pol2qm74 4593 41 . . . cord-015021-pol2qm74 4594 1 It -PRON- PRP cord-015021-pol2qm74 4594 2 is be VBZ cord-015021-pol2qm74 4594 3 apparent apparent JJ cord-015021-pol2qm74 4594 4 , , , cord-015021-pol2qm74 4594 5 that that DT cord-015021-pol2qm74 4594 6 measurement measurement NN cord-015021-pol2qm74 4594 7 of of IN cord-015021-pol2qm74 4594 8 very very RB cord-015021-pol2qm74 4594 9 high high JJ cord-015021-pol2qm74 4594 10 levels level NNS cord-015021-pol2qm74 4594 11 may may MD cord-015021-pol2qm74 4594 12 be be VB cord-015021-pol2qm74 4594 13 of of IN cord-015021-pol2qm74 4594 14 value value NN cord-015021-pol2qm74 4594 15 as as IN cord-015021-pol2qm74 4594 16 a a DT cord-015021-pol2qm74 4594 17 srong srong JJ cord-015021-pol2qm74 4594 18 indicator indicator NN cord-015021-pol2qm74 4594 19 in in IN cord-015021-pol2qm74 4594 20 developing developing NN cord-015021-pol2qm74 4594 21 of of IN cord-015021-pol2qm74 4594 22 MOF MOF NNP cord-015021-pol2qm74 4594 23 or or CC cord-015021-pol2qm74 4594 24 septic septic JJ cord-015021-pol2qm74 4594 25 complications complication NNS cord-015021-pol2qm74 4594 26 and and CC cord-015021-pol2qm74 4594 27 thus thus RB cord-015021-pol2qm74 4594 28 offer offer VBP cord-015021-pol2qm74 4594 29 the the DT cord-015021-pol2qm74 4594 30 possibility possibility NN cord-015021-pol2qm74 4594 31 for for IN cord-015021-pol2qm74 4594 32 earlier early JJR cord-015021-pol2qm74 4594 33 therapeutic therapeutic JJ cord-015021-pol2qm74 4594 34 intervention intervention NN cord-015021-pol2qm74 4594 35 . . . cord-015021-pol2qm74 4595 1 The the DT cord-015021-pol2qm74 4595 2 modification modification NN cord-015021-pol2qm74 4595 3 of of IN cord-015021-pol2qm74 4595 4 T t NN cord-015021-pol2qm74 4595 5 - - HYPH cord-015021-pol2qm74 4595 6 cell cell NN cord-015021-pol2qm74 4595 7 / / SYM cord-015021-pol2qm74 4595 8 Macrophage macrophage NN cord-015021-pol2qm74 4595 9 and and CC cord-015021-pol2qm74 4595 10 acute acute JJ cord-015021-pol2qm74 4595 11 - - HYPH cord-015021-pol2qm74 4595 12 phase phase NN cord-015021-pol2qm74 4595 13 responses response NNS cord-015021-pol2qm74 4595 14 may may MD cord-015021-pol2qm74 4595 15 be be VB cord-015021-pol2qm74 4595 16 potentially potentially RB cord-015021-pol2qm74 4595 17 useful useful JJ cord-015021-pol2qm74 4595 18 in in IN cord-015021-pol2qm74 4595 19 the the DT cord-015021-pol2qm74 4595 20 treatment treatment NN cord-015021-pol2qm74 4595 21 of of IN cord-015021-pol2qm74 4595 22 ICU ICU NNP cord-015021-pol2qm74 4595 23 patients patient NNS cord-015021-pol2qm74 4595 24 , , , cord-015021-pol2qm74 4595 25 resuscitated resuscitate VBN cord-015021-pol2qm74 4595 26 after after IN cord-015021-pol2qm74 4595 27 severe severe JJ cord-015021-pol2qm74 4595 28 trauma trauma NN cord-015021-pol2qm74 4595 29 , , , cord-015021-pol2qm74 4595 30 and and CC cord-015021-pol2qm74 4595 31 suggest suggest VBP cord-015021-pol2qm74 4595 32 that that IN cord-015021-pol2qm74 4595 33 N N NNP cord-015021-pol2qm74 4595 34 - - HYPH cord-015021-pol2qm74 4595 35 CRP CRP NNP cord-015021-pol2qm74 4595 36 may may MD cord-015021-pol2qm74 4595 37 be be VB cord-015021-pol2qm74 4595 38 relevant relevant JJ cord-015021-pol2qm74 4595 39 indicator indicator NN cord-015021-pol2qm74 4595 40 for for IN cord-015021-pol2qm74 4595 41 testing test VBG cord-015021-pol2qm74 4595 42 experimental experimental JJ cord-015021-pol2qm74 4595 43 immunomodulating immunomodulating JJ cord-015021-pol2qm74 4595 44 therapies therapy NNS cord-015021-pol2qm74 4595 45 . . . cord-015021-pol2qm74 4596 1 Although although IN cord-015021-pol2qm74 4596 2 several several JJ cord-015021-pol2qm74 4596 3 in in IN cord-015021-pol2qm74 4596 4 vitro vitro FW cord-015021-pol2qm74 4596 5 studies study NNS cord-015021-pol2qm74 4596 6 suggested suggest VBD cord-015021-pol2qm74 4596 7 the the DT cord-015021-pol2qm74 4596 8 catalytic catalytic JJ cord-015021-pol2qm74 4596 9 action action NN cord-015021-pol2qm74 4596 10 of of IN cord-015021-pol2qm74 4596 11 iron iron NN cord-015021-pol2qm74 4596 12 in in IN cord-015021-pol2qm74 4596 13 oxygen oxygen NN cord-015021-pol2qm74 4596 14 free free JJ cord-015021-pol2qm74 4596 15 radical radical JJ cord-015021-pol2qm74 4596 16 generation generation NN cord-015021-pol2qm74 4596 17 , , , cord-015021-pol2qm74 4596 18 few few JJ cord-015021-pol2qm74 4596 19 data datum NNS cord-015021-pol2qm74 4596 20 are be VBP cord-015021-pol2qm74 4596 21 available available JJ cord-015021-pol2qm74 4596 22 concerning concern VBG cord-015021-pol2qm74 4596 23 iron iron NN cord-015021-pol2qm74 4596 24 - - HYPH cord-015021-pol2qm74 4596 25 metabolism metabolism NN cord-015021-pol2qm74 4596 26 following follow VBG cord-015021-pol2qm74 4596 27 ischemia ischemia NN cord-015021-pol2qm74 4596 28 - - HYPH cord-015021-pol2qm74 4596 29 reperfusion reperfusion NN cord-015021-pol2qm74 4596 30 injury injury NN cord-015021-pol2qm74 4596 31 and and CC cord-015021-pol2qm74 4596 32 hemorrhage hemorrhage NN cord-015021-pol2qm74 4596 33 in in IN cord-015021-pol2qm74 4596 34 vivo vivo NN cord-015021-pol2qm74 4596 35 . . . cord-015021-pol2qm74 4597 1 Aim aim VB cord-015021-pol2qm74 4597 2 of of IN cord-015021-pol2qm74 4597 3 the the DT cord-015021-pol2qm74 4597 4 present present JJ cord-015021-pol2qm74 4597 5 studies study NNS cord-015021-pol2qm74 4597 6 was be VBD cord-015021-pol2qm74 4597 7 to to TO cord-015021-pol2qm74 4597 8 evaluate evaluate VB cord-015021-pol2qm74 4597 9 iron iron NN cord-015021-pol2qm74 4597 10 metabolism metabolism NN cord-015021-pol2qm74 4597 11 following follow VBG cord-015021-pol2qm74 4597 12 mild mild JJ cord-015021-pol2qm74 4597 13 and and CC cord-015021-pol2qm74 4597 14 severe severe JJ cord-015021-pol2qm74 4597 15 hemorrhage hemorrhage NN cord-015021-pol2qm74 4597 16 in in IN cord-015021-pol2qm74 4597 17 the the DT cord-015021-pol2qm74 4597 18 presence presence NN cord-015021-pol2qm74 4597 19 and and CC cord-015021-pol2qm74 4597 20 absence absence NN cord-015021-pol2qm74 4597 21 of of IN cord-015021-pol2qm74 4597 22 intraperituneal intraperituneal NN cord-015021-pol2qm74 4597 23 hematoma hematoma NN cord-015021-pol2qm74 4597 24 . . . cord-015021-pol2qm74 4598 1 Methods method NNS cord-015021-pol2qm74 4598 2 . . . cord-015021-pol2qm74 4599 1 Male Male NNP cord-015021-pol2qm74 4599 2 Lewis Lewis NNP cord-015021-pol2qm74 4599 3 rats rat NNS cord-015021-pol2qm74 4599 4 ( ( -LRB- cord-015021-pol2qm74 4599 5 300 300 CD cord-015021-pol2qm74 4599 6 g g NN cord-015021-pol2qm74 4599 7 ) ) -RRB- cord-015021-pol2qm74 4599 8 divided divide VBD cord-015021-pol2qm74 4599 9 in in IN cord-015021-pol2qm74 4599 10 4 4 CD cord-015021-pol2qm74 4599 11 groups group NNS cord-015021-pol2qm74 4599 12 ( ( -LRB- cord-015021-pol2qm74 4599 13 observation observation NN cord-015021-pol2qm74 4599 14 time time NN cord-015021-pol2qm74 4599 15 120 120 CD cord-015021-pol2qm74 4599 16 hrs hrs NN cord-015021-pol2qm74 4599 17 ) ) -RRB- cord-015021-pol2qm74 4599 18 : : : cord-015021-pol2qm74 4600 1 A a DT cord-015021-pol2qm74 4600 2 : : : cord-015021-pol2qm74 4600 3 mild mild JJ cord-015021-pol2qm74 4600 4 hemorrhage hemorrhage NN cord-015021-pol2qm74 4600 5 by by IN cord-015021-pol2qm74 4600 6 sequential sequential JJ cord-015021-pol2qm74 4600 7 blood blood NN cord-015021-pol2qm74 4600 8 sampling sampling NN cord-015021-pol2qm74 4600 9 ( ( -LRB- cord-015021-pol2qm74 4600 10 0.9 0.9 CD cord-015021-pol2qm74 4600 11 ml ml NN cord-015021-pol2qm74 4600 12 each)(0 each)(0 NNP cord-015021-pol2qm74 4600 13 , , , cord-015021-pol2qm74 4600 14 2 2 CD cord-015021-pol2qm74 4600 15 , , , cord-015021-pol2qm74 4600 16 4 4 CD cord-015021-pol2qm74 4600 17 , , , cord-015021-pol2qm74 4600 18 6 6 CD cord-015021-pol2qm74 4600 19 , , , cord-015021-pol2qm74 4600 20 24 24 CD cord-015021-pol2qm74 4600 21 , , , cord-015021-pol2qm74 4600 22 48 48 CD cord-015021-pol2qm74 4600 23 , , , cord-015021-pol2qm74 4600 24 72 72 CD cord-015021-pol2qm74 4600 25 , , , cord-015021-pol2qm74 4600 26 96 96 CD cord-015021-pol2qm74 4600 27 , , , cord-015021-pol2qm74 4600 28 120 120 CD cord-015021-pol2qm74 4600 29 hrs hrs NN cord-015021-pol2qm74 4600 30 ) ) -RRB- cord-015021-pol2qm74 4600 31 . . . cord-015021-pol2qm74 4601 1 B b NN cord-015021-pol2qm74 4601 2 : : : cord-015021-pol2qm74 4602 1 A a DT cord-015021-pol2qm74 4602 2 with with IN cord-015021-pol2qm74 4602 3 hemoperitoneum hemoperitoneum NNP cord-015021-pol2qm74 4602 4 ( ( -LRB- cord-015021-pol2qm74 4602 5 HP)(2 HP)(2 NNP cord-015021-pol2qm74 4602 6 ml/100 ml/100 NNS cord-015021-pol2qm74 4602 7 g g NNP cord-015021-pol2qm74 4602 8 ) ) -RRB- cord-015021-pol2qm74 4602 9 , , , cord-015021-pol2qm74 4602 10 C c NN cord-015021-pol2qm74 4602 11 : : : cord-015021-pol2qm74 4602 12 hemorrhagic hemorrhagic JJ cord-015021-pol2qm74 4602 13 shock shock NN cord-015021-pol2qm74 4602 14 : : : cord-015021-pol2qm74 4602 15 blood blood NN cord-015021-pol2qm74 4602 16 withdrawal withdrawal NN cord-015021-pol2qm74 4602 17 of of IN cord-015021-pol2qm74 4602 18 3 3 CD cord-015021-pol2qm74 4602 19 ml/100 ml/100 NN cord-015021-pol2qm74 4602 20 g g NN cord-015021-pol2qm74 4602 21 over over IN cord-015021-pol2qm74 4602 22 30 30 CD cord-015021-pol2qm74 4602 23 min min NN cord-015021-pol2qm74 4602 24 and and CC cord-015021-pol2qm74 4602 25 resuscitation resuscitation NN cord-015021-pol2qm74 4602 26 with with IN cord-015021-pol2qm74 4602 27 Ringer Ringer NNP cord-015021-pol2qm74 4602 28 's 's POS cord-015021-pol2qm74 4602 29 lactate lactate NN cord-015021-pol2qm74 4602 30 ( ( -LRB- cord-015021-pol2qm74 4602 31 2 2 CD cord-015021-pol2qm74 4602 32 x x SYM cord-015021-pol2qm74 4602 33 shed shed JJ cord-015021-pol2qm74 4602 34 blood blood NN cord-015021-pol2qm74 4602 35 ) ) -RRB- cord-015021-pol2qm74 4602 36 and and CC cord-015021-pol2qm74 4602 37 isogenic isogenic JJ cord-015021-pol2qm74 4602 38 donor donor NN cord-015021-pol2qm74 4602 39 blood blood NN cord-015021-pol2qm74 4602 40 ; ; . cord-015021-pol2qm74 4603 1 D D NNP cord-015021-pol2qm74 4603 2 : : : cord-015021-pol2qm74 4603 3 C C NNP cord-015021-pol2qm74 4603 4 with with IN cord-015021-pol2qm74 4603 5 HP HP NNP cord-015021-pol2qm74 4603 6 . . . cord-015021-pol2qm74 4604 1 Parameters parameter NNS cord-015021-pol2qm74 4604 2 : : : cord-015021-pol2qm74 4604 3 serum serum NN cord-015021-pol2qm74 4604 4 iron iron NN cord-015021-pol2qm74 4604 5 ( ( -LRB- cord-015021-pol2qm74 4604 6 [ [ -LRB- cord-015021-pol2qm74 4604 7 g g NNP cord-015021-pol2qm74 4604 8 / / SYM cord-015021-pol2qm74 4604 9 dl dl NNP cord-015021-pol2qm74 4604 10 ] ] -RRB- cord-015021-pol2qm74 4604 11 , , , cord-015021-pol2qm74 4604 12 ferrozin ferrozin JJ cord-015021-pol2qm74 4604 13 - - HYPH cord-015021-pol2qm74 4604 14 method method NN cord-015021-pol2qm74 4604 15 ) ) -RRB- cord-015021-pol2qm74 4604 16 ; ; : cord-015021-pol2qm74 4604 17 59Fe 59fe CD cord-015021-pol2qm74 4604 18 labeling labeling NN cord-015021-pol2qm74 4604 19 of of IN cord-015021-pol2qm74 4604 20 erythrocytas erythrocytas NNP cord-015021-pol2qm74 4604 21 ( ( -LRB- cord-015021-pol2qm74 4604 22 application application NN cord-015021-pol2qm74 4604 23 of of IN cord-015021-pol2qm74 4604 24 1 1 CD cord-015021-pol2qm74 4604 25 Ci Ci NNP cord-015021-pol2qm74 4604 26 59Fe 59Fe NNP cord-015021-pol2qm74 4604 27 i.a i.a NNP cord-015021-pol2qm74 4604 28 . . NNP cord-015021-pol2qm74 4604 29 into into IN cord-015021-pol2qm74 4604 30 a a DT cord-015021-pol2qm74 4604 31 donor donor NN cord-015021-pol2qm74 4604 32 rat rat NN cord-015021-pol2qm74 4604 33 , , , cord-015021-pol2qm74 4604 34 5 5 CD cord-015021-pol2qm74 4604 35 days day NNS cord-015021-pol2qm74 4604 36 later later RB cord-015021-pol2qm74 4604 37 bleeding bleed VBG cord-015021-pol2qm74 4604 38 of of IN cord-015021-pol2qm74 4604 39 the the DT cord-015021-pol2qm74 4604 40 rat rat NN cord-015021-pol2qm74 4604 41 and and CC cord-015021-pol2qm74 4604 42 injection injection NN cord-015021-pol2qm74 4604 43 intraperitoneally intraperitoneally RB cord-015021-pol2qm74 4604 44 in in IN cord-015021-pol2qm74 4604 45 experimental experimental JJ cord-015021-pol2qm74 4604 46 rat rat NN cord-015021-pol2qm74 4604 47 ; ; : cord-015021-pol2qm74 4604 48 plasma plasma NN cord-015021-pol2qm74 4604 49 transferrin transferrin NN cord-015021-pol2qm74 4604 50 ( ( -LRB- cord-015021-pol2qm74 4604 51 [ [ -LRB- cord-015021-pol2qm74 4604 52 g g NN cord-015021-pol2qm74 4604 53 / / SYM cord-015021-pol2qm74 4604 54 ml ml NN cord-015021-pol2qm74 4604 55 ] ] -RRB- cord-015021-pol2qm74 4604 56 , , , cord-015021-pol2qm74 4604 57 RIA RIA NNP cord-015021-pol2qm74 4604 58 ) ) -RRB- cord-015021-pol2qm74 4604 59 . . . cord-015021-pol2qm74 4605 1 T t NN cord-015021-pol2qm74 4605 2 - - HYPH cord-015021-pol2qm74 4605 3 tests test NNS cord-015021-pol2qm74 4605 4 and and CC cord-015021-pol2qm74 4605 5 Mann Mann NNP cord-015021-pol2qm74 4605 6 Whitney Whitney NNP cord-015021-pol2qm74 4605 7 . . . cord-015021-pol2qm74 4606 1 Data datum NNS cord-015021-pol2qm74 4606 2 are be VBP cord-015021-pol2qm74 4606 3 expressed express VBN cord-015021-pol2qm74 4606 4 as as IN cord-015021-pol2qm74 4606 5 mean mean JJ cord-015021-pol2qm74 4606 6 + + CC cord-015021-pol2qm74 4606 7 SEM sem NN cord-015021-pol2qm74 4606 8 . . . cord-015021-pol2qm74 4607 1 Results result NNS cord-015021-pol2qm74 4607 2 . . . cord-015021-pol2qm74 4608 1 Compared compare VBN cord-015021-pol2qm74 4608 2 to to IN cord-015021-pol2qm74 4608 3 baseline baseline NN cord-015021-pol2qm74 4608 4 , , , cord-015021-pol2qm74 4608 5 mild mild JJ cord-015021-pol2qm74 4608 6 and and CC cord-015021-pol2qm74 4608 7 severe severe JJ cord-015021-pol2qm74 4608 8 hemorrhage hemorrhage NN cord-015021-pol2qm74 4608 9 caused cause VBD cord-015021-pol2qm74 4608 10 a a DT cord-015021-pol2qm74 4608 11 significant significant JJ cord-015021-pol2qm74 4608 12 increase increase NN cord-015021-pol2qm74 4608 13 in in IN cord-015021-pol2qm74 4608 14 serum serum NN cord-015021-pol2qm74 4608 15 iron iron NN cord-015021-pol2qm74 4608 16 at at IN cord-015021-pol2qm74 4608 17 24 24 CD cord-015021-pol2qm74 4608 18 and and CC cord-015021-pol2qm74 4608 19 48 48 CD cord-015021-pol2qm74 4608 20 hrs hrs NN cord-015021-pol2qm74 4608 21 , , , cord-015021-pol2qm74 4608 22 respectively respectively RB cord-015021-pol2qm74 4608 23 ( ( -LRB- cord-015021-pol2qm74 4608 24 212 212 CD cord-015021-pol2qm74 4608 25 + + SYM cord-015021-pol2qm74 4608 26 30 30 CD cord-015021-pol2qm74 4608 27 vs. vs. NN cord-015021-pol2qm74 4608 28 248 248 CD cord-015021-pol2qm74 4608 29 + + SYM cord-015021-pol2qm74 4608 30 35 35 CD cord-015021-pol2qm74 4608 31 ; ; : cord-015021-pol2qm74 4608 32 185+_28 185+_28 CD cord-015021-pol2qm74 4608 33 vs. vs. IN cord-015021-pol2qm74 4608 34 255+_22 255+_22 CD cord-015021-pol2qm74 4608 35 ) ) -RRB- cord-015021-pol2qm74 4608 36 . . . cord-015021-pol2qm74 4609 1 HP HP NNP cord-015021-pol2qm74 4609 2 reduced reduce VBD cord-015021-pol2qm74 4609 3 this this DT cord-015021-pol2qm74 4609 4 increase increase NN cord-015021-pol2qm74 4609 5 ( ( -LRB- cord-015021-pol2qm74 4609 6 209+_17 209+_17 CD cord-015021-pol2qm74 4609 7 vs. vs. FW cord-015021-pol2qm74 4609 8 177 177 CD cord-015021-pol2qm74 4609 9 + + SYM cord-015021-pol2qm74 4609 10 21 21 CD cord-015021-pol2qm74 4609 11 ; ; : cord-015021-pol2qm74 4609 12 194 194 CD cord-015021-pol2qm74 4609 13 + + SYM cord-015021-pol2qm74 4609 14 25 25 CD cord-015021-pol2qm74 4609 15 vs. vs. NN cord-015021-pol2qm74 4609 16 197 197 CD cord-015021-pol2qm74 4609 17 + + SYM cord-015021-pol2qm74 4609 18 -48 -48 NNP cord-015021-pol2qm74 4609 19 , , , cord-015021-pol2qm74 4609 20 p<.05 p<.05 NNP cord-015021-pol2qm74 4609 21 ) ) -RRB- cord-015021-pol2qm74 4609 22 . . . cord-015021-pol2qm74 4610 1 I -PRON- PRP cord-015021-pol2qm74 4610 2 - - HYPH cord-015021-pol2qm74 4610 3 IP IP NNP cord-015021-pol2qm74 4610 4 significantly significantly RB cord-015021-pol2qm74 4610 5 increased increase VBD cord-015021-pol2qm74 4610 6 hemoglobin hemoglobin NN cord-015021-pol2qm74 4610 7 between between IN cord-015021-pol2qm74 4610 8 24 24 CD cord-015021-pol2qm74 4610 9 to to TO cord-015021-pol2qm74 4610 10 96 96 CD cord-015021-pol2qm74 4610 11 hrs hrs NN cord-015021-pol2qm74 4610 12 in in IN cord-015021-pol2qm74 4610 13 mild mild JJ cord-015021-pol2qm74 4610 14 ( ( -LRB- cord-015021-pol2qm74 4610 15 12.1+_.8 12.1+_.8 JJ cord-015021-pol2qm74 4610 16 vs. vs. FW cord-015021-pol2qm74 4610 17 14.2+.7 14.2+.7 CD cord-015021-pol2qm74 4610 18 ) ) -RRB- cord-015021-pol2qm74 4610 19 and and CC cord-015021-pol2qm74 4610 20 severe severe JJ cord-015021-pol2qm74 4610 21 hemorrhage hemorrhage NN cord-015021-pol2qm74 4610 22 ( ( -LRB- cord-015021-pol2qm74 4610 23 10.3+.6 10.3+.6 CD cord-015021-pol2qm74 4610 24 vs. vs. IN cord-015021-pol2qm74 4610 25 13.1+.6 13.1+.6 CD cord-015021-pol2qm74 4610 26 ) ) -RRB- cord-015021-pol2qm74 4610 27 . . . cord-015021-pol2qm74 4611 1 In in IN cord-015021-pol2qm74 4611 2 mild mild JJ cord-015021-pol2qm74 4611 3 and and CC cord-015021-pol2qm74 4611 4 severe severe JJ cord-015021-pol2qm74 4611 5 hemorrhage hemorrhage NN cord-015021-pol2qm74 4611 6 comparable comparable JJ cord-015021-pol2qm74 4611 7 maximal maximal JJ cord-015021-pol2qm74 4611 8 resorption resorption NN cord-015021-pol2qm74 4611 9 ( ( -LRB- cord-015021-pol2qm74 4611 10 59Fe 59fe CD cord-015021-pol2qm74 4611 11 labeled label VBN cord-015021-pol2qm74 4611 12 erythrocytes erythrocyte NNS cord-015021-pol2qm74 4611 13 in in IN cord-015021-pol2qm74 4611 14 circulating circulate VBG cord-015021-pol2qm74 4611 15 blood blood NN cord-015021-pol2qm74 4611 16 ) ) -RRB- cord-015021-pol2qm74 4611 17 of of IN cord-015021-pol2qm74 4611 18 intraperitoneal intraperitoneal JJ cord-015021-pol2qm74 4611 19 hematoma hematoma NN cord-015021-pol2qm74 4611 20 occured occur VBD cord-015021-pol2qm74 4611 21 at at IN cord-015021-pol2qm74 4611 22 24 24 CD cord-015021-pol2qm74 4611 23 hrs hrs NN cord-015021-pol2qm74 4611 24 ( ( -LRB- cord-015021-pol2qm74 4611 25 mild mild JJ cord-015021-pol2qm74 4611 26 : : : cord-015021-pol2qm74 4611 27 318+_71 318+_71 CD cord-015021-pol2qm74 4611 28 vs. vs. IN cord-015021-pol2qm74 4611 29 severe severe JJ cord-015021-pol2qm74 4611 30 : : : cord-015021-pol2qm74 4612 1 364 364 CD cord-015021-pol2qm74 4612 2 + + SYM cord-015021-pol2qm74 4612 3 -114 -114 NNP cord-015021-pol2qm74 4612 4 counts count NNS cord-015021-pol2qm74 4612 5 / / SYM cord-015021-pol2qm74 4612 6 rain rain NN cord-015021-pol2qm74 4612 7 ) ) -RRB- cord-015021-pol2qm74 4612 8 . . . cord-015021-pol2qm74 4613 1 HP HP NNP cord-015021-pol2qm74 4613 2 increased increase VBD cord-015021-pol2qm74 4613 3 survival survival NN cord-015021-pol2qm74 4613 4 - - HYPH cord-015021-pol2qm74 4613 5 rate rate NN cord-015021-pol2qm74 4613 6 following follow VBG cord-015021-pol2qm74 4613 7 hemorrhagic hemorrhagic JJ cord-015021-pol2qm74 4613 8 shock shock NN cord-015021-pol2qm74 4613 9 ( ( -LRB- cord-015021-pol2qm74 4613 10 no no DT cord-015021-pol2qm74 4613 11 HP hp NN cord-015021-pol2qm74 4613 12 : : : cord-015021-pol2qm74 4613 13 10/17 10/17 CD cord-015021-pol2qm74 4613 14 ; ; : cord-015021-pol2qm74 4613 15 HP HP NNP cord-015021-pol2qm74 4613 16 : : : cord-015021-pol2qm74 4613 17 10/13 10/13 CD cord-015021-pol2qm74 4613 18 ) ) -RRB- cord-015021-pol2qm74 4613 19 . . . cord-015021-pol2qm74 4614 1 In in IN cord-015021-pol2qm74 4614 2 mild mild JJ cord-015021-pol2qm74 4614 3 hemorrhage hemorrhage NN cord-015021-pol2qm74 4614 4 no no DT cord-015021-pol2qm74 4614 5 alterations alteration NNS cord-015021-pol2qm74 4614 6 of of IN cord-015021-pol2qm74 4614 7 plasma plasma NN cord-015021-pol2qm74 4614 8 transferrin transferrin NN cord-015021-pol2qm74 4614 9 concentrations concentration NNS cord-015021-pol2qm74 4614 10 . . . cord-015021-pol2qm74 4615 1 In in IN cord-015021-pol2qm74 4615 2 shock shock NN cord-015021-pol2qm74 4615 3 group group NN cord-015021-pol2qm74 4615 4 without without IN cord-015021-pol2qm74 4615 5 HP HP NNP cord-015021-pol2qm74 4615 6 , , , cord-015021-pol2qm74 4615 7 there there EX cord-015021-pol2qm74 4615 8 was be VBD cord-015021-pol2qm74 4615 9 at at IN cord-015021-pol2qm74 4615 10 96 96 CD cord-015021-pol2qm74 4615 11 hrs hrs NN cord-015021-pol2qm74 4615 12 a a DT cord-015021-pol2qm74 4615 13 significant significant JJ cord-015021-pol2qm74 4615 14 higher high JJR cord-015021-pol2qm74 4615 15 transferrin transferrin NN cord-015021-pol2qm74 4615 16 level level NN cord-015021-pol2qm74 4615 17 than than IN cord-015021-pol2qm74 4615 18 with with IN cord-015021-pol2qm74 4615 19 HP HP NNP cord-015021-pol2qm74 4615 20 alone alone JJ cord-015021-pol2qm74 4616 1 ( ( -LRB- cord-015021-pol2qm74 4616 2 3.2+_.5 3.2+_.5 NNP cord-015021-pol2qm74 4616 3 vs. vs. NNP cord-015021-pol2qm74 4616 4 2.23 2.23 CD cord-015021-pol2qm74 4616 5 + + CD cord-015021-pol2qm74 4616 6 .2 .2 CD cord-015021-pol2qm74 4616 7 ) ) -RRB- cord-015021-pol2qm74 4616 8 . . . cord-015021-pol2qm74 4617 1 In in IN cord-015021-pol2qm74 4617 2 conclusion conclusion NN cord-015021-pol2qm74 4617 3 , , , cord-015021-pol2qm74 4617 4 hemoperitoneum hemoperitoneum NNP cord-015021-pol2qm74 4617 5 with with IN cord-015021-pol2qm74 4617 6 hemorrhage hemorrhage NN cord-015021-pol2qm74 4617 7 prevents prevent VBZ cord-015021-pol2qm74 4617 8 increase increase NN cord-015021-pol2qm74 4617 9 in in IN cord-015021-pol2qm74 4617 10 plasma plasma NN cord-015021-pol2qm74 4617 11 iron iron NN cord-015021-pol2qm74 4617 12 levels level NNS cord-015021-pol2qm74 4617 13 by by IN cord-015021-pol2qm74 4617 14 increasing increase VBG cord-015021-pol2qm74 4617 15 hemoglobin hemoglobin NN cord-015021-pol2qm74 4617 16 through through IN cord-015021-pol2qm74 4617 17 resorption resorption NN cord-015021-pol2qm74 4617 18 of of IN cord-015021-pol2qm74 4617 19 erythrocytes erythrocyte NNS cord-015021-pol2qm74 4617 20 and and CC cord-015021-pol2qm74 4617 21 thereby thereby RB cord-015021-pol2qm74 4617 22 suppressing suppress VBG cord-015021-pol2qm74 4617 23 iron iron NN cord-015021-pol2qm74 4617 24 mobilization mobilization NN cord-015021-pol2qm74 4617 25 from from IN cord-015021-pol2qm74 4617 26 endogenous endogenous JJ cord-015021-pol2qm74 4617 27 iron iron NN cord-015021-pol2qm74 4617 28 resources resource NNS cord-015021-pol2qm74 4617 29 , , , cord-015021-pol2qm74 4617 30 e.g. e.g. RB cord-015021-pol2qm74 4617 31 liver liver NN cord-015021-pol2qm74 4617 32 . . . cord-015021-pol2qm74 4618 1 This this DT cord-015021-pol2qm74 4618 2 suggests suggest VBZ cord-015021-pol2qm74 4618 3 that that IN cord-015021-pol2qm74 4618 4 intraperitoneal intraperitoneal JJ cord-015021-pol2qm74 4618 5 hematoma hematoma NN cord-015021-pol2qm74 4618 6 not not RB cord-015021-pol2qm74 4618 7 necessarily necessarily RB cord-015021-pol2qm74 4618 8 promotes promote VBZ cord-015021-pol2qm74 4618 9 iron iron NN cord-015021-pol2qm74 4618 10 - - HYPH cord-015021-pol2qm74 4618 11 mediated mediate VBN cord-015021-pol2qm74 4618 12 oxygen oxygen NN cord-015021-pol2qm74 4618 13 free free JJ cord-015021-pol2qm74 4618 14 radical radical JJ cord-015021-pol2qm74 4618 15 production production NN cord-015021-pol2qm74 4618 16 , , , cord-015021-pol2qm74 4618 17 especially especially RB cord-015021-pol2qm74 4618 18 since since IN cord-015021-pol2qm74 4618 19 survival survival NN cord-015021-pol2qm74 4618 20 in in IN cord-015021-pol2qm74 4618 21 these these DT cord-015021-pol2qm74 4618 22 groups group NNS cord-015021-pol2qm74 4618 23 was be VBD cord-015021-pol2qm74 4618 24 improved improve VBN cord-015021-pol2qm74 4618 25 . . . cord-015021-pol2qm74 4619 1 Increased increase VBN cord-015021-pol2qm74 4619 2 transfarrin transfarrin NN cord-015021-pol2qm74 4619 3 levels level NNS cord-015021-pol2qm74 4619 4 in in IN cord-015021-pol2qm74 4619 5 group group NN cord-015021-pol2qm74 4619 6 C c NN cord-015021-pol2qm74 4619 7 at at IN cord-015021-pol2qm74 4619 8 the the DT cord-015021-pol2qm74 4619 9 end end NN cord-015021-pol2qm74 4619 10 of of IN cord-015021-pol2qm74 4619 11 the the DT cord-015021-pol2qm74 4619 12 experiment experiment NN cord-015021-pol2qm74 4619 13 suggest suggest VBP cord-015021-pol2qm74 4619 14 increased increase VBN cord-015021-pol2qm74 4619 15 iron iron NN cord-015021-pol2qm74 4619 16 turnover turnover NN cord-015021-pol2qm74 4619 17 which which WDT cord-015021-pol2qm74 4619 18 was be VBD cord-015021-pol2qm74 4619 19 not not RB cord-015021-pol2qm74 4619 20 observed observe VBN cord-015021-pol2qm74 4619 21 in in IN cord-015021-pol2qm74 4619 22 shock shock NN cord-015021-pol2qm74 4619 23 groups group NNS cord-015021-pol2qm74 4619 24 associated associate VBN cord-015021-pol2qm74 4619 25 with with IN cord-015021-pol2qm74 4619 26 hemoperitoneum hemoperitoneum NNP cord-015021-pol2qm74 4619 27 . . . cord-015021-pol2qm74 4620 1 Primary primary JJ cord-015021-pol2qm74 4620 2 immune immune JJ cord-015021-pol2qm74 4620 3 response response NN cord-015021-pol2qm74 4620 4 to to IN cord-015021-pol2qm74 4620 5 thymus thymus NN cord-015021-pol2qm74 4620 6 - - HYPH cord-015021-pol2qm74 4620 7 dependent dependent JJ cord-015021-pol2qm74 4620 8 ( ( -LRB- cord-015021-pol2qm74 4620 9 SRBC SRBC NNP cord-015021-pol2qm74 4620 10 ) ) -RRB- cord-015021-pol2qm74 4620 11 and and CC cord-015021-pol2qm74 4620 12 thymus thymus NN cord-015021-pol2qm74 4620 13 - - HYPH cord-015021-pol2qm74 4620 14 independent independent JJ cord-015021-pol2qm74 4621 1 ( ( -LRB- cord-015021-pol2qm74 4621 2 Vi Vi NNP cord-015021-pol2qm74 4621 3 - - HYPH cord-015021-pol2qm74 4621 4 polysaccharide polysaccharide NN cord-015021-pol2qm74 4621 5 ) ) -RRB- cord-015021-pol2qm74 4621 6 antigens antigen NNS cord-015021-pol2qm74 4621 7 was be VBD cord-015021-pol2qm74 4621 8 determined determine VBN cord-015021-pol2qm74 4621 9 during during IN cord-015021-pol2qm74 4621 10 30 30 CD cord-015021-pol2qm74 4621 11 days day NNS cord-015021-pol2qm74 4621 12 after after IN cord-015021-pol2qm74 4621 13 CCT CCT NNP cord-015021-pol2qm74 4621 14 . . . cord-015021-pol2qm74 4622 1 Antigenic antigenic JJ cord-015021-pol2qm74 4622 2 challenge challenge NN cord-015021-pol2qm74 4622 3 was be VBD cord-015021-pol2qm74 4622 4 made make VBN cord-015021-pol2qm74 4622 5 on on IN cord-015021-pol2qm74 4622 6 day day NN cord-015021-pol2qm74 4622 7 i i PRP cord-015021-pol2qm74 4622 8 , , , cord-015021-pol2qm74 4622 9 5 5 CD cord-015021-pol2qm74 4622 10 , , , cord-015021-pol2qm74 4622 11 15 15 CD cord-015021-pol2qm74 4622 12 or or CC cord-015021-pol2qm74 4622 13 30 30 CD cord-015021-pol2qm74 4622 14 . . . cord-015021-pol2qm74 4623 1 Number number NN cord-015021-pol2qm74 4623 2 of of IN cord-015021-pol2qm74 4623 3 spleen spleen NN cord-015021-pol2qm74 4623 4 plaque plaque NN cord-015021-pol2qm74 4623 5 forming form VBG cord-015021-pol2qm74 4623 6 cells cell NNS cord-015021-pol2qm74 4623 7 ( ( -LRB- cord-015021-pol2qm74 4623 8 PFC PFC NNP cord-015021-pol2qm74 4623 9 ) ) -RRB- cord-015021-pol2qm74 4623 10 and and CC cord-015021-pol2qm74 4623 11 serum serum NN cord-015021-pol2qm74 4623 12 haemagglutinin haemagglutinin NNP cord-015021-pol2qm74 4623 13 ( ( -LRB- cord-015021-pol2qm74 4623 14 HA HA NNP cord-015021-pol2qm74 4623 15 ) ) -RRB- cord-015021-pol2qm74 4623 16 titre titre NN cord-015021-pol2qm74 4623 17 were be VBD cord-015021-pol2qm74 4623 18 studied study VBN cord-015021-pol2qm74 4623 19 on on IN cord-015021-pol2qm74 4623 20 day day NN cord-015021-pol2qm74 4623 21 5 5 CD cord-015021-pol2qm74 4623 22 after after IN cord-015021-pol2qm74 4623 23 immunization immunization NN cord-015021-pol2qm74 4623 24 . . . cord-015021-pol2qm74 4624 1 CCT CCT NNP cord-015021-pol2qm74 4624 2 stimulated stimulate VBD cord-015021-pol2qm74 4624 3 immune immune JJ cord-015021-pol2qm74 4624 4 response response NN cord-015021-pol2qm74 4624 5 to to IN cord-015021-pol2qm74 4624 6 T t NN cord-015021-pol2qm74 4624 7 - - HYPH cord-015021-pol2qm74 4624 8 dependent dependent JJ cord-015021-pol2qm74 4624 9 , , , cord-015021-pol2qm74 4624 10 but but CC cord-015021-pol2qm74 4624 11 not not RB cord-015021-pol2qm74 4624 12 to to IN cord-015021-pol2qm74 4624 13 T T NNP cord-015021-pol2qm74 4624 14 - - HYPH cord-015021-pol2qm74 4624 15 independent independent JJ cord-015021-pol2qm74 4624 16 antigen antigen NN cord-015021-pol2qm74 4624 17 . . . cord-015021-pol2qm74 4625 1 Enhanced enhanced JJ cord-015021-pol2qm74 4625 2 response response NN cord-015021-pol2qm74 4625 3 was be VBD cord-015021-pol2qm74 4625 4 noted note VBN cord-015021-pol2qm74 4625 5 when when WRB cord-015021-pol2qm74 4625 6 SRBS SRBS NNP cord-015021-pol2qm74 4625 7 were be VBD cord-015021-pol2qm74 4625 8 given give VBN cord-015021-pol2qm74 4625 9 in in IN cord-015021-pol2qm74 4625 10 posttraumatic posttraumatic JJ cord-015021-pol2qm74 4625 11 day day NN cord-015021-pol2qm74 4625 12 i i PRP cord-015021-pol2qm74 4625 13 , , , cord-015021-pol2qm74 4625 14 it -PRON- PRP cord-015021-pol2qm74 4625 15 was be VBD cord-015021-pol2qm74 4625 16 higher high JJR cord-015021-pol2qm74 4625 17 than than IN cord-015021-pol2qm74 4625 18 preceding precede VBG cord-015021-pol2qm74 4625 19 one one CD cord-015021-pol2qm74 4625 20 after after IN cord-015021-pol2qm74 4625 21 injection injection NN cord-015021-pol2qm74 4625 22 on on IN cord-015021-pol2qm74 4625 23 day day NN cord-015021-pol2qm74 4625 24 5 5 CD cord-015021-pol2qm74 4625 25 and and CC cord-015021-pol2qm74 4625 26 reached reach VBD cord-015021-pol2qm74 4625 27 a a DT cord-015021-pol2qm74 4625 28 maximum maximum NN cord-015021-pol2qm74 4625 29 when when WRB cord-015021-pol2qm74 4625 30 antigen antigen NN cord-015021-pol2qm74 4625 31 was be VBD cord-015021-pol2qm74 4625 32 presented present VBN cord-015021-pol2qm74 4625 33 on on IN cord-015021-pol2qm74 4625 34 day day NN cord-015021-pol2qm74 4625 35 15 15 CD cord-015021-pol2qm74 4625 36 after after IN cord-015021-pol2qm74 4625 37 trauma trauma NN cord-015021-pol2qm74 4626 1 ( ( -LRB- cord-015021-pol2qm74 4626 2 PFC PFC NNP cord-015021-pol2qm74 4626 3 number number NN cord-015021-pol2qm74 4626 4 2.4 2.4 CD cord-015021-pol2qm74 4626 5 times time NNS cord-015021-pol2qm74 4626 6 exceeded exceed VBD cord-015021-pol2qm74 4626 7 the the DT cord-015021-pol2qm74 4626 8 level level NN cord-015021-pol2qm74 4626 9 of of IN cord-015021-pol2qm74 4626 10 immunized immunize VBN cord-015021-pol2qm74 4626 11 , , , cord-015021-pol2qm74 4626 12 but but CC cord-015021-pol2qm74 4626 13 nontraumatized nontraumatized JJ cord-015021-pol2qm74 4626 14 rats rat NNS cord-015021-pol2qm74 4626 15 ) ) -RRB- cord-015021-pol2qm74 4626 16 . . . cord-015021-pol2qm74 4627 1 The the DT cord-015021-pol2qm74 4627 2 rise rise NN cord-015021-pol2qm74 4627 3 of of IN cord-015021-pol2qm74 4627 4 PFC PFC NNP cord-015021-pol2qm74 4627 5 number number NN cord-015021-pol2qm74 4627 6 in in IN cord-015021-pol2qm74 4627 7 spleen spleen NN cord-015021-pol2qm74 4627 8 correlated correlate VBN cord-015021-pol2qm74 4627 9 with with IN cord-015021-pol2qm74 4627 10 increased increase VBN cord-015021-pol2qm74 4627 11 HA HA NNP cord-015021-pol2qm74 4627 12 level level NN cord-015021-pol2qm74 4627 13 . . . cord-015021-pol2qm74 4628 1 Thymectomy Thymectomy NNP cord-015021-pol2qm74 4628 2 had have VBD cord-015021-pol2qm74 4628 3 been be VBN cord-015021-pol2qm74 4628 4 performed perform VBN cord-015021-pol2qm74 4628 5 30 30 CD cord-015021-pol2qm74 4628 6 days day NNS cord-015021-pol2qm74 4628 7 before before IN cord-015021-pol2qm74 4628 8 CCT CCT NNP cord-015021-pol2qm74 4628 9 completely completely RB cord-015021-pol2qm74 4628 10 abolished abolish VBD cord-015021-pol2qm74 4628 11 posttraumatio posttraumatio JJ cord-015021-pol2qm74 4628 12 stimulation stimulation NN cord-015021-pol2qm74 4628 13 of of IN cord-015021-pol2qm74 4628 14 immune immune JJ cord-015021-pol2qm74 4628 15 response response NN cord-015021-pol2qm74 4628 16 to to IN cord-015021-pol2qm74 4628 17 T t NN cord-015021-pol2qm74 4628 18 - - HYPH cord-015021-pol2qm74 4628 19 dependent dependent JJ cord-015021-pol2qm74 4628 20 antigen antigen NN cord-015021-pol2qm74 4628 21 . . . cord-015021-pol2qm74 4629 1 Standard standard JJ cord-015021-pol2qm74 4629 2 thoracotomy thoracotomy NN cord-015021-pol2qm74 4629 3 also also RB cord-015021-pol2qm74 4629 4 enhanced enhance VBD cord-015021-pol2qm74 4629 5 humoral humoral JJ cord-015021-pol2qm74 4629 6 response response NN cord-015021-pol2qm74 4629 7 when when WRB cord-015021-pol2qm74 4629 8 SRBC SRBC NNP cord-015021-pol2qm74 4629 9 were be VBD cord-015021-pol2qm74 4629 10 administered administer VBN cord-015021-pol2qm74 4629 11 on on IN cord-015021-pol2qm74 4629 12 day day NN cord-015021-pol2qm74 4629 13 15 15 CD cord-015021-pol2qm74 4629 14 after after IN cord-015021-pol2qm74 4629 15 the the DT cord-015021-pol2qm74 4629 16 operation operation NN cord-015021-pol2qm74 4629 17 . . . cord-015021-pol2qm74 4630 1 Thymus thymus NN cord-015021-pol2qm74 4630 2 trauma trauma NN cord-015021-pol2qm74 4630 3 modeled model VBN cord-015021-pol2qm74 4630 4 by by IN cord-015021-pol2qm74 4630 5 pincett pincett NN cord-015021-pol2qm74 4630 6 squeezing squeezing NN cord-015021-pol2qm74 4630 7 of of IN cord-015021-pol2qm74 4630 8 its -PRON- PRP$ cord-015021-pol2qm74 4630 9 right right JJ cord-015021-pol2qm74 4630 10 lobe lobe NN cord-015021-pol2qm74 4630 11 and and CC cord-015021-pol2qm74 4630 12 performed perform VBD cord-015021-pol2qm74 4630 13 at at IN cord-015021-pol2qm74 4630 14 the the DT cord-015021-pol2qm74 4630 15 same same JJ cord-015021-pol2qm74 4630 16 time time NN cord-015021-pol2qm74 4630 17 with with IN cord-015021-pol2qm74 4630 18 thoracotomy thoracotomy NN cord-015021-pol2qm74 4630 19 fully fully RB cord-015021-pol2qm74 4630 20 abrogated abrogate VBD cord-015021-pol2qm74 4630 21 as as RB cord-015021-pol2qm74 4630 22 well well RB cord-015021-pol2qm74 4630 23 as as IN cord-015021-pol2qm74 4630 24 thymectomy thymectomy NN cord-015021-pol2qm74 4630 25 stimulation stimulation NN cord-015021-pol2qm74 4630 26 of of IN cord-015021-pol2qm74 4630 27 immune immune JJ cord-015021-pol2qm74 4630 28 reaction reaction NN cord-015021-pol2qm74 4630 29 . . . cord-015021-pol2qm74 4631 1 Thus thus RB cord-015021-pol2qm74 4631 2 , , , cord-015021-pol2qm74 4631 3 different different JJ cord-015021-pol2qm74 4631 4 experimental experimental JJ cord-015021-pol2qm74 4631 5 chest chest NN cord-015021-pol2qm74 4631 6 traumas trauma NNS cord-015021-pol2qm74 4631 7 are be VBP cord-015021-pol2qm74 4631 8 able able JJ cord-015021-pol2qm74 4631 9 to to TO cord-015021-pol2qm74 4631 10 increase increase VB cord-015021-pol2qm74 4631 11 antibody antibody NN cord-015021-pol2qm74 4631 12 production production NN cord-015021-pol2qm74 4631 13 via via IN cord-015021-pol2qm74 4631 14 thymus thymus NN cord-015021-pol2qm74 4631 15 - - HYPH cord-015021-pol2qm74 4631 16 dependent dependent JJ cord-015021-pol2qm74 4631 17 mechanisms mechanism NNS cord-015021-pol2qm74 4631 18 . . . cord-015021-pol2qm74 4632 1 Endothelin Endothelin NNP cord-015021-pol2qm74 4632 2 is be VBZ cord-015021-pol2qm74 4632 3 a a DT cord-015021-pol2qm74 4632 4 21 21 CD cord-015021-pol2qm74 4632 5 amino amino NN cord-015021-pol2qm74 4632 6 acid acid NN cord-015021-pol2qm74 4632 7 peptide peptide NN cord-015021-pol2qm74 4632 8 produced produce VBN cord-015021-pol2qm74 4632 9 by by IN cord-015021-pol2qm74 4632 10 ischemic ischemic JJ cord-015021-pol2qm74 4632 11 or or CC cord-015021-pol2qm74 4632 12 injured injure VBN cord-015021-pol2qm74 4632 13 endothelial endothelial JJ cord-015021-pol2qm74 4632 14 cells cell NNS cord-015021-pol2qm74 4632 15 . . . cord-015021-pol2qm74 4633 1 In in IN cord-015021-pol2qm74 4633 2 vitro vitro FW cord-015021-pol2qm74 4633 3 and and CC cord-015021-pol2qm74 4633 4 in in IN cord-015021-pol2qm74 4633 5 animal animal NN cord-015021-pol2qm74 4633 6 studies study NNS cord-015021-pol2qm74 4633 7 , , , cord-015021-pol2qm74 4633 8 ET ET NNP cord-015021-pol2qm74 4633 9 is be VBZ cord-015021-pol2qm74 4633 10 also also RB cord-015021-pol2qm74 4633 11 a a DT cord-015021-pol2qm74 4633 12 potent potent JJ cord-015021-pol2qm74 4633 13 constrictor constrictor NN cord-015021-pol2qm74 4633 14 for for IN cord-015021-pol2qm74 4633 15 renal renal JJ cord-015021-pol2qm74 4633 16 mesangial mesangial JJ cord-015021-pol2qm74 4633 17 and and CC cord-015021-pol2qm74 4633 18 coronary coronary JJ cord-015021-pol2qm74 4633 19 vessels vessel NNS cord-015021-pol2qm74 4633 20 , , , cord-015021-pol2qm74 4633 21 a a DT cord-015021-pol2qm74 4633 22 negative negative JJ cord-015021-pol2qm74 4633 23 cardiac cardiac JJ cord-015021-pol2qm74 4633 24 inotrope inotrope NN cord-015021-pol2qm74 4633 25 and and CC cord-015021-pol2qm74 4633 26 an an DT cord-015021-pol2qm74 4633 27 endocrine endocrine JJ cord-015021-pol2qm74 4633 28 regulator regulator NN cord-015021-pol2qm74 4633 29 . . . cord-015021-pol2qm74 4634 1 Our -PRON- PRP$ cord-015021-pol2qm74 4634 2 lab lab NN cord-015021-pol2qm74 4634 3 has have VBZ cord-015021-pol2qm74 4634 4 shown show VBN cord-015021-pol2qm74 4634 5 that that IN cord-015021-pol2qm74 4634 6 ET ET NNP cord-015021-pol2qm74 4634 7 is be VBZ cord-015021-pol2qm74 4634 8 an an DT cord-015021-pol2qm74 4634 9 agonist agonist NN cord-015021-pol2qm74 4634 10 for for IN cord-015021-pol2qm74 4634 11 monocyte monocyte JJ cord-015021-pol2qm74 4634 12 production production NN cord-015021-pol2qm74 4634 13 of of IN cord-015021-pol2qm74 4634 14 interleukins interleukin NNS cord-015021-pol2qm74 4634 15 i i PRP cord-015021-pol2qm74 4634 16 , , , cord-015021-pol2qm74 4634 17 6 6 CD cord-015021-pol2qm74 4634 18 & & CC cord-015021-pol2qm74 4634 19 8 8 CD cord-015021-pol2qm74 4634 20 , , , cord-015021-pol2qm74 4634 21 prostaglandin prostaglandin NN cord-015021-pol2qm74 4634 22 E e NN cord-015021-pol2qm74 4634 23 2 2 CD cord-015021-pol2qm74 4634 24 ( ( -LRB- cord-015021-pol2qm74 4634 25 PGE2 PGE2 NNP cord-015021-pol2qm74 4634 26 ) ) -RRB- cord-015021-pol2qm74 4634 27 , , , cord-015021-pol2qm74 4634 28 and and CC cord-015021-pol2qm74 4634 29 substances substance NNS cord-015021-pol2qm74 4634 30 which which WDT cord-015021-pol2qm74 4634 31 trigger trigger VBP cord-015021-pol2qm74 4634 32 superoxide superoxide NN cord-015021-pol2qm74 4634 33 production production NN cord-015021-pol2qm74 4634 34 . . . cord-015021-pol2qm74 4635 1 Systemic systemic JJ cord-015021-pol2qm74 4635 2 ET ET NNP cord-015021-pol2qm74 4635 3 levels level NNS cord-015021-pol2qm74 4635 4 increase increase NN cord-015021-pol2qm74 4635 5 in in IN cord-015021-pol2qm74 4635 6 hypoperfused hypoperfused JJ cord-015021-pol2qm74 4635 7 and and CC cord-015021-pol2qm74 4635 8 septic septic JJ cord-015021-pol2qm74 4635 9 patients patient NNS cord-015021-pol2qm74 4635 10 , , , cord-015021-pol2qm74 4635 11 and and CC cord-015021-pol2qm74 4635 12 ET ET NNP cord-015021-pol2qm74 4635 13 may may MD cord-015021-pol2qm74 4635 14 be be VB cord-015021-pol2qm74 4635 15 yet yet RB cord-015021-pol2qm74 4635 16 another another DT cord-015021-pol2qm74 4635 17 important important JJ cord-015021-pol2qm74 4635 18 cytokine cytokine NN cord-015021-pol2qm74 4635 19 in in IN cord-015021-pol2qm74 4635 20 critical critical JJ cord-015021-pol2qm74 4635 21 illness illness NN cord-015021-pol2qm74 4635 22 . . . cord-015021-pol2qm74 4636 1 But but CC cord-015021-pol2qm74 4636 2 while while IN cord-015021-pol2qm74 4636 3 ET ET NNP cord-015021-pol2qm74 4636 4 has have VBZ cord-015021-pol2qm74 4636 5 been be VBN cord-015021-pol2qm74 4636 6 shown show VBN cord-015021-pol2qm74 4636 7 to to TO cord-015021-pol2qm74 4636 8 be be VB cord-015021-pol2qm74 4636 9 a a DT cord-015021-pol2qm74 4636 10 potent potent JJ cord-015021-pol2qm74 4636 11 vasoconstrictor vasoconstrictor NN cord-015021-pol2qm74 4636 12 in in IN cord-015021-pol2qm74 4636 13 healthy healthy JJ cord-015021-pol2qm74 4636 14 dogs dog NNS cord-015021-pol2qm74 4636 15 , , , cord-015021-pol2qm74 4636 16 systemic systemic JJ cord-015021-pol2qm74 4636 17 vascular vascular JJ cord-015021-pol2qm74 4636 18 resistance resistance NN cord-015021-pol2qm74 4636 19 does do VBZ cord-015021-pol2qm74 4636 20 not not RB cord-015021-pol2qm74 4636 21 increase increase VB cord-015021-pol2qm74 4636 22 in in IN cord-015021-pol2qm74 4636 23 critically critically RB cord-015021-pol2qm74 4636 24 ill ill JJ cord-015021-pol2qm74 4636 25 patients patient NNS cord-015021-pol2qm74 4636 26 with with IN cord-015021-pol2qm74 4636 27 high high JJ cord-015021-pol2qm74 4636 28 ET ET NNP cord-015021-pol2qm74 4636 29 levels level NNS cord-015021-pol2qm74 4636 30 . . . cord-015021-pol2qm74 4637 1 ( ( -LRB- cord-015021-pol2qm74 4637 2 We -PRON- PRP cord-015021-pol2qm74 4637 3 hypothesize hypothesize VBP cord-015021-pol2qm74 4637 4 that that IN cord-015021-pol2qm74 4637 5 this this DT cord-015021-pol2qm74 4637 6 might may MD cord-015021-pol2qm74 4637 7 be be VB cord-015021-pol2qm74 4637 8 due due JJ cord-015021-pol2qm74 4637 9 to to IN cord-015021-pol2qm74 4637 10 PGEz PGEz NNS cord-015021-pol2qm74 4637 11 - - HYPH cord-015021-pol2qm74 4637 12 mediated mediate VBN cord-015021-pol2qm74 4637 13 vasodilation vasodilation NN cord-015021-pol2qm74 4637 14 predominating predominate VBG cord-015021-pol2qm74 4637 15 over over IN cord-015021-pol2qm74 4637 16 ET et NN cord-015021-pol2qm74 4637 17 - - HYPH cord-015021-pol2qm74 4637 18 mediated mediate VBN cord-015021-pol2qm74 4637 19 vasoconstriction vasoconstriction NN cord-015021-pol2qm74 4637 20 . . . cord-015021-pol2qm74 4637 21 ) ) -RRB- cord-015021-pol2qm74 4638 1 We -PRON- PRP cord-015021-pol2qm74 4638 2 next next RB cord-015021-pol2qm74 4638 3 asked ask VBD cord-015021-pol2qm74 4638 4 what what WP cord-015021-pol2qm74 4638 5 happened happen VBD cord-015021-pol2qm74 4638 6 to to IN cord-015021-pol2qm74 4638 7 systemic systemic JJ cord-015021-pol2qm74 4638 8 ET ET NNP cord-015021-pol2qm74 4638 9 levels level NNS cord-015021-pol2qm74 4638 10 in in IN cord-015021-pol2qm74 4638 11 patients patient NNS cord-015021-pol2qm74 4638 12 with with IN cord-015021-pol2qm74 4638 13 major major JJ cord-015021-pol2qm74 4638 14 burns burn NNS cord-015021-pol2qm74 4638 15 ( ( -LRB- cord-015021-pol2qm74 4638 16 > > NFP cord-015021-pol2qm74 4638 17 20 20 CD cord-015021-pol2qm74 4638 18 % % NN cord-015021-pol2qm74 4638 19 . . . cord-015021-pol2qm74 4638 20 ) ) -RRB- cord-015021-pol2qm74 4639 1 Ten ten CD cord-015021-pol2qm74 4639 2 hemodynamically hemodynamically RB cord-015021-pol2qm74 4639 3 stable stable JJ cord-015021-pol2qm74 4639 4 patients patient NNS cord-015021-pol2qm74 4639 5 resuscitated resuscitate VBN cord-015021-pol2qm74 4639 6 by by IN cord-015021-pol2qm74 4639 7 a a DT cord-015021-pol2qm74 4639 8 modified modify VBN cord-015021-pol2qm74 4639 9 Parkland Parkland NNP cord-015021-pol2qm74 4639 10 formula formula NN cord-015021-pol2qm74 4639 11 to to IN cord-015021-pol2qm74 4639 12 a a DT cord-015021-pol2qm74 4639 13 urine urine NN cord-015021-pol2qm74 4639 14 output output NN cord-015021-pol2qm74 4639 15 > > XX cord-015021-pol2qm74 4639 16 30 30 CD cord-015021-pol2qm74 4639 17 cc cc NN cord-015021-pol2qm74 4639 18 's 's NN cord-015021-pol2qm74 4639 19 per per IN cord-015021-pol2qm74 4639 20 hour hour NN cord-015021-pol2qm74 4639 21 had have VBD cord-015021-pol2qm74 4639 22 ET ET NNP cord-015021-pol2qm74 4639 23 levels level NNS cord-015021-pol2qm74 4639 24 drawn draw VBN cord-015021-pol2qm74 4639 25 on on IN cord-015021-pol2qm74 4639 26 admission admission NN cord-015021-pol2qm74 4639 27 , , , cord-015021-pol2qm74 4639 28 at at IN cord-015021-pol2qm74 4639 29 i i PRP cord-015021-pol2qm74 4639 30 , , , cord-015021-pol2qm74 4639 31 6 6 CD cord-015021-pol2qm74 4639 32 12 12 CD cord-015021-pol2qm74 4639 33 , , , cord-015021-pol2qm74 4639 34 24 24 CD cord-015021-pol2qm74 4639 35 , , , cord-015021-pol2qm74 4639 36 and and CC cord-015021-pol2qm74 4639 37 48 48 CD cord-015021-pol2qm74 4639 38 hrs hrs NN cord-015021-pol2qm74 4639 39 . . . cord-015021-pol2qm74 4640 1 ET ET NNP cord-015021-pol2qm74 4640 2 levels level NNS cord-015021-pol2qm74 4640 3 were be VBD cord-015021-pol2qm74 4640 4 measured measure VBN cord-015021-pol2qm74 4640 5 by by IN cord-015021-pol2qm74 4640 6 radioimmunoassay radioimmunoassay JJ cord-015021-pol2qm74 4640 7 . . . cord-015021-pol2qm74 4641 1 Mean mean JJ cord-015021-pol2qm74 4641 2 levels level NNS cord-015021-pol2qm74 4641 3 were be VBD cord-015021-pol2qm74 4641 4 elevated elevate VBN cord-015021-pol2qm74 4641 5 at at IN cord-015021-pol2qm74 4641 6 205±28 205±28 CD cord-015021-pol2qm74 4641 7 pg pg NNP cord-015021-pol2qm74 4641 8 / / SYM cord-015021-pol2qm74 4641 9 ml ml XX cord-015021-pol2qm74 4641 10 at at RB cord-015021-pol2qm74 4641 11 all all DT cord-015021-pol2qm74 4641 12 time time NN cord-015021-pol2qm74 4641 13 points point NNS cord-015021-pol2qm74 4641 14 versus versus IN cord-015021-pol2qm74 4641 15 levels level NNS cord-015021-pol2qm74 4641 16 in in IN cord-015021-pol2qm74 4641 17 healthy healthy JJ cord-015021-pol2qm74 4641 18 controls control NNS cord-015021-pol2qm74 4641 19 of of IN cord-015021-pol2qm74 4641 20 39±9 39±9 CD cord-015021-pol2qm74 4641 21 . . . cord-015021-pol2qm74 4642 1 In in IN cord-015021-pol2qm74 4642 2 summary summary NN cord-015021-pol2qm74 4642 3 , , , cord-015021-pol2qm74 4642 4 systemic systemic JJ cord-015021-pol2qm74 4642 5 ET ET NNP cord-015021-pol2qm74 4642 6 levels level NNS cord-015021-pol2qm74 4642 7 increase increase VBP cord-015021-pol2qm74 4642 8 significantly significantly RB cord-015021-pol2qm74 4642 9 in in IN cord-015021-pol2qm74 4642 10 patients patient NNS cord-015021-pol2qm74 4642 11 with with IN cord-015021-pol2qm74 4642 12 major major JJ cord-015021-pol2qm74 4642 13 burns burn NNS cord-015021-pol2qm74 4642 14 . . . cord-015021-pol2qm74 4643 1 ET ET NNP cord-015021-pol2qm74 4643 2 may may MD cord-015021-pol2qm74 4643 3 be be VB cord-015021-pol2qm74 4643 4 yet yet RB cord-015021-pol2qm74 4643 5 another another DT cord-015021-pol2qm74 4643 6 cytokine cytokine NN cord-015021-pol2qm74 4643 7 playing play VBG cord-015021-pol2qm74 4643 8 a a DT cord-015021-pol2qm74 4643 9 significant significant JJ cord-015021-pol2qm74 4643 10 role role NN cord-015021-pol2qm74 4643 11 in in IN cord-015021-pol2qm74 4643 12 the the DT cord-015021-pol2qm74 4643 13 immune immune JJ cord-015021-pol2qm74 4643 14 , , , cord-015021-pol2qm74 4643 15 inflammatory inflammatory JJ cord-015021-pol2qm74 4643 16 and and CC cord-015021-pol2qm74 4643 17 multiorgan multiorgan NNP cord-015021-pol2qm74 4643 18 dysfunction dysfunction NN cord-015021-pol2qm74 4643 19 observed observe VBN cord-015021-pol2qm74 4643 20 with with IN cord-015021-pol2qm74 4643 21 major major JJ cord-015021-pol2qm74 4643 22 burns burn NNS cord-015021-pol2qm74 4643 23 . . . cord-015021-pol2qm74 4644 1 Restoration restoration NN cord-015021-pol2qm74 4644 2 processes process NNS cord-015021-pol2qm74 4644 3 in in IN cord-015021-pol2qm74 4644 4 an an DT cord-015021-pol2qm74 4644 5 organism organism NN cord-015021-pol2qm74 4644 6 after after IN cord-015021-pol2qm74 4644 7 ischemic ischemic JJ cord-015021-pol2qm74 4644 8 damage damage NN cord-015021-pol2qm74 4644 9 are be VBP cord-015021-pol2qm74 4644 10 realized realize VBN cord-015021-pol2qm74 4644 11 through through IN cord-015021-pol2qm74 4645 1 ~n ~n NNP cord-015021-pol2qm74 4646 1 ~lammatory ~lammatory NNP cord-015021-pol2qm74 4646 2 mechanisms~ mechanisms~ NN cord-015021-pol2qm74 4647 1 the the DT cord-015021-pol2qm74 4647 2 intensity intensity NN cord-015021-pol2qm74 4647 3 of of IN cord-015021-pol2qm74 4647 4 which which WDT cord-015021-pol2qm74 4647 5 is be VBZ cord-015021-pol2qm74 4647 6 significantly significantly RB cord-015021-pol2qm74 4647 7 defined define VBN cord-015021-pol2qm74 4647 8 by by IN cord-015021-pol2qm74 4647 9 blood blood NN cord-015021-pol2qm74 4647 10 levels level NNS cord-015021-pol2qm74 4647 11 of of IN cord-015021-pol2qm74 4647 12 neuropeptides neuropeptide NNS cord-015021-pol2qm74 4647 13 . . . cord-015021-pol2qm74 4648 1 Myocardial myocardial JJ cord-015021-pol2qm74 4648 2 infarction infarction NN cord-015021-pol2qm74 4648 3 ( ( -LRB- cord-015021-pol2qm74 4648 4 MI MI NNP cord-015021-pol2qm74 4648 5 ) ) -RRB- cord-015021-pol2qm74 4648 6 was be VBD cord-015021-pol2qm74 4648 7 chosen choose VBN cord-015021-pol2qm74 4648 8 for for IN cord-015021-pol2qm74 4648 9 studyin studyin NNP cord-015021-pol2qm74 4648 10 9 9 CD cord-015021-pol2qm74 4648 11 these these DT cord-015021-pol2qm74 4648 12 processes process NNS cord-015021-pol2qm74 4648 13 since since IN cord-015021-pol2qm74 4648 14 it -PRON- PRP cord-015021-pol2qm74 4648 15 eradicates eradicate VBZ cord-015021-pol2qm74 4648 16 the the DT cord-015021-pol2qm74 4648 17 influence influence NN cord-015021-pol2qm74 4648 18 of of IN cord-015021-pol2qm74 4648 19 infectious infectious JJ cord-015021-pol2qm74 4648 20 factc factc NN cord-015021-pol2qm74 4648 21 ~ ~ NFP cord-015021-pol2qm74 4648 22 rs rs NN cord-015021-pol2qm74 4648 23 . . . cord-015021-pol2qm74 4649 1 32 32 CD cord-015021-pol2qm74 4649 2 dogs~ dogs~ NNS cord-015021-pol2qm74 4649 3 in in IN cord-015021-pol2qm74 4649 4 whom whom WP cord-015021-pol2qm74 4649 5 MI MI NNP cord-015021-pol2qm74 4649 6 underwent undergo VBD cord-015021-pol2qm74 4649 7 different different JJ cord-015021-pol2qm74 4649 8 forms form NNS cord-015021-pol2qm74 4649 9 o¢ o¢ NNP cord-015021-pol2qm74 4649 10 healer healer NN cord-015021-pol2qm74 4649 11 , , , cord-015021-pol2qm74 4649 12 g g NN cord-015021-pol2qm74 4649 13 ; ; : cord-015021-pol2qm74 4649 14 bhn~ bhn~ NNP cord-015021-pol2qm74 4650 1 ed ed NNP cord-015021-pol2qm74 4651 1 ~h ~h NFP cord-015021-pol2qm74 4651 2 ~ ~ NFP cord-015021-pol2qm74 4651 3 t t XX cord-015021-pol2qm74 4651 4 during during IN cord-015021-pol2qm74 4651 5 the the DT cord-015021-pol2qm74 4651 6 acute acute JJ cord-015021-pol2qm74 4651 7 phase phase NN cord-015021-pol2qm74 4651 8 of of IN cord-015021-pol2qm74 4651 9 the the DT cord-015021-pol2qm74 4651 10 disease disease NN cord-015021-pol2qm74 4651 11 there there EX cord-015021-pol2qm74 4651 12 was be VBD cord-015021-pol2qm74 4651 13 a a DT cord-015021-pol2qm74 4651 14 characteristic characteristic JJ cord-015021-pol2qm74 4651 15 rise rise NN cord-015021-pol2qm74 4651 16 of of IN cord-015021-pol2qm74 4651 17 ne!~ropeptides ne!~ropeptide NNS cord-015021-pol2qm74 4651 18 in in IN cord-015021-pol2qm74 4651 19 the the DT cord-015021-pol2qm74 4651 20 blood blood NN cord-015021-pol2qm74 4651 21 . . . cord-015021-pol2qm74 4652 1 These these DT cord-015021-pol2qm74 4652 2 neuropeptides neuropeptide NNS cord-015021-pol2qm74 4652 3 had have VBD cord-015021-pol2qm74 4652 4 nociceptive nociceptive JJ cord-015021-pol2qm74 4652 5 and and CC cord-015021-pol2qm74 4652 6 antinociceptive antinociceptive JJ cord-015021-pol2qm74 4652 7 effects effect NNS cord-015021-pol2qm74 4652 8 . . . cord-015021-pol2qm74 4653 1 Particularly particularly RB cord-015021-pol2qm74 4653 2 substance substance NN cord-015021-pol2qm74 4653 3 P p NN cord-015021-pol2qm74 4653 4 and and CC cord-015021-pol2qm74 4653 5 -endorphins -endorphin NNS cord-015021-pol2qm74 4653 6 triggered trigger VBD cord-015021-pol2qm74 4653 7 off off RP cord-015021-pol2qm74 4653 8 the the DT cord-015021-pol2qm74 4653 9 development development NN cord-015021-pol2qm74 4653 10 of of IN cord-015021-pol2qm74 4653 11 compensatory compensatory JJ cord-015021-pol2qm74 4653 12 and and CC cord-015021-pol2qm74 4653 13 adaptive adaptive JJ cord-015021-pol2qm74 4653 14 mechanisms mechanism NNS cord-015021-pol2qm74 4653 15 and and CC cord-015021-pol2qm74 4653 16 defined define VBD cord-015021-pol2qm74 4653 17 the the DT cord-015021-pol2qm74 4653 18 intensity intensity NN cord-015021-pol2qm74 4653 19 of of IN cord-015021-pol2qm74 4653 20 inflammatory inflammatory JJ cord-015021-pol2qm74 4653 21 reaction reaction NN cord-015021-pol2qm74 4653 22 at at IN cord-015021-pol2qm74 4653 23 the the DT cord-015021-pol2qm74 4653 24 zone zone NN cord-015021-pol2qm74 4653 25 of of IN cord-015021-pol2qm74 4653 26 ischem ischem NNP cord-015021-pol2qm74 4654 1 ~t ~t JJ cord-015021-pol2qm74 4654 2 : : : cord-015021-pol2qm74 4654 3 damage damage NN cord-015021-pol2qm74 4654 4 - - HYPH cord-015021-pol2qm74 4654 5 Notable notable JJ cord-015021-pol2qm74 4654 6 fall fall NN cord-015021-pol2qm74 4654 7 in in IN cord-015021-pol2qm74 4654 8 substance substance NN cord-015021-pol2qm74 4654 9 P p NN cord-015021-pol2qm74 4654 10 levels level NNS cord-015021-pol2qm74 4654 11 after after IN cord-015021-pol2qm74 4654 12 an an DT cord-015021-pol2qm74 4654 13 ~nitial ~nitial CD cord-015021-pol2qm74 4654 14 increase increase NN cord-015021-pol2qm74 4654 15 , , , cord-015021-pol2qm74 4654 16 while while IN cord-015021-pol2qm74 4654 17 The the DT cord-015021-pol2qm74 4654 18 ~-endorphins ~-endorphin NNS cord-015021-pol2qm74 4654 19 stayed stay VBD cord-015021-pol2qm74 4654 20 high high JJ cord-015021-pol2qm74 4654 21 was be VBD cord-015021-pol2qm74 4654 22 an an DT cord-015021-pol2qm74 4654 23 important important JJ cord-015021-pol2qm74 4654 24 condition condition NN cord-015021-pol2qm74 4654 25 for for IN cord-015021-pol2qm74 4654 26 non non JJ cord-015021-pol2qm74 4654 27 complicated complicated JJ cord-015021-pol2qm74 4654 28 healing healing NN cord-015021-pol2qm74 4654 29 of of IN cord-015021-pol2qm74 4654 30 MI MI NNP cord-015021-pol2qm74 4654 31 . . . cord-015021-pol2qm74 4655 1 On on IN cord-015021-pol2qm74 4655 2 the the DT cord-015021-pol2qm74 4655 3 other other JJ cord-015021-pol2qm74 4655 4 hand hand NN cord-015021-pol2qm74 4655 5 high high JJ cord-015021-pol2qm74 4655 6 levels level NNS cord-015021-pol2qm74 4655 7 of of IN cord-015021-pol2qm74 4655 8 substance substance NN cord-015021-pol2qm74 4655 9 P p NN cord-015021-pol2qm74 4655 10 with with IN cord-015021-pol2qm74 4655 11 low low JJ cord-015021-pol2qm74 4655 12 ~-endorphin ~-endorphin NFP cord-015021-pol2qm74 4655 13 concentrations concentration NNS cord-015021-pol2qm74 4655 14 lead lead VBP cord-015021-pol2qm74 4655 15 to to IN cord-015021-pol2qm74 4655 16 increased increase VBN cord-015021-pol2qm74 4655 17 infiltration infiltration NN cord-015021-pol2qm74 4655 18 o~ o~ CD cord-015021-pol2qm74 4655 19 neutrophils neutrophil NNS cord-015021-pol2qm74 4655 20 into into IN cord-015021-pol2qm74 4655 21 the the DT cord-015021-pol2qm74 4655 22 infarction infarction NN cord-015021-pol2qm74 4655 23 zone zone NN cord-015021-pol2qm74 4655 24 and and CC cord-015021-pol2qm74 4655 25 weakened weaken VBD cord-015021-pol2qm74 4655 26 the the DT cord-015021-pol2qm74 4655 27 activity activity NN cord-015021-pol2qm74 4655 28 of of IN cord-015021-pol2qm74 4655 29 synthetic synthetic JJ cord-015021-pol2qm74 4655 30 processes~ processes~ NN cord-015021-pol2qm74 4655 31 thereby thereby RB cord-015021-pol2qm74 4655 32 leading lead VBG cord-015021-pol2qm74 4655 33 to to IN cord-015021-pol2qm74 4655 34 left leave VBN cord-015021-pol2qm74 4655 35 ventricular ventricular JJ cord-015021-pol2qm74 4655 36 aneurysm aneurysm NN cord-015021-pol2qm74 4655 37 . . . cord-015021-pol2qm74 4656 1 At at IN cord-015021-pol2qm74 4656 2 the the DT cord-015021-pol2qm74 4656 3 same same JJ cord-015021-pol2qm74 4656 4 time time NN cord-015021-pol2qm74 4656 5 low low JJ cord-015021-pol2qm74 4656 6 intitial intitial JJ cord-015021-pol2qm74 4656 7 levels level NNS cord-015021-pol2qm74 4656 8 of of IN cord-015021-pol2qm74 4656 9 substance substance NN cord-015021-pol2qm74 4656 10 P p NN cord-015021-pol2qm74 4656 11 slowed slow VBD cord-015021-pol2qm74 4656 12 down down IN cord-015021-pol2qm74 4656 13 the the DT cord-015021-pol2qm74 4656 14 development development NN cord-015021-pol2qm74 4656 15 of of IN cord-015021-pol2qm74 4656 16 necrotic necrotic JJ cord-015021-pol2qm74 4656 17 processes process NNS cord-015021-pol2qm74 4656 18 which which WDT cord-015021-pol2qm74 4656 19 lead lead VBP cord-015021-pol2qm74 4656 20 to to TO cord-015021-pol2qm74 4656 21 delay delay VB cord-015021-pol2qm74 4656 22 in in IN cord-015021-pol2qm74 4656 23 refunctioning refunctioning NN cord-015021-pol2qm74 4656 24 of of IN cord-015021-pol2qm74 4656 25 the the DT cord-015021-pol2qm74 4656 26 heart heart NN cord-015021-pol2qm74 4656 27 and and CC cord-015021-pol2qm74 4656 28 complicated complicate VBD cord-015021-pol2qm74 4656 29 the the DT cord-015021-pol2qm74 4656 30 healing healing NN cord-015021-pol2qm74 4656 31 process process NN cord-015021-pol2qm74 4656 32 . . . cord-015021-pol2qm74 4657 1 Thus thus RB cord-015021-pol2qm74 4657 2 , , , cord-015021-pol2qm74 4657 3 regulation regulation NN cord-015021-pol2qm74 4657 4 of of IN cord-015021-pol2qm74 4657 5 the the DT cord-015021-pol2qm74 4657 6 levels level NNS cord-015021-pol2qm74 4657 7 of of IN cord-015021-pol2qm74 4657 8 neuropeptides neuropeptide NNS cord-015021-pol2qm74 4657 9 in in IN cord-015021-pol2qm74 4657 10 the the DT cord-015021-pol2qm74 4657 11 blood blood NN cord-015021-pol2qm74 4657 12 in in IN cord-015021-pol2qm74 4657 13 trauma trauma NN cord-015021-pol2qm74 4657 14 forms form VBZ cord-015021-pol2qm74 4657 15 a a DT cord-015021-pol2qm74 4657 16 perspective perspective NN cord-015021-pol2qm74 4657 17 method method NN cord-015021-pol2qm74 4657 18 of of IN cord-015021-pol2qm74 4657 19 its -PRON- PRP$ cord-015021-pol2qm74 4657 20 treatment treatment NN cord-015021-pol2qm74 4657 21 . . . cord-015021-pol2qm74 4658 1 OF of IN cord-015021-pol2qm74 4658 2 LAPARASCOPIC LAPARASCOPIC NNP cord-015021-pol2qm74 4659 1 VERSUS versu NNS cord-015021-pol2qm74 4659 2 OPEN open JJ cord-015021-pol2qm74 4659 3 CHOLEOCYSTECTOMY CHOLEOCYSTECTOMY NNP cord-015021-pol2qm74 4659 4 C. C. NNP cord-015021-pol2qm74 4659 5 Schinkel Schinkel NNP cord-015021-pol2qm74 4659 6 , , , cord-015021-pol2qm74 4659 7 S. S. NNP cord-015021-pol2qm74 4659 8 Zimmer Zimmer NNP cord-015021-pol2qm74 4659 9 , , , cord-015021-pol2qm74 4659 10 V. V. NNP cord-015021-pol2qm74 4659 11 Lange Lange NNP cord-015021-pol2qm74 4659 12 , , , cord-015021-pol2qm74 4659 13 D. D. NNP cord-015021-pol2qm74 4659 14 Fuchs Fuchs NNP cord-015021-pol2qm74 4659 15 , , , cord-015021-pol2qm74 4659 16 E. E. NNP cord-015021-pol2qm74 4659 17 Faist Faist NNP cord-015021-pol2qm74 4660 1 The the DT cord-015021-pol2qm74 4660 2 impairment impairment NN cord-015021-pol2qm74 4660 3 of of IN cord-015021-pol2qm74 4660 4 immune immune JJ cord-015021-pol2qm74 4660 5 function function NN cord-015021-pol2qm74 4660 6 due due IN cord-015021-pol2qm74 4660 7 to to IN cord-015021-pol2qm74 4660 8 surgical surgical JJ cord-015021-pol2qm74 4660 9 trauma trauma NN cord-015021-pol2qm74 4660 10 may may MD cord-015021-pol2qm74 4660 11 be be VB cord-015021-pol2qm74 4660 12 followed follow VBN cord-015021-pol2qm74 4660 13 by by IN cord-015021-pol2qm74 4660 14 deleterious deleterious JJ cord-015021-pol2qm74 4660 15 septic septic JJ cord-015021-pol2qm74 4660 16 sequelae sequela NNS cord-015021-pol2qm74 4660 17 . . . cord-015021-pol2qm74 4661 1 Compared compare VBN cord-015021-pol2qm74 4661 2 to to TO cord-015021-pol2qm74 4661 3 open open VB cord-015021-pol2qm74 4661 4 abdominal abdominal JJ cord-015021-pol2qm74 4661 5 surgical surgical JJ cord-015021-pol2qm74 4661 6 procedures procedure NNS cord-015021-pol2qm74 4661 7 ( ( -LRB- cord-015021-pol2qm74 4661 8 LAP LAP NNP cord-015021-pol2qm74 4661 9 ) ) -RRB- cord-015021-pol2qm74 4661 10 , , , cord-015021-pol2qm74 4661 11 laparaseopic laparaseopic NNP cord-015021-pol2qm74 4661 12 surgery surgery NN cord-015021-pol2qm74 4661 13 ( ( -LRB- cord-015021-pol2qm74 4661 14 LSC LSC NNP cord-015021-pol2qm74 4661 15 ) ) -RRB- cord-015021-pol2qm74 4661 16 is be VBZ cord-015021-pol2qm74 4661 17 associated associate VBN cord-015021-pol2qm74 4661 18 with with IN cord-015021-pol2qm74 4661 19 a a DT cord-015021-pol2qm74 4661 20 decrease decrease NN cord-015021-pol2qm74 4661 21 in in IN cord-015021-pol2qm74 4661 22 hospital hospital NN cord-015021-pol2qm74 4661 23 stay stay NN cord-015021-pol2qm74 4661 24 and and CC cord-015021-pol2qm74 4661 25 in in IN cord-015021-pol2qm74 4661 26 accelerated accelerated JJ cord-015021-pol2qm74 4661 27 patient patient NN cord-015021-pol2qm74 4661 28 recover recover VBP cord-015021-pol2qm74 4661 29 . . . cord-015021-pol2qm74 4662 1 The the DT cord-015021-pol2qm74 4662 2 aim aim NN cord-015021-pol2qm74 4662 3 of of IN cord-015021-pol2qm74 4662 4 the the DT cord-015021-pol2qm74 4662 5 study study NN cord-015021-pol2qm74 4662 6 was be VBD cord-015021-pol2qm74 4662 7 to to TO cord-015021-pol2qm74 4662 8 evaluate evaluate VB cord-015021-pol2qm74 4662 9 the the DT cord-015021-pol2qm74 4662 10 sensitivity sensitivity NN cord-015021-pol2qm74 4662 11 of of IN cord-015021-pol2qm74 4662 12 the the DT cord-015021-pol2qm74 4662 13 immune immune JJ cord-015021-pol2qm74 4662 14 sermn sermn NN cord-015021-pol2qm74 4662 15 parameters parameter NNS cord-015021-pol2qm74 4662 16 of of IN cord-015021-pol2qm74 4662 17 IL-6 IL-6 NNP cord-015021-pol2qm74 4662 18 , , , cord-015021-pol2qm74 4662 19 SAA SAA NNP cord-015021-pol2qm74 4662 20 and and CC cord-015021-pol2qm74 4662 21 neopterin neopterin NNP cord-015021-pol2qm74 4662 22 , , , cord-015021-pol2qm74 4662 23 the the DT cord-015021-pol2qm74 4662 24 percentage percentage NN cord-015021-pol2qm74 4662 25 of of IN cord-015021-pol2qm74 4662 26 CD14 CD14 NNP cord-015021-pol2qm74 4662 27 + + CC cord-015021-pol2qm74 4662 28 cells cell NNS cord-015021-pol2qm74 4662 29 , , , cord-015021-pol2qm74 4662 30 the the DT cord-015021-pol2qm74 4662 31 in in IN cord-015021-pol2qm74 4662 32 - - HYPH cord-015021-pol2qm74 4662 33 vitro vitro FW cord-015021-pol2qm74 4662 34 IL-2 il-2 NN cord-015021-pol2qm74 4662 35 synthesis synthesis NN cord-015021-pol2qm74 4662 36 after after IN cord-015021-pol2qm74 4662 37 mitogen mitogen NN cord-015021-pol2qm74 4662 38 stimulation stimulation NN cord-015021-pol2qm74 4662 39 and and CC cord-015021-pol2qm74 4662 40 lymphocyte lymphocyte NN cord-015021-pol2qm74 4662 41 proliferation proliferation NN cord-015021-pol2qm74 4662 42 , , , cord-015021-pol2qm74 4662 43 in in IN cord-015021-pol2qm74 4662 44 order order NN cord-015021-pol2qm74 4662 45 to to TO cord-015021-pol2qm74 4662 46 purposefully purposefully RB cord-015021-pol2qm74 4662 47 discriminate discriminate VB cord-015021-pol2qm74 4662 48 differences difference NNS cord-015021-pol2qm74 4662 49 in in IN cord-015021-pol2qm74 4662 50 the the DT cord-015021-pol2qm74 4662 51 severity severity NN cord-015021-pol2qm74 4662 52 of of IN cord-015021-pol2qm74 4662 53 trauma trauma NN cord-015021-pol2qm74 4662 54 . . . cord-015021-pol2qm74 4663 1 We -PRON- PRP cord-015021-pol2qm74 4663 2 investigated investigate VBD cord-015021-pol2qm74 4663 3 the the DT cord-015021-pol2qm74 4663 4 blood blood NN cord-015021-pol2qm74 4663 5 of of IN cord-015021-pol2qm74 4663 6 27 27 CD cord-015021-pol2qm74 4663 7 patients patient NNS cord-015021-pol2qm74 4663 8 with with IN cord-015021-pol2qm74 4663 9 cholecystolithiasis cholecystolithiasis NN cord-015021-pol2qm74 4663 10 undergoing undergo VBG cord-015021-pol2qm74 4663 11 either either CC cord-015021-pol2qm74 4663 12 laparascopic laparascopic NNP cord-015021-pol2qm74 4663 13 ( ( -LRB- cord-015021-pol2qm74 4663 14 16 16 CD cord-015021-pol2qm74 4663 15 ) ) -RRB- cord-015021-pol2qm74 4663 16 or or CC cord-015021-pol2qm74 4663 17 open open JJ cord-015021-pol2qm74 4663 18 ( ( -LRB- cord-015021-pol2qm74 4663 19 I i NN cord-015021-pol2qm74 4663 20 1 1 CD cord-015021-pol2qm74 4663 21 ) ) -RRB- cord-015021-pol2qm74 4664 1 cholecystectomy cholecystectomy NN cord-015021-pol2qm74 4664 2 on on IN cord-015021-pol2qm74 4664 3 consecutive consecutive JJ cord-015021-pol2qm74 4664 4 perioperative perioperative JJ cord-015021-pol2qm74 4664 5 days day NNS cord-015021-pol2qm74 4664 6 -1 -1 JJ cord-015021-pol2qm74 4664 7 , , , cord-015021-pol2qm74 4664 8 1 1 CD cord-015021-pol2qm74 4664 9 , , , cord-015021-pol2qm74 4664 10 2 2 CD cord-015021-pol2qm74 4664 11 and and CC cord-015021-pol2qm74 4664 12 3 3 CD cord-015021-pol2qm74 4664 13 . . . cord-015021-pol2qm74 4665 1 There there EX cord-015021-pol2qm74 4665 2 was be VBD cord-015021-pol2qm74 4665 3 no no DT cord-015021-pol2qm74 4665 4 significant significant JJ cord-015021-pol2qm74 4665 5 difference difference NN cord-015021-pol2qm74 4665 6 between between IN cord-015021-pol2qm74 4665 7 the the DT cord-015021-pol2qm74 4665 8 two two CD cord-015021-pol2qm74 4665 9 groups group NNS cord-015021-pol2qm74 4665 10 concerning concern VBG cord-015021-pol2qm74 4665 11 age age NN cord-015021-pol2qm74 4665 12 and and CC cord-015021-pol2qm74 4665 13 sex sex NN cord-015021-pol2qm74 4665 14 . . . cord-015021-pol2qm74 4666 1 Patients patient NNS cord-015021-pol2qm74 4666 2 with with IN cord-015021-pol2qm74 4666 3 clinical clinical JJ cord-015021-pol2qm74 4666 4 signs sign NNS cord-015021-pol2qm74 4666 5 of of IN cord-015021-pol2qm74 4666 6 acute acute JJ cord-015021-pol2qm74 4666 7 cholecystitis cholecystitis NN cord-015021-pol2qm74 4666 8 were be VBD cord-015021-pol2qm74 4666 9 excluded exclude VBN cord-015021-pol2qm74 4666 10 from from IN cord-015021-pol2qm74 4666 11 the the DT cord-015021-pol2qm74 4666 12 study study NN cord-015021-pol2qm74 4666 13 . . . cord-015021-pol2qm74 4667 1 Operation operation NN cord-015021-pol2qm74 4667 2 time time NN cord-015021-pol2qm74 4667 3 and and CC cord-015021-pol2qm74 4667 4 hospital hospital NN cord-015021-pol2qm74 4667 5 stay stay NN cord-015021-pol2qm74 4667 6 were be VBD cord-015021-pol2qm74 4667 7 obviously obviously RB cord-015021-pol2qm74 4667 8 longer long JJR cord-015021-pol2qm74 4667 9 in in IN cord-015021-pol2qm74 4667 10 LAP lap NN cord-015021-pol2qm74 4667 11 patients patient NNS cord-015021-pol2qm74 4667 12 ( ( -LRB- cord-015021-pol2qm74 4667 13 67 67 CD cord-015021-pol2qm74 4667 14 versus versus IN cord-015021-pol2qm74 4667 15 145 145 CD cord-015021-pol2qm74 4667 16 minutes minute NNS cord-015021-pol2qm74 4667 17 , , , cord-015021-pol2qm74 4667 18 5 5 CD cord-015021-pol2qm74 4667 19 versus versus IN cord-015021-pol2qm74 4667 20 20 20 CD cord-015021-pol2qm74 4667 21 days day NNS cord-015021-pol2qm74 4667 22 ) ) -RRB- cord-015021-pol2qm74 4667 23 compared compare VBN cord-015021-pol2qm74 4667 24 to to IN cord-015021-pol2qm74 4667 25 the the DT cord-015021-pol2qm74 4667 26 LSC LSC NNP cord-015021-pol2qm74 4667 27 group group NN cord-015021-pol2qm74 4667 28 . . . cord-015021-pol2qm74 4668 1 Concerning concern VBG cord-015021-pol2qm74 4668 2 the the DT cord-015021-pol2qm74 4668 3 unspecific unspecific JJ cord-015021-pol2qm74 4668 4 acute acute JJ cord-015021-pol2qm74 4668 5 phase phase NN cord-015021-pol2qm74 4668 6 reaction reaction NN cord-015021-pol2qm74 4668 7 we -PRON- PRP cord-015021-pol2qm74 4668 8 could could MD cord-015021-pol2qm74 4668 9 show show VB cord-015021-pol2qm74 4668 10 no no DT cord-015021-pol2qm74 4668 11 difference difference NN cord-015021-pol2qm74 4668 12 in in IN cord-015021-pol2qm74 4668 13 the the DT cord-015021-pol2qm74 4668 14 increment increment NN cord-015021-pol2qm74 4668 15 of of IN cord-015021-pol2qm74 4668 16 senun senun NNS cord-015021-pol2qm74 4668 17 amyoid amyoid NNP cord-015021-pol2qm74 4668 18 A A NNP cord-015021-pol2qm74 4668 19 ( ( -LRB- cord-015021-pol2qm74 4668 20 SAA SAA NNP cord-015021-pol2qm74 4668 21 ) ) -RRB- cord-015021-pol2qm74 4668 22 synthesis synthesis NN cord-015021-pol2qm74 4668 23 in in IN cord-015021-pol2qm74 4668 24 the the DT cord-015021-pol2qm74 4668 25 LSC LSC NNP cord-015021-pol2qm74 4668 26 group group NN cord-015021-pol2qm74 4668 27 ( ( -LRB- cord-015021-pol2qm74 4668 28 D- d- XX cord-015021-pol2qm74 4669 1 I -PRON- PRP cord-015021-pol2qm74 4669 2 40 40 CD cord-015021-pol2qm74 4669 3 + + SYM cord-015021-pol2qm74 4669 4 1 1 CD cord-015021-pol2qm74 4669 5 lng lng NN cord-015021-pol2qm74 4669 6 / / SYM cord-015021-pol2qm74 4669 7 ml ml NNP cord-015021-pol2qm74 4669 8 , , , cord-015021-pol2qm74 4669 9 D1 D1 NNP cord-015021-pol2qm74 4669 10 362 362 CD cord-015021-pol2qm74 4669 11 + + SYM cord-015021-pol2qm74 4669 12 43ng 43ng NN cord-015021-pol2qm74 4669 13 / / SYM cord-015021-pol2qm74 4669 14 ml ml NN cord-015021-pol2qm74 4669 15 ) ) -RRB- cord-015021-pol2qm74 4669 16 versus versus IN cord-015021-pol2qm74 4669 17 LAP lap NN cord-015021-pol2qm74 4669 18 group group NN cord-015021-pol2qm74 4669 19 ( ( -LRB- cord-015021-pol2qm74 4670 1 D-1 D-1 NNP cord-015021-pol2qm74 4670 2 61 61 CD cord-015021-pol2qm74 4670 3 + + SYM cord-015021-pol2qm74 4670 4 19ng 19ng NN cord-015021-pol2qm74 4670 5 / / SYM cord-015021-pol2qm74 4670 6 ml ml NN cord-015021-pol2qm74 4670 7 , , , cord-015021-pol2qm74 4670 8 D1 D1 NNP cord-015021-pol2qm74 4670 9 457 457 CD cord-015021-pol2qm74 4670 10 + + SYM cord-015021-pol2qm74 4670 11 45ng 45ng NN cord-015021-pol2qm74 4670 12 / / SYM cord-015021-pol2qm74 4670 13 ml ml NN cord-015021-pol2qm74 4670 14 ) ) -RRB- cord-015021-pol2qm74 4670 15 , , . cord-015021-pol2qm74 4671 1 while while IN cord-015021-pol2qm74 4671 2 in in IN cord-015021-pol2qm74 4671 3 serum serum NN cord-015021-pol2qm74 4671 4 IL-6 IL-6 NNP cord-015021-pol2qm74 4671 5 levels level NNS cord-015021-pol2qm74 4671 6 we -PRON- PRP cord-015021-pol2qm74 4671 7 saw see VBD cord-015021-pol2qm74 4671 8 a a DT cord-015021-pol2qm74 4671 9 less less RBR cord-015021-pol2qm74 4671 10 steep steep JJ cord-015021-pol2qm74 4671 11 increment increment NN cord-015021-pol2qm74 4671 12 in in IN cord-015021-pol2qm74 4671 13 the the DT cord-015021-pol2qm74 4671 14 LSC LSC NNP cord-015021-pol2qm74 4671 15 group group NN cord-015021-pol2qm74 4671 16 ( ( -LRB- cord-015021-pol2qm74 4671 17 7-fold 7-fold CD cord-015021-pol2qm74 4671 18 from from IN cord-015021-pol2qm74 4671 19 D-1 D-1 NNP cord-015021-pol2qm74 4671 20 to to IN cord-015021-pol2qm74 4671 21 D d NN cord-015021-pol2qm74 4671 22 1 1 CD cord-015021-pol2qm74 4671 23 ) ) -RRB- cord-015021-pol2qm74 4671 24 compared compare VBN cord-015021-pol2qm74 4671 25 to to IN cord-015021-pol2qm74 4671 26 the the DT cord-015021-pol2qm74 4671 27 LAP LAP NNP cord-015021-pol2qm74 4671 28 group group NN cord-015021-pol2qm74 4671 29 ( ( -LRB- cord-015021-pol2qm74 4671 30 10-fold 10-fold JJ cord-015021-pol2qm74 4671 31 from from IN cord-015021-pol2qm74 4671 32 D-1 D-1 NNP cord-015021-pol2qm74 4671 33 to to IN cord-015021-pol2qm74 4671 34 D d NN cord-015021-pol2qm74 4671 35 1 1 CD cord-015021-pol2qm74 4671 36 ) ) -RRB- cord-015021-pol2qm74 4671 37 . . . cord-015021-pol2qm74 4672 1 The the DT cord-015021-pol2qm74 4672 2 analysis analysis NN cord-015021-pol2qm74 4672 3 of of IN cord-015021-pol2qm74 4672 4 CD14 CD14 NNP cord-015021-pol2qm74 4672 5 + + CC cord-015021-pol2qm74 4672 6 receptor receptor NN cord-015021-pol2qm74 4672 7 expression expression NN cord-015021-pol2qm74 4672 8 and and CC cord-015021-pol2qm74 4672 9 serum serum NN cord-015021-pol2qm74 4672 10 neopterin neopterin NNP cord-015021-pol2qm74 4672 11 did do VBD cord-015021-pol2qm74 4672 12 not not RB cord-015021-pol2qm74 4672 13 reveal reveal VB cord-015021-pol2qm74 4672 14 any any DT cord-015021-pol2qm74 4672 15 difference difference NN cord-015021-pol2qm74 4672 16 between between IN cord-015021-pol2qm74 4672 17 the the DT cord-015021-pol2qm74 4672 18 groups group NNS cord-015021-pol2qm74 4672 19 . . . cord-015021-pol2qm74 4673 1 Lymphocyte lymphocyte NN cord-015021-pol2qm74 4673 2 function function NN cord-015021-pol2qm74 4673 3 showed show VBD cord-015021-pol2qm74 4673 4 an an DT cord-015021-pol2qm74 4673 5 impairment impairment NN cord-015021-pol2qm74 4673 6 of of IN cord-015021-pol2qm74 4673 7 proliferation proliferation NN cord-015021-pol2qm74 4673 8 to to IN cord-015021-pol2qm74 4673 9 antigen antigen NN cord-015021-pol2qm74 4673 10 stimulation stimulation NN cord-015021-pol2qm74 4673 11 in in IN cord-015021-pol2qm74 4673 12 LAP lap NN cord-015021-pol2qm74 4673 13 ( ( -LRB- cord-015021-pol2qm74 4673 14 D D NNP cord-015021-pol2qm74 4673 15 -1:24.000 -1:24.000 NNP cord-015021-pol2qm74 4673 16 + + SYM cord-015021-pol2qm74 4673 17 3.330 3.330 CD cord-015021-pol2qm74 4673 18 cpm cpm NNP cord-015021-pol2qm74 4673 19 , , , cord-015021-pol2qm74 4673 20 D D NNP cord-015021-pol2qm74 4673 21 1:17.300 1:17.300 CD cord-015021-pol2qm74 4673 22 + + SYM cord-015021-pol2qm74 4673 23 3.000 3.000 CD cord-015021-pol2qm74 4673 24 cpm cpm NN cord-015021-pol2qm74 4673 25 ) ) -RRB- cord-015021-pol2qm74 4673 26 compared compare VBN cord-015021-pol2qm74 4673 27 to to IN cord-015021-pol2qm74 4673 28 the the DT cord-015021-pol2qm74 4673 29 LSC LSC NNP cord-015021-pol2qm74 4673 30 group group NN cord-015021-pol2qm74 4673 31 ( ( -LRB- cord-015021-pol2qm74 4673 32 D D NNP cord-015021-pol2qm74 4673 33 -h -h NNP cord-015021-pol2qm74 4673 34 22.500 22.500 CD cord-015021-pol2qm74 4673 35 + + SYM cord-015021-pol2qm74 4673 36 4.200 4.200 CD cord-015021-pol2qm74 4673 37 cpm cpm NN cord-015021-pol2qm74 4673 38 , , , cord-015021-pol2qm74 4673 39 D D NNP cord-015021-pol2qm74 4673 40 h h NN cord-015021-pol2qm74 4673 41 26.000 26.000 CD cord-015021-pol2qm74 4673 42 + + SYM cord-015021-pol2qm74 4673 43 2.900 2.900 CD cord-015021-pol2qm74 4673 44 cpm cpm NNP cord-015021-pol2qm74 4673 45 ) ) -RRB- cord-015021-pol2qm74 4673 46 . . . cord-015021-pol2qm74 4674 1 In in IN cord-015021-pol2qm74 4674 2 both both DT cord-015021-pol2qm74 4674 3 groups group NNS cord-015021-pol2qm74 4674 4 IL-2 IL-2 NNP cord-015021-pol2qm74 4674 5 synthesis synthesis NN cord-015021-pol2qm74 4674 6 was be VBD cord-015021-pol2qm74 4674 7 decreased decrease VBN cord-015021-pol2qm74 4674 8 post post RB cord-015021-pol2qm74 4674 9 - - JJ cord-015021-pol2qm74 4674 10 operatively operatively RB cord-015021-pol2qm74 4674 11 . . . cord-015021-pol2qm74 4675 1 Our -PRON- PRP$ cord-015021-pol2qm74 4675 2 data datum NNS cord-015021-pol2qm74 4675 3 indicate indicate VBP cord-015021-pol2qm74 4675 4 that that IN cord-015021-pol2qm74 4675 5 laparascopic laparascopic NNP cord-015021-pol2qm74 4675 6 cholecystectomy cholecystectomy NN cord-015021-pol2qm74 4675 7 reusults reusults NNP cord-015021-pol2qm74 4675 8 in in IN cord-015021-pol2qm74 4675 9 a a DT cord-015021-pol2qm74 4675 10 less less RBR cord-015021-pol2qm74 4675 11 distinct distinct JJ cord-015021-pol2qm74 4675 12 unspecific unspecific JJ cord-015021-pol2qm74 4675 13 acute acute JJ cord-015021-pol2qm74 4675 14 phase phase NN cord-015021-pol2qm74 4675 15 reaction reaction NN cord-015021-pol2qm74 4675 16 post post NN cord-015021-pol2qm74 4675 17 - - NN cord-015021-pol2qm74 4675 18 trauma trauma NN cord-015021-pol2qm74 4675 19 compared compare VBN cord-015021-pol2qm74 4675 20 to to IN cord-015021-pol2qm74 4675 21 that that DT cord-015021-pol2qm74 4675 22 following follow VBG cord-015021-pol2qm74 4675 23 LAP lap NN cord-015021-pol2qm74 4675 24 . . . cord-015021-pol2qm74 4676 1 Neopterin neopterin JJ cord-015021-pol2qm74 4676 2 serum serum NN cord-015021-pol2qm74 4676 3 levels level NNS cord-015021-pol2qm74 4676 4 and and CC cord-015021-pol2qm74 4676 5 CD14 CD14 NNP cord-015021-pol2qm74 4676 6 receptor receptor NN cord-015021-pol2qm74 4676 7 expression expression NN cord-015021-pol2qm74 4676 8 show show VBP cord-015021-pol2qm74 4676 9 that that IN cord-015021-pol2qm74 4676 10 these these DT cord-015021-pol2qm74 4676 11 parameters parameter NNS cord-015021-pol2qm74 4676 12 apparently apparently RB cord-015021-pol2qm74 4676 13 are be VBP cord-015021-pol2qm74 4676 14 less less RBR cord-015021-pol2qm74 4676 15 useful useful JJ cord-015021-pol2qm74 4676 16 markers marker NNS cord-015021-pol2qm74 4676 17 to to TO cord-015021-pol2qm74 4676 18 detect detect VB cord-015021-pol2qm74 4676 19 differences difference NNS cord-015021-pol2qm74 4676 20 of of IN cord-015021-pol2qm74 4676 21 surgical surgical JJ cord-015021-pol2qm74 4676 22 trauma trauma NN cord-015021-pol2qm74 4676 23 severity severity NN cord-015021-pol2qm74 4676 24 while while IN cord-015021-pol2qm74 4676 25 it -PRON- PRP cord-015021-pol2qm74 4676 26 appears appear VBZ cord-015021-pol2qm74 4676 27 that that IN cord-015021-pol2qm74 4676 28 the the DT cord-015021-pol2qm74 4676 29 impact impact NN cord-015021-pol2qm74 4676 30 of of IN cord-015021-pol2qm74 4676 31 LAP lap NN cord-015021-pol2qm74 4676 32 is be VBZ cord-015021-pol2qm74 4676 33 reflected reflect VBN cord-015021-pol2qm74 4676 34 most most RBS cord-015021-pol2qm74 4676 35 impressively impressively RB cord-015021-pol2qm74 4676 36 on on IN cord-015021-pol2qm74 4676 37 the the DT cord-015021-pol2qm74 4676 38 lymphocyte lymphocyte NN cord-015021-pol2qm74 4676 39 compartment compartment NN cord-015021-pol2qm74 4676 40 . . . cord-015021-pol2qm74 4676 41 _SP cord-015021-pol2qm74 4677 1 Trauma trauma NN cord-015021-pol2qm74 4677 2 alters alter VBZ cord-015021-pol2qm74 4677 3 the the DT cord-015021-pol2qm74 4677 4 host host NN cord-015021-pol2qm74 4677 5 resistance resistance NN cord-015021-pol2qm74 4677 6 of of IN cord-015021-pol2qm74 4677 7 organism organism NN cord-015021-pol2qm74 4677 8 and and CC cord-015021-pol2qm74 4677 9 is be VBZ cord-015021-pol2qm74 4677 10 accompained accompaine VBN cord-015021-pol2qm74 4677 11 by by IN cord-015021-pol2qm74 4677 12 appearence appearence NN cord-015021-pol2qm74 4677 13 of of IN cord-015021-pol2qm74 4677 14 excgenic excgenic NNP cord-015021-pol2qm74 4677 15 and and CC cord-015021-pol2qm74 4677 16 endogenic endogenic NNP cord-015021-pol2qm74 4677 17 proteins protein NNS cord-015021-pol2qm74 4677 18 in in IN cord-015021-pol2qm74 4677 19 the the DT cord-015021-pol2qm74 4677 20 body body NN cord-015021-pol2qm74 4677 21 . . . cord-015021-pol2qm74 4678 1 To to TO cord-015021-pol2qm74 4678 2 understand understand VB cord-015021-pol2qm74 4678 3 the the DT cord-015021-pol2qm74 4678 4 molecular molecular JJ cord-015021-pol2qm74 4678 5 mechanisms mechanism NNS cord-015021-pol2qm74 4678 6 of of IN cord-015021-pol2qm74 4678 7 host host NN cord-015021-pol2qm74 4678 8 resistans resistan NNS cord-015021-pol2qm74 4678 9 disorders disorder NNS cord-015021-pol2qm74 4678 10 in in IN cord-015021-pol2qm74 4678 11 trauma trauma NN cord-015021-pol2qm74 4678 12 , , , cord-015021-pol2qm74 4678 13 as as IN cord-015021-pol2qm74 4678 14 a a DT cord-015021-pol2qm74 4678 15 first first JJ cord-015021-pol2qm74 4678 16 step step NN cord-015021-pol2qm74 4678 17 , , , cord-015021-pol2qm74 4678 18 the the DT cord-015021-pol2qm74 4678 19 genetic genetic JJ cord-015021-pol2qm74 4678 20 regulatory regulatory JJ cord-015021-pol2qm74 4678 21 mechanisms mechanism NNS cord-015021-pol2qm74 4678 22 of of IN cord-015021-pol2qm74 4678 23 immune immune JJ cord-015021-pol2qm74 4678 24 response response NN cord-015021-pol2qm74 4678 25 after after IN cord-015021-pol2qm74 4678 26 antigen antigen NN cord-015021-pol2qm74 4678 27 injection injection NN cord-015021-pol2qm74 4678 28 has have VBZ cord-015021-pol2qm74 4678 29 been be VBN cord-015021-pol2qm74 4678 30 studed stud VBN cord-015021-pol2qm74 4678 31 . . . cord-015021-pol2qm74 4679 1 The the DT cord-015021-pol2qm74 4679 2 appearence appearence NN cord-015021-pol2qm74 4679 3 of of IN cord-015021-pol2qm74 4679 4 specific specific JJ cord-015021-pol2qm74 4679 5 protein protein NN cord-015021-pol2qm74 4679 6 factors factor NNS cord-015021-pol2qm74 4679 7 ( ( -LRB- cord-015021-pol2qm74 4679 8 13 13 CD cord-015021-pol2qm74 4679 9 - - SYM cord-015021-pol2qm74 4679 10 19 19 CD cord-015021-pol2qm74 4679 11 and and CC cord-015021-pol2qm74 4679 12 25 25 CD cord-015021-pol2qm74 4679 13 kDa kDa NNS cord-015021-pol2qm74 4679 14 ) ) -RRB- cord-015021-pol2qm74 4679 15 , , , cord-015021-pol2qm74 4679 16 in in IN cord-015021-pol2qm74 4679 17 the the DT cord-015021-pol2qm74 4679 18 nucleus nucleus NN cord-015021-pol2qm74 4679 19 of of IN cord-015021-pol2qm74 4679 20 rat rat NN cord-015021-pol2qm74 4679 21 splenic splenic NN cord-015021-pol2qm74 4679 22 and and CC cord-015021-pol2qm74 4679 23 brain brain NN cord-015021-pol2qm74 4679 24 cells cell NNS cord-015021-pol2qm74 4679 25 , , , cord-015021-pol2qm74 4679 26 accordingly accordingly RB cord-015021-pol2qm74 4679 27 , , , cord-015021-pol2qm74 4679 28 was be VBD cord-015021-pol2qm74 4679 29 shown show VBN cord-015021-pol2qm74 4679 30 after after IN cord-015021-pol2qm74 4679 31 immunization immunization NN cord-015021-pol2qm74 4679 32 with with IN cord-015021-pol2qm74 4679 33 sheep sheep NN cord-015021-pol2qm74 4679 34 erythrocytes erythrocyte NNS cord-015021-pol2qm74 4679 35 . . . cord-015021-pol2qm74 4680 1 The the DT cord-015021-pol2qm74 4680 2 stimulatory stimulatory JJ cord-015021-pol2qm74 4680 3 effect effect NN cord-015021-pol2qm74 4680 4 of of IN cord-015021-pol2qm74 4680 5 these these DT cord-015021-pol2qm74 4680 6 factors factor NNS cord-015021-pol2qm74 4680 7 on on IN cord-015021-pol2qm74 4680 8 the the DT cord-015021-pol2qm74 4680 9 IL-2 IL-2 NNP cord-015021-pol2qm74 4680 10 mRNA mRNA NNP cord-015021-pol2qm74 4680 11 and and CC cord-015021-pol2qm74 4680 12 IL-2 IL-2 NNP cord-015021-pol2qm74 4680 13 production production NN cord-015021-pol2qm74 4680 14 was be VBD cord-015021-pol2qm74 4680 15 detected detect VBN cord-015021-pol2qm74 4680 16 . . . cord-015021-pol2qm74 4681 1 The the DT cord-015021-pol2qm74 4681 2 nucleotide nucleotide JJ cord-015021-pol2qm74 4681 3 sequences sequence NNS cord-015021-pol2qm74 4681 4 of of IN cord-015021-pol2qm74 4681 5 the the DT cord-015021-pol2qm74 4681 6 human human JJ cord-015021-pol2qm74 4681 7 IL-2 IL-2 NNP cord-015021-pol2qm74 4681 8 gene gene NN cord-015021-pol2qm74 4681 9 regulatory regulatory JJ cord-015021-pol2qm74 4681 10 region region NN cord-015021-pol2qm74 4681 11 bounding bound VBG cord-015021-pol2qm74 4681 12 by by IN cord-015021-pol2qm74 4681 13 the the DT cord-015021-pol2qm74 4681 14 splenic splenic JJ cord-015021-pol2qm74 4681 15 nuclear nuclear JJ cord-015021-pol2qm74 4681 16 proteins protein NNS cord-015021-pol2qm74 4681 17 were be VBD cord-015021-pol2qm74 4681 18 determined determine VBN cord-015021-pol2qm74 4681 19 between between IN cord-015021-pol2qm74 4681 20 +39 +39 CD cord-015021-pol2qm74 4681 21 - - SYM cord-015021-pol2qm74 4681 22 141 141 CD cord-015021-pol2qm74 4681 23 b.p b.p NNS cord-015021-pol2qm74 4681 24 . . . cord-015021-pol2qm74 4682 1 The the DT cord-015021-pol2qm74 4682 2 IL-2 IL-2 NNP cord-015021-pol2qm74 4682 3 trans trans NNP cord-015021-pol2qm74 4682 4 - - NNS cord-015021-pol2qm74 4682 5 factors factor NNS cord-015021-pol2qm74 4682 6 shows show VBZ cord-015021-pol2qm74 4682 7 the the DT cord-015021-pol2qm74 4682 8 affinity affinity NN cord-015021-pol2qm74 4682 9 to to IN cord-015021-pol2qm74 4682 10 splenic splenic JJ cord-015021-pol2qm74 4682 11 and and CC cord-015021-pol2qm74 4682 12 thymic thymic JJ cord-015021-pol2qm74 4682 13 lymphocytes lymphocyte NNS cord-015021-pol2qm74 4682 14 in in IN cord-015021-pol2qm74 4682 15 vitro vitro FW cord-015021-pol2qm74 4682 16 . . . cord-015021-pol2qm74 4683 1 Thus thus RB cord-015021-pol2qm74 4683 2 , , , cord-015021-pol2qm74 4683 3 the the DT cord-015021-pol2qm74 4683 4 antigen antigen NN cord-015021-pol2qm74 4683 5 causes cause VBZ cord-015021-pol2qm74 4683 6 the the DT cord-015021-pol2qm74 4683 7 appearence appearence NN cord-015021-pol2qm74 4683 8 of of IN cord-015021-pol2qm74 4683 9 specific specific JJ cord-015021-pol2qm74 4683 10 protein protein NN cord-015021-pol2qm74 4683 11 factors factor NNS cord-015021-pol2qm74 4683 12 in in IN cord-015021-pol2qm74 4683 13 the the DT cord-015021-pol2qm74 4683 14 cells cell NNS cord-015021-pol2qm74 4683 15 , , , cord-015021-pol2qm74 4683 16 which which WDT cord-015021-pol2qm74 4683 17 act act VBP cord-015021-pol2qm74 4683 18 on on IN cord-015021-pol2qm74 4683 19 the the DT cord-015021-pol2qm74 4683 20 gene gene NN cord-015021-pol2qm74 4683 21 level level NN cord-015021-pol2qm74 4683 22 , , , cord-015021-pol2qm74 4683 23 stimulate stimulate VB cord-015021-pol2qm74 4683 24 IL-2 il-2 NN cord-015021-pol2qm74 4683 25 production production NN cord-015021-pol2qm74 4683 26 and and CC cord-015021-pol2qm74 4683 27 the the DT cord-015021-pol2qm74 4683 28 host host NN cord-015021-pol2qm74 4683 29 resistance resistance NN cord-015021-pol2qm74 4683 30 . . . cord-015021-pol2qm74 4684 1 These these DT cord-015021-pol2qm74 4684 2 results result NNS cord-015021-pol2qm74 4684 3 cause cause VBP cord-015021-pol2qm74 4684 4 the the DT cord-015021-pol2qm74 4684 5 next next JJ cord-015021-pol2qm74 4684 6 step step NN cord-015021-pol2qm74 4684 7 of of IN cord-015021-pol2qm74 4684 8 experiments experiment NNS cord-015021-pol2qm74 4684 9 using use VBG cord-015021-pol2qm74 4684 10 the the DT cord-015021-pol2qm74 4684 11 same same JJ cord-015021-pol2qm74 4684 12 model model NN cord-015021-pol2qm74 4684 13 , , , cord-015021-pol2qm74 4684 14 but but CC cord-015021-pol2qm74 4684 15 after after IN cord-015021-pol2qm74 4684 16 trauma trauma NN cord-015021-pol2qm74 4684 17 . . . cord-015021-pol2qm74 4685 1 These these DT cord-015021-pol2qm74 4685 2 investigations investigation NNS cord-015021-pol2qm74 4685 3 will will MD cord-015021-pol2qm74 4685 4 let let VB cord-015021-pol2qm74 4685 5 us -PRON- PRP cord-015021-pol2qm74 4685 6 verify verify VB cord-015021-pol2qm74 4685 7 the the DT cord-015021-pol2qm74 4685 8 hypothesis hypothesis NN cord-015021-pol2qm74 4685 9 that that IN cord-015021-pol2qm74 4685 10 the the DT cord-015021-pol2qm74 4685 11 protein protein NN cord-015021-pol2qm74 4685 12 IL-2 IL-2 NNP cord-015021-pol2qm74 4685 13 gene gene NN cord-015021-pol2qm74 4685 14 trans trans NNP cord-015021-pol2qm74 4685 15 - - NNS cord-015021-pol2qm74 4685 16 factors factor NNS cord-015021-pol2qm74 4685 17 may may MD cord-015021-pol2qm74 4685 18 play play VB cord-015021-pol2qm74 4685 19 a a DT cord-015021-pol2qm74 4685 20 definite definite JJ cord-015021-pol2qm74 4685 21 role role NN cord-015021-pol2qm74 4685 22 in in IN cord-015021-pol2qm74 4685 23 the the DT cord-015021-pol2qm74 4685 24 decrease decrease NN cord-015021-pol2qm74 4685 25 of of IN cord-015021-pol2qm74 4685 26 the the DT cord-015021-pol2qm74 4685 27 cell cell NN cord-015021-pol2qm74 4685 28 immune immune NN cord-015021-pol2qm74 4685 29 responce responce NN cord-015021-pol2qm74 4685 30 after after IN cord-015021-pol2qm74 4685 31 trauma trauma NN cord-015021-pol2qm74 4685 32 . . . cord-015021-pol2qm74 4686 1 Confronted confront VBN cord-015021-pol2qm74 4686 2 with with IN cord-015021-pol2qm74 4686 3 the the DT cord-015021-pol2qm74 4686 4 routine routine JJ cord-015021-pol2qm74 4686 5 procedure procedure NN cord-015021-pol2qm74 4686 6 of of IN cord-015021-pol2qm74 4686 7 prophylactic prophylactic JJ cord-015021-pol2qm74 4686 8 treatment treatment NN cord-015021-pol2qm74 4686 9 of of IN cord-015021-pol2qm74 4686 10 candidates candidate NNS cord-015021-pol2qm74 4686 11 for for IN cord-015021-pol2qm74 4686 12 surgery surgery NN cord-015021-pol2qm74 4686 13 in in IN cord-015021-pol2qm74 4686 14 a a DT cord-015021-pol2qm74 4686 15 rural rural JJ cord-015021-pol2qm74 4686 16 African african JJ cord-015021-pol2qm74 4686 17 hospital hospital NN cord-015021-pol2qm74 4686 18 , , , cord-015021-pol2qm74 4686 19 we -PRON- PRP cord-015021-pol2qm74 4686 20 initiated initiate VBD cord-015021-pol2qm74 4686 21 studies study NNS cord-015021-pol2qm74 4686 22 on on IN cord-015021-pol2qm74 4686 23 the the DT cord-015021-pol2qm74 4686 24 fre'Quency fre'quency NN cord-015021-pol2qm74 4686 25 of of IN cord-015021-pol2qm74 4686 26 post post JJ cord-015021-pol2qm74 4686 27 - - JJ cord-015021-pol2qm74 4686 28 surgical surgical JJ cord-015021-pol2qm74 4686 29 malaria malaria NN cord-015021-pol2qm74 4686 30 . . . cord-015021-pol2qm74 4687 1 In in IN cord-015021-pol2qm74 4687 2 Tanzania Tanzania NNP cord-015021-pol2qm74 4687 3 195 195 CD cord-015021-pol2qm74 4687 4 non non JJ cord-015021-pol2qm74 4687 5 - - JJ cord-015021-pol2qm74 4687 6 pregnant pregnant JJ cord-015021-pol2qm74 4687 7 patients patient NNS cord-015021-pol2qm74 4687 8 from from IN cord-015021-pol2qm74 4687 9 rural rural JJ cord-015021-pol2qm74 4687 10 areas area NNS cord-015021-pol2qm74 4687 11 were be VBD cord-015021-pol2qm74 4687 12 followed follow VBN cord-015021-pol2qm74 4687 13 . . . cord-015021-pol2qm74 4688 1 Of of IN cord-015021-pol2qm74 4688 2 preoperative preoperative JJ cord-015021-pol2qm74 4688 3 patients patient NNS cord-015021-pol2qm74 4688 4 10 10 CD cord-015021-pol2qm74 4688 5 % % NN cord-015021-pol2qm74 4688 6 had have VBD cord-015021-pol2qm74 4688 7 a a DT cord-015021-pol2qm74 4688 8 parasitaemia parasitaemia NN cord-015021-pol2qm74 4688 9 and and CC cord-015021-pol2qm74 4688 10 those those DT cord-015021-pol2qm74 4688 11 maintaining maintain VBG cord-015021-pol2qm74 4688 12 it -PRON- PRP cord-015021-pol2qm74 4688 13 showed show VBD cord-015021-pol2qm74 4688 14 no no DT cord-015021-pol2qm74 4688 15 increase increase NN cord-015021-pol2qm74 4688 16 or or CC cord-015021-pol2qm74 4688 17 complaints complaint NNS cord-015021-pol2qm74 4688 18 . . . cord-015021-pol2qm74 4689 1 Nine nine CD cord-015021-pol2qm74 4689 2 percent percent NN cord-015021-pol2qm74 4689 3 of of IN cord-015021-pol2qm74 4689 4 patients patient NNS cord-015021-pol2qm74 4689 5 without without IN cord-015021-pol2qm74 4689 6 detectable detectable JJ cord-015021-pol2qm74 4689 7 parasitaemia parasitaemia NN cord-015021-pol2qm74 4689 8 before before IN cord-015021-pol2qm74 4689 9 surgery surgery NN cord-015021-pol2qm74 4689 10 came come VBD cord-015021-pol2qm74 4689 11 down down RP cord-015021-pol2qm74 4689 12 afterwards afterwards RB cord-015021-pol2qm74 4689 13 and and CC cord-015021-pol2qm74 4689 14 one one CD cord-015021-pol2qm74 4689 15 - - HYPH cord-015021-pol2qm74 4689 16 third third NN cord-015021-pol2qm74 4689 17 had have VBD cord-015021-pol2qm74 4689 18 malaria malaria NN cord-015021-pol2qm74 4689 19 - - HYPH cord-015021-pol2qm74 4689 20 like like JJ cord-015021-pol2qm74 4689 21 complaints complaint NNS cord-015021-pol2qm74 4689 22 . . . cord-015021-pol2qm74 4690 1 Spinal spinal JJ cord-015021-pol2qm74 4690 2 and and CC cord-015021-pol2qm74 4690 3 general general JJ cord-015021-pol2qm74 4690 4 anaesthesia anaesthesia NN cord-015021-pol2qm74 4690 5 were be VBD cord-015021-pol2qm74 4690 6 equally equally RB cord-015021-pol2qm74 4690 7 applied apply VBN cord-015021-pol2qm74 4690 8 in in IN cord-015021-pol2qm74 4690 9 these these DT cord-015021-pol2qm74 4690 10 last last JJ cord-015021-pol2qm74 4690 11 patients patient NNS cord-015021-pol2qm74 4690 12 . . . cord-015021-pol2qm74 4691 1 In in IN cord-015021-pol2qm74 4691 2 Burkina Burkina NNP cord-015021-pol2qm74 4691 3 Faso Faso NNP cord-015021-pol2qm74 4691 4 we -PRON- PRP cord-015021-pol2qm74 4691 5 studied study VBD cord-015021-pol2qm74 4691 6 120 120 CD cord-015021-pol2qm74 4691 7 patients patient NNS cord-015021-pol2qm74 4691 8 of of IN cord-015021-pol2qm74 4691 9 which which WDT cord-015021-pol2qm74 4691 10 16 16 CD cord-015021-pol2qm74 4691 11 % % NN cord-015021-pol2qm74 4691 12 had have VBD cord-015021-pol2qm74 4691 13 a a DT cord-015021-pol2qm74 4691 14 parasitaemia parasitaemia NN cord-015021-pol2qm74 4691 15 on on IN cord-015021-pol2qm74 4691 16 admission admission NN cord-015021-pol2qm74 4691 17 and and CC cord-015021-pol2qm74 4691 18 6 6 CD cord-015021-pol2qm74 4691 19 % % NN cord-015021-pol2qm74 4691 20 had have VBD cord-015021-pol2qm74 4691 21 postoperative postoperative JJ cord-015021-pol2qm74 4691 22 malaria malaria NN cord-015021-pol2qm74 4691 23 . . . cord-015021-pol2qm74 4692 1 Half half NN cord-015021-pol2qm74 4692 2 of of IN cord-015021-pol2qm74 4692 3 the the DT cord-015021-pol2qm74 4692 4 surgical surgical JJ cord-015021-pol2qm74 4692 5 patients patient NNS cord-015021-pol2qm74 4692 6 came come VBD cord-015021-pol2qm74 4692 7 from from IN cord-015021-pol2qm74 4692 8 rural rural JJ cord-015021-pol2qm74 4692 9 areas area NNS cord-015021-pol2qm74 4692 10 , , , cord-015021-pol2qm74 4692 11 whilst whilst IN cord-015021-pol2qm74 4692 12 only only RB cord-015021-pol2qm74 4692 13 14 14 CD cord-015021-pol2qm74 4692 14 % % NN cord-015021-pol2qm74 4692 15 of of IN cord-015021-pol2qm74 4692 16 those those DT cord-015021-pol2qm74 4692 17 with with IN cord-015021-pol2qm74 4692 18 malaria malaria NN cord-015021-pol2qm74 4692 19 lived live VBD cord-015021-pol2qm74 4692 20 in in IN cord-015021-pol2qm74 4692 21 the the DT cord-015021-pol2qm74 4692 22 city city NN cord-015021-pol2qm74 4692 23 ( ( -LRB- cord-015021-pol2qm74 4692 24 with with IN cord-015021-pol2qm74 4692 25 much much RB cord-015021-pol2qm74 4692 26 less less JJR cord-015021-pol2qm74 4692 27 exposure exposure NN cord-015021-pol2qm74 4692 28 and and CC cord-015021-pol2qm74 4692 29 immunity immunity NN cord-015021-pol2qm74 4692 30 ) ) -RRB- cord-015021-pol2qm74 4692 31 . . . cord-015021-pol2qm74 4693 1 57 57 CD cord-015021-pol2qm74 4693 2 % % NN cord-015021-pol2qm74 4693 3 underwent undergo VBD cord-015021-pol2qm74 4693 4 major major JJ cord-015021-pol2qm74 4693 5 surgery surgery NN cord-015021-pol2qm74 4693 6 and and CC cord-015021-pol2qm74 4693 7 43 43 CD cord-015021-pol2qm74 4693 8 % % NN cord-015021-pol2qm74 4693 9 minor minor NN cord-015021-pol2qm74 4693 10 . . . cord-015021-pol2qm74 4694 1 Bloodtransfusions bloodtransfusion NNS cord-015021-pol2qm74 4694 2 ( ( -LRB- cord-015021-pol2qm74 4694 3 4 4 CD cord-015021-pol2qm74 4694 4 % % NN cord-015021-pol2qm74 4694 5 with with IN cord-015021-pol2qm74 4694 6 parasites parasite NNS cord-015021-pol2qm74 4694 7 ) ) -RRB- cord-015021-pol2qm74 4694 8 never never RB cord-015021-pol2qm74 4694 9 evoked evoke VBD cord-015021-pol2qm74 4694 10 a a DT cord-015021-pol2qm74 4694 11 parasitaemia parasitaemia NN cord-015021-pol2qm74 4694 12 in in IN cord-015021-pol2qm74 4694 13 recipients recipient NNS cord-015021-pol2qm74 4694 14 . . . cord-015021-pol2qm74 4695 1 Post post JJ cord-015021-pol2qm74 4695 2 - - JJ cord-015021-pol2qm74 4695 3 surgical surgical JJ cord-015021-pol2qm74 4695 4 malaria malaria NN cord-015021-pol2qm74 4695 5 is be VBZ cord-015021-pol2qm74 4695 6 thus thus RB cord-015021-pol2qm74 4695 7 a a DT cord-015021-pol2qm74 4695 8 reality reality NN cord-015021-pol2qm74 4695 9 in in IN cord-015021-pol2qm74 4695 10 about about RB cord-015021-pol2qm74 4695 11 10 10 CD cord-015021-pol2qm74 4695 12 % % NN cord-015021-pol2qm74 4695 13 of of IN cord-015021-pol2qm74 4695 14 the the DT cord-015021-pol2qm74 4695 15 adult adult NN cord-015021-pol2qm74 4695 16 cases case NNS cord-015021-pol2qm74 4695 17 , , , cord-015021-pol2qm74 4695 18 both both CC cord-015021-pol2qm74 4695 19 in in IN cord-015021-pol2qm74 4695 20 East East NNP cord-015021-pol2qm74 4695 21 and and CC cord-015021-pol2qm74 4695 22 West West NNP cord-015021-pol2qm74 4695 23 Africa Africa NNP cord-015021-pol2qm74 4695 24 . . . cord-015021-pol2qm74 4696 1 Surgery surgery NN cord-015021-pol2qm74 4696 2 evokes evoke VBZ cord-015021-pol2qm74 4696 3 a a DT cord-015021-pol2qm74 4696 4 cascade cascade NN cord-015021-pol2qm74 4696 5 of of IN cord-015021-pol2qm74 4696 6 factors factor NNS cord-015021-pol2qm74 4696 7 , , , cord-015021-pol2qm74 4696 8 varying vary VBG cord-015021-pol2qm74 4696 9 from from IN cord-015021-pol2qm74 4696 10 cortison cortison NNP cord-015021-pol2qm74 4696 11 to to IN cord-015021-pol2qm74 4696 12 interleukines interleukines NNP cord-015021-pol2qm74 4696 13 and and CC cord-015021-pol2qm74 4696 14 acute acute JJ cord-015021-pol2qm74 4696 15 phase phase NN cord-015021-pol2qm74 4696 16 proteins protein NNS cord-015021-pol2qm74 4696 17 ; ; : cord-015021-pol2qm74 4696 18 immune immune JJ cord-015021-pol2qm74 4696 19 responses response NNS cord-015021-pol2qm74 4696 20 may may MD cord-015021-pol2qm74 4696 21 temporarily temporarily RB cord-015021-pol2qm74 4696 22 be be VB cord-015021-pol2qm74 4696 23 suppressed suppress VBN cord-015021-pol2qm74 4696 24 . . . cord-015021-pol2qm74 4697 1 Clinical clinical JJ cord-015021-pol2qm74 4697 2 attacks attack NNS cord-015021-pol2qm74 4697 3 of of IN cord-015021-pol2qm74 4697 4 malaria malaria NN cord-015021-pol2qm74 4697 5 in in IN cord-015021-pol2qm74 4697 6 otherwise otherwise RB cord-015021-pol2qm74 4697 7 immunes immune NNS cord-015021-pol2qm74 4697 8 could could MD cord-015021-pol2qm74 4697 9 be be VB cord-015021-pol2qm74 4697 10 evoked evoke VBN cord-015021-pol2qm74 4697 11 by by IN cord-015021-pol2qm74 4697 12 one one CD cord-015021-pol2qm74 4697 13 of of IN cord-015021-pol2qm74 4697 14 these these DT cord-015021-pol2qm74 4697 15 factors factor NNS cord-015021-pol2qm74 4697 16 . . . cord-015021-pol2qm74 4698 1 Though though IN cord-015021-pol2qm74 4698 2 malaria malaria NN cord-015021-pol2qm74 4698 3 can can MD cord-015021-pol2qm74 4698 4 easily easily RB cord-015021-pol2qm74 4698 5 be be VB cord-015021-pol2qm74 4698 6 cured cure VBN cord-015021-pol2qm74 4698 7 , , , cord-015021-pol2qm74 4698 8 the the DT cord-015021-pol2qm74 4698 9 differential differential JJ cord-015021-pol2qm74 4698 10 diagnosis diagnosis NN cord-015021-pol2qm74 4698 11 is be VBZ cord-015021-pol2qm74 4698 12 difficult difficult JJ cord-015021-pol2qm74 4698 13 because because IN cord-015021-pol2qm74 4698 14 of of IN cord-015021-pol2qm74 4698 15 post post JJ cord-015021-pol2qm74 4698 16 - - JJ cord-015021-pol2qm74 4698 17 surgery surgery JJ cord-015021-pol2qm74 4698 18 fevers fever NNS cord-015021-pol2qm74 4698 19 ; ; : cord-015021-pol2qm74 4698 20 we -PRON- PRP cord-015021-pol2qm74 4698 21 found find VBD cord-015021-pol2qm74 4698 22 that that IN cord-015021-pol2qm74 4698 23 16 16 CD cord-015021-pol2qm74 4698 24 % % NN cord-015021-pol2qm74 4698 25 was be VBD cord-015021-pol2qm74 4698 26 treated treat VBN cord-015021-pol2qm74 4698 27 without without IN cord-015021-pol2qm74 4698 28 justified justified JJ cord-015021-pol2qm74 4698 29 indication indication NN cord-015021-pol2qm74 4698 30 . . . cord-015021-pol2qm74 4699 1 The the DT cord-015021-pol2qm74 4699 2 involvement involvement NN cord-015021-pol2qm74 4699 3 of of IN cord-015021-pol2qm74 4699 4 " " `` cord-015021-pol2qm74 4699 5 student student NN cord-015021-pol2qm74 4699 6 - - HYPH cord-015021-pol2qm74 4699 7 doctors doctor NNS cord-015021-pol2qm74 4699 8 " " '' cord-015021-pol2qm74 4699 9 A. a. NN cord-015021-pol2qm74 4700 1 This this DT cord-015021-pol2qm74 4700 2 study study NN cord-015021-pol2qm74 4700 3 examines examine VBZ cord-015021-pol2qm74 4700 4 glucose glucose NN cord-015021-pol2qm74 4700 5 uptake uptake NN cord-015021-pol2qm74 4700 6 and and CC cord-015021-pol2qm74 4700 7 hexose hexose NN cord-015021-pol2qm74 4700 8 monophosphate monophosphate NN cord-015021-pol2qm74 4700 9 ( ( -LRB- cord-015021-pol2qm74 4700 10 I i NN cord-015021-pol2qm74 4700 11 ~ ~ NFP cord-015021-pol2qm74 4700 12 IP ip NN cord-015021-pol2qm74 4700 13 ) ) -RRB- cord-015021-pol2qm74 4700 14 shunt shunt NN cord-015021-pol2qm74 4700 15 activity activity NN cord-015021-pol2qm74 4700 16 in in IN cord-015021-pol2qm74 4700 17 normal normal JJ cord-015021-pol2qm74 4700 18 human human JJ cord-015021-pol2qm74 4700 19 peripheral peripheral JJ cord-015021-pol2qm74 4700 20 lymphocytes lymphocyte NNS cord-015021-pol2qm74 4700 21 and and CC cord-015021-pol2qm74 4700 22 polymorphonuclear polymorphonuclear NN cord-015021-pol2qm74 4700 23 leukocytes leukocyte NNS cord-015021-pol2qm74 4700 24 ( ( -LRB- cord-015021-pol2qm74 4700 25 PMN PMN NNP cord-015021-pol2qm74 4700 26 ) ) -RRB- cord-015021-pol2qm74 4700 27 . . . cord-015021-pol2qm74 4701 1 Glucose glucose NN cord-015021-pol2qm74 4701 2 uptake uptake NN cord-015021-pol2qm74 4701 3 was be VBD cord-015021-pol2qm74 4701 4 determined determine VBN cord-015021-pol2qm74 4701 5 by by IN cord-015021-pol2qm74 4701 6 measurir measurir NNP cord-015021-pol2qm74 4701 7 , , , cord-015021-pol2qm74 4701 8 g g NNP cord-015021-pol2qm74 4701 9 the the DT cord-015021-pol2qm74 4701 10 uptake uptake NN cord-015021-pol2qm74 4701 11 of of IN cord-015021-pol2qm74 4701 12 tritiated tritiated NNP cord-015021-pol2qm74 4701 13 deoxyglucose deoxyglucose NNP cord-015021-pol2qm74 4701 14 , , , cord-015021-pol2qm74 4701 15 a a DT cord-015021-pol2qm74 4701 16 non non JJ cord-015021-pol2qm74 4701 17 - - JJ cord-015021-pol2qm74 4701 18 metabolized metabolized JJ cord-015021-pol2qm74 4701 19 glucose glucose NN cord-015021-pol2qm74 4701 20 analogue analogue NN cord-015021-pol2qm74 4701 21 . . . cord-015021-pol2qm74 4702 1 Adsorption Adsorption NNP cord-015021-pol2qm74 4702 2 of of IN cord-015021-pol2qm74 4702 3 CO2 CO2 NNP cord-015021-pol2qm74 4702 4 derived derive VBN cord-015021-pol2qm74 4702 5 from from IN cord-015021-pol2qm74 4702 6 [ [ -LRB- cord-015021-pol2qm74 4702 7 I-14C i-14c NN cord-015021-pol2qm74 4702 8 ] ] -RRB- cord-015021-pol2qm74 4702 9 glucose glucose NN cord-015021-pol2qm74 4702 10 was be VBD cord-015021-pol2qm74 4702 11 used use VBN cord-015021-pol2qm74 4702 12 to to TO cord-015021-pol2qm74 4702 13 determine determine VB cord-015021-pol2qm74 4702 14 kNP kNP NNP cord-015021-pol2qm74 4702 15 shunt shunt VB cord-015021-pol2qm74 4702 16 activity activity NN cord-015021-pol2qm74 4702 17 . . . cord-015021-pol2qm74 4703 1 In in IN cord-015021-pol2qm74 4703 2 vitro vitro FW cord-015021-pol2qm74 4703 3 assays assay NNS cord-015021-pol2qm74 4703 4 were be VBD cord-015021-pol2qm74 4703 5 carried carry VBN cord-015021-pol2qm74 4703 6 out out RP cord-015021-pol2qm74 4703 7 in in IN cord-015021-pol2qm74 4703 8 hormone hormone NN cord-015021-pol2qm74 4703 9 concentrations concentration NNS cord-015021-pol2qm74 4703 10 approximating approximate VBG cord-015021-pol2qm74 4703 11 normal normal JJ cord-015021-pol2qm74 4703 12 and and CC cord-015021-pol2qm74 4703 13 elevated elevated JJ cord-015021-pol2qm74 4703 14 trauma trauma NN cord-015021-pol2qm74 4703 15 blood blood NN cord-015021-pol2qm74 4703 16 levels level NNS cord-015021-pol2qm74 4703 17 . . . cord-015021-pol2qm74 4704 1 ( ( -LRB- cord-015021-pol2qm74 4704 2 Normal normal JJ cord-015021-pol2qm74 4704 3 -cortisol -cortisol NNP cord-015021-pol2qm74 4704 4 0.12 0.12 CD cord-015021-pol2qm74 4705 1 ~g ~g NNP cord-015021-pol2qm74 4706 1 /ml /ml NFP cord-015021-pol2qm74 4706 2 , , , cord-015021-pol2qm74 4707 1 glucagon glucagon NN cord-015021-pol2qm74 4707 2 80 80 CD cord-015021-pol2qm74 4707 3 # # $ cord-015021-pol2qm74 4707 4 g g NN cord-015021-pol2qm74 4707 5 / / SYM cord-015021-pol2qm74 4707 6 m1 m1 NNP cord-015021-pol2qm74 4707 7 , , , cord-015021-pol2qm74 4707 8 epinephrine epinephrine NN cord-015021-pol2qm74 4707 9 20 20 CD cord-015021-pol2qm74 4708 1 ~g ~g NNP cord-015021-pol2qm74 4708 2 / / SYM cord-015021-pol2qm74 4708 3 ml ml NN cord-015021-pol2qm74 4708 4 , , , cord-015021-pol2qm74 4708 5 insulin insulin NN cord-015021-pol2qm74 4708 6 18 18 CD cord-015021-pol2qm74 4708 7 t t NN cord-015021-pol2qm74 4709 1 ~U ~U NFP cord-015021-pol2qm74 4709 2 / / SYM cord-015021-pol2qm74 4709 3 ml ml XX cord-015021-pol2qm74 4709 4 ; ; : cord-015021-pol2qm74 4709 5 Traumaeortisol Traumaeortisol NNP cord-015021-pol2qm74 4709 6 0.40 0.40 CD cord-015021-pol2qm74 4710 1 ~g ~g NNP cord-015021-pol2qm74 4710 2 / / SYM cord-015021-pol2qm74 4710 3 ml ml XX cord-015021-pol2qm74 4710 4 , , , cord-015021-pol2qm74 4711 1 glucagon glucagon NNP cord-015021-pol2qm74 4712 1 500 500 CD cord-015021-pol2qm74 4712 2 /*g /*g NN cord-015021-pol2qm74 4712 3 / / SYM cord-015021-pol2qm74 4712 4 ml ml NN cord-015021-pol2qm74 4712 5 , , , cord-015021-pol2qm74 4712 6 epinephrine epinephrine NN cord-015021-pol2qm74 4712 7 420~g 420~g CD cord-015021-pol2qm74 4712 8 / / SYM cord-015021-pol2qm74 4712 9 ml ml NN cord-015021-pol2qm74 4712 10 , , , cord-015021-pol2qm74 4712 11 insulin insulin NN cord-015021-pol2qm74 4712 12 36 36 CD cord-015021-pol2qm74 4713 1 ~IJ ~ij LS cord-015021-pol2qm74 4713 2 / / SYM cord-015021-pol2qm74 4713 3 ml ml NN cord-015021-pol2qm74 4713 4 . . . cord-015021-pol2qm74 4714 1 Analysis analysis NN cord-015021-pol2qm74 4714 2 of of IN cord-015021-pol2qm74 4714 3 twenty twenty CD cord-015021-pol2qm74 4714 4 subjects subject NNS cord-015021-pol2qm74 4714 5 showed show VBD cord-015021-pol2qm74 4714 6 a a DT cord-015021-pol2qm74 4714 7 reduction reduction NN cord-015021-pol2qm74 4714 8 of of IN cord-015021-pol2qm74 4714 9 207 207 CD cord-015021-pol2qm74 4714 10 ° ° NN cord-015021-pol2qm74 4714 11 ~MP ~MP . cord-015021-pol2qm74 4715 1 shunt shunt NN cord-015021-pol2qm74 4715 2 activity activity NN cord-015021-pol2qm74 4715 3 by by IN cord-015021-pol2qm74 4715 4 lymphoeytes lymphoeytes NNP cord-015021-pol2qm74 4715 5 and and CC cord-015021-pol2qm74 4715 6 a a LS cord-015021-pol2qm74 4715 7 ] ] -RRB- cord-015021-pol2qm74 4715 8 3 3 CD cord-015021-pol2qm74 4715 9 % % NN cord-015021-pol2qm74 4715 10 reduction reduction NN cord-015021-pol2qm74 4715 11 in in IN cord-015021-pol2qm74 4715 12 glucose glucose NN cord-015021-pol2qm74 4715 13 uptake uptake NN cord-015021-pol2qm74 4715 14 by by IN cord-015021-pol2qm74 4715 15 P p NN cord-015021-pol2qm74 4716 1 ~N ~N NFP cord-015021-pol2qm74 4716 2 in in IN cord-015021-pol2qm74 4716 3 normal normal JJ cord-015021-pol2qm74 4716 4 vs. vs. IN cord-015021-pol2qm74 4716 5 trauma trauma NN cord-015021-pol2qm74 4716 6 honTc honTc NNP cord-015021-pol2qm74 4716 7 , , , cord-015021-pol2qm74 4716 8 nes nes NNP cord-015021-pol2qm74 4716 9 p p NNP cord-015021-pol2qm74 4716 10 < < NNP cord-015021-pol2qm74 4716 11 0.05 0.05 CD cord-015021-pol2qm74 4716 12 . . . cord-015021-pol2qm74 4717 1 Lymphocyte lymphocyte NN cord-015021-pol2qm74 4717 2 glucose glucose NN cord-015021-pol2qm74 4717 3 uptake uptake NN cord-015021-pol2qm74 4717 4 was be VBD cord-015021-pol2qm74 4717 5 also also RB cord-015021-pol2qm74 4717 6 reduced reduce VBN cord-015021-pol2qm74 4717 7 by by IN cord-015021-pol2qm74 4717 8 trauma trauma NN cord-015021-pol2qm74 4717 9 hormones hormone NNS cord-015021-pol2qm74 4717 10 p~0.05 p~0.05 NNP cord-015021-pol2qm74 4717 11 . . . cord-015021-pol2qm74 4718 1 It -PRON- PRP cord-015021-pol2qm74 4718 2 ha~ ha~ VBD cord-015021-pol2qm74 4718 3 be.ea~ be.ea~ NNP cord-015021-pol2qm74 4718 4 suggested suggest VBD cord-015021-pol2qm74 4718 5 thgt thgt NNP cord-015021-pol2qm74 4718 6 idiopatNo idiopatNo NNP cord-015021-pol2qm74 4718 7 pulmonary pulmonary JJ cord-015021-pol2qm74 4718 8 fibrous fibrous NN cord-015021-pol2qm74 4718 9 ( ( -LRB- cord-015021-pol2qm74 4718 10 Y.PF Y.PF NNP cord-015021-pol2qm74 4718 11 ) ) -RRB- cord-015021-pol2qm74 4718 12 [ [ -LRB- cord-015021-pol2qm74 4718 13 s s VBZ cord-015021-pol2qm74 4718 14 a a DT cord-015021-pol2qm74 4718 15 consequence consequence NN cord-015021-pol2qm74 4718 16 of of IN cord-015021-pol2qm74 4718 17 severe severe JJ cord-015021-pol2qm74 4718 18 alveolar alveolar JJ cord-015021-pol2qm74 4718 19 epithelial epithelial JJ cord-015021-pol2qm74 4718 20 injury injury NN cord-015021-pol2qm74 4718 21 and and CC cord-015021-pol2qm74 4718 22 is be VBZ cord-015021-pol2qm74 4718 23 associated associate VBN cord-015021-pol2qm74 4718 24 with with IN cord-015021-pol2qm74 4718 25 an an DT cord-015021-pol2qm74 4718 26 Nveolar Nveolar NNP cord-015021-pol2qm74 4718 27 irNammamry irNammamry NNPS cord-015021-pol2qm74 4718 28 reactio~ reactio~ NNS cord-015021-pol2qm74 4718 29 and and CC cord-015021-pol2qm74 4718 30 the the DT cord-015021-pol2qm74 4718 31 presence presence NN cord-015021-pol2qm74 4718 32 0f.neutr0phils 0f.neutr0phils CD cord-015021-pol2qm74 4718 33 . . . cord-015021-pol2qm74 4719 1 There there RB cord-015021-pol2qm74 4719 2 ~ ~ NFP cord-015021-pol2qm74 4719 3 bre bre NNP cord-015021-pol2qm74 4719 4 , , , cord-015021-pol2qm74 4719 5 neutr0pk~ neutr0pk~ NNP cord-015021-pol2qm74 4719 6 chemoattra chemoattra NNP cord-015021-pol2qm74 4719 7 ~ ~ NFP cord-015021-pol2qm74 4719 8 ant~ ant~ NNP cord-015021-pol2qm74 4719 9 are be VBP cord-015021-pol2qm74 4719 10 probably probably RB cord-015021-pol2qm74 4719 11 important important JJ cord-015021-pol2qm74 4719 12 in in IN cord-015021-pol2qm74 4719 13 the the DT cord-015021-pol2qm74 4719 14 genegs genegs NNP cord-015021-pol2qm74 4719 15 oft.he oft.he NNP cord-015021-pol2qm74 4719 16 iNfial iNfial NNP cord-015021-pol2qm74 4719 17 lesions lesion NNS cord-015021-pol2qm74 4719 18 of of IN cord-015021-pol2qm74 4719 19 IPF IPF NNP cord-015021-pol2qm74 4719 20 . . . cord-015021-pol2qm74 4720 1 The the DT cord-015021-pol2qm74 4720 2 obse,"wSon obse,"wSon NNP cord-015021-pol2qm74 4720 3 that that WDT cord-015021-pol2qm74 4720 4 stimulated stimulate VBD cord-015021-pol2qm74 4720 5 macrophages macrophage NNS cord-015021-pol2qm74 4720 6 are be VBP cord-015021-pol2qm74 4720 7 oR or CC cord-015021-pol2qm74 4720 8 ~ ~ NFP cord-015021-pol2qm74 4720 9 n n XX cord-015021-pol2qm74 4720 10 histologically histologically RB cord-015021-pol2qm74 4720 11 promin promin NNP cord-015021-pol2qm74 4721 1 ~t ~t JJ cord-015021-pol2qm74 4721 2 in in IN cord-015021-pol2qm74 4721 3 fibmfio fibmfio FW cord-015021-pol2qm74 4721 4 [ [ -LRB- cord-015021-pol2qm74 4721 5 -~gs -~gs NFP cord-015021-pol2qm74 4721 6 ~.nd ~.nd NNP cord-015021-pol2qm74 4721 7 am be VBP cord-015021-pol2qm74 4721 8 capable capable JJ cord-015021-pol2qm74 4721 9 of of IN cord-015021-pol2qm74 4721 10 p p NN cord-015021-pol2qm74 4721 11 ~ ~ CD cord-015021-pol2qm74 4721 12 oducmg oducmg NNP cord-015021-pol2qm74 4721 13 a a DT cord-015021-pol2qm74 4721 14 v v NN cord-015021-pol2qm74 4722 1 ~dery ~dery NNP cord-015021-pol2qm74 4722 2 0f 0f NFP cord-015021-pol2qm74 4722 3 flbrogenic flbrogenic NNP cord-015021-pol2qm74 4722 4 pep'ides pep'ides NNP cord-015021-pol2qm74 4722 5 also also RB cord-015021-pol2qm74 4722 6 a a LS cord-015021-pol2qm74 4722 7 ~ ~ NFP cord-015021-pol2qm74 4722 8 gues gue NNS cord-015021-pol2qm74 4722 9 for for IN cord-015021-pol2qm74 4722 10 their -PRON- PRP$ cord-015021-pol2qm74 4722 11 role role NN cord-015021-pol2qm74 4722 12 ~n ~n NNP cord-015021-pol2qm74 4723 1 the the DT cord-015021-pol2qm74 4723 2 pathogenic pathogenic JJ cord-015021-pol2qm74 4723 3 prc~ prc~ CD cord-015021-pol2qm74 4724 1 e~ e~ NFP cord-015021-pol2qm74 4724 2 oflPF oflpf NN cord-015021-pol2qm74 4724 3 . . . cord-015021-pol2qm74 4725 1 The the DT cord-015021-pol2qm74 4725 2 observation observation NN cord-015021-pol2qm74 4725 3 that that IN cord-015021-pol2qm74 4725 4 stimuMe~ stimuMe~ NNP cord-015021-pol2qm74 4725 5 maerophages maerophage NNS cord-015021-pol2qm74 4725 6 ere ere VBP cord-015021-pol2qm74 4725 7 often often RB cord-015021-pol2qm74 4725 8 histologica[Iy histologica[iy VBP cord-015021-pol2qm74 4725 9 prominent prominent JJ cord-015021-pol2qm74 4725 10 in in IN cord-015021-pol2qm74 4725 11 fibrotio fibrotio NNP cord-015021-pol2qm74 4725 12 lungs lung NNS cord-015021-pol2qm74 4725 13 and and CC cord-015021-pol2qm74 4725 14 ~re ~re NN cord-015021-pol2qm74 4725 15 ~pable ~pable XX cord-015021-pol2qm74 4725 16 of of IN cord-015021-pol2qm74 4725 17 producing produce VBG cord-015021-pol2qm74 4725 18 a a DT cord-015021-pol2qm74 4725 19 varie~ varie~ NN cord-015021-pol2qm74 4725 20 , , , cord-015021-pol2qm74 4725 21 offibroge.~e offibroge.~e NN cord-015021-pol2qm74 4725 22 peptide~ peptide~ , cord-015021-pol2qm74 4725 23 also also RB cord-015021-pol2qm74 4725 24 argues argue VBZ cord-015021-pol2qm74 4725 25 for for IN cord-015021-pol2qm74 4725 26 tkek tkek NNP cord-015021-pol2qm74 4725 27 role role NN cord-015021-pol2qm74 4725 28 in in IN cord-015021-pol2qm74 4725 29 the the DT cord-015021-pol2qm74 4725 30 pathogenic pathogenic JJ cord-015021-pol2qm74 4725 31 process process NN cord-015021-pol2qm74 4725 32 , , , cord-015021-pol2qm74 4725 33 Therefore therefore RB cord-015021-pol2qm74 4725 34 , , , cord-015021-pol2qm74 4725 35 we -PRON- PRP cord-015021-pol2qm74 4725 36 ha-~e ha-~e RB cord-015021-pol2qm74 4725 37 tested test VBD cord-015021-pol2qm74 4725 38 the the DT cord-015021-pol2qm74 4725 39 potentN potentN NNP cord-015021-pol2qm74 4725 40 for for IN cord-015021-pol2qm74 4725 41 iater!eukln-8 iater!eukln-8 NNP cord-015021-pol2qm74 4726 1 ( ( -LRB- cord-015021-pol2qm74 4726 2 I1 i1 NN cord-015021-pol2qm74 4726 3 .. .. . cord-015021-pol2qm74 4726 4 -8 -8 NNP cord-015021-pol2qm74 4726 5 ) ) -RRB- cord-015021-pol2qm74 4726 6 and and CC cord-015021-pol2qm74 4726 7 mo mo NNP cord-015021-pol2qm74 4726 8 ~ ~ NNP cord-015021-pol2qm74 4726 9 tocyte tocyte NNP cord-015021-pol2qm74 4726 10 chemotacde chemotacde NNP cord-015021-pol2qm74 4726 11 pop pop NNP cord-015021-pol2qm74 4726 12 , , , cord-015021-pol2qm74 4726 13 de de NNP cord-015021-pol2qm74 4726 14 1 1 CD cord-015021-pol2qm74 4726 15 ( ( -LRB- cord-015021-pol2qm74 4726 16 X¢CP-1 X¢CP-1 NNP cord-015021-pol2qm74 4726 17 ) ) -RRB- cord-015021-pol2qm74 4727 1 to to TO cord-015021-pol2qm74 4727 2 induce induce VB cord-015021-pol2qm74 4727 3 neutro neutro NNP cord-015021-pol2qm74 4727 4 ~ ~ NFP cord-015021-pol2qm74 4727 5 hil hil NNP cord-015021-pol2qm74 4728 1 ~d ~d NNP cord-015021-pol2qm74 4728 2 mononuclear mononuclear JJ cord-015021-pol2qm74 4729 1 phagocyte phagocyte NNP cord-015021-pol2qm74 4729 2 accumuhdon accumuhdon NNP cord-015021-pol2qm74 4729 3 in in IN cord-015021-pol2qm74 4729 4 lungs lung NNS cord-015021-pol2qm74 4729 5 of of IN cord-015021-pol2qm74 4729 6 pafient~ pafient~ NNP cord-015021-pol2qm74 4729 7 with with IN cord-015021-pol2qm74 4729 8 pulmonary pulmonary NN cord-015021-pol2qm74 4729 9 .~r .~r . cord-015021-pol2qm74 4730 1 ~idosis ~idosis XX cord-015021-pol2qm74 4730 2 and and CC cord-015021-pol2qm74 4730 3 I i NN cord-015021-pol2qm74 4730 4 ~ ~ NFP cord-015021-pol2qm74 4730 5 F. F. NNP cord-015021-pol2qm74 4730 6 Brenet Brenet NNP cord-015021-pol2qm74 4730 7 ~ ~ NFP cord-015021-pol2qm74 4730 8 o.alveolar o.alveolar CD cord-015021-pol2qm74 4730 9 lavabo lavabo NN cord-015021-pol2qm74 4730 10 ( ( -LRB- cord-015021-pol2qm74 4730 11 BAL BAL NNP cord-015021-pol2qm74 4730 12 ) ) -RRB- cord-015021-pol2qm74 4730 13 fluids fluid VBZ cord-015021-pol2qm74 4730 14 from from IN cord-015021-pol2qm74 4730 15 12 12 CD cord-015021-pol2qm74 4730 16 IPF IPF NNP cord-015021-pol2qm74 4730 17 and and CC cord-015021-pol2qm74 4730 18 15 15 CD cord-015021-pol2qm74 4730 19 sar sar NN cord-015021-pol2qm74 4731 1 ~Qidosis ~qidosis CD cord-015021-pol2qm74 4731 2 patient patient NN cord-015021-pol2qm74 4731 3 were be VBD cord-015021-pol2qm74 4731 4 conexntrateA conexntrateA NNP cord-015021-pol2qm74 4731 5 by by IN cord-015021-pol2qm74 4731 6 reversed reverse VBN cord-015021-pol2qm74 4731 7 - - HYPH cord-015021-pol2qm74 4731 8 phase phase NN cord-015021-pol2qm74 4731 9 chromatography chromatography NN cord-015021-pol2qm74 4731 10 , , , cord-015021-pol2qm74 4731 11 ~d ~d ADD cord-015021-pol2qm74 4732 1 II.4 ii.4 XX cord-015021-pol2qm74 4733 1 arid arid NNP cord-015021-pol2qm74 4733 2 MCP- MCP- NNP cord-015021-pol2qm74 4734 1 I -PRON- PRP cord-015021-pol2qm74 4735 1 asso.~ed asso.~ed NNP cord-015021-pol2qm74 4735 2 by by IN cord-015021-pol2qm74 4735 3 ELLS ELLS NNP cord-015021-pol2qm74 4735 4 & & CC cord-015021-pol2qm74 4735 5 ehemotaxis ehemotaxis NNP cord-015021-pol2qm74 4736 1 mad mad JJ cord-015021-pol2qm74 4736 2 enzyme enzyme NN cord-015021-pol2qm74 4736 3 - - HYPH cord-015021-pol2qm74 4736 4 reieasing reiease VBG cord-015021-pol2qm74 4737 1 ~ssas ~ssas NNP cord-015021-pol2qm74 4737 2 's be VBZ cord-015021-pol2qm74 4737 3 on on IN cord-015021-pol2qm74 4737 4 msnocyte~ msnocyte~ NNP cord-015021-pol2qm74 4737 5 and and CC cord-015021-pol2qm74 4737 6 neatrophiis neatrophiis NNP cord-015021-pol2qm74 4737 7 . . . cord-015021-pol2qm74 4738 1 ELISA ELISA NNP cord-015021-pol2qm74 4738 2 revealed reveal VBD cord-015021-pol2qm74 4738 3 significenfly significenfly NNP cord-015021-pol2qm74 4738 4 elevated elevate VBD cord-015021-pol2qm74 4738 5 B B NNP cord-015021-pol2qm74 4738 6 AL AL NNP cord-015021-pol2qm74 4738 7 - - HYPH cord-015021-pol2qm74 4738 8 eoneentrations eoneentrations NNP cord-015021-pol2qm74 4738 9 o£MCP- o£mcp- NN cord-015021-pol2qm74 4739 1 I -PRON- PRP cord-015021-pol2qm74 4739 2 ( ( -LRB- cord-015021-pol2qm74 4739 3 20.1 20.1 CD cord-015021-pol2qm74 4739 4 ng]mg ng]mg NNP cord-015021-pol2qm74 4739 5 aibumm aibumm NNP cord-015021-pol2qm74 4739 6 ) ) -RRB- cord-015021-pol2qm74 4739 7 in in IN cord-015021-pol2qm74 4739 8 purisms purism NNS cord-015021-pol2qm74 4739 9 with with IN cord-015021-pol2qm74 4739 10 p p NN cord-015021-pol2qm74 4739 11 ~ ~ CD cord-015021-pol2qm74 4739 12 monary monary NNP cord-015021-pol2qm74 4739 13 sarcoidodis sarcoidodis NNP cord-015021-pol2qm74 4739 14 artd artd NNP cord-015021-pol2qm74 4739 15 in in IN cord-015021-pol2qm74 4739 16 IPF IPF NNP cord-015021-pol2qm74 4739 17 ( ( -LRB- cord-015021-pol2qm74 4739 18 41.8 41.8 CD cord-015021-pol2qm74 4739 19 ng!mg ng!mg JJ cord-015021-pol2qm74 4739 20 ) ) -RRB- cord-015021-pol2qm74 4739 21 in in IN cord-015021-pol2qm74 4739 22 comparises comparise NNS cord-015021-pol2qm74 4739 23 to to IN cord-015021-pol2qm74 4739 24 1.1 1.1 CD cord-015021-pol2qm74 4739 25 normal normal JJ cord-015021-pol2qm74 4739 26 individuals individual NNS cord-015021-pol2qm74 4739 27 ( ( -LRB- cord-015021-pol2qm74 4739 28 4.24 4.24 CD cord-015021-pol2qm74 4739 29 ng ng NNP cord-015021-pol2qm74 4739 30 / / SYM cord-015021-pol2qm74 4739 31 mg mg NNP cord-015021-pol2qm74 4739 32 ) ) -RRB- cord-015021-pol2qm74 4739 33 and and CC cord-015021-pol2qm74 4739 34 to to IN cord-015021-pol2qm74 4739 35 15 15 CD cord-015021-pol2qm74 4739 36 patients patient NNS cord-015021-pol2qm74 4739 37 w w IN cord-015021-pol2qm74 4739 38 ~ ~ CD cord-015021-pol2qm74 4739 39 th th XX cord-015021-pol2qm74 4739 40 obreic obreic JJ cord-015021-pol2qm74 4739 41 broneNtis broneNtis NNP cord-015021-pol2qm74 4739 42 ( ( -LRB- cord-015021-pol2qm74 4739 43 CB CB NNP cord-015021-pol2qm74 4739 44 ) ) -RRB- cord-015021-pol2qm74 4739 45 ( ( -LRB- cord-015021-pol2qm74 4739 46 ~ ~ NFP cord-015021-pol2qm74 4739 47 , , , cord-015021-pol2qm74 4739 48 16 16 CD cord-015021-pol2qm74 4739 49 rig rig NN cord-015021-pol2qm74 4739 50 / / SYM cord-015021-pol2qm74 4739 51 rag rag NN cord-015021-pol2qm74 4739 52 ) ) -RRB- cord-015021-pol2qm74 4739 53 . . . cord-015021-pol2qm74 4740 1 Similarly similarly RB cord-015021-pol2qm74 4740 2 , , , cord-015021-pol2qm74 4740 3 chemota*dc chemota*dc '' cord-015021-pol2qm74 4740 4 ac ac NN cord-015021-pol2qm74 4740 5 ~ ~ NFP cord-015021-pol2qm74 4740 6 A~ A~ NNPS cord-015021-pol2qm74 4740 7 ' ' POS cord-015021-pol2qm74 4740 8 for for IN cord-015021-pol2qm74 4740 9 monocles monocle NNS cord-015021-pol2qm74 4740 10 ( ( -LRB- cord-015021-pol2qm74 4741 1 MCP-1 MCP-1 NNP cord-015021-pol2qm74 4741 2 e.qu/va]ent e.qu/va]ent NNP cord-015021-pol2qm74 4741 3 ) ) -RRB- cord-015021-pol2qm74 4741 4 was be VBD cord-015021-pol2qm74 4741 5 strongly strongly RB cord-015021-pol2qm74 4741 6 increased increase VBN cord-015021-pol2qm74 4741 7 in in IN cord-015021-pol2qm74 4741 8 sareoidosis sareoidosis NNP cord-015021-pol2qm74 4741 9 ( ( -LRB- cord-015021-pol2qm74 4741 10 86.03 86.03 CD cord-015021-pol2qm74 4741 11 ngJmg ngJmg NNP cord-015021-pol2qm74 4741 12 ) ) -RRB- cord-015021-pol2qm74 4741 13 as as RB cord-015021-pol2qm74 4741 14 well well RB cord-015021-pol2qm74 4741 15 as as IN cord-015021-pol2qm74 4741 16 ~n ~n NNP cord-015021-pol2qm74 4742 1 12F 12F NNP cord-015021-pol2qm74 4742 2 pag pag NNP cord-015021-pol2qm74 4742 3 , , , cord-015021-pol2qm74 4742 4 nts nts NNPS cord-015021-pol2qm74 4742 5 ( ( -LRB- cord-015021-pol2qm74 4742 6 54.47 54.47 CD cord-015021-pol2qm74 4742 7 ng ng NNP cord-015021-pol2qm74 4742 8 / / SYM cord-015021-pol2qm74 4742 9 mg mg NNP cord-015021-pol2qm74 4742 10 ) ) -RRB- cord-015021-pol2qm74 4742 11 . . . cord-015021-pol2qm74 4743 1 Norra.al norra.al CD cord-015021-pol2qm74 4744 1 indlvidu indlvidu NNP cord-015021-pol2qm74 4744 2 ~ ~ NNP cord-015021-pol2qm74 4744 3 s s NNP cord-015021-pol2qm74 4744 4 and and CC cord-015021-pol2qm74 4744 5 CB CB NNP cord-015021-pol2qm74 4744 6 patiants patiants NNP cord-015021-pol2qm74 4744 7 hzd hzd NNP cord-015021-pol2qm74 4744 8 a a DT cord-015021-pol2qm74 4744 9 7 7 CD cord-015021-pol2qm74 4744 10 . . . cord-015021-pol2qm74 4745 1 Or or CC cord-015021-pol2qm74 4745 2 3-fold 3-fold CD cord-015021-pol2qm74 4745 3 lower low JJR cord-015021-pol2qm74 4746 1 ~cn%i ~cn%i NNP cord-015021-pol2qm74 4746 2 ~ ~ NFP cord-015021-pol2qm74 4746 3 y y NNP cord-015021-pol2qm74 4746 4 , , , cord-015021-pol2qm74 4746 5 re re NNP cord-015021-pol2qm74 4746 6 ~ ~ NNP cord-015021-pol2qm74 4746 7 peefively peefively NNP cord-015021-pol2qm74 4746 8 . . . cord-015021-pol2qm74 4747 1 Patients patient NNS cord-015021-pol2qm74 4747 2 with with IN cord-015021-pol2qm74 4747 3 IPF IPF NNP cord-015021-pol2qm74 4747 4 and and CC cord-015021-pol2qm74 4748 1 sarcoidosi~ sarcoidosi~ NNP cord-015021-pol2qm74 4748 2 also also RB cord-015021-pol2qm74 4748 3 h h NN cord-015021-pol2qm74 4748 4 ~ ~ NFP cord-015021-pol2qm74 4748 5 l l NNP cord-015021-pol2qm74 4748 6 eIevated eIevated NNP cord-015021-pol2qm74 4749 1 IL-8 IL-8 NNP cord-015021-pol2qm74 4749 2 IeveI~ IeveI~ NNP cord-015021-pol2qm74 4749 3 ( ( -LRB- cord-015021-pol2qm74 4749 4 15.5 15.5 CD cord-015021-pol2qm74 4749 5 and and CC cord-015021-pol2qm74 4749 6 26.0 26.0 CD cord-015021-pol2qm74 4749 7 rig rig NN cord-015021-pol2qm74 4749 8 / / SYM cord-015021-pol2qm74 4749 9 rag rag NN cord-015021-pol2qm74 4749 10 , , , cord-015021-pol2qm74 4749 11 respe respe NNP cord-015021-pol2qm74 4749 12 ~ ~ NFP cord-015021-pol2qm74 4749 13 veIy veiy NN cord-015021-pol2qm74 4749 14 ; ; : cord-015021-pol2qm74 4749 15 nomzls nomzls NN cord-015021-pol2qm74 4749 16 : : : cord-015021-pol2qm74 4749 17 2.14 2.14 CD cord-015021-pol2qm74 4749 18 rig rig NN cord-015021-pol2qm74 4749 19 / / SYM cord-015021-pol2qm74 4749 20 rag rag NN cord-015021-pol2qm74 4749 21 ; ; : cord-015021-pol2qm74 4749 22 CB cb NN cord-015021-pol2qm74 4749 23 : : : cord-015021-pol2qm74 4750 1 4.23 4.23 CD cord-015021-pol2qm74 4750 2 ng ng NNP cord-015021-pol2qm74 4750 3 / / SYM cord-015021-pol2qm74 4750 4 mg mg NNP cord-015021-pol2qm74 4750 5 ) ) -RRB- cord-015021-pol2qm74 4750 6 mad mad JJ cord-015021-pol2qm74 4750 7 nvatropMI nvatropMI NNP cord-015021-pol2qm74 4750 8 ohemotax~ ohemotax~ JJ cord-015021-pol2qm74 4750 9 ( ( -LRB- cord-015021-pol2qm74 4750 10 60.25 60.25 CD cord-015021-pol2qm74 4750 11 ~'~d ~'~d CD cord-015021-pol2qm74 4750 12 49.68 49.68 CD cord-015021-pol2qm74 4750 13 nNmg nnmg NN cord-015021-pol2qm74 4750 14 , , , cord-015021-pol2qm74 4750 15 res!z res!z NNP cord-015021-pol2qm74 4750 16 ~ ~ NFP cord-015021-pol2qm74 4750 17 ztiveiy ztiveiy NNP cord-015021-pol2qm74 4750 18 ; ; : cord-015021-pol2qm74 4750 19 aormals aormal NNS cord-015021-pol2qm74 4750 20 : : : cord-015021-pol2qm74 4750 21 0.25 0.25 CD cord-015021-pol2qm74 4750 22 ng,'mg ng,'mg NNS cord-015021-pol2qm74 4750 23 ; ; : cord-015021-pol2qm74 4750 24 CB CB NNP cord-015021-pol2qm74 4750 25 : : : cord-015021-pol2qm74 4751 1 1L06 1l06 CD cord-015021-pol2qm74 4751 2 ngmg ngmg NNP cord-015021-pol2qm74 4751 3 ) ) -RRB- cord-015021-pol2qm74 4751 4 . . . cord-015021-pol2qm74 4752 1 These these DT cord-015021-pol2qm74 4752 2 data datum NNS cord-015021-pol2qm74 4752 3 suggest suggest VBP cord-015021-pol2qm74 4752 4 that that IN cord-015021-pol2qm74 4752 5 increased increase VBN cord-015021-pol2qm74 4752 6 Ievels Ievels NNP cord-015021-pol2qm74 4752 7 of of IN cord-015021-pol2qm74 4752 8 borN borN NNP cord-015021-pol2qm74 4752 9 MCP.1 MCP.1 NNP cord-015021-pol2qm74 4753 1 ~d ~d NFP cord-015021-pol2qm74 4753 2 IL-8 IL-8 NNP cord-015021-pol2qm74 4753 3 may may MD cord-015021-pol2qm74 4753 4 be be VB cord-015021-pol2qm74 4753 5 oharacted oharacte VBN cord-015021-pol2qm74 4753 6 ~ ~ NFP cord-015021-pol2qm74 4753 7 tie tie NN cord-015021-pol2qm74 4753 8 for for IN cord-015021-pol2qm74 4753 9 ~arcoidosis ~arcoidosis CD cord-015021-pol2qm74 4753 10 or or CC cord-015021-pol2qm74 4753 11 IPF IPF NNP cord-015021-pol2qm74 4754 1 _ _ NNP cord-015021-pol2qm74 4755 1 It -PRON- PRP cord-015021-pol2qm74 4755 2 appears appear VBZ cord-015021-pol2qm74 4755 3 Iikely iikely RB cord-015021-pol2qm74 4755 4 that that IN cord-015021-pol2qm74 4755 5 both both DT cord-015021-pol2qm74 4755 6 ehernoattraetants ehernoattraetant VBZ cord-015021-pol2qm74 4755 7 ~ontribute ~ontribute NNP cord-015021-pol2qm74 4755 8 to to IN cord-015021-pol2qm74 4755 9 the the DT cord-015021-pol2qm74 4755 10 influx influx JJ cord-015021-pol2qm74 4755 11 ofmonocytes ofmonocyte NNS cord-015021-pol2qm74 4755 12 and and CC cord-015021-pol2qm74 4755 13 neutrophils neutrophil NNS cord-015021-pol2qm74 4755 14 into into IN cord-015021-pol2qm74 4755 15 the the DT cord-015021-pol2qm74 4755 16 pulmonary pulmonary NN cord-015021-pol2qm74 4755 17 alveoIus alveoius NN cord-015021-pol2qm74 4756 1 and and CC cord-015021-pol2qm74 4756 2 interStit interStit NNP cord-015021-pol2qm74 4757 1 ~um ~um NNS cord-015021-pol2qm74 4757 2 in in IN cord-015021-pol2qm74 4757 3 these these DT cord-015021-pol2qm74 4757 4 dlsea dlsea NN cord-015021-pol2qm74 4757 5 ~ ~ . cord-015021-pol2qm74 4757 6 es es XX cord-015021-pol2qm74 4757 7 . . . cord-015021-pol2qm74 4758 1 We -PRON- PRP cord-015021-pol2qm74 4758 2 have have VBP cord-015021-pol2qm74 4758 3 recently recently RB cord-015021-pol2qm74 4758 4 shown show VBN cord-015021-pol2qm74 4758 5 that that IN cord-015021-pol2qm74 4758 6 the the DT cord-015021-pol2qm74 4758 7 combined combined JJ cord-015021-pol2qm74 4758 8 administration administration NN cord-015021-pol2qm74 4758 9 of of IN cord-015021-pol2qm74 4758 10 noninjurious noninjurious JJ cord-015021-pol2qm74 4758 11 doses dose NNS cord-015021-pol2qm74 4758 12 of of IN cord-015021-pol2qm74 4758 13 LPS LPS NNP cord-015021-pol2qm74 4758 14 and and CC cord-015021-pol2qm74 4758 15 PAF PAF NNP cord-015021-pol2qm74 4758 16 in in IN cord-015021-pol2qm74 4758 17 the the DT cord-015021-pol2qm74 4758 18 rat rat NN cord-015021-pol2qm74 4758 19 produce produce VB cord-015021-pol2qm74 4758 20 ARDS ARDS NNP cord-015021-pol2qm74 4758 21 - - HYPH cord-015021-pol2qm74 4758 22 like like JJ cord-015021-pol2qm74 4758 23 lung lung NN cord-015021-pol2qm74 4758 24 injury injury NN cord-015021-pol2qm74 4758 25 characterized characterize VBN cord-015021-pol2qm74 4758 26 by by IN cord-015021-pol2qm74 4758 27 neutrophil neutrophil NN cord-015021-pol2qm74 4758 28 adhesion adhesion NN cord-015021-pol2qm74 4758 29 to to IN cord-015021-pol2qm74 4758 30 lung lung NN cord-015021-pol2qm74 4758 31 capillary capillary NN cord-015021-pol2qm74 4758 32 venules venule NNS cord-015021-pol2qm74 4758 33 , , , cord-015021-pol2qm74 4758 34 neutrophil neutrophil NN cord-015021-pol2qm74 4758 35 accumulation accumulation NN cord-015021-pol2qm74 4758 36 in in IN cord-015021-pol2qm74 4758 37 lung lung NN cord-015021-pol2qm74 4758 38 parenchyma parenchyma NN cord-015021-pol2qm74 4758 39 , , , cord-015021-pol2qm74 4758 40 pulmonary pulmonary JJ cord-015021-pol2qm74 4758 41 edema edema NN cord-015021-pol2qm74 4758 42 , , , cord-015021-pol2qm74 4758 43 and and CC cord-015021-pol2qm74 4758 44 increased increase VBN cord-015021-pol2qm74 4758 45 protein protein NN cord-015021-pol2qm74 4758 46 and and CC cord-015021-pol2qm74 4758 47 neutrophil neutrophil NN cord-015021-pol2qm74 4758 48 count count NN cord-015021-pol2qm74 4758 49 in in IN cord-015021-pol2qm74 4758 50 BAL bal NN cord-015021-pol2qm74 4758 51 fluid fluid NN cord-015021-pol2qm74 4758 52 . . . cord-015021-pol2qm74 4759 1 This this DT cord-015021-pol2qm74 4759 2 new new JJ cord-015021-pol2qm74 4759 3 paradigm paradigm NN cord-015021-pol2qm74 4759 4 of of IN cord-015021-pol2qm74 4759 5 lung lung NN cord-015021-pol2qm74 4759 6 injury injury NN cord-015021-pol2qm74 4759 7 was be VBD cord-015021-pol2qm74 4759 8 associated associate VBN cord-015021-pol2qm74 4759 9 with with IN cord-015021-pol2qm74 4759 10 elevated elevated JJ cord-015021-pol2qm74 4759 11 serum serum NN cord-015021-pol2qm74 4759 12 TNFc~ TNFc~ NNP cord-015021-pol2qm74 4759 13 and and CC cord-015021-pol2qm74 4759 14 pretreatment pretreatment NN cord-015021-pol2qm74 4759 15 with with IN cord-015021-pol2qm74 4759 16 anti anti JJ cord-015021-pol2qm74 4759 17 TNFa TNFa NNP cord-015021-pol2qm74 4759 18 mAb mAb HYPH cord-015021-pol2qm74 4759 19 dose dose NN cord-015021-pol2qm74 4759 20 - - HYPH cord-015021-pol2qm74 4759 21 dependently dependently RB cord-015021-pol2qm74 4759 22 prevented prevent VBD cord-015021-pol2qm74 4759 23 these these DT cord-015021-pol2qm74 4759 24 responses response NNS cord-015021-pol2qm74 4759 25 . . . cord-015021-pol2qm74 4760 1 Also also RB cord-015021-pol2qm74 4760 2 , , , cord-015021-pol2qm74 4760 3 the the DT cord-015021-pol2qm74 4760 4 combined combined JJ cord-015021-pol2qm74 4760 5 administration administration NN cord-015021-pol2qm74 4760 6 of of IN cord-015021-pol2qm74 4760 7 LPS LPS NNP cord-015021-pol2qm74 4760 8 and and CC cord-015021-pol2qm74 4760 9 PAF PAF NNP cord-015021-pol2qm74 4760 10 induced induce VBN cord-015021-pol2qm74 4760 11 lung lung NN cord-015021-pol2qm74 4760 12 mRNA mrna NN cord-015021-pol2qm74 4760 13 levels level NNS cord-015021-pol2qm74 4760 14 of of IN cord-015021-pol2qm74 4760 15 TNFe~ TNFe~ NNS cord-015021-pol2qm74 4760 16 ( ( -LRB- cord-015021-pol2qm74 4760 17 5 5 CD cord-015021-pol2qm74 4760 18 fold fold VB cord-015021-pol2qm74 4760 19 vs. vs. FW cord-015021-pol2qm74 4760 20 LPS LPS NNP cord-015021-pol2qm74 4760 21 or or CC cord-015021-pol2qm74 4760 22 PAF PAF NNP cord-015021-pol2qm74 4760 23 alone alone RB cord-015021-pol2qm74 4760 24 ) ) -RRB- cord-015021-pol2qm74 4760 25 , , , cord-015021-pol2qm74 4760 26 lL lL NNP cord-015021-pol2qm74 4760 27 - - HYPH cord-015021-pol2qm74 4760 28 lg lg NNP cord-015021-pol2qm74 4760 29 ( ( -LRB- cord-015021-pol2qm74 4760 30 80 80 CD cord-015021-pol2qm74 4760 31 fold fold NN cord-015021-pol2qm74 4760 32 ) ) -RRB- cord-015021-pol2qm74 4760 33 , , , cord-015021-pol2qm74 4760 34 KC KC NNP cord-015021-pol2qm74 4760 35 ( ( -LRB- cord-015021-pol2qm74 4760 36 60 60 CD cord-015021-pol2qm74 4760 37 fold fold NN cord-015021-pol2qm74 4760 38 ) ) -RRB- cord-015021-pol2qm74 4760 39 and and CC cord-015021-pol2qm74 4760 40 IL-6 IL-6 NNP cord-015021-pol2qm74 4760 41 . . . cord-015021-pol2qm74 4761 1 Taken take VBN cord-015021-pol2qm74 4761 2 together together RB cord-015021-pol2qm74 4761 3 , , , cord-015021-pol2qm74 4761 4 these these DT cord-015021-pol2qm74 4761 5 data datum NNS cord-015021-pol2qm74 4761 6 suggest suggest VBP cord-015021-pol2qm74 4761 7 that that IN cord-015021-pol2qm74 4761 8 this this DT cord-015021-pol2qm74 4761 9 new new JJ cord-015021-pol2qm74 4761 10 paradigm paradigm NN cord-015021-pol2qm74 4761 11 of of IN cord-015021-pol2qm74 4761 12 lung lung NN cord-015021-pol2qm74 4761 13 injury injury NN cord-015021-pol2qm74 4761 14 is be VBZ cord-015021-pol2qm74 4761 15 cytokinemediated cytokinemediate VBN cord-015021-pol2qm74 4761 16 and and CC cord-015021-pol2qm74 4761 17 that that IN cord-015021-pol2qm74 4761 18 LPS LPS NNP cord-015021-pol2qm74 4761 19 / / SYM cord-015021-pol2qm74 4761 20 PAF PAF NNP cord-015021-pol2qm74 4761 21 in in IN cord-015021-pol2qm74 4761 22 vivo vivo NN cord-015021-pol2qm74 4761 23 can can MD cord-015021-pol2qm74 4761 24 functionally functionally RB cord-015021-pol2qm74 4761 25 couple couple NN cord-015021-pol2qm74 4761 26 to to IN cord-015021-pol2qm74 4761 27 the the DT cord-015021-pol2qm74 4761 28 activation activation NN cord-015021-pol2qm74 4761 29 of of IN cord-015021-pol2qm74 4761 30 gone go VBN cord-015021-pol2qm74 4761 31 expression expression NN cord-015021-pol2qm74 4761 32 of of IN cord-015021-pol2qm74 4761 33 a a DT cord-015021-pol2qm74 4761 34 multi multi JJ cord-015021-pol2qm74 4761 35 - - JJ cord-015021-pol2qm74 4761 36 cytokine cytokine JJ cord-015021-pol2qm74 4761 37 network network NN cord-015021-pol2qm74 4761 38 system system NN cord-015021-pol2qm74 4761 39 , , , cord-015021-pol2qm74 4761 40 all all DT cord-015021-pol2qm74 4761 41 of of IN cord-015021-pol2qm74 4761 42 which which WDT cord-015021-pol2qm74 4761 43 may may MD cord-015021-pol2qm74 4761 44 be be VB cord-015021-pol2qm74 4761 45 involved involve VBN cord-015021-pol2qm74 4761 46 in in IN cord-015021-pol2qm74 4761 47 the the DT cord-015021-pol2qm74 4761 48 pathogenesis pathogenesis NN cord-015021-pol2qm74 4761 49 of of IN cord-015021-pol2qm74 4761 50 ARDS ARDS NNP cord-015021-pol2qm74 4761 51 . . . cord-015021-pol2qm74 4762 1 Materials material NNS cord-015021-pol2qm74 4762 2 and and CC cord-015021-pol2qm74 4762 3 methods method NNS cord-015021-pol2qm74 4762 4 . . . cord-015021-pol2qm74 4763 1 The the DT cord-015021-pol2qm74 4763 2 sheep sheep NN cord-015021-pol2qm74 4763 3 model model NN cord-015021-pol2qm74 4763 4 included include VBD cord-015021-pol2qm74 4763 5 hemorrhagic hemorrhagic JJ cord-015021-pol2qm74 4763 6 shock shock NN cord-015021-pol2qm74 4763 7 and and CC cord-015021-pol2qm74 4763 8 closed closed JJ cord-015021-pol2qm74 4763 9 femoral femoral JJ cord-015021-pol2qm74 4763 10 nailing nailing NN cord-015021-pol2qm74 4763 11 at at IN cord-015021-pol2qm74 4763 12 day day NN cord-015021-pol2qm74 4763 13 0 0 CD cord-015021-pol2qm74 4763 14 , , , cord-015021-pol2qm74 4763 15 12hourly 12hourly JJ cord-015021-pol2qm74 4763 16 injections injection NNS cord-015021-pol2qm74 4763 17 of of IN cord-015021-pol2qm74 4763 18 E. E. NNP cord-015021-pol2qm74 4763 19 coli coli VBZ cord-015021-pol2qm74 4763 20 endotoxin endotoxin NN cord-015021-pol2qm74 4763 21 and and CC cord-015021-pol2qm74 4763 22 zymosan zymosan NNP cord-015021-pol2qm74 4763 23 - - HYPH cord-015021-pol2qm74 4763 24 activated activate VBN cord-015021-pol2qm74 4763 25 autologous autologous JJ cord-015021-pol2qm74 4763 26 plasma plasma NN cord-015021-pol2qm74 4763 27 at at IN cord-015021-pol2qm74 4763 28 clays clay NNS cord-015021-pol2qm74 4763 29 1 1 CD cord-015021-pol2qm74 4763 30 - - SYM cord-015021-pol2qm74 4763 31 5 5 CD cord-015021-pol2qm74 4763 32 and and CC cord-015021-pol2qm74 4763 33 further further JJ cord-015021-pol2qm74 4763 34 observation observation NN cord-015021-pol2qm74 4763 35 and and CC cord-015021-pol2qm74 4763 36 measurements measurement NNS cord-015021-pol2qm74 4763 37 at at IN cord-015021-pol2qm74 4763 38 days day NNS cord-015021-pol2qm74 4763 39 6 6 CD cord-015021-pol2qm74 4763 40 - - SYM cord-015021-pol2qm74 4763 41 10 10 CD cord-015021-pol2qm74 4763 42 . . . cord-015021-pol2qm74 4764 1 From from IN cord-015021-pol2qm74 4764 2 venous venous JJ cord-015021-pol2qm74 4764 3 blood blood NN cord-015021-pol2qm74 4764 4 and and CC cord-015021-pol2qm74 4764 5 bronchoalveolar bronchoalveolar NNP cord-015021-pol2qm74 4764 6 lavage(BAL)fluid lavage(BAL)fluid NNP cord-015021-pol2qm74 4764 7 of of IN cord-015021-pol2qm74 4764 8 ten ten CD cord-015021-pol2qm74 4764 9 merino merino NN cord-015021-pol2qm74 4764 10 sheep sheep NNS cord-015021-pol2qm74 4764 11 ( ( -LRB- cord-015021-pol2qm74 4764 12 mean mean VB cord-015021-pol2qm74 4764 13 weight weight NN cord-015021-pol2qm74 4764 14 30 30 CD cord-015021-pol2qm74 4764 15 kg kg NN cord-015021-pol2qm74 4764 16 ) ) -RRB- cord-015021-pol2qm74 4765 1 neutrophil neutrophil NN cord-015021-pol2qm74 4765 2 counts count NNS cord-015021-pol2qm74 4765 3 ( ( -LRB- cord-015021-pol2qm74 4765 4 10e6 10e6 CD cord-015021-pol2qm74 4765 5 PMN PMN NNP cord-015021-pol2qm74 4765 6 / / , cord-015021-pol2qm74 4765 7 ml ml NN cord-015021-pol2qm74 4765 8 blood blood NN cord-015021-pol2qm74 4765 9 or or CC cord-015021-pol2qm74 4765 10 epithelial epithelial JJ cord-015021-pol2qm74 4765 11 lining line VBG cord-015021-pol2qm74 4765 12 fluid fluid NN cord-015021-pol2qm74 4765 13 - - HYPH cord-015021-pol2qm74 4765 14 ELF- elf- NN cord-015021-pol2qm74 4765 15 ) ) -RRB- cord-015021-pol2qm74 4765 16 , , , cord-015021-pol2qm74 4765 17 the the DT cord-015021-pol2qm74 4765 18 ELF/ elf/ NN cord-015021-pol2qm74 4765 19 plasma plasma NN cord-015021-pol2qm74 4765 20 ratio ratio NN cord-015021-pol2qm74 4765 21 of of IN cord-015021-pol2qm74 4765 22 albumin albumin NN cord-015021-pol2qm74 4765 23 ( ( -LRB- cord-015021-pol2qm74 4765 24 R r NN cord-015021-pol2qm74 4765 25 ) ) -RRB- cord-015021-pol2qm74 4765 26 , , , cord-015021-pol2qm74 4765 27 and and CC cord-015021-pol2qm74 4765 28 the the DT cord-015021-pol2qm74 4765 29 zymosan zymosan NNP cord-015021-pol2qm74 4765 30 - - HYPH cord-015021-pol2qm74 4765 31 induced induce VBN cord-015021-pol2qm74 4765 32 ( ( -LRB- cord-015021-pol2qm74 4765 33 stim stim NNP cord-015021-pol2qm74 4765 34 ) ) -RRB- cord-015021-pol2qm74 4765 35 and and CC cord-015021-pol2qm74 4765 36 non non JJ cord-015021-pol2qm74 4765 37 - - JJ cord-015021-pol2qm74 4765 38 induced induced JJ cord-015021-pol2qm74 4765 39 ( ( -LRB- cord-015021-pol2qm74 4765 40 spont spont NN cord-015021-pol2qm74 4765 41 ) ) -RRB- cord-015021-pol2qm74 4766 1 chemiluminescence chemiluminescence NNP cord-015021-pol2qm74 4766 2 response response NN cord-015021-pol2qm74 4766 3 ( ( -LRB- cord-015021-pol2qm74 4766 4 CL CL NNP cord-015021-pol2qm74 4766 5 ) ) -RRB- cord-015021-pol2qm74 4766 6 of of IN cord-015021-pol2qm74 4766 7 blood blood NN cord-015021-pol2qm74 4766 8 ( ( -LRB- cord-015021-pol2qm74 4766 9 10e6 10e6 CD cord-015021-pol2qm74 4766 10 cpm/250,000 cpm/250,000 : cord-015021-pol2qm74 4766 11 PMN PMN NNP cord-015021-pol2qm74 4766 12 ) ) -RRB- cord-015021-pol2qm74 4766 13 , , , cord-015021-pol2qm74 4766 14 and and CC cord-015021-pol2qm74 4766 15 of of IN cord-015021-pol2qm74 4766 16 blood blood NN cord-015021-pol2qm74 4766 17 - - HYPH cord-015021-pol2qm74 4766 18 and and CC cord-015021-pol2qm74 4766 19 BAL bal NN cord-015021-pol2qm74 4766 20 - - HYPH cord-015021-pol2qm74 4766 21 isolated isolate VBN cord-015021-pol2qm74 4766 22 PMN PMN NNP cord-015021-pol2qm74 4766 23 ( ( -LRB- cord-015021-pol2qm74 4766 24 10e6 10e6 CD cord-015021-pol2qm74 4766 25 cpm/25,000 cpm/25,000 NNP cord-015021-pol2qm74 4766 26 PMN PMN NNP cord-015021-pol2qm74 4766 27 ) ) -RRB- cord-015021-pol2qm74 4766 28 were be VBD cord-015021-pol2qm74 4766 29 measured measure VBN cord-015021-pol2qm74 4766 30 . . . cord-015021-pol2qm74 4767 1 For for IN cord-015021-pol2qm74 4767 2 statistical statistical JJ cord-015021-pol2qm74 4767 3 calculations calculation NNS cord-015021-pol2qm74 4767 4 the the DT cord-015021-pol2qm74 4767 5 Wilcoxon Wilcoxon NNP cord-015021-pol2qm74 4767 6 test test NN cord-015021-pol2qm74 4767 7 was be VBD cord-015021-pol2qm74 4767 8 used use VBN cord-015021-pol2qm74 4767 9 . . . cord-015021-pol2qm74 4768 1 Data datum NNS cord-015021-pol2qm74 4768 2 of of IN cord-015021-pol2qm74 4768 3 the the DT cord-015021-pol2qm74 4768 4 Changes change NNS cord-015021-pol2qm74 4768 5 in in IN cord-015021-pol2qm74 4768 6 polymorphonucleur polymorphonucleur NN cord-015021-pol2qm74 4768 7 leukocyte leukocyte NN cord-015021-pol2qm74 4768 8 ( ( -LRB- cord-015021-pol2qm74 4768 9 PIVINL PIVINL NNP cord-015021-pol2qm74 4768 10 ) ) -RRB- cord-015021-pol2qm74 4768 11 metabolism metabolism NN cord-015021-pol2qm74 4768 12 have have VBP cord-015021-pol2qm74 4768 13 been be VBN cord-015021-pol2qm74 4768 14 suggested suggest VBN cord-015021-pol2qm74 4768 15 to to TO cord-015021-pol2qm74 4768 16 play play VB cord-015021-pol2qm74 4768 17 a a DT cord-015021-pol2qm74 4768 18 pivotal pivotal JJ cord-015021-pol2qm74 4768 19 part part NN cord-015021-pol2qm74 4768 20 in in IN cord-015021-pol2qm74 4768 21 the the DT cord-015021-pol2qm74 4768 22 post post JJ cord-015021-pol2qm74 4768 23 - - JJ cord-015021-pol2qm74 4768 24 traumatic traumatic JJ cord-015021-pol2qm74 4768 25 systemic systemic JJ cord-015021-pol2qm74 4768 26 inflammatory inflammatory JJ cord-015021-pol2qm74 4768 27 response response NN cord-015021-pol2qm74 4768 28 syndrome syndrome NN cord-015021-pol2qm74 4768 29 . . . cord-015021-pol2qm74 4769 1 The the DT cord-015021-pol2qm74 4769 2 underlying underlying JJ cord-015021-pol2qm74 4769 3 cellular cellular JJ cord-015021-pol2qm74 4769 4 mechanisms mechanism NNS cord-015021-pol2qm74 4769 5 which which WDT cord-015021-pol2qm74 4769 6 control control VBP cord-015021-pol2qm74 4769 7 this this DT cord-015021-pol2qm74 4769 8 response response NN cord-015021-pol2qm74 4769 9 are be VBP cord-015021-pol2qm74 4769 10 not not RB cord-015021-pol2qm74 4769 11 yet yet RB cord-015021-pol2qm74 4769 12 completely completely RB cord-015021-pol2qm74 4769 13 understood understand VBN cord-015021-pol2qm74 4769 14 . . . cord-015021-pol2qm74 4770 1 Since since IN cord-015021-pol2qm74 4770 2 the the DT cord-015021-pol2qm74 4770 3 ' ' `` cord-015021-pol2qm74 4770 4 Ca Ca NNP cord-015021-pol2qm74 4770 5 2 2 CD cord-015021-pol2qm74 4770 6 + + SYM cord-015021-pol2qm74 4770 7 second second JJ cord-015021-pol2qm74 4770 8 messenger'-system messenger'-system NNP cord-015021-pol2qm74 4770 9 has have VBZ cord-015021-pol2qm74 4770 10 been be VBN cord-015021-pol2qm74 4770 11 shown show VBN cord-015021-pol2qm74 4770 12 to to TO cord-015021-pol2qm74 4770 13 be be VB cord-015021-pol2qm74 4770 14 involved involve VBN cord-015021-pol2qm74 4770 15 in in IN cord-015021-pol2qm74 4770 16 regulation regulation NN cord-015021-pol2qm74 4770 17 of of IN cord-015021-pol2qm74 4770 18 PMNL-'respiratory pmnl-'respiratory CD cord-015021-pol2qm74 4770 19 burst burst NN cord-015021-pol2qm74 4770 20 ' ' '' cord-015021-pol2qm74 4770 21 , , , cord-015021-pol2qm74 4770 22 we -PRON- PRP cord-015021-pol2qm74 4770 23 investigated investigate VBD cord-015021-pol2qm74 4770 24 changes change NNS cord-015021-pol2qm74 4770 25 in in IN cord-015021-pol2qm74 4770 26 PMNL PMNL NNP cord-015021-pol2qm74 4770 27 - - HYPH cord-015021-pol2qm74 4770 28 Ca Ca NNP cord-015021-pol2qm74 4770 29 z÷ z÷ NN cord-015021-pol2qm74 4770 30 regulation regulation NN cord-015021-pol2qm74 4770 31 in in IN cord-015021-pol2qm74 4770 32 relation relation NN cord-015021-pol2qm74 4770 33 to to IN cord-015021-pol2qm74 4770 34 oxygen oxygen NN cord-015021-pol2qm74 4770 35 free free JJ cord-015021-pol2qm74 4770 36 radical radical JJ cord-015021-pol2qm74 4770 37 mediated mediate VBN cord-015021-pol2qm74 4770 38 injury injury NN cord-015021-pol2qm74 4770 39 . . . cord-015021-pol2qm74 4771 1 Methods method NNS cord-015021-pol2qm74 4771 2 . . . cord-015021-pol2qm74 4772 1 In in IN cord-015021-pol2qm74 4772 2 12 12 CD cord-015021-pol2qm74 4772 3 polytranmatized polytranmatize VBN cord-015021-pol2qm74 4772 4 patients patient NNS cord-015021-pol2qm74 4772 5 ( ( -LRB- cord-015021-pol2qm74 4772 6 mean mean VB cord-015021-pol2qm74 4772 7 injury injury NN cord-015021-pol2qm74 4772 8 severity severity NN cord-015021-pol2qm74 4772 9 score score NN cord-015021-pol2qm74 4772 10 = = SYM cord-015021-pol2qm74 4772 11 32 32 CD cord-015021-pol2qm74 4772 12 ) ) -RRB- cord-015021-pol2qm74 4772 13 arterial arterial JJ cord-015021-pol2qm74 4772 14 and and CC cord-015021-pol2qm74 4772 15 venous venous JJ cord-015021-pol2qm74 4772 16 blood blood NN cord-015021-pol2qm74 4772 17 samples sample NNS cord-015021-pol2qm74 4772 18 during during IN cord-015021-pol2qm74 4772 19 15 15 CD cord-015021-pol2qm74 4772 20 days day NNS cord-015021-pol2qm74 4772 21 . . . cord-015021-pol2qm74 4773 1 Daily daily JJ cord-015021-pol2qm74 4773 2 evaluation evaluation NN cord-015021-pol2qm74 4773 3 of of IN cord-015021-pol2qm74 4773 4 Horowitz Horowitz NNP cord-015021-pol2qm74 4773 5 - - HYPH cord-015021-pol2qm74 4773 6 quotiant quotiant NNP cord-015021-pol2qm74 4773 7 ( ( -LRB- cord-015021-pol2qm74 4773 8 PO2 PO2 NNP cord-015021-pol2qm74 4773 9 / / SYM cord-015021-pol2qm74 4773 10 FiO2 FiO2 NNP cord-015021-pol2qm74 4773 11 ) ) -RRB- cord-015021-pol2qm74 4773 12 , , , cord-015021-pol2qm74 4773 13 plasma plasma NN cord-015021-pol2qm74 4773 14 lactate lactate NN cord-015021-pol2qm74 4773 15 ( ( -LRB- cord-015021-pol2qm74 4773 16 mg mg NNP cord-015021-pol2qm74 4773 17 / / SYM cord-015021-pol2qm74 4773 18 dl dl NNP cord-015021-pol2qm74 4773 19 ) ) -RRB- cord-015021-pol2qm74 4773 20 and and CC cord-015021-pol2qm74 4773 21 body body NN cord-015021-pol2qm74 4773 22 temperature temperature NN cord-015021-pol2qm74 4773 23 ( ( -LRB- cord-015021-pol2qm74 4773 24 Results result NNS cord-015021-pol2qm74 4773 25 . . . cord-015021-pol2qm74 4774 1 Body body NN cord-015021-pol2qm74 4774 2 temperature temperature NN cord-015021-pol2qm74 4774 3 peaked peak VBD cord-015021-pol2qm74 4774 4 at at IN cord-015021-pol2qm74 4774 5 day day NN cord-015021-pol2qm74 4774 6 6 6 CD cord-015021-pol2qm74 4774 7 and and CC cord-015021-pol2qm74 4774 8 7 7 CD cord-015021-pol2qm74 4774 9 ( ( -LRB- cord-015021-pol2qm74 4774 10 day day NN cord-015021-pol2qm74 4774 11 0 0 CD cord-015021-pol2qm74 4774 12 : : : cord-015021-pol2qm74 4774 13 36+.4 36+.4 CD cord-015021-pol2qm74 4774 14 ; ; : cord-015021-pol2qm74 4774 15 day day NN cord-015021-pol2qm74 4774 16 7 7 CD cord-015021-pol2qm74 4774 17 : : SYM cord-015021-pol2qm74 4774 18 39.8+.4 39.8+.4 CD cord-015021-pol2qm74 4774 19 ) ) -RRB- cord-015021-pol2qm74 4774 20 . . . cord-015021-pol2qm74 4775 1 Plasma plasma NN cord-015021-pol2qm74 4775 2 lactate lactate NN cord-015021-pol2qm74 4775 3 was be VBD cord-015021-pol2qm74 4775 4 significantly significantly RB cord-015021-pol2qm74 4775 5 increased increase VBN cord-015021-pol2qm74 4775 6 at at IN cord-015021-pol2qm74 4775 7 day day NN cord-015021-pol2qm74 4775 8 l l NNP cord-015021-pol2qm74 4775 9 ( ( -LRB- cord-015021-pol2qm74 4775 10 36 36 CD cord-015021-pol2qm74 4775 11 + + SYM cord-015021-pol2qm74 4775 12 2 2 CD cord-015021-pol2qm74 4775 13 ) ) -RRB- cord-015021-pol2qm74 4775 14 and and CC cord-015021-pol2qm74 4775 15 day day NN cord-015021-pol2qm74 4775 16 7 7 CD cord-015021-pol2qm74 4775 17 ( ( -LRB- cord-015021-pol2qm74 4775 18 16.2 16.2 CD cord-015021-pol2qm74 4775 19 + + SYM cord-015021-pol2qm74 4775 20 2 2 CD cord-015021-pol2qm74 4775 21 ) ) -RRB- cord-015021-pol2qm74 4775 22 . . . cord-015021-pol2qm74 4776 1 Hurowitz Hurowitz NNP cord-015021-pol2qm74 4776 2 - - HYPH cord-015021-pol2qm74 4776 3 quotient quotient NN cord-015021-pol2qm74 4776 4 ( ( -LRB- cord-015021-pol2qm74 4776 5 day day NN cord-015021-pol2qm74 4776 6 0 0 CD cord-015021-pol2qm74 4776 7 : : : cord-015021-pol2qm74 4776 8 344 344 CD cord-015021-pol2qm74 4776 9 + + SYM cord-015021-pol2qm74 4776 10 43 43 CD cord-015021-pol2qm74 4776 11 ) ) -RRB- cord-015021-pol2qm74 4776 12 was be VBD cord-015021-pol2qm74 4776 13 low low JJ cord-015021-pol2qm74 4776 14 at at IN cord-015021-pol2qm74 4776 15 day day NN cord-015021-pol2qm74 4776 16 4 4 CD cord-015021-pol2qm74 4776 17 ( ( -LRB- cord-015021-pol2qm74 4776 18 199 199 CD cord-015021-pol2qm74 4776 19 + + SYM cord-015021-pol2qm74 4776 20 19 19 CD cord-015021-pol2qm74 4776 21 ) ) -RRB- cord-015021-pol2qm74 4776 22 and and CC cord-015021-pol2qm74 4776 23 day day NN cord-015021-pol2qm74 4776 24 7 7 CD cord-015021-pol2qm74 4776 25 to to IN cord-015021-pol2qm74 4776 26 10 10 CD cord-015021-pol2qm74 4776 27 ( ( -LRB- cord-015021-pol2qm74 4776 28 178 178 CD cord-015021-pol2qm74 4776 29 + + SYM cord-015021-pol2qm74 4776 30 25)(p<.05 25)(p<.05 CD cord-015021-pol2qm74 4776 31 ) ) -RRB- cord-015021-pol2qm74 4776 32 . . . cord-015021-pol2qm74 4777 1 At at IN cord-015021-pol2qm74 4777 2 day day NN cord-015021-pol2qm74 4777 3 7 7 CD cord-015021-pol2qm74 4777 4 a a DT cord-015021-pol2qm74 4777 5 substantial substantial JJ cord-015021-pol2qm74 4777 6 rise rise NN cord-015021-pol2qm74 4777 7 in in IN cord-015021-pol2qm74 4777 8 venous venous JJ cord-015021-pol2qm74 4777 9 PMNL pmnl NN cord-015021-pol2qm74 4777 10 - - HYPH cord-015021-pol2qm74 4777 11 superoxide superoxide NN cord-015021-pol2qm74 4777 12 production production NN cord-015021-pol2qm74 4777 13 ( ( -LRB- cord-015021-pol2qm74 4777 14 day day NN cord-015021-pol2qm74 4777 15 5 5 CD cord-015021-pol2qm74 4777 16 : : : cord-015021-pol2qm74 4778 1 1.9+_.45 1.9+_.45 CD cord-015021-pol2qm74 4778 2 , , , cord-015021-pol2qm74 4778 3 day day NN cord-015021-pol2qm74 4778 4 7 7 CD cord-015021-pol2qm74 4778 5 : : SYM cord-015021-pol2qm74 4778 6 3.3+.7 3.3+.7 CD cord-015021-pol2qm74 4778 7 , , , cord-015021-pol2qm74 4778 8 day day NN cord-015021-pol2qm74 4778 9 9 9 CD cord-015021-pol2qm74 4778 10 : : : cord-015021-pol2qm74 4779 1 1.72+_.8 1.72+_.8 LS cord-015021-pol2qm74 4779 2 ) ) -RRB- cord-015021-pol2qm74 4779 3 , , , cord-015021-pol2qm74 4779 4 oecured oecure VBN cord-015021-pol2qm74 4779 5 with with IN cord-015021-pol2qm74 4779 6 significant significant JJ cord-015021-pol2qm74 4779 7 increase increase NN cord-015021-pol2qm74 4779 8 in in IN cord-015021-pol2qm74 4779 9 plasma plasma NN cord-015021-pol2qm74 4779 10 lipid lipid NN cord-015021-pol2qm74 4779 11 peroxidation peroxidation NN cord-015021-pol2qm74 4779 12 ( ( -LRB- cord-015021-pol2qm74 4779 13 day day NN cord-015021-pol2qm74 4779 14 1:0.6 1:0.6 CD cord-015021-pol2qm74 4779 15 + + SYM cord-015021-pol2qm74 4779 16 0.2 0.2 CD cord-015021-pol2qm74 4779 17 ; ; : cord-015021-pol2qm74 4779 18 day day NN cord-015021-pol2qm74 4779 19 7 7 CD cord-015021-pol2qm74 4779 20 : : SYM cord-015021-pol2qm74 4779 21 1.3 1.3 CD cord-015021-pol2qm74 4779 22 + + SYM cord-015021-pol2qm74 4779 23 0.2 0.2 CD cord-015021-pol2qm74 4779 24 ) ) -RRB- cord-015021-pol2qm74 4779 25 . . . cord-015021-pol2qm74 4780 1 PIVIN~-myeloperoxidase pivin~-myeloperoxidase DT cord-015021-pol2qm74 4780 2 activity activity NN cord-015021-pol2qm74 4780 3 was be VBD cord-015021-pol2qm74 4780 4 high high JJ cord-015021-pol2qm74 4780 5 at at IN cord-015021-pol2qm74 4780 6 day day NN cord-015021-pol2qm74 4780 7 2 2 CD cord-015021-pol2qm74 4780 8 ( ( -LRB- cord-015021-pol2qm74 4780 9 2.3 2.3 CD cord-015021-pol2qm74 4780 10 + + SYM cord-015021-pol2qm74 4780 11 --.5 --.5 NN cord-015021-pol2qm74 4780 12 ) ) -RRB- cord-015021-pol2qm74 4780 13 and and CC cord-015021-pol2qm74 4780 14 then then RB cord-015021-pol2qm74 4780 15 continuously continuously RB cord-015021-pol2qm74 4780 16 declined decline VBD cord-015021-pol2qm74 4780 17 ( ( -LRB- cord-015021-pol2qm74 4780 18 day day NN cord-015021-pol2qm74 4780 19 7 7 CD cord-015021-pol2qm74 4780 20 : : SYM cord-015021-pol2qm74 4780 21 1.3+.3 1.3+.3 CD cord-015021-pol2qm74 4780 22 ) ) -RRB- cord-015021-pol2qm74 4780 23 . . . cord-015021-pol2qm74 4781 1 Plasma plasma NN cord-015021-pol2qm74 4781 2 antiexidant antiexidant JJ cord-015021-pol2qm74 4781 3 activity activity NN cord-015021-pol2qm74 4781 4 ( ( -LRB- cord-015021-pol2qm74 4781 5 glutathione glutathione NN cord-015021-pol2qm74 4781 6 pemxidase pemxidase NN cord-015021-pol2qm74 4781 7 ) ) -RRB- cord-015021-pol2qm74 4781 8 was be VBD cord-015021-pol2qm74 4781 9 reduced reduce VBN cord-015021-pol2qm74 4781 10 by by IN cord-015021-pol2qm74 4781 11 34 34 CD cord-015021-pol2qm74 4781 12 % % NN cord-015021-pol2qm74 4781 13 at at IN cord-015021-pol2qm74 4781 14 day day NN cord-015021-pol2qm74 4781 15 7 7 CD cord-015021-pol2qm74 4781 16 ( ( -LRB- cord-015021-pol2qm74 4781 17 day day NN cord-015021-pol2qm74 4781 18 1 1 CD cord-015021-pol2qm74 4781 19 : : : cord-015021-pol2qm74 4781 20 5.3+.3 5.3+.3 CD cord-015021-pol2qm74 4781 21 ; ; : cord-015021-pol2qm74 4781 22 day day NN cord-015021-pol2qm74 4781 23 4 4 CD cord-015021-pol2qm74 4781 24 : : : cord-015021-pol2qm74 4781 25 4.4+_.2 4.4+_.2 CD cord-015021-pol2qm74 4781 26 ; ; : cord-015021-pol2qm74 4781 27 day day NN cord-015021-pol2qm74 4781 28 7 7 CD cord-015021-pol2qm74 4781 29 : : : cord-015021-pol2qm74 4781 30 3.5+.2 3.5+.2 CD cord-015021-pol2qm74 4781 31 ) ) -RRB- cord-015021-pol2qm74 4781 32 . . . cord-015021-pol2qm74 4782 1 Whereas whereas IN cord-015021-pol2qm74 4782 2 basal basal NN cord-015021-pol2qm74 4783 1 Ca ca NN cord-015021-pol2qm74 4783 2 2 2 CD cord-015021-pol2qm74 4783 3 + + CC cord-015021-pol2qm74 4783 4 concentration concentration NN cord-015021-pol2qm74 4783 5 remained remain VBD cord-015021-pol2qm74 4783 6 unchanged unchanged JJ cord-015021-pol2qm74 4783 7 ( ( -LRB- cord-015021-pol2qm74 4783 8 day day NN cord-015021-pol2qm74 4783 9 4 4 CD cord-015021-pol2qm74 4783 10 : : : cord-015021-pol2qm74 4783 11 68+_17 68+_17 CD cord-015021-pol2qm74 4783 12 , , , cord-015021-pol2qm74 4783 13 day day NN cord-015021-pol2qm74 4783 14 7 7 CD cord-015021-pol2qm74 4783 15 : : : cord-015021-pol2qm74 4783 16 68+_15 68+_15 CD cord-015021-pol2qm74 4783 17 ) ) -RRB- cord-015021-pol2qm74 4783 18 , , , cord-015021-pol2qm74 4783 19 FMLP FMLP NNP cord-015021-pol2qm74 4783 20 - - HYPH cord-015021-pol2qm74 4783 21 stimulated stimulate VBN cord-015021-pol2qm74 4783 22 cytosolic cytosolic JJ cord-015021-pol2qm74 4784 1 Ca ca NN cord-015021-pol2qm74 4784 2 2 2 CD cord-015021-pol2qm74 4784 3 + + CD cord-015021-pol2qm74 4785 1 mobilization mobilization NN cord-015021-pol2qm74 4785 2 increased increase VBD cord-015021-pol2qm74 4785 3 at at IN cord-015021-pol2qm74 4785 4 day day NN cord-015021-pol2qm74 4785 5 7 7 CD cord-015021-pol2qm74 4785 6 ( ( -LRB- cord-015021-pol2qm74 4785 7 day day NN cord-015021-pol2qm74 4785 8 4 4 CD cord-015021-pol2qm74 4785 9 : : : cord-015021-pol2qm74 4785 10 457 457 CD cord-015021-pol2qm74 4785 11 + + SYM cord-015021-pol2qm74 4785 12 89 89 CD cord-015021-pol2qm74 4785 13 , , , cord-015021-pol2qm74 4785 14 day day NN cord-015021-pol2qm74 4785 15 7 7 CD cord-015021-pol2qm74 4785 16 : : SYM cord-015021-pol2qm74 4785 17 11084410 11084410 CD cord-015021-pol2qm74 4785 18 , , , cord-015021-pol2qm74 4785 19 day day NN cord-015021-pol2qm74 4785 20 9 9 CD cord-015021-pol2qm74 4785 21 : : : cord-015021-pol2qm74 4785 22 670 670 CD cord-015021-pol2qm74 4785 23 + + SYM cord-015021-pol2qm74 4785 24 262 262 CD cord-015021-pol2qm74 4785 25 ) ) -RRB- cord-015021-pol2qm74 4785 26 . . . cord-015021-pol2qm74 4786 1 Conclusion conclusion NN cord-015021-pol2qm74 4786 2 . . . cord-015021-pol2qm74 4787 1 The the DT cord-015021-pol2qm74 4787 2 present present JJ cord-015021-pol2qm74 4787 3 study study NN cord-015021-pol2qm74 4787 4 in in IN cord-015021-pol2qm74 4787 5 polytraumatized polytraumatize VBN cord-015021-pol2qm74 4787 6 patients patient NNS cord-015021-pol2qm74 4787 7 shows show VBZ cord-015021-pol2qm74 4787 8 , , , cord-015021-pol2qm74 4787 9 that that IN cord-015021-pol2qm74 4787 10 seven seven CD cord-015021-pol2qm74 4787 11 days day NNS cord-015021-pol2qm74 4787 12 after after IN cord-015021-pol2qm74 4787 13 injury injury NN cord-015021-pol2qm74 4787 14 the the DT cord-015021-pol2qm74 4787 15 agonist agonist NN cord-015021-pol2qm74 4787 16 - - HYPH cord-015021-pol2qm74 4787 17 induced induce VBN cord-015021-pol2qm74 4787 18 PMNL PMNL NNP cord-015021-pol2qm74 4788 1 Ca ca NN cord-015021-pol2qm74 4788 2 2 2 CD cord-015021-pol2qm74 4788 3 + + CC cord-015021-pol2qm74 4788 4 mobilization mobilization NN cord-015021-pol2qm74 4788 5 is be VBZ cord-015021-pol2qm74 4788 6 significantly significantly RB cord-015021-pol2qm74 4788 7 enhanced enhance VBN cord-015021-pol2qm74 4788 8 . . . cord-015021-pol2qm74 4789 1 At at IN cord-015021-pol2qm74 4789 2 the the DT cord-015021-pol2qm74 4789 3 same same JJ cord-015021-pol2qm74 4789 4 time time NN cord-015021-pol2qm74 4789 5 , , , cord-015021-pol2qm74 4789 6 PMNL PMNL NNP cord-015021-pol2qm74 4789 7 - - HYPH cord-015021-pol2qm74 4789 8 oxygen oxygen NN cord-015021-pol2qm74 4789 9 free free JJ cord-015021-pol2qm74 4789 10 radical radical JJ cord-015021-pol2qm74 4789 11 release release NN cord-015021-pol2qm74 4789 12 and and CC cord-015021-pol2qm74 4789 13 phagocytotic phagocytotic JJ cord-015021-pol2qm74 4789 14 activity activity NN cord-015021-pol2qm74 4789 15 , , , cord-015021-pol2qm74 4789 16 systemic systemic JJ cord-015021-pol2qm74 4789 17 fever fever NN cord-015021-pol2qm74 4789 18 response response NN cord-015021-pol2qm74 4789 19 and and CC cord-015021-pol2qm74 4789 20 lactate lactate NN cord-015021-pol2qm74 4789 21 concentrations concentration NNS cord-015021-pol2qm74 4789 22 were be VBD cord-015021-pol2qm74 4789 23 maximal maximal JJ cord-015021-pol2qm74 4789 24 . . . cord-015021-pol2qm74 4790 1 These these DT cord-015021-pol2qm74 4790 2 observations observation NNS cord-015021-pol2qm74 4790 3 were be VBD cord-015021-pol2qm74 4790 4 accompanied accompany VBN cord-015021-pol2qm74 4790 5 by by IN cord-015021-pol2qm74 4790 6 post post JJ cord-015021-pol2qm74 4790 7 - - JJ cord-015021-pol2qm74 4790 8 tranmatic tranmatic JJ cord-015021-pol2qm74 4790 9 respiratory respiratory JJ cord-015021-pol2qm74 4790 10 failure failure NN cord-015021-pol2qm74 4790 11 and and CC cord-015021-pol2qm74 4790 12 in in IN cord-015021-pol2qm74 4790 13 some some DT cord-015021-pol2qm74 4790 14 patients patient NNS cord-015021-pol2qm74 4790 15 by by IN cord-015021-pol2qm74 4790 16 clinical clinical JJ cord-015021-pol2qm74 4790 17 signs sign NNS cord-015021-pol2qm74 4790 18 of of IN cord-015021-pol2qm74 4790 19 multiple multiple JJ cord-015021-pol2qm74 4790 20 organ organ NN cord-015021-pol2qm74 4790 21 failure failure NN cord-015021-pol2qm74 4790 22 . . . cord-015021-pol2qm74 4791 1 Preliminary preliminary JJ cord-015021-pol2qm74 4791 2 data datum NNS cord-015021-pol2qm74 4791 3 from from IN cord-015021-pol2qm74 4791 4 an an DT cord-015021-pol2qm74 4791 5 ongoing ongoing JJ cord-015021-pol2qm74 4791 6 study study NN cord-015021-pol2qm74 4791 7 using use VBG cord-015021-pol2qm74 4791 8 HES HES NNP cord-015021-pol2qm74 4791 9 - - HYPH cord-015021-pol2qm74 4791 10 and and CC cord-015021-pol2qm74 4791 11 dextran dextran NN cord-015021-pol2qm74 4791 12 - - HYPH cord-015021-pol2qm74 4791 13 infusions infusion NNS cord-015021-pol2qm74 4791 14 in in IN cord-015021-pol2qm74 4791 15 these these DT cord-015021-pol2qm74 4791 16 patients patient NNS cord-015021-pol2qm74 4791 17 show show VBP cord-015021-pol2qm74 4791 18 attenuation attenuation NN cord-015021-pol2qm74 4791 19 of of IN cord-015021-pol2qm74 4791 20 this this DT cord-015021-pol2qm74 4791 21 inflammatory inflammatory JJ cord-015021-pol2qm74 4791 22 response response NN cord-015021-pol2qm74 4791 23 . . . cord-015021-pol2qm74 4792 1 Stefan Stefan NNP cord-015021-pol2qm74 4792 2 Rose Rose NNP cord-015021-pol2qm74 4792 3 , , , cord-015021-pol2qm74 4792 4 M.D. M.D. NNP cord-015021-pol2qm74 4792 5 , , , cord-015021-pol2qm74 4792 6 Trauma Trauma NNP cord-015021-pol2qm74 4792 7 Surgery Surgery NNP cord-015021-pol2qm74 4792 8 , , , cord-015021-pol2qm74 4792 9 Univ Univ NNP cord-015021-pol2qm74 4792 10 . . NNP cord-015021-pol2qm74 4792 11 of of IN cord-015021-pol2qm74 4792 12 Saarland Saarland NNP cord-015021-pol2qm74 4792 13 , , , cord-015021-pol2qm74 4792 14 66421 66421 CD cord-015021-pol2qm74 4793 1 Homburg Homburg NNP cord-015021-pol2qm74 4793 2 / / SYM cord-015021-pol2qm74 4793 3 Saar Saar NNP cord-015021-pol2qm74 4793 4 1Donnelly 1Donnelly NNP cord-015021-pol2qm74 4793 5 SC SC NNP cord-015021-pol2qm74 4793 6 , , , cord-015021-pol2qm74 4793 7 1Haslett 1Haslett NNP cord-015021-pol2qm74 4793 8 C C NNP cord-015021-pol2qm74 4793 9 , , , cord-015021-pol2qm74 4793 10 1Dransfield 1dransfield JJ cord-015021-pol2qm74 4793 11 I -PRON- PRP cord-015021-pol2qm74 4793 12 , , , cord-015021-pol2qm74 4793 13 2Robertson 2Robertson NNP cord-015021-pol2qm74 4793 14 CE CE NNP cord-015021-pol2qm74 4793 15 , , , cord-015021-pol2qm74 4793 16 3Grant 3grant JJ cord-015021-pol2qm74 4793 17 IS be VBZ cord-015021-pol2qm74 4793 18 , , , cord-015021-pol2qm74 4793 19 4Carter 4Carter NNP cord-015021-pol2qm74 4793 20 C C NNP cord-015021-pol2qm74 4793 21 , , , cord-015021-pol2qm74 4793 22 4Ross 4ross CD cord-015021-pol2qm74 4793 23 JA JA NNP cord-015021-pol2qm74 4793 24 , , , cord-015021-pol2qm74 4793 25 5Tedder 5Tedder NNP cord-015021-pol2qm74 4793 26 TF TF NNP cord-015021-pol2qm74 4793 27 . . . cord-015021-pol2qm74 4794 1 1Dept 1Dept NNP cord-015021-pol2qm74 4794 2 's 's POS cord-015021-pol2qm74 4794 3 of of IN cord-015021-pol2qm74 4794 4 Respiratory Respiratory NNP cord-015021-pol2qm74 4794 5 Medicine Medicine NNP cord-015021-pol2qm74 4794 6 , , , cord-015021-pol2qm74 4794 7 2Accident 2Accident NNP cord-015021-pol2qm74 4794 8 & & CC cord-015021-pol2qm74 4794 9 Emergency Emergency NNP cord-015021-pol2qm74 4794 10 , , , cord-015021-pol2qm74 4794 11 3Intensive 3Intensive NNP cord-015021-pol2qm74 4794 12 Care Care NNP cord-015021-pol2qm74 4794 13 , , , cord-015021-pol2qm74 4794 14 4Surgery 4surgery CD cord-015021-pol2qm74 4794 15 , , , cord-015021-pol2qm74 4794 16 University University NNP cord-015021-pol2qm74 4794 17 of of IN cord-015021-pol2qm74 4794 18 Edinburgh Edinburgh NNP cord-015021-pol2qm74 4794 19 , , , cord-015021-pol2qm74 4794 20 Scotland Scotland NNP cord-015021-pol2qm74 4794 21 and and CC cord-015021-pol2qm74 4794 22 5Dept 5Dept NNP cord-015021-pol2qm74 4794 23 . . . cord-015021-pol2qm74 4795 1 Tumor Tumor NNP cord-015021-pol2qm74 4795 2 Immunology Immunology NNP cord-015021-pol2qm74 4795 3 , , , cord-015021-pol2qm74 4795 4 Dana Dana NNP cord-015021-pol2qm74 4795 5 Farber Farber NNP cord-015021-pol2qm74 4795 6 Cancer Cancer NNP cord-015021-pol2qm74 4795 7 Institute Institute NNP cord-015021-pol2qm74 4795 8 , , , cord-015021-pol2qm74 4795 9 Boston Boston NNP cord-015021-pol2qm74 4795 10 . . . cord-015021-pol2qm74 4796 1 The the DT cord-015021-pol2qm74 4796 2 selectins selectin NNS cord-015021-pol2qm74 4796 3 are be VBP cord-015021-pol2qm74 4796 4 a a DT cord-015021-pol2qm74 4796 5 family family NN cord-015021-pol2qm74 4796 6 of of IN cord-015021-pol2qm74 4796 7 adhesion adhesion NN cord-015021-pol2qm74 4796 8 molecules molecule NNS cord-015021-pol2qm74 4797 1 ( ( -LRB- cord-015021-pol2qm74 4797 2 L L NNP cord-015021-pol2qm74 4797 3 - - HYPH cord-015021-pol2qm74 4797 4 selectin selectin NNP cord-015021-pol2qm74 4797 5 , , , cord-015021-pol2qm74 4797 6 E e NN cord-015021-pol2qm74 4797 7 - - NN cord-015021-pol2qm74 4797 8 selectin selectin JJ cord-015021-pol2qm74 4797 9 , , , cord-015021-pol2qm74 4797 10 Pselectin Pselectin NNP cord-015021-pol2qm74 4797 11 ) ) -RRB- cord-015021-pol2qm74 4797 12 , , , cord-015021-pol2qm74 4797 13 all all DT cord-015021-pol2qm74 4797 14 of of IN cord-015021-pol2qm74 4797 15 whom whom WP cord-015021-pol2qm74 4797 16 are be VBP cord-015021-pol2qm74 4797 17 implicated implicate VBN cord-015021-pol2qm74 4797 18 in in IN cord-015021-pol2qm74 4797 19 inflammatory inflammatory JJ cord-015021-pol2qm74 4797 20 cell cell NN cord-015021-pol2qm74 4797 21 transendothelial transendothelial NN cord-015021-pol2qm74 4797 22 migration migration NN cord-015021-pol2qm74 4797 23 . . . cord-015021-pol2qm74 4798 1 They -PRON- PRP cord-015021-pol2qm74 4798 2 , , , cord-015021-pol2qm74 4798 3 as as IN cord-015021-pol2qm74 4798 4 a a DT cord-015021-pol2qm74 4798 5 family family NN cord-015021-pol2qm74 4798 6 can can MD cord-015021-pol2qm74 4798 7 be be VB cord-015021-pol2qm74 4798 8 proteolytieally proteolytieally RB cord-015021-pol2qm74 4798 9 cleaved cleave VBN cord-015021-pol2qm74 4798 10 from from IN cord-015021-pol2qm74 4798 11 their -PRON- PRP$ cord-015021-pol2qm74 4798 12 parent parent NN cord-015021-pol2qm74 4798 13 cell cell NN cord-015021-pol2qm74 4798 14 and and CC cord-015021-pol2qm74 4798 15 exist exist VBP cord-015021-pol2qm74 4798 16 in in IN cord-015021-pol2qm74 4798 17 a a DT cord-015021-pol2qm74 4798 18 soluble soluble JJ cord-015021-pol2qm74 4798 19 form form NN cord-015021-pol2qm74 4798 20 within within IN cord-015021-pol2qm74 4798 21 the the DT cord-015021-pol2qm74 4798 22 circulation circulation NN cord-015021-pol2qm74 4798 23 . . . cord-015021-pol2qm74 4799 1 ARDS ARDS NNP cord-015021-pol2qm74 4799 2 is be VBZ cord-015021-pol2qm74 4799 3 a a DT cord-015021-pol2qm74 4799 4 disease disease NN cord-015021-pol2qm74 4799 5 state state NN cord-015021-pol2qm74 4799 6 in in IN cord-015021-pol2qm74 4799 7 whic whic JJ cord-015021-pol2qm74 4799 8 neutrophils neutrophil NNS cord-015021-pol2qm74 4799 9 and and CC cord-015021-pol2qm74 4799 10 neutrophil neutrophil NN cord-015021-pol2qm74 4799 11 transendotheliat transendotheliat NNP cord-015021-pol2qm74 4799 12 migration migration NN cord-015021-pol2qm74 4799 13 have have VBP cord-015021-pol2qm74 4799 14 been be VBN cord-015021-pol2qm74 4799 15 implicated implicate VBN cord-015021-pol2qm74 4799 16 . . . cord-015021-pol2qm74 4800 1 In in IN cord-015021-pol2qm74 4800 2 this this DT cord-015021-pol2qm74 4800 3 study study NN cord-015021-pol2qm74 4800 4 we -PRON- PRP cord-015021-pol2qm74 4800 5 wished wish VBD cord-015021-pol2qm74 4800 6 to to TO cord-015021-pol2qm74 4800 7 investigate investigate VB cord-015021-pol2qm74 4800 8 whether whether IN cord-015021-pol2qm74 4800 9 the the DT cord-015021-pol2qm74 4800 10 levels level NNS cord-015021-pol2qm74 4800 11 of of IN cord-015021-pol2qm74 4800 12 these these DT cord-015021-pol2qm74 4800 13 circulating circulate VBG cord-015021-pol2qm74 4800 14 soluble soluble JJ cord-015021-pol2qm74 4800 15 receptors receptor NNS cord-015021-pol2qm74 4800 16 from from IN cord-015021-pol2qm74 4800 17 patients patient NNS cord-015021-pol2qm74 4800 18 at at IN cord-015021-pol2qm74 4800 19 - - HYPH cord-015021-pol2qm74 4800 20 risk risk NN cord-015021-pol2qm74 4800 21 of of IN cord-015021-pol2qm74 4800 22 ARDS ARDS NNP cord-015021-pol2qm74 4800 23 at at IN cord-015021-pol2qm74 4800 24 initial initial JJ cord-015021-pol2qm74 4800 25 hospital hospital NN cord-015021-pol2qm74 4800 26 presentation presentation NN cord-015021-pol2qm74 4800 27 , , , cord-015021-pol2qm74 4800 28 correlated correlate VBN cord-015021-pol2qm74 4800 29 with with IN cord-015021-pol2qm74 4800 30 subsequent subsequent JJ cord-015021-pol2qm74 4800 31 ARDS ARDS NNP cord-015021-pol2qm74 4800 32 progression progression NN cord-015021-pol2qm74 4800 33 . . . cord-015021-pol2qm74 4801 1 Eighty eighty CD cord-015021-pol2qm74 4801 2 - - HYPH cord-015021-pol2qm74 4801 3 two two CD cord-015021-pol2qm74 4801 4 patients patient NNS cord-015021-pol2qm74 4801 5 were be VBD cord-015021-pol2qm74 4801 6 enrolled enrol VBN cord-015021-pol2qm74 4801 7 ( ( -LRB- cord-015021-pol2qm74 4801 8 pancreatitis pancreatitis NNP cord-015021-pol2qm74 4801 9 ( ( -LRB- cord-015021-pol2qm74 4801 10 n=19 n=19 NNP cord-015021-pol2qm74 4801 11 ) ) -RRB- cord-015021-pol2qm74 4801 12 , , , cord-015021-pol2qm74 4801 13 perforated perforated JJ cord-015021-pol2qm74 4801 14 bowel bowel NN cord-015021-pol2qm74 4801 15 ( ( -LRB- cord-015021-pol2qm74 4801 16 n=12 n=12 NNP cord-015021-pol2qm74 4801 17 ) ) -RRB- cord-015021-pol2qm74 4801 18 , , , cord-015021-pol2qm74 4801 19 and and CC cord-015021-pol2qm74 4801 20 multiple multiple JJ cord-015021-pol2qm74 4801 21 trauma trauma NN cord-015021-pol2qm74 4801 22 ( ( -LRB- cord-015021-pol2qm74 4801 23 n=51 n=51 NNP cord-015021-pol2qm74 4801 24 ) ) -RRB- cord-015021-pol2qm74 4801 25 ) ) -RRB- cord-015021-pol2qm74 4801 26 , , , cord-015021-pol2qm74 4801 27 of of IN cord-015021-pol2qm74 4801 28 whom whom WP cord-015021-pol2qm74 4801 29 14 14 CD cord-015021-pol2qm74 4801 30 progressed progress VBD cord-015021-pol2qm74 4801 31 to to IN cord-015021-pol2qm74 4801 32 ARDS ARDS NNP cord-015021-pol2qm74 4801 33 . . . cord-015021-pol2qm74 4802 1 Assays assay NNS cord-015021-pol2qm74 4802 2 for for IN cord-015021-pol2qm74 4802 3 soluble soluble JJ cord-015021-pol2qm74 4802 4 L l NN cord-015021-pol2qm74 4802 5 , , , cord-015021-pol2qm74 4802 6 P p NN cord-015021-pol2qm74 4802 7 & & CC cord-015021-pol2qm74 4802 8 E E NNP cord-015021-pol2qm74 4802 9 - - NN cord-015021-pol2qm74 4802 10 selectin selectin NNP cord-015021-pol2qm74 4802 11 were be VBD cord-015021-pol2qm74 4802 12 performed perform VBN cord-015021-pol2qm74 4802 13 on on IN cord-015021-pol2qm74 4802 14 collected collect VBN cord-015021-pol2qm74 4802 15 plasma plasma NN cord-015021-pol2qm74 4802 16 samples sample NNS cord-015021-pol2qm74 4802 17 via via IN cord-015021-pol2qm74 4802 18 a a DT cord-015021-pol2qm74 4802 19 sandwich sandwich NN cord-015021-pol2qm74 4802 20 ELISA ELISA NNP cord-015021-pol2qm74 4802 21 . . . cord-015021-pol2qm74 4803 1 ( ( -LRB- cord-015021-pol2qm74 4803 2 NS NS NNP cord-015021-pol2qm74 4803 3 = = NFP cord-015021-pol2qm74 4803 4 Not not RB cord-015021-pol2qm74 4803 5 significant significant JJ cord-015021-pol2qm74 4803 6 , , , cord-015021-pol2qm74 4804 1 * * NFP cord-015021-pol2qm74 4804 2 * * NFP cord-015021-pol2qm74 4804 3 * * NFP cord-015021-pol2qm74 4804 4 * * NFP cord-015021-pol2qm74 4804 5 = = SYM cord-015021-pol2qm74 4804 6 p p NN cord-015021-pol2qm74 4804 7 < < XX cord-015021-pol2qm74 4804 8 O.0001 O.0001 NNP cord-015021-pol2qm74 4804 9 ) ) -RRB- cord-015021-pol2qm74 4805 1 We -PRON- PRP cord-015021-pol2qm74 4805 2 have have VBP cord-015021-pol2qm74 4805 3 found find VBN cord-015021-pol2qm74 4805 4 a a DT cord-015021-pol2qm74 4805 5 highly highly RB cord-015021-pol2qm74 4805 6 significant significant JJ cord-015021-pol2qm74 4805 7 inverse inverse JJ cord-015021-pol2qm74 4805 8 correlation correlation NN cord-015021-pol2qm74 4805 9 between between IN cord-015021-pol2qm74 4805 10 a a DT cord-015021-pol2qm74 4805 11 low low JJ cord-015021-pol2qm74 4805 12 circulating circulate VBG cord-015021-pol2qm74 4805 13 soluble soluble JJ cord-015021-pol2qm74 4805 14 L l NN cord-015021-pol2qm74 4805 15 - - HYPH cord-015021-pol2qm74 4805 16 selectin selectin NNP cord-015021-pol2qm74 4805 17 ( ( -LRB- cord-015021-pol2qm74 4805 18 and and CC cord-015021-pol2qm74 4805 19 not not RB cord-015021-pol2qm74 4805 20 soluble soluble JJ cord-015021-pol2qm74 4805 21 E e NN cord-015021-pol2qm74 4805 22 & & CC cord-015021-pol2qm74 4805 23 P P NNP cord-015021-pol2qm74 4805 24 - - HYPH cord-015021-pol2qm74 4805 25 selectin selectin NNP cord-015021-pol2qm74 4805 26 ) ) -RRB- cord-015021-pol2qm74 4805 27 and and CC cord-015021-pol2qm74 4805 28 subsequent subsequent JJ cord-015021-pol2qm74 4805 29 ARDS ARDS NNP cord-015021-pol2qm74 4805 30 . . . cord-015021-pol2qm74 4806 1 These these DT cord-015021-pol2qm74 4806 2 results result NNS cord-015021-pol2qm74 4806 3 further far RBR cord-015021-pol2qm74 4806 4 our -PRON- PRP$ cord-015021-pol2qm74 4806 5 understanding understanding NN cord-015021-pol2qm74 4806 6 of of IN cord-015021-pol2qm74 4806 7 neutrophilendothelial neutrophilendothelial JJ cord-015021-pol2qm74 4806 8 interactions interaction NNS cord-015021-pol2qm74 4806 9 in in IN cord-015021-pol2qm74 4806 10 the the DT cord-015021-pol2qm74 4806 11 early early JJ cord-015021-pol2qm74 4806 12 stages stage NNS cord-015021-pol2qm74 4806 13 of of IN cord-015021-pol2qm74 4806 14 ARDS ARDS NNP cord-015021-pol2qm74 4806 15 pathogenesis pathogenesis NN cord-015021-pol2qm74 4806 16 and and CC cord-015021-pol2qm74 4806 17 offer offer VBP cord-015021-pol2qm74 4806 18 the the DT cord-015021-pol2qm74 4806 19 promise promise NN cord-015021-pol2qm74 4806 20 of of IN cord-015021-pol2qm74 4806 21 sL sL NNS cord-015021-pol2qm74 4806 22 - - : cord-015021-pol2qm74 4806 23 selectin selectin NN cord-015021-pol2qm74 4806 24 in in IN cord-015021-pol2qm74 4806 25 combination combination NN cord-015021-pol2qm74 4806 26 with with IN cord-015021-pol2qm74 4806 27 other other JJ cord-015021-pol2qm74 4806 28 markers marker NNS cord-015021-pol2qm74 4806 29 of of IN cord-015021-pol2qm74 4806 30 inflammatory inflammatory JJ cord-015021-pol2qm74 4806 31 events event NNS cord-015021-pol2qm74 4806 32 being be VBG cord-015021-pol2qm74 4806 33 used use VBN cord-015021-pol2qm74 4806 34 to to TO cord-015021-pol2qm74 4806 35 identify identify VB cord-015021-pol2qm74 4806 36 individuals individual NNS cord-015021-pol2qm74 4806 37 at at IN cord-015021-pol2qm74 4806 38 particularly particularly RB cord-015021-pol2qm74 4806 39 high high JJ cord-015021-pol2qm74 4806 40 risk risk NN cord-015021-pol2qm74 4806 41 of of IN cord-015021-pol2qm74 4806 42 ARDS ARDS NNP cord-015021-pol2qm74 4806 43 progression progression NN cord-015021-pol2qm74 4806 44 on on IN cord-015021-pol2qm74 4806 45 initial initial JJ cord-015021-pol2qm74 4806 46 hospital hospital NN cord-015021-pol2qm74 4806 47 presentation presentation NN cord-015021-pol2qm74 4806 48 . . . cord-015021-pol2qm74 4807 1 It -PRON- PRP cord-015021-pol2qm74 4807 2 has have VBZ cord-015021-pol2qm74 4807 3 been be VBN cord-015021-pol2qm74 4807 4 suggested suggest VBN cord-015021-pol2qm74 4807 5 that that IN cord-015021-pol2qm74 4807 6 polymorphonuclear polymorphonuclear NNP cord-015021-pol2qm74 4807 7 leukocytes leukocyte NNS cord-015021-pol2qm74 4807 8 aggregate aggregate VBP cord-015021-pol2qm74 4807 9 in in IN cord-015021-pol2qm74 4807 10 the the DT cord-015021-pol2qm74 4807 11 lung lung NN cord-015021-pol2qm74 4807 12 capillaries capillary NNS cord-015021-pol2qm74 4807 13 of of IN cord-015021-pol2qm74 4807 14 patients patient NNS cord-015021-pol2qm74 4807 15 developing develop VBG cord-015021-pol2qm74 4807 16 the the DT cord-015021-pol2qm74 4807 17 adult adult NN cord-015021-pol2qm74 4807 18 respiratory respiratory JJ cord-015021-pol2qm74 4807 19 distress distress NN cord-015021-pol2qm74 4807 20 syndrome syndrome NN cord-015021-pol2qm74 4807 21 ( ( -LRB- cord-015021-pol2qm74 4807 22 ARDS ARDS NNP cord-015021-pol2qm74 4807 23 ) ) -RRB- cord-015021-pol2qm74 4807 24 and and CC cord-015021-pol2qm74 4807 25 account account VB cord-015021-pol2qm74 4807 26 for for IN cord-015021-pol2qm74 4807 27 the the DT cord-015021-pol2qm74 4807 28 endothelial endothelial JJ cord-015021-pol2qm74 4807 29 damage damage NN cord-015021-pol2qm74 4807 30 while while IN cord-015021-pol2qm74 4807 31 releasing release VBG cord-015021-pol2qm74 4807 32 toxic toxic JJ cord-015021-pol2qm74 4807 33 metabo metabo NNP cord-015021-pol2qm74 4807 34 - - : cord-015021-pol2qm74 4807 35 Iites Iites NNPS cord-015021-pol2qm74 4807 36 such such JJ cord-015021-pol2qm74 4807 37 as as IN cord-015021-pol2qm74 4807 38 o.a o.a NNP cord-015021-pol2qm74 4807 39 . . NNP cord-015021-pol2qm74 4807 40 free free JJ cord-015021-pol2qm74 4807 41 oxygen oxygen NN cord-015021-pol2qm74 4807 42 radicals radical NNS cord-015021-pol2qm74 4807 43 . . . cord-015021-pol2qm74 4808 1 Among among IN cord-015021-pol2qm74 4808 2 many many JJ cord-015021-pol2qm74 4808 3 antioxidants antioxidant NNS cord-015021-pol2qm74 4808 4 which which WDT cord-015021-pol2qm74 4808 5 have have VBP cord-015021-pol2qm74 4808 6 been be VBN cord-015021-pol2qm74 4808 7 investigated investigate VBN cord-015021-pol2qm74 4808 8 in in IN cord-015021-pol2qm74 4808 9 in in FW cord-015021-pol2qm74 4808 10 vitro vitro FW cord-015021-pol2qm74 4808 11 systems system NNS cord-015021-pol2qm74 4808 12 and and CC cord-015021-pol2qm74 4808 13 in in IN cord-015021-pol2qm74 4808 14 animal animal NN cord-015021-pol2qm74 4808 15 models model NNS cord-015021-pol2qm74 4808 16 , , , cord-015021-pol2qm74 4808 17 N n NN cord-015021-pol2qm74 4808 18 - - HYPH cord-015021-pol2qm74 4808 19 acetylcysteine acetylcysteine NN cord-015021-pol2qm74 4808 20 ( ( -LRB- cord-015021-pol2qm74 4808 21 NAC NAC NNP cord-015021-pol2qm74 4808 22 ) ) -RRB- cord-015021-pol2qm74 4808 23 has have VBZ cord-015021-pol2qm74 4808 24 been be VBN cord-015021-pol2qm74 4808 25 established establish VBN cord-015021-pol2qm74 4808 26 to to TO cord-015021-pol2qm74 4808 27 be be VB cord-015021-pol2qm74 4808 28 useful useful JJ cord-015021-pol2qm74 4808 29 as as IN cord-015021-pol2qm74 4808 30 a a DT cord-015021-pol2qm74 4808 31 free free JJ cord-015021-pol2qm74 4808 32 radical radical JJ cord-015021-pol2qm74 4808 33 scavenger scavenger NN cord-015021-pol2qm74 4808 34 in in IN cord-015021-pol2qm74 4808 35 vivo vivo NNP cord-015021-pol2qm74 4808 36 . . . cord-015021-pol2qm74 4809 1 To to TO cord-015021-pol2qm74 4809 2 assess assess VB cord-015021-pol2qm74 4809 3 the the DT cord-015021-pol2qm74 4809 4 influence influence NN cord-015021-pol2qm74 4809 5 of of IN cord-015021-pol2qm74 4809 6 N n NN cord-015021-pol2qm74 4809 7 - - HYPH cord-015021-pol2qm74 4809 8 acetylcysteine acetylcysteine NN cord-015021-pol2qm74 4809 9 ( ( -LRB- cord-015021-pol2qm74 4809 10 NAC NAC NNP cord-015021-pol2qm74 4809 11 ) ) -RRB- cord-015021-pol2qm74 4809 12 on on IN cord-015021-pol2qm74 4809 13 the the DT cord-015021-pol2qm74 4809 14 activation activation NN cord-015021-pol2qm74 4809 15 of of IN cord-015021-pol2qm74 4809 16 neutrophils neutrophil NNS cord-015021-pol2qm74 4809 17 in in IN cord-015021-pol2qm74 4809 18 patients patient NNS cord-015021-pol2qm74 4809 19 undergoing undergo VBG cord-015021-pol2qm74 4809 20 cardiopulmonary cardiopulmonary JJ cord-015021-pol2qm74 4809 21 bypass bypass NN cord-015021-pol2qm74 4809 22 ( ( -LRB- cord-015021-pol2qm74 4809 23 CPB CPB NNP cord-015021-pol2qm74 4809 24 ) ) -RRB- cord-015021-pol2qm74 4809 25 surgery surgery NN cord-015021-pol2qm74 4809 26 with with IN cord-015021-pol2qm74 4809 27 extracorporeal extracorporeal JJ cord-015021-pol2qm74 4809 28 circulation circulation NN cord-015021-pol2qm74 4809 29 ( ( -LRB- cord-015021-pol2qm74 4809 30 ECC ECC NNP cord-015021-pol2qm74 4809 31 ) ) -RRB- cord-015021-pol2qm74 4809 32 , , , cord-015021-pol2qm74 4809 33 we -PRON- PRP cord-015021-pol2qm74 4809 34 evaluated evaluate VBD cord-015021-pol2qm74 4809 35 the the DT cord-015021-pol2qm74 4809 36 plasma plasma NN cord-015021-pol2qm74 4809 37 levels level NNS cord-015021-pol2qm74 4809 38 of of IN cord-015021-pol2qm74 4809 39 elastase elastase NN cord-015021-pol2qm74 4809 40 and and CC cord-015021-pol2qm74 4809 41 myeloperoxidase myeloperoxidase NNP cord-015021-pol2qm74 4809 42 ( ( -LRB- cord-015021-pol2qm74 4809 43 MPO MPO NNP cord-015021-pol2qm74 4809 44 ) ) -RRB- cord-015021-pol2qm74 4809 45 throughout throughout IN cord-015021-pol2qm74 4809 46 the the DT cord-015021-pol2qm74 4809 47 operation operation NN cord-015021-pol2qm74 4809 48 and and CC cord-015021-pol2qm74 4809 49 up up IN cord-015021-pol2qm74 4809 50 to to TO cord-015021-pol2qm74 4809 51 24 24 CD cord-015021-pol2qm74 4809 52 hours hour NNS cord-015021-pol2qm74 4809 53 after after IN cord-015021-pol2qm74 4809 54 surgery surgery NN cord-015021-pol2qm74 4809 55 . . . cord-015021-pol2qm74 4810 1 Four four CD cord-015021-pol2qm74 4810 2 hours hour NNS cord-015021-pol2qm74 4810 3 after after IN cord-015021-pol2qm74 4810 4 surgery surgery NN cord-015021-pol2qm74 4810 5 also also RB cord-015021-pol2qm74 4810 6 a a DT cord-015021-pol2qm74 4810 7 bronchoalveolar bronchoalveolar NNP cord-015021-pol2qm74 4810 8 lavage lavage NN cord-015021-pol2qm74 4810 9 was be VBD cord-015021-pol2qm74 4810 10 performed perform VBN cord-015021-pol2qm74 4810 11 . . . cord-015021-pol2qm74 4811 1 A a DT cord-015021-pol2qm74 4811 2 spectrophotometric spectrophotometric JJ cord-015021-pol2qm74 4811 3 method method NN cord-015021-pol2qm74 4811 4 was be VBD cord-015021-pol2qm74 4811 5 used use VBN cord-015021-pol2qm74 4811 6 for for IN cord-015021-pol2qm74 4811 7 the the DT cord-015021-pol2qm74 4811 8 detection detection NN cord-015021-pol2qm74 4811 9 of of IN cord-015021-pol2qm74 4811 10 plasma plasma NN cord-015021-pol2qm74 4811 11 elastase elastase NN cord-015021-pol2qm74 4811 12 activity activity NN cord-015021-pol2qm74 4811 13 and and CC cord-015021-pol2qm74 4811 14 MPO MPO NNP cord-015021-pol2qm74 4811 15 levels level NNS cord-015021-pol2qm74 4811 16 were be VBD cord-015021-pol2qm74 4811 17 measured measure VBN cord-015021-pol2qm74 4811 18 using use VBG cord-015021-pol2qm74 4811 19 a a DT cord-015021-pol2qm74 4811 20 radioimmunoassay radioimmunoassay NN cord-015021-pol2qm74 4811 21 . . . cord-015021-pol2qm74 4812 1 We -PRON- PRP cord-015021-pol2qm74 4812 2 found find VBD cord-015021-pol2qm74 4812 3 that that DT cord-015021-pol2qm74 4812 4 pretreatment pretreatment NN cord-015021-pol2qm74 4812 5 with with IN cord-015021-pol2qm74 4812 6 intravenous intravenous JJ cord-015021-pol2qm74 4812 7 NAC NAC NNP cord-015021-pol2qm74 4812 8 prevented prevent VBD cord-015021-pol2qm74 4812 9 the the DT cord-015021-pol2qm74 4812 10 increase increase NN cord-015021-pol2qm74 4812 11 in in IN cord-015021-pol2qm74 4812 12 elastase elastase NN cord-015021-pol2qm74 4812 13 activity activity NN cord-015021-pol2qm74 4812 14 ( ( -LRB- cord-015021-pol2qm74 4812 15 632 632 CD cord-015021-pol2qm74 4812 16 _ _ NN cord-015021-pol2qm74 4812 17 + + SYM cord-015021-pol2qm74 4812 18 231 231 CD cord-015021-pol2qm74 4812 19 pmol pmol NN cord-015021-pol2qm74 4812 20 / / , cord-015021-pol2qm74 4812 21 I -PRON- PRP cord-015021-pol2qm74 4812 22 vs vs IN cord-015021-pol2qm74 4812 23 1666 1666 CD cord-015021-pol2qm74 4813 1 _ _ NN cord-015021-pol2qm74 4813 2 + + SYM cord-015021-pol2qm74 4813 3 187 187 CD cord-015021-pol2qm74 4813 4 ; ; : cord-015021-pol2qm74 4813 5 P p NN cord-015021-pol2qm74 4813 6 -0.027 -0.027 NNP cord-015021-pol2qm74 4813 7 ) ) -RRB- cord-015021-pol2qm74 4813 8 , , , cord-015021-pol2qm74 4813 9 but but CC cord-015021-pol2qm74 4813 10 not not RB cord-015021-pol2qm74 4813 11 the the DT cord-015021-pol2qm74 4813 12 release release NN cord-015021-pol2qm74 4813 13 of of IN cord-015021-pol2qm74 4813 14 neutrophil neutrophil NN cord-015021-pol2qm74 4813 15 related related JJ cord-015021-pol2qm74 4813 16 mediators mediator NNS cord-015021-pol2qm74 4813 17 ( ( -LRB- cord-015021-pol2qm74 4814 1 2.20 2.20 CD cord-015021-pol2qm74 4814 2 _ _ NN cord-015021-pol2qm74 4814 3 + + CC cord-015021-pol2qm74 4815 1 0.56 0.56 CD cord-015021-pol2qm74 4815 2 ng ng NNP cord-015021-pol2qm74 4815 3 / / SYM cord-015021-pol2qm74 4815 4 I -PRON- PRP cord-015021-pol2qm74 4815 5 vs vs IN cord-015021-pol2qm74 4816 1 1.80 1.80 CD cord-015021-pol2qm74 4816 2 _ _ NN cord-015021-pol2qm74 4816 3 + + SYM cord-015021-pol2qm74 4816 4 0.17 0.17 CD cord-015021-pol2qm74 4816 5 ; ; : cord-015021-pol2qm74 4816 6 P=0.63 P=0.63 NNP cord-015021-pol2qm74 4816 7 ) ) -RRB- cord-015021-pol2qm74 4816 8 . . . cord-015021-pol2qm74 4817 1 Besides besides RB cord-015021-pol2qm74 4817 2 , , , cord-015021-pol2qm74 4817 3 NAC NAC NNP cord-015021-pol2qm74 4817 4 had have VBD cord-015021-pol2qm74 4817 5 the the DT cord-015021-pol2qm74 4817 6 capability capability NN cord-015021-pol2qm74 4817 7 to to TO cord-015021-pol2qm74 4817 8 prevent prevent VB cord-015021-pol2qm74 4817 9 the the DT cord-015021-pol2qm74 4817 10 enhancement enhancement NN cord-015021-pol2qm74 4817 11 of of IN cord-015021-pol2qm74 4817 12 neutrophil neutrophil NN cord-015021-pol2qm74 4817 13 numbers number NNS cord-015021-pol2qm74 4817 14 in in IN cord-015021-pol2qm74 4817 15 lavage lavage NN cord-015021-pol2qm74 4817 16 fluid fluid NN cord-015021-pol2qm74 4817 17 as as IN cord-015021-pol2qm74 4817 18 is be VBZ cord-015021-pol2qm74 4817 19 normally normally RB cord-015021-pol2qm74 4817 20 seen see VBN cord-015021-pol2qm74 4817 21 during during IN cord-015021-pol2qm74 4817 22 CPB CPB NNP cord-015021-pol2qm74 4817 23 ( ( -LRB- cord-015021-pol2qm74 4817 24 1.4 1.4 CD cord-015021-pol2qm74 4817 25 + + SYM cord-015021-pol2qm74 4817 26 0.8 0.8 CD cord-015021-pol2qm74 4817 27 % % NN cord-015021-pol2qm74 4817 28 vs vs IN cord-015021-pol2qm74 4818 1 25.0 25.0 CD cord-015021-pol2qm74 4818 2 _ _ NN cord-015021-pol2qm74 4818 3 + + SYM cord-015021-pol2qm74 4818 4 14.3 14.3 CD cord-015021-pol2qm74 4818 5 ; ; : cord-015021-pol2qm74 4818 6 P p NN cord-015021-pol2qm74 4818 7 = = SYM cord-015021-pol2qm74 4818 8 0.04 0.04 CD cord-015021-pol2qm74 4818 9 ) ) -RRB- cord-015021-pol2qm74 4818 10 . . . cord-015021-pol2qm74 4819 1 Although although IN cord-015021-pol2qm74 4819 2 not not RB cord-015021-pol2qm74 4819 3 significant significant JJ cord-015021-pol2qm74 4819 4 , , , cord-015021-pol2qm74 4819 5 NAC NAC NNP cord-015021-pol2qm74 4819 6 prevented prevent VBD cord-015021-pol2qm74 4819 7 also also RB cord-015021-pol2qm74 4819 8 the the DT cord-015021-pol2qm74 4819 9 increase increase NN cord-015021-pol2qm74 4819 10 in in IN cord-015021-pol2qm74 4819 11 elastase elastase NN cord-015021-pol2qm74 4819 12 levels level NNS cord-015021-pol2qm74 4819 13 in in IN cord-015021-pol2qm74 4819 14 lavage lavage NN cord-015021-pol2qm74 4819 15 fluid fluid NN cord-015021-pol2qm74 4819 16 ( ( -LRB- cord-015021-pol2qm74 4819 17 19.0 19.0 CD cord-015021-pol2qm74 4819 18 + + SYM cord-015021-pol2qm74 4819 19 18.5 18.5 CD cord-015021-pol2qm74 4819 20 pmol pmol NNP cord-015021-pol2qm74 4819 21 / / , cord-015021-pol2qm74 4819 22 I -PRON- PRP cord-015021-pol2qm74 4819 23 vs vs IN cord-015021-pol2qm74 4819 24 172.7 172.7 CD cord-015021-pol2qm74 4819 25 + + SYM cord-015021-pol2qm74 4819 26 101.4 101.4 CD cord-015021-pol2qm74 4819 27 ; ; : cord-015021-pol2qm74 4819 28 P p NN cord-015021-pol2qm74 4819 29 = = SYM cord-015021-pol2qm74 4819 30 0.12 0.12 CD cord-015021-pol2qm74 4819 31 ) ) -RRB- cord-015021-pol2qm74 4819 32 . . . cord-015021-pol2qm74 4820 1 It -PRON- PRP cord-015021-pol2qm74 4820 2 is be VBZ cord-015021-pol2qm74 4820 3 concluded conclude VBN cord-015021-pol2qm74 4820 4 that that IN cord-015021-pol2qm74 4820 5 NAC NAC NNP cord-015021-pol2qm74 4820 6 is be VBZ cord-015021-pol2qm74 4820 7 able able JJ cord-015021-pol2qm74 4820 8 to to TO cord-015021-pol2qm74 4820 9 protect protect VB cord-015021-pol2qm74 4820 10 against against IN cord-015021-pol2qm74 4820 11 the the DT cord-015021-pol2qm74 4820 12 inactivation inactivation NN cord-015021-pol2qm74 4820 13 of of IN cord-015021-pol2qm74 4820 14 a a DT cord-015021-pol2qm74 4820 15 1-proteinase 1-proteinase CD cord-015021-pol2qm74 4820 16 inhibitor inhibitor NN cord-015021-pol2qm74 4820 17 , , , cord-015021-pol2qm74 4820 18 the the DT cord-015021-pol2qm74 4820 19 main main JJ cord-015021-pol2qm74 4820 20 inhibitor inhibitor NN cord-015021-pol2qm74 4820 21 of of IN cord-015021-pol2qm74 4820 22 elastase elastase NN cord-015021-pol2qm74 4820 23 activity activity NN cord-015021-pol2qm74 4820 24 , , , cord-015021-pol2qm74 4820 25 and and CC cord-015021-pol2qm74 4820 26 that that IN cord-015021-pol2qm74 4820 27 NAC NAC NNP cord-015021-pol2qm74 4820 28 interferes interfere VBZ cord-015021-pol2qm74 4820 29 with with IN cord-015021-pol2qm74 4820 30 adhesion adhesion NN cord-015021-pol2qm74 4820 31 and and CC cord-015021-pol2qm74 4820 32 migration migration NN cord-015021-pol2qm74 4820 33 of of IN cord-015021-pol2qm74 4820 34 neutrophils neutrophil NNS cord-015021-pol2qm74 4820 35 . . . cord-015021-pol2qm74 4821 1 Therefore therefore RB cord-015021-pol2qm74 4821 2 NAC NAC NNP cord-015021-pol2qm74 4821 3 may may MD cord-015021-pol2qm74 4821 4 be be VB cord-015021-pol2qm74 4821 5 useful useful JJ cord-015021-pol2qm74 4821 6 in in IN cord-015021-pol2qm74 4821 7 the the DT cord-015021-pol2qm74 4821 8 prevention prevention NN cord-015021-pol2qm74 4821 9 of of IN cord-015021-pol2qm74 4821 10 tissue tissue NN cord-015021-pol2qm74 4821 11 damage damage NN cord-015021-pol2qm74 4821 12 . . . cord-015021-pol2qm74 4822 1 This this DT cord-015021-pol2qm74 4822 2 study study NN cord-015021-pol2qm74 4822 3 is be VBZ cord-015021-pol2qm74 4822 4 supported support VBN cord-015021-pol2qm74 4822 5 by by IN cord-015021-pol2qm74 4822 6 Inpharzam Inpharzam NNP cord-015021-pol2qm74 4822 7 Belgium Belgium NNP cord-015021-pol2qm74 4822 8 . . . cord-015021-pol2qm74 4823 1 Sodium sodium NN cord-015021-pol2qm74 4823 2 nitroprnsside nitroprnsside NN cord-015021-pol2qm74 4823 3 ( ( -LRB- cord-015021-pol2qm74 4823 4 SNP SNP NNP cord-015021-pol2qm74 4823 5 ) ) -RRB- cord-015021-pol2qm74 4823 6 has have VBZ cord-015021-pol2qm74 4823 7 previously previously RB cord-015021-pol2qm74 4823 8 been be VBN cord-015021-pol2qm74 4823 9 shown show VBN cord-015021-pol2qm74 4823 10 to to TO cord-015021-pol2qm74 4823 11 attenuate attenuate VB cord-015021-pol2qm74 4823 12 the the DT cord-015021-pol2qm74 4823 13 neutrophil neutrophil NN cord-015021-pol2qm74 4823 14 induced induce VBN cord-015021-pol2qm74 4823 15 lung lung NN cord-015021-pol2qm74 4823 16 injury injury NN cord-015021-pol2qm74 4823 17 associated associate VBN cord-015021-pol2qm74 4823 18 with with IN cord-015021-pol2qm74 4823 19 limb limb NN cord-015021-pol2qm74 4823 20 ischaemia ischaemia NN cord-015021-pol2qm74 4823 21 and and CC cord-015021-pol2qm74 4823 22 repeffusion repeffusion NN cord-015021-pol2qm74 4823 23 . . . cord-015021-pol2qm74 4824 1 Glyceryl Glyceryl NNP cord-015021-pol2qm74 4824 2 Trinitrate Trinitrate NNP cord-015021-pol2qm74 4824 3 ( ( -LRB- cord-015021-pol2qm74 4824 4 GTN GTN NNP cord-015021-pol2qm74 4824 5 ) ) -RRB- cord-015021-pol2qm74 4824 6 , , , cord-015021-pol2qm74 4824 7 already already RB cord-015021-pol2qm74 4824 8 widely widely RB cord-015021-pol2qm74 4824 9 used use VBN cord-015021-pol2qm74 4824 10 in in IN cord-015021-pol2qm74 4824 11 aortic aortic JJ cord-015021-pol2qm74 4824 12 surgery surgery NN cord-015021-pol2qm74 4824 13 , , , cord-015021-pol2qm74 4824 14 also also RB cord-015021-pol2qm74 4824 15 increases increase VBZ cord-015021-pol2qm74 4824 16 nitric nitric JJ cord-015021-pol2qm74 4824 17 oxide oxide NN cord-015021-pol2qm74 4824 18 but but CC cord-015021-pol2qm74 4824 19 has have VBZ cord-015021-pol2qm74 4824 20 a a DT cord-015021-pol2qm74 4824 21 less less RBR cord-015021-pol2qm74 4824 22 marked marked JJ cord-015021-pol2qm74 4824 23 splanchnic splanchnic JJ cord-015021-pol2qm74 4824 24 " " `` cord-015021-pol2qm74 4824 25 steal steal VB cord-015021-pol2qm74 4824 26 " " '' cord-015021-pol2qm74 4824 27 effect effect NN cord-015021-pol2qm74 4824 28 . . . cord-015021-pol2qm74 4825 1 We -PRON- PRP cord-015021-pol2qm74 4825 2 examined examine VBD cord-015021-pol2qm74 4825 3 the the DT cord-015021-pol2qm74 4825 4 effect effect NN cord-015021-pol2qm74 4825 5 of of IN cord-015021-pol2qm74 4825 6 GTN GTN NNP cord-015021-pol2qm74 4825 7 on on IN cord-015021-pol2qm74 4825 8 lung lung NN cord-015021-pol2qm74 4825 9 injury injury NN cord-015021-pol2qm74 4825 10 , , , cord-015021-pol2qm74 4825 11 neutrophil neutrophil NN cord-015021-pol2qm74 4825 12 infiltration infiltration NN cord-015021-pol2qm74 4825 13 and and CC cord-015021-pol2qm74 4825 14 activation activation NN cord-015021-pol2qm74 4825 15 in in IN cord-015021-pol2qm74 4825 16 a a DT cord-015021-pol2qm74 4825 17 model model NN cord-015021-pol2qm74 4825 18 of of IN cord-015021-pol2qm74 4825 19 aortic aortic JJ cord-015021-pol2qm74 4825 20 occlusion occlusion NN cord-015021-pol2qm74 4825 21 ( ( -LRB- cord-015021-pol2qm74 4825 22 30 30 CD cord-015021-pol2qm74 4825 23 rain rain NN cord-015021-pol2qm74 4825 24 ) ) -RRB- cord-015021-pol2qm74 4825 25 and and CC cord-015021-pol2qm74 4825 26 repeffusion repeffusion NN cord-015021-pol2qm74 4825 27 ( ( -LRB- cord-015021-pol2qm74 4825 28 120 120 CD cord-015021-pol2qm74 4825 29 min min NN cord-015021-pol2qm74 4825 30 ) ) -RRB- cord-015021-pol2qm74 4825 31 . . . cord-015021-pol2qm74 4826 1 Sprague Sprague NNP cord-015021-pol2qm74 4826 2 Dawley Dawley NNP cord-015021-pol2qm74 4826 3 rats rat NNS cord-015021-pol2qm74 4826 4 were be VBD cord-015021-pol2qm74 4826 5 randomized randomize VBN cord-015021-pol2qm74 4826 6 into into IN cord-015021-pol2qm74 4826 7 : : : cord-015021-pol2qm74 4826 8 control control NN cord-015021-pol2qm74 4826 9 ( ( -LRB- cord-015021-pol2qm74 4826 10 N n NN cord-015021-pol2qm74 4826 11 = = SYM cord-015021-pol2qm74 4826 12 I i NN cord-015021-pol2qm74 4826 13 1 1 CD cord-015021-pol2qm74 4826 14 ) ) -RRB- cord-015021-pol2qm74 4826 15 ; ; : cord-015021-pol2qm74 4826 16 ischaemia ischaemia NN cord-015021-pol2qm74 4826 17 repeffusion repeffusion NN cord-015021-pol2qm74 4826 18 ( ( -LRB- cord-015021-pol2qm74 4826 19 IR IR NNP cord-015021-pol2qm74 4826 20 ) ) -RRB- cord-015021-pol2qm74 4826 21 ( ( -LRB- cord-015021-pol2qm74 4826 22 N=12 N=12 NNP cord-015021-pol2qm74 4826 23 ) ) -RRB- cord-015021-pol2qm74 4826 24 ; ; : cord-015021-pol2qm74 4826 25 and and CC cord-015021-pol2qm74 4826 26 IR IR NNP cord-015021-pol2qm74 4826 27 treated treat VBN cord-015021-pol2qm74 4826 28 with with IN cord-015021-pol2qm74 4826 29 GTN GTN NNP cord-015021-pol2qm74 4826 30 ( ( -LRB- cord-015021-pol2qm74 4826 31 2ug 2ug NNP cord-015021-pol2qm74 4826 32 / / SYM cord-015021-pol2qm74 4826 33 kg kg NN cord-015021-pol2qm74 4826 34 / / SYM cord-015021-pol2qm74 4826 35 min min NN cord-015021-pol2qm74 4826 36 ) ) -RRB- cord-015021-pol2qm74 4826 37 during during IN cord-015021-pol2qm74 4826 38 repeffusion repeffusion NN cord-015021-pol2qm74 4826 39 ( ( -LRB- cord-015021-pol2qm74 4826 40 N=10 N=10 NNP cord-015021-pol2qm74 4826 41 ) ) -RRB- cord-015021-pol2qm74 4826 42 . . . cord-015021-pol2qm74 4827 1 Myeloperoxidase myeloperoxidase NN cord-015021-pol2qm74 4827 2 activity activity NN cord-015021-pol2qm74 4827 3 ( ( -LRB- cord-015021-pol2qm74 4827 4 MPO MPO NNP cord-015021-pol2qm74 4827 5 ) ) -RRB- cord-015021-pol2qm74 4827 6 measured measure VBN cord-015021-pol2qm74 4827 7 pulmonary pulmonary JJ cord-015021-pol2qm74 4827 8 neutrophil neutrophil NN cord-015021-pol2qm74 4827 9 influx influx NN cord-015021-pol2qm74 4827 10 . . . cord-015021-pol2qm74 4828 1 Pulmonary pulmonary JJ cord-015021-pol2qm74 4828 2 endothelial endothelial JJ cord-015021-pol2qm74 4828 3 permeability permeability NN cord-015021-pol2qm74 4828 4 was be VBD cord-015021-pol2qm74 4828 5 measured measure VBN cord-015021-pol2qm74 4828 6 by by IN cord-015021-pol2qm74 4828 7 wet wet JJ cord-015021-pol2qm74 4828 8 to to IN cord-015021-pol2qm74 4828 9 dry dry JJ cord-015021-pol2qm74 4828 10 weight weight NN cord-015021-pol2qm74 4828 11 ratio ratio NN cord-015021-pol2qm74 4828 12 ( ( -LRB- cord-015021-pol2qm74 4828 13 W w NN cord-015021-pol2qm74 4828 14 / / SYM cord-015021-pol2qm74 4828 15 D D NNP cord-015021-pol2qm74 4828 16 ) ) -RRB- cord-015021-pol2qm74 4828 17 , , , cord-015021-pol2qm74 4828 18 broncboalveolar broncboalveolar NNP cord-015021-pol2qm74 4828 19 lavage lavage NNP cord-015021-pol2qm74 4828 20 protein protein NN cord-015021-pol2qm74 4828 21 ( ( -LRB- cord-015021-pol2qm74 4828 22 BAL BAL NNP cord-015021-pol2qm74 4828 23 ) ) -RRB- cord-015021-pol2qm74 4828 24 and and CC cord-015021-pol2qm74 4828 25 neutrophil neutrophil NN cord-015021-pol2qm74 4828 26 counts count NNS cord-015021-pol2qm74 4828 27 ( ( -LRB- cord-015021-pol2qm74 4828 28 BAL BAL NNP cord-015021-pol2qm74 4828 29 pmn pmn NN cord-015021-pol2qm74 4828 30 ) ) -RRB- cord-015021-pol2qm74 4828 31 . . . cord-015021-pol2qm74 4829 1 Neutrophil Neutrophil NNP cord-015021-pol2qm74 4829 2 superoxide superoxide NN cord-015021-pol2qm74 4829 3 release release NN cord-015021-pol2qm74 4829 4 ( ( -LRB- cord-015021-pol2qm74 4829 5 mean mean VB cord-015021-pol2qm74 4829 6 channel channel NN cord-015021-pol2qm74 4829 7 fluorescence fluorescence NN cord-015021-pol2qm74 4829 8 MCF MCF NNP cord-015021-pol2qm74 4829 9 ) ) -RRB- cord-015021-pol2qm74 4829 10 was be VBD cord-015021-pol2qm74 4829 11 measured measure VBN cord-015021-pol2qm74 4829 12 by by IN cord-015021-pol2qm74 4829 13 flow flow NN cord-015021-pol2qm74 4829 14 cytometry cytometry NN cord-015021-pol2qm74 4829 15 in in IN cord-015021-pol2qm74 4829 16 a a DT cord-015021-pol2qm74 4829 17 further further JJ cord-015021-pol2qm74 4829 18 IR IR NNP cord-015021-pol2qm74 4829 19 v v IN cord-015021-pol2qm74 4829 20 GTN GTN NNP cord-015021-pol2qm74 4829 21 experiment experiment NN cord-015021-pol2qm74 4829 22 ( ( -LRB- cord-015021-pol2qm74 4829 23 N=6 N=6 NNP cord-015021-pol2qm74 4829 24 per per IN cord-015021-pol2qm74 4829 25 group group NN cord-015021-pol2qm74 4829 26 ) ) -RRB- cord-015021-pol2qm74 4829 27 . . . cord-015021-pol2qm74 4830 1 Control control NN cord-015021-pol2qm74 4830 2 573_+t02 573_+t02 CD cord-015021-pol2qm74 4830 3 " " '' cord-015021-pol2qm74 4831 1 * * NFP cord-015021-pol2qm74 4831 2 992_+125 992_+125 CD cord-015021-pol2qm74 4831 3 579_+54 579_+54 XX cord-015021-pol2qm74 4832 1 * * NFP cord-015021-pol2qm74 4832 2 * * NFP cord-015021-pol2qm74 4832 3 BAL BAL NNP cord-015021-pol2qm74 4832 4 pmn pmn NN cord-015021-pol2qm74 4832 5 / / SYM cord-015021-pol2qm74 4832 6 mm mm NN cord-015021-pol2qm74 4833 1 3 3 CD cord-015021-pol2qm74 4833 2 36l+-126 36l+-126 CD cord-015021-pol2qm74 4833 3 3"219 3"219 NNS cord-015021-pol2qm74 4833 4 + + CD cord-015021-pol2qm74 4833 5 1087 1087 CD cord-015021-pol2qm74 4833 6 # # $ cord-015021-pol2qm74 4833 7 820_~221 820_~221 CD cord-015021-pol2qm74 4833 8 * * NFP cord-015021-pol2qm74 4833 9 p<0.05 p<0.05 NN cord-015021-pol2qm74 4833 10 , , , cord-015021-pol2qm74 4833 11 # # NN cord-015021-pol2qm74 4833 12 p<0.02 p<0.02 NN cord-015021-pol2qm74 4833 13 v v IN cord-015021-pol2qm74 4833 14 Control Control NNP cord-015021-pol2qm74 4833 15 / / SYM cord-015021-pol2qm74 4833 16 GTN;**p<0.01 GTN;**p<0.01 NNP cord-015021-pol2qm74 4833 17 v v NNP cord-015021-pol2qm74 4833 18 IR IR NNP cord-015021-pol2qm74 4833 19 . . . cord-015021-pol2qm74 4834 1 Students student NNS cord-015021-pol2qm74 4834 2 t t NN cord-015021-pol2qm74 4834 3 test test NN cord-015021-pol2qm74 4835 1 The the DT cord-015021-pol2qm74 4835 2 significant significant JJ cord-015021-pol2qm74 4835 3 increase increase NN cord-015021-pol2qm74 4835 4 in in IN cord-015021-pol2qm74 4835 5 MPO MPO NNP cord-015021-pol2qm74 4835 6 activity activity NN cord-015021-pol2qm74 4835 7 produced produce VBN cord-015021-pol2qm74 4835 8 by by IN cord-015021-pol2qm74 4835 9 IR IR NNP cord-015021-pol2qm74 4835 10 was be VBD cord-015021-pol2qm74 4835 11 attenuated attenuate VBN cord-015021-pol2qm74 4835 12 by by IN cord-015021-pol2qm74 4835 13 GTN GTN NNP cord-015021-pol2qm74 4835 14 . . . cord-015021-pol2qm74 4836 1 The the DT cord-015021-pol2qm74 4836 2 increase increase NN cord-015021-pol2qm74 4836 3 in in IN cord-015021-pol2qm74 4836 4 pulmonary pulmonary JJ cord-015021-pol2qm74 4836 5 microvascular microvascular JJ cord-015021-pol2qm74 4836 6 leakage leakage NN cord-015021-pol2qm74 4836 7 after after IN cord-015021-pol2qm74 4836 8 reperfusion reperfusion NN cord-015021-pol2qm74 4836 9 was be VBD cord-015021-pol2qm74 4836 10 also also RB cord-015021-pol2qm74 4836 11 prevented prevent VBN cord-015021-pol2qm74 4836 12 by by IN cord-015021-pol2qm74 4836 13 GTN GTN NNP cord-015021-pol2qm74 4836 14 . . . cord-015021-pol2qm74 4837 1 Neutrophil Neutrophil NNP cord-015021-pol2qm74 4837 2 superoxide superoxide NN cord-015021-pol2qm74 4837 3 release release NN cord-015021-pol2qm74 4837 4 increased increase VBD cord-015021-pol2qm74 4837 5 significantly significantly RB cord-015021-pol2qm74 4837 6 from from IN cord-015021-pol2qm74 4837 7 9.4 9.4 CD cord-015021-pol2qm74 4837 8 + + CD cord-015021-pol2qm74 4837 9 0.76 0.76 CD cord-015021-pol2qm74 4837 10 to to IN cord-015021-pol2qm74 4837 11 13.9_+1.92 13.9_+1.92 CD cord-015021-pol2qm74 4837 12 MCF MCF NNP cord-015021-pol2qm74 4837 13 after after IN cord-015021-pol2qm74 4837 14 40 40 CD cord-015021-pol2qm74 4837 15 minutes minute NNS cord-015021-pol2qm74 4837 16 repeffusion repeffusion NN cord-015021-pol2qm74 4837 17 ( ( -LRB- cord-015021-pol2qm74 4837 18 p<.01 p<.01 NNP cord-015021-pol2qm74 4837 19 ) ) -RRB- cord-015021-pol2qm74 4837 20 . . . cord-015021-pol2qm74 4838 1 This this DT cord-015021-pol2qm74 4838 2 increase increase NN cord-015021-pol2qm74 4838 3 in in IN cord-015021-pol2qm74 4838 4 superoxide superoxide NN cord-015021-pol2qm74 4838 5 was be VBD cord-015021-pol2qm74 4838 6 prevented prevent VBN cord-015021-pol2qm74 4838 7 in in IN cord-015021-pol2qm74 4838 8 the the DT cord-015021-pol2qm74 4838 9 GTN GTN NNP cord-015021-pol2qm74 4838 10 treated treat VBN cord-015021-pol2qm74 4838 11 group group NN cord-015021-pol2qm74 4838 12 . . . cord-015021-pol2qm74 4839 1 These these DT cord-015021-pol2qm74 4839 2 results result NNS cord-015021-pol2qm74 4839 3 indicate indicate VBP cord-015021-pol2qm74 4839 4 that that IN cord-015021-pol2qm74 4839 5 GTN GTN NNP cord-015021-pol2qm74 4839 6 inhibits inhibit VBZ cord-015021-pol2qm74 4839 7 neutropbil neutropbil NN cord-015021-pol2qm74 4839 8 superoxide superoxide NN cord-015021-pol2qm74 4839 9 release release NN cord-015021-pol2qm74 4839 10 during during IN cord-015021-pol2qm74 4839 11 limb limb NN cord-015021-pol2qm74 4839 12 reperfusion reperfusion NN cord-015021-pol2qm74 4839 13 , , , cord-015021-pol2qm74 4839 14 thus thus RB cord-015021-pol2qm74 4839 15 preventing prevent VBG cord-015021-pol2qm74 4839 16 pulmonary pulmonary JJ cord-015021-pol2qm74 4839 17 vascular vascular JJ cord-015021-pol2qm74 4839 18 leakage leakage NN cord-015021-pol2qm74 4839 19 and and CC cord-015021-pol2qm74 4839 20 neutrophil neutrophil NN cord-015021-pol2qm74 4839 21 infiltration infiltration NN cord-015021-pol2qm74 4839 22 . . . cord-015021-pol2qm74 4840 1 These these DT cord-015021-pol2qm74 4840 2 data datum NNS cord-015021-pol2qm74 4840 3 suggest suggest VBP cord-015021-pol2qm74 4840 4 that that IN cord-015021-pol2qm74 4840 5 the the DT cord-015021-pol2qm74 4840 6 beneficial beneficial JJ cord-015021-pol2qm74 4840 7 effects effect NNS cord-015021-pol2qm74 4840 8 of of IN cord-015021-pol2qm74 4840 9 GTN GTN NNP cord-015021-pol2qm74 4840 10 in in IN cord-015021-pol2qm74 4840 11 aortic aortic JJ cord-015021-pol2qm74 4840 12 surgery surgery NN cord-015021-pol2qm74 4840 13 may may MD cord-015021-pol2qm74 4840 14 be be VB cord-015021-pol2qm74 4840 15 due due JJ cord-015021-pol2qm74 4840 16 in in IN cord-015021-pol2qm74 4840 17 part part NN cord-015021-pol2qm74 4840 18 to to IN cord-015021-pol2qm74 4840 19 a a DT cord-015021-pol2qm74 4840 20 protective protective JJ cord-015021-pol2qm74 4840 21 effect effect NN cord-015021-pol2qm74 4840 22 onpulmonary onpulmonary JJ cord-015021-pol2qm74 4840 23 microvasculature microvasculature NN cord-015021-pol2qm74 4840 24 . . . cord-015021-pol2qm74 4841 1 Department Department NNP cord-015021-pol2qm74 4841 2 of of IN cord-015021-pol2qm74 4841 3 Surgery Surgery NNP cord-015021-pol2qm74 4841 4 , , , cord-015021-pol2qm74 4841 5 Beaumont Beaumont NNP cord-015021-pol2qm74 4841 6 Hospital Hospital NNP cord-015021-pol2qm74 4841 7 , , , cord-015021-pol2qm74 4841 8 Dublin Dublin NNP cord-015021-pol2qm74 4841 9 9 9 CD cord-015021-pol2qm74 4841 10 , , , cord-015021-pol2qm74 4841 11 Ireland Ireland NNP cord-015021-pol2qm74 4841 12 . . . cord-015021-pol2qm74 4842 1 LIPTON LIPTON NNP cord-015021-pol2qm74 4842 2 Adult Adult NNP cord-015021-pol2qm74 4842 3 respiratory respiratory JJ cord-015021-pol2qm74 4842 4 distress distress NN cord-015021-pol2qm74 4842 5 syndrome syndrome NN cord-015021-pol2qm74 4842 6 ( ( -LRB- cord-015021-pol2qm74 4842 7 ARDS ARDS NNP cord-015021-pol2qm74 4842 8 ) ) -RRB- cord-015021-pol2qm74 4842 9 is be VBZ cord-015021-pol2qm74 4842 10 marked mark VBN cord-015021-pol2qm74 4842 11 by by IN cord-015021-pol2qm74 4842 12 increased increase VBN cord-015021-pol2qm74 4842 13 vascular vascular JJ cord-015021-pol2qm74 4842 14 permeability permeability NN cord-015021-pol2qm74 4842 15 of of IN cord-015021-pol2qm74 4842 16 the the DT cord-015021-pol2qm74 4842 17 lung lung NN cord-015021-pol2qm74 4842 18 to to IN cord-015021-pol2qm74 4842 19 white white NNP cord-015021-pol2qm74 4842 20 blood blood NN cord-015021-pol2qm74 4842 21 ceils ceil NNS cord-015021-pol2qm74 4842 22 ( ( -LRB- cord-015021-pol2qm74 4842 23 WBC WBC NNP cord-015021-pol2qm74 4842 24 ) ) -RRB- cord-015021-pol2qm74 4842 25 . . . cord-015021-pol2qm74 4843 1 Indeed indeed RB cord-015021-pol2qm74 4843 2 , , , cord-015021-pol2qm74 4843 3 influx influx NN cord-015021-pol2qm74 4843 4 of of IN cord-015021-pol2qm74 4843 5 WBC WBC NNP cord-015021-pol2qm74 4843 6 into into IN cord-015021-pol2qm74 4843 7 the the DT cord-015021-pol2qm74 4843 8 lung lung NN cord-015021-pol2qm74 4843 9 is be VBZ cord-015021-pol2qm74 4843 10 believed believe VBN cord-015021-pol2qm74 4843 11 to to TO cord-015021-pol2qm74 4843 12 be be VB cord-015021-pol2qm74 4843 13 the the DT cord-015021-pol2qm74 4843 14 central central JJ cord-015021-pol2qm74 4843 15 mechanism mechanism NN cord-015021-pol2qm74 4843 16 in in IN cord-015021-pol2qm74 4843 17 acute acute JJ cord-015021-pol2qm74 4843 18 lung lung NN cord-015021-pol2qm74 4843 19 injury injury NN cord-015021-pol2qm74 4843 20 of of IN cord-015021-pol2qm74 4843 21 ARDS ARDS NNP cord-015021-pol2qm74 4843 22 . . . cord-015021-pol2qm74 4844 1 Evidence evidence NN cord-015021-pol2qm74 4844 2 is be VBZ cord-015021-pol2qm74 4844 3 developing develop VBG cord-015021-pol2qm74 4844 4 that that IN cord-015021-pol2qm74 4844 5 the the DT cord-015021-pol2qm74 4844 6 neuropeptide neuropeptide NN cord-015021-pol2qm74 4844 7 c~-melanocyte c~-melanocyte FW cord-015021-pol2qm74 4844 8 stimulating stimulate VBG cord-015021-pol2qm74 4844 9 hormone hormone NN cord-015021-pol2qm74 4844 10 ( ( -LRB- cord-015021-pol2qm74 4844 11 c~-MSH c~-MSH NNP cord-015021-pol2qm74 4844 12 ) ) -RRB- cord-015021-pol2qm74 4844 13 , , , cord-015021-pol2qm74 4844 14 a a DT cord-015021-pol2qm74 4844 15 proopiomelanocortin proopiomelanocortin NN cord-015021-pol2qm74 4844 16 derivative derivative NN cord-015021-pol2qm74 4844 17 , , , cord-015021-pol2qm74 4844 18 inhibits inhibit VBZ cord-015021-pol2qm74 4844 19 inflammatory inflammatory JJ cord-015021-pol2qm74 4844 20 reactions reaction NNS cord-015021-pol2qm74 4844 21 in in IN cord-015021-pol2qm74 4844 22 animaI animaI NNP cord-015021-pol2qm74 4844 23 models model NNS cord-015021-pol2qm74 4844 24 of of IN cord-015021-pol2qm74 4844 25 inflammatory inflammatory JJ cord-015021-pol2qm74 4844 26 responses response NNS cord-015021-pol2qm74 4844 27 in in IN cord-015021-pol2qm74 4844 28 humans human NNS cord-015021-pol2qm74 4844 29 . . . cord-015021-pol2qm74 4845 1 To to TO cord-015021-pol2qm74 4845 2 test test VB cord-015021-pol2qm74 4845 3 the the DT cord-015021-pol2qm74 4845 4 influence influence NN cord-015021-pol2qm74 4845 5 of of IN cord-015021-pol2qm74 4845 6 a a DT cord-015021-pol2qm74 4845 7 - - : cord-015021-pol2qm74 4845 8 MSH MSH NNP cord-015021-pol2qm74 4845 9 on on IN cord-015021-pol2qm74 4845 10 experimental experimental JJ cord-015021-pol2qm74 4845 11 ARDS ARDS NNP cord-015021-pol2qm74 4845 12 , , , cord-015021-pol2qm74 4845 13 the the DT cord-015021-pol2qm74 4845 14 peptide peptide NN cord-015021-pol2qm74 4845 15 was be VBD cord-015021-pol2qm74 4845 16 administered administer VBN cord-015021-pol2qm74 4845 17 to to IN cord-015021-pol2qm74 4845 18 rats rat NNS cord-015021-pol2qm74 4845 19 after after IN cord-015021-pol2qm74 4845 20 intratraeheal intratraeheal JJ cord-015021-pol2qm74 4845 21 infusion infusion NN cord-015021-pol2qm74 4845 22 of of IN cord-015021-pol2qm74 4845 23 endotoxin endotoxin NN cord-015021-pol2qm74 4845 24 ( ( -LRB- cord-015021-pol2qm74 4845 25 S. S. NNP cord-015021-pol2qm74 4845 26 typhosa typhosa NNP cord-015021-pol2qm74 4845 27 , , , cord-015021-pol2qm74 4845 28 500 500 CD cord-015021-pol2qm74 4845 29 # # $ cord-015021-pol2qm74 4845 30 g g NN cord-015021-pol2qm74 4845 31 in in IN cord-015021-pol2qm74 4845 32 0.25 0.25 CD cord-015021-pol2qm74 4845 33 ml ml NN cord-015021-pol2qm74 4845 34 saline saline NN cord-015021-pol2qm74 4845 35 ) ) -RRB- cord-015021-pol2qm74 4845 36 . . . cord-015021-pol2qm74 4846 1 Three three CD cord-015021-pol2qm74 4846 2 groups group NNS cord-015021-pol2qm74 4846 3 ( ( -LRB- cord-015021-pol2qm74 4846 4 n=10 n=10 `` cord-015021-pol2qm74 4846 5 each each DT cord-015021-pol2qm74 4846 6 ) ) -RRB- cord-015021-pol2qm74 4846 7 received receive VBD cord-015021-pol2qm74 4846 8 : : : cord-015021-pol2qm74 4846 9 intratracheai intratracheai NNP cord-015021-pol2qm74 4846 10 infusion infusion NN cord-015021-pol2qm74 4846 11 of of IN cord-015021-pol2qm74 4846 12 endotoxin endotoxin NN cord-015021-pol2qm74 4846 13 plus plus CC cord-015021-pol2qm74 4846 14 ip ip NN cord-015021-pol2qm74 4846 15 injections injection NNS cord-015021-pol2qm74 4846 16 of of IN cord-015021-pol2qm74 4846 17 o~-MSH o~-MSH NNP cord-015021-pol2qm74 4847 1 ( ( -LRB- cord-015021-pol2qm74 4847 2 100 100 CD cord-015021-pol2qm74 4848 1 ~tg ~tg NNP cord-015021-pol2qm74 4849 1 in in IN cord-015021-pol2qm74 4849 2 0.2 0.2 CD cord-015021-pol2qm74 4849 3 ml ml NN cord-015021-pol2qm74 4849 4 saline saline NN cord-015021-pol2qm74 4849 5 ) ) -RRB- cord-015021-pol2qm74 4849 6 at at IN cord-015021-pol2qm74 4849 7 0 0 CD cord-015021-pol2qm74 4849 8 , , , cord-015021-pol2qm74 4849 9 2 2 CD cord-015021-pol2qm74 4849 10 , , , cord-015021-pol2qm74 4849 11 and and CC cord-015021-pol2qm74 4849 12 4 4 CD cord-015021-pol2qm74 4849 13 hr hr NN cord-015021-pol2qm74 4849 14 post post JJ cord-015021-pol2qm74 4849 15 - - JJ cord-015021-pol2qm74 4849 16 endotoxin endotoxin JJ cord-015021-pol2qm74 4849 17 treatment treatment NN cord-015021-pol2qm74 4849 18 ; ; : cord-015021-pol2qm74 4849 19 intratracheal intratracheal NN cord-015021-pol2qm74 4849 20 endotoxin endotoxin NN cord-015021-pol2qm74 4849 21 infusion infusion NN cord-015021-pol2qm74 4849 22 plus plus CC cord-015021-pol2qm74 4849 23 saline saline NN cord-015021-pol2qm74 4849 24 injections injection NNS cord-015021-pol2qm74 4849 25 ; ; : cord-015021-pol2qm74 4849 26 control control NNP cord-015021-pol2qm74 4849 27 intratracheal intratracheal NNP cord-015021-pol2qm74 4849 28 saline saline NN cord-015021-pol2qm74 4849 29 infusion infusion NN cord-015021-pol2qm74 4849 30 plus plus IN cord-015021-pol2qm74 4849 31 saline saline NN cord-015021-pol2qm74 4849 32 injections injection NNS cord-015021-pol2qm74 4849 33 . . . cord-015021-pol2qm74 4850 1 The the DT cord-015021-pol2qm74 4850 2 BAL BAL NNP cord-015021-pol2qm74 4850 3 data datum NNS cord-015021-pol2qm74 4850 4 showed show VBD cord-015021-pol2qm74 4850 5 overall overall JJ cord-015021-pol2qm74 4850 6 differences difference NNS cord-015021-pol2qm74 4850 7 among among IN cord-015021-pol2qm74 4850 8 groups group NNS cord-015021-pol2qm74 4850 9 ( ( -LRB- cord-015021-pol2qm74 4850 10 F2,29=6.2 F2,29=6.2 NNP cord-015021-pol2qm74 4850 11 , , , cord-015021-pol2qm74 4850 12 p<.003 p<.003 NNP cord-015021-pol2qm74 4850 13 ) ) -RRB- cord-015021-pol2qm74 4850 14 , , , cord-015021-pol2qm74 4850 15 o~-MSH o~-MSH NNP cord-015021-pol2qm74 4850 16 treatment treatment NN cord-015021-pol2qm74 4850 17 inhibited inhibit VBN cord-015021-pol2qm74 4850 18 endotoxin endotoxin NN cord-015021-pol2qm74 4850 19 - - HYPH cord-015021-pol2qm74 4850 20 induced induce VBN cord-015021-pol2qm74 4850 21 WBC WBC NNP cord-015021-pol2qm74 4850 22 migration migration NN cord-015021-pol2qm74 4850 23 into into IN cord-015021-pol2qm74 4850 24 the the DT cord-015021-pol2qm74 4850 25 pulmonary pulmonary JJ cord-015021-pol2qm74 4850 26 tree tree NN cord-015021-pol2qm74 4850 27 ( ( -LRB- cord-015021-pol2qm74 4850 28 p<.05 p<.05 NNP cord-015021-pol2qm74 4850 29 ) ) -RRB- cord-015021-pol2qm74 4850 30 . . . cord-015021-pol2qm74 4851 1 Circulating circulate VBG cord-015021-pol2qm74 4851 2 WBC WBC NNP cord-015021-pol2qm74 4851 3 counts count NNS cord-015021-pol2qm74 4851 4 were be VBD cord-015021-pol2qm74 4851 5 markedly markedly RB cord-015021-pol2qm74 4851 6 lower low JJR cord-015021-pol2qm74 4851 7 in in IN cord-015021-pol2qm74 4851 8 both both DT cord-015021-pol2qm74 4851 9 groups group NNS cord-015021-pol2qm74 4851 10 given give VBN cord-015021-pol2qm74 4851 11 endoroxin endoroxin NNP cord-015021-pol2qm74 4851 12 than than IN cord-015021-pol2qm74 4851 13 in in IN cord-015021-pol2qm74 4851 14 the the DT cord-015021-pol2qm74 4851 15 control control NN cord-015021-pol2qm74 4851 16 group group NN cord-015021-pol2qm74 4851 17 ( ( -LRB- cord-015021-pol2qm74 4851 18 p<.01 p<.01 NNP cord-015021-pol2qm74 4851 19 ) ) -RRB- cord-015021-pol2qm74 4851 20 , , , cord-015021-pol2qm74 4851 21 but but CC cord-015021-pol2qm74 4851 22 there there EX cord-015021-pol2qm74 4851 23 was be VBD cord-015021-pol2qm74 4851 24 no no DT cord-015021-pol2qm74 4851 25 difference difference NN cord-015021-pol2qm74 4851 26 in in IN cord-015021-pol2qm74 4851 27 WBC WBC NNP cord-015021-pol2qm74 4851 28 count count NN cord-015021-pol2qm74 4851 29 between between IN cord-015021-pol2qm74 4851 30 these these DT cord-015021-pol2qm74 4851 31 two two CD cord-015021-pol2qm74 4851 32 endotoxin endotoxin NN cord-015021-pol2qm74 4851 33 - - HYPH cord-015021-pol2qm74 4851 34 treated treat VBN cord-015021-pol2qm74 4851 35 groups group NNS cord-015021-pol2qm74 4851 36 . . . cord-015021-pol2qm74 4852 1 The the DT cord-015021-pol2qm74 4852 2 results result NNS cord-015021-pol2qm74 4852 3 indicate indicate VBP cord-015021-pol2qm74 4852 4 that that IN cord-015021-pol2qm74 4852 5 c~-MSH c~-msh NN cord-015021-pol2qm74 4852 6 can can MD cord-015021-pol2qm74 4852 7 reduce reduce VB cord-015021-pol2qm74 4852 8 WBC WBC NNP cord-015021-pol2qm74 4852 9 migration migration NN cord-015021-pol2qm74 4852 10 in in IN cord-015021-pol2qm74 4852 11 experimental experimental JJ cord-015021-pol2qm74 4852 12 lung lung NN cord-015021-pol2qm74 4852 13 injury injury NN cord-015021-pol2qm74 4852 14 . . . cord-015021-pol2qm74 4853 1 In in IN cord-015021-pol2qm74 4853 2 further further JJ cord-015021-pol2qm74 4853 3 experiments experiment NNS cord-015021-pol2qm74 4853 4 we -PRON- PRP cord-015021-pol2qm74 4853 5 tested test VBD cord-015021-pol2qm74 4853 6 the the DT cord-015021-pol2qm74 4853 7 hypothesis hypothesis NN cord-015021-pol2qm74 4853 8 that that IN cord-015021-pol2qm74 4853 9 c~-MSH c~-MSH NNP cord-015021-pol2qm74 4853 10 , , , cord-015021-pol2qm74 4853 11 administered administer VBN cord-015021-pol2qm74 4853 12 alone alone RB cord-015021-pol2qm74 4853 13 or or CC cord-015021-pol2qm74 4853 14 in in IN cord-015021-pol2qm74 4853 15 combination combination NN cord-015021-pol2qm74 4853 16 with with IN cord-015021-pol2qm74 4853 17 an an DT cord-015021-pol2qm74 4853 18 inhibitor inhibitor NN cord-015021-pol2qm74 4853 19 of of IN cord-015021-pol2qm74 4853 20 gram gram JJ cord-015021-pol2qm74 4853 21 - - HYPH cord-015021-pol2qm74 4853 22 negative negative JJ cord-015021-pol2qm74 4853 23 bacterial bacterial JJ cord-015021-pol2qm74 4853 24 growth growth NN cord-015021-pol2qm74 4853 25 , , , cord-015021-pol2qm74 4853 26 increases increase VBZ cord-015021-pol2qm74 4853 27 survival survival NN cord-015021-pol2qm74 4853 28 in in IN cord-015021-pol2qm74 4853 29 a a DT cord-015021-pol2qm74 4853 30 model model NN cord-015021-pol2qm74 4853 31 of of IN cord-015021-pol2qm74 4853 32 peritonitis peritonitis NN cord-015021-pol2qm74 4853 33 / / SYM cord-015021-pol2qm74 4853 34 endotoxemia endotoxemia NN cord-015021-pol2qm74 4853 35 / / SYM cord-015021-pol2qm74 4853 36 septie septie NN cord-015021-pol2qm74 4853 37 shock shock NN cord-015021-pol2qm74 4853 38 . . . cord-015021-pol2qm74 4854 1 Cecal Cecal NNP cord-015021-pol2qm74 4854 2 ligation ligation NN cord-015021-pol2qm74 4854 3 and and CC cord-015021-pol2qm74 4854 4 puncture puncture NN cord-015021-pol2qm74 4854 5 were be VBD cord-015021-pol2qm74 4854 6 performed perform VBN cord-015021-pol2qm74 4854 7 under under IN cord-015021-pol2qm74 4854 8 sodium sodium NN cord-015021-pol2qm74 4854 9 pemobarbital pemobarbital NNP cord-015021-pol2qm74 4854 10 anesthesia anesthesia NNP cord-015021-pol2qm74 4854 11 ( ( -LRB- cord-015021-pol2qm74 4854 12 75 75 CD cord-015021-pol2qm74 4854 13 mg mg NNP cord-015021-pol2qm74 4854 14 / / SYM cord-015021-pol2qm74 4854 15 kg kg NNP cord-015021-pol2qm74 4854 16 , , , cord-015021-pol2qm74 4854 17 i.p i.p NNP cord-015021-pol2qm74 4854 18 . . NNP cord-015021-pol2qm74 4854 19 ) ) -RRB- cord-015021-pol2qm74 4854 20 in in IN cord-015021-pol2qm74 4854 21 female female JJ cord-015021-pol2qm74 4854 22 BALB BALB NNP cord-015021-pol2qm74 4854 23 / / SYM cord-015021-pol2qm74 4854 24 c c NN cord-015021-pol2qm74 4854 25 mice mouse NNS cord-015021-pol2qm74 4854 26 ( ( -LRB- cord-015021-pol2qm74 4854 27 16 16 CD cord-015021-pol2qm74 4854 28 - - SYM cord-015021-pol2qm74 4854 29 20 20 CD cord-015021-pol2qm74 4854 30 g g NN cord-015021-pol2qm74 4854 31 ) ) -RRB- cord-015021-pol2qm74 4854 32 that that WDT cord-015021-pol2qm74 4854 33 were be VBD cord-015021-pol2qm74 4854 34 then then RB cord-015021-pol2qm74 4854 35 randomly randomly RB cord-015021-pol2qm74 4854 36 assigned assign VBN cord-015021-pol2qm74 4854 37 ( ( -LRB- cord-015021-pol2qm74 4854 38 15 15 CD cord-015021-pol2qm74 4854 39 - - SYM cord-015021-pol2qm74 4854 40 17 17 CD cord-015021-pol2qm74 4854 41 mice mouse NNS cord-015021-pol2qm74 4854 42 per per IN cord-015021-pol2qm74 4854 43 group group NN cord-015021-pol2qm74 4854 44 ) ) -RRB- cord-015021-pol2qm74 4854 45 to to TO cord-015021-pol2qm74 4854 46 receive receive VB cord-015021-pol2qm74 4854 47 at at IN cord-015021-pol2qm74 4854 48 time time NN cord-015021-pol2qm74 4854 49 0 0 CD cord-015021-pol2qm74 4854 50 and and CC cord-015021-pol2qm74 4854 51 3 3 CD cord-015021-pol2qm74 4854 52 hr hr NN cord-015021-pol2qm74 4854 53 later later RB cord-015021-pol2qm74 4854 54 : : : cord-015021-pol2qm74 4854 55 control control NNP cord-015021-pol2qm74 4854 56 saline saline NNP cord-015021-pol2qm74 4854 57 thjectioas thjectioas NNP cord-015021-pol2qm74 4854 58 ( ( -LRB- cord-015021-pol2qm74 4854 59 i.p i.p NNP cord-015021-pol2qm74 4854 60 . . NNP cord-015021-pol2qm74 4854 61 ) ) -RRB- cord-015021-pol2qm74 4854 62 , , , cord-015021-pol2qm74 4854 63 injections injection NNS cord-015021-pol2qm74 4854 64 of of IN cord-015021-pol2qm74 4854 65 ~-MSH ~-msh CD cord-015021-pol2qm74 4855 1 ( ( -LRB- cord-015021-pol2qm74 4855 2 100 100 CD cord-015021-pol2qm74 4855 3 ~tg ~tg NNS cord-015021-pol2qm74 4855 4 ) ) -RRB- cord-015021-pol2qm74 4855 5 , , , cord-015021-pol2qm74 4855 6 gentamicin gentamicin NN cord-015021-pol2qm74 4855 7 sulfate sulfate NN cord-015021-pol2qm74 4855 8 ( ( -LRB- cord-015021-pol2qm74 4855 9 I0 I0 NNP cord-015021-pol2qm74 4855 10 mg mg NNP cord-015021-pol2qm74 4855 11 / / SYM cord-015021-pol2qm74 4855 12 kg kg NNP cord-015021-pol2qm74 4855 13 ) ) -RRB- cord-015021-pol2qm74 4855 14 , , , cord-015021-pol2qm74 4855 15 or or CC cord-015021-pol2qm74 4855 16 both both DT cord-015021-pol2qm74 4855 17 ~-MSH ~-msh CD cord-015021-pol2qm74 4855 18 and and CC cord-015021-pol2qm74 4855 19 gentamicin gentamicin NN cord-015021-pol2qm74 4855 20 . . . cord-015021-pol2qm74 4856 1 One one CD cord-015021-pol2qm74 4856 2 ml ml NN cord-015021-pol2qm74 4856 3 of of IN cord-015021-pol2qm74 4856 4 normal normal JJ cord-015021-pol2qm74 4856 5 saline saline NN cord-015021-pol2qm74 4856 6 was be VBD cord-015021-pol2qm74 4856 7 given give VBN cord-015021-pol2qm74 4856 8 s.c s.c NNP cord-015021-pol2qm74 4856 9 . . . cord-015021-pol2qm74 4857 1 to to IN cord-015021-pol2qm74 4857 2 each each DT cord-015021-pol2qm74 4857 3 animal animal NN cord-015021-pol2qm74 4857 4 for for IN cord-015021-pol2qm74 4857 5 fluid fluid JJ cord-015021-pol2qm74 4857 6 replacement replacement NN cord-015021-pol2qm74 4857 7 . . . cord-015021-pol2qm74 4858 1 Both both DT cord-015021-pol2qm74 4858 2 Ix Ix NNP cord-015021-pol2qm74 4858 3 - - HYPH cord-015021-pol2qm74 4858 4 MSH MSH NNP cord-015021-pol2qm74 4858 5 and and CC cord-015021-pol2qm74 4858 6 gentamicin gentamicin NN cord-015021-pol2qm74 4858 7 treatments treatment NNS cord-015021-pol2qm74 4858 8 administered administer VBN cord-015021-pol2qm74 4858 9 singly singly RB cord-015021-pol2qm74 4858 10 improved improve VBN cord-015021-pol2qm74 4858 11 survival survival NN cord-015021-pol2qm74 4858 12 ; ; : cord-015021-pol2qm74 4858 13 when when WRB cord-015021-pol2qm74 4858 14 given give VBN cord-015021-pol2qm74 4858 15 in in IN cord-015021-pol2qm74 4858 16 combination combination NN cord-015021-pol2qm74 4858 17 survival survival NN cord-015021-pol2qm74 4858 18 was be VBD cord-015021-pol2qm74 4858 19 even even RB cord-015021-pol2qm74 4858 20 greater great JJR cord-015021-pol2qm74 4858 21 These these DT cord-015021-pol2qm74 4858 22 findings finding NNS cord-015021-pol2qm74 4858 23 suggest suggest VBP cord-015021-pol2qm74 4858 24 that that IN cord-015021-pol2qm74 4858 25 the the DT cord-015021-pol2qm74 4858 26 anticytokine anticytokine NNP cord-015021-pol2qm74 4858 27 ot ot NN cord-015021-pol2qm74 4858 28 -MSH -msh NN cord-015021-pol2qm74 4858 29 molecule molecule NN cord-015021-pol2qm74 4858 30 might may MD cord-015021-pol2qm74 4858 31 be be VB cord-015021-pol2qm74 4858 32 useful useful JJ cord-015021-pol2qm74 4858 33 for for IN cord-015021-pol2qm74 4858 34 treatment treatment NN cord-015021-pol2qm74 4858 35 of of IN cord-015021-pol2qm74 4858 36 systemic systemic JJ cord-015021-pol2qm74 4858 37 inflammation inflammation NN cord-015021-pol2qm74 4858 38 , , , cord-015021-pol2qm74 4858 39 perhaps perhaps RB cord-015021-pol2qm74 4858 40 particularly particularly RB cord-015021-pol2qm74 4858 41 when when WRB cord-015021-pol2qm74 4858 42 used use VBN cord-015021-pol2qm74 4858 43 in in IN cord-015021-pol2qm74 4858 44 combination combination NN cord-015021-pol2qm74 4858 45 with with IN cord-015021-pol2qm74 4858 46 agents agent NNS cord-015021-pol2qm74 4858 47 that that WDT cord-015021-pol2qm74 4858 48 inhibit inhibit VBP cord-015021-pol2qm74 4858 49 bacterial bacterial JJ cord-015021-pol2qm74 4858 50 growth growth NN cord-015021-pol2qm74 4858 51 . . . cord-015021-pol2qm74 4859 1 Previous previous JJ cord-015021-pol2qm74 4859 2 studies study NNS cord-015021-pol2qm74 4859 3 showed show VBD cord-015021-pol2qm74 4859 4 a a DT cord-015021-pol2qm74 4859 5 close close JJ cord-015021-pol2qm74 4859 6 relationship relationship NN cord-015021-pol2qm74 4859 7 between between IN cord-015021-pol2qm74 4859 8 xanthine xanthine NN cord-015021-pol2qm74 4859 9 oxidase oxidase NN cord-015021-pol2qm74 4859 10 activation activation NN cord-015021-pol2qm74 4859 11 , , , cord-015021-pol2qm74 4859 12 membrane membrane NN cord-015021-pol2qm74 4859 13 damage damage NN cord-015021-pol2qm74 4859 14 and and CC cord-015021-pol2qm74 4859 15 postischemic postischemic JJ cord-015021-pol2qm74 4859 16 cardio cardio NN cord-015021-pol2qm74 4859 17 - - HYPH cord-015021-pol2qm74 4859 18 respiratory respiratory JJ cord-015021-pol2qm74 4859 19 failure failure NN cord-015021-pol2qm74 4859 20 following follow VBG cord-015021-pol2qm74 4859 21 aortic aortic JJ cord-015021-pol2qm74 4859 22 clamping clamping NN cord-015021-pol2qm74 4859 23 and and CC cord-015021-pol2qm74 4859 24 reperfusion reperfusion NN cord-015021-pol2qm74 4859 25 . . . cord-015021-pol2qm74 4860 1 Aim aim VB cord-015021-pol2qm74 4860 2 of of IN cord-015021-pol2qm74 4860 3 the the DT cord-015021-pol2qm74 4860 4 present present JJ cord-015021-pol2qm74 4860 5 study study NN cord-015021-pol2qm74 4860 6 was be VBD cord-015021-pol2qm74 4860 7 to to TO cord-015021-pol2qm74 4860 8 evaluate evaluate VB cord-015021-pol2qm74 4860 9 alterations alteration NNS cord-015021-pol2qm74 4860 10 of of IN cord-015021-pol2qm74 4860 11 polymorphonuclear polymorphonuclear JJ cord-015021-pol2qm74 4860 12 leukocyte leukocyte NN cord-015021-pol2qm74 4860 13 ( ( -LRB- cord-015021-pol2qm74 4860 14 PMNL)-metabolism PMNL)-metabolism NNP cord-015021-pol2qm74 4860 15 and and CC cord-015021-pol2qm74 4860 16 signal signal NN cord-015021-pol2qm74 4860 17 lransduction lransduction NN cord-015021-pol2qm74 4860 18 systems system NNS cord-015021-pol2qm74 4860 19 during during IN cord-015021-pol2qm74 4860 20 ischemia ischemia NN cord-015021-pol2qm74 4860 21 / / SYM cord-015021-pol2qm74 4860 22 reperfusion reperfusion NN cord-015021-pol2qm74 4860 23 induced induce VBN cord-015021-pol2qm74 4860 24 by by IN cord-015021-pol2qm74 4860 25 aortic aortic JJ cord-015021-pol2qm74 4860 26 clamping clamping NN cord-015021-pol2qm74 4860 27 in in IN cord-015021-pol2qm74 4860 28 man man NN cord-015021-pol2qm74 4860 29 . . . cord-015021-pol2qm74 4861 1 Methods method NNS cord-015021-pol2qm74 4861 2 , , , cord-015021-pol2qm74 4861 3 In in IN cord-015021-pol2qm74 4861 4 14 14 CD cord-015021-pol2qm74 4861 5 Patients patient NNS cord-015021-pol2qm74 4861 6 ( ( -LRB- cord-015021-pol2qm74 4861 7 3 3 CD cord-015021-pol2qm74 4861 8 female female JJ cord-015021-pol2qm74 4861 9 , , , cord-015021-pol2qm74 4861 10 59 59 CD cord-015021-pol2qm74 4861 11 + + SYM cord-015021-pol2qm74 4861 12 4 4 CD cord-015021-pol2qm74 4861 13 years year NNS cord-015021-pol2qm74 4861 14 ) ) -RRB- cord-015021-pol2qm74 4861 15 with with IN cord-015021-pol2qm74 4861 16 elective elective JJ cord-015021-pol2qm74 4861 17 reconstruction reconstruction NN cord-015021-pol2qm74 4861 18 of of IN cord-015021-pol2qm74 4861 19 infrarenal infrarenal JJ cord-015021-pol2qm74 4861 20 aortic aortic JJ cord-015021-pol2qm74 4861 21 anearysms anearysm NNS cord-015021-pol2qm74 4861 22 , , , cord-015021-pol2qm74 4861 23 arterial arterial JJ cord-015021-pol2qm74 4861 24 ( ( -LRB- cord-015021-pol2qm74 4861 25 a a DT cord-015021-pol2qm74 4861 26 ) ) -RRB- cord-015021-pol2qm74 4861 27 and and CC cord-015021-pol2qm74 4861 28 venous venous JJ cord-015021-pol2qm74 4861 29 ( ( -LRB- cord-015021-pol2qm74 4861 30 v v NN cord-015021-pol2qm74 4861 31 ) ) -RRB- cord-015021-pol2qm74 4861 32 blood blood NN cord-015021-pol2qm74 4861 33 samples sample NNS cord-015021-pol2qm74 4861 34 were be VBD cord-015021-pol2qm74 4861 35 obtained obtain VBN cord-015021-pol2qm74 4861 36 before before IN cord-015021-pol2qm74 4861 37 clamping clamp VBG cord-015021-pol2qm74 4861 38 and and CC cord-015021-pol2qm74 4861 39 declamping declampe VBG cord-015021-pol2qm74 4861 40 , , , cord-015021-pol2qm74 4861 41 and and CC cord-015021-pol2qm74 4861 42 60 60 CD cord-015021-pol2qm74 4861 43 min min NN cord-015021-pol2qm74 4861 44 after after IN cord-015021-pol2qm74 4861 45 declamping declampe VBG cord-015021-pol2qm74 4861 46 . . . cord-015021-pol2qm74 4862 1 Arterial arterial JJ cord-015021-pol2qm74 4862 2 PLA PLA NNP cord-015021-pol2qm74 4862 3 2 2 CD cord-015021-pol2qm74 4862 4 concentrations concentration NNS cord-015021-pol2qm74 4862 5 were be VBD cord-015021-pol2qm74 4862 6 higher high JJR cord-015021-pol2qm74 4862 7 than than IN cord-015021-pol2qm74 4862 8 venous venous JJ cord-015021-pol2qm74 4862 9 ( ( -LRB- cord-015021-pol2qm74 4862 10 113 113 CD cord-015021-pol2qm74 4862 11 + + SYM cord-015021-pol2qm74 4862 12 32 32 CD cord-015021-pol2qm74 4862 13 vs. vs. NN cord-015021-pol2qm74 4862 14 71 71 CD cord-015021-pol2qm74 4862 15 + + SYM cord-015021-pol2qm74 4862 16 30 30 CD cord-015021-pol2qm74 4862 17 ) ) -RRB- cord-015021-pol2qm74 4862 18 . . . cord-015021-pol2qm74 4863 1 While while IN cord-015021-pol2qm74 4863 2 cytosolic cytosolic JJ cord-015021-pol2qm74 4863 3 basal basal NN cord-015021-pol2qm74 4863 4 PMNL PMNL NNP cord-015021-pol2qm74 4864 1 Ca ca NN cord-015021-pol2qm74 4864 2 2 2 CD cord-015021-pol2qm74 4864 3 + + CD cord-015021-pol2qm74 4864 4 concenlxation concenlxation NN cord-015021-pol2qm74 4864 5 was be VBD cord-015021-pol2qm74 4864 6 not not RB cord-015021-pol2qm74 4864 7 altered alter VBN cord-015021-pol2qm74 4864 8 at at IN cord-015021-pol2qm74 4864 9 the the DT cord-015021-pol2qm74 4864 10 end end NN cord-015021-pol2qm74 4864 11 of of IN cord-015021-pol2qm74 4864 12 ischemia ischemia NN cord-015021-pol2qm74 4864 13 ( ( -LRB- cord-015021-pol2qm74 4864 14 v v NN cord-015021-pol2qm74 4864 15 : : : cord-015021-pol2qm74 4864 16 52.3 52.3 CD cord-015021-pol2qm74 4864 17 + + SYM cord-015021-pol2qm74 4864 18 8 8 CD cord-015021-pol2qm74 4864 19 ; ; : cord-015021-pol2qm74 4864 20 a a DT cord-015021-pol2qm74 4864 21 : : : cord-015021-pol2qm74 4864 22 42_+6 42_+6 CD cord-015021-pol2qm74 4864 23 ) ) -RRB- cord-015021-pol2qm74 4864 24 and and CC cord-015021-pol2qm74 4864 25 during during IN cord-015021-pol2qm74 4864 26 reperfusion reperfusion NN cord-015021-pol2qm74 4864 27 ( ( -LRB- cord-015021-pol2qm74 4864 28 v v NN cord-015021-pol2qm74 4864 29 : : : cord-015021-pol2qm74 4864 30 60 60 CD cord-015021-pol2qm74 4864 31 + + SYM cord-015021-pol2qm74 4864 32 8 8 CD cord-015021-pol2qm74 4864 33 ; ; : cord-015021-pol2qm74 4864 34 a a DT cord-015021-pol2qm74 4864 35 : : : cord-015021-pol2qm74 4864 36 69 69 CD cord-015021-pol2qm74 4864 37 + + SYM cord-015021-pol2qm74 4864 38 12 12 CD cord-015021-pol2qm74 4864 39 ) ) -RRB- cord-015021-pol2qm74 4864 40 , , , cord-015021-pol2qm74 4864 41 FMLP FMLP NNP cord-015021-pol2qm74 4864 42 - - HYPH cord-015021-pol2qm74 4864 43 stimulated stimulate VBN cord-015021-pol2qm74 4864 44 cytosolic cytosolic JJ cord-015021-pol2qm74 4865 1 Ca ca NN cord-015021-pol2qm74 4865 2 2 2 CD cord-015021-pol2qm74 4865 3 + + CD cord-015021-pol2qm74 4866 1 mobilization mobilization NN cord-015021-pol2qm74 4866 2 showed show VBD cord-015021-pol2qm74 4866 3 a a DT cord-015021-pol2qm74 4866 4 significant significant JJ cord-015021-pol2qm74 4866 5 arterial arterial JJ cord-015021-pol2qm74 4866 6 increase increase NN cord-015021-pol2qm74 4866 7 as as IN cord-015021-pol2qm74 4866 8 compared compare VBN cord-015021-pol2qm74 4866 9 to to IN cord-015021-pol2qm74 4866 10 venous venous JJ cord-015021-pol2qm74 4866 11 ( ( -LRB- cord-015021-pol2qm74 4866 12 1652_+601 1652_+601 CD cord-015021-pol2qm74 4866 13 vs. vs. IN cord-015021-pol2qm74 4866 14 638 638 CD cord-015021-pol2qm74 4866 15 + + SYM cord-015021-pol2qm74 4866 16 85 85 CD cord-015021-pol2qm74 4866 17 , , , cord-015021-pol2qm74 4866 18 p p NN cord-015021-pol2qm74 4866 19 < < XX cord-015021-pol2qm74 4866 20 .05 .05 NFP cord-015021-pol2qm74 4866 21 ) ) -RRB- cord-015021-pol2qm74 4866 22 . . . cord-015021-pol2qm74 4867 1 These these DT cord-015021-pol2qm74 4867 2 presented present VBN cord-015021-pol2qm74 4867 3 data datum NNS cord-015021-pol2qm74 4867 4 indicate indicate VBP cord-015021-pol2qm74 4867 5 that that IN cord-015021-pol2qm74 4867 6 the the DT cord-015021-pol2qm74 4867 7 reperfusion reperfusion NN cord-015021-pol2qm74 4867 8 syndrome syndrome NN cord-015021-pol2qm74 4867 9 after after IN cord-015021-pol2qm74 4867 10 infrarenal infrarenal JJ cord-015021-pol2qm74 4867 11 aortic aortic NNP cord-015021-pol2qm74 4867 12 clamping clamping NN cord-015021-pol2qm74 4867 13 is be VBZ cord-015021-pol2qm74 4867 14 characterized characterize VBN cord-015021-pol2qm74 4867 15 by by IN cord-015021-pol2qm74 4867 16 1 1 CD cord-015021-pol2qm74 4867 17 ) ) -RRB- cord-015021-pol2qm74 4867 18 pulmonary pulmonary JJ cord-015021-pol2qm74 4867 19 membrane membrane NN cord-015021-pol2qm74 4867 20 damage damage NN cord-015021-pol2qm74 4867 21 possibly possibly RB cord-015021-pol2qm74 4867 22 due due JJ cord-015021-pol2qm74 4867 23 to to IN cord-015021-pol2qm74 4867 24 PMNL PMNL NNP cord-015021-pol2qm74 4867 25 - - HYPH cord-015021-pol2qm74 4867 26 degranulation degranulation NN cord-015021-pol2qm74 4867 27 , , , cord-015021-pol2qm74 4867 28 2 2 CD cord-015021-pol2qm74 4867 29 ) ) -RRB- cord-015021-pol2qm74 4867 30 activation activation NN cord-015021-pol2qm74 4867 31 of of IN cord-015021-pol2qm74 4867 32 PMNL PMNL NNP cord-015021-pol2qm74 4867 33 - - HYPH cord-015021-pol2qm74 4867 34 superoxide superoxide NN cord-015021-pol2qm74 4867 35 radical radical JJ cord-015021-pol2qm74 4867 36 production production NN cord-015021-pol2qm74 4867 37 with with IN cord-015021-pol2qm74 4867 38 release release NN cord-015021-pol2qm74 4867 39 of of IN cord-015021-pol2qm74 4867 40 activated activate VBN cord-015021-pol2qm74 4867 41 PMNL PMNL NNP cord-015021-pol2qm74 4867 42 in in IN cord-015021-pol2qm74 4867 43 arterial arterial JJ cord-015021-pol2qm74 4867 44 circulation circulation NN cord-015021-pol2qm74 4867 45 , , , cord-015021-pol2qm74 4867 46 and and CC cord-015021-pol2qm74 4867 47 3 3 LS cord-015021-pol2qm74 4867 48 ) ) -RRB- cord-015021-pol2qm74 4868 1 a a DT cord-015021-pol2qm74 4868 2 significant significant JJ cord-015021-pol2qm74 4868 3 arterial arterial JJ cord-015021-pol2qm74 4868 4 increase increase NN cord-015021-pol2qm74 4868 5 of of IN cord-015021-pol2qm74 4868 6 PMNL PMNL NNP cord-015021-pol2qm74 4868 7 cytosolic cytosolic JJ cord-015021-pol2qm74 4869 1 Ca ca NN cord-015021-pol2qm74 4869 2 2 2 CD cord-015021-pol2qm74 4869 3 + + CC cord-015021-pol2qm74 4869 4 mobilization mobilization NN cord-015021-pol2qm74 4869 5 after after IN cord-015021-pol2qm74 4869 6 FMLP FMLP NNP cord-015021-pol2qm74 4869 7 - - HYPH cord-015021-pol2qm74 4869 8 stimulation stimulation NN cord-015021-pol2qm74 4869 9 parallel parallel NN cord-015021-pol2qm74 4869 10 to to IN cord-015021-pol2qm74 4869 11 PMNL PMNL NNP cord-015021-pol2qm74 4869 12 - - HYPH cord-015021-pol2qm74 4869 13 activation activation NN cord-015021-pol2qm74 4869 14 . . . cord-015021-pol2qm74 4870 1 In in IN cord-015021-pol2qm74 4870 2 conclusion conclusion NN cord-015021-pol2qm74 4870 3 , , , cord-015021-pol2qm74 4870 4 ischemia ischemia NN cord-015021-pol2qm74 4870 5 / / SYM cord-015021-pol2qm74 4870 6 reperfusion reperfusion NN cord-015021-pol2qm74 4870 7 in in IN cord-015021-pol2qm74 4870 8 man man NN cord-015021-pol2qm74 4870 9 induces induce VBZ cord-015021-pol2qm74 4870 10 pulmonary pulmonary JJ cord-015021-pol2qm74 4870 11 damage damage NN cord-015021-pol2qm74 4870 12 and and CC cord-015021-pol2qm74 4870 13 activation activation NN cord-015021-pol2qm74 4870 14 of of IN cord-015021-pol2qm74 4870 15 PMNL PMNL NNP cord-015021-pol2qm74 4870 16 superoxide superoxide NN cord-015021-pol2qm74 4870 17 production production NN cord-015021-pol2qm74 4870 18 possibly possibly RB cord-015021-pol2qm74 4870 19 due due IN cord-015021-pol2qm74 4870 20 to to IN cord-015021-pol2qm74 4870 21 an an DT cord-015021-pol2qm74 4870 22 altered altered JJ cord-015021-pol2qm74 4870 23 PMNL- pmnl- NN cord-015021-pol2qm74 4871 1 Ca ca NN cord-015021-pol2qm74 4871 2 2 2 CD cord-015021-pol2qm74 4871 3 + + CC cord-015021-pol2qm74 4871 4 messenger messenger NN cord-015021-pol2qm74 4871 5 system system NN cord-015021-pol2qm74 4871 6 by by IN cord-015021-pol2qm74 4871 7 inflammatory inflammatory JJ cord-015021-pol2qm74 4871 8 mediators mediator NNS cord-015021-pol2qm74 4871 9 ( ( -LRB- cord-015021-pol2qm74 4871 10 e e NN cord-015021-pol2qm74 4871 11 , , , cord-015021-pol2qm74 4871 12 g g NN cord-015021-pol2qm74 4871 13 . . . cord-015021-pol2qm74 4871 14 II-8 II-8 NNP cord-015021-pol2qm74 4871 15 , , , cord-015021-pol2qm74 4871 16 TNF TNF NNP cord-015021-pol2qm74 4871 17 , , , cord-015021-pol2qm74 4871 18 PAF PAF NNP cord-015021-pol2qm74 4871 19 ) ) -RRB- cord-015021-pol2qm74 4871 20 . . . cord-015021-pol2qm74 4872 1 The the DT cord-015021-pol2qm74 4872 2 septic septic JJ cord-015021-pol2qm74 4872 3 lung lung NN cord-015021-pol2qm74 4872 4 diseases disease NNS cord-015021-pol2qm74 4872 5 ( ( -LRB- cord-015021-pol2qm74 4872 6 i.e. i.e. FW cord-015021-pol2qm74 4872 7 ARDS ARDS NNP cord-015021-pol2qm74 4872 8 ) ) -RRB- cord-015021-pol2qm74 4872 9 generally generally RB cord-015021-pol2qm74 4872 10 show show VBP cord-015021-pol2qm74 4872 11 distinct distinct JJ cord-015021-pol2qm74 4872 12 alveolar alveolar JJ cord-015021-pol2qm74 4872 13 damage damage NN cord-015021-pol2qm74 4872 14 and and CC cord-015021-pol2qm74 4872 15 surfactant surfactant NN cord-015021-pol2qm74 4872 16 disturbances disturbance NNS cord-015021-pol2qm74 4872 17 . . . cord-015021-pol2qm74 4873 1 It -PRON- PRP cord-015021-pol2qm74 4873 2 is be VBZ cord-015021-pol2qm74 4873 3 thought think VBN cord-015021-pol2qm74 4873 4 that that IN cord-015021-pol2qm74 4873 5 alveolar alveolar JJ cord-015021-pol2qm74 4873 6 macrophages macrophage NNS cord-015021-pol2qm74 4873 7 are be VBP cord-015021-pol2qm74 4873 8 involved involve VBN cord-015021-pol2qm74 4873 9 in in IN cord-015021-pol2qm74 4873 10 specific specific JJ cord-015021-pol2qm74 4873 11 release release NN cord-015021-pol2qm74 4873 12 products product NNS cord-015021-pol2qm74 4873 13 like like IN cord-015021-pol2qm74 4873 14 H202 H202 NNS cord-015021-pol2qm74 4873 15 and and CC cord-015021-pol2qm74 4873 16 cytokines cytokine NNS cord-015021-pol2qm74 4873 17 like like IN cord-015021-pol2qm74 4873 18 TNF TNF NNP cord-015021-pol2qm74 4873 19 . . . cord-015021-pol2qm74 4874 1 In in IN cord-015021-pol2qm74 4874 2 this this DT cord-015021-pol2qm74 4874 3 pathway pathway NN cord-015021-pol2qm74 4874 4 the the DT cord-015021-pol2qm74 4874 5 type type NN cord-015021-pol2qm74 4874 6 II ii CD cord-015021-pol2qm74 4874 7 alveolar alveolar NN cord-015021-pol2qm74 4874 8 epithelial epithelial JJ cord-015021-pol2qm74 4874 9 cell cell NN cord-015021-pol2qm74 4874 10 ( ( -LRB- cord-015021-pol2qm74 4874 11 P2 p2 NN cord-015021-pol2qm74 4874 12 cell cell NN cord-015021-pol2qm74 4874 13 ) ) -RRB- cord-015021-pol2qm74 4874 14 is be VBZ cord-015021-pol2qm74 4874 15 not not RB cord-015021-pol2qm74 4874 16 only only RB cord-015021-pol2qm74 4874 17 an an DT cord-015021-pol2qm74 4874 18 important important JJ cord-015021-pol2qm74 4874 19 target target NN cord-015021-pol2qm74 4874 20 , , , cord-015021-pol2qm74 4874 21 but but CC cord-015021-pol2qm74 4874 22 as as IN cord-015021-pol2qm74 4874 23 recently recently RB cord-015021-pol2qm74 4874 24 shown show VBN cord-015021-pol2qm74 4874 25 it -PRON- PRP cord-015021-pol2qm74 4874 26 is be VBZ cord-015021-pol2qm74 4874 27 also also RB cord-015021-pol2qm74 4874 28 capable capable JJ cord-015021-pol2qm74 4874 29 of of IN cord-015021-pol2qm74 4874 30 producing produce VBG cord-015021-pol2qm74 4874 31 H202 H202 NNS cord-015021-pol2qm74 4874 32 . . . cord-015021-pol2qm74 4875 1 The the DT cord-015021-pol2qm74 4875 2 aim aim NN cord-015021-pol2qm74 4875 3 of of IN cord-015021-pol2qm74 4875 4 this this DT cord-015021-pol2qm74 4875 5 study study NN cord-015021-pol2qm74 4875 6 was be VBD cord-015021-pol2qm74 4875 7 to to TO cord-015021-pol2qm74 4875 8 investigate investigate VB cord-015021-pol2qm74 4875 9 the the DT cord-015021-pol2qm74 4875 10 influence influence NN cord-015021-pol2qm74 4875 11 of of IN cord-015021-pol2qm74 4875 12 endotoxin endotoxin NN cord-015021-pol2qm74 4875 13 on on IN cord-015021-pol2qm74 4875 14 H202 h202 NN cord-015021-pol2qm74 4875 15 release release NN cord-015021-pol2qm74 4875 16 of of IN cord-015021-pol2qm74 4875 17 P2 P2 NNP cord-015021-pol2qm74 4875 18 cells cell NNS cord-015021-pol2qm74 4875 19 . . . cord-015021-pol2qm74 4876 1 We -PRON- PRP cord-015021-pol2qm74 4876 2 obtained obtain VBD cord-015021-pol2qm74 4876 3 P2 P2 NNP cord-015021-pol2qm74 4876 4 cells cell NNS cord-015021-pol2qm74 4876 5 from from IN cord-015021-pol2qm74 4876 6 lungs lung NNS cord-015021-pol2qm74 4876 7 of of IN cord-015021-pol2qm74 4876 8 female female JJ cord-015021-pol2qm74 4876 9 wistar wistar NNP cord-015021-pol2qm74 4876 10 rats rat NNS cord-015021-pol2qm74 4876 11 and and CC cord-015021-pol2qm74 4876 12 investigated investigate VBD cord-015021-pol2qm74 4876 13 the the DT cord-015021-pol2qm74 4876 14 effect effect NN cord-015021-pol2qm74 4876 15 of of IN cord-015021-pol2qm74 4876 16 lipopolysaccharid lipopolysaccharid NNP cord-015021-pol2qm74 4876 17 ( ( -LRB- cord-015021-pol2qm74 4876 18 LPS LPS NNP cord-015021-pol2qm74 4876 19 ) ) -RRB- cord-015021-pol2qm74 4876 20 on on IN cord-015021-pol2qm74 4876 21 H202 h202 NN cord-015021-pol2qm74 4876 22 release release NN cord-015021-pol2qm74 4876 23 of of IN cord-015021-pol2qm74 4876 24 fresh fresh JJ cord-015021-pol2qm74 4876 25 isolated isolated JJ cord-015021-pol2qm74 4876 26 cells cell NNS cord-015021-pol2qm74 4876 27 and and CC cord-015021-pol2qm74 4876 28 on on IN cord-015021-pol2qm74 4876 29 cells cell NNS cord-015021-pol2qm74 4876 30 cultured culture VBN cord-015021-pol2qm74 4876 31 for for IN cord-015021-pol2qm74 4876 32 2 2 CD cord-015021-pol2qm74 4876 33 days day NNS cord-015021-pol2qm74 4876 34 in in IN cord-015021-pol2qm74 4876 35 a a DT cord-015021-pol2qm74 4876 36 fibronectin fibronectin NN cord-015021-pol2qm74 4876 37 matrix matrix NN cord-015021-pol2qm74 4876 38 . . . cord-015021-pol2qm74 4877 1 Furthermore furthermore RB cord-015021-pol2qm74 4877 2 we -PRON- PRP cord-015021-pol2qm74 4877 3 conditioned condition VBD cord-015021-pol2qm74 4877 4 isolated isolated JJ cord-015021-pol2qm74 4877 5 alveolar alveolar JJ cord-015021-pol2qm74 4877 6 macrophages macrophage NNS cord-015021-pol2qm74 4877 7 for for IN cord-015021-pol2qm74 4877 8 16 16 CD cord-015021-pol2qm74 4877 9 hours hour NNS cord-015021-pol2qm74 4877 10 with with IN cord-015021-pol2qm74 4877 11 1 1 CD cord-015021-pol2qm74 4877 12 p.g p.g NNP cord-015021-pol2qm74 4877 13 / / SYM cord-015021-pol2qm74 4877 14 ml ml NNP cord-015021-pol2qm74 4877 15 LPS LPS NNP cord-015021-pol2qm74 4877 16 and and CC cord-015021-pol2qm74 4877 17 tested test VBD cord-015021-pol2qm74 4877 18 the the DT cord-015021-pol2qm74 4877 19 conditioned condition VBN cord-015021-pol2qm74 4877 20 medium medium NN cord-015021-pol2qm74 4877 21 ( ( -LRB- cord-015021-pol2qm74 4877 22 MCM MCM NNP cord-015021-pol2qm74 4877 23 ) ) -RRB- cord-015021-pol2qm74 4877 24 on on IN cord-015021-pol2qm74 4877 25 cultured cultured JJ cord-015021-pol2qm74 4877 26 P2 P2 NNP cord-015021-pol2qm74 4877 27 cells cell NNS cord-015021-pol2qm74 4877 28 . . . cord-015021-pol2qm74 4878 1 P2 p2 NN cord-015021-pol2qm74 4878 2 cells cell NNS cord-015021-pol2qm74 4878 3 5 5 CD cord-015021-pol2qm74 4878 4 h h NN cord-015021-pol2qm74 4879 1 ex ex NNP cord-015021-pol2qm74 4879 2 vivo vivo NNP cord-015021-pol2qm74 4879 3 were be VBD cord-015021-pol2qm74 4879 4 _ _ NN cord-015021-pol2qm74 4879 5 > > XX cord-015021-pol2qm74 4880 1 70 70 CD cord-015021-pol2qm74 4880 2 % % NN cord-015021-pol2qm74 4880 3 pure pure JJ cord-015021-pol2qm74 4880 4 , , , cord-015021-pol2qm74 4880 5 _ _ NN cord-015021-pol2qm74 4880 6 > > XX cord-015021-pol2qm74 4880 7 95 95 CD cord-015021-pol2qm74 4880 8 % % NN cord-015021-pol2qm74 4880 9 vital vital JJ cord-015021-pol2qm74 4880 10 and and CC cord-015021-pol2qm74 4880 11 had have VBD cord-015021-pol2qm74 4880 12 an an DT cord-015021-pol2qm74 4880 13 basal basal NN cord-015021-pol2qm74 4880 14 H202 h202 NN cord-015021-pol2qm74 4880 15 release release NN cord-015021-pol2qm74 4880 16 of of IN cord-015021-pol2qm74 4880 17 64.5 64.5 CD cord-015021-pol2qm74 4880 18 _ _ NN cord-015021-pol2qm74 4880 19 + + CC cord-015021-pol2qm74 4881 1 1.8 1.8 CD cord-015021-pol2qm74 4881 2 nmol nmol JJ cord-015021-pol2qm74 4881 3 H202 h202 NN cord-015021-pol2qm74 4881 4 per per IN cord-015021-pol2qm74 4881 5 hour hour NN cord-015021-pol2qm74 4881 6 and and CC cord-015021-pol2qm74 4881 7 million million CD cord-015021-pol2qm74 4881 8 cells cell NNS cord-015021-pol2qm74 4881 9 . . . cord-015021-pol2qm74 4882 1 Adding add VBG cord-015021-pol2qm74 4882 2 1 1 CD cord-015021-pol2qm74 4882 3 p.g p.g NNP cord-015021-pol2qm74 4882 4 / / SYM cord-015021-pol2qm74 4882 5 ml ml IN cord-015021-pol2qm74 4882 6 LPS LPS NNP cord-015021-pol2qm74 4882 7 to to IN cord-015021-pol2qm74 4882 8 the the DT cord-015021-pol2qm74 4882 9 incubation incubation NN cord-015021-pol2qm74 4882 10 medium medium NN cord-015021-pol2qm74 4882 11 the the DT cord-015021-pol2qm74 4882 12 H202 h202 NN cord-015021-pol2qm74 4882 13 release release NN cord-015021-pol2qm74 4882 14 decreases decrease VBZ cord-015021-pol2qm74 4882 15 slightly slightly RB cord-015021-pol2qm74 4882 16 but but CC cord-015021-pol2qm74 4882 17 significantly significantly RB cord-015021-pol2qm74 4882 18 to to IN cord-015021-pol2qm74 4882 19 54.2 54.2 CD cord-015021-pol2qm74 4882 20 _ _ NN cord-015021-pol2qm74 4882 21 + + SYM cord-015021-pol2qm74 4882 22 2.3 2.3 CD cord-015021-pol2qm74 4882 23 nmol nmol NN cord-015021-pol2qm74 4882 24 . . . cord-015021-pol2qm74 4883 1 Adding add VBG cord-015021-pol2qm74 4883 2 0.3 0.3 CD cord-015021-pol2qm74 4883 3 p.g p.g NNP cord-015021-pol2qm74 4883 4 / / SYM cord-015021-pol2qm74 4883 5 ml ml NNP cord-015021-pol2qm74 4883 6 phorbol phorbol NNP cord-015021-pol2qm74 4883 7 myristate myristate NNP cord-015021-pol2qm74 4883 8 acetate acetate NNP cord-015021-pol2qm74 4883 9 ( ( -LRB- cord-015021-pol2qm74 4883 10 PMA PMA NNP cord-015021-pol2qm74 4883 11 ) ) -RRB- cord-015021-pol2qm74 4883 12 to to IN cord-015021-pol2qm74 4883 13 the the DT cord-015021-pol2qm74 4883 14 basal basal NN cord-015021-pol2qm74 4883 15 incubation incubation NN cord-015021-pol2qm74 4883 16 medium medium NN cord-015021-pol2qm74 4884 1 the the DT cord-015021-pol2qm74 4884 2 H202 H202 NNP cord-015021-pol2qm74 4884 3 release release NN cord-015021-pol2qm74 4884 4 increased increase VBD cord-015021-pol2qm74 4884 5 3-fold 3-fold CD cord-015021-pol2qm74 4884 6 to to IN cord-015021-pol2qm74 4884 7 148.3_+ 148.3_+ CD cord-015021-pol2qm74 4884 8 26 26 CD cord-015021-pol2qm74 4884 9 nmol nmol NN cord-015021-pol2qm74 4884 10 . . . cord-015021-pol2qm74 4885 1 PMA PMA NNP cord-015021-pol2qm74 4885 2 induced induce VBD cord-015021-pol2qm74 4885 3 H202 h202 NN cord-015021-pol2qm74 4885 4 release release NN cord-015021-pol2qm74 4885 5 decreased decrease VBD cord-015021-pol2qm74 4885 6 to to IN cord-015021-pol2qm74 4885 7 128.3 128.3 CD cord-015021-pol2qm74 4885 8 + + SYM cord-015021-pol2qm74 4885 9 41.5 41.5 CD cord-015021-pol2qm74 4885 10 nmol nmol NN cord-015021-pol2qm74 4885 11 after after IN cord-015021-pol2qm74 4885 12 addition addition NN cord-015021-pol2qm74 4885 13 of of IN cord-015021-pol2qm74 4885 14 1 1 CD cord-015021-pol2qm74 4885 15 p.g p.g NNP cord-015021-pol2qm74 4885 16 / / SYM cord-015021-pol2qm74 4885 17 ml ml NN cord-015021-pol2qm74 4885 18 LPS lp NNS cord-015021-pol2qm74 4885 19 . . . cord-015021-pol2qm74 4886 1 After after IN cord-015021-pol2qm74 4886 2 2 2 CD cord-015021-pol2qm74 4886 3 culture culture NN cord-015021-pol2qm74 4886 4 days day NNS cord-015021-pol2qm74 4886 5 the the DT cord-015021-pol2qm74 4886 6 P2 P2 NNP cord-015021-pol2qm74 4886 7 cells cell NNS cord-015021-pol2qm74 4886 8 were be VBD cord-015021-pol2qm74 4886 9 _ _ NN cord-015021-pol2qm74 4886 10 > > XX cord-015021-pol2qm74 4886 11 98 98 CD cord-015021-pol2qm74 4886 12 % % NN cord-015021-pol2qm74 4886 13 pure pure JJ cord-015021-pol2qm74 4886 14 and and CC cord-015021-pol2qm74 4886 15 showed show VBD cord-015021-pol2qm74 4886 16 a a DT cord-015021-pol2qm74 4886 17 PMA PMA NNP cord-015021-pol2qm74 4886 18 inducible inducible JJ cord-015021-pol2qm74 4886 19 H202 h202 NN cord-015021-pol2qm74 4886 20 release release NN cord-015021-pol2qm74 4886 21 of of IN cord-015021-pol2qm74 4887 1 174.8 174.8 CD cord-015021-pol2qm74 4887 2 _ _ NN cord-015021-pol2qm74 4887 3 + + SYM cord-015021-pol2qm74 4887 4 9.9 9.9 CD cord-015021-pol2qm74 4887 5 nmoL nmol CD cord-015021-pol2qm74 4888 1 Addition addition NN cord-015021-pol2qm74 4888 2 of of IN cord-015021-pol2qm74 4888 3 1 1 CD cord-015021-pol2qm74 4889 1 p.g p.g NNP cord-015021-pol2qm74 4889 2 / / SYM cord-015021-pol2qm74 4889 3 ml ml NNP cord-015021-pol2qm74 4889 4 LPS LPS NNP cord-015021-pol2qm74 4889 5 had have VBD cord-015021-pol2qm74 4889 6 the the DT cord-015021-pol2qm74 4889 7 inverse inverse JJ cord-015021-pol2qm74 4889 8 effect effect NN cord-015021-pol2qm74 4889 9 as as IN cord-015021-pol2qm74 4889 10 on on IN cord-015021-pol2qm74 4889 11 freshly freshly RB cord-015021-pol2qm74 4889 12 isolated isolate VBN cord-015021-pol2qm74 4889 13 cells cell NNS cord-015021-pol2qm74 4889 14 as as IN cord-015021-pol2qm74 4889 15 it -PRON- PRP cord-015021-pol2qm74 4889 16 increased increase VBD cord-015021-pol2qm74 4889 17 the the DT cord-015021-pol2qm74 4889 18 H202 h202 NN cord-015021-pol2qm74 4889 19 release release NN cord-015021-pol2qm74 4889 20 up up RP cord-015021-pol2qm74 4889 21 to to IN cord-015021-pol2qm74 4890 1 216.2 216.2 CD cord-015021-pol2qm74 4890 2 _ _ NN cord-015021-pol2qm74 4890 3 + + SYM cord-015021-pol2qm74 4890 4 2.4 2.4 CD cord-015021-pol2qm74 4890 5 nmol nmol NN cord-015021-pol2qm74 4890 6 . . . cord-015021-pol2qm74 4891 1 Addition addition NN cord-015021-pol2qm74 4891 2 of of IN cord-015021-pol2qm74 4891 3 MCM MCM NNP cord-015021-pol2qm74 4891 4 to to IN cord-015021-pol2qm74 4891 5 cultured cultured JJ cord-015021-pol2qm74 4891 6 P2 P2 NNP cord-015021-pol2qm74 4891 7 cells cell NNS cord-015021-pol2qm74 4891 8 increases increase VBZ cord-015021-pol2qm74 4891 9 PMA PMA NNP cord-015021-pol2qm74 4891 10 - - HYPH cord-015021-pol2qm74 4891 11 stimulated stimulate VBN cord-015021-pol2qm74 4891 12 H202 h202 NN cord-015021-pol2qm74 4891 13 release release NN cord-015021-pol2qm74 4891 14 to to IN cord-015021-pol2qm74 4891 15 223.3 223.3 CD cord-015021-pol2qm74 4891 16 + + CC cord-015021-pol2qm74 4891 17 _ _ NN cord-015021-pol2qm74 4891 18 10.7 10.7 CD cord-015021-pol2qm74 4891 19 nmol nmol NN cord-015021-pol2qm74 4891 20 . . . cord-015021-pol2qm74 4892 1 The the DT cord-015021-pol2qm74 4892 2 release release NN cord-015021-pol2qm74 4892 3 decreased decrease VBD cord-015021-pol2qm74 4892 4 to to IN cord-015021-pol2qm74 4892 5 191.9 191.9 CD cord-015021-pol2qm74 4892 6 _ _ NN cord-015021-pol2qm74 4892 7 + + SYM cord-015021-pol2qm74 4892 8 2.4 2.4 CD cord-015021-pol2qm74 4892 9 nmol nmol NN cord-015021-pol2qm74 4892 10 when when WRB cord-015021-pol2qm74 4892 11 an an DT cord-015021-pol2qm74 4892 12 murine murine JJ cord-015021-pol2qm74 4892 13 anti anti JJ cord-015021-pol2qm74 4892 14 - - JJ cord-015021-pol2qm74 4892 15 TNF tnf JJ cord-015021-pol2qm74 4892 16 - - HYPH cord-015021-pol2qm74 4892 17 alpha alpha NN cord-015021-pol2qm74 4892 18 antibody antibody NN cord-015021-pol2qm74 4892 19 was be VBD cord-015021-pol2qm74 4892 20 added add VBN cord-015021-pol2qm74 4892 21 . . . cord-015021-pol2qm74 4893 1 Vitality vitality NN cord-015021-pol2qm74 4893 2 of of IN cord-015021-pol2qm74 4893 3 cultured cultured JJ cord-015021-pol2qm74 4893 4 cells cell NNS cord-015021-pol2qm74 4893 5 was be VBD cord-015021-pol2qm74 4893 6 > > : cord-015021-pol2qm74 4893 7 96 96 CD cord-015021-pol2qm74 4893 8 % % NN cord-015021-pol2qm74 4893 9 in in IN cord-015021-pol2qm74 4893 10 all all DT cord-015021-pol2qm74 4893 11 experiments experiment NNS cord-015021-pol2qm74 4893 12 . . . cord-015021-pol2qm74 4894 1 The the DT cord-015021-pol2qm74 4894 2 results result NNS cord-015021-pol2qm74 4894 3 show show VBP cord-015021-pol2qm74 4894 4 that that IN cord-015021-pol2qm74 4894 5 LPS LPS NNP cord-015021-pol2qm74 4894 6 has have VBZ cord-015021-pol2qm74 4894 7 an an DT cord-015021-pol2qm74 4894 8 direct direct JJ cord-015021-pol2qm74 4894 9 effect effect NN cord-015021-pol2qm74 4894 10 on on IN cord-015021-pol2qm74 4894 11 P2 P2 NNP cord-015021-pol2qm74 4894 12 cells cell NNS cord-015021-pol2qm74 4894 13 cultured culture VBN cord-015021-pol2qm74 4894 14 on on IN cord-015021-pol2qm74 4894 15 fibronectin fibronectin NN cord-015021-pol2qm74 4894 16 . . . cord-015021-pol2qm74 4895 1 We -PRON- PRP cord-015021-pol2qm74 4895 2 conclude conclude VBP cord-015021-pol2qm74 4895 3 that that IN cord-015021-pol2qm74 4895 4 the the DT cord-015021-pol2qm74 4895 5 observed observed JJ cord-015021-pol2qm74 4895 6 additional additional JJ cord-015021-pol2qm74 4895 7 stimulatory stimulatory JJ cord-015021-pol2qm74 4895 8 effects effect NNS cord-015021-pol2qm74 4895 9 of of IN cord-015021-pol2qm74 4895 10 MCM MCM NNP cord-015021-pol2qm74 4895 11 seems seem VBZ cord-015021-pol2qm74 4895 12 to to TO cord-015021-pol2qm74 4895 13 depend depend VB cord-015021-pol2qm74 4895 14 on on IN cord-015021-pol2qm74 4895 15 TNF TNF NNP cord-015021-pol2qm74 4895 16 - - HYPH cord-015021-pol2qm74 4895 17 alpha alpha NN cord-015021-pol2qm74 4895 18 . . . cord-015021-pol2qm74 4896 1 The the DT cord-015021-pol2qm74 4896 2 induction induction NN cord-015021-pol2qm74 4896 3 of of IN cord-015021-pol2qm74 4896 4 H202 H202 NNP cord-015021-pol2qm74 4896 5 release release NN cord-015021-pol2qm74 4896 6 of of IN cord-015021-pol2qm74 4896 7 P2 P2 NNP cord-015021-pol2qm74 4896 8 cells cell NNS cord-015021-pol2qm74 4896 9 could could MD cord-015021-pol2qm74 4896 10 be be VB cord-015021-pol2qm74 4896 11 important important JJ cord-015021-pol2qm74 4896 12 for for IN cord-015021-pol2qm74 4896 13 generating generate VBG cord-015021-pol2qm74 4896 14 internal internal JJ cord-015021-pol2qm74 4896 15 oxidative oxidative JJ cord-015021-pol2qm74 4896 16 stress stress NN cord-015021-pol2qm74 4896 17 in in IN cord-015021-pol2qm74 4896 18 P2 P2 NNP cord-015021-pol2qm74 4896 19 cells cell NNS cord-015021-pol2qm74 4896 20 before before IN cord-015021-pol2qm74 4896 21 external external JJ cord-015021-pol2qm74 4896 22 oxygen oxygen NN cord-015021-pol2qm74 4896 23 radicals radical NNS cord-015021-pol2qm74 4896 24 exceed exceed VBP cord-015021-pol2qm74 4896 25 . . . cord-015021-pol2qm74 4897 1 The the DT cord-015021-pol2qm74 4897 2 produced produce VBN cord-015021-pol2qm74 4897 3 H202 h202 NN cord-015021-pol2qm74 4897 4 did do VBD cord-015021-pol2qm74 4897 5 not not RB cord-015021-pol2qm74 4897 6 necessarily necessarily RB cord-015021-pol2qm74 4897 7 damage damage VB cord-015021-pol2qm74 4897 8 P2 P2 NNP cord-015021-pol2qm74 4897 9 ceils ceil NNS cord-015021-pol2qm74 4897 10 , , , cord-015021-pol2qm74 4897 11 but but CC cord-015021-pol2qm74 4897 12 it -PRON- PRP cord-015021-pol2qm74 4897 13 can can MD cord-015021-pol2qm74 4897 14 effect effect VB cord-015021-pol2qm74 4897 15 surfactant surfactant NN cord-015021-pol2qm74 4897 16 metabolism metabolism NN cord-015021-pol2qm74 4897 17 , , , cord-015021-pol2qm74 4897 18 especially especially RB cord-015021-pol2qm74 4897 19 when when WRB cord-015021-pol2qm74 4897 20 extracellular extracellular JJ cord-015021-pol2qm74 4897 21 H202 h202 NN cord-015021-pol2qm74 4897 22 release release NN cord-015021-pol2qm74 4897 23 of of IN cord-015021-pol2qm74 4897 24 alveolar alveolar JJ cord-015021-pol2qm74 4897 25 macrophages macrophage NNS cord-015021-pol2qm74 4897 26 following follow VBG cord-015021-pol2qm74 4897 27 an an DT cord-015021-pol2qm74 4897 28 immune immune JJ cord-015021-pol2qm74 4897 29 response response NN cord-015021-pol2qm74 4897 30 is be VBZ cord-015021-pol2qm74 4897 31 increasing increase VBG cord-015021-pol2qm74 4897 32 . . . cord-015021-pol2qm74 4898 1 INTRODUCTION introduction NN cord-015021-pol2qm74 4898 2 : : : cord-015021-pol2qm74 4899 1 Primary primary JJ cord-015021-pol2qm74 4899 2 stabilization stabilization NN cord-015021-pol2qm74 4899 3 of of IN cord-015021-pol2qm74 4899 4 femoral femoral JJ cord-015021-pol2qm74 4899 5 shaft shaft NN cord-015021-pol2qm74 4899 6 fractures fracture NNS cord-015021-pol2qm74 4899 7 in in IN cord-015021-pol2qm74 4899 8 patients patient NNS cord-015021-pol2qm74 4899 9 with with IN cord-015021-pol2qm74 4899 10 multiple multiple JJ cord-015021-pol2qm74 4899 11 trauma trauma NN cord-015021-pol2qm74 4899 12 is be VBZ cord-015021-pol2qm74 4899 13 beneficial beneficial JJ cord-015021-pol2qm74 4899 14 . . . cord-015021-pol2qm74 4900 1 However however RB cord-015021-pol2qm74 4900 2 , , , cord-015021-pol2qm74 4900 3 in in IN cord-015021-pol2qm74 4900 4 patients patient NNS cord-015021-pol2qm74 4900 5 with with IN cord-015021-pol2qm74 4900 6 associated associated JJ cord-015021-pol2qm74 4900 7 lung lung NN cord-015021-pol2qm74 4900 8 contusion contusion NN cord-015021-pol2qm74 4900 9 we -PRON- PRP cord-015021-pol2qm74 4900 10 have have VBP cord-015021-pol2qm74 4900 11 found find VBN cord-015021-pol2qm74 4900 12 an an DT cord-015021-pol2qm74 4900 13 increased increase VBN cord-015021-pol2qm74 4900 14 incidence incidence NN cord-015021-pol2qm74 4900 15 of of IN cord-015021-pol2qm74 4900 16 ARDS ARDS NNP cord-015021-pol2qm74 4900 17 , , , cord-015021-pol2qm74 4900 18 apparently apparently RB cord-015021-pol2qm74 4900 19 associated associate VBN cord-015021-pol2qm74 4900 20 with with IN cord-015021-pol2qm74 4900 21 primary primary JJ cord-015021-pol2qm74 4900 22 Reamed Reamed NNP cord-015021-pol2qm74 4900 23 Femnral Femnral NNP cord-015021-pol2qm74 4900 24 Nailing nailing NN cord-015021-pol2qm74 4900 25 ( ( -LRB- cord-015021-pol2qm74 4900 26 RFN RFN NNP cord-015021-pol2qm74 4900 27 ) ) -RRB- cord-015021-pol2qm74 4900 28 . . . cord-015021-pol2qm74 4901 1 Previous previous JJ cord-015021-pol2qm74 4901 2 animal animal NN cord-015021-pol2qm74 4901 3 studies study NNS cord-015021-pol2qm74 4901 4 revealed reveal VBD cord-015021-pol2qm74 4901 5 , , , cord-015021-pol2qm74 4901 6 that that IN cord-015021-pol2qm74 4901 7 perioperative perioperative JJ cord-015021-pol2qm74 4901 8 disturbances disturbance NNS cord-015021-pol2qm74 4901 9 of of IN cord-015021-pol2qm74 4901 10 lung lung NN cord-015021-pol2qm74 4901 11 ftmetion ftmetion NN cord-015021-pol2qm74 4901 12 appear appear VBP cord-015021-pol2qm74 4901 13 to to TO cord-015021-pol2qm74 4901 14 be be VB cord-015021-pol2qm74 4901 15 related relate VBN cord-015021-pol2qm74 4901 16 to to IN cord-015021-pol2qm74 4901 17 the the DT cord-015021-pol2qm74 4901 18 reaming reaming NN cord-015021-pol2qm74 4901 19 procedure procedure NN cord-015021-pol2qm74 4901 20 , , , cord-015021-pol2qm74 4901 21 IX IX NNP cord-015021-pol2qm74 4901 22 ~ ~ NFP cord-015021-pol2qm74 4901 23 ssibly ssibly NNP cord-015021-pol2qm74 4901 24 due due JJ cord-015021-pol2qm74 4901 25 to to IN cord-015021-pol2qm74 4901 26 pulmonary pulmonary JJ cord-015021-pol2qm74 4901 27 embolizafion embolizafion NN cord-015021-pol2qm74 4901 28 of of IN cord-015021-pol2qm74 4901 29 bone bone NN cord-015021-pol2qm74 4901 30 marrow marrow NN cord-015021-pol2qm74 4901 31 fat fat NN cord-015021-pol2qm74 4901 32 . . . cord-015021-pol2qm74 4902 1 In in IN cord-015021-pol2qm74 4902 2 a a DT cord-015021-pol2qm74 4902 3 prospective prospective JJ cord-015021-pol2qm74 4902 4 clinical clinical JJ cord-015021-pol2qm74 4902 5 analysis analysis NN cord-015021-pol2qm74 4902 6 we -PRON- PRP cord-015021-pol2qm74 4902 7 compared compare VBD cord-015021-pol2qm74 4902 8 effects effect NNS cord-015021-pol2qm74 4902 9 of of IN cord-015021-pol2qm74 4902 10 intrameduUary intrameduuary JJ cord-015021-pol2qm74 4902 11 nailing nail VBG cord-015021-pol2qm74 4902 12 with with IN cord-015021-pol2qm74 4902 13 and and CC cord-015021-pol2qm74 4902 14 withont withont JJ cord-015021-pol2qm74 4902 15 reaming reaming NN cord-015021-pol2qm74 4902 16 on on IN cord-015021-pol2qm74 4902 17 parameters parameter NNS cord-015021-pol2qm74 4902 18 known know VBN cord-015021-pol2qm74 4902 19 to to TO cord-015021-pol2qm74 4902 20 be be VB cord-015021-pol2qm74 4902 21 related relate VBN cord-015021-pol2qm74 4902 22 to to IN cord-015021-pol2qm74 4902 23 ARDS ARDS NNP cord-015021-pol2qm74 4902 24 - - HYPH cord-015021-pol2qm74 4902 25 pathoganesis pathoganesis NNP cord-015021-pol2qm74 4902 26 . . . cord-015021-pol2qm74 4903 1 In in IN cord-015021-pol2qm74 4903 2 order order NN cord-015021-pol2qm74 4903 3 to to TO cord-015021-pol2qm74 4903 4 gain gain VB cord-015021-pol2qm74 4903 5 further further JJ cord-015021-pol2qm74 4903 6 insight insight NN cord-015021-pol2qm74 4903 7 into into IN cord-015021-pol2qm74 4903 8 the the DT cord-015021-pol2qm74 4903 9 role role NN cord-015021-pol2qm74 4903 10 of of IN cord-015021-pol2qm74 4903 11 endotoxin endotoxin NN cord-015021-pol2qm74 4903 12 and and CC cord-015021-pol2qm74 4903 13 cytokines cytokine NNS cord-015021-pol2qm74 4903 14 in in IN cord-015021-pol2qm74 4903 15 the the DT cord-015021-pol2qm74 4903 16 pathogenesis pathogenesis NN cord-015021-pol2qm74 4903 17 of of IN cord-015021-pol2qm74 4903 18 the the DT cord-015021-pol2qm74 4903 19 adult adult NN cord-015021-pol2qm74 4903 20 respiratory respiratory JJ cord-015021-pol2qm74 4903 21 distress distress NN cord-015021-pol2qm74 4903 22 syndrome syndrome NN cord-015021-pol2qm74 4903 23 ( ( -LRB- cord-015021-pol2qm74 4903 24 ARDS ARDS NNP cord-015021-pol2qm74 4903 25 ) ) -RRB- cord-015021-pol2qm74 4903 26 , , , cord-015021-pol2qm74 4903 27 we -PRON- PRP cord-015021-pol2qm74 4903 28 enrolled enrol VBD cord-015021-pol2qm74 4903 29 23 23 CD cord-015021-pol2qm74 4903 30 patients patient NNS cord-015021-pol2qm74 4903 31 with with IN cord-015021-pol2qm74 4903 32 severe severe JJ cord-015021-pol2qm74 4903 33 lung lung NN cord-015021-pol2qm74 4903 34 injury injury NN cord-015021-pol2qm74 4903 35 after after IN cord-015021-pol2qm74 4903 36 sepsis sepsis NN cord-015021-pol2qm74 4903 37 ( ( -LRB- cord-015021-pol2qm74 4903 38 17 17 CD cord-015021-pol2qm74 4903 39 ) ) -RRB- cord-015021-pol2qm74 4903 40 or or CC cord-015021-pol2qm74 4903 41 polytrauma polytrauma NNP cord-015021-pol2qm74 4903 42 ( ( -LRB- cord-015021-pol2qm74 4903 43 6 6 CD cord-015021-pol2qm74 4903 44 ) ) -RRB- cord-015021-pol2qm74 4903 45 and and CC cord-015021-pol2qm74 4903 46 obtained obtain VBD cord-015021-pol2qm74 4903 47 multiple multiple JJ cord-015021-pol2qm74 4903 48 blood blood NN cord-015021-pol2qm74 4903 49 samples sample NNS cord-015021-pol2qm74 4903 50 ( ( -LRB- cord-015021-pol2qm74 4903 51 14 14 CD cord-015021-pol2qm74 4903 52 days day NNS cord-015021-pol2qm74 4903 53 ) ) -RRB- cord-015021-pol2qm74 4903 54 for for IN cord-015021-pol2qm74 4903 55 endotoxin endotoxin NN cord-015021-pol2qm74 4903 56 , , , cord-015021-pol2qm74 4903 57 tumor tumor NN cord-015021-pol2qm74 4903 58 necrosis necrosis NN cord-015021-pol2qm74 4903 59 factor factor NN cord-015021-pol2qm74 4903 60 e e NNP cord-015021-pol2qm74 4903 61 ( ( -LRB- cord-015021-pol2qm74 4903 62 TNFa TNFa NNP cord-015021-pol2qm74 4903 63 ) ) -RRB- cord-015021-pol2qm74 4903 64 , , , cord-015021-pol2qm74 4903 65 interleukin interleukin NN cord-015021-pol2qm74 4903 66 18 18 CD cord-015021-pol2qm74 4903 67 ( ( -LRB- cord-015021-pol2qm74 4903 68 IL-18 IL-18 NNP cord-015021-pol2qm74 4903 69 ) ) -RRB- cord-015021-pol2qm74 4903 70 and and CC cord-015021-pol2qm74 4903 71 interleukin interleukin NN cord-015021-pol2qm74 4903 72 6 6 CD cord-015021-pol2qm74 4903 73 ( ( -LRB- cord-015021-pol2qm74 4903 74 IL-6 IL-6 NNP cord-015021-pol2qm74 4903 75 ) ) -RRB- cord-015021-pol2qm74 4903 76 determination determination NN cord-015021-pol2qm74 4903 77 . . . cord-015021-pol2qm74 4904 1 To to TO cord-015021-pol2qm74 4904 2 evaluate evaluate VB cord-015021-pol2qm74 4904 3 the the DT cord-015021-pol2qm74 4904 4 cytokine cytokine NN cord-015021-pol2qm74 4904 5 releasing release VBG cord-015021-pol2qm74 4904 6 capacity capacity NN cord-015021-pol2qm74 4904 7 of of IN cord-015021-pol2qm74 4904 8 the the DT cord-015021-pol2qm74 4904 9 blood blood NN cord-015021-pol2qm74 4904 10 , , , cord-015021-pol2qm74 4904 11 plasma plasma NN cord-015021-pol2qm74 4904 12 concentrations concentration NNS cord-015021-pol2qm74 4904 13 of of IN cord-015021-pol2qm74 4904 14 TNFe TNFe NNS cord-015021-pol2qm74 4904 15 , , , cord-015021-pol2qm74 4904 16 IL IL NNP cord-015021-pol2qm74 4904 17 - - HYPH cord-015021-pol2qm74 4904 18 l8 l8 NNP cord-015021-pol2qm74 4904 19 and and CC cord-015021-pol2qm74 4904 20 IL-6 IL-6 NNP cord-015021-pol2qm74 4904 21 were be VBD cord-015021-pol2qm74 4904 22 also also RB cord-015021-pol2qm74 4904 23 determined determine VBN cord-015021-pol2qm74 4904 24 after after IN cord-015021-pol2qm74 4904 25 the the DT cord-015021-pol2qm74 4904 26 " " `` cord-015021-pol2qm74 4904 27 in in FW cord-015021-pol2qm74 4904 28 vitro vitro FW cord-015021-pol2qm74 4904 29 " " '' cord-015021-pol2qm74 4904 30 stimulation stimulation NN cord-015021-pol2qm74 4904 31 of of IN cord-015021-pol2qm74 4904 32 the the DT cord-015021-pol2qm74 4904 33 whole whole JJ cord-015021-pol2qm74 4904 34 blood blood NN cord-015021-pol2qm74 4904 35 samples sample NNS cord-015021-pol2qm74 4904 36 with with IN cord-015021-pol2qm74 4904 37 lipopolysaccharide lipopolysaccharide NN cord-015021-pol2qm74 4904 38 ( ( -LRB- cord-015021-pol2qm74 4904 39 LPS LPS NNP cord-015021-pol2qm74 4904 40 , , , cord-015021-pol2qm74 4904 41 0.1 0.1 CD cord-015021-pol2qm74 4904 42 ng ng NN cord-015021-pol2qm74 4904 43 / / SYM cord-015021-pol2qm74 4904 44 ml ml NN cord-015021-pol2qm74 4904 45 ) ) -RRB- cord-015021-pol2qm74 4904 46 for for IN cord-015021-pol2qm74 4904 47 2 2 CD cord-015021-pol2qm74 4904 48 hours hour NNS cord-015021-pol2qm74 4904 49 at at IN cord-015021-pol2qm74 4904 50 370 370 CD cord-015021-pol2qm74 4904 51 C c NN cord-015021-pol2qm74 4904 52 ( ( -LRB- cord-015021-pol2qm74 4904 53 stimulated stimulate VBN cord-015021-pol2qm74 4904 54 values value NNS cord-015021-pol2qm74 4904 55 ) ) -RRB- cord-015021-pol2qm74 4904 56 . . . cord-015021-pol2qm74 4905 1 The the DT cord-015021-pol2qm74 4905 2 difference difference NN cord-015021-pol2qm74 4905 3 among among IN cord-015021-pol2qm74 4905 4 stimulated stimulate VBN cord-015021-pol2qm74 4905 5 cytokines cytokine NNS cord-015021-pol2qm74 4905 6 levels level NNS cord-015021-pol2qm74 4905 7 and and CC cord-015021-pol2qm74 4905 8 the the DT cord-015021-pol2qm74 4905 9 basal basal NN cord-015021-pol2qm74 4905 10 plasma plasma NN cord-015021-pol2qm74 4905 11 concentrations concentration NNS cord-015021-pol2qm74 4905 12 were be VBD cord-015021-pol2qm74 4905 13 defined define VBN cord-015021-pol2qm74 4905 14 as as IN cord-015021-pol2qm74 4905 15 " " `` cord-015021-pol2qm74 4905 16 delta delta NN cord-015021-pol2qm74 4905 17 values value NNS cord-015021-pol2qm74 4905 18 " " '' cord-015021-pol2qm74 4905 19 , , , cord-015021-pol2qm74 4905 20 an an DT cord-015021-pol2qm74 4905 21 expression expression NN cord-015021-pol2qm74 4905 22 of of IN cord-015021-pol2qm74 4905 23 the the DT cord-015021-pol2qm74 4905 24 cytokine cytokine NN cord-015021-pol2qm74 4905 25 releasing release VBG cord-015021-pol2qm74 4905 26 capacity capacity NN cord-015021-pol2qm74 4905 27 of of IN cord-015021-pol2qm74 4905 28 the the DT cord-015021-pol2qm74 4905 29 blood blood NN cord-015021-pol2qm74 4905 30 . . . cord-015021-pol2qm74 4906 1 The the DT cord-015021-pol2qm74 4906 2 pao2 pao2 NN cord-015021-pol2qm74 4906 3 / / SYM cord-015021-pol2qm74 4906 4 fiao2 fiao2 NN cord-015021-pol2qm74 4906 5 quotient quotient NN cord-015021-pol2qm74 4906 6 was be VBD cord-015021-pol2qm74 4906 7 used use VBN cord-015021-pol2qm74 4906 8 as as IN cord-015021-pol2qm74 4906 9 an an DT cord-015021-pol2qm74 4906 10 index index NN cord-015021-pol2qm74 4906 11 of of IN cord-015021-pol2qm74 4906 12 the the DT cord-015021-pol2qm74 4906 13 severity severity NN cord-015021-pol2qm74 4906 14 of of IN cord-015021-pol2qm74 4906 15 lung lung NN cord-015021-pol2qm74 4906 16 injury injury NN cord-015021-pol2qm74 4906 17 ( ( -LRB- cord-015021-pol2qm74 4906 18 SLI SLI NNP cord-015021-pol2qm74 4906 19 ) ) -RRB- cord-015021-pol2qm74 4906 20 . . . cord-015021-pol2qm74 4907 1 The the DT cord-015021-pol2qm74 4907 2 endotoxin endotoxin NN cord-015021-pol2qm74 4907 3 plasma plasma NN cord-015021-pol2qm74 4907 4 level level NN cord-015021-pol2qm74 4907 5 was be VBD cord-015021-pol2qm74 4907 6 significantly significantly RB cord-015021-pol2qm74 4907 7 higher high JJR cord-015021-pol2qm74 4907 8 in in IN cord-015021-pol2qm74 4907 9 patients patient NNS cord-015021-pol2qm74 4907 10 with with IN cord-015021-pol2qm74 4907 11 SLI SLI NNP cord-015021-pol2qm74 4907 12 < < XX cord-015021-pol2qm74 4907 13 200 200 CD cord-015021-pol2qm74 4907 14 ( ( -LRB- cord-015021-pol2qm74 4907 15 0.288 0.288 CD cord-015021-pol2qm74 4908 1 ± ± NNP cord-015021-pol2qm74 4908 2 0.038 0.038 CD cord-015021-pol2qm74 4909 1 EU EU NNP cord-015021-pol2qm74 4909 2 / / SYM cord-015021-pol2qm74 4909 3 ml ml NN cord-015021-pol2qm74 4909 4 , , , cord-015021-pol2qm74 4910 1 mean mean JJ cord-015021-pol2qm74 4910 2 values value NNS cord-015021-pol2qm74 4910 3 ± ± NNP cord-015021-pol2qm74 4910 4 SEM SEM NNP cord-015021-pol2qm74 4910 5 ) ) -RRB- cord-015021-pol2qm74 4910 6 versus versus IN cord-015021-pol2qm74 4910 7 the the DT cord-015021-pol2qm74 4910 8 patients patient NNS cord-015021-pol2qm74 4910 9 with with IN cord-015021-pol2qm74 4910 10 a a DT cord-015021-pol2qm74 4910 11 SLI sli NN cord-015021-pol2qm74 4911 1 > > XX cord-015021-pol2qm74 4911 2 200 200 CD cord-015021-pol2qm74 4911 3 ( ( -LRB- cord-015021-pol2qm74 4911 4 0.175 0.175 CD cord-015021-pol2qm74 4911 5 ± ± CD cord-015021-pol2qm74 4911 6 0.023 0.023 CD cord-015021-pol2qm74 4911 7 EU EU NNP cord-015021-pol2qm74 4911 8 / / SYM cord-015021-pol2qm74 4911 9 ml ml NN cord-015021-pol2qm74 4911 10 , , , cord-015021-pol2qm74 4911 11 p p NN cord-015021-pol2qm74 4911 12 < < XX cord-015021-pol2qm74 4911 13 O.01 o.01 CD cord-015021-pol2qm74 4911 14 ) ) -RRB- cord-015021-pol2qm74 4911 15 . . . cord-015021-pol2qm74 4912 1 The the DT cord-015021-pol2qm74 4912 2 basal basal NN cord-015021-pol2qm74 4912 3 plasma plasma NN cord-015021-pol2qm74 4912 4 concentration concentration NN cord-015021-pol2qm74 4912 5 of of IN cord-015021-pol2qm74 4912 6 ll-6 ll-6 NNP cord-015021-pol2qm74 4912 7 also also RB cord-015021-pol2qm74 4912 8 correlates correlate VBZ cord-015021-pol2qm74 4912 9 with with IN cord-015021-pol2qm74 4912 10 the the DT cord-015021-pol2qm74 4912 11 SLI SLI NNP cord-015021-pol2qm74 4912 12 index index NN cord-015021-pol2qm74 4912 13 ( ( -LRB- cord-015021-pol2qm74 4912 14 p p NN cord-015021-pol2qm74 4912 15 < < XX cord-015021-pol2qm74 4912 16 O.O01 o.o01 NN cord-015021-pol2qm74 4912 17 ) ) -RRB- cord-015021-pol2qm74 4912 18 . . . cord-015021-pol2qm74 4913 1 The the DT cord-015021-pol2qm74 4913 2 delta delta NN cord-015021-pol2qm74 4913 3 TNFe TNFe NNS cord-015021-pol2qm74 4913 4 and and CC cord-015021-pol2qm74 4913 5 delta delta NNP cord-015021-pol2qm74 4913 6 IL-6 IL-6 NNP cord-015021-pol2qm74 4913 7 values value NNS cord-015021-pol2qm74 4913 8 were be VBD cord-015021-pol2qm74 4913 9 s~ s~ CD cord-015021-pol2qm74 4914 1 gnificantly gnificantly RB cord-015021-pol2qm74 4914 2 decreased decrease VBD cord-015021-pol2qm74 4914 3 in in IN cord-015021-pol2qm74 4914 4 patients patient NNS cord-015021-pol2qm74 4914 5 with with IN cord-015021-pol2qm74 4914 6 a a DT cord-015021-pol2qm74 4914 7 severe severe JJ cord-015021-pol2qm74 4914 8 lung lung NN cord-015021-pol2qm74 4914 9 injury injury NN cord-015021-pol2qm74 4914 10 . . . cord-015021-pol2qm74 4915 1 Compared compare VBN cord-015021-pol2qm74 4915 2 with with IN cord-015021-pol2qm74 4915 3 the the DT cord-015021-pol2qm74 4915 4 survivors survivor NNS cord-015021-pol2qm74 4915 5 ( ( -LRB- cord-015021-pol2qm74 4915 6 n:11 n:11 CD cord-015021-pol2qm74 4915 7 ) ) -RRB- cord-015021-pol2qm74 4915 8 , , , cord-015021-pol2qm74 4915 9 the the DT cord-015021-pol2qm74 4915 10 deceased deceased JJ cord-015021-pol2qm74 4915 11 patients patient NNS cord-015021-pol2qm74 4915 12 ( ( -LRB- cord-015021-pol2qm74 4915 13 n=12 n=12 NNP cord-015021-pol2qm74 4915 14 ) ) -RRB- cord-015021-pol2qm74 4915 15 showed show VBD cord-015021-pol2qm74 4915 16 higher high JJR cord-015021-pol2qm74 4915 17 endotoxin endotoxin NN cord-015021-pol2qm74 4915 18 level level NN cord-015021-pol2qm74 4915 19 , , , cord-015021-pol2qm74 4915 20 a a DT cord-015021-pol2qm74 4915 21 reduced reduce VBN cord-015021-pol2qm74 4915 22 TNFa TNFa NNS cord-015021-pol2qm74 4915 23 and and CC cord-015021-pol2qm74 4915 24 IL-6 IL-6 NNP cord-015021-pol2qm74 4915 25 releasing release VBG cord-015021-pol2qm74 4915 26 capacity capacity NN cord-015021-pol2qm74 4915 27 of of IN cord-015021-pol2qm74 4915 28 the the DT cord-015021-pol2qm74 4915 29 blood blood NN cord-015021-pol2qm74 4915 30 and and CC cord-015021-pol2qm74 4915 31 higher high JJR cord-015021-pol2qm74 4915 32 basal basal NN cord-015021-pol2qm74 4915 33 IL-6 IL-6 NNP cord-015021-pol2qm74 4915 34 levels level NNS cord-015021-pol2qm74 4915 35 . . . cord-015021-pol2qm74 4916 1 We -PRON- PRP cord-015021-pol2qm74 4916 2 can can MD cord-015021-pol2qm74 4916 3 conclude conclude VB cord-015021-pol2qm74 4916 4 that that IN cord-015021-pol2qm74 4916 5 endotoxemia endotoxemia NN cord-015021-pol2qm74 4916 6 , , , cord-015021-pol2qm74 4916 7 high high JJ cord-015021-pol2qm74 4916 8 IL-6 IL-6 NNP cord-015021-pol2qm74 4916 9 plasma plasma NN cord-015021-pol2qm74 4916 10 level level NN cord-015021-pol2qm74 4916 11 and and CC cord-015021-pol2qm74 4916 12 a a DT cord-015021-pol2qm74 4916 13 decreased decrease VBN cord-015021-pol2qm74 4916 14 capacity capacity NN cord-015021-pol2qm74 4916 15 of of IN cord-015021-pol2qm74 4916 16 the the DT cord-015021-pol2qm74 4916 17 blood blood NN cord-015021-pol2qm74 4916 18 to to TO cord-015021-pol2qm74 4916 19 release release VB cord-015021-pol2qm74 4916 20 TNFa TNFa NNS cord-015021-pol2qm74 4916 21 an an DT cord-015021-pol2qm74 4916 22 IL-6 IL-6 NNP cord-015021-pol2qm74 4916 23 under under IN cord-015021-pol2qm74 4916 24 endotoxin endotoxin NN cord-015021-pol2qm74 4916 25 stimulation stimulation NN cord-015021-pol2qm74 4916 26 associates associate NNS cord-015021-pol2qm74 4916 27 with with IN cord-015021-pol2qm74 4916 28 the the DT cord-015021-pol2qm74 4916 29 severity severity NN cord-015021-pol2qm74 4916 30 of of IN cord-015021-pol2qm74 4916 31 lung lung NN cord-015021-pol2qm74 4916 32 injury injury NN cord-015021-pol2qm74 4916 33 . . . cord-015021-pol2qm74 4917 1 [ [ -LRB- cord-015021-pol2qm74 4917 2 Objectives Objectives NNP cord-015021-pol2qm74 4917 3 ] ] -RRB- cord-015021-pol2qm74 4917 4 Experimental experimental JJ cord-015021-pol2qm74 4917 5 and and CC cord-015021-pol2qm74 4917 6 clinical clinical JJ cord-015021-pol2qm74 4917 7 findings finding NNS cord-015021-pol2qm74 4917 8 implicate implicate VBP cord-015021-pol2qm74 4917 9 the the DT cord-015021-pol2qm74 4917 10 involvement involvement NN cord-015021-pol2qm74 4917 11 of of IN cord-015021-pol2qm74 4917 12 inflammatory inflammatory JJ cord-015021-pol2qm74 4917 13 cytokines cytokine NNS cord-015021-pol2qm74 4917 14 in in IN cord-015021-pol2qm74 4917 15 the the DT cord-015021-pol2qm74 4917 16 pathogenesis pathogenesis NN cord-015021-pol2qm74 4917 17 of of IN cord-015021-pol2qm74 4917 18 the the DT cord-015021-pol2qm74 4917 19 decreased decreased JJ cord-015021-pol2qm74 4917 20 oxygenation oxygenation NN cord-015021-pol2qm74 4917 21 in in IN cord-015021-pol2qm74 4917 22 the the DT cord-015021-pol2qm74 4917 23 lung lung NN cord-015021-pol2qm74 4917 24 after after IN cord-015021-pol2qm74 4917 25 major major JJ cord-015021-pol2qm74 4917 26 surgery surgery NN cord-015021-pol2qm74 4917 27 , , , cord-015021-pol2qm74 4917 28 though though IN cord-015021-pol2qm74 4917 29 the the DT cord-015021-pol2qm74 4917 30 mechanism mechanism NN cord-015021-pol2qm74 4917 31 remains remain VBZ cord-015021-pol2qm74 4917 32 unclear unclear JJ cord-015021-pol2qm74 4917 33 . . . cord-015021-pol2qm74 4918 1 In in IN cord-015021-pol2qm74 4918 2 the the DT cord-015021-pol2qm74 4918 3 present present JJ cord-015021-pol2qm74 4918 4 study study NN cord-015021-pol2qm74 4918 5 , , , cord-015021-pol2qm74 4918 6 we -PRON- PRP cord-015021-pol2qm74 4918 7 elucidated elucidate VBD cord-015021-pol2qm74 4918 8 the the DT cord-015021-pol2qm74 4918 9 involvement involvement NN cord-015021-pol2qm74 4918 10 of of IN cord-015021-pol2qm74 4918 11 IL-8 IL-8 NNP cord-015021-pol2qm74 4918 12 in in IN cord-015021-pol2qm74 4918 13 the the DT cord-015021-pol2qm74 4918 14 pathogenesis pathogenesis NN cord-015021-pol2qm74 4918 15 of of IN cord-015021-pol2qm74 4918 16 lung lung NN cord-015021-pol2qm74 4918 17 injury injury NN cord-015021-pol2qm74 4918 18 defined define VBN cord-015021-pol2qm74 4918 19 by by IN cord-015021-pol2qm74 4918 20 deterioration deterioration NN cord-015021-pol2qm74 4918 21 of of IN cord-015021-pol2qm74 4918 22 pulmonary pulmonary JJ cord-015021-pol2qm74 4918 23 oxygenation oxygenation NN cord-015021-pol2qm74 4918 24 after after IN cord-015021-pol2qm74 4918 25 esophagectomy esophagectomy NN cord-015021-pol2qm74 4918 26 . . . cord-015021-pol2qm74 4919 1 [ [ -LRB- cord-015021-pol2qm74 4919 2 Materials material NNS cord-015021-pol2qm74 4919 3 and and CC cord-015021-pol2qm74 4919 4 Methods Methods NNPS cord-015021-pol2qm74 4919 5 ] ] -RRB- cord-015021-pol2qm74 4919 6 Seventeen seventeen CD cord-015021-pol2qm74 4919 7 patients patient NNS cord-015021-pol2qm74 4919 8 underwent undergo VBD cord-015021-pol2qm74 4919 9 subtotal subtotal JJ cord-015021-pol2qm74 4919 10 esophagectomy esophagectomy NN cord-015021-pol2qm74 4919 11 through through IN cord-015021-pol2qm74 4919 12 a a DT cord-015021-pol2qm74 4919 13 right right JJ cord-015021-pol2qm74 4919 14 thoracotomy thoracotomy NN cord-015021-pol2qm74 4919 15 . . . cord-015021-pol2qm74 4920 1 In in IN cord-015021-pol2qm74 4920 2 all all DT cord-015021-pol2qm74 4920 3 patients patient NNS cord-015021-pol2qm74 4920 4 , , , cord-015021-pol2qm74 4920 5 tbe tbe NN cord-015021-pol2qm74 4920 6 alveolar alveolar NN cord-015021-pol2qm74 4920 7 - - HYPH cord-015021-pol2qm74 4920 8 arterial arterial JJ cord-015021-pol2qm74 4920 9 oxygen oxygen NN cord-015021-pol2qm74 4920 10 tension tension NN cord-015021-pol2qm74 4920 11 difference difference NN cord-015021-pol2qm74 4920 12 ( ( -LRB- cord-015021-pol2qm74 4920 13 AaDO2 AaDO2 NNP cord-015021-pol2qm74 4920 14 ) ) -RRB- cord-015021-pol2qm74 4920 15 was be VBD cord-015021-pol2qm74 4920 16 measured measure VBN cord-015021-pol2qm74 4920 17 everyday everyday RB cord-015021-pol2qm74 4920 18 and and CC cord-015021-pol2qm74 4920 19 bronchoalveolar bronchoalveolar NNP cord-015021-pol2qm74 4920 20 lavage lavage NN cord-015021-pol2qm74 4920 21 fluid fluid NN cord-015021-pol2qm74 4920 22 ( ( -LRB- cord-015021-pol2qm74 4920 23 BALF BALF NNP cord-015021-pol2qm74 4920 24 ) ) -RRB- cord-015021-pol2qm74 4920 25 samples sample NNS cord-015021-pol2qm74 4920 26 were be VBD cord-015021-pol2qm74 4920 27 obtained obtain VBN cord-015021-pol2qm74 4920 28 from from IN cord-015021-pol2qm74 4920 29 a a DT cord-015021-pol2qm74 4920 30 single single JJ cord-015021-pol2qm74 4920 31 segment segment NN cord-015021-pol2qm74 4920 32 ( ( -LRB- cord-015021-pol2qm74 4920 33 $ $ $ cord-015021-pol2qm74 4920 34 4 4 CD cord-015021-pol2qm74 4920 35 or or CC cord-015021-pol2qm74 4920 36 $ $ $ cord-015021-pol2qm74 4920 37 5 5 CD cord-015021-pol2qm74 4920 38 ) ) -RRB- cord-015021-pol2qm74 4920 39 of of IN cord-015021-pol2qm74 4920 40 the the DT cord-015021-pol2qm74 4920 41 right right NN cord-015021-pol2qm74 4920 42 and and CC cord-015021-pol2qm74 4920 43 left leave VBD cord-015021-pol2qm74 4920 44 lung lung NN cord-015021-pol2qm74 4920 45 through through IN cord-015021-pol2qm74 4920 46 a a DT cord-015021-pol2qm74 4920 47 bronchoscope bronchoscope NN cord-015021-pol2qm74 4920 48 on on IN cord-015021-pol2qm74 4920 49 days day NNS cord-015021-pol2qm74 4920 50 l l NNP cord-015021-pol2qm74 4920 51 , , , cord-015021-pol2qm74 4920 52 3 3 CD cord-015021-pol2qm74 4920 53 , , , cord-015021-pol2qm74 4920 54 and and CC cord-015021-pol2qm74 4920 55 5 5 CD cord-015021-pol2qm74 4920 56 days day NNS cord-015021-pol2qm74 4920 57 after after IN cord-015021-pol2qm74 4920 58 surgery surgery NN cord-015021-pol2qm74 4920 59 . . . cord-015021-pol2qm74 4921 1 They -PRON- PRP cord-015021-pol2qm74 4921 2 were be VBD cord-015021-pol2qm74 4921 3 then then RB cord-015021-pol2qm74 4921 4 examined examine VBN cord-015021-pol2qm74 4921 5 for for IN cord-015021-pol2qm74 4921 6 cell cell NN cord-015021-pol2qm74 4921 7 analysis analysis NN cord-015021-pol2qm74 4921 8 , , , cord-015021-pol2qm74 4921 9 measurement measurement NN cord-015021-pol2qm74 4921 10 of of IN cord-015021-pol2qm74 4921 11 cytokines cytokine NNS cord-015021-pol2qm74 4921 12 by by IN cord-015021-pol2qm74 4921 13 ELISA ELISA NNP cord-015021-pol2qm74 4921 14 , , , cord-015021-pol2qm74 4921 15 and and CC cord-015021-pol2qm74 4921 16 measurement measurement NN cord-015021-pol2qm74 4921 17 of of IN cord-015021-pol2qm74 4921 18 neutrnphil neutrnphil NNP cord-015021-pol2qm74 4921 19 elastase elastase NN cord-015021-pol2qm74 4921 20 ( ( -LRB- cord-015021-pol2qm74 4921 21 NE NE NNP cord-015021-pol2qm74 4921 22 ) ) -RRB- cord-015021-pol2qm74 4921 23 by by IN cord-015021-pol2qm74 4921 24 ELISA ELISA NNP cord-015021-pol2qm74 4921 25 . . . cord-015021-pol2qm74 4922 1 [ [ -LRB- cord-015021-pol2qm74 4922 2 Results result NNS cord-015021-pol2qm74 4922 3 ] ] -RRB- cord-015021-pol2qm74 4922 4 AaDO2 AaDO2 NNP cord-015021-pol2qm74 4922 5 unexceptionally unexceptionally RB cord-015021-pol2qm74 4922 6 deteriorated deteriorate VBD cord-015021-pol2qm74 4922 7 postoperatively postoperatively RB cord-015021-pol2qm74 4922 8 and and CC cord-015021-pol2qm74 4922 9 the the DT cord-015021-pol2qm74 4922 10 mean mean JJ cord-015021-pol2qm74 4922 11 AaDO2 AaDO2 NNP cord-015021-pol2qm74 4922 12 in in IN cord-015021-pol2qm74 4922 13 17 17 CD cord-015021-pol2qm74 4922 14 patients patient NNS cord-015021-pol2qm74 4922 15 reached reach VBD cord-015021-pol2qm74 4922 16 the the DT cord-015021-pol2qm74 4922 17 maximum maximum NN cord-015021-pol2qm74 4922 18 ( ( -LRB- cord-015021-pol2qm74 4922 19 mean mean VB cord-015021-pol2qm74 4922 20 ± ± NNP cord-015021-pol2qm74 4922 21 SEM SEM NNP cord-015021-pol2qm74 4922 22 ; ; : cord-015021-pol2qm74 4922 23 372 372 CD cord-015021-pol2qm74 4922 24 _ _ NN cord-015021-pol2qm74 4922 25 + + SYM cord-015021-pol2qm74 4922 26 23 23 CD cord-015021-pol2qm74 4922 27 mmHg mmHg NNPS cord-015021-pol2qm74 4922 28 ) ) -RRB- cord-015021-pol2qm74 4922 29 on on IN cord-015021-pol2qm74 4922 30 the the DT cord-015021-pol2qm74 4922 31 3rd 3rd JJ cord-015021-pol2qm74 4922 32 postoperative postoperative JJ cord-015021-pol2qm74 4922 33 day day NN cord-015021-pol2qm74 4922 34 . . . cord-015021-pol2qm74 4923 1 The the DT cord-015021-pol2qm74 4923 2 mean mean JJ cord-015021-pol2qm74 4923 3 concentrations concentration NNS cord-015021-pol2qm74 4923 4 of of IN cord-015021-pol2qm74 4923 5 IL-8 IL-8 NNP cord-015021-pol2qm74 4923 6 , , , cord-015021-pol2qm74 4923 7 NE NE NNP cord-015021-pol2qm74 4923 8 and and CC cord-015021-pol2qm74 4923 9 neutrophil neutrophil NN cord-015021-pol2qm74 4923 10 count count NN cord-015021-pol2qm74 4923 11 in in IN cord-015021-pol2qm74 4923 12 BALF BALF NNP cord-015021-pol2qm74 4923 13 also also RB cord-015021-pol2qm74 4923 14 increased increase VBD cord-015021-pol2qm74 4923 15 postoperatively postoperatively RB cord-015021-pol2qm74 4923 16 and and CC cord-015021-pol2qm74 4923 17 reached reach VBD cord-015021-pol2qm74 4923 18 their -PRON- PRP$ cord-015021-pol2qm74 4923 19 maximum maximum JJ cord-015021-pol2qm74 4923 20 level level NN cord-015021-pol2qm74 4923 21 ( ( -LRB- cord-015021-pol2qm74 4923 22 2137 2137 CD cord-015021-pol2qm74 4923 23 + + SYM cord-015021-pol2qm74 4923 24 618 618 CD cord-015021-pol2qm74 4923 25 pg pg NN cord-015021-pol2qm74 4923 26 / / SYM cord-015021-pol2qm74 4923 27 ml ml NNS cord-015021-pol2qm74 4923 28 , , , cord-015021-pol2qm74 4923 29 1603 1603 CD cord-015021-pol2qm74 4923 30 -+ -+ SYM cord-015021-pol2qm74 4923 31 493 493 CD cord-015021-pol2qm74 4923 32 gg gg NNP cord-015021-pol2qm74 4923 33 / / SYM cord-015021-pol2qm74 4923 34 l l NN cord-015021-pol2qm74 4923 35 , , , cord-015021-pol2qm74 4923 36 and and CC cord-015021-pol2qm74 4923 37 1561 1561 CD cord-015021-pol2qm74 4923 38 ± ± CD cord-015021-pol2qm74 4923 39 477 477 CD cord-015021-pol2qm74 4923 40 x x SYM cord-015021-pol2qm74 4923 41 103 103 CD cord-015021-pol2qm74 4923 42 cells cell NNS cord-015021-pol2qm74 4923 43 / / SYM cord-015021-pol2qm74 4923 44 ml ml NNS cord-015021-pol2qm74 4923 45 , , , cord-015021-pol2qm74 4923 46 respectively respectively RB cord-015021-pol2qm74 4923 47 ) ) -RRB- cord-015021-pol2qm74 4923 48 on on IN cord-015021-pol2qm74 4923 49 the the DT cord-015021-pol2qm74 4923 50 3rd 3rd JJ cord-015021-pol2qm74 4923 51 postoperative postoperative JJ cord-015021-pol2qm74 4923 52 day day NN cord-015021-pol2qm74 4923 53 . . . cord-015021-pol2qm74 4924 1 These these DT cord-015021-pol2qm74 4924 2 increases increase NNS cord-015021-pol2qm74 4924 3 in in IN cord-015021-pol2qm74 4924 4 BALF BALF NNP cord-015021-pol2qm74 4924 5 were be VBD cord-015021-pol2qm74 4924 6 recognized recognize VBN cord-015021-pol2qm74 4924 7 in in IN cord-015021-pol2qm74 4924 8 both both CC cord-015021-pol2qm74 4924 9 the the DT cord-015021-pol2qm74 4924 10 right right NN cord-015021-pol2qm74 4924 11 and and CC cord-015021-pol2qm74 4924 12 left left JJ cord-015021-pol2qm74 4924 13 lung lung NN cord-015021-pol2qm74 4924 14 . . . cord-015021-pol2qm74 4925 1 A a DT cord-015021-pol2qm74 4925 2 highly highly RB cord-015021-pol2qm74 4925 3 significant significant JJ cord-015021-pol2qm74 4925 4 correlation correlation NN cord-015021-pol2qm74 4925 5 was be VBD cord-015021-pol2qm74 4925 6 observed observe VBN cord-015021-pol2qm74 4925 7 between between IN cord-015021-pol2qm74 4925 8 IL-8 IL-8 NNP cord-015021-pol2qm74 4925 9 and and CC cord-015021-pol2qm74 4925 10 NE NE NNP cord-015021-pol2qm74 4925 11 levels level NNS cord-015021-pol2qm74 4925 12 in in IN cord-015021-pol2qm74 4925 13 BALF BALF NNP cord-015021-pol2qm74 4925 14 ( ( -LRB- cord-015021-pol2qm74 4925 15 r=0.82 r=0.82 NNP cord-015021-pol2qm74 4925 16 , , , cord-015021-pol2qm74 4925 17 p=0.0001 p=0.0001 NNP cord-015021-pol2qm74 4925 18 ) ) -RRB- cord-015021-pol2qm74 4925 19 . . . cord-015021-pol2qm74 4926 1 Also also RB cord-015021-pol2qm74 4926 2 , , , cord-015021-pol2qm74 4926 3 significant significant JJ cord-015021-pol2qm74 4926 4 correlations correlation NNS cord-015021-pol2qm74 4926 5 between between IN cord-015021-pol2qm74 4926 6 AaDO2 aado2 NN cord-015021-pol2qm74 4926 7 and and CC cord-015021-pol2qm74 4926 8 the the DT cord-015021-pol2qm74 4926 9 neutropbil neutropbil NN cord-015021-pol2qm74 4926 10 count count NN cord-015021-pol2qm74 4926 11 , , , cord-015021-pol2qm74 4926 12 and and CC cord-015021-pol2qm74 4926 13 the the DT cord-015021-pol2qm74 4926 14 concentration concentration NN cord-015021-pol2qm74 4926 15 of of IN cord-015021-pol2qm74 4926 16 NE NE NNP cord-015021-pol2qm74 4926 17 or or CC cord-015021-pol2qm74 4926 18 1L-8 1l-8 CD cord-015021-pol2qm74 4926 19 were be VBD cord-015021-pol2qm74 4926 20 observed observe VBN cord-015021-pol2qm74 4926 21 . . . cord-015021-pol2qm74 4927 1 In in IN cord-015021-pol2qm74 4927 2 contrast contrast NN cord-015021-pol2qm74 4927 3 to to IN cord-015021-pol2qm74 4927 4 IL-8 IL-8 NNP cord-015021-pol2qm74 4927 5 , , , cord-015021-pol2qm74 4927 6 neither neither CC cord-015021-pol2qm74 4927 7 IL-6 IL-6 NNP cord-015021-pol2qm74 4927 8 , , , cord-015021-pol2qm74 4927 9 IL-113 il-113 NN cord-015021-pol2qm74 4927 10 nor nor CC cord-015021-pol2qm74 4927 11 TNFa TNFa NNP cord-015021-pol2qm74 4927 12 was be VBD cord-015021-pol2qm74 4927 13 detected detect VBN cord-015021-pol2qm74 4927 14 in in IN cord-015021-pol2qm74 4927 15 BALF BALF NNP cord-015021-pol2qm74 4927 16 . . . cord-015021-pol2qm74 4928 1 [ [ -LRB- cord-015021-pol2qm74 4928 2 Conclusion conclusion NN cord-015021-pol2qm74 4928 3 ] ] -RRB- cord-015021-pol2qm74 4928 4 Major major JJ cord-015021-pol2qm74 4928 5 surgical surgical JJ cord-015021-pol2qm74 4928 6 trauma trauma NN cord-015021-pol2qm74 4928 7 such such JJ cord-015021-pol2qm74 4928 8 as as IN cord-015021-pol2qm74 4928 9 esophagectomy esophagectomy NNP cord-015021-pol2qm74 4928 10 may may MD cord-015021-pol2qm74 4928 11 induce induce VB cord-015021-pol2qm74 4928 12 recruitment recruitment NN cord-015021-pol2qm74 4928 13 of of IN cord-015021-pol2qm74 4928 14 neutrophils neutrophil NNS cord-015021-pol2qm74 4928 15 to to IN cord-015021-pol2qm74 4928 16 the the DT cord-015021-pol2qm74 4928 17 lung lung NN cord-015021-pol2qm74 4928 18 and and CC cord-015021-pol2qm74 4928 19 cause cause VB cord-015021-pol2qm74 4928 20 lung lung NN cord-015021-pol2qm74 4928 21 injury injury NN cord-015021-pol2qm74 4928 22 . . . cord-015021-pol2qm74 4929 1 IL-8 IL-8 NNP cord-015021-pol2qm74 4929 2 increased increase VBD cord-015021-pol2qm74 4929 3 in in IN cord-015021-pol2qm74 4929 4 the the DT cord-015021-pol2qm74 4929 5 lung lung NN cord-015021-pol2qm74 4929 6 is be VBZ cord-015021-pol2qm74 4929 7 an an DT cord-015021-pol2qm74 4929 8 important important JJ cord-015021-pol2qm74 4929 9 mediator mediator NN cord-015021-pol2qm74 4929 10 of of IN cord-015021-pol2qm74 4929 11 neutrophil neutrophil NN cord-015021-pol2qm74 4929 12 recruitment recruitment NN cord-015021-pol2qm74 4929 13 and and CC cord-015021-pol2qm74 4929 14 activation activation NN cord-015021-pol2qm74 4929 15 in in IN cord-015021-pol2qm74 4929 16 the the DT cord-015021-pol2qm74 4929 17 lung lung NN cord-015021-pol2qm74 4929 18 . . . cord-015021-pol2qm74 4930 1 Phorbol Phorbol NNP cord-015021-pol2qm74 4930 2 myristate myristate NN cord-015021-pol2qm74 4930 3 acetate acetate NN cord-015021-pol2qm74 4930 4 ( ( -LRB- cord-015021-pol2qm74 4930 5 PMA PMA NNP cord-015021-pol2qm74 4930 6 ) ) -RRB- cord-015021-pol2qm74 4930 7 is be VBZ cord-015021-pol2qm74 4930 8 commonly commonly RB cord-015021-pol2qm74 4930 9 used use VBN cord-015021-pol2qm74 4930 10 to to TO cord-015021-pol2qm74 4930 11 cause cause VB cord-015021-pol2qm74 4930 12 edema edema NN cord-015021-pol2qm74 4930 13 and and CC cord-015021-pol2qm74 4930 14 other other JJ cord-015021-pol2qm74 4930 15 tissue tissue NN cord-015021-pol2qm74 4930 16 damages damage NNS cord-015021-pol2qm74 4930 17 in in IN cord-015021-pol2qm74 4930 18 the the DT cord-015021-pol2qm74 4930 19 lung lung NN cord-015021-pol2qm74 4930 20 . . . cord-015021-pol2qm74 4931 1 Lung lung NN cord-015021-pol2qm74 4931 2 injuries injury NNS cord-015021-pol2qm74 4931 3 induced induce VBN cord-015021-pol2qm74 4931 4 by by IN cord-015021-pol2qm74 4931 5 the the DT cord-015021-pol2qm74 4931 6 administration administration NN cord-015021-pol2qm74 4931 7 of of IN cord-015021-pol2qm74 4931 8 PMA PMA NNP cord-015021-pol2qm74 4931 9 has have VBZ cord-015021-pol2qm74 4931 10 been be VBN cord-015021-pol2qm74 4931 11 shown show VBN cord-015021-pol2qm74 4931 12 to to TO cord-015021-pol2qm74 4931 13 be be VB cord-015021-pol2qm74 4931 14 mediated mediate VBN cord-015021-pol2qm74 4931 15 mainly mainly RB cord-015021-pol2qm74 4931 16 by by IN cord-015021-pol2qm74 4931 17 neutrophils neutrophil NNS cord-015021-pol2qm74 4931 18 . . . cord-015021-pol2qm74 4932 1 Neutrophils neutrophil NNS cord-015021-pol2qm74 4932 2 recruited recruit VBN cord-015021-pol2qm74 4932 3 to to IN cord-015021-pol2qm74 4932 4 the the DT cord-015021-pol2qm74 4932 5 lower low JJR cord-015021-pol2qm74 4932 6 respiratory respiratory JJ cord-015021-pol2qm74 4932 7 tract tract NN cord-015021-pol2qm74 4932 8 may may MD cord-015021-pol2qm74 4932 9 damage damage VB cord-015021-pol2qm74 4932 10 lung lung NN cord-015021-pol2qm74 4932 11 tissues tissue NNS cord-015021-pol2qm74 4932 12 by by IN cord-015021-pol2qm74 4932 13 releasing release VBG cord-015021-pol2qm74 4932 14 reactive reactive JJ cord-015021-pol2qm74 4932 15 oxygen oxygen NN cord-015021-pol2qm74 4932 16 species specie NNS cord-015021-pol2qm74 4932 17 , , , cord-015021-pol2qm74 4932 18 neutral neutral JJ cord-015021-pol2qm74 4932 19 proteases protease NNS cord-015021-pol2qm74 4932 20 and and CC cord-015021-pol2qm74 4932 21 lysosomal lysosomal JJ cord-015021-pol2qm74 4932 22 enzymes enzyme NNS cord-015021-pol2qm74 4932 23 . . . cord-015021-pol2qm74 4933 1 The the DT cord-015021-pol2qm74 4933 2 present present JJ cord-015021-pol2qm74 4933 3 study study NN cord-015021-pol2qm74 4933 4 was be VBD cord-015021-pol2qm74 4933 5 conducted conduct VBN cord-015021-pol2qm74 4933 6 to to TO cord-015021-pol2qm74 4933 7 investigate investigate VB cord-015021-pol2qm74 4933 8 whether whether IN cord-015021-pol2qm74 4933 9 c c NN cord-015021-pol2qm74 4933 10 ~ ~ NFP cord-015021-pol2qm74 4933 11 tocopherol tocopherol NN cord-015021-pol2qm74 4933 12 , , , cord-015021-pol2qm74 4933 13 entrapped entrap VBN cord-015021-pol2qm74 4933 14 in in IN cord-015021-pol2qm74 4933 15 dipalmitoylphosphatidylcholine dipalmitoylphosphatidylcholine NN cord-015021-pol2qm74 4933 16 liposomes liposome NNS cord-015021-pol2qm74 4933 17 and and CC cord-015021-pol2qm74 4933 18 delivered deliver VBD cord-015021-pol2qm74 4933 19 directly directly RB cord-015021-pol2qm74 4933 20 to to IN cord-015021-pol2qm74 4933 21 the the DT cord-015021-pol2qm74 4933 22 lung lung NN cord-015021-pol2qm74 4933 23 , , , cord-015021-pol2qm74 4933 24 could could MD cord-015021-pol2qm74 4933 25 counteract counteract VB cord-015021-pol2qm74 4933 26 some some DT cord-015021-pol2qm74 4933 27 of of IN cord-015021-pol2qm74 4933 28 the the DT cord-015021-pol2qm74 4933 29 PMA PMA NNP cord-015021-pol2qm74 4933 30 - - HYPH cord-015021-pol2qm74 4933 31 induced induce VBN cord-015021-pol2qm74 4933 32 lung lung NN cord-015021-pol2qm74 4933 33 injuries injury NNS cord-015021-pol2qm74 4933 34 . . . cord-015021-pol2qm74 4934 1 Plain plain JJ cord-015021-pol2qm74 4934 2 liposomes liposome NNS cord-015021-pol2qm74 4934 3 or or CC cord-015021-pol2qm74 4934 4 c c NN cord-015021-pol2qm74 4934 5 ~ ~ NFP cord-015021-pol2qm74 4934 6 tocopherol tocopherol NN cord-015021-pol2qm74 4934 7 - - HYPH cord-015021-pol2qm74 4934 8 containing contain VBG cord-015021-pol2qm74 4934 9 liposomes liposome NNS cord-015021-pol2qm74 4934 10 ( ( -LRB- cord-015021-pol2qm74 4934 11 8 8 CD cord-015021-pol2qm74 4934 12 mg mg NNP cord-015021-pol2qm74 4934 13 c~-tocopherol c~-tocopherol NNP cord-015021-pol2qm74 4934 14 / / SYM cord-015021-pol2qm74 4934 15 kgbody kgbody NNP cord-015021-pol2qm74 4934 16 wt wt NNP cord-015021-pol2qm74 4934 17 . . . cord-015021-pol2qm74 4934 18 ) ) -RRB- cord-015021-pol2qm74 4934 19 were be VBD cord-015021-pol2qm74 4934 20 instilled instill VBN cord-015021-pol2qm74 4934 21 into into IN cord-015021-pol2qm74 4934 22 the the DT cord-015021-pol2qm74 4934 23 lungs lung NNS cord-015021-pol2qm74 4934 24 of of IN cord-015021-pol2qm74 4934 25 rats rat NNS cord-015021-pol2qm74 4934 26 24 24 CD cord-015021-pol2qm74 4934 27 h h NN cord-015021-pol2qm74 4934 28 prior prior RB cord-015021-pol2qm74 4934 29 to to IN cord-015021-pol2qm74 4934 30 PMA PMA NNP cord-015021-pol2qm74 4934 31 exposure exposure NN cord-015021-pol2qm74 4934 32 ( ( -LRB- cord-015021-pol2qm74 4934 33 25 25 CD cord-015021-pol2qm74 4934 34 pg pg NN cord-015021-pol2qm74 4934 35 / / SYM cord-015021-pol2qm74 4934 36 kg kg NNP cord-015021-pol2qm74 4934 37 , , , cord-015021-pol2qm74 4934 38 intratracheally intratracheally RB cord-015021-pol2qm74 4934 39 ) ) -RRB- cord-015021-pol2qm74 4934 40 and and CC cord-015021-pol2qm74 4934 41 treated treat VBN cord-015021-pol2qm74 4934 42 rats rat NNS cord-015021-pol2qm74 4934 43 were be VBD cord-015021-pol2qm74 4934 44 killed kill VBN cord-015021-pol2qm74 4934 45 3 3 CD cord-015021-pol2qm74 4934 46 h h NN cord-015021-pol2qm74 4934 47 later later RB cord-015021-pol2qm74 4934 48 . . . cord-015021-pol2qm74 4935 1 Lungs lung NNS cord-015021-pol2qm74 4935 2 of of IN cord-015021-pol2qm74 4935 3 control control NN cord-015021-pol2qm74 4935 4 animals animal NNS cord-015021-pol2qm74 4935 5 exposed expose VBN cord-015021-pol2qm74 4935 6 to to IN cord-015021-pol2qm74 4935 7 PMA PMA NNP cord-015021-pol2qm74 4935 8 developed develop VBD cord-015021-pol2qm74 4935 9 increases increase NNS cord-015021-pol2qm74 4935 10 in in IN cord-015021-pol2qm74 4935 11 lung lung NN cord-015021-pol2qm74 4935 12 weight weight NN cord-015021-pol2qm74 4935 13 and and CC cord-015021-pol2qm74 4935 14 lipid lipid NN cord-015021-pol2qm74 4935 15 peroxidation peroxidation NN cord-015021-pol2qm74 4935 16 as as RB cord-015021-pol2qm74 4935 17 well well RB cord-015021-pol2qm74 4935 18 as as IN cord-015021-pol2qm74 4935 19 decreases decrease NNS cord-015021-pol2qm74 4935 20 in in IN cord-015021-pol2qm74 4935 21 lung lung NN cord-015021-pol2qm74 4935 22 angiotensin angiotensin NN cord-015021-pol2qm74 4935 23 converting convert VBG cord-015021-pol2qm74 4935 24 enzyme enzyme NN cord-015021-pol2qm74 4935 25 ( ( -LRB- cord-015021-pol2qm74 4935 26 ACE ace NN cord-015021-pol2qm74 4935 27 ) ) -RRB- cord-015021-pol2qm74 4935 28 and and CC cord-015021-pol2qm74 4935 29 alkaline alkaline JJ cord-015021-pol2qm74 4935 30 phosphatase phosphatase NN cord-015021-pol2qm74 4935 31 ( ( -LRB- cord-015021-pol2qm74 4935 32 AKP AKP NNP cord-015021-pol2qm74 4935 33 ) ) -RRB- cord-015021-pol2qm74 4935 34 activities activity NNS cord-015021-pol2qm74 4935 35 . . . cord-015021-pol2qm74 4936 1 PMA PMA NNP cord-015021-pol2qm74 4936 2 treatment treatment NN cord-015021-pol2qm74 4936 3 also also RB cord-015021-pol2qm74 4936 4 caused cause VBD cord-015021-pol2qm74 4936 5 an an DT cord-015021-pol2qm74 4936 6 increase increase NN cord-015021-pol2qm74 4936 7 in in IN cord-015021-pol2qm74 4936 8 myeloperoxidase myeloperoxidase NN cord-015021-pol2qm74 4936 9 ( ( -LRB- cord-015021-pol2qm74 4936 10 MPO MPO NNP cord-015021-pol2qm74 4936 11 ) ) -RRB- cord-015021-pol2qm74 4936 12 activity activity NN cord-015021-pol2qm74 4936 13 in in IN cord-015021-pol2qm74 4936 14 the the DT cord-015021-pol2qm74 4936 15 lung lung NN cord-015021-pol2qm74 4936 16 , , , cord-015021-pol2qm74 4936 17 suggestive suggestive JJ cord-015021-pol2qm74 4936 18 of of IN cord-015021-pol2qm74 4936 19 neutrophi neutrophi JJ cord-015021-pol2qm74 4936 20 ] ] -RRB- cord-015021-pol2qm74 4936 21 infiltration infiltration NN cord-015021-pol2qm74 4936 22 . . . cord-015021-pol2qm74 4937 1 Pretreatment pretreatment NN cord-015021-pol2qm74 4937 2 of of IN cord-015021-pol2qm74 4937 3 PMA PMA NNP cord-015021-pol2qm74 4937 4 - - HYPH cord-015021-pol2qm74 4937 5 treated treat VBN cord-015021-pol2qm74 4937 6 rats rat NNS cord-015021-pol2qm74 4937 7 with with IN cord-015021-pol2qm74 4937 8 plain plain JJ cord-015021-pol2qm74 4937 9 liposomes liposome NNS cord-015021-pol2qm74 4937 10 had have VBD cord-015021-pol2qm74 4937 11 no no DT cord-015021-pol2qm74 4937 12 effect effect NN cord-015021-pol2qm74 4937 13 on on IN cord-015021-pol2qm74 4937 14 PMA PMA NNP cord-015021-pol2qm74 4937 15 - - HYPH cord-015021-pol2qm74 4937 16 induced induce VBN cord-015021-pol2qm74 4937 17 injuries injury NNS cord-015021-pol2qm74 4937 18 . . . cord-015021-pol2qm74 4938 1 In in IN cord-015021-pol2qm74 4938 2 contrast contrast NN cord-015021-pol2qm74 4938 3 , , , cord-015021-pol2qm74 4938 4 pretreatment pretreatment NN cord-015021-pol2qm74 4938 5 of of IN cord-015021-pol2qm74 4938 6 rats rat NNS cord-015021-pol2qm74 4938 7 with with IN cord-015021-pol2qm74 4938 8 liposomal liposomal JJ cord-015021-pol2qm74 4938 9 c~-tocopherol c~-tocopherol NNP cord-015021-pol2qm74 4938 10 , , , cord-015021-pol2qm74 4938 11 24 24 CD cord-015021-pol2qm74 4938 12 h h NN cord-015021-pol2qm74 4938 13 prior prior RB cord-015021-pol2qm74 4938 14 to to IN cord-015021-pol2qm74 4938 15 PMA PMA NNP cord-015021-pol2qm74 4938 16 administration administration NN cord-015021-pol2qm74 4938 17 , , , cord-015021-pol2qm74 4938 18 resulted result VBD cord-015021-pol2qm74 4938 19 in in IN cord-015021-pol2qm74 4938 20 a a DT cord-015021-pol2qm74 4938 21 significant significant JJ cord-015021-pol2qm74 4938 22 elevation elevation NN cord-015021-pol2qm74 4938 23 of of IN cord-015021-pol2qm74 4938 24 pulmonary pulmonary JJ cord-015021-pol2qm74 4938 25 a a DT cord-015021-pol2qm74 4938 26 - - HYPH cord-015021-pol2qm74 4938 27 tocopherol tocopherol NN cord-015021-pol2qm74 4938 28 concentration concentration NN cord-015021-pol2qm74 4938 29 , , , cord-015021-pol2qm74 4938 30 accompanied accompany VBN cord-015021-pol2qm74 4938 31 by by IN cord-015021-pol2qm74 4938 32 a a DT cord-015021-pol2qm74 4938 33 concomitant concomitant JJ cord-015021-pol2qm74 4938 34 reduction reduction NN cord-015021-pol2qm74 4938 35 in in IN cord-015021-pol2qm74 4938 36 MPO MPO NNP cord-015021-pol2qm74 4938 37 activity activity NN cord-015021-pol2qm74 4938 38 and and CC cord-015021-pol2qm74 4938 39 reversal reversal NN cord-015021-pol2qm74 4938 40 of of IN cord-015021-pol2qm74 4938 41 PMAinduced pmainduced JJ cord-015021-pol2qm74 4938 42 changes change NNS cord-015021-pol2qm74 4938 43 in in IN cord-015021-pol2qm74 4938 44 lung lung NN cord-015021-pol2qm74 4938 45 edema edema NN cord-015021-pol2qm74 4938 46 , , , cord-015021-pol2qm74 4938 47 lipid lipid NN cord-015021-pol2qm74 4938 48 peroxidation peroxidation NN cord-015021-pol2qm74 4938 49 , , , cord-015021-pol2qm74 4938 50 ACE ACE NNP cord-015021-pol2qm74 4938 51 and and CC cord-015021-pol2qm74 4938 52 AKP AKP NNP cord-015021-pol2qm74 4938 53 activities activity NNS cord-015021-pol2qm74 4938 54 . . . cord-015021-pol2qm74 4939 1 These these DT cord-015021-pol2qm74 4939 2 results result NNS cord-015021-pol2qm74 4939 3 appear appear VBP cord-015021-pol2qm74 4939 4 to to TO cord-015021-pol2qm74 4939 5 demonstrate demonstrate VB cord-015021-pol2qm74 4939 6 that that IN cord-015021-pol2qm74 4939 7 the the DT cord-015021-pol2qm74 4939 8 intratracheal intratracheal NNP cord-015021-pol2qm74 4939 9 administration administration NNP cord-015021-pol2qm74 4939 10 of of IN cord-015021-pol2qm74 4939 11 a a DT cord-015021-pol2qm74 4939 12 liposome liposome NN cord-015021-pol2qm74 4939 13 - - HYPH cord-015021-pol2qm74 4939 14 associated associate VBN cord-015021-pol2qm74 4939 15 lipophilic lipophilic JJ cord-015021-pol2qm74 4939 16 antioxidant antioxidant NN cord-015021-pol2qm74 4939 17 , , , cord-015021-pol2qm74 4939 18 such such JJ cord-015021-pol2qm74 4939 19 as as IN cord-015021-pol2qm74 4939 20 a a DT cord-015021-pol2qm74 4939 21 - - HYPH cord-015021-pol2qm74 4939 22 tocopherol tocopherol NN cord-015021-pol2qm74 4939 23 , , , cord-015021-pol2qm74 4939 24 can can MD cord-015021-pol2qm74 4939 25 significantly significantly RB cord-015021-pol2qm74 4939 26 ameliorate ameliorate VB cord-015021-pol2qm74 4939 27 the the DT cord-015021-pol2qm74 4939 28 toxic toxic JJ cord-015021-pol2qm74 4939 29 effects effect NNS cord-015021-pol2qm74 4939 30 of of IN cord-015021-pol2qm74 4939 31 reactive reactive JJ cord-015021-pol2qm74 4939 32 oxygen oxygen NN cord-015021-pol2qm74 4939 33 species specie NNS cord-015021-pol2qm74 4939 34 , , , cord-015021-pol2qm74 4939 35 released release VBN cord-015021-pol2qm74 4939 36 from from IN cord-015021-pol2qm74 4939 37 PMAstimulated PMAstimulated NNP cord-015021-pol2qm74 4939 38 pulmonary pulmonary JJ cord-015021-pol2qm74 4939 39 target target NN cord-015021-pol2qm74 4939 40 cells cell NNS cord-015021-pol2qm74 4939 41 and and CC cord-015021-pol2qm74 4939 42 infiltrating infiltrate VBG cord-015021-pol2qm74 4939 43 neutrophils neutrophil NNS cord-015021-pol2qm74 4939 44 . . . cord-015021-pol2qm74 4940 1 JK JK NNP cord-015021-pol2qm74 4940 2 Wojcik Wojcik NNP cord-015021-pol2qm74 4940 3 , , , cord-015021-pol2qm74 4940 4 G G NNP cord-015021-pol2qm74 4940 5 Palasiewicz Palasiewicz NNP cord-015021-pol2qm74 4940 6 , , , cord-015021-pol2qm74 4940 7 W W NNP cord-015021-pol2qm74 4940 8 Roszkowski Roszkowski NNP cord-015021-pol2qm74 4940 9 Immunology Immunology NNP cord-015021-pol2qm74 4940 10 Department Department NNP cord-015021-pol2qm74 4940 11 , , , cord-015021-pol2qm74 4940 12 Institute Institute NNP cord-015021-pol2qm74 4940 13 of of IN cord-015021-pol2qm74 4940 14 Tuberculosis Tuberculosis NNP cord-015021-pol2qm74 4940 15 and and CC cord-015021-pol2qm74 4940 16 Lung Lung NNP cord-015021-pol2qm74 4940 17 Diseases~ Diseases~ . cord-015021-pol2qm74 4941 1 Warszawa Warszawa NNP cord-015021-pol2qm74 4941 2 , , , cord-015021-pol2qm74 4941 3 Poland Poland NNP cord-015021-pol2qm74 4941 4 , , , cord-015021-pol2qm74 4941 5 M M NNP cord-015021-pol2qm74 4941 6 ~ ~ NFP cord-015021-pol2qm74 4941 7 larhospital larhospital NNP cord-015021-pol2qm74 4941 8 , , , cord-015021-pol2qm74 4941 9 Eskilstuna Eskilstuna NNP cord-015021-pol2qm74 4941 10 , , , cord-015021-pol2qm74 4941 11 Sweden Sweden NNP cord-015021-pol2qm74 4941 12 . . . cord-015021-pol2qm74 4942 1 Introduction introduction NN cord-015021-pol2qm74 4942 2 : : : cord-015021-pol2qm74 4943 1 The the DT cord-015021-pol2qm74 4943 2 critical critical JJ cord-015021-pol2qm74 4943 3 point point NN cord-015021-pol2qm74 4943 4 in in IN cord-015021-pol2qm74 4943 5 neutrophil neutrophil NN cord-015021-pol2qm74 4943 6 migration migration NN cord-015021-pol2qm74 4943 7 to to IN cord-015021-pol2qm74 4943 8 the the DT cord-015021-pol2qm74 4943 9 alveolar alveolar JJ cord-015021-pol2qm74 4943 10 space space NN cord-015021-pol2qm74 4943 11 in in IN cord-015021-pol2qm74 4943 12 the the DT cord-015021-pol2qm74 4943 13 course course NN cord-015021-pol2qm74 4943 14 of of IN cord-015021-pol2qm74 4943 15 ARDS ARDS NNP cord-015021-pol2qm74 4943 16 is be VBZ cord-015021-pol2qm74 4943 17 the the DT cord-015021-pol2qm74 4943 18 attachment attachment NN cord-015021-pol2qm74 4943 19 between between IN cord-015021-pol2qm74 4943 20 giyeoproteins giyeoprotein NNS cord-015021-pol2qm74 4943 21 of of IN cord-015021-pol2qm74 4943 22 neotrophil neotrophil NNP cord-015021-pol2qm74 4943 23 membranes(sialyl membranes(sialyl DT cord-015021-pol2qm74 4943 24 Lewis Lewis NNP cord-015021-pol2qm74 4943 25 x x SYM cord-015021-pol2qm74 4943 26 carbohydrate carbohydrate NN cord-015021-pol2qm74 4943 27 epitope epitope NN cord-015021-pol2qm74 4943 28 containing contain VBG cord-015021-pol2qm74 4943 29 u u NNP cord-015021-pol2qm74 4943 30 - - HYPH cord-015021-pol2qm74 4943 31 l l NN cord-015021-pol2qm74 4943 32 - - HYPH cord-015021-pol2qm74 4943 33 fucose fucose NNP cord-015021-pol2qm74 4943 34 ) ) -RRB- cord-015021-pol2qm74 4943 35 and and CC cord-015021-pol2qm74 4943 36 lectin lectin NN cord-015021-pol2qm74 4943 37 domains domain NNS cord-015021-pol2qm74 4943 38 of of IN cord-015021-pol2qm74 4943 39 endothelial endothelial JJ cord-015021-pol2qm74 4943 40 P p NN cord-015021-pol2qm74 4943 41 and and CC cord-015021-pol2qm74 4943 42 E e NN cord-015021-pol2qm74 4943 43 selectins selectin NNS cord-015021-pol2qm74 4943 44 ( ( -LRB- cord-015021-pol2qm74 4943 45 GMP-140,ELAM gmp-140,elam NN cord-015021-pol2qm74 4943 46 - - HYPH cord-015021-pol2qm74 4943 47 I i NN cord-015021-pol2qm74 4943 48 ) ) -RRB- cord-015021-pol2qm74 4943 49 . . . cord-015021-pol2qm74 4944 1 A a DT cord-015021-pol2qm74 4944 2 potential potential JJ cord-015021-pol2qm74 4944 3 beneficial beneficial JJ cord-015021-pol2qm74 4944 4 therapeutic therapeutic JJ cord-015021-pol2qm74 4944 5 strategy strategy NN cord-015021-pol2qm74 4944 6 may may MD cord-015021-pol2qm74 4944 7 be be VB cord-015021-pol2qm74 4944 8 designeP designeP NNP cord-015021-pol2qm74 4944 9 to to TO cord-015021-pol2qm74 4944 10 suppress suppress VB cord-015021-pol2qm74 4944 11 neutrophil neutrophil NN cord-015021-pol2qm74 4944 12 recruitment recruitment NN cord-015021-pol2qm74 4944 13 to to IN cord-015021-pol2qm74 4944 14 the the DT cord-015021-pol2qm74 4944 15 lungs lung NNS cord-015021-pol2qm74 4944 16 by by IN cord-015021-pol2qm74 4944 17 preventing prevent VBG cord-015021-pol2qm74 4944 18 their -PRON- PRP$ cord-015021-pol2qm74 4944 19 rolling rolling NN cord-015021-pol2qm74 4944 20 and and CC cord-015021-pol2qm74 4944 21 attachment attachment NN cord-015021-pol2qm74 4944 22 to to IN cord-015021-pol2qm74 4944 23 the the DT cord-015021-pol2qm74 4944 24 pulmonary pulmonary JJ cord-015021-pol2qm74 4944 25 endothelial endothelial JJ cord-015021-pol2qm74 4944 26 cells cell NNS cord-015021-pol2qm74 4944 27 . . . cord-015021-pol2qm74 4945 1 ObjecLive ObjecLive NNP cord-015021-pol2qm74 4945 2 : : : cord-015021-pol2qm74 4946 1 To to TO cord-015021-pol2qm74 4946 2 investigate investigate VB cord-015021-pol2qm74 4946 3 if if IN cord-015021-pol2qm74 4946 4 tz tz NNP cord-015021-pol2qm74 4946 5 - - HYPH cord-015021-pol2qm74 4946 6 l l NN cord-015021-pol2qm74 4946 7 - - HYPH cord-015021-pol2qm74 4946 8 fueose fueose VBN cord-015021-pol2qm74 4946 9 prevent prevent JJ cord-015021-pol2qm74 4946 10 experiments experiment NNS cord-015021-pol2qm74 4946 11 pulmonary pulmonary JJ cord-015021-pol2qm74 4946 12 hypertension hypertension NN cord-015021-pol2qm74 4946 13 in in IN cord-015021-pol2qm74 4946 14 ARDS ARDS NNP cord-015021-pol2qm74 4946 15 as as IN cord-015021-pol2qm74 4946 16 effective effective JJ cord-015021-pol2qm74 4946 17 as as IN cord-015021-pol2qm74 4946 18 metylpredniselone metylpredniselone NNP cord-015021-pol2qm74 4946 19 . . . cord-015021-pol2qm74 4947 1 Methods method NNS cord-015021-pol2qm74 4947 2 : : : cord-015021-pol2qm74 4947 3 Only only RB cord-015021-pol2qm74 4947 4 healthy healthy JJ cord-015021-pol2qm74 4947 5 rabbits rabbit NNS cord-015021-pol2qm74 4947 6 ( ( -LRB- cord-015021-pol2qm74 4947 7 N-24 N-24 NNP cord-015021-pol2qm74 4947 8 ) ) -RRB- cord-015021-pol2qm74 4947 9 weighing weigh VBG cord-015021-pol2qm74 4947 10 5.D-5.5 5.d-5.5 CD cord-015021-pol2qm74 4947 11 kg kg NNP cord-015021-pol2qm74 4947 12 OaselinePaO>11 OaselinePaO>11 NNP cord-015021-pol2qm74 4947 13 kPa kPa NNP cord-015021-pol2qm74 4947 14 and and CC cord-015021-pol2qm74 4947 15 mean mean VB cord-015021-pol2qm74 4947 16 pulmonary pulmonary JJ cord-015021-pol2qm74 4947 17 arterial arterial JJ cord-015021-pol2qm74 4947 18 pressure pressure NN cord-015021-pol2qm74 4947 19 ( ( -LRB- cord-015021-pol2qm74 4947 20 MPAP) > $ cord-015021-pol2qm74 5065 49 20 20 CD cord-015021-pol2qm74 5065 50 adjacent adjacent JJ cord-015021-pol2qm74 5065 51 hepatocytes hepatocyte NNS cord-015021-pol2qm74 5065 52 within within IN cord-015021-pol2qm74 5065 53 60 60 CD cord-015021-pol2qm74 5065 54 seconds second NNS cord-015021-pol2qm74 5065 55 . . . cord-015021-pol2qm74 5066 1 During during IN cord-015021-pol2qm74 5066 2 stress stress NN cord-015021-pol2qm74 5066 3 conditions condition NNS cord-015021-pol2qm74 5066 4 such such JJ cord-015021-pol2qm74 5066 5 as as IN cord-015021-pol2qm74 5066 6 endotoxemia endotoxemia NN cord-015021-pol2qm74 5066 7 or or CC cord-015021-pol2qm74 5066 8 zymozan zymozan NN cord-015021-pol2qm74 5066 9 inflammation inflammation NN cord-015021-pol2qm74 5066 10 , , , cord-015021-pol2qm74 5066 11 expression expression NN cord-015021-pol2qm74 5066 12 of of IN cord-015021-pol2qm74 5066 13 Cx32 Cx32 NNP cord-015021-pol2qm74 5066 14 is be VBZ cord-015021-pol2qm74 5066 15 markedly markedly RB cord-015021-pol2qm74 5066 16 decreased decrease VBN cord-015021-pol2qm74 5066 17 while while IN cord-015021-pol2qm74 5066 18 the the DT cord-015021-pol2qm74 5066 19 secondary secondary JJ cord-015021-pol2qm74 5066 20 gap gap NN cord-015021-pol2qm74 5066 21 junction junction NN cord-015021-pol2qm74 5066 22 protein protein NN cord-015021-pol2qm74 5066 23 Cx26 Cx26 NNP cord-015021-pol2qm74 5066 24 is be VBZ cord-015021-pol2qm74 5066 25 either either CC cord-015021-pol2qm74 5066 26 unchanged unchanged JJ cord-015021-pol2qm74 5066 27 or or CC cord-015021-pol2qm74 5066 28 even even RB cord-015021-pol2qm74 5066 29 increased increase VBN cord-015021-pol2qm74 5066 30 . . . cord-015021-pol2qm74 5067 1 While while IN cord-015021-pol2qm74 5067 2 Cx Cx NNP cord-015021-pol2qm74 5067 3 26 26 CD cord-015021-pol2qm74 5067 4 readily readily RB cord-015021-pol2qm74 5067 5 effects effect VBZ cord-015021-pol2qm74 5067 6 electrical electrical JJ cord-015021-pol2qm74 5067 7 coupling coupling NN cord-015021-pol2qm74 5067 8 , , , cord-015021-pol2qm74 5067 9 molecules molecule NNS cord-015021-pol2qm74 5067 10 > > XX cord-015021-pol2qm74 5067 11 350 350 CD cord-015021-pol2qm74 5067 12 D d NN cord-015021-pol2qm74 5067 13 pass pass NN cord-015021-pol2qm74 5067 14 only only RB cord-015021-pol2qm74 5067 15 very very RB cord-015021-pol2qm74 5067 16 slowly slowly RB cord-015021-pol2qm74 5067 17 . . . cord-015021-pol2qm74 5068 1 This this DT cord-015021-pol2qm74 5068 2 would would MD cord-015021-pol2qm74 5068 3 result result VB cord-015021-pol2qm74 5068 4 in in IN cord-015021-pol2qm74 5068 5 restriciton restriciton NN cord-015021-pol2qm74 5068 6 of of IN cord-015021-pol2qm74 5068 7 transmission transmission NN cord-015021-pol2qm74 5068 8 of of IN cord-015021-pol2qm74 5068 9 moecules moecule NNS cord-015021-pol2qm74 5068 10 the the DT cord-015021-pol2qm74 5068 11 size size NN cord-015021-pol2qm74 5068 12 of of IN cord-015021-pol2qm74 5068 13 ATP ATP NNP cord-015021-pol2qm74 5068 14 or or CC cord-015021-pol2qm74 5068 15 cAMP camp NN cord-015021-pol2qm74 5068 16 . . . cord-015021-pol2qm74 5069 1 Since since IN cord-015021-pol2qm74 5069 2 inhibition inhibition NN cord-015021-pol2qm74 5069 3 of of IN cord-015021-pol2qm74 5069 4 gap gap NN cord-015021-pol2qm74 5069 5 junctions junction NNS cord-015021-pol2qm74 5069 6 also also RB cord-015021-pol2qm74 5069 7 attentuates attentuate VBZ cord-015021-pol2qm74 5069 8 metabolic metabolic JJ cord-015021-pol2qm74 5069 9 response response NN cord-015021-pol2qm74 5069 10 to to IN cord-015021-pol2qm74 5069 11 hormone hormone NN cord-015021-pol2qm74 5069 12 or or CC cord-015021-pol2qm74 5069 13 nerve nerve NN cord-015021-pol2qm74 5069 14 stimulation stimulation NN cord-015021-pol2qm74 5069 15 , , , cord-015021-pol2qm74 5069 16 it -PRON- PRP cord-015021-pol2qm74 5069 17 is be VBZ cord-015021-pol2qm74 5069 18 evident evident JJ cord-015021-pol2qm74 5069 19 that that IN cord-015021-pol2qm74 5069 20 modulation modulation NN cord-015021-pol2qm74 5069 21 of of IN cord-015021-pol2qm74 5069 22 hepatocyte hepatocyte NN cord-015021-pol2qm74 5069 23 hetereogeneity hetereogeneity NN cord-015021-pol2qm74 5069 24 by by IN cord-015021-pol2qm74 5069 25 gap gap NN cord-015021-pol2qm74 5069 26 junctions junction NNS cord-015021-pol2qm74 5069 27 must must MD cord-015021-pol2qm74 5069 28 be be VB cord-015021-pol2qm74 5069 29 considered consider VBN cord-015021-pol2qm74 5069 30 in in IN cord-015021-pol2qm74 5069 31 determining determine VBG cord-015021-pol2qm74 5069 32 the the DT cord-015021-pol2qm74 5069 33 mechanisms mechanism NNS cord-015021-pol2qm74 5069 34 of of IN cord-015021-pol2qm74 5069 35 metabolic metabolic JJ cord-015021-pol2qm74 5069 36 alterations alteration NNS cord-015021-pol2qm74 5069 37 during during IN cord-015021-pol2qm74 5069 38 stress stress NN cord-015021-pol2qm74 5069 39 . . . cord-015021-pol2qm74 5069 40 _SP cord-015021-pol2qm74 5070 1 Already already RB cord-015021-pol2qm74 5070 2 minor minor JJ cord-015021-pol2qm74 5070 3 haemorrhage haemorrhage NN cord-015021-pol2qm74 5070 4 decreases decrease VBZ cord-015021-pol2qm74 5070 5 portal portal JJ cord-015021-pol2qm74 5070 6 venous venous JJ cord-015021-pol2qm74 5070 7 blood blood NN cord-015021-pol2qm74 5070 8 supply supply NN cord-015021-pol2qm74 5070 9 to to IN cord-015021-pol2qm74 5070 10 the the DT cord-015021-pol2qm74 5070 11 fiver fiver NN cord-015021-pol2qm74 5070 12 and and CC cord-015021-pol2qm74 5070 13 the the DT cord-015021-pol2qm74 5070 14 reduction reduction NN cord-015021-pol2qm74 5070 15 in in IN cord-015021-pol2qm74 5070 16 portal portal JJ cord-015021-pol2qm74 5070 17 blood blood NN cord-015021-pol2qm74 5070 18 flow flow NN cord-015021-pol2qm74 5070 19 becomes become VBZ cord-015021-pol2qm74 5070 20 more more RBR cord-015021-pol2qm74 5070 21 pronounced pronounced JJ cord-015021-pol2qm74 5070 22 with with IN cord-015021-pol2qm74 5070 23 more more RBR cord-015021-pol2qm74 5070 24 profound profound JJ cord-015021-pol2qm74 5070 25 btood btood NN cord-015021-pol2qm74 5070 26 loss loss NN cord-015021-pol2qm74 5070 27 . . . cord-015021-pol2qm74 5071 1 Severe severe JJ cord-015021-pol2qm74 5071 2 hacmorrhagic hacmorrhagic NNP cord-015021-pol2qm74 5071 3 hypovolemia hypovolemia NN cord-015021-pol2qm74 5071 4 also also RB cord-015021-pol2qm74 5071 5 reduces reduce VBZ cord-015021-pol2qm74 5071 6 hepatic hepatic JJ cord-015021-pol2qm74 5071 7 arterial arterial JJ cord-015021-pol2qm74 5071 8 blood blood NN cord-015021-pol2qm74 5071 9 supply supply NN cord-015021-pol2qm74 5071 10 which which WDT cord-015021-pol2qm74 5071 11 , , , cord-015021-pol2qm74 5071 12 however however RB cord-015021-pol2qm74 5071 13 , , , cord-015021-pol2qm74 5071 14 is be VBZ cord-015021-pol2qm74 5071 15 maintained maintain VBN cord-015021-pol2qm74 5071 16 over over IN cord-015021-pol2qm74 5071 17 a a DT cord-015021-pol2qm74 5071 18 vide vide NN cord-015021-pol2qm74 5071 19 range range NN cord-015021-pol2qm74 5071 20 of of IN cord-015021-pol2qm74 5071 21 haemorthage haemorthage NN cord-015021-pol2qm74 5071 22 . . . cord-015021-pol2qm74 5072 1 The the DT cord-015021-pol2qm74 5072 2 net net JJ cord-015021-pol2qm74 5072 3 effect effect NN cord-015021-pol2qm74 5072 4 of of IN cord-015021-pol2qm74 5072 5 blood blood NN cord-015021-pol2qm74 5072 6 loss loss NN cord-015021-pol2qm74 5072 7 is be VBZ cord-015021-pol2qm74 5072 8 a a DT cord-015021-pol2qm74 5072 9 reduction reduction NN cord-015021-pol2qm74 5072 10 in in IN cord-015021-pol2qm74 5072 11 liver liver NN cord-015021-pol2qm74 5072 12 oxygee oxygee NN cord-015021-pol2qm74 5072 13 supply supply NN cord-015021-pol2qm74 5072 14 and and CC cord-015021-pol2qm74 5072 15 this this DT cord-015021-pol2qm74 5072 16 reduction reduction NN cord-015021-pol2qm74 5072 17 is be VBZ cord-015021-pol2qm74 5072 18 in in IN cord-015021-pol2qm74 5072 19 proportion proportion NN cord-015021-pol2qm74 5072 20 to to IN cord-015021-pol2qm74 5072 21 the the DT cord-015021-pol2qm74 5072 22 vulume vulume NN cord-015021-pol2qm74 5072 23 Iossed Iossed NNP cord-015021-pol2qm74 5072 24 . . . cord-015021-pol2qm74 5073 1 However however RB cord-015021-pol2qm74 5073 2 , , , cord-015021-pol2qm74 5073 3 oxygen oxygen NN cord-015021-pol2qm74 5073 4 supply supply NN cord-015021-pol2qm74 5073 5 to to IN cord-015021-pol2qm74 5073 6 the the DT cord-015021-pol2qm74 5073 7 liver liver NN cord-015021-pol2qm74 5073 8 exceeds exceed VBZ cord-015021-pol2qm74 5073 9 the the DT cord-015021-pol2qm74 5073 10 demands demand NNS cord-015021-pol2qm74 5073 11 of of IN cord-015021-pol2qm74 5073 12 the the DT cord-015021-pol2qm74 5073 13 normal normal JJ cord-015021-pol2qm74 5073 14 liver liver NN cord-015021-pol2qm74 5073 15 and and CC cord-015021-pol2qm74 5073 16 this this DT cord-015021-pol2qm74 5073 17 is be VBZ cord-015021-pol2qm74 5073 18 the the DT cord-015021-pol2qm74 5073 19 ca~ ca~ NN cord-015021-pol2qm74 5073 20 stilt stilt NN cord-015021-pol2qm74 5073 21 following follow VBG cord-015021-pol2qm74 5073 22 reduction reduction NN cord-015021-pol2qm74 5073 23 of of IN cord-015021-pol2qm74 5073 24 30 30 CD cord-015021-pol2qm74 5073 25 % % NN cord-015021-pol2qm74 5073 26 of of IN cord-015021-pol2qm74 5073 27 blood blood NN cord-015021-pol2qm74 5073 28 volume volume NN cord-015021-pol2qm74 5073 29 . . . cord-015021-pol2qm74 5074 1 The the DT cord-015021-pol2qm74 5074 2 situation situation NN cord-015021-pol2qm74 5074 3 in in IN cord-015021-pol2qm74 5074 4 sepsis sepsis NN cord-015021-pol2qm74 5074 5 is be VBZ cord-015021-pol2qm74 5074 6 more more RBR cord-015021-pol2qm74 5074 7 complicated complicated JJ cord-015021-pol2qm74 5074 8 . . . cord-015021-pol2qm74 5075 1 Po Po NNP cord-015021-pol2qm74 5076 1 ~l ~l NNP cord-015021-pol2qm74 5076 2 venous venous JJ cord-015021-pol2qm74 5076 3 supply supply NN cord-015021-pol2qm74 5076 4 to to IN cord-015021-pol2qm74 5076 5 the the DT cord-015021-pol2qm74 5076 6 liver liver NN cord-015021-pol2qm74 5076 7 is be VBZ cord-015021-pol2qm74 5076 8 redur.~i redur.~i NNS cord-015021-pol2qm74 5076 9 fairly fairly RB cord-015021-pol2qm74 5076 10 early early RB cord-015021-pol2qm74 5076 11 following follow VBG cord-015021-pol2qm74 5076 12 normovolemic normovolemic JJ cord-015021-pol2qm74 5076 13 sepsis sepsis NN cord-015021-pol2qm74 5076 14 while while IN cord-015021-pol2qm74 5076 15 hepatic hepatic JJ cord-015021-pol2qm74 5076 16 arterial arterial JJ cord-015021-pol2qm74 5076 17 blood blood NN cord-015021-pol2qm74 5076 18 supply supply NN cord-015021-pol2qm74 5076 19 is be VBZ cord-015021-pol2qm74 5076 20 maintained maintain VBN cord-015021-pol2qm74 5076 21 at at IN cord-015021-pol2qm74 5076 22 le,~t le,~t NNP cord-015021-pol2qm74 5076 23 initialIy initialIy NNP cord-015021-pol2qm74 5076 24 , , , cord-015021-pol2qm74 5076 25 Oxygen oxygen NN cord-015021-pol2qm74 5076 26 saturation saturation NN cord-015021-pol2qm74 5076 27 might may MD cord-015021-pol2qm74 5076 28 be be VB cord-015021-pol2qm74 5076 29 maintained maintain VBN cord-015021-pol2qm74 5076 30 in in IN cord-015021-pol2qm74 5076 31 arterial arterial JJ cord-015021-pol2qm74 5076 32 blood blood NN cord-015021-pol2qm74 5076 33 but but CC cord-015021-pol2qm74 5076 34 may may MD cord-015021-pol2qm74 5076 35 also also RB cord-015021-pol2qm74 5076 36 be be VB cord-015021-pol2qm74 5076 37 slightly slightly RB cord-015021-pol2qm74 5076 38 reduced reduce VBN cord-015021-pol2qm74 5076 39 during during IN cord-015021-pol2qm74 5076 40 sepsis sepsis NN cord-015021-pol2qm74 5076 41 , , , cord-015021-pol2qm74 5076 42 Oxygen oxygen NN cord-015021-pol2qm74 5076 43 saturation saturation NN cord-015021-pol2qm74 5076 44 of of IN cord-015021-pol2qm74 5076 45 portal portal JJ cord-015021-pol2qm74 5076 46 venous venous JJ cord-015021-pol2qm74 5076 47 blood blood NN cord-015021-pol2qm74 5076 48 is be VBZ cord-015021-pol2qm74 5076 49 significantly significantly RB cord-015021-pol2qm74 5076 50 reduced reduce VBN cord-015021-pol2qm74 5076 51 during during IN cord-015021-pol2qm74 5076 52 sepsis sepsis NN cord-015021-pol2qm74 5076 53 due due IN cord-015021-pol2qm74 5076 54 to to IN cord-015021-pol2qm74 5076 55 increased increase VBN cord-015021-pol2qm74 5076 56 extraction extraction NN cord-015021-pol2qm74 5076 57 of of IN cord-015021-pol2qm74 5076 58 the the DT cord-015021-pol2qm74 5076 59 intestines intestine NNS cord-015021-pol2qm74 5076 60 . . . cord-015021-pol2qm74 5077 1 Therefore therefore RB cord-015021-pol2qm74 5077 2 oxygea oxygea VB cord-015021-pol2qm74 5077 3 delivery delivery NN cord-015021-pol2qm74 5077 4 to to IN cord-015021-pol2qm74 5077 5 the the DT cord-015021-pol2qm74 5077 6 liver liver NN cord-015021-pol2qm74 5077 7 during during IN cord-015021-pol2qm74 5077 8 sepsis sepsis NN cord-015021-pol2qm74 5077 9 becomes become VBZ cord-015021-pol2qm74 5077 10 sigalfkzntly sigalfkzntly RB cord-015021-pol2qm74 5077 11 reduced reduce VBN cord-015021-pol2qm74 5077 12 . . . cord-015021-pol2qm74 5078 1 At at IN cord-015021-pol2qm74 5078 2 the the DT cord-015021-pol2qm74 5078 3 s,~ne s,~ne NNP cord-015021-pol2qm74 5078 4 time time NN cord-015021-pol2qm74 5078 5 and and CC cord-015021-pol2qm74 5078 6 for for IN cord-015021-pol2qm74 5078 7 mai.v.ly mai.v.ly DT cord-015021-pol2qm74 5078 8 unknown unknown JJ cord-015021-pol2qm74 5078 9 reasons reason NNS cord-015021-pol2qm74 5078 10 the the DT cord-015021-pol2qm74 5078 11 need need NN cord-015021-pol2qm74 5078 12 for for IN cord-015021-pol2qm74 5078 13 oxygen oxygen NN cord-015021-pol2qm74 5078 14 becomes become VBZ cord-015021-pol2qm74 5078 15 significantly significantly RB cord-015021-pol2qm74 5078 16 increased increase VBN cord-015021-pol2qm74 5078 17 in in IN cord-015021-pol2qm74 5078 18 the the DT cord-015021-pol2qm74 5078 19 ~-~ptic ~-~ptic JJ cord-015021-pol2qm74 5078 20 liver liver NN cord-015021-pol2qm74 5078 21 . . . cord-015021-pol2qm74 5079 1 As as IN cord-015021-pol2qm74 5079 2 a a DT cord-015021-pol2qm74 5079 3 consequence consequence NN cord-015021-pol2qm74 5079 4 liver liver NN cord-015021-pol2qm74 5079 5 oxygen oxygen NN cord-015021-pol2qm74 5079 6 consumption consumption NN cord-015021-pol2qm74 5079 7 becomes become VBZ cord-015021-pol2qm74 5079 8 flow flow NN cord-015021-pol2qm74 5079 9 dependent dependent JJ cord-015021-pol2qm74 5079 10 and and CC cord-015021-pol2qm74 5079 11 the the DT cord-015021-pol2qm74 5079 12 liver liver NN cord-015021-pol2qm74 5079 13 is be VBZ cord-015021-pol2qm74 5079 14 likely likely JJ cord-015021-pol2qm74 5079 15 to to TO cord-015021-pol2qm74 5079 16 suffer suffer VB cord-015021-pol2qm74 5079 17 from from IN cord-015021-pol2qm74 5079 18 ischemia ischemia NN cord-015021-pol2qm74 5079 19 during during IN cord-015021-pol2qm74 5079 20 septic septic JJ cord-015021-pol2qm74 5079 21 conditions condition NNS cord-015021-pol2qm74 5079 22 . . . cord-015021-pol2qm74 5080 1 $ $ $ cord-015021-pol2qm74 5080 2 94 94 CD cord-015021-pol2qm74 5081 1 Although although IN cord-015021-pol2qm74 5081 2 liver liver NN cord-015021-pol2qm74 5081 3 failure failure NN cord-015021-pol2qm74 5081 4 is be VBZ cord-015021-pol2qm74 5081 5 well well RB cord-015021-pol2qm74 5081 6 recognized recognize VBN cord-015021-pol2qm74 5081 7 in in IN cord-015021-pol2qm74 5081 8 sepsis sepsis NN cord-015021-pol2qm74 5081 9 , , , cord-015021-pol2qm74 5081 10 it -PRON- PRP cord-015021-pol2qm74 5081 11 is be VBZ cord-015021-pol2qm74 5081 12 generally generally RB cord-015021-pol2qm74 5081 13 thought think VBN cord-015021-pol2qm74 5081 14 to to TO cord-015021-pol2qm74 5081 15 be be VB cord-015021-pol2qm74 5081 16 a a DT cord-015021-pol2qm74 5081 17 late late JJ cord-015021-pol2qm74 5081 18 complication complication NN cord-015021-pol2qm74 5081 19 following follow VBG cord-015021-pol2qm74 5081 20 pulmonary pulmonary JJ cord-015021-pol2qm74 5081 21 and and CC cord-015021-pol2qm74 5081 22 renal renal JJ cord-015021-pol2qm74 5081 23 failure failure NN cord-015021-pol2qm74 5081 24 . . . cord-015021-pol2qm74 5082 1 Jaundice jaundice NN cord-015021-pol2qm74 5082 2 , , , cord-015021-pol2qm74 5082 3 hypoglycemia hypoglycemia NN cord-015021-pol2qm74 5082 4 , , , cord-015021-pol2qm74 5082 5 encephalopathy encephalopathy NN cord-015021-pol2qm74 5082 6 and and CC cord-015021-pol2qm74 5082 7 bleeding bleed VBG cord-015021-pol2qm74 5082 8 secondary secondary JJ cord-015021-pol2qm74 5082 9 to to IN cord-015021-pol2qm74 5082 10 low low JJ cord-015021-pol2qm74 5082 11 levels level NNS cord-015021-pol2qm74 5082 12 of of IN cord-015021-pol2qm74 5082 13 liver liver NN cord-015021-pol2qm74 5082 14 - - HYPH cord-015021-pol2qm74 5082 15 synthesizing synthesize VBG cord-015021-pol2qm74 5082 16 clotting clotting NN cord-015021-pol2qm74 5082 17 factors factor NNS cord-015021-pol2qm74 5082 18 are be VBP cord-015021-pol2qm74 5082 19 , , , cord-015021-pol2qm74 5082 20 however however RB cord-015021-pol2qm74 5082 21 , , , cord-015021-pol2qm74 5082 22 signs sign NNS cord-015021-pol2qm74 5082 23 of of IN cord-015021-pol2qm74 5082 24 rather rather RB cord-015021-pol2qm74 5082 25 severe severe JJ cord-015021-pol2qm74 5082 26 end end NN cord-015021-pol2qm74 5082 27 - - HYPH cord-015021-pol2qm74 5082 28 stage stage NN cord-015021-pol2qm74 5082 29 hepatic hepatic JJ cord-015021-pol2qm74 5082 30 failure failure NN cord-015021-pol2qm74 5082 31 . . . cord-015021-pol2qm74 5083 1 Furthermore furthermore RB cord-015021-pol2qm74 5083 2 , , , cord-015021-pol2qm74 5083 3 elevated elevated JJ cord-015021-pol2qm74 5083 4 liver liver NN cord-015021-pol2qm74 5083 5 enzymes enzyme NNS cord-015021-pol2qm74 5083 6 ( ( -LRB- cord-015021-pol2qm74 5083 7 SGOT SGOT NNP cord-015021-pol2qm74 5083 8 and and CC cord-015021-pol2qm74 5083 9 SGPT SGPT NNP cord-015021-pol2qm74 5083 10 ) ) -RRB- cord-015021-pol2qm74 5083 11 represent represent VBP cord-015021-pol2qm74 5083 12 hepatucyte hepatucyte NNP cord-015021-pol2qm74 5083 13 damage damage NN cord-015021-pol2qm74 5083 14 and and CC cord-015021-pol2qm74 5083 15 not not RB cord-015021-pol2qm74 5083 16 hepatocellular hepatocellular JJ cord-015021-pol2qm74 5083 17 dysfunction dysfunction NN cord-015021-pol2qm74 5083 18 . . . cord-015021-pol2qm74 5084 1 In in IN cord-015021-pol2qm74 5084 2 view view NN cord-015021-pol2qm74 5084 3 of of IN cord-015021-pol2qm74 5084 4 this this DT cord-015021-pol2qm74 5084 5 , , , cord-015021-pol2qm74 5084 6 a a DT cord-015021-pol2qm74 5084 7 more more RBR cord-015021-pol2qm74 5084 8 sensitive sensitive JJ cord-015021-pol2qm74 5084 9 indicator indicator NN cord-015021-pol2qm74 5084 10 of of IN cord-015021-pol2qm74 5084 11 hepatic hepatic JJ cord-015021-pol2qm74 5084 12 function function NN cord-015021-pol2qm74 5084 13 is be VBZ cord-015021-pol2qm74 5084 14 desirable desirable JJ cord-015021-pol2qm74 5084 15 in in IN cord-015021-pol2qm74 5084 16 order order NN cord-015021-pol2qm74 5084 17 to to TO cord-015021-pol2qm74 5084 18 detect detect VB cord-015021-pol2qm74 5084 19 early early JJ cord-015021-pol2qm74 5084 20 hepatic hepatic JJ cord-015021-pol2qm74 5084 21 abnormality abnormality NN cord-015021-pol2qm74 5084 22 . . . cord-015021-pol2qm74 5085 1 In in IN cord-015021-pol2qm74 5085 2 this this DT cord-015021-pol2qm74 5085 3 respect respect NN cord-015021-pol2qm74 5085 4 , , , cord-015021-pol2qm74 5085 5 indocyanine indocyanine NN cord-015021-pol2qm74 5085 6 green green JJ cord-015021-pol2qm74 5085 7 ( ( -LRB- cord-015021-pol2qm74 5085 8 ICG ICG NNP cord-015021-pol2qm74 5085 9 ) ) -RRB- cord-015021-pol2qm74 5085 10 is be VBZ cord-015021-pol2qm74 5085 11 a a DT cord-015021-pol2qm74 5085 12 tricarbocyanine tricarbocyanine JJ cord-015021-pol2qm74 5085 13 dye dye NN cord-015021-pol2qm74 5085 14 that that WDT cord-015021-pol2qm74 5085 15 possesses possess VBZ cord-015021-pol2qm74 5085 16 several several JJ cord-015021-pol2qm74 5085 17 properties property NNS cord-015021-pol2qm74 5085 18 which which WDT cord-015021-pol2qm74 5085 19 makes make VBZ cord-015021-pol2qm74 5085 20 it -PRON- PRP cord-015021-pol2qm74 5085 21 particularly particularly RB cord-015021-pol2qm74 5085 22 valuable valuable JJ cord-015021-pol2qm74 5085 23 inthe inthe JJ cord-015021-pol2qm74 5085 24 assessment assessment NN cord-015021-pol2qm74 5085 25 ofhepatic ofhepatic JJ cord-015021-pol2qm74 5085 26 function function NN cord-015021-pol2qm74 5085 27 . . . cord-015021-pol2qm74 5086 1 This this DT cord-015021-pol2qm74 5086 2 dye dye NN cord-015021-pol2qm74 5086 3 is be VBZ cord-015021-pol2qm74 5086 4 bound bind VBN cord-015021-pol2qm74 5086 5 m m CD cord-015021-pol2qm74 5086 6 albumin albumin NN cord-015021-pol2qm74 5086 7 and and CC cord-015021-pol2qm74 5086 8 is be VBZ cord-015021-pol2qm74 5086 9 cleared clear VBN cord-015021-pol2qm74 5086 10 exclusively exclusively RB cord-015021-pol2qm74 5086 11 by by IN cord-015021-pol2qm74 5086 12 the the DT cord-015021-pol2qm74 5086 13 liver liver NN cord-015021-pol2qm74 5086 14 through through IN cord-015021-pol2qm74 5086 15 an an DT cord-015021-pol2qm74 5086 16 energydependent energydependent NN cord-015021-pol2qm74 5086 17 membrane membrane NN cord-015021-pol2qm74 5086 18 transport transport NN cord-015021-pol2qm74 5086 19 process process NN cord-015021-pol2qm74 5086 20 and and CC cord-015021-pol2qm74 5086 21 is be VBZ cord-015021-pol2qm74 5086 22 nontoxic nontoxic JJ cord-015021-pol2qm74 5086 23 at at IN cord-015021-pol2qm74 5086 24 lower low JJR cord-015021-pol2qm74 5086 25 doses dose NNS cord-015021-pol2qm74 5086 26 . . . cord-015021-pol2qm74 5087 1 We -PRON- PRP cord-015021-pol2qm74 5087 2 propose propose VBP cord-015021-pol2qm74 5087 3 that that IN cord-015021-pol2qm74 5087 4 maximal maximal JJ cord-015021-pol2qm74 5087 5 velocity velocity NN cord-015021-pol2qm74 5087 6 ( ( -LRB- cord-015021-pol2qm74 5087 7 Vm~ Vm~ NNP cord-015021-pol2qm74 5087 8 , , , cord-015021-pol2qm74 5087 9 ) ) -RRB- cord-015021-pol2qm74 5087 10 of of IN cord-015021-pol2qm74 5087 11 ICG ICG NNP cord-015021-pol2qm74 5087 12 clearance clearance NN cord-015021-pol2qm74 5087 13 is be VBZ cord-015021-pol2qm74 5087 14 a a DT cord-015021-pol2qm74 5087 15 valuable valuable JJ cord-015021-pol2qm74 5087 16 measure measure NN cord-015021-pol2qm74 5087 17 of of IN cord-015021-pol2qm74 5087 18 active active JJ cord-015021-pol2qm74 5087 19 hepatocellular hepatocellular JJ cord-015021-pol2qm74 5087 20 function function NN cord-015021-pol2qm74 5087 21 , , , cord-015021-pol2qm74 5087 22 since since IN cord-015021-pol2qm74 5087 23 the the DT cord-015021-pol2qm74 5087 24 total total JJ cord-015021-pol2qm74 5087 25 concentration concentration NN cord-015021-pol2qm74 5087 26 of of IN cord-015021-pol2qm74 5087 27 functioning function VBG cord-015021-pol2qm74 5087 28 receptors receptor NNS cord-015021-pol2qm74 5087 29 is be VBZ cord-015021-pol2qm74 5087 30 directly directly RB cord-015021-pol2qm74 5087 31 proportional proportional JJ cord-015021-pol2qm74 5087 32 to to IN cord-015021-pol2qm74 5087 33 Vm~. vm~. NN cord-015021-pol2qm74 5088 1 We -PRON- PRP cord-015021-pol2qm74 5088 2 have have VBP cord-015021-pol2qm74 5088 3 utilized utilize VBN cord-015021-pol2qm74 5088 4 a a DT cord-015021-pol2qm74 5088 5 fiber fiber NN cord-015021-pol2qm74 5088 6 optic optic JJ cord-015021-pol2qm74 5088 7 catheter catheter NN cord-015021-pol2qm74 5088 8 and and CC cord-015021-pol2qm74 5088 9 an an DT cord-015021-pol2qm74 5088 10 in in IN cord-015021-pol2qm74 5088 11 vivo vivo FW cord-015021-pol2qm74 5088 12 hemoreflectometar hemoreflectometar NNP cord-015021-pol2qm74 5088 13 to to TO cord-015021-pol2qm74 5088 14 continuously continuously RB cord-015021-pol2qm74 5088 15 measure measure VB cord-015021-pol2qm74 5088 16 the the DT cord-015021-pol2qm74 5088 17 administered administer VBN cord-015021-pol2qm74 5088 18 ICG ICG NNP cord-015021-pol2qm74 5088 19 in in IN cord-015021-pol2qm74 5088 20 vivo vivo NN cord-015021-pol2qm74 5088 21 and and CC cord-015021-pol2qm74 5088 22 consequently consequently RB cord-015021-pol2qm74 5088 23 determine determine VB cord-015021-pol2qm74 5088 24 its -PRON- PRP$ cord-015021-pol2qm74 5088 25 clearance clearance NN cord-015021-pol2qm74 5088 26 without without IN cord-015021-pol2qm74 5088 27 the the DT cord-015021-pol2qm74 5088 28 need need NN cord-015021-pol2qm74 5088 29 of of IN cord-015021-pol2qm74 5088 30 blood blood NN cord-015021-pol2qm74 5088 31 sampling sampling NN cord-015021-pol2qm74 5088 32 . . . cord-015021-pol2qm74 5089 1 Using use VBG cord-015021-pol2qm74 5089 2 this this DT cord-015021-pol2qm74 5089 3 technique technique NN cord-015021-pol2qm74 5089 4 , , , cord-015021-pol2qm74 5089 5 we -PRON- PRP cord-015021-pol2qm74 5089 6 have have VBP cord-015021-pol2qm74 5089 7 found find VBN cord-015021-pol2qm74 5089 8 that that IN cord-015021-pol2qm74 5089 9 in in IN cord-015021-pol2qm74 5089 10 the the DT cord-015021-pol2qm74 5089 11 early early JJ cord-015021-pol2qm74 5089 12 stages stage NNS cord-015021-pol2qm74 5089 13 of of IN cord-015021-pol2qm74 5089 14 sepsis sepsis NN cord-015021-pol2qm74 5089 15 ( ( -LRB- cord-015021-pol2qm74 5089 16 i.e. i.e. FW cord-015021-pol2qm74 5089 17 , , , cord-015021-pol2qm74 5089 18 2 2 CD cord-015021-pol2qm74 5089 19 and and CC cord-015021-pol2qm74 5089 20 5 5 CD cord-015021-pol2qm74 5089 21 h h NN cord-015021-pol2qm74 5089 22 following follow VBG cord-015021-pol2qm74 5089 23 cecal cecal JJ cord-015021-pol2qm74 5089 24 ligation ligation NN cord-015021-pol2qm74 5089 25 and and CC cord-015021-pol2qm74 5089 26 puncture puncture NN cord-015021-pol2qm74 5089 27 ) ) -RRB- cord-015021-pol2qm74 5089 28 , , , cord-015021-pol2qm74 5089 29 the the DT cord-015021-pol2qm74 5089 30 Vm~ Vm~ NNP cord-015021-pol2qm74 5089 31 and and CC cord-015021-pol2qm74 5089 32 kinetic kinetic JJ cord-015021-pol2qm74 5089 33 constant constant NN cord-015021-pol2qm74 5089 34 ( ( -LRB- cord-015021-pol2qm74 5089 35 K= K= NNP cord-015021-pol2qm74 5089 36 ) ) -RRB- cord-015021-pol2qm74 5089 37 of of IN cord-015021-pol2qm74 5089 38 ICG ICG NNP cord-015021-pol2qm74 5089 39 clearance clearance NN cord-015021-pol2qm74 5089 40 was be VBD cord-015021-pol2qm74 5089 41 significantly significantly RB cord-015021-pol2qm74 5089 42 depressed depressed JJ cord-015021-pol2qm74 5089 43 . . . cord-015021-pol2qm74 5090 1 It -PRON- PRP cord-015021-pol2qm74 5090 2 should should MD cord-015021-pol2qm74 5090 3 be be VB cord-015021-pol2qm74 5090 4 noted note VBN cord-015021-pol2qm74 5090 5 that that IN cord-015021-pol2qm74 5090 6 at at IN cord-015021-pol2qm74 5090 7 this this DT cord-015021-pol2qm74 5090 8 stage stage NN cord-015021-pol2qm74 5090 9 of of IN cord-015021-pol2qm74 5090 10 sepsis sepsis NN cord-015021-pol2qm74 5090 11 , , , cord-015021-pol2qm74 5090 12 there there EX cord-015021-pol2qm74 5090 13 was be VBD cord-015021-pol2qm74 5090 14 no no DT cord-015021-pol2qm74 5090 15 elevation elevation NN cord-015021-pol2qm74 5090 16 in in IN cord-015021-pol2qm74 5090 17 serum serum NN cord-015021-pol2qm74 5090 18 enzyme enzyme NN cord-015021-pol2qm74 5090 19 levels level NNS cord-015021-pol2qm74 5090 20 . . . cord-015021-pol2qm74 5091 1 Furthermore furthermore RB cord-015021-pol2qm74 5091 2 , , , cord-015021-pol2qm74 5091 3 hepatic hepatic JJ cord-015021-pol2qm74 5091 4 blood blood NN cord-015021-pol2qm74 5091 5 flow flow NN cord-015021-pol2qm74 5091 6 and and CC cord-015021-pol2qm74 5091 7 cardiac cardiac JJ cord-015021-pol2qm74 5091 8 output output NN cord-015021-pol2qm74 5091 9 increased increase VBD cord-015021-pol2qm74 5091 10 at at IN cord-015021-pol2qm74 5091 11 the the DT cord-015021-pol2qm74 5091 12 above above RB cord-015021-pol2qm74 5091 13 mentioned mention VBN cord-015021-pol2qm74 5091 14 time time NN cord-015021-pol2qm74 5091 15 points point NNS cord-015021-pol2qm74 5091 16 . . . cord-015021-pol2qm74 5092 1 Thus thus RB cord-015021-pol2qm74 5092 2 , , , cord-015021-pol2qm74 5092 3 the the DT cord-015021-pol2qm74 5092 4 extremely extremely RB cord-015021-pol2qm74 5092 5 early early JJ cord-015021-pol2qm74 5092 6 depression depression NN cord-015021-pol2qm74 5092 7 in in IN cord-015021-pol2qm74 5092 8 active active JJ cord-015021-pol2qm74 5092 9 hepatocellular hepatocellular JJ cord-015021-pol2qm74 5092 10 function function NN cord-015021-pol2qm74 5092 11 in in IN cord-015021-pol2qm74 5092 12 sepsis sepsis NN cord-015021-pol2qm74 5092 13 , , , cord-015021-pol2qm74 5092 14 despite despite IN cord-015021-pol2qm74 5092 15 the the DT cord-015021-pol2qm74 5092 16 increased increase VBN cord-015021-pol2qm74 5092 17 hepatic hepatic JJ cord-015021-pol2qm74 5092 18 blood blood NN cord-015021-pol2qm74 5092 19 flow flow NN cord-015021-pol2qm74 5092 20 and and CC cord-015021-pol2qm74 5092 21 cardiac cardiac JJ cord-015021-pol2qm74 5092 22 output output NN cord-015021-pol2qm74 5092 23 , , , cord-015021-pol2qm74 5092 24 may may MD cord-015021-pol2qm74 5092 25 form form VB cord-015021-pol2qm74 5092 26 the the DT cord-015021-pol2qm74 5092 27 basis basis NN cord-015021-pol2qm74 5092 28 for for IN cord-015021-pol2qm74 5092 29 cellular cellular JJ cord-015021-pol2qm74 5092 30 dysfunctions dysfunction NNS cord-015021-pol2qm74 5092 31 leading lead VBG cord-015021-pol2qm74 5092 32 to to IN cord-015021-pol2qm74 5092 33 multiple multiple JJ cord-015021-pol2qm74 5092 34 organ organ NN cord-015021-pol2qm74 5092 35 failure failure NN cord-015021-pol2qm74 5092 36 during during IN cord-015021-pol2qm74 5092 37 sepsis sepsis NN cord-015021-pol2qm74 5092 38 . . . cord-015021-pol2qm74 5093 1 Additional additional JJ cord-015021-pol2qm74 5093 2 studies study NNS cord-015021-pol2qm74 5093 3 indicated indicate VBD cord-015021-pol2qm74 5093 4 that that IN cord-015021-pol2qm74 5093 5 following follow VBG cord-015021-pol2qm74 5093 6 hemorrhage hemorrhage NN cord-015021-pol2qm74 5093 7 , , , cord-015021-pol2qm74 5093 8 active active JJ cord-015021-pol2qm74 5093 9 hepatocellular hepatocellular JJ cord-015021-pol2qm74 5093 10 function function NN cord-015021-pol2qm74 5093 11 was be VBD cord-015021-pol2qm74 5093 12 markedly markedly RB cord-015021-pol2qm74 5093 13 depressed depressed JJ cord-015021-pol2qm74 5093 14 . . . cord-015021-pol2qm74 5094 1 This this DT cord-015021-pol2qm74 5094 2 returned return VBD cord-015021-pol2qm74 5094 3 to to IN cord-015021-pol2qm74 5094 4 prehemorrhage prehemorrhage NN cord-015021-pol2qm74 5094 5 levels level NNS cord-015021-pol2qm74 5094 6 after after IN cord-015021-pol2qm74 5094 7 Ringers ringer NNS cord-015021-pol2qm74 5094 8 lactate lactate VBP cord-015021-pol2qm74 5094 9 resuscitation resuscitation NN cord-015021-pol2qm74 5094 10 , , , cord-015021-pol2qm74 5094 11 however however RB cord-015021-pol2qm74 5094 12 , , , cord-015021-pol2qm74 5094 13 this this DT cord-015021-pol2qm74 5094 14 function function NN cord-015021-pol2qm74 5094 15 was be VBD cord-015021-pol2qm74 5094 16 not not RB cord-015021-pol2qm74 5094 17 maintained maintain VBN cord-015021-pol2qm74 5094 18 and and CC cord-015021-pol2qm74 5094 19 decreased decrease VBD cord-015021-pol2qm74 5094 20 significantly significantly RB cord-015021-pol2qm74 5094 21 after after IN cord-015021-pol2qm74 5094 22 fluid fluid JJ cord-015021-pol2qm74 5094 23 resuscitation resuscitation NN cord-015021-pol2qm74 5094 24 . . . cord-015021-pol2qm74 5095 1 Nevertheless nevertheless RB cord-015021-pol2qm74 5095 2 , , , cord-015021-pol2qm74 5095 3 the the DT cord-015021-pol2qm74 5095 4 depressed depressed JJ cord-015021-pol2qm74 5095 5 active active JJ cord-015021-pol2qm74 5095 6 hepatocelinlar hepatocelinlar NNP cord-015021-pol2qm74 5095 7 function function NN cord-015021-pol2qm74 5095 8 following follow VBG cord-015021-pol2qm74 5095 9 hemorrhage hemorrhage NN cord-015021-pol2qm74 5095 10 was be VBD cord-015021-pol2qm74 5095 11 markedly markedly RB cord-015021-pol2qm74 5095 12 improved improve VBN cord-015021-pol2qm74 5095 13 by by IN cord-015021-pol2qm74 5095 14 post post JJ cord-015021-pol2qm74 5095 15 - - JJ cord-015021-pol2qm74 5095 16 treatment treatment NN cord-015021-pol2qm74 5095 17 of of IN cord-015021-pol2qm74 5095 18 animals animal NNS cord-015021-pol2qm74 5095 19 with with IN cord-015021-pol2qm74 5095 20 either either CC cord-015021-pol2qm74 5095 21 ATP ATP NNP cord-015021-pol2qm74 5095 22 - - HYPH cord-015021-pol2qm74 5095 23 MgCI2 MgCI2 NNP cord-015021-pol2qm74 5095 24 , , , cord-015021-pol2qm74 5095 25 peutoxifylline peutoxifylline NN cord-015021-pol2qm74 5095 26 or or CC cord-015021-pol2qm74 5095 27 diltiazem diltiazem NN cord-015021-pol2qm74 5095 28 . . . cord-015021-pol2qm74 5096 1 Thus thus RB cord-015021-pol2qm74 5096 2 , , , cord-015021-pol2qm74 5096 3 the the DT cord-015021-pol2qm74 5096 4 use use NN cord-015021-pol2qm74 5096 5 of of IN cord-015021-pol2qm74 5096 6 ICG ICG NNP cord-015021-pol2qm74 5096 7 clearance clearance NN cord-015021-pol2qm74 5096 8 provides provide VBZ cord-015021-pol2qm74 5096 9 an an DT cord-015021-pol2qm74 5096 10 early early JJ cord-015021-pol2qm74 5096 11 sensitive sensitive JJ cord-015021-pol2qm74 5096 12 indicator indicator NN cord-015021-pol2qm74 5096 13 of of IN cord-015021-pol2qm74 5096 14 hepatic hepatic JJ cord-015021-pol2qm74 5096 15 abnormality abnormality NN cord-015021-pol2qm74 5096 16 during during IN cord-015021-pol2qm74 5096 17 sepsis sepsis NN cord-015021-pol2qm74 5096 18 and and CC cord-015021-pol2qm74 5096 19 following follow VBG cord-015021-pol2qm74 5096 20 hemorrhage hemorrhage NN cord-015021-pol2qm74 5096 21 and and CC cord-015021-pol2qm74 5096 22 this this DT cord-015021-pol2qm74 5096 23 method method NN cord-015021-pol2qm74 5096 24 should should MD cord-015021-pol2qm74 5096 25 be be VB cord-015021-pol2qm74 5096 26 used use VBN cord-015021-pol2qm74 5096 27 , , , cord-015021-pol2qm74 5096 28 not not RB cord-015021-pol2qm74 5096 29 only only RB cord-015021-pol2qm74 5096 30 experimentally experimentally RB cord-015021-pol2qm74 5096 31 , , , cord-015021-pol2qm74 5096 32 but but CC cord-015021-pol2qm74 5096 33 also also RB cord-015021-pol2qm74 5096 34 in in IN cord-015021-pol2qm74 5096 35 the the DT cord-015021-pol2qm74 5096 36 clinical clinical JJ cord-015021-pol2qm74 5096 37 arena arena NN cord-015021-pol2qm74 5096 38 for for IN cord-015021-pol2qm74 5096 39 the the DT cord-015021-pol2qm74 5096 40 early early JJ cord-015021-pol2qm74 5096 41 detection detection NN cord-015021-pol2qm74 5096 42 of of IN cord-015021-pol2qm74 5096 43 hepatocellular hepatocellular JJ cord-015021-pol2qm74 5096 44 abnormality abnormality NN cord-015021-pol2qm74 5096 45 . . . cord-015021-pol2qm74 5097 1 Although although IN cord-015021-pol2qm74 5097 2 multiple multiple JJ cord-015021-pol2qm74 5097 3 organ organ NN cord-015021-pol2qm74 5097 4 dysfunction dysfunction NN cord-015021-pol2qm74 5097 5 syndrome syndrome NN cord-015021-pol2qm74 5097 6 ( ( -LRB- cord-015021-pol2qm74 5097 7 MODS MODS NNP cord-015021-pol2qm74 5097 8 ) ) -RRB- cord-015021-pol2qm74 5097 9 remains remain VBZ cord-015021-pol2qm74 5097 10 a a DT cord-015021-pol2qm74 5097 11 major major JJ cord-015021-pol2qm74 5097 12 cause cause NN cord-015021-pol2qm74 5097 13 of of IN cord-015021-pol2qm74 5097 14 mortality mortality NN cord-015021-pol2qm74 5097 15 and and CC cord-015021-pol2qm74 5097 16 morbidity morbidity NN cord-015021-pol2qm74 5097 17 in in IN cord-015021-pol2qm74 5097 18 intensive intensive JJ cord-015021-pol2qm74 5097 19 care care NN cord-015021-pol2qm74 5097 20 units unit NNS cord-015021-pol2qm74 5097 21 , , , cord-015021-pol2qm74 5097 22 very very RB cord-015021-pol2qm74 5097 23 little little JJ cord-015021-pol2qm74 5097 24 is be VBZ cord-015021-pol2qm74 5097 25 known know VBN cord-015021-pol2qm74 5097 26 about about IN cord-015021-pol2qm74 5097 27 the the DT cord-015021-pol2qm74 5097 28 mechanisms mechanism NNS cord-015021-pol2qm74 5097 29 that that WDT cord-015021-pol2qm74 5097 30 precipitate precipitate VBP cord-015021-pol2qm74 5097 31 its -PRON- PRP$ cord-015021-pol2qm74 5097 32 development development NN cord-015021-pol2qm74 5097 33 . . . cord-015021-pol2qm74 5098 1 Since since IN cord-015021-pol2qm74 5098 2 an an DT cord-015021-pol2qm74 5098 3 episode episode NN cord-015021-pol2qm74 5098 4 of of IN cord-015021-pol2qm74 5098 5 inadequate inadequate JJ cord-015021-pol2qm74 5098 6 tissue tissue NN cord-015021-pol2qm74 5098 7 oxygenation oxygenation NN cord-015021-pol2qm74 5098 8 is be VBZ cord-015021-pol2qm74 5098 9 considered consider VBN cord-015021-pol2qm74 5098 10 to to TO cord-015021-pol2qm74 5098 11 be be VB cord-015021-pol2qm74 5098 12 the the DT cord-015021-pol2qm74 5098 13 trigger trigger NN cord-015021-pol2qm74 5098 14 for for IN cord-015021-pol2qm74 5098 15 MODS mods NN cord-015021-pol2qm74 5098 16 , , , cord-015021-pol2qm74 5098 17 we -PRON- PRP cord-015021-pol2qm74 5098 18 have have VBP cord-015021-pol2qm74 5098 19 proposed propose VBN cord-015021-pol2qm74 5098 20 that that IN cord-015021-pol2qm74 5098 21 a a DT cord-015021-pol2qm74 5098 22 primary primary JJ cord-015021-pol2qm74 5098 23 localized localize VBN cord-015021-pol2qm74 5098 24 injury injury NN cord-015021-pol2qm74 5098 25 such such JJ cord-015021-pol2qm74 5098 26 as as IN cord-015021-pol2qm74 5098 27 ischemia ischemia NN cord-015021-pol2qm74 5098 28 / / SYM cord-015021-pol2qm74 5098 29 reperfusion reperfusion NN cord-015021-pol2qm74 5098 30 may may MD cord-015021-pol2qm74 5098 31 be be VB cord-015021-pol2qm74 5098 32 sufficient sufficient JJ cord-015021-pol2qm74 5098 33 to to TO cord-015021-pol2qm74 5098 34 cause cause VB cord-015021-pol2qm74 5098 35 a a DT cord-015021-pol2qm74 5098 36 change change NN cord-015021-pol2qm74 5098 37 of of IN cord-015021-pol2qm74 5098 38 gene gene NN cord-015021-pol2qm74 5098 39 expression expression NN cord-015021-pol2qm74 5098 40 of of IN cord-015021-pol2qm74 5098 41 remote remote JJ cord-015021-pol2qm74 5098 42 and and CC cord-015021-pol2qm74 5098 43 apparently apparently RB cord-015021-pol2qm74 5098 44 unaffected unaffected JJ cord-015021-pol2qm74 5098 45 organs organ NNS cord-015021-pol2qm74 5098 46 . . . cord-015021-pol2qm74 5099 1 Such such JJ cord-015021-pol2qm74 5099 2 modulation modulation NN cord-015021-pol2qm74 5099 3 of of IN cord-015021-pol2qm74 5099 4 remote remote JJ cord-015021-pol2qm74 5099 5 organ organ NN cord-015021-pol2qm74 5099 6 gene gene NN cord-015021-pol2qm74 5099 7 expression expression NN cord-015021-pol2qm74 5099 8 may may MD cord-015021-pol2qm74 5099 9 decrease decrease VB cord-015021-pol2qm74 5099 10 the the DT cord-015021-pol2qm74 5099 11 organ organ NN cord-015021-pol2qm74 5099 12 's 's POS cord-015021-pol2qm74 5099 13 tolerance tolerance NN cord-015021-pol2qm74 5099 14 to to IN cord-015021-pol2qm74 5099 15 a a DT cord-015021-pol2qm74 5099 16 subsequent subsequent JJ cord-015021-pol2qm74 5099 17 stress stress NN cord-015021-pol2qm74 5099 18 contributing contribute VBG cord-015021-pol2qm74 5099 19 to to IN cord-015021-pol2qm74 5099 20 the the DT cord-015021-pol2qm74 5099 21 development development NN cord-015021-pol2qm74 5099 22 of of IN cord-015021-pol2qm74 5099 23 MOFS MOFS NNP cord-015021-pol2qm74 5099 24 . . . cord-015021-pol2qm74 5100 1 To to TO cord-015021-pol2qm74 5100 2 test test VB cord-015021-pol2qm74 5100 3 this this DT cord-015021-pol2qm74 5100 4 hypothesis hypothesis NN cord-015021-pol2qm74 5100 5 , , , cord-015021-pol2qm74 5100 6 rats rat NNS cord-015021-pol2qm74 5100 7 were be VBD cord-015021-pol2qm74 5100 8 subjected subject VBN cord-015021-pol2qm74 5100 9 to to IN cord-015021-pol2qm74 5100 10 hepatic hepatic JJ cord-015021-pol2qm74 5100 11 regional regional JJ cord-015021-pol2qm74 5100 12 ischemia ischemia NN cord-015021-pol2qm74 5100 13 by by IN cord-015021-pol2qm74 5100 14 clamping clamp VBG cord-015021-pol2qm74 5100 15 the the DT cord-015021-pol2qm74 5100 16 blood blood NN cord-015021-pol2qm74 5100 17 flow flow NN cord-015021-pol2qm74 5100 18 ( ( -LRB- cord-015021-pol2qm74 5100 19 hepatic hepatic JJ cord-015021-pol2qm74 5100 20 artery artery NN cord-015021-pol2qm74 5100 21 and and CC cord-015021-pol2qm74 5100 22 portal portal JJ cord-015021-pol2qm74 5100 23 venous venous JJ cord-015021-pol2qm74 5100 24 inflow inflow NN cord-015021-pol2qm74 5100 25 ) ) -RRB- cord-015021-pol2qm74 5100 26 of of IN cord-015021-pol2qm74 5100 27 the the DT cord-015021-pol2qm74 5100 28 left left JJ cord-015021-pol2qm74 5100 29 and and CC cord-015021-pol2qm74 5100 30 median median JJ cord-015021-pol2qm74 5100 31 liver liver NN cord-015021-pol2qm74 5100 32 lobes lobe NNS cord-015021-pol2qm74 5100 33 . . . cord-015021-pol2qm74 5101 1 Intestinal intestinal JJ cord-015021-pol2qm74 5101 2 congestion congestion NN cord-015021-pol2qm74 5101 3 was be VBD cord-015021-pol2qm74 5101 4 prevented prevent VBN cord-015021-pol2qm74 5101 5 by by IN cord-015021-pol2qm74 5101 6 allowing allow VBG cord-015021-pol2qm74 5101 7 flow flow NN cord-015021-pol2qm74 5101 8 through through IN cord-015021-pol2qm74 5101 9 the the DT cord-015021-pol2qm74 5101 10 smaller small JJR cord-015021-pol2qm74 5101 11 right right JJ cord-015021-pol2qm74 5101 12 and and CC cord-015021-pol2qm74 5101 13 caudate caudate NN cord-015021-pol2qm74 5101 14 lobes lobe NNS cord-015021-pol2qm74 5101 15 . . . cord-015021-pol2qm74 5102 1 After after IN cord-015021-pol2qm74 5102 2 60 60 CD cord-015021-pol2qm74 5102 3 minutes minute NNS cord-015021-pol2qm74 5102 4 of of IN cord-015021-pol2qm74 5102 5 ischemia ischemia NN cord-015021-pol2qm74 5102 6 , , , cord-015021-pol2qm74 5102 7 the the DT cord-015021-pol2qm74 5102 8 clamp clamp NN cord-015021-pol2qm74 5102 9 was be VBD cord-015021-pol2qm74 5102 10 removed remove VBN cord-015021-pol2qm74 5102 11 and and CC cord-015021-pol2qm74 5102 12 the the DT cord-015021-pol2qm74 5102 13 blood blood NN cord-015021-pol2qm74 5102 14 flow flow NN cord-015021-pol2qm74 5102 15 restored restore VBN cord-015021-pol2qm74 5102 16 . . . cord-015021-pol2qm74 5103 1 The the DT cord-015021-pol2qm74 5103 2 animals animal NNS cord-015021-pol2qm74 5103 3 were be VBD cord-015021-pol2qm74 5103 4 allowed allow VBN cord-015021-pol2qm74 5103 5 to to TO cord-015021-pol2qm74 5103 6 recover recover VB cord-015021-pol2qm74 5103 7 for for IN cord-015021-pol2qm74 5103 8 1 1 CD cord-015021-pol2qm74 5103 9 , , , cord-015021-pol2qm74 5103 10 4 4 CD cord-015021-pol2qm74 5103 11 and and CC cord-015021-pol2qm74 5103 12 24 24 CD cord-015021-pol2qm74 5103 13 hours hour NNS cord-015021-pol2qm74 5103 14 . . . cord-015021-pol2qm74 5104 1 Kidneys kidney NNS cord-015021-pol2qm74 5104 2 were be VBD cord-015021-pol2qm74 5104 3 removed remove VBN cord-015021-pol2qm74 5104 4 , , , cord-015021-pol2qm74 5104 5 total total JJ cord-015021-pol2qm74 5104 6 RNA RNA NNP cord-015021-pol2qm74 5104 7 was be VBD cord-015021-pol2qm74 5104 8 isolated isolate VBN cord-015021-pol2qm74 5104 9 and and CC cord-015021-pol2qm74 5104 10 poly(A poly(a JJ cord-015021-pol2qm74 5104 11 ) ) -RRB- cord-015021-pol2qm74 5104 12 ÷ ÷ NN cord-015021-pol2qm74 5104 13 selected select VBN cord-015021-pol2qm74 5104 14 by by IN cord-015021-pol2qm74 5104 15 affinity affinity NN cord-015021-pol2qm74 5104 16 chromatography chromatography NN cord-015021-pol2qm74 5104 17 on on IN cord-015021-pol2qm74 5104 18 oligo(dT oligo(dt CD cord-015021-pol2qm74 5104 19 ) ) -RRB- cord-015021-pol2qm74 5104 20 columns column NNS cord-015021-pol2qm74 5104 21 . . . cord-015021-pol2qm74 5105 1 Message message NN cord-015021-pol2qm74 5105 2 was be VBD cord-015021-pol2qm74 5105 3 in in IN cord-015021-pol2qm74 5105 4 vitro vitro FW cord-015021-pol2qm74 5105 5 translated translate VBN cord-015021-pol2qm74 5105 6 using use VBG cord-015021-pol2qm74 5105 7 rabbit rabbit NN cord-015021-pol2qm74 5105 8 reticulocyte reticulocyte NNP cord-015021-pol2qm74 5105 9 Iysates Iysates NNPS cord-015021-pol2qm74 5105 10 in in IN cord-015021-pol2qm74 5105 11 the the DT cord-015021-pol2qm74 5105 12 presence presence NN cord-015021-pol2qm74 5105 13 of of IN cord-015021-pol2qm74 5105 14 radioactive radioactive JJ cord-015021-pol2qm74 5105 15 amino amino NN cord-015021-pol2qm74 5105 16 acids acid NNS cord-015021-pol2qm74 5105 17 . . . cord-015021-pol2qm74 5106 1 The the DT cord-015021-pol2qm74 5106 2 gene gene NN cord-015021-pol2qm74 5106 3 products product NNS cord-015021-pol2qm74 5106 4 ( ( -LRB- cord-015021-pol2qm74 5106 5 radiolabeled radiolabele VBN cord-015021-pol2qm74 5106 6 polypeptides polypeptide NNS cord-015021-pol2qm74 5106 7 ) ) -RRB- cord-015021-pol2qm74 5106 8 were be VBD cord-015021-pol2qm74 5106 9 fractionated fractionate VBN cord-015021-pol2qm74 5106 10 by by IN cord-015021-pol2qm74 5106 11 two two CD cord-015021-pol2qm74 5106 12 dimensional dimensional JJ cord-015021-pol2qm74 5106 13 gel gel NN cord-015021-pol2qm74 5106 14 electrophoresis electrophoresis NN cord-015021-pol2qm74 5106 15 , , , cord-015021-pol2qm74 5106 16 and and CC cord-015021-pol2qm74 5106 17 visualized visualize VBN cord-015021-pol2qm74 5106 18 by by IN cord-015021-pol2qm74 5106 19 fluorography fluorography NNP cord-015021-pol2qm74 5106 20 . . . cord-015021-pol2qm74 5107 1 Analyses analysis NNS cord-015021-pol2qm74 5107 2 of of IN cord-015021-pol2qm74 5107 3 the the DT cord-015021-pol2qm74 5107 4 two two CD cord-015021-pol2qm74 5107 5 dimensional dimensional JJ cord-015021-pol2qm74 5107 6 fluorograms fluorogram NNS cord-015021-pol2qm74 5107 7 indicate indicate VBP cord-015021-pol2qm74 5107 8 that that IN cord-015021-pol2qm74 5107 9 there there EX cord-015021-pol2qm74 5107 10 is be VBZ cord-015021-pol2qm74 5107 11 a a DT cord-015021-pol2qm74 5107 12 dramatic dramatic JJ cord-015021-pol2qm74 5107 13 change change NN cord-015021-pol2qm74 5107 14 in in IN cord-015021-pol2qm74 5107 15 the the DT cord-015021-pol2qm74 5107 16 electrophoretic electrophoretic JJ cord-015021-pol2qm74 5107 17 pattern pattern NN cord-015021-pol2qm74 5107 18 of of IN cord-015021-pol2qm74 5107 19 in in FW cord-015021-pol2qm74 5107 20 vitro vitro FW cord-015021-pol2qm74 5107 21 translated translate VBN cord-015021-pol2qm74 5107 22 products product NNS cord-015021-pol2qm74 5107 23 in in IN cord-015021-pol2qm74 5107 24 samples sample NNS cord-015021-pol2qm74 5107 25 corresponding correspond VBG cord-015021-pol2qm74 5107 26 to to IN cord-015021-pol2qm74 5107 27 kidneys kidney NNS cord-015021-pol2qm74 5107 28 obtained obtain VBN cord-015021-pol2qm74 5107 29 after after IN cord-015021-pol2qm74 5107 30 60 60 CD cord-015021-pol2qm74 5107 31 minutes minute NNS cord-015021-pol2qm74 5107 32 of of IN cord-015021-pol2qm74 5107 33 hepatic hepatic JJ cord-015021-pol2qm74 5107 34 ischemia ischemia NN cord-015021-pol2qm74 5107 35 and and CC cord-015021-pol2qm74 5107 36 24 24 CD cord-015021-pol2qm74 5107 37 hours hour NNS cord-015021-pol2qm74 5107 38 of of IN cord-015021-pol2qm74 5107 39 reperfusion reperfusion NN cord-015021-pol2qm74 5107 40 with with IN cord-015021-pol2qm74 5107 41 respect respect NN cord-015021-pol2qm74 5107 42 to to IN cord-015021-pol2qm74 5107 43 kidney kidney NN cord-015021-pol2qm74 5107 44 samples sample NNS cord-015021-pol2qm74 5107 45 obtained obtain VBN cord-015021-pol2qm74 5107 46 after after IN cord-015021-pol2qm74 5107 47 sham sham NN cord-015021-pol2qm74 5107 48 operation operation NN cord-015021-pol2qm74 5107 49 or or CC cord-015021-pol2qm74 5107 50 from from IN cord-015021-pol2qm74 5107 51 control control NN cord-015021-pol2qm74 5107 52 rats rat NNS cord-015021-pol2qm74 5107 53 . . . cord-015021-pol2qm74 5108 1 The the DT cord-015021-pol2qm74 5108 2 latter latter JJ cord-015021-pol2qm74 5108 3 were be VBD cord-015021-pol2qm74 5108 4 not not RB cord-015021-pol2qm74 5108 5 subjected subject VBN cord-015021-pol2qm74 5108 6 to to IN cord-015021-pol2qm74 5108 7 any any DT cord-015021-pol2qm74 5108 8 surgical surgical JJ cord-015021-pol2qm74 5108 9 manipulation manipulation NN cord-015021-pol2qm74 5108 10 . . . cord-015021-pol2qm74 5109 1 These these DT cord-015021-pol2qm74 5109 2 studies study NNS cord-015021-pol2qm74 5109 3 suggest suggest VBP cord-015021-pol2qm74 5109 4 that that IN cord-015021-pol2qm74 5109 5 the the DT cord-015021-pol2qm74 5109 6 gene gene NN cord-015021-pol2qm74 5109 7 expression expression NN cord-015021-pol2qm74 5109 8 of of IN cord-015021-pol2qm74 5109 9 the the DT cord-015021-pol2qm74 5109 10 kidneys kidney NNS cord-015021-pol2qm74 5109 11 is be VBZ cord-015021-pol2qm74 5109 12 specifically specifically RB cord-015021-pol2qm74 5109 13 modified modify VBN cord-015021-pol2qm74 5109 14 after after IN cord-015021-pol2qm74 5109 15 a a DT cord-015021-pol2qm74 5109 16 remote remote JJ cord-015021-pol2qm74 5109 17 organ organ NN cord-015021-pol2qm74 5109 18 injury injury NN cord-015021-pol2qm74 5109 19 ( ( -LRB- cord-015021-pol2qm74 5109 20 hepatic hepatic JJ cord-015021-pol2qm74 5109 21 ischemia ischemia NN cord-015021-pol2qm74 5109 22 / / SYM cord-015021-pol2qm74 5109 23 reperfusion reperfusion NN cord-015021-pol2qm74 5109 24 ) ) -RRB- cord-015021-pol2qm74 5109 25 . . . cord-015021-pol2qm74 5110 1 We -PRON- PRP cord-015021-pol2qm74 5110 2 speculate speculate VBP cord-015021-pol2qm74 5110 3 that that IN cord-015021-pol2qm74 5110 4 this this DT cord-015021-pol2qm74 5110 5 change change NN cord-015021-pol2qm74 5110 6 of of IN cord-015021-pol2qm74 5110 7 gene gene NN cord-015021-pol2qm74 5110 8 expression expression NN cord-015021-pol2qm74 5110 9 in in IN cord-015021-pol2qm74 5110 10 kidneys kidney NNS cord-015021-pol2qm74 5110 11 after after IN cord-015021-pol2qm74 5110 12 an an DT cord-015021-pol2qm74 5110 13 indirect indirect JJ cord-015021-pol2qm74 5110 14 injury injury NN cord-015021-pol2qm74 5110 15 may may MD cord-015021-pol2qm74 5110 16 be be VB cord-015021-pol2qm74 5110 17 part part NN cord-015021-pol2qm74 5110 18 of of IN cord-015021-pol2qm74 5110 19 the the DT cord-015021-pol2qm74 5110 20 early early JJ cord-015021-pol2qm74 5110 21 events event NNS cord-015021-pol2qm74 5110 22 leading lead VBG cord-015021-pol2qm74 5110 23 to to IN cord-015021-pol2qm74 5110 24 the the DT cord-015021-pol2qm74 5110 25 development development NN cord-015021-pol2qm74 5110 26 of of IN cord-015021-pol2qm74 5110 27 MODS mod NNS cord-015021-pol2qm74 5110 28 . . . cord-015021-pol2qm74 5111 1 A a DT cord-015021-pol2qm74 5111 2 priming prime VBG cord-015021-pol2qm74 5111 3 event event NN cord-015021-pol2qm74 5111 4 , , , cord-015021-pol2qm74 5111 5 e.g. e.g. IN cord-015021-pol2qm74 5111 6 local local JJ cord-015021-pol2qm74 5111 7 ischemia ischemia NN cord-015021-pol2qm74 5111 8 , , , cord-015021-pol2qm74 5111 9 in in IN cord-015021-pol2qm74 5111 10 combination combination NN cord-015021-pol2qm74 5111 11 with with IN cord-015021-pol2qm74 5111 12 a a DT cord-015021-pol2qm74 5111 13 second second JJ cord-015021-pol2qm74 5111 14 insult insult NN cord-015021-pol2qm74 5111 15 , , , cord-015021-pol2qm74 5111 16 e.g. e.g. RB cord-015021-pol2qm74 5111 17 sepsis sepsis NN cord-015021-pol2qm74 5111 18 , , , cord-015021-pol2qm74 5111 19 may may MD cord-015021-pol2qm74 5111 20 amplify amplify VB cord-015021-pol2qm74 5111 21 a a DT cord-015021-pol2qm74 5111 22 host host NN cord-015021-pol2qm74 5111 23 's 's POS cord-015021-pol2qm74 5111 24 response response NN cord-015021-pol2qm74 5111 25 and and CC cord-015021-pol2qm74 5111 26 lead lead VB cord-015021-pol2qm74 5111 27 to to IN cord-015021-pol2qm74 5111 28 multiple multiple JJ cord-015021-pol2qm74 5111 29 organ organ NN cord-015021-pol2qm74 5111 30 failure failure NN cord-015021-pol2qm74 5111 31 . . . cord-015021-pol2qm74 5112 1 To to TO cord-015021-pol2qm74 5112 2 better well RBR cord-015021-pol2qm74 5112 3 understand understand VB cord-015021-pol2qm74 5112 4 the the DT cord-015021-pol2qm74 5112 5 mechanisms mechanism NNS cord-015021-pol2qm74 5112 6 involved involve VBN cord-015021-pol2qm74 5112 7 in in IN cord-015021-pol2qm74 5112 8 the the DT cord-015021-pol2qm74 5112 9 pathophysiology pathophysiology NN cord-015021-pol2qm74 5112 10 , , , cord-015021-pol2qm74 5112 11 male male JJ cord-015021-pol2qm74 5112 12 Fischer Fischer NNP cord-015021-pol2qm74 5112 13 rats rat NNS cord-015021-pol2qm74 5112 14 were be VBD cord-015021-pol2qm74 5112 15 subjected subject VBN cord-015021-pol2qm74 5112 16 to to IN cord-015021-pol2qm74 5112 17 20 20 CD cord-015021-pol2qm74 5112 18 min min NN cord-015021-pol2qm74 5112 19 of of IN cord-015021-pol2qm74 5112 20 hepatic hepatic JJ cord-015021-pol2qm74 5112 21 ischemia ischemia NN cord-015021-pol2qm74 5112 22 followed follow VBN cord-015021-pol2qm74 5112 23 by by IN cord-015021-pol2qm74 5112 24 reperfusion reperfusion NN cord-015021-pol2qm74 5112 25 ( ( -LRB- cord-015021-pol2qm74 5112 26 RP RP NNP cord-015021-pol2qm74 5112 27 ) ) -RRB- cord-015021-pol2qm74 5112 28 and and CC cord-015021-pol2qm74 5112 29 injection injection NN cord-015021-pol2qm74 5112 30 of of IN cord-015021-pol2qm74 5112 31 0.5 0.5 CD cord-015021-pol2qm74 5112 32 mg mg NNP cord-015021-pol2qm74 5112 33 / / SYM cord-015021-pol2qm74 5112 34 kg kg NNP cord-015021-pol2qm74 5112 35 Salmonella Salmonella NNP cord-015021-pol2qm74 5112 36 enteritidis enteritidis NN cord-015021-pol2qm74 5112 37 endotoxin endotoxin NN cord-015021-pol2qm74 5112 38 ( ( -LRB- cord-015021-pol2qm74 5112 39 ET ET NNP cord-015021-pol2qm74 5112 40 ) ) -RRB- cord-015021-pol2qm74 5112 41 at at IN cord-015021-pol2qm74 5112 42 30 30 CD cord-015021-pol2qm74 5112 43 min min NN cord-015021-pol2qm74 5112 44 of of IN cord-015021-pol2qm74 5112 45 RP RP NNP cord-015021-pol2qm74 5112 46 . . . cord-015021-pol2qm74 5113 1 ET ET NNP cord-015021-pol2qm74 5113 2 injection injection NN cord-015021-pol2qm74 5113 3 potentiated potentiate VBD cord-015021-pol2qm74 5113 4 the the DT cord-015021-pol2qm74 5113 5 postischemic postischemic NNP cord-015021-pol2qm74 5113 6 liver liver NN cord-015021-pol2qm74 5113 7 injury injury NN cord-015021-pol2qm74 5113 8 as as IN cord-015021-pol2qm74 5113 9 indicated indicate VBN cord-015021-pol2qm74 5113 10 by by IN cord-015021-pol2qm74 5113 11 histopathology histopathology NN cord-015021-pol2qm74 5113 12 and and CC cord-015021-pol2qm74 5113 13 an an DT cord-015021-pol2qm74 5113 14 increase increase NN cord-015021-pol2qm74 5113 15 of of IN cord-015021-pol2qm74 5113 16 plasma plasma NN cord-015021-pol2qm74 5113 17 ALT alt NN cord-015021-pol2qm74 5113 18 activities activity NNS cord-015021-pol2qm74 5113 19 from from IN cord-015021-pol2qm74 5113 20 870 870 CD cord-015021-pol2qm74 5113 21 + + SYM cord-015021-pol2qm74 5113 22 122 122 CD cord-015021-pol2qm74 5113 23 U U NNP cord-015021-pol2qm74 5113 24 / / SYM cord-015021-pol2qm74 5113 25 L l NN cord-015021-pol2qm74 5113 26 ( ( -LRB- cord-015021-pol2qm74 5113 27 I i NN cord-015021-pol2qm74 5113 28 / / SYM cord-015021-pol2qm74 5113 29 RP RP NNP cord-015021-pol2qm74 5113 30 only only RB cord-015021-pol2qm74 5113 31 ) ) -RRB- cord-015021-pol2qm74 5113 32 to to IN cord-015021-pol2qm74 5113 33 3900 3900 CD cord-015021-pol2qm74 5113 34 + + SYM cord-015021-pol2qm74 5113 35 470 470 CD cord-015021-pol2qm74 5113 36 U U NNP cord-015021-pol2qm74 5113 37 / / SYM cord-015021-pol2qm74 5113 38 L l NN cord-015021-pol2qm74 5113 39 at at IN cord-015021-pol2qm74 5113 40 4h 4h CD cord-015021-pol2qm74 5113 41 RP RP NNP cord-015021-pol2qm74 5113 42 . . . cord-015021-pol2qm74 5114 1 Inhibition inhibition NN cord-015021-pol2qm74 5114 2 of of IN cord-015021-pol2qm74 5114 3 Kupffer Kupffer NNP cord-015021-pol2qm74 5114 4 cells cell NNS cord-015021-pol2qm74 5114 5 ( ( -LRB- cord-015021-pol2qm74 5114 6 KC KC NNP cord-015021-pol2qm74 5114 7 ) ) -RRB- cord-015021-pol2qm74 5114 8 with with IN cord-015021-pol2qm74 5114 9 gadolinium gadolinium NN cord-015021-pol2qm74 5114 10 chloride chloride NN cord-015021-pol2qm74 5114 11 ( ( -LRB- cord-015021-pol2qm74 5114 12 7 7 CD cord-015021-pol2qm74 5114 13 mg mg NNP cord-015021-pol2qm74 5114 14 / / SYM cord-015021-pol2qm74 5114 15 kg kg NNP cord-015021-pol2qm74 5114 16 ) ) -RRB- cord-015021-pol2qm74 5114 17 attenuated attenuated JJ cord-015021-pol2qm74 5114 18 liver liver NN cord-015021-pol2qm74 5114 19 injury injury NN cord-015021-pol2qm74 5114 20 in in IN cord-015021-pol2qm74 5114 21 this this DT cord-015021-pol2qm74 5114 22 model model NN cord-015021-pol2qm74 5114 23 by by IN cord-015021-pol2qm74 5114 24 70 70 CD cord-015021-pol2qm74 5114 25 % % NN cord-015021-pol2qm74 5114 26 , , , cord-015021-pol2qm74 5114 27 however however RB cord-015021-pol2qm74 5114 28 , , , cord-015021-pol2qm74 5114 29 monoclonal monoclonal JJ cord-015021-pol2qm74 5114 30 antibodies antibody NNS cord-015021-pol2qm74 5114 31 ( ( -LRB- cord-015021-pol2qm74 5114 32 CL26 CL26 NNP cord-015021-pol2qm74 5114 33 , , , cord-015021-pol2qm74 5114 34 WT3 WT3 NNP cord-015021-pol2qm74 5114 35 ) ) -RRB- cord-015021-pol2qm74 5114 36 directed direct VBD cord-015021-pol2qm74 5114 37 against against IN cord-015021-pol2qm74 5114 38 adhesion adhesion NN cord-015021-pol2qm74 5114 39 molecules molecule NNS cord-015021-pol2qm74 5114 40 ( ( -LRB- cord-015021-pol2qm74 5115 1 132 132 CD cord-015021-pol2qm74 5115 2 integrins integrin NNS cord-015021-pol2qm74 5115 3 , , , cord-015021-pol2qm74 5115 4 CD18 CD18 NNP cord-015021-pol2qm74 5115 5 ) ) -RRB- cord-015021-pol2qm74 5115 6 on on IN cord-015021-pol2qm74 5115 7 neutrophils neutrophil NNS cord-015021-pol2qm74 5115 8 had have VBD cord-015021-pol2qm74 5115 9 no no DT cord-015021-pol2qm74 5115 10 effect effect NN cord-015021-pol2qm74 5115 11 on on IN cord-015021-pol2qm74 5115 12 the the DT cord-015021-pol2qm74 5115 13 injury injury NN cord-015021-pol2qm74 5115 14 despite despite IN cord-015021-pol2qm74 5115 15 the the DT cord-015021-pol2qm74 5115 16 substantial substantial JJ cord-015021-pol2qm74 5115 17 accumulation accumulation NN cord-015021-pol2qm74 5115 18 of of IN cord-015021-pol2qm74 5115 19 neutrophils neutrophil NNS cord-015021-pol2qm74 5115 20 in in IN cord-015021-pol2qm74 5115 21 the the DT cord-015021-pol2qm74 5115 22 liver liver NN cord-015021-pol2qm74 5115 23 at at IN cord-015021-pol2qm74 5115 24 that that DT cord-015021-pol2qm74 5115 25 time time NN cord-015021-pol2qm74 5115 26 ( ( -LRB- cord-015021-pol2qm74 5115 27 467 467 CD cord-015021-pol2qm74 5115 28 + + SYM cord-015021-pol2qm74 5115 29 52 52 CD cord-015021-pol2qm74 5115 30 PMNs/50 PMNs/50 NNS cord-015021-pol2qm74 5115 31 HPF HPF NNP cord-015021-pol2qm74 5115 32 ; ; : cord-015021-pol2qm74 5115 33 baseline baseline NN cord-015021-pol2qm74 5115 34 : : : cord-015021-pol2qm74 5115 35 13 13 CD cord-015021-pol2qm74 5115 36 + + SYM cord-015021-pol2qm74 5115 37 3 3 CD cord-015021-pol2qm74 5115 38 ) ) -RRB- cord-015021-pol2qm74 5115 39 . . . cord-015021-pol2qm74 5116 1 Isolation isolation NN cord-015021-pol2qm74 5116 2 of of IN cord-015021-pol2qm74 5116 3 KC KC NNP cord-015021-pol2qm74 5116 4 and and CC cord-015021-pol2qm74 5116 5 neutrophils neutrophil NNS cord-015021-pol2qm74 5116 6 from from IN cord-015021-pol2qm74 5116 7 the the DT cord-015021-pol2qm74 5116 8 postischemic postischemic NNP cord-015021-pol2qm74 5116 9 liver liver NN cord-015021-pol2qm74 5116 10 indicated indicate VBD cord-015021-pol2qm74 5116 11 a a DT cord-015021-pol2qm74 5116 12 10-fold 10-fold JJ cord-015021-pol2qm74 5116 13 increase increase NN cord-015021-pol2qm74 5116 14 of of IN cord-015021-pol2qm74 5116 15 the the DT cord-015021-pol2qm74 5116 16 spontaneous spontaneous JJ cord-015021-pol2qm74 5116 17 superoxide superoxide NN cord-015021-pol2qm74 5116 18 formation formation NN cord-015021-pol2qm74 5116 19 only only RB cord-015021-pol2qm74 5116 20 in in IN cord-015021-pol2qm74 5116 21 the the DT cord-015021-pol2qm74 5116 22 KC KC NNP cord-015021-pol2qm74 5116 23 fractions fraction NNS cord-015021-pol2qm74 5116 24 [ [ -LRB- cord-015021-pol2qm74 5116 25 3.85 3.85 CD cord-015021-pol2qm74 5116 26 + + SYM cord-015021-pol2qm74 5116 27 0.68 0.68 CD cord-015021-pol2qm74 5116 28 nmol nmol JJ cord-015021-pol2qm74 5116 29 O2-/h/10%elts O2-/h/10%elts NNP cord-015021-pol2qm74 5116 30 ( ( -LRB- cord-015021-pol2qm74 5116 31 KC2 KC2 NNP cord-015021-pol2qm74 5116 32 ) ) -RRB- cord-015021-pol2qm74 5116 33 ; ; : cord-015021-pol2qm74 5116 34 6.82_+0.92 6.82_+0.92 LS cord-015021-pol2qm74 5116 35 ( ( -LRB- cord-015021-pol2qm74 5116 36 KCa KCa NNS cord-015021-pol2qm74 5116 37 ) ) -RRB- cord-015021-pol2qm74 5116 38 ] ] -RRB- cord-015021-pol2qm74 5116 39 at at IN cord-015021-pol2qm74 5116 40 4h 4h CD cord-015021-pol2qm74 5116 41 RP RP NNP cord-015021-pol2qm74 5116 42 compared compare VBN cord-015021-pol2qm74 5116 43 to to TO cord-015021-pol2qm74 5116 44 control control NN cord-015021-pol2qm74 5116 45 cells cell NNS cord-015021-pol2qm74 5116 46 . . . cord-015021-pol2qm74 5117 1 In in IN cord-015021-pol2qm74 5117 2 addition addition NN cord-015021-pol2qm74 5117 3 , , , cord-015021-pol2qm74 5117 4 stimulation stimulation NN cord-015021-pol2qm74 5117 5 with with IN cord-015021-pol2qm74 5117 6 phorbol phorbol NNP cord-015021-pol2qm74 5117 7 ester ester NNP cord-015021-pol2qm74 5117 8 or or CC cord-015021-pol2qm74 5117 9 opsonized opsonize VBN cord-015021-pol2qm74 5117 10 zymosan zymosan NNP cord-015021-pol2qm74 5117 11 revealed reveal VBD cord-015021-pol2qm74 5117 12 a a DT cord-015021-pol2qm74 5117 13 substantial substantial JJ cord-015021-pol2qm74 5117 14 priming priming NN cord-015021-pol2qm74 5117 15 of of IN cord-015021-pol2qm74 5117 16 KC KC NNP cord-015021-pol2qm74 5117 17 for for IN cord-015021-pol2qm74 5117 18 reactive reactive JJ cord-015021-pol2qm74 5117 19 oxygen oxygen NN cord-015021-pol2qm74 5117 20 formation formation NN cord-015021-pol2qm74 5117 21 . . . cord-015021-pol2qm74 5118 1 In in IN cord-015021-pol2qm74 5118 2 contrast contrast NN cord-015021-pol2qm74 5118 3 to to IN cord-015021-pol2qm74 5118 4 the the DT cord-015021-pol2qm74 5118 5 short short JJ cord-015021-pol2qm74 5118 6 - - HYPH cord-015021-pol2qm74 5118 7 term term NN cord-015021-pol2qm74 5118 8 experiments experiment NNS cord-015021-pol2qm74 5118 9 ( ( -LRB- cord-015021-pol2qm74 5118 10 4h 4h NNP cord-015021-pol2qm74 5118 11 ) ) -RRB- cord-015021-pol2qm74 5118 12 , , , cord-015021-pol2qm74 5118 13 the the DT cord-015021-pol2qm74 5118 14 antibody antibody NN cord-015021-pol2qm74 5118 15 WT3 WT3 NNP cord-015021-pol2qm74 5118 16 ( ( -LRB- cord-015021-pol2qm74 5118 17 4 4 CD cord-015021-pol2qm74 5118 18 mg mg NNP cord-015021-pol2qm74 5118 19 / / SYM cord-015021-pol2qm74 5118 20 kg kg NNP cord-015021-pol2qm74 5118 21 ) ) -RRB- cord-015021-pol2qm74 5118 22 attenuated attenuated JJ cord-015021-pol2qm74 5118 23 liver liver NN cord-015021-pol2qm74 5118 24 injury injury NN cord-015021-pol2qm74 5118 25 by by IN cord-015021-pol2qm74 5118 26 90 90 CD cord-015021-pol2qm74 5118 27 % % NN cord-015021-pol2qm74 5118 28 at at IN cord-015021-pol2qm74 5118 29 24 24 CD cord-015021-pol2qm74 5118 30 h h NN cord-015021-pol2qm74 5118 31 of of IN cord-015021-pol2qm74 5118 32 RP RP NNP cord-015021-pol2qm74 5118 33 and and CC cord-015021-pol2qm74 5118 34 improved improve VBN cord-015021-pol2qm74 5118 35 survival survival NN cord-015021-pol2qm74 5118 36 . . . cord-015021-pol2qm74 5119 1 Conclusion conclusion NN cord-015021-pol2qm74 5119 2 : : : cord-015021-pol2qm74 5120 1 Liver liver NN cord-015021-pol2qm74 5120 2 injury injury NN cord-015021-pol2qm74 5120 3 during during IN cord-015021-pol2qm74 5120 4 the the DT cord-015021-pol2qm74 5120 5 early early JJ cord-015021-pol2qm74 5120 6 RP rp NN cord-015021-pol2qm74 5120 7 phase phase NN cord-015021-pol2qm74 5120 8 is be VBZ cord-015021-pol2qm74 5120 9 mediated mediate VBN cord-015021-pol2qm74 5120 10 mainly mainly RB cord-015021-pol2qm74 5120 11 by by IN cord-015021-pol2qm74 5120 12 KC KC NNP cord-015021-pol2qm74 5120 13 generating generate VBG cord-015021-pol2qm74 5120 14 excessive excessive JJ cord-015021-pol2qm74 5120 15 amounts amount NNS cord-015021-pol2qm74 5120 16 of of IN cord-015021-pol2qm74 5120 17 reactive reactive JJ cord-015021-pol2qm74 5120 18 oxygen oxygen NN cord-015021-pol2qm74 5120 19 while while IN cord-015021-pol2qm74 5120 20 neutrophils neutrophil NNS cord-015021-pol2qm74 5120 21 are be VBP cord-015021-pol2qm74 5120 22 primarily primarily RB cord-015021-pol2qm74 5120 23 responsible responsible JJ cord-015021-pol2qm74 5120 24 for for IN cord-015021-pol2qm74 5120 25 organ organ NN cord-015021-pol2qm74 5120 26 damage damage NN cord-015021-pol2qm74 5120 27 during during IN cord-015021-pol2qm74 5120 28 the the DT cord-015021-pol2qm74 5120 29 later later JJ cord-015021-pol2qm74 5120 30 RP rp NN cord-015021-pol2qm74 5120 31 period period NN cord-015021-pol2qm74 5120 32 . . . cord-015021-pol2qm74 5121 1 ( ( -LRB- cord-015021-pol2qm74 5121 2 ES-06091 es-06091 NN cord-015021-pol2qm74 5121 3 and and CC cord-015021-pol2qm74 5121 4 GM-42957 GM-42957 NNP cord-015021-pol2qm74 5121 5 ) ) -RRB- cord-015021-pol2qm74 5121 6 _SP cord-015021-pol2qm74 5122 1 Tumor tumor NN cord-015021-pol2qm74 5122 2 necrosis necrosis NN cord-015021-pol2qm74 5122 3 factors factor NNS cord-015021-pol2qm74 5122 4 ( ( -LRB- cord-015021-pol2qm74 5122 5 TNF TNF NNP cord-015021-pol2qm74 5122 6 ) ) -RRB- cord-015021-pol2qm74 5122 7 are be VBP cord-015021-pol2qm74 5122 8 cytokines cytokine NNS cord-015021-pol2qm74 5122 9 which which WDT cord-015021-pol2qm74 5122 10 are be VBP cord-015021-pol2qm74 5122 11 cytotoxic cytotoxic JJ cord-015021-pol2qm74 5122 12 towards towards IN cord-015021-pol2qm74 5122 13 some some DT cord-015021-pol2qm74 5122 14 tumors tumor NNS cord-015021-pol2qm74 5122 15 in in IN cord-015021-pol2qm74 5122 16 vivo vivo NN cord-015021-pol2qm74 5122 17 and and CC cord-015021-pol2qm74 5122 18 certain certain JJ cord-015021-pol2qm74 5122 19 tumor tumor NN cord-015021-pol2qm74 5122 20 lines line NNS cord-015021-pol2qm74 5122 21 in in IN cord-015021-pol2qm74 5122 22 vitro vitro FW cord-015021-pol2qm74 5122 23 . . . cord-015021-pol2qm74 5123 1 Moreover moreover RB cord-015021-pol2qm74 5123 2 , , , cord-015021-pol2qm74 5123 3 these these DT cord-015021-pol2qm74 5123 4 polypeptides polypeptide NNS cord-015021-pol2qm74 5123 5 are be VBP cord-015021-pol2qm74 5123 6 powerful powerful JJ cord-015021-pol2qm74 5123 7 immunomodulators immunomodulator NNS cord-015021-pol2qm74 5123 8 and and CC cord-015021-pol2qm74 5123 9 have have VBP cord-015021-pol2qm74 5123 10 been be VBN cord-015021-pol2qm74 5123 11 found find VBN cord-015021-pol2qm74 5123 12 to to TO cord-015021-pol2qm74 5123 13 be be VB cord-015021-pol2qm74 5123 14 distal distal JJ cord-015021-pol2qm74 5123 15 mediators mediator NNS cord-015021-pol2qm74 5123 16 in in IN cord-015021-pol2qm74 5123 17 several several JJ cord-015021-pol2qm74 5123 18 models model NNS cord-015021-pol2qm74 5123 19 of of IN cord-015021-pol2qm74 5123 20 septic septic JJ cord-015021-pol2qm74 5123 21 shock shock NN cord-015021-pol2qm74 5123 22 and and CC cord-015021-pol2qm74 5123 23 septic septic JJ cord-015021-pol2qm74 5123 24 organ organ NN cord-015021-pol2qm74 5123 25 failure failure NN cord-015021-pol2qm74 5123 26 . . . cord-015021-pol2qm74 5124 1 One one CD cord-015021-pol2qm74 5124 2 of of IN cord-015021-pol2qm74 5124 3 the the DT cord-015021-pol2qm74 5124 4 best well RBS cord-015021-pol2qm74 5124 5 - - HYPH cord-015021-pol2qm74 5124 6 characterized characterize VBN cord-015021-pol2qm74 5124 7 experimental experimental JJ cord-015021-pol2qm74 5124 8 systems system NNS cord-015021-pol2qm74 5124 9 is be VBZ cord-015021-pol2qm74 5124 10 the the DT cord-015021-pol2qm74 5124 11 hepatitis hepatitis NN cord-015021-pol2qm74 5124 12 caused cause VBN cord-015021-pol2qm74 5124 13 by by IN cord-015021-pol2qm74 5124 14 LPS LPS NNP cord-015021-pol2qm74 5124 15 or or CC cord-015021-pol2qm74 5124 16 TNF TNF NNP cord-015021-pol2qm74 5124 17 in in IN cord-015021-pol2qm74 5124 18 galactosamine galactosamine NNP cord-015021-pol2qm74 5124 19 ( ( -LRB- cord-015021-pol2qm74 5124 20 GalN)-sensitized galn)-sensitize VBN cord-015021-pol2qm74 5124 21 mice mouse NNS cord-015021-pol2qm74 5124 22 . . . cord-015021-pol2qm74 5125 1 Here here RB cord-015021-pol2qm74 5125 2 we -PRON- PRP cord-015021-pol2qm74 5125 3 describe describe VBP cord-015021-pol2qm74 5125 4 a a DT cord-015021-pol2qm74 5125 5 cell cell NN cord-015021-pol2qm74 5125 6 culture culture NN cord-015021-pol2qm74 5125 7 system system NN cord-015021-pol2qm74 5125 8 , , , cord-015021-pol2qm74 5125 9 in in IN cord-015021-pol2qm74 5125 10 which which WDT cord-015021-pol2qm74 5125 11 the the DT cord-015021-pol2qm74 5125 12 direct direct JJ cord-015021-pol2qm74 5125 13 toxicity toxicity NN cord-015021-pol2qm74 5125 14 of of IN cord-015021-pol2qm74 5125 15 TNF TNF NNP cord-015021-pol2qm74 5125 16 towards towards IN cord-015021-pol2qm74 5125 17 mouse mouse NN cord-015021-pol2qm74 5125 18 hepatocytes hepatocyte NNS cord-015021-pol2qm74 5125 19 was be VBD cord-015021-pol2qm74 5125 20 examined examine VBN cord-015021-pol2qm74 5125 21 . . . cord-015021-pol2qm74 5126 1 The the DT cord-015021-pol2qm74 5126 2 toxicity toxicity NN cord-015021-pol2qm74 5126 3 of of IN cord-015021-pol2qm74 5126 4 TNF TNF NNP cord-015021-pol2qm74 5126 5 , , , cord-015021-pol2qm74 5126 6 as as IN cord-015021-pol2qm74 5126 7 determined determine VBN cord-015021-pol2qm74 5126 8 by by IN cord-015021-pol2qm74 5126 9 LDH LDH NNP cord-015021-pol2qm74 5126 10 - - HYPH cord-015021-pol2qm74 5126 11 release release NN cord-015021-pol2qm74 5126 12 or or CC cord-015021-pol2qm74 5126 13 formazan formazan NN cord-015021-pol2qm74 5126 14 - - NN cord-015021-pol2qm74 5126 15 formation formation NN cord-015021-pol2qm74 5126 16 , , , cord-015021-pol2qm74 5126 17 was be VBD cord-015021-pol2qm74 5126 18 dose dose NN cord-015021-pol2qm74 5126 19 - - HYPH cord-015021-pol2qm74 5126 20 and and CC cord-015021-pol2qm74 5126 21 time time NN cord-015021-pol2qm74 5126 22 - - HYPH cord-015021-pol2qm74 5126 23 dependent dependent JJ cord-015021-pol2qm74 5126 24 . . . cord-015021-pol2qm74 5127 1 The the DT cord-015021-pol2qm74 5127 2 threshold threshold NN cord-015021-pol2qm74 5127 3 of of IN cord-015021-pol2qm74 5127 4 toxicity toxicity NN cord-015021-pol2qm74 5127 5 was be VBD cord-015021-pol2qm74 5127 6 10 10 CD cord-015021-pol2qm74 5127 7 ng ng NN cord-015021-pol2qm74 5127 8 / / SYM cord-015021-pol2qm74 5127 9 ml ml NN cord-015021-pol2qm74 5127 10 , , , cord-015021-pol2qm74 5127 11 which which WDT cord-015021-pol2qm74 5127 12 corresponds correspond VBZ cord-015021-pol2qm74 5127 13 to to IN cord-015021-pol2qm74 5127 14 serum serum NN cord-015021-pol2qm74 5127 15 concentrations concentration NNS cord-015021-pol2qm74 5127 16 found find VBN cord-015021-pol2qm74 5127 17 in in IN cord-015021-pol2qm74 5127 18 mice mouse NNS cord-015021-pol2qm74 5127 19 after after IN cord-015021-pol2qm74 5127 20 LPSinjection lpsinjection NN cord-015021-pol2qm74 5127 21 . . . cord-015021-pol2qm74 5128 1 Toxicity toxicity NN cord-015021-pol2qm74 5128 2 was be VBD cord-015021-pol2qm74 5128 3 only only RB cord-015021-pol2qm74 5128 4 observed observe VBN cord-015021-pol2qm74 5128 5 in in IN cord-015021-pol2qm74 5128 6 hepatocytes hepatocyte NNS cord-015021-pol2qm74 5128 7 sensitized sensitize VBN cord-015021-pol2qm74 5128 8 with with IN cord-015021-pol2qm74 5128 9 transcriptional transcriptional JJ cord-015021-pol2qm74 5128 10 inhibiters inhibiter NNS cord-015021-pol2qm74 5128 11 such such JJ cord-015021-pol2qm74 5128 12 as as IN cord-015021-pol2qm74 5128 13 GalN GalN NNP cord-015021-pol2qm74 5128 14 , , , cord-015021-pol2qm74 5128 15 actinomycin actinomycin NNS cord-015021-pol2qm74 5128 16 D D NNP cord-015021-pol2qm74 5128 17 ( ( -LRB- cord-015021-pol2qm74 5128 18 ActD ActD NNP cord-015021-pol2qm74 5128 19 ) ) -RRB- cord-015021-pol2qm74 5128 20 or or CC cord-015021-pol2qm74 5128 21 cxamanitin cxamanitin NNP cord-015021-pol2qm74 5128 22 . . . cord-015021-pol2qm74 5129 1 Sensitization sensitization NN cord-015021-pol2qm74 5129 2 was be VBD cord-015021-pol2qm74 5129 3 neither neither CC cord-015021-pol2qm74 5129 4 observed observe VBN cord-015021-pol2qm74 5129 5 with with IN cord-015021-pol2qm74 5129 6 different different JJ cord-015021-pol2qm74 5129 7 translational translational JJ cord-015021-pol2qm74 5129 8 inhibitors inhibitor NNS cord-015021-pol2qm74 5129 9 nor nor CC cord-015021-pol2qm74 5129 10 with with IN cord-015021-pol2qm74 5129 11 various various JJ cord-015021-pol2qm74 5129 12 other other JJ cord-015021-pol2qm74 5129 13 metabolic metabolic JJ cord-015021-pol2qm74 5129 14 inlaibitors inlaibitor NNS cord-015021-pol2qm74 5129 15 or or CC cord-015021-pol2qm74 5129 16 toxins toxin NNS cord-015021-pol2qm74 5129 17 . . . cord-015021-pol2qm74 5130 1 Inhibitors inhibitor NNS cord-015021-pol2qm74 5130 2 of of IN cord-015021-pol2qm74 5130 3 protein protein NN cord-015021-pol2qm74 5130 4 synthesis synthesis NN cord-015021-pol2qm74 5130 5 or or CC cord-015021-pol2qm74 5130 6 protein protein NN cord-015021-pol2qm74 5130 7 processing processing NN cord-015021-pol2qm74 5130 8 such such JJ cord-015021-pol2qm74 5130 9 as as IN cord-015021-pol2qm74 5130 10 cycloheximide cycloheximide NN cord-015021-pol2qm74 5130 11 , , , cord-015021-pol2qm74 5130 12 puromycin puromycin NNS cord-015021-pol2qm74 5130 13 , , , cord-015021-pol2qm74 5130 14 tunicamycin tunicamycin NNS cord-015021-pol2qm74 5130 15 and and CC cord-015021-pol2qm74 5130 16 ricin ricin NN cord-015021-pol2qm74 5130 17 protected protect VBN cord-015021-pol2qm74 5130 18 ActDsensitized ActDsensitized NNP cord-015021-pol2qm74 5130 19 hepatocytes hepatocyte NNS cord-015021-pol2qm74 5130 20 from from IN cord-015021-pol2qm74 5130 21 TNF tnf NN cord-015021-pol2qm74 5130 22 - - HYPH cord-015021-pol2qm74 5130 23 induced induce VBN cord-015021-pol2qm74 5130 24 cytotoxicity cytotoxicity NN cord-015021-pol2qm74 5130 25 . . . cord-015021-pol2qm74 5131 1 TNF TNF NNP cord-015021-pol2qm74 5131 2 induced induce VBD cord-015021-pol2qm74 5131 3 apoptotic apoptotic JJ cord-015021-pol2qm74 5131 4 changes change NNS cord-015021-pol2qm74 5131 5 and and CC cord-015021-pol2qm74 5131 6 DNA dna NN cord-015021-pol2qm74 5131 7 - - HYPH cord-015021-pol2qm74 5131 8 fragmentation fragmentation NN cord-015021-pol2qm74 5131 9 in in IN cord-015021-pol2qm74 5131 10 sensitized sensitized JJ cord-015021-pol2qm74 5131 11 hepatocytes hepatocyte NNS cord-015021-pol2qm74 5131 12 which which WDT cord-015021-pol2qm74 5131 13 is be VBZ cord-015021-pol2qm74 5131 14 in in IN cord-015021-pol2qm74 5131 15 line line NN cord-015021-pol2qm74 5131 16 with with IN cord-015021-pol2qm74 5131 17 the the DT cord-015021-pol2qm74 5131 18 above above JJ cord-015021-pol2qm74 5131 19 findings finding NNS cord-015021-pol2qm74 5131 20 that that IN cord-015021-pol2qm74 5131 21 cell cell NN cord-015021-pol2qm74 5131 22 death death NN cord-015021-pol2qm74 5131 23 is be VBZ cord-015021-pol2qm74 5131 24 dependent dependent JJ cord-015021-pol2qm74 5131 25 on on IN cord-015021-pol2qm74 5131 26 protein protein NN cord-015021-pol2qm74 5131 27 synthesis synthesis NN cord-015021-pol2qm74 5131 28 . . . cord-015021-pol2qm74 5132 1 Thus thus RB cord-015021-pol2qm74 5132 2 TNF TNF NNP cord-015021-pol2qm74 5132 3 may may MD cord-015021-pol2qm74 5132 4 be be VB cord-015021-pol2qm74 5132 5 a a DT cord-015021-pol2qm74 5132 6 trigger trigger NN cord-015021-pol2qm74 5132 7 of of IN cord-015021-pol2qm74 5132 8 programmed programmed JJ cord-015021-pol2qm74 5132 9 cell cell NN cord-015021-pol2qm74 5132 10 death death NN cord-015021-pol2qm74 5132 11 during during IN cord-015021-pol2qm74 5132 12 inflammatory inflammatory JJ cord-015021-pol2qm74 5132 13 organ organ NN cord-015021-pol2qm74 5132 14 damage damage NN cord-015021-pol2qm74 5132 15 . . . cord-015021-pol2qm74 5133 1 With with IN cord-015021-pol2qm74 5133 2 the the DT cord-015021-pol2qm74 5133 3 purpose purpose NN cord-015021-pol2qm74 5133 4 of of IN cord-015021-pol2qm74 5133 5 studying study VBG cord-015021-pol2qm74 5133 6 the the DT cord-015021-pol2qm74 5133 7 role role NN cord-015021-pol2qm74 5133 8 of of IN cord-015021-pol2qm74 5133 9 complement complement JJ cord-015021-pol2qm74 5133 10 activation activation NN cord-015021-pol2qm74 5133 11 in in IN cord-015021-pol2qm74 5133 12 tissue tissue NN cord-015021-pol2qm74 5133 13 injury injury NN cord-015021-pol2qm74 5133 14 after after IN cord-015021-pol2qm74 5133 15 ischaemia ischaemia NN cord-015021-pol2qm74 5133 16 and and CC cord-015021-pol2qm74 5133 17 reperfusion reperfusion NN cord-015021-pol2qm74 5133 18 we -PRON- PRP cord-015021-pol2qm74 5133 19 blocked block VBD cord-015021-pol2qm74 5133 20 the the DT cord-015021-pol2qm74 5133 21 complement complement NN cord-015021-pol2qm74 5133 22 cascade cascade NN cord-015021-pol2qm74 5133 23 in in IN cord-015021-pol2qm74 5133 24 a a DT cord-015021-pol2qm74 5133 25 model model NN cord-015021-pol2qm74 5133 26 of of IN cord-015021-pol2qm74 5133 27 rat rat NN cord-015021-pol2qm74 5133 28 liver liver NN cord-015021-pol2qm74 5133 29 isehaemia isehaemia NN cord-015021-pol2qm74 5133 30 and and CC cord-015021-pol2qm74 5133 31 reperfusion reperfusion NN cord-015021-pol2qm74 5133 32 , , , cord-015021-pol2qm74 5133 33 either either CC cord-015021-pol2qm74 5133 34 by by IN cord-015021-pol2qm74 5133 35 administration administration NN cord-015021-pol2qm74 5133 36 of of IN cord-015021-pol2qm74 5133 37 Soluble Soluble NNP cord-015021-pol2qm74 5133 38 Human Human NNP cord-015021-pol2qm74 5133 39 Complement Complement NNP cord-015021-pol2qm74 5133 40 Receptor Receptor NNP cord-015021-pol2qm74 5133 41 Type Type NNP cord-015021-pol2qm74 5133 42 1 1 CD cord-015021-pol2qm74 5133 43 ( ( -LRB- cord-015021-pol2qm74 5133 44 sCRI scri NN cord-015021-pol2qm74 5133 45 ) ) -RRB- cord-015021-pol2qm74 5133 46 , , , cord-015021-pol2qm74 5133 47 25 25 CD cord-015021-pol2qm74 5133 48 mg mg NNP cord-015021-pol2qm74 5133 49 / / SYM cord-015021-pol2qm74 5133 50 Kg Kg NNP cord-015021-pol2qm74 5133 51 IV IV NNP cord-015021-pol2qm74 5133 52 after after IN cord-015021-pol2qm74 5133 53 vascular vascular JJ cord-015021-pol2qm74 5133 54 occlusion occlusion NN cord-015021-pol2qm74 5133 55 ( ( -LRB- cord-015021-pol2qm74 5133 56 n=8 n=8 NN cord-015021-pol2qm74 5133 57 ) ) -RRB- cord-015021-pol2qm74 5133 58 or or CC cord-015021-pol2qm74 5133 59 by by IN cord-015021-pol2qm74 5133 60 depleting deplete VBG cord-015021-pol2qm74 5133 61 the the DT cord-015021-pol2qm74 5133 62 complement complement NN cord-015021-pol2qm74 5133 63 system system NN cord-015021-pol2qm74 5133 64 using use VBG cord-015021-pol2qm74 5133 65 Cobra Cobra NNP cord-015021-pol2qm74 5133 66 Venom Venom NNP cord-015021-pol2qm74 5133 67 Factor factor NN cord-015021-pol2qm74 5133 68 ( ( -LRB- cord-015021-pol2qm74 5133 69 CVF CVF NNP cord-015021-pol2qm74 5133 70 ) ) -RRB- cord-015021-pol2qm74 5134 1 , , , cord-015021-pol2qm74 5134 2 0.5 0.5 CD cord-015021-pol2qm74 5134 3 mg mg NN cord-015021-pol2qm74 5134 4 IM IM NNP cord-015021-pol2qm74 5134 5 , , , cord-015021-pol2qm74 5134 6 24 24 CD cord-015021-pol2qm74 5134 7 and and CC cord-015021-pol2qm74 5134 8 6 6 CD cord-015021-pol2qm74 5134 9 hours hour NNS cord-015021-pol2qm74 5134 10 before before IN cord-015021-pol2qm74 5134 11 ischaemia ischaemia NN cord-015021-pol2qm74 5134 12 ( ( -LRB- cord-015021-pol2qm74 5134 13 n=10 n=10 NNP cord-015021-pol2qm74 5134 14 ) ) -RRB- cord-015021-pol2qm74 5134 15 . . . cord-015021-pol2qm74 5135 1 Non non JJ cord-015021-pol2qm74 5135 2 - - JJ cord-015021-pol2qm74 5135 3 ischaemic ischaemic JJ cord-015021-pol2qm74 5135 4 rats rat NNS cord-015021-pol2qm74 5135 5 ( ( -LRB- cord-015021-pol2qm74 5135 6 n=8 n=8 NN cord-015021-pol2qm74 5135 7 ) ) -RRB- cord-015021-pol2qm74 5135 8 and and CC cord-015021-pol2qm74 5135 9 ischaemic ischaemic JJ cord-015021-pol2qm74 5135 10 non non JJ cord-015021-pol2qm74 5135 11 - - JJ cord-015021-pol2qm74 5135 12 treated treat VBN cord-015021-pol2qm74 5135 13 rats rat NNS cord-015021-pol2qm74 5135 14 ( ( -LRB- cord-015021-pol2qm74 5135 15 n=15 n=15 NNP cord-015021-pol2qm74 5135 16 ) ) -RRB- cord-015021-pol2qm74 5135 17 were be VBD cord-015021-pol2qm74 5135 18 used use VBN cord-015021-pol2qm74 5135 19 as as IN cord-015021-pol2qm74 5135 20 controls control NNS cord-015021-pol2qm74 5135 21 . . . cord-015021-pol2qm74 5136 1 The the DT cord-015021-pol2qm74 5136 2 experimental experimental JJ cord-015021-pol2qm74 5136 3 procedure procedure NN cord-015021-pol2qm74 5136 4 consists consist VBZ cord-015021-pol2qm74 5136 5 of of IN cord-015021-pol2qm74 5136 6 the the DT cord-015021-pol2qm74 5136 7 temporary temporary JJ cord-015021-pol2qm74 5136 8 interruption interruption NN cord-015021-pol2qm74 5136 9 of of IN cord-015021-pol2qm74 5136 10 arterial arterial JJ cord-015021-pol2qm74 5136 11 and and CC cord-015021-pol2qm74 5136 12 portal portal JJ cord-015021-pol2qm74 5136 13 blood blood NN cord-015021-pol2qm74 5136 14 flow flow NN cord-015021-pol2qm74 5136 15 to to IN cord-015021-pol2qm74 5136 16 the the DT cord-015021-pol2qm74 5136 17 left left JJ cord-015021-pol2qm74 5136 18 lateral lateral JJ cord-015021-pol2qm74 5136 19 and and CC cord-015021-pol2qm74 5136 20 medial medial JJ cord-015021-pol2qm74 5136 21 lobes lobe NNS cord-015021-pol2qm74 5136 22 of of IN cord-015021-pol2qm74 5136 23 the the DT cord-015021-pol2qm74 5136 24 liver liver NN cord-015021-pol2qm74 5136 25 during during IN cord-015021-pol2qm74 5136 26 45 45 CD cord-015021-pol2qm74 5136 27 minutes minute NNS cord-015021-pol2qm74 5136 28 , , , cord-015021-pol2qm74 5136 29 followed follow VBN cord-015021-pol2qm74 5136 30 by by IN cord-015021-pol2qm74 5136 31 reperfusion reperfusion NN cord-015021-pol2qm74 5136 32 , , , cord-015021-pol2qm74 5136 33 recording record VBG cord-015021-pol2qm74 5136 34 the the DT cord-015021-pol2qm74 5136 35 liver liver NN cord-015021-pol2qm74 5136 36 blood blood NN cord-015021-pol2qm74 5136 37 flow flow NN cord-015021-pol2qm74 5136 38 and and CC cord-015021-pol2qm74 5136 39 haemoglobin haemoglobin NN cord-015021-pol2qm74 5136 40 saturation saturation NN cord-015021-pol2qm74 5136 41 with with IN cord-015021-pol2qm74 5136 42 a a DT cord-015021-pol2qm74 5136 43 Laser Laser NNP cord-015021-pol2qm74 5136 44 Doppler Doppler NNP cord-015021-pol2qm74 5136 45 Flowmeter Flowmeter NNP cord-015021-pol2qm74 5136 46 and and CC cord-015021-pol2qm74 5136 47 Photometer Photometer NNP cord-015021-pol2qm74 5136 48 during during IN cord-015021-pol2qm74 5136 49 one one CD cord-015021-pol2qm74 5136 50 hour hour NN cord-015021-pol2qm74 5136 51 after after IN cord-015021-pol2qm74 5136 52 declamping declampe VBG cord-015021-pol2qm74 5136 53 ; ; : cord-015021-pol2qm74 5136 54 ALT alt NN cord-015021-pol2qm74 5136 55 levels level NNS cord-015021-pol2qm74 5136 56 were be VBD cord-015021-pol2qm74 5136 57 assayed assay VBN cord-015021-pol2qm74 5136 58 and and CC cord-015021-pol2qm74 5136 59 immunoperoxidase immunoperoxidase NN cord-015021-pol2qm74 5136 60 stainings staining NNS cord-015021-pol2qm74 5136 61 for for IN cord-015021-pol2qm74 5136 62 C3 C3 NNP cord-015021-pol2qm74 5136 63 and and CC cord-015021-pol2qm74 5136 64 C9 C9 NNP cord-015021-pol2qm74 5136 65 were be VBD cord-015021-pol2qm74 5136 66 performed perform VBN cord-015021-pol2qm74 5136 67 . . . cord-015021-pol2qm74 5137 1 There there EX cord-015021-pol2qm74 5137 2 were be VBD cord-015021-pol2qm74 5137 3 statistically statistically RB cord-015021-pol2qm74 5137 4 significant significant JJ cord-015021-pol2qm74 5137 5 differences difference NNS cord-015021-pol2qm74 5137 6 between between IN cord-015021-pol2qm74 5137 7 the the DT cord-015021-pol2qm74 5137 8 experimental experimental JJ cord-015021-pol2qm74 5137 9 ~roups ~roups NNP cord-015021-pol2qm74 5137 10 and and CC cord-015021-pol2qm74 5137 11 the the DT cord-015021-pol2qm74 5137 12 untreated untreated JJ cord-015021-pol2qm74 5137 13 ischaemic ischaemic JJ cord-015021-pol2qm74 5137 14 control control NN cord-015021-pol2qm74 5137 15 group group NN cord-015021-pol2qm74 5137 16 in in IN cord-015021-pol2qm74 5137 17 terms term NNS cord-015021-pol2qm74 5137 18 of of IN cord-015021-pol2qm74 5137 19 post post JJ cord-015021-pol2qm74 5137 20 - - JJ cord-015021-pol2qm74 5137 21 isehaemic isehaemic JJ cord-015021-pol2qm74 5137 22 blood blood NN cord-015021-pol2qm74 5137 23 flow flow NN cord-015021-pol2qm74 5137 24 ( ( -LRB- cord-015021-pol2qm74 5137 25 p<0.001 p<0.001 JJ cord-015021-pol2qm74 5137 26 ) ) -RRB- cord-015021-pol2qm74 5137 27 and and CC cord-015021-pol2qm74 5137 28 haemoglobin haemoglobin NN cord-015021-pol2qm74 5137 29 saturation saturation NN cord-015021-pol2qm74 5137 30 ( ( -LRB- cord-015021-pol2qm74 5137 31 p<0.001 p<0.001 CD cord-015021-pol2qm74 5137 32 ) ) -RRB- cord-015021-pol2qm74 5137 33 . . . cord-015021-pol2qm74 5138 1 C3 C3 NNP cord-015021-pol2qm74 5138 2 and and CC cord-015021-pol2qm74 5138 3 C9 C9 NNP cord-015021-pol2qm74 5138 4 were be VBD cord-015021-pol2qm74 5138 5 present present JJ cord-015021-pol2qm74 5138 6 in in IN cord-015021-pol2qm74 5138 7 the the DT cord-015021-pol2qm74 5138 8 endothelium endothelium NN cord-015021-pol2qm74 5138 9 of of IN cord-015021-pol2qm74 5138 10 the the DT cord-015021-pol2qm74 5138 11 ischaemic ischaemic NNP cord-015021-pol2qm74 5138 12 control control NN cord-015021-pol2qm74 5138 13 group group NN cord-015021-pol2qm74 5138 14 . . . cord-015021-pol2qm74 5139 1 No no DT cord-015021-pol2qm74 5139 2 deposits deposit NNS cord-015021-pol2qm74 5139 3 of of IN cord-015021-pol2qm74 5139 4 C3 C3 NNP cord-015021-pol2qm74 5139 5 or or CC cord-015021-pol2qm74 5139 6 C9 C9 NNP cord-015021-pol2qm74 5139 7 were be VBD cord-015021-pol2qm74 5139 8 found find VBN cord-015021-pol2qm74 5139 9 in in IN cord-015021-pol2qm74 5139 10 the the DT cord-015021-pol2qm74 5139 11 CVF CVF NNP cord-015021-pol2qm74 5139 12 group group NN cord-015021-pol2qm74 5139 13 . . . cord-015021-pol2qm74 5140 1 Few few JJ cord-015021-pol2qm74 5140 2 C3 c3 NN cord-015021-pol2qm74 5140 3 and and CC cord-015021-pol2qm74 5140 4 no no DT cord-015021-pol2qm74 5140 5 C9 C9 NNP cord-015021-pol2qm74 5140 6 were be VBD cord-015021-pol2qm74 5140 7 found find VBN cord-015021-pol2qm74 5140 8 in in IN cord-015021-pol2qm74 5140 9 sCRI sCRI VBG cord-015021-pol2qm74 5140 10 treated treat VBN cord-015021-pol2qm74 5140 11 rats rat NNS cord-015021-pol2qm74 5140 12 . . . cord-015021-pol2qm74 5141 1 These these DT cord-015021-pol2qm74 5141 2 results result NNS cord-015021-pol2qm74 5141 3 show show VBP cord-015021-pol2qm74 5141 4 that that IN cord-015021-pol2qm74 5141 5 the the DT cord-015021-pol2qm74 5141 6 effect effect NN cord-015021-pol2qm74 5141 7 of of IN cord-015021-pol2qm74 5141 8 reperfusion reperfusion NN cord-015021-pol2qm74 5141 9 injury injury NN cord-015021-pol2qm74 5141 10 in in IN cord-015021-pol2qm74 5141 11 the the DT cord-015021-pol2qm74 5141 12 rat rat NN cord-015021-pol2qm74 5141 13 liver liver NN cord-015021-pol2qm74 5141 14 is be VBZ cord-015021-pol2qm74 5141 15 ameliorated ameliorate VBN cord-015021-pol2qm74 5141 16 either either CC cord-015021-pol2qm74 5141 17 by by IN cord-015021-pol2qm74 5141 18 depleting deplete VBG cord-015021-pol2qm74 5141 19 complement complement NN cord-015021-pol2qm74 5141 20 with with IN cord-015021-pol2qm74 5141 21 CVF CVF NNP cord-015021-pol2qm74 5141 22 or or CC cord-015021-pol2qm74 5141 23 by by IN cord-015021-pol2qm74 5141 24 regulating regulate VBG cord-015021-pol2qm74 5141 25 complement complement NN cord-015021-pol2qm74 5141 26 activation activation NN cord-015021-pol2qm74 5141 27 with with IN cord-015021-pol2qm74 5141 28 sCRI scri NN cord-015021-pol2qm74 5141 29 . . . cord-015021-pol2qm74 5142 1 Hepatic hepatic JJ cord-015021-pol2qm74 5142 2 dysfunction dysfunction NN cord-015021-pol2qm74 5142 3 , , , cord-015021-pol2qm74 5142 4 a a DT cord-015021-pol2qm74 5142 5 major major JJ cord-015021-pol2qm74 5142 6 cause cause NN cord-015021-pol2qm74 5142 7 of of IN cord-015021-pol2qm74 5142 8 mortality mortality NN cord-015021-pol2qm74 5142 9 following follow VBG cord-015021-pol2qm74 5142 10 hemorrhagic hemorrhagic JJ cord-015021-pol2qm74 5142 11 shock shock NN cord-015021-pol2qm74 5142 12 , , , cord-015021-pol2qm74 5142 13 has have VBZ cord-015021-pol2qm74 5142 14 not not RB cord-015021-pol2qm74 5142 15 yet yet RB cord-015021-pol2qm74 5142 16 been be VBN cord-015021-pol2qm74 5142 17 well well RB cord-015021-pol2qm74 5142 18 characterized characterize VBN cord-015021-pol2qm74 5142 19 . . . cord-015021-pol2qm74 5143 1 The the DT cord-015021-pol2qm74 5143 2 present present JJ cord-015021-pol2qm74 5143 3 study study NN cord-015021-pol2qm74 5143 4 was be VBD cord-015021-pol2qm74 5143 5 designed design VBN cord-015021-pol2qm74 5143 6 to to TO cord-015021-pol2qm74 5143 7 assess assess VB cord-015021-pol2qm74 5143 8 the the DT cord-015021-pol2qm74 5143 9 effects effect NNS cord-015021-pol2qm74 5143 10 of of IN cord-015021-pol2qm74 5143 11 liver liver NN cord-015021-pol2qm74 5143 12 blood blood NN cord-015021-pol2qm74 5143 13 flow flow NN cord-015021-pol2qm74 5143 14 and and CC cord-015021-pol2qm74 5143 15 cytokine cytokine NN cord-015021-pol2qm74 5143 16 levels level NNS cord-015021-pol2qm74 5143 17 on on IN cord-015021-pol2qm74 5143 18 hepatic hepatic JJ cord-015021-pol2qm74 5143 19 function function NN cord-015021-pol2qm74 5143 20 following follow VBG cord-015021-pol2qm74 5143 21 resuscitation resuscitation NN cord-015021-pol2qm74 5143 22 from from IN cord-015021-pol2qm74 5143 23 severe severe JJ cord-015021-pol2qm74 5143 24 hemorrhagic hemorrhagic JJ cord-015021-pol2qm74 5143 25 shock shock NN cord-015021-pol2qm74 5143 26 in in IN cord-015021-pol2qm74 5143 27 normal normal JJ cord-015021-pol2qm74 5143 28 and and CC cord-015021-pol2qm74 5143 29 cin cin JJ cord-015021-pol2qm74 5143 30 - - HYPH cord-015021-pol2qm74 5143 31 hotic hotic JJ cord-015021-pol2qm74 5143 32 rats rat NNS cord-015021-pol2qm74 5143 33 . . . cord-015021-pol2qm74 5144 1 METHODS methods NN cord-015021-pol2qm74 5144 2 : : : cord-015021-pol2qm74 5145 1 Aftor Aftor NNP cord-015021-pol2qm74 5145 2 pentobarbltal pentobarbltal JJ cord-015021-pol2qm74 5145 3 anesthesia anesthesia NNP cord-015021-pol2qm74 5145 4 , , , cord-015021-pol2qm74 5145 5 23 23 CD cord-015021-pol2qm74 5145 6 control control NN cord-015021-pol2qm74 5145 7 and and CC cord-015021-pol2qm74 5145 8 38 38 CD cord-015021-pol2qm74 5145 9 cirrhotic cirrhotic JJ cord-015021-pol2qm74 5145 10 Sprague Sprague NNP cord-015021-pol2qm74 5145 11 - - HYPH cord-015021-pol2qm74 5145 12 Dawley Dawley NNP cord-015021-pol2qm74 5145 13 rats rat NNS cord-015021-pol2qm74 5145 14 were be VBD cord-015021-pol2qm74 5145 15 subjected subject VBN cord-015021-pol2qm74 5145 16 to to IN cord-015021-pol2qm74 5145 17 severe severe JJ cord-015021-pol2qm74 5145 18 hemorrhage hemorrhage NN cord-015021-pol2qm74 5145 19 to to TO cord-015021-pol2qm74 5145 20 reduce reduce VB cord-015021-pol2qm74 5145 21 their -PRON- PRP$ cord-015021-pol2qm74 5145 22 systolic systolic JJ cord-015021-pol2qm74 5145 23 blood blood NN cord-015021-pol2qm74 5145 24 pressure pressure NN cord-015021-pol2qm74 5145 25 to to IN cord-015021-pol2qm74 5145 26 50 50 CD cord-015021-pol2qm74 5145 27 + + SYM cord-015021-pol2qm74 5145 28 5 5 CD cord-015021-pol2qm74 5145 29 mm mm NN cord-015021-pol2qm74 5145 30 Hg Hg NNS cord-015021-pol2qm74 5145 31 . . . cord-015021-pol2qm74 5146 1 This this DT cord-015021-pol2qm74 5146 2 level level NN cord-015021-pol2qm74 5146 3 of of IN cord-015021-pol2qm74 5146 4 hypotension hypotension NN cord-015021-pol2qm74 5146 5 was be VBD cord-015021-pol2qm74 5146 6 maintained maintain VBN cord-015021-pol2qm74 5146 7 until until IN cord-015021-pol2qm74 5146 8 the the DT cord-015021-pol2qm74 5146 9 skeletal skeletal JJ cord-015021-pol2qm74 5146 10 muscle muscle NN cord-015021-pol2qm74 5146 11 transmembrane transmembrane NN cord-015021-pol2qm74 5146 12 potential potential NN cord-015021-pol2qm74 5146 13 ( ( -LRB- cord-015021-pol2qm74 5146 14 Era era NN cord-015021-pol2qm74 5146 15 ) ) -RRB- cord-015021-pol2qm74 5146 16 depolarized depolarize VBN cord-015021-pol2qm74 5146 17 by by IN cord-015021-pol2qm74 5146 18 25 25 CD cord-015021-pol2qm74 5146 19 % % NN cord-015021-pol2qm74 5146 20 . . . cord-015021-pol2qm74 5146 21 ; ; : cord-015021-pol2qm74 5146 22 the the DT cord-015021-pol2qm74 5146 23 animals animal NNS cord-015021-pol2qm74 5146 24 were be VBD cord-015021-pol2qm74 5146 25 then then RB cord-015021-pol2qm74 5146 26 resuscitated resuscitate VBN cord-015021-pol2qm74 5146 27 with with IN cord-015021-pol2qm74 5146 28 Ringer Ringer NNP cord-015021-pol2qm74 5146 29 's 's POS cord-015021-pol2qm74 5146 30 Lactate Lactate NNP cord-015021-pol2qm74 5146 31 solution solution NN cord-015021-pol2qm74 5146 32 in in IN cord-015021-pol2qm74 5146 33 three three CD cord-015021-pol2qm74 5146 34 times time NNS cord-015021-pol2qm74 5146 35 the the DT cord-015021-pol2qm74 5146 36 volume volume NN cord-015021-pol2qm74 5146 37 of of IN cord-015021-pol2qm74 5146 38 the the DT cord-015021-pol2qm74 5146 39 shed shed JJ cord-015021-pol2qm74 5146 40 blood blood NN cord-015021-pol2qm74 5146 41 . . . cord-015021-pol2qm74 5147 1 Serial serial JJ cord-015021-pol2qm74 5147 2 blood blood NN cord-015021-pol2qm74 5147 3 samples sample NNS cord-015021-pol2qm74 5147 4 for for IN cord-015021-pol2qm74 5147 5 tumor tumor NN cord-015021-pol2qm74 5147 6 necrosis necrosis NN cord-015021-pol2qm74 5147 7 factor factor NN cord-015021-pol2qm74 5147 8 ( ( -LRB- cord-015021-pol2qm74 5147 9 TNF TNF NNP cord-015021-pol2qm74 5147 10 ) ) -RRB- cord-015021-pol2qm74 5147 11 determination determination NN cord-015021-pol2qm74 5147 12 ( ( -LRB- cord-015021-pol2qm74 5147 13 a a DT cord-015021-pol2qm74 5147 14 modified modify VBN cord-015021-pol2qm74 5147 15 flow flow NN cord-015021-pol2qm74 5147 16 - - HYPH cord-015021-pol2qm74 5147 17 cytomeUic cytomeuic NN cord-015021-pol2qm74 5147 18 WEHI WEHI NNP cord-015021-pol2qm74 5147 19 cell cell NN cord-015021-pol2qm74 5147 20 bioassay bioassay NN cord-015021-pol2qm74 5147 21 ) ) -RRB- cord-015021-pol2qm74 5147 22 were be VBD cord-015021-pol2qm74 5147 23 obtained obtain VBN cord-015021-pol2qm74 5147 24 at at IN cord-015021-pol2qm74 5147 25 baseline baseline NN cord-015021-pol2qm74 5147 26 , , , cord-015021-pol2qm74 5147 27 during during IN cord-015021-pol2qm74 5147 28 hemorrhage hemorrhage NN cord-015021-pol2qm74 5147 29 and and CC cord-015021-pol2qm74 5147 30 following follow VBG cord-015021-pol2qm74 5147 31 resuscitation resuscitation NN cord-015021-pol2qm74 5147 32 . . . cord-015021-pol2qm74 5148 1 Liver liver NN cord-015021-pol2qm74 5148 2 blood blood NN cord-015021-pol2qm74 5148 3 flow flow NN cord-015021-pol2qm74 5148 4 measurements measurement NNS cord-015021-pol2qm74 5148 5 by by IN cord-015021-pol2qm74 5148 6 low low JJ cord-015021-pol2qm74 5148 7 dose dose NN cord-015021-pol2qm74 5148 8 galactose galactose NN cord-015021-pol2qm74 5148 9 clearance clearance NN cord-015021-pol2qm74 5148 10 ( ( -LRB- cord-015021-pol2qm74 5148 11 GLC GLC NNP cord-015021-pol2qm74 5148 12 ) ) -RRB- cord-015021-pol2qm74 5148 13 and and CC cord-015021-pol2qm74 5148 14 functional functional JJ cord-015021-pol2qm74 5148 15 bepatocyte bepatocyte CC cord-015021-pol2qm74 5148 16 mass mass NN cord-015021-pol2qm74 5148 17 ( ( -LRB- cord-015021-pol2qm74 5148 18 FHM FHM NNP cord-015021-pol2qm74 5148 19 ; ; : cord-015021-pol2qm74 5149 1 defared defare VBN cord-015021-pol2qm74 5149 2 as as IN cord-015021-pol2qm74 5149 3 galactose galactose NN cord-015021-pol2qm74 5149 4 elimination elimination NN cord-015021-pol2qm74 5149 5 capacity capacity NN cord-015021-pol2qm74 5149 6 [ [ -LRB- cord-015021-pol2qm74 5149 7 GEC GEC NNP cord-015021-pol2qm74 5149 8 ] ] -RRB- cord-015021-pol2qm74 5149 9 from from IN cord-015021-pol2qm74 5149 10 the the DT cord-015021-pol2qm74 5149 11 zero zero CD cord-015021-pol2qm74 5149 12 order order NN cord-015021-pol2qm74 5149 13 portion portion NN cord-015021-pol2qm74 5149 14 of of IN cord-015021-pol2qm74 5149 15 the the DT cord-015021-pol2qm74 5149 16 plasma plasma NN cord-015021-pol2qm74 5149 17 disappearance disappearance NN cord-015021-pol2qm74 5149 18 curve curve NN cord-015021-pol2qm74 5149 19 following follow VBG cord-015021-pol2qm74 5149 20 an an DT cord-015021-pol2qm74 5149 21 intravenous intravenous JJ cord-015021-pol2qm74 5149 22 galactose galactose NN cord-015021-pol2qm74 5149 23 bolus bolus NN cord-015021-pol2qm74 5149 24 [ [ -LRB- cord-015021-pol2qm74 5149 25 500 500 CD cord-015021-pol2qm74 5149 26 mg mg NNP cord-015021-pol2qm74 5149 27 / / SYM cord-015021-pol2qm74 5149 28 kg kg NNP cord-015021-pol2qm74 5149 29 ] ] -RRB- cord-015021-pol2qm74 5149 30 , , , cord-015021-pol2qm74 5149 31 divided divide VBN cord-015021-pol2qm74 5149 32 by by IN cord-015021-pol2qm74 5149 33 liver liver NN cord-015021-pol2qm74 5149 34 weight weight NN cord-015021-pol2qm74 5149 35 ) ) -RRB- cord-015021-pol2qm74 5149 36 were be VBD cord-015021-pol2qm74 5149 37 measured measure VBN cord-015021-pol2qm74 5149 38 before before IN cord-015021-pol2qm74 5149 39 shock shock NN cord-015021-pol2qm74 5149 40 and and CC cord-015021-pol2qm74 5149 41 after after IN cord-015021-pol2qm74 5149 42 resuscitation resuscitation NN cord-015021-pol2qm74 5149 43 . . . cord-015021-pol2qm74 5150 1 RESULTS result NNS cord-015021-pol2qm74 5150 2 : : : cord-015021-pol2qm74 5151 1 Higher high JJR cord-015021-pol2qm74 5151 2 survival survival NN cord-015021-pol2qm74 5151 3 rates rate NNS cord-015021-pol2qm74 5151 4 ( ( -LRB- cord-015021-pol2qm74 5151 5 p p NN cord-015021-pol2qm74 5151 6 < < XX cord-015021-pol2qm74 5151 7 .05 .05 NFP cord-015021-pol2qm74 5151 8 ) ) -RRB- cord-015021-pol2qm74 5151 9 were be VBD cord-015021-pol2qm74 5151 10 observed observe VBN cord-015021-pol2qm74 5151 11 in in IN cord-015021-pol2qm74 5151 12 control control NN cord-015021-pol2qm74 5151 13 as as IN cord-015021-pol2qm74 5151 14 compared compare VBN cord-015021-pol2qm74 5151 15 with with IN cord-015021-pol2qm74 5151 16 cirrhotic cirrhotic JJ cord-015021-pol2qm74 5151 17 rats rat NNS cord-015021-pol2qm74 5151 18 . . . cord-015021-pol2qm74 5152 1 Shock shock NN cord-015021-pol2qm74 5152 2 produced produce VBD cord-015021-pol2qm74 5152 3 a a DT cord-015021-pol2qm74 5152 4 significant significant JJ cord-015021-pol2qm74 5152 5 reduction reduction NN cord-015021-pol2qm74 5152 6 in in IN cord-015021-pol2qm74 5152 7 GEC GEC NNP cord-015021-pol2qm74 5152 8 ( ( -LRB- cord-015021-pol2qm74 5152 9 to to IN cord-015021-pol2qm74 5152 10 < < XX cord-015021-pol2qm74 5152 11 0.01 0.01 CD cord-015021-pol2qm74 5152 12 ) ) -RRB- cord-015021-pol2qm74 5152 13 ; ; : cord-015021-pol2qm74 5152 14 FHM FHM NNP cord-015021-pol2qm74 5152 15 ( ( -LRB- cord-015021-pol2qm74 5152 16 19 19 CD cord-015021-pol2qm74 5152 17 < < XX cord-015021-pol2qm74 5152 18 .01 .01 NFP cord-015021-pol2qm74 5152 19 ) ) -RRB- cord-015021-pol2qm74 5152 20 ; ; : cord-015021-pol2qm74 5152 21 and and CC cord-015021-pol2qm74 5152 22 liver liver NN cord-015021-pol2qm74 5152 23 blood blood NN cord-015021-pol2qm74 5152 24 flow flow NN cord-015021-pol2qm74 5152 25 ( ( -LRB- cord-015021-pol2qm74 5152 26 p p NN cord-015021-pol2qm74 5152 27 < < XX cord-015021-pol2qm74 5152 28 0.01 0.01 CD cord-015021-pol2qm74 5152 29 ) ) -RRB- cord-015021-pol2qm74 5152 30 in in IN cord-015021-pol2qm74 5152 31 normal normal JJ cord-015021-pol2qm74 5152 32 and and CC cord-015021-pol2qm74 5152 33 cirrhotic cirrhotic JJ cord-015021-pol2qm74 5152 34 rats rat NNS cord-015021-pol2qm74 5152 35 . . . cord-015021-pol2qm74 5153 1 Decreases decrease NNS cord-015021-pol2qm74 5153 2 in in IN cord-015021-pol2qm74 5153 3 GEC GEC NNP cord-015021-pol2qm74 5153 4 and and CC cord-015021-pol2qm74 5153 5 FI FI NNP cord-015021-pol2qm74 5153 6 - - HYPH cord-015021-pol2qm74 5153 7 IM IM NNP cord-015021-pol2qm74 5153 8 were be VBD cord-015021-pol2qm74 5153 9 greater great JJR cord-015021-pol2qm74 5153 10 ( ( -LRB- cord-015021-pol2qm74 5153 11 p p NN cord-015021-pol2qm74 5153 12 < < XX cord-015021-pol2qm74 5153 13 0.05 0.05 CD cord-015021-pol2qm74 5153 14 ) ) -RRB- cord-015021-pol2qm74 5153 15 in in IN cord-015021-pol2qm74 5153 16 cirrhotic cirrhotic JJ cord-015021-pol2qm74 5153 17 rots rot NNS cord-015021-pol2qm74 5153 18 . . . cord-015021-pol2qm74 5154 1 TNF TNF NNP cord-015021-pol2qm74 5154 2 levels level NNS cord-015021-pol2qm74 5154 3 were be VBD cord-015021-pol2qm74 5154 4 higher high JJR cord-015021-pol2qm74 5154 5 ( ( -LRB- cord-015021-pol2qm74 5154 6 p p NN cord-015021-pol2qm74 5154 7 < < XX cord-015021-pol2qm74 5154 8 0.05 0.05 CD cord-015021-pol2qm74 5154 9 ) ) -RRB- cord-015021-pol2qm74 5154 10 in in IN cord-015021-pol2qm74 5154 11 cirrhotic cirrhotic JJ cord-015021-pol2qm74 5154 12 rats rat NNS cord-015021-pol2qm74 5154 13 at at IN cord-015021-pol2qm74 5154 14 baseline baseline NN cord-015021-pol2qm74 5154 15 and and CC cord-015021-pol2qm74 5154 16 during during IN cord-015021-pol2qm74 5154 17 induction induction NN cord-015021-pol2qm74 5154 18 of of IN cord-015021-pol2qm74 5154 19 shock shock NN cord-015021-pol2qm74 5154 20 . . . cord-015021-pol2qm74 5155 1 Pre pre JJ cord-015021-pol2qm74 5155 2 Gap Gap NNP cord-015021-pol2qm74 5155 3 junctions junction NNS cord-015021-pol2qm74 5155 4 provide provide VBP cord-015021-pol2qm74 5155 5 pathways pathway NNS cord-015021-pol2qm74 5155 6 for for IN cord-015021-pol2qm74 5155 7 metabolic metabolic JJ cord-015021-pol2qm74 5155 8 signals signal NNS cord-015021-pol2qm74 5155 9 between between IN cord-015021-pol2qm74 5155 10 cells cell NNS cord-015021-pol2qm74 5155 11 . . . cord-015021-pol2qm74 5156 1 In in IN cord-015021-pol2qm74 5156 2 the the DT cord-015021-pol2qm74 5156 3 liver liver NN cord-015021-pol2qm74 5156 4 , , , cord-015021-pol2qm74 5156 5 the the DT cord-015021-pol2qm74 5156 6 majority majority NN cord-015021-pol2qm74 5156 7 of of IN cord-015021-pol2qm74 5156 8 gap gap NN cord-015021-pol2qm74 5156 9 junctions junction NNS cord-015021-pol2qm74 5156 10 are be VBP cord-015021-pol2qm74 5156 11 composed compose VBN cord-015021-pol2qm74 5156 12 of of IN cord-015021-pol2qm74 5156 13 connexin connexin NNP cord-015021-pol2qm74 5156 14 32 32 CD cord-015021-pol2qm74 5156 15 ( ( -LRB- cord-015021-pol2qm74 5156 16 Cx32 Cx32 NNP cord-015021-pol2qm74 5156 17 ) ) -RRB- cord-015021-pol2qm74 5156 18 polypeptide polypeptide NN cord-015021-pol2qm74 5156 19 subunits subunit NNS cord-015021-pol2qm74 5156 20 , , , cord-015021-pol2qm74 5156 21 and and CC cord-015021-pol2qm74 5156 22 are be VBP cord-015021-pol2qm74 5156 23 regulated regulate VBN cord-015021-pol2qm74 5156 24 by by IN cord-015021-pol2qm74 5156 25 gluconeogenic gluconeogenic JJ cord-015021-pol2qm74 5156 26 hormones hormone NNS cord-015021-pol2qm74 5156 27 . . . cord-015021-pol2qm74 5157 1 Since since IN cord-015021-pol2qm74 5157 2 sepsis sepsis NN cord-015021-pol2qm74 5157 3 and and CC cord-015021-pol2qm74 5157 4 other other JJ cord-015021-pol2qm74 5157 5 inflammatory inflammatory JJ cord-015021-pol2qm74 5157 6 states state NNS cord-015021-pol2qm74 5157 7 alter alter VBP cord-015021-pol2qm74 5157 8 hepatic hepatic JJ cord-015021-pol2qm74 5157 9 glucoregulatory glucoregulatory NN cord-015021-pol2qm74 5157 10 control control NN cord-015021-pol2qm74 5157 11 , , , cord-015021-pol2qm74 5157 12 we -PRON- PRP cord-015021-pol2qm74 5157 13 have have VBP cord-015021-pol2qm74 5157 14 evaluated evaluate VBN cord-015021-pol2qm74 5157 15 the the DT cord-015021-pol2qm74 5157 16 contribution contribution NN cord-015021-pol2qm74 5157 17 of of IN cord-015021-pol2qm74 5157 18 gap gap NN cord-015021-pol2qm74 5157 19 junctional junctional JJ cord-015021-pol2qm74 5157 20 conductance conductance NN cord-015021-pol2qm74 5157 21 to to IN cord-015021-pol2qm74 5157 22 the the DT cord-015021-pol2qm74 5157 23 metabolic metabolic JJ cord-015021-pol2qm74 5157 24 dysregulation dysregulation NN cord-015021-pol2qm74 5157 25 in in IN cord-015021-pol2qm74 5157 26 the the DT cord-015021-pol2qm74 5157 27 liver liver NN cord-015021-pol2qm74 5157 28 . . . cord-015021-pol2qm74 5158 1 An an DT cord-015021-pol2qm74 5158 2 acute acute JJ cord-015021-pol2qm74 5158 3 inflammation inflammation NN cord-015021-pol2qm74 5158 4 was be VBD cord-015021-pol2qm74 5158 5 induced induce VBN cord-015021-pol2qm74 5158 6 in in IN cord-015021-pol2qm74 5158 7 rats rat NNS cord-015021-pol2qm74 5158 8 by by IN cord-015021-pol2qm74 5158 9 injection injection NN cord-015021-pol2qm74 5158 10 with with IN cord-015021-pol2qm74 5158 11 E. E. NNP cord-015021-pol2qm74 5158 12 coli coli NNS cord-015021-pol2qm74 5158 13 endotoxin endotoxin NN cord-015021-pol2qm74 5159 1 ( ( -LRB- cord-015021-pol2qm74 5159 2 LPS LPS NNP cord-015021-pol2qm74 5159 3 lmg lmg NNP cord-015021-pol2qm74 5159 4 / / SYM cord-015021-pol2qm74 5159 5 kg kg NNP cord-015021-pol2qm74 5159 6 ) ) -RRB- cord-015021-pol2qm74 5159 7 . . . cord-015021-pol2qm74 5160 1 Northern northern JJ cord-015021-pol2qm74 5160 2 blot blot NN cord-015021-pol2qm74 5160 3 / / SYM cord-015021-pol2qm74 5160 4 hybridization hybridization NN cord-015021-pol2qm74 5160 5 analysis analysis NN cord-015021-pol2qm74 5160 6 of of IN cord-015021-pol2qm74 5160 7 total total JJ cord-015021-pol2qm74 5160 8 RNA RNA NNP cord-015021-pol2qm74 5160 9 isolated isolate VBN cord-015021-pol2qm74 5160 10 from from IN cord-015021-pol2qm74 5160 11 livers liver NNS cord-015021-pol2qm74 5160 12 after after IN cord-015021-pol2qm74 5160 13 endotoxin endotoxin NN cord-015021-pol2qm74 5160 14 injection injection NN cord-015021-pol2qm74 5160 15 show show VBP cord-015021-pol2qm74 5160 16 a a DT cord-015021-pol2qm74 5160 17 decrease decrease NN cord-015021-pol2qm74 5160 18 in in IN cord-015021-pol2qm74 5160 19 the the DT cord-015021-pol2qm74 5160 20 steady steady JJ cord-015021-pol2qm74 5160 21 state state NN cord-015021-pol2qm74 5160 22 transcript transcript NN cord-015021-pol2qm74 5160 23 levels level NNS cord-015021-pol2qm74 5160 24 of of IN cord-015021-pol2qm74 5160 25 Cx32 Cx32 NNPS cord-015021-pol2qm74 5160 26 to to IN cord-015021-pol2qm74 5160 27 18 18 CD cord-015021-pol2qm74 5160 28 % % NN cord-015021-pol2qm74 5160 29 of of IN cord-015021-pol2qm74 5160 30 sham sham JJ cord-015021-pol2qm74 5160 31 controls control NNS cord-015021-pol2qm74 5160 32 . . . cord-015021-pol2qm74 5161 1 Immunostaining immunostaine VBG cord-015021-pol2qm74 5161 2 of of IN cord-015021-pol2qm74 5161 3 liver liver NN cord-015021-pol2qm74 5161 4 sections section NNS cord-015021-pol2qm74 5161 5 using use VBG cord-015021-pol2qm74 5161 6 anti anti JJ cord-015021-pol2qm74 5161 7 - - NNP cord-015021-pol2qm74 5161 8 Cx32 Cx32 NNP cord-015021-pol2qm74 5161 9 revealed reveal VBD cord-015021-pol2qm74 5161 10 punctate punctate NN cord-015021-pol2qm74 5161 11 fluorescent fluorescent NN cord-015021-pol2qm74 5161 12 staining stain VBG cord-015021-pol2qm74 5161 13 on on IN cord-015021-pol2qm74 5161 14 the the DT cord-015021-pol2qm74 5161 15 plasma plasma NN cord-015021-pol2qm74 5161 16 membrane membrane NN cord-015021-pol2qm74 5161 17 at at IN cord-015021-pol2qm74 5161 18 regions region NNS cord-015021-pol2qm74 5161 19 of of IN cord-015021-pol2qm74 5161 20 call call NN cord-015021-pol2qm74 5161 21 - - HYPH cord-015021-pol2qm74 5161 22 cell cell NN cord-015021-pol2qm74 5161 23 contact contact NN cord-015021-pol2qm74 5161 24 in in IN cord-015021-pol2qm74 5161 25 saline saline NN cord-015021-pol2qm74 5161 26 injected inject VBN cord-015021-pol2qm74 5161 27 animals animal NNS cord-015021-pol2qm74 5161 28 , , , cord-015021-pol2qm74 5161 29 whereas whereas RB cord-015021-pol2qm74 5161 30 , , , cord-015021-pol2qm74 5161 31 staining staining NN cord-015021-pol2qm74 5161 32 was be VBD cord-015021-pol2qm74 5161 33 only only RB cord-015021-pol2qm74 5161 34 observed observe VBN cord-015021-pol2qm74 5161 35 in in IN cord-015021-pol2qm74 5161 36 cytoplasmic cytoplasmic JJ cord-015021-pol2qm74 5161 37 vesicles vesicle NNS cord-015021-pol2qm74 5161 38 6 6 CD cord-015021-pol2qm74 5161 39 hrs hrs NN cord-015021-pol2qm74 5161 40 after after IN cord-015021-pol2qm74 5161 41 animals animal NNS cord-015021-pol2qm74 5161 42 were be VBD cord-015021-pol2qm74 5161 43 treated treat VBN cord-015021-pol2qm74 5161 44 with with IN cord-015021-pol2qm74 5161 45 LPS LPS NNP cord-015021-pol2qm74 5161 46 , , , cord-015021-pol2qm74 5161 47 suggesting suggest VBG cord-015021-pol2qm74 5161 48 the the DT cord-015021-pol2qm74 5161 49 internalization internalization NN cord-015021-pol2qm74 5161 50 of of IN cord-015021-pol2qm74 5161 51 Cx32 Cx32 NNPS cord-015021-pol2qm74 5161 52 without without IN cord-015021-pol2qm74 5161 53 replacement replacement NN cord-015021-pol2qm74 5161 54 on on IN cord-015021-pol2qm74 5161 55 the the DT cord-015021-pol2qm74 5161 56 cell cell NN cord-015021-pol2qm74 5161 57 surface surface NN cord-015021-pol2qm74 5161 58 . . . cord-015021-pol2qm74 5162 1 The the DT cord-015021-pol2qm74 5162 2 staining staining NN cord-015021-pol2qm74 5162 3 was be VBD cord-015021-pol2qm74 5162 4 quantitated quantitate VBN cord-015021-pol2qm74 5162 5 and and CC cord-015021-pol2qm74 5162 6 expressed express VBD cord-015021-pol2qm74 5162 7 as as IN cord-015021-pol2qm74 5162 8 % % NN cord-015021-pol2qm74 5162 9 of of IN cord-015021-pol2qm74 5162 10 pixels pixel NNS cord-015021-pol2qm74 5162 11 above above IN cord-015021-pol2qm74 5162 12 threshold threshold NN cord-015021-pol2qm74 5162 13 . . . cord-015021-pol2qm74 5163 1 At at IN cord-015021-pol2qm74 5163 2 6hr 6hr NNP cord-015021-pol2qm74 5163 3 post post NN cord-015021-pol2qm74 5163 4 injection injection NN cord-015021-pol2qm74 5163 5 3.6 3.6 CD cord-015021-pol2qm74 5163 6 % % NN cord-015021-pol2qm74 5163 7 ofpixels ofpixel NNS cord-015021-pol2qm74 5163 8 exceeded exceed VBD cord-015021-pol2qm74 5163 9 threshold threshold NN cord-015021-pol2qm74 5163 10 , , , cord-015021-pol2qm74 5163 11 compared compare VBN cord-015021-pol2qm74 5163 12 to to IN cord-015021-pol2qm74 5163 13 16.2 16.2 CD cord-015021-pol2qm74 5163 14 % % NN cord-015021-pol2qm74 5163 15 in in IN cord-015021-pol2qm74 5163 16 sham sham NN cord-015021-pol2qm74 5163 17 controls control NNS cord-015021-pol2qm74 5163 18 . . . cord-015021-pol2qm74 5164 1 Functional functional JJ cord-015021-pol2qm74 5164 2 gap gap NN cord-015021-pol2qm74 5164 3 junctional junctional JJ cord-015021-pol2qm74 5164 4 communication communication NN cord-015021-pol2qm74 5164 5 was be VBD cord-015021-pol2qm74 5164 6 assessed assess VBN cord-015021-pol2qm74 5164 7 by by IN cord-015021-pol2qm74 5164 8 dye dye NN cord-015021-pol2qm74 5164 9 coupling coupling NN cord-015021-pol2qm74 5164 10 using use VBG cord-015021-pol2qm74 5164 11 lucifer lucifer NNP cord-015021-pol2qm74 5164 12 yellow yellow NNP cord-015021-pol2qm74 5164 13 in in IN cord-015021-pol2qm74 5164 14 an an DT cord-015021-pol2qm74 5164 15 isolated isolated JJ cord-015021-pol2qm74 5164 16 perfused perfuse VBN cord-015021-pol2qm74 5164 17 liver liver NN cord-015021-pol2qm74 5164 18 under under IN cord-015021-pol2qm74 5164 19 intravital intravital JJ cord-015021-pol2qm74 5164 20 fluorescence fluorescence NN cord-015021-pol2qm74 5164 21 microscopy microscopy NN cord-015021-pol2qm74 5164 22 . . . cord-015021-pol2qm74 5165 1 Dye dye NN cord-015021-pol2qm74 5165 2 diffusion diffusion NN cord-015021-pol2qm74 5165 3 was be VBD cord-015021-pol2qm74 5165 4 markedly markedly RB cord-015021-pol2qm74 5165 5 decreased decrease VBN cord-015021-pol2qm74 5165 6 6hr 6hr NN cord-015021-pol2qm74 5165 7 after after IN cord-015021-pol2qm74 5165 8 endotoxin endotoxin NN cord-015021-pol2qm74 5165 9 injection injection NN cord-015021-pol2qm74 5165 10 . . . cord-015021-pol2qm74 5166 1 This this DT cord-015021-pol2qm74 5166 2 suggests suggest VBZ cord-015021-pol2qm74 5166 3 that that IN cord-015021-pol2qm74 5166 4 decreased decrease VBD cord-015021-pol2qm74 5166 5 metabolic metabolic JJ cord-015021-pol2qm74 5166 6 coupling coupling NN cord-015021-pol2qm74 5166 7 after after IN cord-015021-pol2qm74 5166 8 LPS LPS NNP cord-015021-pol2qm74 5166 9 injection injection NN cord-015021-pol2qm74 5166 10 results result NNS cord-015021-pol2qm74 5166 11 from from IN cord-015021-pol2qm74 5166 12 decreased decrease VBD cord-015021-pol2qm74 5166 13 gap gap NN cord-015021-pol2qm74 5166 14 junction junction NN cord-015021-pol2qm74 5166 15 abundance abundance NN cord-015021-pol2qm74 5166 16 . . . cord-015021-pol2qm74 5167 1 The the DT cord-015021-pol2qm74 5167 2 present present JJ cord-015021-pol2qm74 5167 3 data datum NNS cord-015021-pol2qm74 5167 4 suggest suggest VBP cord-015021-pol2qm74 5167 5 that that IN cord-015021-pol2qm74 5167 6 metabolic metabolic JJ cord-015021-pol2qm74 5167 7 dysregulation dysregulation NN cord-015021-pol2qm74 5167 8 during during IN cord-015021-pol2qm74 5167 9 sepsis sepsis NN cord-015021-pol2qm74 5167 10 may may MD cord-015021-pol2qm74 5167 11 arise arise VB cord-015021-pol2qm74 5167 12 in in IN cord-015021-pol2qm74 5167 13 part part NN cord-015021-pol2qm74 5167 14 from from IN cord-015021-pol2qm74 5167 15 changes change NNS cord-015021-pol2qm74 5167 16 in in IN cord-015021-pol2qm74 5167 17 intercellular intercellular JJ cord-015021-pol2qm74 5167 18 communication communication NN cord-015021-pol2qm74 5167 19 caused cause VBN cord-015021-pol2qm74 5167 20 by by IN cord-015021-pol2qm74 5167 21 a a DT cord-015021-pol2qm74 5167 22 decrease decrease NN cord-015021-pol2qm74 5167 23 in in IN cord-015021-pol2qm74 5167 24 gap gap NN cord-015021-pol2qm74 5167 25 junctional junctional JJ cord-015021-pol2qm74 5167 26 expression expression NN cord-015021-pol2qm74 5167 27 and and CC cord-015021-pol2qm74 5167 28 communication communication NN cord-015021-pol2qm74 5167 29 . . . cord-015021-pol2qm74 5168 1 Given give VBN cord-015021-pol2qm74 5168 2 the the DT cord-015021-pol2qm74 5168 3 marked marked JJ cord-015021-pol2qm74 5168 4 metabolic metabolic JJ cord-015021-pol2qm74 5168 5 heterogeneity heterogeneity NN cord-015021-pol2qm74 5168 6 of of IN cord-015021-pol2qm74 5168 7 hepatocytes hepatocyte NNS cord-015021-pol2qm74 5168 8 with with IN cord-015021-pol2qm74 5168 9 respect respect NN cord-015021-pol2qm74 5168 10 to to IN cord-015021-pol2qm74 5168 11 acinar acinar JJ cord-015021-pol2qm74 5168 12 location location NN cord-015021-pol2qm74 5168 13 , , , cord-015021-pol2qm74 5168 14 metabolic metabolic JJ cord-015021-pol2qm74 5168 15 signaling signaling NN cord-015021-pol2qm74 5168 16 via via IN cord-015021-pol2qm74 5168 17 gap gap NN cord-015021-pol2qm74 5168 18 junctions junction NNS cord-015021-pol2qm74 5168 19 most most RBS cord-015021-pol2qm74 5168 20 likely likely RB cord-015021-pol2qm74 5168 21 serves serve VBZ cord-015021-pol2qm74 5168 22 to to TO cord-015021-pol2qm74 5168 23 moderate moderate VB cord-015021-pol2qm74 5168 24 this this DT cord-015021-pol2qm74 5168 25 heterogeneity heterogeneity NN cord-015021-pol2qm74 5168 26 , , , cord-015021-pol2qm74 5168 27 contributing contribute VBG cord-015021-pol2qm74 5168 28 to to IN cord-015021-pol2qm74 5168 29 a a DT cord-015021-pol2qm74 5168 30 coordinated coordinated JJ cord-015021-pol2qm74 5168 31 metabolic metabolic JJ cord-015021-pol2qm74 5168 32 response response NN cord-015021-pol2qm74 5168 33 . . . cord-015021-pol2qm74 5169 1 Altered alter VBN cord-015021-pol2qm74 5169 2 cellular cellular JJ cord-015021-pol2qm74 5169 3 Ca Ca NNP cord-015021-pol2qm74 5169 4 2÷ 2÷ CD cord-015021-pol2qm74 5169 5 regulation regulation NN cord-015021-pol2qm74 5169 6 might may MD cord-015021-pol2qm74 5169 7 be be VB cord-015021-pol2qm74 5169 8 a a DT cord-015021-pol2qm74 5169 9 critical critical JJ cord-015021-pol2qm74 5169 10 step step NN cord-015021-pol2qm74 5169 11 in in IN cord-015021-pol2qm74 5169 12 organ organ NN cord-015021-pol2qm74 5169 13 dysfunction dysfunction NN cord-015021-pol2qm74 5169 14 during during IN cord-015021-pol2qm74 5169 15 sepsis sepsis NN cord-015021-pol2qm74 5169 16 and and CC cord-015021-pol2qm74 5169 17 ischemia ischemia NN cord-015021-pol2qm74 5169 18 / / SYM cord-015021-pol2qm74 5169 19 reperfusion reperfusion NN cord-015021-pol2qm74 5169 20 events event NNS cord-015021-pol2qm74 5169 21 . . . cord-015021-pol2qm74 5170 1 The the DT cord-015021-pol2qm74 5170 2 aim aim NN cord-015021-pol2qm74 5170 3 of of IN cord-015021-pol2qm74 5170 4 the the DT cord-015021-pol2qm74 5170 5 present present JJ cord-015021-pol2qm74 5170 6 study study NN cord-015021-pol2qm74 5170 7 was be VBD cord-015021-pol2qm74 5170 8 to to TO cord-015021-pol2qm74 5170 9 evaluate evaluate VB cord-015021-pol2qm74 5170 10 hepato hepato NNP cord-015021-pol2qm74 5170 11 - - HYPH cord-015021-pol2qm74 5170 12 ceUular ceUular NNP cord-015021-pol2qm74 5171 1 Ca ca RB cord-015021-pol2qm74 5171 2 2÷ 2÷ CD cord-015021-pol2qm74 5171 3 regulation regulation NN cord-015021-pol2qm74 5171 4 in in IN cord-015021-pol2qm74 5171 5 isehemiah'eperfusion isehemiah'eperfusion NNP cord-015021-pol2qm74 5171 6 after after IN cord-015021-pol2qm74 5171 7 hemorrhage hemorrhage NN cord-015021-pol2qm74 5171 8 and and CC cord-015021-pol2qm74 5171 9 to to TO cord-015021-pol2qm74 5171 10 assess assess VB cord-015021-pol2qm74 5171 11 effectiveness effectiveness NN cord-015021-pol2qm74 5171 12 of of IN cord-015021-pol2qm74 5171 13 TNFc~-monoclonal TNFc~-monoclonal NNP cord-015021-pol2qm74 5171 14 antibody antibody NN cord-015021-pol2qm74 5171 15 ( ( -LRB- cord-015021-pol2qm74 5171 16 TNFo~-MoAB TNFo~-MoAB NNP cord-015021-pol2qm74 5171 17 ) ) -RRB- cord-015021-pol2qm74 5171 18 . . . cord-015021-pol2qm74 5172 1 Methods method NNS cord-015021-pol2qm74 5172 2 . . . cord-015021-pol2qm74 5173 1 Male Male NNP cord-015021-pol2qm74 5173 2 Sprague Sprague NNP cord-015021-pol2qm74 5173 3 - - HYPH cord-015021-pol2qm74 5173 4 Dawley Dawley NNP cord-015021-pol2qm74 5173 5 rats rat NNS cord-015021-pol2qm74 5173 6 ( ( -LRB- cord-015021-pol2qm74 5173 7 250 250 CD cord-015021-pol2qm74 5173 8 g g NN cord-015021-pol2qm74 5173 9 , , , cord-015021-pol2qm74 5173 10 n>_6 n>_6 NNP cord-015021-pol2qm74 5173 11 / / SYM cord-015021-pol2qm74 5173 12 group group NN cord-015021-pol2qm74 5173 13 ; ; : cord-015021-pol2qm74 5173 14 pentobarbital pentobarbital NNP cord-015021-pol2qm74 5173 15 50 50 CD cord-015021-pol2qm74 5173 16 mg mg NNP cord-015021-pol2qm74 5173 17 / / SYM cord-015021-pol2qm74 5173 18 kg kg NNP cord-015021-pol2qm74 5173 19 ) ) -RRB- cord-015021-pol2qm74 5173 20 with with IN cord-015021-pol2qm74 5173 21 hemorrhage hemorrhage NN cord-015021-pol2qm74 5173 22 for for IN cord-015021-pol2qm74 5173 23 60 60 CD cord-015021-pol2qm74 5173 24 rain rain NN cord-015021-pol2qm74 5173 25 at at IN cord-015021-pol2qm74 5173 26 40 40 CD cord-015021-pol2qm74 5173 27 mm mm NN cord-015021-pol2qm74 5173 28 Hg hg NN cord-015021-pol2qm74 5173 29 . . . cord-015021-pol2qm74 5174 1 Reperfusion reperfusion NN cord-015021-pol2qm74 5174 2 by by IN cord-015021-pol2qm74 5174 3 Ringer Ringer NNP cord-015021-pol2qm74 5174 4 's 's POS cord-015021-pol2qm74 5174 5 lactate lactate NN cord-015021-pol2qm74 5174 6 ( ( -LRB- cord-015021-pol2qm74 5174 7 2 2 CD cord-015021-pol2qm74 5174 8 x x SYM cord-015021-pol2qm74 5174 9 maximal maximal JJ cord-015021-pol2qm74 5174 10 bleed bleed NN cord-015021-pol2qm74 5174 11 out/60 out/60 NNP cord-015021-pol2qm74 5174 12 min min NN cord-015021-pol2qm74 5174 13 ) ) -RRB- cord-015021-pol2qm74 5174 14 and and CC cord-015021-pol2qm74 5174 15 60 60 CD cord-015021-pol2qm74 5174 16 % % NN cord-015021-pol2qm74 5174 17 of of IN cord-015021-pol2qm74 5174 18 citrated citrated JJ cord-015021-pol2qm74 5174 19 shed shed JJ cord-015021-pol2qm74 5174 20 blood blood NN cord-015021-pol2qm74 5174 21 . . . cord-015021-pol2qm74 5175 1 TNFcz TNFcz NNP cord-015021-pol2qm74 5175 2 - - HYPH cord-015021-pol2qm74 5175 3 MoAB MoAB NNP cord-015021-pol2qm74 5176 1 ( ( -LRB- cord-015021-pol2qm74 5176 2 TN3 TN3 NNP cord-015021-pol2qm74 5176 3 , , , cord-015021-pol2qm74 5176 4 CeUtech CeUtech NNP cord-015021-pol2qm74 5176 5 , , , cord-015021-pol2qm74 5176 6 20 20 CD cord-015021-pol2qm74 5176 7 mg mg NNP cord-015021-pol2qm74 5176 8 / / SYM cord-015021-pol2qm74 5176 9 kg kg NNS cord-015021-pol2qm74 5176 10 in in IN cord-015021-pol2qm74 5176 11 0.9 0.9 CD cord-015021-pol2qm74 5176 12 % % NN cord-015021-pol2qm74 5176 13 NaC1 nac1 NN cord-015021-pol2qm74 5176 14 ) ) -RRB- cord-015021-pol2qm74 5176 15 infused infuse VBN cord-015021-pol2qm74 5176 16 during during IN cord-015021-pol2qm74 5176 17 fLrst fLrst NNP cord-015021-pol2qm74 5176 18 5 5 CD cord-015021-pol2qm74 5176 19 min min NN cord-015021-pol2qm74 5176 20 of of IN cord-015021-pol2qm74 5176 21 reperfusion reperfusion NN cord-015021-pol2qm74 5176 22 . . . cord-015021-pol2qm74 5177 1 At at IN cord-015021-pol2qm74 5177 2 baseline baseline NN cord-015021-pol2qm74 5177 3 , , , cord-015021-pol2qm74 5177 4 end end NN cord-015021-pol2qm74 5177 5 of of IN cord-015021-pol2qm74 5177 6 ischemia ischemia NN cord-015021-pol2qm74 5177 7 and and CC cord-015021-pol2qm74 5177 8 60 60 CD cord-015021-pol2qm74 5177 9 min min NN cord-015021-pol2qm74 5177 10 of of IN cord-015021-pol2qm74 5177 11 reperfusion reperfusion NN cord-015021-pol2qm74 5177 12 , , , cord-015021-pol2qm74 5177 13 hepatecyte hepatecyte NNP cord-015021-pol2qm74 5177 14 isolation isolation NN cord-015021-pol2qm74 5177 15 by by IN cord-015021-pol2qm74 5177 16 liver liver NN cord-015021-pol2qm74 5177 17 collagenase collagenase NNP cord-015021-pol2qm74 5177 18 perfusion perfusion NN cord-015021-pol2qm74 5177 19 . . . cord-015021-pol2qm74 5177 20 " " '' cord-015021-pol2qm74 5177 21 45 45 CD cord-015021-pol2qm74 5177 22 Hepatocyte Hepatocyte NNP cord-015021-pol2qm74 5177 23 incubation incubation NN cord-015021-pol2qm74 5177 24 ( ( -LRB- cord-015021-pol2qm74 5177 25 30 30 CD cord-015021-pol2qm74 5177 26 mg mg NNP cord-015021-pol2qm74 5177 27 w.w./ml w.w./ml NNP cord-015021-pol2qm74 5177 28 ) ) -RRB- cord-015021-pol2qm74 5177 29 with with IN cord-015021-pol2qm74 5177 30 CaCI CaCI NNP cord-015021-pol2qm74 5177 31 2 2 CD cord-015021-pol2qm74 5177 32 ( ( -LRB- cord-015021-pol2qm74 5177 33 0.05 0.05 CD cord-015021-pol2qm74 5177 34 2 2 CD cord-015021-pol2qm74 5177 35 + + CD cord-015021-pol2qm74 5178 1 2 2 LS cord-015021-pol2qm74 5178 2 + + SYM cord-015021-pol2qm74 5178 3 2 2 CD cord-015021-pol2qm74 5178 4 + + CD cord-015021-pol2qm74 5178 5 MBq MBq NNS cord-015021-pol2qm74 5178 6 / / SYM cord-015021-pol2qm74 5178 7 ml ml NN cord-015021-pol2qm74 5178 8 ) ) -RRB- cord-015021-pol2qm74 5178 9 for for IN cord-015021-pol2qm74 5178 10 60 60 CD cord-015021-pol2qm74 5178 11 rain rain NN cord-015021-pol2qm74 5178 12 ( ( -LRB- cord-015021-pol2qm74 5178 13 Ca Ca MD cord-015021-pol2qm74 5178 14 influx influx VB cord-015021-pol2qm74 5178 15 [ [ -LRB- cord-015021-pol2qm74 5178 16 slope slope NN cord-015021-pol2qm74 5178 17 , , , cord-015021-pol2qm74 5178 18 1 1 CD cord-015021-pol2qm74 5178 19 / / SYM cord-015021-pol2qm74 5178 20 mini mini NN cord-015021-pol2qm74 5178 21 ; ; : cord-015021-pol2qm74 5178 22 Ca Ca MD cord-015021-pol2qm74 5178 23 uptake uptake NN cord-015021-pol2qm74 5178 24 [ [ -LRB- cord-015021-pol2qm74 5178 25 nmol nmol NNP cord-015021-pol2qm74 5178 26 Ca Ca NNP cord-015021-pol2qm74 5178 27 /mg /mg CD cord-015021-pol2qm74 5178 28 protein protein NN cord-015021-pol2qm74 5178 29 ] ] -RRB- cord-015021-pol2qm74 5178 30 ) ) -RRB- cord-015021-pol2qm74 5179 1 w/ w/ NNP cord-015021-pol2qm74 5179 2 and and CC cord-015021-pol2qm74 5179 3 w/o without IN cord-015021-pol2qm74 5179 4 epinephrine epinephrine NN cord-015021-pol2qm74 5179 5 ( ( -LRB- cord-015021-pol2qm74 5179 6 EPI EPI NNP cord-015021-pol2qm74 5179 7 , , , cord-015021-pol2qm74 5179 8 100 100 CD cord-015021-pol2qm74 5179 9 nM nm NN cord-015021-pol2qm74 5179 10 ) ) -RRB- cord-015021-pol2qm74 5179 11 . . . cord-015021-pol2qm74 5180 1 Hepatecyte Hepatecyte NNP cord-015021-pol2qm74 5180 2 resuspension resuspension NN cord-015021-pol2qm74 5180 3 in in IN cord-015021-pol2qm74 5180 4 radioisotope radioisotope NN cord-015021-pol2qm74 5180 5 - - HYPH cord-015021-pol2qm74 5180 6 free free JJ cord-015021-pol2qm74 5180 7 medium medium NN cord-015021-pol2qm74 5180 8 and and CC cord-015021-pol2qm74 5180 9 farther farther JJ cord-015021-pol2qm74 5180 10 incubation incubation NN cord-015021-pol2qm74 5180 11 ( ( -LRB- cord-015021-pol2qm74 5180 12 exchangeable exchangeable JJ cord-015021-pol2qm74 5181 1 Ca ca NN cord-015021-pol2qm74 5181 2 2 2 CD cord-015021-pol2qm74 5181 3 + + CD cord-015021-pol2qm74 5181 4 ( ( -LRB- cord-015021-pol2qm74 5181 5 Ca2+ex Ca2+ex NNP cord-015021-pol2qm74 5181 6 ) ) -RRB- cord-015021-pol2qm74 5182 1 [ [ -LRB- cord-015021-pol2qm74 5182 2 nmol nmol JJ cord-015021-pol2qm74 5182 3 Ca2+/mg Ca2+/mg NNP cord-015021-pol2qm74 5182 4 protein protein NN cord-015021-pol2qm74 5182 5 ] ] -RRB- cord-015021-pol2qm74 5182 6 ; ; . cord-015021-pol2qm74 5183 1 Ca ca NN cord-015021-pol2qm74 5183 2 2 2 CD cord-015021-pol2qm74 5183 3 + + CD cord-015021-pol2qm74 5183 4 membrane membrane NN cord-015021-pol2qm74 5183 5 flux flux NN cord-015021-pol2qm74 5183 6 [ [ -LRB- cord-015021-pol2qm74 5183 7 nmol nmol JJ cord-015021-pol2qm74 5183 8 Ca2+/mg Ca2+/mg NNP cord-015021-pol2qm74 5183 9 protein'min protein'min CD cord-015021-pol2qm74 5183 10 ] ] -RRB- cord-015021-pol2qm74 5183 11 ) ) -RRB- cord-015021-pol2qm74 5183 12 . . . cord-015021-pol2qm74 5184 1 During during IN cord-015021-pol2qm74 5184 2 incubation incubation NN cord-015021-pol2qm74 5184 3 , , , cord-015021-pol2qm74 5184 4 aliquots aliquot NNS cord-015021-pol2qm74 5184 5 ( ( -LRB- cord-015021-pol2qm74 5184 6 100 100 CD cord-015021-pol2qm74 5184 7 ~tl ~tl JJ cord-015021-pol2qm74 5184 8 ) ) -RRB- cord-015021-pol2qm74 5184 9 were be VBD cord-015021-pol2qm74 5184 10 centrifuged centrifuge VBN cord-015021-pol2qm74 5184 11 through through IN cord-015021-pol2qm74 5184 12 oil oil NN cord-015021-pol2qm74 5184 13 / / SYM cord-015021-pol2qm74 5184 14 lanthanum lanthanum NN cord-015021-pol2qm74 5184 15 gradient gradient NN cord-015021-pol2qm74 5184 16 and and CC cord-015021-pol2qm74 5184 17 acivity acivity NN cord-015021-pol2qm74 5184 18 measured measure VBN cord-015021-pol2qm74 5184 19 by by IN cord-015021-pol2qm74 5184 20 scintillation scintillation NN cord-015021-pol2qm74 5184 21 counting counting NN cord-015021-pol2qm74 5184 22 . . . cord-015021-pol2qm74 5185 1 Statistics statistic NNS cord-015021-pol2qm74 5185 2 : : : cord-015021-pol2qm74 5185 3 ANOVA ANOVA NNP cord-015021-pol2qm74 5185 4 . . . cord-015021-pol2qm74 5186 1 Mean mean JJ cord-015021-pol2qm74 5186 2 + + CC cord-015021-pol2qm74 5186 3 SEM sem NN cord-015021-pol2qm74 5186 4 . . . cord-015021-pol2qm74 5187 1 Results result NNS cord-015021-pol2qm74 5187 2 . . . cord-015021-pol2qm74 5188 1 Hepatocyte Hepatocyte NNP cord-015021-pol2qm74 5188 2 Ca2+ex Ca2+ex NNP cord-015021-pol2qm74 5188 3 and and CC cord-015021-pol2qm74 5188 4 membrane membrane NN cord-015021-pol2qm74 5189 1 Ca ca NN cord-015021-pol2qm74 5189 2 2 2 CD cord-015021-pol2qm74 5189 3 + + CD cord-015021-pol2qm74 5190 1 flux flux NN cord-015021-pol2qm74 5190 2 were be VBD cord-015021-pol2qm74 5190 3 significantly significantly RB cord-015021-pol2qm74 5190 4 increased increase VBN cord-015021-pol2qm74 5190 5 at at IN cord-015021-pol2qm74 5190 6 both both DT cord-015021-pol2qm74 5190 7 , , , cord-015021-pol2qm74 5190 8 the the DT cord-015021-pol2qm74 5190 9 end end NN cord-015021-pol2qm74 5190 10 of of IN cord-015021-pol2qm74 5190 11 ischemia ischemia NN cord-015021-pol2qm74 5190 12 ( ( -LRB- cord-015021-pol2qm74 5190 13 14.3+.9 14.3+.9 CD cord-015021-pol2qm74 5190 14 ; ; : cord-015021-pol2qm74 5190 15 0.41+.05 0.41+.05 LS cord-015021-pol2qm74 5190 16 ) ) -RRB- cord-015021-pol2qm74 5190 17 and and CC cord-015021-pol2qm74 5190 18 reperfusion reperfusion NN cord-015021-pol2qm74 5190 19 ( ( -LRB- cord-015021-pol2qm74 5190 20 16.4+.9 16.4+.9 CD cord-015021-pol2qm74 5190 21 ; ; : cord-015021-pol2qm74 5190 22 0.50+.2 0.50+.2 CD cord-015021-pol2qm74 5190 23 ) ) -RRB- cord-015021-pol2qm74 5190 24 , , , cord-015021-pol2qm74 5190 25 as as IN cord-015021-pol2qm74 5190 26 compared compare VBN cord-015021-pol2qm74 5190 27 to to IN cord-015021-pol2qm74 5190 28 sham sham NN cord-015021-pol2qm74 5190 29 - - HYPH cord-015021-pol2qm74 5190 30 operated operate VBN cord-015021-pol2qm74 5190 31 animals animal NNS cord-015021-pol2qm74 5190 32 ( ( -LRB- cord-015021-pol2qm74 5190 33 7.6+_.5 7.6+_.5 NNP cord-015021-pol2qm74 5190 34 ; ; : cord-015021-pol2qm74 5190 35 0.09+.02)(19<.05 0.09+.02)(19<.05 CD cord-015021-pol2qm74 5190 36 ) ) -RRB- cord-015021-pol2qm74 5190 37 . . . cord-015021-pol2qm74 5191 1 TNFc~-MoAB TNFc~-MoAB NNP cord-015021-pol2qm74 5192 1 treatment treatment NN cord-015021-pol2qm74 5192 2 significantly significantly RB cord-015021-pol2qm74 5192 3 prevented prevent VBD cord-015021-pol2qm74 5192 4 reperfusion reperfusion NN cord-015021-pol2qm74 5192 5 - - HYPH cord-015021-pol2qm74 5192 6 induced induce VBN cord-015021-pol2qm74 5192 7 increase increase NN cord-015021-pol2qm74 5192 8 of of IN cord-015021-pol2qm74 5192 9 Ca2+ex Ca2+ex NNP cord-015021-pol2qm74 5192 10 ( ( -LRB- cord-015021-pol2qm74 5192 11 10+.8 10+.8 CD cord-015021-pol2qm74 5192 12 ) ) -RRB- cord-015021-pol2qm74 5192 13 and and CC cord-015021-pol2qm74 5192 14 membrane membrane NN cord-015021-pol2qm74 5193 1 Ca ca NN cord-015021-pol2qm74 5193 2 2 2 CD cord-015021-pol2qm74 5193 3 + + CC cord-015021-pol2qm74 5193 4 flux flux NN cord-015021-pol2qm74 5193 5 ( ( -LRB- cord-015021-pol2qm74 5193 6 0.17+.03)(p<.01 0.17+.03)(p<.01 CD cord-015021-pol2qm74 5193 7 ) ) -RRB- cord-015021-pol2qm74 5193 8 . . . cord-015021-pol2qm74 5194 1 Fast Fast NNP cord-015021-pol2qm74 5194 2 Ca Ca NNP cord-015021-pol2qm74 5194 3 2 2 CD cord-015021-pol2qm74 5194 4 + + CC cord-015021-pol2qm74 5194 5 influx influx NN cord-015021-pol2qm74 5194 6 was be VBD cord-015021-pol2qm74 5194 7 significantly significantly RB cord-015021-pol2qm74 5194 8 increased increase VBN cord-015021-pol2qm74 5194 9 by by IN cord-015021-pol2qm74 5194 10 epinephrine epinephrine NN cord-015021-pol2qm74 5194 11 in in IN cord-015021-pol2qm74 5194 12 hepatecytes hepatecyte NNS cord-015021-pol2qm74 5194 13 from from IN cord-015021-pol2qm74 5194 14 sham sham NN cord-015021-pol2qm74 5194 15 - - HYPH cord-015021-pol2qm74 5194 16 operated operate VBN cord-015021-pol2qm74 5194 17 rats rat NNS cord-015021-pol2qm74 5194 18 ( ( -LRB- cord-015021-pol2qm74 5194 19 0.23+.03 0.23+.03 CD cord-015021-pol2qm74 5194 20 vs. vs. IN cord-015021-pol2qm74 5194 21 EPI EPI NNP cord-015021-pol2qm74 5194 22 : : : cord-015021-pol2qm74 5194 23 0.52+.1 0.52+.1 CD cord-015021-pol2qm74 5194 24 , , , cord-015021-pol2qm74 5194 25 p p NN cord-015021-pol2qm74 5194 26 < < XX cord-015021-pol2qm74 5194 27 .05 .05 NFP cord-015021-pol2qm74 5194 28 ) ) -RRB- cord-015021-pol2qm74 5194 29 . . . cord-015021-pol2qm74 5195 1 This this DT cord-015021-pol2qm74 5195 2 hormone hormone NN cord-015021-pol2qm74 5195 3 effect effect NN cord-015021-pol2qm74 5195 4 was be VBD cord-015021-pol2qm74 5195 5 not not RB cord-015021-pol2qm74 5195 6 observed observe VBN cord-015021-pol2qm74 5195 7 in in IN cord-015021-pol2qm74 5195 8 isehemia isehemia NNP cord-015021-pol2qm74 5195 9 ( ( -LRB- cord-015021-pol2qm74 5195 10 0.47+.05 0.47+.05 NNP cord-015021-pol2qm74 5195 11 , , , cord-015021-pol2qm74 5195 12 EPI EPI NNP cord-015021-pol2qm74 5195 13 : : : cord-015021-pol2qm74 5195 14 0.6!-_.2 0.6!-_.2 LS cord-015021-pol2qm74 5195 15 ) ) -RRB- cord-015021-pol2qm74 5195 16 or or CC cord-015021-pol2qm74 5195 17 reperfusion reperfusion NN cord-015021-pol2qm74 5195 18 ( ( -LRB- cord-015021-pol2qm74 5195 19 untreated untreated JJ cord-015021-pol2qm74 5195 20 : : : cord-015021-pol2qm74 5196 1 0.13+.06 0.13+.06 CD cord-015021-pol2qm74 5197 1 , , , cord-015021-pol2qm74 5197 2 EPI EPI NNP cord-015021-pol2qm74 5197 3 : : : cord-015021-pol2qm74 5197 4 0.07+.01 0.07+.01 CD cord-015021-pol2qm74 5197 5 ; ; . cord-015021-pol2qm74 5198 1 TNFt~-MoAB TNFt~-MoAB NNP cord-015021-pol2qm74 5198 2 : : : cord-015021-pol2qm74 5198 3 0.26_+.04 0.26_+.04 CD cord-015021-pol2qm74 5198 4 , , , cord-015021-pol2qm74 5198 5 EPI EPI NNP cord-015021-pol2qm74 5198 6 : : : cord-015021-pol2qm74 5198 7 0.33+.07 0.33+.07 LS cord-015021-pol2qm74 5198 8 ) ) -RRB- cord-015021-pol2qm74 5198 9 . . . cord-015021-pol2qm74 5199 1 Conclusion conclusion NN cord-015021-pol2qm74 5199 2 . . . cord-015021-pol2qm74 5200 1 The the DT cord-015021-pol2qm74 5200 2 present present JJ cord-015021-pol2qm74 5200 3 study study NN cord-015021-pol2qm74 5200 4 clearly clearly RB cord-015021-pol2qm74 5200 5 demonstrated demonstrate VBD cord-015021-pol2qm74 5200 6 hepato hepato JJ cord-015021-pol2qm74 5200 7 - - HYPH cord-015021-pol2qm74 5200 8 cellular cellular JJ cord-015021-pol2qm74 5201 1 Ca ca NN cord-015021-pol2qm74 5201 2 2 2 CD cord-015021-pol2qm74 5201 3 + + CC cord-015021-pol2qm74 5201 4 overload overload NN cord-015021-pol2qm74 5201 5 in in IN cord-015021-pol2qm74 5201 6 ischemia ischemia NN cord-015021-pol2qm74 5201 7 and and CC cord-015021-pol2qm74 5201 8 reperfusion reperfusion NN cord-015021-pol2qm74 5201 9 as as IN cord-015021-pol2qm74 5201 10 a a DT cord-015021-pol2qm74 5201 11 result result NN cord-015021-pol2qm74 5201 12 of of IN cord-015021-pol2qm74 5201 13 hemorrhagic hemorrhagic JJ cord-015021-pol2qm74 5201 14 shock shock NN cord-015021-pol2qm74 5201 15 . . . cord-015021-pol2qm74 5202 1 Analysis analysis NN cord-015021-pol2qm74 5202 2 of of IN cord-015021-pol2qm74 5202 3 membrane membrane NN cord-015021-pol2qm74 5203 1 Ca ca NN cord-015021-pol2qm74 5203 2 2 2 CD cord-015021-pol2qm74 5203 3 + + SYM cord-015021-pol2qm74 5203 4 fluxes flux NNS cord-015021-pol2qm74 5203 5 and and CC cord-015021-pol2qm74 5203 6 hormone hormone NN cord-015021-pol2qm74 5204 1 Ca ca NN cord-015021-pol2qm74 5204 2 2 2 CD cord-015021-pol2qm74 5204 3 + + CC cord-015021-pol2qm74 5204 4 mobilization mobilization NN cord-015021-pol2qm74 5204 5 suggests suggest VBZ cord-015021-pol2qm74 5204 6 disturbances disturbance NNS cord-015021-pol2qm74 5204 7 of of IN cord-015021-pol2qm74 5204 8 membrane membrane NN cord-015021-pol2qm74 5205 1 Ca ca NN cord-015021-pol2qm74 5205 2 2 2 CD cord-015021-pol2qm74 5205 3 + + SYM cord-015021-pol2qm74 5205 4 transport transport NN cord-015021-pol2qm74 5205 5 mechanisms mechanism NNS cord-015021-pol2qm74 5205 6 , , , cord-015021-pol2qm74 5205 7 e.g. e.g. RB cord-015021-pol2qm74 5205 8 through through IN cord-015021-pol2qm74 5205 9 Ca2 ca2 CD cord-015021-pol2qm74 5205 10 + + CC cord-015021-pol2qm74 5206 1 -ATPases -ATPases NNP cord-015021-pol2qm74 5206 2 . . . cord-015021-pol2qm74 5207 1 Reperfusion reperfusion NN cord-015021-pol2qm74 5207 2 - - HYPH cord-015021-pol2qm74 5207 3 induced induce VBN cord-015021-pol2qm74 5207 4 oxygen oxygen NN cord-015021-pol2qm74 5207 5 free free JJ cord-015021-pol2qm74 5207 6 radical radical JJ cord-015021-pol2qm74 5207 7 generation generation NN cord-015021-pol2qm74 5207 8 which which WDT cord-015021-pol2qm74 5207 9 affect affect VBP cord-015021-pol2qm74 5207 10 exchange exchange NN cord-015021-pol2qm74 5207 11 kinetics kinetic NNS cord-015021-pol2qm74 5207 12 of of IN cord-015021-pol2qm74 5207 13 cellular cellular JJ cord-015021-pol2qm74 5208 1 Ca ca NN cord-015021-pol2qm74 5208 2 2 2 CD cord-015021-pol2qm74 5208 3 + + SYM cord-015021-pol2qm74 5208 4 buffering buffering NN cord-015021-pol2qm74 5208 5 compartments compartment NNS cord-015021-pol2qm74 5208 6 might may MD cord-015021-pol2qm74 5208 7 also also RB cord-015021-pol2qm74 5208 8 be be VB cord-015021-pol2qm74 5208 9 operative operative JJ cord-015021-pol2qm74 5208 10 . . . cord-015021-pol2qm74 5209 1 Prevention prevention NN cord-015021-pol2qm74 5209 2 by by IN cord-015021-pol2qm74 5209 3 TNFct TNFct NNP cord-015021-pol2qm74 5209 4 - - HYPH cord-015021-pol2qm74 5209 5 MoAB MoAB NNP cord-015021-pol2qm74 5209 6 indicates indicate VBZ cord-015021-pol2qm74 5209 7 the the DT cord-015021-pol2qm74 5209 8 pivotal pivotal JJ cord-015021-pol2qm74 5209 9 role role NN cord-015021-pol2qm74 5209 10 of of IN cord-015021-pol2qm74 5209 11 TNF TNF NNP cord-015021-pol2qm74 5209 12 as as IN cord-015021-pol2qm74 5209 13 an an DT cord-015021-pol2qm74 5209 14 early early JJ cord-015021-pol2qm74 5209 15 inflammatory inflammatory JJ cord-015021-pol2qm74 5209 16 mediator mediator NN cord-015021-pol2qm74 5209 17 of of IN cord-015021-pol2qm74 5209 18 hepatocellular hepatocellular JJ cord-015021-pol2qm74 5209 19 alterations alteration NNS cord-015021-pol2qm74 5209 20 in in IN cord-015021-pol2qm74 5209 21 signal signal JJ cord-015021-pol2qm74 5209 22 transduetion transduetion NN cord-015021-pol2qm74 5209 23 mechanisms mechanism NNS cord-015021-pol2qm74 5209 24 and and CC cord-015021-pol2qm74 5209 25 cellular cellular JJ cord-015021-pol2qm74 5209 26 homeostasis homeostasis NN cord-015021-pol2qm74 5209 27 . . . cord-015021-pol2qm74 5210 1 Although although IN cord-015021-pol2qm74 5210 2 the the DT cord-015021-pol2qm74 5210 3 precise precise JJ cord-015021-pol2qm74 5210 4 mechanism mechanism NN cord-015021-pol2qm74 5210 5 has have VBZ cord-015021-pol2qm74 5210 6 not not RB cord-015021-pol2qm74 5210 7 yet yet RB cord-015021-pol2qm74 5210 8 been be VBN cord-015021-pol2qm74 5210 9 elucidated elucidate VBN cord-015021-pol2qm74 5210 10 , , , cord-015021-pol2qm74 5210 11 bacterial bacterial JJ cord-015021-pol2qm74 5210 12 translocation translocation NN cord-015021-pol2qm74 5210 13 and and CC cord-015021-pol2qm74 5210 14 endotoxin endotoxin NN cord-015021-pol2qm74 5210 15 absorption absorption NN cord-015021-pol2qm74 5210 16 have have VBP cord-015021-pol2qm74 5210 17 been be VBN cord-015021-pol2qm74 5210 18 frequently frequently RB cord-015021-pol2qm74 5210 19 shown show VBN cord-015021-pol2qm74 5210 20 after after IN cord-015021-pol2qm74 5210 21 burn burn NN cord-015021-pol2qm74 5210 22 , , , cord-015021-pol2qm74 5210 23 and and CC cord-015021-pol2qm74 5210 24 have have VBP cord-015021-pol2qm74 5210 25 been be VBN cord-015021-pol2qm74 5210 26 postulated postulate VBN cord-015021-pol2qm74 5210 27 to to TO cord-015021-pol2qm74 5210 28 be be VB cord-015021-pol2qm74 5210 29 one one CD cord-015021-pol2qm74 5210 30 of of IN cord-015021-pol2qm74 5210 31 the the DT cord-015021-pol2qm74 5210 32 underlying underlie VBG cord-015021-pol2qm74 5210 33 processes process NNS cord-015021-pol2qm74 5210 34 of of IN cord-015021-pol2qm74 5210 35 sepsis sepsis NN cord-015021-pol2qm74 5210 36 . . . cord-015021-pol2qm74 5211 1 The the DT cord-015021-pol2qm74 5211 2 purpose purpose NN cord-015021-pol2qm74 5211 3 of of IN cord-015021-pol2qm74 5211 4 the the DT cord-015021-pol2qm74 5211 5 current current JJ cord-015021-pol2qm74 5211 6 study study NN cord-015021-pol2qm74 5211 7 is be VBZ cord-015021-pol2qm74 5211 8 to to TO cord-015021-pol2qm74 5211 9 define define VB cord-015021-pol2qm74 5211 10 the the DT cord-015021-pol2qm74 5211 11 hemodynamic hemodynamic JJ cord-015021-pol2qm74 5211 12 response response NN cord-015021-pol2qm74 5211 13 of of IN cord-015021-pol2qm74 5211 14 the the DT cord-015021-pol2qm74 5211 15 liver liver NN cord-015021-pol2qm74 5211 16 to to IN cord-015021-pol2qm74 5211 17 endotoxin endotoxin NN cord-015021-pol2qm74 5211 18 release release NN cord-015021-pol2qm74 5211 19 in in IN cord-015021-pol2qm74 5211 20 burns burn NNS cord-015021-pol2qm74 5211 21 , , , cord-015021-pol2qm74 5211 22 in in IN cord-015021-pol2qm74 5211 23 correlation correlation NN cord-015021-pol2qm74 5211 24 to to IN cord-015021-pol2qm74 5211 25 bacterial bacterial JJ cord-015021-pol2qm74 5211 26 translocation translocation NN cord-015021-pol2qm74 5211 27 . . . cord-015021-pol2qm74 5212 1 Twelve twelve CD cord-015021-pol2qm74 5212 2 female female JJ cord-015021-pol2qm74 5212 3 minipigs minipig NNS cord-015021-pol2qm74 5212 4 , , , cord-015021-pol2qm74 5212 5 weighing weigh VBG cord-015021-pol2qm74 5212 6 20 20 CD cord-015021-pol2qm74 5212 7 - - SYM cord-015021-pol2qm74 5212 8 28 28 CD cord-015021-pol2qm74 5212 9 Kg Kg NNP cord-015021-pol2qm74 5212 10 , , , cord-015021-pol2qm74 5212 11 underwent undergo VBD cord-015021-pol2qm74 5212 12 a a DT cord-015021-pol2qm74 5212 13 laparotomy laparotomy NN cord-015021-pol2qm74 5212 14 & & CC cord-015021-pol2qm74 5212 15 transition transition NN cord-015021-pol2qm74 5212 16 time time NN cord-015021-pol2qm74 5212 17 ultrasonic ultrasonic JJ cord-015021-pol2qm74 5212 18 flow flow NN cord-015021-pol2qm74 5212 19 probes probe NNS cord-015021-pol2qm74 5212 20 were be VBD cord-015021-pol2qm74 5212 21 positioned position VBN cord-015021-pol2qm74 5212 22 on on IN cord-015021-pol2qm74 5212 23 the the DT cord-015021-pol2qm74 5212 24 portal portal JJ cord-015021-pol2qm74 5212 25 vein vein NN cord-015021-pol2qm74 5212 26 , , , cord-015021-pol2qm74 5212 27 the the DT cord-015021-pol2qm74 5212 28 common common JJ cord-015021-pol2qm74 5212 29 hepatic hepatic JJ cord-015021-pol2qm74 5212 30 artery artery NN cord-015021-pol2qm74 5212 31 , , , cord-015021-pol2qm74 5212 32 and and CC cord-015021-pol2qm74 5212 33 the the DT cord-015021-pol2qm74 5212 34 superior superior JJ cord-015021-pol2qm74 5212 35 mesenteric mesenteric JJ cord-015021-pol2qm74 5212 36 artery artery NN cord-015021-pol2qm74 5212 37 . . . cord-015021-pol2qm74 5213 1 6.5 6.5 CD cord-015021-pol2qm74 5213 2 Fr Fr NNP cord-015021-pol2qm74 5213 3 catheters catheter NNS cord-015021-pol2qm74 5213 4 were be VBD cord-015021-pol2qm74 5213 5 inserted insert VBN cord-015021-pol2qm74 5213 6 in in IN cord-015021-pol2qm74 5213 7 the the DT cord-015021-pol2qm74 5213 8 superior superior JJ cord-015021-pol2qm74 5213 9 mesenteric mesenteric JJ cord-015021-pol2qm74 5213 10 vein vein NN cord-015021-pol2qm74 5213 11 and and CC cord-015021-pol2qm74 5213 12 the the DT cord-015021-pol2qm74 5213 13 left left JJ cord-015021-pol2qm74 5213 14 hepatic hepatic JJ cord-015021-pol2qm74 5213 15 vein vein NN cord-015021-pol2qm74 5213 16 . . . cord-015021-pol2qm74 5214 1 A a DT cord-015021-pol2qm74 5214 2 jejunostomy jejunostomy NN cord-015021-pol2qm74 5214 3 was be VBD cord-015021-pol2qm74 5214 4 also also RB cord-015021-pol2qm74 5214 5 performed perform VBN cord-015021-pol2qm74 5214 6 . . . cord-015021-pol2qm74 5215 1 After after IN cord-015021-pol2qm74 5215 2 five five CD cord-015021-pol2qm74 5215 3 days day NNS cord-015021-pol2qm74 5215 4 all all DT cord-015021-pol2qm74 5215 5 animals animal NNS cord-015021-pol2qm74 5215 6 were be VBD cord-015021-pol2qm74 5215 7 anaesthetized anaesthetize VBN cord-015021-pol2qm74 5215 8 and and CC cord-015021-pol2qm74 5215 9 randomized randomize VBN cord-015021-pol2qm74 5215 10 to to TO cord-015021-pol2qm74 5215 11 receive receive VB cord-015021-pol2qm74 5215 12 40 40 CD cord-015021-pol2qm74 5215 13 % % NN cord-015021-pol2qm74 5215 14 of of IN cord-015021-pol2qm74 5215 15 TBS tbs NN cord-015021-pol2qm74 5216 1 A a DT cord-015021-pol2qm74 5216 2 third third JJ cord-015021-pol2qm74 5216 3 degree degree NN cord-015021-pol2qm74 5216 4 burn burn NN cord-015021-pol2qm74 5216 5 . . . cord-015021-pol2qm74 5217 1 Eighteen eighteen CD cord-015021-pol2qm74 5217 2 hours hour NNS cord-015021-pol2qm74 5217 3 after after IN cord-015021-pol2qm74 5217 4 burn burn NN cord-015021-pol2qm74 5217 5 . . . cord-015021-pol2qm74 5218 1 100 100 CD cord-015021-pol2qm74 5218 2 gg gg NNP cord-015021-pol2qm74 5218 3 / / SYM cord-015021-pol2qm74 5218 4 Kg Kg NNP cord-015021-pol2qm74 5218 5 E. E. NNP cord-015021-pol2qm74 5218 6 Coli Coli NNP cord-015021-pol2qm74 5218 7 LPS LPS NNP cord-015021-pol2qm74 5218 8 was be VBD cord-015021-pol2qm74 5218 9 intravenously intravenously RB cord-015021-pol2qm74 5218 10 administered administer VBN cord-015021-pol2qm74 5218 11 over over IN cord-015021-pol2qm74 5218 12 30 30 CD cord-015021-pol2qm74 5218 13 rain rain NN cord-015021-pol2qm74 5218 14 . . . cord-015021-pol2qm74 5219 1 alI ali JJ cord-015021-pol2qm74 5219 2 animals animal NNS cord-015021-pol2qm74 5219 3 were be VBD cord-015021-pol2qm74 5219 4 studied study VBN cord-015021-pol2qm74 5219 5 for for IN cord-015021-pol2qm74 5219 6 additional additional JJ cord-015021-pol2qm74 5219 7 24 24 CD cord-015021-pol2qm74 5219 8 hours hour NNS cord-015021-pol2qm74 5219 9 and and CC cord-015021-pol2qm74 5219 10 then then RB cord-015021-pol2qm74 5219 11 sacrificed sacrifice VBD cord-015021-pol2qm74 5219 12 . . . cord-015021-pol2qm74 5220 1 Several several JJ cord-015021-pol2qm74 5220 2 recent recent JJ cord-015021-pol2qm74 5220 3 data datum NNS cord-015021-pol2qm74 5220 4 suggest suggest VBP cord-015021-pol2qm74 5220 5 that that IN cord-015021-pol2qm74 5220 6 in in IN cord-015021-pol2qm74 5220 7 severe severe JJ cord-015021-pol2qm74 5220 8 injuries injury NNS cord-015021-pol2qm74 5220 9 , , , cord-015021-pol2qm74 5220 10 such such JJ cord-015021-pol2qm74 5220 11 as as IN cord-015021-pol2qm74 5220 12 shock shock NN cord-015021-pol2qm74 5220 13 state state NN cord-015021-pol2qm74 5220 14 , , , cord-015021-pol2qm74 5220 15 the the DT cord-015021-pol2qm74 5220 16 gradual gradual JJ cord-015021-pol2qm74 5220 17 activation activation NN cord-015021-pol2qm74 5220 18 of of IN cord-015021-pol2qm74 5220 19 Kupffer Kupffer NNP cord-015021-pol2qm74 5220 20 cells cell NNS cord-015021-pol2qm74 5220 21 and and CC cord-015021-pol2qm74 5220 22 the the DT cord-015021-pol2qm74 5220 23 excessive excessive JJ cord-015021-pol2qm74 5220 24 release release NN cord-015021-pol2qm74 5220 25 of of IN cord-015021-pol2qm74 5220 26 destructive destructive JJ cord-015021-pol2qm74 5220 27 and and CC cord-015021-pol2qm74 5220 28 immunosuppresive immunosuppresive JJ cord-015021-pol2qm74 5220 29 products product NNS cord-015021-pol2qm74 5220 30 from from IN cord-015021-pol2qm74 5220 31 macrophages macrophage NNS cord-015021-pol2qm74 5220 32 may may MD cord-015021-pol2qm74 5220 33 contribute contribute VB cord-015021-pol2qm74 5220 34 to to IN cord-015021-pol2qm74 5220 35 the the DT cord-015021-pol2qm74 5220 36 development development NN cord-015021-pol2qm74 5220 37 of of IN cord-015021-pol2qm74 5220 38 " " `` cord-015021-pol2qm74 5220 39 multiple multiple JJ cord-015021-pol2qm74 5220 40 organ organ NN cord-015021-pol2qm74 5220 41 failure failure NN cord-015021-pol2qm74 5220 42 " " '' cord-015021-pol2qm74 5220 43 . . . cord-015021-pol2qm74 5221 1 In in IN cord-015021-pol2qm74 5221 2 in in IN cord-015021-pol2qm74 5221 3 vivo vivo NN cord-015021-pol2qm74 5221 4 experiments experiment NNS cord-015021-pol2qm74 5221 5 in in IN cord-015021-pol2qm74 5221 6 mice mouse NNS cord-015021-pol2qm74 5221 7 , , , cord-015021-pol2qm74 5221 8 the the DT cord-015021-pol2qm74 5221 9 effect effect NN cord-015021-pol2qm74 5221 10 of of IN cord-015021-pol2qm74 5221 11 Kupffer Kupffer NNP cord-015021-pol2qm74 5221 12 cell cell NN cord-015021-pol2qm74 5221 13 phagocytosis phagocytosis NN cord-015021-pol2qm74 5221 14 blockade blockade NN cord-015021-pol2qm74 5221 15 on on IN cord-015021-pol2qm74 5221 16 the the DT cord-015021-pol2qm74 5221 17 correlation correlation NN cord-015021-pol2qm74 5221 18 between between IN cord-015021-pol2qm74 5221 19 the the DT cord-015021-pol2qm74 5221 20 tissue tissue NN cord-015021-pol2qm74 5221 21 distribution distribution NN cord-015021-pol2qm74 5221 22 of of IN cord-015021-pol2qm74 5221 23 LPS lp NNS cord-015021-pol2qm74 5221 24 , , , cord-015021-pol2qm74 5221 25 endotoxin endotoxin NN cord-015021-pol2qm74 5221 26 sensitivity sensitivity NN cord-015021-pol2qm74 5221 27 and and CC cord-015021-pol2qm74 5221 28 LPS LPS NNP cord-015021-pol2qm74 5221 29 - - HYPH cord-015021-pol2qm74 5221 30 induced induce VBN cord-015021-pol2qm74 5221 31 TNF TNF NNP cord-015021-pol2qm74 5221 32 production production NN cord-015021-pol2qm74 5221 33 was be VBD cord-015021-pol2qm74 5221 34 investigated investigate VBN cord-015021-pol2qm74 5221 35 . . . cord-015021-pol2qm74 5222 1 To to TO cord-015021-pol2qm74 5222 2 depress depress VB cord-015021-pol2qm74 5222 3 the the DT cord-015021-pol2qm74 5222 4 activity activity NN cord-015021-pol2qm74 5222 5 of of IN cord-015021-pol2qm74 5222 6 the the DT cord-015021-pol2qm74 5222 7 Kupffer Kupffer NNP cord-015021-pol2qm74 5222 8 cells cell NNS cord-015021-pol2qm74 5222 9 , , , cord-015021-pol2qm74 5222 10 gadolinium gadolinium NN cord-015021-pol2qm74 5222 11 chloride chloride NN cord-015021-pol2qm74 5222 12 ( ( -LRB- cord-015021-pol2qm74 5222 13 GdC13 GdC13 NNS cord-015021-pol2qm74 5222 14 ) ) -RRB- cord-015021-pol2qm74 5222 15 or or CC cord-015021-pol2qm74 5222 16 carrageenan carrageenan NN cord-015021-pol2qm74 5222 17 was be VBD cord-015021-pol2qm74 5222 18 used use VBN cord-015021-pol2qm74 5222 19 . . . cord-015021-pol2qm74 5223 1 Th th JJ cord-015021-pol2qm74 5223 2 ~ ~ NFP cord-015021-pol2qm74 5223 3 e e LS cord-015021-pol2qm74 5223 4 studies study NNS cord-015021-pol2qm74 5223 5 indicate indicate VBP cord-015021-pol2qm74 5223 6 the the DT cord-015021-pol2qm74 5223 7 dissociation dissociation NN cord-015021-pol2qm74 5223 8 of of IN cord-015021-pol2qm74 5223 9 tissue tissue NN cord-015021-pol2qm74 5223 10 localisation localisation NN cord-015021-pol2qm74 5223 11 of of IN cord-015021-pol2qm74 5223 12 Cr Cr NNP cord-015021-pol2qm74 5223 13 Jllabelled Jllabelled NNP cord-015021-pol2qm74 5223 14 endotoxin endotoxin NN cord-015021-pol2qm74 5223 15 and and CC cord-015021-pol2qm74 5223 16 endotoxin endotoxin NN cord-015021-pol2qm74 5223 17 lethalithy lethalithy NNP cord-015021-pol2qm74 5223 18 . . . cord-015021-pol2qm74 5224 1 Both both DT cord-015021-pol2qm74 5224 2 GdC13 GdC13 NNPS cord-015021-pol2qm74 5224 3 and and CC cord-015021-pol2qm74 5224 4 carrageenan carrageenan NN cord-015021-pol2qm74 5224 5 depressed depress VBD cord-015021-pol2qm74 5224 6 Kupffer Kupffer NNP cord-015021-pol2qm74 5224 7 cell cell NN cord-015021-pol2qm74 5224 8 activity activity NN cord-015021-pol2qm74 5224 9 , , , cord-015021-pol2qm74 5224 10 but but CC cord-015021-pol2qm74 5224 11 endotoxin endotoxin NN cord-015021-pol2qm74 5224 12 sensitivity sensitivity NN cord-015021-pol2qm74 5224 13 was be VBD cord-015021-pol2qm74 5224 14 enhanced enhance VBN cord-015021-pol2qm74 5224 15 only only RB cord-015021-pol2qm74 5224 16 by by IN cord-015021-pol2qm74 5224 17 carragenan carragenan NNP cord-015021-pol2qm74 5224 18 treatment treatment NN cord-015021-pol2qm74 5224 19 . . . cord-015021-pol2qm74 5225 1 However however RB cord-015021-pol2qm74 5225 2 , , , cord-015021-pol2qm74 5225 3 there there EX cord-015021-pol2qm74 5225 4 was be VBD cord-015021-pol2qm74 5225 5 a a DT cord-015021-pol2qm74 5225 6 close close JJ cord-015021-pol2qm74 5225 7 correlation correlation NN cord-015021-pol2qm74 5225 8 between between IN cord-015021-pol2qm74 5225 9 the the DT cord-015021-pol2qm74 5225 10 sensitivity sensitivity NN cord-015021-pol2qm74 5225 11 to to IN cord-015021-pol2qm74 5225 12 LPS LPS NNP cord-015021-pol2qm74 5225 13 and and CC cord-015021-pol2qm74 5225 14 LPS LPS NNP cord-015021-pol2qm74 5225 15 - - HYPH cord-015021-pol2qm74 5225 16 induced induce VBN cord-015021-pol2qm74 5225 17 TNF TNF NNP cord-015021-pol2qm74 5225 18 production production NN cord-015021-pol2qm74 5225 19 as as IN cord-015021-pol2qm74 5225 20 measured measure VBN cord-015021-pol2qm74 5225 21 in in IN cord-015021-pol2qm74 5225 22 the the DT cord-015021-pol2qm74 5225 23 serum serum NN cord-015021-pol2qm74 5225 24 , , , cord-015021-pol2qm74 5225 25 since since IN cord-015021-pol2qm74 5225 26 LPSinduced LPSinduced NNP cord-015021-pol2qm74 5225 27 TNF TNF NNP cord-015021-pol2qm74 5225 28 production production NN cord-015021-pol2qm74 5225 29 was be VBD cord-015021-pol2qm74 5225 30 enhanced enhance VBN cord-015021-pol2qm74 5225 31 only only RB cord-015021-pol2qm74 5225 32 by by IN cord-015021-pol2qm74 5225 33 carrageenan carrageenan NN cord-015021-pol2qm74 5225 34 treatment treatment NN cord-015021-pol2qm74 5225 35 . . . cord-015021-pol2qm74 5226 1 On on IN cord-015021-pol2qm74 5226 2 the the DT cord-015021-pol2qm74 5226 3 other other JJ cord-015021-pol2qm74 5226 4 hand hand NN cord-015021-pol2qm74 5226 5 , , , cord-015021-pol2qm74 5226 6 GdC13 gdc13 JJ cord-015021-pol2qm74 5226 7 pretreatment pretreatment NN cord-015021-pol2qm74 5226 8 significantly significantly RB cord-015021-pol2qm74 5226 9 increased increase VBD cord-015021-pol2qm74 5226 10 TNF TNF NNP cord-015021-pol2qm74 5226 11 production production NN cord-015021-pol2qm74 5226 12 in in IN cord-015021-pol2qm74 5226 13 the the DT cord-015021-pol2qm74 5226 14 spleen spleen NN cord-015021-pol2qm74 5226 15 . . . cord-015021-pol2qm74 5227 1 These these DT cord-015021-pol2qm74 5227 2 results result NNS cord-015021-pol2qm74 5227 3 support support VBP cord-015021-pol2qm74 5227 4 our -PRON- PRP$ cord-015021-pol2qm74 5227 5 earlier early JJR cord-015021-pol2qm74 5227 6 findings finding NNS cord-015021-pol2qm74 5227 7 that that IN cord-015021-pol2qm74 5227 8 GdC13-indueed GdC13-indueed NNP cord-015021-pol2qm74 5227 9 Kupffer Kupffer NNP cord-015021-pol2qm74 5227 10 cell cell NN cord-015021-pol2qm74 5227 11 phagocytosis phagocytosis NN cord-015021-pol2qm74 5227 12 blockade blockade NN cord-015021-pol2qm74 5227 13 leads lead NNS cord-015021-pol2qm74 5227 14 to to IN cord-015021-pol2qm74 5227 15 activation activation NN cord-015021-pol2qm74 5227 16 of of IN cord-015021-pol2qm74 5227 17 the the DT cord-015021-pol2qm74 5227 18 spleen spleen NN cord-015021-pol2qm74 5227 19 , , , cord-015021-pol2qm74 5227 20 and and CC cord-015021-pol2qm74 5227 21 may may MD cord-015021-pol2qm74 5227 22 explain explain VB cord-015021-pol2qm74 5227 23 some some DT cord-015021-pol2qm74 5227 24 of of IN cord-015021-pol2qm74 5227 25 the the DT cord-015021-pol2qm74 5227 26 immunological immunological JJ cord-015021-pol2qm74 5227 27 effects effect NNS cord-015021-pol2qm74 5227 28 of of IN cord-015021-pol2qm74 5227 29 GdC13 GdC13 NNS cord-015021-pol2qm74 5227 30 . . . cord-015021-pol2qm74 5228 1 Inositol(l Inositol(l NNS cord-015021-pol2qm74 5229 1 , , , cord-015021-pol2qm74 5229 2 4 4 CD cord-015021-pol2qm74 5229 3 , , , cord-015021-pol2qm74 5229 4 5 5 CD cord-015021-pol2qm74 5229 5 ) ) -RRB- cord-015021-pol2qm74 5229 6 triphosphate triphosphate NN cord-015021-pol2qm74 5229 7 ( ( -LRB- cord-015021-pol2qm74 5229 8 IP3 IP3 NNP cord-015021-pol2qm74 5229 9 ) ) -RRB- cord-015021-pol2qm74 5229 10 has have VBZ cord-015021-pol2qm74 5229 11 been be VBN cord-015021-pol2qm74 5229 12 proposed propose VBN cord-015021-pol2qm74 5229 13 as as IN cord-015021-pol2qm74 5229 14 a a DT cord-015021-pol2qm74 5229 15 second second JJ cord-015021-pol2qm74 5229 16 messenger messenger NN cord-015021-pol2qm74 5229 17 for for IN cord-015021-pol2qm74 5229 18 calcium calcium NN cord-015021-pol2qm74 5229 19 mobilization mobilization NN cord-015021-pol2qm74 5229 20 . . . cord-015021-pol2qm74 5230 1 The the DT cord-015021-pol2qm74 5230 2 addition addition NN cord-015021-pol2qm74 5230 3 of of IN cord-015021-pol2qm74 5230 4 IP3 IP3 NNP cord-015021-pol2qm74 5230 5 at at IN cord-015021-pol2qm74 5230 6 low low JJ cord-015021-pol2qm74 5230 7 concentration concentration NN cord-015021-pol2qm74 5230 8 has have VBZ cord-015021-pol2qm74 5230 9 been be VBN cord-015021-pol2qm74 5230 10 shown show VBN cord-015021-pol2qm74 5230 11 to to TO cord-015021-pol2qm74 5230 12 cause cause VB cord-015021-pol2qm74 5230 13 calcium calcium NN cord-015021-pol2qm74 5230 14 release release NN cord-015021-pol2qm74 5230 15 from from IN cord-015021-pol2qm74 5230 16 intracellular intracellular JJ cord-015021-pol2qm74 5230 17 microsomal microsomal NNP cord-015021-pol2qm74 5230 18 store store NN cord-015021-pol2qm74 5230 19 in in IN cord-015021-pol2qm74 5230 20 rat rat NN cord-015021-pol2qm74 5230 21 hepatocytes hepatocyte NNS cord-015021-pol2qm74 5230 22 . . . cord-015021-pol2qm74 5231 1 The the DT cord-015021-pol2qm74 5231 2 effects effect NNS cord-015021-pol2qm74 5231 3 of of IN cord-015021-pol2qm74 5231 4 sepsis sepsis NN cord-015021-pol2qm74 5231 5 on on IN cord-015021-pol2qm74 5231 6 the the DT cord-015021-pol2qm74 5231 7 IP3 ip3 NN cord-015021-pol2qm74 5231 8 binding bind VBG cord-015021-pol2qm74 5231 9 from from IN cord-015021-pol2qm74 5231 10 microsomal microsomal NNP cord-015021-pol2qm74 5231 11 fraction fraction NN cord-015021-pol2qm74 5231 12 of of IN cord-015021-pol2qm74 5231 13 rat rat NN cord-015021-pol2qm74 5231 14 hepatocytes hepatocyte NNS cord-015021-pol2qm74 5231 15 during during IN cord-015021-pol2qm74 5231 16 sepsis sepsis NN cord-015021-pol2qm74 5231 17 were be VBD cord-015021-pol2qm74 5231 18 investigated investigate VBN cord-015021-pol2qm74 5231 19 . . . cord-015021-pol2qm74 5232 1 Sepsis sepsis NN cord-015021-pol2qm74 5232 2 was be VBD cord-015021-pol2qm74 5232 3 induced induce VBN cord-015021-pol2qm74 5232 4 by by IN cord-015021-pol2qm74 5232 5 cecal cecal JJ cord-015021-pol2qm74 5232 6 ligation ligation NN cord-015021-pol2qm74 5232 7 & & CC cord-015021-pol2qm74 5232 8 puncture puncture NN cord-015021-pol2qm74 5232 9 ( ( -LRB- cord-015021-pol2qm74 5232 10 CLP CLP NNP cord-015021-pol2qm74 5232 11 ) ) -RRB- cord-015021-pol2qm74 5232 12 . . . cord-015021-pol2qm74 5233 1 Control control NN cord-015021-pol2qm74 5233 2 rats rat NNS cord-015021-pol2qm74 5233 3 were be VBD cord-015021-pol2qm74 5233 4 sham sham JJ cord-015021-pol2qm74 5233 5 - - HYPH cord-015021-pol2qm74 5233 6 operated operate VBN cord-015021-pol2qm74 5233 7 . . . cord-015021-pol2qm74 5234 1 Three three CD cord-015021-pol2qm74 5234 2 microsomal microsomal NNP cord-015021-pol2qm74 5234 3 fractions fraction NNS cord-015021-pol2qm74 5234 4 ( ( -LRB- cord-015021-pol2qm74 5234 5 rough rough JJ cord-015021-pol2qm74 5234 6 , , , cord-015021-pol2qm74 5234 7 intermediate intermediate JJ cord-015021-pol2qm74 5234 8 and and CC cord-015021-pol2qm74 5234 9 smooth smooth JJ cord-015021-pol2qm74 5234 10 ) ) -RRB- cord-015021-pol2qm74 5234 11 were be VBD cord-015021-pol2qm74 5234 12 isolated isolate VBN cord-015021-pol2qm74 5234 13 from from IN cord-015021-pol2qm74 5234 14 rat rat NN cord-015021-pol2qm74 5234 15 liver liver NN cord-015021-pol2qm74 5234 16 . . . cord-015021-pol2qm74 5235 1 Study study NN cord-015021-pol2qm74 5235 2 of of IN cord-015021-pol2qm74 5235 3 IP3 IP3 NNP cord-015021-pol2qm74 5235 4 receptor receptor NN cord-015021-pol2qm74 5235 5 binding binding NN cord-015021-pol2qm74 5235 6 was be VBD cord-015021-pol2qm74 5235 7 performed perform VBN cord-015021-pol2qm74 5235 8 with with IN cord-015021-pol2qm74 5235 9 tridium tridium NN cord-015021-pol2qm74 5235 10 label label NN cord-015021-pol2qm74 5235 11 IP3 IP3 NNP cord-015021-pol2qm74 5235 12 . . . cord-015021-pol2qm74 5236 1 The the DT cord-015021-pol2qm74 5236 2 results result NNS cord-015021-pol2qm74 5236 3 shewed shew VBD cord-015021-pol2qm74 5236 4 that that IN cord-015021-pol2qm74 5236 5 the the DT cord-015021-pol2qm74 5236 6 IP3 IP3 NNP cord-015021-pol2qm74 5236 7 binding binding NN cord-015021-pol2qm74 5236 8 was be VBD cord-015021-pol2qm74 5236 9 significantly significantly RB cord-015021-pol2qm74 5236 10 depressed depress VBN cord-015021-pol2qm74 5236 11 by by IN cord-015021-pol2qm74 5236 12 40 40 CD cord-015021-pol2qm74 5236 13 - - SYM cord-015021-pol2qm74 5236 14 47 47 CD cord-015021-pol2qm74 5236 15 % % NN cord-015021-pol2qm74 5236 16 ( ( -LRB- cord-015021-pol2qm74 5236 17 p<0.05 p<0.05 CD cord-015021-pol2qm74 5236 18 ) ) -RRB- cord-015021-pol2qm74 5236 19 during during IN cord-015021-pol2qm74 5236 20 late late JJ cord-015021-pol2qm74 5236 21 sepsis sepsis NN cord-015021-pol2qm74 5236 22 ( ( -LRB- cord-015021-pol2qm74 5236 23 18 18 CD cord-015021-pol2qm74 5236 24 hrs hrs NN cord-015021-pol2qm74 5236 25 after after IN cord-015021-pol2qm74 5236 26 CLP CLP NNP cord-015021-pol2qm74 5236 27 ) ) -RRB- cord-015021-pol2qm74 5236 28 , , , cord-015021-pol2qm74 5236 29 but but CC cord-015021-pol2qm74 5236 30 not not RB cord-015021-pol2qm74 5236 31 in in IN cord-015021-pol2qm74 5236 32 early early JJ cord-015021-pol2qm74 5236 33 sepsis sepsis NN cord-015021-pol2qm74 5236 34 ( ( -LRB- cord-015021-pol2qm74 5236 35 9 9 CD cord-015021-pol2qm74 5236 36 hrs hrs NN cord-015021-pol2qm74 5236 37 after after IN cord-015021-pol2qm74 5236 38 CLP CLP NNP cord-015021-pol2qm74 5236 39 ) ) -RRB- cord-015021-pol2qm74 5236 40 . . . cord-015021-pol2qm74 5237 1 The the DT cord-015021-pol2qm74 5237 2 IP3 IP3 NNP cord-015021-pol2qm74 5237 3 binding bind VBG cord-015021-pol2qm74 5237 4 depression depression NN cord-015021-pol2qm74 5237 5 during during IN cord-015021-pol2qm74 5237 6 late late JJ cord-015021-pol2qm74 5237 7 sepsis sepsis NN cord-015021-pol2qm74 5237 8 was be VBD cord-015021-pol2qm74 5237 9 most most RBS cord-015021-pol2qm74 5237 10 significant significant JJ cord-015021-pol2qm74 5237 11 on on IN cord-015021-pol2qm74 5237 12 rough rough JJ cord-015021-pol2qm74 5237 13 and and CC cord-015021-pol2qm74 5237 14 intermediate intermediate JJ cord-015021-pol2qm74 5237 15 endoplasmic endoplasmic NN cord-015021-pol2qm74 5237 16 reticulum reticulum NN cord-015021-pol2qm74 5237 17 ( ( -LRB- cord-015021-pol2qm74 5237 18 p<0.05 p<0.05 NNP cord-015021-pol2qm74 5237 19 ) ) -RRB- cord-015021-pol2qm74 5237 20 , , , cord-015021-pol2qm74 5237 21 but but CC cord-015021-pol2qm74 5237 22 not not RB cord-015021-pol2qm74 5237 23 on on IN cord-015021-pol2qm74 5237 24 smooth smooth JJ cord-015021-pol2qm74 5237 25 subfraction subfraction NN cord-015021-pol2qm74 5237 26 . . . cord-015021-pol2qm74 5238 1 Since since IN cord-015021-pol2qm74 5238 2 IP3 IP3 NNP cord-015021-pol2qm74 5238 3 binding binding NN cord-015021-pol2qm74 5238 4 plays play VBZ cord-015021-pol2qm74 5238 5 an an DT cord-015021-pol2qm74 5238 6 important important JJ cord-015021-pol2qm74 5238 7 role role NN cord-015021-pol2qm74 5238 8 in in IN cord-015021-pol2qm74 5238 9 the the DT cord-015021-pol2qm74 5238 10 regulation regulation NN cord-015021-pol2qm74 5238 11 of of IN cord-015021-pol2qm74 5238 12 intracellular intracellular JJ cord-015021-pol2qm74 5238 13 calcium calcium NN cord-015021-pol2qm74 5238 14 homeostasis homeostasis NN cord-015021-pol2qm74 5238 15 in in IN cord-015021-pol2qm74 5238 16 hepatocytes hepatocyte NNS cord-015021-pol2qm74 5238 17 , , , cord-015021-pol2qm74 5238 18 an an DT cord-015021-pol2qm74 5238 19 impairment impairment NN cord-015021-pol2qm74 5238 20 in in IN cord-015021-pol2qm74 5238 21 the the DT cord-015021-pol2qm74 5238 22 calcium calcium NN cord-015021-pol2qm74 5238 23 release release NN cord-015021-pol2qm74 5238 24 due due IN cord-015021-pol2qm74 5238 25 to to IN cord-015021-pol2qm74 5238 26 depressed depressed JJ cord-015021-pol2qm74 5238 27 IP3 ip3 NN cord-015021-pol2qm74 5238 28 binding bind VBG cord-015021-pol2qm74 5238 29 on on IN cord-015021-pol2qm74 5238 30 smooth smooth JJ cord-015021-pol2qm74 5238 31 and and CC cord-015021-pol2qm74 5238 32 intermediate intermediate JJ cord-015021-pol2qm74 5238 33 endoplasmic endoplasmic NN cord-015021-pol2qm74 5238 34 reticulum reticulum NN cord-015021-pol2qm74 5238 35 during during IN cord-015021-pol2qm74 5238 36 late late JJ cord-015021-pol2qm74 5238 37 sepsis sepsis NN cord-015021-pol2qm74 5238 38 may may MD cord-015021-pol2qm74 5238 39 have have VB cord-015021-pol2qm74 5238 40 a a DT cord-015021-pol2qm74 5238 41 pathophysiological pathophysiological JJ cord-015021-pol2qm74 5238 42 significance significance NN cord-015021-pol2qm74 5238 43 in in IN cord-015021-pol2qm74 5238 44 contributing contribute VBG cord-015021-pol2qm74 5238 45 to to IN cord-015021-pol2qm74 5238 46 the the DT cord-015021-pol2qm74 5238 47 development development NN cord-015021-pol2qm74 5238 48 of of IN cord-015021-pol2qm74 5238 49 altered alter VBN cord-015021-pol2qm74 5238 50 hepatic hepatic JJ cord-015021-pol2qm74 5238 51 metabolism metabolism NN cord-015021-pol2qm74 5238 52 during during IN cord-015021-pol2qm74 5238 53 septic septic JJ cord-015021-pol2qm74 5238 54 shock shock NN cord-015021-pol2qm74 5238 55 . . . cord-015021-pol2qm74 5239 1 Septic septic JJ cord-015021-pol2qm74 5239 2 organ organ NN cord-015021-pol2qm74 5239 3 failure failure NN cord-015021-pol2qm74 5239 4 is be VBZ cord-015021-pol2qm74 5239 5 currently currently RB cord-015021-pol2qm74 5239 6 recognized recognize VBN cord-015021-pol2qm74 5239 7 as as IN cord-015021-pol2qm74 5239 8 an an DT cord-015021-pol2qm74 5239 9 overactivation overactivation NN cord-015021-pol2qm74 5239 10 of of IN cord-015021-pol2qm74 5239 11 the the DT cord-015021-pol2qm74 5239 12 nonspecific nonspecific JJ cord-015021-pol2qm74 5239 13 immune immune JJ cord-015021-pol2qm74 5239 14 system system NN cord-015021-pol2qm74 5239 15 by by IN cord-015021-pol2qm74 5239 16 bacterial bacterial JJ cord-015021-pol2qm74 5239 17 stimuli stimulus NNS cord-015021-pol2qm74 5239 18 giving give VBG cord-015021-pol2qm74 5239 19 rise rise NN cord-015021-pol2qm74 5239 20 to to IN cord-015021-pol2qm74 5239 21 proinflammatory proinflammatory JJ cord-015021-pol2qm74 5239 22 mediators mediator NNS cord-015021-pol2qm74 5239 23 . . . cord-015021-pol2qm74 5240 1 Little little JJ cord-015021-pol2qm74 5240 2 is be VBZ cord-015021-pol2qm74 5240 3 known know VBN cord-015021-pol2qm74 5240 4 about about IN cord-015021-pol2qm74 5240 5 the the DT cord-015021-pol2qm74 5240 6 mechanisms mechanism NNS cord-015021-pol2qm74 5240 7 of of IN cord-015021-pol2qm74 5240 8 the the DT cord-015021-pol2qm74 5240 9 resulting result VBG cord-015021-pol2qm74 5240 10 cellular cellular JJ cord-015021-pol2qm74 5240 11 injury injury NN cord-015021-pol2qm74 5240 12 . . . cord-015021-pol2qm74 5241 1 Here here RB cord-015021-pol2qm74 5241 2 , , , cord-015021-pol2qm74 5241 3 a a DT cord-015021-pol2qm74 5241 4 synergism synergism NN cord-015021-pol2qm74 5241 5 is be VBZ cord-015021-pol2qm74 5241 6 described describe VBN cord-015021-pol2qm74 5241 7 between between IN cord-015021-pol2qm74 5241 8 TNF TNF NNP cord-015021-pol2qm74 5241 9 as as IN cord-015021-pol2qm74 5241 10 a a DT cord-015021-pol2qm74 5241 11 major major JJ cord-015021-pol2qm74 5241 12 mediator mediator NN cord-015021-pol2qm74 5241 13 of of IN cord-015021-pol2qm74 5241 14 septic septic JJ cord-015021-pol2qm74 5241 15 organ organ NN cord-015021-pol2qm74 5241 16 injury injury NN cord-015021-pol2qm74 5241 17 released release VBN cord-015021-pol2qm74 5241 18 by by IN cord-015021-pol2qm74 5241 19 macrophages macrophage NNS cord-015021-pol2qm74 5241 20 and and CC cord-015021-pol2qm74 5241 21 hydrogen hydrogen NN cord-015021-pol2qm74 5241 22 peroxide peroxide NN cord-015021-pol2qm74 5241 23 ( ( -LRB- cord-015021-pol2qm74 5241 24 H202 H202 NNP cord-015021-pol2qm74 5241 25 ) ) -RRB- cord-015021-pol2qm74 5241 26 as as IN cord-015021-pol2qm74 5241 27 a a DT cord-015021-pol2qm74 5241 28 representative representative NN cord-015021-pol2qm74 5241 29 of of IN cord-015021-pol2qm74 5241 30 reactive reactive JJ cord-015021-pol2qm74 5241 31 oxygen oxygen NN cord-015021-pol2qm74 5241 32 species specie NNS cord-015021-pol2qm74 5241 33 as as IN cord-015021-pol2qm74 5241 34 formed form VBN cord-015021-pol2qm74 5241 35 by by IN cord-015021-pol2qm74 5241 36 e.g. e.g. JJ cord-015021-pol2qm74 5241 37 neutrophils neutrophil NNS cord-015021-pol2qm74 5241 38 . . . cord-015021-pol2qm74 5242 1 Rat rat NN cord-015021-pol2qm74 5242 2 hepatocytes hepatocyte NNS cord-015021-pol2qm74 5242 3 are be VBP cord-015021-pol2qm74 5242 4 only only RB cord-015021-pol2qm74 5242 5 slightly slightly RB cord-015021-pol2qm74 5242 6 sensitive sensitive JJ cord-015021-pol2qm74 5242 7 to to IN cord-015021-pol2qm74 5242 8 either either DT cord-015021-pol2qm74 5242 9 agent agent NN cord-015021-pol2qm74 5242 10 alone alone RB cord-015021-pol2qm74 5242 11 . . . cord-015021-pol2qm74 5243 1 When when WRB cord-015021-pol2qm74 5243 2 treated treat VBN cord-015021-pol2qm74 5243 3 with with IN cord-015021-pol2qm74 5243 4 a a DT cord-015021-pol2qm74 5243 5 conbination conbination NN cord-015021-pol2qm74 5243 6 of of IN cord-015021-pol2qm74 5243 7 TNF TNF NNP cord-015021-pol2qm74 5243 8 and and CC cord-015021-pol2qm74 5243 9 H#09 H#09 VBZ cord-015021-pol2qm74 5243 10 a a DT cord-015021-pol2qm74 5243 11 stronq stronq NN cord-015021-pol2qm74 5243 12 synergistic synergistic JJ cord-015021-pol2qm74 5243 13 toxicity toxicity NN cord-015021-pol2qm74 5243 14 was be VBD cord-015021-pol2qm74 5243 15 found find VBN cord-015021-pol2qm74 5243 16 , , , cord-015021-pol2qm74 5243 17 especially especially RB cord-015021-pol2qm74 5243 18 w w NN cord-015021-pol2qm74 5243 19 ~ ~ CD cord-015021-pol2qm74 5243 20 e~ e~ XX cord-015021-pol2qm74 5244 1 TNF tnf NN cord-015021-pol2qm74 5244 2 - - HYPH cord-015021-pol2qm74 5244 3 treatment treatment NN cord-015021-pol2qm74 5244 4 preceeded preceede VBD cord-015021-pol2qm74 5244 5 challenge challenge NN cord-015021-pol2qm74 5244 6 with with IN cord-015021-pol2qm74 5244 7 H h NN cord-015021-pol2qm74 5244 8 ~ ~ CD cord-015021-pol2qm74 5244 9 O~. o~. NN cord-015021-pol2qm74 5245 1 We -PRON- PRP cord-015021-pol2qm74 5245 2 have have VBP cord-015021-pol2qm74 5245 3 recently recently RB cord-015021-pol2qm74 5245 4 described describe VBN cord-015021-pol2qm74 5245 5 a a DT cord-015021-pol2qm74 5245 6 coculture coculture NN cord-015021-pol2qm74 5245 7 model model NN cord-015021-pol2qm74 5245 8 bfZrat bfzrat CD cord-015021-pol2qm74 5245 9 liver liver NN cord-015021-pol2qm74 5245 10 macrophaqes macrophaqes NN cord-015021-pol2qm74 5245 11 and and CC cord-015021-pol2qm74 5245 12 hepatocytes hepatocyte NNS cord-015021-pol2qm74 5245 13 where where WRB cord-015021-pol2qm74 5245 14 LPS LPS NNP cord-015021-pol2qm74 5245 15 induces induce VBZ cord-015021-pol2qm74 5245 16 hepatocyte hepatocyte NN cord-015021-pol2qm74 5245 17 cell cell NN cord-015021-pol2qm74 5245 18 death death NN cord-015021-pol2qm74 5245 19 partially partially RB cord-015021-pol2qm74 5245 20 mediated mediate VBN cord-015021-pol2qm74 5245 21 by by IN cord-015021-pol2qm74 5245 22 macrophage macrophage NN cord-015021-pol2qm74 5245 23 TNF TNF NNP cord-015021-pol2qm74 5245 24 release release NN cord-015021-pol2qm74 5245 25 . . . cord-015021-pol2qm74 5246 1 When when WRB cord-015021-pol2qm74 5246 2 H202 H202 NNP cord-015021-pol2qm74 5246 3 was be VBD cord-015021-pol2qm74 5246 4 also also RB cord-015021-pol2qm74 5246 5 employed employ VBN cord-015021-pol2qm74 5246 6 in in IN cord-015021-pol2qm74 5246 7 fhis fhis DT cord-015021-pol2qm74 5246 8 more more RBR cord-015021-pol2qm74 5246 9 complex complex JJ cord-015021-pol2qm74 5246 10 cellular cellular JJ cord-015021-pol2qm74 5246 11 system system NN cord-015021-pol2qm74 5246 12 a a DT cord-015021-pol2qm74 5246 13 similar similar JJ cord-015021-pol2qm74 5246 14 synergism synergism NN cord-015021-pol2qm74 5246 15 was be VBD cord-015021-pol2qm74 5246 16 found find VBN cord-015021-pol2qm74 5246 17 : : : cord-015021-pol2qm74 5246 18 The the DT cord-015021-pol2qm74 5246 19 ECc~ ECc~ NNP cord-015021-pol2qm74 5246 20 of of IN cord-015021-pol2qm74 5246 21 LPS LPS NNP cord-015021-pol2qm74 5246 22 was be VBD cord-015021-pol2qm74 5246 23 62 62 CD cord-015021-pol2qm74 5246 24 consecutive consecutive JJ cord-015021-pol2qm74 5246 25 patients patient NNS cord-015021-pol2qm74 5246 26 with with IN cord-015021-pol2qm74 5246 27 liver liver NN cord-015021-pol2qm74 5246 28 cirrhosis cirrhosis NN cord-015021-pol2qm74 5246 29 admitted admit VBD cord-015021-pol2qm74 5246 30 to to IN cord-015021-pol2qm74 5246 31 the the DT cord-015021-pol2qm74 5246 32 Department Department NNP cord-015021-pol2qm74 5246 33 of of IN cord-015021-pol2qm74 5246 34 Surgery Surgery NNP cord-015021-pol2qm74 5246 35 over over IN cord-015021-pol2qm74 5246 36 a a DT cord-015021-pol2qm74 5246 37 1 1 CD cord-015021-pol2qm74 5246 38 year year NN cord-015021-pol2qm74 5246 39 period period NN cord-015021-pol2qm74 5246 40 from from IN cord-015021-pol2qm74 5246 41 January January NNP cord-015021-pol2qm74 5246 42 to to IN cord-015021-pol2qm74 5246 43 December December NNP cord-015021-pol2qm74 5246 44 1992 1992 CD cord-015021-pol2qm74 5246 45 were be VBD cord-015021-pol2qm74 5246 46 studied study VBN cord-015021-pol2qm74 5246 47 for for IN cord-015021-pol2qm74 5246 48 their -PRON- PRP$ cord-015021-pol2qm74 5246 49 complement complement NN cord-015021-pol2qm74 5246 50 profiles profile NNS cord-015021-pol2qm74 5246 51 in in IN cord-015021-pol2qm74 5246 52 relation relation NN cord-015021-pol2qm74 5246 53 to to IN cord-015021-pol2qm74 5246 54 other other JJ cord-015021-pol2qm74 5246 55 parameters parameter NNS cord-015021-pol2qm74 5246 56 of of IN cord-015021-pol2qm74 5246 57 liver liver NN cord-015021-pol2qm74 5246 58 function function NN cord-015021-pol2qm74 5246 59 , , , cord-015021-pol2qm74 5246 60 The the DT cord-015021-pol2qm74 5246 61 aim aim NN cord-015021-pol2qm74 5246 62 of of IN cord-015021-pol2qm74 5246 63 the the DT cord-015021-pol2qm74 5246 64 study study NN cord-015021-pol2qm74 5246 65 was be VBD cord-015021-pol2qm74 5246 66 to to TO cord-015021-pol2qm74 5246 67 determine determine VB cord-015021-pol2qm74 5246 68 if if IN cord-015021-pol2qm74 5246 69 a a DT cord-015021-pol2qm74 5246 70 direct direct JJ cord-015021-pol2qm74 5246 71 correlation correlation NN cord-015021-pol2qm74 5246 72 existed exist VBD cord-015021-pol2qm74 5246 73 between between IN cord-015021-pol2qm74 5246 74 low low JJ cord-015021-pol2qm74 5246 75 complement complement NN cord-015021-pol2qm74 5246 76 levels level NNS cord-015021-pol2qm74 5246 77 and and CC cord-015021-pol2qm74 5246 78 end end NN cord-015021-pol2qm74 5246 79 stage stage NN cord-015021-pol2qm74 5246 80 liver liver NN cord-015021-pol2qm74 5246 81 cirrhosis cirrhosis NN cord-015021-pol2qm74 5246 82 . . . cord-015021-pol2qm74 5247 1 Cirrhotic cirrhotic JJ cord-015021-pol2qm74 5247 2 patients patient NNS cord-015021-pol2qm74 5247 3 were be VBD cord-015021-pol2qm74 5247 4 divided divide VBN cord-015021-pol2qm74 5247 5 into into IN cord-015021-pol2qm74 5247 6 Child child NN cord-015021-pol2qm74 5247 7 's 's POS cord-015021-pol2qm74 5247 8 A a NN cord-015021-pol2qm74 5247 9 , , , cord-015021-pol2qm74 5247 10 B b NN cord-015021-pol2qm74 5247 11 and and CC cord-015021-pol2qm74 5247 12 C c NN cord-015021-pol2qm74 5247 13 categories category NNS cord-015021-pol2qm74 5247 14 using use VBG cord-015021-pol2qm74 5247 15 Child child NN cord-015021-pol2qm74 5247 16 's 's POS cord-015021-pol2qm74 5247 17 classification classification NN cord-015021-pol2qm74 5247 18 . . . cord-015021-pol2qm74 5248 1 Complement complement JJ cord-015021-pol2qm74 5248 2 levels level NNS cord-015021-pol2qm74 5248 3 ( ( -LRB- cord-015021-pol2qm74 5248 4 C3 c3 NN cord-015021-pol2qm74 5248 5 , , , cord-015021-pol2qm74 5248 6 C4 C4 NNP cord-015021-pol2qm74 5248 7 ) ) -RRB- cord-015021-pol2qm74 5248 8 were be VBD cord-015021-pol2qm74 5248 9 measured measure VBN cord-015021-pol2qm74 5248 10 and and CC cord-015021-pol2qm74 5248 11 functional functional JJ cord-015021-pol2qm74 5248 12 assay assay NN cord-015021-pol2qm74 5248 13 for for IN cord-015021-pol2qm74 5248 14 complement complement NN cord-015021-pol2qm74 5248 15 ( ( -LRB- cord-015021-pol2qm74 5248 16 CH50 CH50 NNP cord-015021-pol2qm74 5248 17 ) ) -RRB- cord-015021-pol2qm74 5248 18 were be VBD cord-015021-pol2qm74 5248 19 performed perform VBN cord-015021-pol2qm74 5248 20 in in IN cord-015021-pol2qm74 5248 21 each each DT cord-015021-pol2qm74 5248 22 of of IN cord-015021-pol2qm74 5248 23 these these DT cord-015021-pol2qm74 5248 24 groupings grouping NNS cord-015021-pol2qm74 5248 25 in in IN cord-015021-pol2qm74 5248 26 addition addition NN cord-015021-pol2qm74 5248 27 to to IN cord-015021-pol2qm74 5248 28 normal normal JJ cord-015021-pol2qm74 5248 29 blood blood NN cord-015021-pol2qm74 5248 30 donor donor NN cord-015021-pol2qm74 5248 31 controls control NNS cord-015021-pol2qm74 5248 32 . . . cord-015021-pol2qm74 5249 1 These these DT cord-015021-pol2qm74 5249 2 results result NNS cord-015021-pol2qm74 5249 3 show show VBP cord-015021-pol2qm74 5249 4 that that IN cord-015021-pol2qm74 5249 5 the the DT cord-015021-pol2qm74 5249 6 qualitative qualitative JJ cord-015021-pol2qm74 5249 7 C3 c3 NN cord-015021-pol2qm74 5249 8 , , , cord-015021-pol2qm74 5249 9 C4 C4 NNP cord-015021-pol2qm74 5249 10 and and CC cord-015021-pol2qm74 5249 11 the the DT cord-015021-pol2qm74 5249 12 functional functional JJ cord-015021-pol2qm74 5249 13 CHS0 CHS0 NNP cord-015021-pol2qm74 5249 14 complement complement NN cord-015021-pol2qm74 5249 15 assays assay NNS cord-015021-pol2qm74 5249 16 have have VBP cord-015021-pol2qm74 5249 17 good good JJ cord-015021-pol2qm74 5249 18 predictive predictive JJ cord-015021-pol2qm74 5249 19 values value NNS cord-015021-pol2qm74 5249 20 in in IN cord-015021-pol2qm74 5249 21 assessing assess VBG cord-015021-pol2qm74 5249 22 deteriorating deteriorate VBG cord-015021-pol2qm74 5249 23 liver liver NN cord-015021-pol2qm74 5249 24 function• function• JJ cord-015021-pol2qm74 5249 25 in in IN cord-015021-pol2qm74 5249 26 particular particular JJ cord-015021-pol2qm74 5249 27 , , , cord-015021-pol2qm74 5249 28 the the DT cord-015021-pol2qm74 5249 29 functional functional JJ cord-015021-pol2qm74 5249 30 assay assay NN cord-015021-pol2qm74 5249 31 for for IN cord-015021-pol2qm74 5249 32 complement complement NN cord-015021-pol2qm74 5249 33 ( ( -LRB- cord-015021-pol2qm74 5249 34 CH50 CH50 NNP cord-015021-pol2qm74 5249 35 ) ) -RRB- cord-015021-pol2qm74 5249 36 showed show VBD cord-015021-pol2qm74 5249 37 marked marked JJ cord-015021-pol2qm74 5249 38 impairment impairment NN cord-015021-pol2qm74 5249 39 in in IN cord-015021-pol2qm74 5249 40 Child child NN cord-015021-pol2qm74 5249 41 's 's POS cord-015021-pol2qm74 5249 42 C c NN cord-015021-pol2qm74 5249 43 patients patient NNS cord-015021-pol2qm74 5249 44 ( ( -LRB- cord-015021-pol2qm74 5249 45 p<0.000001 p<0.000001 NN cord-015021-pol2qm74 5249 46 ) ) -RRB- cord-015021-pol2qm74 5249 47 confirming confirm VBG cord-015021-pol2qm74 5249 48 the the DT cord-015021-pol2qm74 5249 49 impaired impair VBN cord-015021-pol2qm74 5249 50 immunological immunological JJ cord-015021-pol2qm74 5249 51 status status NN cord-015021-pol2qm74 5249 52 of of IN cord-015021-pol2qm74 5249 53 these these DT cord-015021-pol2qm74 5249 54 patients patient NNS cord-015021-pol2qm74 5249 55 . . . cord-015021-pol2qm74 5250 1 Sera Sera NNP cord-015021-pol2qm74 5250 2 from from IN cord-015021-pol2qm74 5250 3 this this DT cord-015021-pol2qm74 5250 4 group group NN cord-015021-pol2qm74 5250 5 of of IN cord-015021-pol2qm74 5250 6 patients patient NNS cord-015021-pol2qm74 5250 7 ( ( -LRB- cord-015021-pol2qm74 5250 8 Child child NN cord-015021-pol2qm74 5250 9 's 's POS cord-015021-pol2qm74 5250 10 C c NN cord-015021-pol2qm74 5250 11 ) ) -RRB- cord-015021-pol2qm74 5250 12 were be VBD cord-015021-pol2qm74 5250 13 titrated titrate VBN cord-015021-pol2qm74 5250 14 with with IN cord-015021-pol2qm74 5250 15 pig pig NN cord-015021-pol2qm74 5250 16 red red JJ cord-015021-pol2qm74 5250 17 blood blood NN cord-015021-pol2qm74 5250 18 cells cell NNS cord-015021-pol2qm74 5250 19 ( ( -LRB- cord-015021-pol2qm74 5250 20 RBCs rbc NNS cord-015021-pol2qm74 5250 21 ) ) -RRB- cord-015021-pol2qm74 5250 22 in in IN cord-015021-pol2qm74 5250 23 a a DT cord-015021-pol2qm74 5250 24 haemolytic haemolytic JJ cord-015021-pol2qm74 5250 25 assay assay NN cord-015021-pol2qm74 5250 26 . . . cord-015021-pol2qm74 5251 1 The the DT cord-015021-pol2qm74 5251 2 results result NNS cord-015021-pol2qm74 5251 3 showed show VBD cord-015021-pol2qm74 5251 4 that that IN cord-015021-pol2qm74 5251 5 there there EX cord-015021-pol2qm74 5251 6 were be VBD cord-015021-pol2qm74 5251 7 significantly significantly RB cord-015021-pol2qm74 5251 8 less less JJR cord-015021-pol2qm74 5251 9 haemolysis haemolysis NN cord-015021-pol2qm74 5251 10 of of IN cord-015021-pol2qm74 5251 11 pig pig NN cord-015021-pol2qm74 5251 12 RBCs rbc NNS cord-015021-pol2qm74 5251 13 in in IN cord-015021-pol2qm74 5251 14 these these DT cord-015021-pol2qm74 5251 15 patients patient NNS cord-015021-pol2qm74 5251 16 ( ( -LRB- cord-015021-pol2qm74 5251 17 p=0.0177 p=0.0177 NNP cord-015021-pol2qm74 5251 18 ) ) -RRB- cord-015021-pol2qm74 5251 19 as as IN cord-015021-pol2qm74 5251 20 compared compare VBN cord-015021-pol2qm74 5251 21 to to IN cord-015021-pol2qm74 5251 22 the the DT cord-015021-pol2qm74 5251 23 controls control NNS cord-015021-pol2qm74 5251 24 . . . cord-015021-pol2qm74 5252 1 This this DT cord-015021-pol2qm74 5252 2 findings finding NNS cord-015021-pol2qm74 5252 3 strongly strongly RB cord-015021-pol2qm74 5252 4 support support VBP cord-015021-pol2qm74 5252 5 an an DT cord-015021-pol2qm74 5252 6 impaired impaired JJ cord-015021-pol2qm74 5252 7 immunological immunological JJ cord-015021-pol2qm74 5252 8 status status NN cord-015021-pol2qm74 5252 9 in in IN cord-015021-pol2qm74 5252 10 Child child NN cord-015021-pol2qm74 5252 11 's 's POS cord-015021-pol2qm74 5252 12 C C NNP cord-015021-pol2qm74 5252 13 liver liver NN cord-015021-pol2qm74 5252 14 cirrhosis cirrhosis NN cord-015021-pol2qm74 5252 15 and and CC cord-015021-pol2qm74 5252 16 may may MD cord-015021-pol2qm74 5252 17 explain explain VB cord-015021-pol2qm74 5252 18 the the DT cord-015021-pol2qm74 5252 19 high high JJ cord-015021-pol2qm74 5252 20 incidence incidence NN cord-015021-pol2qm74 5252 21 of of IN cord-015021-pol2qm74 5252 22 sepsis sepsis NN cord-015021-pol2qm74 5252 23 as as IN cord-015021-pol2qm74 5252 24 a a DT cord-015021-pol2qm74 5252 25 terminal terminal JJ cord-015021-pol2qm74 5252 26 event event NN cord-015021-pol2qm74 5252 27 in in IN cord-015021-pol2qm74 5252 28 these these DT cord-015021-pol2qm74 5252 29 patients patient NNS cord-015021-pol2qm74 5252 30 . . . cord-015021-pol2qm74 5253 1 Aim aim VB cord-015021-pol2qm74 5253 2 : : : cord-015021-pol2qm74 5253 3 Kupffer Kupffer NNP cord-015021-pol2qm74 5253 4 cells(KC cells(kc NN cord-015021-pol2qm74 5253 5 ) ) -RRB- cord-015021-pol2qm74 5253 6 have have VB cord-015021-pol2qm74 5253 7 an an DT cord-015021-pol2qm74 5253 8 importamt importamt NN cord-015021-pol2qm74 5253 9 play play NN cord-015021-pol2qm74 5253 10 to to TO cord-015021-pol2qm74 5253 11 cause cause VB cord-015021-pol2qm74 5253 12 hepatocellular hepatocellular JJ cord-015021-pol2qm74 5253 13 injury injury NN cord-015021-pol2qm74 5253 14 in in IN cord-015021-pol2qm74 5253 15 sepsis sepsis NN cord-015021-pol2qm74 5253 16 , , , cord-015021-pol2qm74 5253 17 because because IN cord-015021-pol2qm74 5253 18 these these DT cord-015021-pol2qm74 5253 19 cells cell NNS cord-015021-pol2qm74 5253 20 release release VBP cord-015021-pol2qm74 5253 21 many many JJ cord-015021-pol2qm74 5253 22 kinds kind NNS cord-015021-pol2qm74 5253 23 of of IN cord-015021-pol2qm74 5253 24 substances substance NNS cord-015021-pol2qm74 5253 25 . . . cord-015021-pol2qm74 5254 1 We -PRON- PRP cord-015021-pol2qm74 5254 2 reported report VBD cord-015021-pol2qm74 5254 3 that that IN cord-015021-pol2qm74 5254 4 oxygem oxygem NNP cord-015021-pol2qm74 5254 5 radicals radical NNS cord-015021-pol2qm74 5254 6 released release VBN cord-015021-pol2qm74 5254 7 by by IN cord-015021-pol2qm74 5254 8 KCs kc NNS cord-015021-pol2qm74 5254 9 stimulated stimulate VBN cord-015021-pol2qm74 5254 10 by by IN cord-015021-pol2qm74 5254 11 lipopolysaccharide lipopolysaccharide NN cord-015021-pol2qm74 5254 12 ( ( -LRB- cord-015021-pol2qm74 5254 13 LPS LPS NNP cord-015021-pol2qm74 5254 14 ) ) -RRB- cord-015021-pol2qm74 5254 15 caused cause VBD cord-015021-pol2qm74 5254 16 hepatocellular hepatocellular JJ cord-015021-pol2qm74 5254 17 injury injury NN cord-015021-pol2qm74 5254 18 . . . cord-015021-pol2qm74 5255 1 Aim aim VB cord-015021-pol2qm74 5255 2 of of IN cord-015021-pol2qm74 5255 3 this this DT cord-015021-pol2qm74 5255 4 study study NN cord-015021-pol2qm74 5255 5 is be VBZ cord-015021-pol2qm74 5255 6 to to TO cord-015021-pol2qm74 5255 7 investigate investigate VB cord-015021-pol2qm74 5255 8 the the DT cord-015021-pol2qm74 5255 9 relationship relationship NN cord-015021-pol2qm74 5255 10 between between IN cord-015021-pol2qm74 5255 11 imtracellmlar imtracellmlar NNP cord-015021-pol2qm74 5255 12 calcium(Ca calcium(ca NN cord-015021-pol2qm74 5255 13 ) ) -RRB- cord-015021-pol2qm74 5255 14 concentration concentration NN cord-015021-pol2qm74 5255 15 of of IN cord-015021-pol2qm74 5255 16 cultured cultured JJ cord-015021-pol2qm74 5255 17 rat rat NN cord-015021-pol2qm74 5255 18 KCs kc NNS cord-015021-pol2qm74 5255 19 stimulated stimulate VBN cord-015021-pol2qm74 5255 20 by by IN cord-015021-pol2qm74 5255 21 LPS LPS NNP cord-015021-pol2qm74 5255 22 and and CC cord-015021-pol2qm74 5255 23 release release NN cord-015021-pol2qm74 5255 24 of of IN cord-015021-pol2qm74 5255 25 oxygen oxygen NN cord-015021-pol2qm74 5255 26 radicals radical NNS cord-015021-pol2qm74 5255 27 , , , cord-015021-pol2qm74 5255 28 and and CC cord-015021-pol2qm74 5255 29 effect effect NN cord-015021-pol2qm74 5255 30 of of IN cord-015021-pol2qm74 5255 31 prostaglandin prostaglandin NN cord-015021-pol2qm74 5255 32 E~ E~ NNS cord-015021-pol2qm74 5255 33 ( ( -LRB- cord-015021-pol2qm74 5255 34 PGE~ PGE~ NNP cord-015021-pol2qm74 5255 35 ) ) -RRB- cord-015021-pol2qm74 5255 36 on on IN cord-015021-pol2qm74 5255 37 imtracellular imtracellular NNP cord-015021-pol2qm74 5256 1 Ca ca RB cord-015021-pol2qm74 5256 2 concentration concentration NN cord-015021-pol2qm74 5256 3 . . . cord-015021-pol2qm74 5257 1 Production production NN cord-015021-pol2qm74 5257 2 of of IN cord-015021-pol2qm74 5257 3 acute acute JJ cord-015021-pol2qm74 5257 4 phase phase NN cord-015021-pol2qm74 5257 5 proteins protein NNS cord-015021-pol2qm74 5257 6 ( ( -LRB- cord-015021-pol2qm74 5257 7 C c NN cord-015021-pol2qm74 5257 8 - - HYPH cord-015021-pol2qm74 5257 9 reactive reactive JJ cord-015021-pol2qm74 5257 10 protein protein NN cord-015021-pol2qm74 5257 11 , , , cord-015021-pol2qm74 5257 12 CRP CRP NNP cord-015021-pol2qm74 5257 13 , , , cord-015021-pol2qm74 5257 14 transferrin transferrin NN cord-015021-pol2qm74 5257 15 , , , cord-015021-pol2qm74 5257 16 Tf Tf NNP cord-015021-pol2qm74 5257 17 ) ) -RRB- cord-015021-pol2qm74 5257 18 and and CC cord-015021-pol2qm74 5257 19 £ £ $ cord-015021-pol2qm74 5257 20 erritin erritin NNS cord-015021-pol2qm74 5257 21 ( ( -LRB- cord-015021-pol2qm74 5257 22 F F NNP cord-015021-pol2qm74 5257 23 ) ) -RRB- cord-015021-pol2qm74 5257 24 in in IN cord-015021-pol2qm74 5257 25 rat rat NN cord-015021-pol2qm74 5257 26 hepatocytes hepatocyte NNS cord-015021-pol2qm74 5257 27 ( ( -LRB- cord-015021-pol2qm74 5257 28 Hps Hps NNP cord-015021-pol2qm74 5257 29 ) ) -RRB- cord-015021-pol2qm74 5257 30 and and CC cord-015021-pol2qm74 5257 31 its -PRON- PRP$ cord-015021-pol2qm74 5257 32 dependence dependence NN cord-015021-pol2qm74 5257 33 on on IN cord-015021-pol2qm74 5257 34 extracellular extracellular JJ cord-015021-pol2qm74 5257 35 matrix matrix NN cord-015021-pol2qm74 5257 36 components component NNS cord-015021-pol2qm74 5257 37 were be VBD cord-015021-pol2qm74 5257 38 studied study VBN cord-015021-pol2qm74 5257 39 . . . cord-015021-pol2qm74 5258 1 Hps Hps NNP cord-015021-pol2qm74 5258 2 isolated isolate VBN cord-015021-pol2qm74 5258 3 from from IN cord-015021-pol2qm74 5258 4 the the DT cord-015021-pol2qm74 5258 5 liver liver NN cord-015021-pol2qm74 5258 6 by by IN cord-015021-pol2qm74 5258 7 collagenase collagenase NNP cord-015021-pol2qm74 5258 8 perfusion perfusion NN cord-015021-pol2qm74 5258 9 were be VBD cord-015021-pol2qm74 5258 10 cultured culture VBN cord-015021-pol2qm74 5258 11 at at IN cord-015021-pol2qm74 5258 12 ~O5 ~o5 CD cord-015021-pol2qm74 5258 13 per per IN cord-015021-pol2qm74 5258 14 0.5 0.5 CD cord-015021-pol2qm74 5258 15 ml ml NN cord-015021-pol2qm74 5258 16 medium medium JJ cord-015021-pol2qm74 5258 17 FI2+DMEM fi2+dmem NN cord-015021-pol2qm74 5259 1 ( ( -LRB- cord-015021-pol2qm74 5259 2 1:1 1:1 LS cord-015021-pol2qm74 5259 3 ) ) -RRB- cord-015021-pol2qm74 5259 4 with with IN cord-015021-pol2qm74 5259 5 10 10 CD cord-015021-pol2qm74 5259 6 % % NN cord-015021-pol2qm74 5259 7 fetal fetal JJ cord-015021-pol2qm74 5259 8 calf calf NN cord-015021-pol2qm74 5259 9 serum serum NN cord-015021-pol2qm74 5259 10 for for IN cord-015021-pol2qm74 5259 11 2 2 CD cord-015021-pol2qm74 5259 12 days day NNS cord-015021-pol2qm74 5259 13 on on IN cord-015021-pol2qm74 5259 14 uncoated uncoated JJ cord-015021-pol2qm74 5259 15 or or CC cord-015021-pol2qm74 5259 16 type type NN cord-015021-pol2qm74 5260 1 I -PRON- PRP cord-015021-pol2qm74 5260 2 collagen collagen NN cord-015021-pol2qm74 5260 3 coated coat VBN cord-015021-pol2qm74 5260 4 plastic plastic NN cord-015021-pol2qm74 5260 5 surface surface NN cord-015021-pol2qm74 5260 6 or or CC cord-015021-pol2qm74 5260 7 in in IN cord-015021-pol2qm74 5260 8 the the DT cord-015021-pol2qm74 5260 9 presence presence NN cord-015021-pol2qm74 5260 10 of of IN cord-015021-pol2qm74 5260 11 dextrane dextrane NNP cord-015021-pol2qm74 5260 12 sulphate sulphate NN cord-015021-pol2qm74 5260 13 in in IN cord-015021-pol2qm74 5260 14 the the DT cord-015021-pol2qm74 5260 15 medium medium NN cord-015021-pol2qm74 5260 16 . . . cord-015021-pol2qm74 5261 1 Hps Hps NNP cord-015021-pol2qm74 5261 2 were be VBD cord-015021-pol2qm74 5261 3 stimulated stimulate VBN cord-015021-pol2qm74 5261 4 by by IN cord-015021-pol2qm74 5261 5 conditioned condition VBN cord-015021-pol2qm74 5261 6 medium medium NN cord-015021-pol2qm74 5261 7 ( ( -LRB- cord-015021-pol2qm74 5261 8 GM GM NNP cord-015021-pol2qm74 5261 9 ) ) -RRB- cord-015021-pol2qm74 5261 10 from from IN cord-015021-pol2qm74 5261 11 I I NNP cord-015021-pol2qm74 5261 12 ~ ~ CD cord-015021-pol2qm74 5261 13 IA IA NNP cord-015021-pol2qm74 5261 14 - - HYPH cord-015021-pol2qm74 5261 15 P P NNP cord-015021-pol2qm74 5261 16 or or CC cord-015021-pol2qm74 5261 17 E. E. NNP cord-015021-pol2qm74 5261 18 coli coli VBZ cord-015021-pol2qm74 5261 19 LPS LPS NNP cord-015021-pol2qm74 5261 20 preineubated preineubate VBD cord-015021-pol2qm74 5261 21 human human JJ cord-015021-pol2qm74 5261 22 blood blood NN cord-015021-pol2qm74 5261 23 mononuclear mononuclear NN cord-015021-pol2qm74 5261 24 cells cell NNS cord-015021-pol2qm74 5261 25 . . . cord-015021-pol2qm74 5262 1 Production production NN cord-015021-pol2qm74 5262 2 of of IN cord-015021-pol2qm74 5262 3 CRP CRP NNP cord-015021-pol2qm74 5262 4 , , , cord-015021-pol2qm74 5262 5 Tf Tf NNP cord-015021-pol2qm74 5262 6 and and CC cord-015021-pol2qm74 5262 7 F F NNP cord-015021-pol2qm74 5262 8 by by IN cord-015021-pol2qm74 5262 9 Hps Hps NNP cord-015021-pol2qm74 5262 10 was be VBD cord-015021-pol2qm74 5262 11 detected detect VBN cord-015021-pol2qm74 5262 12 by by IN cord-015021-pol2qm74 5262 13 ELiSA ELiSA NNP cord-015021-pol2qm74 5262 14 . . . cord-015021-pol2qm74 5263 1 It -PRON- PRP cord-015021-pol2qm74 5263 2 was be VBD cord-015021-pol2qm74 5263 3 found find VBN cord-015021-pol2qm74 5263 4 that that IN cord-015021-pol2qm74 5263 5 both both DT cord-015021-pol2qm74 5263 6 CMs cm NNS cord-015021-pol2qm74 5263 7 decreased decrease VBD cord-015021-pol2qm74 5263 8 Tf Tf NNP cord-015021-pol2qm74 5263 9 synthesis synthesis NN cord-015021-pol2qm74 5263 10 in in IN cord-015021-pol2qm74 5263 11 Hps Hps NNP cord-015021-pol2qm74 5263 12 by by IN cord-015021-pol2qm74 5263 13 15 15 CD cord-015021-pol2qm74 5263 14 - - SYM cord-015021-pol2qm74 5263 15 50 50 CD cord-015021-pol2qm74 5263 16 % % NN cord-015021-pol2qm74 5263 17 ( ( -LRB- cord-015021-pol2qm74 5263 18 p p NN cord-015021-pol2qm74 5263 19 < < XX cord-015021-pol2qm74 5263 20 O.OS O.OS NNP cord-015021-pol2qm74 5263 21 ) ) -RRB- cord-015021-pol2qm74 5263 22 . . . cord-015021-pol2qm74 5264 1 The the DT cord-015021-pol2qm74 5264 2 level level NN cord-015021-pol2qm74 5264 3 of of IN cord-015021-pol2qm74 5264 4 F F NNP cord-015021-pol2qm74 5264 5 synthesis synthesis NN cord-015021-pol2qm74 5264 6 did do VBD cord-015021-pol2qm74 5264 7 n't not RB cord-015021-pol2qm74 5264 8 change change VB cord-015021-pol2qm74 5264 9 or or CC cord-015021-pol2qm74 5264 10 only only RB cord-015021-pol2qm74 5264 11 slightly slightly RB cord-015021-pol2qm74 5264 12 decreased decrease VBD cord-015021-pol2qm74 5264 13 . . . cord-015021-pol2qm74 5265 1 The the DT cord-015021-pol2qm74 5265 2 addition addition NN cord-015021-pol2qm74 5265 3 of of IN cord-015021-pol2qm74 5265 4 CMs cms NN cord-015021-pol2qm74 5265 5 led lead VBD cord-015021-pol2qm74 5265 6 to to IN cord-015021-pol2qm74 5265 7 the the DT cord-015021-pol2qm74 5265 8 enhancement enhancement NN cord-015021-pol2qm74 5265 9 of of IN cord-015021-pol2qm74 5265 10 CRP crp NN cord-015021-pol2qm74 5265 11 synthesis synthesis NN cord-015021-pol2qm74 5265 12 more more JJR cord-015021-pol2qm74 5265 13 than than IN cord-015021-pol2qm74 5265 14 2.5 2.5 CD cord-015021-pol2qm74 5265 15 times time NNS cord-015021-pol2qm74 5265 16 . . . cord-015021-pol2qm74 5266 1 The the DT cord-015021-pol2qm74 5266 2 most most RBS cord-015021-pol2qm74 5266 3 reproducible reproducible JJ cord-015021-pol2qm74 5266 4 results result NNS cord-015021-pol2qm74 5266 5 were be VBD cord-015021-pol2qm74 5266 6 obtained obtain VBN cord-015021-pol2qm74 5266 7 when when WRB cord-015021-pol2qm74 5266 8 plastics plastic NNS cord-015021-pol2qm74 5266 9 had have VBD cord-015021-pol2qm74 5266 10 been be VBN cord-015021-pol2qm74 5266 11 coated coat VBN cord-015021-pol2qm74 5266 12 with with IN cord-015021-pol2qm74 5266 13 collagen collagen NN cord-015021-pol2qm74 5266 14 . . . cord-015021-pol2qm74 5267 1 Dextran dextran NN cord-015021-pol2qm74 5267 2 sulphate sulphate NN cord-015021-pol2qm74 5267 3 markedly markedly RB cord-015021-pol2qm74 5267 4 increased increase VBD cord-015021-pol2qm74 5267 5 CRP crp NN cord-015021-pol2qm74 5267 6 synthesis synthesis NN cord-015021-pol2qm74 5267 7 . . . cord-015021-pol2qm74 5268 1 Thus thus RB cord-015021-pol2qm74 5268 2 using use VBG cord-015021-pol2qm74 5268 3 this this DT cord-015021-pol2qm74 5268 4 model model NN cord-015021-pol2qm74 5268 5 of of IN cord-015021-pol2qm74 5268 6 an an DT cord-015021-pol2qm74 5268 7 acute acute JJ cord-015021-pol2qm74 5268 8 phase phase NN cord-015021-pol2qm74 5268 9 reaction reaction NN cord-015021-pol2qm74 5268 10 in in IN cord-015021-pol2qm74 5268 11 vitro vitro FW cord-015021-pol2qm74 5268 12 we -PRON- PRP cord-015021-pol2qm74 5268 13 found find VBD cord-015021-pol2qm74 5268 14 the the DT cord-015021-pol2qm74 5268 15 enhancement enhancement NN cord-015021-pol2qm74 5268 16 of of IN cord-015021-pol2qm74 5268 17 CRP crp NN cord-015021-pol2qm74 5268 18 synthesis synthesis NN cord-015021-pol2qm74 5268 19 and and CC cord-015021-pol2qm74 5268 20 the the DT cord-015021-pol2qm74 5268 21 decrease decrease NN cord-015021-pol2qm74 5268 22 of of IN cord-015021-pol2qm74 5268 23 Tf Tf NNP cord-015021-pol2qm74 5268 24 synthesis synthesis NN cord-015021-pol2qm74 5268 25 . . . cord-015021-pol2qm74 5269 1 Our -PRON- PRP$ cord-015021-pol2qm74 5269 2 data datum NNS cord-015021-pol2qm74 5269 3 correspond correspond VBP cord-015021-pol2qm74 5269 4 with with IN cord-015021-pol2qm74 5269 5 nublished nublished JJ cord-015021-pol2qm74 5269 6 materials material NNS cord-015021-pol2qm74 5269 7 on on IN cord-015021-pol2qm74 5269 8 the the DT cord-015021-pol2qm74 5269 9 acute acute JJ cord-015021-pol2qm74 5269 10 phase phase NN cord-015021-pol2qm74 5269 11 in in IN cord-015021-pol2qm74 5269 12 vivo vivo NN cord-015021-pol2qm74 5269 13 and and CC cord-015021-pol2qm74 5269 14 point point NN cord-015021-pol2qm74 5269 15 to to IN cord-015021-pol2qm74 5269 16 relevance relevance NN cord-015021-pol2qm74 5269 17 of of IN cord-015021-pol2qm74 5269 18 the the DT cord-015021-pol2qm74 5269 19 proposed propose VBN cord-015021-pol2qm74 5269 20 model model NN cord-015021-pol2qm74 5269 21 . . . cord-015021-pol2qm74 5270 1 Metabolism metabolism NN cord-015021-pol2qm74 5270 2 of of IN cord-015021-pol2qm74 5270 3 hepatocytes hepatocyte NNS cord-015021-pol2qm74 5270 4 under under IN cord-015021-pol2qm74 5270 5 traumatic traumatic JJ cord-015021-pol2qm74 5270 6 illness illness NN cord-015021-pol2qm74 5270 7 has have VBZ cord-015021-pol2qm74 5270 8 not not RB cord-015021-pol2qm74 5270 9 been be VBN cord-015021-pol2qm74 5270 10 sufficiently sufficiently RB cord-015021-pol2qm74 5270 11 investigated investigate VBN cord-015021-pol2qm74 5270 12 . . . cord-015021-pol2qm74 5271 1 Therefore therefore RB cord-015021-pol2qm74 5271 2 we -PRON- PRP cord-015021-pol2qm74 5271 3 have have VBP cord-015021-pol2qm74 5271 4 applied apply VBN cord-015021-pol2qm74 5271 5 absorption absorption NN cord-015021-pol2qm74 5271 6 and and CC cord-015021-pol2qm74 5271 7 fluorescent fluorescent JJ cord-015021-pol2qm74 5271 8 cytophotometry cytophotometry NN cord-015021-pol2qm74 5271 9 techniques technique NNS cord-015021-pol2qm74 5271 10 to to TO cord-015021-pol2qm74 5271 11 study study VB cord-015021-pol2qm74 5271 12 the the DT cord-015021-pol2qm74 5271 13 content content NN cord-015021-pol2qm74 5271 14 of of IN cord-015021-pol2qm74 5271 15 RNA RNA NNP cord-015021-pol2qm74 5271 16 , , , cord-015021-pol2qm74 5271 17 glycogen glycogen NNP cord-015021-pol2qm74 5271 18 and and CC cord-015021-pol2qm74 5271 19 its -PRON- PRP$ cord-015021-pol2qm74 5271 20 fractions fraction NNS cord-015021-pol2qm74 5271 21 in in IN cord-015021-pol2qm74 5271 22 hepatocytes hepatocyte NNS cord-015021-pol2qm74 5271 23 of of IN cord-015021-pol2qm74 5271 24 patients patient NNS cord-015021-pol2qm74 5271 25 with with IN cord-015021-pol2qm74 5271 26 severe severe JJ cord-015021-pol2qm74 5271 27 mechanical mechanical JJ cord-015021-pol2qm74 5271 28 trauma trauma NN cord-015021-pol2qm74 5271 29 , , , cord-015021-pol2qm74 5271 30 both both CC cord-015021-pol2qm74 5271 31 with with IN cord-015021-pol2qm74 5271 32 and and CC cord-015021-pol2qm74 5271 33 without without IN cord-015021-pol2qm74 5271 34 endointoxication endointoxication NN cord-015021-pol2qm74 5271 35 at at IN cord-015021-pol2qm74 5271 36 various various JJ cord-015021-pol2qm74 5271 37 stages stage NNS cord-015021-pol2qm74 5271 38 . . . cord-015021-pol2qm74 5272 1 For for IN cord-015021-pol2qm74 5272 2 these these DT cord-015021-pol2qm74 5272 3 purposes purpose NNS cord-015021-pol2qm74 5272 4 slides slide NNS cord-015021-pol2qm74 5272 5 were be VBD cord-015021-pol2qm74 5272 6 prepared prepare VBN cord-015021-pol2qm74 5272 7 from from IN cord-015021-pol2qm74 5272 8 the the DT cord-015021-pol2qm74 5272 9 repeated repeat VBN cord-015021-pol2qm74 5272 10 aspiration aspiration NN cord-015021-pol2qm74 5272 11 biopsy biopsy NN cord-015021-pol2qm74 5272 12 material material NN cord-015021-pol2qm74 5272 13 according accord VBG cord-015021-pol2qm74 5272 14 to to IN cord-015021-pol2qm74 5272 15 special special JJ cord-015021-pol2qm74 5272 16 techniques technique NNS cord-015021-pol2qm74 5272 17 ( ( -LRB- cord-015021-pol2qm74 5272 18 Kudryavtseva Kudryavtseva NNP cord-015021-pol2qm74 5272 19 et et NNP cord-015021-pol2qm74 5272 20 al al NNP cord-015021-pol2qm74 5272 21 . . NNP cord-015021-pol2qm74 5272 22 , , , cord-015021-pol2qm74 5272 23 1983 1983 CD cord-015021-pol2qm74 5272 24 ) ) -RRB- cord-015021-pol2qm74 5272 25 . . . cord-015021-pol2qm74 5273 1 Slides slide NNS cord-015021-pol2qm74 5273 2 were be VBD cord-015021-pol2qm74 5273 3 stained stain VBN cord-015021-pol2qm74 5273 4 by by IN cord-015021-pol2qm74 5273 5 gallocyanin gallocyanin NN cord-015021-pol2qm74 5273 6 - - HYPH cord-015021-pol2qm74 5273 7 chromalum chromalum NN cord-015021-pol2qm74 5273 8 to to TO cord-015021-pol2qm74 5273 9 measure measure VB cord-015021-pol2qm74 5273 10 RNA RNA NNP cord-015021-pol2qm74 5273 11 or or CC cord-015021-pol2qm74 5273 12 underwent undergo VBD cord-015021-pol2qm74 5273 13 fluorescent fluorescent JJ cord-015021-pol2qm74 5273 14 PAS pas NN cord-015021-pol2qm74 5273 15 - - HYPH cord-015021-pol2qm74 5273 16 reaction reaction NN cord-015021-pol2qm74 5273 17 to to TO cord-015021-pol2qm74 5273 18 measure measure VB cord-015021-pol2qm74 5273 19 glycogen glycogen NN cord-015021-pol2qm74 5273 20 and and CC cord-015021-pol2qm74 5273 21 its -PRON- PRP$ cord-015021-pol2qm74 5273 22 fractions fraction NNS cord-015021-pol2qm74 5273 23 ( ( -LRB- cord-015021-pol2qm74 5273 24 Kudryavtseva Kudryavtseva NNP cord-015021-pol2qm74 5273 25 et et NNP cord-015021-pol2qm74 5273 26 al al NNP cord-015021-pol2qm74 5273 27 . . NNP cord-015021-pol2qm74 5273 28 , , , cord-015021-pol2qm74 5273 29 1970 1970 CD cord-015021-pol2qm74 5274 1 ( ( -LRB- cord-015021-pol2qm74 5274 2 Kudryavtseva Kudryavtseva NNP cord-015021-pol2qm74 5274 3 et et NNP cord-015021-pol2qm74 5274 4 al al NNP cord-015021-pol2qm74 5274 5 . . . cord-015021-pol2qm74 5275 1 , , , cord-015021-pol2qm74 5275 2 , , , cord-015021-pol2qm74 5275 3 1974 1974 CD cord-015021-pol2qm74 5275 4 _SP cord-015021-pol2qm74 5276 1 The the DT cord-015021-pol2qm74 5276 2 ability ability NN cord-015021-pol2qm74 5276 3 of of IN cord-015021-pol2qm74 5276 4 02 02 CD cord-015021-pol2qm74 5276 5 metabolites metabolite NNS cord-015021-pol2qm74 5276 6 derived derive VBN cord-015021-pol2qm74 5276 7 from from IN cord-015021-pol2qm74 5276 8 the the DT cord-015021-pol2qm74 5276 9 xanthine xanthine NN cord-015021-pol2qm74 5276 10 - - HYPH cord-015021-pol2qm74 5276 11 xanthine xanthine NN cord-015021-pol2qm74 5276 12 oxidase oxidase NN cord-015021-pol2qm74 5276 13 system system NN cord-015021-pol2qm74 5276 14 to to TO cord-015021-pol2qm74 5276 15 inhibit inhibit VB cord-015021-pol2qm74 5276 16 mitochondrial mitochondrial JJ cord-015021-pol2qm74 5276 17 function function NN cord-015021-pol2qm74 5276 18 was be VBD cord-015021-pol2qm74 5276 19 examined examine VBN cord-015021-pol2qm74 5276 20 using use VBG cord-015021-pol2qm74 5276 21 freshly freshly RB cord-015021-pol2qm74 5276 22 isolated isolate VBN cord-015021-pol2qm74 5276 23 rat rat NN cord-015021-pol2qm74 5276 24 liver liver NN cord-015021-pol2qm74 5276 25 mitochondria mitochondrion NNS cord-015021-pol2qm74 5276 26 . . . cord-015021-pol2qm74 5277 1 Under under IN cord-015021-pol2qm74 5277 2 uncoupled uncoupled JJ cord-015021-pol2qm74 5277 3 conditions condition NNS cord-015021-pol2qm74 5277 4 , , , cord-015021-pol2qm74 5277 5 mitochondria mitochondrion NNS cord-015021-pol2qm74 5277 6 exposed expose VBN cord-015021-pol2qm74 5277 7 to to IN cord-015021-pol2qm74 5277 8 free free JJ cord-015021-pol2qm74 5277 9 radicals radical NNS cord-015021-pol2qm74 5277 10 exhibited exhibit VBD cord-015021-pol2qm74 5277 11 a a DT cord-015021-pol2qm74 5277 12 significant significant JJ cord-015021-pol2qm74 5277 13 decrease decrease NN cord-015021-pol2qm74 5277 14 in in IN cord-015021-pol2qm74 5277 15 02 02 CD cord-015021-pol2qm74 5277 16 consumption consumption NN cord-015021-pol2qm74 5277 17 supported support VBN cord-015021-pol2qm74 5277 18 by by IN cord-015021-pol2qm74 5277 19 NAD+-Iinked nad+-iinked JJ cord-015021-pol2qm74 5277 20 substrates substrate NNS cord-015021-pol2qm74 5277 21 , , , cord-015021-pol2qm74 5277 22 but but CC cord-015021-pol2qm74 5277 23 showed show VBD cord-015021-pol2qm74 5277 24 almost almost RB cord-015021-pol2qm74 5277 25 no no DT cord-015021-pol2qm74 5277 26 change change NN cord-015021-pol2qm74 5277 27 in in IN cord-015021-pol2qm74 5277 28 02 02 CD cord-015021-pol2qm74 5277 29 consumption consumption NN cord-015021-pol2qm74 5277 30 in in IN cord-015021-pol2qm74 5277 31 the the DT cord-015021-pol2qm74 5277 32 presence presence NN cord-015021-pol2qm74 5277 33 of of IN cord-015021-pol2qm74 5277 34 succinate succinate NNP cord-015021-pol2qm74 5277 35 and and CC cord-015021-pol2qm74 5277 36 ascorbate ascorbate NN cord-015021-pol2qm74 5277 37 . . . cord-015021-pol2qm74 5278 1 The the DT cord-015021-pol2qm74 5278 2 activity activity NN cord-015021-pol2qm74 5278 3 of of IN cord-015021-pol2qm74 5278 4 electron electron NN cord-015021-pol2qm74 5278 5 transfer transfer NN cord-015021-pol2qm74 5278 6 complex complex NN cord-015021-pol2qm74 5278 7 I i NN cord-015021-pol2qm74 5278 8 ( ( -LRB- cord-015021-pol2qm74 5278 9 NADH NADH NNP cord-015021-pol2qm74 5278 10 oxidase oxidase NN cord-015021-pol2qm74 5278 11 and and CC cord-015021-pol2qm74 5278 12 NADH NADH NNP cord-015021-pol2qm74 5278 13 - - HYPH cord-015021-pol2qm74 5278 14 cytochrome cytochrome NNP cord-015021-pol2qm74 5278 15 c c NN cord-015021-pol2qm74 5278 16 oxidoreductase oxidoreductase NN cord-015021-pol2qm74 5278 17 ) ) -RRB- cord-015021-pol2qm74 5278 18 and and CC cord-015021-pol2qm74 5278 19 the the DT cord-015021-pol2qm74 5278 20 energy energy NN cord-015021-pol2qm74 5278 21 - - HYPH cord-015021-pol2qm74 5278 22 dependent dependent JJ cord-015021-pol2qm74 5278 23 reduction reduction NN cord-015021-pol2qm74 5278 24 of of IN cord-015021-pol2qm74 5278 25 NAD+ NAD+ NNP cord-015021-pol2qm74 5278 26 by by IN cord-015021-pol2qm74 5278 27 succinate succinate NNP cord-015021-pol2qm74 5278 28 were be VBD cord-015021-pol2qm74 5278 29 unaltered unaltered JJ cord-015021-pol2qm74 5278 30 by by IN cord-015021-pol2qm74 5278 31 oxidative oxidative JJ cord-015021-pol2qm74 5278 32 stress stress NN cord-015021-pol2qm74 5278 33 . . . cord-015021-pol2qm74 5279 1 Exposure exposure NN cord-015021-pol2qm74 5279 2 to to TO cord-015021-pol2qm74 5279 3 free free JJ cord-015021-pol2qm74 5279 4 radicals radical NNS cord-015021-pol2qm74 5279 5 also also RB cord-015021-pol2qm74 5279 6 had have VBD cord-015021-pol2qm74 5279 7 an an DT cord-015021-pol2qm74 5279 8 uncoupling uncoupling JJ cord-015021-pol2qm74 5279 9 effect effect NN cord-015021-pol2qm74 5279 10 at at IN cord-015021-pol2qm74 5279 11 all all RB cord-015021-pol2qm74 5279 12 three three CD cord-015021-pol2qm74 5279 13 coupling coupling NN cord-015021-pol2qm74 5279 14 sites site NNS cord-015021-pol2qm74 5279 15 . . . cord-015021-pol2qm74 5280 1 The the DT cord-015021-pol2qm74 5280 2 degree degree NN cord-015021-pol2qm74 5280 3 of of IN cord-015021-pol2qm74 5280 4 mitochondrial mitochondrial JJ cord-015021-pol2qm74 5280 5 swelling swelling NN cord-015021-pol2qm74 5280 6 was be VBD cord-015021-pol2qm74 5280 7 closely closely RB cord-015021-pol2qm74 5280 8 correlated correlate VBN cord-015021-pol2qm74 5280 9 with with IN cord-015021-pol2qm74 5280 10 the the DT cord-015021-pol2qm74 5280 11 inhibition inhibition NN cord-015021-pol2qm74 5280 12 of of IN cord-015021-pol2qm74 5280 13 state state NN cord-015021-pol2qm74 5280 14 3 3 CD cord-015021-pol2qm74 5280 15 oxidation oxidation NN cord-015021-pol2qm74 5280 16 of of IN cord-015021-pol2qm74 5280 17 site site NN cord-015021-pol2qm74 5280 18 I -PRON- PRP cord-015021-pol2qm74 5280 19 substrates substrate NNS cord-015021-pol2qm74 5280 20 and and CC cord-015021-pol2qm74 5280 21 with with IN cord-015021-pol2qm74 5280 22 the the DT cord-015021-pol2qm74 5280 23 increase increase NN cord-015021-pol2qm74 5280 24 in in IN cord-015021-pol2qm74 5280 25 state state NN cord-015021-pol2qm74 5280 26 4 4 CD cord-015021-pol2qm74 5280 27 oxidation oxidation NN cord-015021-pol2qm74 5280 28 of of IN cord-015021-pol2qm74 5280 29 succinate succinate NN cord-015021-pol2qm74 5280 30 . . . cord-015021-pol2qm74 5281 1 The the DT cord-015021-pol2qm74 5281 2 immunosuppressive immunosuppressive JJ cord-015021-pol2qm74 5281 3 agent agent NN cord-015021-pol2qm74 5281 4 cyclosporin cyclosporin NN cord-015021-pol2qm74 5281 5 A A NNP cord-015021-pol2qm74 5281 6 ( ( -LRB- cord-015021-pol2qm74 5281 7 CyA cya NN cord-015021-pol2qm74 5281 8 ) ) -RRB- cord-015021-pol2qm74 5281 9 completely completely RB cord-015021-pol2qm74 5281 10 prevented prevent VBD cord-015021-pol2qm74 5281 11 the the DT cord-015021-pol2qm74 5281 12 mitochondrial mitochondrial JJ cord-015021-pol2qm74 5281 13 damage damage NN cord-015021-pol2qm74 5281 14 induced induce VBN cord-015021-pol2qm74 5281 15 by by IN cord-015021-pol2qm74 5281 16 oxygen oxygen NN cord-015021-pol2qm74 5281 17 free free JJ cord-015021-pol2qm74 5281 18 radicals radical NNS cord-015021-pol2qm74 5281 19 ( ( -LRB- cord-015021-pol2qm74 5281 20 swelling swell VBG cord-015021-pol2qm74 5281 21 , , , cord-015021-pol2qm74 5281 22 Ca2 Ca2 NNP cord-015021-pol2qm74 5281 23 + + CC cord-015021-pol2qm74 5281 24 release release NN cord-015021-pol2qm74 5281 25 , , , cord-015021-pol2qm74 5281 26 sucrose sucrose NN cord-015021-pol2qm74 5281 27 trapping trapping NN cord-015021-pol2qm74 5281 28 , , , cord-015021-pol2qm74 5281 29 uncoupling uncoupling NN cord-015021-pol2qm74 5281 30 , , , cord-015021-pol2qm74 5281 31 and and CC cord-015021-pol2qm74 5281 32 selective selective JJ cord-015021-pol2qm74 5281 33 inhibition inhibition NN cord-015021-pol2qm74 5281 34 of of IN cord-015021-pol2qm74 5281 35 the the DT cord-015021-pol2qm74 5281 36 mitochondrial mitochondrial JJ cord-015021-pol2qm74 5281 37 respiration respiration NN cord-015021-pol2qm74 5281 38 of of IN cord-015021-pol2qm74 5281 39 site site NN cord-015021-pol2qm74 5281 40 I -PRON- PRP cord-015021-pol2qm74 5281 41 substrates substrate NNS cord-015021-pol2qm74 5281 42 ) ) -RRB- cord-015021-pol2qm74 5281 43 . . . cord-015021-pol2qm74 5282 1 The the DT cord-015021-pol2qm74 5282 2 same same JJ cord-015021-pol2qm74 5282 3 protective protective JJ cord-015021-pol2qm74 5282 4 effect effect NN cord-015021-pol2qm74 5282 5 was be VBD cord-015021-pol2qm74 5282 6 found find VBN cord-015021-pol2qm74 5282 7 when when WRB cord-015021-pol2qm74 5282 8 Ca2 Ca2 NNP cord-015021-pol2qm74 5282 9 + + CC cord-015021-pol2qm74 5282 10 cycling cycling NN cord-015021-pol2qm74 5282 11 was be VBD cord-015021-pol2qm74 5282 12 prevented prevent VBN cord-015021-pol2qm74 5282 13 , , , cord-015021-pol2qm74 5282 14 either either CC cord-015021-pol2qm74 5282 15 by by IN cord-015021-pol2qm74 5282 16 chelating chelate VBG cord-015021-pol2qm74 5282 17 Ca Ca NNP cord-015021-pol2qm74 5282 18 2 2 CD cord-015021-pol2qm74 5283 1 + + CC cord-015021-pol2qm74 5283 2 with with IN cord-015021-pol2qm74 5283 3 EGTA EGTA NNP cord-015021-pol2qm74 5283 4 or or CC cord-015021-pol2qm74 5283 5 by by IN cord-015021-pol2qm74 5283 6 inhibiting inhibit VBG cord-015021-pol2qm74 5283 7 Ca2 ca2 CD cord-015021-pol2qm74 5283 8 + + CC cord-015021-pol2qm74 5283 9 re re NN cord-015021-pol2qm74 5283 10 - - NN cord-015021-pol2qm74 5283 11 uptake uptake JJ cord-015021-pol2qm74 5283 12 with with IN cord-015021-pol2qm74 5283 13 ruthenium ruthenium JJ cord-015021-pol2qm74 5283 14 red red JJ cord-015021-pol2qm74 5283 15 . . . cord-015021-pol2qm74 5284 1 These these DT cord-015021-pol2qm74 5284 2 findings finding NNS cord-015021-pol2qm74 5284 3 suggest suggest VBP cord-015021-pol2qm74 5284 4 that that IN cord-015021-pol2qm74 5284 5 the the DT cord-015021-pol2qm74 5284 6 deleterious deleterious JJ cord-015021-pol2qm74 5284 7 effect effect NN cord-015021-pol2qm74 5284 8 of of IN cord-015021-pol2qm74 5284 9 free free JJ cord-015021-pol2qm74 5284 10 radicals radical NNS cord-015021-pol2qm74 5284 11 on on IN cord-015021-pol2qm74 5284 12 mitochondria mitochondrion NNS cord-015021-pol2qm74 5284 13 in in IN cord-015021-pol2qm74 5284 14 the the DT cord-015021-pol2qm74 5284 15 present present JJ cord-015021-pol2qm74 5284 16 experimental experimental JJ cord-015021-pol2qm74 5284 17 system system NN cord-015021-pol2qm74 5284 18 was be VBD cord-015021-pol2qm74 5284 19 triggered trigger VBN cord-015021-pol2qm74 5284 20 by by IN cord-015021-pol2qm74 5284 21 the the DT cord-015021-pol2qm74 5284 22 CyA cya NN cord-015021-pol2qm74 5284 23 - - HYPH cord-015021-pol2qm74 5284 24 sensitive sensitive JJ cord-015021-pol2qm74 5284 25 and and CC cord-015021-pol2qm74 5284 26 Ca2÷-dependent ca2÷-dependent JJ cord-015021-pol2qm74 5284 27 membrane membrane NN cord-015021-pol2qm74 5284 28 transition transition NN cord-015021-pol2qm74 5284 29 , , , cord-015021-pol2qm74 5284 30 and and CC cord-015021-pol2qm74 5284 31 not not RB cord-015021-pol2qm74 5284 32 by by IN cord-015021-pol2qm74 5284 33 direct direct JJ cord-015021-pol2qm74 5284 34 impairment impairment NN cord-015021-pol2qm74 5284 35 of of IN cord-015021-pol2qm74 5284 36 the the DT cord-015021-pol2qm74 5284 37 mitochondrial mitochondrial JJ cord-015021-pol2qm74 5284 38 inner inner JJ cord-015021-pol2qm74 5284 39 membrane membrane NN cord-015021-pol2qm74 5284 40 enzymes enzyme NNS cord-015021-pol2qm74 5284 41 . . . cord-015021-pol2qm74 5285 1 Correspondence correspondence NN cord-015021-pol2qm74 5285 2 should should MD cord-015021-pol2qm74 5285 3 be be VB cord-015021-pol2qm74 5285 4 addressed address VBN cord-015021-pol2qm74 5285 5 to to IN cord-015021-pol2qm74 5285 6 : : : cord-015021-pol2qm74 5285 7 Naoshi Naoshi NNP cord-015021-pol2qm74 5285 8 Takeyama Takeyama NNP cord-015021-pol2qm74 5286 1 The the DT cord-015021-pol2qm74 5286 2 aim aim NN cord-015021-pol2qm74 5286 3 of of IN cord-015021-pol2qm74 5286 4 this this DT cord-015021-pol2qm74 5286 5 study study NN cord-015021-pol2qm74 5286 6 was be VBD cord-015021-pol2qm74 5286 7 to to TO cord-015021-pol2qm74 5286 8 clarify clarify VB cord-015021-pol2qm74 5286 9 the the DT cord-015021-pol2qm74 5286 10 critical critical JJ cord-015021-pol2qm74 5286 11 role role NN cord-015021-pol2qm74 5286 12 of of IN cord-015021-pol2qm74 5286 13 reduced reduce VBN cord-015021-pol2qm74 5286 14 glutathione glutathione NN cord-015021-pol2qm74 5286 15 ( ( -LRB- cord-015021-pol2qm74 5286 16 GSH GSH NNP cord-015021-pol2qm74 5286 17 ) ) -RRB- cord-015021-pol2qm74 5286 18 on on IN cord-015021-pol2qm74 5286 19 the the DT cord-015021-pol2qm74 5286 20 progression progression NN cord-015021-pol2qm74 5286 21 of of IN cord-015021-pol2qm74 5286 22 lipopolysaccharide lipopolysaccharide NN cord-015021-pol2qm74 5286 23 ( ( -LRB- cord-015021-pol2qm74 5286 24 LPS)induced lps)induce VBN cord-015021-pol2qm74 5286 25 liver liver NN cord-015021-pol2qm74 5286 26 damage damage NN cord-015021-pol2qm74 5286 27 of of IN cord-015021-pol2qm74 5286 28 mouse mouse NN cord-015021-pol2qm74 5286 29 . . . cord-015021-pol2qm74 5287 1 The the DT cord-015021-pol2qm74 5287 2 conditions condition NNS cord-015021-pol2qm74 5287 3 of of IN cord-015021-pol2qm74 5287 4 GSH gsh NN cord-015021-pol2qm74 5287 5 - - HYPH cord-015021-pol2qm74 5287 6 depletion depletion NN cord-015021-pol2qm74 5287 7 and and CC cord-015021-pol2qm74 5287 8 -richness -richnes NNS cord-015021-pol2qm74 5287 9 were be VBD cord-015021-pol2qm74 5287 10 produced produce VBN cord-015021-pol2qm74 5287 11 by by IN cord-015021-pol2qm74 5287 12 intraperitoneal intraperitoneal JJ cord-015021-pol2qm74 5287 13 administration administration NN cord-015021-pol2qm74 5287 14 of of IN cord-015021-pol2qm74 5287 15 buthionine buthionine NNP cord-015021-pol2qm74 5287 16 sulfoximine sulfoximine NNP cord-015021-pol2qm74 5287 17 ( ( -LRB- cord-015021-pol2qm74 5287 18 BSO BSO NNP cord-015021-pol2qm74 5287 19 ) ) -RRB- cord-015021-pol2qm74 5287 20 , , , cord-015021-pol2qm74 5287 21 a a DT cord-015021-pol2qm74 5287 22 specific specific JJ cord-015021-pol2qm74 5287 23 inhibitor inhibitor NN cord-015021-pol2qm74 5287 24 of of IN cord-015021-pol2qm74 5287 25 GSH GSH NNP cord-015021-pol2qm74 5287 26 synthetase synthetase NN cord-015021-pol2qm74 5287 27 , , , cord-015021-pol2qm74 5287 28 and and CC cord-015021-pol2qm74 5287 29 of of IN cord-015021-pol2qm74 5287 30 GSH GSH NNP cord-015021-pol2qm74 5287 31 - - HYPH cord-015021-pol2qm74 5287 32 monoethyl monoethyl NNP cord-015021-pol2qm74 5287 33 ester ester NN cord-015021-pol2qm74 5287 34 ( ( -LRB- cord-015021-pol2qm74 5287 35 GSH GSH NNP cord-015021-pol2qm74 5287 36 - - HYPH cord-015021-pol2qm74 5287 37 ME ME NNP cord-015021-pol2qm74 5287 38 ) ) -RRB- cord-015021-pol2qm74 5287 39 , , , cord-015021-pol2qm74 5287 40 respectively respectively RB cord-015021-pol2qm74 5287 41 . . . cord-015021-pol2qm74 5288 1 GSH GSH NNP cord-015021-pol2qm74 5288 2 - - HYPH cord-015021-pol2qm74 5288 3 ME ME NNP cord-015021-pol2qm74 5288 4 , , , cord-015021-pol2qm74 5288 5 which which WDT cord-015021-pol2qm74 5288 6 was be VBD cord-015021-pol2qm74 5288 7 esterified esterify VBN cord-015021-pol2qm74 5288 8 the the DT cord-015021-pol2qm74 5288 9 caboxyl caboxyl NNP cord-015021-pol2qm74 5288 10 group group NN cord-015021-pol2qm74 5288 11 of of IN cord-015021-pol2qm74 5288 12 the the DT cord-015021-pol2qm74 5288 13 glycine glycine NN cord-015021-pol2qm74 5288 14 residue residue NN cord-015021-pol2qm74 5288 15 , , , cord-015021-pol2qm74 5288 16 is be VBZ cord-015021-pol2qm74 5288 17 readily readily RB cord-015021-pol2qm74 5288 18 transported transport VBN cord-015021-pol2qm74 5288 19 into into IN cord-015021-pol2qm74 5288 20 cells cell NNS cord-015021-pol2qm74 5288 21 and and CC cord-015021-pol2qm74 5288 22 is be VBZ cord-015021-pol2qm74 5288 23 hydrolyzed hydrolyze VBN cord-015021-pol2qm74 5288 24 intracellularly intracellularly RB cord-015021-pol2qm74 5288 25 ; ; : cord-015021-pol2qm74 5288 26 this this DT cord-015021-pol2qm74 5288 27 leads lead VBZ cord-015021-pol2qm74 5288 28 to to TO cord-015021-pol2qm74 5288 29 greatly greatly RB cord-015021-pol2qm74 5288 30 increased increase VBN cord-015021-pol2qm74 5288 31 the the DT cord-015021-pol2qm74 5288 32 cytosolic cytosolic JJ cord-015021-pol2qm74 5288 33 and and CC cord-015021-pol2qm74 5288 34 mitochondrial mitochondrial JJ cord-015021-pol2qm74 5288 35 levels level NNS cord-015021-pol2qm74 5288 36 of of IN cord-015021-pol2qm74 5288 37 GSH GSH NNP cord-015021-pol2qm74 5288 38 . . . cord-015021-pol2qm74 5289 1 BSO BSO NNP cord-015021-pol2qm74 5289 2 and and CC cord-015021-pol2qm74 5289 3 GSH GSH NNP cord-015021-pol2qm74 5289 4 - - HYPH cord-015021-pol2qm74 5289 5 ME ME NNP cord-015021-pol2qm74 5289 6 were be VBD cord-015021-pol2qm74 5289 7 administered administer VBN cord-015021-pol2qm74 5289 8 intraperitoneally intraperitoneally RB cord-015021-pol2qm74 5289 9 3 3 CD cord-015021-pol2qm74 5289 10 mmol mmol JJ cord-015021-pol2qm74 5289 11 / / SYM cord-015021-pol2qm74 5289 12 kg kg NNS cord-015021-pol2qm74 5289 13 and and CC cord-015021-pol2qm74 5289 14 10 10 CD cord-015021-pol2qm74 5289 15 mmollkg mmollkg NN cord-015021-pol2qm74 5289 16 , , , cord-015021-pol2qm74 5289 17 respectively respectively RB cord-015021-pol2qm74 5289 18 , , , cord-015021-pol2qm74 5289 19 and and CC cord-015021-pol2qm74 5289 20 LPS LPS NNP cord-015021-pol2qm74 5289 21 ( ( -LRB- cord-015021-pol2qm74 5289 22 2 2 CD cord-015021-pol2qm74 5289 23 mg mg NNP cord-015021-pol2qm74 5289 24 / / SYM cord-015021-pol2qm74 5289 25 kg kg NNP cord-015021-pol2qm74 5289 26 ) ) -RRB- cord-015021-pol2qm74 5289 27 given give VBN cord-015021-pol2qm74 5289 28 1 1 CD cord-015021-pol2qm74 5289 29 h h NN cord-015021-pol2qm74 5289 30 later later RB cord-015021-pol2qm74 5289 31 . . . cord-015021-pol2qm74 5290 1 Hepatocytes hepatocyte NNS cord-015021-pol2qm74 5290 2 were be VBD cord-015021-pol2qm74 5290 3 isolated isolate VBN cord-015021-pol2qm74 5290 4 by by IN cord-015021-pol2qm74 5290 5 in in IN cord-015021-pol2qm74 5290 6 situ situ JJ cord-015021-pol2qm74 5290 7 perfusion perfusion NN cord-015021-pol2qm74 5290 8 of of IN cord-015021-pol2qm74 5290 9 the the DT cord-015021-pol2qm74 5290 10 liver liver NN cord-015021-pol2qm74 5290 11 with with IN cord-015021-pol2qm74 5290 12 collagenase collagenase NNP cord-015021-pol2qm74 5290 13 6 6 CD cord-015021-pol2qm74 5290 14 h h NNP cord-015021-pol2qm74 5290 15 after after IN cord-015021-pol2qm74 5290 16 LPS LPS NNP cord-015021-pol2qm74 5290 17 injection injection NN cord-015021-pol2qm74 5290 18 . . . cord-015021-pol2qm74 5291 1 The the DT cord-015021-pol2qm74 5291 2 degree degree NN cord-015021-pol2qm74 5291 3 of of IN cord-015021-pol2qm74 5291 4 hydrogen hydrogen NN cord-015021-pol2qm74 5291 5 peroxide peroxide NN cord-015021-pol2qm74 5291 6 ( ( -LRB- cord-015021-pol2qm74 5291 7 H202 H202 NNP cord-015021-pol2qm74 5291 8 ) ) -RRB- cord-015021-pol2qm74 5291 9 synthesis synthesis NN cord-015021-pol2qm74 5291 10 and and CC cord-015021-pol2qm74 5291 11 mitochondrial mitochondrial JJ cord-015021-pol2qm74 5291 12 membrane membrane NN cord-015021-pol2qm74 5291 13 potential potential NN cord-015021-pol2qm74 5291 14 were be VBD cord-015021-pol2qm74 5291 15 measured measure VBN cord-015021-pol2qm74 5291 16 by by IN cord-015021-pol2qm74 5291 17 flow flow NN cord-015021-pol2qm74 5291 18 cytometry cytometry NN cord-015021-pol2qm74 5291 19 using use VBG cord-015021-pol2qm74 5291 20 fluorescence fluorescence NN cord-015021-pol2qm74 5291 21 probe probe NN cord-015021-pol2qm74 5291 22 dichrolofluorescein dichrolofluorescein NNP cord-015021-pol2qm74 5291 23 diacetate diacetate NNP cord-015021-pol2qm74 5291 24 and and CC cord-015021-pol2qm74 5291 25 tetrametyl tetrametyl NNP cord-015021-pol2qm74 5291 26 rhodamine rhodamine NNP cord-015021-pol2qm74 5291 27 ethyl ethyl NNP cord-015021-pol2qm74 5291 28 ester ester NN cord-015021-pol2qm74 5291 29 , , , cord-015021-pol2qm74 5291 30 respectively respectively RB cord-015021-pol2qm74 5291 31 . . . cord-015021-pol2qm74 5292 1 The the DT cord-015021-pol2qm74 5292 2 degree degree NN cord-015021-pol2qm74 5292 3 of of IN cord-015021-pol2qm74 5292 4 mitochondria mitochondrion NNS cord-015021-pol2qm74 5292 5 membrane membrane NN cord-015021-pol2qm74 5292 6 permeability permeability NN cord-015021-pol2qm74 5292 7 transition transition NN cord-015021-pol2qm74 5292 8 ( ( -LRB- cord-015021-pol2qm74 5292 9 MMP MMP NNP cord-015021-pol2qm74 5292 10 ) ) -RRB- cord-015021-pol2qm74 5292 11 was be VBD cord-015021-pol2qm74 5292 12 assessed assess VBN cord-015021-pol2qm74 5292 13 by by IN cord-015021-pol2qm74 5292 14 [ [ -LRB- cord-015021-pol2qm74 5292 15 014]sucrose 014]sucrose CD cord-015021-pol2qm74 5292 16 entrapment entrapment NN cord-015021-pol2qm74 5292 17 . . . cord-015021-pol2qm74 5293 1 We -PRON- PRP cord-015021-pol2qm74 5293 2 found find VBD cord-015021-pol2qm74 5293 3 that that IN cord-015021-pol2qm74 5293 4 LPS LPS NNP cord-015021-pol2qm74 5293 5 treatment treatment NN cord-015021-pol2qm74 5293 6 results result NNS cord-015021-pol2qm74 5293 7 in in IN cord-015021-pol2qm74 5293 8 a a DT cord-015021-pol2qm74 5293 9 decrease decrease NN cord-015021-pol2qm74 5293 10 in in IN cord-015021-pol2qm74 5293 11 hepatic hepatic JJ cord-015021-pol2qm74 5293 12 GSH GSH NNP cord-015021-pol2qm74 5293 13 level level NN cord-015021-pol2qm74 5293 14 and and CC cord-015021-pol2qm74 5293 15 mitochondrial mitochondrial JJ cord-015021-pol2qm74 5293 16 membrane membrane NN cord-015021-pol2qm74 5293 17 potential potential NN cord-015021-pol2qm74 5293 18 , , , cord-015021-pol2qm74 5293 19 and and CC cord-015021-pol2qm74 5293 20 an an DT cord-015021-pol2qm74 5293 21 increase increase NN cord-015021-pol2qm74 5293 22 in in IN cord-015021-pol2qm74 5293 23 H202 h202 NN cord-015021-pol2qm74 5293 24 synthesis synthesis NN cord-015021-pol2qm74 5293 25 and and CC cord-015021-pol2qm74 5293 26 MMP MMP NNP cord-015021-pol2qm74 5293 27 . . . cord-015021-pol2qm74 5294 1 LPS LPS NNP cord-015021-pol2qm74 5294 2 administration administration NN cord-015021-pol2qm74 5294 3 to to IN cord-015021-pol2qm74 5294 4 BSQ bsq NN cord-015021-pol2qm74 5294 5 - - HYPH cord-015021-pol2qm74 5294 6 pretreated pretreate VBN cord-015021-pol2qm74 5294 7 mouse mouse NN cord-015021-pol2qm74 5294 8 worsened worsen VBD cord-015021-pol2qm74 5294 9 at at IN cord-015021-pol2qm74 5294 10 [ [ -LRB- cord-015021-pol2qm74 5294 11 these these DT cord-015021-pol2qm74 5294 12 parameters parameter NNS cord-015021-pol2qm74 5294 13 . . . cord-015021-pol2qm74 5295 1 In in IN cord-015021-pol2qm74 5295 2 contrast contrast NN cord-015021-pol2qm74 5295 3 , , , cord-015021-pol2qm74 5295 4 GSH GSH NNP cord-015021-pol2qm74 5295 5 - - HYPH cord-015021-pol2qm74 5295 6 ME ME NNP cord-015021-pol2qm74 5295 7 pretreatment pretreatment NN cord-015021-pol2qm74 5295 8 ameliorates ameliorate VBZ cord-015021-pol2qm74 5295 9 . . . cord-015021-pol2qm74 5296 1 All all RB cord-015021-pol2qm74 5296 2 together together RB cord-015021-pol2qm74 5296 3 , , , cord-015021-pol2qm74 5296 4 GSH GSH NNP cord-015021-pol2qm74 5296 5 may may MD cord-015021-pol2qm74 5296 6 acts act VBZ cord-015021-pol2qm74 5296 7 an an DT cord-015021-pol2qm74 5296 8 important important JJ cord-015021-pol2qm74 5296 9 role role NN cord-015021-pol2qm74 5296 10 in in IN cord-015021-pol2qm74 5296 11 cellular cellular JJ cord-015021-pol2qm74 5296 12 defence defence NN cord-015021-pol2qm74 5296 13 against against IN cord-015021-pol2qm74 5296 14 LPS LPS NNP cord-015021-pol2qm74 5296 15 - - HYPH cord-015021-pol2qm74 5296 16 mediated mediate VBN cord-015021-pol2qm74 5296 17 liver liver NN cord-015021-pol2qm74 5296 18 damage damage NN cord-015021-pol2qm74 5296 19 , , , cord-015021-pol2qm74 5296 20 and and CC cord-015021-pol2qm74 5296 21 MMP MMP NNP cord-015021-pol2qm74 5296 22 may may MD cord-015021-pol2qm74 5296 23 result result VB cord-015021-pol2qm74 5296 24 in in IN cord-015021-pol2qm74 5296 25 the the DT cord-015021-pol2qm74 5296 26 decrease decrease NN cord-015021-pol2qm74 5296 27 in in IN cord-015021-pol2qm74 5296 28 mitochondrial mitochondrial JJ cord-015021-pol2qm74 5296 29 membrane membrane NN cord-015021-pol2qm74 5296 30 potential potential NN cord-015021-pol2qm74 5296 31 . . . cord-015021-pol2qm74 5297 1 It -PRON- PRP cord-015021-pol2qm74 5297 2 has have VBZ cord-015021-pol2qm74 5297 3 been be VBN cord-015021-pol2qm74 5297 4 shown show VBN cord-015021-pol2qm74 5297 5 , , , cord-015021-pol2qm74 5297 6 up up IN cord-015021-pol2qm74 5297 7 to to IN cord-015021-pol2qm74 5297 8 now now RB cord-015021-pol2qm74 5297 9 , , , cord-015021-pol2qm74 5297 10 that that IN cord-015021-pol2qm74 5297 11 disturbances disturbance NNS cord-015021-pol2qm74 5297 12 of of IN cord-015021-pol2qm74 5297 13 enzymatic enzymatic JJ cord-015021-pol2qm74 5297 14 processes process NNS cord-015021-pol2qm74 5297 15 in in IN cord-015021-pol2qm74 5297 16 the the DT cord-015021-pol2qm74 5297 17 cell cell NN cord-015021-pol2qm74 5297 18 organella organella NN cord-015021-pol2qm74 5297 19 are be VBP cord-015021-pol2qm74 5297 20 the the DT cord-015021-pol2qm74 5297 21 basic basic JJ cord-015021-pol2qm74 5297 22 factor factor NN cord-015021-pol2qm74 5297 23 of of IN cord-015021-pol2qm74 5297 24 the the DT cord-015021-pol2qm74 5297 25 changes change NNS cord-015021-pol2qm74 5297 26 taking take VBG cord-015021-pol2qm74 5297 27 place place NN cord-015021-pol2qm74 5297 28 during during IN cord-015021-pol2qm74 5297 29 endotoxin endotoxin NN cord-015021-pol2qm74 5297 30 shock shock NN cord-015021-pol2qm74 5298 1 It -PRON- PRP cord-015021-pol2qm74 5298 2 has have VBZ cord-015021-pol2qm74 5298 3 been be VBN cord-015021-pol2qm74 5298 4 observed observe VBN cord-015021-pol2qm74 5298 5 that that IN cord-015021-pol2qm74 5298 6 lysosomes lysosome NNS cord-015021-pol2qm74 5298 7 are be VBP cord-015021-pol2qm74 5298 8 biochemically biochemically RB cord-015021-pol2qm74 5298 9 changed change VBN cord-015021-pol2qm74 5298 10 as as IN cord-015021-pol2qm74 5298 11 result result NN cord-015021-pol2qm74 5298 12 of of IN cord-015021-pol2qm74 5298 13 the the DT cord-015021-pol2qm74 5298 14 effect effect NN cord-015021-pol2qm74 5298 15 of of IN cord-015021-pol2qm74 5298 16 lipopotysacharides lipopotysacharide NNS cord-015021-pol2qm74 5298 17 of of IN cord-015021-pol2qm74 5298 18 gram gram NN cord-015021-pol2qm74 5298 19 negative negative JJ cord-015021-pol2qm74 5298 20 endotoxic endotoxic JJ cord-015021-pol2qm74 5298 21 bacteria bacteria NNS cord-015021-pol2qm74 5298 22 . . . cord-015021-pol2qm74 5299 1 The the DT cord-015021-pol2qm74 5299 2 purpose purpose NN cord-015021-pol2qm74 5299 3 of of IN cord-015021-pol2qm74 5299 4 the the DT cord-015021-pol2qm74 5299 5 experiment experiment NN cord-015021-pol2qm74 5299 6 was be VBD cord-015021-pol2qm74 5299 7 : : : cord-015021-pol2qm74 5299 8 1.evaluation 1.evaluation CD cord-015021-pol2qm74 5299 9 nfthe nfthe NNP cord-015021-pol2qm74 5299 10 course course NN cord-015021-pol2qm74 5299 11 of of IN cord-015021-pol2qm74 5299 12 the the DT cord-015021-pol2qm74 5299 13 EES EES NNP cord-015021-pol2qm74 5299 14 due due IN cord-015021-pol2qm74 5299 15 to to IN cord-015021-pol2qm74 5299 16 the the DT cord-015021-pol2qm74 5299 17 biochemic biochemic JJ cord-015021-pol2qm74 5299 18 changes change VBZ cord-015021-pol2qm74 5299 19 2.determination 2.determination CD cord-015021-pol2qm74 5299 20 of of IN cord-015021-pol2qm74 5299 21 the the DT cord-015021-pol2qm74 5299 22 influence influence NN cord-015021-pol2qm74 5299 23 of of IN cord-015021-pol2qm74 5299 24 the the DT cord-015021-pol2qm74 5299 25 EES EES NNP cord-015021-pol2qm74 5299 26 on on IN cord-015021-pol2qm74 5299 27 the the DT cord-015021-pol2qm74 5299 28 activity activity NN cord-015021-pol2qm74 5299 29 of of IN cord-015021-pol2qm74 5299 30 lysosomal lysosomal JJ cord-015021-pol2qm74 5299 31 enzymes enzyme NNS cord-015021-pol2qm74 5299 32 in in IN cord-015021-pol2qm74 5299 33 liver liver NN cord-015021-pol2qm74 5299 34 cell cell NN cord-015021-pol2qm74 5299 35 3.deterrmnatian 3.deterrmnatian CD cord-015021-pol2qm74 5299 36 of of IN cord-015021-pol2qm74 5299 37 the the DT cord-015021-pol2qm74 5299 38 influence influence NN cord-015021-pol2qm74 5299 39 of of IN cord-015021-pol2qm74 5299 40 H h NN cord-015021-pol2qm74 5299 41 and and CC cord-015021-pol2qm74 5299 42 D d NN cord-015021-pol2qm74 5299 43 on on IN cord-015021-pol2qm74 5299 44 the the DT cord-015021-pol2qm74 5299 45 activity activity NN cord-015021-pol2qm74 5299 46 of of IN cord-015021-pol2qm74 5299 47 some some DT cord-015021-pol2qm74 5299 48 lysosomal lysosomal JJ cord-015021-pol2qm74 5299 49 enzymes enzyme NNS cord-015021-pol2qm74 5299 50 in in IN cord-015021-pol2qm74 5299 51 liver liver NN cord-015021-pol2qm74 5299 52 cell cell NN cord-015021-pol2qm74 5299 53 during during IN cord-015021-pol2qm74 5299 54 EES EES NNP cord-015021-pol2qm74 5299 55 Material Material NNP cord-015021-pol2qm74 5299 56 and and CC cord-015021-pol2qm74 5299 57 method method NN cord-015021-pol2qm74 5299 58 : : : cord-015021-pol2qm74 5300 1 Examinations examination NNS cord-015021-pol2qm74 5300 2 ware ware NNP cord-015021-pol2qm74 5300 3 carried carry VBD cord-015021-pol2qm74 5300 4 out out RP cord-015021-pol2qm74 5300 5 on on IN cord-015021-pol2qm74 5300 6 30 30 CD cord-015021-pol2qm74 5300 7 dogs dog NNS cord-015021-pol2qm74 5300 8 . . . cord-015021-pol2qm74 5301 1 The the DT cord-015021-pol2qm74 5301 2 shock shock NN cord-015021-pol2qm74 5301 3 was be VBD cord-015021-pol2qm74 5301 4 evoked evoke VBN cord-015021-pol2qm74 5301 5 by by IN cord-015021-pol2qm74 5301 6 i.v i.v NNP cord-015021-pol2qm74 5301 7 . . NNP cord-015021-pol2qm74 5301 8 administration administration NN cord-015021-pol2qm74 5301 9 of of IN cord-015021-pol2qm74 5301 10 endotoxin endotoxin NNP cord-015021-pol2qm74 5301 11 E.coli E.coli NNP cord-015021-pol2qm74 5301 12 . . . cord-015021-pol2qm74 5302 1 The the DT cord-015021-pol2qm74 5302 2 dogs dog NNS cord-015021-pol2qm74 5302 3 were be VBD cord-015021-pol2qm74 5302 4 divided divide VBN cord-015021-pol2qm74 5302 5 into into IN cord-015021-pol2qm74 5302 6 5 5 CD cord-015021-pol2qm74 5302 7 groups group NNS cord-015021-pol2qm74 5302 8 : : : cord-015021-pol2qm74 5303 1 Icontrols Icontrols NNP cord-015021-pol2qm74 5303 2 , , , cord-015021-pol2qm74 5303 3 I -PRON- PRP cord-015021-pol2qm74 5303 4 [ [ -LRB- cord-015021-pol2qm74 5303 5 -dogs -dog NNS cord-015021-pol2qm74 5303 6 with with IN cord-015021-pol2qm74 5303 7 untreated untreated JJ cord-015021-pol2qm74 5303 8 shock shock NN cord-015021-pol2qm74 5303 9 , , , cord-015021-pol2qm74 5303 10 III III NNP cord-015021-pol2qm74 5303 11 - - HYPH cord-015021-pol2qm74 5303 12 dogs dog NNS cord-015021-pol2qm74 5303 13 in in IN cord-015021-pol2qm74 5303 14 shock shock NN cord-015021-pol2qm74 5303 15 treated treat VBN cord-015021-pol2qm74 5303 16 with with IN cord-015021-pol2qm74 5303 17 H H NNP cord-015021-pol2qm74 5303 18 , , , cord-015021-pol2qm74 5303 19 IVdogs IVdogs NNP cord-015021-pol2qm74 5303 20 in in IN cord-015021-pol2qm74 5303 21 shock shock NN cord-015021-pol2qm74 5303 22 treated treat VBN cord-015021-pol2qm74 5303 23 with with IN cord-015021-pol2qm74 5303 24 D D NNP cord-015021-pol2qm74 5303 25 , , , cord-015021-pol2qm74 5303 26 V v NN cord-015021-pol2qm74 5303 27 -dogs -dogs NN cord-015021-pol2qm74 5304 1 in in IN cord-015021-pol2qm74 5304 2 shock shock NN cord-015021-pol2qm74 5304 3 treated treat VBN cord-015021-pol2qm74 5304 4 with with IN cord-015021-pol2qm74 5304 5 H H NNP cord-015021-pol2qm74 5304 6 and and CC cord-015021-pol2qm74 5304 7 D. D. NNP cord-015021-pol2qm74 5305 1 The the DT cord-015021-pol2qm74 5305 2 following following JJ cord-015021-pol2qm74 5305 3 parameters parameter NNS cord-015021-pol2qm74 5305 4 were be VBD cord-015021-pol2qm74 5305 5 determined determine VBN cord-015021-pol2qm74 5305 6 : : : cord-015021-pol2qm74 5305 7 1.Activity 1.activity CD cord-015021-pol2qm74 5305 8 of of IN cord-015021-pol2qm74 5305 9 acid acid NN cord-015021-pol2qm74 5305 10 phosphatase phosphatase NN cord-015021-pol2qm74 5305 11 in in IN cord-015021-pol2qm74 5305 12 the the DT cord-015021-pol2qm74 5305 13 venous venous JJ cord-015021-pol2qm74 5305 14 blood blood NN cord-015021-pol2qm74 5305 15 serum serum NN cord-015021-pol2qm74 5305 16 . . . cord-015021-pol2qm74 5306 1 2 2 LS cord-015021-pol2qm74 5306 2 - - SYM cord-015021-pol2qm74 5306 3 6.Total 6.total CD cord-015021-pol2qm74 5306 4 and and CC cord-015021-pol2qm74 5306 5 free free JJ cord-015021-pol2qm74 5306 6 activity activity NN cord-015021-pol2qm74 5306 7 of of IN cord-015021-pol2qm74 5306 8 acid acid NN cord-015021-pol2qm74 5306 9 phosphatase phosphatase NN cord-015021-pol2qm74 5306 10 and and CC cord-015021-pol2qm74 5306 11 catepsins catepsin NNS cord-015021-pol2qm74 5306 12 in in IN cord-015021-pol2qm74 5306 13 the the DT cord-015021-pol2qm74 5306 14 full full JJ cord-015021-pol2qm74 5306 15 liver liver NN cord-015021-pol2qm74 5306 16 cell cell NN cord-015021-pol2qm74 5306 17 homogenate homogenate NNP cord-015021-pol2qm74 5306 18 , , , cord-015021-pol2qm74 5306 19 in in IN cord-015021-pol2qm74 5306 20 mitochondrial mitochondrial NN cord-015021-pol2qm74 5306 21 - - HYPH cord-015021-pol2qm74 5306 22 and and CC cord-015021-pol2qm74 5306 23 - - HYPH cord-015021-pol2qm74 5306 24 lysosomal lysosomal NN cord-015021-pol2qm74 5306 25 fraction fraction NN cord-015021-pol2qm74 5306 26 , , , cord-015021-pol2qm74 5306 27 and and CC cord-015021-pol2qm74 5306 28 in in IN cord-015021-pol2qm74 5306 29 the the DT cord-015021-pol2qm74 5306 30 superuatunt superuatunt NN cord-015021-pol2qm74 5306 31 ( ( -LRB- cord-015021-pol2qm74 5306 32 all all RB cord-015021-pol2qm74 5306 33 after after IN cord-015021-pol2qm74 5306 34 4 4 CD cord-015021-pol2qm74 5306 35 hours hour NNS cord-015021-pol2qm74 5306 36 of of IN cord-015021-pol2qm74 5306 37 the the DT cord-015021-pol2qm74 5306 38 experiment experiment NN cord-015021-pol2qm74 5306 39 ) ) -RRB- cord-015021-pol2qm74 5306 40 . . . cord-015021-pol2qm74 5307 1 Conclusions conclusion NNS cord-015021-pol2qm74 5307 2 1 1 CD cord-015021-pol2qm74 5307 3 . . . cord-015021-pol2qm74 5308 1 Essential essential JJ cord-015021-pol2qm74 5308 2 increase increase NN cord-015021-pol2qm74 5308 3 of of IN cord-015021-pol2qm74 5308 4 activity activity NN cord-015021-pol2qm74 5308 5 of of IN cord-015021-pol2qm74 5308 6 lysosomal lysosomal JJ cord-015021-pol2qm74 5308 7 enzymes enzyme NNS cord-015021-pol2qm74 5308 8 was be VBD cord-015021-pol2qm74 5308 9 observed observe VBN cord-015021-pol2qm74 5308 10 in in IN cord-015021-pol2qm74 5308 11 the the DT cord-015021-pol2qm74 5308 12 EES EES NNP cord-015021-pol2qm74 5308 13 . . . cord-015021-pol2qm74 5309 1 2 2 LS cord-015021-pol2qm74 5309 2 . . . cord-015021-pol2qm74 5310 1 Increased increase VBN cord-015021-pol2qm74 5310 2 activity activity NN cord-015021-pol2qm74 5310 3 of of IN cord-015021-pol2qm74 5310 4 lysosomal lysosomal JJ cord-015021-pol2qm74 5310 5 hydrolases hydrolase NNS cord-015021-pol2qm74 5310 6 in in IN cord-015021-pol2qm74 5310 7 the the DT cord-015021-pol2qm74 5310 8 liver liver NN cord-015021-pol2qm74 5310 9 cell cell NN cord-015021-pol2qm74 5310 10 homogenate homogenate NNP cord-015021-pol2qm74 5310 11 corresponds correspond VBZ cord-015021-pol2qm74 5310 12 , , , cord-015021-pol2qm74 5310 13 as as IN cord-015021-pol2qm74 5310 14 a a DT cord-015021-pol2qm74 5310 15 result result NN cord-015021-pol2qm74 5310 16 of of IN cord-015021-pol2qm74 5310 17 the the DT cord-015021-pol2qm74 5310 18 endotoxin endotoxin NN cord-015021-pol2qm74 5310 19 effect effect NN cord-015021-pol2qm74 5310 20 , , , cord-015021-pol2qm74 5310 21 with with IN cord-015021-pol2qm74 5310 22 increased increase VBN cord-015021-pol2qm74 5310 23 enzymatic enzymatic JJ cord-015021-pol2qm74 5310 24 activity activity NN cord-015021-pol2qm74 5310 25 in in IN cord-015021-pol2qm74 5310 26 the the DT cord-015021-pol2qm74 5310 27 peripherial peripherial JJ cord-015021-pol2qm74 5310 28 blood blood NN cord-015021-pol2qm74 5310 29 . . . cord-015021-pol2qm74 5311 1 Extensive extensive JJ cord-015021-pol2qm74 5311 2 investigations investigation NNS cord-015021-pol2qm74 5311 3 from from IN cord-015021-pol2qm74 5311 4 our -PRON- PRP$ cord-015021-pol2qm74 5311 5 laboratory laboratory NN cord-015021-pol2qm74 5311 6 of of IN cord-015021-pol2qm74 5311 7 the the DT cord-015021-pol2qm74 5311 8 pathophysiology pathophysiology NN cord-015021-pol2qm74 5311 9 of of IN cord-015021-pol2qm74 5311 10 hepatic hepatic JJ cord-015021-pol2qm74 5311 11 no no DT cord-015021-pol2qm74 5311 12 - - HYPH cord-015021-pol2qm74 5311 13 flow flow NN cord-015021-pol2qm74 5311 14 ischemia ischemia NN cord-015021-pol2qm74 5311 15 ( ( -LRB- cord-015021-pol2qm74 5311 16 45 45 CD cord-015021-pol2qm74 5311 17 min min NN cord-015021-pol2qm74 5311 18 ) ) -RRB- cord-015021-pol2qm74 5312 1 -reperfusion -reperfusion : cord-015021-pol2qm74 5312 2 injury injury NN cord-015021-pol2qm74 5312 3 demonstrated demonstrate VBD cord-015021-pol2qm74 5312 4 substantial substantial JJ cord-015021-pol2qm74 5312 5 Kupffer Kupffer NNP cord-015021-pol2qm74 5312 6 cell cell NN cord-015021-pol2qm74 5312 7 activation activation NN cord-015021-pol2qm74 5312 8 with with IN cord-015021-pol2qm74 5312 9 reactive reactive JJ cord-015021-pol2qm74 5312 10 oxygen oxygen NN cord-015021-pol2qm74 5312 11 formation formation NN cord-015021-pol2qm74 5312 12 during during IN cord-015021-pol2qm74 5312 13 the the DT cord-015021-pol2qm74 5312 14 first first JJ cord-015021-pol2qm74 5312 15 few few JJ cord-015021-pol2qm74 5312 16 hours hour NNS cord-015021-pol2qm74 5312 17 of of IN cord-015021-pol2qm74 5312 18 reperfusion reperfusion NN cord-015021-pol2qm74 5312 19 as as IN cord-015021-pol2qm74 5312 20 indicated indicate VBN cord-015021-pol2qm74 5312 21 by by IN cord-015021-pol2qm74 5312 22 increases increase NNS cord-015021-pol2qm74 5312 23 in in IN cord-015021-pol2qm74 5312 24 plasma plasma NN cord-015021-pol2qm74 5312 25 glutathione glutathione NN cord-015021-pol2qm74 5312 26 disulfide disulfide NN cord-015021-pol2qm74 5313 1 ( ( -LRB- cord-015021-pol2qm74 5313 2 GSSG GSSG NNP cord-015021-pol2qm74 5313 3 ) ) -RRB- cord-015021-pol2qm74 5313 4 levels level NNS cord-015021-pol2qm74 5313 5 in in IN cord-015021-pol2qm74 5313 6 vivo vivo NN cord-015021-pol2qm74 5313 7 ( ( -LRB- cord-015021-pol2qm74 5313 8 Am Am NNP cord-015021-pol2qm74 5313 9 . . . cord-015021-pol2qm74 5314 1 J. J. NNP cord-015021-pol2qm74 5314 2 Physiol Physiol NNP cord-015021-pol2qm74 5314 3 . . . cord-015021-pol2qm74 5314 4 260 260 CD cord-015021-pol2qm74 5314 5 : : : cord-015021-pol2qm74 5314 6 G355 g355 CD cord-015021-pol2qm74 5314 7 , , , cord-015021-pol2qm74 5314 8 1991 1991 CD cord-015021-pol2qm74 5314 9 ) ) -RRB- cord-015021-pol2qm74 5314 10 and and CC cord-015021-pol2qm74 5314 11 enhanced enhanced JJ cord-015021-pol2qm74 5314 12 superoxide superoxide NN cord-015021-pol2qm74 5314 13 formation formation NN cord-015021-pol2qm74 5314 14 by by IN cord-015021-pol2qm74 5314 15 Kupffer Kupffer NNP cord-015021-pol2qm74 5314 16 cells cell NNS cord-015021-pol2qm74 5314 17 ( ( -LRB- cord-015021-pol2qm74 5314 18 KC KC NNP cord-015021-pol2qm74 5314 19 ) ) -RRB- cord-015021-pol2qm74 5314 20 isolated isolate VBN cord-015021-pol2qm74 5314 21 from from IN cord-015021-pol2qm74 5314 22 the the DT cord-015021-pol2qm74 5314 23 postischemic postischemic JJ cord-015021-pol2qm74 5314 24 livers liver NNS cord-015021-pol2qm74 5314 25 ( ( -LRB- cord-015021-pol2qm74 5314 26 Free Free NNP cord-015021-pol2qm74 5314 27 Radic Radic NNP cord-015021-pol2qm74 5314 28 . . . cord-015021-pol2qm74 5315 1 Res Res NNP cord-015021-pol2qm74 5315 2 . . NNP cord-015021-pol2qm74 5315 3 Commun Commun NNP cord-015021-pol2qm74 5315 4 . . . cord-015021-pol2qm74 5316 1 15:277 15:277 CD cord-015021-pol2qm74 5316 2 , , , cord-015021-pol2qm74 5316 3 1991 1991 CD cord-015021-pol2qm74 5316 4 ) ) -RRB- cord-015021-pol2qm74 5316 5 . . . cord-015021-pol2qm74 5317 1 The the DT cord-015021-pol2qm74 5317 2 early early JJ cord-015021-pol2qm74 5317 3 KC KC NNP cord-015021-pol2qm74 5317 4 - - HYPH cord-015021-pol2qm74 5317 5 induced induce VBN cord-015021-pol2qm74 5317 6 injury injury NN cord-015021-pol2qm74 5317 7 initiated initiate VBD cord-015021-pol2qm74 5317 8 the the DT cord-015021-pol2qm74 5317 9 later later RBR cord-015021-pol2qm74 5317 10 , , , cord-015021-pol2qm74 5317 11 primarily primarily RB cord-015021-pol2qm74 5317 12 neutrophilmediated neutrophilmediate VBD cord-015021-pol2qm74 5317 13 reperfusion reperfusion NN cord-015021-pol2qm74 5317 14 injury injury NN cord-015021-pol2qm74 5317 15 ( ( -LRB- cord-015021-pol2qm74 5317 16 FASEB FASEB NNP cord-015021-pol2qm74 5317 17 J. J. NNP cord-015021-pol2qm74 5317 18 4 4 CD cord-015021-pol2qm74 5317 19 : : : cord-015021-pol2qm74 5317 20 3355 3355 CD cord-015021-pol2qm74 5317 21 , , , cord-015021-pol2qm74 5317 22 1990 1990 CD cord-015021-pol2qm74 5317 23 ) ) -RRB- cord-015021-pol2qm74 5317 24 . . . cord-015021-pol2qm74 5318 1 To to TO cord-015021-pol2qm74 5318 2 test test VB cord-015021-pol2qm74 5318 3 whether whether IN cord-015021-pol2qm74 5318 4 or or CC cord-015021-pol2qm74 5318 5 not not RB cord-015021-pol2qm74 5318 6 similar similar JJ cord-015021-pol2qm74 5318 7 mechanisms mechanism NNS cord-015021-pol2qm74 5318 8 are be VBP cord-015021-pol2qm74 5318 9 operative operative JJ cord-015021-pol2qm74 5318 10 during during IN cord-015021-pol2qm74 5318 11 hepatic hepatic JJ cord-015021-pol2qm74 5318 12 ischemia ischemia NN cord-015021-pol2qm74 5318 13 induced induce VBN cord-015021-pol2qm74 5318 14 by by IN cord-015021-pol2qm74 5318 15 hemorrhagic hemorrhagic JJ cord-015021-pol2qm74 5318 16 shock shock NN cord-015021-pol2qm74 5318 17 , , , cord-015021-pol2qm74 5318 18 male male JJ cord-015021-pol2qm74 5318 19 Fischer Fischer NNP cord-015021-pol2qm74 5318 20 rats rat NNS cord-015021-pol2qm74 5318 21 ( ( -LRB- cord-015021-pol2qm74 5318 22 230 230 CD cord-015021-pol2qm74 5318 23 - - SYM cord-015021-pol2qm74 5318 24 250 250 CD cord-015021-pol2qm74 5318 25 g g NN cord-015021-pol2qm74 5318 26 ) ) -RRB- cord-015021-pol2qm74 5318 27 were be VBD cord-015021-pol2qm74 5318 28 subjected subject VBN cord-015021-pol2qm74 5318 29 to to IN cord-015021-pol2qm74 5318 30 60 60 CD cord-015021-pol2qm74 5318 31 rain rain NN cord-015021-pol2qm74 5318 32 of of IN cord-015021-pol2qm74 5318 33 hemorrhage hemorrhage NN cord-015021-pol2qm74 5318 34 ( ( -LRB- cord-015021-pol2qm74 5318 35 mean mean VB cord-015021-pol2qm74 5319 1 arterial arterial JJ cord-015021-pol2qm74 5319 2 pressure pressure NN cord-015021-pol2qm74 5319 3 40 40 CD cord-015021-pol2qm74 5319 4 mm mm CD cord-015021-pol2qm74 5319 5 Hg Hg NNP cord-015021-pol2qm74 5319 6 ) ) -RRB- cord-015021-pol2qm74 5319 7 followed follow VBN cord-015021-pol2qm74 5319 8 by by IN cord-015021-pol2qm74 5319 9 resuscitation resuscitation NN cord-015021-pol2qm74 5319 10 ( ( -LRB- cord-015021-pol2qm74 5319 11 RS rs NN cord-015021-pol2qm74 5319 12 ) ) -RRB- cord-015021-pol2qm74 5320 1 ( ( -LRB- cord-015021-pol2qm74 5320 2 reinfusion reinfusion NN cord-015021-pol2qm74 5320 3 of of IN cord-015021-pol2qm74 5320 4 shed shed JJ cord-015021-pol2qm74 5320 5 blood blood NN cord-015021-pol2qm74 5320 6 ) ) -RRB- cord-015021-pol2qm74 5320 7 . . . cord-015021-pol2qm74 5321 1 Hepatic hepatic JJ cord-015021-pol2qm74 5321 2 ATP ATP NNP cord-015021-pol2qm74 5321 3 levels level NNS cord-015021-pol2qm74 5321 4 declined decline VBD cord-015021-pol2qm74 5321 5 from from IN cord-015021-pol2qm74 5321 6 2.3 2.3 CD cord-015021-pol2qm74 5321 7 + + SYM cord-015021-pol2qm74 5321 8 0.2 0.2 CD cord-015021-pol2qm74 5321 9 txmol txmol RB cord-015021-pol2qm74 5321 10 / / SYM cord-015021-pol2qm74 5321 11 g g NN cord-015021-pol2qm74 5321 12 to to IN cord-015021-pol2qm74 5321 13 0.24_+0.08 0.24_+0.08 CD cord-015021-pol2qm74 5321 14 ( ( -LRB- cord-015021-pol2qm74 5321 15 60 60 CD cord-015021-pol2qm74 5321 16 min min NN cord-015021-pol2qm74 5321 17 shock shock NN cord-015021-pol2qm74 5321 18 ) ) -RRB- cord-015021-pol2qm74 5321 19 indicating indicate VBG cord-015021-pol2qm74 5321 20 severe severe JJ cord-015021-pol2qm74 5321 21 ischemia ischemia NN cord-015021-pol2qm74 5321 22 , , , cord-015021-pol2qm74 5321 23 and and CC cord-015021-pol2qm74 5321 24 recovered recover VBD cord-015021-pol2qm74 5321 25 to to IN cord-015021-pol2qm74 5321 26 1.04 1.04 CD cord-015021-pol2qm74 5321 27 - - HYPH cord-015021-pol2qm74 5321 28 -0.2 -0.2 NN cord-015021-pol2qm74 5321 29 at at IN cord-015021-pol2qm74 5321 30 90 90 CD cord-015021-pol2qm74 5321 31 min min NN cord-015021-pol2qm74 5321 32 RS rs NN cord-015021-pol2qm74 5321 33 . . . cord-015021-pol2qm74 5322 1 To to TO cord-015021-pol2qm74 5322 2 test test VB cord-015021-pol2qm74 5322 3 for for IN cord-015021-pol2qm74 5322 4 potential potential JJ cord-015021-pol2qm74 5322 5 oxidant oxidant JJ cord-015021-pol2qm74 5322 6 stress stress NN cord-015021-pol2qm74 5322 7 during during IN cord-015021-pol2qm74 5322 8 RS rs NN cord-015021-pol2qm74 5322 9 , , , cord-015021-pol2qm74 5322 10 plasma plasma NN cord-015021-pol2qm74 5322 11 GSSG GSSG NNP cord-015021-pol2qm74 5322 12 conc conc NNP cord-015021-pol2qm74 5322 13 . . NNP cord-015021-pol2qm74 5322 14 were be VBD cord-015021-pol2qm74 5322 15 measured measure VBN cord-015021-pol2qm74 5322 16 . . . cord-015021-pol2qm74 5323 1 Although although IN cord-015021-pol2qm74 5323 2 GSSG GSSG NNP cord-015021-pol2qm74 5323 3 levels level NNS cord-015021-pol2qm74 5323 4 increased increase VBD cord-015021-pol2qm74 5323 5 by by IN cord-015021-pol2qm74 5323 6 120 120 CD cord-015021-pol2qm74 5323 7 % % NN cord-015021-pol2qm74 5323 8 compared compare VBN cord-015021-pol2qm74 5323 9 to to IN cord-015021-pol2qm74 5323 10 baseline baseline JJ cord-015021-pol2qm74 5323 11 levels level NNS cord-015021-pol2qm74 5323 12 ( ( -LRB- cord-015021-pol2qm74 5323 13 0.69!-_0.31 0.69!-_0.31 NNP cord-015021-pol2qm74 5323 14 I.tM I.tM NNP cord-015021-pol2qm74 5323 15 ) ) -RRB- cord-015021-pol2qm74 5323 16 , , , cord-015021-pol2qm74 5323 17 there there EX cord-015021-pol2qm74 5323 18 was be VBD cord-015021-pol2qm74 5323 19 no no DT cord-015021-pol2qm74 5323 20 significant significant JJ cord-015021-pol2qm74 5323 21 difference difference NN cord-015021-pol2qm74 5323 22 to to IN cord-015021-pol2qm74 5323 23 shamoperated shamoperated JJ cord-015021-pol2qm74 5323 24 controls control NNS cord-015021-pol2qm74 5323 25 . . . cord-015021-pol2qm74 5324 1 Spontaneous spontaneous JJ cord-015021-pol2qm74 5324 2 superoxide superoxide NN cord-015021-pol2qm74 5324 3 formation formation NN cord-015021-pol2qm74 5324 4 of of IN cord-015021-pol2qm74 5324 5 isolated isolate VBN cord-015021-pol2qm74 5324 6 KC KC NNP cord-015021-pol2qm74 5324 7 was be VBD cord-015021-pol2qm74 5324 8 0.32 0.32 CD cord-015021-pol2qm74 5324 9 + + SYM cord-015021-pol2qm74 5324 10 0.05 0.05 CD cord-015021-pol2qm74 5324 11 nmol nmol JJ cord-015021-pol2qm74 5324 12 O2-/min/10ecells O2-/min/10ecells NNP cord-015021-pol2qm74 5324 13 ( ( -LRB- cord-015021-pol2qm74 5324 14 KC2 KC2 NNP cord-015021-pol2qm74 5324 15 ) ) -RRB- cord-015021-pol2qm74 5324 16 and and CC cord-015021-pol2qm74 5324 17 0.51 0.51 CD cord-015021-pol2qm74 5324 18 + + CD cord-015021-pol2qm74 5324 19 0.11 0.11 CD cord-015021-pol2qm74 5324 20 ( ( -LRB- cord-015021-pol2qm74 5324 21 KC3 KC3 NNP cord-015021-pol2qm74 5324 22 ) ) -RRB- cord-015021-pol2qm74 5324 23 in in IN cord-015021-pol2qm74 5324 24 controls control NNS cord-015021-pol2qm74 5324 25 and and CC cord-015021-pol2qm74 5324 26 did do VBD cord-015021-pol2qm74 5324 27 not not RB cord-015021-pol2qm74 5324 28 change change VB cord-015021-pol2qm74 5324 29 significantly significantly RB cord-015021-pol2qm74 5324 30 after after IN cord-015021-pol2qm74 5324 31 shock shock NN cord-015021-pol2qm74 5324 32 and and CC cord-015021-pol2qm74 5324 33 90 90 CD cord-015021-pol2qm74 5324 34 rain rain NN cord-015021-pol2qm74 5324 35 RS rs NN cord-015021-pol2qm74 5324 36 . . . cord-015021-pol2qm74 5325 1 Addition addition NN cord-015021-pol2qm74 5325 2 of of IN cord-015021-pol2qm74 5325 3 phorbol phorbol NNP cord-015021-pol2qm74 5325 4 ester ester NNP cord-015021-pol2qm74 5325 5 or or CC cord-015021-pol2qm74 5325 6 opsonized opsonize VBN cord-015021-pol2qm74 5325 7 zymosan zymosan NNP cord-015021-pol2qm74 5325 8 to to IN cord-015021-pol2qm74 5325 9 isolated isolate VBN cord-015021-pol2qm74 5325 10 KC KC NNP cord-015021-pol2qm74 5325 11 did do VBD cord-015021-pol2qm74 5325 12 not not RB cord-015021-pol2qm74 5325 13 indicate indicate VB cord-015021-pol2qm74 5325 14 a a DT cord-015021-pol2qm74 5325 15 priming priming NN cord-015021-pol2qm74 5325 16 of of IN cord-015021-pol2qm74 5325 17 these these DT cord-015021-pol2qm74 5325 18 cells cell NNS cord-015021-pol2qm74 5325 19 . . . cord-015021-pol2qm74 5326 1 Conclusion conclusion NN cord-015021-pol2qm74 5326 2 : : : cord-015021-pol2qm74 5327 1 In in IN cord-015021-pol2qm74 5327 2 striking striking JJ cord-015021-pol2qm74 5327 3 contrast contrast NN cord-015021-pol2qm74 5327 4 to to IN cord-015021-pol2qm74 5327 5 our -PRON- PRP$ cord-015021-pol2qm74 5327 6 previous previous JJ cord-015021-pol2qm74 5327 7 findings finding NNS cord-015021-pol2qm74 5327 8 with with IN cord-015021-pol2qm74 5327 9 hepatic hepatic JJ cord-015021-pol2qm74 5327 10 no no DT cord-015021-pol2qm74 5327 11 - - HYPH cord-015021-pol2qm74 5327 12 flow flow NN cord-015021-pol2qm74 5327 13 ischemia ischemia NN cord-015021-pol2qm74 5327 14 , , , cord-015021-pol2qm74 5327 15 there there EX cord-015021-pol2qm74 5327 16 is be VBZ cord-015021-pol2qm74 5327 17 no no DT cord-015021-pol2qm74 5327 18 evidence evidence NN cord-015021-pol2qm74 5327 19 for for IN cord-015021-pol2qm74 5327 20 a a DT cord-015021-pol2qm74 5327 21 significant significant JJ cord-015021-pol2qm74 5327 22 KC KC NNP cord-015021-pol2qm74 5327 23 activation activation NN cord-015021-pol2qm74 5327 24 after after IN cord-015021-pol2qm74 5327 25 60 60 CD cord-015021-pol2qm74 5327 26 min min NN cord-015021-pol2qm74 5327 27 of of IN cord-015021-pol2qm74 5327 28 hemorrhagic hemorrhagic JJ cord-015021-pol2qm74 5327 29 shock shock NN cord-015021-pol2qm74 5327 30 and and CC cord-015021-pol2qm74 5327 31 up up IN cord-015021-pol2qm74 5327 32 to to TO cord-015021-pol2qm74 5327 33 90 90 CD cord-015021-pol2qm74 5327 34 rain rain NN cord-015021-pol2qm74 5327 35 of of IN cord-015021-pol2qm74 5327 36 resuscitation resuscitation NN cord-015021-pol2qm74 5327 37 . . . cord-015021-pol2qm74 5328 1 Objectives objective NNS cord-015021-pol2qm74 5328 2 - - : cord-015021-pol2qm74 5328 3 This this DT cord-015021-pol2qm74 5328 4 study study NN cord-015021-pol2qm74 5328 5 investigates investigate VBZ cord-015021-pol2qm74 5328 6 morphometric morphometric JJ cord-015021-pol2qm74 5328 7 changes change NNS cord-015021-pol2qm74 5328 8 in in IN cord-015021-pol2qm74 5328 9 KC KC NNP cord-015021-pol2qm74 5328 10 nltrastmcture nltrastmcture NN cord-015021-pol2qm74 5328 11 which which WDT cord-015021-pol2qm74 5328 12 might may MD cord-015021-pol2qm74 5328 13 account account VB cord-015021-pol2qm74 5328 14 for for IN cord-015021-pol2qm74 5328 15 this this DT cord-015021-pol2qm74 5328 16 diminution diminution NN cord-015021-pol2qm74 5328 17 in in IN cord-015021-pol2qm74 5328 18 phagacytosis phagacytosis NN cord-015021-pol2qm74 5328 19 . . . cord-015021-pol2qm74 5329 1 Materials material NNS cord-015021-pol2qm74 5329 2 and and CC cord-015021-pol2qm74 5329 3 methods method NNS cord-015021-pol2qm74 5329 4 -Three -Three NNP cord-015021-pol2qm74 5329 5 groups group NNS cord-015021-pol2qm74 5329 6 of of IN cord-015021-pol2qm74 5329 7 Wistar Wistar NNP cord-015021-pol2qm74 5329 8 rats rat NNS cord-015021-pol2qm74 5329 9 were be VBD cord-015021-pol2qm74 5329 10 studied study VBN cord-015021-pol2qm74 5329 11 : : : cord-015021-pol2qm74 5330 1 Control Control NNP cord-015021-pol2qm74 5330 2 , , , cord-015021-pol2qm74 5330 3 Sham Sham NNP cord-015021-pol2qm74 5330 4 - - HYPH cord-015021-pol2qm74 5330 5 operated operate VBD cord-015021-pol2qm74 5330 6 [ [ -LRB- cord-015021-pol2qm74 5330 7 Sham Sham NNP cord-015021-pol2qm74 5330 8 ] ] -RRB- cord-015021-pol2qm74 5330 9 and and CC cord-015021-pol2qm74 5330 10 Bile bile NN cord-015021-pol2qm74 5330 11 duct duct NN cord-015021-pol2qm74 5330 12 ligated ligate VBD cord-015021-pol2qm74 5330 13 [ [ -LRB- cord-015021-pol2qm74 5330 14 EDL EDL NNP cord-015021-pol2qm74 5330 15 ] ] -RRB- cord-015021-pol2qm74 5330 16 . . . cord-015021-pol2qm74 5331 1 After after IN cord-015021-pol2qm74 5331 2 3 3 CD cord-015021-pol2qm74 5331 3 weeks week NNS cord-015021-pol2qm74 5331 4 animals animal NNS cord-015021-pol2qm74 5331 5 were be VBD cord-015021-pol2qm74 5331 6 sacrificed sacrifice VBN cord-015021-pol2qm74 5331 7 and and CC cord-015021-pol2qm74 5331 8 livers liver NNS cord-015021-pol2qm74 5331 9 were be VBD cord-015021-pol2qm74 5331 10 " " `` cord-015021-pol2qm74 5331 11 perfusion perfusion NN cord-015021-pol2qm74 5331 12 fixed fix VBN cord-015021-pol2qm74 5331 13 " " '' cord-015021-pol2qm74 5331 14 with with IN cord-015021-pol2qm74 5331 15 3 3 CD cord-015021-pol2qm74 5331 16 % % NN cord-015021-pol2qm74 5331 17 glntaraldehyde glntaraldehyde NNS cord-015021-pol2qm74 5331 18 and and CC cord-015021-pol2qm74 5331 19 processed process VBN cord-015021-pol2qm74 5331 20 for for IN cord-015021-pol2qm74 5331 21 transmission transmission NN cord-015021-pol2qm74 5331 22 electron electron NN cord-015021-pol2qm74 5331 23 microscopy microscopy NN cord-015021-pol2qm74 5331 24 and and CC cord-015021-pol2qm74 5331 25 image image NN cord-015021-pol2qm74 5331 26 analysis analysis NN cord-015021-pol2qm74 5331 27 . . . cord-015021-pol2qm74 5332 1 Results result NNS cord-015021-pol2qm74 5332 2 -In -In . cord-015021-pol2qm74 5333 1 the the DT cord-015021-pol2qm74 5333 2 the the DT cord-015021-pol2qm74 5333 3 BDL BDL NNP cord-015021-pol2qm74 5333 4 group group NN cord-015021-pol2qm74 5333 5 Kupffer Kupffer NNP cord-015021-pol2qm74 5333 6 cell cell NN cord-015021-pol2qm74 5333 7 numbers number NNS cord-015021-pol2qm74 5333 8 were be VBD cord-015021-pol2qm74 5333 9 greatly greatly RB cord-015021-pol2qm74 5333 10 increased increase VBN cord-015021-pol2qm74 5333 11 . . . cord-015021-pol2qm74 5334 1 Biliary Biliary NNP cord-015021-pol2qm74 5334 2 ductular ductular JJ cord-015021-pol2qm74 5334 3 proliferation proliferation NN cord-015021-pol2qm74 5334 4 was be VBD cord-015021-pol2qm74 5334 5 evident evident JJ cord-015021-pol2qm74 5334 6 and and CC cord-015021-pol2qm74 5334 7 sinusoidal sinusoidal JJ cord-015021-pol2qm74 5334 8 spaces space NNS cord-015021-pol2qm74 5334 9 were be VBD cord-015021-pol2qm74 5334 10 compromised compromise VBN cord-015021-pol2qm74 5334 11 . . . cord-015021-pol2qm74 5335 1 Eleven eleven CD cord-015021-pol2qm74 5335 2 nuclear nuclear JJ cord-015021-pol2qm74 5335 3 and and CC cord-015021-pol2qm74 5335 4 cytoplasmic cytoplasmic JJ cord-015021-pol2qm74 5335 5 parameters parameter NNS cord-015021-pol2qm74 5335 6 were be VBD cord-015021-pol2qm74 5335 7 measured measure VBN cord-015021-pol2qm74 5335 8 and and CC cord-015021-pol2qm74 5335 9 statistically statistically RB cord-015021-pol2qm74 5335 10 significant significant JJ cord-015021-pol2qm74 5335 11 results result NNS cord-015021-pol2qm74 5335 12 are be VBP cord-015021-pol2qm74 5335 13 summarised summarise VBN cord-015021-pol2qm74 5335 14 in in IN cord-015021-pol2qm74 5335 15 the the DT cord-015021-pol2qm74 5335 16 RESULTS result NNS cord-015021-pol2qm74 5335 17 : : : cord-015021-pol2qm74 5335 18 Ascorbic ascorbic NN cord-015021-pol2qm74 5335 19 acid acid NN cord-015021-pol2qm74 5335 20 levels level NNS cord-015021-pol2qm74 5335 21 were be VBD cord-015021-pol2qm74 5335 22 slightly slightly RB cord-015021-pol2qm74 5335 23 elevated elevated JJ cord-015021-pol2qm74 5335 24 after after IN cord-015021-pol2qm74 5335 25 the the DT cord-015021-pol2qm74 5335 26 HS HS NNP cord-015021-pol2qm74 5335 27 and and CC cord-015021-pol2qm74 5335 28 returned return VBD cord-015021-pol2qm74 5335 29 to to IN cord-015021-pol2qm74 5335 30 basal basal NN cord-015021-pol2qm74 5335 31 values value NNS cord-015021-pol2qm74 5335 32 after after IN cord-015021-pol2qm74 5335 33 120 120 CD cord-015021-pol2qm74 5335 34 rain rain NN cord-015021-pol2qm74 5335 35 . . . cord-015021-pol2qm74 5336 1 Glutathione glutathione NN cord-015021-pol2qm74 5336 2 concentrations concentration NNS cord-015021-pol2qm74 5336 3 were be VBD cord-015021-pol2qm74 5336 4 increased increase VBN cord-015021-pol2qm74 5336 5 significantly significantly RB cord-015021-pol2qm74 5336 6 after after IN cord-015021-pol2qm74 5336 7 the the DT cord-015021-pol2qm74 5336 8 HS HS NNP cord-015021-pol2qm74 5336 9 and and CC cord-015021-pol2qm74 5336 10 the the DT cord-015021-pol2qm74 5336 11 GSH GSH NNP cord-015021-pol2qm74 5336 12 levels level NNS cord-015021-pol2qm74 5336 13 kept keep VBD cord-015021-pol2qm74 5336 14 rising rise VBG cord-015021-pol2qm74 5336 15 continuously continuously RB cord-015021-pol2qm74 5336 16 to to IN cord-015021-pol2qm74 5336 17 as as RB cord-015021-pol2qm74 5336 18 much much JJ cord-015021-pol2qm74 5336 19 as as IN cord-015021-pol2qm74 5336 20 4-fold 4-fold CD cord-015021-pol2qm74 5336 21 of of IN cord-015021-pol2qm74 5336 22 basal basal NN cord-015021-pol2qm74 5336 23 levels level NNS cord-015021-pol2qm74 5336 24 at at IN cord-015021-pol2qm74 5336 25 the the DT cord-015021-pol2qm74 5336 26 end end NN cord-015021-pol2qm74 5336 27 of of IN cord-015021-pol2qm74 5336 28 120 120 CD cord-015021-pol2qm74 5336 29 min min NN cord-015021-pol2qm74 5336 30 . . . cord-015021-pol2qm74 5337 1 MDA MDA NNP cord-015021-pol2qm74 5337 2 showed show VBD cord-015021-pol2qm74 5337 3 no no DT cord-015021-pol2qm74 5337 4 significant significant JJ cord-015021-pol2qm74 5337 5 variation variation NN cord-015021-pol2qm74 5337 6 before before IN cord-015021-pol2qm74 5337 7 and and CC cord-015021-pol2qm74 5337 8 after after IN cord-015021-pol2qm74 5337 9 the the DT cord-015021-pol2qm74 5337 10 hemorrhagic hemorrhagic JJ cord-015021-pol2qm74 5337 11 shock shock NN cord-015021-pol2qm74 5337 12 . . . cord-015021-pol2qm74 5338 1 Plasma plasma NN cord-015021-pol2qm74 5338 2 concentrations concentration NNS cord-015021-pol2qm74 5338 3 of of IN cord-015021-pol2qm74 5338 4 ratine ratine NN cord-015021-pol2qm74 5338 5 , , , cord-015021-pol2qm74 5338 6 teucine teucine NNP cord-015021-pol2qm74 5338 7 , , , cord-015021-pol2qm74 5338 8 isoleucine isoleucine NNP cord-015021-pol2qm74 5338 9 , , , cord-015021-pol2qm74 5338 10 phenylalanine phenylalanine NN cord-015021-pol2qm74 5338 11 , , , cord-015021-pol2qm74 5338 12 proline proline NN cord-015021-pol2qm74 5338 13 , , , cord-015021-pol2qm74 5338 14 threonine threonine NN cord-015021-pol2qm74 5338 15 and and CC cord-015021-pol2qm74 5338 16 serine serine NN cord-015021-pol2qm74 5338 17 showed show VBD cord-015021-pol2qm74 5338 18 significant significant JJ cord-015021-pol2qm74 5338 19 increase increase NN cord-015021-pol2qm74 5338 20 over over IN cord-015021-pol2qm74 5338 21 basal basal NN cord-015021-pol2qm74 5338 22 levels level NNS cord-015021-pol2qm74 5338 23 during during IN cord-015021-pol2qm74 5338 24 the the DT cord-015021-pol2qm74 5338 25 whole whole JJ cord-015021-pol2qm74 5338 26 ischemic ischemic JJ cord-015021-pol2qm74 5338 27 period period NN cord-015021-pol2qm74 5338 28 . . . cord-015021-pol2qm74 5339 1 Glutamic glutamic NN cord-015021-pol2qm74 5339 2 acid acid NN cord-015021-pol2qm74 5339 3 was be VBD cord-015021-pol2qm74 5339 4 slightly slightly RB cord-015021-pol2qm74 5339 5 elevated elevated JJ cord-015021-pol2qm74 5339 6 at at IN cord-015021-pol2qm74 5339 7 the the DT cord-015021-pol2qm74 5339 8 onset onset NN cord-015021-pol2qm74 5339 9 of of IN cord-015021-pol2qm74 5339 10 HS HS NNP cord-015021-pol2qm74 5339 11 and and CC cord-015021-pol2qm74 5339 12 remained remain VBD cord-015021-pol2qm74 5339 13 the the DT cord-015021-pol2qm74 5339 14 same same JJ cord-015021-pol2qm74 5339 15 for for IN cord-015021-pol2qm74 5339 16 the the DT cord-015021-pol2qm74 5339 17 rest rest NN cord-015021-pol2qm74 5339 18 of of IN cord-015021-pol2qm74 5339 19 ischemic ischemic JJ cord-015021-pol2qm74 5339 20 period period NN cord-015021-pol2qm74 5339 21 . . . cord-015021-pol2qm74 5340 1 Hydroxyproline Hydroxyproline NNP cord-015021-pol2qm74 5340 2 was be VBD cord-015021-pol2qm74 5340 3 significantly significantly RB cord-015021-pol2qm74 5340 4 below below IN cord-015021-pol2qm74 5340 5 the the DT cord-015021-pol2qm74 5340 6 basal basal NN cord-015021-pol2qm74 5340 7 value value NN cord-015021-pol2qm74 5340 8 at at IN cord-015021-pol2qm74 5340 9 the the DT cord-015021-pol2qm74 5340 10 mid mid JJ cord-015021-pol2qm74 5340 11 - - NN cord-015021-pol2qm74 5340 12 point point NN cord-015021-pol2qm74 5340 13 of of IN cord-015021-pol2qm74 5340 14 ischemic ischemic JJ cord-015021-pol2qm74 5340 15 period period NN cord-015021-pol2qm74 5340 16 . . . cord-015021-pol2qm74 5341 1 Alanine alanine NN cord-015021-pol2qm74 5341 2 , , , cord-015021-pol2qm74 5341 3 glycine glycine NN cord-015021-pol2qm74 5341 4 , , , cord-015021-pol2qm74 5341 5 histidine histidine NN cord-015021-pol2qm74 5341 6 and and CC cord-015021-pol2qm74 5341 7 aspartate aspartate NN cord-015021-pol2qm74 5341 8 did do VBD cord-015021-pol2qm74 5341 9 not not RB cord-015021-pol2qm74 5341 10 change change VB cord-015021-pol2qm74 5341 11 significantly significantly RB cord-015021-pol2qm74 5341 12 throughout throughout IN cord-015021-pol2qm74 5341 13 experimental experimental JJ cord-015021-pol2qm74 5341 14 time time NN cord-015021-pol2qm74 5341 15 course course NN cord-015021-pol2qm74 5341 16 . . . cord-015021-pol2qm74 5342 1 CONCLUSIONS conclusion NNS cord-015021-pol2qm74 5342 2 : : : cord-015021-pol2qm74 5342 3 ( ( -LRB- cord-015021-pol2qm74 5342 4 1 1 LS cord-015021-pol2qm74 5342 5 ) ) -RRB- cord-015021-pol2qm74 5343 1 Oxidative oxidative JJ cord-015021-pol2qm74 5343 2 stress stress NN cord-015021-pol2qm74 5343 3 might may MD cord-015021-pol2qm74 5343 4 not not RB cord-015021-pol2qm74 5343 5 be be VB cord-015021-pol2qm74 5343 6 severe severe JJ cord-015021-pol2qm74 5343 7 in in IN cord-015021-pol2qm74 5343 8 the the DT cord-015021-pol2qm74 5343 9 systemic systemic JJ cord-015021-pol2qm74 5343 10 hemorrhagic hemorrhagic JJ cord-015021-pol2qm74 5343 11 shock shock NN cord-015021-pol2qm74 5343 12 for for IN cord-015021-pol2qm74 5343 13 pigs pig NNS cord-015021-pol2qm74 5343 14 since since IN cord-015021-pol2qm74 5343 15 no no DT cord-015021-pol2qm74 5343 16 significant significant JJ cord-015021-pol2qm74 5343 17 variations variation NNS cord-015021-pol2qm74 5343 18 were be VBD cord-015021-pol2qm74 5343 19 observed observe VBN cord-015021-pol2qm74 5343 20 for for IN cord-015021-pol2qm74 5343 21 ascorbic ascorbic NN cord-015021-pol2qm74 5343 22 acid acid NN cord-015021-pol2qm74 5343 23 and and CC cord-015021-pol2qm74 5343 24 MDA MDA NNP cord-015021-pol2qm74 5343 25 ( ( -LRB- cord-015021-pol2qm74 5343 26 2 2 CD cord-015021-pol2qm74 5343 27 ) ) -RRB- cord-015021-pol2qm74 5344 1 the the DT cord-015021-pol2qm74 5344 2 increase increase NN cord-015021-pol2qm74 5344 3 of of IN cord-015021-pol2qm74 5344 4 GSH GSH NNP cord-015021-pol2qm74 5344 5 might may MD cord-015021-pol2qm74 5344 6 be be VB cord-015021-pol2qm74 5344 7 that that IN cord-015021-pol2qm74 5344 8 it -PRON- PRP cord-015021-pol2qm74 5344 9 was be VBD cord-015021-pol2qm74 5344 10 released release VBN cord-015021-pol2qm74 5344 11 from from IN cord-015021-pol2qm74 5344 12 hepatocytes hepatocyte NNS cord-015021-pol2qm74 5344 13 when when WRB cord-015021-pol2qm74 5344 14 the the DT cord-015021-pol2qm74 5344 15 animal animal NN cord-015021-pol2qm74 5344 16 was be VBD cord-015021-pol2qm74 5344 17 under under IN cord-015021-pol2qm74 5344 18 systemic systemic JJ cord-015021-pol2qm74 5344 19 ischemia ischemia NN cord-015021-pol2qm74 5344 20 . . . cord-015021-pol2qm74 5345 1 ( ( -LRB- cord-015021-pol2qm74 5345 2 3 3 LS cord-015021-pol2qm74 5345 3 ) ) -RRB- cord-015021-pol2qm74 5346 1 Celzain Celzain NNP cord-015021-pol2qm74 5346 2 amino amino NN cord-015021-pol2qm74 5346 3 acids acid NNS cord-015021-pol2qm74 5346 4 might may MD cord-015021-pol2qm74 5346 5 be be VB cord-015021-pol2qm74 5346 6 acting act VBG cord-015021-pol2qm74 5346 7 as as IN cord-015021-pol2qm74 5346 8 transmitters transmitter NNS cord-015021-pol2qm74 5346 9 in in IN cord-015021-pol2qm74 5346 10 the the DT cord-015021-pol2qm74 5346 11 event event NN cord-015021-pol2qm74 5346 12 of of IN cord-015021-pol2qm74 5346 13 ischemia ischemia NN cord-015021-pol2qm74 5346 14 . . . cord-015021-pol2qm74 5347 1 However however RB cord-015021-pol2qm74 5347 2 , , , cord-015021-pol2qm74 5347 3 fm"lher fm"lher NN cord-015021-pol2qm74 5347 4 investigations investigation NNS cord-015021-pol2qm74 5347 5 are be VBP cord-015021-pol2qm74 5347 6 needed need VBN cord-015021-pol2qm74 5347 7 to to TO cord-015021-pol2qm74 5347 8 clarify clarify VB cord-015021-pol2qm74 5347 9 the the DT cord-015021-pol2qm74 5347 10 detailed detailed JJ cord-015021-pol2qm74 5347 11 mechanism mechanism NN cord-015021-pol2qm74 5347 12 in in IN cord-015021-pol2qm74 5347 13 regard regard NN cord-015021-pol2qm74 5347 14 with with IN cord-015021-pol2qm74 5347 15 antioxidants antioxidant NNS cord-015021-pol2qm74 5347 16 and and CC cord-015021-pol2qm74 5347 17 amino amino JJ cord-015021-pol2qm74 5347 18 acids acid NNS cord-015021-pol2qm74 5347 19 . . . cord-015021-pol2qm74 5348 1 Dr. Dr. NNP cord-015021-pol2qm74 5348 2 Fang Fang NNP cord-015021-pol2qm74 5348 3 - - HYPH cord-015021-pol2qm74 5348 4 Ku Ku NNP cord-015021-pol2qm74 5348 5 P'eng P'eng NNP cord-015021-pol2qm74 5348 6 Taichung Taichung NNP cord-015021-pol2qm74 5348 7 Veterans Veterans NNPS cord-015021-pol2qm74 5348 8 General General NNP cord-015021-pol2qm74 5348 9 Hospital Hospital NNP cord-015021-pol2qm74 5348 10 Talchung Talchung NNP cord-015021-pol2qm74 5348 11 , , , cord-015021-pol2qm74 5348 12 TAIWAN TAIWAN NNP cord-015021-pol2qm74 5348 13 407 407 CD cord-015021-pol2qm74 5348 14 , , , cord-015021-pol2qm74 5349 1 R.O.C. R.O.C. NNP cord-015021-pol2qm74 5349 2 Jia Jia NNP cord-015021-pol2qm74 5349 3 Shi Shi NNP cord-015021-pol2qm74 5349 4 Yong Yong NNP cord-015021-pol2qm74 5349 5 , , , cord-015021-pol2qm74 5349 6 Huang Huang NNP cord-015021-pol2qm74 5349 7 Zhi Zhi NNP cord-015021-pol2qm74 5349 8 Oiang Oiang NNP cord-015021-pol2qm74 5349 9 and and CC cord-015021-pol2qm74 5350 1 Men man NNS cord-015021-pol2qm74 5350 2 xian xian NNP cord-015021-pol2qm74 5350 3 Jun. June NNP cord-015021-pol2qm74 5351 1 In in IN cord-015021-pol2qm74 5351 2 patients patient NNS cord-015021-pol2qm74 5351 3 underi~ underi~ VBP cord-015021-pol2qm74 5352 1 ent ent NNP cord-015021-pol2qm74 5352 2 major major JJ cord-015021-pol2qm74 5352 3 hepatic hepatic JJ cord-015021-pol2qm74 5352 4 surgery surgery NN cord-015021-pol2qm74 5352 5 , , , cord-015021-pol2qm74 5352 6 obstructive obstructive JJ cord-015021-pol2qm74 5352 7 jaundice jaundice NN cord-015021-pol2qm74 5352 8 has have VBZ cord-015021-pol2qm74 5352 9 been be VBN cord-015021-pol2qm74 5352 10 implicated implicate VBN cord-015021-pol2qm74 5352 11 with with IN cord-015021-pol2qm74 5352 12 fnoreased fnoreased JJ cord-015021-pol2qm74 5352 13 susceptibility susceptibility NN cord-015021-pol2qm74 5352 14 to to IN cord-015021-pol2qm74 5352 15 sepsis sepsis NN cord-015021-pol2qm74 5352 16 and and CC cord-015021-pol2qm74 5352 17 liver liver NN cord-015021-pol2qm74 5352 18 failure failure NN cord-015021-pol2qm74 5352 19 . . . cord-015021-pol2qm74 5353 1 Jaundice jaundice NN cord-015021-pol2qm74 5353 2 was be VBD cord-015021-pol2qm74 5353 3 said say VBN cord-015021-pol2qm74 5353 4 to to IN cord-015021-pol2qm74 5353 5 he -PRON- PRP cord-015021-pol2qm74 5353 6 associated associate VBD cord-015021-pol2qm74 5353 7 with with IN cord-015021-pol2qm74 5353 8 derangement derangement NN cord-015021-pol2qm74 5353 9 of of IN cord-015021-pol2qm74 5353 10 iamune iamune JJ cord-015021-pol2qm74 5353 11 function function NN cord-015021-pol2qm74 5353 12 and and CC cord-015021-pol2qm74 5353 13 result result VB cord-015021-pol2qm74 5353 14 in in IN cord-015021-pol2qm74 5353 15 expression expression NN cord-015021-pol2qm74 5353 16 of of IN cord-015021-pol2qm74 5353 17 pr,:.inflar pr,:.inflar CD cord-015021-pol2qm74 5353 18 ... ... : cord-015021-pol2qm74 5353 19 aatory aatory NNP cord-015021-pol2qm74 5353 20 cytoki~ cytoki~ . cord-015021-pol2qm74 5354 1 es es XX cord-015021-pol2qm74 5354 2 that that DT cord-015021-pol2qm74 5354 3 cause cause VBP cord-015021-pol2qm74 5354 4 hepatooellular hepatooellular NNP cord-015021-pol2qm74 5354 5 damage damage NN cord-015021-pol2qm74 5354 6 . . . cord-015021-pol2qm74 5355 1 This this DT cord-015021-pol2qm74 5355 2 study study NN cord-015021-pol2qm74 5355 3 is be VBZ cord-015021-pol2qm74 5355 4 ~.o ~.o NNP cord-015021-pol2qm74 5355 5 investigate investigate VB cord-015021-pol2qm74 5355 6 the the DT cord-015021-pol2qm74 5355 7 effects effect NNS cord-015021-pol2qm74 5355 8 , , , cord-015021-pol2qm74 5355 9 .,t .,t NNP cord-015021-pol2qm74 5355 10 lip,~polysaccharide(LPS)rats lip,~polysaccharide(LPS)rats NNP cord-015021-pol2qm74 5355 11 . . . cord-015021-pol2qm74 5356 1 Jaundice jaundice NN cord-015021-pol2qm74 5356 2 were be VBD cord-015021-pol2qm74 5356 3 produced produce VBN cord-015021-pol2qm74 5356 4 in in IN cord-015021-pol2qm74 5356 5 healthy healthy JJ cord-015021-pol2qm74 5356 6 ~istar ~istar CD cord-015021-pol2qm74 5356 7 rats rat NNS cord-015021-pol2qm74 5356 8 of of IN cord-015021-pol2qm74 5356 9 either either DT cord-015021-pol2qm74 5356 10 sex sex NN cord-015021-pol2qm74 5356 11 weighing weigh VBG cord-015021-pol2qm74 5356 12 180 180 CD cord-015021-pol2qm74 5356 13 - - SYM cord-015021-pol2qm74 5356 14 220 220 CD cord-015021-pol2qm74 5356 15 m~ m~ XX cord-015021-pol2qm74 5356 16 by by IN cord-015021-pol2qm74 5356 17 common common JJ cord-015021-pol2qm74 5356 18 hi hi UH cord-015021-pol2qm74 5356 19 l~ l~ XX cord-015021-pol2qm74 5357 1 duet duet NNP cord-015021-pol2qm74 5357 2 l l NNP cord-015021-pol2qm74 5358 1 igation(Bl)L).Seven igation(Bl)L).Seven NNP cord-015021-pol2qm74 5358 2 days day NNS cord-015021-pol2qm74 5358 3 post post NNP cord-015021-pol2qm74 5358 4 l l NNP cord-015021-pol2qm74 5358 5 igation igation NN cord-015021-pol2qm74 5358 6 , , , cord-015021-pol2qm74 5358 7 rats rat NNS cord-015021-pol2qm74 5358 8 were be VBD cord-015021-pol2qm74 5358 9 given give VBN cord-015021-pol2qm74 5358 10 LPS(236.gg.10)0.7rag LPS(236.gg.10)0.7rag NNP cord-015021-pol2qm74 5359 1 /kg /kg NFP cord-015021-pol2qm74 5359 2 intraperitoneally intraperitoneally RB cord-015021-pol2qm74 5359 3 . . . cord-015021-pol2qm74 5360 1 At at IN cord-015021-pol2qm74 5360 2 the the DT cord-015021-pol2qm74 5360 3 end end NN cord-015021-pol2qm74 5360 4 , , , cord-015021-pol2qm74 5360 5 : : : cord-015021-pol2qm74 5360 6 , , , cord-015021-pol2qm74 5360 7 f f NNP cord-015021-pol2qm74 5360 8 l l NNP cord-015021-pol2qm74 5360 9 , , , cord-015021-pol2qm74 5360 10 gand gand NNP cord-015021-pol2qm74 5360 11 5 5 CD cord-015021-pol2qm74 5360 12 hours hour NNS cord-015021-pol2qm74 5360 13 after after IN cord-015021-pol2qm74 5360 14 LP$ LP$ NNP cord-015021-pol2qm74 5360 15 ehanllenge ehanllenge NN cord-015021-pol2qm74 5360 16 , , , cord-015021-pol2qm74 5360 17 liver liver NN cord-015021-pol2qm74 5360 18 were be VBD cord-015021-pol2qm74 5360 19 removed remove VBN cord-015021-pol2qm74 5360 20 and and CC cord-015021-pol2qm74 5360 21 prepared prepare VBN cord-015021-pol2qm74 5360 22 for for IN cord-015021-pol2qm74 5360 23 forzen forzen NN cord-015021-pol2qm74 5360 24 sections section NNS cord-015021-pol2qm74 5360 25 immediately immediately RB cord-015021-pol2qm74 5360 26 . . . cord-015021-pol2qm74 5361 1 I)emonstration i)emonstration NN cord-015021-pol2qm74 5361 2 of of IN cord-015021-pol2qm74 5361 3 INF INF NNP cord-015021-pol2qm74 5361 4 in in IN cord-015021-pol2qm74 5361 5 liver liver NN cord-015021-pol2qm74 5361 6 parenchyna parenchyna NN cord-015021-pol2qm74 5361 7 were be VBD cord-015021-pol2qm74 5361 8 performed perform VBN cord-015021-pol2qm74 5361 9 by by IN cord-015021-pol2qm74 5361 10 method method NN cord-015021-pol2qm74 5361 11 of of IN cord-015021-pol2qm74 5361 12 ABU ABU NNP cord-015021-pol2qm74 5362 1 i i PRP cord-015021-pol2qm74 5362 2 ~ ~ NFP cord-015021-pol2qm74 5362 3 munohistochemistry munohistochemistry NNP cord-015021-pol2qm74 5362 4 using use VBG cord-015021-pol2qm74 5362 5 r r NNP cord-015021-pol2qm74 5362 6 ~ ~ CD cord-015021-pol2qm74 5362 7 onoolonal onoolonal JJ cord-015021-pol2qm74 5362 8 antibody antibody NN cord-015021-pol2qm74 5362 9 against against IN cord-015021-pol2qm74 5362 10 TNF TNF NNP cord-015021-pol2qm74 5362 11 , , , cord-015021-pol2qm74 5362 12 Leve Leve NNP cord-015021-pol2qm74 5362 13 of of IN cord-015021-pol2qm74 5362 14 mRNA mRNA NNP cord-015021-pol2qm74 5362 15 for for IN cord-015021-pol2qm74 5362 16 TNF TNF NNP cord-015021-pol2qm74 5363 1 ~ere ~ere NNP cord-015021-pol2qm74 5363 2 measured measure VBN cord-015021-pol2qm74 5363 3 by by IN cord-015021-pol2qm74 5363 4 in in IN cord-015021-pol2qm74 5363 5 - - HYPH cord-015021-pol2qm74 5363 6 situ situ NN cord-015021-pol2qm74 5363 7 hybridization hybridization NN cord-015021-pol2qm74 5363 8 using use VBG cord-015021-pol2qm74 5363 9 biotin biotin NN cord-015021-pol2qm74 5363 10 - - HYPH cord-015021-pol2qm74 5363 11 labeled label VBN cord-015021-pol2qm74 5363 12 eDNA edna NN cord-015021-pol2qm74 5363 13 probe probe NN cord-015021-pol2qm74 5363 14 . . . cord-015021-pol2qm74 5364 1 Results result NNS cord-015021-pol2qm74 5364 2 sho'~ed sho'~ed NNP cord-015021-pol2qm74 5364 3 that that IN cord-015021-pol2qm74 5364 4 TNF TNF NNP cord-015021-pol2qm74 5364 5 stained stain VBN cord-015021-pol2qm74 5364 6 granules granule NNS cord-015021-pol2qm74 5364 7 appeared appear VBD cord-015021-pol2qm74 5364 8 in in IN cord-015021-pol2qm74 5364 9 kup~'fer kup~'fer NNP cord-015021-pol2qm74 5364 10 eell~ eell~ NNPS cord-015021-pol2qm74 5364 11 and and CC cord-015021-pol2qm74 5364 12 polymorphonuclear polymorphonuclear NNP cord-015021-pol2qm74 5364 13 leukocytes(PNNl leukocytes(PNNl NNP cord-015021-pol2qm74 5364 14 , , , cord-015021-pol2qm74 5364 15 but but CC cord-015021-pol2qm74 5364 16 not not RB cord-015021-pol2qm74 5364 17 in in IN cord-015021-pol2qm74 5364 18 hepatoeytes hepatoeyte NNS cord-015021-pol2qm74 5364 19 nor nor CC cord-015021-pol2qm74 5364 20 endothelial endothelial JJ cord-015021-pol2qm74 5364 21 eel eel NN cord-015021-pol2qm74 5364 22 Is be VBZ cord-015021-pol2qm74 5364 23 . . . cord-015021-pol2qm74 5365 1 They -PRON- PRP cord-015021-pol2qm74 5365 2 ~'ere ~'ere RB cord-015021-pol2qm74 5365 3 located locate VBN cord-015021-pol2qm74 5365 4 within within IN cord-015021-pol2qm74 5365 5 cytoplasms cytoplasm NNS cord-015021-pol2qm74 5365 6 and and CC cord-015021-pol2qm74 5365 7 peaked peak VBD cord-015021-pol2qm74 5365 8 at at IN cord-015021-pol2qm74 5365 9 3 3 CD cord-015021-pol2qm74 5365 10 - - SYM cord-015021-pol2qm74 5365 11 5 5 CD cord-015021-pol2qm74 5365 12 hours hour NNS cord-015021-pol2qm74 5365 13 after after IN cord-015021-pol2qm74 5365 14 LPS LPS NNP cord-015021-pol2qm74 5365 15 ohal ohal NN cord-015021-pol2qm74 5365 16 lenge lenge NNP cord-015021-pol2qm74 5365 17 . . . cord-015021-pol2qm74 5366 1 There there EX cord-015021-pol2qm74 5366 2 was be VBD cord-015021-pol2qm74 5366 3 vocomitant vocomitant JJ cord-015021-pol2qm74 5366 4 TNFmRNA tnfmrna NN cord-015021-pol2qm74 5366 5 expression expression NN cord-015021-pol2qm74 5366 6 but but CC cord-015021-pol2qm74 5366 7 peaked peak VBD cord-015021-pol2qm74 5366 8 earlier early JJR cord-015021-pol2qm74 5366 9 1 1 CD cord-015021-pol2qm74 5366 10 hour hour NN cord-015021-pol2qm74 5366 11 post post NN cord-015021-pol2qm74 5366 12 LPS lps NN cord-015021-pol2qm74 5366 13 challenge challenge NN cord-015021-pol2qm74 5366 14 . . . cord-015021-pol2qm74 5367 1 TNFmRNA TNFmRNA NNP cord-015021-pol2qm74 5367 2 vcere vcere NNP cord-015021-pol2qm74 5367 3 detected detect VBN cord-015021-pol2qm74 5367 4 notably notably RB cord-015021-pol2qm74 5367 5 in in IN cord-015021-pol2qm74 5367 6 necrotic necrotic JJ cord-015021-pol2qm74 5367 7 area area NN cord-015021-pol2qm74 5367 8 and and CC cord-015021-pol2qm74 5367 9 barely barely RB cord-015021-pol2qm74 5367 10 in in IN cord-015021-pol2qm74 5367 11 BDL BDL NNP cord-015021-pol2qm74 5367 12 rats rat NNS cord-015021-pol2qm74 5368 1 ~ithout ~ithout JJ cord-015021-pol2qm74 5369 1 LPS LPS NNP cord-015021-pol2qm74 5369 2 challenge challenge NN cord-015021-pol2qm74 5369 3 . . . cord-015021-pol2qm74 5370 1 It -PRON- PRP cord-015021-pol2qm74 5370 2 is be VBZ cord-015021-pol2qm74 5370 3 therefore therefore RB cord-015021-pol2qm74 5370 4 postulated postulate VBN cord-015021-pol2qm74 5370 5 that that IN cord-015021-pol2qm74 5370 6 production production NN cord-015021-pol2qm74 5370 7 of of IN cord-015021-pol2qm74 5370 8 TNF TNF NNP cord-015021-pol2qm74 5370 9 by by IN cord-015021-pol2qm74 5370 10 inflammatory inflammatory JJ cord-015021-pol2qm74 5370 11 effeetor effeetor NN cord-015021-pol2qm74 5370 12 cells cell NNS cord-015021-pol2qm74 5370 13 - - HYPH cord-015021-pol2qm74 5370 14 kupffer kupffer NN cord-015021-pol2qm74 5370 15 cell cell NN cord-015021-pol2qm74 5370 16 and and CC cord-015021-pol2qm74 5370 17 PHN PHN NNP cord-015021-pol2qm74 5370 18 in in IN cord-015021-pol2qm74 5370 19 site site NN cord-015021-pol2qm74 5370 20 , , , cord-015021-pol2qm74 5370 21 in in IN cord-015021-pol2qm74 5370 22 the the DT cord-015021-pol2qm74 5370 23 obstructive obstructive JJ cord-015021-pol2qm74 5370 24 jaundice jaundice NN cord-015021-pol2qm74 5370 25 rats rat NNS cord-015021-pol2qm74 5370 26 during during IN cord-015021-pol2qm74 5370 27 sepsis sepsis NN cord-015021-pol2qm74 5370 28 may may MD cord-015021-pol2qm74 5370 29 atribute atribute VB cord-015021-pol2qm74 5370 30 to to IN cord-015021-pol2qm74 5370 31 the the DT cord-015021-pol2qm74 5370 32 hepatocellular hepatocellular JJ cord-015021-pol2qm74 5370 33 damage damage NN cord-015021-pol2qm74 5370 34 . . . cord-015021-pol2qm74 5371 1 It -PRON- PRP cord-015021-pol2qm74 5371 2 also also RB cord-015021-pol2qm74 5371 3 provide provide VBP cord-015021-pol2qm74 5371 4 evidence evidence NN cord-015021-pol2qm74 5371 5 for for IN cord-015021-pol2qm74 5371 6 the the DT cord-015021-pol2qm74 5371 7 beneficial beneficial JJ cord-015021-pol2qm74 5371 8 effects effect NNS cord-015021-pol2qm74 5371 9 of of IN cord-015021-pol2qm74 5371 10 early early JJ cord-015021-pol2qm74 5371 11 release release NN cord-015021-pol2qm74 5371 12 of of IN cord-015021-pol2qm74 5371 13 biliary biliary JJ cord-015021-pol2qm74 5371 14 obstruction obstruction NN cord-015021-pol2qm74 5371 15 . . . cord-015021-pol2qm74 5372 1 In in IN cord-015021-pol2qm74 5372 2 the the DT cord-015021-pol2qm74 5372 3 present present JJ cord-015021-pol2qm74 5372 4 study study NN cord-015021-pol2qm74 5372 5 , , , cord-015021-pol2qm74 5372 6 an an DT cord-015021-pol2qm74 5372 7 animal animal NN cord-015021-pol2qm74 5372 8 model model NN cord-015021-pol2qm74 5372 9 of of IN cord-015021-pol2qm74 5372 10 A0C a0c NN cord-015021-pol2qm74 5372 11 in in IN cord-015021-pol2qm74 5372 12 Wlstar Wlstar NNP cord-015021-pol2qm74 5372 13 rats rat NNS cord-015021-pol2qm74 5372 14 was be VBD cord-015021-pol2qm74 5372 15 developed develop VBN cord-015021-pol2qm74 5372 16 by by IN cord-015021-pol2qm74 5372 17 tigatlng tigatlng NNP cord-015021-pol2qm74 5372 18 the the DT cord-015021-pol2qm74 5372 19 common common JJ cord-015021-pol2qm74 5372 20 bite bite NN cord-015021-pol2qm74 5372 21 duct duct NN cord-015021-pol2qm74 5372 22 and and CC cord-015021-pol2qm74 5372 23 injecting inject VBG cord-015021-pol2qm74 5372 24 D.3mt D.3mt NNP cord-015021-pol2qm74 5372 25 solution solution NN cord-015021-pol2qm74 5372 26 of of IN cord-015021-pol2qm74 5372 27 E. E. NNP cord-015021-pol2qm74 5372 28 goli goli NNP cord-015021-pol2qm74 5372 29 % % NN cord-015021-pol2qm74 5372 30 B B NNP cord-015021-pol2qm74 5372 31 , , , cord-015021-pol2qm74 5372 32 ( ( -LRB- cord-015021-pol2qm74 5372 33 g×10 g×10 NNP cord-015021-pol2qm74 5372 34 ' ' POS cord-015021-pol2qm74 5372 35 efm efm NNP cord-015021-pol2qm74 5372 36 / / SYM cord-015021-pol2qm74 5372 37 mt mt NNP cord-015021-pol2qm74 5372 38 ) ) -RRB- cord-015021-pol2qm74 5372 39 into into IN cord-015021-pol2qm74 5372 40 the the DT cord-015021-pol2qm74 5372 41 bite bite NN cord-015021-pol2qm74 5372 42 duct duct NN cord-015021-pol2qm74 5372 43 . . . cord-015021-pol2qm74 5373 1 The the DT cord-015021-pol2qm74 5373 2 mortality mortality NN cord-015021-pol2qm74 5373 3 rate rate NN cord-015021-pol2qm74 5373 4 was be VBD cord-015021-pol2qm74 5373 5 40~ 40~ CD cord-015021-pol2qm74 5373 6 at at IN cord-015021-pol2qm74 5373 7 48h 48h NNS cord-015021-pol2qm74 5373 8 after after IN cord-015021-pol2qm74 5373 9 AOC AOC NNP cord-015021-pol2qm74 5373 10 . . . cord-015021-pol2qm74 5374 1 At at IN cord-015021-pol2qm74 5374 2 6 6 CD cord-015021-pol2qm74 5374 3 , , , cord-015021-pol2qm74 5374 4 12 12 CD cord-015021-pol2qm74 5374 5 , , , cord-015021-pol2qm74 5374 6 24 24 CD cord-015021-pol2qm74 5374 7 , , , cord-015021-pol2qm74 5374 8 48h 48h NNS cord-015021-pol2qm74 5374 9 after after IN cord-015021-pol2qm74 5374 10 AOC AOC NNP cord-015021-pol2qm74 5374 11 , , , cord-015021-pol2qm74 5374 12 KCs kc NNS cord-015021-pol2qm74 5374 13 were be VBD cord-015021-pol2qm74 5374 14 isotated isotate VBN cord-015021-pol2qm74 5374 15 and and CC cord-015021-pol2qm74 5374 16 cultured culture VBN cord-015021-pol2qm74 5374 17 atone atone NN cord-015021-pol2qm74 5374 18 or or CC cord-015021-pol2qm74 5374 19 cocuttured cocutture VBN cord-015021-pol2qm74 5374 20 with with IN cord-015021-pol2qm74 5374 21 hepatocytes hepatocyte NNS cord-015021-pol2qm74 5374 22 to to TO cord-015021-pol2qm74 5374 23 evaluate evaluate VB cord-015021-pol2qm74 5374 24 the the DT cord-015021-pol2qm74 5374 25 modulation modulation NN cord-015021-pol2qm74 5374 26 effect effect NN cord-015021-pol2qm74 5374 27 of of IN cord-015021-pol2qm74 5374 28 Kgs Kgs NNP cord-015021-pol2qm74 5374 29 on on IN cord-015021-pol2qm74 5374 30 hepatoeyte hepatoeyte NNP cord-015021-pol2qm74 5374 31 protein protein NN cord-015021-pol2qm74 5374 32 synthesis synthesis NN cord-015021-pol2qm74 5374 33 . . . cord-015021-pol2qm74 5375 1 The the DT cord-015021-pol2qm74 5375 2 results result NNS cord-015021-pol2qm74 5375 3 showed show VBD cord-015021-pol2qm74 5375 4 that that IN cord-015021-pol2qm74 5375 5 tactodehydrogenase tactodehydrogenase IN cord-015021-pol2qm74 5375 6 leakage leakage NN cord-015021-pol2qm74 5375 7 was be VBD cord-015021-pol2qm74 5375 8 increased increase VBN cord-015021-pol2qm74 5375 9 progressively progressively RB cord-015021-pol2qm74 5375 10 as as IN cord-015021-pol2qm74 5375 11 the the DT cord-015021-pol2qm74 5375 12 injured injured JJ cord-015021-pol2qm74 5375 13 k~ k~ CD cord-015021-pol2qm74 5375 14 function function NN cord-015021-pol2qm74 5375 15 and and CC cord-015021-pol2qm74 5375 16 structure structure NN cord-015021-pol2qm74 5375 17 developed develop VBD cord-015021-pol2qm74 5375 18 . . . cord-015021-pol2qm74 5376 1 TNF TNF NNP cord-015021-pol2qm74 5376 2 and and CC cord-015021-pol2qm74 5376 3 IL IL NNP cord-015021-pol2qm74 5376 4 - - : cord-015021-pol2qm74 5376 5 I I NNP cord-015021-pol2qm74 5376 6 tn tn NNP cord-015021-pol2qm74 5377 1 the the DT cord-015021-pol2qm74 5377 2 supernatant supernatant NN cord-015021-pol2qm74 5377 3 were be VBD cord-015021-pol2qm74 5377 4 detected detect VBN cord-015021-pol2qm74 5377 5 with with IN cord-015021-pol2qm74 5377 6 the the DT cord-015021-pol2qm74 5377 7 peak peak NN cord-015021-pol2qm74 5377 8 values value NNS cord-015021-pol2qm74 5377 9 at at IN cord-015021-pol2qm74 5377 10 12h 12h CD cord-015021-pol2qm74 5377 11 after after IN cord-015021-pol2qm74 5377 12 AOC AOC NNP cord-015021-pol2qm74 5377 13 . . . cord-015021-pol2qm74 5378 1 At at IN cord-015021-pol2qm74 5378 2 48h 48h NNS cord-015021-pol2qm74 5378 3 after after IN cord-015021-pol2qm74 5378 4 AOC AOC NNP cord-015021-pol2qm74 5378 5 , , , cord-015021-pol2qm74 5378 6 ~-teueine ~-teueine NNP cord-015021-pol2qm74 5378 7 incorporation incorporation NN cord-015021-pol2qm74 5378 8 was be VBD cord-015021-pol2qm74 5378 9 obviousty obviousty NNP cord-015021-pol2qm74 5378 10 decreased decrease VBD cord-015021-pol2qm74 5378 11 in in IN cord-015021-pol2qm74 5378 12 the the DT cord-015021-pol2qm74 5378 13 normal normal JJ cord-015021-pol2qm74 5378 14 hepatocytes hepatocyte NNS cord-015021-pol2qm74 5378 15 eocuttured eocutture VBN cord-015021-pol2qm74 5378 16 with with IN cord-015021-pol2qm74 5378 17 stimulated stimulate VBN cord-015021-pol2qm74 5378 18 KCs kc NNS cord-015021-pol2qm74 5378 19 compared compare VBN cord-015021-pol2qm74 5378 20 to to IN cord-015021-pol2qm74 5378 21 the the DT cord-015021-pol2qm74 5378 22 uormai uormai NNP cord-015021-pol2qm74 5378 23 hepatocyte hepatocyte NN cord-015021-pol2qm74 5378 24 cultured cultured JJ cord-015021-pol2qm74 5378 25 group group NN cord-015021-pol2qm74 5378 26 ( ( -LRB- cord-015021-pol2qm74 5378 27 P<8.01 p<8.01 JJ cord-015021-pol2qm74 5378 28 ) ) -RRB- cord-015021-pol2qm74 5378 29 , , , cord-015021-pol2qm74 5378 30 but but CC cord-015021-pol2qm74 5378 31 it -PRON- PRP cord-015021-pol2qm74 5378 32 was be VBD cord-015021-pol2qm74 5378 33 slgnificantiy slgnificantiy NNP cord-015021-pol2qm74 5378 34 increased increase VBD cord-015021-pol2qm74 5378 35 in in IN cord-015021-pol2qm74 5378 36 the the DT cord-015021-pol2qm74 5378 37 group group NN cord-015021-pol2qm74 5378 38 cocuLtured coculture VBN cord-015021-pol2qm74 5378 39 with with IN cord-015021-pol2qm74 5378 40 normal normal JJ cord-015021-pol2qm74 5378 41 KCs kc NNS cord-015021-pol2qm74 5378 42 . . . cord-015021-pol2qm74 5379 1 In in IN cord-015021-pol2qm74 5379 2 the the DT cord-015021-pol2qm74 5379 3 A0C A0C NNP cord-015021-pol2qm74 5379 4 group group NN cord-015021-pol2qm74 5379 5 , , , cord-015021-pol2qm74 5379 6 ' ' '' cord-015021-pol2qm74 5379 7 H H NNP cord-015021-pol2qm74 5379 8 - - HYPH cord-015021-pol2qm74 5379 9 teuclne teuclne NNP cord-015021-pol2qm74 5379 10 ineorporatien ineorporatien NNP cord-015021-pol2qm74 5379 11 was be VBD cord-015021-pol2qm74 5379 12 decreased decrease VBN cord-015021-pol2qm74 5379 13 progressively progressively RB cord-015021-pol2qm74 5379 14 in in IN cord-015021-pol2qm74 5379 15 the the DT cord-015021-pol2qm74 5379 16 injured injure VBN cord-015021-pol2qm74 5379 17 hepatoeytes hepatoeyte NNS cord-015021-pol2qm74 5379 18 cocuttured cocutture VBD cord-015021-pol2qm74 5379 19 with with IN cord-015021-pol2qm74 5379 20 stimuLatedKgs stimuLatedKgs NNP cord-015021-pol2qm74 5380 1 and and CC cord-015021-pol2qm74 5380 2 it -PRON- PRP cord-015021-pol2qm74 5380 3 was be VBD cord-015021-pol2qm74 5380 4 markedly markedly RB cord-015021-pol2qm74 5380 5 elevated elevate VBN cord-015021-pol2qm74 5380 6 when when WRB cord-015021-pol2qm74 5380 7 cocuttured cocuttured JJ cord-015021-pol2qm74 5380 8 wlthnormat wlthnormat NNP cord-015021-pol2qm74 5380 9 KCs KCs NNPS cord-015021-pol2qm74 5380 10 at at IN cord-015021-pol2qm74 5380 11 48h 48h NNS cord-015021-pol2qm74 5380 12 after after IN cord-015021-pol2qm74 5380 13 A0C A0C NNP cord-015021-pol2qm74 5380 14 ( ( -LRB- cord-015021-pol2qm74 5380 15 P<0 P<0 NNP cord-015021-pol2qm74 5380 16 . . . cord-015021-pol2qm74 5381 1 Og Og NNP cord-015021-pol2qm74 5381 2 ) ) -RRB- cord-015021-pol2qm74 5381 3 . . . cord-015021-pol2qm74 5382 1 It -PRON- PRP cord-015021-pol2qm74 5382 2 is be VBZ cord-015021-pol2qm74 5382 3 concluded conclude VBN cord-015021-pol2qm74 5382 4 that that IN cord-015021-pol2qm74 5382 5 the the DT cord-015021-pol2qm74 5382 6 impaired impair VBN cord-015021-pol2qm74 5382 7 hepatocyte hepatocyte NN cord-015021-pol2qm74 5382 8 proterin proterin NN cord-015021-pol2qm74 5382 9 synthesis synthesis NN cord-015021-pol2qm74 5382 10 was be VBD cord-015021-pol2qm74 5382 11 directly directly RB cord-015021-pol2qm74 5382 12 mediated mediate VBN cord-015021-pol2qm74 5382 13 hy hy NNP cord-015021-pol2qm74 5382 14 the the DT cord-015021-pol2qm74 5382 15 stimulated stimulate VBN cord-015021-pol2qm74 5382 16 KC KC NNP cord-015021-pol2qm74 5382 17 function function NN cord-015021-pol2qm74 5382 18 during during IN cord-015021-pol2qm74 5382 19 AOC AOC NNP cord-015021-pol2qm74 5382 20 . . . cord-015021-pol2qm74 5383 1 Such such JJ cord-015021-pol2qm74 5383 2 a a DT cord-015021-pol2qm74 5383 3 mechanism mechanism NN cord-015021-pol2qm74 5383 4 possibly possibly RB cord-015021-pol2qm74 5383 5 may may MD cord-015021-pol2qm74 5383 6 be be VB cord-015021-pol2qm74 5383 7 involved involve VBN cord-015021-pol2qm74 5383 8 in in IN cord-015021-pol2qm74 5383 9 the the DT cord-015021-pol2qm74 5383 10 patho0ensis patho0ensi NNS cord-015021-pol2qm74 5383 11 of of IN cord-015021-pol2qm74 5383 12 hepatic hepatic JJ cord-015021-pol2qm74 5383 13 dysfunction dysfunction NN cord-015021-pol2qm74 5383 14 and and CC cord-015021-pol2qm74 5383 15 M0F m0f NN cord-015021-pol2qm74 5383 16 following follow VBG cord-015021-pol2qm74 5383 17 h06 h06 CD cord-015021-pol2qm74 5383 18 . . . cord-015021-pol2qm74 5384 1 " " '' cord-015021-pol2qm74 5385 1 The the DT cord-015021-pol2qm74 5385 2 project project NN cord-015021-pol2qm74 5385 3 supported support VBN cord-015021-pol2qm74 5385 4 by by IN cord-015021-pol2qm74 5385 5 NSFC NSFC NNP cord-015021-pol2qm74 5385 6 . . . cord-015021-pol2qm74 5386 1 In in IN cord-015021-pol2qm74 5386 2 the the DT cord-015021-pol2qm74 5386 3 past past JJ cord-015021-pol2qm74 5386 4 few few JJ cord-015021-pol2qm74 5386 5 years year NNS cord-015021-pol2qm74 5386 6 it -PRON- PRP cord-015021-pol2qm74 5386 7 has have VBZ cord-015021-pol2qm74 5386 8 become become VBN cord-015021-pol2qm74 5386 9 evident evident JJ cord-015021-pol2qm74 5386 10 that that IN cord-015021-pol2qm74 5386 11 cytokines cytokine NNS cord-015021-pol2qm74 5386 12 are be VBP cord-015021-pol2qm74 5386 13 implicated implicate VBN cord-015021-pol2qm74 5386 14 in in IN cord-015021-pol2qm74 5386 15 various various JJ cord-015021-pol2qm74 5386 16 pathophysiological pathophysiological JJ cord-015021-pol2qm74 5386 17 mechanisms mechanism NNS cord-015021-pol2qm74 5386 18 . . . cord-015021-pol2qm74 5387 1 Therefore therefore RB cord-015021-pol2qm74 5387 2 measurement measurement NN cord-015021-pol2qm74 5387 3 of of IN cord-015021-pol2qm74 5387 4 cytokines cytokine NNS cord-015021-pol2qm74 5387 5 and and CC cord-015021-pol2qm74 5387 6 their -PRON- PRP$ cord-015021-pol2qm74 5387 7 potential potential JJ cord-015021-pol2qm74 5387 8 inhibitors inhibitor NNS cord-015021-pol2qm74 5387 9 in in IN cord-015021-pol2qm74 5387 10 biological biological JJ cord-015021-pol2qm74 5387 11 fluids fluid NNS cord-015021-pol2qm74 5387 12 may may MD cord-015021-pol2qm74 5387 13 be be VB cord-015021-pol2qm74 5387 14 helpful helpful JJ cord-015021-pol2qm74 5387 15 in in IN cord-015021-pol2qm74 5387 16 diagnosing diagnose VBG cord-015021-pol2qm74 5387 17 and and CC cord-015021-pol2qm74 5387 18 monitoring monitoring NN cord-015021-pol2qm74 5387 19 of of IN cord-015021-pol2qm74 5387 20 diseases disease NNS cord-015021-pol2qm74 5387 21 . . . cord-015021-pol2qm74 5388 1 However however RB cord-015021-pol2qm74 5388 2 , , , cord-015021-pol2qm74 5388 3 dependent dependent JJ cord-015021-pol2qm74 5388 4 on on IN cord-015021-pol2qm74 5388 5 the the DT cord-015021-pol2qm74 5388 6 type type NN cord-015021-pol2qm74 5388 7 of of IN cord-015021-pol2qm74 5388 8 assay assay NN cord-015021-pol2qm74 5388 9 used use VBN cord-015021-pol2qm74 5388 10 investigations investigation NNS cord-015021-pol2qm74 5388 11 performed perform VBN cord-015021-pol2qm74 5388 12 in in IN cord-015021-pol2qm74 5388 13 different different JJ cord-015021-pol2qm74 5388 14 laboratories laboratory NNS cord-015021-pol2qm74 5388 15 have have VBP cord-015021-pol2qm74 5388 16 often often RB cord-015021-pol2qm74 5388 17 yielded yield VBN cord-015021-pol2qm74 5388 18 conflicting conflicting JJ cord-015021-pol2qm74 5388 19 results result NNS cord-015021-pol2qm74 5388 20 . . . cord-015021-pol2qm74 5389 1 In in IN cord-015021-pol2qm74 5389 2 order order NN cord-015021-pol2qm74 5389 3 to to TO cord-015021-pol2qm74 5389 4 assess assess VB cord-015021-pol2qm74 5389 5 reliability reliability NN cord-015021-pol2qm74 5389 6 and and CC cord-015021-pol2qm74 5389 7 reproducibility reproducibility NN cord-015021-pol2qm74 5389 8 of of IN cord-015021-pol2qm74 5389 9 cytokine cytokine NN cord-015021-pol2qm74 5389 10 measurements measurement NNS cord-015021-pol2qm74 5389 11 two two CD cord-015021-pol2qm74 5389 12 comparative comparative JJ cord-015021-pol2qm74 5389 13 studies study NNS cord-015021-pol2qm74 5389 14 for for IN cord-015021-pol2qm74 5389 15 the the DT cord-015021-pol2qm74 5389 16 determination determination NN cord-015021-pol2qm74 5389 17 of of IN cord-015021-pol2qm74 5389 18 cytokines cytokine NNS cord-015021-pol2qm74 5389 19 in in IN cord-015021-pol2qm74 5389 20 biological biological JJ cord-015021-pol2qm74 5389 21 fluids fluid NNS cord-015021-pol2qm74 5389 22 were be VBD cord-015021-pol2qm74 5389 23 launched launch VBN cord-015021-pol2qm74 5389 24 by by IN cord-015021-pol2qm74 5389 25 several several JJ cord-015021-pol2qm74 5389 26 investigators investigator NNS cord-015021-pol2qm74 5389 27 interested interested JJ cord-015021-pol2qm74 5389 28 in in IN cord-015021-pol2qm74 5389 29 this this DT cord-015021-pol2qm74 5389 30 field field NN cord-015021-pol2qm74 5389 31 : : : cord-015021-pol2qm74 5390 1 one one CD cord-015021-pol2qm74 5390 2 national national JJ cord-015021-pol2qm74 5390 3 Austrian Austrian NNP cord-015021-pol2qm74 5390 4 ~tudy ~tudy NNP cord-015021-pol2qm74 5390 5 and and CC cord-015021-pol2qm74 5390 6 one one CD cord-015021-pol2qm74 5390 7 European european JJ cord-015021-pol2qm74 5390 8 study study NN cord-015021-pol2qm74 5390 9 in in IN cord-015021-pol2qm74 5390 10 the the DT cord-015021-pol2qm74 5390 11 context context NN cord-015021-pol2qm74 5390 12 of of IN cord-015021-pol2qm74 5390 13 the the DT cord-015021-pol2qm74 5390 14 European European NNP cord-015021-pol2qm74 5390 15 Workshop Workshop NNP cord-015021-pol2qm74 5390 16 for for IN cord-015021-pol2qm74 5390 17 Rheumatnlogy Rheumatnlogy NNP cord-015021-pol2qm74 5390 18 Research Research NNP cord-015021-pol2qm74 5390 19 . . . cord-015021-pol2qm74 5391 1 Serum serum NN cord-015021-pol2qm74 5391 2 and and CC cord-015021-pol2qm74 5391 3 synovial synovial JJ cord-015021-pol2qm74 5391 4 fluid fluid JJ cord-015021-pol2qm74 5391 5 samples sample NNS cord-015021-pol2qm74 5391 6 were be VBD cord-015021-pol2qm74 5391 7 distributed distribute VBN cord-015021-pol2qm74 5391 8 by by IN cord-015021-pol2qm74 5391 9 the the DT cord-015021-pol2qm74 5391 10 organisers organiser NNS cord-015021-pol2qm74 5391 11 , , , cord-015021-pol2qm74 5391 12 and and CC cord-015021-pol2qm74 5391 13 participants participant NNS cord-015021-pol2qm74 5391 14 had have VBD cord-015021-pol2qm74 5391 15 to to TO cord-015021-pol2qm74 5391 16 measure measure VB cord-015021-pol2qm74 5391 17 one one CD cord-015021-pol2qm74 5391 18 or or CC cord-015021-pol2qm74 5391 19 several several JJ cord-015021-pol2qm74 5391 20 of of IN cord-015021-pol2qm74 5391 21 the the DT cord-015021-pol2qm74 5391 22 following follow VBG cord-015021-pol2qm74 5391 23 cytokines cytokine NNS cord-015021-pol2qm74 5391 24 in in IN cord-015021-pol2qm74 5391 25 all all DT cord-015021-pol2qm74 5391 26 samples sample NNS cord-015021-pol2qm74 5391 27 : : : cord-015021-pol2qm74 5392 1 IL-1 IL-1 NNP cord-015021-pol2qm74 5392 2 , , , cord-015021-pol2qm74 5392 3 IL-2 IL-2 NNP cord-015021-pol2qm74 5392 4 , , , cord-015021-pol2qm74 5392 5 1L-6 1l-6 CD cord-015021-pol2qm74 5392 6 , , , cord-015021-pol2qm74 5393 1 I58 I58 NNP cord-015021-pol2qm74 5393 2 , , , cord-015021-pol2qm74 5393 3 TNF tnf NN cord-015021-pol2qm74 5393 4 - - HYPH cord-015021-pol2qm74 5393 5 alpha alpha NN cord-015021-pol2qm74 5393 6 , , , cord-015021-pol2qm74 5393 7 IFN IFN NNP cord-015021-pol2qm74 5393 8 - - HYPH cord-015021-pol2qm74 5393 9 gamma gamma NN cord-015021-pol2qm74 5393 10 , , , cord-015021-pol2qm74 5393 11 GM GM NNP cord-015021-pol2qm74 5393 12 - - HYPH cord-015021-pol2qm74 5393 13 CSF CSF NNP cord-015021-pol2qm74 5393 14 , , , cord-015021-pol2qm74 5393 15 and and CC cord-015021-pol2qm74 5393 16 the the DT cord-015021-pol2qm74 5393 17 soluble soluble JJ cord-015021-pol2qm74 5393 18 receptors receptor NNS cord-015021-pol2qm74 5393 19 for for IN cord-015021-pol2qm74 5393 20 IL-2 IL-2 NNP cord-015021-pol2qm74 5393 21 and and CC cord-015021-pol2qm74 5393 22 TNF TNF NNP cord-015021-pol2qm74 5393 23 ; ; : cord-015021-pol2qm74 5393 24 both both DT cord-015021-pol2qm74 5393 25 commercially commercially RB cord-015021-pol2qm74 5393 26 available available JJ cord-015021-pol2qm74 5393 27 immunoassays immunoassay NNS cord-015021-pol2qm74 5393 28 and and CC cord-015021-pol2qm74 5393 29 home home NN cord-015021-pol2qm74 5393 30 - - HYPH cord-015021-pol2qm74 5393 31 made make VBN cord-015021-pol2qm74 5393 32 assays assay NNS cord-015021-pol2qm74 5393 33 were be VBD cord-015021-pol2qm74 5393 34 allowed allow VBN cord-015021-pol2qm74 5393 35 . . . cord-015021-pol2qm74 5394 1 So so RB cord-015021-pol2qm74 5394 2 far far RB cord-015021-pol2qm74 5394 3 , , , cord-015021-pol2qm74 5394 4 the the DT cord-015021-pol2qm74 5394 5 main main JJ cord-015021-pol2qm74 5394 6 conclusions conclusion NNS cord-015021-pol2qm74 5394 7 emerging emerge VBG cord-015021-pol2qm74 5394 8 from from IN cord-015021-pol2qm74 5394 9 these these DT cord-015021-pol2qm74 5394 10 preliminary preliminary JJ cord-015021-pol2qm74 5394 11 studies study NNS cord-015021-pol2qm74 5394 12 are be VBP cord-015021-pol2qm74 5394 13 : : : cord-015021-pol2qm74 5394 14 ( ( -LRB- cord-015021-pol2qm74 5394 15 1 1 LS cord-015021-pol2qm74 5394 16 ) ) -RRB- cord-015021-pol2qm74 5394 17 the the DT cord-015021-pol2qm74 5394 18 same same JJ cord-015021-pol2qm74 5394 19 immurzoassay immurzoassay NNP cord-015021-pol2qm74 5394 20 ( ( -LRB- cord-015021-pol2qm74 5394 21 ELISA ELISA NNP cord-015021-pol2qm74 5394 22 ) ) -RRB- cord-015021-pol2qm74 5394 23 yielded yield VBD cord-015021-pol2qm74 5394 24 comparable comparable JJ cord-015021-pol2qm74 5394 25 results result NNS cord-015021-pol2qm74 5394 26 in in IN cord-015021-pol2qm74 5394 27 different different JJ cord-015021-pol2qm74 5394 28 laboratories laboratory NNS cord-015021-pol2qm74 5395 1 ; ; : cord-015021-pol2qm74 5395 2 ( ( -LRB- cord-015021-pol2qm74 5395 3 2 2 LS cord-015021-pol2qm74 5395 4 ) ) -RRB- cord-015021-pol2qm74 5395 5 immunoassays immunoassay NNS cord-015021-pol2qm74 5395 6 from from IN cord-015021-pol2qm74 5395 7 different different JJ cord-015021-pol2qm74 5395 8 manufactureres manufacturere NNS cord-015021-pol2qm74 5395 9 usually usually RB cord-015021-pol2qm74 5395 10 measured measure VBD cord-015021-pol2qm74 5395 11 the the DT cord-015021-pol2qm74 5395 12 highest high JJS cord-015021-pol2qm74 5395 13 concentrations concentration NNS cord-015021-pol2qm74 5395 14 in in IN cord-015021-pol2qm74 5395 15 the the DT cord-015021-pol2qm74 5395 16 same same JJ cord-015021-pol2qm74 5395 17 samples sample NNS cord-015021-pol2qm74 5395 18 , , , cord-015021-pol2qm74 5395 19 yielded yield VBD cord-015021-pol2qm74 5395 20 similar similar JJ cord-015021-pol2qm74 5395 21 relative relative JJ cord-015021-pol2qm74 5395 22 values value NNS cord-015021-pol2qm74 5395 23 but but CC cord-015021-pol2qm74 5395 24 disparate disparate JJ cord-015021-pol2qm74 5395 25 absolute absolute JJ cord-015021-pol2qm74 5395 26 values value NNS cord-015021-pol2qm74 5395 27 ; ; , cord-015021-pol2qm74 5395 28 ( ( -LRB- cord-015021-pol2qm74 5395 29 3 3 LS cord-015021-pol2qm74 5395 30 ) ) -RRB- cord-015021-pol2qm74 5395 31 assays assay NNS cord-015021-pol2qm74 5395 32 for for IN cord-015021-pol2qm74 5395 33 soluble soluble JJ cord-015021-pol2qm74 5395 34 receptors receptor NNS cord-015021-pol2qm74 5395 35 yielded yield VBD cord-015021-pol2qm74 5395 36 less less RBR cord-015021-pol2qm74 5395 37 discrepant discrepant JJ cord-015021-pol2qm74 5395 38 results result NNS cord-015021-pol2qm74 5395 39 ; ; , cord-015021-pol2qm74 5395 40 ( ( -LRB- cord-015021-pol2qm74 5395 41 4 4 LS cord-015021-pol2qm74 5395 42 ) ) -RRB- cord-015021-pol2qm74 5395 43 some some DT cord-015021-pol2qm74 5395 44 assays assay NNS cord-015021-pol2qm74 5395 45 seem seem VBP cord-015021-pol2qm74 5395 46 to to TO cord-015021-pol2qm74 5395 47 be be VB cord-015021-pol2qm74 5395 48 more more RBR cord-015021-pol2qm74 5395 49 suitable suitable JJ cord-015021-pol2qm74 5395 50 for for IN cord-015021-pol2qm74 5395 51 measuring measure VBG cord-015021-pol2qm74 5395 52 cytokines cytokine NNS cord-015021-pol2qm74 5395 53 in in IN cord-015021-pol2qm74 5395 54 biological biological JJ cord-015021-pol2qm74 5395 55 fluids fluid NNS cord-015021-pol2qm74 5395 56 than than IN cord-015021-pol2qm74 5395 57 others other NNS cord-015021-pol2qm74 5395 58 . . . cord-015021-pol2qm74 5396 1 The the DT cord-015021-pol2qm74 5396 2 mean mean JJ cord-015021-pol2qm74 5396 3 retrieval retrieval NN cord-015021-pol2qm74 5396 4 of of IN cord-015021-pol2qm74 5396 5 exogenous exogenous JJ cord-015021-pol2qm74 5396 6 recombinant recombinant JJ cord-015021-pol2qm74 5396 7 human human JJ cord-015021-pol2qm74 5396 8 cytokines cytokine NNS cord-015021-pol2qm74 5396 9 was be VBD cord-015021-pol2qm74 5396 10 approximately approximately RB cord-015021-pol2qm74 5396 11 50 50 CD cord-015021-pol2qm74 5396 12 % % NN cord-015021-pol2qm74 5396 13 for for IN cord-015021-pol2qm74 5396 14 most most JJS cord-015021-pol2qm74 5396 15 cytokines cytokine NNS cord-015021-pol2qm74 5396 16 tested test VBN cord-015021-pol2qm74 5396 17 . . . cord-015021-pol2qm74 5397 1 However however RB cord-015021-pol2qm74 5397 2 , , , cord-015021-pol2qm74 5397 3 it -PRON- PRP cord-015021-pol2qm74 5397 4 must must MD cord-015021-pol2qm74 5397 5 be be VB cord-015021-pol2qm74 5397 6 borne bear VBN cord-015021-pol2qm74 5397 7 in in IN cord-015021-pol2qm74 5397 8 mind mind NN cord-015021-pol2qm74 5397 9 that that IN cord-015021-pol2qm74 5397 10 natural natural JJ cord-015021-pol2qm74 5397 11 and and CC cord-015021-pol2qm74 5397 12 recombinant recombinant JJ cord-015021-pol2qm74 5397 13 cytokines cytokine NNS cord-015021-pol2qm74 5397 14 may may MD cord-015021-pol2qm74 5397 15 behave behave VB cord-015021-pol2qm74 5397 16 differently differently RB cord-015021-pol2qm74 5397 17 in in IN cord-015021-pol2qm74 5397 18 immunoassays immunoassays NNP cord-015021-pol2qm74 5397 19 . . . cord-015021-pol2qm74 5398 1 This this DT cord-015021-pol2qm74 5398 2 raises raise VBZ cord-015021-pol2qm74 5398 3 the the DT cord-015021-pol2qm74 5398 4 question question NN cord-015021-pol2qm74 5398 5 as as IN cord-015021-pol2qm74 5398 6 to to IN cord-015021-pol2qm74 5398 7 the the DT cord-015021-pol2qm74 5398 8 necessity necessity NN cord-015021-pol2qm74 5398 9 of of IN cord-015021-pol2qm74 5398 10 setting set VBG cord-015021-pol2qm74 5398 11 up up RP cord-015021-pol2qm74 5398 12 international international JJ cord-015021-pol2qm74 5398 13 standards standard NNS cord-015021-pol2qm74 5398 14 for for IN cord-015021-pol2qm74 5398 15 all all DT cord-015021-pol2qm74 5398 16 cytokines cytokine NNS cord-015021-pol2qm74 5398 17 . . . cord-015021-pol2qm74 5399 1 Possible possible JJ cord-015021-pol2qm74 5399 2 interferences interference NNS cord-015021-pol2qm74 5399 3 by by IN cord-015021-pol2qm74 5399 4 serum serum NN cord-015021-pol2qm74 5399 5 components component NNS cord-015021-pol2qm74 5399 6 such such JJ cord-015021-pol2qm74 5399 7 as as IN cord-015021-pol2qm74 5399 8 ( ( -LRB- cord-015021-pol2qm74 5399 9 lipo)proteins lipo)proteins NNP cord-015021-pol2qm74 5399 10 , , , cord-015021-pol2qm74 5399 11 complement complement NN cord-015021-pol2qm74 5399 12 , , , cord-015021-pol2qm74 5399 13 rheumatoid rheumatoid NN cord-015021-pol2qm74 5399 14 factors factor NNS cord-015021-pol2qm74 5399 15 , , , cord-015021-pol2qm74 5399 16 etc etc FW cord-015021-pol2qm74 5399 17 . . FW cord-015021-pol2qm74 5399 18 , , , cord-015021-pol2qm74 5399 19 which which WDT cord-015021-pol2qm74 5399 20 may may MD cord-015021-pol2qm74 5399 21 either either CC cord-015021-pol2qm74 5399 22 decrease decrease VB cord-015021-pol2qm74 5399 23 assay assay NN cord-015021-pol2qm74 5399 24 sensitivity sensitivity NN cord-015021-pol2qm74 5399 25 or or CC cord-015021-pol2qm74 5399 26 yield yield VB cord-015021-pol2qm74 5399 27 false false JJ cord-015021-pol2qm74 5399 28 positive positive JJ cord-015021-pol2qm74 5399 29 results result NNS cord-015021-pol2qm74 5399 30 , , , cord-015021-pol2qm74 5399 31 must must MD cord-015021-pol2qm74 5399 32 also also RB cord-015021-pol2qm74 5399 33 be be VB cord-015021-pol2qm74 5399 34 considered consider VBN cord-015021-pol2qm74 5399 35 . . . cord-015021-pol2qm74 5400 1 In in IN cord-015021-pol2qm74 5400 2 addition addition NN cord-015021-pol2qm74 5400 3 , , , cord-015021-pol2qm74 5400 4 natural natural JJ cord-015021-pol2qm74 5400 5 cytokine cytokine NN cord-015021-pol2qm74 5400 6 binding bind VBG cord-015021-pol2qm74 5400 7 proteins protein NNS cord-015021-pol2qm74 5400 8 ( ( -LRB- cord-015021-pol2qm74 5400 9 e.g. e.g. IN cord-015021-pol2qm74 5400 10 soluble soluble JJ cord-015021-pol2qm74 5400 11 receptors receptor NNS cord-015021-pol2qm74 5400 12 ) ) -RRB- cord-015021-pol2qm74 5400 13 might may MD cord-015021-pol2qm74 5400 14 interfere interfere VB cord-015021-pol2qm74 5400 15 with with IN cord-015021-pol2qm74 5400 16 cytokine cytokine JJ cord-015021-pol2qm74 5400 17 determination determination NN cord-015021-pol2qm74 5400 18 in in IN cord-015021-pol2qm74 5400 19 immunoassays immunoassays NNP cord-015021-pol2qm74 5400 20 . . . cord-015021-pol2qm74 5401 1 The the DT cord-015021-pol2qm74 5401 2 problem problem NN cord-015021-pol2qm74 5401 3 of of IN cord-015021-pol2qm74 5401 4 immunoassays immunoassays NNP cord-015021-pol2qm74 5401 5 versus versus IN cord-015021-pol2qm74 5401 6 bioassays bioassays NNP cord-015021-pol2qm74 5401 7 has have VBZ cord-015021-pol2qm74 5401 8 not not RB cord-015021-pol2qm74 5401 9 yet yet RB cord-015021-pol2qm74 5401 10 been be VBN cord-015021-pol2qm74 5401 11 approached approach VBN cord-015021-pol2qm74 5401 12 , , , cord-015021-pol2qm74 5401 13 but but CC cord-015021-pol2qm74 5401 14 is be VBZ cord-015021-pol2qm74 5401 15 without without IN cord-015021-pol2qm74 5401 16 any any DT cord-015021-pol2qm74 5401 17 doubt doubt NN cord-015021-pol2qm74 5401 18 worth worth JJ cord-015021-pol2qm74 5401 19 indepth indepth JJ cord-015021-pol2qm74 5401 20 investigation investigation NN cord-015021-pol2qm74 5401 21 . . . cord-015021-pol2qm74 5402 1 Thus thus RB cord-015021-pol2qm74 5402 2 , , , cord-015021-pol2qm74 5402 3 these these DT cord-015021-pol2qm74 5402 4 studies study NNS cord-015021-pol2qm74 5402 5 are be VBP cord-015021-pol2qm74 5402 6 a a DT cord-015021-pol2qm74 5402 7 promising promising JJ cord-015021-pol2qm74 5402 8 first first JJ cord-015021-pol2qm74 5402 9 approach approach NN cord-015021-pol2qm74 5402 10 to to TO cord-015021-pol2qm74 5402 11 deal deal VB cord-015021-pol2qm74 5402 12 with with IN cord-015021-pol2qm74 5402 13 the the DT cord-015021-pol2qm74 5402 14 difficulties difficulty NNS cord-015021-pol2qm74 5402 15 of of IN cord-015021-pol2qm74 5402 16 cytokine cytokine NN cord-015021-pol2qm74 5402 17 analysis analysis NN cord-015021-pol2qm74 5402 18 in in IN cord-015021-pol2qm74 5402 19 biological biological JJ cord-015021-pol2qm74 5402 20 samples sample NNS cord-015021-pol2qm74 5402 21 , , , cord-015021-pol2qm74 5402 22 and and CC cord-015021-pol2qm74 5402 23 it -PRON- PRP cord-015021-pol2qm74 5402 24 is be VBZ cord-015021-pol2qm74 5402 25 hoped hope VBN cord-015021-pol2qm74 5402 26 that that IN cord-015021-pol2qm74 5402 27 they -PRON- PRP cord-015021-pol2qm74 5402 28 will will MD cord-015021-pol2qm74 5402 29 help help VB cord-015021-pol2qm74 5402 30 to to TO cord-015021-pol2qm74 5402 31 overcome overcome VB cord-015021-pol2qm74 5402 32 some some DT cord-015021-pol2qm74 5402 33 of of IN cord-015021-pol2qm74 5402 34 the the DT cord-015021-pol2qm74 5402 35 major major JJ cord-015021-pol2qm74 5402 36 methodological methodological JJ cord-015021-pol2qm74 5402 37 problems problem NNS cord-015021-pol2qm74 5402 38 in in IN cord-015021-pol2qm74 5402 39 the the DT cord-015021-pol2qm74 5402 40 near near JJ cord-015021-pol2qm74 5402 41 future future NN cord-015021-pol2qm74 5402 42 . . . cord-015021-pol2qm74 5403 1 Tumor tumor NN cord-015021-pol2qm74 5403 2 necrosis necrosis NN cord-015021-pol2qm74 5403 3 factor factor NN cord-015021-pol2qm74 5403 4 ( ( -LRB- cord-015021-pol2qm74 5403 5 TNF TNF NNP cord-015021-pol2qm74 5403 6 ) ) -RRB- cord-015021-pol2qm74 5403 7 is be VBZ cord-015021-pol2qm74 5403 8 a a DT cord-015021-pol2qm74 5403 9 pleiotropic pleiotropic JJ cord-015021-pol2qm74 5403 10 cytokine cytokine NN cord-015021-pol2qm74 5403 11 which which WDT cord-015021-pol2qm74 5403 12 plays play VBZ cord-015021-pol2qm74 5403 13 a a DT cord-015021-pol2qm74 5403 14 key key JJ cord-015021-pol2qm74 5403 15 role role NN cord-015021-pol2qm74 5403 16 in in IN cord-015021-pol2qm74 5403 17 a a DT cord-015021-pol2qm74 5403 18 number number NN cord-015021-pol2qm74 5403 19 of of IN cord-015021-pol2qm74 5403 20 immunologically immunologically RB cord-015021-pol2qm74 5403 21 mediated mediate VBN cord-015021-pol2qm74 5403 22 disorders disorder NNS cord-015021-pol2qm74 5403 23 like like IN cord-015021-pol2qm74 5403 24 septicemia septicemia NN cord-015021-pol2qm74 5403 25 or or CC cord-015021-pol2qm74 5403 26 cachexia cachexia NN cord-015021-pol2qm74 5403 27 . . . cord-015021-pol2qm74 5404 1 TNF TNF NNP cord-015021-pol2qm74 5404 2 receptors receptor NNS cord-015021-pol2qm74 5404 3 are be VBP cord-015021-pol2qm74 5404 4 found find VBN cord-015021-pol2qm74 5404 5 on on IN cord-015021-pol2qm74 5404 6 the the DT cord-015021-pol2qm74 5404 7 surface surface NN cord-015021-pol2qm74 5404 8 of of IN cord-015021-pol2qm74 5404 9 a a DT cord-015021-pol2qm74 5404 10 variety variety NN cord-015021-pol2qm74 5404 11 of of IN cord-015021-pol2qm74 5404 12 cells cell NNS cord-015021-pol2qm74 5404 13 , , , cord-015021-pol2qm74 5404 14 where where WRB cord-015021-pol2qm74 5404 15 they -PRON- PRP cord-015021-pol2qm74 5404 16 provide provide VBP cord-015021-pol2qm74 5404 17 molecular molecular JJ cord-015021-pol2qm74 5404 18 signals signal NNS cord-015021-pol2qm74 5404 19 for for IN cord-015021-pol2qm74 5404 20 the the DT cord-015021-pol2qm74 5404 21 cytokine cytokine NN cord-015021-pol2qm74 5404 22 effect effect NN cord-015021-pol2qm74 5404 23 . . . cord-015021-pol2qm74 5405 1 There there EX cord-015021-pol2qm74 5405 2 exist exist VBP cord-015021-pol2qm74 5405 3 two two CD cord-015021-pol2qm74 5405 4 types type NNS cord-015021-pol2qm74 5405 5 of of IN cord-015021-pol2qm74 5405 6 soluble soluble JJ cord-015021-pol2qm74 5405 7 TNF TNF NNP cord-015021-pol2qm74 5405 8 receptors receptor NNS cord-015021-pol2qm74 5405 9 ( ( -LRB- cord-015021-pol2qm74 5405 10 sTNF stnf NN cord-015021-pol2qm74 5405 11 - - HYPH cord-015021-pol2qm74 5405 12 Rs r NNS cord-015021-pol2qm74 5405 13 ) ) -RRB- cord-015021-pol2qm74 5405 14 , , , cord-015021-pol2qm74 5405 15 TNF TNF NNP cord-015021-pol2qm74 5405 16 - - HYPH cord-015021-pol2qm74 5405 17 R R NNP cord-015021-pol2qm74 5405 18 p55 p55 NN cord-015021-pol2qm74 5405 19 and and CC cord-015021-pol2qm74 5405 20 TNF TNF NNP cord-015021-pol2qm74 5405 21 - - HYPH cord-015021-pol2qm74 5405 22 R R NNP cord-015021-pol2qm74 5405 23 p75 p75 NN cord-015021-pol2qm74 5405 24 . . . cord-015021-pol2qm74 5406 1 These these DT cord-015021-pol2qm74 5406 2 sTNF stnf NN cord-015021-pol2qm74 5406 3 - - HYPH cord-015021-pol2qm74 5406 4 Rs r NNS cord-015021-pol2qm74 5406 5 can can MD cord-015021-pol2qm74 5406 6 compete compete VB cord-015021-pol2qm74 5406 7 with with IN cord-015021-pol2qm74 5406 8 the the DT cord-015021-pol2qm74 5406 9 cell cell NN cord-015021-pol2qm74 5406 10 surface surface NN cord-015021-pol2qm74 5406 11 receptors receptor NNS cord-015021-pol2qm74 5406 12 and and CC cord-015021-pol2qm74 5406 13 block block VB cord-015021-pol2qm74 5406 14 their -PRON- PRP$ cord-015021-pol2qm74 5406 15 activity activity NN cord-015021-pol2qm74 5406 16 . . . cord-015021-pol2qm74 5407 1 The the DT cord-015021-pol2qm74 5407 2 expression expression NN cord-015021-pol2qm74 5407 3 on on IN cord-015021-pol2qm74 5407 4 and and CC cord-015021-pol2qm74 5407 5 shedding shed VBG cord-015021-pol2qm74 5407 6 from from IN cord-015021-pol2qm74 5407 7 the the DT cord-015021-pol2qm74 5407 8 cell cell NN cord-015021-pol2qm74 5407 9 surface surface NN cord-015021-pol2qm74 5407 10 of of IN cord-015021-pol2qm74 5407 11 sTNF stnf NN cord-015021-pol2qm74 5407 12 - - HYPH cord-015021-pol2qm74 5407 13 Rs rs NN cord-015021-pol2qm74 5407 14 is be VBZ cord-015021-pol2qm74 5407 15 enhanced enhance VBN cord-015021-pol2qm74 5407 16 by by IN cord-015021-pol2qm74 5407 17 interferon interferon NN cord-015021-pol2qm74 5407 18 gamma gamma NN cord-015021-pol2qm74 5407 19 . . . cord-015021-pol2qm74 5408 1 Increased increase VBN cord-015021-pol2qm74 5408 2 concentrations concentration NNS cord-015021-pol2qm74 5408 3 of of IN cord-015021-pol2qm74 5408 4 sTNF stnf NN cord-015021-pol2qm74 5408 5 - - HYPH cord-015021-pol2qm74 5408 6 Rs r NNS cord-015021-pol2qm74 5408 7 can can MD cord-015021-pol2qm74 5408 8 be be VB cord-015021-pol2qm74 5408 9 found find VBN cord-015021-pol2qm74 5408 10 in in IN cord-015021-pol2qm74 5408 11 patients patient NNS cord-015021-pol2qm74 5408 12 with with IN cord-015021-pol2qm74 5408 13 infectious infectious JJ cord-015021-pol2qm74 5408 14 as as RB cord-015021-pol2qm74 5408 15 well well RB cord-015021-pol2qm74 5408 16 as as IN cord-015021-pol2qm74 5408 17 malignant malignant JJ cord-015021-pol2qm74 5408 18 disorders disorder NNS cord-015021-pol2qm74 5408 19 . . . cord-015021-pol2qm74 5409 1 In in IN cord-015021-pol2qm74 5409 2 patients patient NNS cord-015021-pol2qm74 5409 3 undergoing undergo VBG cord-015021-pol2qm74 5409 4 immune immune JJ cord-015021-pol2qm74 5409 5 stimulatory stimulatory JJ cord-015021-pol2qm74 5409 6 therapy therapy NN cord-015021-pol2qm74 5409 7 with with IN cord-015021-pol2qm74 5409 8 interleukin-2 interleukin-2 NN cord-015021-pol2qm74 5409 9 and and CC cord-015021-pol2qm74 5409 10 interferon interferon NN cord-015021-pol2qm74 5409 11 alpha alpha NN cord-015021-pol2qm74 5409 12 a a DT cord-015021-pol2qm74 5409 13 simultaneous simultaneous JJ cord-015021-pol2qm74 5409 14 increase increase NN cord-015021-pol2qm74 5409 15 of of IN cord-015021-pol2qm74 5409 16 TNF TNF NNP cord-015021-pol2qm74 5409 17 and and CC cord-015021-pol2qm74 5409 18 its -PRON- PRP$ cord-015021-pol2qm74 5409 19 soluble soluble JJ cord-015021-pol2qm74 5409 20 receptors receptor NNS cord-015021-pol2qm74 5409 21 can can MD cord-015021-pol2qm74 5409 22 be be VB cord-015021-pol2qm74 5409 23 seen see VBN cord-015021-pol2qm74 5409 24 . . . cord-015021-pol2qm74 5410 1 In in IN cord-015021-pol2qm74 5410 2 patients patient NNS cord-015021-pol2qm74 5410 3 with with IN cord-015021-pol2qm74 5410 4 HIV HIV NNP cord-015021-pol2qm74 5410 5 infection infection NN cord-015021-pol2qm74 5410 6 a a DT cord-015021-pol2qm74 5410 7 strong strong JJ cord-015021-pol2qm74 5410 8 correlation correlation NN cord-015021-pol2qm74 5410 9 exists exist VBZ cord-015021-pol2qm74 5410 10 between between IN cord-015021-pol2qm74 5410 11 the the DT cord-015021-pol2qm74 5410 12 levels level NNS cord-015021-pol2qm74 5410 13 of of IN cord-015021-pol2qm74 5410 14 sTNF stnf NN cord-015021-pol2qm74 5410 15 - - HYPH cord-015021-pol2qm74 5410 16 Rs r NNS cord-015021-pol2qm74 5410 17 and and CC cord-015021-pol2qm74 5410 18 markers marker NNS cord-015021-pol2qm74 5410 19 of of IN cord-015021-pol2qm74 5410 20 immune immune JJ cord-015021-pol2qm74 5410 21 activation activation NN cord-015021-pol2qm74 5410 22 like like IN cord-015021-pol2qm74 5410 23 neopterin neopterin NNP cord-015021-pol2qm74 5410 24 or or CC cord-015021-pol2qm74 5410 25 beta-2-microglobulin beta-2-microglobulin NNP cord-015021-pol2qm74 5410 26 . . . cord-015021-pol2qm74 5411 1 Likewise likewise RB cord-015021-pol2qm74 5411 2 patients patient NNS cord-015021-pol2qm74 5411 3 with with IN cord-015021-pol2qm74 5411 4 hematological hematological JJ cord-015021-pol2qm74 5411 5 disorders disorder NNS cord-015021-pol2qm74 5411 6 show show VBP cord-015021-pol2qm74 5411 7 elevated elevated JJ cord-015021-pol2qm74 5411 8 sTNF stnf NN cord-015021-pol2qm74 5411 9 - - HYPH cord-015021-pol2qm74 5411 10 R r NN cord-015021-pol2qm74 5411 11 levels level NNS cord-015021-pol2qm74 5411 12 . . . cord-015021-pol2qm74 5412 1 Patients patient NNS cord-015021-pol2qm74 5412 2 with with IN cord-015021-pol2qm74 5412 3 weight weight NN cord-015021-pol2qm74 5412 4 loss loss NN cord-015021-pol2qm74 5412 5 have have VBP cord-015021-pol2qm74 5412 6 higher high JJR cord-015021-pol2qm74 5412 7 concentrations concentration NNS cord-015021-pol2qm74 5412 8 than than IN cord-015021-pol2qm74 5412 9 patients patient NNS cord-015021-pol2qm74 5412 10 with with IN cord-015021-pol2qm74 5412 11 stable stable JJ cord-015021-pol2qm74 5412 12 weight weight NN cord-015021-pol2qm74 5412 13 . . . cord-015021-pol2qm74 5413 1 The the DT cord-015021-pol2qm74 5413 2 final final JJ cord-015021-pol2qm74 5413 3 value value NN cord-015021-pol2qm74 5413 4 of of IN cord-015021-pol2qm74 5413 5 sTNF stnf NN cord-015021-pol2qm74 5413 6 - - HYPH cord-015021-pol2qm74 5413 7 Rs r NNS cord-015021-pol2qm74 5413 8 within within IN cord-015021-pol2qm74 5413 9 the the DT cord-015021-pol2qm74 5413 10 complex complex JJ cord-015021-pol2qm74 5413 11 network network NN cord-015021-pol2qm74 5413 12 of of IN cord-015021-pol2qm74 5413 13 cytokines cytokine NNS cord-015021-pol2qm74 5413 14 is be VBZ cord-015021-pol2qm74 5413 15 not not RB cord-015021-pol2qm74 5413 16 yet yet RB cord-015021-pol2qm74 5413 17 clear clear JJ cord-015021-pol2qm74 5413 18 . . . cord-015021-pol2qm74 5414 1 However however RB cord-015021-pol2qm74 5414 2 , , , cord-015021-pol2qm74 5414 3 there there EX cord-015021-pol2qm74 5414 4 exist exist VBP cord-015021-pol2qm74 5414 5 striking strike VBG cord-015021-pol2qm74 5414 6 parallels parallel NNS cord-015021-pol2qm74 5414 7 between between IN cord-015021-pol2qm74 5414 8 infectious infectious JJ cord-015021-pol2qm74 5414 9 and and CC cord-015021-pol2qm74 5414 10 malignant malignant JJ cord-015021-pol2qm74 5414 11 disorders disorder NNS cord-015021-pol2qm74 5414 12 pointing point VBG cord-015021-pol2qm74 5414 13 to to IN cord-015021-pol2qm74 5414 14 a a DT cord-015021-pol2qm74 5414 15 key key JJ cord-015021-pol2qm74 5414 16 role role NN cord-015021-pol2qm74 5414 17 of of IN cord-015021-pol2qm74 5414 18 endogenous endogenous JJ cord-015021-pol2qm74 5414 19 immune immune JJ cord-015021-pol2qm74 5414 20 activation activation NN cord-015021-pol2qm74 5414 21 . . . cord-015021-pol2qm74 5415 1 Biochemicatly Biochemicatly NNP cord-015021-pol2qm74 5415 2 , , , cord-015021-pol2qm74 5415 3 D D NNP cord-015021-pol2qm74 5415 4 - - HYPH cord-015021-pol2qm74 5415 5 erythro erythro JJ cord-015021-pol2qm74 5415 6 - - HYPH cord-015021-pol2qm74 5415 7 neopterin neopterin NN cord-015021-pol2qm74 5415 8 derives derive VBZ cord-015021-pol2qm74 5415 9 from from IN cord-015021-pol2qm74 5415 10 guanosine guanosine NN cord-015021-pol2qm74 5415 11 triphosphate triphosphate NN cord-015021-pol2qm74 5415 12 . . . cord-015021-pol2qm74 5416 1 In in IN cord-015021-pol2qm74 5416 2 vitro vitro FW cord-015021-pol2qm74 5416 3 studies study NNS cord-015021-pol2qm74 5416 4 show show VBP cord-015021-pol2qm74 5416 5 that that IN cord-015021-pol2qm74 5416 6 large large JJ cord-015021-pol2qm74 5416 7 amounts amount NNS cord-015021-pol2qm74 5416 8 of of IN cord-015021-pol2qm74 5416 9 neopterin neopterin NNS cord-015021-pol2qm74 5416 10 are be VBP cord-015021-pol2qm74 5416 11 produced produce VBN cord-015021-pol2qm74 5416 12 by by IN cord-015021-pol2qm74 5416 13 human human JJ cord-015021-pol2qm74 5416 14 monocytes monocyte NNS cord-015021-pol2qm74 5416 15 / / SYM cord-015021-pol2qm74 5416 16 macrophages macrophage NNS cord-015021-pol2qm74 5416 17 stimulated stimulate VBN cord-015021-pol2qm74 5416 18 with with IN cord-015021-pol2qm74 5416 19 interferon interferon NN cord-015021-pol2qm74 5416 20 - - HYPH cord-015021-pol2qm74 5416 21 j j NNP cord-015021-pol2qm74 5416 22 ( ( -LRB- cord-015021-pol2qm74 5416 23 IFN IFN NNP cord-015021-pol2qm74 5416 24 - - HYPH cord-015021-pol2qm74 5416 25 J J NNP cord-015021-pol2qm74 5416 26 ) ) -RRB- cord-015021-pol2qm74 5416 27 . . . cord-015021-pol2qm74 5417 1 Neopterin Neopterin NNP cord-015021-pol2qm74 5417 2 is be VBZ cord-015021-pol2qm74 5417 3 biologically biologically RB cord-015021-pol2qm74 5417 4 stable stable JJ cord-015021-pol2qm74 5417 5 , , , cord-015021-pol2qm74 5417 6 and and CC cord-015021-pol2qm74 5417 7 its -PRON- PRP$ cord-015021-pol2qm74 5417 8 halflife halflife NN cord-015021-pol2qm74 5417 9 in in IN cord-015021-pol2qm74 5417 10 the the DT cord-015021-pol2qm74 5417 11 blood blood NN cord-015021-pol2qm74 5417 12 seems seem VBZ cord-015021-pol2qm74 5417 13 to to TO cord-015021-pol2qm74 5417 14 solely solely RB cord-015021-pol2qm74 5417 15 depend depend VB cord-015021-pol2qm74 5417 16 on on IN cord-015021-pol2qm74 5417 17 renal renal JJ cord-015021-pol2qm74 5417 18 excretion excretion NN cord-015021-pol2qm74 5417 19 . . . cord-015021-pol2qm74 5418 1 Specimen specimen JJ cord-015021-pol2qm74 5418 2 for for IN cord-015021-pol2qm74 5418 3 neopterin neopterin JJ cord-015021-pol2qm74 5418 4 determination determination NN cord-015021-pol2qm74 5418 5 can can MD cord-015021-pol2qm74 5418 6 be be VB cord-015021-pol2qm74 5418 7 stored store VBN cord-015021-pol2qm74 5418 8 without without IN cord-015021-pol2qm74 5418 9 special special JJ cord-015021-pol2qm74 5418 10 precautions precaution NNS cord-015021-pol2qm74 5418 11 . . . cord-015021-pol2qm74 5419 1 Increased increase VBN cord-015021-pol2qm74 5419 2 concentrations concentration NNS cord-015021-pol2qm74 5419 3 of of IN cord-015021-pol2qm74 5419 4 neopterin neopterin NNP cord-015021-pol2qm74 5419 5 have have VBP cord-015021-pol2qm74 5419 6 been be VBN cord-015021-pol2qm74 5419 7 described describe VBN cord-015021-pol2qm74 5419 8 in in IN cord-015021-pol2qm74 5419 9 body body NN cord-015021-pol2qm74 5419 10 fluids fluid NNS cord-015021-pol2qm74 5419 11 of of IN cord-015021-pol2qm74 5419 12 patients patient NNS cord-015021-pol2qm74 5419 13 suffering suffer VBG cord-015021-pol2qm74 5419 14 from from IN cord-015021-pol2qm74 5419 15 diseases disease NNS cord-015021-pol2qm74 5419 16 which which WDT cord-015021-pol2qm74 5419 17 are be VBP cord-015021-pol2qm74 5419 18 apparently apparently RB cord-015021-pol2qm74 5419 19 associated associate VBN cord-015021-pol2qm74 5419 20 with with IN cord-015021-pol2qm74 5419 21 an an DT cord-015021-pol2qm74 5419 22 activated activate VBN cord-015021-pol2qm74 5419 23 cellular cellular JJ cord-015021-pol2qm74 5419 24 immune immune JJ cord-015021-pol2qm74 5419 25 response response NN cord-015021-pol2qm74 5419 26 and and CC cord-015021-pol2qm74 5419 27 with with IN cord-015021-pol2qm74 5419 28 enhanced enhanced JJ cord-015021-pol2qm74 5419 29 endogenous endogenous JJ cord-015021-pol2qm74 5419 30 formation formation NN cord-015021-pol2qm74 5419 31 of of IN cord-015021-pol2qm74 5419 32 IFN-~ IFN-~ NNP cord-015021-pol2qm74 5419 33 ' ' '' cord-015021-pol2qm74 5419 34 , , , cord-015021-pol2qm74 5419 35 e.g e.g NNP cord-015021-pol2qm74 5419 36 , , , cord-015021-pol2qm74 5419 37 , , , cord-015021-pol2qm74 5419 38 1 1 CD cord-015021-pol2qm74 5419 39 ) ) -RRB- cord-015021-pol2qm74 5419 40 increasing increase VBG cord-015021-pol2qm74 5419 41 neopterin neopterin JJ cord-015021-pol2qm74 5419 42 levels level NNS cord-015021-pol2qm74 5419 43 predict predict VBP cord-015021-pol2qm74 5419 44 rejection rejection NN cord-015021-pol2qm74 5419 45 episodes episode NNS cord-015021-pol2qm74 5419 46 in in IN cord-015021-pol2qm74 5419 47 allograft allograft NN cord-015021-pol2qm74 5419 48 recipients recipient NNS cord-015021-pol2qm74 5419 49 2 2 LS cord-015021-pol2qm74 5419 50 ) ) -RRB- cord-015021-pol2qm74 5419 51 virus virus NN cord-015021-pol2qm74 5419 52 infections infection NNS cord-015021-pol2qm74 5419 53 induce induce VBP cord-015021-pol2qm74 5419 54 increased increase VBN cord-015021-pol2qm74 5419 55 neopterin neopterin JJ cord-015021-pol2qm74 5419 56 concentrations concentration NNS cord-015021-pol2qm74 5419 57 , , , cord-015021-pol2qm74 5419 58 and and CC cord-015021-pol2qm74 5419 59 the the DT cord-015021-pol2qm74 5419 60 degree degree NN cord-015021-pol2qm74 5419 61 of of IN cord-015021-pol2qm74 5419 62 neopterin neopterin NNP cord-015021-pol2qm74 5419 63 elevation elevation NNP cord-015021-pol2qm74 5419 64 predicts predict VBZ cord-015021-pol2qm74 5419 65 prognosis prognosis NN cord-015021-pol2qm74 5419 66 in in IN cord-015021-pol2qm74 5419 67 these these DT cord-015021-pol2qm74 5419 68 patients patient NNS cord-015021-pol2qm74 5419 69 which which WDT cord-015021-pol2qm74 5419 70 is be VBZ cord-015021-pol2qm74 5419 71 particularly particularly RB cord-015021-pol2qm74 5419 72 true true JJ cord-015021-pol2qm74 5419 73 in in IN cord-015021-pol2qm74 5419 74 HIV-1 HIV-1 NNP cord-015021-pol2qm74 5419 75 infection infection NN cord-015021-pol2qm74 5419 76 3 3 CD cord-015021-pol2qm74 5419 77 ) ) -RRB- cord-015021-pol2qm74 5419 78 in in IN cord-015021-pol2qm74 5419 79 autoimmune autoimmune JJ cord-015021-pol2qm74 5419 80 disorders disorder NNS cord-015021-pol2qm74 5419 81 such such JJ cord-015021-pol2qm74 5419 82 as as IN cord-015021-pol2qm74 5419 83 systemic systemic JJ cord-015021-pol2qm74 5419 84 lupus lupus NN cord-015021-pol2qm74 5419 85 erythematosus erythematosus NN cord-015021-pol2qm74 5419 86 or or CC cord-015021-pol2qm74 5419 87 rheumatoid rheumatoid NN cord-015021-pol2qm74 5419 88 arthritis arthritis NN cord-015021-pol2qm74 5419 89 neopterin neopterin NNP cord-015021-pol2qm74 5419 90 levels level NNS cord-015021-pol2qm74 5419 91 reflect reflect VBP cord-015021-pol2qm74 5419 92 activity activity NN cord-015021-pol2qm74 5419 93 of of IN cord-015021-pol2qm74 5419 94 the the DT cord-015021-pol2qm74 5419 95 disease disease NN cord-015021-pol2qm74 5419 96 4 4 CD cord-015021-pol2qm74 5419 97 ) ) -RRB- cord-015021-pol2qm74 5419 98 increased increase VBD cord-015021-pol2qm74 5419 99 neopterin neopterin JJ cord-015021-pol2qm74 5419 100 concentrations concentration NNS cord-015021-pol2qm74 5419 101 in in IN cord-015021-pol2qm74 5419 102 patients patient NNS cord-015021-pol2qm74 5419 103 suffering suffer VBG cord-015021-pol2qm74 5419 104 from from IN cord-015021-pol2qm74 5419 105 certain certain JJ cord-015021-pol2qm74 5419 106 types type NNS cord-015021-pol2qm74 5419 107 of of IN cord-015021-pol2qm74 5419 108 cancer cancer NN cord-015021-pol2qm74 5419 109 indicate indicate VBP cord-015021-pol2qm74 5419 110 poor poor JJ cord-015021-pol2qm74 5419 111 prognosis prognosis NN cord-015021-pol2qm74 5419 112 . . . cord-015021-pol2qm74 5420 1 Significant significant JJ cord-015021-pol2qm74 5420 2 associations association NNS cord-015021-pol2qm74 5420 3 between between IN cord-015021-pol2qm74 5420 4 changes change NNS cord-015021-pol2qm74 5420 5 of of IN cord-015021-pol2qm74 5420 6 neopterin neopterin NN cord-015021-pol2qm74 5420 7 and and CC cord-015021-pol2qm74 5420 8 decrease decrease NN cord-015021-pol2qm74 5420 9 of of IN cord-015021-pol2qm74 5420 10 hemoglobin hemoglobin NN cord-015021-pol2qm74 5420 11 as as RB cord-015021-pol2qm74 5420 12 well well RB cord-015021-pol2qm74 5420 13 as as IN cord-015021-pol2qm74 5420 14 the the DT cord-015021-pol2qm74 5420 15 development development NN cord-015021-pol2qm74 5420 16 of of IN cord-015021-pol2qm74 5420 17 weight weight NN cord-015021-pol2qm74 5420 18 loss loss NN cord-015021-pol2qm74 5420 19 and and CC cord-015021-pol2qm74 5420 20 cachexia cachexia NN cord-015021-pol2qm74 5420 21 , , , cord-015021-pol2qm74 5420 22 e.g. e.g. RB cord-015021-pol2qm74 5420 23 , , , cord-015021-pol2qm74 5420 24 in in IN cord-015021-pol2qm74 5420 25 cancer cancer NN cord-015021-pol2qm74 5420 26 patients patient NNS cord-015021-pol2qm74 5420 27 and and CC cord-015021-pol2qm74 5420 28 in in IN cord-015021-pol2qm74 5420 29 patients patient NNS cord-015021-pol2qm74 5420 30 with with IN cord-015021-pol2qm74 5420 31 HIV-1 HIV-1 NNP cord-015021-pol2qm74 5420 32 infection infection NN cord-015021-pol2qm74 5420 33 , , , cord-015021-pol2qm74 5420 34 support support VB cord-015021-pol2qm74 5420 35 the the DT cord-015021-pol2qm74 5420 36 concept concept NN cord-015021-pol2qm74 5420 37 that that WDT cord-015021-pol2qm74 5420 38 endogenously endogenously RB cord-015021-pol2qm74 5420 39 formed form VBD cord-015021-pol2qm74 5420 40 cytokines cytokine NNS cord-015021-pol2qm74 5420 41 such such JJ cord-015021-pol2qm74 5420 42 as as IN cord-015021-pol2qm74 5420 43 IFN-~ IFN-~ NNP cord-015021-pol2qm74 5420 44 " " '' cord-015021-pol2qm74 5420 45 and and CC cord-015021-pol2qm74 5420 46 tumor tumor NN cord-015021-pol2qm74 5420 47 necrosis necrosis NN cord-015021-pol2qm74 5420 48 factor-~ factor-~ NNP cord-015021-pol2qm74 5420 49 ( ( -LRB- cord-015021-pol2qm74 5420 50 are be VBP cord-015021-pol2qm74 5420 51 involved involve VBN cord-015021-pol2qm74 5420 52 in in IN cord-015021-pol2qm74 5420 53 the the DT cord-015021-pol2qm74 5420 54 pathogenesis pathogenesis NN cord-015021-pol2qm74 5420 55 of of IN cord-015021-pol2qm74 5420 56 such such JJ cord-015021-pol2qm74 5420 57 symptoms symptom NNS cord-015021-pol2qm74 5420 58 . . . cord-015021-pol2qm74 5421 1 In in IN cord-015021-pol2qm74 5421 2 conclusion conclusion NN cord-015021-pol2qm74 5421 3 , , , cord-015021-pol2qm74 5421 4 neopterin neopterin JJ cord-015021-pol2qm74 5421 5 monitoring monitoring NN cord-015021-pol2qm74 5421 6 is be VBZ cord-015021-pol2qm74 5421 7 a a DT cord-015021-pol2qm74 5421 8 sensitive sensitive JJ cord-015021-pol2qm74 5421 9 tool tool NN cord-015021-pol2qm74 5421 10 to to TO cord-015021-pol2qm74 5421 11 detect detect VB cord-015021-pol2qm74 5421 12 the the DT cord-015021-pol2qm74 5421 13 activation activation NN cord-015021-pol2qm74 5421 14 status status NN cord-015021-pol2qm74 5421 15 of of IN cord-015021-pol2qm74 5421 16 the the DT cord-015021-pol2qm74 5421 17 cell cell NN cord-015021-pol2qm74 5421 18 - - HYPH cord-015021-pol2qm74 5421 19 mediated mediate VBN cord-015021-pol2qm74 5421 20 immune immune JJ cord-015021-pol2qm74 5421 21 system system NN cord-015021-pol2qm74 5421 22 in in IN cord-015021-pol2qm74 5421 23 vivo vivo NNP cord-015021-pol2qm74 5421 24 . . . cord-015021-pol2qm74 5422 1 Repair repair NN cord-015021-pol2qm74 5422 2 and and CC cord-015021-pol2qm74 5422 3 healing healing NN cord-015021-pol2qm74 5422 4 or or CC cord-015021-pol2qm74 5422 5 perpetuation perpetuation NN cord-015021-pol2qm74 5422 6 of of IN cord-015021-pol2qm74 5422 7 acute acute JJ cord-015021-pol2qm74 5422 8 inflammation inflammation NN cord-015021-pol2qm74 5422 9 is be VBZ cord-015021-pol2qm74 5422 10 characterized characterize VBN cord-015021-pol2qm74 5422 11 by by IN cord-015021-pol2qm74 5422 12 a a DT cord-015021-pol2qm74 5422 13 complex complex JJ cord-015021-pol2qm74 5422 14 network network NN cord-015021-pol2qm74 5422 15 of of IN cord-015021-pol2qm74 5422 16 interacting interact VBG cord-015021-pol2qm74 5422 17 cellular cellular JJ cord-015021-pol2qm74 5422 18 and and CC cord-015021-pol2qm74 5422 19 humoral humoral JJ cord-015021-pol2qm74 5422 20 defence defence NN cord-015021-pol2qm74 5422 21 mechanisms mechanism NNS cord-015021-pol2qm74 5422 22 . . . cord-015021-pol2qm74 5423 1 Of of IN cord-015021-pol2qm74 5423 2 the the DT cord-015021-pol2qm74 5423 3 numerous numerous JJ cord-015021-pol2qm74 5423 4 inflammatory inflammatory JJ cord-015021-pol2qm74 5423 5 mediators mediator NNS cord-015021-pol2qm74 5423 6 / / SYM cord-015021-pol2qm74 5423 7 effectors effector NNS cord-015021-pol2qm74 5423 8 investigated investigate VBN cord-015021-pol2qm74 5423 9 hitherto hitherto VBN cord-015021-pol2qm74 5423 10 , , , cord-015021-pol2qm74 5423 11 the the DT cord-015021-pol2qm74 5423 12 proteolydc proteolydc JJ cord-015021-pol2qm74 5423 13 lysosomal lysosomal JJ cord-015021-pol2qm74 5423 14 enzyme enzyme NN cord-015021-pol2qm74 5423 15 PMN PMN NNP cord-015021-pol2qm74 5423 16 elastase elastase NN cord-015021-pol2qm74 5423 17 has have VBZ cord-015021-pol2qm74 5423 18 turned turn VBN cord-015021-pol2qm74 5423 19 out out RP cord-015021-pol2qm74 5423 20 to to TO cord-015021-pol2qm74 5423 21 be be VB cord-015021-pol2qm74 5423 22 highly highly RB cord-015021-pol2qm74 5423 23 destructive destructive JJ cord-015021-pol2qm74 5423 24 when when WRB cord-015021-pol2qm74 5423 25 released release VBN cord-015021-pol2qm74 5423 26 extracellularly extracellularly RB cord-015021-pol2qm74 5423 27 thus thus RB cord-015021-pol2qm74 5423 28 contributing contribute VBG cord-015021-pol2qm74 5423 29 considm considm NNP cord-015021-pol2qm74 5423 30 : : : cord-015021-pol2qm74 5423 31 ably ably RB cord-015021-pol2qm74 5423 32 to to IN cord-015021-pol2qm74 5423 33 organ organ NN cord-015021-pol2qm74 5423 34 dysfunctions dysfunction NNS cord-015021-pol2qm74 5423 35 in in IN cord-015021-pol2qm74 5423 36 severe severe JJ cord-015021-pol2qm74 5423 37 posttraumatic posttraumatic JJ cord-015021-pol2qm74 5423 38 and and CC cord-015021-pol2qm74 5423 39 postoperative postoperative JJ cord-015021-pol2qm74 5423 40 courses course NNS cord-015021-pol2qm74 5423 41 . . . cord-015021-pol2qm74 5424 1 Besides besides IN cord-015021-pol2qm74 5424 2 various various JJ cord-015021-pol2qm74 5424 3 cytokines cytokine NNS cord-015021-pol2qm74 5424 4 , , , cord-015021-pol2qm74 5424 5 elastase elastase NN cord-015021-pol2qm74 5424 6 in in IN cord-015021-pol2qm74 5424 7 complex complex NN cord-015021-pol2qm74 5424 8 with with IN cord-015021-pol2qm74 5424 9 its -PRON- PRP$ cord-015021-pol2qm74 5424 10 main main JJ cord-015021-pol2qm74 5424 11 antagonist antagonist NN cord-015021-pol2qm74 5425 1 c¢ c¢ NNP cord-015021-pol2qm74 5426 1 1-proteinase 1-proteinase CD cord-015021-pol2qm74 5426 2 inhibitor inhibitor NN cord-015021-pol2qm74 5426 3 ( ( -LRB- cord-015021-pol2qm74 5426 4 a a DT cord-015021-pol2qm74 5426 5 1PI 1pi CD cord-015021-pol2qm74 5426 6 ) ) -RRB- cord-015021-pol2qm74 5426 7 is be VBZ cord-015021-pol2qm74 5426 8 also also RB cord-015021-pol2qm74 5426 9 supposed suppose VBN cord-015021-pol2qm74 5426 10 to to TO cord-015021-pol2qm74 5426 11 induce induce VB cord-015021-pol2qm74 5426 12 the the DT cord-015021-pol2qm74 5426 13 shedding shedding NN cord-015021-pol2qm74 5426 14 of of IN cord-015021-pol2qm74 5426 15 intercellular intercellular JJ cord-015021-pol2qm74 5426 16 adhesion adhesion NN cord-015021-pol2qm74 5426 17 molecules molecule NNS cord-015021-pol2qm74 5426 18 from from IN cord-015021-pol2qm74 5426 19 inflammatory inflammatory JJ cord-015021-pol2qm74 5426 20 cells cell NNS cord-015021-pol2qm74 5426 21 ( ( -LRB- cord-015021-pol2qm74 5426 22 PMNs pmn NNS cord-015021-pol2qm74 5426 23 , , , cord-015021-pol2qm74 5426 24 monocytes monocyte NNS cord-015021-pol2qm74 5426 25 / / SYM cord-015021-pol2qm74 5426 26 macrophages macrophage NNS cord-015021-pol2qm74 5426 27 , , , cord-015021-pol2qm74 5426 28 endothelial endothelial JJ cord-015021-pol2qm74 5426 29 cells cell NNS cord-015021-pol2qm74 5426 30 ) ) -RRB- cord-015021-pol2qm74 5426 31 . . . cord-015021-pol2qm74 5427 1 These these DT cord-015021-pol2qm74 5427 2 soluble soluble JJ cord-015021-pol2qm74 5427 3 adhesion adhesion NN cord-015021-pol2qm74 5427 4 molecules molecule NNS cord-015021-pol2qm74 5427 5 may may MD cord-015021-pol2qm74 5427 6 modulate modulate VB cord-015021-pol2qm74 5427 7 the the DT cord-015021-pol2qm74 5427 8 inflammatory inflammatory JJ cord-015021-pol2qm74 5427 9 process process NN cord-015021-pol2qm74 5427 10 in in IN cord-015021-pol2qm74 5427 11 many many JJ cord-015021-pol2qm74 5427 12 different different JJ cord-015021-pol2qm74 5427 13 ways way NNS cord-015021-pol2qm74 5427 14 , , , cord-015021-pol2qm74 5427 15 e.g. e.g. RB cord-015021-pol2qm74 5427 16 via via IN cord-015021-pol2qm74 5427 17 acting act VBG cord-015021-pol2qm74 5427 18 as as IN cord-015021-pol2qm74 5427 19 chemotaxins chemotaxins NNP cord-015021-pol2qm74 5427 20 , , , cord-015021-pol2qm74 5427 21 blocking block VBG cord-015021-pol2qm74 5427 22 neutrophil neutrophil NN cord-015021-pol2qm74 5427 23 activation activation NN cord-015021-pol2qm74 5427 24 or or CC cord-015021-pol2qm74 5427 25 competing compete VBG cord-015021-pol2qm74 5427 26 with with IN cord-015021-pol2qm74 5427 27 the the DT cord-015021-pol2qm74 5427 28 membrane membrane NN cord-015021-pol2qm74 5427 29 - - HYPH cord-015021-pol2qm74 5427 30 bound bind VBN cord-015021-pol2qm74 5427 31 forms form NNS cord-015021-pol2qm74 5427 32 in in IN cord-015021-pol2qm74 5427 33 cell cell NN cord-015021-pol2qm74 5427 34 - - HYPH cord-015021-pol2qm74 5427 35 cell cell NN cord-015021-pol2qm74 5427 36 adhesion adhesion NN cord-015021-pol2qm74 5427 37 . . . cord-015021-pol2qm74 5428 1 Thus thus RB cord-015021-pol2qm74 5428 2 , , , cord-015021-pol2qm74 5428 3 measuring measure VBG cord-015021-pol2qm74 5428 4 circulating circulate VBG cord-015021-pol2qm74 5428 5 or or CC cord-015021-pol2qm74 5428 6 local local JJ cord-015021-pol2qm74 5428 7 levels level NNS cord-015021-pol2qm74 5428 8 of of IN cord-015021-pol2qm74 5428 9 elastase elastase NN cord-015021-pol2qm74 5428 10 - - : cord-015021-pol2qm74 5428 11 a a DT cord-015021-pol2qm74 5428 12 1PI 1pi CD cord-015021-pol2qm74 5428 13 and and CC cord-015021-pol2qm74 5428 14 soluble soluble JJ cord-015021-pol2qm74 5428 15 adhesion adhesion NN cord-015021-pol2qm74 5428 16 molecules molecule NNS cord-015021-pol2qm74 5428 17 ( ( -LRB- cord-015021-pol2qm74 5428 18 ICAM ICAM NNP cord-015021-pol2qm74 5428 19 , , , cord-015021-pol2qm74 5428 20 E E NNP cord-015021-pol2qm74 5428 21 - - NN cord-015021-pol2qm74 5428 22 selectin,-Pselectin selectin,-pselectin RB cord-015021-pol2qm74 5428 23 , , , cord-015021-pol2qm74 5428 24 L l NN cord-015021-pol2qm74 5428 25 - - HYPH cord-015021-pol2qm74 5428 26 selectin selectin NNP cord-015021-pol2qm74 5428 27 ) ) -RRB- cord-015021-pol2qm74 5428 28 may may MD cord-015021-pol2qm74 5428 29 be be VB cord-015021-pol2qm74 5428 30 a a DT cord-015021-pol2qm74 5428 31 helpful helpful JJ cord-015021-pol2qm74 5428 32 tool tool NN cord-015021-pol2qm74 5428 33 in in IN cord-015021-pol2qm74 5428 34 judging judge VBG cord-015021-pol2qm74 5428 35 the the DT cord-015021-pol2qm74 5428 36 severity severity NN cord-015021-pol2qm74 5428 37 of of IN cord-015021-pol2qm74 5428 38 an an DT cord-015021-pol2qm74 5428 39 acute acute JJ cord-015021-pol2qm74 5428 40 inflammatory inflammatory JJ cord-015021-pol2qm74 5428 41 process process NN cord-015021-pol2qm74 5428 42 . . . cord-015021-pol2qm74 5429 1 In in IN cord-015021-pol2qm74 5429 2 several several JJ cord-015021-pol2qm74 5429 3 clinical clinical JJ cord-015021-pol2qm74 5429 4 studies study NNS cord-015021-pol2qm74 5429 5 on on IN cord-015021-pol2qm74 5429 6 surgical surgical JJ cord-015021-pol2qm74 5429 7 patients patient NNS cord-015021-pol2qm74 5429 8 suffering suffer VBG cord-015021-pol2qm74 5429 9 from from IN cord-015021-pol2qm74 5429 10 multiple multiple JJ cord-015021-pol2qm74 5429 11 trauma trauma NN cord-015021-pol2qm74 5429 12 and/or and/or CC cord-015021-pol2qm74 5429 13 sepsis sepsis NN cord-015021-pol2qm74 5429 14 we -PRON- PRP cord-015021-pol2qm74 5429 15 could could MD cord-015021-pol2qm74 5429 16 demonstrate demonstrate VB cord-015021-pol2qm74 5429 17 that that IN cord-015021-pol2qm74 5429 18 the the DT cord-015021-pol2qm74 5429 19 measurement measurement NN cord-015021-pol2qm74 5429 20 of of IN cord-015021-pol2qm74 5429 21 these these DT cord-015021-pol2qm74 5429 22 parameters parameter NNS cord-015021-pol2qm74 5429 23 in in IN cord-015021-pol2qm74 5429 24 consecutive consecutive JJ cord-015021-pol2qm74 5429 25 plasma plasma NN cord-015021-pol2qm74 5429 26 samples sample NNS cord-015021-pol2qm74 5429 27 and and CC cord-015021-pol2qm74 5429 28 local local JJ cord-015021-pol2qm74 5429 29 body body NN cord-015021-pol2qm74 5429 30 fluids fluid NNS cord-015021-pol2qm74 5429 31 was be VBD cord-015021-pol2qm74 5429 32 highly highly RB cord-015021-pol2qm74 5429 33 valuable valuable JJ cord-015021-pol2qm74 5429 34 for for IN cord-015021-pol2qm74 5429 35 early early JJ cord-015021-pol2qm74 5429 36 diagnosis diagnosis NN cord-015021-pol2qm74 5429 37 and and CC cord-015021-pol2qm74 5429 38 prognosis prognosis NN cord-015021-pol2qm74 5429 39 of of IN cord-015021-pol2qm74 5429 40 multiple multiple JJ cord-015021-pol2qm74 5429 41 organ organ NN cord-015021-pol2qm74 5429 42 failure failure NN cord-015021-pol2qm74 5429 43 . . . cord-015021-pol2qm74 5430 1 Prof. Prof. NNP cord-015021-pol2qm74 5430 2 Dr. Dr. NNP cord-015021-pol2qm74 5430 3 M./ochum M./ochum NNP cord-015021-pol2qm74 5430 4 , , , cord-015021-pol2qm74 5430 5 Institut Institut NNP cord-015021-pol2qm74 5430 6 Fdr Fdr NNP cord-015021-pol2qm74 5430 7 klinischeChemie klinischeChemie NNP cord-015021-pol2qm74 5430 8 und und IN cord-015021-pol2qm74 5430 9 Biochemie Biochemie NNP cord-015021-pol2qm74 5430 10 , , , cord-015021-pol2qm74 5431 1 LMU LMU NNP cord-015021-pol2qm74 5431 2 Miinchen Miinchen NNP cord-015021-pol2qm74 5431 3 , , , cord-015021-pol2qm74 5431 4 Nufibaumstrage Nufibaumstrage NNP cord-015021-pol2qm74 5431 5 20 20 CD cord-015021-pol2qm74 5431 6 , , , cord-015021-pol2qm74 5431 7 80336 80336 CD cord-015021-pol2qm74 5432 1 M0nchen M0nchen NNP cord-015021-pol2qm74 5432 2 , , , cord-015021-pol2qm74 5432 3 Germany Germany NNP cord-015021-pol2qm74 5432 4 Procalaitonin Procalaitonin NNP cord-015021-pol2qm74 5432 5 ( ( -LRB- cord-015021-pol2qm74 5432 6 ProCT ProCT NNP cord-015021-pol2qm74 5432 7 ) ) -RRB- cord-015021-pol2qm74 5432 8 a a DT cord-015021-pol2qm74 5432 9 116 116 CD cord-015021-pol2qm74 5432 10 AA AA NNP cord-015021-pol2qm74 5432 11 peptide peptide NN cord-015021-pol2qm74 5432 12 is be VBZ cord-015021-pol2qm74 5432 13 dramatically dramatically RB cord-015021-pol2qm74 5432 14 increased increase VBN cord-015021-pol2qm74 5432 15 in in IN cord-015021-pol2qm74 5432 16 the the DT cord-015021-pol2qm74 5432 17 blood blood NN cord-015021-pol2qm74 5432 18 of of IN cord-015021-pol2qm74 5432 19 patients patient NNS cord-015021-pol2qm74 5432 20 with with IN cord-015021-pol2qm74 5432 21 various various JJ cord-015021-pol2qm74 5432 22 sepsis sepsis NN cord-015021-pol2qm74 5432 23 and and CC cord-015021-pol2qm74 5432 24 infections infection NNS cord-015021-pol2qm74 5432 25 . . . cord-015021-pol2qm74 5433 1 The the DT cord-015021-pol2qm74 5433 2 increase increase NN cord-015021-pol2qm74 5433 3 begins begin VBZ cord-015021-pol2qm74 5433 4 as as RB cord-015021-pol2qm74 5433 5 soon soon RB cord-015021-pol2qm74 5433 6 as as IN cord-015021-pol2qm74 5433 7 3 3 CD cord-015021-pol2qm74 5433 8 hours hour NNS cord-015021-pol2qm74 5433 9 after after IN cord-015021-pol2qm74 5433 10 the the DT cord-015021-pol2qm74 5433 11 andoto andoto NN cord-015021-pol2qm74 5433 12 : : : cord-015021-pol2qm74 5433 13 edn edn NNP cord-015021-pol2qm74 5433 14 release release NN cord-015021-pol2qm74 5433 15 and and CC cord-015021-pol2qm74 5433 16 readied readie VBD cord-015021-pol2qm74 5433 17 maximal maximal JJ cord-015021-pol2qm74 5433 18 level level NN cord-015021-pol2qm74 5433 19 with with IN cord-015021-pol2qm74 5433 20 a a DT cord-015021-pol2qm74 5433 21 200 200 CD cord-015021-pol2qm74 5433 22 to to IN cord-015021-pol2qm74 5433 23 80B 80b NN cord-015021-pol2qm74 5433 24 - - : cord-015021-pol2qm74 5433 25 fold fold RB cord-015021-pol2qm74 5433 26 increase increase NN cord-015021-pol2qm74 5433 27 24 24 CD cord-015021-pol2qm74 5433 28 h h NN cord-015021-pol2qm74 5433 29 after after IN cord-015021-pol2qm74 5433 30 LI~ LI~ NNP cord-015021-pol2qm74 5433 31 edrmrdstration edrmrdstration NN cord-015021-pol2qm74 5433 32 . . . cord-015021-pol2qm74 5434 1 Prcc Prcc NNP cord-015021-pol2qm74 5434 2 , , , cord-015021-pol2qm74 5434 3 alcitorfin alcitorfin NN cord-015021-pol2qm74 5434 4 response response NN cord-015021-pol2qm74 5434 5 was be VBD cord-015021-pol2qm74 5434 6 temporally temporally RB cord-015021-pol2qm74 5434 7 different different JJ cord-015021-pol2qm74 5434 8 from from IN cord-015021-pol2qm74 5434 9 these these DT cord-015021-pol2qm74 5434 10 of of IN cord-015021-pol2qm74 5434 11 TNF~ tnf~ CD cord-015021-pol2qm74 5434 12 and and CC cord-015021-pol2qm74 5434 13 II-6 II-6 NNP cord-015021-pol2qm74 5434 14 , , , cord-015021-pol2qm74 5434 15 that that WDT cord-015021-pol2qm74 5434 16 reached reach VBD cord-015021-pol2qm74 5434 17 peak peak NN cord-015021-pol2qm74 5434 18 levels level NNS cord-015021-pol2qm74 5434 19 at at IN cord-015021-pol2qm74 5434 20 2 2 CD cord-015021-pol2qm74 5434 21 h h NN cord-015021-pol2qm74 5434 22 and and CC cord-015021-pol2qm74 5434 23 3 3 CD cord-015021-pol2qm74 5434 24 h h NN cord-015021-pol2qm74 5434 25 respectively respectively RB cord-015021-pol2qm74 5434 26 . . . cord-015021-pol2qm74 5435 1 At at IN cord-015021-pol2qm74 5435 2 the the DT cord-015021-pol2qm74 5435 3 opposite opposite NN cord-015021-pol2qm74 5435 4 of of IN cord-015021-pol2qm74 5435 5 eytokine eytokine NNP cord-015021-pol2qm74 5435 6 ( ( -LRB- cord-015021-pol2qm74 5435 7 TNFcz TNFcz NNP cord-015021-pol2qm74 5435 8 , , , cord-015021-pol2qm74 5435 9 ILd ILd NNP cord-015021-pol2qm74 5435 10 , , , cord-015021-pol2qm74 5435 11 J J NNP cord-015021-pol2qm74 5435 12 , , , cord-015021-pol2qm74 5435 13 Is be VBZ cord-015021-pol2qm74 5435 14 ) ) -RRB- cord-015021-pol2qm74 5435 15 , , , cord-015021-pol2qm74 5435 16 ProCT ProCT NNP cord-015021-pol2qm74 5435 17 is be VBZ cord-015021-pol2qm74 5435 18 a a DT cord-015021-pol2qm74 5435 19 very very RB cord-015021-pol2qm74 5435 20 stable stable JJ cord-015021-pol2qm74 5435 21 molecule molecule NN cord-015021-pol2qm74 5435 22 . . . cord-015021-pol2qm74 5436 1 The the DT cord-015021-pol2qm74 5436 2 half half JJ cord-015021-pol2qm74 5436 3 Iife Iife NNP cord-015021-pol2qm74 5436 4 of of IN cord-015021-pol2qm74 5436 5 ProCT ProCT NNP cord-015021-pol2qm74 5436 6 in in IN cord-015021-pol2qm74 5437 1 ~he ~he NNP cord-015021-pol2qm74 5438 1 blood blood NN cord-015021-pol2qm74 5438 2 is be VBZ cord-015021-pol2qm74 5438 3 surprising surprising JJ cord-015021-pol2qm74 5438 4 if if IN cord-015021-pol2qm74 5438 5 we -PRON- PRP cord-015021-pol2qm74 5438 6 consider consider VBP cord-015021-pol2qm74 5438 7 the the DT cord-015021-pol2qm74 5438 8 half half JJ cord-015021-pol2qm74 5438 9 llfe llfe NN cord-015021-pol2qm74 5438 10 ( ( -LRB- cord-015021-pol2qm74 5438 11 about about RB cord-015021-pol2qm74 5438 12 nine nine CD cord-015021-pol2qm74 5438 13 mirtute mirtute NN cord-015021-pol2qm74 5438 14 ) ) -RRB- cord-015021-pol2qm74 5438 15 of of IN cord-015021-pol2qm74 5438 16 mature mature JJ cord-015021-pol2qm74 5438 17 ¢alcitonin ¢alcitonin JJ cord-015021-pol2qm74 5439 1 ( ( -LRB- cord-015021-pol2qm74 5439 2 CO CO NNP cord-015021-pol2qm74 5439 3 . . . cord-015021-pol2qm74 5440 1 We -PRON- PRP cord-015021-pol2qm74 5440 2 have have VBP cord-015021-pol2qm74 5440 3 found find VBN cord-015021-pol2qm74 5440 4 that that IN cord-015021-pol2qm74 5440 5 it -PRON- PRP cord-015021-pol2qm74 5440 6 is be VBZ cord-015021-pol2qm74 5440 7 due due JJ cord-015021-pol2qm74 5440 8 to to IN cord-015021-pol2qm74 5440 9 the the DT cord-015021-pol2qm74 5440 10 binding binding NN cord-015021-pol2qm74 5440 11 of of IN cord-015021-pol2qm74 5440 12 ProCT ProCT NNP cord-015021-pol2qm74 5440 13 with with IN cord-015021-pol2qm74 5440 14 a a DT cord-015021-pol2qm74 5440 15 protein protein NN cord-015021-pol2qm74 5440 16 on on IN cord-015021-pol2qm74 5440 17 the the DT cord-015021-pol2qm74 5440 18 N N NNP cord-015021-pol2qm74 5440 19 - - HYPH cord-015021-pol2qm74 5440 20 termktal termktal NNP cord-015021-pol2qm74 5440 21 part part NN cord-015021-pol2qm74 5440 22 . . . cord-015021-pol2qm74 5441 1 Thin thin JJ cord-015021-pol2qm74 5441 2 complex complex NN cord-015021-pol2qm74 5441 3 of of IN cord-015021-pol2qm74 5441 4 about about RB cord-015021-pol2qm74 5441 5 80 80 CD cord-015021-pol2qm74 5441 6 000 000 CD cord-015021-pol2qm74 5441 7 daltons dalton NNS cord-015021-pol2qm74 5441 8 is be VBZ cord-015021-pol2qm74 5441 9 unable unable JJ cord-015021-pol2qm74 5441 10 to to TO cord-015021-pol2qm74 5441 11 cross cross VB cord-015021-pol2qm74 5441 12 the the DT cord-015021-pol2qm74 5441 13 kidney kidney NN cord-015021-pol2qm74 5441 14 and and CC cord-015021-pol2qm74 5441 15 the the DT cord-015021-pol2qm74 5441 16 C_N9 C_N9 NNP cord-015021-pol2qm74 5441 17 barriers barrier NNS cord-015021-pol2qm74 5441 18 and and CC cord-015021-pol2qm74 5441 19 the the DT cord-015021-pol2qm74 5441 20 half half JJ cord-015021-pol2qm74 5441 21 life life NN cord-015021-pol2qm74 5441 22 is be VBZ cord-015021-pol2qm74 5441 23 at at IN cord-015021-pol2qm74 5441 24 least least JJS cord-015021-pol2qm74 5441 25 elghteen elghteen NNP cord-015021-pol2qm74 5441 26 hours hour NNS cord-015021-pol2qm74 5441 27 . . . cord-015021-pol2qm74 5442 1 This this DT cord-015021-pol2qm74 5443 1 long long JJ cord-015021-pol2qm74 5443 2 half half NNP cord-015021-pol2qm74 5443 3 llfe llfe NNP cord-015021-pol2qm74 5443 4 is be VBZ cord-015021-pol2qm74 5443 5 very very RB cord-015021-pol2qm74 5443 6 useful useful JJ cord-015021-pol2qm74 5443 7 in in IN cord-015021-pol2qm74 5443 8 the the DT cord-015021-pol2qm74 5443 9 evaluation evaluation NN cord-015021-pol2qm74 5443 10 of of IN cord-015021-pol2qm74 5443 11 a a DT cord-015021-pol2qm74 5443 12 sepsis sepsis NN cord-015021-pol2qm74 5443 13 . . . cord-015021-pol2qm74 5444 1 A a DT cord-015021-pol2qm74 5444 2 very very RB cord-015021-pol2qm74 5444 3 sensitive sensitive JJ cord-015021-pol2qm74 5444 4 and and CC cord-015021-pol2qm74 5444 5 specific specific JJ cord-015021-pol2qm74 5444 6 sandwich sandwich NN cord-015021-pol2qm74 5444 7 in'ununoassay in'ununoassay NNP cord-015021-pol2qm74 5444 8 has have VBZ cord-015021-pol2qm74 5444 9 been be VBN cord-015021-pol2qm74 5444 10 developped developpe VBN cord-015021-pol2qm74 5444 11 . . . cord-015021-pol2qm74 5445 1 The the DT cord-015021-pol2qm74 5445 2 results result NNS cord-015021-pol2qm74 5445 3 cart cart NN cord-015021-pol2qm74 5445 4 be be VB cord-015021-pol2qm74 5445 5 delivered deliver VBN cord-015021-pol2qm74 5445 6 in in IN cord-015021-pol2qm74 5445 7 tWO two CD cord-015021-pol2qm74 5445 8 hours hour NNS cord-015021-pol2qm74 5445 9 . . . cord-015021-pol2qm74 5446 1 At at IN cord-015021-pol2qm74 5446 2 time time NN cord-015021-pol2qm74 5446 3 , , , cord-015021-pol2qm74 5446 4 we -PRON- PRP cord-015021-pol2qm74 5446 5 know know VBP cord-015021-pol2qm74 5446 6 that that IN cord-015021-pol2qm74 5446 7 in in IN cord-015021-pol2qm74 5446 8 the the DT cord-015021-pol2qm74 5446 9 healthy healthy JJ cord-015021-pol2qm74 5446 10 adults adult NNS cord-015021-pol2qm74 5446 11 , , , cord-015021-pol2qm74 5446 12 the the DT cord-015021-pol2qm74 5446 13 values value NNS cord-015021-pol2qm74 5446 14 are be VBP cord-015021-pol2qm74 5446 15 less less JJR cord-015021-pol2qm74 5446 16 thau thau NNP cord-015021-pol2qm74 5446 17 0.1ng 0.1ng NNP cord-015021-pol2qm74 5446 18 / / SYM cord-015021-pol2qm74 5446 19 ml ml NN cord-015021-pol2qm74 5446 20 . . . cord-015021-pol2qm74 5447 1 It -PRON- PRP cord-015021-pol2qm74 5447 2 is be VBZ cord-015021-pol2qm74 5447 3 also also RB cord-015021-pol2qm74 5447 4 clear clear JJ cord-015021-pol2qm74 5447 5 that that IN cord-015021-pol2qm74 5447 6 ProCT ProCT NNP cord-015021-pol2qm74 5447 7 is be VBZ cord-015021-pol2qm74 5447 8 not not RB cord-015021-pol2qm74 5447 9 increased increase VBN cord-015021-pol2qm74 5448 1 ~n ~n NNP cord-015021-pol2qm74 5448 2 patients patient NNS cord-015021-pol2qm74 5448 3 wlth wlth VBP cord-015021-pol2qm74 5448 4 inflammatory inflammatory JJ cord-015021-pol2qm74 5448 5 dleeasea dleeasea NNP cord-015021-pol2qm74 5448 6 without without IN cord-015021-pol2qm74 5448 7 lnfectlon lnfectlon NNP cord-015021-pol2qm74 5448 8 . . . cord-015021-pol2qm74 5449 1 For for IN cord-015021-pol2qm74 5449 2 instance instance NN cord-015021-pol2qm74 5449 3 , , , cord-015021-pol2qm74 5449 4 ProCT ProCT NNP cord-015021-pol2qm74 5449 5 is be VBZ cord-015021-pol2qm74 5449 6 not not RB cord-015021-pol2qm74 5449 7 signLffcat3vely signLffcat3vely NNP cord-015021-pol2qm74 5449 8 increased increase VBN cord-015021-pol2qm74 5449 9 in in IN cord-015021-pol2qm74 5449 10 purpura purpura NNP cord-015021-pol2qm74 5449 11 rhumatoM rhumatoM NNP cord-015021-pol2qm74 5449 12 , , , cord-015021-pol2qm74 5449 13 arthritis arthritis NN cord-015021-pol2qm74 5449 14 , , , cord-015021-pol2qm74 5449 15 Crohn Crohn NNP cord-015021-pol2qm74 5449 16 's 's POS cord-015021-pol2qm74 5449 17 disease disease NN cord-015021-pol2qm74 5449 18 , , , cord-015021-pol2qm74 5449 19 rectocolitis rectocolitis NNP cord-015021-pol2qm74 5449 20 , , , cord-015021-pol2qm74 5449 21 also also RB cord-015021-pol2qm74 5449 22 in in IN cord-015021-pol2qm74 5449 23 various various JJ cord-015021-pol2qm74 5449 24 cancer cancer NN cord-015021-pol2qm74 5449 25 patients patient NNS cord-015021-pol2qm74 5449 26 with with IN cord-015021-pol2qm74 5449 27 inflammatory inflammatory JJ cord-015021-pol2qm74 5449 28 components component NNS cord-015021-pol2qm74 5449 29 . . . cord-015021-pol2qm74 5450 1 Am be VBP cord-015021-pol2qm74 5450 2 other other JJ cord-015021-pol2qm74 5450 3 interesting interesting JJ cord-015021-pol2qm74 5450 4 finding finding NN cord-015021-pol2qm74 5450 5 , , , cord-015021-pol2qm74 5450 6 is be VBZ cord-015021-pol2qm74 5450 7 the the DT cord-015021-pol2qm74 5450 8 absence absence NN cord-015021-pol2qm74 5450 9 of of IN cord-015021-pol2qm74 5450 10 increase increase NN cord-015021-pol2qm74 5450 11 or or CC cord-015021-pol2qm74 5450 12 a a DT cord-015021-pol2qm74 5450 13 very very RB cord-015021-pol2qm74 5450 14 low low JJ cord-015021-pol2qm74 5450 15 increase increase NN cord-015021-pol2qm74 5450 16 in in IN cord-015021-pol2qm74 5450 17 the the DT cord-015021-pol2qm74 5450 18 viral viral JJ cord-015021-pol2qm74 5450 19 infections infection NNS cord-015021-pol2qm74 5450 20 . . . cord-015021-pol2qm74 5451 1 At at IN cord-015021-pol2qm74 5451 2 the the DT cord-015021-pol2qm74 5451 3 opp0site opp0site NNP cord-015021-pol2qm74 5451 4 , , , cord-015021-pol2qm74 5451 5 in in IN cord-015021-pol2qm74 5451 6 all all PDT cord-015021-pol2qm74 5451 7 the the DT cord-015021-pol2qm74 5451 8 patients patient NNS cord-015021-pol2qm74 5451 9 with with IN cord-015021-pol2qm74 5451 10 bacterial bacterial JJ cord-015021-pol2qm74 5451 11 sepsis sepsis NN cord-015021-pol2qm74 5451 12 or or CC cord-015021-pol2qm74 5451 13 in in IN cord-015021-pol2qm74 5451 14 the the DT cord-015021-pol2qm74 5451 15 malaria malaria NNP cord-015021-pol2qm74 5451 16 pat pat NNP cord-015021-pol2qm74 5451 17 / / SYM cord-015021-pol2qm74 5451 18 ants ant NNS cord-015021-pol2qm74 5451 19 , , , cord-015021-pol2qm74 5451 20 ProGT ProGT NNP cord-015021-pol2qm74 5451 21 was be VBD cord-015021-pol2qm74 5451 22 dramatically dramatically RB cord-015021-pol2qm74 5451 23 increased increase VBN cord-015021-pol2qm74 5451 24 , , , cord-015021-pol2qm74 5451 25 from from IN cord-015021-pol2qm74 5451 26 I00 I00 NNP cord-015021-pol2qm74 5451 27 to to IN cord-015021-pol2qm74 5451 28 10 10 CD cord-015021-pol2qm74 5451 29 000 000 CD cord-015021-pol2qm74 5451 30 fold fold NN cord-015021-pol2qm74 5451 31 . . . cord-015021-pol2qm74 5452 1 P p NN cord-015021-pol2qm74 5452 2 ~ ~ CD cord-015021-pol2qm74 5452 3 oCT oct PRP cord-015021-pol2qm74 5452 4 can can MD cord-015021-pol2qm74 5452 5 be be VB cord-015021-pol2qm74 5452 6 useful useful JJ cord-015021-pol2qm74 5452 7 to to IN cord-015021-pol2qm74 5452 8 the the DT cord-015021-pol2qm74 5452 9 follow follow NN cord-015021-pol2qm74 5452 10 up up IN cord-015021-pol2qm74 5452 11 of of IN cord-015021-pol2qm74 5452 12 patients patient NNS cord-015021-pol2qm74 5452 13 with with IN cord-015021-pol2qm74 5452 14 sepsis sepsis NN cord-015021-pol2qm74 5452 15 . . . cord-015021-pol2qm74 5453 1 Actually actually RB cord-015021-pol2qm74 5453 2 , , , cord-015021-pol2qm74 5453 3 we -PRON- PRP cord-015021-pol2qm74 5453 4 do do VBP cord-015021-pol2qm74 5453 5 n't not RB cord-015021-pol2qm74 5453 6 know know VB cord-015021-pol2qm74 5453 7 the the DT cord-015021-pol2qm74 5453 8 origin origin NN cord-015021-pol2qm74 5453 9 of of IN cord-015021-pol2qm74 5453 10 this this DT cord-015021-pol2qm74 5453 11 ProCT ProCT NNP cord-015021-pol2qm74 5453 12 production production NN cord-015021-pol2qm74 5453 13 , , , cord-015021-pol2qm74 5453 14 in in IN cord-015021-pol2qm74 5453 15 the the DT cord-015021-pol2qm74 5453 16 United United NNP cord-015021-pol2qm74 5453 17 States States NNP cord-015021-pol2qm74 5453 18 , , , cord-015021-pol2qm74 5453 19 will will MD cord-015021-pol2qm74 5453 20 also also RB cord-015021-pol2qm74 5453 21 be be VB cord-015021-pol2qm74 5453 22 discussed discuss VBN cord-015021-pol2qm74 5453 23 . . . cord-015021-pol2qm74 5454 1 The the DT cord-015021-pol2qm74 5454 2 SepTest SepTest NNP cord-015021-pol2qm74 5454 3 portion portion NN cord-015021-pol2qm74 5454 4 of of IN cord-015021-pol2qm74 5454 5 this this DT cord-015021-pol2qm74 5454 6 study study NN cord-015021-pol2qm74 5454 7 will will MD cord-015021-pol2qm74 5454 8 eventually eventually RB cord-015021-pol2qm74 5454 9 enroll enroll VB cord-015021-pol2qm74 5454 10 over over IN cord-015021-pol2qm74 5454 11 500 500 CD cord-015021-pol2qm74 5454 12 patients patient NNS cord-015021-pol2qm74 5454 13 tentatively tentatively RB cord-015021-pol2qm74 5454 14 diagnosed diagnose VBN cord-015021-pol2qm74 5454 15 as as IN cord-015021-pol2qm74 5454 16 septic septic NN cord-015021-pol2qm74 5454 17 . . . cord-015021-pol2qm74 5455 1 The the DT cord-015021-pol2qm74 5455 2 results result NNS cord-015021-pol2qm74 5455 3 of of IN cord-015021-pol2qm74 5455 4 SepTest SepTest NNP cord-015021-pol2qm74 5455 5 will will MD cord-015021-pol2qm74 5455 6 be be VB cord-015021-pol2qm74 5455 7 compared compare VBN cord-015021-pol2qm74 5455 8 with with IN cord-015021-pol2qm74 5455 9 commonly commonly RB cord-015021-pol2qm74 5455 10 accepted accept VBN cord-015021-pol2qm74 5455 11 symptoms symptom NNS cord-015021-pol2qm74 5455 12 and and CC cord-015021-pol2qm74 5455 13 criteria criterion NNS cord-015021-pol2qm74 5455 14 associated associate VBN cord-015021-pol2qm74 5455 15 with with IN cord-015021-pol2qm74 5455 16 sepsis sepsis NN cord-015021-pol2qm74 5455 17 in in IN cord-015021-pol2qm74 5455 18 order order NN cord-015021-pol2qm74 5455 19 to to TO cord-015021-pol2qm74 5455 20 determine determine VB cord-015021-pol2qm74 5455 21 the the DT cord-015021-pol2qm74 5455 22 clinical clinical JJ cord-015021-pol2qm74 5455 23 utility utility NN cord-015021-pol2qm74 5455 24 of of IN cord-015021-pol2qm74 5455 25 this this DT cord-015021-pol2qm74 5455 26 endotoxin endotoxin NN cord-015021-pol2qm74 5455 27 assay assay NN cord-015021-pol2qm74 5455 28 . . . cord-015021-pol2qm74 5456 1 Preclinical preclinical JJ cord-015021-pol2qm74 5456 2 results result NNS cord-015021-pol2qm74 5456 3 of of IN cord-015021-pol2qm74 5456 4 patients patient NNS cord-015021-pol2qm74 5456 5 and and CC cord-015021-pol2qm74 5456 6 normals normal NNS cord-015021-pol2qm74 5456 7 be be VB cord-015021-pol2qm74 5456 8 presented present VBN cord-015021-pol2qm74 5456 9 as as RB cord-015021-pol2qm74 5456 10 well well RB cord-015021-pol2qm74 5456 11 as as IN cord-015021-pol2qm74 5456 12 data datum NNS cord-015021-pol2qm74 5456 13 on on IN cord-015021-pol2qm74 5456 14 the the DT cord-015021-pol2qm74 5456 15 time time NN cord-015021-pol2qm74 5456 16 course course NN cord-015021-pol2qm74 5456 17 of of IN cord-015021-pol2qm74 5456 18 endotoxemia endotoxemia NN cord-015021-pol2qm74 5456 19 and and CC cord-015021-pol2qm74 5456 20 clinical clinical JJ cord-015021-pol2qm74 5456 21 outcome outcome NN cord-015021-pol2qm74 5456 22 of of IN cord-015021-pol2qm74 5456 23 selected select VBN cord-015021-pol2qm74 5456 24 septic septic JJ cord-015021-pol2qm74 5456 25 patients patient NNS cord-015021-pol2qm74 5456 26 . . . cord-015021-pol2qm74 5457 1 Preparation preparation NN cord-015021-pol2qm74 5457 2 of of IN cord-015021-pol2qm74 5457 3 DNA DNA NNP cord-015021-pol2qm74 5457 4 Libraries Libraries NNPS cord-015021-pol2qm74 5457 5 Clifford Clifford NNP cord-015021-pol2qm74 5457 6 W. W. NNP cord-015021-pol2qm74 5457 7 Schweinfest Schweinfest NNP cord-015021-pol2qm74 5457 8 , , , cord-015021-pol2qm74 5457 9 Ph.D. Ph.D. NNP cord-015021-pol2qm74 5457 10 A a DT cord-015021-pol2qm74 5457 11 fundamental fundamental JJ cord-015021-pol2qm74 5457 12 tool tool NN cord-015021-pol2qm74 5457 13 of of IN cord-015021-pol2qm74 5457 14 the the DT cord-015021-pol2qm74 5457 15 molecular molecular JJ cord-015021-pol2qm74 5457 16 biologist biologist NN cord-015021-pol2qm74 5457 17 today today NN cord-015021-pol2qm74 5457 18 is be VBZ cord-015021-pol2qm74 5457 19 the the DT cord-015021-pol2qm74 5457 20 ability ability NN cord-015021-pol2qm74 5457 21 to to TO cord-015021-pol2qm74 5457 22 work work VB cord-015021-pol2qm74 5457 23 with with IN cord-015021-pol2qm74 5457 24 purified purify VBN cord-015021-pol2qm74 5457 25 DNAs dna NNS cord-015021-pol2qm74 5457 26 representing represent VBG cord-015021-pol2qm74 5457 27 genes gene NNS cord-015021-pol2qm74 5457 28 of of IN cord-015021-pol2qm74 5457 29 interest interest NN cord-015021-pol2qm74 5457 30 with with IN cord-015021-pol2qm74 5457 31 respect respect NN cord-015021-pol2qm74 5457 32 to to IN cord-015021-pol2qm74 5457 33 the the DT cord-015021-pol2qm74 5457 34 investigator investigator NN cord-015021-pol2qm74 5457 35 's 's POS cord-015021-pol2qm74 5457 36 field field NN cord-015021-pol2qm74 5457 37 of of IN cord-015021-pol2qm74 5457 38 study study NN cord-015021-pol2qm74 5457 39 . . . cord-015021-pol2qm74 5458 1 Originally originally RB cord-015021-pol2qm74 5458 2 applied apply VBD cord-015021-pol2qm74 5458 3 almost almost RB cord-015021-pol2qm74 5458 4 20 20 CD cord-015021-pol2qm74 5458 5 years year NNS cord-015021-pol2qm74 5458 6 ago ago RB cord-015021-pol2qm74 5458 7 to to IN cord-015021-pol2qm74 5458 8 the the DT cord-015021-pol2qm74 5458 9 genetic genetic JJ cord-015021-pol2qm74 5458 10 dissection dissection NN cord-015021-pol2qm74 5458 11 of of IN cord-015021-pol2qm74 5458 12 simple simple JJ cord-015021-pol2qm74 5458 13 organisms organism NNS cord-015021-pol2qm74 5458 14 such such JJ cord-015021-pol2qm74 5458 15 as as IN cord-015021-pol2qm74 5458 16 viruses virus NNS cord-015021-pol2qm74 5458 17 and and CC cord-015021-pol2qm74 5458 18 bacteria bacteria NNS cord-015021-pol2qm74 5458 19 , , , cord-015021-pol2qm74 5458 20 molecfllar molecfllar NN cord-015021-pol2qm74 5458 21 cloning cloning NN cord-015021-pol2qm74 5458 22 was be VBD cord-015021-pol2qm74 5458 23 rapidly rapidly RB cord-015021-pol2qm74 5458 24 applied apply VBN cord-015021-pol2qm74 5458 25 to to TO cord-015021-pol2qm74 5458 26 study study VB cord-015021-pol2qm74 5458 27 the the DT cord-015021-pol2qm74 5458 28 more more RBR cord-015021-pol2qm74 5458 29 complex complex JJ cord-015021-pol2qm74 5458 30 genetics genetic NNS cord-015021-pol2qm74 5458 31 of of IN cord-015021-pol2qm74 5458 32 the the DT cord-015021-pol2qm74 5458 33 mammalian mammalian JJ cord-015021-pol2qm74 5458 34 cell cell NN cord-015021-pol2qm74 5458 35 . . . cord-015021-pol2qm74 5459 1 Today today NN cord-015021-pol2qm74 5459 2 , , , cord-015021-pol2qm74 5459 3 virtually virtually RB cord-015021-pol2qm74 5459 4 any any DT cord-015021-pol2qm74 5459 5 study study NN cord-015021-pol2qm74 5459 6 of of IN cord-015021-pol2qm74 5459 7 cell cell NN cord-015021-pol2qm74 5459 8 physiology physiology NN cord-015021-pol2qm74 5459 9 which which WDT cord-015021-pol2qm74 5459 10 depends depend VBZ cord-015021-pol2qm74 5459 11 upon upon IN cord-015021-pol2qm74 5459 12 specific specific JJ cord-015021-pol2qm74 5459 13 gene gene NN cord-015021-pol2qm74 5459 14 expression expression NN cord-015021-pol2qm74 5459 15 is be VBZ cord-015021-pol2qm74 5459 16 approachable approachable JJ cord-015021-pol2qm74 5459 17 using use VBG cord-015021-pol2qm74 5459 18 the the DT cord-015021-pol2qm74 5459 19 tools tool NNS cord-015021-pol2qm74 5459 20 of of IN cord-015021-pol2qm74 5459 21 the the DT cord-015021-pol2qm74 5459 22 molecular molecular JJ cord-015021-pol2qm74 5459 23 biologist biologist NN cord-015021-pol2qm74 5459 24 . . . cord-015021-pol2qm74 5460 1 Therefore therefore RB cord-015021-pol2qm74 5460 2 , , , cord-015021-pol2qm74 5460 3 stress stress NN cord-015021-pol2qm74 5460 4 induced induce VBN cord-015021-pol2qm74 5460 5 gene gene NN cord-015021-pol2qm74 5460 6 expression expression NN cord-015021-pol2qm74 5460 7 ( ( -LRB- cord-015021-pol2qm74 5460 8 such such JJ cord-015021-pol2qm74 5460 9 as as IN cord-015021-pol2qm74 5460 10 the the DT cord-015021-pol2qm74 5460 11 heat heat NN cord-015021-pol2qm74 5460 12 shock shock NN cord-015021-pol2qm74 5460 13 gene gene NN cord-015021-pol2qm74 5460 14 , , , cord-015021-pol2qm74 5460 15 hsp70 hsp70 ADD cord-015021-pol2qm74 5460 16 ) ) -RRB- cord-015021-pol2qm74 5460 17 or or CC cord-015021-pol2qm74 5460 18 the the DT cord-015021-pol2qm74 5460 19 regulation regulation NN cord-015021-pol2qm74 5460 20 of of IN cord-015021-pol2qm74 5460 21 the the DT cord-015021-pol2qm74 5460 22 nitric nitric NN cord-015021-pol2qm74 5460 23 oxide oxide NN cord-015021-pol2qm74 5460 24 synthetase synthetase NN cord-015021-pol2qm74 5460 25 gene gene NN cord-015021-pol2qm74 5460 26 or or CC cord-015021-pol2qm74 5460 27 the the DT cord-015021-pol2qm74 5460 28 induction induction NN cord-015021-pol2qm74 5460 29 of of IN cord-015021-pol2qm74 5460 30 cytokines cytokine NNS cord-015021-pol2qm74 5460 31 and and CC cord-015021-pol2qm74 5460 32 growth growth NN cord-015021-pol2qm74 5460 33 factors factor NNS cord-015021-pol2qm74 5460 34 as as IN cord-015021-pol2qm74 5460 35 a a DT cord-015021-pol2qm74 5460 36 result result NN cord-015021-pol2qm74 5460 37 of of IN cord-015021-pol2qm74 5460 38 trauma trauma NN cord-015021-pol2qm74 5460 39 or or CC cord-015021-pol2qm74 5460 40 injury injury NN cord-015021-pol2qm74 5460 41 lend lend VBP cord-015021-pol2qm74 5460 42 themselves -PRON- PRP cord-015021-pol2qm74 5460 43 to to IN cord-015021-pol2qm74 5460 44 investigation investigation NN cord-015021-pol2qm74 5460 45 at at IN cord-015021-pol2qm74 5460 46 the the DT cord-015021-pol2qm74 5460 47 level level NN cord-015021-pol2qm74 5460 48 of of IN cord-015021-pol2qm74 5460 49 the the DT cord-015021-pol2qm74 5460 50 gene gene NN cord-015021-pol2qm74 5460 51 . . . cord-015021-pol2qm74 5461 1 During during IN cord-015021-pol2qm74 5461 2 these these DT cord-015021-pol2qm74 5461 3 workshops workshop NNS cord-015021-pol2qm74 5461 4 , , , cord-015021-pol2qm74 5461 5 we -PRON- PRP cord-015021-pol2qm74 5461 6 will will MD cord-015021-pol2qm74 5461 7 discuss discuss VB cord-015021-pol2qm74 5461 8 the the DT cord-015021-pol2qm74 5461 9 means mean NNS cord-015021-pol2qm74 5461 10 by by IN cord-015021-pol2qm74 5461 11 which which WDT cord-015021-pol2qm74 5461 12 cDNAs cdna NNS cord-015021-pol2qm74 5461 13 and and CC cord-015021-pol2qm74 5461 14 genes gene NNS cord-015021-pol2qm74 5461 15 are be VBP cord-015021-pol2qm74 5461 16 isolated isolate VBN cord-015021-pol2qm74 5461 17 , , , cord-015021-pol2qm74 5461 18 amplified amplify VBN cord-015021-pol2qm74 5461 19 and and CC cord-015021-pol2qm74 5461 20 identified identify VBN cord-015021-pol2qm74 5461 21 . . . cord-015021-pol2qm74 5462 1 We -PRON- PRP cord-015021-pol2qm74 5462 2 will will MD cord-015021-pol2qm74 5462 3 discuss discuss VB cord-015021-pol2qm74 5462 4 the the DT cord-015021-pol2qm74 5462 5 strategies strategy NNS cord-015021-pol2qm74 5462 6 and and CC cord-015021-pol2qm74 5462 7 methods method NNS cord-015021-pol2qm74 5462 8 for for IN cord-015021-pol2qm74 5462 9 cloning clone VBG cord-015021-pol2qm74 5462 10 cDNAs cdna NNS cord-015021-pol2qm74 5462 11 and and CC cord-015021-pol2qm74 5462 12 genomic genomic JJ cord-015021-pol2qm74 5462 13 DNAs dna NNS cord-015021-pol2qm74 5462 14 , , , cord-015021-pol2qm74 5462 15 for for IN cord-015021-pol2qm74 5462 16 organizing organize VBG cord-015021-pol2qm74 5462 17 such such JJ cord-015021-pol2qm74 5462 18 cloned clone VBN cord-015021-pol2qm74 5462 19 libraries library NNS cord-015021-pol2qm74 5462 20 , , , cord-015021-pol2qm74 5462 21 for for IN cord-015021-pol2qm74 5462 22 finding find VBG cord-015021-pol2qm74 5462 23 specific specific JJ cord-015021-pol2qm74 5462 24 genes gene NNS cord-015021-pol2qm74 5462 25 and and CC cord-015021-pol2qm74 5462 26 for for IN cord-015021-pol2qm74 5462 27 characterizing characterize VBG cord-015021-pol2qm74 5462 28 those those DT cord-015021-pol2qm74 5462 29 genes gene NNS cord-015021-pol2qm74 5462 30 . . . cord-015021-pol2qm74 5463 1 This this DT cord-015021-pol2qm74 5463 2 speaker speaker NN cord-015021-pol2qm74 5463 3 will will MD cord-015021-pol2qm74 5463 4 focus focus VB cord-015021-pol2qm74 5463 5 on on IN cord-015021-pol2qm74 5463 6 the the DT cord-015021-pol2qm74 5463 7 techniques technique NNS cord-015021-pol2qm74 5463 8 and and CC cord-015021-pol2qm74 5463 9 considerations consideration NNS cord-015021-pol2qm74 5463 10 involved involve VBN cord-015021-pol2qm74 5463 11 in in IN cord-015021-pol2qm74 5463 12 the the DT cord-015021-pol2qm74 5463 13 synthesis synthesis NN cord-015021-pol2qm74 5463 14 of of IN cord-015021-pol2qm74 5463 15 cDNA cDNA NNP cord-015021-pol2qm74 5463 16 libraries library NNS cord-015021-pol2qm74 5463 17 . . . cord-015021-pol2qm74 5464 1 Topics topic NNS cord-015021-pol2qm74 5464 2 include include VBP cord-015021-pol2qm74 5464 3 RNA RNA NNP cord-015021-pol2qm74 5464 4 isolation isolation NN cord-015021-pol2qm74 5464 5 , , , cord-015021-pol2qm74 5464 6 mRNA mrna NN cord-015021-pol2qm74 5464 7 quality quality NN cord-015021-pol2qm74 5464 8 , , , cord-015021-pol2qm74 5464 9 reverse reverse VB cord-015021-pol2qm74 5464 10 transcription transcription NN cord-015021-pol2qm74 5464 11 , , , cord-015021-pol2qm74 5464 12 choice choice NN cord-015021-pol2qm74 5464 13 of of IN cord-015021-pol2qm74 5464 14 cloning clone VBG cord-015021-pol2qm74 5464 15 vectors vector NNS cord-015021-pol2qm74 5464 16 and and CC cord-015021-pol2qm74 5464 17 library library NN cord-015021-pol2qm74 5464 18 quality quality NN cord-015021-pol2qm74 5464 19 . . . cord-015021-pol2qm74 5465 1 Genomic genomic JJ cord-015021-pol2qm74 5465 2 DNA dna NN cord-015021-pol2qm74 5465 3 library library NN cord-015021-pol2qm74 5465 4 synthesis synthesis NN cord-015021-pol2qm74 5465 5 will will MD cord-015021-pol2qm74 5465 6 also also RB cord-015021-pol2qm74 5465 7 be be VB cord-015021-pol2qm74 5465 8 discussed discuss VBN cord-015021-pol2qm74 5465 9 with with IN cord-015021-pol2qm74 5465 10 respect respect NN cord-015021-pol2qm74 5465 11 to to IN cord-015021-pol2qm74 5465 12 the the DT cord-015021-pol2qm74 5465 13 vector vector NN cord-015021-pol2qm74 5465 14 / / SYM cord-015021-pol2qm74 5465 15 host host NN cord-015021-pol2qm74 5465 16 systems system NNS cord-015021-pol2qm74 5465 17 available available JJ cord-015021-pol2qm74 5465 18 and and CC cord-015021-pol2qm74 5465 19 applications application NNS cord-015021-pol2qm74 5465 20 which which WDT cord-015021-pol2qm74 5465 21 are be VBP cord-015021-pol2qm74 5465 22 specific specific JJ cord-015021-pol2qm74 5465 23 to to IN cord-015021-pol2qm74 5465 24 genomic genomic JJ cord-015021-pol2qm74 5465 25 DNA dna NN cord-015021-pol2qm74 5465 26 . . . cord-015021-pol2qm74 5466 1 Finally finally RB cord-015021-pol2qm74 5466 2 , , , cord-015021-pol2qm74 5466 3 polymerase polymerase NN cord-015021-pol2qm74 5466 4 chain chain NN cord-015021-pol2qm74 5466 5 reaction reaction NN cord-015021-pol2qm74 5466 6 ( ( -LRB- cord-015021-pol2qm74 5466 7 PCR PCR NNP cord-015021-pol2qm74 5466 8 ) ) -RRB- cord-015021-pol2qm74 5466 9 will will MD cord-015021-pol2qm74 5466 10 be be VB cord-015021-pol2qm74 5466 11 discussed discuss VBN cord-015021-pol2qm74 5466 12 briefly briefly RB cord-015021-pol2qm74 5466 13 with with IN cord-015021-pol2qm74 5466 14 regard regard NN cord-015021-pol2qm74 5466 15 to to IN cord-015021-pol2qm74 5466 16 its -PRON- PRP$ cord-015021-pol2qm74 5466 17 impact impact NN cord-015021-pol2qm74 5466 18 on on IN cord-015021-pol2qm74 5466 19 DNA dna NN cord-015021-pol2qm74 5466 20 cloning cloning NN cord-015021-pol2qm74 5466 21 . . . cord-015021-pol2qm74 5467 1 The the DT cord-015021-pol2qm74 5467 2 identification identification NN cord-015021-pol2qm74 5467 3 of of IN cord-015021-pol2qm74 5467 4 the the DT cord-015021-pol2qm74 5467 5 genes gene NNS cord-015021-pol2qm74 5467 6 or or CC cord-015021-pol2qm74 5467 7 gene gene NN cord-015021-pol2qm74 5467 8 products product NNS cord-015021-pol2qm74 5467 9 that that WDT cord-015021-pol2qm74 5467 10 have have VBP cord-015021-pol2qm74 5467 11 a a DT cord-015021-pol2qm74 5467 12 role role NN cord-015021-pol2qm74 5467 13 in in IN cord-015021-pol2qm74 5467 14 cellular cellular JJ cord-015021-pol2qm74 5467 15 processes process NNS cord-015021-pol2qm74 5467 16 is be VBZ cord-015021-pol2qm74 5467 17 fundamental fundamental JJ cord-015021-pol2qm74 5467 18 to to IN cord-015021-pol2qm74 5467 19 our -PRON- PRP$ cord-015021-pol2qm74 5467 20 understanding understanding NN cord-015021-pol2qm74 5467 21 of of IN cord-015021-pol2qm74 5467 22 genetic genetic JJ cord-015021-pol2qm74 5467 23 control control NN cord-015021-pol2qm74 5467 24 and and CC cord-015021-pol2qm74 5467 25 methodologies methodology NNS cord-015021-pol2qm74 5467 26 to to TO cord-015021-pol2qm74 5467 27 achieve achieve VB cord-015021-pol2qm74 5467 28 this this DT cord-015021-pol2qm74 5467 29 aim aim NN cord-015021-pol2qm74 5467 30 are be VBP cord-015021-pol2qm74 5467 31 currently currently RB cord-015021-pol2qm74 5467 32 available available JJ cord-015021-pol2qm74 5467 33 . . . cord-015021-pol2qm74 5468 1 All all DT cord-015021-pol2qm74 5468 2 levels level NNS cord-015021-pol2qm74 5468 3 of of IN cord-015021-pol2qm74 5468 4 the the DT cord-015021-pol2qm74 5468 5 various various JJ cord-015021-pol2qm74 5468 6 signal signal NN cord-015021-pol2qm74 5468 7 transduction transduction NN cord-015021-pol2qm74 5468 8 pathways pathway NNS cord-015021-pol2qm74 5468 9 can can MD cord-015021-pol2qm74 5468 10 b~ b~ VB cord-015021-pol2qm74 5468 11 molecularly molecularly RB cord-015021-pol2qm74 5468 12 analyzed analyze VBN cord-015021-pol2qm74 5468 13 to to TO cord-015021-pol2qm74 5468 14 define define VB cord-015021-pol2qm74 5468 15 the the DT cord-015021-pol2qm74 5468 16 mechanism mechanism NN cord-015021-pol2qm74 5468 17 by by IN cord-015021-pol2qm74 5468 18 which which WDT cord-015021-pol2qm74 5468 19 critical critical JJ cord-015021-pol2qm74 5468 20 steps step NNS cord-015021-pol2qm74 5468 21 in in IN cord-015021-pol2qm74 5468 22 each each DT cord-015021-pol2qm74 5468 23 pathway pathway NN cord-015021-pol2qm74 5468 24 are be VBP cord-015021-pol2qm74 5468 25 achieved achieve VBN cord-015021-pol2qm74 5468 26 . . . cord-015021-pol2qm74 5469 1 The the DT cord-015021-pol2qm74 5469 2 questions question NNS cord-015021-pol2qm74 5469 3 that that WDT cord-015021-pol2qm74 5469 4 are be VBP cord-015021-pol2qm74 5469 5 unresolved unresolved JJ cord-015021-pol2qm74 5469 6 in in IN cord-015021-pol2qm74 5469 7 each each DT cord-015021-pol2qm74 5469 8 area area NN cord-015021-pol2qm74 5469 9 of of IN cord-015021-pol2qm74 5469 10 investigation investigation NN cord-015021-pol2qm74 5469 11 serve serve VBP cord-015021-pol2qm74 5469 12 to to TO cord-015021-pol2qm74 5469 13 direct direct VB cord-015021-pol2qm74 5469 14 the the DT cord-015021-pol2qm74 5469 15 scientist scientist NN cord-015021-pol2qm74 5469 16 towards towards IN cord-015021-pol2qm74 5469 17 analyses analysis NNS cord-015021-pol2qm74 5469 18 of of IN cord-015021-pol2qm74 5469 19 gene gene NN cord-015021-pol2qm74 5469 20 products product NNS cord-015021-pol2qm74 5469 21 or or CC cord-015021-pol2qm74 5469 22 gene gene NN cord-015021-pol2qm74 5469 23 regulation regulation NN cord-015021-pol2qm74 5469 24 of of IN cord-015021-pol2qm74 5469 25 the the DT cord-015021-pol2qm74 5469 26 gene gene NN cord-015021-pol2qm74 5469 27 itself -PRON- PRP cord-015021-pol2qm74 5469 28 . . . cord-015021-pol2qm74 5470 1 Thus thus RB cord-015021-pol2qm74 5470 2 , , , cord-015021-pol2qm74 5470 3 selection selection NN cord-015021-pol2qm74 5470 4 of of IN cord-015021-pol2qm74 5470 5 the the DT cord-015021-pol2qm74 5470 6 type type NN cord-015021-pol2qm74 5470 7 of of IN cord-015021-pol2qm74 5470 8 library library NN cord-015021-pol2qm74 5470 9 ( ( -LRB- cord-015021-pol2qm74 5470 10 genomic genomic JJ cord-015021-pol2qm74 5470 11 or or CC cord-015021-pol2qm74 5470 12 cDNA cdna NN cord-015021-pol2qm74 5470 13 ) ) -RRB- cord-015021-pol2qm74 5470 14 to to TO cord-015021-pol2qm74 5470 15 be be VB cord-015021-pol2qm74 5470 16 used use VBN cord-015021-pol2qm74 5470 17 is be VBZ cord-015021-pol2qm74 5470 18 dependent dependent JJ cord-015021-pol2qm74 5470 19 upon upon IN cord-015021-pol2qm74 5470 20 the the DT cord-015021-pol2qm74 5470 21 specific specific JJ cord-015021-pol2qm74 5470 22 goals goal NNS cord-015021-pol2qm74 5470 23 of of IN cord-015021-pol2qm74 5470 24 each each DT cord-015021-pol2qm74 5470 25 investigator investigator NN cord-015021-pol2qm74 5470 26 . . . cord-015021-pol2qm74 5471 1 To to TO cord-015021-pol2qm74 5471 2 facilitate facilitate VB cord-015021-pol2qm74 5471 3 resolution resolution NN cord-015021-pol2qm74 5471 4 of of IN cord-015021-pol2qm74 5471 5 this this DT cord-015021-pol2qm74 5471 6 question question NN cord-015021-pol2qm74 5471 7 , , , cord-015021-pol2qm74 5471 8 an an DT cord-015021-pol2qm74 5471 9 overview overview NN cord-015021-pol2qm74 5471 10 of of IN cord-015021-pol2qm74 5471 11 the the DT cord-015021-pol2qm74 5471 12 uses use NNS cord-015021-pol2qm74 5471 13 for for IN cord-015021-pol2qm74 5471 14 the the DT cord-015021-pol2qm74 5471 15 different different JJ cord-015021-pol2qm74 5471 16 types type NNS cord-015021-pol2qm74 5471 17 of of IN cord-015021-pol2qm74 5471 18 libraries library NNS cord-015021-pol2qm74 5471 19 will will MD cord-015021-pol2qm74 5471 20 be be VB cord-015021-pol2qm74 5471 21 presented present VBN cord-015021-pol2qm74 5471 22 . . . cord-015021-pol2qm74 5472 1 At at RB cord-015021-pol2qm74 5472 2 least least JJS cord-015021-pol2qm74 5472 3 four four CD cord-015021-pol2qm74 5472 4 methodologies methodology NNS cord-015021-pol2qm74 5472 5 are be VBP cord-015021-pol2qm74 5472 6 currently currently RB cord-015021-pol2qm74 5472 7 available available JJ cord-015021-pol2qm74 5472 8 for for IN cord-015021-pol2qm74 5472 9 screening screen VBG cord-015021-pol2qm74 5472 10 a a DT cord-015021-pol2qm74 5472 11 library library NN cord-015021-pol2qm74 5472 12 , , , cord-015021-pol2qm74 5472 13 which which WDT cord-015021-pol2qm74 5472 14 are be VBP cord-015021-pol2qm74 5472 15 dependent dependent JJ cord-015021-pol2qm74 5472 16 upon upon IN cord-015021-pol2qm74 5472 17 specific specific JJ cord-015021-pol2qm74 5472 18 interaction interaction NN cord-015021-pol2qm74 5472 19 between between IN cord-015021-pol2qm74 5472 20 nucleic nucleic JJ cord-015021-pol2qm74 5472 21 acids acid NNS cord-015021-pol2qm74 5472 22 , , , cord-015021-pol2qm74 5472 23 nucleic nucleic JJ cord-015021-pol2qm74 5472 24 acids acid NNS cord-015021-pol2qm74 5472 25 and and CC cord-015021-pol2qm74 5472 26 proteins protein NNS cord-015021-pol2qm74 5472 27 , , , cord-015021-pol2qm74 5472 28 antibodies antibody NNS cord-015021-pol2qm74 5472 29 and and CC cord-015021-pol2qm74 5472 30 antigens antigen NNS cord-015021-pol2qm74 5472 31 or or CC cord-015021-pol2qm74 5472 32 between between IN cord-015021-pol2qm74 5472 33 different different JJ cord-015021-pol2qm74 5472 34 proteins protein NNS cord-015021-pol2qm74 5472 35 . . . cord-015021-pol2qm74 5473 1 The the DT cord-015021-pol2qm74 5473 2 use use NN cord-015021-pol2qm74 5473 3 and and CC cord-015021-pol2qm74 5473 4 advantages advantage NNS cord-015021-pol2qm74 5473 5 of of IN cord-015021-pol2qm74 5473 6 each each DT cord-015021-pol2qm74 5473 7 of of IN cord-015021-pol2qm74 5473 8 these these DT cord-015021-pol2qm74 5473 9 methodologies methodology NNS cord-015021-pol2qm74 5473 10 will will MD cord-015021-pol2qm74 5473 11 be be VB cord-015021-pol2qm74 5473 12 discussed discuss VBN cord-015021-pol2qm74 5473 13 along along IN cord-015021-pol2qm74 5473 14 with with IN cord-015021-pol2qm74 5473 15 a a DT cord-015021-pol2qm74 5473 16 description description NN cord-015021-pol2qm74 5473 17 of of IN cord-015021-pol2qm74 5473 18 probe probe NN cord-015021-pol2qm74 5473 19 preparation preparation NN cord-015021-pol2qm74 5473 20 . . . cord-015021-pol2qm74 5474 1 Sequence sequence NN cord-015021-pol2qm74 5474 2 methodologies methodology NNS cord-015021-pol2qm74 5474 3 required require VBN cord-015021-pol2qm74 5474 4 to to TO cord-015021-pol2qm74 5474 5 begin begin VB cord-015021-pol2qm74 5474 6 characterization characterization NN cord-015021-pol2qm74 5474 7 of of IN cord-015021-pol2qm74 5474 8 gene gene NN cord-015021-pol2qm74 5474 9 clones clone NNS cord-015021-pol2qm74 5474 10 will will MD cord-015021-pol2qm74 5474 11 be be VB cord-015021-pol2qm74 5474 12 presented present VBN cord-015021-pol2qm74 5474 13 . . . cord-015021-pol2qm74 5475 1 Hopefully hopefully RB cord-015021-pol2qm74 5475 2 , , , cord-015021-pol2qm74 5475 3 the the DT cord-015021-pol2qm74 5475 4 participants participant NNS cord-015021-pol2qm74 5475 5 in in IN cord-015021-pol2qm74 5475 6 the the DT cord-015021-pol2qm74 5475 7 workshop workshop NN cord-015021-pol2qm74 5475 8 will will MD cord-015021-pol2qm74 5475 9 help help VB cord-015021-pol2qm74 5475 10 define define VB cord-015021-pol2qm74 5475 11 areas area NNS cord-015021-pol2qm74 5475 12 of of IN cord-015021-pol2qm74 5475 13 emphasis emphasis NN cord-015021-pol2qm74 5475 14 and and CC cord-015021-pol2qm74 5475 15 allow allow VB cord-015021-pol2qm74 5475 16 time time NN cord-015021-pol2qm74 5475 17 for for IN cord-015021-pol2qm74 5475 18 directed direct VBN cord-015021-pol2qm74 5475 19 interaction interaction NN cord-015021-pol2qm74 5475 20 to to TO cord-015021-pol2qm74 5475 21 discuss discuss VB cord-015021-pol2qm74 5475 22 specific specific JJ cord-015021-pol2qm74 5475 23 applications application NNS cord-015021-pol2qm74 5475 24 based base VBN cord-015021-pol2qm74 5475 25 upon upon IN cord-015021-pol2qm74 5475 26 their -PRON- PRP$ cord-015021-pol2qm74 5475 27 own own JJ cord-015021-pol2qm74 5475 28 experimental experimental JJ cord-015021-pol2qm74 5475 29 systems system NNS cord-015021-pol2qm74 5475 30 . . . cord-015021-pol2qm74 5475 31 _SP cord-015021-pol2qm74 5476 1 Alterations alteration NNS cord-015021-pol2qm74 5476 2 of of IN cord-015021-pol2qm74 5476 3 physiological physiological JJ cord-015021-pol2qm74 5476 4 conditions condition NNS cord-015021-pol2qm74 5476 5 , , , cord-015021-pol2qm74 5476 6 such such JJ cord-015021-pol2qm74 5476 7 as as IN cord-015021-pol2qm74 5476 8 those those DT cord-015021-pol2qm74 5476 9 occurring occur VBG cord-015021-pol2qm74 5476 10 after after IN cord-015021-pol2qm74 5476 11 shock shock NN cord-015021-pol2qm74 5476 12 and and CC cord-015021-pol2qm74 5476 13 sepsis sepsis NN cord-015021-pol2qm74 5476 14 , , , cord-015021-pol2qm74 5476 15 induce induce VB cord-015021-pol2qm74 5476 16 changes change NNS cord-015021-pol2qm74 5476 17 in in IN cord-015021-pol2qm74 5476 18 gene gene NN cord-015021-pol2qm74 5476 19 expression expression NN cord-015021-pol2qm74 5476 20 of of IN cord-015021-pol2qm74 5476 21 cells cell NNS cord-015021-pol2qm74 5476 22 composing compose VBG cord-015021-pol2qm74 5476 23 the the DT cord-015021-pol2qm74 5476 24 major major JJ cord-015021-pol2qm74 5476 25 organ organ NN cord-015021-pol2qm74 5476 26 systems system NNS cord-015021-pol2qm74 5476 27 . . . cord-015021-pol2qm74 5477 1 The the DT cord-015021-pol2qm74 5477 2 challenge challenge NN cord-015021-pol2qm74 5477 3 is be VBZ cord-015021-pol2qm74 5477 4 to to TO cord-015021-pol2qm74 5477 5 detect detect VB cord-015021-pol2qm74 5477 6 and and CC cord-015021-pol2qm74 5477 7 characterize characterize VB cord-015021-pol2qm74 5477 8 these these DT cord-015021-pol2qm74 5477 9 changes change NNS cord-015021-pol2qm74 5477 10 in in IN cord-015021-pol2qm74 5477 11 geae geae NNP cord-015021-pol2qm74 5477 12 expression expression NN cord-015021-pol2qm74 5477 13 and and CC cord-015021-pol2qm74 5477 14 relate relate VB cord-015021-pol2qm74 5477 15 them -PRON- PRP cord-015021-pol2qm74 5477 16 to to IN cord-015021-pol2qm74 5477 17 the the DT cord-015021-pol2qm74 5477 18 injury injury NN cord-015021-pol2qm74 5477 19 . . . cord-015021-pol2qm74 5478 1 The the DT cord-015021-pol2qm74 5478 2 development development NN cord-015021-pol2qm74 5478 3 of of IN cord-015021-pol2qm74 5478 4 cloning clone VBG cord-015021-pol2qm74 5478 5 techniques technique NNS cord-015021-pol2qm74 5478 6 has have VBZ cord-015021-pol2qm74 5478 7 emerged emerge VBN cord-015021-pol2qm74 5478 8 as as IN cord-015021-pol2qm74 5478 9 the the DT cord-015021-pol2qm74 5478 10 methodology methodology NN cord-015021-pol2qm74 5478 11 of of IN cord-015021-pol2qm74 5478 12 choice choice NN cord-015021-pol2qm74 5478 13 . . . cord-015021-pol2qm74 5479 1 Changes change NNS cord-015021-pol2qm74 5479 2 in in IN cord-015021-pol2qm74 5479 3 gene gene NN cord-015021-pol2qm74 5479 4 expression expression NN cord-015021-pol2qm74 5479 5 are be VBP cord-015021-pol2qm74 5479 6 usually usually RB cord-015021-pol2qm74 5479 7 characterized characterize VBN cord-015021-pol2qm74 5479 8 by by IN cord-015021-pol2qm74 5479 9 variations variation NNS cord-015021-pol2qm74 5479 10 in in IN cord-015021-pol2qm74 5479 11 the the DT cord-015021-pol2qm74 5479 12 concentration concentration NN cord-015021-pol2qm74 5479 13 of of IN cord-015021-pol2qm74 5479 14 cellular cellular JJ cord-015021-pol2qm74 5479 15 messages message NNS cord-015021-pol2qm74 5479 16 because because IN cord-015021-pol2qm74 5479 17 synthesis synthesis NN cord-015021-pol2qm74 5479 18 of of IN cord-015021-pol2qm74 5479 19 the the DT cord-015021-pol2qm74 5479 20 final final JJ cord-015021-pol2qm74 5479 21 product product NN cord-015021-pol2qm74 5479 22 " " `` cord-015021-pol2qm74 5479 23 the the DT cord-015021-pol2qm74 5479 24 polypoptide polypoptide NN cord-015021-pol2qm74 5479 25 " " `` cord-015021-pol2qm74 5479 26 is be VBZ cord-015021-pol2qm74 5479 27 usually usually RB cord-015021-pol2qm74 5479 28 proportional proportional JJ cord-015021-pol2qm74 5479 29 to to IN cord-015021-pol2qm74 5479 30 the the DT cord-015021-pol2qm74 5479 31 concentration concentration NN cord-015021-pol2qm74 5479 32 of of IN cord-015021-pol2qm74 5479 33 mRNA mRNA NNP cord-015021-pol2qm74 5479 34 . . . cord-015021-pol2qm74 5480 1 Due due IN cord-015021-pol2qm74 5480 2 to to IN cord-015021-pol2qm74 5480 3 the the DT cord-015021-pol2qm74 5480 4 rapid rapid JJ cord-015021-pol2qm74 5480 5 regulation regulation NN cord-015021-pol2qm74 5480 6 of of IN cord-015021-pol2qm74 5480 7 gene gene NN cord-015021-pol2qm74 5480 8 expression expression NN cord-015021-pol2qm74 5480 9 the the DT cord-015021-pol2qm74 5480 10 cellular cellular JJ cord-015021-pol2qm74 5480 11 concentration concentration NN cord-015021-pol2qm74 5480 12 of of IN cord-015021-pol2qm74 5480 13 messages message NNS cord-015021-pol2qm74 5480 14 changes change NNS cord-015021-pol2qm74 5480 15 very very RB cord-015021-pol2qm74 5480 16 quickly quickly RB cord-015021-pol2qm74 5480 17 . . . cord-015021-pol2qm74 5481 1 This this DT cord-015021-pol2qm74 5481 2 is be VBZ cord-015021-pol2qm74 5481 3 commonly commonly RB cord-015021-pol2qm74 5481 4 referred refer VBN cord-015021-pol2qm74 5481 5 to to IN cord-015021-pol2qm74 5481 6 as as RB cord-015021-pol2qm74 5481 7 steady steady JJ cord-015021-pol2qm74 5481 8 - - HYPH cord-015021-pol2qm74 5481 9 state state NN cord-015021-pol2qm74 5481 10 levels level NNS cord-015021-pol2qm74 5481 11 , , , cord-015021-pol2qm74 5481 12 a a DT cord-015021-pol2qm74 5481 13 balance balance NN cord-015021-pol2qm74 5481 14 between between IN cord-015021-pol2qm74 5481 15 transcription transcription NN cord-015021-pol2qm74 5481 16 and and CC cord-015021-pol2qm74 5481 17 degradation degradation NN cord-015021-pol2qm74 5481 18 . . . cord-015021-pol2qm74 5482 1 Steady steady JJ cord-015021-pol2qm74 5482 2 - - HYPH cord-015021-pol2qm74 5482 3 state state NN cord-015021-pol2qm74 5482 4 levels level NNS cord-015021-pol2qm74 5482 5 of of IN cord-015021-pol2qm74 5482 6 mRNA mrna NN cord-015021-pol2qm74 5482 7 can can MD cord-015021-pol2qm74 5482 8 be be VB cord-015021-pol2qm74 5482 9 detected detect VBN cord-015021-pol2qm74 5482 10 in in IN cord-015021-pol2qm74 5482 11 a a DT cord-015021-pol2qm74 5482 12 single single JJ cord-015021-pol2qm74 5482 13 cell cell NN cord-015021-pol2qm74 5482 14 ( ( -LRB- cord-015021-pol2qm74 5482 15 in in IN cord-015021-pol2qm74 5482 16 situ situ NN cord-015021-pol2qm74 5482 17 hybridization hybridization NN cord-015021-pol2qm74 5482 18 ) ) -RRB- cord-015021-pol2qm74 5482 19 or or CC cord-015021-pol2qm74 5482 20 in in IN cord-015021-pol2qm74 5482 21 total total JJ cord-015021-pol2qm74 5482 22 RNA RNA NNP cord-015021-pol2qm74 5482 23 isolated isolate VBN cord-015021-pol2qm74 5482 24 from from IN cord-015021-pol2qm74 5482 25 cells cell NNS cord-015021-pol2qm74 5482 26 or or CC cord-015021-pol2qm74 5482 27 organs organ NNS cord-015021-pol2qm74 5482 28 and and CC cord-015021-pol2qm74 5482 29 separated separate VBD cord-015021-pol2qm74 5482 30 in in IN cord-015021-pol2qm74 5482 31 agarose agarose JJ cord-015021-pol2qm74 5482 32 gels gel NNS cord-015021-pol2qm74 5482 33 ( ( -LRB- cord-015021-pol2qm74 5482 34 Northern northern JJ cord-015021-pol2qm74 5482 35 blots blot NNS cord-015021-pol2qm74 5482 36 ) ) -RRB- cord-015021-pol2qm74 5482 37 . . . cord-015021-pol2qm74 5483 1 Although although IN cord-015021-pol2qm74 5483 2 analysis analysis NN cord-015021-pol2qm74 5483 3 of of IN cord-015021-pol2qm74 5483 4 mRNA mRNA NNP cord-015021-pol2qm74 5483 5 steady steady JJ cord-015021-pol2qm74 5483 6 - - HYPH cord-015021-pol2qm74 5483 7 state state NN cord-015021-pol2qm74 5483 8 levels level NNS cord-015021-pol2qm74 5483 9 are be VBP cord-015021-pol2qm74 5483 10 very very RB cord-015021-pol2qm74 5483 11 useful useful JJ cord-015021-pol2qm74 5483 12 , , , cord-015021-pol2qm74 5483 13 they -PRON- PRP cord-015021-pol2qm74 5483 14 do do VBP cord-015021-pol2qm74 5483 15 not not RB cord-015021-pol2qm74 5483 16 provide provide VB cord-015021-pol2qm74 5483 17 information information NN cord-015021-pol2qm74 5483 18 about about IN cord-015021-pol2qm74 5483 19 the the DT cord-015021-pol2qm74 5483 20 mechanisms mechanism NNS cord-015021-pol2qm74 5483 21 that that WDT cord-015021-pol2qm74 5483 22 regulate regulate VBP cord-015021-pol2qm74 5483 23 gene gene NN cord-015021-pol2qm74 5483 24 expression expression NN cord-015021-pol2qm74 5483 25 . . . cord-015021-pol2qm74 5484 1 Changes change NNS cord-015021-pol2qm74 5484 2 in in IN cord-015021-pol2qm74 5484 3 gene gene NN cord-015021-pol2qm74 5484 4 expression expression NN cord-015021-pol2qm74 5484 5 primarily primarily RB cord-015021-pol2qm74 5484 6 occur occur VBP cord-015021-pol2qm74 5484 7 at at IN cord-015021-pol2qm74 5484 8 the the DT cord-015021-pol2qm74 5484 9 level level NN cord-015021-pol2qm74 5484 10 of of IN cord-015021-pol2qm74 5484 11 transcription transcription NN cord-015021-pol2qm74 5484 12 ; ; : cord-015021-pol2qm74 5484 13 characterization characterization NN cord-015021-pol2qm74 5484 14 of of IN cord-015021-pol2qm74 5484 15 the the DT cord-015021-pol2qm74 5484 16 RNA RNA NNP cord-015021-pol2qm74 5484 17 species specie NNS cord-015021-pol2qm74 5484 18 being be VBG cord-015021-pol2qm74 5484 19 synthesized synthesize VBN cord-015021-pol2qm74 5484 20 at at IN cord-015021-pol2qm74 5484 21 a a DT cord-015021-pol2qm74 5484 22 given give VBN cord-015021-pol2qm74 5484 23 time time NN cord-015021-pol2qm74 5484 24 is be VBZ cord-015021-pol2qm74 5484 25 performed perform VBN cord-015021-pol2qm74 5484 26 by by IN cord-015021-pol2qm74 5484 27 the the DT cord-015021-pol2qm74 5484 28 nuclear nuclear JJ cord-015021-pol2qm74 5484 29 run run NN cord-015021-pol2qm74 5484 30 - - HYPH cord-015021-pol2qm74 5484 31 off off RP cord-015021-pol2qm74 5484 32 technique technique NN cord-015021-pol2qm74 5484 33 . . . cord-015021-pol2qm74 5485 1 When when WRB cord-015021-pol2qm74 5485 2 there there EX cord-015021-pol2qm74 5485 3 is be VBZ cord-015021-pol2qm74 5485 4 no no DT cord-015021-pol2qm74 5485 5 a a FW cord-015021-pol2qm74 5485 6 priori priori FW cord-015021-pol2qm74 5485 7 information information NN cord-015021-pol2qm74 5485 8 about about IN cord-015021-pol2qm74 5485 9 the the DT cord-015021-pol2qm74 5485 10 gene gene NN cord-015021-pol2qm74 5485 11 that that WDT cord-015021-pol2qm74 5485 12 may may MD cord-015021-pol2qm74 5485 13 be be VB cord-015021-pol2qm74 5485 14 regulated regulate VBN cord-015021-pol2qm74 5485 15 after after IN cord-015021-pol2qm74 5485 16 a a DT cord-015021-pol2qm74 5485 17 particular particular JJ cord-015021-pol2qm74 5485 18 situation situation NN cord-015021-pol2qm74 5485 19 such such JJ cord-015021-pol2qm74 5485 20 as as IN cord-015021-pol2qm74 5485 21 sepsis sepsis NN cord-015021-pol2qm74 5485 22 , , , cord-015021-pol2qm74 5485 23 the the DT cord-015021-pol2qm74 5485 24 total total JJ cord-015021-pol2qm74 5485 25 pool pool NN cord-015021-pol2qm74 5485 26 of of IN cord-015021-pol2qm74 5485 27 messages message NNS cord-015021-pol2qm74 5485 28 present present JJ cord-015021-pol2qm74 5485 29 in in IN cord-015021-pol2qm74 5485 30 cells cell NNS cord-015021-pol2qm74 5485 31 at at IN cord-015021-pol2qm74 5485 32 given give VBN cord-015021-pol2qm74 5485 33 time time NN cord-015021-pol2qm74 5485 34 can can MD cord-015021-pol2qm74 5485 35 be be VB cord-015021-pol2qm74 5485 36 characterized characterize VBN cord-015021-pol2qm74 5485 37 by by IN cord-015021-pol2qm74 5485 38 a a DT cord-015021-pol2qm74 5485 39 combination combination NN cord-015021-pol2qm74 5485 40 of of IN cord-015021-pol2qm74 5485 41 in in FW cord-015021-pol2qm74 5485 42 vitro vitro FW cord-015021-pol2qm74 5485 43 translation translation NN cord-015021-pol2qm74 5485 44 of of IN cord-015021-pol2qm74 5485 45 the the DT cord-015021-pol2qm74 5485 46 cellular cellular JJ cord-015021-pol2qm74 5485 47 messages message NNS cord-015021-pol2qm74 5485 48 and and CC cord-015021-pol2qm74 5485 49 fractionation fractionation NN cord-015021-pol2qm74 5485 50 of of IN cord-015021-pol2qm74 5485 51 the the DT cord-015021-pol2qm74 5485 52 in in FW cord-015021-pol2qm74 5485 53 vitro vitro FW cord-015021-pol2qm74 5485 54 translated translate VBN cord-015021-pol2qm74 5485 55 products product NNS cord-015021-pol2qm74 5485 56 by by IN cord-015021-pol2qm74 5485 57 two two CD cord-015021-pol2qm74 5485 58 dimensional dimensional JJ cord-015021-pol2qm74 5485 59 gel gel NN cord-015021-pol2qm74 5485 60 electrophoresis electrophoresis NN cord-015021-pol2qm74 5485 61 . . . cord-015021-pol2qm74 5486 1 Such such JJ cord-015021-pol2qm74 5486 2 approach approach NN cord-015021-pol2qm74 5486 3 permits permit VBZ cord-015021-pol2qm74 5486 4 the the DT cord-015021-pol2qm74 5486 5 visualization visualization NN cord-015021-pol2qm74 5486 6 of of IN cord-015021-pol2qm74 5486 7 the the DT cord-015021-pol2qm74 5486 8 general general JJ cord-015021-pol2qm74 5486 9 pattern pattern NN cord-015021-pol2qm74 5486 10 of of IN cord-015021-pol2qm74 5486 11 gene gene NN cord-015021-pol2qm74 5486 12 expression expression NN cord-015021-pol2qm74 5486 13 , , , cord-015021-pol2qm74 5486 14 a a DT cord-015021-pol2qm74 5486 15 " " `` cord-015021-pol2qm74 5486 16 finger finger NN cord-015021-pol2qm74 5486 17 print print NN cord-015021-pol2qm74 5486 18 " " '' cord-015021-pol2qm74 5486 19 , , , cord-015021-pol2qm74 5486 20 of of IN cord-015021-pol2qm74 5486 21 the the DT cord-015021-pol2qm74 5486 22 physiologic physiologic JJ cord-015021-pol2qm74 5486 23 state state NN cord-015021-pol2qm74 5486 24 . . . cord-015021-pol2qm74 5487 1 In in IN cord-015021-pol2qm74 5487 2 summary summary NN cord-015021-pol2qm74 5487 3 , , , cord-015021-pol2qm74 5487 4 researchers researcher NNS cord-015021-pol2qm74 5487 5 now now RB cord-015021-pol2qm74 5487 6 have have VBP cord-015021-pol2qm74 5487 7 access access NN cord-015021-pol2qm74 5487 8 to to IN cord-015021-pol2qm74 5487 9 a a DT cord-015021-pol2qm74 5487 10 great great JJ cord-015021-pol2qm74 5487 11 variety variety NN cord-015021-pol2qm74 5487 12 of of IN cord-015021-pol2qm74 5487 13 techniques technique NNS cord-015021-pol2qm74 5487 14 to to TO cord-015021-pol2qm74 5487 15 identify identify VB cord-015021-pol2qm74 5487 16 and and CC cord-015021-pol2qm74 5487 17 characterize characterize VB cord-015021-pol2qm74 5487 18 genes gene NNS cord-015021-pol2qm74 5487 19 expressed express VBN cord-015021-pol2qm74 5487 20 in in IN cord-015021-pol2qm74 5487 21 response response NN cord-015021-pol2qm74 5487 22 to to IN cord-015021-pol2qm74 5487 23 a a DT cord-015021-pol2qm74 5487 24 physiological physiological JJ cord-015021-pol2qm74 5487 25 condition condition NN cord-015021-pol2qm74 5487 26 that that WDT cord-015021-pol2qm74 5487 27 may may MD cord-015021-pol2qm74 5487 28 be be VB cord-015021-pol2qm74 5487 29 utilized utilize VBN cord-015021-pol2qm74 5487 30 as as IN cord-015021-pol2qm74 5487 31 " " `` cord-015021-pol2qm74 5487 32 molecular molecular JJ cord-015021-pol2qm74 5487 33 tools tool NNS cord-015021-pol2qm74 5487 34 " " '' cord-015021-pol2qm74 5487 35 to to TO cord-015021-pol2qm74 5487 36 study study VB cord-015021-pol2qm74 5487 37 the the DT cord-015021-pol2qm74 5487 38 organism organism NN cord-015021-pol2qm74 5487 39 's 's POS cord-015021-pol2qm74 5487 40 responses response NNS cord-015021-pol2qm74 5487 41 to to TO cord-015021-pol2qm74 5487 42 shock shock VB cord-015021-pol2qm74 5487 43 and and CC cord-015021-pol2qm74 5487 44 sepsis sepsis NN cord-015021-pol2qm74 5487 45 . . . cord-015021-pol2qm74 5488 1 The the DT cord-015021-pol2qm74 5488 2 acute acute JJ cord-015021-pol2qm74 5488 3 phase phase NN cord-015021-pol2qm74 5488 4 proteins protein NNS cord-015021-pol2qm74 5488 5 are be VBP cord-015021-pol2qm74 5488 6 a a DT cord-015021-pol2qm74 5488 7 set set NN cord-015021-pol2qm74 5488 8 of of IN cord-015021-pol2qm74 5488 9 plasma plasma NN cord-015021-pol2qm74 5488 10 proteins protein NNS cord-015021-pol2qm74 5488 11 with with IN cord-015021-pol2qm74 5488 12 greatly greatly RB cord-015021-pol2qm74 5488 13 increased increase VBN cord-015021-pol2qm74 5488 14 plasma plasma NN cord-015021-pol2qm74 5488 15 concentrations concentration NNS cord-015021-pol2qm74 5488 16 during during IN cord-015021-pol2qm74 5488 17 acute acute JJ cord-015021-pol2qm74 5488 18 inflammations inflammation NNS cord-015021-pol2qm74 5488 19 and and CC cord-015021-pol2qm74 5488 20 after after IN cord-015021-pol2qm74 5488 21 tissue tissue NN cord-015021-pol2qm74 5488 22 trauma trauma NN cord-015021-pol2qm74 5488 23 , , , cord-015021-pol2qm74 5488 24 e.g. e.g. RB cord-015021-pol2qm74 5488 25 after after IN cord-015021-pol2qm74 5488 26 major major JJ cord-015021-pol2qm74 5488 27 surgery surgery NN cord-015021-pol2qm74 5488 28 . . . cord-015021-pol2qm74 5489 1 The the DT cord-015021-pol2qm74 5489 2 proteins protein NNS cord-015021-pol2qm74 5489 3 counteract counteract VBP cord-015021-pol2qm74 5489 4 the the DT cord-015021-pol2qm74 5489 5 source source NN cord-015021-pol2qm74 5489 6 of of IN cord-015021-pol2qm74 5489 7 injury injury NN cord-015021-pol2qm74 5489 8 , , , cord-015021-pol2qm74 5489 9 facilitate facilitate VB cord-015021-pol2qm74 5489 10 clearance clearance NN cord-015021-pol2qm74 5489 11 of of IN cord-015021-pol2qm74 5489 12 infectious infectious JJ cord-015021-pol2qm74 5489 13 particles particle NNS cord-015021-pol2qm74 5489 14 by by IN cord-015021-pol2qm74 5489 15 phagocytes phagocyte NNS cord-015021-pol2qm74 5489 16 , , , cord-015021-pol2qm74 5489 17 assist assist VB cord-015021-pol2qm74 5489 18 immune immune JJ cord-015021-pol2qm74 5489 19 responses response NNS cord-015021-pol2qm74 5489 20 and and CC cord-015021-pol2qm74 5489 21 initiate initiate VB cord-015021-pol2qm74 5489 22 wound wind VBN cord-015021-pol2qm74 5489 23 healing healing NN cord-015021-pol2qm74 5489 24 . . . cord-015021-pol2qm74 5490 1 The the DT cord-015021-pol2qm74 5490 2 corresponding corresponding JJ cord-015021-pol2qm74 5490 3 genes gene NNS cord-015021-pol2qm74 5490 4 are be VBP cord-015021-pol2qm74 5490 5 expressed express VBN cord-015021-pol2qm74 5490 6 in in IN cord-015021-pol2qm74 5490 7 liver liver NN cord-015021-pol2qm74 5490 8 hepatocytes hepatocyte NNS cord-015021-pol2qm74 5490 9 and and CC cord-015021-pol2qm74 5490 10 regulated regulate VBN cord-015021-pol2qm74 5490 11 by by IN cord-015021-pol2qm74 5490 12 the the DT cord-015021-pol2qm74 5490 13 inflammatory inflammatory JJ cord-015021-pol2qm74 5490 14 mediators mediator NNS cord-015021-pol2qm74 5490 15 interleukin interleukin NN cord-015021-pol2qm74 5490 16 1 1 CD cord-015021-pol2qm74 5490 17 and and CC cord-015021-pol2qm74 5490 18 interleukin interleukin NN cord-015021-pol2qm74 5490 19 6 6 CD cord-015021-pol2qm74 5490 20 ( ( -LRB- cord-015021-pol2qm74 5490 21 ILl ILl NNP cord-015021-pol2qm74 5490 22 , , , cord-015021-pol2qm74 5490 23 IL6 IL6 NNP cord-015021-pol2qm74 5490 24 ) ) -RRB- cord-015021-pol2qm74 5490 25 . . . cord-015021-pol2qm74 5491 1 Class1 Class1 NNP cord-015021-pol2qm74 5492 1 acute acute JJ cord-015021-pol2qm74 5492 2 phase phase NN cord-015021-pol2qm74 5492 3 genes gene NNS cord-015021-pol2qm74 5492 4 are be VBP cord-015021-pol2qm74 5492 5 mainly mainly RB cord-015021-pol2qm74 5492 6 controlled control VBN cord-015021-pol2qm74 5492 7 by by IN cord-015021-pol2qm74 5492 8 ILl ILl NNS cord-015021-pol2qm74 5492 9 and and CC cord-015021-pol2qm74 5492 10 by by IN cord-015021-pol2qm74 5492 11 combinations combination NNS cord-015021-pol2qm74 5492 12 of of IN cord-015021-pol2qm74 5492 13 ILl ILl NNP cord-015021-pol2qm74 5492 14 plus plus CC cord-015021-pol2qm74 5492 15 IL6 IL6 NNP cord-015021-pol2qm74 5492 16 ; ; : cord-015021-pol2qm74 5492 17 class2 class2 NNP cord-015021-pol2qm74 5492 18 genes gene NNS cord-015021-pol2qm74 5492 19 mainly mainly RB cord-015021-pol2qm74 5492 20 by by IN cord-015021-pol2qm74 5492 21 ii,6 ii,6 NNP cord-015021-pol2qm74 5492 22 . . . cord-015021-pol2qm74 5493 1 The the DT cord-015021-pol2qm74 5493 2 human human JJ cord-015021-pol2qm74 5493 3 C c NN cord-015021-pol2qm74 5493 4 - - HYPH cord-015021-pol2qm74 5493 5 reactive reactive JJ cord-015021-pol2qm74 5493 6 protein(CRP protein(crp CD cord-015021-pol2qm74 5493 7 ) ) -RRB- cord-015021-pol2qm74 5493 8 , , , cord-015021-pol2qm74 5493 9 serum serum NN cord-015021-pol2qm74 5493 10 amyloid amyloid NN cord-015021-pol2qm74 5493 11 A(SAA A(SAA NNP cord-015021-pol2qm74 5493 12 ) ) -RRB- cord-015021-pol2qm74 5493 13 and and CC cord-015021-pol2qm74 5493 14 complement complement VB cord-015021-pol2qm74 5493 15 C3 C3 NNP cord-015021-pol2qm74 5493 16 genes gene NNS cord-015021-pol2qm74 5493 17 will will MD cord-015021-pol2qm74 5493 18 be be VB cord-015021-pol2qm74 5493 19 discussed discuss VBN cord-015021-pol2qm74 5493 20 as as IN cord-015021-pol2qm74 5493 21 examples example NNS cord-015021-pol2qm74 5493 22 of of IN cord-015021-pol2qm74 5493 23 class1 class1 NNP cord-015021-pol2qm74 5493 24 genes gene NNS cord-015021-pol2qm74 5493 25 , , , cord-015021-pol2qm74 5493 26 and and CC cord-015021-pol2qm74 5493 27 rat rat NN cord-015021-pol2qm74 5493 28 c~2 c~2 NNP cord-015021-pol2qm74 5493 29 macroglobulin macroglobulin NNP cord-015021-pol2qm74 5493 30 as as IN cord-015021-pol2qm74 5493 31 a a DT cord-015021-pol2qm74 5493 32 prototypical prototypical JJ cord-015021-pol2qm74 5493 33 class2 class2 NN cord-015021-pol2qm74 5493 34 gene gene NN cord-015021-pol2qm74 5493 35 . . . cord-015021-pol2qm74 5494 1 Both both DT cord-015021-pol2qm74 5494 2 classes class NNS cord-015021-pol2qm74 5494 3 of of IN cord-015021-pol2qm74 5494 4 genes gene NNS cord-015021-pol2qm74 5494 5 use use VBP cord-015021-pol2qm74 5494 6 different different JJ cord-015021-pol2qm74 5494 7 types type NNS cord-015021-pol2qm74 5494 8 of of IN cord-015021-pol2qm74 5494 9 ¢ytokine ¢ytokine JJ cord-015021-pol2qm74 5494 10 response response NN cord-015021-pol2qm74 5494 11 elements element NNS cord-015021-pol2qm74 5494 12 in in IN cord-015021-pol2qm74 5494 13 their -PRON- PRP$ cord-015021-pol2qm74 5494 14 promoter promoter NN cord-015021-pol2qm74 5494 15 - - HYPH cord-015021-pol2qm74 5494 16 proximal proximal JJ cord-015021-pol2qm74 5494 17 transcription transcription NN cord-015021-pol2qm74 5494 18 control control NN cord-015021-pol2qm74 5494 19 regions region NNS cord-015021-pol2qm74 5494 20 ; ; : cord-015021-pol2qm74 5494 21 class1 class1 NN cord-015021-pol2qm74 5494 22 genes gene NNS cord-015021-pol2qm74 5494 23 use use VBP cord-015021-pol2qm74 5494 24 the the DT cord-015021-pol2qm74 5494 25 transcription transcription NN cord-015021-pol2qm74 5494 26 factor factor NN cord-015021-pol2qm74 5494 27 NF nf NN cord-015021-pol2qm74 5494 28 - - HYPH cord-015021-pol2qm74 5494 29 IL6 IL6 NNP cord-015021-pol2qm74 5494 30 or or CC cord-015021-pol2qm74 5494 31 C C NNP cord-015021-pol2qm74 5494 32 / / SYM cord-015021-pol2qm74 5494 33 EBP ebp NN cord-015021-pol2qm74 5494 34 as as IN cord-015021-pol2qm74 5494 35 the the DT cord-015021-pol2qm74 5494 36 key key JJ cord-015021-pol2qm74 5494 37 factor factor NN cord-015021-pol2qm74 5494 38 to to TO cord-015021-pol2qm74 5494 39 mediate mediate VB cord-015021-pol2qm74 5494 40 cytokine cytokine JJ cord-015021-pol2qm74 5494 41 responsiveness responsiveness NN cord-015021-pol2qm74 5494 42 ; ; : cord-015021-pol2qm74 5494 43 class2 class2 NNP cord-015021-pol2qm74 5494 44 genes gene NNS cord-015021-pol2qm74 5494 45 use use VBP cord-015021-pol2qm74 5494 46 a a DT cord-015021-pol2qm74 5494 47 different different JJ cord-015021-pol2qm74 5494 48 , , , cord-015021-pol2qm74 5494 49 so so RB cord-015021-pol2qm74 5494 50 far far RB cord-015021-pol2qm74 5494 51 unidentified unidentified JJ cord-015021-pol2qm74 5494 52 factor factor NN cord-015021-pol2qm74 5494 53 to to TO cord-015021-pol2qm74 5494 54 achieve achieve VB cord-015021-pol2qm74 5494 55 responsiveness responsiveness NN cord-015021-pol2qm74 5494 56 to to IN cord-015021-pol2qm74 5494 57 IL6 IL6 NNP cord-015021-pol2qm74 5494 58 . . . cord-015021-pol2qm74 5495 1 Ongoing ongoing JJ cord-015021-pol2qm74 5495 2 efforts effort NNS cord-015021-pol2qm74 5495 3 to to TO cord-015021-pol2qm74 5495 4 purify purify VB cord-015021-pol2qm74 5495 5 this this DT cord-015021-pol2qm74 5495 6 factor factor NN cord-015021-pol2qm74 5495 7 , , , cord-015021-pol2qm74 5495 8 called call VBD cord-015021-pol2qm74 5495 9 the the DT cord-015021-pol2qm74 5495 10 IL6-Response IL6-Response NNP cord-015021-pol2qm74 5495 11 Factor Factor NNP cord-015021-pol2qm74 5495 12 ( ( -LRB- cord-015021-pol2qm74 5495 13 IL6-RF il6-rf NN cord-015021-pol2qm74 5495 14 ) ) -RRB- cord-015021-pol2qm74 5495 15 , , , cord-015021-pol2qm74 5495 16 from from IN cord-015021-pol2qm74 5495 17 rat rat NN cord-015021-pol2qm74 5495 18 liver liver NN cord-015021-pol2qm74 5495 19 nuclear nuclear JJ cord-015021-pol2qm74 5495 20 protein protein NN cord-015021-pol2qm74 5495 21 extracts extract NNS cord-015021-pol2qm74 5495 22 will will MD cord-015021-pol2qm74 5495 23 be be VB cord-015021-pol2qm74 5495 24 described describe VBN cord-015021-pol2qm74 5495 25 . . . cord-015021-pol2qm74 5496 1 The the DT cord-015021-pol2qm74 5496 2 IL6-RF il6-rf NN cord-015021-pol2qm74 5496 3 apparently apparently RB cord-015021-pol2qm74 5496 4 mediates mediate VBZ cord-015021-pol2qm74 5496 5 the the DT cord-015021-pol2qm74 5496 6 effects effect NNS cord-015021-pol2qm74 5496 7 of of IN cord-015021-pol2qm74 5496 8 IL6 il6 NN cord-015021-pol2qm74 5496 9 in in IN cord-015021-pol2qm74 5496 10 a a DT cord-015021-pol2qm74 5496 11 broad broad JJ cord-015021-pol2qm74 5496 12 range range NN cord-015021-pol2qm74 5496 13 of of IN cord-015021-pol2qm74 5496 14 cell cell NN cord-015021-pol2qm74 5496 15 types type NNS cord-015021-pol2qm74 5496 16 , , , cord-015021-pol2qm74 5496 17 including include VBG cord-015021-pol2qm74 5496 18 B b NN cord-015021-pol2qm74 5496 19 lymphocytes lymphocyte NNS cord-015021-pol2qm74 5496 20 and and CC cord-015021-pol2qm74 5496 21 other other JJ cord-015021-pol2qm74 5496 22 hematopoietic hematopoietic JJ cord-015021-pol2qm74 5496 23 cells cell NNS cord-015021-pol2qm74 5496 24 . . . cord-015021-pol2qm74 5497 1 It -PRON- PRP cord-015021-pol2qm74 5497 2 is be VBZ cord-015021-pol2qm74 5497 3 therefore therefore RB cord-015021-pol2qm74 5497 4 likely likely JJ cord-015021-pol2qm74 5497 5 to to TO cord-015021-pol2qm74 5497 6 be be VB cord-015021-pol2qm74 5497 7 of of IN cord-015021-pol2qm74 5497 8 equal equal JJ cord-015021-pol2qm74 5497 9 general general JJ cord-015021-pol2qm74 5497 10 importance importance NN cord-015021-pol2qm74 5497 11 for for IN cord-015021-pol2qm74 5497 12 gene gene NN cord-015021-pol2qm74 5497 13 regulation regulation NN cord-015021-pol2qm74 5497 14 by by IN cord-015021-pol2qm74 5497 15 IL6 IL6 NNP cord-015021-pol2qm74 5497 16 as as IN cord-015021-pol2qm74 5497 17 NF NF NNP cord-015021-pol2qm74 5497 18 - - HYPH cord-015021-pol2qm74 5497 19 IL6 il6 NN cord-015021-pol2qm74 5497 20 . . . cord-015021-pol2qm74 5498 1 The the DT cord-015021-pol2qm74 5498 2 importance importance NN cord-015021-pol2qm74 5498 3 of of IN cord-015021-pol2qm74 5498 4 transcription transcription NN cord-015021-pol2qm74 5498 5 factors factor NNS cord-015021-pol2qm74 5498 6 as as IN cord-015021-pol2qm74 5498 7 potential potential JJ cord-015021-pol2qm74 5498 8 targets target NNS cord-015021-pol2qm74 5498 9 for for IN cord-015021-pol2qm74 5498 10 novel novel JJ cord-015021-pol2qm74 5498 11 bioactive bioactive JJ cord-015021-pol2qm74 5498 12 substances substance NNS cord-015021-pol2qm74 5498 13 and and CC cord-015021-pol2qm74 5498 14 possibly possibly RB cord-015021-pol2qm74 5498 15 therapeutic therapeutic JJ cord-015021-pol2qm74 5498 16 agents agent NNS cord-015021-pol2qm74 5498 17 will will MD cord-015021-pol2qm74 5498 18 be be VB cord-015021-pol2qm74 5498 19 discussed discuss VBN cord-015021-pol2qm74 5498 20 with with IN cord-015021-pol2qm74 5498 21 the the DT cord-015021-pol2qm74 5498 22 help help NN cord-015021-pol2qm74 5498 23 of of IN cord-015021-pol2qm74 5498 24 several several JJ cord-015021-pol2qm74 5498 25 recent recent JJ cord-015021-pol2qm74 5498 26 examples example NNS cord-015021-pol2qm74 5498 27 . . . cord-015021-pol2qm74 5499 1 New new JJ cord-015021-pol2qm74 5499 2 methods method NNS cord-015021-pol2qm74 5499 3 for for IN cord-015021-pol2qm74 5499 4 altering alter VBG cord-015021-pol2qm74 5499 5 the the DT cord-015021-pol2qm74 5499 6 germ germ NN cord-015021-pol2qm74 5499 7 lines line NNS cord-015021-pol2qm74 5499 8 of of IN cord-015021-pol2qm74 5499 9 mice mouse NNS cord-015021-pol2qm74 5499 10 provide provide VBP cord-015021-pol2qm74 5499 11 powerful powerful JJ cord-015021-pol2qm74 5499 12 tools tool NNS cord-015021-pol2qm74 5499 13 for for IN cord-015021-pol2qm74 5499 14 understanding understand VBG cord-015021-pol2qm74 5499 15 the the DT cord-015021-pol2qm74 5499 16 roles role NNS cord-015021-pol2qm74 5499 17 of of IN cord-015021-pol2qm74 5499 18 individual individual JJ cord-015021-pol2qm74 5499 19 genes gene NNS cord-015021-pol2qm74 5499 20 in in IN cord-015021-pol2qm74 5499 21 normal normal JJ cord-015021-pol2qm74 5499 22 and and CC cord-015021-pol2qm74 5499 23 pathological pathological JJ cord-015021-pol2qm74 5499 24 processes process NNS cord-015021-pol2qm74 5499 25 , , , cord-015021-pol2qm74 5499 26 and and CC cord-015021-pol2qm74 5499 27 for for IN cord-015021-pol2qm74 5499 28 reproducing reproduce VBG cord-015021-pol2qm74 5499 29 specific specific JJ cord-015021-pol2qm74 5499 30 genetic genetic JJ cord-015021-pol2qm74 5499 31 mutations mutation NNS cord-015021-pol2qm74 5499 32 that that WDT cord-015021-pol2qm74 5499 33 result result VBP cord-015021-pol2qm74 5499 34 in in IN cord-015021-pol2qm74 5499 35 congenital congenital JJ cord-015021-pol2qm74 5499 36 disease disease NN cord-015021-pol2qm74 5499 37 . . . cord-015021-pol2qm74 5500 1 Three three CD cord-015021-pol2qm74 5500 2 approaches approach NNS cord-015021-pol2qm74 5500 3 will will MD cord-015021-pol2qm74 5500 4 be be VB cord-015021-pol2qm74 5500 5 discussed discuss VBN cord-015021-pol2qm74 5500 6 . . . cord-015021-pol2qm74 5501 1 Conventional conventional JJ cord-015021-pol2qm74 5501 2 transgeulc transgeulc NN cord-015021-pol2qm74 5501 3 mice mouse NNS cord-015021-pol2qm74 5501 4 are be VBP cord-015021-pol2qm74 5501 5 frequently frequently RB cord-015021-pol2qm74 5501 6 constructed construct VBN cord-015021-pol2qm74 5501 7 using use VBG cord-015021-pol2qm74 5501 8 artificial artificial JJ cord-015021-pol2qm74 5501 9 transgenes transgene NNS cord-015021-pol2qm74 5501 10 that that WDT cord-015021-pol2qm74 5501 11 express express VBP cord-015021-pol2qm74 5501 12 genes gene NNS cord-015021-pol2qm74 5501 13 from from IN cord-015021-pol2qm74 5501 14 a a DT cord-015021-pol2qm74 5501 15 promoter promoter NN cord-015021-pol2qm74 5501 16 other other JJ cord-015021-pol2qm74 5501 17 than than IN cord-015021-pol2qm74 5501 18 the the DT cord-015021-pol2qm74 5501 19 normal normal JJ cord-015021-pol2qm74 5501 20 gene gene NN cord-015021-pol2qm74 5501 21 promoter promoter NN cord-015021-pol2qm74 5501 22 . . . cord-015021-pol2qm74 5502 1 This this DT cord-015021-pol2qm74 5502 2 paradigm paradigm NN cord-015021-pol2qm74 5502 3 is be VBZ cord-015021-pol2qm74 5502 4 used use VBN cord-015021-pol2qm74 5502 5 to to TO cord-015021-pol2qm74 5502 6 produce produce VB cord-015021-pol2qm74 5502 7 very very RB cord-015021-pol2qm74 5502 8 high high JJ cord-015021-pol2qm74 5502 9 levels level NNS cord-015021-pol2qm74 5502 10 of of IN cord-015021-pol2qm74 5502 11 a a DT cord-015021-pol2qm74 5502 12 gene gene NN cord-015021-pol2qm74 5502 13 product product NN cord-015021-pol2qm74 5502 14 , , , cord-015021-pol2qm74 5502 15 for for IN cord-015021-pol2qm74 5502 16 example example NN cord-015021-pol2qm74 5502 17 , , , cord-015021-pol2qm74 5502 18 with with IN cord-015021-pol2qm74 5502 19 a a DT cord-015021-pol2qm74 5502 20 viral viral JJ cord-015021-pol2qm74 5502 21 promoter promoter NN cord-015021-pol2qm74 5502 22 , , , cord-015021-pol2qm74 5502 23 or or CC cord-015021-pol2qm74 5502 24 to to TO cord-015021-pol2qm74 5502 25 attempt attempt VB cord-015021-pol2qm74 5502 26 to to TO cord-015021-pol2qm74 5502 27 regulate regulate VB cord-015021-pol2qm74 5502 28 gene gene NN cord-015021-pol2qm74 5502 29 expression expression NN cord-015021-pol2qm74 5502 30 using use VBG cord-015021-pol2qm74 5502 31 an an DT cord-015021-pol2qm74 5502 32 inducible inducible JJ cord-015021-pol2qm74 5502 33 promoter promoter NN cord-015021-pol2qm74 5502 34 . . . cord-015021-pol2qm74 5503 1 Alternatively alternatively RB cord-015021-pol2qm74 5503 2 , , , cord-015021-pol2qm74 5503 3 normal normal JJ cord-015021-pol2qm74 5503 4 promoter promoter NN cord-015021-pol2qm74 5503 5 sequences sequence NNS cord-015021-pol2qm74 5503 6 can can MD cord-015021-pol2qm74 5503 7 be be VB cord-015021-pol2qm74 5503 8 hooked hook VBN cord-015021-pol2qm74 5503 9 to to IN cord-015021-pol2qm74 5503 10 a a DT cord-015021-pol2qm74 5503 11 gene gene NN cord-015021-pol2qm74 5503 12 whose whose WP$ cord-015021-pol2qm74 5503 13 expression expression NN cord-015021-pol2qm74 5503 14 is be VBZ cord-015021-pol2qm74 5503 15 lethal lethal JJ cord-015021-pol2qm74 5503 16 to to IN cord-015021-pol2qm74 5503 17 the the DT cord-015021-pol2qm74 5503 18 cell cell NN cord-015021-pol2qm74 5503 19 ( ( -LRB- cord-015021-pol2qm74 5503 20 e.g. e.g. RB cord-015021-pol2qm74 5503 21 , , , cord-015021-pol2qm74 5503 22 diptheria diptheria NN cord-015021-pol2qm74 5503 23 toxin toxin NN cord-015021-pol2qm74 5503 24 A a DT cord-015021-pol2qm74 5503 25 chain chain NN cord-015021-pol2qm74 5503 26 ) ) -RRB- cord-015021-pol2qm74 5503 27 to to TO cord-015021-pol2qm74 5503 28 ablate ablate VB cord-015021-pol2qm74 5503 29 all all DT cord-015021-pol2qm74 5503 30 cells cell NNS cord-015021-pol2qm74 5503 31 expressing express VBG cord-015021-pol2qm74 5503 32 that that DT cord-015021-pol2qm74 5503 33 gene gene NN cord-015021-pol2qm74 5503 34 . . . cord-015021-pol2qm74 5504 1 Another another DT cord-015021-pol2qm74 5504 2 approach approach NN cord-015021-pol2qm74 5504 3 uses use VBZ cord-015021-pol2qm74 5504 4 an an DT cord-015021-pol2qm74 5504 5 intact intact JJ cord-015021-pol2qm74 5504 6 gene gene NN cord-015021-pol2qm74 5504 7 with with IN cord-015021-pol2qm74 5504 8 its -PRON- PRP$ cord-015021-pol2qm74 5504 9 normal normal JJ cord-015021-pol2qm74 5504 10 regulatory regulatory JJ cord-015021-pol2qm74 5504 11 sequences sequence NNS cord-015021-pol2qm74 5504 12 . . . cord-015021-pol2qm74 5505 1 Here here RB cord-015021-pol2qm74 5505 2 , , , cord-015021-pol2qm74 5505 3 an an DT cord-015021-pol2qm74 5505 4 elevated elevated JJ cord-015021-pol2qm74 5505 5 level level NN cord-015021-pol2qm74 5505 6 of of IN cord-015021-pol2qm74 5505 7 the the DT cord-015021-pol2qm74 5505 8 gene gene NN cord-015021-pol2qm74 5505 9 product product NN cord-015021-pol2qm74 5505 10 is be VBZ cord-015021-pol2qm74 5505 11 delivered deliver VBN cord-015021-pol2qm74 5505 12 from from IN cord-015021-pol2qm74 5505 13 the the DT cord-015021-pol2qm74 5505 14 correct correct JJ cord-015021-pol2qm74 5505 15 cells cell NNS cord-015021-pol2qm74 5505 16 in in IN cord-015021-pol2qm74 5505 17 the the DT cord-015021-pol2qm74 5505 18 correct correct JJ cord-015021-pol2qm74 5505 19 tissues tissue NNS cord-015021-pol2qm74 5505 20 at at IN cord-015021-pol2qm74 5505 21 the the DT cord-015021-pol2qm74 5505 22 correct correct JJ cord-015021-pol2qm74 5505 23 developmental developmental JJ cord-015021-pol2qm74 5505 24 stages stage NNS cord-015021-pol2qm74 5505 25 or or CC cord-015021-pol2qm74 5505 26 in in IN cord-015021-pol2qm74 5505 27 response response NN cord-015021-pol2qm74 5505 28 to to IN cord-015021-pol2qm74 5505 29 natural natural JJ cord-015021-pol2qm74 5505 30 signals signal NNS cord-015021-pol2qm74 5505 31 . . . cord-015021-pol2qm74 5506 1 This this DT cord-015021-pol2qm74 5506 2 approach approach NN cord-015021-pol2qm74 5506 3 has have VBZ cord-015021-pol2qm74 5506 4 been be VBN cord-015021-pol2qm74 5506 5 refered refer VBN cord-015021-pol2qm74 5506 6 to to IN cord-015021-pol2qm74 5506 7 as as IN cord-015021-pol2qm74 5506 8 " " `` cord-015021-pol2qm74 5506 9 genetic genetic JJ cord-015021-pol2qm74 5506 10 pharmacology pharmacology NN cord-015021-pol2qm74 5506 11 , , , cord-015021-pol2qm74 5506 12 " " '' cord-015021-pol2qm74 5506 13 and and CC cord-015021-pol2qm74 5506 14 provides provide VBZ cord-015021-pol2qm74 5506 15 a a DT cord-015021-pol2qm74 5506 16 precise precise JJ cord-015021-pol2qm74 5506 17 delivery delivery NN cord-015021-pol2qm74 5506 18 of of IN cord-015021-pol2qm74 5506 19 the the DT cord-015021-pol2qm74 5506 20 gene gene NN cord-015021-pol2qm74 5506 21 product product NN cord-015021-pol2qm74 5506 22 to to IN cord-015021-pol2qm74 5506 23 the the DT cord-015021-pol2qm74 5506 24 target target NN cord-015021-pol2qm74 5506 25 . . . cord-015021-pol2qm74 5507 1 However however RB cord-015021-pol2qm74 5507 2 , , , cord-015021-pol2qm74 5507 3 to to TO cord-015021-pol2qm74 5507 4 be be VB cord-015021-pol2qm74 5507 5 most most RBS cord-015021-pol2qm74 5507 6 effective effective JJ cord-015021-pol2qm74 5507 7 , , , cord-015021-pol2qm74 5507 8 the the DT cord-015021-pol2qm74 5507 9 transgene transgene NN cord-015021-pol2qm74 5507 10 should should MD cord-015021-pol2qm74 5507 11 contain contain VB cord-015021-pol2qm74 5507 12 arl arl NNP cord-015021-pol2qm74 5507 13 regulatory regulatory JJ cord-015021-pol2qm74 5507 14 sequences sequence NNS cord-015021-pol2qm74 5507 15 as as IN cord-015021-pol2qm74 5507 16 welt welt NN cord-015021-pol2qm74 5507 17 as as IN cord-015021-pol2qm74 5507 18 the the DT cord-015021-pol2qm74 5507 19 entire entire JJ cord-015021-pol2qm74 5507 20 genomic genomic JJ cord-015021-pol2qm74 5507 21 segment segment NN cord-015021-pol2qm74 5507 22 containing contain VBG cord-015021-pol2qm74 5507 23 gene gene NN cord-015021-pol2qm74 5507 24 coding code VBG cord-015021-pol2qm74 5507 25 regions region NNS cord-015021-pol2qm74 5507 26 . . . cord-015021-pol2qm74 5508 1 The the DT cord-015021-pol2qm74 5508 2 introduction introduction NN cord-015021-pol2qm74 5508 3 of of IN cord-015021-pol2qm74 5508 4 conventional conventional JJ cord-015021-pol2qm74 5508 5 transgenes transgene NNS cord-015021-pol2qm74 5508 6 is be VBZ cord-015021-pol2qm74 5508 7 limited limit VBN cord-015021-pol2qm74 5508 8 to to IN cord-015021-pol2qm74 5508 9 roughly roughly RB cord-015021-pol2qm74 5508 10 50 50 CD cord-015021-pol2qm74 5508 11 kilobases kilobase NNS cord-015021-pol2qm74 5508 12 , , , cord-015021-pol2qm74 5508 13 while while IN cord-015021-pol2qm74 5508 14 genes gene NNS cord-015021-pol2qm74 5508 15 containing contain VBG cord-015021-pol2qm74 5508 16 all all DT cord-015021-pol2qm74 5508 17 regulatory regulatory JJ cord-015021-pol2qm74 5508 18 sequences sequence NNS cord-015021-pol2qm74 5508 19 frequently frequently RB cord-015021-pol2qm74 5508 20 stretch stretch VBP cord-015021-pol2qm74 5508 21 over over IN cord-015021-pol2qm74 5508 22 dozens dozen NNS cord-015021-pol2qm74 5508 23 or or CC cord-015021-pol2qm74 5508 24 even even RB cord-015021-pol2qm74 5508 25 hundreds hundred NNS cord-015021-pol2qm74 5508 26 of of IN cord-015021-pol2qm74 5508 27 kilobases kilobase NNS cord-015021-pol2qm74 5508 28 . . . cord-015021-pol2qm74 5509 1 To to TO cord-015021-pol2qm74 5509 2 overcome overcome VB cord-015021-pol2qm74 5509 3 this this DT cord-015021-pol2qm74 5509 4 problem problem NN cord-015021-pol2qm74 5509 5 , , , cord-015021-pol2qm74 5509 6 procedures procedure NNS cord-015021-pol2qm74 5509 7 have have VBP cord-015021-pol2qm74 5509 8 been be VBN cord-015021-pol2qm74 5509 9 developed develop VBN cord-015021-pol2qm74 5509 10 recently recently RB cord-015021-pol2qm74 5509 11 to to TO cord-015021-pol2qm74 5509 12 introduce introduce VB cord-015021-pol2qm74 5509 13 yeast yeast NN cord-015021-pol2qm74 5509 14 artificial artificial JJ cord-015021-pol2qm74 5509 15 chromosomes chromosome NNS cord-015021-pol2qm74 5509 16 ( ( -LRB- cord-015021-pol2qm74 5509 17 YACs YACs NNP cord-015021-pol2qm74 5509 18 ) ) -RRB- cord-015021-pol2qm74 5509 19 into into IN cord-015021-pol2qm74 5509 20 mouse mouse NN cord-015021-pol2qm74 5509 21 embryonic embryonic JJ cord-015021-pol2qm74 5509 22 stem stem NN cord-015021-pol2qm74 5509 23 ( ( -LRB- cord-015021-pol2qm74 5509 24 ES ES NNP cord-015021-pol2qm74 5509 25 ) ) -RRB- cord-015021-pol2qm74 5509 26 cells cell NNS cord-015021-pol2qm74 5509 27 . . . cord-015021-pol2qm74 5510 1 YACs yac NNS cord-015021-pol2qm74 5510 2 can can MD cord-015021-pol2qm74 5510 3 include include VB cord-015021-pol2qm74 5510 4 over over IN cord-015021-pol2qm74 5510 5 2 2 CD cord-015021-pol2qm74 5510 6 Mb Mb NNS cord-015021-pol2qm74 5510 7 of of IN cord-015021-pol2qm74 5510 8 human human JJ cord-015021-pol2qm74 5510 9 DNA dna NN cord-015021-pol2qm74 5510 10 , , , cord-015021-pol2qm74 5510 11 large large JJ cord-015021-pol2qm74 5510 12 enough enough RB cord-015021-pol2qm74 5510 13 to to TO cord-015021-pol2qm74 5510 14 encompass encompass VB cord-015021-pol2qm74 5510 15 the the DT cord-015021-pol2qm74 5510 16 largest large JJS cord-015021-pol2qm74 5510 17 known know VBN cord-015021-pol2qm74 5510 18 human human JJ cord-015021-pol2qm74 5510 19 genes gene NNS cord-015021-pol2qm74 5510 20 . . . cord-015021-pol2qm74 5511 1 ES ES NNP cord-015021-pol2qm74 5511 2 cells cell NNS cord-015021-pol2qm74 5511 3 are be VBP cord-015021-pol2qm74 5511 4 also also RB cord-015021-pol2qm74 5511 5 useful useful JJ cord-015021-pol2qm74 5511 6 for for IN cord-015021-pol2qm74 5511 7 targeted target VBN cord-015021-pol2qm74 5511 8 gene gene NN cord-015021-pol2qm74 5511 9 deletions deletion NNS cord-015021-pol2qm74 5511 10 and and CC cord-015021-pol2qm74 5511 11 mutations mutation NNS cord-015021-pol2qm74 5511 12 . . . cord-015021-pol2qm74 5512 1 Homologous homologous JJ cord-015021-pol2qm74 5512 2 recombination recombination NN cord-015021-pol2qm74 5512 3 can can MD cord-015021-pol2qm74 5512 4 be be VB cord-015021-pol2qm74 5512 5 targeted target VBN cord-015021-pol2qm74 5512 6 to to IN cord-015021-pol2qm74 5512 7 any any DT cord-015021-pol2qm74 5512 8 known know VBN cord-015021-pol2qm74 5512 9 gene gene NN cord-015021-pol2qm74 5512 10 in in IN cord-015021-pol2qm74 5512 11 ES ES NNP cord-015021-pol2qm74 5512 12 cells cell NNS cord-015021-pol2qm74 5512 13 . . . cord-015021-pol2qm74 5513 1 When when WRB cord-015021-pol2qm74 5513 2 these these DT cord-015021-pol2qm74 5513 3 modified modify VBN cord-015021-pol2qm74 5513 4 cells cell NNS cord-015021-pol2qm74 5513 5 are be VBP cord-015021-pol2qm74 5513 6 injected inject VBN cord-015021-pol2qm74 5513 7 into into IN cord-015021-pol2qm74 5513 8 a a DT cord-015021-pol2qm74 5513 9 mouse mouse NN cord-015021-pol2qm74 5513 10 blastocyst blastocyst NN cord-015021-pol2qm74 5513 11 , , , cord-015021-pol2qm74 5513 12 they -PRON- PRP cord-015021-pol2qm74 5513 13 can can MD cord-015021-pol2qm74 5513 14 be be VB cord-015021-pol2qm74 5513 15 incorporated incorporate VBN cord-015021-pol2qm74 5513 16 into into IN cord-015021-pol2qm74 5513 17 all all DT cord-015021-pol2qm74 5513 18 tissues tissue NNS cord-015021-pol2qm74 5513 19 of of IN cord-015021-pol2qm74 5513 20 the the DT cord-015021-pol2qm74 5513 21 resulting result VBG cord-015021-pol2qm74 5513 22 mouse mouse NN cord-015021-pol2qm74 5513 23 , , , cord-015021-pol2qm74 5513 24 including include VBG cord-015021-pol2qm74 5513 25 germ germ NN cord-015021-pol2qm74 5513 26 cells cell NNS cord-015021-pol2qm74 5513 27 , , , cord-015021-pol2qm74 5513 28 so so IN cord-015021-pol2qm74 5513 29 subsequent subsequent JJ cord-015021-pol2qm74 5513 30 generations generation NNS cord-015021-pol2qm74 5513 31 will will MD cord-015021-pol2qm74 5513 32 pass pass VB cord-015021-pol2qm74 5513 33 the the DT cord-015021-pol2qm74 5513 34 genetic genetic JJ cord-015021-pol2qm74 5513 35 modification modification NN cord-015021-pol2qm74 5513 36 as as IN cord-015021-pol2qm74 5513 37 an an DT cord-015021-pol2qm74 5513 38 inherited inherit VBN cord-015021-pol2qm74 5513 39 trait trait NN cord-015021-pol2qm74 5513 40 . . . cord-015021-pol2qm74 5514 1 Assessment assessment NN cord-015021-pol2qm74 5514 2 of of IN cord-015021-pol2qm74 5514 3 the the DT cord-015021-pol2qm74 5514 4 effects effect NNS cord-015021-pol2qm74 5514 5 of of IN cord-015021-pol2qm74 5514 6 a a DT cord-015021-pol2qm74 5514 7 null null JJ cord-015021-pol2qm74 5514 8 allele allele NN cord-015021-pol2qm74 5514 9 on on IN cord-015021-pol2qm74 5514 10 development development NN cord-015021-pol2qm74 5514 11 can can MD cord-015021-pol2qm74 5514 12 provide provide VB cord-015021-pol2qm74 5514 13 valuable valuable JJ cord-015021-pol2qm74 5514 14 insights insight NNS cord-015021-pol2qm74 5514 15 into into IN cord-015021-pol2qm74 5514 16 its -PRON- PRP$ cord-015021-pol2qm74 5514 17 normal normal JJ cord-015021-pol2qm74 5514 18 role role NN cord-015021-pol2qm74 5514 19 . . . cord-015021-pol2qm74 5515 1 Ultimately ultimately RB cord-015021-pol2qm74 5515 2 , , , cord-015021-pol2qm74 5515 3 these these DT cord-015021-pol2qm74 5515 4 technologies technology NNS cord-015021-pol2qm74 5515 5 may may MD cord-015021-pol2qm74 5515 6 be be VB cord-015021-pol2qm74 5515 7 adapted adapt VBN cord-015021-pol2qm74 5515 8 to to IN cord-015021-pol2qm74 5515 9 human human JJ cord-015021-pol2qm74 5515 10 cells cell NNS cord-015021-pol2qm74 5515 11 -not -not : cord-015021-pol2qm74 5515 12 for for IN cord-015021-pol2qm74 5515 13 embryonic embryonic JJ cord-015021-pol2qm74 5515 14 intervention intervention NN cord-015021-pol2qm74 5515 15 , , , cord-015021-pol2qm74 5515 16 but but CC cord-015021-pol2qm74 5515 17 to to TO cord-015021-pol2qm74 5515 18 provide provide VB cord-015021-pol2qm74 5515 19 modified modify VBN cord-015021-pol2qm74 5515 20 stem stem NN cord-015021-pol2qm74 5515 21 cells cell NNS cord-015021-pol2qm74 5515 22 for for IN cord-015021-pol2qm74 5515 23 various various JJ cord-015021-pol2qm74 5515 24 tissues tissue NNS cord-015021-pol2qm74 5515 25 ( ( -LRB- cord-015021-pol2qm74 5515 26 e.g. e.g. RB cord-015021-pol2qm74 5515 27 , , , cord-015021-pol2qm74 5515 28 gut gut NN cord-015021-pol2qm74 5515 29 , , , cord-015021-pol2qm74 5515 30 eye eye NN cord-015021-pol2qm74 5515 31 , , , cord-015021-pol2qm74 5515 32 hematopoietic hematopoietic JJ cord-015021-pol2qm74 5515 33 system system NN cord-015021-pol2qm74 5515 34 ) ) -RRB- cord-015021-pol2qm74 5515 35 which which WDT cord-015021-pol2qm74 5515 36 could could MD cord-015021-pol2qm74 5515 37 then then RB cord-015021-pol2qm74 5515 38 be be VB cord-015021-pol2qm74 5515 39 applied apply VBN cord-015021-pol2qm74 5515 40 to to IN cord-015021-pol2qm74 5515 41 somatic somatic JJ cord-015021-pol2qm74 5515 42 therapies therapy NNS cord-015021-pol2qm74 5515 43 . . . cord-015021-pol2qm74 5516 1 with with IN cord-015021-pol2qm74 5516 2 major major JJ cord-015021-pol2qm74 5516 3 illness illness NN cord-015021-pol2qm74 5516 4 / / SYM cord-015021-pol2qm74 5516 5 injury injury NN cord-015021-pol2qm74 5516 6 that that WDT cord-015021-pol2qm74 5516 7 respirswy respirswy NNP cord-015021-pol2qm74 5516 8 faihne faihne NNP cord-015021-pol2qm74 5516 9 fi'equently fi'equently NNP cord-015021-pol2qm74 5516 10 followed follow VBD cord-015021-pol2qm74 5516 11 sepsis sepsis NN cord-015021-pol2qm74 5516 12 , , , cord-015021-pol2qm74 5516 13 Tilney Tilney NNP cord-015021-pol2qm74 5516 14 el el NNP cord-015021-pol2qm74 5516 15 al al NNP cord-015021-pol2qm74 5516 16 nse nse NNP cord-015021-pol2qm74 5516 17 , , , cord-015021-pol2qm74 5516 18 d d NNP cord-015021-pol2qm74 5516 19 the the DT cord-015021-pol2qm74 5516 20 term term NN cord-015021-pol2qm74 5516 21 " " `` cord-015021-pol2qm74 5516 22 soqueutial soqueutial JJ cord-015021-pol2qm74 5516 23 syste~ syste~ NN cord-015021-pol2qm74 5516 24 failure failure NN cord-015021-pol2qm74 5516 25 " " '' cord-015021-pol2qm74 5516 26 for for IN cord-015021-pol2qm74 5516 27 patients patient NNS cord-015021-pol2qm74 5516 28 with with IN cord-015021-pol2qm74 5516 29 renal renal JJ cord-015021-pol2qm74 5516 30 failure failure NN cord-015021-pol2qm74 5516 31 after after IN cord-015021-pol2qm74 5516 32 Solmir Solmir NNP cord-015021-pol2qm74 5516 33 of of IN cord-015021-pol2qm74 5516 34 ruptured ruptured JJ cord-015021-pol2qm74 5516 35 abdominal abdominal JJ cord-015021-pol2qm74 5516 36 aortic aortic NN cord-015021-pol2qm74 5517 1 ~aeurysms ~aeurysms . cord-015021-pol2qm74 5518 1 , , , cord-015021-pol2qm74 5518 2 I -PRON- PRP cord-015021-pol2qm74 5518 3 then then RB cord-015021-pol2qm74 5518 4 reviewed review VBD cord-015021-pol2qm74 5518 5 our -PRON- PRP$ cord-015021-pol2qm74 5518 6 experiences experience NNS cord-015021-pol2qm74 5518 7 after after IN cord-015021-pol2qm74 5518 8 inju~ inju~ NN cord-015021-pol2qm74 5518 9 and and CC cord-015021-pol2qm74 5518 10 oporstion oporstion NN cord-015021-pol2qm74 5518 11 and and CC cord-015021-pol2qm74 5518 12 suggested suggest VBD cord-015021-pol2qm74 5518 13 that that IN cord-015021-pol2qm74 5518 14 multiple multiple JJ cord-015021-pol2qm74 5518 15 , , , cord-015021-pol2qm74 5518 16 progsesslve progsesslve JJ cord-015021-pol2qm74 5518 17 or or CC cord-015021-pol2qm74 5518 18 sequential sequential JJ cord-015021-pol2qm74 5518 19 systems system NNS cord-015021-pol2qm74 5518 20 or or CC cord-015021-pol2qm74 5518 21 organ organ NN cord-015021-pol2qm74 5518 22 failure failure NN cord-015021-pol2qm74 5518 23 was be VBD cord-015021-pol2qm74 5518 24 a a DT cord-015021-pol2qm74 5518 25 syndrome syndrome NN cord-015021-pol2qm74 5518 26 to to TO cord-015021-pol2qm74 5518 27 be be VB cord-015021-pol2qm74 5518 28 reckoned reckon VBN cord-015021-pol2qm74 5518 29 with with IN cord-015021-pol2qm74 5518 30 in in IN cord-015021-pol2qm74 5518 31 the the DT cord-015021-pol2qm74 5518 32 , , , cord-015021-pol2qm74 5518 33 70 70 CD cord-015021-pol2qm74 5518 34 's 's POS cord-015021-pol2qm74 5518 35 . . . cord-015021-pol2qm74 5519 1 Eiseman Eiseman NNP cord-015021-pol2qm74 5519 2 et et NNP cord-015021-pol2qm74 5519 3 al al NNP cord-015021-pol2qm74 5519 4 then then RB cord-015021-pol2qm74 5519 5 wrote write VBD cord-015021-pol2qm74 5519 6 about about IN cord-015021-pol2qm74 5519 7 " " `` cord-015021-pol2qm74 5519 8 multiple multiple JJ cord-015021-pol2qm74 5519 9 organ organ NN cord-015021-pol2qm74 5519 10 failure failure NN cord-015021-pol2qm74 5519 11 " " '' cord-015021-pol2qm74 5519 12 , , , cord-015021-pol2qm74 5519 13 especially especially RB cord-015021-pol2qm74 5519 14 with with IN cord-015021-pol2qm74 5519 15 liver liver NN cord-015021-pol2qm74 5519 16 failure failure NN cord-015021-pol2qm74 5519 17 . . . cord-015021-pol2qm74 5520 1 Polk Polk NNP cord-015021-pol2qm74 5520 2 el el NNP cord-015021-pol2qm74 5520 3 M M NNP cord-015021-pol2qm74 5520 4 found find VBD cord-015021-pol2qm74 5520 5 that that IN cord-015021-pol2qm74 5520 6 renmte renmte NNP cord-015021-pol2qm74 5520 7 orgau orgau NNP cord-015021-pol2qm74 5520 8 failure failure NN cord-015021-pol2qm74 5520 9 often often RB cord-015021-pol2qm74 5520 10 signalled signal VBD cord-015021-pol2qm74 5520 11 occult occult JJ cord-015021-pol2qm74 5520 12 anita anita NNP cord-015021-pol2qm74 5520 13 - - HYPH cord-015021-pol2qm74 5520 14 abdominal abdominal JJ cord-015021-pol2qm74 5520 15 infection infection NN cord-015021-pol2qm74 5520 16 . . . cord-015021-pol2qm74 5521 1 Fry Fry NNP cord-015021-pol2qm74 5521 2 et et NNP cord-015021-pol2qm74 5521 3 al al NNP cord-015021-pol2qm74 5521 4 ampbasized ampbasize VBD cord-015021-pol2qm74 5521 5 the the DT cord-015021-pol2qm74 5521 6 role role NN cord-015021-pol2qm74 5521 7 of of IN cord-015021-pol2qm74 5521 8 uncontrolled uncontrolled JJ cord-015021-pol2qm74 5521 9 infection infection NN cord-015021-pol2qm74 5521 10 in in IN cord-015021-pol2qm74 5521 11 organ organ NN cord-015021-pol2qm74 5521 12 failure failure NN cord-015021-pol2qm74 5521 13 , , , cord-015021-pol2qm74 5521 14 Border Border NNP cord-015021-pol2qm74 5521 15 et et NNP cord-015021-pol2qm74 5521 16 aI aI NNP cord-015021-pol2qm74 5521 17 described describe VBD cord-015021-pol2qm74 5521 18 metabolic metabolic JJ cord-015021-pol2qm74 5521 19 alterations alteration NNS cord-015021-pol2qm74 5521 20 with with IN cord-015021-pol2qm74 5521 21 MOF MOF NNP cord-015021-pol2qm74 5521 22 and and CC cord-015021-pol2qm74 5521 23 used use VBD cord-015021-pol2qm74 5521 24 the the DT cord-015021-pol2qm74 5521 25 term term NN cord-015021-pol2qm74 5521 26 multiplesystems multiplesystem NNS cord-015021-pol2qm74 5521 27 organ organ NN cord-015021-pol2qm74 5521 28 feilmo feilmo NNP cord-015021-pol2qm74 5521 29 ( ( -LRB- cord-015021-pol2qm74 5521 30 MSOF MSOF NNP cord-015021-pol2qm74 5521 31 ) ) -RRB- cord-015021-pol2qm74 5521 32 . . . cord-015021-pol2qm74 5522 1 Other other JJ cord-015021-pol2qm74 5522 2 early early JJ cord-015021-pol2qm74 5522 3 conltibutots conltibutot NNS cord-015021-pol2qm74 5522 4 to to IN cord-015021-pol2qm74 5522 5 our -PRON- PRP$ cord-015021-pol2qm74 5522 6 knowledge knowledge NN cord-015021-pol2qm74 5522 7 of of IN cord-015021-pol2qm74 5522 8 MOF MOF NNP cord-015021-pol2qm74 5522 9 include include VBP cord-015021-pol2qm74 5522 10 Faist Faist NNP cord-015021-pol2qm74 5522 11 , , , cord-015021-pol2qm74 5522 12 Trunkey Trunkey NNP cord-015021-pol2qm74 5522 13 and and CC cord-015021-pol2qm74 5522 14 Miller Miller NNP cord-015021-pol2qm74 5522 15 , , , cord-015021-pol2qm74 5522 16 Marshall Marshall NNP cord-015021-pol2qm74 5522 17 and and CC cord-015021-pol2qm74 5522 18 Dimic Dimic NNP cord-015021-pol2qm74 5522 19 & & CC cord-015021-pol2qm74 5522 20 , , , cord-015021-pol2qm74 5522 21 Cassone Cassone NNP cord-015021-pol2qm74 5522 22 , , , cord-015021-pol2qm74 5522 23 Catlleo Catlleo NNP cord-015021-pol2qm74 5522 24 , , , cord-015021-pol2qm74 5522 25 Meakins Meakins NNP cord-015021-pol2qm74 5522 26 and and CC cord-015021-pol2qm74 5522 27 Marshall Marshall NNP cord-015021-pol2qm74 5522 28 , , , cord-015021-pol2qm74 5522 29 ( ( -LRB- cord-015021-pol2qm74 5522 30 } } -RRB- cord-015021-pol2qm74 5522 31 otis otis NNP cord-015021-pol2qm74 5522 32 et et NNP cord-015021-pol2qm74 5522 33 at at IN cord-015021-pol2qm74 5522 34 . . . cord-015021-pol2qm74 5523 1 , , , cord-015021-pol2qm74 5523 2 Mater mater NN cord-015021-pol2qm74 5523 3 and and CC cord-015021-pol2qm74 5523 4 many many JJ cord-015021-pol2qm74 5523 5 others other NNS cord-015021-pol2qm74 5523 6 . . . cord-015021-pol2qm74 5524 1 MOF MOF NNP cord-015021-pol2qm74 5524 2 or or CC cord-015021-pol2qm74 5524 3 MSOF MSOF NNP cord-015021-pol2qm74 5524 4 were be VBD cord-015021-pol2qm74 5524 5 used use VBN cord-015021-pol2qm74 5524 6 eommoifly eommoifly NN cord-015021-pol2qm74 5524 7 . . . cord-015021-pol2qm74 5525 1 Cerra Cerra NNP cord-015021-pol2qm74 5525 2 coined coin VBD cord-015021-pol2qm74 5525 3 the the DT cord-015021-pol2qm74 5525 4 terms term NNS cord-015021-pol2qm74 5525 5 " " `` cord-015021-pol2qm74 5525 6 post post JJ cord-015021-pol2qm74 5525 7 - - JJ cord-015021-pol2qm74 5525 8 trsumatic trsumatic JJ cord-015021-pol2qm74 5525 9 septic septic NN cord-015021-pol2qm74 5525 10 sFndromc sFndromc NNP cord-015021-pol2qm74 5525 11 " " '' cord-015021-pol2qm74 5525 12 and and CC cord-015021-pol2qm74 5525 13 " " `` cord-015021-pol2qm74 5525 14 hyper hyper JJ cord-015021-pol2qm74 5525 15 metabolism metabolism NN cord-015021-pol2qm74 5525 16 otgau otgau NN cord-015021-pol2qm74 5525 17 failure failure NN cord-015021-pol2qm74 5525 18 complex complex JJ cord-015021-pol2qm74 5525 19 " " '' cord-015021-pol2qm74 5525 20 , , , cord-015021-pol2qm74 5525 21 and and CC cord-015021-pol2qm74 5525 22 Border Border NNP cord-015021-pol2qm74 5525 23 et et NNP cord-015021-pol2qm74 5525 24 al al NNP cord-015021-pol2qm74 5525 25 , , , cord-015021-pol2qm74 5525 26 used use VBD cord-015021-pol2qm74 5525 27 lhe lhe NNP cord-015021-pol2qm74 5525 28 ex3~ression ex3~ression NN cord-015021-pol2qm74 5525 29 " " `` cord-015021-pol2qm74 5525 30 gut gut VB cord-015021-pol2qm74 5525 31 origin origin NNP cord-015021-pol2qm74 5525 32 seplic seplic NNP cord-015021-pol2qm74 5525 33 states state NNS cord-015021-pol2qm74 5525 34 " " '' cord-015021-pol2qm74 5525 35 to to TO cord-015021-pol2qm74 5525 36 illdioate illdioate VB cord-015021-pol2qm74 5525 37 important important JJ cord-015021-pol2qm74 5525 38 eurrem eurrem NNP cord-015021-pol2qm74 5525 39 aspects aspect NNS cord-015021-pol2qm74 5525 40 of of IN cord-015021-pol2qm74 5525 41 abe abe NNP cord-015021-pol2qm74 5525 42 gt gt NNP cord-015021-pol2qm74 5525 43 . . . cord-015021-pol2qm74 5526 1 ' ' `` cord-015021-pol2qm74 5526 2 nerlc nerlc NNP cord-015021-pol2qm74 5526 3 problem problem NN cord-015021-pol2qm74 5526 4 of of IN cord-015021-pol2qm74 5526 5 organ organ NN cord-015021-pol2qm74 5526 6 failure failure NN cord-015021-pol2qm74 5526 7 and and CC cord-015021-pol2qm74 5526 8 death death NN cord-015021-pol2qm74 5527 1 , , , cord-015021-pol2qm74 5527 2 Other other JJ cord-015021-pol2qm74 5527 3 terms term NNS cord-015021-pol2qm74 5527 4 include include VBP cord-015021-pol2qm74 5527 5 acute acute JJ cord-015021-pol2qm74 5527 6 organ organ NN cord-015021-pol2qm74 5527 7 - - HYPH cord-015021-pol2qm74 5527 8 system system NN cord-015021-pol2qm74 5527 9 failure failure NN cord-015021-pol2qm74 5527 10 , , , cord-015021-pol2qm74 5527 11 multiple multiple JJ cord-015021-pol2qm74 5527 12 organ organ NN cord-015021-pol2qm74 5527 13 injury injury NN cord-015021-pol2qm74 5527 14 syndrome syndrome NN cord-015021-pol2qm74 5527 15 , , , cord-015021-pol2qm74 5527 16 post post JJ cord-015021-pol2qm74 5527 17 - - JJ cord-015021-pol2qm74 5527 18 traumatic traumatic JJ cord-015021-pol2qm74 5527 19 multi multi JJ cord-015021-pol2qm74 5527 20 - - JJ cord-015021-pol2qm74 5527 21 system system JJ cord-015021-pol2qm74 5527 22 organ organ NN cord-015021-pol2qm74 5527 23 failure failure NN cord-015021-pol2qm74 5527 24 nod nod CC cord-015021-pol2qm74 5527 25 post-~aumatic post-~aumatic JJ cord-015021-pol2qm74 5527 26 organ organ NN cord-015021-pol2qm74 5527 27 system system NN cord-015021-pol2qm74 5527 28 infection infection NN cord-015021-pol2qm74 5527 29 s s NNP cord-015021-pol2qm74 5527 30 ~ ~ NFP cord-015021-pol2qm74 5527 31 dmmc dmmc NNP cord-015021-pol2qm74 5527 32 ( ( -LRB- cord-015021-pol2qm74 5527 33 FI FI NNP cord-015021-pol2qm74 5527 34 ~ ~ NFP cord-015021-pol2qm74 5527 35 SIS SIS NNP cord-015021-pol2qm74 5527 36 ) ) -RRB- cord-015021-pol2qm74 5527 37 , , , cord-015021-pol2qm74 5527 38 I -PRON- PRP cord-015021-pol2qm74 5527 39 bdieve bdieve VBP cord-015021-pol2qm74 5527 40 the the DT cord-015021-pol2qm74 5527 41 latin latin NNP cord-015021-pol2qm74 5527 42 " " `` cord-015021-pol2qm74 5527 43 maltiple maltiple JJ cord-015021-pol2qm74 5527 44 organ organ NN cord-015021-pol2qm74 5527 45 failure failure NN cord-015021-pol2qm74 5527 46 " " '' cord-015021-pol2qm74 5527 47 is be VBZ cord-015021-pol2qm74 5527 48 clean clean JJ cord-015021-pol2qm74 5527 49 , , , cord-015021-pol2qm74 5527 50 neat neat JJ cord-015021-pol2qm74 5527 51 and and CC cord-015021-pol2qm74 5527 52 says say VBZ cord-015021-pol2qm74 5527 53 it -PRON- PRP cord-015021-pol2qm74 5527 54 all all DT cord-015021-pol2qm74 5527 55 , , , cord-015021-pol2qm74 5527 56 Now now RB cord-015021-pol2qm74 5527 57 there there EX cord-015021-pol2qm74 5527 58 is be VBZ cord-015021-pol2qm74 5527 59 a a DT cord-015021-pol2qm74 5527 60 proposal proposal NN cord-015021-pol2qm74 5527 61 for for IN cord-015021-pol2qm74 5527 62 a a DT cord-015021-pol2qm74 5527 63 new new JJ cord-015021-pol2qm74 5527 64 set set NN cord-015021-pol2qm74 5527 65 of of IN cord-015021-pol2qm74 5527 66 torminolugios torminolugios NNP cord-015021-pol2qm74 5527 67 -MODS -MODS NNP cord-015021-pol2qm74 5527 68 and and CC cord-015021-pol2qm74 5527 69 SIRS SIRS NNP cord-015021-pol2qm74 5527 70 . . . cord-015021-pol2qm74 5528 1 Will Will MD cord-015021-pol2qm74 5528 2 they -PRON- PRP cord-015021-pol2qm74 5528 3 be be VB cord-015021-pol2qm74 5528 4 helpful helpful JJ cord-015021-pol2qm74 5528 5 in in IN cord-015021-pol2qm74 5528 6 the the DT cord-015021-pol2qm74 5528 7 study study NN cord-015021-pol2qm74 5528 8 and and CC cord-015021-pol2qm74 5528 9 esro esro NNS cord-015021-pol2qm74 5528 10 of of IN cord-015021-pol2qm74 5528 11 patients patient NNS cord-015021-pol2qm74 5528 12 ? ? . cord-015021-pol2qm74 5529 1 Our -PRON- PRP$ cord-015021-pol2qm74 5529 2 speakers speaker NNS cord-015021-pol2qm74 5529 3 in in IN cord-015021-pol2qm74 5529 4 this this DT cord-015021-pol2qm74 5529 5 session session NN cord-015021-pol2qm74 5529 6 will will MD cord-015021-pol2qm74 5529 7 review review VB cord-015021-pol2qm74 5529 8 thcsa thcsa NNP cord-015021-pol2qm74 5529 9 proposals proposal NNS cord-015021-pol2qm74 5529 10 and and CC cord-015021-pol2qm74 5529 11 the the DT cord-015021-pol2qm74 5529 12 evidence evidence NN cord-015021-pol2qm74 5529 13 as as IN cord-015021-pol2qm74 5529 14 we -PRON- PRP cord-015021-pol2qm74 5529 15 strlVO strlVO NNP cord-015021-pol2qm74 5529 16 for for IN cord-015021-pol2qm74 5529 17 eoasensns eoasensns NN cord-015021-pol2qm74 5529 18 . . . cord-015021-pol2qm74 5530 1 It -PRON- PRP cord-015021-pol2qm74 5530 2 has have VBZ cord-015021-pol2qm74 5530 3 been be VBN cord-015021-pol2qm74 5530 4 well well RB cord-015021-pol2qm74 5530 5 demonstrated demonstrate VBN cord-015021-pol2qm74 5530 6 that that IN cord-015021-pol2qm74 5530 7 the the DT cord-015021-pol2qm74 5530 8 administration administration NN cord-015021-pol2qm74 5530 9 of of IN cord-015021-pol2qm74 5530 10 pro pro JJ cord-015021-pol2qm74 5530 11 - - JJ cord-015021-pol2qm74 5530 12 inflammatory inflammatory JJ cord-015021-pol2qm74 5530 13 cytokines cytokine NNS cord-015021-pol2qm74 5530 14 , , , cord-015021-pol2qm74 5530 15 and and CC cord-015021-pol2qm74 5530 16 especially especially RB cord-015021-pol2qm74 5530 17 tumor tumor NN cord-015021-pol2qm74 5530 18 necrosis necrosis NN cord-015021-pol2qm74 5530 19 factor factor NN cord-015021-pol2qm74 5530 20 ( ( -LRB- cord-015021-pol2qm74 5530 21 TNF TNF NNP cord-015021-pol2qm74 5530 22 ) ) -RRB- cord-015021-pol2qm74 5530 23 can can MD cord-015021-pol2qm74 5530 24 result result VB cord-015021-pol2qm74 5530 25 in in IN cord-015021-pol2qm74 5530 26 a a DT cord-015021-pol2qm74 5530 27 picture picture NN cord-015021-pol2qm74 5530 28 similar similar JJ cord-015021-pol2qm74 5530 29 to to IN cord-015021-pol2qm74 5530 30 septic septic JJ cord-015021-pol2qm74 5530 31 shock shock NN cord-015021-pol2qm74 5530 32 with with IN cord-015021-pol2qm74 5530 33 secondary secondary JJ cord-015021-pol2qm74 5530 34 multiple multiple JJ cord-015021-pol2qm74 5530 35 organ organ NN cord-015021-pol2qm74 5530 36 failure failure NN cord-015021-pol2qm74 5530 37 . . . cord-015021-pol2qm74 5531 1 It -PRON- PRP cord-015021-pol2qm74 5531 2 is be VBZ cord-015021-pol2qm74 5531 3 also also RB cord-015021-pol2qm74 5531 4 clear clear JJ cord-015021-pol2qm74 5531 5 that that IN cord-015021-pol2qm74 5531 6 tissue tissue NN cord-015021-pol2qm74 5531 7 hypoxia hypoxia NN cord-015021-pol2qm74 5531 8 can can MD cord-015021-pol2qm74 5531 9 lead lead VB cord-015021-pol2qm74 5531 10 to to IN cord-015021-pol2qm74 5531 11 organ organ NN cord-015021-pol2qm74 5531 12 damage damage NN cord-015021-pol2qm74 5531 13 . . . cord-015021-pol2qm74 5532 1 We -PRON- PRP cord-015021-pol2qm74 5532 2 believe believe VBP cord-015021-pol2qm74 5532 3 that that IN cord-015021-pol2qm74 5532 4 it -PRON- PRP cord-015021-pol2qm74 5532 5 is be VBZ cord-015021-pol2qm74 5532 6 the the DT cord-015021-pol2qm74 5532 7 interaction interaction NN cord-015021-pol2qm74 5532 8 between between IN cord-015021-pol2qm74 5532 9 the the DT cord-015021-pol2qm74 5532 10 two two CD cord-015021-pol2qm74 5532 11 phenomenons phenomenon NNS cord-015021-pol2qm74 5532 12 that that WDT cord-015021-pol2qm74 5532 13 can can MD cord-015021-pol2qm74 5532 14 lead lead VB cord-015021-pol2qm74 5532 15 to to IN cord-015021-pol2qm74 5532 16 MOF MOF NNP cord-015021-pol2qm74 5532 17 . . . cord-015021-pol2qm74 5533 1 On on IN cord-015021-pol2qm74 5533 2 the the DT cord-015021-pol2qm74 5533 3 one one CD cord-015021-pol2qm74 5533 4 hand hand NN cord-015021-pol2qm74 5533 5 , , , cord-015021-pol2qm74 5533 6 the the DT cord-015021-pol2qm74 5533 7 inflammatory inflammatory JJ cord-015021-pol2qm74 5533 8 response response NN cord-015021-pol2qm74 5533 9 is be VBZ cord-015021-pol2qm74 5533 10 amplified amplify VBN cord-015021-pol2qm74 5533 11 in in IN cord-015021-pol2qm74 5533 12 the the DT cord-015021-pol2qm74 5533 13 presence presence NN cord-015021-pol2qm74 5533 14 of of IN cord-015021-pol2qm74 5533 15 hypoxia hypoxia NN cord-015021-pol2qm74 5533 16 . . . cord-015021-pol2qm74 5534 1 On on IN cord-015021-pol2qm74 5534 2 the the DT cord-015021-pol2qm74 5534 3 other other JJ cord-015021-pol2qm74 5534 4 hand hand NN cord-015021-pol2qm74 5534 5 , , , cord-015021-pol2qm74 5534 6 the the DT cord-015021-pol2qm74 5534 7 release release NN cord-015021-pol2qm74 5534 8 of of IN cord-015021-pol2qm74 5534 9 the the DT cord-015021-pol2qm74 5534 10 mediators mediator NNS cord-015021-pol2qm74 5534 11 of of IN cord-015021-pol2qm74 5534 12 sepsis sepsis NN cord-015021-pol2qm74 5534 13 can can MD cord-015021-pol2qm74 5534 14 increase increase VB cord-015021-pol2qm74 5534 15 tbe tbe JJ cord-015021-pol2qm74 5534 16 oxygen oxygen NN cord-015021-pol2qm74 5534 17 demand demand NN cord-015021-pol2qm74 5534 18 ef ef NNP cord-015021-pol2qm74 5534 19 the the DT cord-015021-pol2qm74 5534 20 tissues tissue NNS cord-015021-pol2qm74 5534 21 , , , cord-015021-pol2qm74 5534 22 alter alter VB cord-015021-pol2qm74 5534 23 their -PRON- PRP$ cord-015021-pol2qm74 5534 24 oxygen oxygen NN cord-015021-pol2qm74 5534 25 extraction extraction NN cord-015021-pol2qm74 5534 26 and and CC cord-015021-pol2qm74 5534 27 decrease decrease VB cord-015021-pol2qm74 5534 28 myocardial myocardial JJ cord-015021-pol2qm74 5534 29 contractility contractility NN cord-015021-pol2qm74 5534 30 , , , cord-015021-pol2qm74 5534 31 and and CC cord-015021-pol2qm74 5534 32 the the DT cord-015021-pol2qm74 5534 33 combination combination NN cord-015021-pol2qm74 5534 34 of of IN cord-015021-pol2qm74 5534 35 these these DT cord-015021-pol2qm74 5534 36 elements element NNS cord-015021-pol2qm74 5534 37 accounts account VBZ cord-015021-pol2qm74 5534 38 for for IN cord-015021-pol2qm74 5534 39 the the DT cord-015021-pol2qm74 5534 40 development development NN cord-015021-pol2qm74 5534 41 of of IN cord-015021-pol2qm74 5534 42 septic septic JJ cord-015021-pol2qm74 5534 43 shock shock NN cord-015021-pol2qm74 5534 44 . . . cord-015021-pol2qm74 5535 1 This this DT cord-015021-pol2qm74 5535 2 hypothesis hypothesis NN cord-015021-pol2qm74 5535 3 is be VBZ cord-015021-pol2qm74 5535 4 supported support VBN cord-015021-pol2qm74 5535 5 by by IN cord-015021-pol2qm74 5535 6 two two CD cord-015021-pol2qm74 5535 7 lines line NNS cord-015021-pol2qm74 5535 8 of of IN cord-015021-pol2qm74 5535 9 evidence evidence NN cord-015021-pol2qm74 5535 10 . . . cord-015021-pol2qm74 5536 1 First first RB cord-015021-pol2qm74 5536 2 , , , cord-015021-pol2qm74 5536 3 MOF MOF NNP cord-015021-pol2qm74 5536 4 is be VBZ cord-015021-pol2qm74 5536 5 usually usually RB cord-015021-pol2qm74 5536 6 preceded precede VBN cord-015021-pol2qm74 5536 7 by by IN cord-015021-pol2qm74 5536 8 an an DT cord-015021-pol2qm74 5536 9 episode episode NN cord-015021-pol2qm74 5536 10 of of IN cord-015021-pol2qm74 5536 11 acute acute JJ cord-015021-pol2qm74 5536 12 circulatory circulatory JJ cord-015021-pol2qm74 5536 13 failure failure NN cord-015021-pol2qm74 5536 14 ( ( -LRB- cord-015021-pol2qm74 5536 15 even even RB cord-015021-pol2qm74 5536 16 though though IN cord-015021-pol2qm74 5536 17 frank frank JJ cord-015021-pol2qm74 5536 18 circulatory circulatory JJ cord-015021-pol2qm74 5536 19 shock shock NN cord-015021-pol2qm74 5536 20 may may MD cord-015021-pol2qm74 5536 21 not not RB cord-015021-pol2qm74 5536 22 be be VB cord-015021-pol2qm74 5536 23 evident evident JJ cord-015021-pol2qm74 5536 24 ) ) -RRB- cord-015021-pol2qm74 5536 25 . . . cord-015021-pol2qm74 5537 1 Second second RB cord-015021-pol2qm74 5537 2 , , , cord-015021-pol2qm74 5537 3 recent recent JJ cord-015021-pol2qm74 5537 4 experimental experimental JJ cord-015021-pol2qm74 5537 5 and and CC cord-015021-pol2qm74 5537 6 clinical clinical JJ cord-015021-pol2qm74 5537 7 studies study NNS cord-015021-pol2qm74 5537 8 indicated indicate VBD cord-015021-pol2qm74 5537 9 that that IN cord-015021-pol2qm74 5537 10 immunotherapy immunotherapy NN cord-015021-pol2qm74 5537 11 ( ( -LRB- cord-015021-pol2qm74 5537 12 especially especially RB cord-015021-pol2qm74 5537 13 antibodies antibody NNS cord-015021-pol2qm74 5537 14 to to IN cord-015021-pol2qm74 5537 15 TNF TNF NNP cord-015021-pol2qm74 5537 16 ) ) -RRB- cord-015021-pol2qm74 5537 17 is be VBZ cord-015021-pol2qm74 5537 18 particularly particularly RB cord-015021-pol2qm74 5537 19 effective effective JJ cord-015021-pol2qm74 5537 20 in in IN cord-015021-pol2qm74 5537 21 the the DT cord-015021-pol2qm74 5537 22 most most RBS cord-015021-pol2qm74 5537 23 severe severe JJ cord-015021-pol2qm74 5537 24 forms form NNS cord-015021-pol2qm74 5537 25 of of IN cord-015021-pol2qm74 5537 26 sepsis sepsis NN cord-015021-pol2qm74 5537 27 , , , cord-015021-pol2qm74 5537 28 associated associate VBN cord-015021-pol2qm74 5537 29 with with IN cord-015021-pol2qm74 5537 30 circulatory circulatory JJ cord-015021-pol2qm74 5537 31 shock shock NN cord-015021-pol2qm74 5537 32 . . . cord-015021-pol2qm74 5538 1 Hence hence RB cord-015021-pol2qm74 5538 2 , , , cord-015021-pol2qm74 5538 3 an an DT cord-015021-pol2qm74 5538 4 effective effective JJ cord-015021-pol2qm74 5538 5 way way NN cord-015021-pol2qm74 5538 6 to to TO cord-015021-pol2qm74 5538 7 prevent prevent VB cord-015021-pol2qm74 5538 8 MOF MOF NNP cord-015021-pol2qm74 5538 9 may may MD cord-015021-pol2qm74 5538 10 be be VB cord-015021-pol2qm74 5538 11 a a DT cord-015021-pol2qm74 5538 12 combination combination NN cord-015021-pol2qm74 5538 13 of of IN cord-015021-pol2qm74 5538 14 aggressive aggressive JJ cord-015021-pol2qm74 5538 15 cardiovascular cardiovascular JJ cord-015021-pol2qm74 5538 16 management management NN cord-015021-pol2qm74 5538 17 and and CC cord-015021-pol2qm74 5538 18 immunotherapy immunotherapy NN cord-015021-pol2qm74 5538 19 . . . cord-015021-pol2qm74 5539 1 Development development NN cord-015021-pol2qm74 5539 2 of of IN cord-015021-pol2qm74 5539 3 the the DT cord-015021-pol2qm74 5539 4 multiple multiple JJ cord-015021-pol2qm74 5539 5 organ organ NN cord-015021-pol2qm74 5539 6 dysfunction dysfunction NN cord-015021-pol2qm74 5539 7 syndrome syndrome NN cord-015021-pol2qm74 5539 8 ( ( -LRB- cord-015021-pol2qm74 5539 9 MODS MODS NNP cord-015021-pol2qm74 5539 10 ) ) -RRB- cord-015021-pol2qm74 5539 11 in in IN cord-015021-pol2qm74 5539 12 the the DT cord-015021-pol2qm74 5539 13 critically critically RB cord-015021-pol2qm74 5539 14 ill ill JJ cord-015021-pol2qm74 5539 15 follows follow VBZ cord-015021-pol2qm74 5539 16 an an DT cord-015021-pol2qm74 5539 17 heterogeneous heterogeneous JJ cord-015021-pol2qm74 5539 18 group group NN cord-015021-pol2qm74 5539 19 of of IN cord-015021-pol2qm74 5539 20 stimuli stimulus NNS cord-015021-pol2qm74 5539 21 including include VBG cord-015021-pol2qm74 5539 22 infection infection NN cord-015021-pol2qm74 5539 23 , , , cord-015021-pol2qm74 5539 24 sterile sterile JJ cord-015021-pol2qm74 5539 25 inflammmion inflammmion NN cord-015021-pol2qm74 5539 26 , , , cord-015021-pol2qm74 5539 27 extensive extensive JJ cord-015021-pol2qm74 5539 28 tissue tissue NN cord-015021-pol2qm74 5539 29 injury injury NN cord-015021-pol2qm74 5539 30 , , , cord-015021-pol2qm74 5539 31 ischemia ischemia NN cord-015021-pol2qm74 5539 32 , , , cord-015021-pol2qm74 5539 33 intoxication intoxication NN cord-015021-pol2qm74 5539 34 with with IN cord-015021-pol2qm74 5539 35 a a DT cord-015021-pol2qm74 5539 36 variety variety NN cord-015021-pol2qm74 5539 37 of of IN cord-015021-pol2qm74 5539 38 substances substance NNS cord-015021-pol2qm74 5539 39 , , , cord-015021-pol2qm74 5539 40 and and CC cord-015021-pol2qm74 5539 41 immune immune JJ cord-015021-pol2qm74 5539 42 system system NN cord-015021-pol2qm74 5539 43 activation activation NN cord-015021-pol2qm74 5539 44 . . . cord-015021-pol2qm74 5540 1 Whether whether IN cord-015021-pol2qm74 5540 2 the the DT cord-015021-pol2qm74 5540 3 resulting result VBG cord-015021-pol2qm74 5540 4 physiologic physiologic JJ cord-015021-pol2qm74 5540 5 abnormalities abnormality NNS cord-015021-pol2qm74 5540 6 reflect reflect VBP cord-015021-pol2qm74 5540 7 a a DT cord-015021-pol2qm74 5540 8 common common JJ cord-015021-pol2qm74 5540 9 pathologic pathologic JJ cord-015021-pol2qm74 5540 10 process process NN cord-015021-pol2qm74 5540 11 , , , cord-015021-pol2qm74 5540 12 or or CC cord-015021-pol2qm74 5540 13 are be VBP cord-015021-pol2qm74 5540 14 simply simply RB cord-015021-pol2qm74 5540 15 a a DT cord-015021-pol2qm74 5540 16 non non JJ cord-015021-pol2qm74 5540 17 - - JJ cord-015021-pol2qm74 5540 18 specific specific JJ cord-015021-pol2qm74 5540 19 manifestation manifestation NN cord-015021-pol2qm74 5540 20 of of IN cord-015021-pol2qm74 5540 21 tissue tissue NN cord-015021-pol2qm74 5540 22 injury injury NN cord-015021-pol2qm74 5540 23 is be VBZ cord-015021-pol2qm74 5540 24 unknown unknown JJ cord-015021-pol2qm74 5540 25 . . . cord-015021-pol2qm74 5541 1 Moreover moreover RB cord-015021-pol2qm74 5541 2 , , , cord-015021-pol2qm74 5541 3 the the DT cord-015021-pol2qm74 5541 4 lack lack NN cord-015021-pol2qm74 5541 5 of of IN cord-015021-pol2qm74 5541 6 clearly clearly RB cord-015021-pol2qm74 5541 7 - - HYPH cord-015021-pol2qm74 5541 8 defined define VBN cord-015021-pol2qm74 5541 9 functional functional JJ cord-015021-pol2qm74 5541 10 criteria criterion NNS cord-015021-pol2qm74 5541 11 for for IN cord-015021-pol2qm74 5541 12 the the DT cord-015021-pol2qm74 5541 13 characterization characterization NN cord-015021-pol2qm74 5541 14 of of IN cord-015021-pol2qm74 5541 15 the the DT cord-015021-pol2qm74 5541 16 syndrome syndrome NN cord-015021-pol2qm74 5541 17 on on IN cord-015021-pol2qm74 5541 18 the the DT cord-015021-pol2qm74 5541 19 one one CD cord-015021-pol2qm74 5541 20 hand hand NN cord-015021-pol2qm74 5541 21 , , , cord-015021-pol2qm74 5541 22 and and CC cord-015021-pol2qm74 5541 23 of of IN cord-015021-pol2qm74 5541 24 reliable reliable JJ cord-015021-pol2qm74 5541 25 biochemical biochemical JJ cord-015021-pol2qm74 5541 26 markers marker NNS cord-015021-pol2qm74 5541 27 of of IN cord-015021-pol2qm74 5541 28 its -PRON- PRP$ cord-015021-pol2qm74 5541 29 evolution evolution NN cord-015021-pol2qm74 5541 30 on on IN cord-015021-pol2qm74 5541 31 the the DT cord-015021-pol2qm74 5541 32 other other JJ cord-015021-pol2qm74 5541 33 , , , cord-015021-pol2qm74 5541 34 has have VBZ cord-015021-pol2qm74 5541 35 made make VBN cord-015021-pol2qm74 5541 36 attempts attempt NNS cord-015021-pol2qm74 5541 37 to to TO cord-015021-pol2qm74 5541 38 define define VB cord-015021-pol2qm74 5541 39 its -PRON- PRP$ cord-015021-pol2qm74 5541 40 epidemiology epidemiology NN cord-015021-pol2qm74 5541 41 and and CC cord-015021-pol2qm74 5541 42 natural natural JJ cord-015021-pol2qm74 5541 43 history history NN cord-015021-pol2qm74 5541 44 difficult difficult JJ cord-015021-pol2qm74 5541 45 . . . cord-015021-pol2qm74 5542 1 Using use VBG cord-015021-pol2qm74 5542 2 a a DT cord-015021-pol2qm74 5542 3 numeric numeric JJ cord-015021-pol2qm74 5542 4 scoring scoring NN cord-015021-pol2qm74 5542 5 system system NN cord-015021-pol2qm74 5542 6 to to TO cord-015021-pol2qm74 5542 7 quanfimte quanfimte VB cord-015021-pol2qm74 5542 8 the the DT cord-015021-pol2qm74 5542 9 clinical clinical JJ cord-015021-pol2qm74 5542 10 severity severity NN cord-015021-pol2qm74 5542 11 of of IN cord-015021-pol2qm74 5542 12 MODS mods NN cord-015021-pol2qm74 5542 13 , , , cord-015021-pol2qm74 5542 14 we -PRON- PRP cord-015021-pol2qm74 5542 15 demonstrated demonstrate VBD cord-015021-pol2qm74 5542 16 that that IN cord-015021-pol2qm74 5542 17 , , , cord-015021-pol2qm74 5542 18 although although IN cord-015021-pol2qm74 5542 19 MODS MODS NNP cord-015021-pol2qm74 5542 20 is be VBZ cord-015021-pol2qm74 5542 21 more more RBR cord-015021-pol2qm74 5542 22 common common JJ cord-015021-pol2qm74 5542 23 in in IN cord-015021-pol2qm74 5542 24 patients patient NNS cord-015021-pol2qm74 5542 25 who who WP cord-015021-pol2qm74 5542 26 have have VBP cord-015021-pol2qm74 5542 27 significant significant JJ cord-015021-pol2qm74 5542 28 infection infection NN cord-015021-pol2qm74 5542 29 at at IN cord-015021-pol2qm74 5542 30 the the DT cord-015021-pol2qm74 5542 31 time time NN cord-015021-pol2qm74 5542 32 of of IN cord-015021-pol2qm74 5542 33 ICU ICU NNP cord-015021-pol2qm74 5542 34 admission admission NN cord-015021-pol2qm74 5542 35 , , , cord-015021-pol2qm74 5542 36 a a DT cord-015021-pol2qm74 5542 37 much much RB cord-015021-pol2qm74 5542 38 stronger strong JJR cord-015021-pol2qm74 5542 39 correlation correlation NN cord-015021-pol2qm74 5542 40 is be VBZ cord-015021-pol2qm74 5542 41 evident evident JJ cord-015021-pol2qm74 5542 42 between between IN cord-015021-pol2qm74 5542 43 the the DT cord-015021-pol2qm74 5542 44 severity severity NN cord-015021-pol2qm74 5542 45 of of IN cord-015021-pol2qm74 5542 46 MODS mods NN cord-015021-pol2qm74 5542 47 and and CC cord-015021-pol2qm74 5542 48 the the DT cord-015021-pol2qm74 5542 49 subsequent subsequent JJ cord-015021-pol2qm74 5542 50 development development NN cord-015021-pol2qm74 5542 51 of of IN cord-015021-pol2qm74 5542 52 nosocomial nosocomial JJ cord-015021-pol2qm74 5542 53 ICU ICU NNP cord-015021-pol2qm74 5542 54 - - HYPH cord-015021-pol2qm74 5542 55 acquired acquire VBN cord-015021-pol2qm74 5542 56 infection infection NN cord-015021-pol2qm74 5542 57 . . . cord-015021-pol2qm74 5543 1 Furthermore furthermore RB cord-015021-pol2qm74 5543 2 the the DT cord-015021-pol2qm74 5543 3 severity severity NN cord-015021-pol2qm74 5543 4 of of IN cord-015021-pol2qm74 5543 5 MODS MODS NNP cord-015021-pol2qm74 5543 6 correlates correlate VBZ cord-015021-pol2qm74 5543 7 strongly strongly RB cord-015021-pol2qm74 5543 8 with with IN cord-015021-pol2qm74 5543 9 the the DT cord-015021-pol2qm74 5543 10 severity severity NN cord-015021-pol2qm74 5543 11 of of IN cord-015021-pol2qm74 5543 12 the the DT cord-015021-pol2qm74 5543 13 clinical clinical JJ cord-015021-pol2qm74 5543 14 septic septic JJ cord-015021-pol2qm74 5543 15 response response NN cord-015021-pol2qm74 5543 16 , , , cord-015021-pol2qm74 5543 17 and and CC cord-015021-pol2qm74 5543 18 with with IN cord-015021-pol2qm74 5543 19 the the DT cord-015021-pol2qm74 5543 20 degree degree NN cord-015021-pol2qm74 5543 21 of of IN cord-015021-pol2qm74 5543 22 immunologic immunologic JJ cord-015021-pol2qm74 5543 23 compromise compromise NN cord-015021-pol2qm74 5543 24 evident evident JJ cord-015021-pol2qm74 5543 25 on on IN cord-015021-pol2qm74 5543 26 delayed delayed JJ cord-015021-pol2qm74 5543 27 type type NN cord-015021-pol2qm74 5543 28 hypersensitivity hypersensitivity NN cord-015021-pol2qm74 5543 29 skin skin NN cord-015021-pol2qm74 5543 30 testing testing NN cord-015021-pol2qm74 5543 31 . . . cord-015021-pol2qm74 5544 1 To to TO cord-015021-pol2qm74 5544 2 determine determine VB cord-015021-pol2qm74 5544 3 the the DT cord-015021-pol2qm74 5544 4 relative relative JJ cord-015021-pol2qm74 5544 5 importance importance NN cord-015021-pol2qm74 5544 6 of of IN cord-015021-pol2qm74 5544 7 the the DT cord-015021-pol2qm74 5544 8 initial initial JJ cord-015021-pol2qm74 5544 9 stimulus stimulus NN cord-015021-pol2qm74 5544 10 , , , cord-015021-pol2qm74 5544 11 and and CC cord-015021-pol2qm74 5544 12 the the DT cord-015021-pol2qm74 5544 13 host host NN cord-015021-pol2qm74 5544 14 response response NN cord-015021-pol2qm74 5544 15 to to IN cord-015021-pol2qm74 5544 16 that that DT cord-015021-pol2qm74 5544 17 stimulus stimulus NN cord-015021-pol2qm74 5544 18 , , , cord-015021-pol2qm74 5544 19 to to IN cord-015021-pol2qm74 5544 20 the the DT cord-015021-pol2qm74 5544 21 subsequent subsequent JJ cord-015021-pol2qm74 5544 22 emergence emergence NN cord-015021-pol2qm74 5544 23 of of IN cord-015021-pol2qm74 5544 24 MODS mods NN cord-015021-pol2qm74 5544 25 , , , cord-015021-pol2qm74 5544 26 we -PRON- PRP cord-015021-pol2qm74 5544 27 undertook undertake VBD cord-015021-pol2qm74 5544 28 a a DT cord-015021-pol2qm74 5544 29 matched match VBN cord-015021-pol2qm74 5544 30 cohort cohort NN cord-015021-pol2qm74 5544 31 study study NN cord-015021-pol2qm74 5544 32 of of IN cord-015021-pol2qm74 5544 33 109 109 CD cord-015021-pol2qm74 5544 34 critically critically RB cord-015021-pol2qm74 5544 35 ill ill JJ cord-015021-pol2qm74 5544 36 patients patient NNS cord-015021-pol2qm74 5544 37 admitted admit VBN cord-015021-pol2qm74 5544 38 to to IN cord-015021-pol2qm74 5544 39 the the DT cord-015021-pol2qm74 5544 40 ICU ICU NNP cord-015021-pol2qm74 5544 41 with with IN cord-015021-pol2qm74 5544 42 infection infection NN cord-015021-pol2qm74 5544 43 , , , cord-015021-pol2qm74 5544 44 matched match VBN cord-015021-pol2qm74 5544 45 by by IN cord-015021-pol2qm74 5544 46 age age NN cord-015021-pol2qm74 5544 47 , , , cord-015021-pol2qm74 5544 48 sex sex NN cord-015021-pol2qm74 5544 49 , , , cord-015021-pol2qm74 5544 50 and and CC cord-015021-pol2qm74 5544 51 APACHE APACHE NNP cord-015021-pol2qm74 5544 52 II II NNP cord-015021-pol2qm74 5544 53 score score NN cord-015021-pol2qm74 5544 54 to to IN cord-015021-pol2qm74 5544 55 109 109 CD cord-015021-pol2qm74 5544 56 uninfected uninfected JJ cord-015021-pol2qm74 5544 57 controls control NNS cord-015021-pol2qm74 5544 58 . . . cord-015021-pol2qm74 5545 1 Organ organ NN cord-015021-pol2qm74 5545 2 dysfunction dysfunction NN cord-015021-pol2qm74 5545 3 scores score NNS cord-015021-pol2qm74 5545 4 were be VBD cord-015021-pol2qm74 5545 5 higher high JJR cord-015021-pol2qm74 5545 6 in in IN cord-015021-pol2qm74 5545 7 patients patient NNS cord-015021-pol2qm74 5545 8 admitted admit VBN cord-015021-pol2qm74 5545 9 with with IN cord-015021-pol2qm74 5545 10 infection infection NN cord-015021-pol2qm74 5545 11 , , , cord-015021-pol2qm74 5545 12 but but CC cord-015021-pol2qm74 5545 13 were be VBD cord-015021-pol2qm74 5545 14 also also RB cord-015021-pol2qm74 5545 15 significantly significantly RB cord-015021-pol2qm74 5545 16 associated associate VBN cord-015021-pol2qm74 5545 17 with with IN cord-015021-pol2qm74 5545 18 the the DT cord-015021-pol2qm74 5545 19 expression expression NN cord-015021-pol2qm74 5545 20 of of IN cord-015021-pol2qm74 5545 21 a a DT cord-015021-pol2qm74 5545 22 septic septic JJ cord-015021-pol2qm74 5545 23 response response NN cord-015021-pol2qm74 5545 24 at at IN cord-015021-pol2qm74 5545 25 the the DT cord-015021-pol2qm74 5545 26 time time NN cord-015021-pol2qm74 5545 27 of of IN cord-015021-pol2qm74 5545 28 ICU ICU NNP cord-015021-pol2qm74 5545 29 admission admission NN cord-015021-pol2qm74 5545 30 , , , cord-015021-pol2qm74 5545 31 independent independent JJ cord-015021-pol2qm74 5545 32 of of IN cord-015021-pol2qm74 5545 33 the the DT cord-015021-pol2qm74 5545 34 presence presence NN cord-015021-pol2qm74 5545 35 of of IN cord-015021-pol2qm74 5545 36 infection infection NN cord-015021-pol2qm74 5545 37 . . . cord-015021-pol2qm74 5546 1 By by IN cord-015021-pol2qm74 5546 2 stepwise stepwise JJ cord-015021-pol2qm74 5546 3 regression regression NN cord-015021-pol2qm74 5546 4 analysis analysis NN cord-015021-pol2qm74 5546 5 , , , cord-015021-pol2qm74 5546 6 the the DT cord-015021-pol2qm74 5546 7 magnitude magnitude NN cord-015021-pol2qm74 5546 8 of of IN cord-015021-pol2qm74 5546 9 the the DT cord-015021-pol2qm74 5546 10 septic septic JJ cord-015021-pol2qm74 5546 11 response response NN cord-015021-pol2qm74 5546 12 was be VBD cord-015021-pol2qm74 5546 13 the the DT cord-015021-pol2qm74 5546 14 most most RBS cord-015021-pol2qm74 5546 15 powerful powerful JJ cord-015021-pol2qm74 5546 16 predictor predictor NN cord-015021-pol2qm74 5546 17 of of IN cord-015021-pol2qm74 5546 18 the the DT cord-015021-pol2qm74 5546 19 severity severity NN cord-015021-pol2qm74 5546 20 of of IN cord-015021-pol2qm74 5546 21 MODS mods NN cord-015021-pol2qm74 5546 22 in in IN cord-015021-pol2qm74 5546 23 both both CC cord-015021-pol2qm74 5546 24 infected infected JJ cord-015021-pol2qm74 5546 25 and and CC cord-015021-pol2qm74 5546 26 uninfected uninfected JJ cord-015021-pol2qm74 5546 27 patients patient NNS cord-015021-pol2qm74 5546 28 . . . cord-015021-pol2qm74 5547 1 These these DT cord-015021-pol2qm74 5547 2 data datum NNS cord-015021-pol2qm74 5547 3 suggest suggest VBP cord-015021-pol2qm74 5547 4 a a DT cord-015021-pol2qm74 5547 5 model model NN cord-015021-pol2qm74 5547 6 of of IN cord-015021-pol2qm74 5547 7 MODS mods NN cord-015021-pol2qm74 5547 8 in in IN cord-015021-pol2qm74 5547 9 which which WDT cord-015021-pol2qm74 5547 10 a a DT cord-015021-pol2qm74 5547 11 stimulus stimulus NN cord-015021-pol2qm74 5547 12 ( ( -LRB- cord-015021-pol2qm74 5547 13 eg eg IN cord-015021-pol2qm74 5547 14 infection infection NN cord-015021-pol2qm74 5547 15 ) ) -RRB- cord-015021-pol2qm74 5547 16 and and CC cord-015021-pol2qm74 5547 17 the the DT cord-015021-pol2qm74 5547 18 host host NN cord-015021-pol2qm74 5547 19 response response NN cord-015021-pol2qm74 5547 20 to to IN cord-015021-pol2qm74 5547 21 that that DT cord-015021-pol2qm74 5547 22 stimulus stimulus NN cord-015021-pol2qm74 5547 23 ( ( -LRB- cord-015021-pol2qm74 5547 24 eg eg IN cord-015021-pol2qm74 5547 25 the the DT cord-015021-pol2qm74 5547 26 septic septic JJ cord-015021-pol2qm74 5547 27 response response NN cord-015021-pol2qm74 5547 28 ) ) -RRB- cord-015021-pol2qm74 5547 29 result result NN cord-015021-pol2qm74 5547 30 in in IN cord-015021-pol2qm74 5547 31 a a DT cord-015021-pol2qm74 5547 32 state state NN cord-015021-pol2qm74 5547 33 of of IN cord-015021-pol2qm74 5547 34 altered alter VBN cord-015021-pol2qm74 5547 35 systemic systemic JJ cord-015021-pol2qm74 5547 36 homeostasis homeostasis NN cord-015021-pol2qm74 5547 37 ( ( -LRB- cord-015021-pol2qm74 5547 38 manifested manifest VBN cord-015021-pol2qm74 5547 39 in in IN cord-015021-pol2qm74 5547 40 this this DT cord-015021-pol2qm74 5547 41 example example NN cord-015021-pol2qm74 5547 42 by by IN cord-015021-pol2qm74 5547 43 immunologic immunologic JJ cord-015021-pol2qm74 5547 44 dysfunction dysfunction NN cord-015021-pol2qm74 5547 45 ) ) -RRB- cord-015021-pol2qm74 5547 46 . . . cord-015021-pol2qm74 5548 1 Moreover moreover RB cord-015021-pol2qm74 5548 2 they -PRON- PRP cord-015021-pol2qm74 5548 3 suggest suggest VBP cord-015021-pol2qm74 5548 4 that that IN cord-015021-pol2qm74 5548 5 the the DT cord-015021-pol2qm74 5548 6 principle principle JJ cord-015021-pol2qm74 5548 7 determinant determinant NN cord-015021-pol2qm74 5548 8 of of IN cord-015021-pol2qm74 5548 9 the the DT cord-015021-pol2qm74 5548 10 emergence emergence NN cord-015021-pol2qm74 5548 11 of of IN cord-015021-pol2qm74 5548 12 MODS MODS NNP cord-015021-pol2qm74 5548 13 is be VBZ cord-015021-pol2qm74 5548 14 the the DT cord-015021-pol2qm74 5548 15 response response NN cord-015021-pol2qm74 5548 16 of of IN cord-015021-pol2qm74 5548 17 the the DT cord-015021-pol2qm74 5548 18 host host NN cord-015021-pol2qm74 5548 19 , , , cord-015021-pol2qm74 5548 20 rather rather RB cord-015021-pol2qm74 5548 21 than than IN cord-015021-pol2qm74 5548 22 the the DT cord-015021-pol2qm74 5548 23 nature nature NN cord-015021-pol2qm74 5548 24 of of IN cord-015021-pol2qm74 5548 25 the the DT cord-015021-pol2qm74 5548 26 stimulus stimulus NN cord-015021-pol2qm74 5548 27 , , , cord-015021-pol2qm74 5548 28 and and CC cord-015021-pol2qm74 5548 29 are be VBP cord-015021-pol2qm74 5548 30 consistent consistent JJ cord-015021-pol2qm74 5548 31 with with IN cord-015021-pol2qm74 5548 32 the the DT cord-015021-pol2qm74 5548 33 hypothesis hypothesis NN cord-015021-pol2qm74 5548 34 that that IN cord-015021-pol2qm74 5548 35 a a DT cord-015021-pol2qm74 5548 36 stereotypie stereotypie JJ cord-015021-pol2qm74 5548 37 systemic systemic JJ cord-015021-pol2qm74 5548 38 response response NN cord-015021-pol2qm74 5548 39 to to IN cord-015021-pol2qm74 5548 40 an an DT cord-015021-pol2qm74 5548 41 heterogeneous heterogeneous JJ cord-015021-pol2qm74 5548 42 group group NN cord-015021-pol2qm74 5548 43 of of IN cord-015021-pol2qm74 5548 44 injurious injurious JJ cord-015021-pol2qm74 5548 45 stimuli stimulus NNS cord-015021-pol2qm74 5548 46 underlies underlie VBZ cord-015021-pol2qm74 5548 47 the the DT cord-015021-pol2qm74 5548 48 pathogenesis pathogenesis NN cord-015021-pol2qm74 5548 49 of of IN cord-015021-pol2qm74 5548 50 MODS mod NNS cord-015021-pol2qm74 5548 51 . . . cord-015021-pol2qm74 5549 1 Arthur Arthur NNP cord-015021-pol2qm74 5549 2 E. E. NNP cord-015021-pol2qm74 5549 3 Baue Baue NNP cord-015021-pol2qm74 5549 4 , , , cord-015021-pol2qm74 5549 5 M.D M.D NNP cord-015021-pol2qm74 5549 6 , , , cord-015021-pol2qm74 5550 1 Ever ever RB cord-015021-pol2qm74 5550 2 since since IN cord-015021-pol2qm74 5550 3 the the DT cord-015021-pol2qm74 5550 4 attorapt attorapt NNP cord-015021-pol2qm74 5550 5 10 10 CD cord-015021-pol2qm74 5550 6 build build NN cord-015021-pol2qm74 5550 7 the the DT cord-015021-pol2qm74 5550 8 Tower Tower NNP cord-015021-pol2qm74 5550 9 ef ef NNP cord-015021-pol2qm74 5550 10 Babel Babel NNP cord-015021-pol2qm74 5550 11 , , , cord-015021-pol2qm74 5550 12 as as IN cord-015021-pol2qm74 5550 13 desclibcd desclibcd NN cord-015021-pol2qm74 5550 14 in in IN cord-015021-pol2qm74 5550 15 the the DT cord-015021-pol2qm74 5550 16 Old Old NNP cord-015021-pol2qm74 5550 17 Testament Testament NNP cord-015021-pol2qm74 5550 18 of of IN cord-015021-pol2qm74 5550 19 the the DT cord-015021-pol2qm74 5550 20 Biblc Biblc NNP cord-015021-pol2qm74 5550 21 , , , cord-015021-pol2qm74 5550 22 it -PRON- PRP cord-015021-pol2qm74 5550 23 has have VBZ cord-015021-pol2qm74 5550 24 been be VBN cord-015021-pol2qm74 5550 25 difficult difficult JJ cord-015021-pol2qm74 5550 26 to to TO cord-015021-pol2qm74 5550 27 got got VB cord-015021-pol2qm74 5550 28 agreement agreement NN cord-015021-pol2qm74 5551 1 o;x o;x IN cord-015021-pol2qm74 5551 2 common common JJ cord-015021-pol2qm74 5551 3 definitions definition NNS cord-015021-pol2qm74 5551 4 or or CC cord-015021-pol2qm74 5551 5 language language NN cord-015021-pol2qm74 5552 1 , , , cord-015021-pol2qm74 5552 2 Although although IN cord-015021-pol2qm74 5552 3 MOF MOF NNP cord-015021-pol2qm74 5552 4 has have VBZ cord-015021-pol2qm74 5552 5 served serve VBN cord-015021-pol2qm74 5552 6 well well RB cord-015021-pol2qm74 5552 7 , , , cord-015021-pol2qm74 5552 8 there there EX cord-015021-pol2qm74 5552 9 will will MD cord-015021-pol2qm74 5552 10 always always RB cord-015021-pol2qm74 5552 11 he -PRON- PRP cord-015021-pol2qm74 5552 12 now now RB cord-015021-pol2qm74 5552 13 classifications classification NNS cord-015021-pol2qm74 5552 14 proposed propose VBN cord-015021-pol2qm74 5552 15 with with IN cord-015021-pol2qm74 5552 16 good good JJ cord-015021-pol2qm74 5552 17 reasons reason NNS cord-015021-pol2qm74 5552 18 for for IN cord-015021-pol2qm74 5552 19 them -PRON- PRP cord-015021-pol2qm74 5552 20 , , , cord-015021-pol2qm74 5552 21 Thus thus RB cord-015021-pol2qm74 5552 22 MODS MODS NNP cord-015021-pol2qm74 5552 23 and and CC cord-015021-pol2qm74 5552 24 SIRS sir NNS cord-015021-pol2qm74 5552 25 are be VBP cord-015021-pol2qm74 5552 26 not not RB cord-015021-pol2qm74 5552 27 the the DT cord-015021-pol2qm74 5552 28 final final JJ cord-015021-pol2qm74 5552 29 oxpressinns oxpressinns NN cord-015021-pol2qm74 5552 30 in in IN cord-015021-pol2qm74 5552 31 the the DT cord-015021-pol2qm74 5552 32 lexico lexico NNP cord-015021-pol2qm74 5552 33 ~ ~ NFP cord-015021-pol2qm74 5552 34 aphic aphic NNP cord-015021-pol2qm74 5552 35 sweepstakes sweepstakes NNP cord-015021-pol2qm74 5552 36 . . . cord-015021-pol2qm74 5553 1 Attcmpts attcmpts JJ cord-015021-pol2qm74 5553 2 to to TO cord-015021-pol2qm74 5553 3 develop develop VB cord-015021-pol2qm74 5553 4 standard standard JJ cord-015021-pol2qm74 5553 5 animal animal NN cord-015021-pol2qm74 5553 6 shock shock NN cord-015021-pol2qm74 5553 7 and and CC cord-015021-pol2qm74 5553 8 scpsis scpsis NN cord-015021-pol2qm74 5553 9 models model NNS cord-015021-pol2qm74 5553 10 ( ( -LRB- cord-015021-pol2qm74 5553 11 hemorrhage hemorrhage NN cord-015021-pol2qm74 5553 12 , , , cord-015021-pol2qm74 5553 13 endotoxin endotoxin NN cord-015021-pol2qm74 5553 14 , , , cord-015021-pol2qm74 5553 15 foes foe NNS cord-015021-pol2qm74 5553 16 [ [ -LRB- cord-015021-pol2qm74 5553 17 pellets pellet NNS cord-015021-pol2qm74 5553 18 , , , cord-015021-pol2qm74 5553 19 cecal cecal JJ cord-015021-pol2qm74 5553 20 ligation ligation NN cord-015021-pol2qm74 5553 21 and and CC cord-015021-pol2qm74 5553 22 puncture puncture NN cord-015021-pol2qm74 5553 23 , , , cord-015021-pol2qm74 5553 24 E. E. NNP cord-015021-pol2qm74 5553 25 colt colt NN cord-015021-pol2qm74 5553 26 hlf0sioI0 hlf0sioI0 NNP cord-015021-pol2qm74 5553 27 to to TO cord-015021-pol2qm74 5553 28 evaluate evaluate VB cord-015021-pol2qm74 5553 29 therapy therapy NN cord-015021-pol2qm74 5553 30 have have VBP cord-015021-pol2qm74 5553 31 net net NN cord-015021-pol2qm74 5553 32 been be VBN cord-015021-pol2qm74 5553 33 suoca.ssf~. suoca.ssf~. NNP cord-015021-pol2qm74 5553 34 Clinical clinical JJ cord-015021-pol2qm74 5553 35 syndromes syndrome NNS cord-015021-pol2qm74 5553 36 of of IN cord-015021-pol2qm74 5553 37 MOF MOF NNP cord-015021-pol2qm74 5553 38 , , , cord-015021-pol2qm74 5553 39 sepsis sepsis NN cord-015021-pol2qm74 5553 40 , , , cord-015021-pol2qm74 5553 41 sepsis sepsis NN cord-015021-pol2qm74 5553 42 syndrome syndrome NN cord-015021-pol2qm74 5553 43 and and CC cord-015021-pol2qm74 5553 44 athers ather NNS cord-015021-pol2qm74 5553 45 have have VBP cord-015021-pol2qm74 5553 46 not not RB cord-015021-pol2qm74 5553 47 been be VBN cord-015021-pol2qm74 5553 48 aeacpte.d aeacpte.d JJ cord-015021-pol2qm74 5553 49 by by RB cord-015021-pol2qm74 5553 50 all all DT cord-015021-pol2qm74 5553 51 . . . cord-015021-pol2qm74 5554 1 Our -PRON- PRP$ cord-015021-pol2qm74 5554 2 problem problem NN cord-015021-pol2qm74 5554 3 is be VBZ cord-015021-pol2qm74 5554 4 that that IN cord-015021-pol2qm74 5554 5 we -PRON- PRP cord-015021-pol2qm74 5554 6 arc arc VBP cord-015021-pol2qm74 5555 1 tryittg tryittg NNP cord-015021-pol2qm74 5555 2 tu tu NNP cord-015021-pol2qm74 5555 3 d¢ffino d¢ffino NNP cord-015021-pol2qm74 5555 4 a a DT cord-015021-pol2qm74 5555 5 non non JJ cord-015021-pol2qm74 5555 6 - - JJ cord-015021-pol2qm74 5555 7 emily emily NNP cord-015021-pol2qm74 5555 8 . . . cord-015021-pol2qm74 5556 1 MOF MOF NNP cord-015021-pol2qm74 5556 2 or or CC cord-015021-pol2qm74 5556 3 MODS MODS NNP cord-015021-pol2qm74 5556 4 or or CC cord-015021-pol2qm74 5556 5 SIRS SIRS NNP cord-015021-pol2qm74 5556 6 is be VBZ cord-015021-pol2qm74 5556 7 net net PDT cord-015021-pol2qm74 5556 8 a a DT cord-015021-pol2qm74 5556 9 disease disease NN cord-015021-pol2qm74 5556 10 or or CC cord-015021-pol2qm74 5556 11 oven oven NN cord-015021-pol2qm74 5556 12 a a DT cord-015021-pol2qm74 5556 13 syndrome syndrome NN cord-015021-pol2qm74 5556 14 . . . cord-015021-pol2qm74 5557 1 It -PRON- PRP cord-015021-pol2qm74 5557 2 is be VBZ cord-015021-pol2qm74 5557 3 a a DT cord-015021-pol2qm74 5557 4 series series NN cord-015021-pol2qm74 5557 5 of of IN cord-015021-pol2qm74 5557 6 complications complication NNS cord-015021-pol2qm74 5557 7 of of IN cord-015021-pol2qm74 5557 8 injury injury NN cord-015021-pol2qm74 5557 9 , , , cord-015021-pol2qm74 5557 10 disease disease NN cord-015021-pol2qm74 5557 11 and and CC cord-015021-pol2qm74 5557 12 intensiva intensiva NN cord-015021-pol2qm74 5557 13 care care NN cord-015021-pol2qm74 5557 14 which which WDT cord-015021-pol2qm74 5557 15 loads load VBZ cord-015021-pol2qm74 5557 16 to to IN cord-015021-pol2qm74 5557 17 death death NN cord-015021-pol2qm74 5557 18 for for IN cord-015021-pol2qm74 5557 19 many many JJ cord-015021-pol2qm74 5557 20 patients patient NNS cord-015021-pol2qm74 5557 21 in in IN cord-015021-pol2qm74 5557 22 intensive intensive JJ cord-015021-pol2qm74 5557 23 care care NN cord-015021-pol2qm74 5557 24 units unit NNS cord-015021-pol2qm74 5557 25 , , , cord-015021-pol2qm74 5557 26 It -PRON- PRP cord-015021-pol2qm74 5557 27 is be VBZ cord-015021-pol2qm74 5557 28 not not RB cord-015021-pol2qm74 5557 29 a a DT cord-015021-pol2qm74 5557 30 fixed fix VBN cord-015021-pol2qm74 5557 31 entity entity NN cord-015021-pol2qm74 5557 32 , , , cord-015021-pol2qm74 5557 33 but but CC cord-015021-pol2qm74 5557 34 an an DT cord-015021-pol2qm74 5557 35 ewilving ewilve VBG cord-015021-pol2qm74 5557 36 picture picture NN cord-015021-pol2qm74 5557 37 . . . cord-015021-pol2qm74 5558 1 We -PRON- PRP cord-015021-pol2qm74 5558 2 have have VBP cord-015021-pol2qm74 5558 3 lumped lump VBN cord-015021-pol2qm74 5558 4 ( ( -LRB- cord-015021-pol2qm74 5558 5 ugethet ugethet NNP cord-015021-pol2qm74 5558 6 for for IN cord-015021-pol2qm74 5558 7 therapy therapy NN cord-015021-pol2qm74 5558 8 and and CC cord-015021-pol2qm74 5558 9 definition definition NN cord-015021-pol2qm74 5558 10 a a DT cord-015021-pol2qm74 5558 11 number number NN cord-015021-pol2qm74 5558 12 of of IN cord-015021-pol2qm74 5558 13 diseases disease NNS cord-015021-pol2qm74 5558 14 and and CC cord-015021-pol2qm74 5558 15 problems problem NNS cord-015021-pol2qm74 5558 16 according accord VBG cord-015021-pol2qm74 5558 17 to to IN cord-015021-pol2qm74 5558 18 clinical clinical JJ cord-015021-pol2qm74 5558 19 manifestatieos manifestatieos NN cord-015021-pol2qm74 5558 20 rather rather RB cord-015021-pol2qm74 5558 21 than than IN cord-015021-pol2qm74 5558 22 the the DT cord-015021-pol2qm74 5558 23 eause eause NN cord-015021-pol2qm74 5558 24 of of IN cord-015021-pol2qm74 5558 25 Ihe Ihe NNP cord-015021-pol2qm74 5558 26 problem problem NN cord-015021-pol2qm74 5558 27 , , , cord-015021-pol2qm74 5558 28 The the DT cord-015021-pol2qm74 5558 29 search search NN cord-015021-pol2qm74 5558 30 for for IN cord-015021-pol2qm74 5558 31 unified unified JJ cord-015021-pol2qm74 5558 32 mechanisms mechanism NNS cord-015021-pol2qm74 5558 33 has have VBZ cord-015021-pol2qm74 5558 34 not not RB cord-015021-pol2qm74 5558 35 bean bean NN cord-015021-pol2qm74 5558 36 successful successful JJ cord-015021-pol2qm74 5558 37 . . . cord-015021-pol2qm74 5559 1 Will Will MD cord-015021-pol2qm74 5559 2 we -PRON- PRP cord-015021-pol2qm74 5559 3 benefit benefit VB cord-015021-pol2qm74 5559 4 Oleo Oleo NNP cord-015021-pol2qm74 5559 5 from from IN cord-015021-pol2qm74 5559 6 a a DT cord-015021-pol2qm74 5559 7 more more RBR cord-015021-pol2qm74 5559 8 precise precise JJ cord-015021-pol2qm74 5559 9 classification classification NN cord-015021-pol2qm74 5559 10 and and CC cord-015021-pol2qm74 5559 11 definition definition NN cord-015021-pol2qm74 5559 12 of of IN cord-015021-pol2qm74 5559 13 a a DT cord-015021-pol2qm74 5559 14 non non JJ cord-015021-pol2qm74 5559 15 - - JJ cord-015021-pol2qm74 5559 16 outjty outjty JJ cord-015021-pol2qm74 5559 17 , , , cord-015021-pol2qm74 5559 18 a a DT cord-015021-pol2qm74 5559 19 hodgu hodgu NN cord-015021-pol2qm74 5559 20 - - HYPH cord-015021-pol2qm74 5559 21 podge podge NN cord-015021-pol2qm74 5559 22 of of IN cord-015021-pol2qm74 5559 23 human human JJ cord-015021-pol2qm74 5559 24 disorders disorder NNS cord-015021-pol2qm74 5559 25 which which WDT cord-015021-pol2qm74 5559 26 have have VBP cord-015021-pol2qm74 5559 27 charsmeristic.s charsmeristic.s NN cord-015021-pol2qm74 5559 28 and and CC cord-015021-pol2qm74 5559 29 manifestations manifestation NNS cord-015021-pol2qm74 5559 30 of of IN cord-015021-pol2qm74 5559 31 tissue tissue NN cord-015021-pol2qm74 5559 32 injury injury NN cord-015021-pol2qm74 5559 33 , , , cord-015021-pol2qm74 5559 34 inflammation inflammation NN cord-015021-pol2qm74 5559 35 and and CC cord-015021-pol2qm74 5559 36 infactian infactian NN cord-015021-pol2qm74 5559 37 ? ? . cord-015021-pol2qm74 5560 1 Re.hi re.hi DT cord-015021-pol2qm74 5560 2 clinical clinical JJ cord-015021-pol2qm74 5560 3 trials trial NNS cord-015021-pol2qm74 5560 4 of of IN cord-015021-pol2qm74 5560 5 potential potential JJ cord-015021-pol2qm74 5560 6 " " `` cord-015021-pol2qm74 5560 7 magle magle NNP cord-015021-pol2qm74 5560 8 ballets ballet NNS cord-015021-pol2qm74 5560 9 " " '' cord-015021-pol2qm74 5560 10 suggest suggest VBP cord-015021-pol2qm74 5560 11 that that IN cord-015021-pol2qm74 5560 12 we -PRON- PRP cord-015021-pol2qm74 5560 13 should should MD cord-015021-pol2qm74 5560 14 go go VB cord-015021-pol2qm74 5560 15 in in IN cord-015021-pol2qm74 5560 16 a a DT cord-015021-pol2qm74 5560 17 different different JJ cord-015021-pol2qm74 5560 18 direction direction NN cord-015021-pol2qm74 5560 19 -- -- : cord-015021-pol2qm74 5560 20 instead instead RB cord-015021-pol2qm74 5560 21 of of IN cord-015021-pol2qm74 5560 22 lumpors lumpor NNS cord-015021-pol2qm74 5560 23 , , , cord-015021-pol2qm74 5560 24 we -PRON- PRP cord-015021-pol2qm74 5560 25 should should MD cord-015021-pol2qm74 5560 26 be be VB cord-015021-pol2qm74 5560 27 splitters splitter NNS cord-015021-pol2qm74 5560 28 , , , cord-015021-pol2qm74 5560 29 To to TO cord-015021-pol2qm74 5560 30 seek seek VB cord-015021-pol2qm74 5560 31 effective effective JJ cord-015021-pol2qm74 5560 32 therapy therapy NN cord-015021-pol2qm74 5560 33 , , , cord-015021-pol2qm74 5560 34 we -PRON- PRP cord-015021-pol2qm74 5560 35 must must MD cord-015021-pol2qm74 5560 36 fucus fucus VB cord-015021-pol2qm74 5560 37 on on IN cord-015021-pol2qm74 5560 38 specific specific JJ cord-015021-pol2qm74 5560 39 disorders disorder NNS cord-015021-pol2qm74 5560 40 such such JJ cord-015021-pol2qm74 5560 41 as as IN cord-015021-pol2qm74 5560 42 trauma trauma NN cord-015021-pol2qm74 5560 43 , , , cord-015021-pol2qm74 5560 44 specific specific JJ cord-015021-pol2qm74 5560 45 infections infection NNS cord-015021-pol2qm74 5560 46 , , , cord-015021-pol2qm74 5560 47 inflammatory inflammatory JJ cord-015021-pol2qm74 5560 48 disease disease NN cord-015021-pol2qm74 5560 49 and and CC cord-015021-pol2qm74 5560 50 chronic chronic JJ cord-015021-pol2qm74 5560 51 or or CC cord-015021-pol2qm74 5560 52 acute acute JJ cord-015021-pol2qm74 5560 53 organ organ NN cord-015021-pol2qm74 5560 54 damage damage NN cord-015021-pol2qm74 5561 1 ( ( -LRB- cord-015021-pol2qm74 5561 2 COPD COPD NNP cord-015021-pol2qm74 5561 3 -renal -renal JJ cord-015021-pol2qm74 5561 4 failure failure NN cord-015021-pol2qm74 5561 5 , , , cord-015021-pol2qm74 5561 6 etc etc FW cord-015021-pol2qm74 5561 7 . . . cord-015021-pol2qm74 5561 8 ) ) -RRB- cord-015021-pol2qm74 5562 1 , , , cord-015021-pol2qm74 5562 2 I -PRON- PRP cord-015021-pol2qm74 5562 3 will will MD cord-015021-pol2qm74 5562 4 say say VB cord-015021-pol2qm74 5562 5 more more JJR cord-015021-pol2qm74 5562 6 aboet aboet NNP cord-015021-pol2qm74 5563 1 this this DT cord-015021-pol2qm74 5563 2 later later RB cord-015021-pol2qm74 5563 3 ha ha UH cord-015021-pol2qm74 5563 4 the the DT cord-015021-pol2qm74 5563 5 me.ethag me.ethag NNP cord-015021-pol2qm74 5563 6 . . . cord-015021-pol2qm74 5564 1 Thcre Thcre NNP cord-015021-pol2qm74 5564 2 is be VBZ cord-015021-pol2qm74 5564 3 cue cue NN cord-015021-pol2qm74 5564 4 potentially potentially RB cord-015021-pol2qm74 5564 5 important important JJ cord-015021-pol2qm74 5564 6 pert pert NN cord-015021-pol2qm74 5564 7 of of IN cord-015021-pol2qm74 5564 8 the the DT cord-015021-pol2qm74 5564 9 MODS MODS NNP cord-015021-pol2qm74 5564 10 proposal proposal NN cord-015021-pol2qm74 5564 11 , , , cord-015021-pol2qm74 5564 12 and and CC cord-015021-pol2qm74 5564 13 that that DT cord-015021-pol2qm74 5564 14 would would MD cord-015021-pol2qm74 5564 15 be be VB cord-015021-pol2qm74 5564 16 do do VB cord-015021-pol2qm74 5564 17 ~ ~ CD cord-015021-pol2qm74 5564 18 mcntation mcntation NN cord-015021-pol2qm74 5564 19 of of IN cord-015021-pol2qm74 5564 20 organ organ NN cord-015021-pol2qm74 5564 21 dysfunction dysfunction NN cord-015021-pol2qm74 5564 22 before before IN cord-015021-pol2qm74 5564 23 fsiiure fsiiure JJ cord-015021-pol2qm74 5564 24 occurs occur VBZ cord-015021-pol2qm74 5564 25 and and CC cord-015021-pol2qm74 5564 26 before before IN cord-015021-pol2qm74 5564 27 tile tile NN cord-015021-pol2qm74 5564 28 need need NN cord-015021-pol2qm74 5564 29 for for IN cord-015021-pol2qm74 5564 30 external external JJ cord-015021-pol2qm74 5564 31 supporl supporl NN cord-015021-pol2qm74 5564 32 dovelope dovelope NNP cord-015021-pol2qm74 5564 33 . . . cord-015021-pol2qm74 5565 1 This this DT cord-015021-pol2qm74 5565 2 could could MD cord-015021-pol2qm74 5565 3 lead lead VB cord-015021-pol2qm74 5565 4 to to IN cord-015021-pol2qm74 5565 5 hatter hatter NN cord-015021-pol2qm74 5565 6 methods method NNS cord-015021-pol2qm74 5565 7 of of IN cord-015021-pol2qm74 5565 8 preventing prevent VBG cord-015021-pol2qm74 5565 9 organ organ NN cord-015021-pol2qm74 5565 10 failure failure NN cord-015021-pol2qm74 5565 11 . . . cord-015021-pol2qm74 5566 1 Preveution preveution NN cord-015021-pol2qm74 5566 2 is be VBZ cord-015021-pol2qm74 5566 3 ultimately ultimately RB cord-015021-pol2qm74 5566 4 the the DT cord-015021-pol2qm74 5566 5 only only JJ cord-015021-pol2qm74 5566 6 answer answer NN cord-015021-pol2qm74 5566 7 to to IN cord-015021-pol2qm74 5566 8 organ organ NN cord-015021-pol2qm74 5566 9 failure failure NN cord-015021-pol2qm74 5566 10 , , , cord-015021-pol2qm74 5566 11 m m NNP cord-015021-pol2qm74 5566 12 MOF MOF NNP cord-015021-pol2qm74 5566 13 , , , cord-015021-pol2qm74 5566 14 MODS MODS NNP cord-015021-pol2qm74 5566 15 and and CC cord-015021-pol2qm74 5566 16 SIRS sir NNS cord-015021-pol2qm74 5566 17 . . . cord-015021-pol2qm74 5567 1 Have have VBP cord-015021-pol2qm74 5567 2 wo wo MD cord-015021-pol2qm74 5567 3 reached reach VBN cord-015021-pol2qm74 5567 4 a a DT cord-015021-pol2qm74 5567 5 consensus?--Only consensus?--only NN cord-015021-pol2qm74 5567 6 that that WDT cord-015021-pol2qm74 5567 7 we -PRON- PRP cord-015021-pol2qm74 5567 8 arc arc VBP cord-015021-pol2qm74 5567 9 dealing deal VBG cord-015021-pol2qm74 5567 10 wilh wilh NNP cord-015021-pol2qm74 5567 11 a a DT cord-015021-pol2qm74 5567 12 diffl diffl NNP cord-015021-pol2qm74 5568 1 ~x ~x NNP cord-015021-pol2qm74 5568 2 : : : cord-015021-pol2qm74 5568 3 lt lt NNP cord-015021-pol2qm74 5568 4 probtolR probtolR NNP cord-015021-pol2qm74 5568 5 looking look VBG cord-015021-pol2qm74 5568 6 for for IN cord-015021-pol2qm74 5568 7 solutlons solutlon NNS cord-015021-pol2qm74 5568 8 . . . cord-015021-pol2qm74 5569 1 Acute acute JJ cord-015021-pol2qm74 5569 2 lung lung NN cord-015021-pol2qm74 5569 3 injury injury NN cord-015021-pol2qm74 5569 4 ( ( -LRB- cord-015021-pol2qm74 5569 5 ALI ALI NNP cord-015021-pol2qm74 5569 6 ) ) -RRB- cord-015021-pol2qm74 5569 7 and and CC cord-015021-pol2qm74 5569 8 its -PRON- PRP$ cord-015021-pol2qm74 5569 9 most most RBS cord-015021-pol2qm74 5569 10 severe severe JJ cord-015021-pol2qm74 5569 11 form form NN cord-015021-pol2qm74 5569 12 , , , cord-015021-pol2qm74 5569 13 acute acute JJ cord-015021-pol2qm74 5569 14 respiratory respiratory JJ cord-015021-pol2qm74 5569 15 distress distress NN cord-015021-pol2qm74 5569 16 syndrome syndrome NN cord-015021-pol2qm74 5569 17 ( ( -LRB- cord-015021-pol2qm74 5569 18 ARDS ARDS NNP cord-015021-pol2qm74 5569 19 ) ) -RRB- cord-015021-pol2qm74 5569 20 characterized characterize VBN cord-015021-pol2qm74 5569 21 by by IN cord-015021-pol2qm74 5569 22 severe severe JJ cord-015021-pol2qm74 5569 23 hypoxemia hypoxemia NN cord-015021-pol2qm74 5569 24 , , , cord-015021-pol2qm74 5569 25 diffuse diffuse VB cord-015021-pol2qm74 5569 26 infiltration infiltration NN cord-015021-pol2qm74 5569 27 of of IN cord-015021-pol2qm74 5569 28 both both DT cord-015021-pol2qm74 5569 29 lungs lung NNS cord-015021-pol2qm74 5569 30 , , , cord-015021-pol2qm74 5569 31 a a DT cord-015021-pol2qm74 5569 32 reduction reduction NN cord-015021-pol2qm74 5569 33 of of IN cord-015021-pol2qm74 5569 34 compliance compliance NN cord-015021-pol2qm74 5569 35 and and CC cord-015021-pol2qm74 5569 36 a a DT cord-015021-pol2qm74 5569 37 wedgepresure wedgepresure NN cord-015021-pol2qm74 5570 1 lower low JJR cord-015021-pol2qm74 5570 2 than than IN cord-015021-pol2qm74 5570 3 18 18 CD cord-015021-pol2qm74 5570 4 mm mm NNP cord-015021-pol2qm74 5570 5 Hare Hare NNP cord-015021-pol2qm74 5570 6 related relate VBD cord-015021-pol2qm74 5570 7 to to IN cord-015021-pol2qm74 5570 8 direct direct JJ cord-015021-pol2qm74 5570 9 or or CC cord-015021-pol2qm74 5570 10 indirect indirect JJ cord-015021-pol2qm74 5570 11 injury injury NN cord-015021-pol2qm74 5570 12 . . . cord-015021-pol2qm74 5571 1 When when WRB cord-015021-pol2qm74 5571 2 ALIresults ALIresults NNP cord-015021-pol2qm74 5571 3 from from IN cord-015021-pol2qm74 5571 4 direct direct JJ cord-015021-pol2qm74 5571 5 injury injury NN cord-015021-pol2qm74 5571 6 ( ( -LRB- cord-015021-pol2qm74 5571 7 toxic toxic JJ cord-015021-pol2qm74 5571 8 agents agent NNS cord-015021-pol2qm74 5571 9 , , , cord-015021-pol2qm74 5571 10 lung lung NN cord-015021-pol2qm74 5571 11 contusion contusion NN cord-015021-pol2qm74 5571 12 , , , cord-015021-pol2qm74 5571 13 pneumonia pneumonia NN cord-015021-pol2qm74 5571 14 ) ) -RRB- cord-015021-pol2qm74 5571 15 , , , cord-015021-pol2qm74 5571 16 the the DT cord-015021-pol2qm74 5571 17 lesions lesion NNS cord-015021-pol2qm74 5571 18 of of IN cord-015021-pol2qm74 5571 19 epithelial epithelial JJ cord-015021-pol2qm74 5571 20 barrier barrier NN cord-015021-pol2qm74 5571 21 and and CC cord-015021-pol2qm74 5571 22 the the DT cord-015021-pol2qm74 5571 23 activation activation NN cord-015021-pol2qm74 5571 24 of of IN cord-015021-pol2qm74 5571 25 lung lung NN cord-015021-pol2qm74 5571 26 macrophages macrophage NNS cord-015021-pol2qm74 5571 27 are be VBP cord-015021-pol2qm74 5571 28 the the DT cord-015021-pol2qm74 5571 29 first first JJ cord-015021-pol2qm74 5571 30 events event NNS cord-015021-pol2qm74 5571 31 leading lead VBG cord-015021-pol2qm74 5571 32 to to IN cord-015021-pol2qm74 5571 33 the the DT cord-015021-pol2qm74 5571 34 release release NN cord-015021-pol2qm74 5571 35 of of IN cord-015021-pol2qm74 5571 36 inflammatory inflammatory JJ cord-015021-pol2qm74 5571 37 mediators mediator NNS cord-015021-pol2qm74 5571 38 wh wh NN cord-015021-pol2qm74 5571 39 : : : cord-015021-pol2qm74 5571 40 ch ch NNP cord-015021-pol2qm74 5571 41 are be VBP cord-015021-pol2qm74 5571 42 responsible responsible JJ cord-015021-pol2qm74 5571 43 for for IN cord-015021-pol2qm74 5571 44 alteration alteration NN cord-015021-pol2qm74 5571 45 of of IN cord-015021-pol2qm74 5571 46 the the DT cord-015021-pol2qm74 5571 47 membranar membranar NNP cord-015021-pol2qm74 5571 48 permeability permeability NN cord-015021-pol2qm74 5571 49 and and CC cord-015021-pol2qm74 5571 50 for for IN cord-015021-pol2qm74 5571 51 invasion invasion NN cord-015021-pol2qm74 5571 52 of of IN cord-015021-pol2qm74 5571 53 the the DT cord-015021-pol2qm74 5571 54 alveoli alveolus NNS cord-015021-pol2qm74 5571 55 by by IN cord-015021-pol2qm74 5571 56 fluids fluid NNS cord-015021-pol2qm74 5571 57 , , , cord-015021-pol2qm74 5571 58 proteins protein NNS cord-015021-pol2qm74 5571 59 and and CC cord-015021-pol2qm74 5571 60 cells cell NNS cord-015021-pol2qm74 5571 61 . . . cord-015021-pol2qm74 5572 1 An an DT cord-015021-pol2qm74 5572 2 inflammatory inflammatory JJ cord-015021-pol2qm74 5572 3 reaction reaction NN cord-015021-pol2qm74 5572 4 develops develop VBZ cord-015021-pol2qm74 5572 5 , , , cord-015021-pol2qm74 5572 6 with with IN cord-015021-pol2qm74 5572 7 injury injury NN cord-015021-pol2qm74 5572 8 to to IN cord-015021-pol2qm74 5572 9 endothelial endothelial JJ cord-015021-pol2qm74 5572 10 cells cell NNS cord-015021-pol2qm74 5572 11 , , , cord-015021-pol2qm74 5572 12 adhesion adhesion NN cord-015021-pol2qm74 5572 13 of of IN cord-015021-pol2qm74 5572 14 polymorpbonuclear polymorpbonuclear NNP cord-015021-pol2qm74 5572 15 leucocytes leucocytes NNP cord-015021-pol2qm74 5572 16 ( ( -LRB- cord-015021-pol2qm74 5572 17 PMN PMN NNP cord-015021-pol2qm74 5572 18 ) ) -RRB- cord-015021-pol2qm74 5572 19 and and CC cord-015021-pol2qm74 5572 20 the the DT cord-015021-pol2qm74 5572 21 release release NN cord-015021-pol2qm74 5572 22 in in IN cord-015021-pol2qm74 5572 23 blood blood NN cord-015021-pol2qm74 5572 24 stream stream NN cord-015021-pol2qm74 5572 25 of of IN cord-015021-pol2qm74 5572 26 intlammatory intlammatory JJ cord-015021-pol2qm74 5572 27 mediators mediator NNS cord-015021-pol2qm74 5572 28 dispersing disperse VBG cord-015021-pol2qm74 5572 29 the the DT cord-015021-pol2qm74 5572 30 inflammatory inflammatory JJ cord-015021-pol2qm74 5572 31 reaction reaction NN cord-015021-pol2qm74 5572 32 to to IN cord-015021-pol2qm74 5572 33 other other JJ cord-015021-pol2qm74 5572 34 organs organ NNS cord-015021-pol2qm74 5572 35 and and CC cord-015021-pol2qm74 5572 36 tissues tissue NNS cord-015021-pol2qm74 5572 37 . . . cord-015021-pol2qm74 5573 1 The the DT cord-015021-pol2qm74 5573 2 failure failure NN cord-015021-pol2qm74 5573 3 of of IN cord-015021-pol2qm74 5573 4 lung lung NN cord-015021-pol2qm74 5573 5 function function NN cord-015021-pol2qm74 5573 6 also also RB cord-015021-pol2qm74 5573 7 results result VBZ cord-015021-pol2qm74 5573 8 into into IN cord-015021-pol2qm74 5573 9 hypoxia hypoxia NN cord-015021-pol2qm74 5573 10 in in IN cord-015021-pol2qm74 5573 11 other other JJ cord-015021-pol2qm74 5573 12 organs organ NNS cord-015021-pol2qm74 5573 13 , , , cord-015021-pol2qm74 5573 14 leading lead VBG cord-015021-pol2qm74 5573 15 to to IN cord-015021-pol2qm74 5573 16 tissular tissular JJ cord-015021-pol2qm74 5573 17 ischemia ischemia NN cord-015021-pol2qm74 5573 18 , , , cord-015021-pol2qm74 5573 19 triggering trigger VBG cord-015021-pol2qm74 5573 20 an an DT cord-015021-pol2qm74 5573 21 inflammatory inflammatory JJ cord-015021-pol2qm74 5573 22 reaction reaction NN cord-015021-pol2qm74 5573 23 leading lead VBG cord-015021-pol2qm74 5573 24 to to IN cord-015021-pol2qm74 5573 25 organ organ NN cord-015021-pol2qm74 5573 26 dysfunction dysfunction NN cord-015021-pol2qm74 5573 27 . . . cord-015021-pol2qm74 5574 1 Frequent frequent JJ cord-015021-pol2qm74 5574 2 complications complication NNS cord-015021-pol2qm74 5574 3 of of IN cord-015021-pol2qm74 5574 4 direct direct JJ cord-015021-pol2qm74 5574 5 lung lung NN cord-015021-pol2qm74 5574 6 injury injury NN cord-015021-pol2qm74 5574 7 are be VBP cord-015021-pol2qm74 5574 8 septic septic JJ cord-015021-pol2qm74 5574 9 pneumonia pneumonia NN cord-015021-pol2qm74 5574 10 with with IN cord-015021-pol2qm74 5574 11 endotoxin endotoxin NN cord-015021-pol2qm74 5574 12 release release NN cord-015021-pol2qm74 5574 13 , , , cord-015021-pol2qm74 5574 14 phagocytes phagocyte NNS cord-015021-pol2qm74 5574 15 activation activation NN cord-015021-pol2qm74 5574 16 and and CC cord-015021-pol2qm74 5574 17 cytokine cytokine NN cord-015021-pol2qm74 5574 18 production production NN cord-015021-pol2qm74 5574 19 disseminating disseminate VBG cord-015021-pol2qm74 5574 20 inflammation inflammation NN cord-015021-pol2qm74 5574 21 . . . cord-015021-pol2qm74 5575 1 By by IN cord-015021-pol2qm74 5575 2 this this DT cord-015021-pol2qm74 5575 3 way way NN cord-015021-pol2qm74 5575 4 , , , cord-015021-pol2qm74 5575 5 direct direct JJ cord-015021-pol2qm74 5575 6 lung lung NN cord-015021-pol2qm74 5575 7 injury injury NN cord-015021-pol2qm74 5575 8 can can MD cord-015021-pol2qm74 5575 9 be be VB cord-015021-pol2qm74 5575 10 at at IN cord-015021-pol2qm74 5575 11 the the DT cord-015021-pol2qm74 5575 12 origin origin NN cord-015021-pol2qm74 5575 13 of of IN cord-015021-pol2qm74 5575 14 the the DT cord-015021-pol2qm74 5575 15 multiple multiple JJ cord-015021-pol2qm74 5575 16 organ organ NN cord-015021-pol2qm74 5575 17 dysfunction dysfunction NN cord-015021-pol2qm74 5575 18 syndrome syndrome NN cord-015021-pol2qm74 5575 19 ( ( -LRB- cord-015021-pol2qm74 5575 20 MODS MODS NNP cord-015021-pol2qm74 5575 21 ) ) -RRB- cord-015021-pol2qm74 5575 22 , , , cord-015021-pol2qm74 5575 23 the the DT cord-015021-pol2qm74 5575 24 frequence frequence NN cord-015021-pol2qm74 5575 25 of of IN cord-015021-pol2qm74 5575 26 which which WDT cord-015021-pol2qm74 5575 27 having have VBG cord-015021-pol2qm74 5575 28 been be VBN cord-015021-pol2qm74 5575 29 estimated estimate VBN cord-015021-pol2qm74 5575 30 to to IN cord-015021-pol2qm74 5575 31 40 40 CD cord-015021-pol2qm74 5575 32 % % NN cord-015021-pol2qm74 5575 33 and and CC cord-015021-pol2qm74 5575 34 is be VBZ cord-015021-pol2qm74 5575 35 increased increase VBN cord-015021-pol2qm74 5575 36 when when WRB cord-015021-pol2qm74 5575 37 ALl all DT cord-015021-pol2qm74 5575 38 has have VBZ cord-015021-pol2qm74 5575 39 occured occur VBN cord-015021-pol2qm74 5575 40 in in IN cord-015021-pol2qm74 5575 41 patients patient NNS cord-015021-pol2qm74 5575 42 alreadypresenting alreadypresente VBG cord-015021-pol2qm74 5575 43 an an DT cord-015021-pol2qm74 5575 44 organ organ NN cord-015021-pol2qm74 5575 45 dysfunction dysfunction NN cord-015021-pol2qm74 5575 46 ( ( -LRB- cord-015021-pol2qm74 5575 47 immunodepresslon immunodepresslon NNP cord-015021-pol2qm74 5575 48 , , , cord-015021-pol2qm74 5575 49 cancer cancer NN cord-015021-pol2qm74 5575 50 ... ... NFP cord-015021-pol2qm74 5575 51 ) ) -RRB- cord-015021-pol2qm74 5575 52 . . . cord-015021-pol2qm74 5576 1 When when WRB cord-015021-pol2qm74 5576 2 ALI ALI NNP cord-015021-pol2qm74 5576 3 results result VBZ cord-015021-pol2qm74 5576 4 from from IN cord-015021-pol2qm74 5576 5 redirect redirect NN cord-015021-pol2qm74 5576 6 or or CC cord-015021-pol2qm74 5576 7 extrathoraclc extrathoraclc JJ cord-015021-pol2qm74 5576 8 injury injury NN cord-015021-pol2qm74 5576 9 ( ( -LRB- cord-015021-pol2qm74 5576 10 trauma trauma NN cord-015021-pol2qm74 5576 11 , , , cord-015021-pol2qm74 5576 12 infections infection NNS cord-015021-pol2qm74 5576 13 , , , cord-015021-pol2qm74 5576 14 hypovolemic hypovolemic JJ cord-015021-pol2qm74 5576 15 shock shock NN cord-015021-pol2qm74 5576 16 , , , cord-015021-pol2qm74 5576 17 acute acute JJ cord-015021-pol2qm74 5576 18 pancreatitis pancreatitis NN cord-015021-pol2qm74 5576 19 ... ... NFP cord-015021-pol2qm74 5576 20 ) ) -RRB- cord-015021-pol2qm74 5576 21 , , , cord-015021-pol2qm74 5576 22 inflammatory inflammatory JJ cord-015021-pol2qm74 5576 23 mediators mediator NNS cord-015021-pol2qm74 5576 24 and and CC cord-015021-pol2qm74 5576 25 micro micro NNS cord-015021-pol2qm74 5576 26 - - HYPH cord-015021-pol2qm74 5576 27 aggregates aggregate NNS cord-015021-pol2qm74 5576 28 released release VBN cord-015021-pol2qm74 5576 29 in in IN cord-015021-pol2qm74 5576 30 particular particular JJ cord-015021-pol2qm74 5576 31 organs organ NNS cord-015021-pol2qm74 5576 32 or or CC cord-015021-pol2qm74 5576 33 tissues tissue NNS cord-015021-pol2qm74 5576 34 reach reach VB cord-015021-pol2qm74 5576 35 the the DT cord-015021-pol2qm74 5576 36 lung lung NN cord-015021-pol2qm74 5576 37 via via IN cord-015021-pol2qm74 5576 38 the the DT cord-015021-pol2qm74 5576 39 blood blood NN cord-015021-pol2qm74 5576 40 and and CC cord-015021-pol2qm74 5576 41 lymph lymph NN cord-015021-pol2qm74 5576 42 streams stream NNS cord-015021-pol2qm74 5576 43 , , , cord-015021-pol2qm74 5576 44 are be VBP cord-015021-pol2qm74 5576 45 filtered filter VBN cord-015021-pol2qm74 5576 46 in in IN cord-015021-pol2qm74 5576 47 the the DT cord-015021-pol2qm74 5576 48 organ organ NN cord-015021-pol2qm74 5576 49 or or CC cord-015021-pol2qm74 5576 50 trapped trap VBN cord-015021-pol2qm74 5576 51 in in IN cord-015021-pol2qm74 5576 52 the the DT cord-015021-pol2qm74 5576 53 lung lung NN cord-015021-pol2qm74 5576 54 capillaries capillary NNS cord-015021-pol2qm74 5576 55 , , , cord-015021-pol2qm74 5576 56 and and CC cord-015021-pol2qm74 5576 57 are be VBP cord-015021-pol2qm74 5576 58 responsible responsible JJ cord-015021-pol2qm74 5576 59 for for IN cord-015021-pol2qm74 5576 60 a a DT cord-015021-pol2qm74 5576 61 local local JJ cord-015021-pol2qm74 5576 62 inflammatory inflammatory JJ cord-015021-pol2qm74 5576 63 reactaon reactaon NNS cord-015021-pol2qm74 5576 64 ( ( -LRB- cord-015021-pol2qm74 5576 65 endothelial endothelial JJ cord-015021-pol2qm74 5576 66 cell cell NN cord-015021-pol2qm74 5576 67 activation activation NN cord-015021-pol2qm74 5576 68 , , , cord-015021-pol2qm74 5576 69 PMN pmn NN cord-015021-pol2qm74 5576 70 trapping trapping NN cord-015021-pol2qm74 5576 71 and and CC cord-015021-pol2qm74 5576 72 adhesion adhesion NN cord-015021-pol2qm74 5576 73 , , , cord-015021-pol2qm74 5576 74 platelet platelet NN cord-015021-pol2qm74 5576 75 aggregation aggregation NN cord-015021-pol2qm74 5576 76 , , , cord-015021-pol2qm74 5576 77 release release NN cord-015021-pol2qm74 5576 78 of of IN cord-015021-pol2qm74 5576 79 mediators mediator NNS cord-015021-pol2qm74 5576 80 ) ) -RRB- cord-015021-pol2qm74 5576 81 . . . cord-015021-pol2qm74 5577 1 Sepsis sepsis NN cord-015021-pol2qm74 5577 2 acts act NNS cord-015021-pol2qm74 5577 3 by by IN cord-015021-pol2qm74 5577 4 the the DT cord-015021-pol2qm74 5577 5 way way NN cord-015021-pol2qm74 5577 6 of of IN cord-015021-pol2qm74 5577 7 endotoxiu endotoxiu NN cord-015021-pol2qm74 5577 8 and and CC cord-015021-pol2qm74 5577 9 sequential sequential JJ cord-015021-pol2qm74 5577 10 eytokines eytokine NNS cord-015021-pol2qm74 5577 11 release release NN cord-015021-pol2qm74 5577 12 ( ( -LRB- cord-015021-pol2qm74 5577 13 TNF TNF NNP cord-015021-pol2qm74 5577 14 , , , cord-015021-pol2qm74 5577 15 ILl ILl NNP cord-015021-pol2qm74 5577 16 , , , cord-015021-pol2qm74 5577 17 ... ... NFP cord-015021-pol2qm74 5577 18 ) ) -RRB- cord-015021-pol2qm74 5577 19 while while IN cord-015021-pol2qm74 5577 20 trauma trauma NN cord-015021-pol2qm74 5577 21 with with IN cord-015021-pol2qm74 5577 22 important important JJ cord-015021-pol2qm74 5577 23 blood blood NN cord-015021-pol2qm74 5577 24 loss loss NN cord-015021-pol2qm74 5577 25 acts act NNS cord-015021-pol2qm74 5577 26 especially especially RB cord-015021-pol2qm74 5577 27 by by IN cord-015021-pol2qm74 5577 28 the the DT cord-015021-pol2qm74 5577 29 way way NN cord-015021-pol2qm74 5577 30 of of IN cord-015021-pol2qm74 5577 31 hypoperfusionreperfusion hypoperfusionreperfusion NN cord-015021-pol2qm74 5577 32 phenomena phenomenon NNS cord-015021-pol2qm74 5577 33 leading lead VBG cord-015021-pol2qm74 5577 34 to to IN cord-015021-pol2qm74 5577 35 a a DT cord-015021-pol2qm74 5577 36 disseminatedinflammatory disseminatedinflammatory JJ cord-015021-pol2qm74 5577 37 reaction reaction NN cord-015021-pol2qm74 5577 38 and and CC cord-015021-pol2qm74 5577 39 to to IN cord-015021-pol2qm74 5577 40 a a DT cord-015021-pol2qm74 5577 41 possible possible JJ cord-015021-pol2qm74 5577 42 bacterial bacterial JJ cord-015021-pol2qm74 5577 43 transloeation transloeation NN cord-015021-pol2qm74 5577 44 when when WRB cord-015021-pol2qm74 5577 45 intestinal intestinal JJ cord-015021-pol2qm74 5577 46 hypopeffnsion hypopeffnsion NN cord-015021-pol2qm74 5577 47 is be VBZ cord-015021-pol2qm74 5577 48 present present JJ cord-015021-pol2qm74 5577 49 . . . cord-015021-pol2qm74 5578 1 In in IN cord-015021-pol2qm74 5578 2 these these DT cord-015021-pol2qm74 5578 3 conditions condition NNS cord-015021-pol2qm74 5578 4 of of IN cord-015021-pol2qm74 5578 5 indirect indirect JJ cord-015021-pol2qm74 5578 6 injury injury NN cord-015021-pol2qm74 5578 7 , , , cord-015021-pol2qm74 5578 8 ALl all DT cord-015021-pol2qm74 5578 9 ( ( -LRB- cord-015021-pol2qm74 5578 10 or or CC cord-015021-pol2qm74 5578 11 ARDS ARDS NNP cord-015021-pol2qm74 5578 12 ) ) -RRB- cord-015021-pol2qm74 5578 13 is be VBZ cord-015021-pol2qm74 5578 14 a a DT cord-015021-pol2qm74 5578 15 Iocal Iocal NNP cord-015021-pol2qm74 5578 16 early early RB cord-015021-pol2qm74 5578 17 ( ( -LRB- cord-015021-pol2qm74 5578 18 often often RB cord-015021-pol2qm74 5578 19 the the DT cord-015021-pol2qm74 5578 20 first first JJ cord-015021-pol2qm74 5578 21 ) ) -RRB- cord-015021-pol2qm74 5578 22 manifestation manifestation NN cord-015021-pol2qm74 5578 23 of of IN cord-015021-pol2qm74 5578 24 a a DT cord-015021-pol2qm74 5578 25 general general JJ cord-015021-pol2qm74 5578 26 phenomenon phenomenon NN cord-015021-pol2qm74 5578 27 of of IN cord-015021-pol2qm74 5578 28 altered alter VBN cord-015021-pol2qm74 5578 29 membrane membrane NN cord-015021-pol2qm74 5578 30 permeability permeability NN cord-015021-pol2qm74 5578 31 and and CC cord-015021-pol2qm74 5578 32 inflammatory inflammatory JJ cord-015021-pol2qm74 5578 33 reaction reaction NN cord-015021-pol2qm74 5578 34 , , , cord-015021-pol2qm74 5578 35 easily easily RB cord-015021-pol2qm74 5578 36 and and CC cord-015021-pol2qm74 5578 37 rapidly rapidly RB cord-015021-pol2qm74 5578 38 recognized recognize VBN cord-015021-pol2qm74 5578 39 by by IN cord-015021-pol2qm74 5578 40 its -PRON- PRP$ cord-015021-pol2qm74 5578 41 clin clin NNP cord-015021-pol2qm74 5578 42 ~ ~ NNP cord-015021-pol2qm74 5578 43 cai cai NNP cord-015021-pol2qm74 5578 44 signs sign NNS cord-015021-pol2qm74 5578 45 . . . cord-015021-pol2qm74 5579 1 The the DT cord-015021-pol2qm74 5579 2 iung iung NNP cord-015021-pol2qm74 5579 3 is be VBZ cord-015021-pol2qm74 5579 4 one one CD cord-015021-pol2qm74 5579 5 of of IN cord-015021-pol2qm74 5579 6 the the DT cord-015021-pol2qm74 5579 7 numerous numerous JJ cord-015021-pol2qm74 5579 8 organs organ NNS cord-015021-pol2qm74 5579 9 participating participate VBG cord-015021-pol2qm74 5579 10 to to IN cord-015021-pol2qm74 5579 11 the the DT cord-015021-pol2qm74 5579 12 MODS mods NN cord-015021-pol2qm74 5579 13 , , , cord-015021-pol2qm74 5579 14 In in IN cord-015021-pol2qm74 5579 15 these these DT cord-015021-pol2qm74 5579 16 conditions condition NNS cord-015021-pol2qm74 5579 17 , , , cord-015021-pol2qm74 5579 18 the the DT cord-015021-pol2qm74 5579 19 mortality mortality NN cord-015021-pol2qm74 5579 20 rate rate NN cord-015021-pol2qm74 5579 21 is be VBZ cord-015021-pol2qm74 5579 22 high high JJ cord-015021-pol2qm74 5579 23 , , , cord-015021-pol2qm74 5579 24 reaching reach VBG cord-015021-pol2qm74 5579 25 more more JJR cord-015021-pol2qm74 5579 26 than than IN cord-015021-pol2qm74 5579 27 80 80 CD cord-015021-pol2qm74 5579 28 % % NN cord-015021-pol2qm74 5579 29 when when WRB cord-015021-pol2qm74 5579 30 sepsis sepsis NN cord-015021-pol2qm74 5579 31 is be VBZ cord-015021-pol2qm74 5579 32 present present JJ cord-015021-pol2qm74 5579 33 or or CC cord-015021-pol2qm74 5579 34 when when WRB cord-015021-pol2qm74 5579 35 at at RB cord-015021-pol2qm74 5579 36 least least JJS cord-015021-pol2qm74 5579 37 3 3 CD cord-015021-pol2qm74 5579 38 organs organ NNS cord-015021-pol2qm74 5579 39 are be VBP cord-015021-pol2qm74 5579 40 implicated implicate VBN cord-015021-pol2qm74 5579 41 in in IN cord-015021-pol2qm74 5579 42 MODS mods NN cord-015021-pol2qm74 5579 43 . . . cord-015021-pol2qm74 5580 1 By by IN cord-015021-pol2qm74 5580 2 direct direct JJ cord-015021-pol2qm74 5580 3 or or CC cord-015021-pol2qm74 5580 4 redirect redirect VB cord-015021-pol2qm74 5580 5 injury injury NN cord-015021-pol2qm74 5580 6 , , , cord-015021-pol2qm74 5580 7 lung lung NN cord-015021-pol2qm74 5580 8 is be VBZ cord-015021-pol2qm74 5580 9 so so RB cord-015021-pol2qm74 5580 10 a a DT cord-015021-pol2qm74 5580 11 target target NN cord-015021-pol2qm74 5580 12 organ organ NN cord-015021-pol2qm74 5580 13 for for IN cord-015021-pol2qm74 5580 14 MODS mods NN cord-015021-pol2qm74 5580 15 and and CC cord-015021-pol2qm74 5580 16 injured injured JJ cord-015021-pol2qm74 5580 17 lung lung NN cord-015021-pol2qm74 5580 18 can can MD cord-015021-pol2qm74 5580 19 be be VB cord-015021-pol2qm74 5580 20 the the DT cord-015021-pol2qm74 5580 21 cause cause NN cord-015021-pol2qm74 5580 22 of of IN cord-015021-pol2qm74 5580 23 MODS mods NN cord-015021-pol2qm74 5580 24 or or CC cord-015021-pol2qm74 5580 25 simply simply RB cord-015021-pol2qm74 5580 26 a a DT cord-015021-pol2qm74 5580 27 participant participant NN cord-015021-pol2qm74 5580 28 to to IN cord-015021-pol2qm74 5580 29 this this DT cord-015021-pol2qm74 5580 30 syndrome syndrome NN cord-015021-pol2qm74 5580 31 . . . cord-015021-pol2qm74 5581 1 Jorge Jorge NNP cord-015021-pol2qm74 5581 2 Cervts Cervts NNP cord-015021-pol2qm74 5581 3 - - HYPH cord-015021-pol2qm74 5581 4 Navarro Navarro NNP cord-015021-pol2qm74 5581 5 Main Main NNP cord-015021-pol2qm74 5581 6 determinants determinant NNS cord-015021-pol2qm74 5581 7 for for IN cord-015021-pol2qm74 5581 8 brain brain NN cord-015021-pol2qm74 5581 9 dysfunction dysfunction NN cord-015021-pol2qm74 5581 10 are be VBP cord-015021-pol2qm74 5581 11 breakdown breakdown NN cord-015021-pol2qm74 5581 12 of of IN cord-015021-pol2qm74 5581 13 the the DT cord-015021-pol2qm74 5581 14 blood blood NN cord-015021-pol2qm74 5581 15 - - HYPH cord-015021-pol2qm74 5581 16 brainbarrier brainbarrier NN cord-015021-pol2qm74 5581 17 and and CC cord-015021-pol2qm74 5581 18 raise raise VB cord-015021-pol2qm74 5581 19 of of IN cord-015021-pol2qm74 5581 20 intracranial intracranial JJ cord-015021-pol2qm74 5581 21 pressure pressure NN cord-015021-pol2qm74 5581 22 ( ( -LRB- cord-015021-pol2qm74 5581 23 ICP ICP NNP cord-015021-pol2qm74 5581 24 ) ) -RRB- cord-015021-pol2qm74 5581 25 , , , cord-015021-pol2qm74 5581 26 in in IN cord-015021-pol2qm74 5581 27 second second JJ cord-015021-pol2qm74 5581 28 place place NN cord-015021-pol2qm74 5581 29 decrease decrease NN cord-015021-pol2qm74 5581 30 of of IN cord-015021-pol2qm74 5581 31 systemic systemic JJ cord-015021-pol2qm74 5581 32 blood blood NN cord-015021-pol2qm74 5581 33 pressure pressure NN cord-015021-pol2qm74 5581 34 , , , cord-015021-pol2qm74 5581 35 disorders disorder NNS cord-015021-pol2qm74 5581 36 of of IN cord-015021-pol2qm74 5581 37 blood blood NN cord-015021-pol2qm74 5581 38 coagulation coagulation NN cord-015021-pol2qm74 5581 39 and and CC cord-015021-pol2qm74 5581 40 respiratory respiratory JJ cord-015021-pol2qm74 5581 41 function function NN cord-015021-pol2qm74 5581 42 . . . cord-015021-pol2qm74 5582 1 The the DT cord-015021-pol2qm74 5582 2 blood blood NN cord-015021-pol2qm74 5582 3 - - HYPH cord-015021-pol2qm74 5582 4 brain brain NN cord-015021-pol2qm74 5582 5 - - HYPH cord-015021-pol2qm74 5582 6 barrier barrier NN cord-015021-pol2qm74 5582 7 of of IN cord-015021-pol2qm74 5582 8 cerebral cerebral JJ cord-015021-pol2qm74 5582 9 blood blood NN cord-015021-pol2qm74 5582 10 vessels vessel NNS cord-015021-pol2qm74 5582 11 can can MD cord-015021-pol2qm74 5582 12 be be VB cord-015021-pol2qm74 5582 13 opened open VBN cord-015021-pol2qm74 5582 14 by by IN cord-015021-pol2qm74 5582 15 stroke stroke NN cord-015021-pol2qm74 5582 16 , , , cord-015021-pol2qm74 5582 17 cerebral cerebral JJ cord-015021-pol2qm74 5582 18 trauma trauma NN cord-015021-pol2qm74 5582 19 , , , cord-015021-pol2qm74 5582 20 inflammation inflammation NN cord-015021-pol2qm74 5582 21 , , , cord-015021-pol2qm74 5582 22 convulsions convulsion NNS cord-015021-pol2qm74 5582 23 , , , cord-015021-pol2qm74 5582 24 acute acute JJ cord-015021-pol2qm74 5582 25 hypertension hypertension NN cord-015021-pol2qm74 5582 26 and and CC cord-015021-pol2qm74 5582 27 changes change NNS cord-015021-pol2qm74 5582 28 in in IN cord-015021-pol2qm74 5582 29 the the DT cord-015021-pol2qm74 5582 30 blood blood NN cord-015021-pol2qm74 5582 31 osmolarity osmolarity NN cord-015021-pol2qm74 5582 32 . . . cord-015021-pol2qm74 5583 1 The the DT cord-015021-pol2qm74 5583 2 consequence consequence NN cord-015021-pol2qm74 5583 3 is be VBZ cord-015021-pol2qm74 5583 4 brain brain NN cord-015021-pol2qm74 5583 5 oedema oedema NN cord-015021-pol2qm74 5583 6 , , , cord-015021-pol2qm74 5583 7 increase increase NN cord-015021-pol2qm74 5583 8 of of IN cord-015021-pol2qm74 5583 9 lOP lOP NNS cord-015021-pol2qm74 5583 10 and and CC cord-015021-pol2qm74 5583 11 decrease decrease NN cord-015021-pol2qm74 5583 12 of of IN cord-015021-pol2qm74 5583 13 the the DT cord-015021-pol2qm74 5583 14 perfusion perfusion NN cord-015021-pol2qm74 5583 15 pressure pressure NN cord-015021-pol2qm74 5583 16 . . . cord-015021-pol2qm74 5584 1 A a DT cord-015021-pol2qm74 5584 2 close close JJ cord-015021-pol2qm74 5584 3 correlation correlation NN cord-015021-pol2qm74 5584 4 between between IN cord-015021-pol2qm74 5584 5 intraventricular intraventricular JJ cord-015021-pol2qm74 5584 6 pressure pressure NN cord-015021-pol2qm74 5584 7 and and CC cord-015021-pol2qm74 5584 8 the the DT cord-015021-pol2qm74 5584 9 fate fate NN cord-015021-pol2qm74 5584 10 of of IN cord-015021-pol2qm74 5584 11 patients patient NNS cord-015021-pol2qm74 5584 12 with with IN cord-015021-pol2qm74 5584 13 severe severe JJ cord-015021-pol2qm74 5584 14 brain brain NN cord-015021-pol2qm74 5584 15 injuries injury NNS cord-015021-pol2qm74 5584 16 has have VBZ cord-015021-pol2qm74 5584 17 been be VBN cord-015021-pol2qm74 5584 18 established establish VBN cord-015021-pol2qm74 5584 19 . . . cord-015021-pol2qm74 5585 1 Regional regional JJ cord-015021-pol2qm74 5585 2 CBF CBF NNP cord-015021-pol2qm74 5585 3 values value NNS cord-015021-pol2qm74 5585 4 of of IN cord-015021-pol2qm74 5585 5 16 16 CD cord-015021-pol2qm74 5585 6 to to TO cord-015021-pol2qm74 5585 7 18 18 CD cord-015021-pol2qm74 5585 8 ml/100g ml/100g CD cord-015021-pol2qm74 5585 9 / / SYM cord-015021-pol2qm74 5585 10 min min NN cord-015021-pol2qm74 5585 11 are be VBP cord-015021-pol2qm74 5585 12 reflected reflect VBN cord-015021-pol2qm74 5585 13 in in IN cord-015021-pol2qm74 5585 14 isoelectric isoelectric JJ cord-015021-pol2qm74 5585 15 EEG EEG NNP cord-015021-pol2qm74 5585 16 , , , cord-015021-pol2qm74 5585 17 and and CC cord-015021-pol2qm74 5585 18 values value NNS cord-015021-pol2qm74 5585 19 about about IN cord-015021-pol2qm74 5585 20 t5ml/100g t5ml/100g NN cord-015021-pol2qm74 5585 21 / / SYM cord-015021-pol2qm74 5585 22 min min NN cord-015021-pol2qm74 5585 23 , , , cord-015021-pol2qm74 5585 24 result result VB cord-015021-pol2qm74 5585 25 in in IN cord-015021-pol2qm74 5585 26 loss loss NN cord-015021-pol2qm74 5585 27 of of IN cord-015021-pol2qm74 5585 28 somatosensory somatosensory NN cord-015021-pol2qm74 5585 29 evoked evoke VBN cord-015021-pol2qm74 5585 30 potentials potential NNS cord-015021-pol2qm74 5585 31 . . . cord-015021-pol2qm74 5586 1 For for IN cord-015021-pol2qm74 5586 2 ionic ionic JJ cord-015021-pol2qm74 5586 3 pump pump NN cord-015021-pol2qm74 5586 4 failure failure NN cord-015021-pol2qm74 5586 5 the the DT cord-015021-pol2qm74 5586 6 threshold threshold NN cord-015021-pol2qm74 5586 7 has have VBZ cord-015021-pol2qm74 5586 8 been be VBN cord-015021-pol2qm74 5586 9 determined determine VBN cord-015021-pol2qm74 5586 10 by by IN cord-015021-pol2qm74 5586 11 values value NNS cord-015021-pol2qm74 5586 12 of of IN cord-015021-pol2qm74 5586 13 about about RB cord-015021-pol2qm74 5586 14 10 10 CD cord-015021-pol2qm74 5586 15 ml/100g ml/100g CD cord-015021-pol2qm74 5586 16 / / SYM cord-015021-pol2qm74 5586 17 min min NN cord-015021-pol2qm74 5586 18 and and CC cord-015021-pol2qm74 5586 19 is be VBZ cord-015021-pol2qm74 5586 20 reflected reflect VBN cord-015021-pol2qm74 5586 21 in in IN cord-015021-pol2qm74 5586 22 massive massive JJ cord-015021-pol2qm74 5586 23 release release NN cord-015021-pol2qm74 5586 24 of of IN cord-015021-pol2qm74 5586 25 intracellular intracellular JJ cord-015021-pol2qm74 5586 26 potassium potassium NN cord-015021-pol2qm74 5586 27 . . . cord-015021-pol2qm74 5587 1 In in IN cord-015021-pol2qm74 5587 2 stroke stroke NN cord-015021-pol2qm74 5587 3 and and CC cord-015021-pol2qm74 5587 4 in in IN cord-015021-pol2qm74 5587 5 brain brain NN cord-015021-pol2qm74 5587 6 trauma trauma NN cord-015021-pol2qm74 5587 7 when when WRB cord-015021-pol2qm74 5587 8 the the DT cord-015021-pol2qm74 5587 9 oedematogenous oedematogenous JJ cord-015021-pol2qm74 5587 10 condition condition NN cord-015021-pol2qm74 5587 11 is be VBZ cord-015021-pol2qm74 5587 12 initially initially RB cord-015021-pol2qm74 5587 13 localized localize VBN cord-015021-pol2qm74 5587 14 the the DT cord-015021-pol2qm74 5587 15 tissue tissue NN cord-015021-pol2qm74 5587 16 pressure pressure NN cord-015021-pol2qm74 5587 17 variance variance NN cord-015021-pol2qm74 5587 18 within within IN cord-015021-pol2qm74 5587 19 and and CC cord-015021-pol2qm74 5587 20 between between IN cord-015021-pol2qm74 5587 21 the the DT cord-015021-pol2qm74 5587 22 hemispheres hemisphere NNS cord-015021-pol2qm74 5587 23 lead lead VBP cord-015021-pol2qm74 5587 24 to to IN cord-015021-pol2qm74 5587 25 tentorial tentorial NNP cord-015021-pol2qm74 5587 26 and and CC cord-015021-pol2qm74 5587 27 falciform falciform JJ cord-015021-pol2qm74 5587 28 herniations herniation NNS cord-015021-pol2qm74 5587 29 are be VBP cord-015021-pol2qm74 5587 30 the the DT cord-015021-pol2qm74 5587 31 common common JJ cord-015021-pol2qm74 5587 32 cause cause NN cord-015021-pol2qm74 5587 33 of of IN cord-015021-pol2qm74 5587 34 death death NN cord-015021-pol2qm74 5587 35 even even RB cord-015021-pol2qm74 5587 36 before before IN cord-015021-pol2qm74 5587 37 the the DT cord-015021-pol2qm74 5587 38 critical critical JJ cord-015021-pol2qm74 5587 39 threshold threshold NN cord-015021-pol2qm74 5587 40 of of IN cord-015021-pol2qm74 5587 41 intracranial intracranial JJ cord-015021-pol2qm74 5587 42 pressure pressure NN cord-015021-pol2qm74 5587 43 is be VBZ cord-015021-pol2qm74 5587 44 reached reach VBN cord-015021-pol2qm74 5587 45 . . . cord-015021-pol2qm74 5588 1 The the DT cord-015021-pol2qm74 5588 2 increase increase NN cord-015021-pol2qm74 5588 3 of of IN cord-015021-pol2qm74 5588 4 the the DT cord-015021-pol2qm74 5588 5 ICP ICP NNP cord-015021-pol2qm74 5588 6 over over IN cord-015021-pol2qm74 5588 7 the the DT cord-015021-pol2qm74 5588 8 level level NN cord-015021-pol2qm74 5588 9 of of IN cord-015021-pol2qm74 5588 10 the the DT cord-015021-pol2qm74 5588 11 perfusion perfusion NN cord-015021-pol2qm74 5588 12 pressure pressure NN cord-015021-pol2qm74 5588 13 leads lead VBZ cord-015021-pol2qm74 5588 14 to to IN cord-015021-pol2qm74 5588 15 the the DT cord-015021-pol2qm74 5588 16 arrest arrest NN cord-015021-pol2qm74 5588 17 of of IN cord-015021-pol2qm74 5588 18 the the DT cord-015021-pol2qm74 5588 19 CBF CBF NNP cord-015021-pol2qm74 5588 20 . . . cord-015021-pol2qm74 5589 1 If if IN cord-015021-pol2qm74 5589 2 this this DT cord-015021-pol2qm74 5589 3 persists persist VBZ cord-015021-pol2qm74 5589 4 { { -LRB- cord-015021-pol2qm74 5589 5 or or CC cord-015021-pol2qm74 5589 6 periods period NNS cord-015021-pol2qm74 5589 7 exceeding exceed VBG cord-015021-pol2qm74 5589 8 6 6 CD cord-015021-pol2qm74 5589 9 seconds second NNS cord-015021-pol2qm74 5589 10 of of IN cord-015021-pol2qm74 5589 11 global global JJ cord-015021-pol2qm74 5589 12 brain brain NN cord-015021-pol2qm74 5589 13 ischemia ischemia NN cord-015021-pol2qm74 5589 14 loss loss NN cord-015021-pol2qm74 5589 15 of of IN cord-015021-pol2qm74 5589 16 conciousness conciousness NN cord-015021-pol2qm74 5589 17 and and CC cord-015021-pol2qm74 5589 18 developing develop VBG cord-015021-pol2qm74 5589 19 seizures seizure NNS cord-015021-pol2qm74 5589 20 appear appear VBP cord-015021-pol2qm74 5589 21 . . . cord-015021-pol2qm74 5590 1 If if IN cord-015021-pol2qm74 5590 2 it -PRON- PRP cord-015021-pol2qm74 5590 3 exceeds exceed VBZ cord-015021-pol2qm74 5590 4 10 10 CD cord-015021-pol2qm74 5590 5 min min NN cord-015021-pol2qm74 5590 6 irreversible irreversible JJ cord-015021-pol2qm74 5590 7 injuries injury NNS cord-015021-pol2qm74 5590 8 of of IN cord-015021-pol2qm74 5590 9 the the DT cord-015021-pol2qm74 5590 10 brain brain NN cord-015021-pol2qm74 5590 11 appear appear VBP cord-015021-pol2qm74 5590 12 . . . cord-015021-pol2qm74 5591 1 Following follow VBG cord-015021-pol2qm74 5591 2 cerebral cerebral JJ cord-015021-pol2qm74 5591 3 ischemia ischemia NN cord-015021-pol2qm74 5591 4 and and CC cord-015021-pol2qm74 5591 5 after after IN cord-015021-pol2qm74 5591 6 severe severe JJ cord-015021-pol2qm74 5591 7 head head NN cord-015021-pol2qm74 5591 8 injury injury NN cord-015021-pol2qm74 5591 9 a a DT cord-015021-pol2qm74 5591 10 tendency tendency NN cord-015021-pol2qm74 5591 11 to to IN cord-015021-pol2qm74 5591 12 increased increase VBN cord-015021-pol2qm74 5591 13 coagulation coagulation NN cord-015021-pol2qm74 5591 14 can can MD cord-015021-pol2qm74 5591 15 be be VB cord-015021-pol2qm74 5591 16 detected detect VBN cord-015021-pol2qm74 5591 17 . . . cord-015021-pol2qm74 5592 1 Vascular vascular JJ cord-015021-pol2qm74 5592 2 occlusion occlusion NN cord-015021-pol2qm74 5592 3 may may MD cord-015021-pol2qm74 5592 4 develop develop VB cord-015021-pol2qm74 5592 5 either either CC cord-015021-pol2qm74 5592 6 as as IN cord-015021-pol2qm74 5592 7 a a DT cord-015021-pol2qm74 5592 8 result result NN cord-015021-pol2qm74 5592 9 of of IN cord-015021-pol2qm74 5592 10 local local JJ cord-015021-pol2qm74 5592 11 thrombus thrombus NN cord-015021-pol2qm74 5592 12 formation formation NN cord-015021-pol2qm74 5592 13 or or CC cord-015021-pol2qm74 5592 14 from from IN cord-015021-pol2qm74 5592 15 emboli embolus NNS cord-015021-pol2qm74 5592 16 caused cause VBN cord-015021-pol2qm74 5592 17 by by IN cord-015021-pol2qm74 5592 18 circulating circulate VBG cord-015021-pol2qm74 5592 19 platelet platelet NN cord-015021-pol2qm74 5592 20 aggregates aggregate NNS cord-015021-pol2qm74 5592 21 . . . cord-015021-pol2qm74 5593 1 The the DT cord-015021-pol2qm74 5593 2 formation formation NN cord-015021-pol2qm74 5593 3 of of IN cord-015021-pol2qm74 5593 4 microthrombi microthrombi NNP cord-015021-pol2qm74 5593 5 is be VBZ cord-015021-pol2qm74 5593 6 triggered trigger VBN cord-015021-pol2qm74 5593 7 by by IN cord-015021-pol2qm74 5593 8 the the DT cord-015021-pol2qm74 5593 9 plateletactivating plateletactivating NN cord-015021-pol2qm74 5593 10 factor factor NN cord-015021-pol2qm74 5593 11 a a DT cord-015021-pol2qm74 5593 12 mediator mediator NN cord-015021-pol2qm74 5593 13 in in IN cord-015021-pol2qm74 5593 14 central central JJ cord-015021-pol2qm74 5593 15 nervous nervous JJ cord-015021-pol2qm74 5593 16 injury injury NN cord-015021-pol2qm74 5593 17 also also RB cord-015021-pol2qm74 5593 18 responsible responsible JJ cord-015021-pol2qm74 5593 19 for for IN cord-015021-pol2qm74 5593 20 aggravation aggravation NN cord-015021-pol2qm74 5593 21 of of IN cord-015021-pol2qm74 5593 22 posttraumatic posttraumatic JJ cord-015021-pol2qm74 5593 23 brain brain NN cord-015021-pol2qm74 5593 24 edema edema NN cord-015021-pol2qm74 5593 25 . . . cord-015021-pol2qm74 5594 1 Acute acute JJ cord-015021-pol2qm74 5594 2 hemorrhagic hemorrhagic JJ cord-015021-pol2qm74 5594 3 leucoencephalitis leucoencephalitis NN cord-015021-pol2qm74 5594 4 and and CC cord-015021-pol2qm74 5594 5 brain brain NN cord-015021-pol2qm74 5594 6 purpura purpura NN cord-015021-pol2qm74 5594 7 are be VBP cord-015021-pol2qm74 5594 8 known know VBN cord-015021-pol2qm74 5594 9 to to TO cord-015021-pol2qm74 5594 10 arise arise VB cord-015021-pol2qm74 5594 11 as as IN cord-015021-pol2qm74 5594 12 complications complication NNS cord-015021-pol2qm74 5594 13 of of IN cord-015021-pol2qm74 5594 14 acute acute JJ cord-015021-pol2qm74 5594 15 viral viral JJ cord-015021-pol2qm74 5594 16 infections infection NNS cord-015021-pol2qm74 5594 17 and and CC cord-015021-pol2qm74 5594 18 following follow VBG cord-015021-pol2qm74 5594 19 Gram gram NN cord-015021-pol2qm74 5594 20 - - HYPH cord-015021-pol2qm74 5594 21 negative negative JJ cord-015021-pol2qm74 5594 22 septicaemia septicaemia NN cord-015021-pol2qm74 5594 23 . . . cord-015021-pol2qm74 5595 1 Institute Institute NNP cord-015021-pol2qm74 5595 2 of of IN cord-015021-pol2qm74 5595 3 Neuropathology Neuropathology NNP cord-015021-pol2qm74 5595 4 , , , cord-015021-pol2qm74 5595 5 Free Free NNP cord-015021-pol2qm74 5595 6 University University NNP cord-015021-pol2qm74 5595 7 of of IN cord-015021-pol2qm74 5595 8 Berlin Berlin NNP cord-015021-pol2qm74 5595 9 , , , cord-015021-pol2qm74 5595 10 Hindenburgdamm Hindenburgdamm NNP cord-015021-pol2qm74 5595 11 30 30 CD cord-015021-pol2qm74 5595 12 , , , cord-015021-pol2qm74 5595 13 12200 12200 CD cord-015021-pol2qm74 5595 14 Berlin Berlin NNP cord-015021-pol2qm74 5595 15 , , , cord-015021-pol2qm74 5595 16 Germany Germany NNP cord-015021-pol2qm74 5595 17 Undoubtedly Undoubtedly NNP cord-015021-pol2qm74 5595 18 , , , cord-015021-pol2qm74 5595 19 attempts attempt VBZ cord-015021-pol2qm74 5595 20 to to TO cord-015021-pol2qm74 5595 21 quantify quantify VB cord-015021-pol2qm74 5595 22 as as RB cord-015021-pol2qm74 5595 23 objectively objectively RB cord-015021-pol2qm74 5595 24 as as IN cord-015021-pol2qm74 5595 25 possible possible JJ cord-015021-pol2qm74 5596 1 the the DT cord-015021-pol2qm74 5596 2 degree degree NN cord-015021-pol2qm74 5596 3 of of IN cord-015021-pol2qm74 5596 4 dysfunction dysfunction NN cord-015021-pol2qm74 5596 5 of of IN cord-015021-pol2qm74 5596 6 the the DT cord-015021-pol2qm74 5596 7 various various JJ cord-015021-pol2qm74 5596 8 organs organ NNS cord-015021-pol2qm74 5596 9 is be VBZ cord-015021-pol2qm74 5596 10 very very RB cord-015021-pol2qm74 5596 11 valuable valuable JJ cord-015021-pol2qm74 5596 12 . . . cord-015021-pol2qm74 5597 1 However however RB cord-015021-pol2qm74 5597 2 , , , cord-015021-pol2qm74 5597 3 cardiovascular cardiovascular JJ cord-015021-pol2qm74 5597 4 failure failure NN cord-015021-pol2qm74 5597 5 has have VBZ cord-015021-pol2qm74 5597 6 a a DT cord-015021-pol2qm74 5597 7 peculiar peculiar JJ cord-015021-pol2qm74 5597 8 place place NN cord-015021-pol2qm74 5597 9 in in IN cord-015021-pol2qm74 5597 10 the the DT cord-015021-pol2qm74 5597 11 context context NN cord-015021-pol2qm74 5597 12 of of IN cord-015021-pol2qm74 5597 13 sepsis sepsis NN cord-015021-pol2qm74 5597 14 . . . cord-015021-pol2qm74 5598 1 The the DT cord-015021-pol2qm74 5598 2 development development NN cord-015021-pol2qm74 5598 3 of of IN cord-015021-pol2qm74 5598 4 acute acute JJ cord-015021-pol2qm74 5598 5 circulatory circulatory JJ cord-015021-pol2qm74 5598 6 failure failure NN cord-015021-pol2qm74 5598 7 ( ( -LRB- cord-015021-pol2qm74 5598 8 shock shock NN cord-015021-pol2qm74 5598 9 ) ) -RRB- cord-015021-pol2qm74 5598 10 is be VBZ cord-015021-pol2qm74 5598 11 of of IN cord-015021-pol2qm74 5598 12 paramount paramount JJ cord-015021-pol2qm74 5598 13 importance importance NN cord-015021-pol2qm74 5598 14 as as IN cord-015021-pol2qm74 5598 15 a a DT cord-015021-pol2qm74 5598 16 cause cause NN cord-015021-pol2qm74 5598 17 rather rather RB cord-015021-pol2qm74 5598 18 than than IN cord-015021-pol2qm74 5598 19 as as IN cord-015021-pol2qm74 5598 20 a a DT cord-015021-pol2qm74 5598 21 consequence consequence NN cord-015021-pol2qm74 5598 22 of of IN cord-015021-pol2qm74 5598 23 organ organ NN cord-015021-pol2qm74 5598 24 failure failure NN cord-015021-pol2qm74 5598 25 . . . cord-015021-pol2qm74 5599 1 It -PRON- PRP cord-015021-pol2qm74 5599 2 is be VBZ cord-015021-pol2qm74 5599 3 therefore therefore RB cord-015021-pol2qm74 5599 4 essential essential JJ cord-015021-pol2qm74 5599 5 to to TO cord-015021-pol2qm74 5599 6 clearly clearly RB cord-015021-pol2qm74 5599 7 separate separate VB cord-015021-pol2qm74 5599 8 patients patient NNS cord-015021-pol2qm74 5599 9 with with IN cord-015021-pol2qm74 5599 10 and and CC cord-015021-pol2qm74 5599 11 without without IN cord-015021-pol2qm74 5599 12 circulatory circulatory JJ cord-015021-pol2qm74 5599 13 failure failure NN cord-015021-pol2qm74 5599 14 . . . cord-015021-pol2qm74 5600 1 Once once RB cord-015021-pol2qm74 5600 2 this this DT cord-015021-pol2qm74 5600 3 has have VBZ cord-015021-pol2qm74 5600 4 been be VBN cord-015021-pol2qm74 5600 5 done do VBN cord-015021-pol2qm74 5600 6 , , , cord-015021-pol2qm74 5600 7 attempts attempt VBZ cord-015021-pol2qm74 5600 8 to to TO cord-015021-pol2qm74 5600 9 list list VB cord-015021-pol2qm74 5600 10 the the DT cord-015021-pol2qm74 5600 11 cardiovascular cardiovascular JJ cord-015021-pol2qm74 5600 12 system system NN cord-015021-pol2qm74 5600 13 among among IN cord-015021-pol2qm74 5600 14 the the DT cord-015021-pol2qm74 5600 15 other other JJ cord-015021-pol2qm74 5600 16 systems system NNS cord-015021-pol2qm74 5600 17 have have VBP cord-015021-pol2qm74 5600 18 been be VBN cord-015021-pol2qm74 5600 19 unconvincing unconvincing JJ cord-015021-pol2qm74 5600 20 . . . cord-015021-pol2qm74 5601 1 In in IN cord-015021-pol2qm74 5601 2 a a DT cord-015021-pol2qm74 5601 3 number number NN cord-015021-pol2qm74 5601 4 of of IN cord-015021-pol2qm74 5601 5 studies study NNS cord-015021-pol2qm74 5601 6 , , , cord-015021-pol2qm74 5601 7 cardiovascular cardiovascular JJ cord-015021-pol2qm74 5601 8 complications complication NNS cord-015021-pol2qm74 5601 9 are be VBP cord-015021-pol2qm74 5601 10 assimilated assimilate VBN cord-015021-pol2qm74 5601 11 to to IN cord-015021-pol2qm74 5601 12 a a DT cord-015021-pol2qm74 5601 13 low low JJ cord-015021-pol2qm74 5601 14 systemic systemic JJ cord-015021-pol2qm74 5601 15 vascular vascular JJ cord-015021-pol2qm74 5601 16 resistance resistance NN cord-015021-pol2qm74 5601 17 ( ( -LRB- cord-015021-pol2qm74 5601 18 SVR SVR NNP cord-015021-pol2qm74 5601 19 ) ) -RRB- cord-015021-pol2qm74 5601 20 , , , cord-015021-pol2qm74 5601 21 but but CC cord-015021-pol2qm74 5601 22 since since IN cord-015021-pol2qm74 5601 23 SVR SVR NNP cord-015021-pol2qm74 5601 24 is be VBZ cord-015021-pol2qm74 5601 25 basically basically RB cord-015021-pol2qm74 5601 26 the the DT cord-015021-pol2qm74 5601 27 ratio ratio NN cord-015021-pol2qm74 5601 28 of of IN cord-015021-pol2qm74 5601 29 blood blood NN cord-015021-pol2qm74 5601 30 pressure pressure NN cord-015021-pol2qm74 5601 31 over over IN cord-015021-pol2qm74 5601 32 cardiac cardiac JJ cord-015021-pol2qm74 5601 33 output output NN cord-015021-pol2qm74 5601 34 , , , cord-015021-pol2qm74 5601 35 and and CC cord-015021-pol2qm74 5601 36 since since IN cord-015021-pol2qm74 5601 37 hypotension hypotension NN cord-015021-pol2qm74 5601 38 is be VBZ cord-015021-pol2qm74 5601 39 already already RB cord-015021-pol2qm74 5601 40 included include VBN cord-015021-pol2qm74 5601 41 in in IN cord-015021-pol2qm74 5601 42 the the DT cord-015021-pol2qm74 5601 43 definition definition NN cord-015021-pol2qm74 5601 44 of of IN cord-015021-pol2qm74 5601 45 shock shock NN cord-015021-pol2qm74 5601 46 , , , cord-015021-pol2qm74 5601 47 then then RB cord-015021-pol2qm74 5601 48 a a DT cord-015021-pol2qm74 5601 49 low low JJ cord-015021-pol2qm74 5601 50 SVR SVR NNP cord-015021-pol2qm74 5601 51 is be VBZ cord-015021-pol2qm74 5601 52 basically basically RB cord-015021-pol2qm74 5601 53 equivalent equivalent JJ cord-015021-pol2qm74 5601 54 to to IN cord-015021-pol2qm74 5601 55 a a DT cord-015021-pol2qm74 5601 56 high high JJ cord-015021-pol2qm74 5601 57 cardiac cardiac JJ cord-015021-pol2qm74 5601 58 output output NN cord-015021-pol2qm74 5601 59 , , , cord-015021-pol2qm74 5601 60 which which WDT cord-015021-pol2qm74 5601 61 is be VBZ cord-015021-pol2qm74 5601 62 a a DT cord-015021-pol2qm74 5601 63 characteristic characteristic NN cord-015021-pol2qm74 5601 64 rather rather RB cord-015021-pol2qm74 5601 65 than than IN cord-015021-pol2qm74 5601 66 an an DT cord-015021-pol2qm74 5601 67 ominous ominous JJ cord-015021-pol2qm74 5601 68 complication complication NN cord-015021-pol2qm74 5601 69 of of IN cord-015021-pol2qm74 5601 70 severe severe JJ cord-015021-pol2qm74 5601 71 sepsis sepsis NN cord-015021-pol2qm74 5601 72 . . . cord-015021-pol2qm74 5602 1 Development development NN cord-015021-pol2qm74 5602 2 of of IN cord-015021-pol2qm74 5602 3 a a DT cord-015021-pol2qm74 5602 4 low low JJ cord-015021-pol2qm74 5602 5 cardiac cardiac JJ cord-015021-pol2qm74 5602 6 output output NN cord-015021-pol2qm74 5602 7 unresponsive unresponsive JJ cord-015021-pol2qm74 5602 8 to to IN cord-015021-pol2qm74 5602 9 fluids fluid NNS cord-015021-pol2qm74 5602 10 is be VBZ cord-015021-pol2qm74 5602 11 usually usually RB cord-015021-pol2qm74 5602 12 a a DT cord-015021-pol2qm74 5602 13 terminal terminal JJ cord-015021-pol2qm74 5602 14 event event NN cord-015021-pol2qm74 5602 15 . . . cord-015021-pol2qm74 5603 1 It -PRON- PRP cord-015021-pol2qm74 5603 2 is be VBZ cord-015021-pol2qm74 5603 3 not not RB cord-015021-pol2qm74 5603 4 advisable advisable JJ cord-015021-pol2qm74 5603 5 to to TO cord-015021-pol2qm74 5603 6 list list VB cord-015021-pol2qm74 5603 7 other other JJ cord-015021-pol2qm74 5603 8 problems problem NNS cord-015021-pol2qm74 5603 9 such such JJ cord-015021-pol2qm74 5603 10 as as IN cord-015021-pol2qm74 5603 11 severe severe JJ cord-015021-pol2qm74 5603 12 arrhythmias arrhythmia NNS cord-015021-pol2qm74 5603 13 , , , cord-015021-pol2qm74 5603 14 myocardial myocardial JJ cord-015021-pol2qm74 5603 15 infarction infarction NN cord-015021-pol2qm74 5603 16 or or CC cord-015021-pol2qm74 5603 17 tamponade tamponade NN cord-015021-pol2qm74 5603 18 as as IN cord-015021-pol2qm74 5603 19 complications complication NNS cord-015021-pol2qm74 5603 20 of of IN cord-015021-pol2qm74 5603 21 severe severe JJ cord-015021-pol2qm74 5603 22 sepsis sepsis NN cord-015021-pol2qm74 5603 23 . . . cord-015021-pol2qm74 5604 1 HOST HOST NNP cord-015021-pol2qm74 5604 2 DEFENSE defense NN cord-015021-pol2qm74 5604 3 DYSFUNCTION dysfunction NN cord-015021-pol2qm74 5605 1 FOLLOWING following JJ cord-015021-pol2qm74 5605 2 TRAUMA trauma NN cord-015021-pol2qm74 5605 3 , , , cord-015021-pol2qm74 5606 1 SHOCK shock NN cord-015021-pol2qm74 5606 2 AND and CC cord-015021-pol2qm74 5606 3 SEPSIS SEPSIS NNP cord-015021-pol2qm74 5606 4 E. E. NNP cord-015021-pol2qm74 5606 5 Faist Faist NNP cord-015021-pol2qm74 5606 6 , , , cord-015021-pol2qm74 5606 7 G. G. NNP cord-015021-pol2qm74 5606 8 F. F. NNP cord-015021-pol2qm74 5606 9 Babcock Babcock NNP cord-015021-pol2qm74 5607 1 * * NFP cord-015021-pol2qm74 5608 1 Major major JJ cord-015021-pol2qm74 5608 2 accidental accidental JJ cord-015021-pol2qm74 5608 3 , , , cord-015021-pol2qm74 5608 4 burn burn VB cord-015021-pol2qm74 5608 5 and and CC cord-015021-pol2qm74 5608 6 operative operative JJ cord-015021-pol2qm74 5608 7 injury injury NN cord-015021-pol2qm74 5608 8 often often RB cord-015021-pol2qm74 5608 9 precipitates precipitate VBZ cord-015021-pol2qm74 5608 10 a a DT cord-015021-pol2qm74 5608 11 profound profound JJ cord-015021-pol2qm74 5608 12 multicentric multicentric JJ cord-015021-pol2qm74 5608 13 immunologic immunologic JJ cord-015021-pol2qm74 5608 14 depression depression NN cord-015021-pol2qm74 5608 15 that that WDT cord-015021-pol2qm74 5608 16 is be VBZ cord-015021-pol2qm74 5608 17 believed believe VBN cord-015021-pol2qm74 5608 18 to to TO cord-015021-pol2qm74 5608 19 predispose predispose VB cord-015021-pol2qm74 5608 20 patients patient NNS cord-015021-pol2qm74 5608 21 to to TO cord-015021-pol2qm74 5608 22 become become VB cord-015021-pol2qm74 5608 23 anergic anergic NN cord-015021-pol2qm74 5608 24 and and CC cord-015021-pol2qm74 5608 25 thus thus RB cord-015021-pol2qm74 5608 26 to to TO cord-015021-pol2qm74 5608 27 develop develop VB cord-015021-pol2qm74 5608 28 towards towards IN cord-015021-pol2qm74 5608 29 a a DT cord-015021-pol2qm74 5608 30 higb higb JJ cord-015021-pol2qm74 5608 31 probability probability NN cord-015021-pol2qm74 5608 32 of of IN cord-015021-pol2qm74 5608 33 infection infection NN cord-015021-pol2qm74 5608 34 . . . cord-015021-pol2qm74 5609 1 Anergy Anergy NNP cord-015021-pol2qm74 5609 2 or or CC cord-015021-pol2qm74 5609 3 a a DT cord-015021-pol2qm74 5609 4 lack lack NN cord-015021-pol2qm74 5609 5 of of IN cord-015021-pol2qm74 5609 6 immunologic immunologic JJ cord-015021-pol2qm74 5609 7 reactiVity reactivity NN cord-015021-pol2qm74 5609 8 stands stand VBZ cord-015021-pol2qm74 5609 9 for for IN cord-015021-pol2qm74 5609 10 a a DT cord-015021-pol2qm74 5609 11 total total JJ cord-015021-pol2qm74 5609 12 elimination elimination NN cord-015021-pol2qm74 5609 13 of of IN cord-015021-pol2qm74 5609 14 skin skin NN cord-015021-pol2qm74 5609 15 test test NN cord-015021-pol2qm74 5609 16 reactivity reactivity NN cord-015021-pol2qm74 5609 17 and and CC cord-015021-pol2qm74 5609 18 recall recall VB cord-015021-pol2qm74 5609 19 antigen antigen NN cord-015021-pol2qm74 5609 20 responses response NNS cord-015021-pol2qm74 5609 21 in in IN cord-015021-pol2qm74 5609 22 the the DT cord-015021-pol2qm74 5609 23 inununocompromised inununocompromised JJ cord-015021-pol2qm74 5609 24 patient patient NN cord-015021-pol2qm74 5609 25 . . . cord-015021-pol2qm74 5610 1 Anergy Anergy NNP cord-015021-pol2qm74 5610 2 following follow VBG cord-015021-pol2qm74 5610 3 overwhelming overwhelming JJ cord-015021-pol2qm74 5610 4 trauma trauma NN cord-015021-pol2qm74 5610 5 or or CC cord-015021-pol2qm74 5610 6 major major JJ cord-015021-pol2qm74 5610 7 septic septic JJ cord-015021-pol2qm74 5610 8 conditions condition NNS cord-015021-pol2qm74 5610 9 results result VBZ cord-015021-pol2qm74 5610 10 from from IN cord-015021-pol2qm74 5610 11 a a DT cord-015021-pol2qm74 5610 12 massive massive JJ cord-015021-pol2qm74 5610 13 impairment impairment NN cord-015021-pol2qm74 5610 14 of of IN cord-015021-pol2qm74 5610 15 cell cell NN cord-015021-pol2qm74 5610 16 mediated mediate VBN cord-015021-pol2qm74 5610 17 immunity immunity NN cord-015021-pol2qm74 5610 18 ( ( -LRB- cord-015021-pol2qm74 5610 19 CMI CMI NNP cord-015021-pol2qm74 5610 20 ) ) -RRB- cord-015021-pol2qm74 5610 21 together together RB cord-015021-pol2qm74 5610 22 with with IN cord-015021-pol2qm74 5610 23 a a DT cord-015021-pol2qm74 5610 24 whole whole JJ cord-015021-pol2qm74 5610 25 body body NN cord-015021-pol2qm74 5610 26 malignant malignant JJ cord-015021-pol2qm74 5610 27 inflammationiike inflammationiike JJ cord-015021-pol2qm74 5610 28 state state NN cord-015021-pol2qm74 5610 29 . . . cord-015021-pol2qm74 5611 1 We -PRON- PRP cord-015021-pol2qm74 5611 2 and and CC cord-015021-pol2qm74 5611 3 others other NNS cord-015021-pol2qm74 5611 4 have have VBP cord-015021-pol2qm74 5611 5 demonstrated demonstrate VBN cord-015021-pol2qm74 5611 6 clearly clearly RB cord-015021-pol2qm74 5611 7 that that IN cord-015021-pol2qm74 5611 8 the the DT cord-015021-pol2qm74 5611 9 skeration skeration NN cord-015021-pol2qm74 5611 10 of of IN cord-015021-pol2qm74 5611 11 CMI CMI NNP cord-015021-pol2qm74 5611 12 following follow VBG cord-015021-pol2qm74 5611 13 trauma trauma NN cord-015021-pol2qm74 5611 14 is be VBZ cord-015021-pol2qm74 5611 15 mainly mainly RB cord-015021-pol2qm74 5611 16 due due JJ cord-015021-pol2qm74 5611 17 to to IN cord-015021-pol2qm74 5611 18 the the DT cord-015021-pol2qm74 5611 19 disruption disruption NN cord-015021-pol2qm74 5611 20 of of IN cord-015021-pol2qm74 5611 21 intact intact JJ cord-015021-pol2qm74 5611 22 monocyte monocyte NNP cord-015021-pol2qm74 5611 23 ( ( -LRB- cord-015021-pol2qm74 5611 24 MOO MOO NNP cord-015021-pol2qm74 5611 25 ) ) -RRB- cord-015021-pol2qm74 5611 26 / / SYM cord-015021-pol2qm74 5611 27 T t NN cord-015021-pol2qm74 5611 28 - - HYPH cord-015021-pol2qm74 5611 29 cell cell NN cord-015021-pol2qm74 5611 30 interaction interaction NN cord-015021-pol2qm74 5611 31 . . . cord-015021-pol2qm74 5612 1 Within within IN cord-015021-pol2qm74 5612 2 this this DT cord-015021-pol2qm74 5612 3 phenomenon phenomenon NN cord-015021-pol2qm74 5612 4 we -PRON- PRP cord-015021-pol2qm74 5612 5 see see VBP cord-015021-pol2qm74 5612 6 a a DT cord-015021-pol2qm74 5612 7 shift shift NN cord-015021-pol2qm74 5612 8 of of IN cord-015021-pol2qm74 5612 9 the the DT cord-015021-pol2qm74 5612 10 cell cell NN cord-015021-pol2qm74 5612 11 ratio ratio NN cord-015021-pol2qm74 5612 12 in in IN cord-015021-pol2qm74 5612 13 the the DT cord-015021-pol2qm74 5612 14 compartment compartment NN cord-015021-pol2qm74 5612 15 of of IN cord-015021-pol2qm74 5612 16 peripheral peripheral JJ cord-015021-pol2qm74 5612 17 blood blood NN cord-015021-pol2qm74 5612 18 mononuclear mononuclear NN cord-015021-pol2qm74 5612 19 cells cell NNS cord-015021-pol2qm74 5612 20 ( ( -LRB- cord-015021-pol2qm74 5612 21 PBMC PBMC NNP cord-015021-pol2qm74 5612 22 ) ) -RRB- cord-015021-pol2qm74 5612 23 with with IN cord-015021-pol2qm74 5612 24 a a DT cord-015021-pol2qm74 5612 25 considerable considerable JJ cord-015021-pol2qm74 5612 26 increase increase NN cord-015021-pol2qm74 5612 27 of of IN cord-015021-pol2qm74 5612 28 prostaglandin prostaglandin NN cord-015021-pol2qm74 5612 29 E e NN cord-015021-pol2qm74 5612 30 2 2 CD cord-015021-pol2qm74 5612 31 synthesizing synthesize VBG cord-015021-pol2qm74 5612 32 M~ m~ NN cord-015021-pol2qm74 5612 33 and and CC cord-015021-pol2qm74 5612 34 a a DT cord-015021-pol2qm74 5612 35 simultaneous simultaneous JJ cord-015021-pol2qm74 5612 36 decrease decrease NN cord-015021-pol2qm74 5612 37 of of IN cord-015021-pol2qm74 5612 38 functionally functionally RB cord-015021-pol2qm74 5612 39 competent competent JJ cord-015021-pol2qm74 5612 40 CD3 CD3 NNP cord-015021-pol2qm74 5612 41 + + CC cord-015021-pol2qm74 5612 42 and and CC cord-015021-pol2qm74 5612 43 CD4 CD4 NNP cord-015021-pol2qm74 5612 44 + + CC cord-015021-pol2qm74 5612 45 lymphocytes lymphocyte NNS cord-015021-pol2qm74 5612 46 . . . cord-015021-pol2qm74 5613 1 T t NN cord-015021-pol2qm74 5613 2 - - HYPH cord-015021-pol2qm74 5613 3 cell cell NN cord-015021-pol2qm74 5613 4 dysfunction dysfunction NN cord-015021-pol2qm74 5613 5 in in IN cord-015021-pol2qm74 5613 6 states state NNS cord-015021-pol2qm74 5613 7 of of IN cord-015021-pol2qm74 5613 8 profound profound JJ cord-015021-pol2qm74 5613 9 stress stress NN cord-015021-pol2qm74 5613 10 is be VBZ cord-015021-pol2qm74 5613 11 characterized characterize VBN cord-015021-pol2qm74 5613 12 by by IN cord-015021-pol2qm74 5613 13 impaired impaired JJ cord-015021-pol2qm74 5613 14 synthesis synthesis NN cord-015021-pol2qm74 5613 15 of of IN cord-015021-pol2qm74 5613 16 two two CD cord-015021-pol2qm74 5613 17 crucial crucial JJ cord-015021-pol2qm74 5613 18 lymphokines lymphokine NNS cord-015021-pol2qm74 5613 19 -Interleukin-2 -Interleukin-2 . cord-015021-pol2qm74 5613 20 ( ( -LRB- cord-015021-pol2qm74 5613 21 IL-2 IL-2 NNP cord-015021-pol2qm74 5613 22 ) ) -RRB- cord-015021-pol2qm74 5613 23 and and CC cord-015021-pol2qm74 5613 24 gamma gamma NN cord-015021-pol2qm74 5613 25 - - HYPH cord-015021-pol2qm74 5613 26 Interferon Interferon NNP cord-015021-pol2qm74 5613 27 ( ( -LRB- cord-015021-pol2qm74 5613 28 y y NNP cord-015021-pol2qm74 5613 29 - - HYPH cord-015021-pol2qm74 5613 30 IFN IFN NNP cord-015021-pol2qm74 5613 31 ) ) -RRB- cord-015021-pol2qm74 5613 32 . . . cord-015021-pol2qm74 5614 1 The the DT cord-015021-pol2qm74 5614 2 inability inability NN cord-015021-pol2qm74 5614 3 to to TO cord-015021-pol2qm74 5614 4 produce produce VB cord-015021-pol2qm74 5614 5 adequate adequate JJ cord-015021-pol2qm74 5614 6 amounts amount NNS cord-015021-pol2qm74 5614 7 of of IN cord-015021-pol2qm74 5614 8 IL-2 il-2 NN cord-015021-pol2qm74 5614 9 , , , cord-015021-pol2qm74 5614 10 most most RBS cord-015021-pol2qm74 5614 11 likely likely RB cord-015021-pol2qm74 5614 12 attributable attributable JJ cord-015021-pol2qm74 5614 13 to to IN cord-015021-pol2qm74 5614 14 alterations alteration NNS cord-015021-pol2qm74 5614 15 in in IN cord-015021-pol2qm74 5614 16 the the DT cord-015021-pol2qm74 5614 17 transmission transmission NN cord-015021-pol2qm74 5614 18 of of IN cord-015021-pol2qm74 5614 19 signals signal NNS cord-015021-pol2qm74 5614 20 from from IN cord-015021-pol2qm74 5614 21 the the DT cord-015021-pol2qm74 5614 22 cell cell NN cord-015021-pol2qm74 5614 23 membrane membrane NN cord-015021-pol2qm74 5614 24 to to IN cord-015021-pol2qm74 5614 25 the the DT cord-015021-pol2qm74 5614 26 nucleus nucleus NN cord-015021-pol2qm74 5614 27 , , , cord-015021-pol2qm74 5614 28 results result NNS cord-015021-pol2qm74 5614 29 in in IN cord-015021-pol2qm74 5614 30 incomplete incomplete JJ cord-015021-pol2qm74 5614 31 proliferative proliferative JJ cord-015021-pol2qm74 5614 32 T t NN cord-015021-pol2qm74 5614 33 - - HYPH cord-015021-pol2qm74 5614 34 cell cell NN cord-015021-pol2qm74 5614 35 responses response NNS cord-015021-pol2qm74 5614 36 to to IN cord-015021-pol2qm74 5614 37 antigenic antigenic JJ cord-015021-pol2qm74 5614 38 stimuli stimulus NNS cord-015021-pol2qm74 5614 39 , , , cord-015021-pol2qm74 5614 40 while while IN cord-015021-pol2qm74 5614 41 a a DT cord-015021-pol2qm74 5614 42 lack lack NN cord-015021-pol2qm74 5614 43 of of IN cord-015021-pol2qm74 5614 44 ? ? . cord-015021-pol2qm74 5615 1 -IFN -IFN -LRB- cord-015021-pol2qm74 5615 2 results result VBZ cord-015021-pol2qm74 5615 3 in in IN cord-015021-pol2qm74 5615 4 inadequate inadequate JJ cord-015021-pol2qm74 5615 5 M~ M~ NNP cord-015021-pol2qm74 5615 6 antigen antigen NN cord-015021-pol2qm74 5615 7 processing processing NN cord-015021-pol2qm74 5615 8 and and CC cord-015021-pol2qm74 5615 9 presentation presentation NN cord-015021-pol2qm74 5615 10 . . . cord-015021-pol2qm74 5616 1 The the DT cord-015021-pol2qm74 5616 2 role role NN cord-015021-pol2qm74 5616 3 of of IN cord-015021-pol2qm74 5616 4 the the DT cord-015021-pol2qm74 5616 5 two two CD cord-015021-pol2qm74 5616 6 functionally functionally RB cord-015021-pol2qm74 5616 7 distinct distinct JJ cord-015021-pol2qm74 5616 8 T t NN cord-015021-pol2qm74 5616 9 - - HYPH cord-015021-pol2qm74 5616 10 helper helper NN cord-015021-pol2qm74 5616 11 subsets subset NNS cord-015021-pol2qm74 5616 12 , , , cord-015021-pol2qm74 5616 13 T T NNP cord-015021-pol2qm74 5616 14 - - HYPH cord-015021-pol2qm74 5616 15 helper-1 helper-1 NNP cord-015021-pol2qm74 5617 1 ( ( -LRB- cord-015021-pol2qm74 5617 2 Thl Thl NNP cord-015021-pol2qm74 5617 3 ) ) -RRB- cord-015021-pol2qm74 5617 4 secreting secrete VBG cord-015021-pol2qm74 5617 5 principally principally RB cord-015021-pol2qm74 5617 6 IL-2 IL-2 NNP cord-015021-pol2qm74 5618 1 and and CC cord-015021-pol2qm74 5618 2 ? ? . cord-015021-pol2qm74 5618 3 -IFN -ifn ADD cord-015021-pol2qm74 5618 4 and and CC cord-015021-pol2qm74 5618 5 T T NNP cord-015021-pol2qm74 5618 6 - - HYPH cord-015021-pol2qm74 5618 7 helper-2 helper-2 NNP cord-015021-pol2qm74 5618 8 ( ( -LRB- cord-015021-pol2qm74 5618 9 Th2 Th2 NNP cord-015021-pol2qm74 5618 10 ) ) -RRB- cord-015021-pol2qm74 5618 11 acting act VBG cord-015021-pol2qm74 5618 12 principally principally RB cord-015021-pol2qm74 5618 13 in in IN cord-015021-pol2qm74 5618 14 inducing induce VBG cord-015021-pol2qm74 5618 15 antibody antibody NN cord-015021-pol2qm74 5618 16 formation formation NN cord-015021-pol2qm74 5618 17 with with IN cord-015021-pol2qm74 5618 18 a a DT cord-015021-pol2qm74 5618 19 secretion secretion NN cord-015021-pol2qm74 5618 20 of of IN cord-015021-pol2qm74 5618 21 IL-4 IL-4 NNP cord-015021-pol2qm74 5618 22 , , , cord-015021-pol2qm74 5618 23 IL-5 IL-5 NNP cord-015021-pol2qm74 5618 24 , , , cord-015021-pol2qm74 5618 25 IL-10 IL-10 NNP cord-015021-pol2qm74 5618 26 and and CC cord-015021-pol2qm74 5618 27 TNF-[3 TNF-[3 NNP cord-015021-pol2qm74 5618 28 has have VBZ cord-015021-pol2qm74 5618 29 still still RB cord-015021-pol2qm74 5618 30 to to TO cord-015021-pol2qm74 5618 31 be be VB cord-015021-pol2qm74 5618 32 established establish VBN cord-015021-pol2qm74 5618 33 within within IN cord-015021-pol2qm74 5618 34 the the DT cord-015021-pol2qm74 5618 35 context context NN cord-015021-pol2qm74 5618 36 of of IN cord-015021-pol2qm74 5618 37 major major JJ cord-015021-pol2qm74 5618 38 trauma trauma NN cord-015021-pol2qm74 5618 39 . . . cord-015021-pol2qm74 5619 1 Antibody antibody NN cord-015021-pol2qm74 5619 2 formation formation NN cord-015021-pol2qm74 5619 3 to to IN cord-015021-pol2qm74 5619 4 common common JJ cord-015021-pol2qm74 5619 5 protein protein NN cord-015021-pol2qm74 5619 6 antigens antigen NNS cord-015021-pol2qm74 5619 7 is be VBZ cord-015021-pol2qm74 5619 8 impaired impair VBN cord-015021-pol2qm74 5619 9 , , , cord-015021-pol2qm74 5619 10 the the DT cord-015021-pol2qm74 5619 11 predominant predominant JJ cord-015021-pol2qm74 5619 12 finding finding NN cord-015021-pol2qm74 5619 13 is be VBZ cord-015021-pol2qm74 5619 14 a a DT cord-015021-pol2qm74 5619 15 shift shift NN cord-015021-pol2qm74 5619 16 from from IN cord-015021-pol2qm74 5619 17 IgM IgM NNP cord-015021-pol2qm74 5619 18 to to IN cord-015021-pol2qm74 5619 19 IgG IgG NNP cord-015021-pol2qm74 5619 20 synthesis synthesis NNP cord-015021-pol2qm74 5619 21 . . . cord-015021-pol2qm74 5620 1 Although although IN cord-015021-pol2qm74 5620 2 excessive excessive JJ cord-015021-pol2qm74 5620 3 secretion secretion NN cord-015021-pol2qm74 5620 4 of of IN cord-015021-pol2qm74 5620 5 prninflammatory prninflammatory NN cord-015021-pol2qm74 5620 6 cytokines cytokine NNS cord-015021-pol2qm74 5620 7 ( ( -LRB- cord-015021-pol2qm74 5620 8 IL IL NNP cord-015021-pol2qm74 5620 9 - - HYPH cord-015021-pol2qm74 5620 10 U3 U3 NNP cord-015021-pol2qm74 5620 11 , , , cord-015021-pol2qm74 5620 12 TNF TNF NNP cord-015021-pol2qm74 5620 13 - - HYPH cord-015021-pol2qm74 5620 14 c~ c~ NNP cord-015021-pol2qm74 5620 15 , , , cord-015021-pol2qm74 5620 16 IL-6 IL-6 NNP cord-015021-pol2qm74 5620 17 , , , cord-015021-pol2qm74 5620 18 IL-8 IL-8 NNP cord-015021-pol2qm74 5620 19 ) ) -RRB- cord-015021-pol2qm74 5620 20 has have VBZ cord-015021-pol2qm74 5620 21 been be VBN cord-015021-pol2qm74 5620 22 considered consider VBN cord-015021-pol2qm74 5620 23 to to TO cord-015021-pol2qm74 5620 24 be be VB cord-015021-pol2qm74 5620 25 deleterious deleterious JJ cord-015021-pol2qm74 5620 26 for for IN cord-015021-pol2qm74 5620 27 the the DT cord-015021-pol2qm74 5620 28 host host NN cord-015021-pol2qm74 5620 29 in in IN cord-015021-pol2qm74 5620 30 states state NNS cord-015021-pol2qm74 5620 31 of of IN cord-015021-pol2qm74 5620 32 major major JJ cord-015021-pol2qm74 5620 33 inflammation inflammation NN cord-015021-pol2qm74 5620 34 and and CC cord-015021-pol2qm74 5620 35 infection infection NN cord-015021-pol2qm74 5620 36 , , , cord-015021-pol2qm74 5620 37 in in IN cord-015021-pol2qm74 5620 38 - - HYPH cord-015021-pol2qm74 5620 39 vitro vitro FW cord-015021-pol2qm74 5620 40 and and CC cord-015021-pol2qm74 5620 41 whole whole JJ cord-015021-pol2qm74 5620 42 blood blood NN cord-015021-pol2qm74 5620 43 investigation investigation NN cord-015021-pol2qm74 5620 44 of of IN cord-015021-pol2qm74 5620 45 Me Me NNP cord-015021-pol2qm74 5620 46 function function NN cord-015021-pol2qm74 5620 47 has have VBZ cord-015021-pol2qm74 5620 48 clearly clearly RB cord-015021-pol2qm74 5620 49 revealed reveal VBN cord-015021-pol2qm74 5620 50 that that IN cord-015021-pol2qm74 5620 51 there there EX cord-015021-pol2qm74 5620 52 is be VBZ cord-015021-pol2qm74 5620 53 initially initially RB cord-015021-pol2qm74 5620 54 a a DT cord-015021-pol2qm74 5620 55 marked marked JJ cord-015021-pol2qm74 5620 56 suppression suppression NN cord-015021-pol2qm74 5620 57 of of IN cord-015021-pol2qm74 5620 58 MOO MOO NNP cord-015021-pol2qm74 5620 59 from from IN cord-015021-pol2qm74 5620 60 septic septic JJ cord-015021-pol2qm74 5620 61 patients patient NNS cord-015021-pol2qm74 5620 62 to to TO cord-015021-pol2qm74 5620 63 synthesize synthesize VB cord-015021-pol2qm74 5620 64 and and CC cord-015021-pol2qm74 5620 65 secrete secrete VB cord-015021-pol2qm74 5620 66 proinflammatory proinflammatory JJ cord-015021-pol2qm74 5620 67 cytokines cytokine NNS cord-015021-pol2qm74 5620 68 to to IN cord-015021-pol2qm74 5620 69 endotoxin endotoxin NN cord-015021-pol2qm74 5620 70 . . . cord-015021-pol2qm74 5621 1 This this DT cord-015021-pol2qm74 5621 2 probably probably RB cord-015021-pol2qm74 5621 3 will will MD cord-015021-pol2qm74 5621 4 result result VB cord-015021-pol2qm74 5621 5 in in IN cord-015021-pol2qm74 5621 6 immunodeficiency immunodeficiency NN cord-015021-pol2qm74 5621 7 of of IN cord-015021-pol2qm74 5621 8 traumatized traumatize VBN cord-015021-pol2qm74 5621 9 as as RB cord-015021-pol2qm74 5621 10 well well RB cord-015021-pol2qm74 5621 11 as as IN cord-015021-pol2qm74 5621 12 septic septic JJ cord-015021-pol2qm74 5621 13 patients patient NNS cord-015021-pol2qm74 5621 14 , , , cord-015021-pol2qm74 5621 15 since since IN cord-015021-pol2qm74 5621 16 these these DT cord-015021-pol2qm74 5621 17 cytokines cytokine NNS cord-015021-pol2qm74 5621 18 in in IN cord-015021-pol2qm74 5621 19 low low JJ cord-015021-pol2qm74 5621 20 concentrations concentration NNS cord-015021-pol2qm74 5621 21 are be VBP cord-015021-pol2qm74 5621 22 involved involve VBN cord-015021-pol2qm74 5621 23 in in IN cord-015021-pol2qm74 5621 24 the the DT cord-015021-pol2qm74 5621 25 upregulation upregulation NN cord-015021-pol2qm74 5621 26 of of IN cord-015021-pol2qm74 5621 27 the the DT cord-015021-pol2qm74 5621 28 essential essential JJ cord-015021-pol2qm74 5621 29 humoral humoral JJ cord-015021-pol2qm74 5621 30 and and CC cord-015021-pol2qm74 5621 31 cellular cellular JJ cord-015021-pol2qm74 5621 32 immune immune JJ cord-015021-pol2qm74 5621 33 functions function NNS cord-015021-pol2qm74 5621 34 . . . cord-015021-pol2qm74 5622 1 Abnormalities abnormality NNS cord-015021-pol2qm74 5622 2 of of IN cord-015021-pol2qm74 5622 3 PMN PMN NNP cord-015021-pol2qm74 5622 4 function function NN cord-015021-pol2qm74 5622 5 noted note VBN cord-015021-pol2qm74 5622 6 after after IN cord-015021-pol2qm74 5622 7 serious serious JJ cord-015021-pol2qm74 5622 8 injury injury NN cord-015021-pol2qm74 5622 9 have have VBP cord-015021-pol2qm74 5622 10 been be VBN cord-015021-pol2qm74 5622 11 interpreted interpret VBN cord-015021-pol2qm74 5622 12 by by IN cord-015021-pol2qm74 5622 13 some some DT cord-015021-pol2qm74 5622 14 investigators investigator NNS cord-015021-pol2qm74 5622 15 as as IN cord-015021-pol2qm74 5622 16 signs sign NNS cord-015021-pol2qm74 5622 17 of of IN cord-015021-pol2qm74 5622 18 unresponsiveness unresponsiveness NN cord-015021-pol2qm74 5622 19 of of IN cord-015021-pol2qm74 5622 20 this this DT cord-015021-pol2qm74 5622 21 cell cell NN cord-015021-pol2qm74 5622 22 population population NN cord-015021-pol2qm74 5622 23 , , , cord-015021-pol2qm74 5622 24 others other NNS cord-015021-pol2qm74 5622 25 have have VBP cord-015021-pol2qm74 5622 26 demonstrated demonstrate VBN cord-015021-pol2qm74 5622 27 signs sign NNS cord-015021-pol2qm74 5622 28 of of IN cord-015021-pol2qm74 5622 29 PMN PMN NNP cord-015021-pol2qm74 5622 30 byperactivation byperactivation NN cord-015021-pol2qm74 5622 31 . . . cord-015021-pol2qm74 5623 1 Latest late JJS cord-015021-pol2qm74 5623 2 findings finding NNS cord-015021-pol2qm74 5623 3 revealed reveal VBD cord-015021-pol2qm74 5623 4 that that IN cord-015021-pol2qm74 5623 5 there there EX cord-015021-pol2qm74 5623 6 is be VBZ cord-015021-pol2qm74 5623 7 a a DT cord-015021-pol2qm74 5623 8 clear clear JJ cord-015021-pol2qm74 5623 9 PMN PMN NNP cord-015021-pol2qm74 5623 10 dysfunction dysfunction NN cord-015021-pol2qm74 5623 11 in in IN cord-015021-pol2qm74 5623 12 circulating circulate VBG cord-015021-pol2qm74 5623 13 blood blood NN cord-015021-pol2qm74 5623 14 : : : cord-015021-pol2qm74 5623 15 70 70 CD cord-015021-pol2qm74 5623 16 % % NN cord-015021-pol2qm74 5623 17 of of IN cord-015021-pol2qm74 5623 18 all all DT cord-015021-pol2qm74 5623 19 PMN PMN NNP cord-015021-pol2qm74 5623 20 's 's POS cord-015021-pol2qm74 5623 21 in in IN cord-015021-pol2qm74 5623 22 this this DT cord-015021-pol2qm74 5623 23 compartment compartment NN cord-015021-pol2qm74 5623 24 show show NN cord-015021-pol2qm74 5623 25 downregulated downregulate VBD cord-015021-pol2qm74 5623 26 or or CC cord-015021-pol2qm74 5623 27 non non AFX cord-015021-pol2qm74 5623 28 existent existent JJ cord-015021-pol2qm74 5623 29 ~-integrins ~-integrin NNS cord-015021-pol2qm74 5623 30 within within IN cord-015021-pol2qm74 5623 31 72 72 CD cord-015021-pol2qm74 5623 32 hours hour NNS cord-015021-pol2qm74 5623 33 posttrauma posttrauma NN cord-015021-pol2qm74 5623 34 -these -these JJ cord-015021-pol2qm74 5623 35 cells cell NNS cord-015021-pol2qm74 5623 36 do do VBP cord-015021-pol2qm74 5623 37 not not RB cord-015021-pol2qm74 5623 38 phagocytose phagocytose JJ cord-015021-pol2qm74 5623 39 , , , cord-015021-pol2qm74 5623 40 have have VBP cord-015021-pol2qm74 5623 41 a a DT cord-015021-pol2qm74 5623 42 reduced reduce VBN cord-015021-pol2qm74 5623 43 respiratory respiratory JJ cord-015021-pol2qm74 5623 44 burst burst NN cord-015021-pol2qm74 5623 45 and and CC cord-015021-pol2qm74 5623 46 appear appear VB cord-015021-pol2qm74 5623 47 to to TO cord-015021-pol2qm74 5623 48 be be VB cord-015021-pol2qm74 5623 49 completely completely RB cord-015021-pol2qm74 5623 50 degranulated degranulate VBN cord-015021-pol2qm74 5623 51 . . . cord-015021-pol2qm74 5624 1 Restoration restoration NN cord-015021-pol2qm74 5624 2 of of IN cord-015021-pol2qm74 5624 3 these these DT cord-015021-pol2qm74 5624 4 cell cell NN cord-015021-pol2qm74 5624 5 functions function NNS cord-015021-pol2qm74 5624 6 within within IN cord-015021-pol2qm74 5624 7 7 7 CD cord-015021-pol2qm74 5624 8 days day NNS cord-015021-pol2qm74 5624 9 post post NN cord-015021-pol2qm74 5624 10 - - NN cord-015021-pol2qm74 5624 11 trauma trauma NN cord-015021-pol2qm74 5624 12 is be VBZ cord-015021-pol2qm74 5624 13 significantly significantly RB cord-015021-pol2qm74 5624 14 correlated correlate VBN cord-015021-pol2qm74 5624 15 to to IN cord-015021-pol2qm74 5624 16 survival survival NN cord-015021-pol2qm74 5624 17 of of IN cord-015021-pol2qm74 5624 18 traumatized traumatize VBN cord-015021-pol2qm74 5624 19 patients patient NNS cord-015021-pol2qm74 5624 20 . . . cord-015021-pol2qm74 5625 1 Other other JJ cord-015021-pol2qm74 5625 2 reports report NNS cord-015021-pol2qm74 5625 3 however however RB cord-015021-pol2qm74 5625 4 stress stress NN cord-015021-pol2qm74 5625 5 increased increase VBD cord-015021-pol2qm74 5625 6 expression expression NN cord-015021-pol2qm74 5625 7 of of IN cord-015021-pol2qm74 5625 8 CR3 CR3 NNP cord-015021-pol2qm74 5625 9 + + SYM cord-015021-pol2qm74 5625 10 receptors receptor NNS cord-015021-pol2qm74 5625 11 ( ( -LRB- cord-015021-pol2qm74 5625 12 CDll CDll NNP cord-015021-pol2qm74 5625 13 / / SYM cord-015021-pol2qm74 5625 14 CD18 CD18 NNP cord-015021-pol2qm74 5625 15 complex complex NN cord-015021-pol2qm74 5625 16 ) ) -RRB- cord-015021-pol2qm74 5625 17 on on IN cord-015021-pol2qm74 5625 18 circulating circulate VBG cord-015021-pol2qm74 5625 19 PMN PMN NNP cord-015021-pol2qm74 5625 20 's 's POS cord-015021-pol2qm74 5625 21 , , , cord-015021-pol2qm74 5625 22 increasing increase VBG cord-015021-pol2qm74 5625 23 the the DT cord-015021-pol2qm74 5625 24 ability ability NN cord-015021-pol2qm74 5625 25 of of IN cord-015021-pol2qm74 5625 26 these these DT cord-015021-pol2qm74 5625 27 cells cell NNS cord-015021-pol2qm74 5625 28 to to TO cord-015021-pol2qm74 5625 29 adhere adhere VB cord-015021-pol2qm74 5625 30 to to IN cord-015021-pol2qm74 5625 31 intercellular intercellular JJ cord-015021-pol2qm74 5625 32 adhesion adhesion NN cord-015021-pol2qm74 5625 33 molecules molecule NNS cord-015021-pol2qm74 5625 34 , , , cord-015021-pol2qm74 5625 35 thus thus RB cord-015021-pol2qm74 5625 36 contributing contribute VBG cord-015021-pol2qm74 5625 37 to to TO cord-015021-pol2qm74 5625 38 play play VB cord-015021-pol2qm74 5625 39 a a DT cord-015021-pol2qm74 5625 40 major major JJ cord-015021-pol2qm74 5625 41 role role NN cord-015021-pol2qm74 5625 42 in in IN cord-015021-pol2qm74 5625 43 inducing induce VBG cord-015021-pol2qm74 5625 44 the the DT cord-015021-pol2qm74 5625 45 pulmonary pulmonary JJ cord-015021-pol2qm74 5625 46 capillary capillary JJ cord-015021-pol2qm74 5625 47 leakage leakage NN cord-015021-pol2qm74 5625 48 . . . cord-015021-pol2qm74 5626 1 Our -PRON- PRP$ cord-015021-pol2qm74 5626 2 knowledge knowledge NN cord-015021-pol2qm74 5626 3 about about IN cord-015021-pol2qm74 5626 4 the the DT cord-015021-pol2qm74 5626 5 perturbation perturbation NN cord-015021-pol2qm74 5626 6 of of IN cord-015021-pol2qm74 5626 7 host host NN cord-015021-pol2qm74 5626 8 defenses defense NNS cord-015021-pol2qm74 5626 9 associated associate VBN cord-015021-pol2qm74 5626 10 with with IN cord-015021-pol2qm74 5626 11 serious serious JJ cord-015021-pol2qm74 5626 12 injury injury NN cord-015021-pol2qm74 5626 13 and and CC cord-015021-pol2qm74 5626 14 sepsis sepsis NN cord-015021-pol2qm74 5626 15 is be VBZ cord-015021-pol2qm74 5626 16 continuously continuously RB cord-015021-pol2qm74 5626 17 increasing increase VBG cord-015021-pol2qm74 5626 18 and and CC cord-015021-pol2qm74 5626 19 represents represent VBZ cord-015021-pol2qm74 5626 20 the the DT cord-015021-pol2qm74 5626 21 precondition precondition NN cord-015021-pol2qm74 5626 22 for for IN cord-015021-pol2qm74 5626 23 the the DT cord-015021-pol2qm74 5626 24 design design NN cord-015021-pol2qm74 5626 25 of of IN cord-015021-pol2qm74 5626 26 effective effective JJ cord-015021-pol2qm74 5626 27 therapeutic therapeutic JJ cord-015021-pol2qm74 5626 28 measures measure NNS cord-015021-pol2qm74 5626 29 to to TO cord-015021-pol2qm74 5626 30 prevent prevent VB cord-015021-pol2qm74 5626 31 and and CC cord-015021-pol2qm74 5626 32 counteract counteract VB cord-015021-pol2qm74 5626 33 the the DT cord-015021-pol2qm74 5626 34 resistance resistance NN cord-015021-pol2qm74 5626 35 to to IN cord-015021-pol2qm74 5626 36 invading invade VBG cord-015021-pol2qm74 5626 37 microorganisms microorganism NNS cord-015021-pol2qm74 5626 38 . . . cord-015021-pol2qm74 5627 1 Dept Dept NNP cord-015021-pol2qm74 5627 2 . . NNP cord-015021-pol2qm74 5627 3 of of IN cord-015021-pol2qm74 5627 4 Surgery surgery NN cord-015021-pol2qm74 5627 5 , , , cord-015021-pol2qm74 5627 6 Klinikum Klinikum NNP cord-015021-pol2qm74 5627 7 Grosshadern Grosshadern NNP cord-015021-pol2qm74 5627 8 , , , cord-015021-pol2qm74 5627 9 Ludwig Ludwig NNP cord-015021-pol2qm74 5627 10 - - HYPH cord-015021-pol2qm74 5627 11 Maximilians Maximilians NNP cord-015021-pol2qm74 5627 12 - - HYPH cord-015021-pol2qm74 5627 13 University University NNP cord-015021-pol2qm74 5627 14 , , , cord-015021-pol2qm74 5627 15 Munich Munich NNP cord-015021-pol2qm74 5627 16 , , , cord-015021-pol2qm74 5627 17 Germany Germany NNP cord-015021-pol2qm74 5627 18 . . . cord-015021-pol2qm74 5628 1 * * NFP cord-015021-pol2qm74 5628 2 Dept Dept NNP cord-015021-pol2qm74 5628 3 . . NNP cord-015021-pol2qm74 5628 4 of of IN cord-015021-pol2qm74 5628 5 Surgery Surgery NNP cord-015021-pol2qm74 5628 6 , , , cord-015021-pol2qm74 5628 7 University University NNP cord-015021-pol2qm74 5628 8 of of IN cord-015021-pol2qm74 5628 9 Cincinnati Cincinnati NNP cord-015021-pol2qm74 5628 10 , , , cord-015021-pol2qm74 5628 11 Cincinnati Cincinnati NNP cord-015021-pol2qm74 5628 12 , , , cord-015021-pol2qm74 5628 13 Ohio Ohio NNP cord-015021-pol2qm74 5628 14 , , , cord-015021-pol2qm74 5628 15 USA USA NNP cord-015021-pol2qm74 5628 16 LG LG NNP cord-015021-pol2qm74 5628 17 Thijs~ Thijs~ NNP cord-015021-pol2qm74 5629 1 CE CE NNP cord-015021-pol2qm74 5629 2 N N NNP cord-015021-pol2qm74 5630 1 ~ck ~ck NNP cord-015021-pol2qm74 5630 2 Sepsis sepsis NN cord-015021-pol2qm74 5630 3 is be VBZ cord-015021-pol2qm74 5630 4 the the DT cord-015021-pol2qm74 5630 5 most most RBS cord-015021-pol2qm74 5630 6 common common JJ cord-015021-pol2qm74 5630 7 cause cause NN cord-015021-pol2qm74 5630 8 of of IN cord-015021-pol2qm74 5630 9 acute acute JJ cord-015021-pol2qm74 5630 10 disseminated disseminate VBN cord-015021-pol2qm74 5630 11 intravascular intravascular JJ cord-015021-pol2qm74 5630 12 coagulation coagulation NN cord-015021-pol2qm74 5630 13 ( ( -LRB- cord-015021-pol2qm74 5630 14 DIC DIC NNP cord-015021-pol2qm74 5630 15 ) ) -RRB- cord-015021-pol2qm74 5630 16 and and CC cord-015021-pol2qm74 5630 17 coagulation coagulation NN cord-015021-pol2qm74 5630 18 disorders disorder NNS cord-015021-pol2qm74 5630 19 as as RB cord-015021-pol2qm74 5630 20 well well RB cord-015021-pol2qm74 5630 21 as as IN cord-015021-pol2qm74 5631 1 abnormalities abnormality NNS cord-015021-pol2qm74 5631 2 of of IN cord-015021-pol2qm74 5631 3 fibrinolysis fibrinolysis NN cord-015021-pol2qm74 5631 4 are be VBP cord-015021-pol2qm74 5631 5 common common JJ cord-015021-pol2qm74 5631 6 in in IN cord-015021-pol2qm74 5631 7 septic septic JJ cord-015021-pol2qm74 5631 8 patients patient NNS cord-015021-pol2qm74 5631 9 . . . cord-015021-pol2qm74 5632 1 Some some DT cord-015021-pol2qm74 5632 2 clinical clinical JJ cord-015021-pol2qm74 5632 3 and and CC cord-015021-pol2qm74 5632 4 experimental experimental JJ cord-015021-pol2qm74 5632 5 studies study NNS cord-015021-pol2qm74 5632 6 indicate indicate VBP cord-015021-pol2qm74 5632 7 that that IN cord-015021-pol2qm74 5632 8 DIC DIC NNP cord-015021-pol2qm74 5632 9 is be VBZ cord-015021-pol2qm74 5632 10 a a DT cord-015021-pol2qm74 5632 11 pathogenetic pathogenetic JJ cord-015021-pol2qm74 5632 12 factor factor NN cord-015021-pol2qm74 5632 13 for for IN cord-015021-pol2qm74 5632 14 the the DT cord-015021-pol2qm74 5632 15 development development NN cord-015021-pol2qm74 5632 16 of of IN cord-015021-pol2qm74 5632 17 multiple multiple JJ cord-015021-pol2qm74 5632 18 organ organ NN cord-015021-pol2qm74 5632 19 failure failure NN cord-015021-pol2qm74 5632 20 . . . cord-015021-pol2qm74 5633 1 Endotoxin endotoxin NN cord-015021-pol2qm74 5633 2 and and CC cord-015021-pol2qm74 5633 3 various various JJ cord-015021-pol2qm74 5633 4 mediators mediator NNS cord-015021-pol2qm74 5633 5 ( ( -LRB- cord-015021-pol2qm74 5633 6 TNF TNF NNP cord-015021-pol2qm74 5633 7 , , , cord-015021-pol2qm74 5633 8 IL IL NNP cord-015021-pol2qm74 5633 9 - - : cord-015021-pol2qm74 5633 10 I I NNP cord-015021-pol2qm74 5633 11 ) ) -RRB- cord-015021-pol2qm74 5633 12 enhance enhance VBP cord-015021-pol2qm74 5633 13 tissue tissue NN cord-015021-pol2qm74 5633 14 factor factor NN cord-015021-pol2qm74 5633 15 and and CC cord-015021-pol2qm74 5633 16 decrease decrease VB cord-015021-pol2qm74 5633 17 expression expression NN cord-015021-pol2qm74 5633 18 of of IN cord-015021-pol2qm74 5633 19 thrombomodulin thrombomodulin NNP cord-015021-pol2qm74 5633 20 on on IN cord-015021-pol2qm74 5633 21 endothelial endothelial JJ cord-015021-pol2qm74 5633 22 cells cell NNS cord-015021-pol2qm74 5633 23 in in IN cord-015021-pol2qm74 5633 24 vitro vitro FW cord-015021-pol2qm74 5633 25 . . . cord-015021-pol2qm74 5634 1 Also also RB cord-015021-pol2qm74 5634 2 , , , cord-015021-pol2qm74 5634 3 tPA tpa NN cord-015021-pol2qm74 5634 4 activity activity NN cord-015021-pol2qm74 5634 5 is be VBZ cord-015021-pol2qm74 5634 6 suppressed suppress VBN cord-015021-pol2qm74 5634 7 and and CC cord-015021-pol2qm74 5634 8 release release NN cord-015021-pol2qm74 5634 9 of of IN cord-015021-pol2qm74 5634 10 PAI PAI NNP cord-015021-pol2qm74 5634 11 - - : cord-015021-pol2qm74 5634 12 I -PRON- PRP cord-015021-pol2qm74 5634 13 is be VBZ cord-015021-pol2qm74 5634 14 stimulated stimulate VBN cord-015021-pol2qm74 5634 15 . . . cord-015021-pol2qm74 5635 1 In in IN cord-015021-pol2qm74 5635 2 such such PDT cord-015021-pol2qm74 5635 3 a a DT cord-015021-pol2qm74 5635 4 way way NN cord-015021-pol2qm74 5635 5 the the DT cord-015021-pol2qm74 5635 6 endothelial endothelial JJ cord-015021-pol2qm74 5635 7 surface surface NN cord-015021-pol2qm74 5635 8 becomes become VBZ cord-015021-pol2qm74 5635 9 procoagulant procoagulant NN cord-015021-pol2qm74 5635 10 whereas whereas IN cord-015021-pol2qm74 5635 11 fibrinolysis fibrinolysis NNP cord-015021-pol2qm74 5635 12 is be VBZ cord-015021-pol2qm74 5635 13 inhibited inhibit VBN cord-015021-pol2qm74 5635 14 . . . cord-015021-pol2qm74 5636 1 Following follow VBG cord-015021-pol2qm74 5636 2 administration administration NN cord-015021-pol2qm74 5636 3 of of IN cord-015021-pol2qm74 5636 4 endotoxin endotoxin NN cord-015021-pol2qm74 5636 5 to to IN cord-015021-pol2qm74 5636 6 normal normal JJ cord-015021-pol2qm74 5636 7 volunteers volunteer NNS cord-015021-pol2qm74 5636 8 levels level NNS cord-015021-pol2qm74 5636 9 of of IN cord-015021-pol2qm74 5636 10 prothrombin prothrombin NN cord-015021-pol2qm74 5636 11 fragments fragment NNS cord-015021-pol2qm74 5636 12 ( ( -LRB- cord-015021-pol2qm74 5636 13 FI+2 FI+2 NNP cord-015021-pol2qm74 5636 14 ) ) -RRB- cord-015021-pol2qm74 5636 15 and and CC cord-015021-pol2qm74 5636 16 thrombin thrombin NN cord-015021-pol2qm74 5636 17 - - HYPH cord-015021-pol2qm74 5636 18 antithrombin antithrombin NN cord-015021-pol2qm74 5636 19 ( ( -LRB- cord-015021-pol2qm74 5636 20 TAT tat NN cord-015021-pol2qm74 5636 21 ) ) -RRB- cord-015021-pol2qm74 5636 22 complexes complex NNS cord-015021-pol2qm74 5636 23 increase increase VBP cord-015021-pol2qm74 5636 24 , , , cord-015021-pol2qm74 5636 25 indicating indicate VBG cord-015021-pol2qm74 5636 26 thrombin thrombin JJ cord-015021-pol2qm74 5636 27 generation generation NN cord-015021-pol2qm74 5636 28 . . . cord-015021-pol2qm74 5637 1 Also also RB cord-015021-pol2qm74 5637 2 the the DT cord-015021-pol2qm74 5637 3 fibrinolytic fibrinolytic JJ cord-015021-pol2qm74 5637 4 system system NN cord-015021-pol2qm74 5637 5 is be VBZ cord-015021-pol2qm74 5637 6 activated activate VBN cord-015021-pol2qm74 5637 7 as as IN cord-015021-pol2qm74 5637 8 evidenced evidence VBN cord-015021-pol2qm74 5637 9 by by IN cord-015021-pol2qm74 5637 10 a a DT cord-015021-pol2qm74 5637 11 rise rise NN cord-015021-pol2qm74 5637 12 of of IN cord-015021-pol2qm74 5637 13 levels level NNS cord-015021-pol2qm74 5637 14 of of IN cord-015021-pol2qm74 5637 15 tPA tPA NNP cord-015021-pol2qm74 5637 16 and and CC cord-015021-pol2qm74 5637 17 plasmin plasmin NNP cord-015021-pol2qm74 5637 18 - - HYPH cord-015021-pol2qm74 5637 19 antiplasmin antiplasmin NNP cord-015021-pol2qm74 5637 20 ( ( -LRB- cord-015021-pol2qm74 5637 21 PAP pap NN cord-015021-pol2qm74 5637 22 ) ) -RRB- cord-015021-pol2qm74 5637 23 complexes complex NNS cord-015021-pol2qm74 5638 1 but but CC cord-015021-pol2qm74 5638 2 this this DT cord-015021-pol2qm74 5638 3 is be VBZ cord-015021-pol2qm74 5638 4 counteracted counteract VBN cord-015021-pol2qm74 5638 5 by by IN cord-015021-pol2qm74 5638 6 a a DT cord-015021-pol2qm74 5638 7 subsequent subsequent JJ cord-015021-pol2qm74 5638 8 release release NN cord-015021-pol2qm74 5638 9 of of IN cord-015021-pol2qm74 5638 10 PAI PAI NNP cord-015021-pol2qm74 5638 11 - - HYPH cord-015021-pol2qm74 5638 12 I. I. NNP cord-015021-pol2qm74 5639 1 In in IN cord-015021-pol2qm74 5639 2 severely severely RB cord-015021-pol2qm74 5639 3 ill ill JJ cord-015021-pol2qm74 5639 4 septic septic JJ cord-015021-pol2qm74 5639 5 patients patient NNS cord-015021-pol2qm74 5639 6 levels level NNS cord-015021-pol2qm74 5639 7 of of IN cord-015021-pol2qm74 5639 8 TAT tat NN cord-015021-pol2qm74 5639 9 complexes complex NNS cord-015021-pol2qm74 5639 10 are be VBP cord-015021-pol2qm74 5639 11 increased increase VBN cord-015021-pol2qm74 5639 12 and and CC cord-015021-pol2qm74 5639 13 concentrations concentration NNS cord-015021-pol2qm74 5639 14 of of IN cord-015021-pol2qm74 5639 15 the the DT cord-015021-pol2qm74 5639 16 natural natural JJ cord-015021-pol2qm74 5639 17 inhibitors inhibitor NNS cord-015021-pol2qm74 5639 18 of of IN cord-015021-pol2qm74 5639 19 coagulation coagulation NN cord-015021-pol2qm74 5639 20 ( ( -LRB- cord-015021-pol2qm74 5639 21 AT at IN cord-015021-pol2qm74 5639 22 III III NNP cord-015021-pol2qm74 5639 23 , , , cord-015021-pol2qm74 5639 24 protein protein NN cord-015021-pol2qm74 5639 25 C C NNP cord-015021-pol2qm74 5639 26 ) ) -RRB- cord-015021-pol2qm74 5639 27 are be VBP cord-015021-pol2qm74 5639 28 usually usually RB cord-015021-pol2qm74 5639 29 decreased decrease VBN cord-015021-pol2qm74 5639 30 . . . cord-015021-pol2qm74 5640 1 Also also RB cord-015021-pol2qm74 5640 2 , , , cord-015021-pol2qm74 5640 3 tPA tPA NNP cord-015021-pol2qm74 5640 4 levels level NNS cord-015021-pol2qm74 5640 5 snd snd NNP cord-015021-pol2qm74 5640 6 PAP pap NN cord-015021-pol2qm74 5640 7 complexes complex NNS cord-015021-pol2qm74 5640 8 as as RB cord-015021-pol2qm74 5640 9 well well RB cord-015021-pol2qm74 5640 10 as as IN cord-015021-pol2qm74 5640 11 concentrations concentration NNS cord-015021-pol2qm74 5640 12 of of IN cord-015021-pol2qm74 5640 13 PAI PAI NNP cord-015021-pol2qm74 5640 14 - - : cord-015021-pol2qm74 5640 15 I -PRON- PRP cord-015021-pol2qm74 5640 16 are be VBP cord-015021-pol2qm74 5640 17 elevated elevated JJ cord-015021-pol2qm74 5640 18 . . . cord-015021-pol2qm74 5641 1 The the DT cord-015021-pol2qm74 5641 2 severity severity NN cord-015021-pol2qm74 5641 3 of of IN cord-015021-pol2qm74 5641 4 many many JJ cord-015021-pol2qm74 5641 5 of of IN cord-015021-pol2qm74 5641 6 these these DT cord-015021-pol2qm74 5641 7 alterations alteration NNS cord-015021-pol2qm74 5641 8 is be VBZ cord-015021-pol2qm74 5641 9 related relate VBN cord-015021-pol2qm74 5641 10 to to IN cord-015021-pol2qm74 5641 11 mortality mortality NN cord-015021-pol2qm74 5641 12 . . . cord-015021-pol2qm74 5642 1 Thus thus RB cord-015021-pol2qm74 5642 2 , , , cord-015021-pol2qm74 5642 3 both both DT cord-015021-pol2qm74 5642 4 coagulation coagulation NN cord-015021-pol2qm74 5642 5 and and CC cord-015021-pol2qm74 5642 6 fibrinolysis fibrinolysis NN cord-015021-pol2qm74 5642 7 are be VBP cord-015021-pol2qm74 5642 8 activated activate VBN cord-015021-pol2qm74 5642 9 in in IN cord-015021-pol2qm74 5642 10 sepsis sepsis NN cord-015021-pol2qm74 5642 11 , , , cord-015021-pol2qm74 5642 12 but but CC cord-015021-pol2qm74 5642 13 not not RB cord-015021-pol2qm74 5642 14 in in IN cord-015021-pol2qm74 5642 15 a a DT cord-015021-pol2qm74 5642 16 balanced balanced JJ cord-015021-pol2qm74 5642 17 way way NN cord-015021-pol2qm74 5642 18 , , , cord-015021-pol2qm74 5642 19 thereby thereby RB cord-015021-pol2qm74 5642 20 promoting promote VBG cord-015021-pol2qm74 5642 21 coagulation coagulation NN cord-015021-pol2qm74 5642 22 . . . cord-015021-pol2qm74 5643 1 One one CD cord-015021-pol2qm74 5643 2 of of IN cord-015021-pol2qm74 5643 3 the the DT cord-015021-pol2qm74 5643 4 hallmsxk hallmsxk NNP cord-015021-pol2qm74 5643 5 pathological pathological JJ cord-015021-pol2qm74 5643 6 alterations alteration NNS cord-015021-pol2qm74 5643 7 associated associate VBN cord-015021-pol2qm74 5643 8 with with IN cord-015021-pol2qm74 5643 9 sepsis sepsis NN cord-015021-pol2qm74 5643 10 is be VBZ cord-015021-pol2qm74 5643 11 the the DT cord-015021-pol2qm74 5643 12 development development NN cord-015021-pol2qm74 5643 13 of of IN cord-015021-pol2qm74 5643 14 microvascular microvascular JJ cord-015021-pol2qm74 5643 15 thrombosis thrombosis NN cord-015021-pol2qm74 5643 16 , , , cord-015021-pol2qm74 5643 17 an an DT cord-015021-pol2qm74 5643 18 entity entity NN cord-015021-pol2qm74 5644 1 ~lmre~ ~lmre~ NNP cord-015021-pol2qm74 5645 1 erizod erizod NNP cord-015021-pol2qm74 5645 2 by by IN cord-015021-pol2qm74 5645 3 microvas microvas NNP cord-015021-pol2qm74 5645 4 ~ ~ NFP cord-015021-pol2qm74 5645 5 tlar tlar NNP cord-015021-pol2qm74 5645 6 plugBing plugbe VBG cord-015021-pol2qm74 5645 7 with with IN cord-015021-pol2qm74 5645 8 leukoeyies leukoeyie NNS cord-015021-pol2qm74 5645 9 ( ( -LRB- cord-015021-pol2qm74 5645 10 predominately predominately RB cord-015021-pol2qm74 5645 11 nentrophils nentrophils NNP cord-015021-pol2qm74 5645 12 ) ) -RRB- cord-015021-pol2qm74 5645 13 and and CC cord-015021-pol2qm74 5645 14 fibrin fibrin NN cord-015021-pol2qm74 5645 15 deposits deposit NNS cord-015021-pol2qm74 5645 16 . . . cord-015021-pol2qm74 5646 1 PreRanably preranably RB cord-015021-pol2qm74 5646 2 , , , cord-015021-pol2qm74 5646 3 ischemia ischemia NN cord-015021-pol2qm74 5646 4 remlt~ remlt~ NNP cord-015021-pol2qm74 5647 1 g g NNP cord-015021-pol2qm74 5647 2 fibm fibm NNP cord-015021-pol2qm74 5648 1 ve~-'ttlac ve~-'ttlac NNP cord-015021-pol2qm74 5648 2 ow,.luwion ow,.luwion NN cord-015021-pol2qm74 5648 3 contributes contribute VBZ cord-015021-pol2qm74 5648 4 sisni.ficantly sisni.ficantly RB cord-015021-pol2qm74 5648 5 to to TO cord-015021-pol2qm74 5648 6 end end VB cord-015021-pol2qm74 5648 7 orgen orgen NNP cord-015021-pol2qm74 5648 8 darnaje darnaje NNP cord-015021-pol2qm74 5648 9 and and CC cord-015021-pol2qm74 5648 10 consequent consequent NN cord-015021-pol2qm74 5648 11 dysfatlctlon dysfatlctlon NN cord-015021-pol2qm74 5648 12 . . . cord-015021-pol2qm74 5649 1 P p NN cord-015021-pol2qm74 5649 2 , , , cord-015021-pol2qm74 5649 3 er er UH cord-015021-pol2qm74 5649 4 ~ ~ NN cord-015021-pol2qm74 5649 5 t t NNP cord-015021-pol2qm74 5649 6 sRldies sRldies NNP cord-015021-pol2qm74 5649 7 haw haw NNP cord-015021-pol2qm74 5649 8 focused focus VBD cord-015021-pol2qm74 5649 9 pmdominately pmdominately RB cord-015021-pol2qm74 5649 10 on on IN cord-015021-pol2qm74 5649 11 the the DT cord-015021-pol2qm74 5649 12 role role NN cord-015021-pol2qm74 5649 13 of of IN cord-015021-pol2qm74 5649 14 adhesion adhesion NN cord-015021-pol2qm74 5649 15 molecules molecule NNS cord-015021-pol2qm74 5649 16 in in IN cord-015021-pol2qm74 5649 17 the the DT cord-015021-pol2qm74 5649 18 pathogenesis pathogenesis NN cord-015021-pol2qm74 5649 19 of of IN cord-015021-pol2qm74 5649 20 neu~ neu~ NNP cord-015021-pol2qm74 5650 1 ophil ophil NNP cord-015021-pol2qm74 5650 2 sequestration sequestration NN cord-015021-pol2qm74 5650 3 during during IN cord-015021-pol2qm74 5650 4 infection infection NN cord-015021-pol2qm74 5650 5 and and CC cord-015021-pol2qm74 5650 6 s s NN cord-015021-pol2qm74 5650 7 ~ ~ NFP cord-015021-pol2qm74 5650 8 sis sis NN cord-015021-pol2qm74 5650 9 . . . cord-015021-pol2qm74 5651 1 This this DT cord-015021-pol2qm74 5651 2 preparation preparation NN cord-015021-pol2qm74 5651 3 will will MD cord-015021-pol2qm74 5651 4 review review VB cord-015021-pol2qm74 5651 5 the the DT cord-015021-pol2qm74 5651 6 mechanisms mechanism NNS cord-015021-pol2qm74 5652 1 underlying underlie VBG cord-015021-pol2qm74 5652 2 intravak-'v.ler intravak-'v.ler CD cord-015021-pol2qm74 5653 1 i i PRP cord-015021-pol2qm74 5653 2 ~ ~ CD cord-015021-pol2qm74 5653 3 brin brin NNP cord-015021-pol2qm74 5653 4 deposition deposition NNP cord-015021-pol2qm74 5653 5 and and CC cord-015021-pol2qm74 5653 6 its -PRON- PRP$ cord-015021-pol2qm74 5653 7 contribution contribution NN cord-015021-pol2qm74 5653 8 to to IN cord-015021-pol2qm74 5653 9 organ organ NN cord-015021-pol2qm74 5653 10 injury injury NN cord-015021-pol2qm74 5653 11 . . . cord-015021-pol2qm74 5654 1 The the DT cord-015021-pol2qm74 5654 2 normal normal JJ cord-015021-pol2qm74 5654 3 endothelial endothelial JJ cord-015021-pol2qm74 5654 4 cell cell NN cord-015021-pol2qm74 5654 5 sure sure RB cord-015021-pol2qm74 5654 6 is be VBZ cord-015021-pol2qm74 5654 7 generally generally RB cord-015021-pol2qm74 5654 8 conddered conddered JJ cord-015021-pol2qm74 5654 9 1o 1o CD cord-015021-pol2qm74 5654 10 be be VB cord-015021-pol2qm74 5654 11 anticos anticos NNP cord-015021-pol2qm74 5654 12 ~ ~ NFP cord-015021-pol2qm74 5654 13 am am NN cord-015021-pol2qm74 5654 14 . . . cord-015021-pol2qm74 5655 1 This this DT cord-015021-pol2qm74 5655 2 state state NN cord-015021-pol2qm74 5655 3 is be VBZ cord-015021-pol2qm74 5655 4 maintained maintain VBN cord-015021-pol2qm74 5655 5 by by IN cord-015021-pol2qm74 5655 6 two two CD cord-015021-pol2qm74 5655 7 major major JJ cord-015021-pol2qm74 5655 8 anticoag anticoag NN cord-015021-pol2qm74 5655 9 ~ ~ NFP cord-015021-pol2qm74 5655 10 lam lam NNP cord-015021-pol2qm74 5655 11 molecules molecule NNS cord-015021-pol2qm74 5655 12 on on IN cord-015021-pol2qm74 5655 13 the the DT cord-015021-pol2qm74 5655 14 cell cell NN cord-015021-pol2qm74 5656 1 so so RB cord-015021-pol2qm74 5656 2 , , , cord-015021-pol2qm74 5656 3 ace ace NN cord-015021-pol2qm74 5656 4 : : : cord-015021-pol2qm74 5656 5 hepax'an hepax'an NNP cord-015021-pol2qm74 5656 6 su su NNP cord-015021-pol2qm74 5656 7 , , , cord-015021-pol2qm74 5656 8 lfale lfale NNP cord-015021-pol2qm74 5656 9 and and CC cord-015021-pol2qm74 5656 10 thmmbomodulin thmmbomodulin NNP cord-015021-pol2qm74 5656 11 . . . cord-015021-pol2qm74 5657 1 Studies study NNS cord-015021-pol2qm74 5657 2 performed perform VBN cord-015021-pol2qm74 5657 3 over over IN cord-015021-pol2qm74 5657 4 the the DT cord-015021-pol2qm74 5657 5 past past JJ cord-015021-pol2qm74 5657 6 decade decade NN cord-015021-pol2qm74 5657 7 have have VBP cord-015021-pol2qm74 5657 8 do do VBP cord-015021-pol2qm74 5657 9 ~ ~ CD cord-015021-pol2qm74 5657 10 mentod mentod NNP cord-015021-pol2qm74 5657 11 a a DT cord-015021-pol2qm74 5657 12 general general JJ cord-015021-pol2qm74 5657 13 shii~ shii~ NNP cord-015021-pol2qm74 5657 14 towards towards IN cord-015021-pol2qm74 5657 15 a a DT cord-015021-pol2qm74 5657 16 procoa procoa NNS cord-015021-pol2qm74 5657 17 ~ ~ NFP cord-015021-pol2qm74 5657 18 qtlant qtlant NNP cord-015021-pol2qm74 5657 19 staw staw NNP cord-015021-pol2qm74 5657 20 during during IN cord-015021-pol2qm74 5657 21 gram gram NN cord-015021-pol2qm74 5657 22 negative negative JJ cord-015021-pol2qm74 5657 23 hffeodon hffeodon NN cord-015021-pol2qm74 5657 24 , , , cord-015021-pol2qm74 5657 25 aft aft JJ cord-015021-pol2qm74 5657 26 e~| e~| NNP cord-015021-pol2qm74 5657 27 mediated mediate VBN cord-015021-pol2qm74 5657 28 mainly mainly RB cord-015021-pol2qm74 5657 29 by by IN cord-015021-pol2qm74 5657 30 changes change NNS cord-015021-pol2qm74 5657 31 in in IN cord-015021-pol2qm74 5657 32 the the DT cord-015021-pol2qm74 5657 33 endothalial endothalial JJ cord-015021-pol2qm74 5657 34 cell cell NN cord-015021-pol2qm74 5657 35 surface surface NN cord-015021-pol2qm74 5657 36 . . . cord-015021-pol2qm74 5658 1 antt antt NNP cord-015021-pol2qm74 5658 2 - - HYPH cord-015021-pol2qm74 5658 3 TF TF NNP cord-015021-pol2qm74 5658 4 antibodies antibody NNS cord-015021-pol2qm74 5658 5 have have VBP cord-015021-pol2qm74 5658 6 been be VBN cord-015021-pol2qm74 5658 7 shown show VBN cord-015021-pol2qm74 5658 8 to to TO cord-015021-pol2qm74 5658 9 be be VB cord-015021-pol2qm74 5658 10 pro pro JJ cord-015021-pol2qm74 5658 11 ~ ~ XX cord-015021-pol2qm74 5658 12 ective ective JJ cord-015021-pol2qm74 5658 13 during during IN cord-015021-pol2qm74 5658 14 l~'ml l~'ml NNP cord-015021-pol2qm74 5658 15 endotexemia endotexemia NN cord-015021-pol2qm74 5658 16 . . . cord-015021-pol2qm74 5659 1 In in IN cord-015021-pol2qm74 5659 2 summary summary NN cord-015021-pol2qm74 5659 3 , , , cord-015021-pol2qm74 5659 4 ~erova~'~ler ~erova~'~ler ADD cord-015021-pol2qm74 5659 5 fibrin fibrin NN cord-015021-pol2qm74 5659 6 deposition deposition NN cord-015021-pol2qm74 5659 7 , , , cord-015021-pol2qm74 5659 8 in in IN cord-015021-pol2qm74 5659 9 ~rt ~rt NNP cord-015021-pol2qm74 5659 10 mediated mediate VBN cord-015021-pol2qm74 5659 11 by by IN cord-015021-pol2qm74 5659 12 ~rcgulation ~rcgulation NNP cord-015021-pol2qm74 5659 13 of of IN cord-015021-pol2qm74 5659 14 cellular cellular JJ cord-015021-pol2qm74 5659 15 TF TF NNP cord-015021-pol2qm74 5659 16 , , , cord-015021-pol2qm74 5659 17 is be VBZ cord-015021-pol2qm74 5659 18 a a DT cord-015021-pol2qm74 5659 19 consistemt consistemt NNP cord-015021-pol2qm74 5659 20 patholo patholo NNP cord-015021-pol2qm74 5659 21 ~ ~ NFP cord-015021-pol2qm74 5659 22 cal cal XX cord-015021-pol2qm74 5659 23 flndin~ flndin~ NNP cord-015021-pol2qm74 5659 24 during during IN cord-015021-pol2qm74 5659 25 sepsis sepsis NN cord-015021-pol2qm74 5659 26 and and CC cord-015021-pol2qm74 5659 27 contributes contribute VBZ cord-015021-pol2qm74 5659 28 to to IN cord-015021-pol2qm74 5659 29 organ organ NN cord-015021-pol2qm74 5659 30 injury injury NN cord-015021-pol2qm74 5659 31 . . . cord-015021-pol2qm74 5660 1 Strategies strategy NNS cord-015021-pol2qm74 5660 2 designed design VBN cord-015021-pol2qm74 5660 3 to to TO cord-015021-pol2qm74 5660 4 abrogate abrogate VB cord-015021-pol2qm74 5660 5 this this DT cord-015021-pol2qm74 5660 6 event event NN cord-015021-pol2qm74 5660 7 may may MD cord-015021-pol2qm74 5660 8 n n VB cord-015021-pol2qm74 5660 9 ~ ~ NFP cord-015021-pol2qm74 5660 10 nimJze nimJze NNP cord-015021-pol2qm74 5660 11 the the DT cord-015021-pol2qm74 5660 12 magnitude magnitude NN cord-015021-pol2qm74 5660 13 of of IN cord-015021-pol2qm74 5660 14 erg~ erg~ CD cord-015021-pol2qm74 5660 15 dysftm dysftm NNP cord-015021-pol2qm74 5660 16 ~ ~ NFP cord-015021-pol2qm74 5660 17 on on IN cord-015021-pol2qm74 5660 18 . . . cord-015021-pol2qm74 5661 1 N N NNP cord-015021-pol2qm74 5661 2 , , , cord-015021-pol2qm74 5661 3 V V NNP cord-015021-pol2qm74 5661 4 , , , cord-015021-pol2qm74 5661 5 Christou Christou NNP cord-015021-pol2qm74 5661 6 MD MD NNP cord-015021-pol2qm74 5661 7 PhD phd NN cord-015021-pol2qm74 5661 8 , , , cord-015021-pol2qm74 5661 9 Department Department NNP cord-015021-pol2qm74 5661 10 of of IN cord-015021-pol2qm74 5661 11 Surgery Surgery NNP cord-015021-pol2qm74 5661 12 , , , cord-015021-pol2qm74 5661 13 MeGill MeGill NNP cord-015021-pol2qm74 5661 14 University University NNP cord-015021-pol2qm74 5661 15 , , , cord-015021-pol2qm74 5661 16 Montreal Montreal NNP cord-015021-pol2qm74 5661 17 , , , cord-015021-pol2qm74 5661 18 Quebec Quebec NNP cord-015021-pol2qm74 5661 19 , , , cord-015021-pol2qm74 5661 20 CANADA CANADA NNP cord-015021-pol2qm74 5661 21 Interactions Interactions NNPS cord-015021-pol2qm74 5661 22 between between IN cord-015021-pol2qm74 5661 23 Immune Immune NNP cord-015021-pol2qm74 5661 24 calls call NNS cord-015021-pol2qm74 5661 25 and and CC cord-015021-pol2qm74 5661 26 the the DT cord-015021-pol2qm74 5661 27 endothelium endothelium NN cord-015021-pol2qm74 5661 28 vie vie IN cord-015021-pol2qm74 5661 29 adhesion adhesion NN cord-015021-pol2qm74 5661 30 molecules molecule NNS cord-015021-pol2qm74 5661 31 serve serve VBP cord-015021-pol2qm74 5661 32 to to TO cord-015021-pol2qm74 5661 33 modulate modulate VB cord-015021-pol2qm74 5661 34 immune immune JJ cord-015021-pol2qm74 5661 35 cell cell NN cord-015021-pol2qm74 5661 36 traffic traffic NN cord-015021-pol2qm74 5661 37 between between IN cord-015021-pol2qm74 5661 38 the the DT cord-015021-pol2qm74 5661 39 blood blood NN cord-015021-pol2qm74 5661 40 strum strum NN cord-015021-pol2qm74 5661 41 and and CC cord-015021-pol2qm74 5661 42 the the DT cord-015021-pol2qm74 5661 43 extrmvascular extrmvascular JJ cord-015021-pol2qm74 5661 44 space space NN cord-015021-pol2qm74 5661 45 , , , cord-015021-pol2qm74 5661 46 These these DT cord-015021-pol2qm74 5661 47 families family NNS cord-015021-pol2qm74 5661 48 of of IN cord-015021-pol2qm74 5661 49 molecules molecule NNS cord-015021-pol2qm74 5661 50 acting act VBG cord-015021-pol2qm74 5661 51 in in IN cord-015021-pol2qm74 5661 52 a a DT cord-015021-pol2qm74 5661 53 cascade cascade NN cord-015021-pol2qm74 5661 54 and and CC cord-015021-pol2qm74 5661 55 closely closely RB cord-015021-pol2qm74 5661 56 integrated integrate VBN cord-015021-pol2qm74 5661 57 with with IN cord-015021-pol2qm74 5661 58 the the DT cord-015021-pol2qm74 5661 59 oytoklna oytoklna NNP cord-015021-pol2qm74 5661 60 network network NN cord-015021-pol2qm74 5661 61 , , , cord-015021-pol2qm74 5661 62 blood blood NN cord-015021-pol2qm74 5661 63 coagulation coagulation NN cord-015021-pol2qm74 5661 64 and and CC cord-015021-pol2qm74 5661 65 the the DT cord-015021-pol2qm74 5661 66 complement complement NN cord-015021-pol2qm74 5661 67 system system NN cord-015021-pol2qm74 5661 68 , , , cord-015021-pol2qm74 5661 69 are be VBP cord-015021-pol2qm74 5661 70 responsible responsible JJ cord-015021-pol2qm74 5661 71 for for IN cord-015021-pol2qm74 5661 72 the the DT cord-015021-pol2qm74 5661 73 homing homing NN cord-015021-pol2qm74 5661 74 of of IN cord-015021-pol2qm74 5661 75 leukocytes leukocyte NNS cord-015021-pol2qm74 5661 76 to to IN cord-015021-pol2qm74 5661 77 areas area NNS cord-015021-pol2qm74 5661 78 of of IN cord-015021-pol2qm74 5661 79 inflammation inflammation NN cord-015021-pol2qm74 5661 80 and and CC cord-015021-pol2qm74 5661 81 the the DT cord-015021-pol2qm74 5661 82 realrculatlon realrculatlon NN cord-015021-pol2qm74 5661 83 of of IN cord-015021-pol2qm74 5661 84 tymphocytes tymphocyte NNS cord-015021-pol2qm74 5661 85 . . . cord-015021-pol2qm74 5662 1 There there EX cord-015021-pol2qm74 5662 2 are be VBP cord-015021-pol2qm74 5662 3 three three CD cord-015021-pol2qm74 5662 4 types type NNS cord-015021-pol2qm74 5662 5 of of IN cord-015021-pol2qm74 5662 6 immune immune JJ cord-015021-pol2qm74 5662 7 ceils ceil NNS cord-015021-pol2qm74 5662 8 that that WDT cord-015021-pol2qm74 5662 9 must must MD cord-015021-pol2qm74 5662 10 exit exit VB cord-015021-pol2qm74 5662 11 the the DT cord-015021-pol2qm74 5662 12 blood blood NN cord-015021-pol2qm74 5662 13 stream stream NN cord-015021-pol2qm74 5662 14 into into IN cord-015021-pol2qm74 5662 15 the the DT cord-015021-pol2qm74 5662 16 extravascular extravascular JJ cord-015021-pol2qm74 5662 17 space space NN cord-015021-pol2qm74 5662 18 : : : cord-015021-pol2qm74 5662 19 lymphocytes lymphocyte NNS cord-015021-pol2qm74 5662 20 ; ; : cord-015021-pol2qm74 5662 21 polymorphonuclear polymorphonuclear NNP cord-015021-pol2qm74 5662 22 leukocytes leukocyte NNS cord-015021-pol2qm74 5662 23 ; ; : cord-015021-pol2qm74 5662 24 and and CC cord-015021-pol2qm74 5662 25 non non JJ cord-015021-pol2qm74 5662 26 - - JJ cord-015021-pol2qm74 5662 27 lymphocyta lymphocyta JJ cord-015021-pol2qm74 5662 28 mononuclaar mononuclaar NN cord-015021-pol2qm74 5662 29 cells cell NNS cord-015021-pol2qm74 5662 30 ( ( -LRB- cord-015021-pol2qm74 5662 31 monooytes monooytes NNP cord-015021-pol2qm74 5662 32 , , , cord-015021-pol2qm74 5662 33 basophlls basophlls NNP cord-015021-pol2qm74 5662 34 , , , cord-015021-pol2qm74 5662 35 aoslncphils aoslncphils NNP cord-015021-pol2qm74 5662 36 ) ) -RRB- cord-015021-pol2qm74 5662 37 . . . cord-015021-pol2qm74 5663 1 B b NN cord-015021-pol2qm74 5663 2 lymphocytes lymphocyte NNS cord-015021-pol2qm74 5663 3 exit exit VBP cord-015021-pol2qm74 5663 4 the the DT cord-015021-pol2qm74 5663 5 blood blood NN cord-015021-pol2qm74 5663 6 stream stream NN cord-015021-pol2qm74 5663 7 and and CC cord-015021-pol2qm74 5663 8 recircu}ate recircu}ate VB cord-015021-pol2qm74 5663 9 mostly mostly RB cord-015021-pol2qm74 5663 10 via via IN cord-015021-pol2qm74 5663 11 the the DT cord-015021-pol2qm74 5663 12 high high JJ cord-015021-pol2qm74 5663 13 endothelial endothelial JJ cord-015021-pol2qm74 5663 14 venule venule NN cord-015021-pol2qm74 5663 15 ( ( -LRB- cord-015021-pol2qm74 5663 16 HEV HEV NNP cord-015021-pol2qm74 5663 17 ) ) -RRB- cord-015021-pol2qm74 5663 18 in in IN cord-015021-pol2qm74 5663 19 lymphatic lymphatic JJ cord-015021-pol2qm74 5663 20 tissue tissue NN cord-015021-pol2qm74 5663 21 , , , cord-015021-pol2qm74 5663 22 Rarely rarely RB cord-015021-pol2qm74 5663 23 , , , cord-015021-pol2qm74 5663 24 in in IN cord-015021-pol2qm74 5663 25 chronic chronic JJ cord-015021-pol2qm74 5663 26 } } -RRB- cord-015021-pol2qm74 5663 27 nfectlon= nfectlon= NN cord-015021-pol2qm74 5663 28 , , , cord-015021-pol2qm74 5663 29 they -PRON- PRP cord-015021-pol2qm74 5663 30 may may MD cord-015021-pol2qm74 5663 31 recirQulate recirqulate VB cord-015021-pol2qm74 5664 1 vie vie NNP cord-015021-pol2qm74 5664 2 HEV hev VB cord-015021-pol2qm74 5664 3 in in IN cord-015021-pol2qm74 5664 4 non non JJ cord-015021-pol2qm74 5664 5 - - JJ cord-015021-pol2qm74 5664 6 lymphoi lymphoi JJ cord-015021-pol2qm74 5664 7 : : : cord-015021-pol2qm74 5664 8 t t NN cord-015021-pol2qm74 5664 9 tissue tissue NN cord-015021-pol2qm74 5664 10 . . . cord-015021-pol2qm74 5665 1 T t NN cord-015021-pol2qm74 5665 2 - - HYPH cord-015021-pol2qm74 5665 3 lymphocyte lymphocyte NN cord-015021-pol2qm74 5665 4 recircutation recircutation NN cord-015021-pol2qm74 5665 5 on on IN cord-015021-pol2qm74 5665 6 the the DT cord-015021-pol2qm74 5665 7 other other JJ cord-015021-pol2qm74 5665 8 hand hand NN cord-015021-pol2qm74 5665 9 can can MD cord-015021-pol2qm74 5665 10 occur occur VB cord-015021-pol2qm74 5665 11 via via IN cord-015021-pol2qm74 5665 12 HEV HEV NNP cord-015021-pol2qm74 5665 13 in in IN cord-015021-pol2qm74 5665 14 lymphoid lymphoid JJ cord-015021-pol2qm74 5665 15 tissue tissue NN cord-015021-pol2qm74 5665 16 , , , cord-015021-pol2qm74 5665 17 as as RB cord-015021-pol2qm74 5665 18 well well RB cord-015021-pol2qm74 5665 19 as as IN cord-015021-pol2qm74 5665 20 , , , cord-015021-pol2qm74 5665 21 the the DT cord-015021-pol2qm74 5665 22 endothalium endothalium NN cord-015021-pol2qm74 5665 23 of of IN cord-015021-pol2qm74 5665 24 the the DT cord-015021-pol2qm74 5665 25 skin skin NN cord-015021-pol2qm74 5665 26 , , , cord-015021-pol2qm74 5665 27 returning return VBG cord-015021-pol2qm74 5665 28 to to IN cord-015021-pol2qm74 5665 29 peripheral peripheral JJ cord-015021-pol2qm74 5665 30 lymph lymph NN cord-015021-pol2qm74 5665 31 nodes node NNS cord-015021-pol2qm74 5665 32 via via IN cord-015021-pol2qm74 5665 33 the the DT cord-015021-pol2qm74 5665 34 lymphatic lymphatic JJ cord-015021-pol2qm74 5665 35 channels channel NNS cord-015021-pol2qm74 5665 36 . . . cord-015021-pol2qm74 5666 1 Lymphocyte lymphocyte NN cord-015021-pol2qm74 5666 2 recirculation recirculation NN cord-015021-pol2qm74 5666 3 is be VBZ cord-015021-pol2qm74 5666 4 the the DT cord-015021-pol2qm74 5666 5 mechanism mechanism NN cord-015021-pol2qm74 5666 6 which which WDT cord-015021-pol2qm74 5666 7 allows allow VBZ cord-015021-pol2qm74 5666 8 ¢ontaot ¢ontaot VBN cord-015021-pol2qm74 5666 9 between between IN cord-015021-pol2qm74 5666 10 the the DT cord-015021-pol2qm74 5666 11 immune immune JJ cord-015021-pol2qm74 5666 12 repertoire repertoire NN cord-015021-pol2qm74 5666 13 and and CC cord-015021-pol2qm74 5666 14 pathogens pathogen NNS cord-015021-pol2qm74 5666 15 , , , cord-015021-pol2qm74 5666 16 and and CC cord-015021-pol2qm74 5666 17 homing homing NN cord-015021-pol2qm74 5666 18 delivers deliver VBZ cord-015021-pol2qm74 5666 19 these these DT cord-015021-pol2qm74 5666 20 cells cell NNS cord-015021-pol2qm74 5666 21 to to IN cord-015021-pol2qm74 5666 22 the the DT cord-015021-pol2qm74 5666 23 appropriate appropriate JJ cord-015021-pol2qm74 5666 24 environment environment NN cord-015021-pol2qm74 5666 25 for for IN cord-015021-pol2qm74 5666 26 activation activation NN cord-015021-pol2qm74 5666 27 and and CC cord-015021-pol2qm74 5666 28 for for IN cord-015021-pol2qm74 5666 29 effeotor effeotor NN cord-015021-pol2qm74 5666 30 function function NN cord-015021-pol2qm74 5666 31 , , , cord-015021-pol2qm74 5666 32 PMNs pmn NNS cord-015021-pol2qm74 5666 33 exit exit NN cord-015021-pol2qm74 5666 34 the the DT cord-015021-pol2qm74 5666 35 blood blood NN cord-015021-pol2qm74 5666 36 stream stream NN cord-015021-pol2qm74 5666 37 through through IN cord-015021-pol2qm74 5666 38 endotbelium endotbelium NN cord-015021-pol2qm74 5666 39 in in IN cord-015021-pol2qm74 5666 40 close close JJ cord-015021-pol2qm74 5666 41 proximity proximity NN cord-015021-pol2qm74 5666 42 to to IN cord-015021-pol2qm74 5666 43 the the DT cord-015021-pol2qm74 5666 44 site site NN cord-015021-pol2qm74 5666 45 of of IN cord-015021-pol2qm74 5666 46 inflammation inflammation NN cord-015021-pol2qm74 5666 47 after after IN cord-015021-pol2qm74 5666 48 appropriate appropriate JJ cord-015021-pol2qm74 5666 49 endothelial endothelial JJ cord-015021-pol2qm74 5666 50 membrane membrane NN cord-015021-pol2qm74 5666 51 receptor receptor NN cord-015021-pol2qm74 5666 52 expression expression NN cord-015021-pol2qm74 5666 53 . . . cord-015021-pol2qm74 5667 1 They -PRON- PRP cord-015021-pol2qm74 5667 2 must must MD cord-015021-pol2qm74 5667 3 reach reach VB cord-015021-pol2qm74 5667 4 the the DT cord-015021-pol2qm74 5667 5 site site NN cord-015021-pol2qm74 5667 6 of of IN cord-015021-pol2qm74 5667 7 pathogen pathogen NN cord-015021-pol2qm74 5667 8 tnveslon tnveslon NN cord-015021-pol2qm74 5667 9 quickly quickly RB cord-015021-pol2qm74 5667 10 in in IN cord-015021-pol2qm74 5667 11 order order NN cord-015021-pol2qm74 5667 12 to to TO cord-015021-pol2qm74 5667 13 be be VB cord-015021-pol2qm74 5667 14 effective effective JJ cord-015021-pol2qm74 5667 15 . . . cord-015021-pol2qm74 5668 1 Their -PRON- PRP$ cord-015021-pol2qm74 5668 2 exudation exudation NN cord-015021-pol2qm74 5668 3 to to IN cord-015021-pol2qm74 5668 4 the the DT cord-015021-pol2qm74 5668 5 inflammatory inflammatory JJ cord-015021-pol2qm74 5668 6 site site NN cord-015021-pol2qm74 5668 7 can can MD cord-015021-pol2qm74 5668 8 be be VB cord-015021-pol2qm74 5668 9 modulated modulate VBN cord-015021-pol2qm74 5668 10 by by IN cord-015021-pol2qm74 5668 11 their -PRON- PRP$ cord-015021-pol2qm74 5668 12 intravascular intravascular JJ cord-015021-pol2qm74 5668 13 pdmlng pdmlng NN cord-015021-pol2qm74 5668 14 , , , cord-015021-pol2qm74 5668 15 which which WDT cord-015021-pol2qm74 5668 16 results result VBZ cord-015021-pol2qm74 5668 17 from from IN cord-015021-pol2qm74 5668 18 appropriate appropriate JJ cord-015021-pol2qm74 5668 19 receptor receptor NN cord-015021-pol2qm74 5668 20 expression expression NN cord-015021-pol2qm74 5668 21 . . . cord-015021-pol2qm74 5669 1 Because because IN cord-015021-pol2qm74 5669 2 endotoxin endotoxin NN cord-015021-pol2qm74 5669 3 leak leak NN cord-015021-pol2qm74 5669 4 from from IN cord-015021-pol2qm74 5669 5 the the DT cord-015021-pol2qm74 5669 6 gut gut NN cord-015021-pol2qm74 5669 7 has have VBZ cord-015021-pol2qm74 5669 8 been be VBN cord-015021-pol2qm74 5669 9 postulated postulate VBN cord-015021-pol2qm74 5669 10 as as IN cord-015021-pol2qm74 5669 11 an an DT cord-015021-pol2qm74 5669 12 important important JJ cord-015021-pol2qm74 5669 13 trigger trigger NN cord-015021-pol2qm74 5669 14 mechanism mechanism NN cord-015021-pol2qm74 5669 15 for for IN cord-015021-pol2qm74 5669 16 the the DT cord-015021-pol2qm74 5669 17 systemic systemic JJ cord-015021-pol2qm74 5669 18 inflammatory inflammatory JJ cord-015021-pol2qm74 5669 19 response response NN cord-015021-pol2qm74 5669 20 syndrome syndrome NN cord-015021-pol2qm74 5669 21 seen see VBN cord-015021-pol2qm74 5669 22 after after IN cord-015021-pol2qm74 5669 23 serious serious JJ cord-015021-pol2qm74 5669 24 injury injury NN cord-015021-pol2qm74 5669 25 , , , cord-015021-pol2qm74 5669 26 the the DT cord-015021-pol2qm74 5669 27 immunologic immunologic JJ cord-015021-pol2qm74 5669 28 and and CC cord-015021-pol2qm74 5669 29 metabolic metabolic JJ cord-015021-pol2qm74 5669 30 effects effect NNS cord-015021-pol2qm74 5669 31 of of IN cord-015021-pol2qm74 5669 32 bacterial bacterial JJ cord-015021-pol2qm74 5669 33 endotoxin endotoxin NN cord-015021-pol2qm74 5669 34 infusion infusion NN cord-015021-pol2qm74 5669 35 into into IN cord-015021-pol2qm74 5669 36 normal normal JJ cord-015021-pol2qm74 5669 37 volunteers volunteer NNS cord-015021-pol2qm74 5669 38 can can MD cord-015021-pol2qm74 5669 39 be be VB cord-015021-pol2qm74 5669 40 expected expect VBN cord-015021-pol2qm74 5669 41 to to TO cord-015021-pol2qm74 5669 42 shed shed VB cord-015021-pol2qm74 5669 43 considerable considerable JJ cord-015021-pol2qm74 5669 44 light light NN cord-015021-pol2qm74 5669 45 on on IN cord-015021-pol2qm74 5669 46 the the DT cord-015021-pol2qm74 5669 47 validity validity NN cord-015021-pol2qm74 5669 48 of of IN cord-015021-pol2qm74 5669 49 this this DT cord-015021-pol2qm74 5669 50 hypothesis hypothesis NN cord-015021-pol2qm74 5669 51 . . . cord-015021-pol2qm74 5670 1 We -PRON- PRP cord-015021-pol2qm74 5670 2 and and CC cord-015021-pol2qm74 5670 3 ethers ether NNS cord-015021-pol2qm74 5670 4 have have VBP cord-015021-pol2qm74 5670 5 used use VBN cord-015021-pol2qm74 5670 6 tbis tbis NN cord-015021-pol2qm74 5670 7 model model NN cord-015021-pol2qm74 5670 8 to to TO cord-015021-pol2qm74 5670 9 show show VB cord-015021-pol2qm74 5670 10 that that IN cord-015021-pol2qm74 5670 11 endotoxin endotoxin NN cord-015021-pol2qm74 5670 12 causes cause VBZ cord-015021-pol2qm74 5670 13 a a DT cord-015021-pol2qm74 5670 14 temporary temporary JJ cord-015021-pol2qm74 5670 15 paralysis paralysis NN cord-015021-pol2qm74 5670 16 in in IN cord-015021-pol2qm74 5670 17 the the DT cord-015021-pol2qm74 5670 18 ability ability NN cord-015021-pol2qm74 5670 19 of of IN cord-015021-pol2qm74 5670 20 circulating circulate VBG cord-015021-pol2qm74 5670 21 monocytes monocyte NNS cord-015021-pol2qm74 5670 22 to to TO cord-015021-pol2qm74 5670 23 prudce prudce VB cord-015021-pol2qm74 5670 24 the the DT cord-015021-pol2qm74 5670 25 proinflammatory proinflammatory JJ cord-015021-pol2qm74 5670 26 cytokines cytokine NNS cord-015021-pol2qm74 5671 1 Interleukin Interleukin NNP cord-015021-pol2qm74 5671 2 - - HYPH cord-015021-pol2qm74 5671 3 i i NNP cord-015021-pol2qm74 5671 4 ( ( -LRB- cord-015021-pol2qm74 5671 5 IL IL NNP cord-015021-pol2qm74 5671 6 - - HYPH cord-015021-pol2qm74 5671 7 I I NNP cord-015021-pol2qm74 5671 8 ) ) -RRB- cord-015021-pol2qm74 5671 9 and and CC cord-015021-pol2qm74 5671 10 TNF TNF NNP cord-015021-pol2qm74 5671 11 - - HYPH cord-015021-pol2qm74 5671 12 a a NNP cord-015021-pol2qm74 5671 13 . . . cord-015021-pol2qm74 5672 1 Endotoxin endotoxin NN cord-015021-pol2qm74 5672 2 , , , cord-015021-pol2qm74 5672 3 however however RB cord-015021-pol2qm74 5672 4 , , , cord-015021-pol2qm74 5672 5 causes cause VBZ cord-015021-pol2qm74 5672 6 increased increase VBN cord-015021-pol2qm74 5672 7 production production NN cord-015021-pol2qm74 5672 8 of of IN cord-015021-pol2qm74 5672 9 PGE2 PGE2 NNP cord-015021-pol2qm74 5672 10 by by IN cord-015021-pol2qm74 5672 11 the the DT cord-015021-pol2qm74 5672 12 same same JJ cord-015021-pol2qm74 5672 13 cell cell NN cord-015021-pol2qm74 5672 14 population population NN cord-015021-pol2qm74 5672 15 . . . cord-015021-pol2qm74 5673 1 Endotoxin endotoxin NN cord-015021-pol2qm74 5673 2 infusion infusion NN cord-015021-pol2qm74 5673 3 causes cause VBZ cord-015021-pol2qm74 5673 4 significant significant JJ cord-015021-pol2qm74 5673 5 suppression suppression NN cord-015021-pol2qm74 5673 6 of of IN cord-015021-pol2qm74 5673 7 circulating circulate VBG cord-015021-pol2qm74 5673 8 T t NN cord-015021-pol2qm74 5673 9 - - HYPH cord-015021-pol2qm74 5673 10 cell cell NN cord-015021-pol2qm74 5673 11 numbers number NNS cord-015021-pol2qm74 5673 12 and and CC cord-015021-pol2qm74 5673 13 a a DT cord-015021-pol2qm74 5673 14 profound profound JJ cord-015021-pol2qm74 5673 15 suppression suppression NN cord-015021-pol2qm74 5673 16 in in IN cord-015021-pol2qm74 5673 17 the the DT cord-015021-pol2qm74 5673 18 ability ability NN cord-015021-pol2qm74 5673 19 of of IN cord-015021-pol2qm74 5673 20 the the DT cord-015021-pol2qm74 5673 21 circulating circulate VBG cord-015021-pol2qm74 5673 22 T t NN cord-015021-pol2qm74 5673 23 - - HYPH cord-015021-pol2qm74 5673 24 cell cell NN cord-015021-pol2qm74 5673 25 population population NN cord-015021-pol2qm74 5673 26 to to TO cord-015021-pol2qm74 5673 27 proliferate proliferate VB cord-015021-pol2qm74 5673 28 and and CC cord-015021-pol2qm74 5673 29 to to TO cord-015021-pol2qm74 5673 30 produce produce VB cord-015021-pol2qm74 5673 31 Interle Interle NNP cord-015021-pol2qm74 5674 1 ~in-2 ~in-2 NFP cord-015021-pol2qm74 5674 2 ( ( -LRB- cord-015021-pol2qm74 5674 3 IL-2 IL-2 NNP cord-015021-pol2qm74 5674 4 ) ) -RRB- cord-015021-pol2qm74 5674 5 upon upon IN cord-015021-pol2qm74 5674 6 in in FW cord-015021-pol2qm74 5674 7 vitro vitro FW cord-015021-pol2qm74 5674 8 stimulation stimulation NN cord-015021-pol2qm74 5674 9 . . . cord-015021-pol2qm74 5675 1 After after IN cord-015021-pol2qm74 5675 2 endotoxin endotoxin NN cord-015021-pol2qm74 5675 3 circulating circulate VBG cord-015021-pol2qm74 5675 4 T T NNP cord-015021-pol2qm74 5675 5 - - HYPH cord-015021-pol2qm74 5675 6 cells cell NNS cord-015021-pol2qm74 5675 7 are be VBP cord-015021-pol2qm74 5675 8 also also RB cord-015021-pol2qm74 5675 9 more more RBR cord-015021-pol2qm74 5675 10 sensitive sensitive JJ cord-015021-pol2qm74 5675 11 to to IN cord-015021-pol2qm74 5675 12 the the DT cord-015021-pol2qm74 5675 13 inhibitory inhibitory JJ cord-015021-pol2qm74 5675 14 action action NN cord-015021-pol2qm74 5675 15 of of IN cord-015021-pol2qm74 5675 16 exogenous exogenous JJ cord-015021-pol2qm74 5675 17 PGE2 PGE2 NNP cord-015021-pol2qm74 5675 18 . . . cord-015021-pol2qm74 5676 1 Administration administration NN cord-015021-pol2qm74 5676 2 of of IN cord-015021-pol2qm74 5676 3 cyclooxygenase cyclooxygenase NN cord-015021-pol2qm74 5676 4 inhibitors inhibitor NNS cord-015021-pol2qm74 5676 5 at at IN cord-015021-pol2qm74 5676 6 the the DT cord-015021-pol2qm74 5676 7 time time NN cord-015021-pol2qm74 5676 8 of of IN cord-015021-pol2qm74 5676 9 endotoxin endotoxin NN cord-015021-pol2qm74 5676 10 infusion infusion NN cord-015021-pol2qm74 5676 11 largely largely RB cord-015021-pol2qm74 5676 12 abrogates abrogate VBZ cord-015021-pol2qm74 5676 13 the the DT cord-015021-pol2qm74 5676 14 effect effect NN cord-015021-pol2qm74 5676 15 of of IN cord-015021-pol2qm74 5676 16 endetexin endetexin NN cord-015021-pol2qm74 5676 17 on on IN cord-015021-pol2qm74 5676 18 T T NNP cord-015021-pol2qm74 5676 19 - - HYPH cord-015021-pol2qm74 5676 20 Cell cell NN cord-015021-pol2qm74 5676 21 proliferation proliferation NN cord-015021-pol2qm74 5676 22 and and CC cord-015021-pol2qm74 5676 23 IL-2 il-2 NN cord-015021-pol2qm74 5676 24 production production NN cord-015021-pol2qm74 5676 25 . . . cord-015021-pol2qm74 5677 1 Endotoxin endotoxin NN cord-015021-pol2qm74 5677 2 infusion infusion NN cord-015021-pol2qm74 5677 3 also also RB cord-015021-pol2qm74 5677 4 causes cause VBZ cord-015021-pol2qm74 5677 5 the the DT cord-015021-pol2qm74 5677 6 release release NN cord-015021-pol2qm74 5677 7 of of IN cord-015021-pol2qm74 5677 8 increased increase VBN cord-015021-pol2qm74 5677 9 levels level NNS cord-015021-pol2qm74 5677 10 of of IN cord-015021-pol2qm74 5677 11 circulating circulate VBG cord-015021-pol2qm74 5677 12 catabolic catabolic JJ cord-015021-pol2qm74 5677 13 hormones hormone NNS cord-015021-pol2qm74 5677 14 including include VBG cord-015021-pol2qm74 5677 15 cortisol cortisol NN cord-015021-pol2qm74 5677 16 . . . cord-015021-pol2qm74 5678 1 Administration administration NN cord-015021-pol2qm74 5678 2 of of IN cord-015021-pol2qm74 5678 3 cortisol cortisol NN cord-015021-pol2qm74 5678 4 alone alone RB cord-015021-pol2qm74 5678 5 or or CC cord-015021-pol2qm74 5678 6 cortisol cortisol NN cord-015021-pol2qm74 5678 7 along along RP cord-015021-pol2qm74 5678 8 with with IN cord-015021-pol2qm74 5678 9 endetowin endetowin NNP cord-015021-pol2qm74 5678 10 to to IN cord-015021-pol2qm74 5678 11 volunteers volunteer NNS cord-015021-pol2qm74 5678 12 has have VBZ cord-015021-pol2qm74 5678 13 allowed allow VBN cord-015021-pol2qm74 5678 14 dissection dissection NN cord-015021-pol2qm74 5678 15 of of IN cord-015021-pol2qm74 5678 16 cortisol cortisol NN cord-015021-pol2qm74 5678 17 effects effect NNS cord-015021-pol2qm74 5678 18 from from IN cord-015021-pol2qm74 5678 19 those those DT cord-015021-pol2qm74 5678 20 of of IN cord-015021-pol2qm74 5678 21 endotoxin endotoxin NN cord-015021-pol2qm74 5678 22 itself -PRON- PRP cord-015021-pol2qm74 5678 23 . . . cord-015021-pol2qm74 5679 1 Cortisol cortisol NN cord-015021-pol2qm74 5679 2 infusion infusion NN cord-015021-pol2qm74 5679 3 alone alone RB cord-015021-pol2qm74 5679 4 causes cause VBZ cord-015021-pol2qm74 5679 5 a a DT cord-015021-pol2qm74 5679 6 diminution diminution NN cord-015021-pol2qm74 5679 7 in in IN cord-015021-pol2qm74 5679 8 the the DT cord-015021-pol2qm74 5679 9 circulating circulate VBG cord-015021-pol2qm74 5679 10 T t NN cord-015021-pol2qm74 5679 11 - - HYPH cord-015021-pol2qm74 5679 12 cell cell NN cord-015021-pol2qm74 5679 13 population population NN cord-015021-pol2qm74 5679 14 but but CC cord-015021-pol2qm74 5679 15 the the DT cord-015021-pol2qm74 5679 16 remaining remain VBG cord-015021-pol2qm74 5679 17 ceils ceil NNS cord-015021-pol2qm74 5679 18 continue continue VBP cord-015021-pol2qm74 5679 19 to to TO cord-015021-pol2qm74 5679 20 produce produce VB cord-015021-pol2qm74 5679 21 IL-2 il-2 NN cord-015021-pol2qm74 5680 1 after after IN cord-015021-pol2qm74 5680 2 appropriate appropriate JJ cord-015021-pol2qm74 5680 3 stimulation stimulation NN cord-015021-pol2qm74 5680 4 . . . cord-015021-pol2qm74 5681 1 Cortisol cortisol NN cord-015021-pol2qm74 5681 2 infused infuse VBN cord-015021-pol2qm74 5681 3 along along IN cord-015021-pol2qm74 5681 4 with with IN cord-015021-pol2qm74 5681 5 endotoxin endotoxin NN cord-015021-pol2qm74 5681 6 blocks block VBZ cord-015021-pol2qm74 5681 7 the the DT cord-015021-pol2qm74 5681 8 overshoot overshoot NN cord-015021-pol2qm74 5681 9 in in IN cord-015021-pol2qm74 5681 10 monocyte monocyte NNP cord-015021-pol2qm74 5681 11 proinflammatory proinflammatory JJ cord-015021-pol2qm74 5681 12 cytokine cytokine NN cord-015021-pol2qm74 5681 13 production production NN cord-015021-pol2qm74 5681 14 seen see VBN cord-015021-pol2qm74 5681 15 24 24 CD cord-015021-pol2qm74 5681 16 -48 -48 NNP cord-015021-pol2qm74 5681 17 hours hour NNS cord-015021-pol2qm74 5681 18 after after IN cord-015021-pol2qm74 5681 19 endetoxin endetoxin NN cord-015021-pol2qm74 5681 20 infusion infusion NN cord-015021-pol2qm74 5681 21 . . . cord-015021-pol2qm74 5682 1 At at IN cord-015021-pol2qm74 5682 2 present present NN cord-015021-pol2qm74 5682 3 , , , cord-015021-pol2qm74 5682 4 one one PRP cord-015021-pol2qm74 5682 5 may may MD cord-015021-pol2qm74 5682 6 conclude conclude VB cord-015021-pol2qm74 5682 7 that that IN cord-015021-pol2qm74 5682 8 administration administration NN cord-015021-pol2qm74 5682 9 of of IN cord-015021-pol2qm74 5682 10 sublethal sublethal JJ cord-015021-pol2qm74 5682 11 doses dose NNS cord-015021-pol2qm74 5682 12 of of IN cord-015021-pol2qm74 5682 13 bacterial bacterial JJ cord-015021-pol2qm74 5682 14 endetoxin endetoxin NN cord-015021-pol2qm74 5682 15 to to IN cord-015021-pol2qm74 5682 16 human human JJ cord-015021-pol2qm74 5682 17 volusteers volusteer NNS cord-015021-pol2qm74 5682 18 produces produce VBZ cord-015021-pol2qm74 5682 19 alterations alteration NNS cord-015021-pol2qm74 5682 20 in in IN cord-015021-pol2qm74 5682 21 cytokime cytokime NN cord-015021-pol2qm74 5682 22 production production NN cord-015021-pol2qm74 5682 23 and and CC cord-015021-pol2qm74 5682 24 Tlymphocyte Tlymphocyte NNP cord-015021-pol2qm74 5682 25 activation activation NN cord-015021-pol2qm74 5682 26 which which WDT cord-015021-pol2qm74 5682 27 are be VBP cord-015021-pol2qm74 5682 28 both both DT cord-015021-pol2qm74 5682 29 similar similar JJ cord-015021-pol2qm74 5682 30 and and CC cord-015021-pol2qm74 5682 31 dissimilar dissimilar JJ cord-015021-pol2qm74 5682 32 to to IN cord-015021-pol2qm74 5682 33 those those DT cord-015021-pol2qm74 5682 34 seen see VBN cord-015021-pol2qm74 5682 35 following follow VBG cord-015021-pol2qm74 5682 36 serious serious JJ cord-015021-pol2qm74 5682 37 injury injury NN cord-015021-pol2qm74 5682 38 . . . cord-015021-pol2qm74 5683 1 Hemodynamic Hemodynamic NNP cord-015021-pol2qm74 5683 2 support support NN cord-015021-pol2qm74 5683 3 is be VBZ cord-015021-pol2qm74 5683 4 based base VBN cord-015021-pol2qm74 5683 5 first first RB cord-015021-pol2qm74 5683 6 on on IN cord-015021-pol2qm74 5683 7 intravenous intravenous JJ cord-015021-pol2qm74 5683 8 fluids fluid NNS cord-015021-pol2qm74 5683 9 and and CC cord-015021-pol2qm74 5683 10 second second RB cord-015021-pol2qm74 5683 11 on on IN cord-015021-pol2qm74 5683 12 vasoactive vasoactive JJ cord-015021-pol2qm74 5683 13 agents agent NNS cord-015021-pol2qm74 5683 14 . . . cord-015021-pol2qm74 5684 1 Colloids colloid NNS cord-015021-pol2qm74 5684 2 are be VBP cord-015021-pol2qm74 5684 3 usually usually RB cord-015021-pol2qm74 5684 4 preferred prefer VBN cord-015021-pol2qm74 5684 5 to to IN cord-015021-pol2qm74 5684 6 crystalloids crystalloids NNP cord-015021-pol2qm74 5684 7 , , , cord-015021-pol2qm74 5684 8 for for IN cord-015021-pol2qm74 5684 9 their -PRON- PRP$ cord-015021-pol2qm74 5684 10 more more RBR cord-015021-pol2qm74 5684 11 rapid rapid JJ cord-015021-pol2qm74 5684 12 hemodynamic hemodynamic JJ cord-015021-pol2qm74 5684 13 effects effect NNS cord-015021-pol2qm74 5684 14 and and CC cord-015021-pol2qm74 5684 15 their -PRON- PRP$ cord-015021-pol2qm74 5684 16 lesser less JJR cord-015021-pol2qm74 5684 17 passage passage NN cord-015021-pol2qm74 5684 18 in in IN cord-015021-pol2qm74 5684 19 the the DT cord-015021-pol2qm74 5684 20 interstitial interstitial JJ cord-015021-pol2qm74 5684 21 space space NN cord-015021-pol2qm74 5684 22 . . . cord-015021-pol2qm74 5685 1 In in IN cord-015021-pol2qm74 5685 2 the the DT cord-015021-pol2qm74 5685 3 presence presence NN cord-015021-pol2qm74 5685 4 of of IN cord-015021-pol2qm74 5685 5 hypotension hypotension NN cord-015021-pol2qm74 5685 6 , , , cord-015021-pol2qm74 5685 7 the the DT cord-015021-pol2qm74 5685 8 pharmacological pharmacological JJ cord-015021-pol2qm74 5685 9 profile profile NN cord-015021-pol2qm74 5685 10 of of IN cord-015021-pol2qm74 5685 11 dopamine dopamine NN cord-015021-pol2qm74 5685 12 makes make VBZ cord-015021-pol2qm74 5685 13 it -PRON- PRP cord-015021-pol2qm74 5685 14 the the DT cord-015021-pol2qm74 5685 15 first first JJ cord-015021-pol2qm74 5685 16 agent agent NN cord-015021-pol2qm74 5685 17 of of IN cord-015021-pol2qm74 5685 18 choice choice NN cord-015021-pol2qm74 5685 19 . . . cord-015021-pol2qm74 5686 1 It -PRON- PRP cord-015021-pol2qm74 5686 2 is be VBZ cord-015021-pol2qm74 5686 3 only only RB cord-015021-pol2qm74 5686 4 when when WRB cord-015021-pol2qm74 5686 5 high high JJ cord-015021-pol2qm74 5686 6 doses dose NNS cord-015021-pol2qm74 5686 7 of of IN cord-015021-pol2qm74 5686 8 dopamine dopamine NN cord-015021-pol2qm74 5686 9 are be VBP cord-015021-pol2qm74 5686 10 insufficient insufficient JJ cord-015021-pol2qm74 5686 11 to to TO cord-015021-pol2qm74 5686 12 restore restore VB cord-015021-pol2qm74 5686 13 a a DT cord-015021-pol2qm74 5686 14 sufficient sufficient JJ cord-015021-pol2qm74 5686 15 tissue tissue NN cord-015021-pol2qm74 5686 16 perfusion perfusion NN cord-015021-pol2qm74 5686 17 pressure pressure NN cord-015021-pol2qm74 5686 18 that that IN cord-015021-pol2qm74 5686 19 norepinephrine norepinephrine NN cord-015021-pol2qm74 5686 20 should should MD cord-015021-pol2qm74 5686 21 be be VB cord-015021-pol2qm74 5686 22 added add VBN cord-015021-pol2qm74 5686 23 . . . cord-015021-pol2qm74 5687 1 Even even RB cord-015021-pol2qm74 5687 2 when when WRB cord-015021-pol2qm74 5687 3 cardiac cardiac JJ cord-015021-pol2qm74 5687 4 output output NN cord-015021-pol2qm74 5687 5 is be VBZ cord-015021-pol2qm74 5687 6 not not RB cord-015021-pol2qm74 5687 7 decreased decrease VBN cord-015021-pol2qm74 5687 8 , , , cord-015021-pol2qm74 5687 9 a a DT cord-015021-pol2qm74 5687 10 dobutamine dobutamine JJ cord-015021-pol2qm74 5687 11 infusion infusion NN cord-015021-pol2qm74 5687 12 is be VBZ cord-015021-pol2qm74 5687 13 often often RB cord-015021-pol2qm74 5687 14 indicated indicate VBN cord-015021-pol2qm74 5687 15 to to TO cord-015021-pol2qm74 5687 16 counteract counteract VB cord-015021-pol2qm74 5687 17 the the DT cord-015021-pol2qm74 5687 18 myocardial myocardial JJ cord-015021-pol2qm74 5687 19 depression depression NN cord-015021-pol2qm74 5687 20 , , , cord-015021-pol2qm74 5687 21 prevent prevent VB cord-015021-pol2qm74 5687 22 vasoconstriction vasoconstriction NN cord-015021-pol2qm74 5687 23 , , , cord-015021-pol2qm74 5687 24 and and CC cord-015021-pol2qm74 5687 25 increase increase VB cord-015021-pol2qm74 5687 26 oxygen oxygen NN cord-015021-pol2qm74 5687 27 delivery delivery NN cord-015021-pol2qm74 5687 28 to to IN cord-015021-pol2qm74 5687 29 the the DT cord-015021-pol2qm74 5687 30 tissues tissue NNS cord-015021-pol2qm74 5687 31 . . . cord-015021-pol2qm74 5688 1 The the DT cord-015021-pol2qm74 5688 2 benefit benefit NN cord-015021-pol2qm74 5688 3 derived derive VBN cord-015021-pol2qm74 5688 4 from from IN cord-015021-pol2qm74 5688 5 the the DT cord-015021-pol2qm74 5688 6 administration administration NN cord-015021-pol2qm74 5688 7 of of IN cord-015021-pol2qm74 5688 8 " " `` cord-015021-pol2qm74 5688 9 renal renal JJ cord-015021-pol2qm74 5688 10 " " '' cord-015021-pol2qm74 5688 11 doses dose NNS cord-015021-pol2qm74 5688 12 of of IN cord-015021-pol2qm74 5688 13 dopamine dopamine NN cord-015021-pol2qm74 5688 14 is be VBZ cord-015021-pol2qm74 5688 15 doubtful doubtful JJ cord-015021-pol2qm74 5688 16 , , , cord-015021-pol2qm74 5688 17 but but CC cord-015021-pol2qm74 5688 18 stimulation stimulation NN cord-015021-pol2qm74 5688 19 of of IN cord-015021-pol2qm74 5688 20 dopaminergic dopaminergic JJ cord-015021-pol2qm74 5688 21 receptors receptor NNS cord-015021-pol2qm74 5688 22 may may MD cord-015021-pol2qm74 5688 23 increase increase VB cord-015021-pol2qm74 5688 24 blood blood NN cord-015021-pol2qm74 5688 25 flow flow NN cord-015021-pol2qm74 5688 26 also also RB cord-015021-pol2qm74 5688 27 to to IN cord-015021-pol2qm74 5688 28 the the DT cord-015021-pol2qm74 5688 29 gut gut NN cord-015021-pol2qm74 5688 30 . . . cord-015021-pol2qm74 5689 1 In in IN cord-015021-pol2qm74 5689 2 any any DT cord-015021-pol2qm74 5689 3 case case NN cord-015021-pol2qm74 5689 4 , , , cord-015021-pol2qm74 5689 5 none none NN cord-015021-pol2qm74 5689 6 of of IN cord-015021-pol2qm74 5689 7 these these DT cord-015021-pol2qm74 5689 8 catecholamines catecholamine NNS cord-015021-pol2qm74 5689 9 has have VBZ cord-015021-pol2qm74 5689 10 been be VBN cord-015021-pol2qm74 5689 11 shown show VBN cord-015021-pol2qm74 5689 12 to to TO cord-015021-pol2qm74 5689 13 significantly significantly RB cord-015021-pol2qm74 5689 14 improve improve VB cord-015021-pol2qm74 5689 15 the the DT cord-015021-pol2qm74 5689 16 oxygen oxygen NN cord-015021-pol2qm74 5689 17 extraction extraction NN cord-015021-pol2qm74 5689 18 capabilities capability NNS cord-015021-pol2qm74 5689 19 of of IN cord-015021-pol2qm74 5689 20 the the DT cord-015021-pol2qm74 5689 21 tissues tissue NNS cord-015021-pol2qm74 5689 22 . . . cord-015021-pol2qm74 5690 1 Agents agent NNS cord-015021-pol2qm74 5690 2 with with IN cord-015021-pol2qm74 5690 3 antiinflammatory antiinflammatory JJ cord-015021-pol2qm74 5690 4 properties property NNS cord-015021-pol2qm74 5690 5 but but CC cord-015021-pol2qm74 5690 6 also also RB cord-015021-pol2qm74 5690 7 with with IN cord-015021-pol2qm74 5690 8 some some DT cord-015021-pol2qm74 5690 9 vasodilating vasodilating NN cord-015021-pol2qm74 5690 10 properties property NNS cord-015021-pol2qm74 5690 11 , , , cord-015021-pol2qm74 5690 12 such such JJ cord-015021-pol2qm74 5690 13 as as IN cord-015021-pol2qm74 5690 14 N n CD cord-015021-pol2qm74 5690 15 - - HYPH cord-015021-pol2qm74 5690 16 acetylcysteine acetylcysteine NN cord-015021-pol2qm74 5690 17 , , , cord-015021-pol2qm74 5690 18 prostaglandin prostaglandin NN cord-015021-pol2qm74 5690 19 El El NNP cord-015021-pol2qm74 5690 20 or or CC cord-015021-pol2qm74 5690 21 pentoxifylline pentoxifylline NNP cord-015021-pol2qm74 5690 22 represent represent VBP cord-015021-pol2qm74 5690 23 more more RBR cord-015021-pol2qm74 5690 24 attractive attractive JJ cord-015021-pol2qm74 5690 25 options option NNS cord-015021-pol2qm74 5690 26 to to TO cord-015021-pol2qm74 5690 27 increase increase VB cord-015021-pol2qm74 5690 28 oxygen oxygen NN cord-015021-pol2qm74 5690 29 extraction extraction NN cord-015021-pol2qm74 5690 30 . . . cord-015021-pol2qm74 5691 1 Cardiovascular cardiovascular JJ cord-015021-pol2qm74 5691 2 support support NN cord-015021-pol2qm74 5691 3 should should MD cord-015021-pol2qm74 5691 4 aim aim VB cord-015021-pol2qm74 5691 5 not not RB cord-015021-pol2qm74 5691 6 only only RB cord-015021-pol2qm74 5691 7 at at IN cord-015021-pol2qm74 5691 8 the the DT cord-015021-pol2qm74 5691 9 restoration restoration NN cord-015021-pol2qm74 5691 10 of of IN cord-015021-pol2qm74 5691 11 a a DT cord-015021-pol2qm74 5691 12 sufficient sufficient JJ cord-015021-pol2qm74 5691 13 arterial arterial JJ cord-015021-pol2qm74 5691 14 pressure pressure NN cord-015021-pol2qm74 5691 15 but but CC cord-015021-pol2qm74 5691 16 also also RB cord-015021-pol2qm74 5691 17 at at IN cord-015021-pol2qm74 5691 18 the the DT cord-015021-pol2qm74 5691 19 maintenance maintenance NN cord-015021-pol2qm74 5691 20 of of IN cord-015021-pol2qm74 5691 21 an an DT cord-015021-pol2qm74 5691 22 optimal optimal JJ cord-015021-pol2qm74 5691 23 oxygen oxygen NN cord-015021-pol2qm74 5691 24 delivery delivery NN cord-015021-pol2qm74 5691 25 to to IN cord-015021-pol2qm74 5691 26 the the DT cord-015021-pol2qm74 5691 27 cells cell NNS cord-015021-pol2qm74 5691 28 . . . cord-015021-pol2qm74 5692 1 It -PRON- PRP cord-015021-pol2qm74 5692 2 should should MD cord-015021-pol2qm74 5692 3 thus thus RB cord-015021-pol2qm74 5692 4 be be VB cord-015021-pol2qm74 5692 5 guided guide VBN cord-015021-pol2qm74 5692 6 also also RB cord-015021-pol2qm74 5692 7 by by IN cord-015021-pol2qm74 5692 8 measurements measurement NNS cord-015021-pol2qm74 5692 9 of of IN cord-015021-pol2qm74 5692 10 cardiac cardiac JJ cord-015021-pol2qm74 5692 11 output output NN cord-015021-pol2qm74 5692 12 , , , cord-015021-pol2qm74 5692 13 mixed mixed JJ cord-015021-pol2qm74 5692 14 venous venous JJ cord-015021-pol2qm74 5692 15 oxygen oxygen NN cord-015021-pol2qm74 5692 16 saturation saturation NN cord-015021-pol2qm74 5692 17 and and CC cord-015021-pol2qm74 5692 18 oxygen oxygen NN cord-015021-pol2qm74 5692 19 extraction extraction NN cord-015021-pol2qm74 5692 20 , , , cord-015021-pol2qm74 5692 21 and and CC cord-015021-pol2qm74 5692 22 indexes index NNS cord-015021-pol2qm74 5692 23 of of IN cord-015021-pol2qm74 5692 24 cellular cellular JJ cord-015021-pol2qm74 5692 25 hypoxia hypoxia NN cord-015021-pol2qm74 5692 26 , , , cord-015021-pol2qm74 5692 27 such such JJ cord-015021-pol2qm74 5692 28 as as IN cord-015021-pol2qm74 5692 29 blood blood NN cord-015021-pol2qm74 5692 30 lactate lactate NN cord-015021-pol2qm74 5692 31 levels level NNS cord-015021-pol2qm74 5692 32 , , , cord-015021-pol2qm74 5692 33 gastric gastric JJ cord-015021-pol2qm74 5692 34 intramucosal intramucosal NN cord-015021-pol2qm74 5692 35 pH ph NN cord-015021-pol2qm74 5692 36 or or CC cord-015021-pol2qm74 5692 37 vanearterial vanearterial JJ cord-015021-pol2qm74 5692 38 PC02 PC02 NNP cord-015021-pol2qm74 5692 39 gradients gradient NNS cord-015021-pol2qm74 5692 40 . . . cord-015021-pol2qm74 5692 41 _SP cord-015021-pol2qm74 5693 1 Supranorma Supranorma NNP cord-015021-pol2qm74 5693 2 [ [ -LRB- cord-015021-pol2qm74 5693 3 02 02 CD cord-015021-pol2qm74 5693 4 delivery delivery NN cord-015021-pol2qm74 5693 5 contributes contribute VBZ cord-015021-pol2qm74 5693 6 to to IN cord-015021-pol2qm74 5693 7 the the DT cord-015021-pol2qm74 5693 8 prevention prevention NN cord-015021-pol2qm74 5693 9 of of IN cord-015021-pol2qm74 5693 10 tissue tissue NN cord-015021-pol2qm74 5693 11 hypoxia hypoxia NN cord-015021-pol2qm74 5693 12 Tissue tissue NN cord-015021-pol2qm74 5693 13 hypoxia hypoxia NN cord-015021-pol2qm74 5693 14 is be VBZ cord-015021-pol2qm74 5693 15 considered consider VBN cord-015021-pol2qm74 5693 16 to to TO cord-015021-pol2qm74 5693 17 be be VB cord-015021-pol2qm74 5693 18 the the DT cord-015021-pol2qm74 5693 19 common common JJ cord-015021-pol2qm74 5693 20 final final JJ cord-015021-pol2qm74 5693 21 pathway pathway NN cord-015021-pol2qm74 5693 22 in in IN cord-015021-pol2qm74 5693 23 the the DT cord-015021-pol2qm74 5693 24 pathogenesis pathogenesis NN cord-015021-pol2qm74 5693 25 of of IN cord-015021-pol2qm74 5693 26 multipte multipte NNP cord-015021-pol2qm74 5693 27 systems system NNS cord-015021-pol2qm74 5693 28 organ organ NN cord-015021-pol2qm74 5693 29 failure failure NN cord-015021-pol2qm74 5693 30 . . . cord-015021-pol2qm74 5694 1 It -PRON- PRP cord-015021-pol2qm74 5694 2 may may MD cord-015021-pol2qm74 5694 3 directly directly RB cord-015021-pol2qm74 5694 4 contribute contribute VB cord-015021-pol2qm74 5694 5 to to IN cord-015021-pol2qm74 5694 6 cellular cellular JJ cord-015021-pol2qm74 5694 7 injury injury NN cord-015021-pol2qm74 5694 8 and and CC cord-015021-pol2qm74 5694 9 organ organ NN cord-015021-pol2qm74 5694 10 dysfunction dysfunction NN cord-015021-pol2qm74 5694 11 as as RB cord-015021-pol2qm74 5694 12 well well RB cord-015021-pol2qm74 5694 13 as as IN cord-015021-pol2qm74 5694 14 enhance enhance VB cord-015021-pol2qm74 5694 15 further further JJ cord-015021-pol2qm74 5694 16 mediator mediator NN cord-015021-pol2qm74 5694 17 activation activation NN cord-015021-pol2qm74 5694 18 and and CC cord-015021-pol2qm74 5694 19 release release NN cord-015021-pol2qm74 5694 20 by by IN cord-015021-pol2qm74 5694 21 a a DT cord-015021-pol2qm74 5694 22 positive positive JJ cord-015021-pol2qm74 5694 23 feed feed NN cord-015021-pol2qm74 5694 24 back back NN cord-015021-pol2qm74 5694 25 mechanism mechanism NN cord-015021-pol2qm74 5694 26 . . . cord-015021-pol2qm74 5695 1 Prevention prevention NN cord-015021-pol2qm74 5695 2 of of IN cord-015021-pol2qm74 5695 3 tissue tissue NN cord-015021-pol2qm74 5695 4 hypoxia hypoxia NN cord-015021-pol2qm74 5695 5 , , , cord-015021-pol2qm74 5695 6 is be VBZ cord-015021-pol2qm74 5695 7 therefore therefore RB cord-015021-pol2qm74 5695 8 , , , cord-015021-pol2qm74 5695 9 one one CD cord-015021-pol2qm74 5695 10 of of IN cord-015021-pol2qm74 5695 11 the the DT cord-015021-pol2qm74 5695 12 most most RBS cord-015021-pol2qm74 5695 13 important important JJ cord-015021-pol2qm74 5695 14 aims aim NNS cord-015021-pol2qm74 5695 15 in in IN cord-015021-pol2qm74 5695 16 the the DT cord-015021-pol2qm74 5695 17 supportive supportive JJ cord-015021-pol2qm74 5695 18 therapy therapy NN cord-015021-pol2qm74 5695 19 of of IN cord-015021-pol2qm74 5695 20 critically critically RB cord-015021-pol2qm74 5695 21 ill ill JJ cord-015021-pol2qm74 5695 22 patients patient NNS cord-015021-pol2qm74 5695 23 , , , cord-015021-pol2qm74 5695 24 especially especially RB cord-015021-pol2qm74 5695 25 in in IN cord-015021-pol2qm74 5695 26 those those DT cord-015021-pol2qm74 5695 27 with with IN cord-015021-pol2qm74 5695 28 sepsis sepsis NN cord-015021-pol2qm74 5695 29 and and CC cord-015021-pol2qm74 5695 30 septic septic JJ cord-015021-pol2qm74 5695 31 shock shock NN cord-015021-pol2qm74 5695 32 . . . cord-015021-pol2qm74 5696 1 Mismatch mismatch NN cord-015021-pol2qm74 5696 2 of of IN cord-015021-pol2qm74 5696 3 cellular cellular JJ cord-015021-pol2qm74 5696 4 O= O= NNP cord-015021-pol2qm74 5696 5 supply supply NN cord-015021-pol2qm74 5696 6 and and CC cord-015021-pol2qm74 5696 7 demand demand NN cord-015021-pol2qm74 5696 8 in in IN cord-015021-pol2qm74 5696 9 these these DT cord-015021-pol2qm74 5696 10 patients patient NNS cord-015021-pol2qm74 5696 11 may may MD cord-015021-pol2qm74 5696 12 resuit resuit VB cord-015021-pol2qm74 5696 13 from from IN cord-015021-pol2qm74 5696 14 the the DT cord-015021-pol2qm74 5696 15 impairment impairment NN cord-015021-pol2qm74 5696 16 of of IN cord-015021-pol2qm74 5696 17 the the DT cord-015021-pol2qm74 5696 18 cardiocircu[atory cardiocircu[atory NN cord-015021-pol2qm74 5696 19 system system NN cord-015021-pol2qm74 5696 20 on on IN cord-015021-pol2qm74 5696 21 all all DT cord-015021-pol2qm74 5696 22 levels level NNS cord-015021-pol2qm74 5696 23 . . . cord-015021-pol2qm74 5697 1 1 1 LS cord-015021-pol2qm74 5697 2 . . . cord-015021-pol2qm74 5698 1 Myocardial myocardial JJ cord-015021-pol2qm74 5698 2 depression depression NN cord-015021-pol2qm74 5698 3 with with IN cord-015021-pol2qm74 5698 4 a a DT cord-015021-pol2qm74 5698 5 drop drop NN cord-015021-pol2qm74 5698 6 in in IN cord-015021-pol2qm74 5698 7 02 02 CD cord-015021-pol2qm74 5698 8 delivery delivery NN cord-015021-pol2qm74 5698 9 ( ( -LRB- cord-015021-pol2qm74 5698 10 DO~ DO~ NNP cord-015021-pol2qm74 5698 11 ) ) -RRB- cord-015021-pol2qm74 5698 12 2 2 CD cord-015021-pol2qm74 5698 13 . . . cord-015021-pol2qm74 5699 1 Redistribution redistribution NN cord-015021-pol2qm74 5699 2 of of IN cord-015021-pol2qm74 5699 3 blood blood NN cord-015021-pol2qm74 5699 4 flow flow NN cord-015021-pol2qm74 5699 5 between between IN cord-015021-pol2qm74 5699 6 the the DT cord-015021-pol2qm74 5699 7 different different JJ cord-015021-pol2qm74 5699 8 organ organ NN cord-015021-pol2qm74 5699 9 systems system NNS cord-015021-pol2qm74 5699 10 3 3 CD cord-015021-pol2qm74 5699 11 . . . cord-015021-pol2qm74 5700 1 inadequate inadequate JJ cord-015021-pol2qm74 5700 2 nutritive nutritive JJ cord-015021-pol2qm74 5700 3 blood blood NN cord-015021-pol2qm74 5700 4 flow flow NN cord-015021-pol2qm74 5700 5 due due IN cord-015021-pol2qm74 5700 6 to to IN cord-015021-pol2qm74 5700 7 tissue tissue NN cord-015021-pol2qm74 5700 8 edema edema NN cord-015021-pol2qm74 5700 9 and and CC cord-015021-pol2qm74 5700 10 endothelial endothelial JJ cord-015021-pol2qm74 5700 11 damage damage NN cord-015021-pol2qm74 5701 1 ( ( -LRB- cord-015021-pol2qm74 5701 2 gIC gIC NNP cord-015021-pol2qm74 5701 3 , , , cord-015021-pol2qm74 5701 4 leucocyte leucocyte NNP cord-015021-pol2qm74 5701 5 swelling swell VBG cord-015021-pol2qm74 5701 6 etc etc NN cord-015021-pol2qm74 5701 7 . . . cord-015021-pol2qm74 5701 8 ) ) -RRB- cord-015021-pol2qm74 5702 1 These these DT cord-015021-pol2qm74 5702 2 pathological pathological JJ cord-015021-pol2qm74 5702 3 changes change NNS cord-015021-pol2qm74 5702 4 may may MD cord-015021-pol2qm74 5702 5 go go VB cord-015021-pol2qm74 5702 6 along along RB cord-015021-pol2qm74 5702 7 with with IN cord-015021-pol2qm74 5702 8 increased increase VBN cord-015021-pol2qm74 5702 9 metabolic metabolic JJ cord-015021-pol2qm74 5702 10 needs need NNS cord-015021-pol2qm74 5702 11 . . . cord-015021-pol2qm74 5703 1 Cellular cellular JJ cord-015021-pol2qm74 5703 2 and and CC cord-015021-pol2qm74 5703 3 organ organ NN cord-015021-pol2qm74 5703 4 02 02 CD cord-015021-pol2qm74 5703 5 supply supply NN cord-015021-pol2qm74 5703 6 may may MD cord-015021-pol2qm74 5703 7 therefore therefore RB cord-015021-pol2qm74 5703 8 be be VB cord-015021-pol2qm74 5703 9 inadequately inadequately RB cord-015021-pol2qm74 5703 10 matched match VBN cord-015021-pol2qm74 5703 11 with with IN cord-015021-pol2qm74 5703 12 cellular cellular JJ cord-015021-pol2qm74 5703 13 02 02 CD cord-015021-pol2qm74 5703 14 needs need NNS cord-015021-pol2qm74 5703 15 in in IN cord-015021-pol2qm74 5703 16 patients patient NNS cord-015021-pol2qm74 5703 17 with with IN cord-015021-pol2qm74 5703 18 normal normal JJ cord-015021-pol2qm74 5703 19 and and CC cord-015021-pol2qm74 5703 20 even even RB cord-015021-pol2qm74 5703 21 supral supral JJ cord-015021-pol2qm74 5703 22 normal normal JJ cord-015021-pol2qm74 5703 23 DOz DOz NNS cord-015021-pol2qm74 5703 24 . . . cord-015021-pol2qm74 5704 1 Hyperdynamic Hyperdynamic NNP cord-015021-pol2qm74 5704 2 circulation circulation NN cord-015021-pol2qm74 5704 3 is be VBZ cord-015021-pol2qm74 5704 4 often often RB cord-015021-pol2qm74 5704 5 present present JJ cord-015021-pol2qm74 5704 6 in in IN cord-015021-pol2qm74 5704 7 adequately adequately RB cord-015021-pol2qm74 5704 8 volume volume NN cord-015021-pol2qm74 5704 9 resusucitated resusucitate VBN cord-015021-pol2qm74 5704 10 patients patient NNS cord-015021-pol2qm74 5704 11 . . . cord-015021-pol2qm74 5705 1 It -PRON- PRP cord-015021-pol2qm74 5705 2 is be VBZ cord-015021-pol2qm74 5705 3 most most RBS cord-015021-pol2qm74 5705 4 likely likely JJ cord-015021-pol2qm74 5705 5 that that IN cord-015021-pol2qm74 5705 6 one one CD cord-015021-pol2qm74 5705 7 of of IN cord-015021-pol2qm74 5705 8 the the DT cord-015021-pol2qm74 5705 9 bodys bodys JJ cord-015021-pol2qm74 5705 10 main main JJ cord-015021-pol2qm74 5705 11 compensatory compensatory JJ cord-015021-pol2qm74 5705 12 mechanisms mechanism NNS cord-015021-pol2qm74 5705 13 would would MD cord-015021-pol2qm74 5705 14 maintain maintain VB cord-015021-pol2qm74 5705 15 cellular cellular JJ cord-015021-pol2qm74 5705 16 O= O= NNP cord-015021-pol2qm74 5705 17 supply supply NN cord-015021-pol2qm74 5705 18 in in IN cord-015021-pol2qm74 5705 19 the the DT cord-015021-pol2qm74 5705 20 face face NN cord-015021-pol2qm74 5705 21 of of IN cord-015021-pol2qm74 5705 22 increased increase VBN cord-015021-pol2qm74 5705 23 metabolic metabolic JJ cord-015021-pol2qm74 5705 24 needs need NNS cord-015021-pol2qm74 5705 25 and and CC cord-015021-pol2qm74 5705 26 impaired impair VBN cord-015021-pol2qm74 5705 27 Oz Oz NNP cord-015021-pol2qm74 5705 28 extraction extraction NN cord-015021-pol2qm74 5705 29 capabillities capabillitie NNS cord-015021-pol2qm74 5705 30 . . . cord-015021-pol2qm74 5706 1 This this DT cord-015021-pol2qm74 5706 2 pathophysiology pathophysiology NN cord-015021-pol2qm74 5706 3 may may MD cord-015021-pol2qm74 5706 4 explain explain VB cord-015021-pol2qm74 5706 5 the the DT cord-015021-pol2qm74 5706 6 findings finding NNS cord-015021-pol2qm74 5706 7 in in IN cord-015021-pol2qm74 5706 8 several several JJ cord-015021-pol2qm74 5706 9 clinical clinical JJ cord-015021-pol2qm74 5706 10 investigations investigation NNS cord-015021-pol2qm74 5706 11 that that WDT cord-015021-pol2qm74 5706 12 patients patient NNS cord-015021-pol2qm74 5706 13 with with IN cord-015021-pol2qm74 5706 14 normal normal JJ cord-015021-pol2qm74 5706 15 or or CC cord-015021-pol2qm74 5706 16 even even RB cord-015021-pol2qm74 5706 17 supranormal supranormal JJ cord-015021-pol2qm74 5706 18 DOz DOz NNS cord-015021-pol2qm74 5706 19 can can MD cord-015021-pol2qm74 5706 20 have have VB cord-015021-pol2qm74 5706 21 signs sign NNS cord-015021-pol2qm74 5706 22 of of IN cord-015021-pol2qm74 5706 23 inadequate inadequate JJ cord-015021-pol2qm74 5706 24 regional regional JJ cord-015021-pol2qm74 5706 25 tissue tissue NN cord-015021-pol2qm74 5706 26 oxygenation oxygenation NN cord-015021-pol2qm74 5706 27 . . . cord-015021-pol2qm74 5707 1 It -PRON- PRP cord-015021-pol2qm74 5707 2 is be VBZ cord-015021-pol2qm74 5707 3 also also RB cord-015021-pol2qm74 5707 4 consistent consistent JJ cord-015021-pol2qm74 5707 5 with with IN cord-015021-pol2qm74 5707 6 the the DT cord-015021-pol2qm74 5707 7 results result NNS cord-015021-pol2qm74 5707 8 of of IN cord-015021-pol2qm74 5707 9 different different JJ cord-015021-pol2qm74 5707 10 studies study NNS cord-015021-pol2qm74 5707 11 which which WDT cord-015021-pol2qm74 5707 12 demonstrated demonstrate VBD cord-015021-pol2qm74 5707 13 that that IN cord-015021-pol2qm74 5707 14 the the DT cord-015021-pol2qm74 5707 15 achievement achievement NN cord-015021-pol2qm74 5707 16 of of IN cord-015021-pol2qm74 5707 17 supranormal supranormal JJ cord-015021-pol2qm74 5707 18 DOz DOz NNS cord-015021-pol2qm74 5707 19 levels level NNS cord-015021-pol2qm74 5707 20 , , , cord-015021-pol2qm74 5707 21 either either CC cord-015021-pol2qm74 5707 22 spontanuously spontanuously RB cord-015021-pol2qm74 5707 23 or or CC cord-015021-pol2qm74 5707 24 due due JJ cord-015021-pol2qm74 5707 25 to to TO cord-015021-pol2qm74 5707 26 adequate adequate JJ cord-015021-pol2qm74 5707 27 supportive supportive JJ cord-015021-pol2qm74 5707 28 therapy therapy NN cord-015021-pol2qm74 5707 29 , , , cord-015021-pol2qm74 5707 30 resuits resuit NNS cord-015021-pol2qm74 5707 31 in in IN cord-015021-pol2qm74 5707 32 better well JJR cord-015021-pol2qm74 5707 33 patient patient JJ cord-015021-pol2qm74 5707 34 outcome outcome NN cord-015021-pol2qm74 5707 35 . . . cord-015021-pol2qm74 5708 1 Any any DT cord-015021-pol2qm74 5708 2 attempt attempt NN cord-015021-pol2qm74 5708 3 to to TO cord-015021-pol2qm74 5708 4 prevent prevent VB cord-015021-pol2qm74 5708 5 or or CC cord-015021-pol2qm74 5708 6 treat treat VB cord-015021-pol2qm74 5708 7 tissue tissue NN cord-015021-pol2qm74 5708 8 hypoxia hypoxia NN cord-015021-pol2qm74 5708 9 in in IN cord-015021-pol2qm74 5708 10 these these DT cord-015021-pol2qm74 5708 11 patients patient NNS cord-015021-pol2qm74 5708 12 , , , cord-015021-pol2qm74 5708 13 however however RB cord-015021-pol2qm74 5708 14 , , , cord-015021-pol2qm74 5708 15 has have VBZ cord-015021-pol2qm74 5708 16 to to TO cord-015021-pol2qm74 5708 17 take take VB cord-015021-pol2qm74 5708 18 into into IN cord-015021-pol2qm74 5708 19 account account NN cord-015021-pol2qm74 5708 20 the the DT cord-015021-pol2qm74 5708 21 effects effect NNS cord-015021-pol2qm74 5708 22 of of IN cord-015021-pol2qm74 5708 23 therapy therapy NN cord-015021-pol2qm74 5708 24 not not RB cord-015021-pol2qm74 5708 25 only only RB cord-015021-pol2qm74 5708 26 on on IN cord-015021-pol2qm74 5708 27 global global JJ cord-015021-pol2qm74 5708 28 Dgz Dgz NNP cord-015021-pol2qm74 5708 29 but but CC cord-015021-pol2qm74 5708 30 especially especially RB cord-015021-pol2qm74 5708 31 on on IN cord-015021-pol2qm74 5708 32 regional regional JJ cord-015021-pol2qm74 5708 33 and and CC cord-015021-pol2qm74 5708 34 microcirculatory microcirculatory JJ cord-015021-pol2qm74 5708 35 blood blood NN cord-015021-pol2qm74 5708 36 flow flow NN cord-015021-pol2qm74 5708 37 . . . cord-015021-pol2qm74 5709 1 R. R. NNP cord-015021-pol2qm74 5709 2 Rossaint Rossaint NNP cord-015021-pol2qm74 5709 3 , , , cord-015021-pol2qm74 5709 4 D. D. NNP cord-015021-pol2qm74 5709 5 Pappert Pappert NNP cord-015021-pol2qm74 5709 6 , , , cord-015021-pol2qm74 5709 7 K. K. NNP cord-015021-pol2qm74 5709 8 Lewandowski Lewandowski NNP cord-015021-pol2qm74 5709 9 , , , cord-015021-pol2qm74 5709 10 H. H. NNP cord-015021-pol2qm74 5709 11 Gedach Gedach NNP cord-015021-pol2qm74 5709 12 , , , cord-015021-pol2qm74 5709 13 K. K. NNP cord-015021-pol2qm74 5709 14 Slama Slama NNP cord-015021-pol2qm74 5709 15 , , , cord-015021-pol2qm74 5709 16 K.J. K.J. NNP cord-015021-pol2qm74 5709 17 Falke Falke NNP cord-015021-pol2qm74 5709 18 Klinik Klinik NNP cord-015021-pol2qm74 5709 19 for for IN cord-015021-pol2qm74 5709 20 Anaesthesiologie Anaesthesiologie NNP cord-015021-pol2qm74 5710 1 und und NNP cord-015021-pol2qm74 5711 1 operative operative JJ cord-015021-pol2qm74 5711 2 Intensivmedizin Intensivmedizin NNP cord-015021-pol2qm74 5711 3 , , , cord-015021-pol2qm74 5711 4 UKRV UKRV NNP cord-015021-pol2qm74 5711 5 , , , cord-015021-pol2qm74 5711 6 Freie Freie NNP cord-015021-pol2qm74 5711 7 Universit Universit NNP cord-015021-pol2qm74 5712 1 § § NN cord-015021-pol2qm74 5712 2 t t NNP cord-015021-pol2qm74 5712 3 Berlin Berlin NNP cord-015021-pol2qm74 5712 4 , , , cord-015021-pol2qm74 5712 5 Germany Germany NNP cord-015021-pol2qm74 5712 6 Important important JJ cord-015021-pol2qm74 5712 7 contributory contributory JJ cord-015021-pol2qm74 5712 8 factors factor NNS cord-015021-pol2qm74 5712 9 to to IN cord-015021-pol2qm74 5712 10 the the DT cord-015021-pol2qm74 5712 11 high high JJ cord-015021-pol2qm74 5712 12 mortality mortality NN cord-015021-pol2qm74 5712 13 of of IN cord-015021-pol2qm74 5712 14 severe severe JJ cord-015021-pol2qm74 5712 15 acute acute JJ cord-015021-pol2qm74 5712 16 respiratory respiratory JJ cord-015021-pol2qm74 5712 17 distress distress NN cord-015021-pol2qm74 5712 18 syndrome syndrome NN cord-015021-pol2qm74 5712 19 lARDS lARDS NNP cord-015021-pol2qm74 5712 20 ) ) -RRB- cord-015021-pol2qm74 5712 21 are be VBP cord-015021-pol2qm74 5712 22 the the DT cord-015021-pol2qm74 5712 23 aggressive aggressive JJ cord-015021-pol2qm74 5712 24 therapies therapy NNS cord-015021-pol2qm74 5712 25 required require VBN cord-015021-pol2qm74 5712 26 , , , cord-015021-pol2qm74 5712 27 such such JJ cord-015021-pol2qm74 5712 28 as as IN cord-015021-pol2qm74 5712 29 mechanical mechanical JJ cord-015021-pol2qm74 5712 30 ventilation ventilation NN cord-015021-pol2qm74 5712 31 with with IN cord-015021-pol2qm74 5712 32 high high JJ cord-015021-pol2qm74 5712 33 inspiratory inspiratory JJ cord-015021-pol2qm74 5712 34 oxygen oxygen NN cord-015021-pol2qm74 5712 35 concentrations concentration NNS cord-015021-pol2qm74 5712 36 and and CC cord-015021-pol2qm74 5712 37 airway airway NN cord-015021-pol2qm74 5712 38 pressures pressure NNS cord-015021-pol2qm74 5712 39 . . . cord-015021-pol2qm74 5713 1 As as IN cord-015021-pol2qm74 5713 2 specific specific JJ cord-015021-pol2qm74 5713 3 therapies therapy NNS cord-015021-pol2qm74 5713 4 for for IN cord-015021-pol2qm74 5713 5 reducing reduce VBG cord-015021-pol2qm74 5713 6 or or CC cord-015021-pol2qm74 5713 7 preventing prevent VBG cord-015021-pol2qm74 5713 8 the the DT cord-015021-pol2qm74 5713 9 general general JJ cord-015021-pol2qm74 5713 10 inflammatory inflammatory JJ cord-015021-pol2qm74 5713 11 reaction reaction NN cord-015021-pol2qm74 5713 12 of of IN cord-015021-pol2qm74 5713 13 the the DT cord-015021-pol2qm74 5713 14 lung lung NN cord-015021-pol2qm74 5713 15 resulting result VBG cord-015021-pol2qm74 5713 16 in in IN cord-015021-pol2qm74 5713 17 severe severe JJ cord-015021-pol2qm74 5713 18 hypoxemia hypoxemia NN cord-015021-pol2qm74 5713 19 is be VBZ cord-015021-pol2qm74 5713 20 unknown unknown JJ cord-015021-pol2qm74 5713 21 , , , cord-015021-pol2qm74 5713 22 today today NN cord-015021-pol2qm74 5713 23 's 's POS cord-015021-pol2qm74 5713 24 therapy therapy NN cord-015021-pol2qm74 5713 25 is be VBZ cord-015021-pol2qm74 5713 26 limited limit VBN cord-015021-pol2qm74 5713 27 to to IN cord-015021-pol2qm74 5713 28 procedures procedure NNS cord-015021-pol2qm74 5713 29 which which WDT cord-015021-pol2qm74 5713 30 predominantly predominantly RB cord-015021-pol2qm74 5713 31 support support VBP cord-015021-pol2qm74 5713 32 or or CC cord-015021-pol2qm74 5713 33 maintain maintain VB cord-015021-pol2qm74 5713 34 pulmonary pulmonary JJ cord-015021-pol2qm74 5713 35 function function NN cord-015021-pol2qm74 5713 36 , , , cord-015021-pol2qm74 5713 37 i.e. i.e. FW cord-015021-pol2qm74 5713 38 pressure pressure NN cord-015021-pol2qm74 5713 39 limited limit VBN cord-015021-pol2qm74 5713 40 ventilation ventilation NN cord-015021-pol2qm74 5713 41 with with IN cord-015021-pol2qm74 5713 42 PEEP peep NN cord-015021-pol2qm74 5713 43 and and CC cord-015021-pol2qm74 5713 44 permissive permissive JJ cord-015021-pol2qm74 5713 45 hypercapnea hypercapnea NN cord-015021-pol2qm74 5713 46 , , , cord-015021-pol2qm74 5713 47 avoiding avoid VBG cord-015021-pol2qm74 5713 48 or or CC cord-015021-pol2qm74 5713 49 treatment treatment NN cord-015021-pol2qm74 5713 50 of of IN cord-015021-pol2qm74 5713 51 fluid fluid JJ cord-015021-pol2qm74 5713 52 overloading overloading NN cord-015021-pol2qm74 5713 53 , , , cord-015021-pol2qm74 5713 54 and and CC cord-015021-pol2qm74 5713 55 positional positional JJ cord-015021-pol2qm74 5713 56 maneuvers maneuver NNS cord-015021-pol2qm74 5713 57 . . . cord-015021-pol2qm74 5714 1 Extracorporeal extracorporeal JJ cord-015021-pol2qm74 5714 2 lung lung NN cord-015021-pol2qm74 5714 3 assist assist NN cord-015021-pol2qm74 5714 4 combined combine VBN cord-015021-pol2qm74 5714 5 with with IN cord-015021-pol2qm74 5714 6 low low JJ cord-015021-pol2qm74 5714 7 frequency frequency NN cord-015021-pol2qm74 5714 8 positive positive JJ cord-015021-pol2qm74 5714 9 pressure pressure NN cord-015021-pol2qm74 5714 10 ventilation ventilation NN cord-015021-pol2qm74 5714 11 has have VBZ cord-015021-pol2qm74 5714 12 been be VBN cord-015021-pol2qm74 5714 13 recommended recommend VBN cord-015021-pol2qm74 5714 14 , , , cord-015021-pol2qm74 5714 15 when when WRB cord-015021-pol2qm74 5714 16 conventional conventional JJ cord-015021-pol2qm74 5714 17 therapy therapy NN cord-015021-pol2qm74 5714 18 fails fail VBZ cord-015021-pol2qm74 5714 19 . . . cord-015021-pol2qm74 5715 1 Today today NN cord-015021-pol2qm74 5715 2 , , , cord-015021-pol2qm74 5715 3 extracorporeal extracorporeal JJ cord-015021-pol2qm74 5715 4 gas gas NN cord-015021-pol2qm74 5715 5 exchange exchange NN cord-015021-pol2qm74 5715 6 may may MD cord-015021-pol2qm74 5715 7 be be VB cord-015021-pol2qm74 5715 8 carried carry VBN cord-015021-pol2qm74 5715 9 out out RP cord-015021-pol2qm74 5715 10 using use VBG cord-015021-pol2qm74 5715 11 a a DT cord-015021-pol2qm74 5715 12 system system NN cord-015021-pol2qm74 5715 13 internally internally RB cord-015021-pol2qm74 5715 14 coated coat VBD cord-015021-pol2qm74 5715 15 with with IN cord-015021-pol2qm74 5715 16 covalently covalently RB cord-015021-pol2qm74 5715 17 bound bind VBN cord-015021-pol2qm74 5715 18 heparin heparin NN cord-015021-pol2qm74 5715 19 . . . cord-015021-pol2qm74 5716 1 This this DT cord-015021-pol2qm74 5716 2 allows allow VBZ cord-015021-pol2qm74 5716 3 for for IN cord-015021-pol2qm74 5716 4 a a DT cord-015021-pol2qm74 5716 5 lower low JJR cord-015021-pol2qm74 5716 6 level level NN cord-015021-pol2qm74 5716 7 of of IN cord-015021-pol2qm74 5716 8 systemic systemic JJ cord-015021-pol2qm74 5716 9 heparinzation heparinzation NN cord-015021-pol2qm74 5716 10 reducing reduce VBG cord-015021-pol2qm74 5716 11 the the DT cord-015021-pol2qm74 5716 12 risk risk NN cord-015021-pol2qm74 5716 13 of of IN cord-015021-pol2qm74 5716 14 severe severe JJ cord-015021-pol2qm74 5716 15 hemorrhagic hemorrhagic JJ cord-015021-pol2qm74 5716 16 complications complication NNS cord-015021-pol2qm74 5716 17 of of IN cord-015021-pol2qm74 5716 18 extracorporeal extracorporeal JJ cord-015021-pol2qm74 5716 19 respiratory respiratory JJ cord-015021-pol2qm74 5716 20 support support NN cord-015021-pol2qm74 5716 21 . . . cord-015021-pol2qm74 5717 1 From from IN cord-015021-pol2qm74 5717 2 April April NNP cord-015021-pol2qm74 5717 3 1989 1989 CD cord-015021-pol2qm74 5717 4 to to IN cord-015021-pol2qm74 5717 5 August August NNP cord-015021-pol2qm74 5717 6 1993 1993 CD cord-015021-pol2qm74 5717 7 89 89 CD cord-015021-pol2qm74 5717 8 patients patient NNS cord-015021-pol2qm74 5717 9 , , , cord-015021-pol2qm74 5717 10 aged age VBN cord-015021-pol2qm74 5717 11 from from IN cord-015021-pol2qm74 5717 12 15 15 CD cord-015021-pol2qm74 5717 13 months month NNS cord-015021-pol2qm74 5717 14 to to IN cord-015021-pol2qm74 5717 15 60 60 CD cord-015021-pol2qm74 5717 16 years year NNS cord-015021-pol2qm74 5717 17 , , , cord-015021-pol2qm74 5717 18 were be VBD cord-015021-pol2qm74 5717 19 transferred transfer VBN cord-015021-pol2qm74 5717 20 to to IN cord-015021-pol2qm74 5717 21 our -PRON- PRP$ cord-015021-pol2qm74 5717 22 intensive intensive JJ cord-015021-pol2qm74 5717 23 care care NN cord-015021-pol2qm74 5717 24 unit unit NN cord-015021-pol2qm74 5717 25 ( ( -LRB- cord-015021-pol2qm74 5717 26 ICU ICU NNP cord-015021-pol2qm74 5717 27 ) ) -RRB- cord-015021-pol2qm74 5717 28 for for IN cord-015021-pol2qm74 5717 29 treatment treatment NN cord-015021-pol2qm74 5717 30 of of IN cord-015021-pol2qm74 5717 31 severe severe JJ cord-015021-pol2qm74 5717 32 ARDS ARDS NNP cord-015021-pol2qm74 5717 33 . . . cord-015021-pol2qm74 5718 1 All all DT cord-015021-pol2qm74 5718 2 fulfilled fulfil VBD cord-015021-pol2qm74 5718 3 at at IN cord-015021-pol2qm74 5718 4 least least JJS cord-015021-pol2qm74 5718 5 the the DT cord-015021-pol2qm74 5718 6 slow slow JJ cord-015021-pol2qm74 5718 7 entry entry NN cord-015021-pol2qm74 5718 8 criteria criterion NNS cord-015021-pol2qm74 5718 9 of of IN cord-015021-pol2qm74 5718 10 the the DT cord-015021-pol2qm74 5718 11 U.S. U.S. NNP cord-015021-pol2qm74 5718 12 National National NNP cord-015021-pol2qm74 5718 13 ECMO ECMO NNP cord-015021-pol2qm74 5718 14 Study Study NNP cord-015021-pol2qm74 5718 15 . . . cord-015021-pol2qm74 5719 1 Due due IN cord-015021-pol2qm74 5719 2 to to IN cord-015021-pol2qm74 5719 3 hypoxemia hypoxemia NN cord-015021-pol2qm74 5719 4 13 13 CD cord-015021-pol2qm74 5719 5 patients patient NNS cord-015021-pol2qm74 5719 6 required require VBD cord-015021-pol2qm74 5719 7 veno veno NNP cord-015021-pol2qm74 5719 8 - - HYPH cord-015021-pol2qm74 5719 9 venous venous JJ cord-015021-pol2qm74 5719 10 extracorporeal extracorporeal JJ cord-015021-pol2qm74 5719 11 membrane membrane NN cord-015021-pol2qm74 5719 12 oxygenation oxygenation NN cord-015021-pol2qm74 5719 13 ( ( -LRB- cord-015021-pol2qm74 5719 14 ECMO ECMO NNP cord-015021-pol2qm74 5719 15 ) ) -RRB- cord-015021-pol2qm74 5719 16 immediately immediately RB cord-015021-pol2qm74 5719 17 after after IN cord-015021-pol2qm74 5719 18 transfer transfer NN cord-015021-pol2qm74 5719 19 to to IN cord-015021-pol2qm74 5719 20 our -PRON- PRP$ cord-015021-pol2qm74 5719 21 ICU ICU NNP cord-015021-pol2qm74 5719 22 . . . cord-015021-pol2qm74 5720 1 The the DT cord-015021-pol2qm74 5720 2 other other JJ cord-015021-pol2qm74 5720 3 76 76 CD cord-015021-pol2qm74 5720 4 patients patient NNS cord-015021-pol2qm74 5720 5 were be VBD cord-015021-pol2qm74 5720 6 first first RB cord-015021-pol2qm74 5720 7 treated treat VBN cord-015021-pol2qm74 5720 8 with with IN cord-015021-pol2qm74 5720 9 pressure pressure NN cord-015021-pol2qm74 5720 10 controlled control VBN cord-015021-pol2qm74 5720 11 mechanical mechanical JJ cord-015021-pol2qm74 5720 12 ventilation ventilation NN cord-015021-pol2qm74 5720 13 , , , cord-015021-pol2qm74 5720 14 permissive permissive JJ cord-015021-pol2qm74 5720 15 hypercapnea hypercapnea NN cord-015021-pol2qm74 5720 16 , , , cord-015021-pol2qm74 5720 17 prone prone JJ cord-015021-pol2qm74 5720 18 position position NN cord-015021-pol2qm74 5720 19 , , , cord-015021-pol2qm74 5720 20 and and CC cord-015021-pol2qm74 5720 21 dehydration dehydration NN cord-015021-pol2qm74 5720 22 , , , cord-015021-pol2qm74 5720 23 if if IN cord-015021-pol2qm74 5720 24 necessary necessary JJ cord-015021-pol2qm74 5720 25 . . . cord-015021-pol2qm74 5721 1 In in IN cord-015021-pol2qm74 5721 2 23 23 CD cord-015021-pol2qm74 5721 3 out out IN cord-015021-pol2qm74 5721 4 of of IN cord-015021-pol2qm74 5721 5 these these DT cord-015021-pol2qm74 5721 6 76 76 CD cord-015021-pol2qm74 5721 7 patients patient NNS cord-015021-pol2qm74 5721 8 , , , cord-015021-pol2qm74 5721 9 in in IN cord-015021-pol2qm74 5721 10 which which WDT cord-015021-pol2qm74 5721 11 the the DT cord-015021-pol2qm74 5721 12 gas gas NN cord-015021-pol2qm74 5721 13 exchange exchange NN cord-015021-pol2qm74 5721 14 did do VBD cord-015021-pol2qm74 5721 15 not not RB cord-015021-pol2qm74 5721 16 improve improve VB cord-015021-pol2qm74 5721 17 in in IN cord-015021-pol2qm74 5721 18 the the DT cord-015021-pol2qm74 5721 19 following follow VBG cord-015021-pol2qm74 5721 20 days day NNS cord-015021-pol2qm74 5721 21 , , , cord-015021-pol2qm74 5721 22 veno veno NN cord-015021-pol2qm74 5721 23 - - HYPH cord-015021-pol2qm74 5721 24 venous venous JJ cord-015021-pol2qm74 5721 25 ECMO ECMO NNP cord-015021-pol2qm74 5721 26 with with IN cord-015021-pol2qm74 5721 27 heparin heparin NN cord-015021-pol2qm74 5721 28 - - HYPH cord-015021-pol2qm74 5721 29 coated coat VBN cord-015021-pol2qm74 5721 30 systems system NNS cord-015021-pol2qm74 5721 31 was be VBD cord-015021-pol2qm74 5721 32 additionally additionally RB cord-015021-pol2qm74 5721 33 performed perform VBN cord-015021-pol2qm74 5721 34 . . . cord-015021-pol2qm74 5722 1 Heparin Heparin NNP cord-015021-pol2qm74 5722 2 was be VBD cord-015021-pol2qm74 5722 3 given give VBN cord-015021-pol2qm74 5722 4 to to TO cord-015021-pol2qm74 5722 5 achieve achieve VB cord-015021-pol2qm74 5722 6 a a DT cord-015021-pol2qm74 5722 7 partial partial JJ cord-015021-pol2qm74 5722 8 thrombin thrombin JJ cord-015021-pol2qm74 5722 9 time time NN cord-015021-pol2qm74 5722 10 between between IN cord-015021-pol2qm74 5722 11 40 40 CD cord-015021-pol2qm74 5722 12 -55 -55 NNP cord-015021-pol2qm74 5722 13 s s NNP cord-015021-pol2qm74 5722 14 and and CC cord-015021-pol2qm74 5722 15 an an DT cord-015021-pol2qm74 5722 16 activated activate VBN cord-015021-pol2qm74 5722 17 clotting clotting NN cord-015021-pol2qm74 5722 18 time time NN cord-015021-pol2qm74 5722 19 between between IN cord-015021-pol2qm74 5722 20 120 120 CD cord-015021-pol2qm74 5723 1 -150 -150 NNP cord-015021-pol2qm74 5724 1 s. s. NNP cord-015021-pol2qm74 5725 1 If if IN cord-015021-pol2qm74 5725 2 surgery surgery NN cord-015021-pol2qm74 5725 3 was be VBD cord-015021-pol2qm74 5725 4 performed perform VBN cord-015021-pol2qm74 5725 5 during during IN cord-015021-pol2qm74 5725 6 ECMO ECMO NNP cord-015021-pol2qm74 5725 7 , , , cord-015021-pol2qm74 5725 8 heparin heparin JJ cord-015021-pol2qm74 5725 9 infusion infusion NN cord-015021-pol2qm74 5725 10 was be VBD cord-015021-pol2qm74 5725 11 interrupted interrupt VBN cord-015021-pol2qm74 5725 12 . . . cord-015021-pol2qm74 5726 1 No no DT cord-015021-pol2qm74 5726 2 severe severe JJ cord-015021-pol2qm74 5726 3 bleeding bleeding JJ cord-015021-pol2qm74 5726 4 complications complication NNS cord-015021-pol2qm74 5726 5 related relate VBN cord-015021-pol2qm74 5726 6 to to IN cord-015021-pol2qm74 5726 7 anticoagulation anticoagulation NN cord-015021-pol2qm74 5726 8 for for IN cord-015021-pol2qm74 5726 9 the the DT cord-015021-pol2qm74 5726 10 extracorporeal extracorporeal JJ cord-015021-pol2qm74 5726 11 bypass bypass NN cord-015021-pol2qm74 5726 12 could could MD cord-015021-pol2qm74 5726 13 be be VB cord-015021-pol2qm74 5726 14 observed observe VBN cord-015021-pol2qm74 5726 15 , , , cord-015021-pol2qm74 5726 16 however however RB cord-015021-pol2qm74 5726 17 , , , cord-015021-pol2qm74 5726 18 in in IN cord-015021-pol2qm74 5726 19 some some DT cord-015021-pol2qm74 5726 20 patients patient NNS cord-015021-pol2qm74 5726 21 , , , cord-015021-pol2qm74 5726 22 after after IN cord-015021-pol2qm74 5726 23 three three CD cord-015021-pol2qm74 5726 24 weeks week NNS cord-015021-pol2qm74 5726 25 of of IN cord-015021-pol2qm74 5726 26 ECMO ECMO NNP cord-015021-pol2qm74 5726 27 thrombi thrombi NNP cord-015021-pol2qm74 5726 28 in in IN cord-015021-pol2qm74 5726 29 the the DT cord-015021-pol2qm74 5726 30 drainage drainage NN cord-015021-pol2qm74 5726 31 cannula cannula NN cord-015021-pol2qm74 5726 32 were be VBD cord-015021-pol2qm74 5726 33 observed observe VBN cord-015021-pol2qm74 5726 34 . . . cord-015021-pol2qm74 5727 1 A a DT cord-015021-pol2qm74 5727 2 problem problem NN cord-015021-pol2qm74 5727 3 of of IN cord-015021-pol2qm74 5727 4 of of IN cord-015021-pol2qm74 5727 5 membrane membrane NN cord-015021-pol2qm74 5727 6 leakage leakage NN cord-015021-pol2qm74 5727 7 shortened shorten VBD cord-015021-pol2qm74 5727 8 the the DT cord-015021-pol2qm74 5727 9 life life NN cord-015021-pol2qm74 5727 10 span span NN cord-015021-pol2qm74 5727 11 of of IN cord-015021-pol2qm74 5727 12 the the DT cord-015021-pol2qm74 5727 13 membrane membrane NN cord-015021-pol2qm74 5727 14 lungs lung VBZ cord-015021-pol2qm74 5727 15 to to IN cord-015021-pol2qm74 5727 16 a a DT cord-015021-pol2qm74 5727 17 mean mean NN cord-015021-pol2qm74 5727 18 of of IN cord-015021-pol2qm74 5727 19 about about RB cord-015021-pol2qm74 5727 20 four four CD cord-015021-pol2qm74 5727 21 4 4 CD cord-015021-pol2qm74 5727 22 days day NNS cord-015021-pol2qm74 5727 23 . . . cord-015021-pol2qm74 5728 1 In in IN cord-015021-pol2qm74 5728 2 the the DT cord-015021-pol2qm74 5728 3 conventionally conventionally RB cord-015021-pol2qm74 5728 4 treated treat VBN cord-015021-pol2qm74 5728 5 group group NN cord-015021-pol2qm74 5728 6 87 87 CD cord-015021-pol2qm74 5728 7 % % NN cord-015021-pol2qm74 5728 8 survived survive VBD cord-015021-pol2qm74 5728 9 and and CC cord-015021-pol2qm74 5728 10 in in IN cord-015021-pol2qm74 5728 11 the the DT cord-015021-pol2qm74 5728 12 additionally additionally RB cord-015021-pol2qm74 5728 13 with with IN cord-015021-pol2qm74 5728 14 ECMO ECMO NNP cord-015021-pol2qm74 5728 15 treated treat VBN cord-015021-pol2qm74 5728 16 group group NN cord-015021-pol2qm74 5728 17 58 58 CD cord-015021-pol2qm74 5728 18 % % NN cord-015021-pol2qm74 5728 19 survived survive VBD cord-015021-pol2qm74 5728 20 , , , cord-015021-pol2qm74 5728 21 representing represent VBG cord-015021-pol2qm74 5728 22 a a DT cord-015021-pol2qm74 5728 23 75 75 CD cord-015021-pol2qm74 5728 24 % % NN cord-015021-pol2qm74 5728 25 survival survival NN cord-015021-pol2qm74 5728 26 rate rate NN cord-015021-pol2qm74 5728 27 in in IN cord-015021-pol2qm74 5728 28 patients patient NNS cord-015021-pol2qm74 5728 29 whose whose WP$ cord-015021-pol2qm74 5728 30 risk risk NN cord-015021-pol2qm74 5728 31 of of IN cord-015021-pol2qm74 5728 32 death death NN cord-015021-pol2qm74 5728 33 is be VBZ cord-015021-pol2qm74 5728 34 considered consider VBN cord-015021-pol2qm74 5728 35 more more JJR cord-015021-pol2qm74 5728 36 than than IN cord-015021-pol2qm74 5728 37 50 50 CD cord-015021-pol2qm74 5728 38 % % NN cord-015021-pol2qm74 5728 39 . . . cord-015021-pol2qm74 5729 1 On on IN cord-015021-pol2qm74 5729 2 the the DT cord-015021-pol2qm74 5729 3 basis basis NN cord-015021-pol2qm74 5729 4 of of IN cord-015021-pol2qm74 5729 5 these these DT cord-015021-pol2qm74 5729 6 experiences experience NNS cord-015021-pol2qm74 5729 7 , , , cord-015021-pol2qm74 5729 8 we -PRON- PRP cord-015021-pol2qm74 5729 9 conclude conclude VBP cord-015021-pol2qm74 5729 10 that that IN cord-015021-pol2qm74 5729 11 the the DT cord-015021-pol2qm74 5729 12 described describe VBN cord-015021-pol2qm74 5729 13 strategy strategy NN cord-015021-pol2qm74 5729 14 , , , cord-015021-pol2qm74 5729 15 including include VBG cord-015021-pol2qm74 5729 16 veno veno NN cord-015021-pol2qm74 5729 17 - - HYPH cord-015021-pol2qm74 5729 18 venous venous JJ cord-015021-pol2qm74 5729 19 ECMO ECMO NNP cord-015021-pol2qm74 5729 20 with with IN cord-015021-pol2qm74 5729 21 heparin heparin NN cord-015021-pol2qm74 5729 22 - - HYPH cord-015021-pol2qm74 5729 23 coeted coete VBN cord-015021-pol2qm74 5729 24 systems system NNS cord-015021-pol2qm74 5729 25 , , , cord-015021-pol2qm74 5729 26 may may MD cord-015021-pol2qm74 5729 27 improve improve VB cord-015021-pol2qm74 5729 28 the the DT cord-015021-pol2qm74 5729 29 survival survival NN cord-015021-pol2qm74 5729 30 in in IN cord-015021-pol2qm74 5729 31 patients patient NNS cord-015021-pol2qm74 5729 32 suffering suffer VBG cord-015021-pol2qm74 5729 33 from from IN cord-015021-pol2qm74 5729 34 severe severe JJ cord-015021-pol2qm74 5729 35 ARDS ARDS NNP cord-015021-pol2qm74 5729 36 . . . cord-015021-pol2qm74 5730 1 Abnormally abnormally RB cord-015021-pol2qm74 5730 2 high high JJ cord-015021-pol2qm74 5730 3 skeletal skeletal JJ cord-015021-pol2qm74 5730 4 muscle muscle NN cord-015021-pol2qm74 5730 5 pO po NN cord-015021-pol2qm74 5730 6 2 2 CD cord-015021-pol2qm74 5730 7 in in IN cord-015021-pol2qm74 5730 8 septic septic JJ cord-015021-pol2qm74 5730 9 patients patient NNS cord-015021-pol2qm74 5730 10 and and CC cord-015021-pol2qm74 5730 11 its -PRON- PRP$ cord-015021-pol2qm74 5730 12 normalization normalization NN cord-015021-pol2qm74 5730 13 during during IN cord-015021-pol2qm74 5730 14 recovery recovery NN cord-015021-pol2qm74 5730 15 : : : cord-015021-pol2qm74 5730 16 Evidence evidence NN cord-015021-pol2qm74 5730 17 against against IN cord-015021-pol2qm74 5730 18 tissue tissue NN cord-015021-pol2qm74 5730 19 hypoxia hypoxia NN cord-015021-pol2qm74 5730 20 but but CC cord-015021-pol2qm74 5730 21 for for IN cord-015021-pol2qm74 5730 22 impaired impaired JJ cord-015021-pol2qm74 5730 23 oxygen oxygen NN cord-015021-pol2qm74 5730 24 metabolism metabolism NN cord-015021-pol2qm74 5730 25 of of IN cord-015021-pol2qm74 5730 26 skeletal skeletal JJ cord-015021-pol2qm74 5730 27 muscle muscle NN cord-015021-pol2qm74 5730 28 ? ? . cord-015021-pol2qm74 5731 1 P. P. NNP cord-015021-pol2qm74 5731 2 Boekstegers Boekstegers NNP cord-015021-pol2qm74 5731 3 , , , cord-015021-pol2qm74 5731 4 K. K. NNP cord-015021-pol2qm74 5731 5 Werdan Werdan NNP cord-015021-pol2qm74 5731 6 Department Department NNP cord-015021-pol2qm74 5731 7 of of IN cord-015021-pol2qm74 5731 8 Medicine Medicine NNP cord-015021-pol2qm74 5732 1 I -PRON- PRP cord-015021-pol2qm74 5732 2 , , , cord-015021-pol2qm74 5732 3 Gro6hadern Gro6hadern NNP cord-015021-pol2qm74 5732 4 University University NNP cord-015021-pol2qm74 5732 5 Hospital Hospital NNP cord-015021-pol2qm74 5732 6 , , , cord-015021-pol2qm74 5732 7 Munich Munich NNP cord-015021-pol2qm74 5732 8 , , , cord-015021-pol2qm74 5732 9 Germany Germany NNP cord-015021-pol2qm74 5733 1 A a DT cord-015021-pol2qm74 5733 2 pathological pathological JJ cord-015021-pol2qm74 5733 3 oxygen oxygen NN cord-015021-pol2qm74 5733 4 uptake uptake NN cord-015021-pol2qm74 5733 5 supply supply NN cord-015021-pol2qm74 5733 6 dependence dependence NN cord-015021-pol2qm74 5733 7 was be VBD cord-015021-pol2qm74 5733 8 suggested suggest VBN cord-015021-pol2qm74 5733 9 to to TO cord-015021-pol2qm74 5733 10 indicate indicate VB cord-015021-pol2qm74 5733 11 tissue tissue NN cord-015021-pol2qm74 5733 12 hypoxia hypoxia NN cord-015021-pol2qm74 5733 13 in in IN cord-015021-pol2qm74 5733 14 sepsis sepsis NN cord-015021-pol2qm74 5733 15 - - : cord-015021-pol2qm74 5733 16 a a DT cord-015021-pol2qm74 5733 17 hypothesis hypothesis NN cord-015021-pol2qm74 5733 18 which which WDT cord-015021-pol2qm74 5733 19 is be VBZ cord-015021-pol2qm74 5733 20 discussed discuss VBN cord-015021-pol2qm74 5733 21 controversially controversially RB cord-015021-pol2qm74 5733 22 . . . cord-015021-pol2qm74 5734 1 Because because IN cord-015021-pol2qm74 5734 2 the the DT cord-015021-pol2qm74 5734 3 detection detection NN cord-015021-pol2qm74 5734 4 of of IN cord-015021-pol2qm74 5734 5 reduced reduce VBN cord-015021-pol2qm74 5734 6 oxygen oxygen NN cord-015021-pol2qm74 5734 7 transport transport NN cord-015021-pol2qm74 5734 8 to to IN cord-015021-pol2qm74 5734 9 tissue tissue NN cord-015021-pol2qm74 5734 10 and and CC cord-015021-pol2qm74 5734 11 & & CC cord-015021-pol2qm74 5734 12 tissue tissue NN cord-015021-pol2qm74 5734 13 hypoxia hypoxia NN cord-015021-pol2qm74 5734 14 would would MD cord-015021-pol2qm74 5734 15 have have VB cord-015021-pol2qm74 5734 16 important important JJ cord-015021-pol2qm74 5734 17 implications implication NNS cord-015021-pol2qm74 5734 18 for for IN cord-015021-pol2qm74 5734 19 therapy therapy NN cord-015021-pol2qm74 5734 20 , , , cord-015021-pol2qm74 5734 21 skeletal skeletal JJ cord-015021-pol2qm74 5734 22 muscle muscle NN cord-015021-pol2qm74 5734 23 oxygenation oxygenation NN cord-015021-pol2qm74 5734 24 was be VBD cord-015021-pol2qm74 5734 25 studied study VBN cord-015021-pol2qm74 5734 26 in in IN cord-015021-pol2qm74 5734 27 patients patient NNS cord-015021-pol2qm74 5734 28 with with IN cord-015021-pol2qm74 5734 29 sepsis sepsis NN cord-015021-pol2qm74 5734 30 . . . cord-015021-pol2qm74 5735 1 Intermittent intermittent JJ cord-015021-pol2qm74 5735 2 and and CC cord-015021-pol2qm74 5735 3 continuous continuous JJ cord-015021-pol2qm74 5735 4 determination determination NN cord-015021-pol2qm74 5735 5 of of IN cord-015021-pol2qm74 5735 6 skeletal skeletal JJ cord-015021-pol2qm74 5735 7 muscle muscle NN cord-015021-pol2qm74 5735 8 pO po NN cord-015021-pol2qm74 5735 9 2 2 CD cord-015021-pol2qm74 5735 10 by by IN cord-015021-pol2qm74 5735 11 polarographic polarographic JJ cord-015021-pol2qm74 5735 12 needle needle NN cord-015021-pol2qm74 5735 13 or or CC cord-015021-pol2qm74 5735 14 catheter catheter NN cord-015021-pol2qm74 5735 15 probes probe NNS cord-015021-pol2qm74 5735 16 provided provide VBD cord-015021-pol2qm74 5735 17 no no DT cord-015021-pol2qm74 5735 18 evidence evidence NN cord-015021-pol2qm74 5735 19 for for IN cord-015021-pol2qm74 5735 20 skeletal skeletal JJ cord-015021-pol2qm74 5735 21 muscle muscle NN cord-015021-pol2qm74 5735 22 hypoxia hypoxia NN cord-015021-pol2qm74 5735 23 even even RB cord-015021-pol2qm74 5735 24 in in IN cord-015021-pol2qm74 5735 25 severe severe JJ cord-015021-pol2qm74 5735 26 stage stage NN cord-015021-pol2qm74 5735 27 of of IN cord-015021-pol2qm74 5735 28 sepsis sepsis NN cord-015021-pol2qm74 5736 1 ( ( -LRB- cord-015021-pol2qm74 5736 2 Boekstegers Boekstegers NNP cord-015021-pol2qm74 5736 3 et et NNP cord-015021-pol2qm74 5736 4 al al NNP cord-015021-pol2qm74 5736 5 . . NNP cord-015021-pol2qm74 5736 6 , , , cord-015021-pol2qm74 5737 1 Crit Crit NNP cord-015021-pol2qm74 5737 2 Care Care NNP cord-015021-pol2qm74 5737 3 Med Med NNP cord-015021-pol2qm74 5737 4 1994 1994 CD cord-015021-pol2qm74 5737 5 ) ) -RRB- cord-015021-pol2qm74 5737 6 . . . cord-015021-pol2qm74 5738 1 In in IN cord-015021-pol2qm74 5738 2 contrast contrast NN cord-015021-pol2qm74 5738 3 , , , cord-015021-pol2qm74 5738 4 mean mean JJ cord-015021-pol2qm74 5738 5 skeletal skeletal JJ cord-015021-pol2qm74 5738 6 muscle muscle NN cord-015021-pol2qm74 5738 7 pO po NN cord-015021-pol2qm74 5738 8 2 2 CD cord-015021-pol2qm74 5738 9 was be VBD cord-015021-pol2qm74 5738 10 found find VBN cord-015021-pol2qm74 5738 11 to to TO cord-015021-pol2qm74 5738 12 be be VB cord-015021-pol2qm74 5738 13 abnormally abnormally RB cord-015021-pol2qm74 5738 14 high high JJ cord-015021-pol2qm74 5738 15 in in IN cord-015021-pol2qm74 5738 16 patients patient NNS cord-015021-pol2qm74 5738 17 with with IN cord-015021-pol2qm74 5738 18 sepsis sepsis NN cord-015021-pol2qm74 5738 19 ( ( -LRB- cord-015021-pol2qm74 5738 20 48 48 CD cord-015021-pol2qm74 5738 21 _ _ NN cord-015021-pol2qm74 5738 22 + + CC cord-015021-pol2qm74 5738 23 10,4 10,4 CD cord-015021-pol2qm74 5738 24 mmHg mmHg NNS cord-015021-pol2qm74 5738 25 , , , cord-015021-pol2qm74 5738 26 n=39 n=39 NNP cord-015021-pol2qm74 5738 27 ) ) -RRB- cord-015021-pol2qm74 5738 28 compared compare VBN cord-015021-pol2qm74 5738 29 to to IN cord-015021-pol2qm74 5738 30 patients patient NNS cord-015021-pol2qm74 5738 31 with with IN cord-015021-pol2qm74 5738 32 limited limited JJ cord-015021-pol2qm74 5738 33 infection infection NN cord-015021-pol2qm74 5738 34 ( ( -LRB- cord-015021-pol2qm74 5738 35 28 28 CD cord-015021-pol2qm74 5738 36 , , , cord-015021-pol2qm74 5738 37 4 4 CD cord-015021-pol2qm74 5738 38 + + SYM cord-015021-pol2qm74 5738 39 4 4 CD cord-015021-pol2qm74 5738 40 , , , cord-015021-pol2qm74 5738 41 7 7 CD cord-015021-pol2qm74 5738 42 mmHg mmHg NNS cord-015021-pol2qm74 5738 43 , , , cord-015021-pol2qm74 5738 44 p<0.001 p<0.001 CD cord-015021-pol2qm74 5738 45 , , , cord-015021-pol2qm74 5738 46 n=16 n=16 NNP cord-015021-pol2qm74 5738 47 ) ) -RRB- cord-015021-pol2qm74 5738 48 , , , cord-015021-pol2qm74 5738 49 to to IN cord-015021-pol2qm74 5738 50 patients patient NNS cord-015021-pol2qm74 5738 51 with with IN cord-015021-pol2qm74 5738 52 cardiogenic cardiogenic JJ cord-015021-pol2qm74 5738 53 shock shock NN cord-015021-pol2qm74 5738 54 ( ( -LRB- cord-015021-pol2qm74 5738 55 22,3 22,3 CD cord-015021-pol2qm74 5738 56 + + SYM cord-015021-pol2qm74 5738 57 6,2 6,2 CD cord-015021-pol2qm74 5738 58 mmHg mmHg NNS cord-015021-pol2qm74 5738 59 , , , cord-015021-pol2qm74 5738 60 p<0.001 p<0.001 CD cord-015021-pol2qm74 5738 61 , , , cord-015021-pol2qm74 5738 62 n n NN cord-015021-pol2qm74 5738 63 = = NN cord-015021-pol2qm74 5738 64 lS ls NN cord-015021-pol2qm74 5738 65 ) ) -RRB- cord-015021-pol2qm74 5738 66 and and CC cord-015021-pol2qm74 5738 67 to to IN cord-015021-pol2qm74 5738 68 healthy healthy JJ cord-015021-pol2qm74 5738 69 subjects subject NNS cord-015021-pol2qm74 5738 70 ( ( -LRB- cord-015021-pol2qm74 5738 71 33,3 33,3 CD cord-015021-pol2qm74 5738 72 _ _ NN cord-015021-pol2qm74 5738 73 + + CC cord-015021-pol2qm74 5738 74 8,1 8,1 CD cord-015021-pol2qm74 5738 75 mmHg mmHg NNS cord-015021-pol2qm74 5738 76 , , , cord-015021-pol2qm74 5738 77 p<0.001 p<0.001 CD cord-015021-pol2qm74 5738 78 , , , cord-015021-pol2qm74 5738 79 n=10 n=10 NNP cord-015021-pol2qm74 5738 80 ) ) -RRB- cord-015021-pol2qm74 5738 81 . . . cord-015021-pol2qm74 5739 1 Furthermore furthermore RB cord-015021-pol2qm74 5739 2 , , , cord-015021-pol2qm74 5739 3 serial serial JJ cord-015021-pol2qm74 5739 4 measurements measurement NNS cord-015021-pol2qm74 5739 5 in in IN cord-015021-pol2qm74 5739 6 patients patient NNS cord-015021-pol2qm74 5739 7 with with IN cord-015021-pol2qm74 5739 8 sepsis sepsis NN cord-015021-pol2qm74 5739 9 showed show VBD cord-015021-pol2qm74 5739 10 that that IN cord-015021-pol2qm74 5739 11 skeletal skeletal JJ cord-015021-pol2qm74 5739 12 muscle muscle NN cord-015021-pol2qm74 5739 13 pO po NN cord-015021-pol2qm74 5739 14 2 2 CD cord-015021-pol2qm74 5739 15 was be VBD cord-015021-pol2qm74 5739 16 higher high JJR cord-015021-pol2qm74 5740 1 ( ( -LRB- cord-015021-pol2qm74 5740 2 44,1 44,1 CD cord-015021-pol2qm74 5740 3 _ _ NN cord-015021-pol2qm74 5740 4 + + SYM cord-015021-pol2qm74 5740 5 10,3 10,3 CD cord-015021-pol2qm74 5740 6 mmHg mmHg NNS cord-015021-pol2qm74 5740 7 ) ) -RRB- cord-015021-pol2qm74 5740 8 on on IN cord-015021-pol2qm74 5740 9 days day NNS cord-015021-pol2qm74 5740 10 with with IN cord-015021-pol2qm74 5740 11 severe severe JJ cord-015021-pol2qm74 5740 12 sepsis sepsis NN cord-015021-pol2qm74 5741 1 than than IN cord-015021-pol2qm74 5741 2 on on IN cord-015021-pol2qm74 5741 3 days day NNS cord-015021-pol2qm74 5741 4 with with IN cord-015021-pol2qm74 5741 5 intermediate intermediate JJ cord-015021-pol2qm74 5741 6 state state NN cord-015021-pol2qm74 5741 7 ( ( -LRB- cord-015021-pol2qm74 5741 8 30,1 30,1 CD cord-015021-pol2qm74 5741 9 _ _ NN cord-015021-pol2qm74 5741 10 + + SYM cord-015021-pol2qm74 5741 11 8 8 CD cord-015021-pol2qm74 5741 12 mmHg mmHg NNS cord-015021-pol2qm74 5741 13 ) ) -RRB- cord-015021-pol2qm74 5741 14 and and CC cord-015021-pol2qm74 5741 15 than than IN cord-015021-pol2qm74 5741 16 on on IN cord-015021-pol2qm74 5741 17 days day NNS cord-015021-pol2qm74 5741 18 without without IN cord-015021-pol2qm74 5741 19 sepsis sepsis NN cord-015021-pol2qm74 5741 20 ( ( -LRB- cord-015021-pol2qm74 5741 21 26 26 CD cord-015021-pol2qm74 5741 22 , , , cord-015021-pol2qm74 5741 23 8 8 CD cord-015021-pol2qm74 5741 24 _ _ NN cord-015021-pol2qm74 5741 25 + + SYM cord-015021-pol2qm74 5741 26 5 5 CD cord-015021-pol2qm74 5741 27 , , , cord-015021-pol2qm74 5741 28 I -PRON- PRP cord-015021-pol2qm74 5741 29 mmHg mmHg NNP cord-015021-pol2qm74 5741 30 ) ) -RRB- cord-015021-pol2qm74 5741 31 . . . cord-015021-pol2qm74 5742 1 Thus thus RB cord-015021-pol2qm74 5742 2 , , , cord-015021-pol2qm74 5742 3 a a DT cord-015021-pol2qm74 5742 4 decrease decrease NN cord-015021-pol2qm74 5742 5 of of IN cord-015021-pol2qm74 5742 6 abnormally abnormally RB cord-015021-pol2qm74 5742 7 high high JJ cord-015021-pol2qm74 5742 8 skeletal skeletal JJ cord-015021-pol2qm74 5742 9 muscle muscle NN cord-015021-pol2qm74 5742 10 pO po NN cord-015021-pol2qm74 5742 11 2 2 CD cord-015021-pol2qm74 5742 12 was be VBD cord-015021-pol2qm74 5742 13 related relate VBN cord-015021-pol2qm74 5742 14 to to IN cord-015021-pol2qm74 5742 15 improvement improvement NN cord-015021-pol2qm74 5742 16 of of IN cord-015021-pol2qm74 5742 17 sepsis sepsis NN cord-015021-pol2qm74 5742 18 . . . cord-015021-pol2qm74 5743 1 This this DT cord-015021-pol2qm74 5743 2 was be VBD cord-015021-pol2qm74 5743 3 also also RB cord-015021-pol2qm74 5743 4 demonstrated demonstrate VBN cord-015021-pol2qm74 5743 5 by by IN cord-015021-pol2qm74 5743 6 comparing compare VBG cord-015021-pol2qm74 5743 7 the the DT cord-015021-pol2qm74 5743 8 decrease decrease NN cord-015021-pol2qm74 5743 9 of of IN cord-015021-pol2qm74 5743 10 abnormally abnormally RB cord-015021-pol2qm74 5743 11 high high JJ cord-015021-pol2qm74 5743 12 skeletal skeletal JJ cord-015021-pol2qm74 5743 13 muscle muscle NN cord-015021-pol2qm74 5743 14 pO po NN cord-015021-pol2qm74 5743 15 2 2 CD cord-015021-pol2qm74 5743 16 with with IN cord-015021-pol2qm74 5743 17 the the DT cord-015021-pol2qm74 5743 18 decrease decrease NN cord-015021-pol2qm74 5743 19 of of IN cord-015021-pol2qm74 5743 20 APACHE APACHE NNP cord-015021-pol2qm74 5743 21 II II NNP cord-015021-pol2qm74 5743 22 score score NN cord-015021-pol2qm74 5743 23 or or CC cord-015021-pol2qm74 5743 24 Elebute Elebute NNP cord-015021-pol2qm74 5743 25 score score NN cord-015021-pol2qm74 5743 26 as as RB cord-015021-pol2qm74 5743 27 well well RB cord-015021-pol2qm74 5743 28 as as IN cord-015021-pol2qm74 5743 29 Interleukin-6 Interleukin-6 NNP cord-015021-pol2qm74 5743 30 serum serum NN cord-015021-pol2qm74 5743 31 levels level NNS cord-015021-pol2qm74 5743 32 in in IN cord-015021-pol2qm74 5743 33 a a DT cord-015021-pol2qm74 5743 34 separate separate JJ cord-015021-pol2qm74 5743 35 study study NN cord-015021-pol2qm74 5743 36 ( ( -LRB- cord-015021-pol2qm74 5743 37 Boekstegers Boekstegers NNP cord-015021-pol2qm74 5743 38 et et NNP cord-015021-pol2qm74 5743 39 el el NNP cord-015021-pol2qm74 5743 40 . . NNP cord-015021-pol2qm74 5743 41 , , , cord-015021-pol2qm74 5743 42 Shock Shock NNP cord-015021-pol2qm74 5743 43 , , , cord-015021-pol2qm74 5743 44 in in IN cord-015021-pol2qm74 5743 45 press press NN cord-015021-pol2qm74 5743 46 ) ) -RRB- cord-015021-pol2qm74 5743 47 . . . cord-015021-pol2qm74 5744 1 In in IN cord-015021-pol2qm74 5744 2 summary summary NN cord-015021-pol2qm74 5744 3 , , , cord-015021-pol2qm74 5744 4 our -PRON- PRP$ cord-015021-pol2qm74 5744 5 data datum NNS cord-015021-pol2qm74 5744 6 provide provide VBP cord-015021-pol2qm74 5744 7 no no DT cord-015021-pol2qm74 5744 8 evidence evidence NN cord-015021-pol2qm74 5744 9 for for IN cord-015021-pol2qm74 5744 10 skeletal skeletal JJ cord-015021-pol2qm74 5744 11 muscle muscle NN cord-015021-pol2qm74 5744 12 hypoxia hypoxia NN cord-015021-pol2qm74 5744 13 in in IN cord-015021-pol2qm74 5744 14 patients patient NNS cord-015021-pol2qm74 5744 15 with with IN cord-015021-pol2qm74 5744 16 sepsis sepsis NN cord-015021-pol2qm74 5744 17 but but CC cord-015021-pol2qm74 5744 18 support support VBP cord-015021-pol2qm74 5744 19 the the DT cord-015021-pol2qm74 5744 20 assumption assumption NN cord-015021-pol2qm74 5744 21 & & CC cord-015021-pol2qm74 5744 22 impaired impair VBN cord-015021-pol2qm74 5744 23 oxygen oxygen NN cord-015021-pol2qm74 5744 24 metabolism metabolism NN cord-015021-pol2qm74 5744 25 in in IN cord-015021-pol2qm74 5744 26 severe severe JJ cord-015021-pol2qm74 5744 27 sepsis sepsis NN cord-015021-pol2qm74 5744 28 . . . cord-015021-pol2qm74 5745 1 NeutropNlic NeutropNlic NNP cord-015021-pol2qm74 5745 2 emigration emigration NN cord-015021-pol2qm74 5745 3 from from IN cord-015021-pol2qm74 5745 4 the the DT cord-015021-pol2qm74 5745 5 vascular vascular JJ cord-015021-pol2qm74 5745 6 space space NN cord-015021-pol2qm74 5745 7 into into IN cord-015021-pol2qm74 5745 8 the the DT cord-015021-pol2qm74 5745 9 extracellular extracellular JJ cord-015021-pol2qm74 5745 10 matrix matrix NN cord-015021-pol2qm74 5745 11 is be VBZ cord-015021-pol2qm74 5745 12 important important JJ cord-015021-pol2qm74 5745 13 for for IN cord-015021-pol2qm74 5745 14 the the DT cord-015021-pol2qm74 5745 15 response response NN cord-015021-pol2qm74 5745 16 to to TO cord-015021-pol2qm74 5745 17 tissue tissue NN cord-015021-pol2qm74 5745 18 injury injury NN cord-015021-pol2qm74 5745 19 or or CC cord-015021-pol2qm74 5745 20 contamination contamination NN cord-015021-pol2qm74 5745 21 by by IN cord-015021-pol2qm74 5745 22 providing provide VBG cord-015021-pol2qm74 5745 23 a a DT cord-015021-pol2qm74 5745 24 large large JJ cord-015021-pol2qm74 5745 25 recruitable recruitable JJ cord-015021-pol2qm74 5745 26 pool pool NN cord-015021-pol2qm74 5745 27 of of IN cord-015021-pol2qm74 5745 28 tissue tissue NN cord-015021-pol2qm74 5745 29 - - HYPH cord-015021-pol2qm74 5745 30 based base VBN cord-015021-pol2qm74 5745 31 phagocytes phagocyte NNS cord-015021-pol2qm74 5745 32 . . . cord-015021-pol2qm74 5746 1 The the DT cord-015021-pol2qm74 5746 2 consequences consequence NNS cord-015021-pol2qm74 5746 3 of of IN cord-015021-pol2qm74 5746 4 neutrophil neutrophil NN cord-015021-pol2qm74 5746 5 exposure exposure NN cord-015021-pol2qm74 5746 6 to to IN cord-015021-pol2qm74 5746 7 intravaseular intravaseular NNP cord-015021-pol2qm74 5746 8 chemoattractants chemoattractants NNP cord-015021-pol2qm74 5746 9 , , , cord-015021-pol2qm74 5746 10 likely likely RB cord-015021-pol2qm74 5746 11 relevant relevant JJ cord-015021-pol2qm74 5746 12 for for IN cord-015021-pol2qm74 5746 13 IL-8 IL-8 NNP cord-015021-pol2qm74 5746 14 and and CC cord-015021-pol2qm74 5746 15 C5a C5a NNS cord-015021-pol2qm74 5746 16 in in IN cord-015021-pol2qm74 5746 17 sepsis sepsis NN cord-015021-pol2qm74 5746 18 , , , cord-015021-pol2qm74 5746 19 trauma trauma NN cord-015021-pol2qm74 5746 20 , , , cord-015021-pol2qm74 5746 21 and and CC cord-015021-pol2qm74 5746 22 in in IN cord-015021-pol2qm74 5746 23 burn burn NN cord-015021-pol2qm74 5746 24 injury injury NN cord-015021-pol2qm74 5746 25 , , , cord-015021-pol2qm74 5746 26 are be VBP cord-015021-pol2qm74 5746 27 suppression suppression NN cord-015021-pol2qm74 5746 28 of of IN cord-015021-pol2qm74 5746 29 neutrophil neutrophil NN cord-015021-pol2qm74 5746 30 attachment attachment NN cord-015021-pol2qm74 5746 31 to to IN cord-015021-pol2qm74 5746 32 endothelial endothelial JJ cord-015021-pol2qm74 5746 33 cells cell NNS cord-015021-pol2qm74 5746 34 and and CC cord-015021-pol2qm74 5746 35 matrix matrix NN cord-015021-pol2qm74 5746 36 proteins protein NNS cord-015021-pol2qm74 5746 37 . . . cord-015021-pol2qm74 5747 1 It -PRON- PRP cord-015021-pol2qm74 5747 2 is be VBZ cord-015021-pol2qm74 5747 3 probable probable JJ cord-015021-pol2qm74 5747 4 that that IN cord-015021-pol2qm74 5747 5 proteoglycan proteoglycan NN cord-015021-pol2qm74 5747 6 - - HYPH cord-015021-pol2qm74 5747 7 bound bind VBN cord-015021-pol2qm74 5747 8 attractants attractant NNS cord-015021-pol2qm74 5747 9 are be VBP cord-015021-pol2qm74 5747 10 of of IN cord-015021-pol2qm74 5747 11 considerable considerable JJ cord-015021-pol2qm74 5747 12 biologic biologic JJ cord-015021-pol2qm74 5747 13 relevance relevance NN cord-015021-pol2qm74 5747 14 , , , cord-015021-pol2qm74 5747 15 and and CC cord-015021-pol2qm74 5747 16 may may MD cord-015021-pol2qm74 5747 17 result result VB cord-015021-pol2qm74 5747 18 in in IN cord-015021-pol2qm74 5747 19 enhancement enhancement NN cord-015021-pol2qm74 5747 20 of of IN cord-015021-pol2qm74 5747 21 responses response NNS cord-015021-pol2qm74 5747 22 to to TO cord-015021-pol2qm74 5747 23 subsequently subsequently RB cord-015021-pol2qm74 5747 24 encountered encounter VBD cord-015021-pol2qm74 5747 25 cytokines cytokine NNS cord-015021-pol2qm74 5747 26 . . . cord-015021-pol2qm74 5748 1 In in IN cord-015021-pol2qm74 5748 2 the the DT cord-015021-pol2qm74 5748 3 presence presence NN cord-015021-pol2qm74 5748 4 of of IN cord-015021-pol2qm74 5748 5 connective connective JJ cord-015021-pol2qm74 5748 6 tissue tissue NN cord-015021-pol2qm74 5748 7 proteins protein NNS cord-015021-pol2qm74 5748 8 expressing express VBG cord-015021-pol2qm74 5748 9 integrin integrin NN cord-015021-pol2qm74 5748 10 - - HYPH cord-015021-pol2qm74 5748 11 specific specific JJ cord-015021-pol2qm74 5748 12 binding bind VBG cord-015021-pol2qm74 5748 13 ligands ligand NNS cord-015021-pol2qm74 5748 14 , , , cord-015021-pol2qm74 5748 15 neutrophils neutrophil NNS cord-015021-pol2qm74 5748 16 respond respond VBP cord-015021-pol2qm74 5748 17 to to IN cord-015021-pol2qm74 5748 18 TNF TNF NNP cord-015021-pol2qm74 5748 19 - - HYPH cord-015021-pol2qm74 5748 20 cq cq NNP cord-015021-pol2qm74 5748 21 GM GM NNP cord-015021-pol2qm74 5748 22 - - HYPH cord-015021-pol2qm74 5748 23 CSF CSF NNP cord-015021-pol2qm74 5748 24 and and CC cord-015021-pol2qm74 5748 25 other other JJ cord-015021-pol2qm74 5748 26 cytokines cytokine NNS cord-015021-pol2qm74 5748 27 by by IN cord-015021-pol2qm74 5748 28 producing produce VBG cord-015021-pol2qm74 5748 29 large large JJ cord-015021-pol2qm74 5748 30 amounts amount NNS cord-015021-pol2qm74 5748 31 of of IN cord-015021-pol2qm74 5748 32 hydrogen hydrogen NN cord-015021-pol2qm74 5748 33 peroxide peroxide NN cord-015021-pol2qm74 5748 34 . . . cord-015021-pol2qm74 5749 1 This this DT cord-015021-pol2qm74 5749 2 response response NN cord-015021-pol2qm74 5749 3 is be VBZ cord-015021-pol2qm74 5749 4 likely likely RB cord-015021-pol2qm74 5749 5 important important JJ cord-015021-pol2qm74 5749 6 in in IN cord-015021-pol2qm74 5749 7 the the DT cord-015021-pol2qm74 5749 8 digestion digestion NN cord-015021-pol2qm74 5749 9 of of IN cord-015021-pol2qm74 5749 10 contaminated contaminate VBN cord-015021-pol2qm74 5749 11 or or CC cord-015021-pol2qm74 5749 12 injured injure VBN cord-015021-pol2qm74 5749 13 tissue tissue NN cord-015021-pol2qm74 5749 14 by by IN cord-015021-pol2qm74 5749 15 facilitating facilitate VBG cord-015021-pol2qm74 5749 16 activity activity NN cord-015021-pol2qm74 5749 17 of of IN cord-015021-pol2qm74 5749 18 neutrnphil neutrnphil NNP cord-015021-pol2qm74 5749 19 granular granular JJ cord-015021-pol2qm74 5749 20 proteases protease NNS cord-015021-pol2qm74 5749 21 and and CC cord-015021-pol2qm74 5749 22 inactivating inactivate VBG cord-015021-pol2qm74 5749 23 plasma plasma NN cord-015021-pol2qm74 5749 24 anti anti NNS cord-015021-pol2qm74 5749 25 - - NNS cord-015021-pol2qm74 5749 26 proteases protease NNS cord-015021-pol2qm74 5749 27 . . . cord-015021-pol2qm74 5750 1 This this DT cord-015021-pol2qm74 5750 2 matrix matrix NN cord-015021-pol2qm74 5750 3 - - HYPH cord-015021-pol2qm74 5750 4 dependent dependent JJ cord-015021-pol2qm74 5750 5 oxidative oxidative JJ cord-015021-pol2qm74 5750 6 response response NN cord-015021-pol2qm74 5750 7 is be VBZ cord-015021-pol2qm74 5750 8 important important JJ cord-015021-pol2qm74 5750 9 in in IN cord-015021-pol2qm74 5750 10 defining define VBG cord-015021-pol2qm74 5750 11 potential potential JJ cord-015021-pol2qm74 5750 12 novel novel NN cord-015021-pol2qm74 5750 13 targets target NNS cord-015021-pol2qm74 5750 14 for for IN cord-015021-pol2qm74 5750 15 therapeutic therapeutic JJ cord-015021-pol2qm74 5750 16 intervention intervention NN cord-015021-pol2qm74 5750 17 . . . cord-015021-pol2qm74 5751 1 The the DT cord-015021-pol2qm74 5751 2 response response NN cord-015021-pol2qm74 5751 3 appears appear VBZ cord-015021-pol2qm74 5751 4 to to TO cord-015021-pol2qm74 5751 5 involve involve VB cord-015021-pol2qm74 5751 6 signalling signal VBG cord-015021-pol2qm74 5751 7 by by IN cord-015021-pol2qm74 5751 8 integrin integrin NN cord-015021-pol2qm74 5751 9 - - HYPH cord-015021-pol2qm74 5751 10 linked link VBN cord-015021-pol2qm74 5751 11 tyrosine tyrosine NN cord-015021-pol2qm74 5751 12 kinases kinase NNS cord-015021-pol2qm74 5751 13 . . . cord-015021-pol2qm74 5752 1 The the DT cord-015021-pol2qm74 5752 2 net net JJ cord-015021-pol2qm74 5752 3 effect effect NN cord-015021-pol2qm74 5752 4 of of IN cord-015021-pol2qm74 5752 5 matrix matrix NN cord-015021-pol2qm74 5752 6 protein protein NN cord-015021-pol2qm74 5752 7 injury injury NN cord-015021-pol2qm74 5752 8 through through IN cord-015021-pol2qm74 5752 9 this this DT cord-015021-pol2qm74 5752 10 mechanism mechanism NN cord-015021-pol2qm74 5752 11 is be VBZ cord-015021-pol2qm74 5752 12 enhancement enhancement NN cord-015021-pol2qm74 5752 13 of of IN cord-015021-pol2qm74 5752 14 the the DT cord-015021-pol2qm74 5752 15 fibrotic fibrotic JJ cord-015021-pol2qm74 5752 16 response response NN cord-015021-pol2qm74 5752 17 which which WDT cord-015021-pol2qm74 5752 18 underlies underlie VBZ cord-015021-pol2qm74 5752 19 much much JJ cord-015021-pol2qm74 5752 20 of of IN cord-015021-pol2qm74 5752 21 the the DT cord-015021-pol2qm74 5752 22 prolonged prolong VBN cord-015021-pol2qm74 5752 23 ventilator ventilator NN cord-015021-pol2qm74 5752 24 dependence dependence NN cord-015021-pol2qm74 5752 25 of of IN cord-015021-pol2qm74 5752 26 patients patient NNS cord-015021-pol2qm74 5752 27 with with IN cord-015021-pol2qm74 5752 28 the the DT cord-015021-pol2qm74 5752 29 adult adult NN cord-015021-pol2qm74 5752 30 respiratory respiratory JJ cord-015021-pol2qm74 5752 31 distress distress NN cord-015021-pol2qm74 5752 32 syndrome syndrome NN cord-015021-pol2qm74 5752 33 . . . cord-015021-pol2qm74 5753 1 This this DT cord-015021-pol2qm74 5753 2 adherence adherence NN cord-015021-pol2qm74 5753 3 dependent dependent JJ cord-015021-pol2qm74 5753 4 response response NN cord-015021-pol2qm74 5753 5 has have VBZ cord-015021-pol2qm74 5753 6 also also RB cord-015021-pol2qm74 5753 7 been be VBN cord-015021-pol2qm74 5753 8 implicated implicate VBN cord-015021-pol2qm74 5753 9 in in IN cord-015021-pol2qm74 5753 10 direct direct JJ cord-015021-pol2qm74 5753 11 hepatocyte hepatocyte NN cord-015021-pol2qm74 5753 12 injury injury NN cord-015021-pol2qm74 5753 13 , , , cord-015021-pol2qm74 5753 14 and and CC cord-015021-pol2qm74 5753 15 may may MD cord-015021-pol2qm74 5753 16 represent represent VB cord-015021-pol2qm74 5753 17 an an DT cord-015021-pol2qm74 5753 18 early early JJ cord-015021-pol2qm74 5753 19 component component NN cord-015021-pol2qm74 5753 20 of of IN cord-015021-pol2qm74 5753 21 the the DT cord-015021-pol2qm74 5753 22 syndrome syndrome NN cord-015021-pol2qm74 5753 23 of of IN cord-015021-pol2qm74 5753 24 multisystem multisystem JJ cord-015021-pol2qm74 5753 25 organ organ NN cord-015021-pol2qm74 5753 26 failure failure NN cord-015021-pol2qm74 5753 27 . . . cord-015021-pol2qm74 5754 1 Study study NN cord-015021-pol2qm74 5754 2 purpose purpose NN cord-015021-pol2qm74 5754 3 : : : cord-015021-pol2qm74 5754 4 In in IN cord-015021-pol2qm74 5754 5 this this DT cord-015021-pol2qm74 5754 6 patient patient NN cord-015021-pol2qm74 5754 7 ( ( -LRB- cord-015021-pol2qm74 5754 8 pat pat NNP cord-015021-pol2qm74 5754 9 . . . cord-015021-pol2qm74 5754 10 ) ) -RRB- cord-015021-pol2qm74 5754 11 population population NN cord-015021-pol2qm74 5754 12 with with IN cord-015021-pol2qm74 5754 13 a a DT cord-015021-pol2qm74 5754 14 considerable considerable JJ cord-015021-pol2qm74 5754 15 sepsis sepsis NN cord-015021-pol2qm74 5754 16 morbidity morbidity NN cord-015021-pol2qm74 5754 17 and and CC cord-015021-pol2qm74 5754 18 mortality mortality NN cord-015021-pol2qm74 5754 19 , , , cord-015021-pol2qm74 5754 20 parameters parameter NNS cord-015021-pol2qm74 5754 21 proposed propose VBN cord-015021-pol2qm74 5754 22 for for IN cord-015021-pol2qm74 5754 23 sepsis sepsis NN cord-015021-pol2qm74 5754 24 assessment assessment NN cord-015021-pol2qm74 5754 25 ( ( -LRB- cord-015021-pol2qm74 5754 26 Elebute elebute NN cord-015021-pol2qm74 5754 27 sepsis sepsis NN cord-015021-pol2qm74 5754 28 score score NN cord-015021-pol2qm74 5754 29 [ [ -LRB- cord-015021-pol2qm74 5754 30 Ele Ele NNP cord-015021-pol2qm74 5754 31 ] ] -RRB- cord-015021-pol2qm74 5754 32 , , , cord-015021-pol2qm74 5754 33 SIRS SIRS NNP cord-015021-pol2qm74 5754 34 ) ) -RRB- cord-015021-pol2qm74 5754 35 were be VBD cord-015021-pol2qm74 5754 36 investigated investigate VBN cord-015021-pol2qm74 5754 37 with with IN cord-015021-pol2qm74 5754 38 regard regard NN cord-015021-pol2qm74 5754 39 to to IN cord-015021-pol2qm74 5754 40 their -PRON- PRP$ cord-015021-pol2qm74 5754 41 use use NN cord-015021-pol2qm74 5754 42 in in IN cord-015021-pol2qm74 5754 43 the the DT cord-015021-pol2qm74 5754 44 early early JJ cord-015021-pol2qm74 5754 45 classification classification NN cord-015021-pol2qm74 5754 46 of of IN cord-015021-pol2qm74 5754 47 pop pop NN cord-015021-pol2qm74 5754 48 . . . cord-015021-pol2qm74 5755 1 pat pat NNP cord-015021-pol2qm74 5755 2 . . . cord-015021-pol2qm74 5756 1 at at IN cord-015021-pol2qm74 5756 2 risk risk NN cord-015021-pol2qm74 5756 3 for for IN cord-015021-pol2qm74 5756 4 developing develop VBG cord-015021-pol2qm74 5756 5 sepsis sepsis NN cord-015021-pol2qm74 5756 6 . . . cord-015021-pol2qm74 5757 1 Patients patient NNS cord-015021-pol2qm74 5757 2 and and CC cord-015021-pol2qm74 5757 3 Methods method NNS cord-015021-pol2qm74 5757 4 : : : cord-015021-pol2qm74 5757 5 In in IN cord-015021-pol2qm74 5757 6 a a DT cord-015021-pol2qm74 5757 7 previous previous JJ cord-015021-pol2qm74 5757 8 observational observational JJ cord-015021-pol2qm74 5757 9 study study NN cord-015021-pol2qm74 5757 10 on on IN cord-015021-pol2qm74 5757 11 110 110 CD cord-015021-pol2qm74 5757 12 consecutive consecutive JJ cord-015021-pol2qm74 5757 13 pat pat NN cord-015021-pol2qm74 5757 14 . . . cord-015021-pol2qm74 5758 1 after after IN cord-015021-pol2qm74 5758 2 elective elective JJ cord-015021-pol2qm74 5758 3 open open JJ cord-015021-pol2qm74 5758 4 - - HYPH cord-015021-pol2qm74 5758 5 heart heart NN cord-015021-pol2qm74 5758 6 surgery surgery NN cord-015021-pol2qm74 5758 7 , , , cord-015021-pol2qm74 5758 8 we -PRON- PRP cord-015021-pol2qm74 5758 9 had have VBD cord-015021-pol2qm74 5758 10 determined determine VBN cord-015021-pol2qm74 5758 11 Ele Ele NNP cord-015021-pol2qm74 5758 12 daily daily RB cord-015021-pol2qm74 5758 13 for for IN cord-015021-pol2qm74 5758 14 at at RB cord-015021-pol2qm74 5758 15 least least JJS cord-015021-pol2qm74 5758 16 3 3 CD cord-015021-pol2qm74 5758 17 pop pop NN cord-015021-pol2qm74 5758 18 . . . cord-015021-pol2qm74 5759 1 days day NNS cord-015021-pol2qm74 5759 2 ( ( -LRB- cord-015021-pol2qm74 5759 3 in in IN cord-015021-pol2qm74 5759 4 pat pat NNP cord-015021-pol2qm74 5759 5 . . . cord-015021-pol2qm74 5760 1 with with IN cord-015021-pol2qm74 5760 2 a a DT cord-015021-pol2qm74 5760 3 longer long RBR cord-015021-pol2qm74 5760 4 stay stay NN cord-015021-pol2qm74 5760 5 : : : cord-015021-pol2qm74 5760 6 until until IN cord-015021-pol2qm74 5760 7 ICU ICU NNP cord-015021-pol2qm74 5760 8 discharge discharge NN cord-015021-pol2qm74 5760 9 ) ) -RRB- cord-015021-pol2qm74 5760 10 . . . cord-015021-pol2qm74 5761 1 After after IN cord-015021-pol2qm74 5761 2 publication publication NN cord-015021-pol2qm74 5761 3 of of IN cord-015021-pol2qm74 5761 4 the the DT cord-015021-pol2qm74 5761 5 newly newly RB cord-015021-pol2qm74 5761 6 proposed propose VBN cord-015021-pol2qm74 5761 7 SIRS sirs NN cord-015021-pol2qm74 5761 8 definition definition NN cord-015021-pol2qm74 5761 9 , , , cord-015021-pol2qm74 5761 10 these these DT cord-015021-pol2qm74 5761 11 criteria criterion NNS cord-015021-pol2qm74 5761 12 were be VBD cord-015021-pol2qm74 5761 13 retrospectively retrospectively RB cord-015021-pol2qm74 5761 14 calculated calculate VBN cord-015021-pol2qm74 5761 15 and and CC cord-015021-pol2qm74 5761 16 compared compare VBN cord-015021-pol2qm74 5761 17 to to IN cord-015021-pol2qm74 5761 18 Ele Ele NNP cord-015021-pol2qm74 5761 19 . . . cord-015021-pol2qm74 5762 1 Results result NNS cord-015021-pol2qm74 5762 2 : : : cord-015021-pol2qm74 5763 1 On on IN cord-015021-pol2qm74 5763 2 the the DT cord-015021-pol2qm74 5763 3 total total NN cord-015021-pol2qm74 5763 4 of of IN cord-015021-pol2qm74 5763 5 n n NN cord-015021-pol2qm74 5763 6 = = SYM cord-015021-pol2qm74 5763 7 515 515 CD cord-015021-pol2qm74 5763 8 patient patient NN cord-015021-pol2qm74 5763 9 - - HYPH cord-015021-pol2qm74 5763 10 days day NNS cord-015021-pol2qm74 5763 11 , , , cord-015021-pol2qm74 5763 12 both both CC cord-015021-pol2qm74 5763 13 Ele Ele NNP cord-015021-pol2qm74 5763 14 and and CC cord-015021-pol2qm74 5763 15 SIRS SIRS NNP cord-015021-pol2qm74 5763 16 showed show VBD cord-015021-pol2qm74 5763 17 significant significant JJ cord-015021-pol2qm74 5763 18 ( ( -LRB- cord-015021-pol2qm74 5763 19 p<0.0001 p<0.0001 NNP cord-015021-pol2qm74 5763 20 ) ) -RRB- cord-015021-pol2qm74 5763 21 correlations correlation NNS cord-015021-pol2qm74 5763 22 with with IN cord-015021-pol2qm74 5763 23 parameters parameter NNS cord-015021-pol2qm74 5763 24 reflecting reflect VBG cord-015021-pol2qm74 5763 25 the the DT cord-015021-pol2qm74 5763 26 general general JJ cord-015021-pol2qm74 5763 27 and and CC cord-015021-pol2qm74 5763 28 sepsis sepsis NN cord-015021-pol2qm74 5763 29 - - HYPH cord-015021-pol2qm74 5763 30 related relate VBN cord-015021-pol2qm74 5763 31 severity severity NN cord-015021-pol2qm74 5763 32 of of IN cord-015021-pol2qm74 5763 33 the the DT cord-015021-pol2qm74 5763 34 pop pop NN cord-015021-pol2qm74 5763 35 . . . cord-015021-pol2qm74 5764 1 clinical clinical JJ cord-015021-pol2qm74 5764 2 course course NN cord-015021-pol2qm74 5764 3 . . . cord-015021-pol2qm74 5765 1 Compared compare VBN cord-015021-pol2qm74 5765 2 to to IN cord-015021-pol2qm74 5765 3 SIRS SIRS NNP cord-015021-pol2qm74 5765 4 , , , cord-015021-pol2qm74 5765 5 the the DT cord-015021-pol2qm74 5765 6 Ele Ele NNP cord-015021-pol2qm74 5765 7 correlations correlation NNS cord-015021-pol2qm74 5765 8 were be VBD cord-015021-pol2qm74 5765 9 better well JJR cord-015021-pol2qm74 5765 10 ( ( -LRB- cord-015021-pol2qm74 5765 11 ICU ICU NNP cord-015021-pol2qm74 5765 12 mortality mortality NN cord-015021-pol2qm74 5765 13 : : : cord-015021-pol2qm74 5765 14 0.59 0.59 CD cord-015021-pol2qm74 5765 15 vs. vs. IN cord-015021-pol2qm74 5765 16 0.32 0.32 CD cord-015021-pol2qm74 5765 17 ; ; : cord-015021-pol2qm74 5765 18 ICU ICU NNP cord-015021-pol2qm74 5765 19 treatment treatment NN cord-015021-pol2qm74 5765 20 days day NNS cord-015021-pol2qm74 5765 21 : : : cord-015021-pol2qm74 5766 1 0,51 0,51 LS cord-015021-pol2qm74 5766 2 vs. vs. NN cord-015021-pol2qm74 5766 3 0.32 0.32 CD cord-015021-pol2qm74 5766 4 ; ; : cord-015021-pol2qm74 5766 5 days day NNS cord-015021-pol2qm74 5766 6 on on IN cord-015021-pol2qm74 5766 7 mechanical mechanical JJ cord-015021-pol2qm74 5766 8 ventilation ventilation NN cord-015021-pol2qm74 5766 9 : : : cord-015021-pol2qm74 5766 10 0,54 0,54 NNP cord-015021-pol2qm74 5766 11 vs. vs. FW cord-015021-pol2qm74 5766 12 0.32 0.32 CD cord-015021-pol2qm74 5766 13 ; ; : cord-015021-pol2qm74 5766 14 days day NNS cord-015021-pol2qm74 5766 15 with with IN cord-015021-pol2qm74 5766 16 vasopressor vasopressor NN cord-015021-pol2qm74 5766 17 requirement requirement NN cord-015021-pol2qm74 5766 18 : : : cord-015021-pol2qm74 5766 19 0.59 0.59 CD cord-015021-pol2qm74 5766 20 vs. vs. IN cord-015021-pol2qm74 5766 21 0.33 0.33 CD cord-015021-pol2qm74 5766 22 ; ; : cord-015021-pol2qm74 5766 23 number number NN cord-015021-pol2qm74 5766 24 of of IN cord-015021-pol2qm74 5766 25 microbiological microbiological JJ cord-015021-pol2qm74 5766 26 findings finding NNS cord-015021-pol2qm74 5766 27 : : : cord-015021-pol2qm74 5766 28 0.44 0.44 CD cord-015021-pol2qm74 5766 29 vs. vs. NN cord-015021-pol2qm74 5766 30 0.29 0.29 CD cord-015021-pol2qm74 5766 31 ) ) -RRB- cord-015021-pol2qm74 5767 1 , , , cord-015021-pol2qm74 5767 2 The the DT cord-015021-pol2qm74 5767 3 optimal optimal JJ cord-015021-pol2qm74 5767 4 classification classification NN cord-015021-pol2qm74 5767 5 criteria criterion NNS cord-015021-pol2qm74 5767 6 for for IN cord-015021-pol2qm74 5767 7 the the DT cord-015021-pol2qm74 5767 8 mainly mainly RB cord-015021-pol2qm74 5767 9 sepsis sepsis NN cord-015021-pol2qm74 5767 10 - - HYPH cord-015021-pol2qm74 5767 11 related relate VBN cord-015021-pol2qm74 5767 12 outcome outcome NN cord-015021-pol2qm74 5767 13 gave give VBD cord-015021-pol2qm74 5767 14 maximal maximal JJ cord-015021-pol2qm74 5767 15 Youden Youden NNP cord-015021-pol2qm74 5767 16 indices index NNS cord-015021-pol2qm74 5767 17 of of IN cord-015021-pol2qm74 5767 18 0.87 0.87 CD cord-015021-pol2qm74 5767 19 for for IN cord-015021-pol2qm74 5767 20 Ele Ele NNP cord-015021-pol2qm74 5767 21 ( ( -LRB- cord-015021-pol2qm74 5767 22 Ele ele NN cord-015021-pol2qm74 5767 23 > > XX cord-015021-pol2qm74 5768 1 _ _ NNP cord-015021-pol2qm74 5768 2 12 12 CD cord-015021-pol2qm74 5768 3 on on IN cord-015021-pol2qm74 5769 1 > > XX cord-015021-pol2qm74 5769 2 _ _ NN cord-015021-pol2qm74 5769 3 2 2 CD cord-015021-pol2qm74 5769 4 days day NNS cord-015021-pol2qm74 5769 5 , , , cord-015021-pol2qm74 5769 6 accuracy accuracy NN cord-015021-pol2qm74 5769 7 : : : cord-015021-pol2qm74 5769 8 94 94 CD cord-015021-pol2qm74 5769 9 % % NN cord-015021-pol2qm74 5769 10 ) ) -RRB- cord-015021-pol2qm74 5769 11 compared compare VBN cord-015021-pol2qm74 5769 12 to to IN cord-015021-pol2qm74 5769 13 0.42 0.42 CD cord-015021-pol2qm74 5769 14 for for IN cord-015021-pol2qm74 5769 15 SIRS SIRS NNP cord-015021-pol2qm74 5770 1 ( ( -LRB- cord-015021-pol2qm74 5770 2 SIRS sirs UH cord-015021-pol2qm74 5770 3 present present JJ cord-015021-pol2qm74 5770 4 on on IN cord-015021-pol2qm74 5770 5 > > $ cord-015021-pol2qm74 5770 6 3 3 CD cord-015021-pol2qm74 5770 7 days day NNS cord-015021-pol2qm74 5770 8 , , , cord-015021-pol2qm74 5770 9 accuracy accuracy NN cord-015021-pol2qm74 5770 10 : : : cord-015021-pol2qm74 5770 11 67 67 CD cord-015021-pol2qm74 5770 12 % % NN cord-015021-pol2qm74 5770 13 ) ) -RRB- cord-015021-pol2qm74 5770 14 . . . cord-015021-pol2qm74 5771 1 Accordingly accordingly RB cord-015021-pol2qm74 5771 2 , , , cord-015021-pol2qm74 5771 3 Ele Ele NNP cord-015021-pol2qm74 5771 4 ROC ROC NNP cord-015021-pol2qm74 5771 5 curve curve NN cord-015021-pol2qm74 5771 6 areas area NNS cord-015021-pol2qm74 5771 7 for for IN cord-015021-pol2qm74 5771 8 both both DT cord-015021-pol2qm74 5771 9 overall overall JJ cord-015021-pol2qm74 5771 10 ( ( -LRB- cord-015021-pol2qm74 5771 11 0.92 0.92 CD cord-015021-pol2qm74 5771 12 ) ) -RRB- cord-015021-pol2qm74 5771 13 as as RB cord-015021-pol2qm74 5771 14 well well RB cord-015021-pol2qm74 5771 15 as as IN cord-015021-pol2qm74 5771 16 sepsis sepsis NN cord-015021-pol2qm74 5771 17 - - HYPH cord-015021-pol2qm74 5771 18 related relate VBN cord-015021-pol2qm74 5771 19 prognostic prognostic JJ cord-015021-pol2qm74 5771 20 evaluation evaluation NN cord-015021-pol2qm74 5771 21 ( ( -LRB- cord-015021-pol2qm74 5771 22 0.99 0.99 CD cord-015021-pol2qm74 5771 23 ) ) -RRB- cord-015021-pol2qm74 5771 24 were be VBD cord-015021-pol2qm74 5771 25 significantly significantly RB cord-015021-pol2qm74 5771 26 ( ( -LRB- cord-015021-pol2qm74 5771 27 p<0,05 p<0,05 NNP cord-015021-pol2qm74 5771 28 ) ) -RRB- cord-015021-pol2qm74 5771 29 larger large JJR cord-015021-pol2qm74 5771 30 compared compare VBN cord-015021-pol2qm74 5771 31 to to IN cord-015021-pol2qm74 5771 32 SIRS SIRS NNP cord-015021-pol2qm74 5771 33 ( ( -LRB- cord-015021-pol2qm74 5771 34 0.79 0.79 CD cord-015021-pol2qm74 5771 35 and and CC cord-015021-pol2qm74 5771 36 0.86 0.86 CD cord-015021-pol2qm74 5771 37 , , , cord-015021-pol2qm74 5771 38 resp resp NNP cord-015021-pol2qm74 5771 39 . . NNP cord-015021-pol2qm74 5771 40 ) ) -RRB- cord-015021-pol2qm74 5771 41 , , , cord-015021-pol2qm74 5771 42 This this DT cord-015021-pol2qm74 5771 43 higher high JJR cord-015021-pol2qm74 5771 44 overall overall JJ cord-015021-pol2qm74 5771 45 accuracy accuracy NN cord-015021-pol2qm74 5771 46 of of IN cord-015021-pol2qm74 5771 47 the the DT cord-015021-pol2qm74 5771 48 Ele Ele NNP cord-015021-pol2qm74 5771 49 criterion criterion NN cord-015021-pol2qm74 5771 50 was be VBD cord-015021-pol2qm74 5771 51 primary primary JJ cord-015021-pol2qm74 5771 52 due due IN cord-015021-pol2qm74 5771 53 to to IN cord-015021-pol2qm74 5771 54 a a DT cord-015021-pol2qm74 5771 55 more more RBR cord-015021-pol2qm74 5771 56 valid valid JJ cord-015021-pol2qm74 5771 57 assessment assessment NN cord-015021-pol2qm74 5771 58 already already RB cord-015021-pol2qm74 5771 59 on on IN cord-015021-pol2qm74 5771 60 the the DT cord-015021-pol2qm74 5771 61 first first JJ cord-015021-pol2qm74 5771 62 and and CC cord-015021-pol2qm74 5771 63 second second JJ cord-015021-pol2qm74 5771 64 pop pop NN cord-015021-pol2qm74 5771 65 . . . cord-015021-pol2qm74 5772 1 day day NN cord-015021-pol2qm74 5772 2 , , , cord-015021-pol2qm74 5772 3 where where WRB cord-015021-pol2qm74 5772 4 SIRS SIRS NNP cord-015021-pol2qm74 5772 5 still still RB cord-015021-pol2qm74 5772 6 had have VBD cord-015021-pol2qm74 5772 7 a a DT cord-015021-pol2qm74 5772 8 high high JJ cord-015021-pol2qm74 5772 9 false false JJ cord-015021-pol2qm74 5772 10 positive positive JJ cord-015021-pol2qm74 5772 11 classification classification NN cord-015021-pol2qm74 5772 12 rate rate NN cord-015021-pol2qm74 5772 13 ( ( -LRB- cord-015021-pol2qm74 5772 14 46 46 CD cord-015021-pol2qm74 5772 15 % % NN cord-015021-pol2qm74 5772 16 and and CC cord-015021-pol2qm74 5772 17 53 53 CD cord-015021-pol2qm74 5772 18 % % NN cord-015021-pol2qm74 5772 19 , , , cord-015021-pol2qm74 5772 20 compared compare VBN cord-015021-pol2qm74 5772 21 to to IN cord-015021-pol2qm74 5772 22 7 7 CD cord-015021-pol2qm74 5772 23 % % NN cord-015021-pol2qm74 5772 24 and and CC cord-015021-pol2qm74 5772 25 1 1 CD cord-015021-pol2qm74 5772 26 % % NN cord-015021-pol2qm74 5772 27 , , , cord-015021-pol2qm74 5772 28 resp resp NNP cord-015021-pol2qm74 5772 29 . . . cord-015021-pol2qm74 5772 30 ) ) -RRB- cord-015021-pol2qm74 5772 31 . . . cord-015021-pol2qm74 5773 1 Conclusion conclusion NN cord-015021-pol2qm74 5773 2 : : : cord-015021-pol2qm74 5774 1 In in IN cord-015021-pol2qm74 5774 2 the the DT cord-015021-pol2qm74 5774 3 early early JJ cord-015021-pol2qm74 5774 4 postoperative postoperative JJ cord-015021-pol2qm74 5774 5 course course NN cord-015021-pol2qm74 5774 6 after after IN cord-015021-pol2qm74 5774 7 cardiac cardiac JJ cord-015021-pol2qm74 5774 8 surgery surgery NN cord-015021-pol2qm74 5774 9 , , , cord-015021-pol2qm74 5774 10 the the DT cord-015021-pol2qm74 5774 11 SIRS SIRS NNP cord-015021-pol2qm74 5774 12 definition definition NN cord-015021-pol2qm74 5774 13 displayed display VBD cord-015021-pol2qm74 5774 14 a a DT cord-015021-pol2qm74 5774 15 high high JJ cord-015021-pol2qm74 5774 16 false false JJ cord-015021-pol2qm74 5774 17 - - HYPH cord-015021-pol2qm74 5774 18 positive positive JJ cord-015021-pol2qm74 5774 19 classification classification NN cord-015021-pol2qm74 5774 20 rate rate NN cord-015021-pol2qm74 5774 21 ( ( -LRB- cord-015021-pol2qm74 5774 22 low low JJ cord-015021-pol2qm74 5774 23 specificity specificity NN cord-015021-pol2qm74 5774 24 ) ) -RRB- cord-015021-pol2qm74 5774 25 for for IN cord-015021-pol2qm74 5774 26 subsequent subsequent JJ cord-015021-pol2qm74 5774 27 sepsis sepsis NN cord-015021-pol2qm74 5774 28 - - HYPH cord-015021-pol2qm74 5774 29 related relate VBN cord-015021-pol2qm74 5774 30 mortality mortality NN cord-015021-pol2qm74 5774 31 compared compare VBN cord-015021-pol2qm74 5774 32 to to IN cord-015021-pol2qm74 5774 33 better well JJR cord-015021-pol2qm74 5774 34 classification classification NN cord-015021-pol2qm74 5774 35 results result NNS cord-015021-pol2qm74 5774 36 obtained obtain VBN cord-015021-pol2qm74 5774 37 by by IN cord-015021-pol2qm74 5774 38 the the DT cord-015021-pol2qm74 5774 39 Elebute Elebute NNP cord-015021-pol2qm74 5774 40 sepsis sepsis NN cord-015021-pol2qm74 5774 41 score score NN cord-015021-pol2qm74 5774 42 . . . cord-015021-pol2qm74 5775 1 From from IN cord-015021-pol2qm74 5775 2 the the DT cord-015021-pol2qm74 5775 3 Departments Departments NNPS cord-015021-pol2qm74 5775 4 of of IN cord-015021-pol2qm74 5775 5 Medicine Medicine NNP cord-015021-pol2qm74 5775 6 I I NNP cord-015021-pol2qm74 5775 7 and and CC cord-015021-pol2qm74 5775 8 of of IN cord-015021-pol2qm74 5775 9 " " `` cord-015021-pol2qm74 5775 10 Cardiac Cardiac NNP cord-015021-pol2qm74 5775 11 Surgery surgery NN cord-015021-pol2qm74 5775 12 , , , cord-015021-pol2qm74 5775 13 Grosshadern Grosshadern NNP cord-015021-pol2qm74 5775 14 University University NNP cord-015021-pol2qm74 5775 15 Hospital Hospital NNP cord-015021-pol2qm74 5775 16 , , , cord-015021-pol2qm74 5775 17 Marchioninistr Marchioninistr NNP cord-015021-pol2qm74 5775 18 . . . cord-015021-pol2qm74 5776 1 15 15 CD cord-015021-pol2qm74 5776 2 , , , cord-015021-pol2qm74 5776 3 D-81377 D-81377 NNS cord-015021-pol2qm74 5776 4 Munich Munich NNP cord-015021-pol2qm74 5776 5 , , , cord-015021-pol2qm74 5776 6 FRG FRG NNP cord-015021-pol2qm74 5776 7 . . . cord-015021-pol2qm74 5777 1 Correlation correlation NN cord-015021-pol2qm74 5777 2 between between IN cord-015021-pol2qm74 5777 3 physiological physiological JJ cord-015021-pol2qm74 5777 4 and and CC cord-015021-pol2qm74 5777 5 immunological immunological JJ cord-015021-pol2qm74 5777 6 parameters parameter NNS cord-015021-pol2qm74 5777 7 in in IN cord-015021-pol2qm74 5777 8 critically critically RB cord-015021-pol2qm74 5777 9 ill ill JJ cord-015021-pol2qm74 5777 10 septic septic JJ cord-015021-pol2qm74 5777 11 patients patient NNS cord-015021-pol2qm74 5777 12 . . . cord-015021-pol2qm74 5778 1 MA MA NNP cord-015021-pol2qm74 5778 2 Rogy Rogy NNP cord-015021-pol2qm74 5778 3 , , , cord-015021-pol2qm74 5778 4 H H NNP cord-015021-pol2qm74 5778 5 Oldenburg Oldenburg NNP cord-015021-pol2qm74 5778 6 , , , cord-015021-pol2qm74 5778 7 R R NNP cord-015021-pol2qm74 5778 8 Trousdale Trousdale NNP cord-015021-pol2qm74 5778 9 , , , cord-015021-pol2qm74 5778 10 S S NNP cord-015021-pol2qm74 5778 11 Coyle Coyle NNP cord-015021-pol2qm74 5778 12 , , , cord-015021-pol2qm74 5778 13 L L NNP cord-015021-pol2qm74 5778 14 Moldawer Moldawer NNP cord-015021-pol2qm74 5778 15 , , , cord-015021-pol2qm74 5778 16 SF SF NNP cord-015021-pol2qm74 5778 17 Lowry Lowry NNP cord-015021-pol2qm74 5778 18 A A NNP cord-015021-pol2qm74 5778 19 relationship relationship NN cord-015021-pol2qm74 5778 20 between between IN cord-015021-pol2qm74 5778 21 physiological physiological JJ cord-015021-pol2qm74 5778 22 parameters parameter NNS cord-015021-pol2qm74 5778 23 of of IN cord-015021-pol2qm74 5778 24 severe severe JJ cord-015021-pol2qm74 5778 25 sepsis sepsis NN cord-015021-pol2qm74 5778 26 and and CC cord-015021-pol2qm74 5778 27 immunological immunological JJ cord-015021-pol2qm74 5778 28 function function NN cord-015021-pol2qm74 5778 29 has have VBZ cord-015021-pol2qm74 5778 30 not not RB cord-015021-pol2qm74 5778 31 been be VBN cord-015021-pol2qm74 5778 32 established establish VBN cord-015021-pol2qm74 5778 33 . . . cord-015021-pol2qm74 5779 1 In in IN cord-015021-pol2qm74 5779 2 an an DT cord-015021-pol2qm74 5779 3 effort effort NN cord-015021-pol2qm74 5779 4 to to TO cord-015021-pol2qm74 5779 5 assess assess VB cord-015021-pol2qm74 5779 6 such such PDT cord-015021-pol2qm74 5779 7 a a DT cord-015021-pol2qm74 5779 8 relationship relationship NN cord-015021-pol2qm74 5779 9 we -PRON- PRP cord-015021-pol2qm74 5779 10 prospectively prospectively RB cord-015021-pol2qm74 5779 11 evaluated evaluate VBD cord-015021-pol2qm74 5779 12 nine nine CD cord-015021-pol2qm74 5779 13 severely severely RB cord-015021-pol2qm74 5779 14 ill ill JJ cord-015021-pol2qm74 5779 15 septic septic JJ cord-015021-pol2qm74 5779 16 patients patient NNS cord-015021-pol2qm74 5779 17 . . . cord-015021-pol2qm74 5780 1 Physiological physiological JJ cord-015021-pol2qm74 5780 2 risk risk NN cord-015021-pol2qm74 5780 3 was be VBD cord-015021-pol2qm74 5780 4 assessed assess VBN cord-015021-pol2qm74 5780 5 by by IN cord-015021-pol2qm74 5780 6 the the DT cord-015021-pol2qm74 5780 7 APACHE APACHE NNP cord-015021-pol2qm74 5780 8 III III NNP cord-015021-pol2qm74 5780 9 score score NN cord-015021-pol2qm74 5780 10 1 1 CD cord-015021-pol2qm74 5780 11 , , , cord-015021-pol2qm74 5780 12 while while IN cord-015021-pol2qm74 5780 13 one one CD cord-015021-pol2qm74 5780 14 component component NN cord-015021-pol2qm74 5780 15 of of IN cord-015021-pol2qm74 5780 16 immunologic immunologic JJ cord-015021-pol2qm74 5780 17 function function NN cord-015021-pol2qm74 5780 18 was be VBD cord-015021-pol2qm74 5780 19 evaluated evaluate VBN cord-015021-pol2qm74 5780 20 by by IN cord-015021-pol2qm74 5780 21 peripheral peripheral JJ cord-015021-pol2qm74 5780 22 blood blood NN cord-015021-pol2qm74 5780 23 mononuclear mononuclear NN cord-015021-pol2qm74 5780 24 cells cell NNS cord-015021-pol2qm74 5780 25 ( ( -LRB- cord-015021-pol2qm74 5780 26 PBMC PBMC NNP cord-015021-pol2qm74 5780 27 ) ) -RRB- cord-015021-pol2qm74 5780 28 eytokine eytokine NN cord-015021-pol2qm74 5780 29 production production NN cord-015021-pol2qm74 5780 30 after after IN cord-015021-pol2qm74 5780 31 in in IN cord-015021-pol2qm74 5780 32 vitro vitro FW cord-015021-pol2qm74 5780 33 LPS LPS NNP cord-015021-pol2qm74 5780 34 stimulation stimulation NN cord-015021-pol2qm74 5780 35 2 2 CD cord-015021-pol2qm74 5780 36 . . . cord-015021-pol2qm74 5781 1 Four four CD cord-015021-pol2qm74 5781 2 of of IN cord-015021-pol2qm74 5781 3 the the DT cord-015021-pol2qm74 5781 4 nine nine CD cord-015021-pol2qm74 5781 5 patients patient NNS cord-015021-pol2qm74 5781 6 died die VBD cord-015021-pol2qm74 5781 7 . . . cord-015021-pol2qm74 5782 1 APACHE APACHE NNP cord-015021-pol2qm74 5782 2 III iii CD cord-015021-pol2qm74 5782 3 scores score NNS cord-015021-pol2qm74 5782 4 at at IN cord-015021-pol2qm74 5782 5 72 72 CD cord-015021-pol2qm74 5782 6 h h NN cord-015021-pol2qm74 5782 7 were be VBD cord-015021-pol2qm74 5782 8 lower low JJR cord-015021-pol2qm74 5782 9 in in IN cord-015021-pol2qm74 5782 10 survivors survivor NNS cord-015021-pol2qm74 5782 11 ( ( -LRB- cord-015021-pol2qm74 5782 12 S S NNP cord-015021-pol2qm74 5782 13 ) ) -RRB- cord-015021-pol2qm74 5782 14 than than IN cord-015021-pol2qm74 5782 15 in in IN cord-015021-pol2qm74 5782 16 non non NNS cord-015021-pol2qm74 5782 17 - - NNS cord-015021-pol2qm74 5782 18 survivors survivor NNS cord-015021-pol2qm74 5782 19 ( ( -LRB- cord-015021-pol2qm74 5782 20 NS NS NNP cord-015021-pol2qm74 5782 21 ) ) -RRB- cord-015021-pol2qm74 5782 22 , , , cord-015021-pol2qm74 5782 23 ( ( -LRB- cord-015021-pol2qm74 5782 24 51-+13 51-+13 CD cord-015021-pol2qm74 5782 25 vs vs IN cord-015021-pol2qm74 5782 26 111-+1 111-+1 CD cord-015021-pol2qm74 5782 27 5 5 CD cord-015021-pol2qm74 5782 28 p<0.05 p<0.05 CD cord-015021-pol2qm74 5782 29 ) ) -RRB- cord-015021-pol2qm74 5782 30 , , , cord-015021-pol2qm74 5782 31 while while IN cord-015021-pol2qm74 5782 32 APACHE APACHE NNP cord-015021-pol2qm74 5782 33 III III NNP cord-015021-pol2qm74 5782 34 scores score NNS cord-015021-pol2qm74 5782 35 at at IN cord-015021-pol2qm74 5782 36 admission admission NN cord-015021-pol2qm74 5782 37 were be VBD cord-015021-pol2qm74 5782 38 not not RB cord-015021-pol2qm74 5782 39 significant significant JJ cord-015021-pol2qm74 5782 40 different different JJ cord-015021-pol2qm74 5782 41 between between IN cord-015021-pol2qm74 5782 42 S S NNP cord-015021-pol2qm74 5782 43 and and CC cord-015021-pol2qm74 5782 44 NS NS NNP cord-015021-pol2qm74 5782 45 ( ( -LRB- cord-015021-pol2qm74 5782 46 82-+13 82-+13 CD cord-015021-pol2qm74 5782 47 vs vs IN cord-015021-pol2qm74 5782 48 95-+13 95-+13 CD cord-015021-pol2qm74 5782 49 ) ) -RRB- cord-015021-pol2qm74 5782 50 . . . cord-015021-pol2qm74 5783 1 Down down IN cord-015021-pol2qm74 5783 2 regulation regulation NN cord-015021-pol2qm74 5783 3 of of IN cord-015021-pol2qm74 5783 4 cytokine cytokine NN cord-015021-pol2qm74 5783 5 production production NN cord-015021-pol2qm74 5783 6 by by IN cord-015021-pol2qm74 5783 7 PBMC PBMC NNP cord-015021-pol2qm74 5783 8 upon upon IN cord-015021-pol2qm74 5783 9 LPS LPS NNP cord-015021-pol2qm74 5783 10 stimulation stimulation NN cord-015021-pol2qm74 5783 11 was be VBD cord-015021-pol2qm74 5783 12 a a DT cord-015021-pol2qm74 5783 13 transient transient JJ cord-015021-pol2qm74 5783 14 event event NN cord-015021-pol2qm74 5783 15 in in IN cord-015021-pol2qm74 5783 16 S. S. NNP cord-015021-pol2qm74 5783 17 While while IN cord-015021-pol2qm74 5783 18 S S NNP cord-015021-pol2qm74 5783 19 demonstrated demonstrate VBD cord-015021-pol2qm74 5783 20 an an DT cord-015021-pol2qm74 5783 21 3 3 CD cord-015021-pol2qm74 5783 22 fold fold JJ cord-015021-pol2qm74 5783 23 increase increase NN cord-015021-pol2qm74 5783 24 of of IN cord-015021-pol2qm74 5783 25 TNF TNF NNP cord-015021-pol2qm74 5783 26 - - : cord-015021-pol2qm74 5783 27 a a DT cord-015021-pol2qm74 5783 28 bioactivity bioactivity NN cord-015021-pol2qm74 5784 1 with[r~ with[r~ NNP cord-015021-pol2qm74 5785 1 72 72 CD cord-015021-pol2qm74 5785 2 hours hour NNS cord-015021-pol2qm74 5785 3 , , , cord-015021-pol2qm74 5785 4 NS NS NNP cord-015021-pol2qm74 5785 5 did do VBD cord-015021-pol2qm74 5785 6 not not RB cord-015021-pol2qm74 5785 7 demonstrate demonstrate VB cord-015021-pol2qm74 5785 8 any any DT cord-015021-pol2qm74 5785 9 increase increase NN cord-015021-pol2qm74 5785 10 at at RB cord-015021-pol2qm74 5785 11 all all RB cord-015021-pol2qm74 5785 12 . . . cord-015021-pol2qm74 5786 1 A a DT cord-015021-pol2qm74 5786 2 similar similar JJ cord-015021-pol2qm74 5786 3 pattern pattern NN cord-015021-pol2qm74 5786 4 was be VBD cord-015021-pol2qm74 5786 5 demonstrated demonstrate VBN cord-015021-pol2qm74 5786 6 for for IN cord-015021-pol2qm74 5786 7 IL-1[3 il-1[3 JJ cord-015021-pol2qm74 5786 8 and and CC cord-015021-pol2qm74 5786 9 IL-6 IL-6 NNP cord-015021-pol2qm74 5786 10 immunoactivity immunoactivity NNP cord-015021-pol2qm74 5786 11 . . . cord-015021-pol2qm74 5787 1 TNF TNF NNP cord-015021-pol2qm74 5787 2 was be VBD cord-015021-pol2qm74 5787 3 measured measure VBN cord-015021-pol2qm74 5787 4 by by IN cord-015021-pol2qm74 5787 5 WEHI WEHI NNP cord-015021-pol2qm74 5787 6 bioactivity bioactivity NN cord-015021-pol2qm74 5787 7 , , , cord-015021-pol2qm74 5787 8 IL-1[~ IL-1[~ NNP cord-015021-pol2qm74 5787 9 and and CC cord-015021-pol2qm74 5787 10 IL-6 IL-6 NNP cord-015021-pol2qm74 5787 11 immunoactivity immunoactivity NNP cord-015021-pol2qm74 5787 12 were be VBD cord-015021-pol2qm74 5787 13 determined determine VBN cord-015021-pol2qm74 5787 14 by by IN cord-015021-pol2qm74 5787 15 ELISA ELISA NNP cord-015021-pol2qm74 5787 16 . . . cord-015021-pol2qm74 5788 1 The the DT cord-015021-pol2qm74 5788 2 sensitivity sensitivity NN cord-015021-pol2qm74 5788 3 was be VBD cord-015021-pol2qm74 5788 4 35 35 CD cord-015021-pol2qm74 5788 5 pg pg NN cord-015021-pol2qm74 5788 6 / / SYM cord-015021-pol2qm74 5788 7 ml ml NN cord-015021-pol2qm74 5788 8 for for IN cord-015021-pol2qm74 5788 9 TNF TNF NNP cord-015021-pol2qm74 5788 10 , , , cord-015021-pol2qm74 5788 11 30 30 CD cord-015021-pol2qm74 5788 12 pg pg NN cord-015021-pol2qm74 5788 13 / / SYM cord-015021-pol2qm74 5788 14 ml ml NN cord-015021-pol2qm74 5788 15 for for IN cord-015021-pol2qm74 5788 16 IL IL NNP cord-015021-pol2qm74 5788 17 - - HYPH cord-015021-pol2qm74 5788 18 ll3 ll3 NNS cord-015021-pol2qm74 5788 19 and and CC cord-015021-pol2qm74 5788 20 35 35 CD cord-015021-pol2qm74 5788 21 pg pg NN cord-015021-pol2qm74 5788 22 / / SYM cord-015021-pol2qm74 5788 23 ml ml NN cord-015021-pol2qm74 5788 24 for for IN cord-015021-pol2qm74 5788 25 IL-6 IL-6 NNP cord-015021-pol2qm74 5788 26 , , , cord-015021-pol2qm74 5788 27 respectively respectively RB cord-015021-pol2qm74 5788 28 . . . cord-015021-pol2qm74 5789 1 In in IN cord-015021-pol2qm74 5789 2 conclusion conclusion NN cord-015021-pol2qm74 5789 3 , , , cord-015021-pol2qm74 5789 4 both both DT cord-015021-pol2qm74 5789 5 physiological physiological JJ cord-015021-pol2qm74 5789 6 as as RB cord-015021-pol2qm74 5789 7 well well RB cord-015021-pol2qm74 5789 8 as as IN cord-015021-pol2qm74 5789 9 immunological immunological JJ cord-015021-pol2qm74 5789 10 functions function NNS cord-015021-pol2qm74 5789 11 of of IN cord-015021-pol2qm74 5789 12 severe severe JJ cord-015021-pol2qm74 5789 13 critically critically RB cord-015021-pol2qm74 5789 14 ill ill JJ cord-015021-pol2qm74 5789 15 septic septic JJ cord-015021-pol2qm74 5789 16 patients patient NNS cord-015021-pol2qm74 5789 17 demonstrate demonstrate VBP cord-015021-pol2qm74 5789 18 predictive predictive JJ cord-015021-pol2qm74 5789 19 value value NN cord-015021-pol2qm74 5789 20 for for IN cord-015021-pol2qm74 5789 21 ultimate ultimate JJ cord-015021-pol2qm74 5789 22 survival survival NN cord-015021-pol2qm74 5789 23 . . . cord-015021-pol2qm74 5790 1 While while IN cord-015021-pol2qm74 5790 2 patients patient NNS cord-015021-pol2qm74 5790 3 biological biological JJ cord-015021-pol2qm74 5790 4 status status NN cord-015021-pol2qm74 5790 5 seems seem VBZ cord-015021-pol2qm74 5790 6 to to TO cord-015021-pol2qm74 5790 7 be be VB cord-015021-pol2qm74 5790 8 more more RBR cord-015021-pol2qm74 5790 9 predictable predictable JJ cord-015021-pol2qm74 5790 10 by by IN cord-015021-pol2qm74 5790 11 APACHE APACHE NNP cord-015021-pol2qm74 5790 12 III III NNP cord-015021-pol2qm74 5790 13 at at IN cord-015021-pol2qm74 5790 14 day day NN cord-015021-pol2qm74 5790 15 3 3 CD cord-015021-pol2qm74 5790 16 , , , cord-015021-pol2qm74 5790 17 p<0.05 p<0.05 CD cord-015021-pol2qm74 5790 18 , , , cord-015021-pol2qm74 5790 19 the the DT cord-015021-pol2qm74 5790 20 pattern pattern NN cord-015021-pol2qm74 5790 21 of of IN cord-015021-pol2qm74 5790 22 cytokine cytokine NN cord-015021-pol2qm74 5790 23 production production NN cord-015021-pol2qm74 5790 24 by by IN cord-015021-pol2qm74 5790 25 PBMC PBMC NNP cord-015021-pol2qm74 5790 26 upon upon IN cord-015021-pol2qm74 5790 27 LPS LPS NNP cord-015021-pol2qm74 5790 28 stimulation stimulation NN cord-015021-pol2qm74 5790 29 over over IN cord-015021-pol2qm74 5790 30 the the DT cord-015021-pol2qm74 5790 31 first first JJ cord-015021-pol2qm74 5790 32 72h 72h NNS cord-015021-pol2qm74 5790 33 might may MD cord-015021-pol2qm74 5790 34 be be VB cord-015021-pol2qm74 5790 35 a a DT cord-015021-pol2qm74 5790 36 reliable reliable JJ cord-015021-pol2qm74 5790 37 predictor predictor NN cord-015021-pol2qm74 5790 38 as as RB cord-015021-pol2qm74 5790 39 well well RB cord-015021-pol2qm74 5790 40 . . . cord-015021-pol2qm74 5791 1 Introduction introduction NN cord-015021-pol2qm74 5791 2 : : : cord-015021-pol2qm74 5791 3 Therapy therapy NN cord-015021-pol2qm74 5791 4 of of IN cord-015021-pol2qm74 5791 5 sepsis sepsis NN cord-015021-pol2qm74 5791 6 and and CC cord-015021-pol2qm74 5791 7 its -PRON- PRP$ cord-015021-pol2qm74 5791 8 sequelae sequela NNS cord-015021-pol2qm74 5791 9 depends depend VBZ cord-015021-pol2qm74 5791 10 largely largely RB cord-015021-pol2qm74 5791 11 on on IN cord-015021-pol2qm74 5791 12 its -PRON- PRP$ cord-015021-pol2qm74 5791 13 early early JJ cord-015021-pol2qm74 5791 14 recognition recognition NN cord-015021-pol2qm74 5791 15 . . . cord-015021-pol2qm74 5792 1 Many many JJ cord-015021-pol2qm74 5792 2 studies study NNS cord-015021-pol2qm74 5792 3 have have VBP cord-015021-pol2qm74 5792 4 investigated investigate VBN cord-015021-pol2qm74 5792 5 the the DT cord-015021-pol2qm74 5792 6 change change NN cord-015021-pol2qm74 5792 7 of of IN cord-015021-pol2qm74 5792 8 certain certain JJ cord-015021-pol2qm74 5792 9 mediators mediator NNS cord-015021-pol2qm74 5792 10 during during IN cord-015021-pol2qm74 5792 11 sepsis sepsis NN cord-015021-pol2qm74 5792 12 and and CC cord-015021-pol2qm74 5792 13 their -PRON- PRP$ cord-015021-pol2qm74 5792 14 potential potential NN cord-015021-pol2qm74 5792 15 to to TO cord-015021-pol2qm74 5792 16 predict predict VB cord-015021-pol2qm74 5792 17 multiple multiple JJ cord-015021-pol2qm74 5792 18 organ organ NN cord-015021-pol2qm74 5792 19 failure failure NN cord-015021-pol2qm74 5792 20 and and CC cord-015021-pol2qm74 5792 21 outcome outcome NN cord-015021-pol2qm74 5792 22 . . . cord-015021-pol2qm74 5793 1 It -PRON- PRP cord-015021-pol2qm74 5793 2 was be VBD cord-015021-pol2qm74 5793 3 the the DT cord-015021-pol2qm74 5793 4 objective objective NN cord-015021-pol2qm74 5793 5 of of IN cord-015021-pol2qm74 5793 6 this this DT cord-015021-pol2qm74 5793 7 study study NN cord-015021-pol2qm74 5793 8 to to TO cord-015021-pol2qm74 5793 9 investigate investigate VB cord-015021-pol2qm74 5793 10 whether whether IN cord-015021-pol2qm74 5793 11 the the DT cord-015021-pol2qm74 5793 12 onset onset NN cord-015021-pol2qm74 5793 13 of of IN cord-015021-pol2qm74 5793 14 sepsis sepsis NN cord-015021-pol2qm74 5793 15 can can MD cord-015021-pol2qm74 5793 16 be be VB cord-015021-pol2qm74 5793 17 predicted predict VBN cord-015021-pol2qm74 5793 18 by by IN cord-015021-pol2qm74 5793 19 alterations alteration NNS cord-015021-pol2qm74 5793 20 of of IN cord-015021-pol2qm74 5793 21 levels level NNS cord-015021-pol2qm74 5793 22 of of IN cord-015021-pol2qm74 5793 23 interleukin-6 interleukin-6 NNP cord-015021-pol2qm74 5793 24 ( ( -LRB- cord-015021-pol2qm74 5793 25 IL-6 IL-6 NNP cord-015021-pol2qm74 5793 26 ) ) -RRB- cord-015021-pol2qm74 5793 27 , , , cord-015021-pol2qm74 5793 28 tumour tumour NN cord-015021-pol2qm74 5793 29 - - HYPH cord-015021-pol2qm74 5793 30 necrosis necrosis NN cord-015021-pol2qm74 5793 31 - - HYPH cord-015021-pol2qm74 5793 32 factor factor NN cord-015021-pol2qm74 5793 33 ( ( -LRB- cord-015021-pol2qm74 5793 34 TNF TNF NNP cord-015021-pol2qm74 5793 35 ) ) -RRB- cord-015021-pol2qm74 5793 36 , , , cord-015021-pol2qm74 5793 37 PMN pmn NN cord-015021-pol2qm74 5793 38 - - HYPH cord-015021-pol2qm74 5793 39 elastase elastase NN cord-015021-pol2qm74 5793 40 and and CC cord-015021-pol2qm74 5793 41 C c NN cord-015021-pol2qm74 5793 42 - - HYPH cord-015021-pol2qm74 5793 43 reactive reactive JJ cord-015021-pol2qm74 5793 44 protein protein NN cord-015021-pol2qm74 5793 45 ( ( -LRB- cord-015021-pol2qm74 5793 46 CRP CRP NNP cord-015021-pol2qm74 5793 47 ) ) -RRB- cord-015021-pol2qm74 5793 48 . . . cord-015021-pol2qm74 5794 1 Materials material NNS cord-015021-pol2qm74 5794 2 and and CC cord-015021-pol2qm74 5794 3 methods method NNS cord-015021-pol2qm74 5794 4 : : : cord-015021-pol2qm74 5794 5 Over over IN cord-015021-pol2qm74 5794 6 a a DT cord-015021-pol2qm74 5794 7 one one CD cord-015021-pol2qm74 5794 8 year year NN cord-015021-pol2qm74 5794 9 period period NN cord-015021-pol2qm74 5794 10 , , , cord-015021-pol2qm74 5794 11 40 40 CD cord-015021-pol2qm74 5794 12 polytraumatized polytraumatize VBN cord-015021-pol2qm74 5794 13 patients patient NNS cord-015021-pol2qm74 5794 14 were be VBD cord-015021-pol2qm74 5794 15 prospectively prospectively RB cord-015021-pol2qm74 5794 16 studied study VBN cord-015021-pol2qm74 5794 17 ( ( -LRB- cord-015021-pol2qm74 5794 18 mean mean VBP cord-015021-pol2qm74 5794 19 age age NN cord-015021-pol2qm74 5794 20 42y 42y CD cord-015021-pol2qm74 5794 21 , , , cord-015021-pol2qm74 5794 22 71 71 CD cord-015021-pol2qm74 5794 23 % % NN cord-015021-pol2qm74 5794 24 male male NN cord-015021-pol2qm74 5794 25 , , , cord-015021-pol2qm74 5794 26 ISS ISS NNP cord-015021-pol2qm74 5794 27 28 28 CD cord-015021-pol2qm74 5794 28 ) ) -RRB- cord-015021-pol2qm74 5794 29 . . . cord-015021-pol2qm74 5795 1 Serum serum NN cord-015021-pol2qm74 5795 2 and and CC cord-015021-pol2qm74 5795 3 EDTA edta NN cord-015021-pol2qm74 5795 4 - - HYPH cord-015021-pol2qm74 5795 5 plasma plasma NN cord-015021-pol2qm74 5795 6 samples sample NNS cord-015021-pol2qm74 5795 7 were be VBD cord-015021-pol2qm74 5795 8 taken take VBN cord-015021-pol2qm74 5795 9 in in RP cord-015021-pol2qm74 5795 10 12h 12h CD cord-015021-pol2qm74 5795 11 intervalls intervall NNS cord-015021-pol2qm74 5795 12 until until IN cord-015021-pol2qm74 5795 13 the the DT cord-015021-pol2qm74 5795 14 patient patient NN cord-015021-pol2qm74 5795 15 left leave VBD cord-015021-pol2qm74 5795 16 the the DT cord-015021-pol2qm74 5795 17 ICU ICU NNP cord-015021-pol2qm74 5795 18 . . . cord-015021-pol2qm74 5796 1 IL-6 IL-6 NNP cord-015021-pol2qm74 5796 2 , , , cord-015021-pol2qm74 5796 3 TNF TNF NNP cord-015021-pol2qm74 5796 4 , , , cord-015021-pol2qm74 5796 5 elastase elastase NN cord-015021-pol2qm74 5796 6 , , , cord-015021-pol2qm74 5796 7 and and CC cord-015021-pol2qm74 5796 8 CRP CRP NNP cord-015021-pol2qm74 5796 9 were be VBD cord-015021-pol2qm74 5796 10 determined determine VBN cord-015021-pol2qm74 5796 11 immunologically immunologically RB cord-015021-pol2qm74 5796 12 . . . cord-015021-pol2qm74 5797 1 Sepsis sepsis NN cord-015021-pol2qm74 5797 2 was be VBD cord-015021-pol2qm74 5797 3 defined define VBN cord-015021-pol2qm74 5797 4 according accord VBG cord-015021-pol2qm74 5797 5 to to IN cord-015021-pol2qm74 5797 6 the the DT cord-015021-pol2qm74 5797 7 criteria criterion NNS cord-015021-pol2qm74 5797 8 of of IN cord-015021-pol2qm74 5797 9 ' ' `` cord-015021-pol2qm74 5797 10 systemic systemic JJ cord-015021-pol2qm74 5797 11 sepsis sepsis NN cord-015021-pol2qm74 5797 12 ' ' '' cord-015021-pol2qm74 5797 13 ( ( -LRB- cord-015021-pol2qm74 5797 14 Veterans Veterans NNPS cord-015021-pol2qm74 5797 15 " " '' cord-015021-pol2qm74 5797 16 Administration Administration NNP cord-015021-pol2qm74 5797 17 Study Study NNP cord-015021-pol2qm74 5797 18 , , , cord-015021-pol2qm74 5797 19 1987 1987 CD cord-015021-pol2qm74 5797 20 ) ) -RRB- cord-015021-pol2qm74 5797 21 with with IN cord-015021-pol2qm74 5797 22 at at RB cord-015021-pol2qm74 5797 23 least least JJS cord-015021-pol2qm74 5797 24 4 4 CD cord-015021-pol2qm74 5797 25 of of IN cord-015021-pol2qm74 5797 26 7 7 CD cord-015021-pol2qm74 5797 27 clinical clinical JJ cord-015021-pol2qm74 5797 28 signs sign NNS cord-015021-pol2qm74 5797 29 : : : cord-015021-pol2qm74 5797 30 ( ( -LRB- cord-015021-pol2qm74 5797 31 1 1 LS cord-015021-pol2qm74 5797 32 ) ) -RRB- cord-015021-pol2qm74 5797 33 tachycar tachycar JJ cord-015021-pol2qm74 5797 34 - - HYPH cord-015021-pol2qm74 5797 35 dia dia NNP cord-015021-pol2qm74 5797 36 > > XX cord-015021-pol2qm74 5797 37 100 100 CD cord-015021-pol2qm74 5797 38 / / SYM cord-015021-pol2qm74 5797 39 min min NN cord-015021-pol2qm74 5797 40 , , , cord-015021-pol2qm74 5797 41 ( ( -LRB- cord-015021-pol2qm74 5797 42 2 2 LS cord-015021-pol2qm74 5797 43 ) ) -RRB- cord-015021-pol2qm74 5797 44 temperature temperature NN cord-015021-pol2qm74 5797 45 > > XX cord-015021-pol2qm74 5798 1 38,9 38,9 CD cord-015021-pol2qm74 5798 2 ° ° NNP cord-015021-pol2qm74 5798 3 C C NNP cord-015021-pol2qm74 5798 4 , , , cord-015021-pol2qm74 5798 5 ( ( -LRB- cord-015021-pol2qm74 5798 6 3 3 LS cord-015021-pol2qm74 5798 7 ) ) -RRB- cord-015021-pol2qm74 5798 8 blood blood NN cord-015021-pol2qm74 5798 9 pressure pressure NN cord-015021-pol2qm74 5798 10 < < XX cord-015021-pol2qm74 5798 11 100mmHg 100mmhg CD cord-015021-pol2qm74 5798 12 , , , cord-015021-pol2qm74 5798 13 ( ( -LRB- cord-015021-pol2qm74 5798 14 4 4 LS cord-015021-pol2qm74 5798 15 ) ) -RRB- cord-015021-pol2qm74 5798 16 mechanical mechanical JJ cord-015021-pol2qm74 5798 17 ventilation ventilation NN cord-015021-pol2qm74 5798 18 , , , cord-015021-pol2qm74 5799 1 ( ( -LRB- cord-015021-pol2qm74 5799 2 5 5 LS cord-015021-pol2qm74 5799 3 ) ) -RRB- cord-015021-pol2qm74 5799 4 leukocytosis leukocytosis NN cord-015021-pol2qm74 5799 5 > > XX cord-015021-pol2qm74 5800 1 15.000 15.000 CD cord-015021-pol2qm74 5800 2 /ml /ml NFP cord-015021-pol2qm74 5800 3 , , , cord-015021-pol2qm74 5800 4 ( ( -LRB- cord-015021-pol2qm74 5800 5 6 6 LS cord-015021-pol2qm74 5800 6 ) ) -RRB- cord-015021-pol2qm74 5800 7 thrombocytopenia thrombocytopenia NN cord-015021-pol2qm74 5801 1 < < XX cord-015021-pol2qm74 5802 1 100.000 100.000 CD cord-015021-pol2qm74 5802 2 / / SYM cord-015021-pol2qm74 5802 3 ml ml NN cord-015021-pol2qm74 5802 4 and and CC cord-015021-pol2qm74 5802 5 ( ( -LRB- cord-015021-pol2qm74 5802 6 7 7 LS cord-015021-pol2qm74 5802 7 ) ) -RRB- cord-015021-pol2qm74 5802 8 presence presence NN cord-015021-pol2qm74 5802 9 of of IN cord-015021-pol2qm74 5802 10 an an DT cord-015021-pol2qm74 5802 11 obvious obvious JJ cord-015021-pol2qm74 5802 12 septic septic JJ cord-015021-pol2qm74 5802 13 focus focus NN cord-015021-pol2qm74 5802 14 . . . cord-015021-pol2qm74 5803 1 Clinical clinical JJ cord-015021-pol2qm74 5803 2 parameters parameter NNS cord-015021-pol2qm74 5803 3 , , , cord-015021-pol2qm74 5803 4 sepsis sepsis NN cord-015021-pol2qm74 5803 5 severity severity NN cord-015021-pol2qm74 5803 6 and and CC cord-015021-pol2qm74 5803 7 serum serum NN cord-015021-pol2qm74 5803 8 levels level NNS cord-015021-pol2qm74 5803 9 were be VBD cord-015021-pol2qm74 5803 10 documented document VBN cord-015021-pol2qm74 5803 11 on on IN cord-015021-pol2qm74 5803 12 a a DT cord-015021-pol2qm74 5803 13 daily daily JJ cord-015021-pol2qm74 5803 14 basis basis NN cord-015021-pol2qm74 5803 15 , , , cord-015021-pol2qm74 5803 16 beginning begin VBG cord-015021-pol2qm74 5803 17 on on IN cord-015021-pol2qm74 5803 18 day day NN cord-015021-pol2qm74 5803 19 2 2 CD cord-015021-pol2qm74 5803 20 after after IN cord-015021-pol2qm74 5803 21 trauma trauma NN cord-015021-pol2qm74 5803 22 . . . cord-015021-pol2qm74 5804 1 Results result NNS cord-015021-pol2qm74 5804 2 : : : cord-015021-pol2qm74 5804 3 21 21 CD cord-015021-pol2qm74 5804 4 of of IN cord-015021-pol2qm74 5804 5 40 40 CD cord-015021-pol2qm74 5804 6 patients patient NNS cord-015021-pol2qm74 5804 7 developed develop VBD cord-015021-pol2qm74 5804 8 a a DT cord-015021-pol2qm74 5804 9 systemic systemic JJ cord-015021-pol2qm74 5804 10 sepsis sepsis NN cord-015021-pol2qm74 5804 11 ( ( -LRB- cord-015021-pol2qm74 5804 12 52.5 52.5 CD cord-015021-pol2qm74 5804 13 % % NN cord-015021-pol2qm74 5804 14 ) ) -RRB- cord-015021-pol2qm74 5804 15 , , , cord-015021-pol2qm74 5804 16 and and CC cord-015021-pol2qm74 5804 17 5 5 CD cord-015021-pol2qm74 5804 18 died die VBD cord-015021-pol2qm74 5804 19 . . . cord-015021-pol2qm74 5805 1 All all DT cord-015021-pol2qm74 5805 2 mediator mediator NN cord-015021-pol2qm74 5805 3 levels level NNS cord-015021-pol2qm74 5805 4 were be VBD cord-015021-pol2qm74 5805 5 elevated elevate VBN cord-015021-pol2qm74 5805 6 under under IN cord-015021-pol2qm74 5805 7 septic septic JJ cord-015021-pol2qm74 5805 8 conditions condition NNS cord-015021-pol2qm74 5805 9 . . . cord-015021-pol2qm74 5806 1 The the DT cord-015021-pol2qm74 5806 2 clinical clinical JJ cord-015021-pol2qm74 5806 3 severity severity NN cord-015021-pol2qm74 5806 4 of of IN cord-015021-pol2qm74 5806 5 sepsis sepsis NN cord-015021-pol2qm74 5806 6 correlated correlate VBN cord-015021-pol2qm74 5806 7 well well RB cord-015021-pol2qm74 5806 8 with with IN cord-015021-pol2qm74 5806 9 the the DT cord-015021-pol2qm74 5806 10 respective respective JJ cord-015021-pol2qm74 5806 11 levels level NNS cord-015021-pol2qm74 5806 12 of of IN cord-015021-pol2qm74 5806 13 mediators mediator NNS cord-015021-pol2qm74 5806 14 . . . cord-015021-pol2qm74 5807 1 In in IN cord-015021-pol2qm74 5807 2 patients patient NNS cord-015021-pol2qm74 5807 3 , , , cord-015021-pol2qm74 5807 4 who who WP cord-015021-pol2qm74 5807 5 developed develop VBD cord-015021-pol2qm74 5807 6 a a DT cord-015021-pol2qm74 5807 7 sepsis sepsis NN cord-015021-pol2qm74 5807 8 the the DT cord-015021-pol2qm74 5807 9 following follow VBG cord-015021-pol2qm74 5807 10 day day NN cord-015021-pol2qm74 5807 11 , , , cord-015021-pol2qm74 5807 12 IL-6 IL-6 NNP cord-015021-pol2qm74 5807 13 ( ( -LRB- cord-015021-pol2qm74 5807 14 510 510 CD cord-015021-pol2qm74 5807 15 vs. vs. IN cord-015021-pol2qm74 5807 16 195 195 CD cord-015021-pol2qm74 5807 17 ng ng NN cord-015021-pol2qm74 5807 18 / / SYM cord-015021-pol2qm74 5807 19 l l NN cord-015021-pol2qm74 5807 20 ; ; : cord-015021-pol2qm74 5807 21 p=0.029 p=0.029 NNP cord-015021-pol2qm74 5807 22 ) ) -RRB- cord-015021-pol2qm74 5807 23 , , , cord-015021-pol2qm74 5807 24 CRP CRP NNP cord-015021-pol2qm74 5807 25 ( ( -LRB- cord-015021-pol2qm74 5807 26 160 160 CD cord-015021-pol2qm74 5807 27 vs. vs. NN cord-015021-pol2qm74 5807 28 121 121 CD cord-015021-pol2qm74 5807 29 mg mg NNP cord-015021-pol2qm74 5807 30 / / SYM cord-015021-pol2qm74 5807 31 l l NN cord-015021-pol2qm74 5807 32 ; ; : cord-015021-pol2qm74 5807 33 p=0.035 p=0.035 NNP cord-015021-pol2qm74 5807 34 ) ) -RRB- cord-015021-pol2qm74 5807 35 and and CC cord-015021-pol2qm74 5807 36 TNF TNF NNP cord-015021-pol2qm74 5807 37 ( ( -LRB- cord-015021-pol2qm74 5807 38 32 32 CD cord-015021-pol2qm74 5807 39 vs. vs. NN cord-015021-pol2qm74 5807 40 15 15 CD cord-015021-pol2qm74 5807 41 ng ng NNP cord-015021-pol2qm74 5807 42 / / SYM cord-015021-pol2qm74 5807 43 l l NN cord-015021-pol2qm74 5807 44 ; ; : cord-015021-pol2qm74 5807 45 p=0.045 p=0.045 NNP cord-015021-pol2qm74 5807 46 ) ) -RRB- cord-015021-pol2qm74 5807 47 were be VBD cord-015021-pol2qm74 5807 48 significantly significantly RB cord-015021-pol2qm74 5807 49 increased increase VBN cord-015021-pol2qm74 5807 50 as as IN cord-015021-pol2qm74 5807 51 compared compare VBN cord-015021-pol2qm74 5807 52 to to IN cord-015021-pol2qm74 5807 53 those those DT cord-015021-pol2qm74 5807 54 patients patient NNS cord-015021-pol2qm74 5807 55 who who WP cord-015021-pol2qm74 5807 56 remained remain VBD cord-015021-pol2qm74 5807 57 non non JJ cord-015021-pol2qm74 5807 58 - - JJ cord-015021-pol2qm74 5807 59 septic septic JJ cord-015021-pol2qm74 5807 60 . . . cord-015021-pol2qm74 5808 1 Elastase Elastase NNP cord-015021-pol2qm74 5808 2 levels level NNS cord-015021-pol2qm74 5808 3 were be VBD cord-015021-pol2qm74 5808 4 considerably considerably RB cord-015021-pol2qm74 5808 5 elevated elevated JJ cord-015021-pol2qm74 5808 6 but but CC cord-015021-pol2qm74 5808 7 did do VBD cord-015021-pol2qm74 5808 8 not not RB cord-015021-pol2qm74 5808 9 reach reach VB cord-015021-pol2qm74 5808 10 the the DT cord-015021-pol2qm74 5808 11 level level NN cord-015021-pol2qm74 5808 12 of of IN cord-015021-pol2qm74 5808 13 significance significance NN cord-015021-pol2qm74 5808 14 . . . cord-015021-pol2qm74 5809 1 We -PRON- PRP cord-015021-pol2qm74 5809 2 conclude conclude VBP cord-015021-pol2qm74 5809 3 that that IN cord-015021-pol2qm74 5809 4 IL-6 IL-6 NNP cord-015021-pol2qm74 5809 5 , , , cord-015021-pol2qm74 5809 6 TNF TNF NNP cord-015021-pol2qm74 5809 7 and and CC cord-015021-pol2qm74 5809 8 CRP CRP NNP cord-015021-pol2qm74 5809 9 appear appear VBP cord-015021-pol2qm74 5809 10 to to TO cord-015021-pol2qm74 5809 11 be be VB cord-015021-pol2qm74 5809 12 sensitive sensitive JJ cord-015021-pol2qm74 5809 13 markers marker NNS cord-015021-pol2qm74 5809 14 for for IN cord-015021-pol2qm74 5809 15 prediction prediction NN cord-015021-pol2qm74 5809 16 of of IN cord-015021-pol2qm74 5809 17 septic septic JJ cord-015021-pol2qm74 5809 18 complications complication NNS cord-015021-pol2qm74 5809 19 in in IN cord-015021-pol2qm74 5809 20 polytraumatized polytraumatize VBN cord-015021-pol2qm74 5809 21 patients patient NNS cord-015021-pol2qm74 5809 22 . . . cord-015021-pol2qm74 5810 1 Objectives objective NNS cord-015021-pol2qm74 5810 2 of of IN cord-015021-pol2qm74 5810 3 the the DT cord-015021-pol2qm74 5810 4 study study NN cord-015021-pol2qm74 5810 5 : : : cord-015021-pol2qm74 5810 6 The the DT cord-015021-pol2qm74 5810 7 assessment assessment NN cord-015021-pol2qm74 5810 8 of of IN cord-015021-pol2qm74 5810 9 liver liver NN cord-015021-pol2qm74 5810 10 function function NN cord-015021-pol2qm74 5810 11 in in IN cord-015021-pol2qm74 5810 12 polytraumatized polytraumatize VBN cord-015021-pol2qm74 5810 13 patients patient NNS cord-015021-pol2qm74 5810 14 who who WP cord-015021-pol2qm74 5810 15 are be VBP cord-015021-pol2qm74 5810 16 at at IN cord-015021-pol2qm74 5810 17 risk risk NN cord-015021-pol2qm74 5810 18 of of IN cord-015021-pol2qm74 5810 19 developing develop VBG cord-015021-pol2qm74 5810 20 MOF MOF NNP cord-015021-pol2qm74 5810 21 is be VBZ cord-015021-pol2qm74 5810 22 too too RB cord-015021-pol2qm74 5810 23 inaccurate inaccurate JJ cord-015021-pol2qm74 5810 24 and and CC cord-015021-pol2qm74 5810 25 late late RB cord-015021-pol2qm74 5810 26 by by IN cord-015021-pol2qm74 5810 27 using use VBG cord-015021-pol2qm74 5810 28 conventional conventional JJ cord-015021-pol2qm74 5810 29 biochemical biochemical JJ cord-015021-pol2qm74 5810 30 parameters parameter NNS cord-015021-pol2qm74 5810 31 . . . cord-015021-pol2qm74 5811 1 Methats Methats NNP cord-015021-pol2qm74 5811 2 : : : cord-015021-pol2qm74 5812 1 The the DT cord-015021-pol2qm74 5812 2 injury injury NN cord-015021-pol2qm74 5812 3 severity severity NN cord-015021-pol2qm74 5812 4 of of IN cord-015021-pol2qm74 5812 5 the the DT cord-015021-pol2qm74 5812 6 patients patient NNS cord-015021-pol2qm74 5812 7 ( ( -LRB- cord-015021-pol2qm74 5812 8 n=26 n=26 RB cord-015021-pol2qm74 5812 9 ) ) -RRB- cord-015021-pol2qm74 5812 10 was be VBD cord-015021-pol2qm74 5812 11 determined determine VBN cord-015021-pol2qm74 5812 12 by by IN cord-015021-pol2qm74 5812 13 the the DT cord-015021-pol2qm74 5812 14 Injury Injury NNP cord-015021-pol2qm74 5812 15 Severity Severity NNP cord-015021-pol2qm74 5812 16 Score Score NNP cord-015021-pol2qm74 5812 17 ( ( -LRB- cord-015021-pol2qm74 5812 18 ISS ISS NNP cord-015021-pol2qm74 5812 19 ) ) -RRB- cord-015021-pol2qm74 5812 20 . . . cord-015021-pol2qm74 5813 1 Lidocaine lidocaine NN cord-015021-pol2qm74 5813 2 is be VBZ cord-015021-pol2qm74 5813 3 given give VBN cord-015021-pol2qm74 5813 4 at at IN cord-015021-pol2qm74 5813 5 a a DT cord-015021-pol2qm74 5813 6 dose dose NN cord-015021-pol2qm74 5813 7 of of IN cord-015021-pol2qm74 5813 8 1 1 CD cord-015021-pol2qm74 5813 9 mg mg NNP cord-015021-pol2qm74 5813 10 / / SYM cord-015021-pol2qm74 5813 11 kgBW kgBW NNP cord-015021-pol2qm74 5813 12 over over IN cord-015021-pol2qm74 5813 13 2 2 CD cord-015021-pol2qm74 5813 14 rain rain NN cord-015021-pol2qm74 5813 15 . . . cord-015021-pol2qm74 5814 1 i.v i.v NNP cord-015021-pol2qm74 5814 2 . . . cord-015021-pol2qm74 5815 1 and and CC cord-015021-pol2qm74 5815 2 is be VBZ cord-015021-pol2qm74 5815 3 metabolized metabolize VBN cord-015021-pol2qm74 5815 4 in in IN cord-015021-pol2qm74 5815 5 the the DT cord-015021-pol2qm74 5815 6 liver liver NN cord-015021-pol2qm74 5815 7 by by IN cord-015021-pol2qm74 5815 8 a a DT cord-015021-pol2qm74 5815 9 cytochrome cytochrome NN cord-015021-pol2qm74 5815 10 P-450 p-450 NN cord-015021-pol2qm74 5815 11 mechanism mechanism NN cord-015021-pol2qm74 5815 12 to to IN cord-015021-pol2qm74 5815 13 monoethylglycinexylidide monoethylglycinexylidide NN cord-015021-pol2qm74 5815 14 ( ( -LRB- cord-015021-pol2qm74 5815 15 MEGX MEGX NNP cord-015021-pol2qm74 5815 16 ) ) -RRB- cord-015021-pol2qm74 5815 17 . . . cord-015021-pol2qm74 5816 1 The the DT cord-015021-pol2qm74 5816 2 metabolite metabolite NN cord-015021-pol2qm74 5816 3 is be VBZ cord-015021-pol2qm74 5816 4 measured measure VBN cord-015021-pol2qm74 5816 5 by by IN cord-015021-pol2qm74 5816 6 a a DT cord-015021-pol2qm74 5816 7 fluorescence fluorescence NN cord-015021-pol2qm74 5816 8 polarization polarization NN cord-015021-pol2qm74 5816 9 immunoassay immunoassay JJ cord-015021-pol2qm74 5816 10 . . . cord-015021-pol2qm74 5817 1 Serial serial JJ cord-015021-pol2qm74 5817 2 determinations determination NNS cord-015021-pol2qm74 5817 3 of of IN cord-015021-pol2qm74 5817 4 the the DT cord-015021-pol2qm74 5817 5 test test NN cord-015021-pol2qm74 5817 6 were be VBD cord-015021-pol2qm74 5817 7 performed perform VBN cord-015021-pol2qm74 5817 8 between between IN cord-015021-pol2qm74 5817 9 the the DT cord-015021-pol2qm74 5817 10 1 1 CD cord-015021-pol2qm74 5817 11 ~t ~t NNPS cord-015021-pol2qm74 5817 12 and and CC cord-015021-pol2qm74 5817 13 the the DT cord-015021-pol2qm74 5817 14 11 11 CD cord-015021-pol2qm74 5817 15 ~ ~ CD cord-015021-pol2qm74 5817 16 day day NN cord-015021-pol2qm74 5817 17 after after IN cord-015021-pol2qm74 5817 18 trauma trauma NN cord-015021-pol2qm74 5817 19 and and CC cord-015021-pol2qm74 5817 20 were be VBD cord-015021-pol2qm74 5817 21 compared compare VBN cord-015021-pol2qm74 5817 22 with with IN cord-015021-pol2qm74 5817 23 other other JJ cord-015021-pol2qm74 5817 24 liver liver NN cord-015021-pol2qm74 5817 25 function function NN cord-015021-pol2qm74 5817 26 tests test NNS cord-015021-pol2qm74 5817 27 ( ( -LRB- cord-015021-pol2qm74 5817 28 bilimbin bilimbin NNP cord-015021-pol2qm74 5817 29 , , , cord-015021-pol2qm74 5817 30 GLDH GLDH NNP cord-015021-pol2qm74 5817 31 , , , cord-015021-pol2qm74 5817 32 ALT ALT NNP cord-015021-pol2qm74 5817 33 , , , cord-015021-pol2qm74 5817 34 AST AST NNP cord-015021-pol2qm74 5817 35 ) ) -RRB- cord-015021-pol2qm74 5817 36 . . . cord-015021-pol2qm74 5818 1 The the DT cord-015021-pol2qm74 5818 2 systemic systemic JJ cord-015021-pol2qm74 5818 3 inflammatory inflammatory JJ cord-015021-pol2qm74 5818 4 response response NN cord-015021-pol2qm74 5818 5 syndrome syndrome NN cord-015021-pol2qm74 5818 6 ( ( -LRB- cord-015021-pol2qm74 5818 7 SIRS SIRS NNP cord-015021-pol2qm74 5818 8 ) ) -RRB- cord-015021-pol2qm74 5818 9 is be VBZ cord-015021-pol2qm74 5818 10 still still RB cord-015021-pol2qm74 5818 11 a a DT cord-015021-pol2qm74 5818 12 challenge challenge NN cord-015021-pol2qm74 5818 13 concerning concern VBG cord-015021-pol2qm74 5818 14 early early JJ cord-015021-pol2qm74 5818 15 diagnosis diagnosis NN cord-015021-pol2qm74 5818 16 , , , cord-015021-pol2qm74 5818 17 therapy therapy NN cord-015021-pol2qm74 5818 18 and and CC cord-015021-pol2qm74 5818 19 prognosis prognosis NN cord-015021-pol2qm74 5818 20 . . . cord-015021-pol2qm74 5819 1 Therefore therefore RB cord-015021-pol2qm74 5819 2 , , , cord-015021-pol2qm74 5819 3 evaluation evaluation NN cord-015021-pol2qm74 5819 4 of of IN cord-015021-pol2qm74 5819 5 inflammatory inflammatory JJ cord-015021-pol2qm74 5819 6 and and CC cord-015021-pol2qm74 5819 7 disease disease NN cord-015021-pol2qm74 5819 8 activity activity NN cord-015021-pol2qm74 5819 9 becomes become VBZ cord-015021-pol2qm74 5819 10 more more RBR cord-015021-pol2qm74 5819 11 important important JJ cord-015021-pol2qm74 5819 12 . . . cord-015021-pol2qm74 5820 1 C C NNP cord-015021-pol2qm74 5820 2 - - HYPH cord-015021-pol2qm74 5820 3 reactive reactive JJ cord-015021-pol2qm74 5820 4 protein protein NN cord-015021-pol2qm74 5820 5 ( ( -LRB- cord-015021-pol2qm74 5820 6 CRP CRP NNP cord-015021-pol2qm74 5820 7 ) ) -RRB- cord-015021-pol2qm74 5820 8 is be VBZ cord-015021-pol2qm74 5820 9 a a DT cord-015021-pol2qm74 5820 10 well well RB cord-015021-pol2qm74 5820 11 established establish VBN cord-015021-pol2qm74 5820 12 acute acute JJ cord-015021-pol2qm74 5820 13 phase phase NN cord-015021-pol2qm74 5820 14 protein protein NN cord-015021-pol2qm74 5820 15 in in IN cord-015021-pol2qm74 5820 16 chronic chronic JJ cord-015021-pol2qm74 5820 17 inflammatory inflammatory JJ cord-015021-pol2qm74 5820 18 diseases disease NNS cord-015021-pol2qm74 5820 19 . . . cord-015021-pol2qm74 5821 1 Recent recent JJ cord-015021-pol2qm74 5821 2 reports report NNS cord-015021-pol2qm74 5821 3 suggest suggest VBP cord-015021-pol2qm74 5821 4 an an DT cord-015021-pol2qm74 5821 5 induction induction NN cord-015021-pol2qm74 5821 6 of of IN cord-015021-pol2qm74 5821 7 CRP CRP NNP cord-015021-pol2qm74 5821 8 by by IN cord-015021-pol2qm74 5821 9 interteukin-6 interteukin-6 NNP cord-015021-pol2qm74 5821 10 ( ( -LRB- cord-015021-pol2qm74 5821 11 IL-6 IL-6 NNP cord-015021-pol2qm74 5821 12 ) ) -RRB- cord-015021-pol2qm74 5821 13 , , , cord-015021-pol2qm74 5821 14 a a DT cord-015021-pol2qm74 5821 15 cytokine cytokine NN cord-015021-pol2qm74 5821 16 involved involve VBN cord-015021-pol2qm74 5821 17 in in IN cord-015021-pol2qm74 5821 18 the the DT cord-015021-pol2qm74 5821 19 mediator mediator NN cord-015021-pol2qm74 5821 20 cascade cascade NN cord-015021-pol2qm74 5821 21 of of IN cord-015021-pol2qm74 5821 22 SIRS SIRS NNP cord-015021-pol2qm74 5821 23 . . . cord-015021-pol2qm74 5822 1 On on IN cord-015021-pol2qm74 5822 2 the the DT cord-015021-pol2qm74 5822 3 other other JJ cord-015021-pol2qm74 5822 4 hand hand NN cord-015021-pol2qm74 5822 5 , , , cord-015021-pol2qm74 5822 6 tumornecmsisfactor tumornecmsisfactor NNP cord-015021-pol2qm74 5822 7 alpha alpha NN cord-015021-pol2qm74 5822 8 ( ( -LRB- cord-015021-pol2qm74 5822 9 TNFcx TNFcx NNP cord-015021-pol2qm74 5822 10 ) ) -RRB- cord-015021-pol2qm74 5822 11 is be VBZ cord-015021-pol2qm74 5822 12 a a DT cord-015021-pol2qm74 5822 13 very very RB cord-015021-pol2qm74 5822 14 early early RB cord-015021-pol2qm74 5822 15 released release VBN cord-015021-pol2qm74 5822 16 mediator mediator NN cord-015021-pol2qm74 5822 17 in in IN cord-015021-pol2qm74 5822 18 SIRS SIRS NNP cord-015021-pol2qm74 5822 19 removed remove VBD cord-015021-pol2qm74 5822 20 very very RB cord-015021-pol2qm74 5822 21 rapidly rapidly RB cord-015021-pol2qm74 5822 22 from from IN cord-015021-pol2qm74 5822 23 circulation circulation NN cord-015021-pol2qm74 5822 24 . . . cord-015021-pol2qm74 5823 1 In in IN cord-015021-pol2qm74 5823 2 addition addition NN cord-015021-pol2qm74 5823 3 , , , cord-015021-pol2qm74 5823 4 soluble soluble JJ cord-015021-pol2qm74 5823 5 TNF TNF NNP cord-015021-pol2qm74 5823 6 receptors receptor NNS cord-015021-pol2qm74 5823 7 ( ( -LRB- cord-015021-pol2qm74 5823 8 sTNFR~5 sTNFR~5 NNP cord-015021-pol2qm74 5823 9 , , , cord-015021-pol2qm74 5823 10 sTNFR75 sTNFR75 NNS cord-015021-pol2qm74 5823 11 ) ) -RRB- cord-015021-pol2qm74 5823 12 are be VBP cord-015021-pol2qm74 5823 13 released release VBN cord-015021-pol2qm74 5823 14 into into IN cord-015021-pol2qm74 5823 15 circulation circulation NN cord-015021-pol2qm74 5823 16 in in IN cord-015021-pol2qm74 5823 17 the the DT cord-015021-pol2qm74 5823 18 acute acute JJ cord-015021-pol2qm74 5823 19 phase phase NN cord-015021-pol2qm74 5823 20 response response NN cord-015021-pol2qm74 5823 21 . . . cord-015021-pol2qm74 5824 1 This this DT cord-015021-pol2qm74 5824 2 study study NN cord-015021-pol2qm74 5824 3 examines examine VBZ cord-015021-pol2qm74 5824 4 the the DT cord-015021-pol2qm74 5824 5 kinetics kinetic NNS cord-015021-pol2qm74 5824 6 of of IN cord-015021-pol2qm74 5824 7 five five CD cord-015021-pol2qm74 5824 8 acute acute JJ cord-015021-pol2qm74 5824 9 phase phase NN cord-015021-pol2qm74 5824 10 proteins protein NNS cord-015021-pol2qm74 5824 11 ( ( -LRB- cord-015021-pol2qm74 5824 12 CRP CRP NNP cord-015021-pol2qm74 5824 13 , , , cord-015021-pol2qm74 5824 14 IL-6 IL-6 NNP cord-015021-pol2qm74 5824 15 , , , cord-015021-pol2qm74 5824 16 TNFot TNFot NNP cord-015021-pol2qm74 5824 17 , , , cord-015021-pol2qm74 5824 18 sTNFR55 stnfr55 CD cord-015021-pol2qm74 5824 19 , , , cord-015021-pol2qm74 5824 20 sTNFR75 stnfr75 CD cord-015021-pol2qm74 5824 21 ) ) -RRB- cord-015021-pol2qm74 5824 22 in in IN cord-015021-pol2qm74 5824 23 patients patient NNS cord-015021-pol2qm74 5824 24 suffering suffer VBG cord-015021-pol2qm74 5824 25 from from IN cord-015021-pol2qm74 5824 26 SIRS SIRS NNP cord-015021-pol2qm74 5824 27 . . . cord-015021-pol2qm74 5825 1 Eighteen eighteen CD cord-015021-pol2qm74 5825 2 patients patient NNS cord-015021-pol2qm74 5825 3 entered enter VBD cord-015021-pol2qm74 5825 4 the the DT cord-015021-pol2qm74 5825 5 study study NN cord-015021-pol2qm74 5825 6 after after IN cord-015021-pol2qm74 5825 7 diagnosis diagnosis NN cord-015021-pol2qm74 5825 8 of of IN cord-015021-pol2qm74 5825 9 SIRS SIRS NNP cord-015021-pol2qm74 5825 10 . . . cord-015021-pol2qm74 5826 1 Blood blood NN cord-015021-pol2qm74 5826 2 samples sample NNS cord-015021-pol2qm74 5826 3 were be VBD cord-015021-pol2qm74 5826 4 drawn draw VBN cord-015021-pol2qm74 5826 5 every every DT cord-015021-pol2qm74 5826 6 six six CD cord-015021-pol2qm74 5826 7 hours hour NNS cord-015021-pol2qm74 5826 8 during during IN cord-015021-pol2qm74 5826 9 the the DT cord-015021-pol2qm74 5826 10 first first JJ cord-015021-pol2qm74 5826 11 two two CD cord-015021-pol2qm74 5826 12 days day NNS cord-015021-pol2qm74 5826 13 and and CC cord-015021-pol2qm74 5826 14 every every DT cord-015021-pol2qm74 5826 15 twelve twelve CD cord-015021-pol2qm74 5826 16 hours hour NNS cord-015021-pol2qm74 5826 17 thereafter thereafter RB cord-015021-pol2qm74 5826 18 . . . cord-015021-pol2qm74 5827 1 CRP CRP NNP cord-015021-pol2qm74 5827 2 was be VBD cord-015021-pol2qm74 5827 3 measured measure VBN cord-015021-pol2qm74 5827 4 in in IN cord-015021-pol2qm74 5827 5 an an DT cord-015021-pol2qm74 5827 6 routine routine JJ cord-015021-pol2qm74 5827 7 turbimetric turbimetric NN cord-015021-pol2qm74 5827 8 assay assay NN cord-015021-pol2qm74 5827 9 . . . cord-015021-pol2qm74 5828 1 IL-6 IL-6 NNP cord-015021-pol2qm74 5828 2 was be VBD cord-015021-pol2qm74 5828 3 detected detect VBN cord-015021-pol2qm74 5828 4 in in IN cord-015021-pol2qm74 5828 5 an an DT cord-015021-pol2qm74 5828 6 biological biological JJ cord-015021-pol2qm74 5828 7 assay assay NN cord-015021-pol2qm74 5828 8 using use VBG cord-015021-pol2qm74 5828 9 the the DT cord-015021-pol2qm74 5828 10 / / SYM cord-015021-pol2qm74 5828 11 L-6 L-6 NNP cord-015021-pol2qm74 5828 12 dependent dependent JJ cord-015021-pol2qm74 5828 13 13-cell 13-cell CD cord-015021-pol2qm74 5828 14 line line NN cord-015021-pol2qm74 5828 15 1313/29 1313/29 CD cord-015021-pol2qm74 5828 16 . . . cord-015021-pol2qm74 5829 1 Detection detection NN cord-015021-pol2qm74 5829 2 of of IN cord-015021-pol2qm74 5829 3 TNFc~ TNFc~ NNP cord-015021-pol2qm74 5829 4 was be VBD cord-015021-pol2qm74 5829 5 performed perform VBN cord-015021-pol2qm74 5829 6 in in IN cord-015021-pol2qm74 5829 7 an an DT cord-015021-pol2qm74 5829 8 ELISA ELISA NNP cord-015021-pol2qm74 5829 9 system system NN cord-015021-pol2qm74 5829 10 using use VBG cord-015021-pol2qm74 5829 11 a a DT cord-015021-pol2qm74 5829 12 monoclonal monoclonal JJ cord-015021-pol2qm74 5829 13 antibody antibody NN cord-015021-pol2qm74 5829 14 " " '' cord-015021-pol2qm74 5829 15 for for IN cord-015021-pol2qm74 5829 16 TNFo~. TNFo~. NNP cord-015021-pol2qm74 5829 17 Soluble soluble JJ cord-015021-pol2qm74 5829 18 TNF TNF NNP cord-015021-pol2qm74 5829 19 receptors receptor NNS cord-015021-pol2qm74 5829 20 were be VBD cord-015021-pol2qm74 5829 21 also also RB cord-015021-pol2qm74 5829 22 measured measure VBN cord-015021-pol2qm74 5829 23 by by IN cord-015021-pol2qm74 5829 24 ELISA ELISA NNP cord-015021-pol2qm74 5829 25 . . . cord-015021-pol2qm74 5830 1 CRP CRP NNP cord-015021-pol2qm74 5830 2 levels level NNS cord-015021-pol2qm74 5830 3 were be VBD cord-015021-pol2qm74 5830 4 elevated elevate VBN cord-015021-pol2qm74 5830 5 ( ( -LRB- cord-015021-pol2qm74 5830 6 > > NFP cord-015021-pol2qm74 5830 7 10 10 CD cord-015021-pol2qm74 5830 8 mg mg NNP cord-015021-pol2qm74 5830 9 / / SYM cord-015021-pol2qm74 5830 10 L L NNP cord-015021-pol2qm74 5830 11 ) ) -RRB- cord-015021-pol2qm74 5830 12 in in IN cord-015021-pol2qm74 5830 13 all all DT cord-015021-pol2qm74 5830 14 patients patient NNS cord-015021-pol2qm74 5830 15 and and CC cord-015021-pol2qm74 5830 16 at at IN cord-015021-pol2qm74 5830 17 all all DT cord-015021-pol2qm74 5830 18 time time NN cord-015021-pol2qm74 5830 19 points point NNS cord-015021-pol2qm74 5830 20 . . . cord-015021-pol2qm74 5831 1 CRP CRP NNP cord-015021-pol2qm74 5831 2 values value NNS cord-015021-pol2qm74 5831 3 did do VBD cord-015021-pol2qm74 5831 4 neither neither DT cord-015021-pol2qm74 5831 5 differ differ VB cord-015021-pol2qm74 5831 6 significantly significantly RB cord-015021-pol2qm74 5831 7 in in IN cord-015021-pol2qm74 5831 8 patients patient NNS cord-015021-pol2qm74 5831 9 with with IN cord-015021-pol2qm74 5831 10 ( ( -LRB- cord-015021-pol2qm74 5831 11 143±33 143±33 CD cord-015021-pol2qm74 5831 12 mg mg NNP cord-015021-pol2qm74 5831 13 / / SYM cord-015021-pol2qm74 5831 14 L L NNP cord-015021-pol2qm74 5831 15 ) ) -RRB- cord-015021-pol2qm74 5831 16 or or CC cord-015021-pol2qm74 5831 17 without without IN cord-015021-pol2qm74 5831 18 ( ( -LRB- cord-015021-pol2qm74 5831 19 129a:39 129a:39 CD cord-015021-pol2qm74 5831 20 ) ) -RRB- cord-015021-pol2qm74 5831 21 multiple multiple JJ cord-015021-pol2qm74 5831 22 organ organ NN cord-015021-pol2qm74 5831 23 failure failure NN cord-015021-pol2qm74 5831 24 ( ( -LRB- cord-015021-pol2qm74 5831 25 MOF MOF NNP cord-015021-pol2qm74 5831 26 ) ) -RRB- cord-015021-pol2qm74 5831 27 nor nor CC cord-015021-pol2qm74 5831 28 in in IN cord-015021-pol2qm74 5831 29 survivors survivor NNS cord-015021-pol2qm74 5831 30 ( ( -LRB- cord-015021-pol2qm74 5831 31 133±41 133±41 CD cord-015021-pol2qm74 5831 32 ) ) -RRB- cord-015021-pol2qm74 5831 33 or or CC cord-015021-pol2qm74 5831 34 non non NNS cord-015021-pol2qm74 5831 35 - - NNS cord-015021-pol2qm74 5831 36 survivors survivor NNS cord-015021-pol2qm74 5831 37 ( ( -LRB- cord-015021-pol2qm74 5831 38 147 147 CD cord-015021-pol2qm74 5831 39 : : : cord-015021-pol2qm74 5831 40 t:44 t:44 CD cord-015021-pol2qm74 5831 41 ) ) -RRB- cord-015021-pol2qm74 5831 42 . . . cord-015021-pol2qm74 5832 1 In in IN cord-015021-pol2qm74 5832 2 contrast contrast NN cord-015021-pol2qm74 5832 3 , , , cord-015021-pol2qm74 5832 4 1L-6 1l-6 CD cord-015021-pol2qm74 5832 5 was be VBD cord-015021-pol2qm74 5832 6 elevated elevate VBN cord-015021-pol2qm74 5832 7 in in IN cord-015021-pol2qm74 5832 8 patients patient NNS cord-015021-pol2qm74 5832 9 wilh wilh NNP cord-015021-pol2qm74 5832 10 MOF MOF NNP cord-015021-pol2qm74 5832 11 ( ( -LRB- cord-015021-pol2qm74 5832 12 mean mean VBP cord-015021-pol2qm74 5832 13 740 740 CD cord-015021-pol2qm74 5832 14 pg pg NN cord-015021-pol2qm74 5832 15 / / SYM cord-015021-pol2qm74 5832 16 ml ml NN cord-015021-pol2qm74 5832 17 , , , cord-015021-pol2qm74 5832 18 range range VBP cord-015021-pol2qm74 5832 19 0 0 CD cord-015021-pol2qm74 5832 20 - - HYPH cord-015021-pol2qm74 5832 21 8900 8900 CD cord-015021-pol2qm74 5832 22 pg pg NN cord-015021-pol2qm74 5832 23 / / SYM cord-015021-pol2qm74 5832 24 ml ml NNP cord-015021-pol2qm74 5832 25 ) ) -RRB- cord-015021-pol2qm74 5832 26 . . . cord-015021-pol2qm74 5833 1 IL-6 IL-6 NNP cord-015021-pol2qm74 5833 2 levels level NNS cord-015021-pol2qm74 5833 3 correlated correlate VBN cord-015021-pol2qm74 5833 4 especially especially RB cord-015021-pol2qm74 5833 5 with with IN cord-015021-pol2qm74 5833 6 lung lung NN cord-015021-pol2qm74 5833 7 dysfunction dysfunction NN cord-015021-pol2qm74 5833 8 . . . cord-015021-pol2qm74 5834 1 TNF(x tnf(x NN cord-015021-pol2qm74 5834 2 levels level NNS cord-015021-pol2qm74 5834 3 were be VBD cord-015021-pol2qm74 5834 4 consistently consistently RB cord-015021-pol2qm74 5834 5 elevated elevate VBN cord-015021-pol2qm74 5834 6 in in IN cord-015021-pol2qm74 5834 7 patients patient NNS cord-015021-pol2qm74 5834 8 with with IN cord-015021-pol2qm74 5834 9 MOF MOF NNP cord-015021-pol2qm74 5834 10 . . . cord-015021-pol2qm74 5835 1 CRP CRP NNP cord-015021-pol2qm74 5835 2 , , , cord-015021-pol2qm74 5835 3 IL-6 IL-6 NNP cord-015021-pol2qm74 5835 4 and and CC cord-015021-pol2qm74 5835 5 TNFoc TNFoc NNP cord-015021-pol2qm74 5835 6 did do VBD cord-015021-pol2qm74 5835 7 not not RB cord-015021-pol2qm74 5835 8 correlate correlate VB cord-015021-pol2qm74 5835 9 with with IN cord-015021-pol2qm74 5835 10 each each DT cord-015021-pol2qm74 5835 11 other other JJ cord-015021-pol2qm74 5835 12 . . . cord-015021-pol2qm74 5836 1 In in IN cord-015021-pol2qm74 5836 2 contrast contrast NN cord-015021-pol2qm74 5836 3 , , , cord-015021-pol2qm74 5836 4 levels level NNS cord-015021-pol2qm74 5836 5 for for IN cord-015021-pol2qm74 5836 6 both both DT cord-015021-pol2qm74 5836 7 sTNFR stnfr RB cord-015021-pol2qm74 5836 8 showed show VBD cord-015021-pol2qm74 5836 9 a a DT cord-015021-pol2qm74 5836 10 positive positive JJ cord-015021-pol2qm74 5836 11 correlation correlation NN cord-015021-pol2qm74 5836 12 ( ( -LRB- cord-015021-pol2qm74 5836 13 r=0.7 r=0.7 NNP cord-015021-pol2qm74 5836 14 ) ) -RRB- cord-015021-pol2qm74 5836 15 . . . cord-015021-pol2qm74 5837 1 Patients patient NNS cord-015021-pol2qm74 5837 2 could could MD cord-015021-pol2qm74 5837 3 be be VB cord-015021-pol2qm74 5837 4 divided divide VBN cord-015021-pol2qm74 5837 5 into into IN cord-015021-pol2qm74 5837 6 two two CD cord-015021-pol2qm74 5837 7 groups group NNS cord-015021-pol2qm74 5837 8 by by IN cord-015021-pol2qm74 5837 9 values value NNS cord-015021-pol2qm74 5837 10 for for IN cord-015021-pol2qm74 5837 11 sTNFR~5 sTNFR~5 NNP cord-015021-pol2qm74 5837 12 and and CC cord-015021-pol2qm74 5837 13 sTNFR75 sTNFR75 NNS cord-015021-pol2qm74 5837 14 : : : cord-015021-pol2qm74 5838 1 The the DT cord-015021-pol2qm74 5838 2 group group NN cord-015021-pol2qm74 5838 3 with with IN cord-015021-pol2qm74 5838 4 higher high JJR cord-015021-pol2qm74 5838 5 soluble soluble JJ cord-015021-pol2qm74 5838 6 TNF TNF NNP cord-015021-pol2qm74 5838 7 receptor receptor NN cord-015021-pol2qm74 5838 8 levels level NNS cord-015021-pol2qm74 5838 9 showed show VBD cord-015021-pol2qm74 5838 10 increasing increase VBG cord-015021-pol2qm74 5838 11 values value NNS cord-015021-pol2qm74 5838 12 combined combine VBN cord-015021-pol2qm74 5838 13 with with IN cord-015021-pol2qm74 5838 14 a a DT cord-015021-pol2qm74 5838 15 poor poor JJ cord-015021-pol2qm74 5838 16 prognosis prognosis NN cord-015021-pol2qm74 5838 17 . . . cord-015021-pol2qm74 5839 1 The the DT cord-015021-pol2qm74 5839 2 group group NN cord-015021-pol2qm74 5839 3 with with IN cord-015021-pol2qm74 5839 4 lower low JJR cord-015021-pol2qm74 5839 5 levels level NNS cord-015021-pol2qm74 5839 6 of of IN cord-015021-pol2qm74 5839 7 soluble soluble JJ cord-015021-pol2qm74 5839 8 TNF TNF NNP cord-015021-pol2qm74 5839 9 receptor receptor NN cord-015021-pol2qm74 5839 10 consisted consist VBD cord-015021-pol2qm74 5839 11 of of IN cord-015021-pol2qm74 5839 12 patients patient NNS cord-015021-pol2qm74 5839 13 surviving survive VBG cord-015021-pol2qm74 5839 14 MOF MOF NNP cord-015021-pol2qm74 5839 15 or or CC cord-015021-pol2qm74 5839 16 without without IN cord-015021-pol2qm74 5839 17 MOF MOF NNP cord-015021-pol2qm74 5839 18 . . . cord-015021-pol2qm74 5840 1 In in IN cord-015021-pol2qm74 5840 2 conclusion conclusion NN cord-015021-pol2qm74 5840 3 , , , cord-015021-pol2qm74 5840 4 CRP CRP NNP cord-015021-pol2qm74 5840 5 does do VBZ cord-015021-pol2qm74 5840 6 not not RB cord-015021-pol2qm74 5840 7 monitor monitor VB cord-015021-pol2qm74 5840 8 the the DT cord-015021-pol2qm74 5840 9 course course NN cord-015021-pol2qm74 5840 10 of of IN cord-015021-pol2qm74 5840 11 SIRS SIRS NNP cord-015021-pol2qm74 5840 12 adequately adequately RB cord-015021-pol2qm74 5840 13 . . . cord-015021-pol2qm74 5841 1 In in IN cord-015021-pol2qm74 5841 2 contrast contrast NN cord-015021-pol2qm74 5841 3 , , , cord-015021-pol2qm74 5841 4 IL-6 IL-6 NNP cord-015021-pol2qm74 5841 5 correlates correlate VBZ cord-015021-pol2qm74 5841 6 with with IN cord-015021-pol2qm74 5841 7 MOF MOF NNP cord-015021-pol2qm74 5841 8 and and CC cord-015021-pol2qm74 5841 9 episodes episode NNS cord-015021-pol2qm74 5841 10 of of IN cord-015021-pol2qm74 5841 11 high high JJ cord-015021-pol2qm74 5841 12 disease disease NN cord-015021-pol2qm74 5841 13 activity activity NN cord-015021-pol2qm74 5841 14 . . . cord-015021-pol2qm74 5842 1 High high JJ cord-015021-pol2qm74 5842 2 sTNFR stnfr NN cord-015021-pol2qm74 5842 3 levels level NNS cord-015021-pol2qm74 5842 4 may may MD cord-015021-pol2qm74 5842 5 indicate indicate VB cord-015021-pol2qm74 5842 6 poor poor JJ cord-015021-pol2qm74 5842 7 prognosis prognosis NN cord-015021-pol2qm74 5842 8 . . . cord-015021-pol2qm74 5843 1 Klinik Klinik NNP cord-015021-pol2qm74 5843 2 F0r F0r NNP cord-015021-pol2qm74 5844 1 An an DT cord-015021-pol2qm74 5844 2 / / SYM cord-015021-pol2qm74 5844 3 isthesiologie isthesiologie NN cord-015021-pol2qm74 5844 4 and and CC cord-015021-pol2qm74 5844 5 Operative Operative NNP cord-015021-pol2qm74 5844 6 Intensivmedizin Intensivmedizin NNP cord-015021-pol2qm74 5844 7 der der NNP cord-015021-pol2qm74 5844 8 CAU CAU NNP cord-015021-pol2qm74 5844 9 Kiel Kiel NNP cord-015021-pol2qm74 5844 10 , , , cord-015021-pol2qm74 5844 11 Schwanenweg Schwanenweg NNP cord-015021-pol2qm74 5844 12 21 21 CD cord-015021-pol2qm74 5844 13 , , , cord-015021-pol2qm74 5844 14 24105 24105 CD cord-015021-pol2qm74 5844 15 Kiei Kiei NNP cord-015021-pol2qm74 5844 16 , , , cord-015021-pol2qm74 5844 17 Germany Germany NNP cord-015021-pol2qm74 5844 18 . . . cord-015021-pol2qm74 5845 1 Ch Ch NNP cord-015021-pol2qm74 5845 2 . . . cord-015021-pol2qm74 5846 1 Waydhas Waydhas NNP cord-015021-pol2qm74 5846 2 , , , cord-015021-pol2qm74 5846 3 MD MD NNP cord-015021-pol2qm74 5846 4 ; ; : cord-015021-pol2qm74 5846 5 D. D. NNP cord-015021-pol2qm74 5846 6 Nast Nast NNP cord-015021-pol2qm74 5846 7 - - HYPH cord-015021-pol2qm74 5846 8 Kolb Kolb NNP cord-015021-pol2qm74 5846 9 , , , cord-015021-pol2qm74 5846 10 ivID ivid NN cord-015021-pol2qm74 5846 11 ; ; : cord-015021-pol2qm74 5846 12 M. M. NNP cord-015021-pol2qm74 5846 13 Jochum Jochum NNP cord-015021-pol2qm74 5846 14 , , , cord-015021-pol2qm74 5846 15 Phi Phi NNP cord-015021-pol2qm74 5846 16 ) ) -RRB- cord-015021-pol2qm74 5846 17 ; ; : cord-015021-pol2qm74 5846 18 L. L. NNP cord-015021-pol2qm74 5846 19 Schweiberer Schweiberer NNP cord-015021-pol2qm74 5846 20 , , , cord-015021-pol2qm74 5846 21 MI MI NNP cord-015021-pol2qm74 5847 1 ) ) -RRB- cord-015021-pol2qm74 5847 2 Objective objective NN cord-015021-pol2qm74 5847 3 : : : cord-015021-pol2qm74 5847 4 To to TO cord-015021-pol2qm74 5847 5 evaluate evaluate VB cord-015021-pol2qm74 5847 6 the the DT cord-015021-pol2qm74 5847 7 irfflarranatory irfflarranatory NNP cord-015021-pol2qm74 5847 8 response response NN cord-015021-pol2qm74 5847 9 after after IN cord-015021-pol2qm74 5847 10 different different JJ cord-015021-pol2qm74 5847 11 types type NNS cord-015021-pol2qm74 5847 12 of of IN cord-015021-pol2qm74 5847 13 orthopedic orthopedic NN cord-015021-pol2qm74 5847 14 operations operation NNS cord-015021-pol2qm74 5847 15 and and CC cord-015021-pol2qm74 5847 16 compare compare VB cord-015021-pol2qm74 5847 17 them -PRON- PRP cord-015021-pol2qm74 5847 18 with with IN cord-015021-pol2qm74 5847 19 the the DT cord-015021-pol2qm74 5847 20 systemic systemic JJ cord-015021-pol2qm74 5847 21 effects effect NNS cord-015021-pol2qm74 5847 22 of of IN cord-015021-pol2qm74 5847 23 accidental accidental JJ cord-015021-pol2qm74 5847 24 trauma trauma NN cord-015021-pol2qm74 5847 25 of of IN cord-015021-pol2qm74 5847 26 varying vary VBG cord-015021-pol2qm74 5847 27 severity severity NN cord-015021-pol2qm74 5847 28 . . . cord-015021-pol2qm74 5848 1 Patients patient NNS cord-015021-pol2qm74 5848 2 : : : cord-015021-pol2qm74 5848 3 In in IN cord-015021-pol2qm74 5848 4 135 135 CD cord-015021-pol2qm74 5848 5 consecutive consecutive JJ cord-015021-pol2qm74 5848 6 patients patient NNS cord-015021-pol2qm74 5848 7 with with IN cord-015021-pol2qm74 5848 8 multiple multiple JJ cord-015021-pol2qm74 5848 9 injuries injury NNS cord-015021-pol2qm74 5848 10 ( ( -LRB- cord-015021-pol2qm74 5848 11 ISS ISS NNP cord-015021-pol2qm74 5848 12 40.6 40.6 CD cord-015021-pol2qm74 5848 13 ) ) -RRB- cord-015021-pol2qm74 5849 1 the the DT cord-015021-pol2qm74 5849 2 inflammatory inflammatory JJ cord-015021-pol2qm74 5849 3 response response NN cord-015021-pol2qm74 5849 4 to to IN cord-015021-pol2qm74 5849 5 trauma trauma NN cord-015021-pol2qm74 5849 6 was be VBD cord-015021-pol2qm74 5849 7 prospectively prospectively RB cord-015021-pol2qm74 5849 8 studied study VBN cord-015021-pol2qm74 5849 9 . . . cord-015021-pol2qm74 5850 1 The the DT cord-015021-pol2qm74 5850 2 patients patient NNS cord-015021-pol2qm74 5850 3 were be VBD cord-015021-pol2qm74 5850 4 divided divide VBN cord-015021-pol2qm74 5850 5 into into IN cord-015021-pol2qm74 5850 6 4 4 CD cord-015021-pol2qm74 5850 7 groups group NNS cord-015021-pol2qm74 5850 8 according accord VBG cord-015021-pol2qm74 5850 9 to to IN cord-015021-pol2qm74 5850 10 their -PRON- PRP$ cord-015021-pol2qm74 5850 11 ISS ISS NNP cord-015021-pol2qm74 5850 12 points point NNS cord-015021-pol2qm74 5850 13 . . . cord-015021-pol2qm74 5851 1 Additionally additionally RB cord-015021-pol2qm74 5851 2 , , , cord-015021-pol2qm74 5851 3 the the DT cord-015021-pol2qm74 5851 4 alterations alteration NNS cord-015021-pol2qm74 5851 5 after after IN cord-015021-pol2qm74 5851 6 79 79 CD cord-015021-pol2qm74 5851 7 secondary secondary JJ cord-015021-pol2qm74 5851 8 operations operation NNS cord-015021-pol2qm74 5851 9 ( ( -LRB- cord-015021-pol2qm74 5851 10 > > NFP cord-015021-pol2qm74 5851 11 24 24 CD cord-015021-pol2qm74 5851 12 hr hr NN cord-015021-pol2qm74 5851 13 ) ) -RRB- cord-015021-pol2qm74 5851 14 were be VBD cord-015021-pol2qm74 5851 15 determined determine VBN cord-015021-pol2qm74 5851 16 ( ( -LRB- cord-015021-pol2qm74 5851 17 msteosynthesis msteosynthesis NN cord-015021-pol2qm74 5851 18 of of IN cord-015021-pol2qm74 5851 19 the the DT cord-015021-pol2qm74 5851 20 femur femur NN cord-015021-pol2qm74 5851 21 ( ( -LRB- cord-015021-pol2qm74 5851 22 n=28 n=28 RB cord-015021-pol2qm74 5851 23 ) ) -RRB- cord-015021-pol2qm74 5851 24 , , , cord-015021-pol2qm74 5851 25 pelvic pelvic JJ cord-015021-pol2qm74 5851 26 girdle girdle NN cord-015021-pol2qm74 5851 27 ( ( -LRB- cord-015021-pol2qm74 5851 28 n n NN cord-015021-pol2qm74 5851 29 = = SYM cord-015021-pol2qm74 5851 30 ll ll NNP cord-015021-pol2qm74 5851 31 ) ) -RRB- cord-015021-pol2qm74 5851 32 and and CC cord-015021-pol2qm74 5851 33 spine spine NN cord-015021-pol2qm74 5851 34 ( ( -LRB- cord-015021-pol2qm74 5851 35 n=8 n=8 NN cord-015021-pol2qm74 5851 36 ) ) -RRB- cord-015021-pol2qm74 5851 37 , , , cord-015021-pol2qm74 5851 38 facial facial JJ cord-015021-pol2qm74 5851 39 reconstruction reconstruction NN cord-015021-pol2qm74 5851 40 ( ( -LRB- cord-015021-pol2qm74 5851 41 n=13 n=13 NNP cord-015021-pol2qm74 5851 42 ) ) -RRB- cord-015021-pol2qm74 5851 43 , , , cord-015021-pol2qm74 5851 44 smaller small JJR cord-015021-pol2qm74 5851 45 osteosynthesis osteosynthesis NNP cord-015021-pol2qm74 5851 46 ( ( -LRB- cord-015021-pol2qm74 5851 47 n=13 n=13 NNP cord-015021-pol2qm74 5851 48 ) ) -RRB- cord-015021-pol2qm74 5851 49 and and CC cord-015021-pol2qm74 5851 50 others other NNS cord-015021-pol2qm74 5851 51 ( ( -LRB- cord-015021-pol2qm74 5851 52 n=6 n=6 NNP cord-015021-pol2qm74 5851 53 ) ) -RRB- cord-015021-pol2qm74 5851 54 ) ) -RRB- cord-015021-pol2qm74 5851 55 . . . cord-015021-pol2qm74 5852 1 Methods method NNS cord-015021-pol2qm74 5852 2 : : : cord-015021-pol2qm74 5852 3 Specific specific JJ cord-015021-pol2qm74 5852 4 and and CC cord-015021-pol2qm74 5852 5 unspecific unspecific JJ cord-015021-pol2qm74 5852 6 parameters parameter NNS cord-015021-pol2qm74 5852 7 of of IN cord-015021-pol2qm74 5852 8 the the DT cord-015021-pol2qm74 5852 9 inflammatory inflammatory JJ cord-015021-pol2qm74 5852 10 response response NN cord-015021-pol2qm74 5852 11 were be VBD cord-015021-pol2qm74 5852 12 determined determine VBN cord-015021-pol2qm74 5852 13 in in IN cord-015021-pol2qm74 5852 14 the the DT cord-015021-pol2qm74 5852 15 trauma trauma NN cord-015021-pol2qm74 5852 16 patients patient NNS cord-015021-pol2qm74 5852 17 every every DT cord-015021-pol2qm74 5852 18 6 6 CD cord-015021-pol2qm74 5852 19 h h NN cord-015021-pol2qm74 5852 20 , , , cord-015021-pol2qm74 5852 21 beginning begin VBG cord-015021-pol2qm74 5852 22 on on IN cord-015021-pol2qm74 5852 23 admission admission NN cord-015021-pol2qm74 5852 24 of of IN cord-015021-pol2qm74 5852 25 the the DT cord-015021-pol2qm74 5852 26 patient patient NN cord-015021-pol2qm74 5852 27 to to IN cord-015021-pol2qm74 5852 28 the the DT cord-015021-pol2qm74 5852 29 emergency emergency NN cord-015021-pol2qm74 5852 30 room room NN cord-015021-pol2qm74 5852 31 for for IN cord-015021-pol2qm74 5852 32 a a DT cord-015021-pol2qm74 5852 33 period period NN cord-015021-pol2qm74 5852 34 of of IN cord-015021-pol2qm74 5852 35 48 48 CD cord-015021-pol2qm74 5852 36 hr hr NN cord-015021-pol2qm74 5852 37 , , , cord-015021-pol2qm74 5852 38 and and CC cord-015021-pol2qm74 5852 39 in in IN cord-015021-pol2qm74 5852 40 the the DT cord-015021-pol2qm74 5852 41 operative operative JJ cord-015021-pol2qm74 5852 42 patients patient NNS cord-015021-pol2qm74 5852 43 on on IN cord-015021-pol2qm74 5852 44 the the DT cord-015021-pol2qm74 5852 45 morning morning NN cord-015021-pol2qm74 5852 46 of of IN cord-015021-pol2qm74 5852 47 the the DT cord-015021-pol2qm74 5852 48 operation operation NN cord-015021-pol2qm74 5852 49 , , , cord-015021-pol2qm74 5852 50 at at IN cord-015021-pol2qm74 5852 51 the the DT cord-015021-pol2qm74 5852 52 end end NN cord-015021-pol2qm74 5852 53 of of IN cord-015021-pol2qm74 5852 54 the the DT cord-015021-pol2qm74 5852 55 procedure procedure NN cord-015021-pol2qm74 5852 56 and and CC cord-015021-pol2qm74 5852 57 every every DT cord-015021-pol2qm74 5852 58 6 6 CD cord-015021-pol2qm74 5852 59 hr hr NN cord-015021-pol2qm74 5852 60 during during IN cord-015021-pol2qm74 5852 61 the the DT cord-015021-pol2qm74 5852 62 first first JJ cord-015021-pol2qm74 5852 63 two two CD cord-015021-pol2qm74 5852 64 days day NNS cord-015021-pol2qm74 5852 65 . . . cord-015021-pol2qm74 5853 1 Results result NNS cord-015021-pol2qm74 5853 2 : : : cord-015021-pol2qm74 5854 1 Lactate lactate NN cord-015021-pol2qm74 5854 2 , , , cord-015021-pol2qm74 5854 3 neutrophil neutrophil NN cord-015021-pol2qm74 5854 4 elastase elastase NN cord-015021-pol2qm74 5854 5 , , , cord-015021-pol2qm74 5854 6 heart heart NN cord-015021-pol2qm74 5854 7 rate rate NN cord-015021-pol2qm74 5854 8 , , , cord-015021-pol2qm74 5854 9 pO2 pO2 NNP cord-015021-pol2qm74 5854 10 / / SYM cord-015021-pol2qm74 5854 11 FiO2-ratio FiO2-ratio NNP cord-015021-pol2qm74 5854 12 , , , cord-015021-pol2qm74 5854 13 and and CC cord-015021-pol2qm74 5854 14 other other JJ cord-015021-pol2qm74 5854 15 parameters parameter NNS cord-015021-pol2qm74 5854 16 discriminated discriminate VBN cord-015021-pol2qm74 5854 17 significantly significantly RB cord-015021-pol2qm74 5854 18 between between IN cord-015021-pol2qm74 5854 19 the the DT cord-015021-pol2qm74 5854 20 4 4 CD cord-015021-pol2qm74 5854 21 injury injury NN cord-015021-pol2qm74 5854 22 severity severity NN cord-015021-pol2qm74 5854 23 groups group NNS cord-015021-pol2qm74 5854 24 during during IN cord-015021-pol2qm74 5854 25 the the DT cord-015021-pol2qm74 5854 26 first first JJ cord-015021-pol2qm74 5854 27 48 48 CD cord-015021-pol2qm74 5854 28 hr hr NN cord-015021-pol2qm74 5854 29 ( ( -LRB- cord-015021-pol2qm74 5854 30 Kruskal Kruskal NNP cord-015021-pol2qm74 5854 31 - - HYPH cord-015021-pol2qm74 5854 32 Wallis Wallis NNP cord-015021-pol2qm74 5854 33 - - HYPH cord-015021-pol2qm74 5854 34 test test NN cord-015021-pol2qm74 5854 35 , , , cord-015021-pol2qm74 5854 36 p<.05 p<.05 NNP cord-015021-pol2qm74 5854 37 ) ) -RRB- cord-015021-pol2qm74 5854 38 . . . cord-015021-pol2qm74 5855 1 The the DT cord-015021-pol2qm74 5855 2 degree degree NN cord-015021-pol2qm74 5855 3 of of IN cord-015021-pol2qm74 5855 4 postoperative postoperative JJ cord-015021-pol2qm74 5855 5 changes change NNS cord-015021-pol2qm74 5855 6 differed differ VBD cord-015021-pol2qm74 5855 7 significantly significantly RB cord-015021-pol2qm74 5855 8 ( ( -LRB- cord-015021-pol2qm74 5855 9 Kmskal Kmskal NNP cord-015021-pol2qm74 5855 10 - - HYPH cord-015021-pol2qm74 5855 11 Wallis Wallis NNP cord-015021-pol2qm74 5855 12 - - HYPH cord-015021-pol2qm74 5855 13 test test NN cord-015021-pol2qm74 5855 14 , , , cord-015021-pol2qm74 5855 15 p<.05 p<.05 NNP cord-015021-pol2qm74 5855 16 ) ) -RRB- cord-015021-pol2qm74 5855 17 between between IN cord-015021-pol2qm74 5855 18 the the DT cord-015021-pol2qm74 5855 19 5 5 CD cord-015021-pol2qm74 5855 20 types type NNS cord-015021-pol2qm74 5855 21 of of IN cord-015021-pol2qm74 5855 22 operations operation NNS cord-015021-pol2qm74 5855 23 for for IN cord-015021-pol2qm74 5855 24 lactate lactate NN cord-015021-pol2qm74 5855 25 , , , cord-015021-pol2qm74 5855 26 heart heart NN cord-015021-pol2qm74 5855 27 rate rate NN cord-015021-pol2qm74 5855 28 , , , cord-015021-pol2qm74 5855 29 pO2 pO2 NNP cord-015021-pol2qm74 5855 30 / / SYM cord-015021-pol2qm74 5855 31 FiO2-ratio FiO2-ratio NNP cord-015021-pol2qm74 5855 32 , , , cord-015021-pol2qm74 5855 33 nitrogen nitrogen NN cord-015021-pol2qm74 5855 34 excretion excretion NN cord-015021-pol2qm74 5855 35 and and CC cord-015021-pol2qm74 5855 36 showed show VBD cord-015021-pol2qm74 5855 37 a a DT cord-015021-pol2qm74 5855 38 strong strong JJ cord-015021-pol2qm74 5855 39 discriminating discriminating JJ cord-015021-pol2qm74 5855 40 tendency tendency NN cord-015021-pol2qm74 5855 41 for for IN cord-015021-pol2qm74 5855 42 neutrophil neutrophil NN cord-015021-pol2qm74 5855 43 elastase elastase NN cord-015021-pol2qm74 5855 44 and and CC cord-015021-pol2qm74 5855 45 C c NN cord-015021-pol2qm74 5855 46 - - HYPH cord-015021-pol2qm74 5855 47 reactive reactive JJ cord-015021-pol2qm74 5855 48 protein protein NN cord-015021-pol2qm74 5855 49 . . . cord-015021-pol2qm74 5856 1 The the DT cord-015021-pol2qm74 5856 2 extent extent NN cord-015021-pol2qm74 5856 3 of of IN cord-015021-pol2qm74 5856 4 changes change NNS cord-015021-pol2qm74 5856 5 were be VBD cord-015021-pol2qm74 5856 6 highest high JJS cord-015021-pol2qm74 5856 7 after after IN cord-015021-pol2qm74 5856 8 operations operation NNS cord-015021-pol2qm74 5856 9 of of IN cord-015021-pol2qm74 5856 10 the the DT cord-015021-pol2qm74 5856 11 pelvic pelvic JJ cord-015021-pol2qm74 5856 12 girdle girdle NN cord-015021-pol2qm74 5856 13 , , , cord-015021-pol2qm74 5856 14 followed follow VBN cord-015021-pol2qm74 5856 15 by by IN cord-015021-pol2qm74 5856 16 procedures procedure NNS cord-015021-pol2qm74 5856 17 on on IN cord-015021-pol2qm74 5856 18 the the DT cord-015021-pol2qm74 5856 19 femur femur NN cord-015021-pol2qm74 5856 20 , , , cord-015021-pol2qm74 5856 21 spine spine NN cord-015021-pol2qm74 5856 22 , , , cord-015021-pol2qm74 5856 23 smaller small JJR cord-015021-pol2qm74 5856 24 bones bone NNS cord-015021-pol2qm74 5856 25 , , , cord-015021-pol2qm74 5856 26 and and CC cord-015021-pol2qm74 5856 27 the the DT cord-015021-pol2qm74 5856 28 facial facial JJ cord-015021-pol2qm74 5856 29 region region NN cord-015021-pol2qm74 5856 30 . . . cord-015021-pol2qm74 5857 1 The the DT cord-015021-pol2qm74 5857 2 postoperative postoperative JJ cord-015021-pol2qm74 5857 3 changes change NNS cord-015021-pol2qm74 5857 4 after after IN cord-015021-pol2qm74 5857 5 osteosynthesis osteosynthesis NN cord-015021-pol2qm74 5857 6 of of IN cord-015021-pol2qm74 5857 7 the the DT cord-015021-pol2qm74 5857 8 femur femur NN cord-015021-pol2qm74 5857 9 or or CC cord-015021-pol2qm74 5857 10 pelvis pelvi NNS cord-015021-pol2qm74 5857 11 were be VBD cord-015021-pol2qm74 5857 12 comparable comparable JJ cord-015021-pol2qm74 5857 13 to to IN cord-015021-pol2qm74 5857 14 the the DT cord-015021-pol2qm74 5857 15 alterations alteration NNS cord-015021-pol2qm74 5857 16 noticed notice VBN cord-015021-pol2qm74 5857 17 after after IN cord-015021-pol2qm74 5857 18 smaller small JJR cord-015021-pol2qm74 5857 19 ( ( -LRB- cord-015021-pol2qm74 5857 20 ISS ISS NNP cord-015021-pol2qm74 5857 21 1 1 CD cord-015021-pol2qm74 5857 22 to to IN cord-015021-pol2qm74 5857 23 24 24 CD cord-015021-pol2qm74 5857 24 ) ) -RRB- cord-015021-pol2qm74 5857 25 or or CC cord-015021-pol2qm74 5857 26 moderate moderate JJ cord-015021-pol2qm74 5857 27 ( ( -LRB- cord-015021-pol2qm74 5857 28 ISS ISS NNP cord-015021-pol2qm74 5857 29 25 25 CD cord-015021-pol2qm74 5857 30 to to IN cord-015021-pol2qm74 5857 31 40 40 CD cord-015021-pol2qm74 5857 32 ) ) -RRB- cord-015021-pol2qm74 5857 33 accidental accidental JJ cord-015021-pol2qm74 5857 34 trauma trauma NN cord-015021-pol2qm74 5857 35 for for IN cord-015021-pol2qm74 5857 36 neutrophil neutrophil NN cord-015021-pol2qm74 5857 37 elastuse elastuse NN cord-015021-pol2qm74 5857 38 , , , cord-015021-pol2qm74 5857 39 heart heart NN cord-015021-pol2qm74 5857 40 rate rate NN cord-015021-pol2qm74 5857 41 , , , cord-015021-pol2qm74 5857 42 pO2 pO2 NNP cord-015021-pol2qm74 5857 43 / / SYM cord-015021-pol2qm74 5857 44 FiO2-ratio FiO2-ratio NNP cord-015021-pol2qm74 5857 45 and and CC cord-015021-pol2qm74 5857 46 parameters parameter NNS cord-015021-pol2qm74 5857 47 of of IN cord-015021-pol2qm74 5857 48 the the DT cord-015021-pol2qm74 5857 49 coagulation coagulation NN cord-015021-pol2qm74 5857 50 system system NN cord-015021-pol2qm74 5857 51 . . . cord-015021-pol2qm74 5858 1 Conclusions conclusion NNS cord-015021-pol2qm74 5858 2 : : : cord-015021-pol2qm74 5859 1 There there EX cord-015021-pol2qm74 5859 2 is be VBZ cord-015021-pol2qm74 5859 3 a a DT cord-015021-pol2qm74 5859 4 considerable considerable JJ cord-015021-pol2qm74 5859 5 inflammatory inflammatory JJ cord-015021-pol2qm74 5859 6 response response NN cord-015021-pol2qm74 5859 7 to to IN cord-015021-pol2qm74 5859 8 operative operative JJ cord-015021-pol2qm74 5859 9 procedures procedure NNS cord-015021-pol2qm74 5859 10 that that WDT cord-015021-pol2qm74 5859 11 varies vary VBZ cord-015021-pol2qm74 5859 12 with with IN cord-015021-pol2qm74 5859 13 the the DT cord-015021-pol2qm74 5859 14 type type NN cord-015021-pol2qm74 5859 15 of of IN cord-015021-pol2qm74 5859 16 surgery surgery NN cord-015021-pol2qm74 5859 17 . . . cord-015021-pol2qm74 5860 1 Large large JJ cord-015021-pol2qm74 5860 2 operations operation NNS cord-015021-pol2qm74 5860 3 cause cause VBP cord-015021-pol2qm74 5860 4 changes change NNS cord-015021-pol2qm74 5860 5 in in IN cord-015021-pol2qm74 5860 6 the the DT cord-015021-pol2qm74 5860 7 body body NN cord-015021-pol2qm74 5860 8 homeostasis homeostasis NN cord-015021-pol2qm74 5860 9 that that WDT cord-015021-pol2qm74 5860 10 resemble resemble VBP cord-015021-pol2qm74 5860 11 those those DT cord-015021-pol2qm74 5860 12 after after IN cord-015021-pol2qm74 5860 13 multiple multiple JJ cord-015021-pol2qm74 5860 14 injuries injury NNS cord-015021-pol2qm74 5860 15 . . . cord-015021-pol2qm74 5861 1 It -PRON- PRP cord-015021-pol2qm74 5861 2 remains remain VBZ cord-015021-pol2qm74 5861 3 to to TO cord-015021-pol2qm74 5861 4 be be VB cord-015021-pol2qm74 5861 5 established establish VBN cord-015021-pol2qm74 5861 6 whether whether IN cord-015021-pol2qm74 5861 7 the the DT cord-015021-pol2qm74 5861 8 inflammatory inflammatory JJ cord-015021-pol2qm74 5861 9 sequelae sequela NNS cord-015021-pol2qm74 5861 10 of of IN cord-015021-pol2qm74 5861 11 surgical surgical JJ cord-015021-pol2qm74 5861 12 trauma trauma NN cord-015021-pol2qm74 5861 13 are be VBP cord-015021-pol2qm74 5861 14 additive additive NN cord-015021-pol2qm74 5861 15 to to IN cord-015021-pol2qm74 5861 16 the the DT cord-015021-pol2qm74 5861 17 changes change NNS cord-015021-pol2qm74 5861 18 caused cause VBN cord-015021-pol2qm74 5861 19 by by IN cord-015021-pol2qm74 5861 20 accidental accidental JJ cord-015021-pol2qm74 5861 21 trauma trauma NN cord-015021-pol2qm74 5861 22 . . . cord-015021-pol2qm74 5862 1 Objective objective NN cord-015021-pol2qm74 5862 2 of of IN cord-015021-pol2qm74 5862 3 the the DT cord-015021-pol2qm74 5862 4 study study NN cord-015021-pol2qm74 5862 5 : : : cord-015021-pol2qm74 5862 6 We -PRON- PRP cord-015021-pol2qm74 5862 7 retrospectively retrospectively RB cord-015021-pol2qm74 5862 8 compared compare VBD cord-015021-pol2qm74 5862 9 characteristics characteristic NNS cord-015021-pol2qm74 5862 10 of of IN cord-015021-pol2qm74 5862 11 elderly elderly JJ cord-015021-pol2qm74 5862 12 patients patient NNS cord-015021-pol2qm74 5862 13 ( ( -LRB- cord-015021-pol2qm74 5862 14 ~65 ~65 CD cord-015021-pol2qm74 5862 15 years year NNS cord-015021-pol2qm74 5862 16 ) ) -RRB- cord-015021-pol2qm74 5862 17 and and CC cord-015021-pol2qm74 5862 18 yeunger yeunger NNP cord-015021-pol2qm74 5862 19 patients patient NNS cord-015021-pol2qm74 5862 20 admitted admit VBD cord-015021-pol2qm74 5862 21 to to IN cord-015021-pol2qm74 5862 22 a a DT cord-015021-pol2qm74 5862 23 surgical surgical JJ cord-015021-pol2qm74 5862 24 { { -LRB- cord-015021-pol2qm74 5862 25 SICU SICU NNP cord-015021-pol2qm74 5862 26 ) ) -RRB- cord-015021-pol2qm74 5862 27 and and CC cord-015021-pol2qm74 5862 28 a a DT cord-015021-pol2qm74 5862 29 medical medical JJ cord-015021-pol2qm74 5862 30 intensive intensive JJ cord-015021-pol2qm74 5862 31 care care NN cord-015021-pol2qm74 5862 32 unit unit NN cord-015021-pol2qm74 5862 33 ( ( -LRB- cord-015021-pol2qm74 5862 34 MICU MICU NNP cord-015021-pol2qm74 5862 35 ) ) -RRB- cord-015021-pol2qm74 5862 36 . . . cord-015021-pol2qm74 5863 1 We -PRON- PRP cord-015021-pol2qm74 5863 2 further further RB cord-015021-pol2qm74 5863 3 studied study VBD cord-015021-pol2qm74 5863 4 the the DT cord-015021-pol2qm74 5863 5 relations relation NNS cord-015021-pol2qm74 5863 6 between between IN cord-015021-pol2qm74 5863 7 advancing advance VBG cord-015021-pol2qm74 5863 8 age age NN cord-015021-pol2qm74 5863 9 , , , cord-015021-pol2qm74 5863 10 chronic chronic JJ cord-015021-pol2qm74 5863 11 disease disease NN cord-015021-pol2qm74 5863 12 , , , cord-015021-pol2qm74 5863 13 sepsis sepsis NN cord-015021-pol2qm74 5863 14 , , , cord-015021-pol2qm74 5863 15 organ organ NN cord-015021-pol2qm74 5863 16 system system NN cord-015021-pol2qm74 5863 17 failure failure NN cord-015021-pol2qm74 5863 18 ( ( -LRB- cord-015021-pol2qm74 5863 19 OSF OSF NNP cord-015021-pol2qm74 5863 20 ) ) -RRB- cord-015021-pol2qm74 5863 21 and and CC cord-015021-pol2qm74 5863 22 mortality mortality NN cord-015021-pol2qm74 5863 23 in in IN cord-015021-pol2qm74 5863 24 the the DT cord-015021-pol2qm74 5863 25 elderly elderly JJ cord-015021-pol2qm74 5863 26 group group NN cord-015021-pol2qm74 5863 27 . . . cord-015021-pol2qm74 5864 1 Material material NN cord-015021-pol2qm74 5864 2 and and CC cord-015021-pol2qm74 5864 3 methods method NNS cord-015021-pol2qm74 5864 4 : : : cord-015021-pol2qm74 5864 5 During during IN cord-015021-pol2qm74 5864 6 a a DT cord-015021-pol2qm74 5864 7 1-year 1-year CD cord-015021-pol2qm74 5864 8 period period NN cord-015021-pol2qm74 5864 9 , , , cord-015021-pol2qm74 5864 10 538 538 CD cord-015021-pol2qm74 5864 11 patients patient NNS cord-015021-pol2qm74 5864 12 were be VBD cord-015021-pol2qm74 5864 13 consecutively consecutively RB cord-015021-pol2qm74 5864 14 admitted admit VBN cord-015021-pol2qm74 5864 15 into into IN cord-015021-pol2qm74 5864 16 the the DT cord-015021-pol2qm74 5864 17 8ICU 8icu NN cord-015021-pol2qm74 5864 18 ; ; : cord-015021-pol2qm74 5864 19 and and CC cord-015021-pol2qm74 5864 20 during during IN cord-015021-pol2qm74 5864 21 a a DT cord-015021-pol2qm74 5864 22 2-year 2-year CD cord-015021-pol2qm74 5864 23 period period NN cord-015021-pol2qm74 5864 24 , , , cord-015021-pol2qm74 5864 25 487 487 CD cord-015021-pol2qm74 5864 26 patients patient NNS cord-015021-pol2qm74 5864 27 were be VBD cord-015021-pol2qm74 5864 28 consecutively consecutively RB cord-015021-pol2qm74 5864 29 admitted admit VBN cord-015021-pol2qm74 5864 30 to to IN cord-015021-pol2qm74 5864 31 t t NN cord-015021-pol2qm74 5864 32 ~ ~ CD cord-015021-pol2qm74 5864 33 MICH MICH NNP cord-015021-pol2qm74 5864 34 . . . cord-015021-pol2qm74 5865 1 Criteria criterion NNS cord-015021-pol2qm74 5865 2 for for IN cord-015021-pol2qm74 5865 3 chronic chronic JJ cord-015021-pol2qm74 5865 4 disease disease NN cord-015021-pol2qm74 5865 5 , , , cord-015021-pol2qm74 5865 6 sepsis sepsis NN cord-015021-pol2qm74 5865 7 , , , cord-015021-pol2qm74 5865 8 OSFsi.e osfsi.e CD cord-015021-pol2qm74 5865 9 . . . cord-015021-pol2qm74 5866 1 cardiovascular cardiovascular JJ cord-015021-pol2qm74 5866 2 ( ( -LRB- cord-015021-pol2qm74 5866 3 CF CF NNP cord-015021-pol2qm74 5866 4 ) ) -RRB- cord-015021-pol2qm74 5866 5 , , , cord-015021-pol2qm74 5866 6 pulmonary pulmonary JJ cord-015021-pol2qm74 5866 7 ( ( -LRB- cord-015021-pol2qm74 5866 8 PF PF NNP cord-015021-pol2qm74 5866 9 ) ) -RRB- cord-015021-pol2qm74 5866 10 , , , cord-015021-pol2qm74 5866 11 renal renal JJ cord-015021-pol2qm74 5866 12 ( ( -LRB- cord-015021-pol2qm74 5866 13 RF RF NNP cord-015021-pol2qm74 5866 14 ) ) -RRB- cord-015021-pol2qm74 5866 15 , , , cord-015021-pol2qm74 5866 16 neurological neurological JJ cord-015021-pol2qm74 5866 17 ( ( -LRB- cord-015021-pol2qm74 5866 18 NF NF NNP cord-015021-pol2qm74 5866 19 ) ) -RRB- cord-015021-pol2qm74 5866 20 , , , cord-015021-pol2qm74 5866 21 haematological haematological FW cord-015021-pol2qm74 5866 22 ( ( -LRB- cord-015021-pol2qm74 5866 23 HF HF NNP cord-015021-pol2qm74 5866 24 ) ) -RRB- cord-015021-pol2qm74 5866 25 , , , cord-015021-pol2qm74 5866 26 hepatic hepatic JJ cord-015021-pol2qm74 5866 27 ( ( -LRB- cord-015021-pol2qm74 5866 28 LF LF NNP cord-015021-pol2qm74 5866 29 ) ) -RRB- cord-015021-pol2qm74 5866 30 , , , cord-015021-pol2qm74 5866 31 and and CC cord-015021-pol2qm74 5866 32 gastrointestinal gastrointestinal JJ cord-015021-pol2qm74 5866 33 failure failure NN cord-015021-pol2qm74 5866 34 ( ( -LRB- cord-015021-pol2qm74 5866 35 GF)-were gf)-were CD cord-015021-pol2qm74 5866 36 derived derive VBN cord-015021-pol2qm74 5866 37 from from IN cord-015021-pol2qm74 5866 38 the the DT cord-015021-pol2qm74 5866 39 literature literature NN cord-015021-pol2qm74 5866 40 . . . cord-015021-pol2qm74 5867 1 Results result NNS cord-015021-pol2qm74 5867 2 : : : cord-015021-pol2qm74 5868 1 Patients patient NNS cord-015021-pol2qm74 5868 2 from from IN cord-015021-pol2qm74 5868 3 the the DT cord-015021-pol2qm74 5868 4 SICU SICU NNP cord-015021-pol2qm74 5868 5 and and CC cord-015021-pol2qm74 5868 6 ~ ~ NFP cord-015021-pol2qm74 5868 7 CU CU NNP cord-015021-pol2qm74 5868 8 were be VBD cord-015021-pol2qm74 5868 9 similar similar JJ cord-015021-pol2qm74 5868 10 in in IN cord-015021-pol2qm74 5868 11 age age NN cord-015021-pol2qm74 5868 12 , , , cord-015021-pol2qm74 5868 13 number number NN cord-015021-pol2qm74 5868 14 of of IN cord-015021-pol2qm74 5868 15 OSF OSF NNP cord-015021-pol2qm74 5868 16 , , , cord-015021-pol2qm74 5868 17 and and CC cord-015021-pol2qm74 5868 18 length length NN cord-015021-pol2qm74 5868 19 of of IN cord-015021-pol2qm74 5868 20 stay stay NN cord-015021-pol2qm74 5868 21 . . . cord-015021-pol2qm74 5869 1 However however RB cord-015021-pol2qm74 5869 2 , , , cord-015021-pol2qm74 5869 3 when when WRB cord-015021-pol2qm74 5869 4 compared compare VBN cord-015021-pol2qm74 5869 5 to to IN cord-015021-pol2qm74 5869 6 SICU SICU NNP cord-015021-pol2qm74 5869 7 patients patient NNS cord-015021-pol2qm74 5869 8 , , , cord-015021-pol2qm74 5869 9 MICU MICU NNP cord-015021-pol2qm74 5869 10 patients patient NNS cord-015021-pol2qm74 5869 11 had have VBD cord-015021-pol2qm74 5869 12 more more JJR cord-015021-pol2qm74 5869 13 CF cf NN cord-015021-pol2qm74 5869 14 ( ( -LRB- cord-015021-pol2qm74 5869 15 p p NN cord-015021-pol2qm74 5869 16 < < XX cord-015021-pol2qm74 5869 17 O.O1 O.O1 NNP cord-015021-pol2qm74 5869 18 ) ) -RRB- cord-015021-pol2qm74 5869 19 , , , cord-015021-pol2qm74 5869 20 sepsis sepsis NN cord-015021-pol2qm74 5869 21 ( ( -LRB- cord-015021-pol2qm74 5869 22 p p NN cord-015021-pol2qm74 5869 23 < < XX cord-015021-pol2qm74 5869 24 O.O01 O.O01 NNP cord-015021-pol2qm74 5869 25 ) ) -RRB- cord-015021-pol2qm74 5869 26 , , , cord-015021-pol2qm74 5869 27 and and CC cord-015021-pol2qm74 5869 28 mortality mortality NN cord-015021-pol2qm74 5869 29 rate rate NN cord-015021-pol2qm74 5869 30 ( ( -LRB- cord-015021-pol2qm74 5869 31 27 27 CD cord-015021-pol2qm74 5869 32 % % NN cord-015021-pol2qm74 5869 33 vs. vs. IN cord-015021-pol2qm74 5869 34 ii~ ii~ NNP cord-015021-pol2qm74 5869 35 , , , cord-015021-pol2qm74 5869 36 p p NN cord-015021-pol2qm74 5869 37 < < XX cord-015021-pol2qm74 5869 38 O.OOl o.ool XX cord-015021-pol2qm74 5869 39 ) ) -RRB- cord-015021-pol2qm74 5869 40 . . . cord-015021-pol2qm74 5870 1 In in IN cord-015021-pol2qm74 5870 2 contrast contrast NN cord-015021-pol2qm74 5870 3 , , , cord-015021-pol2qm74 5870 4 SICU SICU NNP cord-015021-pol2qm74 5870 5 patients patient NNS cord-015021-pol2qm74 5870 6 had have VBD cord-015021-pol2qm74 5870 7 more more JJR cord-015021-pol2qm74 5870 8 HP HP NNP cord-015021-pol2qm74 5870 9 and and CC cord-015021-pol2qm74 5870 10 NF nf NN cord-015021-pol2qm74 5870 11 , , , cord-015021-pol2qm74 5870 12 and and CC cord-015021-pol2qm74 5870 13 prior prior JJ cord-015021-pol2qm74 5870 14 chronic chronic JJ cord-015021-pol2qm74 5870 15 disease disease NN cord-015021-pol2qm74 5870 16 ( ( -LRB- cord-015021-pol2qm74 5870 17 all all DT cord-015021-pol2qm74 5870 18 , , , cord-015021-pol2qm74 5870 19 p p NN cord-015021-pol2qm74 5870 20 < < XX cord-015021-pol2qm74 5870 21 O.O01 o.o01 NN cord-015021-pol2qm74 5870 22 ) ) -RRB- cord-015021-pol2qm74 5870 23 . . . cord-015021-pol2qm74 5871 1 Of of IN cord-015021-pol2qm74 5871 2 the the DT cord-015021-pol2qm74 5871 3 total total JJ cord-015021-pol2qm74 5871 4 group group NN cord-015021-pol2qm74 5871 5 of of IN cord-015021-pol2qm74 5871 6 1,025 1,025 CD cord-015021-pol2qm74 5871 7 patients patient NNS cord-015021-pol2qm74 5871 8 , , , cord-015021-pol2qm74 5871 9 there there EX cord-015021-pol2qm74 5871 10 were be VBD cord-015021-pol2qm74 5871 11 406 406 CD cord-015021-pol2qm74 5871 12 ( ( -LRB- cord-015021-pol2qm74 5871 13 40 40 CD cord-015021-pol2qm74 5871 14 % % NN cord-015021-pol2qm74 5871 15 ) ) -RRB- cord-015021-pol2qm74 5871 16 patients patient NNS cord-015021-pol2qm74 5871 17 65 65 CD cord-015021-pol2qm74 5871 18 years year NNS cord-015021-pol2qm74 5871 19 of of IN cord-015021-pol2qm74 5871 20 age age NN cord-015021-pol2qm74 5871 21 or or CC cord-015021-pol2qm74 5871 22 older old JJR cord-015021-pol2qm74 5871 23 . . . cord-015021-pol2qm74 5872 1 Elderly elderly JJ cord-015021-pol2qm74 5872 2 and and CC cord-015021-pol2qm74 5872 3 younger young JJR cord-015021-pol2qm74 5872 4 patients patient NNS cord-015021-pol2qm74 5872 5 had have VBD cord-015021-pol2qm74 5872 6 comparable comparable JJ cord-015021-pol2qm74 5872 7 length length NN cord-015021-pol2qm74 5872 8 of of IN cord-015021-pol2qm74 5872 9 stay stay NN cord-015021-pol2qm74 5872 10 in in IN cord-015021-pol2qm74 5872 11 the the DT cord-015021-pol2qm74 5872 12 ICJ ICJ NNP cord-015021-pol2qm74 5872 13 , , , cord-015021-pol2qm74 5872 14 but but CC cord-015021-pol2qm74 5872 15 elderly elderly JJ cord-015021-pol2qm74 5872 16 patients patient NNS cord-015021-pol2qm74 5872 17 had have VBD cord-015021-pol2qm74 5872 18 significantly significantly RB cord-015021-pol2qm74 5872 19 more more RBR cord-015021-pol2qm74 5872 20 chronic chronic JJ cord-015021-pol2qm74 5872 21 disease disease NN cord-015021-pol2qm74 5872 22 , , , cord-015021-pol2qm74 5872 23 sepsis sepsis NN cord-015021-pol2qm74 5872 24 , , , cord-015021-pol2qm74 5872 25 and and CC cord-015021-pol2qm74 5872 26 number number NN cord-015021-pol2qm74 5872 27 of of IN cord-015021-pol2qm74 5872 28 OSF OSF NNP cord-015021-pol2qm74 5872 29 ( ( -LRB- cord-015021-pol2qm74 5872 30 all all DT cord-015021-pol2qm74 5872 31 , , , cord-015021-pol2qm74 5872 32 p p NN cord-015021-pol2qm74 5872 33 < < XX cord-015021-pol2qm74 5872 34 O.O02 O.O02 NNP cord-015021-pol2qm74 5872 35 ) ) -RRB- cord-015021-pol2qm74 5872 36 . . . cord-015021-pol2qm74 5873 1 All all DT cord-015021-pol2qm74 5873 2 OSFs osf NNS cord-015021-pol2qm74 5873 3 , , , cord-015021-pol2qm74 5873 4 except except IN cord-015021-pol2qm74 5873 5 HF HF NNP cord-015021-pol2qm74 5873 6 and and CC cord-015021-pol2qm74 5873 7 NF NF NNP cord-015021-pol2qm74 5873 8 , , , cord-015021-pol2qm74 5873 9 were be VBD cord-015021-pol2qm74 5873 10 more more JJR cord-015021-pol2qm74 5874 1 ~o~ ~o~ . cord-015021-pol2qm74 5875 1 mon mon NNP cord-015021-pol2qm74 5875 2 i~ i~ NNP cord-015021-pol2qm74 5875 3 mdeLjl mdeLjl NNP cord-015021-pol2qm74 5875 4 , , , cord-015021-pol2qm74 5875 5 eompard eompard NN cord-015021-pol2qm74 5875 6 to to IN cord-015021-pol2qm74 5875 7 you -PRON- PRP cord-015021-pol2qm74 5875 8 - - HYPH cord-015021-pol2qm74 5875 9 ger ger JJ cord-015021-pol2qm74 5875 10 patients patient NNS cord-015021-pol2qm74 5875 11 . . . cord-015021-pol2qm74 5876 1 ~he ~he JJ cord-015021-pol2qm74 5876 2 mortality mortality NN cord-015021-pol2qm74 5876 3 is be VBZ cord-015021-pol2qm74 5876 4 also also RB cord-015021-pol2qm74 5876 5 higher high JJR cord-015021-pol2qm74 5876 6 in in IN cord-015021-pol2qm74 5876 7 elderly elderly JJ cord-015021-pol2qm74 5876 8 patients patient NNS cord-015021-pol2qm74 5876 9 ( ( -LRB- cord-015021-pol2qm74 5876 10 29 29 CD cord-015021-pol2qm74 5876 11 % % NN cord-015021-pol2qm74 5876 12 vs. vs. IN cord-015021-pol2qm74 5876 13 11 11 CD cord-015021-pol2qm74 5876 14 % % NN cord-015021-pol2qm74 5876 15 in in IN cord-015021-pol2qm74 5876 16 younger young JJR cord-015021-pol2qm74 5876 17 patients patient NNS cord-015021-pol2qm74 5876 18 ) ) -RRB- cord-015021-pol2qm74 5876 19 . . . cord-015021-pol2qm74 5877 1 After after IN cord-015021-pol2qm74 5877 2 multiple multiple JJ cord-015021-pol2qm74 5877 3 logistic logistic JJ cord-015021-pol2qm74 5877 4 regression regression NN cord-015021-pol2qm74 5877 5 , , , cord-015021-pol2qm74 5877 6 only only JJ cord-015021-pol2qm74 5877 7 number number NN cord-015021-pol2qm74 5877 8 of of IN cord-015021-pol2qm74 5877 9 OSF OSF NNP cord-015021-pol2qm74 5877 10 increased increase VBN cord-015021-pol2qm74 5877 11 mortality mortality NN cord-015021-pol2qm74 5877 12 by by IN cord-015021-pol2qm74 5877 13 a a DT cord-015021-pol2qm74 5877 14 factor factor NN cord-015021-pol2qm74 5877 15 of of IN cord-015021-pol2qm74 5877 16 2.48 2.48 CD cord-015021-pol2qm74 5877 17 ( ( -LRB- cord-015021-pol2qm74 5877 18 95 95 CD cord-015021-pol2qm74 5877 19 % % NN cord-015021-pol2qm74 5877 20 confidence confidence NN cord-015021-pol2qm74 5877 21 limits limit NNS cord-015021-pol2qm74 5877 22 , , , cord-015021-pol2qm74 5877 23 1.97 1.97 CD cord-015021-pol2qm74 5877 24 - - SYM cord-015021-pol2qm74 5877 25 3.12 3.12 CD cord-015021-pol2qm74 5877 26 ) ) -RRB- cord-015021-pol2qm74 5877 27 , , , cord-015021-pol2qm74 5877 28 age age NN cord-015021-pol2qm74 5877 29 did do VBD cord-015021-pol2qm74 5877 30 not not RB cord-015021-pol2qm74 5877 31 increased increase VBN cord-015021-pol2qm74 5877 32 [ [ -LRB- cord-015021-pol2qm74 5877 33 odds odd NNS cord-015021-pol2qm74 5877 34 ratio ratio NN cord-015021-pol2qm74 5877 35 1.05 1.05 CD cord-015021-pol2qm74 5877 36 ( ( -LRB- cord-015021-pol2qm74 5877 37 i.01i.i0 i.01i.i0 NN cord-015021-pol2qm74 5877 38 ) ) -RRB- cord-015021-pol2qm74 5877 39 ] ] -RRB- cord-015021-pol2qm74 5877 40 , , , cord-015021-pol2qm74 5877 41 while while IN cord-015021-pol2qm74 5877 42 admission admission NN cord-015021-pol2qm74 5877 43 to to IN cord-015021-pol2qm74 5877 44 the the DT cord-015021-pol2qm74 5877 45 SICU SICU NNP cord-015021-pol2qm74 5877 46 reduced reduce VBN cord-015021-pol2qm74 5877 47 risk risk NN cord-015021-pol2qm74 5877 48 of of IN cord-015021-pol2qm74 5877 49 death death NN cord-015021-pol2qm74 5877 50 by by IN cord-015021-pol2qm74 5877 51 a a DT cord-015021-pol2qm74 5877 52 factor factor NN cord-015021-pol2qm74 5877 53 of of IN cord-015021-pol2qm74 5877 54 0.15 0.15 CD cord-015021-pol2qm74 5877 55 ( ( -LRB- cord-015021-pol2qm74 5877 56 0.08 0.08 CD cord-015021-pol2qm74 5877 57 - - SYM cord-015021-pol2qm74 5877 58 0.30 0.30 CD cord-015021-pol2qm74 5877 59 ) ) -RRB- cord-015021-pol2qm74 5877 60 . . . cord-015021-pol2qm74 5878 1 Conclusions conclusion NNS cord-015021-pol2qm74 5878 2 : : : cord-015021-pol2qm74 5879 1 Based base VBN cord-015021-pol2qm74 5879 2 on on IN cord-015021-pol2qm74 5879 3 these these DT cord-015021-pol2qm74 5879 4 results result NNS cord-015021-pol2qm74 5879 5 , , , cord-015021-pol2qm74 5879 6 we -PRON- PRP cord-015021-pol2qm74 5879 7 conclude conclude VBP cord-015021-pol2qm74 5879 8 that that IN cord-015021-pol2qm74 5879 9 age age NN cord-015021-pol2qm74 5879 10 does do VBZ cord-015021-pol2qm74 5879 11 not not RB cord-015021-pol2qm74 5879 12 have have VB cord-015021-pol2qm74 5879 13 any any DT cord-015021-pol2qm74 5879 14 impact impact NN cord-015021-pol2qm74 5879 15 on on IN cord-015021-pol2qm74 5879 16 ICU ICU NNP cord-015021-pol2qm74 5879 17 outcome outcome NN cord-015021-pol2qm74 5879 18 in in IN cord-015021-pol2qm74 5879 19 the the DT cord-015021-pol2qm74 5879 20 elderly elderly JJ cord-015021-pol2qm74 5879 21 . . . cord-015021-pol2qm74 5880 1 The the DT cord-015021-pol2qm74 5880 2 only only JJ cord-015021-pol2qm74 5880 3 prognostic prognostic JJ cord-015021-pol2qm74 5880 4 factor factor NN cord-015021-pol2qm74 5880 5 is be VBZ cord-015021-pol2qm74 5880 6 the the DT cord-015021-pol2qm74 5880 7 extent extent NN cord-015021-pol2qm74 5880 8 of of IN cord-015021-pol2qm74 5880 9 acute acute JJ cord-015021-pol2qm74 5880 10 disease disease NN cord-015021-pol2qm74 5880 11 , , , cord-015021-pol2qm74 5880 12 as as IN cord-015021-pol2qm74 5880 13 measured measure VBN cord-015021-pol2qm74 5880 14 by by IN cord-015021-pol2qm74 5880 15 the the DT cord-015021-pol2qm74 5880 16 number number NN cord-015021-pol2qm74 5880 17 of of IN cord-015021-pol2qm74 5880 18 OSF OSF NNP cord-015021-pol2qm74 5880 19 . . . cord-015021-pol2qm74 5881 1 Hence hence RB cord-015021-pol2qm74 5881 2 , , , cord-015021-pol2qm74 5881 3 prevention prevention NN cord-015021-pol2qm74 5881 4 of of IN cord-015021-pol2qm74 5881 5 OaF oaf NN cord-015021-pol2qm74 5881 6 may may MD cord-015021-pol2qm74 5881 7 influence influence VB cord-015021-pol2qm74 5881 8 outcome outcome NN cord-015021-pol2qm74 5881 9 in in IN cord-015021-pol2qm74 5881 10 elderly elderly JJ cord-015021-pol2qm74 5881 11 patients patient NNS cord-015021-pol2qm74 5881 12 with with IN cord-015021-pol2qm74 5881 13 critical critical JJ cord-015021-pol2qm74 5881 14 illness illness NN cord-015021-pol2qm74 5881 15 . . . cord-015021-pol2qm74 5882 1 The the DT cord-015021-pol2qm74 5882 2 lower low JJR cord-015021-pol2qm74 5882 3 risk risk NN cord-015021-pol2qm74 5882 4 of of IN cord-015021-pol2qm74 5882 5 death death NN cord-015021-pol2qm74 5882 6 in in IN cord-015021-pol2qm74 5882 7 SICUpatients sicupatient NNS cord-015021-pol2qm74 5882 8 may may MD cord-015021-pol2qm74 5882 9 be be VB cord-015021-pol2qm74 5882 10 explained explain VBN cord-015021-pol2qm74 5882 11 by by IN cord-015021-pol2qm74 5882 12 the the DT cord-015021-pol2qm74 5882 13 large large JJ cord-015021-pol2qm74 5882 14 proportion proportion NN cord-015021-pol2qm74 5882 15 of of IN cord-015021-pol2qm74 5882 16 postoperative postoperative JJ cord-015021-pol2qm74 5882 17 elective elective JJ cord-015021-pol2qm74 5882 18 patients patient NNS cord-015021-pol2qm74 5882 19 with with IN cord-015021-pol2qm74 5882 20 relative relative JJ cord-015021-pol2qm74 5882 21 mild mild JJ cord-015021-pol2qm74 5882 22 chronic chronic JJ cord-015021-pol2qm74 5882 23 disease disease NN cord-015021-pol2qm74 5882 24 , , , cord-015021-pol2qm74 5882 25 and and CC cord-015021-pol2qm74 5882 26 the the DT cord-015021-pol2qm74 5882 27 lower low JJR cord-015021-pol2qm74 5882 28 incidence incidence NN cord-015021-pol2qm74 5882 29 of of IN cord-015021-pol2qm74 5882 30 sepsis sepsis NN cord-015021-pol2qm74 5882 31 . . . cord-015021-pol2qm74 5883 1 Department Department NNP cord-015021-pol2qm74 5883 2 of of IN cord-015021-pol2qm74 5883 3 Surgery Surgery NNP cord-015021-pol2qm74 5883 4 , , , cord-015021-pol2qm74 5883 5 Free Free NNP cord-015021-pol2qm74 5883 6 University University NNP cord-015021-pol2qm74 5883 7 Hospital Hospital NNP cord-015021-pol2qm74 5883 8 , , , cord-015021-pol2qm74 5883 9 De De NNP cord-015021-pol2qm74 5883 10 Boelelaan Boelelaan NNP cord-015021-pol2qm74 5883 11 1117 1117 CD cord-015021-pol2qm74 5883 12 , , , cord-015021-pol2qm74 5883 13 1081 1081 CD cord-015021-pol2qm74 5883 14 ~V ~V . cord-015021-pol2qm74 5883 15 Amsterdam Amsterdam NNP cord-015021-pol2qm74 5883 16 , , , cord-015021-pol2qm74 5883 17 The the DT cord-015021-pol2qm74 5883 18 Netherlands Netherlands NNP cord-015021-pol2qm74 5883 19 . . . cord-015021-pol2qm74 5884 1 SEPTIC septic JJ cord-015021-pol2qm74 5884 2 SHOCK shock NN cord-015021-pol2qm74 5884 3 AND and CC cord-015021-pol2qm74 5884 4 LOW low JJ cord-015021-pol2qm74 5884 5 OUTPUT output NN cord-015021-pol2qm74 5884 6 SYNDROME syndrome NN cord-015021-pol2qm74 5885 1 H.Miyakawa H.Miyakawa NNP cord-015021-pol2qm74 5885 2 , , , cord-015021-pol2qm74 5885 3 T.Noguchi T.Noguchi NNP cord-015021-pol2qm74 5885 4 , , , cord-015021-pol2qm74 5885 5 S.Hattori S.Hattori NNP cord-015021-pol2qm74 5885 6 , , , cord-015021-pol2qm74 5885 7 A. a. NN cord-015021-pol2qm74 5885 8 Mizutani Mizutani NNP cord-015021-pol2qm74 5885 9 , , , cord-015021-pol2qm74 5885 10 M. M. NNP cord-015021-pol2qm74 5885 11 Mori Mori NNP cord-015021-pol2qm74 5885 12 and and CC cord-015021-pol2qm74 5885 13 N.Honda N.Honda NNP cord-015021-pol2qm74 5885 14 Objectives Objectives NNPS cord-015021-pol2qm74 5885 15 : : : cord-015021-pol2qm74 5885 16 Cytckines cytckine NNS cord-015021-pol2qm74 5885 17 are be VBP cord-015021-pol2qm74 5885 18 thought think VBN cord-015021-pol2qm74 5885 19 to to TO cord-015021-pol2qm74 5885 20 cause cause VB cord-015021-pol2qm74 5885 21 the the DT cord-015021-pol2qm74 5885 22 acute acute JJ cord-015021-pol2qm74 5885 23 phase phase NN cord-015021-pol2qm74 5885 24 reactions reaction NNS cord-015021-pol2qm74 5885 25 under under IN cord-015021-pol2qm74 5885 26 several several JJ cord-015021-pol2qm74 5885 27 critical critical JJ cord-015021-pol2qm74 5885 28 conditions condition NNS cord-015021-pol2qm74 5885 29 . . . cord-015021-pol2qm74 5886 1 We -PRON- PRP cord-015021-pol2qm74 5886 2 had have VBD cord-015021-pol2qm74 5886 3 investigated investigate VBN cord-015021-pol2qm74 5886 4 the the DT cord-015021-pol2qm74 5886 5 relationships relationship NNS cord-015021-pol2qm74 5886 6 between between IN cord-015021-pol2qm74 5886 7 cytokines cytokine NNS cord-015021-pol2qm74 5886 8 network network NN cord-015021-pol2qm74 5886 9 which which WDT cord-015021-pol2qm74 5886 10 included include VBD cord-015021-pol2qm74 5886 11 IL-6,1L-8,ACTH IL-6,1L-8,ACTH NNP cord-015021-pol2qm74 5886 12 and and CC cord-015021-pol2qm74 5886 13 cortisol cortisol NN cord-015021-pol2qm74 5886 14 , , , cord-015021-pol2qm74 5886 15 and and CC cord-015021-pol2qm74 5886 16 the the DT cord-015021-pol2qm74 5886 17 outcome outcome NN cord-015021-pol2qm74 5886 18 of of IN cord-015021-pol2qm74 5886 19 the the DT cord-015021-pol2qm74 5886 20 patients patient NNS cord-015021-pol2qm74 5886 21 with with IN cord-015021-pol2qm74 5886 22 septic septic JJ cord-015021-pol2qm74 5886 23 shock shock NN cord-015021-pol2qm74 5886 24 or or CC cord-015021-pol2qm74 5886 25 low low JJ cord-015021-pol2qm74 5886 26 output output NN cord-015021-pol2qm74 5886 27 syndrome syndrome NN cord-015021-pol2qm74 5886 28 ( ( -LRB- cord-015021-pol2qm74 5886 29 LOS LOS NNP cord-015021-pol2qm74 5886 30 ) ) -RRB- cord-015021-pol2qm74 5886 31 . . . cord-015021-pol2qm74 5887 1 Materials material NNS cord-015021-pol2qm74 5887 2 and and CC cord-015021-pol2qm74 5887 3 methods method NNS cord-015021-pol2qm74 5887 4 : : : cord-015021-pol2qm74 5887 5 In in IN cord-015021-pol2qm74 5887 6 the the DT cord-015021-pol2qm74 5887 7 septic septic JJ cord-015021-pol2qm74 5887 8 group group NN cord-015021-pol2qm74 5887 9 and and CC cord-015021-pol2qm74 5887 10 LOS LOS NNP cord-015021-pol2qm74 5887 11 group group NN cord-015021-pol2qm74 5887 12 , , , cord-015021-pol2qm74 5887 13 nine nine CD cord-015021-pol2qm74 5887 14 and and CC cord-015021-pol2qm74 5887 15 four four CD cord-015021-pol2qm74 5887 16 patients patient NNS cord-015021-pol2qm74 5887 17 were be VBD cord-015021-pol2qm74 5887 18 enrolled enrol VBN cord-015021-pol2qm74 5887 19 respectively respectively RB cord-015021-pol2qm74 5887 20 . . . cord-015021-pol2qm74 5888 1 Furthermore furthermore RB cord-015021-pol2qm74 5888 2 , , , cord-015021-pol2qm74 5888 3 the the DT cord-015021-pol2qm74 5888 4 patients patient NNS cord-015021-pol2qm74 5888 5 in in IN cord-015021-pol2qm74 5888 6 the the DT cord-015021-pol2qm74 5888 7 septic septic JJ cord-015021-pol2qm74 5888 8 group group NN cord-015021-pol2qm74 5888 9 were be VBD cord-015021-pol2qm74 5888 10 divided divide VBN cord-015021-pol2qm74 5888 11 into into IN cord-015021-pol2qm74 5888 12 two two CD cord-015021-pol2qm74 5888 13 groups group NNS cord-015021-pol2qm74 5888 14 , , , cord-015021-pol2qm74 5888 15 survival survival NN cord-015021-pol2qm74 5888 16 ( ( -LRB- cord-015021-pol2qm74 5888 17 n=5 n=5 NNP cord-015021-pol2qm74 5888 18 ) ) -RRB- cord-015021-pol2qm74 5888 19 and and CC cord-015021-pol2qm74 5888 20 non non JJ cord-015021-pol2qm74 5888 21 - - JJ cord-015021-pol2qm74 5888 22 survival survival JJ cord-015021-pol2qm74 5888 23 group group NN cord-015021-pol2qm74 5889 1 ( ( -LRB- cord-015021-pol2qm74 5889 2 n=4).tn n=4).tn ADD cord-015021-pol2qm74 5890 1 these these DT cord-015021-pol2qm74 5890 2 patients patient NNS cord-015021-pol2qm74 5890 3 , , , cord-015021-pol2qm74 5890 4 lL-6,1L-8,ACTH lL-6,1L-8,ACTH NNP cord-015021-pol2qm74 5890 5 and and CC cord-015021-pol2qm74 5890 6 cortisol cortisol NN cord-015021-pol2qm74 5890 7 had have VBD cord-015021-pol2qm74 5890 8 been be VBN cord-015021-pol2qm74 5890 9 measured measure VBN cord-015021-pol2qm74 5890 10 every every DT cord-015021-pol2qm74 5890 11 day day NN cord-015021-pol2qm74 5890 12 after after IN cord-015021-pol2qm74 5890 13 diagnosis diagnosis NN cord-015021-pol2qm74 5890 14 of of IN cord-015021-pol2qm74 5890 15 septic septic JJ cord-015021-pol2qm74 5890 16 shock shock NN cord-015021-pol2qm74 5890 17 or or CC cord-015021-pol2qm74 5891 1 LOS.The LOS.The NNP cord-015021-pol2qm74 5891 2 total total JJ cord-015021-pol2qm74 5891 3 number number NN cord-015021-pol2qm74 5891 4 of of IN cord-015021-pol2qm74 5891 5 measurements measurement NNS cord-015021-pol2qm74 5891 6 were be VBD cord-015021-pol2qm74 5891 7 12 12 CD cord-015021-pol2qm74 5891 8 points point NNS cord-015021-pol2qm74 5891 9 in in IN cord-015021-pol2qm74 5891 10 survival survival NN cord-015021-pol2qm74 5891 11 septic septic NN cord-015021-pol2qm74 5891 12 group group NN cord-015021-pol2qm74 5891 13 , , , cord-015021-pol2qm74 5892 1 l l NNP cord-015021-pol2qm74 5892 2 l l NNP cord-015021-pol2qm74 5892 3 points point NNS cord-015021-pol2qm74 5892 4 in in IN cord-015021-pol2qm74 5892 5 non non JJ cord-015021-pol2qm74 5892 6 - - JJ cord-015021-pol2qm74 5892 7 survival survival JJ cord-015021-pol2qm74 5892 8 septic septic JJ cord-015021-pol2qm74 5892 9 group group NN cord-015021-pol2qm74 5892 10 and and CC cord-015021-pol2qm74 5892 11 10 10 CD cord-015021-pol2qm74 5892 12 points point NNS cord-015021-pol2qm74 5892 13 in in IN cord-015021-pol2qm74 5892 14 LOS LOS NNP cord-015021-pol2qm74 5892 15 group group NN cord-015021-pol2qm74 5892 16 . . . cord-015021-pol2qm74 5893 1 Statistical statistical JJ cord-015021-pol2qm74 5893 2 analysis analysis NN cord-015021-pol2qm74 5893 3 was be VBD cord-015021-pol2qm74 5893 4 used use VBN cord-015021-pol2qm74 5893 5 student student NN cord-015021-pol2qm74 5893 6 's 's POS cord-015021-pol2qm74 5893 7 t t NN cord-015021-pol2qm74 5893 8 - - HYPH cord-015021-pol2qm74 5893 9 test test NN cord-015021-pol2qm74 5893 10 to to TO cord-015021-pol2qm74 5893 11 compare compare VB cord-015021-pol2qm74 5893 12 the the DT cord-015021-pol2qm74 5893 13 mean mean NN cord-015021-pol2qm74 5893 14 of of IN cord-015021-pol2qm74 5893 15 each each DT cord-015021-pol2qm74 5893 16 group group NN cord-015021-pol2qm74 5893 17 , , , cord-015021-pol2qm74 5893 18 and and CC cord-015021-pol2qm74 5893 19 the the DT cord-015021-pol2qm74 5893 20 changes change NNS cord-015021-pol2qm74 5893 21 were be VBD cord-015021-pol2qm74 5893 22 reported report VBN cord-015021-pol2qm74 5893 23 as as IN cord-015021-pol2qm74 5893 24 clinicat clinicat RB cord-015021-pol2qm74 5893 25 significant significant JJ cord-015021-pol2qm74 5893 26 if if IN cord-015021-pol2qm74 5893 27 P<0.05 P<0.05 NNP cord-015021-pol2qm74 5893 28 . . . cord-015021-pol2qm74 5894 1 Results result NNS cord-015021-pol2qm74 5894 2 : : : cord-015021-pol2qm74 5895 1 IL-8 IL-8 NNP cord-015021-pol2qm74 5895 2 levels level NNS cord-015021-pol2qm74 5895 3 in in IN cord-015021-pol2qm74 5895 4 non non JJ cord-015021-pol2qm74 5895 5 - - JJ cord-015021-pol2qm74 5895 6 survival survival JJ cord-015021-pol2qm74 5895 7 septic septic JJ cord-015021-pol2qm74 5895 8 group group NN cord-015021-pol2qm74 5895 9 were be VBD cord-015021-pol2qm74 5895 10 higher high JJR cord-015021-pol2qm74 5895 11 than than IN cord-015021-pol2qm74 5895 12 in in IN cord-015021-pol2qm74 5895 13 both both DT cord-015021-pol2qm74 5895 14 survival survival NN cord-015021-pol2qm74 5895 15 septic septic NN cord-015021-pol2qm74 5895 16 and and CC cord-015021-pol2qm74 5895 17 LOS LOS NNP cord-015021-pol2qm74 5895 18 group.lL-6 group.ll-6 JJ cord-015021-pol2qm74 5895 19 levels level NNS cord-015021-pol2qm74 5895 20 in in IN cord-015021-pol2qm74 5895 21 non non JJ cord-015021-pol2qm74 5895 22 - - JJ cord-015021-pol2qm74 5895 23 survival survival JJ cord-015021-pol2qm74 5895 24 septic septic JJ cord-015021-pol2qm74 5895 25 group group NN cord-015021-pol2qm74 5895 26 were be VBD cord-015021-pol2qm74 5895 27 more more RBR cord-015021-pol2qm74 5895 28 significant significant JJ cord-015021-pol2qm74 5895 29 than than IN cord-015021-pol2qm74 5895 30 in in IN cord-015021-pol2qm74 5895 31 both both DT cord-015021-pol2qm74 5895 32 survival survival NN cord-015021-pol2qm74 5895 33 and and CC cord-015021-pol2qm74 5895 34 LOS LOS NNP cord-015021-pol2qm74 5895 35 group group NN cord-015021-pol2qm74 5895 36 . . . cord-015021-pol2qm74 5896 1 Otherwise otherwise RB cord-015021-pol2qm74 5896 2 , , , cord-015021-pol2qm74 5896 3 there there EX cord-015021-pol2qm74 5896 4 were be VBD cord-015021-pol2qm74 5896 5 no no DT cord-015021-pol2qm74 5896 6 differences difference NNS cord-015021-pol2qm74 5896 7 with with IN cord-015021-pol2qm74 5896 8 respect respect NN cord-015021-pol2qm74 5896 9 to to IN cord-015021-pol2qm74 5896 10 ACTH ACTH NNP cord-015021-pol2qm74 5896 11 and and CC cord-015021-pol2qm74 5896 12 cortisol cortisol NN cord-015021-pol2qm74 5896 13 among among IN cord-015021-pol2qm74 5896 14 three three CD cord-015021-pol2qm74 5896 15 groups group NNS cord-015021-pol2qm74 5896 16 . . . cord-015021-pol2qm74 5897 1 Conclusions conclusion NNS cord-015021-pol2qm74 5897 2 : : : cord-015021-pol2qm74 5898 1 We -PRON- PRP cord-015021-pol2qm74 5898 2 assumed assume VBD cord-015021-pol2qm74 5898 3 that that IN cord-015021-pol2qm74 5898 4 LOS LOS NNP cord-015021-pol2qm74 5898 5 would would MD cord-015021-pol2qm74 5898 6 make make VB cord-015021-pol2qm74 5898 7 several several JJ cord-015021-pol2qm74 5898 8 organs organ NNS cord-015021-pol2qm74 5898 9 dysfunction dysfunction NN cord-015021-pol2qm74 5898 10 as as RB cord-015021-pol2qm74 5898 11 well well RB cord-015021-pol2qm74 5898 12 as as IN cord-015021-pol2qm74 5898 13 septic septic JJ cord-015021-pol2qm74 5898 14 shock shock NN cord-015021-pol2qm74 5898 15 . . . cord-015021-pol2qm74 5899 1 But but CC cord-015021-pol2qm74 5899 2 our -PRON- PRP$ cord-015021-pol2qm74 5899 3 results result NNS cord-015021-pol2qm74 5899 4 showed show VBD cord-015021-pol2qm74 5899 5 septic septic JJ cord-015021-pol2qm74 5899 6 shock shock NN cord-015021-pol2qm74 5899 7 , , , cord-015021-pol2qm74 5899 8 especially especially RB cord-015021-pol2qm74 5899 9 non non JJ cord-015021-pol2qm74 5899 10 - - JJ cord-015021-pol2qm74 5899 11 survival survival JJ cord-015021-pol2qm74 5899 12 , , , cord-015021-pol2qm74 5899 13 had have VBD cord-015021-pol2qm74 5899 14 different different JJ cord-015021-pol2qm74 5899 15 cytokins cytokins NNP cord-015021-pol2qm74 5899 16 network network NN cord-015021-pol2qm74 5899 17 mechanism mechanism NN cord-015021-pol2qm74 5899 18 for for IN cord-015021-pol2qm74 5899 19 organs organ NNS cord-015021-pol2qm74 5899 20 failure failure NN cord-015021-pol2qm74 5899 21 from from IN cord-015021-pol2qm74 5899 22 LOS LOS NNP cord-015021-pol2qm74 5899 23 . . . cord-015021-pol2qm74 5900 1 Lasson Lasson NNP cord-015021-pol2qm74 5900 2 , , , cord-015021-pol2qm74 5900 3 ~ ~ NFP cord-015021-pol2qm74 5900 4 , , , cord-015021-pol2qm74 5900 5 G/3ransson G/3ransson NNP cord-015021-pol2qm74 5900 6 J J NNP cord-015021-pol2qm74 5900 7 , , , cord-015021-pol2qm74 5900 8 JiJnsson JiJnsson NNP cord-015021-pol2qm74 5900 9 K. K. NNP cord-015021-pol2qm74 5900 10 Eady Eady NNP cord-015021-pol2qm74 5901 1 diagnosis diagnosis NN cord-015021-pol2qm74 5901 2 of of IN cord-015021-pol2qm74 5901 3 complications complication NNS cord-015021-pol2qm74 5901 4 after after IN cord-015021-pol2qm74 5901 5 trauma trauma NN cord-015021-pol2qm74 5901 6 is be VBZ cord-015021-pol2qm74 5901 7 imperative imperative JJ cord-015021-pol2qm74 5901 8 to to TO cord-015021-pol2qm74 5901 9 decrease decrease VB cord-015021-pol2qm74 5901 10 morbidity morbidity NN cord-015021-pol2qm74 5901 11 and and CC cord-015021-pol2qm74 5901 12 mortality mortality NN cord-015021-pol2qm74 5901 13 . . . cord-015021-pol2qm74 5902 1 For for IN cord-015021-pol2qm74 5902 2 this this DT cord-015021-pol2qm74 5902 3 purpose purpose NN cord-015021-pol2qm74 5902 4 an an DT cord-015021-pol2qm74 5902 5 easy easy JJ cord-015021-pol2qm74 5902 6 , , , cord-015021-pol2qm74 5902 7 cheap cheap JJ cord-015021-pol2qm74 5902 8 and and CC cord-015021-pol2qm74 5902 9 fast fast JJ cord-015021-pol2qm74 5902 10 diagnostic diagnostic JJ cord-015021-pol2qm74 5902 11 method method NN cord-015021-pol2qm74 5902 12 is be VBZ cord-015021-pol2qm74 5902 13 needed need VBN cord-015021-pol2qm74 5902 14 . . . cord-015021-pol2qm74 5903 1 The the DT cord-015021-pol2qm74 5903 2 aim aim NN cord-015021-pol2qm74 5903 3 of of IN cord-015021-pol2qm74 5903 4 this this DT cord-015021-pol2qm74 5903 5 study study NN cord-015021-pol2qm74 5903 6 was be VBD cord-015021-pol2qm74 5903 7 to to TO cord-015021-pol2qm74 5903 8 analyse analyse VB cord-015021-pol2qm74 5903 9 if if IN cord-015021-pol2qm74 5903 10 complications complication NNS cord-015021-pol2qm74 5903 11 after after IN cord-015021-pol2qm74 5903 12 surgical surgical JJ cord-015021-pol2qm74 5903 13 trauma trauma NN cord-015021-pol2qm74 5903 14 of of IN cord-015021-pol2qm74 5903 15 various various JJ cord-015021-pol2qm74 5903 16 extent extent NN cord-015021-pol2qm74 5903 17 could could MD cord-015021-pol2qm74 5903 18 be be VB cord-015021-pol2qm74 5903 19 diagnosed diagnose VBN cord-015021-pol2qm74 5903 20 earlier early RBR cord-015021-pol2qm74 5903 21 using use VBG cord-015021-pol2qm74 5903 22 preoperative preoperative JJ cord-015021-pol2qm74 5903 23 or or CC cord-015021-pol2qm74 5903 24 daily daily JJ cord-015021-pol2qm74 5903 25 postoperative postoperative JJ cord-015021-pol2qm74 5903 26 measurements measurement NNS cord-015021-pol2qm74 5903 27 of of IN cord-015021-pol2qm74 5903 28 various various JJ cord-015021-pol2qm74 5903 29 plasma plasma NN cord-015021-pol2qm74 5903 30 proteins protein NNS cord-015021-pol2qm74 5903 31 than than IN cord-015021-pol2qm74 5903 32 by by IN cord-015021-pol2qm74 5903 33 using use VBG cord-015021-pol2qm74 5903 34 climcal climcal JJ cord-015021-pol2qm74 5903 35 signs sign NNS cord-015021-pol2qm74 5903 36 of of IN cord-015021-pol2qm74 5903 37 complications complication NNS cord-015021-pol2qm74 5903 38 . . . cord-015021-pol2qm74 5904 1 Material material NN cord-015021-pol2qm74 5904 2 and and CC cord-015021-pol2qm74 5904 3 Methods method NNS cord-015021-pol2qm74 5904 4 : : : cord-015021-pol2qm74 5904 5 Two two CD cord-015021-pol2qm74 5904 6 acute acute JJ cord-015021-pol2qm74 5904 7 phase phase NN cord-015021-pol2qm74 5904 8 proteins protein NNS cord-015021-pol2qm74 5904 9 ( ( -LRB- cord-015021-pol2qm74 5904 10 C c NN cord-015021-pol2qm74 5904 11 - - HYPH cord-015021-pol2qm74 5904 12 reactive reactive JJ cord-015021-pol2qm74 5904 13 protein protein NN cord-015021-pol2qm74 5904 14 and and CC cord-015021-pol2qm74 5904 15 antichymotrypsin antichymotrypsin NNP cord-015021-pol2qm74 5904 16 ) ) -RRB- cord-015021-pol2qm74 5904 17 , , , cord-015021-pol2qm74 5904 18 lbur lbur NNP cord-015021-pol2qm74 5905 1 main main JJ cord-015021-pol2qm74 5905 2 plasma plasma NN cord-015021-pol2qm74 5905 3 protease protease NN cord-015021-pol2qm74 5905 4 inhibitors inhibitor NNS cord-015021-pol2qm74 5905 5 ( ( -LRB- cord-015021-pol2qm74 5905 6 alpha-2-maeroglobulin alpha-2-maeroglobulin NNP cord-015021-pol2qm74 5905 7 , , , cord-015021-pol2qm74 5905 8 C C NNP cord-015021-pol2qm74 5905 9 1estemse 1estemse CD cord-015021-pol2qm74 5905 10 inhibitor inhibitor NN cord-015021-pol2qm74 5905 11 , , , cord-015021-pol2qm74 5905 12 antithrombin antithrombin NN cord-015021-pol2qm74 5905 13 Ill Ill NNP cord-015021-pol2qm74 5905 14 and and CC cord-015021-pol2qm74 5905 15 alpha-2-antiplasmin alpha-2-antiplasmin NNP cord-015021-pol2qm74 5905 16 ) ) -RRB- cord-015021-pol2qm74 5905 17 and and CC cord-015021-pol2qm74 5905 18 one one CD cord-015021-pol2qm74 5905 19 collagen collagen NN cord-015021-pol2qm74 5905 20 precursor precursor NN cord-015021-pol2qm74 5905 21 ( ( -LRB- cord-015021-pol2qm74 5905 22 procollagen procollagen NNP cord-015021-pol2qm74 5905 23 III III NNP cord-015021-pol2qm74 5905 24 peptide peptide NN cord-015021-pol2qm74 5905 25 ) ) -RRB- cord-015021-pol2qm74 5905 26 were be VBD cord-015021-pol2qm74 5905 27 measured measure VBN cord-015021-pol2qm74 5905 28 preoperatively preoperatively RB cord-015021-pol2qm74 5905 29 and and CC cord-015021-pol2qm74 5905 30 then then RB cord-015021-pol2qm74 5905 31 once once RB cord-015021-pol2qm74 5905 32 dally dally VBP cord-015021-pol2qm74 5905 33 for for IN cord-015021-pol2qm74 5905 34 7 7 CD cord-015021-pol2qm74 5905 35 days day NNS cord-015021-pol2qm74 5905 36 postoperatively postoperatively RB cord-015021-pol2qm74 5905 37 . . . cord-015021-pol2qm74 5906 1 For for IN cord-015021-pol2qm74 5906 2 the the DT cord-015021-pol2qm74 5906 3 plasma plasma NN cord-015021-pol2qm74 5906 4 protease protease NN cord-015021-pol2qm74 5906 5 inhibitors inhibitor NNS cord-015021-pol2qm74 5906 6 immunorcactive immunorcactive JJ cord-015021-pol2qm74 5906 7 as as RB cord-015021-pol2qm74 5906 8 well well RB cord-015021-pol2qm74 5906 9 as as IN cord-015021-pol2qm74 5906 10 functional functional JJ cord-015021-pol2qm74 5906 11 levels level NNS cord-015021-pol2qm74 5906 12 were be VBD cord-015021-pol2qm74 5906 13 measured measure VBN cord-015021-pol2qm74 5906 14 . . . cord-015021-pol2qm74 5907 1 Haemoglbin Haemoglbin NNP cord-015021-pol2qm74 5907 2 , , , cord-015021-pol2qm74 5907 3 albumin albumin NN cord-015021-pol2qm74 5907 4 and and CC cord-015021-pol2qm74 5907 5 the the DT cord-015021-pol2qm74 5907 6 white white JJ cord-015021-pol2qm74 5907 7 blood blood NN cord-015021-pol2qm74 5907 8 cell cell NN cord-015021-pol2qm74 5907 9 count count NN cord-015021-pol2qm74 5907 10 were be VBD cord-015021-pol2qm74 5907 11 also also RB cord-015021-pol2qm74 5907 12 measured measure VBN cord-015021-pol2qm74 5907 13 . . . cord-015021-pol2qm74 5908 1 Measurements measurement NNS cord-015021-pol2qm74 5908 2 were be VBD cord-015021-pol2qm74 5908 3 done do VBN cord-015021-pol2qm74 5908 4 preoperatively preoperatively NN cord-015021-pol2qm74 5908 5 in in IN cord-015021-pol2qm74 5908 6 256 256 CD cord-015021-pol2qm74 5908 7 patients patient NNS cord-015021-pol2qm74 5908 8 and and CC cord-015021-pol2qm74 5908 9 continued continue VBD cord-015021-pol2qm74 5908 10 postoperatively postoperatively RB cord-015021-pol2qm74 5908 11 in in IN cord-015021-pol2qm74 5908 12 78 78 CD cord-015021-pol2qm74 5908 13 patients patient NNS cord-015021-pol2qm74 5908 14 , , , cord-015021-pol2qm74 5908 15 70 70 CD cord-015021-pol2qm74 5908 16 % % NN cord-015021-pol2qm74 5908 17 of of IN cord-015021-pol2qm74 5908 18 the the DT cord-015021-pol2qm74 5908 19 patients patient NNS cord-015021-pol2qm74 5908 20 were be VBD cord-015021-pol2qm74 5908 21 operated operate VBN cord-015021-pol2qm74 5908 22 on on IN cord-015021-pol2qm74 5908 23 for for IN cord-015021-pol2qm74 5908 24 malignancy malignancy NN cord-015021-pol2qm74 5908 25 . . . cord-015021-pol2qm74 5909 1 Resulls resull NNS cord-015021-pol2qm74 5909 2 : : : cord-015021-pol2qm74 5910 1 Preoperative Preoperative NNP cord-015021-pol2qm74 5910 2 plasma plasma NN cord-015021-pol2qm74 5910 3 C c NN cord-015021-pol2qm74 5910 4 - - HYPH cord-015021-pol2qm74 5910 5 reactive reactive JJ cord-015021-pol2qm74 5910 6 protein protein NN cord-015021-pol2qm74 5910 7 levels level NNS cord-015021-pol2qm74 5910 8 were be VBD cord-015021-pol2qm74 5910 9 higher high JJR cord-015021-pol2qm74 5910 10 in in IN cord-015021-pol2qm74 5910 11 patients patient NNS cord-015021-pol2qm74 5910 12 developing develop VBG cord-015021-pol2qm74 5910 13 postoperative postoperative JJ cord-015021-pol2qm74 5910 14 complications complication NNS cord-015021-pol2qm74 5910 15 . . . cord-015021-pol2qm74 5911 1 This this DT cord-015021-pol2qm74 5911 2 discrimination discrimination NN cord-015021-pol2qm74 5911 3 increased increase VBD cord-015021-pol2qm74 5911 4 when when WRB cord-015021-pol2qm74 5911 5 plasma plasma NN cord-015021-pol2qm74 5911 6 was be VBD cord-015021-pol2qm74 5911 7 sequentially sequentially RB cord-015021-pol2qm74 5911 8 analysed analyse VBN cord-015021-pol2qm74 5911 9 postoperatively postoperatively RB cord-015021-pol2qm74 5911 10 , , , cord-015021-pol2qm74 5911 11 when when WRB cord-015021-pol2qm74 5911 12 a a DT cord-015021-pol2qm74 5911 13 remaining remain VBG cord-015021-pol2qm74 5911 14 high high JJ cord-015021-pol2qm74 5911 15 level level NN cord-015021-pol2qm74 5911 16 ora ora NN cord-015021-pol2qm74 5911 17 second second JJ cord-015021-pol2qm74 5911 18 increase increase NN cord-015021-pol2qm74 5911 19 in in IN cord-015021-pol2qm74 5911 20 plasma plasma NN cord-015021-pol2qm74 5911 21 levels level NNS cord-015021-pol2qm74 5911 22 depicted depict VBD cord-015021-pol2qm74 5911 23 a a DT cord-015021-pol2qm74 5911 24 complication complication NN cord-015021-pol2qm74 5911 25 1 1 CD cord-015021-pol2qm74 5911 26 - - SYM cord-015021-pol2qm74 5911 27 3 3 CD cord-015021-pol2qm74 5911 28 days day NNS cord-015021-pol2qm74 5911 29 earlier early RBR cord-015021-pol2qm74 5911 30 than than IN cord-015021-pol2qm74 5911 31 clinical clinical JJ cord-015021-pol2qm74 5911 32 signs sign NNS cord-015021-pol2qm74 5911 33 . . . cord-015021-pol2qm74 5912 1 High high JJ cord-015021-pol2qm74 5912 2 levels level NNS cord-015021-pol2qm74 5912 3 were be VBD cord-015021-pol2qm74 5912 4 seen see VBN cord-015021-pol2qm74 5912 5 both both CC cord-015021-pol2qm74 5912 6 in in IN cord-015021-pol2qm74 5912 7 patients patient NNS cord-015021-pol2qm74 5912 8 developing develop VBG cord-015021-pol2qm74 5912 9 local local JJ cord-015021-pol2qm74 5912 10 as as RB cord-015021-pol2qm74 5912 11 well well RB cord-015021-pol2qm74 5912 12 as as IN cord-015021-pol2qm74 5912 13 in in IN cord-015021-pol2qm74 5912 14 patients patient NNS cord-015021-pol2qm74 5912 15 developing develop VBG cord-015021-pol2qm74 5912 16 general general JJ cord-015021-pol2qm74 5912 17 complications complication NNS cord-015021-pol2qm74 5912 18 . . . cord-015021-pol2qm74 5913 1 There there EX cord-015021-pol2qm74 5913 2 was be VBD cord-015021-pol2qm74 5913 3 no no DT cord-015021-pol2qm74 5913 4 clear clear JJ cord-015021-pol2qm74 5913 5 correlation correlation NN cord-015021-pol2qm74 5913 6 between between IN cord-015021-pol2qm74 5913 7 plasma plasma NN cord-015021-pol2qm74 5913 8 protease protease NN cord-015021-pol2qm74 5913 9 inhibitory inhibitory JJ cord-015021-pol2qm74 5913 10 levels level NNS cord-015021-pol2qm74 5913 11 and and CC cord-015021-pol2qm74 5913 12 complications complication NNS cord-015021-pol2qm74 5913 13 , , , cord-015021-pol2qm74 5913 14 neither neither CC cord-015021-pol2qm74 5913 15 pre pre VB cord-015021-pol2qm74 5913 16 - - : cord-015021-pol2qm74 5913 17 nor nor CC cord-015021-pol2qm74 5913 18 postoperatively postoperatively RB cord-015021-pol2qm74 5913 19 . . . cord-015021-pol2qm74 5914 1 Procollagen Procollagen NNP cord-015021-pol2qm74 5914 2 III III NNP cord-015021-pol2qm74 5914 3 paptide paptide NN cord-015021-pol2qm74 5914 4 levels level NNS cord-015021-pol2qm74 5914 5 were be VBD cord-015021-pol2qm74 5914 6 slightly slightly RB cord-015021-pol2qm74 5914 7 ( ( -LRB- cord-015021-pol2qm74 5914 8 but but CC cord-015021-pol2qm74 5914 9 not not RB cord-015021-pol2qm74 5914 10 significantly significantly RB cord-015021-pol2qm74 5914 11 ) ) -RRB- cord-015021-pol2qm74 5914 12 higher high JJR cord-015021-pol2qm74 5914 13 postoperatively postoperatively RB cord-015021-pol2qm74 5914 14 in in IN cord-015021-pol2qm74 5914 15 patients patient NNS cord-015021-pol2qm74 5914 16 developing develop VBG cord-015021-pol2qm74 5914 17 complications complication NNS cord-015021-pol2qm74 5914 18 . . . cord-015021-pol2qm74 5915 1 Contusions contusion NNS cord-015021-pol2qm74 5915 2 : : : cord-015021-pol2qm74 5916 1 The the DT cord-015021-pol2qm74 5916 2 acute acute JJ cord-015021-pol2qm74 5916 3 phase phase NN cord-015021-pol2qm74 5916 4 response response NN cord-015021-pol2qm74 5916 5 , , , cord-015021-pol2qm74 5916 6 especially especially RB cord-015021-pol2qm74 5916 7 concerning concern VBG cord-015021-pol2qm74 5916 8 C c NN cord-015021-pol2qm74 5916 9 - - HYPH cord-015021-pol2qm74 5916 10 reactive reactive JJ cord-015021-pol2qm74 5916 11 protein protein NN cord-015021-pol2qm74 5916 12 , , , cord-015021-pol2qm74 5916 13 predicts predict VBZ cord-015021-pol2qm74 5916 14 postoperative postoperative JJ cord-015021-pol2qm74 5916 15 complications complication NNS cord-015021-pol2qm74 5916 16 better well RBR cord-015021-pol2qm74 5916 17 than than IN cord-015021-pol2qm74 5916 18 both both CC cord-015021-pol2qm74 5916 19 plasma plasma NN cord-015021-pol2qm74 5916 20 protease protease NN cord-015021-pol2qm74 5916 21 inhibitors inhibitor NNS cord-015021-pol2qm74 5916 22 or or CC cord-015021-pol2qm74 5916 23 collagen collagen NN cord-015021-pol2qm74 5916 24 precursors precursor NNS cord-015021-pol2qm74 5916 25 . . . cord-015021-pol2qm74 5917 1 Preoperative Preoperative NNP cord-015021-pol2qm74 5917 2 plasma plasma NN cord-015021-pol2qm74 5917 3 C c NN cord-015021-pol2qm74 5917 4 - - HYPH cord-015021-pol2qm74 5917 5 reactive reactive JJ cord-015021-pol2qm74 5917 6 protein protein NN cord-015021-pol2qm74 5917 7 levels level NNS cord-015021-pol2qm74 5917 8 indicate indicate VBP cord-015021-pol2qm74 5917 9 the the DT cord-015021-pol2qm74 5917 10 risk risk NN cord-015021-pol2qm74 5917 11 of of IN cord-015021-pol2qm74 5917 12 postoperative postoperative JJ cord-015021-pol2qm74 5917 13 complications complication NNS cord-015021-pol2qm74 5917 14 , , , cord-015021-pol2qm74 5917 15 while while IN cord-015021-pol2qm74 5917 16 daily daily JJ cord-015021-pol2qm74 5917 17 postoperative postoperative JJ cord-015021-pol2qm74 5917 18 measurements measurement NNS cord-015021-pol2qm74 5917 19 more more RBR cord-015021-pol2qm74 5917 20 readily readily RB cord-015021-pol2qm74 5917 21 depicts depict VBZ cord-015021-pol2qm74 5917 22 a a DT cord-015021-pol2qm74 5917 23 complication complication NN cord-015021-pol2qm74 5917 24 , , , cord-015021-pol2qm74 5917 25 usually usually RB cord-015021-pol2qm74 5917 26 preceeding preceede VBG cord-015021-pol2qm74 5917 27 the the DT cord-015021-pol2qm74 5917 28 clinical clinical JJ cord-015021-pol2qm74 5917 29 signs sign NNS cord-015021-pol2qm74 5917 30 of of IN cord-015021-pol2qm74 5917 31 complication complication NN cord-015021-pol2qm74 5917 32 by by IN cord-015021-pol2qm74 5917 33 1 1 CD cord-015021-pol2qm74 5917 34 - - SYM cord-015021-pol2qm74 5917 35 3 3 CD cord-015021-pol2qm74 5917 36 days day NNS cord-015021-pol2qm74 5917 37 . . . cord-015021-pol2qm74 5918 1 Dept Dept NNP cord-015021-pol2qm74 5918 2 . . . cord-015021-pol2qm74 5919 1 of of IN cord-015021-pol2qm74 5919 2 Surgery Surgery NNP cord-015021-pol2qm74 5919 3 M'alm6 M'alm6 NNP cord-015021-pol2qm74 5919 4 General General NNP cord-015021-pol2qm74 5919 5 Hospital Hospital NNP cord-015021-pol2qm74 5919 6 , , , cord-015021-pol2qm74 5919 7 S-2 S-2 NNP cord-015021-pol2qm74 5919 8 I4 I4 NNP cord-015021-pol2qm74 5919 9 01 01 CD cord-015021-pol2qm74 5919 10 Malmr Malmr NNP cord-015021-pol2qm74 5919 11 , , , cord-015021-pol2qm74 5919 12 Sweden Sweden NNP cord-015021-pol2qm74 5919 13 . . . cord-015021-pol2qm74 5920 1 MOF MOF NNP cord-015021-pol2qm74 5920 2 is be VBZ cord-015021-pol2qm74 5920 3 a a DT cord-015021-pol2qm74 5920 4 major major JJ cord-015021-pol2qm74 5920 5 threat threat NN cord-015021-pol2qm74 5920 6 to to IN cord-015021-pol2qm74 5920 7 the the DT cord-015021-pol2qm74 5920 8 extensive extensive JJ cord-015021-pol2qm74 5920 9 burned burn VBN cord-015021-pol2qm74 5920 10 patients patient NNS cord-015021-pol2qm74 5920 11 and and CC cord-015021-pol2qm74 5920 12 associated associate VBN cord-015021-pol2qm74 5920 13 with with IN cord-015021-pol2qm74 5920 14 a a DT cord-015021-pol2qm74 5920 15 high high JJ cord-015021-pol2qm74 5920 16 mortality mortality NN cord-015021-pol2qm74 5920 17 rate rate NN cord-015021-pol2qm74 5920 18 . . . cord-015021-pol2qm74 5921 1 The the DT cord-015021-pol2qm74 5921 2 role role NN cord-015021-pol2qm74 5921 3 of of IN cord-015021-pol2qm74 5921 4 endotoxemia endotoxemia NN cord-015021-pol2qm74 5921 5 in in IN cord-015021-pol2qm74 5921 6 the the DT cord-015021-pol2qm74 5921 7 pathogenesis pathogenesis NN cord-015021-pol2qm74 5921 8 of of IN cord-015021-pol2qm74 5921 9 MOF MOF NNP cord-015021-pol2qm74 5921 10 in in IN cord-015021-pol2qm74 5921 11 burned burn VBN cord-015021-pol2qm74 5921 12 patients patient NNS cord-015021-pol2qm74 5921 13 remains remain VBZ cord-015021-pol2qm74 5921 14 controversial controversial JJ cord-015021-pol2qm74 5921 15 . . . cord-015021-pol2qm74 5922 1 In in IN cord-015021-pol2qm74 5922 2 this this DT cord-015021-pol2qm74 5922 3 study study NN cord-015021-pol2qm74 5922 4 , , , cord-015021-pol2qm74 5922 5 We -PRON- PRP cord-015021-pol2qm74 5922 6 examined examine VBD cord-015021-pol2qm74 5922 7 the the DT cord-015021-pol2qm74 5922 8 relationship relationship NN cord-015021-pol2qm74 5922 9 of of IN cord-015021-pol2qm74 5922 10 plasma plasma NN cord-015021-pol2qm74 5922 11 endotoxin endotoxin NN cord-015021-pol2qm74 5922 12 levels level NNS cord-015021-pol2qm74 5922 13 to to IN cord-015021-pol2qm74 5922 14 development development NN cord-015021-pol2qm74 5922 15 of of IN cord-015021-pol2qm74 5922 16 MOF MOF NNP cord-015021-pol2qm74 5922 17 , , , cord-015021-pol2qm74 5922 18 and and CC cord-015021-pol2qm74 5922 19 outcome outcome NN cord-015021-pol2qm74 5922 20 in in IN cord-015021-pol2qm74 5922 21 patients patient NNS cord-015021-pol2qm74 5922 22 with with IN cord-015021-pol2qm74 5922 23 thermal thermal JJ cord-015021-pol2qm74 5922 24 injury injury NN cord-015021-pol2qm74 5922 25 . . . cord-015021-pol2qm74 5923 1 Methods method NNS cord-015021-pol2qm74 5923 2 : : : cord-015021-pol2qm74 5924 1 A a DT cord-015021-pol2qm74 5924 2 prospective prospective JJ cord-015021-pol2qm74 5924 3 cohort cohort NN cord-015021-pol2qm74 5924 4 study study NN cord-015021-pol2qm74 5924 5 of of IN cord-015021-pol2qm74 5924 6 17 17 CD cord-015021-pol2qm74 5924 7 patients patient NNS cord-015021-pol2qm74 5924 8 admitted admit VBN cord-015021-pol2qm74 5924 9 with with IN cord-015021-pol2qm74 5924 10 burns burn NNS cord-015021-pol2qm74 5924 11 covering cover VBG cord-015021-pol2qm74 5924 12 more more JJR cord-015021-pol2qm74 5924 13 than than IN cord-015021-pol2qm74 5924 14 70 70 CD cord-015021-pol2qm74 5924 15 per per IN cord-015021-pol2qm74 5924 16 cent cent NN cord-015021-pol2qm74 5924 17 of of IN cord-015021-pol2qm74 5924 18 body body NN cord-015021-pol2qm74 5924 19 surface surface NN cord-015021-pol2qm74 5924 20 area area NN cord-015021-pol2qm74 5924 21 was be VBD cord-015021-pol2qm74 5924 22 undertaken undertake VBN cord-015021-pol2qm74 5924 23 . . . cord-015021-pol2qm74 5925 1 Circulating circulate VBG cord-015021-pol2qm74 5925 2 endotoxin endotoxin NN cord-015021-pol2qm74 5925 3 concentrations concentration NNS cord-015021-pol2qm74 5925 4 were be VBD cord-015021-pol2qm74 5925 5 measured measure VBN cord-015021-pol2qm74 5925 6 by by IN cord-015021-pol2qm74 5925 7 modified modify VBN cord-015021-pol2qm74 5925 8 limulus limulus NNP cord-015021-pol2qm74 5925 9 amebocyte amebocyte NNP cord-015021-pol2qm74 5925 10 lysate lysate NN cord-015021-pol2qm74 5925 11 assay assay NN cord-015021-pol2qm74 5925 12 in in IN cord-015021-pol2qm74 5925 13 serial serial JJ cord-015021-pol2qm74 5925 14 samples sample NNS cord-015021-pol2qm74 5925 15 of of IN cord-015021-pol2qm74 5925 16 plasma plasma NN cord-015021-pol2qm74 5925 17 . . . cord-015021-pol2qm74 5926 1 Results result NNS cord-015021-pol2qm74 5926 2 : : : cord-015021-pol2qm74 5926 3 7 7 CD cord-015021-pol2qm74 5926 4 out out IN cord-015021-pol2qm74 5926 5 of of IN cord-015021-pol2qm74 5926 6 17 17 CD cord-015021-pol2qm74 5926 7 burned burn VBN cord-015021-pol2qm74 5926 8 patients patient NNS cord-015021-pol2qm74 5926 9 developed develop VBD cord-015021-pol2qm74 5926 10 MOF MOF NNP cord-015021-pol2qm74 5926 11 according accord VBG cord-015021-pol2qm74 5926 12 to to IN cord-015021-pol2qm74 5926 13 multiple multiple JJ cord-015021-pol2qm74 5926 14 criteria criterion NNS cord-015021-pol2qm74 5926 15 . . . cord-015021-pol2qm74 5927 1 The the DT cord-015021-pol2qm74 5927 2 plasma plasma NN cord-015021-pol2qm74 5927 3 endotoxin endotoxin NN cord-015021-pol2qm74 5927 4 concentrations concentration NNS cord-015021-pol2qm74 5927 5 of of IN cord-015021-pol2qm74 5927 6 patients patient NNS cord-015021-pol2qm74 5927 7 with with IN cord-015021-pol2qm74 5927 8 MOF MOF NNP cord-015021-pol2qm74 5927 9 were be VBD cord-015021-pol2qm74 5927 10 0.512 0.512 CD cord-015021-pol2qm74 5927 11 - - HYPH cord-015021-pol2qm74 5927 12 -1.127 -1.127 NNP cord-015021-pol2qm74 5927 13 EU EU NNP cord-015021-pol2qm74 5927 14 / / SYM cord-015021-pol2qm74 5927 15 ml ml NNS cord-015021-pol2qm74 5927 16 , , , cord-015021-pol2qm74 5927 17 significantly significantly RB cord-015021-pol2qm74 5927 18 higher high JJR cord-015021-pol2qm74 5927 19 than than IN cord-015021-pol2qm74 5927 20 that that DT cord-015021-pol2qm74 5927 21 of of IN cord-015021-pol2qm74 5927 22 10 10 CD cord-015021-pol2qm74 5927 23 patients patient NNS cord-015021-pol2qm74 5927 24 without without IN cord-015021-pol2qm74 5927 25 MOF MOF NNP cord-015021-pol2qm74 5927 26 ( ( -LRB- cord-015021-pol2qm74 5927 27 0.216 0.216 CD cord-015021-pol2qm74 5927 28 - - SYM cord-015021-pol2qm74 5927 29 0.553 0.553 CD cord-015021-pol2qm74 5927 30 EU EU NNP cord-015021-pol2qm74 5927 31 / / SYM cord-015021-pol2qm74 5927 32 ml ml NN cord-015021-pol2qm74 5927 33 ) ) -RRB- cord-015021-pol2qm74 5927 34 on on IN cord-015021-pol2qm74 5927 35 3 3 CD cord-015021-pol2qm74 5927 36 , , , cord-015021-pol2qm74 5927 37 14 14 CD cord-015021-pol2qm74 5927 38 , , , cord-015021-pol2qm74 5927 39 21 21 CD cord-015021-pol2qm74 5927 40 and and CC cord-015021-pol2qm74 5927 41 28 28 CD cord-015021-pol2qm74 5927 42 days day NNS cord-015021-pol2qm74 5927 43 postburn postburn NN cord-015021-pol2qm74 5927 44 ( ( -LRB- cord-015021-pol2qm74 5927 45 p p NN cord-015021-pol2qm74 5927 46 < < XX cord-015021-pol2qm74 5927 47 0.05 0.05 CD cord-015021-pol2qm74 5927 48 - - HYPH cord-015021-pol2qm74 5927 49 -0.01 -0.01 CD cord-015021-pol2qm74 5927 50 ) ) -RRB- cord-015021-pol2qm74 5927 51 . . . cord-015021-pol2qm74 5928 1 Significantly significantly RB cord-015021-pol2qm74 5928 2 more more JJR cord-015021-pol2qm74 5928 3 incidence incidence NN cord-015021-pol2qm74 5928 4 of of IN cord-015021-pol2qm74 5928 5 positive positive JJ cord-015021-pol2qm74 5928 6 endotoxin endotoxin NN cord-015021-pol2qm74 5928 7 test test NN cord-015021-pol2qm74 5928 8 ( ( -LRB- cord-015021-pol2qm74 5928 9 > > XX cord-015021-pol2qm74 5929 1 _ _ NN cord-015021-pol2qm74 5929 2 0.120 0.120 CD cord-015021-pol2qm74 5929 3 EU EU NNP cord-015021-pol2qm74 5929 4 / / SYM cord-015021-pol2qm74 5929 5 ml ml NN cord-015021-pol2qm74 5929 6 ) ) -RRB- cord-015021-pol2qm74 5929 7 was be VBD cord-015021-pol2qm74 5929 8 found find VBN cord-015021-pol2qm74 5929 9 in in IN cord-015021-pol2qm74 5929 10 patients patient NNS cord-015021-pol2qm74 5929 11 who who WP cord-015021-pol2qm74 5929 12 developed develop VBD cord-015021-pol2qm74 5929 13 MOF MOF NNP cord-015021-pol2qm74 5929 14 as as IN cord-015021-pol2qm74 5929 15 compared compare VBN cord-015021-pol2qm74 5929 16 to to IN cord-015021-pol2qm74 5929 17 that that DT cord-015021-pol2qm74 5929 18 of of IN cord-015021-pol2qm74 5929 19 Non Non NNP cord-015021-pol2qm74 5929 20 - - NNP cord-015021-pol2qm74 5929 21 MOF MOF NNP cord-015021-pol2qm74 5929 22 during during IN cord-015021-pol2qm74 5929 23 the the DT cord-015021-pol2qm74 5929 24 observation observation NN cord-015021-pol2qm74 5929 25 period period NN cord-015021-pol2qm74 5929 26 ( ( -LRB- cord-015021-pol2qm74 5929 27 p<0.05 p<0.05 CD cord-015021-pol2qm74 5929 28 ) ) -RRB- cord-015021-pol2qm74 5929 29 . . . cord-015021-pol2qm74 5930 1 As as IN cord-015021-pol2qm74 5930 2 the the DT cord-015021-pol2qm74 5930 3 mean mean JJ cord-015021-pol2qm74 5930 4 endotoxin endotoxin NN cord-015021-pol2qm74 5930 5 levels level NNS cord-015021-pol2qm74 5930 6 increased increase VBD cord-015021-pol2qm74 5930 7 , , , cord-015021-pol2qm74 5930 8 the the DT cord-015021-pol2qm74 5930 9 prevalence prevalence NN cord-015021-pol2qm74 5930 10 of of IN cord-015021-pol2qm74 5930 11 MOF MOF NNP cord-015021-pol2qm74 5930 12 and and CC cord-015021-pol2qm74 5930 13 death death NN cord-015021-pol2qm74 5930 14 also also RB cord-015021-pol2qm74 5930 15 increased increase VBD cord-015021-pol2qm74 5930 16 ( ( -LRB- cord-015021-pol2qm74 5930 17 see see VB cord-015021-pol2qm74 5930 18 table table NN cord-015021-pol2qm74 5930 19 below below RB cord-015021-pol2qm74 5930 20 ) ) -RRB- cord-015021-pol2qm74 5930 21 , , , cord-015021-pol2qm74 5930 22 persistent persistent JJ cord-015021-pol2qm74 5930 23 endotoxemia endotoxemia NN cord-015021-pol2qm74 5930 24 carried carry VBD cord-015021-pol2qm74 5930 25 a a DT cord-015021-pol2qm74 5930 26 poor poor JJ cord-015021-pol2qm74 5930 27 prognosis prognosis NN cord-015021-pol2qm74 5930 28 . . . cord-015021-pol2qm74 5931 1 Conclusions conclusion NNS cord-015021-pol2qm74 5931 2 : : : cord-015021-pol2qm74 5932 1 The the DT cord-015021-pol2qm74 5932 2 present present JJ cord-015021-pol2qm74 5932 3 investigation investigation NN cord-015021-pol2qm74 5932 4 provide provide VBP cord-015021-pol2qm74 5932 5 further further JJ cord-015021-pol2qm74 5932 6 evidence evidence NN cord-015021-pol2qm74 5932 7 that that IN cord-015021-pol2qm74 5932 8 endotoxemia endotoxemia NN cord-015021-pol2qm74 5932 9 in in IN cord-015021-pol2qm74 5932 10 severely severely RB cord-015021-pol2qm74 5932 11 burned burn VBN cord-015021-pol2qm74 5932 12 patients patient NNS cord-015021-pol2qm74 5932 13 commonly commonly RB cord-015021-pol2qm74 5932 14 occur occur VBP cord-015021-pol2qm74 5932 15 . . . cord-015021-pol2qm74 5933 1 Cimulating Cimulating NNP cord-015021-pol2qm74 5933 2 endotoxin endotoxin NN cord-015021-pol2qm74 5933 3 has have VBZ cord-015021-pol2qm74 5933 4 also also RB cord-015021-pol2qm74 5933 5 been be VBN cord-015021-pol2qm74 5933 6 found find VBN cord-015021-pol2qm74 5933 7 to to TO cord-015021-pol2qm74 5933 8 be be VB cord-015021-pol2qm74 5933 9 strongly strongly RB cord-015021-pol2qm74 5933 10 associated associate VBN cord-015021-pol2qm74 5933 11 with with IN cord-015021-pol2qm74 5933 12 development development NN cord-015021-pol2qm74 5933 13 of of IN cord-015021-pol2qm74 5933 14 MOF MOF NNP cord-015021-pol2qm74 5933 15 and and CC cord-015021-pol2qm74 5933 16 mortality mortality NN cord-015021-pol2qm74 5933 17 following follow VBG cord-015021-pol2qm74 5933 18 major major JJ cord-015021-pol2qm74 5933 19 burn burn NN cord-015021-pol2qm74 5933 20 injury injury NN cord-015021-pol2qm74 5933 21 . . . cord-015021-pol2qm74 5934 1 Multiple multiple JJ cord-015021-pol2qm74 5934 2 hemostatic hemostatic JJ cord-015021-pol2qm74 5934 3 changes change NNS cord-015021-pol2qm74 5934 4 occur occur VBP cord-015021-pol2qm74 5934 5 in in IN cord-015021-pol2qm74 5934 6 sepsis sepsis NN cord-015021-pol2qm74 5934 7 mad mad JJ cord-015021-pol2qm74 5934 8 multiple multiple JJ cord-015021-pol2qm74 5934 9 organ organ NN cord-015021-pol2qm74 5934 10 failure failure NN cord-015021-pol2qm74 5934 11 ( ( -LRB- cord-015021-pol2qm74 5934 12 MOF MOF NNP cord-015021-pol2qm74 5934 13 ) ) -RRB- cord-015021-pol2qm74 5934 14 . . . cord-015021-pol2qm74 5935 1 To to TO cord-015021-pol2qm74 5935 2 evaluate evaluate VB cord-015021-pol2qm74 5935 3 the the DT cord-015021-pol2qm74 5935 4 role role NN cord-015021-pol2qm74 5935 5 of of IN cord-015021-pol2qm74 5935 6 platelcts platelct NNS cord-015021-pol2qm74 5935 7 in in IN cord-015021-pol2qm74 5935 8 patients patient NNS cord-015021-pol2qm74 5935 9 with with IN cord-015021-pol2qm74 5935 10 sepsis sepsis NN cord-015021-pol2qm74 5935 11 and and CC cord-015021-pol2qm74 5935 12 MOF MOF NNP cord-015021-pol2qm74 5935 13 , , , cord-015021-pol2qm74 5935 14 we -PRON- PRP cord-015021-pol2qm74 5935 15 examined examine VBD cord-015021-pol2qm74 5935 16 changes change NNS cord-015021-pol2qm74 5935 17 in in IN cord-015021-pol2qm74 5935 18 surface surface NN cord-015021-pol2qm74 5935 19 glyeoproteins glyeoprotein NNS cord-015021-pol2qm74 5935 20 on on IN cord-015021-pol2qm74 5935 21 circulating circulate VBG cord-015021-pol2qm74 5935 22 platelets platelet NNS cord-015021-pol2qm74 5935 23 of of IN cord-015021-pol2qm74 5935 24 t4 t4 NNP cord-015021-pol2qm74 5935 25 patients patient NNS cord-015021-pol2qm74 5935 26 with with IN cord-015021-pol2qm74 5935 27 suspected suspect VBN cord-015021-pol2qm74 5935 28 sepsis sepsis NN cord-015021-pol2qm74 5935 29 and and CC cord-015021-pol2qm74 5935 30 MOF MOF NNP cord-015021-pol2qm74 5935 31 . . . cord-015021-pol2qm74 5936 1 The the DT cord-015021-pol2qm74 5936 2 severity severity NN cord-015021-pol2qm74 5936 3 of of IN cord-015021-pol2qm74 5936 4 sepsis sepsis NN cord-015021-pol2qm74 5936 5 and and CC cord-015021-pol2qm74 5936 6 MOF MOF NNP cord-015021-pol2qm74 5936 7 was be VBD cord-015021-pol2qm74 5936 8 assessed assess VBN cord-015021-pol2qm74 5936 9 by by IN cord-015021-pol2qm74 5936 10 Eiebute Eiebute NNP cord-015021-pol2qm74 5936 11 and and CC cord-015021-pol2qm74 5936 12 APACHE APACHE NNP cord-015021-pol2qm74 5936 13 1I 1i CD cord-015021-pol2qm74 5936 14 scoring score VBG cord-015021-pol2qm74 5936 15 system system NN cord-015021-pol2qm74 5936 16 , , , cord-015021-pol2qm74 5936 17 respectively respectively RB cord-015021-pol2qm74 5936 18 . . . cord-015021-pol2qm74 5937 1 Using use VBG cord-015021-pol2qm74 5937 2 flow flow NN cord-015021-pol2qm74 5937 3 cytometric cytometric NN cord-015021-pol2qm74 5937 4 techniques technique NNS cord-015021-pol2qm74 5937 5 and and CC cord-015021-pol2qm74 5937 6 platelets platelet NNS cord-015021-pol2qm74 5937 7 specific specific JJ cord-015021-pol2qm74 5937 8 monoclonal monoclonal JJ cord-015021-pol2qm74 5937 9 antibodies antibody NNS cord-015021-pol2qm74 5937 10 , , , cord-015021-pol2qm74 5937 11 platelet platelet NN cord-015021-pol2qm74 5937 12 surface surface NN cord-015021-pol2qm74 5937 13 expression expression NN cord-015021-pol2qm74 5937 14 of of IN cord-015021-pol2qm74 5937 15 fibrinogen fibrinogen NN cord-015021-pol2qm74 5937 16 receptor receptor NN cord-015021-pol2qm74 5937 17 on on IN cord-015021-pol2qm74 5937 18 GPIIb GPIIb NNP cord-015021-pol2qm74 5937 19 - - HYPH cord-015021-pol2qm74 5937 20 IIIa iiia NN cord-015021-pol2qm74 5937 21 , , , cord-015021-pol2qm74 5937 22 ofvon ofvon NN cord-015021-pol2qm74 5937 23 Willebrand Willebrand NNP cord-015021-pol2qm74 5937 24 receptor receptor NN cord-015021-pol2qm74 5937 25 GPIb GPIb NNS cord-015021-pol2qm74 5937 26 , , , cord-015021-pol2qm74 5937 27 and and CC cord-015021-pol2qm74 5937 28 of of IN cord-015021-pol2qm74 5937 29 granula granula NN cord-015021-pol2qm74 5937 30 glycoproteins glycoprotein NNS cord-015021-pol2qm74 5937 31 ( ( -LRB- cord-015021-pol2qm74 5937 32 thrombospondin thrombospondin NNP cord-015021-pol2qm74 5937 33 , , , cord-015021-pol2qm74 5937 34 GMP-140 GMP-140 NNP cord-015021-pol2qm74 5937 35 , , , cord-015021-pol2qm74 5937 36 and and CC cord-015021-pol2qm74 5937 37 GP53 GP53 NNP cord-015021-pol2qm74 5937 38 ) ) -RRB- cord-015021-pol2qm74 5937 39 was be VBD cord-015021-pol2qm74 5937 40 measured measure VBN cord-015021-pol2qm74 5937 41 . . . cord-015021-pol2qm74 5938 1 Receptor receptor NN cord-015021-pol2qm74 5938 2 density density NN cord-015021-pol2qm74 5938 3 of of IN cord-015021-pol2qm74 5938 4 GPIIb GPIIb NNP cord-015021-pol2qm74 5938 5 - - HYPH cord-015021-pol2qm74 5938 6 Illa Illa NNP cord-015021-pol2qm74 5938 7 mad mad JJ cord-015021-pol2qm74 5938 8 GPIb GPIb NNS cord-015021-pol2qm74 5938 9 on on IN cord-015021-pol2qm74 5938 10 circulating circulate VBG cord-015021-pol2qm74 5938 11 platelets platelet NNS cord-015021-pol2qm74 5938 12 was be VBD cord-015021-pol2qm74 5938 13 not not RB cord-015021-pol2qm74 5938 14 affected affect VBN cord-015021-pol2qm74 5938 15 by by IN cord-015021-pol2qm74 5938 16 sepsis sepsis NN cord-015021-pol2qm74 5938 17 or or CC cord-015021-pol2qm74 5938 18 MOF MOF NNP cord-015021-pol2qm74 5938 19 . . . cord-015021-pol2qm74 5939 1 In in IN cord-015021-pol2qm74 5939 2 septic septic JJ cord-015021-pol2qm74 5939 3 patients patient NNS cord-015021-pol2qm74 5939 4 surface surface VBP cord-015021-pol2qm74 5939 5 expression expression NN cord-015021-pol2qm74 5939 6 of of IN cord-015021-pol2qm74 5939 7 activated activate VBN cord-015021-pol2qm74 5939 8 fibrinogen fibrinogen NN cord-015021-pol2qm74 5939 9 receptor receptor NN cord-015021-pol2qm74 5939 10 ( ( -LRB- cord-015021-pol2qm74 5939 11 LIBS1 libs1 JJ cord-015021-pol2qm74 5939 12 expression expression NN cord-015021-pol2qm74 5939 13 ) ) -RRB- cord-015021-pol2qm74 5939 14 was be VBD cord-015021-pol2qm74 5939 15 significantly significantly RB cord-015021-pol2qm74 5939 16 elevated elevate VBN cord-015021-pol2qm74 5939 17 ( ( -LRB- cord-015021-pol2qm74 5939 18 p<0.05 p<0.05 CD cord-015021-pol2qm74 5939 19 ) ) -RRB- cord-015021-pol2qm74 5939 20 and and CC cord-015021-pol2qm74 5939 21 correlated correlate VBN cord-015021-pol2qm74 5939 22 well well RB cord-015021-pol2qm74 5939 23 with with IN cord-015021-pol2qm74 5939 24 severity severity NN cord-015021-pol2qm74 5939 25 of of IN cord-015021-pol2qm74 5939 26 disease disease NN cord-015021-pol2qm74 5939 27 ( ( -LRB- cord-015021-pol2qm74 5939 28 F0.597 F0.597 NNP cord-015021-pol2qm74 5939 29 ) ) -RRB- cord-015021-pol2qm74 5939 30 . . . cord-015021-pol2qm74 5940 1 NO no DT cord-015021-pol2qm74 5940 2 significant significant JJ cord-015021-pol2qm74 5940 3 change change NN cord-015021-pol2qm74 5940 4 in in IN cord-015021-pol2qm74 5940 5 surface surface NN cord-015021-pol2qm74 5940 6 expression expression NN cord-015021-pol2qm74 5940 7 ofthrombospondin ofthrombospondin NNP cord-015021-pol2qm74 5940 8 , , , cord-015021-pol2qm74 5940 9 GMP-140 GMP-140 NNP cord-015021-pol2qm74 5940 10 or or CC cord-015021-pol2qm74 5940 11 GP53 GP53 NNP cord-015021-pol2qm74 5940 12 was be VBD cord-015021-pol2qm74 5940 13 noted note VBN cord-015021-pol2qm74 5940 14 in in IN cord-015021-pol2qm74 5940 15 septic septic JJ cord-015021-pol2qm74 5940 16 patients patient NNS cord-015021-pol2qm74 5940 17 . . . cord-015021-pol2qm74 5941 1 In in IN cord-015021-pol2qm74 5941 2 contrast contrast NN cord-015021-pol2qm74 5941 3 , , , cord-015021-pol2qm74 5941 4 degranulation degranulation NN cord-015021-pol2qm74 5941 5 ofgraanle ofgraanle NNS cord-015021-pol2qm74 5941 6 glycoproteins glycoprotein NNS cord-015021-pol2qm74 5941 7 was be VBD cord-015021-pol2qm74 5941 8 significantly significantly RB cord-015021-pol2qm74 5941 9 elevated elevate VBN cord-015021-pol2qm74 5941 10 in in IN cord-015021-pol2qm74 5941 11 MOF MOF NNP cord-015021-pol2qm74 5941 12 ( ( -LRB- cord-015021-pol2qm74 5941 13 ! ! . cord-015021-pol2qm74 5942 1 0<0.05 0<0.05 LS cord-015021-pol2qm74 5942 2 ) ) -RRB- cord-015021-pol2qm74 5942 3 that that WDT cord-015021-pol2qm74 5942 4 correlated correlate VBD cord-015021-pol2qm74 5942 5 well well RB cord-015021-pol2qm74 5942 6 with with IN cord-015021-pol2qm74 5942 7 severity severity NN cord-015021-pol2qm74 5942 8 of of IN cord-015021-pol2qm74 5942 9 MOF MOF NNP cord-015021-pol2qm74 5942 10 ( ( -LRB- cord-015021-pol2qm74 5942 11 GMP-140 gmp-140 XX cord-015021-pol2qm74 5942 12 , , , cord-015021-pol2qm74 5942 13 r=0.611 r=0.611 JJ cord-015021-pol2qm74 5942 14 ; ; : cord-015021-pol2qm74 5942 15 Thrombospondin Thrombospondin NNP cord-015021-pol2qm74 5942 16 , , , cord-015021-pol2qm74 5942 17 r=0.643).We r=0.643).We NNP cord-015021-pol2qm74 5942 18 speculate speculate VBP cord-015021-pol2qm74 5942 19 , , , cord-015021-pol2qm74 5942 20 that that IN cord-015021-pol2qm74 5942 21 platelets platelet NNS cord-015021-pol2qm74 5942 22 in in IN cord-015021-pol2qm74 5942 23 sepsis sepsis NN cord-015021-pol2qm74 5942 24 circulate circulate VBP cord-015021-pol2qm74 5942 25 in in IN cord-015021-pol2qm74 5942 26 a a DT cord-015021-pol2qm74 5942 27 hyperaggregable hyperaggregable NN cord-015021-pol2qm74 5942 28 ( ( -LRB- cord-015021-pol2qm74 5942 29 fibrinogen fibrinogen NN cord-015021-pol2qm74 5942 30 receptor receptor NN cord-015021-pol2qm74 5942 31 activation activation NN cord-015021-pol2qm74 5942 32 ) ) -RRB- cord-015021-pol2qm74 5942 33 but but CC cord-015021-pol2qm74 5942 34 still still RB cord-015021-pol2qm74 5942 35 reversible reversible JJ cord-015021-pol2qm74 5942 36 state state NN cord-015021-pol2qm74 5942 37 that that WDT cord-015021-pol2qm74 5942 38 results result VBZ cord-015021-pol2qm74 5942 39 in in IN cord-015021-pol2qm74 5942 40 increased increase VBN cord-015021-pol2qm74 5942 41 risk risk NN cord-015021-pol2qm74 5942 42 of of IN cord-015021-pol2qm74 5942 43 microthrombotic microthrombotic JJ cord-015021-pol2qm74 5942 44 events event NNS cord-015021-pol2qm74 5942 45 . . . cord-015021-pol2qm74 5943 1 In in IN cord-015021-pol2qm74 5943 2 the the DT cord-015021-pol2qm74 5943 3 course course NN cord-015021-pol2qm74 5943 4 of of IN cord-015021-pol2qm74 5943 5 the the DT cord-015021-pol2qm74 5943 6 disease disease NN cord-015021-pol2qm74 5943 7 , , , cord-015021-pol2qm74 5943 8 irreversible irreversible JJ cord-015021-pol2qm74 5943 9 platelet platelet NN cord-015021-pol2qm74 5943 10 degranulation degranulation NN cord-015021-pol2qm74 5943 11 might may MD cord-015021-pol2qm74 5943 12 occur occur VB cord-015021-pol2qm74 5943 13 and and CC cord-015021-pol2qm74 5943 14 may may MD cord-015021-pol2qm74 5943 15 play play VB cord-015021-pol2qm74 5943 16 an an DT cord-015021-pol2qm74 5943 17 important important JJ cord-015021-pol2qm74 5943 18 role role NN cord-015021-pol2qm74 5943 19 in in IN cord-015021-pol2qm74 5943 20 development development NN cord-015021-pol2qm74 5943 21 of of IN cord-015021-pol2qm74 5943 22 MOF MOF NNP cord-015021-pol2qm74 5943 23 . . . cord-015021-pol2qm74 5944 1 Abdominal abdominal JJ cord-015021-pol2qm74 5944 2 sepsis sepsis NN cord-015021-pol2qm74 5944 3 is be VBZ cord-015021-pol2qm74 5944 4 still still RB cord-015021-pol2qm74 5944 5 associated associate VBN cord-015021-pol2qm74 5944 6 with with IN cord-015021-pol2qm74 5944 7 high high JJ cord-015021-pol2qm74 5944 8 morbidity morbidity NN cord-015021-pol2qm74 5944 9 and and CC cord-015021-pol2qm74 5944 10 mortality mortality NN cord-015021-pol2qm74 5944 11 . . . cord-015021-pol2qm74 5945 1 The the DT cord-015021-pol2qm74 5945 2 present present JJ cord-015021-pol2qm74 5945 3 study study NN cord-015021-pol2qm74 5945 4 aimed aim VBN cord-015021-pol2qm74 5945 5 at at IN cord-015021-pol2qm74 5945 6 evaluating evaluate VBG cord-015021-pol2qm74 5945 7 patients patient NNS cord-015021-pol2qm74 5945 8 with with IN cord-015021-pol2qm74 5945 9 abdominal abdominal JJ cord-015021-pol2qm74 5945 10 sepsis sepsis NN cord-015021-pol2qm74 5945 11 treated treat VBN cord-015021-pol2qm74 5945 12 at at IN cord-015021-pol2qm74 5945 13 our -PRON- PRP$ cord-015021-pol2qm74 5945 14 surgical surgical JJ cord-015021-pol2qm74 5945 15 intensive intensive JJ cord-015021-pol2qm74 5945 16 care care NN cord-015021-pol2qm74 5945 17 unit unit NN cord-015021-pol2qm74 5945 18 during during IN cord-015021-pol2qm74 5945 19 a a DT cord-015021-pol2qm74 5945 20 10-year 10-year CD cord-015021-pol2qm74 5945 21 period period NN cord-015021-pol2qm74 5945 22 with with IN cord-015021-pol2qm74 5945 23 the the DT cord-015021-pol2qm74 5945 24 aim aim NN cord-015021-pol2qm74 5945 25 of of IN cord-015021-pol2qm74 5945 26 identifying identify VBG cord-015021-pol2qm74 5945 27 potential potential JJ cord-015021-pol2qm74 5945 28 prognostic prognostic JJ cord-015021-pol2qm74 5945 29 factors factor NNS cord-015021-pol2qm74 5945 30 , , , cord-015021-pol2qm74 5945 31 bacteriological bacteriological JJ cord-015021-pol2qm74 5945 32 cultures culture NNS cord-015021-pol2qm74 5945 33 , , , cord-015021-pol2qm74 5945 34 diagnostic diagnostic JJ cord-015021-pol2qm74 5945 35 procedures procedure NNS cord-015021-pol2qm74 5945 36 , , , cord-015021-pol2qm74 5945 37 treatment treatment NN cord-015021-pol2qm74 5945 38 and and CC cord-015021-pol2qm74 5945 39 outcome outcome NN cord-015021-pol2qm74 5945 40 . . . cord-015021-pol2qm74 5946 1 During during IN cord-015021-pol2qm74 5946 2 the the DT cord-015021-pol2qm74 5946 3 period period NN cord-015021-pol2qm74 5946 4 1983 1983 CD cord-015021-pol2qm74 5946 5 - - SYM cord-015021-pol2qm74 5946 6 1992 1992 CD cord-015021-pol2qm74 5946 7 I66 I66 NNP cord-015021-pol2qm74 5946 8 patients patient NNS cord-015021-pol2qm74 5946 9 with with IN cord-015021-pol2qm74 5946 10 abdominal abdominal JJ cord-015021-pol2qm74 5946 11 sepsis sepsis NN cord-015021-pol2qm74 5946 12 were be VBD cord-015021-pol2qm74 5946 13 treated treat VBN cord-015021-pol2qm74 5946 14 at at IN cord-015021-pol2qm74 5946 15 the the DT cord-015021-pol2qm74 5946 16 ICU ICU NNP cord-015021-pol2qm74 5946 17 at at IN cord-015021-pol2qm74 5946 18 our -PRON- PRP$ cord-015021-pol2qm74 5946 19 university university NN cord-015021-pol2qm74 5946 20 hospital hospital NN cord-015021-pol2qm74 5946 21 . . . cord-015021-pol2qm74 5947 1 60 60 CD cord-015021-pol2qm74 5947 2 patients patient NNS cord-015021-pol2qm74 5947 3 were be VBD cord-015021-pol2qm74 5947 4 women woman NNS cord-015021-pol2qm74 5947 5 and and CC cord-015021-pol2qm74 5947 6 106 106 CD cord-015021-pol2qm74 5947 7 men man NNS cord-015021-pol2qm74 5947 8 with with IN cord-015021-pol2qm74 5947 9 a a DT cord-015021-pol2qm74 5947 10 mean mean JJ cord-015021-pol2qm74 5947 11 age age NN cord-015021-pol2qm74 5947 12 of of IN cord-015021-pol2qm74 5947 13 64 64 CD cord-015021-pol2qm74 5947 14 ( ( -LRB- cord-015021-pol2qm74 5947 15 17 17 CD cord-015021-pol2qm74 5947 16 - - SYM cord-015021-pol2qm74 5947 17 101 101 CD cord-015021-pol2qm74 5947 18 ) ) -RRB- cord-015021-pol2qm74 5947 19 years year NNS cord-015021-pol2qm74 5947 20 . . . cord-015021-pol2qm74 5948 1 In in IN cord-015021-pol2qm74 5948 2 74 74 CD cord-015021-pol2qm74 5948 3 cases case NNS cord-015021-pol2qm74 5948 4 , , , cord-015021-pol2qm74 5948 5 the the DT cord-015021-pol2qm74 5948 6 abdominal abdominal JJ cord-015021-pol2qm74 5948 7 sepsis sepsis NN cord-015021-pol2qm74 5948 8 occurred occur VBD cord-015021-pol2qm74 5948 9 as as IN cord-015021-pol2qm74 5948 10 a a DT cord-015021-pol2qm74 5948 11 postoperative postoperative JJ cord-015021-pol2qm74 5948 12 complication complication NN cord-015021-pol2qm74 5948 13 . . . cord-015021-pol2qm74 5949 1 The the DT cord-015021-pol2qm74 5949 2 patients patient NNS cord-015021-pol2qm74 5949 3 were be VBD cord-015021-pol2qm74 5949 4 scored score VBN cord-015021-pol2qm74 5949 5 according accord VBG cord-015021-pol2qm74 5949 6 to to IN cord-015021-pol2qm74 5949 7 APACHE APACHE NNP cord-015021-pol2qm74 5949 8 II II NNP cord-015021-pol2qm74 5949 9 and and CC cord-015021-pol2qm74 5949 10 bacteriological bacteriological JJ cord-015021-pol2qm74 5949 11 cultures culture NNS cord-015021-pol2qm74 5949 12 and and CC cord-015021-pol2qm74 5949 13 the the DT cord-015021-pol2qm74 5949 14 occurrence occurrence NN cord-015021-pol2qm74 5949 15 of of IN cord-015021-pol2qm74 5949 16 organ organ NN cord-015021-pol2qm74 5949 17 failure failure NN cord-015021-pol2qm74 5949 18 were be VBD cord-015021-pol2qm74 5949 19 noted note VBN cord-015021-pol2qm74 5949 20 . . . cord-015021-pol2qm74 5950 1 The the DT cord-015021-pol2qm74 5950 2 patients patient NNS cord-015021-pol2qm74 5950 3 were be VBD cord-015021-pol2qm74 5950 4 hospitalized hospitalize VBN cord-015021-pol2qm74 5950 5 in in IN cord-015021-pol2qm74 5950 6 median median NN cord-015021-pol2qm74 5950 7 for for IN cord-015021-pol2qm74 5950 8 40 40 CD cord-015021-pol2qm74 5950 9 ( ( -LRB- cord-015021-pol2qm74 5950 10 -273 -273 NN cord-015021-pol2qm74 5950 11 ) ) -RRB- cord-015021-pol2qm74 5950 12 days day NNS cord-015021-pol2qm74 5950 13 out out IN cord-015021-pol2qm74 5950 14 of of IN cord-015021-pol2qm74 5950 15 which which WDT cord-015021-pol2qm74 5950 16 7 7 CD cord-015021-pol2qm74 5950 17 ( ( -LRB- cord-015021-pol2qm74 5950 18 -178 -178 RB cord-015021-pol2qm74 5950 19 ) ) -RRB- cord-015021-pol2qm74 5950 20 in in IN cord-015021-pol2qm74 5950 21 the the DT cord-015021-pol2qm74 5950 22 intensive intensive JJ cord-015021-pol2qm74 5950 23 care care NN cord-015021-pol2qm74 5950 24 unit unit NN cord-015021-pol2qm74 5950 25 . . . cord-015021-pol2qm74 5951 1 46 46 CD cord-015021-pol2qm74 5951 2 out out IN cord-015021-pol2qm74 5951 3 of of IN cord-015021-pol2qm74 5951 4 166 166 CD cord-015021-pol2qm74 5951 5 patients patient NNS cord-015021-pol2qm74 5951 6 ( ( -LRB- cord-015021-pol2qm74 5951 7 28 28 CD cord-015021-pol2qm74 5951 8 % % NN cord-015021-pol2qm74 5951 9 ) ) -RRB- cord-015021-pol2qm74 5951 10 died die VBD cord-015021-pol2qm74 5951 11 in in IN cord-015021-pol2qm74 5951 12 median median NN cord-015021-pol2qm74 5951 13 after after IN cord-015021-pol2qm74 5951 14 18 18 CD cord-015021-pol2qm74 5951 15 ( ( -LRB- cord-015021-pol2qm74 5951 16 1 1 CD cord-015021-pol2qm74 5951 17 - - SYM cord-015021-pol2qm74 5951 18 194 194 CD cord-015021-pol2qm74 5951 19 ) ) -RRB- cord-015021-pol2qm74 5951 20 days day NNS cord-015021-pol2qm74 5951 21 . . . cord-015021-pol2qm74 5952 1 The the DT cord-015021-pol2qm74 5952 2 primary primary JJ cord-015021-pol2qm74 5952 3 cause cause NN cord-015021-pol2qm74 5952 4 of of IN cord-015021-pol2qm74 5952 5 mortality mortality NN cord-015021-pol2qm74 5952 6 was be VBD cord-015021-pol2qm74 5952 7 multiple multiple JJ cord-015021-pol2qm74 5952 8 organ organ NN cord-015021-pol2qm74 5952 9 failure failure NN cord-015021-pol2qm74 5952 10 ( ( -LRB- cord-015021-pol2qm74 5952 11 38/46 38/46 CD cord-015021-pol2qm74 5952 12 ; ; : cord-015021-pol2qm74 5952 13 83 83 CD cord-015021-pol2qm74 5952 14 % % NN cord-015021-pol2qm74 5952 15 ) ) -RRB- cord-015021-pol2qm74 5952 16 . . . cord-015021-pol2qm74 5953 1 APACHE APACHE NNP cord-015021-pol2qm74 5953 2 II II NNP cord-015021-pol2qm74 5953 3 scoring scoring NN cord-015021-pol2qm74 5953 4 could could MD cord-015021-pol2qm74 5953 5 not not RB cord-015021-pol2qm74 5953 6 predict predict VB cord-015021-pol2qm74 5953 7 a a DT cord-015021-pol2qm74 5953 8 fatal fatal JJ cord-015021-pol2qm74 5953 9 outcome outcome NN cord-015021-pol2qm74 5953 10 . . . cord-015021-pol2qm74 5954 1 Abdominal abdominal JJ cord-015021-pol2qm74 5954 2 bacterial bacterial JJ cord-015021-pol2qm74 5954 3 cultures culture NNS cord-015021-pol2qm74 5954 4 were be VBD cord-015021-pol2qm74 5954 5 dominated dominate VBN cord-015021-pol2qm74 5954 6 by by IN cord-015021-pol2qm74 5954 7 bacteria bacteria NNS cord-015021-pol2qm74 5954 8 of of IN cord-015021-pol2qm74 5954 9 enteric enteric JJ cord-015021-pol2qm74 5954 10 origin origin NN cord-015021-pol2qm74 5954 11 ( ( -LRB- cord-015021-pol2qm74 5954 12 83 83 CD cord-015021-pol2qm74 5954 13 % % NN cord-015021-pol2qm74 5954 14 ) ) -RRB- cord-015021-pol2qm74 5954 15 and and CC cord-015021-pol2qm74 5954 16 in in IN cord-015021-pol2qm74 5954 17 60 60 CD cord-015021-pol2qm74 5954 18 % % NN cord-015021-pol2qm74 5954 19 cultures culture NNS cord-015021-pol2qm74 5954 20 grew grow VBD cord-015021-pol2qm74 5954 21 multiple multiple JJ cord-015021-pol2qm74 5954 22 bacteria bacteria NNS cord-015021-pol2qm74 5954 23 . . . cord-015021-pol2qm74 5955 1 134 134 CD cord-015021-pol2qm74 5955 2 patients patient NNS cord-015021-pol2qm74 5955 3 bad bad JJ cord-015021-pol2qm74 5955 4 organ organ NN cord-015021-pol2qm74 5955 5 failure failure NN cord-015021-pol2qm74 5955 6 and and CC cord-015021-pol2qm74 5955 7 64 64 CD cord-015021-pol2qm74 5955 8 multiple multiple JJ cord-015021-pol2qm74 5955 9 organ organ NN cord-015021-pol2qm74 5955 10 failure failure NN cord-015021-pol2qm74 5955 11 . . . cord-015021-pol2qm74 5956 1 29/166 29/166 CD cord-015021-pol2qm74 5956 2 patients patient NNS cord-015021-pol2qm74 5956 3 ( ( -LRB- cord-015021-pol2qm74 5956 4 17 17 CD cord-015021-pol2qm74 5956 5 % % NN cord-015021-pol2qm74 5956 6 ) ) -RRB- cord-015021-pol2qm74 5956 7 had have VBD cord-015021-pol2qm74 5956 8 abdominal abdominal JJ cord-015021-pol2qm74 5956 9 sepsis sepsis NN cord-015021-pol2qm74 5956 10 due due IN cord-015021-pol2qm74 5956 11 to to IN cord-015021-pol2qm74 5956 12 diffuse diffuse VB cord-015021-pol2qm74 5956 13 peritonitis peritonitis NN cord-015021-pol2qm74 5956 14 despite despite IN cord-015021-pol2qm74 5956 15 a a DT cord-015021-pol2qm74 5956 16 morphologically morphologically RB cord-015021-pol2qm74 5956 17 intact intact JJ cord-015021-pol2qm74 5956 18 gastrointestinal gastrointestinal JJ cord-015021-pol2qm74 5956 19 tract tract NN cord-015021-pol2qm74 5956 20 and and CC cord-015021-pol2qm74 5956 21 the the DT cord-015021-pol2qm74 5956 22 absence absence NN cord-015021-pol2qm74 5956 23 of of IN cord-015021-pol2qm74 5956 24 localized localized JJ cord-015021-pol2qm74 5956 25 abscess abscess NN cord-015021-pol2qm74 5956 26 formation formation NN cord-015021-pol2qm74 5956 27 . . . cord-015021-pol2qm74 5957 1 Mortality mortality NN cord-015021-pol2qm74 5957 2 in in IN cord-015021-pol2qm74 5957 3 this this DT cord-015021-pol2qm74 5957 4 group group NN cord-015021-pol2qm74 5957 5 was be VBD cord-015021-pol2qm74 5957 6 significantly significantly RB cord-015021-pol2qm74 5957 7 higher high JJR cord-015021-pol2qm74 5957 8 as as IN cord-015021-pol2qm74 5957 9 was be VBD cord-015021-pol2qm74 5957 10 the the DT cord-015021-pol2qm74 5957 11 percentage percentage NN cord-015021-pol2qm74 5957 12 of of IN cord-015021-pol2qm74 5957 13 positive positive JJ cord-015021-pol2qm74 5957 14 blood blood NN cord-015021-pol2qm74 5957 15 cultures culture NNS cord-015021-pol2qm74 5957 16 and and CC cord-015021-pol2qm74 5957 17 the the DT cord-015021-pol2qm74 5957 18 occurrence occurrence NN cord-015021-pol2qm74 5957 19 of of IN cord-015021-pol2qm74 5957 20 multiple multiple JJ cord-015021-pol2qm74 5957 21 organ organ NN cord-015021-pol2qm74 5957 22 failure failure NN cord-015021-pol2qm74 5957 23 . . . cord-015021-pol2qm74 5958 1 Abdominal abdominal JJ cord-015021-pol2qm74 5958 2 sepsis sepsis NN cord-015021-pol2qm74 5958 3 is be VBZ cord-015021-pol2qm74 5958 4 still still RB cord-015021-pol2qm74 5958 5 associated associate VBN cord-015021-pol2qm74 5958 6 with with IN cord-015021-pol2qm74 5958 7 a a DT cord-015021-pol2qm74 5958 8 high high JJ cord-015021-pol2qm74 5958 9 mortality mortality NN cord-015021-pol2qm74 5958 10 , , , cord-015021-pol2qm74 5958 11 predominantly predominantly RB cord-015021-pol2qm74 5958 12 caused cause VBN cord-015021-pol2qm74 5958 13 by by IN cord-015021-pol2qm74 5958 14 multiple multiple JJ cord-015021-pol2qm74 5958 15 organ organ NN cord-015021-pol2qm74 5958 16 failure failure NN cord-015021-pol2qm74 5958 17 . . . cord-015021-pol2qm74 5959 1 Abdominal abdominal JJ cord-015021-pol2qm74 5959 2 culture culture NN cord-015021-pol2qm74 5959 3 findings finding NNS cord-015021-pol2qm74 5959 4 are be VBP cord-015021-pol2qm74 5959 5 dominated dominate VBN cord-015021-pol2qm74 5959 6 by by IN cord-015021-pol2qm74 5959 7 bacteria bacteria NNS cord-015021-pol2qm74 5959 8 of of IN cord-015021-pol2qm74 5959 9 enteric enteric JJ cord-015021-pol2qm74 5959 10 origin origin NN cord-015021-pol2qm74 5959 11 . . . cord-015021-pol2qm74 5960 1 In in IN cord-015021-pol2qm74 5960 2 about about IN cord-015021-pol2qm74 5960 3 1/5 1/5 CD cord-015021-pol2qm74 5960 4 of of IN cord-015021-pol2qm74 5960 5 patients patient NNS cord-015021-pol2qm74 5960 6 with with IN cord-015021-pol2qm74 5960 7 severe severe JJ cord-015021-pol2qm74 5960 8 abdominal abdominal JJ cord-015021-pol2qm74 5960 9 sepsis sepsis NN cord-015021-pol2qm74 5960 10 a a DT cord-015021-pol2qm74 5960 11 diffuse diffuse JJ cord-015021-pol2qm74 5960 12 peritonitis peritonitis NN cord-015021-pol2qm74 5960 13 with with IN cord-015021-pol2qm74 5960 14 intact intact JJ cord-015021-pol2qm74 5960 15 gastrointestinal gastrointestinal JJ cord-015021-pol2qm74 5960 16 tract tract NN cord-015021-pol2qm74 5960 17 without without IN cord-015021-pol2qm74 5960 18 localized localized JJ cord-015021-pol2qm74 5960 19 abscess abscess NN cord-015021-pol2qm74 5960 20 formation formation NN cord-015021-pol2qm74 5960 21 was be VBD cord-015021-pol2qm74 5960 22 found find VBN cord-015021-pol2qm74 5960 23 . . . cord-015021-pol2qm74 5961 1 In in IN cord-015021-pol2qm74 5961 2 this this DT cord-015021-pol2qm74 5961 3 group group NN cord-015021-pol2qm74 5961 4 the the DT cord-015021-pol2qm74 5961 5 mortality mortality NN cord-015021-pol2qm74 5961 6 was be VBD cord-015021-pol2qm74 5961 7 increased increase VBN cord-015021-pol2qm74 5961 8 as as RB cord-015021-pol2qm74 5961 9 well well RB cord-015021-pol2qm74 5961 10 as as IN cord-015021-pol2qm74 5961 11 the the DT cord-015021-pol2qm74 5961 12 risk risk NN cord-015021-pol2qm74 5961 13 of of IN cord-015021-pol2qm74 5961 14 developing develop VBG cord-015021-pol2qm74 5961 15 multiple multiple JJ cord-015021-pol2qm74 5961 16 organ organ NN cord-015021-pol2qm74 5961 17 failure failure NN cord-015021-pol2qm74 5961 18 . . . cord-015021-pol2qm74 5962 1 During during IN cord-015021-pol2qm74 5962 2 the the DT cord-015021-pol2qm74 5962 3 period period NN cord-015021-pol2qm74 5962 4 from from IN cord-015021-pol2qm74 5962 5 January January NNP cord-015021-pol2qm74 5962 6 1985 1985 CD cord-015021-pol2qm74 5962 7 to to IN cord-015021-pol2qm74 5962 8 September September NNP cord-015021-pol2qm74 5962 9 1993 1993 CD cord-015021-pol2qm74 5962 10 56 56 CD cord-015021-pol2qm74 5962 11 patients patient NNS cord-015021-pol2qm74 5962 12 , , , cord-015021-pol2qm74 5962 13 mean mean VB cord-015021-pol2qm74 5962 14 age age NN cord-015021-pol2qm74 5962 15 24 24 CD cord-015021-pol2qm74 5962 16 + + SYM cord-015021-pol2qm74 5962 17 4 4 CD cord-015021-pol2qm74 5962 18 years year NNS cord-015021-pol2qm74 5962 19 were be VBD cord-015021-pol2qm74 5962 20 referred refer VBN cord-015021-pol2qm74 5962 21 to to IN cord-015021-pol2qm74 5962 22 our -PRON- PRP$ cord-015021-pol2qm74 5962 23 department department NN cord-015021-pol2qm74 5962 24 of of IN cord-015021-pol2qm74 5962 25 Resuscitologywith Resuscitologywith NNP cord-015021-pol2qm74 5962 26 the the DT cord-015021-pol2qm74 5962 27 diagnosis diagnosis NN cord-015021-pol2qm74 5962 28 of of IN cord-015021-pol2qm74 5962 29 eclampsia eclampsia NN cord-015021-pol2qm74 5962 30 . . . cord-015021-pol2qm74 5963 1 All all PDT cord-015021-pol2qm74 5963 2 the the DT cord-015021-pol2qm74 5963 3 patients patient NNS cord-015021-pol2qm74 5963 4 were be VBD cord-015021-pol2qm74 5963 5 delivered deliver VBN cord-015021-pol2qm74 5963 6 by by IN cord-015021-pol2qm74 5963 7 cesarian cesarian NN cord-015021-pol2qm74 5963 8 section section NN cord-015021-pol2qm74 5963 9 and and CC cord-015021-pol2qm74 5963 10 were be VBD cord-015021-pol2qm74 5963 11 mechanically mechanically RB cord-015021-pol2qm74 5963 12 ventilated ventilate VBN cord-015021-pol2qm74 5963 13 for for IN cord-015021-pol2qm74 5963 14 7.3_+5.7 7.3_+5.7 CD cord-015021-pol2qm74 5963 15 days day NNS cord-015021-pol2qm74 5963 16 . . . cord-015021-pol2qm74 5964 1 Diagnosis diagnosis NN cord-015021-pol2qm74 5964 2 of of IN cord-015021-pol2qm74 5964 3 sepsis sepsis NN cord-015021-pol2qm74 5964 4 was be VBD cord-015021-pol2qm74 5964 5 confirmed confirm VBN cord-015021-pol2qm74 5964 6 in in IN cord-015021-pol2qm74 5964 7 6 6 CD cord-015021-pol2qm74 5964 8 cases case NNS cord-015021-pol2qm74 5964 9 by by IN cord-015021-pol2qm74 5964 10 clinical clinical JJ cord-015021-pol2qm74 5964 11 and and CC cord-015021-pol2qm74 5964 12 microbiological microbiological JJ cord-015021-pol2qm74 5964 13 methods method NNS cord-015021-pol2qm74 5964 14 . . . cord-015021-pol2qm74 5965 1 Patients patient NNS cord-015021-pol2qm74 5965 2 were be VBD cord-015021-pol2qm74 5965 3 divided divide VBN cord-015021-pol2qm74 5965 4 in in IN cord-015021-pol2qm74 5965 5 two two CD cord-015021-pol2qm74 5965 6 groups group NNS cord-015021-pol2qm74 5965 7 : : : cord-015021-pol2qm74 5965 8 lnon lnon NN cord-015021-pol2qm74 5965 9 septic septic JJ cord-015021-pol2qm74 5965 10 patients patient NNS cord-015021-pol2qm74 5965 11 , , , cord-015021-pol2qm74 5965 12 2-patients 2-patients CD cord-015021-pol2qm74 5965 13 with with IN cord-015021-pol2qm74 5965 14 sepsis sepsis NN cord-015021-pol2qm74 5965 15 , , , cord-015021-pol2qm74 5965 16 the the DT cord-015021-pol2qm74 5965 17 control control NN cord-015021-pol2qm74 5965 18 group group NN cord-015021-pol2qm74 5965 19 consisted consist VBD cord-015021-pol2qm74 5965 20 of of IN cord-015021-pol2qm74 5965 21 20 20 CD cord-015021-pol2qm74 5965 22 patients patient NNS cord-015021-pol2qm74 5965 23 after after IN cord-015021-pol2qm74 5965 24 cesarian cesarian NN cord-015021-pol2qm74 5965 25 section section NN cord-015021-pol2qm74 5965 26 without without IN cord-015021-pol2qm74 5965 27 symptoms symptom NNS cord-015021-pol2qm74 5965 28 of of IN cord-015021-pol2qm74 5965 29 eclampsia eclampsia NN cord-015021-pol2qm74 5965 30 or or CC cord-015021-pol2qm74 5965 31 infection infection NN cord-015021-pol2qm74 5965 32 . . . cord-015021-pol2qm74 5966 1 We -PRON- PRP cord-015021-pol2qm74 5966 2 determined determine VBD cord-015021-pol2qm74 5966 3 plasma plasma NN cord-015021-pol2qm74 5966 4 concentrations concentration NNS cord-015021-pol2qm74 5966 5 of of IN cord-015021-pol2qm74 5966 6 immunoglobulins immunoglobulin NNS cord-015021-pol2qm74 5966 7 A A NNP cord-015021-pol2qm74 5966 8 , , , cord-015021-pol2qm74 5966 9 G G NNP cord-015021-pol2qm74 5966 10 , , , cord-015021-pol2qm74 5966 11 M(A M(A NNP cord-015021-pol2qm74 5966 12 , , , cord-015021-pol2qm74 5966 13 G G NNP cord-015021-pol2qm74 5966 14 , , , cord-015021-pol2qm74 5966 15 M M NNP cord-015021-pol2qm74 5966 16 ) ) -RRB- cord-015021-pol2qm74 5966 17 , , , cord-015021-pol2qm74 5966 18 complement complement NN cord-015021-pol2qm74 5966 19 factors factor NNS cord-015021-pol2qm74 5966 20 ( ( -LRB- cord-015021-pol2qm74 5966 21 C3,C4 C3,C4 NNP cord-015021-pol2qm74 5966 22 ) ) -RRB- cord-015021-pol2qm74 5966 23 , , , cord-015021-pol2qm74 5966 24 alphal alphal NN cord-015021-pol2qm74 5966 25 - - HYPH cord-015021-pol2qm74 5966 26 antitrypsin antitrypsin NN cord-015021-pol2qm74 5966 27 ( ( -LRB- cord-015021-pol2qm74 5966 28 AAT AAT NNP cord-015021-pol2qm74 5966 29 ) ) -RRB- cord-015021-pol2qm74 5966 30 , , , cord-015021-pol2qm74 5966 31 trausferrin trausferrin NNP cord-015021-pol2qm74 5966 32 ( ( -LRB- cord-015021-pol2qm74 5966 33 TRF TRF NNP cord-015021-pol2qm74 5966 34 ) ) -RRB- cord-015021-pol2qm74 5966 35 and and CC cord-015021-pol2qm74 5966 36 albumin albumin NN cord-015021-pol2qm74 5966 37 ( ( -LRB- cord-015021-pol2qm74 5966 38 ALB ALB NNP cord-015021-pol2qm74 5966 39 ) ) -RRB- cord-015021-pol2qm74 5966 40 using use VBG cord-015021-pol2qm74 5966 41 BECKMAN BECKMAN NNP cord-015021-pol2qm74 5966 42 ( ( -LRB- cord-015021-pol2qm74 5966 43 USA USA NNP cord-015021-pol2qm74 5966 44 ) ) -RRB- cord-015021-pol2qm74 5966 45 analyzer analyzer NN cord-015021-pol2qm74 5966 46 , , , cord-015021-pol2qm74 5966 47 protein protein NN cord-015021-pol2qm74 5966 48 concentration concentration NN cord-015021-pol2qm74 5966 49 , , , cord-015021-pol2qm74 5966 50 using use VBG cord-015021-pol2qm74 5966 51 KONE KONE NNP cord-015021-pol2qm74 5966 52 ( ( -LRB- cord-015021-pol2qm74 5966 53 Finland Finland NNP cord-015021-pol2qm74 5966 54 ) ) -RRB- cord-015021-pol2qm74 5966 55 analyzer analyzer NN cord-015021-pol2qm74 5966 56 . . . cord-015021-pol2qm74 5967 1 A(mg A(mg NNP cord-015021-pol2qm74 5968 1 /dL /dL NFP cord-015021-pol2qm74 5968 2 ) ) -RRB- cord-015021-pol2qm74 5969 1 G(mg G(mg NNP cord-015021-pol2qm74 5969 2 / / SYM cord-015021-pol2qm74 5969 3 dL dl NN cord-015021-pol2qm74 5969 4 ) ) -RRB- cord-015021-pol2qm74 5970 1 M(mg M(mg NNP cord-015021-pol2qm74 5970 2 / / SYM cord-015021-pol2qm74 5970 3 dL dl NN cord-015021-pol2qm74 5970 4 ) ) -RRB- cord-015021-pol2qm74 5971 1 C3(mg c3(mg NN cord-015021-pol2qm74 5971 2 / / SYM cord-015021-pol2qm74 5971 3 dL dl NN cord-015021-pol2qm74 5971 4 ) ) -RRB- cord-015021-pol2qm74 5972 1 C4(mg C4(mg NNP cord-015021-pol2qm74 5972 2 / / SYM cord-015021-pol2qm74 5972 3 dL dl NN cord-015021-pol2qm74 5972 4 ) ) -RRB- cord-015021-pol2qm74 5973 1 K K NNP cord-015021-pol2qm74 5973 2 203 203 CD cord-015021-pol2qm74 5973 3 + + CC cord-015021-pol2qm74 5973 4 -31 -31 CD cord-015021-pol2qm74 5973 5 971 971 CD cord-015021-pol2qm74 5973 6 + + SYM cord-015021-pol2qm74 5973 7 47 47 CD cord-015021-pol2qm74 5973 8 205_+21 205_+21 CD cord-015021-pol2qm74 5974 1 134 134 CD cord-015021-pol2qm74 5974 2 + + SYM cord-015021-pol2qm74 5974 3 12 12 CD cord-015021-pol2qm74 5974 4 30 30 CD cord-015021-pol2qm74 5974 5 + + CD cord-015021-pol2qm74 5975 1 -3 -3 NNP cord-015021-pol2qm74 5975 2 1 1 CD cord-015021-pol2qm74 5975 3 154-+29 154-+29 CD cord-015021-pol2qm74 5975 4 " " `` cord-015021-pol2qm74 5975 5 568-+48 568-+48 NNP cord-015021-pol2qm74 5975 6 * * NFP cord-015021-pol2qm74 5975 7 142_+24 142_+24 CD cord-015021-pol2qm74 5975 8 " " `` cord-015021-pol2qm74 5975 9 81-+14 81-+14 CD cord-015021-pol2qm74 5975 10 ' ' CD cord-015021-pol2qm74 5975 11 17_+4 17_+4 CD cord-015021-pol2qm74 5975 12 " " '' cord-015021-pol2qm74 5975 13 2 2 CD cord-015021-pol2qm74 5975 14 102+_21 102+_21 CD cord-015021-pol2qm74 5975 15 ' ' POS cord-015021-pol2qm74 5975 16 * * NFP cord-015021-pol2qm74 5975 17 420-+30 420-+30 CD cord-015021-pol2qm74 5975 18 * * NFP cord-015021-pol2qm74 5975 19 * * NFP cord-015021-pol2qm74 5975 20 96-+21 96-+21 CD cord-015021-pol2qm74 5976 1 " " `` cord-015021-pol2qm74 5976 2 * * NFP cord-015021-pol2qm74 5976 3 67-+10 67-+10 CD cord-015021-pol2qm74 5976 4 " " '' cord-015021-pol2qm74 5977 1 * * NFP cord-015021-pol2qm74 5977 2 11_+3 11_+3 CD cord-015021-pol2qm74 5977 3 " " `` cord-015021-pol2qm74 5977 4 In in IN cord-015021-pol2qm74 5977 5 a a DT cord-015021-pol2qm74 5977 6 prospective prospective JJ cord-015021-pol2qm74 5977 7 study study NN cord-015021-pol2qm74 5977 8 we -PRON- PRP cord-015021-pol2qm74 5977 9 investigated investigate VBD cord-015021-pol2qm74 5977 10 serum serum NN cord-015021-pol2qm74 5977 11 of of IN cord-015021-pol2qm74 5977 12 12 12 CD cord-015021-pol2qm74 5977 13 severly severly RB cord-015021-pol2qm74 5977 14 traumatized traumatize VBN cord-015021-pol2qm74 5977 15 patients patient NNS cord-015021-pol2qm74 5977 16 withdrawn withdraw VBN cord-015021-pol2qm74 5977 17 directly directly RB cord-015021-pol2qm74 5977 18 after after IN cord-015021-pol2qm74 5977 19 admission admission NN cord-015021-pol2qm74 5977 20 at at IN cord-015021-pol2qm74 5977 21 our -PRON- PRP$ cord-015021-pol2qm74 5977 22 hospital hospital NN cord-015021-pol2qm74 5977 23 ( ( -LRB- cord-015021-pol2qm74 5977 24 TR TR NNP cord-015021-pol2qm74 5977 25 I I NNP cord-015021-pol2qm74 5977 26 ) ) -RRB- cord-015021-pol2qm74 5977 27 . . . cord-015021-pol2qm74 5978 1 Follow follow VB cord-015021-pol2qm74 5978 2 up up RP cord-015021-pol2qm74 5978 3 controls control NNS cord-015021-pol2qm74 5978 4 were be VBD cord-015021-pol2qm74 5978 5 taken take VBN cord-015021-pol2qm74 5978 6 daily daily RB cord-015021-pol2qm74 5978 7 until until IN cord-015021-pol2qm74 5978 8 day day NN cord-015021-pol2qm74 5978 9 ten ten CD cord-015021-pol2qm74 5978 10 after after IN cord-015021-pol2qm74 5978 11 trauma trauma NN cord-015021-pol2qm74 5978 12 ( ( -LRB- cord-015021-pol2qm74 5978 13 TR TR NNP cord-015021-pol2qm74 5978 14 II II NNP cord-015021-pol2qm74 5978 15 ) ) -RRB- cord-015021-pol2qm74 5978 16 . . . cord-015021-pol2qm74 5979 1 Two two CD cord-015021-pol2qm74 5979 2 control control NN cord-015021-pol2qm74 5979 3 groups group NNS cord-015021-pol2qm74 5979 4 were be VBD cord-015021-pol2qm74 5979 5 performed perform VBN cord-015021-pol2qm74 5979 6 : : : cord-015021-pol2qm74 5979 7 Serum serum NN cord-015021-pol2qm74 5979 8 of of IN cord-015021-pol2qm74 5979 9 healthy healthy JJ cord-015021-pol2qm74 5979 10 volunteers volunteer NNS cord-015021-pol2qm74 5979 11 ( ( -LRB- cord-015021-pol2qm74 5979 12 CO CO NNP cord-015021-pol2qm74 5979 13 , , , cord-015021-pol2qm74 5979 14 n n NN cord-015021-pol2qm74 5979 15 = = SYM cord-015021-pol2qm74 5979 16 24 24 CD cord-015021-pol2qm74 5979 17 ) ) -RRB- cord-015021-pol2qm74 5979 18 was be VBD cord-015021-pol2qm74 5979 19 investigated investigate VBN cord-015021-pol2qm74 5979 20 as as IN cord-015021-pol2qm74 5979 21 . . . cord-015021-pol2qm74 5980 1 well well UH cord-015021-pol2qm74 5980 2 as as IN cord-015021-pol2qm74 5980 3 serum serum NN cord-015021-pol2qm74 5980 4 of of IN cord-015021-pol2qm74 5980 5 patients patient NNS cord-015021-pol2qm74 5980 6 undergoing undergo VBG cord-015021-pol2qm74 5980 7 elective elective JJ cord-015021-pol2qm74 5980 8 herniotomy herniotomy NN cord-015021-pol2qm74 5980 9 ( ( -LRB- cord-015021-pol2qm74 5980 10 n=12 n=12 NNP cord-015021-pol2qm74 5980 11 ) ) -RRB- cord-015021-pol2qm74 5980 12 24 24 CD cord-015021-pol2qm74 5980 13 hours hour NNS cord-015021-pol2qm74 5980 14 before before IN cord-015021-pol2qm74 5980 15 ( ( -LRB- cord-015021-pol2qm74 5980 16 OP OP NNP cord-015021-pol2qm74 5980 17 I I NNP cord-015021-pol2qm74 5980 18 ) ) -RRB- cord-015021-pol2qm74 5980 19 and and CC cord-015021-pol2qm74 5980 20 24 24 CD cord-015021-pol2qm74 5980 21 hours hour NNS cord-015021-pol2qm74 5980 22 after after IN cord-015021-pol2qm74 5980 23 operation operation NN cord-015021-pol2qm74 5980 24 ( ( -LRB- cord-015021-pol2qm74 5980 25 OP OP NNP cord-015021-pol2qm74 5980 26 II II NNP cord-015021-pol2qm74 5980 27 ) ) -RRB- cord-015021-pol2qm74 5980 28 . . . cord-015021-pol2qm74 5981 1 Serum serum NN cord-015021-pol2qm74 5981 2 bactericidal bactericidal JJ cord-015021-pol2qm74 5981 3 index index NN cord-015021-pol2qm74 5981 4 ( ( -LRB- cord-015021-pol2qm74 5981 5 SBI SBI NNP cord-015021-pol2qm74 5981 6 ) ) -RRB- cord-015021-pol2qm74 5981 7 was be VBD cord-015021-pol2qm74 5981 8 determined determine VBN cord-015021-pol2qm74 5981 9 using use VBG cord-015021-pol2qm74 5981 10 a a DT cord-015021-pol2qm74 5981 11 hemolytic hemolytic JJ cord-015021-pol2qm74 5981 12 E.coli e.coli NN cord-015021-pol2qm74 5981 13 strain strain NN cord-015021-pol2qm74 5981 14 08 08 CD cord-015021-pol2qm74 5981 15 : : : cord-015021-pol2qm74 5981 16 K87 k87 JJ cord-015021-pol2qm74 5981 17 : : : cord-015021-pol2qm74 5981 18 H19 H19 NNP cord-015021-pol2qm74 5981 19 . . . cord-015021-pol2qm74 5982 1 200/11 200/11 NNS cord-015021-pol2qm74 5982 2 suspension suspension NN cord-015021-pol2qm74 5982 3 with with IN cord-015021-pol2qm74 5982 4 a a DT cord-015021-pol2qm74 5982 5 final final JJ cord-015021-pol2qm74 5982 6 concentration concentration NN cord-015021-pol2qm74 5982 7 of of IN cord-015021-pol2qm74 5982 8 250 250 CD cord-015021-pol2qm74 5982 9 -400 -400 NN cord-015021-pol2qm74 5982 10 CFU CFU NNP cord-015021-pol2qm74 5982 11 were be VBD cord-015021-pol2qm74 5982 12 incubated incubate VBN cord-015021-pol2qm74 5982 13 with with IN cord-015021-pol2qm74 5982 14 l l NNP cord-015021-pol2qm74 5982 15 OOpl OOpl NNP cord-015021-pol2qm74 5982 16 serum serum NN cord-015021-pol2qm74 5982 17 . . . cord-015021-pol2qm74 5983 1 After after IN cord-015021-pol2qm74 5983 2 overnight overnight JJ cord-015021-pol2qm74 5983 3 incubation incubation NN cord-015021-pol2qm74 5983 4 SBI SBI NNP cord-015021-pol2qm74 5983 5 was be VBD cord-015021-pol2qm74 5983 6 calculated calculate VBN cord-015021-pol2qm74 5983 7 according accord VBG cord-015021-pol2qm74 5983 8 a a DT cord-015021-pol2qm74 5983 9 special special JJ cord-015021-pol2qm74 5983 10 formula formula NN cord-015021-pol2qm74 5983 11 . . . cord-015021-pol2qm74 5984 1 Results result NNS cord-015021-pol2qm74 5984 2 : : : cord-015021-pol2qm74 5984 3 CO co NN cord-015021-pol2qm74 5985 1 74.8 74.8 CD cord-015021-pol2qm74 5985 2 _ _ NN cord-015021-pol2qm74 5985 3 + + SYM cord-015021-pol2qm74 5985 4 6.3 6.3 CD cord-015021-pol2qm74 5985 5 OPI OPI NNP cord-015021-pol2qm74 5985 6 77.8 77.8 NNP cord-015021-pol2qm74 5985 7 _ _ NNP cord-015021-pol2qm74 5985 8 + + CC cord-015021-pol2qm74 5985 9 6.4 6.4 CD cord-015021-pol2qm74 5985 10 OPII opii JJ cord-015021-pol2qm74 5985 11 68.2 68.2 CD cord-015021-pol2qm74 5985 12 _ _ NN cord-015021-pol2qm74 5986 1 + + CC cord-015021-pol2qm74 5987 1 7.7 7.7 CD cord-015021-pol2qm74 5987 2 * * NFP cord-015021-pol2qm74 5987 3 TRI tri NN cord-015021-pol2qm74 5988 1 38.4 38.4 CD cord-015021-pol2qm74 5988 2 _ _ NN cord-015021-pol2qm74 5988 3 + + SYM cord-015021-pol2qm74 5988 4 9.1 9.1 CD cord-015021-pol2qm74 5988 5 " " '' cord-015021-pol2qm74 5989 1 * * NFP cord-015021-pol2qm74 5989 2 TRII TRII NNP cord-015021-pol2qm74 5989 3 57.6 57.6 CD cord-015021-pol2qm74 5989 4 + + SYM cord-015021-pol2qm74 5989 5 8.9 8.9 CD cord-015021-pol2qm74 5990 1 * * NFP cord-015021-pol2qm74 5990 2 * * NFP cord-015021-pol2qm74 5990 3 ( ( -LRB- cord-015021-pol2qm74 5990 4 * * NFP cord-015021-pol2qm74 5990 5 :p :p NFP cord-015021-pol2qm74 5990 6 < < XX cord-015021-pol2qm74 5990 7 0.05 0.05 CD cord-015021-pol2qm74 5990 8 ; ; : cord-015021-pol2qm74 5991 1 * * NFP cord-015021-pol2qm74 5991 2 * * NFP cord-015021-pol2qm74 5991 3 :p :p . cord-015021-pol2qm74 5991 4 < < XX cord-015021-pol2qm74 5992 1 O.01 o.01 CD cord-015021-pol2qm74 5992 2 ) ) -RRB- cord-015021-pol2qm74 5993 1 SBI SBI NNP cord-015021-pol2qm74 5993 2 represents represent VBZ cord-015021-pol2qm74 5993 3 a a DT cord-015021-pol2qm74 5993 4 simple simple JJ cord-015021-pol2qm74 5993 5 and and CC cord-015021-pol2qm74 5993 6 reproducible reproducible JJ cord-015021-pol2qm74 5993 7 method method NN cord-015021-pol2qm74 5993 8 to to TO cord-015021-pol2qm74 5993 9 detect detect VB cord-015021-pol2qm74 5993 10 immunobiological immunobiological JJ cord-015021-pol2qm74 5993 11 alterations alteration NNS cord-015021-pol2qm74 5993 12 after after IN cord-015021-pol2qm74 5993 13 trauma trauma NN cord-015021-pol2qm74 5993 14 and and CC cord-015021-pol2qm74 5993 15 elective elective JJ cord-015021-pol2qm74 5993 16 surgery surgery NN cord-015021-pol2qm74 5993 17 . . . cord-015021-pol2qm74 5994 1 Patients patient NNS cord-015021-pol2qm74 5994 2 undergoing undergo VBG cord-015021-pol2qm74 5994 3 elective elective JJ cord-015021-pol2qm74 5994 4 surgery surgery NN cord-015021-pol2qm74 5994 5 showed show VBD cord-015021-pol2qm74 5994 6 slight slight JJ cord-015021-pol2qm74 5994 7 but but CC cord-015021-pol2qm74 5994 8 significant significant JJ cord-015021-pol2qm74 5994 9 diminuation diminuation NN cord-015021-pol2qm74 5994 10 of of IN cord-015021-pol2qm74 5994 11 SBI SBI NNP cord-015021-pol2qm74 5994 12 24h 24h NNS cord-015021-pol2qm74 5994 13 after after IN cord-015021-pol2qm74 5994 14 operation operation NN cord-015021-pol2qm74 5994 15 . . . cord-015021-pol2qm74 5995 1 Deterioration deterioration NN cord-015021-pol2qm74 5995 2 of of IN cord-015021-pol2qm74 5995 3 SBI SBI NNP cord-015021-pol2qm74 5995 4 was be VBD cord-015021-pol2qm74 5995 5 observed observe VBN cord-015021-pol2qm74 5995 6 in in IN cord-015021-pol2qm74 5995 7 serum serum NN cord-015021-pol2qm74 5995 8 of of IN cord-015021-pol2qm74 5995 9 traumatized traumatize VBN cord-015021-pol2qm74 5995 10 patients patient NNS cord-015021-pol2qm74 5995 11 directly directly RB cord-015021-pol2qm74 5995 12 withdrawn withdraw VBN cord-015021-pol2qm74 5995 13 after after IN cord-015021-pol2qm74 5995 14 admission admission NN cord-015021-pol2qm74 5995 15 at at IN cord-015021-pol2qm74 5995 16 our -PRON- PRP$ cord-015021-pol2qm74 5995 17 hospital hospital NN cord-015021-pol2qm74 5995 18 . . . cord-015021-pol2qm74 5996 1 Ten ten CD cord-015021-pol2qm74 5996 2 days day NNS cord-015021-pol2qm74 5996 3 after after IN cord-015021-pol2qm74 5996 4 trauma trauma NN cord-015021-pol2qm74 5996 5 significant significant JJ cord-015021-pol2qm74 5996 6 improvement improvement NN cord-015021-pol2qm74 5996 7 of of IN cord-015021-pol2qm74 5996 8 SBI SBI NNP cord-015021-pol2qm74 5996 9 was be VBD cord-015021-pol2qm74 5996 10 found find VBN cord-015021-pol2qm74 5996 11 . . . cord-015021-pol2qm74 5997 1 Further further JJ cord-015021-pol2qm74 5997 2 investigations investigation NNS cord-015021-pol2qm74 5997 3 have have VBP cord-015021-pol2qm74 5997 4 to to TO cord-015021-pol2qm74 5997 5 be be VB cord-015021-pol2qm74 5997 6 done do VBN cord-015021-pol2qm74 5997 7 to to IN cord-015021-pol2qm74 5997 8 proof proof NN cord-015021-pol2qm74 5997 9 sensitivity sensitivity NN cord-015021-pol2qm74 5997 10 and and CC cord-015021-pol2qm74 5997 11 prospectivity prospectivity NN cord-015021-pol2qm74 5997 12 of of IN cord-015021-pol2qm74 5997 13 this this DT cord-015021-pol2qm74 5997 14 simple simple JJ cord-015021-pol2qm74 5997 15 but but CC cord-015021-pol2qm74 5997 16 reliable reliable JJ cord-015021-pol2qm74 5997 17 test test NN cord-015021-pol2qm74 5997 18 . . . cord-015021-pol2qm74 5998 1 A a DT cord-015021-pol2qm74 5998 2 sepsis sepsis NN cord-015021-pol2qm74 5998 3 like like IN cord-015021-pol2qm74 5998 4 syndrome syndrome NN cord-015021-pol2qm74 5998 5 ( ( -LRB- cord-015021-pol2qm74 5998 6 SLS SLS NNP cord-015021-pol2qm74 5998 7 ) ) -RRB- cord-015021-pol2qm74 5998 8 occurs occur VBZ cord-015021-pol2qm74 5998 9 in in IN cord-015021-pol2qm74 5998 10 i0 i0 NN cord-015021-pol2qm74 5998 11 % % NN cord-015021-pol2qm74 5998 12 of of IN cord-015021-pol2qm74 5998 13 our -PRON- PRP$ cord-015021-pol2qm74 5998 14 patients patient NNS cord-015021-pol2qm74 5998 15 following follow VBG cord-015021-pol2qm74 5998 16 cardiac cardiac JJ cord-015021-pol2qm74 5998 17 surgery surgery NN cord-015021-pol2qm74 5998 18 . . . cord-015021-pol2qm74 5999 1 SLS SLS NNP cord-015021-pol2qm74 5999 2 is be VBZ cord-015021-pol2qm74 5999 3 characterized characterize VBN cord-015021-pol2qm74 5999 4 by by IN cord-015021-pol2qm74 5999 5 a a DT cord-015021-pol2qm74 5999 6 severe severe JJ cord-015021-pol2qm74 5999 7 decrease decrease NN cord-015021-pol2qm74 5999 8 in in IN cord-015021-pol2qm74 5999 9 systemic systemic JJ cord-015021-pol2qm74 5999 10 vascular vascular JJ cord-015021-pol2qm74 5999 11 resistance resistance NN cord-015021-pol2qm74 5999 12 requiring require VBG cord-015021-pol2qm74 5999 13 the the DT cord-015021-pol2qm74 5999 14 use use NN cord-015021-pol2qm74 5999 15 of of IN cord-015021-pol2qm74 5999 16 vasopressors vasopressor NNS cord-015021-pol2qm74 5999 17 to to TO cord-015021-pol2qm74 5999 18 maintain maintain VB cord-015021-pol2qm74 5999 19 adequate adequate JJ cord-015021-pol2qm74 5999 20 hemodynamics hemodynamic NNS cord-015021-pol2qm74 5999 21 in in IN cord-015021-pol2qm74 5999 22 the the DT cord-015021-pol2qm74 5999 23 presence presence NN cord-015021-pol2qm74 5999 24 of of IN cord-015021-pol2qm74 5999 25 negative negative JJ cord-015021-pol2qm74 5999 26 blood blood NN cord-015021-pol2qm74 5999 27 cultures culture NNS cord-015021-pol2qm74 5999 28 . . . cord-015021-pol2qm74 6000 1 In in IN cord-015021-pol2qm74 6000 2 order order NN cord-015021-pol2qm74 6000 3 to to TO cord-015021-pol2qm74 6000 4 determine determine VB cord-015021-pol2qm74 6000 5 whether whether IN cord-015021-pol2qm74 6000 6 preoperative preoperative JJ cord-015021-pol2qm74 6000 7 factors factor NNS cord-015021-pol2qm74 6000 8 predict predict VBP cord-015021-pol2qm74 6000 9 the the DT cord-015021-pol2qm74 6000 10 occurrence occurrence NN cord-015021-pol2qm74 6000 11 SLS SLS NNP cord-015021-pol2qm74 6000 12 we -PRON- PRP cord-015021-pol2qm74 6000 13 retrospectively retrospectively RB cord-015021-pol2qm74 6000 14 studied study VBD cord-015021-pol2qm74 6000 15 62 62 CD cord-015021-pol2qm74 6000 16 patients patient NNS cord-015021-pol2qm74 6000 17 with with IN cord-015021-pol2qm74 6000 18 SLS SLS NNP cord-015021-pol2qm74 6000 19 ( ( -LRB- cord-015021-pol2qm74 6000 20 group group NN cord-015021-pol2qm74 6000 21 i i PRP cord-015021-pol2qm74 6000 22 : : : cord-015021-pol2qm74 6000 23 age age NN cord-015021-pol2qm74 6000 24 61.1 61.1 CD cord-015021-pol2qm74 6000 25 ~ ~ NFP cord-015021-pol2qm74 6000 26 10.8 10.8 CD cord-015021-pol2qm74 6000 27 years year NNS cord-015021-pol2qm74 6000 28 ) ) -RRB- cord-015021-pol2qm74 6000 29 ; ; : cord-015021-pol2qm74 6000 30 they -PRON- PRP cord-015021-pol2qm74 6000 31 were be VBD cord-015021-pol2qm74 6000 32 compared compare VBN cord-015021-pol2qm74 6000 33 to to IN cord-015021-pol2qm74 6000 34 52 52 CD cord-015021-pol2qm74 6000 35 control control NN cord-015021-pol2qm74 6000 36 patients patient NNS cord-015021-pol2qm74 6000 37 ( ( -LRB- cord-015021-pol2qm74 6000 38 group group NN cord-015021-pol2qm74 6000 39 2 2 CD cord-015021-pol2qm74 6000 40 : : : cord-015021-pol2qm74 6000 41 age age NN cord-015021-pol2qm74 6000 42 58 58 CD cord-015021-pol2qm74 6000 43 ± ± CD cord-015021-pol2qm74 6000 44 14.3 14.3 CD cord-015021-pol2qm74 6000 45 years year NNS cord-015021-pol2qm74 6000 46 ) ) -RRB- cord-015021-pol2qm74 6000 47 . . . cord-015021-pol2qm74 6001 1 Treatment treatment NN cord-015021-pol2qm74 6001 2 of of IN cord-015021-pol2qm74 6001 3 SLS SLS NNP cord-015021-pol2qm74 6001 4 consisted consist VBD cord-015021-pol2qm74 6001 5 of of IN cord-015021-pol2qm74 6001 6 aggressive aggressive JJ cord-015021-pol2qm74 6001 7 fluid fluid JJ cord-015021-pol2qm74 6001 8 replacement replacement NN cord-015021-pol2qm74 6001 9 and and CC cord-015021-pol2qm74 6001 10 norepinephrine norepinephrine NN cord-015021-pol2qm74 6001 11 infusion infusion NN cord-015021-pol2qm74 6001 12 . . . cord-015021-pol2qm74 6002 1 Rydrocortisone Rydrocortisone NNP cord-015021-pol2qm74 6002 2 ( ( -LRB- cord-015021-pol2qm74 6002 3 200 200 CD cord-015021-pol2qm74 6002 4 mg/24 mg/24 CD cord-015021-pol2qm74 6002 5 hrs hrs NN cord-015021-pol2qm74 6002 6 ) ) -RRB- cord-015021-pol2qm74 6002 7 was be VBD cord-015021-pol2qm74 6002 8 given give VBN cord-015021-pol2qm74 6002 9 on on IN cord-015021-pol2qm74 6002 10 the the DT cord-015021-pol2qm74 6002 11 first first JJ cord-015021-pol2qm74 6002 12 day day NN cord-015021-pol2qm74 6002 13 . . . cord-015021-pol2qm74 6003 1 Antibiotics antibiotic NNS cord-015021-pol2qm74 6003 2 were be VBD cord-015021-pol2qm74 6003 3 switched switch VBN cord-015021-pol2qm74 6003 4 prophylactic prophylactic JJ cord-015021-pol2qm74 6003 5 to to TO cord-015021-pol2qm74 6003 6 cover cover VB cord-015021-pol2qm74 6003 7 gramnegative gramnegative JJ cord-015021-pol2qm74 6003 8 bacteria bacteria NNS cord-015021-pol2qm74 6003 9 in in IN cord-015021-pol2qm74 6003 10 48 48 CD cord-015021-pol2qm74 6003 11 pts pt NNS cord-015021-pol2qm74 6003 12 . . . cord-015021-pol2qm74 6004 1 Preoperatively Preoperatively NNP cord-015021-pol2qm74 6004 2 pts pts NNP cord-015021-pol2qm74 6004 3 in in IN cord-015021-pol2qm74 6004 4 group group NN cord-015021-pol2qm74 6004 5 1 1 CD cord-015021-pol2qm74 6004 6 revealed reveal VBD cord-015021-pol2qm74 6004 7 a a DT cord-015021-pol2qm74 6004 8 significantly significantly RB cord-015021-pol2qm74 6004 9 lower low JJR cord-015021-pol2qm74 6004 10 cardiac cardiac JJ cord-015021-pol2qm74 6004 11 index index NN cord-015021-pol2qm74 6004 12 ( ( -LRB- cord-015021-pol2qm74 6004 13 2.5 2.5 CD cord-015021-pol2qm74 6004 14 ± ± NNP cord-015021-pol2qm74 6004 15 1 1 CD cord-015021-pol2qm74 6004 16 i i NNP cord-015021-pol2qm74 6004 17 / / SYM cord-015021-pol2qm74 6004 18 min min NNP cord-015021-pol2qm74 6004 19 / / SYM cord-015021-pol2qm74 6004 20 m m NNP cord-015021-pol2qm74 6004 21 2 2 CD cord-015021-pol2qm74 6004 22 ) ) -RRB- cord-015021-pol2qm74 6004 23 compared compare VBN cord-015021-pol2qm74 6004 24 to to IN cord-015021-pol2qm74 6004 25 group group NN cord-015021-pol2qm74 6004 26 2 2 CD cord-015021-pol2qm74 6004 27 ( ( -LRB- cord-015021-pol2qm74 6004 28 3.1 3.1 CD cord-015021-pol2qm74 6004 29 ± ± CD cord-015021-pol2qm74 6004 30 1.2 1.2 CD cord-015021-pol2qm74 6004 31 i i NNP cord-015021-pol2qm74 6004 32 / / SYM cord-015021-pol2qm74 6004 33 min min NNP cord-015021-pol2qm74 6004 34 / / SYM cord-015021-pol2qm74 6004 35 m2 m2 NNP cord-015021-pol2qm74 6004 36 ; ; : cord-015021-pol2qm74 6004 37 p p NN cord-015021-pol2qm74 6004 38 < < XX cord-015021-pol2qm74 6004 39 .02 .02 NFP cord-015021-pol2qm74 6004 40 ) ) -RRB- cord-015021-pol2qm74 6005 1 higher high JJR cord-015021-pol2qm74 6005 2 left left JJ cord-015021-pol2qm74 6005 3 atrial atrial JJ cord-015021-pol2qm74 6005 4 pressure pressure NN cord-015021-pol2qm74 6005 5 ( ( -LRB- cord-015021-pol2qm74 6005 6 group group NN cord-015021-pol2qm74 6005 7 i i PRP cord-015021-pol2qm74 6005 8 : : : cord-015021-pol2qm74 6005 9 17.8 17.8 CD cord-015021-pol2qm74 6005 10 ~ ~ NFP cord-015021-pol2qm74 6005 11 8.1 8.1 CD cord-015021-pol2qm74 6005 12 mmHg mmHg NNS cord-015021-pol2qm74 6005 13 ; ; : cord-015021-pol2qm74 6005 14 group group NN cord-015021-pol2qm74 6005 15 2 2 CD cord-015021-pol2qm74 6005 16 : : : cord-015021-pol2qm74 6005 17 13.1 13.1 CD cord-015021-pol2qm74 6005 18 ~ ~ NFP cord-015021-pol2qm74 6005 19 6.1 6.1 CD cord-015021-pol2qm74 6005 20 mmHg mmHg NNS cord-015021-pol2qm74 6005 21 ; ; : cord-015021-pol2qm74 6005 22 p p NN cord-015021-pol2qm74 6005 23 < < XX cord-015021-pol2qm74 6005 24 .005 .005 NFP cord-015021-pol2qm74 6005 25 ) ) -RRB- cord-015021-pol2qm74 6005 26 and and CC cord-015021-pol2qm74 6005 27 lower low JJR cord-015021-pol2qm74 6005 28 ejection ejection NN cord-015021-pol2qm74 6005 29 fraction fraction NN cord-015021-pol2qm74 6006 1 ( ( -LRB- cord-015021-pol2qm74 6006 2 group group NN cord-015021-pol2qm74 6006 3 i i PRP cord-015021-pol2qm74 6006 4 : : : cord-015021-pol2qm74 6006 5 57.9 57.9 CD cord-015021-pol2qm74 6006 6 Z z NN cord-015021-pol2qm74 6006 7 16.3 16.3 CD cord-015021-pol2qm74 6006 8 % % NN cord-015021-pol2qm74 6006 9 ; ; : cord-015021-pol2qm74 6006 10 group group NN cord-015021-pol2qm74 6006 11 2 2 CD cord-015021-pol2qm74 6006 12 65.2 65.2 CD cord-015021-pol2qm74 6006 13 ± ± CD cord-015021-pol2qm74 6006 14 10.9 10.9 CD cord-015021-pol2qm74 6006 15 % % NN cord-015021-pol2qm74 6006 16 ; ; : cord-015021-pol2qm74 6006 17 p p NN cord-015021-pol2qm74 6006 18 < < XX cord-015021-pol2qm74 6006 19 .03 .03 NFP cord-015021-pol2qm74 6006 20 ) ) -RRB- cord-015021-pol2qm74 6006 21 . . . cord-015021-pol2qm74 6007 1 Bypass bypass NN cord-015021-pol2qm74 6007 2 time time NN cord-015021-pol2qm74 6007 3 , , , cord-015021-pol2qm74 6007 4 minimum minimum NN cord-015021-pol2qm74 6007 5 and and CC cord-015021-pol2qm74 6007 6 mean mean VB cord-015021-pol2qm74 6007 7 blood blood NN cord-015021-pol2qm74 6007 8 pressure pressure NN cord-015021-pol2qm74 6007 9 on on IN cord-015021-pol2qm74 6007 10 bypass bypass NN cord-015021-pol2qm74 6007 11 and and CC cord-015021-pol2qm74 6007 12 aortic aortic JJ cord-015021-pol2qm74 6007 13 clamp clamp NN cord-015021-pol2qm74 6007 14 time time NN cord-015021-pol2qm74 6007 15 were be VBD cord-015021-pol2qm74 6007 16 not not RB cord-015021-pol2qm74 6007 17 different different JJ cord-015021-pol2qm74 6007 18 between between IN cord-015021-pol2qm74 6007 19 the the DT cord-015021-pol2qm74 6007 20 groups group NNS cord-015021-pol2qm74 6007 21 . . . cord-015021-pol2qm74 6008 1 Immediately immediately RB cord-015021-pol2qm74 6008 2 postoperatively postoperatively DT cord-015021-pol2qm74 6008 3 ( ( -LRB- cord-015021-pol2qm74 6008 4 pop pop NN cord-015021-pol2qm74 6008 5 ) ) -RRB- cord-015021-pol2qm74 6008 6 , , , cord-015021-pol2qm74 6008 7 the the DT cord-015021-pol2qm74 6008 8 white white JJ cord-015021-pol2qm74 6008 9 blood blood NN cord-015021-pol2qm74 6008 10 count count NN cord-015021-pol2qm74 6008 11 was be VBD cord-015021-pol2qm74 6008 12 elevated elevate VBN cord-015021-pol2qm74 6008 13 ( ( -LRB- cord-015021-pol2qm74 6008 14 group group NN cord-015021-pol2qm74 6008 15 i i PRP cord-015021-pol2qm74 6008 16 : : : cord-015021-pol2qm74 6008 17 15,700 15,700 CD cord-015021-pol2qm74 6009 1 ± ± NNP cord-015021-pol2qm74 6009 2 8,200 8,200 CD cord-015021-pol2qm74 6009 3 / / SYM cord-015021-pol2qm74 6009 4 ui ui NNP cord-015021-pol2qm74 6009 5 ; ; : cord-015021-pol2qm74 6009 6 group group NNP cord-015021-pol2qm74 6009 7 2 2 CD cord-015021-pol2qm74 6009 8 : : : cord-015021-pol2qm74 6010 1 10,200 10,200 CD cord-015021-pol2qm74 6010 2 ~ ~ CD cord-015021-pol2qm74 6010 3 4,400 4,400 CD cord-015021-pol2qm74 6010 4 / / SYM cord-015021-pol2qm74 6010 5 ui ui NNP cord-015021-pol2qm74 6010 6 ; ; : cord-015021-pol2qm74 6010 7 p p NN cord-015021-pol2qm74 6010 8 < < XX cord-015021-pol2qm74 6010 9 .0005 .0005 XX cord-015021-pol2qm74 6010 10 ) ) -RRB- cord-015021-pol2qm74 6011 1 and and CC cord-015021-pol2qm74 6011 2 core core NN cord-015021-pol2qm74 6011 3 temperature temperature NN cord-015021-pol2qm74 6011 4 12 12 CD cord-015021-pol2qm74 6011 5 hours hour NNS cord-015021-pol2qm74 6011 6 pop pop NN cord-015021-pol2qm74 6011 7 was be VBD cord-015021-pol2qm74 6011 8 higher high JJR cord-015021-pol2qm74 6012 1 ( ( -LRB- cord-015021-pol2qm74 6012 2 group group NN cord-015021-pol2qm74 6012 3 i i PRP cord-015021-pol2qm74 6012 4 : : : cord-015021-pol2qm74 6012 5 38.3 38.3 CD cord-015021-pol2qm74 6012 6 7.6 7.6 CD cord-015021-pol2qm74 6012 7 ° ° NN cord-015021-pol2qm74 6012 8 C c NN cord-015021-pol2qm74 6012 9 ; ; : cord-015021-pol2qm74 6012 10 group group NN cord-015021-pol2qm74 6012 11 2 2 CD cord-015021-pol2qm74 6012 12 : : : cord-015021-pol2qm74 6012 13 37.6 37.6 CD cord-015021-pol2qm74 6012 14 ~ ~ CD cord-015021-pol2qm74 6012 15 8.4 8.4 CD cord-015021-pol2qm74 6012 16 ° ° NN cord-015021-pol2qm74 6012 17 C c NN cord-015021-pol2qm74 6012 18 ; ; : cord-015021-pol2qm74 6012 19 p p NN cord-015021-pol2qm74 6012 20 < < XX cord-015021-pol2qm74 6012 21 .004 .004 CD cord-015021-pol2qm74 6012 22 ) ) -RRB- cord-015021-pol2qm74 6012 23 . . . cord-015021-pol2qm74 6013 1 Serum serum NN cord-015021-pol2qm74 6013 2 lactate lactate NN cord-015021-pol2qm74 6013 3 was be VBD cord-015021-pol2qm74 6013 4 already already RB cord-015021-pol2qm74 6013 5 elevated elevate VBN cord-015021-pol2qm74 6013 6 on on IN cord-015021-pol2qm74 6013 7 arrival arrival NN cord-015021-pol2qm74 6013 8 on on IN cord-015021-pol2qm74 6013 9 the the DT cord-015021-pol2qm74 6013 10 ICU ICU NNP cord-015021-pol2qm74 6013 11 pop pop NN cord-015021-pol2qm74 6013 12 ( ( -LRB- cord-015021-pol2qm74 6013 13 group group NN cord-015021-pol2qm74 6013 14 I -PRON- PRP cord-015021-pol2qm74 6013 15 : : : cord-015021-pol2qm74 6013 16 5,0 5,0 CD cord-015021-pol2qm74 6013 17 Z z NN cord-015021-pol2qm74 6013 18 1.9 1.9 CD cord-015021-pol2qm74 6013 19 mmol mmol NNP cord-015021-pol2qm74 6013 20 / / SYM cord-015021-pol2qm74 6013 21 l l NN cord-015021-pol2qm74 6013 22 , , , cord-015021-pol2qm74 6013 23 group group NN cord-015021-pol2qm74 6013 24 2 2 CD cord-015021-pol2qm74 6013 25 : : : cord-015021-pol2qm74 6013 26 2.2 2.2 CD cord-015021-pol2qm74 6013 27 ~ ~ NFP cord-015021-pol2qm74 6013 28 0.9 0.9 CD cord-015021-pol2qm74 6013 29 mmol mmol NN cord-015021-pol2qm74 6013 30 / / SYM cord-015021-pol2qm74 6013 31 l l NN cord-015021-pol2qm74 6013 32 ) ) -RRB- cord-015021-pol2qm74 6013 33 but but CC cord-015021-pol2qm74 6013 34 dropped drop VBD cord-015021-pol2qm74 6013 35 within within IN cord-015021-pol2qm74 6013 36 24 24 CD cord-015021-pol2qm74 6013 37 hours hour NNS cord-015021-pol2qm74 6013 38 ( ( -LRB- cord-015021-pol2qm74 6013 39 p p NN cord-015021-pol2qm74 6013 40 < < XX cord-015021-pol2qm74 6013 41 .0005 .0005 NNP cord-015021-pol2qm74 6013 42 ) ) -RRB- cord-015021-pol2qm74 6013 43 . . . cord-015021-pol2qm74 6014 1 ICU ICU NNP cord-015021-pol2qm74 6014 2 stay stay VBP cord-015021-pol2qm74 6014 3 ( ( -LRB- cord-015021-pol2qm74 6014 4 group group NN cord-015021-pol2qm74 6014 5 i i PRP cord-015021-pol2qm74 6014 6 : : : cord-015021-pol2qm74 6014 7 3.7 3.7 CD cord-015021-pol2qm74 6014 8 ! ! . cord-015021-pol2qm74 6014 9 4.3 4.3 CD cord-015021-pol2qm74 6014 10 ; ; : cord-015021-pol2qm74 6014 11 group group NN cord-015021-pol2qm74 6014 12 2 2 CD cord-015021-pol2qm74 6014 13 : : : cord-015021-pol2qm74 6014 14 1.6 1.6 CD cord-015021-pol2qm74 6014 15 ± ± CD cord-015021-pol2qm74 6014 16 1.9 1.9 CD cord-015021-pol2qm74 6014 17 days day NNS cord-015021-pol2qm74 6014 18 ; ; : cord-015021-pol2qm74 6014 19 p p NN cord-015021-pol2qm74 6014 20 < < XX cord-015021-pol2qm74 6014 21 0.001 0.001 CD cord-015021-pol2qm74 6014 22 ) ) -RRB- cord-015021-pol2qm74 6014 23 and and CC cord-015021-pol2qm74 6014 24 mortality mortality NN cord-015021-pol2qm74 6014 25 over over IN cord-015021-pol2qm74 6014 26 3 3 CD cord-015021-pol2qm74 6014 27 months month NNS cord-015021-pol2qm74 6015 1 ( ( -LRB- cord-015021-pol2qm74 6015 2 group group NN cord-015021-pol2qm74 6015 3 I -PRON- PRP cord-015021-pol2qm74 6015 4 : : : cord-015021-pol2qm74 6015 5 19.1 19.1 CD cord-015021-pol2qm74 6015 6 % % NN cord-015021-pol2qm74 6015 7 ; ; : cord-015021-pol2qm74 6015 8 group group NN cord-015021-pol2qm74 6015 9 2 2 CD cord-015021-pol2qm74 6015 10 : : : cord-015021-pol2qm74 6015 11 3.1 3.1 CD cord-015021-pol2qm74 6015 12 % % NN cord-015021-pol2qm74 6015 13 ; ; : cord-015021-pol2qm74 6015 14 p p NN cord-015021-pol2qm74 6015 15 < < XX cord-015021-pol2qm74 6015 16 .005 .005 NFP cord-015021-pol2qm74 6015 17 ) ) -RRB- cord-015021-pol2qm74 6015 18 were be VBD cord-015021-pol2qm74 6015 19 significant significant JJ cord-015021-pol2qm74 6015 20 higher higher RBR cord-015021-pol2qm74 6015 21 in in IN cord-015021-pol2qm74 6016 1 group group NN cord-015021-pol2qm74 6016 2 i. i. NNP cord-015021-pol2qm74 6016 3 SLS SLS NNP cord-015021-pol2qm74 6016 4 is be VBZ cord-015021-pol2qm74 6016 5 observed observe VBN cord-015021-pol2qm74 6016 6 more more RBR cord-015021-pol2qm74 6016 7 frequently frequently RB cord-015021-pol2qm74 6016 8 in in IN cord-015021-pol2qm74 6016 9 patients patient NNS cord-015021-pol2qm74 6016 10 with with IN cord-015021-pol2qm74 6016 11 preoperative preoperative JJ cord-015021-pol2qm74 6016 12 cardiac cardiac JJ cord-015021-pol2qm74 6016 13 congestion congestion NN cord-015021-pol2qm74 6016 14 and and CC cord-015021-pol2qm74 6016 15 results result NNS cord-015021-pol2qm74 6016 16 in in IN cord-015021-pol2qm74 6016 17 longer long JJR cord-015021-pol2qm74 6016 18 ICU ICU NNP cord-015021-pol2qm74 6016 19 stay stay NN cord-015021-pol2qm74 6016 20 and and CC cord-015021-pol2qm74 6016 21 higher high JJR cord-015021-pol2qm74 6016 22 mortality mortality NN cord-015021-pol2qm74 6016 23 . . . cord-015021-pol2qm74 6017 1 Although although IN cord-015021-pol2qm74 6017 2 intraoperative intraoperative JJ cord-015021-pol2qm74 6017 3 hemodynamics hemodynamic NNS cord-015021-pol2qm74 6017 4 are be VBP cord-015021-pol2qm74 6017 5 similar similar JJ cord-015021-pol2qm74 6017 6 in in IN cord-015021-pol2qm74 6017 7 both both DT cord-015021-pol2qm74 6017 8 groups group NNS cord-015021-pol2qm74 6017 9 , , , cord-015021-pol2qm74 6017 10 the the DT cord-015021-pol2qm74 6017 11 white white JJ cord-015021-pol2qm74 6017 12 blood blood NN cord-015021-pol2qm74 6017 13 count count NN cord-015021-pol2qm74 6017 14 and and CC cord-015021-pol2qm74 6017 15 serum serum NN cord-015021-pol2qm74 6017 16 lactate lactate NN cord-015021-pol2qm74 6017 17 levels level NNS cord-015021-pol2qm74 6017 18 suggest suggest VBP cord-015021-pol2qm74 6017 19 an an DT cord-015021-pol2qm74 6017 20 intraoperative intraoperative JJ cord-015021-pol2qm74 6017 21 cause cause NN cord-015021-pol2qm74 6017 22 for for IN cord-015021-pol2qm74 6017 23 SLS SLS NNP cord-015021-pol2qm74 6017 24 . . . cord-015021-pol2qm74 6018 1 Further further JJ cord-015021-pol2qm74 6018 2 investigations investigation NNS cord-015021-pol2qm74 6018 3 will will MD cord-015021-pol2qm74 6018 4 focus focus VB cord-015021-pol2qm74 6018 5 on on IN cord-015021-pol2qm74 6018 6 possible possible JJ cord-015021-pol2qm74 6018 7 intraoperative intraoperative JJ cord-015021-pol2qm74 6018 8 causes cause NNS cord-015021-pol2qm74 6018 9 of of IN cord-015021-pol2qm74 6018 10 SLS SLS NNP cord-015021-pol2qm74 6018 11 . . . cord-015021-pol2qm74 6019 1 The the DT cord-015021-pol2qm74 6019 2 objectives objective NNS cord-015021-pol2qm74 6019 3 of of IN cord-015021-pol2qm74 6019 4 the the DT cord-015021-pol2qm74 6019 5 study study NN cord-015021-pol2qm74 6019 6 were be VBD cord-015021-pol2qm74 6019 7 to to TO cord-015021-pol2qm74 6019 8 estimate estimate VB cord-015021-pol2qm74 6019 9 the the DT cord-015021-pol2qm74 6019 10 problem problem NN cord-015021-pol2qm74 6019 11 of of IN cord-015021-pol2qm74 6019 12 stress stress NN cord-015021-pol2qm74 6019 13 ulcers ulcer NNS cord-015021-pol2qm74 6019 14 in in IN cord-015021-pol2qm74 6019 15 critically critically RB cord-015021-pol2qm74 6019 16 ill ill JJ cord-015021-pol2qm74 6019 17 patients patient NNS cord-015021-pol2qm74 6019 18 and and CC cord-015021-pol2qm74 6019 19 to to TO cord-015021-pol2qm74 6019 20 compare compare VB cord-015021-pol2qm74 6019 21 Ranitidine Ranitidine NNP cord-015021-pol2qm74 6019 22 and and CC cord-015021-pol2qm74 6019 23 Omeprazole Omeprazole NNP cord-015021-pol2qm74 6019 24 to to TO cord-015021-pol2qm74 6019 25 determine determine VB cord-015021-pol2qm74 6019 26 their -PRON- PRP$ cord-015021-pol2qm74 6019 27 efficacy efficacy NN cord-015021-pol2qm74 6019 28 in in IN cord-015021-pol2qm74 6019 29 the the DT cord-015021-pol2qm74 6019 30 prophylaxis prophylaxis NN cord-015021-pol2qm74 6019 31 of of IN cord-015021-pol2qm74 6019 32 stress stress NN cord-015021-pol2qm74 6019 33 ulcers ulcer NNS cord-015021-pol2qm74 6019 34 . . . cord-015021-pol2qm74 6020 1 33 33 CD cord-015021-pol2qm74 6020 2 patients patient NNS cord-015021-pol2qm74 6020 3 who who WP cord-015021-pol2qm74 6020 4 were be VBD cord-015021-pol2qm74 6020 5 admitted admit VBN cord-015021-pol2qm74 6020 6 to to IN cord-015021-pol2qm74 6020 7 the the DT cord-015021-pol2qm74 6020 8 Intensive Intensive NNP cord-015021-pol2qm74 6020 9 Care Care NNP cord-015021-pol2qm74 6020 10 Units Units NNPS cord-015021-pol2qm74 6020 11 between between IN cord-015021-pol2qm74 6020 12 January January NNP cord-015021-pol2qm74 6020 13 and and CC cord-015021-pol2qm74 6020 14 July July NNP cord-015021-pol2qm74 6020 15 ' ' POS cord-015021-pol2qm74 6020 16 92 92 CD cord-015021-pol2qm74 6020 17 with with IN cord-015021-pol2qm74 6020 18 polytrauma polytrauma NN cord-015021-pol2qm74 6020 19 , , , cord-015021-pol2qm74 6020 20 sepsis sepsis NN cord-015021-pol2qm74 6020 21 or or CC cord-015021-pol2qm74 6020 22 those those DT cord-015021-pol2qm74 6020 23 requiring require VBG cord-015021-pol2qm74 6020 24 ventilatory ventilatory JJ cord-015021-pol2qm74 6020 25 support support NN cord-015021-pol2qm74 6020 26 for for IN cord-015021-pol2qm74 6020 27 more more JJR cord-015021-pol2qm74 6020 28 than than IN cord-015021-pol2qm74 6020 29 48 48 CD cord-015021-pol2qm74 6020 30 hours hour NNS cord-015021-pol2qm74 6020 31 were be VBD cord-015021-pol2qm74 6020 32 selected select VBN cord-015021-pol2qm74 6020 33 for for IN cord-015021-pol2qm74 6020 34 the the DT cord-015021-pol2qm74 6020 35 study study NN cord-015021-pol2qm74 6020 36 . . . cord-015021-pol2qm74 6021 1 The the DT cord-015021-pol2qm74 6021 2 patients patient NNS cord-015021-pol2qm74 6021 3 were be VBD cord-015021-pol2qm74 6021 4 randomized randomize VBN cord-015021-pol2qm74 6021 5 into into IN cord-015021-pol2qm74 6021 6 3 3 CD cord-015021-pol2qm74 6021 7 groups group NNS cord-015021-pol2qm74 6021 8 to to TO cord-015021-pol2qm74 6021 9 receive receive VB cord-015021-pol2qm74 6021 10 Ranitidine Ranitidine NNP cord-015021-pol2qm74 6021 11 , , , cord-015021-pol2qm74 6021 12 Omeprazole Omeprazole NNP cord-015021-pol2qm74 6021 13 or or CC cord-015021-pol2qm74 6021 14 a a DT cord-015021-pol2qm74 6021 15 placebo placebo NN cord-015021-pol2qm74 6021 16 . . . cord-015021-pol2qm74 6022 1 The the DT cord-015021-pol2qm74 6022 2 changes change NNS cord-015021-pol2qm74 6022 3 in in IN cord-015021-pol2qm74 6022 4 gastric gastric JJ cord-015021-pol2qm74 6022 5 pH ph NN cord-015021-pol2qm74 6022 6 were be VBD cord-015021-pol2qm74 6022 7 monitored monitor VBN cord-015021-pol2qm74 6022 8 4 4 CD cord-015021-pol2qm74 6022 9 hourly hourly JJ cord-015021-pol2qm74 6022 10 and and CC cord-015021-pol2qm74 6022 11 the the DT cord-015021-pol2qm74 6022 12 patients patient NNS cord-015021-pol2qm74 6022 13 underwent undergo VBD cord-015021-pol2qm74 6022 14 an an DT cord-015021-pol2qm74 6022 15 upper upper JJ cord-015021-pol2qm74 6022 16 GI GI NNP cord-015021-pol2qm74 6022 17 endoscopy endoscopy NN cord-015021-pol2qm74 6022 18 48 48 CD cord-015021-pol2qm74 6022 19 hours hour NNS cord-015021-pol2qm74 6022 20 after after IN cord-015021-pol2qm74 6022 21 the the DT cord-015021-pol2qm74 6022 22 start start NN cord-015021-pol2qm74 6022 23 of of IN cord-015021-pol2qm74 6022 24 the the DT cord-015021-pol2qm74 6022 25 study study NN cord-015021-pol2qm74 6022 26 to to TO cord-015021-pol2qm74 6022 27 look look VB cord-015021-pol2qm74 6022 28 for for IN cord-015021-pol2qm74 6022 29 stress stress NN cord-015021-pol2qm74 6022 30 ulcers ulcer NNS cord-015021-pol2qm74 6022 31 and and CC cord-015021-pol2qm74 6022 32 hemorrhage hemorrhage NN cord-015021-pol2qm74 6022 33 . . . cord-015021-pol2qm74 6023 1 The the DT cord-015021-pol2qm74 6023 2 drugs drug NNS cord-015021-pol2qm74 6023 3 were be VBD cord-015021-pol2qm74 6023 4 withdrawn withdraw VBN cord-015021-pol2qm74 6023 5 one one CD cord-015021-pol2qm74 6023 6 week week NN cord-015021-pol2qm74 6023 7 after after IN cord-015021-pol2qm74 6023 8 the the DT cord-015021-pol2qm74 6023 9 start start NN cord-015021-pol2qm74 6023 10 of of IN cord-015021-pol2qm74 6023 11 the the DT cord-015021-pol2qm74 6023 12 study study NN cord-015021-pol2qm74 6023 13 . . . cord-015021-pol2qm74 6024 1 Of of IN cord-015021-pol2qm74 6024 2 the the DT cord-015021-pol2qm74 6024 3 33 33 CD cord-015021-pol2qm74 6024 4 patients patient NNS cord-015021-pol2qm74 6024 5 selected select VBN cord-015021-pol2qm74 6024 6 for for IN cord-015021-pol2qm74 6024 7 the the DT cord-015021-pol2qm74 6024 8 study study NN cord-015021-pol2qm74 6024 9 , , , cord-015021-pol2qm74 6024 10 14 14 CD cord-015021-pol2qm74 6024 11 had have VBD cord-015021-pol2qm74 6024 12 undergone undergo VBN cord-015021-pol2qm74 6024 13 cardiac cardiac JJ cord-015021-pol2qm74 6024 14 surgery surgery NN cord-015021-pol2qm74 6024 15 , , , cord-015021-pol2qm74 6024 16 6 6 CD cord-015021-pol2qm74 6024 17 had have VBD cord-015021-pol2qm74 6024 18 polytrauma polytrauma NN cord-015021-pol2qm74 6024 19 and and CC cord-015021-pol2qm74 6024 20 13 13 CD cord-015021-pol2qm74 6024 21 had have VBD cord-015021-pol2qm74 6024 22 sepsis sepsis NN cord-015021-pol2qm74 6024 23 . . . cord-015021-pol2qm74 6025 1 The the DT cord-015021-pol2qm74 6025 2 change change NN cord-015021-pol2qm74 6025 3 in in IN cord-015021-pol2qm74 6025 4 average average JJ cord-015021-pol2qm74 6025 5 pre pre JJ cord-015021-pol2qm74 6025 6 and and CC cord-015021-pol2qm74 6025 7 post post JJ cord-015021-pol2qm74 6025 8 drug drug NN cord-015021-pol2qm74 6025 9 gastric gastric NN cord-015021-pol2qm74 6025 10 pH ph NN cord-015021-pol2qm74 6025 11 was be VBD cord-015021-pol2qm74 6025 12 +1.1 +1.1 CD cord-015021-pol2qm74 6025 13 in in IN cord-015021-pol2qm74 6025 14 the the DT cord-015021-pol2qm74 6025 15 Omeprazole Omeprazole NNP cord-015021-pol2qm74 6025 16 group group NN cord-015021-pol2qm74 6025 17 , , , cord-015021-pol2qm74 6025 18 +0.5 +0.5 NNP cord-015021-pol2qm74 6025 19 in in IN cord-015021-pol2qm74 6025 20 the the DT cord-015021-pol2qm74 6025 21 Ranitidine Ranitidine NNP cord-015021-pol2qm74 6025 22 group group NN cord-015021-pol2qm74 6025 23 and and CC cord-015021-pol2qm74 6025 24 -).9 -).9 NN cord-015021-pol2qm74 6025 25 in in IN cord-015021-pol2qm74 6025 26 the the DT cord-015021-pol2qm74 6025 27 placebo placebo NN cord-015021-pol2qm74 6025 28 group group NN cord-015021-pol2qm74 6025 29 ( ( -LRB- cord-015021-pol2qm74 6025 30 p p NN cord-015021-pol2qm74 6025 31 < < XX cord-015021-pol2qm74 6025 32 0.05 0.05 CD cord-015021-pol2qm74 6025 33 ) ) -RRB- cord-015021-pol2qm74 6025 34 . . . cord-015021-pol2qm74 6026 1 Endoscopic endoscopic JJ cord-015021-pol2qm74 6026 2 evidence evidence NN cord-015021-pol2qm74 6026 3 of of IN cord-015021-pol2qm74 6026 4 stress stress NN cord-015021-pol2qm74 6026 5 ulcers ulcer NNS cord-015021-pol2qm74 6026 6 was be VBD cord-015021-pol2qm74 6026 7 seen see VBN cord-015021-pol2qm74 6026 8 in in IN cord-015021-pol2qm74 6026 9 62 62 CD cord-015021-pol2qm74 6026 10 % % NN cord-015021-pol2qm74 6026 11 of of IN cord-015021-pol2qm74 6026 12 patients patient NNS cord-015021-pol2qm74 6026 13 not not RB cord-015021-pol2qm74 6026 14 on on IN cord-015021-pol2qm74 6026 15 prophylaxis prophylaxis NN cord-015021-pol2qm74 6026 16 , , , cord-015021-pol2qm74 6026 17 18.1 18.1 CD cord-015021-pol2qm74 6026 18 % % NN cord-015021-pol2qm74 6026 19 of of IN cord-015021-pol2qm74 6026 20 those those DT cord-015021-pol2qm74 6026 21 on on IN cord-015021-pol2qm74 6026 22 Omeprazole Omeprazole NNP cord-015021-pol2qm74 6026 23 and and CC cord-015021-pol2qm74 6026 24 54.5 54.5 CD cord-015021-pol2qm74 6026 25 % % NN cord-015021-pol2qm74 6026 26 of of IN cord-015021-pol2qm74 6026 27 those those DT cord-015021-pol2qm74 6026 28 on on IN cord-015021-pol2qm74 6026 29 Ranitidine Ranitidine NNP cord-015021-pol2qm74 6026 30 . . . cord-015021-pol2qm74 6027 1 While while IN cord-015021-pol2qm74 6027 2 all all PDT cord-015021-pol2qm74 6027 3 the the DT cord-015021-pol2qm74 6027 4 patients patient NNS cord-015021-pol2qm74 6027 5 in in IN cord-015021-pol2qm74 6027 6 the the DT cord-015021-pol2qm74 6027 7 placebo placebo NN cord-015021-pol2qm74 6027 8 group group NN cord-015021-pol2qm74 6027 9 who who WP cord-015021-pol2qm74 6027 10 had have VBD cord-015021-pol2qm74 6027 11 stress stress NN cord-015021-pol2qm74 6027 12 ulcers ulcer NNS cord-015021-pol2qm74 6027 13 showed show VBD cord-015021-pol2qm74 6027 14 endoscopic endoscopic JJ cord-015021-pol2qm74 6027 15 evidence evidence NN cord-015021-pol2qm74 6027 16 of of IN cord-015021-pol2qm74 6027 17 hemorrhage hemorrhage NN cord-015021-pol2qm74 6027 18 , , , cord-015021-pol2qm74 6027 19 82 82 CD cord-015021-pol2qm74 6027 20 % % NN cord-015021-pol2qm74 6027 21 of of IN cord-015021-pol2qm74 6027 22 the the DT cord-015021-pol2qm74 6027 23 patients patient NNS cord-015021-pol2qm74 6027 24 with with IN cord-015021-pol2qm74 6027 25 ulcers ulcer NNS cord-015021-pol2qm74 6027 26 in in IN cord-015021-pol2qm74 6027 27 the the DT cord-015021-pol2qm74 6027 28 Ranitidine Ranitidine NNP cord-015021-pol2qm74 6027 29 group group NN cord-015021-pol2qm74 6027 30 and and CC cord-015021-pol2qm74 6027 31 none none NN cord-015021-pol2qm74 6027 32 of of IN cord-015021-pol2qm74 6027 33 the the DT cord-015021-pol2qm74 6027 34 patients patient NNS cord-015021-pol2qm74 6027 35 with with IN cord-015021-pol2qm74 6027 36 ulcers ulcer NNS cord-015021-pol2qm74 6027 37 in in IN cord-015021-pol2qm74 6027 38 the the DT cord-015021-pol2qm74 6027 39 Omeprazole Omeprazole NNP cord-015021-pol2qm74 6027 40 group group NN cord-015021-pol2qm74 6027 41 showed show VBD cord-015021-pol2qm74 6027 42 hemorrhage hemorrhage NN cord-015021-pol2qm74 6028 1 ( ( -LRB- cord-015021-pol2qm74 6028 2 p p NN cord-015021-pol2qm74 6028 3 < < XX cord-015021-pol2qm74 6028 4 0.01 0.01 CD cord-015021-pol2qm74 6028 5 ) ) -RRB- cord-015021-pol2qm74 6028 6 . . . cord-015021-pol2qm74 6029 1 In in IN cord-015021-pol2qm74 6029 2 critically critically RB cord-015021-pol2qm74 6029 3 ill ill JJ cord-015021-pol2qm74 6029 4 patients patient NNS cord-015021-pol2qm74 6029 5 the the DT cord-015021-pol2qm74 6029 6 incidence incidence NN cord-015021-pol2qm74 6029 7 of of IN cord-015021-pol2qm74 6029 8 stress stress NN cord-015021-pol2qm74 6029 9 ulceration ulceration NN cord-015021-pol2qm74 6029 10 is be VBZ cord-015021-pol2qm74 6029 11 high high JJ cord-015021-pol2qm74 6029 12 . . . cord-015021-pol2qm74 6030 1 An an DT cord-015021-pol2qm74 6030 2 alkaline alkaline JJ cord-015021-pol2qm74 6030 3 gastric gastric NN cord-015021-pol2qm74 6030 4 pH ph NN cord-015021-pol2qm74 6030 5 is be VBZ cord-015021-pol2qm74 6030 6 protective protective JJ cord-015021-pol2qm74 6030 7 against against IN cord-015021-pol2qm74 6030 8 stress stress NN cord-015021-pol2qm74 6030 9 ulcers ulcer NNS cord-015021-pol2qm74 6030 10 . . . cord-015021-pol2qm74 6031 1 Omeprazole omeprazole NN cord-015021-pol2qm74 6031 2 when when WRB cord-015021-pol2qm74 6031 3 used use VBN cord-015021-pol2qm74 6031 4 for for IN cord-015021-pol2qm74 6031 5 prophylaxis prophylaxis NN cord-015021-pol2qm74 6031 6 against against IN cord-015021-pol2qm74 6031 7 stress stress NN cord-015021-pol2qm74 6031 8 ulcers ulcer NNS cord-015021-pol2qm74 6031 9 in in IN cord-015021-pol2qm74 6031 10 critically critically RB cord-015021-pol2qm74 6031 11 ill ill JJ cord-015021-pol2qm74 6031 12 patients patient NNS cord-015021-pol2qm74 6031 13 or or CC cord-015021-pol2qm74 6031 14 those those DT cord-015021-pol2qm74 6031 15 on on IN cord-015021-pol2qm74 6031 16 short short JJ cord-015021-pol2qm74 6031 17 term term NN cord-015021-pol2qm74 6031 18 ventilation ventilation NN cord-015021-pol2qm74 6031 19 will will MD cord-015021-pol2qm74 6031 20 reduce reduce VB cord-015021-pol2qm74 6031 21 the the DT cord-015021-pol2qm74 6031 22 incidence incidence NN cord-015021-pol2qm74 6031 23 of of IN cord-015021-pol2qm74 6031 24 formation formation NN cord-015021-pol2qm74 6031 25 and and CC cord-015021-pol2qm74 6031 26 hemorrhage hemorrhage NN cord-015021-pol2qm74 6031 27 from from IN cord-015021-pol2qm74 6031 28 stress stress NN cord-015021-pol2qm74 6031 29 ulcers ulcer NNS cord-015021-pol2qm74 6031 30 . . . cord-015021-pol2qm74 6032 1 The the DT cord-015021-pol2qm74 6032 2 early early JJ cord-015021-pol2qm74 6032 3 and and CC cord-015021-pol2qm74 6032 4 accurate accurate JJ cord-015021-pol2qm74 6032 5 diagnosis diagnosis NN cord-015021-pol2qm74 6032 6 of of IN cord-015021-pol2qm74 6032 7 sepsis sepsis NN cord-015021-pol2qm74 6032 8 is be VBZ cord-015021-pol2qm74 6032 9 of of IN cord-015021-pol2qm74 6032 10 key key JJ cord-015021-pol2qm74 6032 11 importance importance NN cord-015021-pol2qm74 6032 12 for for IN cord-015021-pol2qm74 6032 13 critically critically RB cord-015021-pol2qm74 6032 14 ill ill JJ cord-015021-pol2qm74 6032 15 patients patient NNS cord-015021-pol2qm74 6032 16 survival survival NN cord-015021-pol2qm74 6032 17 . . . cord-015021-pol2qm74 6033 1 Many many JJ cord-015021-pol2qm74 6033 2 studies study NNS cord-015021-pol2qm74 6033 3 have have VBP cord-015021-pol2qm74 6033 4 shown show VBN cord-015021-pol2qm74 6033 5 that that IN cord-015021-pol2qm74 6033 6 tumor tumor NN cord-015021-pol2qm74 6033 7 necrosis necrosis NN cord-015021-pol2qm74 6033 8 factor factor NN cord-015021-pol2qm74 6034 1 ~x ~x NNP cord-015021-pol2qm74 6035 1 ( ( -LRB- cord-015021-pol2qm74 6035 2 TNF TNF NNP cord-015021-pol2qm74 6035 3 ~ ~ NFP cord-015021-pol2qm74 6035 4 ) ) -RRB- cord-015021-pol2qm74 6035 5 and and CC cord-015021-pol2qm74 6035 6 interleukin-6 interleukin-6 NNP cord-015021-pol2qm74 6035 7 ( ( -LRB- cord-015021-pol2qm74 6035 8 IL-6 IL-6 NNP cord-015021-pol2qm74 6035 9 ) ) -RRB- cord-015021-pol2qm74 6035 10 are be VBP cord-015021-pol2qm74 6035 11 mediators mediator NNS cord-015021-pol2qm74 6035 12 of of IN cord-015021-pol2qm74 6035 13 the the DT cord-015021-pol2qm74 6035 14 inflammatory inflammatory JJ cord-015021-pol2qm74 6035 15 response response NN cord-015021-pol2qm74 6035 16 in in IN cord-015021-pol2qm74 6035 17 sepsis sepsis NN cord-015021-pol2qm74 6035 18 . . . cord-015021-pol2qm74 6036 1 Bacterial bacterial JJ cord-015021-pol2qm74 6036 2 antigens antigen NNS cord-015021-pol2qm74 6036 3 interact interact VBP cord-015021-pol2qm74 6036 4 also also RB cord-015021-pol2qm74 6036 5 with with IN cord-015021-pol2qm74 6036 6 antigen antigen NN cord-015021-pol2qm74 6036 7 specific specific JJ cord-015021-pol2qm74 6036 8 T T NNP cord-015021-pol2qm74 6036 9 cell cell NN cord-015021-pol2qm74 6036 10 receptors receptor NNS cord-015021-pol2qm74 6036 11 and and CC cord-015021-pol2qm74 6036 12 the the DT cord-015021-pol2qm74 6036 13 activation activation NN cord-015021-pol2qm74 6036 14 of of IN cord-015021-pol2qm74 6036 15 T T NNP cord-015021-pol2qm74 6036 16 ceils ceils NNP cord-015021-pol2qm74 6036 17 takes take VBZ cord-015021-pol2qm74 6036 18 place place NN cord-015021-pol2qm74 6036 19 . . . cord-015021-pol2qm74 6037 1 Activated activate VBN cord-015021-pol2qm74 6037 2 T T NNP cord-015021-pol2qm74 6037 3 cells cell NNS cord-015021-pol2qm74 6037 4 release release VBP cord-015021-pol2qm74 6037 5 soluble soluble JJ cord-015021-pol2qm74 6037 6 interteuldn-2 interteuldn-2 NNP cord-015021-pol2qm74 6037 7 receptors receptor NNS cord-015021-pol2qm74 6037 8 ( ( -LRB- cord-015021-pol2qm74 6037 9 sIL-2R sIL-2R NNP cord-015021-pol2qm74 6037 10 ) ) -RRB- cord-015021-pol2qm74 6037 11 . . . cord-015021-pol2qm74 6038 1 The the DT cord-015021-pol2qm74 6038 2 aim aim NN cord-015021-pol2qm74 6038 3 of of IN cord-015021-pol2qm74 6038 4 this this DT cord-015021-pol2qm74 6038 5 study study NN cord-015021-pol2qm74 6038 6 was be VBD cord-015021-pol2qm74 6038 7 to to TO cord-015021-pol2qm74 6038 8 evaluate evaluate VB cord-015021-pol2qm74 6038 9 : : : cord-015021-pol2qm74 6038 10 the the DT cord-015021-pol2qm74 6038 11 significance significance NN cord-015021-pol2qm74 6038 12 ofTNF oftnf IN cord-015021-pol2qm74 6039 1 c~ c~ XX cord-015021-pol2qm74 6039 2 , , , cord-015021-pol2qm74 6039 3 IL-6 IL-6 NNP cord-015021-pol2qm74 6039 4 and and CC cord-015021-pol2qm74 6039 5 slL-2R slL-2R NNP cord-015021-pol2qm74 6039 6 in in IN cord-015021-pol2qm74 6039 7 the the DT cord-015021-pol2qm74 6039 8 diagnosis diagnosis NN cord-015021-pol2qm74 6039 9 of of IN cord-015021-pol2qm74 6039 10 bacterial bacterial JJ cord-015021-pol2qm74 6039 11 sepsis sepsis NN cord-015021-pol2qm74 6039 12 and and CC cord-015021-pol2qm74 6039 13 to to TO cord-015021-pol2qm74 6039 14 evaluate evaluate VB cord-015021-pol2qm74 6039 15 the the DT cord-015021-pol2qm74 6039 16 correlation correlation NN cord-015021-pol2qm74 6039 17 of of IN cord-015021-pol2qm74 6039 18 clinical clinical JJ cord-015021-pol2qm74 6039 19 and and CC cord-015021-pol2qm74 6039 20 laboratory laboratory NN cord-015021-pol2qm74 6039 21 parameters parameter NNS cord-015021-pol2qm74 6039 22 with with IN cord-015021-pol2qm74 6039 23 serum serum NN cord-015021-pol2qm74 6039 24 levels level NNS cord-015021-pol2qm74 6039 25 of of IN cord-015021-pol2qm74 6039 26 TNF TNF NNP cord-015021-pol2qm74 6039 27 ~x ~x NNP cord-015021-pol2qm74 6039 28 , , , cord-015021-pol2qm74 6039 29 IL-6 IL-6 NNP cord-015021-pol2qm74 6039 30 and and CC cord-015021-pol2qm74 6039 31 slL-2R. slL-2R. NNP cord-015021-pol2qm74 6040 1 We -PRON- PRP cord-015021-pol2qm74 6040 2 examined examine VBD cord-015021-pol2qm74 6040 3 19 19 CD cord-015021-pol2qm74 6040 4 patients patient NNS cord-015021-pol2qm74 6040 5 with with IN cord-015021-pol2qm74 6040 6 clinical clinical JJ cord-015021-pol2qm74 6040 7 signs sign NNS cord-015021-pol2qm74 6040 8 of of IN cord-015021-pol2qm74 6040 9 sepsis sepsis NN cord-015021-pol2qm74 6040 10 treated treat VBN cord-015021-pol2qm74 6040 11 in in IN cord-015021-pol2qm74 6040 12 the the DT cord-015021-pol2qm74 6040 13 intensive intensive JJ cord-015021-pol2qm74 6040 14 care care NN cord-015021-pol2qm74 6040 15 units unit NNS cord-015021-pol2qm74 6040 16 of of IN cord-015021-pol2qm74 6040 17 University University NNP cord-015021-pol2qm74 6040 18 Medical Medical NNP cord-015021-pol2qm74 6040 19 Centre Centre NNP cord-015021-pol2qm74 6040 20 Ljubljana Ljubljana NNP cord-015021-pol2qm74 6040 21 . . . cord-015021-pol2qm74 6041 1 Venous venous JJ cord-015021-pol2qm74 6041 2 blood blood NN cord-015021-pol2qm74 6041 3 was be VBD cord-015021-pol2qm74 6041 4 drawn draw VBN cord-015021-pol2qm74 6041 5 from from IN cord-015021-pol2qm74 6041 6 each each DT cord-015021-pol2qm74 6041 7 patient patient NN cord-015021-pol2qm74 6041 8 within within IN cord-015021-pol2qm74 6041 9 24 24 CD cord-015021-pol2qm74 6041 10 hours hour NNS cord-015021-pol2qm74 6041 11 after after IN cord-015021-pol2qm74 6041 12 the the DT cord-015021-pol2qm74 6041 13 first first JJ cord-015021-pol2qm74 6041 14 clinical clinical JJ cord-015021-pol2qm74 6041 15 signs sign NNS cord-015021-pol2qm74 6041 16 of of IN cord-015021-pol2qm74 6041 17 sepsis sepsis NN cord-015021-pol2qm74 6041 18 . . . cord-015021-pol2qm74 6042 1 Clinical clinical JJ cord-015021-pol2qm74 6042 2 data datum NNS cord-015021-pol2qm74 6042 3 ( ( -LRB- cord-015021-pol2qm74 6042 4 body body NN cord-015021-pol2qm74 6042 5 temperature temperature NN cord-015021-pol2qm74 6042 6 , , , cord-015021-pol2qm74 6042 7 blood blood NN cord-015021-pol2qm74 6042 8 pressure pressure NN cord-015021-pol2qm74 6042 9 ) ) -RRB- cord-015021-pol2qm74 6042 10 , , , cord-015021-pol2qm74 6042 11 laboratory laboratory NN cord-015021-pol2qm74 6042 12 dam dam NN cord-015021-pol2qm74 6042 13 ( ( -LRB- cord-015021-pol2qm74 6042 14 peripheral peripheral JJ cord-015021-pol2qm74 6042 15 white white JJ cord-015021-pol2qm74 6042 16 blood blood NN cord-015021-pol2qm74 6042 17 cell cell NN cord-015021-pol2qm74 6042 18 count count NN cord-015021-pol2qm74 6042 19 with with IN cord-015021-pol2qm74 6042 20 differential differential JJ cord-015021-pol2qm74 6042 21 , , , cord-015021-pol2qm74 6042 22 platelet platelet NN cord-015021-pol2qm74 6042 23 count count NN cord-015021-pol2qm74 6042 24 , , , cord-015021-pol2qm74 6042 25 C c NN cord-015021-pol2qm74 6042 26 - - HYPH cord-015021-pol2qm74 6042 27 reactive reactive JJ cord-015021-pol2qm74 6042 28 protein protein NN cord-015021-pol2qm74 6042 29 ) ) -RRB- cord-015021-pol2qm74 6042 30 , , , cord-015021-pol2qm74 6042 31 and and CC cord-015021-pol2qm74 6042 32 quantitative quantitative JJ cord-015021-pol2qm74 6042 33 blood blood NN cord-015021-pol2qm74 6042 34 cultures culture NNS cord-015021-pol2qm74 6042 35 were be VBD cord-015021-pol2qm74 6042 36 recorded record VBN cord-015021-pol2qm74 6042 37 . . . cord-015021-pol2qm74 6043 1 Serum serum NN cord-015021-pol2qm74 6043 2 levels level NNS cord-015021-pol2qm74 6043 3 of of IN cord-015021-pol2qm74 6043 4 TNF TNF NNP cord-015021-pol2qm74 6044 1 c~ c~ XX cord-015021-pol2qm74 6044 2 , , , cord-015021-pol2qm74 6045 1 11,-6 11,-6 NNP cord-015021-pol2qm74 6045 2 and and CC cord-015021-pol2qm74 6045 3 sIL-2R sIL-2R NNP cord-015021-pol2qm74 6045 4 were be VBD cord-015021-pol2qm74 6045 5 measured measure VBN cord-015021-pol2qm74 6045 6 in in IN cord-015021-pol2qm74 6045 7 19 19 CD cord-015021-pol2qm74 6045 8 septic septic JJ cord-015021-pol2qm74 6045 9 patients patient NNS cord-015021-pol2qm74 6045 10 and and CC cord-015021-pol2qm74 6045 11 in in IN cord-015021-pol2qm74 6045 12 20 20 CD cord-015021-pol2qm74 6045 13 adult adult NN cord-015021-pol2qm74 6045 14 healthy healthy JJ cord-015021-pol2qm74 6045 15 controls control NNS cord-015021-pol2qm74 6045 16 . . . cord-015021-pol2qm74 6046 1 TNF TNF NNP cord-015021-pol2qm74 6046 2 ct ct NNP cord-015021-pol2qm74 6046 3 , , , cord-015021-pol2qm74 6046 4 IL-6 IL-6 NNP cord-015021-pol2qm74 6046 5 and and CC cord-015021-pol2qm74 6046 6 sIL-2R sIL-2R NNP cord-015021-pol2qm74 6046 7 serum serum NN cord-015021-pol2qm74 6046 8 levels level NNS cord-015021-pol2qm74 6046 9 were be VBD cord-015021-pol2qm74 6046 10 measured measure VBN cord-015021-pol2qm74 6046 11 by by IN cord-015021-pol2qm74 6046 12 commercially commercially RB cord-015021-pol2qm74 6046 13 available available JJ cord-015021-pol2qm74 6046 14 RIA RIA NNP cord-015021-pol2qm74 6046 15 and and CC cord-015021-pol2qm74 6046 16 ELISA ELISA NNP cord-015021-pol2qm74 6047 1 ( ( -LRB- cord-015021-pol2qm74 6047 2 Amersharn Amersharn NNP cord-015021-pol2qm74 6047 3 and and CC cord-015021-pol2qm74 6047 4 Eurogenetics Eurogenetics NNP cord-015021-pol2qm74 6047 5 ) ) -RRB- cord-015021-pol2qm74 6047 6 kits kit NNS cord-015021-pol2qm74 6047 7 . . . cord-015021-pol2qm74 6048 1 The the DT cord-015021-pol2qm74 6048 2 differences difference NNS cord-015021-pol2qm74 6048 3 in in IN cord-015021-pol2qm74 6048 4 serttm serttm NN cord-015021-pol2qm74 6048 5 levels level NNS cord-015021-pol2qm74 6048 6 of of IN cord-015021-pol2qm74 6048 7 TNF TNF NNP cord-015021-pol2qm74 6048 8 ~ ~ NFP cord-015021-pol2qm74 6048 9 , , , cord-015021-pol2qm74 6048 10 IL-6 IL-6 NNP cord-015021-pol2qm74 6048 11 and and CC cord-015021-pol2qm74 6048 12 sIL-2R sIL-2R NNS cord-015021-pol2qm74 6048 13 between between IN cord-015021-pol2qm74 6048 14 healthy healthy JJ cord-015021-pol2qm74 6048 15 control control NN cord-015021-pol2qm74 6048 16 and and CC cord-015021-pol2qm74 6048 17 patients patient NNS cord-015021-pol2qm74 6048 18 and and CC cord-015021-pol2qm74 6048 19 correlation correlation NN cord-015021-pol2qm74 6048 20 between between IN cord-015021-pol2qm74 6048 21 clinical clinical JJ cord-015021-pol2qm74 6048 22 and and CC cord-015021-pol2qm74 6048 23 laboratory laboratory NN cord-015021-pol2qm74 6048 24 parameters parameter NNS cord-015021-pol2qm74 6048 25 were be VBD cord-015021-pol2qm74 6048 26 calculated calculate VBN cord-015021-pol2qm74 6048 27 . . . cord-015021-pol2qm74 6049 1 We -PRON- PRP cord-015021-pol2qm74 6049 2 found find VBD cord-015021-pol2qm74 6049 3 that that IN cord-015021-pol2qm74 6049 4 only only RB cord-015021-pol2qm74 6049 5 slL-2R sll-2r JJ cord-015021-pol2qm74 6049 6 serum serum NN cord-015021-pol2qm74 6049 7 levels level NNS cord-015021-pol2qm74 6049 8 were be VBD cord-015021-pol2qm74 6049 9 significantly significantly RB cord-015021-pol2qm74 6049 10 ( ( -LRB- cord-015021-pol2qm74 6049 11 p<0.005 p<0.005 JJ cord-015021-pol2qm74 6049 12 , , , cord-015021-pol2qm74 6049 13 Student Student NNP cord-015021-pol2qm74 6049 14 t t NN cord-015021-pol2qm74 6049 15 test test NN cord-015021-pol2qm74 6049 16 ) ) -RRB- cord-015021-pol2qm74 6049 17 increased increase VBD cord-015021-pol2qm74 6049 18 in in IN cord-015021-pol2qm74 6049 19 patients patient NNS cord-015021-pol2qm74 6049 20 in in IN cord-015021-pol2qm74 6049 21 comparison comparison NN cord-015021-pol2qm74 6049 22 with with IN cord-015021-pol2qm74 6049 23 healthy healthy JJ cord-015021-pol2qm74 6049 24 controls control NNS cord-015021-pol2qm74 6049 25 . . . cord-015021-pol2qm74 6050 1 Of of IN cord-015021-pol2qm74 6050 2 all all DT cord-015021-pol2qm74 6050 3 indicators indicator NNS cord-015021-pol2qm74 6050 4 of of IN cord-015021-pol2qm74 6050 5 sepsis sepsis NN cord-015021-pol2qm74 6050 6 that that WDT cord-015021-pol2qm74 6050 7 we -PRON- PRP cord-015021-pol2qm74 6050 8 compared compare VBD cord-015021-pol2qm74 6050 9 , , , cord-015021-pol2qm74 6050 10 only only JJ cord-015021-pol2qm74 6050 11 hypotension hypotension NN cord-015021-pol2qm74 6050 12 was be VBD cord-015021-pol2qm74 6050 13 significantly significantly RB cord-015021-pol2qm74 6050 14 correlated correlate VBN cord-015021-pol2qm74 6050 15 with with IN cord-015021-pol2qm74 6050 16 TNF TNF NNP cord-015021-pol2qm74 6050 17 ~x ~x NNP cord-015021-pol2qm74 6050 18 levels level NNS cord-015021-pol2qm74 6050 19 and and CC cord-015021-pol2qm74 6050 20 leukocytosis leukocytosis NN cord-015021-pol2qm74 6050 21 with with IN cord-015021-pol2qm74 6050 22 ] ] -RRB- cord-015021-pol2qm74 6050 23 1,-6 1,-6 CD cord-015021-pol2qm74 6050 24 levels level NNS cord-015021-pol2qm74 6050 25 . . . cord-015021-pol2qm74 6051 1 We -PRON- PRP cord-015021-pol2qm74 6051 2 conclude conclude VBP cord-015021-pol2qm74 6051 3 that that IN cord-015021-pol2qm74 6051 4 only only RB cord-015021-pol2qm74 6051 5 the the DT cord-015021-pol2qm74 6051 6 increased increase VBN cord-015021-pol2qm74 6051 7 serum serum NN cord-015021-pol2qm74 6051 8 sIL-2R sil-2r NN cord-015021-pol2qm74 6051 9 levels level NNS cord-015021-pol2qm74 6051 10 were be VBD cord-015021-pol2qm74 6051 11 predictive predictive JJ cord-015021-pol2qm74 6051 12 of of IN cord-015021-pol2qm74 6051 13 bacterial bacterial JJ cord-015021-pol2qm74 6051 14 sepsis sepsis NN cord-015021-pol2qm74 6051 15 within within IN cord-015021-pol2qm74 6051 16 24 24 CD cord-015021-pol2qm74 6051 17 hours hour NNS cord-015021-pol2qm74 6051 18 after after IN cord-015021-pol2qm74 6051 19 the the DT cord-015021-pol2qm74 6051 20 first first JJ cord-015021-pol2qm74 6051 21 septic septic JJ cord-015021-pol2qm74 6051 22 signs sign NNS cord-015021-pol2qm74 6051 23 . . . cord-015021-pol2qm74 6052 1 TNF TNF NNP cord-015021-pol2qm74 6052 2 c~ c~ NNP cord-015021-pol2qm74 6052 3 and and CC cord-015021-pol2qm74 6052 4 IL-6 IL-6 NNP cord-015021-pol2qm74 6052 5 levels level NNS cord-015021-pol2qm74 6052 6 were be VBD cord-015021-pol2qm74 6052 7 not not RB cord-015021-pol2qm74 6052 8 significantly significantly RB cord-015021-pol2qm74 6052 9 increased increase VBN cord-015021-pol2qm74 6052 10 at at IN cord-015021-pol2qm74 6052 11 that that DT cord-015021-pol2qm74 6052 12 time time NN cord-015021-pol2qm74 6052 13 in in IN cord-015021-pol2qm74 6052 14 lifts lift VBZ cord-015021-pol2qm74 6052 15 small small JJ cord-015021-pol2qm74 6052 16 group group NN cord-015021-pol2qm74 6052 17 of of IN cord-015021-pol2qm74 6052 18 patients patient NNS cord-015021-pol2qm74 6052 19 . . . cord-015021-pol2qm74 6053 1 In in IN cord-015021-pol2qm74 6053 2 order order NN cord-015021-pol2qm74 6053 3 to to TO cord-015021-pol2qm74 6053 4 create create VB cord-015021-pol2qm74 6053 5 high high JJ cord-015021-pol2qm74 6053 6 precision precision NN cord-015021-pol2qm74 6053 7 prognostic prognostic JJ cord-015021-pol2qm74 6053 8 system system NN cord-015021-pol2qm74 6053 9 for for IN cord-015021-pol2qm74 6053 10 patients patient NNS cord-015021-pol2qm74 6053 11 with with IN cord-015021-pol2qm74 6053 12 sepsis sepsis NN cord-015021-pol2qm74 6053 13 and and CC cord-015021-pol2qm74 6053 14 septic septic JJ cord-015021-pol2qm74 6053 15 shock shock NN cord-015021-pol2qm74 6053 16 we -PRON- PRP cord-015021-pol2qm74 6053 17 have have VBP cord-015021-pol2qm74 6053 18 made make VBN cord-015021-pol2qm74 6053 19 prospective prospective JJ cord-015021-pol2qm74 6053 20 and and CC cord-015021-pol2qm74 6053 21 retrospective retrospective JJ cord-015021-pol2qm74 6053 22 analis anali NNS cord-015021-pol2qm74 6053 23 of of IN cord-015021-pol2qm74 6053 24 200 200 CD cord-015021-pol2qm74 6053 25 cases case NNS cord-015021-pol2qm74 6053 26 of of IN cord-015021-pol2qm74 6053 27 sepsis sepsis NN cord-015021-pol2qm74 6053 28 . . . cord-015021-pol2qm74 6054 1 Patients patient NNS cord-015021-pol2qm74 6054 2 were be VBD cord-015021-pol2qm74 6054 3 included include VBN cord-015021-pol2qm74 6054 4 in in IN cord-015021-pol2qm74 6054 5 this this DT cord-015021-pol2qm74 6054 6 analis anali NNS cord-015021-pol2qm74 6054 7 according accord VBG cord-015021-pol2qm74 6054 8 Bone Bone NNP cord-015021-pol2qm74 6054 9 's 's POS cord-015021-pol2qm74 6054 10 criterions criterion NNS cord-015021-pol2qm74 6054 11 of of IN cord-015021-pol2qm74 6054 12 sepsis sepsis NN cord-015021-pol2qm74 6054 13 . . . cord-015021-pol2qm74 6055 1 Comparing compare VBG cord-015021-pol2qm74 6055 2 with with IN cord-015021-pol2qm74 6055 3 APACHE APACHE NNP cord-015021-pol2qm74 6055 4 - - HYPH cord-015021-pol2qm74 6055 5 H H NNP cord-015021-pol2qm74 6055 6 , , , cord-015021-pol2qm74 6055 7 we -PRON- PRP cord-015021-pol2qm74 6055 8 have have VBP cord-015021-pol2qm74 6055 9 excluded exclude VBN cord-015021-pol2qm74 6055 10 such such JJ cord-015021-pol2qm74 6055 11 phisiologic phisiologic JJ cord-015021-pol2qm74 6055 12 variables variable NNS cord-015021-pol2qm74 6055 13 as as IN cord-015021-pol2qm74 6055 14 : : : cord-015021-pol2qm74 6055 15 temperature temperature NN cord-015021-pol2qm74 6055 16 , , , cord-015021-pol2qm74 6055 17 Na+ na+ NN cord-015021-pol2qm74 6055 18 , , , cord-015021-pol2qm74 6055 19 K+ K+ NNP cord-015021-pol2qm74 6055 20 , , , cord-015021-pol2qm74 6055 21 } } -RRB- cord-015021-pol2qm74 6055 22 It -PRON- PRP cord-015021-pol2qm74 6055 23 , , , cord-015021-pol2qm74 6055 24 pH pH NNP cord-015021-pol2qm74 6055 25 , , , cord-015021-pol2qm74 6055 26 which which WDT cord-015021-pol2qm74 6055 27 had have VBD cord-015021-pol2qm74 6055 28 a a DT cord-015021-pol2qm74 6055 29 little little JJ cord-015021-pol2qm74 6055 30 influence influence NN cord-015021-pol2qm74 6055 31 on on IN cord-015021-pol2qm74 6055 32 prognos prognos NNP cord-015021-pol2qm74 6055 33 of of IN cord-015021-pol2qm74 6055 34 illness illness NN cord-015021-pol2qm74 6055 35 . . . cord-015021-pol2qm74 6056 1 We -PRON- PRP cord-015021-pol2qm74 6056 2 have have VBP cord-015021-pol2qm74 6056 3 added add VBN cord-015021-pol2qm74 6056 4 the the DT cord-015021-pol2qm74 6056 5 other other JJ cord-015021-pol2qm74 6056 6 , , , cord-015021-pol2qm74 6056 7 more more RBR cord-015021-pol2qm74 6056 8 important important JJ cord-015021-pol2qm74 6056 9 variables variable NNS cord-015021-pol2qm74 6056 10 : : : cord-015021-pol2qm74 6056 11 biilirubin biilirubin NNP cord-015021-pol2qm74 6056 12 , , , cord-015021-pol2qm74 6056 13 plateles platele NNS cord-015021-pol2qm74 6056 14 , , , cord-015021-pol2qm74 6056 15 PTI PTI NNP cord-015021-pol2qm74 6056 16 . . . cord-015021-pol2qm74 6057 1 We -PRON- PRP cord-015021-pol2qm74 6057 2 took take VBD cord-015021-pol2qm74 6057 3 into into IN cord-015021-pol2qm74 6057 4 account account NN cord-015021-pol2qm74 6057 5 : : : cord-015021-pol2qm74 6057 6 the the DT cord-015021-pol2qm74 6057 7 seat seat NN cord-015021-pol2qm74 6057 8 arrangement arrangement NN cord-015021-pol2qm74 6057 9 , , , cord-015021-pol2qm74 6057 10 methods method NNS cord-015021-pol2qm74 6057 11 of of IN cord-015021-pol2qm74 6057 12 respiratory respiratory JJ cord-015021-pol2qm74 6057 13 support support NN cord-015021-pol2qm74 6057 14 , , , cord-015021-pol2qm74 6057 15 comorbid comorbid NN cord-015021-pol2qm74 6057 16 conditions condition NNS cord-015021-pol2qm74 6057 17 as as IN cord-015021-pol2qm74 6057 18 : : : cord-015021-pol2qm74 6057 19 caneer caneer NNP cord-015021-pol2qm74 6057 20 , , , cord-015021-pol2qm74 6057 21 diabets diabets NNPS cord-015021-pol2qm74 6057 22 , , , cord-015021-pol2qm74 6057 23 obersity obersity NN cord-015021-pol2qm74 6057 24 . . . cord-015021-pol2qm74 6058 1 In in IN cord-015021-pol2qm74 6058 2 general general JJ cord-015021-pol2qm74 6058 3 new new JJ cord-015021-pol2qm74 6058 4 score score NN cord-015021-pol2qm74 6058 5 has have VBZ cord-015021-pol2qm74 6058 6 5 5 CD cord-015021-pol2qm74 6058 7 headings heading NNS cord-015021-pol2qm74 6058 8 : : : cord-015021-pol2qm74 6058 9 -physiologic -physiologic NN cord-015021-pol2qm74 6058 10 variables variable NNS cord-015021-pol2qm74 6058 11 , , , cord-015021-pol2qm74 6058 12 -age -age '' cord-015021-pol2qm74 6058 13 , , , cord-015021-pol2qm74 6058 14 -seat -seat CD cord-015021-pol2qm74 6058 15 arrangement arrangement NN cord-015021-pol2qm74 6058 16 , , , cord-015021-pol2qm74 6058 17 -chronic -chronic : cord-015021-pol2qm74 6058 18 comorbid comorbid NN cord-015021-pol2qm74 6058 19 conditions condition NNS cord-015021-pol2qm74 6058 20 , , , cord-015021-pol2qm74 6058 21 -methods -methods RB cord-015021-pol2qm74 6058 22 of of IN cord-015021-pol2qm74 6058 23 respiratory respiratory JJ cord-015021-pol2qm74 6058 24 support support NN cord-015021-pol2qm74 6058 25 . . . cord-015021-pol2qm74 6059 1 ROC ROC NNP cord-015021-pol2qm74 6059 2 -analis -anali NNS cord-015021-pol2qm74 6059 3 have have VBP cord-015021-pol2qm74 6059 4 showed show VBN cord-015021-pol2qm74 6059 5 a a DT cord-015021-pol2qm74 6059 6 greater great JJR cord-015021-pol2qm74 6059 7 precision precision NN cord-015021-pol2qm74 6059 8 of of IN cord-015021-pol2qm74 6059 9 our -PRON- PRP$ cord-015021-pol2qm74 6059 10 score score NN cord-015021-pol2qm74 6059 11 , , , cord-015021-pol2qm74 6059 12 compared compare VBN cord-015021-pol2qm74 6059 13 with with IN cord-015021-pol2qm74 6059 14 APACHE APACHE NNP cord-015021-pol2qm74 6059 15 - - HYPH cord-015021-pol2qm74 6059 16 II II NNP cord-015021-pol2qm74 6059 17 score score NN cord-015021-pol2qm74 6059 18 . . . cord-015021-pol2qm74 6060 1 There there EX cord-015021-pol2qm74 6060 2 is be VBZ cord-015021-pol2qm74 6060 3 significant significant JJ cord-015021-pol2qm74 6060 4 difference difference NN cord-015021-pol2qm74 6060 5 between between IN cord-015021-pol2qm74 6060 6 the the DT cord-015021-pol2qm74 6060 7 ROC ROC NNP cord-015021-pol2qm74 6060 8 - - HYPH cord-015021-pol2qm74 6060 9 curve curve NN cord-015021-pol2qm74 6060 10 of of IN cord-015021-pol2qm74 6060 11 APACHE APACHE NNP cord-015021-pol2qm74 6060 12 - - HYPH cord-015021-pol2qm74 6060 13 II II NNP cord-015021-pol2qm74 6060 14 scare scare NN cord-015021-pol2qm74 6060 15 . . . cord-015021-pol2qm74 6061 1 The the DT cord-015021-pol2qm74 6061 2 k. k. NNP cord-015021-pol2qm74 6062 1 P.Tit P.Tit NNP cord-015021-pol2qm74 6063 1 ~v ~v NNP cord-015021-pol2qm74 6063 2 . . . cord-015021-pol2qm74 6063 3 ,I.E.Gurmanchuk ,I.E.Gurmanchuk NFP cord-015021-pol2qm74 6063 4 . . . cord-015021-pol2qm74 6064 1 Objectives objective NNS cord-015021-pol2qm74 6064 2 of of IN cord-015021-pol2qm74 6064 3 the the DT cord-015021-pol2qm74 6064 4 study study NN cord-015021-pol2qm74 6064 5 . . . cord-015021-pol2qm74 6065 1 Sepsis sepsis NN cord-015021-pol2qm74 6065 2 is be VBZ cord-015021-pol2qm74 6065 3 a a DT cord-015021-pol2qm74 6065 4 severe severe JJ cord-015021-pol2qm74 6065 5 complication complication NN cord-015021-pol2qm74 6065 6 of of IN cord-015021-pol2qm74 6065 7 the the DT cord-015021-pol2qm74 6065 8 local local JJ cord-015021-pol2qm74 6065 9 infection infection NN cord-015021-pol2qm74 6065 10 , , , cord-015021-pol2qm74 6065 11 Th Th NNP cord-015021-pol2qm74 6065 12 e e NN cord-015021-pol2qm74 6065 13 fever fever NN cord-015021-pol2qm74 6065 14 and and CC cord-015021-pol2qm74 6065 15 the the DT cord-015021-pol2qm74 6065 16 systemic systemic JJ cord-015021-pol2qm74 6065 17 inflammatory inflammatory JJ cord-015021-pol2qm74 6065 18 response response NN cord-015021-pol2qm74 6065 19 syndrome syndrome NN cord-015021-pol2qm74 6065 20 may may MD cord-015021-pol2qm74 6065 21 take take VB cord-015021-pol2qm74 6065 22 place place NN cord-015021-pol2qm74 6065 23 in in IN cord-015021-pol2qm74 6065 24 such such PDT cord-015021-pol2qm74 6065 25 a a DT cord-015021-pol2qm74 6065 26 case case NN cord-015021-pol2qm74 6065 27 as as IN cord-015021-pol2qm74 6065 28 manifistations manifistation NNS cord-015021-pol2qm74 6065 29 of of IN cord-015021-pol2qm74 6065 30 the the DT cord-015021-pol2qm74 6065 31 inflammation inflammation NN cord-015021-pol2qm74 6065 32 induced induce VBN cord-015021-pol2qm74 6065 33 by by IN cord-015021-pol2qm74 6065 34 bacteria bacteria NNS cord-015021-pol2qm74 6065 35 . . . cord-015021-pol2qm74 6066 1 The the DT cord-015021-pol2qm74 6066 2 systemic systemic JJ cord-015021-pol2qm74 6066 3 fever fever NN cord-015021-pol2qm74 6066 4 observed observe VBN cord-015021-pol2qm74 6066 5 in in IN cord-015021-pol2qm74 6066 6 infection infection NN cord-015021-pol2qm74 6066 7 is be VBZ cord-015021-pol2qm74 6066 8 known know VBN cord-015021-pol2qm74 6066 9 to to TO cord-015021-pol2qm74 6066 10 develop develop VB cord-015021-pol2qm74 6066 11 due due IN cord-015021-pol2qm74 6066 12 to to IN cord-015021-pol2qm74 6066 13 the the DT cord-015021-pol2qm74 6066 14 action action NN cord-015021-pol2qm74 6066 15 of of IN cord-015021-pol2qm74 6066 16 certain certain JJ cord-015021-pol2qm74 6066 17 cytoldnes cytoldne NNS cord-015021-pol2qm74 6066 18 . . . cord-015021-pol2qm74 6067 1 Other other JJ cord-015021-pol2qm74 6067 2 systemic systemic JJ cord-015021-pol2qm74 6067 3 manffistation manffistation NN cord-015021-pol2qm74 6067 4 of of IN cord-015021-pol2qm74 6067 5 inflammation inflammation NN cord-015021-pol2qm74 6067 6 are be VBP cord-015021-pol2qm74 6067 7 the the DT cord-015021-pol2qm74 6067 8 production production NN cord-015021-pol2qm74 6067 9 of of IN cord-015021-pol2qm74 6067 10 acute acute JJ cord-015021-pol2qm74 6067 11 phase phase NN cord-015021-pol2qm74 6067 12 reactants reactant NNS cord-015021-pol2qm74 6067 13 , , , cord-015021-pol2qm74 6067 14 acute acute JJ cord-015021-pol2qm74 6067 15 phase phase NN cord-015021-pol2qm74 6067 16 proteins protein NNS cord-015021-pol2qm74 6067 17 , , , cord-015021-pol2qm74 6067 18 the the DT cord-015021-pol2qm74 6067 19 activation activation NN cord-015021-pol2qm74 6067 20 of of IN cord-015021-pol2qm74 6067 21 the the DT cord-015021-pol2qm74 6067 22 complement complement NN cord-015021-pol2qm74 6067 23 system system NN cord-015021-pol2qm74 6067 24 . . . cord-015021-pol2qm74 6068 1 IVratertals ivratertal NNS cord-015021-pol2qm74 6068 2 and and CC cord-015021-pol2qm74 6068 3 methods method NNS cord-015021-pol2qm74 6068 4 . . . cord-015021-pol2qm74 6069 1 We -PRON- PRP cord-015021-pol2qm74 6069 2 observed observe VBD cord-015021-pol2qm74 6069 3 35 35 CD cord-015021-pol2qm74 6069 4 children child NNS cord-015021-pol2qm74 6069 5 with with IN cord-015021-pol2qm74 6069 6 light light NN cord-015021-pol2qm74 6069 7 and and CC cord-015021-pol2qm74 6069 8 45 45 CD cord-015021-pol2qm74 6069 9 children child NNS cord-015021-pol2qm74 6069 10 with with IN cord-015021-pol2qm74 6069 11 severe severe JJ cord-015021-pol2qm74 6069 12 course(l-3 course(l-3 NNP cord-015021-pol2qm74 6069 13 class class NN cord-015021-pol2qm74 6069 14 of of IN cord-015021-pol2qm74 6069 15 serionuess serionuess NNP cord-015021-pol2qm74 6069 16 ) ) -RRB- cord-015021-pol2qm74 6069 17 of of IN cord-015021-pol2qm74 6069 18 the the DT cord-015021-pol2qm74 6069 19 sepsis sepsis NN cord-015021-pol2qm74 6069 20 . . . cord-015021-pol2qm74 6070 1 The the DT cord-015021-pol2qm74 6070 2 ftmetional ftmetional JJ cord-015021-pol2qm74 6070 3 activity activity NN cord-015021-pol2qm74 6070 4 of of IN cord-015021-pol2qm74 6070 5 the the DT cord-015021-pol2qm74 6070 6 complement complement NN cord-015021-pol2qm74 6070 7 system system NN cord-015021-pol2qm74 6070 8 ( ( -LRB- cord-015021-pol2qm74 6070 9 CH50 CH50 NNP cord-015021-pol2qm74 6070 10 , , , cord-015021-pol2qm74 6070 11 level level NN cord-015021-pol2qm74 6070 12 of of IN cord-015021-pol2qm74 6070 13 C C NNP cord-015021-pol2qm74 6070 14 1-C5 1-c5 CD cord-015021-pol2qm74 6070 15 , , , cord-015021-pol2qm74 6070 16 factors factor NNS cord-015021-pol2qm74 6070 17 B B NNP cord-015021-pol2qm74 6070 18 told tell VBD cord-015021-pol2qm74 6070 19 D D NNP cord-015021-pol2qm74 6070 20 , , , cord-015021-pol2qm74 6070 21 C3a C3a NNP cord-015021-pol2qm74 6070 22 ) ) -RRB- cord-015021-pol2qm74 6070 23 , , , cord-015021-pol2qm74 6070 24 level level NN cord-015021-pol2qm74 6070 25 of of IN cord-015021-pol2qm74 6070 26 C c NN cord-015021-pol2qm74 6070 27 - - HYPH cord-015021-pol2qm74 6070 28 reactive reactive JJ cord-015021-pol2qm74 6070 29 protein protein NN cord-015021-pol2qm74 6070 30 ( ( -LRB- cord-015021-pol2qm74 6070 31 CRP CRP NNP cord-015021-pol2qm74 6070 32 } } -RRB- cord-015021-pol2qm74 6070 33 and and CC cord-015021-pol2qm74 6070 34 tumor tumor NN cord-015021-pol2qm74 6070 35 necrosis necrosis NN cord-015021-pol2qm74 6070 36 factor factor NN cord-015021-pol2qm74 6070 37 ( ( -LRB- cord-015021-pol2qm74 6070 38 TNF TNF NNP cord-015021-pol2qm74 6070 39 ) ) -RRB- cord-015021-pol2qm74 6070 40 were be VBD cord-015021-pol2qm74 6070 41 investigated investigate VBN cord-015021-pol2qm74 6070 42 , , , cord-015021-pol2qm74 6070 43 Results result NNS cord-015021-pol2qm74 6070 44 . . . cord-015021-pol2qm74 6071 1 The the DT cord-015021-pol2qm74 6071 2 level level NN cord-015021-pol2qm74 6071 3 of of IN cord-015021-pol2qm74 6071 4 CRP CRP NNP cord-015021-pol2qm74 6071 5 was be VBD cord-015021-pol2qm74 6071 6 increased increase VBN cord-015021-pol2qm74 6071 7 in in IN cord-015021-pol2qm74 6071 8 the the DT cord-015021-pol2qm74 6071 9 children child NNS cord-015021-pol2qm74 6071 10 with with IN cord-015021-pol2qm74 6071 11 more more RBR cord-015021-pol2qm74 6071 12 severe severe JJ cord-015021-pol2qm74 6071 13 class class NN cord-015021-pol2qm74 6071 14 of of IN cord-015021-pol2qm74 6071 15 the the DT cord-015021-pol2qm74 6071 16 septic septic JJ cord-015021-pol2qm74 6071 17 process process NN cord-015021-pol2qm74 6071 18 in in IN cord-015021-pol2qm74 6071 19 both both DT cord-015021-pol2qm74 6071 20 group group NN cord-015021-pol2qm74 6071 21 ( ( -LRB- cord-015021-pol2qm74 6071 22 60%-1 60%-1 CD cord-015021-pol2qm74 6071 23 st st NNP cord-015021-pol2qm74 6071 24 and and CC cord-015021-pol2qm74 6071 25 iOO%-2 iOO%-2 NNP cord-015021-pol2qm74 6071 26 nd nd NNP cord-015021-pol2qm74 6071 27 } } -RRB- cord-015021-pol2qm74 6071 28 ( ( -LRB- cord-015021-pol2qm74 6071 29 with with IN cord-015021-pol2qm74 6071 30 light light JJ cord-015021-pol2qm74 6071 31 and and CC cord-015021-pol2qm74 6071 32 hard hard JJ cord-015021-pol2qm74 6071 33 eours eour NNS cord-015021-pol2qm74 6071 34 of of IN cord-015021-pol2qm74 6071 35 disese disese NNP cord-015021-pol2qm74 6071 36 ) ) -RRB- cord-015021-pol2qm74 6071 37 of of IN cord-015021-pol2qm74 6071 38 patients patient NNS cord-015021-pol2qm74 6071 39 . . . cord-015021-pol2qm74 6072 1 Parameters parameter NNS cord-015021-pol2qm74 6072 2 of of IN cord-015021-pol2qm74 6072 3 the the DT cord-015021-pol2qm74 6072 4 complement complement NN cord-015021-pol2qm74 6072 5 system system NN cord-015021-pol2qm74 6072 6 -the -the WDT cord-015021-pol2qm74 6072 7 activity activity NN cord-015021-pol2qm74 6072 8 of of IN cord-015021-pol2qm74 6072 9 Cl Cl NNP cord-015021-pol2qm74 6072 10 , , , cord-015021-pol2qm74 6072 11 C4 C4 NNP cord-015021-pol2qm74 6072 12 , , , cord-015021-pol2qm74 6072 13 C3 c3 NN cord-015021-pol2qm74 6072 14 components component NNS cord-015021-pol2qm74 6072 15 , , , cord-015021-pol2qm74 6072 16 activity activity NN cord-015021-pol2qm74 6072 17 of of IN cord-015021-pol2qm74 6072 18 B b NN cord-015021-pol2qm74 6072 19 and and CC cord-015021-pol2qm74 6072 20 D d NN cord-015021-pol2qm74 6072 21 factors factor NNS cord-015021-pol2qm74 6072 22 - - , cord-015021-pol2qm74 6072 23 were be VBD cord-015021-pol2qm74 6072 24 increased increase VBN cord-015021-pol2qm74 6072 25 in in IN cord-015021-pol2qm74 6072 26 the the DT cord-015021-pol2qm74 6072 27 seram seram NNP cord-015021-pol2qm74 6072 28 of of IN cord-015021-pol2qm74 6072 29 children child NNS cord-015021-pol2qm74 6072 30 with with IN cord-015021-pol2qm74 6072 31 light light JJ cord-015021-pol2qm74 6072 32 course course NN cord-015021-pol2qm74 6072 33 of of IN cord-015021-pol2qm74 6072 34 sepsis sepsis NN cord-015021-pol2qm74 6072 35 . . . cord-015021-pol2qm74 6073 1 In in IN cord-015021-pol2qm74 6073 2 children child NNS cord-015021-pol2qm74 6073 3 with with IN cord-015021-pol2qm74 6073 4 severe severe JJ cord-015021-pol2qm74 6073 5 course course NN cord-015021-pol2qm74 6073 6 of of IN cord-015021-pol2qm74 6073 7 sepsis sepsis NN cord-015021-pol2qm74 6073 8 these these DT cord-015021-pol2qm74 6073 9 parameters parameter NNS cord-015021-pol2qm74 6073 10 were be VBD cord-015021-pol2qm74 6073 11 signffieantty signffieantty JJ cord-015021-pol2qm74 6073 12 decreased decrease VBD cord-015021-pol2qm74 6073 13 , , , cord-015021-pol2qm74 6073 14 especially especially RB cord-015021-pol2qm74 6073 15 in in IN cord-015021-pol2qm74 6073 16 the the DT cord-015021-pol2qm74 6073 17 group group NN cord-015021-pol2qm74 6073 18 of of IN cord-015021-pol2qm74 6073 19 chiidrellwith chiidrellwith NNP cord-015021-pol2qm74 6073 20 higer hig JJR cord-015021-pol2qm74 6073 21 level level NN cord-015021-pol2qm74 6073 22 of of IN cord-015021-pol2qm74 6073 23 CRP crp NN cord-015021-pol2qm74 6073 24 . . . cord-015021-pol2qm74 6074 1 We -PRON- PRP cord-015021-pol2qm74 6074 2 found find VBD cord-015021-pol2qm74 6074 3 the the DT cord-015021-pol2qm74 6074 4 negative negative JJ cord-015021-pol2qm74 6074 5 correlation correlation NN cord-015021-pol2qm74 6074 6 of of IN cord-015021-pol2qm74 6074 7 the the DT cord-015021-pol2qm74 6074 8 TNP TNP NNP cord-015021-pol2qm74 6074 9 - - HYPH cord-015021-pol2qm74 6074 10 alfa alfa NNP cord-015021-pol2qm74 6074 11 concentration concentration NN cord-015021-pol2qm74 6074 12 with with IN cord-015021-pol2qm74 6074 13 the the DT cord-015021-pol2qm74 6074 14 functional functional JJ cord-015021-pol2qm74 6074 15 activity activity NN cord-015021-pol2qm74 6074 16 of of IN cord-015021-pol2qm74 6074 17 classical classical JJ cord-015021-pol2qm74 6074 18 pathway pathway NN cord-015021-pol2qm74 6074 19 components component NNS cord-015021-pol2qm74 6074 20 ( ( -LRB- cord-015021-pol2qm74 6074 21 Cl~3 Cl~3 NNP cord-015021-pol2qm74 6074 22 ) ) -RRB- cord-015021-pol2qm74 6074 23 and and CC cord-015021-pol2qm74 6074 24 the the DT cord-015021-pol2qm74 6074 25 positive positive JJ cord-015021-pol2qm74 6074 26 onewith onewith NN cord-015021-pol2qm74 6074 27 the the DT cord-015021-pol2qm74 6074 28 funfional funfional JJ cord-015021-pol2qm74 6074 29 activity activity NN cord-015021-pol2qm74 6074 30 of of IN cord-015021-pol2qm74 6074 31 the the DT cord-015021-pol2qm74 6074 32 alternative alternative JJ cord-015021-pol2qm74 6074 33 pathway pathway NN cord-015021-pol2qm74 6074 34 factors factor NNS cord-015021-pol2qm74 6074 35 B b NN cord-015021-pol2qm74 6074 36 - - : cord-015021-pol2qm74 6074 37 and and CC cord-015021-pol2qm74 6074 38 D d NN cord-015021-pol2qm74 6074 39 of of IN cord-015021-pol2qm74 6074 40 the the DT cord-015021-pol2qm74 6074 41 complement complement NN cord-015021-pol2qm74 6074 42 system system NN cord-015021-pol2qm74 6074 43 . . . cord-015021-pol2qm74 6075 1 Conclusions conclusion NNS cord-015021-pol2qm74 6075 2 . . . cord-015021-pol2qm74 6076 1 Thus thus RB cord-015021-pol2qm74 6076 2 , , , cord-015021-pol2qm74 6076 3 in in IN cord-015021-pol2qm74 6076 4 children child NNS cord-015021-pol2qm74 6076 5 with with IN cord-015021-pol2qm74 6076 6 different different JJ cord-015021-pol2qm74 6076 7 course course NN cord-015021-pol2qm74 6076 8 of of IN cord-015021-pol2qm74 6076 9 sepsis sepsis NN cord-015021-pol2qm74 6076 10 certain certain JJ cord-015021-pol2qm74 6076 11 changes change NNS cord-015021-pol2qm74 6076 12 in in IN cord-015021-pol2qm74 6076 13 levels level NNS cord-015021-pol2qm74 6076 14 and and CC cord-015021-pol2qm74 6076 15 functional functional JJ cord-015021-pol2qm74 6076 16 activity activity NN cord-015021-pol2qm74 6076 17 of of IN cord-015021-pol2qm74 6076 18 an an DT cord-015021-pol2qm74 6076 19 acute acute JJ cord-015021-pol2qm74 6076 20 phase phase NN cord-015021-pol2qm74 6076 21 o o NN cord-015021-pol2qm74 6076 22 [ [ -LRB- cord-015021-pol2qm74 6076 23 inflammation inflammation NN cord-015021-pol2qm74 6076 24 proteins protein NNS cord-015021-pol2qm74 6076 25 -CRP -CRP : cord-015021-pol2qm74 6076 26 and and CC cord-015021-pol2qm74 6076 27 the the DT cord-015021-pol2qm74 6076 28 complement complement NN cord-015021-pol2qm74 6076 29 system system NN cord-015021-pol2qm74 6076 30 ones one NNS cord-015021-pol2qm74 6076 31 -&Ire -&Ire . cord-015021-pol2qm74 6077 1 characteristic characteristic JJ cord-015021-pol2qm74 6077 2 . . . cord-015021-pol2qm74 6078 1 The the DT cord-015021-pol2qm74 6078 2 relationship relationship NN cord-015021-pol2qm74 6078 3 between between IN cord-015021-pol2qm74 6078 4 the the DT cord-015021-pol2qm74 6078 5 TNF TNF NNP cord-015021-pol2qm74 6078 6 - - HYPH cord-015021-pol2qm74 6078 7 alfa alfa NNP cord-015021-pol2qm74 6078 8 level level NN cord-015021-pol2qm74 6078 9 and and CC cord-015021-pol2qm74 6078 10 the the DT cord-015021-pol2qm74 6078 11 activity activity NN cord-015021-pol2qm74 6078 12 of of IN cord-015021-pol2qm74 6078 13 classical classical JJ cord-015021-pol2qm74 6078 14 and and CC cord-015021-pol2qm74 6078 15 alternative alternative JJ cord-015021-pol2qm74 6078 16 pathways pathway NNS cord-015021-pol2qm74 6078 17 proteins protein NNS cord-015021-pol2qm74 6078 18 indicates indicate VBZ cord-015021-pol2qm74 6078 19 on on IN cord-015021-pol2qm74 6078 20 its -PRON- PRP$ cord-015021-pol2qm74 6078 21 role role NN cord-015021-pol2qm74 6078 22 in in IN cord-015021-pol2qm74 6078 23 the the DT cord-015021-pol2qm74 6078 24 complement complement NN cord-015021-pol2qm74 6078 25 proteins protein NNS cord-015021-pol2qm74 6078 26 genes gene NNS cord-015021-pol2qm74 6078 27 expression expression NN cord-015021-pol2qm74 6078 28 . . . cord-015021-pol2qm74 6078 29 _SP cord-015021-pol2qm74 6079 1 Schr6der Schr6der NNP cord-015021-pol2qm74 6079 2 J J NNP cord-015021-pol2qm74 6079 3 , , , cord-015021-pol2qm74 6079 4 Braun Braun NNP cord-015021-pol2qm74 6079 5 J J NNP cord-015021-pol2qm74 6079 6 , , , cord-015021-pol2qm74 6079 7 Rennekampff Rennekampff NNP cord-015021-pol2qm74 6079 8 Ha Ha NNP cord-015021-pol2qm74 6079 9 , , , cord-015021-pol2qm74 6079 10 Schr6der schr6der NN cord-015021-pol2qm74 6079 11 DW DW NNP cord-015021-pol2qm74 6079 12 Various various JJ cord-015021-pol2qm74 6079 13 alterations alteration NNS cord-015021-pol2qm74 6079 14 of of IN cord-015021-pol2qm74 6079 15 the the DT cord-015021-pol2qm74 6079 16 immune immune JJ cord-015021-pol2qm74 6079 17 response response NN cord-015021-pol2qm74 6079 18 are be VBP cord-015021-pol2qm74 6079 19 known know VBN cord-015021-pol2qm74 6079 20 in in IN cord-015021-pol2qm74 6079 21 trauma trauma NN cord-015021-pol2qm74 6079 22 , , , cord-015021-pol2qm74 6079 23 but but CC cord-015021-pol2qm74 6079 24 the the DT cord-015021-pol2qm74 6079 25 course course NN cord-015021-pol2qm74 6079 26 will will MD cord-015021-pol2qm74 6079 27 not not RB cord-015021-pol2qm74 6079 28 be be VB cord-015021-pol2qm74 6079 29 complicated complicate VBN cord-015021-pol2qm74 6079 30 by by IN cord-015021-pol2qm74 6079 31 multiple multiple JJ cord-015021-pol2qm74 6079 32 organ organ NN cord-015021-pol2qm74 6079 33 dysfunction dysfunction NN cord-015021-pol2qm74 6079 34 syndrome syndrome NN cord-015021-pol2qm74 6079 35 ( ( -LRB- cord-015021-pol2qm74 6079 36 MODS MODS NNP cord-015021-pol2qm74 6079 37 ) ) -RRB- cord-015021-pol2qm74 6079 38 in in IN cord-015021-pol2qm74 6079 39 all all DT cord-015021-pol2qm74 6079 40 patients patient NNS cord-015021-pol2qm74 6079 41 . . . cord-015021-pol2qm74 6080 1 Phenotyping phenotyping NN cord-015021-pol2qm74 6080 2 of of IN cord-015021-pol2qm74 6080 3 cells cell NNS cord-015021-pol2qm74 6080 4 offers offer VBZ cord-015021-pol2qm74 6080 5 a a DT cord-015021-pol2qm74 6080 6 rapid rapid JJ cord-015021-pol2qm74 6080 7 system system NN cord-015021-pol2qm74 6080 8 of of IN cord-015021-pol2qm74 6080 9 evaluation evaluation NN cord-015021-pol2qm74 6080 10 certain certain JJ cord-015021-pol2qm74 6080 11 aspects aspect NNS cord-015021-pol2qm74 6080 12 of of IN cord-015021-pol2qm74 6080 13 the the DT cord-015021-pol2qm74 6080 14 immune immune JJ cord-015021-pol2qm74 6080 15 response response NN cord-015021-pol2qm74 6080 16 . . . cord-015021-pol2qm74 6081 1 Different different JJ cord-015021-pol2qm74 6081 2 subsets subset NNS cord-015021-pol2qm74 6081 3 of of IN cord-015021-pol2qm74 6081 4 lymphocytes lymphocyte NNS cord-015021-pol2qm74 6081 5 and and CC cord-015021-pol2qm74 6081 6 neutrophils neutrophil NNS cord-015021-pol2qm74 6081 7 were be VBD cord-015021-pol2qm74 6081 8 determined determine VBN cord-015021-pol2qm74 6081 9 to to TO cord-015021-pol2qm74 6081 10 evaluate evaluate VB cord-015021-pol2qm74 6081 11 their -PRON- PRP$ cord-015021-pol2qm74 6081 12 prognostic prognostic JJ cord-015021-pol2qm74 6081 13 role role NN cord-015021-pol2qm74 6081 14 in in IN cord-015021-pol2qm74 6081 15 developement developement NN cord-015021-pol2qm74 6081 16 of of IN cord-015021-pol2qm74 6081 17 MODS MODS NNP cord-015021-pol2qm74 6081 18 . . . cord-015021-pol2qm74 6082 1 In in IN cord-015021-pol2qm74 6082 2 16 16 CD cord-015021-pol2qm74 6082 3 trauma trauma NN cord-015021-pol2qm74 6082 4 patients patient NNS cord-015021-pol2qm74 6082 5 with with IN cord-015021-pol2qm74 6082 6 an an DT cord-015021-pol2qm74 6082 7 injury injury NN cord-015021-pol2qm74 6082 8 severity severity NN cord-015021-pol2qm74 6082 9 score score NN cord-015021-pol2qm74 6082 10 ( ( -LRB- cord-015021-pol2qm74 6082 11 ISS ISS NNP cord-015021-pol2qm74 6082 12 ) ) -RRB- cord-015021-pol2qm74 6082 13 > > NFP cord-015021-pol2qm74 6082 14 20 20 CD cord-015021-pol2qm74 6082 15 ( ( -LRB- cord-015021-pol2qm74 6082 16 mean mean VB cord-015021-pol2qm74 6082 17 ISS ISS NNP cord-015021-pol2qm74 6082 18 = = SYM cord-015021-pol2qm74 6082 19 32 32 CD cord-015021-pol2qm74 6082 20 ; ; : cord-015021-pol2qm74 6082 21 mean mean VB cord-015021-pol2qm74 6082 22 age age NN cord-015021-pol2qm74 6082 23 41 41 CD cord-015021-pol2qm74 6082 24 years year NNS cord-015021-pol2qm74 6082 25 ) ) -RRB- cord-015021-pol2qm74 6082 26 lymphocyte lymphocyte NN cord-015021-pol2qm74 6082 27 and and CC cord-015021-pol2qm74 6082 28 neutrophil neutrophil NN cord-015021-pol2qm74 6082 29 phenotypes phenotype NNS cord-015021-pol2qm74 6082 30 CD cd NN cord-015021-pol2qm74 6082 31 3 3 CD cord-015021-pol2qm74 6083 1 ( ( -LRB- cord-015021-pol2qm74 6083 2 T t NN cord-015021-pol2qm74 6083 3 - - HYPH cord-015021-pol2qm74 6083 4 cells cell NNS cord-015021-pol2qm74 6083 5 ) ) -RRB- cord-015021-pol2qm74 6083 6 , , , cord-015021-pol2qm74 6083 7 CD CD NNP cord-015021-pol2qm74 6083 8 4 4 CD cord-015021-pol2qm74 6084 1 ( ( -LRB- cord-015021-pol2qm74 6084 2 T t NN cord-015021-pol2qm74 6084 3 - - HYPH cord-015021-pol2qm74 6084 4 helper helper NN cord-015021-pol2qm74 6084 5 cells cell NNS cord-015021-pol2qm74 6084 6 ) ) -RRB- cord-015021-pol2qm74 6084 7 , , , cord-015021-pol2qm74 6084 8 CD CD NNP cord-015021-pol2qm74 6084 9 8 8 CD cord-015021-pol2qm74 6084 10 ( ( -LRB- cord-015021-pol2qm74 6084 11 T t NN cord-015021-pol2qm74 6084 12 - - HYPH cord-015021-pol2qm74 6084 13 suppressor suppressor NN cord-015021-pol2qm74 6084 14 cells cell NNS cord-015021-pol2qm74 6084 15 ) ) -RRB- cord-015021-pol2qm74 6085 1 , , , cord-015021-pol2qm74 6085 2 ratio ratio NN cord-015021-pol2qm74 6085 3 CD CD NNP cord-015021-pol2qm74 6085 4 4 4 CD cord-015021-pol2qm74 6085 5 / / SYM cord-015021-pol2qm74 6085 6 CD CD NNP cord-015021-pol2qm74 6085 7 8 8 CD cord-015021-pol2qm74 6085 8 , , , cord-015021-pol2qm74 6085 9 CD cd NN cord-015021-pol2qm74 6085 10 11b 11b NNS cord-015021-pol2qm74 6086 1 ( ( -LRB- cord-015021-pol2qm74 6086 2 receptor receptor NN cord-015021-pol2qm74 6086 3 for for IN cord-015021-pol2qm74 6086 4 CR CR NNP cord-015021-pol2qm74 6086 5 3 3 CD cord-015021-pol2qm74 6086 6 ) ) -RRB- cord-015021-pol2qm74 6086 7 and and CC cord-015021-pol2qm74 6086 8 CD CD NNP cord-015021-pol2qm74 6086 9 16 16 CD cord-015021-pol2qm74 6087 1 ( ( -LRB- cord-015021-pol2qm74 6087 2 FcRIII FcRIII NNP cord-015021-pol2qm74 6087 3 ) ) -RRB- cord-015021-pol2qm74 6087 4 were be VBD cord-015021-pol2qm74 6087 5 measured measure VBN cord-015021-pol2qm74 6087 6 on on IN cord-015021-pol2qm74 6087 7 day day NN cord-015021-pol2qm74 6087 8 1,2,3,5,7 1,2,3,5,7 CD cord-015021-pol2qm74 6087 9 and and CC cord-015021-pol2qm74 6087 10 10 10 CD cord-015021-pol2qm74 6087 11 post post NN cord-015021-pol2qm74 6087 12 trauma trauma NN cord-015021-pol2qm74 6087 13 . . . cord-015021-pol2qm74 6088 1 The the DT cord-015021-pol2qm74 6088 2 expression expression NN cord-015021-pol2qm74 6088 3 of of IN cord-015021-pol2qm74 6088 4 class class NN cord-015021-pol2qm74 6088 5 II II NNP cord-015021-pol2qm74 6088 6 histocompatibility histocompatibility NN cord-015021-pol2qm74 6088 7 antigen antigen NN cord-015021-pol2qm74 6088 8 ( ( -LRB- cord-015021-pol2qm74 6088 9 HLADR HLADR NNP cord-015021-pol2qm74 6088 10 ) ) -RRB- cord-015021-pol2qm74 6088 11 on on IN cord-015021-pol2qm74 6088 12 monocytes monocyte NNS cord-015021-pol2qm74 6088 13 ( ( -LRB- cord-015021-pol2qm74 6088 14 HLADR+ hladr+ DT cord-015021-pol2qm74 6088 15 CD CD NNP cord-015021-pol2qm74 6088 16 14 14 CD cord-015021-pol2qm74 6088 17 ) ) -RRB- cord-015021-pol2qm74 6088 18 and and CC cord-015021-pol2qm74 6088 19 IL IL NNP cord-015021-pol2qm74 6088 20 2-receptors 2-receptors CD cord-015021-pol2qm74 6088 21 on on IN cord-015021-pol2qm74 6088 22 T t NN cord-015021-pol2qm74 6088 23 - - HYPH cord-015021-pol2qm74 6088 24 helper helper NN cord-015021-pol2qm74 6088 25 cells cell NNS cord-015021-pol2qm74 6088 26 ( ( -LRB- cord-015021-pol2qm74 6088 27 CD CD NNP cord-015021-pol2qm74 6088 28 25 25 CD cord-015021-pol2qm74 6089 1 /CD /cd CD cord-015021-pol2qm74 6089 2 41 41 CD cord-015021-pol2qm74 6089 3 were be VBD cord-015021-pol2qm74 6089 4 determined determine VBN cord-015021-pol2qm74 6089 5 as as RB cord-015021-pol2qm74 6089 6 well well RB cord-015021-pol2qm74 6089 7 . . . cord-015021-pol2qm74 6090 1 The the DT cord-015021-pol2qm74 6090 2 percentage percentage NN cord-015021-pol2qm74 6090 3 of of IN cord-015021-pol2qm74 6090 4 cells cell NNS cord-015021-pol2qm74 6090 5 was be VBD cord-015021-pol2qm74 6090 6 monitored monitor VBN cord-015021-pol2qm74 6090 7 by by IN cord-015021-pol2qm74 6090 8 immunofluorescence immunofluorescence NN cord-015021-pol2qm74 6090 9 using use VBG cord-015021-pol2qm74 6090 10 monoclonal monoclonal JJ cord-015021-pol2qm74 6090 11 antibodies antibody NNS cord-015021-pol2qm74 6090 12 and and CC cord-015021-pol2qm74 6090 13 three three CD cord-015021-pol2qm74 6090 14 color color NN cord-015021-pol2qm74 6090 15 cytometry cytometry NN cord-015021-pol2qm74 6090 16 . . . cord-015021-pol2qm74 6091 1 The the DT cord-015021-pol2qm74 6091 2 percentage percentage NN cord-015021-pol2qm74 6091 3 of of IN cord-015021-pol2qm74 6091 4 HLADR+ HLADR+ NNP cord-015021-pol2qm74 6091 5 CD CD NNP cord-015021-pol2qm74 6091 6 14 14 CD cord-015021-pol2qm74 6091 7 were be VBD cord-015021-pol2qm74 6091 8 significantly significantly RB cord-015021-pol2qm74 6091 9 lower low JJR cord-015021-pol2qm74 6091 10 an an DT cord-015021-pol2qm74 6091 11 day day NN cord-015021-pol2qm74 6091 12 2,5,7 2,5,7 CD cord-015021-pol2qm74 6091 13 and and CC cord-015021-pol2qm74 6091 14 10 10 CD cord-015021-pol2qm74 6091 15 in in IN cord-015021-pol2qm74 6091 16 patients patient NNS cord-015021-pol2qm74 6091 17 who who WP cord-015021-pol2qm74 6091 18 developed develop VBD cord-015021-pol2qm74 6091 19 MODS mod NNS cord-015021-pol2qm74 6091 20 ( ( -LRB- cord-015021-pol2qm74 6091 21 p<0,05 p<0,05 NNP cord-015021-pol2qm74 6091 22 ) ) -RRB- cord-015021-pol2qm74 6091 23 compared compare VBN cord-015021-pol2qm74 6091 24 to to IN cord-015021-pol2qm74 6091 25 patients patient NNS cord-015021-pol2qm74 6091 26 without without IN cord-015021-pol2qm74 6091 27 MODS mods NN cord-015021-pol2qm74 6091 28 and and CC cord-015021-pol2qm74 6091 29 a a DT cord-015021-pol2qm74 6091 30 healthy healthy JJ cord-015021-pol2qm74 6091 31 control control NN cord-015021-pol2qm74 6092 1 ( ( -LRB- cord-015021-pol2qm74 6092 2 p p NN cord-015021-pol2qm74 6092 3 < < XX cord-015021-pol2qm74 6092 4 O o UH cord-015021-pol2qm74 6092 5 , , , cord-015021-pol2qm74 6092 6 O01 O01 NNP cord-015021-pol2qm74 6092 7 ) ) -RRB- cord-015021-pol2qm74 6092 8 . . . cord-015021-pol2qm74 6093 1 The the DT cord-015021-pol2qm74 6093 2 expression expression NN cord-015021-pol2qm74 6093 3 of of IN cord-015021-pol2qm74 6093 4 IL IL NNP cord-015021-pol2qm74 6093 5 2receptors 2receptors CD cord-015021-pol2qm74 6093 6 on on IN cord-015021-pol2qm74 6093 7 CD CD NNP cord-015021-pol2qm74 6093 8 4 4 CD cord-015021-pol2qm74 6093 9 was be VBD cord-015021-pol2qm74 6093 10 significantly significantly RB cord-015021-pol2qm74 6093 11 different different JJ cord-015021-pol2qm74 6093 12 only only RB cord-015021-pol2qm74 6093 13 on on IN cord-015021-pol2qm74 6093 14 day day NN cord-015021-pol2qm74 6093 15 2 2 CD cord-015021-pol2qm74 6093 16 . . . cord-015021-pol2qm74 6094 1 No no DT cord-015021-pol2qm74 6094 2 differences difference NNS cord-015021-pol2qm74 6094 3 could could MD cord-015021-pol2qm74 6094 4 be be VB cord-015021-pol2qm74 6094 5 measured measure VBN cord-015021-pol2qm74 6094 6 in in IN cord-015021-pol2qm74 6094 7 lymphocyte lymphocyte NN cord-015021-pol2qm74 6094 8 phenotypes phenotype NNS cord-015021-pol2qm74 6094 9 CD CD NNP cord-015021-pol2qm74 6094 10 3 3 CD cord-015021-pol2qm74 6094 11 , , , cord-015021-pol2qm74 6094 12 4 4 CD cord-015021-pol2qm74 6094 13 , , , cord-015021-pol2qm74 6094 14 8 8 CD cord-015021-pol2qm74 6094 15 and and CC cord-015021-pol2qm74 6094 16 CD CD NNP cord-015021-pol2qm74 6094 17 4 4 CD cord-015021-pol2qm74 6094 18 / / SYM cord-015021-pol2qm74 6094 19 CD CD NNP cord-015021-pol2qm74 6094 20 8-ratio 8-ratio CD cord-015021-pol2qm74 6095 1 as as RB cord-015021-pol2qm74 6095 2 well well RB cord-015021-pol2qm74 6095 3 as as IN cord-015021-pol2qm74 6095 4 in in IN cord-015021-pol2qm74 6095 5 expression expression NN cord-015021-pol2qm74 6095 6 of of IN cord-015021-pol2qm74 6095 7 CD CD NNP cord-015021-pol2qm74 6095 8 11b 11b NNS cord-015021-pol2qm74 6095 9 and and CC cord-015021-pol2qm74 6095 10 CD CD NNP cord-015021-pol2qm74 6095 11 16 16 CD cord-015021-pol2qm74 6095 12 on on IN cord-015021-pol2qm74 6095 13 neutrophils neutrophil NNS cord-015021-pol2qm74 6095 14 . . . cord-015021-pol2qm74 6096 1 Class Class NNP cord-015021-pol2qm74 6096 2 II II NNP cord-015021-pol2qm74 6096 3 histocompatibility histocompatibility NN cord-015021-pol2qm74 6096 4 antigen antigen NN cord-015021-pol2qm74 6096 5 ( ( -LRB- cord-015021-pol2qm74 6096 6 HLADR HLADR NNP cord-015021-pol2qm74 6096 7 ) ) -RRB- cord-015021-pol2qm74 6096 8 on on IN cord-015021-pol2qm74 6096 9 monocytes monocyte NNS cord-015021-pol2qm74 6096 10 offers offer VBZ cord-015021-pol2qm74 6096 11 the the DT cord-015021-pol2qm74 6096 12 best good JJS cord-015021-pol2qm74 6096 13 ability ability NN cord-015021-pol2qm74 6096 14 to to TO cord-015021-pol2qm74 6096 15 reflect reflect VB cord-015021-pol2qm74 6096 16 cellular cellular JJ cord-015021-pol2qm74 6096 17 immunosuppression immunosuppression NN cord-015021-pol2qm74 6096 18 in in IN cord-015021-pol2qm74 6096 19 trauma trauma NN cord-015021-pol2qm74 6096 20 . . . cord-015021-pol2qm74 6097 1 This this DT cord-015021-pol2qm74 6097 2 parameter parameter NN cord-015021-pol2qm74 6097 3 allows allow VBZ cord-015021-pol2qm74 6097 4 the the DT cord-015021-pol2qm74 6097 5 best good JJS cord-015021-pol2qm74 6097 6 differentiation differentiation NN cord-015021-pol2qm74 6097 7 of of IN cord-015021-pol2qm74 6097 8 patients patient NNS cord-015021-pol2qm74 6097 9 with with IN cord-015021-pol2qm74 6097 10 and and CC cord-015021-pol2qm74 6097 11 without without IN cord-015021-pol2qm74 6097 12 MODS mod NNS cord-015021-pol2qm74 6097 13 . . . cord-015021-pol2qm74 6098 1 We -PRON- PRP cord-015021-pol2qm74 6098 2 retrospectively retrospectively RB cord-015021-pol2qm74 6098 3 studied study VBD cord-015021-pol2qm74 6098 4 the the DT cord-015021-pol2qm74 6098 5 relative relative JJ cord-015021-pol2qm74 6098 6 importance importance NN cord-015021-pol2qm74 6098 7 of of IN cord-015021-pol2qm74 6098 8 age age NN cord-015021-pol2qm74 6098 9 , , , cord-015021-pol2qm74 6098 10 prior prior JJ cord-015021-pol2qm74 6098 11 chronic chronic JJ cord-015021-pol2qm74 6098 12 disease disease NN cord-015021-pol2qm74 6098 13 , , , cord-015021-pol2qm74 6098 14 sepsis sepsis NN cord-015021-pol2qm74 6098 15 and and CC cord-015021-pol2qm74 6098 16 organ organ NN cord-015021-pol2qm74 6098 17 system system NN cord-015021-pol2qm74 6098 18 failure failure NN cord-015021-pol2qm74 6098 19 ( ( -LRB- cord-015021-pol2qm74 6098 20 OSF OSF NNP cord-015021-pol2qm74 6098 21 ) ) -RRB- cord-015021-pol2qm74 6098 22 to to TO cord-015021-pol2qm74 6098 23 determine determine VB cord-015021-pol2qm74 6098 24 outcome outcome NN cord-015021-pol2qm74 6098 25 in in IN cord-015021-pol2qm74 6098 26 critically critically RB cord-015021-pol2qm74 6098 27 ill ill JJ cord-015021-pol2qm74 6098 28 patients patient NNS cord-015021-pol2qm74 6098 29 with with IN cord-015021-pol2qm74 6098 30 acute acute JJ cord-015021-pol2qm74 6098 31 renal renal JJ cord-015021-pol2qm74 6098 32 failure failure NN cord-015021-pol2qm74 6098 33 ( ( -LRB- cord-015021-pol2qm74 6098 34 ARF ARF NNP cord-015021-pol2qm74 6098 35 ) ) -RRB- cord-015021-pol2qm74 6098 36 . . . cord-015021-pol2qm74 6099 1 ARF ARF NNP cord-015021-pol2qm74 6099 2 was be VBD cord-015021-pol2qm74 6099 3 defined define VBN cord-015021-pol2qm74 6099 4 as as IN cord-015021-pol2qm74 6099 5 serum serum NN cord-015021-pol2qm74 6099 6 creatinine creatinine NN cord-015021-pol2qm74 6099 7 > > XX cord-015021-pol2qm74 6099 8 280 280 CD cord-015021-pol2qm74 6099 9 / / SYM cord-015021-pol2qm74 6099 10 zmol/ zmol/ XX cord-015021-pol2qm74 6100 1 I -PRON- PRP cord-015021-pol2qm74 6100 2 , , , cord-015021-pol2qm74 6100 3 a a DT cord-015021-pol2qm74 6100 4 twofold twofold JJ cord-015021-pol2qm74 6100 5 creatinine creatinine NN cord-015021-pol2qm74 6100 6 rise rise NN cord-015021-pol2qm74 6100 7 in in IN cord-015021-pol2qm74 6100 8 prior prior JJ cord-015021-pol2qm74 6100 9 renal renal JJ cord-015021-pol2qm74 6100 10 insufficiency insufficiency NN cord-015021-pol2qm74 6100 11 or or CC cord-015021-pol2qm74 6100 12 the the DT cord-015021-pol2qm74 6100 13 need need NN cord-015021-pol2qm74 6100 14 of of IN cord-015021-pol2qm74 6100 15 acute acute JJ cord-015021-pol2qm74 6100 16 renal renal JJ cord-015021-pol2qm74 6100 17 replacement replacement NN cord-015021-pol2qm74 6100 18 therapy therapy NN cord-015021-pol2qm74 6100 19 . . . cord-015021-pol2qm74 6101 1 Definitions definition NNS cord-015021-pol2qm74 6101 2 for for IN cord-015021-pol2qm74 6101 3 prior prior JJ cord-015021-pol2qm74 6101 4 chronic chronic JJ cord-015021-pol2qm74 6101 5 disease disease NN cord-015021-pol2qm74 6101 6 and and CC cord-015021-pol2qm74 6101 7 other other JJ cord-015021-pol2qm74 6101 8 OSFs osf NNS cord-015021-pol2qm74 6101 9 -i.e -i.e ADD cord-015021-pol2qm74 6101 10 . . . cord-015021-pol2qm74 6102 1 cardiovascular cardiovascular JJ cord-015021-pol2qm74 6102 2 ( ( -LRB- cord-015021-pol2qm74 6102 3 CF CF NNP cord-015021-pol2qm74 6102 4 ) ) -RRB- cord-015021-pol2qm74 6102 5 , , , cord-015021-pol2qm74 6102 6 pulmonary pulmonary JJ cord-015021-pol2qm74 6102 7 ( ( -LRB- cord-015021-pol2qm74 6102 8 PF PF NNP cord-015021-pol2qm74 6102 9 ) ) -RRB- cord-015021-pol2qm74 6102 10 , , , cord-015021-pol2qm74 6102 11 neurological neurological JJ cord-015021-pol2qm74 6102 12 ( ( -LRB- cord-015021-pol2qm74 6102 13 NF NF NNP cord-015021-pol2qm74 6102 14 ) ) -RRB- cord-015021-pol2qm74 6102 15 , , , cord-015021-pol2qm74 6102 16 haematological haematological FW cord-015021-pol2qm74 6102 17 ( ( -LRB- cord-015021-pol2qm74 6102 18 HF HF NNP cord-015021-pol2qm74 6102 19 ) ) -RRB- cord-015021-pol2qm74 6102 20 , , , cord-015021-pol2qm74 6102 21 hepatic hepatic JJ cord-015021-pol2qm74 6102 22 ( ( -LRB- cord-015021-pol2qm74 6102 23 LF LF NNP cord-015021-pol2qm74 6102 24 ) ) -RRB- cord-015021-pol2qm74 6102 25 , , , cord-015021-pol2qm74 6102 26 and and CC cord-015021-pol2qm74 6102 27 gastrointestinal gastrointestinal JJ cord-015021-pol2qm74 6102 28 failure failure NN cord-015021-pol2qm74 6102 29 ( ( -LRB- cord-015021-pol2qm74 6102 30 GF)-were gf)-were CD cord-015021-pol2qm74 6102 31 derived derive VBN cord-015021-pol2qm74 6102 32 from from IN cord-015021-pol2qm74 6102 33 the the DT cord-015021-pol2qm74 6102 34 literature literature NN cord-015021-pol2qm74 6102 35 and and CC cord-015021-pol2qm74 6102 36 described describe VBD cord-015021-pol2qm74 6102 37 previously previously RB cord-015021-pol2qm74 6102 38 . . . cord-015021-pol2qm74 6103 1 Of of IN cord-015021-pol2qm74 6103 2 the the DT cord-015021-pol2qm74 6103 3 1025 1025 CD cord-015021-pol2qm74 6103 4 consecutively consecutively RB cord-015021-pol2qm74 6103 5 admitted admit VBD cord-015021-pol2qm74 6103 6 patients patient NNS cord-015021-pol2qm74 6103 7 to to IN cord-015021-pol2qm74 6103 8 a a DT cord-015021-pol2qm74 6103 9 surgical surgical JJ cord-015021-pol2qm74 6103 10 and and CC cord-015021-pol2qm74 6103 11 a a DT cord-015021-pol2qm74 6103 12 medical medical JJ cord-015021-pol2qm74 6103 13 intensive intensive JJ cord-015021-pol2qm74 6103 14 care care NN cord-015021-pol2qm74 6103 15 unit unit NN cord-015021-pol2qm74 6103 16 during during IN cord-015021-pol2qm74 6103 17 1 1 CD cord-015021-pol2qm74 6103 18 -ye0r -ye0r NN cord-015021-pol2qm74 6103 19 period period NN cord-015021-pol2qm74 6103 20 , , , cord-015021-pol2qm74 6103 21 136 136 CD cord-015021-pol2qm74 6103 22 ( ( -LRB- cord-015021-pol2qm74 6103 23 13 13 CD cord-015021-pol2qm74 6103 24 % % NN cord-015021-pol2qm74 6103 25 ) ) -RRB- cord-015021-pol2qm74 6103 26 had have VBD cord-015021-pol2qm74 6103 27 ARF arf NN cord-015021-pol2qm74 6103 28 . . . cord-015021-pol2qm74 6104 1 ARF ARF NNP cord-015021-pol2qm74 6104 2 mortality mortality NN cord-015021-pol2qm74 6104 3 was be VBD cord-015021-pol2qm74 6104 4 52 52 CD cord-015021-pol2qm74 6104 5 % % NN cord-015021-pol2qm74 6104 6 . . . cord-015021-pol2qm74 6105 1 Ninety ninety CD cord-015021-pol2qm74 6105 2 - - HYPH cord-015021-pol2qm74 6105 3 eight eight CD cord-015021-pol2qm74 6105 4 percent percent NN cord-015021-pol2qm74 6105 5 had have VBD cord-015021-pol2qm74 6105 6 other other JJ cord-015021-pol2qm74 6105 7 OSF OSF NNP cord-015021-pol2qm74 6105 8 . . . cord-015021-pol2qm74 6106 1 Overall overall RB cord-015021-pol2qm74 6106 2 , , , cord-015021-pol2qm74 6106 3 CF CF NNP cord-015021-pol2qm74 6106 4 , , , cord-015021-pol2qm74 6106 5 PF PF NNP cord-015021-pol2qm74 6106 6 , , , cord-015021-pol2qm74 6106 7 GF GF NNP cord-015021-pol2qm74 6106 8 , , , cord-015021-pol2qm74 6106 9 and and CC cord-015021-pol2qm74 6106 10 NF NF NNP cord-015021-pol2qm74 6106 11 was be VBD cord-015021-pol2qm74 6106 12 significantly significantly RB cord-015021-pol2qm74 6106 13 more more RBR cord-015021-pol2qm74 6106 14 common common JJ cord-015021-pol2qm74 6106 15 in in IN cord-015021-pol2qm74 6106 16 nonsurvivors nonsurvivor NNS cord-015021-pol2qm74 6106 17 than than IN cord-015021-pol2qm74 6106 18 in in IN cord-015021-pol2qm74 6106 19 survivors survivor NNS cord-015021-pol2qm74 6106 20 ( ( -LRB- cord-015021-pol2qm74 6106 21 all all DT cord-015021-pol2qm74 6106 22 , , , cord-015021-pol2qm74 6106 23 p p XX cord-015021-pol2qm74 6106 24 < < XX cord-015021-pol2qm74 6106 25 O,02 O,02 NNP cord-015021-pol2qm74 6106 26 ) ) -RRB- cord-015021-pol2qm74 6106 27 . . . cord-015021-pol2qm74 6107 1 Although although IN cord-015021-pol2qm74 6107 2 both both CC cord-015021-pol2qm74 6107 3 the the DT cord-015021-pol2qm74 6107 4 number number NN cord-015021-pol2qm74 6107 5 of of IN cord-015021-pol2qm74 6107 6 OSF OSF NNP cord-015021-pol2qm74 6107 7 before before RB cord-015021-pol2qm74 6107 8 and and CC cord-015021-pol2qm74 6107 9 after after IN cord-015021-pol2qm74 6107 10 ARF ARF NNP cord-015021-pol2qm74 6107 11 was be VBD cord-015021-pol2qm74 6107 12 higher high JJR cord-015021-pol2qm74 6107 13 in in IN cord-015021-pol2qm74 6107 14 nonsurvivors nonsurvivor NNS cord-015021-pol2qm74 6107 15 than than IN cord-015021-pol2qm74 6107 16 in in IN cord-015021-pol2qm74 6107 17 survivors survivor NNS cord-015021-pol2qm74 6107 18 ( ( -LRB- cord-015021-pol2qm74 6107 19 p<0.02 p<0.02 NNP cord-015021-pol2qm74 6107 20 ) ) -RRB- cord-015021-pol2qm74 6107 21 , , , cord-015021-pol2qm74 6107 22 the the DT cord-015021-pol2qm74 6107 23 number number NN cord-015021-pol2qm74 6107 24 of of IN cord-015021-pol2qm74 6107 25 OSF OSF NNP cord-015021-pol2qm74 6107 26 before before RB cord-015021-pol2qm74 6107 27 was be VBD cord-015021-pol2qm74 6107 28 higher high JJR cord-015021-pol2qm74 6107 29 compared compare VBN cord-015021-pol2qm74 6107 30 to to IN cord-015021-pol2qm74 6107 31 after after IN cord-015021-pol2qm74 6107 32 ARF ARF NNP cord-015021-pol2qm74 6107 33 in in IN cord-015021-pol2qm74 6107 34 both both DT cord-015021-pol2qm74 6107 35 groups group NNS cord-015021-pol2qm74 6107 36 of of IN cord-015021-pol2qm74 6107 37 patients patient NNS cord-015021-pol2qm74 6107 38 ( ( -LRB- cord-015021-pol2qm74 6107 39 p<0.001 p<0.001 CD cord-015021-pol2qm74 6107 40 ) ) -RRB- cord-015021-pol2qm74 6107 41 . . . cord-015021-pol2qm74 6108 1 Furthermore furthermore RB cord-015021-pol2qm74 6108 2 , , , cord-015021-pol2qm74 6108 3 age age NN cord-015021-pol2qm74 6108 4 , , , cord-015021-pol2qm74 6108 5 CF CF NNP cord-015021-pol2qm74 6108 6 and and CC cord-015021-pol2qm74 6108 7 PF PF NNP cord-015021-pol2qm74 6108 8 before before IN cord-015021-pol2qm74 6108 9 the the DT cord-015021-pol2qm74 6108 10 ontset ontset NN cord-015021-pol2qm74 6108 11 of of IN cord-015021-pol2qm74 6108 12 ARF ARF NNP cord-015021-pol2qm74 6108 13 , , , cord-015021-pol2qm74 6108 14 NF NF NNP cord-015021-pol2qm74 6108 15 thereafter thereafter RB cord-015021-pol2qm74 6108 16 , , , cord-015021-pol2qm74 6108 17 and and CC cord-015021-pol2qm74 6108 18 renal renal JJ cord-015021-pol2qm74 6108 19 replacement replacement NN cord-015021-pol2qm74 6108 20 therapy therapy NN cord-015021-pol2qm74 6108 21 were be VBD cord-015021-pol2qm74 6108 22 related relate VBN cord-015021-pol2qm74 6108 23 to to IN cord-015021-pol2qm74 6108 24 mortality mortality NN cord-015021-pol2qm74 6108 25 ( ( -LRB- cord-015021-pol2qm74 6108 26 all all DT cord-015021-pol2qm74 6108 27 , , , cord-015021-pol2qm74 6108 28 p<0.03 p<0.03 NN cord-015021-pol2qm74 6108 29 ) ) -RRB- cord-015021-pol2qm74 6108 30 . . . cord-015021-pol2qm74 6109 1 However however RB cord-015021-pol2qm74 6109 2 , , , cord-015021-pol2qm74 6109 3 prior prior JJ cord-015021-pol2qm74 6109 4 chronic chronic JJ cord-015021-pol2qm74 6109 5 disease disease NN cord-015021-pol2qm74 6109 6 was be VBD cord-015021-pol2qm74 6109 7 not not RB cord-015021-pol2qm74 6109 8 related relate VBN cord-015021-pol2qm74 6109 9 to to IN cord-015021-pol2qm74 6109 10 mortality mortality NN cord-015021-pol2qm74 6109 11 and and CC cord-015021-pol2qm74 6109 12 chronic chronic JJ cord-015021-pol2qm74 6109 13 renal renal JJ cord-015021-pol2qm74 6109 14 insufficiency insufficiency NN cord-015021-pol2qm74 6109 15 was be VBD cord-015021-pol2qm74 6109 16 inversely inversely RB cord-015021-pol2qm74 6109 17 related relate VBN cord-015021-pol2qm74 6109 18 to to IN cord-015021-pol2qm74 6109 19 outcome outcome NN cord-015021-pol2qm74 6109 20 ( ( -LRB- cord-015021-pol2qm74 6109 21 p<0.002 p<0.002 CD cord-015021-pol2qm74 6109 22 ) ) -RRB- cord-015021-pol2qm74 6109 23 . . . cord-015021-pol2qm74 6110 1 After after IN cord-015021-pol2qm74 6110 2 multiple multiple JJ cord-015021-pol2qm74 6110 3 logistic logistic JJ cord-015021-pol2qm74 6110 4 regression regression NN cord-015021-pol2qm74 6110 5 , , , cord-015021-pol2qm74 6110 6 advancing advance VBG cord-015021-pol2qm74 6110 7 age age NN cord-015021-pol2qm74 6110 8 , , , cord-015021-pol2qm74 6110 9 cardiopulrnonary cardiopulrnonary JJ cord-015021-pol2qm74 6110 10 failure failure NN cord-015021-pol2qm74 6110 11 and and CC cord-015021-pol2qm74 6110 12 sepsis sepsis NN cord-015021-pol2qm74 6110 13 before before IN cord-015021-pol2qm74 6110 14 ARF ARF NNP cord-015021-pol2qm74 6110 15 , , , cord-015021-pol2qm74 6110 16 and and CC cord-015021-pol2qm74 6110 17 NF nf NN cord-015021-pol2qm74 6110 18 after after IN cord-015021-pol2qm74 6110 19 ARF ARF NNP cord-015021-pol2qm74 6110 20 remained remain VBD cord-015021-pol2qm74 6110 21 significant significant JJ cord-015021-pol2qm74 6110 22 . . . cord-015021-pol2qm74 6111 1 These these DT cord-015021-pol2qm74 6111 2 results result NNS cord-015021-pol2qm74 6111 3 show show VBP cord-015021-pol2qm74 6111 4 the the DT cord-015021-pol2qm74 6111 5 high high JJ cord-015021-pol2qm74 6111 6 prevalence prevalence NN cord-015021-pol2qm74 6111 7 of of IN cord-015021-pol2qm74 6111 8 ARF arf NN cord-015021-pol2qm74 6111 9 in in IN cord-015021-pol2qm74 6111 10 critically critically RB cord-015021-pol2qm74 6111 11 ill ill JJ cord-015021-pol2qm74 6111 12 patients patient NNS cord-015021-pol2qm74 6111 13 and and CC cord-015021-pol2qm74 6111 14 that that IN cord-015021-pol2qm74 6111 15 ARF ARF NNP cord-015021-pol2qm74 6111 16 rarely rarely RB cord-015021-pol2qm74 6111 17 occurs occur VBZ cord-015021-pol2qm74 6111 18 alone alone RB cord-015021-pol2qm74 6111 19 . . . cord-015021-pol2qm74 6112 1 The the DT cord-015021-pol2qm74 6112 2 prognosis prognosis NN cord-015021-pol2qm74 6112 3 of of IN cord-015021-pol2qm74 6112 4 ARF ARF NNP cord-015021-pol2qm74 6112 5 in in IN cord-015021-pol2qm74 6112 6 critically critically RB cord-015021-pol2qm74 6112 7 ill ill JJ cord-015021-pol2qm74 6112 8 patients patient NNS cord-015021-pol2qm74 6112 9 is be VBZ cord-015021-pol2qm74 6112 10 poor poor JJ cord-015021-pol2qm74 6112 11 , , , cord-015021-pol2qm74 6112 12 especially especially RB cord-015021-pol2qm74 6112 13 if if IN cord-015021-pol2qm74 6112 14 associated associate VBN cord-015021-pol2qm74 6112 15 with with IN cord-015021-pol2qm74 6112 16 advancing advance VBG cord-015021-pol2qm74 6112 17 age age NN cord-015021-pol2qm74 6112 18 , , , cord-015021-pol2qm74 6112 19 additional additional JJ cord-015021-pol2qm74 6112 20 OSF OSF NNP cord-015021-pol2qm74 6112 21 , , , cord-015021-pol2qm74 6112 22 particularly particularly RB cord-015021-pol2qm74 6112 23 cardiopulmonary cardiopulmonary JJ cord-015021-pol2qm74 6112 24 failure failure NN cord-015021-pol2qm74 6112 25 and and CC cord-015021-pol2qm74 6112 26 sepsis sepsis NN cord-015021-pol2qm74 6112 27 before before IN cord-015021-pol2qm74 6112 28 ARF ARF NNP cord-015021-pol2qm74 6112 29 , , , cord-015021-pol2qm74 6112 30 and and CC cord-015021-pol2qm74 6112 31 NF nf NN cord-015021-pol2qm74 6112 32 after after IN cord-015021-pol2qm74 6112 33 ARF ARF NNP cord-015021-pol2qm74 6112 34 . . . cord-015021-pol2qm74 6113 1 Hence hence RB cord-015021-pol2qm74 6113 2 , , , cord-015021-pol2qm74 6113 3 prevention prevention NN cord-015021-pol2qm74 6113 4 of of IN cord-015021-pol2qm74 6113 5 cardiopulmonary cardiopulmonary JJ cord-015021-pol2qm74 6113 6 and and CC cord-015021-pol2qm74 6113 7 sepsis sepsis NN cord-015021-pol2qm74 6113 8 before before IN cord-015021-pol2qm74 6113 9 the the DT cord-015021-pol2qm74 6113 10 outset outset NN cord-015021-pol2qm74 6113 11 of of IN cord-015021-pol2qm74 6113 12 ARF ARF NNP cord-015021-pol2qm74 6113 13 may may MD cord-015021-pol2qm74 6113 14 influence influence VB cord-015021-pol2qm74 6113 15 outcome outcome NN cord-015021-pol2qm74 6113 16 in in IN cord-015021-pol2qm74 6113 17 ARF arf NN cord-015021-pol2qm74 6113 18 in in IN cord-015021-pol2qm74 6113 19 patients patient NNS cord-015021-pol2qm74 6113 20 with with IN cord-015021-pol2qm74 6113 21 critical critical JJ cord-015021-pol2qm74 6113 22 illness illness NN cord-015021-pol2qm74 6113 23 . . . cord-015021-pol2qm74 6114 1 The the DT cord-015021-pol2qm74 6114 2 search search NN cord-015021-pol2qm74 6114 3 cominnes cominne NNS cord-015021-pol2qm74 6114 4 for for IN cord-015021-pol2qm74 6114 5 a a DT cord-015021-pol2qm74 6114 6 magic magic JJ cord-015021-pol2qm74 6114 7 bullet bullet NN cord-015021-pol2qm74 6114 8 ta ta PRP cord-015021-pol2qm74 6114 9 help help VB cord-015021-pol2qm74 6114 10 critically critically RB cord-015021-pol2qm74 6114 11 ill ill JJ cord-015021-pol2qm74 6114 12 petienta petienta NNS cord-015021-pol2qm74 6114 13 , , , cord-015021-pol2qm74 6114 14 bat bat VB cord-015021-pol2qm74 6114 15 recent recent JJ cord-015021-pol2qm74 6114 16 elini elini NN cord-015021-pol2qm74 6114 17 ' ' '' cord-015021-pol2qm74 6114 18 , , . cord-015021-pol2qm74 6115 1 .ml .ml . cord-015021-pol2qm74 6116 1 1rials 1rials CD cord-015021-pol2qm74 6116 2 of of IN cord-015021-pol2qm74 6116 3 agents agent NNS cord-015021-pol2qm74 6116 4 that that WDT cord-015021-pol2qm74 6116 5 showed show VBD cord-015021-pol2qm74 6116 6 Ixomise Ixomise NNP cord-015021-pol2qm74 6116 7 in in IN cord-015021-pol2qm74 6116 8 animal animal NN cord-015021-pol2qm74 6116 9 studies study NNS cord-015021-pol2qm74 6116 10 raise raise VBP cord-015021-pol2qm74 6116 11 questions question NNS cord-015021-pol2qm74 6116 12 about about IN cord-015021-pol2qm74 6116 13 such such JJ cord-015021-pol2qm74 6116 14 trials trial NNS cord-015021-pol2qm74 6116 15 . . . cord-015021-pol2qm74 6117 1 ExpcrlmemaI ExpcrlmemaI NNP cord-015021-pol2qm74 6118 1 uvidan~ uvidan~ NN cord-015021-pol2qm74 6118 2 : : : cord-015021-pol2qm74 6119 1 in in IN cord-015021-pol2qm74 6119 2 anlmats anlmat NNS cord-015021-pol2qm74 6119 3 and and CC cord-015021-pol2qm74 6119 4 human human JJ cord-015021-pol2qm74 6119 5 volanteet~ volanteet~ NN cord-015021-pol2qm74 6119 6 for for IN cord-015021-pol2qm74 6119 7 concepts concept NNS cord-015021-pol2qm74 6119 8 , , , cord-015021-pol2qm74 6119 9 mechanisms mechanism NNS cord-015021-pol2qm74 6119 10 and and CC cord-015021-pol2qm74 6119 11 treatment treatment NN cord-015021-pol2qm74 6119 12 of of IN cord-015021-pol2qm74 6119 13 inju~ inju~ NN cord-015021-pol2qm74 6119 14 ur ur JJ cord-015021-pol2qm74 6119 15 illness illness NN cord-015021-pol2qm74 6119 16 can can MD cord-015021-pol2qm74 6119 17 be be VB cord-015021-pol2qm74 6119 18 substentlal substentlal NN cord-015021-pol2qm74 6119 19 , , . cord-015021-pol2qm74 6120 1 l l NNP cord-015021-pol2qm74 6120 2 ~ ~ CD cord-015021-pol2qm74 6120 3 rauasive rauasive NN cord-015021-pol2qm74 6120 4 and and CC cord-015021-pol2qm74 6120 5 exciting exciting JJ cord-015021-pol2qm74 6120 6 but but CC cord-015021-pol2qm74 6120 7 the the DT cord-015021-pol2qm74 6120 8 positive positive JJ cord-015021-pol2qm74 6120 9 effects effect NNS cord-015021-pol2qm74 6120 10 of of IN cord-015021-pol2qm74 6120 11 potential potential JJ cord-015021-pol2qm74 6120 12 therapy therapy NN cord-015021-pol2qm74 6120 13 suggested suggest VBN cord-015021-pol2qm74 6120 14 by by IN cord-015021-pol2qm74 6120 15 such such JJ cord-015021-pol2qm74 6120 16 animal animal NN cord-015021-pol2qm74 6120 17 and and CC cord-015021-pol2qm74 6120 18 ctinieal ctinieal JJ cord-015021-pol2qm74 6120 19 research research NN cord-015021-pol2qm74 6120 20 may may MD cord-015021-pol2qm74 6120 21 be be VB cord-015021-pol2qm74 6120 22 difficult difficult JJ cord-015021-pol2qm74 6120 23 to to TO cord-015021-pol2qm74 6120 24 prove prove VB cord-015021-pol2qm74 6120 25 in in IN cord-015021-pol2qm74 6120 26 sick sick JJ cord-015021-pol2qm74 6120 27 patients patient NNS cord-015021-pol2qm74 6120 28 . . . cord-015021-pol2qm74 6121 1 Efficacy efficacy NN cord-015021-pol2qm74 6121 2 of of IN cord-015021-pol2qm74 6121 3 a a DT cord-015021-pol2qm74 6121 4 new new JJ cord-015021-pol2qm74 6121 5 txeatment txeatment NN cord-015021-pol2qm74 6121 6 can can MD cord-015021-pol2qm74 6121 7 be be VB cord-015021-pol2qm74 6121 8 difficult difficult JJ cord-015021-pol2qm74 6121 9 to to TO cord-015021-pol2qm74 6121 10 prove prove VB cord-015021-pol2qm74 6121 11 became become VBN cord-015021-pol2qm74 6121 12 elinie.al elinie.al CD cord-015021-pol2qm74 6121 13 situations situation NNS cord-015021-pol2qm74 6121 14 , , , cord-015021-pol2qm74 6121 15 hi hi UH cord-015021-pol2qm74 6121 16 spi spi NNP cord-015021-pol2qm74 6121 17 ~ ~ NNP cord-015021-pol2qm74 6121 18 e e NNP cord-015021-pol2qm74 6121 19 of of IN cord-015021-pol2qm74 6121 20 important important JJ cord-015021-pol2qm74 6121 21 biologic biologic JJ cord-015021-pol2qm74 6121 22 phenomena phenomenon NNS cord-015021-pol2qm74 6121 23 , , , cord-015021-pol2qm74 6121 24 are be VBP cord-015021-pol2qm74 6121 25 v v LS cord-015021-pol2qm74 6121 26 ~ ~ NFP cord-015021-pol2qm74 6121 27 iable iable NNP cord-015021-pol2qm74 6121 28 and and CC cord-015021-pol2qm74 6121 29 conrplex conrplex NNP cord-015021-pol2qm74 6121 30 . . . cord-015021-pol2qm74 6122 1 There there EX cord-015021-pol2qm74 6122 2 is be VBZ cord-015021-pol2qm74 6122 3 redundancy redundancy NN cord-015021-pol2qm74 6122 4 and and CC cord-015021-pol2qm74 6122 5 overlap overlap NN cord-015021-pol2qm74 6122 6 of of IN cord-015021-pol2qm74 6122 7 mediators mediator NNS cord-015021-pol2qm74 6123 1 ~d ~d . cord-015021-pol2qm74 6124 1 problems problem NNS cord-015021-pol2qm74 6124 2 of of IN cord-015021-pol2qm74 6124 3 timing timing NN cord-015021-pol2qm74 6124 4 of of IN cord-015021-pol2qm74 6124 5 therapy therapy NN cord-015021-pol2qm74 6124 6 . . . cord-015021-pol2qm74 6125 1 A a DT cord-015021-pol2qm74 6125 2 majt majt NN cord-015021-pol2qm74 6125 3 ~ ~ NFP cord-015021-pol2qm74 6125 4 r r NN cord-015021-pol2qm74 6125 5 cause cause NN cord-015021-pol2qm74 6125 6 of of IN cord-015021-pol2qm74 6125 7 this this DT cord-015021-pol2qm74 6125 8 dilemtns dilemtns NN cord-015021-pol2qm74 6125 9 is be VBZ cord-015021-pol2qm74 6125 10 not not RB cord-015021-pol2qm74 6125 11 with with IN cord-015021-pol2qm74 6125 12 the the DT cord-015021-pol2qm74 6125 13 trials trial NNS cord-015021-pol2qm74 6125 14 or or CC cord-015021-pol2qm74 6125 15 hypotheses hypothesis NNS cord-015021-pol2qm74 6125 16 , , , cord-015021-pol2qm74 6125 17 but but CC cord-015021-pol2qm74 6125 18 rather rather RB cord-015021-pol2qm74 6125 19 the the DT cord-015021-pol2qm74 6125 20 proMem promem NN cord-015021-pol2qm74 6125 21 of of IN cord-015021-pol2qm74 6125 22 the the DT cord-015021-pol2qm74 6125 23 cause cause NN cord-015021-pol2qm74 6125 24 or or CC cord-015021-pol2qm74 6125 25 the the DT cord-015021-pol2qm74 6125 26 causability causability NN cord-015021-pol2qm74 6125 27 of of IN cord-015021-pol2qm74 6125 28 the the DT cord-015021-pol2qm74 6125 29 human human JJ cord-015021-pol2qm74 6125 30 dise~.se dise~.se NNS cord-015021-pol2qm74 6125 31 that that WDT cord-015021-pol2qm74 6125 32 is be VBZ cord-015021-pol2qm74 6125 33 trebled treble VBN cord-015021-pol2qm74 6125 34 . . . cord-015021-pol2qm74 6126 1 This this DT cord-015021-pol2qm74 6126 2 is be VBZ cord-015021-pol2qm74 6126 3 / / SYM cord-015021-pol2qm74 6126 4 hu hu NNP cord-015021-pol2qm74 6126 5 " " `` cord-015021-pol2qm74 6126 6 causa causa NNP cord-015021-pol2qm74 6126 7 nets net NNS cord-015021-pol2qm74 6126 8 " " '' cord-015021-pol2qm74 6126 9 or or CC cord-015021-pol2qm74 6126 10 ' ' `` cord-015021-pol2qm74 6126 11 * * NFP cord-015021-pol2qm74 6126 12 specific specific JJ cord-015021-pol2qm74 6126 13 cause cause NN cord-015021-pol2qm74 6126 14 " " '' cord-015021-pol2qm74 6126 15 as as IN cord-015021-pol2qm74 6126 16 described describe VBN cord-015021-pol2qm74 6126 17 by by IN cord-015021-pol2qm74 6126 18 Stehbens Stehbens NNP cord-015021-pol2qm74 6126 19 , , , cord-015021-pol2qm74 6126 20 When when WRB cord-015021-pol2qm74 6126 21 prevention prevention NN cord-015021-pol2qm74 6126 22 or or CC cord-015021-pol2qm74 6126 23 tre.atmcnt tre.atmcnt NNP cord-015021-pol2qm74 6126 24 is be VBZ cord-015021-pol2qm74 6126 25 based base VBN cord-015021-pol2qm74 6126 26 em -PRON- PRP cord-015021-pol2qm74 6127 1 the the DT cord-015021-pol2qm74 6127 2 sauna sauna NN cord-015021-pol2qm74 6127 3 nero nero NNP cord-015021-pol2qm74 6127 4 , , , cord-015021-pol2qm74 6127 5 extinetiem extinetiem NNP cord-015021-pol2qm74 6127 6 of of IN cord-015021-pol2qm74 6127 7 the the DT cord-015021-pol2qm74 6127 8 disease disease NN cord-015021-pol2qm74 6127 9 is be VBZ cord-015021-pol2qm74 6127 10 Ix Ix NNP cord-015021-pol2qm74 6128 1 ~ssible ~ssible JJ cord-015021-pol2qm74 6128 2 as as IN cord-015021-pol2qm74 6128 3 with with IN cord-015021-pol2qm74 6128 4 saul/ saul/ ADD cord-015021-pol2qm74 6128 5 pox pox NN cord-015021-pol2qm74 6128 6 . . . cord-015021-pol2qm74 6129 1 Only only RB cord-015021-pol2qm74 6129 2 elimination elimination NN cord-015021-pol2qm74 6129 3 of of IN cord-015021-pol2qm74 6129 4 the the DT cord-015021-pol2qm74 6129 5 cause cause NN cord-015021-pol2qm74 6129 6 wl12 wl12 NNP cord-015021-pol2qm74 6129 7 cure cure VB cord-015021-pol2qm74 6129 8 the the DT cord-015021-pol2qm74 6129 9 disease disease NN cord-015021-pol2qm74 6129 10 . . . cord-015021-pol2qm74 6130 1 Careful careful JJ cord-015021-pol2qm74 6130 2 animal animal NN cord-015021-pol2qm74 6130 3 studit studit NNP cord-015021-pol2qm74 6130 4 ~ ~ NFP cord-015021-pol2qm74 6130 5 s s PRP cord-015021-pol2qm74 6130 6 evaluate evaluate VB cord-015021-pol2qm74 6130 7 single single JJ cord-015021-pol2qm74 6130 8 pcrturbmiuns pcrturbmiun NNS cord-015021-pol2qm74 6130 9 for for IN cord-015021-pol2qm74 6130 10 survival survival NN cord-015021-pol2qm74 6130 11 or or CC cord-015021-pol2qm74 6130 12 other other JJ cord-015021-pol2qm74 6130 13 changes change NNS cord-015021-pol2qm74 6130 14 . . . cord-015021-pol2qm74 6131 1 An an DT cord-015021-pol2qm74 6131 2 LDso LDso NNP cord-015021-pol2qm74 6131 3 preparation preparation NN cord-015021-pol2qm74 6131 4 may may MD cord-015021-pol2qm74 6131 5 be be VB cord-015021-pol2qm74 6131 6 infiuancad infiuancad NNP cord-015021-pol2qm74 6131 7 aignificantly aignificantly RB cord-015021-pol2qm74 6131 8 by by IN cord-015021-pol2qm74 6131 9 a a DT cord-015021-pol2qm74 6131 10 ~mall ~mall NNP cord-015021-pol2qm74 6131 11 clangs clang NNS cord-015021-pol2qm74 6131 12 which which WDT cord-015021-pol2qm74 6131 13 may may MD cord-015021-pol2qm74 6131 14 be be VB cord-015021-pol2qm74 6131 15 insignific insignific JJ cord-015021-pol2qm74 6132 1 ~lt ~lt NNP cord-015021-pol2qm74 6132 2 ht ht NNP cord-015021-pol2qm74 6132 3 pstiants pstiants NNP cord-015021-pol2qm74 6132 4 , , , cord-015021-pol2qm74 6132 5 Most Most JJS cord-015021-pol2qm74 6132 6 human human JJ cord-015021-pol2qm74 6132 7 experiments experiment NNS cord-015021-pol2qm74 6132 8 ate eat VBD cord-015021-pol2qm74 6132 9 carried carry VBN cord-015021-pol2qm74 6132 10 out out RP cord-015021-pol2qm74 6132 11 in in IN cord-015021-pol2qm74 6132 12 normal normal JJ cord-015021-pol2qm74 6132 13 volunleers volunleer NNS cord-015021-pol2qm74 6132 14 with with IN cord-015021-pol2qm74 6132 15 a a DT cord-015021-pol2qm74 6132 16 single single JJ cord-015021-pol2qm74 6132 17 porlurbation porlurbation NN cord-015021-pol2qm74 6132 18 , , , cord-015021-pol2qm74 6132 19 such such JJ cord-015021-pol2qm74 6132 20 as as IN cord-015021-pol2qm74 6132 21 a a DT cord-015021-pol2qm74 6132 22 low low JJ cord-015021-pol2qm74 6132 23 - - HYPH cord-015021-pol2qm74 6132 24 level level NN cord-015021-pol2qm74 6132 25 , , , cord-015021-pol2qm74 6132 26 non non JJ cord-015021-pol2qm74 6132 27 - - JJ cord-015021-pol2qm74 6132 28 lethal lethal JJ cord-015021-pol2qm74 6132 29 dose dose NN cord-015021-pol2qm74 6132 30 of of IN cord-015021-pol2qm74 6132 31 a a DT cord-015021-pol2qm74 6132 32 substance substance NN cord-015021-pol2qm74 6132 33 . . . cord-015021-pol2qm74 6133 1 Such such JJ cord-015021-pol2qm74 6133 2 studies study NNS cord-015021-pol2qm74 6133 3 are be VBP cord-015021-pol2qm74 6133 4 huportant huportant JJ cord-015021-pol2qm74 6133 5 in in IN cord-015021-pol2qm74 6133 6 defining define VBG cord-015021-pol2qm74 6133 7 mechanisms mechanism NNS cord-015021-pol2qm74 6133 8 attd attd NN cord-015021-pol2qm74 6133 9 mediators mediator NNS cord-015021-pol2qm74 6133 10 of of IN cord-015021-pol2qm74 6133 11 disease disease NN cord-015021-pol2qm74 6133 12 , , , cord-015021-pol2qm74 6133 13 In in IN cord-015021-pol2qm74 6133 14 our -PRON- PRP$ cord-015021-pol2qm74 6133 15 world world NN cord-015021-pol2qm74 6133 16 of of IN cord-015021-pol2qm74 6133 17 injm'ed injm'ed NN cord-015021-pol2qm74 6133 18 , , , cord-015021-pol2qm74 6133 19 operated operate VBN cord-015021-pol2qm74 6133 20 , , , cord-015021-pol2qm74 6133 21 infected infected JJ cord-015021-pol2qm74 6133 22 and and CC cord-015021-pol2qm74 6133 23 inflslned inflslned JJ cord-015021-pol2qm74 6133 24 patients patient NNS cord-015021-pol2qm74 6133 25 , , , cord-015021-pol2qm74 6133 26 there there EX cord-015021-pol2qm74 6133 27 are be VBP cord-015021-pol2qm74 6133 28 many many JJ cord-015021-pol2qm74 6133 29 diseases disease NNS cord-015021-pol2qm74 6133 30 , , , cord-015021-pol2qm74 6133 31 MOF MOF NNP cord-015021-pol2qm74 6133 32 is be VBZ cord-015021-pol2qm74 6133 33 not not RB cord-015021-pol2qm74 6133 34 one one CD cord-015021-pol2qm74 6133 35 of of IN cord-015021-pol2qm74 6133 36 lhem lhem NN cord-015021-pol2qm74 6133 37 . . . cord-015021-pol2qm74 6134 1 it -PRON- PRP cord-015021-pol2qm74 6134 2 is be VBZ cord-015021-pol2qm74 6134 3 n't not RB cord-015021-pol2qm74 6134 4 even even RB cord-015021-pol2qm74 6134 5 a a DT cord-015021-pol2qm74 6134 6 syndrume syndrume NN cord-015021-pol2qm74 6134 7 , , , cord-015021-pol2qm74 6134 8 It -PRON- PRP cord-015021-pol2qm74 6134 9 is be VBZ cord-015021-pol2qm74 6134 10 the the DT cord-015021-pol2qm74 6134 11 final final JJ cord-015021-pol2qm74 6134 12 pathway pathway NN cord-015021-pol2qm74 6134 13 for for IN cord-015021-pol2qm74 6134 14 a a DT cord-015021-pol2qm74 6134 15 number number NN cord-015021-pol2qm74 6134 16 of of IN cord-015021-pol2qm74 6134 17 diseaaes~ diseaaes~ NNP cord-015021-pol2qm74 6134 18 each each DT cord-015021-pol2qm74 6134 19 of of IN cord-015021-pol2qm74 6134 20 which which WDT cord-015021-pol2qm74 6134 21 has have VBZ cord-015021-pol2qm74 6134 22 a a DT cord-015021-pol2qm74 6134 23 cause cause NN cord-015021-pol2qm74 6134 24 . . . cord-015021-pol2qm74 6135 1 MeCormock MeCormock NNP cord-015021-pol2qm74 6135 2 believes believe VBZ cord-015021-pol2qm74 6135 3 thal thal NNP cord-015021-pol2qm74 6135 4 a a DT cord-015021-pol2qm74 6135 5 " " `` cord-015021-pol2qm74 6135 6 multi multi JJ cord-015021-pol2qm74 6135 7 - - JJ cord-015021-pol2qm74 6135 8 causal causal JJ cord-015021-pol2qm74 6135 9 " " '' cord-015021-pol2qm74 6135 10 etiology etiology NN cord-015021-pol2qm74 6135 11 is be VBZ cord-015021-pol2qm74 6135 12 a a DT cord-015021-pol2qm74 6135 13 euphemism euphemism NN cord-015021-pol2qm74 6135 14 for for IN cord-015021-pol2qm74 6135 15 ignoranc ignoranc NNP cord-015021-pol2qm74 6135 16 # # NN cord-015021-pol2qm74 6135 17 or or CC cord-015021-pol2qm74 6135 18 a a DT cord-015021-pol2qm74 6135 19 synonym synonym JJ cord-015021-pol2qm74 6135 20 fo~ fo~ NN cord-015021-pol2qm74 6135 21 unknown unknown JJ cord-015021-pol2qm74 6135 22 etiology etiology NN cord-015021-pol2qm74 6135 23 . . . cord-015021-pol2qm74 6136 1 Admission admission NN cord-015021-pol2qm74 6136 2 Iv Iv NNP cord-015021-pol2qm74 6136 3 sn sn NNP cord-015021-pol2qm74 6136 4 ICU ICU NNP cord-015021-pol2qm74 6136 5 , , , cord-015021-pol2qm74 6136 6 a a DT cord-015021-pol2qm74 6136 7 high high JJ cord-015021-pol2qm74 6136 8 APACHE apache NN cord-015021-pol2qm74 6136 9 seer% seer% , cord-015021-pol2qm74 6136 10 the the DT cord-015021-pol2qm74 6136 11 sepsis sepsis NN cord-015021-pol2qm74 6136 12 syndrome syndrome NN cord-015021-pol2qm74 6136 13 , , , cord-015021-pol2qm74 6136 14 MOF MOF NNP cord-015021-pol2qm74 6136 15 , , , cord-015021-pol2qm74 6136 16 MUDS MUDS NNPS cord-015021-pol2qm74 6136 17 , , , cord-015021-pol2qm74 6136 18 or or CC cord-015021-pol2qm74 6136 19 SIRS SIRS NNP cord-015021-pol2qm74 6136 20 and and CC cord-015021-pol2qm74 6136 21 having have VBG cord-015021-pol2qm74 6136 22 predictors predictor NNS cord-015021-pol2qm74 6136 23 indicating indicate VBG cord-015021-pol2qm74 6136 24 potential potential JJ cord-015021-pol2qm74 6136 25 mortality mortality NN cord-015021-pol2qm74 6136 26 , , , cord-015021-pol2qm74 6136 27 are be VBP cord-015021-pol2qm74 6136 28 not not RB cord-015021-pol2qm74 6136 29 diseases disease NNS cord-015021-pol2qm74 6136 30 . . . cord-015021-pol2qm74 6137 1 The the DT cord-015021-pol2qm74 6137 2 inmpors inmpor NNS cord-015021-pol2qm74 6137 3 are be VBP cord-015021-pol2qm74 6137 4 getting get VBG cord-015021-pol2qm74 6137 5 negative negative JJ cord-015021-pol2qm74 6137 6 results result NNS cord-015021-pol2qm74 6137 7 in in IN cord-015021-pol2qm74 6137 8 trials trial NNS cord-015021-pol2qm74 6137 9 of of IN cord-015021-pol2qm74 6137 10 agents agent NNS cord-015021-pol2qm74 6137 11 on on IN cord-015021-pol2qm74 6137 12 eiek eiek NNP cord-015021-pol2qm74 6137 13 or or CC cord-015021-pol2qm74 6137 14 septic septic JJ cord-015021-pol2qm74 6137 15 ICU ICU NNP cord-015021-pol2qm74 6137 16 patients patient NNS cord-015021-pol2qm74 6137 17 and and CC cord-015021-pol2qm74 6137 18 aru aru NNP cord-015021-pol2qm74 6137 19 now now RB cord-015021-pol2qm74 6137 20 becoming become VBG cord-015021-pol2qm74 6137 21 splitters splitter NNS cord-015021-pol2qm74 6137 22 , , , cord-015021-pol2qm74 6137 23 dafining dafine VBG cord-015021-pol2qm74 6137 24 subgaoups subgaoups NNP cord-015021-pol2qm74 6137 25 at at IN cord-015021-pol2qm74 6137 26 higher high JJR cord-015021-pol2qm74 6137 27 risk risk NN cord-015021-pol2qm74 6137 28 for for IN cord-015021-pol2qm74 6137 29 death death NN cord-015021-pol2qm74 6137 30 . . . cord-015021-pol2qm74 6138 1 Such such JJ cord-015021-pol2qm74 6138 2 an an DT cord-015021-pol2qm74 6138 3 approach approach NN cord-015021-pol2qm74 6138 4 may may MD cord-015021-pol2qm74 6138 5 produce produce VB cord-015021-pol2qm74 6138 6 positive positive JJ cord-015021-pol2qm74 6138 7 results result NNS cord-015021-pol2qm74 6138 8 if if IN cord-015021-pol2qm74 6138 9 the the DT cord-015021-pol2qm74 6138 10 diseases disease NNS cord-015021-pol2qm74 6138 11 are be VBP cord-015021-pol2qm74 6138 12 identified identify VBN cord-015021-pol2qm74 6138 13 and and CC cord-015021-pol2qm74 6138 14 the the DT cord-015021-pol2qm74 6138 15 treatmeul treatmeul NN cord-015021-pol2qm74 6138 16 is be VBZ cord-015021-pol2qm74 6138 17 specific specific JJ cord-015021-pol2qm74 6138 18 for for IN cord-015021-pol2qm74 6138 19 them -PRON- PRP cord-015021-pol2qm74 6138 20 , , , cord-015021-pol2qm74 6138 21 A a DT cord-015021-pol2qm74 6138 22 major major JJ cord-015021-pol2qm74 6138 23 challenge challenge NN cord-015021-pol2qm74 6138 24 in in IN cord-015021-pol2qm74 6138 25 deterraintng deterraintng NN cord-015021-pol2qm74 6138 26 the the DT cord-015021-pol2qm74 6138 27 efficacy efficacy NN cord-015021-pol2qm74 6138 28 of of IN cord-015021-pol2qm74 6138 29 new new JJ cord-015021-pol2qm74 6138 30 therapies therapy NNS cord-015021-pol2qm74 6138 31 for for IN cord-015021-pol2qm74 6138 32 sepsis sepsis NN cord-015021-pol2qm74 6138 33 nnd nnd NNP cord-015021-pol2qm74 6138 34 shock shock NN cord-015021-pol2qm74 6138 35 Is be VBZ cord-015021-pol2qm74 6138 36 Identifying identify VBG cord-015021-pol2qm74 6138 37 patients patient NNS cord-015021-pol2qm74 6138 38 whose whose WP$ cord-015021-pol2qm74 6138 39 e#temtc e#temtc CD cord-015021-pol2qm74 6138 40 Inflammatory inflammatory JJ cord-015021-pol2qm74 6138 41 response response NN cord-015021-pol2qm74 6138 42 Is be VBZ cord-015021-pol2qm74 6138 43 appropriate appropriate JJ cord-015021-pol2qm74 6138 44 from from IN cord-015021-pol2qm74 6138 45 those those DT cord-015021-pol2qm74 6138 46 in in IN cord-015021-pol2qm74 6138 47 whom whom WP cord-015021-pol2qm74 6138 48 the the DT cord-015021-pol2qm74 6138 49 mediator| mediator| NNP cord-015021-pol2qm74 6138 50 are be VBP cord-015021-pol2qm74 6138 51 contributing contribute VBG cord-015021-pol2qm74 6138 52 to to TO cord-015021-pol2qm74 6138 53 end end VB cord-015021-pol2qm74 6138 54 organ organ NN cord-015021-pol2qm74 6138 55 system system NN cord-015021-pol2qm74 6138 56 damage damage NN cord-015021-pol2qm74 6138 57 end end NN cord-015021-pol2qm74 6138 58 death death NN cord-015021-pol2qm74 6138 59 , , , cord-015021-pol2qm74 6138 60 Traditional Traditional NNP cord-015021-pol2qm74 6138 61 and and CC cord-015021-pol2qm74 6138 62 recently recently RB cord-015021-pol2qm74 6138 63 revised revise VBD cord-015021-pol2qm74 6138 64 categorical categorical JJ cord-015021-pol2qm74 6138 65 patient patient NN cord-015021-pol2qm74 6138 66 descriptions description NNS cord-015021-pol2qm74 6138 67 such such JJ cord-015021-pol2qm74 6138 68 as as IN cord-015021-pol2qm74 6138 69 sepsis sepsis NN cord-015021-pol2qm74 6138 70 syndrome syndrome NN cord-015021-pol2qm74 6138 71 , , , cord-015021-pol2qm74 6139 1 sepsis sepsis NNP cord-015021-pol2qm74 6139 2 syndrome syndrome NN cord-015021-pol2qm74 6139 3 with with IN cord-015021-pol2qm74 6139 4 shock shock NN cord-015021-pol2qm74 6139 5 , , , cord-015021-pol2qm74 6139 6 multiple multiple JJ cord-015021-pol2qm74 6139 7 organ organ NN cord-015021-pol2qm74 6139 8 system system NN cord-015021-pol2qm74 6139 9 failure failure NN cord-015021-pol2qm74 6139 10 , , , cord-015021-pol2qm74 6139 11 or or CC cord-015021-pol2qm74 6139 12 the the DT cord-015021-pol2qm74 6139 13 recently recently RB cord-015021-pol2qm74 6139 14 proposed propose VBN cord-015021-pol2qm74 6139 15 systemic systemic JJ cord-015021-pol2qm74 6139 16 inflammatory inflammatory JJ cord-015021-pol2qm74 6139 17 response response NN cord-015021-pol2qm74 6139 18 syndrome syndrome NN cord-015021-pol2qm74 6139 19 ( ( -LRB- cord-015021-pol2qm74 6139 20 SIRS SIRS NNP cord-015021-pol2qm74 6139 21 ) ) -RRB- cord-015021-pol2qm74 6139 22 may may MD cord-015021-pol2qm74 6139 23 not not RB cord-015021-pol2qm74 6139 24 be be VB cord-015021-pol2qm74 6139 25 sufilcient sufilcient JJ cord-015021-pol2qm74 6139 26 since since IN cord-015021-pol2qm74 6139 27 they -PRON- PRP cord-015021-pol2qm74 6139 28 Identify identify VBP cord-015021-pol2qm74 6139 29 individuals individual NNS cord-015021-pol2qm74 6139 30 at at IN cord-015021-pol2qm74 6139 31 varying vary VBG cord-015021-pol2qm74 6139 32 levels level NNS cord-015021-pol2qm74 6139 33 of of IN cord-015021-pol2qm74 6139 34 risk risk NN cord-015021-pol2qm74 6139 35 for for IN cord-015021-pol2qm74 6139 36 short short JJ cord-015021-pol2qm74 6139 37 term term NN cord-015021-pol2qm74 6139 38 mortality mortality NN cord-015021-pol2qm74 6139 39 , , , cord-015021-pol2qm74 6139 40 The the DT cord-015021-pol2qm74 6139 41 efficacy efficacy NN cord-015021-pol2qm74 6139 42 of of IN cord-015021-pol2qm74 6139 43 new new JJ cord-015021-pol2qm74 6139 44 lmmunotherapy lmmunotherapy NNP cord-015021-pol2qm74 6139 45 may may MD cord-015021-pol2qm74 6139 46 be be VB cord-015021-pol2qm74 6139 47 directly directly RB cord-015021-pol2qm74 6139 48 related relate VBN cord-015021-pol2qm74 6139 49 to to IN cord-015021-pol2qm74 6139 50 the the DT cord-015021-pol2qm74 6139 51 patient patient NN cord-015021-pol2qm74 6139 52 's 's POS cord-015021-pol2qm74 6139 53 severity severity NN cord-015021-pol2qm74 6139 54 end end VB cord-015021-pol2qm74 6139 55 risk risk NN cord-015021-pol2qm74 6139 56 of of IN cord-015021-pol2qm74 6139 57 mortality mortality NN cord-015021-pol2qm74 6139 58 at at IN cord-015021-pol2qm74 6139 59 entry entry NN cord-015021-pol2qm74 6139 60 to to IN cord-015021-pol2qm74 6139 61 the the DT cord-015021-pol2qm74 6139 62 study study NN cord-015021-pol2qm74 6139 63 . . . cord-015021-pol2qm74 6140 1 We -PRON- PRP cord-015021-pol2qm74 6140 2 recently recently RB cord-015021-pol2qm74 6140 3 reported report VBD cord-015021-pol2qm74 6140 4 ( ( -LRB- cord-015021-pol2qm74 6140 5 JAMA JAMA NNP cord-015021-pol2qm74 6140 6 1993;270:1Z33 1993;270:1z33 CD cord-015021-pol2qm74 6140 7 - - HYPH cord-015021-pol2qm74 6140 8 1~41 1~41 CD cord-015021-pol2qm74 6140 9 ) ) -RRB- cord-015021-pol2qm74 6140 10 a a DT cord-015021-pol2qm74 6140 11 comprehensive comprehensive JJ cord-015021-pol2qm74 6140 12 risk risk NN cord-015021-pol2qm74 6140 13 assessment assessment NN cord-015021-pol2qm74 6140 14 approach approach NN cord-015021-pol2qm74 6140 15 for for IN cord-015021-pol2qm74 6140 16 patients patient NNS cord-015021-pol2qm74 6140 17 with with IN cord-015021-pol2qm74 6140 18 sepsis sepsis NN cord-015021-pol2qm74 6140 19 syndrome syndrome NN cord-015021-pol2qm74 6140 20 , , , cord-015021-pol2qm74 6140 21 a a DT cord-015021-pol2qm74 6140 22 common common JJ cord-015021-pol2qm74 6140 23 eategarlcal eategarlcal JJ cord-015021-pol2qm74 6140 24 description description NN cord-015021-pol2qm74 6140 25 used use VBN cord-015021-pol2qm74 6140 26 as as IN cord-015021-pol2qm74 6140 27 an an DT cord-015021-pol2qm74 6140 28 entry entry NN cord-015021-pol2qm74 6140 29 eriterlon eriterlon NN cord-015021-pol2qm74 6140 30 for for IN cord-015021-pol2qm74 6140 31 many many JJ cord-015021-pol2qm74 6140 32 trials trial NNS cord-015021-pol2qm74 6140 33 . . . cord-015021-pol2qm74 6141 1 By by IN cord-015021-pol2qm74 6141 2 screening screen VBG cord-015021-pol2qm74 6141 3 s s POS cord-015021-pol2qm74 6141 4 database database NN cord-015021-pol2qm74 6141 5 of of IN cord-015021-pol2qm74 6141 6 58,737 58,737 CD cord-015021-pol2qm74 6141 7 recent recent JJ cord-015021-pol2qm74 6141 8 admissions admission NNS cord-015021-pol2qm74 6141 9 to to IN cord-015021-pol2qm74 6141 10 107 107 CD cord-015021-pol2qm74 6141 11 hospitals hospital NNS cord-015021-pol2qm74 6141 12 in in IN cord-015021-pol2qm74 6141 13 the the DT cord-015021-pol2qm74 6141 14 United United NNP cord-015021-pol2qm74 6141 15 States States NNP cord-015021-pol2qm74 6141 16 and and CC cord-015021-pol2qm74 6141 17 Western Western NNP cord-015021-pol2qm74 6141 18 Europe Europe NNP cord-015021-pol2qm74 6141 19 , , , cord-015021-pol2qm74 6141 20 we -PRON- PRP cord-015021-pol2qm74 6141 21 identified identify VBD cord-015021-pol2qm74 6141 22 1,195 1,195 CD cord-015021-pol2qm74 6141 23 patients patient NNS cord-015021-pol2qm74 6141 24 who who WP cord-015021-pol2qm74 6141 25 met meet VBD cord-015021-pol2qm74 6141 26 sepsis sepsis NN cord-015021-pol2qm74 6141 27 syndrome syndrome NN cord-015021-pol2qm74 6141 28 criteria criterion NNS cord-015021-pol2qm74 6141 29 but but CC cord-015021-pol2qm74 6141 30 were be VBD cord-015021-pol2qm74 6141 31 not not RB cord-015021-pol2qm74 6141 32 enrolled enrol VBN cord-015021-pol2qm74 6141 33 tn tn NNP cord-015021-pol2qm74 6141 34 clinical clinical JJ cord-015021-pol2qm74 6141 35 trinh trinh NNP cord-015021-pol2qm74 6141 36 , , , cord-015021-pol2qm74 6141 37 We -PRON- PRP cord-015021-pol2qm74 6141 38 then then RB cord-015021-pol2qm74 6141 39 developed develop VBD cord-015021-pol2qm74 6141 40 a a DT cord-015021-pol2qm74 6141 41 survival survival NN cord-015021-pol2qm74 6141 42 model model NN cord-015021-pol2qm74 6141 43 end end NN cord-015021-pol2qm74 6141 44 severlty severlty NN cord-015021-pol2qm74 6141 45 assessment assessment NN cord-015021-pol2qm74 6141 46 method method NN cord-015021-pol2qm74 6141 47 to to TO cord-015021-pol2qm74 6141 48 estimate estimate VB cord-015021-pol2qm74 6141 49 their -PRON- PRP$ cord-015021-pol2qm74 6141 50 2g.day 2g.day CD cord-015021-pol2qm74 6141 51 mortality mortality NN cord-015021-pol2qm74 6141 52 risk risk NN cord-015021-pol2qm74 6141 53 . . . cord-015021-pol2qm74 6142 1 k k NNP cord-015021-pol2qm74 6142 2 .. .. . cord-015021-pol2qm74 6143 1 ente ente NNP cord-015021-pol2qm74 6143 2 physiologic physiologic JJ cord-015021-pol2qm74 6143 3 abnormalities abnormality NNS cord-015021-pol2qm74 6143 4 were be VBD cord-015021-pol2qm74 6143 5 the the DT cord-015021-pol2qm74 6143 6 most most RBS cord-015021-pol2qm74 6143 7 important important JJ cord-015021-pol2qm74 6143 8 prognostic prognostic JJ cord-015021-pol2qm74 6143 9 factors factor NNS cord-015021-pol2qm74 6143 10 ( ( -LRB- cord-015021-pol2qm74 6143 11 82 82 CD cord-015021-pol2qm74 6143 12 % % NN cord-015021-pol2qm74 6143 13 of of IN cord-015021-pol2qm74 6143 14 total total JJ cord-015021-pol2qm74 6143 15 chl chl NNP cord-015021-pol2qm74 6143 16 square square NNP cord-015021-pol2qm74 6143 17 ) ) -RRB- cord-015021-pol2qm74 6143 18 influencing influence VBG cord-015021-pol2qm74 6143 19 outcome outcome NN cord-015021-pol2qm74 6143 20 . . . cord-015021-pol2qm74 6144 1 The the DT cord-015021-pol2qm74 6144 2 specific specific JJ cord-015021-pol2qm74 6144 3 disease disease NN cord-015021-pol2qm74 6144 4 resulting result VBG cord-015021-pol2qm74 6144 5 in in IN cord-015021-pol2qm74 6144 6 Ice Ice NNP cord-015021-pol2qm74 6144 7 admission admission NN cord-015021-pol2qm74 6144 8 and and CC cord-015021-pol2qm74 6144 9 the the DT cord-015021-pol2qm74 6144 10 days day NNS cord-015021-pol2qm74 6144 11 the the DT cord-015021-pol2qm74 6144 12 patient patient NN cord-015021-pol2qm74 6144 13 spent spend VBN cord-015021-pol2qm74 6144 14 In in IN cord-015021-pol2qm74 6144 15 the the DT cord-015021-pol2qm74 6144 16 hospital hospital NN cord-015021-pol2qm74 6144 17 and and CC cord-015021-pol2qm74 6144 18 ICU ICU NNP cord-015021-pol2qm74 6144 19 before before IN cord-015021-pol2qm74 6144 20 qualification qualification NN cord-015021-pol2qm74 6144 21 were be VBD cord-015021-pol2qm74 6144 22 independent independent JJ cord-015021-pol2qm74 6144 23 risks risk NNS cord-015021-pol2qm74 6144 24 , , , cord-015021-pol2qm74 6144 25 as as IN cord-015021-pol2qm74 6144 26 were be VBD cord-015021-pol2qm74 6144 27 age age NN cord-015021-pol2qm74 6144 28 and and CC cord-015021-pol2qm74 6144 29 a a DT cord-015021-pol2qm74 6144 30 clinical clinical JJ cord-015021-pol2qm74 6144 31 history history NN cord-015021-pol2qm74 6144 32 of of IN cord-015021-pol2qm74 6144 33 cirrhosis cirrhosis NN cord-015021-pol2qm74 6144 34 . . . cord-015021-pol2qm74 6145 1 The the DT cord-015021-pol2qm74 6145 2 predictive predictive JJ cord-015021-pol2qm74 6145 3 model model NN cord-015021-pol2qm74 6145 4 was be VBD cord-015021-pol2qm74 6145 5 cross cross JJ cord-015021-pol2qm74 6145 6 - - VBN cord-015021-pol2qm74 6145 7 validated validate VBN cord-015021-pol2qm74 6145 8 within within IN cord-015021-pol2qm74 6145 9 the the DT cord-015021-pol2qm74 6145 10 original original JJ cord-015021-pol2qm74 6145 11 1,195 1,195 CD cord-015021-pol2qm74 6145 12 patients patient NNS cord-015021-pol2qm74 6145 13 with with IN cord-015021-pol2qm74 6145 14 a a DT cord-015021-pol2qm74 6145 15 Receiver Receiver NNP cord-015021-pol2qm74 6145 16 D_perator D_perator NNP cord-015021-pol2qm74 6145 17 Characteristics Characteristics NNP cord-015021-pol2qm74 6145 18 ( ( -LRB- cord-015021-pol2qm74 6145 19 ROC ROC NNP cord-015021-pol2qm74 6145 20 ) ) -RRB- cord-015021-pol2qm74 6145 21 area area NN cord-015021-pol2qm74 6145 22 of of IN cord-015021-pol2qm74 6145 23 0.76 0.76 CD cord-015021-pol2qm74 6145 24 and and CC cord-015021-pol2qm74 6146 1 In in IN cord-015021-pol2qm74 6146 2 two two CD cord-015021-pol2qm74 6146 3 Independent independent JJ cord-015021-pol2qm74 6146 4 databases database NNS cord-015021-pol2qm74 6146 5 , , , cord-015021-pol2qm74 6146 6 The the DT cord-015021-pol2qm74 6146 7 first first JJ cord-015021-pol2qm74 6146 8 independent independent JJ cord-015021-pol2qm74 6146 9 database database NN cord-015021-pol2qm74 6146 10 contained contain VBD cord-015021-pol2qm74 6146 11 295 295 CD cord-015021-pol2qm74 6146 12 hospitalized hospitalize VBN cord-015021-pol2qm74 6146 13 patients patient NNS cord-015021-pol2qm74 6146 14 with with IN cord-015021-pol2qm74 6146 15 gram gram JJ cord-015021-pol2qm74 6146 16 - - HYPH cord-015021-pol2qm74 6146 17 negative negative JJ cord-015021-pol2qm74 6146 18 infection infection NN cord-015021-pol2qm74 6146 19 meeting meeting NN cord-015021-pol2qm74 6146 20 criteria criterion NNS cord-015021-pol2qm74 6146 21 for for IN cord-015021-pol2qm74 6146 22 sepsis sepsis NN cord-015021-pol2qm74 6146 23 syndrome syndrome NN cord-015021-pol2qm74 6146 24 ( ( -LRB- cord-015021-pol2qm74 6146 25 ROC=0.80 ROC=0.80 NNP cord-015021-pol2qm74 6146 26 ) ) -RRB- cord-015021-pol2qm74 6146 27 ; ; : cord-015021-pol2qm74 6146 28 in in IN cord-015021-pol2qm74 6146 29 the the DT cord-015021-pol2qm74 6146 30 second second JJ cord-015021-pol2qm74 6146 31 , , , cord-015021-pol2qm74 6146 32 the the DT cord-015021-pol2qm74 6146 33 302 302 CD cord-015021-pol2qm74 6146 34 placebo placebo NN cord-015021-pol2qm74 6146 35 patients patient NNS cord-015021-pol2qm74 6146 36 withtn withtn NNP cord-015021-pol2qm74 6146 37 the the DT cord-015021-pol2qm74 6146 38 recently recently RB cord-015021-pol2qm74 6146 39 completed complete VBN cord-015021-pol2qm74 6146 40 Phase phase NN cord-015021-pol2qm74 6146 41 Ill Ill NNP cord-015021-pol2qm74 6146 42 e e NN cord-015021-pol2qm74 6147 1 ~aluatlan ~aluatlan NNP cord-015021-pol2qm74 6147 2 of of IN cord-015021-pol2qm74 6147 3 IL-1Ra IL-1Ra NNP cord-015021-pol2qm74 6147 4 ( ( -LRB- cord-015021-pol2qm74 6147 5 ROCffi0.76 ROCffi0.76 NNP cord-015021-pol2qm74 6147 6 ) ) -RRB- cord-015021-pol2qm74 6147 7 . . . cord-015021-pol2qm74 6148 1 In in IN cord-015021-pol2qm74 6148 2 all all DT cord-015021-pol2qm74 6148 3 databases database NNS cord-015021-pol2qm74 6148 4 the the DT cord-015021-pol2qm74 6148 5 risk risk NN cord-015021-pol2qm74 6148 6 model model NN cord-015021-pol2qm74 6148 7 was be VBD cord-015021-pol2qm74 6148 8 able able JJ cord-015021-pol2qm74 6148 9 to to TO cord-015021-pol2qm74 6148 10 accurately accurately RB cord-015021-pol2qm74 6148 11 risk risk VB cord-015021-pol2qm74 6148 12 stratify stratify VB cord-015021-pol2qm74 6148 13 patients patient NNS cord-015021-pol2qm74 6148 14 throughout throughout IN cord-015021-pol2qm74 6148 15 the the DT cord-015021-pol2qm74 6148 16 range range NN cord-015021-pol2qm74 6148 17 of of IN cord-015021-pol2qm74 6148 18 risks risk NNS cord-015021-pol2qm74 6148 19 that that WDT cord-015021-pol2qm74 6148 20 varled varle VBD cord-015021-pol2qm74 6148 21 from from IN cord-015021-pol2qm74 6148 22 a a DT cord-015021-pol2qm74 6148 23 very very RB cord-015021-pol2qm74 6148 24 low low JJ cord-015021-pol2qm74 6148 25 1 1 CD cord-015021-pol2qm74 6148 26 % % NN cord-015021-pol2qm74 6148 27 to to IN cord-015021-pol2qm74 6148 28 a a DT cord-015021-pol2qm74 6148 29 very very JJ cord-015021-pol2qm74 6148 30 hlglt hlglt NNP cord-015021-pol2qm74 6148 31 99 99 CD cord-015021-pol2qm74 6148 32 % % NN cord-015021-pol2qm74 6148 33 . . . cord-015021-pol2qm74 6149 1 By by IN cord-015021-pol2qm74 6149 2 drawing draw VBG cord-015021-pol2qm74 6149 3 on on IN cord-015021-pol2qm74 6149 4 the the DT cord-015021-pol2qm74 6149 5 ready ready JJ cord-015021-pol2qm74 6149 6 avatlabillty avatlabillty NN cord-015021-pol2qm74 6149 7 of of IN cord-015021-pol2qm74 6149 8 large large JJ cord-015021-pol2qm74 6149 9 clinically clinically RB cord-015021-pol2qm74 6149 10 aeuurate aeuurate NN cord-015021-pol2qm74 6149 11 , , , cord-015021-pol2qm74 6149 12 current current JJ cord-015021-pol2qm74 6149 13 databases database NNS cord-015021-pol2qm74 6149 14 and and CC cord-015021-pol2qm74 6149 15 using use VBG cord-015021-pol2qm74 6149 16 the the DT cord-015021-pol2qm74 6149 17 power power NN cord-015021-pol2qm74 6149 18 of of IN cord-015021-pol2qm74 6149 19 modern modern JJ cord-015021-pol2qm74 6149 20 statistical statistical JJ cord-015021-pol2qm74 6149 21 techniques technique NNS cord-015021-pol2qm74 6149 22 to to TO cord-015021-pol2qm74 6149 23 model model VB cord-015021-pol2qm74 6149 24 the the DT cord-015021-pol2qm74 6149 25 bodfs bodfs NNP cord-015021-pol2qm74 6149 26 response response NN cord-015021-pol2qm74 6149 27 to to IN cord-015021-pol2qm74 6149 28 sepsis sepsis NN cord-015021-pol2qm74 6149 29 , , , cord-015021-pol2qm74 6149 30 we -PRON- PRP cord-015021-pol2qm74 6149 31 are be VBP cord-015021-pol2qm74 6149 32 able able JJ cord-015021-pol2qm74 6149 33 to to TO cord-015021-pol2qm74 6149 34 produce produce VB cord-015021-pol2qm74 6149 35 very very RB cord-015021-pol2qm74 6149 36 aeettrate aeettrate JJ cord-015021-pol2qm74 6149 37 pre pre JJ cord-015021-pol2qm74 6149 38 - - JJ cord-015021-pol2qm74 6149 39 treatment treatment JJ cord-015021-pol2qm74 6149 40 risk risk NN cord-015021-pol2qm74 6149 41 estimates estimate NNS cord-015021-pol2qm74 6149 42 , , , cord-015021-pol2qm74 6149 43 These these DT cord-015021-pol2qm74 6149 44 prospectively prospectively RB cord-015021-pol2qm74 6149 45 defined define VBN cord-015021-pol2qm74 6149 46 and and CC cord-015021-pol2qm74 6149 47 continuous continuous JJ cord-015021-pol2qm74 6149 48 risk risk NN cord-015021-pol2qm74 6149 49 estimates estimate NNS cord-015021-pol2qm74 6149 50 reduce reduce VBP cord-015021-pol2qm74 6149 51 reliance reliance NN cord-015021-pol2qm74 6149 52 on on IN cord-015021-pol2qm74 6149 53 multiple multiple JJ cord-015021-pol2qm74 6149 54 subgroups subgroup NNS cord-015021-pol2qm74 6149 55 and and CC cord-015021-pol2qm74 6149 56 data datum NNS cord-015021-pol2qm74 6149 57 dredging dredging NN cord-015021-pol2qm74 6149 58 that that WDT cord-015021-pol2qm74 6149 59 can can MD cord-015021-pol2qm74 6149 60 compromise compromise VB cord-015021-pol2qm74 6149 61 a a DT cord-015021-pol2qm74 6149 62 stady stady NNP cord-015021-pol2qm74 6149 63 's 's POS cord-015021-pol2qm74 6149 64 integrity integrity NN cord-015021-pol2qm74 6149 65 . . . cord-015021-pol2qm74 6150 1 They -PRON- PRP cord-015021-pol2qm74 6150 2 cart cart VBP cord-015021-pol2qm74 6150 3 provide provide VBP cord-015021-pol2qm74 6150 4 a a DT cord-015021-pol2qm74 6150 5 nnlform nnlform NN cord-015021-pol2qm74 6150 6 method method NN cord-015021-pol2qm74 6150 7 for for IN cord-015021-pol2qm74 6150 8 patient patient JJ cord-015021-pol2qm74 6150 9 description description NN cord-015021-pol2qm74 6150 10 across across IN cord-015021-pol2qm74 6150 11 clinical clinical JJ cord-015021-pol2qm74 6150 12 trials trial NNS cord-015021-pol2qm74 6150 13 of of IN cord-015021-pol2qm74 6150 14 different different JJ cord-015021-pol2qm74 6150 15 attempts attempt NNS cord-015021-pol2qm74 6150 16 at at IN cord-015021-pol2qm74 6150 17 immmlotherapy immmlotherapy NNP cord-015021-pol2qm74 6150 18 . . . cord-015021-pol2qm74 6151 1 Risk risk NN cord-015021-pol2qm74 6151 2 calculations calculation NNS cord-015021-pol2qm74 6151 3 can can MD cord-015021-pol2qm74 6151 4 also also RB cord-015021-pol2qm74 6151 5 be be VB cord-015021-pol2qm74 6151 6 useful useful JJ cord-015021-pol2qm74 6151 7 in in IN cord-015021-pol2qm74 6151 8 developing develop VBG cord-015021-pol2qm74 6151 9 entry entry NN cord-015021-pol2qm74 6151 10 criteria criterion NNS cord-015021-pol2qm74 6151 11 for for IN cord-015021-pol2qm74 6151 12 Phase Phase NNP cord-015021-pol2qm74 6151 13 II II NNP cord-015021-pol2qm74 6151 14 evaluations evaluation NNS cord-015021-pol2qm74 6151 15 in in IN cord-015021-pol2qm74 6151 16 order order NN cord-015021-pol2qm74 6151 17 to to TO cord-015021-pol2qm74 6151 18 initially initially RB cord-015021-pol2qm74 6151 19 test test VB cord-015021-pol2qm74 6151 20 efficacy efficacy NN cord-015021-pol2qm74 6151 21 on on IN cord-015021-pol2qm74 6151 22 a a DT cord-015021-pol2qm74 6151 23 limited limited JJ cord-015021-pol2qm74 6151 24 number number NN cord-015021-pol2qm74 6151 25 of of IN cord-015021-pol2qm74 6151 26 high high JJ cord-015021-pol2qm74 6151 27 risk risk NN cord-015021-pol2qm74 6151 28 patients patient NNS cord-015021-pol2qm74 6151 29 , , , cord-015021-pol2qm74 6151 30 Fonowing Fonowing NNP cord-015021-pol2qm74 6151 31 sueeessinl sueeessinl NNS cord-015021-pol2qm74 6151 32 completion completion NN cord-015021-pol2qm74 6151 33 of of IN cord-015021-pol2qm74 6151 34 a a DT cord-015021-pol2qm74 6151 35 definitive definitive JJ cord-015021-pol2qm74 6151 36 trial trial NN cord-015021-pol2qm74 6151 37 , , , cord-015021-pol2qm74 6151 38 the the DT cord-015021-pol2qm74 6151 39 risk risk NN cord-015021-pol2qm74 6151 40 estimates estimate NNS cord-015021-pol2qm74 6151 41 can can MD cord-015021-pol2qm74 6151 42 be be VB cord-015021-pol2qm74 6151 43 used use VBN cord-015021-pol2qm74 6151 44 to to TO cord-015021-pol2qm74 6151 45 develop develop VB cord-015021-pol2qm74 6151 46 specific specific JJ cord-015021-pol2qm74 6151 47 |ndlcattons |ndlcatton NNS cord-015021-pol2qm74 6151 48 for for IN cord-015021-pol2qm74 6151 49 s s NNP cord-015021-pol2qm74 6151 50 drug drug NN cord-015021-pol2qm74 6151 51 's 's POS cord-015021-pol2qm74 6151 52 use use NN cord-015021-pol2qm74 6151 53 and and CC cord-015021-pol2qm74 6151 54 can can MD cord-015021-pol2qm74 6151 55 monitor monitor VB cord-015021-pol2qm74 6151 56 the the DT cord-015021-pol2qm74 6151 57 impact impact NN cord-015021-pol2qm74 6151 58 of of IN cord-015021-pol2qm74 6151 59 both both CC cord-015021-pol2qm74 6151 60 new new JJ cord-015021-pol2qm74 6151 61 and and CC cord-015021-pol2qm74 6151 62 multiple multiple JJ cord-015021-pol2qm74 6151 63 compounds compound NNS cord-015021-pol2qm74 6151 64 on on IN cord-015021-pol2qm74 6151 65 patient patient NN cord-015021-pol2qm74 6151 66 outrome outrome NN cord-015021-pol2qm74 6151 67 , , , cord-015021-pol2qm74 6151 68 When when WRB cord-015021-pol2qm74 6151 69 dealing deal VBG cord-015021-pol2qm74 6151 70 with with IN cord-015021-pol2qm74 6151 71 therapeutic therapeutic JJ cord-015021-pol2qm74 6151 72 trials trial NNS cord-015021-pol2qm74 6151 73 for for IN cord-015021-pol2qm74 6151 74 the the DT cord-015021-pol2qm74 6151 75 treatment treatment NN cord-015021-pol2qm74 6151 76 of of IN cord-015021-pol2qm74 6151 77 sepsis sepsis NN cord-015021-pol2qm74 6151 78 , , , cord-015021-pol2qm74 6151 79 there there EX cord-015021-pol2qm74 6151 80 are be VBP cord-015021-pol2qm74 6151 81 2 2 CD cord-015021-pol2qm74 6151 82 ways way NNS cord-015021-pol2qm74 6151 83 of of IN cord-015021-pol2qm74 6151 84 checking check VBG cord-015021-pol2qm74 6151 85 the the DT cord-015021-pol2qm74 6151 86 comparability comparability NN cord-015021-pol2qm74 6151 87 of of IN cord-015021-pol2qm74 6151 88 the the DT cord-015021-pol2qm74 6151 89 groups group NNS cord-015021-pol2qm74 6151 90 ( ( -LRB- cord-015021-pol2qm74 6151 91 placebo placebo NN cord-015021-pol2qm74 6151 92 and and CC cord-015021-pol2qm74 6151 93 treated treat VBN cord-015021-pol2qm74 6151 94 groups group NNS cord-015021-pol2qm74 6151 95 ) ) -RRB- cord-015021-pol2qm74 6152 1 -To -To : cord-015021-pol2qm74 6152 2 use use VB cord-015021-pol2qm74 6152 3 several several JJ cord-015021-pol2qm74 6152 4 description description NN cord-015021-pol2qm74 6152 5 items item NNS cord-015021-pol2qm74 6152 6 such such JJ cord-015021-pol2qm74 6152 7 as as IN cord-015021-pol2qm74 6152 8 age age NN cord-015021-pol2qm74 6152 9 , , , cord-015021-pol2qm74 6152 10 sex sex NN cord-015021-pol2qm74 6152 11 , , , cord-015021-pol2qm74 6152 12 preexisting preexist VBG cord-015021-pol2qm74 6152 13 disease disease NN cord-015021-pol2qm74 6152 14 , , , cord-015021-pol2qm74 6152 15 number number NN cord-015021-pol2qm74 6152 16 and and CC cord-015021-pol2qm74 6152 17 nature nature NN cord-015021-pol2qm74 6152 18 of of IN cord-015021-pol2qm74 6152 19 organ organ NN cord-015021-pol2qm74 6152 20 failures failure NNS cord-015021-pol2qm74 6152 21 , , , cord-015021-pol2qm74 6152 22 physiology physiology NN cord-015021-pol2qm74 6152 23 score score NN cord-015021-pol2qm74 6152 24 , , , cord-015021-pol2qm74 6152 25 such such JJ cord-015021-pol2qm74 6152 26 as as IN cord-015021-pol2qm74 6152 27 SAPS SAPS NNP cord-015021-pol2qm74 6152 28 IL IL NNP cord-015021-pol2qm74 6152 29 ( ( -LRB- cord-015021-pol2qm74 6152 30 1 1 CD cord-015021-pol2qm74 6152 31 ) ) -RRB- cord-015021-pol2qm74 6152 32 -To -To : cord-015021-pol2qm74 6152 33 use use VBP cord-015021-pol2qm74 6152 34 a a DT cord-015021-pol2qm74 6152 35 model model NN cord-015021-pol2qm74 6152 36 for for IN cord-015021-pol2qm74 6152 37 risk risk NN cord-015021-pol2qm74 6152 38 of of IN cord-015021-pol2qm74 6152 39 death death NN cord-015021-pol2qm74 6152 40 either either CC cord-015021-pol2qm74 6152 41 from from IN cord-015021-pol2qm74 6152 42 a a DT cord-015021-pol2qm74 6152 43 score score NN cord-015021-pol2qm74 6152 44 ( ( -LRB- cord-015021-pol2qm74 6152 45 APACHE APACHE NNP cord-015021-pol2qm74 6152 46 II II NNP cord-015021-pol2qm74 6152 47 , , , cord-015021-pol2qm74 6152 48 lII lII NNP cord-015021-pol2qm74 6152 49 , , , cord-015021-pol2qm74 6152 50 ( ( -LRB- cord-015021-pol2qm74 6152 51 2 2 LS cord-015021-pol2qm74 6152 52 ) ) -RRB- cord-015021-pol2qm74 6152 53 SAPS SAPS NNP cord-015021-pol2qm74 6152 54 II II NNP cord-015021-pol2qm74 6152 55 ) ) -RRB- cord-015021-pol2qm74 6152 56 or or CC cord-015021-pol2qm74 6152 57 directly directly RB cord-015021-pol2qm74 6152 58 ( ( -LRB- cord-015021-pol2qm74 6152 59 MPM MPM NNP cord-015021-pol2qm74 6152 60 II II NNP cord-015021-pol2qm74 6152 61 system system NN cord-015021-pol2qm74 6152 62 ( ( -LRB- cord-015021-pol2qm74 6152 63 3 3 CD cord-015021-pol2qm74 6152 64 ) ) -RRB- cord-015021-pol2qm74 6152 65 ) ) -RRB- cord-015021-pol2qm74 6153 1 Before before IN cord-015021-pol2qm74 6153 2 using use VBG cord-015021-pol2qm74 6153 3 the the DT cord-015021-pol2qm74 6153 4 model model NN cord-015021-pol2qm74 6153 5 for for IN cord-015021-pol2qm74 6153 6 risk risk NN cord-015021-pol2qm74 6153 7 of of IN cord-015021-pol2qm74 6153 8 death death NN cord-015021-pol2qm74 6153 9 in in IN cord-015021-pol2qm74 6153 10 septic septic JJ cord-015021-pol2qm74 6153 11 patients patient NNS cord-015021-pol2qm74 6153 12 , , , cord-015021-pol2qm74 6153 13 is be VBZ cord-015021-pol2qm74 6153 14 it -PRON- PRP cord-015021-pol2qm74 6153 15 mandatory mandatory JJ cord-015021-pol2qm74 6153 16 to to TO cord-015021-pol2qm74 6153 17 validate validate VB cord-015021-pol2qm74 6153 18 it -PRON- PRP cord-015021-pol2qm74 6153 19 ( ( -LRB- cord-015021-pol2qm74 6153 20 by by IN cord-015021-pol2qm74 6153 21 calibration calibration NN cord-015021-pol2qm74 6153 22 , , , cord-015021-pol2qm74 6153 23 i.e. i.e. FW cord-015021-pol2qm74 6153 24 goodness goodness NN cord-015021-pol2qm74 6153 25 of of IN cord-015021-pol2qm74 6153 26 fit fit NN cord-015021-pol2qm74 6153 27 , , , cord-015021-pol2qm74 6153 28 and and CC cord-015021-pol2qm74 6153 29 discrin'dnation discrin'dnation NNP cord-015021-pol2qm74 6153 30 , , , cord-015021-pol2qm74 6153 31 i.e. i.e. FW cord-015021-pol2qm74 6153 32 , , , cord-015021-pol2qm74 6153 33 ROC ROC NNP cord-015021-pol2qm74 6153 34 curves curve VBZ cord-015021-pol2qm74 6153 35 ) ) -RRB- cord-015021-pol2qm74 6153 36 first first RB cord-015021-pol2qm74 6153 37 on on IN cord-015021-pol2qm74 6153 38 a a DT cord-015021-pol2qm74 6153 39 data data NN cord-015021-pol2qm74 6153 40 base base NN cord-015021-pol2qm74 6153 41 using use VBG cord-015021-pol2qm74 6153 42 the the DT cord-015021-pol2qm74 6153 43 same same JJ cord-015021-pol2qm74 6153 44 definition definition NN cord-015021-pol2qm74 6153 45 for for IN cord-015021-pol2qm74 6153 46 sepsis sepsis NN cord-015021-pol2qm74 6153 47 as as IN cord-015021-pol2qm74 6153 48 in in IN cord-015021-pol2qm74 6153 49 the the DT cord-015021-pol2qm74 6153 50 trial trial NN cord-015021-pol2qm74 6153 51 and and CC cord-015021-pol2qm74 6153 52 secondly secondly RB cord-015021-pol2qm74 6153 53 on on IN cord-015021-pol2qm74 6153 54 the the DT cord-015021-pol2qm74 6153 55 placebo placebo NN cord-015021-pol2qm74 6153 56 group group NN cord-015021-pol2qm74 6153 57 of of IN cord-015021-pol2qm74 6153 58 the the DT cord-015021-pol2qm74 6153 59 trial trial NN cord-015021-pol2qm74 6153 60 ? ? . cord-015021-pol2qm74 6154 1 or or CC cord-015021-pol2qm74 6154 2 is be VBZ cord-015021-pol2qm74 6154 3 it -PRON- PRP cord-015021-pol2qm74 6154 4 better well JJR cord-015021-pol2qm74 6154 5 to to TO cord-015021-pol2qm74 6154 6 use use VB cord-015021-pol2qm74 6154 7 a a DT cord-015021-pol2qm74 6154 8 specific specific JJ cord-015021-pol2qm74 6154 9 model model NN cord-015021-pol2qm74 6154 10 for for IN cord-015021-pol2qm74 6154 11 each each DT cord-015021-pol2qm74 6154 12 trial trial NN cord-015021-pol2qm74 6154 13 ? ? . cord-015021-pol2qm74 6155 1 The the DT cord-015021-pol2qm74 6155 2 general general JJ cord-015021-pol2qm74 6155 3 models model NNS cord-015021-pol2qm74 6155 4 usually usually RB cord-015021-pol2qm74 6155 5 do do VBP cord-015021-pol2qm74 6155 6 uot uot VBN cord-015021-pol2qm74 6155 7 fit fit VB cord-015021-pol2qm74 6155 8 for for IN cord-015021-pol2qm74 6155 9 septic septic JJ cord-015021-pol2qm74 6155 10 patients patient NNS cord-015021-pol2qm74 6155 11 . . . cord-015021-pol2qm74 6156 1 There there EX cord-015021-pol2qm74 6156 2 are be VBP cord-015021-pol2qm74 6156 3 2 2 CD cord-015021-pol2qm74 6156 4 methods method NNS cord-015021-pol2qm74 6156 5 to to TO cord-015021-pol2qm74 6156 6 make make VB cord-015021-pol2qm74 6156 7 them -PRON- PRP cord-015021-pol2qm74 6156 8 fit fit JJ cord-015021-pol2qm74 6156 9 : : : cord-015021-pol2qm74 6156 10 either either CC cord-015021-pol2qm74 6156 11 to to TO cord-015021-pol2qm74 6156 12 add add VB cord-015021-pol2qm74 6156 13 variables variable NNS cord-015021-pol2qm74 6156 14 to to IN cord-015021-pol2qm74 6156 15 the the DT cord-015021-pol2qm74 6156 16 original original JJ cord-015021-pol2qm74 6156 17 score score NN cord-015021-pol2qm74 6156 18 ( ( -LRB- cord-015021-pol2qm74 6156 19 model model NN cord-015021-pol2qm74 6156 20 for for IN cord-015021-pol2qm74 6156 21 sepsis sepsis NN cord-015021-pol2qm74 6156 22 using use VBG cord-015021-pol2qm74 6156 23 the the DT cord-015021-pol2qm74 6156 24 APACHE APACHE NNP cord-015021-pol2qm74 6156 25 III III NNP cord-015021-pol2qm74 6156 26 system system NN cord-015021-pol2qm74 6156 27 ( ( -LRB- cord-015021-pol2qm74 6156 28 4 4 CD cord-015021-pol2qm74 6156 29 ) ) -RRB- cord-015021-pol2qm74 6156 30 ) ) -RRB- cord-015021-pol2qm74 6156 31 or or CC cord-015021-pol2qm74 6156 32 to to TO cord-015021-pol2qm74 6156 33 customize customize VB cord-015021-pol2qm74 6156 34 the the DT cord-015021-pol2qm74 6156 35 model model NN cord-015021-pol2qm74 6156 36 . . . cord-015021-pol2qm74 6157 1 For for IN cord-015021-pol2qm74 6157 2 SAPS SAPS NNP cord-015021-pol2qm74 6157 3 II II NNP cord-015021-pol2qm74 6157 4 the the DT cord-015021-pol2qm74 6157 5 customization customization NN cord-015021-pol2qm74 6157 6 is be VBZ cord-015021-pol2qm74 6157 7 applied apply VBN cord-015021-pol2qm74 6157 8 to to IN cord-015021-pol2qm74 6157 9 the the DT cord-015021-pol2qm74 6157 10 equation equation NN cord-015021-pol2qm74 6157 11 regression regression NN cord-015021-pol2qm74 6157 12 , , , cord-015021-pol2qm74 6157 13 using use VBG cord-015021-pol2qm74 6157 14 the the DT cord-015021-pol2qm74 6157 15 same same JJ cord-015021-pol2qm74 6157 16 SAPS SAPS NNP cord-015021-pol2qm74 6157 17 II II NNP cord-015021-pol2qm74 6157 18 score score NN cord-015021-pol2qm74 6157 19 . . . cord-015021-pol2qm74 6158 1 For for IN cord-015021-pol2qm74 6158 2 MPM MPM NNP cord-015021-pol2qm74 6158 3 1I 1i CD cord-015021-pol2qm74 6158 4 each each DT cord-015021-pol2qm74 6158 5 component component NN cord-015021-pol2qm74 6158 6 of of IN cord-015021-pol2qm74 6158 7 the the DT cord-015021-pol2qm74 6158 8 model model NN cord-015021-pol2qm74 6158 9 can can MD cord-015021-pol2qm74 6158 10 be be VB cord-015021-pol2qm74 6158 11 customized customize VBN cord-015021-pol2qm74 6158 12 . . . cord-015021-pol2qm74 6159 1 Several several JJ cord-015021-pol2qm74 6159 2 Remarks remark NNS cord-015021-pol2qm74 6159 3 : : : cord-015021-pol2qm74 6159 4 Only only RB cord-015021-pol2qm74 6159 5 one one CD cord-015021-pol2qm74 6159 6 model model NN cord-015021-pol2qm74 6159 7 is be VBZ cord-015021-pol2qm74 6159 8 published publish VBN cord-015021-pol2qm74 6159 9 to to TO cord-015021-pol2qm74 6159 10 be be VB cord-015021-pol2qm74 6159 11 applied apply VBN cord-015021-pol2qm74 6159 12 at at IN cord-015021-pol2qm74 6159 13 the the DT cord-015021-pol2qm74 6159 14 ICU ICU NNP cord-015021-pol2qm74 6159 15 entry entry NN cord-015021-pol2qm74 6159 16 ( ( -LRB- cord-015021-pol2qm74 6159 17 MPM MPM NNP cord-015021-pol2qm74 6159 18 II II NNP cord-015021-pol2qm74 6159 19 0 0 NFP cord-015021-pol2qm74 6159 20 ) ) -RRB- cord-015021-pol2qm74 6159 21 before before IN cord-015021-pol2qm74 6159 22 any any DT cord-015021-pol2qm74 6159 23 therapy therapy NN cord-015021-pol2qm74 6159 24 . . . cord-015021-pol2qm74 6160 1 2 2 LS cord-015021-pol2qm74 6160 2 -Most -most NN cord-015021-pol2qm74 6160 3 of of IN cord-015021-pol2qm74 6160 4 the the DT cord-015021-pol2qm74 6160 5 published publish VBN cord-015021-pol2qm74 6160 6 scores score NNS cord-015021-pol2qm74 6160 7 are be VBP cord-015021-pol2qm74 6160 8 calculated calculate VBN cord-015021-pol2qm74 6160 9 from from IN cord-015021-pol2qm74 6160 10 the the DT cord-015021-pol2qm74 6160 11 lsl lsl NNP cord-015021-pol2qm74 6160 12 ICU ICU NNP cord-015021-pol2qm74 6160 13 day day NN cord-015021-pol2qm74 6160 14 . . . cord-015021-pol2qm74 6161 1 Applying apply VBG cord-015021-pol2qm74 6161 2 these these DT cord-015021-pol2qm74 6161 3 scores score NNS cord-015021-pol2qm74 6161 4 to to IN cord-015021-pol2qm74 6161 5 the the DT cord-015021-pol2qm74 6161 6 let let JJ cord-015021-pol2qm74 6161 7 day day NN cord-015021-pol2qm74 6161 8 of of IN cord-015021-pol2qm74 6161 9 sepsis sepsis NN cord-015021-pol2qm74 6161 10 could could MD cord-015021-pol2qm74 6161 11 have have VB cord-015021-pol2qm74 6161 12 a a DT cord-015021-pol2qm74 6161 13 very very RB cord-015021-pol2qm74 6161 14 different different JJ cord-015021-pol2qm74 6161 15 significance significance NN cord-015021-pol2qm74 6161 16 . . . cord-015021-pol2qm74 6162 1 3 3 LS cord-015021-pol2qm74 6162 2 -Is -i VBZ cord-015021-pol2qm74 6162 3 the the DT cord-015021-pol2qm74 6162 4 ACCP ACCP NNP cord-015021-pol2qm74 6162 5 classification classification NN cord-015021-pol2qm74 6162 6 of of IN cord-015021-pol2qm74 6162 7 sepsis sepsis NN cord-015021-pol2qm74 6162 8 useful useful JJ cord-015021-pol2qm74 6162 9 at at IN cord-015021-pol2qm74 6162 10 the the DT cord-015021-pol2qm74 6162 11 bedside bedside NN cord-015021-pol2qm74 6162 12 to to TO cord-015021-pol2qm74 6162 13 select select VB cord-015021-pol2qm74 6162 14 oatients oatient NNS cord-015021-pol2qm74 6162 15 ? ? . cord-015021-pol2qm74 6163 1 ( ( -LRB- cord-015021-pol2qm74 6163 2 The the DT cord-015021-pol2qm74 6163 3 pathophysiology pathophysiology NN cord-015021-pol2qm74 6163 4 of of IN cord-015021-pol2qm74 6163 5 sepsis sepsis NN cord-015021-pol2qm74 6163 6 involves involve VBZ cord-015021-pol2qm74 6163 7 a a DT cord-015021-pol2qm74 6163 8 dynamic dynamic JJ cord-015021-pol2qm74 6163 9 interaction interaction NN cord-015021-pol2qm74 6163 10 between between IN cord-015021-pol2qm74 6163 11 the the DT cord-015021-pol2qm74 6163 12 host host NN cord-015021-pol2qm74 6163 13 and and CC cord-015021-pol2qm74 6163 14 the the DT cord-015021-pol2qm74 6163 15 infecting infect VBG cord-015021-pol2qm74 6163 16 microorganism(s microorganism(s NNP cord-015021-pol2qm74 6163 17 ) ) -RRB- cord-015021-pol2qm74 6163 18 . . . cord-015021-pol2qm74 6164 1 A a DT cord-015021-pol2qm74 6164 2 multitude multitude NN cord-015021-pol2qm74 6164 3 of of IN cord-015021-pol2qm74 6164 4 biochemical biochemical JJ cord-015021-pol2qm74 6164 5 and and CC cord-015021-pol2qm74 6164 6 hemodynamic hemodynamic JJ cord-015021-pol2qm74 6164 7 interactions interaction NNS cord-015021-pol2qm74 6164 8 occur occur VBP cord-015021-pol2qm74 6164 9 which which WDT cord-015021-pol2qm74 6164 10 function function VBP cord-015021-pol2qm74 6164 11 in in IN cord-015021-pol2qm74 6164 12 concert concert NN cord-015021-pol2qm74 6164 13 to to TO cord-015021-pol2qm74 6164 14 determine determine VB cord-015021-pol2qm74 6164 15 the the DT cord-015021-pol2qm74 6164 16 ultimate ultimate JJ cord-015021-pol2qm74 6164 17 outcome outcome NN cord-015021-pol2qm74 6164 18 of of IN cord-015021-pol2qm74 6164 19 the the DT cord-015021-pol2qm74 6164 20 septic septic JJ cord-015021-pol2qm74 6164 21 episode episode NN cord-015021-pol2qm74 6164 22 . . . cord-015021-pol2qm74 6165 1 The the DT cord-015021-pol2qm74 6165 2 complexities complexity NNS cord-015021-pol2qm74 6165 3 of of IN cord-015021-pol2qm74 6165 4 the the DT cord-015021-pol2qm74 6165 5 septic septic JJ cord-015021-pol2qm74 6165 6 process process NN cord-015021-pol2qm74 6165 7 preclude preclude VBP cord-015021-pol2qm74 6165 8 outcome outcome NN cord-015021-pol2qm74 6165 9 analysis analysis NN cord-015021-pol2qm74 6165 10 by by IN cord-015021-pol2qm74 6165 11 in in FW cord-015021-pol2qm74 6165 12 vitro vitro FW cord-015021-pol2qm74 6165 13 systems system NNS cord-015021-pol2qm74 6165 14 or or CC cord-015021-pol2qm74 6165 15 computer computer NN cord-015021-pol2qm74 6165 16 models model NNS cord-015021-pol2qm74 6165 17 , , , cord-015021-pol2qm74 6165 18 Animal Animal NNP cord-015021-pol2qm74 6165 19 studies study NNS cord-015021-pol2qm74 6165 20 have have VBP cord-015021-pol2qm74 6165 21 become become VBN cord-015021-pol2qm74 6165 22 indispensable indispensable JJ cord-015021-pol2qm74 6165 23 in in IN cord-015021-pol2qm74 6165 24 evaluating evaluate VBG cord-015021-pol2qm74 6165 25 new new JJ cord-015021-pol2qm74 6165 26 therapeutic therapeutic JJ cord-015021-pol2qm74 6165 27 agents agent NNS cord-015021-pol2qm74 6165 28 in in IN cord-015021-pol2qm74 6165 29 the the DT cord-015021-pol2qm74 6165 30 treatment treatment NN cord-015021-pol2qm74 6165 31 of of IN cord-015021-pol2qm74 6165 32 sepsis sepsis NN cord-015021-pol2qm74 6165 33 . . . cord-015021-pol2qm74 6166 1 These these DT cord-015021-pol2qm74 6166 2 studies study NNS cord-015021-pol2qm74 6166 3 provide provide VBP cord-015021-pol2qm74 6166 4 valuable valuable JJ cord-015021-pol2qm74 6166 5 information information NN cord-015021-pol2qm74 6166 6 on on IN cord-015021-pol2qm74 6166 7 safety safety NN cord-015021-pol2qm74 6166 8 , , , cord-015021-pol2qm74 6166 9 pharmacokinetics pharmacokinetic NNS cord-015021-pol2qm74 6166 10 , , , cord-015021-pol2qm74 6166 11 relative relative JJ cord-015021-pol2qm74 6166 12 efficacy efficacy NN cord-015021-pol2qm74 6166 13 and and CC cord-015021-pol2qm74 6166 14 dosing dose VBG cord-015021-pol2qm74 6166 15 strategies strategy NNS cord-015021-pol2qm74 6166 16 for for IN cord-015021-pol2qm74 6166 17 potential potential JJ cord-015021-pol2qm74 6166 18 therapeutic therapeutic JJ cord-015021-pol2qm74 6166 19 agents agent NNS cord-015021-pol2qm74 6166 20 in in IN cord-015021-pol2qm74 6166 21 the the DT cord-015021-pol2qm74 6166 22 treatment treatment NN cord-015021-pol2qm74 6166 23 of of IN cord-015021-pol2qm74 6166 24 sepsis sepsis NN cord-015021-pol2qm74 6166 25 . . . cord-015021-pol2qm74 6167 1 There there EX cord-015021-pol2qm74 6167 2 are be VBP cord-015021-pol2qm74 6167 3 three three CD cord-015021-pol2qm74 6167 4 basic basic JJ cord-015021-pol2qm74 6167 5 types type NNS cord-015021-pol2qm74 6167 6 of of IN cord-015021-pol2qm74 6167 7 animal animal NN cord-015021-pol2qm74 6167 8 models model NNS cord-015021-pol2qm74 6167 9 : : : cord-015021-pol2qm74 6167 10 ( ( -LRB- cord-015021-pol2qm74 6167 11 1 1 LS cord-015021-pol2qm74 6167 12 ) ) -RRB- cord-015021-pol2qm74 6167 13 toxicity toxicity NN cord-015021-pol2qm74 6167 14 models model NNS cord-015021-pol2qm74 6167 15 with with IN cord-015021-pol2qm74 6167 16 injection injection NN cord-015021-pol2qm74 6167 17 of of IN cord-015021-pol2qm74 6167 18 bacterial bacterial JJ cord-015021-pol2qm74 6167 19 endotoxin endotoxin NN cord-015021-pol2qm74 6167 20 or or CC cord-015021-pol2qm74 6167 21 exotoxins exotoxin NNS cord-015021-pol2qm74 6167 22 ; ; , cord-015021-pol2qm74 6167 23 ( ( -LRB- cord-015021-pol2qm74 6167 24 2 2 LS cord-015021-pol2qm74 6167 25 ) ) -RRB- cord-015021-pol2qm74 6167 26 live live VB cord-015021-pol2qm74 6167 27 or or CC cord-015021-pol2qm74 6167 28 killed kill VBD cord-015021-pol2qm74 6167 29 bacterial bacterial JJ cord-015021-pol2qm74 6167 30 challenge challenge NN cord-015021-pol2qm74 6167 31 models model NNS cord-015021-pol2qm74 6167 32 ; ; , cord-015021-pol2qm74 6167 33 ( ( -LRB- cord-015021-pol2qm74 6167 34 3 3 LS cord-015021-pol2qm74 6167 35 ) ) -RRB- cord-015021-pol2qm74 6167 36 actual actual JJ cord-015021-pol2qm74 6167 37 infection infection NN cord-015021-pol2qm74 6167 38 models model NNS cord-015021-pol2qm74 6167 39 . . . cord-015021-pol2qm74 6168 1 All all DT cord-015021-pol2qm74 6168 2 models model NNS cord-015021-pol2qm74 6168 3 employ employ VBP cord-015021-pol2qm74 6168 4 some some DT cord-015021-pol2qm74 6168 5 form form NN cord-015021-pol2qm74 6168 6 of of IN cord-015021-pol2qm74 6168 7 external external JJ cord-015021-pol2qm74 6168 8 manipulation manipulation NN cord-015021-pol2qm74 6168 9 under under IN cord-015021-pol2qm74 6168 10 controlled control VBN cord-015021-pol2qm74 6168 11 conditions condition NNS cord-015021-pol2qm74 6168 12 to to TO cord-015021-pol2qm74 6168 13 induce induce VB cord-015021-pol2qm74 6168 14 sepsis sepsis NN cord-015021-pol2qm74 6168 15 and and CC cord-015021-pol2qm74 6168 16 to to TO cord-015021-pol2qm74 6168 17 analyze analyze VB cord-015021-pol2qm74 6168 18 potential potential JJ cord-015021-pol2qm74 6168 19 therapeutic therapeutic JJ cord-015021-pol2qm74 6168 20 efficacy efficacy NN cord-015021-pol2qm74 6168 21 . . . cord-015021-pol2qm74 6169 1 These these DT cord-015021-pol2qm74 6169 2 experimental experimental JJ cord-015021-pol2qm74 6169 3 requirements requirement NNS cord-015021-pol2qm74 6169 4 may may MD cord-015021-pol2qm74 6169 5 limit limit VB cord-015021-pol2qm74 6169 6 the the DT cord-015021-pol2qm74 6169 7 ability ability NN cord-015021-pol2qm74 6169 8 of of IN cord-015021-pol2qm74 6169 9 animal animal NN cord-015021-pol2qm74 6169 10 models model NNS cord-015021-pol2qm74 6169 11 to to TO cord-015021-pol2qm74 6169 12 accurately accurately RB cord-015021-pol2qm74 6169 13 predict predict VB cord-015021-pol2qm74 6169 14 the the DT cord-015021-pol2qm74 6169 15 clinical clinical JJ cord-015021-pol2qm74 6169 16 value value NN cord-015021-pol2qm74 6169 17 of of IN cord-015021-pol2qm74 6169 18 new new JJ cord-015021-pol2qm74 6169 19 agents agent NNS cord-015021-pol2qm74 6169 20 in in IN cord-015021-pol2qm74 6169 21 human human JJ cord-015021-pol2qm74 6169 22 sepsis sepsis NN cord-015021-pol2qm74 6169 23 . . . cord-015021-pol2qm74 6170 1 Four four CD cord-015021-pol2qm74 6170 2 major major JJ cord-015021-pol2qm74 6170 3 end end NN cord-015021-pol2qm74 6170 4 points point NNS cord-015021-pol2qm74 6170 5 are be VBP cord-015021-pol2qm74 6170 6 analyzed analyze VBN cord-015021-pol2qm74 6170 7 in in IN cord-015021-pol2qm74 6170 8 the the DT cord-015021-pol2qm74 6170 9 various various JJ cord-015021-pol2qm74 6170 10 animal animal NN cord-015021-pol2qm74 6170 11 models model NNS cord-015021-pol2qm74 6170 12 : : : cord-015021-pol2qm74 6170 13 ( ( -LRB- cord-015021-pol2qm74 6170 14 1 1 LS cord-015021-pol2qm74 6170 15 ) ) -RRB- cord-015021-pol2qm74 6170 16 hemodynamic hemodynamic JJ cord-015021-pol2qm74 6170 17 parameters parameter NNS cord-015021-pol2qm74 6170 18 ; ; , cord-015021-pol2qm74 6170 19 ( ( -LRB- cord-015021-pol2qm74 6170 20 2 2 LS cord-015021-pol2qm74 6170 21 ) ) -RRB- cord-015021-pol2qm74 6170 22 modulation modulation NN cord-015021-pol2qm74 6170 23 of of IN cord-015021-pol2qm74 6170 24 host host NN cord-015021-pol2qm74 6170 25 - - HYPH cord-015021-pol2qm74 6170 26 derived derive VBN cord-015021-pol2qm74 6170 27 inflammatory inflammatory JJ cord-015021-pol2qm74 6170 28 mediators mediator NNS cord-015021-pol2qm74 6170 29 ; ; , cord-015021-pol2qm74 6170 30 ( ( -LRB- cord-015021-pol2qm74 6170 31 3 3 LS cord-015021-pol2qm74 6170 32 ) ) -RRB- cord-015021-pol2qm74 6170 33 resolution resolution NN cord-015021-pol2qm74 6170 34 of of IN cord-015021-pol2qm74 6170 35 end end JJ cord-015021-pol2qm74 6170 36 organ organ NN cord-015021-pol2qm74 6170 37 injury injury NN cord-015021-pol2qm74 6170 38 ; ; , cord-015021-pol2qm74 6170 39 or or CC cord-015021-pol2qm74 6170 40 ( ( -LRB- cord-015021-pol2qm74 6170 41 4 4 LS cord-015021-pol2qm74 6170 42 ) ) -RRB- cord-015021-pol2qm74 6170 43 lethality lethality NN cord-015021-pol2qm74 6170 44 . . . cord-015021-pol2qm74 6171 1 Each each DT cord-015021-pol2qm74 6171 2 animal animal NN cord-015021-pol2qm74 6171 3 model model NN cord-015021-pol2qm74 6171 4 has have VBZ cord-015021-pol2qm74 6171 5 certain certain JJ cord-015021-pol2qm74 6171 6 advantages advantage NNS cord-015021-pol2qm74 6171 7 and and CC cord-015021-pol2qm74 6171 8 limitations limitation NNS cord-015021-pol2qm74 6171 9 . . . cord-015021-pol2qm74 6172 1 Species species NN cord-015021-pol2qm74 6172 2 - - HYPH cord-015021-pol2qm74 6172 3 specific specific JJ cord-015021-pol2qm74 6172 4 differences difference NNS cord-015021-pol2qm74 6172 5 in in IN cord-015021-pol2qm74 6172 6 physiologic physiologic JJ cord-015021-pol2qm74 6172 7 and and CC cord-015021-pol2qm74 6172 8 immunologic immunologic JJ cord-015021-pol2qm74 6172 9 features feature NNS cord-015021-pol2qm74 6172 10 make make VBP cord-015021-pol2qm74 6172 11 it -PRON- PRP cord-015021-pol2qm74 6172 12 difficult difficult JJ cord-015021-pol2qm74 6172 13 to to TO cord-015021-pol2qm74 6172 14 directly directly RB cord-015021-pol2qm74 6172 15 extrapolate extrapolate VB cord-015021-pol2qm74 6172 16 the the DT cord-015021-pol2qm74 6172 17 results result NNS cord-015021-pol2qm74 6172 18 of of IN cord-015021-pol2qm74 6172 19 animal animal NN cord-015021-pol2qm74 6172 20 experiments experiment NNS cord-015021-pol2qm74 6172 21 into into IN cord-015021-pol2qm74 6172 22 clinical clinical JJ cord-015021-pol2qm74 6172 23 medicine medicine NN cord-015021-pol2qm74 6172 24 . . . cord-015021-pol2qm74 6173 1 While while IN cord-015021-pol2qm74 6173 2 no no DT cord-015021-pol2qm74 6173 3 ideal ideal JJ cord-015021-pol2qm74 6173 4 animal animal NN cord-015021-pol2qm74 6173 5 model model NN cord-015021-pol2qm74 6173 6 exists exist VBZ cord-015021-pol2qm74 6173 7 , , , cord-015021-pol2qm74 6173 8 consistent consistent JJ cord-015021-pol2qm74 6173 9 benefit benefit NN cord-015021-pol2qm74 6173 10 of of IN cord-015021-pol2qm74 6173 11 a a DT cord-015021-pol2qm74 6173 12 new new JJ cord-015021-pol2qm74 6173 13 immunotherapeutic immunotherapeutic JJ cord-015021-pol2qm74 6173 14 agent agent NN cord-015021-pol2qm74 6173 15 in in IN cord-015021-pol2qm74 6173 16 multiple multiple JJ cord-015021-pol2qm74 6173 17 animal animal NN cord-015021-pol2qm74 6173 18 systems system NNS cord-015021-pol2qm74 6173 19 provides provide VBZ cord-015021-pol2qm74 6173 20 the the DT cord-015021-pol2qm74 6173 21 most most RBS cord-015021-pol2qm74 6173 22 compelling compelling JJ cord-015021-pol2qm74 6173 23 preclinical preclinical JJ cord-015021-pol2qm74 6173 24 evidence evidence NN cord-015021-pol2qm74 6173 25 of of IN cord-015021-pol2qm74 6173 26 its -PRON- PRP$ cord-015021-pol2qm74 6173 27 therapeutic therapeutic JJ cord-015021-pol2qm74 6173 28 potential potential NN cord-015021-pol2qm74 6173 29 in in IN cord-015021-pol2qm74 6173 30 septic septic JJ cord-015021-pol2qm74 6173 31 patients patient NNS cord-015021-pol2qm74 6173 32 . . . cord-015021-pol2qm74 6174 1 Consensus consensus NN cord-015021-pol2qm74 6174 2 - - HYPH cord-015021-pol2qm74 6174 3 assisted assist VBN cord-015021-pol2qm74 6174 4 development development NN cord-015021-pol2qm74 6174 5 of of IN cord-015021-pol2qm74 6174 6 a a DT cord-015021-pol2qm74 6174 7 study study NN cord-015021-pol2qm74 6174 8 protocol protocol NN cord-015021-pol2qm74 6174 9 on on IN cord-015021-pol2qm74 6174 10 sepsis sepsis NN cord-015021-pol2qm74 6174 11 : : : cord-015021-pol2qm74 6174 12 an an DT cord-015021-pol2qm74 6174 13 important important JJ cord-015021-pol2qm74 6174 14 difference difference NN cord-015021-pol2qm74 6174 15 from from IN cord-015021-pol2qm74 6174 16 previous previous JJ cord-015021-pol2qm74 6174 17 randomized randomized JJ cord-015021-pol2qm74 6174 18 trials trial NNS cord-015021-pol2qm74 6174 19 There there EX cord-015021-pol2qm74 6174 20 have have VBP cord-015021-pol2qm74 6174 21 been be VBN cord-015021-pol2qm74 6174 22 several several JJ cord-015021-pol2qm74 6174 23 , , , cord-015021-pol2qm74 6174 24 and and CC cord-015021-pol2qm74 6174 25 perhaps perhaps RB cord-015021-pol2qm74 6174 26 too too RB cord-015021-pol2qm74 6174 27 many many JJ cord-015021-pol2qm74 6174 28 metaanalyses metaanalyse NNS cord-015021-pol2qm74 6174 29 of of IN cord-015021-pol2qm74 6174 30 cliuical cliuical JJ cord-015021-pol2qm74 6174 31 trials trial NNS cord-015021-pol2qm74 6174 32 on on IN cord-015021-pol2qm74 6174 33 surgical surgical JJ cord-015021-pol2qm74 6174 34 infections infection NNS cord-015021-pol2qm74 6174 35 , , , cord-015021-pol2qm74 6174 36 but but CC cord-015021-pol2qm74 6174 37 their -PRON- PRP$ cord-015021-pol2qm74 6174 38 results result NNS cord-015021-pol2qm74 6174 39 have have VBP cord-015021-pol2qm74 6174 40 only only RB cord-015021-pol2qm74 6174 41 rarely rarely RB cord-015021-pol2qm74 6174 42 been be VBN cord-015021-pol2qm74 6174 43 incorporated incorporate VBN cord-015021-pol2qm74 6174 44 into into IN cord-015021-pol2qm74 6174 45 the the DT cord-015021-pol2qm74 6174 46 design design NN cord-015021-pol2qm74 6174 47 of of IN cord-015021-pol2qm74 6174 48 new new JJ cord-015021-pol2qm74 6174 49 randomized randomized JJ cord-015021-pol2qm74 6174 50 trials trial NNS cord-015021-pol2qm74 6174 51 in in IN cord-015021-pol2qm74 6174 52 sepsis sepsis NN cord-015021-pol2qm74 6174 53 . . . cord-015021-pol2qm74 6175 1 Metaanalysis Metaanalysis NNP cord-015021-pol2qm74 6175 2 is be VBZ cord-015021-pol2qm74 6175 3 retrospective retrospective JJ cord-015021-pol2qm74 6175 4 . . . cord-015021-pol2qm74 6176 1 It -PRON- PRP cord-015021-pol2qm74 6176 2 seems seem VBZ cord-015021-pol2qm74 6176 3 more more RBR cord-015021-pol2qm74 6176 4 important important JJ cord-015021-pol2qm74 6176 5 to to TO cord-015021-pol2qm74 6176 6 analyse analyse VB cord-015021-pol2qm74 6176 7 and and CC cord-015021-pol2qm74 6176 8 to to TO cord-015021-pol2qm74 6176 9 criticize criticize VB cord-015021-pol2qm74 6176 10 the the DT cord-015021-pol2qm74 6176 11 design design NN cord-015021-pol2qm74 6176 12 of of IN cord-015021-pol2qm74 6176 13 tria tria NNP cord-015021-pol2qm74 6176 14 / / SYM cord-015021-pol2qm74 6176 15 s s NNP cord-015021-pol2qm74 6176 16 before before IN cord-015021-pol2qm74 6176 17 they -PRON- PRP cord-015021-pol2qm74 6176 18 are be VBP cord-015021-pol2qm74 6176 19 ongoing ongoing JJ cord-015021-pol2qm74 6176 20 . . . cord-015021-pol2qm74 6177 1 Incorporation incorporation NN cord-015021-pol2qm74 6177 2 of of IN cord-015021-pol2qm74 6177 3 that that DT cord-015021-pol2qm74 6177 4 into into IN cord-015021-pol2qm74 6177 5 development development NN cord-015021-pol2qm74 6177 6 of of IN cord-015021-pol2qm74 6177 7 a a DT cord-015021-pol2qm74 6177 8 study study NN cord-015021-pol2qm74 6177 9 protocol protocol NN cord-015021-pol2qm74 6177 10 is be VBZ cord-015021-pol2qm74 6177 11 the the DT cord-015021-pol2qm74 6177 12 aim aim NN cord-015021-pol2qm74 6177 13 of of IN cord-015021-pol2qm74 6177 14 the the DT cord-015021-pol2qm74 6177 15 following follow VBG cord-015021-pol2qm74 6177 16 procedure procedure NN cord-015021-pol2qm74 6177 17 : : : cord-015021-pol2qm74 6177 18 The the DT cord-015021-pol2qm74 6177 19 time time NN cord-015021-pol2qm74 6177 20 - - HYPH cord-015021-pol2qm74 6177 21 schedule schedule NN cord-015021-pol2qm74 6177 22 of of IN cord-015021-pol2qm74 6177 23 about about RB cord-015021-pol2qm74 6177 24 two two CD cord-015021-pol2qm74 6177 25 years year NNS cord-015021-pol2qm74 6177 26 should should MD cord-015021-pol2qm74 6177 27 include include VB cord-015021-pol2qm74 6177 28 further further JJ cord-015021-pol2qm74 6177 29 cell cell NN cord-015021-pol2qm74 6177 30 culture culture NN cord-015021-pol2qm74 6177 31 and and CC cord-015021-pol2qm74 6177 32 animal animal NN cord-015021-pol2qm74 6177 33 experiments experiment NNS cord-015021-pol2qm74 6177 34 after after IN cord-015021-pol2qm74 6177 35 the the DT cord-015021-pol2qm74 6177 36 first first JJ cord-015021-pol2qm74 6177 37 successful successful JJ cord-015021-pol2qm74 6177 38 studies study NNS cord-015021-pol2qm74 6177 39 showing show VBG cord-015021-pol2qm74 6177 40 effectiveness effectiveness NN cord-015021-pol2qm74 6177 41 . . . cord-015021-pol2qm74 6178 1 Exhaustive exhaustive JJ cord-015021-pol2qm74 6178 2 evidence evidence NN cord-015021-pol2qm74 6178 3 for for IN cord-015021-pol2qm74 6178 4 a a DT cord-015021-pol2qm74 6178 5 dose dose NN cord-015021-pol2qm74 6178 6 - - HYPH cord-015021-pol2qm74 6178 7 dependent dependent JJ cord-015021-pol2qm74 6178 8 cost cost NN cord-015021-pol2qm74 6178 9 - - HYPH cord-015021-pol2qm74 6178 10 banefit banefit NN cord-015021-pol2qm74 6178 11 and and CC cord-015021-pol2qm74 6178 12 near near IN cord-015021-pol2qm74 6178 13 complete complete JJ cord-015021-pol2qm74 6178 14 explanations explanation NNS cord-015021-pol2qm74 6178 15 of of IN cord-015021-pol2qm74 6178 16 the the DT cord-015021-pol2qm74 6178 17 pathomechanism pathomechanism NN cord-015021-pol2qm74 6178 18 should should MD cord-015021-pol2qm74 6178 19 not not RB cord-015021-pol2qm74 6178 20 be be VB cord-015021-pol2qm74 6178 21 awaited await VBN cord-015021-pol2qm74 6178 22 for for IN cord-015021-pol2qm74 6178 23 development development NN cord-015021-pol2qm74 6178 24 of of IN cord-015021-pol2qm74 6178 25 the the DT cord-015021-pol2qm74 6178 26 protocol protocol NN cord-015021-pol2qm74 6178 27 of of IN cord-015021-pol2qm74 6178 28 the the DT cord-015021-pol2qm74 6178 29 clinical clinical JJ cord-015021-pol2qm74 6178 30 study study NN cord-015021-pol2qm74 6178 31 . . . cord-015021-pol2qm74 6179 1 However however RB cord-015021-pol2qm74 6179 2 , , , cord-015021-pol2qm74 6179 3 a a DT cord-015021-pol2qm74 6179 4 discussion discussion NN cord-015021-pol2qm74 6179 5 forum forum NN cord-015021-pol2qm74 6179 6 of of IN cord-015021-pol2qm74 6179 7 experts expert NNS cord-015021-pol2qm74 6179 8 should should MD cord-015021-pol2qm74 6179 9 be be VB cord-015021-pol2qm74 6179 10 performed perform VBN cord-015021-pol2qm74 6179 11 in in IN cord-015021-pol2qm74 6179 12 a a DT cord-015021-pol2qm74 6179 13 recently recently RB cord-015021-pol2qm74 6179 14 published publish VBN cord-015021-pol2qm74 6179 15 , , , cord-015021-pol2qm74 6179 16 almost almost RB cord-015021-pol2qm74 6179 17 perfect perfect JJ cord-015021-pol2qm74 6179 18 trial trial NN cord-015021-pol2qm74 6179 19 in in IN cord-015021-pol2qm74 6179 20 order order NN cord-015021-pol2qm74 6179 21 to to TO cord-015021-pol2qm74 6179 22 see see VB cord-015021-pol2qm74 6179 23 the the DT cord-015021-pol2qm74 6179 24 frontiers frontier NNS cord-015021-pol2qm74 6179 25 of of IN cord-015021-pol2qm74 6179 26 the the DT cord-015021-pol2qm74 6179 27 present present JJ cord-015021-pol2qm74 6179 28 research research NN cord-015021-pol2qm74 6179 29 in in IN cord-015021-pol2qm74 6179 30 cell cell NN cord-015021-pol2qm74 6179 31 and and CC cord-015021-pol2qm74 6179 32 molecular molecular JJ cord-015021-pol2qm74 6179 33 biology biology NN cord-015021-pol2qm74 6179 34 , , , cord-015021-pol2qm74 6179 35 clinical clinical JJ cord-015021-pol2qm74 6179 36 pharmacology pharmacology NN cord-015021-pol2qm74 6179 37 , , , cord-015021-pol2qm74 6179 38 statistics statistic NNS cord-015021-pol2qm74 6179 39 and and CC cord-015021-pol2qm74 6179 40 decision decision NN cord-015021-pol2qm74 6179 41 making making NN cord-015021-pol2qm74 6179 42 . . . cord-015021-pol2qm74 6180 1 This this DT cord-015021-pol2qm74 6180 2 should should MD cord-015021-pol2qm74 6180 3 be be VB cord-015021-pol2qm74 6180 4 followed follow VBN cord-015021-pol2qm74 6180 5 by by IN cord-015021-pol2qm74 6180 6 a a DT cord-015021-pol2qm74 6180 7 metaanalysis metaanalysis NN cord-015021-pol2qm74 6180 8 of of IN cord-015021-pol2qm74 6180 9 at at RB cord-015021-pol2qm74 6180 10 least least RBS cord-015021-pol2qm74 6180 11 10 10 CD cord-015021-pol2qm74 6180 12 study study NN cord-015021-pol2qm74 6180 13 designs design NNS cord-015021-pol2qm74 6180 14 on on IN cord-015021-pol2qm74 6180 15 sepsis sepsis NN cord-015021-pol2qm74 6180 16 with with IN cord-015021-pol2qm74 6180 17 methods method NNS cord-015021-pol2qm74 6180 18 of of IN cord-015021-pol2qm74 6180 19 formalized formalize VBN cord-015021-pol2qm74 6180 20 medical medical JJ cord-015021-pol2qm74 6180 21 decision decision NN cord-015021-pol2qm74 6180 22 making make VBG cord-015021-pol2qm74 6180 23 ( ( -LRB- cord-015021-pol2qm74 6180 24 decision decision NN cord-015021-pol2qm74 6180 25 tree tree NN cord-015021-pol2qm74 6180 26 ) ) -RRB- cord-015021-pol2qm74 6180 27 . . . cord-015021-pol2qm74 6181 1 Clinical clinical JJ cord-015021-pol2qm74 6181 2 algorithms algorithm NNS cord-015021-pol2qm74 6181 3 -developed -develope VBD cord-015021-pol2qm74 6182 1 by by IN cord-015021-pol2qm74 6182 2 objective objective JJ cord-015021-pol2qm74 6182 3 methods method NNS cord-015021-pol2qm74 6182 4 including include VBG cord-015021-pol2qm74 6182 5 nominal nominal JJ cord-015021-pol2qm74 6182 6 group group NN cord-015021-pol2qm74 6182 7 processes process NNS cord-015021-pol2qm74 6183 1 -should -should MD cord-015021-pol2qm74 6183 2 be be VB cord-015021-pol2qm74 6183 3 developed develop VBN cord-015021-pol2qm74 6183 4 to to TO cord-015021-pol2qm74 6183 5 standardize standardize VB cord-015021-pol2qm74 6183 6 any any DT cord-015021-pol2qm74 6183 7 concomitant concomitant JJ cord-015021-pol2qm74 6183 8 treatment treatment NN cord-015021-pol2qm74 6183 9 in in IN cord-015021-pol2qm74 6183 10 the the DT cord-015021-pol2qm74 6183 11 centers center NNS cord-015021-pol2qm74 6183 12 considered consider VBN cord-015021-pol2qm74 6183 13 for for IN cord-015021-pol2qm74 6183 14 a a DT cord-015021-pol2qm74 6183 15 multinentre multinentre NN cord-015021-pol2qm74 6183 16 trial trial NN cord-015021-pol2qm74 6183 17 . . . cord-015021-pol2qm74 6184 1 The the DT cord-015021-pol2qm74 6184 2 latter latter JJ cord-015021-pol2qm74 6184 3 is be VBZ cord-015021-pol2qm74 6184 4 usually usually RB cord-015021-pol2qm74 6184 5 necessary necessary JJ cord-015021-pol2qm74 6184 6 in in IN cord-015021-pol2qm74 6184 7 the the DT cord-015021-pol2qm74 6184 8 field field NN cord-015021-pol2qm74 6184 9 of of IN cord-015021-pol2qm74 6184 10 sepsis sepsis NN cord-015021-pol2qm74 6184 11 . . . cord-015021-pol2qm74 6185 1 Finally finally RB cord-015021-pol2qm74 6185 2 , , , cord-015021-pol2qm74 6185 3 a a DT cord-015021-pol2qm74 6185 4 pilot pilot NN cord-015021-pol2qm74 6185 5 study study NN cord-015021-pol2qm74 6185 6 should should MD cord-015021-pol2qm74 6185 7 be be VB cord-015021-pol2qm74 6185 8 performed perform VBN cord-015021-pol2qm74 6185 9 to to TO cord-015021-pol2qm74 6185 10 demonstrate demonstrate VB cord-015021-pol2qm74 6185 11 not not RB cord-015021-pol2qm74 6185 12 only only RB cord-015021-pol2qm74 6185 13 feasability feasability NN cord-015021-pol2qm74 6185 14 , , , cord-015021-pol2qm74 6185 15 but but CC cord-015021-pol2qm74 6185 16 to to TO cord-015021-pol2qm74 6185 17 learn learn VB cord-015021-pol2qm74 6185 18 about about IN cord-015021-pol2qm74 6185 19 all all DT cord-015021-pol2qm74 6185 20 possible possible JJ cord-015021-pol2qm74 6185 21 types type NNS cord-015021-pol2qm74 6185 22 of of IN cord-015021-pol2qm74 6185 23 interventions intervention NNS cord-015021-pol2qm74 6185 24 which which WDT cord-015021-pol2qm74 6185 25 modify modify VBP cord-015021-pol2qm74 6185 26 endpoints endpoint NNS cord-015021-pol2qm74 6185 27 as as IN cord-015021-pol2qm74 6185 28 response response NN cord-015021-pol2qm74 6185 29 variables variable NNS cord-015021-pol2qm74 6185 30 . . . cord-015021-pol2qm74 6186 1 Especially especially RB cord-015021-pol2qm74 6186 2 mortality mortality NN cord-015021-pol2qm74 6186 3 is be VBZ cord-015021-pol2qm74 6186 4 not not RB cord-015021-pol2qm74 6186 5 free free JJ cord-015021-pol2qm74 6186 6 from from IN cord-015021-pol2qm74 6186 7 such such JJ cord-015021-pol2qm74 6186 8 effects effect NNS cord-015021-pol2qm74 6186 9 . . . cord-015021-pol2qm74 6187 1 The the DT cord-015021-pol2qm74 6187 2 time time NN cord-015021-pol2qm74 6187 3 for for IN cord-015021-pol2qm74 6187 4 the the DT cord-015021-pol2qm74 6187 5 individual individual JJ cord-015021-pol2qm74 6187 6 phases phase NNS cord-015021-pol2qm74 6187 7 of of IN cord-015021-pol2qm74 6187 8 this this DT cord-015021-pol2qm74 6187 9 consensus consensus NN cord-015021-pol2qm74 6187 10 - - HYPH cord-015021-pol2qm74 6187 11 assisted assist VBN cord-015021-pol2qm74 6187 12 process process NN cord-015021-pol2qm74 6187 13 of of IN cord-015021-pol2qm74 6187 14 protocol protocol NN cord-015021-pol2qm74 6187 15 development development NN cord-015021-pol2qm74 6187 16 have have VBP cord-015021-pol2qm74 6187 17 to to TO cord-015021-pol2qm74 6187 18 be be VB cord-015021-pol2qm74 6187 19 shortened shorten VBN cord-015021-pol2qm74 6187 20 by by IN cord-015021-pol2qm74 6187 21 their -PRON- PRP$ cord-015021-pol2qm74 6187 22 temporal temporal JJ cord-015021-pol2qm74 6187 23 hiterloeldug hiterloeldug NN cord-015021-pol2qm74 6187 24 . . . cord-015021-pol2qm74 6188 1 Due due IN cord-015021-pol2qm74 6188 2 to to IN cord-015021-pol2qm74 6188 3 the the DT cord-015021-pol2qm74 6188 4 fast fast JJ cord-015021-pol2qm74 6188 5 discovery discovery NN cord-015021-pol2qm74 6188 6 of of IN cord-015021-pol2qm74 6188 7 new new JJ cord-015021-pol2qm74 6188 8 chemical chemical NN cord-015021-pol2qm74 6188 9 factors factor NNS cord-015021-pol2qm74 6188 10 in in IN cord-015021-pol2qm74 6188 11 SIRS SIRS NNP cord-015021-pol2qm74 6188 12 it -PRON- PRP cord-015021-pol2qm74 6188 13 wilt wilt MD cord-015021-pol2qm74 6188 14 otherwise otherwise RB cord-015021-pol2qm74 6188 15 be be VB cord-015021-pol2qm74 6188 16 impossible impossible JJ cord-015021-pol2qm74 6188 17 to to TO cord-015021-pol2qm74 6188 18 come come VB cord-015021-pol2qm74 6188 19 up up RP cord-015021-pol2qm74 6188 20 with with IN cord-015021-pol2qm74 6188 21 results result NNS cord-015021-pol2qm74 6188 22 of of IN cord-015021-pol2qm74 6188 23 randomized randomized JJ cord-015021-pol2qm74 6188 24 trials trial NNS cord-015021-pol2qm74 6188 25 which which WDT cord-015021-pol2qm74 6188 26 are be VBP cord-015021-pol2qm74 6188 27 fascinating fascinating JJ cord-015021-pol2qm74 6188 28 enough enough RB cord-015021-pol2qm74 6188 29 to to TO cord-015021-pol2qm74 6188 30 be be VB cord-015021-pol2qm74 6188 31 incorporated incorporate VBN cord-015021-pol2qm74 6188 32 in in IN cord-015021-pol2qm74 6188 33 daily daily JJ cord-015021-pol2qm74 6188 34 routine routine JJ cord-015021-pol2qm74 6188 35 treatment treatment NN cord-015021-pol2qm74 6188 36 . . . cord-015021-pol2qm74 6189 1 Severity severity NN cord-015021-pol2qm74 6189 2 scoring scoring NN cord-015021-pol2qm74 6189 3 systems system NNS cord-015021-pol2qm74 6189 4 are be VBP cord-015021-pol2qm74 6189 5 intended intend VBN cord-015021-pol2qm74 6189 6 to to TO cord-015021-pol2qm74 6189 7 provide provide VB cord-015021-pol2qm74 6189 8 a a DT cord-015021-pol2qm74 6189 9 population population NN cord-015021-pol2qm74 6189 10 - - HYPH cord-015021-pol2qm74 6189 11 based base VBN cord-015021-pol2qm74 6189 12 estimate estimate NN cord-015021-pol2qm74 6189 13 for for IN cord-015021-pol2qm74 6189 14 the the DT cord-015021-pol2qm74 6189 15 risk risk NN cord-015021-pol2qm74 6189 16 of of IN cord-015021-pol2qm74 6189 17 an an DT cord-015021-pol2qm74 6189 18 unwanted unwanted JJ cord-015021-pol2qm74 6189 19 outcome outcome NN cord-015021-pol2qm74 6189 20 resulting result VBG cord-015021-pol2qm74 6189 21 from from IN cord-015021-pol2qm74 6189 22 some some DT cord-015021-pol2qm74 6189 23 disease disease NN cord-015021-pol2qm74 6189 24 process process NN cord-015021-pol2qm74 6189 25 . . . cord-015021-pol2qm74 6190 1 In in IN cord-015021-pol2qm74 6190 2 the the DT cord-015021-pol2qm74 6190 3 area area NN cord-015021-pol2qm74 6190 4 of of IN cord-015021-pol2qm74 6190 5 infections infection NNS cord-015021-pol2qm74 6190 6 and and CC cord-015021-pol2qm74 6190 7 the the DT cord-015021-pol2qm74 6190 8 " " `` cord-015021-pol2qm74 6190 9 septic septic JJ cord-015021-pol2qm74 6190 10 " " '' cord-015021-pol2qm74 6190 11 response response NN cord-015021-pol2qm74 6190 12 , , , cord-015021-pol2qm74 6190 13 this this DT cord-015021-pol2qm74 6190 14 has have VBZ cord-015021-pol2qm74 6190 15 routinely routinely RB cord-015021-pol2qm74 6190 16 been be VBN cord-015021-pol2qm74 6190 17 defined define VBN cord-015021-pol2qm74 6190 18 as as IN cord-015021-pol2qm74 6190 19 death death NN cord-015021-pol2qm74 6190 20 . . . cord-015021-pol2qm74 6191 1 For for IN cord-015021-pol2qm74 6191 2 anti anti JJ cord-015021-pol2qm74 6191 3 - - JJ cord-015021-pol2qm74 6191 4 infective infective JJ cord-015021-pol2qm74 6191 5 trials trial NNS cord-015021-pol2qm74 6191 6 , , , cord-015021-pol2qm74 6191 7 there there EX cord-015021-pol2qm74 6191 8 has have VBZ cord-015021-pol2qm74 6191 9 been be VBN cord-015021-pol2qm74 6191 10 a a DT cord-015021-pol2qm74 6191 11 reasonable reasonable JJ cord-015021-pol2qm74 6191 12 correlation correlation NN cord-015021-pol2qm74 6191 13 of of IN cord-015021-pol2qm74 6191 14 severity severity NN cord-015021-pol2qm74 6191 15 ( ( -LRB- cord-015021-pol2qm74 6191 16 APACHE APACHE NNP cord-015021-pol2qm74 6191 17 ll will NNP cord-015021-pol2qm74 6191 18 ) ) -RRB- cord-015021-pol2qm74 6191 19 with with IN cord-015021-pol2qm74 6191 20 outcome outcome NN cord-015021-pol2qm74 6191 21 measured measure VBN cord-015021-pol2qm74 6191 22 as as IN cord-015021-pol2qm74 6191 23 persistent persistent JJ cord-015021-pol2qm74 6191 24 or or CC cord-015021-pol2qm74 6191 25 recurrent recurrent JJ cord-015021-pol2qm74 6191 26 infection infection NN cord-015021-pol2qm74 6191 27 , , , cord-015021-pol2qm74 6191 28 but but CC cord-015021-pol2qm74 6191 29 this this DT cord-015021-pol2qm74 6191 30 is be VBZ cord-015021-pol2qm74 6191 31 not not RB cord-015021-pol2qm74 6191 32 as as RB cord-015021-pol2qm74 6191 33 robust robust JJ cord-015021-pol2qm74 6191 34 as as IN cord-015021-pol2qm74 6191 35 the the DT cord-015021-pol2qm74 6191 36 association association NN cord-015021-pol2qm74 6191 37 with with IN cord-015021-pol2qm74 6191 38 mortality mortality NN cord-015021-pol2qm74 6191 39 . . . cord-015021-pol2qm74 6192 1 It -PRON- PRP cord-015021-pol2qm74 6192 2 is be VBZ cord-015021-pol2qm74 6192 3 expected expect VBN cord-015021-pol2qm74 6192 4 that that IN cord-015021-pol2qm74 6192 5 non non JJ cord-015021-pol2qm74 6192 6 - - JJ cord-015021-pol2qm74 6192 7 lethal lethal JJ cord-015021-pol2qm74 6192 8 failure failure NN cord-015021-pol2qm74 6192 9 would would MD cord-015021-pol2qm74 6192 10 not not RB cord-015021-pol2qm74 6192 11 immediately immediately RB cord-015021-pol2qm74 6192 12 correlate correlate VB cord-015021-pol2qm74 6192 13 with with IN cord-015021-pol2qm74 6192 14 disturbed disturbed JJ cord-015021-pol2qm74 6192 15 physiology physiology NN cord-015021-pol2qm74 6192 16 : : : cord-015021-pol2qm74 6193 1 the the DT cord-015021-pol2qm74 6193 2 basis basis NN cord-015021-pol2qm74 6193 3 for for IN cord-015021-pol2qm74 6193 4 antiinfective antiinfective JJ cord-015021-pol2qm74 6193 5 failure failure NN cord-015021-pol2qm74 6193 6 depends depend VBZ cord-015021-pol2qm74 6193 7 on on IN cord-015021-pol2qm74 6193 8 a a DT cord-015021-pol2qm74 6193 9 variety variety NN cord-015021-pol2qm74 6193 10 of of IN cord-015021-pol2qm74 6193 11 factors factor NNS cord-015021-pol2qm74 6193 12 not not RB cord-015021-pol2qm74 6193 13 measured measure VBN cord-015021-pol2qm74 6193 14 in in IN cord-015021-pol2qm74 6193 15 severity severity NN cord-015021-pol2qm74 6193 16 scoring scoring NN cord-015021-pol2qm74 6193 17 , , , cord-015021-pol2qm74 6193 18 such such JJ cord-015021-pol2qm74 6193 19 as as IN cord-015021-pol2qm74 6193 20 type type NN cord-015021-pol2qm74 6193 21 of of IN cord-015021-pol2qm74 6193 22 infecting infect VBG cord-015021-pol2qm74 6193 23 organisms organism NNS cord-015021-pol2qm74 6193 24 , , , cord-015021-pol2qm74 6193 25 density density NN cord-015021-pol2qm74 6193 26 and and CC cord-015021-pol2qm74 6193 27 susceptibility susceptibility NN cord-015021-pol2qm74 6193 28 to to IN cord-015021-pol2qm74 6193 29 administered administer VBN cord-015021-pol2qm74 6193 30 antimicrobia[s antimicrobia[s NNP cord-015021-pol2qm74 6193 31 , , , cord-015021-pol2qm74 6193 32 and and CC cord-015021-pol2qm74 6193 33 anatomic anatomic JJ cord-015021-pol2qm74 6193 34 features feature NNS cord-015021-pol2qm74 6193 35 of of IN cord-015021-pol2qm74 6193 36 infection infection NN cord-015021-pol2qm74 6193 37 ( ( -LRB- cord-015021-pol2qm74 6193 38 e.g. e.g. RB cord-015021-pol2qm74 6193 39 , , , cord-015021-pol2qm74 6193 40 pancreatic pancreatic NN cord-015021-pol2qm74 6193 41 ) ) -RRB- cord-015021-pol2qm74 6193 42 . . . cord-015021-pol2qm74 6194 1 Severity severity NN cord-015021-pol2qm74 6194 2 scoring scoring NN cord-015021-pol2qm74 6194 3 is be VBZ cord-015021-pol2qm74 6194 4 important important JJ cord-015021-pol2qm74 6194 5 in in IN cord-015021-pol2qm74 6194 6 differentiating differentiate VBG cord-015021-pol2qm74 6194 7 these these DT cord-015021-pol2qm74 6194 8 " " `` cord-015021-pol2qm74 6194 9 categorical categorical JJ cord-015021-pol2qm74 6194 10 " " '' cord-015021-pol2qm74 6194 11 variables variable NNS cord-015021-pol2qm74 6194 12 from from IN cord-015021-pol2qm74 6194 13 continuous continuous JJ cord-015021-pol2qm74 6194 14 ( ( -LRB- cord-015021-pol2qm74 6194 15 physiologic physiologic JJ cord-015021-pol2qm74 6194 16 ) ) -RRB- cord-015021-pol2qm74 6194 17 variables variable NNS cord-015021-pol2qm74 6194 18 . . . cord-015021-pol2qm74 6195 1 There there EX cord-015021-pol2qm74 6195 2 are be VBP cord-015021-pol2qm74 6195 3 , , , cord-015021-pol2qm74 6195 4 additionally additionally RB cord-015021-pol2qm74 6195 5 , , , cord-015021-pol2qm74 6195 6 a a DT cord-015021-pol2qm74 6195 7 series series NN cord-015021-pol2qm74 6195 8 of of IN cord-015021-pol2qm74 6195 9 problems problem NNS cord-015021-pol2qm74 6195 10 related relate VBN cord-015021-pol2qm74 6195 11 to to IN cord-015021-pol2qm74 6195 12 the the DT cord-015021-pol2qm74 6195 13 cause cause NN cord-015021-pol2qm74 6195 14 of of IN cord-015021-pol2qm74 6195 15 death death NN cord-015021-pol2qm74 6195 16 in in IN cord-015021-pol2qm74 6195 17 relation relation NN cord-015021-pol2qm74 6195 18 to to IN cord-015021-pol2qm74 6195 19 severity severity NN cord-015021-pol2qm74 6195 20 scoring scoring NN cord-015021-pol2qm74 6195 21 . . . cord-015021-pol2qm74 6196 1 In in IN cord-015021-pol2qm74 6196 2 those those DT cord-015021-pol2qm74 6196 3 tdals tdal NNS cord-015021-pol2qm74 6196 4 in in IN cord-015021-pol2qm74 6196 5 which which WDT cord-015021-pol2qm74 6196 6 cause cause NN cord-015021-pol2qm74 6196 7 of of IN cord-015021-pol2qm74 6196 8 death death NN cord-015021-pol2qm74 6196 9 is be VBZ cord-015021-pol2qm74 6196 10 analyzed analyze VBN cord-015021-pol2qm74 6196 11 , , , cord-015021-pol2qm74 6196 12 high high JJ cord-015021-pol2qm74 6196 13 severity severity NN cord-015021-pol2qm74 6196 14 scores score NNS cord-015021-pol2qm74 6196 15 did do VBD cord-015021-pol2qm74 6196 16 not not RB cord-015021-pol2qm74 6196 17 routinely routinely RB cord-015021-pol2qm74 6196 18 predict predict VB cord-015021-pol2qm74 6196 19 death death NN cord-015021-pol2qm74 6196 20 as as IN cord-015021-pol2qm74 6196 21 an an DT cord-015021-pol2qm74 6196 22 immediate immediate JJ cord-015021-pol2qm74 6196 23 sequelae sequela NNS cord-015021-pol2qm74 6196 24 of of IN cord-015021-pol2qm74 6196 25 sepsis sepsis NN cord-015021-pol2qm74 6196 26 / / SYM cord-015021-pol2qm74 6196 27 septic septic JJ cord-015021-pol2qm74 6196 28 shock shock NN cord-015021-pol2qm74 6196 29 . . . cord-015021-pol2qm74 6197 1 Many many JJ cord-015021-pol2qm74 6197 2 of of IN cord-015021-pol2qm74 6197 3 the the DT cord-015021-pol2qm74 6197 4 predicted predict VBN cord-015021-pol2qm74 6197 5 deaths death NNS cord-015021-pol2qm74 6197 6 occurred occur VBD cord-015021-pol2qm74 6197 7 remotely remotely RB cord-015021-pol2qm74 6197 8 of of IN cord-015021-pol2qm74 6197 9 progressive progressive JJ cord-015021-pol2qm74 6197 10 background background NN cord-015021-pol2qm74 6197 11 diseases disease NNS cord-015021-pol2qm74 6197 12 . . . cord-015021-pol2qm74 6198 1 Other other JJ cord-015021-pol2qm74 6198 2 important important JJ cord-015021-pol2qm74 6198 3 problems problem NNS cord-015021-pol2qm74 6198 4 with with IN cord-015021-pol2qm74 6198 5 severity severity NN cord-015021-pol2qm74 6198 6 scoring scoring NN cord-015021-pol2qm74 6198 7 have have VBP cord-015021-pol2qm74 6198 8 to to TO cord-015021-pol2qm74 6198 9 do do VB cord-015021-pol2qm74 6198 10 with with IN cord-015021-pol2qm74 6198 11 lead lead JJ cord-015021-pol2qm74 6198 12 - - HYPH cord-015021-pol2qm74 6198 13 time time NN cord-015021-pol2qm74 6198 14 bias bias NN cord-015021-pol2qm74 6198 15 : : : cord-015021-pol2qm74 6198 16 hew hew NNP cord-015021-pol2qm74 6198 17 long long JJ cord-015021-pol2qm74 6198 18 patients patient NNS cord-015021-pol2qm74 6198 19 were be VBD cord-015021-pol2qm74 6198 20 ill ill JJ cord-015021-pol2qm74 6198 21 before before IN cord-015021-pol2qm74 6198 22 entry entry NN cord-015021-pol2qm74 6198 23 into into IN cord-015021-pol2qm74 6198 24 the the DT cord-015021-pol2qm74 6198 25 study study NN cord-015021-pol2qm74 6198 26 . . . cord-015021-pol2qm74 6199 1 Statistical statistical JJ cord-015021-pol2qm74 6199 2 techniques technique NNS cord-015021-pol2qm74 6199 3 for for IN cord-015021-pol2qm74 6199 4 condensing condense VBG cord-015021-pol2qm74 6199 5 various various JJ cord-015021-pol2qm74 6199 6 categorical categorical JJ cord-015021-pol2qm74 6199 7 and and CC cord-015021-pol2qm74 6199 8 continuous continuous JJ cord-015021-pol2qm74 6199 9 variables variable NNS cord-015021-pol2qm74 6199 10 , , , cord-015021-pol2qm74 6199 11 as as RB cord-015021-pol2qm74 6199 12 well well RB cord-015021-pol2qm74 6199 13 as as IN cord-015021-pol2qm74 6199 14 factoring factor VBG cord-015021-pol2qm74 6199 15 in in IN cord-015021-pol2qm74 6199 16 information information NN cord-015021-pol2qm74 6199 17 requiring require VBG cord-015021-pol2qm74 6199 18 the the DT cord-015021-pol2qm74 6199 19 pharmacodynamics pharmacodynamic NNS cord-015021-pol2qm74 6199 20 of of IN cord-015021-pol2qm74 6199 21 agents agent NNS cord-015021-pol2qm74 6199 22 which which WDT cord-015021-pol2qm74 6199 23 affect affect VBP cord-015021-pol2qm74 6199 24 outcome outcome NN cord-015021-pol2qm74 6199 25 , , , cord-015021-pol2qm74 6199 26 are be VBP cord-015021-pol2qm74 6199 27 being be VBG cord-015021-pol2qm74 6199 28 developed develop VBN cord-015021-pol2qm74 6199 29 to to TO cord-015021-pol2qm74 6199 30 further further RB cord-015021-pol2qm74 6199 31 refine refine VB cord-015021-pol2qm74 6199 32 deviation deviation NN cord-015021-pol2qm74 6199 33 from from IN cord-015021-pol2qm74 6199 34 predictive predictive JJ cord-015021-pol2qm74 6199 35 equations equation NNS cord-015021-pol2qm74 6199 36 as as IN cord-015021-pol2qm74 6199 37 an an DT cord-015021-pol2qm74 6199 38 outcome outcome NN cord-015021-pol2qm74 6199 39 measure measure NN cord-015021-pol2qm74 6199 40 . . . cord-015021-pol2qm74 6200 1 Stepwise Stepwise NNP cord-015021-pol2qm74 6200 2 logistic logistic JJ cord-015021-pol2qm74 6200 3 regression regression NN cord-015021-pol2qm74 6200 4 analysis analysis NN cord-015021-pol2qm74 6200 5 has have VBZ cord-015021-pol2qm74 6200 6 identified identify VBN cord-015021-pol2qm74 6200 7 the the DT cord-015021-pol2qm74 6200 8 presence presence NN cord-015021-pol2qm74 6200 9 of of IN cord-015021-pol2qm74 6200 10 shock shock NN cord-015021-pol2qm74 6200 11 , , , cord-015021-pol2qm74 6200 12 intm intm NN cord-015021-pol2qm74 6200 13 - - HYPH cord-015021-pol2qm74 6200 14 abdominal abdominal JJ cord-015021-pol2qm74 6200 15 or or CC cord-015021-pol2qm74 6200 16 unknown unknown JJ cord-015021-pol2qm74 6200 17 source source NN cord-015021-pol2qm74 6200 18 of of IN cord-015021-pol2qm74 6200 19 infection infection NN cord-015021-pol2qm74 6200 20 , , , cord-015021-pol2qm74 6200 21 hospital hospital NN cord-015021-pol2qm74 6200 22 acquired acquire VBN cord-015021-pol2qm74 6200 23 infection infection NN cord-015021-pol2qm74 6200 24 , , , cord-015021-pol2qm74 6200 25 age age NN cord-015021-pol2qm74 6200 26 greater great JJR cord-015021-pol2qm74 6200 27 than than IN cord-015021-pol2qm74 6200 28 70 70 CD cord-015021-pol2qm74 6200 29 years year NNS cord-015021-pol2qm74 6200 30 , , , cord-015021-pol2qm74 6200 31 neutropenia neutropenia NN cord-015021-pol2qm74 6200 32 and and CC cord-015021-pol2qm74 6200 33 inappropriate inappropriate JJ cord-015021-pol2qm74 6200 34 antimicmbial antimicmbial JJ cord-015021-pol2qm74 6200 35 therapy therapy NN cord-015021-pol2qm74 6200 36 as as IN cord-015021-pol2qm74 6200 37 independent independent JJ cord-015021-pol2qm74 6200 38 variables variable NNS cord-015021-pol2qm74 6200 39 associated associate VBN cord-015021-pol2qm74 6200 40 with with IN cord-015021-pol2qm74 6200 41 increased increase VBN cord-015021-pol2qm74 6200 42 mortality mortality NN cord-015021-pol2qm74 6200 43 in in IN cord-015021-pol2qm74 6200 44 sepsis sepsis NN cord-015021-pol2qm74 6200 45 . . . cord-015021-pol2qm74 6201 1 Maldistribution maldistribution NN cord-015021-pol2qm74 6201 2 or or CC cord-015021-pol2qm74 6201 3 " " `` cord-015021-pol2qm74 6201 4 these these DT cord-015021-pol2qm74 6201 5 variables variable NNS cord-015021-pol2qm74 6201 6 is be VBZ cord-015021-pol2qm74 6201 7 a a DT cord-015021-pol2qm74 6201 8 concern concern NN cord-015021-pol2qm74 6201 9 in in IN cord-015021-pol2qm74 6201 10 targe targe NN cord-015021-pol2qm74 6201 11 randomized randomized JJ cord-015021-pol2qm74 6201 12 clinical clinical JJ cord-015021-pol2qm74 6201 13 studies study NNS cord-015021-pol2qm74 6201 14 . . . cord-015021-pol2qm74 6202 1 It -PRON- PRP cord-015021-pol2qm74 6202 2 should should MD cord-015021-pol2qm74 6202 3 be be VB cord-015021-pol2qm74 6202 4 noted note VBN cord-015021-pol2qm74 6202 5 that that IN cord-015021-pol2qm74 6202 6 only only RB cord-015021-pol2qm74 6202 7 the the DT cord-015021-pol2qm74 6202 8 selection selection NN cord-015021-pol2qm74 6202 9 of of IN cord-015021-pol2qm74 6202 10 antimicrobiaI antimicrobiaI NNP cord-015021-pol2qm74 6202 11 therapy therapy NN cord-015021-pol2qm74 6202 12 could could MD cord-015021-pol2qm74 6202 13 be be VB cord-015021-pol2qm74 6202 14 addre.~'sed addre.~'se VBN cord-015021-pol2qm74 6202 15 and and CC cord-015021-pol2qm74 6202 16 altered alter VBN cord-015021-pol2qm74 6202 17 at at IN cord-015021-pol2qm74 6202 18 the the DT cord-015021-pol2qm74 6202 19 time time NN cord-015021-pol2qm74 6202 20 of of IN cord-015021-pol2qm74 6202 21 enrollment enrollment NN cord-015021-pol2qm74 6202 22 in in IN cord-015021-pol2qm74 6202 23 a a DT cord-015021-pol2qm74 6202 24 sepsis sepsis NN cord-015021-pol2qm74 6202 25 clinics clinic NNS cord-015021-pol2qm74 6202 26 ] ] -RRB- cord-015021-pol2qm74 6202 27 trial trial NN cord-015021-pol2qm74 6202 28 . . . cord-015021-pol2qm74 6203 1 Inappropriate inappropriate JJ cord-015021-pol2qm74 6203 2 antimicrobial antimicrobial JJ cord-015021-pol2qm74 6203 3 therapy therapy NN cord-015021-pol2qm74 6203 4 has have VBZ cord-015021-pol2qm74 6203 5 been be VBN cord-015021-pol2qm74 6203 6 noted note VBN cord-015021-pol2qm74 6203 7 in in IN cord-015021-pol2qm74 6203 8 41%-66 41%-66 CD cord-015021-pol2qm74 6203 9 % % NN cord-015021-pol2qm74 6203 10 of of IN cord-015021-pol2qm74 6203 11 septic septic JJ cord-015021-pol2qm74 6203 12 patients patient NNS cord-015021-pol2qm74 6203 13 . . . cord-015021-pol2qm74 6204 1 Well well UH cord-015021-pol2qm74 6204 2 designed design VBN cord-015021-pol2qm74 6204 3 , , , cord-015021-pol2qm74 6204 4 randomized randomized JJ cord-015021-pol2qm74 6204 5 sepsis sepsis NN cord-015021-pol2qm74 6204 6 trials trial NNS cord-015021-pol2qm74 6204 7 do do VBP cord-015021-pol2qm74 6204 8 not not RB cord-015021-pol2qm74 6204 9 assure assure VB cord-015021-pol2qm74 6204 10 the the DT cord-015021-pol2qm74 6204 11 absence absence NN cord-015021-pol2qm74 6204 12 of of IN cord-015021-pol2qm74 6204 13 imbalance imbalance NN cord-015021-pol2qm74 6204 14 between between IN cord-015021-pol2qm74 6204 15 treatment treatment NN cord-015021-pol2qm74 6204 16 and and CC cord-015021-pol2qm74 6204 17 control control NN cord-015021-pol2qm74 6204 18 groups group NNS cord-015021-pol2qm74 6204 19 with with IN cord-015021-pol2qm74 6204 20 regard regard NN cord-015021-pol2qm74 6204 21 to to IN cord-015021-pol2qm74 6204 22 inappropriate inappropriate JJ cord-015021-pol2qm74 6204 23 antibiotic antibiotic JJ cord-015021-pol2qm74 6204 24 therapy therapy NN cord-015021-pol2qm74 6204 25 , , , cord-015021-pol2qm74 6204 26 especially especially RB cord-015021-pol2qm74 6204 27 with with IN cord-015021-pol2qm74 6204 28 subgroup subgroup NN cord-015021-pol2qm74 6204 29 analysis analysis NN cord-015021-pol2qm74 6204 30 . . . cord-015021-pol2qm74 6205 1 Statistical statistical JJ cord-015021-pol2qm74 6205 2 manipulation manipulation NN cord-015021-pol2qm74 6205 3 to to TO cord-015021-pol2qm74 6205 4 correct correct VB cord-015021-pol2qm74 6205 5 for for IN cord-015021-pol2qm74 6205 6 any any DT cord-015021-pol2qm74 6205 7 imbalance imbalance NN cord-015021-pol2qm74 6205 8 is be VBZ cord-015021-pol2qm74 6205 9 appropriate appropriate JJ cord-015021-pol2qm74 6205 10 but but CC cord-015021-pol2qm74 6205 11 avoiding avoid VBG cord-015021-pol2qm74 6205 12 imbalance imbalance NN cord-015021-pol2qm74 6205 13 is be VBZ cord-015021-pol2qm74 6205 14 ideal ideal JJ cord-015021-pol2qm74 6205 15 . . . cord-015021-pol2qm74 6206 1 Selection selection NN cord-015021-pol2qm74 6206 2 of of IN cord-015021-pol2qm74 6206 3 antibiotics antibiotic NNS cord-015021-pol2qm74 6206 4 in in IN cord-015021-pol2qm74 6206 5 septic septic JJ cord-015021-pol2qm74 6206 6 patients patient NNS cord-015021-pol2qm74 6206 7 requires require VBZ cord-015021-pol2qm74 6206 8 such such JJ cord-015021-pol2qm74 6206 9 considerations consideration NNS cord-015021-pol2qm74 6206 10 as as IN cord-015021-pol2qm74 6206 11 clinical clinical JJ cord-015021-pol2qm74 6206 12 setting setting NN cord-015021-pol2qm74 6206 13 ( ( -LRB- cord-015021-pol2qm74 6206 14 history history NN cord-015021-pol2qm74 6206 15 , , , cord-015021-pol2qm74 6206 16 physical physical JJ cord-015021-pol2qm74 6206 17 examination examination NN cord-015021-pol2qm74 6206 18 and and CC cord-015021-pol2qm74 6206 19 underlying underlying JJ cord-015021-pol2qm74 6206 20 disease disease NN cord-015021-pol2qm74 6206 21 ) ) -RRB- cord-015021-pol2qm74 6206 22 , , , cord-015021-pol2qm74 6206 23 appropriate appropriate JJ cord-015021-pol2qm74 6206 24 laboratory laboratory NN cord-015021-pol2qm74 6206 25 tests test NNS cord-015021-pol2qm74 6206 26 ( ( -LRB- cord-015021-pol2qm74 6206 27 such such JJ cord-015021-pol2qm74 6206 28 as as IN cord-015021-pol2qm74 6206 29 gram gram NN cord-015021-pol2qm74 6206 30 stain stain NN cord-015021-pol2qm74 6206 31 ) ) -RRB- cord-015021-pol2qm74 6206 32 , , , cord-015021-pol2qm74 6206 33 identification identification NN cord-015021-pol2qm74 6206 34 of of IN cord-015021-pol2qm74 6206 35 source source NN cord-015021-pol2qm74 6206 36 and and CC cord-015021-pol2qm74 6206 37 associated associated JJ cord-015021-pol2qm74 6206 38 bacterial bacterial JJ cord-015021-pol2qm74 6206 39 flora flora NNS cord-015021-pol2qm74 6206 40 , , , cord-015021-pol2qm74 6206 41 antibiotic antibiotic JJ cord-015021-pol2qm74 6206 42 susceptibility susceptibility NN cord-015021-pol2qm74 6206 43 patterns pattern NNS cord-015021-pol2qm74 6206 44 for for IN cord-015021-pol2qm74 6206 45 that that DT cord-015021-pol2qm74 6206 46 hospital hospital NN cord-015021-pol2qm74 6206 47 and and CC cord-015021-pol2qm74 6206 48 likelihood likelihood NN cord-015021-pol2qm74 6206 49 of of IN cord-015021-pol2qm74 6206 50 resistant resistant JJ cord-015021-pol2qm74 6206 51 organisms organism NNS cord-015021-pol2qm74 6206 52 . . . cord-015021-pol2qm74 6207 1 Determination determination NN cord-015021-pol2qm74 6207 2 of of IN cord-015021-pol2qm74 6207 3 inappropriate inappropriate JJ cord-015021-pol2qm74 6207 4 antibiotic antibiotic JJ cord-015021-pol2qm74 6207 5 therapy therapy NN cord-015021-pol2qm74 6207 6 is be VBZ cord-015021-pol2qm74 6207 7 made make VBN cord-015021-pol2qm74 6207 8 retrospectively retrospectively RB cord-015021-pol2qm74 6207 9 after after IN cord-015021-pol2qm74 6207 10 culture culture NN cord-015021-pol2qm74 6207 11 results result NNS cord-015021-pol2qm74 6207 12 are be VBP cord-015021-pol2qm74 6207 13 available available JJ cord-015021-pol2qm74 6207 14 . . . cord-015021-pol2qm74 6208 1 In in IN cord-015021-pol2qm74 6208 2 some some DT cord-015021-pol2qm74 6208 3 circunmtances circunmtance NNS cord-015021-pol2qm74 6208 4 the the DT cord-015021-pol2qm74 6208 5 organism organism NN cord-015021-pol2qm74 6208 6 and and CC cord-015021-pol2qm74 6208 7 antibiotic antibiotic JJ cord-015021-pol2qm74 6208 8 sensitivities sensitivity NNS cord-015021-pol2qm74 6208 9 can can MD cord-015021-pol2qm74 6208 10 not not RB cord-015021-pol2qm74 6208 11 be be VB cord-015021-pol2qm74 6208 12 predicted predict VBN cord-015021-pol2qm74 6208 13 , , , cord-015021-pol2qm74 6208 14 while while IN cord-015021-pol2qm74 6208 15 in in IN cord-015021-pol2qm74 6208 16 others other NNS cord-015021-pol2qm74 6208 17 it -PRON- PRP cord-015021-pol2qm74 6208 18 can can MD cord-015021-pol2qm74 6208 19 . . . cord-015021-pol2qm74 6209 1 Leibovici Leibovici NNP cord-015021-pol2qm74 6209 2 et et IN cord-015021-pol2qm74 6209 3 al al NNP cord-015021-pol2qm74 6209 4 identified identify VBD cord-015021-pol2qm74 6209 5 hospital hospital NN cord-015021-pol2qm74 6209 6 acquired acquire VBD cord-015021-pol2qm74 6209 7 infection infection NN cord-015021-pol2qm74 6209 8 , , , cord-015021-pol2qm74 6209 9 antibiotic antibiotic JJ cord-015021-pol2qm74 6209 10 treatment treatment NN cord-015021-pol2qm74 6209 11 before before IN cord-015021-pol2qm74 6209 12 a a DT cord-015021-pol2qm74 6209 13 bacteremic bacteremic JJ cord-015021-pol2qm74 6209 14 episode episode NN cord-015021-pol2qm74 6209 15 , , , cord-015021-pol2qm74 6209 16 endotracheal endotracheal NN cord-015021-pol2qm74 6209 17 intubetion intubetion NN cord-015021-pol2qm74 6209 18 and and CC cord-015021-pol2qm74 6209 19 thermal thermal JJ cord-015021-pol2qm74 6209 20 trauma trauma NN cord-015021-pol2qm74 6209 21 as as IN cord-015021-pol2qm74 6209 22 independent independent JJ cord-015021-pol2qm74 6209 23 variables variable NNS cord-015021-pol2qm74 6209 24 which which WDT cord-015021-pol2qm74 6209 25 predicted predict VBD cord-015021-pol2qm74 6209 26 isolation isolation NN cord-015021-pol2qm74 6209 27 of of IN cord-015021-pol2qm74 6209 28 a a DT cord-015021-pol2qm74 6209 29 multiresistant multiresistant JJ cord-015021-pol2qm74 6209 30 organism organism NN cord-015021-pol2qm74 6209 31 . . . cord-015021-pol2qm74 6210 1 The the DT cord-015021-pol2qm74 6210 2 same same JJ cord-015021-pol2qm74 6210 3 authors author NNS cord-015021-pol2qm74 6210 4 developed develop VBD cord-015021-pol2qm74 6210 5 a a DT cord-015021-pol2qm74 6210 6 predictive predictive JJ cord-015021-pol2qm74 6210 7 index index NN cord-015021-pol2qm74 6210 8 for for IN cord-015021-pol2qm74 6210 9 resistant resistant JJ cord-015021-pol2qm74 6210 10 organisms organism NNS cord-015021-pol2qm74 6210 11 , , , cord-015021-pol2qm74 6210 12 which which WDT cord-015021-pol2qm74 6210 13 when when WRB cord-015021-pol2qm74 6210 14 compared compare VBN cord-015021-pol2qm74 6210 15 to to IN cord-015021-pol2qm74 6210 16 prescriptions prescription NNS cord-015021-pol2qm74 6210 17 of of IN cord-015021-pol2qm74 6210 18 attending attend VBG cord-015021-pol2qm74 6210 19 physicians physician NNS cord-015021-pol2qm74 6210 20 , , , cord-015021-pol2qm74 6210 21 improved improve VBD cord-015021-pol2qm74 6210 22 antibiotic antibiotic JJ cord-015021-pol2qm74 6210 23 selection selection NN cord-015021-pol2qm74 6210 24 in in IN cord-015021-pol2qm74 6210 25 critically critically RB cord-015021-pol2qm74 6210 26 ill ill JJ cord-015021-pol2qm74 6210 27 patients patient NNS cord-015021-pol2qm74 6210 28 . . . cord-015021-pol2qm74 6211 1 Including include VBG cord-015021-pol2qm74 6211 2 a a DT cord-015021-pol2qm74 6211 3 standard standard JJ cord-015021-pol2qm74 6211 4 antibiotic antibiotic JJ cord-015021-pol2qm74 6211 5 regimen regimen NN cord-015021-pol2qm74 6211 6 for for IN cord-015021-pol2qm74 6211 7 all all DT cord-015021-pol2qm74 6211 8 septic septic JJ cord-015021-pol2qm74 6211 9 patients patient NNS cord-015021-pol2qm74 6211 10 in in IN cord-015021-pol2qm74 6211 11 a a DT cord-015021-pol2qm74 6211 12 clinical clinical JJ cord-015021-pol2qm74 6211 13 trial trial NN cord-015021-pol2qm74 6211 14 is be VBZ cord-015021-pol2qm74 6211 15 impractical impractical JJ cord-015021-pol2qm74 6211 16 . . . cord-015021-pol2qm74 6212 1 There there EX cord-015021-pol2qm74 6212 2 is be VBZ cord-015021-pol2qm74 6212 3 too too RB cord-015021-pol2qm74 6212 4 much much JJ cord-015021-pol2qm74 6212 5 interhopsital interhopsital JJ cord-015021-pol2qm74 6212 6 variability variability NN cord-015021-pol2qm74 6212 7 in in IN cord-015021-pol2qm74 6212 8 flora flora NNS cord-015021-pol2qm74 6212 9 and and CC cord-015021-pol2qm74 6212 10 antibiotic antibiotic JJ cord-015021-pol2qm74 6212 11 susceptibility susceptibility NN cord-015021-pol2qm74 6212 12 . . . cord-015021-pol2qm74 6213 1 In in IN cord-015021-pol2qm74 6213 2 addition addition NN cord-015021-pol2qm74 6213 3 , , , cord-015021-pol2qm74 6213 4 the the DT cord-015021-pol2qm74 6213 5 aggressive aggressive JJ cord-015021-pol2qm74 6213 6 broad broad JJ cord-015021-pol2qm74 6213 7 spectrum spectrum NN cord-015021-pol2qm74 6213 8 coverage coverage NN cord-015021-pol2qm74 6213 9 necessary necessary JJ cord-015021-pol2qm74 6213 10 for for IN cord-015021-pol2qm74 6213 11 some some DT cord-015021-pol2qm74 6213 12 patients patient NNS cord-015021-pol2qm74 6213 13 is be VBZ cord-015021-pol2qm74 6213 14 inappropriate inappropriate JJ cord-015021-pol2qm74 6213 15 for for IN cord-015021-pol2qm74 6213 16 others other NNS cord-015021-pol2qm74 6213 17 . . . cord-015021-pol2qm74 6214 1 A a DT cord-015021-pol2qm74 6214 2 protocol protocol NN cord-015021-pol2qm74 6214 3 which which WDT cord-015021-pol2qm74 6214 4 guides guide VBZ cord-015021-pol2qm74 6214 5 a a DT cord-015021-pol2qm74 6214 6 prescribing prescribe VBG cord-015021-pol2qm74 6214 7 physician physician NN cord-015021-pol2qm74 6214 8 through through IN cord-015021-pol2qm74 6214 9 a a DT cord-015021-pol2qm74 6214 10 logical logical JJ cord-015021-pol2qm74 6214 11 chain chain NN cord-015021-pol2qm74 6214 12 of of IN cord-015021-pol2qm74 6214 13 reasoning reasoning NN cord-015021-pol2qm74 6214 14 might may MD cord-015021-pol2qm74 6214 15 improve improve VB cord-015021-pol2qm74 6214 16 antibiotic antibiotic JJ cord-015021-pol2qm74 6214 17 selection selection NN cord-015021-pol2qm74 6214 18 in in IN cord-015021-pol2qm74 6214 19 critically critically RB cord-015021-pol2qm74 6214 20 ill ill JJ cord-015021-pol2qm74 6214 21 patients patient NNS cord-015021-pol2qm74 6214 22 and and CC cord-015021-pol2qm74 6214 23 could could MD cord-015021-pol2qm74 6214 24 be be VB cord-015021-pol2qm74 6214 25 included include VBN cord-015021-pol2qm74 6214 26 in in IN cord-015021-pol2qm74 6214 27 the the DT cord-015021-pol2qm74 6214 28 design design NN cord-015021-pol2qm74 6214 29 of of IN cord-015021-pol2qm74 6214 30 a a DT cord-015021-pol2qm74 6214 31 clinical clinical JJ cord-015021-pol2qm74 6214 32 trial trial NN cord-015021-pol2qm74 6214 33 in in IN cord-015021-pol2qm74 6214 34 sepsis sepsis NN cord-015021-pol2qm74 6214 35 . . . cord-015021-pol2qm74 6215 1 Although although IN cord-015021-pol2qm74 6215 2 this this DT cord-015021-pol2qm74 6215 3 approach approach NN cord-015021-pol2qm74 6215 4 might may MD cord-015021-pol2qm74 6215 5 minimize minimize VB cord-015021-pol2qm74 6215 6 potential potential NN cord-015021-pol2qm74 6215 7 for for IN cord-015021-pol2qm74 6215 8 maldistribution maldistribution NN cord-015021-pol2qm74 6215 9 of of IN cord-015021-pol2qm74 6215 10 inappropriate inappropriate JJ cord-015021-pol2qm74 6215 11 antimierobial antimierobial JJ cord-015021-pol2qm74 6215 12 therapy therapy NN cord-015021-pol2qm74 6215 13 , , , cord-015021-pol2qm74 6215 14 it -PRON- PRP cord-015021-pol2qm74 6215 15 would would MD cord-015021-pol2qm74 6215 16 likely likely RB cord-015021-pol2qm74 6215 17 create create VB cord-015021-pol2qm74 6215 18 multiple multiple JJ cord-015021-pol2qm74 6215 19 problem problem NN cord-015021-pol2qm74 6215 20 areas area NNS cord-015021-pol2qm74 6215 21 . . . cord-015021-pol2qm74 6216 1 Will Will MD cord-015021-pol2qm74 6216 2 the the DT cord-015021-pol2qm74 6216 3 patient patient NN cord-015021-pol2qm74 6216 4 's 's POS cord-015021-pol2qm74 6216 5 physicians physician NNS cord-015021-pol2qm74 6216 6 agree agree VBP cord-015021-pol2qm74 6216 7 to to IN cord-015021-pol2qm74 6216 8 the the DT cord-015021-pol2qm74 6216 9 protocol protocol NN cord-015021-pol2qm74 6216 10 choice choice NN cord-015021-pol2qm74 6216 11 ? ? . cord-015021-pol2qm74 6217 1 What what WP cord-015021-pol2qm74 6217 2 is be VBZ cord-015021-pol2qm74 6217 3 the the DT cord-015021-pol2qm74 6217 4 availability availability NN cord-015021-pol2qm74 6217 5 of of IN cord-015021-pol2qm74 6217 6 speciftc speciftc NNP cord-015021-pol2qm74 6217 7 antibiotics antibiotic NNS cord-015021-pol2qm74 6217 8 at at IN cord-015021-pol2qm74 6217 9 a a DT cord-015021-pol2qm74 6217 10 participating participate VBG cord-015021-pol2qm74 6217 11 hospital hospital NN cord-015021-pol2qm74 6217 12 ? ? . cord-015021-pol2qm74 6218 1 What what WP cord-015021-pol2qm74 6218 2 is be VBZ cord-015021-pol2qm74 6218 3 the the DT cord-015021-pol2qm74 6218 4 aplpiieability aplpiieability NN cord-015021-pol2qm74 6218 5 of of IN cord-015021-pol2qm74 6218 6 study study NN cord-015021-pol2qm74 6218 7 results result NNS cord-015021-pol2qm74 6218 8 in in IN cord-015021-pol2qm74 6218 9 typical typical JJ cord-015021-pol2qm74 6218 10 clinical clinical JJ cord-015021-pol2qm74 6218 11 situations situation NNS cord-015021-pol2qm74 6218 12 ? ? . cord-015021-pol2qm74 6219 1 If if IN cord-015021-pol2qm74 6219 2 there there EX cord-015021-pol2qm74 6219 3 is be VBZ cord-015021-pol2qm74 6219 4 agreement agreement NN cord-015021-pol2qm74 6219 5 that that IN cord-015021-pol2qm74 6219 6 thin thin JJ cord-015021-pol2qm74 6219 7 is be VBZ cord-015021-pol2qm74 6219 8 an an DT cord-015021-pol2qm74 6219 9 appropriate appropriate JJ cord-015021-pol2qm74 6219 10 antibiotic antibiotic JJ cord-015021-pol2qm74 6219 11 protocol protocol NN cord-015021-pol2qm74 6219 12 , , , cord-015021-pol2qm74 6219 13 should should MD cord-015021-pol2qm74 6219 14 it -PRON- PRP cord-015021-pol2qm74 6219 15 not not RB cord-015021-pol2qm74 6219 16 be be VB cord-015021-pol2qm74 6219 17 used use VBN cord-015021-pol2qm74 6219 18 in in IN cord-015021-pol2qm74 6219 19 all all DT cord-015021-pol2qm74 6219 20 seriously seriously RB cord-015021-pol2qm74 6219 21 ill ill JJ cord-015021-pol2qm74 6219 22 septic septic JJ cord-015021-pol2qm74 6219 23 patients patient NNS cord-015021-pol2qm74 6219 24 in in IN cord-015021-pol2qm74 6219 25 the the DT cord-015021-pol2qm74 6219 26 hospital hospital NN cord-015021-pol2qm74 6219 27 ? ? . cord-015021-pol2qm74 6220 1 In in IN cord-015021-pol2qm74 6220 2 other other JJ cord-015021-pol2qm74 6220 3 conditions condition NNS cord-015021-pol2qm74 6220 4 such such JJ cord-015021-pol2qm74 6220 5 as as IN cord-015021-pol2qm74 6220 6 ARDS ARDS NNP cord-015021-pol2qm74 6220 7 , , , cord-015021-pol2qm74 6220 8 the the DT cord-015021-pol2qm74 6220 9 success success NN cord-015021-pol2qm74 6220 10 of of IN cord-015021-pol2qm74 6220 11 protocol protocol NN cord-015021-pol2qm74 6220 12 therapy therapy NN cord-015021-pol2qm74 6220 13 is be VBZ cord-015021-pol2qm74 6220 14 dependent dependent JJ cord-015021-pol2qm74 6220 15 upon upon IN cord-015021-pol2qm74 6220 16 measurable measurable JJ cord-015021-pol2qm74 6220 17 goals goal NNS cord-015021-pol2qm74 6220 18 such such JJ cord-015021-pol2qm74 6220 19 as as IN cord-015021-pol2qm74 6220 20 Pao Pao NNP cord-015021-pol2qm74 6220 21 2 2 CD cord-015021-pol2qm74 6220 22 and and CC cord-015021-pol2qm74 6220 23 highest high JJS cord-015021-pol2qm74 6220 24 plateau plateau NN cord-015021-pol2qm74 6220 25 pressure pressure NN cord-015021-pol2qm74 6220 26 , , , cord-015021-pol2qm74 6220 27 while while IN cord-015021-pol2qm74 6220 28 measurable measurable JJ cord-015021-pol2qm74 6220 29 goals goal NNS cord-015021-pol2qm74 6220 30 are be VBP cord-015021-pol2qm74 6220 31 not not RB cord-015021-pol2qm74 6220 32 as as RB cord-015021-pol2qm74 6220 33 clear clear JJ cord-015021-pol2qm74 6220 34 in in IN cord-015021-pol2qm74 6220 35 choosing choose VBG cord-015021-pol2qm74 6220 36 antibiotics antibiotic NNS cord-015021-pol2qm74 6220 37 . . . cord-015021-pol2qm74 6221 1 Based base VBN cord-015021-pol2qm74 6221 2 on on IN cord-015021-pol2qm74 6221 3 the the DT cord-015021-pol2qm74 6221 4 above above JJ cord-015021-pol2qm74 6221 5 confounding confounding JJ cord-015021-pol2qm74 6221 6 issues issue NNS cord-015021-pol2qm74 6221 7 , , , cord-015021-pol2qm74 6221 8 a a DT cord-015021-pol2qm74 6221 9 complex complex JJ cord-015021-pol2qm74 6221 10 and and CC cord-015021-pol2qm74 6221 11 extensive extensive JJ cord-015021-pol2qm74 6221 12 algorithm algorithm NN cord-015021-pol2qm74 6221 13 covering cover VBG cord-015021-pol2qm74 6221 14 many many JJ cord-015021-pol2qm74 6221 15 potential potential JJ cord-015021-pol2qm74 6221 16 possibilities possibility NNS cord-015021-pol2qm74 6221 17 of of IN cord-015021-pol2qm74 6221 18 error error NN cord-015021-pol2qm74 6221 19 and and CC cord-015021-pol2qm74 6221 20 specific specific JJ cord-015021-pol2qm74 6221 21 antibiotics antibiotic NNS cord-015021-pol2qm74 6221 22 seems seem VBZ cord-015021-pol2qm74 6221 23 impractical impractical JJ cord-015021-pol2qm74 6221 24 ; ; : cord-015021-pol2qm74 6221 25 however however RB cord-015021-pol2qm74 6221 26 , , , cord-015021-pol2qm74 6221 27 an an DT cord-015021-pol2qm74 6221 28 algorithm algorithm NN cord-015021-pol2qm74 6221 29 focusing focus VBG cord-015021-pol2qm74 6221 30 on on IN cord-015021-pol2qm74 6221 31 three three CD cord-015021-pol2qm74 6221 32 to to TO cord-015021-pol2qm74 6221 33 four four CD cord-015021-pol2qm74 6221 34 major major JJ cord-015021-pol2qm74 6221 35 common common JJ cord-015021-pol2qm74 6221 36 errors error NNS cord-015021-pol2qm74 6221 37 in in IN cord-015021-pol2qm74 6221 38 antibiotic antibiotic JJ cord-015021-pol2qm74 6221 39 selection selection NN cord-015021-pol2qm74 6221 40 and and CC cord-015021-pol2qm74 6221 41 dealing deal VBG cord-015021-pol2qm74 6221 42 with with IN cord-015021-pol2qm74 6221 43 classes class NNS cord-015021-pol2qm74 6221 44 of of IN cord-015021-pol2qm74 6221 45 antibiotics antibiotic NNS cord-015021-pol2qm74 6221 46 is be VBZ cord-015021-pol2qm74 6221 47 plausible plausible JJ cord-015021-pol2qm74 6221 48 for for IN cord-015021-pol2qm74 6221 49 inclusion inclusion NN cord-015021-pol2qm74 6221 50 in in IN cord-015021-pol2qm74 6221 51 sepsis sepsis NN cord-015021-pol2qm74 6221 52 clinical clinical JJ cord-015021-pol2qm74 6221 53 trials trial NNS cord-015021-pol2qm74 6221 54 . . . cord-015021-pol2qm74 6222 1 In in IN cord-015021-pol2qm74 6222 2 this this DT cord-015021-pol2qm74 6222 3 session session NN cord-015021-pol2qm74 6222 4 we -PRON- PRP cord-015021-pol2qm74 6222 5 will will MD cord-015021-pol2qm74 6222 6 attempt attempt VB cord-015021-pol2qm74 6222 7 to to TO cord-015021-pol2qm74 6222 8 outline outline VB cord-015021-pol2qm74 6222 9 the the DT cord-015021-pol2qm74 6222 10 methodology methodology NN cord-015021-pol2qm74 6222 11 of of IN cord-015021-pol2qm74 6222 12 such such PDT cord-015021-pol2qm74 6222 13 a a DT cord-015021-pol2qm74 6222 14 future future JJ cord-015021-pol2qm74 6222 15 study study NN cord-015021-pol2qm74 6222 16 , , , cord-015021-pol2qm74 6222 17 emphasizing emphasize VBG cord-015021-pol2qm74 6222 18 the the DT cord-015021-pol2qm74 6222 19 immense immense JJ cord-015021-pol2qm74 6222 20 difficulties difficulty NNS cord-015021-pol2qm74 6222 21 involved involve VBN cord-015021-pol2qm74 6222 22 in in IN cord-015021-pol2qm74 6222 23 its -PRON- PRP$ cord-015021-pol2qm74 6222 24 proper proper JJ cord-015021-pol2qm74 6222 25 conduction conduction NN cord-015021-pol2qm74 6222 26 including include VBG cord-015021-pol2qm74 6222 27 : : : cord-015021-pol2qm74 6222 28 design design NN cord-015021-pol2qm74 6222 29 , , , cord-015021-pol2qm74 6222 30 selection selection NN cord-015021-pol2qm74 6222 31 of of IN cord-015021-pol2qm74 6222 32 patients patient NNS cord-015021-pol2qm74 6222 33 , , , cord-015021-pol2qm74 6222 34 surgical surgical JJ cord-015021-pol2qm74 6222 35 considerations consideration NNS cord-015021-pol2qm74 6222 36 , , , cord-015021-pol2qm74 6222 37 supportive supportive JJ cord-015021-pol2qm74 6222 38 treatment treatment NN cord-015021-pol2qm74 6222 39 , , , cord-015021-pol2qm74 6222 40 the the DT cord-015021-pol2qm74 6222 41 " " `` cord-015021-pol2qm74 6222 42 human human JJ cord-015021-pol2qm74 6222 43 factor factor NN cord-015021-pol2qm74 6222 44 " " '' cord-015021-pol2qm74 6222 45 and and CC cord-015021-pol2qm74 6222 46 ~nd ~nd NNP cord-015021-pol2qm74 6222 47 points point NNS cord-015021-pol2qm74 6222 48 . . . cord-015021-pol2qm74 6223 1 Only only RB cord-015021-pol2qm74 6223 2 a a DT cord-015021-pol2qm74 6223 3 close close JJ cord-015021-pol2qm74 6223 4 cooperation cooperation NN cord-015021-pol2qm74 6223 5 between between IN cord-015021-pol2qm74 6223 6 a a DT cord-015021-pol2qm74 6223 7 few few JJ cord-015021-pol2qm74 6223 8 dedicated dedicated JJ cord-015021-pol2qm74 6223 9 surgeons surgeon NNS cord-015021-pol2qm74 6223 10 , , , cord-015021-pol2qm74 6223 11 obsessively obsessively RB cord-015021-pol2qm74 6223 12 studying study VBG cord-015021-pol2qm74 6223 13 a a DT cord-015021-pol2qm74 6223 14 large large JJ cord-015021-pol2qm74 6223 15 number number NN cord-015021-pol2qm74 6223 16 of of IN cord-015021-pol2qm74 6223 17 well well RB cord-015021-pol2qm74 6223 18 selected selected JJ cord-015021-pol2qm74 6223 19 and and CC cord-015021-pol2qm74 6223 20 stratified stratified JJ cord-015021-pol2qm74 6223 21 patients patient NNS cord-015021-pol2qm74 6223 22 over over IN cord-015021-pol2qm74 6223 23 years year NNS cord-015021-pol2qm74 6223 24 , , , cord-015021-pol2qm74 6223 25 could could MD cord-015021-pol2qm74 6223 26 make make VB cord-015021-pol2qm74 6223 27 such such PDT cord-015021-pol2qm74 6223 28 a a DT cord-015021-pol2qm74 6223 29 study study NN cord-015021-pol2qm74 6223 30 possible possible JJ cord-015021-pol2qm74 6223 31 . . . cord-015021-pol2qm74 6224 1 Algorithmis Algorithmis NNP cord-015021-pol2qm74 6224 2 have have VBP cord-015021-pol2qm74 6224 3 frequently frequently RB cord-015021-pol2qm74 6224 4 been be VBN cord-015021-pol2qm74 6224 5 mistaken mistaken JJ cord-015021-pol2qm74 6224 6 for for IN cord-015021-pol2qm74 6224 7 the the DT cord-015021-pol2qm74 6224 8 graphic graphic JJ cord-015021-pol2qm74 6224 9 format format NN cord-015021-pol2qm74 6224 10 in in IN cord-015021-pol2qm74 6224 11 which which WDT cord-015021-pol2qm74 6224 12 they -PRON- PRP cord-015021-pol2qm74 6224 13 are be VBP cord-015021-pol2qm74 6224 14 presented present VBN cord-015021-pol2qm74 6224 15 . . . cord-015021-pol2qm74 6225 1 However however RB cord-015021-pol2qm74 6225 2 , , , cord-015021-pol2qm74 6225 3 an an DT cord-015021-pol2qm74 6225 4 algorithm algorithm NN cord-015021-pol2qm74 6225 5 is be VBZ cord-015021-pol2qm74 6225 6 neither neither CC cord-015021-pol2qm74 6225 7 a a DT cord-015021-pol2qm74 6225 8 flow flow NN cord-015021-pol2qm74 6225 9 chart chart NN cord-015021-pol2qm74 6225 10 nor nor CC cord-015021-pol2qm74 6225 11 a a DT cord-015021-pol2qm74 6225 12 list list NN cord-015021-pol2qm74 6225 13 of of IN cord-015021-pol2qm74 6225 14 instructions instruction NNS cord-015021-pol2qm74 6225 15 ; ; : cord-015021-pol2qm74 6225 16 it -PRON- PRP cord-015021-pol2qm74 6225 17 is be VBZ cord-015021-pol2qm74 6225 18 a a DT cord-015021-pol2qm74 6225 19 step step NN cord-015021-pol2qm74 6225 20 - - HYPH cord-015021-pol2qm74 6225 21 by by IN cord-015021-pol2qm74 6225 22 - - HYPH cord-015021-pol2qm74 6225 23 step step NN cord-015021-pol2qm74 6225 24 approach approach NN cord-015021-pol2qm74 6225 25 to to IN cord-015021-pol2qm74 6225 26 solving solve VBG cord-015021-pol2qm74 6225 27 a a DT cord-015021-pol2qm74 6225 28 problem problem NN cord-015021-pol2qm74 6225 29 . . . cord-015021-pol2qm74 6226 1 Likewise likewise RB cord-015021-pol2qm74 6226 2 , , , cord-015021-pol2qm74 6226 3 a a DT cord-015021-pol2qm74 6226 4 clinical clinical JJ cord-015021-pol2qm74 6226 5 algorithm algorithm NN cord-015021-pol2qm74 6226 6 is be VBZ cord-015021-pol2qm74 6226 7 a a DT cord-015021-pol2qm74 6226 8 step step NN cord-015021-pol2qm74 6226 9 - - HYPH cord-015021-pol2qm74 6226 10 by by IN cord-015021-pol2qm74 6226 11 - - HYPH cord-015021-pol2qm74 6226 12 step step NN cord-015021-pol2qm74 6226 13 approach approach NN cord-015021-pol2qm74 6226 14 to to IN cord-015021-pol2qm74 6226 15 solving solve VBG cord-015021-pol2qm74 6226 16 a a DT cord-015021-pol2qm74 6226 17 clinical clinical JJ cord-015021-pol2qm74 6226 18 problem problem NN cord-015021-pol2qm74 6226 19 . . . cord-015021-pol2qm74 6227 1 CAs CAs NNP cord-015021-pol2qm74 6227 2 are be VBP cord-015021-pol2qm74 6227 3 deterministic deterministic JJ cord-015021-pol2qm74 6227 4 , , , cord-015021-pol2qm74 6227 5 which which WDT cord-015021-pol2qm74 6227 6 does do VBZ cord-015021-pol2qm74 6227 7 not not RB cord-015021-pol2qm74 6227 8 mean mean VB cord-015021-pol2qm74 6227 9 that that IN cord-015021-pol2qm74 6227 10 they -PRON- PRP cord-015021-pol2qm74 6227 11 are be VBP cord-015021-pol2qm74 6227 12 rigid rigid JJ cord-015021-pol2qm74 6227 13 . . . cord-015021-pol2qm74 6228 1 They -PRON- PRP cord-015021-pol2qm74 6228 2 are be VBP cord-015021-pol2qm74 6228 3 practical practical JJ cord-015021-pol2qm74 6228 4 rather rather RB cord-015021-pol2qm74 6228 5 than than IN cord-015021-pol2qm74 6228 6 mathematical mathematical JJ cord-015021-pol2qm74 6228 7 algorithms algorithm NNS cord-015021-pol2qm74 6228 8 , , , cord-015021-pol2qm74 6228 9 that that IN cord-015021-pol2qm74 6228 10 tan tan NNP cord-015021-pol2qm74 6228 11 be be VB cord-015021-pol2qm74 6228 12 used use VBN cord-015021-pol2qm74 6228 13 only only RB cord-015021-pol2qm74 6228 14 with with IN cord-015021-pol2qm74 6228 15 clinical clinical JJ cord-015021-pol2qm74 6228 16 judgment judgment NN cord-015021-pol2qm74 6228 17 , , , cord-015021-pol2qm74 6228 18 and and CC cord-015021-pol2qm74 6228 19 must must MD cord-015021-pol2qm74 6228 20 be be VB cord-015021-pol2qm74 6228 21 tailored tailor VBN cord-015021-pol2qm74 6228 22 to to IN cord-015021-pol2qm74 6228 23 each each DT cord-015021-pol2qm74 6228 24 patient patient NN cord-015021-pol2qm74 6228 25 . . . cord-015021-pol2qm74 6229 1 There there EX cord-015021-pol2qm74 6229 2 are be VBP cord-015021-pol2qm74 6229 3 a a DT cord-015021-pol2qm74 6229 4 number number NN cord-015021-pol2qm74 6229 5 of of IN cord-015021-pol2qm74 6229 6 types type NNS cord-015021-pol2qm74 6229 7 of of IN cord-015021-pol2qm74 6229 8 , , , cord-015021-pol2qm74 6229 9 or or CC cord-015021-pol2qm74 6229 10 uses use VBZ cord-015021-pol2qm74 6229 11 for for IN cord-015021-pol2qm74 6229 12 , , , cord-015021-pol2qm74 6229 13 CAs CAs NNP cord-015021-pol2qm74 6229 14 that that WDT cord-015021-pol2qm74 6229 15 can can MD cord-015021-pol2qm74 6229 16 improve improve VB cord-015021-pol2qm74 6229 17 sepsis sepsis NN cord-015021-pol2qm74 6229 18 management management NN cord-015021-pol2qm74 6229 19 , , , cord-015021-pol2qm74 6229 20 including include VBG cord-015021-pol2qm74 6229 21 : : : cord-015021-pol2qm74 6229 22 diagnostic diagnostic JJ cord-015021-pol2qm74 6229 23 or or CC cord-015021-pol2qm74 6229 24 severity severity NN cord-015021-pol2qm74 6229 25 scorm scorm NNP cord-015021-pol2qm74 6229 26 CAs CAs NNP cord-015021-pol2qm74 6229 27 , , , cord-015021-pol2qm74 6229 28 a a DT cord-015021-pol2qm74 6229 29 management management NN cord-015021-pol2qm74 6229 30 CA CA NNP cord-015021-pol2qm74 6229 31 for for IN cord-015021-pol2qm74 6229 32 managing manage VBG cord-015021-pol2qm74 6229 33 sepsis sepsis NN cord-015021-pol2qm74 6229 34 constructed construct VBN cord-015021-pol2qm74 6229 35 according accord VBG cord-015021-pol2qm74 6229 36 to to IN cord-015021-pol2qm74 6229 37 recently recently RB cord-015021-pol2qm74 6229 38 published publish VBN cord-015021-pol2qm74 6229 39 standards standard NNS cord-015021-pol2qm74 6229 40 for for IN cord-015021-pol2qm74 6229 41 use use NN cord-015021-pol2qm74 6229 42 in in IN cord-015021-pol2qm74 6229 43 teaching teaching NN cord-015021-pol2qm74 6229 44 research research NN cord-015021-pol2qm74 6229 45 protocol protocol NN cord-015021-pol2qm74 6229 46 algorithms algorithm NNS cord-015021-pol2qm74 6229 47 that that WDT cord-015021-pol2qm74 6229 48 must must MD cord-015021-pol2qm74 6229 49 be be VB cord-015021-pol2qm74 6229 50 used use VBN cord-015021-pol2qm74 6229 51 to to TO cord-015021-pol2qm74 6229 52 collect collect VB cord-015021-pol2qm74 6229 53 data datum NNS cord-015021-pol2qm74 6229 54 or or CC cord-015021-pol2qm74 6229 55 guide guide NN cord-015021-pol2qm74 6229 56 implementation implementation NN cord-015021-pol2qm74 6229 57 of of IN cord-015021-pol2qm74 6229 58 a a DT cord-015021-pol2qm74 6229 59 clinical clinical JJ cord-015021-pol2qm74 6229 60 trial trial NN cord-015021-pol2qm74 6229 61 aimed aim VBN cord-015021-pol2qm74 6229 62 at at IN cord-015021-pol2qm74 6229 63 validating validate VBG cord-015021-pol2qm74 6229 64 one one CD cord-015021-pol2qm74 6229 65 or or CC cord-015021-pol2qm74 6229 66 more more JJR cord-015021-pol2qm74 6229 67 dicisions dicision NNS cord-015021-pol2qm74 6229 68 in in IN cord-015021-pol2qm74 6229 69 the the DT cord-015021-pol2qm74 6229 70 management management NN cord-015021-pol2qm74 6229 71 CA CA NNP cord-015021-pol2qm74 6229 72 ; ; : cord-015021-pol2qm74 6229 73 finally finally RB cord-015021-pol2qm74 6229 74 , , , cord-015021-pol2qm74 6229 75 protocol protocol NN cord-015021-pol2qm74 6229 76 - - HYPH cord-015021-pol2qm74 6229 77 style style NN cord-015021-pol2qm74 6229 78 CAs ca NNS cord-015021-pol2qm74 6229 79 drawn draw VBN cord-015021-pol2qm74 6229 80 from from IN cord-015021-pol2qm74 6229 81 the the DT cord-015021-pol2qm74 6229 82 management management NN cord-015021-pol2qm74 6229 83 CA CA NNP cord-015021-pol2qm74 6229 84 and and CC cord-015021-pol2qm74 6229 85 should should MD cord-015021-pol2qm74 6229 86 be be VB cord-015021-pol2qm74 6229 87 validated validate VBN cord-015021-pol2qm74 6229 88 using use VBG cord-015021-pol2qm74 6229 89 matching match VBG cord-015021-pol2qm74 6229 90 outcome outcome NN cord-015021-pol2qm74 6229 91 studies study NNS cord-015021-pol2qm74 6229 92 . . . cord-015021-pol2qm74 6229 93 _SP cord-015021-pol2qm74 6230 1 Organisational organisational JJ cord-015021-pol2qm74 6230 2 problems problem NNS cord-015021-pol2qm74 6230 3 peculiar peculiar JJ cord-015021-pol2qm74 6230 4 to to IN cord-015021-pol2qm74 6230 5 multicentre multicentre NNP cord-015021-pol2qm74 6230 6 trials trial NNS cord-015021-pol2qm74 6231 1 The the DT cord-015021-pol2qm74 6231 2 organisation organisation NN cord-015021-pol2qm74 6231 3 of of IN cord-015021-pol2qm74 6231 4 any any DT cord-015021-pol2qm74 6231 5 randomised randomised JJ cord-015021-pol2qm74 6231 6 clinical clinical JJ cord-015021-pol2qm74 6231 7 trial trial NN cord-015021-pol2qm74 6231 8 is be VBZ cord-015021-pol2qm74 6231 9 fraught fraught JJ cord-015021-pol2qm74 6231 10 with with IN cord-015021-pol2qm74 6231 11 difficulties difficulty NNS cord-015021-pol2qm74 6231 12 , , , cord-015021-pol2qm74 6231 13 and and CC cord-015021-pol2qm74 6231 14 that that DT cord-015021-pol2qm74 6231 15 of of IN cord-015021-pol2qm74 6231 16 a a DT cord-015021-pol2qm74 6231 17 multicentre multicentre NNP cord-015021-pol2qm74 6231 18 trial trial NN cord-015021-pol2qm74 6231 19 particularly particularly RB cord-015021-pol2qm74 6231 20 so so RB cord-015021-pol2qm74 6231 21 . . . cord-015021-pol2qm74 6232 1 There there EX cord-015021-pol2qm74 6232 2 are be VBP cord-015021-pol2qm74 6232 3 problems problem NNS cord-015021-pol2qm74 6232 4 associated associate VBN cord-015021-pol2qm74 6232 5 not not RB cord-015021-pol2qm74 6232 6 only only RB cord-015021-pol2qm74 6232 7 with with IN cord-015021-pol2qm74 6232 8 the the DT cord-015021-pol2qm74 6232 9 principles principle NNS cord-015021-pol2qm74 6232 10 on on IN cord-015021-pol2qm74 6232 11 which which WDT cord-015021-pol2qm74 6232 12 the the DT cord-015021-pol2qm74 6232 13 investigation investigation NN cord-015021-pol2qm74 6232 14 is be VBZ cord-015021-pol2qm74 6232 15 based base VBN cord-015021-pol2qm74 6232 16 but but CC cord-015021-pol2qm74 6232 17 also also RB cord-015021-pol2qm74 6232 18 with with IN cord-015021-pol2qm74 6232 19 the the DT cord-015021-pol2qm74 6232 20 detailed detailed JJ cord-015021-pol2qm74 6232 21 organisation organisation NN cord-015021-pol2qm74 6232 22 and and CC cord-015021-pol2qm74 6232 23 analysis analysis NN cord-015021-pol2qm74 6232 24 . . . cord-015021-pol2qm74 6233 1 Are be VBP cord-015021-pol2qm74 6233 2 all all PDT cord-015021-pol2qm74 6233 3 the the DT cord-015021-pol2qm74 6233 4 participants participant NNS cord-015021-pol2qm74 6233 5 truly truly RB cord-015021-pol2qm74 6233 6 unbiased unbiased JJ cord-015021-pol2qm74 6233 7 about about IN cord-015021-pol2qm74 6233 8 the the DT cord-015021-pol2qm74 6233 9 relative relative JJ cord-015021-pol2qm74 6233 10 merits merit NNS cord-015021-pol2qm74 6233 11 of of IN cord-015021-pol2qm74 6233 12 the the DT cord-015021-pol2qm74 6233 13 regimens regimen NNS cord-015021-pol2qm74 6233 14 being be VBG cord-015021-pol2qm74 6233 15 studied study VBN cord-015021-pol2qm74 6233 16 ? ? . cord-015021-pol2qm74 6234 1 Is be VBZ cord-015021-pol2qm74 6234 2 like like IN cord-015021-pol2qm74 6234 3 being be VBG cord-015021-pol2qm74 6234 4 compared compare VBN cord-015021-pol2qm74 6234 5 with with IN cord-015021-pol2qm74 6234 6 like like UH cord-015021-pol2qm74 6234 7 -are -are : cord-015021-pol2qm74 6234 8 all all PDT cord-015021-pol2qm74 6234 9 the the DT cord-015021-pol2qm74 6234 10 end end NN cord-015021-pol2qm74 6234 11 points point NNS cord-015021-pol2qm74 6234 12 and and CC cord-015021-pol2qm74 6234 13 the the DT cord-015021-pol2qm74 6234 14 standards standard NNS cord-015021-pol2qm74 6234 15 for for IN cord-015021-pol2qm74 6234 16 measuring measure VBG cord-015021-pol2qm74 6234 17 them -PRON- PRP cord-015021-pol2qm74 6234 18 clearly clearly RB cord-015021-pol2qm74 6234 19 defined define VBN cord-015021-pol2qm74 6234 20 so so IN cord-015021-pol2qm74 6234 21 that that IN cord-015021-pol2qm74 6234 22 they -PRON- PRP cord-015021-pol2qm74 6234 23 can can MD cord-015021-pol2qm74 6234 24 not not RB cord-015021-pol2qm74 6234 25 be be VB cord-015021-pol2qm74 6234 26 misunderstood misunderstand VBN cord-015021-pol2qm74 6234 27 ? ? . cord-015021-pol2qm74 6235 1 Are be VBP cord-015021-pol2qm74 6235 2 all all DT cord-015021-pol2qm74 6235 3 eligible eligible JJ cord-015021-pol2qm74 6235 4 patients patient NNS cord-015021-pol2qm74 6235 5 being be VBG cord-015021-pol2qm74 6235 6 studied study VBN cord-015021-pol2qm74 6235 7 , , , cord-015021-pol2qm74 6235 8 and and CC cord-015021-pol2qm74 6235 9 their -PRON- PRP$ cord-015021-pol2qm74 6235 10 results result NNS cord-015021-pol2qm74 6235 11 reported report VBN cord-015021-pol2qm74 6235 12 ? ? . cord-015021-pol2qm74 6236 1 Is be VBZ cord-015021-pol2qm74 6236 2 truly truly RB cord-015021-pol2qm74 6236 3 informed informed JJ cord-015021-pol2qm74 6236 4 consent consent NN cord-015021-pol2qm74 6236 5 being be VBG cord-015021-pol2qm74 6236 6 sought seek VBN cord-015021-pol2qm74 6236 7 that that WDT cord-015021-pol2qm74 6236 8 will will MD cord-015021-pol2qm74 6236 9 satisfy satisfy VB cord-015021-pol2qm74 6236 10 not not RB cord-015021-pol2qm74 6236 11 only only RB cord-015021-pol2qm74 6236 12 the the DT cord-015021-pol2qm74 6236 13 patient patient NN cord-015021-pol2qm74 6236 14 's 's POS cord-015021-pol2qm74 6236 15 right right NN cord-015021-pol2qm74 6236 16 to to TO cord-015021-pol2qm74 6236 17 choose choose VB cord-015021-pol2qm74 6236 18 what what WP cord-015021-pol2qm74 6236 19 happens happen VBZ cord-015021-pol2qm74 6236 20 to to IN cord-015021-pol2qm74 6236 21 him -PRON- PRP cord-015021-pol2qm74 6236 22 , , , cord-015021-pol2qm74 6236 23 but but CC cord-015021-pol2qm74 6236 24 also also RB cord-015021-pol2qm74 6236 25 the the DT cord-015021-pol2qm74 6236 26 law law NN cord-015021-pol2qm74 6236 27 of of IN cord-015021-pol2qm74 6236 28 the the DT cord-015021-pol2qm74 6236 29 land land NN cord-015021-pol2qm74 6236 30 ? ? . cord-015021-pol2qm74 6237 1 And and CC cord-015021-pol2qm74 6237 2 , , , cord-015021-pol2qm74 6237 3 finally finally RB cord-015021-pol2qm74 6237 4 , , , cord-015021-pol2qm74 6237 5 how how WRB cord-015021-pol2qm74 6237 6 can can MD cord-015021-pol2qm74 6237 7 the the DT cord-015021-pol2qm74 6237 8 participants participant NNS cord-015021-pol2qm74 6237 9 be be VB cord-015021-pol2qm74 6237 10 sure sure JJ cord-015021-pol2qm74 6237 11 that that IN cord-015021-pol2qm74 6237 12 the the DT cord-015021-pol2qm74 6237 13 trial trial NN cord-015021-pol2qm74 6237 14 will will MD cord-015021-pol2qm74 6237 15 be be VB cord-015021-pol2qm74 6237 16 stopped stop VBN cord-015021-pol2qm74 6237 17 at at IN cord-015021-pol2qm74 6237 18 the the DT cord-015021-pol2qm74 6237 19 right right JJ cord-015021-pol2qm74 6237 20 time time NN cord-015021-pol2qm74 6237 21 , , , cord-015021-pol2qm74 6237 22 to to TO cord-015021-pol2qm74 6237 23 ensure ensure VB cord-015021-pol2qm74 6237 24 that that IN cord-015021-pol2qm74 6237 25 no no DT cord-015021-pol2qm74 6237 26 treatment treatment NN cord-015021-pol2qm74 6237 27 is be VBZ cord-015021-pol2qm74 6237 28 given give VBN cord-015021-pol2qm74 6237 29 to to IN cord-015021-pol2qm74 6237 30 any any DT cord-015021-pol2qm74 6237 31 patient patient NN cord-015021-pol2qm74 6237 32 that that WDT cord-015021-pol2qm74 6237 33 might may MD cord-015021-pol2qm74 6237 34 be be VB cord-015021-pol2qm74 6237 35 harmful harmful JJ cord-015021-pol2qm74 6237 36 ? ? . cord-015021-pol2qm74 6238 1 These these DT cord-015021-pol2qm74 6238 2 questions question NNS cord-015021-pol2qm74 6238 3 may may MD cord-015021-pol2qm74 6238 4 seem seem VB cord-015021-pol2qm74 6238 5 insoluble insoluble JJ cord-015021-pol2qm74 6238 6 , , , cord-015021-pol2qm74 6238 7 but but CC cord-015021-pol2qm74 6238 8 until until IN cord-015021-pol2qm74 6238 9 we -PRON- PRP cord-015021-pol2qm74 6238 10 tackle tackle VBP cord-015021-pol2qm74 6238 11 them -PRON- PRP cord-015021-pol2qm74 6238 12 we -PRON- PRP cord-015021-pol2qm74 6238 13 shall shall MD cord-015021-pol2qm74 6238 14 never never RB cord-015021-pol2qm74 6238 15 be be VB cord-015021-pol2qm74 6238 16 certain certain JJ cord-015021-pol2qm74 6238 17 . . . cord-015021-pol2qm74 6239 1 Dr. Dr. NNP cord-015021-pol2qm74 6240 1 M. M. NNP cord-015021-pol2qm74 6240 2 Ev Ev NNP cord-015021-pol2qm74 6240 3 ~ ~ NNP cord-015021-pol2qm74 6240 4 s s NNP cord-015021-pol2qm74 6240 5 , , , cord-015021-pol2qm74 6240 6 Scar Scar NNP cord-015021-pol2qm74 6240 7 ~ ~ NFP cord-015021-pol2qm74 6240 8 mu~ mu~ NN cord-015021-pol2qm74 6240 9 Hospital Hospital NNP cord-015021-pol2qm74 6240 10 , , , cord-015021-pol2qm74 6240 11 Scarborough Scarborough NNP cord-015021-pol2qm74 6240 12 , , , cord-015021-pol2qm74 6240 13 NonhYo NonhYo NNP cord-015021-pol2qm74 6240 14 ~ ~ NFP cord-015021-pol2qm74 6240 15 s~ s~ CD cord-015021-pol2qm74 6240 16 Y0126QL Y0126QL NNP cord-015021-pol2qm74 6240 17 , , , cord-015021-pol2qm74 6241 1 U.K. U.K. NNP cord-015021-pol2qm74 6241 2 Increasing increase VBG cord-015021-pol2qm74 6241 3 knowledge knowledge NN cord-015021-pol2qm74 6241 4 of of IN cord-015021-pol2qm74 6241 5 the the DT cord-015021-pol2qm74 6241 6 pathogenesis pathogenesis NN cord-015021-pol2qm74 6241 7 of of IN cord-015021-pol2qm74 6241 8 sepsis sepsis NN cord-015021-pol2qm74 6241 9 and and CC cord-015021-pol2qm74 6241 10 septic septic JJ cord-015021-pol2qm74 6241 11 shock shock NN cord-015021-pol2qm74 6241 12 has have VBZ cord-015021-pol2qm74 6241 13 led lead VBN cord-015021-pol2qm74 6241 14 to to IN cord-015021-pol2qm74 6241 15 the the DT cord-015021-pol2qm74 6241 16 development development NN cord-015021-pol2qm74 6241 17 of of IN cord-015021-pol2qm74 6241 18 many many JJ cord-015021-pol2qm74 6241 19 new new JJ cord-015021-pol2qm74 6241 20 therapies therapy NNS cord-015021-pol2qm74 6241 21 and and CC cord-015021-pol2qm74 6241 22 technologies technology NNS cord-015021-pol2qm74 6241 23 capable capable JJ cord-015021-pol2qm74 6241 24 of of IN cord-015021-pol2qm74 6241 25 preventing prevent VBG cord-015021-pol2qm74 6241 26 , , , cord-015021-pol2qm74 6241 27 blocking block VBG cord-015021-pol2qm74 6241 28 or or CC cord-015021-pol2qm74 6241 29 even even RB cord-015021-pol2qm74 6241 30 reversing reverse VBG cord-015021-pol2qm74 6241 31 the the DT cord-015021-pol2qm74 6241 32 deleterious deleterious JJ cord-015021-pol2qm74 6241 33 cycle cycle NN cord-015021-pol2qm74 6241 34 of of IN cord-015021-pol2qm74 6241 35 events event NNS cord-015021-pol2qm74 6241 36 . . . cord-015021-pol2qm74 6242 1 Recent recent JJ cord-015021-pol2qm74 6242 2 results result NNS cord-015021-pol2qm74 6242 3 of of IN cord-015021-pol2qm74 6242 4 subsequent subsequent JJ cord-015021-pol2qm74 6242 5 multicenter multicenter JJ cord-015021-pol2qm74 6242 6 trials trial NNS cord-015021-pol2qm74 6242 7 testing test VBG cord-015021-pol2qm74 6242 8 some some DT cord-015021-pol2qm74 6242 9 novel novel JJ cord-015021-pol2qm74 6242 10 therapeutic therapeutic JJ cord-015021-pol2qm74 6242 11 drugs drug NNS cord-015021-pol2qm74 6242 12 , , , cord-015021-pol2qm74 6242 13 however however RB cord-015021-pol2qm74 6242 14 , , , cord-015021-pol2qm74 6242 15 did do VBD cord-015021-pol2qm74 6242 16 not not RB cord-015021-pol2qm74 6242 17 confirm confirm VB cord-015021-pol2qm74 6242 18 the the DT cord-015021-pol2qm74 6242 19 promising promising NN cord-015021-pol2qm74 6242 20 sometimes sometimes RB cord-015021-pol2qm74 6242 21 overwhelming overwhelming JJ cord-015021-pol2qm74 6242 22 effects effect NNS cord-015021-pol2qm74 6242 23 obtained obtain VBN cord-015021-pol2qm74 6242 24 experimentally experimentally RB cord-015021-pol2qm74 6242 25 . . . cord-015021-pol2qm74 6243 1 It -PRON- PRP cord-015021-pol2qm74 6243 2 is be VBZ cord-015021-pol2qm74 6243 3 postulated postulate VBN cord-015021-pol2qm74 6243 4 that that IN cord-015021-pol2qm74 6243 5 this this DT cord-015021-pol2qm74 6243 6 is be VBZ cord-015021-pol2qm74 6243 7 largely largely RB cord-015021-pol2qm74 6243 8 due due JJ cord-015021-pol2qm74 6243 9 to to IN cord-015021-pol2qm74 6243 10 inappropriate inappropriate JJ cord-015021-pol2qm74 6243 11 design design NN cord-015021-pol2qm74 6243 12 and and CC cord-015021-pol2qm74 6243 13 conduct conduct NN cord-015021-pol2qm74 6243 14 of of IN cord-015021-pol2qm74 6243 15 multicenter multicenter JJ cord-015021-pol2qm74 6243 16 trials trial NNS cord-015021-pol2qm74 6243 17 as as IN cord-015021-pol2qm74 6243 18 currently currently RB cord-015021-pol2qm74 6243 19 performed perform VBN cord-015021-pol2qm74 6243 20 . . . cord-015021-pol2qm74 6244 1 One one CD cord-015021-pol2qm74 6244 2 of of IN cord-015021-pol2qm74 6244 3 the the DT cord-015021-pol2qm74 6244 4 shortcomings shortcoming NNS cord-015021-pol2qm74 6244 5 emphasized emphasize VBN cord-015021-pol2qm74 6244 6 in in IN cord-015021-pol2qm74 6244 7 this this DT cord-015021-pol2qm74 6244 8 paper paper NN cord-015021-pol2qm74 6244 9 is be VBZ cord-015021-pol2qm74 6244 10 the the DT cord-015021-pol2qm74 6244 11 " " `` cord-015021-pol2qm74 6244 12 treatment treatment NN cord-015021-pol2qm74 6244 13 mix mix NN cord-015021-pol2qm74 6244 14 " " '' cord-015021-pol2qm74 6244 15 problem problem NN cord-015021-pol2qm74 6244 16 . . . cord-015021-pol2qm74 6245 1 Multicenter multicenter JJ cord-015021-pol2qm74 6245 2 trials trial NNS cord-015021-pol2qm74 6245 3 in in IN cord-015021-pol2qm74 6245 4 sepsis sepsis NN cord-015021-pol2qm74 6245 5 are be VBP cord-015021-pol2qm74 6245 6 performed perform VBN cord-015021-pol2qm74 6245 7 because because IN cord-015021-pol2qm74 6245 8 no no DT cord-015021-pol2qm74 6245 9 single single JJ cord-015021-pol2qm74 6245 10 center center NN cord-015021-pol2qm74 6245 11 is be VBZ cord-015021-pol2qm74 6245 12 able able JJ cord-015021-pol2qm74 6245 13 to to TO cord-015021-pol2qm74 6245 14 recruit recruit VB cord-015021-pol2qm74 6245 15 the the DT cord-015021-pol2qm74 6245 16 necessary necessary JJ cord-015021-pol2qm74 6245 17 number number NN cord-015021-pol2qm74 6245 18 of of IN cord-015021-pol2qm74 6245 19 eligible eligible JJ cord-015021-pol2qm74 6245 20 subjects subject NNS cord-015021-pol2qm74 6245 21 within within IN cord-015021-pol2qm74 6245 22 a a DT cord-015021-pol2qm74 6245 23 reasonable reasonable JJ cord-015021-pol2qm74 6245 24 time time NN cord-015021-pol2qm74 6245 25 . . . cord-015021-pol2qm74 6246 1 Each each DT cord-015021-pol2qm74 6246 2 single single JJ cord-015021-pol2qm74 6246 3 center center NN cord-015021-pol2qm74 6246 4 ( ( -LRB- cord-015021-pol2qm74 6246 5 ICU ICU NNP cord-015021-pol2qm74 6246 6 ) ) -RRB- cord-015021-pol2qm74 6246 7 has have VBZ cord-015021-pol2qm74 6246 8 its -PRON- PRP$ cord-015021-pol2qm74 6246 9 own own JJ cord-015021-pol2qm74 6246 10 individual individual JJ cord-015021-pol2qm74 6246 11 policy policy NN cord-015021-pol2qm74 6246 12 which which WDT cord-015021-pol2qm74 6246 13 can can MD cord-015021-pol2qm74 6246 14 not not RB cord-015021-pol2qm74 6246 15 be be VB cord-015021-pol2qm74 6246 16 standardized standardize VBN cord-015021-pol2qm74 6246 17 for for IN cord-015021-pol2qm74 6246 18 the the DT cord-015021-pol2qm74 6246 19 trial trial NN cord-015021-pol2qm74 6246 20 ( ( -LRB- cord-015021-pol2qm74 6246 21 treatment treatment NN cord-015021-pol2qm74 6246 22 mix mix NN cord-015021-pol2qm74 6246 23 ) ) -RRB- cord-015021-pol2qm74 6246 24 . . . cord-015021-pol2qm74 6247 1 Even even RB cord-015021-pol2qm74 6247 2 if if IN cord-015021-pol2qm74 6247 3 we -PRON- PRP cord-015021-pol2qm74 6247 4 ascribe ascribe VBP cord-015021-pol2qm74 6247 5 that that IN cord-015021-pol2qm74 6247 6 each each DT cord-015021-pol2qm74 6247 7 ICU ICU NNP cord-015021-pol2qm74 6247 8 did do VBD cord-015021-pol2qm74 6247 9 the the DT cord-015021-pol2qm74 6247 10 " " `` cord-015021-pol2qm74 6247 11 best good JJS cord-015021-pol2qm74 6247 12 " " '' cord-015021-pol2qm74 6247 13 for for IN cord-015021-pol2qm74 6247 14 their -PRON- PRP$ cord-015021-pol2qm74 6247 15 patients patient NNS cord-015021-pol2qm74 6247 16 , , , cord-015021-pol2qm74 6247 17 it -PRON- PRP cord-015021-pol2qm74 6247 18 is be VBZ cord-015021-pol2qm74 6247 19 highly highly RB cord-015021-pol2qm74 6247 20 probable probable JJ cord-015021-pol2qm74 6247 21 that that IN cord-015021-pol2qm74 6247 22 the the DT cord-015021-pol2qm74 6247 23 outcome outcome NN cord-015021-pol2qm74 6247 24 differs differ VBZ cord-015021-pol2qm74 6247 25 between between IN cord-015021-pol2qm74 6247 26 the the DT cord-015021-pol2qm74 6247 27 ICUs ICUs NNP cord-015021-pol2qm74 6247 28 . . . cord-015021-pol2qm74 6248 1 This this DT cord-015021-pol2qm74 6248 2 translates translate VBZ cord-015021-pol2qm74 6248 3 to to IN cord-015021-pol2qm74 6248 4 the the DT cord-015021-pol2qm74 6248 5 effect effect NN cord-015021-pol2qm74 6248 6 of of IN cord-015021-pol2qm74 6248 7 the the DT cord-015021-pol2qm74 6248 8 new new JJ cord-015021-pol2qm74 6248 9 therapy therapy NN cord-015021-pol2qm74 6248 10 under under IN cord-015021-pol2qm74 6248 11 investigation investigation NN cord-015021-pol2qm74 6248 12 . . . cord-015021-pol2qm74 6248 13 ] ] -RRB- cord-015021-pol2qm74 6249 1 t t NNP cord-015021-pol2qm74 6249 2 is be VBZ cord-015021-pol2qm74 6249 3 therefore therefore RB cord-015021-pol2qm74 6249 4 worthwhile worthwhile JJ cord-015021-pol2qm74 6249 5 to to TO cord-015021-pol2qm74 6249 6 consider consider VB cord-015021-pol2qm74 6249 7 that that IN cord-015021-pol2qm74 6249 8 ICUs ICUs NNP cord-015021-pol2qm74 6249 9 must must MD cord-015021-pol2qm74 6249 10 first first RB cord-015021-pol2qm74 6249 11 demonstrate demonstrate VB cord-015021-pol2qm74 6249 12 a a DT cord-015021-pol2qm74 6249 13 certain certain JJ cord-015021-pol2qm74 6249 14 standard standard NN cord-015021-pol2qm74 6249 15 based base VBN cord-015021-pol2qm74 6249 16 on on IN cord-015021-pol2qm74 6249 17 the the DT cord-015021-pol2qm74 6249 18 patients patient NNS cord-015021-pol2qm74 6249 19 ' ' POS cord-015021-pol2qm74 6249 20 outcome outcome NN cord-015021-pol2qm74 6249 21 ( ( -LRB- cord-015021-pol2qm74 6249 22 audit audit NN cord-015021-pol2qm74 6249 23 ) ) -RRB- cord-015021-pol2qm74 6249 24 before before IN cord-015021-pol2qm74 6249 25 becoming become VBG cord-015021-pol2qm74 6249 26 accepted accept VBN cord-015021-pol2qm74 6249 27 as as IN cord-015021-pol2qm74 6249 28 a a DT cord-015021-pol2qm74 6249 29 participating participate VBG cord-015021-pol2qm74 6249 30 center center NN cord-015021-pol2qm74 6249 31 . . . cord-015021-pol2qm74 6250 1 This this DT cord-015021-pol2qm74 6250 2 prerequisite prerequisite NN cord-015021-pol2qm74 6250 3 ensures ensure VBZ cord-015021-pol2qm74 6250 4 comparable comparable JJ cord-015021-pol2qm74 6250 5 quality quality NN cord-015021-pol2qm74 6250 6 between between IN cord-015021-pol2qm74 6250 7 participating participate VBG cord-015021-pol2qm74 6250 8 centers center NNS cord-015021-pol2qm74 6250 9 , , , cord-015021-pol2qm74 6250 10 led lead VBD cord-015021-pol2qm74 6250 11 to to IN cord-015021-pol2qm74 6250 12 the the DT cord-015021-pol2qm74 6250 13 reduction reduction NN cord-015021-pol2qm74 6250 14 of of IN cord-015021-pol2qm74 6250 15 " " `` cord-015021-pol2qm74 6250 16 noise noise NN cord-015021-pol2qm74 6250 17 level level NN cord-015021-pol2qm74 6250 18 " " '' cord-015021-pol2qm74 6250 19 and and CC cord-015021-pol2qm74 6250 20 increases increase VBZ cord-015021-pol2qm74 6250 21 the the DT cord-015021-pol2qm74 6250 22 probability probability NN cord-015021-pol2qm74 6250 23 of of IN cord-015021-pol2qm74 6250 24 positive positive JJ cord-015021-pol2qm74 6250 25 study study NN cord-015021-pol2qm74 6250 26 results result NNS cord-015021-pol2qm74 6250 27 . . . cord-015021-pol2qm74 6251 1 The the DT cord-015021-pol2qm74 6251 2 RIYADH RIYADH NNP cord-015021-pol2qm74 6251 3 - - HYPH cord-015021-pol2qm74 6251 4 ICU ICU NNP cord-015021-pol2qm74 6251 5 program program NN cord-015021-pol2qm74 6251 6 based base VBN cord-015021-pol2qm74 6251 7 on on IN cord-015021-pol2qm74 6251 8 standard standard JJ cord-015021-pol2qm74 6251 9 mortality mortality NN cord-015021-pol2qm74 6251 10 ratios ratio NNS cord-015021-pol2qm74 6251 11 is be VBZ cord-015021-pol2qm74 6251 12 recommended recommend VBN cord-015021-pol2qm74 6251 13 as as IN cord-015021-pol2qm74 6251 14 an an DT cord-015021-pol2qm74 6251 15 audit audit NN cord-015021-pol2qm74 6251 16 instrument instrument NN cord-015021-pol2qm74 6251 17 . . . cord-015021-pol2qm74 6252 1 During during IN cord-015021-pol2qm74 6252 2 the the DT cord-015021-pol2qm74 6252 3 last last JJ cord-015021-pol2qm74 6252 4 decade decade NN cord-015021-pol2qm74 6252 5 most most RBS cord-015021-pol2qm74 6252 6 clinical clinical JJ cord-015021-pol2qm74 6252 7 trials trial NNS cord-015021-pol2qm74 6252 8 of of IN cord-015021-pol2qm74 6252 9 potential potential JJ cord-015021-pol2qm74 6252 10 therapeutic therapeutic JJ cord-015021-pol2qm74 6252 11 agents agent NNS cord-015021-pol2qm74 6252 12 in in IN cord-015021-pol2qm74 6252 13 systemic systemic JJ cord-015021-pol2qm74 6252 14 sepsis sepsis NN cord-015021-pol2qm74 6252 15 have have VBP cord-015021-pol2qm74 6252 16 failed fail VBN cord-015021-pol2qm74 6252 17 to to TO cord-015021-pol2qm74 6252 18 demonstrate demonstrate VB cord-015021-pol2qm74 6252 19 benefit benefit NN cord-015021-pol2qm74 6252 20 from from IN cord-015021-pol2qm74 6252 21 the the DT cord-015021-pol2qm74 6252 22 drug drug NN cord-015021-pol2qm74 6252 23 under under IN cord-015021-pol2qm74 6252 24 study study NN cord-015021-pol2qm74 6252 25 . . . cord-015021-pol2qm74 6253 1 Although although IN cord-015021-pol2qm74 6253 2 in in IN cord-015021-pol2qm74 6253 3 many many JJ cord-015021-pol2qm74 6253 4 instances instance NNS cord-015021-pol2qm74 6253 5 it -PRON- PRP cord-015021-pol2qm74 6253 6 is be VBZ cord-015021-pol2qm74 6253 7 entirely entirely RB cord-015021-pol2qm74 6253 8 possible possible JJ cord-015021-pol2qm74 6253 9 that that IN cord-015021-pol2qm74 6253 10 the the DT cord-015021-pol2qm74 6253 11 agent agent NN cord-015021-pol2qm74 6253 12 in in IN cord-015021-pol2qm74 6253 13 question question NN cord-015021-pol2qm74 6253 14 does do VBZ cord-015021-pol2qm74 6253 15 not not RB cord-015021-pol2qm74 6253 16 have have VB cord-015021-pol2qm74 6253 17 clinical clinical JJ cord-015021-pol2qm74 6253 18 efficacy efficacy NN cord-015021-pol2qm74 6253 19 , , , cord-015021-pol2qm74 6253 20 an an DT cord-015021-pol2qm74 6253 21 equally equally RB cord-015021-pol2qm74 6253 22 plausible plausible JJ cord-015021-pol2qm74 6253 23 explanation explanation NN cord-015021-pol2qm74 6253 24 for for IN cord-015021-pol2qm74 6253 25 the the DT cord-015021-pol2qm74 6253 26 multitude multitude NN cord-015021-pol2qm74 6253 27 of of IN cord-015021-pol2qm74 6253 28 negative negative JJ cord-015021-pol2qm74 6253 29 results result NNS cord-015021-pol2qm74 6253 30 is be VBZ cord-015021-pol2qm74 6253 31 that that IN cord-015021-pol2qm74 6253 32 the the DT cord-015021-pol2qm74 6253 33 studies study NNS cord-015021-pol2qm74 6253 34 were be VBD cord-015021-pol2qm74 6253 35 improperly improperly RB cord-015021-pol2qm74 6253 36 designed design VBN cord-015021-pol2qm74 6253 37 and and CC cord-015021-pol2qm74 6253 38 thus thus RB cord-015021-pol2qm74 6253 39 could could MD cord-015021-pol2qm74 6253 40 not not RB cord-015021-pol2qm74 6253 41 show show VB cord-015021-pol2qm74 6253 42 therapeutic therapeutic JJ cord-015021-pol2qm74 6253 43 benefit benefit NN cord-015021-pol2qm74 6253 44 , , , cord-015021-pol2qm74 6253 45 if if IN cord-015021-pol2qm74 6253 46 it -PRON- PRP cord-015021-pol2qm74 6253 47 existed exist VBD cord-015021-pol2qm74 6253 48 . . . cord-015021-pol2qm74 6254 1 Problems problem NNS cord-015021-pol2qm74 6254 2 which which WDT cord-015021-pol2qm74 6254 3 have have VBP cord-015021-pol2qm74 6254 4 been be VBN cord-015021-pol2qm74 6254 5 identified identify VBN cord-015021-pol2qm74 6254 6 in in IN cord-015021-pol2qm74 6254 7 these these DT cord-015021-pol2qm74 6254 8 various various JJ cord-015021-pol2qm74 6254 9 trials trial NNS cord-015021-pol2qm74 6254 10 include include VBP cord-015021-pol2qm74 6254 11 inappropriate inappropriate JJ cord-015021-pol2qm74 6254 12 or or CC cord-015021-pol2qm74 6254 13 unrealistic unrealistic JJ cord-015021-pol2qm74 6254 14 definitions definition NNS cord-015021-pol2qm74 6254 15 of of IN cord-015021-pol2qm74 6254 16 response response NN cord-015021-pol2qm74 6254 17 to to IN cord-015021-pol2qm74 6254 18 the the DT cord-015021-pol2qm74 6254 19 drug drug NN cord-015021-pol2qm74 6254 20 ; ; , cord-015021-pol2qm74 6254 21 inadequate inadequate JJ cord-015021-pol2qm74 6254 22 sample sample NN cord-015021-pol2qm74 6254 23 size size NN cord-015021-pol2qm74 6254 24 , , , cord-015021-pol2qm74 6254 25 with with IN cord-015021-pol2qm74 6254 26 attendant attendant JJ cord-015021-pol2qm74 6254 27 insufficient insufficient JJ cord-015021-pol2qm74 6254 28 statistical statistical JJ cord-015021-pol2qm74 6254 29 power power NN cord-015021-pol2qm74 6254 30 to to TO cord-015021-pol2qm74 6254 31 demonstrate demonstrate VB cord-015021-pol2qm74 6254 32 a a DT cord-015021-pol2qm74 6254 33 difference difference NN cord-015021-pol2qm74 6254 34 , , , cord-015021-pol2qm74 6254 35 if if IN cord-015021-pol2qm74 6254 36 it -PRON- PRP cord-015021-pol2qm74 6254 37 existed exist VBD cord-015021-pol2qm74 6254 38 ; ; , cord-015021-pol2qm74 6254 39 insufficient insufficient JJ cord-015021-pol2qm74 6254 40 standardization standardization NN cord-015021-pol2qm74 6254 41 of of IN cord-015021-pol2qm74 6254 42 customary customary JJ cord-015021-pol2qm74 6254 43 therapeutic therapeutic JJ cord-015021-pol2qm74 6254 44 maneuvers maneuver NNS cord-015021-pol2qm74 6254 45 in in IN cord-015021-pol2qm74 6254 46 septic septic JJ cord-015021-pol2qm74 6254 47 patients patient NNS cord-015021-pol2qm74 6254 48 ; ; : cord-015021-pol2qm74 6254 49 imprecise imprecise JJ cord-015021-pol2qm74 6254 50 criteria criterion NNS cord-015021-pol2qm74 6254 51 for for IN cord-015021-pol2qm74 6254 52 patient patient JJ cord-015021-pol2qm74 6254 53 entry entry NN cord-015021-pol2qm74 6254 54 into into IN cord-015021-pol2qm74 6254 55 the the DT cord-015021-pol2qm74 6254 56 study study NN cord-015021-pol2qm74 6254 57 , , , cord-015021-pol2qm74 6254 58 which which WDT cord-015021-pol2qm74 6254 59 creates create VBZ cord-015021-pol2qm74 6254 60 unacceptable unacceptable JJ cord-015021-pol2qm74 6254 61 inhomogeneity inhomogeneity NN cord-015021-pol2qm74 6254 62 between between IN cord-015021-pol2qm74 6254 63 control control NN cord-015021-pol2qm74 6254 64 and and CC cord-015021-pol2qm74 6254 65 treatment treatment NN cord-015021-pol2qm74 6254 66 groups group NNS cord-015021-pol2qm74 6254 67 and and CC cord-015021-pol2qm74 6254 68 invites invite VBZ cord-015021-pol2qm74 6254 69 unjustified unjustified JJ cord-015021-pol2qm74 6254 70 post post JJ cord-015021-pol2qm74 6254 71 - - JJ cord-015021-pol2qm74 6254 72 study study JJ cord-015021-pol2qm74 6254 73 subgroup subgroup NN cord-015021-pol2qm74 6254 74 analysis analysis NN cord-015021-pol2qm74 6254 75 ; ; : cord-015021-pol2qm74 6254 76 the the DT cord-015021-pol2qm74 6254 77 lack lack NN cord-015021-pol2qm74 6254 78 of of IN cord-015021-pol2qm74 6254 79 a a DT cord-015021-pol2qm74 6254 80 formal formal JJ cord-015021-pol2qm74 6254 81 sequential sequential JJ cord-015021-pol2qm74 6254 82 monitoring monitoring NN cord-015021-pol2qm74 6254 83 procedure procedure NN cord-015021-pol2qm74 6254 84 for for IN cord-015021-pol2qm74 6254 85 interim interim JJ cord-015021-pol2qm74 6254 86 data datum NNS cord-015021-pol2qm74 6254 87 analysis analysis NN cord-015021-pol2qm74 6254 88 , , , cord-015021-pol2qm74 6254 89 which which WDT cord-015021-pol2qm74 6254 90 could could MD cord-015021-pol2qm74 6254 91 potentially potentially RB cord-015021-pol2qm74 6254 92 affect affect VB cord-015021-pol2qm74 6254 93 patient patient JJ cord-015021-pol2qm74 6254 94 safety safety NN cord-015021-pol2qm74 6254 95 ; ; : cord-015021-pol2qm74 6254 96 and and CC cord-015021-pol2qm74 6254 97 a a DT cord-015021-pol2qm74 6254 98 primary primary JJ cord-015021-pol2qm74 6254 99 analysis analysis NN cord-015021-pol2qm74 6254 100 of of IN cord-015021-pol2qm74 6254 101 study study NN cord-015021-pol2qm74 6254 102 results result NNS cord-015021-pol2qm74 6254 103 that that WDT cord-015021-pol2qm74 6254 104 excludes exclude VBZ cord-015021-pol2qm74 6254 105 protocol protocol NN cord-015021-pol2qm74 6254 106 deviants deviant NNS cord-015021-pol2qm74 6254 107 and and CC cord-015021-pol2qm74 6254 108 is be VBZ cord-015021-pol2qm74 6254 109 not not RB cord-015021-pol2qm74 6254 110 according accord VBG cord-015021-pol2qm74 6254 111 to to IN cord-015021-pol2qm74 6254 112 intent intent NN cord-015021-pol2qm74 6254 113 - - HYPH cord-015021-pol2qm74 6254 114 to to IN cord-015021-pol2qm74 6254 115 - - HYPH cord-015021-pol2qm74 6254 116 treat treat NN cord-015021-pol2qm74 6254 117 . . . cord-015021-pol2qm74 6255 1 These these DT cord-015021-pol2qm74 6255 2 and and CC cord-015021-pol2qm74 6255 3 other other JJ cord-015021-pol2qm74 6255 4 problems problem NNS cord-015021-pol2qm74 6255 5 have have VBP cord-015021-pol2qm74 6255 6 impacted impact VBN cord-015021-pol2qm74 6255 7 upon upon IN cord-015021-pol2qm74 6255 8 the the DT cord-015021-pol2qm74 6255 9 validity validity NN cord-015021-pol2qm74 6255 10 of of IN cord-015021-pol2qm74 6255 11 the the DT cord-015021-pol2qm74 6255 12 various various JJ cord-015021-pol2qm74 6255 13 trials trial NNS cord-015021-pol2qm74 6255 14 conducted conduct VBN cord-015021-pol2qm74 6255 15 to to IN cord-015021-pol2qm74 6255 16 date date NN cord-015021-pol2qm74 6255 17 and and CC cord-015021-pol2qm74 6255 18 may may MD cord-015021-pol2qm74 6255 19 well well RB cord-015021-pol2qm74 6255 20 have have VB cord-015021-pol2qm74 6255 21 prevented prevent VBN cord-015021-pol2qm74 6255 22 the the DT cord-015021-pol2qm74 6255 23 resolution resolution NN cord-015021-pol2qm74 6255 24 of of IN cord-015021-pol2qm74 6255 25 controversies controversy NNS cord-015021-pol2qm74 6255 26 surrounding surround VBG cord-015021-pol2qm74 6255 27 the the DT cord-015021-pol2qm74 6255 28 use use NN cord-015021-pol2qm74 6255 29 of of IN cord-015021-pol2qm74 6255 30 certain certain JJ cord-015021-pol2qm74 6255 31 agents agent NNS cord-015021-pol2qm74 6255 32 in in IN cord-015021-pol2qm74 6255 33 the the DT cord-015021-pol2qm74 6255 34 treatment treatment NN cord-015021-pol2qm74 6255 35 of of IN cord-015021-pol2qm74 6255 36 septic septic JJ cord-015021-pol2qm74 6255 37 patients patient NNS cord-015021-pol2qm74 6255 38 . . . cord-015021-pol2qm74 6256 1 The the DT cord-015021-pol2qm74 6256 2 complexity complexity NN cord-015021-pol2qm74 6256 3 of of IN cord-015021-pol2qm74 6256 4 bacterially bacterially RB cord-015021-pol2qm74 6256 5 - - HYPH cord-015021-pol2qm74 6256 6 induced induce VBN cord-015021-pol2qm74 6256 7 septic septic JJ cord-015021-pol2qm74 6256 8 shock shock NN cord-015021-pol2qm74 6256 9 involves involve VBZ cord-015021-pol2qm74 6256 10 a a DT cord-015021-pol2qm74 6256 11 cascade cascade NN cord-015021-pol2qm74 6256 12 of of IN cord-015021-pol2qm74 6256 13 events event NNS cord-015021-pol2qm74 6256 14 that that WDT cord-015021-pol2qm74 6256 15 evolve evolve VBP cord-015021-pol2qm74 6256 16 over over IN cord-015021-pol2qm74 6256 17 time time NN cord-015021-pol2qm74 6256 18 , , , cord-015021-pol2qm74 6256 19 beginning begin VBG cord-015021-pol2qm74 6256 20 with with IN cord-015021-pol2qm74 6256 21 the the DT cord-015021-pol2qm74 6256 22 proliferation proliferation NN cord-015021-pol2qm74 6256 23 of of IN cord-015021-pol2qm74 6256 24 offending offend VBG cord-015021-pol2qm74 6256 25 organisms organism NNS cord-015021-pol2qm74 6256 26 and and CC cord-015021-pol2qm74 6256 27 followed follow VBN cord-015021-pol2qm74 6256 28 by by IN cord-015021-pol2qm74 6256 29 the the DT cord-015021-pol2qm74 6256 30 release release NN cord-015021-pol2qm74 6256 31 of of IN cord-015021-pol2qm74 6256 32 toxic toxic JJ cord-015021-pol2qm74 6256 33 mediators mediator NNS cord-015021-pol2qm74 6256 34 from from IN cord-015021-pol2qm74 6256 35 the the DT cord-015021-pol2qm74 6256 36 bacteria bacteria NNS cord-015021-pol2qm74 6256 37 . . . cord-015021-pol2qm74 6257 1 Endotoxins endotoxin NNS cord-015021-pol2qm74 6257 2 [ [ -LRB- cord-015021-pol2qm74 6257 3 e.g. e.g. RB cord-015021-pol2qm74 6257 4 lipopolysaccharides lipopolysaccharides NNP cord-015021-pol2qm74 6257 5 ) ) -RRB- cord-015021-pol2qm74 6257 6 from from IN cord-015021-pol2qm74 6257 7 gram gram NN cord-015021-pol2qm74 6257 8 - - HYPH cord-015021-pol2qm74 6257 9 negative negative JJ cord-015021-pol2qm74 6257 10 bacteria bacteria NNS cord-015021-pol2qm74 6257 11 initiate initiate VBP cord-015021-pol2qm74 6257 12 septic septic JJ cord-015021-pol2qm74 6257 13 shock shock NN cord-015021-pol2qm74 6257 14 by by IN cord-015021-pol2qm74 6257 15 precipitating precipitate VBG cord-015021-pol2qm74 6257 16 a a DT cord-015021-pol2qm74 6257 17 systemic systemic JJ cord-015021-pol2qm74 6257 18 inflammatory inflammatory JJ cord-015021-pol2qm74 6257 19 response response NN cord-015021-pol2qm74 6257 20 syndrome syndrome NN cord-015021-pol2qm74 6257 21 ( ( -LRB- cord-015021-pol2qm74 6257 22 SIRS sirs UH cord-015021-pol2qm74 6257 23 ) ) -RRB- cord-015021-pol2qm74 6257 24 through through IN cord-015021-pol2qm74 6257 25 release release NN cord-015021-pol2qm74 6257 26 of of IN cord-015021-pol2qm74 6257 27 a a DT cord-015021-pol2qm74 6257 28 broad broad JJ cord-015021-pol2qm74 6257 29 spectrum spectrum NN cord-015021-pol2qm74 6257 30 of of IN cord-015021-pol2qm74 6257 31 hostderived hostderived JJ cord-015021-pol2qm74 6257 32 mediators mediator NNS cord-015021-pol2qm74 6257 33 . . . cord-015021-pol2qm74 6258 1 Over over IN cord-015021-pol2qm74 6258 2 the the DT cord-015021-pol2qm74 6258 3 last last JJ cord-015021-pol2qm74 6258 4 century century NN cord-015021-pol2qm74 6258 5 , , , cord-015021-pol2qm74 6258 6 hundreds hundred NNS cord-015021-pol2qm74 6258 7 of of IN cord-015021-pol2qm74 6258 8 these these DT cord-015021-pol2qm74 6258 9 endogenous endogenous JJ cord-015021-pol2qm74 6258 10 mediators mediator NNS cord-015021-pol2qm74 6258 11 have have VBP cord-015021-pol2qm74 6258 12 been be VBN cord-015021-pol2qm74 6258 13 proposed propose VBN cord-015021-pol2qm74 6258 14 to to TO cord-015021-pol2qm74 6258 15 serve serve VB cord-015021-pol2qm74 6258 16 as as IN cord-015021-pol2qm74 6258 17 pathophysiological pathophysiological JJ cord-015021-pol2qm74 6258 18 substances substance NNS cord-015021-pol2qm74 6258 19 in in IN cord-015021-pol2qm74 6258 20 this this DT cord-015021-pol2qm74 6258 21 " " `` cord-015021-pol2qm74 6258 22 alphabet alphabet NN cord-015021-pol2qm74 6258 23 soup soup NN cord-015021-pol2qm74 6258 24 " " '' cord-015021-pol2qm74 6258 25 of of IN cord-015021-pol2qm74 6258 26 cytokines cytokine NNS cord-015021-pol2qm74 6258 27 , , , cord-015021-pol2qm74 6258 28 eieosanoids eieosanoid NNS cord-015021-pol2qm74 6258 29 , , , cord-015021-pol2qm74 6258 30 biogenic biogenic JJ cord-015021-pol2qm74 6258 31 amines amine NNS cord-015021-pol2qm74 6258 32 , , , cord-015021-pol2qm74 6258 33 kinins kinin NNS cord-015021-pol2qm74 6258 34 , , , cord-015021-pol2qm74 6258 35 peptides peptide NNS cord-015021-pol2qm74 6258 36 , , , cord-015021-pol2qm74 6258 37 ions ion NNS cord-015021-pol2qm74 6258 38 and and CC cord-015021-pol2qm74 6258 39 hormones hormone NNS cord-015021-pol2qm74 6258 40 . . . cord-015021-pol2qm74 6259 1 An an DT cord-015021-pol2qm74 6259 2 evaluation evaluation NN cord-015021-pol2qm74 6259 3 of of IN cord-015021-pol2qm74 6259 4 the the DT cord-015021-pol2qm74 6259 5 literature literature NN cord-015021-pol2qm74 6259 6 on on IN cord-015021-pol2qm74 6259 7 septic septic JJ cord-015021-pol2qm74 6259 8 shock shock NN cord-015021-pol2qm74 6259 9 leaves leave VBZ cord-015021-pol2qm74 6259 10 the the DT cord-015021-pol2qm74 6259 11 investigator investigator NN cord-015021-pol2qm74 6259 12 with with IN cord-015021-pol2qm74 6259 13 a a DT cord-015021-pol2qm74 6259 14 sense sense NN cord-015021-pol2qm74 6259 15 that that IN cord-015021-pol2qm74 6259 16 , , , cord-015021-pol2qm74 6259 17 although although IN cord-015021-pol2qm74 6259 18 many many JJ cord-015021-pol2qm74 6259 19 pieces piece NNS cord-015021-pol2qm74 6259 20 of of IN cord-015021-pol2qm74 6259 21 the the DT cord-015021-pol2qm74 6259 22 septic septic JJ cord-015021-pol2qm74 6259 23 shock shock NN cord-015021-pol2qm74 6259 24 puzzle puzzle NN cord-015021-pol2qm74 6259 25 have have VBP cord-015021-pol2qm74 6259 26 been be VBN cord-015021-pol2qm74 6259 27 presented present VBN cord-015021-pol2qm74 6259 28 , , , cord-015021-pol2qm74 6259 29 no no DT cord-015021-pol2qm74 6259 30 clue clue NN cord-015021-pol2qm74 6259 31 was be VBD cord-015021-pol2qm74 6259 32 provided provide VBN cord-015021-pol2qm74 6259 33 to to TO cord-015021-pol2qm74 6259 34 indicate indicate VB cord-015021-pol2qm74 6259 35 how how WRB cord-015021-pol2qm74 6259 36 these these DT cord-015021-pol2qm74 6259 37 pieces piece NNS cord-015021-pol2qm74 6259 38 fit fit VBP cord-015021-pol2qm74 6259 39 together together RB cord-015021-pol2qm74 6259 40 , , . cord-015021-pol2qm74 6260 1 In in IN cord-015021-pol2qm74 6260 2 an an DT cord-015021-pol2qm74 6260 3 attempt attempt NN cord-015021-pol2qm74 6260 4 to to TO cord-015021-pol2qm74 6260 5 assess assess VB cord-015021-pol2qm74 6260 6 objectively objectively RB cord-015021-pol2qm74 6260 7 the the DT cord-015021-pol2qm74 6260 8 causal causal JJ cord-015021-pol2qm74 6260 9 role role NN cord-015021-pol2qm74 6260 10 of of IN cord-015021-pol2qm74 6260 11 individual individual JJ cord-015021-pol2qm74 6260 12 mediators mediator NNS cord-015021-pol2qm74 6260 13 , , , cord-015021-pol2qm74 6260 14 we -PRON- PRP cord-015021-pol2qm74 6260 15 recently recently RB cord-015021-pol2qm74 6260 16 completed complete VBD cord-015021-pol2qm74 6260 17 a a DT cord-015021-pol2qm74 6260 18 collective collective JJ cord-015021-pol2qm74 6260 19 meta meta NN cord-015021-pol2qm74 6260 20 - - HYPH cord-015021-pol2qm74 6260 21 analysis analysis NN cord-015021-pol2qm74 6260 22 of of IN cord-015021-pol2qm74 6260 23 24 24 CD cord-015021-pol2qm74 6260 24 mediators mediator NNS cord-015021-pol2qm74 6260 25 that that WDT cord-015021-pol2qm74 6260 26 were be VBD cord-015021-pol2qm74 6260 27 individually individually RB cord-015021-pol2qm74 6260 28 reviewed review VBN cord-015021-pol2qm74 6260 29 and and CC cord-015021-pol2qm74 6260 30 subjected subject VBN cord-015021-pol2qm74 6260 31 to to IN cord-015021-pol2qm74 6260 32 Koch Koch NNP cord-015021-pol2qm74 6260 33 - - HYPH cord-015021-pol2qm74 6260 34 Dale Dale NNP cord-015021-pol2qm74 6260 35 analysis analysis NN cord-015021-pol2qm74 6260 36 of of IN cord-015021-pol2qm74 6260 37 causality causality NN cord-015021-pol2qm74 6260 38 by by IN cord-015021-pol2qm74 6260 39 distinguished distinguished JJ cord-015021-pol2qm74 6260 40 authorities authority NNS cord-015021-pol2qm74 6260 41 in in IN cord-015021-pol2qm74 6260 42 the the DT cord-015021-pol2qm74 6260 43 field field NN cord-015021-pol2qm74 6260 44 ( ( -LRB- cord-015021-pol2qm74 6260 45 1 1 CD cord-015021-pol2qm74 6260 46 ) ) -RRB- cord-015021-pol2qm74 6260 47 . . . cord-015021-pol2qm74 6261 1 In in IN cord-015021-pol2qm74 6261 2 summary summary NN cord-015021-pol2qm74 6261 3 , , , cord-015021-pol2qm74 6261 4 our -PRON- PRP$ cord-015021-pol2qm74 6261 5 attempt attempt NN cord-015021-pol2qm74 6261 6 analyze analyze VB cord-015021-pol2qm74 6261 7 available available JJ cord-015021-pol2qm74 6261 8 evidence evidence NN cord-015021-pol2qm74 6261 9 to to TO cord-015021-pol2qm74 6261 10 support support VB cord-015021-pol2qm74 6261 11 a a DT cord-015021-pol2qm74 6261 12 cause cause NN cord-015021-pol2qm74 6261 13 - - HYPH cord-015021-pol2qm74 6261 14 and and CC cord-015021-pol2qm74 6261 15 - - HYPH cord-015021-pol2qm74 6261 16 effect effect NN cord-015021-pol2qm74 6261 17 relationship relationship NN cord-015021-pol2qm74 6261 18 for for IN cord-015021-pol2qm74 6261 19 putative putative JJ cord-015021-pol2qm74 6261 20 mediators mediator NNS cord-015021-pol2qm74 6261 21 of of IN cord-015021-pol2qm74 6261 22 septic septic JJ cord-015021-pol2qm74 6261 23 shock shock NN cord-015021-pol2qm74 6261 24 revealed reveal VBD cord-015021-pol2qm74 6261 25 that that IN cord-015021-pol2qm74 6261 26 only only RB cord-015021-pol2qm74 6261 27 eight eight CD cord-015021-pol2qm74 6261 28 of of IN cord-015021-pol2qm74 6261 29 the the DT cord-015021-pol2qm74 6261 30 24 24 CD cord-015021-pol2qm74 6261 31 mediators mediator NNS cord-015021-pol2qm74 6261 32 analyzed analyze VBN cord-015021-pol2qm74 6261 33 could could MD cord-015021-pol2qm74 6261 34 be be VB cord-015021-pol2qm74 6261 35 strongly strongly RB cord-015021-pol2qm74 6261 36 inferred infer VBN cord-015021-pol2qm74 6261 37 as as IN cord-015021-pol2qm74 6261 38 playing play VBG cord-015021-pol2qm74 6261 39 a a DT cord-015021-pol2qm74 6261 40 causal causal JJ cord-015021-pol2qm74 6261 41 role role NN cord-015021-pol2qm74 6261 42 in in IN cord-015021-pol2qm74 6261 43 septic septic JJ cord-015021-pol2qm74 6261 44 shock shock NN cord-015021-pol2qm74 6261 45 . . . cord-015021-pol2qm74 6262 1 Evidence evidence NN cord-015021-pol2qm74 6262 2 supported support VBD cord-015021-pol2qm74 6262 3 the the DT cord-015021-pol2qm74 6262 4 involvement involvement NN cord-015021-pol2qm74 6262 5 of of IN cord-015021-pol2qm74 6262 6 endotoxln endotoxln NNP cord-015021-pol2qm74 6262 7 , , , cord-015021-pol2qm74 6262 8 endorphins endorphin NNS cord-015021-pol2qm74 6262 9 , , , cord-015021-pol2qm74 6262 10 complement complement NN cord-015021-pol2qm74 6262 11 , , , cord-015021-pol2qm74 6262 12 interleukins interleukin NNS cord-015021-pol2qm74 6262 13 , , , cord-015021-pol2qm74 6262 14 tumor tumor NN cord-015021-pol2qm74 6262 15 necrosis necrosis NN cord-015021-pol2qm74 6262 16 factor factor NN cord-015021-pol2qm74 6262 17 , , , cord-015021-pol2qm74 6262 18 eieosanoids eieosanoid NNS cord-015021-pol2qm74 6262 19 , , , cord-015021-pol2qm74 6262 20 platelet platelet NN cord-015021-pol2qm74 6262 21 activating activate VBG cord-015021-pol2qm74 6262 22 factor factor NN cord-015021-pol2qm74 6262 23 and and CC cord-015021-pol2qm74 6262 24 calcium calcium NN cord-015021-pol2qm74 6262 25 . . . cord-015021-pol2qm74 6263 1 Other other JJ cord-015021-pol2qm74 6263 2 mediators mediator NNS cord-015021-pol2qm74 6263 3 either either CC cord-015021-pol2qm74 6263 4 lacked lack VBD cord-015021-pol2qm74 6263 5 adequate adequate JJ cord-015021-pol2qm74 6263 6 supportive supportive JJ cord-015021-pol2qm74 6263 7 evidence evidence NN cord-015021-pol2qm74 6263 8 or or CC cord-015021-pol2qm74 6263 9 were be VBD cord-015021-pol2qm74 6263 10 not not RB cord-015021-pol2qm74 6263 11 conclusively conclusively RB cord-015021-pol2qm74 6263 12 involved involve VBN cord-015021-pol2qm74 6263 13 . . . cord-015021-pol2qm74 6264 1 Posttraumatic posttraumatic JJ cord-015021-pol2qm74 6264 2 outcome outcome NN cord-015021-pol2qm74 6264 3 may may MD cord-015021-pol2qm74 6264 4 be be VB cord-015021-pol2qm74 6264 5 reduced reduce VBN cord-015021-pol2qm74 6264 6 by by IN cord-015021-pol2qm74 6264 7 an an DT cord-015021-pol2qm74 6264 8 amplified amplify VBN cord-015021-pol2qm74 6264 9 stress stress NN cord-015021-pol2qm74 6264 10 response response NN cord-015021-pol2qm74 6264 11 mediated mediate VBN cord-015021-pol2qm74 6264 12 by by IN cord-015021-pol2qm74 6264 13 neural neural JJ cord-015021-pol2qm74 6264 14 and and CC cord-015021-pol2qm74 6264 15 humoral humoral JJ cord-015021-pol2qm74 6264 16 stimuli stimulus NNS cord-015021-pol2qm74 6264 17 . . . cord-015021-pol2qm74 6265 1 The the DT cord-015021-pol2qm74 6265 2 classical classical JJ cord-015021-pol2qm74 6265 3 hormonal hormonal JJ cord-015021-pol2qm74 6265 4 catabolic catabolic JJ cord-015021-pol2qm74 6265 5 response response NN cord-015021-pol2qm74 6265 6 is be VBZ cord-015021-pol2qm74 6265 7 predominantly predominantly RB cord-015021-pol2qm74 6265 8 mediated mediate VBN cord-015021-pol2qm74 6265 9 directly directly RB cord-015021-pol2qm74 6265 10 or or CC cord-015021-pol2qm74 6265 11 indirectly indirectly RB cord-015021-pol2qm74 6265 12 by by IN cord-015021-pol2qm74 6265 13 neural neural JJ cord-015021-pol2qm74 6265 14 stimuli stimulus NNS cord-015021-pol2qm74 6265 15 , , , cord-015021-pol2qm74 6265 16 while while IN cord-015021-pol2qm74 6265 17 most most JJS cord-015021-pol2qm74 6265 18 changes change NNS cord-015021-pol2qm74 6265 19 in in IN cord-015021-pol2qm74 6265 20 inflammatory inflammatory JJ cord-015021-pol2qm74 6265 21 responses response NNS cord-015021-pol2qm74 6265 22 such such JJ cord-015021-pol2qm74 6265 23 as as IN cord-015021-pol2qm74 6265 24 leukocytosis leukocytosis NNP cord-015021-pol2qm74 6265 25 , , , cord-015021-pol2qm74 6265 26 acute acute JJ cord-015021-pol2qm74 6265 27 phase phase NN cord-015021-pol2qm74 6265 28 proteins protein NNS cord-015021-pol2qm74 6265 29 and and CC cord-015021-pol2qm74 6265 30 changes change NNS cord-015021-pol2qm74 6265 31 immunofunction immunofunction NN cord-015021-pol2qm74 6265 32 are be VBP cord-015021-pol2qm74 6265 33 mediated mediate VBN cord-015021-pol2qm74 6265 34 by by IN cord-015021-pol2qm74 6265 35 humoral humoral JJ cord-015021-pol2qm74 6265 36 mediators mediator NNS cord-015021-pol2qm74 6265 37 . . . cord-015021-pol2qm74 6266 1 Clinical clinical JJ cord-015021-pol2qm74 6266 2 experience experience NN cord-015021-pol2qm74 6266 3 from from IN cord-015021-pol2qm74 6266 4 controlled control VBN cord-015021-pol2qm74 6266 5 studies study NNS cord-015021-pol2qm74 6266 6 suggest suggest VBP cord-015021-pol2qm74 6266 7 afferent afferent JJ cord-015021-pol2qm74 6266 8 neural neural JJ cord-015021-pol2qm74 6266 9 blockade blockade NN cord-015021-pol2qm74 6266 10 and and CC cord-015021-pol2qm74 6266 11 modification modification NN cord-015021-pol2qm74 6266 12 of of IN cord-015021-pol2qm74 6266 13 stress stress NN cord-015021-pol2qm74 6266 14 response response NN cord-015021-pol2qm74 6266 15 to to TO cord-015021-pol2qm74 6266 16 improve improve VB cord-015021-pol2qm74 6266 17 organ organ NN cord-015021-pol2qm74 6266 18 function function NN cord-015021-pol2qm74 6266 19 and and CC cord-015021-pol2qm74 6266 20 postoperative postoperative JJ cord-015021-pol2qm74 6266 21 outcome outcome NN cord-015021-pol2qm74 6266 22 , , , cord-015021-pol2qm74 6266 23 and and CC cord-015021-pol2qm74 6266 24 limited limited JJ cord-015021-pol2qm74 6266 25 experimental experimental JJ cord-015021-pol2qm74 6266 26 studies study NNS cord-015021-pol2qm74 6266 27 also also RB cord-015021-pol2qm74 6266 28 suggest suggest VBP cord-015021-pol2qm74 6266 29 neural neural JJ cord-015021-pol2qm74 6266 30 blockade blockade NN cord-015021-pol2qm74 6266 31 to to TO cord-015021-pol2qm74 6266 32 be be VB cord-015021-pol2qm74 6266 33 of of IN cord-015021-pol2qm74 6266 34 beneficial beneficial JJ cord-015021-pol2qm74 6266 35 value value NN cord-015021-pol2qm74 6266 36 in in IN cord-015021-pol2qm74 6266 37 shock shock NN cord-015021-pol2qm74 6266 38 states state NNS cord-015021-pol2qm74 6266 39 . . . cord-015021-pol2qm74 6267 1 Of of IN cord-015021-pol2qm74 6267 2 special special JJ cord-015021-pol2qm74 6267 3 value value NN cord-015021-pol2qm74 6267 4 may may MD cord-015021-pol2qm74 6267 5 be be VB cord-015021-pol2qm74 6267 6 the the DT cord-015021-pol2qm74 6267 7 improved improve VBN cord-015021-pol2qm74 6267 8 gastro gastro JJ cord-015021-pol2qm74 6267 9 - - JJ cord-015021-pol2qm74 6267 10 intestinal intestinal JJ cord-015021-pol2qm74 6267 11 motility motility NN cord-015021-pol2qm74 6267 12 after after IN cord-015021-pol2qm74 6267 13 neural neural JJ cord-015021-pol2qm74 6267 14 ( ( -LRB- cord-015021-pol2qm74 6267 15 visceral visceral JJ cord-015021-pol2qm74 6267 16 ) ) -RRB- cord-015021-pol2qm74 6267 17 blockade blockade NN cord-015021-pol2qm74 6267 18 . . . cord-015021-pol2qm74 6268 1 No no DT cord-015021-pol2qm74 6268 2 outcome outcome NN cord-015021-pol2qm74 6268 3 studies study NNS cord-015021-pol2qm74 6268 4 are be VBP cord-015021-pol2qm74 6268 5 available available JJ cord-015021-pol2qm74 6268 6 from from IN cord-015021-pol2qm74 6268 7 patients patient NNS cord-015021-pol2qm74 6268 8 with with IN cord-015021-pol2qm74 6268 9 major major JJ cord-015021-pol2qm74 6268 10 truma truma NNP cord-015021-pol2qm74 6268 11 , , , cord-015021-pol2qm74 6268 12 multiple multiple JJ cord-015021-pol2qm74 6268 13 organ organ NN cord-015021-pol2qm74 6268 14 failure failure NN cord-015021-pol2qm74 6268 15 or or CC cord-015021-pol2qm74 6268 16 sepsis sepsis NN cord-015021-pol2qm74 6268 17 , , , cord-015021-pol2qm74 6268 18 conditions condition NNS cord-015021-pol2qm74 6268 19 where where WRB cord-015021-pol2qm74 6268 20 humorai humorai NNP cord-015021-pol2qm74 6268 21 mediators mediator NNS cord-015021-pol2qm74 6268 22 may may MD cord-015021-pol2qm74 6268 23 be be VB cord-015021-pol2qm74 6268 24 more more RBR cord-015021-pol2qm74 6268 25 important important JJ cord-015021-pol2qm74 6268 26 to to TO cord-015021-pol2qm74 6268 27 modify modify VB cord-015021-pol2qm74 6268 28 than than IN cord-015021-pol2qm74 6268 29 neurally neurally RB cord-015021-pol2qm74 6268 30 mediated mediate VBN cord-015021-pol2qm74 6268 31 responses response NNS cord-015021-pol2qm74 6268 32 . . . cord-015021-pol2qm74 6269 1 Future future JJ cord-015021-pol2qm74 6269 2 studies study NNS cord-015021-pol2qm74 6269 3 should should MD cord-015021-pol2qm74 6269 4 investigate investigate VB cord-015021-pol2qm74 6269 5 the the DT cord-015021-pol2qm74 6269 6 clinical clinical JJ cord-015021-pol2qm74 6269 7 outcome outcome NN cord-015021-pol2qm74 6269 8 effect effect NN cord-015021-pol2qm74 6269 9 of of IN cord-015021-pol2qm74 6269 10 combined combine VBN cord-015021-pol2qm74 6269 11 neural neural JJ cord-015021-pol2qm74 6269 12 and and CC cord-015021-pol2qm74 6269 13 humoral humoral JJ cord-015021-pol2qm74 6269 14 mediated mediate VBN cord-015021-pol2qm74 6269 15 blockade blockade NN cord-015021-pol2qm74 6269 16 , , , cord-015021-pol2qm74 6269 17 as as RB cord-015021-pol2qm74 6269 18 well well RB cord-015021-pol2qm74 6269 19 as as IN cord-015021-pol2qm74 6269 20 the the DT cord-015021-pol2qm74 6269 21 potential potential JJ cord-015021-pol2qm74 6269 22 role role NN cord-015021-pol2qm74 6269 23 of of IN cord-015021-pol2qm74 6269 24 an an DT cord-015021-pol2qm74 6269 25 initial initial JJ cord-015021-pol2qm74 6269 26 neural neural JJ cord-015021-pol2qm74 6269 27 blockade blockade NN cord-015021-pol2qm74 6269 28 in in IN cord-015021-pol2qm74 6269 29 elective elective JJ cord-015021-pol2qm74 6269 30 trauma trauma NN cord-015021-pol2qm74 6269 31 ( ( -LRB- cord-015021-pol2qm74 6269 32 first first RB cord-015021-pol2qm74 6269 33 hit hit VBN cord-015021-pol2qm74 6269 34 ) ) -RRB- cord-015021-pol2qm74 6269 35 to to TO cord-015021-pol2qm74 6269 36 improve improve VB cord-015021-pol2qm74 6269 37 the the DT cord-015021-pol2qm74 6269 38 metabolic metabolic JJ cord-015021-pol2qm74 6269 39 scene scene NN cord-015021-pol2qm74 6269 40 and and CC cord-015021-pol2qm74 6269 41 outcome outcome NN cord-015021-pol2qm74 6269 42 if if IN cord-015021-pol2qm74 6269 43 a a DT cord-015021-pol2qm74 6269 44 postoperative postoperative JJ cord-015021-pol2qm74 6269 45 complication complication NN cord-015021-pol2qm74 6269 46 ( ( -LRB- cord-015021-pol2qm74 6269 47 second second RB cord-015021-pol2qm74 6269 48 hit hit NN cord-015021-pol2qm74 6269 49 ) ) -RRB- cord-015021-pol2qm74 6269 50 should should MD cord-015021-pol2qm74 6269 51 occur occur VB cord-015021-pol2qm74 6269 52 . . . cord-015021-pol2qm74 6270 1 Neutrophil Neutrophil NNP cord-015021-pol2qm74 6270 2 elastase elastase NN cord-015021-pol2qm74 6270 3 is be VBZ cord-015021-pol2qm74 6270 4 the the DT cord-015021-pol2qm74 6270 5 predominant predominant JJ cord-015021-pol2qm74 6270 6 protease protease NN cord-015021-pol2qm74 6270 7 of of IN cord-015021-pol2qm74 6270 8 the the DT cord-015021-pol2qm74 6270 9 human human JJ cord-015021-pol2qm74 6270 10 neutrophil neutrophil NN cord-015021-pol2qm74 6270 11 . . . cord-015021-pol2qm74 6271 1 This this DT cord-015021-pol2qm74 6271 2 enzyme enzyme NN cord-015021-pol2qm74 6271 3 , , , cord-015021-pol2qm74 6271 4 and and CC cord-015021-pol2qm74 6271 5 a a DT cord-015021-pol2qm74 6271 6 variety variety NN cord-015021-pol2qm74 6271 7 of of IN cord-015021-pol2qm74 6271 8 other other JJ cord-015021-pol2qm74 6271 9 enzymes enzyme NNS cord-015021-pol2qm74 6271 10 , , , cord-015021-pol2qm74 6271 11 including include VBG cord-015021-pol2qm74 6271 12 neutrophil neutrophil NN cord-015021-pol2qm74 6271 13 collagenase collagenase NNP cord-015021-pol2qm74 6271 14 , , , cord-015021-pol2qm74 6271 15 are be VBP cord-015021-pol2qm74 6271 16 released release VBN cord-015021-pol2qm74 6271 17 by by IN cord-015021-pol2qm74 6271 18 activated activate VBN cord-015021-pol2qm74 6271 19 neutrophils neutrophil NNS cord-015021-pol2qm74 6271 20 in in IN cord-015021-pol2qm74 6271 21 the the DT cord-015021-pol2qm74 6271 22 setting setting NN cord-015021-pol2qm74 6271 23 of of IN cord-015021-pol2qm74 6271 24 high high JJ cord-015021-pol2qm74 6271 25 concentrations concentration NNS cord-015021-pol2qm74 6271 26 of of IN cord-015021-pol2qm74 6271 27 reactive reactive JJ cord-015021-pol2qm74 6271 28 oxygen oxygen NN cord-015021-pol2qm74 6271 29 metabolites metabolite NNS cord-015021-pol2qm74 6271 30 . . . cord-015021-pol2qm74 6272 1 In in IN cord-015021-pol2qm74 6272 2 addition addition NN cord-015021-pol2qm74 6272 3 , , , cord-015021-pol2qm74 6272 4 in in IN cord-015021-pol2qm74 6272 5 this this DT cord-015021-pol2qm74 6272 6 extracellular extracellular JJ cord-015021-pol2qm74 6272 7 environment environment NN cord-015021-pol2qm74 6272 8 , , , cord-015021-pol2qm74 6272 9 the the DT cord-015021-pol2qm74 6272 10 normal normal JJ cord-015021-pol2qm74 6272 11 antiprotease antiprotease NN cord-015021-pol2qm74 6272 12 defense defense NN cord-015021-pol2qm74 6272 13 mechanisms mechanism NNS cord-015021-pol2qm74 6272 14 of of IN cord-015021-pol2qm74 6272 15 the the DT cord-015021-pol2qm74 6272 16 organism organism NN cord-015021-pol2qm74 6272 17 may may MD cord-015021-pol2qm74 6272 18 have have VB cord-015021-pol2qm74 6272 19 been be VBN cord-015021-pol2qm74 6272 20 severely severely RB cord-015021-pol2qm74 6272 21 inactivated inactivate VBN cord-015021-pol2qm74 6272 22 oxidatively oxidatively RB cord-015021-pol2qm74 6272 23 especially especially RB cord-015021-pol2qm74 6272 24 along along IN cord-015021-pol2qm74 6272 25 capillary capillary JJ cord-015021-pol2qm74 6272 26 endothelial endothelial JJ cord-015021-pol2qm74 6272 27 cells cell NNS cord-015021-pol2qm74 6272 28 . . . cord-015021-pol2qm74 6273 1 Accordingly accordingly RB cord-015021-pol2qm74 6273 2 , , , cord-015021-pol2qm74 6273 3 release release NN cord-015021-pol2qm74 6273 4 of of IN cord-015021-pol2qm74 6273 5 neutrophil neutrophil NN cord-015021-pol2qm74 6273 6 elastase elastase NN cord-015021-pol2qm74 6273 7 which which WDT cord-015021-pol2qm74 6273 8 mediates mediate VBZ cord-015021-pol2qm74 6273 9 inflammation inflammation NN cord-015021-pol2qm74 6273 10 and and CC cord-015021-pol2qm74 6273 11 degrades degrade VBZ cord-015021-pol2qm74 6273 12 most most RBS cord-015021-pol2qm74 6273 13 extracellular extracellular JJ cord-015021-pol2qm74 6273 14 matrix matrix NN cord-015021-pol2qm74 6273 15 proteins protein NNS cord-015021-pol2qm74 6273 16 , , , cord-015021-pol2qm74 6273 17 including include VBG cord-015021-pol2qm74 6273 18 elastin elastin NN cord-015021-pol2qm74 6273 19 , , , cord-015021-pol2qm74 6273 20 fibronectin fibronectin NN cord-015021-pol2qm74 6273 21 and and CC cord-015021-pol2qm74 6273 22 many many JJ cord-015021-pol2qm74 6273 23 forms form NNS cord-015021-pol2qm74 6273 24 of of IN cord-015021-pol2qm74 6273 25 collagen collagen NN cord-015021-pol2qm74 6273 26 , , , cord-015021-pol2qm74 6273 27 may may MD cord-015021-pol2qm74 6273 28 contribute contribute VB cord-015021-pol2qm74 6273 29 to to IN cord-015021-pol2qm74 6273 30 tissue tissue NN cord-015021-pol2qm74 6273 31 injury injury NN cord-015021-pol2qm74 6273 32 and and CC cord-015021-pol2qm74 6273 33 organ organ NN cord-015021-pol2qm74 6273 34 failure failure NN cord-015021-pol2qm74 6273 35 in in IN cord-015021-pol2qm74 6273 36 a a DT cord-015021-pol2qm74 6273 37 variety variety NN cord-015021-pol2qm74 6273 38 of of IN cord-015021-pol2qm74 6273 39 diseases disease NNS cord-015021-pol2qm74 6273 40 ranging range VBG cord-015021-pol2qm74 6273 41 in in IN cord-015021-pol2qm74 6273 42 severity severity NN cord-015021-pol2qm74 6273 43 and and CC cord-015021-pol2qm74 6273 44 acuity acuity NN cord-015021-pol2qm74 6273 45 from from IN cord-015021-pol2qm74 6273 46 pulmonary pulmonary JJ cord-015021-pol2qm74 6273 47 emphysema emphysema NN cord-015021-pol2qm74 6273 48 to to IN cord-015021-pol2qm74 6273 49 the the DT cord-015021-pol2qm74 6273 50 Adult Adult NNP cord-015021-pol2qm74 6273 51 Respiratory Respiratory NNP cord-015021-pol2qm74 6273 52 Distress Distress NNP cord-015021-pol2qm74 6273 53 syndrome syndrome NN cord-015021-pol2qm74 6273 54 ( ( -LRB- cord-015021-pol2qm74 6273 55 ARDS ARDS NNP cord-015021-pol2qm74 6273 56 ) ) -RRB- cord-015021-pol2qm74 6273 57 . . . cord-015021-pol2qm74 6274 1 As as IN cord-015021-pol2qm74 6274 2 a a DT cord-015021-pol2qm74 6274 3 result result NN cord-015021-pol2qm74 6274 4 , , , cord-015021-pol2qm74 6274 5 significant significant JJ cord-015021-pol2qm74 6274 6 efforts effort NNS cord-015021-pol2qm74 6274 7 by by IN cord-015021-pol2qm74 6274 8 the the DT cord-015021-pol2qm74 6274 9 pharmaceutical pharmaceutical NN cord-015021-pol2qm74 6274 10 industry industry NN cord-015021-pol2qm74 6274 11 have have VBP cord-015021-pol2qm74 6274 12 been be VBN cord-015021-pol2qm74 6274 13 directed direct VBN cord-015021-pol2qm74 6274 14 not not RB cord-015021-pol2qm74 6274 15 only only RB cord-015021-pol2qm74 6274 16 toward toward IN cord-015021-pol2qm74 6274 17 the the DT cord-015021-pol2qm74 6274 18 development development NN cord-015021-pol2qm74 6274 19 of of IN cord-015021-pol2qm74 6274 20 human human JJ cord-015021-pol2qm74 6274 21 neutrophil neutrophil NN cord-015021-pol2qm74 6274 22 elastase elastase NN cord-015021-pol2qm74 6274 23 inhibitors inhibitor NNS cord-015021-pol2qm74 6274 24 , , , cord-015021-pol2qm74 6274 25 but but CC cord-015021-pol2qm74 6274 26 also also RB cord-015021-pol2qm74 6274 27 toward toward IN cord-015021-pol2qm74 6274 28 their -PRON- PRP$ cord-015021-pol2qm74 6274 29 characterization characterization NN cord-015021-pol2qm74 6274 30 in in IN cord-015021-pol2qm74 6274 31 a a DT cord-015021-pol2qm74 6274 32 variety variety NN cord-015021-pol2qm74 6274 33 of of IN cord-015021-pol2qm74 6274 34 animal animal NN cord-015021-pol2qm74 6274 35 models model NNS cord-015021-pol2qm74 6274 36 of of IN cord-015021-pol2qm74 6274 37 neutrophil neutrophil NN cord-015021-pol2qm74 6274 38 mediated mediate VBN cord-015021-pol2qm74 6274 39 diseases disease NNS cord-015021-pol2qm74 6274 40 , , , cord-015021-pol2qm74 6274 41 and and CC cord-015021-pol2qm74 6274 42 their -PRON- PRP$ cord-015021-pol2qm74 6274 43 evaluation evaluation NN cord-015021-pol2qm74 6274 44 as as IN cord-015021-pol2qm74 6274 45 potential potential JJ cord-015021-pol2qm74 6274 46 therapeutics therapeutic NNS cord-015021-pol2qm74 6274 47 for for IN cord-015021-pol2qm74 6274 48 the the DT cord-015021-pol2qm74 6274 49 treatment treatment NN cord-015021-pol2qm74 6274 50 of of IN cord-015021-pol2qm74 6274 51 a a DT cord-015021-pol2qm74 6274 52 variety variety NN cord-015021-pol2qm74 6274 53 of of IN cord-015021-pol2qm74 6274 54 human human JJ cord-015021-pol2qm74 6274 55 clinical clinical JJ cord-015021-pol2qm74 6274 56 conditions condition NNS cord-015021-pol2qm74 6274 57 . . . cord-015021-pol2qm74 6275 1 Data datum NNS cord-015021-pol2qm74 6275 2 from from IN cord-015021-pol2qm74 6275 3 animal animal NN cord-015021-pol2qm74 6275 4 models model NNS cord-015021-pol2qm74 6275 5 of of IN cord-015021-pol2qm74 6275 6 organ organ NN cord-015021-pol2qm74 6275 7 injury injury NN cord-015021-pol2qm74 6275 8 and and CC cord-015021-pol2qm74 6275 9 failure failure NN cord-015021-pol2qm74 6275 10 along along IN cord-015021-pol2qm74 6275 11 with with IN cord-015021-pol2qm74 6275 12 data datum NNS cord-015021-pol2qm74 6275 13 collected collect VBN cord-015021-pol2qm74 6275 14 from from IN cord-015021-pol2qm74 6275 15 a a DT cord-015021-pol2qm74 6275 16 series series NN cord-015021-pol2qm74 6275 17 of of IN cord-015021-pol2qm74 6275 18 patients patient NNS cord-015021-pol2qm74 6275 19 at at IN cord-015021-pol2qm74 6275 20 risk risk NN cord-015021-pol2qm74 6275 21 for for IN cord-015021-pol2qm74 6275 22 ARDS ARDS NNP cord-015021-pol2qm74 6275 23 and and CC cord-015021-pol2qm74 6275 24 with with IN cord-015021-pol2qm74 6275 25 ARDS ARDS NNP cord-015021-pol2qm74 6275 26 will will MD cord-015021-pol2qm74 6275 27 be be VB cord-015021-pol2qm74 6275 28 presented present VBN cord-015021-pol2qm74 6275 29 and and CC cord-015021-pol2qm74 6275 30 discussed discuss VBN cord-015021-pol2qm74 6275 31 as as IN cord-015021-pol2qm74 6275 32 a a DT cord-015021-pol2qm74 6275 33 rationale rationale NN cord-015021-pol2qm74 6275 34 for for IN cord-015021-pol2qm74 6275 35 inhibition inhibition NN cord-015021-pol2qm74 6275 36 of of IN cord-015021-pol2qm74 6275 37 neutrophil neutrophil NN cord-015021-pol2qm74 6275 38 elastase elastase NN cord-015021-pol2qm74 6275 39 . . . cord-015021-pol2qm74 6276 1 Parameters parameter NNS cord-015021-pol2qm74 6276 2 that that WDT cord-015021-pol2qm74 6276 3 need need VBP cord-015021-pol2qm74 6276 4 to to TO cord-015021-pol2qm74 6276 5 be be VB cord-015021-pol2qm74 6276 6 monitored monitor VBN cord-015021-pol2qm74 6276 7 to to TO cord-015021-pol2qm74 6276 8 obtain obtain VB cord-015021-pol2qm74 6276 9 success success NN cord-015021-pol2qm74 6276 10 in in IN cord-015021-pol2qm74 6276 11 future future JJ cord-015021-pol2qm74 6276 12 clinical clinical JJ cord-015021-pol2qm74 6276 13 studies study NNS cord-015021-pol2qm74 6276 14 will will MD cord-015021-pol2qm74 6276 15 also also RB cord-015021-pol2qm74 6276 16 be be VB cord-015021-pol2qm74 6276 17 presented present VBN cord-015021-pol2qm74 6276 18 in in IN cord-015021-pol2qm74 6276 19 this this DT cord-015021-pol2qm74 6276 20 context context NN cord-015021-pol2qm74 6276 21 . . . cord-015021-pol2qm74 6277 1 have have VBP cord-015021-pol2qm74 6277 2 turned turn VBN cord-015021-pol2qm74 6277 3 out out RP cord-015021-pol2qm74 6277 4 to to TO cord-015021-pol2qm74 6277 5 initiate initiate VB cord-015021-pol2qm74 6277 6 and and CC cord-015021-pol2qm74 6277 7 maintain maintain VB cord-015021-pol2qm74 6277 8 organ organ NN cord-015021-pol2qm74 6277 9 dysfunctions dysfunction NNS cord-015021-pol2qm74 6277 10 in in IN cord-015021-pol2qm74 6277 11 severe severe JJ cord-015021-pol2qm74 6277 12 posttraumatic posttraumatic JJ cord-015021-pol2qm74 6277 13 and and CC cord-015021-pol2qm74 6277 14 postoperative postoperative JJ cord-015021-pol2qm74 6277 15 courses course NNS cord-015021-pol2qm74 6277 16 . . . cord-015021-pol2qm74 6278 1 Such such JJ cord-015021-pol2qm74 6278 2 proteolysis proteolysis NN cord-015021-pol2qm74 6278 3 - - HYPH cord-015021-pol2qm74 6278 4 induced induce VBN cord-015021-pol2qm74 6278 5 disorders disorder NNS cord-015021-pol2qm74 6278 6 are be VBP cord-015021-pol2qm74 6278 7 especially especially RB cord-015021-pol2qm74 6278 8 rendered render VBN cord-015021-pol2qm74 6278 9 possible possible JJ cord-015021-pol2qm74 6278 10 by by IN cord-015021-pol2qm74 6278 11 the the DT cord-015021-pol2qm74 6278 12 concurrently concurrently RB cord-015021-pol2qm74 6278 13 arising arise VBG cord-015021-pol2qm74 6278 14 consumption consumption NN cord-015021-pol2qm74 6278 15 of of IN cord-015021-pol2qm74 6278 16 inhibitory inhibitory JJ cord-015021-pol2qm74 6278 17 regulators regulator NNS cord-015021-pol2qm74 6278 18 ( ( -LRB- cord-015021-pol2qm74 6278 19 e.g. e.g. RB cord-015021-pol2qm74 6278 20 a a DT cord-015021-pol2qm74 6278 21 Vproteinase Vproteinase NNP cord-015021-pol2qm74 6278 22 inhibitor inhibitor NN cord-015021-pol2qm74 6278 23 = = VBZ cord-015021-pol2qm74 6278 24 a a DT cord-015021-pol2qm74 6278 25 1PI 1pi CD cord-015021-pol2qm74 6278 26 , , , cord-015021-pol2qm74 6278 27 antithrombin antithrombin NN cord-015021-pol2qm74 6278 28 III III NNP cord-015021-pol2qm74 6278 29 = = SYM cord-015021-pol2qm74 6278 30 AT at IN cord-015021-pol2qm74 6278 31 III III NNP cord-015021-pol2qm74 6278 32 ) ) -RRB- cord-015021-pol2qm74 6278 33 via via IN cord-015021-pol2qm74 6278 34 cofnplex cofnplex NN cord-015021-pol2qm74 6278 35 formation formation NN cord-015021-pol2qm74 6278 36 and and CC cord-015021-pol2qm74 6278 37 / / SYM cord-015021-pol2qm74 6278 38 of of IN cord-015021-pol2qm74 6278 39 proteolytic proteolytic JJ cord-015021-pol2qm74 6278 40 / / SYM cord-015021-pol2qm74 6278 41 oxidative oxidative JJ cord-015021-pol2qm74 6278 42 inactivation inactivation NN cord-015021-pol2qm74 6278 43 . . . cord-015021-pol2qm74 6279 1 Besides besides IN cord-015021-pol2qm74 6279 2 the the DT cord-015021-pol2qm74 6279 3 well well RB cord-015021-pol2qm74 6279 4 - - HYPH cord-015021-pol2qm74 6279 5 known know VBN cord-015021-pol2qm74 6279 6 destructive destructive JJ cord-015021-pol2qm74 6279 7 potency potency NN cord-015021-pol2qm74 6279 8 against against IN cord-015021-pol2qm74 6279 9 protein protein NN cord-015021-pol2qm74 6279 10 substrates substrate NNS cord-015021-pol2qm74 6279 11 , , , cord-015021-pol2qm74 6279 12 proteinases proteinase VBZ cord-015021-pol2qm74 6279 13 such such JJ cord-015021-pol2qm74 6279 14 as as IN cord-015021-pol2qm74 6279 15 elastase elastase NN cord-015021-pol2qm74 6279 16 or or CC cord-015021-pol2qm74 6279 17 thrombin thrombin NN cord-015021-pol2qm74 6279 18 ( ( -LRB- cord-015021-pol2qm74 6279 19 active active JJ cord-015021-pol2qm74 6279 20 or or CC cord-015021-pol2qm74 6279 21 in in IN cord-015021-pol2qm74 6279 22 complex complex NN cord-015021-pol2qm74 6279 23 with with IN cord-015021-pol2qm74 6279 24 the the DT cord-015021-pol2qm74 6279 25 serpin serpin NN cord-015021-pol2qm74 6279 26 inhibitors inhibitor NNS cord-015021-pol2qm74 6279 27 ~ ~ NFP cord-015021-pol2qm74 6279 28 1PI 1pi CD cord-015021-pol2qm74 6279 29 or or CC cord-015021-pol2qm74 6279 30 AT AT NNP cord-015021-pol2qm74 6279 31 III III NNP cord-015021-pol2qm74 6279 32 ) ) -RRB- cord-015021-pol2qm74 6279 33 are be VBP cord-015021-pol2qm74 6279 34 also also RB cord-015021-pol2qm74 6279 35 supposed suppose VBN cord-015021-pol2qm74 6279 36 to to TO cord-015021-pol2qm74 6279 37 increase increase VB cord-015021-pol2qm74 6279 38 the the DT cord-015021-pol2qm74 6279 39 inflammatory inflammatory JJ cord-015021-pol2qm74 6279 40 reaction reaction NN cord-015021-pol2qm74 6279 41 by by IN cord-015021-pol2qm74 6279 42 inducing induce VBG cord-015021-pol2qm74 6279 43 cytokine cytokine NN cord-015021-pol2qm74 6279 44 release release NN cord-015021-pol2qm74 6279 45 or or CC cord-015021-pol2qm74 6279 46 shedding shedding NN cord-015021-pol2qm74 6279 47 of of IN cord-015021-pol2qm74 6279 48 soIuble soIuble NNP cord-015021-pol2qm74 6279 49 adhesion adhesion NN cord-015021-pol2qm74 6279 50 molecules molecule NNS cord-015021-pol2qm74 6279 51 from from IN cord-015021-pol2qm74 6279 52 various various JJ cord-015021-pol2qm74 6279 53 inflammatory inflammatory JJ cord-015021-pol2qm74 6279 54 cells cell NNS cord-015021-pol2qm74 6279 55 ( ( -LRB- cord-015021-pol2qm74 6279 56 PMNs pmn NNS cord-015021-pol2qm74 6279 57 , , , cord-015021-pol2qm74 6279 58 monocytes monocyte NNS cord-015021-pol2qm74 6279 59 / / SYM cord-015021-pol2qm74 6279 60 macrophages macrophage NNS cord-015021-pol2qm74 6279 61 , , , cord-015021-pol2qm74 6279 62 endothelial endothelial JJ cord-015021-pol2qm74 6279 63 cells cell NNS cord-015021-pol2qm74 6279 64 ) ) -RRB- cord-015021-pol2qm74 6279 65 . . . cord-015021-pol2qm74 6280 1 Those those DT cord-015021-pol2qm74 6280 2 cell cell NN cord-015021-pol2qm74 6280 3 - - HYPH cord-015021-pol2qm74 6280 4 derived derive VBN cord-015021-pol2qm74 6280 5 mediators mediator NNS cord-015021-pol2qm74 6280 6 may may MD cord-015021-pol2qm74 6280 7 provoke provoke VB cord-015021-pol2qm74 6280 8 further further JJ cord-015021-pol2qm74 6280 9 cell cell NN cord-015021-pol2qm74 6280 10 activation activation NN cord-015021-pol2qm74 6280 11 through through IN cord-015021-pol2qm74 6280 12 an an DT cord-015021-pol2qm74 6280 13 autocrine autocrine JJ cord-015021-pol2qm74 6280 14 / / SYM cord-015021-pol2qm74 6280 15 paracrine paracrine NN cord-015021-pol2qm74 6280 16 loop loop NN cord-015021-pol2qm74 6280 17 thus thus RB cord-015021-pol2qm74 6280 18 increasing increase VBG cord-015021-pol2qm74 6280 19 significantly significantly RB cord-015021-pol2qm74 6280 20 the the DT cord-015021-pol2qm74 6280 21 proteinase proteinase NN cord-015021-pol2qm74 6280 22 burden burden NN cord-015021-pol2qm74 6280 23 at at IN cord-015021-pol2qm74 6280 24 the the DT cord-015021-pol2qm74 6280 25 inflammatory inflammatory JJ cord-015021-pol2qm74 6280 26 focus focus NN cord-015021-pol2qm74 6280 27 . . . cord-015021-pol2qm74 6281 1 Therefore therefore RB cord-015021-pol2qm74 6281 2 , , , cord-015021-pol2qm74 6281 3 this this DT cord-015021-pol2qm74 6281 4 noxious noxious JJ cord-015021-pol2qm74 6281 5 circle circle NN cord-015021-pol2qm74 6281 6 might may MD cord-015021-pol2qm74 6281 7 be be VB cord-015021-pol2qm74 6281 8 interrupted interrupt VBN cord-015021-pol2qm74 6281 9 by by IN cord-015021-pol2qm74 6281 10 a a DT cord-015021-pol2qm74 6281 11 convenient convenient JJ cord-015021-pol2qm74 6281 12 proteinase proteinase NN cord-015021-pol2qm74 6281 13 inhibitor inhibitor NN cord-015021-pol2qm74 6281 14 therapy therapy NN cord-015021-pol2qm74 6281 15 to to TO cord-015021-pol2qm74 6281 16 ameliorate ameliorate VB cord-015021-pol2qm74 6281 17 the the DT cord-015021-pol2qm74 6281 18 inflammatory inflammatory JJ cord-015021-pol2qm74 6281 19 process process NN cord-015021-pol2qm74 6281 20 . . . cord-015021-pol2qm74 6282 1 To to TO cord-015021-pol2qm74 6282 2 verify verify VB cord-015021-pol2qm74 6282 3 this this DT cord-015021-pol2qm74 6282 4 hypothesis hypothesis NN cord-015021-pol2qm74 6282 5 , , , cord-015021-pol2qm74 6282 6 high high JJ cord-015021-pol2qm74 6282 7 dosis dosis NN cord-015021-pol2qm74 6282 8 of of IN cord-015021-pol2qm74 6282 9 AT AT NNP cord-015021-pol2qm74 6282 10 III III NNP cord-015021-pol2qm74 6283 1 ( ( -LRB- cord-015021-pol2qm74 6283 2 mean mean VB cord-015021-pol2qm74 6283 3 plasma plasma NN cord-015021-pol2qm74 6283 4 levels level NNS cord-015021-pol2qm74 6283 5 up up IN cord-015021-pol2qm74 6283 6 to to IN cord-015021-pol2qm74 6283 7 140 140 CD cord-015021-pol2qm74 6283 8 % % NN cord-015021-pol2qm74 6283 9 ) ) -RRB- cord-015021-pol2qm74 6283 10 were be VBD cord-015021-pol2qm74 6283 11 applied apply VBN cord-015021-pol2qm74 6283 12 in in IN cord-015021-pol2qm74 6283 13 first first RB cord-015021-pol2qm74 6283 14 controlled control VBN cord-015021-pol2qm74 6283 15 randomized randomized JJ cord-015021-pol2qm74 6283 16 studies study NNS cord-015021-pol2qm74 6283 17 on on IN cord-015021-pol2qm74 6283 18 surgical surgical JJ cord-015021-pol2qm74 6283 19 patients patient NNS cord-015021-pol2qm74 6283 20 suffering suffer VBG cord-015021-pol2qm74 6283 21 from from IN cord-015021-pol2qm74 6283 22 multiple multiple JJ cord-015021-pol2qm74 6283 23 trauma trauma NN cord-015021-pol2qm74 6283 24 or or CC cord-015021-pol2qm74 6283 25 severe severe JJ cord-015021-pol2qm74 6283 26 sepsis sepsis NN cord-015021-pol2qm74 6283 27 . . . cord-015021-pol2qm74 6284 1 In in IN cord-015021-pol2qm74 6284 2 control control NN cord-015021-pol2qm74 6284 3 patients patient NNS cord-015021-pol2qm74 6284 4 we -PRON- PRP cord-015021-pol2qm74 6284 5 could could MD cord-015021-pol2qm74 6284 6 clearly clearly RB cord-015021-pol2qm74 6284 7 demonstrate demonstrate VB cord-015021-pol2qm74 6284 8 the the DT cord-015021-pol2qm74 6284 9 sequential sequential JJ cord-015021-pol2qm74 6284 10 appearance appearance NN cord-015021-pol2qm74 6284 11 of of IN cord-015021-pol2qm74 6284 12 proteinase proteinase NN cord-015021-pol2qm74 6284 13 / / SYM cord-015021-pol2qm74 6284 14 serpin serpin NN cord-015021-pol2qm74 6284 15 - - HYPH cord-015021-pol2qm74 6284 16 complexes complex NNS cord-015021-pol2qm74 6284 17 ( ( -LRB- cord-015021-pol2qm74 6284 18 Fa Fa NNP cord-015021-pol2qm74 6284 19 1PI 1PI NNP cord-015021-pol2qm74 6284 20 , , , cord-015021-pol2qm74 6284 21 TAT TAT NNP cord-015021-pol2qm74 6284 22 ) ) -RRB- cord-015021-pol2qm74 6284 23 , , , cord-015021-pol2qm74 6284 24 cytokines cytokine NNS cord-015021-pol2qm74 6284 25 ( ( -LRB- cord-015021-pol2qm74 6284 26 IL-8 IL-8 NNP cord-015021-pol2qm74 6284 27 , , , cord-015021-pol2qm74 6284 28 IL-6 IL-6 NNP cord-015021-pol2qm74 6284 29 ) ) -RRB- cord-015021-pol2qm74 6284 30 , , , cord-015021-pol2qm74 6284 31 and and CC cord-015021-pol2qm74 6284 32 soluble soluble JJ cord-015021-pol2qm74 6284 33 intercellular intercellular JJ cord-015021-pol2qm74 6284 34 adh6sion adh6sion NN cord-015021-pol2qm74 6284 35 molecules molecule NNS cord-015021-pol2qm74 6284 36 ( ( -LRB- cord-015021-pol2qm74 6284 37 ICAM ICAM NNP cord-015021-pol2qm74 6284 38 , , , cord-015021-pol2qm74 6284 39 ELAN ELAN NNP cord-015021-pol2qm74 6284 40 , , , cord-015021-pol2qm74 6284 41 P p NN cord-015021-pol2qm74 6284 42 - - HYPH cord-015021-pol2qm74 6284 43 selectin selectin NNP cord-015021-pol2qm74 6284 44 ) ) -RRB- cord-015021-pol2qm74 6284 45 in in IN cord-015021-pol2qm74 6284 46 the the DT cord-015021-pol2qm74 6284 47 circulation circulation NN cord-015021-pol2qm74 6284 48 . . . cord-015021-pol2qm74 6285 1 These these DT cord-015021-pol2qm74 6285 2 factors factor NNS cord-015021-pol2qm74 6285 3 turned turn VBD cord-015021-pol2qm74 6285 4 out out RP cord-015021-pol2qm74 6285 5 to to TO cord-015021-pol2qm74 6285 6 be be VB cord-015021-pol2qm74 6285 7 a a DT cord-015021-pol2qm74 6285 8 helpful helpful JJ cord-015021-pol2qm74 6285 9 tool tool NN cord-015021-pol2qm74 6285 10 for for IN cord-015021-pol2qm74 6285 11 early early JJ cord-015021-pol2qm74 6285 12 diagnosis diagnosis NN cord-015021-pol2qm74 6285 13 and and CC cord-015021-pol2qm74 6285 14 prognosis prognosis NN cord-015021-pol2qm74 6285 15 of of IN cord-015021-pol2qm74 6285 16 forthcoming forthcoming JJ cord-015021-pol2qm74 6285 17 organ organ NN cord-015021-pol2qm74 6285 18 dysfunctions dysfunction NNS cord-015021-pol2qm74 6285 19 . . . cord-015021-pol2qm74 6286 1 Interestingly interestingly RB cord-015021-pol2qm74 6286 2 , , , cord-015021-pol2qm74 6286 3 m m NNP cord-015021-pol2qm74 6286 4 AT AT NNP cord-015021-pol2qm74 6286 5 III III NNP cord-015021-pol2qm74 6286 6 - - HYPH cord-015021-pol2qm74 6286 7 treated treat VBN cord-015021-pol2qm74 6286 8 patients patient NNS cord-015021-pol2qm74 6286 9 a a DT cord-015021-pol2qm74 6286 10 significantly significantly RB cord-015021-pol2qm74 6286 11 reduced reduce VBN cord-015021-pol2qm74 6286 12 release release NN cord-015021-pol2qm74 6286 13 / / SYM cord-015021-pol2qm74 6286 14 production production NN cord-015021-pol2qm74 6286 15 of of IN cord-015021-pol2qm74 6286 16 inflammatory inflammatory JJ cord-015021-pol2qm74 6286 17 mediators mediator NNS cord-015021-pol2qm74 6286 18 became become VBD cord-015021-pol2qm74 6286 19 obvious obvious JJ cord-015021-pol2qm74 6286 20 concomitant concomitant JJ cord-015021-pol2qm74 6286 21 with with IN cord-015021-pol2qm74 6286 22 the the DT cord-015021-pol2qm74 6286 23 improved improve VBN cord-015021-pol2qm74 6286 24 clinical clinical JJ cord-015021-pol2qm74 6286 25 course course NN cord-015021-pol2qm74 6286 26 in in IN cord-015021-pol2qm74 6286 27 comparision comparision NN cord-015021-pol2qm74 6286 28 to to IN cord-015021-pol2qm74 6286 29 an an DT cord-015021-pol2qm74 6286 30 increasing increase VBG cord-015021-pol2qm74 6286 31 deterioration deterioration NN cord-015021-pol2qm74 6286 32 in in IN cord-015021-pol2qm74 6286 33 control control NN cord-015021-pol2qm74 6286 34 patients patient NNS cord-015021-pol2qm74 6286 35 . . . cord-015021-pol2qm74 6287 1 Soluble soluble JJ cord-015021-pol2qm74 6287 2 mediators mediator NNS cord-015021-pol2qm74 6287 3 of of IN cord-015021-pol2qm74 6287 4 inflammation inflammation NN cord-015021-pol2qm74 6287 5 are be VBP cord-015021-pol2qm74 6287 6 cytokines cytokine NNS cord-015021-pol2qm74 6287 7 ( ( -LRB- cord-015021-pol2qm74 6287 8 e.g. e.g. RB cord-015021-pol2qm74 6287 9 IL-1 IL-1 NNP cord-015021-pol2qm74 6287 10 , , , cord-015021-pol2qm74 6287 11 IL-6 IL-6 NNP cord-015021-pol2qm74 6287 12 and and CC cord-015021-pol2qm74 6287 13 TNFe TNFe NNP cord-015021-pol2qm74 6287 14 ) ) -RRB- cord-015021-pol2qm74 6287 15 as as RB cord-015021-pol2qm74 6287 16 well well RB cord-015021-pol2qm74 6287 17 as as IN cord-015021-pol2qm74 6287 18 breakdown breakdown NN cord-015021-pol2qm74 6287 19 products product NNS cord-015021-pol2qm74 6287 20 of of IN cord-015021-pol2qm74 6287 21 complement complement NN cord-015021-pol2qm74 6287 22 proteins protein NNS cord-015021-pol2qm74 6287 23 ( ( -LRB- cord-015021-pol2qm74 6287 24 e.g. e.g. IN cord-015021-pol2qm74 6287 25 C5a C5a NNS cord-015021-pol2qm74 6287 26 and and CC cord-015021-pol2qm74 6287 27 terminal terminal NN cord-015021-pol2qm74 6287 28 complement complement NN cord-015021-pol2qm74 6287 29 complex complex NN cord-015021-pol2qm74 6287 30 ) ) -RRB- cord-015021-pol2qm74 6287 31 . . . cord-015021-pol2qm74 6288 1 Therefore therefore RB cord-015021-pol2qm74 6288 2 , , , cord-015021-pol2qm74 6288 3 attenuation attenuation NN cord-015021-pol2qm74 6288 4 of of IN cord-015021-pol2qm74 6288 5 both both DT cord-015021-pol2qm74 6288 6 , , , cord-015021-pol2qm74 6288 7 release release NN cord-015021-pol2qm74 6288 8 and and CC cord-015021-pol2qm74 6288 9 generation generation NN cord-015021-pol2qm74 6288 10 of of IN cord-015021-pol2qm74 6288 11 these these DT cord-015021-pol2qm74 6288 12 synergistically synergistically RB cord-015021-pol2qm74 6288 13 functioning function VBG cord-015021-pol2qm74 6288 14 mediators mediator NNS cord-015021-pol2qm74 6288 15 together together RB cord-015021-pol2qm74 6288 16 with with IN cord-015021-pol2qm74 6288 17 stimulation stimulation NN cord-015021-pol2qm74 6288 18 of of IN cord-015021-pol2qm74 6288 19 release release NN cord-015021-pol2qm74 6288 20 of of IN cord-015021-pol2qm74 6288 21 antagonists antagonist NNS cord-015021-pol2qm74 6288 22 including include VBG cord-015021-pol2qm74 6288 23 soluble soluble JJ cord-015021-pol2qm74 6288 24 forms form NNS cord-015021-pol2qm74 6288 25 of of IN cord-015021-pol2qm74 6288 26 receptors receptor NNS cord-015021-pol2qm74 6288 27 are be VBP cord-015021-pol2qm74 6288 28 potentially potentially RB cord-015021-pol2qm74 6288 29 beneficial beneficial JJ cord-015021-pol2qm74 6288 30 in in IN cord-015021-pol2qm74 6288 31 all all DT cord-015021-pol2qm74 6288 32 kind kind NN cord-015021-pol2qm74 6288 33 of of IN cord-015021-pol2qm74 6288 34 inflammatory inflammatory JJ cord-015021-pol2qm74 6288 35 diseases disease NNS cord-015021-pol2qm74 6288 36 . . . cord-015021-pol2qm74 6289 1 Intravenous intravenous JJ cord-015021-pol2qm74 6289 2 immunoglobulins immunoglobulin NNS cord-015021-pol2qm74 6289 3 ( ( -LRB- cord-015021-pol2qm74 6289 4 IVIGs ivig NNS cord-015021-pol2qm74 6289 5 ) ) -RRB- cord-015021-pol2qm74 6289 6 are be VBP cord-015021-pol2qm74 6289 7 known know VBN cord-015021-pol2qm74 6289 8 to to TO cord-015021-pol2qm74 6289 9 have have VB cord-015021-pol2qm74 6289 10 an an DT cord-015021-pol2qm74 6289 11 anti anti JJ cord-015021-pol2qm74 6289 12 - - JJ cord-015021-pol2qm74 6289 13 inflammatory inflammatory JJ cord-015021-pol2qm74 6289 14 effect effect NN cord-015021-pol2qm74 6289 15 in in IN cord-015021-pol2qm74 6289 16 humans human NNS cord-015021-pol2qm74 6289 17 ( ( -LRB- cord-015021-pol2qm74 6289 18 NIH NIH NNP cord-015021-pol2qm74 6289 19 Consensus Consensus NNP cord-015021-pol2qm74 6289 20 Conference Conference NNP cord-015021-pol2qm74 6289 21 on on IN cord-015021-pol2qm74 6289 22 WIG WIG NNP cord-015021-pol2qm74 6289 23 , , , cord-015021-pol2qm74 6289 24 1990 1990 CD cord-015021-pol2qm74 6289 25 ) ) -RRB- cord-015021-pol2qm74 6289 26 . . . cord-015021-pol2qm74 6290 1 The the DT cord-015021-pol2qm74 6290 2 mechanism mechanism NN cord-015021-pol2qm74 6290 3 of of IN cord-015021-pol2qm74 6290 4 action action NN cord-015021-pol2qm74 6290 5 becomes become VBZ cord-015021-pol2qm74 6290 6 more more RBR cord-015021-pol2qm74 6290 7 and and CC cord-015021-pol2qm74 6290 8 more more RBR cord-015021-pol2qm74 6290 9 clear clear JJ cord-015021-pol2qm74 6290 10 . . . cord-015021-pol2qm74 6291 1 In in IN cord-015021-pol2qm74 6291 2 single single JJ cord-015021-pol2qm74 6291 3 cells cell NNS cord-015021-pol2qm74 6291 4 stimulated stimulate VBN cord-015021-pol2qm74 6291 5 by by IN cord-015021-pol2qm74 6291 6 anti anti JJ cord-015021-pol2qm74 6291 7 - - JJ cord-015021-pol2qm74 6291 8 CD3 cd3 JJ cord-015021-pol2qm74 6291 9 mAb mab NN cord-015021-pol2qm74 6291 10 WIG WIG NNP cord-015021-pol2qm74 6291 11 was be VBD cord-015021-pol2qm74 6291 12 able able JJ cord-015021-pol2qm74 6291 13 to to TO cord-015021-pol2qm74 6291 14 down down VB cord-015021-pol2qm74 6291 15 - - HYPH cord-015021-pol2qm74 6291 16 regulate regulate VB cord-015021-pol2qm74 6291 17 production production NN cord-015021-pol2qm74 6291 18 of of IN cord-015021-pol2qm74 6291 19 IL-2 IL-2 NNP cord-015021-pol2qm74 6291 20 , , , cord-015021-pol2qm74 6291 21 IL-10 IL-10 NNP cord-015021-pol2qm74 6291 22 , , , cord-015021-pol2qm74 6291 23 IFN% IFN% NNP cord-015021-pol2qm74 6291 24 and and CC cord-015021-pol2qm74 6291 25 TNFJ~ TNFJ~ NNP cord-015021-pol2qm74 6291 26 significantly significantly RB cord-015021-pol2qm74 6291 27 . . . cord-015021-pol2qm74 6292 1 IgG IgG NNP cord-015021-pol2qm74 6292 2 coated coat VBD cord-015021-pol2qm74 6292 3 solid solid JJ cord-015021-pol2qm74 6292 4 - - HYPH cord-015021-pol2qm74 6292 5 phase phase NN cord-015021-pol2qm74 6292 6 stimulates stimulate VBZ cord-015021-pol2qm74 6292 7 release release NN cord-015021-pol2qm74 6292 8 from from IN cord-015021-pol2qm74 6292 9 monocytes monocyte NNS cord-015021-pol2qm74 6292 10 of of IN cord-015021-pol2qm74 6292 11 interleukin-1 interleukin-1 NNP cord-015021-pol2qm74 6292 12 receptor receptor NN cord-015021-pol2qm74 6292 13 antagonist antagonist NN cord-015021-pol2qm74 6292 14 ( ( -LRB- cord-015021-pol2qm74 6292 15 IL IL NNP cord-015021-pol2qm74 6292 16 - - HYPH cord-015021-pol2qm74 6292 17 lra lra NNP cord-015021-pol2qm74 6292 18 ) ) -RRB- cord-015021-pol2qm74 6292 19 but but CC cord-015021-pol2qm74 6292 20 not not RB cord-015021-pol2qm74 6292 21 of of IN cord-015021-pol2qm74 6292 22 IL-1 IL-1 NNP cord-015021-pol2qm74 6292 23 ; ; : cord-015021-pol2qm74 6292 24 this this DT cord-015021-pol2qm74 6292 25 observation observation NN cord-015021-pol2qm74 6292 26 is be VBZ cord-015021-pol2qm74 6292 27 very very RB cord-015021-pol2qm74 6292 28 much much RB cord-015021-pol2qm74 6292 29 in in IN cord-015021-pol2qm74 6292 30 contrast contrast NN cord-015021-pol2qm74 6292 31 to to IN cord-015021-pol2qm74 6292 32 the the DT cord-015021-pol2qm74 6292 33 effect effect NN cord-015021-pol2qm74 6292 34 of of IN cord-015021-pol2qm74 6292 35 endotoxin endotoxin NN cord-015021-pol2qm74 6292 36 in in IN cord-015021-pol2qm74 6292 37 the the DT cord-015021-pol2qm74 6292 38 same same JJ cord-015021-pol2qm74 6292 39 in in IN cord-015021-pol2qm74 6292 40 vitro vitro FW cord-015021-pol2qm74 6292 41 system system NN cord-015021-pol2qm74 6292 42 . . . cord-015021-pol2qm74 6293 1 Furthermore furthermore RB cord-015021-pol2qm74 6293 2 , , , cord-015021-pol2qm74 6293 3 naturally naturally RB cord-015021-pol2qm74 6293 4 occurring occur VBG cord-015021-pol2qm74 6293 5 anti anti JJ cord-015021-pol2qm74 6293 6 - - JJ cord-015021-pol2qm74 6293 7 cytokine cytokine JJ cord-015021-pol2qm74 6293 8 antibodies antibody NNS cord-015021-pol2qm74 6293 9 can can MD cord-015021-pol2qm74 6293 10 be be VB cord-015021-pol2qm74 6293 11 demonstrated demonstrate VBN cord-015021-pol2qm74 6293 12 in in IN cord-015021-pol2qm74 6293 13 apparently apparently RB cord-015021-pol2qm74 6293 14 healthy healthy JJ cord-015021-pol2qm74 6293 15 individuals individual NNS cord-015021-pol2qm74 6293 16 and and CC cord-015021-pol2qm74 6293 17 in in IN cord-015021-pol2qm74 6293 18 WIG wig NN cord-015021-pol2qm74 6293 19 prepared prepare VBN cord-015021-pol2qm74 6293 20 from from IN cord-015021-pol2qm74 6293 21 plasma plasma NN cord-015021-pol2qm74 6293 22 pools pool NNS cord-015021-pol2qm74 6293 23 . . . cord-015021-pol2qm74 6294 1 Some some DT cord-015021-pol2qm74 6294 2 of of IN cord-015021-pol2qm74 6294 3 these these DT cord-015021-pol2qm74 6294 4 antibodies antibody NNS cord-015021-pol2qm74 6294 5 can can MD cord-015021-pol2qm74 6294 6 be be VB cord-015021-pol2qm74 6294 7 detected detect VBN cord-015021-pol2qm74 6294 8 by by IN cord-015021-pol2qm74 6294 9 antigen antigen NN cord-015021-pol2qm74 6294 10 / / SYM cord-015021-pol2qm74 6294 11 antibody antibody NN cord-015021-pol2qm74 6294 12 reactions reaction NNS cord-015021-pol2qm74 6294 13 in in IN cord-015021-pol2qm74 6294 14 fluid fluid JJ cord-015021-pol2qm74 6294 15 phase phase NN cord-015021-pol2qm74 6294 16 ( ( -LRB- cord-015021-pol2qm74 6294 17 anti anti JJ cord-015021-pol2qm74 6294 18 - - JJ cord-015021-pol2qm74 6294 19 lL ll JJ cord-015021-pol2qm74 6294 20 - - HYPH cord-015021-pol2qm74 6294 21 le le NNP cord-015021-pol2qm74 6294 22 , , , cord-015021-pol2qm74 6294 23 anti anti NNP cord-015021-pol2qm74 6294 24 - - NNP cord-015021-pol2qm74 6294 25 IL-6 IL-6 NNP cord-015021-pol2qm74 6294 26 ) ) -RRB- cord-015021-pol2qm74 6294 27 , , , cord-015021-pol2qm74 6294 28 some some DT cord-015021-pol2qm74 6294 29 only only RB cord-015021-pol2qm74 6294 30 by by IN cord-015021-pol2qm74 6294 31 solid solid JJ cord-015021-pol2qm74 6294 32 - - HYPH cord-015021-pol2qm74 6294 33 phase phase NN cord-015021-pol2qm74 6294 34 detection detection NN cord-015021-pol2qm74 6294 35 systems system NNS cord-015021-pol2qm74 6294 36 ( ( -LRB- cord-015021-pol2qm74 6294 37 anti anti NNS cord-015021-pol2qm74 6294 38 - - JJ cord-015021-pol2qm74 6294 39 lL-8 ll-8 JJ cord-015021-pol2qm74 6294 40 , , , cord-015021-pol2qm74 6294 41 anti anti JJ cord-015021-pol2qm74 6294 42 - - JJ cord-015021-pol2qm74 6294 43 IFN% ifn% JJ cord-015021-pol2qm74 6294 44 anti anti JJ cord-015021-pol2qm74 6294 45 - - JJ cord-015021-pol2qm74 6294 46 TNFc TNFc NNS cord-015021-pol2qm74 6294 47 0 0 CD cord-015021-pol2qm74 6294 48 . . . cord-015021-pol2qm74 6295 1 Infusion infusion NN cord-015021-pol2qm74 6295 2 of of IN cord-015021-pol2qm74 6295 3 WIG wig NN cord-015021-pol2qm74 6295 4 to to IN cord-015021-pol2qm74 6295 5 patients patient NNS cord-015021-pol2qm74 6295 6 suffering suffer VBG cord-015021-pol2qm74 6295 7 from from IN cord-015021-pol2qm74 6295 8 inflammatory inflammatory JJ cord-015021-pol2qm74 6295 9 disorders disorder NNS cord-015021-pol2qm74 6295 10 have have VBP cord-015021-pol2qm74 6295 11 resulted result VBN cord-015021-pol2qm74 6295 12 in in IN cord-015021-pol2qm74 6295 13 a a DT cord-015021-pol2qm74 6295 14 decrease decrease NN cord-015021-pol2qm74 6295 15 in in IN cord-015021-pol2qm74 6295 16 IL-6 IL-6 NNP cord-015021-pol2qm74 6295 17 in in IN cord-015021-pol2qm74 6295 18 circulation circulation NN cord-015021-pol2qm74 6295 19 . . . cord-015021-pol2qm74 6296 1 During during IN cord-015021-pol2qm74 6296 2 infusion infusion NN cord-015021-pol2qm74 6296 3 WIG wig NN cord-015021-pol2qm74 6296 4 might may MD cord-015021-pol2qm74 6296 5 induce induce VB cord-015021-pol2qm74 6296 6 an an DT cord-015021-pol2qm74 6296 7 acute acute JJ cord-015021-pol2qm74 6296 8 but but CC cord-015021-pol2qm74 6296 9 transient transient JJ cord-015021-pol2qm74 6296 10 rise rise NN cord-015021-pol2qm74 6296 11 of of IN cord-015021-pol2qm74 6296 12 TNFo~ tnfo~ NN cord-015021-pol2qm74 6296 13 , , , cord-015021-pol2qm74 6296 14 IL-6 IL-6 NNP cord-015021-pol2qm74 6296 15 , , , cord-015021-pol2qm74 6296 16 and and CC cord-015021-pol2qm74 6297 1 IL-8 IL-8 NNP cord-015021-pol2qm74 6297 2 . . . cord-015021-pol2qm74 6298 1 Self self NN cord-015021-pol2qm74 6298 2 limitiation limitiation NN cord-015021-pol2qm74 6298 3 of of IN cord-015021-pol2qm74 6298 4 this this DT cord-015021-pol2qm74 6298 5 process process NN cord-015021-pol2qm74 6298 6 might may MD cord-015021-pol2qm74 6298 7 be be VB cord-015021-pol2qm74 6298 8 due due JJ cord-015021-pol2qm74 6298 9 to to IN cord-015021-pol2qm74 6298 10 demonstrable demonstrable JJ cord-015021-pol2qm74 6298 11 instant instant JJ cord-015021-pol2qm74 6298 12 release release NN cord-015021-pol2qm74 6298 13 of of IN cord-015021-pol2qm74 6298 14 IL-1 IL-1 NNP cord-015021-pol2qm74 6298 15 ra ra NNP cord-015021-pol2qm74 6298 16 and and CC cord-015021-pol2qm74 6298 17 soluble soluble JJ cord-015021-pol2qm74 6298 18 TNFo~ TNFo~ NNP cord-015021-pol2qm74 6298 19 receptors receptor NNS cord-015021-pol2qm74 6298 20 . . . cord-015021-pol2qm74 6299 1 In in IN cord-015021-pol2qm74 6299 2 vitro vitro FW cord-015021-pol2qm74 6299 3 IVIG IVIG NNP cord-015021-pol2qm74 6299 4 has have VBZ cord-015021-pol2qm74 6299 5 also also RB cord-015021-pol2qm74 6299 6 been be VBN cord-015021-pol2qm74 6299 7 shown show VBN cord-015021-pol2qm74 6299 8 to to TO cord-015021-pol2qm74 6299 9 attenuate attenuate VB cord-015021-pol2qm74 6299 10 complement complement JJ cord-015021-pol2qm74 6299 11 activation activation NN cord-015021-pol2qm74 6299 12 via via IN cord-015021-pol2qm74 6299 13 the the DT cord-015021-pol2qm74 6299 14 classical classical JJ cord-015021-pol2qm74 6299 15 pathway pathway NN cord-015021-pol2qm74 6299 16 . . . cord-015021-pol2qm74 6300 1 Furthermore furthermore RB cord-015021-pol2qm74 6300 2 , , , cord-015021-pol2qm74 6300 3 acid acid NNP cord-015021-pol2qm74 6300 4 haemolysis haemolysis NN cord-015021-pol2qm74 6300 5 of of IN cord-015021-pol2qm74 6300 6 erythrocytes erythrocyte NNS cord-015021-pol2qm74 6300 7 in in IN cord-015021-pol2qm74 6300 8 paroxysmal paroxysmal JJ cord-015021-pol2qm74 6300 9 nocturnal nocturnal JJ cord-015021-pol2qm74 6300 10 haemoglobinuria haemoglobinuria NNS cord-015021-pol2qm74 6300 11 could could MD cord-015021-pol2qm74 6300 12 partially partially RB cord-015021-pol2qm74 6300 13 be be VB cord-015021-pol2qm74 6300 14 prevented prevent VBN cord-015021-pol2qm74 6300 15 by by IN cord-015021-pol2qm74 6300 16 IVIG IVIG NNP cord-015021-pol2qm74 6300 17 . . . cord-015021-pol2qm74 6301 1 IVIG IVIG NNP cord-015021-pol2qm74 6301 2 was be VBD cord-015021-pol2qm74 6301 3 able able JJ cord-015021-pol2qm74 6301 4 to to TO cord-015021-pol2qm74 6301 5 attenuate attenuate VB cord-015021-pol2qm74 6301 6 Forssman Forssman NNP cord-015021-pol2qm74 6301 7 shock shock NN cord-015021-pol2qm74 6301 8 in in IN cord-015021-pol2qm74 6301 9 guinea guinea NN cord-015021-pol2qm74 6301 10 pigs pig NNS cord-015021-pol2qm74 6301 11 . . . cord-015021-pol2qm74 6302 1 We -PRON- PRP cord-015021-pol2qm74 6302 2 have have VBP cord-015021-pol2qm74 6302 3 seen see VBN cord-015021-pol2qm74 6302 4 a a DT cord-015021-pol2qm74 6302 5 patient patient NN cord-015021-pol2qm74 6302 6 with with IN cord-015021-pol2qm74 6302 7 congenitally congenitally RB cord-015021-pol2qm74 6302 8 elevated elevated JJ cord-015021-pol2qm74 6302 9 turnover turnover NN cord-015021-pol2qm74 6302 10 of of IN cord-015021-pol2qm74 6302 11 alternative alternative JJ cord-015021-pol2qm74 6302 12 pathway pathway NN cord-015021-pol2qm74 6302 13 of of IN cord-015021-pol2qm74 6302 14 complement complement NN cord-015021-pol2qm74 6302 15 who who WP cord-015021-pol2qm74 6302 16 repeatedly repeatedly RB cord-015021-pol2qm74 6302 17 showed show VBD cord-015021-pol2qm74 6302 18 an an DT cord-015021-pol2qm74 6302 19 increase increase NN cord-015021-pol2qm74 6302 20 of of IN cord-015021-pol2qm74 6302 21 haemolytic haemolytic JJ cord-015021-pol2qm74 6302 22 titres titre NNS cord-015021-pol2qm74 6302 23 after after IN cord-015021-pol2qm74 6302 24 administration administration NN cord-015021-pol2qm74 6302 25 of of IN cord-015021-pol2qm74 6302 26 IVIG IVIG NNP cord-015021-pol2qm74 6302 27 . . . cord-015021-pol2qm74 6303 1 Thus thus RB cord-015021-pol2qm74 6303 2 , , , cord-015021-pol2qm74 6303 3 WIGs wig NNS cord-015021-pol2qm74 6303 4 apparently apparently RB cord-015021-pol2qm74 6303 5 have have VBP cord-015021-pol2qm74 6303 6 multiple multiple JJ cord-015021-pol2qm74 6303 7 potencies potency NNS cord-015021-pol2qm74 6303 8 including include VBG cord-015021-pol2qm74 6303 9 attenuation attenuation NN cord-015021-pol2qm74 6303 10 of of IN cord-015021-pol2qm74 6303 11 soluble soluble JJ cord-015021-pol2qm74 6303 12 mediators mediator NNS cord-015021-pol2qm74 6303 13 of of IN cord-015021-pol2qm74 6303 14 inflammation inflammation NN cord-015021-pol2qm74 6303 15 and and CC cord-015021-pol2qm74 6303 16 might may MD cord-015021-pol2qm74 6303 17 therefore therefore RB cord-015021-pol2qm74 6303 18 be be VB cord-015021-pol2qm74 6303 19 of of IN cord-015021-pol2qm74 6303 20 benefit benefit NN cord-015021-pol2qm74 6303 21 in in IN cord-015021-pol2qm74 6303 22 trauma trauma NN cord-015021-pol2qm74 6303 23 , , , cord-015021-pol2qm74 6303 24 shock shock NN cord-015021-pol2qm74 6303 25 , , , cord-015021-pol2qm74 6303 26 and and CC cord-015021-pol2qm74 6303 27 sepsis sepsis NN cord-015021-pol2qm74 6303 28 . . . cord-015021-pol2qm74 6304 1 Significance significance NN cord-015021-pol2qm74 6304 2 of of IN cord-015021-pol2qm74 6304 3 sinusoidal sinusoidal JJ cord-015021-pol2qm74 6304 4 liuing liuing NN cord-015021-pol2qm74 6304 5 cells cell NNS cord-015021-pol2qm74 6304 6 and and CC cord-015021-pol2qm74 6304 7 of of IN cord-015021-pol2qm74 6304 8 humoral humoral JJ cord-015021-pol2qm74 6304 9 factors factor NNS cord-015021-pol2qm74 6304 10 on on IN cord-015021-pol2qm74 6304 11 hepatic hepatic JJ cord-015021-pol2qm74 6304 12 function function NN cord-015021-pol2qm74 6304 13 following follow VBG cord-015021-pol2qm74 6304 14 sepsis sepsis NN cord-015021-pol2qm74 6304 15 and and CC cord-015021-pol2qm74 6304 16 major major JJ cord-015021-pol2qm74 6304 17 surgery surgery NN cord-015021-pol2qm74 6305 1 Hirata Hirata NNP cord-015021-pol2qm74 6305 2 K K NNP cord-015021-pol2qm74 6305 3 , , , cord-015021-pol2qm74 6305 4 Katsuramaki Katsuramaki NNP cord-015021-pol2qm74 6305 5 T T NNP cord-015021-pol2qm74 6305 6 , , , cord-015021-pol2qm74 6305 7 Yamaguchi Yamaguchi NNP cord-015021-pol2qm74 6305 8 H H NNP cord-015021-pol2qm74 6305 9 , , , cord-015021-pol2qm74 6305 10 Mukaiya Mukaiya NNP cord-015021-pol2qm74 6305 11 M M NNP cord-015021-pol2qm74 6305 12 , , , cord-015021-pol2qm74 6305 13 Yamashiro Yamashiro NNP cord-015021-pol2qm74 6305 14 K. K. NNP cord-015021-pol2qm74 6305 15 Regeneration regeneration NN cord-015021-pol2qm74 6305 16 of of IN cord-015021-pol2qm74 6305 17 the the DT cord-015021-pol2qm74 6305 18 liver liver NN cord-015021-pol2qm74 6305 19 after after IN cord-015021-pol2qm74 6305 20 hepatic hepatic JJ cord-015021-pol2qm74 6305 21 necrosis necrosis NN cord-015021-pol2qm74 6305 22 or or CC cord-015021-pol2qm74 6305 23 partial partial JJ cord-015021-pol2qm74 6305 24 removal removal NN cord-015021-pol2qm74 6305 25 has have VBZ cord-015021-pol2qm74 6305 26 been be VBN cord-015021-pol2qm74 6305 27 extensively extensively RB cord-015021-pol2qm74 6305 28 studied study VBN cord-015021-pol2qm74 6305 29 , , , cord-015021-pol2qm74 6305 30 but but CC cord-015021-pol2qm74 6305 31 uncontrolled uncontrolled JJ cord-015021-pol2qm74 6305 32 mechanisms mechanism NNS cord-015021-pol2qm74 6305 33 to to IN cord-015021-pol2qm74 6305 34 irreversible irreversible JJ cord-015021-pol2qm74 6305 35 hepatic hepatic JJ cord-015021-pol2qm74 6305 36 failure failure NN cord-015021-pol2qm74 6305 37 following follow VBG cord-015021-pol2qm74 6305 38 sepsis sepsis NN cord-015021-pol2qm74 6305 39 or or CC cord-015021-pol2qm74 6305 40 major major JJ cord-015021-pol2qm74 6305 41 surgery surgery NN cord-015021-pol2qm74 6305 42 of of IN cord-015021-pol2qm74 6305 43 liver liver NN cord-015021-pol2qm74 6305 44 or or CC cord-015021-pol2qm74 6305 45 with with IN cord-015021-pol2qm74 6305 46 hepatic hepatic JJ cord-015021-pol2qm74 6305 47 dysfunction dysfunction NN cord-015021-pol2qm74 6305 48 have have VBP cord-015021-pol2qm74 6305 49 so so RB cord-015021-pol2qm74 6305 50 far far RB cord-015021-pol2qm74 6305 51 not not RB cord-015021-pol2qm74 6305 52 been be VBN cord-015021-pol2qm74 6305 53 well well RB cord-015021-pol2qm74 6305 54 documented document VBN cord-015021-pol2qm74 6305 55 . . . cord-015021-pol2qm74 6306 1 We -PRON- PRP cord-015021-pol2qm74 6306 2 suggested suggest VBD cord-015021-pol2qm74 6306 3 the the DT cord-015021-pol2qm74 6306 4 importance importance NN cord-015021-pol2qm74 6306 5 of of IN cord-015021-pol2qm74 6306 6 the the DT cord-015021-pol2qm74 6306 7 intrasinusoidal intrasinusoidal JJ cord-015021-pol2qm74 6306 8 aggregation aggregation NN cord-015021-pol2qm74 6306 9 between between IN cord-015021-pol2qm74 6306 10 sinusoidal sinusoidal JJ cord-015021-pol2qm74 6306 11 lining lining NN cord-015021-pol2qm74 6306 12 cells cell NNS cord-015021-pol2qm74 6306 13 and and CC cord-015021-pol2qm74 6306 14 intrasinusoidal intrasinusoidal NNP cord-015021-pol2qm74 6306 15 running run VBG cord-015021-pol2qm74 6306 16 ceils ceils NNP cord-015021-pol2qm74 6306 17 in in IN cord-015021-pol2qm74 6306 18 the the DT cord-015021-pol2qm74 6306 19 mechanisms mechanism NNS cord-015021-pol2qm74 6306 20 of of IN cord-015021-pol2qm74 6306 21 hepatocyte hepatocyte NN cord-015021-pol2qm74 6306 22 dysfunction dysfunction NN cord-015021-pol2qm74 6306 23 . . . cord-015021-pol2qm74 6307 1 Thus thus RB cord-015021-pol2qm74 6307 2 , , , cord-015021-pol2qm74 6307 3 the the DT cord-015021-pol2qm74 6307 4 purposes purpose NNS cord-015021-pol2qm74 6307 5 of of IN cord-015021-pol2qm74 6307 6 this this DT cord-015021-pol2qm74 6307 7 study study NN cord-015021-pol2qm74 6307 8 was be VBD cord-015021-pol2qm74 6307 9 to to TO cord-015021-pol2qm74 6307 10 investigate investigate VB cord-015021-pol2qm74 6307 11 the the DT cord-015021-pol2qm74 6307 12 changes change NNS cord-015021-pol2qm74 6307 13 in in IN cord-015021-pol2qm74 6307 14 each each DT cord-015021-pol2qm74 6307 15 sinusoidal sinusoidal JJ cord-015021-pol2qm74 6307 16 lining lining NN cord-015021-pol2qm74 6307 17 cell cell NN cord-015021-pol2qm74 6307 18 during during IN cord-015021-pol2qm74 6307 19 this this DT cord-015021-pol2qm74 6307 20 process process NN cord-015021-pol2qm74 6307 21 and and CC cord-015021-pol2qm74 6307 22 the the DT cord-015021-pol2qm74 6307 23 effect effect NN cord-015021-pol2qm74 6307 24 of of IN cord-015021-pol2qm74 6307 25 cytokine cytokine NN cord-015021-pol2qm74 6307 26 on on IN cord-015021-pol2qm74 6307 27 hepatocyte hepatocyte NN cord-015021-pol2qm74 6307 28 under under IN cord-015021-pol2qm74 6307 29 various various JJ cord-015021-pol2qm74 6307 30 oxygenation oxygenation NN cord-015021-pol2qm74 6307 31 . . . cord-015021-pol2qm74 6308 1 [ [ -LRB- cord-015021-pol2qm74 6308 2 Materials material NNS cord-015021-pol2qm74 6308 3 and and CC cord-015021-pol2qm74 6308 4 Methods Methods NNPS cord-015021-pol2qm74 6308 5 ] ] -RRB- cord-015021-pol2qm74 6308 6 ( ( -LRB- cord-015021-pol2qm74 6308 7 1 1 LS cord-015021-pol2qm74 6308 8 ) ) -RRB- cord-015021-pol2qm74 6308 9 Clinical clinical JJ cord-015021-pol2qm74 6308 10 study study NN cord-015021-pol2qm74 6308 11 : : : cord-015021-pol2qm74 6309 1 Thirty thirty CD cord-015021-pol2qm74 6309 2 two two CD cord-015021-pol2qm74 6309 3 patients patient NNS cord-015021-pol2qm74 6309 4 with with IN cord-015021-pol2qm74 6309 5 histologically histologically RB cord-015021-pol2qm74 6309 6 proved prove VBN cord-015021-pol2qm74 6309 7 malignant malignant JJ cord-015021-pol2qm74 6309 8 tumor tumor NN cord-015021-pol2qm74 6309 9 underwent undergo VBD cord-015021-pol2qm74 6309 10 major major JJ cord-015021-pol2qm74 6309 11 hepatectomy hepatectomy NN cord-015021-pol2qm74 6309 12 were be VBD cord-015021-pol2qm74 6309 13 devided devide VBN cord-015021-pol2qm74 6309 14 in in IN cord-015021-pol2qm74 6309 15 two two CD cord-015021-pol2qm74 6309 16 groups group NNS cord-015021-pol2qm74 6309 17 , , , cord-015021-pol2qm74 6309 18 i_e i_e NNP cord-015021-pol2qm74 6309 19 . . . cord-015021-pol2qm74 6310 1 the the DT cord-015021-pol2qm74 6310 2 cirrhotic cirrhotic JJ cord-015021-pol2qm74 6310 3 liver liver NN cord-015021-pol2qm74 6310 4 group group NN cord-015021-pol2qm74 6310 5 and and CC cord-015021-pol2qm74 6310 6 the the DT cord-015021-pol2qm74 6310 7 non non JJ cord-015021-pol2qm74 6310 8 - - JJ cord-015021-pol2qm74 6310 9 cirrhotic cirrhotic JJ cord-015021-pol2qm74 6310 10 [ [ -LRB- cord-015021-pol2qm74 6310 11 Aver Aver NNP cord-015021-pol2qm74 6310 12 group group NN cord-015021-pol2qm74 6310 13 . . . cord-015021-pol2qm74 6311 1 Most Most JJS cord-015021-pol2qm74 6311 2 of of IN cord-015021-pol2qm74 6311 3 the the DT cord-015021-pol2qm74 6311 4 former former JJ cord-015021-pol2qm74 6311 5 were be VBD cord-015021-pol2qm74 6311 6 the the DT cord-015021-pol2qm74 6311 7 patients patient NNS cord-015021-pol2qm74 6311 8 with with IN cord-015021-pol2qm74 6311 9 hepatocellular hepatocellular JJ cord-015021-pol2qm74 6311 10 carcinoma carcinoma NN cord-015021-pol2qm74 6311 11 and and CC cord-015021-pol2qm74 6311 12 most most JJS cord-015021-pol2qm74 6311 13 of of IN cord-015021-pol2qm74 6311 14 the the DT cord-015021-pol2qm74 6311 15 latter latter JJ cord-015021-pol2qm74 6311 16 were be VBD cord-015021-pol2qm74 6311 17 the the DT cord-015021-pol2qm74 6311 18 patients patient NNS cord-015021-pol2qm74 6311 19 with with IN cord-015021-pol2qm74 6311 20 metastatic metastatic JJ cord-015021-pol2qm74 6311 21 carcinoma carcinoma NN cord-015021-pol2qm74 6311 22 of of IN cord-015021-pol2qm74 6311 23 colorectal colorectal JJ cord-015021-pol2qm74 6311 24 cancer cancer NN cord-015021-pol2qm74 6311 25 . . . cord-015021-pol2qm74 6312 1 Five five CD cord-015021-pol2qm74 6312 2 patients patient NNS cord-015021-pol2qm74 6312 3 were be VBD cord-015021-pol2qm74 6312 4 complicated complicated JJ cord-015021-pol2qm74 6312 5 septic septic JJ cord-015021-pol2qm74 6312 6 conditions condition NNS cord-015021-pol2qm74 6312 7 with with IN cord-015021-pol2qm74 6312 8 hepatic hepatic JJ cord-015021-pol2qm74 6312 9 failure failure NN cord-015021-pol2qm74 6312 10 . . . cord-015021-pol2qm74 6313 1 Following follow VBG cord-015021-pol2qm74 6313 2 operation operation NN cord-015021-pol2qm74 6313 3 in in IN cord-015021-pol2qm74 6313 4 each each DT cord-015021-pol2qm74 6313 5 patient patient NN cord-015021-pol2qm74 6313 6 , , , cord-015021-pol2qm74 6313 7 a a DT cord-015021-pol2qm74 6313 8 verous verous JJ cord-015021-pol2qm74 6313 9 blood blood NN cord-015021-pol2qm74 6313 10 sample sample NN cord-015021-pol2qm74 6313 11 was be VBD cord-015021-pol2qm74 6313 12 taken take VBN cord-015021-pol2qm74 6313 13 for for IN cord-015021-pol2qm74 6313 14 measurement measurement NN cord-015021-pol2qm74 6313 15 of of IN cord-015021-pol2qm74 6313 16 serum serum NN cord-015021-pol2qm74 6313 17 IL-1 IL-1 NNP cord-015021-pol2qm74 6313 18 , , , cord-015021-pol2qm74 6313 19 IL-6 IL-6 NNP cord-015021-pol2qm74 6313 20 , , , cord-015021-pol2qm74 6313 21 TNF TNF NNP cord-015021-pol2qm74 6313 22 and and CC cord-015021-pol2qm74 6313 23 C C NNP cord-015021-pol2qm74 6313 24 - - HYPH cord-015021-pol2qm74 6313 25 reactive reactive JJ cord-015021-pol2qm74 6313 26 protein protein NN cord-015021-pol2qm74 6313 27 concentration concentration NN cord-015021-pol2qm74 6313 28 . . . cord-015021-pol2qm74 6314 1 And and CC cord-015021-pol2qm74 6314 2 hepatic hepatic JJ cord-015021-pol2qm74 6314 3 biopsies biopsy NNS cord-015021-pol2qm74 6314 4 were be VBD cord-015021-pol2qm74 6314 5 sometimes sometimes RB cord-015021-pol2qm74 6314 6 undergone undergo VBN cord-015021-pol2qm74 6314 7 in in IN cord-015021-pol2qm74 6314 8 patients patient NNS cord-015021-pol2qm74 6314 9 with with IN cord-015021-pol2qm74 6314 10 anomalous anomalous JJ cord-015021-pol2qm74 6314 11 hepatic hepatic JJ cord-015021-pol2qm74 6314 12 function function NN cord-015021-pol2qm74 6314 13 . . . cord-015021-pol2qm74 6315 1 ( ( -LRB- cord-015021-pol2qm74 6315 2 2 2 LS cord-015021-pol2qm74 6315 3 ) ) -RRB- cord-015021-pol2qm74 6315 4 Experimental experimental JJ cord-015021-pol2qm74 6315 5 study study NN cord-015021-pol2qm74 6315 6 : : : cord-015021-pol2qm74 6315 7 Kupffer Kupffer NNP cord-015021-pol2qm74 6315 8 ceils ceil NNS cord-015021-pol2qm74 6315 9 , , , cord-015021-pol2qm74 6315 10 sinsoidal sinsoidal JJ cord-015021-pol2qm74 6315 11 endothelial endothelial JJ cord-015021-pol2qm74 6315 12 cells cell NNS cord-015021-pol2qm74 6315 13 and and CC cord-015021-pol2qm74 6315 14 hepatocytes hepatocyte NNS cord-015021-pol2qm74 6315 15 were be VBD cord-015021-pol2qm74 6315 16 separated separate VBN cord-015021-pol2qm74 6315 17 from from IN cord-015021-pol2qm74 6315 18 mouse mouse NN cord-015021-pol2qm74 6315 19 ( ( -LRB- cord-015021-pol2qm74 6315 20 C3HHeN C3HHeN NNP cord-015021-pol2qm74 6315 21 ) ) -RRB- cord-015021-pol2qm74 6315 22 liver liver NN cord-015021-pol2qm74 6315 23 . . . cord-015021-pol2qm74 6316 1 And and CC cord-015021-pol2qm74 6316 2 also also RB cord-015021-pol2qm74 6316 3 polymorphonuclear polymorphonuclear JJ cord-015021-pol2qm74 6316 4 cells cell NNS cord-015021-pol2qm74 6316 5 and and CC cord-015021-pol2qm74 6316 6 platelets platelet NNS cord-015021-pol2qm74 6316 7 were be VBD cord-015021-pol2qm74 6316 8 purified purify VBN cord-015021-pol2qm74 6316 9 from from IN cord-015021-pol2qm74 6316 10 blood blood NN cord-015021-pol2qm74 6316 11 and and CC cord-015021-pol2qm74 6316 12 peritoneal peritoneal JJ cord-015021-pol2qm74 6316 13 macrophages macrophage NNS cord-015021-pol2qm74 6316 14 were be VBD cord-015021-pol2qm74 6316 15 from from IN cord-015021-pol2qm74 6316 16 peritoneal peritoneal JJ cord-015021-pol2qm74 6316 17 cavity cavity NN cord-015021-pol2qm74 6316 18 of of IN cord-015021-pol2qm74 6316 19 mouse mouse NN cord-015021-pol2qm74 6316 20 . . . cord-015021-pol2qm74 6317 1 Co Co NNS cord-015021-pol2qm74 6317 2 - - NNS cord-015021-pol2qm74 6317 3 cultures culture NNS cord-015021-pol2qm74 6317 4 between between IN cord-015021-pol2qm74 6317 5 or or CC cord-015021-pol2qm74 6317 6 among among IN cord-015021-pol2qm74 6317 7 these these DT cord-015021-pol2qm74 6317 8 cells cell NNS cord-015021-pol2qm74 6317 9 with with IN cord-015021-pol2qm74 6317 10 Iipopolysaccharide Iipopolysaccharide NNP cord-015021-pol2qm74 6317 11 were be VBD cord-015021-pol2qm74 6317 12 performed perform VBN cord-015021-pol2qm74 6317 13 . . . cord-015021-pol2qm74 6318 1 Cytokine cytokine NN cord-015021-pol2qm74 6318 2 concentrations concentration NNS cord-015021-pol2qm74 6318 3 in in IN cord-015021-pol2qm74 6318 4 media medium NNS cord-015021-pol2qm74 6318 5 and and CC cord-015021-pol2qm74 6318 6 hepatocytic hepatocytic JJ cord-015021-pol2qm74 6318 7 function function NN cord-015021-pol2qm74 6318 8 were be VBD cord-015021-pol2qm74 6318 9 compared compare VBN cord-015021-pol2qm74 6318 10 . . . cord-015021-pol2qm74 6319 1 [ [ -LRB- cord-015021-pol2qm74 6319 2 Results result NNS cord-015021-pol2qm74 6319 3 and and CC cord-015021-pol2qm74 6319 4 Conclusion conclusion NN cord-015021-pol2qm74 6319 5 ] ] -RRB- cord-015021-pol2qm74 6319 6 Our -PRON- PRP$ cord-015021-pol2qm74 6319 7 findings finding NNS cord-015021-pol2qm74 6319 8 in in IN cord-015021-pol2qm74 6319 9 above above IN cord-015021-pol2qm74 6319 10 experiments experiment NNS cord-015021-pol2qm74 6319 11 demonstrated demonstrate VBD cord-015021-pol2qm74 6319 12 the the DT cord-015021-pol2qm74 6319 13 cleanly cleanly RB cord-015021-pol2qm74 6319 14 different different JJ cord-015021-pol2qm74 6319 15 concept concept NN cord-015021-pol2qm74 6319 16 for for IN cord-015021-pol2qm74 6319 17 the the DT cord-015021-pol2qm74 6319 18 mechanism mechanism NN cord-015021-pol2qm74 6319 19 of of IN cord-015021-pol2qm74 6319 20 hepatocyte hepatocyte NN cord-015021-pol2qm74 6319 21 dysfunction dysfunction NN cord-015021-pol2qm74 6319 22 following follow VBG cord-015021-pol2qm74 6319 23 sepsis sepsis NN cord-015021-pol2qm74 6319 24 or or CC cord-015021-pol2qm74 6319 25 major major JJ cord-015021-pol2qm74 6319 26 surgery surgery NN cord-015021-pol2qm74 6319 27 . . . cord-015021-pol2qm74 6320 1 Namely namely RB cord-015021-pol2qm74 6320 2 , , , cord-015021-pol2qm74 6320 3 the the DT cord-015021-pol2qm74 6320 4 effect effect NN cord-015021-pol2qm74 6320 5 of of IN cord-015021-pol2qm74 6320 6 hepatoeytie hepatoeytie NN cord-015021-pol2qm74 6320 7 function function NN cord-015021-pol2qm74 6320 8 by by IN cord-015021-pol2qm74 6320 9 cytokines cytokine NNS cord-015021-pol2qm74 6320 10 or or CC cord-015021-pol2qm74 6320 11 superioxide superioxide NN cord-015021-pol2qm74 6320 12 were be VBD cord-015021-pol2qm74 6320 13 significantly significantly RB cord-015021-pol2qm74 6320 14 affected affect VBN cord-015021-pol2qm74 6320 15 under under IN cord-015021-pol2qm74 6320 16 low low JJ cord-015021-pol2qm74 6320 17 oxygenation oxygenation NN cord-015021-pol2qm74 6320 18 , , , cord-015021-pol2qm74 6320 19 but but CC cord-015021-pol2qm74 6320 20 not not RB cord-015021-pol2qm74 6320 21 significant significant JJ cord-015021-pol2qm74 6320 22 under under IN cord-015021-pol2qm74 6320 23 good good JJ cord-015021-pol2qm74 6320 24 oxygenation oxygenation NN cord-015021-pol2qm74 6320 25 . . . cord-015021-pol2qm74 6321 1 Hirata Hirata NNP cord-015021-pol2qm74 6321 2 M.D.,Nishi M.D.,Nishi NNP cord-015021-pol2qm74 6322 1 17,Hokkaido 17,hokkaido CD cord-015021-pol2qm74 6322 2 , , , cord-015021-pol2qm74 6322 3 Japan Japan NNP cord-015021-pol2qm74 6322 4 $ $ $ cord-015021-pol2qm74 6322 5 120 120 CD cord-015021-pol2qm74 6322 6 470 470 CD cord-015021-pol2qm74 6322 7 immune immune JJ cord-015021-pol2qm74 6322 8 Complexes complex NNS cord-015021-pol2qm74 6322 9 as as IN cord-015021-pol2qm74 6322 10 .Mediators .mediator NNS cord-015021-pol2qm74 6322 11 of of IN cord-015021-pol2qm74 6322 12 Sepsis Sepsis NNP cord-015021-pol2qm74 6322 13 and and CC cord-015021-pol2qm74 6322 14 Immune Immune NNP cord-015021-pol2qm74 6322 15 Dyafumcffon Dyafumcffon NNP cord-015021-pol2qm74 6323 1 laa laa NNP cord-015021-pol2qm74 6323 2 K K NNP cord-015021-pol2qm74 6323 3 Horn Horn NNP cord-015021-pol2qm74 6323 4 , , , cord-015021-pol2qm74 6323 5 Chxistof Chxistof NNP cord-015021-pol2qm74 6323 6 Birkenmaier Birkenmaier NNP cord-015021-pol2qm74 6323 7 , , , cord-015021-pol2qm74 6323 8 and and CC cord-015021-pol2qm74 6323 9 Greg Greg NNP cord-015021-pol2qm74 6323 10 H2mon H2mon NNP cord-015021-pol2qm74 6323 11 Departmen~ departmen~ VBP cord-015021-pol2qm74 6323 12 of of IN cord-015021-pol2qm74 6323 13 Surgery surgery NN cord-015021-pol2qm74 6323 14 , , , cord-015021-pol2qm74 6323 15 San San NNP cord-015021-pol2qm74 6323 16 Frandsco Frandsco NNP cord-015021-pol2qm74 6323 17 General General NNP cord-015021-pol2qm74 6323 18 Hospital Hospital NNP cord-015021-pol2qm74 6323 19 , , , cord-015021-pol2qm74 6323 20 UrdversR urdversr JJ cord-015021-pol2qm74 6323 21 3 3 CD cord-015021-pol2qm74 6323 22 , , , cord-015021-pol2qm74 6323 23 of of IN cord-015021-pol2qm74 6323 24 Calif(~rrda Calif(~rrda NNP cord-015021-pol2qm74 6323 25 , , , cord-015021-pol2qm74 6323 26 San San NNP cord-015021-pol2qm74 6323 27 Frandsco Frandsco NNP cord-015021-pol2qm74 6323 28 . . . cord-015021-pol2qm74 6324 1 Immune immune JJ cord-015021-pol2qm74 6324 2 complexes complex NNS cord-015021-pol2qm74 6324 3 ( ( -LRB- cord-015021-pol2qm74 6325 1 IC IC NNP cord-015021-pol2qm74 6325 2 ) ) -RRB- cord-015021-pol2qm74 6325 3 a;:e a;:e NFP cord-015021-pol2qm74 6325 4 commonly commonly RB cord-015021-pol2qm74 6325 5 found find VBD cord-015021-pol2qm74 6325 6 circulating circulate VBG cord-015021-pol2qm74 6325 7 in in IN cord-015021-pol2qm74 6325 8 parians parian NNS cord-015021-pol2qm74 6325 9 during during IN cord-015021-pol2qm74 6325 10 infection infection NN cord-015021-pol2qm74 6325 11 and and CC cord-015021-pol2qm74 6325 12 sepsis sepsis NN cord-015021-pol2qm74 6325 13 ; ; : cord-015021-pol2qm74 6325 14 and and CC cord-015021-pol2qm74 6325 15 following follow VBG cord-015021-pol2qm74 6325 16 traumm traumm NNP cord-015021-pol2qm74 6325 17 , , , cord-015021-pol2qm74 6325 18 bums bum NNS cord-015021-pol2qm74 6325 19 , , , cord-015021-pol2qm74 6325 20 and and CC cord-015021-pol2qm74 6325 21 massive massive JJ cord-015021-pol2qm74 6325 22 l l NN cord-015021-pol2qm74 6325 23 ~ ~ CD cord-015021-pol2qm74 6325 24 ensfusion ensfusion NN cord-015021-pol2qm74 6325 25 . . . cord-015021-pol2qm74 6326 1 Clearance clearance NN cord-015021-pol2qm74 6326 2 of of IN cord-015021-pol2qm74 6326 3 1C 1c NN cord-015021-pol2qm74 6326 4 occurs occur VBZ cord-015021-pol2qm74 6326 5 by by IN cord-015021-pol2qm74 6326 6 phago~'Tmsis phago~'Tmsis NNP cord-015021-pol2qm74 6326 7 of of IN cord-015021-pol2qm74 6326 8 esll esll NNP cord-015021-pol2qm74 6326 9 - - HYPH cord-015021-pol2qm74 6326 10 bou_nd bou_nd NNP cord-015021-pol2qm74 6326 11 or or CC cord-015021-pol2qm74 6326 12 opsonized opsonize VBN cord-015021-pol2qm74 6326 13 p p NN cord-015021-pol2qm74 6326 14 ~ ~ CD cord-015021-pol2qm74 6326 15 tlcles tlcle NNS cord-015021-pol2qm74 6326 16 . . . cord-015021-pol2qm74 6327 1 Monocyte Monocyte NNP cord-015021-pol2qm74 6327 2 activation activation NN cord-015021-pol2qm74 6327 3 du du NNP cord-015021-pol2qm74 6328 1 ~Jng ~Jng NNP cord-015021-pol2qm74 6328 2 phmgocytos phmgocytos NNP cord-015021-pol2qm74 6328 3 / / SYM cord-015021-pol2qm74 6328 4 s s PRP cord-015021-pol2qm74 6328 5 could could MD cord-015021-pol2qm74 6328 6 lead lead VB cord-015021-pol2qm74 6328 7 ~o ~o NNP cord-015021-pol2qm74 6328 8 release release NN cord-015021-pol2qm74 6328 9 of of IN cord-015021-pol2qm74 6328 10 cytokilIes cytokilie NNS cord-015021-pol2qm74 6328 11 ieletexiot~ ieletexiot~ NNP cord-015021-pol2qm74 6328 12 to to IN cord-015021-pol2qm74 6328 13 the the DT cord-015021-pol2qm74 6328 14 hosh hosh NN cord-015021-pol2qm74 6329 1 To to TO cord-015021-pol2qm74 6329 2 examine examine VB cord-015021-pol2qm74 6329 3 tb tb NNP cord-015021-pol2qm74 6329 4 / / SYM cord-015021-pol2qm74 6329 5 s s POS cord-015021-pol2qm74 6329 6 phenomenon phenomenon NN cord-015021-pol2qm74 6329 7 , , , cord-015021-pol2qm74 6329 8 we -PRON- PRP cord-015021-pol2qm74 6329 9 formed form VBD cord-015021-pol2qm74 6329 10 insoluble insoluble JJ cord-015021-pol2qm74 6329 11 IC ic NN cord-015021-pol2qm74 6329 12 by by IN cord-015021-pol2qm74 6329 13 precipitating precipitate VBG cord-015021-pol2qm74 6329 14 Iow Iow NNP cord-015021-pol2qm74 6329 15 - - HYPH cord-015021-pol2qm74 6329 16 endotoxin endotoxin NN cord-015021-pol2qm74 6329 17 bovine bovine NN cord-015021-pol2qm74 6329 18 serun~ serun~ NN cord-015021-pol2qm74 6329 19 albumin albumin NN cord-015021-pol2qm74 6329 20 ( ( -LRB- cord-015021-pol2qm74 6329 21 BSA BSA NNP cord-015021-pol2qm74 6329 22 ) ) -RRB- cord-015021-pol2qm74 6329 23 with with IN cord-015021-pol2qm74 6329 24 rabbit rabbit NN cord-015021-pol2qm74 6329 25 ant/-BSA ant/-bsa NN cord-015021-pol2qm74 6330 1 IgG. IgG. NNP cord-015021-pol2qm74 6331 1 We -PRON- PRP cord-015021-pol2qm74 6331 2 have have VBP cord-015021-pol2qm74 6331 3 ~town ~town XX cord-015021-pol2qm74 6331 4 that that WDT cord-015021-pol2qm74 6331 5 these these DT cord-015021-pol2qm74 6331 6 IC IC NNP cord-015021-pol2qm74 6331 7 are be VBP cord-015021-pol2qm74 6331 8 ingested ingest VBN cord-015021-pol2qm74 6331 9 by by IN cord-015021-pol2qm74 6331 10 monocytes monocyte NNS cord-015021-pol2qm74 6331 11 and and CC cord-015021-pol2qm74 6331 12 concomitantly concomitantly RB cord-015021-pol2qm74 6331 13 stimv stimv NNP cord-015021-pol2qm74 6331 14 / / SYM cord-015021-pol2qm74 6331 15 ate eat VBD cord-015021-pol2qm74 6331 16 re re NNP cord-015021-pol2qm74 6331 17 ~ ~ CD cord-015021-pol2qm74 6331 18 pizatory pizatory NNP cord-015021-pol2qm74 6331 19 bu bu NNP cord-015021-pol2qm74 6331 20 ~ ~ NNP cord-015021-pol2qm74 6331 21 t t XX cord-015021-pol2qm74 6331 22 activity activity NN cord-015021-pol2qm74 6331 23 measuxed measuxed NNP cord-015021-pol2qm74 6331 24 by by IN cord-015021-pol2qm74 6331 25 assay assay NN cord-015021-pol2qm74 6331 26 of of IN cord-015021-pol2qm74 6331 27 in%racellul~ in%racellul~ NNP cord-015021-pol2qm74 6331 28 peroxldaffon peroxldaffon JJ cord-015021-pol2qm74 6331 29 . . . cord-015021-pol2qm74 6332 1 We -PRON- PRP cord-015021-pol2qm74 6332 2 have have VBP cord-015021-pol2qm74 6332 3 shown show VBN cord-015021-pol2qm74 6332 4 that that IN cord-015021-pol2qm74 6332 5 IC IC NNP cord-015021-pol2qm74 6332 6 ingesffon ingesffon NNP cord-015021-pol2qm74 6332 7 produces produce VBZ cord-015021-pol2qm74 6332 8 signLqcant signlqcant JJ cord-015021-pol2qm74 6332 9 el el NNP cord-015021-pol2qm74 6332 10 , , , cord-015021-pol2qm74 6332 11 era era NN cord-015021-pol2qm74 6332 12 , , , cord-015021-pol2qm74 6332 13 lore lore NN cord-015021-pol2qm74 6332 14 in in IN cord-015021-pol2qm74 6332 15 the the DT cord-015021-pol2qm74 6332 16 monoey monoey NN cord-015021-pol2qm74 6332 17 ~ ~ NFP cord-015021-pol2qm74 6332 18 e e NN cord-015021-pol2qm74 6332 19 phenotype phenotype NN cord-015021-pol2qm74 6332 20 . . . cord-015021-pol2qm74 6333 1 Spedacally Spedacally NNP cord-015021-pol2qm74 6333 2 , , , cord-015021-pol2qm74 6333 3 CDI4 CDI4 NNP cord-015021-pol2qm74 6333 4 is be VBZ cord-015021-pol2qm74 6333 5 down down RB cord-015021-pol2qm74 6333 6 - - HYPH cord-015021-pol2qm74 6333 7 regu regu NN cord-015021-pol2qm74 6333 8 / / SYM cord-015021-pol2qm74 6333 9 ated ate VBN cord-015021-pol2qm74 6333 10 , , , cord-015021-pol2qm74 6333 11 along along IN cord-015021-pol2qm74 6333 12 wl~ wl~ NN cord-015021-pol2qm74 6333 13 CD CD NNP cord-015021-pol2qm74 6333 14 32 32 CD cord-015021-pol2qm74 6333 15 and and CC cord-015021-pol2qm74 6333 16 CD64 CD64 NNP cord-015021-pol2qm74 6333 17 . . . cord-015021-pol2qm74 6334 1 Thus thus RB cord-015021-pol2qm74 6334 2 responsiveness responsiveness NN cord-015021-pol2qm74 6334 3 to to IN cord-015021-pol2qm74 6334 4 lipopolysacchmdde lipopolysacchmdde NNP cord-015021-pol2qm74 6334 5 ( ( -LRB- cord-015021-pol2qm74 6334 6 128 128 CD cord-015021-pol2qm74 6334 7 ) ) -RRB- cord-015021-pol2qm74 6334 8 a a DT cord-015021-pol2qm74 6335 1 ~xd ~xd NNP cord-015021-pol2qm74 6335 2 i i PRP cord-015021-pol2qm74 6335 3 = = SYM cord-015021-pol2qm74 6335 4 m m NNP cord-015021-pol2qm74 6335 5 ~ ~ NFP cord-015021-pol2qm74 6335 6 unoglobulin unoglobulin NNP cord-015021-pol2qm74 6335 7 Fe Fe NNP cord-015021-pol2qm74 6335 8 st st NNP cord-015021-pol2qm74 6335 9 ~ ~ NNP cord-015021-pol2qm74 6335 10 mu mu NNP cord-015021-pol2qm74 6335 11 / / SYM cord-015021-pol2qm74 6335 12 mtlon mtlon NNP cord-015021-pol2qm74 6335 13 is be VBZ cord-015021-pol2qm74 6335 14 reduced reduce VBN cord-015021-pol2qm74 6335 15 . . . cord-015021-pol2qm74 6336 1 In in IN cord-015021-pol2qm74 6336 2 cert,+rest cert,+r JJS cord-015021-pol2qm74 6336 3 , , , cord-015021-pol2qm74 6336 4 the the DT cord-015021-pol2qm74 6336 5 complement complement NN cord-015021-pol2qm74 6336 6 rote.p rote.p TO cord-015021-pol2qm74 6336 7 tot tot NNP cord-015021-pol2qm74 6336 8 CDC42 CDC42 NNP cord-015021-pol2qm74 6336 9 is be VBZ cord-015021-pol2qm74 6336 10 u~-regulamd u~-regulamd JJR cord-015021-pol2qm74 6336 11 , , , cord-015021-pol2qm74 6336 12 indicaling indicale VBG cord-015021-pol2qm74 6336 13 Mcremsed Mcremsed NNP cord-015021-pol2qm74 6336 14 re re NNP cord-015021-pol2qm74 6336 15 ~ ~ CD cord-015021-pol2qm74 6336 16 ponalx=~ness ponalx=~ness NNP cord-015021-pol2qm74 6336 17 to to IN cord-015021-pol2qm74 6336 18 opsonized opsonized NNP cord-015021-pol2qm74 6336 19 pat pat NNP cord-015021-pol2qm74 6336 20 , , , cord-015021-pol2qm74 6336 21 rotes rotes NNP cord-015021-pol2qm74 6336 22 , , , cord-015021-pol2qm74 6336 23 we -PRON- PRP cord-015021-pol2qm74 6336 24 examined examine VBD cord-015021-pol2qm74 6336 25 monocyte monocyte NNP cord-015021-pol2qm74 6336 26 superna~ superna~ NNS cord-015021-pol2qm74 6337 1 n n NNP cord-015021-pol2qm74 6337 2 ~ ~ NNP cord-015021-pol2qm74 6337 3 s s NNP cord-015021-pol2qm74 6337 4 for for IN cord-015021-pol2qm74 6337 5 production production NN cord-015021-pol2qm74 6337 6 of of IN cord-015021-pol2qm74 6337 7 hzmor hzmor NNP cord-015021-pol2qm74 6337 8 necrosis necrosis NN cord-015021-pol2qm74 6337 9 factor factor NN cord-015021-pol2qm74 6337 10 alpha alpha NNP cord-015021-pol2qm74 6337 11 ( ( -LRB- cord-015021-pol2qm74 6337 12 TNFg TNFg NNP cord-015021-pol2qm74 6337 13 ) ) -RRB- cord-015021-pol2qm74 6338 1 following follow VBG cord-015021-pol2qm74 6338 2 IC IC NNP cord-015021-pol2qm74 6338 3 stimulation stimulation NN cord-015021-pol2qm74 6338 4 and and CC cord-015021-pol2qm74 6338 5 showed show VBD cord-015021-pol2qm74 6338 6 that that IN cord-015021-pol2qm74 6338 7 IC IC NNP cord-015021-pol2qm74 6338 8 are be VBP cord-015021-pol2qm74 6338 9 capable capable JJ cord-015021-pol2qm74 6338 10 of of IN cord-015021-pol2qm74 6338 11 provoking provoke VBG cord-015021-pol2qm74 6338 12 ~elaase ~elaase CD cord-015021-pol2qm74 6338 13 of of IN cord-015021-pol2qm74 6338 14 hrmaunl)reac hrmaunl)reac NNP cord-015021-pol2qm74 6339 1 ~ve ~ve NNP cord-015021-pol2qm74 6339 2 TNI~. TNI~. NNP cord-015021-pol2qm74 6339 3 J[C j[c NN cord-015021-pol2qm74 6339 4 also also RB cord-015021-pol2qm74 6339 5 increase increase VBP cord-015021-pol2qm74 6339 6 mono mono NN cord-015021-pol2qm74 6339 7 = = SYM cord-015021-pol2qm74 6339 8 yte yte NNP cord-015021-pol2qm74 6339 9 producHon producHon NNP cord-015021-pol2qm74 6339 10 of of IN cord-015021-pol2qm74 6339 11 prnstaglandin prnstaglandin NNP cord-015021-pol2qm74 6339 12 E2 E2 NNP cord-015021-pol2qm74 6339 13 . . . cord-015021-pol2qm74 6340 1 in in IN cord-015021-pol2qm74 6340 2 summary summary NN cord-015021-pol2qm74 6340 3 , , , cord-015021-pol2qm74 6340 4 ~/~ese ~/~ese NN cord-015021-pol2qm74 6340 5 results result NNS cord-015021-pol2qm74 6340 6 demonstrate demonstrate VBP cord-015021-pol2qm74 6340 7 Lhmt Lhmt NNP cord-015021-pol2qm74 6340 8 IC IC NNP cord-015021-pol2qm74 6340 9 are be VBP cord-015021-pol2qm74 6340 10 capable capable JJ cord-015021-pol2qm74 6340 11 of of IN cord-015021-pol2qm74 6340 12 indudng indudng NN cord-015021-pol2qm74 6340 13 production production NN cord-015021-pol2qm74 6340 14 of of IN cord-015021-pol2qm74 6340 15 ¢ytokines ¢ytokines NNP cord-015021-pol2qm74 6340 16 and and CC cord-015021-pol2qm74 6340 17 the the DT cord-015021-pol2qm74 6340 18 imrau imrau NNP cord-015021-pol2qm74 6340 19 - - HYPH cord-015021-pol2qm74 6340 20 nosuppressive nosuppressive NNP cord-015021-pol2qm74 6340 21 prostaglandin prostaglandin NN cord-015021-pol2qm74 6340 22 PGE2 PGE2 NNP cord-015021-pol2qm74 6340 23 . . . cord-015021-pol2qm74 6341 1 IC IC NNP cord-015021-pol2qm74 6341 2 also also RB cord-015021-pol2qm74 6341 3 allez allez NNP cord-015021-pol2qm74 6341 4 ~he ~he NNP cord-015021-pol2qm74 6341 5 surface surface VBP cord-015021-pol2qm74 6341 6 expression expression NN cord-015021-pol2qm74 6341 7 of of IN cord-015021-pol2qm74 6341 8 important important JJ cord-015021-pol2qm74 6341 9 receptors receptor NNS cord-015021-pol2qm74 6341 10 involved involve VBN cord-015021-pol2qm74 6341 11 in in IN cord-015021-pol2qm74 6341 12 actlvaffon actlvaffon NN cord-015021-pol2qm74 6341 13 by by IN cord-015021-pol2qm74 6341 14 LP~ LP~ NNP cord-015021-pol2qm74 6341 15 and and CC cord-015021-pol2qm74 6341 16 phagocyIosis phagocyiosis NN cord-015021-pol2qm74 6341 17 . . . cord-015021-pol2qm74 6342 1 Thus thus RB cord-015021-pol2qm74 6342 2 , , , cord-015021-pol2qm74 6342 3 IC IC NNP cord-015021-pol2qm74 6342 4 aze aze NNP cord-015021-pol2qm74 6342 5 competent competent JJ cord-015021-pol2qm74 6342 6 for for IN cord-015021-pol2qm74 6342 7 indud indud NNP cord-015021-pol2qm74 6342 8 / / , cord-015021-pol2qm74 6342 9 on on IN cord-015021-pol2qm74 6342 10 of of IN cord-015021-pol2qm74 6342 11 the the DT cord-015021-pol2qm74 6342 12 mepl mepl NNP cord-015021-pol2qm74 6342 13 / / SYM cord-015021-pol2qm74 6342 14 e e NNP cord-015021-pol2qm74 6342 15 s!0otLse s!0otLse NNP cord-015021-pol2qm74 6342 16 . . . cord-015021-pol2qm74 6343 1 By by IN cord-015021-pol2qm74 6343 2 examining examine VBG cord-015021-pol2qm74 6343 3 m0n0cyte m0n0cyte CD cord-015021-pol2qm74 6343 4 phenotypms phenotypms NNP cord-015021-pol2qm74 6343 5 , , , cord-015021-pol2qm74 6343 6 it -PRON- PRP cord-015021-pol2qm74 6343 7 may may MD cord-015021-pol2qm74 6343 8 be be VB cord-015021-pol2qm74 6343 9 possible possible JJ cord-015021-pol2qm74 6343 10 tO to IN cord-015021-pol2qm74 6343 11 d d XX cord-015021-pol2qm74 6344 1 ~mrmkne ~mrmkne NNP cord-015021-pol2qm74 6344 2 extent extent NN cord-015021-pol2qm74 6344 3 oHn'u~ oHn'u~ NNP cord-015021-pol2qm74 6345 1 u u NNP cord-015021-pol2qm74 6345 2 ~ ~ NNP cord-015021-pol2qm74 6345 3 e e LS cord-015021-pol2qm74 6345 4 complex complex JJ cord-015021-pol2qm74 6345 5 activation activation NN cord-015021-pol2qm74 6345 6 and and CC cord-015021-pol2qm74 6345 7 predict predict VB cord-015021-pol2qm74 6345 8 immune immune JJ cord-015021-pol2qm74 6345 9 depression depression NN cord-015021-pol2qm74 6345 10 iu iu IN cord-015021-pol2qm74 6345 11 criffcally criffcally RB cord-015021-pol2qm74 6345 12 ill ill NNP cord-015021-pol2qm74 6345 13 pa pa NNP cord-015021-pol2qm74 6345 14 ~ ~ CD cord-015021-pol2qm74 6345 15 ents ent NNS cord-015021-pol2qm74 6345 16 . . . cord-015021-pol2qm74 6346 1 A a DT cord-015021-pol2qm74 6346 2 great great JJ cord-015021-pol2qm74 6346 3 deal deal NN cord-015021-pol2qm74 6346 4 of of IN cord-015021-pol2qm74 6346 5 experimental experimental JJ cord-015021-pol2qm74 6346 6 work work NN cord-015021-pol2qm74 6346 7 has have VBZ cord-015021-pol2qm74 6346 8 focused focus VBN cord-015021-pol2qm74 6346 9 on on IN cord-015021-pol2qm74 6346 10 preventing prevent VBG cord-015021-pol2qm74 6346 11 and/or and/or CC cord-015021-pol2qm74 6346 12 treating treat VBG cord-015021-pol2qm74 6346 13 sepsis sepsis NN cord-015021-pol2qm74 6346 14 and and CC cord-015021-pol2qm74 6346 15 organ organ NN cord-015021-pol2qm74 6346 16 failure failure NN cord-015021-pol2qm74 6346 17 following follow VBG cord-015021-pol2qm74 6346 18 injury injury NN cord-015021-pol2qm74 6346 19 . . . cord-015021-pol2qm74 6347 1 Many many JJ cord-015021-pol2qm74 6347 2 of of IN cord-015021-pol2qm74 6347 3 these these DT cord-015021-pol2qm74 6347 4 strategies strategy NNS cord-015021-pol2qm74 6347 5 have have VBP cord-015021-pol2qm74 6347 6 tried try VBN cord-015021-pol2qm74 6347 7 to to TO cord-015021-pol2qm74 6347 8 attack attack VB cord-015021-pol2qm74 6347 9 mediator mediator NN cord-015021-pol2qm74 6347 10 substances substance NNS cord-015021-pol2qm74 6347 11 released release VBN cord-015021-pol2qm74 6347 12 during during IN cord-015021-pol2qm74 6347 13 the the DT cord-015021-pol2qm74 6347 14 systemic systemic JJ cord-015021-pol2qm74 6347 15 inflammatory inflammatory JJ cord-015021-pol2qm74 6347 16 response response NN cord-015021-pol2qm74 6347 17 following follow VBG cord-015021-pol2qm74 6347 18 injury injury NN cord-015021-pol2qm74 6347 19 . . . cord-015021-pol2qm74 6348 1 Sugermann Sugermann NNP cord-015021-pol2qm74 6348 2 has have VBZ cord-015021-pol2qm74 6348 3 demonstrated demonstrate VBN cord-015021-pol2qm74 6348 4 the the DT cord-015021-pol2qm74 6348 5 improvement improvement NN cord-015021-pol2qm74 6348 6 of of IN cord-015021-pol2qm74 6348 7 pulmonary pulmonary JJ cord-015021-pol2qm74 6348 8 function function NN cord-015021-pol2qm74 6348 9 , , , cord-015021-pol2qm74 6348 10 but but CC cord-015021-pol2qm74 6348 11 not not RB cord-015021-pol2qm74 6348 12 eappillary eappillary NNP cord-015021-pol2qm74 6348 13 leak leak NN cord-015021-pol2qm74 6348 14 using use VBG cord-015021-pol2qm74 6348 15 [ [ -LRB- cord-015021-pol2qm74 6348 16 buprofen buprofen NN cord-015021-pol2qm74 6348 17 in in IN cord-015021-pol2qm74 6348 18 the the DT cord-015021-pol2qm74 6348 19 porcine porcine JJ cord-015021-pol2qm74 6348 20 model model NN cord-015021-pol2qm74 6348 21 . . . cord-015021-pol2qm74 6349 1 In in IN cord-015021-pol2qm74 6349 2 a a DT cord-015021-pol2qm74 6349 3 clinical clinical JJ cord-015021-pol2qm74 6349 4 trial trial NN cord-015021-pol2qm74 6349 5 , , , cord-015021-pol2qm74 6349 6 Faist Faist NNP cord-015021-pol2qm74 6349 7 demonstrated demonstrate VBD cord-015021-pol2qm74 6349 8 the the DT cord-015021-pol2qm74 6349 9 effectiveness effectiveness NN cord-015021-pol2qm74 6349 10 of of IN cord-015021-pol2qm74 6349 11 Indomethacine Indomethacine NNP cord-015021-pol2qm74 6349 12 in in IN cord-015021-pol2qm74 6349 13 amelierating amelierate VBG cord-015021-pol2qm74 6349 14 the the DT cord-015021-pol2qm74 6349 15 post post NN cord-015021-pol2qm74 6349 16 trauma trauma NN cord-015021-pol2qm74 6349 17 of of IN cord-015021-pol2qm74 6349 18 cellular cellular JJ cord-015021-pol2qm74 6349 19 amenity amenity NN cord-015021-pol2qm74 6349 20 using use VBG cord-015021-pol2qm74 6349 21 in in IN cord-015021-pol2qm74 6349 22 vitro vitro FW cord-015021-pol2qm74 6349 23 parameters parameter NNS cord-015021-pol2qm74 6349 24 . . . cord-015021-pol2qm74 6350 1 Morbidity morbidity NN cord-015021-pol2qm74 6350 2 and and CC cord-015021-pol2qm74 6350 3 mortality mortality NN cord-015021-pol2qm74 6350 4 , , , cord-015021-pol2qm74 6350 5 however however RB cord-015021-pol2qm74 6350 6 , , , cord-015021-pol2qm74 6350 7 were be VBD cord-015021-pol2qm74 6350 8 not not RB cord-015021-pol2qm74 6350 9 different different JJ cord-015021-pol2qm74 6350 10 between between IN cord-015021-pol2qm74 6350 11 control control NN cord-015021-pol2qm74 6350 12 and and CC cord-015021-pol2qm74 6350 13 treatment treatment NN cord-015021-pol2qm74 6350 14 groups group NNS cord-015021-pol2qm74 6350 15 . . . cord-015021-pol2qm74 6351 1 Baue Baue NNP cord-015021-pol2qm74 6351 2 und und IN cord-015021-pol2qm74 6351 3 Chaudry Chaudry NNP cord-015021-pol2qm74 6351 4 have have VBP cord-015021-pol2qm74 6351 5 suggested suggest VBN cord-015021-pol2qm74 6351 6 that that IN cord-015021-pol2qm74 6351 7 ATP ATP NNP cord-015021-pol2qm74 6351 8 magnesium magnesium NN cord-015021-pol2qm74 6351 9 chloride chloride NN cord-015021-pol2qm74 6351 10 may may MD cord-015021-pol2qm74 6351 11 have have VB cord-015021-pol2qm74 6351 12 protective protective JJ cord-015021-pol2qm74 6351 13 effect effect NN cord-015021-pol2qm74 6351 14 in in IN cord-015021-pol2qm74 6351 15 renal renal JJ cord-015021-pol2qm74 6351 16 failure failure NN cord-015021-pol2qm74 6351 17 uM um UH cord-015021-pol2qm74 6351 18 Kupfer Kupfer NNP cord-015021-pol2qm74 6351 19 cell cell NN cord-015021-pol2qm74 6351 20 dysfunction dysfunction NN cord-015021-pol2qm74 6351 21 seen see VBN cord-015021-pol2qm74 6351 22 after after IN cord-015021-pol2qm74 6351 23 shock shock NN cord-015021-pol2qm74 6351 24 . . . cord-015021-pol2qm74 6352 1 Pentoxiphyllin Pentoxiphyllin NNP cord-015021-pol2qm74 6352 2 has have VBZ cord-015021-pol2qm74 6352 3 been be VBN cord-015021-pol2qm74 6352 4 found find VBN cord-015021-pol2qm74 6352 5 to to TO cord-015021-pol2qm74 6352 6 be be VB cord-015021-pol2qm74 6352 7 effective effective JJ cord-015021-pol2qm74 6352 8 in in IN cord-015021-pol2qm74 6352 9 improving improve VBG cord-015021-pol2qm74 6352 10 tissue tissue NN cord-015021-pol2qm74 6352 11 oxygenation oxygenation NN cord-015021-pol2qm74 6352 12 and and CC cord-015021-pol2qm74 6352 13 oxygen oxygen NN cord-015021-pol2qm74 6352 14 consumption consumption NN cord-015021-pol2qm74 6352 15 following follow VBG cord-015021-pol2qm74 6352 16 hemorrhage hemorrhage NN cord-015021-pol2qm74 6352 17 , , , cord-015021-pol2qm74 6352 18 and and CC cord-015021-pol2qm74 6352 19 there there EX cord-015021-pol2qm74 6352 20 may may MD cord-015021-pol2qm74 6352 21 be be VB cord-015021-pol2qm74 6352 22 promise promise NN cord-015021-pol2qm74 6352 23 for for IN cord-015021-pol2qm74 6352 24 this this DT cord-015021-pol2qm74 6352 25 drug drug NN cord-015021-pol2qm74 6352 26 in in IN cord-015021-pol2qm74 6352 27 the the DT cord-015021-pol2qm74 6352 28 ischemia ischemia NN cord-015021-pol2qm74 6352 29 reperfusion reperfusion NN cord-015021-pol2qm74 6352 30 injury injury NN cord-015021-pol2qm74 6352 31 . . . cord-015021-pol2qm74 6353 1 Monoclonal monoclonal JJ cord-015021-pol2qm74 6353 2 antibodies antibody NNS cord-015021-pol2qm74 6353 3 against against IN cord-015021-pol2qm74 6353 4 endothxin endothxin NN cord-015021-pol2qm74 6353 5 and and CC cord-015021-pol2qm74 6353 6 inflammatory inflammatory JJ cord-015021-pol2qm74 6353 7 mediators mediator NNS cord-015021-pol2qm74 6353 8 seemed seem VBD cord-015021-pol2qm74 6353 9 promising promise VBG cord-015021-pol2qm74 6353 10 at at IN cord-015021-pol2qm74 6353 11 first first JJ cord-015021-pol2qm74 6353 12 glance glance NN cord-015021-pol2qm74 6353 13 ; ; : cord-015021-pol2qm74 6353 14 however however RB cord-015021-pol2qm74 6353 15 , , , cord-015021-pol2qm74 6353 16 preliminiary preliminiary DT cord-015021-pol2qm74 6353 17 clinical clinical JJ cord-015021-pol2qm74 6353 18 data datum NNS cord-015021-pol2qm74 6353 19 of of IN cord-015021-pol2qm74 6353 20 the the DT cord-015021-pol2qm74 6353 21 treatment treatment NN cord-015021-pol2qm74 6353 22 of of IN cord-015021-pol2qm74 6353 23 sepsis sepsis NN cord-015021-pol2qm74 6353 24 with with IN cord-015021-pol2qm74 6353 25 either either CC cord-015021-pol2qm74 6353 26 HA HA NNP cord-015021-pol2qm74 6353 27 - - HYPH cord-015021-pol2qm74 6353 28 IA IA NNP cord-015021-pol2qm74 6353 29 or or CC cord-015021-pol2qm74 6353 30 E5 E5 NNP cord-015021-pol2qm74 6353 31 monoelonoal monoelonoal JJ cord-015021-pol2qm74 6353 32 antibodies antibody NNS cord-015021-pol2qm74 6353 33 against against IN cord-015021-pol2qm74 6353 34 bacterial bacterial JJ cord-015021-pol2qm74 6353 35 cell cell NN cord-015021-pol2qm74 6353 36 wall wall NN cord-015021-pol2qm74 6353 37 have have VBP cord-015021-pol2qm74 6353 38 been be VBN cord-015021-pol2qm74 6353 39 disappointing disappointing JJ cord-015021-pol2qm74 6353 40 . . . cord-015021-pol2qm74 6354 1 Initial initial JJ cord-015021-pol2qm74 6354 2 studies study NNS cord-015021-pol2qm74 6354 3 with with IN cord-015021-pol2qm74 6354 4 IL IL NNP cord-015021-pol2qm74 6354 5 - - : cord-015021-pol2qm74 6354 6 I I NNP cord-015021-pol2qm74 6354 7 receptor receptor NN cord-015021-pol2qm74 6354 8 antagonist antagonist NN cord-015021-pol2qm74 6354 9 also also RB cord-015021-pol2qm74 6354 10 appeared appear VBD cord-015021-pol2qm74 6354 11 encouraging encouraging JJ cord-015021-pol2qm74 6354 12 , , , cord-015021-pol2qm74 6354 13 but but CC cord-015021-pol2qm74 6354 14 no no DT cord-015021-pol2qm74 6354 15 difference difference NN cord-015021-pol2qm74 6354 16 was be VBD cord-015021-pol2qm74 6354 17 seen see VBN cord-015021-pol2qm74 6354 18 in in IN cord-015021-pol2qm74 6354 19 the the DT cord-015021-pol2qm74 6354 20 most most RBS cord-015021-pol2qm74 6354 21 recent recent JJ cord-015021-pol2qm74 6354 22 trial trial NN cord-015021-pol2qm74 6354 23 . . . cord-015021-pol2qm74 6355 1 Currently currently RB cord-015021-pol2qm74 6355 2 studies study NNS cord-015021-pol2qm74 6355 3 are be VBP cord-015021-pol2qm74 6355 4 ongoing ongoing JJ cord-015021-pol2qm74 6355 5 with with IN cord-015021-pol2qm74 6355 6 monoclonal monoclonal JJ cord-015021-pol2qm74 6355 7 antibodies antibody NNS cord-015021-pol2qm74 6355 8 to to TO cord-015021-pol2qm74 6355 9 tumor tumor NN cord-015021-pol2qm74 6355 10 necrosis necrosis NN cord-015021-pol2qm74 6355 11 factor factor NN cord-015021-pol2qm74 6355 12 which which WDT cord-015021-pol2qm74 6355 13 may may MD cord-015021-pol2qm74 6355 14 have have VB cord-015021-pol2qm74 6355 15 more more JJR cord-015021-pol2qm74 6355 16 efficacy efficacy NN cord-015021-pol2qm74 6355 17 given give VBN cord-015021-pol2qm74 6355 18 the the DT cord-015021-pol2qm74 6355 19 fact fact NN cord-015021-pol2qm74 6355 20 that that IN cord-015021-pol2qm74 6355 21 it -PRON- PRP cord-015021-pol2qm74 6355 22 is be VBZ cord-015021-pol2qm74 6355 23 a a DT cord-015021-pol2qm74 6355 24 macrophage macrophage NN cord-015021-pol2qm74 6355 25 mediator mediator NN cord-015021-pol2qm74 6355 26 released release VBN cord-015021-pol2qm74 6355 27 by by IN cord-015021-pol2qm74 6355 28 endotoxin endotoxin NN cord-015021-pol2qm74 6355 29 . . . cord-015021-pol2qm74 6356 1 Although although IN cord-015021-pol2qm74 6356 2 we -PRON- PRP cord-015021-pol2qm74 6356 3 seem seem VBP cord-015021-pol2qm74 6356 4 closer close RBR cord-015021-pol2qm74 6356 5 to to IN cord-015021-pol2qm74 6356 6 understanding understanding NN cord-015021-pol2qm74 6356 7 and and CC cord-015021-pol2qm74 6356 8 preventing prevent VBG cord-015021-pol2qm74 6356 9 the the DT cord-015021-pol2qm74 6356 10 problems problem NNS cord-015021-pol2qm74 6356 11 of of IN cord-015021-pol2qm74 6356 12 sepsis sepsis NN cord-015021-pol2qm74 6356 13 and and CC cord-015021-pol2qm74 6356 14 organg organg NNP cord-015021-pol2qm74 6356 15 failure failure NN cord-015021-pol2qm74 6356 16 after after IN cord-015021-pol2qm74 6356 17 trauma trauma NN cord-015021-pol2qm74 6356 18 , , , cord-015021-pol2qm74 6356 19 we -PRON- PRP cord-015021-pol2qm74 6356 20 must must MD cord-015021-pol2qm74 6356 21 continue continue VB cord-015021-pol2qm74 6356 22 to to TO cord-015021-pol2qm74 6356 23 appreciate appreciate VB cord-015021-pol2qm74 6356 24 the the DT cord-015021-pol2qm74 6356 25 complex complex JJ cord-015021-pol2qm74 6356 26 interrelationships interrelationship NNS cord-015021-pol2qm74 6356 27 and and CC cord-015021-pol2qm74 6356 28 delicate delicate JJ cord-015021-pol2qm74 6356 29 balances balance NNS cord-015021-pol2qm74 6356 30 inherent inherent JJ cord-015021-pol2qm74 6356 31 in in IN cord-015021-pol2qm74 6356 32 the the DT cord-015021-pol2qm74 6356 33 host host NN cord-015021-pol2qm74 6356 34 defense defense NN cord-015021-pol2qm74 6356 35 system system NN cord-015021-pol2qm74 6356 36 . . . cord-015021-pol2qm74 6357 1 Overzealous overzealous JJ cord-015021-pol2qm74 6357 2 attempts attempt NNS cord-015021-pol2qm74 6357 3 at at IN cord-015021-pol2qm74 6357 4 restoring restore VBG cord-015021-pol2qm74 6357 5 immunity immunity NN cord-015021-pol2qm74 6357 6 in in IN cord-015021-pol2qm74 6357 7 the the DT cord-015021-pol2qm74 6357 8 absence absence NN cord-015021-pol2qm74 6357 9 of of IN cord-015021-pol2qm74 6357 10 understanding understand VBG cord-015021-pol2qm74 6357 11 pathophysiology pathophysiology NN cord-015021-pol2qm74 6357 12 may may MD cord-015021-pol2qm74 6357 13 be be VB cord-015021-pol2qm74 6357 14 just just RB cord-015021-pol2qm74 6357 15 as as RB cord-015021-pol2qm74 6357 16 dangerous dangerous JJ cord-015021-pol2qm74 6357 17 at at IN cord-015021-pol2qm74 6357 18 post post JJ cord-015021-pol2qm74 6357 19 - - JJ cord-015021-pol2qm74 6357 20 traumatic traumatic JJ cord-015021-pol2qm74 6357 21 immlmospremsion immlmospremsion NN cord-015021-pol2qm74 6357 22 . . . cord-015021-pol2qm74 6358 1 Severe severe JJ cord-015021-pol2qm74 6358 2 acute acute JJ cord-015021-pol2qm74 6358 3 pancreatitis pancreatitis NN cord-015021-pol2qm74 6358 4 was be VBD cord-015021-pol2qm74 6358 5 caused cause VBN cord-015021-pol2qm74 6358 6 by by IN cord-015021-pol2qm74 6358 7 different different JJ cord-015021-pol2qm74 6358 8 etiologic etiologic JJ cord-015021-pol2qm74 6358 9 factors factor NNS cord-015021-pol2qm74 6358 10 , , , cord-015021-pol2qm74 6358 11 but but CC cord-015021-pol2qm74 6358 12 once once IN cord-015021-pol2qm74 6358 13 pancreatic pancreatic JJ cord-015021-pol2qm74 6358 14 tissues tissue NNS cord-015021-pol2qm74 6358 15 were be VBD cord-015021-pol2qm74 6358 16 infected infect VBN cord-015021-pol2qm74 6358 17 , , , cord-015021-pol2qm74 6358 18 patients patient NNS cord-015021-pol2qm74 6358 19 show show VBP cord-015021-pol2qm74 6358 20 a a DT cord-015021-pol2qm74 6358 21 similar similar JJ cord-015021-pol2qm74 6358 22 pattern pattern NN cord-015021-pol2qm74 6358 23 of of IN cord-015021-pol2qm74 6358 24 aggravation aggravation NN cord-015021-pol2qm74 6358 25 and and CC cord-015021-pol2qm74 6358 26 develop develop VB cord-015021-pol2qm74 6358 27 organ organ NN cord-015021-pol2qm74 6358 28 failure failure NN cord-015021-pol2qm74 6358 29 . . . cord-015021-pol2qm74 6359 1 Remarkable remarkable JJ cord-015021-pol2qm74 6359 2 elevation elevation NN cord-015021-pol2qm74 6359 3 of of IN cord-015021-pol2qm74 6359 4 serum serum NN cord-015021-pol2qm74 6359 5 IL-6 IL-6 NNP cord-015021-pol2qm74 6359 6 was be VBD cord-015021-pol2qm74 6359 7 unexceptionally unexceptionally RB cord-015021-pol2qm74 6359 8 observed observe VBN cord-015021-pol2qm74 6359 9 in in IN cord-015021-pol2qm74 6359 10 patients patient NNS cord-015021-pol2qm74 6359 11 with with IN cord-015021-pol2qm74 6359 12 severe severe JJ cord-015021-pol2qm74 6359 13 acute acute JJ cord-015021-pol2qm74 6359 14 pancreatitis pancreatitis NN cord-015021-pol2qm74 6359 15 . . . cord-015021-pol2qm74 6360 1 The the DT cord-015021-pol2qm74 6360 2 serum serum NN cord-015021-pol2qm74 6360 3 levels level NNS cord-015021-pol2qm74 6360 4 were be VBD cord-015021-pol2qm74 6360 5 more more JJR cord-015021-pol2qm74 6360 6 than than IN cord-015021-pol2qm74 6360 7 500 500 CD cord-015021-pol2qm74 6360 8 pg pg NN cord-015021-pol2qm74 6360 9 / / SYM cord-015021-pol2qm74 6360 10 ml ml IN cord-015021-pol2qm74 6360 11 ( ( -LRB- cord-015021-pol2qm74 6360 12 normal normal JJ cord-015021-pol2qm74 6360 13 : : : cord-015021-pol2qm74 6360 14 less less JJR cord-015021-pol2qm74 6360 15 than than IN cord-015021-pol2qm74 6360 16 4 4 CD cord-015021-pol2qm74 6360 17 pg pg NN cord-015021-pol2qm74 6360 18 / / SYM cord-015021-pol2qm74 6360 19 ml ml NNP cord-015021-pol2qm74 6360 20 ) ) -RRB- cord-015021-pol2qm74 6360 21 during during IN cord-015021-pol2qm74 6360 22 the the DT cord-015021-pol2qm74 6360 23 first first JJ cord-015021-pol2qm74 6360 24 one one CD cord-015021-pol2qm74 6360 25 or or CC cord-015021-pol2qm74 6360 26 two two CD cord-015021-pol2qm74 6360 27 days day NNS cord-015021-pol2qm74 6360 28 after after IN cord-015021-pol2qm74 6360 29 onset onset NN cord-015021-pol2qm74 6360 30 . . . cord-015021-pol2qm74 6361 1 There there EX cord-015021-pol2qm74 6361 2 was be VBD cord-015021-pol2qm74 6361 3 a a DT cord-015021-pol2qm74 6361 4 significant significant JJ cord-015021-pol2qm74 6361 5 correlation correlation NN cord-015021-pol2qm74 6361 6 between between IN cord-015021-pol2qm74 6361 7 the the DT cord-015021-pol2qm74 6361 8 peak peak NN cord-015021-pol2qm74 6361 9 serum serum NN cord-015021-pol2qm74 6361 10 IL-6 IL-6 NNP cord-015021-pol2qm74 6361 11 level level NN cord-015021-pol2qm74 6361 12 and and CC cord-015021-pol2qm74 6361 13 the the DT cord-015021-pol2qm74 6361 14 number number NN cord-015021-pol2qm74 6361 15 of of IN cord-015021-pol2qm74 6361 16 organs organ NNS cord-015021-pol2qm74 6361 17 showing show VBG cord-015021-pol2qm74 6361 18 failure failure NN cord-015021-pol2qm74 6361 19 ( ( -LRB- cord-015021-pol2qm74 6361 20 r=0.883 r=0.883 NNS cord-015021-pol2qm74 6361 21 ) ) -RRB- cord-015021-pol2qm74 6361 22 . . . cord-015021-pol2qm74 6362 1 TNF TNF NNP cord-015021-pol2qm74 6362 2 - - : cord-015021-pol2qm74 6362 3 a a DT cord-015021-pol2qm74 6362 4 production production NN cord-015021-pol2qm74 6362 5 by by IN cord-015021-pol2qm74 6362 6 isolated isolate VBN cord-015021-pol2qm74 6362 7 peritoneal peritoneal JJ cord-015021-pol2qm74 6362 8 macrophages macrophage NNS cord-015021-pol2qm74 6362 9 following follow VBG cord-015021-pol2qm74 6362 10 lipopolysaccharide lipopolysaccharide NN cord-015021-pol2qm74 6362 11 ( ( -LRB- cord-015021-pol2qm74 6362 12 LPS LPS NNP cord-015021-pol2qm74 6362 13 ) ) -RRB- cord-015021-pol2qm74 6362 14 stimulation stimulation NN cord-015021-pol2qm74 6362 15 was be VBD cord-015021-pol2qm74 6362 16 significantly significantly RB cord-015021-pol2qm74 6362 17 increased increase VBN cord-015021-pol2qm74 6362 18 in in IN cord-015021-pol2qm74 6362 19 cerulein cerulein NN cord-015021-pol2qm74 6362 20 - - HYPH cord-015021-pol2qm74 6362 21 induced induce VBN cord-015021-pol2qm74 6362 22 pancreatitis pancreatitis NN cord-015021-pol2qm74 6362 23 rats rat NNS cord-015021-pol2qm74 6362 24 . . . cord-015021-pol2qm74 6363 1 Serum serum NN cord-015021-pol2qm74 6363 2 TNF TNF NNP cord-015021-pol2qm74 6363 3 - - : cord-015021-pol2qm74 6363 4 a a DT cord-015021-pol2qm74 6363 5 activity activity NN cord-015021-pol2qm74 6363 6 was be VBD cord-015021-pol2qm74 6363 7 elevated elevate VBN cord-015021-pol2qm74 6363 8 following follow VBG cord-015021-pol2qm74 6363 9 intraperitoneal intraperitoneal JJ cord-015021-pol2qm74 6363 10 administration administration NN cord-015021-pol2qm74 6363 11 of of IN cord-015021-pol2qm74 6363 12 LPS LPS NNP cord-015021-pol2qm74 6363 13 as as IN cord-015021-pol2qm74 6363 14 the the DT cord-015021-pol2qm74 6363 15 septic septic JJ cord-015021-pol2qm74 6363 16 challenge challenge NN cord-015021-pol2qm74 6363 17 both both CC cord-015021-pol2qm74 6363 18 in in IN cord-015021-pol2qm74 6363 19 pancreatitis pancreatitis NN cord-015021-pol2qm74 6363 20 rats rat NNS cord-015021-pol2qm74 6363 21 and and CC cord-015021-pol2qm74 6363 22 in in IN cord-015021-pol2qm74 6363 23 control control NN cord-015021-pol2qm74 6363 24 rats rat NNS cord-015021-pol2qm74 6363 25 , , , cord-015021-pol2qm74 6363 26 being be VBG cord-015021-pol2qm74 6363 27 significantly significantly RB cord-015021-pol2qm74 6363 28 higher high JJR cord-015021-pol2qm74 6363 29 in in IN cord-015021-pol2qm74 6363 30 the the DT cord-015021-pol2qm74 6363 31 former former JJ cord-015021-pol2qm74 6363 32 ( ( -LRB- cord-015021-pol2qm74 6363 33 p<0.05 p<0.05 CD cord-015021-pol2qm74 6363 34 ) ) -RRB- cord-015021-pol2qm74 6363 35 . . . cord-015021-pol2qm74 6364 1 Histological histological JJ cord-015021-pol2qm74 6364 2 findings finding NNS cord-015021-pol2qm74 6364 3 and and CC cord-015021-pol2qm74 6364 4 liver liver NN cord-015021-pol2qm74 6364 5 function function NN cord-015021-pol2qm74 6364 6 tests test NNS cord-015021-pol2qm74 6364 7 revealed reveal VBD cord-015021-pol2qm74 6364 8 that that IN cord-015021-pol2qm74 6364 9 LPS LPS NNP cord-015021-pol2qm74 6364 10 induced induce VBD cord-015021-pol2qm74 6364 11 more more RBR cord-015021-pol2qm74 6364 12 severe severe JJ cord-015021-pol2qm74 6364 13 liver liver NN cord-015021-pol2qm74 6364 14 damage damage NN cord-015021-pol2qm74 6364 15 in in IN cord-015021-pol2qm74 6364 16 pancreatitis pancreatitis NN cord-015021-pol2qm74 6364 17 rats rat NNS cord-015021-pol2qm74 6364 18 than than IN cord-015021-pol2qm74 6364 19 in in IN cord-015021-pol2qm74 6364 20 control control NN cord-015021-pol2qm74 6364 21 rats rat NNS cord-015021-pol2qm74 6364 22 . . . cord-015021-pol2qm74 6365 1 These these DT cord-015021-pol2qm74 6365 2 results result NNS cord-015021-pol2qm74 6365 3 indicate indicate VBP cord-015021-pol2qm74 6365 4 that that IN cord-015021-pol2qm74 6365 5 increased increase VBN cord-015021-pol2qm74 6365 6 TNF TNF NNP cord-015021-pol2qm74 6365 7 - - : cord-015021-pol2qm74 6365 8 a a DT cord-015021-pol2qm74 6365 9 production production NN cord-015021-pol2qm74 6365 10 by by IN cord-015021-pol2qm74 6365 11 peritoneal peritoneal JJ cord-015021-pol2qm74 6365 12 macrophages macrophage NNS cord-015021-pol2qm74 6365 13 in in IN cord-015021-pol2qm74 6365 14 acute acute JJ cord-015021-pol2qm74 6365 15 pancreatitis pancreatitis NN cord-015021-pol2qm74 6365 16 augmented augment VBD cord-015021-pol2qm74 6365 17 LPS LPS NNP cord-015021-pol2qm74 6365 18 - - HYPH cord-015021-pol2qm74 6365 19 induced induce VBN cord-015021-pol2qm74 6365 20 liver liver NN cord-015021-pol2qm74 6365 21 injury injury NN cord-015021-pol2qm74 6365 22 . . . cord-015021-pol2qm74 6366 1 Organ organ NN cord-015021-pol2qm74 6366 2 failure failure NN cord-015021-pol2qm74 6366 3 in in IN cord-015021-pol2qm74 6366 4 severe severe JJ cord-015021-pol2qm74 6366 5 acute acute JJ cord-015021-pol2qm74 6366 6 pancreatitis pancreatitis NN cord-015021-pol2qm74 6366 7 could could MD cord-015021-pol2qm74 6366 8 be be VB cord-015021-pol2qm74 6366 9 caused cause VBN cord-015021-pol2qm74 6366 10 , , , cord-015021-pol2qm74 6366 11 at at IN cord-015021-pol2qm74 6366 12 least least JJS cord-015021-pol2qm74 6366 13 in in IN cord-015021-pol2qm74 6366 14 part part NN cord-015021-pol2qm74 6366 15 , , , cord-015021-pol2qm74 6366 16 by by IN cord-015021-pol2qm74 6366 17 increased increase VBN cord-015021-pol2qm74 6366 18 cytokine cytokine NN cord-015021-pol2qm74 6366 19 production production NN cord-015021-pol2qm74 6366 20 . . . cord-015021-pol2qm74 6367 1 It -PRON- PRP cord-015021-pol2qm74 6367 2 is be VBZ cord-015021-pol2qm74 6367 3 clear clear JJ cord-015021-pol2qm74 6367 4 now now RB cord-015021-pol2qm74 6367 5 , , , cord-015021-pol2qm74 6367 6 that that IN cord-015021-pol2qm74 6367 7 in in IN cord-015021-pol2qm74 6367 8 MODS MODS NNP cord-015021-pol2qm74 6367 9 , , , cord-015021-pol2qm74 6367 10 organ organ NN cord-015021-pol2qm74 6367 11 injury injury NN cord-015021-pol2qm74 6367 12 is be VBZ cord-015021-pol2qm74 6367 13 not not RB cord-015021-pol2qm74 6367 14 directly directly RB cord-015021-pol2qm74 6367 15 due due JJ cord-015021-pol2qm74 6367 16 to to IN cord-015021-pol2qm74 6367 17 exogenous exogenous JJ cord-015021-pol2qm74 6367 18 factors factor NNS cord-015021-pol2qm74 6367 19 , , , cord-015021-pol2qm74 6367 20 such such JJ cord-015021-pol2qm74 6367 21 as as IN cord-015021-pol2qm74 6367 22 bacteria bacteria NNS cord-015021-pol2qm74 6367 23 or or CC cord-015021-pol2qm74 6367 24 toxins toxin NNS cord-015021-pol2qm74 6367 25 , , , cord-015021-pol2qm74 6367 26 but but CC cord-015021-pol2qm74 6367 27 instead instead RB cord-015021-pol2qm74 6367 28 is be VBZ cord-015021-pol2qm74 6367 29 largely largely RB cord-015021-pol2qm74 6367 30 a a DT cord-015021-pol2qm74 6367 31 consequence consequence NN cord-015021-pol2qm74 6367 32 of of IN cord-015021-pol2qm74 6367 33 the the DT cord-015021-pol2qm74 6367 34 host host NN cord-015021-pol2qm74 6367 35 's 's POS cord-015021-pol2qm74 6367 36 own own JJ cord-015021-pol2qm74 6367 37 endogenously endogenously RB cord-015021-pol2qm74 6367 38 produced produce VBN cord-015021-pol2qm74 6367 39 mediators mediator NNS cord-015021-pol2qm74 6367 40 . . . cord-015021-pol2qm74 6368 1 There there EX cord-015021-pol2qm74 6368 2 is be VBZ cord-015021-pol2qm74 6368 3 an an DT cord-015021-pol2qm74 6368 4 extensive extensive JJ cord-015021-pol2qm74 6368 5 body body NN cord-015021-pol2qm74 6368 6 of of IN cord-015021-pol2qm74 6368 7 literature literature NN cord-015021-pol2qm74 6368 8 on on IN cord-015021-pol2qm74 6368 9 the the DT cord-015021-pol2qm74 6368 10 inhibition inhibition NN cord-015021-pol2qm74 6368 11 of of IN cord-015021-pol2qm74 6368 12 mediator mediator NN cord-015021-pol2qm74 6368 13 production production NN cord-015021-pol2qm74 6368 14 , , , cord-015021-pol2qm74 6368 15 release release NN cord-015021-pol2qm74 6368 16 and and CC cord-015021-pol2qm74 6368 17 action action NN cord-015021-pol2qm74 6368 18 in in IN cord-015021-pol2qm74 6368 19 different different JJ cord-015021-pol2qm74 6368 20 cascade cascade NN cord-015021-pol2qm74 6368 21 systems system NNS cord-015021-pol2qm74 6368 22 by by IN cord-015021-pol2qm74 6368 23 glucocorticoids glucocorticoid NNS cord-015021-pol2qm74 6368 24 . . . cord-015021-pol2qm74 6369 1 They -PRON- PRP cord-015021-pol2qm74 6369 2 can can MD cord-015021-pol2qm74 6369 3 serve serve VB cord-015021-pol2qm74 6369 4 as as IN cord-015021-pol2qm74 6369 5 a a DT cord-015021-pol2qm74 6369 6 host host NN cord-015021-pol2qm74 6369 7 protection protection NN cord-015021-pol2qm74 6369 8 against against IN cord-015021-pol2qm74 6369 9 overactive overactive JJ cord-015021-pol2qm74 6369 10 defense defense NN cord-015021-pol2qm74 6369 11 reactions reaction NNS cord-015021-pol2qm74 6369 12 if if IN cord-015021-pol2qm74 6369 13 used use VBN cord-015021-pol2qm74 6369 14 adequately adequately RB cord-015021-pol2qm74 6369 15 . . . cord-015021-pol2qm74 6370 1 A a DT cord-015021-pol2qm74 6370 2 new new JJ cord-015021-pol2qm74 6370 3 understanding understanding NN cord-015021-pol2qm74 6370 4 of of IN cord-015021-pol2qm74 6370 5 the the DT cord-015021-pol2qm74 6370 6 regulation regulation NN cord-015021-pol2qm74 6370 7 of of IN cord-015021-pol2qm74 6370 8 cytokine cytokine NN cord-015021-pol2qm74 6370 9 synthesis synthesis NN cord-015021-pol2qm74 6370 10 , , , cord-015021-pol2qm74 6370 11 especially especially RB cord-015021-pol2qm74 6370 12 TNF TNF NNP cord-015021-pol2qm74 6370 13 , , , cord-015021-pol2qm74 6370 14 may may MD cord-015021-pol2qm74 6370 15 lead lead VB cord-015021-pol2qm74 6370 16 to to IN cord-015021-pol2qm74 6370 17 an an DT cord-015021-pol2qm74 6370 18 insight insight NN cord-015021-pol2qm74 6370 19 of of IN cord-015021-pol2qm74 6370 20 the the DT cord-015021-pol2qm74 6370 21 conflicting conflict VBG cord-015021-pol2qm74 6370 22 findings finding NNS cord-015021-pol2qm74 6370 23 between between IN cord-015021-pol2qm74 6370 24 the the DT cord-015021-pol2qm74 6370 25 benefits benefit NNS cord-015021-pol2qm74 6370 26 of of IN cord-015021-pol2qm74 6370 27 glucocorticoid glucocorticoid NN cord-015021-pol2qm74 6370 28 therapy therapy NN cord-015021-pol2qm74 6370 29 in in IN cord-015021-pol2qm74 6370 30 animals animal NNS cord-015021-pol2qm74 6370 31 and and CC cord-015021-pol2qm74 6370 32 its -PRON- PRP$ cord-015021-pol2qm74 6370 33 current current JJ cord-015021-pol2qm74 6370 34 failure failure NN cord-015021-pol2qm74 6370 35 in in IN cord-015021-pol2qm74 6370 36 recent recent JJ cord-015021-pol2qm74 6370 37 clinical clinical JJ cord-015021-pol2qm74 6370 38 trials trial NNS cord-015021-pol2qm74 6370 39 . . . cord-015021-pol2qm74 6371 1 Glucocorticoid Glucocorticoid NNP cord-015021-pol2qm74 6371 2 shares share VBZ cord-015021-pol2qm74 6371 3 its -PRON- PRP$ cord-015021-pol2qm74 6371 4 role role NN cord-015021-pol2qm74 6371 5 with with IN cord-015021-pol2qm74 6371 6 other other JJ cord-015021-pol2qm74 6371 7 novel novel JJ cord-015021-pol2qm74 6371 8 therapeutic therapeutic JJ cord-015021-pol2qm74 6371 9 approaches approach NNS cord-015021-pol2qm74 6372 1 also also RB cord-015021-pol2qm74 6372 2 shown show VBN cord-015021-pol2qm74 6372 3 to to TO cord-015021-pol2qm74 6372 4 be be VB cord-015021-pol2qm74 6372 5 successful successful JJ cord-015021-pol2qm74 6372 6 only only RB cord-015021-pol2qm74 6372 7 in in IN cord-015021-pol2qm74 6372 8 experimental experimental JJ cord-015021-pol2qm74 6372 9 settings setting NNS cord-015021-pol2qm74 6372 10 . . . cord-015021-pol2qm74 6373 1 A a DT cord-015021-pol2qm74 6373 2 mete mete NN cord-015021-pol2qm74 6373 3 - - HYPH cord-015021-pol2qm74 6373 4 analysis analysis NN cord-015021-pol2qm74 6373 5 of of IN cord-015021-pol2qm74 6373 6 steroids steroid NNS cord-015021-pol2qm74 6373 7 in in IN cord-015021-pol2qm74 6373 8 sepsis sepsis NN cord-015021-pol2qm74 6373 9 , , , cord-015021-pol2qm74 6373 10 however however RB cord-015021-pol2qm74 6373 11 , , , cord-015021-pol2qm74 6373 12 revealed reveal VBD cord-015021-pol2qm74 6373 13 a a DT cord-015021-pol2qm74 6373 14 beneficial beneficial JJ cord-015021-pol2qm74 6373 15 effect effect NN cord-015021-pol2qm74 6373 16 in in IN cord-015021-pol2qm74 6373 17 the the DT cord-015021-pol2qm74 6373 18 subgroup subgroup NN cord-015021-pol2qm74 6373 19 of of IN cord-015021-pol2qm74 6373 20 patients patient NNS cord-015021-pol2qm74 6373 21 with with IN cord-015021-pol2qm74 6373 22 gram gram JJ cord-015021-pol2qm74 6373 23 - - HYPH cord-015021-pol2qm74 6373 24 negative negative JJ cord-015021-pol2qm74 6373 25 infections infection NNS cord-015021-pol2qm74 6373 26 . . . cord-015021-pol2qm74 6374 1 There there EX cord-015021-pol2qm74 6374 2 is be VBZ cord-015021-pol2qm74 6374 3 now now RB cord-015021-pol2qm74 6374 4 a a DT cord-015021-pol2qm74 6374 5 series series NN cord-015021-pol2qm74 6374 6 of of IN cord-015021-pol2qm74 6374 7 arguments argument NNS cord-015021-pol2qm74 6374 8 to to TO cord-015021-pol2qm74 6374 9 reevaluate reevaluate VB cord-015021-pol2qm74 6374 10 the the DT cord-015021-pol2qm74 6374 11 indication indication NN cord-015021-pol2qm74 6374 12 for for IN cord-015021-pol2qm74 6374 13 steroid steroid NN cord-015021-pol2qm74 6374 14 thera thera NN cord-015021-pol2qm74 6374 15 - - HYPH cord-015021-pol2qm74 6374 16 py py NN cord-015021-pol2qm74 6374 17 and/or and/or CC cord-015021-pol2qm74 6374 18 prophylaxis prophylaxis NN cord-015021-pol2qm74 6374 19 in in IN cord-015021-pol2qm74 6374 20 MODS mods NN cord-015021-pol2qm74 6374 21 and and CC cord-015021-pol2qm74 6374 22 sepsis sepsis NN cord-015021-pol2qm74 6374 23 . . . cord-015021-pol2qm74 6375 1 Honjo Honjo NNP cord-015021-pol2qm74 6375 2 i-1 i-1 NNP cord-015021-pol2qm74 6375 3 - - HYPH cord-015021-pol2qm74 6375 4 1 1 CD cord-015021-pol2qm74 6375 5 , , , cord-015021-pol2qm74 6375 6 Kumamoto Kumamoto NNP cord-015021-pol2qm74 6375 7 860 860 CD cord-015021-pol2qm74 6376 1 , , , cord-015021-pol2qm74 6376 2 Japan Japan NNP cord-015021-pol2qm74 6376 3 IN in IN cord-015021-pol2qm74 6376 4 SEPTIC septic JJ cord-015021-pol2qm74 6376 5 SHOCK shock NN cord-015021-pol2qm74 6376 6 J. J. NNP cord-015021-pol2qm74 6376 7 Briegel Briegel NNP cord-015021-pol2qm74 6376 8 , , , cord-015021-pol2qm74 6376 9 M. M. NNP cord-015021-pol2qm74 6376 10 Halter Halter NNP cord-015021-pol2qm74 6376 11 , , , cord-015021-pol2qm74 6376 12 H. H. NNP cord-015021-pol2qm74 6376 13 Forst Forst NNP cord-015021-pol2qm74 6376 14 , , , cord-015021-pol2qm74 6376 15 W. W. NNP cord-015021-pol2qm74 6376 16 Kellermaun Kellermaun NNP cord-015021-pol2qm74 6376 17 , , , cord-015021-pol2qm74 6376 18 M. M. NNP cord-015021-pol2qm74 6376 19 Bittl Bittl NNP cord-015021-pol2qm74 6376 20 , , , cord-015021-pol2qm74 6376 21 K. K. NNP cord-015021-pol2qm74 6376 22 Peter Peter NNP cord-015021-pol2qm74 6376 23 Imrodnetlea Imrodnetlea NNP cord-015021-pol2qm74 6376 24 and and CC cord-015021-pol2qm74 6376 25 Methods method NNS cord-015021-pol2qm74 6376 26 : : : cord-015021-pol2qm74 6376 27 Hydrocortisone Hydrocortisone NNP cord-015021-pol2qm74 6376 28 ( ( -LRB- cord-015021-pol2qm74 6376 29 HC HC NNP cord-015021-pol2qm74 6376 30 ) ) -RRB- cord-015021-pol2qm74 6376 31 at at IN cord-015021-pol2qm74 6376 32 an an DT cord-015021-pol2qm74 6376 33 infusion infusion NN cord-015021-pol2qm74 6376 34 rate rate NN cord-015021-pol2qm74 6376 35 similar similar JJ cord-015021-pol2qm74 6376 36 to to IN cord-015021-pol2qm74 6376 37 the the DT cord-015021-pol2qm74 6376 38 maximal maximal JJ cord-015021-pol2qm74 6376 39 secretory secretory JJ cord-015021-pol2qm74 6376 40 rate rate NN cord-015021-pol2qm74 6376 41 of of IN cord-015021-pol2qm74 6376 42 cortisol cortisol NN cord-015021-pol2qm74 6376 43 in in IN cord-015021-pol2qm74 6376 44 man man NN cord-015021-pol2qm74 6376 45 improves improve VBZ cord-015021-pol2qm74 6376 46 hemodynamics hemodynamic NNS cord-015021-pol2qm74 6376 47 in in IN cord-015021-pol2qm74 6376 48 human human JJ cord-015021-pol2qm74 6376 49 septic septic JJ cord-015021-pol2qm74 6376 50 shock shock NN cord-015021-pol2qm74 6376 51 ( ( -LRB- cord-015021-pol2qm74 6376 52 1 1 CD cord-015021-pol2qm74 6376 53 ) ) -RRB- cord-015021-pol2qm74 6376 54 . . . cord-015021-pol2qm74 6377 1 We -PRON- PRP cord-015021-pol2qm74 6377 2 hypothesized hypothesize VBD cord-015021-pol2qm74 6377 3 that that IN cord-015021-pol2qm74 6377 4 the the DT cord-015021-pol2qm74 6377 5 HC HC NNP cord-015021-pol2qm74 6377 6 - - HYPH cord-015021-pol2qm74 6377 7 induced induce VBN cord-015021-pol2qm74 6377 8 hypercortisolemia hypercortisolemia NN cord-015021-pol2qm74 6377 9 prevents prevent VBZ cord-015021-pol2qm74 6377 10 a a DT cord-015021-pol2qm74 6377 11 harmful harmful JJ cord-015021-pol2qm74 6377 12 overshoot overshoot NN cord-015021-pol2qm74 6377 13 of of IN cord-015021-pol2qm74 6377 14 immune immune JJ cord-015021-pol2qm74 6377 15 reactions reaction NNS cord-015021-pol2qm74 6377 16 . . . cord-015021-pol2qm74 6378 1 To to TO cord-015021-pol2qm74 6378 2 test test VB cord-015021-pol2qm74 6378 3 this this DT cord-015021-pol2qm74 6378 4 hypothesis hypothesis NN cord-015021-pol2qm74 6378 5 we -PRON- PRP cord-015021-pol2qm74 6378 6 prospectively prospectively RB cord-015021-pol2qm74 6378 7 investigated investigate VBD cord-015021-pol2qm74 6378 8 12 12 CD cord-015021-pol2qm74 6378 9 patients patient NNS cord-015021-pol2qm74 6378 10 admitted admit VBN cord-015021-pol2qm74 6378 11 to to IN cord-015021-pol2qm74 6378 12 the the DT cord-015021-pol2qm74 6378 13 ICU ICU NNP cord-015021-pol2qm74 6378 14 in in IN cord-015021-pol2qm74 6378 15 refractory refractory JJ cord-015021-pol2qm74 6378 16 septic septic JJ cord-015021-pol2qm74 6378 17 shock shock NN cord-015021-pol2qm74 6378 18 . . . cord-015021-pol2qm74 6379 1 After after IN cord-015021-pol2qm74 6379 2 resuscitation resuscitation NN cord-015021-pol2qm74 6379 3 ( ( -LRB- cord-015021-pol2qm74 6379 4 mechanical mechanical JJ cord-015021-pol2qm74 6379 5 ventilation ventilation NN cord-015021-pol2qm74 6379 6 , , , cord-015021-pol2qm74 6379 7 fluid fluid JJ cord-015021-pol2qm74 6379 8 resuscitation resuscitation NN cord-015021-pol2qm74 6379 9 , , , cord-015021-pol2qm74 6379 10 titration titration NN cord-015021-pol2qm74 6379 11 of of IN cord-015021-pol2qm74 6379 12 vasopressors vasopressor NNS cord-015021-pol2qm74 6379 13 , , , cord-015021-pol2qm74 6379 14 and and CC cord-015021-pol2qm74 6379 15 initiation initiation NN cord-015021-pol2qm74 6379 16 of of IN cord-015021-pol2qm74 6379 17 antimicrobial antimicrobial JJ cord-015021-pol2qm74 6379 18 therapy therapy NN cord-015021-pol2qm74 6379 19 ) ) -RRB- cord-015021-pol2qm74 6380 1 HC HC NNP cord-015021-pol2qm74 6380 2 Was be VBD cord-015021-pol2qm74 6380 3 started start VBN cord-015021-pol2qm74 6380 4 with with IN cord-015021-pol2qm74 6380 5 a a DT cord-015021-pol2qm74 6380 6 loading loading NN cord-015021-pol2qm74 6380 7 dose dose NN cord-015021-pol2qm74 6380 8 of of IN cord-015021-pol2qm74 6380 9 100 100 CD cord-015021-pol2qm74 6380 10 mg/ mg/ NN cord-015021-pol2qm74 6380 11 30 30 CD cord-015021-pol2qm74 6380 12 rain rain NN cord-015021-pol2qm74 6380 13 , , , cord-015021-pol2qm74 6380 14 followed follow VBN cord-015021-pol2qm74 6380 15 by by IN cord-015021-pol2qm74 6380 16 a a DT cord-015021-pol2qm74 6380 17 continuous continuous JJ cord-015021-pol2qm74 6380 18 infusion infusion NN cord-015021-pol2qm74 6380 19 ( ( -LRB- cord-015021-pol2qm74 6380 20 10 10 CD cord-015021-pol2qm74 6380 21 mggh mggh NNS cord-015021-pol2qm74 6380 22 ) ) -RRB- cord-015021-pol2qm74 6380 23 . . . cord-015021-pol2qm74 6381 1 With with IN cord-015021-pol2qm74 6381 2 hemodynamic hemodynamic JJ cord-015021-pol2qm74 6381 3 improvement improvement NN cord-015021-pol2qm74 6381 4 ( ( -LRB- cord-015021-pol2qm74 6381 5 dopamine dopamine NN cord-015021-pol2qm74 6381 6 < < XX cord-015021-pol2qm74 6381 7 2 2 CD cord-015021-pol2qm74 6381 8 gg gg NNP cord-015021-pol2qm74 6381 9 / / SYM cord-015021-pol2qm74 6381 10 kg kg NNP cord-015021-pol2qm74 6381 11 / / SYM cord-015021-pol2qm74 6381 12 min min NN cord-015021-pol2qm74 6381 13 ) ) -RRB- cord-015021-pol2qm74 6381 14 the the DT cord-015021-pol2qm74 6381 15 infusion infusion NN cord-015021-pol2qm74 6381 16 rate rate NN cord-015021-pol2qm74 6381 17 nfHC nfhc NN cord-015021-pol2qm74 6381 18 was be VBD cord-015021-pol2qm74 6381 19 tapered taper VBN cord-015021-pol2qm74 6381 20 over over IN cord-015021-pol2qm74 6381 21 a a DT cord-015021-pol2qm74 6381 22 period period NN cord-015021-pol2qm74 6381 23 of of IN cord-015021-pol2qm74 6381 24 3 3 CD cord-015021-pol2qm74 6381 25 days day NNS cord-015021-pol2qm74 6381 26 . . . cord-015021-pol2qm74 6382 1 Phospbolipase Phospbolipase NNP cord-015021-pol2qm74 6382 2 A a DT cord-015021-pol2qm74 6382 3 2 2 CD cord-015021-pol2qm74 6382 4 ( ( -LRB- cord-015021-pol2qm74 6382 5 PLA2 PLA2 NNP cord-015021-pol2qm74 6382 6 ) ) -RRB- cord-015021-pol2qm74 6382 7 , , , cord-015021-pol2qm74 6382 8 C c NN cord-015021-pol2qm74 6382 9 - - HYPH cord-015021-pol2qm74 6382 10 reactive reactive JJ cord-015021-pol2qm74 6382 11 protein protein NN cord-015021-pol2qm74 6382 12 ( ( -LRB- cord-015021-pol2qm74 6382 13 CRP CRP NNP cord-015021-pol2qm74 6382 14 ) ) -RRB- cord-015021-pol2qm74 6382 15 , , , cord-015021-pol2qm74 6382 16 and and CC cord-015021-pol2qm74 6382 17 elastase elastase NN cord-015021-pol2qm74 6382 18 - - HYPH cord-015021-pol2qm74 6382 19 proteinase proteinase NN cord-015021-pol2qm74 6382 20 inhibitor inhibitor NN cord-015021-pol2qm74 6382 21 complex complex NN cord-015021-pol2qm74 6383 1 ( ( -LRB- cord-015021-pol2qm74 6383 2 E e NN cord-015021-pol2qm74 6383 3 - - NN cord-015021-pol2qm74 6383 4 PI pi NN cord-015021-pol2qm74 6383 5 ) ) -RRB- cord-015021-pol2qm74 6383 6 were be VBD cord-015021-pol2qm74 6383 7 deierminated deierminate VBN cord-015021-pol2qm74 6383 8 daily daily RB cord-015021-pol2qm74 6383 9 . . . cord-015021-pol2qm74 6384 1 Results result NNS cord-015021-pol2qm74 6384 2 : : : cord-015021-pol2qm74 6385 1 According accord VBG cord-015021-pol2qm74 6385 2 to to IN cord-015021-pol2qm74 6385 3 our -PRON- PRP$ cord-015021-pol2qm74 6385 4 previous previous JJ cord-015021-pol2qm74 6385 5 results result NNS cord-015021-pol2qm74 6385 6 hemodynamics hemodynamic NNS cord-015021-pol2qm74 6385 7 improved improve VBD cord-015021-pol2qm74 6385 8 during during IN cord-015021-pol2qm74 6385 9 HC HC NNP cord-015021-pol2qm74 6385 10 infusien infusien NNP cord-015021-pol2qm74 6385 11 . . . cord-015021-pol2qm74 6386 1 After after IN cord-015021-pol2qm74 6386 2 4 4 CD cord-015021-pol2qm74 6386 3 days day NNS cord-015021-pol2qm74 6386 4 dopamine dopamine NN cord-015021-pol2qm74 6386 5 requirements requirement NNS cord-015021-pol2qm74 6386 6 decreased decrease VBD cord-015021-pol2qm74 6386 7 to to IN cord-015021-pol2qm74 6386 8 less less JJR cord-015021-pol2qm74 6386 9 than than IN cord-015021-pol2qm74 6386 10 2 2 CD cord-015021-pol2qm74 6386 11 gg&g gg&g NNP cord-015021-pol2qm74 6386 12 / / SYM cord-015021-pol2qm74 6386 13 min min NN cord-015021-pol2qm74 6386 14 in in IN cord-015021-pol2qm74 6386 15 all all DT cord-015021-pol2qm74 6386 16 patients patient NNS cord-015021-pol2qm74 6386 17 . . . cord-015021-pol2qm74 6387 1 This this DT cord-015021-pol2qm74 6387 2 corresponded correspond VBD cord-015021-pol2qm74 6387 3 to to IN cord-015021-pol2qm74 6387 4 an an DT cord-015021-pol2qm74 6387 5 attenuation attenuation NN cord-015021-pol2qm74 6387 6 of of IN cord-015021-pol2qm74 6387 7 the the DT cord-015021-pol2qm74 6387 8 systemic systemic JJ cord-015021-pol2qm74 6387 9 inflammatory inflammatory JJ cord-015021-pol2qm74 6387 10 response response NN cord-015021-pol2qm74 6387 11 syndrome syndrome NN cord-015021-pol2qm74 6387 12 ( ( -LRB- cord-015021-pol2qm74 6387 13 SIRS SIRS NNP cord-015021-pol2qm74 6387 14 ) ) -RRB- cord-015021-pol2qm74 6387 15 indicated indicate VBN cord-015021-pol2qm74 6387 16 by by IN cord-015021-pol2qm74 6387 17 the the DT cord-015021-pol2qm74 6387 18 abrogation abrogation NN cord-015021-pol2qm74 6387 19 of of IN cord-015021-pol2qm74 6387 20 fever fever NN cord-015021-pol2qm74 6387 21 and and CC cord-015021-pol2qm74 6387 22 the the DT cord-015021-pol2qm74 6387 23 decrease decrease NN cord-015021-pol2qm74 6387 24 in in IN cord-015021-pol2qm74 6387 25 heart heart NN cord-015021-pol2qm74 6387 26 rate rate NN cord-015021-pol2qm74 6387 27 and and CC cord-015021-pol2qm74 6387 28 inflammatory inflammatory JJ cord-015021-pol2qm74 6387 29 mediators mediator NNS cord-015021-pol2qm74 6387 30 . . . cord-015021-pol2qm74 6388 1 PLA PLA NNP cord-015021-pol2qm74 6388 2 2 2 CD cord-015021-pol2qm74 6388 3 activity activity NN cord-015021-pol2qm74 6388 4 and and CC cord-015021-pol2qm74 6388 5 E e NN cord-015021-pol2qm74 6388 6 - - JJ cord-015021-pol2qm74 6388 7 PI pi JJ cord-015021-pol2qm74 6388 8 concentrations concentration NNS cord-015021-pol2qm74 6388 9 decreased decrease VBD cord-015021-pol2qm74 6388 10 to to IN cord-015021-pol2qm74 6388 11 near near IN cord-015021-pol2qm74 6388 12 normal normal JJ cord-015021-pol2qm74 6388 13 values value NNS cord-015021-pol2qm74 6388 14 and and CC cord-015021-pol2qm74 6388 15 CRP crp NN cord-015021-pol2qm74 6388 16 concentrations concentration NNS cord-015021-pol2qm74 6388 17 decreased decrease VBD cord-015021-pol2qm74 6388 18 as as RB cord-015021-pol2qm74 6388 19 well well RB cord-015021-pol2qm74 6388 20 . . . cord-015021-pol2qm74 6389 1 After after IN cord-015021-pol2qm74 6389 2 cessation cessation NN cord-015021-pol2qm74 6389 3 of of IN cord-015021-pol2qm74 6389 4 HC HC NNP cord-015021-pol2qm74 6389 5 infusion infusion NN cord-015021-pol2qm74 6389 6 ( ( -LRB- cord-015021-pol2qm74 6389 7 between between IN cord-015021-pol2qm74 6389 8 day day NN cord-015021-pol2qm74 6389 9 5 5 CD cord-015021-pol2qm74 6389 10 and and CC cord-015021-pol2qm74 6389 11 7 7 CD cord-015021-pol2qm74 6389 12 ) ) -RRB- cord-015021-pol2qm74 6389 13 a a DT cord-015021-pol2qm74 6389 14 reinforcement reinforcement NN cord-015021-pol2qm74 6389 15 nfthe nfthe JJS cord-015021-pol2qm74 6389 16 SIRS SIRS NNP cord-015021-pol2qm74 6389 17 was be VBD cord-015021-pol2qm74 6389 18 observed observe VBN cord-015021-pol2qm74 6389 19 despite despite IN cord-015021-pol2qm74 6389 20 cortisol cortisol NN cord-015021-pol2qm74 6389 21 levels level NNS cord-015021-pol2qm74 6389 22 within within IN cord-015021-pol2qm74 6389 23 the the DT cord-015021-pol2qm74 6389 24 normal normal JJ cord-015021-pol2qm74 6389 25 range range NN cord-015021-pol2qm74 6389 26 . . . cord-015021-pol2qm74 6390 1 This this DT cord-015021-pol2qm74 6390 2 was be VBD cord-015021-pol2qm74 6390 3 first first RB cord-015021-pol2qm74 6390 4 indicated indicate VBN cord-015021-pol2qm74 6390 5 by by IN cord-015021-pol2qm74 6390 6 E e NN cord-015021-pol2qm74 6390 7 - - NN cord-015021-pol2qm74 6390 8 PI pi NN cord-015021-pol2qm74 6390 9 , , , cord-015021-pol2qm74 6390 10 followed follow VBN cord-015021-pol2qm74 6390 11 by by IN cord-015021-pol2qm74 6390 12 fever fever NN cord-015021-pol2qm74 6390 13 , , , cord-015021-pol2qm74 6390 14 increases increase NNS cord-015021-pol2qm74 6390 15 in in IN cord-015021-pol2qm74 6390 16 heart heart NN cord-015021-pol2qm74 6390 17 rate rate NN cord-015021-pol2qm74 6390 18 , , , cord-015021-pol2qm74 6390 19 CRP CRP NNP cord-015021-pol2qm74 6390 20 , , , cord-015021-pol2qm74 6390 21 PLA2 PLA2 NNP cord-015021-pol2qm74 6390 22 , , , cord-015021-pol2qm74 6390 23 and and CC cord-015021-pol2qm74 6390 24 finally finally RB cord-015021-pol2qm74 6390 25 by by IN cord-015021-pol2qm74 6390 26 the the DT cord-015021-pol2qm74 6390 27 relapse relapse NN cord-015021-pol2qm74 6390 28 of of IN cord-015021-pol2qm74 6390 29 septic septic JJ cord-015021-pol2qm74 6390 30 shock shock NN cord-015021-pol2qm74 6390 31 in in IN cord-015021-pol2qm74 6390 32 four four CD cord-015021-pol2qm74 6390 33 patients patient NNS cord-015021-pol2qm74 6390 34 on on IN cord-015021-pol2qm74 6390 35 days day NNS cord-015021-pol2qm74 6390 36 7,8 7,8 CD cord-015021-pol2qm74 6390 37 9 9 CD cord-015021-pol2qm74 6390 38 , , , cord-015021-pol2qm74 6390 39 and and CC cord-015021-pol2qm74 6390 40 1O. 1o. CD cord-015021-pol2qm74 6390 41 A a DT cord-015021-pol2qm74 6390 42 second second JJ cord-015021-pol2qm74 6390 43 infusion infusion NN cord-015021-pol2qm74 6390 44 of of IN cord-015021-pol2qm74 6390 45 HC HC NNP cord-015021-pol2qm74 6390 46 again again RB cord-015021-pol2qm74 6390 47 resulted result VBD cord-015021-pol2qm74 6390 48 in in IN cord-015021-pol2qm74 6390 49 shock shock NN cord-015021-pol2qm74 6390 50 reversal reversal NN cord-015021-pol2qm74 6390 51 and and CC cord-015021-pol2qm74 6390 52 in in IN cord-015021-pol2qm74 6390 53 a a DT cord-015021-pol2qm74 6390 54 decrease decrease NN cord-015021-pol2qm74 6390 55 in in IN cord-015021-pol2qm74 6390 56 PLA2 PLA2 NNP cord-015021-pol2qm74 6390 57 , , , cord-015021-pol2qm74 6390 58 CRP CRP NNP cord-015021-pol2qm74 6390 59 , , , cord-015021-pol2qm74 6390 60 and and CC cord-015021-pol2qm74 6390 61 E e NN cord-015021-pol2qm74 6390 62 - - NN cord-015021-pol2qm74 6390 63 PI pi NN cord-015021-pol2qm74 6390 64 in in IN cord-015021-pol2qm74 6390 65 the the DT cord-015021-pol2qm74 6390 66 patients patient NNS cord-015021-pol2qm74 6390 67 under under IN cord-015021-pol2qm74 6390 68 study study NN cord-015021-pol2qm74 6390 69 . . . cord-015021-pol2qm74 6391 1 Discussion discussion NN cord-015021-pol2qm74 6391 2 : : : cord-015021-pol2qm74 6392 1 There there EX cord-015021-pol2qm74 6392 2 is be VBZ cord-015021-pol2qm74 6392 3 growing grow VBG cord-015021-pol2qm74 6392 4 evidence evidence NN cord-015021-pol2qm74 6392 5 that that IN cord-015021-pol2qm74 6392 6 the the DT cord-015021-pol2qm74 6392 7 endogenous endogenous JJ cord-015021-pol2qm74 6392 8 steroid steroid NN cord-015021-pol2qm74 6392 9 HC hc NN cord-015021-pol2qm74 6392 10 and and CC cord-015021-pol2qm74 6392 11 proinflammatory proinflammatory JJ cord-015021-pol2qm74 6392 12 cytokines cytokine NNS cord-015021-pol2qm74 6392 13 integrate integrate VBP cord-015021-pol2qm74 6392 14 a a DT cord-015021-pol2qm74 6392 15 complex complex JJ cord-015021-pol2qm74 6392 16 immunoregulatory immunoregulatory NN cord-015021-pol2qm74 6392 17 feec feec NNP cord-015021-pol2qm74 6392 18 ~ ~ NFP cord-015021-pol2qm74 6392 19 ack ack NNP cord-015021-pol2qm74 6392 20 circuit circuit NN cord-015021-pol2qm74 6392 21 . . . cord-015021-pol2qm74 6393 1 The the DT cord-015021-pol2qm74 6393 2 elaboration elaboration NN cord-015021-pol2qm74 6393 3 of of IN cord-015021-pol2qm74 6393 4 TNF TNF NNP cord-015021-pol2qm74 6393 5 , , , cord-015021-pol2qm74 6393 6 IL-16 IL-16 NNP cord-015021-pol2qm74 6393 7 , , , cord-015021-pol2qm74 6393 8 IL-6 IL-6 NNP cord-015021-pol2qm74 6393 9 , , , cord-015021-pol2qm74 6393 10 and and CC cord-015021-pol2qm74 6393 11 IL-8 IL-8 NNP cord-015021-pol2qm74 6393 12 is be VBZ cord-015021-pol2qm74 6393 13 attenuated attenuate VBN cord-015021-pol2qm74 6393 14 by-100 by-100 NNP cord-015021-pol2qm74 6393 15 rag rag NN cord-015021-pol2qm74 6393 16 HC HC NNP cord-015021-pol2qm74 6393 17 prior prior RB cord-015021-pol2qm74 6393 18 to to IN cord-015021-pol2qm74 6393 19 endotoxin endotoxin NN cord-015021-pol2qm74 6393 20 challenge challenge NN cord-015021-pol2qm74 6393 21 in in IN cord-015021-pol2qm74 6393 22 humans human NNS cord-015021-pol2qm74 6393 23 ( ( -LRB- cord-015021-pol2qm74 6393 24 2 2 CD cord-015021-pol2qm74 6393 25 , , , cord-015021-pol2qm74 6393 26 3 3 CD cord-015021-pol2qm74 6393 27 ) ) -RRB- cord-015021-pol2qm74 6393 28 . . . cord-015021-pol2qm74 6394 1 Cytokines Cytokines NNP cord-015021-pol2qm74 6394 2 like like IN cord-015021-pol2qm74 6394 3 TNF TNF NNP cord-015021-pol2qm74 6394 4 , , , cord-015021-pol2qm74 6394 5 IL-16 IL-16 NNP cord-015021-pol2qm74 6394 6 , , , cord-015021-pol2qm74 6394 7 IL-6 IL-6 NNP cord-015021-pol2qm74 6394 8 , , , cord-015021-pol2qm74 6394 9 and and CC cord-015021-pol2qm74 6394 10 IL-8 IL-8 NNP cord-015021-pol2qm74 6394 11 are be VBP cord-015021-pol2qm74 6394 12 potent potent JJ cord-015021-pol2qm74 6394 13 proinflammatory proinflammatory JJ cord-015021-pol2qm74 6394 14 signals signal NNS cord-015021-pol2qm74 6394 15 for for IN cord-015021-pol2qm74 6394 16 acute acute JJ cord-015021-pol2qm74 6394 17 reactants reactant NNS cord-015021-pol2qm74 6394 18 ( ( -LRB- cord-015021-pol2qm74 6394 19 -- -- : cord-015021-pol2qm74 6394 20 , , , cord-015021-pol2qm74 6394 21 CLIP CLIP NNP cord-015021-pol2qm74 6394 22 ) ) -RRB- cord-015021-pol2qm74 6394 23 , , , cord-015021-pol2qm74 6394 24 neutrophil neutrophil NN cord-015021-pol2qm74 6394 25 degranulation degranulation NN cord-015021-pol2qm74 6394 26 ( ( -LRB- cord-015021-pol2qm74 6394 27 -- -- : cord-015021-pol2qm74 6394 28 , , , cord-015021-pol2qm74 6394 29 E e NN cord-015021-pol2qm74 6394 30 - - NN cord-015021-pol2qm74 6394 31 PI PI NNP cord-015021-pol2qm74 6394 32 ) ) -RRB- cord-015021-pol2qm74 6394 33 , , , cord-015021-pol2qm74 6394 34 and and CC cord-015021-pol2qm74 6394 35 PLA PLA NNP cord-015021-pol2qm74 6394 36 2 2 CD cord-015021-pol2qm74 6394 37 synthesis synthesis NN cord-015021-pol2qm74 6394 38 and and CC cord-015021-pol2qm74 6394 39 secretion secretion NN cord-015021-pol2qm74 6394 40 . . . cord-015021-pol2qm74 6395 1 Our -PRON- PRP$ cord-015021-pol2qm74 6395 2 data datum NNS cord-015021-pol2qm74 6395 3 provide provide VBP cord-015021-pol2qm74 6395 4 evidence evidence NN cord-015021-pol2qm74 6395 5 that that IN cord-015021-pol2qm74 6395 6 HC HC NNP cord-015021-pol2qm74 6395 7 at at IN cord-015021-pol2qm74 6395 8 an an DT cord-015021-pol2qm74 6395 9 infusion infusion NN cord-015021-pol2qm74 6395 10 rate rate NN cord-015021-pol2qm74 6395 11 similar similar JJ cord-015021-pol2qm74 6395 12 to to IN cord-015021-pol2qm74 6395 13 the the DT cord-015021-pol2qm74 6395 14 maximal maximal JJ cord-015021-pol2qm74 6395 15 secretory secretory JJ cord-015021-pol2qm74 6395 16 rate rate NN cord-015021-pol2qm74 6395 17 of of IN cord-015021-pol2qm74 6395 18 cortisol cortisol NN cord-015021-pol2qm74 6395 19 in in IN cord-015021-pol2qm74 6395 20 man man NN cord-015021-pol2qm74 6395 21 attenuates attenuate VBZ cord-015021-pol2qm74 6395 22 the the DT cord-015021-pol2qm74 6395 23 systemic systemic JJ cord-015021-pol2qm74 6395 24 inflammatory inflammatory JJ cord-015021-pol2qm74 6395 25 response response NN cord-015021-pol2qm74 6395 26 in in IN cord-015021-pol2qm74 6395 27 human human JJ cord-015021-pol2qm74 6395 28 septic septic JJ cord-015021-pol2qm74 6395 29 shock shock NN cord-015021-pol2qm74 6395 30 . . . cord-015021-pol2qm74 6396 1 To to TO cord-015021-pol2qm74 6396 2 evaluate evaluate VB cord-015021-pol2qm74 6396 3 the the DT cord-015021-pol2qm74 6396 4 feasibility feasibility NN cord-015021-pol2qm74 6396 5 of of IN cord-015021-pol2qm74 6396 6 a a DT cord-015021-pol2qm74 6396 7 nigh nigh JJ cord-015021-pol2qm74 6396 8 - - HYPH cord-015021-pol2qm74 6396 9 dose dose NN cord-015021-pol2qm74 6396 10 regimen regimen NN cord-015021-pol2qm74 6396 11 of of IN cord-015021-pol2qm74 6396 12 antithrombin antithrombin NN cord-015021-pol2qm74 6396 13 III III NNP cord-015021-pol2qm74 6396 14 ( ( -LRB- cord-015021-pol2qm74 6396 15 AT at IN cord-015021-pol2qm74 6396 16 III III NNP cord-015021-pol2qm74 6396 17 ) ) -RRB- cord-015021-pol2qm74 6396 18 treatment treatment NN cord-015021-pol2qm74 6396 19 in in IN cord-015021-pol2qm74 6396 20 patients patient NNS cord-015021-pol2qm74 6396 21 with with IN cord-015021-pol2qm74 6396 22 multiple multiple JJ cord-015021-pol2qm74 6396 23 injuries injury NNS cord-015021-pol2qm74 6396 24 regarding regard VBG cord-015021-pol2qm74 6396 25 blood blood NN cord-015021-pol2qm74 6396 26 levels level NNS cord-015021-pol2qm74 6396 27 of of IN cord-015021-pol2qm74 6396 28 antithrombin antithrombin NN cord-015021-pol2qm74 6396 29 III III NNP cord-015021-pol2qm74 6396 30 and and CC cord-015021-pol2qm74 6396 31 undesired undesired JJ cord-015021-pol2qm74 6396 32 side side NN cord-015021-pol2qm74 6396 33 effcts effct NNS cord-015021-pol2qm74 6396 34 and and CC cord-015021-pol2qm74 6396 35 to to TO cord-015021-pol2qm74 6396 36 analyse analyse VB cord-015021-pol2qm74 6396 37 effects effect NNS cord-015021-pol2qm74 6396 38 of of IN cord-015021-pol2qm74 6396 39 the the DT cord-015021-pol2qm74 6396 40 initibitortherapy initibitortherapy NN cord-015021-pol2qm74 6396 41 on on IN cord-015021-pol2qm74 6396 42 the the DT cord-015021-pol2qm74 6396 43 systemic systemic JJ cord-015021-pol2qm74 6396 44 inflammatory inflammatory JJ cord-015021-pol2qm74 6396 45 response response NN cord-015021-pol2qm74 6396 46 . . . cord-015021-pol2qm74 6397 1 Patients patient NNS cord-015021-pol2qm74 6397 2 and and CC cord-015021-pol2qm74 6397 3 methods method NNS cord-015021-pol2qm74 6397 4 : : : cord-015021-pol2qm74 6397 5 20 20 CD cord-015021-pol2qm74 6397 6 patients patient NNS cord-015021-pol2qm74 6397 7 with with IN cord-015021-pol2qm74 6397 8 an an DT cord-015021-pol2qm74 6397 9 ISS ISS NNP cord-015021-pol2qm74 6397 10 nf nf NN cord-015021-pol2qm74 6397 11 more more JJR cord-015021-pol2qm74 6397 12 than than IN cord-015021-pol2qm74 6397 13 28 28 CD cord-015021-pol2qm74 6397 14 points point NNS cord-015021-pol2qm74 6397 15 who who WP cord-015021-pol2qm74 6397 16 could could MD cord-015021-pol2qm74 6397 17 be be VB cord-015021-pol2qm74 6397 18 treated treat VBN cord-015021-pol2qm74 6397 19 with with IN cord-015021-pol2qm74 6397 20 AT AT NNP cord-015021-pol2qm74 6397 21 III III NNP cord-015021-pol2qm74 6397 22 administration administration NN cord-015021-pol2qm74 6397 23 within within IN cord-015021-pol2qm74 6397 24 180 180 CD cord-015021-pol2qm74 6397 25 rain rain NN cord-015021-pol2qm74 6397 26 after after IN cord-015021-pol2qm74 6397 27 trauma trauma NN cord-015021-pol2qm74 6397 28 were be VBD cord-015021-pol2qm74 6397 29 randomized randomize VBN cord-015021-pol2qm74 6397 30 to to TO cord-015021-pol2qm74 6397 31 receive receive VB cord-015021-pol2qm74 6397 32 either either CC cord-015021-pol2qm74 6397 33 AT AT NNP cord-015021-pol2qm74 6397 34 III iii CD cord-015021-pol2qm74 6397 35 or or CC cord-015021-pol2qm74 6397 36 placebo placebo NN cord-015021-pol2qm74 6397 37 . . . cord-015021-pol2qm74 6398 1 AT at IN cord-015021-pol2qm74 6398 2 III III NNP cord-015021-pol2qm74 6398 3 was be VBD cord-015021-pol2qm74 6398 4 given give VBN cord-015021-pol2qm74 6398 5 to to TO cord-015021-pol2qm74 6398 6 reach reach VB cord-015021-pol2qm74 6398 7 an an DT cord-015021-pol2qm74 6398 8 antithrombin antithrombin NN cord-015021-pol2qm74 6398 9 III iii CD cord-015021-pol2qm74 6398 10 inhibitory inhibitory JJ cord-015021-pol2qm74 6398 11 capacity capacity NN cord-015021-pol2qm74 6398 12 in in IN cord-015021-pol2qm74 6398 13 plasma plasma NN cord-015021-pol2qm74 6398 14 of of IN cord-015021-pol2qm74 6398 15 140 140 CD cord-015021-pol2qm74 6398 16 % % NN cord-015021-pol2qm74 6398 17 by by IN cord-015021-pol2qm74 6398 18 using use VBG cord-015021-pol2qm74 6398 19 the the DT cord-015021-pol2qm74 6398 20 following follow VBG cord-015021-pol2qm74 6398 21 calculation calculation NN cord-015021-pol2qm74 6398 22 : : : cord-015021-pol2qm74 6398 23 AT at IN cord-015021-pol2qm74 6398 24 III III NNP cord-015021-pol2qm74 6398 25 to to TO cord-015021-pol2qm74 6398 26 administer administer VB cord-015021-pol2qm74 6398 27 = = NFP cord-015021-pol2qm74 6398 28 ( ( -LRB- cord-015021-pol2qm74 6398 29 140 140 CD cord-015021-pol2qm74 6398 30 % % NN cord-015021-pol2qm74 6398 31 -AT -AT HYPH cord-015021-pol2qm74 6398 32 III iii CD cord-015021-pol2qm74 6398 33 measured measure VBN cord-015021-pol2qm74 6398 34 ) ) -RRB- cord-015021-pol2qm74 6399 1 x x SYM cord-015021-pol2qm74 6399 2 body body NN cord-015021-pol2qm74 6399 3 weight weight NN cord-015021-pol2qm74 6399 4 . . . cord-015021-pol2qm74 6400 1 AT at IN cord-015021-pol2qm74 6400 2 III III NNP cord-015021-pol2qm74 6400 3 was be VBD cord-015021-pol2qm74 6400 4 given give VBN cord-015021-pol2qm74 6400 5 every every DT cord-015021-pol2qm74 6400 6 six six CD cord-015021-pol2qm74 6400 7 hours hour NNS cord-015021-pol2qm74 6400 8 for for IN cord-015021-pol2qm74 6400 9 a a DT cord-015021-pol2qm74 6400 10 period period NN cord-015021-pol2qm74 6400 11 nf48 nf48 RB cord-015021-pol2qm74 6400 12 hours hour NNS cord-015021-pol2qm74 6400 13 and and CC cord-015021-pol2qm74 6400 14 on on IN cord-015021-pol2qm74 6400 15 the the DT cord-015021-pol2qm74 6400 16 4th 4th JJ cord-015021-pol2qm74 6400 17 day day NN cord-015021-pol2qm74 6400 18 . . . cord-015021-pol2qm74 6401 1 Patients patient NNS cord-015021-pol2qm74 6401 2 were be VBD cord-015021-pol2qm74 6401 3 followed follow VBN cord-015021-pol2qm74 6401 4 up up RP cord-015021-pol2qm74 6401 5 throughout throughout IN cord-015021-pol2qm74 6401 6 their -PRON- PRP$ cord-015021-pol2qm74 6401 7 stay stay NN cord-015021-pol2qm74 6401 8 in in IN cord-015021-pol2qm74 6401 9 the the DT cord-015021-pol2qm74 6401 10 ICU ICU NNP cord-015021-pol2qm74 6402 1 but but CC cord-015021-pol2qm74 6402 2 at at RB cord-015021-pol2qm74 6402 3 least least RBS cord-015021-pol2qm74 6402 4 14 14 CD cord-015021-pol2qm74 6402 5 days day NNS cord-015021-pol2qm74 6402 6 . . . cord-015021-pol2qm74 6403 1 In in IN cord-015021-pol2qm74 6403 2 this this DT cord-015021-pol2qm74 6403 3 abstract abstract JJ cord-015021-pol2qm74 6403 4 the the DT cord-015021-pol2qm74 6403 5 data datum NNS cord-015021-pol2qm74 6403 6 of of IN cord-015021-pol2qm74 6403 7 the the DT cord-015021-pol2qm74 6403 8 first first JJ cord-015021-pol2qm74 6403 9 10 10 CD cord-015021-pol2qm74 6403 10 patients patient NNS cord-015021-pol2qm74 6403 11 are be VBP cord-015021-pol2qm74 6403 12 included include VBN cord-015021-pol2qm74 6403 13 . . . cord-015021-pol2qm74 6404 1 Results result NNS cord-015021-pol2qm74 6404 2 : : : cord-015021-pol2qm74 6405 1 The the DT cord-015021-pol2qm74 6405 2 patients patient NNS cord-015021-pol2qm74 6405 3 ' ' POS cord-015021-pol2qm74 6405 4 median median JJ cord-015021-pol2qm74 6405 5 injury injury NN cord-015021-pol2qm74 6405 6 severity severity NN cord-015021-pol2qm74 6405 7 score score NN cord-015021-pol2qm74 6405 8 was be VBD cord-015021-pol2qm74 6405 9 41 41 CD cord-015021-pol2qm74 6405 10 points point NNS cord-015021-pol2qm74 6405 11 with with IN cord-015021-pol2qm74 6405 12 a a DT cord-015021-pol2qm74 6405 13 median median JJ cord-015021-pol2qm74 6405 14 age age NN cord-015021-pol2qm74 6405 15 of of IN cord-015021-pol2qm74 6405 16 42 42 CD cord-015021-pol2qm74 6405 17 years year NNS cord-015021-pol2qm74 6405 18 . . . cord-015021-pol2qm74 6406 1 The the DT cord-015021-pol2qm74 6406 2 patients patient NNS cord-015021-pol2qm74 6406 3 were be VBD cord-015021-pol2qm74 6406 4 equally equally RB cord-015021-pol2qm74 6406 5 distributed distribute VBN cord-015021-pol2qm74 6406 6 between between IN cord-015021-pol2qm74 6406 7 verum verum NN cord-015021-pol2qm74 6406 8 and and CC cord-015021-pol2qm74 6406 9 placebo placebo NN cord-015021-pol2qm74 6406 10 groups group NNS cord-015021-pol2qm74 6406 11 with with IN cord-015021-pol2qm74 6406 12 respact respact NN cord-015021-pol2qm74 6406 13 to to IN cord-015021-pol2qm74 6406 14 age age NN cord-015021-pol2qm74 6406 15 , , , cord-015021-pol2qm74 6406 16 ISS ISS NNP cord-015021-pol2qm74 6406 17 , , , cord-015021-pol2qm74 6406 18 prehospital prehospital JJ cord-015021-pol2qm74 6406 19 treatment treatment NN cord-015021-pol2qm74 6406 20 , , , cord-015021-pol2qm74 6406 21 blood blood NN cord-015021-pol2qm74 6406 22 pressure pressure NN cord-015021-pol2qm74 6406 23 , , , cord-015021-pol2qm74 6406 24 hemoglobin hemoglobin NN cord-015021-pol2qm74 6406 25 and and CC cord-015021-pol2qm74 6406 26 AT at IN cord-015021-pol2qm74 6406 27 nMevel nMevel NNP cord-015021-pol2qm74 6406 28 on on IN cord-015021-pol2qm74 6406 29 admission admission NN cord-015021-pol2qm74 6406 30 , , , cord-015021-pol2qm74 6406 31 and and CC cord-015021-pol2qm74 6406 32 time time NN cord-015021-pol2qm74 6406 33 from from IN cord-015021-pol2qm74 6406 34 the the DT cord-015021-pol2qm74 6406 35 accident accident NN cord-015021-pol2qm74 6406 36 until until IN cord-015021-pol2qm74 6406 37 the the DT cord-015021-pol2qm74 6406 38 test test NN cord-015021-pol2qm74 6406 39 solution solution NN cord-015021-pol2qm74 6406 40 was be VBD cord-015021-pol2qm74 6406 41 given give VBN cord-015021-pol2qm74 6406 42 . . . cord-015021-pol2qm74 6407 1 The the DT cord-015021-pol2qm74 6407 2 patients patient NNS cord-015021-pol2qm74 6407 3 of of IN cord-015021-pol2qm74 6407 4 the the DT cord-015021-pol2qm74 6407 5 AT AT NNP cord-015021-pol2qm74 6407 6 III iii CD cord-015021-pol2qm74 6407 7 group group NN cord-015021-pol2qm74 6407 8 received receive VBD cord-015021-pol2qm74 6407 9 18,100 18,100 CD cord-015021-pol2qm74 6407 10 units unit NNS cord-015021-pol2qm74 6407 11 of of IN cord-015021-pol2qm74 6407 12 the the DT cord-015021-pol2qm74 6407 13 inhibitor inhibitor NN cord-015021-pol2qm74 6407 14 on on IN cord-015021-pol2qm74 6407 15 average average NN cord-015021-pol2qm74 6407 16 during during IN cord-015021-pol2qm74 6407 17 the the DT cord-015021-pol2qm74 6407 18 first first JJ cord-015021-pol2qm74 6407 19 4 4 CD cord-015021-pol2qm74 6407 20 days day NNS cord-015021-pol2qm74 6407 21 . . . cord-015021-pol2qm74 6408 1 With with IN cord-015021-pol2qm74 6408 2 our -PRON- PRP$ cord-015021-pol2qm74 6408 3 regimen regimen NN cord-015021-pol2qm74 6408 4 , , , cord-015021-pol2qm74 6408 5 the the DT cord-015021-pol2qm74 6408 6 AT AT NNP cord-015021-pol2qm74 6408 7 III iii CD cord-015021-pol2qm74 6408 8 levels level NNS cord-015021-pol2qm74 6408 9 could could MD cord-015021-pol2qm74 6408 10 be be VB cord-015021-pol2qm74 6408 11 kept keep VBN cord-015021-pol2qm74 6408 12 between between IN cord-015021-pol2qm74 6408 13 125 125 CD cord-015021-pol2qm74 6408 14 % % NN cord-015021-pol2qm74 6408 15 and and CC cord-015021-pol2qm74 6408 16 140 140 CD cord-015021-pol2qm74 6408 17 % % NN cord-015021-pol2qm74 6408 18 of of IN cord-015021-pol2qm74 6408 19 normal normal JJ cord-015021-pol2qm74 6408 20 , , , cord-015021-pol2qm74 6408 21 whereas whereas IN cord-015021-pol2qm74 6408 22 control control NN cord-015021-pol2qm74 6408 23 patients patient NNS cord-015021-pol2qm74 6408 24 an an DT cord-015021-pol2qm74 6408 25 AT AT NNP cord-015021-pol2qm74 6408 26 HI HI NNP cord-015021-pol2qm74 6408 27 concentration concentration NN cord-015021-pol2qm74 6408 28 of of IN cord-015021-pol2qm74 6408 29 40 40 CD cord-015021-pol2qm74 6408 30 % % NN cord-015021-pol2qm74 6408 31 to to TO cord-015021-pol2qm74 6408 32 60 60 CD cord-015021-pol2qm74 6408 33 % % NN cord-015021-pol2qm74 6408 34 was be VBD cord-015021-pol2qm74 6408 35 observed observe VBN cord-015021-pol2qm74 6408 36 . . . cord-015021-pol2qm74 6409 1 Patients patient NNS cord-015021-pol2qm74 6409 2 with with IN cord-015021-pol2qm74 6409 3 AT AT NNP cord-015021-pol2qm74 6409 4 nI nI NNP cord-015021-pol2qm74 6409 5 treatment treatment NN cord-015021-pol2qm74 6409 6 required require VBD cord-015021-pol2qm74 6409 7 less less JJR cord-015021-pol2qm74 6409 8 red red JJ cord-015021-pol2qm74 6409 9 blood blood NN cord-015021-pol2qm74 6409 10 cells cell NNS cord-015021-pol2qm74 6409 11 bur bur NN cord-015021-pol2qm74 6409 12 received receive VBD cord-015021-pol2qm74 6409 13 the the DT cord-015021-pol2qm74 6409 14 same same JJ cord-015021-pol2qm74 6409 15 amount amount NN cord-015021-pol2qm74 6409 16 of of IN cord-015021-pol2qm74 6409 17 FFP ffp NN cord-015021-pol2qm74 6409 18 and and CC cord-015021-pol2qm74 6409 19 fluids fluid NNS cord-015021-pol2qm74 6409 20 . . . cord-015021-pol2qm74 6410 1 There there EX cord-015021-pol2qm74 6410 2 were be VBD cord-015021-pol2qm74 6410 3 no no DT cord-015021-pol2qm74 6410 4 differences difference NNS cord-015021-pol2qm74 6410 5 with with IN cord-015021-pol2qm74 6410 6 respect respect NN cord-015021-pol2qm74 6410 7 to to IN cord-015021-pol2qm74 6410 8 platelet platelet NN cord-015021-pol2qm74 6410 9 count count NN cord-015021-pol2qm74 6410 10 , , , cord-015021-pol2qm74 6410 11 partial partial JJ cord-015021-pol2qm74 6410 12 thromboplastin thromboplastin NNP cord-015021-pol2qm74 6410 13 time time NN cord-015021-pol2qm74 6410 14 , , , cord-015021-pol2qm74 6410 15 l l NNP cord-015021-pol2qm74 6410 16 ~ ~ NFP cord-015021-pol2qm74 6410 17 rothrombin rothrombin JJ cord-015021-pol2qm74 6410 18 time time NN cord-015021-pol2qm74 6410 19 and and CC cord-015021-pol2qm74 6410 20 prothrombim prothrombim NNP cord-015021-pol2qm74 6410 21 . . . cord-015021-pol2qm74 6411 1 We -PRON- PRP cord-015021-pol2qm74 6411 2 did do VBD cord-015021-pol2qm74 6411 3 not not RB cord-015021-pol2qm74 6411 4 observe observe VB cord-015021-pol2qm74 6411 5 bleeding bleed VBG cord-015021-pol2qm74 6411 6 disorders disorder NNS cord-015021-pol2qm74 6411 7 or or CC cord-015021-pol2qm74 6411 8 any any DT cord-015021-pol2qm74 6411 9 other other JJ cord-015021-pol2qm74 6411 10 side side NN cord-015021-pol2qm74 6411 11 effect effect NN cord-015021-pol2qm74 6411 12 with with IN cord-015021-pol2qm74 6411 13 peak peak JJ cord-015021-pol2qm74 6411 14 concetrations concetration NNS cord-015021-pol2qm74 6411 15 of of IN cord-015021-pol2qm74 6411 16 up up IN cord-015021-pol2qm74 6411 17 to to TO cord-015021-pol2qm74 6411 18 206 206 CD cord-015021-pol2qm74 6411 19 % % NN cord-015021-pol2qm74 6411 20 of of IN cord-015021-pol2qm74 6411 21 normal normal JJ cord-015021-pol2qm74 6411 22 . . . cord-015021-pol2qm74 6412 1 White white JJ cord-015021-pol2qm74 6412 2 blood blood NN cord-015021-pol2qm74 6412 3 count count NN cord-015021-pol2qm74 6412 4 , , , cord-015021-pol2qm74 6412 5 PMN pmn NN cord-015021-pol2qm74 6412 6 -- -- : cord-015021-pol2qm74 6412 7 elastase elastase NN cord-015021-pol2qm74 6412 8 , , , cord-015021-pol2qm74 6412 9 Interleukin Interleukin NNP cord-015021-pol2qm74 6412 10 6 6 CD cord-015021-pol2qm74 6412 11 and and CC cord-015021-pol2qm74 6412 12 8 8 CD cord-015021-pol2qm74 6412 13 and and CC cord-015021-pol2qm74 6412 14 C c NN cord-015021-pol2qm74 6412 15 - - HYPH cord-015021-pol2qm74 6412 16 reactive reactive JJ cord-015021-pol2qm74 6412 17 protein protein NN cord-015021-pol2qm74 6412 18 tended tend VBD cord-015021-pol2qm74 6412 19 to to TO cord-015021-pol2qm74 6412 20 be be VB cord-015021-pol2qm74 6412 21 lower low JJR cord-015021-pol2qm74 6412 22 in in IN cord-015021-pol2qm74 6412 23 the the DT cord-015021-pol2qm74 6412 24 AT AT NNP cord-015021-pol2qm74 6412 25 III iii CD cord-015021-pol2qm74 6412 26 group group NN cord-015021-pol2qm74 6412 27 . . . cord-015021-pol2qm74 6413 1 There there EX cord-015021-pol2qm74 6413 2 were be VBD cord-015021-pol2qm74 6413 3 no no DT cord-015021-pol2qm74 6413 4 differences difference NNS cord-015021-pol2qm74 6413 5 with with IN cord-015021-pol2qm74 6413 6 respect respect NN cord-015021-pol2qm74 6413 7 to to IN cord-015021-pol2qm74 6413 8 renal renal JJ cord-015021-pol2qm74 6413 9 and and CC cord-015021-pol2qm74 6413 10 hepatic hepatic JJ cord-015021-pol2qm74 6413 11 function function NN cord-015021-pol2qm74 6413 12 parameters parameter NNS cord-015021-pol2qm74 6413 13 but but CC cord-015021-pol2qm74 6413 14 the the DT cord-015021-pol2qm74 6413 15 duration duration NN cord-015021-pol2qm74 6413 16 od od NNP cord-015021-pol2qm74 6413 17 mechanical mechanical JJ cord-015021-pol2qm74 6413 18 ventilation ventilation NN cord-015021-pol2qm74 6413 19 was be VBD cord-015021-pol2qm74 6413 20 shorter short JJR cord-015021-pol2qm74 6413 21 in in IN cord-015021-pol2qm74 6413 22 the the DT cord-015021-pol2qm74 6413 23 AT AT NNP cord-015021-pol2qm74 6413 24 II1 II1 NNP cord-015021-pol2qm74 6413 25 group group NN cord-015021-pol2qm74 6413 26 ( ( -LRB- cord-015021-pol2qm74 6413 27 8.5 8.5 CD cord-015021-pol2qm74 6413 28 vs. vs. NN cord-015021-pol2qm74 6413 29 15.8 15.8 CD cord-015021-pol2qm74 6413 30 days day NNS cord-015021-pol2qm74 6413 31 ) ) -RRB- cord-015021-pol2qm74 6414 1 Conclusions conclusion NNS cord-015021-pol2qm74 6414 2 : : : cord-015021-pol2qm74 6415 1 We -PRON- PRP cord-015021-pol2qm74 6415 2 conclude conclude VBP cord-015021-pol2qm74 6415 3 that that IN cord-015021-pol2qm74 6415 4 our -PRON- PRP$ cord-015021-pol2qm74 6415 5 treatment treatment NN cord-015021-pol2qm74 6415 6 protocol protocol NN cord-015021-pol2qm74 6415 7 ( ( -LRB- cord-015021-pol2qm74 6415 8 a a LS cord-015021-pol2qm74 6415 9 ) ) -RRB- cord-015021-pol2qm74 6415 10 was be VBD cord-015021-pol2qm74 6415 11 able able JJ cord-015021-pol2qm74 6415 12 to to TO cord-015021-pol2qm74 6415 13 restore restore VB cord-015021-pol2qm74 6415 14 AT at IN cord-015021-pol2qm74 6415 15 IIl IIl NNS cord-015021-pol2qm74 6415 16 levels level NNS cord-015021-pol2qm74 6415 17 to to IN cord-015021-pol2qm74 6415 18 the the DT cord-015021-pol2qm74 6415 19 desired desire VBN cord-015021-pol2qm74 6415 20 range range NN cord-015021-pol2qm74 6415 21 of of IN cord-015021-pol2qm74 6415 22 140 140 CD cord-015021-pol2qm74 6415 23 % % NN cord-015021-pol2qm74 6415 24 , , , cord-015021-pol2qm74 6415 25 ( ( -LRB- cord-015021-pol2qm74 6415 26 b b NN cord-015021-pol2qm74 6415 27 ) ) -RRB- cord-015021-pol2qm74 6415 28 did do VBD cord-015021-pol2qm74 6415 29 not not RB cord-015021-pol2qm74 6415 30 lead lead VB cord-015021-pol2qm74 6415 31 to to IN cord-015021-pol2qm74 6415 32 coagulation coagulation NN cord-015021-pol2qm74 6415 33 disorders disorder NNS cord-015021-pol2qm74 6415 34 , , , cord-015021-pol2qm74 6415 35 ( ( -LRB- cord-015021-pol2qm74 6415 36 c c NN cord-015021-pol2qm74 6415 37 ) ) -RRB- cord-015021-pol2qm74 6415 38 did do VBD cord-015021-pol2qm74 6415 39 not not RB cord-015021-pol2qm74 6415 40 increase increase VB cord-015021-pol2qm74 6415 41 transfusion transfusion NN cord-015021-pol2qm74 6415 42 requirements requirement NNS cord-015021-pol2qm74 6415 43 , , , cord-015021-pol2qm74 6415 44 ( ( -LRB- cord-015021-pol2qm74 6415 45 d d LS cord-015021-pol2qm74 6415 46 ) ) -RRB- cord-015021-pol2qm74 6415 47 did do VBD cord-015021-pol2qm74 6415 48 not not RB cord-015021-pol2qm74 6415 49 reveal reveal VB cord-015021-pol2qm74 6415 50 other other JJ cord-015021-pol2qm74 6415 51 undesired undesired JJ cord-015021-pol2qm74 6415 52 side side NN cord-015021-pol2qm74 6415 53 effects effect NNS cord-015021-pol2qm74 6415 54 , , , cord-015021-pol2qm74 6415 55 and and CC cord-015021-pol2qm74 6415 56 ( ( -LRB- cord-015021-pol2qm74 6415 57 e e NN cord-015021-pol2qm74 6415 58 ) ) -RRB- cord-015021-pol2qm74 6415 59 showed show VBD cord-015021-pol2qm74 6415 60 a a DT cord-015021-pol2qm74 6415 61 tendency tendency NN cord-015021-pol2qm74 6415 62 towards towards IN cord-015021-pol2qm74 6415 63 reduced reduce VBN cord-015021-pol2qm74 6415 64 posttranmatic posttranmatic JJ cord-015021-pol2qm74 6415 65 inflammation inflammation NN cord-015021-pol2qm74 6415 66 and and CC cord-015021-pol2qm74 6415 67 mechanical mechanical JJ cord-015021-pol2qm74 6415 68 ventilation ventilation NN cord-015021-pol2qm74 6415 69 requirements requirement NNS cord-015021-pol2qm74 6415 70 Department Department NNP cord-015021-pol2qm74 6415 71 of of IN cord-015021-pol2qm74 6415 72 Trauma Trauma NNP cord-015021-pol2qm74 6415 73 Surgery Surgery NNP cord-015021-pol2qm74 6415 74 , , , cord-015021-pol2qm74 6415 75 45122 45122 CD cord-015021-pol2qm74 6415 76 Essen Essen NNP cord-015021-pol2qm74 6415 77 , , , cord-015021-pol2qm74 6415 78 Germany Germany NNP cord-015021-pol2qm74 6415 79 Antithrombin Antithrombin NNP cord-015021-pol2qm74 6415 80 - - HYPH cord-015021-pol2qm74 6415 81 lll lll NNP cord-015021-pol2qm74 6415 82 ( ( -LRB- cord-015021-pol2qm74 6415 83 AT AT NNP cord-015021-pol2qm74 6415 84 - - HYPH cord-015021-pol2qm74 6415 85 Ill Ill NNP cord-015021-pol2qm74 6415 86 ) ) -RRB- cord-015021-pol2qm74 6415 87 acts act VBZ cord-015021-pol2qm74 6415 88 as as IN cord-015021-pol2qm74 6415 89 an an DT cord-015021-pol2qm74 6415 90 inhibitor inhibitor NN cord-015021-pol2qm74 6415 91 of of IN cord-015021-pol2qm74 6415 92 thrombin thrombin NN cord-015021-pol2qm74 6415 93 , , , cord-015021-pol2qm74 6415 94 further further JJ cord-015021-pol2qm74 6415 95 proteases protease NNS cord-015021-pol2qm74 6415 96 and and CC cord-015021-pol2qm74 6415 97 the the DT cord-015021-pol2qm74 6415 98 alternative alternative JJ cord-015021-pol2qm74 6415 99 pathway pathway NN cord-015021-pol2qm74 6415 100 of of IN cord-015021-pol2qm74 6415 101 the the DT cord-015021-pol2qm74 6415 102 complement complement JJ cord-015021-pol2qm74 6415 103 system system NN cord-015021-pol2qm74 6415 104 . . . cord-015021-pol2qm74 6416 1 Inhibiting inhibit VBG cord-015021-pol2qm74 6416 2 thrombin thrombin NN cord-015021-pol2qm74 6416 3 , , , cord-015021-pol2qm74 6416 4 AT AT NNP cord-015021-pol2qm74 6416 5 - - HYPH cord-015021-pol2qm74 6416 6 Ill Ill NNP cord-015021-pol2qm74 6416 7 works work VBZ cord-015021-pol2qm74 6416 8 as as IN cord-015021-pol2qm74 6416 9 a a DT cord-015021-pol2qm74 6416 10 functional functional JJ cord-015021-pol2qm74 6416 11 antagonist antagonist NN cord-015021-pol2qm74 6416 12 of of IN cord-015021-pol2qm74 6417 1 PAF~ PAF~ NNP cord-015021-pol2qm74 6417 2 Therefore therefore RB cord-015021-pol2qm74 6417 3 , , , cord-015021-pol2qm74 6417 4 in in IN cord-015021-pol2qm74 6417 5 state state NN cord-015021-pol2qm74 6417 6 of of IN cord-015021-pol2qm74 6417 7 hypevolemic hypevolemic NN cord-015021-pol2qm74 6417 8 - - HYPH cord-015021-pol2qm74 6417 9 traumatic traumatic JJ cord-015021-pol2qm74 6417 10 shock shock NN cord-015021-pol2qm74 6417 11 , , , cord-015021-pol2qm74 6417 12 continuous continuous JJ cord-015021-pol2qm74 6417 13 supranormal supranormal JJ cord-015021-pol2qm74 6417 14 serum serum NN cord-015021-pol2qm74 6417 15 -and -and CC cord-015021-pol2qm74 6417 16 tissue tissue NN cord-015021-pol2qm74 6417 17 -concentrations -concentration NNS cord-015021-pol2qm74 6417 18 of of IN cord-015021-pol2qm74 6417 19 AT AT NNP cord-015021-pol2qm74 6417 20 - - HYPH cord-015021-pol2qm74 6417 21 Ill Ill NNP cord-015021-pol2qm74 6417 22 may may MD cord-015021-pol2qm74 6417 23 be be VB cord-015021-pol2qm74 6417 24 efficient efficient JJ cord-015021-pol2qm74 6417 25 to to TO cord-015021-pol2qm74 6417 26 reduce reduce VB cord-015021-pol2qm74 6417 27 the the DT cord-015021-pol2qm74 6417 28 local local JJ cord-015021-pol2qm74 6417 29 posttraumatic posttraumatic JJ cord-015021-pol2qm74 6417 30 reactions reaction NNS cord-015021-pol2qm74 6417 31 resulting result VBG cord-015021-pol2qm74 6417 32 from from IN cord-015021-pol2qm74 6417 33 complement complement NN cord-015021-pol2qm74 6417 34 and and CC cord-015021-pol2qm74 6417 35 PMN pmn NN cord-015021-pol2qm74 6417 36 - - HYPH cord-015021-pol2qm74 6417 37 activation activation NN cord-015021-pol2qm74 6417 38 . . . cord-015021-pol2qm74 6418 1 20 20 CD cord-015021-pol2qm74 6418 2 patients patient NNS cord-015021-pol2qm74 6418 3 with with IN cord-015021-pol2qm74 6418 4 severe severe JJ cord-015021-pol2qm74 6418 5 multiple multiple JJ cord-015021-pol2qm74 6418 6 trauma trauma NN cord-015021-pol2qm74 6418 7 ( ( -LRB- cord-015021-pol2qm74 6418 8 7 7 CD cord-015021-pol2qm74 6418 9 treatment treatment NN cord-015021-pol2qm74 6418 10 [ [ -LRB- cord-015021-pol2qm74 6418 11 AT AT NNP cord-015021-pol2qm74 6418 12 - - HYPH cord-015021-pol2qm74 6418 13 Ill Ill NNP cord-015021-pol2qm74 6418 14 ] ] -RRB- cord-015021-pol2qm74 6419 1 --13 --13 NNP cord-015021-pol2qm74 6419 2 controls control VBZ cord-015021-pol2qm74 6419 3 [ [ -LRB- cord-015021-pol2qm74 6419 4 C C NNP cord-015021-pol2qm74 6419 5 ] ] -RRB- cord-015021-pol2qm74 6419 6 ) ) -RRB- cord-015021-pol2qm74 6419 7 were be VBD cord-015021-pol2qm74 6419 8 investigated investigate VBN cord-015021-pol2qm74 6419 9 . . . cord-015021-pol2qm74 6420 1 Study study NN cord-015021-pol2qm74 6420 2 cdteda cdteda NN cord-015021-pol2qm74 6420 3 were be VBD cord-015021-pol2qm74 6420 4 age age NN cord-015021-pol2qm74 6421 1 > > XX cord-015021-pol2qm74 6422 1 16 16 CD cord-015021-pol2qm74 6422 2 and and CC cord-015021-pol2qm74 6422 3 < < XX cord-015021-pol2qm74 6422 4 65 65 CD cord-015021-pol2qm74 6422 5 years year NNS cord-015021-pol2qm74 6422 6 , , , cord-015021-pol2qm74 6422 7 injury injury NN cord-015021-pol2qm74 6422 8 severity severity NN cord-015021-pol2qm74 6422 9 ( ( -LRB- cord-015021-pol2qm74 6422 10 ISS ISS NNP cord-015021-pol2qm74 6422 11 ) ) -RRB- cord-015021-pol2qm74 6422 12 > > XX cord-015021-pol2qm74 6423 1 30 30 CD cord-015021-pol2qm74 6423 2 points point NNS cord-015021-pol2qm74 6423 3 and and CC cord-015021-pol2qm74 6423 4 Glasgow Glasgow NNP cord-015021-pol2qm74 6423 5 - - HYPH cord-015021-pol2qm74 6423 6 Coma Coma NNP cord-015021-pol2qm74 6423 7 - - HYPH cord-015021-pol2qm74 6423 8 Scale Scale NNP cord-015021-pol2qm74 6423 9 > > SYM cord-015021-pol2qm74 6423 10 8 8 CD cord-015021-pol2qm74 6423 11 points point NNS cord-015021-pol2qm74 6423 12 ; ; : cord-015021-pol2qm74 6423 13 Randomization randomization NN cord-015021-pol2qm74 6423 14 and and CC cord-015021-pol2qm74 6423 15 treatment treatment NN cord-015021-pol2qm74 6423 16 has have VBZ cord-015021-pol2qm74 6423 17 to to TO cord-015021-pol2qm74 6423 18 be be VB cord-015021-pol2qm74 6423 19 started start VBN cord-015021-pol2qm74 6423 20 within within IN cord-015021-pol2qm74 6423 21 6 6 CD cord-015021-pol2qm74 6423 22 hours hour NNS cord-015021-pol2qm74 6423 23 after after IN cord-015021-pol2qm74 6423 24 trauma trauma NN cord-015021-pol2qm74 6423 25 . . . cord-015021-pol2qm74 6424 1 Permission permission NN cord-015021-pol2qm74 6424 2 for for IN cord-015021-pol2qm74 6424 3 the the DT cord-015021-pol2qm74 6424 4 clinical clinical JJ cord-015021-pol2qm74 6424 5 study study NN cord-015021-pol2qm74 6424 6 was be VBD cord-015021-pol2qm74 6424 7 given give VBN cord-015021-pol2qm74 6424 8 by by IN cord-015021-pol2qm74 6424 9 the the DT cord-015021-pol2qm74 6424 10 local local JJ cord-015021-pol2qm74 6424 11 ethic ethic NNP cord-015021-pol2qm74 6424 12 committee committee NN cord-015021-pol2qm74 6424 13 . . . cord-015021-pol2qm74 6425 1 Bradykinin Bradykinin NNP cord-015021-pol2qm74 6425 2 ( ( -LRB- cord-015021-pol2qm74 6425 3 BK BK NNP cord-015021-pol2qm74 6425 4 ) ) -RRB- cord-015021-pol2qm74 6425 5 and and CC cord-015021-pol2qm74 6425 6 related relate VBN cord-015021-pol2qm74 6425 7 kinins kinin NNS cord-015021-pol2qm74 6425 8 are be VBP cord-015021-pol2qm74 6425 9 potent potent JJ cord-015021-pol2qm74 6425 10 inflammatory inflammatory JJ cord-015021-pol2qm74 6425 11 peptides peptide NNS cord-015021-pol2qm74 6425 12 which which WDT cord-015021-pol2qm74 6425 13 possess possess VBP cord-015021-pol2qm74 6425 14 the the DT cord-015021-pol2qm74 6425 15 ability ability NN cord-015021-pol2qm74 6425 16 to to TO cord-015021-pol2qm74 6425 17 induce induce VB cord-015021-pol2qm74 6425 18 , , , cord-015021-pol2qm74 6425 19 vasodilation vasodilation NN cord-015021-pol2qm74 6425 20 , , , cord-015021-pol2qm74 6425 21 increased increase VBN cord-015021-pol2qm74 6425 22 vascular vascular JJ cord-015021-pol2qm74 6425 23 permeability permeability NN cord-015021-pol2qm74 6425 24 and and CC cord-015021-pol2qm74 6425 25 hyperalgesia hyperalgesia NN cord-015021-pol2qm74 6425 26 . . . cord-015021-pol2qm74 6426 1 CP-0127 CP-0127 NNP cord-015021-pol2qm74 6426 2 , , , cord-015021-pol2qm74 6426 3 a a DT cord-015021-pol2qm74 6426 4 novel novel NN cord-015021-pol2qm74 6426 5 homodimer homodimer VBN cord-015021-pol2qm74 6426 6 BK BK NNP cord-015021-pol2qm74 6426 7 antagonist antagonist NN cord-015021-pol2qm74 6426 8 has have VBZ cord-015021-pol2qm74 6426 9 previously previously RB cord-015021-pol2qm74 6426 10 been be VBN cord-015021-pol2qm74 6426 11 shown show VBN cord-015021-pol2qm74 6426 12 to to TO cord-015021-pol2qm74 6426 13 increase increase VB cord-015021-pol2qm74 6426 14 survival survival NN cord-015021-pol2qm74 6426 15 in in IN cord-015021-pol2qm74 6426 16 rat rat NN cord-015021-pol2qm74 6426 17 and and CC cord-015021-pol2qm74 6426 18 rabbit rabbit NN cord-015021-pol2qm74 6426 19 models model NNS cord-015021-pol2qm74 6426 20 of of IN cord-015021-pol2qm74 6426 21 lethal lethal JJ cord-015021-pol2qm74 6426 22 endotoxin endotoxin NN cord-015021-pol2qm74 6426 23 shock shock NN cord-015021-pol2qm74 6426 24 and and CC cord-015021-pol2qm74 6426 25 is be VBZ cord-015021-pol2qm74 6426 26 now now RB cord-015021-pol2qm74 6426 27 in in IN cord-015021-pol2qm74 6426 28 clinical clinical JJ cord-015021-pol2qm74 6426 29 trials trial NNS cord-015021-pol2qm74 6426 30 for for IN cord-015021-pol2qm74 6426 31 sepsis sepsis NN cord-015021-pol2qm74 6426 32 . . . cord-015021-pol2qm74 6427 1 We -PRON- PRP cord-015021-pol2qm74 6427 2 have have VBP cord-015021-pol2qm74 6427 3 now now RB cord-015021-pol2qm74 6427 4 evaluated evaluate VBN cord-015021-pol2qm74 6427 5 the the DT cord-015021-pol2qm74 6427 6 effect effect NN cord-015021-pol2qm74 6427 7 of of IN cord-015021-pol2qm74 6427 8 CP-0127 cp-0127 NN cord-015021-pol2qm74 6427 9 in in IN cord-015021-pol2qm74 6427 10 other other JJ cord-015021-pol2qm74 6427 11 models model NNS cord-015021-pol2qm74 6427 12 of of IN cord-015021-pol2qm74 6427 13 inflammation inflammation NN cord-015021-pol2qm74 6427 14 . . . cord-015021-pol2qm74 6428 1 Male male JJ cord-015021-pol2qm74 6428 2 rats rat NNS cord-015021-pol2qm74 6428 3 were be VBD cord-015021-pol2qm74 6428 4 precannulated precannulate VBN cord-015021-pol2qm74 6428 5 with with IN cord-015021-pol2qm74 6428 6 a a DT cord-015021-pol2qm74 6428 7 catheter catheter NN cord-015021-pol2qm74 6428 8 in in IN cord-015021-pol2qm74 6428 9 the the DT cord-015021-pol2qm74 6428 10 carotid carotid JJ cord-015021-pol2qm74 6428 11 artery artery NN cord-015021-pol2qm74 6428 12 . . . cord-015021-pol2qm74 6429 1 24h 24h NNP cord-015021-pol2qm74 6429 2 later later RB cord-015021-pol2qm74 6429 3 BK BK NNP cord-015021-pol2qm74 6429 4 was be VBD cord-015021-pol2qm74 6429 5 injected inject VBN cord-015021-pol2qm74 6429 6 ia ia NNP cord-015021-pol2qm74 6429 7 and and CC cord-015021-pol2qm74 6429 8 the the DT cord-015021-pol2qm74 6429 9 pain pain NN cord-015021-pol2qm74 6429 10 score score NN cord-015021-pol2qm74 6429 11 ranked rank VBD cord-015021-pol2qm74 6429 12 from from IN cord-015021-pol2qm74 6429 13 0 0 NFP cord-015021-pol2qm74 6429 14 ( ( -LRB- cord-015021-pol2qm74 6429 15 no no DT cord-015021-pol2qm74 6429 16 responses response NNS cord-015021-pol2qm74 6429 17 ) ) -RRB- cord-015021-pol2qm74 6429 18 to to IN cord-015021-pol2qm74 6429 19 5 5 CD cord-015021-pol2qm74 6429 20 ( ( -LRB- cord-015021-pol2qm74 6429 21 vocalization vocalization NN cord-015021-pol2qm74 6429 22 ) ) -RRB- cord-015021-pol2qm74 6429 23 . . . cord-015021-pol2qm74 6430 1 CP-0127 CP-0127 NNP cord-015021-pol2qm74 6430 2 at at IN cord-015021-pol2qm74 6430 3 3.6 3.6 CD cord-015021-pol2qm74 6430 4 umoles umole NNS cord-015021-pol2qm74 6430 5 / / SYM cord-015021-pol2qm74 6430 6 kg kg CC cord-015021-pol2qm74 6430 7 completely completely RB cord-015021-pol2qm74 6430 8 inhibited inhibit VBD cord-015021-pol2qm74 6430 9 the the DT cord-015021-pol2qm74 6430 10 pain pain NN cord-015021-pol2qm74 6430 11 responses response NNS cord-015021-pol2qm74 6430 12 for for IN cord-015021-pol2qm74 6430 13 a a DT cord-015021-pol2qm74 6430 14 period period NN cord-015021-pol2qm74 6430 15 of of IN cord-015021-pol2qm74 6430 16 2.5 2.5 CD cord-015021-pol2qm74 6430 17 -3h -3h NNS cord-015021-pol2qm74 6430 18 . . . cord-015021-pol2qm74 6431 1 CP-0127 CP-0127 NNP cord-015021-pol2qm74 6431 2 at at IN cord-015021-pol2qm74 6431 3 3.6 3.6 CD cord-015021-pol2qm74 6431 4 umoles umoles NNPS cord-015021-pol2qm74 6431 5 / / SYM cord-015021-pol2qm74 6431 6 kg kg NNP cord-015021-pol2qm74 6431 7 s.c s.c NNP cord-015021-pol2qm74 6431 8 . . NNP cord-015021-pol2qm74 6431 9 was be VBD cord-015021-pol2qm74 6431 10 also also RB cord-015021-pol2qm74 6431 11 found find VBN cord-015021-pol2qm74 6431 12 to to TO cord-015021-pol2qm74 6431 13 inhibit inhibit VB cord-015021-pol2qm74 6431 14 the the DT cord-015021-pol2qm74 6431 15 increase increase NN cord-015021-pol2qm74 6431 16 in in IN cord-015021-pol2qm74 6431 17 paw paw NN cord-015021-pol2qm74 6431 18 volume volume NN cord-015021-pol2qm74 6431 19 and and CC cord-015021-pol2qm74 6431 20 hyperalgesia hyperalgesia NN cord-015021-pol2qm74 6431 21 induced induce VBN cord-015021-pol2qm74 6431 22 in in IN cord-015021-pol2qm74 6431 23 rats rat NNS cord-015021-pol2qm74 6431 24 over over IN cord-015021-pol2qm74 6431 25 a a DT cord-015021-pol2qm74 6431 26 3 3 CD cord-015021-pol2qm74 6431 27 - - HYPH cord-015021-pol2qm74 6431 28 4h 4h CD cord-015021-pol2qm74 6431 29 period period NN cord-015021-pol2qm74 6431 30 by by IN cord-015021-pol2qm74 6431 31 an an DT cord-015021-pol2qm74 6431 32 intraplantar intraplantar JJ cord-015021-pol2qm74 6431 33 injection injection NN cord-015021-pol2qm74 6431 34 of of IN cord-015021-pol2qm74 6431 35 0.1 0.1 CD cord-015021-pol2qm74 6431 36 % % NN cord-015021-pol2qm74 6431 37 carrageenan carrageenan NN cord-015021-pol2qm74 6431 38 . . . cord-015021-pol2qm74 6432 1 The the DT cord-015021-pol2qm74 6432 2 abdominal abdominal JJ cord-015021-pol2qm74 6432 3 constriction constriction NN cord-015021-pol2qm74 6432 4 response response NN cord-015021-pol2qm74 6432 5 1o 1o CD cord-015021-pol2qm74 6433 1 an an DT cord-015021-pol2qm74 6433 2 intraperitoneal intraperitoneal JJ cord-015021-pol2qm74 6433 3 injection injection NN cord-015021-pol2qm74 6433 4 of of IN cord-015021-pol2qm74 6433 5 kaolin kaolin NN cord-015021-pol2qm74 6433 6 was be VBD cord-015021-pol2qm74 6433 7 inhibited inhibit VBN cord-015021-pol2qm74 6433 8 in in IN cord-015021-pol2qm74 6433 9 a a DT cord-015021-pol2qm74 6433 10 dose dose NN cord-015021-pol2qm74 6433 11 - - HYPH cord-015021-pol2qm74 6433 12 dependent dependent JJ cord-015021-pol2qm74 6433 13 manner manner NN cord-015021-pol2qm74 6433 14 by by IN cord-015021-pol2qm74 6433 15 CP-0127 CP-0127 NNP cord-015021-pol2qm74 6433 16 . . . cord-015021-pol2qm74 6434 1 When when WRB cord-015021-pol2qm74 6434 2 50 50 CD cord-015021-pol2qm74 6434 3 ul ul NN cord-015021-pol2qm74 6434 4 of of IN cord-015021-pol2qm74 6434 5 0.5 0.5 CD cord-015021-pol2qm74 6434 6 % % NN cord-015021-pol2qm74 6434 7 formalin formalin NN cord-015021-pol2qm74 6434 8 was be VBD cord-015021-pol2qm74 6434 9 injected inject VBN cord-015021-pol2qm74 6434 10 into into IN cord-015021-pol2qm74 6434 11 the the DT cord-015021-pol2qm74 6434 12 paw paw NN cord-015021-pol2qm74 6434 13 of of IN cord-015021-pol2qm74 6434 14 a a DT cord-015021-pol2qm74 6434 15 mouse mouse NN cord-015021-pol2qm74 6434 16 a a DT cord-015021-pol2qm74 6434 17 characteristic characteristic JJ cord-015021-pol2qm74 6434 18 licking lick VBG cord-015021-pol2qm74 6434 19 response response NN cord-015021-pol2qm74 6434 20 was be VBD cord-015021-pol2qm74 6434 21 observed observe VBN cord-015021-pol2qm74 6434 22 which which WDT cord-015021-pol2qm74 6434 23 was be VBD cord-015021-pol2qm74 6434 24 biphasic biphasic JJ cord-015021-pol2qm74 6434 25 in in IN cord-015021-pol2qm74 6434 26 nature nature NN cord-015021-pol2qm74 6434 27 . . . cord-015021-pol2qm74 6435 1 CP-0127 CP-0127 NNP cord-015021-pol2qm74 6435 2 significantly significantly RB cord-015021-pol2qm74 6435 3 inhibited inhibit VBD cord-015021-pol2qm74 6435 4 both both CC cord-015021-pol2qm74 6435 5 the the DT cord-015021-pol2qm74 6435 6 first first JJ cord-015021-pol2qm74 6435 7 ( ( -LRB- cord-015021-pol2qm74 6435 8 0 0 CD cord-015021-pol2qm74 6435 9 - - HYPH cord-015021-pol2qm74 6435 10 5min 5min CD cord-015021-pol2qm74 6435 11 ) ) -RRB- cord-015021-pol2qm74 6435 12 and and CC cord-015021-pol2qm74 6435 13 second second JJ cord-015021-pol2qm74 6435 14 ( ( -LRB- cord-015021-pol2qm74 6435 15 15 15 CD cord-015021-pol2qm74 6435 16 - - SYM cord-015021-pol2qm74 6435 17 30 30 CD cord-015021-pol2qm74 6435 18 min min NN cord-015021-pol2qm74 6435 19 ) ) -RRB- cord-015021-pol2qm74 6435 20 phase phase NN cord-015021-pol2qm74 6435 21 responses response NNS cord-015021-pol2qm74 6435 22 . . . cord-015021-pol2qm74 6435 23 ] ] -RRB- cord-015021-pol2qm74 6436 1 n n LS cord-015021-pol2qm74 6436 2 a a DT cord-015021-pol2qm74 6436 3 rat rat NN cord-015021-pol2qm74 6436 4 burn burn NN cord-015021-pol2qm74 6436 5 model model NN cord-015021-pol2qm74 6436 6 , , , cord-015021-pol2qm74 6436 7 where where WRB cord-015021-pol2qm74 6436 8 the the DT cord-015021-pol2qm74 6436 9 hind hind NN cord-015021-pol2qm74 6436 10 paw paw NNP cord-015021-pol2qm74 6436 11 is be VBZ cord-015021-pol2qm74 6436 12 immersed immerse VBN cord-015021-pol2qm74 6436 13 in in IN cord-015021-pol2qm74 6436 14 water water NN cord-015021-pol2qm74 6436 15 at at IN cord-015021-pol2qm74 6436 16 55 55 CD cord-015021-pol2qm74 6436 17 ° ° NN cord-015021-pol2qm74 6436 18 C c NN cord-015021-pol2qm74 6436 19 for for IN cord-015021-pol2qm74 6436 20 15 15 CD cord-015021-pol2qm74 6436 21 sec sec NNP cord-015021-pol2qm74 6437 1 the the DT cord-015021-pol2qm74 6437 2 increase increase NN cord-015021-pol2qm74 6437 3 in in IN cord-015021-pol2qm74 6437 4 paw paw NN cord-015021-pol2qm74 6437 5 volume volume NN cord-015021-pol2qm74 6437 6 was be VBD cord-015021-pol2qm74 6437 7 significantly significantly RB cord-015021-pol2qm74 6437 8 reduced reduce VBN cord-015021-pol2qm74 6437 9 by by IN cord-015021-pol2qm74 6437 10 pretreatment pretreatment NN cord-015021-pol2qm74 6437 11 with with IN cord-015021-pol2qm74 6437 12 CP-0127 CP-0127 NNP cord-015021-pol2qm74 6437 13 , , , cord-015021-pol2qm74 6437 14 3.6 3.6 CD cord-015021-pol2qm74 6437 15 umoles umoles NNPS cord-015021-pol2qm74 6437 16 / / SYM cord-015021-pol2qm74 6437 17 kg kg NNP cord-015021-pol2qm74 6437 18 s.c s.c NNP cord-015021-pol2qm74 6437 19 . . . cord-015021-pol2qm74 6438 1 Finally finally RB cord-015021-pol2qm74 6438 2 cerebrai cerebrai NNP cord-015021-pol2qm74 6438 3 edema edema NN cord-015021-pol2qm74 6438 4 was be VBD cord-015021-pol2qm74 6438 5 induced induce VBN cord-015021-pol2qm74 6438 6 in in IN cord-015021-pol2qm74 6438 7 rats rat NNS cord-015021-pol2qm74 6438 8 by by IN cord-015021-pol2qm74 6438 9 applying apply VBG cord-015021-pol2qm74 6438 10 cold cold JJ cord-015021-pol2qm74 6438 11 ( ( -LRB- cord-015021-pol2qm74 6438 12 -78 -78 NN cord-015021-pol2qm74 6438 13 ° ° NN cord-015021-pol2qm74 6438 14 C c NN cord-015021-pol2qm74 6438 15 for for IN cord-015021-pol2qm74 6438 16 10 10 CD cord-015021-pol2qm74 6438 17 sec sec NNP cord-015021-pol2qm74 6438 18 ) ) -RRB- cord-015021-pol2qm74 6438 19 to to IN cord-015021-pol2qm74 6438 20 the the DT cord-015021-pol2qm74 6438 21 dural dural NN cord-015021-pol2qm74 6438 22 surface surface NN cord-015021-pol2qm74 6438 23 following follow VBG cord-015021-pol2qm74 6438 24 a a DT cord-015021-pol2qm74 6438 25 craniectomy craniectomy NN cord-015021-pol2qm74 6438 26 . . . cord-015021-pol2qm74 6439 1 CP-0127 CP-0127 NNP cord-015021-pol2qm74 6439 2 at at IN cord-015021-pol2qm74 6439 3 3.6 3.6 CD cord-015021-pol2qm74 6439 4 umoles umoles NNPS cord-015021-pol2qm74 6439 5 / / SYM cord-015021-pol2qm74 6439 6 kg kg NNP cord-015021-pol2qm74 6439 7 s.c s.c NNP cord-015021-pol2qm74 6439 8 . . NNP cord-015021-pol2qm74 6439 9 produced produce VBD cord-015021-pol2qm74 6439 10 a a DT cord-015021-pol2qm74 6439 11 significant significant JJ cord-015021-pol2qm74 6439 12 reduction reduction NN cord-015021-pol2qm74 6439 13 in in IN cord-015021-pol2qm74 6439 14 the the DT cord-015021-pol2qm74 6439 15 amount amount NN cord-015021-pol2qm74 6439 16 of of IN cord-015021-pol2qm74 6439 17 edema edema NN cord-015021-pol2qm74 6439 18 compared compare VBN cord-015021-pol2qm74 6439 19 with with IN cord-015021-pol2qm74 6439 20 sham sham NN cord-015021-pol2qm74 6439 21 controls control VBZ cord-015021-pol2qm74 6439 22 24 24 CD cord-015021-pol2qm74 6439 23 h h NNP cord-015021-pol2qm74 6439 24 later later RB cord-015021-pol2qm74 6439 25 . . . cord-015021-pol2qm74 6440 1 These these DT cord-015021-pol2qm74 6440 2 data datum NNS cord-015021-pol2qm74 6440 3 suggest suggest VBP cord-015021-pol2qm74 6440 4 that that IN cord-015021-pol2qm74 6440 5 BK BK NNP cord-015021-pol2qm74 6440 6 is be VBZ cord-015021-pol2qm74 6440 7 an an DT cord-015021-pol2qm74 6440 8 important important JJ cord-015021-pol2qm74 6440 9 mediator mediator NN cord-015021-pol2qm74 6440 10 of of IN cord-015021-pol2qm74 6440 11 inflammation inflammation NN cord-015021-pol2qm74 6440 12 and and CC cord-015021-pol2qm74 6440 13 hyperalgesia hyperalgesia NN cord-015021-pol2qm74 6440 14 and and CC cord-015021-pol2qm74 6440 15 that that IN cord-015021-pol2qm74 6440 16 the the DT cord-015021-pol2qm74 6440 17 bradykinin bradykinin NN cord-015021-pol2qm74 6440 18 antagonist antagonist NN cord-015021-pol2qm74 6440 19 , , , cord-015021-pol2qm74 6440 20 CP-0127 CP-0127 NNP cord-015021-pol2qm74 6440 21 , , , cord-015021-pol2qm74 6440 22 may may MD cord-015021-pol2qm74 6440 23 be be VB cord-015021-pol2qm74 6440 24 useful useful JJ cord-015021-pol2qm74 6440 25 in in IN cord-015021-pol2qm74 6440 26 the the DT cord-015021-pol2qm74 6440 27 treatment treatment NN cord-015021-pol2qm74 6440 28 of of IN cord-015021-pol2qm74 6440 29 such such JJ cord-015021-pol2qm74 6440 30 inflammatory inflammatory JJ cord-015021-pol2qm74 6440 31 , , , cord-015021-pol2qm74 6440 32 hyperalgesic hyperalgesic NN cord-015021-pol2qm74 6440 33 disorders disorder NNS cord-015021-pol2qm74 6440 34 . . . cord-015021-pol2qm74 6441 1 Partial partial JJ cord-015021-pol2qm74 6441 2 hepatectomy hepatectomy NN cord-015021-pol2qm74 6441 3 in in IN cord-015021-pol2qm74 6441 4 humans human NNS cord-015021-pol2qm74 6441 5 is be VBZ cord-015021-pol2qm74 6441 6 associated associate VBN cord-015021-pol2qm74 6441 7 with with IN cord-015021-pol2qm74 6441 8 a a DT cord-015021-pol2qm74 6441 9 considerable considerable JJ cord-015021-pol2qm74 6441 10 morbidity morbidity NN cord-015021-pol2qm74 6441 11 due due IN cord-015021-pol2qm74 6441 12 to to IN cord-015021-pol2qm74 6441 13 hemodynamic hemodynamic JJ cord-015021-pol2qm74 6441 14 and and CC cord-015021-pol2qm74 6441 15 metabolic metabolic JJ cord-015021-pol2qm74 6441 16 derangements derangement NNS cord-015021-pol2qm74 6441 17 , , , cord-015021-pol2qm74 6441 18 which which WDT cord-015021-pol2qm74 6441 19 increase increase VBP cord-015021-pol2qm74 6441 20 the the DT cord-015021-pol2qm74 6441 21 risk risk NN cord-015021-pol2qm74 6441 22 for for IN cord-015021-pol2qm74 6441 23 organ organ NN cord-015021-pol2qm74 6441 24 failure failure NN cord-015021-pol2qm74 6441 25 and and CC cord-015021-pol2qm74 6441 26 mortality mortality NN cord-015021-pol2qm74 6441 27 . . . cord-015021-pol2qm74 6442 1 We -PRON- PRP cord-015021-pol2qm74 6442 2 hypothesized hypothesize VBD cord-015021-pol2qm74 6442 3 that that IN cord-015021-pol2qm74 6442 4 endotoxemia endotoxemia NN cord-015021-pol2qm74 6442 5 may may MD cord-015021-pol2qm74 6442 6 play play VB cord-015021-pol2qm74 6442 7 a a DT cord-015021-pol2qm74 6442 8 pivotal pivotal JJ cord-015021-pol2qm74 6442 9 role role NN cord-015021-pol2qm74 6442 10 in in IN cord-015021-pol2qm74 6442 11 these these DT cord-015021-pol2qm74 6442 12 complications complication NNS cord-015021-pol2qm74 6442 13 . . . cord-015021-pol2qm74 6443 1 We -PRON- PRP cord-015021-pol2qm74 6443 2 therefore therefore RB cord-015021-pol2qm74 6443 3 , , , cord-015021-pol2qm74 6443 4 investigated investigate VBD cord-015021-pol2qm74 6443 5 whether whether IN cord-015021-pol2qm74 6443 6 peri peri JJ cord-015021-pol2qm74 6443 7 - - HYPH cord-015021-pol2qm74 6443 8 operative operative JJ cord-015021-pol2qm74 6443 9 infusion infusion NN cord-015021-pol2qm74 6443 10 of of IN cord-015021-pol2qm74 6443 11 rBPI23 rBPI23 NNP cord-015021-pol2qm74 6443 12 , , , cord-015021-pol2qm74 6443 13 a a DT cord-015021-pol2qm74 6443 14 recombinant recombinant JJ cord-015021-pol2qm74 6443 15 protein protein NN cord-015021-pol2qm74 6443 16 of of IN cord-015021-pol2qm74 6443 17 the the DT cord-015021-pol2qm74 6443 18 human human JJ cord-015021-pol2qm74 6443 19 neutrophil neutrophil NN cord-015021-pol2qm74 6443 20 BPI BPI NNP cord-015021-pol2qm74 6443 21 with with IN cord-015021-pol2qm74 6443 22 bactericidal bactericidal JJ cord-015021-pol2qm74 6443 23 and and CC cord-015021-pol2qm74 6443 24 endotoxin endotoxin NN cord-015021-pol2qm74 6443 25 - - HYPH cord-015021-pol2qm74 6443 26 binding bind VBG cord-015021-pol2qm74 6443 27 capacity capacity NN cord-015021-pol2qm74 6443 28 , , , cord-015021-pol2qm74 6443 29 could could MD cord-015021-pol2qm74 6443 30 prevent prevent VB cord-015021-pol2qm74 6443 31 postoperative postoperative JJ cord-015021-pol2qm74 6443 32 derangements derangement NNS cord-015021-pol2qm74 6443 33 following follow VBG cord-015021-pol2qm74 6443 34 partial partial JJ cord-015021-pol2qm74 6443 35 hepatectomy hepatectomy NN cord-015021-pol2qm74 6443 36 . . . cord-015021-pol2qm74 6444 1 Male male JJ cord-015021-pol2qm74 6444 2 Wistar Wistar NNP cord-015021-pol2qm74 6444 3 rats rat NNS cord-015021-pol2qm74 6444 4 ( ( -LRB- cord-015021-pol2qm74 6444 5 230 230 CD cord-015021-pol2qm74 6444 6 - - SYM cord-015021-pol2qm74 6444 7 250 250 CD cord-015021-pol2qm74 6444 8 g. g. NNP cord-015021-pol2qm74 6444 9 ) ) -RRB- cord-015021-pol2qm74 6444 10 received receive VBD cord-015021-pol2qm74 6444 11 a a DT cord-015021-pol2qm74 6444 12 70 70 CD cord-015021-pol2qm74 6444 13 % % NN cord-015021-pol2qm74 6444 14 liver liver NN cord-015021-pol2qm74 6444 15 resection resection NN cord-015021-pol2qm74 6444 16 ( ( -LRB- cord-015021-pol2qm74 6444 17 phx phx NNP cord-015021-pol2qm74 6444 18 ) ) -RRB- cord-015021-pol2qm74 6444 19 or or CC cord-015021-pol2qm74 6444 20 a a DT cord-015021-pol2qm74 6444 21 sham sham JJ cord-015021-pol2qm74 6444 22 operation operation NN cord-015021-pol2qm74 6444 23 ( ( -LRB- cord-015021-pol2qm74 6444 24 sh sh NNP cord-015021-pol2qm74 6444 25 ) ) -RRB- cord-015021-pol2qm74 6444 26 , , , cord-015021-pol2qm74 6444 27 and and CC cord-015021-pol2qm74 6444 28 a a DT cord-015021-pol2qm74 6444 29 continuous continuous JJ cord-015021-pol2qm74 6444 30 intravenous intravenous JJ cord-015021-pol2qm74 6444 31 infusion infusion NN cord-015021-pol2qm74 6444 32 of of IN cord-015021-pol2qm74 6444 33 either either DT cord-015021-pol2qm74 6444 34 0.2 0.2 CD cord-015021-pol2qm74 6444 35 mg mg NNP cord-015021-pol2qm74 6444 36 / / SYM cord-015021-pol2qm74 6444 37 kg kg NNP cord-015021-pol2qm74 6444 38 / / SYM cord-015021-pol2qm74 6444 39 hr hr NN cord-015021-pol2qm74 6445 1 rBPI23 rBPI23 NNP cord-015021-pol2qm74 6445 2 ( ( -LRB- cord-015021-pol2qm74 6445 3 phx phx NNP cord-015021-pol2qm74 6445 4 - - HYPH cord-015021-pol2qm74 6445 5 bpi bpi NNP cord-015021-pol2qm74 6445 6 , , , cord-015021-pol2qm74 6445 7 n=8 n=8 NN cord-015021-pol2qm74 6445 8 ; ; : cord-015021-pol2qm74 6445 9 sh sh NNP cord-015021-pol2qm74 6445 10 - - HYPH cord-015021-pol2qm74 6445 11 bpi bpi NNP cord-015021-pol2qm74 6445 12 , , , cord-015021-pol2qm74 6445 13 n=7 n=7 NNS cord-015021-pol2qm74 6445 14 ) ) -RRB- cord-015021-pol2qm74 6445 15 or or CC cord-015021-pol2qm74 6445 16 the the DT cord-015021-pol2qm74 6445 17 ( ( -LRB- cord-015021-pol2qm74 6445 18 iso iso JJ cord-015021-pol2qm74 6445 19 - - HYPH cord-015021-pol2qm74 6445 20 electric electric JJ cord-015021-pol2qm74 6446 1 , , , cord-015021-pol2qm74 6446 2 iso iso NNP cord-015021-pol2qm74 6446 3 - - HYPH cord-015021-pol2qm74 6446 4 kD kd JJ cord-015021-pol2qm74 6446 5 ) ) -RRB- cord-015021-pol2qm74 6446 6 control control NN cord-015021-pol2qm74 6446 7 protein protein NN cord-015021-pol2qm74 6446 8 thaumatin thaumatin NNP cord-015021-pol2qm74 6446 9 ( ( -LRB- cord-015021-pol2qm74 6446 10 phx phx NNP cord-015021-pol2qm74 6446 11 - - HYPH cord-015021-pol2qm74 6446 12 con con NNP cord-015021-pol2qm74 6446 13 , , , cord-015021-pol2qm74 6446 14 n=8 n=8 NN cord-015021-pol2qm74 6446 15 ; ; : cord-015021-pol2qm74 6446 16 sh sh NN cord-015021-pol2qm74 6446 17 - - HYPH cord-015021-pol2qm74 6446 18 con con NN cord-015021-pol2qm74 6446 19 , , , cord-015021-pol2qm74 6446 20 n-8 n-8 NNP cord-015021-pol2qm74 6446 21 ) ) -RRB- cord-015021-pol2qm74 6446 22 . . . cord-015021-pol2qm74 6447 1 Various various JJ cord-015021-pol2qm74 6447 2 parameters parameter NNS cord-015021-pol2qm74 6447 3 were be VBD cord-015021-pol2qm74 6447 4 measured measure VBN cord-015021-pol2qm74 6447 5 4 4 CD cord-015021-pol2qm74 6447 6 h h NN cord-015021-pol2qm74 6447 7 after after IN cord-015021-pol2qm74 6447 8 the the DT cord-015021-pol2qm74 6447 9 resection resection NN cord-015021-pol2qm74 6447 10 or or CC cord-015021-pol2qm74 6447 11 sham sham NN cord-015021-pol2qm74 6447 12 operation operation NN cord-015021-pol2qm74 6447 13 . . . cord-015021-pol2qm74 6448 1 Mean mean JJ cord-015021-pol2qm74 6448 2 arterial arterial JJ cord-015021-pol2qm74 6448 3 pressure pressure NN cord-015021-pol2qm74 6448 4 , , , cord-015021-pol2qm74 6448 5 cardiac cardiac JJ cord-015021-pol2qm74 6448 6 output output NN cord-015021-pol2qm74 6448 7 and and CC cord-015021-pol2qm74 6448 8 heart heart NN cord-015021-pol2qm74 6448 9 rate rate NN cord-015021-pol2qm74 6448 10 were be VBD cord-015021-pol2qm74 6448 11 significantly significantly RB cord-015021-pol2qm74 6448 12 decreased decrease VBN cord-015021-pol2qm74 6448 13 in in IN cord-015021-pol2qm74 6448 14 phx phx NNP cord-015021-pol2qm74 6448 15 - - HYPH cord-015021-pol2qm74 6448 16 con con NN cord-015021-pol2qm74 6448 17 rats rat NNS cord-015021-pol2qm74 6448 18 compared compare VBN cord-015021-pol2qm74 6448 19 with with IN cord-015021-pol2qm74 6448 20 sh sh NNP cord-015021-pol2qm74 6448 21 rats rat NNS cord-015021-pol2qm74 6448 22 , , , cord-015021-pol2qm74 6448 23 which which WDT cord-015021-pol2qm74 6448 24 effects effect NNS cord-015021-pol2qm74 6448 25 were be VBD cord-015021-pol2qm74 6448 26 not not RB cord-015021-pol2qm74 6448 27 observed observe VBN cord-015021-pol2qm74 6448 28 in in IN cord-015021-pol2qm74 6448 29 phx phx NNP cord-015021-pol2qm74 6448 30 rats rat NNS cord-015021-pol2qm74 6448 31 treated treat VBN cord-015021-pol2qm74 6448 32 with with IN cord-015021-pol2qm74 6448 33 rBPI23 rBPI23 NNP cord-015021-pol2qm74 6448 34 . . . cord-015021-pol2qm74 6449 1 Blood blood NN cord-015021-pol2qm74 6449 2 pH pH NNP cord-015021-pol2qm74 6449 3 was be VBD cord-015021-pol2qm74 6449 4 significantly significantly RB cord-015021-pol2qm74 6449 5 decreased decrease VBN cord-015021-pol2qm74 6449 6 in in IN cord-015021-pol2qm74 6449 7 the the DT cord-015021-pol2qm74 6449 8 phx phx NNP cord-015021-pol2qm74 6449 9 - - HYPH cord-015021-pol2qm74 6449 10 eon eon NNP cord-015021-pol2qm74 6449 11 group group NN cord-015021-pol2qm74 6449 12 , , , cord-015021-pol2qm74 6449 13 whereas whereas IN cord-015021-pol2qm74 6449 14 the the DT cord-015021-pol2qm74 6449 15 leucocyte leucocyte NNP cord-015021-pol2qm74 6449 16 count count NNP cord-015021-pol2qm74 6449 17 , , , cord-015021-pol2qm74 6449 18 hematocrite hematocrite NNP cord-015021-pol2qm74 6449 19 and and CC cord-015021-pol2qm74 6449 20 IL-6 IL-6 NNP cord-015021-pol2qm74 6449 21 levels level NNS cord-015021-pol2qm74 6449 22 were be VBD cord-015021-pol2qm74 6449 23 significantly significantly RB cord-015021-pol2qm74 6449 24 increased increase VBN cord-015021-pol2qm74 6449 25 compared compare VBN cord-015021-pol2qm74 6449 26 to to IN cord-015021-pol2qm74 6449 27 sham sham JJ cord-015021-pol2qm74 6449 28 levels level NNS cord-015021-pol2qm74 6449 29 . . . cord-015021-pol2qm74 6450 1 In in IN cord-015021-pol2qm74 6450 2 the the DT cord-015021-pol2qm74 6450 3 phx phx NNP cord-015021-pol2qm74 6450 4 - - HYPH cord-015021-pol2qm74 6450 5 bpi bpi NNP cord-015021-pol2qm74 6450 6 group group NN cord-015021-pol2qm74 6450 7 , , , cord-015021-pol2qm74 6450 8 these these DT cord-015021-pol2qm74 6450 9 parameters parameter NNS cord-015021-pol2qm74 6450 10 were be VBD cord-015021-pol2qm74 6450 11 restored restore VBN cord-015021-pol2qm74 6450 12 to to IN cord-015021-pol2qm74 6450 13 near near IN cord-015021-pol2qm74 6450 14 sham sham JJ cord-015021-pol2qm74 6450 15 levels level NNS cord-015021-pol2qm74 6450 16 . . . cord-015021-pol2qm74 6451 1 In in IN cord-015021-pol2qm74 6451 2 vitro vitro FW cord-015021-pol2qm74 6451 3 experiments experiment NNS cord-015021-pol2qm74 6451 4 with with IN cord-015021-pol2qm74 6451 5 rat rat NN cord-015021-pol2qm74 6451 6 plasma plasma NN cord-015021-pol2qm74 6451 7 and and CC cord-015021-pol2qm74 6451 8 human human JJ cord-015021-pol2qm74 6451 9 mononuclear mononuclear NN cord-015021-pol2qm74 6451 10 cells cell NNS cord-015021-pol2qm74 6451 11 ( ( -LRB- cord-015021-pol2qm74 6451 12 MNCs mnc NNS cord-015021-pol2qm74 6451 13 ) ) -RRB- cord-015021-pol2qm74 6451 14 revealed reveal VBD cord-015021-pol2qm74 6451 15 that that IN cord-015021-pol2qm74 6451 16 plasma plasma NN cord-015021-pol2qm74 6451 17 of of IN cord-015021-pol2qm74 6451 18 phx phx NNP cord-015021-pol2qm74 6451 19 - - HYPH cord-015021-pol2qm74 6451 20 con con NN cord-015021-pol2qm74 6451 21 rats rat NNS cord-015021-pol2qm74 6451 22 is be VBZ cord-015021-pol2qm74 6451 23 highly highly RB cord-015021-pol2qm74 6451 24 capable capable JJ cord-015021-pol2qm74 6451 25 of of IN cord-015021-pol2qm74 6451 26 activating activate VBG cord-015021-pol2qm74 6451 27 MNCs mnc NNS cord-015021-pol2qm74 6451 28 , , , cord-015021-pol2qm74 6451 29 accompanied accompany VBN cord-015021-pol2qm74 6451 30 by by IN cord-015021-pol2qm74 6451 31 the the DT cord-015021-pol2qm74 6451 32 release release NN cord-015021-pol2qm74 6451 33 of of IN cord-015021-pol2qm74 6451 34 cytokines cytokine NNS cord-015021-pol2qm74 6451 35 . . . cord-015021-pol2qm74 6452 1 This this DT cord-015021-pol2qm74 6452 2 activation activation NN cord-015021-pol2qm74 6452 3 is be VBZ cord-015021-pol2qm74 6452 4 attenuated attenuate VBN cord-015021-pol2qm74 6452 5 with with IN cord-015021-pol2qm74 6452 6 phx phx NNP cord-015021-pol2qm74 6452 7 - - HYPH cord-015021-pol2qm74 6452 8 bpi bpi NNP cord-015021-pol2qm74 6452 9 plasma plasma NN cord-015021-pol2qm74 6452 10 . . . cord-015021-pol2qm74 6453 1 In in IN cord-015021-pol2qm74 6453 2 vitro vitro FW cord-015021-pol2qm74 6453 3 added add VBN cord-015021-pol2qm74 6453 4 aCD14 aCD14 NNP cord-015021-pol2qm74 6453 5 or or CC cord-015021-pol2qm74 6453 6 polymyxin polymyxin NN cord-015021-pol2qm74 6453 7 B B NNP cord-015021-pol2qm74 6453 8 was be VBD cord-015021-pol2qm74 6453 9 able able JJ cord-015021-pol2qm74 6453 10 to to TO cord-015021-pol2qm74 6453 11 reduce reduce VB cord-015021-pol2qm74 6453 12 the the DT cord-015021-pol2qm74 6453 13 activation activation NN cord-015021-pol2qm74 6453 14 by by IN cord-015021-pol2qm74 6453 15 phx phx NNP cord-015021-pol2qm74 6453 16 - - HYPH cord-015021-pol2qm74 6453 17 con con FW cord-015021-pol2qm74 6453 18 rat rat NN cord-015021-pol2qm74 6453 19 plasma plasma NN cord-015021-pol2qm74 6453 20 to to IN cord-015021-pol2qm74 6453 21 the the DT cord-015021-pol2qm74 6453 22 levels level NNS cord-015021-pol2qm74 6453 23 of of IN cord-015021-pol2qm74 6453 24 phx phx NNP cord-015021-pol2qm74 6453 25 - - HYPH cord-015021-pol2qm74 6453 26 bpi bpi NNP cord-015021-pol2qm74 6453 27 rats rat NNS cord-015021-pol2qm74 6454 1 Thus thus RB cord-015021-pol2qm74 6454 2 , , , cord-015021-pol2qm74 6454 3 these these DT cord-015021-pol2qm74 6454 4 data datum NNS cord-015021-pol2qm74 6454 5 suggest suggest VBP cord-015021-pol2qm74 6454 6 that that IN cord-015021-pol2qm74 6454 7 systemic systemic JJ cord-015021-pol2qm74 6454 8 endctoxemia endctoxemia NN cord-015021-pol2qm74 6454 9 , , , cord-015021-pol2qm74 6454 10 possibly possibly RB cord-015021-pol2qm74 6454 11 of of IN cord-015021-pol2qm74 6454 12 gut gut NN cord-015021-pol2qm74 6454 13 origin origin NN cord-015021-pol2qm74 6454 14 , , , cord-015021-pol2qm74 6454 15 is be VBZ cord-015021-pol2qm74 6454 16 a a DT cord-015021-pol2qm74 6454 17 major major JJ cord-015021-pol2qm74 6454 18 cause cause NN cord-015021-pol2qm74 6454 19 of of IN cord-015021-pol2qm74 6454 20 postoperative postoperative JJ cord-015021-pol2qm74 6454 21 hemodynamic hemodynamic JJ cord-015021-pol2qm74 6454 22 and and CC cord-015021-pol2qm74 6454 23 metabolic metabolic JJ cord-015021-pol2qm74 6454 24 derangements derangement NNS cord-015021-pol2qm74 6454 25 following follow VBG cord-015021-pol2qm74 6454 26 phx phx NNP cord-015021-pol2qm74 6454 27 and and CC cord-015021-pol2qm74 6454 28 that that IN cord-015021-pol2qm74 6454 29 rBPIzz rBPIzz NNS cord-015021-pol2qm74 6454 30 can can MD cord-015021-pol2qm74 6454 31 prevent prevent VB cord-015021-pol2qm74 6454 32 these these DT cord-015021-pol2qm74 6454 33 changes change NNS cord-015021-pol2qm74 6454 34 . . . cord-015021-pol2qm74 6455 1 More more RBR cord-015021-pol2qm74 6455 2 recently recently RB cord-015021-pol2qm74 6455 3 we -PRON- PRP cord-015021-pol2qm74 6455 4 reported report VBD cord-015021-pol2qm74 6455 5 a a DT cord-015021-pol2qm74 6455 6 transient transient JJ cord-015021-pol2qm74 6455 7 appearance appearance NN cord-015021-pol2qm74 6455 8 of of IN cord-015021-pol2qm74 6455 9 both both DT cord-015021-pol2qm74 6455 10 endotoxin endotoxin NN cord-015021-pol2qm74 6455 11 and and CC cord-015021-pol2qm74 6455 12 TNF TNF NNP cord-015021-pol2qm74 6455 13 in in IN cord-015021-pol2qm74 6455 14 the the DT cord-015021-pol2qm74 6455 15 circulation circulation NN cord-015021-pol2qm74 6455 16 of of IN cord-015021-pol2qm74 6455 17 rats rat NNS cord-015021-pol2qm74 6455 18 subjected subject VBN cord-015021-pol2qm74 6455 19 to to IN cord-015021-pol2qm74 6455 20 the the DT cord-015021-pol2qm74 6455 21 haemorrhagic haemorrhagic JJ cord-015021-pol2qm74 6455 22 shock shock NN cord-015021-pol2qm74 6455 23 ( ( -LRB- cord-015021-pol2qm74 6455 24 HS HS NNP cord-015021-pol2qm74 6455 25 ) ) -RRB- cord-015021-pol2qm74 6455 26 already already RB cord-015021-pol2qm74 6455 27 at at IN cord-015021-pol2qm74 6455 28 90 90 CD cord-015021-pol2qm74 6455 29 -120 -120 NN cord-015021-pol2qm74 6455 30 rain rain NN cord-015021-pol2qm74 6455 31 . . . cord-015021-pol2qm74 6456 1 Similar similar JJ cord-015021-pol2qm74 6456 2 to to IN cord-015021-pol2qm74 6456 3 BPI BPI NNP cord-015021-pol2qm74 6456 4 , , , cord-015021-pol2qm74 6456 5 recombinant recombinant JJ cord-015021-pol2qm74 6456 6 BPI BPI NNP cord-015021-pol2qm74 6456 7 was be VBD cord-015021-pol2qm74 6456 8 found find VBN cord-015021-pol2qm74 6456 9 to to TO cord-015021-pol2qm74 6456 10 bind bind VB cord-015021-pol2qm74 6456 11 LPS LPS NNP cord-015021-pol2qm74 6456 12 and and CC cord-015021-pol2qm74 6456 13 inhibit inhibit VB cord-015021-pol2qm74 6456 14 TNF TNF NNP cord-015021-pol2qm74 6456 15 formation formation NN cord-015021-pol2qm74 6456 16 in in IN cord-015021-pol2qm74 6456 17 vitro vitro FW cord-015021-pol2qm74 6456 18 . . . cord-015021-pol2qm74 6457 1 The the DT cord-015021-pol2qm74 6457 2 aim aim NN cord-015021-pol2qm74 6457 3 of of IN cord-015021-pol2qm74 6457 4 this this DT cord-015021-pol2qm74 6457 5 study study NN cord-015021-pol2qm74 6457 6 was be VBD cord-015021-pol2qm74 6457 7 to to TO cord-015021-pol2qm74 6457 8 investigate investigate VB cord-015021-pol2qm74 6457 9 the the DT cord-015021-pol2qm74 6457 10 effects effect NNS cord-015021-pol2qm74 6457 11 of of IN cord-015021-pol2qm74 6457 12 rBPI21 rBPI21 NNP cord-015021-pol2qm74 6457 13 ( ( -LRB- cord-015021-pol2qm74 6457 14 kindly kindly RB cord-015021-pol2qm74 6457 15 provided provide VBN cord-015021-pol2qm74 6457 16 by by IN cord-015021-pol2qm74 6457 17 Xoma Xoma NNP cord-015021-pol2qm74 6457 18 corporation corporation NN cord-015021-pol2qm74 6457 19 , , , cord-015021-pol2qm74 6457 20 Berkeley Berkeley NNP cord-015021-pol2qm74 6457 21 , , , cord-015021-pol2qm74 6457 22 CA CA NNP cord-015021-pol2qm74 6457 23 ) ) -RRB- cord-015021-pol2qm74 6457 24 against against IN cord-015021-pol2qm74 6457 25 haemorrhage haemorrhage NN cord-015021-pol2qm74 6457 26 related relate VBN cord-015021-pol2qm74 6457 27 endotoxemia endotoxemia NN cord-015021-pol2qm74 6457 28 and and CC cord-015021-pol2qm74 6457 29 mortality mortality NN cord-015021-pol2qm74 6457 30 in in IN cord-015021-pol2qm74 6457 31 rats rat NNS cord-015021-pol2qm74 6457 32 . . . cord-015021-pol2qm74 6458 1 Method method NN cord-015021-pol2qm74 6458 2 : : : cord-015021-pol2qm74 6459 1 A a DT cord-015021-pol2qm74 6459 2 prolonged prolonged JJ cord-015021-pol2qm74 6459 3 HS hs NN cord-015021-pol2qm74 6459 4 was be VBD cord-015021-pol2qm74 6459 5 induced induce VBN cord-015021-pol2qm74 6459 6 by by IN cord-015021-pol2qm74 6459 7 blood blood NN cord-015021-pol2qm74 6459 8 withdrawal withdrawal NN cord-015021-pol2qm74 6459 9 to to IN cord-015021-pol2qm74 6459 10 a a DT cord-015021-pol2qm74 6459 11 mean mean JJ cord-015021-pol2qm74 6459 12 arterial arterial JJ cord-015021-pol2qm74 6459 13 pressure pressure NN cord-015021-pol2qm74 6459 14 of of IN cord-015021-pol2qm74 6459 15 30 30 CD cord-015021-pol2qm74 6459 16 - - SYM cord-015021-pol2qm74 6459 17 35 35 CD cord-015021-pol2qm74 6459 18 mmHg mmHg NNS cord-015021-pol2qm74 6459 19 for for IN cord-015021-pol2qm74 6459 20 180 180 CD cord-015021-pol2qm74 6459 21 rain rain NN cord-015021-pol2qm74 6459 22 followed follow VBN cord-015021-pol2qm74 6459 23 by by IN cord-015021-pol2qm74 6459 24 reinfusion reinfusion NN cord-015021-pol2qm74 6459 25 of of IN cord-015021-pol2qm74 6459 26 shed shed JJ cord-015021-pol2qm74 6459 27 blood blood NN cord-015021-pol2qm74 6459 28 ( ( -LRB- cord-015021-pol2qm74 6459 29 SB SB NNP cord-015021-pol2qm74 6459 30 ) ) -RRB- cord-015021-pol2qm74 6459 31 and and CC cord-015021-pol2qm74 6459 32 resuscitation resuscitation NN cord-015021-pol2qm74 6459 33 with with IN cord-015021-pol2qm74 6459 34 two two CD cord-015021-pol2qm74 6459 35 times time NNS cord-015021-pol2qm74 6459 36 of of IN cord-015021-pol2qm74 6459 37 SB SB NNP cord-015021-pol2qm74 6459 38 volume volume NN cord-015021-pol2qm74 6459 39 of of IN cord-015021-pol2qm74 6459 40 Ringer Ringer NNP cord-015021-pol2qm74 6459 41 's 's POS cord-015021-pol2qm74 6459 42 lactate lactate NN cord-015021-pol2qm74 6459 43 over over IN cord-015021-pol2qm74 6459 44 50 50 CD cord-015021-pol2qm74 6459 45 rain rain NN cord-015021-pol2qm74 6459 46 . . . cord-015021-pol2qm74 6460 1 rBPlg rBPlg NNP cord-015021-pol2qm74 6460 2 . . . cord-015021-pol2qm74 6461 1 1 1 CD cord-015021-pol2qm74 6461 2 was be VBD cord-015021-pol2qm74 6461 3 administered administer VBN cord-015021-pol2qm74 6461 4 at at IN cord-015021-pol2qm74 6461 5 a a DT cord-015021-pol2qm74 6461 6 total total JJ cord-015021-pol2qm74 6461 7 dose dose NN cord-015021-pol2qm74 6461 8 of of IN cord-015021-pol2qm74 6461 9 5 5 CD cord-015021-pol2qm74 6461 10 mg mg NNP cord-015021-pol2qm74 6461 11 / / SYM cord-015021-pol2qm74 6461 12 kg kg NNP cord-015021-pol2qm74 6461 13 i.v i.v NNP cord-015021-pol2qm74 6461 14 . . . cord-015021-pol2qm74 6462 1 ( ( -LRB- cord-015021-pol2qm74 6462 2 2.0 2.0 CD cord-015021-pol2qm74 6462 3 mg mg NNP cord-015021-pol2qm74 6462 4 / / SYM cord-015021-pol2qm74 6462 5 kg kg NN cord-015021-pol2qm74 6462 6 at at IN cord-015021-pol2qm74 6462 7 the16-eginning the16-eginning NN cord-015021-pol2qm74 6462 8 followed follow VBN cord-015021-pol2qm74 6462 9 by by IN cord-015021-pol2qm74 6462 10 two two CD cord-015021-pol2qm74 6462 11 doses dose NNS cord-015021-pol2qm74 6462 12 of of IN cord-015021-pol2qm74 6462 13 1.5 1.5 CD cord-015021-pol2qm74 6462 14 mg mg NNP cord-015021-pol2qm74 6462 15 / / SYM cord-015021-pol2qm74 6462 16 kg kg VBZ cord-015021-pol2qm74 6462 17 each each DT cord-015021-pol2qm74 6462 18 at at IN cord-015021-pol2qm74 6462 19 end end NN cord-015021-pol2qm74 6462 20 of of IN cord-015021-pol2qm74 6462 21 shock shock NN cord-015021-pol2qm74 6462 22 and and CC cord-015021-pol2qm74 6462 23 the the DT cord-015021-pol2qm74 6462 24 end end NN cord-015021-pol2qm74 6462 25 of of IN cord-015021-pol2qm74 6462 26 resuscitation resuscitation NN cord-015021-pol2qm74 6462 27 ) ) -RRB- cord-015021-pol2qm74 6462 28 . . . cord-015021-pol2qm74 6463 1 The the DT cord-015021-pol2qm74 6463 2 control control NN cord-015021-pol2qm74 6463 3 group group NN cord-015021-pol2qm74 6463 4 was be VBD cord-015021-pol2qm74 6463 5 treated treat VBN cord-015021-pol2qm74 6463 6 similar similar JJ cord-015021-pol2qm74 6463 7 to to IN cord-015021-pol2qm74 6463 8 the the DT cord-015021-pol2qm74 6463 9 BPI BPI NNP cord-015021-pol2qm74 6463 10 group group NN cord-015021-pol2qm74 6463 11 but but CC cord-015021-pol2qm74 6463 12 received receive VBD cord-015021-pol2qm74 6463 13 thaumatin thaumatin NN cord-015021-pol2qm74 6463 14 as as IN cord-015021-pol2qm74 6463 15 a a DT cord-015021-pol2qm74 6463 16 protein protein NN cord-015021-pol2qm74 6463 17 control control NN cord-015021-pol2qm74 6463 18 preparation preparation NN cord-015021-pol2qm74 6463 19 at at IN cord-015021-pol2qm74 6463 20 the the DT cord-015021-pol2qm74 6463 21 same same JJ cord-015021-pol2qm74 6463 22 dose dose NN cord-015021-pol2qm74 6463 23 as as IN cord-015021-pol2qm74 6463 24 rBPI21 rBPI21 NNP cord-015021-pol2qm74 6463 25 . . . cord-015021-pol2qm74 6464 1 Results result NNS cord-015021-pol2qm74 6464 2 : : : cord-015021-pol2qm74 6465 1 Imrffe?diately imrffe?diately RB cord-015021-pol2qm74 6465 2 after after IN cord-015021-pol2qm74 6465 3 resuscitation resuscitation NN cord-015021-pol2qm74 6465 4 ( ( -LRB- cord-015021-pol2qm74 6465 5 230 230 CD cord-015021-pol2qm74 6465 6 min min NN cord-015021-pol2qm74 6465 7 ) ) -RRB- cord-015021-pol2qm74 6466 1 the the DT cord-015021-pol2qm74 6466 2 detected detect VBN cord-015021-pol2qm74 6466 3 plasma plasma NN cord-015021-pol2qm74 6466 4 endotoxin endotoxin NN cord-015021-pol2qm74 6466 5 levels level NNS cord-015021-pol2qm74 6466 6 in in IN cord-015021-pol2qm74 6466 7 the the DT cord-015021-pol2qm74 6466 8 control control NN cord-015021-pol2qm74 6466 9 group group NN cord-015021-pol2qm74 6466 10 ( ( -LRB- cord-015021-pol2qm74 6466 11 mean mean NNP cord-015021-pol2qm74 6466 12 = = SYM cord-015021-pol2qm74 6466 13 61 61 CD cord-015021-pol2qm74 6466 14 , , , cord-015021-pol2qm74 6466 15 range range NN cord-015021-pol2qm74 6466 16 = = SYM cord-015021-pol2qm74 6466 17 0 0 CD cord-015021-pol2qm74 6466 18 - - SYM cord-015021-pol2qm74 6466 19 120 120 CD cord-015021-pol2qm74 6466 20 pg pg NN cord-015021-pol2qm74 6466 21 / / SYM cord-015021-pol2qm74 6466 22 ml ml NN cord-015021-pol2qm74 6466 23 ) ) -RRB- cord-015021-pol2qm74 6466 24 were be VBD cord-015021-pol2qm74 6466 25 almost almost RB cord-015021-pol2qm74 6466 26 neutralized neutralize VBN cord-015021-pol2qm74 6466 27 by by IN cord-015021-pol2qm74 6466 28 rBPI21 rBPI21 NNP cord-015021-pol2qm74 6466 29 treatment treatment NN cord-015021-pol2qm74 6466 30 ( ( -LRB- cord-015021-pol2qm74 6466 31 mean mean VB cord-015021-pol2qm74 6466 32 = = SYM cord-015021-pol2qm74 6466 33 13 13 CD cord-015021-pol2qm74 6466 34 , , , cord-015021-pol2qm74 6466 35 range range NN cord-015021-pol2qm74 6466 36 = = SYM cord-015021-pol2qm74 6466 37 0 0 CD cord-015021-pol2qm74 6466 38 - - SYM cord-015021-pol2qm74 6466 39 53 53 CD cord-015021-pol2qm74 6466 40 pg pg NN cord-015021-pol2qm74 6466 41 / / SYM cord-015021-pol2qm74 6466 42 ml ml NN cord-015021-pol2qm74 6466 43 ) ) -RRB- cord-015021-pol2qm74 6466 44 . . . cord-015021-pol2qm74 6467 1 Plasma plasma NN cord-015021-pol2qm74 6467 2 TNF TNF NNP cord-015021-pol2qm74 6467 3 levYIs levYIs NNP cord-015021-pol2qm74 6467 4 were be VBD cord-015021-pol2qm74 6467 5 not not RB cord-015021-pol2qm74 6467 6 significantly significantly RB cord-015021-pol2qm74 6467 7 influenced influence VBN cord-015021-pol2qm74 6467 8 by by IN cord-015021-pol2qm74 6467 9 rBPI rbpi CD cord-015021-pol2qm74 6467 10 treatment treatment NN cord-015021-pol2qm74 6467 11 at at IN cord-015021-pol2qm74 6467 12 the the DT cord-015021-pol2qm74 6467 13 two two CD cord-015021-pol2qm74 6467 14 time time NN cord-015021-pol2qm74 6467 15 points point VBZ cord-015021-pol2qm74 6467 16 230 230 CD cord-015021-pol2qm74 6467 17 and and CC cord-015021-pol2qm74 6467 18 320 320 CD cord-015021-pol2qm74 6467 19 min min NN cord-015021-pol2qm74 6467 20 of of IN cord-015021-pol2qm74 6467 21 experiment experiment NN cord-015021-pol2qm74 6467 22 ( ( -LRB- cord-015021-pol2qm74 6467 23 means mean VBZ cord-015021-pol2qm74 6467 24 : : : cord-015021-pol2qm74 6467 25 65 65 CD cord-015021-pol2qm74 6467 26 and and CC cord-015021-pol2qm74 6467 27 51 51 CD cord-015021-pol2qm74 6467 28 in in IN cord-015021-pol2qm74 6467 29 BPI BPI NNP cord-015021-pol2qm74 6467 30 vs vs IN cord-015021-pol2qm74 6467 31 49 49 CD cord-015021-pol2qm74 6467 32 , , , cord-015021-pol2qm74 6467 33 65 65 CD cord-015021-pol2qm74 6467 34 pg pg NN cord-015021-pol2qm74 6467 35 / / SYM cord-015021-pol2qm74 6467 36 ml ml XX cord-015021-pol2qm74 6467 37 in in IN cord-015021-pol2qm74 6467 38 the the DT cord-015021-pol2qm74 6467 39 control control NN cord-015021-pol2qm74 6467 40 group group NN cord-015021-pol2qm74 6467 41 ) ) -RRB- cord-015021-pol2qm74 6467 42 . . . cord-015021-pol2qm74 6468 1 The the DT cord-015021-pol2qm74 6468 2 48-hour 48-hour JJ cord-015021-pol2qm74 6468 3 survival survival NN cord-015021-pol2qm74 6468 4 rate rate NN cord-015021-pol2qm74 6468 5 was be VBD cord-015021-pol2qm74 6468 6 improved improve VBN cord-015021-pol2qm74 6468 7 from from IN cord-015021-pol2qm74 6468 8 6/16 6/16 CD cord-015021-pol2qm74 6468 9 ( ( -LRB- cord-015021-pol2qm74 6468 10 37.5 37.5 CD cord-015021-pol2qm74 6468 11 % % NN cord-015021-pol2qm74 6468 12 ) ) -RRB- cord-015021-pol2qm74 6468 13 in in IN cord-015021-pol2qm74 6468 14 the the DT cord-015021-pol2qm74 6468 15 control control NN cord-015021-pol2qm74 6468 16 to to IN cord-015021-pol2qm74 6468 17 11/16 11/16 CD cord-015021-pol2qm74 6468 18 ( ( -LRB- cord-015021-pol2qm74 6468 19 69 69 CD cord-015021-pol2qm74 6468 20 % % NN cord-015021-pol2qm74 6468 21 ) ) -RRB- cord-015021-pol2qm74 6468 22 . . . cord-015021-pol2qm74 6469 1 Conclusion conclusion NN cord-015021-pol2qm74 6469 2 : : : cord-015021-pol2qm74 6470 1 These these DT cord-015021-pol2qm74 6470 2 data datum NNS cord-015021-pol2qm74 6470 3 suggest suggest VBP cord-015021-pol2qm74 6470 4 that that IN cord-015021-pol2qm74 6470 5 haemorrhagic haemorrhagic JJ cord-015021-pol2qm74 6470 6 shock shock NN cord-015021-pol2qm74 6470 7 may may MD cord-015021-pol2qm74 6470 8 lead lead VB cord-015021-pol2qm74 6470 9 to to IN cord-015021-pol2qm74 6470 10 bacterial bacterial JJ cord-015021-pol2qm74 6470 11 translocation translocation NN cord-015021-pol2qm74 6470 12 and/or and/or CC cord-015021-pol2qm74 6470 13 transient transient JJ cord-015021-pol2qm74 6470 14 endotoxemia endotoxemia NN cord-015021-pol2qm74 6470 15 with with IN cord-015021-pol2qm74 6470 16 concomitant concomitant JJ cord-015021-pol2qm74 6470 17 cytokine cytokine NN cord-015021-pol2qm74 6470 18 formation formation NN cord-015021-pol2qm74 6470 19 that that WDT cord-015021-pol2qm74 6470 20 may may MD cord-015021-pol2qm74 6470 21 play play VB cord-015021-pol2qm74 6470 22 an an DT cord-015021-pol2qm74 6470 23 important important JJ cord-015021-pol2qm74 6470 24 role role NN cord-015021-pol2qm74 6470 25 in in IN cord-015021-pol2qm74 6470 26 the the DT cord-015021-pol2qm74 6470 27 pathogenesis pathogenesis NN cord-015021-pol2qm74 6470 28 after after IN cord-015021-pol2qm74 6470 29 shock shock NN cord-015021-pol2qm74 6470 30 and and CC cord-015021-pol2qm74 6470 31 trauma trauma NN cord-015021-pol2qm74 6470 32 , , , cord-015021-pol2qm74 6470 33 rBPI21 rBPI21 NNP cord-015021-pol2qm74 6470 34 might may MD cord-015021-pol2qm74 6470 35 be be VB cord-015021-pol2qm74 6470 36 a a DT cord-015021-pol2qm74 6470 37 useful useful JJ cord-015021-pol2qm74 6470 38 therapeutic therapeutic JJ cord-015021-pol2qm74 6470 39 agent agent NN cord-015021-pol2qm74 6470 40 against against IN cord-015021-pol2qm74 6470 41 endogenous endogenous JJ cord-015021-pol2qm74 6470 42 bacterFal bacterFal NNS cord-015021-pol2qm74 6470 43 / / SYM cord-015021-pol2qm74 6470 44 endotoxin endotoxin NN cord-015021-pol2qm74 6470 45 related relate VBN cord-015021-pol2qm74 6470 46 disorders disorder NNS cord-015021-pol2qm74 6470 47 in in IN cord-015021-pol2qm74 6470 48 hemorrhagic hemorrhagic JJ cord-015021-pol2qm74 6470 49 shock shock NN cord-015021-pol2qm74 6470 50 . . . cord-015021-pol2qm74 6471 1 Morbidity morbidity NN cord-015021-pol2qm74 6471 2 and and CC cord-015021-pol2qm74 6471 3 mortality mortality NN cord-015021-pol2qm74 6471 4 after after IN cord-015021-pol2qm74 6471 5 hypoxia hypoxia NN cord-015021-pol2qm74 6471 6 of of IN cord-015021-pol2qm74 6471 7 the the DT cord-015021-pol2qm74 6471 8 vital vital JJ cord-015021-pol2qm74 6471 9 organs organ NNS cord-015021-pol2qm74 6471 10 had have VBD cord-015021-pol2qm74 6471 11 been be VBN cord-015021-pol2qm74 6471 12 correlated correlate VBN cord-015021-pol2qm74 6471 13 to to IN cord-015021-pol2qm74 6471 14 the the DT cord-015021-pol2qm74 6471 15 production production NN cord-015021-pol2qm74 6471 16 of of IN cord-015021-pol2qm74 6471 17 oxygen oxygen NN cord-015021-pol2qm74 6471 18 radicle radicle NN cord-015021-pol2qm74 6471 19 which which WDT cord-015021-pol2qm74 6471 20 is be VBZ cord-015021-pol2qm74 6471 21 mediated mediate VBN cord-015021-pol2qm74 6471 22 by by IN cord-015021-pol2qm74 6471 23 xanthine xanthine NN cord-015021-pol2qm74 6471 24 oxidase oxidase NN cord-015021-pol2qm74 6471 25 activity activity NN cord-015021-pol2qm74 6471 26 , , , cord-015021-pol2qm74 6471 27 In in IN cord-015021-pol2qm74 6471 28 this this DT cord-015021-pol2qm74 6471 29 study study NN cord-015021-pol2qm74 6471 30 we -PRON- PRP cord-015021-pol2qm74 6471 31 have have VBP cord-015021-pol2qm74 6471 32 evaluated evaluate VBN cord-015021-pol2qm74 6471 33 the the DT cord-015021-pol2qm74 6471 34 survival survival NN cord-015021-pol2qm74 6471 35 rate rate NN cord-015021-pol2qm74 6471 36 after after IN cord-015021-pol2qm74 6471 37 allopurinol allopurinol NN cord-015021-pol2qm74 6471 38 . . . cord-015021-pol2qm74 6472 1 42 42 CD cord-015021-pol2qm74 6472 2 rabbits rabbit NNS cord-015021-pol2qm74 6472 3 weighed weigh VBD cord-015021-pol2qm74 6472 4 900 900 CD cord-015021-pol2qm74 6472 5 + + SYM cord-015021-pol2qm74 6472 6 200 200 CD cord-015021-pol2qm74 6472 7 grams gram NNS cord-015021-pol2qm74 6472 8 divided divide VBN cord-015021-pol2qm74 6472 9 into into IN cord-015021-pol2qm74 6472 10 two two CD cord-015021-pol2qm74 6472 11 groups group NNS cord-015021-pol2qm74 6472 12 . . . cord-015021-pol2qm74 6473 1 Group group NN cord-015021-pol2qm74 6474 1 I -PRON- PRP cord-015021-pol2qm74 6474 2 included include VBD cord-015021-pol2qm74 6474 3 22 22 CD cord-015021-pol2qm74 6474 4 Tabbits tabbit NNS cord-015021-pol2qm74 6474 5 were be VBD cord-015021-pol2qm74 6474 6 treated treat VBN cord-015021-pol2qm74 6474 7 with with IN cord-015021-pol2qm74 6474 8 allopurinol allopurinol NN cord-015021-pol2qm74 6474 9 80 80 CD cord-015021-pol2qm74 6474 10 mg mg NNP cord-015021-pol2qm74 6474 11 / / SYM cord-015021-pol2qm74 6474 12 kg kg NN cord-015021-pol2qm74 6474 13 for for IN cord-015021-pol2qm74 6474 14 seven seven CD cord-015021-pol2qm74 6474 15 days day NNS cord-015021-pol2qm74 6474 16 before before IN cord-015021-pol2qm74 6474 17 induction induction NN cord-015021-pol2qm74 6474 18 of of IN cord-015021-pol2qm74 6474 19 haemorrhage haemorrhage NN cord-015021-pol2qm74 6474 20 . . . cord-015021-pol2qm74 6475 1 Group Group NNP cord-015021-pol2qm74 6475 2 II II NNP cord-015021-pol2qm74 6475 3 as as IN cord-015021-pol2qm74 6475 4 a a DT cord-015021-pol2qm74 6475 5 control control NN cord-015021-pol2qm74 6475 6 included include VBD cord-015021-pol2qm74 6475 7 20 20 CD cord-015021-pol2qm74 6475 8 rabbits rabbit NNS cord-015021-pol2qm74 6475 9 . . . cord-015021-pol2qm74 6476 1 All all DT cord-015021-pol2qm74 6476 2 rabbits rabbit NNS cord-015021-pol2qm74 6476 3 were be VBD cord-015021-pol2qm74 6476 4 subjected subject VBN cord-015021-pol2qm74 6476 5 to to IN cord-015021-pol2qm74 6476 6 25 25 CD cord-015021-pol2qm74 6476 7 % % NN cord-015021-pol2qm74 6476 8 arterial arterial JJ cord-015021-pol2qm74 6476 9 blood blood NN cord-015021-pol2qm74 6476 10 loss loss NN cord-015021-pol2qm74 6476 11 through through IN cord-015021-pol2qm74 6476 12 the the DT cord-015021-pol2qm74 6476 13 central central JJ cord-015021-pol2qm74 6476 14 ear ear NN cord-015021-pol2qm74 6476 15 artery artery NN cord-015021-pol2qm74 6476 16 for for IN cord-015021-pol2qm74 6476 17 one one CD cord-015021-pol2qm74 6476 18 hour hour NN cord-015021-pol2qm74 6477 1 then then RB cord-015021-pol2qm74 6477 2 resusciatation resusciatation NN cord-015021-pol2qm74 6477 3 was be VBD cord-015021-pol2qm74 6477 4 done do VBN cord-015021-pol2qm74 6477 5 by by IN cord-015021-pol2qm74 6477 6 the the DT cord-015021-pol2qm74 6477 7 heparinized heparinize VBN cord-015021-pol2qm74 6477 8 withdrawn withdraw VBN cord-015021-pol2qm74 6477 9 blood blood NN cord-015021-pol2qm74 6477 10 through through IN cord-015021-pol2qm74 6477 11 a a DT cord-015021-pol2qm74 6477 12 marginal marginal JJ cord-015021-pol2qm74 6477 13 ear ear NN cord-015021-pol2qm74 6477 14 vein vein NN cord-015021-pol2qm74 6477 15 . . . cord-015021-pol2qm74 6478 1 During during IN cord-015021-pol2qm74 6478 2 the the DT cord-015021-pol2qm74 6478 3 experiment experiment NN cord-015021-pol2qm74 6478 4 blood blood NN cord-015021-pol2qm74 6478 5 pressure pressure NN cord-015021-pol2qm74 6478 6 and and CC cord-015021-pol2qm74 6478 7 heart heart NN cord-015021-pol2qm74 6478 8 rate rate NN cord-015021-pol2qm74 6478 9 were be VBD cord-015021-pol2qm74 6478 10 monitored monitor VBN cord-015021-pol2qm74 6478 11 through through IN cord-015021-pol2qm74 6478 12 the the DT cord-015021-pol2qm74 6478 13 central central JJ cord-015021-pol2qm74 6478 14 ear ear NN cord-015021-pol2qm74 6478 15 artery artery NN cord-015021-pol2qm74 6478 16 . . . cord-015021-pol2qm74 6479 1 ALso also RB cord-015021-pol2qm74 6479 2 uric uric NN cord-015021-pol2qm74 6479 3 acid acid NN cord-015021-pol2qm74 6479 4 , , , cord-015021-pol2qm74 6479 5 lactic lactic JJ cord-015021-pol2qm74 6479 6 acid acid NN cord-015021-pol2qm74 6479 7 , , , cord-015021-pol2qm74 6479 8 glutathione glutathione NN cord-015021-pol2qm74 6479 9 activity activity NN cord-015021-pol2qm74 6479 10 were be VBD cord-015021-pol2qm74 6479 11 estimated estimate VBN cord-015021-pol2qm74 6479 12 . . . cord-015021-pol2qm74 6480 1 Animal animal NN cord-015021-pol2qm74 6480 2 survival survival NN cord-015021-pol2qm74 6480 3 was be VBD cord-015021-pol2qm74 6480 4 followed follow VBN cord-015021-pol2qm74 6480 5 for for IN cord-015021-pol2qm74 6480 6 10 10 CD cord-015021-pol2qm74 6480 7 days day NNS cord-015021-pol2qm74 6480 8 . . . cord-015021-pol2qm74 6481 1 Postmortem postmortem JJ cord-015021-pol2qm74 6481 2 vital vital JJ cord-015021-pol2qm74 6481 3 organ organ NN cord-015021-pol2qm74 6481 4 histochemistry histochemistry NN cord-015021-pol2qm74 6481 5 and and CC cord-015021-pol2qm74 6481 6 histopathology histopathology NN cord-015021-pol2qm74 6481 7 examinations examination NNS cord-015021-pol2qm74 6481 8 were be VBD cord-015021-pol2qm74 6481 9 done do VBN cord-015021-pol2qm74 6481 10 . . . cord-015021-pol2qm74 6482 1 In in IN cord-015021-pol2qm74 6482 2 group group NN cord-015021-pol2qm74 6482 3 I -PRON- PRP cord-015021-pol2qm74 6482 4 the the DT cord-015021-pol2qm74 6482 5 survival survival NN cord-015021-pol2qm74 6482 6 after after IN cord-015021-pol2qm74 6482 7 three three CD cord-015021-pol2qm74 6482 8 days day NNS cord-015021-pol2qm74 6482 9 was be VBD cord-015021-pol2qm74 6482 10 10 10 CD cord-015021-pol2qm74 6482 11 out out IN cord-015021-pol2qm74 6482 12 of of IN cord-015021-pol2qm74 6482 13 22 22 CD cord-015021-pol2qm74 6482 14 while while NN cord-015021-pol2qm74 6482 15 in in IN cord-015021-pol2qm74 6482 16 group group NN cord-015021-pol2qm74 6482 17 II II NNP cord-015021-pol2qm74 6482 18 it -PRON- PRP cord-015021-pol2qm74 6482 19 was be VBD cord-015021-pol2qm74 6482 20 two two CD cord-015021-pol2qm74 6482 21 out out IN cord-015021-pol2qm74 6482 22 of of IN cord-015021-pol2qm74 6482 23 20 20 CD cord-015021-pol2qm74 6482 24 . . . cord-015021-pol2qm74 6483 1 Our -PRON- PRP$ cord-015021-pol2qm74 6483 2 conc|usion conc|usion NN cord-015021-pol2qm74 6483 3 , , , cord-015021-pol2qm74 6483 4 allopurinol allopurinol NN cord-015021-pol2qm74 6483 5 had have VBD cord-015021-pol2qm74 6483 6 increased increase VBN cord-015021-pol2qm74 6483 7 the the DT cord-015021-pol2qm74 6483 8 survival survival NN cord-015021-pol2qm74 6483 9 in in IN cord-015021-pol2qm74 6483 10 aiiopurinol aiiopurinol NN cord-015021-pol2qm74 6483 11 pretreated pretreate VBN cord-015021-pol2qm74 6483 12 rabbits rabbit NNS cord-015021-pol2qm74 6483 13 which which WDT cord-015021-pol2qm74 6483 14 may may MD cord-015021-pol2qm74 6483 15 indicate indicate VB cord-015021-pol2qm74 6483 16 the the DT cord-015021-pol2qm74 6483 17 value value NN cord-015021-pol2qm74 6483 18 of of IN cord-015021-pol2qm74 6483 19 allopurinol allopurinol NN cord-015021-pol2qm74 6483 20 premedication premedication NN cord-015021-pol2qm74 6483 21 for for IN cord-015021-pol2qm74 6483 22 patient patient NN cord-015021-pol2qm74 6483 23 prepared prepare VBN cord-015021-pol2qm74 6483 24 for for IN cord-015021-pol2qm74 6483 25 elective elective JJ cord-015021-pol2qm74 6483 26 bloody bloody JJ cord-015021-pol2qm74 6483 27 surgical surgical JJ cord-015021-pol2qm74 6483 28 intervention intervention NN cord-015021-pol2qm74 6483 29 . . . cord-015021-pol2qm74 6484 1 H2 H2 NNP cord-015021-pol2qm74 6484 2 receptor receptor NN cord-015021-pol2qm74 6484 3 antagonists antagonist NNS cord-015021-pol2qm74 6484 4 are be VBP cord-015021-pol2qm74 6484 5 commonly commonly RB cord-015021-pol2qm74 6484 6 used use VBN cord-015021-pol2qm74 6484 7 for for IN cord-015021-pol2qm74 6484 8 stress stress NN cord-015021-pol2qm74 6484 9 ulcer ulcer NN cord-015021-pol2qm74 6484 10 prophylaxis prophylaxis NN cord-015021-pol2qm74 6484 11 , , , cord-015021-pol2qm74 6484 12 but but CC cord-015021-pol2qm74 6484 13 their -PRON- PRP$ cord-015021-pol2qm74 6484 14 actions action NNS cord-015021-pol2qm74 6484 15 on on IN cord-015021-pol2qm74 6484 16 the the DT cord-015021-pol2qm74 6484 17 septic septic JJ cord-015021-pol2qm74 6484 18 response response NN cord-015021-pol2qm74 6484 19 are be VBP cord-015021-pol2qm74 6484 20 largely largely RB cord-015021-pol2qm74 6484 21 unknown unknown JJ cord-015021-pol2qm74 6484 22 , , , cord-015021-pol2qm74 6484 23 In in IN cord-015021-pol2qm74 6484 24 an an DT cord-015021-pol2qm74 6484 25 experimental experimental JJ cord-015021-pol2qm74 6484 26 model model NN cord-015021-pol2qm74 6484 27 , , , cord-015021-pol2qm74 6484 28 26 26 CD cord-015021-pol2qm74 6484 29 pigs pig NNS cord-015021-pol2qm74 6484 30 were be VBD cord-015021-pol2qm74 6484 31 first first RB cord-015021-pol2qm74 6484 32 anesthetized anesthetize VBN cord-015021-pol2qm74 6484 33 , , , cord-015021-pol2qm74 6484 34 then then RB cord-015021-pol2qm74 6484 35 injured injure VBN cord-015021-pol2qm74 6484 36 with with IN cord-015021-pol2qm74 6484 37 100 100 CD cord-015021-pol2qm74 6484 38 joules joule NNS cord-015021-pol2qm74 6484 39 of of IN cord-015021-pol2qm74 6484 40 energy energy NN cord-015021-pol2qm74 6484 41 to to IN cord-015021-pol2qm74 6484 42 the the DT cord-015021-pol2qm74 6484 43 posterior posterior JJ cord-015021-pol2qm74 6484 44 thigh thigh NN cord-015021-pol2qm74 6484 45 , , , cord-015021-pol2qm74 6484 46 then then RB cord-015021-pol2qm74 6484 47 hemorrhaged hemorrhage VBD cord-015021-pol2qm74 6484 48 30 30 CD cord-015021-pol2qm74 6484 49 - - SYM cord-015021-pol2qm74 6484 50 40 40 CD cord-015021-pol2qm74 6484 51 % % NN cord-015021-pol2qm74 6484 52 of of IN cord-015021-pol2qm74 6484 53 their -PRON- PRP$ cord-015021-pol2qm74 6484 54 blood blood NN cord-015021-pol2qm74 6484 55 volume volume NN cord-015021-pol2qm74 6484 56 . . . cord-015021-pol2qm74 6485 1 After after IN cord-015021-pol2qm74 6485 2 I -PRON- PRP cord-015021-pol2qm74 6485 3 hr hr NN cord-015021-pol2qm74 6485 4 of of IN cord-015021-pol2qm74 6485 5 shock shock NN cord-015021-pol2qm74 6485 6 , , , cord-015021-pol2qm74 6485 7 all all PDT cord-015021-pol2qm74 6485 8 the the DT cord-015021-pol2qm74 6485 9 shed shed JJ cord-015021-pol2qm74 6485 10 blood blood NN cord-015021-pol2qm74 6485 11 plus plus CC cord-015021-pol2qm74 6485 12 2x 2x NFP cord-015021-pol2qm74 6485 13 the the DT cord-015021-pol2qm74 6485 14 hemorrhage hemorrhage NN cord-015021-pol2qm74 6485 15 volume volume NN cord-015021-pol2qm74 6485 16 as as IN cord-015021-pol2qm74 6485 17 lactated lactate VBN cord-015021-pol2qm74 6485 18 ringers ringer NNS cord-015021-pol2qm74 6485 19 was be VBD cord-015021-pol2qm74 6485 20 infused infuse VBN cord-015021-pol2qm74 6485 21 . . . cord-015021-pol2qm74 6486 1 Following follow VBG cord-015021-pol2qm74 6486 2 resuscitation resuscitation NN cord-015021-pol2qm74 6486 3 , , , cord-015021-pol2qm74 6486 4 ranitidine ranitidine NN cord-015021-pol2qm74 6486 5 ( ( -LRB- cord-015021-pol2qm74 6486 6 1.5 1.5 CD cord-015021-pol2qm74 6486 7 mg mg NNP cord-015021-pol2qm74 6486 8 / / SYM cord-015021-pol2qm74 6486 9 kg kg NNP cord-015021-pol2qm74 6486 10 iv iv CD cord-015021-pol2qm74 6486 11 twice twice RB cord-015021-pol2qm74 6486 12 daily daily JJ cord-015021-pol2qm74 6486 13 ) ) -RRB- cord-015021-pol2qm74 6486 14 or or CC cord-015021-pol2qm74 6486 15 saline saline NN cord-015021-pol2qm74 6486 16 placebo placebo NN cord-015021-pol2qm74 6486 17 was be VBD cord-015021-pol2qm74 6486 18 begun begin VBN cord-015021-pol2qm74 6486 19 . . . cord-015021-pol2qm74 6487 1 The the DT cord-015021-pol2qm74 6487 2 treatment treatment NN cord-015021-pol2qm74 6487 3 group group NN cord-015021-pol2qm74 6487 4 was be VBD cord-015021-pol2qm74 6487 5 randomly randomly RB cord-015021-pol2qm74 6487 6 assigned assign VBN cord-015021-pol2qm74 6487 7 in in IN cord-015021-pol2qm74 6487 8 a a DT cord-015021-pol2qm74 6487 9 blinded blinded JJ cord-015021-pol2qm74 6487 10 fashion fashion NN cord-015021-pol2qm74 6487 11 . . . cord-015021-pol2qm74 6488 1 After after IN cord-015021-pol2qm74 6488 2 72 72 CD cord-015021-pol2qm74 6488 3 hrs hrs NN cord-015021-pol2qm74 6488 4 , , , cord-015021-pol2qm74 6488 5 a a DT cord-015021-pol2qm74 6488 6 septic septic JJ cord-015021-pol2qm74 6488 7 challenge challenge NN cord-015021-pol2qm74 6488 8 was be VBD cord-015021-pol2qm74 6488 9 administered administer VBN cord-015021-pol2qm74 6488 10 ( ( -LRB- cord-015021-pol2qm74 6488 11 15 15 CD cord-015021-pol2qm74 6488 12 Bg Bg NNP cord-015021-pol2qm74 6488 13 / / SYM cord-015021-pol2qm74 6488 14 kg kg NNP cord-015021-pol2qm74 6488 15 of of IN cord-015021-pol2qm74 6488 16 E. E. NNP cord-015021-pol2qm74 6488 17 coil coil NN cord-015021-pol2qm74 6488 18 endotoxin endotoxin NN cord-015021-pol2qm74 6488 19 ( ( -LRB- cord-015021-pol2qm74 6488 20 LPS LPS NNP cord-015021-pol2qm74 6488 21 ) ) -RRB- cord-015021-pol2qm74 6488 22 ) ) -RRB- cord-015021-pol2qm74 6488 23 . . . cord-015021-pol2qm74 6489 1 Serial serial JJ cord-015021-pol2qm74 6489 2 gastroscopy gastroscopy NN cord-015021-pol2qm74 6489 3 , , , cord-015021-pol2qm74 6489 4 gastric gastric JJ cord-015021-pol2qm74 6489 5 pH ph NN cord-015021-pol2qm74 6489 6 , , , cord-015021-pol2qm74 6489 7 hemodynamics hemodynamic NNS cord-015021-pol2qm74 6489 8 , , , cord-015021-pol2qm74 6489 9 ABG ABG NNP cord-015021-pol2qm74 6489 10 's 's POS cord-015021-pol2qm74 6489 11 , , , cord-015021-pol2qm74 6489 12 physiologic physiologic JJ cord-015021-pol2qm74 6489 13 dead dead JJ cord-015021-pol2qm74 6489 14 space space NN cord-015021-pol2qm74 6489 15 ventilation ventilation NN cord-015021-pol2qm74 6489 16 , , , cord-015021-pol2qm74 6489 17 leukocyte leukocyte NN cord-015021-pol2qm74 6489 18 counts count VBZ cord-015021-pol2qm74 6489 19 , , , cord-015021-pol2qm74 6489 20 and and CC cord-015021-pol2qm74 6489 21 tumor tumor NN cord-015021-pol2qm74 6489 22 necrosis necrosis NN cord-015021-pol2qm74 6489 23 factor factor NN cord-015021-pol2qm74 6489 24 ( ( -LRB- cord-015021-pol2qm74 6489 25 TNF TNF NNP cord-015021-pol2qm74 6489 26 ) ) -RRB- cord-015021-pol2qm74 6489 27 levels level NNS cord-015021-pol2qm74 6489 28 were be VBD cord-015021-pol2qm74 6489 29 recorded record VBN cord-015021-pol2qm74 6489 30 for for IN cord-015021-pol2qm74 6489 31 180 180 CD cord-015021-pol2qm74 6489 32 min min NN cord-015021-pol2qm74 6489 33 . . . cord-015021-pol2qm74 6490 1 Baseline baseline JJ cord-015021-pol2qm74 6490 2 values value NNS cord-015021-pol2qm74 6490 3 and and CC cord-015021-pol2qm74 6490 4 units unit NNS cord-015021-pol2qm74 6490 5 were be VBD cord-015021-pol2qm74 6490 6 cardiac cardiac JJ cord-015021-pol2qm74 6490 7 index index NN cord-015021-pol2qm74 6490 8 102 102 CD cord-015021-pol2qm74 6490 9 _ _ NN cord-015021-pol2qm74 6491 1 + + CC cord-015021-pol2qm74 6492 1 9 9 CD cord-015021-pol2qm74 6492 2 ml ml NN cord-015021-pol2qm74 6492 3 / / SYM cord-015021-pol2qm74 6492 4 min min NN cord-015021-pol2qm74 6492 5 / / SYM cord-015021-pol2qm74 6492 6 kg kg NNP cord-015021-pol2qm74 6492 7 ( ( -LRB- cord-015021-pol2qm74 6492 8 CI CI NNP cord-015021-pol2qm74 6492 9 ) ) -RRB- cord-015021-pol2qm74 6492 10 , , , cord-015021-pol2qm74 6492 11 arterial arterial JJ cord-015021-pol2qm74 6492 12 PO2 PO2 NNP cord-015021-pol2qm74 6492 13 228 228 CD cord-015021-pol2qm74 6492 14 + + SYM cord-015021-pol2qm74 6492 15 11 11 CD cord-015021-pol2qm74 6492 16 mmHg(PaO2 mmHg(PaO2 NNP cord-015021-pol2qm74 6492 17 ) ) -RRB- cord-015021-pol2qm74 6492 18 , , , cord-015021-pol2qm74 6492 19 base base NN cord-015021-pol2qm74 6492 20 excess excess JJ cord-015021-pol2qm74 6492 21 6.5 6.5 CD cord-015021-pol2qm74 6492 22 -+ -+ SYM cord-015021-pol2qm74 6492 23 1 1 CD cord-015021-pol2qm74 6492 24 meq meq NN cord-015021-pol2qm74 6492 25 ( ( -LRB- cord-015021-pol2qm74 6492 26 BE BE NNP cord-015021-pol2qm74 6492 27 ) ) -RRB- cord-015021-pol2qm74 6492 28 , , , cord-015021-pol2qm74 6492 29 physiologic physiologic JJ cord-015021-pol2qm74 6492 30 dead dead JJ cord-015021-pol2qm74 6492 31 space space NN cord-015021-pol2qm74 6492 32 fraction fraction NN cord-015021-pol2qm74 6492 33 23 23 CD cord-015021-pol2qm74 6493 1 + + CC cord-015021-pol2qm74 6493 2 _ _ NN cord-015021-pol2qm74 6493 3 4 4 CD cord-015021-pol2qm74 6493 4 % % NN cord-015021-pol2qm74 6493 5 ( ( -LRB- cord-015021-pol2qm74 6493 6 PDS PDS NNP cord-015021-pol2qm74 6493 7 ) ) -RRB- cord-015021-pol2qm74 6493 8 , , , cord-015021-pol2qm74 6493 9 and and CC cord-015021-pol2qm74 6493 10 TNF TNF NNP cord-015021-pol2qm74 6493 11 0.4 0.4 CD cord-015021-pol2qm74 6493 12 + + SYM cord-015021-pol2qm74 6493 13 0.1 0.1 CD cord-015021-pol2qm74 6493 14 units unit NNS cord-015021-pol2qm74 6493 15 / / SYM cord-015021-pol2qm74 6493 16 ml ml NN cord-015021-pol2qm74 6493 17 . . . cord-015021-pol2qm74 6494 1 Baseline baseline JJ cord-015021-pol2qm74 6494 2 gastric gastric JJ cord-015021-pol2qm74 6494 3 pH ph NN cord-015021-pol2qm74 6494 4 was be VBD cord-015021-pol2qm74 6494 5 3.9 3.9 CD cord-015021-pol2qm74 6494 6 -+ -+ . cord-015021-pol2qm74 6494 7 0.4 0.4 CD cord-015021-pol2qm74 6494 8 and and CC cord-015021-pol2qm74 6495 1 4.8 4.8 CD cord-015021-pol2qm74 6495 2 _ _ NN cord-015021-pol2qm74 6495 3 + + SYM cord-015021-pol2qm74 6495 4 0.5 0.5 CD cord-015021-pol2qm74 6495 5 in in IN cord-015021-pol2qm74 6495 6 the the DT cord-015021-pol2qm74 6495 7 placebo placebo NN cord-015021-pol2qm74 6495 8 and and CC cord-015021-pol2qm74 6495 9 ranitidine ranitidine NN cord-015021-pol2qm74 6495 10 groups group NNS cord-015021-pol2qm74 6495 11 , , , cord-015021-pol2qm74 6495 12 respectively respectively RB cord-015021-pol2qm74 6495 13 . . . cord-015021-pol2qm74 6496 1 The the DT cord-015021-pol2qm74 6496 2 gastritis gastritis NN cord-015021-pol2qm74 6496 3 following follow VBG cord-015021-pol2qm74 6496 4 hemorrhage hemorrhage NN cord-015021-pol2qm74 6496 5 was be VBD cord-015021-pol2qm74 6496 6 marginally marginally RB cord-015021-pol2qm74 6496 7 attenuated attenuated JJ cord-015021-pol2qm74 6496 8 in in IN cord-015021-pol2qm74 6496 9 the the DT cord-015021-pol2qm74 6496 10 ranitidine ranitidine NN cord-015021-pol2qm74 6496 11 group group NN cord-015021-pol2qm74 6496 12 . . . cord-015021-pol2qm74 6497 1 Following follow VBG cord-015021-pol2qm74 6497 2 LPS LPS NNP cord-015021-pol2qm74 6497 3 infusion infusion NN cord-015021-pol2qm74 6497 4 the the DT cord-015021-pol2qm74 6497 5 following follow VBG cord-015021-pol2qm74 6497 6 were be VBD cord-015021-pol2qm74 6497 7 obtained obtain VBN cord-015021-pol2qm74 6497 8 : : : cord-015021-pol2qm74 6497 9 CI CI NNP cord-015021-pol2qm74 6497 10 PaO2 PaO2 NNS cord-015021-pol2qm74 6498 1 * * NFP cord-015021-pol2qm74 6498 2 BE be VB cord-015021-pol2qm74 6498 3 * * NFP cord-015021-pol2qm74 6499 1 Gastric gastric JJ cord-015021-pol2qm74 6500 1 * * NFP cord-015021-pol2qm74 6500 2 PDS PDS NNP cord-015021-pol2qm74 6501 1 * * NFP cord-015021-pol2qm74 6502 1 Peak Peak NNP cord-015021-pol2qm74 6502 2 * * NFP cord-015021-pol2qm74 6502 3 120 120 CD cord-015021-pol2qm74 6502 4 rain rain VBP cord-015021-pol2qm74 6502 5 60 60 CD cord-015021-pol2qm74 6502 6 rain rain NN cord-015021-pol2qm74 6502 7 120 120 CD cord-015021-pol2qm74 6502 8 rain rain NN cord-015021-pol2qm74 6503 1 pH pH NNP cord-015021-pol2qm74 6504 1 120 120 CD cord-015021-pol2qm74 6504 2 min min NNP cord-015021-pol2qm74 6504 3 TNF TNF NNP cord-015021-pol2qm74 6504 4 Ranitidine Ranitidine NNP cord-015021-pol2qm74 6504 5 167_+17 167_+17 NNP cord-015021-pol2qm74 6504 6 118_+15 118_+15 CD cord-015021-pol2qm74 6504 7 -4.4±1 -4.4±1 NNP cord-015021-pol2qm74 6504 8 . . . cord-015021-pol2qm74 6505 1 Bum bum JJ cord-015021-pol2qm74 6505 2 injury injury NN cord-015021-pol2qm74 6505 3 results result NNS cord-015021-pol2qm74 6505 4 in in IN cord-015021-pol2qm74 6505 5 hypermetabolism hypermetabolism NN cord-015021-pol2qm74 6505 6 , , , cord-015021-pol2qm74 6505 7 fever fever NN cord-015021-pol2qm74 6505 8 and and CC cord-015021-pol2qm74 6505 9 nitrogen nitrogen NN cord-015021-pol2qm74 6505 10 wasting wasting NN cord-015021-pol2qm74 6505 11 . . . cord-015021-pol2qm74 6506 1 Endotoxin endotoxin NN cord-015021-pol2qm74 6506 2 ( ( -LRB- cord-015021-pol2qm74 6506 3 LPS LPS NNP cord-015021-pol2qm74 6506 4 ) ) -RRB- cord-015021-pol2qm74 6506 5 has have VBZ cord-015021-pol2qm74 6506 6 been be VBN cord-015021-pol2qm74 6506 7 proposed propose VBN cord-015021-pol2qm74 6506 8 to to TO cord-015021-pol2qm74 6506 9 mediate mediate VB cord-015021-pol2qm74 6506 10 these these DT cord-015021-pol2qm74 6506 11 effects effect NNS cord-015021-pol2qm74 6506 12 , , , cord-015021-pol2qm74 6506 13 either either CC cord-015021-pol2qm74 6506 14 directly directly RB cord-015021-pol2qm74 6506 15 or or CC cord-015021-pol2qm74 6506 16 via via IN cord-015021-pol2qm74 6506 17 activation activation NN cord-015021-pol2qm74 6506 18 of of IN cord-015021-pol2qm74 6506 19 macrophages macrophage NNS cord-015021-pol2qm74 6506 20 to to TO cord-015021-pol2qm74 6506 21 produce produce VB cord-015021-pol2qm74 6506 22 cytokines cytokine NNS cord-015021-pol2qm74 6506 23 such such JJ cord-015021-pol2qm74 6506 24 as as IN cord-015021-pol2qm74 6506 25 interleukin-6 interleukin-6 NNP cord-015021-pol2qm74 6506 26 ( ( -LRB- cord-015021-pol2qm74 6506 27 II-6 II-6 NNP cord-015021-pol2qm74 6506 28 ) ) -RRB- cord-015021-pol2qm74 6506 29 . . . cord-015021-pol2qm74 6507 1 This this DT cord-015021-pol2qm74 6507 2 study study NN cord-015021-pol2qm74 6507 3 was be VBD cord-015021-pol2qm74 6507 4 designed design VBN cord-015021-pol2qm74 6507 5 to to TO cord-015021-pol2qm74 6507 6 clarify clarify VB cord-015021-pol2qm74 6507 7 the the DT cord-015021-pol2qm74 6507 8 role role NN cord-015021-pol2qm74 6507 9 of of IN cord-015021-pol2qm74 6507 10 LPS LPS NNP cord-015021-pol2qm74 6507 11 and and CC cord-015021-pol2qm74 6507 12 11 11 CD cord-015021-pol2qm74 6507 13 - - SYM cord-015021-pol2qm74 6507 14 6 6 CD cord-015021-pol2qm74 6507 15 in in IN cord-015021-pol2qm74 6507 16 the the DT cord-015021-pol2qm74 6507 17 metabolic metabolic JJ cord-015021-pol2qm74 6507 18 response response NN cord-015021-pol2qm74 6507 19 to to TO cord-015021-pol2qm74 6507 20 bum bum VB cord-015021-pol2qm74 6507 21 injury injury NN cord-015021-pol2qm74 6507 22 . . . cord-015021-pol2qm74 6508 1 Twenty twenty CD cord-015021-pol2qm74 6508 2 - - HYPH cord-015021-pol2qm74 6508 3 five five CD cord-015021-pol2qm74 6508 4 burn burn NN cord-015021-pol2qm74 6508 5 patients patient NNS cord-015021-pol2qm74 6508 6 ( ( -LRB- cord-015021-pol2qm74 6508 7 49 49 CD cord-015021-pol2qm74 6508 8 -+ -+ SYM cord-015021-pol2qm74 6508 9 17 17 CD cord-015021-pol2qm74 6508 10 % % NN cord-015021-pol2qm74 6508 11 ; ; : cord-015021-pol2qm74 6508 12 16 16 CD cord-015021-pol2qm74 6508 13 + + SYM cord-015021-pol2qm74 6508 14 15 15 CD cord-015021-pol2qm74 6508 15 % % NN cord-015021-pol2qm74 6508 16 FT FT NNP cord-015021-pol2qm74 6508 17 BSA BSA NNP cord-015021-pol2qm74 6508 18 burn burn NN cord-015021-pol2qm74 6508 19 ; ; . cord-015021-pol2qm74 6509 1 32 32 CD cord-015021-pol2qm74 6509 2 _ _ NN cord-015021-pol2qm74 6509 3 + + SYM cord-015021-pol2qm74 6509 4 16 16 CD cord-015021-pol2qm74 6509 5 years year NNS cord-015021-pol2qm74 6509 6 old old JJ cord-015021-pol2qm74 6509 7 ) ) -RRB- cord-015021-pol2qm74 6509 8 were be VBD cord-015021-pol2qm74 6509 9 studied study VBN cord-015021-pol2qm74 6509 10 serially serially RB cord-015021-pol2qm74 6509 11 for for IN cord-015021-pol2qm74 6509 12 three three CD cord-015021-pol2qm74 6509 13 weeks week NNS cord-015021-pol2qm74 6509 14 post post NN cord-015021-pol2qm74 6509 15 bum bum NN cord-015021-pol2qm74 6509 16 . . . cord-015021-pol2qm74 6510 1 Patients patient NNS cord-015021-pol2qm74 6510 2 underwent undergo VBD cord-015021-pol2qm74 6510 3 partitional partitional JJ cord-015021-pol2qm74 6510 4 calorimetry calorimetry NN cord-015021-pol2qm74 6510 5 to to TO cord-015021-pol2qm74 6510 6 assess assess VB cord-015021-pol2qm74 6510 7 metabolic metabolic JJ cord-015021-pol2qm74 6510 8 rate rate NN cord-015021-pol2qm74 6510 9 and and CC cord-015021-pol2qm74 6510 10 compartmented compartmented JJ cord-015021-pol2qm74 6510 11 heat heat NN cord-015021-pol2qm74 6510 12 loss loss NN cord-015021-pol2qm74 6510 13 . . . cord-015021-pol2qm74 6511 1 Nitrogen nitrogen NN cord-015021-pol2qm74 6511 2 was be VBD cord-015021-pol2qm74 6511 3 assayed assay VBN cord-015021-pol2qm74 6511 4 using use VBG cord-015021-pol2qm74 6511 5 chemiluminescence chemiluminescence NN cord-015021-pol2qm74 6511 6 . . . cord-015021-pol2qm74 6512 1 LPS LPS NNP cord-015021-pol2qm74 6512 2 and and CC cord-015021-pol2qm74 6512 3 I1 I1 NNP cord-015021-pol2qm74 6512 4 - - HYPH cord-015021-pol2qm74 6512 5 6 6 CD cord-015021-pol2qm74 6512 6 were be VBD cord-015021-pol2qm74 6512 7 measured measure VBN cord-015021-pol2qm74 6512 8 with with IN cord-015021-pol2qm74 6512 9 Limulus Limulus NNP cord-015021-pol2qm74 6512 10 Amebocyte Amebocyte NNP cord-015021-pol2qm74 6512 11 Lysate Lysate NNP cord-015021-pol2qm74 6512 12 assay assay NN cord-015021-pol2qm74 6512 13 and and CC cord-015021-pol2qm74 6512 14 ELISA ELISA NNP cord-015021-pol2qm74 6512 15 . . . cord-015021-pol2qm74 6513 1 Patients patient NNS cord-015021-pol2qm74 6513 2 were be VBD cord-015021-pol2qm74 6513 3 excluded exclude VBN cord-015021-pol2qm74 6513 4 if if IN cord-015021-pol2qm74 6513 5 they -PRON- PRP cord-015021-pol2qm74 6513 6 suffered suffer VBD cord-015021-pol2qm74 6513 7 smoke smoke NN cord-015021-pol2qm74 6513 8 inhalation inhalation NN cord-015021-pol2qm74 6513 9 , , , cord-015021-pol2qm74 6513 10 showed show VBD cord-015021-pol2qm74 6513 11 any any DT cord-015021-pol2qm74 6513 12 sign sign NN cord-015021-pol2qm74 6513 13 of of IN cord-015021-pol2qm74 6513 14 sepsis sepsis NN cord-015021-pol2qm74 6513 15 or or CC cord-015021-pol2qm74 6513 16 failed fail VBD cord-015021-pol2qm74 6513 17 to to TO cord-015021-pol2qm74 6513 18 rapidly rapidly RB cord-015021-pol2qm74 6513 19 meet meet VB cord-015021-pol2qm74 6513 20 their -PRON- PRP$ cord-015021-pol2qm74 6513 21 nutritional nutritional JJ cord-015021-pol2qm74 6513 22 needs need NNS cord-015021-pol2qm74 6513 23 via via IN cord-015021-pol2qm74 6513 24 the the DT cord-015021-pol2qm74 6513 25 enteral enteral JJ cord-015021-pol2qm74 6513 26 route route NN cord-015021-pol2qm74 6513 27 . . . cord-015021-pol2qm74 6514 1 Ten ten CD cord-015021-pol2qm74 6514 2 patients patient NNS cord-015021-pol2qm74 6514 3 received receive VBD cord-015021-pol2qm74 6514 4 intravenous intravenous JJ cord-015021-pol2qm74 6514 5 Polymixin Polymixin NNP cord-015021-pol2qm74 6514 6 B B NNP cord-015021-pol2qm74 6514 7 ( ( -LRB- cord-015021-pol2qm74 6514 8 5,000 5,000 CD cord-015021-pol2qm74 6514 9 U U NNP cord-015021-pol2qm74 6514 10 / / SYM cord-015021-pol2qm74 6514 11 kg kg NN cord-015021-pol2qm74 6514 12 / / SYM cord-015021-pol2qm74 6514 13 day day NN cord-015021-pol2qm74 6514 14 to to TO cord-015021-pol2qm74 6514 15 bind bind VB cord-015021-pol2qm74 6514 16 LPS LPS NNP cord-015021-pol2qm74 6514 17 ) ) -RRB- cord-015021-pol2qm74 6514 18 . . . cord-015021-pol2qm74 6515 1 These these DT cord-015021-pol2qm74 6515 2 patients patient NNS cord-015021-pol2qm74 6515 3 did do VBD cord-015021-pol2qm74 6515 4 not not RB cord-015021-pol2qm74 6515 5 differ differ VB cord-015021-pol2qm74 6515 6 for for IN cord-015021-pol2qm74 6515 7 the the DT cord-015021-pol2qm74 6515 8 remainder remainder NN cord-015021-pol2qm74 6515 9 . . . cord-015021-pol2qm74 6516 1 All all DT cord-015021-pol2qm74 6516 2 patients patient NNS cord-015021-pol2qm74 6516 3 were be VBD cord-015021-pol2qm74 6516 4 hypermetabolic hypermetabolic JJ cord-015021-pol2qm74 6516 5 and and CC cord-015021-pol2qm74 6516 6 febrile febrile JJ cord-015021-pol2qm74 6516 7 in in IN cord-015021-pol2qm74 6516 8 proportion proportion NN cord-015021-pol2qm74 6516 9 to to IN cord-015021-pol2qm74 6516 10 the the DT cord-015021-pol2qm74 6516 11 size size NN cord-015021-pol2qm74 6516 12 of of IN cord-015021-pol2qm74 6516 13 their -PRON- PRP$ cord-015021-pol2qm74 6516 14 bum bum NN cord-015021-pol2qm74 6516 15 wound wound NN cord-015021-pol2qm74 6516 16 but but CC cord-015021-pol2qm74 6516 17 were be VBD cord-015021-pol2qm74 6516 18 not not RB cord-015021-pol2qm74 6516 19 endotoxemic endotoxemic JJ cord-015021-pol2qm74 6516 20 ( ( -LRB- cord-015021-pol2qm74 6516 21 3.1 3.1 CD cord-015021-pol2qm74 6516 22 + + CC cord-015021-pol2qm74 6516 23 _ _ NN cord-015021-pol2qm74 6516 24 5.6 5.6 CD cord-015021-pol2qm74 6516 25 pg pg NNP cord-015021-pol2qm74 6516 26 / / SYM cord-015021-pol2qm74 6516 27 ml ml NN cord-015021-pol2qm74 6516 28 ; ; : cord-015021-pol2qm74 6516 29 normal normal JJ cord-015021-pol2qm74 6516 30 < < XX cord-015021-pol2qm74 6516 31 40 40 CD cord-015021-pol2qm74 6516 32 pg pg NN cord-015021-pol2qm74 6516 33 / / SYM cord-015021-pol2qm74 6516 34 ml ml NN cord-015021-pol2qm74 6516 35 ) ) -RRB- cord-015021-pol2qm74 6516 36 . . . cord-015021-pol2qm74 6517 1 I1 I1 NNP cord-015021-pol2qm74 6517 2 - - HYPH cord-015021-pol2qm74 6517 3 6 6 NNP cord-015021-pol2qm74 6517 4 did do VBD cord-015021-pol2qm74 6517 5 demonstrate demonstrate VB cord-015021-pol2qm74 6517 6 a a DT cord-015021-pol2qm74 6517 7 significant significant JJ cord-015021-pol2qm74 6517 8 correlation correlation NN cord-015021-pol2qm74 6517 9 with with IN cord-015021-pol2qm74 6517 10 cole cole NNP cord-015021-pol2qm74 6517 11 temperature temperature NN cord-015021-pol2qm74 6517 12 ( ( -LRB- cord-015021-pol2qm74 6517 13 Tr~ tr~ NN cord-015021-pol2qm74 6517 14 = = NFP cord-015021-pol2qm74 6518 1 37.6 37.6 CD cord-015021-pol2qm74 6518 2 + + SYM cord-015021-pol2qm74 6518 3 0.21ogi1 0.21ogi1 CD cord-015021-pol2qm74 6518 4 - - SYM cord-015021-pol2qm74 6518 5 6 6 CD cord-015021-pol2qm74 6518 6 , , , cord-015021-pol2qm74 6518 7 P=0.04 P=0.04 NNP cord-015021-pol2qm74 6518 8 ) ) -RRB- cord-015021-pol2qm74 6518 9 and and CC cord-015021-pol2qm74 6518 10 with with IN cord-015021-pol2qm74 6518 11 nitrogen nitrogen NN cord-015021-pol2qm74 6518 12 excretion excretion NN cord-015021-pol2qm74 6518 13 ( ( -LRB- cord-015021-pol2qm74 6518 14 Nou Nou NNP cord-015021-pol2qm74 6518 15 t t NNP cord-015021-pol2qm74 6518 16 = = SYM cord-015021-pol2qm74 6518 17 -5.2 -5.2 NNP cord-015021-pol2qm74 6518 18 4 4 CD cord-015021-pol2qm74 6518 19 - - HYPH cord-015021-pol2qm74 6518 20 0.091ogi1 0.091ogi1 CD cord-015021-pol2qm74 6518 21 - - HYPH cord-015021-pol2qm74 6518 22 6 6 CD cord-015021-pol2qm74 6518 23 + + SYM cord-015021-pol2qm74 6518 24 0.14TR 0.14tr CD cord-015021-pol2qm74 6518 25 , , , cord-015021-pol2qm74 6518 26 P=0.01 P=0.01 '' cord-015021-pol2qm74 6518 27 ) ) -RRB- cord-015021-pol2qm74 6518 28 . . . cord-015021-pol2qm74 6519 1 Administration Administration NNP cord-015021-pol2qm74 6519 2 of of IN cord-015021-pol2qm74 6519 3 polymixin polymixin NNP cord-015021-pol2qm74 6519 4 B B NNP cord-015021-pol2qm74 6519 5 had have VBD cord-015021-pol2qm74 6519 6 no no DT cord-015021-pol2qm74 6519 7 effect effect NN cord-015021-pol2qm74 6519 8 on on IN cord-015021-pol2qm74 6519 9 metabolic metabolic JJ cord-015021-pol2qm74 6519 10 rate rate NN cord-015021-pol2qm74 6519 11 , , , cord-015021-pol2qm74 6519 12 temperature temperature NN cord-015021-pol2qm74 6519 13 or or CC cord-015021-pol2qm74 6519 14 I1 i1 NN cord-015021-pol2qm74 6519 15 - - HYPH cord-015021-pol2qm74 6519 16 6 6 CD cord-015021-pol2qm74 6519 17 levels level NNS cord-015021-pol2qm74 6519 18 but but CC cord-015021-pol2qm74 6519 19 did do VBD cord-015021-pol2qm74 6519 20 reduce reduce VB cord-015021-pol2qm74 6519 21 nitrogen nitrogen NN cord-015021-pol2qm74 6519 22 excretion excretion NN cord-015021-pol2qm74 6519 23 resulting result VBG cord-015021-pol2qm74 6519 24 in in IN cord-015021-pol2qm74 6519 25 more more RBR cord-015021-pol2qm74 6519 26 positive positive JJ cord-015021-pol2qm74 6519 27 nitrogen nitrogen NN cord-015021-pol2qm74 6519 28 balance balance NN cord-015021-pol2qm74 6519 29 ( ( -LRB- cord-015021-pol2qm74 6519 30 0.t 0.t CD cord-015021-pol2qm74 6519 31 grn grn NNP cord-015021-pol2qm74 6519 32 / / SYM cord-015021-pol2qm74 6519 33 day day NN cord-015021-pol2qm74 6519 34 vs. vs. FW cord-015021-pol2qm74 6519 35 -0.1 -0.1 CD cord-015021-pol2qm74 6519 36 gm gm NNP cord-015021-pol2qm74 6519 37 / / SYM cord-015021-pol2qm74 6519 38 day day NN cord-015021-pol2qm74 6519 39 , , , cord-015021-pol2qm74 6519 40 P=0.04 P=0.04 NNP cord-015021-pol2qm74 6519 41 ) ) -RRB- cord-015021-pol2qm74 6519 42 . . . cord-015021-pol2qm74 6520 1 Although although IN cord-015021-pol2qm74 6520 2 bum bum JJ cord-015021-pol2qm74 6520 3 injury injury NN cord-015021-pol2qm74 6520 4 does do VBZ cord-015021-pol2qm74 6520 5 not not RB cord-015021-pol2qm74 6520 6 produce produce VB cord-015021-pol2qm74 6520 7 an an DT cord-015021-pol2qm74 6520 8 obligatory obligatory JJ cord-015021-pol2qm74 6520 9 endotoxemia endotoxemia NN cord-015021-pol2qm74 6520 10 , , , cord-015021-pol2qm74 6520 11 I1 i1 NN cord-015021-pol2qm74 6520 12 - - HYPH cord-015021-pol2qm74 6520 13 6 6 NNP cord-015021-pol2qm74 6520 14 does do VBZ cord-015021-pol2qm74 6520 15 appear appear VB cord-015021-pol2qm74 6520 16 to to TO cord-015021-pol2qm74 6520 17 play play VB cord-015021-pol2qm74 6520 18 a a DT cord-015021-pol2qm74 6520 19 role role NN cord-015021-pol2qm74 6520 20 in in IN cord-015021-pol2qm74 6520 21 the the DT cord-015021-pol2qm74 6520 22 fever fever NN cord-015021-pol2qm74 6520 23 and and CC cord-015021-pol2qm74 6520 24 nitrogen nitrogen NN cord-015021-pol2qm74 6520 25 wasting wasting NN cord-015021-pol2qm74 6520 26 seen see VBN cord-015021-pol2qm74 6520 27 with with IN cord-015021-pol2qm74 6520 28 such such JJ cord-015021-pol2qm74 6520 29 injuries injury NNS cord-015021-pol2qm74 6520 30 . . . cord-015021-pol2qm74 6521 1 The the DT cord-015021-pol2qm74 6521 2 effect effect NN cord-015021-pol2qm74 6521 3 ofPolymixin ofPolymixin NNP cord-015021-pol2qm74 6521 4 B B NNP cord-015021-pol2qm74 6521 5 on on IN cord-015021-pol2qm74 6521 6 nitrogen nitrogen NN cord-015021-pol2qm74 6521 7 excretion excretion NN cord-015021-pol2qm74 6521 8 suggests suggest VBZ cord-015021-pol2qm74 6521 9 that that IN cord-015021-pol2qm74 6521 10 LPS LPS NNP cord-015021-pol2qm74 6521 11 may may MD cord-015021-pol2qm74 6521 12 play play VB cord-015021-pol2qm74 6521 13 a a DT cord-015021-pol2qm74 6521 14 role role NN cord-015021-pol2qm74 6521 15 either either CC cord-015021-pol2qm74 6521 16 locally locally RB cord-015021-pol2qm74 6521 17 or or CC cord-015021-pol2qm74 6521 18 in in IN cord-015021-pol2qm74 6521 19 the the DT cord-015021-pol2qm74 6521 20 portal portal JJ cord-015021-pol2qm74 6521 21 system system NN cord-015021-pol2qm74 6521 22 . . . cord-015021-pol2qm74 6522 1 Introduction introduction NN cord-015021-pol2qm74 6522 2 : : : cord-015021-pol2qm74 6523 1 There there EX cord-015021-pol2qm74 6523 2 is be VBZ cord-015021-pol2qm74 6523 3 substantial substantial JJ cord-015021-pol2qm74 6523 4 evidence evidence NN cord-015021-pol2qm74 6523 5 that that WDT cord-015021-pol2qm74 6523 6 release release NN cord-015021-pol2qm74 6523 7 of of IN cord-015021-pol2qm74 6523 8 inflammatory inflammatory JJ cord-015021-pol2qm74 6523 9 mediators mediator NNS cord-015021-pol2qm74 6523 10 by by IN cord-015021-pol2qm74 6523 11 activated activate VBN cord-015021-pol2qm74 6523 12 Kupffer Kupffer NNP cord-015021-pol2qm74 6523 13 cells cell NNS cord-015021-pol2qm74 6523 14 contribute contribute VBP cord-015021-pol2qm74 6523 15 to to IN cord-015021-pol2qm74 6523 16 the the DT cord-015021-pol2qm74 6523 17 course course NN cord-015021-pol2qm74 6523 18 of of IN cord-015021-pol2qm74 6523 19 a a DT cord-015021-pol2qm74 6523 20 systemic systemic JJ cord-015021-pol2qm74 6523 21 inflammatory inflammatory JJ cord-015021-pol2qm74 6523 22 process process NN cord-015021-pol2qm74 6523 23 , , , cord-015021-pol2qm74 6523 24 e.g. e.g. RB cord-015021-pol2qm74 6523 25 after after IN cord-015021-pol2qm74 6523 26 shock shock NN cord-015021-pol2qm74 6523 27 or or CC cord-015021-pol2qm74 6523 28 lrauma lrauma NN cord-015021-pol2qm74 6523 29 . . . cord-015021-pol2qm74 6524 1 Besides besides IN cord-015021-pol2qm74 6524 2 the the DT cord-015021-pol2qm74 6524 3 systemic systemic JJ cord-015021-pol2qm74 6524 4 effects effect NNS cord-015021-pol2qm74 6524 5 of of IN cord-015021-pol2qm74 6524 6 mediators mediator NNS cord-015021-pol2qm74 6524 7 such such JJ cord-015021-pol2qm74 6524 8 as as IN cord-015021-pol2qm74 6524 9 TNF TNF NNP cord-015021-pol2qm74 6524 10 , , , cord-015021-pol2qm74 6524 11 PAF PAF NNP cord-015021-pol2qm74 6524 12 or or CC cord-015021-pol2qm74 6524 13 interleukines interleukine NNS cord-015021-pol2qm74 6524 14 , , , cord-015021-pol2qm74 6524 15 local local JJ cord-015021-pol2qm74 6524 16 actions action NNS cord-015021-pol2qm74 6524 17 on on IN cord-015021-pol2qm74 6524 18 hepatic hepatic JJ cord-015021-pol2qm74 6524 19 microvasculature microvasculature NN cord-015021-pol2qm74 6524 20 and and CC cord-015021-pol2qm74 6524 21 hepatic hepatic JJ cord-015021-pol2qm74 6524 22 inflammatory inflammatory JJ cord-015021-pol2qm74 6524 23 response response NN cord-015021-pol2qm74 6524 24 have have VBP cord-015021-pol2qm74 6524 25 to to TO cord-015021-pol2qm74 6524 26 be be VB cord-015021-pol2qm74 6524 27 considered consider VBN cord-015021-pol2qm74 6524 28 . . . cord-015021-pol2qm74 6525 1 Our -PRON- PRP$ cord-015021-pol2qm74 6525 2 aim aim NN cord-015021-pol2qm74 6525 3 was be VBD cord-015021-pol2qm74 6525 4 to to TO cord-015021-pol2qm74 6525 5 assess assess VB cord-015021-pol2qm74 6525 6 the the DT cord-015021-pol2qm74 6525 7 role role NN cord-015021-pol2qm74 6525 8 of of IN cord-015021-pol2qm74 6525 9 TNF TNF NNP cord-015021-pol2qm74 6525 10 and and CC cord-015021-pol2qm74 6525 11 PAF PAF NNP cord-015021-pol2qm74 6525 12 by by IN cord-015021-pol2qm74 6525 13 blocking block VBG cord-015021-pol2qm74 6525 14 their -PRON- PRP$ cord-015021-pol2qm74 6525 15 effects effect NNS cord-015021-pol2qm74 6525 16 using use VBG cord-015021-pol2qm74 6525 17 anti anti JJ cord-015021-pol2qm74 6525 18 - - JJ cord-015021-pol2qm74 6525 19 TNF tnf JJ cord-015021-pol2qm74 6525 20 monoclonal monoclonal JJ cord-015021-pol2qm74 6525 21 antibody antibody NN cord-015021-pol2qm74 6525 22 , , , cord-015021-pol2qm74 6525 23 pentoxifylline pentoxifylline NNP cord-015021-pol2qm74 6525 24 and and CC cord-015021-pol2qm74 6525 25 a a DT cord-015021-pol2qm74 6525 26 PAF PAF NNP cord-015021-pol2qm74 6525 27 antagonist antagonist NN cord-015021-pol2qm74 6525 28 . . . cord-015021-pol2qm74 6526 1 Methnds methnd NNS cord-015021-pol2qm74 6526 2 : : : cord-015021-pol2qm74 6527 1 In in IN cord-015021-pol2qm74 6527 2 anesthetized anesthetized JJ cord-015021-pol2qm74 6527 3 SPRD SPRD NNS cord-015021-pol2qm74 6527 4 - - HYPH cord-015021-pol2qm74 6527 5 rats rat NNS cord-015021-pol2qm74 6527 6 , , , cord-015021-pol2qm74 6527 7 hemorrhagic hemorrhagic JJ cord-015021-pol2qm74 6527 8 shock shock NN cord-015021-pol2qm74 6527 9 was be VBD cord-015021-pol2qm74 6527 10 induced induce VBN cord-015021-pol2qm74 6527 11 by by IN cord-015021-pol2qm74 6527 12 withdrawl withdrawl NN cord-015021-pol2qm74 6527 13 of of IN cord-015021-pol2qm74 6527 14 arterial arterial JJ cord-015021-pol2qm74 6527 15 blood blood NN cord-015021-pol2qm74 6527 16 within within IN cord-015021-pol2qm74 6527 17 5 5 CD cord-015021-pol2qm74 6527 18 rain rain NN cord-015021-pol2qm74 6527 19 and and CC cord-015021-pol2qm74 6527 20 shock shock NN cord-015021-pol2qm74 6527 21 state state NN cord-015021-pol2qm74 6527 22 was be VBD cord-015021-pol2qm74 6527 23 hold hold NN cord-015021-pol2qm74 6527 24 for for IN cord-015021-pol2qm74 6527 25 1 1 CD cord-015021-pol2qm74 6527 26 h h NN cord-015021-pol2qm74 6527 27 at at IN cord-015021-pol2qm74 6527 28 a a DT cord-015021-pol2qm74 6527 29 MAP MAP NNP cord-015021-pol2qm74 6527 30 of of IN cord-015021-pol2qm74 6527 31 40 40 CD cord-015021-pol2qm74 6527 32 mm mm NN cord-015021-pol2qm74 6527 33 Hg hg NN cord-015021-pol2qm74 6527 34 ( ( -LRB- cord-015021-pol2qm74 6527 35 cardiac cardiac JJ cord-015021-pol2qm74 6527 36 output output NN cord-015021-pol2qm74 6527 37 of of IN cord-015021-pol2qm74 6527 38 50 50 CD cord-015021-pol2qm74 6527 39 % % NN cord-015021-pol2qm74 6527 40 ) ) -RRB- cord-015021-pol2qm74 6527 41 . . . cord-015021-pol2qm74 6528 1 Following follow VBG cord-015021-pol2qm74 6528 2 adequate adequate JJ cord-015021-pol2qm74 6528 3 resuscitation resuscitation NN cord-015021-pol2qm74 6528 4 with with IN cord-015021-pol2qm74 6528 5 60 60 CD cord-015021-pol2qm74 6528 6 % % NN cord-015021-pol2qm74 6528 7 of of IN cord-015021-pol2qm74 6528 8 shed shed JJ cord-015021-pol2qm74 6528 9 blood blood NN cord-015021-pol2qm74 6528 10 and and CC cord-015021-pol2qm74 6528 11 twice twice RB cord-015021-pol2qm74 6528 12 of of IN cord-015021-pol2qm74 6528 13 this this DT cord-015021-pol2qm74 6528 14 volume volume NN cord-015021-pol2qm74 6528 15 as as IN cord-015021-pol2qm74 6528 16 Ringer Ringer NNP cord-015021-pol2qm74 6528 17 's 's POS cord-015021-pol2qm74 6528 18 solntion solntion NN cord-015021-pol2qm74 6528 19 , , , cord-015021-pol2qm74 6528 20 animals animal NNS cord-015021-pol2qm74 6528 21 recovered recover VBD cord-015021-pol2qm74 6528 22 to to IN cord-015021-pol2qm74 6528 23 MAP MAP NNP cord-015021-pol2qm74 6529 1 > > XX cord-015021-pol2qm74 6530 1 1130 1130 CD cord-015021-pol2qm74 6530 2 mm mm NNP cord-015021-pol2qm74 6530 3 Hg Hg NNP cord-015021-pol2qm74 6530 4 and and CC cord-015021-pol2qm74 6530 5 CO co NN cord-015021-pol2qm74 6530 6 > > XX cord-015021-pol2qm74 6530 7 120 120 CD cord-015021-pol2qm74 6530 8 % % NN cord-015021-pol2qm74 6530 9 . . . cord-015021-pol2qm74 6531 1 Hepatic hepatic JJ cord-015021-pol2qm74 6531 2 microcirculation microcirculation NN cord-015021-pol2qm74 6531 3 and and CC cord-015021-pol2qm74 6531 4 sinusoidal sinusoidal JJ cord-015021-pol2qm74 6531 5 leukocyte leukocyte NN cord-015021-pol2qm74 6531 6 - - HYPH cord-015021-pol2qm74 6531 7 endothelium endothelium NN cord-015021-pol2qm74 6531 8 interactions interaction NNS cord-015021-pol2qm74 6531 9 were be VBD cord-015021-pol2qm74 6531 10 examined examine VBN cord-015021-pol2qm74 6531 11 by by IN cord-015021-pol2qm74 6531 12 intravital intravital NNP cord-015021-pol2qm74 6531 13 epi epi NNP cord-015021-pol2qm74 6531 14 - - HYPH cord-015021-pol2qm74 6531 15 fluorescence fluorescence NN cord-015021-pol2qm74 6531 16 microscopy microscopy NNS cord-015021-pol2qm74 6531 17 at at IN cord-015021-pol2qm74 6531 18 1 1 CD cord-015021-pol2qm74 6531 19 , , , cord-015021-pol2qm74 6531 20 3 3 CD cord-015021-pol2qm74 6531 21 , , , cord-015021-pol2qm74 6531 22 or or CC cord-015021-pol2qm74 6531 23 5 5 CD cord-015021-pol2qm74 6531 24 hours hour NNS cord-015021-pol2qm74 6531 25 after after IN cord-015021-pol2qm74 6531 26 resuscitation resuscitation NN cord-015021-pol2qm74 6531 27 . . . cord-015021-pol2qm74 6532 1 In in IN cord-015021-pol2qm74 6532 2 a a DT cord-015021-pol2qm74 6532 3 blinded blinded JJ cord-015021-pol2qm74 6532 4 fashion fashion NN cord-015021-pol2qm74 6532 5 , , , cord-015021-pol2qm74 6532 6 a a DT cord-015021-pol2qm74 6532 7 rat rat NN cord-015021-pol2qm74 6532 8 - - HYPH cord-015021-pol2qm74 6532 9 specific specific JJ cord-015021-pol2qm74 6532 10 monoclonal monoclonal JJ cord-015021-pol2qm74 6532 11 anti anti JJ cord-015021-pol2qm74 6532 12 - - JJ cord-015021-pol2qm74 6532 13 TNF tnf JJ cord-015021-pol2qm74 6532 14 antibody antibody NN cord-015021-pol2qm74 6532 15 [ [ -LRB- cord-015021-pol2qm74 6532 16 2 2 CD cord-015021-pol2qm74 6532 17 mg mg NNP cord-015021-pol2qm74 6532 18 / / SYM cord-015021-pol2qm74 6532 19 kg kg NNP cord-015021-pol2qm74 6532 20 , , , cord-015021-pol2qm74 6532 21 Celltech Celltech NNP cord-015021-pol2qm74 6532 22 , , , cord-015021-pol2qm74 6532 23 UK UK NNP cord-015021-pol2qm74 6532 24 ) ) -RRB- cord-015021-pol2qm74 6532 25 , , , cord-015021-pol2qm74 6532 26 pentoxffylline pentoxffylline NNP cord-015021-pol2qm74 6532 27 ( ( -LRB- cord-015021-pol2qm74 6532 28 PTX PTX NNP cord-015021-pol2qm74 6532 29 , , , cord-015021-pol2qm74 6532 30 50 50 CD cord-015021-pol2qm74 6532 31 mg mg NNP cord-015021-pol2qm74 6532 32 / / SYM cord-015021-pol2qm74 6532 33 kg kg NNS cord-015021-pol2qm74 6532 34 , , , cord-015021-pol2qm74 6532 35 Hoechst Hoechst NNP cord-015021-pol2qm74 6532 36 , , , cord-015021-pol2qm74 6532 37 D D NNP cord-015021-pol2qm74 6532 38 ) ) -RRB- cord-015021-pol2qm74 6532 39 , , , cord-015021-pol2qm74 6532 40 and and CC cord-015021-pol2qm74 6532 41 a a DT cord-015021-pol2qm74 6532 42 PAF PAF NNP cord-015021-pol2qm74 6532 43 antagonist antagonist NN cord-015021-pol2qm74 6532 44 ( ( -LRB- cord-015021-pol2qm74 6532 45 WEB web NN cord-015021-pol2qm74 6532 46 2086 2086 CD cord-015021-pol2qm74 6532 47 , , , cord-015021-pol2qm74 6532 48 Boehringer Boehringer NNP cord-015021-pol2qm74 6532 49 , , , cord-015021-pol2qm74 6532 50 Ingh Ingh NNP cord-015021-pol2qm74 6532 51 . . . cord-015021-pol2qm74 6532 52 , , , cord-015021-pol2qm74 6532 53 D D NNP cord-015021-pol2qm74 6532 54 ) ) -RRB- cord-015021-pol2qm74 6532 55 were be VBD cord-015021-pol2qm74 6532 56 given give VBN cord-015021-pol2qm74 6532 57 either either CC cord-015021-pol2qm74 6532 58 as as IN cord-015021-pol2qm74 6532 59 pretreatment pretreatment NN cord-015021-pol2qm74 6532 60 or or CC cord-015021-pol2qm74 6532 61 at at IN cord-015021-pol2qm74 6532 62 the the DT cord-015021-pol2qm74 6532 63 time time NN cord-015021-pol2qm74 6532 64 of of IN cord-015021-pol2qm74 6532 65 resuscitation resuscitation NN cord-015021-pol2qm74 6532 66 ( ( -LRB- cord-015021-pol2qm74 6532 67 n=6 n=6 JJ cord-015021-pol2qm74 6532 68 - - HYPH cord-015021-pol2qm74 6532 69 8 8 CD cord-015021-pol2qm74 6532 70 group group NN cord-015021-pol2qm74 6532 71 Bolla Bolla NNP cord-015021-pol2qm74 6532 72 . . . cord-015021-pol2qm74 6533 1 K K NNP cord-015021-pol2qm74 6533 2 * * NFP cord-015021-pol2qm74 6533 3 . . . cord-015021-pol2qm74 6533 4 , , , cord-015021-pol2qm74 6533 5 Duchateau Duchateau NNP cord-015021-pol2qm74 6533 6 , , , cord-015021-pol2qm74 6533 7 J. J. NNP cord-015021-pol2qm74 6533 8 , , , cord-015021-pol2qm74 6533 9 HajOs HajOs NNP cord-015021-pol2qm74 6533 10 , , , cord-015021-pol2qm74 6533 11 Gy Gy NNP cord-015021-pol2qm74 6533 12 . . NNP cord-015021-pol2qm74 6533 13 , , , cord-015021-pol2qm74 6533 14 Mbzes Mbzes NNP cord-015021-pol2qm74 6533 15 , , , cord-015021-pol2qm74 6533 16 T. T. NNP cord-015021-pol2qm74 6533 17 , , , cord-015021-pol2qm74 6533 18 Hern Hern NNP cord-015021-pol2qm74 6533 19 ~ ~ NNP cord-015021-pol2qm74 6533 20 di di NNP cord-015021-pol2qm74 6533 21 , , , cord-015021-pol2qm74 6533 22 F. F. NNP cord-015021-pol2qm74 6533 23 Prevention Prevention NNP cord-015021-pol2qm74 6533 24 of of IN cord-015021-pol2qm74 6533 25 temporary temporary JJ cord-015021-pol2qm74 6533 26 / / SYM cord-015021-pol2qm74 6533 27 secondary secondary JJ cord-015021-pol2qm74 6533 28 immune immune JJ cord-015021-pol2qm74 6533 29 deficiencies deficiency NNS cord-015021-pol2qm74 6533 30 or or CC cord-015021-pol2qm74 6533 31 reduction reduction NN cord-015021-pol2qm74 6533 32 of of IN cord-015021-pol2qm74 6533 33 their -PRON- PRP$ cord-015021-pol2qm74 6533 34 severity severity NN cord-015021-pol2qm74 6533 35 and/or and/or CC cord-015021-pol2qm74 6533 36 duration duration NN cord-015021-pol2qm74 6533 37 as as RB cord-015021-pol2qm74 6533 38 well well RB cord-015021-pol2qm74 6533 39 as as IN cord-015021-pol2qm74 6533 40 the the DT cord-015021-pol2qm74 6533 41 reduction reduction NN cord-015021-pol2qm74 6533 42 of of IN cord-015021-pol2qm74 6533 43 the the DT cord-015021-pol2qm74 6533 44 perifocal perifocal JJ cord-015021-pol2qm74 6533 45 inflammatory inflammatory JJ cord-015021-pol2qm74 6533 46 processes process NNS cord-015021-pol2qm74 6533 47 belong belong VBP cord-015021-pol2qm74 6533 48 to to IN cord-015021-pol2qm74 6533 49 the the DT cord-015021-pol2qm74 6533 50 rational rational JJ cord-015021-pol2qm74 6533 51 targets target NNS cord-015021-pol2qm74 6533 52 of of IN cord-015021-pol2qm74 6533 53 posttraumatic posttraumatic JJ cord-015021-pol2qm74 6533 54 / / SYM cord-015021-pol2qm74 6533 55 pedsurgical pedsurgical JJ cord-015021-pol2qm74 6533 56 medication medication NN cord-015021-pol2qm74 6533 57 . . . cord-015021-pol2qm74 6534 1 Such such PDT cord-015021-pol2qm74 6534 2 a a DT cord-015021-pol2qm74 6534 3 targeted target VBN cord-015021-pol2qm74 6534 4 medication medication NN cord-015021-pol2qm74 6534 5 can can MD cord-015021-pol2qm74 6534 6 result result VB cord-015021-pol2qm74 6534 7 in in IN cord-015021-pol2qm74 6534 8 less less RBR cord-015021-pol2qm74 6534 9 frequently frequently RB cord-015021-pol2qm74 6534 10 occurring occur VBG cord-015021-pol2qm74 6534 11 nosocomial nosocomial JJ cord-015021-pol2qm74 6534 12 infections infection NNS cord-015021-pol2qm74 6534 13 , , , cord-015021-pol2qm74 6534 14 and and CC cord-015021-pol2qm74 6534 15 in in IN cord-015021-pol2qm74 6534 16 reducing reduce VBG cord-015021-pol2qm74 6534 17 the the DT cord-015021-pol2qm74 6534 18 duration duration NN cord-015021-pol2qm74 6534 19 of of IN cord-015021-pol2qm74 6534 20 the the DT cord-015021-pol2qm74 6534 21 intensive intensive JJ cord-015021-pol2qm74 6534 22 care care NN cord-015021-pol2qm74 6534 23 and and CC cord-015021-pol2qm74 6534 24 convalescence convalescence NN cord-015021-pol2qm74 6534 25 period period NN cord-015021-pol2qm74 6534 26 . . . cord-015021-pol2qm74 6535 1 The the DT cord-015021-pol2qm74 6535 2 results result NNS cord-015021-pol2qm74 6535 3 of of IN cord-015021-pol2qm74 6535 4 in in FW cord-015021-pol2qm74 6535 5 vitro vitro FW cord-015021-pol2qm74 6535 6 studies study NNS cord-015021-pol2qm74 6535 7 performed perform VBN cord-015021-pol2qm74 6535 8 with with IN cord-015021-pol2qm74 6535 9 the the DT cord-015021-pol2qm74 6535 10 amino amino NN cord-015021-pol2qm74 6535 11 acid acid NN cord-015021-pol2qm74 6535 12 sequence sequence NN cord-015021-pol2qm74 6535 13 32 32 CD cord-015021-pol2qm74 6535 14 - - SYM cord-015021-pol2qm74 6535 15 35 35 CD cord-015021-pol2qm74 6535 16 of of IN cord-015021-pol2qm74 6535 17 thymopoietin thymopoietin NNS cord-015021-pol2qm74 6535 18 , , , cord-015021-pol2qm74 6535 19 i.e. i.e. FW cord-015021-pol2qm74 6535 20 , , , cord-015021-pol2qm74 6535 21 with with IN cord-015021-pol2qm74 6535 22 thymocartin thymocartin NNS cord-015021-pol2qm74 6535 23 in in IN cord-015021-pol2qm74 6535 24 whole whole JJ cord-015021-pol2qm74 6535 25 blood blood NN cord-015021-pol2qm74 6535 26 and and CC cord-015021-pol2qm74 6535 27 peripheral peripheral JJ cord-015021-pol2qm74 6535 28 mono mono JJ cord-015021-pol2qm74 6535 29 - - HYPH cord-015021-pol2qm74 6535 30 nuclear nuclear JJ cord-015021-pol2qm74 6535 31 celI(PBNC celi(pbnc CD cord-015021-pol2qm74 6535 32 ) ) -RRB- cord-015021-pol2qm74 6536 1 cultures culture NNS cord-015021-pol2qm74 6536 2 clearly clearly RB cord-015021-pol2qm74 6536 3 show show VBP cord-015021-pol2qm74 6536 4 some some DT cord-015021-pol2qm74 6536 5 characteristic characteristic JJ cord-015021-pol2qm74 6536 6 effects effect NNS cord-015021-pol2qm74 6536 7 of of IN cord-015021-pol2qm74 6536 8 this this DT cord-015021-pol2qm74 6536 9 immunomodulator immunomodulator NN cord-015021-pol2qm74 6536 10 . . . cord-015021-pol2qm74 6537 1 Preincubation preincubation NN cord-015021-pol2qm74 6537 2 with with IN cord-015021-pol2qm74 6537 3 the the DT cord-015021-pol2qm74 6537 4 tetrapeptide tetrapeptide NN cord-015021-pol2qm74 6537 5 significantly significantly RB cord-015021-pol2qm74 6537 6 ( ( -LRB- cord-015021-pol2qm74 6537 7 p p NN cord-015021-pol2qm74 6537 8 < < XX cord-015021-pol2qm74 6537 9 O.Ol O.Ol NNP cord-015021-pol2qm74 6537 10 ) ) -RRB- cord-015021-pol2qm74 6537 11 and and CC cord-015021-pol2qm74 6537 12 concentration concentration NN cord-015021-pol2qm74 6537 13 - - HYPH cord-015021-pol2qm74 6537 14 dependent dependent JJ cord-015021-pol2qm74 6537 15 reduced reduce VBD cord-015021-pol2qm74 6537 16 the the DT cord-015021-pol2qm74 6537 17 endotoxin(LPS)-induced endotoxin(LPS)-induced NNP cord-015021-pol2qm74 6537 18 TNFalfa TNFalfa NNP cord-015021-pol2qm74 6537 19 production production NN cord-015021-pol2qm74 6537 20 from from IN cord-015021-pol2qm74 6537 21 95,7 95,7 CD cord-015021-pol2qm74 6537 22 to to IN cord-015021-pol2qm74 6537 23 about about IN cord-015021-pol2qm74 6537 24 20 20 CD cord-015021-pol2qm74 6537 25 pglml pglml NNS cord-015021-pol2qm74 6537 26 , , , cord-015021-pol2qm74 6537 27 but but CC cord-015021-pol2qm74 6537 28 did do VBD cord-015021-pol2qm74 6537 29 not not RB cord-015021-pol2qm74 6537 30 abolish abolish VB cord-015021-pol2qm74 6537 31 it -PRON- PRP cord-015021-pol2qm74 6537 32 . . . cord-015021-pol2qm74 6538 1 The the DT cord-015021-pol2qm74 6538 2 inhibition inhibition NN cord-015021-pol2qm74 6538 3 of of IN cord-015021-pol2qm74 6538 4 the the DT cord-015021-pol2qm74 6538 5 LPS(0.1 LPS(0.1 NNP cord-015021-pol2qm74 6538 6 ug ug NNP cord-015021-pol2qm74 6538 7 / / SYM cord-015021-pol2qm74 6538 8 ml)-induced ml)-induced NNP cord-015021-pol2qm74 6538 9 TNF TNF NNP cord-015021-pol2qm74 6538 10 production production NN cord-015021-pol2qm74 6538 11 occured occur VBD cord-015021-pol2qm74 6538 12 already already RB cord-015021-pol2qm74 6538 13 in in IN cord-015021-pol2qm74 6538 14 presence presence NN cord-015021-pol2qm74 6538 15 of of IN cord-015021-pol2qm74 6538 16 0,1 0,1 CD cord-015021-pol2qm74 6538 17 pg pg NNP cord-015021-pol2qm74 6538 18 peptide peptide NNP cord-015021-pol2qm74 6538 19 / / SYM cord-015021-pol2qm74 6538 20 ml ml NN cord-015021-pol2qm74 6538 21 and and CC cord-015021-pol2qm74 6538 22 peaked peak VBD cord-015021-pol2qm74 6538 23 at at IN cord-015021-pol2qm74 6538 24 the the DT cord-015021-pol2qm74 6538 25 concentration concentration NN cord-015021-pol2qm74 6538 26 of of IN cord-015021-pol2qm74 6538 27 0,01 0,01 NN cord-015021-pol2qm74 6538 28 ng ng NNP cord-015021-pol2qm74 6538 29 / / SYM cord-015021-pol2qm74 6538 30 ml ml NN cord-015021-pol2qm74 6538 31 . . . cord-015021-pol2qm74 6539 1 Higher high JJR cord-015021-pol2qm74 6539 2 concentrations concentration NNS cord-015021-pol2qm74 6539 3 did do VBD cord-015021-pol2qm74 6539 4 not not RB cord-015021-pol2qm74 6539 5 increase increase VB cord-015021-pol2qm74 6539 6 this this DT cord-015021-pol2qm74 6539 7 effect effect NN cord-015021-pol2qm74 6539 8 . . . cord-015021-pol2qm74 6540 1 In in IN cord-015021-pol2qm74 6540 2 contrast contrast NN cord-015021-pol2qm74 6540 3 to to IN cord-015021-pol2qm74 6540 4 the the DT cord-015021-pol2qm74 6540 5 other other JJ cord-015021-pol2qm74 6540 6 two two CD cord-015021-pol2qm74 6540 7 small small JJ cord-015021-pol2qm74 6540 8 thymic thymic JJ cord-015021-pol2qm74 6540 9 peptides peptide NNS cord-015021-pol2qm74 6540 10 ( ( -LRB- cord-015021-pol2qm74 6540 11 TP-3 TP-3 NNP cord-015021-pol2qm74 6540 12 and and CC cord-015021-pol2qm74 6540 13 TP-5 TP-5 NNP cord-015021-pol2qm74 6540 14 ) ) -RRB- cord-015021-pol2qm74 6540 15 , , , cord-015021-pol2qm74 6540 16 thymocartin thymocartin NNP cord-015021-pol2qm74 6540 17 did do VBD cord-015021-pol2qm74 6540 18 not not RB cord-015021-pol2qm74 6540 19 enhanced enhance VBN cord-015021-pol2qm74 6540 20 the the DT cord-015021-pol2qm74 6540 21 PWM PWM NNP cord-015021-pol2qm74 6540 22 - - HYPH cord-015021-pol2qm74 6540 23 induced induce VBN cord-015021-pol2qm74 6540 24 PGE PGE NNP cord-015021-pol2qm74 6540 25 2 2 CD cord-015021-pol2qm74 6540 26 production production NN cord-015021-pol2qm74 6540 27 in in IN cord-015021-pol2qm74 6540 28 PBMC PBMC NNP cord-015021-pol2qm74 6540 29 cultures culture NNS cord-015021-pol2qm74 6540 30 up up RP cord-015021-pol2qm74 6540 31 to to IN cord-015021-pol2qm74 6540 32 a a DT cord-015021-pol2qm74 6540 33 concentration concentration NN cord-015021-pol2qm74 6540 34 of of IN cord-015021-pol2qm74 6540 35 1 1 CD cord-015021-pol2qm74 6540 36 ng ng NN cord-015021-pol2qm74 6540 37 / / SYM cord-015021-pol2qm74 6540 38 ml ml NN cord-015021-pol2qm74 6540 39 , , , cord-015021-pol2qm74 6540 40 inclusive inclusive JJ cord-015021-pol2qm74 6540 41 . . . cord-015021-pol2qm74 6541 1 The the DT cord-015021-pol2qm74 6541 2 selection selection NN cord-015021-pol2qm74 6541 3 of of IN cord-015021-pol2qm74 6541 4 thymocartin thymocartin NNP cord-015021-pol2qm74 6541 5 ( ( -LRB- cord-015021-pol2qm74 6541 6 TP-4 TP-4 NNP cord-015021-pol2qm74 6541 7 ) ) -RRB- cord-015021-pol2qm74 6541 8 for for IN cord-015021-pol2qm74 6541 9 perisurgical perisurgical JJ cord-015021-pol2qm74 6541 10 medication medication NN cord-015021-pol2qm74 6541 11 and/or and/or CC cord-015021-pol2qm74 6541 12 for for IN cord-015021-pol2qm74 6541 13 treatment treatment NN cord-015021-pol2qm74 6541 14 of of IN cord-015021-pol2qm74 6541 15 trauma trauma NN cord-015021-pol2qm74 6541 16 - - HYPH cord-015021-pol2qm74 6541 17 induced induce VBN cord-015021-pol2qm74 6541 18 temporary temporary JJ cord-015021-pol2qm74 6541 19 immune immune JJ cord-015021-pol2qm74 6541 20 depression depression NN cord-015021-pol2qm74 6541 21 has have VBZ cord-015021-pol2qm74 6541 22 been be VBN cord-015021-pol2qm74 6541 23 strongly strongly RB cord-015021-pol2qm74 6541 24 supported support VBN cord-015021-pol2qm74 6541 25 also also RB cord-015021-pol2qm74 6541 26 by by IN cord-015021-pol2qm74 6541 27 targeted target VBN cord-015021-pol2qm74 6541 28 animal animal NN cord-015021-pol2qm74 6541 29 experiments experiment NNS cord-015021-pol2qm74 6541 30 . . . cord-015021-pol2qm74 6542 1 Thus thus RB cord-015021-pol2qm74 6542 2 , , , cord-015021-pol2qm74 6542 3 mortality mortality NN cord-015021-pol2qm74 6542 4 of of IN cord-015021-pol2qm74 6542 5 about about RB cord-015021-pol2qm74 6542 6 90 90 CD cord-015021-pol2qm74 6542 7 % % NN cord-015021-pol2qm74 6542 8 registered register VBN cord-015021-pol2qm74 6542 9 in in IN cord-015021-pol2qm74 6542 10 mice mouse NNS cord-015021-pol2qm74 6542 11 infected infect VBN cord-015021-pol2qm74 6542 12 with with IN cord-015021-pol2qm74 6542 13 Pseudomonas Pseudomonas NNP cord-015021-pol2qm74 6542 14 aeruginosa aeruginosa NN cord-015021-pol2qm74 6542 15 after after IN cord-015021-pol2qm74 6542 16 bum bum NN cord-015021-pol2qm74 6542 17 injury injury NN cord-015021-pol2qm74 6542 18 could could MD cord-015021-pol2qm74 6542 19 be be VB cord-015021-pol2qm74 6542 20 reduced reduce VBN cord-015021-pol2qm74 6542 21 with with IN cord-015021-pol2qm74 6542 22 the the DT cord-015021-pol2qm74 6542 23 tetrapeptide tetrapeptide NN cord-015021-pol2qm74 6542 24 treatment treatment NN cord-015021-pol2qm74 6542 25 to to IN cord-015021-pol2qm74 6542 26 a a DT cord-015021-pol2qm74 6542 27 level level NN cord-015021-pol2qm74 6542 28 which which WDT cord-015021-pol2qm74 6542 29 did do VBD cord-015021-pol2qm74 6542 30 not not RB cord-015021-pol2qm74 6542 31 differ differ VB cord-015021-pol2qm74 6542 32 significantly significantly RB cord-015021-pol2qm74 6542 33 from from IN cord-015021-pol2qm74 6542 34 that that DT cord-015021-pol2qm74 6542 35 of of IN cord-015021-pol2qm74 6542 36 the the DT cord-015021-pol2qm74 6542 37 infected infect VBN cord-015021-pol2qm74 6542 38 non non JJ cord-015021-pol2qm74 6542 39 - - JJ cord-015021-pol2qm74 6542 40 burned burn VBN cord-015021-pol2qm74 6542 41 controls control NNS cord-015021-pol2qm74 6542 42 . . . cord-015021-pol2qm74 6543 1 Moreover moreover RB cord-015021-pol2qm74 6543 2 , , , cord-015021-pol2qm74 6543 3 observations observation NNS cord-015021-pol2qm74 6543 4 gathered gather VBD cord-015021-pol2qm74 6543 5 first first RB cord-015021-pol2qm74 6543 6 of of IN cord-015021-pol2qm74 6543 7 all all DT cord-015021-pol2qm74 6543 8 with with IN cord-015021-pol2qm74 6543 9 the the DT cord-015021-pol2qm74 6543 10 inflammatory inflammatory JJ cord-015021-pol2qm74 6543 11 model model NN cord-015021-pol2qm74 6543 12 of of IN cord-015021-pol2qm74 6543 13 air air NN cord-015021-pol2qm74 6543 14 poach poach NNP cord-015021-pol2qm74 6543 15 / / SYM cord-015021-pol2qm74 6543 16 croton croton NNP cord-015021-pol2qm74 6543 17 oil oil NN cord-015021-pol2qm74 6543 18 grenuloma grenuloma NN cord-015021-pol2qm74 6543 19 ( ( -LRB- cord-015021-pol2qm74 6543 20 SELYE SELYE NNP cord-015021-pol2qm74 6543 21 ) ) -RRB- cord-015021-pol2qm74 6543 22 clearly clearly RB cord-015021-pol2qm74 6543 23 showed show VBD cord-015021-pol2qm74 6543 24 , , , cord-015021-pol2qm74 6543 25 that that IN cord-015021-pol2qm74 6543 26 a a DT cord-015021-pol2qm74 6543 27 very very RB cord-015021-pol2qm74 6543 28 definite definite JJ cord-015021-pol2qm74 6543 29 , , , cord-015021-pol2qm74 6543 30 antiexudative antiexudative JJ cord-015021-pol2qm74 6543 31 effect effect NN cord-015021-pol2qm74 6543 32 can can MD cord-015021-pol2qm74 6543 33 be be VB cord-015021-pol2qm74 6543 34 achieved achieve VBN cord-015021-pol2qm74 6543 35 with with IN cord-015021-pol2qm74 6543 36 this this DT cord-015021-pol2qm74 6543 37 thymic thymic JJ cord-015021-pol2qm74 6543 38 peptide peptide NN cord-015021-pol2qm74 6543 39 . . . cord-015021-pol2qm74 6544 1 As as IN cord-015021-pol2qm74 6544 2 to to IN cord-015021-pol2qm74 6544 3 this this DT cord-015021-pol2qm74 6544 4 effect effect NN cord-015021-pol2qm74 6544 5 , , , cord-015021-pol2qm74 6544 6 thymocartin thymocartin NNP cord-015021-pol2qm74 6544 7 has have VBZ cord-015021-pol2qm74 6544 8 been be VBN cord-015021-pol2qm74 6544 9 confirmed confirm VBN cord-015021-pol2qm74 6544 10 , , , cord-015021-pol2qm74 6544 11 e.g. e.g. RB cord-015021-pol2qm74 6544 12 , , , cord-015021-pol2qm74 6544 13 to to TO cord-015021-pol2qm74 6544 14 be be VB cord-015021-pol2qm74 6544 15 equipotent equipotent JJ cord-015021-pol2qm74 6544 16 with with IN cord-015021-pol2qm74 6544 17 locally locally RB cord-015021-pol2qm74 6544 18 administered administer VBN cord-015021-pol2qm74 6544 19 fluocinolone fluocinolone NN cord-015021-pol2qm74 6544 20 acetonide acetonide NN cord-015021-pol2qm74 6544 21 and/or and/or CC cord-015021-pol2qm74 6545 1 s.c s.c NNP cord-015021-pol2qm74 6545 2 . . NNP cord-015021-pol2qm74 6545 3 injected inject VBD cord-015021-pol2qm74 6545 4 prednisolone prednisolone NN cord-015021-pol2qm74 6545 5 . . . cord-015021-pol2qm74 6546 1 The the DT cord-015021-pol2qm74 6546 2 interim interim JJ cord-015021-pol2qm74 6546 3 results result NNS cord-015021-pol2qm74 6546 4 of of IN cord-015021-pol2qm74 6546 5 two two CD cord-015021-pol2qm74 6546 6 explorative explorative JJ cord-015021-pol2qm74 6546 7 double double JJ cord-015021-pol2qm74 6546 8 - - HYPH cord-015021-pol2qm74 6546 9 blind blind JJ cord-015021-pol2qm74 6546 10 clinical clinical JJ cord-015021-pol2qm74 6546 11 studies study NNS cord-015021-pol2qm74 6546 12 ( ( -LRB- cord-015021-pol2qm74 6546 13 involving involve VBG cord-015021-pol2qm74 6546 14 more more JJR cord-015021-pol2qm74 6546 15 than than IN cord-015021-pol2qm74 6546 16 260 260 CD cord-015021-pol2qm74 6546 17 patients patient NNS cord-015021-pol2qm74 6546 18 after after IN cord-015021-pol2qm74 6546 19 polytrauma polytrauma NN cord-015021-pol2qm74 6546 20 and and CC cord-015021-pol2qm74 6546 21 hip hip NN cord-015021-pol2qm74 6546 22 - - HYPH cord-015021-pol2qm74 6546 23 fracture fracture NN cord-015021-pol2qm74 6546 24 untill untill NN cord-015021-pol2qm74 6546 25 now now RB cord-015021-pol2qm74 6546 26 , , , cord-015021-pol2qm74 6546 27 respectively respectively RB cord-015021-pol2qm74 6546 28 ) ) -RRB- cord-015021-pol2qm74 6546 29 correspond correspond VBP cord-015021-pol2qm74 6546 30 to to IN cord-015021-pol2qm74 6546 31 the the DT cord-015021-pol2qm74 6546 32 expectations expectation NNS cord-015021-pol2qm74 6546 33 . . . cord-015021-pol2qm74 6547 1 The the DT cord-015021-pol2qm74 6547 2 treatment treatment NN cord-015021-pol2qm74 6547 3 significantly significantly RB cord-015021-pol2qm74 6547 4 reduced reduce VBD cord-015021-pol2qm74 6547 5 the the DT cord-015021-pol2qm74 6547 6 occurence occurence NN cord-015021-pol2qm74 6547 7 of of IN cord-015021-pol2qm74 6547 8 nosocomial nosocomial JJ cord-015021-pol2qm74 6547 9 infections infection NNS cord-015021-pol2qm74 6547 10 , , , cord-015021-pol2qm74 6547 11 the the DT cord-015021-pol2qm74 6547 12 days day NNS cord-015021-pol2qm74 6547 13 spend spend VBP cord-015021-pol2qm74 6547 14 in in IN cord-015021-pol2qm74 6547 15 intensive intensive JJ cord-015021-pol2qm74 6547 16 care care NN cord-015021-pol2qm74 6547 17 and and CC cord-015021-pol2qm74 6547 18 on on IN cord-015021-pol2qm74 6547 19 antibiotics antibiotic NNS cord-015021-pol2qm74 6547 20 as as RB cord-015021-pol2qm74 6547 21 well well RB cord-015021-pol2qm74 6547 22 as as IN cord-015021-pol2qm74 6547 23 it -PRON- PRP cord-015021-pol2qm74 6547 24 shortened shorten VBD cord-015021-pol2qm74 6547 25 the the DT cord-015021-pol2qm74 6547 26 bed bed NN cord-015021-pol2qm74 6547 27 - - HYPH cord-015021-pol2qm74 6547 28 out out RP cord-015021-pol2qm74 6547 29 time time NN cord-015021-pol2qm74 6547 30 and and CC cord-015021-pol2qm74 6547 31 reduced reduce VBD cord-015021-pol2qm74 6547 32 the the DT cord-015021-pol2qm74 6547 33 additional additional JJ cord-015021-pol2qm74 6547 34 medication medication NN cord-015021-pol2qm74 6547 35 . . . cord-015021-pol2qm74 6548 1 Objective objective NN cord-015021-pol2qm74 6548 2 of of IN cord-015021-pol2qm74 6548 3 this this DT cord-015021-pol2qm74 6548 4 prospective prospective JJ cord-015021-pol2qm74 6548 5 randomized randomized JJ cord-015021-pol2qm74 6548 6 study study NN cord-015021-pol2qm74 6548 7 was be VBD cord-015021-pol2qm74 6548 8 to to TO cord-015021-pol2qm74 6548 9 further further RB cord-015021-pol2qm74 6548 10 delineate delineate VB cord-015021-pol2qm74 6548 11 the the DT cord-015021-pol2qm74 6548 12 mechanisms mechanism NNS cord-015021-pol2qm74 6548 13 leading lead VBG cord-015021-pol2qm74 6548 14 to to IN cord-015021-pol2qm74 6548 15 these these DT cord-015021-pol2qm74 6548 16 alterations alteration NNS cord-015021-pol2qm74 6548 17 and and CC cord-015021-pol2qm74 6548 18 to to TO cord-015021-pol2qm74 6548 19 investigate investigate VB cord-015021-pol2qm74 6548 20 the the DT cord-015021-pol2qm74 6548 21 effects effect NNS cord-015021-pol2qm74 6548 22 of of IN cord-015021-pol2qm74 6548 23 immunomodulatory immunomodulatory JJ cord-015021-pol2qm74 6548 24 intervention intervention NN cord-015021-pol2qm74 6548 25 . . . cord-015021-pol2qm74 6549 1 Patients patient NNS cord-015021-pol2qm74 6549 2 and and CC cord-015021-pol2qm74 6549 3 Methods method NNS cord-015021-pol2qm74 6549 4 : : : cord-015021-pol2qm74 6549 5 20 20 CD cord-015021-pol2qm74 6549 6 patients patient NNS cord-015021-pol2qm74 6549 7 ( ( -LRB- cord-015021-pol2qm74 6549 8 pts pts NNP cord-015021-pol2qm74 6549 9 ) ) -RRB- cord-015021-pol2qm74 6549 10 formed form VBN cord-015021-pol2qm74 6550 1 control control NNP cord-015021-pol2qm74 6550 2 group group NNP cord-015021-pol2qm74 6550 3 A. A. NNP cord-015021-pol2qm74 6550 4 20 20 CD cord-015021-pol2qm74 6550 5 group group NN cord-015021-pol2qm74 6550 6 B b NN cord-015021-pol2qm74 6550 7 pts pts NNP cord-015021-pol2qm74 6550 8 received receive VBD cord-015021-pol2qm74 6550 9 3x50 3x50 CD cord-015021-pol2qm74 6550 10 mg mg NNP cord-015021-pol2qm74 6550 11 Indomethacin Indomethacin NNP cord-015021-pol2qm74 6550 12 ( ( -LRB- cord-015021-pol2qm74 6550 13 Indo Indo NNP cord-015021-pol2qm74 6550 14 ) ) -RRB- cord-015021-pol2qm74 6550 15 from from IN cord-015021-pol2qm74 6550 16 the the DT cord-015021-pol2qm74 6550 17 first first JJ cord-015021-pol2qm74 6550 18 ( ( -LRB- cord-015021-pol2qm74 6550 19 dl dl NNP cord-015021-pol2qm74 6550 20 ) ) -RRB- cord-015021-pol2qm74 6550 21 to to IN cord-015021-pol2qm74 6550 22 the the DT cord-015021-pol2qm74 6550 23 fourth fourth JJ cord-015021-pol2qm74 6550 24 postoperative postoperative JJ cord-015021-pol2qm74 6550 25 day day NN cord-015021-pol2qm74 6550 26 ( ( -LRB- cord-015021-pol2qm74 6550 27 d5 d5 NNP cord-015021-pol2qm74 6550 28 ) ) -RRB- cord-015021-pol2qm74 6550 29 intravenously intravenously RB cord-015021-pol2qm74 6550 30 to to TO cord-015021-pol2qm74 6550 31 block block VB cord-015021-pol2qm74 6550 32 prostaglandin prostaglandin NN cord-015021-pol2qm74 6550 33 E2induced e2induced CD cord-015021-pol2qm74 6550 34 suppression suppression NN cord-015021-pol2qm74 6550 35 of of IN cord-015021-pol2qm74 6550 36 CMI CMI NNP cord-015021-pol2qm74 6550 37 response response NN cord-015021-pol2qm74 6550 38 as as RB cord-015021-pol2qm74 6550 39 well well RB cord-015021-pol2qm74 6550 40 as as IN cord-015021-pol2qm74 6551 1 50 50 CD cord-015021-pol2qm74 6551 2 mg mg NNP cord-015021-pol2qm74 6551 3 Thymopentin Thymopentin NNP cord-015021-pol2qm74 6551 4 ( ( -LRB- cord-015021-pol2qm74 6551 5 TP-5 TP-5 NNP cord-015021-pol2qm74 6551 6 ) ) -RRB- cord-015021-pol2qm74 6551 7 subcutaneously subcutaneously RB cord-015021-pol2qm74 6551 8 preop preop NNP cord-015021-pol2qm74 6551 9 . . NNP cord-015021-pol2qm74 6551 10 , , , cord-015021-pol2qm74 6551 11 on on IN cord-015021-pol2qm74 6551 12 d2 d2 NN cord-015021-pol2qm74 6551 13 and and CC cord-015021-pol2qm74 6551 14 d4 d4 NN cord-015021-pol2qm74 6551 15 to to TO cord-015021-pol2qm74 6551 16 augment augment VB cord-015021-pol2qm74 6551 17 CMI CMI NNP cord-015021-pol2qm74 6551 18 reactivity reactivity NN cord-015021-pol2qm74 6551 19 . . . cord-015021-pol2qm74 6552 1 In in IN cord-015021-pol2qm74 6552 2 vitro vitro FW cord-015021-pol2qm74 6552 3 investigations investigation NNS cord-015021-pol2qm74 6552 4 preoperatively preoperatively RB cord-015021-pol2qm74 6552 5 , , , cord-015021-pol2qm74 6552 6 on on IN cord-015021-pol2qm74 6552 7 dl dl NNP cord-015021-pol2qm74 6552 8 and and CC cord-015021-pol2qm74 6552 9 d7 d7 NNP cord-015021-pol2qm74 6552 10 included include VBD cord-015021-pol2qm74 6552 11 measurements measurement NNS cord-015021-pol2qm74 6552 12 of of IN cord-015021-pol2qm74 6552 13 the the DT cord-015021-pol2qm74 6552 14 percentage percentage NN cord-015021-pol2qm74 6552 15 of of IN cord-015021-pol2qm74 6552 16 CD4 CD4 NNP cord-015021-pol2qm74 6552 17 + + CC cord-015021-pol2qm74 6552 18 T t NN cord-015021-pol2qm74 6552 19 - - HYPH cord-015021-pol2qm74 6552 20 helper helper NN cord-015021-pol2qm74 6552 21 ( ( -LRB- cord-015021-pol2qm74 6552 22 TH TH NNP cord-015021-pol2qm74 6552 23 ) ) -RRB- cord-015021-pol2qm74 6552 24 cells cell NNS cord-015021-pol2qm74 6552 25 , , , cord-015021-pol2qm74 6552 26 pbytohemagglutinin pbytohemagglutinin JJ cord-015021-pol2qm74 6552 27 ( ( -LRB- cord-015021-pol2qm74 6552 28 PHA)induced pha)induce VBN cord-015021-pol2qm74 6552 29 synthesis synthesis NN cord-015021-pol2qm74 6552 30 of of IN cord-015021-pol2qm74 6552 31 interleukin interleukin NN cord-015021-pol2qm74 6552 32 ( ( -LRB- cord-015021-pol2qm74 6552 33 IL)-2 il)-2 RB cord-015021-pol2qm74 6552 34 as as IN cord-015021-pol2qm74 6552 35 one one CD cord-015021-pol2qm74 6552 36 cytokine cytokine NN cord-015021-pol2qm74 6552 37 primarily primarily RB cord-015021-pol2qm74 6552 38 produced produce VBN cord-015021-pol2qm74 6552 39 by by IN cord-015021-pol2qm74 6552 40 THl THl NNS cord-015021-pol2qm74 6552 41 - - HYPH cord-015021-pol2qm74 6552 42 cells cell NNS cord-015021-pol2qm74 6552 43 , , , cord-015021-pol2qm74 6552 44 and and CC cord-015021-pol2qm74 6552 45 PHA PHA NNP cord-015021-pol2qm74 6552 46 - - HYPH cord-015021-pol2qm74 6552 47 induced induce VBN cord-015021-pol2qm74 6552 48 synthesis synthesis NN cord-015021-pol2qm74 6552 49 of of IN cord-015021-pol2qm74 6552 50 IL-6 IL-6 NNP cord-015021-pol2qm74 6552 51 as as IN cord-015021-pol2qm74 6552 52 one one CD cord-015021-pol2qm74 6552 53 cytokine cytokine NN cord-015021-pol2qm74 6552 54 primarily primarily RB cord-015021-pol2qm74 6552 55 produced produce VBN cord-015021-pol2qm74 6552 56 by by IN cord-015021-pol2qm74 6552 57 TH2-cells th2-cell NNS cord-015021-pol2qm74 6552 58 . . . cord-015021-pol2qm74 6553 1 Delayed delay VBN cord-015021-pol2qm74 6553 2 type type NN cord-015021-pol2qm74 6553 3 hypersensitivity hypersensitivity NN cord-015021-pol2qm74 6553 4 ( ( -LRB- cord-015021-pol2qm74 6553 5 DTH DTH NNP cord-015021-pol2qm74 6553 6 ) ) -RRB- cord-015021-pol2qm74 6553 7 skin skin NN cord-015021-pol2qm74 6553 8 response response NN cord-015021-pol2qm74 6553 9 to to IN cord-015021-pol2qm74 6553 10 an an DT cord-015021-pol2qm74 6553 11 antigen antigen NN cord-015021-pol2qm74 6553 12 skin skin NN cord-015021-pol2qm74 6553 13 test test NN cord-015021-pol2qm74 6553 14 battery battery NN cord-015021-pol2qm74 6553 15 and and CC cord-015021-pol2qm74 6553 16 specific specific JJ cord-015021-pol2qm74 6553 17 antibody antibody NN cord-015021-pol2qm74 6553 18 ( ( -LRB- cord-015021-pol2qm74 6553 19 AB ab NN cord-015021-pol2qm74 6553 20 ) ) -RRB- cord-015021-pol2qm74 6553 21 production production NN cord-015021-pol2qm74 6553 22 following follow VBG cord-015021-pol2qm74 6553 23 tetanus tetanus JJ cord-015021-pol2qm74 6553 24 vaccination vaccination NN cord-015021-pol2qm74 6553 25 preoperatively preoperatively NN cord-015021-pol2qm74 6553 26 and and CC cord-015021-pol2qm74 6553 27 on on IN cord-015021-pol2qm74 6553 28 d7 d7 NNP cord-015021-pol2qm74 6553 29 were be VBD cord-015021-pol2qm74 6553 30 used use VBN cord-015021-pol2qm74 6553 31 as as IN cord-015021-pol2qm74 6553 32 in in IN cord-015021-pol2qm74 6553 33 vivo vivo NN cord-015021-pol2qm74 6553 34 tests test NNS cord-015021-pol2qm74 6553 35 for for IN cord-015021-pol2qm74 6553 36 THl THl NNP cord-015021-pol2qm74 6553 37 - - : cord-015021-pol2qm74 6553 38 and and CC cord-015021-pol2qm74 6553 39 TH2-induced TH2-induced NNP cord-015021-pol2qm74 6553 40 immune immune JJ cord-015021-pol2qm74 6553 41 response response NN cord-015021-pol2qm74 6553 42 respectively respectively RB cord-015021-pol2qm74 6553 43 . . . cord-015021-pol2qm74 6554 1 Results result NNS cord-015021-pol2qm74 6554 2 : : : cord-015021-pol2qm74 6555 1 Postoperatively postoperatively RB cord-015021-pol2qm74 6555 2 , , , cord-015021-pol2qm74 6555 3 group group NN cord-015021-pol2qm74 6555 4 A a DT cord-015021-pol2qm74 6555 5 pts pts NN cord-015021-pol2qm74 6555 6 showed show VBD cord-015021-pol2qm74 6555 7 a a DT cord-015021-pol2qm74 6555 8 persistent persistent JJ cord-015021-pol2qm74 6555 9 significant significant JJ cord-015021-pol2qm74 6555 10 reduction reduction NN cord-015021-pol2qm74 6555 11 of of IN cord-015021-pol2qm74 6555 12 CD4 CD4 NNP cord-015021-pol2qm74 6555 13 + + CC cord-015021-pol2qm74 6555 14 TH TH NNP cord-015021-pol2qm74 6555 15 cells cell NNS cord-015021-pol2qm74 6555 16 , , , cord-015021-pol2qm74 6555 17 IL-2 IL-2 NNP cord-015021-pol2qm74 6555 18 / / SYM cord-015021-pol2qm74 6555 19 IL-6 IL-6 NNP cord-015021-pol2qm74 6555 20 ratio ratio NN cord-015021-pol2qm74 6555 21 , , , cord-015021-pol2qm74 6555 22 and and CC cord-015021-pol2qm74 6555 23 DTH DTH NNP cord-015021-pol2qm74 6555 24 skin skin NN cord-015021-pol2qm74 6555 25 response response NN cord-015021-pol2qm74 6555 26 as as IN cord-015021-pol2qm74 6555 27 compared compare VBN cord-015021-pol2qm74 6555 28 to to IN cord-015021-pol2qm74 6555 29 baseline baseline JJ cord-015021-pol2qm74 6555 30 values value NNS cord-015021-pol2qm74 6555 31 ( ( -LRB- cord-015021-pol2qm74 6555 32 BL BL NNP cord-015021-pol2qm74 6555 33 ) ) -RRB- cord-015021-pol2qm74 6555 34 , , , cord-015021-pol2qm74 6555 35 while while IN cord-015021-pol2qm74 6555 36 AB AB NNP cord-015021-pol2qm74 6555 37 production production NN cord-015021-pol2qm74 6555 38 increased increase VBD cord-015021-pol2qm74 6555 39 ( ( -LRB- cord-015021-pol2qm74 6555 40 p<0.05 p<0.05 CD cord-015021-pol2qm74 6555 41 vs vs IN cord-015021-pol2qm74 6555 42 . . . cord-015021-pol2qm74 6555 43 BL BL NNP cord-015021-pol2qm74 6555 44 ) ) -RRB- cord-015021-pol2qm74 6555 45 . . . cord-015021-pol2qm74 6556 1 In in IN cord-015021-pol2qm74 6556 2 group group NN cord-015021-pol2qm74 6556 3 B b NN cord-015021-pol2qm74 6556 4 pts pts NN cord-015021-pol2qm74 6556 5 no no DT cord-015021-pol2qm74 6556 6 change change NN cord-015021-pol2qm74 6556 7 in in IN cord-015021-pol2qm74 6556 8 CD4 CD4 NNP cord-015021-pol2qm74 6556 9 + + CC cord-015021-pol2qm74 6556 10 TH TH NNP cord-015021-pol2qm74 6556 11 cells cell NNS cord-015021-pol2qm74 6556 12 , , , cord-015021-pol2qm74 6557 1 IL-2 IL-2 NNP cord-015021-pol2qm74 6557 2 / / SYM cord-015021-pol2qm74 6557 3 IL-6 IL-6 NNP cord-015021-pol2qm74 6557 4 ratio ratio NN cord-015021-pol2qm74 6557 5 , , , cord-015021-pol2qm74 6557 6 or or CC cord-015021-pol2qm74 6557 7 DTH DTH NNP cord-015021-pol2qm74 6557 8 skin skin NN cord-015021-pol2qm74 6557 9 response response NN cord-015021-pol2qm74 6557 10 was be VBD cord-015021-pol2qm74 6557 11 observed observe VBN cord-015021-pol2qm74 6557 12 ( ( -LRB- cord-015021-pol2qm74 6557 13 p<0.05 p<0.05 JJ cord-015021-pol2qm74 6557 14 vs.group vs.group NNP cord-015021-pol2qm74 6557 15 A A NNP cord-015021-pol2qm74 6557 16 ) ) -RRB- cord-015021-pol2qm74 6557 17 , , , cord-015021-pol2qm74 6557 18 and and CC cord-015021-pol2qm74 6557 19 postoperative postoperative JJ cord-015021-pol2qm74 6557 20 AB ab NN cord-015021-pol2qm74 6557 21 production production NN cord-015021-pol2qm74 6557 22 increased increase VBD cord-015021-pol2qm74 6557 23 significantly significantly RB cord-015021-pol2qm74 6557 24 ( ( -LRB- cord-015021-pol2qm74 6557 25 n.s n.s NNP cord-015021-pol2qm74 6557 26 . . NNP cord-015021-pol2qm74 6557 27 vs. vs. CC cord-015021-pol2qm74 6557 28 group group NNP cord-015021-pol2qm74 6557 29 A A NNP cord-015021-pol2qm74 6557 30 ) ) -RRB- cord-015021-pol2qm74 6557 31 . . . cord-015021-pol2qm74 6558 1 Conclusions conclusion NNS cord-015021-pol2qm74 6558 2 : : : cord-015021-pol2qm74 6559 1 1.These 1.these CD cord-015021-pol2qm74 6559 2 results result NNS cord-015021-pol2qm74 6559 3 clearly clearly RB cord-015021-pol2qm74 6559 4 indicate indicate VBP cord-015021-pol2qm74 6559 5 a a DT cord-015021-pol2qm74 6559 6 significant significant JJ cord-015021-pol2qm74 6559 7 suppression suppression NN cord-015021-pol2qm74 6559 8 of of IN cord-015021-pol2qm74 6559 9 TH1 TH1 NNP cord-015021-pol2qm74 6559 10 induced induce VBN cord-015021-pol2qm74 6559 11 CMI CMI NNP cord-015021-pol2qm74 6559 12 response response NN cord-015021-pol2qm74 6559 13 , , , cord-015021-pol2qm74 6559 14 while while IN cord-015021-pol2qm74 6559 15 TH2 TH2 NNP cord-015021-pol2qm74 6559 16 induced induce VBD cord-015021-pol2qm74 6559 17 response response NN cord-015021-pol2qm74 6559 18 remains remain VBZ cord-015021-pol2qm74 6559 19 normal normal JJ cord-015021-pol2qm74 6559 20 following follow VBG cord-015021-pol2qm74 6559 21 OHS OHS NNP cord-015021-pol2qm74 6559 22 . . . cord-015021-pol2qm74 6560 1 2.These 2.these CD cord-015021-pol2qm74 6560 2 alterations alteration NNS cord-015021-pol2qm74 6560 3 may may MD cord-015021-pol2qm74 6560 4 gain gain VB cord-015021-pol2qm74 6560 5 clinical clinical JJ cord-015021-pol2qm74 6560 6 significance significance NN cord-015021-pol2qm74 6560 7 whenever whenever WRB cord-015021-pol2qm74 6560 8 a a DT cord-015021-pol2qm74 6560 9 postoperative postoperative JJ cord-015021-pol2qm74 6560 10 infection infection NN cord-015021-pol2qm74 6560 11 requires require VBZ cord-015021-pol2qm74 6560 12 a a DT cord-015021-pol2qm74 6560 13 TH1 TH1 NNP cord-015021-pol2qm74 6560 14 response response NN cord-015021-pol2qm74 6560 15 and and CC cord-015021-pol2qm74 6560 16 may may MD cord-015021-pol2qm74 6560 17 explain explain VB cord-015021-pol2qm74 6560 18 the the DT cord-015021-pol2qm74 6560 19 susceptibility susceptibility NN cord-015021-pol2qm74 6560 20 to to IN cord-015021-pol2qm74 6560 21 opportunistic opportunistic JJ cord-015021-pol2qm74 6560 22 microorganisms microorganism NNS cord-015021-pol2qm74 6560 23 observed observe VBN cord-015021-pol2qm74 6560 24 in in IN cord-015021-pol2qm74 6560 25 pts pts NN cord-015021-pol2qm74 6560 26 after after IN cord-015021-pol2qm74 6560 27 OHS OHS NNP cord-015021-pol2qm74 6560 28 . . . cord-015021-pol2qm74 6561 1 3 3 LS cord-015021-pol2qm74 6562 1 The the DT cord-015021-pol2qm74 6562 2 aim aim NN cord-015021-pol2qm74 6562 3 of of IN cord-015021-pol2qm74 6562 4 this this DT cord-015021-pol2qm74 6562 5 study study NN cord-015021-pol2qm74 6562 6 was be VBD cord-015021-pol2qm74 6562 7 to to TO cord-015021-pol2qm74 6562 8 find find VB cord-015021-pol2qm74 6562 9 out out RP cord-015021-pol2qm74 6562 10 whether whether IN cord-015021-pol2qm74 6562 11 the the DT cord-015021-pol2qm74 6562 12 establishment establishment NN cord-015021-pol2qm74 6562 13 of of IN cord-015021-pol2qm74 6562 14 administration administration NN cord-015021-pol2qm74 6562 15 of of IN cord-015021-pol2qm74 6562 16 Thymostimulin Thymostimulin NNP cord-015021-pol2qm74 6562 17 ( ( -LRB- cord-015021-pol2qm74 6562 18 TP tp NN cord-015021-pol2qm74 6562 19 - - HYPH cord-015021-pol2qm74 6562 20 I I NNP cord-015021-pol2qm74 6562 21 ) ) -RRB- cord-015021-pol2qm74 6562 22 in in IN cord-015021-pol2qm74 6562 23 jaundiced jaundiced JJ cord-015021-pol2qm74 6562 24 and and CC cord-015021-pol2qm74 6562 25 anergic anergic JJ cord-015021-pol2qm74 6562 26 rats rat NNS cord-015021-pol2qm74 6562 27 would would MD cord-015021-pol2qm74 6562 28 return return VB cord-015021-pol2qm74 6562 29 the the DT cord-015021-pol2qm74 6562 30 rats rat NNS cord-015021-pol2qm74 6562 31 to to IN cord-015021-pol2qm74 6562 32 the the DT cord-015021-pol2qm74 6562 33 state state NN cord-015021-pol2qm74 6562 34 of of IN cord-015021-pol2qm74 6562 35 immunocompetence immunocompetence NN cord-015021-pol2qm74 6562 36 . . . cord-015021-pol2qm74 6563 1 Material material NN cord-015021-pol2qm74 6563 2 and and CC cord-015021-pol2qm74 6563 3 Methods method NNS cord-015021-pol2qm74 6563 4 . . . cord-015021-pol2qm74 6564 1 Male male JJ cord-015021-pol2qm74 6564 2 Wistar Wistar NNP cord-015021-pol2qm74 6564 3 rats rat NNS cord-015021-pol2qm74 6564 4 weighing weigh VBG cord-015021-pol2qm74 6564 5 250 250 CD cord-015021-pol2qm74 6564 6 - - SYM cord-015021-pol2qm74 6564 7 300 300 CD cord-015021-pol2qm74 6564 8 g g NN cord-015021-pol2qm74 6564 9 were be VBD cord-015021-pol2qm74 6564 10 injected inject VBN cord-015021-pol2qm74 6564 11 with with IN cord-015021-pol2qm74 6564 12 haemocyanin haemocyanin NNP cord-015021-pol2qm74 6564 13 ( ( -LRB- cord-015021-pol2qm74 6564 14 KLH KLH NNP cord-015021-pol2qm74 6564 15 ) ) -RRB- cord-015021-pol2qm74 6564 16 . . . cord-015021-pol2qm74 6565 1 All all DT cord-015021-pol2qm74 6565 2 rats rat NNS cord-015021-pol2qm74 6565 3 with with IN cord-015021-pol2qm74 6565 4 a a DT cord-015021-pol2qm74 6565 5 positive positive JJ cord-015021-pol2qm74 6565 6 response response NN cord-015021-pol2qm74 6565 7 were be VBD cord-015021-pol2qm74 6565 8 included include VBN cord-015021-pol2qm74 6565 9 in in IN cord-015021-pol2qm74 6565 10 the the DT cord-015021-pol2qm74 6565 11 study study NN cord-015021-pol2qm74 6565 12 and and CC cord-015021-pol2qm74 6565 13 we -PRON- PRP cord-015021-pol2qm74 6565 14 evalu evalu VBP cord-015021-pol2qm74 6565 15 ated ate VBD cord-015021-pol2qm74 6565 16 the the DT cord-015021-pol2qm74 6565 17 T T NNP cord-015021-pol2qm74 6565 18 cell cell NN cord-015021-pol2qm74 6565 19 subpopulations subpopulation NNS cord-015021-pol2qm74 6565 20 and and CC cord-015021-pol2qm74 6565 21 IL-2 il-2 NN cord-015021-pol2qm74 6565 22 . . . cord-015021-pol2qm74 6566 1 They -PRON- PRP cord-015021-pol2qm74 6566 2 underwent undergo VBD cord-015021-pol2qm74 6566 3 laparotomy laparotomy NN cord-015021-pol2qm74 6566 4 and and CC cord-015021-pol2qm74 6566 5 the the DT cord-015021-pol2qm74 6566 6 common common JJ cord-015021-pol2qm74 6566 7 duct duct NN cord-015021-pol2qm74 6566 8 was be VBD cord-015021-pol2qm74 6566 9 ligated ligate VBN cord-015021-pol2qm74 6566 10 and and CC cord-015021-pol2qm74 6566 11 divided divide VBN cord-015021-pol2qm74 6566 12 . . . cord-015021-pol2qm74 6567 1 Those those DT cord-015021-pol2qm74 6567 2 rats rat NNS cord-015021-pol2qm74 6567 3 whic whic , cord-015021-pol2qm74 6567 4 become become VBP cord-015021-pol2qm74 6567 5 jaundiced jaundiced JJ cord-015021-pol2qm74 6567 6 and and CC cord-015021-pol2qm74 6567 7 anergic anergic JJ cord-015021-pol2qm74 6567 8 one one CD cord-015021-pol2qm74 6567 9 week week NN cord-015021-pol2qm74 6567 10 after after IN cord-015021-pol2qm74 6567 11 the the DT cord-015021-pol2qm74 6567 12 operation operation NN cord-015021-pol2qm74 6567 13 , , , cord-015021-pol2qm74 6567 14 were be VBD cord-015021-pol2qm74 6567 15 divided divide VBN cord-015021-pol2qm74 6567 16 in in IN cord-015021-pol2qm74 6567 17 two two CD cord-015021-pol2qm74 6567 18 groups group NNS cord-015021-pol2qm74 6567 19 : : : cord-015021-pol2qm74 6567 20 control control NNP cord-015021-pol2qm74 6567 21 group group NN cord-015021-pol2qm74 6567 22 ( ( -LRB- cord-015021-pol2qm74 6567 23 Objective Objective NNP cord-015021-pol2qm74 6567 24 of of IN cord-015021-pol2qm74 6567 25 study study NN cord-015021-pol2qm74 6567 26 . . . cord-015021-pol2qm74 6568 1 The the DT cord-015021-pol2qm74 6568 2 goal goal NN cord-015021-pol2qm74 6568 3 of of IN cord-015021-pol2qm74 6568 4 this this DT cord-015021-pol2qm74 6568 5 study study NN cord-015021-pol2qm74 6568 6 was be VBD cord-015021-pol2qm74 6568 7 to to TO cord-015021-pol2qm74 6568 8 prove prove VB cord-015021-pol2qm74 6568 9 the the DT cord-015021-pol2qm74 6568 10 necessity necessity NN cord-015021-pol2qm74 6568 11 of of IN cord-015021-pol2qm74 6568 12 thymus thymus NN cord-015021-pol2qm74 6568 13 derived derive VBN cord-015021-pol2qm74 6568 14 immunomodulators immunomodulator NNS cord-015021-pol2qm74 6568 15 treatment treatment NN cord-015021-pol2qm74 6568 16 in in IN cord-015021-pol2qm74 6568 17 acute acute JJ cord-015021-pol2qm74 6568 18 period period NN cord-015021-pol2qm74 6568 19 of of IN cord-015021-pol2qm74 6568 20 infantine infantine NN cord-015021-pol2qm74 6568 21 sepsis sepsis NN cord-015021-pol2qm74 6568 22 , , , cord-015021-pol2qm74 6568 23 Materials material NNS cord-015021-pol2qm74 6568 24 and and CC cord-015021-pol2qm74 6568 25 methods method NNS cord-015021-pol2qm74 6568 26 . . . cord-015021-pol2qm74 6569 1 Immune immune JJ cord-015021-pol2qm74 6569 2 status status NN cord-015021-pol2qm74 6569 3 was be VBD cord-015021-pol2qm74 6569 4 investigated investigate VBN cord-015021-pol2qm74 6569 5 in in IN cord-015021-pol2qm74 6569 6 11O 11o JJ cord-015021-pol2qm74 6569 7 infants infant NNS cord-015021-pol2qm74 6569 8 . . . cord-015021-pol2qm74 6570 1 Clinical clinical JJ cord-015021-pol2qm74 6570 2 conditions condition NNS cord-015021-pol2qm74 6570 3 of of IN cord-015021-pol2qm74 6570 4 children child NNS cord-015021-pol2qm74 6570 5 were be VBD cord-015021-pol2qm74 6570 6 defined define VBN cord-015021-pol2qm74 6570 7 by by IN cord-015021-pol2qm74 6570 8 syndrome syndrome NN cord-015021-pol2qm74 6570 9 of of IN cord-015021-pol2qm74 6570 10 multiple multiple JJ cord-015021-pol2qm74 6570 11 polyorgan]c polyorgan]c NNP cord-015021-pol2qm74 6570 12 insufficiency insufficiency NN cord-015021-pol2qm74 6570 13 . . . cord-015021-pol2qm74 6571 1 The the DT cord-015021-pol2qm74 6571 2 heaviness heaviness NN cord-015021-pol2qm74 6571 3 nf nf NN cord-015021-pol2qm74 6571 4 condition condition NN cord-015021-pol2qm74 6571 5 was be VBD cord-015021-pol2qm74 6571 6 estimated estimate VBN cord-015021-pol2qm74 6571 7 as as IN cord-015021-pol2qm74 6571 8 the the DT cord-015021-pol2qm74 6571 9 sum sum NN cord-015021-pol2qm74 6571 10 of of IN cord-015021-pol2qm74 6571 11 points point NNS cord-015021-pol2qm74 6571 12 according accord VBG cord-015021-pol2qm74 6571 13 to to IN cord-015021-pol2qm74 6571 14 efforts effort NNS cord-015021-pol2qm74 6571 15 needed need VBN cord-015021-pol2qm74 6571 16 to to TO cord-015021-pol2qm74 6571 17 restore restore VB cord-015021-pol2qm74 6571 18 of of IN cord-015021-pol2qm74 6571 19 basic basic JJ cord-015021-pol2qm74 6571 20 living living NN cord-015021-pol2qm74 6571 21 functions function NNS cord-015021-pol2qm74 6571 22 -respiration -respiration NN cord-015021-pol2qm74 6571 23 , , , cord-015021-pol2qm74 6571 24 hemodynamJcs hemodynamJcs NNP cord-015021-pol2qm74 6571 25 , , , cord-015021-pol2qm74 6571 26 hemocoagulatlon hemocoagulatlon NNP cord-015021-pol2qm74 6571 27 , , , cord-015021-pol2qm74 6571 28 metabolism metabolism NN cord-015021-pol2qm74 6571 29 , , , cord-015021-pol2qm74 6571 30 functions function NNS cord-015021-pol2qm74 6571 31 of of IN cord-015021-pol2qm74 6571 32 liver liver NN cord-015021-pol2qm74 6571 33 and and CC cord-015021-pol2qm74 6571 34 kidneys kidney NNS cord-015021-pol2qm74 6571 35 . . . cord-015021-pol2qm74 6572 1 It -PRON- PRP cord-015021-pol2qm74 6572 2 was be VBD cord-015021-pol2qm74 6572 3 expressed express VBN cord-015021-pol2qm74 6572 4 in in IN cord-015021-pol2qm74 6572 5 form form NN cord-015021-pol2qm74 6572 6 of of IN cord-015021-pol2qm74 6572 7 clinic clinic NN cord-015021-pol2qm74 6572 8 condition condition NN cord-015021-pol2qm74 6572 9 classes class NNS cord-015021-pol2qm74 6572 10 from from IN cord-015021-pol2qm74 6572 11 1 1 CD cord-015021-pol2qm74 6572 12 to to IN cord-015021-pol2qm74 6572 13 4 4 CD cord-015021-pol2qm74 6572 14 . . . cord-015021-pol2qm74 6573 1 Results result NNS cord-015021-pol2qm74 6573 2 . . . cord-015021-pol2qm74 6574 1 It -PRON- PRP cord-015021-pol2qm74 6574 2 was be VBD cord-015021-pol2qm74 6574 3 found find VBN cord-015021-pol2qm74 6574 4 that that IN cord-015021-pol2qm74 6574 5 in in IN cord-015021-pol2qm74 6574 6 100 100 CD cord-015021-pol2qm74 6574 7 % % NN cord-015021-pol2qm74 6574 8 of of IN cord-015021-pol2qm74 6574 9 infants infant NNS cord-015021-pol2qm74 6574 10 with with IN cord-015021-pol2qm74 6574 11 3 3 CD cord-015021-pol2qm74 6574 12 - - SYM cord-015021-pol2qm74 6574 13 4 4 CD cord-015021-pol2qm74 6574 14 classes class NNS cord-015021-pol2qm74 6574 15 of of IN cord-015021-pol2qm74 6574 16 heaviness heaviness NN cord-015021-pol2qm74 6574 17 immunode[iciency immunode[iciency , cord-015021-pol2qm74 6574 18 took take VBD cord-015021-pol2qm74 6574 19 place place NN cord-015021-pol2qm74 6574 20 simultaneously simultaneously RB cord-015021-pol2qm74 6574 21 with with IN cord-015021-pol2qm74 6574 22 II II NNP cord-015021-pol2qm74 6574 23 and and CC cord-015021-pol2qm74 6574 24 III iii CD cord-015021-pol2qm74 6574 25 stages stage NNS cord-015021-pol2qm74 6574 26 of of IN cord-015021-pol2qm74 6574 27 hemocoagulattve hemocoagulattve NNP cord-015021-pol2qm74 6574 28 syndrome syndrome NN cord-015021-pol2qm74 6574 29 . . . cord-015021-pol2qm74 6575 1 Amounts amount NNS cord-015021-pol2qm74 6575 2 of of IN cord-015021-pol2qm74 6575 3 T t NN cord-015021-pol2qm74 6575 4 cells cell NNS cord-015021-pol2qm74 6575 5 and and CC cord-015021-pol2qm74 6575 6 T t NN cord-015021-pol2qm74 6575 7 helpers helper NNS cord-015021-pol2qm74 6575 8 were be VBD cord-015021-pol2qm74 6575 9 decreased decrease VBN cord-015021-pol2qm74 6575 10 more more JJR cord-015021-pol2qm74 6575 11 then then RB cord-015021-pol2qm74 6575 12 2 2 CD cord-015021-pol2qm74 6575 13 times time NNS cord-015021-pol2qm74 6575 14 , , , cord-015021-pol2qm74 6575 15 ratio ratio NN cord-015021-pol2qm74 6575 16 Th Th NNP cord-015021-pol2qm74 6575 17 / / SYM cord-015021-pol2qm74 6575 18 Ts Ts NNP cord-015021-pol2qm74 6575 19 was be VBD cord-015021-pol2qm74 6575 20 reduced reduce VBN cord-015021-pol2qm74 6575 21 to to IN cord-015021-pol2qm74 6575 22 1.5 1.5 CD cord-015021-pol2qm74 6575 23 or or CC cord-015021-pol2qm74 6575 24 lower low JJR cord-015021-pol2qm74 6575 25 . . . cord-015021-pol2qm74 6576 1 Concentration concentration NN cord-015021-pol2qm74 6576 2 of of IN cord-015021-pol2qm74 6576 3 lgG lgG NNP cord-015021-pol2qm74 6576 4 and and CC cord-015021-pol2qm74 6576 5 IgAwas IgAwas NNP cord-015021-pol2qm74 6576 6 reduced reduce VBD cord-015021-pol2qm74 6576 7 almost almost RB cord-015021-pol2qm74 6576 8 a a DT cord-015021-pol2qm74 6576 9 hull hull NN cord-015021-pol2qm74 6576 10 in in IN cord-015021-pol2qm74 6576 11 comparison comparison NN cord-015021-pol2qm74 6576 12 to to TO cord-015021-pol2qm74 6576 13 control control VB cord-015021-pol2qm74 6576 14 . . . cord-015021-pol2qm74 6577 1 Phagocytic phagocytic JJ cord-015021-pol2qm74 6577 2 and and CC cord-015021-pol2qm74 6577 3 metabolic metabolic JJ cord-015021-pol2qm74 6577 4 activities activity NNS cord-015021-pol2qm74 6578 1 nf nf NNP cord-015021-pol2qm74 6578 2 neutrophils neutrophil NNS cord-015021-pol2qm74 6578 3 were be VBD cord-015021-pol2qm74 6578 4 depressed depressed JJ cord-015021-pol2qm74 6578 5 . . . cord-015021-pol2qm74 6579 1 Complement complement JJ cord-015021-pol2qm74 6579 2 system system NN cord-015021-pol2qm74 6579 3 state state NN cord-015021-pol2qm74 6579 4 was be VBD cord-015021-pol2qm74 6579 5 changed change VBN cord-015021-pol2qm74 6579 6 : : : cord-015021-pol2qm74 6579 7 the the DT cord-015021-pol2qm74 6579 8 functional functional JJ cord-015021-pol2qm74 6579 9 activity activity NN cord-015021-pol2qm74 6579 10 of of IN cord-015021-pol2qm74 6579 11 the the DT cord-015021-pol2qm74 6579 12 alternative alternative JJ cord-015021-pol2qm74 6579 13 pathway pathway NN cord-015021-pol2qm74 6579 14 factors factor NNS cord-015021-pol2qm74 6579 15 B b NN cord-015021-pol2qm74 6579 16 , , , cord-015021-pol2qm74 6579 17 D d NN cord-015021-pol2qm74 6579 18 and and CC cord-015021-pol2qm74 6579 19 the the DT cord-015021-pol2qm74 6579 20 level level NN cord-015021-pol2qm74 6579 21 or or CC cord-015021-pol2qm74 6579 22 C3a C3a NNP cord-015021-pol2qm74 6579 23 subcomponent subcomponent NN cord-015021-pol2qm74 6579 24 were be VBD cord-015021-pol2qm74 6579 25 increased increase VBN cord-015021-pol2qm74 6579 26 but but CC cord-015021-pol2qm74 6579 27 the the DT cord-015021-pol2qm74 6579 28 level level NN cord-015021-pol2qm74 6579 29 of of IN cord-015021-pol2qm74 6579 30 C2 C2 NNP cord-015021-pol2qm74 6579 31 , , , cord-015021-pol2qm74 6579 32 C3 C3 NNP cord-015021-pol2qm74 6579 33 , , , cord-015021-pol2qm74 6579 34 , , , cord-015021-pol2qm74 6579 35 C4 C4 NNP cord-015021-pol2qm74 6579 36 and and CC cord-015021-pol2qm74 6579 37 C5 C5 NNP cord-015021-pol2qm74 6579 38 components component NNS cord-015021-pol2qm74 6579 39 of of IN cord-015021-pol2qm74 6579 40 the the DT cord-015021-pol2qm74 6579 41 classic classic JJ cord-015021-pol2qm74 6579 42 pathway pathway NN cord-015021-pol2qm74 6579 43 were be VBD cord-015021-pol2qm74 6579 44 decreased decrease VBN cord-015021-pol2qm74 6579 45 . . . cord-015021-pol2qm74 6580 1 During during IN cord-015021-pol2qm74 6580 2 the the DT cord-015021-pol2qm74 6580 3 development development NN cord-015021-pol2qm74 6580 4 of of IN cord-015021-pol2qm74 6580 5 coagnlopathy coagnlopathy NNP cord-015021-pol2qm74 6580 6 the the DT cord-015021-pol2qm74 6580 7 direct direct JJ cord-015021-pol2qm74 6580 8 correlation correlation NN cord-015021-pol2qm74 6580 9 between between IN cord-015021-pol2qm74 6580 10 CHSO CHSO NNS cord-015021-pol2qm74 6580 11 , , , cord-015021-pol2qm74 6580 12 levels level NNS cord-015021-pol2qm74 6580 13 of of IN cord-015021-pol2qm74 6580 14 plasminogen plasminogen NN cord-015021-pol2qm74 6580 15 and and CC cord-015021-pol2qm74 6580 16 antithrombine antithrombine NNP cord-015021-pol2qm74 6580 17 III III NNP cord-015021-pol2qm74 6580 18 was be VBD cord-015021-pol2qm74 6580 19 found find VBN cord-015021-pol2qm74 6580 20 . . . cord-015021-pol2qm74 6581 1 In in IN cord-015021-pol2qm74 6581 2 greater great JJR cord-015021-pol2qm74 6581 3 extent extent NN cord-015021-pol2qm74 6581 4 the the DT cord-015021-pol2qm74 6581 5 function function NN cord-015021-pol2qm74 6581 6 of of IN cord-015021-pol2qm74 6581 7 immune immune JJ cord-015021-pol2qm74 6581 8 system system NN cord-015021-pol2qm74 6581 9 was be VBD cord-015021-pol2qm74 6581 10 disodered disodere VBN cord-015021-pol2qm74 6581 11 in in IN cord-015021-pol2qm74 6581 12 accordance accordance NN cord-015021-pol2qm74 6581 13 with with IN cord-015021-pol2qm74 6581 14 2 2 CD cord-015021-pol2qm74 6581 15 point point NN cord-015021-pol2qm74 6581 16 metabolic metabolic JJ cord-015021-pol2qm74 6581 17 violations violation NNS cord-015021-pol2qm74 6581 18 and and CC cord-015021-pol2qm74 6581 19 hemocoagulative hemocoagulative JJ cord-015021-pol2qm74 6581 20 disturbances disturbance NNS cord-015021-pol2qm74 6581 21 considered consider VBN cord-015021-pol2qm74 6581 22 as as IN cord-015021-pol2qm74 6581 23 disseminated disseminate VBN cord-015021-pol2qm74 6581 24 inmtravaseular inmtravaseular JJ cord-015021-pol2qm74 6581 25 clotting clotting NN cord-015021-pol2qm74 6581 26 syndrome syndrome NN cord-015021-pol2qm74 6581 27 on on IN cord-015021-pol2qm74 6581 28 II II NNP cord-015021-pol2qm74 6581 29 or or CC cord-015021-pol2qm74 6581 30 IlI ili NN cord-015021-pol2qm74 6581 31 stages stage NNS cord-015021-pol2qm74 6581 32 . . . cord-015021-pol2qm74 6582 1 Conclusions conclusion NNS cord-015021-pol2qm74 6582 2 . . . cord-015021-pol2qm74 6583 1 The the DT cord-015021-pol2qm74 6583 2 rehabilitation rehabilitation NN cord-015021-pol2qm74 6583 3 of of IN cord-015021-pol2qm74 6583 4 the the DT cord-015021-pol2qm74 6583 5 immune immune JJ cord-015021-pol2qm74 6583 6 system system NN cord-015021-pol2qm74 6583 7 functions function NNS cord-015021-pol2qm74 6583 8 was be VBD cord-015021-pol2qm74 6583 9 promoted promote VBN cord-015021-pol2qm74 6583 10 by by IN cord-015021-pol2qm74 6583 11 taetivine taetivine NNP cord-015021-pol2qm74 6583 12 and and CC cord-015021-pol2qm74 6583 13 thymaline thymaline NN cord-015021-pol2qm74 6583 14 in in IN cord-015021-pol2qm74 6583 15 doses dose NNS cord-015021-pol2qm74 6583 16 of of IN cord-015021-pol2qm74 6583 17 I-3 I-3 NNP cord-015021-pol2qm74 6583 18 mcg mcg NNP cord-015021-pol2qm74 6583 19 / / SYM cord-015021-pol2qm74 6583 20 kg kg NNP cord-015021-pol2qm74 6583 21 per per IN cord-015021-pol2qm74 6583 22 day day NN cord-015021-pol2qm74 6583 23 and and CC cord-015021-pol2qm74 6583 24 2 2 CD cord-015021-pol2qm74 6583 25 mg mg NNP cord-015021-pol2qm74 6583 26 / / SYM cord-015021-pol2qm74 6583 27 kg kg NN cord-015021-pol2qm74 6583 28 per per IN cord-015021-pol2qm74 6583 29 day day NN cord-015021-pol2qm74 6583 30 accordingly accordingly RB cord-015021-pol2qm74 6583 31 during during IN cord-015021-pol2qm74 6583 32 a a DT cord-015021-pol2qm74 6583 33 week week NN cord-015021-pol2qm74 6583 34 in in IN cord-015021-pol2qm74 6583 35 children child NNS cord-015021-pol2qm74 6583 36 with with IN cord-015021-pol2qm74 6583 37 3 3 CD cord-015021-pol2qm74 6583 38 -4 -4 NNS cord-015021-pol2qm74 6583 39 classes class NNS cord-015021-pol2qm74 6583 40 el el NNP cord-015021-pol2qm74 6583 41 heaviness heaviness NN cord-015021-pol2qm74 6583 42 . . . cord-015021-pol2qm74 6584 1 AIter aiter RB cord-015021-pol2qm74 6584 2 11 11 CD cord-015021-pol2qm74 6584 3 - - SYM cord-015021-pol2qm74 6584 4 14 14 CD cord-015021-pol2qm74 6584 5 days day NNS cord-015021-pol2qm74 6584 6 tactivine tactivine NNP cord-015021-pol2qm74 6584 7 had have VBD cord-015021-pol2qm74 6584 8 advantage advantage NN cord-015021-pol2qm74 6584 9 . . . cord-015021-pol2qm74 6585 1 When when WRB cord-015021-pol2qm74 6585 2 eoagulopathy eoagulopathy NNP cord-015021-pol2qm74 6585 3 took take VBD cord-015021-pol2qm74 6585 4 place place NN cord-015021-pol2qm74 6585 5 thynaalJne thynaalJne NNS cord-015021-pol2qm74 6585 6 promoted promote VBN cord-015021-pol2qm74 6585 7 restoration restoration NN cord-015021-pol2qm74 6585 8 of of IN cord-015021-pol2qm74 6585 9 ( ( -LRB- cord-015021-pol2qm74 6585 10 1 1 CD cord-015021-pol2qm74 6585 11 - - HYPH cord-015021-pol2qm74 6585 12 3)-~-D 3)-~-d CD cord-015021-pol2qm74 6585 13 - - HYPH cord-015021-pol2qm74 6585 14 glucan glucan NN cord-015021-pol2qm74 6585 15 ( ( -LRB- cord-015021-pol2qm74 6585 16 BGC BGC NNP cord-015021-pol2qm74 6585 17 ) ) -RRB- cord-015021-pol2qm74 6585 18 is be VBZ cord-015021-pol2qm74 6585 19 a a DT cord-015021-pol2qm74 6585 20 major major JJ cord-015021-pol2qm74 6585 21 cell cell NN cord-015021-pol2qm74 6585 22 wall wall NN cord-015021-pol2qm74 6585 23 compornent compornent NNP cord-015021-pol2qm74 6585 24 of of IN cord-015021-pol2qm74 6585 25 pathogenic pathogenic JJ cord-015021-pol2qm74 6585 26 fungi fungus NNS cord-015021-pol2qm74 6585 27 and and CC cord-015021-pol2qm74 6585 28 shows show VBZ cord-015021-pol2qm74 6585 29 many many JJ cord-015021-pol2qm74 6585 30 immunopharmacological immunopharmacological JJ cord-015021-pol2qm74 6585 31 activities activity NNS cord-015021-pol2qm74 6585 32 on on IN cord-015021-pol2qm74 6585 33 experimental experimental JJ cord-015021-pol2qm74 6585 34 animals animal NNS cord-015021-pol2qm74 6585 35 . . . cord-015021-pol2qm74 6586 1 LPS LPS NNP cord-015021-pol2qm74 6586 2 is be VBZ cord-015021-pol2qm74 6586 3 also also RB cord-015021-pol2qm74 6586 4 derived derive VBN cord-015021-pol2qm74 6586 5 from from IN cord-015021-pol2qm74 6586 6 gram gram JJ cord-015021-pol2qm74 6586 7 - - HYPH cord-015021-pol2qm74 6586 8 negative negative JJ cord-015021-pol2qm74 6586 9 bacteria bacteria NNS cord-015021-pol2qm74 6586 10 and and CC cord-015021-pol2qm74 6586 11 have have VBP cord-015021-pol2qm74 6586 12 in in IN cord-015021-pol2qm74 6586 13 ~ ~ NFP cord-015021-pol2qm74 6586 14 ttnomodulating ttnomodulating NN cord-015021-pol2qm74 6586 15 activities activity NNS cord-015021-pol2qm74 6586 16 on on IN cord-015021-pol2qm74 6586 17 immune immune JJ cord-015021-pol2qm74 6586 18 systems system NNS cord-015021-pol2qm74 6586 19 positively positively RB cord-015021-pol2qm74 6586 20 or or CC cord-015021-pol2qm74 6586 21 negatively negatively RB cord-015021-pol2qm74 6586 22 . . . cord-015021-pol2qm74 6587 1 Because because IN cord-015021-pol2qm74 6587 2 of of IN cord-015021-pol2qm74 6587 3 difficulty difficulty NN cord-015021-pol2qm74 6587 4 to to TO cord-015021-pol2qm74 6587 5 cure cure VB cord-015021-pol2qm74 6587 6 contaminating contaminate VBG cord-015021-pol2qm74 6587 7 LPS lp NNS cord-015021-pol2qm74 6587 8 from from IN cord-015021-pol2qm74 6587 9 BGC BGC NNP cord-015021-pol2qm74 6587 10 preparations preparation NNS cord-015021-pol2qm74 6587 11 , , , cord-015021-pol2qm74 6587 12 it -PRON- PRP cord-015021-pol2qm74 6587 13 is be VBZ cord-015021-pol2qm74 6587 14 very very RB cord-015021-pol2qm74 6587 15 hard hard JJ cord-015021-pol2qm74 6587 16 to to TO cord-015021-pol2qm74 6587 17 evaluate evaluate VB cord-015021-pol2qm74 6587 18 the the DT cord-015021-pol2qm74 6587 19 exact exact JJ cord-015021-pol2qm74 6587 20 activities activity NNS cord-015021-pol2qm74 6587 21 of of IN cord-015021-pol2qm74 6587 22 BGC BGC NNP cord-015021-pol2qm74 6587 23 . . . cord-015021-pol2qm74 6588 1 In in IN cord-015021-pol2qm74 6588 2 this this DT cord-015021-pol2qm74 6588 3 study study NN cord-015021-pol2qm74 6588 4 , , , cord-015021-pol2qm74 6588 5 we -PRON- PRP cord-015021-pol2qm74 6588 6 compared compare VBD cord-015021-pol2qm74 6588 7 the the DT cord-015021-pol2qm74 6588 8 immunological immunological JJ cord-015021-pol2qm74 6588 9 activities activity NNS cord-015021-pol2qm74 6588 10 of of IN cord-015021-pol2qm74 6588 11 LPS LPS NNP cord-015021-pol2qm74 6588 12 ans an NNS cord-015021-pol2qm74 6588 13 highly highly RB cord-015021-pol2qm74 6588 14 purified purify VBD cord-015021-pol2qm74 6588 15 BGC BGC NNP cord-015021-pol2qm74 6588 16 on on IN cord-015021-pol2qm74 6588 17 murine murine JJ cord-015021-pol2qm74 6588 18 system system NN cord-015021-pol2qm74 6588 19 . . . cord-015021-pol2qm74 6589 1 Materials material NNS cord-015021-pol2qm74 6589 2 and and CC cord-015021-pol2qm74 6589 3 Methods method NNS cord-015021-pol2qm74 6589 4 : : : cord-015021-pol2qm74 6589 5 C3H C3H NNP cord-015021-pol2qm74 6589 6 / / SYM cord-015021-pol2qm74 6589 7 HeN HeN NNS cord-015021-pol2qm74 6589 8 or or CC cord-015021-pol2qm74 6589 9 C3H c3h RB cord-015021-pol2qm74 6589 10 / / SYM cord-015021-pol2qm74 6589 11 HeJ hej NN cord-015021-pol2qm74 6589 12 mice mouse NNS cord-015021-pol2qm74 6589 13 , , , cord-015021-pol2qm74 6589 14 6 6 CD cord-015021-pol2qm74 6589 15 to to TO cord-015021-pol2qm74 6589 16 12 12 CD cord-015021-pol2qm74 6589 17 wkolds wkold NNS cord-015021-pol2qm74 6589 18 of of IN cord-015021-pol2qm74 6589 19 both both DT cord-015021-pol2qm74 6589 20 sexes sex NNS cord-015021-pol2qm74 6589 21 were be VBD cord-015021-pol2qm74 6589 22 used use VBN cord-015021-pol2qm74 6589 23 through through IN cord-015021-pol2qm74 6589 24 experiments experiment NNS cord-015021-pol2qm74 6589 25 . . . cord-015021-pol2qm74 6590 1 Highly highly RB cord-015021-pol2qm74 6590 2 purified purify VBN cord-015021-pol2qm74 6590 3 ( ( -LRB- cord-015021-pol2qm74 6590 4 1 1 CD cord-015021-pol2qm74 6590 5 - - SYM cord-015021-pol2qm74 6590 6 3 3 CD cord-015021-pol2qm74 6590 7 ) ) -RRB- cord-015021-pol2qm74 6590 8 -{5-D -{5-D HYPH cord-015021-pol2qm74 6590 9 - - HYPH cord-015021-pol2qm74 6590 10 glucan glucan JJ cord-015021-pol2qm74 6590 11 ( ( -LRB- cord-015021-pol2qm74 6590 12 Gurdran Gurdran NNP cord-015021-pol2qm74 6590 13 ; ; : cord-015021-pol2qm74 6590 14 BGC)was BGC)was NNP cord-015021-pol2qm74 6590 15 courteous courteous JJ cord-015021-pol2qm74 6590 16 gift gift NN cord-015021-pol2qm74 6590 17 from from IN cord-015021-pol2qm74 6591 1 Seikagaku Seikagaku NNP cord-015021-pol2qm74 6591 2 Kogyo Kogyo NNP cord-015021-pol2qm74 6591 3 Co. Co. NNP cord-015021-pol2qm74 6591 4 Tokyo Tokyo NNP cord-015021-pol2qm74 6591 5 , , , cord-015021-pol2qm74 6591 6 Japan Japan NNP cord-015021-pol2qm74 6591 7 and and CC cord-015021-pol2qm74 6591 8 resolved resolve VBD cord-015021-pol2qm74 6591 9 in in IN cord-015021-pol2qm74 6591 10 endotoxin endotoxin NN cord-015021-pol2qm74 6591 11 - - HYPH cord-015021-pol2qm74 6591 12 free free JJ cord-015021-pol2qm74 6591 13 ultra ultra JJ cord-015021-pol2qm74 6591 14 - - JJ cord-015021-pol2qm74 6591 15 pure pure JJ cord-015021-pol2qm74 6591 16 water water NN cord-015021-pol2qm74 6591 17 . . . cord-015021-pol2qm74 6592 1 Escherichia escherichia NN cord-015021-pol2qm74 6592 2 cell cell NN cord-015021-pol2qm74 6592 3 LPS LPS NNP cord-015021-pol2qm74 6592 4 was be VBD cord-015021-pol2qm74 6592 5 purchased purchase VBN cord-015021-pol2qm74 6592 6 from from IN cord-015021-pol2qm74 6592 7 Sigma Sigma NNP cord-015021-pol2qm74 6592 8 Chemicals Chemicals NNP cord-015021-pol2qm74 6592 9 , , , cord-015021-pol2qm74 6592 10 USA USA NNP cord-015021-pol2qm74 6592 11 . . . cord-015021-pol2qm74 6593 1 Mitogenic Mitogenic NNP cord-015021-pol2qm74 6593 2 activities activity NNS cord-015021-pol2qm74 6593 3 of of IN cord-015021-pol2qm74 6593 4 BGC BGC NNP cord-015021-pol2qm74 6593 5 or or CC cord-015021-pol2qm74 6593 6 LPS LPS NNP cord-015021-pol2qm74 6593 7 on on IN cord-015021-pol2qm74 6593 8 splenic splenic JJ cord-015021-pol2qm74 6593 9 cells cell NNS cord-015021-pol2qm74 6593 10 were be VBD cord-015021-pol2qm74 6593 11 measured measure VBN cord-015021-pol2qm74 6593 12 by by IN cord-015021-pol2qm74 6593 13 MIT MIT NNP cord-015021-pol2qm74 6593 14 dye dye NN cord-015021-pol2qm74 6593 15 assay assay NN cord-015021-pol2qm74 6593 16 . . . cord-015021-pol2qm74 6594 1 In in IN cord-015021-pol2qm74 6594 2 vitro vitro FW cord-015021-pol2qm74 6594 3 activation activation NN cord-015021-pol2qm74 6594 4 of of IN cord-015021-pol2qm74 6594 5 peritoneal peritoneal JJ cord-015021-pol2qm74 6594 6 exudate exudate NNP cord-015021-pol2qm74 6594 7 macrophage macrophage NN cord-015021-pol2qm74 6594 8 ( ( -LRB- cord-015021-pol2qm74 6594 9 PEN pen NN cord-015021-pol2qm74 6594 10 ) ) -RRB- cord-015021-pol2qm74 6594 11 have have VBP cord-015021-pol2qm74 6594 12 moniotored moniotore VBN cord-015021-pol2qm74 6594 13 by by IN cord-015021-pol2qm74 6594 14 phagocytosis phagocytosis NN cord-015021-pol2qm74 6594 15 and and CC cord-015021-pol2qm74 6594 16 intraphagocytic intraphagocytic JJ cord-015021-pol2qm74 6594 17 killing killing NN cord-015021-pol2qm74 6594 18 of of IN cord-015021-pol2qm74 6594 19 Pseudomonas Pseudomonas NNP cord-015021-pol2qm74 6594 20 aeruginosa aeruginosa NN cord-015021-pol2qm74 6594 21 ( ( -LRB- cord-015021-pol2qm74 6594 22 Z z NN cord-015021-pol2qm74 6594 23 ~ ~ NFP cord-015021-pol2qm74 6594 24 B-139 b-139 NN cord-015021-pol2qm74 6594 25 . . . cord-015021-pol2qm74 6595 1 Induction induction NN cord-015021-pol2qm74 6595 2 of of IN cord-015021-pol2qm74 6595 3 cytokine cytokine NN cord-015021-pol2qm74 6595 4 productions production NNS cord-015021-pol2qm74 6595 5 from from IN cord-015021-pol2qm74 6595 6 PEM pem NN cord-015021-pol2qm74 6595 7 or or CC cord-015021-pol2qm74 6595 8 spleen spleen NN cord-015021-pol2qm74 6595 9 cells cell NNS cord-015021-pol2qm74 6595 10 induced induce VBN cord-015021-pol2qm74 6595 11 by by IN cord-015021-pol2qm74 6595 12 BGC BGC NNP cord-015021-pol2qm74 6595 13 or or CC cord-015021-pol2qm74 6595 14 LPS LPS NNP cord-015021-pol2qm74 6595 15 were be VBD cord-015021-pol2qm74 6595 16 detected detect VBN cord-015021-pol2qm74 6595 17 by by IN cord-015021-pol2qm74 6595 18 cytotoxic cytotoxic JJ cord-015021-pol2qm74 6595 19 assay assay NN cord-015021-pol2qm74 6595 20 . . . cord-015021-pol2qm74 6596 1 Results result NNS cord-015021-pol2qm74 6596 2 and and CC cord-015021-pol2qm74 6596 3 ( ( -LRB- cord-015021-pol2qm74 6596 4 bnclnsions bnclnsion NNS cord-015021-pol2qm74 6596 5 : : : cord-015021-pol2qm74 6596 6 I i NN cord-015021-pol2qm74 6596 7 ) ) -RRB- cord-015021-pol2qm74 6597 1 In in IN cord-015021-pol2qm74 6597 2 vitro vitro FW cord-015021-pol2qm74 6597 3 cultures culture NNS cord-015021-pol2qm74 6597 4 of of IN cord-015021-pol2qm74 6597 5 PEM PEM NNP cord-015021-pol2qm74 6597 6 with with IN cord-015021-pol2qm74 6597 7 BGC BGC NNP cord-015021-pol2qm74 6597 8 have have VBP cord-015021-pol2qm74 6597 9 induced induce VBN cord-015021-pol2qm74 6597 10 enhanced enhance VBN cord-015021-pol2qm74 6597 11 phagocytic phagocytic JJ cord-015021-pol2qm74 6597 12 and and CC cord-015021-pol2qm74 6597 13 bactecidal bactecidal JJ cord-015021-pol2qm74 6597 14 activities activity NNS cord-015021-pol2qm74 6597 15 in in IN cord-015021-pol2qm74 6597 16 C3H c3h NN cord-015021-pol2qm74 6597 17 / / SYM cord-015021-pol2qm74 6597 18 HeN HeN NNS cord-015021-pol2qm74 6597 19 and and CC cord-015021-pol2qm74 6597 20 C3H c3h RB cord-015021-pol2qm74 6597 21 / / SYM cord-015021-pol2qm74 6597 22 HeJ hej NN cord-015021-pol2qm74 6597 23 mice mouse NNS cord-015021-pol2qm74 6597 24 , , , cord-015021-pol2qm74 6597 25 whereas whereas IN cord-015021-pol2qm74 6597 26 LPS LPS NNP cord-015021-pol2qm74 6597 27 only only RB cord-015021-pol2qm74 6597 28 induced induce VBD cord-015021-pol2qm74 6597 29 such such JJ cord-015021-pol2qm74 6597 30 activities activity NNS cord-015021-pol2qm74 6597 31 in in IN cord-015021-pol2qm74 6597 32 C3H c3h NN cord-015021-pol2qm74 6597 33 / / SYM cord-015021-pol2qm74 6597 34 HeN hen JJ cord-015021-pol2qm74 6597 35 mice mouse NNS cord-015021-pol2qm74 6597 36 . . . cord-015021-pol2qm74 6598 1 Most Most JJS cord-015021-pol2qm74 6598 2 effective effective JJ cord-015021-pol2qm74 6598 3 dose dose NN cord-015021-pol2qm74 6598 4 of of IN cord-015021-pol2qm74 6598 5 BGC BGC NNP cord-015021-pol2qm74 6598 6 was be VBD cord-015021-pol2qm74 6599 1 10 10 CD cord-015021-pol2qm74 6599 2 ug ug NNP cord-015021-pol2qm74 6599 3 / / SYM cord-015021-pol2qm74 6599 4 ml ml NN cord-015021-pol2qm74 6599 5 . . NNP cord-015021-pol2qm74 6599 6 2 2 LS cord-015021-pol2qm74 6599 7 ) ) -RRB- cord-015021-pol2qm74 6599 8 BGC BGC NNP cord-015021-pol2qm74 6599 9 - - HYPH cord-015021-pol2qm74 6599 10 dependent dependent JJ cord-015021-pol2qm74 6599 11 proliferative proliferative JJ cord-015021-pol2qm74 6599 12 response response NN cord-015021-pol2qm74 6599 13 of of IN cord-015021-pol2qm74 6599 14 C3H c3h NN cord-015021-pol2qm74 6599 15 / / SYM cord-015021-pol2qm74 6599 16 HeN hen NN cord-015021-pol2qm74 6599 17 splenic splenic JJ cord-015021-pol2qm74 6599 18 cells cell NNS cord-015021-pol2qm74 6599 19 was be VBD cord-015021-pol2qm74 6599 20 not not RB cord-015021-pol2qm74 6599 21 detected detect VBN cord-015021-pol2qm74 6599 22 under under IN cord-015021-pol2qm74 6599 23 the the DT cord-015021-pol2qm74 6599 24 culture culture NN cord-015021-pol2qm74 6599 25 condition condition NN cord-015021-pol2qm74 6599 26 used use VBN cord-015021-pol2qm74 6599 27 . . . cord-015021-pol2qm74 6600 1 3 3 LS cord-015021-pol2qm74 6600 2 ) ) -RRB- cord-015021-pol2qm74 6600 3 Induction induction NN cord-015021-pol2qm74 6600 4 of of IN cord-015021-pol2qm74 6600 5 TNF~ tnf~ CD cord-015021-pol2qm74 6600 6 prodction prodction NN cord-015021-pol2qm74 6600 7 was be VBD cord-015021-pol2qm74 6600 8 apparently apparently RB cord-015021-pol2qm74 6600 9 observed observe VBN cord-015021-pol2qm74 6600 10 in in IN cord-015021-pol2qm74 6600 11 BGC BGC NNP cord-015021-pol2qm74 6600 12 - - HYPH cord-015021-pol2qm74 6600 13 stimulated stimulate VBN cord-015021-pol2qm74 6600 14 C3H c3h JJ cord-015021-pol2qm74 6600 15 / / SYM cord-015021-pol2qm74 6600 16 HeJ hej NN cord-015021-pol2qm74 6600 17 PD4 PD4 NNP cord-015021-pol2qm74 6600 18 cultures culture NNS cord-015021-pol2qm74 6600 19 , , , cord-015021-pol2qm74 6600 20 but but CC cord-015021-pol2qm74 6600 21 not not RB cord-015021-pol2qm74 6600 22 in in IN cord-015021-pol2qm74 6600 23 LPS LPS NNP cord-015021-pol2qm74 6600 24 stimulated stimulate VBD cord-015021-pol2qm74 6600 25 one one CD cord-015021-pol2qm74 6600 26 . . . cord-015021-pol2qm74 6601 1 These these DT cord-015021-pol2qm74 6601 2 findings finding NNS cord-015021-pol2qm74 6601 3 indicate indicate VBP cord-015021-pol2qm74 6601 4 that that IN cord-015021-pol2qm74 6601 5 activation activation NN cord-015021-pol2qm74 6601 6 mechanisms mechanism NNS cord-015021-pol2qm74 6601 7 of of IN cord-015021-pol2qm74 6601 8 Pr94 Pr94 NNP cord-015021-pol2qm74 6601 9 and and CC cord-015021-pol2qm74 6601 10 splenic splenic JJ cord-015021-pol2qm74 6601 11 cells cell NNS cord-015021-pol2qm74 6601 12 by by IN cord-015021-pol2qm74 6601 13 BGC BGC NNP cord-015021-pol2qm74 6601 14 are be VBP cord-015021-pol2qm74 6601 15 different different JJ cord-015021-pol2qm74 6601 16 from from IN cord-015021-pol2qm74 6601 17 that that DT cord-015021-pol2qm74 6601 18 by by IN cord-015021-pol2qm74 6601 19 LPS lp NNS cord-015021-pol2qm74 6601 20 . . . cord-015021-pol2qm74 6602 1 To to TO cord-015021-pol2qm74 6602 2 investigate investigate VB cord-015021-pol2qm74 6602 3 the the DT cord-015021-pol2qm74 6602 4 BSC BSC NNP cord-015021-pol2qm74 6602 5 - - HYPH cord-015021-pol2qm74 6602 6 induced induce VBN cord-015021-pol2qm74 6602 7 P~4 P~4 NNP cord-015021-pol2qm74 6602 8 activation activation NN cord-015021-pol2qm74 6602 9 , , , cord-015021-pol2qm74 6602 10 intracellular intracellular JJ cord-015021-pol2qm74 6602 11 signaling signal VBG cord-015021-pol2qm74 6602 12 pathways pathway NNS cord-015021-pol2qm74 6602 13 of of IN cord-015021-pol2qm74 6602 14 P~4 P~4 NNP cord-015021-pol2qm74 6602 15 by by IN cord-015021-pol2qm74 6602 16 BGC BGC NNP cord-015021-pol2qm74 6602 17 - - HYPH cord-015021-pol2qm74 6602 18 stimulation stimulation NN cord-015021-pol2qm74 6602 19 are be VBP cord-015021-pol2qm74 6602 20 under under IN cord-015021-pol2qm74 6602 21 consideration consideration NN cord-015021-pol2qm74 6602 22 . . . cord-015021-pol2qm74 6603 1 Yamagami Yamagami NNP cord-015021-pol2qm74 6603 2 K K NNP cord-015021-pol2qm74 6603 3 , , , cord-015021-pol2qm74 6603 4 Uedono Uedono NNP cord-015021-pol2qm74 6603 5 Y Y NNP cord-015021-pol2qm74 6603 6 , , , cord-015021-pol2qm74 6603 7 Kawakami Kawakami NNP cord-015021-pol2qm74 6603 8 K K NNP cord-015021-pol2qm74 6603 9 , , , cord-015021-pol2qm74 6603 10 Kitazawa Kitazawa NNP cord-015021-pol2qm74 6603 11 Y Y NNP cord-015021-pol2qm74 6603 12 and and CC cord-015021-pol2qm74 6603 13 Tanaka Tanaka NNP cord-015021-pol2qm74 6603 14 T T NNP cord-015021-pol2qm74 6604 1 According accord VBG cord-015021-pol2qm74 6604 2 to to IN cord-015021-pol2qm74 6604 3 the the DT cord-015021-pol2qm74 6604 4 latest late JJS cord-015021-pol2qm74 6604 5 reports report NNS cord-015021-pol2qm74 6604 6 of of IN cord-015021-pol2qm74 6604 7 use use NN cord-015021-pol2qm74 6604 8 of of IN cord-015021-pol2qm74 6604 9 IL-2 IL-2 NNP cord-015021-pol2qm74 6604 10 in in IN cord-015021-pol2qm74 6604 11 a a DT cord-015021-pol2qm74 6604 12 burned burn VBN cord-015021-pol2qm74 6604 13 - - HYPH cord-015021-pol2qm74 6604 14 sepsis sepsis NN cord-015021-pol2qm74 6604 15 model model NN cord-015021-pol2qm74 6604 16 , , , cord-015021-pol2qm74 6604 17 the the DT cord-015021-pol2qm74 6604 18 dose dose NN cord-015021-pol2qm74 6604 19 was be VBD cord-015021-pol2qm74 6604 20 too too RB cord-015021-pol2qm74 6604 21 high high JJ cord-015021-pol2qm74 6604 22 to to TO cord-015021-pol2qm74 6604 23 adjust adjust VB cord-015021-pol2qm74 6604 24 for for IN cord-015021-pol2qm74 6604 25 human human JJ cord-015021-pol2qm74 6604 26 therapy therapy NN cord-015021-pol2qm74 6604 27 . . . cord-015021-pol2qm74 6605 1 Adoptive adoptive JJ cord-015021-pol2qm74 6605 2 transfer transfer NN cord-015021-pol2qm74 6605 3 of of IN cord-015021-pol2qm74 6605 4 L L NNP cord-015021-pol2qm74 6605 5 ~ ~ CD cord-015021-pol2qm74 6605 6 ymphokine ymphokine NN cord-015021-pol2qm74 6605 7 - - HYPH cord-015021-pol2qm74 6605 8 activated activate VBN cord-015021-pol2qm74 6605 9 killer killer NN cord-015021-pol2qm74 6605 10 ( ( -LRB- cord-015021-pol2qm74 6605 11 LAK LAK NNP cord-015021-pol2qm74 6605 12 ) ) -RRB- cord-015021-pol2qm74 6605 13 cells cell NNS cord-015021-pol2qm74 6605 14 has have VBZ cord-015021-pol2qm74 6605 15 been be VBN cord-015021-pol2qm74 6605 16 demonstrated demonstrate VBN cord-015021-pol2qm74 6605 17 as as IN cord-015021-pol2qm74 6605 18 a a DT cord-015021-pol2qm74 6605 19 means means NN cord-015021-pol2qm74 6605 20 of of IN cord-015021-pol2qm74 6605 21 enhancing enhance VBG cord-015021-pol2qm74 6605 22 therapy therapy NN cord-015021-pol2qm74 6605 23 in in IN cord-015021-pol2qm74 6605 24 malignant malignant JJ cord-015021-pol2qm74 6605 25 tumors tumor NNS cord-015021-pol2qm74 6605 26 . . . cord-015021-pol2qm74 6606 1 We -PRON- PRP cord-015021-pol2qm74 6606 2 therefore therefore RB cord-015021-pol2qm74 6606 3 attempt attempt VBP cord-015021-pol2qm74 6606 4 to to TO cord-015021-pol2qm74 6606 5 use use VB cord-015021-pol2qm74 6606 6 LAK LAK NNP cord-015021-pol2qm74 6606 7 therapy therapy NN cord-015021-pol2qm74 6606 8 on on IN cord-015021-pol2qm74 6606 9 burned burn VBN cord-015021-pol2qm74 6606 10 - - HYPH cord-015021-pol2qm74 6606 11 infected infect VBN cord-015021-pol2qm74 6606 12 mice mouse NNS cord-015021-pol2qm74 6606 13 instead instead RB cord-015021-pol2qm74 6606 14 of of IN cord-015021-pol2qm74 6606 15 IL-2 IL-2 NNP cord-015021-pol2qm74 6606 16 . . . cord-015021-pol2qm74 6607 1 Under under IN cord-015021-pol2qm74 6607 2 anesthesia anesthesia NN cord-015021-pol2qm74 6607 3 , , , cord-015021-pol2qm74 6607 4 8-weekold 8-weekold CD cord-015021-pol2qm74 6607 5 male male JJ cord-015021-pol2qm74 6607 6 C3H c3h NN cord-015021-pol2qm74 6607 7 - - HYPH cord-015021-pol2qm74 6607 8 Hej Hej NNP cord-015021-pol2qm74 6607 9 mice mouse NNS cord-015021-pol2qm74 6607 10 were be VBD cord-015021-pol2qm74 6607 11 subjected subject VBN cord-015021-pol2qm74 6607 12 to to IN cord-015021-pol2qm74 6607 13 a a DT cord-015021-pol2qm74 6607 14 20 20 CD cord-015021-pol2qm74 6607 15 % % NN cord-015021-pol2qm74 6607 16 scald scald NN cord-015021-pol2qm74 6607 17 or or CC cord-015021-pol2qm74 6607 18 sham sham NN cord-015021-pol2qm74 6607 19 burn burn NN cord-015021-pol2qm74 6607 20 and and CC cord-015021-pol2qm74 6607 21 then then RB cord-015021-pol2qm74 6607 22 resuscitated resuscitate VBD cord-015021-pol2qm74 6607 23 . . . cord-015021-pol2qm74 6608 1 Sham Sham NNP cord-015021-pol2qm74 6608 2 burned burn VBD cord-015021-pol2qm74 6608 3 mice mouse NNS cord-015021-pol2qm74 6608 4 served serve VBD cord-015021-pol2qm74 6608 5 as as IN cord-015021-pol2qm74 6608 6 controls control NNS cord-015021-pol2qm74 6608 7 . . . cord-015021-pol2qm74 6609 1 Scald scald VB cord-015021-pol2qm74 6609 2 burn burn VB cord-015021-pol2qm74 6610 1 mice mouse NNS cord-015021-pol2qm74 6610 2 were be VBD cord-015021-pol2qm74 6610 3 subjected subject VBN cord-015021-pol2qm74 6610 4 to to IN cord-015021-pol2qm74 6610 5 peritonitis peritonitis NN cord-015021-pol2qm74 6610 6 by by IN cord-015021-pol2qm74 6610 7 intraperitoneal intraperitoneal JJ cord-015021-pol2qm74 6610 8 innoculation innoculation NN cord-015021-pol2qm74 6610 9 of of IN cord-015021-pol2qm74 6610 10 105 105 CD cord-015021-pol2qm74 6610 11 organisms organism NNS cord-015021-pol2qm74 6610 12 of of IN cord-015021-pol2qm74 6610 13 P. P. NNP cord-015021-pol2qm74 6610 14 aeruginosa aeruginosa NNP cord-015021-pol2qm74 6610 15 24 24 CD cord-015021-pol2qm74 6610 16 hr hr NN cord-015021-pol2qm74 6610 17 after after IN cord-015021-pol2qm74 6610 18 burn burn NN cord-015021-pol2qm74 6610 19 . . . cord-015021-pol2qm74 6611 1 Burned burn VBN cord-015021-pol2qm74 6611 2 - - HYPH cord-015021-pol2qm74 6611 3 infected infect VBN cord-015021-pol2qm74 6611 4 - - HYPH cord-015021-pol2qm74 6611 5 mice mouse NNS cord-015021-pol2qm74 6611 6 were be VBD cord-015021-pol2qm74 6611 7 divided divide VBN cord-015021-pol2qm74 6611 8 into into IN cord-015021-pol2qm74 6611 9 two two CD cord-015021-pol2qm74 6611 10 groups group NNS cord-015021-pol2qm74 6611 11 . . . cord-015021-pol2qm74 6612 1 One one CD cord-015021-pol2qm74 6612 2 group group NN cord-015021-pol2qm74 6612 3 had have VBD cord-015021-pol2qm74 6612 4 no no DT cord-015021-pol2qm74 6612 5 further further JJ cord-015021-pol2qm74 6612 6 treatment treatment NN cord-015021-pol2qm74 6612 7 , , , cord-015021-pol2qm74 6612 8 and and CC cord-015021-pol2qm74 6612 9 the the DT cord-015021-pol2qm74 6612 10 other other JJ cord-015021-pol2qm74 6612 11 group group NN cord-015021-pol2qm74 6612 12 received receive VBD cord-015021-pol2qm74 6612 13 LAK LAK NNP cord-015021-pol2qm74 6612 14 cells cell NNS cord-015021-pol2qm74 6612 15 ( ( -LRB- cord-015021-pol2qm74 6612 16 2x105 2x105 CD cord-015021-pol2qm74 6612 17 ) ) -RRB- cord-015021-pol2qm74 6612 18 intraperitonelly intraperitonelly NN cord-015021-pol2qm74 6612 19 after after IN cord-015021-pol2qm74 6612 20 septic septic JJ cord-015021-pol2qm74 6612 21 challenge challenge NN cord-015021-pol2qm74 6612 22 . . . cord-015021-pol2qm74 6613 1 The the DT cord-015021-pol2qm74 6613 2 mice mouse NNS cord-015021-pol2qm74 6613 3 were be VBD cord-015021-pol2qm74 6613 4 scored score VBN cord-015021-pol2qm74 6613 5 for for IN cord-015021-pol2qm74 6613 6 survival survival NN cord-015021-pol2qm74 6613 7 daily daily RB cord-015021-pol2qm74 6613 8 . . . cord-015021-pol2qm74 6614 1 On on IN cord-015021-pol2qm74 6614 2 day day NN cord-015021-pol2qm74 6614 3 7 7 CD cord-015021-pol2qm74 6614 4 after after IN cord-015021-pol2qm74 6614 5 burn burn NN cord-015021-pol2qm74 6614 6 , , , cord-015021-pol2qm74 6614 7 Using use VBG cord-015021-pol2qm74 6614 8 Moabs Moabs NNPS cord-015021-pol2qm74 6614 9 dual dual JJ cord-015021-pol2qm74 6614 10 - - HYPH cord-015021-pol2qm74 6614 11 color color NN cord-015021-pol2qm74 6614 12 flow flow NN cord-015021-pol2qm74 6614 13 cytometry cytometry NN cord-015021-pol2qm74 6614 14 , , , cord-015021-pol2qm74 6614 15 we -PRON- PRP cord-015021-pol2qm74 6614 16 studied study VBD cord-015021-pol2qm74 6614 17 lymphocyte lymphocyte NN cord-015021-pol2qm74 6614 18 expression expression NN cord-015021-pol2qm74 6614 19 in in IN cord-015021-pol2qm74 6614 20 mice mouse NNS cord-015021-pol2qm74 6614 21 with with IN cord-015021-pol2qm74 6614 22 use use NN cord-015021-pol2qm74 6614 23 of of IN cord-015021-pol2qm74 6614 24 blood blood NN cord-015021-pol2qm74 6614 25 and and CC cord-015021-pol2qm74 6614 26 spleen spleen NNS cord-015021-pol2qm74 6614 27 . . . cord-015021-pol2qm74 6615 1 Simultaneousely Simultaneousely NNP cord-015021-pol2qm74 6615 2 we -PRON- PRP cord-015021-pol2qm74 6615 3 studied study VBD cord-015021-pol2qm74 6615 4 the the DT cord-015021-pol2qm74 6615 5 alteration alteration NN cord-015021-pol2qm74 6615 6 of of IN cord-015021-pol2qm74 6615 7 IL-1 IL-1 NNP cord-015021-pol2qm74 6615 8 and and CC cord-015021-pol2qm74 6615 9 IL-6 IL-6 NNP cord-015021-pol2qm74 6615 10 in in IN cord-015021-pol2qm74 6615 11 their -PRON- PRP$ cord-015021-pol2qm74 6615 12 serum serum NN cord-015021-pol2qm74 6615 13 using use VBG cord-015021-pol2qm74 6615 14 immunoassy immunoassy NN cord-015021-pol2qm74 6615 15 kits kit NNS cord-015021-pol2qm74 6615 16 . . . cord-015021-pol2qm74 6616 1 Sham Sham NNP cord-015021-pol2qm74 6616 2 burned burn VBD cord-015021-pol2qm74 6616 3 animals animal NNS cord-015021-pol2qm74 6616 4 had have VBD cord-015021-pol2qm74 6616 5 no no DT cord-015021-pol2qm74 6616 6 mortality mortality NN cord-015021-pol2qm74 6616 7 . . . cord-015021-pol2qm74 6617 1 The the DT cord-015021-pol2qm74 6617 2 mortality mortality NN cord-015021-pol2qm74 6617 3 of of IN cord-015021-pol2qm74 6617 4 the the DT cord-015021-pol2qm74 6617 5 LAK LAK NNP cord-015021-pol2qm74 6617 6 - - HYPH cord-015021-pol2qm74 6617 7 treated treat VBN cord-015021-pol2qm74 6617 8 mice mouse NNS cord-015021-pol2qm74 6617 9 was be VBD cord-015021-pol2qm74 6617 10 significantly significantly RB cord-015021-pol2qm74 6617 11 reduced reduce VBN cord-015021-pol2qm74 6617 12 when when WRB cord-015021-pol2qm74 6617 13 compared compare VBN cord-015021-pol2qm74 6617 14 with with IN cord-015021-pol2qm74 6617 15 that that DT cord-015021-pol2qm74 6617 16 of of IN cord-015021-pol2qm74 6617 17 the the DT cord-015021-pol2qm74 6617 18 burned burn VBN cord-015021-pol2qm74 6617 19 - - HYPH cord-015021-pol2qm74 6617 20 infected infect VBN cord-015021-pol2qm74 6617 21 mice mouse NNS cord-015021-pol2qm74 6617 22 . . . cord-015021-pol2qm74 6618 1 The the DT cord-015021-pol2qm74 6618 2 most most RBS cord-015021-pol2qm74 6618 3 consistent consistent JJ cord-015021-pol2qm74 6618 4 changes change NNS cord-015021-pol2qm74 6618 5 observed observe VBD cord-015021-pol2qm74 6618 6 were be VBD cord-015021-pol2qm74 6618 7 depressions depression NNS cord-015021-pol2qm74 6618 8 in in IN cord-015021-pol2qm74 6618 9 percentages percentage NNS cord-015021-pol2qm74 6618 10 of of IN cord-015021-pol2qm74 6618 11 Thyl Thyl NNP cord-015021-pol2qm74 6618 12 , , , cord-015021-pol2qm74 6618 13 2 2 CD cord-015021-pol2qm74 6618 14 positive positive JJ cord-015021-pol2qm74 6618 15 cells cell NNS cord-015021-pol2qm74 6618 16 and and CC cord-015021-pol2qm74 6618 17 a a DT cord-015021-pol2qm74 6618 18 remarkable remarkable JJ cord-015021-pol2qm74 6618 19 depression depression NN cord-015021-pol2qm74 6618 20 of of IN cord-015021-pol2qm74 6618 21 NK NK NNP cord-015021-pol2qm74 6618 22 cells cell NNS cord-015021-pol2qm74 6618 23 in in IN cord-015021-pol2qm74 6618 24 spleen spleen NN cord-015021-pol2qm74 6618 25 . . . cord-015021-pol2qm74 6619 1 After after IN cord-015021-pol2qm74 6619 2 LAK LAK NNP cord-015021-pol2qm74 6619 3 cell cell NN cord-015021-pol2qm74 6619 4 treatment treatment NN cord-015021-pol2qm74 6619 5 , , , cord-015021-pol2qm74 6619 6 those those DT cord-015021-pol2qm74 6619 7 two two CD cord-015021-pol2qm74 6619 8 percentages percentage NNS cord-015021-pol2qm74 6619 9 of of IN cord-015021-pol2qm74 6619 10 cells cell NNS cord-015021-pol2qm74 6619 11 significantly significantly RB cord-015021-pol2qm74 6619 12 increased increase VBD cord-015021-pol2qm74 6619 13 . . . cord-015021-pol2qm74 6620 1 All all PDT cord-015021-pol2qm74 6620 2 the the DT cord-015021-pol2qm74 6620 3 data datum NNS cord-015021-pol2qm74 6620 4 of of IN cord-015021-pol2qm74 6620 5 assay assay NN cord-015021-pol2qm74 6620 6 of of IN cord-015021-pol2qm74 6620 7 ILl ILl NNS cord-015021-pol2qm74 6620 8 and and CC cord-015021-pol2qm74 6620 9 [ [ -LRB- cord-015021-pol2qm74 6620 10 L L NNP cord-015021-pol2qm74 6620 11 6 6 CD cord-015021-pol2qm74 6620 12 were be VBD cord-015021-pol2qm74 6620 13 not not RB cord-015021-pol2qm74 6620 14 detected detect VBN cord-015021-pol2qm74 6620 15 on on IN cord-015021-pol2qm74 6620 16 sham sham NN cord-015021-pol2qm74 6620 17 burn burn NN cord-015021-pol2qm74 6620 18 mice mouse NNS cord-015021-pol2qm74 6620 19 serum serum NN cord-015021-pol2qm74 6620 20 . . . cord-015021-pol2qm74 6621 1 Due due IN cord-015021-pol2qm74 6621 2 to to TO cord-015021-pol2qm74 6621 3 burn burn VB cord-015021-pol2qm74 6621 4 and and CC cord-015021-pol2qm74 6621 5 septic septic JJ cord-015021-pol2qm74 6621 6 challenge challenge NN cord-015021-pol2qm74 6621 7 the the DT cord-015021-pol2qm74 6621 8 levels level NNS cord-015021-pol2qm74 6621 9 of of IN cord-015021-pol2qm74 6621 10 ILland ILland NNP cord-015021-pol2qm74 6621 11 IL IL NNP cord-015021-pol2qm74 6621 12 6 6 CD cord-015021-pol2qm74 6621 13 ( ( -LRB- cord-015021-pol2qm74 6621 14 n=6 n=6 NNP cord-015021-pol2qm74 6621 15 ) ) -RRB- cord-015021-pol2qm74 6621 16 were be VBD cord-015021-pol2qm74 6621 17 raised raise VBN cord-015021-pol2qm74 6621 18 to to IN cord-015021-pol2qm74 6621 19 45.9_+17.4 45.9_+17.4 CD cord-015021-pol2qm74 6621 20 and and CC cord-015021-pol2qm74 6621 21 3866_+1045 3866_+1045 CD cord-015021-pol2qm74 6621 22 pg pg NNP cord-015021-pol2qm74 6621 23 / / SYM cord-015021-pol2qm74 6621 24 ml ml XX cord-015021-pol2qm74 6621 25 , , , cord-015021-pol2qm74 6621 26 while while IN cord-015021-pol2qm74 6621 27 the the DT cord-015021-pol2qm74 6621 28 levels level NNS cord-015021-pol2qm74 6621 29 in in IN cord-015021-pol2qm74 6621 30 LAK LAK NNP cord-015021-pol2qm74 6621 31 treated treat VBD cord-015021-pol2qm74 6621 32 mice mouse NNS cord-015021-pol2qm74 6621 33 were be VBD cord-015021-pol2qm74 6621 34 reduced reduce VBN cord-015021-pol2qm74 6621 35 to to IN cord-015021-pol2qm74 6621 36 4.23_+2.37 4.23_+2.37 CD cord-015021-pol2qm74 6621 37 and and CC cord-015021-pol2qm74 6621 38 437_+110 437_+110 CD cord-015021-pol2qm74 6621 39 pg pg NNP cord-015021-pol2qm74 6621 40 / / SYM cord-015021-pol2qm74 6621 41 ml ml NNS cord-015021-pol2qm74 6621 42 , , , cord-015021-pol2qm74 6621 43 respectively respectively RB cord-015021-pol2qm74 6621 44 . . . cord-015021-pol2qm74 6622 1 The the DT cord-015021-pol2qm74 6622 2 results result NNS cord-015021-pol2qm74 6622 3 reported report VBN cord-015021-pol2qm74 6622 4 here here RB cord-015021-pol2qm74 6622 5 demonstrate demonstrate VBP cord-015021-pol2qm74 6622 6 that that IN cord-015021-pol2qm74 6622 7 LAK LAK NNP cord-015021-pol2qm74 6622 8 therapy therapy NN cord-015021-pol2qm74 6622 9 is be VBZ cord-015021-pol2qm74 6622 10 able able JJ cord-015021-pol2qm74 6622 11 to to TO cord-015021-pol2qm74 6622 12 improve improve VB cord-015021-pol2qm74 6622 13 cell cell NN cord-015021-pol2qm74 6622 14 - - HYPH cord-015021-pol2qm74 6622 15 mediated mediate VBN cord-015021-pol2qm74 6622 16 immunity immunity NN cord-015021-pol2qm74 6622 17 in in IN cord-015021-pol2qm74 6622 18 burned burn VBN cord-015021-pol2qm74 6622 19 - - HYPH cord-015021-pol2qm74 6622 20 infected infect VBN cord-015021-pol2qm74 6622 21 mice mouse NNS cord-015021-pol2qm74 6622 22 . . . cord-015021-pol2qm74 6623 1 This this DT cord-015021-pol2qm74 6623 2 is be VBZ cord-015021-pol2qm74 6623 3 associated associate VBN cord-015021-pol2qm74 6623 4 with with IN cord-015021-pol2qm74 6623 5 a a DT cord-015021-pol2qm74 6623 6 significantly significantly RB cord-015021-pol2qm74 6623 7 improved improve VBN cord-015021-pol2qm74 6623 8 survival survival NN cord-015021-pol2qm74 6623 9 rate rate NN cord-015021-pol2qm74 6623 10 , , , cord-015021-pol2qm74 6623 11 since since IN cord-015021-pol2qm74 6623 12 ILl ILl NNP cord-015021-pol2qm74 6623 13 has have VBZ cord-015021-pol2qm74 6623 14 been be VBN cord-015021-pol2qm74 6623 15 demonstrated demonstrate VBN cord-015021-pol2qm74 6623 16 to to TO cord-015021-pol2qm74 6623 17 mediate mediate VB cord-015021-pol2qm74 6623 18 immune immune JJ cord-015021-pol2qm74 6623 19 and and CC cord-015021-pol2qm74 6623 20 inflammatory inflammatory JJ cord-015021-pol2qm74 6623 21 responses response NNS cord-015021-pol2qm74 6623 22 . . . cord-015021-pol2qm74 6624 1 Also also RB cord-015021-pol2qm74 6624 2 a a DT cord-015021-pol2qm74 6624 3 cause cause NN cord-015021-pol2qm74 6624 4 effect effect NN cord-015021-pol2qm74 6624 5 relationship relationship NN cord-015021-pol2qm74 6624 6 between between IN cord-015021-pol2qm74 6624 7 elevated elevated JJ cord-015021-pol2qm74 6624 8 endetoxin endetoxin NN cord-015021-pol2qm74 6624 9 levels level NNS cord-015021-pol2qm74 6624 10 and and CC cord-015021-pol2qm74 6624 11 increases increase NNS cord-015021-pol2qm74 6624 12 of of IN cord-015021-pol2qm74 6624 13 [ [ -LRB- cord-015021-pol2qm74 6624 14 L6 L6 NNP cord-015021-pol2qm74 6624 15 has have VBZ cord-015021-pol2qm74 6624 16 been be VBN cord-015021-pol2qm74 6624 17 recently recently RB cord-015021-pol2qm74 6624 18 established establish VBN cord-015021-pol2qm74 6624 19 . . . cord-015021-pol2qm74 6625 1 The the DT cord-015021-pol2qm74 6625 2 aim aim NN cord-015021-pol2qm74 6625 3 of of IN cord-015021-pol2qm74 6625 4 our -PRON- PRP$ cord-015021-pol2qm74 6625 5 present present JJ cord-015021-pol2qm74 6625 6 study study NN cord-015021-pol2qm74 6625 7 was be VBD cord-015021-pol2qm74 6625 8 to to TO cord-015021-pol2qm74 6625 9 investigate investigate VB cord-015021-pol2qm74 6625 10 the the DT cord-015021-pol2qm74 6625 11 effect effect NN cord-015021-pol2qm74 6625 12 of of IN cord-015021-pol2qm74 6625 13 parenteral parenteral JJ cord-015021-pol2qm74 6625 14 indomethacin indomethacin NN cord-015021-pol2qm74 6625 15 on on IN cord-015021-pol2qm74 6625 16 the the DT cord-015021-pol2qm74 6625 17 immune immune JJ cord-015021-pol2qm74 6625 18 system system NN cord-015021-pol2qm74 6625 19 of of IN cord-015021-pol2qm74 6625 20 patients patient NNS cord-015021-pol2qm74 6625 21 under under IN cord-015021-pol2qm74 6625 22 major major JJ cord-015021-pol2qm74 6625 23 operations operation NNS cord-015021-pol2qm74 6625 24 . . . cord-015021-pol2qm74 6626 1 Our -PRON- PRP$ cord-015021-pol2qm74 6626 2 study study NN cord-015021-pol2qm74 6626 3 included include VBD cord-015021-pol2qm74 6626 4 20 20 CD cord-015021-pol2qm74 6626 5 operated operate VBN cord-015021-pol2qm74 6626 6 patients patient NNS cord-015021-pol2qm74 6626 7 , , , cord-015021-pol2qm74 6626 8 10 10 CD cord-015021-pol2qm74 6626 9 of of IN cord-015021-pol2qm74 6626 10 which which WDT cord-015021-pol2qm74 6626 11 received receive VBD cord-015021-pol2qm74 6626 12 100 100 CD cord-015021-pol2qm74 6626 13 mg mg NNP cord-015021-pol2qm74 6626 14 indomethacin indomethacin NN cord-015021-pol2qm74 6626 15 before before RB cord-015021-pol2qm74 6626 16 and and CC cord-015021-pol2qm74 6626 17 1,2 1,2 CD cord-015021-pol2qm74 6626 18 and and CC cord-015021-pol2qm74 6626 19 3 3 CD cord-015021-pol2qm74 6626 20 days day NNS cord-015021-pol2qm74 6626 21 after after IN cord-015021-pol2qm74 6626 22 surgery surgery NN cord-015021-pol2qm74 6626 23 ( ( -LRB- cord-015021-pol2qm74 6626 24 group group NN cord-015021-pol2qm74 6626 25 A A NNP cord-015021-pol2qm74 6626 26 ) ) -RRB- cord-015021-pol2qm74 6626 27 and and CC cord-015021-pol2qm74 6626 28 10 10 CD cord-015021-pol2qm74 6626 29 patients patient NNS cord-015021-pol2qm74 6626 30 received receive VBD cord-015021-pol2qm74 6626 31 no no DT cord-015021-pol2qm74 6626 32 antiinflammatory antiinflammatory JJ cord-015021-pol2qm74 6626 33 therapy therapy NN cord-015021-pol2qm74 6626 34 ( ( -LRB- cord-015021-pol2qm74 6626 35 group group NN cord-015021-pol2qm74 6626 36 B B NNP cord-015021-pol2qm74 6626 37 ) ) -RRB- cord-015021-pol2qm74 6626 38 . . . cord-015021-pol2qm74 6627 1 We -PRON- PRP cord-015021-pol2qm74 6627 2 measured measure VBD cord-015021-pol2qm74 6627 3 total total JJ cord-015021-pol2qm74 6627 4 T T NNP cord-015021-pol2qm74 6627 5 - - HYPH cord-015021-pol2qm74 6627 6 cells cell NNS cord-015021-pol2qm74 6627 7 helper helper NN cord-015021-pol2qm74 6627 8 ( ( -LRB- cord-015021-pol2qm74 6627 9 CD4 CD4 NNP cord-015021-pol2qm74 6627 10 ) ) -RRB- cord-015021-pol2qm74 6627 11 , , , cord-015021-pol2qm74 6627 12 suppressor suppressor NN cord-015021-pol2qm74 6627 13 ( ( -LRB- cord-015021-pol2qm74 6627 14 CD8 CD8 NNP cord-015021-pol2qm74 6627 15 ) ) -RRB- cord-015021-pol2qm74 6627 16 , , , cord-015021-pol2qm74 6627 17 NK NK NNP cord-015021-pol2qm74 6627 18 - - HYPH cord-015021-pol2qm74 6627 19 cells cell NNS cord-015021-pol2qm74 6627 20 and and CC cord-015021-pol2qm74 6627 21 interleukin-1 interleukin-1 NN cord-015021-pol2qm74 6627 22 and and CC cord-015021-pol2qm74 6627 23 TNF TNF NNP cord-015021-pol2qm74 6627 24 production production NN cord-015021-pol2qm74 6627 25 by by IN cord-015021-pol2qm74 6627 26 PHA PHA NNP cord-015021-pol2qm74 6627 27 or or CC cord-015021-pol2qm74 6627 28 endodoxin endodoxin NNP cord-015021-pol2qm74 6627 29 ( ( -LRB- cord-015021-pol2qm74 6627 30 LPS LPS NNP cord-015021-pol2qm74 6627 31 ) ) -RRB- cord-015021-pol2qm74 6627 32 stimulated stimulate VBD cord-015021-pol2qm74 6627 33 peripheral peripheral JJ cord-015021-pol2qm74 6627 34 blood blood NN cord-015021-pol2qm74 6627 35 mononuclear mononuclear NN cord-015021-pol2qm74 6627 36 cells cell NNS cord-015021-pol2qm74 6627 37 at at IN cord-015021-pol2qm74 6627 38 day day NN cord-015021-pol2qm74 6627 39 0 0 CD cord-015021-pol2qm74 6627 40 and and CC cord-015021-pol2qm74 6627 41 1 1 CD cord-015021-pol2qm74 6627 42 , , , cord-015021-pol2qm74 6627 43 3 3 CD cord-015021-pol2qm74 6627 44 and and CC cord-015021-pol2qm74 6627 45 7 7 CD cord-015021-pol2qm74 6627 46 days day NNS cord-015021-pol2qm74 6627 47 after after IN cord-015021-pol2qm74 6627 48 operation operation NN cord-015021-pol2qm74 6627 49 . . . cord-015021-pol2qm74 6628 1 In in IN cord-015021-pol2qm74 6628 2 group group NN cord-015021-pol2qm74 6628 3 A A NNP cord-015021-pol2qm74 6628 4 we -PRON- PRP cord-015021-pol2qm74 6628 5 detected detect VBD cord-015021-pol2qm74 6628 6 a a DT cord-015021-pol2qm74 6628 7 significant significant JJ cord-015021-pol2qm74 6628 8 ( ( -LRB- cord-015021-pol2qm74 6628 9 p<0.05 p<0.05 CD cord-015021-pol2qm74 6628 10 ) ) -RRB- cord-015021-pol2qm74 6628 11 increase increase NN cord-015021-pol2qm74 6628 12 in in IN cord-015021-pol2qm74 6628 13 CD4 CD4 NNP cord-015021-pol2qm74 6628 14 / / SYM cord-015021-pol2qm74 6628 15 CD8 CD8 NNP cord-015021-pol2qm74 6628 16 ratio ratio NN cord-015021-pol2qm74 6628 17 on on IN cord-015021-pol2qm74 6628 18 day day NN cord-015021-pol2qm74 6628 19 3 3 CD cord-015021-pol2qm74 6628 20 while while IN cord-015021-pol2qm74 6628 21 no no DT cord-015021-pol2qm74 6628 22 differences difference NNS cord-015021-pol2qm74 6628 23 were be VBD cord-015021-pol2qm74 6628 24 ~oted ~ote VBN cord-015021-pol2qm74 6628 25 in in IN cord-015021-pol2qm74 6628 26 NK NK NNP cord-015021-pol2qm74 6628 27 - - HYPH cord-015021-pol2qm74 6628 28 cells cell NNS cord-015021-pol2qm74 6628 29 or or CC cord-015021-pol2qm74 6628 30 cytokine cytokine NN cord-015021-pol2qm74 6628 31 production production NN cord-015021-pol2qm74 6628 32 in in IN cord-015021-pol2qm74 6628 33 both both DT cord-015021-pol2qm74 6628 34 groups group NNS cord-015021-pol2qm74 6628 35 ( ( -LRB- cord-015021-pol2qm74 6628 36 Table table NN cord-015021-pol2qm74 6628 37 1 1 CD cord-015021-pol2qm74 6628 38 ) ) -RRB- cord-015021-pol2qm74 6628 39 . . . cord-015021-pol2qm74 6629 1 It -PRON- PRP cord-015021-pol2qm74 6629 2 seems seem VBZ cord-015021-pol2qm74 6629 3 , , , cord-015021-pol2qm74 6629 4 therefore therefore RB cord-015021-pol2qm74 6629 5 , , , cord-015021-pol2qm74 6629 6 that that IN cord-015021-pol2qm74 6629 7 parenterai parenterai FW cord-015021-pol2qm74 6629 8 indomethacin indomethacin NNP cord-015021-pol2qm74 6629 9 may may MD cord-015021-pol2qm74 6629 10 have have VB cord-015021-pol2qm74 6629 11 a a DT cord-015021-pol2qm74 6629 12 benefitial benefitial JJ cord-015021-pol2qm74 6629 13 effect effect NN cord-015021-pol2qm74 6629 14 on on IN cord-015021-pol2qm74 6629 15 the the DT cord-015021-pol2qm74 6629 16 immune immune JJ cord-015021-pol2qm74 6629 17 system system NN cord-015021-pol2qm74 6629 18 of of IN cord-015021-pol2qm74 6629 19 patients patient NNS cord-015021-pol2qm74 6629 20 under under IN cord-015021-pol2qm74 6629 21 major major JJ cord-015021-pol2qm74 6629 22 operations operation NNS cord-015021-pol2qm74 6629 23 by by IN cord-015021-pol2qm74 6629 24 increasing increase VBG cord-015021-pol2qm74 6629 25 the the DT cord-015021-pol2qm74 6629 26 T t NN cord-015021-pol2qm74 6629 27 - - HYPH cord-015021-pol2qm74 6629 28 helper helper NN cord-015021-pol2qm74 6629 29 /T /T . cord-015021-pol2qm74 6629 30 - - HYPH cord-015021-pol2qm74 6629 31 suppressor suppressor NN cord-015021-pol2qm74 6629 32 cell cell NN cord-015021-pol2qm74 6629 33 ratio ratio NN cord-015021-pol2qm74 6629 34 while while IN cord-015021-pol2qm74 6629 35 having have VBG cord-015021-pol2qm74 6629 36 no no DT cord-015021-pol2qm74 6629 37 effect effect NN cord-015021-pol2qm74 6629 38 on on IN cord-015021-pol2qm74 6629 39 the the DT cord-015021-pol2qm74 6629 40 production production NN cord-015021-pol2qm74 6629 41 of of IN cord-015021-pol2qm74 6629 42 cytokines cytokine NNS cord-015021-pol2qm74 6629 43 by by IN cord-015021-pol2qm74 6629 44 peripheral peripheral JJ cord-015021-pol2qm74 6629 45 blood blood NN cord-015021-pol2qm74 6629 46 mononuclear mononuclear NN cord-015021-pol2qm74 6629 47 cells cell NNS cord-015021-pol2qm74 6629 48 . . . cord-015021-pol2qm74 6630 1 This this DT cord-015021-pol2qm74 6630 2 study study NN cord-015021-pol2qm74 6630 3 was be VBD cord-015021-pol2qm74 6630 4 undertaken undertake VBN cord-015021-pol2qm74 6630 5 tD td CD cord-015021-pol2qm74 6630 6 dete dete NNP cord-015021-pol2qm74 6630 7 ~ ~ NFP cord-015021-pol2qm74 6630 8 nnine nnine VB cord-015021-pol2qm74 6630 9 the the DT cord-015021-pol2qm74 6630 10 role role NN cord-015021-pol2qm74 6630 11 of of IN cord-015021-pol2qm74 6630 12 prostaglandin prostaglandin JJ cord-015021-pol2qm74 6630 13 synthesis synthesis NN cord-015021-pol2qm74 6630 14 inhibitor inhibitor NN cord-015021-pol2qm74 6630 15 on on IN cord-015021-pol2qm74 6630 16 survival survival NNP cord-015021-pol2qm74 6630 17 post post NN cord-015021-pol2qm74 6630 18 traulna traulna NNP cord-015021-pol2qm74 6630 19 sepsis sepsis NN cord-015021-pol2qm74 6630 20 . . . cord-015021-pol2qm74 6631 1 Analysis analysis NN cord-015021-pol2qm74 6631 2 of of IN cord-015021-pol2qm74 6631 3 the the DT cord-015021-pol2qm74 6631 4 effects effect NNS cord-015021-pol2qm74 6631 5 of of IN cord-015021-pol2qm74 6631 6 prostaglandin prostaglandin NN cord-015021-pol2qm74 6631 7 synthesis synthesis NN cord-015021-pol2qm74 6631 8 inhibitor inhibitor NN cord-015021-pol2qm74 6631 9 on on IN cord-015021-pol2qm74 6631 10 survival survival NN cord-015021-pol2qm74 6631 11 of of IN cord-015021-pol2qm74 6631 12 four four CD cord-015021-pol2qm74 6631 13 groups group NNS cord-015021-pol2qm74 6631 14 of of IN cord-015021-pol2qm74 6631 15 15 15 CD cord-015021-pol2qm74 6631 16 mice mouse NNS cord-015021-pol2qm74 6631 17 each each DT cord-015021-pol2qm74 6631 18 were be VBD cord-015021-pol2qm74 6631 19 made make VBN cord-015021-pol2qm74 6631 20 after after IN cord-015021-pol2qm74 6631 21 laparatomy laparatomy NN cord-015021-pol2qm74 6631 22 and and CC cord-015021-pol2qm74 6631 23 intravenous intravenous JJ cord-015021-pol2qm74 6631 24 administration administration NN cord-015021-pol2qm74 6631 25 of of IN cord-015021-pol2qm74 6631 26 live live JJ cord-015021-pol2qm74 6631 27 E.coli E.coli NNS cord-015021-pol2qm74 6631 28 . . . cord-015021-pol2qm74 6632 1 Post post JJ cord-015021-pol2qm74 6632 2 trauma trauma NN cord-015021-pol2qm74 6632 3 sepsis sepsis NN cord-015021-pol2qm74 6632 4 , , , cord-015021-pol2qm74 6632 5 Group Group NNP cord-015021-pol2qm74 6632 6 A A NNP cord-015021-pol2qm74 6632 7 received receive VBD cord-015021-pol2qm74 6632 8 no no DT cord-015021-pol2qm74 6632 9 treatment treatment NN cord-015021-pol2qm74 6632 10 ; ; : cord-015021-pol2qm74 6632 11 Group Group NNP cord-015021-pol2qm74 6632 12 B B NNP cord-015021-pol2qm74 6632 13 received receive VBD cord-015021-pol2qm74 6632 14 antibiotics antibiotic NNS cord-015021-pol2qm74 6632 15 IM im JJ cord-015021-pol2qm74 6632 16 ; ; : cord-015021-pol2qm74 6632 17 Group Group NNP cord-015021-pol2qm74 6632 18 C C NNP cord-015021-pol2qm74 6632 19 received receive VBD cord-015021-pol2qm74 6632 20 prostaglandin prostaglandin JJ cord-015021-pol2qm74 6632 21 synthesis synthesis NN cord-015021-pol2qm74 6632 22 inhibitor inhibitor NN cord-015021-pol2qm74 6632 23 IM IM NNP cord-015021-pol2qm74 6632 24 and and CC cord-015021-pol2qm74 6632 25 Group Group NNP cord-015021-pol2qm74 6632 26 D D NNP cord-015021-pol2qm74 6632 27 received receive VBD cord-015021-pol2qm74 6632 28 both both DT cord-015021-pol2qm74 6632 29 antibiotics antibiotic NNS cord-015021-pol2qm74 6632 30 and and CC cord-015021-pol2qm74 6632 31 prostaglandin prostaglandin NN cord-015021-pol2qm74 6632 32 synthesis synthesis NN cord-015021-pol2qm74 6632 33 inhibitor inhibitor NN cord-015021-pol2qm74 6632 34 IM IM NNP cord-015021-pol2qm74 6632 35 . . . cord-015021-pol2qm74 6633 1 Survival survival NN cord-015021-pol2qm74 6633 2 time time NN cord-015021-pol2qm74 6633 3 was be VBD cord-015021-pol2qm74 6633 4 longest long JJS cord-015021-pol2qm74 6633 5 in in IN cord-015021-pol2qm74 6633 6 group group NN cord-015021-pol2qm74 6633 7 treated treat VBN cord-015021-pol2qm74 6633 8 with with IN cord-015021-pol2qm74 6633 9 prostaglandin prostaglandin JJ cord-015021-pol2qm74 6633 10 synthesis synthesis NN cord-015021-pol2qm74 6633 11 inhibitor inhibitor NN cord-015021-pol2qm74 6633 12 and and CC cord-015021-pol2qm74 6633 13 antibiotics antibiotic NNS cord-015021-pol2qm74 6633 14 post post VBP cord-015021-pol2qm74 6633 15 trauma trauma NN cord-015021-pol2qm74 6633 16 sepsis sepsis NN cord-015021-pol2qm74 6633 17 . . . cord-015021-pol2qm74 6634 1 The the DT cord-015021-pol2qm74 6634 2 singular singular JJ cord-015021-pol2qm74 6634 3 use use NN cord-015021-pol2qm74 6634 4 of of IN cord-015021-pol2qm74 6634 5 either either CC cord-015021-pol2qm74 6634 6 antibiotic antibiotic JJ cord-015021-pol2qm74 6634 7 or or CC cord-015021-pol2qm74 6634 8 prostaglandin prostaglandin JJ cord-015021-pol2qm74 6634 9 synthesis synthesis NN cord-015021-pol2qm74 6634 10 inhibitor inhibitor NN cord-015021-pol2qm74 6634 11 did do VBD cord-015021-pol2qm74 6634 12 not not RB cord-015021-pol2qm74 6634 13 alter alter VB cord-015021-pol2qm74 6634 14 the the DT cord-015021-pol2qm74 6634 15 outcome outcome NN cord-015021-pol2qm74 6634 16 on on IN cord-015021-pol2qm74 6634 17 survival survival NN cord-015021-pol2qm74 6634 18 . . . cord-015021-pol2qm74 6635 1 Mortality mortality NN cord-015021-pol2qm74 6635 2 rate rate NN cord-015021-pol2qm74 6635 3 was be VBD cord-015021-pol2qm74 6635 4 lowest low JJS cord-015021-pol2qm74 6635 5 in in IN cord-015021-pol2qm74 6635 6 the the DT cord-015021-pol2qm74 6635 7 group group NN cord-015021-pol2qm74 6635 8 treated treat VBN cord-015021-pol2qm74 6635 9 with with IN cord-015021-pol2qm74 6635 10 combined combined JJ cord-015021-pol2qm74 6635 11 prostaglandin prostaglandin NN cord-015021-pol2qm74 6635 12 synthesis synthesis NN cord-015021-pol2qm74 6635 13 inhibitor inhibitor NN cord-015021-pol2qm74 6635 14 and and CC cord-015021-pol2qm74 6635 15 antibiotics antibiotic NNS cord-015021-pol2qm74 6635 16 . . . cord-015021-pol2qm74 6636 1 Use use NN cord-015021-pol2qm74 6636 2 of of IN cord-015021-pol2qm74 6636 3 this this DT cord-015021-pol2qm74 6636 4 combination combination NN cord-015021-pol2qm74 6636 5 showed show VBD cord-015021-pol2qm74 6636 6 a a DT cord-015021-pol2qm74 6636 7 reduction reduction NN cord-015021-pol2qm74 6636 8 in in IN cord-015021-pol2qm74 6636 9 bacterial bacterial JJ cord-015021-pol2qm74 6636 10 growth growth NN cord-015021-pol2qm74 6636 11 in in IN cord-015021-pol2qm74 6636 12 peritoneal peritoneal NN cord-015021-pol2qm74 6636 13 and and CC cord-015021-pol2qm74 6636 14 blood blood NN cord-015021-pol2qm74 6636 15 samples sample NNS cord-015021-pol2qm74 6636 16 , , , cord-015021-pol2qm74 6636 17 mild mild JJ cord-015021-pol2qm74 6636 18 morphologic morphologic JJ cord-015021-pol2qm74 6636 19 changes change NNS cord-015021-pol2qm74 6636 20 secondary secondary JJ cord-015021-pol2qm74 6636 21 to to IN cord-015021-pol2qm74 6636 22 sepsis sepsis NN cord-015021-pol2qm74 6636 23 in in IN cord-015021-pol2qm74 6636 24 the the DT cord-015021-pol2qm74 6636 25 heart heart NN cord-015021-pol2qm74 6636 26 , , , cord-015021-pol2qm74 6636 27 lungs lung NNS cord-015021-pol2qm74 6636 28 , , , cord-015021-pol2qm74 6636 29 liver liver NN cord-015021-pol2qm74 6636 30 , , , cord-015021-pol2qm74 6636 31 kidney kidney NN cord-015021-pol2qm74 6636 32 and and CC cord-015021-pol2qm74 6636 33 stomach stomach NN cord-015021-pol2qm74 6636 34 and and CC cord-015021-pol2qm74 6636 35 marked marked JJ cord-015021-pol2qm74 6636 36 enhancement enhancement NN cord-015021-pol2qm74 6636 37 of of IN cord-015021-pol2qm74 6636 38 mean mean JJ cord-015021-pol2qm74 6636 39 level level NN cord-015021-pol2qm74 6636 40 of of IN cord-015021-pol2qm74 6636 41 activity activity NN cord-015021-pol2qm74 6636 42 . . . cord-015021-pol2qm74 6637 1 The the DT cord-015021-pol2qm74 6637 2 study study NN cord-015021-pol2qm74 6637 3 indicates indicate VBZ cord-015021-pol2qm74 6637 4 that that IN cord-015021-pol2qm74 6637 5 addition addition NN cord-015021-pol2qm74 6637 6 of of IN cord-015021-pol2qm74 6637 7 prostaglandin prostaglandin JJ cord-015021-pol2qm74 6637 8 synthesis synthesis NN cord-015021-pol2qm74 6637 9 inhibitor inhibitor NN cord-015021-pol2qm74 6637 10 in in IN cord-015021-pol2qm74 6637 11 treatment treatment NN cord-015021-pol2qm74 6637 12 of of IN cord-015021-pol2qm74 6637 13 trauma trauma NN cord-015021-pol2qm74 6637 14 - - HYPH cord-015021-pol2qm74 6637 15 sepsis sepsis NN cord-015021-pol2qm74 6637 16 has have VBZ cord-015021-pol2qm74 6637 17 clear clear JJ cord-015021-pol2qm74 6637 18 beneficial beneficial JJ cord-015021-pol2qm74 6637 19 effects effect NNS cord-015021-pol2qm74 6637 20 . . . cord-015021-pol2qm74 6638 1 Interferon- Interferon- NNP cord-015021-pol2qm74 6638 2 ? ? . cord-015021-pol2qm74 6639 1 ( ( -LRB- cord-015021-pol2qm74 6639 2 IFN IFN NNP cord-015021-pol2qm74 6639 3 - - HYPH cord-015021-pol2qm74 6639 4 y y NNP cord-015021-pol2qm74 6639 5 ) ) -RRB- cord-015021-pol2qm74 6639 6 is be VBZ cord-015021-pol2qm74 6639 7 a a DT cord-015021-pol2qm74 6639 8 potent potent JJ cord-015021-pol2qm74 6639 9 immunostimulant immunostimulant NN cord-015021-pol2qm74 6639 10 which which WDT cord-015021-pol2qm74 6639 11 has have VBZ cord-015021-pol2qm74 6639 12 been be VBN cord-015021-pol2qm74 6639 13 shown show VBN cord-015021-pol2qm74 6639 14 to to TO cord-015021-pol2qm74 6639 15 be be VB cord-015021-pol2qm74 6639 16 detrimental detrimental JJ cord-015021-pol2qm74 6639 17 when when WRB cord-015021-pol2qm74 6639 18 administered administer VBN cord-015021-pol2qm74 6639 19 during during IN cord-015021-pol2qm74 6639 20 septic septic JJ cord-015021-pol2qm74 6639 21 shock shock NN cord-015021-pol2qm74 6639 22 . . . cord-015021-pol2qm74 6640 1 Blockade blockade NN cord-015021-pol2qm74 6640 2 of of IN cord-015021-pol2qm74 6640 3 this this DT cord-015021-pol2qm74 6640 4 cytokine cytokine NN cord-015021-pol2qm74 6640 5 however however RB cord-015021-pol2qm74 6640 6 is be VBZ cord-015021-pol2qm74 6640 7 beneficial beneficial JJ cord-015021-pol2qm74 6640 8 during during IN cord-015021-pol2qm74 6640 9 the the DT cord-015021-pol2qm74 6640 10 acute acute JJ cord-015021-pol2qm74 6640 11 septic septic JJ cord-015021-pol2qm74 6640 12 response response NN cord-015021-pol2qm74 6640 13 . . . cord-015021-pol2qm74 6641 1 The the DT cord-015021-pol2qm74 6641 2 aim aim NN cord-015021-pol2qm74 6641 3 of of IN cord-015021-pol2qm74 6641 4 this this DT cord-015021-pol2qm74 6641 5 study study NN cord-015021-pol2qm74 6641 6 was be VBD cord-015021-pol2qm74 6641 7 to to TO cord-015021-pol2qm74 6641 8 evaluate evaluate VB cord-015021-pol2qm74 6641 9 the the DT cord-015021-pol2qm74 6641 10 cellular cellular JJ cord-015021-pol2qm74 6641 11 effects effect NNS cord-015021-pol2qm74 6641 12 of of IN cord-015021-pol2qm74 6641 13 this this DT cord-015021-pol2qm74 6641 14 cytokine cytokine NN cord-015021-pol2qm74 6641 15 and and CC cord-015021-pol2qm74 6641 16 its -PRON- PRP$ cord-015021-pol2qm74 6641 17 blocking block VBG cord-015021-pol2qm74 6641 18 monoclonal monoclonal JJ cord-015021-pol2qm74 6641 19 antibody antibody NN cord-015021-pol2qm74 6641 20 ( ( -LRB- cord-015021-pol2qm74 6641 21 MoAb MoAb NNP cord-015021-pol2qm74 6641 22 ) ) -RRB- cord-015021-pol2qm74 6641 23 in in IN cord-015021-pol2qm74 6641 24 lethal lethal JJ cord-015021-pol2qm74 6641 25 sepsis sepsis NN cord-015021-pol2qm74 6641 26 following follow VBG cord-015021-pol2qm74 6641 27 injury injury NN cord-015021-pol2qm74 6641 28 . . . cord-015021-pol2qm74 6642 1 100 100 CD cord-015021-pol2qm74 6642 2 female female JJ cord-015021-pol2qm74 6642 3 CD-1 CD-1 NNP cord-015021-pol2qm74 6642 4 mice mouse NNS cord-015021-pol2qm74 6642 5 were be VBD cord-015021-pol2qm74 6642 6 randomized randomize VBN cord-015021-pol2qm74 6642 7 into into IN cord-015021-pol2qm74 6642 8 two two CD cord-015021-pol2qm74 6642 9 groups group NNS cord-015021-pol2qm74 6642 10 : : : cord-015021-pol2qm74 6642 11 Septic septic NN cord-015021-pol2qm74 6642 12 = = SYM cord-015021-pol2qm74 6642 13 LPS LPS NNP cord-015021-pol2qm74 6642 14 vs vs IN cord-015021-pol2qm74 6642 15 injury injury NN cord-015021-pol2qm74 6642 16 = = SYM cord-015021-pol2qm74 6642 17 hind hind NN cord-015021-pol2qm74 6642 18 limb limb NN cord-015021-pol2qm74 6642 19 amputation amputation NN cord-015021-pol2qm74 6643 1 ( ( -LRB- cord-015021-pol2qm74 6643 2 HLA HLA NNP cord-015021-pol2qm74 6643 3 vs vs IN cord-015021-pol2qm74 6643 4 IgG. IgG. NNP cord-015021-pol2qm74 6644 1 nStats= nStats= NNP cord-015021-pol2qm74 6644 2 ANOVA= ANOVA= NNP cord-015021-pol2qm74 6645 1 p<0.05 p<0.05 CD cord-015021-pol2qm74 6646 1 vs vs IN cord-015021-pol2qm74 6646 2 lgG lgG NNP cord-015021-pol2qm74 6646 3 IFN IFN NNP cord-015021-pol2qm74 6646 4 - - HYPH cord-015021-pol2qm74 6646 5 y y NNP cord-015021-pol2qm74 6646 6 was be VBD cord-015021-pol2qm74 6646 7 detrimental detrimental JJ cord-015021-pol2qm74 6646 8 when when WRB cord-015021-pol2qm74 6646 9 given give VBN cord-015021-pol2qm74 6646 10 to to TO cord-015021-pol2qm74 6646 11 control control VB cord-015021-pol2qm74 6646 12 septic septic JJ cord-015021-pol2qm74 6646 13 animals animal NNS cord-015021-pol2qm74 6646 14 . . . cord-015021-pol2qm74 6647 1 However however RB cord-015021-pol2qm74 6647 2 its -PRON- PRP$ cord-015021-pol2qm74 6647 3 blocking block VBG cord-015021-pol2qm74 6647 4 MoAb MoAb NNP cord-015021-pol2qm74 6647 5 was be VBD cord-015021-pol2qm74 6647 6 protective protective JJ cord-015021-pol2qm74 6647 7 ( ( -LRB- cord-015021-pol2qm74 6647 8 p<0.05 p<0.05 CD cord-015021-pol2qm74 6647 9 ) ) -RRB- cord-015021-pol2qm74 6647 10 . . . cord-015021-pol2qm74 6648 1 Conversely conversely RB cord-015021-pol2qm74 6648 2 IFN IFN NNP cord-015021-pol2qm74 6648 3 - - HYPH cord-015021-pol2qm74 6648 4 y y NNP cord-015021-pol2qm74 6648 5 was be VBD cord-015021-pol2qm74 6648 6 proteetive proteetive JJ cord-015021-pol2qm74 6648 7 in in IN cord-015021-pol2qm74 6648 8 injured injure VBN cord-015021-pol2qm74 6648 9 septic septic JJ cord-015021-pol2qm74 6648 10 animals animal NNS cord-015021-pol2qm74 6648 11 compared compare VBN cord-015021-pol2qm74 6648 12 with with IN cord-015021-pol2qm74 6649 1 anti anti JJ cord-015021-pol2qm74 6649 2 - - JJ cord-015021-pol2qm74 6649 3 IFN- ifn- JJ cord-015021-pol2qm74 6649 4 ? ? . cord-015021-pol2qm74 6649 5 ( ( -LRB- cord-015021-pol2qm74 6649 6 p<0.05 p<0.05 CD cord-015021-pol2qm74 6649 7 ) ) -RRB- cord-015021-pol2qm74 6649 8 . . . cord-015021-pol2qm74 6650 1 These these DT cord-015021-pol2qm74 6650 2 findings finding NNS cord-015021-pol2qm74 6650 3 demonstrate demonstrate VBP cord-015021-pol2qm74 6650 4 that that IN cord-015021-pol2qm74 6650 5 the the DT cord-015021-pol2qm74 6650 6 immune immune JJ cord-015021-pol2qm74 6650 7 stimulant stimulant NN cord-015021-pol2qm74 6650 8 IFN- IFN- NNP cord-015021-pol2qm74 6650 9 ? ? , cord-015021-pol2qm74 6650 10 has have VBZ cord-015021-pol2qm74 6650 11 therapeutic therapeutic JJ cord-015021-pol2qm74 6650 12 potential potential NN cord-015021-pol2qm74 6650 13 in in IN cord-015021-pol2qm74 6650 14 the the DT cord-015021-pol2qm74 6650 15 immunosuppressed immunosuppressed JJ cord-015021-pol2qm74 6650 16 injured injure VBN cord-015021-pol2qm74 6650 17 host host NN cord-015021-pol2qm74 6650 18 predisposed predisposed JJ cord-015021-pol2qm74 6650 19 to to IN cord-015021-pol2qm74 6650 20 sepsis sepsis NN cord-015021-pol2qm74 6650 21 , , , cord-015021-pol2qm74 6650 22 while while IN cord-015021-pol2qm74 6650 23 blockade blockade NN cord-015021-pol2qm74 6650 24 of of IN cord-015021-pol2qm74 6650 25 this this DT cord-015021-pol2qm74 6650 26 cytokine cytokine NN cord-015021-pol2qm74 6650 27 is be VBZ cord-015021-pol2qm74 6650 28 required require VBN cord-015021-pol2qm74 6650 29 for for IN cord-015021-pol2qm74 6650 30 protection protection NN cord-015021-pol2qm74 6650 31 in in IN cord-015021-pol2qm74 6650 32 the the DT cord-015021-pol2qm74 6650 33 septic septic JJ cord-015021-pol2qm74 6650 34 host host NN cord-015021-pol2qm74 6650 35 with with IN cord-015021-pol2qm74 6650 36 a a DT cord-015021-pol2qm74 6650 37 normal normal JJ cord-015021-pol2qm74 6650 38 immune immune JJ cord-015021-pol2qm74 6650 39 response response NN cord-015021-pol2qm74 6650 40 . . . cord-015021-pol2qm74 6651 1 Dept Dept NNP cord-015021-pol2qm74 6651 2 of of IN cord-015021-pol2qm74 6651 3 Surgery Surgery NNP cord-015021-pol2qm74 6651 4 , , , cord-015021-pol2qm74 6651 5 RCSI RCSI NNP cord-015021-pol2qm74 6651 6 , , , cord-015021-pol2qm74 6651 7 Beaumont Beaumont NNP cord-015021-pol2qm74 6651 8 Hospital Hospital NNP cord-015021-pol2qm74 6651 9 , , , cord-015021-pol2qm74 6651 10 Dublin Dublin NNP cord-015021-pol2qm74 6651 11 9 9 CD cord-015021-pol2qm74 6651 12 , , , cord-015021-pol2qm74 6651 13 Ireland Ireland NNP cord-015021-pol2qm74 6651 14 . . . cord-015021-pol2qm74 6652 1 Oxidants oxidant NNS cord-015021-pol2qm74 6652 2 play play VBP cord-015021-pol2qm74 6652 3 a a DT cord-015021-pol2qm74 6652 4 role role NN cord-015021-pol2qm74 6652 5 in in IN cord-015021-pol2qm74 6652 6 physiology physiology NN cord-015021-pol2qm74 6652 7 . . . cord-015021-pol2qm74 6653 1 The the DT cord-015021-pol2qm74 6653 2 potential potential JJ cord-015021-pol2qm74 6653 3 noxious noxious JJ cord-015021-pol2qm74 6653 4 oxidant oxidant JJ cord-015021-pol2qm74 6653 5 biochemistry biochemistry NN cord-015021-pol2qm74 6653 6 is be VBZ cord-015021-pol2qm74 6653 7 restrained restrain VBN cord-015021-pol2qm74 6653 8 by by IN cord-015021-pol2qm74 6653 9 chemically chemically RB cord-015021-pol2qm74 6653 10 distinct distinct JJ cord-015021-pol2qm74 6653 11 antioxidants antioxidant NNS cord-015021-pol2qm74 6653 12 . . . cord-015021-pol2qm74 6654 1 These these DT cord-015021-pol2qm74 6654 2 antioxidants antioxidant NNS cord-015021-pol2qm74 6654 3 , , , cord-015021-pol2qm74 6654 4 which which WDT cord-015021-pol2qm74 6654 5 may may MD cord-015021-pol2qm74 6654 6 reside reside VB cord-015021-pol2qm74 6654 7 in in IN cord-015021-pol2qm74 6654 8 different different JJ cord-015021-pol2qm74 6654 9 cellular cellular JJ cord-015021-pol2qm74 6654 10 compartments compartment NNS cord-015021-pol2qm74 6654 11 , , , cord-015021-pol2qm74 6654 12 can can MD cord-015021-pol2qm74 6654 13 act act VB cord-015021-pol2qm74 6654 14 synergistically synergistically RB cord-015021-pol2qm74 6654 15 . . . cord-015021-pol2qm74 6655 1 In in IN cord-015021-pol2qm74 6655 2 normal normal JJ cord-015021-pol2qm74 6655 3 physiology physiology NN cord-015021-pol2qm74 6655 4 an an DT cord-015021-pol2qm74 6655 5 oxidant oxidant JJ cord-015021-pol2qm74 6655 6 / / SYM cord-015021-pol2qm74 6655 7 antioxidant antioxidant NN cord-015021-pol2qm74 6655 8 bai&nce bai&nce NN cord-015021-pol2qm74 6655 9 exists exist VBZ cord-015021-pol2qm74 6655 10 . . . cord-015021-pol2qm74 6656 1 Unbalance unbalance NN cord-015021-pol2qm74 6656 2 in in IN cord-015021-pol2qm74 6656 3 favour favour NN cord-015021-pol2qm74 6656 4 of of IN cord-015021-pol2qm74 6656 5 the the DT cord-015021-pol2qm74 6656 6 oxidants oxidant NNS cord-015021-pol2qm74 6656 7 is be VBZ cord-015021-pol2qm74 6656 8 called call VBN cord-015021-pol2qm74 6656 9 oxidative oxidative JJ cord-015021-pol2qm74 6656 10 stress stress NN cord-015021-pol2qm74 6656 11 . . . cord-015021-pol2qm74 6657 1 Oxidative oxidative JJ cord-015021-pol2qm74 6657 2 stress stress NN cord-015021-pol2qm74 6657 3 has have VBZ cord-015021-pol2qm74 6657 4 been be VBN cord-015021-pol2qm74 6657 5 implicated implicate VBN cord-015021-pol2qm74 6657 6 in in IN cord-015021-pol2qm74 6657 7 many many JJ cord-015021-pol2qm74 6657 8 pathologies pathology NNS cord-015021-pol2qm74 6657 9 including include VBG cord-015021-pol2qm74 6657 10 lung lung NN cord-015021-pol2qm74 6657 11 diseases(e.g diseases(e.g NNP cord-015021-pol2qm74 6657 12 , , , cord-015021-pol2qm74 6657 13 doxorubicin doxorubicin JJ cord-015021-pol2qm74 6657 14 induced induce VBN cord-015021-pol2qm74 6657 15 cardiotoxicity cardiotoxicity NN cord-015021-pol2qm74 6657 16 ) ) -RRB- cord-015021-pol2qm74 6657 17 , , , cord-015021-pol2qm74 6657 18 ischemia ischemia NN cord-015021-pol2qm74 6657 19 / / SYM cord-015021-pol2qm74 6657 20 reperfnsion reperfnsion NN cord-015021-pol2qm74 6657 21 damage damage NN cord-015021-pol2qm74 6657 22 and and CC cord-015021-pol2qm74 6657 23 central central JJ cord-015021-pol2qm74 6657 24 nervous nervous JJ cord-015021-pol2qm74 6657 25 system system NN cord-015021-pol2qm74 6657 26 trauma trauma NN cord-015021-pol2qm74 6657 27 . . . cord-015021-pol2qm74 6658 1 Transition transition NN cord-015021-pol2qm74 6658 2 metals metal NNS cord-015021-pol2qm74 6658 3 such such JJ cord-015021-pol2qm74 6658 4 as as IN cord-015021-pol2qm74 6658 5 iron iron NN cord-015021-pol2qm74 6658 6 are be VBP cord-015021-pol2qm74 6658 7 involved involve VBN cord-015021-pol2qm74 6658 8 in in IN cord-015021-pol2qm74 6658 9 the the DT cord-015021-pol2qm74 6658 10 early early JJ cord-015021-pol2qm74 6658 11 events event NNS cord-015021-pol2qm74 6658 12 leading lead VBG cord-015021-pol2qm74 6658 13 to to IN cord-015021-pol2qm74 6658 14 oxidative oxidative JJ cord-015021-pol2qm74 6658 15 damage damage NN cord-015021-pol2qm74 6658 16 in in IN cord-015021-pol2qm74 6658 17 these these DT cord-015021-pol2qm74 6658 18 pathologies pathology NNS cord-015021-pol2qm74 6658 19 . . . cord-015021-pol2qm74 6659 1 This this DT cord-015021-pol2qm74 6659 2 has have VBZ cord-015021-pol2qm74 6659 3 been be VBN cord-015021-pol2qm74 6659 4 underlined underline VBN cord-015021-pol2qm74 6659 5 by by IN cord-015021-pol2qm74 6659 6 the the DT cord-015021-pol2qm74 6659 7 finding finding NN cord-015021-pol2qm74 6659 8 that that IN cord-015021-pol2qm74 6659 9 postischemic postischemic JJ cord-015021-pol2qm74 6659 10 CNS cns NN cord-015021-pol2qm74 6659 11 pathology pathology NN cord-015021-pol2qm74 6659 12 closely closely RB cord-015021-pol2qm74 6659 13 resembles resemble VBZ cord-015021-pol2qm74 6659 14 that that IN cord-015021-pol2qm74 6659 15 caused cause VBN cord-015021-pol2qm74 6659 16 by by IN cord-015021-pol2qm74 6659 17 a a DT cord-015021-pol2qm74 6659 18 chemical chemical JJ cord-015021-pol2qm74 6659 19 oxidative oxidative JJ cord-015021-pol2qm74 6659 20 insult insult NN cord-015021-pol2qm74 6659 21 ( ( -LRB- cord-015021-pol2qm74 6659 22 e.g. e.g. IN cord-015021-pol2qm74 6659 23 iron iron NN cord-015021-pol2qm74 6659 24 microinjection microinjection NN cord-015021-pol2qm74 6659 25 ) ) -RRB- cord-015021-pol2qm74 6659 26 . . . cord-015021-pol2qm74 6660 1 Moreover moreover RB cord-015021-pol2qm74 6660 2 , , , cord-015021-pol2qm74 6660 3 a a DT cord-015021-pol2qm74 6660 4 protective protective JJ cord-015021-pol2qm74 6660 5 effect effect NN cord-015021-pol2qm74 6660 6 of of IN cord-015021-pol2qm74 6660 7 oxygen oxygen NN cord-015021-pol2qm74 6660 8 - - HYPH cord-015021-pol2qm74 6660 9 radical radical JJ cord-015021-pol2qm74 6660 10 scavening scavene VBG cord-015021-pol2qm74 6660 11 agents agent NNS cord-015021-pol2qm74 6660 12 or or CC cord-015021-pol2qm74 6660 13 compounds compound NNS cord-015021-pol2qm74 6660 14 that that WDT cord-015021-pol2qm74 6660 15 inhibit inhibit VBP cord-015021-pol2qm74 6660 16 lipid lipid NN cord-015021-pol2qm74 6660 17 peroxidation peroxidation NN cord-015021-pol2qm74 6660 18 ( ( -LRB- cord-015021-pol2qm74 6660 19 antioxidants antioxidant NNS cord-015021-pol2qm74 6660 20 ) ) -RRB- cord-015021-pol2qm74 6660 21 in in IN cord-015021-pol2qm74 6660 22 brain brain NN cord-015021-pol2qm74 6660 23 ischemia ischemia NN cord-015021-pol2qm74 6660 24 / / SYM cord-015021-pol2qm74 6660 25 trauma trauma NN cord-015021-pol2qm74 6660 26 is be VBZ cord-015021-pol2qm74 6660 27 apparent apparent JJ cord-015021-pol2qm74 6660 28 . . . cord-015021-pol2qm74 6661 1 Some some DT cord-015021-pol2qm74 6661 2 known know VBN cord-015021-pol2qm74 6661 3 drugs drug NNS cord-015021-pol2qm74 6661 4 ( ( -LRB- cord-015021-pol2qm74 6661 5 e.g. e.g. IN cord-015021-pol2qm74 6661 6 anti anti JJ cord-015021-pol2qm74 6661 7 - - NNS cord-015021-pol2qm74 6661 8 arrhythmics arrhythmic NNS cord-015021-pol2qm74 6661 9 or or CC cord-015021-pol2qm74 6661 10 histamine histamine NN cord-015021-pol2qm74 6661 11 H2-antagonists h2-antagonist NNS cord-015021-pol2qm74 6661 12 may may MD cord-015021-pol2qm74 6661 13 act act VB cord-015021-pol2qm74 6661 14 as as IN cord-015021-pol2qm74 6661 15 non non JJ cord-015021-pol2qm74 6661 16 - - JJ cord-015021-pol2qm74 6661 17 specific specific JJ cord-015021-pol2qm74 6661 18 antioxidants antioxidant NNS cord-015021-pol2qm74 6661 19 . . . cord-015021-pol2qm74 6662 1 Howe Howe NNP cord-015021-pol2qm74 6662 2 ~ ~ NFP cord-015021-pol2qm74 6662 3 er er UH cord-015021-pol2qm74 6662 4 , , , cord-015021-pol2qm74 6662 5 recently recently RB cord-015021-pol2qm74 6662 6 , , , cord-015021-pol2qm74 6662 7 interesting interesting JJ cord-015021-pol2qm74 6662 8 new new JJ cord-015021-pol2qm74 6662 9 membrancespecific membrancespecific NN cord-015021-pol2qm74 6662 10 antioxidants antioxidant NNS cord-015021-pol2qm74 6662 11 ( ( -LRB- cord-015021-pol2qm74 6662 12 e.g. e.g. RB cord-015021-pol2qm74 6662 13 21-aminosterdids 21-aminosterdids CD cord-015021-pol2qm74 6662 14 ) ) -RRB- cord-015021-pol2qm74 6662 15 have have VBP cord-015021-pol2qm74 6662 16 been be VBN cord-015021-pol2qm74 6662 17 designed design VBN cord-015021-pol2qm74 6662 18 . . . cord-015021-pol2qm74 6663 1 Subt&e subt&e CD cord-015021-pol2qm74 6663 2 effects effect NNS cord-015021-pol2qm74 6663 3 on on IN cord-015021-pol2qm74 6663 4 iron iron NN cord-015021-pol2qm74 6663 5 redox redox NN cord-015021-pol2qm74 6663 6 chemistry chemistry NN cord-015021-pol2qm74 6663 7 contributes contribute VBZ cord-015021-pol2qm74 6663 8 to to IN cord-015021-pol2qm74 6663 9 the the DT cord-015021-pol2qm74 6663 10 potent potent JJ cord-015021-pol2qm74 6663 11 antioxidant antioxidant JJ cord-015021-pol2qm74 6663 12 activity activity NN cord-015021-pol2qm74 6663 13 of of IN cord-015021-pol2qm74 6663 14 these these DT cord-015021-pol2qm74 6663 15 21aminosteroids 21aminosteroids CD cord-015021-pol2qm74 6663 16 . . . cord-015021-pol2qm74 6664 1 Since since IN cord-015021-pol2qm74 6664 2 a a DT cord-015021-pol2qm74 6664 3 few few JJ cord-015021-pol2qm74 6664 4 years year NNS cord-015021-pol2qm74 6664 5 , , , cord-015021-pol2qm74 6664 6 one one CD cord-015021-pol2qm74 6664 7 area area NN cord-015021-pol2qm74 6664 8 that that WDT cord-015021-pol2qm74 6664 9 greeted greet VBD cord-015021-pol2qm74 6664 10 enthusimastlcally enthusimastlcally RB cord-015021-pol2qm74 6664 11 in in IN cord-015021-pol2qm74 6664 12 clinical clinical JJ cord-015021-pol2qm74 6664 13 medicine medicine NN cord-015021-pol2qm74 6664 14 is be VBZ cord-015021-pol2qm74 6664 15 that that DT cord-015021-pol2qm74 6664 16 of of IN cord-015021-pol2qm74 6664 17 reoxygenatlon reoxygenatlon NNP cord-015021-pol2qm74 6664 18 injury injury NN cord-015021-pol2qm74 6664 19 or or CC cord-015021-pol2qm74 6664 20 ischemia ischemia NN cord-015021-pol2qm74 6664 21 - - HYPH cord-015021-pol2qm74 6664 22 repeffusion repeffusion NN cord-015021-pol2qm74 6664 23 , , , cord-015021-pol2qm74 6664 24 a a DT cord-015021-pol2qm74 6664 25 phenomenon phenomenon NN cord-015021-pol2qm74 6664 26 accepted accept VBN cord-015021-pol2qm74 6664 27 to to TO cord-015021-pol2qm74 6664 28 make make VB cord-015021-pol2qm74 6664 29 a a DT cord-015021-pol2qm74 6664 30 majo majo NN cord-015021-pol2qm74 6664 31 : : : cord-015021-pol2qm74 6664 32 " " `` cord-015021-pol2qm74 6664 33 contribution contribution NN cord-015021-pol2qm74 6664 34 to to IN cord-015021-pol2qm74 6664 35 organ organ NN cord-015021-pol2qm74 6664 36 dysfunction dysfunction NN cord-015021-pol2qm74 6664 37 in in IN cord-015021-pol2qm74 6664 38 trauma trauma NN cord-015021-pol2qm74 6664 39 , , , cord-015021-pol2qm74 6664 40 shock shock NN cord-015021-pol2qm74 6664 41 and and CC cord-015021-pol2qm74 6664 42 sepsis sepsis NN cord-015021-pol2qm74 6664 43 through through IN cord-015021-pol2qm74 6664 44 the the DT cord-015021-pol2qm74 6664 45 formation formation NN cord-015021-pol2qm74 6664 46 o o NN cord-015021-pol2qm74 6664 47 ( ( -LRB- cord-015021-pol2qm74 6664 48 oxygenated oxygenated JJ cord-015021-pol2qm74 6664 49 free free JJ cord-015021-pol2qm74 6664 50 radical radical JJ cord-015021-pol2qm74 6664 51 species specie NNS cord-015021-pol2qm74 6664 52 . . . cord-015021-pol2qm74 6665 1 However however RB cord-015021-pol2qm74 6665 2 , , , cord-015021-pol2qm74 6665 3 thei thei PRP$ cord-015021-pol2qm74 6665 4 detection detection NN cord-015021-pol2qm74 6665 5 in in IN cord-015021-pol2qm74 6665 6 vivo vivo NN cord-015021-pol2qm74 6665 7 always always RB cord-015021-pol2qm74 6665 8 remains remain VBZ cord-015021-pol2qm74 6665 9 a a DT cord-015021-pol2qm74 6665 10 difficult difficult JJ cord-015021-pol2qm74 6665 11 challenge challenge NN cord-015021-pol2qm74 6665 12 . . . cord-015021-pol2qm74 6666 1 Efforts effort NNS cord-015021-pol2qm74 6666 2 have have VBP cord-015021-pol2qm74 6666 3 been be VBN cord-015021-pol2qm74 6666 4 made make VBN cord-015021-pol2qm74 6666 5 recently recently RB cord-015021-pol2qm74 6666 6 to to TO cord-015021-pol2qm74 6666 7 directly directly RB cord-015021-pol2qm74 6666 8 establish establish VB cord-015021-pol2qm74 6666 9 the the DT cord-015021-pol2qm74 6666 10 formation formation NN cord-015021-pol2qm74 6666 11 of of IN cord-015021-pol2qm74 6666 12 free free JJ cord-015021-pol2qm74 6666 13 radicals radical NNS cord-015021-pol2qm74 6666 14 in in IN cord-015021-pol2qm74 6666 15 biological biological JJ cord-015021-pol2qm74 6666 16 samples sample NNS cord-015021-pol2qm74 6666 17 as as RB cord-015021-pol2qm74 6666 18 complex complex JJ cord-015021-pol2qm74 6666 19 as as IN cord-015021-pol2qm74 6666 20 blood blood NN cord-015021-pol2qm74 6666 21 , , , cord-015021-pol2qm74 6666 22 plasma plasma NN cord-015021-pol2qm74 6666 23 or or CC cord-015021-pol2qm74 6666 24 tissue tissue NN cord-015021-pol2qm74 6666 25 with with IN cord-015021-pol2qm74 6666 26 the the DT cord-015021-pol2qm74 6666 27 use use NN cord-015021-pol2qm74 6666 28 of of IN cord-015021-pol2qm74 6666 29 electron electron NN cord-015021-pol2qm74 6666 30 spin spin NN cord-015021-pol2qm74 6666 31 resonance resonance NN cord-015021-pol2qm74 6666 32 ( ( -LRB- cord-015021-pol2qm74 6666 33 esr esr NNP cord-015021-pol2qm74 6666 34 ) ) -RRB- cord-015021-pol2qm74 6666 35 spectroscopy spectroscopy NNP cord-015021-pol2qm74 6666 36 . . . cord-015021-pol2qm74 6667 1 Using use VBG cord-015021-pol2qm74 6667 2 spin spin NN cord-015021-pol2qm74 6667 3 trapping trap VBG cord-015021-pol2qm74 6667 4 agents agent NNS cord-015021-pol2qm74 6667 5 , , , cord-015021-pol2qm74 6667 6 the the DT cord-015021-pol2qm74 6667 7 presence presence NN cord-015021-pol2qm74 6667 8 of of IN cord-015021-pol2qm74 6667 9 reactive reactive JJ cord-015021-pol2qm74 6667 10 carbon carbon NN cord-015021-pol2qm74 6667 11 - - HYPH cord-015021-pol2qm74 6667 12 and and CC cord-015021-pol2qm74 6667 13 oxygen oxygen NN cord-015021-pol2qm74 6667 14 - - HYPH cord-015021-pol2qm74 6667 15 centered center VBN cord-015021-pol2qm74 6667 16 radicals radical NNS cord-015021-pol2qm74 6667 17 has have VBZ cord-015021-pol2qm74 6667 18 been be VBN cord-015021-pol2qm74 6667 19 demonstrated demonstrate VBN cord-015021-pol2qm74 6667 20 in in IN cord-015021-pol2qm74 6667 21 animals animal NNS cord-015021-pol2qm74 6667 22 blood blood NN cord-015021-pol2qm74 6667 23 submitted submit VBN cord-015021-pol2qm74 6667 24 to to IN cord-015021-pol2qm74 6667 25 heart heart NN cord-015021-pol2qm74 6667 26 , , , cord-015021-pol2qm74 6667 27 renal renal JJ cord-015021-pol2qm74 6667 28 and and CC cord-015021-pol2qm74 6667 29 intestinal intestinal JJ cord-015021-pol2qm74 6667 30 ischemia ischemia NN cord-015021-pol2qm74 6667 31 - - HYPH cord-015021-pol2qm74 6667 32 repeffusion repeffusion NN cord-015021-pol2qm74 6667 33 or or CC cord-015021-pol2qm74 6667 34 to to IN cord-015021-pol2qm74 6667 35 liver liver NN cord-015021-pol2qm74 6667 36 transplantation transplantation NN cord-015021-pol2qm74 6667 37 . . . cord-015021-pol2qm74 6668 1 Recently recently RB cord-015021-pol2qm74 6668 2 , , , cord-015021-pol2qm74 6668 3 the the DT cord-015021-pol2qm74 6668 4 in in IN cord-015021-pol2qm74 6668 5 vivo vivo NN cord-015021-pol2qm74 6668 6 formation formation NN cord-015021-pol2qm74 6668 7 of of IN cord-015021-pol2qm74 6668 8 free free JJ cord-015021-pol2qm74 6668 9 radicals radical NNS cord-015021-pol2qm74 6668 10 in in IN cord-015021-pol2qm74 6668 11 the the DT cord-015021-pol2qm74 6668 12 cerebra cerebra NN cord-015021-pol2qm74 6668 13 ; ; : cord-015021-pol2qm74 6668 14 extracellnlar extracellnlar JJ cord-015021-pol2qm74 6668 15 fluid fluid NN cord-015021-pol2qm74 6668 16 during during IN cord-015021-pol2qm74 6668 17 cerebral cerebral JJ cord-015021-pol2qm74 6668 18 isehemia isehemia NN cord-015021-pol2qm74 6668 19 - - HYPH cord-015021-pol2qm74 6668 20 repeffusion repeffusion NNP cord-015021-pol2qm74 6668 21 has have VBZ cord-015021-pol2qm74 6668 22 been be VBN cord-015021-pol2qm74 6668 23 assessed assess VBN cord-015021-pol2qm74 6668 24 by by IN cord-015021-pol2qm74 6668 25 the the DT cord-015021-pol2qm74 6668 26 spin spin NN cord-015021-pol2qm74 6668 27 trapping trapping NN cord-015021-pol2qm74 6668 28 technique technique NN cord-015021-pol2qm74 6668 29 coupled couple VBN cord-015021-pol2qm74 6668 30 to to IN cord-015021-pol2qm74 6668 31 brain brain NN cord-015021-pol2qm74 6668 32 microdialysis microdialysis NN cord-015021-pol2qm74 6668 33 . . . cord-015021-pol2qm74 6669 1 Esr Esr NNS cord-015021-pol2qm74 6669 2 investigations investigation NNS cord-015021-pol2qm74 6669 3 have have VBP cord-015021-pol2qm74 6669 4 also also RB cord-015021-pol2qm74 6669 5 been be VBN cord-015021-pol2qm74 6669 6 conducted conduct VBN cord-015021-pol2qm74 6669 7 to to TO cord-015021-pol2qm74 6669 8 detect detect VB cord-015021-pol2qm74 6669 9 endotoxin endotoxin NN cord-015021-pol2qm74 6669 10 - - HYPH cord-015021-pol2qm74 6669 11 induced induce VBN cord-015021-pol2qm74 6669 12 free free JJ cord-015021-pol2qm74 6669 13 radical radical JJ cord-015021-pol2qm74 6669 14 generation generation NN cord-015021-pol2qm74 6669 15 in in IN cord-015021-pol2qm74 6669 16 rat rat NN cord-015021-pol2qm74 6669 17 or or CC cord-015021-pol2qm74 6669 18 baboon baboon NN cord-015021-pol2qm74 6669 19 liver liver NN cord-015021-pol2qm74 6669 20 and and CC cord-015021-pol2qm74 6669 21 _SP cord-015021-pol2qm74 6669 22 Oxygen oxygen NN cord-015021-pol2qm74 6669 23 free free JJ cord-015021-pol2qm74 6669 24 radicals radical NNS cord-015021-pol2qm74 6669 25 ( ( -LRB- cord-015021-pol2qm74 6669 26 OFR OFR NNP cord-015021-pol2qm74 6669 27 ) ) -RRB- cord-015021-pol2qm74 6669 28 , , , cord-015021-pol2qm74 6669 29 produced produce VBD cord-015021-pol2qm74 6669 30 both both CC cord-015021-pol2qm74 6669 31 at at IN cord-015021-pol2qm74 6669 32 intra intra JJ cord-015021-pol2qm74 6669 33 - - JJ cord-015021-pol2qm74 6669 34 and and CC cord-015021-pol2qm74 6669 35 extra extra JJ cord-015021-pol2qm74 6669 36 - - JJ cord-015021-pol2qm74 6669 37 cellular cellular JJ cord-015021-pol2qm74 6669 38 levels level NNS cord-015021-pol2qm74 6669 39 , , , cord-015021-pol2qm74 6669 40 seem seem VBP cord-015021-pol2qm74 6669 41 to to TO cord-015021-pol2qm74 6669 42 play play VB cord-015021-pol2qm74 6669 43 a a DT cord-015021-pol2qm74 6669 44 major major JJ cord-015021-pol2qm74 6669 45 role role NN cord-015021-pol2qm74 6669 46 in in IN cord-015021-pol2qm74 6669 47 the the DT cord-015021-pol2qm74 6669 48 pathophysiology pathophysiology NN cord-015021-pol2qm74 6669 49 of of IN cord-015021-pol2qm74 6669 50 tissue tissue NN cord-015021-pol2qm74 6669 51 injury injury NN cord-015021-pol2qm74 6669 52 and and CC cord-015021-pol2qm74 6669 53 organ organ NN cord-015021-pol2qm74 6669 54 dysfunction dysfunction NN cord-015021-pol2qm74 6669 55 in in IN cord-015021-pol2qm74 6669 56 sepsis sepsis NN cord-015021-pol2qm74 6669 57 , , , cord-015021-pol2qm74 6669 58 through through IN cord-015021-pol2qm74 6669 59 induction induction NN cord-015021-pol2qm74 6669 60 of of IN cord-015021-pol2qm74 6669 61 lipid lipid NN cord-015021-pol2qm74 6669 62 pemxidation pemxidation NN cord-015021-pol2qm74 6669 63 in in IN cord-015021-pol2qm74 6669 64 cell cell NN cord-015021-pol2qm74 6669 65 membranes membrane NNS cord-015021-pol2qm74 6669 66 . . . cord-015021-pol2qm74 6670 1 Oxidative oxidative JJ cord-015021-pol2qm74 6670 2 damage damage NN cord-015021-pol2qm74 6670 3 can can MD cord-015021-pol2qm74 6670 4 result result VB cord-015021-pol2qm74 6670 5 both both DT cord-015021-pol2qm74 6670 6 to to IN cord-015021-pol2qm74 6670 7 an an DT cord-015021-pol2qm74 6670 8 OFR OFR NNP cord-015021-pol2qm74 6670 9 - - HYPH cord-015021-pol2qm74 6670 10 overpmduction overpmduction NN cord-015021-pol2qm74 6670 11 or or CC cord-015021-pol2qm74 6670 12 to to IN cord-015021-pol2qm74 6670 13 a a DT cord-015021-pol2qm74 6670 14 depletion depletion NN cord-015021-pol2qm74 6670 15 of of IN cord-015021-pol2qm74 6670 16 endogenous endogenous JJ cord-015021-pol2qm74 6670 17 antioxidant antioxidant JJ cord-015021-pol2qm74 6670 18 defenses defense NNS cord-015021-pol2qm74 6670 19 , , , cord-015021-pol2qm74 6670 20 which which WDT cord-015021-pol2qm74 6670 21 are be VBP cord-015021-pol2qm74 6670 22 represented represent VBN cord-015021-pol2qm74 6670 23 by by IN cord-015021-pol2qm74 6670 24 scavenger scavenger NN cord-015021-pol2qm74 6670 25 enzymes enzyme NNS cord-015021-pol2qm74 6670 26 ( ( -LRB- cord-015021-pol2qm74 6670 27 e.g. e.g. RB cord-015021-pol2qm74 6670 28 SOD SOD NNP cord-015021-pol2qm74 6670 29 ) ) -RRB- cord-015021-pol2qm74 6670 30 , , , cord-015021-pol2qm74 6670 31 hydrosoluble hydrosoluble JJ cord-015021-pol2qm74 6670 32 and and CC cord-015021-pol2qm74 6670 33 liposoluble liposoluble JJ cord-015021-pol2qm74 6670 34 antioxidants antioxidant NNS cord-015021-pol2qm74 6670 35 ( ( -LRB- cord-015021-pol2qm74 6670 36 e.g. e.g. RB cord-015021-pol2qm74 6670 37 ascorbate ascorbate NN cord-015021-pol2qm74 6670 38 , , , cord-015021-pol2qm74 6670 39 vitamin vitamin NN cord-015021-pol2qm74 6670 40 E e NN cord-015021-pol2qm74 6670 41 ) ) -RRB- cord-015021-pol2qm74 6670 42 , , , cord-015021-pol2qm74 6670 43 and and CC cord-015021-pol2qm74 6670 44 other other JJ cord-015021-pol2qm74 6670 45 mechanisms mechanism NNS cord-015021-pol2qm74 6670 46 such such JJ cord-015021-pol2qm74 6670 47 as as IN cord-015021-pol2qm74 6670 48 metal metal NN cord-015021-pol2qm74 6670 49 - - HYPH cord-015021-pol2qm74 6670 50 ion ion NN cord-015021-pol2qm74 6670 51 sequestration sequestration NN cord-015021-pol2qm74 6670 52 . . . cord-015021-pol2qm74 6671 1 In in IN cord-015021-pol2qm74 6671 2 animal animal NN cord-015021-pol2qm74 6671 3 models model NNS cord-015021-pol2qm74 6671 4 , , , cord-015021-pol2qm74 6671 5 oxidative oxidative JJ cord-015021-pol2qm74 6671 6 damage damage NN cord-015021-pol2qm74 6671 7 has have VBZ cord-015021-pol2qm74 6671 8 been be VBN cord-015021-pol2qm74 6671 9 proved prove VBN cord-015021-pol2qm74 6671 10 by by IN cord-015021-pol2qm74 6671 11 detection detection NN cord-015021-pol2qm74 6671 12 of of IN cord-015021-pol2qm74 6671 13 increased increase VBN cord-015021-pol2qm74 6671 14 levels level NNS cord-015021-pol2qm74 6671 15 of of IN cord-015021-pol2qm74 6671 16 lipoperoxidative lipoperoxidative JJ cord-015021-pol2qm74 6671 17 products product NNS cord-015021-pol2qm74 6671 18 , , , cord-015021-pol2qm74 6671 19 and and CC cord-015021-pol2qm74 6671 20 a a DT cord-015021-pol2qm74 6671 21 depletion depletion NN cord-015021-pol2qm74 6671 22 of of IN cord-015021-pol2qm74 6671 23 antioxidant antioxidant JJ cord-015021-pol2qm74 6671 24 defenses defense NNS cord-015021-pol2qm74 6671 25 was be VBD cord-015021-pol2qm74 6671 26 found find VBN cord-015021-pol2qm74 6671 27 both both CC cord-015021-pol2qm74 6671 28 in in IN cord-015021-pol2qm74 6671 29 plasma plasma NN cord-015021-pol2qm74 6671 30 and and CC cord-015021-pol2qm74 6671 31 tissues tissue NNS cord-015021-pol2qm74 6671 32 . . . cord-015021-pol2qm74 6672 1 In in IN cord-015021-pol2qm74 6672 2 the the DT cord-015021-pol2qm74 6672 3 few few JJ cord-015021-pol2qm74 6672 4 clinical clinical JJ cord-015021-pol2qm74 6672 5 studies study NNS cord-015021-pol2qm74 6672 6 a a DT cord-015021-pol2qm74 6672 7 similar similar JJ cord-015021-pol2qm74 6672 8 results result NNS cord-015021-pol2qm74 6672 9 have have VBP cord-015021-pol2qm74 6672 10 been be VBN cord-015021-pol2qm74 6672 11 reported report VBN cord-015021-pol2qm74 6672 12 , , , cord-015021-pol2qm74 6672 13 and and CC cord-015021-pol2qm74 6672 14 oxidative oxidative JJ cord-015021-pol2qm74 6672 15 damage damage NN cord-015021-pol2qm74 6672 16 appears appear VBZ cord-015021-pol2qm74 6672 17 to to TO cord-015021-pol2qm74 6672 18 correlate correlate VB cord-015021-pol2qm74 6672 19 with with IN cord-015021-pol2qm74 6672 20 DIC DIC NNP cord-015021-pol2qm74 6672 21 , , , cord-015021-pol2qm74 6672 22 with with IN cord-015021-pol2qm74 6672 23 organ organ NN cord-015021-pol2qm74 6672 24 dysfunction dysfunction NN cord-015021-pol2qm74 6672 25 and and CC cord-015021-pol2qm74 6672 26 with with IN cord-015021-pol2qm74 6672 27 red red JJ cord-015021-pol2qm74 6672 28 blood blood NN cord-015021-pol2qm74 6672 29 cell cell NN cord-015021-pol2qm74 6672 30 deformability deformability NN cord-015021-pol2qm74 6672 31 . . . cord-015021-pol2qm74 6673 1 In in IN cord-015021-pol2qm74 6673 2 a a DT cord-015021-pol2qm74 6673 3 group group NN cord-015021-pol2qm74 6673 4 of of IN cord-015021-pol2qm74 6673 5 critically critically RB cord-015021-pol2qm74 6673 6 ill ill JJ cord-015021-pol2qm74 6673 7 septic septic JJ cord-015021-pol2qm74 6673 8 patients patient NNS cord-015021-pol2qm74 6673 9 we -PRON- PRP cord-015021-pol2qm74 6673 10 found find VBD cord-015021-pol2qm74 6673 11 increased increase VBN cord-015021-pol2qm74 6673 12 levels level NNS cord-015021-pol2qm74 6673 13 of of IN cord-015021-pol2qm74 6673 14 conjugated conjugated JJ cord-015021-pol2qm74 6673 15 dienes diene NNS cord-015021-pol2qm74 6673 16 ( ( -LRB- cord-015021-pol2qm74 6673 17 CD CD NNP cord-015021-pol2qm74 6673 18 ) ) -RRB- cord-015021-pol2qm74 6673 19 ( ( -LRB- cord-015021-pol2qm74 6673 20 bioproducts bioproduct NNS cord-015021-pol2qm74 6673 21 of of IN cord-015021-pol2qm74 6673 22 lipoperoxidation lipoperoxidation NNP cord-015021-pol2qm74 6673 23 ) ) -RRB- cord-015021-pol2qm74 6673 24 and and CC cord-015021-pol2qm74 6673 25 decreased decrease VBD cord-015021-pol2qm74 6673 26 plasma plasma NN cord-015021-pol2qm74 6673 27 levels level NNS cord-015021-pol2qm74 6673 28 of of IN cord-015021-pol2qm74 6673 29 alpha alpha NN cord-015021-pol2qm74 6673 30 - - HYPH cord-015021-pol2qm74 6673 31 tocopherol tocopherol NN cord-015021-pol2qm74 6673 32 and and CC cord-015021-pol2qm74 6673 33 coenzyme coenzyme NN cord-015021-pol2qm74 6673 34 Qlo Qlo NNP cord-015021-pol2qm74 6673 35 ( ( -LRB- cord-015021-pol2qm74 6673 36 CoQI0)(endogenous coqi0)(endogenous JJ cord-015021-pol2qm74 6673 37 liposoluble liposoluble NNP cord-015021-pol2qm74 6673 38 antioxidants antioxidant NNS cord-015021-pol2qm74 6673 39 ) ) -RRB- cord-015021-pol2qm74 6673 40 . . . cord-015021-pol2qm74 6674 1 A a DT cord-015021-pol2qm74 6674 2 relationship relationship NN cord-015021-pol2qm74 6674 3 between between IN cord-015021-pol2qm74 6674 4 CD cd NN cord-015021-pol2qm74 6674 5 and and CC cord-015021-pol2qm74 6674 6 uric uric NN cord-015021-pol2qm74 6674 7 acid acid NN cord-015021-pol2qm74 6674 8 ( ( -LRB- cord-015021-pol2qm74 6674 9 p<0.004 p<0.004 CD cord-015021-pol2qm74 6674 10 ) ) -RRB- cord-015021-pol2qm74 6674 11 was be VBD cord-015021-pol2qm74 6674 12 found find VBN cord-015021-pol2qm74 6674 13 , , , cord-015021-pol2qm74 6674 14 may may MD cord-015021-pol2qm74 6674 15 be be VB cord-015021-pol2qm74 6674 16 related relate VBN cord-015021-pol2qm74 6674 17 to to IN cord-015021-pol2qm74 6674 18 xantine xantine NN cord-015021-pol2qm74 6674 19 - - HYPH cord-015021-pol2qm74 6674 20 dehydmgenase dehydmgenase NNP cord-015021-pol2qm74 6674 21 to to IN cord-015021-pol2qm74 6674 22 xantine xantine NN cord-015021-pol2qm74 6674 23 - - HYPH cord-015021-pol2qm74 6674 24 oxidase oxidase JJ cord-015021-pol2qm74 6674 25 conversion conversion NN cord-015021-pol2qm74 6674 26 . . . cord-015021-pol2qm74 6675 1 Antioxidant antioxidant JJ cord-015021-pol2qm74 6675 2 depletion depletion NN cord-015021-pol2qm74 6675 3 is be VBZ cord-015021-pol2qm74 6675 4 due due JJ cord-015021-pol2qm74 6675 5 both both DT cord-015021-pol2qm74 6675 6 to to IN cord-015021-pol2qm74 6675 7 overconsumption overconsumption NN cord-015021-pol2qm74 6675 8 and and CC cord-015021-pol2qm74 6675 9 to to IN cord-015021-pol2qm74 6675 10 a a DT cord-015021-pol2qm74 6675 11 nutritional nutritional JJ cord-015021-pol2qm74 6675 12 deficiency deficiency NN cord-015021-pol2qm74 6675 13 , , , cord-015021-pol2qm74 6675 14 even even RB cord-015021-pol2qm74 6675 15 if if IN cord-015021-pol2qm74 6675 16 a a DT cord-015021-pol2qm74 6675 17 reduced reduce VBN cord-015021-pol2qm74 6675 18 synthesis synthesis NN cord-015021-pol2qm74 6675 19 can can MD cord-015021-pol2qm74 6675 20 also also RB cord-015021-pol2qm74 6675 21 be be VB cord-015021-pol2qm74 6675 22 present present JJ cord-015021-pol2qm74 6675 23 . . . cord-015021-pol2qm74 6676 1 In in IN cord-015021-pol2qm74 6676 2 fact fact NN cord-015021-pol2qm74 6676 3 one one CD cord-015021-pol2qm74 6676 4 more more JJR cord-015021-pol2qm74 6676 5 relationship relationship NN cord-015021-pol2qm74 6676 6 between between IN cord-015021-pol2qm74 6676 7 CoQI0 CoQI0 NNP cord-015021-pol2qm74 6676 8 and and CC cord-015021-pol2qm74 6676 9 plasma plasma NN cord-015021-pol2qm74 6676 10 cholesterol cholesterol NN cord-015021-pol2qm74 6676 11 ( ( -LRB- cord-015021-pol2qm74 6676 12 p<0.0005 p<0.0005 NN cord-015021-pol2qm74 6676 13 ) ) -RRB- cord-015021-pol2qm74 6676 14 demonstrates demonstrate VBZ cord-015021-pol2qm74 6676 15 the the DT cord-015021-pol2qm74 6676 16 commun commun NNP cord-015021-pol2qm74 6676 17 hepatic hepatic JJ cord-015021-pol2qm74 6676 18 biosynthetic biosynthetic JJ cord-015021-pol2qm74 6676 19 defect defect NN cord-015021-pol2qm74 6676 20 . . . cord-015021-pol2qm74 6677 1 Is be VBZ cord-015021-pol2qm74 6677 2 there there EX cord-015021-pol2qm74 6677 3 any any DT cord-015021-pol2qm74 6677 4 role role NN cord-015021-pol2qm74 6677 5 for for IN cord-015021-pol2qm74 6677 6 antioxidative antioxidative JJ cord-015021-pol2qm74 6677 7 therapy therapy NN cord-015021-pol2qm74 6677 8 in in IN cord-015021-pol2qm74 6677 9 sepsis sepsis NN cord-015021-pol2qm74 6677 10 ? ? . cord-015021-pol2qm74 6678 1 Can Can MD cord-015021-pol2qm74 6678 2 it -PRON- PRP cord-015021-pol2qm74 6678 3 achives achive VBZ cord-015021-pol2qm74 6678 4 a a DT cord-015021-pol2qm74 6678 5 significant significant JJ cord-015021-pol2qm74 6678 6 improvement improvement NN cord-015021-pol2qm74 6678 7 in in IN cord-015021-pol2qm74 6678 8 the the DT cord-015021-pol2qm74 6678 9 septic septic JJ cord-015021-pol2qm74 6678 10 course course NN cord-015021-pol2qm74 6678 11 , , , cord-015021-pol2qm74 6678 12 organ organ NN cord-015021-pol2qm74 6678 13 dysfunction dysfunction NN cord-015021-pol2qm74 6678 14 , , , cord-015021-pol2qm74 6678 15 and and CC cord-015021-pol2qm74 6678 16 final final JJ cord-015021-pol2qm74 6678 17 outcome outcome NN cord-015021-pol2qm74 6678 18 ? ? . cord-015021-pol2qm74 6679 1 Several several JJ cord-015021-pol2qm74 6679 2 antioxidant antioxidant JJ cord-015021-pol2qm74 6679 3 drugs drug NNS cord-015021-pol2qm74 6679 4 , , , cord-015021-pol2qm74 6679 5 have have VBP cord-015021-pol2qm74 6679 6 been be VBN cord-015021-pol2qm74 6679 7 evaluated evaluate VBN cord-015021-pol2qm74 6679 8 in in IN cord-015021-pol2qm74 6679 9 experimental experimental JJ cord-015021-pol2qm74 6679 10 and and CC cord-015021-pol2qm74 6679 11 clinical clinical JJ cord-015021-pol2qm74 6679 12 sepsis sepsis NN cord-015021-pol2qm74 6679 13 : : : cord-015021-pol2qm74 6679 14 scavenger scavenger NN cord-015021-pol2qm74 6679 15 enzymes enzyme NNS cord-015021-pol2qm74 6679 16 , , , cord-015021-pol2qm74 6679 17 natural natural JJ cord-015021-pol2qm74 6679 18 antioxidants antioxidant NNS cord-015021-pol2qm74 6679 19 , , , cord-015021-pol2qm74 6679 20 alloporinol alloporinol NN cord-015021-pol2qm74 6679 21 , , , cord-015021-pol2qm74 6679 22 21-aminosteroids 21-aminosteroids CD cord-015021-pol2qm74 6679 23 or or CC cord-015021-pol2qm74 6679 24 lazaroids lazaroid NNS cord-015021-pol2qm74 6679 25 , , , cord-015021-pol2qm74 6679 26 have have VBP cord-015021-pol2qm74 6679 27 been be VBN cord-015021-pol2qm74 6679 28 proved prove VBN cord-015021-pol2qm74 6679 29 to to TO cord-015021-pol2qm74 6679 30 reduce reduce VB cord-015021-pol2qm74 6679 31 lipopemxidative lipopemxidative JJ cord-015021-pol2qm74 6679 32 damage damage NN cord-015021-pol2qm74 6679 33 , , , cord-015021-pol2qm74 6679 34 to to TO cord-015021-pol2qm74 6679 35 protect protect VB cord-015021-pol2qm74 6679 36 organ organ NN cord-015021-pol2qm74 6679 37 dysfunction dysfunction NN cord-015021-pol2qm74 6679 38 , , , cord-015021-pol2qm74 6679 39 and and CC cord-015021-pol2qm74 6679 40 in in IN cord-015021-pol2qm74 6679 41 some some DT cord-015021-pol2qm74 6679 42 cases case NNS cord-015021-pol2qm74 6679 43 to to TO cord-015021-pol2qm74 6679 44 improve improve VB cord-015021-pol2qm74 6679 45 survival survival NN cord-015021-pol2qm74 6679 46 . . . cord-015021-pol2qm74 6680 1 Several several JJ cord-015021-pol2qm74 6680 2 questions question NNS cord-015021-pol2qm74 6680 3 must must MD cord-015021-pol2qm74 6680 4 be be VB cord-015021-pol2qm74 6680 5 addressed address VBN cord-015021-pol2qm74 6680 6 in in IN cord-015021-pol2qm74 6680 7 evaluating evaluate VBG cord-015021-pol2qm74 6680 8 safety safety NN cord-015021-pol2qm74 6680 9 and and CC cord-015021-pol2qm74 6680 10 utility utility NN cord-015021-pol2qm74 6680 11 of of IN cord-015021-pol2qm74 6680 12 antioxidative antioxidative JJ cord-015021-pol2qm74 6680 13 therapy therapy NN cord-015021-pol2qm74 6680 14 . . . cord-015021-pol2qm74 6681 1 More more RBR cord-015021-pol2qm74 6681 2 specific specific JJ cord-015021-pol2qm74 6681 3 and and CC cord-015021-pol2qm74 6681 4 standardized standardized JJ cord-015021-pol2qm74 6681 5 methods method NNS cord-015021-pol2qm74 6681 6 must must MD cord-015021-pol2qm74 6681 7 be be VB cord-015021-pol2qm74 6681 8 applied apply VBN cord-015021-pol2qm74 6681 9 to to TO cord-015021-pol2qm74 6681 10 detect detect VB cord-015021-pol2qm74 6681 11 and and CC cord-015021-pol2qm74 6681 12 quantify quantify VB cord-015021-pol2qm74 6681 13 the the DT cord-015021-pol2qm74 6681 14 lipoperoxidative lipoperoxidative JJ cord-015021-pol2qm74 6681 15 damage damage NN cord-015021-pol2qm74 6681 16 . . . cord-015021-pol2qm74 6682 1 Antioxidant antioxidant NN cord-015021-pol2qm74 6682 2 drags drag VBZ cord-015021-pol2qm74 6682 3 must must MD cord-015021-pol2qm74 6682 4 act act VB cord-015021-pol2qm74 6682 5 selectively selectively RB cord-015021-pol2qm74 6682 6 on on IN cord-015021-pol2qm74 6682 7 OFR ofr NN cord-015021-pol2qm74 6682 8 - - HYPH cord-015021-pol2qm74 6682 9 production production NN cord-015021-pol2qm74 6682 10 , , , cord-015021-pol2qm74 6682 11 without without IN cord-015021-pol2qm74 6682 12 interference interference NN cord-015021-pol2qm74 6682 13 with with IN cord-015021-pol2qm74 6682 14 other other JJ cord-015021-pol2qm74 6682 15 than than IN cord-015021-pol2qm74 6683 1 that that WDT cord-015021-pol2qm74 6683 2 are be VBP cord-015021-pol2qm74 6683 3 beneficial beneficial JJ cord-015021-pol2qm74 6683 4 for for IN cord-015021-pol2qm74 6683 5 the the DT cord-015021-pol2qm74 6683 6 organism organism NN cord-015021-pol2qm74 6683 7 . . . cord-015021-pol2qm74 6684 1 Antioxidants antioxidant NNS cord-015021-pol2qm74 6684 2 must must MD cord-015021-pol2qm74 6684 3 be be VB cord-015021-pol2qm74 6684 4 able able JJ cord-015021-pol2qm74 6684 5 to to TO cord-015021-pol2qm74 6684 6 achive achive VB cord-015021-pol2qm74 6684 7 in in IN cord-015021-pol2qm74 6684 8 adequate adequate JJ cord-015021-pol2qm74 6684 9 amount amount NN cord-015021-pol2qm74 6684 10 the the DT cord-015021-pol2qm74 6684 11 tissue tissue NN cord-015021-pol2qm74 6684 12 or or CC cord-015021-pol2qm74 6684 13 cellular cellular JJ cord-015021-pol2qm74 6684 14 compartment compartment NN cord-015021-pol2qm74 6684 15 where where WRB cord-015021-pol2qm74 6684 16 their -PRON- PRP$ cord-015021-pol2qm74 6684 17 action action NN cord-015021-pol2qm74 6684 18 is be VBZ cord-015021-pol2qm74 6684 19 required require VBN cord-015021-pol2qm74 6684 20 . . . cord-015021-pol2qm74 6685 1 Many many JJ cord-015021-pol2qm74 6685 2 antioxidants antioxidant NNS cord-015021-pol2qm74 6685 3 have have VBP cord-015021-pol2qm74 6685 4 also also RB cord-015021-pol2qm74 6685 5 a a DT cord-015021-pol2qm74 6685 6 pro pro JJ cord-015021-pol2qm74 6685 7 - - JJ cord-015021-pol2qm74 6685 8 oxidative oxidative JJ cord-015021-pol2qm74 6685 9 effect effect NN cord-015021-pol2qm74 6685 10 which which WDT cord-015021-pol2qm74 6685 11 can can MD cord-015021-pol2qm74 6685 12 he -PRON- PRP cord-015021-pol2qm74 6685 13 detrimental detrimental VB cord-015021-pol2qm74 6685 14 in in IN cord-015021-pol2qm74 6685 15 some some DT cord-015021-pol2qm74 6685 16 conditions condition NNS cord-015021-pol2qm74 6685 17 . . . cord-015021-pol2qm74 6686 1 The the DT cord-015021-pol2qm74 6686 2 timing timing NN cord-015021-pol2qm74 6686 3 of of IN cord-015021-pol2qm74 6686 4 administration administration NN cord-015021-pol2qm74 6686 5 , , , cord-015021-pol2qm74 6686 6 the the DT cord-015021-pol2qm74 6686 7 dosage dosage NN cord-015021-pol2qm74 6686 8 used use VBN cord-015021-pol2qm74 6686 9 and and CC cord-015021-pol2qm74 6686 10 the the DT cord-015021-pol2qm74 6686 11 association association NN cord-015021-pol2qm74 6686 12 wih wih IN cord-015021-pol2qm74 6686 13 others other NNS cord-015021-pol2qm74 6686 14 antioxidant antioxidant JJ cord-015021-pol2qm74 6686 15 drugs drug NNS cord-015021-pol2qm74 6686 16 must must MD cord-015021-pol2qm74 6686 17 be be VB cord-015021-pol2qm74 6686 18 defined define VBN cord-015021-pol2qm74 6686 19 . . . cord-015021-pol2qm74 6687 1 Nutrition nutrition NN cord-015021-pol2qm74 6687 2 plays play VBZ cord-015021-pol2qm74 6687 3 an an DT cord-015021-pol2qm74 6687 4 important important JJ cord-015021-pol2qm74 6687 5 role role NN cord-015021-pol2qm74 6687 6 as as IN cord-015021-pol2qm74 6687 7 antioxidative antioxidative JJ cord-015021-pol2qm74 6687 8 therapy therapy NN cord-015021-pol2qm74 6687 9 , , , cord-015021-pol2qm74 6687 10 since since IN cord-015021-pol2qm74 6687 11 it -PRON- PRP cord-015021-pol2qm74 6687 12 supplies supply VBZ cord-015021-pol2qm74 6687 13 all all DT cord-015021-pol2qm74 6687 14 compounds compound NNS cord-015021-pol2qm74 6687 15 needed need VBN cord-015021-pol2qm74 6687 16 to to TO cord-015021-pol2qm74 6687 17 maintain maintain VB cord-015021-pol2qm74 6687 18 adequately adequately RB cord-015021-pol2qm74 6687 19 levels level NNS cord-015021-pol2qm74 6687 20 of of IN cord-015021-pol2qm74 6687 21 endogenous endogenous JJ cord-015021-pol2qm74 6687 22 antioxidant antioxidant NN cord-015021-pol2qm74 6687 23 or or CC cord-015021-pol2qm74 6687 24 to to TO cord-015021-pol2qm74 6687 25 support support VB cord-015021-pol2qm74 6687 26 their -PRON- PRP$ cord-015021-pol2qm74 6687 27 synthesis synthesis NN cord-015021-pol2qm74 6687 28 . . . cord-015021-pol2qm74 6688 1 Thiobarbituric thiobarbituric JJ cord-015021-pol2qm74 6688 2 acid acid NN cord-015021-pol2qm74 6688 3 reactive reactive JJ cord-015021-pol2qm74 6688 4 substances substance NNS cord-015021-pol2qm74 6689 1 ( ( -LRB- cord-015021-pol2qm74 6689 2 TBARS TBARS NNP cord-015021-pol2qm74 6689 3 ) ) -RRB- cord-015021-pol2qm74 6689 4 concentration concentration NN cord-015021-pol2qm74 6689 5 in in IN cord-015021-pol2qm74 6689 6 serum serum NN cord-015021-pol2qm74 6689 7 has have VBZ cord-015021-pol2qm74 6689 8 been be VBN cord-015021-pol2qm74 6689 9 determined determine VBN cord-015021-pol2qm74 6689 10 in in IN cord-015021-pol2qm74 6689 11 a a DT cord-015021-pol2qm74 6689 12 large large JJ cord-015021-pol2qm74 6689 13 population population NN cord-015021-pol2qm74 6689 14 of of IN cord-015021-pol2qm74 6689 15 healthy healthy JJ cord-015021-pol2qm74 6689 16 subjects subject NNS cord-015021-pol2qm74 6689 17 and and CC cord-015021-pol2qm74 6689 18 in in IN cord-015021-pol2qm74 6689 19 patients patient NNS cord-015021-pol2qm74 6689 20 suffering suffer VBG cord-015021-pol2qm74 6689 21 acute acute JJ cord-015021-pol2qm74 6689 22 hepatitis hepatitis NN cord-015021-pol2qm74 6689 23 and and CC cord-015021-pol2qm74 6689 24 chronic chronic JJ cord-015021-pol2qm74 6689 25 cases case NNS cord-015021-pol2qm74 6689 26 of of IN cord-015021-pol2qm74 6689 27 hepatitis hepatitis NN cord-015021-pol2qm74 6689 28 C C NNP cord-015021-pol2qm74 6689 29 , , , cord-015021-pol2qm74 6689 30 as as RB cord-015021-pol2qm74 6689 31 well well RB cord-015021-pol2qm74 6689 32 as as IN cord-015021-pol2qm74 6689 33 several several JJ cord-015021-pol2qm74 6689 34 other other JJ cord-015021-pol2qm74 6689 35 processes process NNS cord-015021-pol2qm74 6689 36 . . . cord-015021-pol2qm74 6690 1 The the DT cord-015021-pol2qm74 6690 2 correlation correlation NN cord-015021-pol2qm74 6690 3 with with IN cord-015021-pol2qm74 6690 4 different different JJ cord-015021-pol2qm74 6690 5 physiological physiological JJ cord-015021-pol2qm74 6690 6 and and CC cord-015021-pol2qm74 6690 7 clinical clinical JJ cord-015021-pol2qm74 6690 8 parameters parameter NNS cord-015021-pol2qm74 6690 9 in in IN cord-015021-pol2qm74 6690 10 these these DT cord-015021-pol2qm74 6690 11 populations population NNS cord-015021-pol2qm74 6690 12 is be VBZ cord-015021-pol2qm74 6690 13 also also RB cord-015021-pol2qm74 6690 14 presented present VBN cord-015021-pol2qm74 6690 15 . . . cord-015021-pol2qm74 6691 1 Treatment treatment NN cord-015021-pol2qm74 6691 2 with with IN cord-015021-pol2qm74 6691 3 interferon interferon NN cord-015021-pol2qm74 6691 4 of of IN cord-015021-pol2qm74 6691 5 the the DT cord-015021-pol2qm74 6691 6 chronic chronic JJ cord-015021-pol2qm74 6691 7 active active JJ cord-015021-pol2qm74 6691 8 hepatitis hepatitis NN cord-015021-pol2qm74 6691 9 C C NNP cord-015021-pol2qm74 6691 10 patients patient NNS cord-015021-pol2qm74 6691 11 , , , cord-015021-pol2qm74 6691 12 5x10 5x10 CD cord-015021-pol2qm74 6691 13 U U NNP cord-015021-pol2qm74 6691 14 three three CD cord-015021-pol2qm74 6691 15 times time NNS cord-015021-pol2qm74 6691 16 a a DT cord-015021-pol2qm74 6691 17 week week NN cord-015021-pol2qm74 6691 18 during during IN cord-015021-pol2qm74 6691 19 two two CD cord-015021-pol2qm74 6691 20 months month NNS cord-015021-pol2qm74 6691 21 , , , cord-015021-pol2qm74 6691 22 led lead VBN cord-015021-pol2qm74 6691 23 in in IN cord-015021-pol2qm74 6691 24 those those DT cord-015021-pol2qm74 6691 25 patients patient NNS cord-015021-pol2qm74 6691 26 whose whose WP$ cord-015021-pol2qm74 6691 27 SGPT SGPT NNP cord-015021-pol2qm74 6691 28 activity activity NN cord-015021-pol2qm74 6691 29 normalized normalize VBN cord-015021-pol2qm74 6691 30 in in IN cord-015021-pol2qm74 6691 31 serum serum NN cord-015021-pol2qm74 6691 32 , , , cord-015021-pol2qm74 6691 33 to to IN cord-015021-pol2qm74 6691 34 a a DT cord-015021-pol2qm74 6691 35 concomitant concomitant JJ cord-015021-pol2qm74 6691 36 decrease decrease NN cord-015021-pol2qm74 6691 37 in in IN cord-015021-pol2qm74 6691 38 serum serum NN cord-015021-pol2qm74 6691 39 TBARS tbars NN cord-015021-pol2qm74 6691 40 content content NN cord-015021-pol2qm74 6691 41 . . . cord-015021-pol2qm74 6692 1 The the DT cord-015021-pol2qm74 6692 2 possible possible JJ cord-015021-pol2qm74 6692 3 theoretical theoretical JJ cord-015021-pol2qm74 6692 4 involvement involvement NN cord-015021-pol2qm74 6692 5 of of IN cord-015021-pol2qm74 6692 6 peroxidation peroxidation NN cord-015021-pol2qm74 6692 7 and and CC cord-015021-pol2qm74 6692 8 antioxidants antioxidant NNS cord-015021-pol2qm74 6692 9 in in IN cord-015021-pol2qm74 6692 10 this this DT cord-015021-pol2qm74 6692 11 beneficial beneficial JJ cord-015021-pol2qm74 6692 12 effect effect NN cord-015021-pol2qm74 6692 13 of of IN cord-015021-pol2qm74 6692 14 i i PRP cord-015021-pol2qm74 6692 15 ~ ~ NFP cord-015021-pol2qm74 6692 16 terferon terferon NNP cord-015021-pol2qm74 6692 17 in in IN cord-015021-pol2qm74 6692 18 hepatitis hepatitis NN cord-015021-pol2qm74 6692 19 C C NNP cord-015021-pol2qm74 6692 20 patients patient NNS cord-015021-pol2qm74 6692 21 is be VBZ cord-015021-pol2qm74 6692 22 discussed discuss VBN cord-015021-pol2qm74 6692 23 . . . cord-015021-pol2qm74 6693 1 The the DT cord-015021-pol2qm74 6693 2 results result NNS cord-015021-pol2qm74 6693 3 presented present VBN cord-015021-pol2qm74 6693 4 confirm confirm VBP cord-015021-pol2qm74 6693 5 the the DT cord-015021-pol2qm74 6693 6 value value NN cord-015021-pol2qm74 6693 7 of of IN cord-015021-pol2qm74 6693 8 TBARS TBARS NNP cord-015021-pol2qm74 6693 9 as as IN cord-015021-pol2qm74 6693 10 laboratory laboratory NN cord-015021-pol2qm74 6693 11 test test NN cord-015021-pol2qm74 6693 12 in in IN cord-015021-pol2qm74 6693 13 the the DT cord-015021-pol2qm74 6693 14 management management NN cord-015021-pol2qm74 6693 15 of of IN cord-015021-pol2qm74 6693 16 disease disease NN cord-015021-pol2qm74 6693 17 and and CC cord-015021-pol2qm74 6693 18 as as IN cord-015021-pol2qm74 6693 19 a a DT cord-015021-pol2qm74 6693 20 useful useful JJ cord-015021-pol2qm74 6693 21 tool tool NN cord-015021-pol2qm74 6693 22 for for IN cord-015021-pol2qm74 6693 23 the the DT cord-015021-pol2qm74 6693 24 study study NN cord-015021-pol2qm74 6693 25 of of IN cord-015021-pol2qm74 6693 26 pathogenic pathogenic JJ cord-015021-pol2qm74 6693 27 and/or and/or CC cord-015021-pol2qm74 6693 28 therapeutic therapeutic JJ cord-015021-pol2qm74 6693 29 mechanisms mechanism NNS cord-015021-pol2qm74 6693 30 . . . cord-015021-pol2qm74 6694 1 4-Hydroxyalkenals 4-hydroxyalkenals CD cord-015021-pol2qm74 6694 2 are be VBP cord-015021-pol2qm74 6694 3 among among IN cord-015021-pol2qm74 6694 4 the the DT cord-015021-pol2qm74 6694 5 different different JJ cord-015021-pol2qm74 6694 6 substances substance NNS cord-015021-pol2qm74 6694 7 measured measure VBN cord-015021-pol2qm74 6694 8 by by IN cord-015021-pol2qm74 6694 9 the the DT cord-015021-pol2qm74 6694 10 TBARS TBARS NNP cord-015021-pol2qm74 6694 11 assay assay NN cord-015021-pol2qm74 6694 12 . . . cord-015021-pol2qm74 6695 1 These these DT cord-015021-pol2qm74 6695 2 compounds compound NNS cord-015021-pol2qm74 6695 3 show show VBP cord-015021-pol2qm74 6695 4 several several JJ cord-015021-pol2qm74 6695 5 biological biological JJ cord-015021-pol2qm74 6695 6 effects effect NNS cord-015021-pol2qm74 6695 7 that that WDT cord-015021-pol2qm74 6695 8 have have VBP cord-015021-pol2qm74 6695 9 been be VBN cord-015021-pol2qm74 6695 10 demonstrated demonstrate VBN cord-015021-pol2qm74 6695 11 mainly mainly RB cord-015021-pol2qm74 6695 12 in in IN cord-015021-pol2qm74 6695 13 different different JJ cord-015021-pol2qm74 6695 14 experimental experimental JJ cord-015021-pol2qm74 6695 15 models model NNS cord-015021-pol2qm74 6695 16 . . . cord-015021-pol2qm74 6696 1 We -PRON- PRP cord-015021-pol2qm74 6696 2 have have VBP cord-015021-pol2qm74 6696 3 studied study VBN cord-015021-pol2qm74 6696 4 the the DT cord-015021-pol2qm74 6696 5 capacity capacity NN cord-015021-pol2qm74 6696 6 of of IN cord-015021-pol2qm74 6696 7 different different JJ cord-015021-pol2qm74 6696 8 tissues tissue NNS cord-015021-pol2qm74 6696 9 to to TO cord-015021-pol2qm74 6696 10 conjugate conjugate VB cord-015021-pol2qm74 6696 11 these these DT cord-015021-pol2qm74 6696 12 compounds compound NNS cord-015021-pol2qm74 6696 13 _SP cord-015021-pol2qm74 6696 14 Patients patient NNS cord-015021-pol2qm74 6696 15 surviving survive VBG cord-015021-pol2qm74 6696 16 the the DT cord-015021-pol2qm74 6696 17 initial initial JJ cord-015021-pol2qm74 6696 18 subarachnoid subarachnoid NN cord-015021-pol2qm74 6696 19 hemorrhage hemorrhage NN cord-015021-pol2qm74 6696 20 ( ( -LRB- cord-015021-pol2qm74 6696 21 SAH SAH NNP cord-015021-pol2qm74 6696 22 ) ) -RRB- cord-015021-pol2qm74 6696 23 from from IN cord-015021-pol2qm74 6696 24 a a DT cord-015021-pol2qm74 6696 25 ruptured ruptured NN cord-015021-pol2qm74 6696 26 in in IN cord-015021-pol2qm74 6696 27 ~ ~ CD cord-015021-pol2qm74 6696 28 raeranial raeranial JJ cord-015021-pol2qm74 6696 29 aneurysm aneurysm NNP cord-015021-pol2qm74 6696 30 are be VBP cord-015021-pol2qm74 6696 31 prone prone JJ cord-015021-pol2qm74 6696 32 to to TO cord-015021-pol2qm74 6696 33 develop develop VB cord-015021-pol2qm74 6696 34 cerebra cerebra NN cord-015021-pol2qm74 6696 35 ] ] -RRB- cord-015021-pol2qm74 6696 36 ischemia ischemia NN cord-015021-pol2qm74 6696 37 from from IN cord-015021-pol2qm74 6696 38 vasospasm vasospasm NN cord-015021-pol2qm74 6696 39 which which WDT cord-015021-pol2qm74 6696 40 is be VBZ cord-015021-pol2qm74 6696 41 associated associate VBN cord-015021-pol2qm74 6696 42 with with IN cord-015021-pol2qm74 6696 43 significant significant JJ cord-015021-pol2qm74 6696 44 morbidity morbidity NN cord-015021-pol2qm74 6696 45 and and CC cord-015021-pol2qm74 6696 46 mortality mortality NN cord-015021-pol2qm74 6696 47 . . . cord-015021-pol2qm74 6697 1 Among among IN cord-015021-pol2qm74 6697 2 the the DT cord-015021-pol2qm74 6697 3 many many JJ cord-015021-pol2qm74 6697 4 treatments treatment NNS cord-015021-pol2qm74 6697 5 that that WDT cord-015021-pol2qm74 6697 6 have have VBP cord-015021-pol2qm74 6697 7 been be VBN cord-015021-pol2qm74 6697 8 prol prol NNP cord-015021-pol2qm74 6697 9 ~ ~ NFP cord-015021-pol2qm74 6697 10 osed ose VBN cord-015021-pol2qm74 6697 11 to to TO cord-015021-pol2qm74 6697 12 treat treat VB cord-015021-pol2qm74 6697 13 this this DT cord-015021-pol2qm74 6697 14 condition condition NN cord-015021-pol2qm74 6697 15 , , , cord-015021-pol2qm74 6697 16 none none NN cord-015021-pol2qm74 6697 17 has have VBZ cord-015021-pol2qm74 6697 18 been be VBN cord-015021-pol2qm74 6697 19 shown show VBN cord-015021-pol2qm74 6697 20 to to TO cord-015021-pol2qm74 6697 21 be be VB cord-015021-pol2qm74 6697 22 satisfactorily satisfactorily RB cord-015021-pol2qm74 6697 23 effective effective JJ cord-015021-pol2qm74 6697 24 . . . cord-015021-pol2qm74 6698 1 Recently recently RB cord-015021-pol2qm74 6698 2 , , , cord-015021-pol2qm74 6698 3 a a DT cord-015021-pol2qm74 6698 4 new new JJ cord-015021-pol2qm74 6698 5 drug drug NN cord-015021-pol2qm74 6698 6 , , , cord-015021-pol2qm74 6698 7 namely namely RB cord-015021-pol2qm74 6698 8 the the DT cord-015021-pol2qm74 6698 9 21-aminosteroid 21-aminosteroid CD cord-015021-pol2qm74 6698 10 Tirilazadmesylats Tirilazadmesylats NNPS cord-015021-pol2qm74 6698 11 , , , cord-015021-pol2qm74 6698 12 has have VBZ cord-015021-pol2qm74 6698 13 been be VBN cord-015021-pol2qm74 6698 14 studied study VBN cord-015021-pol2qm74 6698 15 in in IN cord-015021-pol2qm74 6698 16 a a DT cord-015021-pol2qm74 6698 17 large large JJ cord-015021-pol2qm74 6698 18 , , , cord-015021-pol2qm74 6698 19 prospective prospective JJ cord-015021-pol2qm74 6698 20 , , , cord-015021-pol2qm74 6698 21 multicentor multicentor NN cord-015021-pol2qm74 6698 22 trial trial NN cord-015021-pol2qm74 6698 23 for for IN cord-015021-pol2qm74 6698 24 its -PRON- PRP$ cord-015021-pol2qm74 6698 25 effectiveness effectiveness NN cord-015021-pol2qm74 6698 26 to to TO cord-015021-pol2qm74 6698 27 improve improve VB cord-015021-pol2qm74 6698 28 the the DT cord-015021-pol2qm74 6698 29 outcome outcome NN cord-015021-pol2qm74 6698 30 of of IN cord-015021-pol2qm74 6698 31 patients patient NNS cord-015021-pol2qm74 6698 32 with with IN cord-015021-pol2qm74 6698 33 aneurysma aneurysma NNP cord-015021-pol2qm74 6698 34 ! ! . cord-015021-pol2qm74 6699 1 SAId SAId NNP cord-015021-pol2qm74 6699 2 . . . cord-015021-pol2qm74 6700 1 The the DT cord-015021-pol2qm74 6700 2 study study NN cord-015021-pol2qm74 6700 3 was be VBD cord-015021-pol2qm74 6700 4 conducted conduct VBN cord-015021-pol2qm74 6700 5 in in IN cord-015021-pol2qm74 6700 6 Europe Europe NNP cord-015021-pol2qm74 6700 7 and and CC cord-015021-pol2qm74 6700 8 Australia Australia NNP cord-015021-pol2qm74 6700 9 in in IN cord-015021-pol2qm74 6700 10 41 41 CD cord-015021-pol2qm74 6700 11 neurosurgical neurosurgical JJ cord-015021-pol2qm74 6700 12 centers center NNS cord-015021-pol2qm74 6700 13 and and CC cord-015021-pol2qm74 6700 14 included include VBD cord-015021-pol2qm74 6700 15 1023 1023 CD cord-015021-pol2qm74 6700 16 patients patient NNS cord-015021-pol2qm74 6700 17 . . . cord-015021-pol2qm74 6701 1 All all DT cord-015021-pol2qm74 6701 2 patients patient NNS cord-015021-pol2qm74 6701 3 received receive VBD cord-015021-pol2qm74 6701 4 presently presently RB cord-015021-pol2qm74 6701 5 accepted accept VBN cord-015021-pol2qm74 6701 6 standard standard JJ cord-015021-pol2qm74 6701 7 treatment treatment NN cord-015021-pol2qm74 6701 8 , , , cord-015021-pol2qm74 6701 9 including include VBG cord-015021-pol2qm74 6701 10 nimodipine nimodipine NN cord-015021-pol2qm74 6701 11 . . . cord-015021-pol2qm74 6702 1 Patients patient NNS cord-015021-pol2qm74 6702 2 were be VBD cord-015021-pol2qm74 6702 3 randomized randomize VBN cord-015021-pol2qm74 6702 4 to to IN cord-015021-pol2qm74 6702 5 four four CD cord-015021-pol2qm74 6702 6 different different JJ cord-015021-pol2qm74 6702 7 groups group NNS cord-015021-pol2qm74 6702 8 : : : cord-015021-pol2qm74 6702 9 placebo placebo NN cord-015021-pol2qm74 6702 10 and and CC cord-015021-pol2qm74 6702 11 8 8 CD cord-015021-pol2qm74 6702 12 groups group NNS cord-015021-pol2qm74 6702 13 of of IN cord-015021-pol2qm74 6702 14 tirilazad tirilazad NNP cord-015021-pol2qm74 6702 15 in in IN cord-015021-pol2qm74 6702 16 escalating escalate VBG cord-015021-pol2qm74 6702 17 dosage dosage NN cord-015021-pol2qm74 6702 18 ( ( -LRB- cord-015021-pol2qm74 6702 19 0.6 0.6 CD cord-015021-pol2qm74 6702 20 -6 -6 CD cord-015021-pol2qm74 6702 21 mg mg NNP cord-015021-pol2qm74 6702 22 / / SYM cord-015021-pol2qm74 6702 23 kg kg NNP cord-015021-pol2qm74 6702 24 / / SYM cord-015021-pol2qm74 6702 25 day day NN cord-015021-pol2qm74 6702 26 ) ) -RRB- cord-015021-pol2qm74 6702 27 . . . cord-015021-pol2qm74 6703 1 The the DT cord-015021-pol2qm74 6703 2 clinical clinical JJ cord-015021-pol2qm74 6703 3 outcome outcome NN cord-015021-pol2qm74 6703 4 was be VBD cord-015021-pol2qm74 6703 5 compared compare VBN cord-015021-pol2qm74 6703 6 for for IN cord-015021-pol2qm74 6703 7 these these DT cord-015021-pol2qm74 6703 8 4 4 CD cord-015021-pol2qm74 6703 9 groups group NNS cord-015021-pol2qm74 6703 10 and and CC cord-015021-pol2qm74 6703 11 cerebral cerebral JJ cord-015021-pol2qm74 6703 12 a a DT cord-015021-pol2qm74 6703 13 ~ ~ NFP cord-015021-pol2qm74 6703 14 giography giography NNP cord-015021-pol2qm74 6703 15 was be VBD cord-015021-pol2qm74 6703 16 performed perform VBN cord-015021-pol2qm74 6703 17 in in IN cord-015021-pol2qm74 6703 18 75 75 CD cord-015021-pol2qm74 6703 19 % % NN cord-015021-pol2qm74 6703 20 of of IN cord-015021-pol2qm74 6703 21 patients patient NNS cord-015021-pol2qm74 6703 22 on on IN cord-015021-pol2qm74 6703 23 day day NN cord-015021-pol2qm74 6703 24 7 7 CD cord-015021-pol2qm74 6703 25 -11 -11 NN cord-015021-pol2qm74 6703 26 follovang follovang NNP cord-015021-pol2qm74 6703 27 SAH SAH NNP cord-015021-pol2qm74 6703 28 , , , cord-015021-pol2qm74 6703 29 to to TO cord-015021-pol2qm74 6703 30 study study VB cord-015021-pol2qm74 6703 31 the the DT cord-015021-pol2qm74 6703 32 effect effect NN cord-015021-pol2qm74 6703 33 0f'the 0f'the CD cord-015021-pol2qm74 6703 34 dflf~ dflf~ NNP cord-015021-pol2qm74 6703 35 off off RP cord-015021-pol2qm74 6703 36 Cerebral cerebral JJ cord-015021-pol2qm74 6703 37 vasospasm vasospasm NN cord-015021-pol2qm74 6703 38 . . . cord-015021-pol2qm74 6704 1 The the DT cord-015021-pol2qm74 6704 2 study study NN cord-015021-pol2qm74 6704 3 reached reach VBD cord-015021-pol2qm74 6704 4 its -PRON- PRP$ cord-015021-pol2qm74 6704 5 planned planned JJ cord-015021-pol2qm74 6704 6 endpoint endpoint NN cord-015021-pol2qm74 6704 7 6 6 CD cord-015021-pol2qm74 6704 8 months month NNS cord-015021-pol2qm74 6704 9 ago ago RB cord-015021-pol2qm74 6704 10 . . . cord-015021-pol2qm74 6705 1 Preliminary preliminary JJ cord-015021-pol2qm74 6705 2 results result VBZ cord-015021-pol2qm74 6705 3 ~how ~how NNP cord-015021-pol2qm74 6705 4 a a DT cord-015021-pol2qm74 6705 5 significant significant JJ cord-015021-pol2qm74 6705 6 improvement improvement NN cord-015021-pol2qm74 6705 7 with with IN cord-015021-pol2qm74 6705 8 regardto regardto NN cord-015021-pol2qm74 6705 9 mortality mortality NN cord-015021-pol2qm74 6705 10 in in IN cord-015021-pol2qm74 6705 11 those those DT cord-015021-pol2qm74 6705 12 patients patient NNS cord-015021-pol2qm74 6705 13 receiving receive VBG cord-015021-pol2qm74 6705 14 the the DT cord-015021-pol2qm74 6705 15 highest high JJS cord-015021-pol2qm74 6705 16 tirilazad tirilazad NNP cord-015021-pol2qm74 6705 17 dose dose NN cord-015021-pol2qm74 6705 18 as as IN cord-015021-pol2qm74 6705 19 compared compare VBN cord-015021-pol2qm74 6705 20 to to IN cord-015021-pol2qm74 6705 21 placebo placebo NN cord-015021-pol2qm74 6705 22 and and CC cord-015021-pol2qm74 6705 23 the the DT cord-015021-pol2qm74 6705 24 two two CD cord-015021-pol2qm74 6705 25 lower low JJR cord-015021-pol2qm74 6705 26 dose dose NN cord-015021-pol2qm74 6705 27 groups group NNS cord-015021-pol2qm74 6705 28 . . . cord-015021-pol2qm74 6706 1 Additional additional JJ cord-015021-pol2qm74 6706 2 beneficial beneficial JJ cord-015021-pol2qm74 6706 3 effects effect NNS cord-015021-pol2qm74 6706 4 were be VBD cord-015021-pol2qm74 6706 5 seen see VBN cord-015021-pol2qm74 6706 6 in in IN cord-015021-pol2qm74 6706 7 the the DT cord-015021-pol2qm74 6706 8 6 6 CD cord-015021-pol2qm74 6706 9 rag rag NN cord-015021-pol2qm74 6706 10 / / SYM cord-015021-pol2qm74 6706 11 day day NN cord-015021-pol2qm74 6706 12 groups group NNS cord-015021-pol2qm74 6706 13 with with IN cord-015021-pol2qm74 6706 14 regard regard NN cord-015021-pol2qm74 6706 15 to to IN cord-015021-pol2qm74 6706 16 the the DT cord-015021-pol2qm74 6706 17 occurence occurence NN cord-015021-pol2qm74 6706 18 of of IN cord-015021-pol2qm74 6706 19 symptomatic symptomatic JJ cord-015021-pol2qm74 6706 20 vasospasm vasospasm NN cord-015021-pol2qm74 6706 21 and and CC cord-015021-pol2qm74 6706 22 good good JJ cord-015021-pol2qm74 6706 23 clinical clinical JJ cord-015021-pol2qm74 6706 24 outcome outcome NN cord-015021-pol2qm74 6706 25 . . . cord-015021-pol2qm74 6707 1 Although although IN cord-015021-pol2qm74 6707 2 the the DT cord-015021-pol2qm74 6707 3 final final JJ cord-015021-pol2qm74 6707 4 analysis analysis NN cord-015021-pol2qm74 6707 5 of of IN cord-015021-pol2qm74 6707 6 all all DT cord-015021-pol2qm74 6707 7 data datum NNS cord-015021-pol2qm74 6707 8 is be VBZ cord-015021-pol2qm74 6707 9 still still RB cord-015021-pol2qm74 6707 10 pending pende VBG cord-015021-pol2qm74 6707 11 , , , cord-015021-pol2qm74 6707 12 these these DT cord-015021-pol2qm74 6707 13 results result NNS cord-015021-pol2qm74 6707 14 suggest suggest VBP cord-015021-pol2qm74 6707 15 that that IN cord-015021-pol2qm74 6707 16 tirilazad tirilazad NNP cord-015021-pol2qm74 6707 17 - - HYPH cord-015021-pol2qm74 6707 18 mesylate mesylate NNP cord-015021-pol2qm74 6707 19 could could MD cord-015021-pol2qm74 6707 20 represent represent VB cord-015021-pol2qm74 6707 21 a a DT cord-015021-pol2qm74 6707 22 major major JJ cord-015021-pol2qm74 6707 23 improvement improvement NN cord-015021-pol2qm74 6707 24 for for IN cord-015021-pol2qm74 6707 25 the the DT cord-015021-pol2qm74 6707 26 treatment treatment NN cord-015021-pol2qm74 6707 27 of of IN cord-015021-pol2qm74 6707 28 patients patient NNS cord-015021-pol2qm74 6707 29 with with IN cord-015021-pol2qm74 6707 30 SAIl sail NN cord-015021-pol2qm74 6707 31 . . . cord-015021-pol2qm74 6708 1 Experimentally experimentally RB cord-015021-pol2qm74 6708 2 lipidperoxidation lipidperoxidation NN cord-015021-pol2qm74 6708 3 products product NNS cord-015021-pol2qm74 6708 4 ( ( -LRB- cord-015021-pol2qm74 6708 5 LPO LPO NNP cord-015021-pol2qm74 6708 6 ) ) -RRB- cord-015021-pol2qm74 6708 7 are be VBP cord-015021-pol2qm74 6708 8 increased increase VBN cord-015021-pol2qm74 6708 9 in in IN cord-015021-pol2qm74 6708 10 acute acute JJ cord-015021-pol2qm74 6708 11 pancreatitis pancreatitis NN cord-015021-pol2qm74 6708 12 ( ( -LRB- cord-015021-pol2qm74 6708 13 AP AP NNP cord-015021-pol2qm74 6708 14 ) ) -RRB- cord-015021-pol2qm74 6708 15 due due IN cord-015021-pol2qm74 6708 16 to to IN cord-015021-pol2qm74 6708 17 oxygen oxygen NN cord-015021-pol2qm74 6708 18 radicals radical NNS cord-015021-pol2qm74 6708 19 ( ( -LRB- cord-015021-pol2qm74 6708 20 OR or CC cord-015021-pol2qm74 6708 21 ) ) -RRB- cord-015021-pol2qm74 6708 22 . . . cord-015021-pol2qm74 6709 1 The the DT cord-015021-pol2qm74 6709 2 purpose purpose NN cord-015021-pol2qm74 6709 3 of of IN cord-015021-pol2qm74 6709 4 this this DT cord-015021-pol2qm74 6709 5 clinical clinical JJ cord-015021-pol2qm74 6709 6 study study NN cord-015021-pol2qm74 6709 7 was be VBD cord-015021-pol2qm74 6709 8 to to TO cord-015021-pol2qm74 6709 9 determine determine VB cord-015021-pol2qm74 6709 10 the the DT cord-015021-pol2qm74 6709 11 antioxidant antioxidant JJ cord-015021-pol2qm74 6709 12 status status NN cord-015021-pol2qm74 6709 13 and and CC cord-015021-pol2qm74 6709 14 LPO LPO NNP cord-015021-pol2qm74 6709 15 in in IN cord-015021-pol2qm74 6709 16 patients patient NNS cord-015021-pol2qm74 6709 17 suffering suffer VBG cord-015021-pol2qm74 6709 18 from from IN cord-015021-pol2qm74 6709 19 AP AP NNP cord-015021-pol2qm74 6709 20 and and CC cord-015021-pol2qm74 6709 21 tO to TO cord-015021-pol2qm74 6709 22 evaluate evaluate VB cord-015021-pol2qm74 6709 23 the the DT cord-015021-pol2qm74 6709 24 effect effect NN cord-015021-pol2qm74 6709 25 of of IN cord-015021-pol2qm74 6709 26 antioxidant antioxidant JJ cord-015021-pol2qm74 6709 27 treatment treatment NN cord-015021-pol2qm74 6709 28 with with IN cord-015021-pol2qm74 6709 29 sodium sodium NN cord-015021-pol2qm74 6709 30 selenite selenite NN cord-015021-pol2qm74 6709 31 ( ( -LRB- cord-015021-pol2qm74 6709 32 SE SE NNP cord-015021-pol2qm74 6709 33 ) ) -RRB- cord-015021-pol2qm74 6709 34 thus thus RB cord-015021-pol2qm74 6709 35 improving improve VBG cord-015021-pol2qm74 6709 36 the the DT cord-015021-pol2qm74 6709 37 function function NN cord-015021-pol2qm74 6709 38 of of IN cord-015021-pol2qm74 6709 39 the the DT cord-015021-pol2qm74 6709 40 SE SE NNP cord-015021-pol2qm74 6709 41 dependant dependant JJ cord-015021-pol2qm74 6709 42 glutathione glutathione NN cord-015021-pol2qm74 6709 43 peroxidase peroxidase NN cord-015021-pol2qm74 6709 44 which which WDT cord-015021-pol2qm74 6709 45 is be VBZ cord-015021-pol2qm74 6709 46 the the DT cord-015021-pol2qm74 6709 47 major major JJ cord-015021-pol2qm74 6709 48 detoxifying detoxify VBG cord-015021-pol2qm74 6709 49 system system NN cord-015021-pol2qm74 6709 50 for for IN cord-015021-pol2qm74 6709 51 OR OR NNP cord-015021-pol2qm74 6709 52 . . . cord-015021-pol2qm74 6710 1 Materials material NNS cord-015021-pol2qm74 6710 2 and and CC cord-015021-pol2qm74 6710 3 Methods method NNS cord-015021-pol2qm74 6710 4 : : : cord-015021-pol2qm74 6711 1 In in IN cord-015021-pol2qm74 6711 2 Z0 Z0 NNP cord-015021-pol2qm74 6711 3 patients patient NNS cord-015021-pol2qm74 6711 4 sufferin sufferin NNP cord-015021-pol2qm74 6711 5 s s NNP cord-015021-pol2qm74 6711 6 from from IN cord-015021-pol2qm74 6711 7 severe severe JJ cord-015021-pol2qm74 6711 8 AP AP NNP cord-015021-pol2qm74 6711 9 ( ( -LRB- cord-015021-pol2qm74 6711 10 C C NNP cord-015021-pol2qm74 6711 11 - - HYPH cord-015021-pol2qm74 6711 12 reactlve reactlve NN cord-015021-pol2qm74 6711 13 protein protein NN cord-015021-pol2qm74 6712 1 > > XX cord-015021-pol2qm74 6713 1 120 120 CD cord-015021-pol2qm74 6713 2 mE mE NNP cord-015021-pol2qm74 6713 3 / / SYM cord-015021-pol2qm74 6713 4 l l NN cord-015021-pol2qm74 6713 5 ) ) -RRB- cord-015021-pol2qm74 6714 1 we -PRON- PRP cord-015021-pol2qm74 6714 2 determined determine VBD cord-015021-pol2qm74 6714 3 on on IN cord-015021-pol2qm74 6714 4 day day NN cord-015021-pol2qm74 6714 5 1 1 CD cord-015021-pol2qm74 6714 6 and and CC cord-015021-pol2qm74 6714 7 day day NN cord-015021-pol2qm74 6714 8 8 8 CD cord-015021-pol2qm74 6714 9 after after IN cord-015021-pol2qm74 6714 10 admission admission NN cord-015021-pol2qm74 6715 1 the the DT cord-015021-pol2qm74 6715 2 LPO LPO NNP cord-015021-pol2qm74 6715 3 ma!ondialdehyd ma!ondialdehyd IN cord-015021-pol2qm74 6715 4 ( ( -LRB- cord-015021-pol2qm74 6715 5 MDA MDA NNP cord-015021-pol2qm74 6715 6 ) ) -RRB- cord-015021-pol2qm74 6715 7 , , , cord-015021-pol2qm74 6715 8 conjugated conjugate VBN cord-015021-pol2qm74 6715 9 dishes dish NNS cord-015021-pol2qm74 6715 10 ( ( -LRB- cord-015021-pol2qm74 6715 11 CD CD NNP cord-015021-pol2qm74 6715 12 ) ) -RRB- cord-015021-pol2qm74 6715 13 , , , cord-015021-pol2qm74 6715 14 reduced reduce VBN cord-015021-pol2qm74 6715 15 ( ( -LRB- cord-015021-pol2qm74 6715 16 GSR GSR NNP cord-015021-pol2qm74 6715 17 ) ) -RRB- cord-015021-pol2qm74 6715 18 and and CC cord-015021-pol2qm74 6715 19 oxidized oxidize VBN cord-015021-pol2qm74 6715 20 ( ( -LRB- cord-015021-pol2qm74 6716 1 GSSG GSSG NNP cord-015021-pol2qm74 6716 2 ) ) -RRB- cord-015021-pol2qm74 6716 3 glutathione glutathione NN cord-015021-pol2qm74 6716 4 , , , cord-015021-pol2qm74 6716 5 the the DT cord-015021-pol2qm74 6716 6 vitamins vitamin NNS cord-015021-pol2qm74 6716 7 A A NNP cord-015021-pol2qm74 6716 8 , , , cord-015021-pol2qm74 6716 9 C C NNP cord-015021-pol2qm74 6716 10 , , , cord-015021-pol2qm74 6716 11 E E NNP cord-015021-pol2qm74 6716 12 and and CC cord-015021-pol2qm74 6716 13 SE SE NNP cord-015021-pol2qm74 6716 14 . . . cord-015021-pol2qm74 6717 1 Moreover moreover RB cord-015021-pol2qm74 6717 2 the the DT cord-015021-pol2qm74 6717 3 patients patient NNS cord-015021-pol2qm74 6717 4 were be VBD cord-015021-pol2qm74 6717 5 evaluated evaluate VBN cord-015021-pol2qm74 6717 6 clinically clinically RB cord-015021-pol2qm74 6717 7 using use VBG cord-015021-pol2qm74 6717 8 the the DT cord-015021-pol2qm74 6717 9 RANSON RANSON NNP cord-015021-pol2qm74 6717 10 and and CC cord-015021-pol2qm74 6717 11 the the DT cord-015021-pol2qm74 6717 12 APACHE APACHE NNP cord-015021-pol2qm74 6717 13 II II NNP cord-015021-pol2qm74 6717 14 score score NN cord-015021-pol2qm74 6717 15 . . . cord-015021-pol2qm74 6718 1 I0 i0 NN cord-015021-pol2qm74 6718 2 patients patient NNS cord-015021-pol2qm74 6718 3 were be VBD cord-015021-pol2qm74 6718 4 randomly randomly RB cord-015021-pol2qm74 6718 5 treated treat VBN cord-015021-pol2qm74 6718 6 with with IN cord-015021-pol2qm74 6718 7 600 600 CD cord-015021-pol2qm74 6718 8 ug ug NNP cord-015021-pol2qm74 6718 9 / / SYM cord-015021-pol2qm74 6718 10 day day NN cord-015021-pol2qm74 6718 11 of of IN cord-015021-pol2qm74 6718 12 SE SE NNP cord-015021-pol2qm74 6718 13 for for IN cord-015021-pol2qm74 6718 14 8 8 CD cord-015021-pol2qm74 6718 15 days day NNS cord-015021-pol2qm74 6718 16 . . . cord-015021-pol2qm74 6719 1 Results result NNS cord-015021-pol2qm74 6719 2 : : : cord-015021-pol2qm74 6720 1 All all DT cord-015021-pol2qm74 6720 2 patients patient NNS cord-015021-pol2qm74 6720 3 suffered suffer VBD cord-015021-pol2qm74 6720 4 from from IN cord-015021-pol2qm74 6720 5 a a DT cord-015021-pol2qm74 6720 6 severe severe JJ cord-015021-pol2qm74 6720 7 depletion depletion NN cord-015021-pol2qm74 6720 8 of of IN cord-015021-pol2qm74 6720 9 antioxidants antioxidant NNS cord-015021-pol2qm74 6720 10 , , , cord-015021-pol2qm74 6720 11 especially especially RB cord-015021-pol2qm74 6720 12 a a DT cord-015021-pol2qm74 6720 13 low low JJ cord-015021-pol2qm74 6720 14 concentration concentration NN cord-015021-pol2qm74 6720 15 of of IN cord-015021-pol2qm74 6720 16 SE SE NNP cord-015021-pol2qm74 6720 17 ( ( -LRB- cord-015021-pol2qm74 6720 18 only only RB cord-015021-pol2qm74 6720 19 1/3 1/3 CD cord-015021-pol2qm74 6720 20 of of IN cord-015021-pol2qm74 6720 21 normal normal JJ cord-015021-pol2qm74 6720 22 ) ) -RRB- cord-015021-pol2qm74 6720 23 . . . cord-015021-pol2qm74 6721 1 Thereby thereby RB cord-015021-pol2qm74 6721 2 the the DT cord-015021-pol2qm74 6721 3 increase increase NN cord-015021-pol2qm74 6721 4 in in IN cord-015021-pol2qm74 6721 5 LPO LPO NNP cord-015021-pol2qm74 6721 6 correlated correlate VBD cord-015021-pol2qm74 6721 7 with with IN cord-015021-pol2qm74 6721 8 the the DT cord-015021-pol2qm74 6721 9 clinical clinical JJ cord-015021-pol2qm74 6721 10 course course NN cord-015021-pol2qm74 6721 11 . . . cord-015021-pol2qm74 6722 1 During during IN cord-015021-pol2qm74 6722 2 SE SE NNP cord-015021-pol2qm74 6722 3 treatment treatment NN cord-015021-pol2qm74 6722 4 LPO LPO NNP cord-015021-pol2qm74 6722 5 decreased decrease VBD cord-015021-pol2qm74 6722 6 and and CC cord-015021-pol2qm74 6722 7 the the DT cord-015021-pol2qm74 6722 8 levels level NNS cord-015021-pol2qm74 6722 9 of of IN cord-015021-pol2qm74 6722 10 antioxidant antioxidant JJ cord-015021-pol2qm74 6722 11 vitamins vitamin NNS cord-015021-pol2qm74 6722 12 improved improve VBD cord-015021-pol2qm74 6722 13 . . . cord-015021-pol2qm74 6723 1 SE SE NNP cord-015021-pol2qm74 6723 2 had have VBD cord-015021-pol2qm74 6723 3 no no DT cord-015021-pol2qm74 6723 4 influence influence NN cord-015021-pol2qm74 6723 5 on on IN cord-015021-pol2qm74 6723 6 leth leth NN cord-015021-pol2qm74 6723 7 - - HYPH cord-015021-pol2qm74 6723 8 slity slity NN cord-015021-pol2qm74 6723 9 the the DT cord-015021-pol2qm74 6723 10 lenl lenl NNP cord-015021-pol2qm74 6723 11 or or CC cord-015021-pol2qm74 6723 12 the the DT cord-015021-pol2qm74 6723 13 chan chan NNP cord-015021-pol2qm74 6723 14 in in IN cord-015021-pol2qm74 6723 15 RS RS NNP cord-015021-pol2qm74 6723 16 or or CC cord-015021-pol2qm74 6723 17 AP AP NNP cord-015021-pol2qm74 6723 18 II II NNP cord-015021-pol2qm74 6723 19 . . . cord-015021-pol2qm74 6724 1 Background background NN cord-015021-pol2qm74 6724 2 : : : cord-015021-pol2qm74 6725 1 Since since IN cord-015021-pol2qm74 6725 2 reperfusion reperfusion NN cord-015021-pol2qm74 6725 3 injury injury NN cord-015021-pol2qm74 6725 4 occurs occur VBZ cord-015021-pol2qm74 6725 5 when when WRB cord-015021-pol2qm74 6725 6 oxygen oxygen NN cord-015021-pol2qm74 6725 7 is be VBZ cord-015021-pol2qm74 6725 8 reintroduced reintroduce VBN cord-015021-pol2qm74 6725 9 into into IN cord-015021-pol2qm74 6725 10 ischemic ischemic JJ cord-015021-pol2qm74 6725 11 tissue tissue NN cord-015021-pol2qm74 6725 12 , , , cord-015021-pol2qm74 6725 13 the the DT cord-015021-pol2qm74 6725 14 ideal ideal JJ cord-015021-pol2qm74 6725 15 timing timing NN cord-015021-pol2qm74 6725 16 for for IN cord-015021-pol2qm74 6725 17 administration administration NN cord-015021-pol2qm74 6725 18 of of IN cord-015021-pol2qm74 6725 19 therapeutic therapeutic JJ cord-015021-pol2qm74 6725 20 compounds compound NNS cord-015021-pol2qm74 6725 21 aimed aim VBN cord-015021-pol2qm74 6725 22 at at IN cord-015021-pol2qm74 6725 23 ameliorating ameliorate VBG cord-015021-pol2qm74 6725 24 oxygen oxygen NN cord-015021-pol2qm74 6725 25 radical radical JJ cord-015021-pol2qm74 6725 26 mediated mediate VBN cord-015021-pol2qm74 6725 27 injury injury NN cord-015021-pol2qm74 6725 28 is be VBZ cord-015021-pol2qm74 6725 29 at at IN cord-015021-pol2qm74 6725 30 the the DT cord-015021-pol2qm74 6725 31 time time NN cord-015021-pol2qm74 6725 32 of of IN cord-015021-pol2qm74 6725 33 initial initial JJ cord-015021-pol2qm74 6725 34 fluid fluid JJ cord-015021-pol2qm74 6725 35 resuscitation resuscitation NN cord-015021-pol2qm74 6725 36 . . . cord-015021-pol2qm74 6726 1 Currently currently RB cord-015021-pol2qm74 6726 2 used use VBN cord-015021-pol2qm74 6726 3 colloid colloid NN cord-015021-pol2qm74 6726 4 or or CC cord-015021-pol2qm74 6726 5 crystalloid crystalloid NN cord-015021-pol2qm74 6726 6 preparations preparation NNS cord-015021-pol2qm74 6726 7 do do VBP cord-015021-pol2qm74 6726 8 not not RB cord-015021-pol2qm74 6726 9 provide provide VB cord-015021-pol2qm74 6726 10 optimal optimal JJ cord-015021-pol2qm74 6726 11 , , , cord-015021-pol2qm74 6726 12 or or CC cord-015021-pol2qm74 6726 13 even even RB cord-015021-pol2qm74 6726 14 significant significant JJ cord-015021-pol2qm74 6726 15 , , , cord-015021-pol2qm74 6726 16 anti anti JJ cord-015021-pol2qm74 6726 17 - - JJ cord-015021-pol2qm74 6726 18 oxidant oxidant JJ cord-015021-pol2qm74 6726 19 protection protection NN cord-015021-pol2qm74 6726 20 . . . cord-015021-pol2qm74 6727 1 Systemic systemic JJ cord-015021-pol2qm74 6727 2 iron iron NN cord-015021-pol2qm74 6727 3 chelation chelation NN cord-015021-pol2qm74 6727 4 affords afford VBZ cord-015021-pol2qm74 6727 5 protection protection NN cord-015021-pol2qm74 6727 6 against against IN cord-015021-pol2qm74 6727 7 the the DT cord-015021-pol2qm74 6727 8 iron iron NN cord-015021-pol2qm74 6727 9 catalyzed catalyze VBN cord-015021-pol2qm74 6727 10 components component NNS cord-015021-pol2qm74 6727 11 of of IN cord-015021-pol2qm74 6727 12 oxygen oxygen NN cord-015021-pol2qm74 6727 13 and and CC cord-015021-pol2qm74 6727 14 lipid lipid NN cord-015021-pol2qm74 6727 15 radical radical JJ cord-015021-pol2qm74 6727 16 mediated mediate VBN cord-015021-pol2qm74 6727 17 tissue tissue NN cord-015021-pol2qm74 6727 18 injury injury NN cord-015021-pol2qm74 6727 19 . . . cord-015021-pol2qm74 6728 1 The the DT cord-015021-pol2qm74 6728 2 conjugate conjugate NN cord-015021-pol2qm74 6728 3 resulting result VBG cord-015021-pol2qm74 6728 4 from from IN cord-015021-pol2qm74 6728 5 chemical chemical JJ cord-015021-pol2qm74 6728 6 attachment attachment NN cord-015021-pol2qm74 6728 7 of of IN cord-015021-pol2qm74 6728 8 the the DT cord-015021-pol2qm74 6728 9 clinically clinically RB cord-015021-pol2qm74 6728 10 approved approve VBN cord-015021-pol2qm74 6728 11 iron iron NN cord-015021-pol2qm74 6728 12 chelator chelator NN cord-015021-pol2qm74 6728 13 , , , cord-015021-pol2qm74 6728 14 deferoxamine deferoxamine NNP cord-015021-pol2qm74 6728 15 ( ( -LRB- cord-015021-pol2qm74 6728 16 DFO DFO NNP cord-015021-pol2qm74 6728 17 , , , cord-015021-pol2qm74 6728 18 Desferal Desferal NNP cord-015021-pol2qm74 6728 19 ® ® NNP cord-015021-pol2qm74 6728 20 , , , cord-015021-pol2qm74 6728 21 Ciba Ciba NNP cord-015021-pol2qm74 6728 22 ) ) -RRB- cord-015021-pol2qm74 6728 23 , , , cord-015021-pol2qm74 6728 24 to to IN cord-015021-pol2qm74 6728 25 hydroxyethyl hydroxyethyl NN cord-015021-pol2qm74 6728 26 starch starch NN cord-015021-pol2qm74 6728 27 ( ( -LRB- cord-015021-pol2qm74 6728 28 HES HES NNP cord-015021-pol2qm74 6728 29 ) ) -RRB- cord-015021-pol2qm74 6728 30 represents represent VBZ cord-015021-pol2qm74 6728 31 a a DT cord-015021-pol2qm74 6728 32 novel novel JJ cord-015021-pol2qm74 6728 33 approach approach NN cord-015021-pol2qm74 6728 34 to to IN cord-015021-pol2qm74 6728 35 colloid colloid NN cord-015021-pol2qm74 6728 36 based base VBN cord-015021-pol2qm74 6728 37 fluid fluid JJ cord-015021-pol2qm74 6728 38 resuscitation resuscitation NN cord-015021-pol2qm74 6728 39 . . . cord-015021-pol2qm74 6729 1 HES HES NNP cord-015021-pol2qm74 6729 2 - - HYPH cord-015021-pol2qm74 6729 3 DFO DFO NNP cord-015021-pol2qm74 6729 4 contains contain VBZ cord-015021-pol2qm74 6729 5 85 85 CD cord-015021-pol2qm74 6729 6 % % NN cord-015021-pol2qm74 6729 7 HES hes NN cord-015021-pol2qm74 6729 8 and and CC cord-015021-pol2qm74 6730 1 15 15 CD cord-015021-pol2qm74 6730 2 % % NN cord-015021-pol2qm74 6730 3 chemically chemically RB cord-015021-pol2qm74 6730 4 bound bind VBN cord-015021-pol2qm74 6730 5 DFO DFO NNP cord-015021-pol2qm74 6730 6 . . . cord-015021-pol2qm74 6731 1 The the DT cord-015021-pol2qm74 6731 2 polymer polymer NN cord-015021-pol2qm74 6731 3 - - HYPH cord-015021-pol2qm74 6731 4 drug drug NN cord-015021-pol2qm74 6731 5 conjugate conjugate NN cord-015021-pol2qm74 6731 6 has have VBZ cord-015021-pol2qm74 6731 7 a a DT cord-015021-pol2qm74 6731 8 lower low JJR cord-015021-pol2qm74 6731 9 molecular molecular JJ cord-015021-pol2qm74 6731 10 weight weight NN cord-015021-pol2qm74 6731 11 than than IN cord-015021-pol2qm74 6731 12 that that DT cord-015021-pol2qm74 6731 13 of of IN cord-015021-pol2qm74 6731 14 HES HES NNP cord-015021-pol2qm74 6731 15 in in IN cord-015021-pol2qm74 6731 16 order order NN cord-015021-pol2qm74 6731 17 to to TO cord-015021-pol2qm74 6731 18 allow allow VB cord-015021-pol2qm74 6731 19 more more RBR cord-015021-pol2qm74 6731 20 rapid rapid JJ cord-015021-pol2qm74 6731 21 excretion excretion NN cord-015021-pol2qm74 6731 22 . . . cord-015021-pol2qm74 6732 1 Results result NNS cord-015021-pol2qm74 6732 2 : : : cord-015021-pol2qm74 6733 1 Preclinical preclinical JJ cord-015021-pol2qm74 6733 2 and and CC cord-015021-pol2qm74 6733 3 initial initial JJ cord-015021-pol2qm74 6733 4 clinical clinical JJ cord-015021-pol2qm74 6733 5 trials trial NNS cord-015021-pol2qm74 6733 6 indicate indicate VBP cord-015021-pol2qm74 6733 7 that that IN cord-015021-pol2qm74 6733 8 HES HES NNP cord-015021-pol2qm74 6733 9 - - HYPH cord-015021-pol2qm74 6733 10 DFO DFO NNP cord-015021-pol2qm74 6733 11 is be VBZ cord-015021-pol2qm74 6733 12 well well RB cord-015021-pol2qm74 6733 13 tolerated tolerate VBN cord-015021-pol2qm74 6733 14 , , , cord-015021-pol2qm74 6733 15 even even RB cord-015021-pol2qm74 6733 16 at at IN cord-015021-pol2qm74 6733 17 high high JJ cord-015021-pol2qm74 6733 18 doses dose NNS cord-015021-pol2qm74 6733 19 . . . cord-015021-pol2qm74 6734 1 In in IN cord-015021-pol2qm74 6734 2 animal animal NN cord-015021-pol2qm74 6734 3 studies study NNS cord-015021-pol2qm74 6734 4 , , , cord-015021-pol2qm74 6734 5 fluid fluid JJ cord-015021-pol2qm74 6734 6 resuscitation resuscitation NN cord-015021-pol2qm74 6734 7 with with IN cord-015021-pol2qm74 6734 8 HES HES NNP cord-015021-pol2qm74 6734 9 - - HYPH cord-015021-pol2qm74 6734 10 DFO DFO NNP cord-015021-pol2qm74 6734 11 does do VBZ cord-015021-pol2qm74 6734 12 not not RB cord-015021-pol2qm74 6734 13 significantly significantly RB cord-015021-pol2qm74 6734 14 improve improve VB cord-015021-pol2qm74 6734 15 central central JJ cord-015021-pol2qm74 6734 16 hemodynamic hemodynamic JJ cord-015021-pol2qm74 6734 17 recovery recovery NN cord-015021-pol2qm74 6734 18 beyond beyond IN cord-015021-pol2qm74 6734 19 that that DT cord-015021-pol2qm74 6734 20 observed observe VBD cord-015021-pol2qm74 6734 21 with with IN cord-015021-pol2qm74 6734 22 HES HES NNP cord-015021-pol2qm74 6734 23 , , , cord-015021-pol2qm74 6734 24 but but CC cord-015021-pol2qm74 6734 25 HES HES NNP cord-015021-pol2qm74 6734 26 - - HYPH cord-015021-pol2qm74 6734 27 DFO DFO NNP cord-015021-pol2qm74 6734 28 seems seem VBZ cord-015021-pol2qm74 6734 29 to to TO cord-015021-pol2qm74 6734 30 afford afford VB cord-015021-pol2qm74 6734 31 better well JJR cord-015021-pol2qm74 6734 32 protection protection NN cord-015021-pol2qm74 6734 33 of of IN cord-015021-pol2qm74 6734 34 microcirculation microcirculation NN cord-015021-pol2qm74 6734 35 in in IN cord-015021-pol2qm74 6734 36 organs organ NNS cord-015021-pol2qm74 6734 37 at at IN cord-015021-pol2qm74 6734 38 risk risk NN cord-015021-pol2qm74 6734 39 ( ( -LRB- cord-015021-pol2qm74 6734 40 lung lung NN cord-015021-pol2qm74 6734 41 , , , cord-015021-pol2qm74 6734 42 liver liver NN cord-015021-pol2qm74 6734 43 and and CC cord-015021-pol2qm74 6734 44 gut gut NN cord-015021-pol2qm74 6734 45 ) ) -RRB- cord-015021-pol2qm74 6734 46 , , , cord-015021-pol2qm74 6734 47 possibly possibly RB cord-015021-pol2qm74 6734 48 by by IN cord-015021-pol2qm74 6734 49 decreasing decrease VBG cord-015021-pol2qm74 6734 50 neutrophil neutrophil NN cord-015021-pol2qm74 6734 51 sequestration sequestration NN cord-015021-pol2qm74 6734 52 . . . cord-015021-pol2qm74 6735 1 In in IN cord-015021-pol2qm74 6735 2 a a DT cord-015021-pol2qm74 6735 3 burn burn NN cord-015021-pol2qm74 6735 4 model model NN cord-015021-pol2qm74 6735 5 , , , cord-015021-pol2qm74 6735 6 total total JJ cord-015021-pol2qm74 6735 7 fluid fluid JJ cord-015021-pol2qm74 6735 8 requirements requirement NNS cord-015021-pol2qm74 6735 9 are be VBP cord-015021-pol2qm74 6735 10 lower low JJR cord-015021-pol2qm74 6735 11 and and CC cord-015021-pol2qm74 6735 12 oxygen oxygen NN cord-015021-pol2qm74 6735 13 utilization utilization NN cord-015021-pol2qm74 6735 14 higher high JJR cord-015021-pol2qm74 6735 15 in in IN cord-015021-pol2qm74 6735 16 HES HES NNP cord-015021-pol2qm74 6735 17 - - HYPH cord-015021-pol2qm74 6735 18 DFO DFO NNP cord-015021-pol2qm74 6736 1 treated treat VBN cord-015021-pol2qm74 6736 2 animals animal NNS cord-015021-pol2qm74 6736 3 compared compare VBN cord-015021-pol2qm74 6736 4 to to IN cord-015021-pol2qm74 6736 5 HES HES NNP cord-015021-pol2qm74 6736 6 controls control NNS cord-015021-pol2qm74 6736 7 , , , cord-015021-pol2qm74 6736 8 suggesting suggest VBG cord-015021-pol2qm74 6736 9 decreased decrease VBD cord-015021-pol2qm74 6736 10 vascular vascular JJ cord-015021-pol2qm74 6736 11 leak leak NN cord-015021-pol2qm74 6736 12 and and CC cord-015021-pol2qm74 6736 13 improved improved JJ cord-015021-pol2qm74 6736 14 tissue tissue NN cord-015021-pol2qm74 6736 15 perfusion perfusion NN cord-015021-pol2qm74 6736 16 . . . cord-015021-pol2qm74 6737 1 Conclusion conclusion NN cord-015021-pol2qm74 6737 2 : : : cord-015021-pol2qm74 6738 1 HES HES NNP cord-015021-pol2qm74 6738 2 - - HYPH cord-015021-pol2qm74 6738 3 DFO DFO NNP cord-015021-pol2qm74 6738 4 represents represent VBZ cord-015021-pol2qm74 6738 5 a a DT cord-015021-pol2qm74 6738 6 means means NN cord-015021-pol2qm74 6738 7 by by IN cord-015021-pol2qm74 6738 8 which which WDT cord-015021-pol2qm74 6738 9 potent potent JJ cord-015021-pol2qm74 6738 10 antioxidant antioxidant NN cord-015021-pol2qm74 6738 11 protection protection NN cord-015021-pol2qm74 6738 12 can can MD cord-015021-pol2qm74 6738 13 be be VB cord-015021-pol2qm74 6738 14 administered administer VBN cord-015021-pol2qm74 6738 15 at at IN cord-015021-pol2qm74 6738 16 resuscitation resuscitation NN cord-015021-pol2qm74 6738 17 . . . cord-015021-pol2qm74 6739 1 Iron iron NN cord-015021-pol2qm74 6739 2 has have VBZ cord-015021-pol2qm74 6739 3 been be VBN cord-015021-pol2qm74 6739 4 suggested suggest VBN cord-015021-pol2qm74 6739 5 to to TO cord-015021-pol2qm74 6739 6 play play VB cord-015021-pol2qm74 6739 7 a a DT cord-015021-pol2qm74 6739 8 pivotal pivotal JJ cord-015021-pol2qm74 6739 9 role role NN cord-015021-pol2qm74 6739 10 in in IN cord-015021-pol2qm74 6739 11 oxygen oxygen NN cord-015021-pol2qm74 6739 12 flee flee NN cord-015021-pol2qm74 6739 13 radical radical JJ cord-015021-pol2qm74 6739 14 mediated mediate VBN cord-015021-pol2qm74 6739 15 tissue tissue NN cord-015021-pol2qm74 6739 16 injury injury NN cord-015021-pol2qm74 6739 17 . . . cord-015021-pol2qm74 6740 1 In in IN cord-015021-pol2qm74 6740 2 vitro vitro FW cord-015021-pol2qm74 6740 3 experiments experiment NNS cord-015021-pol2qm74 6740 4 indicated indicate VBD cord-015021-pol2qm74 6740 5 its -PRON- PRP$ cord-015021-pol2qm74 6740 6 critical critical JJ cord-015021-pol2qm74 6740 7 role role NN cord-015021-pol2qm74 6740 8 as as IN cord-015021-pol2qm74 6740 9 a a DT cord-015021-pol2qm74 6740 10 katalyst katalyst NN cord-015021-pol2qm74 6740 11 in in IN cord-015021-pol2qm74 6740 12 hydroxyl hydroxyl NN cord-015021-pol2qm74 6740 13 free free JJ cord-015021-pol2qm74 6740 14 radical radical JJ cord-015021-pol2qm74 6740 15 generation generation NN cord-015021-pol2qm74 6740 16 0Fenton 0fenton JJ cord-015021-pol2qm74 6740 17 - - HYPH cord-015021-pol2qm74 6740 18 reaction reaction NN cord-015021-pol2qm74 6740 19 ) ) -RRB- cord-015021-pol2qm74 6740 20 . . . cord-015021-pol2qm74 6741 1 Since since IN cord-015021-pol2qm74 6741 2 iron iron NN cord-015021-pol2qm74 6741 3 chelator chelator NN cord-015021-pol2qm74 6741 4 deferoxamine deferoxamine NN cord-015021-pol2qm74 6741 5 administered administer VBN cord-015021-pol2qm74 6741 6 in in IN cord-015021-pol2qm74 6741 7 shock shock NN cord-015021-pol2qm74 6741 8 alone alone RB cord-015021-pol2qm74 6741 9 demonstrated demonstrate VBD cord-015021-pol2qm74 6741 10 severe severe JJ cord-015021-pol2qm74 6741 11 side side NN cord-015021-pol2qm74 6741 12 effects effect NNS cord-015021-pol2qm74 6741 13 , , , cord-015021-pol2qm74 6741 14 a a DT cord-015021-pol2qm74 6741 15 hydroxyethylstarch hydroxyethylstarch NN cord-015021-pol2qm74 6741 16 ( ( -LRB- cord-015021-pol2qm74 6741 17 HES)daferoxamine HES)daferoxamine NNP cord-015021-pol2qm74 6741 18 ( ( -LRB- cord-015021-pol2qm74 6741 19 DFO)-conjugute DFO)-conjugute NNP cord-015021-pol2qm74 6741 20 was be VBD cord-015021-pol2qm74 6741 21 used use VBN cord-015021-pol2qm74 6741 22 to to TO cord-015021-pol2qm74 6741 23 modulate modulate VB cord-015021-pol2qm74 6741 24 oxygen oxygen NN cord-015021-pol2qm74 6741 25 free free JJ cord-015021-pol2qm74 6741 26 radical radical JJ cord-015021-pol2qm74 6741 27 injury injury NN cord-015021-pol2qm74 6741 28 during during IN cord-015021-pol2qm74 6741 29 the the DT cord-015021-pol2qm74 6741 30 ischemia ischemia NN cord-015021-pol2qm74 6741 31 / / SYM cord-015021-pol2qm74 6741 32 reperfi reperfi NNP cord-015021-pol2qm74 6741 33 ~ ~ NFP cord-015021-pol2qm74 6741 34 ion ion NN cord-015021-pol2qm74 6741 35 syndrome syndrome NN cord-015021-pol2qm74 6741 36 induced induce VBN cord-015021-pol2qm74 6741 37 by by IN cord-015021-pol2qm74 6741 38 hemorrhagic hemorrhagic JJ cord-015021-pol2qm74 6741 39 shock shock NN cord-015021-pol2qm74 6741 40 . . . cord-015021-pol2qm74 6742 1 Methods method NNS cord-015021-pol2qm74 6742 2 . . . cord-015021-pol2qm74 6743 1 Female Female NNP cord-015021-pol2qm74 6743 2 LEWIS LEWIS NNP cord-015021-pol2qm74 6743 3 rats rat NNS cord-015021-pol2qm74 6743 4 ( ( -LRB- cord-015021-pol2qm74 6743 5 190 190 CD cord-015021-pol2qm74 6743 6 - - SYM cord-015021-pol2qm74 6743 7 215 215 CD cord-015021-pol2qm74 6743 8 g g NN cord-015021-pol2qm74 6743 9 , , , cord-015021-pol2qm74 6743 10 n>6 n>6 NNP cord-015021-pol2qm74 6743 11 ; ; , cord-015021-pol2qm74 6743 12 pentobarbital pentobarbital NN cord-015021-pol2qm74 6743 13 anesthesia anesthesia NN cord-015021-pol2qm74 6743 14 50 50 CD cord-015021-pol2qm74 6743 15 mgjkg mgjkg NN cord-015021-pol2qm74 6743 16 ) ) -RRB- cord-015021-pol2qm74 6743 17 , , , cord-015021-pol2qm74 6743 18 in in IN cord-015021-pol2qm74 6743 19 hemorrhagic hemorrhagic JJ cord-015021-pol2qm74 6743 20 shock shock NN cord-015021-pol2qm74 6743 21 ( ( -LRB- cord-015021-pol2qm74 6743 22 The the DT cord-015021-pol2qm74 6743 23 aim aim NN cord-015021-pol2qm74 6743 24 of of IN cord-015021-pol2qm74 6743 25 the the DT cord-015021-pol2qm74 6743 26 study study NN cord-015021-pol2qm74 6743 27 was be VBD cord-015021-pol2qm74 6743 28 to to TO cord-015021-pol2qm74 6743 29 elucidate elucidate VB cord-015021-pol2qm74 6743 30 ( ( -LRB- cord-015021-pol2qm74 6743 31 1 1 CD cord-015021-pol2qm74 6743 32 ) ) -RRB- cord-015021-pol2qm74 6743 33 whether whether IN cord-015021-pol2qm74 6743 34 the the DT cord-015021-pol2qm74 6743 35 generation generation NN cord-015021-pol2qm74 6743 36 of of IN cord-015021-pol2qm74 6743 37 OR or CC cord-015021-pol2qm74 6743 38 would would MD cord-015021-pol2qm74 6743 39 affect affect VB cord-015021-pol2qm74 6743 40 lung lung NN cord-015021-pol2qm74 6743 41 and and CC cord-015021-pol2qm74 6743 42 kidneys kidney NNS cord-015021-pol2qm74 6743 43 as as IN cord-015021-pol2qm74 6743 44 primary primary JJ cord-015021-pol2qm74 6743 45 shock shock NN cord-015021-pol2qm74 6743 46 organs organ NNS cord-015021-pol2qm74 6743 47 in in IN cord-015021-pol2qm74 6743 48 the the DT cord-015021-pol2qm74 6743 49 very very RB cord-015021-pol2qm74 6743 50 early early JJ cord-015021-pol2qm74 6743 51 phase phase NN cord-015021-pol2qm74 6743 52 of of IN cord-015021-pol2qm74 6743 53 sepsis sepsis NN cord-015021-pol2qm74 6743 54 and and CC cord-015021-pol2qm74 6743 55 ( ( -LRB- cord-015021-pol2qm74 6743 56 2 2 LS cord-015021-pol2qm74 6743 57 ) ) -RRB- cord-015021-pol2qm74 6743 58 whether whether IN cord-015021-pol2qm74 6743 59 DFO DFO NNP cord-015021-pol2qm74 6743 60 - - HYPH cord-015021-pol2qm74 6743 61 HES HES NNP cord-015021-pol2qm74 6743 62 could could MD cord-015021-pol2qm74 6743 63 prevent prevent VB cord-015021-pol2qm74 6743 64 this this DT cord-015021-pol2qm74 6743 65 tissue tissue NN cord-015021-pol2qm74 6743 66 damage damage NN cord-015021-pol2qm74 6743 67 . . . cord-015021-pol2qm74 6744 1 Methods method NNS cord-015021-pol2qm74 6744 2 : : : cord-015021-pol2qm74 6744 3 In in IN cord-015021-pol2qm74 6744 4 67 67 CD cord-015021-pol2qm74 6744 5 rats rat NNS cord-015021-pol2qm74 6744 6 sepsis sepsis NN cord-015021-pol2qm74 6744 7 was be VBD cord-015021-pol2qm74 6744 8 induced induce VBN cord-015021-pol2qm74 6744 9 by by IN cord-015021-pol2qm74 6744 10 cecal cecal JJ cord-015021-pol2qm74 6744 11 ligation ligation NN cord-015021-pol2qm74 6744 12 puncture puncture NN cord-015021-pol2qm74 6744 13 ( ( -LRB- cord-015021-pol2qm74 6744 14 CLP CLP NNP cord-015021-pol2qm74 6744 15 ) ) -RRB- cord-015021-pol2qm74 6744 16 peritonitis peritonitis NN cord-015021-pol2qm74 6744 17 . . . cord-015021-pol2qm74 6745 1 The the DT cord-015021-pol2qm74 6745 2 animals animal NNS cord-015021-pol2qm74 6745 3 were be VBD cord-015021-pol2qm74 6745 4 randomly randomly RB cord-015021-pol2qm74 6745 5 assessed assess VBN cord-015021-pol2qm74 6745 6 to to IN cord-015021-pol2qm74 6745 7 2 2 CD cord-015021-pol2qm74 6745 8 groups group NNS cord-015021-pol2qm74 6745 9 : : : cord-015021-pol2qm74 6745 10 one one CD cord-015021-pol2qm74 6745 11 group group NN cord-015021-pol2qm74 6745 12 was be VBD cord-015021-pol2qm74 6745 13 treated treat VBN cord-015021-pol2qm74 6745 14 with with IN cord-015021-pol2qm74 6745 15 3 3 CD cord-015021-pol2qm74 6745 16 ml ml NN cord-015021-pol2qm74 6745 17 DFO DFO NNP cord-015021-pol2qm74 6745 18 - - HYPH cord-015021-pol2qm74 6745 19 HES HES NNP cord-015021-pol2qm74 6746 1 ( ( -LRB- cord-015021-pol2qm74 6746 2 100 100 CD cord-015021-pol2qm74 6746 3 mg mg NNP cord-015021-pol2qm74 6746 4 / / SYM cord-015021-pol2qm74 6746 5 kg kg NNP cord-015021-pol2qm74 6746 6 iv iv CD cord-015021-pol2qm74 6746 7 ) ) -RRB- cord-015021-pol2qm74 6746 8 , , , cord-015021-pol2qm74 6746 9 the the DT cord-015021-pol2qm74 6746 10 other other JJ cord-015021-pol2qm74 6746 11 rats rat NNS cord-015021-pol2qm74 6746 12 received receive VBD cord-015021-pol2qm74 6746 13 solely solely RB cord-015021-pol2qm74 6746 14 3 3 CD cord-015021-pol2qm74 6746 15 ml ml NNS cord-015021-pol2qm74 6746 16 of of IN cord-015021-pol2qm74 6746 17 the the DT cord-015021-pol2qm74 6746 18 carrier carrier NN cord-015021-pol2qm74 6746 19 starch starch NN cord-015021-pol2qm74 6746 20 solution solution NN cord-015021-pol2qm74 6746 21 . . . cord-015021-pol2qm74 6747 1 30 30 CD cord-015021-pol2qm74 6747 2 , , , cord-015021-pol2qm74 6747 3 60 60 CD cord-015021-pol2qm74 6747 4 , , , cord-015021-pol2qm74 6747 5 120 120 CD cord-015021-pol2qm74 6747 6 , , , cord-015021-pol2qm74 6747 7 and and CC cord-015021-pol2qm74 6747 8 240 240 CD cord-015021-pol2qm74 6747 9 min min NN cord-015021-pol2qm74 6747 10 after after IN cord-015021-pol2qm74 6747 11 induction induction NN cord-015021-pol2qm74 6747 12 of of IN cord-015021-pol2qm74 6747 13 sepsis sepsis NN cord-015021-pol2qm74 6748 1 respectively respectively RB cord-015021-pol2qm74 6748 2 , , , cord-015021-pol2qm74 6748 3 the the DT cord-015021-pol2qm74 6748 4 animals animal NNS cord-015021-pol2qm74 6748 5 were be VBD cord-015021-pol2qm74 6748 6 sacrificed sacrifice VBN cord-015021-pol2qm74 6748 7 , , , cord-015021-pol2qm74 6748 8 the the DT cord-015021-pol2qm74 6748 9 organs organ NNS cord-015021-pol2qm74 6748 10 collected collect VBN cord-015021-pol2qm74 6748 11 , , , cord-015021-pol2qm74 6748 12 and and CC cord-015021-pol2qm74 6748 13 tissue tissue NN cord-015021-pol2qm74 6748 14 contents content NNS cord-015021-pol2qm74 6748 15 of of IN cord-015021-pol2qm74 6748 16 glutathione glutathione NN cord-015021-pol2qm74 6748 17 ( ( -LRB- cord-015021-pol2qm74 6748 18 GSH GSH NNP cord-015021-pol2qm74 6748 19 ) ) -RRB- cord-015021-pol2qm74 6748 20 , , , cord-015021-pol2qm74 6748 21 malondialdehyde malondialdehyde NNP cord-015021-pol2qm74 6748 22 ( ( -LRB- cord-015021-pol2qm74 6748 23 MDA MDA NNP cord-015021-pol2qm74 6748 24 ) ) -RRB- cord-015021-pol2qm74 6748 25 , , , cord-015021-pol2qm74 6748 26 myeloperoxidase myeloperoxidase NNP cord-015021-pol2qm74 6748 27 ( ( -LRB- cord-015021-pol2qm74 6748 28 MPO MPO NNP cord-015021-pol2qm74 6748 29 ) ) -RRB- cord-015021-pol2qm74 6748 30 and and CC cord-015021-pol2qm74 6748 31 conjugated conjugate VBN cord-015021-pol2qm74 6748 32 dienes diene NNS cord-015021-pol2qm74 6748 33 ( ( -LRB- cord-015021-pol2qm74 6748 34 CD CD NNP cord-015021-pol2qm74 6748 35 ) ) -RRB- cord-015021-pol2qm74 6748 36 determined determine VBD cord-015021-pol2qm74 6748 37 . . . cord-015021-pol2qm74 6749 1 Plasma plasma NN cord-015021-pol2qm74 6749 2 samples sample NNS cord-015021-pol2qm74 6749 3 were be VBD cord-015021-pol2qm74 6749 4 obtained obtain VBN cord-015021-pol2qm74 6749 5 for for IN cord-015021-pol2qm74 6749 6 analyses analysis NNS cord-015021-pol2qm74 6749 7 of of IN cord-015021-pol2qm74 6749 8 endotoxin endotoxin NN cord-015021-pol2qm74 6749 9 ( ( -LRB- cord-015021-pol2qm74 6749 10 chromogenic chromogenic NNP cord-015021-pol2qm74 6749 11 LAL LAL NNP cord-015021-pol2qm74 6749 12 test test NN cord-015021-pol2qm74 6749 13 ) ) -RRB- cord-015021-pol2qm74 6749 14 . . . cord-015021-pol2qm74 6750 1 Blood blood NN cord-015021-pol2qm74 6750 2 pressure pressure NN cord-015021-pol2qm74 6750 3 ( ( -LRB- cord-015021-pol2qm74 6750 4 MAP MAP NNP cord-015021-pol2qm74 6750 5 ) ) -RRB- cord-015021-pol2qm74 6750 6 was be VBD cord-015021-pol2qm74 6750 7 measured measure VBN cord-015021-pol2qm74 6750 8 via via IN cord-015021-pol2qm74 6750 9 a a DT cord-015021-pol2qm74 6750 10 carotid carotid JJ cord-015021-pol2qm74 6750 11 artery artery NN cord-015021-pol2qm74 6750 12 catheter catheter NN cord-015021-pol2qm74 6750 13 . . . cord-015021-pol2qm74 6751 1 Results result NNS cord-015021-pol2qm74 6751 2 : : : cord-015021-pol2qm74 6752 1 CLP CLP NNP cord-015021-pol2qm74 6752 2 caused cause VBD cord-015021-pol2qm74 6752 3 sepsis sepsis NN cord-015021-pol2qm74 6752 4 with with IN cord-015021-pol2qm74 6752 5 high high JJ cord-015021-pol2qm74 6752 6 ( ( -LRB- cord-015021-pol2qm74 6752 7 > > NFP cord-015021-pol2qm74 6752 8 1.84 1.84 CD cord-015021-pol2qm74 6752 9 EU EU NNP cord-015021-pol2qm74 6752 10 / / SYM cord-015021-pol2qm74 6752 11 ml ml NN cord-015021-pol2qm74 6752 12 ) ) -RRB- cord-015021-pol2qm74 6752 13 endotoxin endotoxin NN cord-015021-pol2qm74 6752 14 levels level NNS cord-015021-pol2qm74 6752 15 . . . cord-015021-pol2qm74 6753 1 MAP map VB cord-015021-pol2qm74 6753 2 in in IN cord-015021-pol2qm74 6753 3 both both DT cord-015021-pol2qm74 6753 4 groups group NNS cord-015021-pol2qm74 6753 5 decreased decrease VBD cord-015021-pol2qm74 6753 6 slightly slightly RB cord-015021-pol2qm74 6753 7 but but CC cord-015021-pol2qm74 6753 8 significantly significantly RB cord-015021-pol2qm74 6753 9 during during IN cord-015021-pol2qm74 6753 10 sepsis sepsis NN cord-015021-pol2qm74 6753 11 regardless regardless RB cord-015021-pol2qm74 6753 12 any any DT cord-015021-pol2qm74 6753 13 treatment treatment NN cord-015021-pol2qm74 6753 14 . . . cord-015021-pol2qm74 6754 1 In in IN cord-015021-pol2qm74 6754 2 the the DT cord-015021-pol2qm74 6754 3 lungs lung NNS cord-015021-pol2qm74 6754 4 MPO MPO NNP cord-015021-pol2qm74 6754 5 concentration concentration NN cord-015021-pol2qm74 6754 6 was be VBD cord-015021-pol2qm74 6754 7 increased increase VBN cord-015021-pol2qm74 6754 8 ( ( -LRB- cord-015021-pol2qm74 6754 9 p<0.05 p<0.05 CD cord-015021-pol2qm74 6754 10 ) ) -RRB- cord-015021-pol2qm74 6754 11 in in IN cord-015021-pol2qm74 6754 12 the the DT cord-015021-pol2qm74 6754 13 lIES lIES NNP cord-015021-pol2qm74 6754 14 group group NN cord-015021-pol2qm74 6754 15 already already RB cord-015021-pol2qm74 6754 16 30 30 CD cord-015021-pol2qm74 6754 17 min min NN cord-015021-pol2qm74 6754 18 after after IN cord-015021-pol2qm74 6754 19 sepsis sepsis NN cord-015021-pol2qm74 6754 20 induction induction NN cord-015021-pol2qm74 6754 21 . . . cord-015021-pol2qm74 6755 1 Concomitantly concomitantly RB cord-015021-pol2qm74 6755 2 , , , cord-015021-pol2qm74 6755 3 tissue tissue NN cord-015021-pol2qm74 6755 4 GSH GSH NNP cord-015021-pol2qm74 6755 5 level level NN cord-015021-pol2qm74 6755 6 decreased decrease VBD cord-015021-pol2qm74 6755 7 and and CC cord-015021-pol2qm74 6755 8 lipid lipid NN cord-015021-pol2qm74 6755 9 peroxidation peroxidation NN cord-015021-pol2qm74 6755 10 was be VBD cord-015021-pol2qm74 6755 11 pronounced pronounce VBN cord-015021-pol2qm74 6755 12 as as IN cord-015021-pol2qm74 6755 13 shown show VBN cord-015021-pol2qm74 6755 14 by by IN cord-015021-pol2qm74 6755 15 elevated elevated JJ cord-015021-pol2qm74 6755 16 MDA MDA NNP cord-015021-pol2qm74 6755 17 and and CC cord-015021-pol2qm74 6755 18 CD CD NNP cord-015021-pol2qm74 6755 19 levels level NNS cord-015021-pol2qm74 6755 20 . . . cord-015021-pol2qm74 6756 1 DFO DFO NNP cord-015021-pol2qm74 6756 2 - - HYPH cord-015021-pol2qm74 6756 3 HES HES NNP cord-015021-pol2qm74 6756 4 diminished diminish VBD cord-015021-pol2qm74 6756 5 tissue tissue NN cord-015021-pol2qm74 6756 6 PMN pmn NN cord-015021-pol2qm74 6756 7 accumulation accumulation NN cord-015021-pol2qm74 6756 8 and and CC cord-015021-pol2qm74 6756 9 MPO MPO NNP cord-015021-pol2qm74 6756 10 concentration concentration NN cord-015021-pol2qm74 6756 11 . . . cord-015021-pol2qm74 6757 1 Moreover moreover RB cord-015021-pol2qm74 6757 2 , , , cord-015021-pol2qm74 6757 3 at at IN cord-015021-pol2qm74 6757 4 each each DT cord-015021-pol2qm74 6757 5 time time NN cord-015021-pol2qm74 6757 6 point point NN cord-015021-pol2qm74 6757 7 lung lung NN cord-015021-pol2qm74 6757 8 MDA MDA NNP cord-015021-pol2qm74 6757 9 and and CC cord-015021-pol2qm74 6757 10 CD CD NNP cord-015021-pol2qm74 6757 11 levels level NNS cord-015021-pol2qm74 6757 12 were be VBD cord-015021-pol2qm74 6757 13 lower low JJR cord-015021-pol2qm74 6757 14 ( ( -LRB- cord-015021-pol2qm74 6757 15 p<0.02 p<0.02 NN cord-015021-pol2qm74 6757 16 ) ) -RRB- cord-015021-pol2qm74 6757 17 . . . cord-015021-pol2qm74 6758 1 Histomorphological histomorphological JJ cord-015021-pol2qm74 6758 2 examination examination NN cord-015021-pol2qm74 6758 3 showed show VBD cord-015021-pol2qm74 6758 4 marked mark VBN cord-015021-pol2qm74 6758 5 micro micro NN cord-015021-pol2qm74 6758 6 - - HYPH cord-015021-pol2qm74 6758 7 atelectases atelectase NNS cord-015021-pol2qm74 6758 8 , , , cord-015021-pol2qm74 6758 9 destruction destruction NN cord-015021-pol2qm74 6758 10 of of IN cord-015021-pol2qm74 6758 11 the the DT cord-015021-pol2qm74 6758 12 alveolar alveolar JJ cord-015021-pol2qm74 6758 13 septa septa NNP cord-015021-pol2qm74 6758 14 , , , cord-015021-pol2qm74 6758 15 and and CC cord-015021-pol2qm74 6758 16 splicing splicing NN cord-015021-pol2qm74 6758 17 of of IN cord-015021-pol2qm74 6758 18 the the DT cord-015021-pol2qm74 6758 19 basal basal NN cord-015021-pol2qm74 6758 20 membranes membrane NNS cord-015021-pol2qm74 6758 21 in in IN cord-015021-pol2qm74 6758 22 the the DT cord-015021-pol2qm74 6758 23 lIES lies JJ cord-015021-pol2qm74 6758 24 group group NN cord-015021-pol2qm74 6758 25 . . . cord-015021-pol2qm74 6759 1 In in IN cord-015021-pol2qm74 6759 2 contrast contrast NN cord-015021-pol2qm74 6759 3 , , , cord-015021-pol2qm74 6759 4 in in IN cord-015021-pol2qm74 6759 5 DFO DFO NNP cord-015021-pol2qm74 6759 6 - - HYPH cord-015021-pol2qm74 6759 7 HES HES NNP cord-015021-pol2qm74 6759 8 treated treat VBD cord-015021-pol2qm74 6759 9 rats rat NNS cord-015021-pol2qm74 6759 10 the the DT cord-015021-pol2qm74 6759 11 alveoli alveolus NNS cord-015021-pol2qm74 6759 12 remained remain VBD cord-015021-pol2qm74 6759 13 well well RB cord-015021-pol2qm74 6759 14 - - HYPH cord-015021-pol2qm74 6759 15 ventiIated ventiiate VBN cord-015021-pol2qm74 6759 16 and and CC cord-015021-pol2qm74 6759 17 only only RB cord-015021-pol2qm74 6759 18 some some DT cord-015021-pol2qm74 6759 19 enlarged enlarged JJ cord-015021-pol2qm74 6759 20 reticular reticular JJ cord-015021-pol2qm74 6759 21 fibers fiber NNS cord-015021-pol2qm74 6759 22 without without IN cord-015021-pol2qm74 6759 23 splicing splicing NN cord-015021-pol2qm74 6759 24 were be VBD cord-015021-pol2qm74 6759 25 observed observe VBN cord-015021-pol2qm74 6759 26 . . . cord-015021-pol2qm74 6760 1 Almost almost RB cord-015021-pol2qm74 6760 2 similar similar JJ cord-015021-pol2qm74 6760 3 results result NNS cord-015021-pol2qm74 6760 4 were be VBD cord-015021-pol2qm74 6760 5 found find VBN cord-015021-pol2qm74 6760 6 for for IN cord-015021-pol2qm74 6760 7 the the DT cord-015021-pol2qm74 6760 8 kidneys kidney NNS cord-015021-pol2qm74 6760 9 . . . cord-015021-pol2qm74 6761 1 MPO MPO NNP cord-015021-pol2qm74 6761 2 levels level NNS cord-015021-pol2qm74 6761 3 differed differ VBD cord-015021-pol2qm74 6761 4 neither neither CC cord-015021-pol2qm74 6761 5 within within IN cord-015021-pol2qm74 6761 6 nor nor CC cord-015021-pol2qm74 6761 7 between between IN cord-015021-pol2qm74 6761 8 both both DT cord-015021-pol2qm74 6761 9 groups group NNS cord-015021-pol2qm74 6761 10 . . . cord-015021-pol2qm74 6762 1 The the DT cord-015021-pol2qm74 6762 2 slight slight JJ cord-015021-pol2qm74 6762 3 decrease decrease NN cord-015021-pol2qm74 6762 4 in in IN cord-015021-pol2qm74 6762 5 GSH GSH NNP cord-015021-pol2qm74 6762 6 levels level NNS cord-015021-pol2qm74 6762 7 seen see VBN cord-015021-pol2qm74 6762 8 after after IN cord-015021-pol2qm74 6762 9 60 60 CD cord-015021-pol2qm74 6762 10 min min NN cord-015021-pol2qm74 6762 11 in in IN cord-015021-pol2qm74 6762 12 the the DT cord-015021-pol2qm74 6762 13 DFO DFO NNP cord-015021-pol2qm74 6762 14 - - HYPH cord-015021-pol2qm74 6762 15 HES HES NNP cord-015021-pol2qm74 6762 16 group group NN cord-015021-pol2qm74 6762 17 seems seem VBZ cord-015021-pol2qm74 6762 18 to to TO cord-015021-pol2qm74 6762 19 demonstrate demonstrate VB cord-015021-pol2qm74 6762 20 an an DT cord-015021-pol2qm74 6762 21 oxidative oxidative JJ cord-015021-pol2qm74 6762 22 stress stress NN cord-015021-pol2qm74 6762 23 to to IN cord-015021-pol2qm74 6762 24 a a DT cord-015021-pol2qm74 6762 25 lesser less JJR cord-015021-pol2qm74 6762 26 degree degree NN cord-015021-pol2qm74 6762 27 . . . cord-015021-pol2qm74 6763 1 The the DT cord-015021-pol2qm74 6763 2 most most RBS cord-015021-pol2qm74 6763 3 impressive impressive JJ cord-015021-pol2qm74 6763 4 effect effect NN cord-015021-pol2qm74 6763 5 of of IN cord-015021-pol2qm74 6763 6 iron iron NN cord-015021-pol2qm74 6763 7 chelation chelation NN cord-015021-pol2qm74 6763 8 , , , cord-015021-pol2qm74 6763 9 however however RB cord-015021-pol2qm74 6763 10 , , , cord-015021-pol2qm74 6763 11 was be VBD cord-015021-pol2qm74 6763 12 revealed reveal VBN cord-015021-pol2qm74 6763 13 by by IN cord-015021-pol2qm74 6763 14 the the DT cord-015021-pol2qm74 6763 15 lipid lipid NN cord-015021-pol2qm74 6763 16 peroxidation peroxidation NN cord-015021-pol2qm74 6763 17 products product NNS cord-015021-pol2qm74 6763 18 . . . cord-015021-pol2qm74 6764 1 At at IN cord-015021-pol2qm74 6764 2 each each DT cord-015021-pol2qm74 6764 3 time time NN cord-015021-pol2qm74 6764 4 point point NN cord-015021-pol2qm74 6764 5 , , , cord-015021-pol2qm74 6764 6 MDA MDA NNP cord-015021-pol2qm74 6764 7 and and CC cord-015021-pol2qm74 6764 8 CD CD NNP cord-015021-pol2qm74 6764 9 levels level NNS cord-015021-pol2qm74 6764 10 were be VBD cord-015021-pol2qm74 6764 11 lower low JJR cord-015021-pol2qm74 6764 12 ( ( -LRB- cord-015021-pol2qm74 6764 13 p<0.02 p<0.02 NN cord-015021-pol2qm74 6764 14 ) ) -RRB- cord-015021-pol2qm74 6764 15 compared compare VBN cord-015021-pol2qm74 6764 16 to to IN cord-015021-pol2qm74 6764 17 the the DT cord-015021-pol2qm74 6764 18 HES HES NNP cord-015021-pol2qm74 6764 19 group group NN cord-015021-pol2qm74 6764 20 . . . cord-015021-pol2qm74 6765 1 Light light NN cord-015021-pol2qm74 6765 2 and and CC cord-015021-pol2qm74 6765 3 electron electron NN cord-015021-pol2qm74 6765 4 microscopic microscopic JJ cord-015021-pol2qm74 6765 5 examination examination NN cord-015021-pol2qm74 6765 6 disclosed disclose VBD cord-015021-pol2qm74 6765 7 tubulotoxic tubulotoxic NNP cord-015021-pol2qm74 6765 8 and and CC cord-015021-pol2qm74 6765 9 mitochondriat mitochondriat NNP cord-015021-pol2qm74 6765 10 damages damage NNS cord-015021-pol2qm74 6765 11 while while IN cord-015021-pol2qm74 6765 12 DFO DFO NNP cord-015021-pol2qm74 6765 13 - - HYPH cord-015021-pol2qm74 6765 14 HES HES NNP cord-015021-pol2qm74 6765 15 lxeatment lxeatment NN cord-015021-pol2qm74 6765 16 prevented prevent VBD cord-015021-pol2qm74 6765 17 that that IN cord-015021-pol2qm74 6765 18 alterations alteration NNS cord-015021-pol2qm74 6765 19 . . . cord-015021-pol2qm74 6766 1 Conclusion conclusion NN cord-015021-pol2qm74 6766 2 : : : cord-015021-pol2qm74 6766 3 Both both CC cord-015021-pol2qm74 6766 4 the the DT cord-015021-pol2qm74 6766 5 biochemical biochemical JJ cord-015021-pol2qm74 6766 6 and and CC cord-015021-pol2qm74 6766 7 histological histological JJ cord-015021-pol2qm74 6766 8 results result NNS cord-015021-pol2qm74 6766 9 of of IN cord-015021-pol2qm74 6766 10 this this DT cord-015021-pol2qm74 6766 11 study study NN cord-015021-pol2qm74 6766 12 reveal reveal VBP cord-015021-pol2qm74 6766 13 an an DT cord-015021-pol2qm74 6766 14 early early JJ cord-015021-pol2qm74 6766 15 and and CC cord-015021-pol2qm74 6766 16 remarkable remarkable JJ cord-015021-pol2qm74 6766 17 generation generation NN cord-015021-pol2qm74 6766 18 of of IN cord-015021-pol2qm74 6766 19 OR or CC cord-015021-pol2qm74 6766 20 in in IN cord-015021-pol2qm74 6766 21 peritonitis peritonitis NN cord-015021-pol2qm74 6766 22 - - HYPH cord-015021-pol2qm74 6766 23 induced induce VBN cord-015021-pol2qm74 6766 24 sepsis sepsis NN cord-015021-pol2qm74 6766 25 . . . cord-015021-pol2qm74 6767 1 Thereby thereby RB cord-015021-pol2qm74 6767 2 , , , cord-015021-pol2qm74 6767 3 these these DT cord-015021-pol2qm74 6767 4 OR or CC cord-015021-pol2qm74 6767 5 obviously obviously RB cord-015021-pol2qm74 6767 6 cause cause VB cord-015021-pol2qm74 6767 7 pulmonary pulmonary JJ cord-015021-pol2qm74 6767 8 and and CC cord-015021-pol2qm74 6767 9 renal renal JJ cord-015021-pol2qm74 6767 10 tissue tissue NN cord-015021-pol2qm74 6767 11 damages damage NNS cord-015021-pol2qm74 6767 12 , , , cord-015021-pol2qm74 6767 13 intravenous intravenous JJ cord-015021-pol2qm74 6767 14 application application NN cord-015021-pol2qm74 6767 15 of of IN cord-015021-pol2qm74 6767 16 DFO DFO NNP cord-015021-pol2qm74 6767 17 - - HYPH cord-015021-pol2qm74 6767 18 HES HES NNP cord-015021-pol2qm74 6767 19 may may MD cord-015021-pol2qm74 6767 20 , , , cord-015021-pol2qm74 6767 21 however however RB cord-015021-pol2qm74 6767 22 , , , cord-015021-pol2qm74 6767 23 benefit benefit VBP cord-015021-pol2qm74 6767 24 by by IN cord-015021-pol2qm74 6767 25 preventing prevent VBG cord-015021-pol2qm74 6767 26 early early JJ cord-015021-pol2qm74 6767 27 lipid lipid NN cord-015021-pol2qm74 6767 28 peroxidation peroxidation NN cord-015021-pol2qm74 6767 29 of of IN cord-015021-pol2qm74 6767 30 the the DT cord-015021-pol2qm74 6767 31 tissue tissue NN cord-015021-pol2qm74 6767 32 . . . cord-015021-pol2qm74 6768 1 The the DT cord-015021-pol2qm74 6768 2 proteolytic proteolytic JJ cord-015021-pol2qm74 6768 3 irreversible irreversible JJ cord-015021-pol2qm74 6768 4 COnversion conversion NN cord-015021-pol2qm74 6768 5 of of IN cord-015021-pol2qm74 6768 6 xanthine xanthine NN cord-015021-pol2qm74 6768 7 dehydrogenase dehydrogenase NN cord-015021-pol2qm74 6768 8 ( ( -LRB- cord-015021-pol2qm74 6768 9 XD XD NNP cord-015021-pol2qm74 6768 10 ) ) -RRB- cord-015021-pol2qm74 6768 11 to to IN cord-015021-pol2qm74 6768 12 xanthine xanthine NN cord-015021-pol2qm74 6768 13 Oxidase Oxidase NNP cord-015021-pol2qm74 6768 14 ( ( -LRB- cord-015021-pol2qm74 6768 15 XO XO NNP cord-015021-pol2qm74 6768 16 ) ) -RRB- cord-015021-pol2qm74 6768 17 is be VBZ cord-015021-pol2qm74 6768 18 triggered trigger VBN cord-015021-pol2qm74 6768 19 by by IN cord-015021-pol2qm74 6768 20 calcium calcium NN cord-015021-pol2qm74 6768 21 flux flux NN cord-015021-pol2qm74 6768 22 . . . cord-015021-pol2qm74 6769 1 The the DT cord-015021-pol2qm74 6769 2 aim aim NN cord-015021-pol2qm74 6769 3 of of IN cord-015021-pol2qm74 6769 4 our -PRON- PRP$ cord-015021-pol2qm74 6769 5 study study NN cord-015021-pol2qm74 6769 6 is be VBZ cord-015021-pol2qm74 6769 7 to to TO cord-015021-pol2qm74 6769 8 clarify clarify VB cord-015021-pol2qm74 6769 9 ~he ~he NNP cord-015021-pol2qm74 6769 10 link link VB cord-015021-pol2qm74 6769 11 between between IN cord-015021-pol2qm74 6769 12 intracellular intracellular JJ cord-015021-pol2qm74 6769 13 Ca2 ca2 CD cord-015021-pol2qm74 6769 14 + + SYM cord-015021-pol2qm74 6769 15 levels level NNS cord-015021-pol2qm74 6769 16 and and CC cord-015021-pol2qm74 6769 17 XO XO NNP cord-015021-pol2qm74 6769 18 activity activity NN cord-015021-pol2qm74 6769 19 determined determine VBN cord-015021-pol2qm74 6769 20 by by IN cord-015021-pol2qm74 6769 21 uric uric NN cord-015021-pol2qm74 6769 22 acid acid NN cord-015021-pol2qm74 6769 23 release release NN cord-015021-pol2qm74 6769 24 , , , cord-015021-pol2qm74 6769 25 and and CC cord-015021-pol2qm74 6769 26 to to TO cord-015021-pol2qm74 6769 27 evaluate evaluate VB cord-015021-pol2qm74 6769 28 the the DT cord-015021-pol2qm74 6769 29 efficacy efficacy NN cord-015021-pol2qm74 6769 30 of of IN cord-015021-pol2qm74 6769 31 verapamil verapamil NN cord-015021-pol2qm74 6769 32 , , , cord-015021-pol2qm74 6769 33 on on IN cord-015021-pol2qm74 6769 34 the the DT cord-015021-pol2qm74 6769 35 generation generation NN cord-015021-pol2qm74 6769 36 of of IN cord-015021-pol2qm74 6769 37 hydrogen hydrogen NN cord-015021-pol2qm74 6769 38 peroxide peroxide NN cord-015021-pol2qm74 6769 39 associated associate VBN cord-015021-pol2qm74 6769 40 with with IN cord-015021-pol2qm74 6769 41 reperfusion reperfusion NN cord-015021-pol2qm74 6769 42 by by IN cord-015021-pol2qm74 6769 43 assaying assay VBG cord-015021-pol2qm74 6769 44 lactate lactate NN cord-015021-pol2qm74 6769 45 & & CC cord-015021-pol2qm74 6769 46 pyruva pyruva NNP cord-015021-pol2qm74 6769 47 ~ ~ NFP cord-015021-pol2qm74 6769 48 e e NN cord-015021-pol2qm74 6769 49 release release NN cord-015021-pol2qm74 6769 50 and and CC cord-015021-pol2qm74 6769 51 the the DT cord-015021-pol2qm74 6769 52 levels level NNS cord-015021-pol2qm74 6769 53 of of IN cord-015021-pol2qm74 6769 54 cytosolic cytosolic JJ cord-015021-pol2qm74 6769 55 free free JJ cord-015021-pol2qm74 6769 56 NAD NAD NNP cord-015021-pol2qm74 6769 57 /NADH /NADH : cord-015021-pol2qm74 6769 58 ratio ratio NN cord-015021-pol2qm74 6769 59 . . . cord-015021-pol2qm74 6770 1 Experimental experimental JJ cord-015021-pol2qm74 6770 2 protocol protocol NN cord-015021-pol2qm74 6770 3 consisted consist VBD cord-015021-pol2qm74 6770 4 of of IN cord-015021-pol2qm74 6770 5 : : : cord-015021-pol2qm74 6770 6 ( ( -LRB- cord-015021-pol2qm74 6770 7 A a NN cord-015021-pol2qm74 6770 8 ) ) -RRB- cord-015021-pol2qm74 6770 9 Non non JJ cord-015021-pol2qm74 6770 10 ischemic ischemic JJ cord-015021-pol2qm74 6770 11 / / SYM cord-015021-pol2qm74 6770 12 reperfused reperfused JJ cord-015021-pol2qm74 6770 13 experiment experiment NN cord-015021-pol2qm74 6770 14 in in IN cord-015021-pol2qm74 6770 15 which which WDT cord-015021-pol2qm74 6770 16 normal normal JJ cord-015021-pol2qm74 6770 17 cardiac cardiac JJ cord-015021-pol2qm74 6770 18 slices slice NNS cord-015021-pol2qm74 6770 19 of of IN cord-015021-pol2qm74 6770 20 rats rat NNS cord-015021-pol2qm74 6770 21 were be VBD cord-015021-pol2qm74 6770 22 perfusated perfusate VBN cord-015021-pol2qm74 6770 23 with with IN cord-015021-pol2qm74 6770 24 oxygenated oxygenated JJ cord-015021-pol2qm74 6770 25 kreb kreb NNP cord-015021-pol2qm74 6770 26 's 's POS cord-015021-pol2qm74 6770 27 Ringer Ringer NNP cord-015021-pol2qm74 6770 28 phosphate phosphate NN cord-015021-pol2qm74 6770 29 buffer buffer NN cord-015021-pol2qm74 6770 30 containing contain VBG cord-015021-pol2qm74 6770 31 glucose glucose NN cord-015021-pol2qm74 6770 32 ( ( -LRB- cord-015021-pol2qm74 6770 33 150mg% 150mg% CD cord-015021-pol2qm74 6770 34 ) ) -RRB- cord-015021-pol2qm74 6770 35 and and CC cord-015021-pol2qm74 6770 36 bovine bovine JJ cord-015021-pol2qm74 6770 37 albumine albumine NN cord-015021-pol2qm74 6770 38 ( ( -LRB- cord-015021-pol2qm74 6770 39 5gm% 5gm% CD cord-015021-pol2qm74 6770 40 ) ) -RRB- cord-015021-pol2qm74 6770 41 for for IN cord-015021-pol2qm74 6770 42 60min 60min NN cord-015021-pol2qm74 6770 43 at at IN cord-015021-pol2qm74 6770 44 37 37 CD cord-015021-pol2qm74 6770 45 ° ° NNS cord-015021-pol2qm74 6770 46 C.It C.It NNP cord-015021-pol2qm74 6770 47 composed compose VBN cord-015021-pol2qm74 6770 48 of of IN cord-015021-pol2qm74 6770 49 3 3 CD cord-015021-pol2qm74 6770 50 groups group NNS cord-015021-pol2qm74 6770 51 , , , cord-015021-pol2qm74 6770 52 group group NN cord-015021-pol2qm74 6770 53 Aa Aa NNP cord-015021-pol2qm74 6770 54 ( ( -LRB- cord-015021-pol2qm74 6770 55 control control NNP cord-015021-pol2qm74 6770 56 group group NN cord-015021-pol2qm74 6770 57 ) ) -RRB- cord-015021-pol2qm74 6770 58 , , , cord-015021-pol2qm74 6770 59 and and CC cord-015021-pol2qm74 6770 60 groups group NNS cord-015021-pol2qm74 6770 61 Ab Ab NNP cord-015021-pol2qm74 6770 62 & & CC cord-015021-pol2qm74 6770 63 Ac Ac NNP cord-015021-pol2qm74 6770 64 ( ( -LRB- cord-015021-pol2qm74 6770 65 perfusate perfusate NN cord-015021-pol2qm74 6770 66 supplemented supplement VBN cord-015021-pol2qm74 6770 67 with with IN cord-015021-pol2qm74 6770 68 verapamil verapamil NN cord-015021-pol2qm74 6770 69 in in IN cord-015021-pol2qm74 6770 70 the the DT cord-015021-pol2qm74 6770 71 dose dose NN cord-015021-pol2qm74 6770 72 of of IN cord-015021-pol2qm74 6770 73 lOO&200 loo&200 NN cord-015021-pol2qm74 6770 74 mi% mi% NNP cord-015021-pol2qm74 6770 75 respectively respectively RB cord-015021-pol2qm74 6770 76 ) ) -RRB- cord-015021-pol2qm74 6770 77 . . . cord-015021-pol2qm74 6771 1 ( ( -LRB- cord-015021-pol2qm74 6771 2 B b NN cord-015021-pol2qm74 6771 3 ) ) -RRB- cord-015021-pol2qm74 6772 1 Ischemic ischemic JJ cord-015021-pol2qm74 6772 2 reperfused reperfused JJ cord-015021-pol2qm74 6772 3 experiment experiment NN cord-015021-pol2qm74 6772 4 in in IN cord-015021-pol2qm74 6772 5 which which WDT cord-015021-pol2qm74 6772 6 ischemic ischemic JJ cord-015021-pol2qm74 6772 7 cardiac cardiac JJ cord-015021-pol2qm74 6772 8 slices slice NNS cord-015021-pol2qm74 6772 9 were be VBD cord-015021-pol2qm74 6772 10 obtained obtain VBN cord-015021-pol2qm74 6772 11 from from IN cord-015021-pol2qm74 6772 12 rats rat NNS cord-015021-pol2qm74 6772 13 subjected subject VBN cord-015021-pol2qm74 6772 14 to to IN cord-015021-pol2qm74 6772 15 15 15 CD cord-015021-pol2qm74 6772 16 min min NN cord-015021-pol2qm74 6773 1 ~aemorrhage.lt ~aemorrhage.lt JJ cord-015021-pol2qm74 6773 2 was be VBD cord-015021-pol2qm74 6773 3 also also RB cord-015021-pol2qm74 6773 4 divided divide VBN cord-015021-pol2qm74 6773 5 into into IN cord-015021-pol2qm74 6773 6 two two CD cord-015021-pol2qm74 6773 7 groups group NNS cord-015021-pol2qm74 6773 8 ; ; : cord-015021-pol2qm74 6773 9 group group NN cord-015021-pol2qm74 6773 10 Ba Ba NNP cord-015021-pol2qm74 6773 11 and and CC cord-015021-pol2qm74 6773 12 Bb Bb NNP cord-015021-pol2qm74 6773 13 ( ( -LRB- cord-015021-pol2qm74 6773 14 verapam~/ verapam~/ `` cord-015021-pol2qm74 6773 15 200mi% 200mi% CD cord-015021-pol2qm74 6773 16 added add VBD cord-015021-pol2qm74 6773 17 to to IN cord-015021-pol2qm74 6773 18 perfusate perfusate VB cord-015021-pol2qm74 6773 19 } } -RRB- cord-015021-pol2qm74 6773 20 . . . cord-015021-pol2qm74 6774 1 Verapamil verapamil NN cord-015021-pol2qm74 6774 2 stimulated stimulate VBD cord-015021-pol2qm74 6774 3 uric uric NN cord-015021-pol2qm74 6774 4 acid acid NN cord-015021-pol2qm74 6774 5 release release NN cord-015021-pol2qm74 6774 6 from from IN cord-015021-pol2qm74 6774 7 normal normal JJ cord-015021-pol2qm74 6774 8 rat rat NN cord-015021-pol2qm74 6774 9 cardiac cardiac JJ cord-015021-pol2qm74 6774 10 slices slice NNS cord-015021-pol2qm74 6774 11 were be VBD cord-015021-pol2qm74 6774 12 267 267 CD cord-015021-pol2qm74 6774 13 % % NN cord-015021-pol2qm74 6774 14 in in IN cord-015021-pol2qm74 6774 15 group group NN cord-015021-pol2qm74 6774 16 Ab Ab NNP cord-015021-pol2qm74 6774 17 and and CC cord-015021-pol2qm74 6774 18 767 767 CD cord-015021-pol2qm74 6774 19 % % NN cord-015021-pol2qm74 6774 20 in in IN cord-015021-pol2qm74 6774 21 group group NN cord-015021-pol2qm74 6775 1 Ac(dose ac(dose RB cord-015021-pol2qm74 6775 2 related relate VBN cord-015021-pol2qm74 6775 3 ) ) -RRB- cord-015021-pol2qm74 6775 4 . . . cord-015021-pol2qm74 6776 1 Rates rate NNS cord-015021-pol2qm74 6776 2 of of IN cord-015021-pol2qm74 6776 3 uric uric NN cord-015021-pol2qm74 6776 4 acid acid NN cord-015021-pol2qm74 6776 5 release release NN cord-015021-pol2qm74 6776 6 is be VBZ cord-015021-pol2qm74 6776 7 enhanced enhance VBN cord-015021-pol2qm74 6776 8 by by IN cord-015021-pol2qm74 6776 9 verapamil verapamil NN cord-015021-pol2qm74 6776 10 in in IN cord-015021-pol2qm74 6776 11 group group NN cord-015021-pol2qm74 6776 12 Bb Bb NNP cord-015021-pol2qm74 6776 13 . . . cord-015021-pol2qm74 6777 1 Moreover moreover RB cord-015021-pol2qm74 6777 2 , , , cord-015021-pol2qm74 6777 3 rates rate NNS cord-015021-pol2qm74 6777 4 of of IN cord-015021-pol2qm74 6777 5 uric uric NN cord-015021-pol2qm74 6777 6 acid acid NN cord-015021-pol2qm74 6777 7 release release NN cord-015021-pol2qm74 6777 8 in in IN cord-015021-pol2qm74 6777 9 groups group NNS cord-015021-pol2qm74 6777 10 Ac Ac NNP cord-015021-pol2qm74 6777 11 & & CC cord-015021-pol2qm74 6777 12 Bb Bb NNP cord-015021-pol2qm74 6777 13 are be VBP cord-015021-pol2qm74 6777 14 insignificant insignificant JJ cord-015021-pol2qm74 6777 15 . . . cord-015021-pol2qm74 6778 1 In in IN cord-015021-pol2qm74 6778 2 verapmil verapmil NN cord-015021-pol2qm74 6778 3 added add VBD cord-015021-pol2qm74 6778 4 groups group NNS cord-015021-pol2qm74 6778 5 ( ( -LRB- cord-015021-pol2qm74 6778 6 group group NN cord-015021-pol2qm74 6778 7 Ab Ab NNP cord-015021-pol2qm74 6778 8 , , , cord-015021-pol2qm74 6778 9 Ac Ac NNP cord-015021-pol2qm74 6778 10 & & CC cord-015021-pol2qm74 6778 11 Bb Bb NNP cord-015021-pol2qm74 6778 12 ) ) -RRB- cord-015021-pol2qm74 6778 13 , , , cord-015021-pol2qm74 6778 14 increase increase VB cord-015021-pol2qm74 6778 15 uric uric NN cord-015021-pol2qm74 6778 16 acid acid NN cord-015021-pol2qm74 6778 17 release release NN cord-015021-pol2qm74 6778 18 is be VBZ cord-015021-pol2qm74 6778 19 associated associate VBN cord-015021-pol2qm74 6778 20 with with IN cord-015021-pol2qm74 6778 21 an an DT cord-015021-pol2qm74 6778 22 enhancement enhancement NN cord-015021-pol2qm74 6778 23 in in IN cord-015021-pol2qm74 6778 24 pyrurate pyrurate NNP cord-015021-pol2qm74 6778 25 release release NN cord-015021-pol2qm74 6778 26 and and CC cord-015021-pol2qm74 6778 27 with with IN cord-015021-pol2qm74 6778 28 increase increase NN cord-015021-pol2qm74 6778 29 levels level NNS cord-015021-pol2qm74 6778 30 of of IN cord-015021-pol2qm74 6778 31 cytosolic cytosolic JJ cord-015021-pol2qm74 6778 32 free free JJ cord-015021-pol2qm74 6778 33 NAD+/NADH NAD+/NADH NNP cord-015021-pol2qm74 6778 34 ratio ratio NN cord-015021-pol2qm74 6778 35 , , , cord-015021-pol2qm74 6778 36 although although IN cord-015021-pol2qm74 6778 37 it -PRON- PRP cord-015021-pol2qm74 6778 38 is be VBZ cord-015021-pol2qm74 6778 39 not not RB cord-015021-pol2qm74 6778 40 evident evident JJ cord-015021-pol2qm74 6778 41 ~ ~ NFP cord-015021-pol2qm74 6778 42 ischemic ischemic JJ cord-015021-pol2qm74 6778 43 group group NN cord-015021-pol2qm74 6778 44 ( ( -LRB- cord-015021-pol2qm74 6778 45 group group NN cord-015021-pol2qm74 6778 46 Ba).It Ba).It NNP cord-015021-pol2qm74 6778 47 is be VBZ cord-015021-pol2qm74 6778 48 concluded conclude VBN cord-015021-pol2qm74 6778 49 that that IN cord-015021-pol2qm74 6778 50 the the DT cord-015021-pol2qm74 6778 51 conversion conversion NN cord-015021-pol2qm74 6778 52 of of IN cord-015021-pol2qm74 6778 53 XD XD NNP cord-015021-pol2qm74 6778 54 to to IN cord-015021-pol2qm74 6778 55 XO XO NNP cord-015021-pol2qm74 6778 56 is be VBZ cord-015021-pol2qm74 6778 57 calcium calcium NN cord-015021-pol2qm74 6778 58 independent independent JJ cord-015021-pol2qm74 6778 59 . . . cord-015021-pol2qm74 6779 1 Eicosanoids Eicosanoids NNP cord-015021-pol2qm74 6779 2 like like IN cord-015021-pol2qm74 6779 3 thromboxane thromboxane NN cord-015021-pol2qm74 6779 4 A2 A2 NNP cord-015021-pol2qm74 6779 5 , , , cord-015021-pol2qm74 6779 6 leukotriene leukotriene NN cord-015021-pol2qm74 6779 7 B4 B4 NNP cord-015021-pol2qm74 6779 8 and and CC cord-015021-pol2qm74 6779 9 leukotriene leukotriene NN cord-015021-pol2qm74 6779 10 C4 C4 NNP cord-015021-pol2qm74 6779 11 are be VBP cord-015021-pol2qm74 6779 12 known know VBN cord-015021-pol2qm74 6779 13 as as IN cord-015021-pol2qm74 6779 14 promoters promoter NNS cord-015021-pol2qm74 6779 15 of of IN cord-015021-pol2qm74 6779 16 initial initial JJ cord-015021-pol2qm74 6779 17 inflammatory inflammatory JJ cord-015021-pol2qm74 6779 18 reactions reaction NNS cord-015021-pol2qm74 6779 19 . . . cord-015021-pol2qm74 6780 1 We -PRON- PRP cord-015021-pol2qm74 6780 2 investigated investigate VBD cord-015021-pol2qm74 6780 3 whether whether IN cord-015021-pol2qm74 6780 4 oxygen oxygen NN cord-015021-pol2qm74 6780 5 radicals radical NNS cord-015021-pol2qm74 6780 6 ( ( -LRB- cord-015021-pol2qm74 6780 7 OR or CC cord-015021-pol2qm74 6780 8 ) ) -RRB- cord-015021-pol2qm74 6780 9 are be VBP cord-015021-pol2qm74 6780 10 able able JJ cord-015021-pol2qm74 6780 11 to to TO cord-015021-pol2qm74 6780 12 induce induce VB cord-015021-pol2qm74 6780 13 a a DT cord-015021-pol2qm74 6780 14 release release NN cord-015021-pol2qm74 6780 15 of of IN cord-015021-pol2qm74 6780 16 these these DT cord-015021-pol2qm74 6780 17 eicosanoids eicosanoid NNS cord-015021-pol2qm74 6780 18 in in IN cord-015021-pol2qm74 6780 19 whole whole JJ cord-015021-pol2qm74 6780 20 blood blood NN cord-015021-pol2qm74 6780 21 . . . cord-015021-pol2qm74 6781 1 Blood blood NN cord-015021-pol2qm74 6781 2 from from IN cord-015021-pol2qm74 6781 3 healthy healthy JJ cord-015021-pol2qm74 6781 4 volunteers volunteer NNS cord-015021-pol2qm74 6781 5 was be VBD cord-015021-pol2qm74 6781 6 incubated incubate VBN cord-015021-pol2qm74 6781 7 with with IN cord-015021-pol2qm74 6781 8 xanthine xanthine NN cord-015021-pol2qm74 6781 9 oxidase oxidase NN cord-015021-pol2qm74 6781 10 / / SYM cord-015021-pol2qm74 6781 11 hypoxanthine hypoxanthine NN cord-015021-pol2qm74 6781 12 to to TO cord-015021-pol2qm74 6781 13 generate generate VB cord-015021-pol2qm74 6781 14 oxygen oxygen NN cord-015021-pol2qm74 6781 15 radicals radical NNS cord-015021-pol2qm74 6781 16 . . . cord-015021-pol2qm74 6782 1 After after IN cord-015021-pol2qm74 6782 2 0,5,15,30 0,5,15,30 CD cord-015021-pol2qm74 6782 3 and and CC cord-015021-pol2qm74 6782 4 60 60 CD cord-015021-pol2qm74 6782 5 minutes minute NNS cord-015021-pol2qm74 6782 6 plasma plasma NN cord-015021-pol2qm74 6782 7 levels level NNS cord-015021-pol2qm74 6782 8 of of IN cord-015021-pol2qm74 6782 9 thromboxane thromboxane NN cord-015021-pol2qm74 6782 10 B2 b2 NN cord-015021-pol2qm74 6782 11 ( ( -LRB- cord-015021-pol2qm74 6782 12 TxB2 TxB2 NNP cord-015021-pol2qm74 6782 13 ) ) -RRB- cord-015021-pol2qm74 6782 14 , , , cord-015021-pol2qm74 6782 15 leukotriene leukotriene NN cord-015021-pol2qm74 6782 16 B4 B4 NNP cord-015021-pol2qm74 6782 17 ( ( -LRB- cord-015021-pol2qm74 6782 18 LTB4 LTB4 NNP cord-015021-pol2qm74 6782 19 ) ) -RRB- cord-015021-pol2qm74 6782 20 and and CC cord-015021-pol2qm74 6782 21 leukotriene leukotriene NN cord-015021-pol2qm74 6782 22 C4 c4 NN cord-015021-pol2qm74 6782 23 ( ( -LRB- cord-015021-pol2qm74 6782 24 LTC4 LTC4 NNP cord-015021-pol2qm74 6782 25 ) ) -RRB- cord-015021-pol2qm74 6782 26 were be VBD cord-015021-pol2qm74 6782 27 determined determine VBN cord-015021-pol2qm74 6782 28 via via IN cord-015021-pol2qm74 6782 29 ELISA ELISA NNP cord-015021-pol2qm74 6782 30 technique technique NN cord-015021-pol2qm74 6782 31 . . . cord-015021-pol2qm74 6783 1 Another another DT cord-015021-pol2qm74 6783 2 volunteer volunteer NN cord-015021-pol2qm74 6783 3 had have VBD cord-015021-pol2qm74 6783 4 taken take VBN cord-015021-pol2qm74 6783 5 1000 1000 CD cord-015021-pol2qm74 6783 6 mg mg NNP cord-015021-pol2qm74 6783 7 Aspirin Aspirin NNP cord-015021-pol2qm74 6783 8 one one CD cord-015021-pol2qm74 6783 9 day day NN cord-015021-pol2qm74 6783 10 before before IN cord-015021-pol2qm74 6783 11 taking take VBG cord-015021-pol2qm74 6783 12 the the DT cord-015021-pol2qm74 6783 13 blood blood NN cord-015021-pol2qm74 6783 14 sample sample NN cord-015021-pol2qm74 6783 15 ( ( -LRB- cord-015021-pol2qm74 6783 16 no7 no7 NNP cord-015021-pol2qm74 6783 17 ) ) -RRB- cord-015021-pol2qm74 6783 18 . . . cord-015021-pol2qm74 6784 1 Results result NNS cord-015021-pol2qm74 6784 2 : : : cord-015021-pol2qm74 6785 1 TxB2 txb2 JJ cord-015021-pol2qm74 6785 2 plasma plasma NN cord-015021-pol2qm74 6785 3 levels level NNS cord-015021-pol2qm74 6785 4 increased increase VBD cord-015021-pol2qm74 6785 5 from from IN cord-015021-pol2qm74 6785 6 14pg 14pg NN cord-015021-pol2qm74 6785 7 / / SYM cord-015021-pol2qm74 6785 8 ml ml XX cord-015021-pol2qm74 6785 9 at at IN cord-015021-pol2qm74 6785 10 0min 0min CD cord-015021-pol2qm74 6785 11 to to IN cord-015021-pol2qm74 6786 1 144pg 144pg NNP cord-015021-pol2qm74 6786 2 / / SYM cord-015021-pol2qm74 6786 3 ml ml NN cord-015021-pol2qm74 6786 4 , , , cord-015021-pol2qm74 6786 5 350pg 350pg NNP cord-015021-pol2qm74 6786 6 / / SYM cord-015021-pol2qm74 6786 7 ml ml XX cord-015021-pol2qm74 6786 8 , , , cord-015021-pol2qm74 6786 9 370pg 370pg NNP cord-015021-pol2qm74 6786 10 / / SYM cord-015021-pol2qm74 6786 11 ml ml NN cord-015021-pol2qm74 6786 12 and and CC cord-015021-pol2qm74 6786 13 660pg 660pg NNP cord-015021-pol2qm74 6786 14 / / SYM cord-015021-pol2qm74 6786 15 ml ml XX cord-015021-pol2qm74 6786 16 at at IN cord-015021-pol2qm74 6786 17 5,15,30 5,15,30 CD cord-015021-pol2qm74 6786 18 and and CC cord-015021-pol2qm74 6786 19 60min 60min NN cord-015021-pol2qm74 6786 20 ( ( -LRB- cord-015021-pol2qm74 6786 21 p<0,01 p<0,01 NN cord-015021-pol2qm74 6786 22 ) ) -RRB- cord-015021-pol2qm74 6786 23 . . . cord-015021-pol2qm74 6787 1 LTB4 LTB4 NNP cord-015021-pol2qm74 6787 2 and and CC cord-015021-pol2qm74 6787 3 LTC4 LTC4 NNP cord-015021-pol2qm74 6787 4 plasma plasma NN cord-015021-pol2qm74 6787 5 levels level NNS cord-015021-pol2qm74 6787 6 showed show VBD cord-015021-pol2qm74 6787 7 an an DT cord-015021-pol2qm74 6787 8 increase increase NN cord-015021-pol2qm74 6787 9 during during IN cord-015021-pol2qm74 6787 10 the the DT cord-015021-pol2qm74 6787 11 first first JJ cord-015021-pol2qm74 6787 12 few few JJ cord-015021-pol2qm74 6787 13 minutes minute NNS cord-015021-pol2qm74 6787 14 ( ( -LRB- cord-015021-pol2qm74 6787 15 LTB4 ltb4 NN cord-015021-pol2qm74 6787 16 : : : cord-015021-pol2qm74 6787 17 0min 0min CD cord-015021-pol2qm74 6787 18 : : : cord-015021-pol2qm74 6787 19 llpg llpg CC cord-015021-pol2qm74 6787 20 / / SYM cord-015021-pol2qm74 6787 21 ml,5min ml,5min NNS cord-015021-pol2qm74 6787 22 : : : cord-015021-pol2qm74 6787 23 87pg 87pg NN cord-015021-pol2qm74 6787 24 / / SYM cord-015021-pol2qm74 6787 25 ml ml NN cord-015021-pol2qm74 6787 26 ; ; : cord-015021-pol2qm74 6787 27 LTC4 LTC4 NNP cord-015021-pol2qm74 6787 28 : : : cord-015021-pol2qm74 6787 29 0min 0min CD cord-015021-pol2qm74 6787 30 : : : cord-015021-pol2qm74 6788 1 23pg 23pg NNP cord-015021-pol2qm74 6788 2 / / SYM cord-015021-pol2qm74 6788 3 ml ml XX cord-015021-pol2qm74 6788 4 , , , cord-015021-pol2qm74 6788 5 5min 5min CD cord-015021-pol2qm74 6788 6 : : : cord-015021-pol2qm74 6789 1 97pg 97pg NNP cord-015021-pol2qm74 6789 2 / / SYM cord-015021-pol2qm74 6789 3 ml ml NN cord-015021-pol2qm74 6789 4 ( ( -LRB- cord-015021-pol2qm74 6789 5 p<0,05 p<0,05 NNP cord-015021-pol2qm74 6789 6 ) ) -RRB- cord-015021-pol2qm74 6789 7 ) ) -RRB- cord-015021-pol2qm74 6789 8 followed follow VBN cord-015021-pol2qm74 6789 9 by by IN cord-015021-pol2qm74 6789 10 a a DT cord-015021-pol2qm74 6789 11 decrease decrease NN cord-015021-pol2qm74 6789 12 to to IN cord-015021-pol2qm74 6789 13 normal normal JJ cord-015021-pol2qm74 6789 14 values value NNS cord-015021-pol2qm74 6789 15 at at IN cord-015021-pol2qm74 6789 16 15min 15min NN cord-015021-pol2qm74 6789 17 . . . cord-015021-pol2qm74 6790 1 In in IN cord-015021-pol2qm74 6790 2 the the DT cord-015021-pol2qm74 6790 3 sample sample NN cord-015021-pol2qm74 6790 4 no7 no7 NNP cord-015021-pol2qm74 6790 5 the the DT cord-015021-pol2qm74 6790 6 cyclooxigenase cyclooxigenase NN cord-015021-pol2qm74 6790 7 - - HYPH cord-015021-pol2qm74 6790 8 pathway pathway NN cord-015021-pol2qm74 6790 9 was be VBD cord-015021-pol2qm74 6790 10 completely completely RB cord-015021-pol2qm74 6790 11 inhibited inhibit VBN cord-015021-pol2qm74 6790 12 , , , cord-015021-pol2qm74 6790 13 the the DT cord-015021-pol2qm74 6790 14 TxB2 txb2 JJ cord-015021-pol2qm74 6790 15 plasma plasma NN cord-015021-pol2qm74 6790 16 - - HYPH cord-015021-pol2qm74 6790 17 levels level NNS cord-015021-pol2qm74 6790 18 did do VBD cord-015021-pol2qm74 6790 19 not not RB cord-015021-pol2qm74 6790 20 alter alter VB cord-015021-pol2qm74 6790 21 at at RB cord-015021-pol2qm74 6790 22 all all RB cord-015021-pol2qm74 6790 23 , , , cord-015021-pol2qm74 6790 24 whereas whereas IN cord-015021-pol2qm74 6790 25 LTB4 LTB4 NNP cord-015021-pol2qm74 6790 26 and and CC cord-015021-pol2qm74 6790 27 LTC4-plasma LTC4-plasma NNP cord-015021-pol2qm74 6790 28 levels level NNS cord-015021-pol2qm74 6790 29 were be VBD cord-015021-pol2qm74 6790 30 n't not RB cord-015021-pol2qm74 6790 31 affected affect VBN cord-015021-pol2qm74 6790 32 . . . cord-015021-pol2qm74 6790 33 _SP cord-015021-pol2qm74 6791 1 OPALLOGENEIC OPALLOGENEIC NNP cord-015021-pol2qm74 6791 2 BLOOD blood NN cord-015021-pol2qm74 6791 3 TRANSFUSION transfusion NN cord-015021-pol2qm74 6791 4 Jane Jane NNP cord-015021-pol2qm74 6791 5 Shelby Shelby NNP cord-015021-pol2qm74 6791 6 , , , cord-015021-pol2qm74 6791 7 Ph.D. ph.d. NN cord-015021-pol2qm74 6791 8 , , , cord-015021-pol2qm74 6791 9 and and CC cord-015021-pol2qm74 6791 10 Edward Edward NNP cord-015021-pol2qm74 6791 11 W W NNP cord-015021-pol2qm74 6791 12 , , , cord-015021-pol2qm74 6791 13 Nelson Nelson NNP cord-015021-pol2qm74 6791 14 , , , cord-015021-pol2qm74 6791 15 M.D M.D NNP cord-015021-pol2qm74 6791 16 , , , cord-015021-pol2qm74 6791 17 There there EX cord-015021-pol2qm74 6791 18 have have VBP cord-015021-pol2qm74 6791 19 been be VBN cord-015021-pol2qm74 6791 20 numerous numerous JJ cord-015021-pol2qm74 6791 21 investigations investigation NNS cord-015021-pol2qm74 6791 22 dudng dudng VB cord-015021-pol2qm74 6791 23 the the DT cord-015021-pol2qm74 6791 24 last last JJ cord-015021-pol2qm74 6791 25 two two CD cord-015021-pol2qm74 6791 26 decades decade NNS cord-015021-pol2qm74 6791 27 examining examine VBG cord-015021-pol2qm74 6791 28 the the DT cord-015021-pol2qm74 6791 29 effect effect NN cord-015021-pol2qm74 6791 30 of of IN cord-015021-pol2qm74 6791 31 surgery surgery NN cord-015021-pol2qm74 6791 32 , , , cord-015021-pol2qm74 6791 33 anesthesia anesthesia NN cord-015021-pol2qm74 6791 34 , , , cord-015021-pol2qm74 6791 35 blood blood NN cord-015021-pol2qm74 6791 36 loss loss NN cord-015021-pol2qm74 6791 37 and and CC cord-015021-pol2qm74 6791 38 transfusion transfusion NN cord-015021-pol2qm74 6791 39 on on IN cord-015021-pol2qm74 6791 40 vadous vadous JJ cord-015021-pol2qm74 6791 41 immune immune JJ cord-015021-pol2qm74 6791 42 parameters parameter NNS cord-015021-pol2qm74 6791 43 in in IN cord-015021-pol2qm74 6791 44 humans human NNS cord-015021-pol2qm74 6791 45 and and CC cord-015021-pol2qm74 6791 46 animal animal NN cord-015021-pol2qm74 6791 47 models model NNS cord-015021-pol2qm74 6791 48 . . . cord-015021-pol2qm74 6792 1 There there EX cord-015021-pol2qm74 6792 2 appears appear VBZ cord-015021-pol2qm74 6792 3 to to TO cord-015021-pol2qm74 6792 4 be be VB cord-015021-pol2qm74 6792 5 concurrence concurrence NN cord-015021-pol2qm74 6792 6 among among IN cord-015021-pol2qm74 6792 7 several several JJ cord-015021-pol2qm74 6792 8 well well RB cord-015021-pol2qm74 6792 9 controlled control VBN cord-015021-pol2qm74 6792 10 studies study NNS cord-015021-pol2qm74 6792 11 that that IN cord-015021-pol2qm74 6792 12 transfusion transfusion NN cord-015021-pol2qm74 6792 13 of of IN cord-015021-pol2qm74 6792 14 whole whole JJ cord-015021-pol2qm74 6792 15 blood blood NN cord-015021-pol2qm74 6792 16 ( ( -LRB- cord-015021-pol2qm74 6792 17 containing contain VBG cord-015021-pol2qm74 6792 18 leukocytes leukocyte NNS cord-015021-pol2qm74 6792 19 ) ) -RRB- cord-015021-pol2qm74 6792 20 , , , cord-015021-pol2qm74 6792 21 has have VBZ cord-015021-pol2qm74 6792 22 regulatory regulatory JJ cord-015021-pol2qm74 6792 23 effects effect NNS cord-015021-pol2qm74 6792 24 on on IN cord-015021-pol2qm74 6792 25 immune immune JJ cord-015021-pol2qm74 6792 26 ceil ceil NN cord-015021-pol2qm74 6792 27 function function NN cord-015021-pol2qm74 6792 28 which which WDT cord-015021-pol2qm74 6792 29 include include VBP cord-015021-pol2qm74 6792 30 decreased decrease VBN cord-015021-pol2qm74 6792 31 cell cell NN cord-015021-pol2qm74 6792 32 mediated mediate VBD cord-015021-pol2qm74 6792 33 immune immune JJ cord-015021-pol2qm74 6792 34 response response NN cord-015021-pol2qm74 6792 35 , , , cord-015021-pol2qm74 6792 36 and and CC cord-015021-pol2qm74 6792 37 inhibition inhibition NN cord-015021-pol2qm74 6792 38 of of IN cord-015021-pol2qm74 6792 39 IL-2 IL-2 NNP cord-015021-pol2qm74 6792 40 secretion secretion NN cord-015021-pol2qm74 6792 41 . . . cord-015021-pol2qm74 6793 1 These these DT cord-015021-pol2qm74 6793 2 effects effect NNS cord-015021-pol2qm74 6793 3 occur occur VBP cord-015021-pol2qm74 6793 4 following follow VBG cord-015021-pol2qm74 6793 5 transfusion transfusion NN cord-015021-pol2qm74 6793 6 alone alone RB cord-015021-pol2qm74 6793 7 and and CC cord-015021-pol2qm74 6793 8 in in IN cord-015021-pol2qm74 6793 9 con.cart con.cart NNP cord-015021-pol2qm74 6793 10 with with IN cord-015021-pol2qm74 6793 11 the the DT cord-015021-pol2qm74 6793 12 distinct distinct JJ cord-015021-pol2qm74 6793 13 immune immune JJ cord-015021-pol2qm74 6793 14 effects effect NNS cord-015021-pol2qm74 6793 15 of of IN cord-015021-pol2qm74 6793 16 surgery surgery NN cord-015021-pol2qm74 6793 17 , , , cord-015021-pol2qm74 6793 18 trauma trauma NN cord-015021-pol2qm74 6793 19 and and CC cord-015021-pol2qm74 6793 20 anesthesla anesthesla NN cord-015021-pol2qm74 6793 21 , , , cord-015021-pol2qm74 6793 22 The the DT cord-015021-pol2qm74 6793 23 clinical clinical JJ cord-015021-pol2qm74 6793 24 consequences consequence NNS cord-015021-pol2qm74 6793 25 of of IN cord-015021-pol2qm74 6793 26 this this DT cord-015021-pol2qm74 6793 27 immune immune JJ cord-015021-pol2qm74 6793 28 modulation modulation NN cord-015021-pol2qm74 6793 29 by by IN cord-015021-pol2qm74 6793 30 transfusion transfusion NN cord-015021-pol2qm74 6793 31 include include VBP cord-015021-pol2qm74 6793 32 decreased decrease VBD cord-015021-pol2qm74 6793 33 allogeneic allogeneic IN cord-015021-pol2qm74 6793 34 response response NN cord-015021-pol2qm74 6793 35 to to IN cord-015021-pol2qm74 6793 36 transplanted transplanted JJ cord-015021-pol2qm74 6793 37 organs organ NNS cord-015021-pol2qm74 6793 38 , , , cord-015021-pol2qm74 6793 39 which which WDT cord-015021-pol2qm74 6793 40 has have VBZ cord-015021-pol2qm74 6793 41 been be VBN cord-015021-pol2qm74 6793 42 exploited exploit VBN cord-015021-pol2qm74 6793 43 clinicelly clinicelly RB cord-015021-pol2qm74 6793 44 in in IN cord-015021-pol2qm74 6793 45 renal renal JJ cord-015021-pol2qm74 6793 46 transplant transplant NN cord-015021-pol2qm74 6793 47 patients patient NNS cord-015021-pol2qm74 6793 48 . . . cord-015021-pol2qm74 6794 1 Additionally additionally RB cord-015021-pol2qm74 6794 2 , , , cord-015021-pol2qm74 6794 3 there there EX cord-015021-pol2qm74 6794 4 is be VBZ cord-015021-pol2qm74 6794 5 evidence evidence NN cord-015021-pol2qm74 6794 6 for for IN cord-015021-pol2qm74 6794 7 a a DT cord-015021-pol2qm74 6794 8 strong strong JJ cord-015021-pol2qm74 6794 9 association association NN cord-015021-pol2qm74 6794 10 with with IN cord-015021-pol2qm74 6794 11 increased increase VBN cord-015021-pol2qm74 6794 12 risk risk NN cord-015021-pol2qm74 6794 13 for for IN cord-015021-pol2qm74 6794 14 infection infection NN cord-015021-pol2qm74 6794 15 in in IN cord-015021-pol2qm74 6794 16 transfused transfuse VBN cord-015021-pol2qm74 6794 17 patients patient NNS cord-015021-pol2qm74 6794 18 following follow VBG cord-015021-pol2qm74 6794 19 surgical surgical JJ cord-015021-pol2qm74 6794 20 procedures procedure NNS cord-015021-pol2qm74 6794 21 . . . cord-015021-pol2qm74 6795 1 AIIogeneio AIIogeneio NNS cord-015021-pol2qm74 6795 2 blood blood NN cord-015021-pol2qm74 6795 3 transfusions transfusion NNS cord-015021-pol2qm74 6795 4 have have VBP cord-015021-pol2qm74 6795 5 been be VBN cord-015021-pol2qm74 6795 6 shown show VBN cord-015021-pol2qm74 6795 7 to to TO cord-015021-pol2qm74 6795 8 inhibit inhibit VB cord-015021-pol2qm74 6795 9 cellular cellular JJ cord-015021-pol2qm74 6795 10 anti.bacterial anti.bacterial JJ cord-015021-pol2qm74 6795 11 mechanisms mechanism NNS cord-015021-pol2qm74 6795 12 , , , cord-015021-pol2qm74 6795 13 causing cause VBG cord-015021-pol2qm74 6795 14 increased increase VBN cord-015021-pol2qm74 6795 15 susceptibility susceptibility NN cord-015021-pol2qm74 6795 16 to to IN cord-015021-pol2qm74 6795 17 bacterial bacterial JJ cord-015021-pol2qm74 6795 18 pathogens pathogen NNS cord-015021-pol2qm74 6795 19 , , , cord-015021-pol2qm74 6795 20 in in IN cord-015021-pol2qm74 6795 21 humans human NNS cord-015021-pol2qm74 6795 22 and and CC cord-015021-pol2qm74 6795 23 in in IN cord-015021-pol2qm74 6795 24 animal animal NN cord-015021-pol2qm74 6795 25 models model NNS cord-015021-pol2qm74 6795 26 . . . cord-015021-pol2qm74 6796 1 There there EX cord-015021-pol2qm74 6796 2 is be VBZ cord-015021-pol2qm74 6796 3 also also RB cord-015021-pol2qm74 6796 4 concern concern NN cord-015021-pol2qm74 6796 5 that that IN cord-015021-pol2qm74 6796 6 allog allog NN cord-015021-pol2qm74 6796 7 ~ ~ CD cord-015021-pol2qm74 6796 8 neiC neiC : cord-015021-pol2qm74 6796 9 transfusion transfusion NN cord-015021-pol2qm74 6796 10 may may MD cord-015021-pol2qm74 6796 11 adversely adversely RB cord-015021-pol2qm74 6796 12 affect affect VB cord-015021-pol2qm74 6796 13 cancer cancer NN cord-015021-pol2qm74 6796 14 patients patient NNS cord-015021-pol2qm74 6796 15 , , , cord-015021-pol2qm74 6796 16 resulting result VBG cord-015021-pol2qm74 6796 17 in in IN cord-015021-pol2qm74 6796 18 decreased decreased JJ cord-015021-pol2qm74 6796 19 disease disease NN cord-015021-pol2qm74 6796 20 - - HYPH cord-015021-pol2qm74 6796 21 free free JJ cord-015021-pol2qm74 6796 22 survival survival NN cord-015021-pol2qm74 6796 23 . . . cord-015021-pol2qm74 6797 1 Several several JJ cord-015021-pol2qm74 6797 2 stategies stategie NNS cord-015021-pol2qm74 6797 3 have have VBP cord-015021-pol2qm74 6797 4 been be VBN cord-015021-pol2qm74 6797 5 proposed propose VBN cord-015021-pol2qm74 6797 6 to to TO cord-015021-pol2qm74 6797 7 minimize minimize VB cord-015021-pol2qm74 6797 8 the the DT cord-015021-pol2qm74 6797 9 adverse adverse JJ cord-015021-pol2qm74 6797 10 effects effect NNS cord-015021-pol2qm74 6797 11 of of IN cord-015021-pol2qm74 6797 12 blood blood NN cord-015021-pol2qm74 6797 13 transfusion transfusion NN cord-015021-pol2qm74 6797 14 . . . cord-015021-pol2qm74 6798 1 There there EX cord-015021-pol2qm74 6798 2 is be VBZ cord-015021-pol2qm74 6798 3 evidence evidence NN cord-015021-pol2qm74 6798 4 that that IN cord-015021-pol2qm74 6798 5 the the DT cord-015021-pol2qm74 6798 6 risk risk NN cord-015021-pol2qm74 6798 7 of of IN cord-015021-pol2qm74 6798 8 immune immune JJ cord-015021-pol2qm74 6798 9 mediated mediate VBN cord-015021-pol2qm74 6798 10 infectious infectious JJ cord-015021-pol2qm74 6798 11 complications complication NNS cord-015021-pol2qm74 6798 12 associated associate VBN cord-015021-pol2qm74 6798 13 with with IN cord-015021-pol2qm74 6798 14 transfusion transfusion NN cord-015021-pol2qm74 6798 15 may may MD cord-015021-pol2qm74 6798 16 be be VB cord-015021-pol2qm74 6798 17 greatly greatly RB cord-015021-pol2qm74 6798 18 minimized minimize VBN cord-015021-pol2qm74 6798 19 wlth wlth IN cord-015021-pol2qm74 6798 20 the the DT cord-015021-pol2qm74 6798 21 use use NN cord-015021-pol2qm74 6798 22 of of IN cord-015021-pol2qm74 6798 23 autologous autologous JJ cord-015021-pol2qm74 6798 24 blood blood NN cord-015021-pol2qm74 6798 25 and and CC cord-015021-pol2qm74 6798 26 leukocyte leukocyte NN cord-015021-pol2qm74 6798 27 free free JJ cord-015021-pol2qm74 6798 28 allogeneic allogeneic NN cord-015021-pol2qm74 6798 29 blood.products blood.product NNS cord-015021-pol2qm74 6798 30 in in IN cord-015021-pol2qm74 6798 31 surgical surgical JJ cord-015021-pol2qm74 6798 32 and and CC cord-015021-pol2qm74 6798 33 trauma trauma NN cord-015021-pol2qm74 6798 34 patients patient NNS cord-015021-pol2qm74 6798 35 , , , cord-015021-pol2qm74 6798 36 it -PRON- PRP cord-015021-pol2qm74 6798 37 also also RB cord-015021-pol2qm74 6798 38 appears appear VBZ cord-015021-pol2qm74 6798 39 that that IN cord-015021-pol2qm74 6798 40 the the DT cord-015021-pol2qm74 6798 41 inhibition inhibition NN cord-015021-pol2qm74 6798 42 of of IN cord-015021-pol2qm74 6798 43 cellular cellular JJ cord-015021-pol2qm74 6798 44 immune immune JJ cord-015021-pol2qm74 6798 45 response response NN cord-015021-pol2qm74 6798 46 and and CC cord-015021-pol2qm74 6798 47 IL-2 il-2 NN cord-015021-pol2qm74 6798 48 productiorl productiorl VBZ cord-015021-pol2qm74 6798 49 following follow VBG cord-015021-pol2qm74 6798 50 atlogeneic atlogeneic NNS cord-015021-pol2qm74 6798 51 blood blood NN cord-015021-pol2qm74 6798 52 transfusion transfusion NN cord-015021-pol2qm74 6798 53 may may MD cord-015021-pol2qm74 6798 54 be be VB cord-015021-pol2qm74 6798 55 mediated mediate VBN cord-015021-pol2qm74 6798 56 by by IN cord-015021-pol2qm74 6798 57 increased increase VBN cord-015021-pol2qm74 6798 58 prostaglandin prostaglandin NN cord-015021-pol2qm74 6798 59 E2 E2 NNP cord-015021-pol2qm74 6798 60 secretion secretion NN cord-015021-pol2qm74 6798 61 , , , cord-015021-pol2qm74 6798 62 and and CC cord-015021-pol2qm74 6798 63 that that IN cord-015021-pol2qm74 6798 64 immune immune JJ cord-015021-pol2qm74 6798 65 response response NN cord-015021-pol2qm74 6798 66 may may MD cord-015021-pol2qm74 6798 67 be be VB cord-015021-pol2qm74 6798 68 preserved preserve VBN cord-015021-pol2qm74 6798 69 in in IN cord-015021-pol2qm74 6798 70 allogeneio allogeneio NNS cord-015021-pol2qm74 6798 71 whole whole JJ cord-015021-pol2qm74 6798 72 blood blood NN cord-015021-pol2qm74 6798 73 transfused transfuse VBN cord-015021-pol2qm74 6798 74 subjects subject NNS cord-015021-pol2qm74 6798 75 receiving receive VBG cord-015021-pol2qm74 6798 76 c3Lc c3lc XX cord-015021-pol2qm74 6798 77 ~ ~ CD cord-015021-pol2qm74 6798 78 oxygenase oxygenase NN cord-015021-pol2qm74 6798 79 inhibitors inhibitor NNS cord-015021-pol2qm74 6798 80 such such JJ cord-015021-pol2qm74 6798 81 as as IN cord-015021-pol2qm74 6798 82 ibuprofen ibuprofen NN cord-015021-pol2qm74 6798 83 . . . cord-015021-pol2qm74 6799 1 Among among IN cord-015021-pol2qm74 6799 2 these these DT cord-015021-pol2qm74 6799 3 are be VBP cord-015021-pol2qm74 6799 4 various various JJ cord-015021-pol2qm74 6799 5 alterations alteration NNS cord-015021-pol2qm74 6799 6 in in IN cord-015021-pol2qm74 6799 7 immune immune JJ cord-015021-pol2qm74 6799 8 function function NN cord-015021-pol2qm74 6799 9 . . . cord-015021-pol2qm74 6800 1 Efforts effort NNS cord-015021-pol2qm74 6800 2 have have VBP cord-015021-pol2qm74 6800 3 therefore therefore RB cord-015021-pol2qm74 6800 4 been be VBN cord-015021-pol2qm74 6800 5 made make VBN cord-015021-pol2qm74 6800 6 to to TO cord-015021-pol2qm74 6800 7 utilize utilize VB cord-015021-pol2qm74 6800 8 alternatives alternative NNS cord-015021-pol2qm74 6800 9 to to IN cord-015021-pol2qm74 6800 10 homologous homologous JJ cord-015021-pol2qm74 6800 11 transfusions transfusion NNS cord-015021-pol2qm74 6800 12 . . . cord-015021-pol2qm74 6801 1 These these DT cord-015021-pol2qm74 6801 2 include include VBP cord-015021-pol2qm74 6801 3 the the DT cord-015021-pol2qm74 6801 4 use use NN cord-015021-pol2qm74 6801 5 of of IN cord-015021-pol2qm74 6801 6 autologous autologous JJ cord-015021-pol2qm74 6801 7 predonation predonation NN cord-015021-pol2qm74 6801 8 , , , cord-015021-pol2qm74 6801 9 supplemental supplemental JJ cord-015021-pol2qm74 6801 10 iron iron NN cord-015021-pol2qm74 6801 11 therapy therapy NN cord-015021-pol2qm74 6801 12 , , , cord-015021-pol2qm74 6801 13 and and CC cord-015021-pol2qm74 6801 14 recombinant recombinant JJ cord-015021-pol2qm74 6801 15 human human JJ cord-015021-pol2qm74 6801 16 erythropoietin erythropoietin NN cord-015021-pol2qm74 6801 17 . . . cord-015021-pol2qm74 6802 1 Although although IN cord-015021-pol2qm74 6802 2 initially initially RB cord-015021-pol2qm74 6802 3 considered consider VBN cord-015021-pol2qm74 6802 4 innocuous innocuous JJ cord-015021-pol2qm74 6802 5 , , , cord-015021-pol2qm74 6802 6 these these DT cord-015021-pol2qm74 6802 7 therapies therapy NNS cord-015021-pol2qm74 6802 8 are be VBP cord-015021-pol2qm74 6802 9 now now RB cord-015021-pol2qm74 6802 10 recognized recognize VBN cord-015021-pol2qm74 6802 11 to to TO cord-015021-pol2qm74 6802 12 have have VB cord-015021-pol2qm74 6802 13 potential potential JJ cord-015021-pol2qm74 6802 14 deliterious deliterious JJ cord-015021-pol2qm74 6802 15 immune immune JJ cord-015021-pol2qm74 6802 16 sequelae sequela NNS cord-015021-pol2qm74 6802 17 . . . cord-015021-pol2qm74 6803 1 Erythropoietin erythropoietin NN cord-015021-pol2qm74 6803 2 , , , cord-015021-pol2qm74 6803 3 by by IN cord-015021-pol2qm74 6803 4 its -PRON- PRP$ cord-015021-pol2qm74 6803 5 ability ability NN cord-015021-pol2qm74 6803 6 to to TO cord-015021-pol2qm74 6803 7 lower lower VB cord-015021-pol2qm74 6803 8 serum serum NN cord-015021-pol2qm74 6803 9 iron iron NN cord-015021-pol2qm74 6803 10 levels level NNS cord-015021-pol2qm74 6803 11 , , , cord-015021-pol2qm74 6803 12 can can MD cord-015021-pol2qm74 6803 13 impair impair VB cord-015021-pol2qm74 6803 14 both both DT cord-015021-pol2qm74 6803 15 lymphocyte lymphocyte NN cord-015021-pol2qm74 6803 16 and and CC cord-015021-pol2qm74 6803 17 NK NK NNP cord-015021-pol2qm74 6803 18 cell cell NN cord-015021-pol2qm74 6803 19 activity activity NN cord-015021-pol2qm74 6803 20 . . . cord-015021-pol2qm74 6804 1 Autologous autologous JJ cord-015021-pol2qm74 6804 2 donation donation NN cord-015021-pol2qm74 6804 3 impairs impair VBZ cord-015021-pol2qm74 6804 4 NK NK NNP cord-015021-pol2qm74 6804 5 cell cell NN cord-015021-pol2qm74 6804 6 function function NN cord-015021-pol2qm74 6804 7 . . . cord-015021-pol2qm74 6805 1 Finally finally RB cord-015021-pol2qm74 6805 2 , , , cord-015021-pol2qm74 6805 3 supplemental supplemental JJ cord-015021-pol2qm74 6805 4 iron iron NN cord-015021-pol2qm74 6805 5 therapy therapy NN cord-015021-pol2qm74 6805 6 can can MD cord-015021-pol2qm74 6805 7 stimulate stimulate VB cord-015021-pol2qm74 6805 8 bacterial bacterial JJ cord-015021-pol2qm74 6805 9 growth growth NN cord-015021-pol2qm74 6805 10 and and CC cord-015021-pol2qm74 6805 11 increase increase VB cord-015021-pol2qm74 6805 12 the the DT cord-015021-pol2qm74 6805 13 rate rate NN cord-015021-pol2qm74 6805 14 of of IN cord-015021-pol2qm74 6805 15 infectious infectious JJ cord-015021-pol2qm74 6805 16 complications complication NNS cord-015021-pol2qm74 6805 17 . . . cord-015021-pol2qm74 6806 1 This this DT cord-015021-pol2qm74 6806 2 talk talk NN cord-015021-pol2qm74 6806 3 will will MD cord-015021-pol2qm74 6806 4 present present VB cord-015021-pol2qm74 6806 5 a a DT cord-015021-pol2qm74 6806 6 discussion discussion NN cord-015021-pol2qm74 6806 7 of of IN cord-015021-pol2qm74 6806 8 these these DT cord-015021-pol2qm74 6806 9 factors factor NNS cord-015021-pol2qm74 6806 10 as as RB cord-015021-pol2qm74 6806 11 well well RB cord-015021-pol2qm74 6806 12 as as IN cord-015021-pol2qm74 6806 13 a a DT cord-015021-pol2qm74 6806 14 weighting weighting NN cord-015021-pol2qm74 6806 15 of of IN cord-015021-pol2qm74 6806 16 their -PRON- PRP$ cord-015021-pol2qm74 6806 17 importance importance NN cord-015021-pol2qm74 6806 18 . . . cord-015021-pol2qm74 6807 1 R.L R.L NNP cord-015021-pol2qm74 6807 2 Rutan Rutan NNP cord-015021-pol2qm74 6807 3 , , , cord-015021-pol2qm74 6807 4 RN;BSN RN;BSN NNP cord-015021-pol2qm74 6807 5 , , , cord-015021-pol2qm74 6807 6 Shriners Shriners NNP cord-015021-pol2qm74 6807 7 Burns Burns NNP cord-015021-pol2qm74 6807 8 Institute Institute NNP cord-015021-pol2qm74 6807 9 and and CC cord-015021-pol2qm74 6807 10 The the DT cord-015021-pol2qm74 6807 11 University University NNP cord-015021-pol2qm74 6807 12 of of IN cord-015021-pol2qm74 6807 13 Texas Texas NNP cord-015021-pol2qm74 6807 14 Medical Medical NNP cord-015021-pol2qm74 6807 15 Branch Branch NNP cord-015021-pol2qm74 6807 16 , , , cord-015021-pol2qm74 6807 17 Galveston Galveston NNP cord-015021-pol2qm74 6807 18 TX TX NNP cord-015021-pol2qm74 6807 19 , , , cord-015021-pol2qm74 6807 20 USA USA NNP cord-015021-pol2qm74 6808 1 The the DT cord-015021-pol2qm74 6808 2 serious serious JJ cord-015021-pol2qm74 6808 3 sequelae sequela NNS cord-015021-pol2qm74 6808 4 of of IN cord-015021-pol2qm74 6808 5 homologous homologous JJ cord-015021-pol2qm74 6808 6 blood blood NN cord-015021-pol2qm74 6808 7 transfusions transfusion NNS cord-015021-pol2qm74 6808 8 have have VBP cord-015021-pol2qm74 6808 9 resulted result VBN cord-015021-pol2qm74 6808 10 in in IN cord-015021-pol2qm74 6808 11 vigorous vigorous JJ cord-015021-pol2qm74 6808 12 efforts effort NNS cord-015021-pol2qm74 6808 13 at at IN cord-015021-pol2qm74 6808 14 identifying identify VBG cord-015021-pol2qm74 6808 15 alternate alternate JJ cord-015021-pol2qm74 6808 16 therapies therapy NNS cord-015021-pol2qm74 6808 17 for for IN cord-015021-pol2qm74 6808 18 correcting correct VBG cord-015021-pol2qm74 6808 19 red red JJ cord-015021-pol2qm74 6808 20 blood blood NN cord-015021-pol2qm74 6808 21 cell cell NN cord-015021-pol2qm74 6808 22 ( ( -LRB- cord-015021-pol2qm74 6808 23 RBC RBC NNP cord-015021-pol2qm74 6808 24 ) ) -RRB- cord-015021-pol2qm74 6808 25 deficits deficit NNS cord-015021-pol2qm74 6808 26 . . . cord-015021-pol2qm74 6809 1 Erythropoietin Erythropoietin NNP cord-015021-pol2qm74 6809 2 ( ( -LRB- cord-015021-pol2qm74 6809 3 EPO EPO NNP cord-015021-pol2qm74 6809 4 ) ) -RRB- cord-015021-pol2qm74 6809 5 was be VBD cord-015021-pol2qm74 6809 6 hypothesized hypothesize VBN cord-015021-pol2qm74 6809 7 to to TO cord-015021-pol2qm74 6809 8 exist exist VB cord-015021-pol2qm74 6809 9 in in IN cord-015021-pol2qm74 6809 10 the the DT cord-015021-pol2qm74 6809 11 early early JJ cord-015021-pol2qm74 6809 12 20th 20th JJ cord-015021-pol2qm74 6809 13 century century NN cord-015021-pol2qm74 6809 14 , , , cord-015021-pol2qm74 6809 15 however however RB cord-015021-pol2qm74 6809 16 the the DT cord-015021-pol2qm74 6809 17 protein protein NN cord-015021-pol2qm74 6809 18 was be VBD cord-015021-pol2qm74 6809 19 not not RB cord-015021-pol2qm74 6809 20 isolaled isolale VBN cord-015021-pol2qm74 6809 21 until until IN cord-015021-pol2qm74 6809 22 1977 1977 CD cord-015021-pol2qm74 6809 23 . . . cord-015021-pol2qm74 6810 1 The the DT cord-015021-pol2qm74 6810 2 human human JJ cord-015021-pol2qm74 6810 3 gene gene NN cord-015021-pol2qm74 6810 4 was be VBD cord-015021-pol2qm74 6810 5 identified identify VBN cord-015021-pol2qm74 6810 6 and and CC cord-015021-pol2qm74 6810 7 cloned clone VBN cord-015021-pol2qm74 6810 8 in in IN cord-015021-pol2qm74 6810 9 1983 1983 CD cord-015021-pol2qm74 6810 10 , , , cord-015021-pol2qm74 6810 11 which which WDT cord-015021-pol2qm74 6810 12 permitted permit VBD cord-015021-pol2qm74 6810 13 the the DT cord-015021-pol2qm74 6810 14 production production NN cord-015021-pol2qm74 6810 15 of of IN cord-015021-pol2qm74 6810 16 EPO EPO NNP cord-015021-pol2qm74 6810 17 through through IN cord-015021-pol2qm74 6810 18 recombinant recombinant JJ cord-015021-pol2qm74 6810 19 techniques technique NNS cord-015021-pol2qm74 6810 20 . . . cord-015021-pol2qm74 6811 1 The the DT cord-015021-pol2qm74 6811 2 earliest early JJS cord-015021-pol2qm74 6811 3 clinical clinical JJ cord-015021-pol2qm74 6811 4 trials trial NNS cord-015021-pol2qm74 6811 5 were be VBD cord-015021-pol2qm74 6811 6 performed perform VBN cord-015021-pol2qm74 6811 7 in in IN cord-015021-pol2qm74 6811 8 anemic anemic JJ cord-015021-pol2qm74 6811 9 end end JJ cord-015021-pol2qm74 6811 10 - - HYPH cord-015021-pol2qm74 6811 11 stage stage NN cord-015021-pol2qm74 6811 12 renal renal JJ cord-015021-pol2qm74 6811 13 failure failure NN cord-015021-pol2qm74 6811 14 palients palient NNS cord-015021-pol2qm74 6811 15 on on IN cord-015021-pol2qm74 6811 16 hemodialysis hemodialysis NN cord-015021-pol2qm74 6811 17 . . . cord-015021-pol2qm74 6812 1 Treated treat VBN cord-015021-pol2qm74 6812 2 patients patient NNS cord-015021-pol2qm74 6812 3 experienced experience VBD cord-015021-pol2qm74 6812 4 increases increase NNS cord-015021-pol2qm74 6812 5 in in IN cord-015021-pol2qm74 6812 6 erythropoiesis erythropoiesis NN cord-015021-pol2qm74 6812 7 with with IN cord-015021-pol2qm74 6812 8 normalization normalization NN cord-015021-pol2qm74 6812 9 of of IN cord-015021-pol2qm74 6812 10 hematocrit hematocrit NN cord-015021-pol2qm74 6812 11 and and CC cord-015021-pol2qm74 6812 12 hemoglobin hemoglobin NN cord-015021-pol2qm74 6812 13 levels level NNS cord-015021-pol2qm74 6812 14 , , , cord-015021-pol2qm74 6812 15 cessation cessation NN cord-015021-pol2qm74 6812 16 of of IN cord-015021-pol2qm74 6812 17 lrans lran NNS cord-015021-pol2qm74 6812 18 - - HYPH cord-015021-pol2qm74 6812 19 fusion fusion NN cord-015021-pol2qm74 6812 20 requirements requirement NNS cord-015021-pol2qm74 6812 21 and and CC cord-015021-pol2qm74 6812 22 improvement improvement NN cord-015021-pol2qm74 6812 23 in in IN cord-015021-pol2qm74 6812 24 general general JJ cord-015021-pol2qm74 6812 25 wellbeing wellbeing NN cord-015021-pol2qm74 6812 26 . . . cord-015021-pol2qm74 6813 1 These these DT cord-015021-pol2qm74 6813 2 studies study NNS cord-015021-pol2qm74 6813 3 , , , cord-015021-pol2qm74 6813 4 however however RB cord-015021-pol2qm74 6813 5 , , , cord-015021-pol2qm74 6813 6 identified identify VBD cord-015021-pol2qm74 6813 7 side side NN cord-015021-pol2qm74 6813 8 effects effect NNS cord-015021-pol2qm74 6813 9 of of IN cord-015021-pol2qm74 6813 10 EPO EPO NNP cord-015021-pol2qm74 6813 11 treatment treatment NN cord-015021-pol2qm74 6813 12 such such JJ cord-015021-pol2qm74 6813 13 as as IN cord-015021-pol2qm74 6813 14 hypertension hypertension NN cord-015021-pol2qm74 6813 15 , , , cord-015021-pol2qm74 6813 16 seizures seizure NNS cord-015021-pol2qm74 6813 17 and and CC cord-015021-pol2qm74 6813 18 Ee Ee NNP cord-015021-pol2qm74 6813 19 deficiency deficiency NN cord-015021-pol2qm74 6813 20 . . . cord-015021-pol2qm74 6814 1 Volunteer volunteer NN cord-015021-pol2qm74 6814 2 trials trial NNS cord-015021-pol2qm74 6814 3 have have VBP cord-015021-pol2qm74 6814 4 established establish VBN cord-015021-pol2qm74 6814 5 that that IN cord-015021-pol2qm74 6814 6 the the DT cord-015021-pol2qm74 6814 7 hypertension hypertension NN cord-015021-pol2qm74 6814 8 is be VBZ cord-015021-pol2qm74 6814 9 not not RB cord-015021-pol2qm74 6814 10 a a DT cord-015021-pol2qm74 6814 11 direct direct JJ cord-015021-pol2qm74 6814 12 pressor pressor NN cord-015021-pol2qm74 6814 13 effect effect NN cord-015021-pol2qm74 6814 14 but but CC cord-015021-pol2qm74 6814 15 rather rather RB cord-015021-pol2qm74 6814 16 the the DT cord-015021-pol2qm74 6814 17 result result NN cord-015021-pol2qm74 6814 18 of of IN cord-015021-pol2qm74 6814 19 abnormally abnormally RB cord-015021-pol2qm74 6814 20 rapid rapid JJ cord-015021-pol2qm74 6814 21 increases increase NNS cord-015021-pol2qm74 6814 22 in in IN cord-015021-pol2qm74 6814 23 red red JJ cord-015021-pol2qm74 6814 24 cell cell NN cord-015021-pol2qm74 6814 25 mass mass NN cord-015021-pol2qm74 6814 26 in in IN cord-015021-pol2qm74 6814 27 the the DT cord-015021-pol2qm74 6814 28 face face NN cord-015021-pol2qm74 6814 29 of of IN cord-015021-pol2qm74 6814 30 the the DT cord-015021-pol2qm74 6814 31 incompetent incompetent JJ cord-015021-pol2qm74 6814 32 volume volume NN cord-015021-pol2qm74 6814 33 - - HYPH cord-015021-pol2qm74 6814 34 controlling control VBG cord-015021-pol2qm74 6814 35 mechanisms mechanism NNS cord-015021-pol2qm74 6814 36 of of IN cord-015021-pol2qm74 6814 37 the the DT cord-015021-pol2qm74 6814 38 end end NN cord-015021-pol2qm74 6814 39 stage stage NN cord-015021-pol2qm74 6814 40 renal renal JJ cord-015021-pol2qm74 6814 41 failure failure NN cord-015021-pol2qm74 6814 42 patient patient NN cord-015021-pol2qm74 6814 43 . . . cord-015021-pol2qm74 6815 1 Lower low JJR cord-015021-pol2qm74 6815 2 doses dose NNS cord-015021-pol2qm74 6815 3 of of IN cord-015021-pol2qm74 6815 4 EPO EPO NNP cord-015021-pol2qm74 6815 5 and and CC cord-015021-pol2qm74 6815 6 the the DT cord-015021-pol2qm74 6815 7 subsequent subsequent JJ cord-015021-pol2qm74 6815 8 gradual gradual JJ cord-015021-pol2qm74 6815 9 increases increase NNS cord-015021-pol2qm74 6815 10 in in IN cord-015021-pol2qm74 6815 11 red red JJ cord-015021-pol2qm74 6815 12 cell cell NN cord-015021-pol2qm74 6815 13 mass mass NN cord-015021-pol2qm74 6815 14 are be VBP cord-015021-pol2qm74 6815 15 associated associate VBN cord-015021-pol2qm74 6815 16 with with IN cord-015021-pol2qm74 6815 17 significantly significantly RB cord-015021-pol2qm74 6815 18 lower low JJR cord-015021-pol2qm74 6815 19 incidences incidence NNS cord-015021-pol2qm74 6815 20 of of IN cord-015021-pol2qm74 6815 21 hypertensive hypertensive JJ cord-015021-pol2qm74 6815 22 complications complication NNS cord-015021-pol2qm74 6815 23 of of IN cord-015021-pol2qm74 6815 24 EPO EPO NNP cord-015021-pol2qm74 6815 25 therapy therapy NN cord-015021-pol2qm74 6815 26 . . . cord-015021-pol2qm74 6816 1 Likewise likewise RB cord-015021-pol2qm74 6816 2 , , , cord-015021-pol2qm74 6816 3 seizure seizure NN cord-015021-pol2qm74 6816 4 activity activity NN cord-015021-pol2qm74 6816 5 is be VBZ cord-015021-pol2qm74 6816 6 not not RB cord-015021-pol2qm74 6816 7 the the DT cord-015021-pol2qm74 6816 8 result result NN cord-015021-pol2qm74 6816 9 of of IN cord-015021-pol2qm74 6816 10 a a DT cord-015021-pol2qm74 6816 11 direct direct JJ cord-015021-pol2qm74 6816 12 epileptogenie epileptogenie NN cord-015021-pol2qm74 6816 13 effect effect NN cord-015021-pol2qm74 6816 14 but but CC cord-015021-pol2qm74 6816 15 parallels parallel VBZ cord-015021-pol2qm74 6816 16 the the DT cord-015021-pol2qm74 6816 17 incidence incidence NN cord-015021-pol2qm74 6816 18 of of IN cord-015021-pol2qm74 6816 19 hyper hyper JJ cord-015021-pol2qm74 6816 20 - - JJ cord-015021-pol2qm74 6816 21 tensive tensive JJ cord-015021-pol2qm74 6816 22 - - HYPH cord-015021-pol2qm74 6816 23 related relate VBN cord-015021-pol2qm74 6816 24 sequelae sequela NNS cord-015021-pol2qm74 6816 25 during during IN cord-015021-pol2qm74 6816 26 high.dose high.dose NNP cord-015021-pol2qm74 6816 27 EPO EPO NNP cord-015021-pol2qm74 6816 28 treatment treatment NN cord-015021-pol2qm74 6816 29 . . . cord-015021-pol2qm74 6817 1 In in IN cord-015021-pol2qm74 6817 2 cross cross JJ cord-015021-pol2qm74 6817 3 - - HYPH cord-015021-pol2qm74 6817 4 over over RP cord-015021-pol2qm74 6817 5 designed design VBN cord-015021-pol2qm74 6817 6 studies study NNS cord-015021-pol2qm74 6817 7 , , , cord-015021-pol2qm74 6817 8 pre pre VBN cord-015021-pol2qm74 6817 9 - - JJ cord-015021-pol2qm74 6817 10 existing existing JJ cord-015021-pol2qm74 6817 11 iron iron NN cord-015021-pol2qm74 6817 12 deficiency deficiency NN cord-015021-pol2qm74 6817 13 has have VBZ cord-015021-pol2qm74 6817 14 been be VBN cord-015021-pol2qm74 6817 15 demonstrated demonstrate VBN cord-015021-pol2qm74 6817 16 to to TO cord-015021-pol2qm74 6817 17 decrease decrease VB cord-015021-pol2qm74 6817 18 or or CC cord-015021-pol2qm74 6817 19 negate negate VB cord-015021-pol2qm74 6817 20 stimulated stimulate VBN cord-015021-pol2qm74 6817 21 erythropoiesis erythropoiesis NN cord-015021-pol2qm74 6817 22 but but CC cord-015021-pol2qm74 6817 23 effective effective JJ cord-015021-pol2qm74 6817 24 - - : cord-015021-pol2qm74 6817 25 hess hess NNP cord-015021-pol2qm74 6817 26 can can MD cord-015021-pol2qm74 6817 27 be be VB cord-015021-pol2qm74 6817 28 restored restore VBN cord-015021-pol2qm74 6817 29 with with IN cord-015021-pol2qm74 6817 30 appropriate appropriate JJ cord-015021-pol2qm74 6817 31 Fe Fe NNP cord-015021-pol2qm74 6817 32 supplementation supplementation NN cord-015021-pol2qm74 6817 33 . . . cord-015021-pol2qm74 6818 1 Exogenous exogenous JJ cord-015021-pol2qm74 6818 2 EPO EPO NNP cord-015021-pol2qm74 6818 3 is be VBZ cord-015021-pol2qm74 6818 4 effective effective JJ cord-015021-pol2qm74 6818 5 whether whether IN cord-015021-pol2qm74 6818 6 given give VBN cord-015021-pol2qm74 6818 7 by by IN cord-015021-pol2qm74 6818 8 IV IV NNP cord-015021-pol2qm74 6818 9 or or CC cord-015021-pol2qm74 6818 10 SQ SQ NNP cord-015021-pol2qm74 6818 11 routes route NNS cord-015021-pol2qm74 6818 12 and and CC cord-015021-pol2qm74 6818 13 dose dose NN cord-015021-pol2qm74 6818 14 response response NN cord-015021-pol2qm74 6818 15 curves curve NNS cord-015021-pol2qm74 6818 16 do do VBP cord-015021-pol2qm74 6818 17 not not RB cord-015021-pol2qm74 6818 18 vary vary VB cord-015021-pol2qm74 6818 19 with with IN cord-015021-pol2qm74 6818 20 route route NN cord-015021-pol2qm74 6818 21 of of IN cord-015021-pol2qm74 6818 22 administration administration NN cord-015021-pol2qm74 6818 23 . . . cord-015021-pol2qm74 6819 1 Increases increase NNS cord-015021-pol2qm74 6819 2 in in IN cord-015021-pol2qm74 6819 3 RBC RBC NNP cord-015021-pol2qm74 6819 4 mass mass NN cord-015021-pol2qm74 6819 5 are be VBP cord-015021-pol2qm74 6819 6 directly directly RB cord-015021-pol2qm74 6819 7 related relate VBN cord-015021-pol2qm74 6819 8 to to IN cord-015021-pol2qm74 6819 9 the the DT cord-015021-pol2qm74 6819 10 dose dose NN cord-015021-pol2qm74 6819 11 of of IN cord-015021-pol2qm74 6819 12 EPO EPO NNP cord-015021-pol2qm74 6819 13 , , , cord-015021-pol2qm74 6819 14 both both CC cord-015021-pol2qm74 6819 15 in in IN cord-015021-pol2qm74 6819 16 amount amount NN cord-015021-pol2qm74 6819 17 and and CC cord-015021-pol2qm74 6819 18 frequency frequency NN cord-015021-pol2qm74 6819 19 of of IN cord-015021-pol2qm74 6819 20 administration administration NN cord-015021-pol2qm74 6819 21 although although IN cord-015021-pol2qm74 6819 22 there there EX cord-015021-pol2qm74 6819 23 is be VBZ cord-015021-pol2qm74 6819 24 a a DT cord-015021-pol2qm74 6819 25 3 3 CD cord-015021-pol2qm74 6819 26 - - SYM cord-015021-pol2qm74 6819 27 5 5 CD cord-015021-pol2qm74 6819 28 day day NN cord-015021-pol2qm74 6819 29 time time NN cord-015021-pol2qm74 6819 30 lag lag VB cord-015021-pol2qm74 6819 31 between between IN cord-015021-pol2qm74 6819 32 the the DT cord-015021-pol2qm74 6819 33 first first JJ cord-015021-pol2qm74 6819 34 EPO EPO NNP cord-015021-pol2qm74 6819 35 dose dose NN cord-015021-pol2qm74 6819 36 and and CC cord-015021-pol2qm74 6819 37 laboratory laboratory NN cord-015021-pol2qm74 6819 38 indications indication NNS cord-015021-pol2qm74 6819 39 of of IN cord-015021-pol2qm74 6819 40 its -PRON- PRP$ cord-015021-pol2qm74 6819 41 action action NN cord-015021-pol2qm74 6819 42 ( ( -LRB- cord-015021-pol2qm74 6819 43 i.e. i.e. FW cord-015021-pol2qm74 6819 44 increase increase NN cord-015021-pol2qm74 6819 45 in in IN cord-015021-pol2qm74 6819 46 the the DT cord-015021-pol2qm74 6819 47 number number NN cord-015021-pol2qm74 6819 48 of of IN cord-015021-pol2qm74 6819 49 reticulceytes reticulceyte NNS cord-015021-pol2qm74 6819 50 in in IN cord-015021-pol2qm74 6819 51 peripheral peripheral JJ cord-015021-pol2qm74 6819 52 Wood Wood NNP cord-015021-pol2qm74 6819 53 ) ) -RRB- cord-015021-pol2qm74 6819 54 . . . cord-015021-pol2qm74 6820 1 EPO EPO NNP cord-015021-pol2qm74 6820 2 is be VBZ cord-015021-pol2qm74 6820 3 currently currently RB cord-015021-pol2qm74 6820 4 labelled label VBN cord-015021-pol2qm74 6820 5 for for IN cord-015021-pol2qm74 6820 6 use use NN cord-015021-pol2qm74 6820 7 in in IN cord-015021-pol2qm74 6820 8 the the DT cord-015021-pol2qm74 6820 9 treatment treatment NN cord-015021-pol2qm74 6820 10 of of IN cord-015021-pol2qm74 6820 11 anemias anemia NNS cord-015021-pol2qm74 6820 12 associated associate VBN cord-015021-pol2qm74 6820 13 with with IN cord-015021-pol2qm74 6820 14 end end NN cord-015021-pol2qm74 6820 15 - - HYPH cord-015021-pol2qm74 6820 16 stage stage NN cord-015021-pol2qm74 6820 17 renal renal JJ cord-015021-pol2qm74 6820 18 disease disease NN cord-015021-pol2qm74 6820 19 and and CC cord-015021-pol2qm74 6820 20 AIDS AIDS NNP cord-015021-pol2qm74 6820 21 . . . cord-015021-pol2qm74 6821 1 However however RB cord-015021-pol2qm74 6821 2 , , , cord-015021-pol2qm74 6821 3 its -PRON- PRP$ cord-015021-pol2qm74 6821 4 use use NN cord-015021-pol2qm74 6821 5 in in IN cord-015021-pol2qm74 6821 6 the the DT cord-015021-pol2qm74 6821 7 surgical surgical JJ cord-015021-pol2qm74 6821 8 population population NN cord-015021-pol2qm74 6821 9 has have VBZ cord-015021-pol2qm74 6821 10 been be VBN cord-015021-pol2qm74 6821 11 explored explore VBN cord-015021-pol2qm74 6821 12 because because IN cord-015021-pol2qm74 6821 13 of of IN cord-015021-pol2qm74 6821 14 its -PRON- PRP$ cord-015021-pol2qm74 6821 15 unique unique JJ cord-015021-pol2qm74 6821 16 direct direct JJ cord-015021-pol2qm74 6821 17 dose dose NN cord-015021-pol2qm74 6821 18 - - HYPH cord-015021-pol2qm74 6821 19 response response NN cord-015021-pol2qm74 6821 20 , , , cord-015021-pol2qm74 6821 21 EPO EPO NNP cord-015021-pol2qm74 6821 22 has have VBZ cord-015021-pol2qm74 6821 23 been be VBN cord-015021-pol2qm74 6821 24 used use VBN cord-015021-pol2qm74 6821 25 to to TO cord-015021-pol2qm74 6821 26 effectively effectively RB cord-015021-pol2qm74 6821 27 increase increase VB cord-015021-pol2qm74 6821 28 the the DT cord-015021-pol2qm74 6821 29 blood blood NN cord-015021-pol2qm74 6821 30 harvest harvest NN cord-015021-pol2qm74 6821 31 amounls amounls NN cord-015021-pol2qm74 6821 32 in in IN cord-015021-pol2qm74 6821 33 autologous autologous JJ cord-015021-pol2qm74 6821 34 pre pre JJ cord-015021-pol2qm74 6821 35 - - NN cord-015021-pol2qm74 6821 36 donation donation NN cord-015021-pol2qm74 6821 37 , , , cord-015021-pol2qm74 6821 38 significantly significantly RB cord-015021-pol2qm74 6821 39 increase increase VBP cord-015021-pol2qm74 6821 40 hematocrils hematocril NNS cord-015021-pol2qm74 6821 41 in in IN cord-015021-pol2qm74 6821 42 children child NNS cord-015021-pol2qm74 6821 43 following follow VBG cord-015021-pol2qm74 6821 44 thermal thermal JJ cord-015021-pol2qm74 6821 45 trauma trauma NN cord-015021-pol2qm74 6821 46 and and CC cord-015021-pol2qm74 6821 47 successfully successfully RB cord-015021-pol2qm74 6821 48 increase increase VB cord-015021-pol2qm74 6821 49 red red JJ cord-015021-pol2qm74 6821 50 blood blood NN cord-015021-pol2qm74 6821 51 cell cell NN cord-015021-pol2qm74 6821 52 mass mass NN cord-015021-pol2qm74 6821 53 following follow VBG cord-015021-pol2qm74 6821 54 essential essential JJ cord-015021-pol2qm74 6821 55 surgical surgical JJ cord-015021-pol2qm74 6821 56 procedures procedure NNS cord-015021-pol2qm74 6821 57 in in IN cord-015021-pol2qm74 6821 58 patients patient NNS cord-015021-pol2qm74 6821 59 with with IN cord-015021-pol2qm74 6821 60 religious religious JJ cord-015021-pol2qm74 6821 61 aversion aversion NN cord-015021-pol2qm74 6821 62 to to IN cord-015021-pol2qm74 6821 63 transfusion transfusion NN cord-015021-pol2qm74 6821 64 . . . cord-015021-pol2qm74 6822 1 BY by IN cord-015021-pol2qm74 6822 2 BLOOD blood NN cord-015021-pol2qm74 6822 3 TRANSFUSION transfusion NN cord-015021-pol2qm74 6822 4 IN in IN cord-015021-pol2qm74 6822 5 COLORECTAL colorectal JJ cord-015021-pol2qm74 6822 6 CANCER cancer NN cord-015021-pol2qm74 6822 7 SURGERY surgery NN cord-015021-pol2qm74 6823 1 MM MM NNP cord-015021-pol2qm74 6824 1 Heiss Heiss NNP cord-015021-pol2qm74 6824 2 MD MD NNP cord-015021-pol2qm74 6824 3 , , , cord-015021-pol2qm74 6824 4 Ch Ch NNP cord-015021-pol2qm74 6824 5 Delanoff Delanoff NNP cord-015021-pol2qm74 6824 6 MD MD NNP cord-015021-pol2qm74 6824 7 , , , cord-015021-pol2qm74 6824 8 R R NNP cord-015021-pol2qm74 6824 9 Stets Stets NNP cord-015021-pol2qm74 6824 10 MD MD NNP cord-015021-pol2qm74 6824 11 , , , cord-015021-pol2qm74 6824 12 J J NNP cord-015021-pol2qm74 6824 13 Hofinann Hofinann NNP cord-015021-pol2qm74 6824 14 , , , cord-015021-pol2qm74 6824 15 E E NNP cord-015021-pol2qm74 6824 16 Faist Faist NNP cord-015021-pol2qm74 6824 17 MD MD NNP cord-015021-pol2qm74 6824 18 , , , cord-015021-pol2qm74 6824 19 KW KW NNP cord-015021-pol2qm74 6824 20 Jauch Jauch NNP cord-015021-pol2qm74 6824 21 MD MD NNP cord-015021-pol2qm74 6824 22 , , , cord-015021-pol2qm74 6824 23 FW FW NNP cord-015021-pol2qm74 6824 24 Schildberg Schildberg NNP cord-015021-pol2qm74 6824 25 MD MD NNP cord-015021-pol2qm74 6824 26 Allogeneic Allogeneic NNP cord-015021-pol2qm74 6824 27 blood blood NN cord-015021-pol2qm74 6824 28 transfusions transfusion NNS cord-015021-pol2qm74 6824 29 are be VBP cord-015021-pol2qm74 6824 30 associated associate VBN cord-015021-pol2qm74 6824 31 with with IN cord-015021-pol2qm74 6824 32 an an DT cord-015021-pol2qm74 6824 33 increased increase VBN cord-015021-pol2qm74 6824 34 risk risk NN cord-015021-pol2qm74 6824 35 for for IN cord-015021-pol2qm74 6824 36 postoperative postoperative JJ cord-015021-pol2qm74 6824 37 infections infection NNS cord-015021-pol2qm74 6824 38 in in IN cord-015021-pol2qm74 6824 39 colorectal colorectal JJ cord-015021-pol2qm74 6824 40 surgery surgery NN cord-015021-pol2qm74 6824 41 when when WRB cord-015021-pol2qm74 6824 42 compared compare VBN cord-015021-pol2qm74 6824 43 with with IN cord-015021-pol2qm74 6824 44 autologous autologous JJ cord-015021-pol2qm74 6824 45 blood blood NN cord-015021-pol2qm74 6824 46 transfusions transfusion NNS cord-015021-pol2qm74 6824 47 . . . cord-015021-pol2qm74 6825 1 Attribution attribution NN cord-015021-pol2qm74 6825 2 of of IN cord-015021-pol2qm74 6825 3 this this DT cord-015021-pol2qm74 6825 4 effect effect NN cord-015021-pol2qm74 6825 5 to to IN cord-015021-pol2qm74 6825 6 immunomodulation immunomodulation NN cord-015021-pol2qm74 6825 7 was be VBD cord-015021-pol2qm74 6825 8 suspected suspect VBN cord-015021-pol2qm74 6825 9 in in IN cord-015021-pol2qm74 6825 10 our -PRON- PRP$ cord-015021-pol2qm74 6825 11 previous previous JJ cord-015021-pol2qm74 6825 12 study study NN cord-015021-pol2qm74 6825 13 ( ( -LRB- cord-015021-pol2qm74 6825 14 Lancet Lancet NNP cord-015021-pol2qm74 6825 15 1993 1993 CD cord-015021-pol2qm74 6825 16 ; ; : cord-015021-pol2qm74 6825 17 342:1328 342:1328 NNP cord-015021-pol2qm74 6825 18 - - HYPH cord-015021-pol2qm74 6825 19 33 33 CD cord-015021-pol2qm74 6825 20 ) ) -RRB- cord-015021-pol2qm74 6825 21 . . . cord-015021-pol2qm74 6826 1 Task task NN cord-015021-pol2qm74 6826 2 of of IN cord-015021-pol2qm74 6826 3 the the DT cord-015021-pol2qm74 6826 4 recent recent JJ cord-015021-pol2qm74 6826 5 investigations investigation NNS cord-015021-pol2qm74 6826 6 was be VBD cord-015021-pol2qm74 6826 7 to to TO cord-015021-pol2qm74 6826 8 analyze analyze VB cord-015021-pol2qm74 6826 9 which which WDT cord-015021-pol2qm74 6826 10 specific specific JJ cord-015021-pol2qm74 6826 11 effector effector NN cord-015021-pol2qm74 6826 12 systems system NNS cord-015021-pol2qm74 6826 13 were be VBD cord-015021-pol2qm74 6826 14 affected affect VBN cord-015021-pol2qm74 6826 15 in in IN cord-015021-pol2qm74 6826 16 - - HYPH cord-015021-pol2qm74 6826 17 vivo vivo NN cord-015021-pol2qm74 6826 18 by by IN cord-015021-pol2qm74 6826 19 this this DT cord-015021-pol2qm74 6826 20 transfusion transfusion NN cord-015021-pol2qm74 6826 21 - - HYPH cord-015021-pol2qm74 6826 22 associated associate VBN cord-015021-pol2qm74 6826 23 modulation modulation NN cord-015021-pol2qm74 6826 24 . . . cord-015021-pol2qm74 6827 1 For for IN cord-015021-pol2qm74 6827 2 global global JJ cord-015021-pol2qm74 6827 3 in in IN cord-015021-pol2qm74 6827 4 - - HYPH cord-015021-pol2qm74 6827 5 viva viva FW cord-015021-pol2qm74 6827 6 assessment assessment NN cord-015021-pol2qm74 6827 7 of of IN cord-015021-pol2qm74 6827 8 cell cell NN cord-015021-pol2qm74 6827 9 - - HYPH cord-015021-pol2qm74 6827 10 mediated mediate VBN cord-015021-pol2qm74 6827 11 immunity immunity NN cord-015021-pol2qm74 6827 12 ( ( -LRB- cord-015021-pol2qm74 6827 13 CMI CMI NNP cord-015021-pol2qm74 6827 14 ) ) -RRB- cord-015021-pol2qm74 6828 1 multiple multiple JJ cord-015021-pol2qm74 6828 2 recall recall NN cord-015021-pol2qm74 6829 1 skin skin NN cord-015021-pol2qm74 6829 2 - - HYPH cord-015021-pol2qm74 6829 3 reactions reaction NNS cord-015021-pol2qm74 6829 4 were be VBD cord-015021-pol2qm74 6829 5 applied apply VBN cord-015021-pol2qm74 6829 6 prior prior RB cord-015021-pol2qm74 6829 7 and and CC cord-015021-pol2qm74 6829 8 post post JJ cord-015021-pol2qm74 6829 9 - - JJ cord-015021-pol2qm74 6829 10 operative operative JJ cord-015021-pol2qm74 6829 11 . . . cord-015021-pol2qm74 6830 1 The the DT cord-015021-pol2qm74 6830 2 specific specific JJ cord-015021-pol2qm74 6830 3 humoral humoral JJ cord-015021-pol2qm74 6830 4 immune immune JJ cord-015021-pol2qm74 6830 5 mechanisms mechanism NNS cord-015021-pol2qm74 6830 6 were be VBD cord-015021-pol2qm74 6830 7 investigated investigate VBN cord-015021-pol2qm74 6830 8 by by IN cord-015021-pol2qm74 6830 9 applying apply VBG cord-015021-pol2qm74 6830 10 Tetanus Tetanus NNP cord-015021-pol2qm74 6830 11 - - HYPH cord-015021-pol2qm74 6830 12 Toxoid Toxoid NNP cord-015021-pol2qm74 6830 13 one one CD cord-015021-pol2qm74 6830 14 day day NN cord-015021-pol2qm74 6830 15 preoperatively preoperatively NN cord-015021-pol2qm74 6830 16 and and CC cord-015021-pol2qm74 6830 17 deterimnating deterimnate VBG cord-015021-pol2qm74 6830 18 the the DT cord-015021-pol2qm74 6830 19 quantitative quantitative JJ cord-015021-pol2qm74 6830 20 IgG igg NN cord-015021-pol2qm74 6830 21 - - HYPH cord-015021-pol2qm74 6830 22 response response NN cord-015021-pol2qm74 6830 23 . . . cord-015021-pol2qm74 6831 1 For for IN cord-015021-pol2qm74 6831 2 indication indication NN cord-015021-pol2qm74 6831 3 of of IN cord-015021-pol2qm74 6831 4 macrophage macrophage NN cord-015021-pol2qm74 6831 5 stimulation stimulation NN cord-015021-pol2qm74 6831 6 in in IN cord-015021-pol2qm74 6831 7 - - HYPH cord-015021-pol2qm74 6831 8 vivo vivo NNP cord-015021-pol2qm74 6831 9 TNF tnf NN cord-015021-pol2qm74 6831 10 - - HYPH cord-015021-pol2qm74 6831 11 levels level NNS cord-015021-pol2qm74 6831 12 were be VBD cord-015021-pol2qm74 6831 13 determinated determinate VBN cord-015021-pol2qm74 6831 14 by by IN cord-015021-pol2qm74 6831 15 bioassay bioassay NN cord-015021-pol2qm74 6831 16 . . . cord-015021-pol2qm74 6832 1 DTH DTH NNP cord-015021-pol2qm74 6832 2 - - HYPH cord-015021-pol2qm74 6832 3 responses response NNS cord-015021-pol2qm74 6832 4 were be VBD cord-015021-pol2qm74 6832 5 significantly significantly RB cord-015021-pol2qm74 6832 6 suppressed suppress VBN cord-015021-pol2qm74 6832 7 ( ( -LRB- cord-015021-pol2qm74 6832 8 p<0.05 p<0.05 CD cord-015021-pol2qm74 6832 9 ) ) -RRB- cord-015021-pol2qm74 6832 10 in in IN cord-015021-pol2qm74 6832 11 patients patient NNS cord-015021-pol2qm74 6832 12 receiving receive VBG cord-015021-pol2qm74 6832 13 allogeneic allogeneic IN cord-015021-pol2qm74 6832 14 blood blood NN cord-015021-pol2qm74 6832 15 ( ( -LRB- cord-015021-pol2qm74 6832 16 n=36 n=36 NNS cord-015021-pol2qm74 6832 17 ) ) -RRB- cord-015021-pol2qm74 6832 18 or or CC cord-015021-pol2qm74 6832 19 operated operate VBN cord-015021-pol2qm74 6832 20 without without IN cord-015021-pol2qm74 6832 21 blood blood NN cord-015021-pol2qm74 6832 22 transfusions transfusion NNS cord-015021-pol2qm74 6832 23 ( ( -LRB- cord-015021-pol2qm74 6832 24 n=17 n=17 NNP cord-015021-pol2qm74 6832 25 ) ) -RRB- cord-015021-pol2qm74 6832 26 . . . cord-015021-pol2qm74 6833 1 DTHresponses DTHresponses NNP cord-015021-pol2qm74 6833 2 were be VBD cord-015021-pol2qm74 6833 3 not not RB cord-015021-pol2qm74 6833 4 suppressed suppress VBN cord-015021-pol2qm74 6833 5 and and CC cord-015021-pol2qm74 6833 6 tendentiously tendentiously RB cord-015021-pol2qm74 6833 7 increased increase VBN cord-015021-pol2qm74 6833 8 in in IN cord-015021-pol2qm74 6833 9 patients patient NNS cord-015021-pol2qm74 6833 10 with with IN cord-015021-pol2qm74 6833 11 autologous autologous JJ cord-015021-pol2qm74 6833 12 blood blood NN cord-015021-pol2qm74 6833 13 transfusions transfusion NNS cord-015021-pol2qm74 6833 14 ( ( -LRB- cord-015021-pol2qm74 6833 15 n=24 n=24 NNP cord-015021-pol2qm74 6833 16 ) ) -RRB- cord-015021-pol2qm74 6833 17 . . . cord-015021-pol2qm74 6834 1 In in IN cord-015021-pol2qm74 6834 2 contrast contrast NN cord-015021-pol2qm74 6834 3 , , , cord-015021-pol2qm74 6834 4 specific specific JJ cord-015021-pol2qm74 6834 5 IgG igg NN cord-015021-pol2qm74 6834 6 - - HYPH cord-015021-pol2qm74 6834 7 levels level NNS cord-015021-pol2qm74 6834 8 increased increase VBN cord-015021-pol2qm74 6834 9 sigmficantly sigmficantly RB cord-015021-pol2qm74 6834 10 ( ( -LRB- cord-015021-pol2qm74 6834 11 p<0.05 p<0.05 CD cord-015021-pol2qm74 6834 12 ) ) -RRB- cord-015021-pol2qm74 6834 13 in in IN cord-015021-pol2qm74 6834 14 patients patient NNS cord-015021-pol2qm74 6834 15 receiving receive VBG cord-015021-pol2qm74 6834 16 allogeneie allogeneie NN cord-015021-pol2qm74 6834 17 blood blood NN cord-015021-pol2qm74 6834 18 ( ( -LRB- cord-015021-pol2qm74 6834 19 from from IN cord-015021-pol2qm74 6834 20 1.6 1.6 CD cord-015021-pol2qm74 6834 21 + + SYM cord-015021-pol2qm74 6834 22 4.4 4.4 CD cord-015021-pol2qm74 6834 23 to to TO cord-015021-pol2qm74 6834 24 9.7 9.7 CD cord-015021-pol2qm74 6834 25 _ _ NN cord-015021-pol2qm74 6834 26 + + SYM cord-015021-pol2qm74 6834 27 18.4 18.4 CD cord-015021-pol2qm74 6834 28 IE IE NNP cord-015021-pol2qm74 6834 29 / / SYM cord-015021-pol2qm74 6834 30 ml ml NN cord-015021-pol2qm74 6834 31 ) ) -RRB- cord-015021-pol2qm74 6834 32 whereas whereas IN cord-015021-pol2qm74 6834 33 in in IN cord-015021-pol2qm74 6834 34 patients patient NNS cord-015021-pol2qm74 6834 35 receiving receive VBG cord-015021-pol2qm74 6834 36 autologous autologous JJ cord-015021-pol2qm74 6834 37 blood blood NN cord-015021-pol2qm74 6834 38 a a DT cord-015021-pol2qm74 6834 39 smaller small JJR cord-015021-pol2qm74 6834 40 increase increase NN cord-015021-pol2qm74 6834 41 ( ( -LRB- cord-015021-pol2qm74 6834 42 from from IN cord-015021-pol2qm74 6834 43 1.9 1.9 CD cord-015021-pol2qm74 6834 44 + + SYM cord-015021-pol2qm74 6834 45 4.1 4.1 CD cord-015021-pol2qm74 6834 46 to to TO cord-015021-pol2qm74 6834 47 4.0 4.0 CD cord-015021-pol2qm74 6834 48 + + SYM cord-015021-pol2qm74 6834 49 6.7 6.7 CD cord-015021-pol2qm74 6834 50 ; ; : cord-015021-pol2qm74 6834 51 p=0.068 p=0.068 NN cord-015021-pol2qm74 6834 52 ) ) -RRB- cord-015021-pol2qm74 6834 53 was be VBD cord-015021-pol2qm74 6834 54 observed observe VBN cord-015021-pol2qm74 6834 55 . . . cord-015021-pol2qm74 6835 1 TNFlevels TNFlevels NNP cord-015021-pol2qm74 6835 2 demonstrated demonstrate VBD cord-015021-pol2qm74 6835 3 a a DT cord-015021-pol2qm74 6835 4 similar similar JJ cord-015021-pol2qm74 6835 5 pattern pattern NN cord-015021-pol2qm74 6835 6 with with IN cord-015021-pol2qm74 6835 7 a a DT cord-015021-pol2qm74 6835 8 higher high JJR cord-015021-pol2qm74 6835 9 increase increase NN cord-015021-pol2qm74 6835 10 in in IN cord-015021-pol2qm74 6835 11 patients patient NNS cord-015021-pol2qm74 6835 12 receiving receive VBG cord-015021-pol2qm74 6835 13 allogeneic allogeneic NN cord-015021-pol2qm74 6835 14 transfusions transfusion NNS cord-015021-pol2qm74 6835 15 ( ( -LRB- cord-015021-pol2qm74 6835 16 l l NN cord-015021-pol2qm74 6835 17 1.4 1.4 CD cord-015021-pol2qm74 6835 18 + + SYM cord-015021-pol2qm74 6835 19 12.0 12.0 CD cord-015021-pol2qm74 6835 20 to to IN cord-015021-pol2qm74 6835 21 28.5 28.5 CD cord-015021-pol2qm74 6835 22 + + SYM cord-015021-pol2qm74 6835 23 11.4 11.4 CD cord-015021-pol2qm74 6835 24 u u NNP cord-015021-pol2qm74 6835 25 / / SYM cord-015021-pol2qm74 6835 26 ml ml NN cord-015021-pol2qm74 6835 27 ) ) -RRB- cord-015021-pol2qm74 6835 28 compared compare VBN cord-015021-pol2qm74 6835 29 to to IN cord-015021-pol2qm74 6835 30 those those DT cord-015021-pol2qm74 6835 31 patients patient NNS cord-015021-pol2qm74 6835 32 with with IN cord-015021-pol2qm74 6835 33 autologous autologous JJ cord-015021-pol2qm74 6835 34 blood blood NN cord-015021-pol2qm74 6835 35 ( ( -LRB- cord-015021-pol2qm74 6835 36 8.7 8.7 CD cord-015021-pol2qm74 6835 37 + + SYM cord-015021-pol2qm74 6835 38 12.5 12.5 CD cord-015021-pol2qm74 6835 39 to to IN cord-015021-pol2qm74 6835 40 17.1 17.1 CD cord-015021-pol2qm74 6835 41 + + CD cord-015021-pol2qm74 6835 42 23.0 23.0 CD cord-015021-pol2qm74 6835 43 ) ) -RRB- cord-015021-pol2qm74 6835 44 . . . cord-015021-pol2qm74 6836 1 In in IN cord-015021-pol2qm74 6836 2 conclusion conclusion NN cord-015021-pol2qm74 6836 3 these these DT cord-015021-pol2qm74 6836 4 data datum NNS cord-015021-pol2qm74 6836 5 indicate indicate VBP cord-015021-pol2qm74 6836 6 that that IN cord-015021-pol2qm74 6836 7 allogeneic allogeneic IN cord-015021-pol2qm74 6836 8 blood blood NN cord-015021-pol2qm74 6836 9 transfusions transfusion NNS cord-015021-pol2qm74 6836 10 lead lead VBP cord-015021-pol2qm74 6836 11 to to IN cord-015021-pol2qm74 6836 12 a a DT cord-015021-pol2qm74 6836 13 remarkable remarkable JJ cord-015021-pol2qm74 6836 14 macrophage macrophage NN cord-015021-pol2qm74 6836 15 / / SYM cord-015021-pol2qm74 6836 16 RHS RHS NNP cord-015021-pol2qm74 6836 17 stimulation stimulation NN cord-015021-pol2qm74 6836 18 . . . cord-015021-pol2qm74 6837 1 This this DT cord-015021-pol2qm74 6837 2 is be VBZ cord-015021-pol2qm74 6837 3 corroborated corroborate VBN cord-015021-pol2qm74 6837 4 by by IN cord-015021-pol2qm74 6837 5 the the DT cord-015021-pol2qm74 6837 6 boostered boostered NNP cord-015021-pol2qm74 6837 7 humoral humoral NNP cord-015021-pol2qm74 6837 8 IgG IgG NNP cord-015021-pol2qm74 6837 9 - - HYPH cord-015021-pol2qm74 6837 10 response response NN cord-015021-pol2qm74 6837 11 which which WDT cord-015021-pol2qm74 6837 12 was be VBD cord-015021-pol2qm74 6837 13 initiated initiate VBN cord-015021-pol2qm74 6837 14 before before IN cord-015021-pol2qm74 6837 15 onset onset NN cord-015021-pol2qm74 6837 16 of of IN cord-015021-pol2qm74 6837 17 surgical surgical JJ cord-015021-pol2qm74 6837 18 trauma trauma NN cord-015021-pol2qm74 6837 19 and and CC cord-015021-pol2qm74 6837 20 blood blood NN cord-015021-pol2qm74 6837 21 transfusion transfusion NN cord-015021-pol2qm74 6837 22 . . . cord-015021-pol2qm74 6838 1 Concerning concern VBG cord-015021-pol2qm74 6838 2 CMI CMI NNP cord-015021-pol2qm74 6839 1 this this DT cord-015021-pol2qm74 6839 2 caused cause VBD cord-015021-pol2qm74 6839 3 a a DT cord-015021-pol2qm74 6839 4 substancial substancial JJ cord-015021-pol2qm74 6839 5 suppression suppression NN cord-015021-pol2qm74 6839 6 probably probably RB cord-015021-pol2qm74 6839 7 due due IN cord-015021-pol2qm74 6839 8 to to IN cord-015021-pol2qm74 6839 9 a a DT cord-015021-pol2qm74 6839 10 stimulated stimulated JJ cord-015021-pol2qm74 6839 11 secretion secretion NN cord-015021-pol2qm74 6839 12 of of IN cord-015021-pol2qm74 6839 13 immunosuppressive immunosuppressive JJ cord-015021-pol2qm74 6839 14 monokines monokine NNS cord-015021-pol2qm74 6839 15 . . . cord-015021-pol2qm74 6840 1 Objective objective NN cord-015021-pol2qm74 6840 2 : : : cord-015021-pol2qm74 6841 1 Firstly firstly RB cord-015021-pol2qm74 6841 2 , , , cord-015021-pol2qm74 6841 3 to to TO cord-015021-pol2qm74 6841 4 analyse analyse VB cord-015021-pol2qm74 6841 5 the the DT cord-015021-pol2qm74 6841 6 concentrations concentration NNS cord-015021-pol2qm74 6841 7 of of IN cord-015021-pol2qm74 6841 8 the the DT cord-015021-pol2qm74 6841 9 cytokines cytokine NNS cord-015021-pol2qm74 6841 10 tumor tumor NN cord-015021-pol2qm74 6841 11 necrosis necrosis NN cord-015021-pol2qm74 6841 12 factor factor NN cord-015021-pol2qm74 6841 13 ( ( -LRB- cord-015021-pol2qm74 6841 14 TNc TNc NNP cord-015021-pol2qm74 6841 15 ) ) -RRB- cord-015021-pol2qm74 6841 16 , , , cord-015021-pol2qm74 6841 17 interleukin-1 interleukin-1 FW cord-015021-pol2qm74 6841 18 ( ( -LRB- cord-015021-pol2qm74 6841 19 IL IL NNP cord-015021-pol2qm74 6841 20 - - HYPH cord-015021-pol2qm74 6841 21 I I NNP cord-015021-pol2qm74 6841 22 ) ) -RRB- cord-015021-pol2qm74 6841 23 , , , cord-015021-pol2qm74 6841 24 interleukin-6 interleukin-6 NNP cord-015021-pol2qm74 6841 25 ( ( -LRB- cord-015021-pol2qm74 6841 26 IL-6 IL-6 NNP cord-015021-pol2qm74 6841 27 ) ) -RRB- cord-015021-pol2qm74 6841 28 and and CC cord-015021-pol2qm74 6841 29 coagulatioo coagulatioo NNP cord-015021-pol2qm74 6841 30 / / SYM cord-015021-pol2qm74 6841 31 fibrinolysis fibrinolysis NN cord-015021-pol2qm74 6841 32 parameters parameter NNS cord-015021-pol2qm74 6841 33 in in IN cord-015021-pol2qm74 6841 34 postoperatively postoperatively RB cord-015021-pol2qm74 6841 35 retrieved retrieve VBN cord-015021-pol2qm74 6841 36 blood blood NN cord-015021-pol2qm74 6841 37 from from IN cord-015021-pol2qm74 6841 38 a a DT cord-015021-pol2qm74 6841 39 surgical surgical JJ cord-015021-pol2qm74 6841 40 area area NN cord-015021-pol2qm74 6841 41 , , , cord-015021-pol2qm74 6841 42 secondly secondly RB cord-015021-pol2qm74 6841 43 to to TO cord-015021-pol2qm74 6841 44 characterize characterize VB cord-015021-pol2qm74 6841 45 the the DT cord-015021-pol2qm74 6841 46 correspanding correspande VBG cord-015021-pol2qm74 6841 47 cytokine cytokine NN cord-015021-pol2qm74 6841 48 patters patter NNS cord-015021-pol2qm74 6841 49 in in IN cord-015021-pol2qm74 6841 50 the the DT cord-015021-pol2qm74 6841 51 patients patient NNS cord-015021-pol2qm74 6841 52 and and CC cord-015021-pol2qm74 6841 53 thirdly thirdly RB cord-015021-pol2qm74 6841 54 to to TO cord-015021-pol2qm74 6841 55 study study VB cord-015021-pol2qm74 6841 56 cytokine cytokine JJ cord-015021-pol2qm74 6841 57 concentrations concentration NNS cord-015021-pol2qm74 6841 58 in in IN cord-015021-pol2qm74 6841 59 the the DT cord-015021-pol2qm74 6841 60 initial initial JJ cord-015021-pol2qm74 6841 61 portion portion NN cord-015021-pol2qm74 6841 62 of of IN cord-015021-pol2qm74 6841 63 drainage drainage NN cord-015021-pol2qm74 6841 64 blood blood NN cord-015021-pol2qm74 6841 65 from from IN cord-015021-pol2qm74 6841 66 a a DT cord-015021-pol2qm74 6841 67 surgical surgical JJ cord-015021-pol2qm74 6841 68 area area NN cord-015021-pol2qm74 6841 69 . . . cord-015021-pol2qm74 6842 1 Materials material NNS cord-015021-pol2qm74 6842 2 and and CC cord-015021-pol2qm74 6842 3 Methods method NNS cord-015021-pol2qm74 6842 4 : : : cord-015021-pol2qm74 6842 5 Blood blood NN cord-015021-pol2qm74 6842 6 retrieval retrieval NN cord-015021-pol2qm74 6842 7 was be VBD cord-015021-pol2qm74 6842 8 performed perform VBN cord-015021-pol2qm74 6842 9 in in IN cord-015021-pol2qm74 6842 10 a a DT cord-015021-pol2qm74 6842 11 closed closed JJ cord-015021-pol2qm74 6842 12 - - HYPH cord-015021-pol2qm74 6842 13 loop loop NN cord-015021-pol2qm74 6842 14 system system NN cord-015021-pol2qm74 6842 15 without without IN cord-015021-pol2qm74 6842 16 anticoagulant anticoagulant NN cord-015021-pol2qm74 6842 17 during during IN cord-015021-pol2qm74 6842 18 4 4 CD cord-015021-pol2qm74 6842 19 - - SYM cord-015021-pol2qm74 6842 20 6 6 CD cord-015021-pol2qm74 6842 21 hours hour NNS cord-015021-pol2qm74 6842 22 after after IN cord-015021-pol2qm74 6842 23 surgery surgery NN cord-015021-pol2qm74 6842 24 in in IN cord-015021-pol2qm74 6842 25 10 10 CD cord-015021-pol2qm74 6842 26 patients patient NNS cord-015021-pol2qm74 6842 27 undergoing undergo VBG cord-015021-pol2qm74 6842 28 arthroplasty arthroplasty NNP cord-015021-pol2qm74 6842 29 ( ( -LRB- cord-015021-pol2qm74 6842 30 9 9 CD cord-015021-pol2qm74 6842 31 hips hip NNS cord-015021-pol2qm74 6842 32 and and CC cord-015021-pol2qm74 6842 33 1 1 CD cord-015021-pol2qm74 6842 34 knee knee NN cord-015021-pol2qm74 6842 35 ) ) -RRB- cord-015021-pol2qm74 6842 36 . . . cord-015021-pol2qm74 6843 1 7KF 7kf CD cord-015021-pol2qm74 6843 2 , , , cord-015021-pol2qm74 6843 3 IL-1 IL-1 NNP cord-015021-pol2qm74 6843 4 , , , cord-015021-pol2qm74 6843 5 It-6 It-6 NNP cord-015021-pol2qm74 6843 6 , , , cord-015021-pol2qm74 6843 7 thrembin thrembin NN cord-015021-pol2qm74 6843 8 - - HYPH cord-015021-pol2qm74 6843 9 antithrombin antithrombin NN cord-015021-pol2qm74 6843 10 complexes complex NNS cord-015021-pol2qm74 6843 11 ( ( -LRB- cord-015021-pol2qm74 6843 12 TAC TAC NNP cord-015021-pol2qm74 6843 13 ) ) -RRB- cord-015021-pol2qm74 6843 14 and and CC cord-015021-pol2qm74 6843 15 antithrombin antithrombin NN cord-015021-pol2qm74 6843 16 ( ( -LRB- cord-015021-pol2qm74 6843 17 AT at IN cord-015021-pol2qm74 6843 18 ) ) -RRB- cord-015021-pol2qm74 6844 1 ~ere ~ere NNP cord-015021-pol2qm74 6844 2 determined determine VBN cord-015021-pol2qm74 6844 3 in in IN cord-015021-pol2qm74 6844 4 shed shed JJ cord-015021-pol2qm74 6844 5 blood blood NN cord-015021-pol2qm74 6844 6 . . . cord-015021-pol2qm74 6845 1 Patient Patient NNP cord-015021-pol2qm74 6845 2 plasma plasma NN cord-015021-pol2qm74 6845 3 TN TN NNP cord-015021-pol2qm74 6845 4 v v NN cord-015021-pol2qm74 6845 5 , , , cord-015021-pol2qm74 6845 6 IL IL NNP cord-015021-pol2qm74 6845 7 - - HYPH cord-015021-pol2qm74 6845 8 I I NNP cord-015021-pol2qm74 6845 9 and and CC cord-015021-pol2qm74 6845 10 IL-6 IL-6 NNP cord-015021-pol2qm74 6845 11 concentrations concentration NNS cord-015021-pol2qm74 6846 1 ~ere ~ere NNP cord-015021-pol2qm74 6846 2 analysed analyse VBD cord-015021-pol2qm74 6846 3 at at IN cord-015021-pol2qm74 6846 4 the the DT cord-015021-pol2qm74 6846 5 beginnLqg beginnlqg NN cord-015021-pol2qm74 6846 6 and and CC cord-015021-pol2qm74 6846 7 end end NN cord-015021-pol2qm74 6846 8 of of IN cord-015021-pol2qm74 6846 9 the the DT cord-015021-pol2qm74 6846 10 4 4 CD cord-015021-pol2qm74 6846 11 - - SYM cord-015021-pol2qm74 6846 12 6 6 CD cord-015021-pol2qm74 6846 13 hour hour NN cord-015021-pol2qm74 6846 14 blood blood NN cord-015021-pol2qm74 6846 15 retrieval retrieval NN cord-015021-pol2qm74 6846 16 period period NN cord-015021-pol2qm74 6846 17 . . . cord-015021-pol2qm74 6847 1 In in IN cord-015021-pol2qm74 6847 2 a a DT cord-015021-pol2qm74 6847 3 separate separate JJ cord-015021-pol2qm74 6847 4 study study NN cord-015021-pol2qm74 6847 5 ( ( -LRB- cord-015021-pol2qm74 6847 6 5 5 CD cord-015021-pol2qm74 6847 7 hip hip NN cord-015021-pol2qm74 6847 8 arthroplasties arthroplasty NNS cord-015021-pol2qm74 6847 9 ) ) -RRB- cord-015021-pol2qm74 6848 1 f f LS cord-015021-pol2qm74 6848 2 ~ ~ NFP cord-015021-pol2qm74 6848 3 F F NNP cord-015021-pol2qm74 6848 4 , , , cord-015021-pol2qm74 6848 5 IL IL NNP cord-015021-pol2qm74 6848 6 - - : cord-015021-pol2qm74 6848 7 I I NNP cord-015021-pol2qm74 6848 8 and and CC cord-015021-pol2qm74 6849 1 IL-6 IL-6 NNP cord-015021-pol2qm74 6849 2 ~ere ~ere NNP cord-015021-pol2qm74 6849 3 determined determine VBN cord-015021-pol2qm74 6849 4 in in IN cord-015021-pol2qm74 6849 5 the the DT cord-015021-pol2qm74 6849 6 initial initial JJ cord-015021-pol2qm74 6849 7 portion portion NN cord-015021-pol2qm74 6849 8 of of IN cord-015021-pol2qm74 6849 9 drainage drainage NN cord-015021-pol2qm74 6849 10 blood blood NN cord-015021-pol2qm74 6849 11 . . . cord-015021-pol2qm74 6850 1 Cytekine cytekine NN cord-015021-pol2qm74 6850 2 analyses analysis NNS cord-015021-pol2qm74 6850 3 ~re ~re NNP cord-015021-pol2qm74 6850 4 performed perform VBD cord-015021-pol2qm74 6850 5 usiog usiog NNP cord-015021-pol2qm74 6850 6 ipmuooassays ipmuooassays NNP cord-015021-pol2qm74 6850 7 . . . cord-015021-pol2qm74 6851 1 An an DT cord-015021-pol2qm74 6851 2 omidolytic omidolytic JJ cord-015021-pol2qm74 6851 3 method method NN cord-015021-pol2qm74 6851 4 was be VBD cord-015021-pol2qm74 6851 5 used use VBN cord-015021-pol2qm74 6851 6 for for IN cord-015021-pol2qm74 6851 7 AT AT NNP cord-015021-pol2qm74 6851 8 determinaf.ion determinaf.ion NNP cord-015021-pol2qm74 6851 9 and and CC cord-015021-pol2qm74 6851 10 TAC TAC NNP cord-015021-pol2qm74 6851 11 was be VBD cord-015021-pol2qm74 6851 12 analysed analyse VBN cord-015021-pol2qm74 6851 13 by by IN cord-015021-pol2qm74 6851 14 ELISA ELISA NNP cord-015021-pol2qm74 6851 15 . . . cord-015021-pol2qm74 6852 1 N N NNP cord-015021-pol2qm74 6852 2 ~ ~ CD cord-015021-pol2qm74 6852 3 n n NN cord-015021-pol2qm74 6852 4 - - HYPH cord-015021-pol2qm74 6852 5 poram poram NNP cord-015021-pol2qm74 6852 6 ~ ~ NFP cord-015021-pol2qm74 6852 7 tric tric JJ cord-015021-pol2qm74 6852 8 tests test NNS cord-015021-pol2qm74 6852 9 was be VBD cord-015021-pol2qm74 6852 10 used use VBN cord-015021-pol2qm74 6852 11 for for IN cord-015021-pol2qm74 6852 12 the the DT cord-015021-pol2qm74 6852 13 statistical statistical JJ cord-015021-pol2qm74 6852 14 comparison comparison NN cord-015021-pol2qm74 6852 15 . . . cord-015021-pol2qm74 6853 1 Results result NNS cord-015021-pol2qm74 6853 2 : : : cord-015021-pol2qm74 6854 1 The the DT cord-015021-pol2qm74 6854 2 patient patient NN cord-015021-pol2qm74 6854 3 plasma plasma NN cord-015021-pol2qm74 6854 4 IL-6 IL-6 NNP cord-015021-pol2qm74 6854 5 coocemtratiems coocemtratiem NNS cord-015021-pol2qm74 6854 6 rose rise VBD cord-015021-pol2qm74 6854 7 from from IN cord-015021-pol2qm74 6854 8 a a DT cord-015021-pol2qm74 6854 9 median median JJ cord-015021-pol2qm74 6854 10 value value NN cord-015021-pol2qm74 6854 11 of of IN cord-015021-pol2qm74 6854 12 0 0 CD cord-015021-pol2qm74 6854 13 to to IN cord-015021-pol2qm74 6854 14 116 116 CD cord-015021-pol2qm74 6854 15 pg pg NN cord-015021-pol2qm74 6854 16 / / SYM cord-015021-pol2qm74 6854 17 ml ml NN cord-015021-pol2qm74 6854 18 , , , cord-015021-pol2qm74 6854 19 p p NN cord-015021-pol2qm74 6854 20 < < XX cord-015021-pol2qm74 6855 1 O.01 o.01 CD cord-015021-pol2qm74 6855 2 , , , cord-015021-pol2qm74 6855 3 during during IN cord-015021-pol2qm74 6855 4 the the DT cord-015021-pol2qm74 6855 5 blood blood NN cord-015021-pol2qm74 6855 6 ret.rieval ret.rieval NNP cord-015021-pol2qm74 6855 7 period period NN cord-015021-pol2qm74 6855 8 . . . cord-015021-pol2qm74 6856 1 IN in IN cord-015021-pol2qm74 6856 2 c c NNP cord-015021-pol2qm74 6856 3 was be VBD cord-015021-pol2qm74 6856 4 detectable detectable JJ cord-015021-pol2qm74 6856 5 in in IN cord-015021-pol2qm74 6856 6 4 4 CD cord-015021-pol2qm74 6856 7 patients patient NNS cord-015021-pol2qm74 6856 8 , , , cord-015021-pol2qm74 6856 9 range:15 range:15 NNP cord-015021-pol2qm74 6856 10 - - HYPH cord-015021-pol2qm74 6856 11 50 50 CD cord-015021-pol2qm74 6856 12 pg pg NN cord-015021-pol2qm74 6856 13 / / SYM cord-015021-pol2qm74 6856 14 ml ml NN cord-015021-pol2qm74 6856 15 . . . cord-015021-pol2qm74 6857 1 IL IL NNP cord-015021-pol2qm74 6857 2 - - : cord-015021-pol2qm74 6857 3 I -PRON- PRP cord-015021-pol2qm74 6857 4 was be VBD cord-015021-pol2qm74 6857 5 not not RB cord-015021-pol2qm74 6857 6 detectable detectable JJ cord-015021-pol2qm74 6857 7 in in IN cord-015021-pol2qm74 6857 8 the the DT cord-015021-pol2qm74 6857 9 patients patient NNS cord-015021-pol2qm74 6857 10 . . . cord-015021-pol2qm74 6858 1 In in IN cord-015021-pol2qm74 6858 2 retrieved retrieve VBN cord-015021-pol2qm74 6858 3 blood blood NN cord-015021-pol2qm74 6858 4 TAG tag NN cord-015021-pol2qm74 6858 5 was be VBD cord-015021-pol2qm74 6858 6 > > NFP cord-015021-pol2qm74 6858 7 200 200 CD cord-015021-pol2qm74 6858 8 mg mg NNP cord-015021-pol2qm74 6858 9 / / SYM cord-015021-pol2qm74 6858 10 ml ml XX cord-015021-pol2qm74 6858 11 in in IN cord-015021-pol2qm74 6858 12 all all DT cord-015021-pol2qm74 6858 13 samples sample NNS cord-015021-pol2qm74 6859 1 ( ( -LRB- cord-015021-pol2qm74 6859 2 ref:<4.1 ref:<4.1 NNP cord-015021-pol2qm74 6859 3 mg mg NNP cord-015021-pol2qm74 6859 4 / / SYM cord-015021-pol2qm74 6859 5 ml ml NNP cord-015021-pol2qm74 6859 6 ) ) -RRB- cord-015021-pol2qm74 6859 7 and and CC cord-015021-pol2qm74 6859 8 AT AT NNP cord-015021-pol2qm74 6859 9 was be VBD cord-015021-pol2qm74 6859 10 0 0 CD cord-015021-pol2qm74 6859 11 . . . cord-015021-pol2qm74 6860 1 16 16 CD cord-015021-pol2qm74 6860 2 - - SYM cord-015021-pol2qm74 6860 3 0.51 0.51 CD cord-015021-pol2qm74 6860 4 units unit NNS cord-015021-pol2qm74 6860 5 / / SYM cord-015021-pol2qm74 6860 6 ml ml XX cord-015021-pol2qm74 6861 1 ( ( -LRB- cord-015021-pol2qm74 6861 2 ref ref NN cord-015021-pol2qm74 6861 3 : : : cord-015021-pol2qm74 6862 1 O.80 o.80 LS cord-015021-pol2qm74 6862 2 - - HYPH cord-015021-pol2qm74 6862 3 1.20 1.20 CD cord-015021-pol2qm74 6862 4 ) ) -RRB- cord-015021-pol2qm74 6862 5 . . . cord-015021-pol2qm74 6863 1 The the DT cord-015021-pol2qm74 6863 2 IL-6 IL-6 NNP cord-015021-pol2qm74 6863 3 concentrations concentration NNS cord-015021-pol2qm74 6863 4 in in IN cord-015021-pol2qm74 6863 5 retrieved retrieve VBN cord-015021-pol2qm74 6863 6 blood blood NN cord-015021-pol2qm74 6863 7 was be VBD cord-015021-pol2qm74 6863 8 > > NFP cord-015021-pol2qm74 6863 9 1000 1000 CD cord-015021-pol2qm74 6863 10 pg pg NN cord-015021-pol2qm74 6863 11 / / SYM cord-015021-pol2qm74 6863 12 ml ml XX cord-015021-pol2qm74 6863 13 in in IN cord-015021-pol2qm74 6863 14 all all DT cord-015021-pol2qm74 6863 15 samples sample NNS cord-015021-pol2qm74 6863 16 . . . cord-015021-pol2qm74 6864 1 TN TN NNP cord-015021-pol2qm74 6864 2 v v NN cord-015021-pol2qm74 6864 3 or or CC cord-015021-pol2qm74 6864 4 IL IL NNP cord-015021-pol2qm74 6864 5 - - : cord-015021-pol2qm74 6864 6 I -PRON- PRP cord-015021-pol2qm74 6864 7 was be VBD cord-015021-pol2qm74 6864 8 not not RB cord-015021-pol2qm74 6864 9 detectable detectable JJ cord-015021-pol2qm74 6864 10 . . . cord-015021-pol2qm74 6865 1 In in IN cord-015021-pol2qm74 6865 2 the the DT cord-015021-pol2qm74 6865 3 separate separate JJ cord-015021-pol2qm74 6865 4 study study NN cord-015021-pol2qm74 6865 5 , , , cord-015021-pol2qm74 6865 6 ( ( -LRB- cord-015021-pol2qm74 6865 7 n=5 n=5 NNP cord-015021-pol2qm74 6865 8 ) ) -RRB- cord-015021-pol2qm74 6865 9 , , , cord-015021-pol2qm74 6865 10 characterlzing characterlze VBG cord-015021-pol2qm74 6865 11 eytokine eytokine JJ cord-015021-pol2qm74 6865 12 content content NN cord-015021-pol2qm74 6865 13 in in IN cord-015021-pol2qm74 6865 14 the the DT cord-015021-pol2qm74 6865 15 initial initial JJ cord-015021-pol2qm74 6865 16 portiere portiere NN cord-015021-pol2qm74 6865 17 of of IN cord-015021-pol2qm74 6865 18 drainage drainage NN cord-015021-pol2qm74 6865 19 blood blood NN cord-015021-pol2qm74 6865 20 , , , cord-015021-pol2qm74 6865 21 IN= IN= '' cord-015021-pol2qm74 6866 1 ( ( -LRB- cord-015021-pol2qm74 6866 2 range range NN cord-015021-pol2qm74 6866 3 : : : cord-015021-pol2qm74 6866 4 11 11 CD cord-015021-pol2qm74 6866 5 - - SYM cord-015021-pol2qm74 6866 6 277 277 CD cord-015021-pol2qm74 6866 7 pg pg NN cord-015021-pol2qm74 6866 8 / / SYM cord-015021-pol2qm74 6866 9 ml ml NN cord-015021-pol2qm74 6866 10 ) ) -RRB- cord-015021-pol2qm74 6866 11 and and CC cord-015021-pol2qm74 6866 12 IL IL NNP cord-015021-pol2qm74 6866 13 - - : cord-015021-pol2qm74 6866 14 I I NNP cord-015021-pol2qm74 6867 1 ( ( -LRB- cord-015021-pol2qm74 6867 2 range:5 range:5 NN cord-015021-pol2qm74 6867 3 - - HYPH cord-015021-pol2qm74 6867 4 125 125 CD cord-015021-pol2qm74 6867 5 pg pg NN cord-015021-pol2qm74 6867 6 / / SYM cord-015021-pol2qm74 6867 7 ml ml NN cord-015021-pol2qm74 6867 8 ) ) -RRB- cord-015021-pol2qm74 6868 1 ~re ~re NN cord-015021-pol2qm74 6868 2 present present JJ cord-015021-pol2qm74 6868 3 in in IN cord-015021-pol2qm74 6868 4 all all DT cord-015021-pol2qm74 6868 5 samples sample NNS cord-015021-pol2qm74 6869 1 but but CC cord-015021-pol2qm74 6869 2 II-6 II-6 NNP cord-015021-pol2qm74 6869 3 ( ( -LRB- cord-015021-pol2qm74 6869 4 range range NN cord-015021-pol2qm74 6869 5 : : : cord-015021-pol2qm74 6869 6 O-25 O-25 NNP cord-015021-pol2qm74 6869 7 pg pg NNP cord-015021-pol2qm74 6869 8 / / SYM cord-015021-pol2qm74 6869 9 ml ml NN cord-015021-pol2qm74 6869 10 ) ) -RRB- cord-015021-pol2qm74 6869 11 was be VBD cord-015021-pol2qm74 6869 12 detectable detectable JJ cord-015021-pol2qm74 6869 13 in in IN cord-015021-pol2qm74 6869 14 o.qly o.qly VBG cord-015021-pol2qm74 6869 15 one one CD cord-015021-pol2qm74 6869 16 semple semple NNP cord-015021-pol2qm74 6869 17 . . . cord-015021-pol2qm74 6870 1 Conclusion conclusion NN cord-015021-pol2qm74 6870 2 : : : cord-015021-pol2qm74 6871 1 These these DT cord-015021-pol2qm74 6871 2 s s POS cord-015021-pol2qm74 6871 3 findings finding NNS cord-015021-pol2qm74 6871 4 indicate indicate VBP cord-015021-pol2qm74 6871 5 that that IN cord-015021-pol2qm74 6871 6 hypereoagulability hypereoagulability NN cord-015021-pol2qm74 6871 7 and and CC cord-015021-pol2qm74 6871 8 hic~ hic~ NNP cord-015021-pol2qm74 6871 9 ccrcentratioos ccrcentratioo NNS cord-015021-pol2qm74 6871 10 are be VBP cord-015021-pol2qm74 6871 11 present present JJ cord-015021-pol2qm74 6871 12 in in IN cord-015021-pol2qm74 6871 13 retrieved retrieve VBN cord-015021-pol2qm74 6871 14 blood blood NN cord-015021-pol2qm74 6871 15 . . . cord-015021-pol2qm74 6872 1 The the DT cord-015021-pol2qm74 6872 2 cytokine cytokine NN cord-015021-pol2qm74 6872 3 pattern pattern NN cord-015021-pol2qm74 6872 4 in in IN cord-015021-pol2qm74 6872 5 the the DT cord-015021-pol2qm74 6872 6 initial initial JJ cord-015021-pol2qm74 6872 7 portion portion NN cord-015021-pol2qm74 6872 8 of of IN cord-015021-pol2qm74 6872 9 blood blood NN cord-015021-pol2qm74 6872 10 from from IN cord-015021-pol2qm74 6872 11 a a DT cord-015021-pol2qm74 6872 12 surgical surgical JJ cord-015021-pol2qm74 6872 13 area area NN cord-015021-pol2qm74 6872 14 differed differ VBD cord-015021-pol2qm74 6872 15 from from IN cord-015021-pol2qm74 6872 16 these these DT cord-015021-pol2qm74 6872 17 observed observe VBN cord-015021-pol2qm74 6872 18 in in IN cord-015021-pol2qm74 6872 19 retrieved retrieve VBN cord-015021-pol2qm74 6872 20 blood blood NN cord-015021-pol2qm74 6872 21 and and CC cord-015021-pol2qm74 6872 22 in in IN cord-015021-pol2qm74 6872 23 the the DT cord-015021-pol2qm74 6872 24 systemic systemic JJ cord-015021-pol2qm74 6872 25 circulation circulation NN cord-015021-pol2qm74 6872 26 . . . cord-015021-pol2qm74 6873 1 To to TO cord-015021-pol2qm74 6873 2 identify identify VB cord-015021-pol2qm74 6873 3 the the DT cord-015021-pol2qm74 6873 4 role role NN cord-015021-pol2qm74 6873 5 of of IN cord-015021-pol2qm74 6873 6 both both DT cord-015021-pol2qm74 6873 7 autOlogous autologous JJ cord-015021-pol2qm74 6873 8 and and CC cord-015021-pol2qm74 6873 9 homologous homologous JJ cord-015021-pol2qm74 6873 10 blood blood NN cord-015021-pol2qm74 6873 11 on on IN cord-015021-pol2qm74 6873 12 postoperative postoperative JJ cord-015021-pol2qm74 6873 13 infections infection NNS cord-015021-pol2qm74 6873 14 in in IN cord-015021-pol2qm74 6873 15 elective elective JJ cord-015021-pol2qm74 6873 16 cancer cancer NN cord-015021-pol2qm74 6873 17 surgery surgery NN cord-015021-pol2qm74 6873 18 . . . cord-015021-pol2qm74 6874 1 Materials material NNS cord-015021-pol2qm74 6874 2 and and CC cord-015021-pol2qm74 6874 3 methods method NNS cord-015021-pol2qm74 6874 4 : : : cord-015021-pol2qm74 6874 5 159 159 CD cord-015021-pol2qm74 6874 6 patients patient NNS cord-015021-pol2qm74 6874 7 with with IN cord-015021-pol2qm74 6874 8 colo colo JJ cord-015021-pol2qm74 6874 9 - - HYPH cord-015021-pol2qm74 6874 10 rectal rectal JJ cord-015021-pol2qm74 6874 11 cancer cancer NN cord-015021-pol2qm74 6874 12 submitted submit VBN cord-015021-pol2qm74 6874 13 to to IN cord-015021-pol2qm74 6874 14 curative curative JJ cord-015021-pol2qm74 6874 15 elective elective JJ cord-015021-pol2qm74 6874 16 surgery surgery NN cord-015021-pol2qm74 6874 17 were be VBD cord-015021-pol2qm74 6874 18 prospectively prospectively RB cord-015021-pol2qm74 6874 19 studied study VBN cord-015021-pol2qm74 6874 20 . . . cord-015021-pol2qm74 6875 1 On on IN cord-015021-pol2qm74 6875 2 hospital hospital NN cord-015021-pol2qm74 6875 3 admission admission NN cord-015021-pol2qm74 6875 4 the the DT cord-015021-pol2qm74 6875 5 following follow VBG cord-015021-pol2qm74 6875 6 nutritional nutritional JJ cord-015021-pol2qm74 6875 7 measurements measurement NNS cord-015021-pol2qm74 6875 8 were be VBD cord-015021-pol2qm74 6875 9 assessed assess VBN cord-015021-pol2qm74 6875 10 : : : cord-015021-pol2qm74 6875 11 serum serum NN cord-015021-pol2qm74 6875 12 level level NN cord-015021-pol2qm74 6875 13 of of IN cord-015021-pol2qm74 6875 14 albumin albumin NN cord-015021-pol2qm74 6875 15 , , , cord-015021-pol2qm74 6875 16 cholinesterase cholinesterase NN cord-015021-pol2qm74 6875 17 , , , cord-015021-pol2qm74 6875 18 delayed delay VBN cord-015021-pol2qm74 6875 19 hypersensivity hypersensivity NN cord-015021-pol2qm74 6875 20 response response NN cord-015021-pol2qm74 6875 21 , , , cord-015021-pol2qm74 6875 22 total total JJ cord-015021-pol2qm74 6875 23 lymphocyte lymphocyte NN cord-015021-pol2qm74 6875 24 count count NN cord-015021-pol2qm74 6875 25 and and CC cord-015021-pol2qm74 6875 26 weight weight NN cord-015021-pol2qm74 6875 27 loss loss NN cord-015021-pol2qm74 6875 28 , , , cord-015021-pol2qm74 6875 29 as as IN cord-015021-pol2qm74 6875 30 were be VBD cord-015021-pol2qm74 6875 31 age age NN cord-015021-pol2qm74 6875 32 and and CC cord-015021-pol2qm74 6875 33 sex sex NN cord-015021-pol2qm74 6875 34 , , , cord-015021-pol2qm74 6875 35 Duration duration NN cord-015021-pol2qm74 6875 36 of of IN cord-015021-pol2qm74 6875 37 operation operation NN cord-015021-pol2qm74 6875 38 , , , cord-015021-pol2qm74 6875 39 operative operative JJ cord-015021-pol2qm74 6875 40 blood blood NN cord-015021-pol2qm74 6875 41 loss loss NN cord-015021-pol2qm74 6875 42 , , , cord-015021-pol2qm74 6875 43 amount amount NN cord-015021-pol2qm74 6875 44 and and CC cord-015021-pol2qm74 6875 45 type type NN cord-015021-pol2qm74 6875 46 of of IN cord-015021-pol2qm74 6875 47 blood blood NN cord-015021-pol2qm74 6875 48 given give VBN cord-015021-pol2qm74 6875 49 , , , cord-015021-pol2qm74 6875 50 pathological pathological JJ cord-015021-pol2qm74 6875 51 Dukes duke NNS cord-015021-pol2qm74 6875 52 ' ' POS cord-015021-pol2qm74 6875 53 stage stage NN cord-015021-pol2qm74 6875 54 of of IN cord-015021-pol2qm74 6875 55 the the DT cord-015021-pol2qm74 6875 56 disease disease NN cord-015021-pol2qm74 6875 57 and and CC cord-015021-pol2qm74 6875 58 the the DT cord-015021-pol2qm74 6875 59 attending attend VBG cord-015021-pol2qm74 6875 60 surgeon surgeon NN cord-015021-pol2qm74 6875 61 were be VBD cord-015021-pol2qm74 6875 62 also also RB cord-015021-pol2qm74 6875 63 recorded record VBN cord-015021-pol2qm74 6875 64 . . . cord-015021-pol2qm74 6876 1 Results result NNS cord-015021-pol2qm74 6876 2 : : : cord-015021-pol2qm74 6877 1 Eighty eighty CD cord-015021-pol2qm74 6877 2 - - HYPH cord-015021-pol2qm74 6877 3 four four CD cord-015021-pol2qm74 6877 4 patients patient NNS cord-015021-pol2qm74 6877 5 ( ( -LRB- cord-015021-pol2qm74 6877 6 52.8 52.8 CD cord-015021-pol2qm74 6877 7 % % NN cord-015021-pol2qm74 6877 8 ) ) -RRB- cord-015021-pol2qm74 6877 9 were be VBD cord-015021-pol2qm74 6877 10 perioperatively perioperatively RB cord-015021-pol2qm74 6877 11 transfused transfuse VBN cord-015021-pol2qm74 6877 12 . . . cord-015021-pol2qm74 6878 1 Thirty thirty CD cord-015021-pol2qm74 6878 2 - - HYPH cord-015021-pol2qm74 6878 3 six six CD cord-015021-pol2qm74 6878 4 ( ( -LRB- cord-015021-pol2qm74 6878 5 42.8 42.8 CD cord-015021-pol2qm74 6878 6 % % NN cord-015021-pol2qm74 6878 7 ) ) -RRB- cord-015021-pol2qm74 6878 8 patients patient NNS cord-015021-pol2qm74 6878 9 were be VBD cord-015021-pol2qm74 6878 10 given give VBN cord-015021-pol2qm74 6878 11 autologous autologous JJ cord-015021-pol2qm74 6878 12 blood blood NN cord-015021-pol2qm74 6878 13 , , , cord-015021-pol2qm74 6878 14 while while IN cord-015021-pol2qm74 6878 15 48 48 CD cord-015021-pol2qm74 6878 16 ( ( -LRB- cord-015021-pol2qm74 6878 17 57.2 57.2 CD cord-015021-pol2qm74 6878 18 % % NN cord-015021-pol2qm74 6878 19 ) ) -RRB- cord-015021-pol2qm74 6878 20 received receive VBD cord-015021-pol2qm74 6878 21 homologous homologous JJ cord-015021-pol2qm74 6878 22 blood blood NN cord-015021-pol2qm74 6878 23 . . . cord-015021-pol2qm74 6879 1 No no DT cord-015021-pol2qm74 6879 2 patients patient NNS cord-015021-pol2qm74 6879 3 received receive VBD cord-015021-pol2qm74 6879 4 both both CC cord-015021-pol2qm74 6879 5 autologous autologous JJ cord-015021-pol2qm74 6879 6 and and CC cord-015021-pol2qm74 6879 7 homologous homologous JJ cord-015021-pol2qm74 6879 8 blood blood NN cord-015021-pol2qm74 6879 9 . . . cord-015021-pol2qm74 6880 1 Twenty twenty CD cord-015021-pol2qm74 6880 2 eight eight CD cord-015021-pol2qm74 6880 3 ( ( -LRB- cord-015021-pol2qm74 6880 4 17.9 17.9 CD cord-015021-pol2qm74 6880 5 % % NN cord-015021-pol2qm74 6880 6 ) ) -RRB- cord-015021-pol2qm74 6880 7 patients patient NNS cord-015021-pol2qm74 6880 8 developed develop VBD cord-015021-pol2qm74 6880 9 postoperative postoperative JJ cord-015021-pol2qm74 6880 10 infections infection NNS cord-015021-pol2qm74 6880 11 . . . cord-015021-pol2qm74 6881 1 Non non JJ cord-015021-pol2qm74 6881 2 transfused transfuse VBN cord-015021-pol2qm74 6881 3 patients patient NNS cord-015021-pol2qm74 6881 4 had have VBD cord-015021-pol2qm74 6881 5 a a DT cord-015021-pol2qm74 6881 6 9.3 9.3 CD cord-015021-pol2qm74 6881 7 % % NN cord-015021-pol2qm74 6881 8 infection infection NN cord-015021-pol2qm74 6881 9 rate rate NN cord-015021-pol2qm74 6881 10 , , , cord-015021-pol2qm74 6881 11 those those DT cord-015021-pol2qm74 6881 12 receiving receive VBG cord-015021-pol2qm74 6881 13 autologous autologous JJ cord-015021-pol2qm74 6881 14 blood blood NN cord-015021-pol2qm74 6881 15 had have VBD cord-015021-pol2qm74 6881 16 a a DT cord-015021-pol2qm74 6881 17 13.9 13.9 CD cord-015021-pol2qm74 6881 18 % % NN cord-015021-pol2qm74 6881 19 infection infection NN cord-015021-pol2qm74 6881 20 rate rate NN cord-015021-pol2qm74 6881 21 , , , cord-015021-pol2qm74 6881 22 whi]e whi]e NNP cord-015021-pol2qm74 6881 23 in in IN cord-015021-pol2qm74 6881 24 the the DT cord-015021-pol2qm74 6881 25 homologous homologous JJ cord-015021-pol2qm74 6881 26 blood blood NN cord-015021-pol2qm74 6881 27 group group NN cord-015021-pol2qm74 6881 28 the the DT cord-015021-pol2qm74 6881 29 infection infection NN cord-015021-pol2qm74 6881 30 rate rate NN cord-015021-pol2qm74 6881 31 was be VBD cord-015021-pol2qm74 6881 32 33.3 33.3 CD cord-015021-pol2qm74 6881 33 % % NN cord-015021-pol2qm74 6881 34 ( ( -LRB- cord-015021-pol2qm74 6881 35 p p NN cord-015021-pol2qm74 6881 36 < < XX cord-015021-pol2qm74 6881 37 0.001 0.001 CD cord-015021-pol2qm74 6881 38 ) ) -RRB- cord-015021-pol2qm74 6881 39 . . . cord-015021-pol2qm74 6882 1 Univariate Univariate NNP cord-015021-pol2qm74 6882 2 analysis analysis NN cord-015021-pol2qm74 6882 3 showed show VBD cord-015021-pol2qm74 6882 4 that that IN cord-015021-pol2qm74 6882 5 infections infection NNS cord-015021-pol2qm74 6882 6 were be VBD cord-015021-pol2qm74 6882 7 significantly significantly RB cord-015021-pol2qm74 6882 8 related relate VBN cord-015021-pol2qm74 6882 9 to to IN cord-015021-pol2qm74 6882 10 operative operative JJ cord-015021-pol2qm74 6882 11 blood blood NN cord-015021-pol2qm74 6882 12 loss loss NN cord-015021-pol2qm74 6882 13 ( ( -LRB- cord-015021-pol2qm74 6882 14 p<0.01 p<0.01 NNP cord-015021-pol2qm74 6882 15 ) ) -RRB- cord-015021-pol2qm74 6882 16 , , , cord-015021-pol2qm74 6882 17 length length NN cord-015021-pol2qm74 6882 18 of of IN cord-015021-pol2qm74 6882 19 operation operation NN cord-015021-pol2qm74 6882 20 ( ( -LRB- cord-015021-pol2qm74 6882 21 p<0.05 p<0.05 CD cord-015021-pol2qm74 6882 22 ) ) -RRB- cord-015021-pol2qm74 6883 1 blood blood NN cord-015021-pol2qm74 6883 2 transfusion transfusion NN cord-015021-pol2qm74 6883 3 ( ( -LRB- cord-015021-pol2qm74 6883 4 p<0.05 p<0.05 CD cord-015021-pol2qm74 6883 5 ) ) -RRB- cord-015021-pol2qm74 6883 6 and and CC cord-015021-pol2qm74 6883 7 attending attend VBG cord-015021-pol2qm74 6883 8 surgeon surgeon NN cord-015021-pol2qm74 6883 9 ( ( -LRB- cord-015021-pol2qm74 6883 10 p<0.05 p<0.05 NNP cord-015021-pol2qm74 6883 11 ) ) -RRB- cord-015021-pol2qm74 6883 12 . . . cord-015021-pol2qm74 6884 1 Multivariate multivariate JJ cord-015021-pol2qm74 6884 2 analysis analysis NN cord-015021-pol2qm74 6884 3 identified identify VBD cord-015021-pol2qm74 6884 4 homologous homologous JJ cord-015021-pol2qm74 6884 5 blood blood NN cord-015021-pol2qm74 6884 6 transfusion transfusion NN cord-015021-pol2qm74 6884 7 as as IN cord-015021-pol2qm74 6884 8 the the DT cord-015021-pol2qm74 6884 9 only only JJ cord-015021-pol2qm74 6884 10 variable variable NN cord-015021-pol2qm74 6884 11 related relate VBN cord-015021-pol2qm74 6884 12 to to IN cord-015021-pol2qm74 6884 13 the the DT cord-015021-pol2qm74 6884 14 occurrence occurrence NN cord-015021-pol2qm74 6884 15 of of IN cord-015021-pol2qm74 6884 16 postoperative postoperative JJ cord-015021-pol2qm74 6884 17 infections infection NNS cord-015021-pol2qm74 6884 18 , , , cord-015021-pol2qm74 6884 19 while while IN cord-015021-pol2qm74 6884 20 the the DT cord-015021-pol2qm74 6884 21 other other JJ cord-015021-pol2qm74 6884 22 variables variable NNS cord-015021-pol2qm74 6884 23 failed fail VBD cord-015021-pol2qm74 6884 24 to to TO cord-015021-pol2qm74 6884 25 reach reach VB cord-015021-pol2qm74 6884 26 statistical statistical JJ cord-015021-pol2qm74 6884 27 significance significance NN cord-015021-pol2qm74 6884 28 . . . cord-015021-pol2qm74 6885 1 Blood blood NN cord-015021-pol2qm74 6885 2 transfusion transfusion NN cord-015021-pol2qm74 6885 3 ( ( -LRB- cord-015021-pol2qm74 6885 4 BT BT NNP cord-015021-pol2qm74 6885 5 ) ) -RRB- cord-015021-pol2qm74 6885 6 remains remain VBZ cord-015021-pol2qm74 6885 7 an an DT cord-015021-pol2qm74 6885 8 essential essential JJ cord-015021-pol2qm74 6885 9 life life NN cord-015021-pol2qm74 6885 10 - - HYPH cord-015021-pol2qm74 6885 11 saving save VBG cord-015021-pol2qm74 6885 12 treatment treatment NN cord-015021-pol2qm74 6885 13 for for IN cord-015021-pol2qm74 6885 14 surgical surgical JJ cord-015021-pol2qm74 6885 15 patients patient NNS cord-015021-pol2qm74 6885 16 . . . cord-015021-pol2qm74 6886 1 However however RB cord-015021-pol2qm74 6886 2 , , , cord-015021-pol2qm74 6886 3 besides besides IN cord-015021-pol2qm74 6886 4 the the DT cord-015021-pol2qm74 6886 5 beneficial beneficial JJ cord-015021-pol2qm74 6886 6 short short JJ cord-015021-pol2qm74 6886 7 - - HYPH cord-015021-pol2qm74 6886 8 term term NN cord-015021-pol2qm74 6886 9 impacts impact NNS cord-015021-pol2qm74 6886 10 , , , cord-015021-pol2qm74 6886 11 negative negative JJ cord-015021-pol2qm74 6886 12 longer long JJR cord-015021-pol2qm74 6886 13 - - HYPH cord-015021-pol2qm74 6886 14 term term NN cord-015021-pol2qm74 6886 15 effects effect NNS cord-015021-pol2qm74 6886 16 are be VBP cord-015021-pol2qm74 6886 17 observed observe VBN cord-015021-pol2qm74 6886 18 , , , cord-015021-pol2qm74 6886 19 which which WDT cord-015021-pol2qm74 6886 20 include include VBP cord-015021-pol2qm74 6886 21 various various JJ cord-015021-pol2qm74 6886 22 alterations alteration NNS cord-015021-pol2qm74 6886 23 in in IN cord-015021-pol2qm74 6886 24 the the DT cord-015021-pol2qm74 6886 25 immune immune JJ cord-015021-pol2qm74 6886 26 responsiveness responsiveness NN cord-015021-pol2qm74 6886 27 . . . cord-015021-pol2qm74 6887 1 In in IN cord-015021-pol2qm74 6887 2 surgical surgical JJ cord-015021-pol2qm74 6887 3 patients patient NNS cord-015021-pol2qm74 6887 4 these these DT cord-015021-pol2qm74 6887 5 alterations alteration NNS cord-015021-pol2qm74 6887 6 may may MD cord-015021-pol2qm74 6887 7 contribute contribute VB cord-015021-pol2qm74 6887 8 to to IN cord-015021-pol2qm74 6887 9 the the DT cord-015021-pol2qm74 6887 10 increased increase VBN cord-015021-pol2qm74 6887 11 risk risk NN cord-015021-pol2qm74 6887 12 for for IN cord-015021-pol2qm74 6887 13 infections infection NNS cord-015021-pol2qm74 6887 14 and and CC cord-015021-pol2qm74 6887 15 cancer cancer NN cord-015021-pol2qm74 6887 16 recurrence recurrence NN cord-015021-pol2qm74 6887 17 . . . cord-015021-pol2qm74 6888 1 Since since IN cord-015021-pol2qm74 6888 2 relatively relatively RB cord-015021-pol2qm74 6888 3 few few JJ cord-015021-pol2qm74 6888 4 data datum NNS cord-015021-pol2qm74 6888 5 demonstrate demonstrate VBP cord-015021-pol2qm74 6888 6 immunologic immunologic JJ cord-015021-pol2qm74 6888 7 changes change NNS cord-015021-pol2qm74 6888 8 occurring occur VBG cord-015021-pol2qm74 6888 9 in in IN cord-015021-pol2qm74 6888 10 other other JJ cord-015021-pol2qm74 6888 11 lymphoid lymphoid JJ cord-015021-pol2qm74 6888 12 compartments compartment NNS cord-015021-pol2qm74 6888 13 than than IN cord-015021-pol2qm74 6888 14 blood blood NN cord-015021-pol2qm74 6888 15 after after IN cord-015021-pol2qm74 6888 16 BT BT NNP cord-015021-pol2qm74 6888 17 , , , cord-015021-pol2qm74 6888 18 we -PRON- PRP cord-015021-pol2qm74 6888 19 studied study VBD cord-015021-pol2qm74 6888 20 the the DT cord-015021-pol2qm74 6888 21 effect effect NN cord-015021-pol2qm74 6888 22 of of IN cord-015021-pol2qm74 6888 23 ET ET NNP cord-015021-pol2qm74 6888 24 on on IN cord-015021-pol2qm74 6888 25 the the DT cord-015021-pol2qm74 6888 26 frequency frequency NN cord-015021-pol2qm74 6888 27 and and CC cord-015021-pol2qm74 6888 28 responsiveness responsiveness NN cord-015021-pol2qm74 6888 29 of of IN cord-015021-pol2qm74 6888 30 immune immune JJ cord-015021-pol2qm74 6888 31 cells cell NNS cord-015021-pol2qm74 6888 32 in in IN cord-015021-pol2qm74 6888 33 bone bone NN cord-015021-pol2qm74 6888 34 marrow marrow NN cord-015021-pol2qm74 6888 35 ( ( -LRB- cord-015021-pol2qm74 6888 36 BM BM NNP cord-015021-pol2qm74 6888 37 ) ) -RRB- cord-015021-pol2qm74 6888 38 , , , cord-015021-pol2qm74 6888 39 spleen spleen NNS cord-015021-pol2qm74 6888 40 ( ( -LRB- cord-015021-pol2qm74 6888 41 SPL SPL NNP cord-015021-pol2qm74 6888 42 ) ) -RRB- cord-015021-pol2qm74 6888 43 and and CC cord-015021-pol2qm74 6888 44 blood blood NN cord-015021-pol2qm74 6888 45 ( ( -LRB- cord-015021-pol2qm74 6888 46 B b NN cord-015021-pol2qm74 6888 47 ) ) -RRB- cord-015021-pol2qm74 6888 48 in in IN cord-015021-pol2qm74 6888 49 a a DT cord-015021-pol2qm74 6888 50 rat rat NN cord-015021-pol2qm74 6888 51 model model NN cord-015021-pol2qm74 6888 52 . . . cord-015021-pol2qm74 6889 1 Normovalemic Normovalemic NNP cord-015021-pol2qm74 6889 2 , , , cord-015021-pol2qm74 6889 3 2 2 CD cord-015021-pol2qm74 6889 4 month month NN cord-015021-pol2qm74 6889 5 old old JJ cord-015021-pol2qm74 6889 6 rats rat NNS cord-015021-pol2qm74 6889 7 were be VBD cord-015021-pol2qm74 6889 8 transfused transfuse VBN cord-015021-pol2qm74 6889 9 intravenously intravenously RB cord-015021-pol2qm74 6889 10 with with IN cord-015021-pol2qm74 6889 11 syngeneic syngeneic NNS cord-015021-pol2qm74 6889 12 heparinized heparinized NNP cord-015021-pol2qm74 6889 13 venous venous JJ cord-015021-pol2qm74 6889 14 blood blood NN cord-015021-pol2qm74 6889 15 ( ( -LRB- cord-015021-pol2qm74 6889 16 3x2ml 3x2ml CD cord-015021-pol2qm74 6889 17 , , , cord-015021-pol2qm74 6889 18 every every DT cord-015021-pol2qm74 6889 19 other other JJ cord-015021-pol2qm74 6889 20 day day NN cord-015021-pol2qm74 6889 21 ) ) -RRB- cord-015021-pol2qm74 6889 22 , , , cord-015021-pol2qm74 6889 23 and and CC cord-015021-pol2qm74 6889 24 3 3 CD cord-015021-pol2qm74 6889 25 , , , cord-015021-pol2qm74 6889 26 7 7 CD cord-015021-pol2qm74 6889 27 and and CC cord-015021-pol2qm74 6889 28 14 14 CD cord-015021-pol2qm74 6889 29 days day NNS cord-015021-pol2qm74 6889 30 after after IN cord-015021-pol2qm74 6889 31 the the DT cord-015021-pol2qm74 6889 32 last last JJ cord-015021-pol2qm74 6889 33 transfusion transfusion NN cord-015021-pol2qm74 6889 34 BM bm NN cord-015021-pol2qm74 6889 35 cells cell NNS cord-015021-pol2qm74 6889 36 ( ( -LRB- cord-015021-pol2qm74 6889 37 LEH LEH NNP cord-015021-pol2qm74 6889 38 is be VBZ cord-015021-pol2qm74 6889 39 an an DT cord-015021-pol2qm74 6889 40 experimental experimental JJ cord-015021-pol2qm74 6889 41 oxygen oxygen NN cord-015021-pol2qm74 6889 42 - - HYPH cord-015021-pol2qm74 6889 43 carrying carry VBG cord-015021-pol2qm74 6889 44 resuscitation resuscitation NN cord-015021-pol2qm74 6889 45 fluid fluid NN cord-015021-pol2qm74 6889 46 . . . cord-015021-pol2qm74 6890 1 Since since IN cord-015021-pol2qm74 6890 2 LEH LEH NNP cord-015021-pol2qm74 6890 3 is be VBZ cord-015021-pol2qm74 6890 4 cleared clear VBN cord-015021-pol2qm74 6890 5 from from IN cord-015021-pol2qm74 6890 6 the the DT cord-015021-pol2qm74 6890 7 circulation circulation NN cord-015021-pol2qm74 6890 8 primarily primarily RB cord-015021-pol2qm74 6890 9 by by IN cord-015021-pol2qm74 6890 10 the the DT cord-015021-pol2qm74 6890 11 MPS MPS NNP cord-015021-pol2qm74 6890 12 , , , cord-015021-pol2qm74 6890 13 its -PRON- PRP$ cord-015021-pol2qm74 6890 14 effect effect NN cord-015021-pol2qm74 6890 15 on on IN cord-015021-pol2qm74 6890 16 the the DT cord-015021-pol2qm74 6890 17 development development NN cord-015021-pol2qm74 6890 18 of of IN cord-015021-pol2qm74 6890 19 sepsis sepsis NN cord-015021-pol2qm74 6890 20 and and CC cord-015021-pol2qm74 6890 21 the the DT cord-015021-pol2qm74 6890 22 nature nature NN cord-015021-pol2qm74 6890 23 of of IN cord-015021-pol2qm74 6890 24 its -PRON- PRP$ cord-015021-pol2qm74 6890 25 relationship relationship NN cord-015021-pol2qm74 6890 26 with with IN cord-015021-pol2qm74 6890 27 the the DT cord-015021-pol2qm74 6890 28 MPS MPS NNP cord-015021-pol2qm74 6890 29 remain remain VBP cord-015021-pol2qm74 6890 30 a a DT cord-015021-pol2qm74 6890 31 major major JJ cord-015021-pol2qm74 6890 32 concern concern NN cord-015021-pol2qm74 6890 33 . . . cord-015021-pol2qm74 6891 1 Preliminary preliminary JJ cord-015021-pol2qm74 6891 2 in in IN cord-015021-pol2qm74 6891 3 vivo vivo NNP cord-015021-pol2qm74 6891 4 data datum NNS cord-015021-pol2qm74 6891 5 from from IN cord-015021-pol2qm74 6891 6 our -PRON- PRP$ cord-015021-pol2qm74 6891 7 laboratory laboratory NN cord-015021-pol2qm74 6891 8 failed fail VBD cord-015021-pol2qm74 6891 9 to to TO cord-015021-pol2qm74 6891 10 show show VB cord-015021-pol2qm74 6891 11 any any DT cord-015021-pol2qm74 6891 12 LEH LEH NNP cord-015021-pol2qm74 6891 13 effect effect NN cord-015021-pol2qm74 6891 14 on on IN cord-015021-pol2qm74 6891 15 the the DT cord-015021-pol2qm74 6891 16 hemodynamic hemodynamic JJ cord-015021-pol2qm74 6891 17 and and CC cord-015021-pol2qm74 6891 18 hematologic hematologic JJ cord-015021-pol2qm74 6891 19 responses response NNS cord-015021-pol2qm74 6891 20 to to IN cord-015021-pol2qm74 6891 21 endotoxin endotoxin VB cord-015021-pol2qm74 6891 22 lipopolysaccharide lipopolysaccharide NN cord-015021-pol2qm74 6891 23 ( ( -LRB- cord-015021-pol2qm74 6891 24 LPS LPS NNP cord-015021-pol2qm74 6891 25 ) ) -RRB- cord-015021-pol2qm74 6891 26 in in IN cord-015021-pol2qm74 6891 27 the the DT cord-015021-pol2qm74 6891 28 rat rat NN cord-015021-pol2qm74 6891 29 . . . cord-015021-pol2qm74 6892 1 In in IN cord-015021-pol2qm74 6892 2 contrast contrast NN cord-015021-pol2qm74 6892 3 , , , cord-015021-pol2qm74 6892 4 LEH LEH NNP cord-015021-pol2qm74 6892 5 exacerbated exacerbate VBD cord-015021-pol2qm74 6892 6 the the DT cord-015021-pol2qm74 6892 7 LPS LPS NNP cord-015021-pol2qm74 6892 8 - - HYPH cord-015021-pol2qm74 6892 9 induced induce VBN cord-015021-pol2qm74 6892 10 TNFa TNFa NNP cord-015021-pol2qm74 6892 11 production production NN cord-015021-pol2qm74 6892 12 and and CC cord-015021-pol2qm74 6892 13 early early JJ cord-015021-pol2qm74 6892 14 mortality mortality NN cord-015021-pol2qm74 6892 15 . . . cord-015021-pol2qm74 6893 1 The the DT cord-015021-pol2qm74 6893 2 exacerbation exacerbation NN cord-015021-pol2qm74 6893 3 of of IN cord-015021-pol2qm74 6893 4 early early JJ cord-015021-pol2qm74 6893 5 mortality mortality NN cord-015021-pol2qm74 6893 6 by by IN cord-015021-pol2qm74 6893 7 LEH LEH NNP cord-015021-pol2qm74 6893 8 was be VBD cord-015021-pol2qm74 6893 9 attenuated attenuate VBN cord-015021-pol2qm74 6893 10 by by IN cord-015021-pol2qm74 6893 11 pretreatment pretreatment NN cord-015021-pol2qm74 6893 12 with with IN cord-015021-pol2qm74 6893 13 the the DT cord-015021-pol2qm74 6893 14 TNFu TNFu NNP cord-015021-pol2qm74 6893 15 synthesis synthesis NN cord-015021-pol2qm74 6893 16 inhibitor inhibitor NN cord-015021-pol2qm74 6893 17 rolipram rolipram NNP cord-015021-pol2qm74 6893 18 . . . cord-015021-pol2qm74 6894 1 Ex Ex NNP cord-015021-pol2qm74 6894 2 vivo vivo NN cord-015021-pol2qm74 6894 3 , , , cord-015021-pol2qm74 6894 4 peritoneal peritoneal JJ cord-015021-pol2qm74 6894 5 macrophages macrophage NNS cord-015021-pol2qm74 6894 6 from from IN cord-015021-pol2qm74 6894 7 rats rat NNS cord-015021-pol2qm74 6894 8 treated treat VBN cord-015021-pol2qm74 6894 9 with with IN cord-015021-pol2qm74 6894 10 LEH LEH NNP cord-015021-pol2qm74 6894 11 and and CC cord-015021-pol2qm74 6894 12 LPS LPS NNP cord-015021-pol2qm74 6895 1 have have VBP cord-015021-pol2qm74 6895 2 shown show VBN cord-015021-pol2qm74 6895 3 increased increase VBN cord-015021-pol2qm74 6895 4 IL IL NNP cord-015021-pol2qm74 6895 5 - - HYPH cord-015021-pol2qm74 6895 6 lg lg NNP cord-015021-pol2qm74 6895 7 mRNA mRNA NNP cord-015021-pol2qm74 6895 8 signal signal NN cord-015021-pol2qm74 6895 9 as as IN cord-015021-pol2qm74 6895 10 compared compare VBN cord-015021-pol2qm74 6895 11 to to IN cord-015021-pol2qm74 6895 12 LPS LPS NNP cord-015021-pol2qm74 6895 13 alone alone RB cord-015021-pol2qm74 6895 14 . . . cord-015021-pol2qm74 6896 1 Also also RB cord-015021-pol2qm74 6896 2 , , , cord-015021-pol2qm74 6896 3 LEH LEH NNP cord-015021-pol2qm74 6896 4 increased increase VBD cord-015021-pol2qm74 6896 5 TNFtx tnftx DT cord-015021-pol2qm74 6896 6 production production NN cord-015021-pol2qm74 6896 7 by by IN cord-015021-pol2qm74 6896 8 peritoneal peritoneal JJ cord-015021-pol2qm74 6896 9 macrophages macrophage NNS cord-015021-pol2qm74 6896 10 in in IN cord-015021-pol2qm74 6896 11 response response NN cord-015021-pol2qm74 6896 12 to to IN cord-015021-pol2qm74 6896 13 LPS LPS NNP cord-015021-pol2qm74 6896 14 stimulation stimulation NN cord-015021-pol2qm74 6896 15 in in IN cord-015021-pol2qm74 6896 16 vitro vitro FW cord-015021-pol2qm74 6896 17 . . . cord-015021-pol2qm74 6897 1 Additionally additionally RB cord-015021-pol2qm74 6897 2 , , , cord-015021-pol2qm74 6897 3 recent recent JJ cord-015021-pol2qm74 6897 4 pilot pilot NN cord-015021-pol2qm74 6897 5 studies study NNS cord-015021-pol2qm74 6897 6 indicate indicate VBP cord-015021-pol2qm74 6897 7 that that IN cord-015021-pol2qm74 6897 8 LEH LEH NNP cord-015021-pol2qm74 6897 9 attenuates attenuate VBZ cord-015021-pol2qm74 6897 10 PMA PMA NNP cord-015021-pol2qm74 6897 11 - - HYPH cord-015021-pol2qm74 6897 12 induced induce VBN cord-015021-pol2qm74 6897 13 superoxide superoxide NN cord-015021-pol2qm74 6897 14 production production NN cord-015021-pol2qm74 6897 15 from from IN cord-015021-pol2qm74 6897 16 rat rat NN cord-015021-pol2qm74 6897 17 peritoneal peritoneal JJ cord-015021-pol2qm74 6897 18 macrophages macrophage NNS cord-015021-pol2qm74 6897 19 and and CC cord-015021-pol2qm74 6897 20 that that IN cord-015021-pol2qm74 6897 21 LEH LEH NNP cord-015021-pol2qm74 6897 22 augments augment VBZ cord-015021-pol2qm74 6897 23 fMLP fMLP VBN cord-015021-pol2qm74 6897 24 - - HYPH cord-015021-pol2qm74 6897 25 induced induce VBN cord-015021-pol2qm74 6897 26 migration migration NN cord-015021-pol2qm74 6897 27 of of IN cord-015021-pol2qm74 6897 28 human human JJ cord-015021-pol2qm74 6897 29 monocytes monocyte NNS cord-015021-pol2qm74 6897 30 . . . cord-015021-pol2qm74 6898 1 Taken take VBN cord-015021-pol2qm74 6898 2 together together RB cord-015021-pol2qm74 6898 3 , , , cord-015021-pol2qm74 6898 4 these these DT cord-015021-pol2qm74 6898 5 data datum NNS cord-015021-pol2qm74 6898 6 strongly strongly RB cord-015021-pol2qm74 6898 7 support support VBP cord-015021-pol2qm74 6898 8 possible possible JJ cord-015021-pol2qm74 6898 9 interactions interaction NNS cord-015021-pol2qm74 6898 10 of of IN cord-015021-pol2qm74 6898 11 LEH LEH NNP cord-015021-pol2qm74 6898 12 with with IN cord-015021-pol2qm74 6898 13 the the DT cord-015021-pol2qm74 6898 14 MPS MPS NNP cord-015021-pol2qm74 6898 15 and and CC cord-015021-pol2qm74 6898 16 therefore therefore RB cord-015021-pol2qm74 6898 17 the the DT cord-015021-pol2qm74 6898 18 nature nature NN cord-015021-pol2qm74 6898 19 of of IN cord-015021-pol2qm74 6898 20 such such JJ cord-015021-pol2qm74 6898 21 interactions interaction NNS cord-015021-pol2qm74 6898 22 should should MD cord-015021-pol2qm74 6898 23 be be VB cord-015021-pol2qm74 6898 24 further further RB cord-015021-pol2qm74 6898 25 explored explore VBN cord-015021-pol2qm74 6898 26 . . . cord-015021-pol2qm74 6899 1 Over over IN cord-015021-pol2qm74 6899 2 the the DT cord-015021-pol2qm74 6899 3 last last JJ cord-015021-pol2qm74 6899 4 decade decade NN cord-015021-pol2qm74 6899 5 , , , cord-015021-pol2qm74 6899 6 we -PRON- PRP cord-015021-pol2qm74 6899 7 have have VBP cord-015021-pol2qm74 6899 8 developed develop VBN cord-015021-pol2qm74 6899 9 liposome liposome NN cord-015021-pol2qm74 6899 10 encapsulated encapsulate VBN cord-015021-pol2qm74 6899 11 hemoglobin hemoglobin NN cord-015021-pol2qm74 6899 12 ( ( -LRB- cord-015021-pol2qm74 6899 13 LEH LEH NNP cord-015021-pol2qm74 6899 14 ) ) -RRB- cord-015021-pol2qm74 6899 15 as as IN cord-015021-pol2qm74 6899 16 an an DT cord-015021-pol2qm74 6899 17 artificial artificial JJ cord-015021-pol2qm74 6899 18 oxygen oxygen NN cord-015021-pol2qm74 6899 19 carrying carrying NN cord-015021-pol2qm74 6899 20 fluid fluid NN cord-015021-pol2qm74 6899 21 , , , cord-015021-pol2qm74 6899 22 or or CC cord-015021-pol2qm74 6899 23 blood blood NN cord-015021-pol2qm74 6899 24 substitute substitute NN cord-015021-pol2qm74 6899 25 . . . cord-015021-pol2qm74 6900 1 Our -PRON- PRP$ cord-015021-pol2qm74 6900 2 efforts effort NNS cord-015021-pol2qm74 6900 3 have have VBP cord-015021-pol2qm74 6900 4 focused focus VBN cord-015021-pol2qm74 6900 5 on on IN cord-015021-pol2qm74 6900 6 studies study NNS cord-015021-pol2qm74 6900 7 to to TO cord-015021-pol2qm74 6900 8 define define VB cord-015021-pol2qm74 6900 9 the the DT cord-015021-pol2qm74 6900 10 safety safety NN cord-015021-pol2qm74 6900 11 and and CC cord-015021-pol2qm74 6900 12 efficacy efficacy NN cord-015021-pol2qm74 6900 13 of of IN cord-015021-pol2qm74 6900 14 this this DT cord-015021-pol2qm74 6900 15 resuscitative resuscitative JJ cord-015021-pol2qm74 6900 16 solutions solution NNS cord-015021-pol2qm74 6900 17 . . . cord-015021-pol2qm74 6901 1 LEH LEH NNP cord-015021-pol2qm74 6901 2 consists consist VBZ cord-015021-pol2qm74 6901 3 of of IN cord-015021-pol2qm74 6901 4 distearoyl distearoyl NNP cord-015021-pol2qm74 6901 5 phosphatidylcholine phosphatidylcholine NN cord-015021-pol2qm74 6901 6 , , , cord-015021-pol2qm74 6901 7 cholesterol cholesterol NN cord-015021-pol2qm74 6901 8 , , , cord-015021-pol2qm74 6901 9 dimyristoyl dimyristoyl NNP cord-015021-pol2qm74 6901 10 phosphatidylglyeerol phosphatidylglyeerol NNP cord-015021-pol2qm74 6901 11 , , , cord-015021-pol2qm74 6901 12 and and CC cord-015021-pol2qm74 6901 13 alpha alpha NN cord-015021-pol2qm74 6901 14 tocopherol tocopherol NN cord-015021-pol2qm74 6901 15 in in IN cord-015021-pol2qm74 6901 16 a a DT cord-015021-pol2qm74 6901 17 10:9:0.9:0.1 10:9:0.9:0.1 CD cord-015021-pol2qm74 6901 18 mole mole NN cord-015021-pol2qm74 6901 19 ratio ratio NN cord-015021-pol2qm74 6901 20 and and CC cord-015021-pol2qm74 6901 21 can can MD cord-015021-pol2qm74 6901 22 encapsulate encapsulate VB cord-015021-pol2qm74 6901 23 hemoglobins hemoglobin NNS cord-015021-pol2qm74 6901 24 of of IN cord-015021-pol2qm74 6901 25 different different JJ cord-015021-pol2qm74 6901 26 origin origin NN cord-015021-pol2qm74 6901 27 ( ( -LRB- cord-015021-pol2qm74 6901 28 bovine bovine JJ cord-015021-pol2qm74 6901 29 , , , cord-015021-pol2qm74 6901 30 human human JJ cord-015021-pol2qm74 6901 31 , , , cord-015021-pol2qm74 6901 32 recombinant recombinant JJ cord-015021-pol2qm74 6901 33 human human NN cord-015021-pol2qm74 6901 34 ) ) -RRB- cord-015021-pol2qm74 6901 35 . . . cord-015021-pol2qm74 6902 1 LEH LEH NNP cord-015021-pol2qm74 6902 2 is be VBZ cord-015021-pol2qm74 6902 3 fabricated fabricate VBN cord-015021-pol2qm74 6902 4 using use VBG cord-015021-pol2qm74 6902 5 hydrodynamic hydrodynamic JJ cord-015021-pol2qm74 6902 6 shear shear NN cord-015021-pol2qm74 6902 7 to to TO cord-015021-pol2qm74 6902 8 create create VB cord-015021-pol2qm74 6902 9 an an DT cord-015021-pol2qm74 6902 10 average average JJ cord-015021-pol2qm74 6902 11 particle particle NN cord-015021-pol2qm74 6902 12 size size NN cord-015021-pol2qm74 6902 13 of of IN cord-015021-pol2qm74 6902 14 0.3 0.3 CD cord-015021-pol2qm74 6902 15 microns micron NNS cord-015021-pol2qm74 6902 16 . . . cord-015021-pol2qm74 6903 1 LEH LEH NNP cord-015021-pol2qm74 6903 2 can can MD cord-015021-pol2qm74 6903 3 be be VB cord-015021-pol2qm74 6903 4 lyophilized lyophilize VBN cord-015021-pol2qm74 6903 5 using use VBG cord-015021-pol2qm74 6903 6 disaccharides disaccharide NNS cord-015021-pol2qm74 6903 7 and and CC cord-015021-pol2qm74 6903 8 stabilized stabilize VBN cord-015021-pol2qm74 6903 9 in in IN cord-015021-pol2qm74 6903 10 the the DT cord-015021-pol2qm74 6903 11 dry dry JJ cord-015021-pol2qm74 6903 12 state state NN cord-015021-pol2qm74 6903 13 and and CC cord-015021-pol2qm74 6903 14 easily easily RB cord-015021-pol2qm74 6903 15 reconstituted reconstitute VBN cord-015021-pol2qm74 6903 16 before before IN cord-015021-pol2qm74 6903 17 administration administration NN cord-015021-pol2qm74 6903 18 . . . cord-015021-pol2qm74 6904 1 Histopathology Histopathology NNP cord-015021-pol2qm74 6904 2 and and CC cord-015021-pol2qm74 6904 3 clinical clinical JJ cord-015021-pol2qm74 6904 4 chemistries chemistry NNS cord-015021-pol2qm74 6904 5 indicate indicate VBP cord-015021-pol2qm74 6904 6 that that IN cord-015021-pol2qm74 6904 7 LEH LEH NNP cord-015021-pol2qm74 6904 8 rapidly rapidly RB cord-015021-pol2qm74 6904 9 accumulates accumulate VBZ cord-015021-pol2qm74 6904 10 in in IN cord-015021-pol2qm74 6904 11 tissue tissue NN cord-015021-pol2qm74 6904 12 resident resident NN cord-015021-pol2qm74 6904 13 macrophages macrophage NNS cord-015021-pol2qm74 6904 14 in in IN cord-015021-pol2qm74 6904 15 small small JJ cord-015021-pol2qm74 6904 16 animals animal NNS cord-015021-pol2qm74 6904 17 injected inject VBN cord-015021-pol2qm74 6904 18 in in IN cord-015021-pol2qm74 6904 19 the the DT cord-015021-pol2qm74 6904 20 tail tail NN cord-015021-pol2qm74 6904 21 vein vein NN cord-015021-pol2qm74 6904 22 , , , cord-015021-pol2qm74 6904 23 principaI1y principaI1y '' cord-015021-pol2qm74 6904 24 in in IN cord-015021-pol2qm74 6904 25 the the DT cord-015021-pol2qm74 6904 26 liver liver NN cord-015021-pol2qm74 6904 27 and and CC cord-015021-pol2qm74 6904 28 spleen spleen NNS cord-015021-pol2qm74 6904 29 . . . cord-015021-pol2qm74 6905 1 The the DT cord-015021-pol2qm74 6905 2 consequences consequence NNS cord-015021-pol2qm74 6905 3 of of IN cord-015021-pol2qm74 6905 4 accumulation accumulation NN cord-015021-pol2qm74 6905 5 in in IN cord-015021-pol2qm74 6905 6 the the DT cord-015021-pol2qm74 6905 7 reticuloendothelial reticuloendothelial JJ cord-015021-pol2qm74 6905 8 system system NN cord-015021-pol2qm74 6905 9 are be VBP cord-015021-pol2qm74 6905 10 manifest manifest JJ cord-015021-pol2qm74 6905 11 by by IN cord-015021-pol2qm74 6905 12 transient transient JJ cord-015021-pol2qm74 6905 13 increases increase NNS cord-015021-pol2qm74 6905 14 in in IN cord-015021-pol2qm74 6905 15 liver liver NN cord-015021-pol2qm74 6905 16 transaminases transaminase NNS cord-015021-pol2qm74 6905 17 ( ( -LRB- cord-015021-pol2qm74 6905 18 AST AST NNP cord-015021-pol2qm74 6905 19 , , , cord-015021-pol2qm74 6905 20 ALT ALT NNP cord-015021-pol2qm74 6905 21 ) ) -RRB- cord-015021-pol2qm74 6905 22 , , , cord-015021-pol2qm74 6905 23 bilirubin bilirubin NN cord-015021-pol2qm74 6905 24 , , , cord-015021-pol2qm74 6905 25 and and CC cord-015021-pol2qm74 6905 26 BUN bun NN cord-015021-pol2qm74 6905 27 over over IN cord-015021-pol2qm74 6905 28 24 24 CD cord-015021-pol2qm74 6905 29 - - SYM cord-015021-pol2qm74 6905 30 48 48 CD cord-015021-pol2qm74 6905 31 hours hour NNS cord-015021-pol2qm74 6905 32 with with IN cord-015021-pol2qm74 6905 33 no no DT cord-015021-pol2qm74 6905 34 change change NN cord-015021-pol2qm74 6905 35 in in IN cord-015021-pol2qm74 6905 36 biliary biliary JJ cord-015021-pol2qm74 6905 37 function function NN cord-015021-pol2qm74 6905 38 ( ( -LRB- cord-015021-pol2qm74 6905 39 GGT GGT NNP cord-015021-pol2qm74 6905 40 , , , cord-015021-pol2qm74 6905 41 aP aP NNP cord-015021-pol2qm74 6905 42 ) ) -RRB- cord-015021-pol2qm74 6905 43 . . . cord-015021-pol2qm74 6906 1 Clearance clearance NN cord-015021-pol2qm74 6906 2 through through IN cord-015021-pol2qm74 6906 3 the the DT cord-015021-pol2qm74 6906 4 liver liver NN cord-015021-pol2qm74 6906 5 and and CC cord-015021-pol2qm74 6906 6 spleen spleen NN cord-015021-pol2qm74 6906 7 is be VBZ cord-015021-pol2qm74 6906 8 observed observe VBN cord-015021-pol2qm74 6906 9 over over IN cord-015021-pol2qm74 6906 10 the the DT cord-015021-pol2qm74 6906 11 course course NN cord-015021-pol2qm74 6906 12 of of IN cord-015021-pol2qm74 6906 13 1 1 CD cord-015021-pol2qm74 6906 14 - - SYM cord-015021-pol2qm74 6906 15 2-weeks 2-weeks CD cord-015021-pol2qm74 6906 16 . . . cord-015021-pol2qm74 6907 1 More More JJR cord-015021-pol2qm74 6907 2 recent recent JJ cord-015021-pol2qm74 6907 3 attention attention NN cord-015021-pol2qm74 6907 4 has have VBZ cord-015021-pol2qm74 6907 5 been be VBN cord-015021-pol2qm74 6907 6 focused focus VBN cord-015021-pol2qm74 6907 7 on on IN cord-015021-pol2qm74 6907 8 secondary secondary JJ cord-015021-pol2qm74 6907 9 consequences consequence NNS cord-015021-pol2qm74 6907 10 of of IN cord-015021-pol2qm74 6907 11 LEH LEH NNP cord-015021-pol2qm74 6907 12 administration administration NN cord-015021-pol2qm74 6907 13 especially especially RB cord-015021-pol2qm74 6907 14 with with IN cord-015021-pol2qm74 6907 15 regard regard NN cord-015021-pol2qm74 6907 16 to to IN cord-015021-pol2qm74 6907 17 inflammatory inflammatory JJ cord-015021-pol2qm74 6907 18 eytokines eytokine NNS cord-015021-pol2qm74 6907 19 . . . cord-015021-pol2qm74 6908 1 LEH LEH NNP cord-015021-pol2qm74 6908 2 does do VBZ cord-015021-pol2qm74 6908 3 not not RB cord-015021-pol2qm74 6908 4 elicit elicit VB cord-015021-pol2qm74 6908 5 expression expression NN cord-015021-pol2qm74 6908 6 of of IN cord-015021-pol2qm74 6908 7 tumor tumor NN cord-015021-pol2qm74 6908 8 necrosis necrosis NN cord-015021-pol2qm74 6908 9 factor factor NN cord-015021-pol2qm74 6908 10 in in IN cord-015021-pol2qm74 6908 11 vivo vivo NN cord-015021-pol2qm74 6908 12 and and CC cord-015021-pol2qm74 6908 13 in in IN cord-015021-pol2qm74 6908 14 isolated isolate VBN cord-015021-pol2qm74 6908 15 macrophage macrophage NN cord-015021-pol2qm74 6908 16 cultures culture NNS cord-015021-pol2qm74 6908 17 , , , cord-015021-pol2qm74 6908 18 but but CC cord-015021-pol2qm74 6908 19 does do VBZ cord-015021-pol2qm74 6908 20 result result VB cord-015021-pol2qm74 6908 21 in in IN cord-015021-pol2qm74 6908 22 a a DT cord-015021-pol2qm74 6908 23 transient transient JJ cord-015021-pol2qm74 6908 24 increase increase NN cord-015021-pol2qm74 6908 25 in in IN cord-015021-pol2qm74 6908 26 serum serum NN cord-015021-pol2qm74 6908 27 IL-6 IL-6 NNP cord-015021-pol2qm74 6908 28 . . . cord-015021-pol2qm74 6909 1 We -PRON- PRP cord-015021-pol2qm74 6909 2 have have VBP cord-015021-pol2qm74 6909 3 also also RB cord-015021-pol2qm74 6909 4 examined examine VBN cord-015021-pol2qm74 6909 5 the the DT cord-015021-pol2qm74 6909 6 interaction interaction NN cord-015021-pol2qm74 6909 7 of of IN cord-015021-pol2qm74 6909 8 LEH LEH NNP cord-015021-pol2qm74 6909 9 with with IN cord-015021-pol2qm74 6909 10 LPS LPS NNP cord-015021-pol2qm74 6909 11 in in IN cord-015021-pol2qm74 6909 12 vitro vitro FW cord-015021-pol2qm74 6909 13 macrophage macrophage NN cord-015021-pol2qm74 6909 14 culture culture NN cord-015021-pol2qm74 6909 15 to to TO cord-015021-pol2qm74 6909 16 further further RB cord-015021-pol2qm74 6909 17 understand understand VB cord-015021-pol2qm74 6909 18 how how WRB cord-015021-pol2qm74 6909 19 this this DT cord-015021-pol2qm74 6909 20 blood blood NN cord-015021-pol2qm74 6909 21 substitute substitute NN cord-015021-pol2qm74 6909 22 may may MD cord-015021-pol2qm74 6909 23 effect effect VB cord-015021-pol2qm74 6909 24 the the DT cord-015021-pol2qm74 6909 25 immune immune JJ cord-015021-pol2qm74 6909 26 system system NN cord-015021-pol2qm74 6909 27 . . . cord-015021-pol2qm74 6910 1 We -PRON- PRP cord-015021-pol2qm74 6910 2 have have VBP cord-015021-pol2qm74 6910 3 labeled label VBN cord-015021-pol2qm74 6910 4 LEH LEH NNP cord-015021-pol2qm74 6910 5 with with IN cord-015021-pol2qm74 6910 6 technetium-99 technetium-99 NN cord-015021-pol2qm74 6910 7 m m NN cord-015021-pol2qm74 6910 8 ( ( -LRB- cord-015021-pol2qm74 6910 9 99mTc 99mtc NN cord-015021-pol2qm74 6910 10 ) ) -RRB- cord-015021-pol2qm74 6910 11 to to TO cord-015021-pol2qm74 6910 12 study study VB cord-015021-pol2qm74 6910 13 the the DT cord-015021-pol2qm74 6910 14 biodistribution biodistribution NN cord-015021-pol2qm74 6910 15 of of IN cord-015021-pol2qm74 6910 16 LEH LEH NNP cord-015021-pol2qm74 6910 17 non non NNP cord-015021-pol2qm74 6910 18 - - VBZ cord-015021-pol2qm74 6910 19 invasively invasively RB cord-015021-pol2qm74 6910 20 in in IN cord-015021-pol2qm74 6910 21 anesthetized anesthetize VBN cord-015021-pol2qm74 6910 22 rabbits rabbit NNS cord-015021-pol2qm74 6910 23 . . . cord-015021-pol2qm74 6911 1 Rabbits rabbit NNS cord-015021-pol2qm74 6911 2 were be VBD cord-015021-pol2qm74 6911 3 infused infuse VBN cord-015021-pol2qm74 6911 4 with with IN cord-015021-pol2qm74 6911 5 a a DT cord-015021-pol2qm74 6911 6 25 25 CD cord-015021-pol2qm74 6911 7 % % NN cord-015021-pol2qm74 6911 8 topload topload NN cord-015021-pol2qm74 6911 9 of of IN cord-015021-pol2qm74 6911 10 LEH LEH NNP cord-015021-pol2qm74 6911 11 ( ( -LRB- cord-015021-pol2qm74 6911 12 200 200 CD cord-015021-pol2qm74 6911 13 mg mg NN cord-015021-pol2qm74 6911 14 of of IN cord-015021-pol2qm74 6911 15 phospholipid phospholipid NN cord-015021-pol2qm74 6911 16 , , , cord-015021-pol2qm74 6911 17 2.5 2.5 CD cord-015021-pol2qm74 6911 18 g g NN cord-015021-pol2qm74 6911 19 of of IN cord-015021-pol2qm74 6911 20 hemoglobin hemoglobin NN cord-015021-pol2qm74 6911 21 per per IN cord-015021-pol2qm74 6911 22 kg kg NNS cord-015021-pol2qm74 6911 23 of of IN cord-015021-pol2qm74 6911 24 body body NN cord-015021-pol2qm74 6911 25 weight weight NN cord-015021-pol2qm74 6911 26 ) ) -RRB- cord-015021-pol2qm74 6911 27 and and CC cord-015021-pol2qm74 6911 28 imaged image VBD cord-015021-pol2qm74 6911 29 continuously continuously RB cord-015021-pol2qm74 6911 30 with with IN cord-015021-pol2qm74 6911 31 a a DT cord-015021-pol2qm74 6911 32 gamma gamma JJ cord-015021-pol2qm74 6911 33 camera camera NN cord-015021-pol2qm74 6911 34 . . . cord-015021-pol2qm74 6912 1 At at IN cord-015021-pol2qm74 6912 2 20 20 CD cord-015021-pol2qm74 6912 3 hours hour NNS cord-015021-pol2qm74 6912 4 , , , cord-015021-pol2qm74 6912 5 images image NNS cord-015021-pol2qm74 6912 6 were be VBD cord-015021-pol2qm74 6912 7 again again RB cord-015021-pol2qm74 6912 8 acquired acquire VBN cord-015021-pol2qm74 6912 9 . . . cord-015021-pol2qm74 6913 1 Animals animal NNS cord-015021-pol2qm74 6913 2 were be VBD cord-015021-pol2qm74 6913 3 then then RB cord-015021-pol2qm74 6913 4 sacrificed sacrifice VBN cord-015021-pol2qm74 6913 5 and and CC cord-015021-pol2qm74 6913 6 tissue tissue NN cord-015021-pol2qm74 6913 7 counts count NNS cord-015021-pol2qm74 6913 8 obtained obtain VBN cord-015021-pol2qm74 6913 9 , , , cord-015021-pol2qm74 6913 10 images image NNS cord-015021-pol2qm74 6913 11 revealed reveal VBD cord-015021-pol2qm74 6913 12 an an DT cord-015021-pol2qm74 6913 13 initial initial JJ cord-015021-pol2qm74 6913 14 rapid rapid JJ cord-015021-pol2qm74 6913 15 uptake uptake NN cord-015021-pol2qm74 6913 16 bythe bythe DT cord-015021-pol2qm74 6913 17 liver liver NN cord-015021-pol2qm74 6913 18 , , , cord-015021-pol2qm74 6913 19 8 8 CD cord-015021-pol2qm74 6913 20 % % NN cord-015021-pol2qm74 6913 21 at at IN cord-015021-pol2qm74 6913 22 30 30 CD cord-015021-pol2qm74 6913 23 minutes minute NNS cord-015021-pol2qm74 6913 24 and and CC cord-015021-pol2qm74 6913 25 15 15 CD cord-015021-pol2qm74 6913 26 % % NN cord-015021-pol2qm74 6913 27 by by IN cord-015021-pol2qm74 6913 28 2 2 CD cord-015021-pol2qm74 6913 29 hours hour NNS cord-015021-pol2qm74 6913 30 . . . cord-015021-pol2qm74 6914 1 The the DT cord-015021-pol2qm74 6914 2 spleen spleen NN cord-015021-pol2qm74 6914 3 accumulated accumulate VBN cord-015021-pol2qm74 6914 4 activity activity NN cord-015021-pol2qm74 6914 5 at at IN cord-015021-pol2qm74 6914 6 a a DT cord-015021-pol2qm74 6914 7 slower slow JJR cord-015021-pol2qm74 6914 8 rate rate NN cord-015021-pol2qm74 6914 9 , , , cord-015021-pol2qm74 6914 10 3 3 CD cord-015021-pol2qm74 6914 11 % % NN cord-015021-pol2qm74 6914 12 at at IN cord-015021-pol2qm74 6914 13 30 30 CD cord-015021-pol2qm74 6914 14 minutes minute NNS cord-015021-pol2qm74 6914 15 and and CC cord-015021-pol2qm74 6914 16 7 7 CD cord-015021-pol2qm74 6914 17 % % NN cord-015021-pol2qm74 6914 18 at at IN cord-015021-pol2qm74 6914 19 2 2 CD cord-015021-pol2qm74 6914 20 hours hour NNS cord-015021-pol2qm74 6914 21 . . . cord-015021-pol2qm74 6915 1 At at IN cord-015021-pol2qm74 6915 2 20 20 CD cord-015021-pol2qm74 6915 3 hours hour NNS cord-015021-pol2qm74 6915 4 , , , cord-015021-pol2qm74 6915 5 autopsy autopsy JJ cord-015021-pol2qm74 6915 6 biodistribution biodistribution NN cord-015021-pol2qm74 6915 7 studies study NNS cord-015021-pol2qm74 6915 8 revealed reveal VBD cord-015021-pol2qm74 6915 9 that that IN cord-015021-pol2qm74 6915 10 approximately approximately RB cord-015021-pol2qm74 6915 11 42.6 42.6 CD cord-015021-pol2qm74 6915 12 % % NN cord-015021-pol2qm74 6915 13 of of IN cord-015021-pol2qm74 6915 14 the the DT cord-015021-pol2qm74 6915 15 dose dose NN cord-015021-pol2qm74 6915 16 is be VBZ cord-015021-pol2qm74 6915 17 in in IN cord-015021-pol2qm74 6915 18 the the DT cord-015021-pol2qm74 6915 19 blood blood NN cord-015021-pol2qm74 6915 20 pool pool NN cord-015021-pol2qm74 6915 21 , , , cord-015021-pol2qm74 6915 22 15.4 15.4 CD cord-015021-pol2qm74 6915 23 % % NN cord-015021-pol2qm74 6915 24 in in IN cord-015021-pol2qm74 6915 25 liver liver NN cord-015021-pol2qm74 6915 26 , , , cord-015021-pol2qm74 6915 27 18.1 18.1 CD cord-015021-pol2qm74 6915 28 % % NN cord-015021-pol2qm74 6915 29 in in IN cord-015021-pol2qm74 6915 30 spleen spleen NN cord-015021-pol2qm74 6915 31 , , , cord-015021-pol2qm74 6915 32 3.2 3.2 CD cord-015021-pol2qm74 6915 33 % % NN cord-015021-pol2qm74 6915 34 in in IN cord-015021-pol2qm74 6915 35 lungs lung NNS cord-015021-pol2qm74 6915 36 , , , cord-015021-pol2qm74 6915 37 2.4 2.4 CD cord-015021-pol2qm74 6915 38 % % NN cord-015021-pol2qm74 6915 39 in in IN cord-015021-pol2qm74 6915 40 muscle muscle NN cord-015021-pol2qm74 6915 41 and and CC cord-015021-pol2qm74 6915 42 1.6 1.6 CD cord-015021-pol2qm74 6915 43 % % NN cord-015021-pol2qm74 6915 44 in in IN cord-015021-pol2qm74 6915 45 urine urine NN cord-015021-pol2qm74 6915 46 , , , cord-015021-pol2qm74 6915 47 with with IN cord-015021-pol2qm74 6915 48 trace trace NN cord-015021-pol2qm74 6915 49 levels level NNS cord-015021-pol2qm74 6915 50 in in IN cord-015021-pol2qm74 6915 51 kidney kidney NN cord-015021-pol2qm74 6915 52 , , , cord-015021-pol2qm74 6915 53 brain brain NN cord-015021-pol2qm74 6915 54 and and CC cord-015021-pol2qm74 6915 55 heart heart NN cord-015021-pol2qm74 6915 56 ( ( -LRB- cord-015021-pol2qm74 6915 57 < < NNP cord-015021-pol2qm74 6915 58 1 1 CD cord-015021-pol2qm74 6915 59 ° ° NN cord-015021-pol2qm74 6915 60 /o /o NNP cord-015021-pol2qm74 6915 61 ) ) -RRB- cord-015021-pol2qm74 6915 62 . . . cord-015021-pol2qm74 6916 1 In in IN cord-015021-pol2qm74 6916 2 a a DT cord-015021-pol2qm74 6916 3 hypovolemic hypovolemic JJ cord-015021-pol2qm74 6916 4 model model NN cord-015021-pol2qm74 6916 5 , , , cord-015021-pol2qm74 6916 6 rats rat NNS cord-015021-pol2qm74 6916 7 were be VBD cord-015021-pol2qm74 6916 8 10 10 CD cord-015021-pol2qm74 6916 9 % % NN cord-015021-pol2qm74 6916 10 or or CC cord-015021-pol2qm74 6916 11 50 50 CD cord-015021-pol2qm74 6916 12 % % NN cord-015021-pol2qm74 6916 13 exchange exchange NN cord-015021-pol2qm74 6916 14 transfused transfuse VBN cord-015021-pol2qm74 6916 15 with with IN cord-015021-pol2qm74 6916 16 99mTc 99mTc NNP cord-015021-pol2qm74 6916 17 - - HYPH cord-015021-pol2qm74 6916 18 LEH leh NN cord-015021-pol2qm74 6916 19 . . . cord-015021-pol2qm74 6917 1 In in IN cord-015021-pol2qm74 6917 2 the the DT cord-015021-pol2qm74 6917 3 10 10 CD cord-015021-pol2qm74 6917 4 % % NN cord-015021-pol2qm74 6917 5 exchange exchange NN cord-015021-pol2qm74 6917 6 model model NN cord-015021-pol2qm74 6917 7 , , , cord-015021-pol2qm74 6917 8 99mTc 99mTc NNP cord-015021-pol2qm74 6917 9 - - HYPH cord-015021-pol2qm74 6917 10 LEH LEH NNP cord-015021-pol2qm74 6917 11 was be VBD cord-015021-pol2qm74 6917 12 rapidly rapidly RB cord-015021-pol2qm74 6917 13 taken take VBN cord-015021-pol2qm74 6917 14 up up RP cord-015021-pol2qm74 6917 15 by by IN cord-015021-pol2qm74 6917 16 the the DT cord-015021-pol2qm74 6917 17 liver liver NN cord-015021-pol2qm74 6917 18 and and CC cord-015021-pol2qm74 6917 19 spleen spleen NNS cord-015021-pol2qm74 6917 20 with with IN cord-015021-pol2qm74 6917 21 minimal minimal JJ cord-015021-pol2qm74 6917 22 activity activity NN cord-015021-pol2qm74 6917 23 in in IN cord-015021-pol2qm74 6917 24 the the DT cord-015021-pol2qm74 6917 25 circulation circulation NN cord-015021-pol2qm74 6917 26 at at IN cord-015021-pol2qm74 6917 27 20 20 CD cord-015021-pol2qm74 6917 28 hours hour NNS cord-015021-pol2qm74 6917 29 . . . cord-015021-pol2qm74 6918 1 With with IN cord-015021-pol2qm74 6918 2 the the DT cord-015021-pol2qm74 6918 3 50 50 CD cord-015021-pol2qm74 6918 4 % % NN cord-015021-pol2qm74 6918 5 exchange exchange NN cord-015021-pol2qm74 6918 6 , , , cord-015021-pol2qm74 6918 7 50 50 CD cord-015021-pol2qm74 6918 8 % % NN cord-015021-pol2qm74 6918 9 of of IN cord-015021-pol2qm74 6918 10 the the DT cord-015021-pol2qm74 6918 11 LEH LEH NNP cord-015021-pol2qm74 6918 12 was be VBD cord-015021-pol2qm74 6918 13 in in IN cord-015021-pol2qm74 6918 14 circulation circulation NN cord-015021-pol2qm74 6918 15 at at IN cord-015021-pol2qm74 6918 16 20 20 CD cord-015021-pol2qm74 6918 17 hours hour NNS cord-015021-pol2qm74 6918 18 . . . cord-015021-pol2qm74 6919 1 The the DT cord-015021-pol2qm74 6919 2 interaction interaction NN cord-015021-pol2qm74 6919 3 of of IN cord-015021-pol2qm74 6919 4 LEH LEH NNP cord-015021-pol2qm74 6919 5 with with IN cord-015021-pol2qm74 6919 6 platelets platelet NNS cord-015021-pol2qm74 6919 7 labeled label VBN cord-015021-pol2qm74 6919 8 with with IN cord-015021-pol2qm74 6919 9 indium-111 indium-111 NNP cord-015021-pol2qm74 6919 10 was be VBD cord-015021-pol2qm74 6919 11 also also RB cord-015021-pol2qm74 6919 12 studied study VBN cord-015021-pol2qm74 6919 13 . . . cord-015021-pol2qm74 6920 1 After after IN cord-015021-pol2qm74 6920 2 infusion infusion NN cord-015021-pol2qm74 6920 3 of of IN cord-015021-pol2qm74 6920 4 LEH LEH NNP cord-015021-pol2qm74 6920 5 , , , cord-015021-pol2qm74 6920 6 the the DT cord-015021-pol2qm74 6920 7 labeled label VBN cord-015021-pol2qm74 6920 8 platelets platelet NNS cord-015021-pol2qm74 6920 9 rapidly rapidly RB cord-015021-pol2qm74 6920 10 moved move VBD cord-015021-pol2qm74 6920 11 from from IN cord-015021-pol2qm74 6920 12 the the DT cord-015021-pol2qm74 6920 13 circulation circulation NN cord-015021-pol2qm74 6920 14 to to IN cord-015021-pol2qm74 6920 15 the the DT cord-015021-pol2qm74 6920 16 lungs lung NNS cord-015021-pol2qm74 6920 17 and and CC cord-015021-pol2qm74 6920 18 liver liver NN cord-015021-pol2qm74 6920 19 . . . cord-015021-pol2qm74 6921 1 Over over IN cord-015021-pol2qm74 6921 2 the the DT cord-015021-pol2qm74 6921 3 next next JJ cord-015021-pol2qm74 6921 4 30 30 CD cord-015021-pol2qm74 6921 5 minutes minute NNS cord-015021-pol2qm74 6921 6 , , , cord-015021-pol2qm74 6921 7 the the DT cord-015021-pol2qm74 6921 8 platelets platelet NNS cord-015021-pol2qm74 6921 9 gradually gradually RB cord-015021-pol2qm74 6921 10 returned return VBD cord-015021-pol2qm74 6921 11 to to IN cord-015021-pol2qm74 6921 12 circulation circulation NN cord-015021-pol2qm74 6921 13 . . . cord-015021-pol2qm74 6922 1 This this DT cord-015021-pol2qm74 6922 2 effect effect NN cord-015021-pol2qm74 6922 3 was be VBD cord-015021-pol2qm74 6922 4 not not RB cord-015021-pol2qm74 6922 5 seen see VBN cord-015021-pol2qm74 6922 6 with with IN cord-015021-pol2qm74 6922 7 Iiposomes Iiposomes NNP cord-015021-pol2qm74 6922 8 of of IN cord-015021-pol2qm74 6922 9 the the DT cord-015021-pol2qm74 6922 10 same same JJ cord-015021-pol2qm74 6922 11 lipid lipid NN cord-015021-pol2qm74 6922 12 composition composition NN cord-015021-pol2qm74 6922 13 but but CC cord-015021-pol2qm74 6922 14 containing contain VBG cord-015021-pol2qm74 6922 15 no no DT cord-015021-pol2qm74 6922 16 hemoglobin hemoglobin NN cord-015021-pol2qm74 6922 17 . . . cord-015021-pol2qm74 6923 1 Non non JJ cord-015021-pol2qm74 6923 2 - - JJ cord-015021-pol2qm74 6923 3 invasive invasive JJ cord-015021-pol2qm74 6923 4 imaging imaging NN cord-015021-pol2qm74 6923 5 is be VBZ cord-015021-pol2qm74 6923 6 proving prove VBG cord-015021-pol2qm74 6923 7 to to TO cord-015021-pol2qm74 6923 8 be be VB cord-015021-pol2qm74 6923 9 a a DT cord-015021-pol2qm74 6923 10 very very RB cord-015021-pol2qm74 6923 11 useful useful JJ cord-015021-pol2qm74 6923 12 tool tool NN cord-015021-pol2qm74 6923 13 for for IN cord-015021-pol2qm74 6923 14 the the DT cord-015021-pol2qm74 6923 15 investigation investigation NN cord-015021-pol2qm74 6923 16 of of IN cord-015021-pol2qm74 6923 17 LEH LEH NNP cord-015021-pol2qm74 6923 18 . . . cord-015021-pol2qm74 6924 1 The the DT cord-015021-pol2qm74 6924 2 need need NN cord-015021-pol2qm74 6924 3 for for IN cord-015021-pol2qm74 6924 4 a a DT cord-015021-pol2qm74 6924 5 safe safe JJ cord-015021-pol2qm74 6924 6 , , , cord-015021-pol2qm74 6924 7 efficacious efficacious JJ cord-015021-pol2qm74 6924 8 and and CC cord-015021-pol2qm74 6924 9 commercially commercially RB cord-015021-pol2qm74 6924 10 viable viable JJ cord-015021-pol2qm74 6924 11 blood blood NN cord-015021-pol2qm74 6924 12 substitute substitute NN cord-015021-pol2qm74 6924 13 is be VBZ cord-015021-pol2qm74 6924 14 unequivocal unequivocal JJ cord-015021-pol2qm74 6924 15 . . . cord-015021-pol2qm74 6925 1 Of of IN cord-015021-pol2qm74 6925 2 the the DT cord-015021-pol2qm74 6925 3 several several JJ cord-015021-pol2qm74 6925 4 strategies strategy NNS cord-015021-pol2qm74 6925 5 pursued pursue VBN cord-015021-pol2qm74 6925 6 to to TO cord-015021-pol2qm74 6925 7 invent invent VB cord-015021-pol2qm74 6925 8 an an DT cord-015021-pol2qm74 6925 9 adequate adequate JJ cord-015021-pol2qm74 6925 10 blood blood NN cord-015021-pol2qm74 6925 11 substitute substitute NN cord-015021-pol2qm74 6925 12 , , , cord-015021-pol2qm74 6925 13 Liposome liposome NN cord-015021-pol2qm74 6925 14 Entrapped entrap VBN cord-015021-pol2qm74 6925 15 Hemoglobin Hemoglobin NNP cord-015021-pol2qm74 6925 16 ( ( -LRB- cord-015021-pol2qm74 6925 17 LEH LEH NNP cord-015021-pol2qm74 6925 18 ) ) -RRB- cord-015021-pol2qm74 6925 19 has have VBZ cord-015021-pol2qm74 6925 20 been be VBN cord-015021-pol2qm74 6925 21 already already RB cord-015021-pol2qm74 6925 22 established establish VBN cord-015021-pol2qm74 6925 23 as as IN cord-015021-pol2qm74 6925 24 a a DT cord-015021-pol2qm74 6925 25 leading lead VBG cord-015021-pol2qm74 6925 26 possibility possibility NN cord-015021-pol2qm74 6925 27 . . . cord-015021-pol2qm74 6926 1 Major major JJ cord-015021-pol2qm74 6926 2 advances advance NNS cord-015021-pol2qm74 6926 3 in in IN cord-015021-pol2qm74 6926 4 liposome liposome NN cord-015021-pol2qm74 6926 5 technology technology NN cord-015021-pol2qm74 6926 6 have have VBP cord-015021-pol2qm74 6926 7 already already RB cord-015021-pol2qm74 6926 8 resulted result VBN cord-015021-pol2qm74 6926 9 in in IN cord-015021-pol2qm74 6926 10 liposome liposome NN cord-015021-pol2qm74 6926 11 preparations preparation NNS cord-015021-pol2qm74 6926 12 compatible compatible JJ cord-015021-pol2qm74 6926 13 with with IN cord-015021-pol2qm74 6926 14 clinical clinical JJ cord-015021-pol2qm74 6926 15 use use NN cord-015021-pol2qm74 6926 16 for for IN cord-015021-pol2qm74 6926 17 drug drug NN cord-015021-pol2qm74 6926 18 delivery delivery NN cord-015021-pol2qm74 6926 19 . . . cord-015021-pol2qm74 6927 1 Recent recent JJ cord-015021-pol2qm74 6927 2 technological technological JJ cord-015021-pol2qm74 6927 3 advances advance NNS cord-015021-pol2qm74 6927 4 made make VBN cord-015021-pol2qm74 6927 5 by by IN cord-015021-pol2qm74 6927 6 the the DT cord-015021-pol2qm74 6927 7 U.S. U.S. NNP cord-015021-pol2qm74 6927 8 Naval Naval NNP cord-015021-pol2qm74 6927 9 Research Research NNP cord-015021-pol2qm74 6927 10 Laboratories Laboratories NNP cord-015021-pol2qm74 6927 11 resulted result VBD cord-015021-pol2qm74 6927 12 in in IN cord-015021-pol2qm74 6927 13 the the DT cord-015021-pol2qm74 6927 14 capacity capacity NN cord-015021-pol2qm74 6927 15 to to TO cord-015021-pol2qm74 6927 16 entrap entrap VB cord-015021-pol2qm74 6927 17 hemoglobin hemoglobin NN cord-015021-pol2qm74 6927 18 into into IN cord-015021-pol2qm74 6927 19 liposomes liposome NNS cord-015021-pol2qm74 6927 20 in in IN cord-015021-pol2qm74 6927 21 a a DT cord-015021-pol2qm74 6927 22 way way NN cord-015021-pol2qm74 6927 23 which which WDT cord-015021-pol2qm74 6927 24 secludes seclude VBZ cord-015021-pol2qm74 6927 25 hemoglobin hemoglobin NN cord-015021-pol2qm74 6927 26 from from IN cord-015021-pol2qm74 6927 27 interacting interact VBG cord-015021-pol2qm74 6927 28 freely freely RB cord-015021-pol2qm74 6927 29 with with IN cord-015021-pol2qm74 6927 30 biological biological JJ cord-015021-pol2qm74 6927 31 systems system NNS cord-015021-pol2qm74 6927 32 . . . cord-015021-pol2qm74 6928 1 The the DT cord-015021-pol2qm74 6928 2 LEH LEH NNP cord-015021-pol2qm74 6928 3 produced produce VBD cord-015021-pol2qm74 6928 4 has have VBZ cord-015021-pol2qm74 6928 5 already already RB cord-015021-pol2qm74 6928 6 been be VBN cord-015021-pol2qm74 6928 7 tested test VBN cord-015021-pol2qm74 6928 8 in in RP cord-015021-pol2qm74 6928 9 in in IN cord-015021-pol2qm74 6928 10 vivo vivo NN cord-015021-pol2qm74 6928 11 systems system NNS cord-015021-pol2qm74 6928 12 and and CC cord-015021-pol2qm74 6928 13 was be VBD cord-015021-pol2qm74 6928 14 foun.d foun.d JJ cord-015021-pol2qm74 6928 15 to to TO cord-015021-pol2qm74 6928 16 be be VB cord-015021-pol2qm74 6928 17 well well RB cord-015021-pol2qm74 6928 18 tolerated tolerate VBN cord-015021-pol2qm74 6928 19 . . . cord-015021-pol2qm74 6929 1 Moreover moreover RB cord-015021-pol2qm74 6929 2 , , , cord-015021-pol2qm74 6929 3 the the DT cord-015021-pol2qm74 6929 4 LEH LEH NNP cord-015021-pol2qm74 6929 5 originally originally RB cord-015021-pol2qm74 6929 6 produced produce VBD cord-015021-pol2qm74 6929 7 as as IN cord-015021-pol2qm74 6929 8 a a DT cord-015021-pol2qm74 6929 9 solution solution NN cord-015021-pol2qm74 6929 10 can can MD cord-015021-pol2qm74 6929 11 be be VB cord-015021-pol2qm74 6929 12 transformed transform VBN cord-015021-pol2qm74 6929 13 into into IN cord-015021-pol2qm74 6929 14 a a DT cord-015021-pol2qm74 6929 15 lyophilized lyophilized JJ cord-015021-pol2qm74 6929 16 form form NN cord-015021-pol2qm74 6929 17 which which WDT cord-015021-pol2qm74 6929 18 can can MD cord-015021-pol2qm74 6929 19 be be VB cord-015021-pol2qm74 6929 20 reconstituted reconstitute VBN cord-015021-pol2qm74 6929 21 and and CC cord-015021-pol2qm74 6929 22 delivered deliver VBN cord-015021-pol2qm74 6929 23 as as IN cord-015021-pol2qm74 6929 24 a a DT cord-015021-pol2qm74 6929 25 fresh fresh JJ cord-015021-pol2qm74 6929 26 solution solution NN cord-015021-pol2qm74 6929 27 . . . cord-015021-pol2qm74 6930 1 While while IN cord-015021-pol2qm74 6930 2 important important JJ cord-015021-pol2qm74 6930 3 milestones milestone NNS cord-015021-pol2qm74 6930 4 in in IN cord-015021-pol2qm74 6930 5 LEH LEH NNP cord-015021-pol2qm74 6930 6 development development NN cord-015021-pol2qm74 6930 7 for for IN cord-015021-pol2qm74 6930 8 a a DT cord-015021-pol2qm74 6930 9 practical practical JJ cord-015021-pol2qm74 6930 10 blood blood NN cord-015021-pol2qm74 6930 11 substitute substitute NN cord-015021-pol2qm74 6930 12 have have VBP cord-015021-pol2qm74 6930 13 been be VBN cord-015021-pol2qm74 6930 14 achieved achieve VBN cord-015021-pol2qm74 6930 15 , , , cord-015021-pol2qm74 6930 16 several several JJ cord-015021-pol2qm74 6930 17 issues issue NNS cord-015021-pol2qm74 6930 18 remain remain VBP cord-015021-pol2qm74 6930 19 to to TO cord-015021-pol2qm74 6930 20 be be VB cord-015021-pol2qm74 6930 21 explored explore VBN cord-015021-pol2qm74 6930 22 . . . cord-015021-pol2qm74 6931 1 Most most RBS cord-015021-pol2qm74 6931 2 notably notably RB cord-015021-pol2qm74 6931 3 , , , cord-015021-pol2qm74 6931 4 the the DT cord-015021-pol2qm74 6931 5 long long JJ cord-015021-pol2qm74 6931 6 term term NN cord-015021-pol2qm74 6931 7 consequences consequence NNS cord-015021-pol2qm74 6931 8 of of IN cord-015021-pol2qm74 6931 9 LEH LEH NNP cord-015021-pol2qm74 6931 10 on on IN cord-015021-pol2qm74 6931 11 host host NN cord-015021-pol2qm74 6931 12 defense defense NN cord-015021-pol2qm74 6931 13 mechanisms mechanism NNS cord-015021-pol2qm74 6931 14 and and CC cord-015021-pol2qm74 6931 15 , , , cord-015021-pol2qm74 6931 16 in in IN cord-015021-pol2qm74 6931 17 particular particular JJ cord-015021-pol2qm74 6931 18 , , , cord-015021-pol2qm74 6931 19 immune immune JJ cord-015021-pol2qm74 6931 20 cell cell NN cord-015021-pol2qm74 6931 21 function function NN cord-015021-pol2qm74 6931 22 . . . cord-015021-pol2qm74 6932 1 In in IN cord-015021-pol2qm74 6932 2 addition addition NN cord-015021-pol2qm74 6932 3 , , , cord-015021-pol2qm74 6932 4 it -PRON- PRP cord-015021-pol2qm74 6932 5 is be VBZ cord-015021-pol2qm74 6932 6 important important JJ cord-015021-pol2qm74 6932 7 to to TO cord-015021-pol2qm74 6932 8 understand understand VB cord-015021-pol2qm74 6932 9 more more JJR cord-015021-pol2qm74 6932 10 fully fully RB cord-015021-pol2qm74 6932 11 the the DT cord-015021-pol2qm74 6932 12 metabolic metabolic JJ cord-015021-pol2qm74 6932 13 fate fate NN cord-015021-pol2qm74 6932 14 and and CC cord-015021-pol2qm74 6932 15 repercussions repercussion NNS cord-015021-pol2qm74 6932 16 of of IN cord-015021-pol2qm74 6932 17 LEH LEH NNP cord-015021-pol2qm74 6932 18 delivered deliver VBD cord-015021-pol2qm74 6932 19 at at IN cord-015021-pol2qm74 6932 20 clinically clinically RB cord-015021-pol2qm74 6932 21 relevant relevant JJ cord-015021-pol2qm74 6932 22 dose dose NN cord-015021-pol2qm74 6932 23 / / SYM cord-015021-pol2qm74 6932 24 schedule schedule NN cord-015021-pol2qm74 6932 25 regimens regimen NNS cord-015021-pol2qm74 6932 26 . . . cord-015021-pol2qm74 6933 1 Finally finally RB cord-015021-pol2qm74 6933 2 , , , cord-015021-pol2qm74 6933 3 while while IN cord-015021-pol2qm74 6933 4 LEH LEH NNP cord-015021-pol2qm74 6933 5 is be VBZ cord-015021-pol2qm74 6933 6 a a DT cord-015021-pol2qm74 6933 7 highly highly RB cord-015021-pol2qm74 6933 8 promising promising JJ cord-015021-pol2qm74 6933 9 strategy strategy NN cord-015021-pol2qm74 6933 10 for for IN cord-015021-pol2qm74 6933 11 a a DT cord-015021-pol2qm74 6933 12 blood blood NN cord-015021-pol2qm74 6933 13 substitute substitute NN cord-015021-pol2qm74 6933 14 , , , cord-015021-pol2qm74 6933 15 the the DT cord-015021-pol2qm74 6933 16 present present JJ cord-015021-pol2qm74 6933 17 formulations formulation NNS cord-015021-pol2qm74 6933 18 consist consist VBP cord-015021-pol2qm74 6933 19 of of IN cord-015021-pol2qm74 6933 20 human human JJ cord-015021-pol2qm74 6933 21 hemoglobin hemoglobin NN cord-015021-pol2qm74 6933 22 derived derive VBN cord-015021-pol2qm74 6933 23 from from IN cord-015021-pol2qm74 6933 24 human human JJ cord-015021-pol2qm74 6933 25 blood blood NN cord-015021-pol2qm74 6933 26 , , , cord-015021-pol2qm74 6933 27 To to TO cord-015021-pol2qm74 6933 28 improve improve VB cord-015021-pol2qm74 6933 29 the the DT cord-015021-pol2qm74 6933 30 safety safety NN cord-015021-pol2qm74 6933 31 profile profile NN cord-015021-pol2qm74 6933 32 , , , cord-015021-pol2qm74 6933 33 a a DT cord-015021-pol2qm74 6933 34 recombinant recombinant JJ cord-015021-pol2qm74 6933 35 preparation preparation NN cord-015021-pol2qm74 6933 36 for for IN cord-015021-pol2qm74 6933 37 liposome liposome NN cord-015021-pol2qm74 6933 38 entrapment entrapment NN cord-015021-pol2qm74 6933 39 will will MD cord-015021-pol2qm74 6933 40 be be VB cord-015021-pol2qm74 6933 41 much much RB cord-015021-pol2qm74 6933 42 desired desire VBN cord-015021-pol2qm74 6933 43 , , , cord-015021-pol2qm74 6933 44 Aa Aa NNP cord-015021-pol2qm74 6933 45 - - HYPH cord-015021-pol2qm74 6933 46 ginine ginine NNP cord-015021-pol2qm74 6933 47 , , , cord-015021-pol2qm74 6933 48 a a DT cord-015021-pol2qm74 6933 49 semi semi JJ cord-015021-pol2qm74 6933 50 - - JJ cord-015021-pol2qm74 6933 51 essendai essendai JJ cord-015021-pol2qm74 6933 52 dietary dietary JJ cord-015021-pol2qm74 6933 53 amino amino NN cord-015021-pol2qm74 6933 54 acid acid NN cord-015021-pol2qm74 6933 55 , , , cord-015021-pol2qm74 6933 56 possesses possess VBZ cord-015021-pol2qm74 6933 57 several several JJ cord-015021-pol2qm74 6933 58 unique unique JJ cord-015021-pol2qm74 6933 59 and and CC cord-015021-pol2qm74 6933 60 potentially potentially RB cord-015021-pol2qm74 6933 61 pharmacologic pharmacologic JJ cord-015021-pol2qm74 6933 62 properties property NNS cord-015021-pol2qm74 6933 63 . . . cord-015021-pol2qm74 6934 1 Argirdun Argirdun NNP cord-015021-pol2qm74 6934 2 is be VBZ cord-015021-pol2qm74 6934 3 a a DT cord-015021-pol2qm74 6934 4 potent potent JJ cord-015021-pol2qm74 6934 5 secretagogue secretagogue NN cord-015021-pol2qm74 6934 6 for for IN cord-015021-pol2qm74 6934 7 pituitary pituitary JJ cord-015021-pol2qm74 6934 8 growth growth NN cord-015021-pol2qm74 6934 9 hormone hormone NN cord-015021-pol2qm74 6934 10 and and CC cord-015021-pol2qm74 6934 11 prolacfin prolacfin NN cord-015021-pol2qm74 6934 12 and and CC cord-015021-pol2qm74 6934 13 for for IN cord-015021-pol2qm74 6934 14 pancreatic pancreatic JJ cord-015021-pol2qm74 6934 15 insulin insulin NN cord-015021-pol2qm74 6934 16 and and CC cord-015021-pol2qm74 6934 17 glueagon glueagon NNP cord-015021-pol2qm74 6934 18 ; ; : cord-015021-pol2qm74 6934 19 it -PRON- PRP cord-015021-pol2qm74 6934 20 modulates modulate VBZ cord-015021-pol2qm74 6934 21 host host NN cord-015021-pol2qm74 6934 22 protein protein NN cord-015021-pol2qm74 6934 23 metabolism metabolism NN cord-015021-pol2qm74 6934 24 by by IN cord-015021-pol2qm74 6934 25 increasing increase VBG cord-015021-pol2qm74 6934 26 nkmgen nkmgen NNP cord-015021-pol2qm74 6934 27 retention retention NN cord-015021-pol2qm74 6934 28 and and CC cord-015021-pol2qm74 6934 29 enhancing enhance VBG cord-015021-pol2qm74 6934 30 wound wound NN cord-015021-pol2qm74 6934 31 collagen collagen NN cord-015021-pol2qm74 6934 32 synthesis synthesis NN cord-015021-pol2qm74 6934 33 . . . cord-015021-pol2qm74 6935 1 It -PRON- PRP cord-015021-pol2qm74 6935 2 also also RB cord-015021-pol2qm74 6935 3 is be VBZ cord-015021-pol2qm74 6935 4 a a DT cord-015021-pol2qm74 6935 5 potent potent JJ cord-015021-pol2qm74 6935 6 T t NN cord-015021-pol2qm74 6935 7 call call NN cord-015021-pol2qm74 6935 8 function function NN cord-015021-pol2qm74 6935 9 regulator regulator NN cord-015021-pol2qm74 6935 10 . . . cord-015021-pol2qm74 6936 1 AIt AIt NNS cord-015021-pol2qm74 6936 2 of of IN cord-015021-pol2qm74 6936 3 these these DT cord-015021-pol2qm74 6936 4 effects effect NNS cord-015021-pol2qm74 6936 5 coupled couple VBN cord-015021-pol2qm74 6936 6 with with IN cord-015021-pol2qm74 6936 7 its -PRON- PRP$ cord-015021-pol2qm74 6936 8 relative relative JJ cord-015021-pol2qm74 6936 9 lack lack NN cord-015021-pol2qm74 6936 10 of of IN cord-015021-pol2qm74 6936 11 toxicity toxicity NN cord-015021-pol2qm74 6936 12 and and CC cord-015021-pol2qm74 6936 13 safety safety NN cord-015021-pol2qm74 6936 14 make make VBP cord-015021-pol2qm74 6936 15 it -PRON- PRP cord-015021-pol2qm74 6936 16 an an DT cord-015021-pol2qm74 6936 17 a a NN cord-015021-pol2qm74 6936 18 ~ ~ NFP cord-015021-pol2qm74 6936 19 antive antive NNP cord-015021-pol2qm74 6936 20 nulritionai nulritionai NNPS cord-015021-pol2qm74 6936 21 pharmacologic pharmacologic NNP cord-015021-pol2qm74 6936 22 agem agem NNPS cord-015021-pol2qm74 6936 23 ( ( -LRB- cord-015021-pol2qm74 6936 24 t t NN cord-015021-pol2qm74 6936 25 ) ) -RRB- cord-015021-pol2qm74 6936 26 . . . cord-015021-pol2qm74 6937 1 Rodents rodent NNS cord-015021-pol2qm74 6937 2 fed feed VBN cord-015021-pol2qm74 6938 1 supplemeutal supplemeutal NNP cord-015021-pol2qm74 6938 2 arginine arginine NNP cord-015021-pol2qm74 6938 3 exhibit exhibit NN cord-015021-pol2qm74 6938 4 increased increase VBD cord-015021-pol2qm74 6938 5 thymSc thymsc CD cord-015021-pol2qm74 6938 6 weight weight NN cord-015021-pol2qm74 6938 7 which which WDT cord-015021-pol2qm74 6938 8 is be VBZ cord-015021-pol2qm74 6938 9 due due JJ cord-015021-pol2qm74 6938 10 to to IN cord-015021-pol2qm74 6938 11 increased increase VBN cord-015021-pol2qm74 6938 12 numbers number NNS cord-015021-pol2qm74 6938 13 of of IN cord-015021-pol2qm74 6938 14 thymic thymic JJ cord-015021-pol2qm74 6938 15 lymphocytes lymphocyte NNS cord-015021-pol2qm74 6938 16 present present JJ cord-015021-pol2qm74 6938 17 in in IN cord-015021-pol2qm74 6938 18 the the DT cord-015021-pol2qm74 6938 19 gland gland NN cord-015021-pol2qm74 6938 20 . . . cord-015021-pol2qm74 6939 1 Thymic Thymic NNP cord-015021-pol2qm74 6939 2 lymphocytes lymphocyte NNS cord-015021-pol2qm74 6939 3 from from IN cord-015021-pol2qm74 6939 4 animals animal NNS cord-015021-pol2qm74 6939 5 fed feed VBD cord-015021-pol2qm74 6939 6 supplemental supplemental NNP cord-015021-pol2qm74 6939 7 ar ar NNP cord-015021-pol2qm74 6939 8 ~ ~ NFP cord-015021-pol2qm74 6939 9 e e TO cord-015021-pol2qm74 6939 10 demonstrate demonstrate VB cord-015021-pol2qm74 6939 11 increased increase VBN cord-015021-pol2qm74 6939 12 blastogenesis blastogenesis NN cord-015021-pol2qm74 6939 13 in in IN cord-015021-pol2qm74 6939 14 response response NN cord-015021-pol2qm74 6939 15 to to IN cord-015021-pol2qm74 6939 16 Coma Coma NNP cord-015021-pol2qm74 6939 17 . . . cord-015021-pol2qm74 6940 1 and and CC cord-015021-pol2qm74 6940 2 PHA PHA NNP cord-015021-pol2qm74 6940 3 ( ( -LRB- cord-015021-pol2qm74 6940 4 2 2 CD cord-015021-pol2qm74 6940 5 ) ) -RRB- cord-015021-pol2qm74 6940 6 . . . cord-015021-pol2qm74 6941 1 Peripheral peripheral JJ cord-015021-pol2qm74 6941 2 blood blood NN cord-015021-pol2qm74 6941 3 lymphocytes lymphocyte NNS cord-015021-pol2qm74 6941 4 from from IN cord-015021-pol2qm74 6941 5 humans human NNS cord-015021-pol2qm74 6941 6 given give VBN cord-015021-pol2qm74 6941 7 supplemental supplemental JJ cord-015021-pol2qm74 6941 8 arginine arginine NN cord-015021-pol2qm74 6941 9 also also RB cord-015021-pol2qm74 6941 10 have have VBP cord-015021-pol2qm74 6941 11 heightened heighten VBN cord-015021-pol2qm74 6941 12 mitogunic mitogunic NNP cord-015021-pol2qm74 6941 13 responses response NNS cord-015021-pol2qm74 6941 14 to to IN cord-015021-pol2qm74 6941 15 mitogen mitogen NNP cord-015021-pol2qm74 6941 16 or or CC cord-015021-pol2qm74 6941 17 antigens antigen NNS cord-015021-pol2qm74 6941 18 ( ( -LRB- cord-015021-pol2qm74 6941 19 3 3 CD cord-015021-pol2qm74 6941 20 ) ) -RRB- cord-015021-pol2qm74 6941 21 . . . cord-015021-pol2qm74 6942 1 In in IN cord-015021-pol2qm74 6942 2 postsurgery postsurgery NNP cord-015021-pol2qm74 6942 3 padents padent NNS cord-015021-pol2qm74 6942 4 supplemental supplemental JJ cord-015021-pol2qm74 6942 5 arginine arginine NN cord-015021-pol2qm74 6942 6 abrogates abrogate VBZ cord-015021-pol2qm74 6942 7 or or CC cord-015021-pol2qm74 6942 8 diminishes diminish VBZ cord-015021-pol2qm74 6942 9 the the DT cord-015021-pol2qm74 6942 10 deleterious deleterious JJ cord-015021-pol2qm74 6942 11 effects effect NNS cord-015021-pol2qm74 6942 12 of of IN cord-015021-pol2qm74 6942 13 trauma trauma NN cord-015021-pol2qm74 6942 14 on on IN cord-015021-pol2qm74 6942 15 lymphocyte lymphocyte NN cord-015021-pol2qm74 6942 16 responsiveness responsiveness NN cord-015021-pol2qm74 6942 17 and and CC cord-015021-pol2qm74 6942 18 restores restore VBZ cord-015021-pol2qm74 6942 19 peripheral peripheral JJ cord-015021-pol2qm74 6942 20 blood blood NN cord-015021-pol2qm74 6942 21 lymphocyte lymphocyte NN cord-015021-pol2qm74 6942 22 responses response NNS cord-015021-pol2qm74 6942 23 much much RB cord-015021-pol2qm74 6942 24 faster fast RBR cord-015021-pol2qm74 6942 25 than than IN cord-015021-pol2qm74 6942 26 observed observe VBN cord-015021-pol2qm74 6942 27 in in IN cord-015021-pol2qm74 6942 28 controls control NNS cord-015021-pol2qm74 6942 29 . . . cord-015021-pol2qm74 6943 1 Overall overall JJ cord-015021-pol2qm74 6943 2 host host NN cord-015021-pol2qm74 6943 3 immunity immunity NN cord-015021-pol2qm74 6943 4 is be VBZ cord-015021-pol2qm74 6943 5 also also RB cord-015021-pol2qm74 6943 6 enhanced enhance VBN cord-015021-pol2qm74 6943 7 by by IN cord-015021-pol2qm74 6943 8 arginine arginine NN cord-015021-pol2qm74 6943 9 . . . cord-015021-pol2qm74 6944 1 Allograft Allograft NNP cord-015021-pol2qm74 6944 2 rejection rejection NN cord-015021-pol2qm74 6944 3 is be VBZ cord-015021-pol2qm74 6944 4 enhanced enhance VBN cord-015021-pol2qm74 6944 5 and and CC cord-015021-pol2qm74 6944 6 septic septic JJ cord-015021-pol2qm74 6944 7 animals animal NNS cord-015021-pol2qm74 6944 8 survive survive VBP cord-015021-pol2qm74 6944 9 longer long RBR cord-015021-pol2qm74 6944 10 when when WRB cord-015021-pol2qm74 6944 11 given give VBN cord-015021-pol2qm74 6944 12 supplemental supplemental JJ cord-015021-pol2qm74 6944 13 arginine arginine NN cord-015021-pol2qm74 6944 14 ( ( -LRB- cord-015021-pol2qm74 6944 15 4 4 CD cord-015021-pol2qm74 6944 16 ) ) -RRB- cord-015021-pol2qm74 6944 17 . . . cord-015021-pol2qm74 6945 1 Tumor tumor NN cord-015021-pol2qm74 6945 2 bearing bear VBG cord-015021-pol2qm74 6945 3 urginine urginine NN cord-015021-pol2qm74 6945 4 - - HYPH cord-015021-pol2qm74 6945 5 supplemented supplement VBN cord-015021-pol2qm74 6945 6 animals animal NNS cord-015021-pol2qm74 6945 7 have have VBP cord-015021-pol2qm74 6945 8 decreased decrease VBN cord-015021-pol2qm74 6945 9 tumor tumor NN cord-015021-pol2qm74 6945 10 growth growth NN cord-015021-pol2qm74 6945 11 and and CC cord-015021-pol2qm74 6945 12 enhanced enhanced JJ cord-015021-pol2qm74 6945 13 survival survival NN cord-015021-pol2qm74 6945 14 ( ( -LRB- cord-015021-pol2qm74 6945 15 i i NN cord-015021-pol2qm74 6945 16 ) ) -RRB- cord-015021-pol2qm74 6945 17 . . . cord-015021-pol2qm74 6946 1 Lastly lastly RB cord-015021-pol2qm74 6946 2 , , , cord-015021-pol2qm74 6946 3 asgmine asgmine NNP cord-015021-pol2qm74 6946 4 can can MD cord-015021-pol2qm74 6946 5 induce induce VB cord-015021-pol2qm74 6946 6 T T NNP cord-015021-pol2qm74 6946 7 cell cell NN cord-015021-pol2qm74 6946 8 maturation maturation NN cord-015021-pol2qm74 6946 9 and and CC cord-015021-pol2qm74 6946 10 T t NN cord-015021-pol2qm74 6946 11 cell cell NN cord-015021-pol2qm74 6946 12 mediated mediate VBD cord-015021-pol2qm74 6946 13 responses response NNS cord-015021-pol2qm74 6946 14 in in IN cord-015021-pol2qm74 6946 15 athyrnic athyrnic NNP cord-015021-pol2qm74 6946 16 nude nude JJ cord-015021-pol2qm74 6946 17 mice mouse NNS cord-015021-pol2qm74 6946 18 . . . cord-015021-pol2qm74 6947 1 Arginine arginine NN cord-015021-pol2qm74 6947 2 also also RB cord-015021-pol2qm74 6947 3 has have VBZ cord-015021-pol2qm74 6947 4 remarkable remarkable JJ cord-015021-pol2qm74 6947 5 effects effect NNS cord-015021-pol2qm74 6947 6 on on IN cord-015021-pol2qm74 6947 7 host host NN cord-015021-pol2qm74 6947 8 nitrogen nitrogen NN cord-015021-pol2qm74 6947 9 metabolism metabolism NN cord-015021-pol2qm74 6947 10 post post JJ cord-015021-pol2qm74 6947 11 - - NN cord-015021-pol2qm74 6947 12 injury injury NN cord-015021-pol2qm74 6947 13 . . . cord-015021-pol2qm74 6948 1 In in IN cord-015021-pol2qm74 6948 2 increases increase NNS cord-015021-pol2qm74 6948 3 nitrogen nitrogen NN cord-015021-pol2qm74 6948 4 retention retention NN cord-015021-pol2qm74 6948 5 in in IN cord-015021-pol2qm74 6948 6 healthy healthy JJ cord-015021-pol2qm74 6948 7 human human JJ cord-015021-pol2qm74 6948 8 volunteers volunteer NNS cord-015021-pol2qm74 6948 9 and and CC cord-015021-pol2qm74 6948 10 in in IN cord-015021-pol2qm74 6948 11 surgical surgical JJ cord-015021-pol2qm74 6948 12 patients patient NNS cord-015021-pol2qm74 6948 13 . . . cord-015021-pol2qm74 6949 1 This this DT cord-015021-pol2qm74 6949 2 beneficial beneficial JJ cord-015021-pol2qm74 6949 3 effect effect NN cord-015021-pol2qm74 6949 4 on on IN cord-015021-pol2qm74 6949 5 overall overall JJ cord-015021-pol2qm74 6949 6 nitrogen nitrogen NN cord-015021-pol2qm74 6949 7 metabolism metabolism NN cord-015021-pol2qm74 6949 8 is be VBZ cord-015021-pol2qm74 6949 9 accompanied accompany VBN cord-015021-pol2qm74 6949 10 by by IN cord-015021-pol2qm74 6949 11 a a DT cord-015021-pol2qm74 6949 12 unique unique JJ cord-015021-pol2qm74 6949 13 effect effect NN cord-015021-pol2qm74 6949 14 on on IN cord-015021-pol2qm74 6949 15 the the DT cord-015021-pol2qm74 6949 16 healing healing NN cord-015021-pol2qm74 6949 17 wound wound NN cord-015021-pol2qm74 6949 18 . . . cord-015021-pol2qm74 6950 1 Supp]emental Supp]emental NNP cord-015021-pol2qm74 6951 1 arginine arginine NN cord-015021-pol2qm74 6951 2 increases increase NNS cord-015021-pol2qm74 6951 3 wound wound VBP cord-015021-pol2qm74 6951 4 collagen collagen NN cord-015021-pol2qm74 6951 5 synthesis synthesis NN cord-015021-pol2qm74 6951 6 which which WDT cord-015021-pol2qm74 6951 7 also also RB cord-015021-pol2qm74 6951 8 translates translate VBZ cord-015021-pol2qm74 6951 9 into into IN cord-015021-pol2qm74 6951 10 increased increased JJ cord-015021-pol2qm74 6951 11 wound wound NN cord-015021-pol2qm74 6951 12 breaking break VBG cord-015021-pol2qm74 6951 13 strength strength NN cord-015021-pol2qm74 6951 14 ( ( -LRB- cord-015021-pol2qm74 6951 15 5 5 CD cord-015021-pol2qm74 6951 16 ) ) -RRB- cord-015021-pol2qm74 6951 17 . . . cord-015021-pol2qm74 6952 1 Arginine arginine NN cord-015021-pol2qm74 6952 2 has have VBZ cord-015021-pol2qm74 6952 3 no no DT cord-015021-pol2qm74 6952 4 effect effect NN cord-015021-pol2qm74 6952 5 ou ou NNP cord-015021-pol2qm74 6952 6 epithelialization epithelialization NN cord-015021-pol2qm74 6952 7 . . . cord-015021-pol2qm74 6953 1 Douglas Douglas NNP cord-015021-pol2qm74 6953 2 W. W. NNP cord-015021-pol2qm74 6953 3 Wilmom Wilmom NNP cord-015021-pol2qm74 6953 4 , , , cord-015021-pol2qm74 6953 5 M.D. M.D. NNP cord-015021-pol2qm74 6953 6 Boston Boston NNP cord-015021-pol2qm74 6953 7 , , , cord-015021-pol2qm74 6953 8 MA MA NNP cord-015021-pol2qm74 6953 9 Gintamine Gintamine NNP cord-015021-pol2qm74 6953 10 is be VBZ cord-015021-pol2qm74 6953 11 the the DT cord-015021-pol2qm74 6953 12 most most RBS cord-015021-pol2qm74 6953 13 abundant abundant JJ cord-015021-pol2qm74 6953 14 amino amino NN cord-015021-pol2qm74 6953 15 acid acid NN cord-015021-pol2qm74 6953 16 in in IN cord-015021-pol2qm74 6953 17 the the DT cord-015021-pol2qm74 6953 18 body body NN cord-015021-pol2qm74 6953 19 , , , cord-015021-pol2qm74 6953 20 but but CC cord-015021-pol2qm74 6953 21 it -PRON- PRP cord-015021-pol2qm74 6953 22 has have VBZ cord-015021-pol2qm74 6953 23 long long RB cord-015021-pol2qm74 6953 24 been be VBN cord-015021-pol2qm74 6953 25 considered consider VBN cord-015021-pol2qm74 6953 26 a a DT cord-015021-pol2qm74 6953 27 nonessential nonessential JJ cord-015021-pol2qm74 6953 28 amino amino NN cord-015021-pol2qm74 6953 29 aeid aeid NN cord-015021-pol2qm74 6953 30 because because IN cord-015021-pol2qm74 6953 31 it -PRON- PRP cord-015021-pol2qm74 6953 32 is be VBZ cord-015021-pol2qm74 6953 33 synthesized synthesize VBN cord-015021-pol2qm74 6953 34 in in IN cord-015021-pol2qm74 6953 35 many many JJ cord-015021-pol2qm74 6953 36 tissues tissue NNS cord-015021-pol2qm74 6953 37 . . . cord-015021-pol2qm74 6954 1 FoHov FoHov NNP cord-015021-pol2qm74 6954 2 ~ ~ NFP cord-015021-pol2qm74 6954 3 g g NNP cord-015021-pol2qm74 6954 4 st,~'vation~ st,~'vation~ , cord-015021-pol2qm74 6954 5 injury injury NN cord-015021-pol2qm74 6954 6 or or CC cord-015021-pol2qm74 6954 7 infection infection NN cord-015021-pol2qm74 6954 8 , , , cord-015021-pol2qm74 6954 9 skeletal skeletal JJ cord-015021-pol2qm74 6954 10 muscle muscle NN cord-015021-pol2qm74 6954 11 pmteln pmteln NNP cord-015021-pol2qm74 6954 12 inoresses inoresses NNP cord-015021-pol2qm74 6954 13 its -PRON- PRP$ cord-015021-pol2qm74 6954 14 net net JJ cord-015021-pol2qm74 6954 15 tale tale NN cord-015021-pol2qm74 6954 16 of of IN cord-015021-pol2qm74 6954 17 degradation degradation NN cord-015021-pol2qm74 6954 18 and and CC cord-015021-pol2qm74 6954 19 releases release VBZ cord-015021-pol2qm74 6954 20 amino amino NN cord-015021-pol2qm74 6954 21 acids acid NNS cord-015021-pol2qm74 6954 22 into into IN cord-015021-pol2qm74 6954 23 the the DT cord-015021-pol2qm74 6954 24 blunds blund NNS cord-015021-pol2qm74 6954 25 ~ ~ NFP cord-015021-pol2qm74 6954 26 mm mm XX cord-015021-pol2qm74 6954 27 at at IN cord-015021-pol2qm74 6954 28 an an DT cord-015021-pol2qm74 6954 29 aocelerared aocelerared JJ cord-015021-pol2qm74 6954 30 rate rate NN cord-015021-pol2qm74 6954 31 . . . cord-015021-pol2qm74 6955 1 App App VBZ cord-015021-pol2qm74 6955 2 ~ ~ NFP cord-015021-pol2qm74 6955 3 o)~mately o)~mately RB cord-015021-pol2qm74 6955 4 one one CD cord-015021-pol2qm74 6955 5 - - HYPH cord-015021-pol2qm74 6955 6 third third NN cord-015021-pol2qm74 6955 7 of of IN cord-015021-pol2qm74 6955 8 the the DT cord-015021-pol2qm74 6955 9 amino amino NN cord-015021-pol2qm74 6955 10 nitmgea nitmgea NNP cord-015021-pol2qm74 6955 11 is be VBZ cord-015021-pol2qm74 6955 12 ghitamine ghitamine NNP cord-015021-pol2qm74 6955 13 , , , cord-015021-pol2qm74 6955 14 which which WDT cord-015021-pol2qm74 6955 15 is be VBZ cord-015021-pol2qm74 6955 16 metabolized metabolize VBN cord-015021-pol2qm74 6955 17 by by IN cord-015021-pol2qm74 6955 18 the the DT cord-015021-pol2qm74 6955 19 kidney kidney NN cord-015021-pol2qm74 6955 20 where where WRB cord-015021-pol2qm74 6955 21 it -PRON- PRP cord-015021-pol2qm74 6955 22 parth:~pates parth:~pate VBZ cord-015021-pol2qm74 6955 23 in in IN cord-015021-pol2qm74 6955 24 acid acid NN cord-015021-pol2qm74 6955 25 - - HYPH cord-015021-pol2qm74 6955 26 base base NN cord-015021-pol2qm74 6955 27 homeostasis homeostasis NN cord-015021-pol2qm74 6955 28 , , , cord-015021-pol2qm74 6955 29 is be VBZ cord-015021-pol2qm74 6955 30 the the DT cord-015021-pol2qm74 6955 31 primly primly NN cord-015021-pol2qm74 6955 32 ~ ~ NFP cord-015021-pol2qm74 6955 33 for for IN cord-015021-pol2qm74 6955 34 lymphocytes lymphocyte NNS cord-015021-pol2qm74 6955 35 , , , cord-015021-pol2qm74 6955 36 mac mac NNP cord-015021-pol2qm74 6955 37 ~ ~ NNP cord-015021-pol2qm74 6955 38 optmgcs optmgcs NNP cord-015021-pol2qm74 6955 39 and and CC cord-015021-pol2qm74 6955 40 untexocyms untexocyms NNP cord-015021-pol2qm74 6955 41 , , , cord-015021-pol2qm74 6955 42 and and CC cord-015021-pol2qm74 6955 43 contm'butcs contm'butcs NNP cord-015021-pol2qm74 6955 44 to to IN cord-015021-pol2qm74 6955 45 the the DT cord-015021-pol2qm74 6955 46 synthesis synthesis NN cord-015021-pol2qm74 6955 47 of of IN cord-015021-pol2qm74 6955 48 giumth~ giumth~ NNP cord-015021-pol2qm74 6956 1 une une NNP cord-015021-pol2qm74 6956 2 . . . cord-015021-pol2qm74 6957 1 Olmamine Olmamine NNP cord-015021-pol2qm74 6957 2 degrades degrade VBZ cord-015021-pol2qm74 6957 3 slowly slowly RB cord-015021-pol2qm74 6957 4 while while IN cord-015021-pol2qm74 6957 5 in in IN cord-015021-pol2qm74 6957 6 ~olu ~olu NNP cord-015021-pol2qm74 6958 1 ~ou ~ou NNP cord-015021-pol2qm74 6958 2 , , , cord-015021-pol2qm74 6958 3 especially especially RB cord-015021-pol2qm74 6958 4 at at IN cord-015021-pol2qm74 6958 5 usual usual JJ cord-015021-pol2qm74 6958 6 room room NN cord-015021-pol2qm74 6958 7 teml teml NN cord-015021-pol2qm74 6958 8 ~ ~ NFP cord-015021-pol2qm74 6958 9 mtums mtum NNS cord-015021-pol2qm74 6958 10 . . . cord-015021-pol2qm74 6959 1 Because because IN cord-015021-pol2qm74 6959 2 giulamine giulamine NNP cord-015021-pol2qm74 6959 3 was be VBD cord-015021-pol2qm74 6959 4 considered consider VBN cord-015021-pol2qm74 6959 5 nonessential nonessential JJ cord-015021-pol2qm74 6959 6 , , , cord-015021-pol2qm74 6959 7 it -PRON- PRP cord-015021-pol2qm74 6959 8 has have VBZ cord-015021-pol2qm74 6959 9 beer beer NN cord-015021-pol2qm74 6959 10 absent absent JJ cord-015021-pol2qm74 6959 11 R'om r'om JJ cord-015021-pol2qm74 6959 12 nil nil NN cord-015021-pol2qm74 6959 13 intravenous intravenous JJ cord-015021-pol2qm74 6959 14 and and CC cord-015021-pol2qm74 6959 15 most most JJS cord-015021-pol2qm74 6959 16 Gluts.mine gluts.mine PRP cord-015021-pol2qm74 6959 17 should should MD cord-015021-pol2qm74 6959 18 be be VB cord-015021-pol2qm74 6959 19 considered consider VBN cord-015021-pol2qm74 6959 20 a a DT cord-015021-pol2qm74 6959 21 cendittona]ly cendittona]ly NN cord-015021-pol2qm74 6959 22 essential essential JJ cord-015021-pol2qm74 6959 23 nutrient nutrient NN cord-015021-pol2qm74 6959 24 for for IN cord-015021-pol2qm74 6959 25 individuals individual NNS cord-015021-pol2qm74 6959 26 with with IN cord-015021-pol2qm74 6959 27 serious serious JJ cord-015021-pol2qm74 6959 28 ilinesses ilinesse NNS cord-015021-pol2qm74 6959 29 , , , cord-015021-pol2qm74 6959 30 uspccially uspccially RB cord-015021-pol2qm74 6959 31 those those DT cord-015021-pol2qm74 6959 32 confoanded confoande VBN cord-015021-pol2qm74 6959 33 by by IN cord-015021-pol2qm74 6959 34 infcctinn infcctinn NNP cord-015021-pol2qm74 6959 35 and and CC cord-015021-pol2qm74 6959 36 inflammation inflammation NN cord-015021-pol2qm74 6959 37 . . . cord-015021-pol2qm74 6960 1 Over over IN cord-015021-pol2qm74 6960 2 the the DT cord-015021-pol2qm74 6960 3 uc~:t uc~:t CD cord-015021-pol2qm74 6960 4 5 5 CD cord-015021-pol2qm74 6960 5 - - SYM cord-015021-pol2qm74 6960 6 7 7 CD cord-015021-pol2qm74 6960 7 years year NNS cord-015021-pol2qm74 6960 8 , , , cord-015021-pol2qm74 6960 9 glutamine glutamine NN cord-015021-pol2qm74 6960 10 will will MD cord-015021-pol2qm74 6960 11 be be VB cord-015021-pol2qm74 6960 12 incorgorated incorgorate VBN cord-015021-pol2qm74 6960 13 into into IN cord-015021-pol2qm74 6960 14 most most JJS cord-015021-pol2qm74 6960 15 feeding feeding NN cord-015021-pol2qm74 6960 16 formulas formula NNS cord-015021-pol2qm74 6960 17 designed design VBN cord-015021-pol2qm74 6960 18 for for IN cord-015021-pol2qm74 6960 19 patients patient NNS cord-015021-pol2qm74 6960 20 with with IN cord-015021-pol2qm74 6960 21 critical critical JJ cord-015021-pol2qm74 6960 22 illness illness NN cord-015021-pol2qm74 6960 23 . . . cord-015021-pol2qm74 6961 1 526 526 CD cord-015021-pol2qm74 6961 2 O]~GA-3 o]~ga-3 NN cord-015021-pol2qm74 6961 3 PUFA PUFA NNS cord-015021-pol2qm74 6962 1 There there EX cord-015021-pol2qm74 6962 2 continues continue VBZ cord-015021-pol2qm74 6962 3 to to IN cord-015021-pol2qm74 6962 4 much much JJ cord-015021-pol2qm74 6962 5 interest interest NN cord-015021-pol2qm74 6962 6 in in IN cord-015021-pol2qm74 6962 7 the the DT cord-015021-pol2qm74 6962 8 application application NN cord-015021-pol2qm74 6962 9 of of IN cord-015021-pol2qm74 6962 10 the the DT cord-015021-pol2qm74 6962 11 0mega-3 0mega-3 CD cord-015021-pol2qm74 6962 12 PUFA PUFA NNP cord-015021-pol2qm74 6962 13 in in IN cord-015021-pol2qm74 6962 14 clinical clinical JJ cord-015021-pol2qm74 6962 15 nutrition nutrition NN cord-015021-pol2qm74 6962 16 . . . cord-015021-pol2qm74 6963 1 The the DT cord-015021-pol2qm74 6963 2 basic basic JJ cord-015021-pol2qm74 6963 3 principle principle NN cord-015021-pol2qm74 6963 4 has have VBZ cord-015021-pol2qm74 6963 5 been be VBN cord-015021-pol2qm74 6963 6 that that IN cord-015021-pol2qm74 6963 7 the the DT cord-015021-pol2qm74 6963 8 0mega-3 0mega-3 CD cord-015021-pol2qm74 6963 9 PUFA PUFA NNP cord-015021-pol2qm74 6963 10 will will MD cord-015021-pol2qm74 6963 11 displace displace VB cord-015021-pol2qm74 6963 12 arachidunic arachidunic JJ cord-015021-pol2qm74 6963 13 acid acid NN cord-015021-pol2qm74 6963 14 and and CC cord-015021-pol2qm74 6963 15 result result VB cord-015021-pol2qm74 6963 16 in in IN cord-015021-pol2qm74 6963 17 a a DT cord-015021-pol2qm74 6963 18 decrease decrease NN cord-015021-pol2qm74 6963 19 in in IN cord-015021-pol2qm74 6963 20 eic0san0id eic0san0id VBG cord-015021-pol2qm74 6963 21 production production NN cord-015021-pol2qm74 6963 22 . . . cord-015021-pol2qm74 6964 1 In in IN cord-015021-pol2qm74 6964 2 addition addition NN cord-015021-pol2qm74 6964 3 these these DT cord-015021-pol2qm74 6964 4 changes change NNS cord-015021-pol2qm74 6964 5 in in IN cord-015021-pol2qm74 6964 6 PUFA PUFA NNP cord-015021-pol2qm74 6964 7 will will MD cord-015021-pol2qm74 6964 8 after after IN cord-015021-pol2qm74 6964 9 the the DT cord-015021-pol2qm74 6964 10 physical physical JJ cord-015021-pol2qm74 6964 11 characteristics characteristic NNS cord-015021-pol2qm74 6964 12 of of IN cord-015021-pol2qm74 6964 13 the the DT cord-015021-pol2qm74 6964 14 membrane membrane NN cord-015021-pol2qm74 6964 15 including include VBG cord-015021-pol2qm74 6964 16 flujdity flujdity NN cord-015021-pol2qm74 6964 17 , , , cord-015021-pol2qm74 6964 18 receptor receptor NN cord-015021-pol2qm74 6964 19 function function NN cord-015021-pol2qm74 6964 20 and and CC cord-015021-pol2qm74 6964 21 transmembrane transmembrane NN cord-015021-pol2qm74 6964 22 signals signal NNS cord-015021-pol2qm74 6964 23 . . . cord-015021-pol2qm74 6965 1 Animal animal NN cord-015021-pol2qm74 6965 2 studies study NNS cord-015021-pol2qm74 6965 3 have have VBP cord-015021-pol2qm74 6965 4 shown show VBN cord-015021-pol2qm74 6965 5 that that IN cord-015021-pol2qm74 6965 6 there there EX cord-015021-pol2qm74 6965 7 is be VBZ cord-015021-pol2qm74 6965 8 omega-3 omega-3 NN cord-015021-pol2qm74 6965 9 incorporation incorporation NN cord-015021-pol2qm74 6965 10 with with IN cord-015021-pol2qm74 6965 11 continuou~ continuou~ NN cord-015021-pol2qm74 6965 12 enteral enteral NN cord-015021-pol2qm74 6965 13 feeding feed VBG cord-015021-pol2qm74 6965 14 both both CC cord-015021-pol2qm74 6965 15 in in IN cord-015021-pol2qm74 6965 16 control control NN cord-015021-pol2qm74 6965 17 and and CC cord-015021-pol2qm74 6965 18 endotoxic endotoxic JJ cord-015021-pol2qm74 6965 19 animals animal NNS cord-015021-pol2qm74 6965 20 within within IN cord-015021-pol2qm74 6965 21 3 3 CD cord-015021-pol2qm74 6965 22 days day NNS cord-015021-pol2qm74 6965 23 . . . cord-015021-pol2qm74 6966 1 This this DT cord-015021-pol2qm74 6966 2 includes include VBZ cord-015021-pol2qm74 6966 3 the the DT cord-015021-pol2qm74 6966 4 liver liver NN cord-015021-pol2qm74 6966 5 , , , cord-015021-pol2qm74 6966 6 spleen spleen NNS cord-015021-pol2qm74 6966 7 , , , cord-015021-pol2qm74 6966 8 circulating circulating NN cord-015021-pol2qm74 6966 9 and and CC cord-015021-pol2qm74 6966 10 alveolar alveolar JJ cord-015021-pol2qm74 6966 11 marc0phages marc0phage NNS cord-015021-pol2qm74 6966 12 and and CC cord-015021-pol2qm74 6966 13 the the DT cord-015021-pol2qm74 6966 14 lung lung NN cord-015021-pol2qm74 6966 15 . . . cord-015021-pol2qm74 6967 1 This this DT cord-015021-pol2qm74 6967 2 incorporation incorporation NN cord-015021-pol2qm74 6967 3 resuls resuls NN cord-015021-pol2qm74 6967 4 in in IN cord-015021-pol2qm74 6967 5 significant significant JJ cord-015021-pol2qm74 6967 6 changes change NNS cord-015021-pol2qm74 6967 7 in in IN cord-015021-pol2qm74 6967 8 the the DT cord-015021-pol2qm74 6967 9 eicosan0id eicosan0id NNP cord-015021-pol2qm74 6967 10 production production NN cord-015021-pol2qm74 6967 11 including include VBG cord-015021-pol2qm74 6967 12 PGF PGF NNP cord-015021-pol2qm74 6967 13 2 2 CD cord-015021-pol2qm74 6967 14 and and CC cord-015021-pol2qm74 6967 15 ket0-PGFlalpha ket0-pgflalpha NN cord-015021-pol2qm74 6967 16 . . . cord-015021-pol2qm74 6968 1 There there EX cord-015021-pol2qm74 6968 2 is be VBZ cord-015021-pol2qm74 6968 3 improvement improvement NN cord-015021-pol2qm74 6968 4 in in IN cord-015021-pol2qm74 6968 5 the the DT cord-015021-pol2qm74 6968 6 cardio cardio JJ cord-015021-pol2qm74 6968 7 - - HYPH cord-015021-pol2qm74 6968 8 vascular vascular JJ cord-015021-pol2qm74 6968 9 reep0nse reep0nse NN cord-015021-pol2qm74 6968 10 of of IN cord-015021-pol2qm74 6968 11 these these DT cord-015021-pol2qm74 6968 12 animals animal NNS cord-015021-pol2qm74 6968 13 with with IN cord-015021-pol2qm74 6968 14 ~ecreamed ~ecreamed CD cord-015021-pol2qm74 6968 15 lactic lactic JJ cord-015021-pol2qm74 6968 16 acidosis acidosis NN cord-015021-pol2qm74 6968 17 and and CC cord-015021-pol2qm74 6968 18 improved improved JJ cord-015021-pol2qm74 6968 19 cardiac cardiac JJ cord-015021-pol2qm74 6968 20 contractility contractility NN cord-015021-pol2qm74 6968 21 . . . cord-015021-pol2qm74 6969 1 As as RB cord-015021-pol2qm74 6969 2 well well RB cord-015021-pol2qm74 6969 3 there there EX cord-015021-pol2qm74 6969 4 is be VBZ cord-015021-pol2qm74 6969 5 improved improve VBN cord-015021-pol2qm74 6969 6 immune immune JJ cord-015021-pol2qm74 6969 7 function function NN cord-015021-pol2qm74 6969 8 with with IN cord-015021-pol2qm74 6969 9 improved improve VBN cord-015021-pol2qm74 6969 10 T T NNP cord-015021-pol2qm74 6969 11 cell cell NN cord-015021-pol2qm74 6969 12 response response NN cord-015021-pol2qm74 6969 13 to to IN cord-015021-pol2qm74 6969 14 mit0gens mit0gens NNP cord-015021-pol2qm74 6969 15 . . . cord-015021-pol2qm74 6970 1 The the DT cord-015021-pol2qm74 6970 2 ~ ~ NFP cord-015021-pol2qm74 6970 3 of of IN cord-015021-pol2qm74 6970 4 a a DT cord-015021-pol2qm74 6970 5 mumber mumber NN cord-015021-pol2qm74 6970 6 of of IN cord-015021-pol2qm74 6970 7 pharmacological pharmacological JJ cord-015021-pol2qm74 6970 8 agents agent NNS cord-015021-pol2qm74 6970 9 blocking block VBG cord-015021-pol2qm74 6970 10 cicosanoid cicosanoid NN cord-015021-pol2qm74 6970 11 production production NN cord-015021-pol2qm74 6970 12 can can MD cord-015021-pol2qm74 6970 13 enhance enhance VB cord-015021-pol2qm74 6970 14 the the DT cord-015021-pol2qm74 6970 15 cell cell NN cord-015021-pol2qm74 6970 16 effects effect NNS cord-015021-pol2qm74 6970 17 of of IN cord-015021-pol2qm74 6970 18 0mega-3 0mega-3 CD cord-015021-pol2qm74 6970 19 PUFA PUFA NNP cord-015021-pol2qm74 6970 20 . . . cord-015021-pol2qm74 6971 1 Clinical clinical JJ cord-015021-pol2qm74 6971 2 studies study NNS cord-015021-pol2qm74 6971 3 using use VBG cord-015021-pol2qm74 6971 4 short short JJ cord-015021-pol2qm74 6971 5 term term NN cord-015021-pol2qm74 6971 6 entsral entsral JJ cord-015021-pol2qm74 6971 7 nutrition nutrition NN cord-015021-pol2qm74 6971 8 with with IN cord-015021-pol2qm74 6971 9 0mega-3 0mega-3 CD cord-015021-pol2qm74 6972 1 either either CC cord-015021-pol2qm74 6972 2 alone alone RB cord-015021-pol2qm74 6972 3 or or CC cord-015021-pol2qm74 6972 4 with with IN cord-015021-pol2qm74 6972 5 other other JJ cord-015021-pol2qm74 6972 6 enteral enteral JJ cord-015021-pol2qm74 6972 7 supplements supplement NNS cord-015021-pol2qm74 6972 8 in in IN cord-015021-pol2qm74 6972 9 a a DT cord-015021-pol2qm74 6972 10 number number NN cord-015021-pol2qm74 6972 11 of of IN cord-015021-pol2qm74 6972 12 clinical clinical JJ cord-015021-pol2qm74 6972 13 settings setting NNS cord-015021-pol2qm74 6972 14 have have VBP cord-015021-pol2qm74 6972 15 shown show VBN cord-015021-pol2qm74 6972 16 significant significant JJ cord-015021-pol2qm74 6972 17 0mesa-3 0mesa-3 CD cord-015021-pol2qm74 6972 18 incorporation incorporation NN cord-015021-pol2qm74 6972 19 and and CC cord-015021-pol2qm74 6972 20 decreased decrease VBD cord-015021-pol2qm74 6972 21 eicosan0id eicosan0id NNP cord-015021-pol2qm74 6972 22 production production NN cord-015021-pol2qm74 6972 23 . . . cord-015021-pol2qm74 6973 1 These these DT cord-015021-pol2qm74 6973 2 positive positive JJ cord-015021-pol2qm74 6973 3 results result NNS cord-015021-pol2qm74 6973 4 must must MD cord-015021-pol2qm74 6973 5 be be VB cord-015021-pol2qm74 6973 6 discussed discuss VBN cord-015021-pol2qm74 6973 7 with with IN cord-015021-pol2qm74 6973 8 the the DT cord-015021-pol2qm74 6973 9 additional additional JJ cord-015021-pol2qm74 6973 10 evidence evidence NN cord-015021-pol2qm74 6973 11 that that IN cord-015021-pol2qm74 6973 12 long long JJ cord-015021-pol2qm74 6973 13 term term NN cord-015021-pol2qm74 6973 14 omega-3 omega-3 NN cord-015021-pol2qm74 6973 15 supplementation supplementation NN cord-015021-pol2qm74 6973 16 decrease decrease NN cord-015021-pol2qm74 6973 17 eic0san0id eic0san0id JJ cord-015021-pol2qm74 6973 18 production production NN cord-015021-pol2qm74 6973 19 but but CC cord-015021-pol2qm74 6973 20 als0 als0 NN cord-015021-pol2qm74 6973 21 induce induce VB cord-015021-pol2qm74 6973 22 a a DT cord-015021-pol2qm74 6973 23 state state NN cord-015021-pol2qm74 6973 24 of of IN cord-015021-pol2qm74 6973 25 immune immune JJ cord-015021-pol2qm74 6973 26 suppression suppression NN cord-015021-pol2qm74 6973 27 that that WDT cord-015021-pol2qm74 6973 28 is be VBZ cord-015021-pol2qm74 6973 29 capable capable JJ cord-015021-pol2qm74 6973 30 of of IN cord-015021-pol2qm74 6973 31 increasing increase VBG cord-015021-pol2qm74 6973 32 transplant transplant NN cord-015021-pol2qm74 6973 33 sunvival sunvival NN cord-015021-pol2qm74 6973 34 . . . cord-015021-pol2qm74 6974 1 These these DT cord-015021-pol2qm74 6974 2 10ng 10ng JJ cord-015021-pol2qm74 6974 3 te~ te~ NNP cord-015021-pol2qm74 6974 4 inune inune NNP cord-015021-pol2qm74 6974 5 effects effect NNS cord-015021-pol2qm74 6974 6 may may MD cord-015021-pol2qm74 6974 7 benefit benefit VB cord-015021-pol2qm74 6974 8 clinical clinical JJ cord-015021-pol2qm74 6974 9 conditions condition NNS cord-015021-pol2qm74 6974 10 including include VBG cord-015021-pol2qm74 6974 11 rheumatoid rheumatoid NN cord-015021-pol2qm74 6974 12 arthritis arthritis NN cord-015021-pol2qm74 6974 13 and and CC cord-015021-pol2qm74 6974 14 Cr0hn Cr0hn NNP cord-015021-pol2qm74 6974 15 ' ' POS cord-015021-pol2qm74 6974 16 disease disease NN cord-015021-pol2qm74 6975 1 Early early JJ cord-015021-pol2qm74 6975 2 enteral enteral JJ cord-015021-pol2qm74 6975 3 nutrition nutrition NN cord-015021-pol2qm74 6975 4 instituted institute VBD cord-015021-pol2qm74 6975 5 i i NNP cord-015021-pol2qm74 6975 6 ~ ~ CD cord-015021-pol2qm74 6975 7 mediately mediately NNP cord-015021-pol2qm74 6975 8 afte~ afte~ NNP cord-015021-pol2qm74 6976 1 injury injury NN cord-015021-pol2qm74 6976 2 will will MD cord-015021-pol2qm74 6976 3 decrease decrease VB cord-015021-pol2qm74 6976 4 the the DT cord-015021-pol2qm74 6976 5 entry entry NN cord-015021-pol2qm74 6976 6 of of IN cord-015021-pol2qm74 6976 7 bacteria bacteria NNS cord-015021-pol2qm74 6976 8 into into IN cord-015021-pol2qm74 6976 9 the the DT cord-015021-pol2qm74 6976 10 intestinal intestinal JJ cord-015021-pol2qm74 6976 11 wall wall NN cord-015021-pol2qm74 6976 12 and and CC cord-015021-pol2qm74 6976 13 decrease decrease VB cord-015021-pol2qm74 6976 14 the the DT cord-015021-pol2qm74 6976 15 number number NN cord-015021-pol2qm74 6976 16 of of IN cord-015021-pol2qm74 6976 17 bacteria bacteria NNS cord-015021-pol2qm74 6976 18 that that WDT cord-015021-pol2qm74 6976 19 translocate translocate VBP cord-015021-pol2qm74 6976 20 into into IN cord-015021-pol2qm74 6976 21 the the DT cord-015021-pol2qm74 6976 22 portal portal JJ cord-015021-pol2qm74 6976 23 blood blood NN cord-015021-pol2qm74 6976 24 . . . cord-015021-pol2qm74 6977 1 These these DT cord-015021-pol2qm74 6977 2 reductions reduction NNS cord-015021-pol2qm74 6977 3 are be VBP cord-015021-pol2qm74 6977 4 associated associate VBN cord-015021-pol2qm74 6977 5 with with IN cord-015021-pol2qm74 6977 6 & & CC cord-015021-pol2qm74 6977 7 decreased decreased JJ cord-015021-pol2qm74 6977 8 catabolic catabolic JJ cord-015021-pol2qm74 6977 9 response response NN cord-015021-pol2qm74 6977 10 , , , cord-015021-pol2qm74 6977 11 decreased decrease VBD cord-015021-pol2qm74 6977 12 plasma plasma NN cord-015021-pol2qm74 6977 13 cortisnl cortisnl NNS cord-015021-pol2qm74 6977 14 levels level NNS cord-015021-pol2qm74 6977 15 , , , cord-015021-pol2qm74 6977 16 end end NN cord-015021-pol2qm74 6977 17 decreased decrease VBD cord-015021-pol2qm74 6977 18 VMA VMA NNP cord-015021-pol2qm74 6977 19 excretion excretion NN cord-015021-pol2qm74 6977 20 in in IN cord-015021-pol2qm74 6977 21 the the DT cord-015021-pol2qm74 6977 22 urine urine NN cord-015021-pol2qm74 6977 23 and and CC cord-015021-pol2qm74 6977 24 prevention prevention NN cord-015021-pol2qm74 6977 25 of of IN cord-015021-pol2qm74 6977 26 mueosal mueosal NN cord-015021-pol2qm74 6977 27 atrophy atrophy NN cord-015021-pol2qm74 6977 28 . . . cord-015021-pol2qm74 6978 1 SDecific sdecific JJ cord-015021-pol2qm74 6978 2 nutrients nutrient NNS cord-015021-pol2qm74 6978 3 also also RB cord-015021-pol2qm74 6978 4 affect affect VBP cord-015021-pol2qm74 6978 5 the the DT cord-015021-pol2qm74 6978 6 transloeation transloeation NN cord-015021-pol2qm74 6978 7 process process NN cord-015021-pol2qm74 6978 8 . . . cord-015021-pol2qm74 6979 1 Addition addition NN cord-015021-pol2qm74 6979 2 of of IN cord-015021-pol2qm74 6979 3 arginlne arginlne NNP cord-015021-pol2qm74 6979 4 to to IN cord-015021-pol2qm74 6979 5 the the DT cord-015021-pol2qm74 6979 6 diet diet NN cord-015021-pol2qm74 6979 7 significantly significantly RB cord-015021-pol2qm74 6979 8 improves improve VBZ cord-015021-pol2qm74 6979 9 the the DT cord-015021-pol2qm74 6979 10 ability ability NN cord-015021-pol2qm74 6979 11 to to TO cord-015021-pol2qm74 6979 12 kill kill VB cord-015021-pol2qm74 6979 13 translocated translocate VBN cord-015021-pol2qm74 6979 14 organisms organism NNS cord-015021-pol2qm74 6979 15 . . . cord-015021-pol2qm74 6980 1 However however RB cord-015021-pol2qm74 6980 2 . . . cord-015021-pol2qm74 6981 1 translooetion translooetion NN cord-015021-pol2qm74 6981 2 across across IN cord-015021-pol2qm74 6981 3 the the DT cord-015021-pol2qm74 6981 4 gastrointestinal gastrointestinal JJ cord-015021-pol2qm74 6981 5 barrier barrier NN cord-015021-pol2qm74 6981 6 is be VBZ cord-015021-pol2qm74 6981 7 not not RB cord-015021-pol2qm74 6981 8 affected affect VBN cord-015021-pol2qm74 6981 9 . . . cord-015021-pol2qm74 6982 1 In in IN cord-015021-pol2qm74 6982 2 contrast contrast NN cord-015021-pol2qm74 6982 3 , , , cord-015021-pol2qm74 6982 4 glutamine glutamine NN cord-015021-pol2qm74 6982 5 diminishes diminish VBZ cord-015021-pol2qm74 6982 6 the the DT cord-015021-pol2qm74 6982 7 rate rate NN cord-015021-pol2qm74 6982 8 of of IN cord-015021-pol2qm74 6982 9 translooation translooation NN cord-015021-pol2qm74 6982 10 across across IN cord-015021-pol2qm74 6982 11 the the DT cord-015021-pol2qm74 6982 12 Imtestinal Imtestinal NNP cord-015021-pol2qm74 6982 13 barrier barrier NN cord-015021-pol2qm74 6982 14 and and CC cord-015021-pol2qm74 6982 15 also also RB cord-015021-pol2qm74 6982 16 improves improve VBZ cord-015021-pol2qm74 6982 17 killing killing NN cord-015021-pol2qm74 6982 18 of of IN cord-015021-pol2qm74 6982 19 the the DT cord-015021-pol2qm74 6982 20 beetarla beetarla NN cord-015021-pol2qm74 6982 21 that that WDT cord-015021-pol2qm74 6982 22 do do VBP cord-015021-pol2qm74 6982 23 translooate translooate NN cord-015021-pol2qm74 6982 24 . . . cord-015021-pol2qm74 6983 1 The the DT cord-015021-pol2qm74 6983 2 omega omega NN cord-015021-pol2qm74 6983 3 3 3 CD cord-015021-pol2qm74 6983 4 fatty fatty JJ cord-015021-pol2qm74 6983 5 acids acid NNS cord-015021-pol2qm74 6983 6 in in IN cord-015021-pol2qm74 6983 7 the the DT cord-015021-pol2qm74 6983 8 form form NN cord-015021-pol2qm74 6983 9 of of IN cord-015021-pol2qm74 6983 10 fish fish NN cord-015021-pol2qm74 6983 11 oil oil NN cord-015021-pol2qm74 6983 12 slightly slightly RB cord-015021-pol2qm74 6983 13 decrease decrease VBP cord-015021-pol2qm74 6983 14 the the DT cord-015021-pol2qm74 6983 15 rate rate NN cord-015021-pol2qm74 6983 16 of of IN cord-015021-pol2qm74 6983 17 translocation translocation NN cord-015021-pol2qm74 6983 18 but but CC cord-015021-pol2qm74 6983 19 more more RBR cord-015021-pol2qm74 6983 20 significantly significantly RB cord-015021-pol2qm74 6983 21 increase increase VB cord-015021-pol2qm74 6983 22 the the DT cord-015021-pol2qm74 6983 23 ability ability NN cord-015021-pol2qm74 6983 24 of of IN cord-015021-pol2qm74 6983 25 the the DT cord-015021-pol2qm74 6983 26 animal animal NN cord-015021-pol2qm74 6983 27 to to TO cord-015021-pol2qm74 6983 28 kill kill VB cord-015021-pol2qm74 6983 29 translo translo NNP cord-015021-pol2qm74 6983 30 ~ ~ NFP cord-015021-pol2qm74 6983 31 ated ate VBN cord-015021-pol2qm74 6983 32 organisms organism NNS cord-015021-pol2qm74 6983 33 , , , cord-015021-pol2qm74 6983 34 All all DT cord-015021-pol2qm74 6983 35 three three CD cord-015021-pol2qm74 6983 36 dietary dietary JJ cord-015021-pol2qm74 6983 37 additives additive NNS cord-015021-pol2qm74 6983 38 , , , cord-015021-pol2qm74 6983 39 i.e. i.e. FW cord-015021-pol2qm74 6983 40 argini argini NNP cord-015021-pol2qm74 6983 41 ~ ~ NNP cord-015021-pol2qm74 6983 42 e e NNP cord-015021-pol2qm74 6983 43 , , , cord-015021-pol2qm74 6983 44 glu glu NNP cord-015021-pol2qm74 6983 45 = = SYM cord-015021-pol2qm74 6983 46 amine amine NN cord-015021-pol2qm74 6983 47 and and CC cord-015021-pol2qm74 6983 48 fish fish NN cord-015021-pol2qm74 6983 49 nil nil NN cord-015021-pol2qm74 6983 50 . . . cord-015021-pol2qm74 6984 1 significantly significantly RB cord-015021-pol2qm74 6984 2 improve improve VB cord-015021-pol2qm74 6984 3 survival survival NN cord-015021-pol2qm74 6984 4 , , , cord-015021-pol2qm74 6984 5 hut hut NN cord-015021-pol2qm74 6984 6 adding add VBG cord-015021-pol2qm74 6984 7 glyoine glyoine NN cord-015021-pol2qm74 6984 8 or or CC cord-015021-pol2qm74 6984 9 medium medium JJ cord-015021-pol2qm74 6984 10 chain chain NN cord-015021-pol2qm74 6984 11 triglyeeridem triglyeeridem NNS cord-015021-pol2qm74 6984 12 do do VBP cord-015021-pol2qm74 6984 13 not not RB cord-015021-pol2qm74 6984 14 , , , cord-015021-pol2qm74 6984 15 Combinations Combinations NNPS cord-015021-pol2qm74 6984 16 of of IN cord-015021-pol2qm74 6984 17 srginine srginine NNP cord-015021-pol2qm74 6984 18 and and CC cord-015021-pol2qm74 6984 19 glutamlns glutamlns NNP cord-015021-pol2qm74 6984 20 , , , cord-015021-pol2qm74 6984 21 glutamine glutamine NN cord-015021-pol2qm74 6984 22 and and CC cord-015021-pol2qm74 6984 23 fish fish NN cord-015021-pol2qm74 6984 24 oil oil NN cord-015021-pol2qm74 6984 25 , , , cord-015021-pol2qm74 6984 26 and and CC cord-015021-pol2qm74 6984 27 fish fish VB cord-015021-pol2qm74 6984 28 ell ell NNP cord-015021-pol2qm74 6984 29 end end NN cord-015021-pol2qm74 6984 30 arginine arginine NN cord-015021-pol2qm74 6984 31 each each DT cord-015021-pol2qm74 6984 32 improve improve VBP cord-015021-pol2qm74 6984 33 survival survival NN cord-015021-pol2qm74 6984 34 , , , cord-015021-pol2qm74 6984 35 and and CC cord-015021-pol2qm74 6984 36 to to IN cord-015021-pol2qm74 6984 37 a a DT cord-015021-pol2qm74 6984 38 greater great JJR cord-015021-pol2qm74 6984 39 degree degree NN cord-015021-pol2qm74 6984 40 than than IN cord-015021-pol2qm74 6984 41 a a DT cord-015021-pol2qm74 6984 42 combination combination NN cord-015021-pol2qm74 6984 43 of of IN cord-015021-pol2qm74 6984 44 all all DT cord-015021-pol2qm74 6984 45 three three CD cord-015021-pol2qm74 6984 46 . . . cord-015021-pol2qm74 6985 1 These these DT cord-015021-pol2qm74 6985 2 studies study NNS cord-015021-pol2qm74 6985 3 add add VBP cord-015021-pol2qm74 6985 4 further further JJ cord-015021-pol2qm74 6985 5 evidence evidence NN cord-015021-pol2qm74 6985 6 that that IN cord-015021-pol2qm74 6985 7 translocation translocation NN cord-015021-pol2qm74 6985 8 is be VBZ cord-015021-pol2qm74 6985 9 an an DT cord-015021-pol2qm74 6985 10 important important JJ cord-015021-pol2qm74 6985 11 determinant determinant NN cord-015021-pol2qm74 6985 12 of of IN cord-015021-pol2qm74 6985 13 survival survival NN cord-015021-pol2qm74 6985 14 after after IN cord-015021-pol2qm74 6985 15 injury injury NN cord-015021-pol2qm74 6985 16 , , , cord-015021-pol2qm74 6985 17 Early early RB cord-015021-pol2qm74 6985 18 feeding feed VBG cord-015021-pol2qm74 6985 19 with with IN cord-015021-pol2qm74 6985 20 immunonutrlent immunonutrlent NN cord-015021-pol2qm74 6985 21 enriched enrich VBN cord-015021-pol2qm74 6985 22 dices dice NNS cord-015021-pol2qm74 6985 23 will will MD cord-015021-pol2qm74 6985 24 improve improve VB cord-015021-pol2qm74 6985 25 survival survival NN cord-015021-pol2qm74 6985 26 and and CC cord-015021-pol2qm74 6985 27 dsarease dsarease NN cord-015021-pol2qm74 6985 28 transloeation transloeation NN cord-015021-pol2qm74 6985 29 to to IN cord-015021-pol2qm74 6985 30 varying vary VBG cord-015021-pol2qm74 6985 31 degrees degree NNS cord-015021-pol2qm74 6985 32 , , , cord-015021-pol2qm74 6985 33 depending depend VBG cord-015021-pol2qm74 6985 34 upon upon IN cord-015021-pol2qm74 6985 35 the the DT cord-015021-pol2qm74 6985 36 nutrients nutrient NNS cord-015021-pol2qm74 6985 37 provided provide VBN cord-015021-pol2qm74 6985 38 . . . cord-015021-pol2qm74 6986 1 OBJECTIVES objectives NN cord-015021-pol2qm74 6986 2 : : : cord-015021-pol2qm74 6987 1 We -PRON- PRP cord-015021-pol2qm74 6987 2 studied study VBD cord-015021-pol2qm74 6987 3 effects effect NNS cord-015021-pol2qm74 6987 4 of of IN cord-015021-pol2qm74 6987 5 supplementing supplement VBG cord-015021-pol2qm74 6987 6 a a DT cord-015021-pol2qm74 6987 7 commercial commercial JJ cord-015021-pol2qm74 6987 8 enteral enteral JJ cord-015021-pol2qm74 6987 9 diet diet NN cord-015021-pol2qm74 6987 10 , , , cord-015021-pol2qm74 6987 11 Impact impact NN cord-015021-pol2qm74 6987 12 R R NNP cord-015021-pol2qm74 6987 13 ( ( -LRB- cord-015021-pol2qm74 6987 14 IMP IMP NNP cord-015021-pol2qm74 6987 15 , , , cord-015021-pol2qm74 6987 16 Sander Sander NNP cord-015021-pol2qm74 6987 17 Nutr Nutr NNP cord-015021-pol2qm74 6987 18 lnc lnc NNP cord-015021-pol2qm74 6987 19 ) ) -RRB- cord-015021-pol2qm74 6987 20 , , , cord-015021-pol2qm74 6987 21 with with IN cord-015021-pol2qm74 6987 22 fiber fiber NN cord-015021-pol2qm74 6987 23 ( ( -LRB- cord-015021-pol2qm74 6987 24 IMP IMP NNP cord-015021-pol2qm74 6987 25 / / SYM cord-015021-pol2qm74 6987 26 FIB FIB NNP cord-015021-pol2qm74 6987 27 ) ) -RRB- cord-015021-pol2qm74 6987 28 or or CC cord-015021-pol2qm74 6987 29 alanyl alanyl NN cord-015021-pol2qm74 6987 30 - - HYPH cord-015021-pol2qm74 6987 31 glutamine glutamine NN cord-015021-pol2qm74 6987 32 ( ( -LRB- cord-015021-pol2qm74 6987 33 IMP IMP NNP cord-015021-pol2qm74 6987 34 / / SYM cord-015021-pol2qm74 6987 35 AG AG NNP cord-015021-pol2qm74 6987 36 , , , cord-015021-pol2qm74 6987 37 exogenous exogenous JJ cord-015021-pol2qm74 6987 38 glutamine glutamine NN cord-015021-pol2qm74 6987 39 ( ( -LRB- cord-015021-pol2qm74 6987 40 GLN GLN NNP cord-015021-pol2qm74 6987 41 ) ) -RRB- cord-015021-pol2qm74 6987 42 14 14 CD cord-015021-pol2qm74 6987 43 gms gms NN cord-015021-pol2qm74 6987 44 / / SYM cord-015021-pol2qm74 6987 45 L L NNP cord-015021-pol2qm74 6987 46 ) ) -RRB- cord-015021-pol2qm74 6987 47 on on IN cord-015021-pol2qm74 6987 48 influencing influence VBG cord-015021-pol2qm74 6987 49 the the DT cord-015021-pol2qm74 6987 50 incidence incidence NN cord-015021-pol2qm74 6987 51 of of IN cord-015021-pol2qm74 6987 52 BT BT NNP cord-015021-pol2qm74 6987 53 to to IN cord-015021-pol2qm74 6987 54 mesenteric mesenteric JJ cord-015021-pol2qm74 6987 55 lymph lymph NN cord-015021-pol2qm74 6987 56 nodes node NNS cord-015021-pol2qm74 6987 57 ( ( -LRB- cord-015021-pol2qm74 6987 58 MLN mln NN cord-015021-pol2qm74 6987 59 ) ) -RRB- cord-015021-pol2qm74 6987 60 in in IN cord-015021-pol2qm74 6987 61 burned burn VBN cord-015021-pol2qm74 6987 62 mice mouse NNS cord-015021-pol2qm74 6987 63 . . . cord-015021-pol2qm74 6988 1 Fiber fiber NN cord-015021-pol2qm74 6988 2 has have VBZ cord-015021-pol2qm74 6988 3 been be VBN cord-015021-pol2qm74 6988 4 shown show VBN cord-015021-pol2qm74 6988 5 to to TO cord-015021-pol2qm74 6988 6 improve improve VB cord-015021-pol2qm74 6988 7 GI GI NNP cord-015021-pol2qm74 6988 8 integrity integrity NN cord-015021-pol2qm74 6988 9 under under IN cord-015021-pol2qm74 6988 10 certain certain JJ cord-015021-pol2qm74 6988 11 stress stress NN cord-015021-pol2qm74 6988 12 / / SYM cord-015021-pol2qm74 6988 13 treatment treatment NN cord-015021-pol2qm74 6988 14 conditions condition NNS cord-015021-pol2qm74 6988 15 . . . cord-015021-pol2qm74 6989 1 The the DT cord-015021-pol2qm74 6989 2 dipeptide dipeptide JJ cord-015021-pol2qm74 6989 3 AG AG NNP cord-015021-pol2qm74 6989 4 is be VBZ cord-015021-pol2qm74 6989 5 a a DT cord-015021-pol2qm74 6989 6 water water NN cord-015021-pol2qm74 6989 7 - - HYPH cord-015021-pol2qm74 6989 8 stable stable JJ cord-015021-pol2qm74 6989 9 source source NN cord-015021-pol2qm74 6989 10 of of IN cord-015021-pol2qm74 6989 11 GLN GLN NNP cord-015021-pol2qm74 6989 12 , , , cord-015021-pol2qm74 6989 13 which which WDT cord-015021-pol2qm74 6989 14 is be VBZ cord-015021-pol2qm74 6989 15 a a DT cord-015021-pol2qm74 6989 16 specific specific JJ cord-015021-pol2qm74 6989 17 fuel fuel NN cord-015021-pol2qm74 6989 18 for for IN cord-015021-pol2qm74 6989 19 many many JJ cord-015021-pol2qm74 6989 20 cells cell NNS cord-015021-pol2qm74 6989 21 including include VBG cord-015021-pol2qm74 6989 22 enterocytes enterocyte NNS cord-015021-pol2qm74 6989 23 . . . cord-015021-pol2qm74 6990 1 TraumaCal TraumaCal NNP cord-015021-pol2qm74 6990 2 ( ( -LRB- cord-015021-pol2qm74 6990 3 TRCAL TRCAL NNP cord-015021-pol2qm74 6990 4 ) ) -RRB- cord-015021-pol2qm74 6990 5 , , , cord-015021-pol2qm74 6990 6 a a DT cord-015021-pol2qm74 6990 7 high high JJ cord-015021-pol2qm74 6990 8 - - HYPH cord-015021-pol2qm74 6990 9 protein protein NN cord-015021-pol2qm74 6990 10 , , , cord-015021-pol2qm74 6990 11 high high JJ cord-015021-pol2qm74 6990 12 - - HYPH cord-015021-pol2qm74 6990 13 fat fat NN cord-015021-pol2qm74 6990 14 enteral enteral JJ cord-015021-pol2qm74 6990 15 diet diet NN cord-015021-pol2qm74 6990 16 ( ( -LRB- cord-015021-pol2qm74 6990 17 Mead Mead NNP cord-015021-pol2qm74 6990 18 Johnson Johnson NNP cord-015021-pol2qm74 6990 19 Iuc Iuc NNP cord-015021-pol2qm74 6990 20 ) ) -RRB- cord-015021-pol2qm74 6990 21 , , , cord-015021-pol2qm74 6990 22 was be VBD cord-015021-pol2qm74 6990 23 also also RB cord-015021-pol2qm74 6990 24 studied study VBN cord-015021-pol2qm74 6990 25 , , , cord-015021-pol2qm74 6990 26 as as RB cord-015021-pol2qm74 6990 27 well well RB cord-015021-pol2qm74 6990 28 as as IN cord-015021-pol2qm74 6990 29 Rodent Rodent NNP cord-015021-pol2qm74 6990 30 Chow Chow NNP cord-015021-pol2qm74 6990 31 ( ( -LRB- cord-015021-pol2qm74 6990 32 Harlan Harlan NNP cord-015021-pol2qm74 6990 33 Teklad Teklad NNP cord-015021-pol2qm74 6990 34 Inc Inc NNP cord-015021-pol2qm74 6990 35 ) ) -RRB- cord-015021-pol2qm74 6990 36 , , , cord-015021-pol2qm74 6990 37 which which WDT cord-015021-pol2qm74 6990 38 contains contain VBZ cord-015021-pol2qm74 6990 39 very very RB cord-015021-pol2qm74 6990 40 high high JJ cord-015021-pol2qm74 6990 41 protein protein NN cord-015021-pol2qm74 6990 42 & & CC cord-015021-pol2qm74 6990 43 fiber fiber NN cord-015021-pol2qm74 6990 44 . . . cord-015021-pol2qm74 6991 1 METHODS methods NN cord-015021-pol2qm74 6991 2 : : : cord-015021-pol2qm74 6992 1 Anesthetized anesthetize VBN cord-015021-pol2qm74 6992 2 CF-1 CF-1 NNP cord-015021-pol2qm74 6992 3 mice mouse NNS cord-015021-pol2qm74 6992 4 aged age VBN cord-015021-pol2qm74 6992 5 8 8 CD cord-015021-pol2qm74 6992 6 - - SYM cord-015021-pol2qm74 6992 7 12 12 CD cord-015021-pol2qm74 6992 8 wks wks NN cord-015021-pol2qm74 6992 9 received receive VBD cord-015021-pol2qm74 6992 10 32 32 CD cord-015021-pol2qm74 6992 11 % % NN cord-015021-pol2qm74 6992 12 TBSA TBSA NNP cord-015021-pol2qm74 6992 13 fullthickness fullthickness JJ cord-015021-pol2qm74 6992 14 dorsal dorsal NNP cord-015021-pol2qm74 6992 15 burns burn NNS cord-015021-pol2qm74 6992 16 & & CC cord-015021-pol2qm74 6992 17 were be VBD cord-015021-pol2qm74 6992 18 resuscitated resuscitate VBN cord-015021-pol2qm74 6992 19 with with IN cord-015021-pol2qm74 6992 20 2 2 CD cord-015021-pol2qm74 6992 21 cc cc NN cord-015021-pol2qm74 6992 22 ip ip NN cord-015021-pol2qm74 6992 23 saline saline NN cord-015021-pol2qm74 6992 24 . . . cord-015021-pol2qm74 6993 1 Diets diet NNS cord-015021-pol2qm74 6993 2 were be VBD cord-015021-pol2qm74 6993 3 allowed allow VBN cord-015021-pol2qm74 6993 4 ad ad NN cord-015021-pol2qm74 6993 5 lib lib NN cord-015021-pol2qm74 6993 6 ; ; : cord-015021-pol2qm74 6993 7 caloric caloric JJ cord-015021-pol2qm74 6993 8 intakes intake NNS cord-015021-pol2qm74 6993 9 were be VBD cord-015021-pol2qm74 6993 10 comparable comparable JJ cord-015021-pol2qm74 6993 11 in in IN cord-015021-pol2qm74 6993 12 all all DT cord-015021-pol2qm74 6993 13 Gps Gps NNP cord-015021-pol2qm74 6993 14 except except IN cord-015021-pol2qm74 6993 15 fasted fast VBN cord-015021-pol2qm74 6993 16 Gp Gp NNP cord-015021-pol2qm74 6993 17 ( ( -LRB- cord-015021-pol2qm74 6993 18 fast fast JJ cord-015021-pol2qm74 6993 19 24 24 CD cord-015021-pol2qm74 6993 20 hrs hrs NN cord-015021-pol2qm74 6993 21 , , , cord-015021-pol2qm74 6993 22 Chow Chow NNP cord-015021-pol2qm74 6993 23 24 24 CD cord-015021-pol2qm74 6993 24 hrs hrs NN cord-015021-pol2qm74 6993 25 ) ) -RRB- cord-015021-pol2qm74 6993 26 . . . cord-015021-pol2qm74 6994 1 At at IN cord-015021-pol2qm74 6994 2 48 48 CD cord-015021-pol2qm74 6994 3 hrs hrs NN cord-015021-pol2qm74 6994 4 postburn postburn NN cord-015021-pol2qm74 6994 5 MLN MLN NNP cord-015021-pol2qm74 6994 6 were be VBD cord-015021-pol2qm74 6994 7 sterily sterily RB cord-015021-pol2qm74 6994 8 removed remove VBN cord-015021-pol2qm74 6994 9 , , , cord-015021-pol2qm74 6994 10 homogenized homogenize VBN cord-015021-pol2qm74 6994 11 and and CC cord-015021-pol2qm74 6994 12 plated plate VBN cord-015021-pol2qm74 6994 13 on on IN cord-015021-pol2qm74 6994 14 heart heart NN cord-015021-pol2qm74 6994 15 brain brain NN cord-015021-pol2qm74 6994 16 infusion infusion NN cord-015021-pol2qm74 6994 17 agar agar NN cord-015021-pol2qm74 6994 18 ; ; : cord-015021-pol2qm74 6994 19 CFU CFU NNP cord-015021-pol2qm74 6994 20 / / SYM cord-015021-pol2qm74 6994 21 g g NN cord-015021-pol2qm74 6994 22 MLN mln NN cord-015021-pol2qm74 6994 23 tissue tissue NN cord-015021-pol2qm74 6994 24 were be VBD cord-015021-pol2qm74 6994 25 determined determine VBN cord-015021-pol2qm74 6994 26 . . . cord-015021-pol2qm74 6995 1 BT BT NNP cord-015021-pol2qm74 6995 2 was be VBD cord-015021-pol2qm74 6995 3 analyzed analyze VBN cord-015021-pol2qm74 6995 4 by by IN cord-015021-pol2qm74 6995 5 Fishers Fishers NNPS cord-015021-pol2qm74 6995 6 Exact Exact NNP cord-015021-pol2qm74 6995 7 Test Test NNP cord-015021-pol2qm74 6995 8 , , , cord-015021-pol2qm74 6995 9 CFU CFU NNP cord-015021-pol2qm74 6995 10 / / SYM cord-015021-pol2qm74 6995 11 g g NN cord-015021-pol2qm74 6995 12 by by IN cord-015021-pol2qm74 6995 13 ANOVA ANOVA NNP cord-015021-pol2qm74 6995 14 - - HYPH cord-015021-pol2qm74 6995 15 Bonferroni Bonferroni NNP cord-015021-pol2qm74 6995 16 . . . cord-015021-pol2qm74 6996 1 * * NFP cord-015021-pol2qm74 6996 2 P<0.01 P<0.01 NNS cord-015021-pol2qm74 6996 3 , , . cord-015021-pol2qm74 6997 1 * * NFP cord-015021-pol2qm74 6997 2 * * NFP cord-015021-pol2qm74 6997 3 P<0.05 P<0.05 NNS cord-015021-pol2qm74 6997 4 compared compare VBN cord-015021-pol2qm74 6997 5 to to IN cord-015021-pol2qm74 6997 6 IMP IMP NNP cord-015021-pol2qm74 6997 7 and and CC cord-015021-pol2qm74 6997 8 Burn burn VB cord-015021-pol2qm74 6997 9 - - HYPH cord-015021-pol2qm74 6997 10 Fast Fast NNP cord-015021-pol2qm74 6997 11 Gps Gps NNP cord-015021-pol2qm74 6997 12 . . . cord-015021-pol2qm74 6998 1 Background background NN cord-015021-pol2qm74 6998 2 . . . cord-015021-pol2qm74 6999 1 Infectious infectious JJ cord-015021-pol2qm74 6999 2 complications complication NNS cord-015021-pol2qm74 6999 3 following follow VBG cord-015021-pol2qm74 6999 4 trauma trauma NN cord-015021-pol2qm74 6999 5 , , , cord-015021-pol2qm74 6999 6 major major JJ cord-015021-pol2qm74 6999 7 operation operation NN cord-015021-pol2qm74 6999 8 , , , cord-015021-pol2qm74 6999 9 or or CC cord-015021-pol2qm74 6999 10 critical critical JJ cord-015021-pol2qm74 6999 11 illness illness NN cord-015021-pol2qm74 6999 12 adversely adversely RB cord-015021-pol2qm74 6999 13 affect affect VBP cord-015021-pol2qm74 6999 14 hospital hospital NN cord-015021-pol2qm74 6999 15 cost cost NN cord-015021-pol2qm74 6999 16 and and CC cord-015021-pol2qm74 6999 17 length length NN cord-015021-pol2qm74 6999 18 of of IN cord-015021-pol2qm74 6999 19 stay stay NN cord-015021-pol2qm74 6999 20 ( ( -LRB- cord-015021-pol2qm74 6999 21 LOS LOS NNP cord-015021-pol2qm74 6999 22 ) ) -RRB- cord-015021-pol2qm74 6999 23 . . . cord-015021-pol2qm74 7000 1 Some some DT cord-015021-pol2qm74 7000 2 key key JJ cord-015021-pol2qm74 7000 3 nutrients nutrient NNS cord-015021-pol2qm74 7000 4 have have VBP cord-015021-pol2qm74 7000 5 been be VBN cord-015021-pol2qm74 7000 6 shown show VBN cord-015021-pol2qm74 7000 7 to to TO cord-015021-pol2qm74 7000 8 possess possess VB cord-015021-pol2qm74 7000 9 immune immune JJ cord-015021-pol2qm74 7000 10 enhancing enhance VBG cord-015021-pol2qm74 7000 11 properties property NNS cord-015021-pol2qm74 7000 12 . . . cord-015021-pol2qm74 7001 1 This this DT cord-015021-pol2qm74 7001 2 multicenter multicenter JJ cord-015021-pol2qm74 7001 3 trial trial NN cord-015021-pol2qm74 7001 4 was be VBD cord-015021-pol2qm74 7001 5 conducted conduct VBN cord-015021-pol2qm74 7001 6 to to TO cord-015021-pol2qm74 7001 7 determine determine VB cord-015021-pol2qm74 7001 8 if if IN cord-015021-pol2qm74 7001 9 early early JJ cord-015021-pol2qm74 7001 10 administration administration NN cord-015021-pol2qm74 7001 11 of of IN cord-015021-pol2qm74 7001 12 an an DT cord-015021-pol2qm74 7001 13 enteral enteral JJ cord-015021-pol2qm74 7001 14 formula formula NN cord-015021-pol2qm74 7001 15 supplemented supplement VBN cord-015021-pol2qm74 7001 16 with with IN cord-015021-pol2qm74 7001 17 arginine arginine NN cord-015021-pol2qm74 7001 18 , , , cord-015021-pol2qm74 7001 19 dietary dietary JJ cord-015021-pol2qm74 7001 20 nucleotides nucleotide NNS cord-015021-pol2qm74 7001 21 and and CC cord-015021-pol2qm74 7001 22 fish fish NN cord-015021-pol2qm74 7001 23 oil oil NN cord-015021-pol2qm74 7001 24 can can MD cord-015021-pol2qm74 7001 25 decrease decrease VB cord-015021-pol2qm74 7001 26 LOS LOS NNP cord-015021-pol2qm74 7001 27 and and CC cord-015021-pol2qm74 7001 28 infectious infectious JJ cord-015021-pol2qm74 7001 29 complications complication NNS cord-015021-pol2qm74 7001 30 in in IN cord-015021-pol2qm74 7001 31 ICU ICU NNP cord-015021-pol2qm74 7001 32 patients patient NNS cord-015021-pol2qm74 7001 33 . . . cord-015021-pol2qm74 7002 1 Methods method NNS cord-015021-pol2qm74 7002 2 . . . cord-015021-pol2qm74 7003 1 This this DT cord-015021-pol2qm74 7003 2 was be VBD cord-015021-pol2qm74 7003 3 a a DT cord-015021-pol2qm74 7003 4 prospective prospective JJ cord-015021-pol2qm74 7003 5 , , , cord-015021-pol2qm74 7003 6 randomized randomized JJ cord-015021-pol2qm74 7003 7 , , , cord-015021-pol2qm74 7003 8 double double JJ cord-015021-pol2qm74 7003 9 - - HYPH cord-015021-pol2qm74 7003 10 blind blind JJ cord-015021-pol2qm74 7003 11 study study NN cord-015021-pol2qm74 7003 12 of of IN cord-015021-pol2qm74 7003 13 326 326 CD cord-015021-pol2qm74 7003 14 adult adult NN cord-015021-pol2qm74 7003 15 ICU ICU NNP cord-015021-pol2qm74 7003 16 patients patient NNS cord-015021-pol2qm74 7003 17 who who WP cord-015021-pol2qm74 7003 18 required require VBD cord-015021-pol2qm74 7003 19 enteral enteral NN cord-015021-pol2qm74 7003 20 feeding feed VBG cord-015021-pol2qm74 7003 21 for for IN cord-015021-pol2qm74 7003 22 > > $ cord-015021-pol2qm74 7003 23 7 7 CD cord-015021-pol2qm74 7003 24 days day NNS cord-015021-pol2qm74 7003 25 . . . cord-015021-pol2qm74 7004 1 Patients patient NNS cord-015021-pol2qm74 7004 2 entered enter VBD cord-015021-pol2qm74 7004 3 the the DT cord-015021-pol2qm74 7004 4 study study NN cord-015021-pol2qm74 7004 5 within within IN cord-015021-pol2qm74 7004 6 48 48 CD cord-015021-pol2qm74 7004 7 hr hr NN cord-015021-pol2qm74 7004 8 of of IN cord-015021-pol2qm74 7004 9 the the DT cord-015021-pol2qm74 7004 10 event event NN cord-015021-pol2qm74 7004 11 , , , cord-015021-pol2qm74 7004 12 were be VBD cord-015021-pol2qm74 7004 13 stratified stratify VBN cord-015021-pol2qm74 7004 14 by by IN cord-015021-pol2qm74 7004 15 age age NN cord-015021-pol2qm74 7004 16 and and CC cord-015021-pol2qm74 7004 17 disease disease NN cord-015021-pol2qm74 7004 18 , , , cord-015021-pol2qm74 7004 19 and and CC cord-015021-pol2qm74 7004 20 were be VBD cord-015021-pol2qm74 7004 21 randomized randomize VBN cord-015021-pol2qm74 7004 22 to to TO cord-015021-pol2qm74 7004 23 receive receive VB cord-015021-pol2qm74 7004 24 either either CC cord-015021-pol2qm74 7004 25 the the DT cord-015021-pol2qm74 7004 26 supplemented supplement VBN cord-015021-pol2qm74 7004 27 formula formula NN cord-015021-pol2qm74 7004 28 ( ( -LRB- cord-015021-pol2qm74 7004 29 IMPACT IMPACT NNP cord-015021-pol2qm74 7004 30 ® ® NNPS cord-015021-pol2qm74 7004 31 ) ) -RRB- cord-015021-pol2qm74 7004 32 or or CC cord-015021-pol2qm74 7004 33 the the DT cord-015021-pol2qm74 7004 34 conventional conventional JJ cord-015021-pol2qm74 7004 35 formula formula NN cord-015021-pol2qm74 7004 36 ( ( -LRB- cord-015021-pol2qm74 7004 37 Osmolite Osmolite NNP cord-015021-pol2qm74 7004 38 ® ® NN cord-015021-pol2qm74 7004 39 HN HN NNP cord-015021-pol2qm74 7004 40 ) ) -RRB- cord-015021-pol2qm74 7004 41 . . . cord-015021-pol2qm74 7005 1 Feedings feeding NNS cord-015021-pol2qm74 7005 2 were be VBD cord-015021-pol2qm74 7005 3 initiated initiate VBN cord-015021-pol2qm74 7005 4 at at IN cord-015021-pol2qm74 7005 5 full full JJ cord-015021-pol2qm74 7005 6 strength strength NN cord-015021-pol2qm74 7005 7 and and CC cord-015021-pol2qm74 7005 8 advanced advance VBD cord-015021-pol2qm74 7005 9 to to IN cord-015021-pol2qm74 7005 10 at at RB cord-015021-pol2qm74 7005 11 least least RBS cord-015021-pol2qm74 7005 12 60 60 CD cord-015021-pol2qm74 7005 13 ml ml NN cord-015021-pol2qm74 7005 14 / / SYM cord-015021-pol2qm74 7005 15 hr hr NN cord-015021-pol2qm74 7005 16 by by IN cord-015021-pol2qm74 7005 17 96 96 CD cord-015021-pol2qm74 7005 18 hr hr NN cord-015021-pol2qm74 7005 19 after after IN cord-015021-pol2qm74 7005 20 event event NN cord-015021-pol2qm74 7005 21 . . . cord-015021-pol2qm74 7006 1 Results result NNS cord-015021-pol2qm74 7006 2 . . . cord-015021-pol2qm74 7007 1 Both both DT cord-015021-pol2qm74 7007 2 groups group NNS cord-015021-pol2qm74 7007 3 tolerated tolerate VBD cord-015021-pol2qm74 7007 4 administration administration NN cord-015021-pol2qm74 7007 5 of of IN cord-015021-pol2qm74 7007 6 formula formula NNP cord-015021-pol2qm74 7007 7 well well RB cord-015021-pol2qm74 7007 8 . . . cord-015021-pol2qm74 7008 1 For for IN cord-015021-pol2qm74 7008 2 patients patient NNS cord-015021-pol2qm74 7008 3 fed feed VBN cord-015021-pol2qm74 7008 4 > > XX cord-015021-pol2qm74 7008 5 7 7 CD cord-015021-pol2qm74 7008 6 days day NNS cord-015021-pol2qm74 7008 7 , , , cord-015021-pol2qm74 7008 8 the the DT cord-015021-pol2qm74 7008 9 median median JJ cord-015021-pol2qm74 7008 10 LOS LOS NNP cord-015021-pol2qm74 7008 11 was be VBD cord-015021-pol2qm74 7008 12 25 25 CD cord-015021-pol2qm74 7008 13 % % NN cord-015021-pol2qm74 7008 14 shorter short JJR cord-015021-pol2qm74 7009 1 ( ( -LRB- cord-015021-pol2qm74 7009 2 p p NN cord-015021-pol2qm74 7009 3 = = SYM cord-015021-pol2qm74 7009 4 O.OL O.OL NNP cord-015021-pol2qm74 7009 5 ) ) -RRB- cord-015021-pol2qm74 7009 6 for for IN cord-015021-pol2qm74 7009 7 the the DT cord-015021-pol2qm74 7009 8 -- -- : cord-015021-pol2qm74 7009 9 supplemented supplement VBN cord-015021-pol2qm74 7009 10 group group NN cord-015021-pol2qm74 7009 11 ( ( -LRB- cord-015021-pol2qm74 7009 12 21 21 CD cord-015021-pol2qm74 7009 13 days day NNS cord-015021-pol2qm74 7009 14 ) ) -RRB- cord-015021-pol2qm74 7010 1 compared compare VBN cord-015021-pol2qm74 7010 2 to to IN cord-015021-pol2qm74 7010 3 the the DT cord-015021-pol2qm74 7010 4 conventional conventional JJ cord-015021-pol2qm74 7010 5 group group NN cord-015021-pol2qm74 7010 6 ( ( -LRB- cord-015021-pol2qm74 7010 7 28 28 CD cord-015021-pol2qm74 7010 8 days day NNS cord-015021-pol2qm74 7010 9 ) ) -RRB- cord-015021-pol2qm74 7010 10 . . . cord-015021-pol2qm74 7011 1 The the DT cord-015021-pol2qm74 7011 2 incidence incidence NN cord-015021-pol2qm74 7011 3 of of IN cord-015021-pol2qm74 7011 4 most most JJS cord-015021-pol2qm74 7011 5 infectious infectious JJ cord-015021-pol2qm74 7011 6 complications complication NNS cord-015021-pol2qm74 7011 7 was be VBD cord-015021-pol2qm74 7011 8 lower low JJR cord-015021-pol2qm74 7011 9 in in IN cord-015021-pol2qm74 7011 10 the the DT cord-015021-pol2qm74 7011 11 supplemented supplement VBN cord-015021-pol2qm74 7011 12 group group NN cord-015021-pol2qm74 7011 13 , , , cord-015021-pol2qm74 7011 14 but but CC cord-015021-pol2qm74 7011 15 this this DT cord-015021-pol2qm74 7011 16 difference difference NN cord-015021-pol2qm74 7011 17 reached reach VBD cord-015021-pol2qm74 7011 18 significance significance NN cord-015021-pol2qm74 7011 19 only only RB cord-015021-pol2qm74 7011 20 for for IN cord-015021-pol2qm74 7011 21 urinary urinary JJ cord-015021-pol2qm74 7011 22 tract tract NN cord-015021-pol2qm74 7011 23 infections infection NNS cord-015021-pol2qm74 7012 1 ( ( -LRB- cord-015021-pol2qm74 7012 2 p p NN cord-015021-pol2qm74 7012 3 = = SYM cord-015021-pol2qm74 7012 4 O.O05 o.o05 NN cord-015021-pol2qm74 7012 5 ) ) -RRB- cord-015021-pol2qm74 7012 6 . . . cord-015021-pol2qm74 7013 1 The the DT cord-015021-pol2qm74 7013 2 supplemented supplemented JJ cord-015021-pol2qm74 7013 3 group group NN cord-015021-pol2qm74 7013 4 had have VBD cord-015021-pol2qm74 7013 5 a a DT cord-015021-pol2qm74 7013 6 significantly significantly RB cord-015021-pol2qm74 7013 7 shorter short JJR cord-015021-pol2qm74 7013 8 LOS LOS NNP cord-015021-pol2qm74 7013 9 from from IN cord-015021-pol2qm74 7013 10 onset onset NN cord-015021-pol2qm74 7013 11 of of IN cord-015021-pol2qm74 7013 12 infectious infectious JJ cord-015021-pol2qm74 7013 13 complication complication NN cord-015021-pol2qm74 7013 14 until until IN cord-015021-pol2qm74 7013 15 discharge discharge NN cord-015021-pol2qm74 7013 16 for for IN cord-015021-pol2qm74 7013 17 patients patient NNS cord-015021-pol2qm74 7013 18 with with IN cord-015021-pol2qm74 7013 19 pneumonia pneumonia NN cord-015021-pol2qm74 7013 20 ( ( -LRB- cord-015021-pol2qm74 7013 21 19 19 CD cord-015021-pol2qm74 7013 22 vs. vs. IN cord-015021-pol2qm74 7013 23 27 27 CD cord-015021-pol2qm74 7013 24 days day NNS cord-015021-pol2qm74 7013 25 ) ) -RRB- cord-015021-pol2qm74 7013 26 and and CC cord-015021-pol2qm74 7013 27 skin skin NN cord-015021-pol2qm74 7013 28 / / SYM cord-015021-pol2qm74 7013 29 soft soft JJ cord-015021-pol2qm74 7013 30 tissue tissue NN cord-015021-pol2qm74 7013 31 infection infection NN cord-015021-pol2qm74 7013 32 ( ( -LRB- cord-015021-pol2qm74 7013 33 19 19 CD cord-015021-pol2qm74 7013 34 vs. vs. NN cord-015021-pol2qm74 7013 35 37 37 CD cord-015021-pol2qm74 7013 36 days day NNS cord-015021-pol2qm74 7013 37 ) ) -RRB- cord-015021-pol2qm74 7013 38 . . . cord-015021-pol2qm74 7014 1 Conclusions conclusion NNS cord-015021-pol2qm74 7014 2 . . . cord-015021-pol2qm74 7015 1 Administration administration NN cord-015021-pol2qm74 7015 2 of of IN cord-015021-pol2qm74 7015 3 the the DT cord-015021-pol2qm74 7015 4 supplemented supplement VBN cord-015021-pol2qm74 7015 5 formula formula NN cord-015021-pol2qm74 7015 6 was be VBD cord-015021-pol2qm74 7015 7 safe safe JJ cord-015021-pol2qm74 7015 8 and and CC cord-015021-pol2qm74 7015 9 well well RB cord-015021-pol2qm74 7015 10 tolerated tolerate VBN cord-015021-pol2qm74 7015 11 . . . cord-015021-pol2qm74 7016 1 When when WRB cord-015021-pol2qm74 7016 2 fed fed NNP cord-015021-pol2qm74 7016 3 > > XX cord-015021-pol2qm74 7016 4 7 7 CD cord-015021-pol2qm74 7016 5 days day NNS cord-015021-pol2qm74 7016 6 , , , cord-015021-pol2qm74 7016 7 it -PRON- PRP cord-015021-pol2qm74 7016 8 reduced reduce VBD cord-015021-pol2qm74 7016 9 the the DT cord-015021-pol2qm74 7016 10 incidence incidence NN cord-015021-pol2qm74 7016 11 of of IN cord-015021-pol2qm74 7016 12 most most JJS cord-015021-pol2qm74 7016 13 infectious infectious JJ cord-015021-pol2qm74 7016 14 complications complication NNS cord-015021-pol2qm74 7016 15 , , , cord-015021-pol2qm74 7016 16 and and CC cord-015021-pol2qm74 7016 17 significantly significantly RB cord-015021-pol2qm74 7016 18 reduced reduce VBN cord-015021-pol2qm74 7016 19 LOS LOS NNP cord-015021-pol2qm74 7016 20 . . . cord-015021-pol2qm74 7017 1 Materials material NNS cord-015021-pol2qm74 7017 2 and and CC cord-015021-pol2qm74 7017 3 Methods method NNS cord-015021-pol2qm74 7017 4 : : : cord-015021-pol2qm74 7017 5 Twenty twenty CD cord-015021-pol2qm74 7017 6 - - HYPH cord-015021-pol2qm74 7017 7 seven seven CD cord-015021-pol2qm74 7017 8 patients patient NNS cord-015021-pol2qm74 7017 9 were be VBD cord-015021-pol2qm74 7017 10 randomised randomise VBN cord-015021-pol2qm74 7017 11 into into IN cord-015021-pol2qm74 7017 12 3 3 CD cord-015021-pol2qm74 7017 13 groups group NNS cord-015021-pol2qm74 7017 14 ( ( -LRB- cord-015021-pol2qm74 7017 15 n= n= NNP cord-015021-pol2qm74 7017 16 9 9 CD cord-015021-pol2qm74 7017 17 each each DT cord-015021-pol2qm74 7017 18 ) ) -RRB- cord-015021-pol2qm74 7017 19 to to TO cord-015021-pol2qm74 7017 20 receive receive VB cord-015021-pol2qm74 7017 21 either either CC cord-015021-pol2qm74 7017 22 a a DT cord-015021-pol2qm74 7017 23 standard standard JJ cord-015021-pol2qm74 7017 24 enteral enteral JJ cord-015021-pol2qm74 7017 25 formula formula NN cord-015021-pol2qm74 7017 26 , , , cord-015021-pol2qm74 7017 27 the the DT cord-015021-pol2qm74 7017 28 same same JJ cord-015021-pol2qm74 7017 29 formula formula NN cord-015021-pol2qm74 7017 30 enriched enrich VBN cord-015021-pol2qm74 7017 31 with with IN cord-015021-pol2qm74 7017 32 arginine arginine NN cord-015021-pol2qm74 7017 33 , , , cord-015021-pol2qm74 7017 34 RNA RNA NNP cord-015021-pol2qm74 7017 35 and and CC cord-015021-pol2qm74 7017 36 omega omega NN cord-015021-pol2qm74 7017 37 3 3 CD cord-015021-pol2qm74 7017 38 fatty fatty JJ cord-015021-pol2qm74 7017 39 acids acid NNS cord-015021-pol2qm74 7017 40 ( ( -LRB- cord-015021-pol2qm74 7017 41 enriched enrich VBN cord-015021-pol2qm74 7017 42 group group NN cord-015021-pol2qm74 7017 43 ) ) -RRB- cord-015021-pol2qm74 7017 44 or or CC cord-015021-pol2qm74 7017 45 isonitrogen isonitrogen NNP cord-015021-pol2qm74 7017 46 , , , cord-015021-pol2qm74 7017 47 isocaloric isocaloric JJ cord-015021-pol2qm74 7017 48 parenteral parenteral JJ cord-015021-pol2qm74 7017 49 nutrition nutrition NN cord-015021-pol2qm74 7017 50 . . . cord-015021-pol2qm74 7018 1 Early early JJ cord-015021-pol2qm74 7018 2 enteral enteral JJ cord-015021-pol2qm74 7018 3 nutrition nutrition NN cord-015021-pol2qm74 7018 4 was be VBD cord-015021-pol2qm74 7018 5 started start VBN cord-015021-pol2qm74 7018 6 within within IN cord-015021-pol2qm74 7018 7 12 12 CD cord-015021-pol2qm74 7018 8 hours hour NNS cord-015021-pol2qm74 7018 9 following follow VBG cord-015021-pol2qm74 7018 10 surgery surgery NN cord-015021-pol2qm74 7018 11 ( ( -LRB- cord-015021-pol2qm74 7018 12 10 10 CD cord-015021-pol2qm74 7018 13 ml ml NN cord-015021-pol2qm74 7018 14 / / SYM cord-015021-pol2qm74 7018 15 hour hour NN cord-015021-pol2qm74 7018 16 ) ) -RRB- cord-015021-pol2qm74 7018 17 . . . cord-015021-pol2qm74 7019 1 It -PRON- PRP cord-015021-pol2qm74 7019 2 was be VBD cord-015021-pol2qm74 7019 3 progressively progressively RB cord-015021-pol2qm74 7019 4 increased increase VBN cord-015021-pol2qm74 7019 5 reaching reach VBG cord-015021-pol2qm74 7019 6 a a DT cord-015021-pol2qm74 7019 7 full full JJ cord-015021-pol2qm74 7019 8 regimen regimen NN cord-015021-pol2qm74 7019 9 on on IN cord-015021-pol2qm74 7019 10 day day NN cord-015021-pol2qm74 7019 11 4 4 CD cord-015021-pol2qm74 7019 12 . . . cord-015021-pol2qm74 7020 1 On on IN cord-015021-pol2qm74 7020 2 hospital hospital NN cord-015021-pol2qm74 7020 3 admission admission NN cord-015021-pol2qm74 7020 4 and and CC cord-015021-pol2qm74 7020 5 on on IN cord-015021-pol2qm74 7020 6 post post JJ cord-015021-pol2qm74 7020 7 - - JJ cord-015021-pol2qm74 7020 8 operative operative JJ cord-015021-pol2qm74 7020 9 day day NN cord-015021-pol2qm74 7020 10 1 1 CD cord-015021-pol2qm74 7020 11 and and CC cord-015021-pol2qm74 7020 12 8 8 CD cord-015021-pol2qm74 7020 13 , , , cord-015021-pol2qm74 7020 14 the the DT cord-015021-pol2qm74 7020 15 following follow VBG cord-015021-pol2qm74 7020 16 parameters parameter NNS cord-015021-pol2qm74 7020 17 were be VBD cord-015021-pol2qm74 7020 18 assessed assess VBN cord-015021-pol2qm74 7020 19 : : : cord-015021-pol2qm74 7020 20 serum serum NN cord-015021-pol2qm74 7020 21 level level NN cord-015021-pol2qm74 7020 22 of of IN cord-015021-pol2qm74 7020 23 transferrin transferrin NN cord-015021-pol2qm74 7020 24 , , , cord-015021-pol2qm74 7020 25 albumin albumin NN cord-015021-pol2qm74 7020 26 , , , cord-015021-pol2qm74 7020 27 prealbumin prealbumin NNP cord-015021-pol2qm74 7020 28 , , , cord-015021-pol2qm74 7020 29 retiool retiool NN cord-015021-pol2qm74 7020 30 binding bind VBG cord-015021-pol2qm74 7020 31 protein protein NN cord-015021-pol2qm74 7020 32 ( ( -LRB- cord-015021-pol2qm74 7020 33 RBP RBP NNP cord-015021-pol2qm74 7020 34 ) ) -RRB- cord-015021-pol2qm74 7020 35 , , , cord-015021-pol2qm74 7020 36 cholinesterase cholinesterase NN cord-015021-pol2qm74 7020 37 . . . cord-015021-pol2qm74 7021 1 Delayed delayed JJ cord-015021-pol2qm74 7021 2 hypersensitivity hypersensitivity NN cord-015021-pol2qm74 7021 3 response response NN cord-015021-pol2qm74 7021 4 , , , cord-015021-pol2qm74 7021 5 IgG IgG NNP cord-015021-pol2qm74 7021 6 , , , cord-015021-pol2qm74 7021 7 IgM IgM NNP cord-015021-pol2qm74 7021 8 , , , cord-015021-pol2qm74 7021 9 IgA IgA NNP cord-015021-pol2qm74 7021 10 , , , cord-015021-pol2qm74 7021 11 lymphocyte lymphocyte NN cord-015021-pol2qm74 7021 12 subsets subset NNS cord-015021-pol2qm74 7021 13 and and CC cord-015021-pol2qm74 7021 14 monocyte monocyte JJ cord-015021-pol2qm74 7021 15 phagocytosis phagocytosis NN cord-015021-pol2qm74 7021 16 ability ability NN cord-015021-pol2qm74 7021 17 were be VBD cord-015021-pol2qm74 7021 18 evaluated evaluate VBN cord-015021-pol2qm74 7021 19 on on IN cord-015021-pol2qm74 7021 20 admission admission NN cord-015021-pol2qm74 7021 21 and and CC cord-015021-pol2qm74 7021 22 on on IN cord-015021-pol2qm74 7021 23 post post JJ cord-015021-pol2qm74 7021 24 - - JJ cord-015021-pol2qm74 7021 25 operative operative JJ cord-015021-pol2qm74 7021 26 day day NN cord-015021-pol2qm74 7021 27 1 1 CD cord-015021-pol2qm74 7021 28 , , , cord-015021-pol2qm74 7021 29 4 4 CD cord-015021-pol2qm74 7021 30 , , , cord-015021-pol2qm74 7021 31 8 8 CD cord-015021-pol2qm74 7021 32 . . . cord-015021-pol2qm74 7022 1 The the DT cord-015021-pol2qm74 7022 2 three three CD cord-015021-pol2qm74 7022 3 groups group NNS cord-015021-pol2qm74 7022 4 were be VBD cord-015021-pol2qm74 7022 5 comparable comparable JJ cord-015021-pol2qm74 7022 6 for for IN cord-015021-pol2qm74 7022 7 sex sex NN cord-015021-pol2qm74 7022 8 , , , cord-015021-pol2qm74 7022 9 age age NN cord-015021-pol2qm74 7022 10 , , , cord-015021-pol2qm74 7022 11 cancer cancer NN cord-015021-pol2qm74 7022 12 stage stage NN cord-015021-pol2qm74 7022 13 , , , cord-015021-pol2qm74 7022 14 type type NN cord-015021-pol2qm74 7022 15 and and CC cord-015021-pol2qm74 7022 16 duration duration NN cord-015021-pol2qm74 7022 17 of of IN cord-015021-pol2qm74 7022 18 surgery surgery NN cord-015021-pol2qm74 7022 19 , , , cord-015021-pol2qm74 7022 20 intra intra JJ cord-015021-pol2qm74 7022 21 - - JJ cord-015021-pol2qm74 7022 22 operative operative JJ cord-015021-pol2qm74 7022 23 blood blood NN cord-015021-pol2qm74 7022 24 loss loss NN cord-015021-pol2qm74 7022 25 and and CC cord-015021-pol2qm74 7022 26 amount amount NN cord-015021-pol2qm74 7022 27 of of IN cord-015021-pol2qm74 7022 28 blood blood NN cord-015021-pol2qm74 7022 29 transfused transfuse VBN cord-015021-pol2qm74 7022 30 . . . cord-015021-pol2qm74 7023 1 In in IN cord-015021-pol2qm74 7023 2 all all DT cord-015021-pol2qm74 7023 3 groups group NNS cord-015021-pol2qm74 7023 4 a a DT cord-015021-pol2qm74 7023 5 significant significant JJ cord-015021-pol2qm74 7023 6 drop drop NN cord-015021-pol2qm74 7023 7 in in IN cord-015021-pol2qm74 7023 8 all all PDT cord-015021-pol2qm74 7023 9 the the DT cord-015021-pol2qm74 7023 10 nutritional nutritional JJ cord-015021-pol2qm74 7023 11 and and CC cord-015021-pol2qm74 7023 12 immunological immunological JJ cord-015021-pol2qm74 7023 13 parameters parameter NNS cord-015021-pol2qm74 7023 14 was be VBD cord-015021-pol2qm74 7023 15 observed observe VBN cord-015021-pol2qm74 7023 16 on on IN cord-015021-pol2qm74 7023 17 postoperative postoperative JJ cord-015021-pol2qm74 7023 18 day day NN cord-015021-pol2qm74 7023 19 1 1 CD cord-015021-pol2qm74 7023 20 . . . cord-015021-pol2qm74 7024 1 Comparing compare VBG cord-015021-pol2qm74 7024 2 post post JJ cord-015021-pol2qm74 7024 3 - - JJ cord-015021-pol2qm74 7024 4 operative operative JJ cord-015021-pol2qm74 7024 5 day day NN cord-015021-pol2qm74 7024 6 1 1 CD cord-015021-pol2qm74 7024 7 versus versus IN cord-015021-pol2qm74 7024 8 day day NN cord-015021-pol2qm74 7024 9 8 8 CD cord-015021-pol2qm74 7024 10 a a DT cord-015021-pol2qm74 7024 11 significant significant JJ cord-015021-pol2qm74 7024 12 increase increase NN cord-015021-pol2qm74 7024 13 of of IN cord-015021-pol2qm74 7024 14 prealbumin prealbumin NN cord-015021-pol2qm74 7024 15 ( ( -LRB- cord-015021-pol2qm74 7024 16 p<0.02 p<0.02 NN cord-015021-pol2qm74 7024 17 ) ) -RRB- cord-015021-pol2qm74 7024 18 and and CC cord-015021-pol2qm74 7024 19 RBP RBP NNP cord-015021-pol2qm74 7024 20 ( ( -LRB- cord-015021-pol2qm74 7024 21 p<0.005 p<0.005 JJ cord-015021-pol2qm74 7024 22 ) ) -RRB- cord-015021-pol2qm74 7024 23 was be VBD cord-015021-pol2qm74 7024 24 found find VBN cord-015021-pol2qm74 7024 25 only only RB cord-015021-pol2qm74 7024 26 in in IN cord-015021-pol2qm74 7024 27 the the DT cord-015021-pol2qm74 7024 28 enriched enriched JJ cord-015021-pol2qm74 7024 29 group group NN cord-015021-pol2qm74 7024 30 . . . cord-015021-pol2qm74 7025 1 With with IN cord-015021-pol2qm74 7025 2 respect respect NN cord-015021-pol2qm74 7025 3 to to IN cord-015021-pol2qm74 7025 4 immunological immunological JJ cord-015021-pol2qm74 7025 5 variables variable NNS cord-015021-pol2qm74 7025 6 an an DT cord-015021-pol2qm74 7025 7 increased increase VBN cord-015021-pol2qm74 7025 8 phagocytosis phagocytosis NN cord-015021-pol2qm74 7025 9 ability ability NN cord-015021-pol2qm74 7025 10 ( ( -LRB- cord-015021-pol2qm74 7025 11 p<0.001 p<0.001 CD cord-015021-pol2qm74 7025 12 ) ) -RRB- cord-015021-pol2qm74 7025 13 and and CC cord-015021-pol2qm74 7025 14 a a DT cord-015021-pol2qm74 7025 15 significant significant JJ cord-015021-pol2qm74 7025 16 recovery recovery NN cord-015021-pol2qm74 7025 17 in in IN cord-015021-pol2qm74 7025 18 delayed delay VBN cord-015021-pol2qm74 7025 19 hypersensitivity hypersensitivity NN cord-015021-pol2qm74 7025 20 response response NN cord-015021-pol2qm74 7025 21 ( ( -LRB- cord-015021-pol2qm74 7025 22 p p NN cord-015021-pol2qm74 7025 23 < < XX cord-015021-pol2qm74 7025 24 0.005 0.005 CD cord-015021-pol2qm74 7025 25 ) ) -RRB- cord-015021-pol2qm74 7025 26 was be VBD cord-015021-pol2qm74 7025 27 observed observe VBN cord-015021-pol2qm74 7025 28 only only RB cord-015021-pol2qm74 7025 29 in in IN cord-015021-pol2qm74 7025 30 the the DT cord-015021-pol2qm74 7025 31 enriched enriched JJ cord-015021-pol2qm74 7025 32 group group NN cord-015021-pol2qm74 7025 33 . . . cord-015021-pol2qm74 7026 1 Conclusions conclusion NNS cord-015021-pol2qm74 7026 2 : : : cord-015021-pol2qm74 7027 1 These these DT cord-015021-pol2qm74 7027 2 data datum NNS cord-015021-pol2qm74 7027 3 are be VBP cord-015021-pol2qm74 7027 4 suggestive suggestive JJ cord-015021-pol2qm74 7027 5 for for IN cord-015021-pol2qm74 7027 6 a a DT cord-015021-pol2qm74 7027 7 more more RBR cord-015021-pol2qm74 7027 8 effective effective JJ cord-015021-pol2qm74 7027 9 post post JJ cord-015021-pol2qm74 7027 10 - - JJ cord-015021-pol2qm74 7027 11 operative operative JJ cord-015021-pol2qm74 7027 12 recovery recovery NN cord-015021-pol2qm74 7027 13 of of IN cord-015021-pol2qm74 7027 14 both both DT cord-015021-pol2qm74 7027 15 . . . cord-015021-pol2qm74 7028 1 nutritional nutritional JJ cord-015021-pol2qm74 7028 2 and and CC cord-015021-pol2qm74 7028 3 immunological immunological JJ cord-015021-pol2qm74 7028 4 status status NN cord-015021-pol2qm74 7028 5 in in IN cord-015021-pol2qm74 7028 6 cancer cancer NN cord-015021-pol2qm74 7028 7 patients patient NNS cord-015021-pol2qm74 7028 8 fed feed VBN cord-015021-pol2qm74 7028 9 with with IN cord-015021-pol2qm74 7028 10 enriched enriched JJ cord-015021-pol2qm74 7028 11 enteral enteral NN cord-015021-pol2qm74 7028 12 formula formula NN cord-015021-pol2qm74 7028 13 . . . cord-015021-pol2qm74 7029 1 Gastrointestinal gastrointestinal JJ cord-015021-pol2qm74 7029 2 intolerance intolerance NN cord-015021-pol2qm74 7029 3 was be VBD cord-015021-pol2qm74 7029 4 equivalent equivalent JJ cord-015021-pol2qm74 7029 5 ( ( -LRB- cord-015021-pol2qm74 7029 6 18 18 CD cord-015021-pol2qm74 7029 7 % % NN cord-015021-pol2qm74 7029 8 in in IN cord-015021-pol2qm74 7029 9 each each DT cord-015021-pol2qm74 7029 10 group group NN cord-015021-pol2qm74 7029 11 ) ) -RRB- cord-015021-pol2qm74 7029 12 and and CC cord-015021-pol2qm74 7029 13 laboratory laboratory NN cord-015021-pol2qm74 7029 14 screening screening NN cord-015021-pol2qm74 7029 15 confirmed confirm VBD cord-015021-pol2qm74 7029 16 that that IN cord-015021-pol2qm74 7029 17 both both DT cord-015021-pol2qm74 7029 18 diets diet NNS cord-015021-pol2qm74 7029 19 were be VBD cord-015021-pol2qm74 7029 20 safe safe JJ cord-015021-pol2qm74 7029 21 . . . cord-015021-pol2qm74 7030 1 When when WRB cord-015021-pol2qm74 7030 2 analyzing analyze VBG cord-015021-pol2qm74 7030 3 clinical clinical JJ cord-015021-pol2qm74 7030 4 outcome outcome NN cord-015021-pol2qm74 7030 5 for for IN cord-015021-pol2qm74 7030 6 all all DT cord-015021-pol2qm74 7030 7 patients patient NNS cord-015021-pol2qm74 7030 8 , , , cord-015021-pol2qm74 7030 9 there there EX cord-015021-pol2qm74 7030 10 were be VBD cord-015021-pol2qm74 7030 11 no no DT cord-015021-pol2qm74 7030 12 significant significant JJ cord-015021-pol2qm74 7030 13 differences difference NNS cord-015021-pol2qm74 7030 14 in in IN cord-015021-pol2qm74 7030 15 septic septic JJ cord-015021-pol2qm74 7030 16 complications complication NNS cord-015021-pol2qm74 7030 17 ( ( -LRB- cord-015021-pol2qm74 7030 18 Immun Immun NNP cord-015021-pol2qm74 7030 19 - - HYPH cord-015021-pol2qm74 7030 20 Aid Aid NNP cord-015021-pol2qm74 7030 21 = = SYM cord-015021-pol2qm74 7030 22 41 41 CD cord-015021-pol2qm74 7030 23 % % NN cord-015021-pol2qm74 7030 24 vs vs IN cord-015021-pol2qm74 7030 25 Vivonex Vivonex NNP cord-015021-pol2qm74 7030 26 TEN TEN NNP cord-015021-pol2qm74 7030 27 = = SYM cord-015021-pol2qm74 7030 28 35 35 CD cord-015021-pol2qm74 7030 29 % % NN cord-015021-pol2qm74 7030 30 ) ) -RRB- cord-015021-pol2qm74 7030 31 , , , cord-015021-pol2qm74 7030 32 mean mean VB cord-015021-pol2qm74 7030 33 MOF MOF NNP cord-015021-pol2qm74 7030 34 score score NN cord-015021-pol2qm74 7030 35 ( ( -LRB- cord-015021-pol2qm74 7030 36 Immun Immun NNP cord-015021-pol2qm74 7030 37 - - HYPH cord-015021-pol2qm74 7030 38 Aid aid NN cord-015021-pol2qm74 7030 39 = = NFP cord-015021-pol2qm74 7031 1 l. l. NNP cord-015021-pol2qm74 7032 1 B B NNP cord-015021-pol2qm74 7032 2 vs vs IN cord-015021-pol2qm74 7032 3 Vivonex Vivonex NNP cord-015021-pol2qm74 7032 4 TEN TEN NNP cord-015021-pol2qm74 7032 5 = = SYM cord-015021-pol2qm74 7032 6 3.6 3.6 CD cord-015021-pol2qm74 7032 7 ) ) -RRB- cord-015021-pol2qm74 7032 8 , , , cord-015021-pol2qm74 7032 9 or or CC cord-015021-pol2qm74 7032 10 mortality mortality NN cord-015021-pol2qm74 7033 1 ( ( -LRB- cord-015021-pol2qm74 7033 2 Immun Immun NNP cord-015021-pol2qm74 7033 3 - - HYPH cord-015021-pol2qm74 7033 4 Aid aid NN cord-015021-pol2qm74 7033 5 0 0 CD cord-015021-pol2qm74 7033 6 % % NN cord-015021-pol2qm74 7033 7 vs vs IN cord-015021-pol2qm74 7033 8 Vivonex Vivonex NNP cord-015021-pol2qm74 7033 9 TEN TEN NNP cord-015021-pol2qm74 7033 10 = = SYM cord-015021-pol2qm74 7033 11 6 6 CD cord-015021-pol2qm74 7033 12 % % NN cord-015021-pol2qm74 7033 13 ) ) -RRB- cord-015021-pol2qm74 7033 14 . . . cord-015021-pol2qm74 7034 1 Kowever Kowever NNP cord-015021-pol2qm74 7034 2 , , , cord-015021-pol2qm74 7034 3 when when WRB cord-015021-pol2qm74 7034 4 analyzing analyze VBG cord-015021-pol2qm74 7034 5 the the DT cord-015021-pol2qm74 7034 6 subgroup subgroup NN cord-015021-pol2qm74 7034 7 of of IN cord-015021-pol2qm74 7034 8 patients patient NNS cord-015021-pol2qm74 7034 9 with with IN cord-015021-pol2qm74 7034 10 severe severe JJ cord-015021-pol2qm74 7034 11 injury injury NN cord-015021-pol2qm74 7034 12 ( ( -LRB- cord-015021-pol2qm74 7034 13 ISS ISS NNP cord-015021-pol2qm74 7034 14 or or CC cord-015021-pol2qm74 7035 1 ATI ATI NNP cord-015021-pol2qm74 7035 2 _ _ NNP cord-015021-pol2qm74 7036 1 > > XX cord-015021-pol2qm74 7036 2 25 25 CD cord-015021-pol2qm74 7036 3 ) ) -RRB- cord-015021-pol2qm74 7036 4 , , , cord-015021-pol2qm74 7036 5 patients patient NNS cord-015021-pol2qm74 7036 6 receiving receive VBG cord-015021-pol2qm74 7036 7 Immun Immun NNP cord-015021-pol2qm74 7036 8 - - HYPH cord-015021-pol2qm74 7036 9 Aid Aid NNP cord-015021-pol2qm74 7036 10 appeared appear VBD cord-015021-pol2qm74 7036 11 to to TO cord-015021-pol2qm74 7036 12 have have VB cord-015021-pol2qm74 7036 13 fewer few JJR cord-015021-pol2qm74 7036 14 septic septic JJ cord-015021-pol2qm74 7036 15 complications complication NNS cord-015021-pol2qm74 7036 16 ( ( -LRB- cord-015021-pol2qm74 7036 17 33 33 CD cord-015021-pol2qm74 7036 18 % % NN cord-015021-pol2qm74 7036 19 vs vs IN cord-015021-pol2qm74 7036 20 50 50 CD cord-015021-pol2qm74 7036 21 % % NN cord-015021-pol2qm74 7036 22 ) ) -RRB- cord-015021-pol2qm74 7036 23 and and CC cord-015021-pol2qm74 7036 24 their -PRON- PRP$ cord-015021-pol2qm74 7036 25 mean mean JJ cord-015021-pol2qm74 7036 26 MOF MOF NNP cord-015021-pol2qm74 7036 27 was be VBD cord-015021-pol2qm74 7036 28 significantly significantly RB cord-015021-pol2qm74 7036 29 lower low JJR cord-015021-pol2qm74 7036 30 ( ( -LRB- cord-015021-pol2qm74 7037 1 1.8 1.8 CD cord-015021-pol2qm74 7037 2 _ _ NN cord-015021-pol2qm74 7037 3 + + CC cord-015021-pol2qm74 7038 1 0.7 0.7 CD cord-015021-pol2qm74 7038 2 vs vs IN cord-015021-pol2qm74 7038 3 5.8 5.8 CD cord-015021-pol2qm74 7038 4 + + SYM cord-015021-pol2qm74 7038 5 1.7 1.7 CD cord-015021-pol2qm74 7038 6 , , , cord-015021-pol2qm74 7038 7 p p NN cord-015021-pol2qm74 7038 8 = = SYM cord-015021-pol2qm74 7038 9 0.05 0.05 CD cord-015021-pol2qm74 7038 10 , , , cord-015021-pol2qm74 7038 11 Student Student NNP cord-015021-pol2qm74 7038 12 's 's POS cord-015021-pol2qm74 7038 13 t t NN cord-015021-pol2qm74 7038 14 - - HYPH cord-015021-pol2qm74 7038 15 test test NN cord-015021-pol2qm74 7038 16 ) ) -RRB- cord-015021-pol2qm74 7038 17 . . . cord-015021-pol2qm74 7039 1 These these DT cord-015021-pol2qm74 7039 2 preliminary preliminary JJ cord-015021-pol2qm74 7039 3 data datum NNS cord-015021-pol2qm74 7039 4 indicate indicate VBP cord-015021-pol2qm74 7039 5 that that IN cord-015021-pol2qm74 7039 6 Immun Immun NNP cord-015021-pol2qm74 7039 7 - - HYPH cord-015021-pol2qm74 7039 8 Aid Aid NNP cord-015021-pol2qm74 7039 9 is be VBZ cord-015021-pol2qm74 7039 10 tolerated tolerate VBN cord-015021-pol2qm74 7039 11 well well RB cord-015021-pol2qm74 7039 12 when when WRB cord-015021-pol2qm74 7039 13 aggressively aggressively RB cord-015021-pol2qm74 7039 14 delivered deliver VBN cord-015021-pol2qm74 7039 15 immediately immediately RB cord-015021-pol2qm74 7039 16 postinjury postinjury NNP cord-015021-pol2qm74 7039 17 . . . cord-015021-pol2qm74 7040 1 The the DT cord-015021-pol2qm74 7040 2 ultimate ultimate JJ cord-015021-pol2qm74 7040 3 affect affect NN cord-015021-pol2qm74 7040 4 on on IN cord-015021-pol2qm74 7040 5 clinical clinical JJ cord-015021-pol2qm74 7040 6 outcome outcome NN cord-015021-pol2qm74 7040 7 appears appear VBZ cord-015021-pol2qm74 7040 8 ~avorable ~avorable NNP cord-015021-pol2qm74 7040 9 for for IN cord-015021-pol2qm74 7040 10 Immun Immun NNP cord-015021-pol2qm74 7040 11 - - HYPH cord-015021-pol2qm74 7040 12 Aid Aid NNP cord-015021-pol2qm74 7040 13 , , , cord-015021-pol2qm74 7040 14 but but CC cord-015021-pol2qm74 7040 15 needs need VBZ cord-015021-pol2qm74 7040 16 to to TO cord-015021-pol2qm74 7040 17 be be VB cord-015021-pol2qm74 7040 18 confirmed confirm VBN cord-015021-pol2qm74 7040 19 in in IN cord-015021-pol2qm74 7040 20 larger large JJR cord-015021-pol2qm74 7040 21 patient patient NN cord-015021-pol2qm74 7040 22 groups group NNS cord-015021-pol2qm74 7040 23 . . . cord-015021-pol2qm74 7041 1 Kemp?n Kemp?n NNP cord-015021-pol2qm74 7041 2 , , , cord-015021-pol2qm74 7041 3 M. M. NNP cord-015021-pol2qm74 7041 4 , , , cord-015021-pol2qm74 7041 5 Neumann Neumann NNP cord-015021-pol2qm74 7041 6 , , , cord-015021-pol2qm74 7041 7 H.A. H.A. NNP cord-015021-pol2qm74 7041 8 , , , cord-015021-pol2qm74 7042 1 He -PRON- PRP cord-015021-pol2qm74 7042 2 I[michh i[michh NN cord-015021-pol2qm74 7042 3 B b NN cord-015021-pol2qm74 7042 4 : : : cord-015021-pol2qm74 7042 5 As as IN cord-015021-pol2qm74 7042 6 both both DT cord-015021-pol2qm74 7042 7 increased increase VBN cord-015021-pol2qm74 7042 8 , , , cord-015021-pol2qm74 7042 9 normal normal JJ cord-015021-pol2qm74 7042 10 and and CC cord-015021-pol2qm74 7042 11 reduced reduced JJ cord-015021-pol2qm74 7042 12 phagocytic phagocytic JJ cord-015021-pol2qm74 7042 13 capabilities capability NNS cord-015021-pol2qm74 7042 14 of of IN cord-015021-pol2qm74 7042 15 polymorphonuclear polymorphonuclear JJ cord-015021-pol2qm74 7042 16 leukocytes leukocyte NNS cord-015021-pol2qm74 7042 17 ( ( -LRB- cord-015021-pol2qm74 7042 18 PMN PMN NNP cord-015021-pol2qm74 7042 19 ) ) -RRB- cord-015021-pol2qm74 7042 20 and and CC cord-015021-pol2qm74 7042 21 monocytes monocyte VBZ cord-015021-pol2qm74 7042 22 in in IN cord-015021-pol2qm74 7042 23 acute acute JJ cord-015021-pol2qm74 7042 24 batterial batterial JJ cord-015021-pol2qm74 7042 25 infections infection NNS cord-015021-pol2qm74 7042 26 have have VBP cord-015021-pol2qm74 7042 27 been be VBN cord-015021-pol2qm74 7042 28 reported report VBN cord-015021-pol2qm74 7042 29 , , , cord-015021-pol2qm74 7042 30 the the DT cord-015021-pol2qm74 7042 31 role role NN cord-015021-pol2qm74 7042 32 of of IN cord-015021-pol2qm74 7042 33 phagocytes phagocyte NNS cord-015021-pol2qm74 7042 34 in in IN cord-015021-pol2qm74 7042 35 patients patient NNS cord-015021-pol2qm74 7042 36 with with IN cord-015021-pol2qm74 7042 37 severe severe JJ cord-015021-pol2qm74 7042 38 sepsis sepsis NN cord-015021-pol2qm74 7042 39 is be VBZ cord-015021-pol2qm74 7042 40 less less RBR cord-015021-pol2qm74 7042 41 clear clear JJ cord-015021-pol2qm74 7042 42 . . . cord-015021-pol2qm74 7043 1 We -PRON- PRP cord-015021-pol2qm74 7043 2 examined examine VBD cord-015021-pol2qm74 7043 3 PMN PMN NNP cord-015021-pol2qm74 7043 4 and and CC cord-015021-pol2qm74 7043 5 monocytes monocyte VBZ cord-015021-pol2qm74 7043 6 from from IN cord-015021-pol2qm74 7043 7 10 10 CD cord-015021-pol2qm74 7043 8 patients patient NNS cord-015021-pol2qm74 7043 9 in in IN cord-015021-pol2qm74 7043 10 septic septic JJ cord-015021-pol2qm74 7043 11 shock shock NN cord-015021-pol2qm74 7043 12 and and CC cord-015021-pol2qm74 7043 13 17 17 CD cord-015021-pol2qm74 7043 14 heaiLhy heaiLhy NNP cord-015021-pol2qm74 7043 15 votunteers votunteer NNS cord-015021-pol2qm74 7043 16 for for IN cord-015021-pol2qm74 7043 17 phagocytic phagocytic JJ cord-015021-pol2qm74 7043 18 function function NN cord-015021-pol2qm74 7043 19 . . . cord-015021-pol2qm74 7044 1 Phagocytosis Phagocytosis NNP cord-015021-pol2qm74 7044 2 was be VBD cord-015021-pol2qm74 7044 3 determined determine VBN cord-015021-pol2qm74 7044 4 by by IN cord-015021-pol2qm74 7044 5 flow flow NN cord-015021-pol2qm74 7044 6 cytometry cytometry NN cord-015021-pol2qm74 7044 7 ( ( -LRB- cord-015021-pol2qm74 7044 8 FACScan FACScan NNP cord-015021-pol2qm74 7044 9 ) ) -RRB- cord-015021-pol2qm74 7044 10 and and CC cord-015021-pol2qm74 7044 11 was be VBD cord-015021-pol2qm74 7044 12 measured measure VBN cord-015021-pol2qm74 7044 13 by by IN cord-015021-pol2qm74 7044 14 the the DT cord-015021-pol2qm74 7044 15 ability ability NN cord-015021-pol2qm74 7044 16 of of IN cord-015021-pol2qm74 7044 17 PMN PMN NNP cord-015021-pol2qm74 7044 18 and and CC cord-015021-pol2qm74 7044 19 monocytes monocyte VBZ cord-015021-pol2qm74 7044 20 to to TO cord-015021-pol2qm74 7044 21 phagocytose phagocytose JJ cord-015021-pol2qm74 7044 22 E.Coli E.Coli NNS cord-015021-pol2qm74 7044 23 marked mark VBN cord-015021-pol2qm74 7044 24 with with IN cord-015021-pol2qm74 7044 25 fluorescent fluorescent JJ cord-015021-pol2qm74 7044 26 antibodies antibody NNS cord-015021-pol2qm74 7044 27 . . . cord-015021-pol2qm74 7045 1 A a DT cord-015021-pol2qm74 7045 2 septic septic JJ cord-015021-pol2qm74 7045 3 shock shock NN cord-015021-pol2qm74 7045 4 was be VBD cord-015021-pol2qm74 7045 5 defined define VBN cord-015021-pol2qm74 7045 6 by by IN cord-015021-pol2qm74 7045 7 the the DT cord-015021-pol2qm74 7045 8 presence presence NN cord-015021-pol2qm74 7045 9 of of IN cord-015021-pol2qm74 7045 10 a a DT cord-015021-pol2qm74 7045 11 ~ource ~ource NNP cord-015021-pol2qm74 7045 12 of of IN cord-015021-pol2qm74 7045 13 i i NNP cord-015021-pol2qm74 7045 14 , , , cord-015021-pol2qm74 7045 15 nfoctiQn nfoctiQn NNP cord-015021-pol2qm74 7045 16 with with IN cord-015021-pol2qm74 7045 17 a a DT cord-015021-pol2qm74 7045 18 known know VBN cord-015021-pol2qm74 7045 19 bacteriology bacteriology NN cord-015021-pol2qm74 7045 20 , , , cord-015021-pol2qm74 7045 21 distinct distinct JJ cord-015021-pol2qm74 7045 22 signs sign NNS cord-015021-pol2qm74 7045 23 of of IN cord-015021-pol2qm74 7045 24 a a DT cord-015021-pol2qm74 7045 25 systemic systemic JJ cord-015021-pol2qm74 7045 26 response response NN cord-015021-pol2qm74 7045 27 and and CC cord-015021-pol2qm74 7045 28 defined define VBN cord-015021-pol2qm74 7045 29 minimum minimum JJ cord-015021-pol2qm74 7045 30 scores score NNS cord-015021-pol2qm74 7045 31 in in IN cord-015021-pol2qm74 7045 32 3 3 CD cord-015021-pol2qm74 7045 33 ICU ICU NNP cord-015021-pol2qm74 7045 34 scoring score VBG cord-015021-pol2qm74 7045 35 systems system NNS cord-015021-pol2qm74 7045 36 indicating indicate VBG cord-015021-pol2qm74 7045 37 the the DT cord-015021-pol2qm74 7045 38 presence presence NN cord-015021-pol2qm74 7045 39 of of IN cord-015021-pol2qm74 7045 40 a a DT cord-015021-pol2qm74 7045 41 multiple multiple JJ cord-015021-pol2qm74 7045 42 organ organ NN cord-015021-pol2qm74 7045 43 failure failure NN cord-015021-pol2qm74 7045 44 . . . cord-015021-pol2qm74 7046 1 Additionally additionally RB cord-015021-pol2qm74 7046 2 we -PRON- PRP cord-015021-pol2qm74 7046 3 examined examine VBD cord-015021-pol2qm74 7046 4 how how WRB cord-015021-pol2qm74 7046 5 phagocytosis phagocytosis NN cord-015021-pol2qm74 7046 6 is be VBZ cord-015021-pol2qm74 7046 7 influenced influence VBN cord-015021-pol2qm74 7046 8 when when WRB cord-015021-pol2qm74 7046 9 a a DT cord-015021-pol2qm74 7046 10 new new JJ cord-015021-pol2qm74 7046 11 enteral enteral JJ cord-015021-pol2qm74 7046 12 diet diet NN cord-015021-pol2qm74 7046 13 formulation formulation NN cord-015021-pol2qm74 7046 14 containing contain VBG cord-015021-pol2qm74 7046 15 substrates substrate NNS cord-015021-pol2qm74 7046 16 suggested suggest VBD cord-015021-pol2qm74 7046 17 to to TO cord-015021-pol2qm74 7046 18 improve improve VB cord-015021-pol2qm74 7046 19 immune immune JJ cord-015021-pol2qm74 7046 20 function function NN cord-015021-pol2qm74 7046 21 or or CC cord-015021-pol2qm74 7046 22 Arginine arginine NN cord-015021-pol2qm74 7046 23 , , , cord-015021-pol2qm74 7046 24 one one CD cord-015021-pol2qm74 7046 25 of of IN cord-015021-pol2qm74 7046 26 its -PRON- PRP$ cord-015021-pol2qm74 7046 27 major major JJ cord-015021-pol2qm74 7046 28 compononts componont NNS cord-015021-pol2qm74 7046 29 , , , cord-015021-pol2qm74 7046 30 is be VBZ cord-015021-pol2qm74 7046 31 added add VBN cord-015021-pol2qm74 7046 32 in in IN cord-015021-pol2qm74 7046 33 vitro vitro FW cord-015021-pol2qm74 7046 34 in in IN cord-015021-pol2qm74 7046 35 defined define VBN cord-015021-pol2qm74 7046 36 concentrations concentration NNS cord-015021-pol2qm74 7046 37 and and CC cord-015021-pol2qm74 7046 38 incubated incubate VBN cord-015021-pol2qm74 7046 39 for for IN cord-015021-pol2qm74 7046 40 10 10 CD cord-015021-pol2qm74 7046 41 minutes minute NNS cord-015021-pol2qm74 7046 42 . . . cord-015021-pol2qm74 7047 1 PMN PMN NNP cord-015021-pol2qm74 7047 2 ( ( -LRB- cord-015021-pol2qm74 7047 3 p{O,05 p{O,05 NNP cord-015021-pol2qm74 7047 4 ) ) -RRB- cord-015021-pol2qm74 7047 5 and and CC cord-015021-pol2qm74 7047 6 monocytes monocyte NNS cord-015021-pol2qm74 7047 7 ( ( -LRB- cord-015021-pol2qm74 7047 8 p p NN cord-015021-pol2qm74 7047 9 < < XX cord-015021-pol2qm74 7047 10 O,01 O,01 NNP cord-015021-pol2qm74 7047 11 ) ) -RRB- cord-015021-pol2qm74 7047 12 of of IN cord-015021-pol2qm74 7047 13 the the DT cord-015021-pol2qm74 7047 14 septic septic JJ cord-015021-pol2qm74 7047 15 patients patient NNS cord-015021-pol2qm74 7047 16 showed show VBD cord-015021-pol2qm74 7047 17 a a DT cord-015021-pol2qm74 7047 18 significantly significantly RB cord-015021-pol2qm74 7047 19 enhanced enhance VBN cord-015021-pol2qm74 7047 20 phagocytosis phagocytosis NN cord-015021-pol2qm74 7047 21 compared compare VBN cord-015021-pol2qm74 7047 22 toLhe tolhe NN cord-015021-pol2qm74 7047 23 phagocytes phagocyte NNS cord-015021-pol2qm74 7047 24 of of IN cord-015021-pol2qm74 7047 25 the the DT cord-015021-pol2qm74 7047 26 healthy healthy JJ cord-015021-pol2qm74 7047 27 group group NN cord-015021-pol2qm74 7047 28 . . . cord-015021-pol2qm74 7048 1 The the DT cord-015021-pol2qm74 7048 2 incubation incubation NN cord-015021-pol2qm74 7048 3 with with IN cord-015021-pol2qm74 7048 4 the the DT cord-015021-pol2qm74 7048 5 enteral enteral JJ cord-015021-pol2qm74 7048 6 diet diet NN cord-015021-pol2qm74 7048 7 in in IN cord-015021-pol2qm74 7048 8 vitro vitro FW cord-015021-pol2qm74 7048 9 was be VBD cord-015021-pol2qm74 7048 10 followed follow VBN cord-015021-pol2qm74 7048 11 by by IN cord-015021-pol2qm74 7048 12 a a DT cord-015021-pol2qm74 7048 13 higher high JJR cord-015021-pol2qm74 7048 14 dose dose NN cord-015021-pol2qm74 7048 15 - - HYPH cord-015021-pol2qm74 7048 16 related relate VBN cord-015021-pol2qm74 7048 17 rate rate NN cord-015021-pol2qm74 7048 18 of of IN cord-015021-pol2qm74 7048 19 phagocytosis phagocytosis NN cord-015021-pol2qm74 7048 20 , , , cord-015021-pol2qm74 7048 21 especially especially RB cord-015021-pol2qm74 7048 22 in in IN cord-015021-pol2qm74 7048 23 the the DT cord-015021-pol2qm74 7048 24 healthy healthy JJ cord-015021-pol2qm74 7048 25 group group NN cord-015021-pol2qm74 7048 26 , , , cord-015021-pol2qm74 7048 27 that that WDT cord-015021-pol2qm74 7048 28 was be VBD cord-015021-pol2qm74 7048 29 not not RB cord-015021-pol2qm74 7048 30 statistically statistically RB cord-015021-pol2qm74 7048 31 significant significant JJ cord-015021-pol2qm74 7048 32 . . . cord-015021-pol2qm74 7049 1 After after IN cord-015021-pol2qm74 7049 2 addition addition NN cord-015021-pol2qm74 7049 3 of of IN cord-015021-pol2qm74 7049 4 L L NNP cord-015021-pol2qm74 7049 5 - - HYPH cord-015021-pol2qm74 7049 6 Argintne Argintne NNP cord-015021-pol2qm74 7049 7 we -PRON- PRP cord-015021-pol2qm74 7049 8 atso atso RB cord-015021-pol2qm74 7049 9 observed observe VBD cord-015021-pol2qm74 7049 10 an an DT cord-015021-pol2qm74 7049 11 iqcrease iqcrease NN cord-015021-pol2qm74 7049 12 in in IN cord-015021-pol2qm74 7049 13 phagocytosis phagocytosis NN cord-015021-pol2qm74 7049 14 , , , cord-015021-pol2qm74 7049 15 that that WDT cord-015021-pol2qm74 7049 16 was be VBD cord-015021-pol2qm74 7049 17 lower low JJR cord-015021-pol2qm74 7049 18 than than IN cord-015021-pol2qm74 7049 19 in in IN cord-015021-pol2qm74 7049 20 the the DT cord-015021-pol2qm74 7049 21 group group NN cord-015021-pol2qm74 7049 22 with with IN cord-015021-pol2qm74 7049 23 the the DT cord-015021-pol2qm74 7049 24 complete complete JJ cord-015021-pol2qm74 7049 25 diet diet NN cord-015021-pol2qm74 7049 26 . . . cord-015021-pol2qm74 7050 1 Using use VBG cord-015021-pol2qm74 7050 2 a a DT cord-015021-pol2qm74 7050 3 modern modern JJ cord-015021-pol2qm74 7050 4 immunefluorescence immunefluorescence NN cord-015021-pol2qm74 7050 5 - - HYPH cord-015021-pol2qm74 7050 6 cytometric cytometric NN cord-015021-pol2qm74 7050 7 essay essay NN cord-015021-pol2qm74 7050 8 we -PRON- PRP cord-015021-pol2qm74 7050 9 founfl founfl VBP cord-015021-pol2qm74 7050 10 an an DT cord-015021-pol2qm74 7050 11 improved improve VBN cord-015021-pol2qm74 7050 12 phagocytic phagocytic JJ cord-015021-pol2qm74 7050 13 function function NN cord-015021-pol2qm74 7050 14 in in IN cord-015021-pol2qm74 7050 15 septic septic JJ cord-015021-pol2qm74 7050 16 shosk shosk NN cord-015021-pol2qm74 7050 17 . . . cord-015021-pol2qm74 7051 1 There there EX cord-015021-pol2qm74 7051 2 are be VBP cord-015021-pol2qm74 7051 3 signs sign NNS cord-015021-pol2qm74 7051 4 for for IN cord-015021-pol2qm74 7051 5 an an DT cord-015021-pol2qm74 7051 6 influence influence NN cord-015021-pol2qm74 7051 7 of of IN cord-015021-pol2qm74 7051 8 nutrient nutrient NN cord-015021-pol2qm74 7051 9 substrates substrate NNS cord-015021-pol2qm74 7051 10 on on IN cord-015021-pol2qm74 7051 11 phagocytosis phagocytosis NN cord-015021-pol2qm74 7051 12 which which WDT cord-015021-pol2qm74 7051 13 seems seem VBZ cord-015021-pol2qm74 7051 14 to to TO cord-015021-pol2qm74 7051 15 be be VB cord-015021-pol2qm74 7051 16 complex complex JJ cord-015021-pol2qm74 7051 17 and and CC cord-015021-pol2qm74 7051 18 should should MD cord-015021-pol2qm74 7051 19 be be VB cord-015021-pol2qm74 7051 20 further further RB cord-015021-pol2qm74 7051 21 investigated investigate VBN cord-015021-pol2qm74 7051 22 . . . cord-015021-pol2qm74 7052 1 ARG ARG NNP cord-015021-pol2qm74 7052 2 and and CC cord-015021-pol2qm74 7052 3 GLN GLN NNP cord-015021-pol2qm74 7052 4 were be VBD cord-015021-pol2qm74 7052 5 lower low JJR cord-015021-pol2qm74 7052 6 in in IN cord-015021-pol2qm74 7052 7 the the DT cord-015021-pol2qm74 7052 8 49%-BCAA 49%-bcaa CD cord-015021-pol2qm74 7052 9 vs vs IN cord-015021-pol2qm74 7052 10 16%-BCAA 16%-bcaa CD cord-015021-pol2qm74 7052 11 group group NN cord-015021-pol2qm74 7052 12 ; ; : cord-015021-pol2qm74 7052 13 ARG ARG NNP cord-015021-pol2qm74 7052 14 was be VBD cord-015021-pol2qm74 7052 15 related relate VBN cord-015021-pol2qm74 7052 16 directly directly RB cord-015021-pol2qm74 7052 17 to to IN cord-015021-pol2qm74 7052 18 ARG arg NN cord-015021-pol2qm74 7052 19 dose dose NN cord-015021-pol2qm74 7052 20 and and CC cord-015021-pol2qm74 7052 21 inversely inversely RB cord-015021-pol2qm74 7052 22 to to IN cord-015021-pol2qm74 7052 23 BCAA BCAA NNP cord-015021-pol2qm74 7052 24 dose dose NN cord-015021-pol2qm74 7052 25 ( ( -LRB- cord-015021-pol2qm74 7052 26 p p NN cord-015021-pol2qm74 7052 27 < < XX cord-015021-pol2qm74 7052 28 O.O01 o.o01 RB cord-015021-pol2qm74 7052 29 for for IN cord-015021-pol2qm74 7052 30 all all DT cord-015021-pol2qm74 7052 31 ) ) -RRB- cord-015021-pol2qm74 7052 32 . . . cord-015021-pol2qm74 7053 1 Clearances clearance NNS cord-015021-pol2qm74 7053 2 of of IN cord-015021-pol2qm74 7053 3 BCAA BCAA NNP cord-015021-pol2qm74 7053 4 increased increase VBD cord-015021-pol2qm74 7053 5 with with IN cord-015021-pol2qm74 7053 6 increasing increase VBG cord-015021-pol2qm74 7053 7 BCAA BCAA NNP cord-015021-pol2qm74 7053 8 dose dose NN cord-015021-pol2qm74 7053 9 ( ( -LRB- cord-015021-pol2qm74 7053 10 p p NN cord-015021-pol2qm74 7053 11 < < XX cord-015021-pol2qm74 7053 12 O.O01 o.o01 NN cord-015021-pol2qm74 7053 13 ) ) -RRB- cord-015021-pol2qm74 7053 14 ; ; : cord-015021-pol2qm74 7053 15 ARG ARG NNP cord-015021-pol2qm74 7053 16 and and CC cord-015021-pol2qm74 7053 17 GLN GLN NNP cord-015021-pol2qm74 7053 18 clearances clearance NNS cord-015021-pol2qm74 7053 19 were be VBD cord-015021-pol2qm74 7053 20 directly directly RB cord-015021-pol2qm74 7053 21 related relate VBN cord-015021-pol2qm74 7053 22 to to IN cord-015021-pol2qm74 7053 23 the the DT cord-015021-pol2qm74 7053 24 BCAA BCAA NNP cord-015021-pol2qm74 7053 25 clearances clearance NNS cord-015021-pol2qm74 7053 26 ( ( -LRB- cord-015021-pol2qm74 7053 27 rZ rZ NNP cord-015021-pol2qm74 7053 28 = = SYM cord-015021-pol2qm74 7053 29 O.65 o.65 NN cord-015021-pol2qm74 7053 30 , , , cord-015021-pol2qm74 7053 31 p p NN cord-015021-pol2qm74 7053 32 < < XX cord-015021-pol2qm74 7053 33 O.O0i O.O0i NNP cord-015021-pol2qm74 7053 34 ) ) -RRB- cord-015021-pol2qm74 7053 35 . . . cord-015021-pol2qm74 7054 1 Relationships relationship NNS cord-015021-pol2qm74 7054 2 between between IN cord-015021-pol2qm74 7054 3 ARG arg NN cord-015021-pol2qm74 7054 4 , , , cord-015021-pol2qm74 7054 5 GLN GLN NNP cord-015021-pol2qm74 7054 6 and and CC cord-015021-pol2qm74 7054 7 other other JJ cord-015021-pol2qm74 7054 8 AA AA NNP cord-015021-pol2qm74 7054 9 seem seem VBP cord-015021-pol2qm74 7054 10 to to TO cord-015021-pol2qm74 7054 11 be be VB cord-015021-pol2qm74 7054 12 ruled rule VBN cord-015021-pol2qm74 7054 13 by by IN cord-015021-pol2qm74 7054 14 patterns pattern NNS cord-015021-pol2qm74 7054 15 involving involve VBG cord-015021-pol2qm74 7054 16 specific specific JJ cord-015021-pol2qm74 7054 17 intracellular intracellular JJ cord-015021-pol2qm74 7054 18 AA AA NNP cord-015021-pol2qm74 7054 19 transport transport NN cord-015021-pol2qm74 7054 20 systems system NNS cord-015021-pol2qm74 7054 21 . . . cord-015021-pol2qm74 7055 1 Regulation regulation NN cord-015021-pol2qm74 7055 2 of of IN cord-015021-pol2qm74 7055 3 ARG arg NN cord-015021-pol2qm74 7055 4 and and CC cord-015021-pol2qm74 7055 5 GLN GLN NNP cord-015021-pol2qm74 7055 6 clearances clearance NNS cord-015021-pol2qm74 7055 7 through through IN cord-015021-pol2qm74 7055 8 BCAA BCAA NNP cord-015021-pol2qm74 7055 9 administration administration NN cord-015021-pol2qm74 7055 10 may may MD cord-015021-pol2qm74 7055 11 be be VB cord-015021-pol2qm74 7055 12 related relate VBN cord-015021-pol2qm74 7055 13 to to IN cord-015021-pol2qm74 7055 14 an an DT cord-015021-pol2qm74 7055 15 increased increase VBN cord-015021-pol2qm74 7055 16 flux flux NN cord-015021-pol2qm74 7055 17 of of IN cord-015021-pol2qm74 7055 18 AA AA NNP cord-015021-pol2qm74 7055 19 into into IN cord-015021-pol2qm74 7055 20 synthetic synthetic JJ cord-015021-pol2qm74 7055 21 processes process NNS cord-015021-pol2qm74 7055 22 . . . cord-015021-pol2qm74 7056 1 Intestinal intestinal JJ cord-015021-pol2qm74 7056 2 segments segment NNS cord-015021-pol2qm74 7056 3 from from IN cord-015021-pol2qm74 7056 4 rats rat NNS cord-015021-pol2qm74 7056 5 immunized immunize VBN cord-015021-pol2qm74 7056 6 by by IN cord-015021-pol2qm74 7056 7 infection infection NN cord-015021-pol2qm74 7056 8 with with IN cord-015021-pol2qm74 7056 9 the the DT cord-015021-pol2qm74 7056 10 nematode nematode NN cord-015021-pol2qm74 7056 11 Trichinella Trichinella NNP cord-015021-pol2qm74 7056 12 spiruUs spiruu NNS cord-015021-pol2qm74 7056 13 undergo undergo VBP cord-015021-pol2qm74 7056 14 intestinal intestinal JJ cord-015021-pol2qm74 7056 15 anaphylaxis anaphylaxis NN cord-015021-pol2qm74 7056 16 or or CC cord-015021-pol2qm74 7056 17 type type NN cord-015021-pol2qm74 7056 18 I -PRON- PRP cord-015021-pol2qm74 7056 19 hypersensitivity hypersensitivity NN cord-015021-pol2qm74 7056 20 when when WRB cord-015021-pol2qm74 7056 21 challenged challenge VBN cord-015021-pol2qm74 7056 22 in in IN cord-015021-pol2qm74 7056 23 vitro vitro FW cord-015021-pol2qm74 7056 24 with with IN cord-015021-pol2qm74 7056 25 parasite parasite NN cord-015021-pol2qm74 7056 26 antigen antigen NN cord-015021-pol2qm74 7056 27 . . . cord-015021-pol2qm74 7057 1 Immunized immunize VBN cord-015021-pol2qm74 7057 2 rats rat NNS cord-015021-pol2qm74 7057 3 exposed expose VBN cord-015021-pol2qm74 7057 4 to to IN cord-015021-pol2qm74 7057 5 T t NN cord-015021-pol2qm74 7057 6 - - HYPH cord-015021-pol2qm74 7057 7 radiation radiation NN cord-015021-pol2qm74 7057 8 ( ( -LRB- cord-015021-pol2qm74 7057 9 7Gy 7Gy NNP cord-015021-pol2qm74 7057 10 ) ) -RRB- cord-015021-pol2qm74 7057 11 and and CC cord-015021-pol2qm74 7057 12 sustained sustain VBD cord-015021-pol2qm74 7057 13 on on IN cord-015021-pol2qm74 7057 14 rat rat NN cord-015021-pol2qm74 7057 15 chow chow NN cord-015021-pol2qm74 7057 16 , , , cord-015021-pol2qm74 7057 17 fail fail VBP cord-015021-pol2qm74 7057 18 to to TO cord-015021-pol2qm74 7057 19 fully fully RB cord-015021-pol2qm74 7057 20 express express VB cord-015021-pol2qm74 7057 21 type type NN cord-015021-pol2qm74 7057 22 I -PRON- PRP cord-015021-pol2qm74 7057 23 hypersensitivity hypersensitivity VBP cord-015021-pol2qm74 7057 24 up up RP cord-015021-pol2qm74 7057 25 to to TO cord-015021-pol2qm74 7057 26 14 14 CD cord-015021-pol2qm74 7057 27 Days day NNS cord-015021-pol2qm74 7058 1 Post Post NNP cord-015021-pol2qm74 7058 2 Irradiation Irradiation NNP cord-015021-pol2qm74 7058 3 ( ( -LRB- cord-015021-pol2qm74 7058 4 DPI DPI NNP cord-015021-pol2qm74 7058 5 ) ) -RRB- cord-015021-pol2qm74 7058 6 . . . cord-015021-pol2qm74 7059 1 We -PRON- PRP cord-015021-pol2qm74 7059 2 hypothesized hypothesize VBD cord-015021-pol2qm74 7059 3 that that IN cord-015021-pol2qm74 7059 4 enteral enteral JJ cord-015021-pol2qm74 7059 5 nutritional nutritional JJ cord-015021-pol2qm74 7059 6 support support NN cord-015021-pol2qm74 7059 7 immediately immediately RB cord-015021-pol2qm74 7059 8 following follow VBG cord-015021-pol2qm74 7059 9 irradiation irradiation NN cord-015021-pol2qm74 7059 10 may may MD cord-015021-pol2qm74 7059 11 be be VB cord-015021-pol2qm74 7059 12 effective effective JJ cord-015021-pol2qm74 7059 13 in in IN cord-015021-pol2qm74 7059 14 preserving preserve VBG cord-015021-pol2qm74 7059 15 mucosal mucosal JJ cord-015021-pol2qm74 7059 16 immune immune JJ cord-015021-pol2qm74 7059 17 responsiveness responsiveness NN cord-015021-pol2qm74 7059 18 or or CC cord-015021-pol2qm74 7059 19 in in IN cord-015021-pol2qm74 7059 20 reducing reduce VBG cord-015021-pol2qm74 7059 21 the the DT cord-015021-pol2qm74 7059 22 recovery recovery NN cord-015021-pol2qm74 7059 23 time time NN cord-015021-pol2qm74 7059 24 after after IN cord-015021-pol2qm74 7059 25 radiation radiation NN cord-015021-pol2qm74 7059 26 - - HYPH cord-015021-pol2qm74 7059 27 induced induce VBN cord-015021-pol2qm74 7059 28 injury injury NN cord-015021-pol2qm74 7059 29 . . . cord-015021-pol2qm74 7060 1 Rats rat NNS cord-015021-pol2qm74 7060 2 were be VBD cord-015021-pol2qm74 7060 3 infected infect VBN cord-015021-pol2qm74 7060 4 with with IN cord-015021-pol2qm74 7060 5 3x103 3x103 CD cord-015021-pol2qm74 7060 6 T.spiralis T.spiralis NNP cord-015021-pol2qm74 7060 7 larvae larva NNS cord-015021-pol2qm74 7060 8 . . . cord-015021-pol2qm74 7061 1 Thirty thirty CD cord-015021-pol2qm74 7061 2 to to TO cord-015021-pol2qm74 7061 3 fifty fifty CD cord-015021-pol2qm74 7061 4 days day NNS cord-015021-pol2qm74 7061 5 later later RBR cord-015021-pol2qm74 7061 6 rats rat NNS cord-015021-pol2qm74 7061 7 received receive VBD cord-015021-pol2qm74 7061 8 7Gy 7Gy NNP cord-015021-pol2qm74 7061 9 T t NN cord-015021-pol2qm74 7061 10 - - HYPH cord-015021-pol2qm74 7061 11 radiation radiation NN cord-015021-pol2qm74 7061 12 from from IN cord-015021-pol2qm74 7061 13 a a DT cord-015021-pol2qm74 7061 14 Co Co NNP cord-015021-pol2qm74 7061 15 source source NN cord-015021-pol2qm74 7061 16 as as IN cord-015021-pol2qm74 7061 17 total total JJ cord-015021-pol2qm74 7061 18 abdominal abdominal JJ cord-015021-pol2qm74 7061 19 irradiation irradiation NN cord-015021-pol2qm74 7061 20 ( ( -LRB- cord-015021-pol2qm74 7061 21 TAI TAI NNP cord-015021-pol2qm74 7061 22 ) ) -RRB- cord-015021-pol2qm74 7061 23 . . . cord-015021-pol2qm74 7062 1 Immediately immediately RB cord-015021-pol2qm74 7062 2 following follow VBG cord-015021-pol2qm74 7062 3 TAI TAI NNP cord-015021-pol2qm74 7062 4 , , , cord-015021-pol2qm74 7062 5 rats rat NNS cord-015021-pol2qm74 7062 6 were be VBD cord-015021-pol2qm74 7062 7 fed feed VBN cord-015021-pol2qm74 7062 8 an an DT cord-015021-pol2qm74 7062 9 elemental elemental JJ cord-015021-pol2qm74 7062 10 amino amino NN cord-015021-pol2qm74 7062 11 acid acid NN cord-015021-pol2qm74 7062 12 diet diet NN cord-015021-pol2qm74 7062 13 ( ( -LRB- cord-015021-pol2qm74 7062 14 EAAD EAAD NNP cord-015021-pol2qm74 7062 15 ) ) -RRB- cord-015021-pol2qm74 7062 16 and and CC cord-015021-pol2qm74 7062 17 at at IN cord-015021-pol2qm74 7062 18 various various JJ cord-015021-pol2qm74 7062 19 DPI DPI NNP cord-015021-pol2qm74 7062 20 sacrificed sacrifice VBD cord-015021-pol2qm74 7062 21 and and CC cord-015021-pol2qm74 7062 22 tested test VBN cord-015021-pol2qm74 7062 23 in in IN cord-015021-pol2qm74 7062 24 Ussing Ussing NNP cord-015021-pol2qm74 7062 25 chambers chamber NNS cord-015021-pol2qm74 7062 26 for for IN cord-015021-pol2qm74 7062 27 local local JJ cord-015021-pol2qm74 7062 28 anaphylaxis anaphylaxis NN cord-015021-pol2qm74 7062 29 , , , cord-015021-pol2qm74 7062 30 expressed express VBN cord-015021-pol2qm74 7062 31 as as IN cord-015021-pol2qm74 7062 32 antigen antigen NN cord-015021-pol2qm74 7062 33 - - HYPH cord-015021-pol2qm74 7062 34 induced induce VBN cord-015021-pol2qm74 7062 35 CI CI NNP cord-015021-pol2qm74 7062 36 secretion secretion NN cord-015021-pol2qm74 7062 37 . . . cord-015021-pol2qm74 7063 1 The the DT cord-015021-pol2qm74 7063 2 normal normal JJ cord-015021-pol2qm74 7063 3 CI CI NNP cord-015021-pol2qm74 7063 4 secretory secretory JJ cord-015021-pol2qm74 7063 5 response response NN cord-015021-pol2qm74 7063 6 to to IN cord-015021-pol2qm74 7063 7 antigenic antigenic JJ cord-015021-pol2qm74 7063 8 challenge challenge NN cord-015021-pol2qm74 7063 9 which which WDT cord-015021-pol2qm74 7063 10 is be VBZ cord-015021-pol2qm74 7063 11 suppressed suppress VBN cord-015021-pol2qm74 7063 12 after after IN cord-015021-pol2qm74 7063 13 irradiation irradiation NN cord-015021-pol2qm74 7063 14 , , , cord-015021-pol2qm74 7063 15 was be VBD cord-015021-pol2qm74 7063 16 restored restore VBN cord-015021-pol2qm74 7063 17 by by IN cord-015021-pol2qm74 7063 18 3 3 CD cord-015021-pol2qm74 7063 19 DPI DPI NNP cord-015021-pol2qm74 7063 20 when when WRB cord-015021-pol2qm74 7063 21 rats rat NNS cord-015021-pol2qm74 7063 22 were be VBD cord-015021-pol2qm74 7063 23 placed place VBN cord-015021-pol2qm74 7063 24 on on IN cord-015021-pol2qm74 7063 25 the the DT cord-015021-pol2qm74 7063 26 EAAD EAAD NNP cord-015021-pol2qm74 7063 27 . . . cord-015021-pol2qm74 7064 1 Antigen antigen NN cord-015021-pol2qm74 7064 2 - - HYPH cord-015021-pol2qm74 7064 3 induced induce VBN cord-015021-pol2qm74 7064 4 C c NN cord-015021-pol2qm74 7064 5 [ [ -LRB- cord-015021-pol2qm74 7064 6 secretion secretion NN cord-015021-pol2qm74 7064 7 is be VBZ cord-015021-pol2qm74 7064 8 dependent dependent JJ cord-015021-pol2qm74 7064 9 on on IN cord-015021-pol2qm74 7064 10 the the DT cord-015021-pol2qm74 7064 11 interaction interaction NN cord-015021-pol2qm74 7064 12 o~ o~ CD cord-015021-pol2qm74 7064 13 antigen antigen NN cord-015021-pol2qm74 7064 14 with with IN cord-015021-pol2qm74 7064 15 specific specific JJ cord-015021-pol2qm74 7064 16 IgE IgE NNP cord-015021-pol2qm74 7064 17 antibodies antibody NNS cord-015021-pol2qm74 7064 18 on on IN cord-015021-pol2qm74 7064 19 the the DT cord-015021-pol2qm74 7064 20 surface surface NN cord-015021-pol2qm74 7064 21 o5 o5 NNP cord-015021-pol2qm74 7064 22 mucosal mucosal NN cord-015021-pol2qm74 7064 23 mast mast NN cord-015021-pol2qm74 7064 24 cells cell NNS cord-015021-pol2qm74 7064 25 and and CC cord-015021-pol2qm74 7064 26 their -PRON- PRP$ cord-015021-pol2qm74 7064 27 subsequent subsequent JJ cord-015021-pol2qm74 7064 28 degranulation degranulation NN cord-015021-pol2qm74 7064 29 . . . cord-015021-pol2qm74 7065 1 Mast mast JJ cord-015021-pol2qm74 7065 2 cell cell NN cord-015021-pol2qm74 7065 3 - - HYPH cord-015021-pol2qm74 7065 4 derived derive VBN cord-015021-pol2qm74 7065 5 5-HT 5-ht CD cord-015021-pol2qm74 7065 6 , , , cord-015021-pol2qm74 7065 7 histamine histamine NN cord-015021-pol2qm74 7065 8 and and CC cord-015021-pol2qm74 7065 9 PG PG NNP cord-015021-pol2qm74 7065 10 , , , cord-015021-pol2qm74 7065 11 together together RB cord-015021-pol2qm74 7065 12 effect effect NN cord-015021-pol2qm74 7065 13 CI CI NNP cord-015021-pol2qm74 7065 14 secretion secretion NN cord-015021-pol2qm74 7065 15 . . . cord-015021-pol2qm74 7066 1 In in IN cord-015021-pol2qm74 7066 2 irradiated irradiate VBN cord-015021-pol2qm74 7066 3 rats rat NNS cord-015021-pol2qm74 7066 4 on on IN cord-015021-pol2qm74 7066 5 rat rat NN cord-015021-pol2qm74 7066 6 chow chow NNP cord-015021-pol2qm74 7066 7 , , , cord-015021-pol2qm74 7066 8 the the DT cord-015021-pol2qm74 7066 9 failure failure NN cord-015021-pol2qm74 7066 10 to to TO cord-015021-pol2qm74 7066 11 respond respond VB cord-015021-pol2qm74 7066 12 to to IN cord-015021-pol2qm74 7066 13 antigenic antigenic JJ cord-015021-pol2qm74 7066 14 challenge challenge NN cord-015021-pol2qm74 7066 15 appears appear VBZ cord-015021-pol2qm74 7066 16 to to TO cord-015021-pol2qm74 7066 17 be be VB cord-015021-pol2qm74 7066 18 associated associate VBN cord-015021-pol2qm74 7066 19 with with IN cord-015021-pol2qm74 7066 20 the the DT cord-015021-pol2qm74 7066 21 destruction destruction NN cord-015021-pol2qm74 7066 22 of of IN cord-015021-pol2qm74 7066 23 mast mast NN cord-015021-pol2qm74 7066 24 cells cell NNS cord-015021-pol2qm74 7066 25 . . . cord-015021-pol2qm74 7067 1 They -PRON- PRP cord-015021-pol2qm74 7067 2 are be VBP cord-015021-pol2qm74 7067 3 undetectable undetectable JJ cord-015021-pol2qm74 7067 4 with with IN cord-015021-pol2qm74 7067 5 standard standard JJ cord-015021-pol2qm74 7067 6 staining stain VBG cord-015021-pol2qm74 7067 7 procedures procedure NNS cord-015021-pol2qm74 7067 8 and and CC cord-015021-pol2qm74 7067 9 mucosal mucosal JJ cord-015021-pol2qm74 7067 10 histamine histamine NN cord-015021-pol2qm74 7067 11 levels level NNS cord-015021-pol2qm74 7067 12 are be VBP cord-015021-pol2qm74 7067 13 drastically drastically RB cord-015021-pol2qm74 7067 14 reduced reduce VBN cord-015021-pol2qm74 7067 15 . . . cord-015021-pol2qm74 7068 1 Also also RB cord-015021-pol2qm74 7068 2 , , , cord-015021-pol2qm74 7068 3 el el NNP cord-015021-pol2qm74 7068 4 secretion secretion NN cord-015021-pol2qm74 7068 5 can can MD cord-015021-pol2qm74 7068 6 be be VB cord-015021-pol2qm74 7068 7 induced induce VBN cord-015021-pol2qm74 7068 8 by by IN cord-015021-pol2qm74 7068 9 direct direct JJ cord-015021-pol2qm74 7068 10 stimulation stimulation NN cord-015021-pol2qm74 7068 11 of of IN cord-015021-pol2qm74 7068 12 epithelium epithelium NN cord-015021-pol2qm74 7068 13 with with IN cord-015021-pol2qm74 7068 14 cr cr NNP cord-015021-pol2qm74 7068 15 secrctagogues secrctagogues NNP cord-015021-pol2qm74 7068 16 and and CC cord-015021-pol2qm74 7068 17 circulating circulate VBG cord-015021-pol2qm74 7068 18 IgE IgE NNP cord-015021-pol2qm74 7068 19 levels level NNS cord-015021-pol2qm74 7068 20 are be VBP cord-015021-pol2qm74 7068 21 normal normal JJ cord-015021-pol2qm74 7068 22 . . . cord-015021-pol2qm74 7069 1 Despite despite IN cord-015021-pol2qm74 7069 2 a a DT cord-015021-pol2qm74 7069 3 more more RBR cord-015021-pol2qm74 7069 4 rapid rapid JJ cord-015021-pol2qm74 7069 5 recovery recovery NN cord-015021-pol2qm74 7069 6 of of IN cord-015021-pol2qm74 7069 7 immune immune JJ cord-015021-pol2qm74 7069 8 responsiveness responsiveness NN cord-015021-pol2qm74 7069 9 in in IN cord-015021-pol2qm74 7069 10 irradiated irradiate VBN cord-015021-pol2qm74 7069 11 rats rat NNS cord-015021-pol2qm74 7069 12 receiving receive VBG cord-015021-pol2qm74 7069 13 EAAD EAAD NNP cord-015021-pol2qm74 7069 14 , , , cord-015021-pol2qm74 7069 15 mast mast NN cord-015021-pol2qm74 7069 16 cells cell NNS cord-015021-pol2qm74 7069 17 were be VBD cord-015021-pol2qm74 7069 18 not not RB cord-015021-pol2qm74 7069 19 restored restore VBN cord-015021-pol2qm74 7069 20 . . . cord-015021-pol2qm74 7070 1 We -PRON- PRP cord-015021-pol2qm74 7070 2 conclude conclude VBP cord-015021-pol2qm74 7070 3 that that IN cord-015021-pol2qm74 7070 4 the the DT cord-015021-pol2qm74 7070 5 EAAD EAAD NNP cord-015021-pol2qm74 7070 6 contributes contribute VBZ cord-015021-pol2qm74 7070 7 to to IN cord-015021-pol2qm74 7070 8 an an DT cord-015021-pol2qm74 7070 9 adaptation adaptation NN cord-015021-pol2qm74 7070 10 that that WDT cord-015021-pol2qm74 7070 11 supports support VBZ cord-015021-pol2qm74 7070 12 the the DT cord-015021-pol2qm74 7070 13 expression expression NN cord-015021-pol2qm74 7070 14 of of IN cord-015021-pol2qm74 7070 15 local local JJ cord-015021-pol2qm74 7070 16 anaphylaxis anaphylaxis NN cord-015021-pol2qm74 7070 17 in in IN cord-015021-pol2qm74 7070 18 the the DT cord-015021-pol2qm74 7070 19 absence absence NN cord-015021-pol2qm74 7070 20 of of IN cord-015021-pol2qm74 7070 21 mast mast NN cord-015021-pol2qm74 7070 22 cells cell NNS cord-015021-pol2qm74 7070 23 . . . cord-015021-pol2qm74 7071 1 Total total JJ cord-015021-pol2qm74 7071 2 parenteral parenteral JJ cord-015021-pol2qm74 7071 3 nutrition nutrition NN cord-015021-pol2qm74 7071 4 ( ( -LRB- cord-015021-pol2qm74 7071 5 PN PN NNP cord-015021-pol2qm74 7071 6 ) ) -RRB- cord-015021-pol2qm74 7071 7 and and CC cord-015021-pol2qm74 7072 1 bowel bowel NN cord-015021-pol2qm74 7072 2 rest rest NN cord-015021-pol2qm74 7072 3 may may MD cord-015021-pol2qm74 7072 4 influence influence VB cord-015021-pol2qm74 7072 5 the the DT cord-015021-pol2qm74 7072 6 host host NN cord-015021-pol2qm74 7072 7 response response NN cord-015021-pol2qm74 7072 8 to to IN cord-015021-pol2qm74 7072 9 infection infection NN cord-015021-pol2qm74 7072 10 . . . cord-015021-pol2qm74 7073 1 This this DT cord-015021-pol2qm74 7073 2 study study NN cord-015021-pol2qm74 7073 3 examined examine VBD cord-015021-pol2qm74 7073 4 the the DT cord-015021-pol2qm74 7073 5 different different JJ cord-015021-pol2qm74 7073 6 host host NN cord-015021-pol2qm74 7073 7 response response NN cord-015021-pol2qm74 7073 8 to to IN cord-015021-pol2qm74 7073 9 infection infection NN cord-015021-pol2qm74 7073 10 in in IN cord-015021-pol2qm74 7073 11 parenterally parenterally NN cord-015021-pol2qm74 7073 12 and and CC cord-015021-pol2qm74 7073 13 enterally enterally RB cord-015021-pol2qm74 7073 14 fed fed JJ cord-015021-pol2qm74 7073 15 animals animal NNS cord-015021-pol2qm74 7073 16 . . . cord-015021-pol2qm74 7074 1 Forty forty CD cord-015021-pol2qm74 7074 2 - - HYPH cord-015021-pol2qm74 7074 3 three three CD cord-015021-pol2qm74 7074 4 rats rat NNS cord-015021-pol2qm74 7074 5 were be VBD cord-015021-pol2qm74 7074 6 divided divide VBN cord-015021-pol2qm74 7074 7 into into IN cord-015021-pol2qm74 7074 8 PN PN NNP cord-015021-pol2qm74 7074 9 group group NN cord-015021-pol2qm74 7074 10 and and CC cord-015021-pol2qm74 7074 11 total total JJ cord-015021-pol2qm74 7074 12 enteral enteral JJ cord-015021-pol2qm74 7074 13 nutrition nutrition NN cord-015021-pol2qm74 7074 14 ( ( -LRB- cord-015021-pol2qm74 7074 15 EN EN NNP cord-015021-pol2qm74 7074 16 ) ) -RRB- cord-015021-pol2qm74 7074 17 group group NN cord-015021-pol2qm74 7074 18 . . . cord-015021-pol2qm74 7075 1 They -PRON- PRP cord-015021-pol2qm74 7075 2 received receive VBD cord-015021-pol2qm74 7075 3 identically identically RB cord-015021-pol2qm74 7075 4 constituted constitute VBN cord-015021-pol2qm74 7075 5 isocaloric isocaloric JJ cord-015021-pol2qm74 7075 6 isonitxogenous isonitxogenous JJ cord-015021-pol2qm74 7075 7 diets diet NNS cord-015021-pol2qm74 7075 8 for for IN cord-015021-pol2qm74 7075 9 seven seven CD cord-015021-pol2qm74 7075 10 days day NNS cord-015021-pol2qm74 7075 11 . . . cord-015021-pol2qm74 7076 1 Animals animal NNS cord-015021-pol2qm74 7076 2 were be VBD cord-015021-pol2qm74 7076 3 then then RB cord-015021-pol2qm74 7076 4 challenged challenge VBN cord-015021-pol2qm74 7076 5 intraperitoneaUy intraperitoneauy NN cord-015021-pol2qm74 7076 6 with with IN cord-015021-pol2qm74 7076 7 3xl(Y 3xl(y CD cord-015021-pol2qm74 7076 8 Escherichia Escherichia NNP cord-015021-pol2qm74 7076 9 Coli Coli NNP cord-015021-pol2qm74 7076 10 and and CC cord-015021-pol2qm74 7076 11 survival survival NN cord-015021-pol2qm74 7076 12 were be VBD cord-015021-pol2qm74 7076 13 observed observe VBN cord-015021-pol2qm74 7076 14 . . . cord-015021-pol2qm74 7077 1 In in IN cord-015021-pol2qm74 7077 2 other other JJ cord-015021-pol2qm74 7077 3 experiments experiment NNS cord-015021-pol2qm74 7077 4 , , , cord-015021-pol2qm74 7077 5 they -PRON- PRP cord-015021-pol2qm74 7077 6 were be VBD cord-015021-pol2qm74 7077 7 sacrificed sacrifice VBN cord-015021-pol2qm74 7077 8 before before RB cord-015021-pol2qm74 7077 9 and and CC cord-015021-pol2qm74 7077 10 two two CD cord-015021-pol2qm74 7077 11 hours hour NNS cord-015021-pol2qm74 7077 12 after after IN cord-015021-pol2qm74 7077 13 bacterial bacterial JJ cord-015021-pol2qm74 7077 14 challenge challenge NN cord-015021-pol2qm74 7077 15 . . . cord-015021-pol2qm74 7078 1 Peritoneal peritoneal JJ cord-015021-pol2qm74 7078 2 cavity cavity NN cord-015021-pol2qm74 7078 3 was be VBD cord-015021-pol2qm74 7078 4 lavaged lavage VBN cord-015021-pol2qm74 7078 5 with with IN cord-015021-pol2qm74 7078 6 10ml 10ml JJ cord-015021-pol2qm74 7078 7 saline saline NN cord-015021-pol2qm74 7078 8 and and CC cord-015021-pol2qm74 7078 9 peritoneal peritoneal JJ cord-015021-pol2qm74 7078 10 exudative exudative JJ cord-015021-pol2qm74 7078 11 cells cell NNS cord-015021-pol2qm74 7078 12 ( ( -LRB- cord-015021-pol2qm74 7078 13 PEC PEC NNP cord-015021-pol2qm74 7078 14 ) ) -RRB- cord-015021-pol2qm74 7078 15 were be VBD cord-015021-pol2qm74 7078 16 harvested harvest VBN cord-015021-pol2qm74 7078 17 and and CC cord-015021-pol2qm74 7078 18 cultured culture VBN cord-015021-pol2qm74 7078 19 in in IN cord-015021-pol2qm74 7078 20 vitro vitro FW cord-015021-pol2qm74 7078 21 for for IN cord-015021-pol2qm74 7078 22 24 24 CD cord-015021-pol2qm74 7078 23 hours hour NNS cord-015021-pol2qm74 7078 24 with with IN cord-015021-pol2qm74 7078 25 and and CC cord-015021-pol2qm74 7078 26 without without IN cord-015021-pol2qm74 7078 27 lipopolysaccharide lipopolysaccharide NN cord-015021-pol2qm74 7078 28 ( ( -LRB- cord-015021-pol2qm74 7078 29 LPS LPS NNP cord-015021-pol2qm74 7078 30 ) ) -RRB- cord-015021-pol2qm74 7078 31 . . . cord-015021-pol2qm74 7079 1 Colony Colony NNP cord-015021-pol2qm74 7079 2 f(m f(m NNP cord-015021-pol2qm74 7079 3 , , , cord-015021-pol2qm74 7079 4 ning ning NN cord-015021-pol2qm74 7079 5 units unit NNS cord-015021-pol2qm74 7079 6 of of IN cord-015021-pol2qm74 7079 7 bacteria bacteria NNS cord-015021-pol2qm74 7079 8 ( ( -LRB- cord-015021-pol2qm74 7079 9 CFU CFU NNP cord-015021-pol2qm74 7079 10 - - HYPH cord-015021-pol2qm74 7079 11 b b NNP cord-015021-pol2qm74 7079 12 ) ) -RRB- cord-015021-pol2qm74 7079 13 in in IN cord-015021-pol2qm74 7079 14 the the DT cord-015021-pol2qm74 7079 15 peritoncal peritoncal JJ cord-015021-pol2qm74 7079 16 lavaged lavaged JJ cord-015021-pol2qm74 7079 17 fluid fluid NN cord-015021-pol2qm74 7079 18 ( ( -LRB- cord-015021-pol2qm74 7079 19 PLF PLF NNP cord-015021-pol2qm74 7079 20 ) ) -RRB- cord-015021-pol2qm74 7079 21 were be VBD cord-015021-pol2qm74 7079 22 determined determine VBN cord-015021-pol2qm74 7079 23 and and CC cord-015021-pol2qm74 7079 24 TNF TNF NNP cord-015021-pol2qm74 7079 25 in in IN cord-015021-pol2qm74 7079 26 the the DT cord-015021-pol2qm74 7079 27 PLF PLF NNP cord-015021-pol2qm74 7079 28 , , , cord-015021-pol2qm74 7079 29 serum serum NN cord-015021-pol2qm74 7079 30 and and CC cord-015021-pol2qm74 7079 31 PEC pec NN cord-015021-pol2qm74 7079 32 culture culture NN cord-015021-pol2qm74 7079 33 supernal supernal JJ cord-015021-pol2qm74 7079 34 , , , cord-015021-pol2qm74 7079 35 ants ant NNS cord-015021-pol2qm74 7079 36 were be VBD cord-015021-pol2qm74 7079 37 measured measure VBN cord-015021-pol2qm74 7079 38 by by IN cord-015021-pol2qm74 7079 39 L929 l929 CD cord-015021-pol2qm74 7079 40 bioassay bioassay NN cord-015021-pol2qm74 7079 41 . . . cord-015021-pol2qm74 7080 1 Twenty twenty CD cord-015021-pol2qm74 7080 2 - - HYPH cord-015021-pol2qm74 7080 3 fonr fonr NN cord-015021-pol2qm74 7080 4 hour hour NN cord-015021-pol2qm74 7080 5 survival survival NN cord-015021-pol2qm74 7080 6 rate rate NN cord-015021-pol2qm74 7080 7 in in IN cord-015021-pol2qm74 7080 8 EN EN NNP cord-015021-pol2qm74 7080 9 group group NN cord-015021-pol2qm74 7080 10 was be VBD cord-015021-pol2qm74 7080 11 significantly significantly RB cord-015021-pol2qm74 7080 12 greater great JJR cord-015021-pol2qm74 7080 13 than than IN cord-015021-pol2qm74 7080 14 that that DT cord-015021-pol2qm74 7080 15 in in IN cord-015021-pol2qm74 7080 16 PN PN NNP cord-015021-pol2qm74 7080 17 group group NN cord-015021-pol2qm74 7080 18 ( ( -LRB- cord-015021-pol2qm74 7080 19 60 60 CD cord-015021-pol2qm74 7080 20 % % NN cord-015021-pol2qm74 7080 21 vs vs IN cord-015021-pol2qm74 7080 22 0 0 CD cord-015021-pol2qm74 7080 23 % % NN cord-015021-pol2qm74 7080 24 ) ) -RRB- cord-015021-pol2qm74 7080 25 . . . cord-015021-pol2qm74 7081 1 The the DT cord-015021-pol2qm74 7081 2 data datum NNS cord-015021-pol2qm74 7081 3 suggest suggest VBP cord-015021-pol2qm74 7081 4 that that IN cord-015021-pol2qm74 7081 5 local local JJ cord-015021-pol2qm74 7081 6 immune immune JJ cord-015021-pol2qm74 7081 7 responses response NNS cord-015021-pol2qm74 7081 8 of of IN cord-015021-pol2qm74 7081 9 PN pn NN cord-015021-pol2qm74 7081 10 - - HYPH cord-015021-pol2qm74 7081 11 treated treat VBN cord-015021-pol2qm74 7081 12 animals animal NNS cord-015021-pol2qm74 7081 13 may may MD cord-015021-pol2qm74 7081 14 be be VB cord-015021-pol2qm74 7081 15 depressed depress VBN cord-015021-pol2qm74 7081 16 with with IN cord-015021-pol2qm74 7081 17 consequent consequent JJ cord-015021-pol2qm74 7081 18 disturbance disturbance NN cord-015021-pol2qm74 7081 19 in in IN cord-015021-pol2qm74 7081 20 the the DT cord-015021-pol2qm74 7081 21 clearance clearance NN cord-015021-pol2qm74 7081 22 of of IN cord-015021-pol2qm74 7081 23 bacteria bacteria NNS cord-015021-pol2qm74 7081 24 . . . cord-015021-pol2qm74 7082 1 This this DT cord-015021-pol2qm74 7082 2 may may MD cord-015021-pol2qm74 7082 3 lead lead VB cord-015021-pol2qm74 7082 4 to to IN cord-015021-pol2qm74 7082 5 a a DT cord-015021-pol2qm74 7082 6 greater great JJR cord-015021-pol2qm74 7082 7 systemic systemic JJ cord-015021-pol2qm74 7082 8 cytokine cytokine NN cord-015021-pol2qm74 7082 9 response response NN cord-015021-pol2qm74 7082 10 and and CC cord-015021-pol2qm74 7082 11 resulting result VBG cord-015021-pol2qm74 7082 12 in in IN cord-015021-pol2qm74 7082 13 a a DT cord-015021-pol2qm74 7082 14 poor poor JJ cord-015021-pol2qm74 7082 15 survival survival NN cord-015021-pol2qm74 7082 16 after after IN cord-015021-pol2qm74 7082 17 bacterial bacterial JJ cord-015021-pol2qm74 7082 18 challenge challenge NN cord-015021-pol2qm74 7082 19 in in IN cord-015021-pol2qm74 7082 20 PN PN NNP cord-015021-pol2qm74 7082 21 group group NN cord-015021-pol2qm74 7082 22 . . . cord-015021-pol2qm74 7083 1 The the DT cord-015021-pol2qm74 7083 2 effects effect NNS cord-015021-pol2qm74 7083 3 of of IN cord-015021-pol2qm74 7083 4 intragastfic intragastfic NN cord-015021-pol2qm74 7083 5 tube tube NN cord-015021-pol2qm74 7083 6 feeding feeding NN cord-015021-pol2qm74 7083 7 of of IN cord-015021-pol2qm74 7083 8 diets diet NNS cord-015021-pol2qm74 7083 9 enriched enrich VBN cord-015021-pol2qm74 7083 10 with with IN cord-015021-pol2qm74 7083 11 m-6 m-6 NNP cord-015021-pol2qm74 7083 12 polyunsaturated polyunsaturated JJ cord-015021-pol2qm74 7083 13 fatty fatty JJ cord-015021-pol2qm74 7083 14 acids acid NNS cord-015021-pol2qm74 7083 15 ( ( -LRB- cord-015021-pol2qm74 7083 16 PUFA PUFA NNP cord-015021-pol2qm74 7083 17 ) ) -RRB- cord-015021-pol2qm74 7083 18 from from IN cord-015021-pol2qm74 7083 19 safflower safflower NN cord-015021-pol2qm74 7083 20 oil oil NN cord-015021-pol2qm74 7083 21 ( ( -LRB- cord-015021-pol2qm74 7083 22 SO so RB cord-015021-pol2qm74 7083 23 ) ) -RRB- cord-015021-pol2qm74 7083 24 or or CC cord-015021-pol2qm74 7083 25 ( ( -LRB- cord-015021-pol2qm74 7083 26 o-3 o-3 JJ cord-015021-pol2qm74 7083 27 PUFA PUFA NNP cord-015021-pol2qm74 7083 28 from from IN cord-015021-pol2qm74 7083 29 menhaden menhaden NN cord-015021-pol2qm74 7083 30 oil oil NN cord-015021-pol2qm74 7083 31 ( ( -LRB- cord-015021-pol2qm74 7083 32 MO MO NNP cord-015021-pol2qm74 7083 33 ) ) -RRB- cord-015021-pol2qm74 7083 34 on on IN cord-015021-pol2qm74 7083 35 eicosanoid eicosanoid JJ cord-015021-pol2qm74 7083 36 production production NN cord-015021-pol2qm74 7083 37 , , , cord-015021-pol2qm74 7083 38 and and CC cord-015021-pol2qm74 7083 39 onthe onthe JJ cord-015021-pol2qm74 7083 40 membrane membrane NN cord-015021-pol2qm74 7083 41 phospholipid phospholipid NN cord-015021-pol2qm74 7083 42 fatty fatty JJ cord-015021-pol2qm74 7083 43 acid acid NN cord-015021-pol2qm74 7083 44 composition composition NN cord-015021-pol2qm74 7083 45 were be VBD cord-015021-pol2qm74 7083 46 investigated investigate VBN cord-015021-pol2qm74 7083 47 in in IN cord-015021-pol2qm74 7083 48 a a DT cord-015021-pol2qm74 7083 49 severe severe JJ cord-015021-pol2qm74 7083 50 acute acute JJ cord-015021-pol2qm74 7083 51 septic septic JJ cord-015021-pol2qm74 7083 52 shock shock NN cord-015021-pol2qm74 7083 53 model model NN cord-015021-pol2qm74 7083 54 . . . cord-015021-pol2qm74 7084 1 The the DT cord-015021-pol2qm74 7084 2 percent percent NN cord-015021-pol2qm74 7084 3 calories calorie NNS cord-015021-pol2qm74 7084 4 from from IN cord-015021-pol2qm74 7084 5 fat fat NN cord-015021-pol2qm74 7084 6 maintained maintain VBN cord-015021-pol2qm74 7084 7 at at IN cord-015021-pol2qm74 7084 8 30 30 CD cord-015021-pol2qm74 7084 9 % % NN cord-015021-pol2qm74 7084 10 in in IN cord-015021-pol2qm74 7084 11 the the DT cord-015021-pol2qm74 7084 12 diets diet NNS cord-015021-pol2qm74 7084 13 was be VBD cord-015021-pol2qm74 7084 14 adjusted adjust VBN cord-015021-pol2qm74 7084 15 to to TO cord-015021-pol2qm74 7084 16 provide provide VB cord-015021-pol2qm74 7084 17 10 10 CD cord-015021-pol2qm74 7084 18 % % NN cord-015021-pol2qm74 7084 19 each each DT cord-015021-pol2qm74 7084 20 of of IN cord-015021-pol2qm74 7084 21 saturated saturate VBN cord-015021-pol2qm74 7084 22 , , , cord-015021-pol2qm74 7084 23 monounsaturated monounsaturated JJ cord-015021-pol2qm74 7084 24 , , , cord-015021-pol2qm74 7084 25 and and CC cord-015021-pol2qm74 7084 26 PUFA PUFA NNP cord-015021-pol2qm74 7084 27 using use VBG cord-015021-pol2qm74 7084 28 olive olive NN cord-015021-pol2qm74 7084 29 oil oil NN cord-015021-pol2qm74 7084 30 and and CC cord-015021-pol2qm74 7084 31 palm palm NN cord-015021-pol2qm74 7084 32 oil oil NN cord-015021-pol2qm74 7084 33 as as IN cord-015021-pol2qm74 7084 34 filler filler NN cord-015021-pol2qm74 7084 35 fats fat NNS cord-015021-pol2qm74 7084 36 . . . cord-015021-pol2qm74 7085 1 After after IN cord-015021-pol2qm74 7085 2 feeding feed VBG cord-015021-pol2qm74 7085 3 for for IN cord-015021-pol2qm74 7085 4 5 5 CD cord-015021-pol2qm74 7085 5 days day NNS cord-015021-pol2qm74 7085 6 , , , cord-015021-pol2qm74 7085 7 lipopolysaccharide lipopolysaccharide NN cord-015021-pol2qm74 7085 8 ( ( -LRB- cord-015021-pol2qm74 7085 9 LPS LPS NNP cord-015021-pol2qm74 7085 10 , , , cord-015021-pol2qm74 7085 11 9mg/100 9mg/100 CD cord-015021-pol2qm74 7085 12 g g NN cord-015021-pol2qm74 7085 13 ) ) -RRB- cord-015021-pol2qm74 7085 14 was be VBD cord-015021-pol2qm74 7085 15 injected inject VBN cord-015021-pol2qm74 7085 16 through through IN cord-015021-pol2qm74 7085 17 the the DT cord-015021-pol2qm74 7085 18 tail tail NN cord-015021-pol2qm74 7085 19 vein vein NN cord-015021-pol2qm74 7085 20 . . . cord-015021-pol2qm74 7086 1 The the DT cord-015021-pol2qm74 7086 2 percent percent NN cord-015021-pol2qm74 7086 3 of of IN cord-015021-pol2qm74 7086 4 animals animal NNS cord-015021-pol2qm74 7086 5 surviving survive VBG cord-015021-pol2qm74 7086 6 in in IN cord-015021-pol2qm74 7086 7 the the DT cord-015021-pol2qm74 7086 8 MO MO NNP cord-015021-pol2qm74 7086 9 group group NN cord-015021-pol2qm74 7086 10 was be VBD cord-015021-pol2qm74 7086 11 67 67 CD cord-015021-pol2qm74 7086 12 % % NN cord-015021-pol2qm74 7086 13 ( ( -LRB- cord-015021-pol2qm74 7086 14 14/21 14/21 CD cord-015021-pol2qm74 7086 15 ) ) -RRB- cord-015021-pol2qm74 7086 16 , , , cord-015021-pol2qm74 7086 17 and and CC cord-015021-pol2qm74 7086 18 did do VBD cord-015021-pol2qm74 7086 19 not not RB cord-015021-pol2qm74 7086 20 differ differ VB cord-015021-pol2qm74 7086 21 significantly significantly RB cord-015021-pol2qm74 7086 22 compared compare VBN cord-015021-pol2qm74 7086 23 to to IN cord-015021-pol2qm74 7086 24 57 57 CD cord-015021-pol2qm74 7086 25 % % NN cord-015021-pol2qm74 7086 26 ( ( -LRB- cord-015021-pol2qm74 7086 27 12/21 12/21 CD cord-015021-pol2qm74 7086 28 ) ) -RRB- cord-015021-pol2qm74 7086 29 in in IN cord-015021-pol2qm74 7086 30 the the DT cord-015021-pol2qm74 7086 31 SO so JJ cord-015021-pol2qm74 7086 32 group group NN cord-015021-pol2qm74 7086 33 . . . cord-015021-pol2qm74 7087 1 The the DT cord-015021-pol2qm74 7087 2 plasma plasma NN cord-015021-pol2qm74 7087 3 concentrations concentration NNS cord-015021-pol2qm74 7087 4 of of IN cord-015021-pol2qm74 7087 5 TNF TNF NNP cord-015021-pol2qm74 7087 6 ct ct NNP cord-015021-pol2qm74 7087 7 for for IN cord-015021-pol2qm74 7087 8 the the DT cord-015021-pol2qm74 7087 9 groups group NNS cord-015021-pol2qm74 7087 10 of of IN cord-015021-pol2qm74 7087 11 animals animal NNS cord-015021-pol2qm74 7087 12 fed feed VBN cord-015021-pol2qm74 7087 13 SO so RB cord-015021-pol2qm74 7088 1 ( ( -LRB- cord-015021-pol2qm74 7088 2 1.2 1.2 CD cord-015021-pol2qm74 7088 3 + + SYM cord-015021-pol2qm74 7088 4 3.0 3.0 CD cord-015021-pol2qm74 7088 5 ng ng NN cord-015021-pol2qm74 7088 6 / / SYM cord-015021-pol2qm74 7088 7 ml ml NN cord-015021-pol2qm74 7088 8 ) ) -RRB- cord-015021-pol2qm74 7088 9 and and CC cord-015021-pol2qm74 7088 10 those those DT cord-015021-pol2qm74 7088 11 fed fed NNP cord-015021-pol2qm74 7088 12 MO MO NNP cord-015021-pol2qm74 7088 13 ( ( -LRB- cord-015021-pol2qm74 7088 14 1.8 1.8 CD cord-015021-pol2qm74 7088 15 + + SYM cord-015021-pol2qm74 7088 16 1.1 1.1 CD cord-015021-pol2qm74 7088 17 ) ) -RRB- cord-015021-pol2qm74 7088 18 did do VBD cord-015021-pol2qm74 7088 19 not not RB cord-015021-pol2qm74 7088 20 differ differ VB cord-015021-pol2qm74 7088 21 significantly significantly RB cord-015021-pol2qm74 7088 22 . . . cord-015021-pol2qm74 7089 1 The the DT cord-015021-pol2qm74 7089 2 levels level NNS cord-015021-pol2qm74 7089 3 of of IN cord-015021-pol2qm74 7089 4 prostaglandin(PG)E2 prostaglandin(PG)E2 NNP cord-015021-pol2qm74 7089 5 , , , cord-015021-pol2qm74 7089 6 6-Keto 6-keto CD cord-015021-pol2qm74 7089 7 - - HYPH cord-015021-pol2qm74 7089 8 PGFlc~ pgflc~ NN cord-015021-pol2qm74 7089 9 and and CC cord-015021-pol2qm74 7089 10 tumor tumor NN cord-015021-pol2qm74 7089 11 necrosis necrosis NN cord-015021-pol2qm74 7089 12 factor factor NN cord-015021-pol2qm74 7089 13 - - HYPH cord-015021-pol2qm74 7089 14 ct ct NN cord-015021-pol2qm74 7090 1 ( ( -LRB- cord-015021-pol2qm74 7090 2 TNF TNF NNP cord-015021-pol2qm74 7090 3 - - HYPH cord-015021-pol2qm74 7090 4 c c NNP cord-015021-pol2qm74 7090 5 0 0 CD cord-015021-pol2qm74 7090 6 were be VBD cord-015021-pol2qm74 7090 7 determined determine VBN cord-015021-pol2qm74 7090 8 90 90 CD cord-015021-pol2qm74 7090 9 min min NN cord-015021-pol2qm74 7090 10 after after IN cord-015021-pol2qm74 7090 11 LPS LPS NNP cord-015021-pol2qm74 7090 12 injection injection NN cord-015021-pol2qm74 7090 13 . . . cord-015021-pol2qm74 7091 1 The the DT cord-015021-pol2qm74 7091 2 fatty fatty JJ cord-015021-pol2qm74 7091 3 composition composition NN cord-015021-pol2qm74 7091 4 ( ( -LRB- cord-015021-pol2qm74 7091 5 relative relative JJ cord-015021-pol2qm74 7091 6 mole% mole% NN cord-015021-pol2qm74 7091 7 ) ) -RRB- cord-015021-pol2qm74 7091 8 of of IN cord-015021-pol2qm74 7091 9 the the DT cord-015021-pol2qm74 7091 10 liver liver NN cord-015021-pol2qm74 7091 11 was be VBD cord-015021-pol2qm74 7091 12 determined determine VBN cord-015021-pol2qm74 7091 13 before before IN cord-015021-pol2qm74 7091 14 ( ( -LRB- cord-015021-pol2qm74 7091 15 LPS- LPS- NNP cord-015021-pol2qm74 7091 16 ) ) -RRB- cord-015021-pol2qm74 7091 17 and and CC cord-015021-pol2qm74 7091 18 3h 3h CD cord-015021-pol2qm74 7091 19 after after IN cord-015021-pol2qm74 7091 20 the the DT cord-015021-pol2qm74 7091 21 LPS LPS NNP cord-015021-pol2qm74 7091 22 administration administration NN cord-015021-pol2qm74 7091 23 ( ( -LRB- cord-015021-pol2qm74 7091 24 LPS+ LPS+ NNP cord-015021-pol2qm74 7091 25 ) ) -RRB- cord-015021-pol2qm74 7091 26 . . . cord-015021-pol2qm74 7092 1 The the DT cord-015021-pol2qm74 7092 2 data datum NNS cord-015021-pol2qm74 7092 3 ( ( -LRB- cord-015021-pol2qm74 7092 4 mean_+SD mean_+sd RB cord-015021-pol2qm74 7092 5 ; ; : cord-015021-pol2qm74 7092 6 n=6 n=6 NNP cord-015021-pol2qm74 7092 7 ) ) -RRB- cord-015021-pol2qm74 7092 8 are be VBP cord-015021-pol2qm74 7092 9 as as IN cord-015021-pol2qm74 7092 10 follows follow NNS cord-015021-pol2qm74 7092 11 . . . cord-015021-pol2qm74 7093 1 Group group NN cord-015021-pol2qm74 7094 1 These these DT cord-015021-pol2qm74 7094 2 data datum NNS cord-015021-pol2qm74 7094 3 indicate indicate VBP cord-015021-pol2qm74 7094 4 that that IN cord-015021-pol2qm74 7094 5 a a DT cord-015021-pol2qm74 7094 6 marked marked JJ cord-015021-pol2qm74 7094 7 reduction reduction NN cord-015021-pol2qm74 7094 8 in in IN cord-015021-pol2qm74 7094 9 the the DT cord-015021-pol2qm74 7094 10 plasma plasma NN cord-015021-pol2qm74 7094 11 levels level NNS cord-015021-pol2qm74 7094 12 of of IN cord-015021-pol2qm74 7094 13 POE2 POE2 NNP cord-015021-pol2qm74 7094 14 and and CC cord-015021-pol2qm74 7094 15 6-Keto 6-keto CD cord-015021-pol2qm74 7094 16 - - HYPH cord-015021-pol2qm74 7094 17 PGFlct PGFlct NNP cord-015021-pol2qm74 7094 18 for for IN cord-015021-pol2qm74 7094 19 rats rat NNS cord-015021-pol2qm74 7094 20 fed fed NNP cord-015021-pol2qm74 7094 21 MO MO NNP cord-015021-pol2qm74 7094 22 diet diet NN cord-015021-pol2qm74 7094 23 was be VBD cord-015021-pol2qm74 7094 24 associated associate VBN cord-015021-pol2qm74 7094 25 with with IN cord-015021-pol2qm74 7094 26 a a DT cord-015021-pol2qm74 7094 27 reduction reduction NN cord-015021-pol2qm74 7094 28 in in IN cord-015021-pol2qm74 7094 29 AA AA NNP cord-015021-pol2qm74 7094 30 which which WDT cord-015021-pol2qm74 7094 31 was be VBD cord-015021-pol2qm74 7094 32 displaced displace VBN cord-015021-pol2qm74 7094 33 by by IN cord-015021-pol2qm74 7094 34 EPA EPA NNP cord-015021-pol2qm74 7094 35 in in IN cord-015021-pol2qm74 7094 36 the the DT cord-015021-pol2qm74 7094 37 membrane membrane NN cord-015021-pol2qm74 7094 38 phospholipids phospholipid NNS cord-015021-pol2qm74 7094 39 . . . cord-015021-pol2qm74 7095 1 Further further RB cord-015021-pol2qm74 7095 2 , , , cord-015021-pol2qm74 7095 3 in in IN cord-015021-pol2qm74 7095 4 these these DT cord-015021-pol2qm74 7095 5 rats rat NNS cord-015021-pol2qm74 7095 6 , , , cord-015021-pol2qm74 7095 7 we -PRON- PRP cord-015021-pol2qm74 7095 8 observed observe VBD cord-015021-pol2qm74 7095 9 that that IN cord-015021-pol2qm74 7095 10 there there EX cord-015021-pol2qm74 7095 11 was be VBD cord-015021-pol2qm74 7095 12 a a DT cord-015021-pol2qm74 7095 13 2.8 2.8 CD cord-015021-pol2qm74 7095 14 % % NN cord-015021-pol2qm74 7095 15 reduction reduction NN cord-015021-pol2qm74 7095 16 in in IN cord-015021-pol2qm74 7095 17 the the DT cord-015021-pol2qm74 7095 18 percent percent NN cord-015021-pol2qm74 7095 19 of of IN cord-015021-pol2qm74 7095 20 EPA EPA NNP cord-015021-pol2qm74 7095 21 following follow VBG cord-015021-pol2qm74 7095 22 LPS LPS NNP cord-015021-pol2qm74 7095 23 challenge challenge NN cord-015021-pol2qm74 7095 24 compared compare VBN cord-015021-pol2qm74 7095 25 to to IN cord-015021-pol2qm74 7095 26 the the DT cord-015021-pol2qm74 7095 27 basal basal NN cord-015021-pol2qm74 7095 28 levels level NNS cord-015021-pol2qm74 7095 29 . . . cord-015021-pol2qm74 7096 1 However however RB cord-015021-pol2qm74 7096 2 , , , cord-015021-pol2qm74 7096 3 for for IN cord-015021-pol2qm74 7096 4 the the DT cord-015021-pol2qm74 7096 5 group group NN cord-015021-pol2qm74 7096 6 of of IN cord-015021-pol2qm74 7096 7 rats rat NNS cord-015021-pol2qm74 7096 8 maintained maintain VBD cord-015021-pol2qm74 7096 9 on on IN cord-015021-pol2qm74 7096 10 SO SO NNP cord-015021-pol2qm74 7096 11 diet diet NN cord-015021-pol2qm74 7096 12 , , , cord-015021-pol2qm74 7096 13 the the DT cord-015021-pol2qm74 7096 14 liver liver NN cord-015021-pol2qm74 7096 15 membrane membrane NN cord-015021-pol2qm74 7096 16 phospholipid phospholipid NN cord-015021-pol2qm74 7096 17 fatty fatty JJ cord-015021-pol2qm74 7096 18 acid acid NN cord-015021-pol2qm74 7096 19 composition composition NN cord-015021-pol2qm74 7096 20 before before IN cord-015021-pol2qm74 7096 21 and and CC cord-015021-pol2qm74 7096 22 after after IN cord-015021-pol2qm74 7096 23 LPS LPS NNP cord-015021-pol2qm74 7096 24 administration administration NN cord-015021-pol2qm74 7096 25 was be VBD cord-015021-pol2qm74 7096 26 unaltered unaltered JJ cord-015021-pol2qm74 7096 27 . . . cord-015021-pol2qm74 7097 1 These these DT cord-015021-pol2qm74 7097 2 finding finding NN cord-015021-pol2qm74 7097 3 suggest suggest VBP cord-015021-pol2qm74 7097 4 that that IN cord-015021-pol2qm74 7097 5 although although IN cord-015021-pol2qm74 7097 6 a a DT cord-015021-pol2qm74 7097 7 reduction reduction NN cord-015021-pol2qm74 7097 8 in in IN cord-015021-pol2qm74 7097 9 AA AA NNP cord-015021-pol2qm74 7097 10 was be VBD cord-015021-pol2qm74 7097 11 associated associate VBN cord-015021-pol2qm74 7097 12 with with IN cord-015021-pol2qm74 7097 13 a a DT cord-015021-pol2qm74 7097 14 decrease decrease NN cord-015021-pol2qm74 7097 15 in in IN cord-015021-pol2qm74 7097 16 the the DT cord-015021-pol2qm74 7097 17 production production NN cord-015021-pol2qm74 7097 18 of of IN cord-015021-pol2qm74 7097 19 pro pro JJ cord-015021-pol2qm74 7097 20 inflammatory inflammatory JJ cord-015021-pol2qm74 7097 21 eicosanoids eicosanoid NNS cord-015021-pol2qm74 7097 22 after after IN cord-015021-pol2qm74 7097 23 5 5 CD cord-015021-pol2qm74 7097 24 days day NNS cord-015021-pol2qm74 7097 25 of of IN cord-015021-pol2qm74 7097 26 continuous continuous JJ cord-015021-pol2qm74 7097 27 MO MO NNP cord-015021-pol2qm74 7097 28 feeding feeding NN cord-015021-pol2qm74 7097 29 , , , cord-015021-pol2qm74 7097 30 there there EX cord-015021-pol2qm74 7097 31 was be VBD cord-015021-pol2qm74 7097 32 no no DT cord-015021-pol2qm74 7097 33 marked marked JJ cord-015021-pol2qm74 7097 34 effect effect NN cord-015021-pol2qm74 7097 35 on on IN cord-015021-pol2qm74 7097 36 the the DT cord-015021-pol2qm74 7097 37 survival survival NN cord-015021-pol2qm74 7097 38 following follow VBG cord-015021-pol2qm74 7097 39 LPS LPS NNP cord-015021-pol2qm74 7097 40 challenge challenge NN cord-015021-pol2qm74 7097 41 . . . cord-015021-pol2qm74 7098 1 Animal animal NN cord-015021-pol2qm74 7098 2 models model NNS cord-015021-pol2qm74 7098 3 have have VBP cord-015021-pol2qm74 7098 4 been be VBN cord-015021-pol2qm74 7098 5 used use VBN cord-015021-pol2qm74 7098 6 to to TO cord-015021-pol2qm74 7098 7 examine examine VB cord-015021-pol2qm74 7098 8 the the DT cord-015021-pol2qm74 7098 9 effects effect NNS cord-015021-pol2qm74 7098 10 of of IN cord-015021-pol2qm74 7098 11 various various JJ cord-015021-pol2qm74 7098 12 nutrients nutrient NNS cord-015021-pol2qm74 7098 13 and and CC cord-015021-pol2qm74 7098 14 nutrient nutrient NN cord-015021-pol2qm74 7098 15 combinations combination NNS cord-015021-pol2qm74 7098 16 upon upon IN cord-015021-pol2qm74 7098 17 the the DT cord-015021-pol2qm74 7098 18 immune immune JJ cord-015021-pol2qm74 7098 19 system system NN cord-015021-pol2qm74 7098 20 . . . cord-015021-pol2qm74 7099 1 We -PRON- PRP cord-015021-pol2qm74 7099 2 studied study VBD cord-015021-pol2qm74 7099 3 the the DT cord-015021-pol2qm74 7099 4 effects effect NNS cord-015021-pol2qm74 7099 5 of of IN cord-015021-pol2qm74 7099 6 standard standard NN cord-015021-pol2qm74 7099 7 and and CC cord-015021-pol2qm74 7099 8 specialized specialized JJ cord-015021-pol2qm74 7099 9 enteral enteral JJ cord-015021-pol2qm74 7099 10 formulations formulation NNS cord-015021-pol2qm74 7099 11 on on IN cord-015021-pol2qm74 7099 12 the the DT cord-015021-pol2qm74 7099 13 response response NN cord-015021-pol2qm74 7099 14 of of IN cord-015021-pol2qm74 7099 15 mice mouse NNS cord-015021-pol2qm74 7099 16 to to IN cord-015021-pol2qm74 7099 17 infectious infectious JJ cord-015021-pol2qm74 7099 18 challenge challenge NN cord-015021-pol2qm74 7099 19 with with IN cord-015021-pol2qm74 7099 20 Listeria Listeria NNP cord-015021-pol2qm74 7099 21 monocytogenes monocytogenes NNP cord-015021-pol2qm74 7099 22 , , , cord-015021-pol2qm74 7099 23 Influenza Influenza NNP cord-015021-pol2qm74 7099 24 A A NNP cord-015021-pol2qm74 7099 25 or or CC cord-015021-pol2qm74 7099 26 Candida Candida NNP cord-015021-pol2qm74 7099 27 albicans albican NNS cord-015021-pol2qm74 7099 28 in in IN cord-015021-pol2qm74 7099 29 order order NN cord-015021-pol2qm74 7099 30 to to TO cord-015021-pol2qm74 7099 31 test test VB cord-015021-pol2qm74 7099 32 the the DT cord-015021-pol2qm74 7099 33 efficacy efficacy NN cord-015021-pol2qm74 7099 34 of of IN cord-015021-pol2qm74 7099 35 specialized specialized JJ cord-015021-pol2qm74 7099 36 ingredients ingredient NNS cord-015021-pol2qm74 7099 37 . . . cord-015021-pol2qm74 7100 1 CF-1 CF-1 NNP cord-015021-pol2qm74 7101 1 outhred outhre VBN cord-015021-pol2qm74 7101 2 female female JJ cord-015021-pol2qm74 7101 3 mice mouse NNS cord-015021-pol2qm74 7101 4 ( ( -LRB- cord-015021-pol2qm74 7101 5 12 12 CD cord-015021-pol2qm74 7101 6 - - SYM cord-015021-pol2qm74 7101 7 15 15 CD cord-015021-pol2qm74 7101 8 g g NN cord-015021-pol2qm74 7101 9 ) ) -RRB- cord-015021-pol2qm74 7101 10 were be VBD cord-015021-pol2qm74 7101 11 fed feed VBN cord-015021-pol2qm74 7101 12 Purina Purina NNP cord-015021-pol2qm74 7101 13 # # NN cord-015021-pol2qm74 7101 14 5002 5002 CD cord-015021-pol2qm74 7101 15 chow chow NN cord-015021-pol2qm74 7101 16 , , , cord-015021-pol2qm74 7101 17 commercially commercially RB cord-015021-pol2qm74 7101 18 available available JJ cord-015021-pol2qm74 7101 19 Osmolite Osmolite NNP cord-015021-pol2qm74 7101 20 HN HN NNP cord-015021-pol2qm74 7102 1 ® ® VB cord-015021-pol2qm74 7102 2 , , , cord-015021-pol2qm74 7102 3 Perative Perative NNP cord-015021-pol2qm74 7102 4 ® ® VBP cord-015021-pol2qm74 7102 5 or or CC cord-015021-pol2qm74 7102 6 Impact Impact NNP cord-015021-pol2qm74 7102 7 * * NFP cord-015021-pol2qm74 7102 8 . . . cord-015021-pol2qm74 7102 9 Mortality mortality NN cord-015021-pol2qm74 7102 10 and and CC cord-015021-pol2qm74 7102 11 tissue tissue NN cord-015021-pol2qm74 7102 12 burden burden NN cord-015021-pol2qm74 7102 13 of of IN cord-015021-pol2qm74 7102 14 pathogen pathogen NN cord-015021-pol2qm74 7102 15 were be VBD cord-015021-pol2qm74 7102 16 examined examine VBN cord-015021-pol2qm74 7102 17 during during IN cord-015021-pol2qm74 7102 18 the the DT cord-015021-pol2qm74 7102 19 21 21 CD cord-015021-pol2qm74 7102 20 d d NN cord-015021-pol2qm74 7102 21 period period NN cord-015021-pol2qm74 7102 22 following follow VBG cord-015021-pol2qm74 7102 23 induced induce VBN cord-015021-pol2qm74 7102 24 infection infection NN cord-015021-pol2qm74 7102 25 . . . cord-015021-pol2qm74 7103 1 The the DT cord-015021-pol2qm74 7103 2 results result NNS cord-015021-pol2qm74 7103 3 indicate indicate VBP cord-015021-pol2qm74 7103 4 that that IN cord-015021-pol2qm74 7103 5 there there EX cord-015021-pol2qm74 7103 6 were be VBD cord-015021-pol2qm74 7103 7 no no DT cord-015021-pol2qm74 7103 8 differences difference NNS cord-015021-pol2qm74 7103 9 between between IN cord-015021-pol2qm74 7103 10 the the DT cord-015021-pol2qm74 7103 11 groups group NNS cord-015021-pol2qm74 7103 12 fed feed VBD cord-015021-pol2qm74 7103 13 the the DT cord-015021-pol2qm74 7103 14 liquid liquid JJ cord-015021-pol2qm74 7103 15 formulas formula NNS cord-015021-pol2qm74 7103 16 with with IN cord-015021-pol2qm74 7103 17 regards regard NNS cord-015021-pol2qm74 7103 18 to to TO cord-015021-pol2qm74 7103 19 mean mean VB cord-015021-pol2qm74 7103 20 survival survival NN cord-015021-pol2qm74 7103 21 time time NN cord-015021-pol2qm74 7103 22 or or CC cord-015021-pol2qm74 7103 23 % % NN cord-015021-pol2qm74 7103 24 survivors survivor NNS cord-015021-pol2qm74 7103 25 in in IN cord-015021-pol2qm74 7103 26 these these DT cord-015021-pol2qm74 7103 27 models model NNS cord-015021-pol2qm74 7103 28 of of IN cord-015021-pol2qm74 7103 29 infection infection NN cord-015021-pol2qm74 7103 30 . . . cord-015021-pol2qm74 7104 1 Examination examination NN cord-015021-pol2qm74 7104 2 of of IN cord-015021-pol2qm74 7104 3 spleens spleen NNS cord-015021-pol2qm74 7104 4 in in IN cord-015021-pol2qm74 7104 5 the the DT cord-015021-pol2qm74 7104 6 groups group NNS cord-015021-pol2qm74 7104 7 challenged challenge VBN cord-015021-pol2qm74 7104 8 with with IN cord-015021-pol2qm74 7104 9 L. L. NNP cord-015021-pol2qm74 7104 10 monocytogenes monocytogene NNS cord-015021-pol2qm74 7104 11 and and CC cord-015021-pol2qm74 7104 12 kidneys kidney NNS cord-015021-pol2qm74 7104 13 in in IN cord-015021-pol2qm74 7104 14 the the DT cord-015021-pol2qm74 7104 15 groups group NNS cord-015021-pol2qm74 7104 16 challenged challenge VBN cord-015021-pol2qm74 7104 17 with with IN cord-015021-pol2qm74 7104 18 C. C. NNP cord-015021-pol2qm74 7104 19 albicans albican NNS cord-015021-pol2qm74 7105 1 revealed reveal VBD cord-015021-pol2qm74 7105 2 no no DT cord-015021-pol2qm74 7105 3 differences difference NNS cord-015021-pol2qm74 7105 4 in in IN cord-015021-pol2qm74 7105 5 tissue tissue NN cord-015021-pol2qm74 7105 6 burden burden NN cord-015021-pol2qm74 7105 7 of of IN cord-015021-pol2qm74 7105 8 pathogenic pathogenic JJ cord-015021-pol2qm74 7105 9 organisms organism NNS cord-015021-pol2qm74 7105 10 . . . cord-015021-pol2qm74 7106 1 Alterations alteration NNS cord-015021-pol2qm74 7106 2 in in IN cord-015021-pol2qm74 7106 3 the the DT cord-015021-pol2qm74 7106 4 length length NN cord-015021-pol2qm74 7106 5 of of IN cord-015021-pol2qm74 7106 6 pre pre NN cord-015021-pol2qm74 7106 7 - - JJ cord-015021-pol2qm74 7106 8 feeding feed VBG cord-015021-pol2qm74 7106 9 from from IN cord-015021-pol2qm74 7106 10 0 0 CD cord-015021-pol2qm74 7106 11 to to TO cord-015021-pol2qm74 7106 12 8 8 CD cord-015021-pol2qm74 7106 13 days day NNS cord-015021-pol2qm74 7106 14 prior prior RB cord-015021-pol2qm74 7106 15 to to IN cord-015021-pol2qm74 7106 16 infection infection NN cord-015021-pol2qm74 7106 17 did do VBD cord-015021-pol2qm74 7106 18 not not RB cord-015021-pol2qm74 7106 19 affect affect VB cord-015021-pol2qm74 7106 20 these these DT cord-015021-pol2qm74 7106 21 results result NNS cord-015021-pol2qm74 7106 22 . . . cord-015021-pol2qm74 7107 1 These these DT cord-015021-pol2qm74 7107 2 data datum NNS cord-015021-pol2qm74 7107 3 demonstrate demonstrate VBP cord-015021-pol2qm74 7107 4 that that IN cord-015021-pol2qm74 7107 5 , , , cord-015021-pol2qm74 7107 6 contrary contrary JJ cord-015021-pol2qm74 7107 7 to to IN cord-015021-pol2qm74 7107 8 previous previous JJ cord-015021-pol2qm74 7107 9 reports report NNS cord-015021-pol2qm74 7107 10 , , , cord-015021-pol2qm74 7107 11 the the DT cord-015021-pol2qm74 7107 12 use use NN cord-015021-pol2qm74 7107 13 of of IN cord-015021-pol2qm74 7107 14 specialized specialized JJ cord-015021-pol2qm74 7107 15 nutrients nutrient NNS cord-015021-pol2qm74 7107 16 did do VBD cord-015021-pol2qm74 7107 17 not not RB cord-015021-pol2qm74 7107 18 improve improve VB cord-015021-pol2qm74 7107 19 resistance resistance NN cord-015021-pol2qm74 7107 20 to to IN cord-015021-pol2qm74 7107 21 disease disease NN cord-015021-pol2qm74 7107 22 in in IN cord-015021-pol2qm74 7107 23 mice mouse NNS cord-015021-pol2qm74 7107 24 challenged challenge VBN cord-015021-pol2qm74 7107 25 with with IN cord-015021-pol2qm74 7107 26 L. L. NNP cord-015021-pol2qm74 7107 27 monocytogenese monocytogenese NN cord-015021-pol2qm74 7107 28 , , , cord-015021-pol2qm74 7107 29 Influenza Influenza NNP cord-015021-pol2qm74 7107 30 A A NNP cord-015021-pol2qm74 7107 31 or or CC cord-015021-pol2qm74 7107 32 C. C. NNP cord-015021-pol2qm74 7107 33 albicans albican NNS cord-015021-pol2qm74 7107 34 as as IN cord-015021-pol2qm74 7107 35 compared compare VBN cord-015021-pol2qm74 7107 36 with with IN cord-015021-pol2qm74 7107 37 mice mouse NNS cord-015021-pol2qm74 7107 38 fed feed VBD cord-015021-pol2qm74 7107 39 Osmolite Osmolite NNP cord-015021-pol2qm74 7107 40 HN HN NNP cord-015021-pol2qm74 7107 41 . . . cord-015021-pol2qm74 7108 1 Animals animal NNS cord-015021-pol2qm74 7108 2 fed feed VBD cord-015021-pol2qm74 7109 1 standard standard NNP cord-015021-pol2qm74 7109 2 chow chow NNP cord-015021-pol2qm74 7109 3 tended tend VBD cord-015021-pol2qm74 7109 4 to to TO cord-015021-pol2qm74 7109 5 be be VB cord-015021-pol2qm74 7109 6 more more RBR cord-015021-pol2qm74 7109 7 resistant resistant JJ cord-015021-pol2qm74 7109 8 to to IN cord-015021-pol2qm74 7109 9 infectious infectious JJ cord-015021-pol2qm74 7109 10 disease disease NN cord-015021-pol2qm74 7109 11 than than IN cord-015021-pol2qm74 7109 12 those those DT cord-015021-pol2qm74 7109 13 fed feed VBD cord-015021-pol2qm74 7109 14 the the DT cord-015021-pol2qm74 7109 15 liquid liquid JJ cord-015021-pol2qm74 7109 16 formulas formula NNS cord-015021-pol2qm74 7109 17 perhaps perhaps RB cord-015021-pol2qm74 7109 18 due due IN cord-015021-pol2qm74 7109 19 to to IN cord-015021-pol2qm74 7109 20 the the DT cord-015021-pol2qm74 7109 21 form form NN cord-015021-pol2qm74 7109 22 of of IN cord-015021-pol2qm74 7109 23 diet diet NN cord-015021-pol2qm74 7109 24 or or CC cord-015021-pol2qm74 7109 25 complexity complexity NN cord-015021-pol2qm74 7109 26 of of IN cord-015021-pol2qm74 7109 27 ingredients ingredient NNS cord-015021-pol2qm74 7109 28 . . . cord-015021-pol2qm74 7110 1 The the DT cord-015021-pol2qm74 7110 2 results result NNS cord-015021-pol2qm74 7110 3 indicate indicate VBP cord-015021-pol2qm74 7110 4 that that IN cord-015021-pol2qm74 7110 5 these these DT cord-015021-pol2qm74 7110 6 animal animal NN cord-015021-pol2qm74 7110 7 models model NNS cord-015021-pol2qm74 7110 8 of of IN cord-015021-pol2qm74 7110 9 infectious infectious JJ cord-015021-pol2qm74 7110 10 challenge challenge NN cord-015021-pol2qm74 7110 11 may may MD cord-015021-pol2qm74 7110 12 be be VB cord-015021-pol2qm74 7110 13 of of IN cord-015021-pol2qm74 7110 14 limited limited JJ cord-015021-pol2qm74 7110 15 use use NN cord-015021-pol2qm74 7110 16 to to TO cord-015021-pol2qm74 7110 17 distinguish distinguish VB cord-015021-pol2qm74 7110 18 effects effect NNS cord-015021-pol2qm74 7110 19 of of IN cord-015021-pol2qm74 7110 20 modified modify VBN cord-015021-pol2qm74 7110 21 nutrient nutrient NN cord-015021-pol2qm74 7110 22 composition composition NN cord-015021-pol2qm74 7110 23 of of IN cord-015021-pol2qm74 7110 24 enteral enteral JJ cord-015021-pol2qm74 7110 25 formulas formula NNS cord-015021-pol2qm74 7110 26 . . . cord-015021-pol2qm74 7111 1 Laboratories laboratory NNS cord-015021-pol2qm74 7112 1 The the DT cord-015021-pol2qm74 7112 2 beneficial beneficial JJ cord-015021-pol2qm74 7112 3 effects effect NNS cord-015021-pol2qm74 7112 4 of of IN cord-015021-pol2qm74 7112 5 sesame sesame NN cord-015021-pol2qm74 7112 6 oil oil NN cord-015021-pol2qm74 7112 7 ( ( -LRB- cord-015021-pol2qm74 7112 8 SES SES NNP cord-015021-pol2qm74 7112 9 ) ) -RRB- cord-015021-pol2qm74 7112 10 have have VBP cord-015021-pol2qm74 7112 11 been be VBN cord-015021-pol2qm74 7112 12 attributed attribute VBN cord-015021-pol2qm74 7112 13 to to IN cord-015021-pol2qm74 7112 14 the the DT cord-015021-pol2qm74 7112 15 presence presence NN cord-015021-pol2qm74 7112 16 ofsesamin ofsesamin NN cord-015021-pol2qm74 7112 17 , , , cord-015021-pol2qm74 7112 18 a a DT cord-015021-pol2qm74 7112 19 non non JJ cord-015021-pol2qm74 7112 20 - - JJ cord-015021-pol2qm74 7112 21 fat fat JJ cord-015021-pol2qm74 7112 22 constituent constituent NN cord-015021-pol2qm74 7112 23 which which WDT cord-015021-pol2qm74 7112 24 is be VBZ cord-015021-pol2qm74 7112 25 claimed claim VBN cord-015021-pol2qm74 7112 26 to to TO cord-015021-pol2qm74 7112 27 iultibit iultibit VB cord-015021-pol2qm74 7112 28 A-5 A-5 NNP cord-015021-pol2qm74 7112 29 desaturase desaturase NN cord-015021-pol2qm74 7112 30 activity activity NN cord-015021-pol2qm74 7112 31 . . . cord-015021-pol2qm74 7113 1 We -PRON- PRP cord-015021-pol2qm74 7113 2 investigated investigate VBD cord-015021-pol2qm74 7113 3 the the DT cord-015021-pol2qm74 7113 4 effects effect NNS cord-015021-pol2qm74 7113 5 of of IN cord-015021-pol2qm74 7113 6 ad ad FW cord-015021-pol2qm74 7113 7 libidum libidum FW cord-015021-pol2qm74 7113 8 feeding feeding NN cord-015021-pol2qm74 7113 9 of of IN cord-015021-pol2qm74 7113 10 SES SES NNP cord-015021-pol2qm74 7113 11 enriched enrich VBN cord-015021-pol2qm74 7113 12 diet diet NN cord-015021-pol2qm74 7113 13 on on IN cord-015021-pol2qm74 7113 14 fatty fatty JJ cord-015021-pol2qm74 7113 15 acid acid NN cord-015021-pol2qm74 7113 16 composition composition NN cord-015021-pol2qm74 7113 17 of of IN cord-015021-pol2qm74 7113 18 phospholipids phospholipid NNS cord-015021-pol2qm74 7113 19 from from IN cord-015021-pol2qm74 7113 20 plasma plasma NN cord-015021-pol2qm74 7113 21 , , , cord-015021-pol2qm74 7113 22 liver liver NN cord-015021-pol2qm74 7113 23 , , , cord-015021-pol2qm74 7113 24 on on IN cord-015021-pol2qm74 7113 25 eicosanoid eicosanoid JJ cord-015021-pol2qm74 7113 26 production production NN cord-015021-pol2qm74 7113 27 , , , cord-015021-pol2qm74 7113 28 and and CC cord-015021-pol2qm74 7113 29 on on IN cord-015021-pol2qm74 7113 30 the the DT cord-015021-pol2qm74 7113 31 protective protective JJ cord-015021-pol2qm74 7113 32 effects effect NNS cord-015021-pol2qm74 7113 33 in in IN cord-015021-pol2qm74 7113 34 mice mouse NNS cord-015021-pol2qm74 7113 35 after after IN cord-015021-pol2qm74 7113 36 cecal cecal JJ cord-015021-pol2qm74 7113 37 ligation ligation NN cord-015021-pol2qm74 7113 38 and and CC cord-015021-pol2qm74 7113 39 puncture puncture NN cord-015021-pol2qm74 7113 40 ( ( -LRB- cord-015021-pol2qm74 7113 41 CLP CLP NNP cord-015021-pol2qm74 7113 42 ) ) -RRB- cord-015021-pol2qm74 7113 43 and and CC cord-015021-pol2qm74 7113 44 compared compare VBN cord-015021-pol2qm74 7113 45 with with IN cord-015021-pol2qm74 7113 46 safflower safflower NN cord-015021-pol2qm74 7113 47 oil oil NN cord-015021-pol2qm74 7113 48 ( ( -LRB- cord-015021-pol2qm74 7113 49 SO so RB cord-015021-pol2qm74 7113 50 ) ) -RRB- cord-015021-pol2qm74 7113 51 diets diet NNS cord-015021-pol2qm74 7113 52 . . . cord-015021-pol2qm74 7114 1 Olive olive NN cord-015021-pol2qm74 7114 2 and and CC cord-015021-pol2qm74 7114 3 palm palm NNP cord-015021-pol2qm74 7114 4 otis otis NNP cord-015021-pol2qm74 7114 5 were be VBD cord-015021-pol2qm74 7114 6 added add VBN cord-015021-pol2qm74 7114 7 as as IN cord-015021-pol2qm74 7114 8 filler filler NN cord-015021-pol2qm74 7114 9 fats fat NNS cord-015021-pol2qm74 7114 10 to to IN cord-015021-pol2qm74 7114 11 the the DT cord-015021-pol2qm74 7114 12 SO so JJ cord-015021-pol2qm74 7114 13 diet diet NN cord-015021-pol2qm74 7114 14 to to TO cord-015021-pol2qm74 7114 15 maintain maintain VB cord-015021-pol2qm74 7114 16 the the DT cord-015021-pol2qm74 7114 17 ratios ratio NNS cord-015021-pol2qm74 7114 18 of of IN cord-015021-pol2qm74 7114 19 saturated saturated JJ cord-015021-pol2qm74 7114 20 , , , cord-015021-pol2qm74 7114 21 and and CC cord-015021-pol2qm74 7114 22 unsaturated unsaturated JJ cord-015021-pol2qm74 7114 23 fatty fatty JJ cord-015021-pol2qm74 7114 24 acids acid NNS cord-015021-pol2qm74 7114 25 similar similar JJ cord-015021-pol2qm74 7114 26 to to IN cord-015021-pol2qm74 7114 27 SES SES NNP cord-015021-pol2qm74 7114 28 diet diet NN cord-015021-pol2qm74 7114 29 . . . cord-015021-pol2qm74 7115 1 Thus thus RB cord-015021-pol2qm74 7115 2 , , , cord-015021-pol2qm74 7115 3 while while IN cord-015021-pol2qm74 7115 4 the the DT cord-015021-pol2qm74 7115 5 total total JJ cord-015021-pol2qm74 7115 6 fat fat NN cord-015021-pol2qm74 7115 7 remained remain VBD cord-015021-pol2qm74 7115 8 at at IN cord-015021-pol2qm74 7115 9 15wt% 15wt% CD cord-015021-pol2qm74 7115 10 , , , cord-015021-pol2qm74 7115 11 the the DT cord-015021-pol2qm74 7115 12 only only JJ cord-015021-pol2qm74 7115 13 difference difference NN cord-015021-pol2qm74 7115 14 between between IN cord-015021-pol2qm74 7115 15 the the DT cord-015021-pol2qm74 7115 16 two two CD cord-015021-pol2qm74 7115 17 diets diet NNS cord-015021-pol2qm74 7115 18 is be VBZ cord-015021-pol2qm74 7115 19 the the DT cord-015021-pol2qm74 7115 20 presence presence NN cord-015021-pol2qm74 7115 21 ofsesamin ofsesamin NN cord-015021-pol2qm74 7115 22 in in IN cord-015021-pol2qm74 7115 23 SES SES NNP cord-015021-pol2qm74 7115 24 diet diet NN cord-015021-pol2qm74 7115 25 . . . cord-015021-pol2qm74 7116 1 The the DT cord-015021-pol2qm74 7116 2 animals animal NNS cord-015021-pol2qm74 7116 3 were be VBD cord-015021-pol2qm74 7116 4 fed feed VBN cord-015021-pol2qm74 7116 5 for for IN cord-015021-pol2qm74 7116 6 3 3 CD cord-015021-pol2qm74 7116 7 weeks week NNS cord-015021-pol2qm74 7116 8 . . . cord-015021-pol2qm74 7117 1 The the DT cord-015021-pol2qm74 7117 2 incorporation incorporation NN cord-015021-pol2qm74 7117 3 of of IN cord-015021-pol2qm74 7117 4 dihomo dihomo NNP cord-015021-pol2qm74 7117 5 - - HYPH cord-015021-pol2qm74 7117 6 y y NNP cord-015021-pol2qm74 7117 7 - - HYPH cord-015021-pol2qm74 7117 8 linolealc linolealc NN cord-015021-pol2qm74 7117 9 acid acid NN cord-015021-pol2qm74 7117 10 ( ( -LRB- cord-015021-pol2qm74 7117 11 DGLA DGLA NNP cord-015021-pol2qm74 7117 12 : : : cord-015021-pol2qm74 7117 13 20:3 20:3 CD cord-015021-pol2qm74 7117 14 o)-6 o)-6 NN cord-015021-pol2qm74 7117 15 ) ) -RRB- cord-015021-pol2qm74 7117 16 in in IN cord-015021-pol2qm74 7117 17 the the DT cord-015021-pol2qm74 7117 18 phospholipids phospholipid NNS cord-015021-pol2qm74 7117 19 from from IN cord-015021-pol2qm74 7117 20 plasma plasma NN cord-015021-pol2qm74 7117 21 and and CC cord-015021-pol2qm74 7117 22 from from IN cord-015021-pol2qm74 7117 23 the the DT cord-015021-pol2qm74 7117 24 liver liver NN cord-015021-pol2qm74 7117 25 for for IN cord-015021-pol2qm74 7117 26 the the DT cord-015021-pol2qm74 7117 27 group group NN cord-015021-pol2qm74 7117 28 of of IN cord-015021-pol2qm74 7117 29 mice mouse NNS cord-015021-pol2qm74 7117 30 fed feed VBN cord-015021-pol2qm74 7117 31 SO so RB cord-015021-pol2qm74 7117 32 diet diet NN cord-015021-pol2qm74 7117 33 ranged range VBD cord-015021-pol2qm74 7117 34 between between IN cord-015021-pol2qm74 7117 35 1 1 CD cord-015021-pol2qm74 7117 36 - - SYM cord-015021-pol2qm74 7117 37 3 3 CD cord-015021-pol2qm74 7117 38 % % NN cord-015021-pol2qm74 7117 39 compared compare VBN cord-015021-pol2qm74 7117 40 to to IN cord-015021-pol2qm74 7117 41 the the DT cord-015021-pol2qm74 7117 42 undetectable undetectable JJ cord-015021-pol2qm74 7117 43 levels level NNS cord-015021-pol2qm74 7117 44 for for IN cord-015021-pol2qm74 7117 45 those those DT cord-015021-pol2qm74 7117 46 fed feed VBN cord-015021-pol2qm74 7117 47 SO SO NNP cord-015021-pol2qm74 7117 48 diet diet NN cord-015021-pol2qm74 7117 49 . . . cord-015021-pol2qm74 7118 1 There there EX cord-015021-pol2qm74 7118 2 were be VBD cord-015021-pol2qm74 7118 3 no no DT cord-015021-pol2qm74 7118 4 significant significant JJ cord-015021-pol2qm74 7118 5 differences difference NNS cord-015021-pol2qm74 7118 6 in in IN cord-015021-pol2qm74 7118 7 the the DT cord-015021-pol2qm74 7118 8 incorporation incorporation NN cord-015021-pol2qm74 7118 9 of of IN cord-015021-pol2qm74 7118 10 other other JJ cord-015021-pol2qm74 7118 11 fatty fatty JJ cord-015021-pol2qm74 7118 12 acids acid NNS cord-015021-pol2qm74 7118 13 either either CC cord-015021-pol2qm74 7118 14 in in IN cord-015021-pol2qm74 7118 15 plasma plasma NN cord-015021-pol2qm74 7118 16 or or CC cord-015021-pol2qm74 7118 17 in in IN cord-015021-pol2qm74 7118 18 the the DT cord-015021-pol2qm74 7118 19 cell cell NN cord-015021-pol2qm74 7118 20 membranes membrane NNS cord-015021-pol2qm74 7118 21 between between IN cord-015021-pol2qm74 7118 22 the the DT cord-015021-pol2qm74 7118 23 two two CD cord-015021-pol2qm74 7118 24 groups group NNS cord-015021-pol2qm74 7118 25 . . . cord-015021-pol2qm74 7119 1 Following follow VBG cord-015021-pol2qm74 7119 2 an an DT cord-015021-pol2qm74 7119 3 intraperitoneal intraperitoneal JJ cord-015021-pol2qm74 7119 4 administration administration NN cord-015021-pol2qm74 7119 5 ofLPS oflp NNS cord-015021-pol2qm74 7119 6 ( ( -LRB- cord-015021-pol2qm74 7119 7 10p.g 10p.g CD cord-015021-pol2qm74 7119 8 / / SYM cord-015021-pol2qm74 7119 9 kg kg NN cord-015021-pol2qm74 7119 10 body body NN cord-015021-pol2qm74 7119 11 wt wt NNP cord-015021-pol2qm74 7119 12 ) ) -RRB- cord-015021-pol2qm74 7119 13 , , , cord-015021-pol2qm74 7119 14 the the DT cord-015021-pol2qm74 7119 15 plasma plasma NN cord-015021-pol2qm74 7119 16 levels level NNS cord-015021-pol2qm74 7119 17 of of IN cord-015021-pol2qm74 7119 18 both both CC cord-015021-pol2qm74 7119 19 PGE2 PGE2 NNP cord-015021-pol2qm74 7119 20 , , , cord-015021-pol2qm74 7119 21 and and CC cord-015021-pol2qm74 7119 22 TxB2 TxB2 NNS cord-015021-pol2qm74 7119 23 , , , cord-015021-pol2qm74 7119 24 were be VBD cord-015021-pol2qm74 7119 25 significantly significantly RB cord-015021-pol2qm74 7119 26 decreased decrease VBN cord-015021-pol2qm74 7119 27 ( ( -LRB- cord-015021-pol2qm74 7119 28 P<0.02 p<0.02 JJ cord-015021-pol2qm74 7119 29 ) ) -RRB- cord-015021-pol2qm74 7119 30 by by IN cord-015021-pol2qm74 7119 31 nearly nearly RB cord-015021-pol2qm74 7119 32 50 50 CD cord-015021-pol2qm74 7119 33 % % NN cord-015021-pol2qm74 7119 34 for for IN cord-015021-pol2qm74 7119 35 the the DT cord-015021-pol2qm74 7119 36 group group NN cord-015021-pol2qm74 7119 37 of of IN cord-015021-pol2qm74 7119 38 animals animal NNS cord-015021-pol2qm74 7119 39 maintained maintain VBN cord-015021-pol2qm74 7119 40 on on IN cord-015021-pol2qm74 7119 41 SES SES NNP cord-015021-pol2qm74 7119 42 diet diet NN cord-015021-pol2qm74 7119 43 compared compare VBN cord-015021-pol2qm74 7119 44 to to IN cord-015021-pol2qm74 7119 45 those those DT cord-015021-pol2qm74 7119 46 maintained maintain VBN cord-015021-pol2qm74 7119 47 on on IN cord-015021-pol2qm74 7119 48 SO so RB cord-015021-pol2qm74 7119 49 diet diet NN cord-015021-pol2qm74 7119 50 . . . cord-015021-pol2qm74 7120 1 These these DT cord-015021-pol2qm74 7120 2 findings finding NNS cord-015021-pol2qm74 7120 3 suggest suggest VBP cord-015021-pol2qm74 7120 4 that that IN cord-015021-pol2qm74 7120 5 sesamin sesamin NNP cord-015021-pol2qm74 7120 6 inhibited inhibit VBD cord-015021-pol2qm74 7120 7 the the DT cord-015021-pol2qm74 7120 8 release release NN cord-015021-pol2qm74 7120 9 of of IN cord-015021-pol2qm74 7120 10 arachidonic arachidonic JJ cord-015021-pol2qm74 7120 11 acid acid NN cord-015021-pol2qm74 7120 12 ( ( -LRB- cord-015021-pol2qm74 7120 13 AA AA NNP cord-015021-pol2qm74 7120 14 ) ) -RRB- cord-015021-pol2qm74 7120 15 which which WDT cord-015021-pol2qm74 7120 16 upon upon IN cord-015021-pol2qm74 7120 17 accumulation accumulation NN cord-015021-pol2qm74 7120 18 is be VBZ cord-015021-pol2qm74 7120 19 retroconverted retroconverte VBN cord-015021-pol2qm74 7120 20 to to IN cord-015021-pol2qm74 7120 21 DGLA DGLA NNP cord-015021-pol2qm74 7120 22 which which WDT cord-015021-pol2qm74 7120 23 could could MD cord-015021-pol2qm74 7120 24 reflect reflect VB cord-015021-pol2qm74 7120 25 a a DT cord-015021-pol2qm74 7120 26 modest modest JJ cord-015021-pol2qm74 7120 27 increase increase NN cord-015021-pol2qm74 7120 28 in in IN cord-015021-pol2qm74 7120 29 the the DT cord-015021-pol2qm74 7120 30 content content NN cord-015021-pol2qm74 7120 31 of of IN cord-015021-pol2qm74 7120 32 DGLA DGLA NNP cord-015021-pol2qm74 7120 33 . . . cord-015021-pol2qm74 7121 1 Failure failure NN cord-015021-pol2qm74 7121 2 to to TO cord-015021-pol2qm74 7121 3 decrease decrease VB cord-015021-pol2qm74 7121 4 the the DT cord-015021-pol2qm74 7121 5 formation formation NN cord-015021-pol2qm74 7121 6 of of IN cord-015021-pol2qm74 7121 7 AA AA NNP cord-015021-pol2qm74 7121 8 could could MD cord-015021-pol2qm74 7121 9 mean mean VB cord-015021-pol2qm74 7121 10 that that IN cord-015021-pol2qm74 7121 11 the the DT cord-015021-pol2qm74 7121 12 effects effect NNS cord-015021-pol2qm74 7121 13 of of IN cord-015021-pol2qm74 7121 14 sesamin sesamin NN cord-015021-pol2qm74 7121 15 on on IN cord-015021-pol2qm74 7121 16 chain chain NN cord-015021-pol2qm74 7121 17 elongation elongation NN cord-015021-pol2qm74 7121 18 process process NN cord-015021-pol2qm74 7121 19 may may MD cord-015021-pol2qm74 7121 20 be be VB cord-015021-pol2qm74 7121 21 after after IN cord-015021-pol2qm74 7121 22 AA AA NNP cord-015021-pol2qm74 7121 23 is be VBZ cord-015021-pol2qm74 7121 24 formed form VBN cord-015021-pol2qm74 7121 25 , , , cord-015021-pol2qm74 7121 26 and and CC cord-015021-pol2qm74 7121 27 that that IN cord-015021-pol2qm74 7121 28 sesamin sesamin NNS cord-015021-pol2qm74 7121 29 may may MD cord-015021-pol2qm74 7121 30 not not RB cord-015021-pol2qm74 7121 31 inhibit inhibit VB cord-015021-pol2qm74 7121 32 A-5 A-5 NNP cord-015021-pol2qm74 7121 33 desaturase desaturase NN cord-015021-pol2qm74 7121 34 activity activity NN cord-015021-pol2qm74 7121 35 . . . cord-015021-pol2qm74 7122 1 On on IN cord-015021-pol2qm74 7122 2 the the DT cord-015021-pol2qm74 7122 3 other other JJ cord-015021-pol2qm74 7122 4 hand hand NN cord-015021-pol2qm74 7122 5 , , , cord-015021-pol2qm74 7122 6 our -PRON- PRP$ cord-015021-pol2qm74 7122 7 data datum NNS cord-015021-pol2qm74 7122 8 suggest suggest VBP cord-015021-pol2qm74 7122 9 that that IN cord-015021-pol2qm74 7122 10 sesamin sesamin NN cord-015021-pol2qm74 7122 11 present present JJ cord-015021-pol2qm74 7122 12 in in IN cord-015021-pol2qm74 7122 13 sesame sesame NN cord-015021-pol2qm74 7122 14 oil oil NN cord-015021-pol2qm74 7122 15 inhibited inhibit VBD cord-015021-pol2qm74 7122 16 the the DT cord-015021-pol2qm74 7122 17 activity activity NN cord-015021-pol2qm74 7122 18 of of IN cord-015021-pol2qm74 7122 19 cyclooxygenase cyclooxygenase NN cord-015021-pol2qm74 7122 20 which which WDT cord-015021-pol2qm74 7122 21 converts convert VBZ cord-015021-pol2qm74 7122 22 AA AA NNP cord-015021-pol2qm74 7122 23 to to IN cord-015021-pol2qm74 7122 24 its -PRON- PRP$ cord-015021-pol2qm74 7122 25 metabolites metabolite NNS cord-015021-pol2qm74 7122 26 ) ) -RRB- cord-015021-pol2qm74 7122 27 , , , cord-015021-pol2qm74 7122 28 or or CC cord-015021-pol2qm74 7122 29 alternatively alternatively RB cord-015021-pol2qm74 7122 30 could could MD cord-015021-pol2qm74 7122 31 block block VB cord-015021-pol2qm74 7122 32 the the DT cord-015021-pol2qm74 7122 33 activity activity NN cord-015021-pol2qm74 7122 34 of of IN cord-015021-pol2qm74 7123 1 phosphalipase phosphalipase NNP cord-015021-pol2qm74 7123 2 A a DT cord-015021-pol2qm74 7123 3 2 2 CD cord-015021-pol2qm74 7124 1 ( ( -LRB- cord-015021-pol2qm74 7124 2 PLA2 PLA2 NNP cord-015021-pol2qm74 7124 3 ) ) -RRB- cord-015021-pol2qm74 7124 4 ( ( -LRB- cord-015021-pol2qm74 7124 5 which which WDT cord-015021-pol2qm74 7124 6 releases release VBZ cord-015021-pol2qm74 7124 7 AA AA NNP cord-015021-pol2qm74 7124 8 from from IN cord-015021-pol2qm74 7124 9 membrane membrane NN cord-015021-pol2qm74 7124 10 phospholipids phospholipid NNS cord-015021-pol2qm74 7124 11 ) ) -RRB- cord-015021-pol2qm74 7124 12 as as IN cord-015021-pol2qm74 7124 13 is be VBZ cord-015021-pol2qm74 7124 14 evident evident JJ cord-015021-pol2qm74 7124 15 from from IN cord-015021-pol2qm74 7124 16 a a DT cord-015021-pol2qm74 7124 17 marked marked JJ cord-015021-pol2qm74 7124 18 decrease decrease NN cord-015021-pol2qm74 7124 19 in in IN cord-015021-pol2qm74 7124 20 eicosanoid eicosanoid JJ cord-015021-pol2qm74 7124 21 production production NN cord-015021-pol2qm74 7124 22 . . . cord-015021-pol2qm74 7125 1 The the DT cord-015021-pol2qm74 7125 2 percentage percentage NN cord-015021-pol2qm74 7125 3 of of IN cord-015021-pol2qm74 7125 4 animals animal NNS cord-015021-pol2qm74 7125 5 surviving survive VBG cord-015021-pol2qm74 7125 6 after after IN cord-015021-pol2qm74 7125 7 cecal cecal JJ cord-015021-pol2qm74 7125 8 ligation ligation NN cord-015021-pol2qm74 7125 9 and and CC cord-015021-pol2qm74 7125 10 puncture puncture NN cord-015021-pol2qm74 7125 11 in in IN cord-015021-pol2qm74 7125 12 rite rite JJ cord-015021-pol2qm74 7125 13 group group NN cord-015021-pol2qm74 7125 14 of of IN cord-015021-pol2qm74 7125 15 mice mouse NNS cord-015021-pol2qm74 7125 16 fed fed NNP cord-015021-pol2qm74 7125 17 SES SES NNP cord-015021-pol2qm74 7125 18 diet diet NN cord-015021-pol2qm74 7125 19 was be VBD cord-015021-pol2qm74 7125 20 65 65 CD cord-015021-pol2qm74 7125 21 % % NN cord-015021-pol2qm74 7125 22 ( ( -LRB- cord-015021-pol2qm74 7125 23 13/20 13/20 CD cord-015021-pol2qm74 7125 24 ) ) -RRB- cord-015021-pol2qm74 7125 25 which which WDT cord-015021-pol2qm74 7125 26 was be VBD cord-015021-pol2qm74 7125 27 markedly markedly RB cord-015021-pol2qm74 7125 28 higher high JJR cord-015021-pol2qm74 7125 29 ( ( -LRB- cord-015021-pol2qm74 7125 30 p<0.01 p<0.01 NN cord-015021-pol2qm74 7125 31 ) ) -RRB- cord-015021-pol2qm74 7125 32 compared compare VBN cord-015021-pol2qm74 7125 33 to to IN cord-015021-pol2qm74 7125 34 only only RB cord-015021-pol2qm74 7125 35 20 20 CD cord-015021-pol2qm74 7125 36 % % NN cord-015021-pol2qm74 7125 37 ( ( -LRB- cord-015021-pol2qm74 7125 38 4/20 4/20 CD cord-015021-pol2qm74 7125 39 ) ) -RRB- cord-015021-pol2qm74 7125 40 for for IN cord-015021-pol2qm74 7125 41 the the DT cord-015021-pol2qm74 7125 42 SO so JJ cord-015021-pol2qm74 7125 43 group group NN cord-015021-pol2qm74 7125 44 . . . cord-015021-pol2qm74 7126 1 Increase increase VB cord-015021-pol2qm74 7126 2 in in IN cord-015021-pol2qm74 7126 3 survival survival NN cord-015021-pol2qm74 7126 4 in in IN cord-015021-pol2qm74 7126 5 the the DT cord-015021-pol2qm74 7126 6 group group NN cord-015021-pol2qm74 7126 7 of of IN cord-015021-pol2qm74 7126 8 mice mouse NNS cord-015021-pol2qm74 7126 9 fed fed NNP cord-015021-pol2qm74 7126 10 SES SES NNP cord-015021-pol2qm74 7126 11 diet diet NN cord-015021-pol2qm74 7126 12 was be VBD cord-015021-pol2qm74 7126 13 associated associate VBN cord-015021-pol2qm74 7126 14 with with IN cord-015021-pol2qm74 7126 15 nearly nearly RB cord-015021-pol2qm74 7126 16 50 50 CD cord-015021-pol2qm74 7126 17 % % NN cord-015021-pol2qm74 7126 18 reduction reduction NN cord-015021-pol2qm74 7126 19 in in IN cord-015021-pol2qm74 7126 20 the the DT cord-015021-pol2qm74 7126 21 production production NN cord-015021-pol2qm74 7126 22 of of IN cord-015021-pol2qm74 7126 23 TNF TNF NNP cord-015021-pol2qm74 7126 24 in in IN cord-015021-pol2qm74 7126 25 response response NN cord-015021-pol2qm74 7126 26 to to IN cord-015021-pol2qm74 7126 27 LPS LPS NNP cord-015021-pol2qm74 7126 28 i.p i.p NNP cord-015021-pol2qm74 7126 29 . . NNP cord-015021-pol2qm74 7126 30 challenge challenge NN cord-015021-pol2qm74 7126 31 , , , cord-015021-pol2qm74 7126 32 for for IN cord-015021-pol2qm74 7126 33 SES SES NNP cord-015021-pol2qm74 7126 34 group group NN cord-015021-pol2qm74 7126 35 compared compare VBN cord-015021-pol2qm74 7126 36 to to IN cord-015021-pol2qm74 7126 37 SO so RB cord-015021-pol2qm74 7126 38 fed fed JJ cord-015021-pol2qm74 7126 39 animals animal NNS cord-015021-pol2qm74 7126 40 . . . cord-015021-pol2qm74 7127 1 Our -PRON- PRP$ cord-015021-pol2qm74 7127 2 data datum NNS cord-015021-pol2qm74 7127 3 suggest suggest VBP cord-015021-pol2qm74 7127 4 that that IN cord-015021-pol2qm74 7127 5 sesamin sesamin NNS cord-015021-pol2qm74 7127 6 , , , cord-015021-pol2qm74 7127 7 present present JJ cord-015021-pol2qm74 7127 8 in in IN cord-015021-pol2qm74 7127 9 sesame sesame NN cord-015021-pol2qm74 7127 10 oil oil NN cord-015021-pol2qm74 7127 11 , , , cord-015021-pol2qm74 7127 12 decreased decrease VBD cord-015021-pol2qm74 7127 13 the the DT cord-015021-pol2qm74 7127 14 production production NN cord-015021-pol2qm74 7127 15 TNF~ tnf~ RB cord-015021-pol2qm74 7127 16 , , , cord-015021-pol2qm74 7127 17 inhibited inhibit VBD cord-015021-pol2qm74 7127 18 the the DT cord-015021-pol2qm74 7127 19 activity activity NN cord-015021-pol2qm74 7127 20 ofPLA ofpla IN cord-015021-pol2qm74 7127 21 2 2 CD cord-015021-pol2qm74 7127 22 and and CC cord-015021-pol2qm74 7127 23 consequently consequently RB cord-015021-pol2qm74 7127 24 offered offer VBD cord-015021-pol2qm74 7127 25 a a DT cord-015021-pol2qm74 7127 26 significant significant JJ cord-015021-pol2qm74 7127 27 protection protection NN cord-015021-pol2qm74 7127 28 against against IN cord-015021-pol2qm74 7127 29 CLP CLP NNP cord-015021-pol2qm74 7127 30 . . . cord-015021-pol2qm74 7128 1 Thus thus RB cord-015021-pol2qm74 7128 2 sesamin sesamin NNP cord-015021-pol2qm74 7128 3 or or CC cord-015021-pol2qm74 7128 4 sesame sesame NN cord-015021-pol2qm74 7128 5 oil oil NN cord-015021-pol2qm74 7128 6 appear appear VBP cord-015021-pol2qm74 7128 7 to to TO cord-015021-pol2qm74 7128 8 be be VB cord-015021-pol2qm74 7128 9 novel novel JJ cord-015021-pol2qm74 7128 10 antiinflammatory antiinflammatory JJ cord-015021-pol2qm74 7128 11 agents agent NNS cord-015021-pol2qm74 7128 12 which which WDT cord-015021-pol2qm74 7128 13 are be VBP cord-015021-pol2qm74 7128 14 present present JJ cord-015021-pol2qm74 7128 15 naturally naturally RB cord-015021-pol2qm74 7128 16 in in IN cord-015021-pol2qm74 7128 17 many many JJ cord-015021-pol2qm74 7128 18 edible edible JJ cord-015021-pol2qm74 7128 19 products product NNS cord-015021-pol2qm74 7128 20 . . . cord-015021-pol2qm74 7129 1 [ [ -LRB- cord-015021-pol2qm74 7129 2 Dept Dept NNP cord-015021-pol2qm74 7129 3 . . . cord-015021-pol2qm74 7130 1 Surgery surgery NN cord-015021-pol2qm74 7130 2 , , , cord-015021-pol2qm74 7130 3 ~E. ~E. NNP cord-015021-pol2qm74 7130 4 Deasoness Deasoness NNP cord-015021-pol2qm74 7130 5 Hosp Hosp NNP cord-015021-pol2qm74 7130 6 . . . cord-015021-pol2qm74 7131 1 , , , cord-015021-pol2qm74 7131 2 Harvard Harvard NNP cord-015021-pol2qm74 7132 1 Medical Medical NNP cord-015021-pol2qm74 7132 2 School School NNP cord-015021-pol2qm74 7132 3 , , , cord-015021-pol2qm74 7132 4 Boston Boston NNP cord-015021-pol2qm74 7132 5 , , , cord-015021-pol2qm74 7132 6 USA USA NNP cord-015021-pol2qm74 7132 7 ] ] -RRB- cord-015021-pol2qm74 7132 8 Stress Stress NNP cord-015021-pol2qm74 7132 9 causes cause VBZ cord-015021-pol2qm74 7132 10 alterations alteration NNS cord-015021-pol2qm74 7132 11 in in IN cord-015021-pol2qm74 7132 12 the the DT cord-015021-pol2qm74 7132 13 homeostasis homeostasis NN cord-015021-pol2qm74 7132 14 of of IN cord-015021-pol2qm74 7132 15 an an DT cord-015021-pol2qm74 7132 16 organism organism NN cord-015021-pol2qm74 7132 17 with with IN cord-015021-pol2qm74 7132 18 major major JJ cord-015021-pol2qm74 7132 19 changes change NNS cord-015021-pol2qm74 7132 20 in in IN cord-015021-pol2qm74 7132 21 various various JJ cord-015021-pol2qm74 7132 22 organs organ NNS cord-015021-pol2qm74 7132 23 , , , cord-015021-pol2qm74 7132 24 lifespans lifespan NNS cord-015021-pol2qm74 7132 25 of of IN cord-015021-pol2qm74 7132 26 cells cell NNS cord-015021-pol2qm74 7132 27 , , , cord-015021-pol2qm74 7132 28 protein protein NN cord-015021-pol2qm74 7132 29 turnovers turnover NNS cord-015021-pol2qm74 7132 30 , , , cord-015021-pol2qm74 7132 31 metabolic metabolic JJ cord-015021-pol2qm74 7132 32 pathways pathway NNS cord-015021-pol2qm74 7132 33 of of IN cord-015021-pol2qm74 7132 34 activation activation NN cord-015021-pol2qm74 7132 35 or or CC cord-015021-pol2qm74 7132 36 stimulation stimulation NN cord-015021-pol2qm74 7132 37 , , , cord-015021-pol2qm74 7132 38 energy energy NN cord-015021-pol2qm74 7132 39 mobilization mobilization NN cord-015021-pol2qm74 7132 40 , , , cord-015021-pol2qm74 7132 41 etc etc FW cord-015021-pol2qm74 7132 42 . . . cord-015021-pol2qm74 7133 1 Punctual punctual JJ cord-015021-pol2qm74 7133 2 changes change NNS cord-015021-pol2qm74 7133 3 have have VBP cord-015021-pol2qm74 7133 4 been be VBN cord-015021-pol2qm74 7133 5 described describe VBN cord-015021-pol2qm74 7133 6 in in IN cord-015021-pol2qm74 7133 7 several several JJ cord-015021-pol2qm74 7133 8 organs organ NNS cord-015021-pol2qm74 7133 9 and and CC cord-015021-pol2qm74 7133 10 various various JJ cord-015021-pol2qm74 7133 11 cell cell NN cord-015021-pol2qm74 7133 12 types type NNS cord-015021-pol2qm74 7133 13 of of IN cord-015021-pol2qm74 7133 14 the the DT cord-015021-pol2qm74 7133 15 nervous nervous JJ cord-015021-pol2qm74 7133 16 , , , cord-015021-pol2qm74 7133 17 endocrine endocrine JJ cord-015021-pol2qm74 7133 18 and and CC cord-015021-pol2qm74 7133 19 immune immune JJ cord-015021-pol2qm74 7133 20 systems system NNS cord-015021-pol2qm74 7133 21 . . . cord-015021-pol2qm74 7134 1 Many many JJ cord-015021-pol2qm74 7134 2 stored store VBN cord-015021-pol2qm74 7134 3 or or CC cord-015021-pol2qm74 7134 4 newly newly RB cord-015021-pol2qm74 7134 5 synthesized synthesize VBN cord-015021-pol2qm74 7134 6 proteins protein NNS cord-015021-pol2qm74 7134 7 are be VBP cord-015021-pol2qm74 7134 8 released release VBN cord-015021-pol2qm74 7134 9 to to IN cord-015021-pol2qm74 7134 10 the the DT cord-015021-pol2qm74 7134 11 bloodstream bloodstream NN cord-015021-pol2qm74 7134 12 to to TO cord-015021-pol2qm74 7134 13 be be VB cord-015021-pol2qm74 7134 14 transported transport VBN cord-015021-pol2qm74 7134 15 to to TO cord-015021-pol2qm74 7134 16 target target VB cord-015021-pol2qm74 7134 17 organs organ NNS cord-015021-pol2qm74 7134 18 or or CC cord-015021-pol2qm74 7134 19 to to TO cord-015021-pol2qm74 7134 20 be be VB cord-015021-pol2qm74 7134 21 disposed dispose VBN cord-015021-pol2qm74 7134 22 of of IN cord-015021-pol2qm74 7134 23 . . . cord-015021-pol2qm74 7135 1 As as IN cord-015021-pol2qm74 7135 2 stress stress NN cord-015021-pol2qm74 7135 3 alters alter VBZ cord-015021-pol2qm74 7135 4 protein protein NN cord-015021-pol2qm74 7135 5 synthesis synthesis NN cord-015021-pol2qm74 7135 6 and and CC cord-015021-pol2qm74 7135 7 requirements requirement NNS cord-015021-pol2qm74 7135 8 in in IN cord-015021-pol2qm74 7135 9 the the DT cord-015021-pol2qm74 7135 10 targets target NNS cord-015021-pol2qm74 7135 11 , , , cord-015021-pol2qm74 7135 12 the the DT cord-015021-pol2qm74 7135 13 bloodstream bloodstream NN cord-015021-pol2qm74 7135 14 is be VBZ cord-015021-pol2qm74 7135 15 a a DT cord-015021-pol2qm74 7135 16 useful useful JJ cord-015021-pol2qm74 7135 17 system system NN cord-015021-pol2qm74 7135 18 for for IN cord-015021-pol2qm74 7135 19 monitoring monitor VBG cord-015021-pol2qm74 7135 20 the the DT cord-015021-pol2qm74 7135 21 relevant relevant JJ cord-015021-pol2qm74 7135 22 changes change NNS cord-015021-pol2qm74 7135 23 . . . cord-015021-pol2qm74 7136 1 We -PRON- PRP cord-015021-pol2qm74 7136 2 present present VBP cord-015021-pol2qm74 7136 3 here here RB cord-015021-pol2qm74 7136 4 the the DT cord-015021-pol2qm74 7136 5 pattern pattern NN cord-015021-pol2qm74 7136 6 of of IN cord-015021-pol2qm74 7136 7 newly newly RB cord-015021-pol2qm74 7136 8 synthesized synthesize VBN cord-015021-pol2qm74 7136 9 or or CC cord-015021-pol2qm74 7136 10 released release VBN cord-015021-pol2qm74 7136 11 serum serum NN cord-015021-pol2qm74 7136 12 proteins protein NNS cord-015021-pol2qm74 7136 13 in in IN cord-015021-pol2qm74 7136 14 C57BL/6 C57BL/6 NNP cord-015021-pol2qm74 7136 15 mice mouse NNS cord-015021-pol2qm74 7136 16 that that WDT cord-015021-pol2qm74 7136 17 have have VBP cord-015021-pol2qm74 7136 18 been be VBN cord-015021-pol2qm74 7136 19 stressed stress VBN cord-015021-pol2qm74 7136 20 by by IN cord-015021-pol2qm74 7136 21 immobilization immobilization NN cord-015021-pol2qm74 7136 22 . . . cord-015021-pol2qm74 7137 1 The the DT cord-015021-pol2qm74 7137 2 proteins protein NNS cord-015021-pol2qm74 7137 3 have have VBP cord-015021-pol2qm74 7137 4 been be VBN cord-015021-pol2qm74 7137 5 labelled label VBN cord-015021-pol2qm74 7137 6 with with IN cord-015021-pol2qm74 7137 7 3sSmethionine 3ssmethionine CD cord-015021-pol2qm74 7137 8 in in IN cord-015021-pol2qm74 7137 9 vivo vivo NN cord-015021-pol2qm74 7137 10 and and CC cord-015021-pol2qm74 7137 11 the the DT cord-015021-pol2qm74 7137 12 study study NN cord-015021-pol2qm74 7137 13 was be VBD cord-015021-pol2qm74 7137 14 performed perform VBN cord-015021-pol2qm74 7137 15 by by IN cord-015021-pol2qm74 7137 16 two two CD cord-015021-pol2qm74 7137 17 dimensional dimensional JJ cord-015021-pol2qm74 7137 18 gel gel NN cord-015021-pol2qm74 7137 19 electrophoresis electrophoresis NN cord-015021-pol2qm74 7137 20 based base VBN cord-015021-pol2qm74 7137 21 on on IN cord-015021-pol2qm74 7137 22 the the DT cord-015021-pol2qm74 7137 23 method method NN cord-015021-pol2qm74 7137 24 originally originally RB cord-015021-pol2qm74 7137 25 described describe VBN cord-015021-pol2qm74 7137 26 by by IN cord-015021-pol2qm74 7137 27 O'Farrel O'Farrel NNP cord-015021-pol2qm74 7137 28 . . . cord-015021-pol2qm74 7138 1 The the DT cord-015021-pol2qm74 7138 2 electrophoretic electrophoretic JJ cord-015021-pol2qm74 7138 3 run run NN cord-015021-pol2qm74 7138 4 was be VBD cord-015021-pol2qm74 7138 5 carried carry VBN cord-015021-pol2qm74 7138 6 out out RP cord-015021-pol2qm74 7138 7 in in IN cord-015021-pol2qm74 7138 8 an an DT cord-015021-pol2qm74 7138 9 ISODALT isodalt NN cord-015021-pol2qm74 7138 10 apparatus apparatus NN cord-015021-pol2qm74 7138 11 . . . cord-015021-pol2qm74 7139 1 A a DT cord-015021-pol2qm74 7139 2 Molecular Molecular NNP cord-015021-pol2qm74 7139 3 Dynamics Dynamics NNPS cord-015021-pol2qm74 7139 4 laser laser NN cord-015021-pol2qm74 7139 5 scanner scanner NN cord-015021-pol2qm74 7139 6 and and CC cord-015021-pol2qm74 7139 7 the the DT cord-015021-pol2qm74 7139 8 Kepler Kepler NNP cord-015021-pol2qm74 7139 9 Image Image NNP cord-015021-pol2qm74 7139 10 Analysis Analysis NNP cord-015021-pol2qm74 7139 11 System System NNP cord-015021-pol2qm74 7139 12 ( ( -LRB- cord-015021-pol2qm74 7139 13 LSB LSB NNP cord-015021-pol2qm74 7139 14 , , , cord-015021-pol2qm74 7139 15 Rockville Rockville NNP cord-015021-pol2qm74 7139 16 , , , cord-015021-pol2qm74 7139 17 USA USA NNP cord-015021-pol2qm74 7139 18 ) ) -RRB- cord-015021-pol2qm74 7139 19 were be VBD cord-015021-pol2qm74 7139 20 used use VBN cord-015021-pol2qm74 7139 21 for for IN cord-015021-pol2qm74 7139 22 modelling model VBG cord-015021-pol2qm74 7139 23 the the DT cord-015021-pol2qm74 7139 24 radiofluorographic radiofluorographic JJ cord-015021-pol2qm74 7139 25 images image NNS cord-015021-pol2qm74 7139 26 . . . cord-015021-pol2qm74 7140 1 The the DT cord-015021-pol2qm74 7140 2 radiofluorographic radiofluorographic JJ cord-015021-pol2qm74 7140 3 images image NNS cord-015021-pol2qm74 7140 4 of of IN cord-015021-pol2qm74 7140 5 the the DT cord-015021-pol2qm74 7140 6 gels gel NNS cord-015021-pol2qm74 7140 7 from from IN cord-015021-pol2qm74 7140 8 serum serum NN cord-015021-pol2qm74 7140 9 samples sample NNS cord-015021-pol2qm74 7140 10 obtained obtain VBN cord-015021-pol2qm74 7140 11 from from IN cord-015021-pol2qm74 7140 12 mice mouse NNS cord-015021-pol2qm74 7140 13 injected inject VBN cord-015021-pol2qm74 7140 14 with with IN cord-015021-pol2qm74 7140 15 I -PRON- PRP cord-015021-pol2qm74 7140 16 mCi mCi NNP cord-015021-pol2qm74 7140 17 of of IN cord-015021-pol2qm74 7140 18 3SS 3ss CD cord-015021-pol2qm74 7140 19 - - HYPH cord-015021-pol2qm74 7140 20 methionine methionine NN cord-015021-pol2qm74 7140 21 reveal reveal VBP cord-015021-pol2qm74 7140 22 about about RB cord-015021-pol2qm74 7140 23 440 440 CD cord-015021-pol2qm74 7140 24 protein protein NN cord-015021-pol2qm74 7140 25 spots spot NNS cord-015021-pol2qm74 7140 26 , , , cord-015021-pol2qm74 7140 27 from from IN cord-015021-pol2qm74 7140 28 which which WDT cord-015021-pol2qm74 7140 29 a a DT cord-015021-pol2qm74 7140 30 small small JJ cord-015021-pol2qm74 7140 31 fraction fraction NN cord-015021-pol2qm74 7140 32 -about -about NN cord-015021-pol2qm74 7140 33 20are 20are NN cord-015021-pol2qm74 7140 34 altered alter VBN cord-015021-pol2qm74 7140 35 in in IN cord-015021-pol2qm74 7140 36 both both DT cord-015021-pol2qm74 7140 37 qualitative qualitative JJ cord-015021-pol2qm74 7140 38 and and CC cord-015021-pol2qm74 7140 39 quantitative quantitative JJ cord-015021-pol2qm74 7140 40 manner manner NN cord-015021-pol2qm74 7140 41 . . . cord-015021-pol2qm74 7141 1 The the DT cord-015021-pol2qm74 7141 2 major major JJ cord-015021-pol2qm74 7141 3 changes change NNS cord-015021-pol2qm74 7141 4 are be VBP cord-015021-pol2qm74 7141 5 in in IN cord-015021-pol2qm74 7141 6 the the DT cord-015021-pol2qm74 7141 7 range range NN cord-015021-pol2qm74 7141 8 of of IN cord-015021-pol2qm74 7141 9 25 25 CD cord-015021-pol2qm74 7141 10 to to TO cord-015021-pol2qm74 7141 11 60.000 60.000 CD cord-015021-pol2qm74 7141 12 d. d. NNP cord-015021-pol2qm74 7142 1 The the DT cord-015021-pol2qm74 7142 2 analysis analysis NN cord-015021-pol2qm74 7142 3 displays display VBZ cord-015021-pol2qm74 7142 4 a a DT cord-015021-pol2qm74 7142 5 highly highly RB cord-015021-pol2qm74 7142 6 reproducible reproducible JJ cord-015021-pol2qm74 7142 7 pattern pattern NN cord-015021-pol2qm74 7142 8 , , , cord-015021-pol2qm74 7142 9 where where WRB cord-015021-pol2qm74 7142 10 clear clear JJ cord-015021-pol2qm74 7142 11 differences difference NNS cord-015021-pol2qm74 7142 12 between between IN cord-015021-pol2qm74 7142 13 stressed stressed JJ cord-015021-pol2qm74 7142 14 and and CC cord-015021-pol2qm74 7142 15 non non JJ cord-015021-pol2qm74 7142 16 - - JJ cord-015021-pol2qm74 7142 17 stressed stress VBN cord-015021-pol2qm74 7142 18 conditions condition NNS cord-015021-pol2qm74 7142 19 are be VBP cord-015021-pol2qm74 7142 20 shown show VBN cord-015021-pol2qm74 7142 21 . . . cord-015021-pol2qm74 7143 1 Differences difference NNS cord-015021-pol2qm74 7143 2 between between IN cord-015021-pol2qm74 7143 3 patterns pattern NNS cord-015021-pol2qm74 7143 4 attributed attribute VBN cord-015021-pol2qm74 7143 5 to to IN cord-015021-pol2qm74 7143 6 chronic chronic JJ cord-015021-pol2qm74 7143 7 vs. vs. IN cord-015021-pol2qm74 7143 8 acute acute JJ cord-015021-pol2qm74 7143 9 stress stress NN cord-015021-pol2qm74 7143 10 will will MD cord-015021-pol2qm74 7143 11 be be VB cord-015021-pol2qm74 7143 12 presented present VBN cord-015021-pol2qm74 7143 13 . . . cord-015021-pol2qm74 7144 1 Patients patient NNS cord-015021-pol2qm74 7144 2 with with IN cord-015021-pol2qm74 7144 3 severe severe JJ cord-015021-pol2qm74 7144 4 trauma trauma NN cord-015021-pol2qm74 7144 5 or or CC cord-015021-pol2qm74 7144 6 major major JJ cord-015021-pol2qm74 7144 7 surgery surgery NN cord-015021-pol2qm74 7144 8 are be VBP cord-015021-pol2qm74 7144 9 known know VBN cord-015021-pol2qm74 7144 10 to to TO cord-015021-pol2qm74 7144 11 acquire acquire VB cord-015021-pol2qm74 7144 12 alterations alteration NNS cord-015021-pol2qm74 7144 13 in in IN cord-015021-pol2qm74 7144 14 neutrophil neutrophil NN cord-015021-pol2qm74 7144 15 functions function NNS cord-015021-pol2qm74 7144 16 which which WDT cord-015021-pol2qm74 7144 17 contribute contribute VBP cord-015021-pol2qm74 7144 18 to to IN cord-015021-pol2qm74 7144 19 their -PRON- PRP$ cord-015021-pol2qm74 7144 20 enhanced enhance VBN cord-015021-pol2qm74 7144 21 susceptibility susceptibility NN cord-015021-pol2qm74 7144 22 towards towards IN cord-015021-pol2qm74 7144 23 microbial microbial JJ cord-015021-pol2qm74 7144 24 infections infection NNS cord-015021-pol2qm74 7144 25 . . . cord-015021-pol2qm74 7145 1 We -PRON- PRP cord-015021-pol2qm74 7145 2 analyzed analyze VBD cord-015021-pol2qm74 7145 3 neutrophil neutrophil NN cord-015021-pol2qm74 7145 4 functions function NNS cord-015021-pol2qm74 7145 5 from from IN cord-015021-pol2qm74 7145 6 fourty fourty CD cord-015021-pol2qm74 7145 7 patients patient NNS cord-015021-pol2qm74 7145 8 admitted admit VBN cord-015021-pol2qm74 7145 9 for for IN cord-015021-pol2qm74 7145 10 major major JJ cord-015021-pol2qm74 7145 11 surgery surgery NN cord-015021-pol2qm74 7145 12 6 6 CD cord-015021-pol2qm74 7145 13 days day NNS cord-015021-pol2qm74 7145 14 and and CC cord-015021-pol2qm74 7145 15 1 1 CD cord-015021-pol2qm74 7145 16 days day NNS cord-015021-pol2qm74 7145 17 preoperatively preoperatively RB cord-015021-pol2qm74 7145 18 and and CC cord-015021-pol2qm74 7145 19 on on IN cord-015021-pol2qm74 7145 20 the the DT cord-015021-pol2qm74 7145 21 ist ist NN cord-015021-pol2qm74 7145 22 and and CC cord-015021-pol2qm74 7145 23 6th 6th JJ cord-015021-pol2qm74 7145 24 postoperative postoperative JJ cord-015021-pol2qm74 7145 25 days day NNS cord-015021-pol2qm74 7146 1 ( ( -LRB- cord-015021-pol2qm74 7146 2 study study NN cord-015021-pol2qm74 7146 3 - - HYPH cord-015021-pol2qm74 7146 4 days day NNS cord-015021-pol2qm74 7146 5 i i PRP cord-015021-pol2qm74 7146 6 , , , cord-015021-pol2qm74 7146 7 2 2 CD cord-015021-pol2qm74 7146 8 , , , cord-015021-pol2qm74 7146 9 3 3 CD cord-015021-pol2qm74 7146 10 , , , cord-015021-pol2qm74 7146 11 and and CC cord-015021-pol2qm74 7146 12 4 4 LS cord-015021-pol2qm74 7146 13 ) ) -RRB- cord-015021-pol2qm74 7146 14 in in IN cord-015021-pol2qm74 7146 15 a a DT cord-015021-pol2qm74 7146 16 randomized randomized JJ cord-015021-pol2qm74 7146 17 placebo placebo NN cord-015021-pol2qm74 7146 18 - - HYPH cord-015021-pol2qm74 7146 19 controlled control VBN cord-015021-pol2qm74 7146 20 double double JJ cord-015021-pol2qm74 7146 21 - - HYPH cord-015021-pol2qm74 7146 22 blind blind JJ cord-015021-pol2qm74 7146 23 study study NN cord-015021-pol2qm74 7146 24 . . . cord-015021-pol2qm74 7147 1 Patients patient NNS cord-015021-pol2qm74 7147 2 were be VBD cord-015021-pol2qm74 7147 3 divided divide VBN cord-015021-pol2qm74 7147 4 into into IN cord-015021-pol2qm74 7147 5 two two CD cord-015021-pol2qm74 7147 6 groups group NNS cord-015021-pol2qm74 7147 7 , , , cord-015021-pol2qm74 7147 8 one one CD cord-015021-pol2qm74 7147 9 ~eceived ~eceived SYM cord-015021-pol2qm74 7147 10 6 6 CD cord-015021-pol2qm74 7147 11 days day NNS cord-015021-pol2qm74 7147 12 preoperatively preoperatively RB cord-015021-pol2qm74 7147 13 an an DT cord-015021-pol2qm74 7147 14 enteral enteral JJ cord-015021-pol2qm74 7147 15 nutrition nutrition NN cord-015021-pol2qm74 7147 16 enriched enrich VBN cord-015021-pol2qm74 7147 17 with with IN cord-015021-pol2qm74 7147 18 omega-3 omega-3 JJ cord-015021-pol2qm74 7147 19 fatty fatty JJ cord-015021-pol2qm74 7147 20 acids acid NNS cord-015021-pol2qm74 7147 21 , , , cord-015021-pol2qm74 7147 22 arginiee arginiee NN cord-015021-pol2qm74 7147 23 , , , cord-015021-pol2qm74 7147 24 and and CC cord-015021-pol2qm74 7147 25 RNA RNA NNP cord-015021-pol2qm74 7147 26 ( ( -LRB- cord-015021-pol2qm74 7147 27 IMPACT IMPACT NNP cord-015021-pol2qm74 7147 28 ) ) -RRB- cord-015021-pol2qm74 7147 29 , , , cord-015021-pol2qm74 7147 30 the the DT cord-015021-pol2qm74 7147 31 other other JJ cord-015021-pol2qm74 7147 32 an an DT cord-015021-pol2qm74 7147 33 isocaloric isocaloric JJ cord-015021-pol2qm74 7147 34 , , , cord-015021-pol2qm74 7147 35 not not RB cord-015021-pol2qm74 7147 36 enriched enrich VBN cord-015021-pol2qm74 7147 37 control control NN cord-015021-pol2qm74 7147 38 nutrition nutrition NN cord-015021-pol2qm74 7147 39 ( ( -LRB- cord-015021-pol2qm74 7147 40 placebo placebo NN cord-015021-pol2qm74 7147 41 ) ) -RRB- cord-015021-pol2qm74 7147 42 . . . cord-015021-pol2qm74 7148 1 Meutrophils meutrophil NNS cord-015021-pol2qm74 7148 2 were be VBD cord-015021-pol2qm74 7148 3 isolated isolate VBN cord-015021-pol2qm74 7148 4 from from IN cord-015021-pol2qm74 7148 5 the the DT cord-015021-pol2qm74 7148 6 peripheral peripheral JJ cord-015021-pol2qm74 7148 7 blood blood NN cord-015021-pol2qm74 7148 8 and and CC cord-015021-pol2qm74 7148 9 stimulated stimulate VBD cord-015021-pol2qm74 7148 10 with with IN cord-015021-pol2qm74 7148 11 the the DT cord-015021-pol2qm74 7148 12 Ca Ca NNP cord-015021-pol2qm74 7148 13 - - HYPH cord-015021-pol2qm74 7148 14 ionophor ionophor NNP cord-015021-pol2qm74 7149 1 A23187 A23187 NNP cord-015021-pol2qm74 7149 2 ( ( -LRB- cord-015021-pol2qm74 7149 3 7.3 7.3 CD cord-015021-pol2qm74 7149 4 pM pm NN cord-015021-pol2qm74 7149 5 ) ) -RRB- cord-015021-pol2qm74 7149 6 . . . cord-015021-pol2qm74 7150 1 The the DT cord-015021-pol2qm74 7150 2 capacity capacity NN cord-015021-pol2qm74 7150 3 of of IN cord-015021-pol2qm74 7150 4 the the DT cord-015021-pol2qm74 7150 5 respective respective JJ cord-015021-pol2qm74 7150 6 neutrophils neutrophil NNS cord-015021-pol2qm74 7150 7 to to TO cord-015021-pol2qm74 7150 8 generate generate VB cord-015021-pol2qm74 7150 9 leukotrienes leukotriene NNS cord-015021-pol2qm74 7150 10 was be VBD cord-015021-pol2qm74 7150 11 analyzed analyze VBN cord-015021-pol2qm74 7150 12 by by IN cord-015021-pol2qm74 7150 13 RP RP NNP cord-015021-pol2qm74 7150 14 - - HYPH cord-015021-pol2qm74 7150 15 HPLC HPLC NNP cord-015021-pol2qm74 7150 16 . . . cord-015021-pol2qm74 7151 1 Neutrophils neutrophils NN cord-015021-pol2qm74 7151 2 from from IN cord-015021-pol2qm74 7151 3 IMPACT impact NN cord-015021-pol2qm74 7151 4 group group NN cord-015021-pol2qm74 7151 5 generated generate VBD cord-015021-pol2qm74 7151 6 significantly significantly RB cord-015021-pol2qm74 7151 7 higher high JJR cord-015021-pol2qm74 7151 8 amounts amount NNS cord-015021-pol2qm74 7151 9 of of IN cord-015021-pol2qm74 7151 10 LTB5 LTB5 NNP cord-015021-pol2qm74 7151 11 ( ( -LRB- cord-015021-pol2qm74 7151 12 mean mean VB cord-015021-pol2qm74 7151 13 values value NNS cord-015021-pol2qm74 7151 14 6.6 6.6 CD cord-015021-pol2qm74 7151 15 ng ng NN cord-015021-pol2qm74 7151 16 / / SYM cord-015021-pol2qm74 7151 17 l l NN cord-015021-pol2qm74 7151 18 x x NNP cord-015021-pol2qm74 7151 19 i~ i~ CD cord-015021-pol2qm74 7151 20 cells cell NNS cord-015021-pol2qm74 7151 21 ) ) -RRB- cord-015021-pol2qm74 7151 22 compared compare VBN cord-015021-pol2qm74 7151 23 to to IN cord-015021-pol2qm74 7151 24 the the DT cord-015021-pol2qm74 7151 25 placebo placebo NN cord-015021-pol2qm74 7151 26 group group NN cord-015021-pol2qm74 7151 27 ( ( -LRB- cord-015021-pol2qm74 7151 28 2.6 2.6 CD cord-015021-pol2qm74 7151 29 ng ng NN cord-015021-pol2qm74 7151 30 ) ) -RRB- cord-015021-pol2qm74 7151 31 at at IN cord-015021-pol2qm74 7151 32 study study NN cord-015021-pol2qm74 7151 33 - - HYPH cord-015021-pol2qm74 7151 34 day day NN cord-015021-pol2qm74 7151 35 2 2 CD cord-015021-pol2qm74 7151 36 [ [ -LRB- cord-015021-pol2qm74 7151 37 p p NN cord-015021-pol2qm74 7151 38 , , , cord-015021-pol2qm74 7151 39 0.01 0.01 CD cord-015021-pol2qm74 7151 40 ) ) -RRB- cord-015021-pol2qm74 7151 41 . . . cord-015021-pol2qm74 7152 1 In in IN cord-015021-pol2qm74 7152 2 contrast contrast NN cord-015021-pol2qm74 7152 3 , , , cord-015021-pol2qm74 7152 4 the the DT cord-015021-pol2qm74 7152 5 capacity capacity NN cord-015021-pol2qm74 7152 6 of of IN cord-015021-pol2qm74 7152 7 neutrophils neutrophil NNS cord-015021-pol2qm74 7152 8 to to TO cord-015021-pol2qm74 7152 9 produce produce VB cord-015021-pol2qm74 7152 10 LTB4 LTB4 NNP cord-015021-pol2qm74 7152 11 was be VBD cord-015021-pol2qm74 7152 12 not not RB cord-015021-pol2qm74 7152 13 significantly significantly RB cord-015021-pol2qm74 7152 14 different different JJ cord-015021-pol2qm74 7152 15 in in IN cord-015021-pol2qm74 7152 16 both both DT cord-015021-pol2qm74 7152 17 patients patient NNS cord-015021-pol2qm74 7152 18 populations population NNS cord-015021-pol2qm74 7152 19 at at IN cord-015021-pol2qm74 7152 20 study study NN cord-015021-pol2qm74 7152 21 - - HYPH cord-015021-pol2qm74 7152 22 days day NNS cord-015021-pol2qm74 7152 23 2 2 CD cord-015021-pol2qm74 7152 24 and and CC cord-015021-pol2qm74 7152 25 3 3 CD cord-015021-pol2qm74 7152 26 . . . cord-015021-pol2qm74 7153 1 The the DT cord-015021-pol2qm74 7153 2 omega omega NN cord-015021-pol2qm74 7153 3 - - HYPH cord-015021-pol2qm74 7153 4 oxidation oxidation NN cord-015021-pol2qm74 7153 5 of of IN cord-015021-pol2qm74 7153 6 LTB4 LTB4 NNP cord-015021-pol2qm74 7153 7 to to IN cord-015021-pol2qm74 7153 8 its -PRON- PRP$ cord-015021-pol2qm74 7153 9 biologically biologically RB cord-015021-pol2qm74 7153 10 less less RBR cord-015021-pol2qm74 7153 11 active active JJ cord-015021-pol2qm74 7153 12 metabolites metabolite NNS cord-015021-pol2qm74 7153 13 OH OH NNP cord-015021-pol2qm74 7153 14 - - HYPH cord-015021-pol2qm74 7153 15 LTB4 LTB4 NNP cord-015021-pol2qm74 7153 16 and and CC cord-015021-pol2qm74 7153 17 COOH COOH NNP cord-015021-pol2qm74 7153 18 - - HYPH cord-015021-pol2qm74 7153 19 LTB4 LTB4 NNP cord-015021-pol2qm74 7153 20 was be VBD cord-015021-pol2qm74 7153 21 not not RB cord-015021-pol2qm74 7153 22 significantly significantly RB cord-015021-pol2qm74 7153 23 different different JJ cord-015021-pol2qm74 7153 24 in in IN cord-015021-pol2qm74 7153 25 both both DT cord-015021-pol2qm74 7153 26 groups group NNS cord-015021-pol2qm74 7153 27 . . . cord-015021-pol2qm74 7154 1 However however RB cord-015021-pol2qm74 7154 2 , , , cord-015021-pol2qm74 7154 3 neutrophils neutrophil NNS cord-015021-pol2qm74 7154 4 from from IN cord-015021-pol2qm74 7154 5 group group NN cord-015021-pol2qm74 7154 6 F F NNP cord-015021-pol2qm74 7154 7 patients patient NNS cord-015021-pol2qm74 7154 8 generate generate VBP cord-015021-pol2qm74 7154 9 more more JJR cord-015021-pol2qm74 7154 10 LTC4 LTC4 NNP cord-015021-pol2qm74 7154 11 at at IN cord-015021-pol2qm74 7154 12 study study NN cord-015021-pol2qm74 7154 13 - - HYPH cord-015021-pol2qm74 7154 14 day day NN cord-015021-pol2qm74 7154 15 2 2 CD cord-015021-pol2qm74 7154 16 ( ( -LRB- cord-015021-pol2qm74 7154 17 p(0/5 p(0/5 NNP cord-015021-pol2qm74 7154 18 ) ) -RRB- cord-015021-pol2qm74 7154 19 . . . cord-015021-pol2qm74 7155 1 The the DT cord-015021-pol2qm74 7155 2 capacity capacity NN cord-015021-pol2qm74 7155 3 of of IN cord-015021-pol2qm74 7155 4 the the DT cord-015021-pol2qm74 7155 5 patients'neutrophils patients'neutrophil NNS cord-015021-pol2qm74 7155 6 to to TO cord-015021-pol2qm74 7155 7 generate generate VB cord-015021-pol2qm74 7155 8 reactive reactive JJ cord-015021-pol2qm74 7155 9 oxygen oxygen NN cord-015021-pol2qm74 7155 10 radicals radical NNS cord-015021-pol2qm74 7155 11 upon upon IN cord-015021-pol2qm74 7155 12 stimulation stimulation NN cord-015021-pol2qm74 7155 13 with with IN cord-015021-pol2qm74 7155 14 fMLP fmlp NN cord-015021-pol2qm74 7155 15 , , , cord-015021-pol2qm74 7155 16 PMA PMA NNP cord-015021-pol2qm74 7155 17 or or CC cord-015021-pol2qm74 7155 18 the the DT cord-015021-pol2qm74 7155 19 Caionopbore Caionopbore NNP cord-015021-pol2qm74 7155 20 A23187 A23187 NNP cord-015021-pol2qm74 7155 21 exhibited exhibit VBD cord-015021-pol2qm74 7155 22 patient patient JJ cord-015021-pol2qm74 7155 23 dependent dependent JJ cord-015021-pol2qm74 7155 24 differences difference NNS cord-015021-pol2qm74 7155 25 but but CC cord-015021-pol2qm74 7155 26 no no DT cord-015021-pol2qm74 7155 27 correlations correlation NNS cord-015021-pol2qm74 7155 28 to to IN cord-015021-pol2qm74 7155 29 the the DT cord-015021-pol2qm74 7155 30 repective repective JJ cord-015021-pol2qm74 7155 31 nutritional nutritional JJ cord-015021-pol2qm74 7155 32 supplementation supplementation NN cord-015021-pol2qm74 7155 33 as as IN cord-015021-pol2qm74 7155 34 was be VBD cord-015021-pol2qm74 7155 35 measured measure VBN cord-015021-pol2qm74 7155 36 by by IN cord-015021-pol2qm74 7155 37 luminol luminol NN cord-015021-pol2qm74 7155 38 dependent dependent JJ cord-015021-pol2qm74 7155 39 ohemiluminescense= ohemiluminescense= RB cord-015021-pol2qm74 7156 1 These these DT cord-015021-pol2qm74 7156 2 data datum NNS cord-015021-pol2qm74 7156 3 indicate indicate VBP cord-015021-pol2qm74 7156 4 that that IN cord-015021-pol2qm74 7156 5 an an DT cord-015021-pol2qm74 7156 6 enteral enteral JJ cord-015021-pol2qm74 7156 7 nutrition nutrition NN cord-015021-pol2qm74 7156 8 enriched enrich VBN cord-015021-pol2qm74 7156 9 in in IN cord-015021-pol2qm74 7156 10 omega-3 omega-3 JJ cord-015021-pol2qm74 7156 11 fatty fatty JJ cord-015021-pol2qm74 7156 12 acids acid NNS cord-015021-pol2qm74 7156 13 lead lead VBP cord-015021-pol2qm74 7156 14 to to IN cord-015021-pol2qm74 7156 15 alterations alteration NNS cord-015021-pol2qm74 7156 16 in in IN cord-015021-pol2qm74 7156 17 distinct distinct JJ cord-015021-pol2qm74 7156 18 parameters parameter NNS cord-015021-pol2qm74 7156 19 of of IN cord-015021-pol2qm74 7156 20 neutrophil neutrophil NN cord-015021-pol2qm74 7156 21 functions function NNS cord-015021-pol2qm74 7156 22 . . . cord-015021-pol2qm74 7157 1 Clinical clinical JJ cord-015021-pol2qm74 7157 2 patient patient NN cord-015021-pol2qm74 7157 3 characteristics characteristic NNS cord-015021-pol2qm74 7157 4 and and CC cord-015021-pol2qm74 7157 5 mean mean VB cord-015021-pol2qm74 7157 6 caloric caloric JJ cord-015021-pol2qm74 7157 7 intake intake NN cord-015021-pol2qm74 7157 8 were be VBD cord-015021-pol2qm74 7157 9 similar similar JJ cord-015021-pol2qm74 7157 10 between between IN cord-015021-pol2qm74 7157 11 the the DT cord-015021-pol2qm74 7157 12 two two CD cord-015021-pol2qm74 7157 13 groups group NNS cord-015021-pol2qm74 7157 14 . . . cord-015021-pol2qm74 7158 1 Both both DT cord-015021-pol2qm74 7158 2 formula formula NN cord-015021-pol2qm74 7158 3 were be VBD cord-015021-pol2qm74 7158 4 tolerated tolerate VBN cord-015021-pol2qm74 7158 5 well well RB cord-015021-pol2qm74 7158 6 and and CC cord-015021-pol2qm74 7158 7 the the DT cord-015021-pol2qm74 7158 8 incidence incidence NN cord-015021-pol2qm74 7158 9 of of IN cord-015021-pol2qm74 7158 10 diarrhea diarrhea NN cord-015021-pol2qm74 7158 11 was be VBD cord-015021-pol2qm74 7158 12 low low JJ cord-015021-pol2qm74 7158 13 . . . cord-015021-pol2qm74 7159 1 The the DT cord-015021-pol2qm74 7159 2 number number NN cord-015021-pol2qm74 7159 3 of of IN cord-015021-pol2qm74 7159 4 infectious infectious JJ cord-015021-pol2qm74 7159 5 and and CC cord-015021-pol2qm74 7159 6 wound wound JJ cord-015021-pol2qm74 7159 7 complications complication NNS cord-015021-pol2qm74 7159 8 as as RB cord-015021-pol2qm74 7159 9 well well RB cord-015021-pol2qm74 7159 10 as as IN cord-015021-pol2qm74 7159 11 the the DT cord-015021-pol2qm74 7159 12 APACHE APACHE NNP cord-015021-pol2qm74 7159 13 II II NNP cord-015021-pol2qm74 7159 14 score score NN cord-015021-pol2qm74 7159 15 was be VBD cord-015021-pol2qm74 7159 16 evaluated evaluate VBN cord-015021-pol2qm74 7159 17 for for IN cord-015021-pol2qm74 7159 18 the the DT cord-015021-pol2qm74 7159 19 two two CD cord-015021-pol2qm74 7159 20 study study NN cord-015021-pol2qm74 7159 21 groups group NNS cord-015021-pol2qm74 7159 22 . . . cord-015021-pol2qm74 7160 1 Although although IN cord-015021-pol2qm74 7160 2 the the DT cord-015021-pol2qm74 7160 3 number number NN cord-015021-pol2qm74 7160 4 of of IN cord-015021-pol2qm74 7160 5 complications complication NNS cord-015021-pol2qm74 7160 6 in in IN cord-015021-pol2qm74 7160 7 the the DT cord-015021-pol2qm74 7160 8 group group NN cord-015021-pol2qm74 7160 9 supplemented supplement VBN cord-015021-pol2qm74 7160 10 with with IN cord-015021-pol2qm74 7160 11 arginine arginine NN cord-015021-pol2qm74 7160 12 , , , cord-015021-pol2qm74 7160 13 RNA RNA NNP cord-015021-pol2qm74 7160 14 and and CC cord-015021-pol2qm74 7160 15 omega-3 omega-3 JJ cord-015021-pol2qm74 7160 16 fatty fatty JJ cord-015021-pol2qm74 7160 17 acids acid NNS cord-015021-pol2qm74 7160 18 was be VBD cord-015021-pol2qm74 7160 19 lower low JJR cord-015021-pol2qm74 7160 20 no no DT cord-015021-pol2qm74 7160 21 significant significant JJ cord-015021-pol2qm74 7160 22 difference difference NN cord-015021-pol2qm74 7160 23 in in IN cord-015021-pol2qm74 7160 24 the the DT cord-015021-pol2qm74 7160 25 occurance occurance NN cord-015021-pol2qm74 7160 26 of of IN cord-015021-pol2qm74 7160 27 infectious infectious JJ cord-015021-pol2qm74 7160 28 and and CC cord-015021-pol2qm74 7160 29 wound wound JJ cord-015021-pol2qm74 7160 30 complications complication NNS cord-015021-pol2qm74 7160 31 has have VBZ cord-015021-pol2qm74 7160 32 been be VBN cord-015021-pol2qm74 7160 33 observed observe VBN cord-015021-pol2qm74 7160 34 between between IN cord-015021-pol2qm74 7160 35 the the DT cord-015021-pol2qm74 7160 36 two two CD cord-015021-pol2qm74 7160 37 groups group NNS cord-015021-pol2qm74 7160 38 . . . cord-015021-pol2qm74 7161 1 However however RB cord-015021-pol2qm74 7161 2 , , , cord-015021-pol2qm74 7161 3 the the DT cord-015021-pol2qm74 7161 4 APACHE APACHE NNP cord-015021-pol2qm74 7161 5 II II NNP cord-015021-pol2qm74 7161 6 score score NN cord-015021-pol2qm74 7161 7 indicated indicate VBD cord-015021-pol2qm74 7161 8 a a DT cord-015021-pol2qm74 7161 9 significantly significantly RB cord-015021-pol2qm74 7161 10 improved improve VBN cord-015021-pol2qm74 7161 11 clinical clinical JJ cord-015021-pol2qm74 7161 12 outcome outcome NN cord-015021-pol2qm74 7161 13 in in IN cord-015021-pol2qm74 7161 14 patients patient NNS cord-015021-pol2qm74 7161 15 with with IN cord-015021-pol2qm74 7161 16 supplemented supplement VBN cord-015021-pol2qm74 7161 17 diet diet NN cord-015021-pol2qm74 7161 18 . . . cord-015021-pol2qm74 7162 1 In in IN cord-015021-pol2qm74 7162 2 conclusion conclusion NN cord-015021-pol2qm74 7162 3 , , , cord-015021-pol2qm74 7162 4 early early JJ cord-015021-pol2qm74 7162 5 enteral enteral JJ cord-015021-pol2qm74 7162 6 nutrition nutrition NN cord-015021-pol2qm74 7162 7 with with IN cord-015021-pol2qm74 7162 8 an an DT cord-015021-pol2qm74 7162 9 arginine arginine NN cord-015021-pol2qm74 7162 10 , , , cord-015021-pol2qm74 7162 11 omega-3 omega-3 JJ cord-015021-pol2qm74 7162 12 fatty fatty JJ cord-015021-pol2qm74 7162 13 acids acid NNS cord-015021-pol2qm74 7162 14 and and CC cord-015021-pol2qm74 7162 15 RNA RNA NNP cord-015021-pol2qm74 7162 16 supplemented supplement VBD cord-015021-pol2qm74 7162 17 diet diet NN cord-015021-pol2qm74 7162 18 helps help VBZ cord-015021-pol2qm74 7162 19 to to TO cord-015021-pol2qm74 7162 20 recover recover VB cord-015021-pol2qm74 7162 21 more more RBR cord-015021-pol2qm74 7162 22 rapidly rapidly RB cord-015021-pol2qm74 7162 23 after after IN cord-015021-pol2qm74 7162 24 surgical surgical JJ cord-015021-pol2qm74 7162 25 Total total JJ cord-015021-pol2qm74 7162 26 parenteral parenteral JJ cord-015021-pol2qm74 7162 27 nutrition nutrition NN cord-015021-pol2qm74 7163 1 ( ( -LRB- cord-015021-pol2qm74 7163 2 TPN TPN NNP cord-015021-pol2qm74 7163 3 } } -RRB- cord-015021-pol2qm74 7163 4 is be VBZ cord-015021-pol2qm74 7163 5 associated associate VBN cord-015021-pol2qm74 7163 6 with with IN cord-015021-pol2qm74 7163 7 intestinal intestinal JJ cord-015021-pol2qm74 7163 8 atrophy atrophy NN cord-015021-pol2qm74 7163 9 and and CC cord-015021-pol2qm74 7163 10 dysfunction dysfunction NN cord-015021-pol2qm74 7163 11 attributed attribute VBN cord-015021-pol2qm74 7163 12 to to IN cord-015021-pol2qm74 7163 13 the the DT cord-015021-pol2qm74 7163 14 absence absence NN cord-015021-pol2qm74 7163 15 of of IN cord-015021-pol2qm74 7163 16 the the DT cord-015021-pol2qm74 7163 17 non non JJ cord-015021-pol2qm74 7163 18 - - JJ cord-015021-pol2qm74 7163 19 essential essential JJ cord-015021-pol2qm74 7163 20 amino amino NN cord-015021-pol2qm74 7163 21 acid acid NN cord-015021-pol2qm74 7163 22 glutamine glutamine NN cord-015021-pol2qm74 7163 23 in in IN cord-015021-pol2qm74 7163 24 current current JJ cord-015021-pol2qm74 7163 25 parenteral parenteral JJ cord-015021-pol2qm74 7163 26 nutrition nutrition NN cord-015021-pol2qm74 7163 27 solutions solution NNS cord-015021-pol2qm74 7163 28 . . . cord-015021-pol2qm74 7164 1 In in IN cord-015021-pol2qm74 7164 2 this this DT cord-015021-pol2qm74 7164 3 animal animal NN cord-015021-pol2qm74 7164 4 study study NN cord-015021-pol2qm74 7164 5 with with IN cord-015021-pol2qm74 7164 6 18 18 CD cord-015021-pol2qm74 7164 7 male male JJ cord-015021-pol2qm74 7164 8 Wistar Wistar NNP cord-015021-pol2qm74 7164 9 - - HYPH cord-015021-pol2qm74 7164 10 rats rat NNS cord-015021-pol2qm74 7164 11 we -PRON- PRP cord-015021-pol2qm74 7164 12 tested test VBD cord-015021-pol2qm74 7164 13 the the DT cord-015021-pol2qm74 7164 14 hypothesis hypothesis NN cord-015021-pol2qm74 7164 15 that that IN cord-015021-pol2qm74 7164 16 glutamine glutamine NN cord-015021-pol2qm74 7164 17 - - HYPH cord-015021-pol2qm74 7164 18 dipeptide dipeptide NN cord-015021-pol2qm74 7164 19 supplementation supplementation NN cord-015021-pol2qm74 7164 20 during during IN cord-015021-pol2qm74 7164 21 TPN TPN NNP cord-015021-pol2qm74 7164 22 for for IN cord-015021-pol2qm74 7164 23 10 10 CD cord-015021-pol2qm74 7164 24 days day NNS cord-015021-pol2qm74 7164 25 would would MD cord-015021-pol2qm74 7164 26 restore restore VB cord-015021-pol2qm74 7164 27 small small JJ cord-015021-pol2qm74 7164 28 bowel bowel NN cord-015021-pol2qm74 7164 29 atrophy atrophy NN cord-015021-pol2qm74 7164 30 and and CC cord-015021-pol2qm74 7164 31 TPN TPN NNP cord-015021-pol2qm74 7164 32 induced induce VBN cord-015021-pol2qm74 7164 33 dysfunction dysfunction NN cord-015021-pol2qm74 7164 34 . . . cord-015021-pol2qm74 7165 1 A a DT cord-015021-pol2qm74 7165 2 conventional conventional JJ cord-015021-pol2qm74 7165 3 TPN TPN NNP cord-015021-pol2qm74 7165 4 solution solution NN cord-015021-pol2qm74 7165 5 ( ( -LRB- cord-015021-pol2qm74 7165 6 250 250 CD cord-015021-pol2qm74 7165 7 Kcai Kcai NNP cord-015021-pol2qm74 7165 8 / / SYM cord-015021-pol2qm74 7165 9 kg kg NNP cord-015021-pol2qm74 7165 10 bw bw NNP cord-015021-pol2qm74 7165 11 ) ) -RRB- cord-015021-pol2qm74 7165 12 was be VBD cord-015021-pol2qm74 7165 13 compared compare VBN cord-015021-pol2qm74 7165 14 to to IN cord-015021-pol2qm74 7165 15 an an DT cord-015021-pol2qm74 7165 16 isocaloric isocaloric JJ cord-015021-pol2qm74 7165 17 and and CC cord-015021-pol2qm74 7165 18 isonitrogenous isonitrogenous JJ cord-015021-pol2qm74 7165 19 TPN TPN NNP cord-015021-pol2qm74 7165 20 ( ( -LRB- cord-015021-pol2qm74 7165 21 0,5 0,5 CD cord-015021-pol2qm74 7165 22 g g NN cord-015021-pol2qm74 7165 23 N N NNP cord-015021-pol2qm74 7165 24 / / SYM cord-015021-pol2qm74 7165 25 animal animal NN cord-015021-pol2qm74 7165 26 / / SYM cord-015021-pol2qm74 7165 27 d d NN cord-015021-pol2qm74 7165 28 ) ) -RRB- cord-015021-pol2qm74 7165 29 supplemented supplement VBN cord-015021-pol2qm74 7165 30 with with IN cord-015021-pol2qm74 7165 31 alanin alanin NNS cord-015021-pol2qm74 7165 32 - - HYPH cord-015021-pol2qm74 7165 33 glutamin glutamin NNP cord-015021-pol2qm74 7165 34 ( ( -LRB- cord-015021-pol2qm74 7165 35 Ala ala NN cord-015021-pol2qm74 7165 36 - - HYPH cord-015021-pol2qm74 7165 37 GIn GIn NNS cord-015021-pol2qm74 7165 38 ) ) -RRB- cord-015021-pol2qm74 7165 39 dipeptide dipeptide NNP cord-015021-pol2qm74 7165 40 ( ( -LRB- cord-015021-pol2qm74 7165 41 0,15 0,15 NNP cord-015021-pol2qm74 7165 42 g g NNP cord-015021-pol2qm74 7165 43 N n CD cord-015021-pol2qm74 7165 44 derived derive VBN cord-015021-pol2qm74 7165 45 from from IN cord-015021-pol2qm74 7165 46 Ala Ala NNP cord-015021-pol2qm74 7165 47 - - HYPH cord-015021-pol2qm74 7165 48 GIn GIn NNS cord-015021-pol2qm74 7165 49 = = SYM cord-015021-pol2qm74 7165 50 30 30 CD cord-015021-pol2qm74 7165 51 % % NN cord-015021-pol2qm74 7165 52 GIn GIn NNS cord-015021-pol2qm74 7165 53 - - HYPH cord-015021-pol2qm74 7165 54 N N NNP cord-015021-pol2qm74 7165 55 ) ) -RRB- cord-015021-pol2qm74 7165 56 . . . cord-015021-pol2qm74 7166 1 An an DT cord-015021-pol2qm74 7166 2 enteral enteral NN cord-015021-pol2qm74 7166 3 fed fed NNP cord-015021-pol2qm74 7166 4 cqntrol cqntrol NNP cord-015021-pol2qm74 7166 5 group group NNP cord-015021-pol2qm74 7166 6 was be VBD cord-015021-pol2qm74 7166 7 included include VBN cord-015021-pol2qm74 7166 8 . . . cord-015021-pol2qm74 7167 1 Mucosal Mucosal NNP cord-015021-pol2qm74 7167 2 thickness thickness NN cord-015021-pol2qm74 7167 3 , , , cord-015021-pol2qm74 7167 4 villous villous NNP cord-015021-pol2qm74 7167 5 height height NN cord-015021-pol2qm74 7167 6 and and CC cord-015021-pol2qm74 7167 7 architecture architecture NN cord-015021-pol2qm74 7167 8 , , , cord-015021-pol2qm74 7167 9 absorption absorption NN cord-015021-pol2qm74 7167 10 of of IN cord-015021-pol2qm74 7167 11 water water NN cord-015021-pol2qm74 7167 12 and and CC cord-015021-pol2qm74 7167 13 glucose glucose NN cord-015021-pol2qm74 7167 14 as as RB cord-015021-pol2qm74 7167 15 well well RB cord-015021-pol2qm74 7167 16 as as IN cord-015021-pol2qm74 7167 17 dissacharidase dissacharidase NN cord-015021-pol2qm74 7167 18 activity activity NN cord-015021-pol2qm74 7167 19 of of IN cord-015021-pol2qm74 7167 20 maltase maltase NN cord-015021-pol2qm74 7167 21 and and CC cord-015021-pol2qm74 7167 22 alkaline alkaline JJ cord-015021-pol2qm74 7167 23 phosphatase phosphatase NN cord-015021-pol2qm74 7167 24 were be VBD cord-015021-pol2qm74 7167 25 evaluated evaluate VBN cord-015021-pol2qm74 7167 26 . . . cord-015021-pol2qm74 7168 1 Total total JJ cord-015021-pol2qm74 7168 2 parenteral parenteral JJ cord-015021-pol2qm74 7168 3 nutrition nutrition NN cord-015021-pol2qm74 7168 4 in in IN cord-015021-pol2qm74 7168 5 rats rat NNS cord-015021-pol2qm74 7168 6 causes cause VBZ cord-015021-pol2qm74 7168 7 villous villous NNP cord-015021-pol2qm74 7168 8 atrophy atrophy NN cord-015021-pol2qm74 7168 9 , , , cord-015021-pol2qm74 7168 10 a a DT cord-015021-pol2qm74 7168 11 significantly significantly RB cord-015021-pol2qm74 7168 12 reduced reduce VBN cord-015021-pol2qm74 7168 13 absorption absorption NN cord-015021-pol2qm74 7168 14 rate rate NN cord-015021-pol2qm74 7168 15 and and CC cord-015021-pol2qm74 7168 16 a a DT cord-015021-pol2qm74 7168 17 decreased decreased JJ cord-015021-pol2qm74 7168 18 activity activity NN cord-015021-pol2qm74 7168 19 of of IN cord-015021-pol2qm74 7168 20 villous villous NNP cord-015021-pol2qm74 7168 21 enzymes enzyme NNS cord-015021-pol2qm74 7168 22 compared compare VBN cord-015021-pol2qm74 7168 23 to to IN cord-015021-pol2qm74 7168 24 an an DT cord-015021-pol2qm74 7168 25 enteral enteral NN cord-015021-pol2qm74 7168 26 fed feed VBN cord-015021-pol2qm74 7168 27 control control NN cord-015021-pol2qm74 7168 28 ( ( -LRB- cord-015021-pol2qm74 7168 29 p p NN cord-015021-pol2qm74 7168 30 < < XX cord-015021-pol2qm74 7168 31 O,01 O,01 NNP cord-015021-pol2qm74 7168 32 ) ) -RRB- cord-015021-pol2qm74 7168 33 . . . cord-015021-pol2qm74 7169 1 Addition addition NN cord-015021-pol2qm74 7169 2 of of IN cord-015021-pol2qm74 7169 3 Ala Ala NNP cord-015021-pol2qm74 7169 4 - - : cord-015021-pol2qm74 7169 5 GIn GIn NNS cord-015021-pol2qm74 7169 6 to to IN cord-015021-pol2qm74 7169 7 parenteral parenteral JJ cord-015021-pol2qm74 7169 8 nutrition nutrition NN cord-015021-pol2qm74 7169 9 solutions solution NNS cord-015021-pol2qm74 7169 10 prevents prevent VBZ cord-015021-pol2qm74 7169 11 intestinal intestinal JJ cord-015021-pol2qm74 7169 12 atrophy atrophy NN cord-015021-pol2qm74 7169 13 and and CC cord-015021-pol2qm74 7169 14 restores restore VBZ cord-015021-pol2qm74 7169 15 functional functional JJ cord-015021-pol2qm74 7169 16 alterations alteration NNS cord-015021-pol2qm74 7169 17 with with IN cord-015021-pol2qm74 7169 18 a a DT cord-015021-pol2qm74 7169 19 significantly significantly RB cord-015021-pol2qm74 7169 20 increased increase VBN cord-015021-pol2qm74 7169 21 rate rate NN cord-015021-pol2qm74 7169 22 of of IN cord-015021-pol2qm74 7169 23 water water NN cord-015021-pol2qm74 7169 24 and and CC cord-015021-pol2qm74 7169 25 glucose glucose NN cord-015021-pol2qm74 7169 26 absorption absorption NN cord-015021-pol2qm74 7169 27 as as RB cord-015021-pol2qm74 7169 28 well well RB cord-015021-pol2qm74 7169 29 as as IN cord-015021-pol2qm74 7169 30 a a DT cord-015021-pol2qm74 7169 31 higher high JJR cord-015021-pol2qm74 7169 32 dissacharidase dissacharidase NN cord-015021-pol2qm74 7169 33 activity activity NN cord-015021-pol2qm74 7169 34 compared compare VBN cord-015021-pol2qm74 7169 35 to to IN cord-015021-pol2qm74 7169 36 the the DT cord-015021-pol2qm74 7169 37 standard standard JJ cord-015021-pol2qm74 7169 38 TPN TPN NNP cord-015021-pol2qm74 7169 39 group group NN cord-015021-pol2qm74 7169 40 ( ( -LRB- cord-015021-pol2qm74 7169 41 p<0,01 p<0,01 NN cord-015021-pol2qm74 7169 42 ) ) -RRB- cord-015021-pol2qm74 7169 43 . . . cord-015021-pol2qm74 7170 1 There there EX cord-015021-pol2qm74 7170 2 was be VBD cord-015021-pol2qm74 7170 3 no no DT cord-015021-pol2qm74 7170 4 significant significant JJ cord-015021-pol2qm74 7170 5 difference difference NN cord-015021-pol2qm74 7170 6 found find VBN cord-015021-pol2qm74 7170 7 between between IN cord-015021-pol2qm74 7170 8 the the DT cord-015021-pol2qm74 7170 9 enteral enteral NN cord-015021-pol2qm74 7170 10 fed feed VBN cord-015021-pol2qm74 7170 11 control control NN cord-015021-pol2qm74 7170 12 and and CC cord-015021-pol2qm74 7170 13 the the DT cord-015021-pol2qm74 7170 14 dipeptide dipeptide NN cord-015021-pol2qm74 7170 15 supplemented supplement VBD cord-015021-pol2qm74 7170 16 animals animal NNS cord-015021-pol2qm74 7170 17 concerning concern VBG cord-015021-pol2qm74 7170 18 intestinal intestinal JJ cord-015021-pol2qm74 7170 19 structure structure NN cord-015021-pol2qm74 7170 20 and and CC cord-015021-pol2qm74 7170 21 absorption absorption NN cord-015021-pol2qm74 7170 22 , , , cord-015021-pol2qm74 7170 23 The the DT cord-015021-pol2qm74 7170 24 enzyme enzyme NN cord-015021-pol2qm74 7170 25 activity activity NN cord-015021-pol2qm74 7170 26 was be VBD cord-015021-pol2qm74 7170 27 significantly significantly RB cord-015021-pol2qm74 7170 28 decreased decrease VBN cord-015021-pol2qm74 7170 29 in in IN cord-015021-pol2qm74 7170 30 the the DT cord-015021-pol2qm74 7170 31 Ala Ala NNP cord-015021-pol2qm74 7170 32 - - HYPH cord-015021-pol2qm74 7170 33 GIn GIn NNS cord-015021-pol2qm74 7170 34 supplemented supplement VBD cord-015021-pol2qm74 7170 35 group group NN cord-015021-pol2qm74 7170 36 compared compare VBN cord-015021-pol2qm74 7170 37 to to IN cord-015021-pol2qm74 7170 38 the the DT cord-015021-pol2qm74 7170 39 enteral enteral NN cord-015021-pol2qm74 7170 40 fed feed VBN cord-015021-pol2qm74 7170 41 control control NN cord-015021-pol2qm74 7170 42 ( ( -LRB- cord-015021-pol2qm74 7170 43 p<0,01 p<0,01 NN cord-015021-pol2qm74 7170 44 ) ) -RRB- cord-015021-pol2qm74 7170 45 . . . cord-015021-pol2qm74 7171 1 In in IN cord-015021-pol2qm74 7171 2 this this DT cord-015021-pol2qm74 7171 3 rat rat NN cord-015021-pol2qm74 7171 4 model model NN cord-015021-pol2qm74 7171 5 supplementation supplementation NN cord-015021-pol2qm74 7171 6 of of IN cord-015021-pol2qm74 7171 7 parentera parentera NNP cord-015021-pol2qm74 7171 8 ] ] -RRB- cord-015021-pol2qm74 7171 9 nutrition nutrition NN cord-015021-pol2qm74 7171 10 solutions solution NNS cord-015021-pol2qm74 7171 11 with with IN cord-015021-pol2qm74 7171 12 Ala Ala NNP cord-015021-pol2qm74 7171 13 - - HYPH cord-015021-pol2qm74 7171 14 GIn gin NN cord-015021-pol2qm74 7171 15 dipeptide dipeptide NN cord-015021-pol2qm74 7171 16 restores restore VBZ cord-015021-pol2qm74 7171 17 TPN TPN NNP cord-015021-pol2qm74 7171 18 induced induce VBD cord-015021-pol2qm74 7171 19 intestinal intestinal JJ cord-015021-pol2qm74 7171 20 atrophy atrophy NN cord-015021-pol2qm74 7171 21 and and CC cord-015021-pol2qm74 7171 22 dysfunction dysfunction NN cord-015021-pol2qm74 7171 23 . . . cord-015021-pol2qm74 7172 1 Boston Boston NNP cord-015021-pol2qm74 7172 2 . . . cord-015021-pol2qm74 7173 1 ~ ~ NFP cord-015021-pol2qm74 7173 2 USA USA NNP cord-015021-pol2qm74 7173 3 Injury Injury NNP cord-015021-pol2qm74 7173 4 , , , cord-015021-pol2qm74 7173 5 infection infection NN cord-015021-pol2qm74 7173 6 and and CC cord-015021-pol2qm74 7173 7 major major JJ cord-015021-pol2qm74 7173 8 o1~'ations o1~'ation NNS cord-015021-pol2qm74 7173 9 s s NN cord-015021-pol2qm74 7173 10 ~ ~ NFP cord-015021-pol2qm74 7173 11 nulate nulate NN cord-015021-pol2qm74 7173 12 a a DT cord-015021-pol2qm74 7173 13 variety variety NN cord-015021-pol2qm74 7173 14 of of IN cord-015021-pol2qm74 7173 15 factors factor NNS cord-015021-pol2qm74 7173 16 whi~ whi~ CD cord-015021-pol2qm74 7173 17 initiate initiate VBP cord-015021-pol2qm74 7173 18 the the DT cord-015021-pol2qm74 7173 19 body body NN cord-015021-pol2qm74 7173 20 's 's POS cord-015021-pol2qm74 7173 21 response response NN cord-015021-pol2qm74 7173 22 to to IN cord-015021-pol2qm74 7173 23 th~ th~ NNP cord-015021-pol2qm74 7173 24 st~ st~ NNP cord-015021-pol2qm74 7173 25 .. .. . cord-015021-pol2qm74 7174 1 sses sses NNP cord-015021-pol2qm74 7174 2 . . . cord-015021-pol2qm74 7174 3 ' ' '' cord-015021-pol2qm74 7175 1 i"hese i"hese JJ cord-015021-pol2qm74 7175 2 reactions reaction NNS cord-015021-pol2qm74 7175 3 are be VBP cord-015021-pol2qm74 7175 4 m m NNP cord-015021-pol2qm74 7175 5 ~ ~ CD cord-015021-pol2qm74 7175 6 liated liate VBN cord-015021-pol2qm74 7175 7 by by IN cord-015021-pol2qm74 7175 8 a a DT cord-015021-pol2qm74 7175 9 cbmage cbmage NN cord-015021-pol2qm74 7175 10 ia ia NNP cord-015021-pol2qm74 7176 1 the the DT cord-015021-pol2qm74 7176 2 neta'al neta'al NNP cord-015021-pol2qm74 7176 3 hormonal hormonal JJ cord-015021-pol2qm74 7176 4 , , , cord-015021-pol2qm74 7176 5 eaC.ranmEmt eac.ranmemt ADD cord-015021-pol2qm74 7176 6 , , , cord-015021-pol2qm74 7176 7 by by IN cord-015021-pol2qm74 7176 8 the the DT cord-015021-pol2qm74 7176 9 elaboration elaboration NN cord-015021-pol2qm74 7176 10 of of IN cord-015021-pol2qm74 7176 11 eytokines eytokines NNP cord-015021-pol2qm74 7176 12 and and CC cord-015021-pol2qm74 7176 13 tl tl NNP cord-015021-pol2qm74 7176 14 ~ ~ NNP cord-015021-pol2qm74 7176 15 ougb ougb NNP cord-015021-pol2qm74 7176 16 the the DT cord-015021-pol2qm74 7176 17 stimu stimu NNP cord-015021-pol2qm74 7176 18 / / SYM cord-015021-pol2qm74 7176 19 ation ation NN cord-015021-pol2qm74 7176 20 of of IN cord-015021-pol2qm74 7176 21 other other JJ cord-015021-pol2qm74 7176 22 inflammatory inflammatory JJ cord-015021-pol2qm74 7176 23 mediators mediator NNS cord-015021-pol2qm74 7176 24 . . . cord-015021-pol2qm74 7177 1 This this DT cord-015021-pol2qm74 7177 2 eatabolio eatabolio NN cord-015021-pol2qm74 7177 3 setting set VBG cord-015021-pol2qm74 7177 4 zesulis zesulis NNP cord-015021-pol2qm74 7177 5 in in IN cord-015021-pol2qm74 7177 6 body body NN cord-015021-pol2qm74 7177 7 protein protein NN cord-015021-pol2qm74 7177 8 loss loss NN cord-015021-pol2qm74 7177 9 , , , cord-015021-pol2qm74 7177 10 which which WDT cord-015021-pol2qm74 7177 11 g g NN cord-015021-pol2qm74 7177 12 - - HYPH cord-015021-pol2qm74 7177 13 taduaI1y taduaI1y NNP cord-015021-pol2qm74 7177 14 erodes erode VBZ cord-015021-pol2qm74 7177 15 both both CC cord-015021-pol2qm74 7177 16 fimetianal fimetianal JJ cord-015021-pol2qm74 7177 17 and and CC cord-015021-pol2qm74 7177 18 stm~ stm~ CD cord-015021-pol2qm74 7177 19 tissue tissue NN cord-015021-pol2qm74 7177 20 . . . cord-015021-pol2qm74 7178 1 Wiu3_B Wiu3_B NNP cord-015021-pol2qm74 7179 1 the the DT cord-015021-pol2qm74 7179 2 normally normally RB cord-015021-pol2qm74 7179 3 nom'ished nom'ishe VBN cord-015021-pol2qm74 7179 4 individual individual NN cord-015021-pol2qm74 7179 5 can can MD cord-015021-pol2qm74 7179 6 withslzod withslzod VB cord-015021-pol2qm74 7179 7 " " `` cord-015021-pol2qm74 7179 8 d~ d~ NNP cord-015021-pol2qm74 7179 9 response response NN cord-015021-pol2qm74 7179 10 for for IN cord-015021-pol2qm74 7179 11 a a DT cord-015021-pol2qm74 7179 12 brief brief JJ cord-015021-pol2qm74 7179 13 period period NN cord-015021-pol2qm74 7179 14 of of IN cord-015021-pol2qm74 7179 15 time time NN cord-015021-pol2qm74 7179 16 , , , cord-015021-pol2qm74 7179 17 Ircolonged Ircolonged NNP cord-015021-pol2qm74 7179 18 eatabolLsm eatabolLsm NNP cord-015021-pol2qm74 7179 19 L~ L~ NNP cord-015021-pol2qm74 7179 20 associated associate VBD cord-015021-pol2qm74 7179 21 with with IN cord-015021-pol2qm74 7179 22 ~,nmunosuppmssion ~,nmunosuppmssion NN cord-015021-pol2qm74 7179 23 , , , cord-015021-pol2qm74 7179 24 poor poor JJ cord-015021-pol2qm74 7179 25 wound wound NN cord-015021-pol2qm74 7179 26 healing healing NN cord-015021-pol2qm74 7179 27 , , , cord-015021-pol2qm74 7179 28 and and CC cord-015021-pol2qm74 7179 29 proioagcd proioagcd NN cord-015021-pol2qm74 7179 30 convalescence convalescence NN cord-015021-pol2qm74 7179 31 . . . cord-015021-pol2qm74 7180 1 Surgeons surgeon NNS cord-015021-pol2qm74 7180 2 have have VBP cord-015021-pol2qm74 7180 3 reJ2ed rej2ed NN cord-015021-pol2qm74 7180 4 on on IN cord-015021-pol2qm74 7180 5 intraveaous intraveaous JJ cord-015021-pol2qm74 7180 6 or or CC cord-015021-pol2qm74 7180 7 eater~ eater~ NNP cord-015021-pol2qm74 7180 8 feedings feeding NNS cord-015021-pol2qm74 7181 1 to to IN cord-015021-pol2qm74 7181 2 ~everse ~everse NFP cord-015021-pol2qm74 7181 3 this this DT cord-015021-pol2qm74 7181 4 process process NN cord-015021-pol2qm74 7181 5 . . . cord-015021-pol2qm74 7182 1 A a DT cord-015021-pol2qm74 7182 2 va va NNP cord-015021-pol2qm74 7182 3 ~ ~ NFP cord-015021-pol2qm74 7182 4 ety ety NNP cord-015021-pol2qm74 7182 5 of of IN cord-015021-pol2qm74 7182 6 data datum NNS cord-015021-pol2qm74 7182 7 now now RB cord-015021-pol2qm74 7182 8 indicates indicate VBZ cord-015021-pol2qm74 7182 9 that that IN cord-015021-pol2qm74 7182 10 it -PRON- PRP cord-015021-pol2qm74 7182 11 is be VBZ cord-015021-pol2qm74 7182 12 extremely extremely RB cord-015021-pol2qm74 7182 13 di di NNP cord-015021-pol2qm74 7182 14 ~ ~ NFP cord-015021-pol2qm74 7182 15 edt edt NNP cord-015021-pol2qm74 7182 16 to to IN cord-015021-pol2qm74 7183 1 replete replete JJ cord-015021-pol2qm74 7183 2 protein protein NN cord-015021-pol2qm74 7183 3 - - HYPH cord-015021-pol2qm74 7183 4 containing contain VBG cord-015021-pol2qm74 7183 5 tissue tissue NN cord-015021-pol2qm74 7183 6 d d NN cord-015021-pol2qm74 7184 1 ~g ~g NFP cord-015021-pol2qm74 7184 2 the the DT cord-015021-pol2qm74 7184 3 eataholie eataholie NNP cord-015021-pol2qm74 7184 4 state state NN cord-015021-pol2qm74 7184 5 of of IN cord-015021-pol2qm74 7184 6 illness illness NN cord-015021-pol2qm74 7184 7 ; ; : cord-015021-pol2qm74 7184 8 the the DT cord-015021-pol2qm74 7184 9 umutt umutt NNP cord-015021-pol2qm74 7184 10 response response NN cord-015021-pol2qm74 7184 11 to to IN cord-015021-pol2qm74 7184 12 hypercaloiSe hypercaloise CD cord-015021-pol2qm74 7184 13 feedings feeding NNS cord-015021-pol2qm74 7184 14 in in IN cord-015021-pol2qm74 7184 15 this this DT cord-015021-pol2qm74 7184 16 setting setting NN cord-015021-pol2qm74 7184 17 is be VBZ cord-015021-pol2qm74 7184 18 the the DT cord-015021-pol2qm74 7184 19 incxeased incxeased JJ cord-015021-pol2qm74 7184 20 accretion accretion NN cord-015021-pol2qm74 7184 21 of of IN cord-015021-pol2qm74 7184 22 body body NN cord-015021-pol2qm74 7184 23 fat fat NN cord-015021-pol2qm74 7184 24 md md NNP cord-015021-pol2qm74 7184 25 water water NN cord-015021-pol2qm74 7184 26 . . . cord-015021-pol2qm74 7185 1 Administration Administration NNP cord-015021-pol2qm74 7185 2 of of IN cord-015021-pol2qm74 7185 3 gxow~ gxow~ NNP cord-015021-pol2qm74 7185 4 ho ho NNP cord-015021-pol2qm74 7186 1 ~moae ~moae NNP cord-015021-pol2qm74 7187 1 ~cesults ~cesults NNP cord-015021-pol2qm74 7187 2 i.a i.a NNP cord-015021-pol2qm74 7187 3 n n NNP cord-015021-pol2qm74 7187 4 shift shift NN cord-015021-pol2qm74 7187 5 of of IN cord-015021-pol2qm74 7187 6 the the DT cord-015021-pol2qm74 7187 7 body body NN cord-015021-pol2qm74 7187 8 's 's POS cord-015021-pol2qm74 7187 9 oxidative oxidative JJ cord-015021-pol2qm74 7187 10 machinery machinery NN cord-015021-pol2qm74 7187 11 to to TO cord-015021-pol2qm74 7187 12 fat fat VB cord-015021-pol2qm74 7187 13 rather rather RB cord-015021-pol2qm74 7187 14 than than IN cord-015021-pol2qm74 7187 15 eazbohydmte eazbohydmte NNP cord-015021-pol2qm74 7187 16 utiq utiq NNP cord-015021-pol2qm74 7187 17 ~ ~ NNP cord-015021-pol2qm74 7187 18 afic~ afic~ NNP cord-015021-pol2qm74 7187 19 ; ; : cord-015021-pol2qm74 7187 20 ¢oncomitaatiy ¢oncomitaatiy NNS cord-015021-pol2qm74 7187 21 , , , cord-015021-pol2qm74 7187 22 protein protein NN cord-015021-pol2qm74 7187 23 synthesis synthesis NN cord-015021-pol2qm74 7187 24 is be VBZ cord-015021-pol2qm74 7187 25 stimulated stimulate VBN cord-015021-pol2qm74 7187 26 . . . cord-015021-pol2qm74 7188 1 This this DT cord-015021-pol2qm74 7188 2 metabolic metabolic JJ cord-015021-pol2qm74 7188 3 state state NN cord-015021-pol2qm74 7188 4 may may MD cord-015021-pol2qm74 7188 5 have have VB cord-015021-pol2qm74 7188 6 clinical clinical JJ cord-015021-pol2qm74 7188 7 utility utility NN cord-015021-pol2qm74 7188 8 in in IN cord-015021-pol2qm74 7188 9 p p NN cord-015021-pol2qm74 7189 1 ~e.n.ts ~e.n.ts NFP cord-015021-pol2qm74 7189 2 who who WP cord-015021-pol2qm74 7189 3 need need VBP cord-015021-pol2qm74 7189 4 to to TO cord-015021-pol2qm74 7189 5 heal heal VB cord-015021-pol2qm74 7189 6 large large JJ cord-015021-pol2qm74 7189 7 wotmds wotmds NN cord-015021-pol2qm74 7189 8 , , , cord-015021-pol2qm74 7189 9 in in IN cord-015021-pol2qm74 7189 10 those those DT cord-015021-pol2qm74 7189 11 who who WP cord-015021-pol2qm74 7189 12 need need VBP cord-015021-pol2qm74 7189 13 to to TO cord-015021-pol2qm74 7189 14 gain gain VB cord-015021-pol2qm74 7189 15 strength strength NN cord-015021-pol2qm74 7189 16 in in IN cord-015021-pol2qm74 7189 17 order order NN cord-015021-pol2qm74 7189 18 to to TO cord-015021-pol2qm74 7189 19 be be VB cord-015021-pol2qm74 7189 20 w w NN cord-015021-pol2qm74 7189 21 ~ ~ NFP cord-015021-pol2qm74 7189 22 ed ed NN cord-015021-pol2qm74 7189 23 5ore 5ore CD cord-015021-pol2qm74 7189 24 veatilatory veatilatory NN cord-015021-pol2qm74 7189 25 support support NN cord-015021-pol2qm74 7189 26 , , , cord-015021-pol2qm74 7189 27 or or CC cord-015021-pol2qm74 7189 28 those those DT cord-015021-pol2qm74 7189 29 patients patient NNS cord-015021-pol2qm74 7189 30 who who WP cord-015021-pol2qm74 7190 1 ~ve ~ve NNP cord-015021-pol2qm74 7191 1 mulfiorgan mulfiorgan NNP cord-015021-pol2qm74 7191 2 failure failure NN cord-015021-pol2qm74 7191 3 and and CC cord-015021-pol2qm74 7191 4 nee~ nee~ NNP cord-015021-pol2qm74 7191 5 to to TO cord-015021-pol2qm74 7191 6 ealaaace ealaaace VB cord-015021-pol2qm74 7191 7 protein protein NN cord-015021-pol2qm74 7191 8 syatSesis syatsesis NN cord-015021-pol2qm74 7191 9 to to IN cord-015021-pol2qm74 7191 10 in.suze in.suze NNP cord-015021-pol2qm74 7191 11 recovery recovery NN cord-015021-pol2qm74 7191 12 . . . cord-015021-pol2qm74 7192 1 235als 235als CD cord-015021-pol2qm74 7192 2 are be VBP cord-015021-pol2qm74 7192 3 now now RB cord-015021-pol2qm74 7192 4 in in IN cord-015021-pol2qm74 7192 5 progress progress NN cord-015021-pol2qm74 7192 6 to to IN cord-015021-pol2qm74 7192 7 dcterm~ dcterm~ NN cord-015021-pol2qm74 7193 1 e e LS cord-015021-pol2qm74 7193 2 the the DT cord-015021-pol2qm74 7193 3 benefit benefit NN cord-015021-pol2qm74 7193 4 of of IN cord-015021-pol2qm74 7193 5 growth growth NN cord-015021-pol2qm74 7193 6 hormone hormone NN cord-015021-pol2qm74 7193 7 in in IN cord-015021-pol2qm74 7193 8 these these DT cord-015021-pol2qm74 7193 9 and and CC cord-015021-pol2qm74 7193 10 other other JJ cord-015021-pol2qm74 7193 11 disease disease NN cord-015021-pol2qm74 7193 12 state.s state.s NN cord-015021-pol2qm74 7193 13 , , , cord-015021-pol2qm74 7193 14 rn rn NN cord-015021-pol2qm74 7194 1 the the DT cord-015021-pol2qm74 7194 2 fature fature NNP cord-015021-pol2qm74 7194 3 , , , cord-015021-pol2qm74 7194 4 the the DT cord-015021-pol2qm74 7194 5 increased increase VBN cord-015021-pol2qm74 7194 6 use use NN cord-015021-pol2qm74 7194 7 of of IN cord-015021-pol2qm74 7194 8 growth growth NN cord-015021-pol2qm74 7194 9 hormone hormone NN cord-015021-pol2qm74 7194 10 , , , cord-015021-pol2qm74 7194 11 will will MD cord-015021-pol2qm74 7194 12 occur occur VB cord-015021-pol2qm74 7194 13 ; ; : cord-015021-pol2qm74 7194 14 , , , cord-015021-pol2qm74 7194 15 this this DT cord-015021-pol2qm74 7194 16 and and CC cord-015021-pol2qm74 7194 17 other other JJ cord-015021-pol2qm74 7194 18 growth growth NN cord-015021-pol2qm74 7194 19 factors factor NNS cord-015021-pol2qm74 7194 20 will will MD cord-015021-pol2qm74 7194 21 serve serve VB cord-015021-pol2qm74 7194 22 to to IN cord-015021-pol2qm74 7194 23 su~2po~ su~2po~ NNP cord-015021-pol2qm74 7194 24 the the DT cord-015021-pol2qm74 7194 25 host host NN cord-015021-pol2qm74 7194 26 and and CC cord-015021-pol2qm74 7194 27 shorten shorten VB cord-015021-pol2qm74 7194 28 convalesceace convalesceace NN cord-015021-pol2qm74 7194 29 following follow VBG cord-015021-pol2qm74 7194 30 catabolic catabolic JJ cord-015021-pol2qm74 7194 31 diseases disease NNS cord-015021-pol2qm74 7194 32 . . . cord-015021-pol2qm74 7195 1 Our -PRON- PRP$ cord-015021-pol2qm74 7195 2 objective objective NN cord-015021-pol2qm74 7195 3 was be VBD cord-015021-pol2qm74 7195 4 to to TO cord-015021-pol2qm74 7195 5 study study VB cord-015021-pol2qm74 7195 6 effects effect NNS cord-015021-pol2qm74 7195 7 of of IN cord-015021-pol2qm74 7195 8 pre pre JJ cord-015021-pol2qm74 7195 9 - - JJ cord-015021-pol2qm74 7195 10 trauma trauma JJ cord-015021-pol2qm74 7195 11 growth growth NN cord-015021-pol2qm74 7195 12 hormone hormone NN cord-015021-pol2qm74 7195 13 ( ( -LRB- cord-015021-pol2qm74 7195 14 GH gh NN cord-015021-pol2qm74 7195 15 ) ) -RRB- cord-015021-pol2qm74 7195 16 treatment treatment NN cord-015021-pol2qm74 7195 17 on on IN cord-015021-pol2qm74 7195 18 liver liver NN cord-015021-pol2qm74 7195 19 and and CC cord-015021-pol2qm74 7195 20 skeletal skeletal JJ cord-015021-pol2qm74 7195 21 muscle muscle NN cord-015021-pol2qm74 7195 22 metabolism metabolism NN cord-015021-pol2qm74 7195 23 in in IN cord-015021-pol2qm74 7195 24 a a DT cord-015021-pol2qm74 7195 25 trauma trauma NN cord-015021-pol2qm74 7195 26 model model NN cord-015021-pol2qm74 7195 27 in in IN cord-015021-pol2qm74 7195 28 piglets piglet NNS cord-015021-pol2qm74 7195 29 . . . cord-015021-pol2qm74 7196 1 Twenty twenty CD cord-015021-pol2qm74 7196 2 - - HYPH cord-015021-pol2qm74 7196 3 four four CD cord-015021-pol2qm74 7196 4 piglets piglet NNS cord-015021-pol2qm74 7196 5 were be VBD cord-015021-pol2qm74 7196 6 randomized randomize VBN cord-015021-pol2qm74 7196 7 to to IN cord-015021-pol2qm74 7196 8 three three CD cord-015021-pol2qm74 7196 9 treatment treatment NN cord-015021-pol2qm74 7196 10 groups group NNS cord-015021-pol2qm74 7196 11 ; ; : cord-015021-pol2qm74 7196 12 one one CD cord-015021-pol2qm74 7196 13 group group NN cord-015021-pol2qm74 7196 14 was be VBD cord-015021-pol2qm74 7196 15 pretreated pretreate VBN cord-015021-pol2qm74 7196 16 with with IN cord-015021-pol2qm74 7196 17 GH GH NNP cord-015021-pol2qm74 7196 18 24 24 CD cord-015021-pol2qm74 7196 19 IU IU NNP cord-015021-pol2qm74 7196 20 daily daily RB cord-015021-pol2qm74 7196 21 three three CD cord-015021-pol2qm74 7196 22 days day NNS cord-015021-pol2qm74 7196 23 before before IN cord-015021-pol2qm74 7196 24 the the DT cord-015021-pol2qm74 7196 25 experiment experiment NN cord-015021-pol2qm74 7196 26 ( ( -LRB- cord-015021-pol2qm74 7196 27 GH-3 GH-3 NNP cord-015021-pol2qm74 7196 28 ) ) -RRB- cord-015021-pol2qm74 7196 29 , , , cord-015021-pol2qm74 7196 30 another another DT cord-015021-pol2qm74 7196 31 group group NN cord-015021-pol2qm74 7196 32 treated treat VBN cord-015021-pol2qm74 7196 33 with with IN cord-015021-pol2qm74 7196 34 GH GH NNP cord-015021-pol2qm74 7196 35 24 24 CD cord-015021-pol2qm74 7196 36 IE IE NNP cord-015021-pol2qm74 7196 37 at at IN cord-015021-pol2qm74 7196 38 the the DT cord-015021-pol2qm74 7196 39 start start NN cord-015021-pol2qm74 7196 40 of of IN cord-015021-pol2qm74 7196 41 the the DT cord-015021-pol2qm74 7196 42 surgical surgical JJ cord-015021-pol2qm74 7196 43 procedure procedure NN cord-015021-pol2qm74 7196 44 ( ( -LRB- cord-015021-pol2qm74 7196 45 GH-1 GH-1 NNP cord-015021-pol2qm74 7196 46 ) ) -RRB- cord-015021-pol2qm74 7196 47 and and CC cord-015021-pol2qm74 7196 48 one one CD cord-015021-pol2qm74 7196 49 group group NN cord-015021-pol2qm74 7196 50 served serve VBD cord-015021-pol2qm74 7196 51 as as IN cord-015021-pol2qm74 7196 52 untreated untreated JJ cord-015021-pol2qm74 7196 53 controls control NNS cord-015021-pol2qm74 7196 54 ( ( -LRB- cord-015021-pol2qm74 7196 55 CON con NN cord-015021-pol2qm74 7196 56 ) ) -RRB- cord-015021-pol2qm74 7196 57 . . . cord-015021-pol2qm74 7197 1 They -PRON- PRP cord-015021-pol2qm74 7197 2 underwent undergo VBD cord-015021-pol2qm74 7197 3 a a DT cord-015021-pol2qm74 7197 4 standardized standardized JJ cord-015021-pol2qm74 7197 5 surgical surgical JJ cord-015021-pol2qm74 7197 6 procedure procedure NN cord-015021-pol2qm74 7197 7 to to IN cord-015021-pol2qm74 7197 8 place place VB cord-015021-pol2qm74 7197 9 sampling sampling NN cord-015021-pol2qm74 7197 10 cathethers cathether NNS cord-015021-pol2qm74 7197 11 in in IN cord-015021-pol2qm74 7197 12 the the DT cord-015021-pol2qm74 7197 13 portal portal NN cord-015021-pol2qm74 7197 14 , , , cord-015021-pol2qm74 7197 15 hepatic hepatic JJ cord-015021-pol2qm74 7197 16 and and CC cord-015021-pol2qm74 7197 17 femoral femoral JJ cord-015021-pol2qm74 7197 18 veins vein NNS cord-015021-pol2qm74 7197 19 and and CC cord-015021-pol2qm74 7197 20 doppler doppler NN cord-015021-pol2qm74 7197 21 flow flow NN cord-015021-pol2qm74 7197 22 probes probe NNS cord-015021-pol2qm74 7197 23 around around IN cord-015021-pol2qm74 7197 24 the the DT cord-015021-pol2qm74 7197 25 portal portal JJ cord-015021-pol2qm74 7197 26 vein vein NN cord-015021-pol2qm74 7197 27 , , , cord-015021-pol2qm74 7197 28 the the DT cord-015021-pol2qm74 7197 29 hepatic hepatic JJ cord-015021-pol2qm74 7197 30 and and CC cord-015021-pol2qm74 7197 31 the the DT cord-015021-pol2qm74 7197 32 femoral femoral JJ cord-015021-pol2qm74 7197 33 arteries artery NNS cord-015021-pol2qm74 7197 34 . . . cord-015021-pol2qm74 7198 1 All all DT cord-015021-pol2qm74 7198 2 pigs pig NNS cord-015021-pol2qm74 7198 3 recieved recieve VBD cord-015021-pol2qm74 7198 4 a a DT cord-015021-pol2qm74 7198 5 primed prime VBN cord-015021-pol2qm74 7198 6 constant constant JJ cord-015021-pol2qm74 7198 7 infusion infusion NN cord-015021-pol2qm74 7198 8 of of IN cord-015021-pol2qm74 7198 9 U-14C u-14c NN cord-015021-pol2qm74 7198 10 - - HYPH cord-015021-pol2qm74 7198 11 glutamine glutamine NN cord-015021-pol2qm74 7198 12 . . . cord-015021-pol2qm74 7199 1 Substrate substrate NN cord-015021-pol2qm74 7199 2 fluxes flux NNS cord-015021-pol2qm74 7199 3 were be VBD cord-015021-pol2qm74 7199 4 measured measure VBN cord-015021-pol2qm74 7199 5 one one CD cord-015021-pol2qm74 7199 6 ( ( -LRB- cord-015021-pol2qm74 7199 7 lh lh NNP cord-015021-pol2qm74 7199 8 ) ) -RRB- cord-015021-pol2qm74 7199 9 and and CC cord-015021-pol2qm74 7199 10 five five CD cord-015021-pol2qm74 7199 11 ( ( -LRB- cord-015021-pol2qm74 7199 12 5b 5b NN cord-015021-pol2qm74 7199 13 ) ) -RRB- cord-015021-pol2qm74 7199 14 hours hour NNS cord-015021-pol2qm74 7199 15 after after IN cord-015021-pol2qm74 7199 16 termination termination NN cord-015021-pol2qm74 7199 17 of of IN cord-015021-pol2qm74 7199 18 the the DT cord-015021-pol2qm74 7199 19 surgery surgery NN cord-015021-pol2qm74 7199 20 . . . cord-015021-pol2qm74 7200 1 Nitrogen nitrogen NN cord-015021-pol2qm74 7200 2 excretion excretion NN cord-015021-pol2qm74 7200 3 was be VBD cord-015021-pol2qm74 7200 4 significantly significantly RB cord-015021-pol2qm74 7200 5 decreased decrease VBN cord-015021-pol2qm74 7200 6 in in IN cord-015021-pol2qm74 7200 7 the the DT cord-015021-pol2qm74 7200 8 GH GH NNP cord-015021-pol2qm74 7200 9 treated treat VBD cord-015021-pol2qm74 7200 10 animals animal NNS cord-015021-pol2qm74 7200 11 ( ( -LRB- cord-015021-pol2qm74 7201 1 GH-3:30.8 gh-3:30.8 NN cord-015021-pol2qm74 7201 2 + + SYM cord-015021-pol2qm74 7201 3 4.2 4.2 CD cord-015021-pol2qm74 7201 4 mg mg NNP cord-015021-pol2qm74 7201 5 / / SYM cord-015021-pol2qm74 7201 6 kg kg NNP cord-015021-pol2qm74 7202 1 , , , cord-015021-pol2qm74 7202 2 GH GH NNP cord-015021-pol2qm74 7202 3 - - HYPH cord-015021-pol2qm74 7202 4 I I NNP cord-015021-pol2qm74 7202 5 : : : cord-015021-pol2qm74 7203 1 37.6+_.5.8 37.6+_.5.8 CD cord-015021-pol2qm74 7203 2 mg mg NNP cord-015021-pol2qm74 7203 3 / / SYM cord-015021-pol2qm74 7203 4 kg kg NNP cord-015021-pol2qm74 7203 5 , , , cord-015021-pol2qm74 7203 6 CON con NN cord-015021-pol2qm74 7203 7 : : : cord-015021-pol2qm74 7203 8 55.4 55.4 CD cord-015021-pol2qm74 7203 9 + + SYM cord-015021-pol2qm74 7203 10 -3.1 -3.1 NNP cord-015021-pol2qm74 7203 11 mg mg NNP cord-015021-pol2qm74 7203 12 / / SYM cord-015021-pol2qm74 7203 13 kg kg NNP cord-015021-pol2qm74 7203 14 , , , cord-015021-pol2qm74 7203 15 p=0.004 p=0.004 NNP cord-015021-pol2qm74 7203 16 ) ) -RRB- cord-015021-pol2qm74 7203 17 . . . cord-015021-pol2qm74 7204 1 In in IN cord-015021-pol2qm74 7204 2 the the DT cord-015021-pol2qm74 7204 3 hindieg hindieg NN cord-015021-pol2qm74 7204 4 , , , cord-015021-pol2qm74 7204 5 there there EX cord-015021-pol2qm74 7204 6 was be VBD cord-015021-pol2qm74 7204 7 reduced reduce VBN cord-015021-pol2qm74 7204 8 net net JJ cord-015021-pol2qm74 7204 9 glutamine glutamine NN cord-015021-pol2qm74 7204 10 efflux efflux NN cord-015021-pol2qm74 7204 11 due due JJ cord-015021-pol2qm74 7204 12 to to IN cord-015021-pol2qm74 7204 13 decreased decrease VBN cord-015021-pol2qm74 7204 14 absolute absolute JJ cord-015021-pol2qm74 7204 15 glutamine glutamine NN cord-015021-pol2qm74 7204 16 release release NN cord-015021-pol2qm74 7204 17 ( ( -LRB- cord-015021-pol2qm74 7204 18 GH-3:0.9 GH-3:0.9 NNS cord-015021-pol2qm74 7204 19 + + SYM cord-015021-pol2qm74 7204 20 0.8gmol 0.8gmol . cord-015021-pol2qm74 7205 1 /min /min NFP cord-015021-pol2qm74 7205 2 at at IN cord-015021-pol2qm74 7205 3 lh lh NNP cord-015021-pol2qm74 7205 4 and and CC cord-015021-pol2qm74 7205 5 -2.4 -2.4 NN cord-015021-pol2qm74 7205 6 + + CC cord-015021-pol2qm74 7206 1 1.4 1.4 CD cord-015021-pol2qm74 7206 2 In.tool/rain in.tool/rain CD cord-015021-pol2qm74 7206 3 at at IN cord-015021-pol2qm74 7206 4 5h 5h CD cord-015021-pol2qm74 7206 5 , , , cord-015021-pol2qm74 7206 6 GH GH NNP cord-015021-pol2qm74 7206 7 - - HYPH cord-015021-pol2qm74 7206 8 I I NNP cord-015021-pol2qm74 7206 9 : : : cord-015021-pol2qm74 7206 10 -3.4 -3.4 NN cord-015021-pol2qm74 7206 11 + + CC cord-015021-pol2qm74 7207 1 1.5 1.5 CD cord-015021-pol2qm74 7207 2 I.tmol/min I.tmol/min NNP cord-015021-pol2qm74 7207 3 at at IN cord-015021-pol2qm74 7207 4 lh lh NNP cord-015021-pol2qm74 7207 5 and and CC cord-015021-pol2qm74 7207 6 -1.4 -1.4 CD cord-015021-pol2qm74 7207 7 + + CD cord-015021-pol2qm74 7208 1 1.2 1.2 CD cord-015021-pol2qm74 7208 2 pmol pmol NN cord-015021-pol2qm74 7208 3 / / SYM cord-015021-pol2qm74 7208 4 min min NN cord-015021-pol2qm74 7208 5 at at IN cord-015021-pol2qm74 7208 6 5h 5h NNP cord-015021-pol2qm74 7208 7 , , , cord-015021-pol2qm74 7208 8 CON con NN cord-015021-pol2qm74 7208 9 : : : cord-015021-pol2qm74 7208 10 -8.7+_2.8 -8.7+_2.8 . cord-015021-pol2qm74 7209 1 g g NNP cord-015021-pol2qm74 7209 2 mol mol NNP cord-015021-pol2qm74 7209 3 / / SYM cord-015021-pol2qm74 7209 4 min min NN cord-015021-pol2qm74 7209 5 at at IN cord-015021-pol2qm74 7209 6 lh lh NNP cord-015021-pol2qm74 7209 7 and and CC cord-015021-pol2qm74 7209 8 -11.6 -11.6 CD cord-015021-pol2qm74 7209 9 + + CC cord-015021-pol2qm74 7210 1 3.4 3.4 CD cord-015021-pol2qm74 7210 2 / / SYM cord-015021-pol2qm74 7210 3 amol amol NNP cord-015021-pol2qm74 7210 4 / / SYM cord-015021-pol2qm74 7210 5 min min NN cord-015021-pol2qm74 7210 6 at at IN cord-015021-pol2qm74 7210 7 5h 5h NNP cord-015021-pol2qm74 7210 8 , , , cord-015021-pol2qm74 7210 9 p=0.005 p=0.005 NNP cord-015021-pol2qm74 7210 10 , , , cord-015021-pol2qm74 7210 11 p=0.006 p=0.006 NNP cord-015021-pol2qm74 7210 12 ) ) -RRB- cord-015021-pol2qm74 7210 13 , , , cord-015021-pol2qm74 7210 14 whereas whereas IN cord-015021-pol2qm74 7210 15 the the DT cord-015021-pol2qm74 7210 16 absolute absolute JJ cord-015021-pol2qm74 7210 17 uptake uptake NN cord-015021-pol2qm74 7210 18 of of IN cord-015021-pol2qm74 7210 19 glutamine glutamine NN cord-015021-pol2qm74 7210 20 in in IN cord-015021-pol2qm74 7210 21 hindleg hindleg NNP cord-015021-pol2qm74 7210 22 was be VBD cord-015021-pol2qm74 7210 23 unchanged unchanged JJ cord-015021-pol2qm74 7210 24 ( ( -LRB- cord-015021-pol2qm74 7210 25 p=0.84 p=0.84 NNP cord-015021-pol2qm74 7210 26 ) ) -RRB- cord-015021-pol2qm74 7210 27 . . . cord-015021-pol2qm74 7211 1 Glucose glucose NN cord-015021-pol2qm74 7211 2 uptake uptake NN cord-015021-pol2qm74 7211 3 in in IN cord-015021-pol2qm74 7211 4 the the DT cord-015021-pol2qm74 7211 5 hindleg hindleg NN cord-015021-pol2qm74 7211 6 was be VBD cord-015021-pol2qm74 7211 7 decreased decrease VBN cord-015021-pol2qm74 7211 8 ( ( -LRB- cord-015021-pol2qm74 7211 9 p=0.0006 p=0.0006 NNS cord-015021-pol2qm74 7211 10 ) ) -RRB- cord-015021-pol2qm74 7211 11 . . . cord-015021-pol2qm74 7212 1 Net net JJ cord-015021-pol2qm74 7212 2 glutamine glutamine NN cord-015021-pol2qm74 7212 3 uptake uptake NN cord-015021-pol2qm74 7212 4 in in IN cord-015021-pol2qm74 7212 5 liver liver NN cord-015021-pol2qm74 7212 6 was be VBD cord-015021-pol2qm74 7212 7 attenuated attenuate VBN cord-015021-pol2qm74 7212 8 ( ( -LRB- cord-015021-pol2qm74 7212 9 p=0.03 p=0.03 NN cord-015021-pol2qm74 7212 10 at at IN cord-015021-pol2qm74 7212 11 5h 5h CD cord-015021-pol2qm74 7212 12 ) ) -RRB- cord-015021-pol2qm74 7212 13 , , , cord-015021-pol2qm74 7212 14 whereas whereas IN cord-015021-pol2qm74 7212 15 net net JJ cord-015021-pol2qm74 7212 16 glutamate glutamate NN cord-015021-pol2qm74 7212 17 release release NN cord-015021-pol2qm74 7212 18 from from IN cord-015021-pol2qm74 7212 19 liver liver NN cord-015021-pol2qm74 7212 20 was be VBD cord-015021-pol2qm74 7212 21 increased increase VBN cord-015021-pol2qm74 7212 22 ( ( -LRB- cord-015021-pol2qm74 7212 23 p=0.005 p=0.005 NNP cord-015021-pol2qm74 7212 24 ) ) -RRB- cord-015021-pol2qm74 7212 25 . . . cord-015021-pol2qm74 7213 1 Thus thus RB cord-015021-pol2qm74 7213 2 , , , cord-015021-pol2qm74 7213 3 pre pre JJ cord-015021-pol2qm74 7213 4 - - JJ cord-015021-pol2qm74 7213 5 trauma trauma JJ cord-015021-pol2qm74 7213 6 treatment treatment NN cord-015021-pol2qm74 7213 7 with with IN cord-015021-pol2qm74 7213 8 GH GH NNP cord-015021-pol2qm74 7213 9 improved improve VBD cord-015021-pol2qm74 7213 10 nitrogen nitrogen NN cord-015021-pol2qm74 7213 11 economy economy NN cord-015021-pol2qm74 7213 12 , , , cord-015021-pol2qm74 7213 13 attenuated attenuated JJ cord-015021-pol2qm74 7213 14 net net JJ cord-015021-pol2qm74 7213 15 glutamine glutamine NN cord-015021-pol2qm74 7213 16 loss loss NN cord-015021-pol2qm74 7213 17 from from IN cord-015021-pol2qm74 7213 18 hindieg hindieg NNP cord-015021-pol2qm74 7213 19 due due IN cord-015021-pol2qm74 7213 20 to to IN cord-015021-pol2qm74 7213 21 decreased decrease VBN cord-015021-pol2qm74 7213 22 absolute absolute JJ cord-015021-pol2qm74 7213 23 release release NN cord-015021-pol2qm74 7213 24 , , , cord-015021-pol2qm74 7213 25 and and CC cord-015021-pol2qm74 7213 26 attenuated attenuated JJ cord-015021-pol2qm74 7213 27 hindleg hindleg NNP cord-015021-pol2qm74 7213 28 glucose glucose NN cord-015021-pol2qm74 7213 29 uptake uptake NN cord-015021-pol2qm74 7213 30 . . . cord-015021-pol2qm74 7214 1 Liver liver NN cord-015021-pol2qm74 7214 2 net net JJ cord-015021-pol2qm74 7214 3 glutanaine glutanaine NN cord-015021-pol2qm74 7214 4 uptake uptake NN cord-015021-pol2qm74 7214 5 was be VBD cord-015021-pol2qm74 7214 6 decerased decerase VBN cord-015021-pol2qm74 7214 7 and and CC cord-015021-pol2qm74 7214 8 net net JJ cord-015021-pol2qm74 7214 9 glutamate glutamate NN cord-015021-pol2qm74 7214 10 release release NN cord-015021-pol2qm74 7214 11 increased increase VBD cord-015021-pol2qm74 7214 12 . . . cord-015021-pol2qm74 7215 1 Patients patient NNS cord-015021-pol2qm74 7215 2 with with IN cord-015021-pol2qm74 7215 3 major major JJ cord-015021-pol2qm74 7215 4 abdominal abdominal JJ cord-015021-pol2qm74 7215 5 surgery surgery NN cord-015021-pol2qm74 7215 6 exhibit exhibit NN cord-015021-pol2qm74 7215 7 a a DT cord-015021-pol2qm74 7215 8 considerable considerable JJ cord-015021-pol2qm74 7215 9 catabolic catabolic JJ cord-015021-pol2qm74 7215 10 response response NN cord-015021-pol2qm74 7215 11 with with IN cord-015021-pol2qm74 7215 12 negative negative JJ cord-015021-pol2qm74 7215 13 nitrogen nitrogen NN cord-015021-pol2qm74 7215 14 balance balance NN cord-015021-pol2qm74 7215 15 and and CC cord-015021-pol2qm74 7215 16 protein protein NN cord-015021-pol2qm74 7215 17 breakdown breakdown NN cord-015021-pol2qm74 7215 18 , , , cord-015021-pol2qm74 7215 19 which which WDT cord-015021-pol2qm74 7215 20 may may MD cord-015021-pol2qm74 7215 21 have have VB cord-015021-pol2qm74 7215 22 detrimental detrimental JJ cord-015021-pol2qm74 7215 23 effects effect NNS cord-015021-pol2qm74 7215 24 on on IN cord-015021-pol2qm74 7215 25 outcome outcome NN cord-015021-pol2qm74 7215 26 . . . cord-015021-pol2qm74 7216 1 We -PRON- PRP cord-015021-pol2qm74 7216 2 investigated investigate VBD cord-015021-pol2qm74 7216 3 the the DT cord-015021-pol2qm74 7216 4 effects effect NNS cord-015021-pol2qm74 7216 5 recombinant recombinant JJ cord-015021-pol2qm74 7216 6 human human JJ cord-015021-pol2qm74 7216 7 growth growth NN cord-015021-pol2qm74 7216 8 hormone hormone NN cord-015021-pol2qm74 7216 9 on on IN cord-015021-pol2qm74 7216 10 substrate substrate JJ cord-015021-pol2qm74 7216 11 metabolism metabolism NN cord-015021-pol2qm74 7216 12 in in IN cord-015021-pol2qm74 7216 13 parenterally parenterally NN cord-015021-pol2qm74 7216 14 fed feed VBN cord-015021-pol2qm74 7216 15 patients patient NNS cord-015021-pol2qm74 7216 16 . . . cord-015021-pol2qm74 7217 1 48 48 CD cord-015021-pol2qm74 7217 2 metabolic metabolic JJ cord-015021-pol2qm74 7217 3 healthy healthy JJ cord-015021-pol2qm74 7217 4 patients patient NNS cord-015021-pol2qm74 7217 5 were be VBD cord-015021-pol2qm74 7217 6 randomized randomize VBN cord-015021-pol2qm74 7217 7 to to TO cord-015021-pol2qm74 7217 8 receive receive VB cord-015021-pol2qm74 7217 9 either either CC cord-015021-pol2qm74 7217 10 placebo placebo NN cord-015021-pol2qm74 7217 11 or or CC cord-015021-pol2qm74 7217 12 HGH hgh NN cord-015021-pol2qm74 7217 13 in in IN cord-015021-pol2qm74 7217 14 a a DT cord-015021-pol2qm74 7217 15 dosage dosage NN cord-015021-pol2qm74 7217 16 of of IN cord-015021-pol2qm74 7217 17 0,075 0,075 CD cord-015021-pol2qm74 7218 1 ; ; : cord-015021-pol2qm74 7218 2 0,15 0,15 CD cord-015021-pol2qm74 7218 3 or or CC cord-015021-pol2qm74 7218 4 0,3 0,3 CD cord-015021-pol2qm74 7218 5 I.U. I.U. NNP cord-015021-pol2qm74 7218 6 per per IN cord-015021-pol2qm74 7218 7 kg kg NNP cord-015021-pol2qm74 7218 8 BW BW NNP cord-015021-pol2qm74 7218 9 . . . cord-015021-pol2qm74 7219 1 Substrate substrate NN cord-015021-pol2qm74 7219 2 oxidation oxidation NN cord-015021-pol2qm74 7219 3 rate rate NN cord-015021-pol2qm74 7219 4 , , , cord-015021-pol2qm74 7219 5 energy energy NN cord-015021-pol2qm74 7219 6 expenditure expenditure NN cord-015021-pol2qm74 7219 7 as as RB cord-015021-pol2qm74 7219 8 well well RB cord-015021-pol2qm74 7219 9 as as IN cord-015021-pol2qm74 7219 10 short short JJ cord-015021-pol2qm74 7219 11 life life NN cord-015021-pol2qm74 7219 12 proteins protein NNS cord-015021-pol2qm74 7219 13 were be VBD cord-015021-pol2qm74 7219 14 measured measure VBN cord-015021-pol2qm74 7219 15 daily daily RB cord-015021-pol2qm74 7219 16 . . . cord-015021-pol2qm74 7220 1 Six six CD cord-015021-pol2qm74 7220 2 patients patient NNS cord-015021-pol2qm74 7220 3 were be VBD cord-015021-pol2qm74 7220 4 excluded exclude VBN cord-015021-pol2qm74 7220 5 from from IN cord-015021-pol2qm74 7220 6 analysis analysis NN cord-015021-pol2qm74 7220 7 as as IN cord-015021-pol2qm74 7220 8 drop drop NN cord-015021-pol2qm74 7220 9 outs out NNS cord-015021-pol2qm74 7220 10 , , , cord-015021-pol2qm74 7220 11 due due IN cord-015021-pol2qm74 7220 12 to to IN cord-015021-pol2qm74 7220 13 surgical surgical JJ cord-015021-pol2qm74 7220 14 complications complication NNS cord-015021-pol2qm74 7220 15 . . . cord-015021-pol2qm74 7221 1 We -PRON- PRP cord-015021-pol2qm74 7221 2 could could MD cord-015021-pol2qm74 7221 3 find find VB cord-015021-pol2qm74 7221 4 a a DT cord-015021-pol2qm74 7221 5 dose dose NN cord-015021-pol2qm74 7221 6 - - HYPH cord-015021-pol2qm74 7221 7 dependend dependend NN cord-015021-pol2qm74 7221 8 effect effect NN cord-015021-pol2qm74 7221 9 of of IN cord-015021-pol2qm74 7221 10 growth growth NN cord-015021-pol2qm74 7221 11 hormone hormone NN cord-015021-pol2qm74 7221 12 on on IN cord-015021-pol2qm74 7221 13 resting rest VBG cord-015021-pol2qm74 7221 14 energy energy NN cord-015021-pol2qm74 7221 15 expenditure expenditure NN cord-015021-pol2qm74 7221 16 , , , cord-015021-pol2qm74 7221 17 carbohydrate carbohydrate NN cord-015021-pol2qm74 7221 18 oxidation oxidation NN cord-015021-pol2qm74 7221 19 , , , cord-015021-pol2qm74 7221 20 fat fat JJ cord-015021-pol2qm74 7221 21 and and CC cord-015021-pol2qm74 7221 22 proteine proteine JJ cord-015021-pol2qm74 7221 23 oxidation oxidation NN cord-015021-pol2qm74 7221 24 . . . cord-015021-pol2qm74 7222 1 With with IN cord-015021-pol2qm74 7222 2 increasing increase VBG cord-015021-pol2qm74 7222 3 growth growth NN cord-015021-pol2qm74 7222 4 hormone hormone NN cord-015021-pol2qm74 7222 5 resting rest VBG cord-015021-pol2qm74 7222 6 energy energy NN cord-015021-pol2qm74 7222 7 expenditure expenditure NN cord-015021-pol2qm74 7222 8 increased increase VBD cord-015021-pol2qm74 7222 9 from from IN cord-015021-pol2qm74 7222 10 20.9 20.9 CD cord-015021-pol2qm74 7222 11 calories calorie NNS cord-015021-pol2qm74 7222 12 per per IN cord-015021-pol2qm74 7222 13 kg kg NN cord-015021-pol2qm74 7222 14 body body NN cord-015021-pol2qm74 7222 15 weight weight NN cord-015021-pol2qm74 7222 16 to to IN cord-015021-pol2qm74 7222 17 26.6 26.6 CD cord-015021-pol2qm74 7222 18 calories calorie NNS cord-015021-pol2qm74 7222 19 . . . cord-015021-pol2qm74 7223 1 This this DT cord-015021-pol2qm74 7223 2 was be VBD cord-015021-pol2qm74 7223 3 mainly mainly RB cord-015021-pol2qm74 7223 4 due due JJ cord-015021-pol2qm74 7223 5 to to IN cord-015021-pol2qm74 7223 6 an an DT cord-015021-pol2qm74 7223 7 increased increase VBN cord-015021-pol2qm74 7223 8 carbohydrate carbohydrate NN cord-015021-pol2qm74 7223 9 and and CC cord-015021-pol2qm74 7223 10 fat fat JJ cord-015021-pol2qm74 7223 11 oxidation oxidation NN cord-015021-pol2qm74 7223 12 , , , cord-015021-pol2qm74 7223 13 while while IN cord-015021-pol2qm74 7223 14 proteine proteine NNP cord-015021-pol2qm74 7223 15 oxidation oxidation NN cord-015021-pol2qm74 7223 16 decreased decrease VBD cord-015021-pol2qm74 7223 17 . . . cord-015021-pol2qm74 7224 1 This this DT cord-015021-pol2qm74 7224 2 was be VBD cord-015021-pol2qm74 7224 3 in in IN cord-015021-pol2qm74 7224 4 accordance accordance NN cord-015021-pol2qm74 7224 5 with with IN cord-015021-pol2qm74 7224 6 a a DT cord-015021-pol2qm74 7224 7 decreased decrease VBN cord-015021-pol2qm74 7224 8 urea.production urea.production NN cord-015021-pol2qm74 7224 9 rate rate NN cord-015021-pol2qm74 7224 10 and and CC cord-015021-pol2qm74 7224 11 an an DT cord-015021-pol2qm74 7224 12 improvement improvement NN cord-015021-pol2qm74 7224 13 in in IN cord-015021-pol2qm74 7224 14 cumulative cumulative JJ cord-015021-pol2qm74 7224 15 nitrogene nitrogene JJ cord-015021-pol2qm74 7224 16 balance balance NN cord-015021-pol2qm74 7224 17 , , , cord-015021-pol2qm74 7224 18 which which WDT cord-015021-pol2qm74 7224 19 increased increase VBD cord-015021-pol2qm74 7224 20 from from IN cord-015021-pol2qm74 7224 21 minus minus IN cord-015021-pol2qm74 7224 22 12.7 12.7 CD cord-015021-pol2qm74 7224 23 to to IN cord-015021-pol2qm74 7224 24 plus plus CC cord-015021-pol2qm74 7224 25 8.5 8.5 CD cord-015021-pol2qm74 7224 26 g g NN cord-015021-pol2qm74 7224 27 N n CD cord-015021-pol2qm74 7224 28 / / SYM cord-015021-pol2qm74 7224 29 7 7 CD cord-015021-pol2qm74 7224 30 days day NNS cord-015021-pol2qm74 7224 31 . . . cord-015021-pol2qm74 7225 1 In in IN cord-015021-pol2qm74 7225 2 consequence consequence JJ cord-015021-pol2qm74 7225 3 short short JJ cord-015021-pol2qm74 7225 4 life life NN cord-015021-pol2qm74 7225 5 proteins protein NNS cord-015021-pol2qm74 7225 6 were be VBD cord-015021-pol2qm74 7225 7 also also RB cord-015021-pol2qm74 7225 8 increased increase VBN cord-015021-pol2qm74 7225 9 . . . cord-015021-pol2qm74 7226 1 The the DT cord-015021-pol2qm74 7226 2 only only JJ cord-015021-pol2qm74 7226 3 negative negative JJ cord-015021-pol2qm74 7226 4 side side NN cord-015021-pol2qm74 7226 5 effect effect NN cord-015021-pol2qm74 7226 6 was be VBD cord-015021-pol2qm74 7226 7 an an DT cord-015021-pol2qm74 7226 8 increased increase VBN cord-015021-pol2qm74 7226 9 blood blood NN cord-015021-pol2qm74 7226 10 glucose glucose NN cord-015021-pol2qm74 7226 11 concentration concentration NN cord-015021-pol2qm74 7226 12 in in IN cord-015021-pol2qm74 7226 13 some some DT cord-015021-pol2qm74 7226 14 of of IN cord-015021-pol2qm74 7226 15 the the DT cord-015021-pol2qm74 7226 16 patients patient NNS cord-015021-pol2qm74 7226 17 , , , cord-015021-pol2qm74 7226 18 making make VBG cord-015021-pol2qm74 7226 19 insuline insuline NNP cord-015021-pol2qm74 7226 20 administration administration NN cord-015021-pol2qm74 7226 21 mandatory mandatory JJ cord-015021-pol2qm74 7226 22 in in IN cord-015021-pol2qm74 7226 23 3 3 CD cord-015021-pol2qm74 7226 24 patients patient NNS cord-015021-pol2qm74 7226 25 . . . cord-015021-pol2qm74 7227 1 Our -PRON- PRP$ cord-015021-pol2qm74 7227 2 results result NNS cord-015021-pol2qm74 7227 3 are be VBP cord-015021-pol2qm74 7227 4 in in IN cord-015021-pol2qm74 7227 5 accordance accordance NN cord-015021-pol2qm74 7227 6 with with IN cord-015021-pol2qm74 7227 7 other other JJ cord-015021-pol2qm74 7227 8 studies study NNS cord-015021-pol2qm74 7227 9 showing show VBG cord-015021-pol2qm74 7227 10 improvement improvement NN cord-015021-pol2qm74 7227 11 of of IN cord-015021-pol2qm74 7227 12 nitrogen nitrogen NN cord-015021-pol2qm74 7227 13 balance balance NN cord-015021-pol2qm74 7227 14 , , , cord-015021-pol2qm74 7227 15 maintainance maintainance NN cord-015021-pol2qm74 7227 16 of of IN cord-015021-pol2qm74 7227 17 lean lean JJ cord-015021-pol2qm74 7227 18 body body NN cord-015021-pol2qm74 7227 19 mass mass NN cord-015021-pol2qm74 7227 20 and and CC cord-015021-pol2qm74 7227 21 muscular muscular JJ cord-015021-pol2qm74 7227 22 strength strength NN cord-015021-pol2qm74 7227 23 . . . cord-015021-pol2qm74 7228 1 If if IN cord-015021-pol2qm74 7228 2 growth growth NN cord-015021-pol2qm74 7228 3 hormone hormone NN cord-015021-pol2qm74 7228 4 administration administration NN cord-015021-pol2qm74 7228 5 may may MD cord-015021-pol2qm74 7228 6 have have VB cord-015021-pol2qm74 7228 7 any any DT cord-015021-pol2qm74 7228 8 impact impact NN cord-015021-pol2qm74 7228 9 on on IN cord-015021-pol2qm74 7228 10 morbidity morbidity NN cord-015021-pol2qm74 7228 11 , , , cord-015021-pol2qm74 7228 12 mortality mortality NN cord-015021-pol2qm74 7228 13 and and CC cord-015021-pol2qm74 7228 14 length length NN cord-015021-pol2qm74 7228 15 of of IN cord-015021-pol2qm74 7228 16 hospital hospital NN cord-015021-pol2qm74 7228 17 stay stay NN cord-015021-pol2qm74 7228 18 in in IN cord-015021-pol2qm74 7228 19 these these DT cord-015021-pol2qm74 7228 20 patients patient NNS cord-015021-pol2qm74 7228 21 it -PRON- PRP cord-015021-pol2qm74 7228 22 should should MD cord-015021-pol2qm74 7228 23 be be VB cord-015021-pol2qm74 7228 24 evaluated evaluate VBN cord-015021-pol2qm74 7228 25 in in IN cord-015021-pol2qm74 7228 26 a a DT cord-015021-pol2qm74 7228 27 larger large JJR cord-015021-pol2qm74 7228 28 number number NN cord-015021-pol2qm74 7228 29 of of IN cord-015021-pol2qm74 7228 30 patients patient NNS cord-015021-pol2qm74 7228 31 . . . cord-015021-pol2qm74 7229 1 In in IN cord-015021-pol2qm74 7229 2 30 30 CD cord-015021-pol2qm74 7229 3 patient patient NN cord-015021-pol2qm74 7229 4 after after IN cord-015021-pol2qm74 7229 5 liver liver NN cord-015021-pol2qm74 7229 6 transplantation transplantation NN cord-015021-pol2qm74 7229 7 ( ( -LRB- cord-015021-pol2qm74 7229 8 OLTx OLTx NNP cord-015021-pol2qm74 7229 9 ) ) -RRB- cord-015021-pol2qm74 7229 10 the the DT cord-015021-pol2qm74 7229 11 effect effect NN cord-015021-pol2qm74 7229 12 of of IN cord-015021-pol2qm74 7229 13 recombinant recombinant JJ cord-015021-pol2qm74 7229 14 human human JJ cord-015021-pol2qm74 7229 15 growth growth NN cord-015021-pol2qm74 7229 16 hormone hormone NN cord-015021-pol2qm74 7229 17 ( ( -LRB- cord-015021-pol2qm74 7229 18 rhGH rhGH NNP cord-015021-pol2qm74 7229 19 ) ) -RRB- cord-015021-pol2qm74 7229 20 on on IN cord-015021-pol2qm74 7229 21 protein protein NN cord-015021-pol2qm74 7229 22 metabolism metabolism NN cord-015021-pol2qm74 7229 23 and and CC cord-015021-pol2qm74 7229 24 hormonal hormonal JJ cord-015021-pol2qm74 7229 25 changes change NNS cord-015021-pol2qm74 7229 26 was be VBD cord-015021-pol2qm74 7229 27 studied study VBN cord-015021-pol2qm74 7229 28 . . . cord-015021-pol2qm74 7230 1 Patients patient NNS cord-015021-pol2qm74 7230 2 and and CC cord-015021-pol2qm74 7230 3 methods method NNS cord-015021-pol2qm74 7231 1 : : : cord-015021-pol2qm74 7231 2 the the DT cord-015021-pol2qm74 7231 3 underlying underlie VBG cord-015021-pol2qm74 7231 4 disease disease NN cord-015021-pol2qm74 7231 5 in in IN cord-015021-pol2qm74 7231 6 all all DT cord-015021-pol2qm74 7231 7 patients patient NNS cord-015021-pol2qm74 7231 8 was be VBD cord-015021-pol2qm74 7232 1 end end VB cord-015021-pol2qm74 7232 2 stage stage NN cord-015021-pol2qm74 7232 3 liver liver NN cord-015021-pol2qm74 7232 4 cirrhosis cirrhosis NN cord-015021-pol2qm74 7232 5 , , , cord-015021-pol2qm74 7232 6 non non JJ cord-015021-pol2qm74 7232 7 of of IN cord-015021-pol2qm74 7232 8 the the DT cord-015021-pol2qm74 7232 9 patients patient NNS cord-015021-pol2qm74 7232 10 included include VBN cord-015021-pol2qm74 7232 11 in in IN cord-015021-pol2qm74 7232 12 the the DT cord-015021-pol2qm74 7232 13 study study NN cord-015021-pol2qm74 7232 14 was be VBD cord-015021-pol2qm74 7232 15 suffering suffer VBG cord-015021-pol2qm74 7232 16 from from IN cord-015021-pol2qm74 7232 17 malignancies malignancy NNS cord-015021-pol2qm74 7232 18 . . . cord-015021-pol2qm74 7233 1 The the DT cord-015021-pol2qm74 7233 2 patients patient NNS cord-015021-pol2qm74 7233 3 were be VBD cord-015021-pol2qm74 7233 4 randomly randomly RB cord-015021-pol2qm74 7233 5 allocated allocate VBN cord-015021-pol2qm74 7233 6 to to TO cord-015021-pol2qm74 7233 7 receive receive VB cord-015021-pol2qm74 7233 8 either either DT cord-015021-pol2qm74 7233 9 81U 81u CD cord-015021-pol2qm74 7233 10 of of IN cord-015021-pol2qm74 7233 11 rhGH rhGH NNP cord-015021-pol2qm74 7233 12 bid bid NNP cord-015021-pol2qm74 7233 13 ( ( -LRB- cord-015021-pol2qm74 7233 14 sc sc NNP cord-015021-pol2qm74 7233 15 ) ) -RRB- cord-015021-pol2qm74 7233 16 or or CC cord-015021-pol2qm74 7233 17 no no DT cord-015021-pol2qm74 7233 18 alternative alternative JJ cord-015021-pol2qm74 7233 19 medication medication NN cord-015021-pol2qm74 7233 20 . . . cord-015021-pol2qm74 7234 1 The the DT cord-015021-pol2qm74 7234 2 study study NN cord-015021-pol2qm74 7234 3 period period NN cord-015021-pol2qm74 7234 4 lasted last VBD cord-015021-pol2qm74 7234 5 14 14 CD cord-015021-pol2qm74 7234 6 days day NNS cord-015021-pol2qm74 7234 7 . . . cord-015021-pol2qm74 7235 1 From from IN cord-015021-pol2qm74 7235 2 daily daily JJ cord-015021-pol2qm74 7235 3 24 24 CD cord-015021-pol2qm74 7235 4 hrs hrs NN cord-015021-pol2qm74 7235 5 udne udne NN cord-015021-pol2qm74 7235 6 collection collection NN cord-015021-pol2qm74 7235 7 urinary urinary JJ cord-015021-pol2qm74 7235 8 nitrogen nitrogen NN cord-015021-pol2qm74 7235 9 loss loss NN cord-015021-pol2qm74 7235 10 and and CC cord-015021-pol2qm74 7235 11 daily daily JJ cord-015021-pol2qm74 7235 12 loss loss NN cord-015021-pol2qm74 7235 13 of of IN cord-015021-pol2qm74 7235 14 urea urea NN cord-015021-pol2qm74 7235 15 were be VBD cord-015021-pol2qm74 7235 16 determined determine VBN cord-015021-pol2qm74 7235 17 . . . cord-015021-pol2qm74 7236 1 Body body NN cord-015021-pol2qm74 7236 2 compostion compostion NN cord-015021-pol2qm74 7236 3 analysis analysis NN cord-015021-pol2qm74 7236 4 ( ( -LRB- cord-015021-pol2qm74 7236 5 BCA BCA NNP cord-015021-pol2qm74 7236 6 , , , cord-015021-pol2qm74 7236 7 bioimpedance bioimpedance NN cord-015021-pol2qm74 7236 8 , , , cord-015021-pol2qm74 7236 9 Akern Akern NNP cord-015021-pol2qm74 7236 10 - - HYPH cord-015021-pol2qm74 7236 11 ltaly ltaly NNP cord-015021-pol2qm74 7236 12 ) ) -RRB- cord-015021-pol2qm74 7236 13 was be VBD cord-015021-pol2qm74 7236 14 performed perform VBN cord-015021-pol2qm74 7236 15 preoperativly preoperativly NNP cord-015021-pol2qm74 7236 16 and and CC cord-015021-pol2qm74 7236 17 at at IN cord-015021-pol2qm74 7236 18 the the DT cord-015021-pol2qm74 7236 19 postoperative postoperative JJ cord-015021-pol2qm74 7236 20 days day NNS cord-015021-pol2qm74 7236 21 7 7 CD cord-015021-pol2qm74 7236 22 and and CC cord-015021-pol2qm74 7236 23 14 14 CD cord-015021-pol2qm74 7236 24 to to TO cord-015021-pol2qm74 7236 25 evaluate evaluate VB cord-015021-pol2qm74 7236 26 changes change NNS cord-015021-pol2qm74 7236 27 in in IN cord-015021-pol2qm74 7236 28 body body NN cord-015021-pol2qm74 7236 29 water water NN cord-015021-pol2qm74 7236 30 and and CC cord-015021-pol2qm74 7236 31 body body NN cord-015021-pol2qm74 7236 32 cell cell NN cord-015021-pol2qm74 7236 33 mass mass NN cord-015021-pol2qm74 7236 34 ( ( -LRB- cord-015021-pol2qm74 7236 35 BCM BCM NNP cord-015021-pol2qm74 7236 36 ) ) -RRB- cord-015021-pol2qm74 7236 37 . . . cord-015021-pol2qm74 7237 1 The the DT cord-015021-pol2qm74 7237 2 effect effect NN cord-015021-pol2qm74 7237 3 on on IN cord-015021-pol2qm74 7237 4 resting rest VBG cord-015021-pol2qm74 7237 5 energy energy NN cord-015021-pol2qm74 7237 6 expenditure expenditure NN cord-015021-pol2qm74 7237 7 ( ( -LRB- cord-015021-pol2qm74 7237 8 REE REE NNP cord-015021-pol2qm74 7237 9 ) ) -RRB- cord-015021-pol2qm74 7237 10 was be VBD cord-015021-pol2qm74 7237 11 analysed analyse VBN cord-015021-pol2qm74 7237 12 using use VBG cord-015021-pol2qm74 7237 13 indirekt indirekt NN cord-015021-pol2qm74 7237 14 calorimetry calorimetry NN cord-015021-pol2qm74 7237 15 wRhin wRhin NNP cord-015021-pol2qm74 7237 16 the the DT cord-015021-pol2qm74 7237 17 same same JJ cord-015021-pol2qm74 7237 18 intervalls intervall NNS cord-015021-pol2qm74 7237 19 ( ( -LRB- cord-015021-pol2qm74 7237 20 Metabolic metabolic JJ cord-015021-pol2qm74 7237 21 monitor monitor NN cord-015021-pol2qm74 7237 22 , , , cord-015021-pol2qm74 7237 23 Datex Datex NNP cord-015021-pol2qm74 7237 24 ) ) -RRB- cord-015021-pol2qm74 7237 25 . . . cord-015021-pol2qm74 7238 1 Blood blood NN cord-015021-pol2qm74 7238 2 levels level NNS cord-015021-pol2qm74 7238 3 of of IN cord-015021-pol2qm74 7238 4 GH GH NNP cord-015021-pol2qm74 7238 5 , , , cord-015021-pol2qm74 7238 6 IGF1 IGF1 NNP cord-015021-pol2qm74 7238 7 and and CC cord-015021-pol2qm74 7238 8 IGF2 IGF2 NNP cord-015021-pol2qm74 7238 9 , , , cord-015021-pol2qm74 7238 10 IGFBP3 IGFBP3 NNP cord-015021-pol2qm74 7238 11 were be VBD cord-015021-pol2qm74 7238 12 measured measure VBN cord-015021-pol2qm74 7238 13 daily daily RB cord-015021-pol2qm74 7238 14 during during IN cord-015021-pol2qm74 7238 15 the the DT cord-015021-pol2qm74 7238 16 study study NN cord-015021-pol2qm74 7238 17 period period NN cord-015021-pol2qm74 7238 18 , , , cord-015021-pol2qm74 7238 19 on on IN cord-015021-pol2qm74 7238 20 day day NN cord-015021-pol2qm74 7238 21 3 3 CD cord-015021-pol2qm74 7238 22 a a DT cord-015021-pol2qm74 7238 23 24 24 CD cord-015021-pol2qm74 7238 24 hour hour NN cord-015021-pol2qm74 7238 25 profile profile NN cord-015021-pol2qm74 7238 26 of of IN cord-015021-pol2qm74 7238 27 GH GH NNP cord-015021-pol2qm74 7238 28 was.performed was.performed NNP cord-015021-pol2qm74 7238 29 . . . cord-015021-pol2qm74 7238 30 Samples sample NNS cord-015021-pol2qm74 7238 31 were be VBD cord-015021-pol2qm74 7238 32 collected collect VBN cord-015021-pol2qm74 7238 33 each each DT cord-015021-pol2qm74 7238 34 20 20 CD cord-015021-pol2qm74 7238 35 minutes minute NNS cord-015021-pol2qm74 7238 36 . . . cord-015021-pol2qm74 7239 1 Results result NNS cord-015021-pol2qm74 7239 2 : : : cord-015021-pol2qm74 7240 1 cumulative cumulative JJ cord-015021-pol2qm74 7240 2 udnary udnary JJ cord-015021-pol2qm74 7240 3 nitrogen nitrogen NN cord-015021-pol2qm74 7240 4 and and CC cord-015021-pol2qm74 7240 5 urea urea NN cord-015021-pol2qm74 7240 6 loss loss NN cord-015021-pol2qm74 7240 7 were be VBD cord-015021-pol2qm74 7240 8 not not RB cord-015021-pol2qm74 7240 9 signifcantly signifcantly RB cord-015021-pol2qm74 7240 10 different different JJ cord-015021-pol2qm74 7240 11 for for IN cord-015021-pol2qm74 7240 12 the the DT cord-015021-pol2qm74 7240 13 whole whole JJ cord-015021-pol2qm74 7240 14 study study NN cord-015021-pol2qm74 7240 15 period period NN cord-015021-pol2qm74 7240 16 but but CC cord-015021-pol2qm74 7240 17 for for IN cord-015021-pol2qm74 7240 18 the the DT cord-015021-pol2qm74 7240 19 first first JJ cord-015021-pol2qm74 7240 20 4 4 CD cord-015021-pol2qm74 7240 21 study study NN cord-015021-pol2qm74 7240 22 days day NNS cord-015021-pol2qm74 7240 23 . . . cord-015021-pol2qm74 7241 1 BIA BIA NNP cord-015021-pol2qm74 7241 2 indicated indicate VBD cord-015021-pol2qm74 7241 3 for for IN cord-015021-pol2qm74 7241 4 the the DT cord-015021-pol2qm74 7241 5 rhGH rhgh NN cord-015021-pol2qm74 7241 6 - - HYPH cord-015021-pol2qm74 7241 7 group group NN cord-015021-pol2qm74 7241 8 a a DT cord-015021-pol2qm74 7241 9 loss loss NN cord-015021-pol2qm74 7241 10 of of IN cord-015021-pol2qm74 7241 11 BCM bcm NN cord-015021-pol2qm74 7241 12 to to IN cord-015021-pol2qm74 7241 13 a a DT cord-015021-pol2qm74 7241 14 lesser less JJR cord-015021-pol2qm74 7241 15 extent extent NN cord-015021-pol2qm74 7241 16 than than IN cord-015021-pol2qm74 7241 17 for for IN cord-015021-pol2qm74 7241 18 the the DT cord-015021-pol2qm74 7241 19 controls control NNS cord-015021-pol2qm74 7241 20 ( ( -LRB- cord-015021-pol2qm74 7241 21 n.s n.s NNP cord-015021-pol2qm74 7241 22 . . NNP cord-015021-pol2qm74 7241 23 ) ) -RRB- cord-015021-pol2qm74 7241 24 , , , cord-015021-pol2qm74 7241 25 changes change VBZ cord-015021-pol2qm74 7241 26 in in IN cord-015021-pol2qm74 7241 27 bodywater bodywater NNP cord-015021-pol2qm74 7241 28 where where WRB cord-015021-pol2qm74 7241 29 similar similar JJ cord-015021-pol2qm74 7241 30 for for IN cord-015021-pol2qm74 7241 31 both both DT cord-015021-pol2qm74 7241 32 groups group NNS cord-015021-pol2qm74 7241 33 . . . cord-015021-pol2qm74 7242 1 REE REE NNP cord-015021-pol2qm74 7242 2 changes change NNS cord-015021-pol2qm74 7242 3 ( ( -LRB- cord-015021-pol2qm74 7242 4 kcal kcal NNP cord-015021-pol2qm74 7242 5 / / SYM cord-015021-pol2qm74 7242 6 kg kg NNP cord-015021-pol2qm74 7242 7 BCM BCM NNP cord-015021-pol2qm74 7242 8 ) ) -RRB- cord-015021-pol2qm74 7242 9 were be VBD cord-015021-pol2qm74 7242 10 not not RB cord-015021-pol2qm74 7242 11 significantly significantly RB cord-015021-pol2qm74 7242 12 different different JJ cord-015021-pol2qm74 7242 13 for for IN cord-015021-pol2qm74 7242 14 the the DT cord-015021-pol2qm74 7242 15 two two CD cord-015021-pol2qm74 7242 16 groups group NNS cord-015021-pol2qm74 7242 17 . . . cord-015021-pol2qm74 7243 1 Blood blood NN cord-015021-pol2qm74 7243 2 levels level NNS cord-015021-pol2qm74 7243 3 of of IN cord-015021-pol2qm74 7243 4 GH GH NNP cord-015021-pol2qm74 7243 5 and and CC cord-015021-pol2qm74 7243 6 IGF1 IGF1 NNP cord-015021-pol2qm74 7243 7 differed differ VBD cord-015021-pol2qm74 7243 8 significantly significantly RB cord-015021-pol2qm74 7243 9 between between IN cord-015021-pol2qm74 7243 10 the the DT cord-015021-pol2qm74 7243 11 groups group NNS cord-015021-pol2qm74 7243 12 for for IN cord-015021-pol2qm74 7243 13 the the DT cord-015021-pol2qm74 7243 14 whole whole JJ cord-015021-pol2qm74 7243 15 study study NN cord-015021-pol2qm74 7243 16 period period NN cord-015021-pol2qm74 7243 17 , , , cord-015021-pol2qm74 7243 18 but but CC cord-015021-pol2qm74 7243 19 not not RB cord-015021-pol2qm74 7243 20 IGF2 IGF2 NNP cord-015021-pol2qm74 7243 21 and and CC cord-015021-pol2qm74 7243 22 IGFBP-3 IGFBP-3 NNP cord-015021-pol2qm74 7243 23 . . . cord-015021-pol2qm74 7244 1 The the DT cord-015021-pol2qm74 7244 2 circadian circadian JJ cord-015021-pol2qm74 7244 3 rhythm rhythm NN cord-015021-pol2qm74 7244 4 of of IN cord-015021-pol2qm74 7244 5 endogenous endogenous JJ cord-015021-pol2qm74 7244 6 GH gh NN cord-015021-pol2qm74 7244 7 - - HYPH cord-015021-pol2qm74 7244 8 excretion excretion NN cord-015021-pol2qm74 7244 9 had have VBD cord-015021-pol2qm74 7244 10 not not RB cord-015021-pol2qm74 7244 11 been be VBN cord-015021-pol2qm74 7244 12 altered alter VBN cord-015021-pol2qm74 7244 13 by by IN cord-015021-pol2qm74 7244 14 GH GH NNP cord-015021-pol2qm74 7244 15 , , , cord-015021-pol2qm74 7244 16 but but CC cord-015021-pol2qm74 7244 17 absolute absolute JJ cord-015021-pol2qm74 7244 18 levels level NNS cord-015021-pol2qm74 7244 19 of of IN cord-015021-pol2qm74 7244 20 GH GH NNP cord-015021-pol2qm74 7244 21 were be VBD cord-015021-pol2qm74 7244 22 increased increase VBN cord-015021-pol2qm74 7244 23 . . . cord-015021-pol2qm74 7245 1 Conclusion conclusion NN cord-015021-pol2qm74 7245 2 : : : cord-015021-pol2qm74 7245 3 During during IN cord-015021-pol2qm74 7245 4 the the DT cord-015021-pol2qm74 7245 5 first first JJ cord-015021-pol2qm74 7245 6 4 4 CD cord-015021-pol2qm74 7245 7 days day NNS cord-015021-pol2qm74 7245 8 after after IN cord-015021-pol2qm74 7245 9 OLTx OLTx NNS cord-015021-pol2qm74 7245 10 we -PRON- PRP cord-015021-pol2qm74 7245 11 could could MD cord-015021-pol2qm74 7245 12 proof proof VB cord-015021-pol2qm74 7245 13 the the DT cord-015021-pol2qm74 7245 14 protein protein NN cord-015021-pol2qm74 7245 15 sparing spare VBG cord-015021-pol2qm74 7245 16 effect effect NN cord-015021-pol2qm74 7245 17 of of IN cord-015021-pol2qm74 7245 18 GH GH NNP cord-015021-pol2qm74 7245 19 treatment treatment NN cord-015021-pol2qm74 7245 20 . . . cord-015021-pol2qm74 7246 1 Although although IN cord-015021-pol2qm74 7246 2 the the DT cord-015021-pol2qm74 7246 3 differences difference NNS cord-015021-pol2qm74 7246 4 between between IN cord-015021-pol2qm74 7246 5 the the DT cord-015021-pol2qm74 7246 6 two two CD cord-015021-pol2qm74 7246 7 groups group NNS cord-015021-pol2qm74 7246 8 were be VBD cord-015021-pol2qm74 7246 9 not not RB cord-015021-pol2qm74 7246 10 significantly significantly RB cord-015021-pol2qm74 7246 11 different different JJ cord-015021-pol2qm74 7246 12 for for IN cord-015021-pol2qm74 7246 13 the the DT cord-015021-pol2qm74 7246 14 whole whole JJ cord-015021-pol2qm74 7246 15 study study NN cord-015021-pol2qm74 7246 16 period period NN cord-015021-pol2qm74 7246 17 the the DT cord-015021-pol2qm74 7246 18 results result NNS cord-015021-pol2qm74 7246 19 showed show VBD cord-015021-pol2qm74 7246 20 on on IN cord-015021-pol2qm74 7246 21 all all DT cord-015021-pol2qm74 7246 22 days day NNS cord-015021-pol2qm74 7246 23 a a DT cord-015021-pol2qm74 7246 24 less less RBR cord-015021-pol2qm74 7246 25 catabolic catabolic JJ cord-015021-pol2qm74 7246 26 situation situation NN cord-015021-pol2qm74 7246 27 for for IN cord-015021-pol2qm74 7246 28 the the DT cord-015021-pol2qm74 7246 29 rhGH rhgh NN cord-015021-pol2qm74 7246 30 treated treat VBD cord-015021-pol2qm74 7246 31 patients patient NNS cord-015021-pol2qm74 7246 32 . . . cord-015021-pol2qm74 7247 1 To to TO cord-015021-pol2qm74 7247 2 possibly possibly RB cord-015021-pol2qm74 7247 3 improve improve VB cord-015021-pol2qm74 7247 4 protein protein NN cord-015021-pol2qm74 7247 5 balance balance NN cord-015021-pol2qm74 7247 6 after after IN cord-015021-pol2qm74 7247 7 major major JJ cord-015021-pol2qm74 7247 8 abdominal abdominal JJ cord-015021-pol2qm74 7247 9 surgery surgery NN cord-015021-pol2qm74 7247 10 we -PRON- PRP cord-015021-pol2qm74 7247 11 studied study VBD cord-015021-pol2qm74 7247 12 the the DT cord-015021-pol2qm74 7247 13 effects effect NNS cord-015021-pol2qm74 7247 14 of of IN cord-015021-pol2qm74 7247 15 GH GH NNP cord-015021-pol2qm74 7247 16 on on IN cord-015021-pol2qm74 7247 17 protein protein NN cord-015021-pol2qm74 7247 18 metabolism metabolism NN cord-015021-pol2qm74 7247 19 after after IN cord-015021-pol2qm74 7247 20 LTX LTX NNP cord-015021-pol2qm74 7247 21 . . . cord-015021-pol2qm74 7248 1 Excluding exclude VBG cord-015021-pol2qm74 7248 2 malignant malignant JJ cord-015021-pol2qm74 7248 3 diseases disease NNS cord-015021-pol2qm74 7248 4 , , , cord-015021-pol2qm74 7248 5 29 29 CD cord-015021-pol2qm74 7248 6 candidates candidate NNS cord-015021-pol2qm74 7248 7 for for IN cord-015021-pol2qm74 7248 8 LTX LTX NNP cord-015021-pol2qm74 7248 9 were be VBD cord-015021-pol2qm74 7248 10 randomized randomize VBN cord-015021-pol2qm74 7248 11 to to IN cord-015021-pol2qm74 7248 12 either either DT cord-015021-pol2qm74 7248 13 postoperatively postoperatively RB cord-015021-pol2qm74 7248 14 receive receive VB cord-015021-pol2qm74 7248 15 the the DT cord-015021-pol2qm74 7248 16 usual usual JJ cord-015021-pol2qm74 7248 17 treatment treatment NN cord-015021-pol2qm74 7248 18 ( ( -LRB- cord-015021-pol2qm74 7248 19 CO co NN cord-015021-pol2qm74 7248 20 = = SYM cord-015021-pol2qm74 7248 21 control control NN cord-015021-pol2qm74 7248 22 group group NN cord-015021-pol2qm74 7248 23 , , , cord-015021-pol2qm74 7248 24 N=14 N=14 NNP cord-015021-pol2qm74 7248 25 , , , cord-015021-pol2qm74 7248 26 age age NN cord-015021-pol2qm74 7248 27 range range VBP cord-015021-pol2qm74 7248 28 25 25 CD cord-015021-pol2qm74 7248 29 - - SYM cord-015021-pol2qm74 7248 30 59 59 CD cord-015021-pol2qm74 7248 31 yr yr NN cord-015021-pol2qm74 7248 32 , , , cord-015021-pol2qm74 7248 33 BMI BMI NNP cord-015021-pol2qm74 7248 34 23.9 23.9 CD cord-015021-pol2qm74 7248 35 + + CC cord-015021-pol2qm74 7249 1 5.7 5.7 CD cord-015021-pol2qm74 7249 2 kg kg NNS cord-015021-pol2qm74 7249 3 / / SYM cord-015021-pol2qm74 7249 4 m m NN cord-015021-pol2qm74 7249 5 2 2 CD cord-015021-pol2qm74 7249 6 ) ) -RRB- cord-015021-pol2qm74 7249 7 or or CC cord-015021-pol2qm74 7249 8 for for IN cord-015021-pol2qm74 7249 9 14 14 CD cord-015021-pol2qm74 7249 10 days day NNS cord-015021-pol2qm74 7249 11 additional additional JJ cord-015021-pol2qm74 7249 12 GH GH NNP cord-015021-pol2qm74 7249 13 ( ( -LRB- cord-015021-pol2qm74 7249 14 2x8 2x8 CD cord-015021-pol2qm74 7249 15 I.U.s.c I.U.s.c NNP cord-015021-pol2qm74 7249 16 . . . cord-015021-pol2qm74 7249 17 ) ) -RRB- cord-015021-pol2qm74 7250 1 ( ( -LRB- cord-015021-pol2qm74 7250 2 GH GH NNP cord-015021-pol2qm74 7250 3 group group NN cord-015021-pol2qm74 7250 4 , , , cord-015021-pol2qm74 7250 5 N=14 N=14 NNP cord-015021-pol2qm74 7250 6 , , , cord-015021-pol2qm74 7250 7 21 21 CD cord-015021-pol2qm74 7250 8 - - SYM cord-015021-pol2qm74 7250 9 59 59 CD cord-015021-pol2qm74 7250 10 yr yr NN cord-015021-pol2qm74 7250 11 , , , cord-015021-pol2qm74 7250 12 21.8 21.8 CD cord-015021-pol2qm74 7250 13 + + SYM cord-015021-pol2qm74 7250 14 2.2 2.2 CD cord-015021-pol2qm74 7250 15 kg kg NN cord-015021-pol2qm74 7250 16 / / SYM cord-015021-pol2qm74 7250 17 m2 m2 NNP cord-015021-pol2qm74 7250 18 ) ) -RRB- cord-015021-pol2qm74 7250 19 . . . cord-015021-pol2qm74 7251 1 Metabolic metabolic JJ cord-015021-pol2qm74 7251 2 studies study NNS cord-015021-pol2qm74 7251 3 ( ( -LRB- cord-015021-pol2qm74 7251 4 calorimetry calorimetry NN cord-015021-pol2qm74 7251 5 and and CC cord-015021-pol2qm74 7251 6 lsC lsc JJ cord-015021-pol2qm74 7251 7 - - HYPH cord-015021-pol2qm74 7251 8 leucine leucine NN cord-015021-pol2qm74 7251 9 infusion infusion NN cord-015021-pol2qm74 7251 10 ) ) -RRB- cord-015021-pol2qm74 7251 11 were be VBD cord-015021-pol2qm74 7251 12 performed perform VBN cord-015021-pol2qm74 7251 13 5 5 CD cord-015021-pol2qm74 7251 14 ( ( -LRB- cord-015021-pol2qm74 7251 15 test test VB cord-015021-pol2qm74 7251 16 A a NN cord-015021-pol2qm74 7251 17 ) ) -RRB- cord-015021-pol2qm74 7251 18 and and CC cord-015021-pol2qm74 7251 19 11 11 CD cord-015021-pol2qm74 7251 20 days day NNS cord-015021-pol2qm74 7251 21 ( ( -LRB- cord-015021-pol2qm74 7251 22 test test NN cord-015021-pol2qm74 7251 23 B b NN cord-015021-pol2qm74 7251 24 ) ) -RRB- cord-015021-pol2qm74 7251 25 after after IN cord-015021-pol2qm74 7251 26 surgery surgery NN cord-015021-pol2qm74 7251 27 . . . cord-015021-pol2qm74 7252 1 Tracer tracer NN cord-015021-pol2qm74 7252 2 analysis analysis NN cord-015021-pol2qm74 7252 3 was be VBD cord-015021-pol2qm74 7252 4 done do VBN cord-015021-pol2qm74 7252 5 by by IN cord-015021-pol2qm74 7252 6 gas gas NN cord-015021-pol2qm74 7252 7 chromatography chromatography NN cord-015021-pol2qm74 7252 8 - - HYPH cord-015021-pol2qm74 7252 9 mass mass NN cord-015021-pol2qm74 7252 10 spectrometry spectrometry NN cord-015021-pol2qm74 7252 11 . . . cord-015021-pol2qm74 7253 1 During during IN cord-015021-pol2qm74 7253 2 the the DT cord-015021-pol2qm74 7253 3 2-week 2-week CD cord-015021-pol2qm74 7253 4 study study NN cord-015021-pol2qm74 7253 5 clinical clinical JJ cord-015021-pol2qm74 7253 6 parameters parameter NNS cord-015021-pol2qm74 7253 7 did do VBD cord-015021-pol2qm74 7253 8 not not RB cord-015021-pol2qm74 7253 9 differ differ VB cord-015021-pol2qm74 7253 10 significantly significantly RB cord-015021-pol2qm74 7253 11 between between IN cord-015021-pol2qm74 7253 12 groups group NNS cord-015021-pol2qm74 7253 13 ; ; : cord-015021-pol2qm74 7253 14 however however RB cord-015021-pol2qm74 7253 15 , , , cord-015021-pol2qm74 7253 16 there there EX cord-015021-pol2qm74 7253 17 was be VBD cord-015021-pol2qm74 7253 18 a a DT cord-015021-pol2qm74 7253 19 tendency tendency NN cord-015021-pol2qm74 7253 20 for for IN cord-015021-pol2qm74 7253 21 increased increase VBN cord-015021-pol2qm74 7253 22 glucose glucose NN cord-015021-pol2qm74 7253 23 levels level NNS cord-015021-pol2qm74 7253 24 , , , cord-015021-pol2qm74 7253 25 insulin insulin NN cord-015021-pol2qm74 7253 26 need need NN cord-015021-pol2qm74 7253 27 , , , cord-015021-pol2qm74 7253 28 and and CC cord-015021-pol2qm74 7253 29 energy energy NN cord-015021-pol2qm74 7253 30 expenditure expenditure NN cord-015021-pol2qm74 7253 31 at at IN cord-015021-pol2qm74 7253 32 the the DT cord-015021-pol2qm74 7253 33 time time NN cord-015021-pol2qm74 7253 34 of of IN cord-015021-pol2qm74 7253 35 test test NN cord-015021-pol2qm74 7253 36 B b NN cord-015021-pol2qm74 7253 37 in in IN cord-015021-pol2qm74 7253 38 the the DT cord-015021-pol2qm74 7253 39 GH GH NNP cord-015021-pol2qm74 7253 40 group group NN cord-015021-pol2qm74 7253 41 . . . cord-015021-pol2qm74 7254 1 Leucine leucine NN cord-015021-pol2qm74 7254 2 oxidation oxidation NN cord-015021-pol2qm74 7254 3 ( ( -LRB- cord-015021-pol2qm74 7254 4 X+SE X+SE NNP cord-015021-pol2qm74 7254 5 ) ) -RRB- cord-015021-pol2qm74 7254 6 during during IN cord-015021-pol2qm74 7254 7 test test NN cord-015021-pol2qm74 7254 8 A;B a;b NN cord-015021-pol2qm74 7254 9 was be VBD cord-015021-pol2qm74 7254 10 117 117 CD cord-015021-pol2qm74 7254 11 + + SYM cord-015021-pol2qm74 7254 12 10 10 CD cord-015021-pol2qm74 7254 13 ; ; : cord-015021-pol2qm74 7254 14 111 111 CD cord-015021-pol2qm74 7254 15 + + SYM cord-015021-pol2qm74 7254 16 15 15 CD cord-015021-pol2qm74 7254 17 ( ( -LRB- cord-015021-pol2qm74 7254 18 CO CO NNP cord-015021-pol2qm74 7254 19 ) ) -RRB- cord-015021-pol2qm74 7254 20 and and CC cord-015021-pol2qm74 7254 21 110 110 CD cord-015021-pol2qm74 7254 22 + + SYM cord-015021-pol2qm74 7254 23 7 7 CD cord-015021-pol2qm74 7254 24 ; ; : cord-015021-pol2qm74 7254 25 100±12 100±12 CD cord-015021-pol2qm74 7254 26 ( ( -LRB- cord-015021-pol2qm74 7254 27 GH GH NNP cord-015021-pol2qm74 7254 28 ) ) -RRB- cord-015021-pol2qm74 7254 29 pMol pmol NN cord-015021-pol2qm74 7254 30 / / SYM cord-015021-pol2qm74 7254 31 kg kg NN cord-015021-pol2qm74 7254 32 FFM FFM NNP cord-015021-pol2qm74 7254 33 / / SYM cord-015021-pol2qm74 7254 34 h h NNP cord-015021-pol2qm74 7254 35 ( ( -LRB- cord-015021-pol2qm74 7254 36 n.s n.s NNP cord-015021-pol2qm74 7254 37 . . NNP cord-015021-pol2qm74 7254 38 ) ) -RRB- cord-015021-pol2qm74 7254 39 . . . cord-015021-pol2qm74 7255 1 Protein protein NN cord-015021-pol2qm74 7255 2 breakdown breakdown NN cord-015021-pol2qm74 7255 3 was be VBD cord-015021-pol2qm74 7255 4 134±16 134±16 CD cord-015021-pol2qm74 7255 5 ; ; : cord-015021-pol2qm74 7255 6 131 131 CD cord-015021-pol2qm74 7255 7 + + SYM cord-015021-pol2qm74 7255 8 30 30 CD cord-015021-pol2qm74 7255 9 ( ( -LRB- cord-015021-pol2qm74 7255 10 CO CO NNP cord-015021-pol2qm74 7255 11 ) ) -RRB- cord-015021-pol2qm74 7255 12 and and CC cord-015021-pol2qm74 7255 13 156 156 CD cord-015021-pol2qm74 7255 14 + + SYM cord-015021-pol2qm74 7255 15 14 14 CD cord-015021-pol2qm74 7255 16 ; ; : cord-015021-pol2qm74 7255 17 178 178 CD cord-015021-pol2qm74 7255 18 + + SYM cord-015021-pol2qm74 7255 19 30 30 CD cord-015021-pol2qm74 7256 1 ( ( -LRB- cord-015021-pol2qm74 7256 2 GH GH NNP cord-015021-pol2qm74 7256 3 ) ) -RRB- cord-015021-pol2qm74 7256 4 pMol pmol NN cord-015021-pol2qm74 7256 5 / / SYM cord-015021-pol2qm74 7256 6 kg kg NN cord-015021-pol2qm74 7256 7 FFM FFM NNP cord-015021-pol2qm74 7256 8 / / SYM cord-015021-pol2qm74 7256 9 h h NNP cord-015021-pol2qm74 7256 10 ( ( -LRB- cord-015021-pol2qm74 7256 11 n.s n.s NNP cord-015021-pol2qm74 7256 12 . . NNP cord-015021-pol2qm74 7256 13 ) ) -RRB- cord-015021-pol2qm74 7256 14 . . . cord-015021-pol2qm74 7257 1 Nonoxidative nonoxidative JJ cord-015021-pol2qm74 7257 2 - - HYPH cord-015021-pol2qm74 7257 3 leuine leuine NN cord-015021-pol2qm74 7257 4 disposal disposal NN cord-015021-pol2qm74 7257 5 was be VBD cord-015021-pol2qm74 7257 6 119±9 119±9 CD cord-015021-pol2qm74 7257 7 ; ; : cord-015021-pol2qm74 7257 8 127 127 CD cord-015021-pol2qm74 7257 9 + + SYM cord-015021-pol2qm74 7257 10 16 16 CD cord-015021-pol2qm74 7257 11 ( ( -LRB- cord-015021-pol2qm74 7257 12 CO CO NNP cord-015021-pol2qm74 7257 13 ) ) -RRB- cord-015021-pol2qm74 7257 14 and and CC cord-015021-pol2qm74 7257 15 139±11 139±11 CD cord-015021-pol2qm74 7257 16 ; ; : cord-015021-pol2qm74 7257 17 177 177 CD cord-015021-pol2qm74 7257 18 + + SYM cord-015021-pol2qm74 7257 19 20 20 CD cord-015021-pol2qm74 7257 20 ( ( -LRB- cord-015021-pol2qm74 7257 21 GH GH NNP cord-015021-pol2qm74 7257 22 ) ) -RRB- cord-015021-pol2qm74 7257 23 pMol pmol NN cord-015021-pol2qm74 7257 24 / / SYM cord-015021-pol2qm74 7257 25 kg kg NN cord-015021-pol2qm74 7257 26 FFM FFM NNP cord-015021-pol2qm74 7257 27 / / SYM cord-015021-pol2qm74 7257 28 h h NN cord-015021-pol2qm74 7257 29 ( ( -LRB- cord-015021-pol2qm74 7257 30 p<0.05 p<0.05 NNP cord-015021-pol2qm74 7257 31 for for IN cord-015021-pol2qm74 7257 32 the the DT cord-015021-pol2qm74 7257 33 rise rise NN cord-015021-pol2qm74 7257 34 in in IN cord-015021-pol2qm74 7257 35 the the DT cord-015021-pol2qm74 7257 36 GH GH NNP cord-015021-pol2qm74 7257 37 group group NN cord-015021-pol2qm74 7257 38 ) ) -RRB- cord-015021-pol2qm74 7257 39 . . . cord-015021-pol2qm74 7258 1 Tracer tracer NN cord-015021-pol2qm74 7258 2 data datum NNS cord-015021-pol2qm74 7258 3 were be VBD cord-015021-pol2qm74 7258 4 supported support VBN cord-015021-pol2qm74 7258 5 by by IN cord-015021-pol2qm74 7258 6 cumulative cumulative JJ cord-015021-pol2qm74 7258 7 urea urea NN cord-015021-pol2qm74 7258 8 nitrogen nitrogen NN cord-015021-pol2qm74 7258 9 excretion excretion NN cord-015021-pol2qm74 7258 10 ( ( -LRB- cord-015021-pol2qm74 7258 11 days day NNS cord-015021-pol2qm74 7258 12 1 1 CD cord-015021-pol2qm74 7258 13 - - SYM cord-015021-pol2qm74 7258 14 4 4 CD cord-015021-pol2qm74 7258 15 : : : cord-015021-pol2qm74 7258 16 GH GH NNP cord-015021-pol2qm74 7258 17 52 52 CD cord-015021-pol2qm74 7258 18 + + SYM cord-015021-pol2qm74 7258 19 3 3 CD cord-015021-pol2qm74 7258 20 vs vs IN cord-015021-pol2qm74 7258 21 CO CO NNP cord-015021-pol2qm74 7258 22 66±7 66±7 CD cord-015021-pol2qm74 7258 23 g g NN cord-015021-pol2qm74 7258 24 ; ; : cord-015021-pol2qm74 7258 25 p<0.05 p<0.05 NNP cord-015021-pol2qm74 7258 26 ) ) -RRB- cord-015021-pol2qm74 7258 27 . . . cord-015021-pol2qm74 7259 1 We -PRON- PRP cord-015021-pol2qm74 7259 2 conclude conclude VBP cord-015021-pol2qm74 7259 3 that that IN cord-015021-pol2qm74 7259 4 after after IN cord-015021-pol2qm74 7259 5 major major JJ cord-015021-pol2qm74 7259 6 abdominal abdominal JJ cord-015021-pol2qm74 7259 7 surgery surgery NN cord-015021-pol2qm74 7259 8 GH GH NNP cord-015021-pol2qm74 7259 9 lowers lower VBZ cord-015021-pol2qm74 7259 10 nitrogen nitrogen NN cord-015021-pol2qm74 7259 11 excretion excretion NN cord-015021-pol2qm74 7259 12 by by IN cord-015021-pol2qm74 7259 13 increasing increase VBG cord-015021-pol2qm74 7259 14 total total JJ cord-015021-pol2qm74 7259 15 body body NN cord-015021-pol2qm74 7259 16 protein protein NN cord-015021-pol2qm74 7259 17 synthesis synthesis NN cord-015021-pol2qm74 7259 18 . . . cord-015021-pol2qm74 7260 1 It -PRON- PRP cord-015021-pol2qm74 7260 2 is be VBZ cord-015021-pol2qm74 7260 3 not not RB cord-015021-pol2qm74 7260 4 known know VBN cord-015021-pol2qm74 7260 5 which which WDT cord-015021-pol2qm74 7260 6 organs organ NNS cord-015021-pol2qm74 7260 7 contribute contribute VBP cord-015021-pol2qm74 7260 8 to to IN cord-015021-pol2qm74 7260 9 this this DT cord-015021-pol2qm74 7260 10 effect effect NN cord-015021-pol2qm74 7260 11 . . . cord-015021-pol2qm74 7261 1 In in IN cord-015021-pol2qm74 7261 2 several several JJ cord-015021-pol2qm74 7261 3 investigations investigation NNS cord-015021-pol2qm74 7261 4 it -PRON- PRP cord-015021-pol2qm74 7261 5 has have VBZ cord-015021-pol2qm74 7261 6 been be VBN cord-015021-pol2qm74 7261 7 shown show VBN cord-015021-pol2qm74 7261 8 that that IN cord-015021-pol2qm74 7261 9 the the DT cord-015021-pol2qm74 7261 10 protein protein NN cord-015021-pol2qm74 7261 11 saving saving NN cord-015021-pol2qm74 7261 12 effect effect NN cord-015021-pol2qm74 7261 13 of of IN cord-015021-pol2qm74 7261 14 recombinant recombinant JJ cord-015021-pol2qm74 7261 15 human human JJ cord-015021-pol2qm74 7261 16 Growth Growth NNP cord-015021-pol2qm74 7261 17 Hormone Hormone NNP cord-015021-pol2qm74 7261 18 ( ( -LRB- cord-015021-pol2qm74 7261 19 rhGH rhGH NNP cord-015021-pol2qm74 7261 20 ) ) -RRB- cord-015021-pol2qm74 7261 21 in in IN cord-015021-pol2qm74 7261 22 the the DT cord-015021-pol2qm74 7261 23 postoperative postoperative JJ cord-015021-pol2qm74 7261 24 state state NN cord-015021-pol2qm74 7261 25 is be VBZ cord-015021-pol2qm74 7261 26 accompanied accompany VBN cord-015021-pol2qm74 7261 27 by by IN cord-015021-pol2qm74 7261 28 raised raise VBN cord-015021-pol2qm74 7261 29 IGF-1 IGF-1 NNP cord-015021-pol2qm74 7261 30 levels level NNS cord-015021-pol2qm74 7261 31 in in IN cord-015021-pol2qm74 7261 32 plasma plasma NN cord-015021-pol2qm74 7261 33 . . . cord-015021-pol2qm74 7262 1 It -PRON- PRP cord-015021-pol2qm74 7262 2 was be VBD cord-015021-pol2qm74 7262 3 concluded conclude VBN cord-015021-pol2qm74 7262 4 that that IN cord-015021-pol2qm74 7262 5 the the DT cord-015021-pol2qm74 7262 6 anabolic anabolic JJ cord-015021-pol2qm74 7262 7 effects effect NNS cord-015021-pol2qm74 7262 8 of of IN cord-015021-pol2qm74 7262 9 rhGH rhgh NN cord-015021-pol2qm74 7262 10 were be VBD cord-015021-pol2qm74 7262 11 probably probably RB cord-015021-pol2qm74 7262 12 , , , cord-015021-pol2qm74 7262 13 at at IN cord-015021-pol2qm74 7262 14 least least JJS cord-015021-pol2qm74 7262 15 in in IN cord-015021-pol2qm74 7262 16 part part NN cord-015021-pol2qm74 7262 17 , , , cord-015021-pol2qm74 7262 18 mediated mediate VBN cord-015021-pol2qm74 7262 19 by by IN cord-015021-pol2qm74 7262 20 IGF-1 IGF-1 NNP cord-015021-pol2qm74 7262 21 . . . cord-015021-pol2qm74 7263 1 This this DT cord-015021-pol2qm74 7263 2 study study NN cord-015021-pol2qm74 7263 3 was be VBD cord-015021-pol2qm74 7263 4 aimed aim VBN cord-015021-pol2qm74 7263 5 at at IN cord-015021-pol2qm74 7263 6 detecting detect VBG cord-015021-pol2qm74 7263 7 the the DT cord-015021-pol2qm74 7263 8 efficacy efficacy NN cord-015021-pol2qm74 7263 9 of of IN cord-015021-pol2qm74 7263 10 IGF IGF NNP cord-015021-pol2qm74 7263 11 - - : cord-015021-pol2qm74 7263 12 I -PRON- PRP cord-015021-pol2qm74 7263 13 on on IN cord-015021-pol2qm74 7263 14 modulation modulation NN cord-015021-pol2qm74 7263 15 of of IN cord-015021-pol2qm74 7263 16 the the DT cord-015021-pol2qm74 7263 17 protein protein NN cord-015021-pol2qm74 7263 18 metabolism metabolism NN cord-015021-pol2qm74 7263 19 in in IN cord-015021-pol2qm74 7263 20 the the DT cord-015021-pol2qm74 7263 21 catabolic catabolic JJ cord-015021-pol2qm74 7263 22 state state NN cord-015021-pol2qm74 7263 23 . . . cord-015021-pol2qm74 7264 1 Patients patient NNS cord-015021-pol2qm74 7264 2 and and CC cord-015021-pol2qm74 7264 3 Methodes Methodes NNP cord-015021-pol2qm74 7264 4 : : : cord-015021-pol2qm74 7264 5 38 38 CD cord-015021-pol2qm74 7264 6 patients patient NNS cord-015021-pol2qm74 7264 7 ( ( -LRB- cord-015021-pol2qm74 7264 8 both both DT cord-015021-pol2qm74 7264 9 sexes sex NNS cord-015021-pol2qm74 7264 10 , , , cord-015021-pol2qm74 7264 11 age age NN cord-015021-pol2qm74 7264 12 : : : cord-015021-pol2qm74 7264 13 40 40 CD cord-015021-pol2qm74 7264 14 - - SYM cord-015021-pol2qm74 7264 15 75 75 CD cord-015021-pol2qm74 7264 16 years year NNS cord-015021-pol2qm74 7264 17 , , , cord-015021-pol2qm74 7264 18 BMI BMI NNP cord-015021-pol2qm74 7264 19 17 17 CD cord-015021-pol2qm74 7264 20 - - SYM cord-015021-pol2qm74 7264 21 30 30 CD cord-015021-pol2qm74 7264 22 kg kg NN cord-015021-pol2qm74 7264 23 / / SYM cord-015021-pol2qm74 7264 24 m m NN cord-015021-pol2qm74 7264 25 2 2 CD cord-015021-pol2qm74 7264 26 ) ) -RRB- cord-015021-pol2qm74 7264 27 with with IN cord-015021-pol2qm74 7264 28 major major JJ cord-015021-pol2qm74 7264 29 upper upper JJ cord-015021-pol2qm74 7264 30 gastrointestinal gastrointestinal JJ cord-015021-pol2qm74 7264 31 surgery surgery NN cord-015021-pol2qm74 7264 32 ( ( -LRB- cord-015021-pol2qm74 7264 33 gastrectomy gastrectomy NN cord-015021-pol2qm74 7264 34 or or CC cord-015021-pol2qm74 7264 35 partial partial JJ cord-015021-pol2qm74 7264 36 gastrectomy gastrectomy NN cord-015021-pol2qm74 7264 37 ) ) -RRB- cord-015021-pol2qm74 7264 38 received receive VBD cord-015021-pol2qm74 7264 39 80 80 CD cord-015021-pol2qm74 7264 40 ug ug NNP cord-015021-pol2qm74 7264 41 rhlGF-1 rhlGF-1 NNP cord-015021-pol2qm74 7264 42 / / SYM cord-015021-pol2qm74 7264 43 kg kg NN cord-015021-pol2qm74 7264 44 body body NN cord-015021-pol2qm74 7264 45 weight weight NN cord-015021-pol2qm74 7264 46 / / SYM cord-015021-pol2qm74 7264 47 twice twice RB cord-015021-pol2qm74 7264 48 daily daily JJ cord-015021-pol2qm74 7264 49 or or CC cord-015021-pol2qm74 7264 50 placebo placebo NN cord-015021-pol2qm74 7264 51 during during IN cord-015021-pol2qm74 7264 52 5 5 CD cord-015021-pol2qm74 7264 53 treatment treatment NN cord-015021-pol2qm74 7264 54 days day NNS cord-015021-pol2qm74 7264 55 beginning begin VBG cord-015021-pol2qm74 7264 56 on on IN cord-015021-pol2qm74 7264 57 the the DT cord-015021-pol2qm74 7264 58 first first JJ cord-015021-pol2qm74 7264 59 postoperative postoperative JJ cord-015021-pol2qm74 7264 60 day day NN cord-015021-pol2qm74 7264 61 in in IN cord-015021-pol2qm74 7264 62 a a DT cord-015021-pol2qm74 7264 63 double double JJ cord-015021-pol2qm74 7264 64 - - HYPH cord-015021-pol2qm74 7264 65 blind blind JJ cord-015021-pol2qm74 7264 66 , , , cord-015021-pol2qm74 7264 67 randomized randomized JJ cord-015021-pol2qm74 7264 68 study study NN cord-015021-pol2qm74 7264 69 . . . cord-015021-pol2qm74 7265 1 All all DT cord-015021-pol2qm74 7265 2 patients patient NNS cord-015021-pol2qm74 7265 3 received receive VBD cord-015021-pol2qm74 7265 4 hypocaloric hypocaloric JJ cord-015021-pol2qm74 7265 5 and and CC cord-015021-pol2qm74 7265 6 hyponitrogenous hyponitrogenous JJ cord-015021-pol2qm74 7265 7 total total JJ cord-015021-pol2qm74 7265 8 parenteral parenteral JJ cord-015021-pol2qm74 7265 9 nutrition nutrition NN cord-015021-pol2qm74 7265 10 ( ( -LRB- cord-015021-pol2qm74 7265 11 3 3 CD cord-015021-pol2qm74 7265 12 g g NN cord-015021-pol2qm74 7265 13 CHNg CHNg NNS cord-015021-pol2qm74 7265 14 , , , cord-015021-pol2qm74 7265 15 O.6 O.6 NNP cord-015021-pol2qm74 7265 16 g g NNP cord-015021-pol2qm74 7265 17 AA AA NNP cord-015021-pol2qm74 7265 18 / / SYM cord-015021-pol2qm74 7265 19 kg kg NN cord-015021-pol2qm74 7265 20 ) ) -RRB- cord-015021-pol2qm74 7266 1 troughout troughout NNP cord-015021-pol2qm74 7266 2 the the DT cord-015021-pol2qm74 7266 3 whole whole JJ cord-015021-pol2qm74 7266 4 study study NN cord-015021-pol2qm74 7266 5 period period NN cord-015021-pol2qm74 7266 6 . . . cord-015021-pol2qm74 7267 1 Cumulated cumulated JJ cord-015021-pol2qm74 7267 2 nitrogen nitrogen NN cord-015021-pol2qm74 7267 3 balance balance NN cord-015021-pol2qm74 7267 4 , , , cord-015021-pol2qm74 7267 5 3-methyl 3-methyl CD cord-015021-pol2qm74 7267 6 - - HYPH cord-015021-pol2qm74 7267 7 histidin histidin NNP cord-015021-pol2qm74 7267 8 exretion exretion NN cord-015021-pol2qm74 7267 9 in in IN cord-015021-pol2qm74 7267 10 urine urine NN cord-015021-pol2qm74 7267 11 as as RB cord-015021-pol2qm74 7267 12 well well RB cord-015021-pol2qm74 7267 13 as as IN cord-015021-pol2qm74 7267 14 Serum serum NN cord-015021-pol2qm74 7267 15 - - HYPH cord-015021-pol2qm74 7267 16 IGF-1 IGF-1 NNP cord-015021-pol2qm74 7267 17 levels level NNS cord-015021-pol2qm74 7267 18 have have VBP cord-015021-pol2qm74 7267 19 been be VBN cord-015021-pol2qm74 7267 20 determined determine VBN cord-015021-pol2qm74 7267 21 . . . cord-015021-pol2qm74 7268 1 The the DT cord-015021-pol2qm74 7268 2 two two CD cord-015021-pol2qm74 7268 3 tailed tailed JJ cord-015021-pol2qm74 7268 4 Wilcoxon Wilcoxon NNP cord-015021-pol2qm74 7268 5 test test NN cord-015021-pol2qm74 7268 6 was be VBD cord-015021-pol2qm74 7268 7 used use VBN cord-015021-pol2qm74 7268 8 for for IN cord-015021-pol2qm74 7268 9 statistical statistical JJ cord-015021-pol2qm74 7268 10 analysis analysis NN cord-015021-pol2qm74 7268 11 Results result NNS cord-015021-pol2qm74 7268 12 : : : cord-015021-pol2qm74 7268 13 first first JJ cord-015021-pol2qm74 7268 14 results result NNS cord-015021-pol2qm74 7268 15 will will MD cord-015021-pol2qm74 7268 16 be be VB cord-015021-pol2qm74 7268 17 presented present VBN cord-015021-pol2qm74 7269 1 Previous previous JJ cord-015021-pol2qm74 7269 2 studies study NNS cord-015021-pol2qm74 7269 3 have have VBP cord-015021-pol2qm74 7269 4 suggested suggest VBN cord-015021-pol2qm74 7269 5 that that IN cord-015021-pol2qm74 7269 6 growth growth NN cord-015021-pol2qm74 7269 7 hormone hormone NN cord-015021-pol2qm74 7269 8 ( ( -LRB- cord-015021-pol2qm74 7269 9 GH GH NNP cord-015021-pol2qm74 7269 10 ) ) -RRB- cord-015021-pol2qm74 7269 11 potentiates potentiate VBZ cord-015021-pol2qm74 7269 12 various various JJ cord-015021-pol2qm74 7269 13 activities activity NNS cord-015021-pol2qm74 7269 14 of of IN cord-015021-pol2qm74 7269 15 leukecytes leukecyte NNS cord-015021-pol2qm74 7269 16 . . . cord-015021-pol2qm74 7270 1 However however RB cord-015021-pol2qm74 7270 2 , , , cord-015021-pol2qm74 7270 3 it -PRON- PRP cord-015021-pol2qm74 7270 4 is be VBZ cord-015021-pol2qm74 7270 5 not not RB cord-015021-pol2qm74 7270 6 clear clear JJ cord-015021-pol2qm74 7270 7 whether whether IN cord-015021-pol2qm74 7270 8 GH GH NNP cord-015021-pol2qm74 7270 9 can can MD cord-015021-pol2qm74 7270 10 improve improve VB cord-015021-pol2qm74 7270 11 survival survival NN cord-015021-pol2qm74 7270 12 of of IN cord-015021-pol2qm74 7270 13 animals animal NNS cord-015021-pol2qm74 7270 14 with with IN cord-015021-pol2qm74 7270 15 gram gram JJ cord-015021-pol2qm74 7270 16 - - HYPH cord-015021-pol2qm74 7270 17 negative negative JJ cord-015021-pol2qm74 7270 18 sepsis sepsis NN cord-015021-pol2qm74 7270 19 . . . cord-015021-pol2qm74 7271 1 We -PRON- PRP cord-015021-pol2qm74 7271 2 investigated investigate VBD cord-015021-pol2qm74 7271 3 the the DT cord-015021-pol2qm74 7271 4 effects effect NNS cord-015021-pol2qm74 7271 5 of of IN cord-015021-pol2qm74 7271 6 GH GH NNP cord-015021-pol2qm74 7271 7 on on IN cord-015021-pol2qm74 7271 8 host host NN cord-015021-pol2qm74 7271 9 response response NN cord-015021-pol2qm74 7271 10 to to IN cord-015021-pol2qm74 7271 11 infection infection NN cord-015021-pol2qm74 7271 12 in in IN cord-015021-pol2qm74 7271 13 septic septic JJ cord-015021-pol2qm74 7271 14 mice mice NN cord-015021-pol2qm74 7271 15 model model NN cord-015021-pol2qm74 7271 16 . . . cord-015021-pol2qm74 7272 1 METHODS methods NN cord-015021-pol2qm74 7273 1 BALB]c BALB]c NNP cord-015021-pol2qm74 7273 2 mice mouse NNS cord-015021-pol2qm74 7273 3 were be VBD cord-015021-pol2qm74 7273 4 randomized randomize VBN cord-015021-pol2qm74 7273 5 to to IN cord-015021-pol2qm74 7273 6 3 3 CD cord-015021-pol2qm74 7273 7 groups group NNS cord-015021-pol2qm74 7273 8 ( ( -LRB- cord-015021-pol2qm74 7273 9 n=10 n=10 NNP cord-015021-pol2qm74 7273 10 / / SYM cord-015021-pol2qm74 7273 11 gronp gronp NNP cord-015021-pol2qm74 7273 12 ) ) -RRB- cord-015021-pol2qm74 7273 13 : : : cord-015021-pol2qm74 7273 14 GH gh NN cord-015021-pol2qm74 7273 15 - - HYPH cord-015021-pol2qm74 7273 16 high high NN cord-015021-pol2qm74 7273 17 ( ( -LRB- cord-015021-pol2qm74 7273 18 4 4 CD cord-015021-pol2qm74 7273 19 + + SYM cord-015021-pol2qm74 7273 20 8mg 8mg NNP cord-015021-pol2qm74 7273 21 / / SYM cord-015021-pol2qm74 7273 22 kg kg NN cord-015021-pol2qm74 7273 23 / / SYM cord-015021-pol2qm74 7273 24 day day NN cord-015021-pol2qm74 7273 25 ) ) -RRB- cord-015021-pol2qm74 7273 26 , , , cord-015021-pol2qm74 7273 27 GH GH NNP cord-015021-pol2qm74 7273 28 - - HYPH cord-015021-pol2qm74 7273 29 Iow Iow NNP cord-015021-pol2qm74 7273 30 ( ( -LRB- cord-015021-pol2qm74 7273 31 0A8mg 0a8mg CD cord-015021-pol2qm74 7273 32 / / SYM cord-015021-pol2qm74 7273 33 kg kg NN cord-015021-pol2qm74 7273 34 / / SYM cord-015021-pol2qm74 7273 35 day day NN cord-015021-pol2qm74 7273 36 ) ) -RRB- cord-015021-pol2qm74 7273 37 or or CC cord-015021-pol2qm74 7273 38 control control NN cord-015021-pol2qm74 7273 39 ( ( -LRB- cord-015021-pol2qm74 7273 40 saline saline NN cord-015021-pol2qm74 7273 41 ) ) -RRB- cord-015021-pol2qm74 7273 42 . . . cord-015021-pol2qm74 7274 1 Following follow VBG cord-015021-pol2qm74 7274 2 subcutaneous subcutaneous JJ cord-015021-pol2qm74 7274 3 treatment treatment NN cord-015021-pol2qm74 7274 4 ( ( -LRB- cord-015021-pol2qm74 7274 5 every every DT cord-015021-pol2qm74 7274 6 8 8 CD cord-015021-pol2qm74 7274 7 hours hour NNS cord-015021-pol2qm74 7274 8 for for IN cord-015021-pol2qm74 7274 9 6 6 CD cord-015021-pol2qm74 7274 10 days day NNS cord-015021-pol2qm74 7274 11 ) ) -RRB- cord-015021-pol2qm74 7274 12 with with IN cord-015021-pol2qm74 7274 13 GH GH NNP cord-015021-pol2qm74 7274 14 or or CC cord-015021-pol2qm74 7274 15 saline saline NN cord-015021-pol2qm74 7274 16 , , , cord-015021-pol2qm74 7274 17 mice mouse NNS cord-015021-pol2qm74 7274 18 were be VBD cord-015021-pol2qm74 7274 19 challenged challenge VBN cord-015021-pol2qm74 7274 20 i.p i.p NNP cord-015021-pol2qm74 7274 21 . . . cord-015021-pol2qm74 7275 1 with with IN cord-015021-pol2qm74 7275 2 E.coli E.coli NNS cord-015021-pol2qm74 7275 3 ( ( -LRB- cord-015021-pol2qm74 7275 4 lxl08 lxl08 CD cord-015021-pol2qm74 7275 5 / / SYM cord-015021-pol2qm74 7275 6 body body NN cord-015021-pol2qm74 7275 7 ) ) -RRB- cord-015021-pol2qm74 7275 8 . . . cord-015021-pol2qm74 7276 1 Survival survival NN cord-015021-pol2qm74 7276 2 rate rate NN cord-015021-pol2qm74 7276 3 was be VBD cord-015021-pol2qm74 7276 4 recorded record VBN cord-015021-pol2qm74 7276 5 every every DT cord-015021-pol2qm74 7276 6 2 2 CD cord-015021-pol2qm74 7276 7 hours hour NNS cord-015021-pol2qm74 7276 8 . . . cord-015021-pol2qm74 7277 1 In in IN cord-015021-pol2qm74 7277 2 the the DT cord-015021-pol2qm74 7277 3 next next JJ cord-015021-pol2qm74 7277 4 experiment experiment NN cord-015021-pol2qm74 7277 5 , , , cord-015021-pol2qm74 7277 6 GH gh NN cord-015021-pol2qm74 7277 7 - - HYPH cord-015021-pol2qm74 7277 8 high high JJ cord-015021-pol2qm74 7277 9 and and CC cord-015021-pol2qm74 7277 10 control control NN cord-015021-pol2qm74 7277 11 animals animal NNS cord-015021-pol2qm74 7277 12 were be VBD cord-015021-pol2qm74 7277 13 sacrificed sacrifice VBN cord-015021-pol2qm74 7277 14 4 4 CD cord-015021-pol2qm74 7277 15 hours hour NNS cord-015021-pol2qm74 7277 16 after after IN cord-015021-pol2qm74 7277 17 bacterial bacterial JJ cord-015021-pol2qm74 7277 18 challenge challenge NN cord-015021-pol2qm74 7277 19 . . . cord-015021-pol2qm74 7278 1 Peritoneal peritoneal JJ cord-015021-pol2qm74 7278 2 cavity cavity NN cord-015021-pol2qm74 7278 3 was be VBD cord-015021-pol2qm74 7278 4 lavaged lavage VBN cord-015021-pol2qm74 7278 5 with with IN cord-015021-pol2qm74 7278 6 3ml 3ml NN cord-015021-pol2qm74 7278 7 saline saline NN cord-015021-pol2qm74 7278 8 and and CC cord-015021-pol2qm74 7278 9 the the DT cord-015021-pol2qm74 7278 10 peritoneal peritoneal JJ cord-015021-pol2qm74 7278 11 exudative exudative JJ cord-015021-pol2qm74 7278 12 cells cell NNS cord-015021-pol2qm74 7278 13 ( ( -LRB- cord-015021-pol2qm74 7278 14 PEC PEC NNP cord-015021-pol2qm74 7278 15 ) ) -RRB- cord-015021-pol2qm74 7278 16 were be VBD cord-015021-pol2qm74 7278 17 harvested harvest VBN cord-015021-pol2qm74 7278 18 and and CC cord-015021-pol2qm74 7278 19 counted count VBN cord-015021-pol2qm74 7278 20 . . . cord-015021-pol2qm74 7279 1 Colony colony NN cord-015021-pol2qm74 7279 2 forming form VBG cord-015021-pol2qm74 7279 3 units unit NNS cord-015021-pol2qm74 7279 4 ( ( -LRB- cord-015021-pol2qm74 7279 5 CFU CFU NNP cord-015021-pol2qm74 7279 6 ) ) -RRB- cord-015021-pol2qm74 7279 7 of of IN cord-015021-pol2qm74 7279 8 bacteria bacteria NNS cord-015021-pol2qm74 7279 9 in in IN cord-015021-pol2qm74 7279 10 the the DT cord-015021-pol2qm74 7279 11 peritoneal peritoneal NN cord-015021-pol2qm74 7279 12 lavaged lavaged NN cord-015021-pol2qm74 7279 13 fluid fluid NN cord-015021-pol2qm74 7279 14 ( ( -LRB- cord-015021-pol2qm74 7279 15 PLF PLF NNP cord-015021-pol2qm74 7279 16 ) ) -RRB- cord-015021-pol2qm74 7279 17 , , , cord-015021-pol2qm74 7279 18 liver liver NN cord-015021-pol2qm74 7279 19 , , , cord-015021-pol2qm74 7279 20 lung lung NN cord-015021-pol2qm74 7279 21 and and CC cord-015021-pol2qm74 7279 22 blood blood NN cord-015021-pol2qm74 7279 23 were be VBD cord-015021-pol2qm74 7279 24 determined determine VBN cord-015021-pol2qm74 7279 25 . . . cord-015021-pol2qm74 7280 1 PEC PEC NNP cord-015021-pol2qm74 7280 2 were be VBD cord-015021-pol2qm74 7280 3 cultured culture VBN cord-015021-pol2qm74 7280 4 in in IN cord-015021-pol2qm74 7280 5 vitro vitro FW cord-015021-pol2qm74 7280 6 for for IN cord-015021-pol2qm74 7280 7 24 24 CD cord-015021-pol2qm74 7280 8 hours hour NNS cord-015021-pol2qm74 7280 9 with with IN cord-015021-pol2qm74 7280 10 lipopolymccharide lipopolymccharide NNP cord-015021-pol2qm74 7280 11 ( ( -LRB- cord-015021-pol2qm74 7280 12 10p.g 10p.g CD cord-015021-pol2qm74 7280 13 / / SYM cord-015021-pol2qm74 7280 14 ml ml NN cord-015021-pol2qm74 7281 1 In in IN cord-015021-pol2qm74 7281 2 normotensive normotensive JJ cord-015021-pol2qm74 7281 3 adults adult NNS cord-015021-pol2qm74 7281 4 growth growth NN cord-015021-pol2qm74 7281 5 hormone hormone NN cord-015021-pol2qm74 7281 6 ( ( -LRB- cord-015021-pol2qm74 7281 7 GH gh NN cord-015021-pol2qm74 7281 8 ) ) -RRB- cord-015021-pol2qm74 7281 9 rises rise VBZ cord-015021-pol2qm74 7281 10 when when WRB cord-015021-pol2qm74 7281 11 clonidine clonidine NN cord-015021-pol2qm74 7281 12 challenge challenge NN cord-015021-pol2qm74 7281 13 is be VBZ cord-015021-pol2qm74 7281 14 performed perform VBN cord-015021-pol2qm74 7281 15 . . . cord-015021-pol2qm74 7282 1 Recently recently RB cord-015021-pol2qm74 7282 2 evidence evidence NN cord-015021-pol2qm74 7282 3 was be VBD cord-015021-pol2qm74 7282 4 shown show VBN cord-015021-pol2qm74 7282 5 for for IN cord-015021-pol2qm74 7282 6 GH GH NNP cord-015021-pol2qm74 7282 7 to to TO cord-015021-pol2qm74 7282 8 accelerate accelerate VB cord-015021-pol2qm74 7282 9 wound wind VBN cord-015021-pol2qm74 7282 10 healing healing NN cord-015021-pol2qm74 7282 11 . . . cord-015021-pol2qm74 7283 1 While while IN cord-015021-pol2qm74 7283 2 GH gh NN cord-015021-pol2qm74 7283 3 secretion secretion NN cord-015021-pol2qm74 7283 4 patterns pattern NNS cord-015021-pol2qm74 7283 5 are be VBP cord-015021-pol2qm74 7283 6 inconstant inconstant JJ cord-015021-pol2qm74 7283 7 the the DT cord-015021-pol2qm74 7283 8 GH gh NN cord-015021-pol2qm74 7283 9 - - HYPH cord-015021-pol2qm74 7283 10 dependant dependant JJ cord-015021-pol2qm74 7283 11 insulin insulin NN cord-015021-pol2qm74 7283 12 like like IN cord-015021-pol2qm74 7283 13 growth growth NN cord-015021-pol2qm74 7283 14 factor factor NN cord-015021-pol2qm74 7283 15 ( ( -LRB- cord-015021-pol2qm74 7283 16 IGF-1 IGF-1 NNP cord-015021-pol2qm74 7283 17 ) ) -RRB- cord-015021-pol2qm74 7283 18 and and CC cord-015021-pol2qm74 7283 19 the the DT cord-015021-pol2qm74 7283 20 insulin insulin NN cord-015021-pol2qm74 7283 21 like like IN cord-015021-pol2qm74 7283 22 growth growth NN cord-015021-pol2qm74 7283 23 factor factor NN cord-015021-pol2qm74 7283 24 binding bind VBG cord-015021-pol2qm74 7283 25 protein protein NN cord-015021-pol2qm74 7283 26 ( ( -LRB- cord-015021-pol2qm74 7283 27 IGFBP-3 igfbp-3 NN cord-015021-pol2qm74 7283 28 ) ) -RRB- cord-015021-pol2qm74 7283 29 reflect reflect VB cord-015021-pol2qm74 7283 30 the the DT cord-015021-pol2qm74 7283 31 integrated integrated JJ cord-015021-pol2qm74 7283 32 GH GH NNP cord-015021-pol2qm74 7283 33 secretion secretion NN cord-015021-pol2qm74 7283 34 over over IN cord-015021-pol2qm74 7283 35 days day NNS cord-015021-pol2qm74 7283 36 . . . cord-015021-pol2qm74 7284 1 Since since IN cord-015021-pol2qm74 7284 2 we -PRON- PRP cord-015021-pol2qm74 7284 3 administer administer VBP cord-015021-pol2qm74 7284 4 clonidine clonidine NN cord-015021-pol2qm74 7284 5 to to IN cord-015021-pol2qm74 7284 6 patients patient NNS cord-015021-pol2qm74 7284 7 with with IN cord-015021-pol2qm74 7284 8 acute acute JJ cord-015021-pol2qm74 7284 9 alcohol alcohol NN cord-015021-pol2qm74 7284 10 abuse abuse NN cord-015021-pol2qm74 7284 11 we -PRON- PRP cord-015021-pol2qm74 7284 12 determined determine VBD cord-015021-pol2qm74 7284 13 plasma plasma NN cord-015021-pol2qm74 7284 14 levels level NNS cord-015021-pol2qm74 7284 15 of of IN cord-015021-pol2qm74 7284 16 IGF-1 IGF-1 NNP cord-015021-pol2qm74 7284 17 and and CC cord-015021-pol2qm74 7284 18 IGFBP-3 IGFBP-3 NNP cord-015021-pol2qm74 7284 19 . . . cord-015021-pol2qm74 7285 1 Materials material NNS cord-015021-pol2qm74 7285 2 and and CC cord-015021-pol2qm74 7285 3 methods method NNS cord-015021-pol2qm74 7285 4 : : : cord-015021-pol2qm74 7285 5 21 21 CD cord-015021-pol2qm74 7285 6 patients patient NNS cord-015021-pol2qm74 7285 7 sheduled shedule VBN cord-015021-pol2qm74 7285 8 for for IN cord-015021-pol2qm74 7285 9 esophagus esophagus NN cord-015021-pol2qm74 7285 10 resection resection NN cord-015021-pol2qm74 7285 11 were be VBD cord-015021-pol2qm74 7285 12 investigated investigate VBN cord-015021-pol2qm74 7285 13 once once IN cord-015021-pol2qm74 7285 14 they -PRON- PRP cord-015021-pol2qm74 7285 15 had have VBD cord-015021-pol2qm74 7285 16 given give VBN cord-015021-pol2qm74 7285 17 written write VBN cord-015021-pol2qm74 7285 18 informed informed JJ cord-015021-pol2qm74 7285 19 consent consent NN cord-015021-pol2qm74 7285 20 . . . cord-015021-pol2qm74 7286 1 8 8 CD cord-015021-pol2qm74 7286 2 patients patient NNS cord-015021-pol2qm74 7286 3 showed show VBD cord-015021-pol2qm74 7286 4 acute acute JJ cord-015021-pol2qm74 7286 5 alcohol alcohol NN cord-015021-pol2qm74 7286 6 abuse abuse NN cord-015021-pol2qm74 7286 7 and and CC cord-015021-pol2qm74 7286 8 were be VBD cord-015021-pol2qm74 7286 9 treated treat VBN cord-015021-pol2qm74 7286 10 with with IN cord-015021-pol2qm74 7286 11 clonidine clonidine NN cord-015021-pol2qm74 7286 12 postoperatively• postoperatively• NNP cord-015021-pol2qm74 7286 13 13 13 CD cord-015021-pol2qm74 7286 14 Patients patient NNS cord-015021-pol2qm74 7286 15 with with IN cord-015021-pol2qm74 7286 16 no no DT cord-015021-pol2qm74 7286 17 history history NN cord-015021-pol2qm74 7286 18 of of IN cord-015021-pol2qm74 7286 19 acute acute JJ cord-015021-pol2qm74 7286 20 alcohol alcohol NN cord-015021-pol2qm74 7286 21 abuse abuse NN cord-015021-pol2qm74 7286 22 served serve VBD cord-015021-pol2qm74 7286 23 as as IN cord-015021-pol2qm74 7286 24 controls control NNS cord-015021-pol2qm74 7286 25 . . . cord-015021-pol2qm74 7287 1 Besides besides IN cord-015021-pol2qm74 7287 2 liver liver NN cord-015021-pol2qm74 7287 3 enzymes enzyme NNS cord-015021-pol2qm74 7287 4 IGF-1 IGF-1 NNP cord-015021-pol2qm74 7287 5 and and CC cord-015021-pol2qm74 7287 6 IGFBP-3 IGFBP-3 NNP cord-015021-pol2qm74 7287 7 were be VBD cord-015021-pol2qm74 7287 8 determined determine VBN cord-015021-pol2qm74 7287 9 . . . cord-015021-pol2qm74 7288 1 Results result NNS cord-015021-pol2qm74 7288 2 : : : cord-015021-pol2qm74 7289 1 Both both DT cord-015021-pol2qm74 7289 2 groups group NNS cord-015021-pol2qm74 7289 3 had have VBD cord-015021-pol2qm74 7289 4 a a DT cord-015021-pol2qm74 7289 5 comparable comparable JJ cord-015021-pol2qm74 7289 6 hepatic hepatic JJ cord-015021-pol2qm74 7289 7 capacity capacity NN cord-015021-pol2qm74 7289 8 of of IN cord-015021-pol2qm74 7289 9 synthesis synthesis NN cord-015021-pol2qm74 7289 10 with with IN cord-015021-pol2qm74 7289 11 decreased decrease VBN cord-015021-pol2qm74 7289 12 cholinesterase cholinesterase NN cord-015021-pol2qm74 7289 13 levels level NNS cord-015021-pol2qm74 7289 14 as as IN cord-015021-pol2qm74 7289 15 to to TO cord-015021-pol2qm74 7289 16 be be VB cord-015021-pol2qm74 7289 17 expected expect VBN cord-015021-pol2qm74 7289 18 after after IN cord-015021-pol2qm74 7289 19 a a DT cord-015021-pol2qm74 7289 20 major major JJ cord-015021-pol2qm74 7289 21 operation operation NN cord-015021-pol2qm74 7289 22 . . . cord-015021-pol2qm74 7290 1 Regression regression NN cord-015021-pol2qm74 7290 2 analysis analysis NN cord-015021-pol2qm74 7290 3 of of IN cord-015021-pol2qm74 7290 4 IGF-1 IGF-1 NNP cord-015021-pol2qm74 7290 5 and and CC cord-015021-pol2qm74 7290 6 IGFBP-3 IGFBP-3 NNP cord-015021-pol2qm74 7290 7 levels level NNS cord-015021-pol2qm74 7290 8 showed show VBD cord-015021-pol2qm74 7290 9 no no DT cord-015021-pol2qm74 7290 10 differences difference NNS cord-015021-pol2qm74 7290 11 between between IN cord-015021-pol2qm74 7290 12 the the DT cord-015021-pol2qm74 7290 13 groups group NNS cord-015021-pol2qm74 7290 14 . . . cord-015021-pol2qm74 7291 1 Discussion discussion NN cord-015021-pol2qm74 7291 2 : : : cord-015021-pol2qm74 7292 1 IGF-1 IGF-1 NNP cord-015021-pol2qm74 7292 2 and and CC cord-015021-pol2qm74 7292 3 IGFBP-3 IGFBP-3 `` cord-015021-pol2qm74 7292 4 plasma plasma NN cord-015021-pol2qm74 7292 5 levels level NNS cord-015021-pol2qm74 7292 6 are be VBP cord-015021-pol2qm74 7292 7 not not RB cord-015021-pol2qm74 7292 8 increased increase VBN cord-015021-pol2qm74 7292 9 in in IN cord-015021-pol2qm74 7292 10 normotensive normotensive JJ cord-015021-pol2qm74 7292 11 patients patient NNS cord-015021-pol2qm74 7292 12 who who WP cord-015021-pol2qm74 7292 13 are be VBP cord-015021-pol2qm74 7292 14 treated treat VBN cord-015021-pol2qm74 7292 15 with with IN cord-015021-pol2qm74 7292 16 clonidine clonidine NN cord-015021-pol2qm74 7292 17 for for IN cord-015021-pol2qm74 7292 18 prevention prevention NN cord-015021-pol2qm74 7292 19 of of IN cord-015021-pol2qm74 7292 20 postoperative postoperative JJ cord-015021-pol2qm74 7292 21 alcohol alcohol NN cord-015021-pol2qm74 7292 22 withdrawl withdrawl NNP cord-015021-pol2qm74 7292 23 syndrom syndrom NNP cord-015021-pol2qm74 7292 24 . . . cord-015021-pol2qm74 7293 1 Further further JJ cord-015021-pol2qm74 7293 2 studies study NNS cord-015021-pol2qm74 7293 3 are be VBP cord-015021-pol2qm74 7293 4 required require VBN cord-015021-pol2qm74 7293 5 to to TO cord-015021-pol2qm74 7293 6 discriminate discriminate VB cord-015021-pol2qm74 7293 7 whether whether IN cord-015021-pol2qm74 7293 8 our -PRON- PRP$ cord-015021-pol2qm74 7293 9 results result NNS cord-015021-pol2qm74 7293 10 are be VBP cord-015021-pol2qm74 7293 11 due due JJ cord-015021-pol2qm74 7293 12 to to IN cord-015021-pol2qm74 7293 13 impaired impaired JJ cord-015021-pol2qm74 7293 14 postoperative postoperative JJ cord-015021-pol2qm74 7293 15 liver liver NN cord-015021-pol2qm74 7293 16 function function NN cord-015021-pol2qm74 7293 17 or or CC cord-015021-pol2qm74 7293 18 if if IN cord-015021-pol2qm74 7293 19 clonidine clonidine NN cord-015021-pol2qm74 7293 20 has have VBZ cord-015021-pol2qm74 7293 21 not not RB cord-015021-pol2qm74 7293 22 any any DT cord-015021-pol2qm74 7293 23 impact impact NN cord-015021-pol2qm74 7293 24 on on IN cord-015021-pol2qm74 7293 25 the the DT cord-015021-pol2qm74 7293 26 GH GH NNP cord-015021-pol2qm74 7293 27 - - HYPH cord-015021-pol2qm74 7293 28 IGF IGF NNP cord-015021-pol2qm74 7293 29 - - HYPH cord-015021-pol2qm74 7293 30 axis axis NN cord-015021-pol2qm74 7293 31 in in IN cord-015021-pol2qm74 7293 32 patients patient NNS cord-015021-pol2qm74 7293 33 with with IN cord-015021-pol2qm74 7293 34 alcohol alcohol NN cord-015021-pol2qm74 7293 35 abuse abuse NN cord-015021-pol2qm74 7293 36 . . . cord-015021-pol2qm74 7294 1 Recent recent JJ cord-015021-pol2qm74 7294 2 studies study NNS cord-015021-pol2qm74 7294 3 have have VBP cord-015021-pol2qm74 7294 4 revealed reveal VBN cord-015021-pol2qm74 7294 5 that that IN cord-015021-pol2qm74 7294 6 IGF IGF NNP cord-015021-pol2qm74 7294 7 - - : cord-015021-pol2qm74 7294 8 I -PRON- PRP cord-015021-pol2qm74 7294 9 has have VBZ cord-015021-pol2qm74 7294 10 several several JJ cord-015021-pol2qm74 7294 11 immanoregulatory immanoregulatory JJ cord-015021-pol2qm74 7294 12 roles role NNS cord-015021-pol2qm74 7294 13 . . . cord-015021-pol2qm74 7295 1 However however RB cord-015021-pol2qm74 7295 2 , , , cord-015021-pol2qm74 7295 3 little little JJ cord-015021-pol2qm74 7295 4 is be VBZ cord-015021-pol2qm74 7295 5 known know VBN cord-015021-pol2qm74 7295 6 about about IN cord-015021-pol2qm74 7295 7 its -PRON- PRP$ cord-015021-pol2qm74 7295 8 effects effect NNS cord-015021-pol2qm74 7295 9 on on IN cord-015021-pol2qm74 7295 10 septic septic JJ cord-015021-pol2qm74 7295 11 animals animal NNS cord-015021-pol2qm74 7295 12 . . . cord-015021-pol2qm74 7296 1 We -PRON- PRP cord-015021-pol2qm74 7296 2 tested test VBD cord-015021-pol2qm74 7296 3 whether whether IN cord-015021-pol2qm74 7296 4 IGF IGF NNP cord-015021-pol2qm74 7296 5 - - : cord-015021-pol2qm74 7296 6 I -PRON- PRP cord-015021-pol2qm74 7296 7 could could MD cord-015021-pol2qm74 7296 8 increase increase VB cord-015021-pol2qm74 7296 9 the the DT cord-015021-pol2qm74 7296 10 survival survival NN cord-015021-pol2qm74 7296 11 O o NN cord-015021-pol2qm74 7296 12 f f NN cord-015021-pol2qm74 7296 13 mice mouse NNS cord-015021-pol2qm74 7296 14 challenged challenge VBD cord-015021-pol2qm74 7296 15 intraperitoneally intraperitoneally RB cord-015021-pol2qm74 7296 16 ( ( -LRB- cord-015021-pol2qm74 7296 17 i.p i.p NNP cord-015021-pol2qm74 7296 18 . . NNP cord-015021-pol2qm74 7296 19 ) ) -RRB- cord-015021-pol2qm74 7296 20 with with IN cord-015021-pol2qm74 7296 21 E. E. NNP cord-015021-pol2qm74 7296 22 coli coli NNS cord-015021-pol2qm74 7296 23 . . . cord-015021-pol2qm74 7297 1 M~ M~ NNP cord-015021-pol2qm74 7298 1 THQD$ THQD$ NNP cord-015021-pol2qm74 7298 2 BALB BALB NNP cord-015021-pol2qm74 7298 3 / / SYM cord-015021-pol2qm74 7298 4 c c NN cord-015021-pol2qm74 7298 5 mice mouse NNS cord-015021-pol2qm74 7298 6 received receive VBD cord-015021-pol2qm74 7298 7 either either CC cord-015021-pol2qm74 7298 8 high high JJ cord-015021-pol2qm74 7298 9 dose dose NN cord-015021-pol2qm74 7298 10 IGF IGF NNP cord-015021-pol2qm74 7298 11 - - HYPH cord-015021-pol2qm74 7298 12 I I NNP cord-015021-pol2qm74 7298 13 ( ( -LRB- cord-015021-pol2qm74 7298 14 n=10 n=10 NNP cord-015021-pol2qm74 7298 15 , , , cord-015021-pol2qm74 7298 16 24mg 24mg NNP cord-015021-pol2qm74 7298 17 / / SYM cord-015021-pol2qm74 7298 18 kg kg NN cord-015021-pol2qm74 7298 19 / / SYM cord-015021-pol2qm74 7298 20 day day NN cord-015021-pol2qm74 7298 21 ) ) -RRB- cord-015021-pol2qm74 7298 22 , , , cord-015021-pol2qm74 7298 23 low low JJ cord-015021-pol2qm74 7298 24 dose dose NN cord-015021-pol2qm74 7298 25 IGF IGF NNP cord-015021-pol2qm74 7298 26 - - HYPH cord-015021-pol2qm74 7298 27 I I NNP cord-015021-pol2qm74 7298 28 ( ( -LRB- cord-015021-pol2qm74 7298 29 n=10 n=10 NNP cord-015021-pol2qm74 7298 30 , , , cord-015021-pol2qm74 7298 31 2.4mg 2.4mg CD cord-015021-pol2qm74 7298 32 / / SYM cord-015021-pol2qm74 7298 33 kg kg NN cord-015021-pol2qm74 7298 34 / / SYM cord-015021-pol2qm74 7298 35 day day NN cord-015021-pol2qm74 7298 36 ) ) -RRB- cord-015021-pol2qm74 7298 37 or or CC cord-015021-pol2qm74 7298 38 saline saline NN cord-015021-pol2qm74 7298 39 ( ( -LRB- cord-015021-pol2qm74 7298 40 11=10 11=10 CD cord-015021-pol2qm74 7298 41 ) ) -RRB- cord-015021-pol2qm74 7299 1 every every DT cord-015021-pol2qm74 7299 2 eight eight CD cord-015021-pol2qm74 7299 3 hours hour NNS cord-015021-pol2qm74 7299 4 subcutaneously subcutaneously RB cord-015021-pol2qm74 7299 5 for for IN cord-015021-pol2qm74 7299 6 six six CD cord-015021-pol2qm74 7299 7 days day NNS cord-015021-pol2qm74 7299 8 . . . cord-015021-pol2qm74 7300 1 Animals animal NNS cord-015021-pol2qm74 7300 2 were be VBD cord-015021-pol2qm74 7300 3 then then RB cord-015021-pol2qm74 7300 4 challenged challenge VBN cord-015021-pol2qm74 7300 5 i.p i.p NNP cord-015021-pol2qm74 7300 6 . . NNP cord-015021-pol2qm74 7300 7 with with IN cord-015021-pol2qm74 7300 8 lx108 lx108 NNP cord-015021-pol2qm74 7300 9 E. E. NNP cord-015021-pol2qm74 7300 10 coli coli NNS cord-015021-pol2qm74 7300 11 . . . cord-015021-pol2qm74 7301 1 Survival survival NN cord-015021-pol2qm74 7301 2 was be VBD cord-015021-pol2qm74 7301 3 observed observe VBN cord-015021-pol2qm74 7301 4 every every DT cord-015021-pol2qm74 7301 5 two two CD cord-015021-pol2qm74 7301 6 hours hour NNS cord-015021-pol2qm74 7301 7 . . . cord-015021-pol2qm74 7302 1 In in IN cord-015021-pol2qm74 7302 2 the the DT cord-015021-pol2qm74 7302 3 other other JJ cord-015021-pol2qm74 7302 4 experiment experiment NN cord-015021-pol2qm74 7302 5 , , , cord-015021-pol2qm74 7302 6 mice mouse NNS cord-015021-pol2qm74 7302 7 that that WDT cord-015021-pol2qm74 7302 8 received receive VBD cord-015021-pol2qm74 7302 9 high high JJ cord-015021-pol2qm74 7302 10 dose dose NN cord-015021-pol2qm74 7302 11 IGF IGF NNP cord-015021-pol2qm74 7302 12 - - HYPH cord-015021-pol2qm74 7302 13 I i NN cord-015021-pol2qm74 7302 14 or or CC cord-015021-pol2qm74 7302 15 saline saline NN cord-015021-pol2qm74 7302 16 were be VBD cord-015021-pol2qm74 7302 17 sacrificed sacrifice VBN cord-015021-pol2qm74 7302 18 four four CD cord-015021-pol2qm74 7302 19 hours hour NNS cord-015021-pol2qm74 7302 20 after after IN cord-015021-pol2qm74 7302 21 bacterial bacterial JJ cord-015021-pol2qm74 7302 22 challenge challenge NN cord-015021-pol2qm74 7302 23 . . . cord-015021-pol2qm74 7303 1 Peritoneal peritoneal JJ cord-015021-pol2qm74 7303 2 cavity cavity NN cord-015021-pol2qm74 7303 3 was be VBD cord-015021-pol2qm74 7303 4 lavaged lavage VBN cord-015021-pol2qm74 7303 5 with with IN cord-015021-pol2qm74 7303 6 3ml 3ml NN cord-015021-pol2qm74 7303 7 saline saline NN cord-015021-pol2qm74 7303 8 and and CC cord-015021-pol2qm74 7303 9 the the DT cord-015021-pol2qm74 7303 10 peritoneal peritoneal JJ cord-015021-pol2qm74 7303 11 exudative exudative NNP cord-015021-pol2qm74 7303 12 ceils ceils NNP cord-015021-pol2qm74 7303 13 ( ( -LRB- cord-015021-pol2qm74 7303 14 PEC PEC NNP cord-015021-pol2qm74 7303 15 ) ) -RRB- cord-015021-pol2qm74 7303 16 were be VBD cord-015021-pol2qm74 7303 17 harvested harvest VBN cord-015021-pol2qm74 7303 18 and and CC cord-015021-pol2qm74 7303 19 counted count VBN cord-015021-pol2qm74 7303 20 . . . cord-015021-pol2qm74 7304 1 Colony colony NN cord-015021-pol2qm74 7304 2 forming form VBG cord-015021-pol2qm74 7304 3 units unit NNS cord-015021-pol2qm74 7304 4 ( ( -LRB- cord-015021-pol2qm74 7304 5 CFU CFU NNP cord-015021-pol2qm74 7304 6 ) ) -RRB- cord-015021-pol2qm74 7304 7 of of IN cord-015021-pol2qm74 7304 8 bacteria bacteria NNS cord-015021-pol2qm74 7304 9 in in IN cord-015021-pol2qm74 7304 10 the the DT cord-015021-pol2qm74 7304 11 peritoneal peritoneal NN cord-015021-pol2qm74 7304 12 lavaged lavaged NN cord-015021-pol2qm74 7304 13 fluid fluid NN cord-015021-pol2qm74 7304 14 ( ( -LRB- cord-015021-pol2qm74 7304 15 PLF PLF NNP cord-015021-pol2qm74 7304 16 ) ) -RRB- cord-015021-pol2qm74 7304 17 , , , cord-015021-pol2qm74 7304 18 liver liver NN cord-015021-pol2qm74 7304 19 , , , cord-015021-pol2qm74 7304 20 lung lung NN cord-015021-pol2qm74 7304 21 and and CC cord-015021-pol2qm74 7304 22 blood blood NN cord-015021-pol2qm74 7304 23 were be VBD cord-015021-pol2qm74 7304 24 determined determine VBN cord-015021-pol2qm74 7304 25 . . . cord-015021-pol2qm74 7305 1 In in IN cord-015021-pol2qm74 7305 2 addition addition NN cord-015021-pol2qm74 7305 3 , , , cord-015021-pol2qm74 7305 4 PEC PEC NNP cord-015021-pol2qm74 7305 5 were be VBD cord-015021-pol2qm74 7305 6 cultured culture VBN cord-015021-pol2qm74 7305 7 / / SYM cord-015021-pol2qm74 7305 8 n n CC cord-015021-pol2qm74 7305 9 vitro vitro FW cord-015021-pol2qm74 7305 10 for for IN cord-015021-pol2qm74 7305 11 24 24 CD cord-015021-pol2qm74 7305 12 hours hour NNS cord-015021-pol2qm74 7305 13 with with IN cord-015021-pol2qm74 7305 14 lipopolysaccharide lipopolysaccharide NN cord-015021-pol2qm74 7305 15 ( ( -LRB- cord-015021-pol2qm74 7305 16 10).tg 10).tg CD cord-015021-pol2qm74 7305 17 / / SYM cord-015021-pol2qm74 7305 18 ml ml NN cord-015021-pol2qm74 7305 19 ) ) -RRB- cord-015021-pol2qm74 7305 20 . . . cord-015021-pol2qm74 7306 1 Tumor tumor NN cord-015021-pol2qm74 7306 2 necrosis necrosis NN cord-015021-pol2qm74 7306 3 factor factor NN cord-015021-pol2qm74 7306 4 ( ( -LRB- cord-015021-pol2qm74 7306 5 TNF TNF NNP cord-015021-pol2qm74 7306 6 ) ) -RRB- cord-015021-pol2qm74 7306 7 in in IN cord-015021-pol2qm74 7306 8 the the DT cord-015021-pol2qm74 7306 9 supernatants supernatant NNS cord-015021-pol2qm74 7306 10 of of IN cord-015021-pol2qm74 7306 11 PEC pec NN cord-015021-pol2qm74 7306 12 culture culture NN cord-015021-pol2qm74 7306 13 , , , cord-015021-pol2qm74 7306 14 PLF PLF NNP cord-015021-pol2qm74 7306 15 and and CC cord-015021-pol2qm74 7306 16 serum serum NN cord-015021-pol2qm74 7306 17 were be VBD cord-015021-pol2qm74 7306 18 measured measure VBN cord-015021-pol2qm74 7306 19 by by IN cord-015021-pol2qm74 7306 20 L929 l929 CD cord-015021-pol2qm74 7306 21 bioassay bioassay NN cord-015021-pol2qm74 7306 22 . . . cord-015021-pol2qm74 7307 1 RESULTS result NNS cord-015021-pol2qm74 7307 2 IGF IGF NNP cord-015021-pol2qm74 7308 1 -I -i WDT cord-015021-pol2qm74 7308 2 improved improve VBD cord-015021-pol2qm74 7308 3 the the DT cord-015021-pol2qm74 7308 4 survival survival NN cord-015021-pol2qm74 7308 5 rate rate NN cord-015021-pol2qm74 7308 6 at at IN cord-015021-pol2qm74 7308 7 a a DT cord-015021-pol2qm74 7308 8 dose dose NN cord-015021-pol2qm74 7308 9 of of IN cord-015021-pol2qm74 7308 10 24mg 24mg NN cord-015021-pol2qm74 7308 11 / / SYM cord-015021-pol2qm74 7308 12 kg kg NN cord-015021-pol2qm74 7308 13 / / SYM cord-015021-pol2qm74 7308 14 day day NN cord-015021-pol2qm74 7308 15 . . . cord-015021-pol2qm74 7309 1 Severe severe JJ cord-015021-pol2qm74 7309 2 chronic chronic JJ cord-015021-pol2qm74 7309 3 neutropenia neutropenia NN cord-015021-pol2qm74 7309 4 ( ( -LRB- cord-015021-pol2qm74 7309 5 SCN SCN NNP cord-015021-pol2qm74 7309 6 ) ) -RRB- cord-015021-pol2qm74 7309 7 is be VBZ cord-015021-pol2qm74 7309 8 a a DT cord-015021-pol2qm74 7309 9 disorder disorder NN cord-015021-pol2qm74 7309 10 characterized characterize VBN cord-015021-pol2qm74 7309 11 by by IN cord-015021-pol2qm74 7309 12 severe severe JJ cord-015021-pol2qm74 7309 13 neutropenia neutropenia NN cord-015021-pol2qm74 7309 14 secondary secondary JJ cord-015021-pol2qm74 7309 15 to to IN cord-015021-pol2qm74 7309 16 either either CC cord-015021-pol2qm74 7309 17 a a DT cord-015021-pol2qm74 7309 18 maturational maturational JJ cord-015021-pol2qm74 7309 19 arrest arrest NN cord-015021-pol2qm74 7309 20 of of IN cord-015021-pol2qm74 7309 21 myelopoiesis myelopoiesis NN cord-015021-pol2qm74 7309 22 at at IN cord-015021-pol2qm74 7309 23 the the DT cord-015021-pol2qm74 7309 24 level level NN cord-015021-pol2qm74 7309 25 of of IN cord-015021-pol2qm74 7309 26 promyelocytes promyelocyte NNS cord-015021-pol2qm74 7309 27 ( ( -LRB- cord-015021-pol2qm74 7309 28 Kostmann Kostmann NNP cord-015021-pol2qm74 7309 29 - - HYPH cord-015021-pol2qm74 7309 30 Syndrome Syndrome NNP cord-015021-pol2qm74 7309 31 ; ; : cord-015021-pol2qm74 7309 32 SCN SCN NNP cord-015021-pol2qm74 7309 33 ) ) -RRB- cord-015021-pol2qm74 7309 34 or or CC cord-015021-pol2qm74 7309 35 regular regular JJ cord-015021-pol2qm74 7309 36 cyclic cyclic JJ cord-015021-pol2qm74 7309 37 fluctuations fluctuation NNS cord-015021-pol2qm74 7309 38 in in IN cord-015021-pol2qm74 7309 39 the the DT cord-015021-pol2qm74 7309 40 number number NN cord-015021-pol2qm74 7309 41 of of IN cord-015021-pol2qm74 7309 42 blood blood NN cord-015021-pol2qm74 7309 43 neutrophils neutrophil NNS cord-015021-pol2qm74 7309 44 with with IN cord-015021-pol2qm74 7309 45 a a DT cord-015021-pol2qm74 7309 46 median median JJ cord-015021-pol2qm74 7309 47 absolute absolute JJ cord-015021-pol2qm74 7309 48 neutrophil neutrophil NN cord-015021-pol2qm74 7309 49 count count NN cord-015021-pol2qm74 7309 50 ( ( -LRB- cord-015021-pol2qm74 7309 51 ANC ANC NNP cord-015021-pol2qm74 7309 52 ) ) -RRB- cord-015021-pol2qm74 7309 53 of of IN cord-015021-pol2qm74 7309 54 less less JJR cord-015021-pol2qm74 7309 55 than than IN cord-015021-pol2qm74 7309 56 500/~tl 500/~tl CD cord-015021-pol2qm74 7309 57 ( ( -LRB- cord-015021-pol2qm74 7309 58 cyclic cyclic JJ cord-015021-pol2qm74 7309 59 neutropenia neutropenia NN cord-015021-pol2qm74 7309 60 ) ) -RRB- cord-015021-pol2qm74 7309 61 . . . cord-015021-pol2qm74 7310 1 Patients patient NNS cord-015021-pol2qm74 7310 2 suffering suffer VBG cord-015021-pol2qm74 7310 3 from from IN cord-015021-pol2qm74 7310 4 SCN SCN NNP cord-015021-pol2qm74 7310 5 have have VBP cord-015021-pol2qm74 7310 6 an an DT cord-015021-pol2qm74 7310 7 impaired impaired JJ cord-015021-pol2qm74 7310 8 acute acute JJ cord-015021-pol2qm74 7310 9 inflammatory inflammatory JJ cord-015021-pol2qm74 7310 10 response response NN cord-015021-pol2qm74 7310 11 to to IN cord-015021-pol2qm74 7310 12 injury injury NN cord-015021-pol2qm74 7310 13 and and CC cord-015021-pol2qm74 7310 14 an an DT cord-015021-pol2qm74 7310 15 increased increase VBN cord-015021-pol2qm74 7310 16 susceptibility susceptibility NN cord-015021-pol2qm74 7310 17 to to IN cord-015021-pol2qm74 7310 18 infections infection NNS cord-015021-pol2qm74 7310 19 , , , cord-015021-pol2qm74 7310 20 i.e. i.e. FW cord-015021-pol2qm74 7310 21 bacterial bacterial JJ cord-015021-pol2qm74 7310 22 or or CC cord-015021-pol2qm74 7310 23 fungal fungal JJ cord-015021-pol2qm74 7310 24 infections infection NNS cord-015021-pol2qm74 7310 25 , , , cord-015021-pol2qm74 7310 26 resulting result VBG cord-015021-pol2qm74 7310 27 in in IN cord-015021-pol2qm74 7310 28 chronic chronic JJ cord-015021-pol2qm74 7310 29 oral oral JJ cord-015021-pol2qm74 7310 30 inflammation inflammation NN cord-015021-pol2qm74 7310 31 , , , cord-015021-pol2qm74 7310 32 severe severe JJ cord-015021-pol2qm74 7310 33 pneumonia pneumonia NN cord-015021-pol2qm74 7310 34 , , , cord-015021-pol2qm74 7310 35 abscess abscess NN cord-015021-pol2qm74 7310 36 formation formation NN cord-015021-pol2qm74 7310 37 and and CC cord-015021-pol2qm74 7310 38 bacteraemia bacteraemia NN cord-015021-pol2qm74 7310 39 . . . cord-015021-pol2qm74 7311 1 We -PRON- PRP cord-015021-pol2qm74 7311 2 have have VBP cord-015021-pol2qm74 7311 3 treated treat VBN cord-015021-pol2qm74 7311 4 36 36 CD cord-015021-pol2qm74 7311 5 patients patient NNS cord-015021-pol2qm74 7311 6 ( ( -LRB- cord-015021-pol2qm74 7311 7 32 32 CD cord-015021-pol2qm74 7311 8 SCN SCN NNP cord-015021-pol2qm74 7311 9 , , , cord-015021-pol2qm74 7311 10 4 4 CD cord-015021-pol2qm74 7311 11 cyclic cyclic JJ cord-015021-pol2qm74 7311 12 neutropenia neutropenia NN cord-015021-pol2qm74 7311 13 ) ) -RRB- cord-015021-pol2qm74 7311 14 with with IN cord-015021-pol2qm74 7311 15 r r NNP cord-015021-pol2qm74 7311 16 - - HYPH cord-015021-pol2qm74 7311 17 metHuG metHuG NNP cord-015021-pol2qm74 7311 18 - - HYPH cord-015021-pol2qm74 7311 19 CSF CSF NNP cord-015021-pol2qm74 7311 20 ( ( -LRB- cord-015021-pol2qm74 7311 21 filgrastim filgrastim NNP cord-015021-pol2qm74 7311 22 ) ) -RRB- cord-015021-pol2qm74 7311 23 . . . cord-015021-pol2qm74 7312 1 Thirty thirty CD cord-015021-pol2qm74 7312 2 of of IN cord-015021-pol2qm74 7312 3 32 32 CD cord-015021-pol2qm74 7312 4 patients patient NNS cord-015021-pol2qm74 7312 5 with with IN cord-015021-pol2qm74 7312 6 SCN SCN NNP cord-015021-pol2qm74 7312 7 and and CC cord-015021-pol2qm74 7312 8 all all DT cord-015021-pol2qm74 7312 9 4 4 CD cord-015021-pol2qm74 7312 10 cyclic cyclic JJ cord-015021-pol2qm74 7312 11 neutropenia neutropenia NN cord-015021-pol2qm74 7312 12 patients patient NNS cord-015021-pol2qm74 7312 13 responded respond VBD cord-015021-pol2qm74 7312 14 to to IN cord-015021-pol2qm74 7312 15 this this DT cord-015021-pol2qm74 7312 16 treatment treatment NN cord-015021-pol2qm74 7312 17 with with IN cord-015021-pol2qm74 7312 18 an an DT cord-015021-pol2qm74 7312 19 increase increase NN cord-015021-pol2qm74 7312 20 of of IN cord-015021-pol2qm74 7312 21 the the DT cord-015021-pol2qm74 7312 22 median median JJ cord-015021-pol2qm74 7312 23 ANC ANC NNP cord-015021-pol2qm74 7312 24 to to IN cord-015021-pol2qm74 7312 25 greater great JJR cord-015021-pol2qm74 7312 26 than than IN cord-015021-pol2qm74 7312 27 1000/~tl 1000/~tl CD cord-015021-pol2qm74 7312 28 . . . cord-015021-pol2qm74 7313 1 The the DT cord-015021-pol2qm74 7313 2 dose dose NN cord-015021-pol2qm74 7313 3 of of IN cord-015021-pol2qm74 7313 4 r r JJ cord-015021-pol2qm74 7313 5 - - HYPH cord-015021-pol2qm74 7313 6 metHuG metHuG NNP cord-015021-pol2qm74 7313 7 - - HYPH cord-015021-pol2qm74 7313 8 CSF CSF NNP cord-015021-pol2qm74 7313 9 needed need VBD cord-015021-pol2qm74 7313 10 to to TO cord-015021-pol2qm74 7313 11 achieve achieve VB cord-015021-pol2qm74 7313 12 and and CC cord-015021-pol2qm74 7313 13 maintain maintain VB cord-015021-pol2qm74 7313 14 the the DT cord-015021-pol2qm74 7313 15 response response NN cord-015021-pol2qm74 7313 16 varied vary VBN cord-015021-pol2qm74 7313 17 between between IN cord-015021-pol2qm74 7313 18 0.8 0.8 CD cord-015021-pol2qm74 7313 19 and and CC cord-015021-pol2qm74 7313 20 120 120 CD cord-015021-pol2qm74 7314 1 ~tg ~tg NNP cord-015021-pol2qm74 7314 2 / / SYM cord-015021-pol2qm74 7314 3 kg kg NN cord-015021-pol2qm74 7314 4 / / SYM cord-015021-pol2qm74 7314 5 d d NN cord-015021-pol2qm74 7314 6 . . . cord-015021-pol2qm74 7315 1 Long long JJ cord-015021-pol2qm74 7315 2 - - HYPH cord-015021-pol2qm74 7315 3 term term NN cord-015021-pol2qm74 7315 4 treatment treatment NN cord-015021-pol2qm74 7315 5 did do VBD cord-015021-pol2qm74 7315 6 not not RB cord-015021-pol2qm74 7315 7 exhaust exhaust VB cord-015021-pol2qm74 7315 8 myelopoiesis myelopoiesis NN cord-015021-pol2qm74 7315 9 : : : cord-015021-pol2qm74 7315 10 the the DT cord-015021-pol2qm74 7315 11 ANC ANC NNP cord-015021-pol2qm74 7315 12 remained remain VBD cord-015021-pol2qm74 7315 13 stable stable JJ cord-015021-pol2qm74 7315 14 after after IN cord-015021-pol2qm74 7315 15 up up IN cord-015021-pol2qm74 7315 16 to to TO cord-015021-pol2qm74 7315 17 6 6 CD cord-015021-pol2qm74 7315 18 years year NNS cord-015021-pol2qm74 7315 19 of of IN cord-015021-pol2qm74 7315 20 treatment treatment NN cord-015021-pol2qm74 7315 21 and and CC cord-015021-pol2qm74 7315 22 antibodies antibody NNS cord-015021-pol2qm74 7315 23 to to IN cord-015021-pol2qm74 7316 1 r r LS cord-015021-pol2qm74 7316 2 - - : cord-015021-pol2qm74 7316 3 metHuG metHuG NNP cord-015021-pol2qm74 7316 4 - - HYPH cord-015021-pol2qm74 7316 5 CSF CSF NNP cord-015021-pol2qm74 7316 6 were be VBD cord-015021-pol2qm74 7316 7 not not RB cord-015021-pol2qm74 7316 8 detected detect VBN cord-015021-pol2qm74 7316 9 . . . cord-015021-pol2qm74 7317 1 The the DT cord-015021-pol2qm74 7317 2 increase increase NN cord-015021-pol2qm74 7317 3 of of IN cord-015021-pol2qm74 7317 4 ANC ANC NNP cord-015021-pol2qm74 7317 5 was be VBD cord-015021-pol2qm74 7317 6 associated associate VBN cord-015021-pol2qm74 7317 7 with with IN cord-015021-pol2qm74 7317 8 dramatic dramatic JJ cord-015021-pol2qm74 7317 9 clinical clinical JJ cord-015021-pol2qm74 7317 10 responses response NNS cord-015021-pol2qm74 7317 11 : : : cord-015021-pol2qm74 7317 12 significant significant JJ cord-015021-pol2qm74 7317 13 reduction reduction NN cord-015021-pol2qm74 7317 14 of of IN cord-015021-pol2qm74 7317 15 severe severe JJ cord-015021-pol2qm74 7317 16 bacterial bacterial JJ cord-015021-pol2qm74 7317 17 infections infection NNS cord-015021-pol2qm74 7317 18 , , , cord-015021-pol2qm74 7317 19 reduction reduction NN cord-015021-pol2qm74 7317 20 of of IN cord-015021-pol2qm74 7317 21 intravenous intravenous JJ cord-015021-pol2qm74 7317 22 antibiotic antibiotic JJ cord-015021-pol2qm74 7317 23 treatment treatment NN cord-015021-pol2qm74 7317 24 , , , cord-015021-pol2qm74 7317 25 and and CC cord-015021-pol2qm74 7317 26 reduction reduction NN cord-015021-pol2qm74 7317 27 of of IN cord-015021-pol2qm74 7317 28 hospitalizations hospitalization NNS cord-015021-pol2qm74 7317 29 . . . cord-015021-pol2qm74 7318 1 No no DT cord-015021-pol2qm74 7318 2 severe severe JJ cord-015021-pol2qm74 7318 3 bacterial bacterial JJ cord-015021-pol2qm74 7318 4 infections infection NNS cord-015021-pol2qm74 7318 5 occurred occur VBD cord-015021-pol2qm74 7318 6 in in IN cord-015021-pol2qm74 7318 7 any any DT cord-015021-pol2qm74 7318 8 of of IN cord-015021-pol2qm74 7318 9 the the DT cord-015021-pol2qm74 7318 10 r r NN cord-015021-pol2qm74 7318 11 - - HYPH cord-015021-pol2qm74 7318 12 rnetHuG rnetHuG NNP cord-015021-pol2qm74 7318 13 - - HYPH cord-015021-pol2qm74 7318 14 CSF csf NN cord-015021-pol2qm74 7318 15 responders responder NNS cord-015021-pol2qm74 7318 16 during during IN cord-015021-pol2qm74 7318 17 longterm longterm JJ cord-015021-pol2qm74 7318 18 treatment treatment NN cord-015021-pol2qm74 7318 19 . . . cord-015021-pol2qm74 7319 1 Severe severe JJ cord-015021-pol2qm74 7319 2 adverse adverse JJ cord-015021-pol2qm74 7319 3 events event NNS cord-015021-pol2qm74 7319 4 , , , cord-015021-pol2qm74 7319 5 most most RBS cord-015021-pol2qm74 7319 6 likely likely JJ cord-015021-pol2qm74 7319 7 due due IN cord-015021-pol2qm74 7319 8 to to IN cord-015021-pol2qm74 7319 9 the the DT cord-015021-pol2qm74 7319 10 underlying underlie VBG cord-015021-pol2qm74 7319 11 disease disease NN cord-015021-pol2qm74 7319 12 , , , cord-015021-pol2qm74 7319 13 included include VBD cord-015021-pol2qm74 7319 14 the the DT cord-015021-pol2qm74 7319 15 development development NN cord-015021-pol2qm74 7319 16 of of IN cord-015021-pol2qm74 7319 17 MDS MDS NNP cord-015021-pol2qm74 7319 18 / / SYM cord-015021-pol2qm74 7319 19 Leukemia Leukemia NNP cord-015021-pol2qm74 7319 20 in in IN cord-015021-pol2qm74 7319 21 two two CD cord-015021-pol2qm74 7319 22 patients patient NNS cord-015021-pol2qm74 7319 23 , , , cord-015021-pol2qm74 7319 24 and and CC cord-015021-pol2qm74 7319 25 osteopenia osteopenia NN cord-015021-pol2qm74 7319 26 / / SYM cord-015021-pol2qm74 7319 27 osteoporosis osteoporosis NN cord-015021-pol2qm74 7319 28 in in IN cord-015021-pol2qm74 7319 29 12 12 CD cord-015021-pol2qm74 7319 30 patients patient NNS cord-015021-pol2qm74 7319 31 . . . cord-015021-pol2qm74 7320 1 These these DT cord-015021-pol2qm74 7320 2 results result NNS cord-015021-pol2qm74 7320 3 demonstrate demonstrate VBP cord-015021-pol2qm74 7320 4 the the DT cord-015021-pol2qm74 7320 5 beneficial beneficial JJ cord-015021-pol2qm74 7320 6 effects effect NNS cord-015021-pol2qm74 7320 7 of of IN cord-015021-pol2qm74 7320 8 r r NN cord-015021-pol2qm74 7320 9 - - HYPH cord-015021-pol2qm74 7320 10 metHuG metHuG NNP cord-015021-pol2qm74 7320 11 - - HYPH cord-015021-pol2qm74 7320 12 CSF csf NN cord-015021-pol2qm74 7320 13 treatment treatment NN cord-015021-pol2qm74 7320 14 in in IN cord-015021-pol2qm74 7320 15 severe severe JJ cord-015021-pol2qm74 7320 16 chronic chronic JJ cord-015021-pol2qm74 7320 17 neutropenia neutropenia NN cord-015021-pol2qm74 7320 18 patients patient NNS cord-015021-pol2qm74 7320 19 . . . cord-015021-pol2qm74 7321 1 The the DT cord-015021-pol2qm74 7321 2 newborn newborn NN cord-015021-pol2qm74 7321 3 is be VBZ cord-015021-pol2qm74 7321 4 predisposed predisposed JJ cord-015021-pol2qm74 7321 5 to to IN cord-015021-pol2qm74 7321 6 mortality mortality NN cord-015021-pol2qm74 7321 7 during during IN cord-015021-pol2qm74 7321 8 infections infection NNS cord-015021-pol2qm74 7321 9 due due JJ cord-015021-pol2qm74 7321 10 in in IN cord-015021-pol2qm74 7321 11 large large JJ cord-015021-pol2qm74 7321 12 part part NN cord-015021-pol2qm74 7321 13 to to IN cord-015021-pol2qm74 7321 14 developmentally developmentally RB cord-015021-pol2qm74 7321 15 immature immature JJ cord-015021-pol2qm74 7321 16 host host NN cord-015021-pol2qm74 7321 17 defenses defense NNS cord-015021-pol2qm74 7321 18 . . . cord-015021-pol2qm74 7322 1 Recently recently RB cord-015021-pol2qm74 7322 2 cytokines cytokine NNS cord-015021-pol2qm74 7322 3 have have VBP cord-015021-pol2qm74 7322 4 been be VBN cord-015021-pol2qm74 7322 5 identified identify VBN cord-015021-pol2qm74 7322 6 that that WDT cord-015021-pol2qm74 7322 7 regulate regulate VBP cord-015021-pol2qm74 7322 8 the the DT cord-015021-pol2qm74 7322 9 development development NN cord-015021-pol2qm74 7322 10 of of IN cord-015021-pol2qm74 7322 11 these these DT cord-015021-pol2qm74 7322 12 defenses defense NNS cord-015021-pol2qm74 7322 13 . . . cord-015021-pol2qm74 7323 1 One one CD cord-015021-pol2qm74 7323 2 such such JJ cord-015021-pol2qm74 7323 3 cytokine cytokine NN cord-015021-pol2qm74 7323 4 is be VBZ cord-015021-pol2qm74 7323 5 specific specific JJ cord-015021-pol2qm74 7323 6 for for IN cord-015021-pol2qm74 7323 7 neutrophils neutrophil NNS cord-015021-pol2qm74 7323 8 and and CC cord-015021-pol2qm74 7323 9 is be VBZ cord-015021-pol2qm74 7323 10 termed term VBN cord-015021-pol2qm74 7323 11 granulocyte granulocyte NN cord-015021-pol2qm74 7323 12 colony colony NN cord-015021-pol2qm74 7323 13 stimulating stimulate VBG cord-015021-pol2qm74 7323 14 factor factor NN cord-015021-pol2qm74 7323 15 ( ( -LRB- cord-015021-pol2qm74 7323 16 G G NNP cord-015021-pol2qm74 7323 17 - - HYPH cord-015021-pol2qm74 7323 18 CSF CSF NNP cord-015021-pol2qm74 7323 19 ) ) -RRB- cord-015021-pol2qm74 7323 20 . . . cord-015021-pol2qm74 7324 1 In in IN cord-015021-pol2qm74 7324 2 the the DT cord-015021-pol2qm74 7324 3 studies study NNS cord-015021-pol2qm74 7324 4 to to TO cord-015021-pol2qm74 7324 5 be be VB cord-015021-pol2qm74 7324 6 discussed discuss VBN cord-015021-pol2qm74 7324 7 , , , cord-015021-pol2qm74 7324 8 we -PRON- PRP cord-015021-pol2qm74 7324 9 have have VBP cord-015021-pol2qm74 7324 10 attempted attempt VBN cord-015021-pol2qm74 7324 11 to to TO cord-015021-pol2qm74 7324 12 impact impact VB cord-015021-pol2qm74 7324 13 hematopoiesis hematopoiesis NN cord-015021-pol2qm74 7324 14 in in IN cord-015021-pol2qm74 7324 15 the the DT cord-015021-pol2qm74 7324 16 fetus fetus NN cord-015021-pol2qm74 7324 17 using use VBG cord-015021-pol2qm74 7324 18 exogenous exogenous JJ cord-015021-pol2qm74 7324 19 rhG rhG NNP cord-015021-pol2qm74 7324 20 - - HYPH cord-015021-pol2qm74 7324 21 CSF csf NN cord-015021-pol2qm74 7324 22 delivered deliver VBD cord-015021-pol2qm74 7324 23 through through IN cord-015021-pol2qm74 7324 24 the the DT cord-015021-pol2qm74 7324 25 pregnant pregnant JJ cord-015021-pol2qm74 7324 26 dam dam NN cord-015021-pol2qm74 7324 27 . . . cord-015021-pol2qm74 7325 1 Our -PRON- PRP$ cord-015021-pol2qm74 7325 2 rationale rationale NN cord-015021-pol2qm74 7325 3 was be VBD cord-015021-pol2qm74 7325 4 that that IN cord-015021-pol2qm74 7325 5 an an DT cord-015021-pol2qm74 7325 6 enhanced enhanced JJ cord-015021-pol2qm74 7325 7 myeloid myeloid NN cord-015021-pol2qm74 7325 8 system system NN cord-015021-pol2qm74 7325 9 may may MD cord-015021-pol2qm74 7325 10 result result VB cord-015021-pol2qm74 7325 11 from from IN cord-015021-pol2qm74 7325 12 such such JJ cord-015021-pol2qm74 7325 13 in in IN cord-015021-pol2qm74 7325 14 utero utero NN cord-015021-pol2qm74 7325 15 treatment treatment NN cord-015021-pol2qm74 7325 16 leading lead VBG cord-015021-pol2qm74 7325 17 to to IN cord-015021-pol2qm74 7325 18 , , , cord-015021-pol2qm74 7325 19 perhaps perhaps RB cord-015021-pol2qm74 7325 20 , , , cord-015021-pol2qm74 7325 21 enhanced enhanced JJ cord-015021-pol2qm74 7325 22 protection protection NN cord-015021-pol2qm74 7325 23 to to IN cord-015021-pol2qm74 7325 24 microbial microbial JJ cord-015021-pol2qm74 7325 25 insult insult NN cord-015021-pol2qm74 7325 26 . . . cord-015021-pol2qm74 7326 1 RhG RhG NNP cord-015021-pol2qm74 7326 2 - - HYPH cord-015021-pol2qm74 7326 3 CSF CSF NNP cord-015021-pol2qm74 7326 4 crossed cross VBD cord-015021-pol2qm74 7326 5 the the DT cord-015021-pol2qm74 7326 6 placenta placenta NN cord-015021-pol2qm74 7326 7 and and CC cord-015021-pol2qm74 7326 8 reached reach VBN cord-015021-pol2qm74 7326 9 peak peak JJ cord-015021-pol2qm74 7326 10 fetal fetal JJ cord-015021-pol2qm74 7326 11 serum serum NN cord-015021-pol2qm74 7326 12 concentrations concentration NNS cord-015021-pol2qm74 7326 13 4 4 CD cord-015021-pol2qm74 7326 14 hours hour NNS cord-015021-pol2qm74 7326 15 after after IN cord-015021-pol2qm74 7326 16 administration administration NN cord-015021-pol2qm74 7326 17 . . . cord-015021-pol2qm74 7327 1 These these DT cord-015021-pol2qm74 7327 2 levels level NNS cord-015021-pol2qm74 7327 3 were be VBD cord-015021-pol2qm74 7327 4 1000-fold 1000-fold CD cord-015021-pol2qm74 7327 5 lower low JJR cord-015021-pol2qm74 7327 6 than than IN cord-015021-pol2qm74 7327 7 the the DT cord-015021-pol2qm74 7327 8 levels level NNS cord-015021-pol2qm74 7327 9 detected detect VBN cord-015021-pol2qm74 7327 10 in in IN cord-015021-pol2qm74 7327 11 the the DT cord-015021-pol2qm74 7327 12 adult adult NN cord-015021-pol2qm74 7327 13 dams dam NNS cord-015021-pol2qm74 7327 14 serum serum NN cord-015021-pol2qm74 7327 15 . . . cord-015021-pol2qm74 7328 1 White white JJ cord-015021-pol2qm74 7328 2 blood blood NN cord-015021-pol2qm74 7328 3 cell cell NN cord-015021-pol2qm74 7328 4 counts count NNS cord-015021-pol2qm74 7328 5 were be VBD cord-015021-pol2qm74 7328 6 elevated elevate VBN cord-015021-pol2qm74 7328 7 approximately approximately RB cord-015021-pol2qm74 7328 8 2 2 CD cord-015021-pol2qm74 7328 9 - - HYPH cord-015021-pol2qm74 7328 10 4-fold 4-fold CD cord-015021-pol2qm74 7328 11 over over IN cord-015021-pol2qm74 7328 12 control control NN cord-015021-pol2qm74 7328 13 newborn newborn JJ cord-015021-pol2qm74 7328 14 blood blood NN cord-015021-pol2qm74 7328 15 . . . cord-015021-pol2qm74 7329 1 This this DT cord-015021-pol2qm74 7329 2 increase increase NN cord-015021-pol2qm74 7329 3 was be VBD cord-015021-pol2qm74 7329 4 due due JJ cord-015021-pol2qm74 7329 5 to to IN cord-015021-pol2qm74 7329 6 circulating circulate VBG cord-015021-pol2qm74 7329 7 numbers number NNS cord-015021-pol2qm74 7329 8 of of IN cord-015021-pol2qm74 7329 9 neutrophils neutrophil NNS cord-015021-pol2qm74 7329 10 . . . cord-015021-pol2qm74 7330 1 The the DT cord-015021-pol2qm74 7330 2 marrows marrow NNS cord-015021-pol2qm74 7330 3 from from IN cord-015021-pol2qm74 7330 4 these these DT cord-015021-pol2qm74 7330 5 pups pup NNS cord-015021-pol2qm74 7330 6 were be VBD cord-015021-pol2qm74 7330 7 hyperplastic hyperplastic JJ cord-015021-pol2qm74 7330 8 consisting consist VBG cord-015021-pol2qm74 7330 9 of of IN cord-015021-pol2qm74 7330 10 predominately predominately RB cord-015021-pol2qm74 7330 11 immature immature JJ cord-015021-pol2qm74 7330 12 and and CC cord-015021-pol2qm74 7330 13 mature mature JJ cord-015021-pol2qm74 7330 14 neutrophilic neutrophilic JJ cord-015021-pol2qm74 7330 15 cells cell NNS cord-015021-pol2qm74 7330 16 . . . cord-015021-pol2qm74 7331 1 No no DT cord-015021-pol2qm74 7331 2 changes change NNS cord-015021-pol2qm74 7331 3 were be VBD cord-015021-pol2qm74 7331 4 seen see VBN cord-015021-pol2qm74 7331 5 in in IN cord-015021-pol2qm74 7331 6 the the DT cord-015021-pol2qm74 7331 7 thymus thymus NN cord-015021-pol2qm74 7331 8 or or CC cord-015021-pol2qm74 7331 9 livers liver NNS cord-015021-pol2qm74 7331 10 . . . cord-015021-pol2qm74 7332 1 Pups pup NNS cord-015021-pol2qm74 7332 2 born bear VBN cord-015021-pol2qm74 7332 3 to to IN cord-015021-pol2qm74 7332 4 mothers mother NNS cord-015021-pol2qm74 7332 5 treated treat VBN cord-015021-pol2qm74 7332 6 with with IN cord-015021-pol2qm74 7332 7 rhG rhG NNP cord-015021-pol2qm74 7332 8 - - HYPH cord-015021-pol2qm74 7332 9 CSF CSF NNP cord-015021-pol2qm74 7332 10 since since IN cord-015021-pol2qm74 7332 11 day day NN cord-015021-pol2qm74 7332 12 15 15 CD cord-015021-pol2qm74 7332 13 of of IN cord-015021-pol2qm74 7332 14 gestation gestation NN cord-015021-pol2qm74 7332 15 ( ( -LRB- cord-015021-pol2qm74 7332 16 parturition parturition NN cord-015021-pol2qm74 7332 17 in in IN cord-015021-pol2qm74 7332 18 rodents rodent NNS cord-015021-pol2qm74 7332 19 occurs occur VBZ cord-015021-pol2qm74 7332 20 on on IN cord-015021-pol2qm74 7332 21 approximately approximately RB cord-015021-pol2qm74 7332 22 day day NN cord-015021-pol2qm74 7332 23 21 21 CD cord-015021-pol2qm74 7332 24 ) ) -RRB- cord-015021-pol2qm74 7332 25 survived survive VBD cord-015021-pol2qm74 7332 26 a a DT cord-015021-pol2qm74 7332 27 lethal lethal JJ cord-015021-pol2qm74 7332 28 challenge challenge NN cord-015021-pol2qm74 7332 29 of of IN cord-015021-pol2qm74 7332 30 group group NN cord-015021-pol2qm74 7332 31 B-13 b-13 NN cord-015021-pol2qm74 7332 32 hemolytic hemolytic JJ cord-015021-pol2qm74 7332 33 Streptococcus streptococcus NN cord-015021-pol2qm74 7332 34 . . . cord-015021-pol2qm74 7333 1 In in IN cord-015021-pol2qm74 7333 2 contrast contrast NN cord-015021-pol2qm74 7333 3 their -PRON- PRP$ cord-015021-pol2qm74 7333 4 untreated untreated JJ cord-015021-pol2qm74 7333 5 yet yet CC cord-015021-pol2qm74 7333 6 infected infect VBN cord-015021-pol2qm74 7333 7 counterparts counterpart NNS cord-015021-pol2qm74 7333 8 did do VBD cord-015021-pol2qm74 7333 9 not not RB cord-015021-pol2qm74 7333 10 survive survive VB cord-015021-pol2qm74 7333 11 . . . cord-015021-pol2qm74 7334 1 Recent recent JJ cord-015021-pol2qm74 7334 2 clinical clinical JJ cord-015021-pol2qm74 7334 3 developments development NNS cord-015021-pol2qm74 7334 4 have have VBP cord-015021-pol2qm74 7334 5 led lead VBN cord-015021-pol2qm74 7334 6 to to IN cord-015021-pol2qm74 7334 7 trials trial NNS cord-015021-pol2qm74 7334 8 of of IN cord-015021-pol2qm74 7334 9 rhG rhG NNP cord-015021-pol2qm74 7334 10 - - HYPH cord-015021-pol2qm74 7334 11 CSF csf NN cord-015021-pol2qm74 7334 12 in in IN cord-015021-pol2qm74 7334 13 certain certain JJ cord-015021-pol2qm74 7334 14 neutropenic neutropenic JJ cord-015021-pol2qm74 7334 15 states state NNS cord-015021-pol2qm74 7334 16 including include VBG cord-015021-pol2qm74 7334 17 cyclic cyclic JJ cord-015021-pol2qm74 7334 18 and and CC cord-015021-pol2qm74 7334 19 chronic chronic JJ cord-015021-pol2qm74 7334 20 neutropenia neutropenia NN cord-015021-pol2qm74 7334 21 . . . cord-015021-pol2qm74 7335 1 We -PRON- PRP cord-015021-pol2qm74 7335 2 have have VBP cord-015021-pol2qm74 7335 3 identified identify VBN cord-015021-pol2qm74 7335 4 several several JJ cord-015021-pol2qm74 7335 5 of of IN cord-015021-pol2qm74 7335 6 these these DT cord-015021-pol2qm74 7335 7 patients patient NNS cord-015021-pol2qm74 7335 8 who who WP cord-015021-pol2qm74 7335 9 were be VBD cord-015021-pol2qm74 7335 10 pregnant pregnant JJ cord-015021-pol2qm74 7335 11 during during IN cord-015021-pol2qm74 7335 12 treatment treatment NN cord-015021-pol2qm74 7335 13 with with IN cord-015021-pol2qm74 7335 14 rhG rhG NNP cord-015021-pol2qm74 7335 15 - - HYPH cord-015021-pol2qm74 7335 16 CSF csf NN cord-015021-pol2qm74 7335 17 . . . cord-015021-pol2qm74 7336 1 Biologically biologically RB cord-015021-pol2qm74 7336 2 and and CC cord-015021-pol2qm74 7336 3 anfigenically anfigenically RB cord-015021-pol2qm74 7336 4 identifiable identifiable JJ cord-015021-pol2qm74 7336 5 rhG rhg CD cord-015021-pol2qm74 7336 6 - - HYPH cord-015021-pol2qm74 7336 7 CSF CSF NNP cord-015021-pol2qm74 7336 8 was be VBD cord-015021-pol2qm74 7336 9 detected detect VBN cord-015021-pol2qm74 7336 10 at at IN cord-015021-pol2qm74 7336 11 increased increase VBN cord-015021-pol2qm74 7336 12 levels level NNS cord-015021-pol2qm74 7336 13 in in IN cord-015021-pol2qm74 7336 14 the the DT cord-015021-pol2qm74 7336 15 cord cord NN cord-015021-pol2qm74 7336 16 serum serum NN cord-015021-pol2qm74 7336 17 of of IN cord-015021-pol2qm74 7336 18 these these DT cord-015021-pol2qm74 7336 19 neonates neonate NNS cord-015021-pol2qm74 7336 20 . . . cord-015021-pol2qm74 7337 1 We -PRON- PRP cord-015021-pol2qm74 7337 2 will will MD cord-015021-pol2qm74 7337 3 discuss discuss VB cord-015021-pol2qm74 7337 4 our -PRON- PRP$ cord-015021-pol2qm74 7337 5 findings finding NNS cord-015021-pol2qm74 7337 6 with with IN cord-015021-pol2qm74 7337 7 these these DT cord-015021-pol2qm74 7337 8 patients patient NNS cord-015021-pol2qm74 7337 9 in in IN cord-015021-pol2qm74 7337 10 light light NN cord-015021-pol2qm74 7337 11 of of IN cord-015021-pol2qm74 7337 12 our -PRON- PRP$ cord-015021-pol2qm74 7337 13 animal animal NN cord-015021-pol2qm74 7337 14 model model NN cord-015021-pol2qm74 7337 15 of of IN cord-015021-pol2qm74 7337 16 neonatal neonatal JJ cord-015021-pol2qm74 7337 17 myeloid myeloid NN cord-015021-pol2qm74 7337 18 development development NN cord-015021-pol2qm74 7337 19 . . . cord-015021-pol2qm74 7338 1 We -PRON- PRP cord-015021-pol2qm74 7338 2 have have VBP cord-015021-pol2qm74 7338 3 previously previously RB cord-015021-pol2qm74 7338 4 demonstrated demonstrate VBN cord-015021-pol2qm74 7338 5 decreased decrease VBD cord-015021-pol2qm74 7338 6 G G NNP cord-015021-pol2qm74 7338 7 - - HYPH cord-015021-pol2qm74 7338 8 CSF csf NN cord-015021-pol2qm74 7338 9 production production NN cord-015021-pol2qm74 7338 10 and and CC cord-015021-pol2qm74 7338 11 G G NNP cord-015021-pol2qm74 7338 12 - - HYPH cord-015021-pol2qm74 7338 13 CSF CSF NNP cord-015021-pol2qm74 7338 14 mRNA mrna NN cord-015021-pol2qm74 7338 15 expression expression NN cord-015021-pol2qm74 7338 16 from from IN cord-015021-pol2qm74 7338 17 activated activate VBN cord-015021-pol2qm74 7338 18 mononuclear mononuclear JJ cord-015021-pol2qm74 7338 19 cells cell NNS cord-015021-pol2qm74 7338 20 from from IN cord-015021-pol2qm74 7338 21 newboms newboms NN cord-015021-pol2qm74 7338 22 compared compare VBN cord-015021-pol2qm74 7338 23 to to IN cord-015021-pol2qm74 7338 24 adults adult NNS cord-015021-pol2qm74 7338 25 ( ( -LRB- cord-015021-pol2qm74 7338 26 Cairo Cairo NNP cord-015021-pol2qm74 7338 27 , , , cord-015021-pol2qm74 7338 28 Pediatr Pediatr NNP cord-015021-pol2qm74 7338 29 Res Res NNP cord-015021-pol2qm74 7338 30 31:574 31:574 NN cord-015021-pol2qm74 7338 31 , , , cord-015021-pol2qm74 7338 32 1992 1992 CD cord-015021-pol2qm74 7338 33 ) ) -RRB- cord-015021-pol2qm74 7338 34 . . . cord-015021-pol2qm74 7339 1 We -PRON- PRP cord-015021-pol2qm74 7339 2 have have VBP cord-015021-pol2qm74 7339 3 also also RB cord-015021-pol2qm74 7339 4 recently recently RB cord-015021-pol2qm74 7339 5 observed observe VBN cord-015021-pol2qm74 7339 6 that that IN cord-015021-pol2qm74 7339 7 administration administration NN cord-015021-pol2qm74 7339 8 of of IN cord-015021-pol2qm74 7339 9 a a DT cord-015021-pol2qm74 7339 10 single single JJ cord-015021-pol2qm74 7339 11 dose dose NN cord-015021-pol2qm74 7339 12 of of IN cord-015021-pol2qm74 7339 13 rhG rhG NNP cord-015021-pol2qm74 7339 14 - - HYPH cord-015021-pol2qm74 7339 15 CSE CSE NNP cord-015021-pol2qm74 7339 16 to to IN cord-015021-pol2qm74 7339 17 one one CD cord-015021-pol2qm74 7339 18 - - HYPH cord-015021-pol2qm74 7339 19 day day NN cord-015021-pol2qm74 7339 20 - - HYPH cord-015021-pol2qm74 7339 21 old old JJ cord-015021-pol2qm74 7339 22 newborn newborn JJ cord-015021-pol2qm74 7339 23 rats rat NNS cord-015021-pol2qm74 7339 24 induced induce VBD cord-015021-pol2qm74 7339 25 significant significant JJ cord-015021-pol2qm74 7339 26 neatrophilia neatrophilia NNP cord-015021-pol2qm74 7339 27 , , , cord-015021-pol2qm74 7339 28 while while IN cord-015021-pol2qm74 7339 29 administration administration NN cord-015021-pol2qm74 7339 30 for for IN cord-015021-pol2qm74 7339 31 7 7 CD cord-015021-pol2qm74 7339 32 days day NNS cord-015021-pol2qm74 7339 33 induced induce VBN cord-015021-pol2qm74 7339 34 neulrophilia neulrophilia NNP cord-015021-pol2qm74 7339 35 and and CC cord-015021-pol2qm74 7339 36 increased increase VBD cord-015021-pol2qm74 7339 37 the the DT cord-015021-pol2qm74 7339 38 bone bone NN cord-015021-pol2qm74 7339 39 marrow marrow NN cord-015021-pol2qm74 7339 40 ( ( -LRB- cord-015021-pol2qm74 7339 41 BM BM NNP cord-015021-pol2qm74 7339 42 ) ) -RRB- cord-015021-pol2qm74 7339 43 neutrophil neutrophil NN cord-015021-pol2qm74 7339 44 storage storage NN cord-015021-pol2qm74 7339 45 and and CC cord-015021-pol2qm74 7339 46 progenitor progenitor NN cord-015021-pol2qm74 7339 47 pools pool NNS cord-015021-pol2qm74 7340 1 ( ( -LRB- cord-015021-pol2qm74 7340 2 Cairo Cairo NNP cord-015021-pol2qm74 7340 3 , , , cord-015021-pol2qm74 7340 4 Blood blood NN cord-015021-pol2qm74 7340 5 76:1788 76:1788 CD cord-015021-pol2qm74 7340 6 , , , cord-015021-pol2qm74 7340 7 1990 1990 CD cord-015021-pol2qm74 7340 8 Cairo Cairo NNP cord-015021-pol2qm74 7340 9 , , , cord-015021-pol2qm74 7340 10 Pediatr Pediatr NNP cord-015021-pol2qm74 7340 11 Res Res NNP cord-015021-pol2qm74 7340 12 27:612 27:612 CD cord-015021-pol2qm74 7340 13 , , , cord-015021-pol2qm74 7340 14 1990 1990 CD cord-015021-pol2qm74 7340 15 ) ) -RRB- cord-015021-pol2qm74 7340 16 . . . cord-015021-pol2qm74 7341 1 We -PRON- PRP cord-015021-pol2qm74 7341 2 embarked embark VBD cord-015021-pol2qm74 7341 3 on on IN cord-015021-pol2qm74 7341 4 a a DT cord-015021-pol2qm74 7341 5 phase phase NN cord-015021-pol2qm74 7341 6 I -PRON- PRP cord-015021-pol2qm74 7341 7 trial trial NN cord-015021-pol2qm74 7341 8 exploring explore VBG cord-015021-pol2qm74 7341 9 the the DT cord-015021-pol2qm74 7341 10 safety safety NN cord-015021-pol2qm74 7341 11 , , , cord-015021-pol2qm74 7341 12 pharmacokinetics pharmacokinetic NNS cord-015021-pol2qm74 7341 13 , , , cord-015021-pol2qm74 7341 14 and and CC cord-015021-pol2qm74 7341 15 biological biological JJ cord-015021-pol2qm74 7341 16 efficacy efficacy NN cord-015021-pol2qm74 7341 17 of of IN cord-015021-pol2qm74 7341 18 G G NNP cord-015021-pol2qm74 7341 19 - - HYPH cord-015021-pol2qm74 7341 20 CSF CSF NNP cord-015021-pol2qm74 7341 21 in in IN cord-015021-pol2qm74 7341 22 newborns newborn NNS cord-015021-pol2qm74 7341 23 with with IN cord-015021-pol2qm74 7341 24 presumed presume VBN cord-015021-pol2qm74 7341 25 sepsis sepsis NN cord-015021-pol2qm74 7341 26 . . . cord-015021-pol2qm74 7342 1 42 42 CD cord-015021-pol2qm74 7342 2 infants infant NNS cord-015021-pol2qm74 7342 3 < < XX cord-015021-pol2qm74 7342 4 72 72 CD cord-015021-pol2qm74 7342 5 hrs hrs NN cord-015021-pol2qm74 7342 6 old old JJ cord-015021-pol2qm74 7342 7 with with IN cord-015021-pol2qm74 7342 8 a a DT cord-015021-pol2qm74 7342 9 diagnosis diagnosis NN cord-015021-pol2qm74 7342 10 of of IN cord-015021-pol2qm74 7342 11 presumed presume VBN cord-015021-pol2qm74 7342 12 sepsis sepsis NN cord-015021-pol2qm74 7342 13 were be VBD cord-015021-pol2qm74 7342 14 stratified stratify VBN cord-015021-pol2qm74 7342 15 into into IN cord-015021-pol2qm74 7342 16 three three CD cord-015021-pol2qm74 7342 17 groups group NNS cord-015021-pol2qm74 7342 18 : : : cord-015021-pol2qm74 7342 19 very very RB cord-015021-pol2qm74 7342 20 preterm preterm JJ cord-015021-pol2qm74 7342 21 ( ( -LRB- cord-015021-pol2qm74 7342 22 26 26 CD cord-015021-pol2qm74 7342 23 - - SYM cord-015021-pol2qm74 7342 24 30 30 CD cord-015021-pol2qm74 7342 25 wk wk NN cord-015021-pol2qm74 7342 26 ) ) -RRB- cord-015021-pol2qm74 7342 27 , , , cord-015021-pol2qm74 7342 28 preterm preterm NNS cord-015021-pol2qm74 7342 29 ( ( -LRB- cord-015021-pol2qm74 7342 30 31 31 CD cord-015021-pol2qm74 7342 31 - - SYM cord-015021-pol2qm74 7342 32 35 35 CD cord-015021-pol2qm74 7342 33 wk wk NNS cord-015021-pol2qm74 7342 34 ) ) -RRB- cord-015021-pol2qm74 7342 35 , , , cord-015021-pol2qm74 7342 36 and and CC cord-015021-pol2qm74 7342 37 term term NN cord-015021-pol2qm74 7342 38 ( ( -LRB- cord-015021-pol2qm74 7342 39 > > NFP cord-015021-pol2qm74 7342 40 36 36 CD cord-015021-pol2qm74 7342 41 wk wk NN cord-015021-pol2qm74 7342 42 ) ) -RRB- cord-015021-pol2qm74 7342 43 and and CC cord-015021-pol2qm74 7342 44 randomized randomize VBD cord-015021-pol2qm74 7342 45 to to TO cord-015021-pol2qm74 7342 46 receive receive VB cord-015021-pol2qm74 7342 47 either either CC cord-015021-pol2qm74 7342 48 a a DT cord-015021-pol2qm74 7342 49 placebo placebo NN cord-015021-pol2qm74 7342 50 or or CC cord-015021-pol2qm74 7342 51 1 1 CD cord-015021-pol2qm74 7342 52 , , , cord-015021-pol2qm74 7342 53 5 5 CD cord-015021-pol2qm74 7342 54 , , , cord-015021-pol2qm74 7342 55 and and CC cord-015021-pol2qm74 7342 56 10 10 CD cord-015021-pol2qm74 7342 57 gg gg NNP cord-015021-pol2qm74 7342 58 / / SYM cord-015021-pol2qm74 7342 59 kg kg NNP cord-015021-pol2qm74 7342 60 / / SYM cord-015021-pol2qm74 7342 61 qd qd NN cord-015021-pol2qm74 7342 62 or or CC cord-015021-pol2qm74 7342 63 5 5 CD cord-015021-pol2qm74 7342 64 and and CC cord-015021-pol2qm74 7342 65 10 10 CD cord-015021-pol2qm74 7343 1 p.g p.g NNP cord-015021-pol2qm74 7343 2 / / SYM cord-015021-pol2qm74 7343 3 kg kg NNP cord-015021-pol2qm74 7343 4 / / SYM cord-015021-pol2qm74 7343 5 bid bid NN cord-015021-pol2qm74 7343 6 of of IN cord-015021-pol2qm74 7343 7 rhG rhG NNP cord-015021-pol2qm74 7343 8 - - HYPH cord-015021-pol2qm74 7343 9 CSF csf NN cord-015021-pol2qm74 7343 10 infused infuse VBN cord-015021-pol2qm74 7343 11 by by IN cord-015021-pol2qm74 7343 12 pump pump NN cord-015021-pol2qm74 7343 13 over over IN cord-015021-pol2qm74 7343 14 1 1 CD cord-015021-pol2qm74 7343 15 hour hour NN cord-015021-pol2qm74 7343 16 for for IN cord-015021-pol2qm74 7343 17 3 3 CD cord-015021-pol2qm74 7343 18 consecutive consecutive JJ cord-015021-pol2qm74 7343 19 days day NNS cord-015021-pol2qm74 7343 20 . . . cord-015021-pol2qm74 7344 1 CBCs cbc NNS cord-015021-pol2qm74 7344 2 were be VBD cord-015021-pol2qm74 7344 3 obtained obtain VBN cord-015021-pol2qm74 7344 4 at at IN cord-015021-pol2qm74 7344 5 2 2 CD cord-015021-pol2qm74 7344 6 , , , cord-015021-pol2qm74 7344 7 6 6 CD cord-015021-pol2qm74 7344 8 , , , cord-015021-pol2qm74 7344 9 24 24 CD cord-015021-pol2qm74 7344 10 , , , cord-015021-pol2qm74 7344 11 48 48 CD cord-015021-pol2qm74 7344 12 , , , cord-015021-pol2qm74 7344 13 72 72 CD cord-015021-pol2qm74 7344 14 and and CC cord-015021-pol2qm74 7344 15 96 96 CD cord-015021-pol2qm74 7344 16 hrs hrs NN cord-015021-pol2qm74 7344 17 . . . cord-015021-pol2qm74 7345 1 Tibial tibial JJ cord-015021-pol2qm74 7345 2 bone bone NN cord-015021-pol2qm74 7345 3 marrow marrow NN cord-015021-pol2qm74 7345 4 aspirations aspiration NNS cord-015021-pol2qm74 7345 5 were be VBD cord-015021-pol2qm74 7345 6 performed perform VBN cord-015021-pol2qm74 7345 7 72 72 CD cord-015021-pol2qm74 7345 8 hrs hrs NN cord-015021-pol2qm74 7345 9 after after IN cord-015021-pol2qm74 7345 10 study study NN cord-015021-pol2qm74 7345 11 entry entry NN cord-015021-pol2qm74 7345 12 and and CC cord-015021-pol2qm74 7345 13 differential differential JJ cord-015021-pol2qm74 7345 14 counts count NNS cord-015021-pol2qm74 7345 15 and and CC cord-015021-pol2qm74 7345 16 CFU CFU NNP cord-015021-pol2qm74 7345 17 - - HYPH cord-015021-pol2qm74 7345 18 GM GM NNP cord-015021-pol2qm74 7345 19 pools pool NNS cord-015021-pol2qm74 7345 20 were be VBD cord-015021-pol2qm74 7345 21 determined determine VBN cord-015021-pol2qm74 7345 22 . . . cord-015021-pol2qm74 7346 1 C3bi C3bi NNP cord-015021-pol2qm74 7346 2 expression expression NN cord-015021-pol2qm74 7346 3 was be VBD cord-015021-pol2qm74 7346 4 determined determine VBN cord-015021-pol2qm74 7346 5 at at IN cord-015021-pol2qm74 7346 6 0 0 CD cord-015021-pol2qm74 7346 7 and and CC cord-015021-pol2qm74 7346 8 24 24 CD cord-015021-pol2qm74 7346 9 hrs hrs NN cord-015021-pol2qm74 7346 10 after after IN cord-015021-pol2qm74 7346 11 rhG rhG NNP cord-015021-pol2qm74 7346 12 - - HYPH cord-015021-pol2qm74 7346 13 CSF CSF NNP cord-015021-pol2qm74 7346 14 , , , cord-015021-pol2qm74 7346 15 and and CC cord-015021-pol2qm74 7346 16 G G NNP cord-015021-pol2qm74 7346 17 - - HYPH cord-015021-pol2qm74 7346 18 CSF csf NN cord-015021-pol2qm74 7346 19 pharmacokinetics pharmacokinetic NNS cord-015021-pol2qm74 7346 20 were be VBD cord-015021-pol2qm74 7346 21 performed perform VBN cord-015021-pol2qm74 7346 22 after after IN cord-015021-pol2qm74 7346 23 the the DT cord-015021-pol2qm74 7346 24 first first JJ cord-015021-pol2qm74 7346 25 dose dose NN cord-015021-pol2qm74 7346 26 of of IN cord-015021-pol2qm74 7346 27 rhG rhG NNP cord-015021-pol2qm74 7346 28 - - HYPH cord-015021-pol2qm74 7346 29 CSF csf NN cord-015021-pol2qm74 7346 30 utilizing utilize VBG cord-015021-pol2qm74 7346 31 a a DT cord-015021-pol2qm74 7346 32 sandwich sandwich NN cord-015021-pol2qm74 7346 33 ELISA ELISA NNP cord-015021-pol2qm74 7346 34 . . . cord-015021-pol2qm74 7347 1 A a DT cord-015021-pol2qm74 7347 2 significant significant JJ cord-015021-pol2qm74 7347 3 increase increase NN cord-015021-pol2qm74 7347 4 in in IN cord-015021-pol2qm74 7347 5 the the DT cord-015021-pol2qm74 7347 6 ANC ANC NNP cord-015021-pol2qm74 7347 7 was be VBD cord-015021-pol2qm74 7347 8 observed observe VBN cord-015021-pol2qm74 7347 9 at at IN cord-015021-pol2qm74 7347 10 48 48 CD cord-015021-pol2qm74 7347 11 , , , cord-015021-pol2qm74 7347 12 72 72 CD cord-015021-pol2qm74 7347 13 and and CC cord-015021-pol2qm74 7347 14 96 96 CD cord-015021-pol2qm74 7347 15 hrs hrs NN cord-015021-pol2qm74 7347 16 following follow VBG cord-015021-pol2qm74 7347 17 administration administration NN cord-015021-pol2qm74 7347 18 of of IN cord-015021-pol2qm74 7347 19 both both DT cord-015021-pol2qm74 7347 20 5 5 CD cord-015021-pol2qm74 7347 21 and and CC cord-015021-pol2qm74 7347 22 10 10 CD cord-015021-pol2qm74 7348 1 ~tg ~tg NNP cord-015021-pol2qm74 7348 2 / / SYM cord-015021-pol2qm74 7348 3 kg kg NN cord-015021-pol2qm74 7348 4 / / SYM cord-015021-pol2qm74 7348 5 d d NN cord-015021-pol2qm74 7348 6 of of IN cord-015021-pol2qm74 7348 7 rhG rhG NNP cord-015021-pol2qm74 7348 8 - - HYPH cord-015021-pol2qm74 7348 9 CSF CSF NNP cord-015021-pol2qm74 7348 10 . . . cord-015021-pol2qm74 7349 1 The the DT cord-015021-pol2qm74 7349 2 maximum maximum JJ cord-015021-pol2qm74 7349 3 increase increase NN cord-015021-pol2qm74 7349 4 in in IN cord-015021-pol2qm74 7349 5 the the DT cord-015021-pol2qm74 7349 6 ANC ANC NNP cord-015021-pol2qm74 7349 7 occurred occur VBD cord-015021-pol2qm74 7349 8 72 72 CD cord-015021-pol2qm74 7349 9 hrs hrs NN cord-015021-pol2qm74 7349 10 after after IN cord-015021-pol2qm74 7349 11 5 5 CD cord-015021-pol2qm74 7349 12 and and CC cord-015021-pol2qm74 7349 13 10 10 CD cord-015021-pol2qm74 7349 14 ~tg ~tg NNS cord-015021-pol2qm74 7350 1 /kg /kg NFP cord-015021-pol2qm74 7350 2 / / SYM cord-015021-pol2qm74 7350 3 d d NN cord-015021-pol2qm74 7350 4 ( ( -LRB- cord-015021-pol2qm74 7350 5 397 397 CD cord-015021-pol2qm74 7350 6 -116 -116 NN cord-015021-pol2qm74 7350 7 % % NN cord-015021-pol2qm74 7350 8 ) ) -RRB- cord-015021-pol2qm74 7350 9 ( ( -LRB- cord-015021-pol2qm74 7350 10 p<0.01 p<0.01 NNP cord-015021-pol2qm74 7350 11 ) ) -RRB- cord-015021-pol2qm74 7350 12 and and CC cord-015021-pol2qm74 7350 13 ( ( -LRB- cord-015021-pol2qm74 7350 14 621 621 CD cord-015021-pol2qm74 7350 15 % % NN cord-015021-pol2qm74 7350 16 -+ -+ . cord-015021-pol2qm74 7350 17 200 200 CD cord-015021-pol2qm74 7350 18 % % NN cord-015021-pol2qm74 7350 19 ) ) -RRB- cord-015021-pol2qm74 7350 20 ( ( -LRB- cord-015021-pol2qm74 7350 21 p<0.001 p<0.001 JJ cord-015021-pol2qm74 7350 22 ) ) -RRB- cord-015021-pol2qm74 7350 23 , , , cord-015021-pol2qm74 7350 24 respectively respectively RB cord-015021-pol2qm74 7350 25 . . . cord-015021-pol2qm74 7351 1 There there EX cord-015021-pol2qm74 7351 2 was be VBD cord-015021-pol2qm74 7351 3 a a DT cord-015021-pol2qm74 7351 4 significant significant JJ cord-015021-pol2qm74 7351 5 dose dose NN cord-015021-pol2qm74 7351 6 - - HYPH cord-015021-pol2qm74 7351 7 dapendeat dapendeat NN cord-015021-pol2qm74 7351 8 increase increase NN cord-015021-pol2qm74 7351 9 in in IN cord-015021-pol2qm74 7351 10 the the DT cord-015021-pol2qm74 7351 11 BM BM NNP cord-015021-pol2qm74 7351 12 neutrophil neutrophil NN cord-015021-pol2qm74 7351 13 storage storage NN cord-015021-pol2qm74 7351 14 pool pool NN cord-015021-pol2qm74 7351 15 ( ( -LRB- cord-015021-pol2qm74 7351 16 18 18 CD cord-015021-pol2qm74 7351 17 _ _ NN cord-015021-pol2qm74 7351 18 + + SYM cord-015021-pol2qm74 7351 19 4 4 CD cord-015021-pol2qm74 7351 20 % % NN cord-015021-pol2qm74 7351 21 vs. vs. CC cord-015021-pol2qm74 7351 22 62 62 CD cord-015021-pol2qm74 7351 23 + + SYM cord-015021-pol2qm74 7351 24 6 6 CD cord-015021-pol2qm74 7351 25 % % NN cord-015021-pol2qm74 7351 26 ) ) -RRB- cord-015021-pol2qm74 7351 27 ( ( -LRB- cord-015021-pol2qm74 7351 28 p<0.01 p<0.01 NN cord-015021-pol2qm74 7351 29 ) ) -RRB- cord-015021-pol2qm74 7352 1 ( ( -LRB- cord-015021-pol2qm74 7352 2 placebo placebo NN cord-015021-pol2qm74 7352 3 vs. vs. IN cord-015021-pol2qm74 7352 4 10 10 CD cord-015021-pol2qm74 7353 1 ~tg ~tg NNP cord-015021-pol2qm74 7353 2 / / SYM cord-015021-pol2qm74 7353 3 kg kg NN cord-015021-pol2qm74 7353 4 / / SYM cord-015021-pol2qm74 7353 5 d d NN cord-015021-pol2qm74 7353 6 ) ) -RRB- cord-015021-pol2qm74 7353 7 . . . cord-015021-pol2qm74 7354 1 There there EX cord-015021-pol2qm74 7354 2 was be VBD cord-015021-pol2qm74 7354 3 no no DT cord-015021-pol2qm74 7354 4 significant significant JJ cord-015021-pol2qm74 7354 5 difference difference NN cord-015021-pol2qm74 7354 6 in in IN cord-015021-pol2qm74 7354 7 the the DT cord-015021-pol2qm74 7354 8 nantrophil nantrophil NNP cord-015021-pol2qm74 7354 9 proliferative proliferative JJ cord-015021-pol2qm74 7354 10 pool pool NN cord-015021-pol2qm74 7354 11 . . . cord-015021-pol2qm74 7355 1 An an DT cord-015021-pol2qm74 7355 2 increase increase NN cord-015021-pol2qm74 7355 3 in in IN cord-015021-pol2qm74 7355 4 CFU CFU NNP cord-015021-pol2qm74 7355 5 - - HYPH cord-015021-pol2qm74 7355 6 GM GM NNP cord-015021-pol2qm74 7355 7 and and CC cord-015021-pol2qm74 7355 8 CFU CFU NNP cord-015021-pol2qm74 7355 9 - - HYPH cord-015021-pol2qm74 7355 10 GEMM GEMM NNP cord-015021-pol2qm74 7355 11 was be VBD cord-015021-pol2qm74 7355 12 seen see VBN cord-015021-pol2qm74 7355 13 at at IN cord-015021-pol2qm74 7355 14 all all DT cord-015021-pol2qm74 7355 15 doses dose NNS cord-015021-pol2qm74 7355 16 tested test VBN cord-015021-pol2qm74 7355 17 , , , cord-015021-pol2qm74 7355 18 compared compare VBN cord-015021-pol2qm74 7355 19 to to IN cord-015021-pol2qm74 7355 20 placebo placebo NN cord-015021-pol2qm74 7355 21 ( ( -LRB- cord-015021-pol2qm74 7355 22 53.5 53.5 CD cord-015021-pol2qm74 7355 23 _ _ NN cord-015021-pol2qm74 7355 24 + + CC cord-015021-pol2qm74 7356 1 8.6 8.6 CD cord-015021-pol2qm74 7356 2 vs. vs. NN cord-015021-pol2qm74 7356 3 87 87 CD cord-015021-pol2qm74 7356 4 -+ -+ . cord-015021-pol2qm74 7356 5 15 15 CD cord-015021-pol2qm74 7356 6 ) ) -RRB- cord-015021-pol2qm74 7356 7 ( ( -LRB- cord-015021-pol2qm74 7356 8 colonies colony NNS cord-015021-pol2qm74 7356 9 / / SYM cord-015021-pol2qm74 7356 10 l(P l(p NN cord-015021-pol2qm74 7356 11 cells cell NNS cord-015021-pol2qm74 7356 12 / / SYM cord-015021-pol2qm74 7356 13 plate plate NN cord-015021-pol2qm74 7356 14 ) ) -RRB- cord-015021-pol2qm74 7356 15 . . . cord-015021-pol2qm74 7357 1 C3bi C3bi NNP cord-015021-pol2qm74 7357 2 expression expression NN cord-015021-pol2qm74 7357 3 was be VBD cord-015021-pol2qm74 7357 4 significantly significantly RB cord-015021-pol2qm74 7357 5 increased increase VBN cord-015021-pol2qm74 7357 6 24 24 CD cord-015021-pol2qm74 7357 7 hrs hrs NN cord-015021-pol2qm74 7357 8 after after IN cord-015021-pol2qm74 7357 9 10 10 CD cord-015021-pol2qm74 7357 10 Bg Bg NNP cord-015021-pol2qm74 7357 11 / / SYM cord-015021-pol2qm74 7357 12 kg kg NN cord-015021-pol2qm74 7357 13 / / SYM cord-015021-pol2qm74 7357 14 d d NN cord-015021-pol2qm74 7357 15 of of IN cord-015021-pol2qm74 7357 16 rhG rhG NNP cord-015021-pol2qm74 7357 17 - - HYPH cord-015021-pol2qm74 7357 18 CSF CSF NNP cord-015021-pol2qm74 7357 19 ( ( -LRB- cord-015021-pol2qm74 7357 20 233 233 CD cord-015021-pol2qm74 7357 21 + + SYM cord-015021-pol2qm74 7357 22 81 81 CD cord-015021-pol2qm74 7357 23 % % NN cord-015021-pol2qm74 7357 24 vs. vs. CC cord-015021-pol2qm74 7357 25 83 83 CD cord-015021-pol2qm74 7357 26 + + SYM cord-015021-pol2qm74 7357 27 -26 -26 CD cord-015021-pol2qm74 7357 28 % % NN cord-015021-pol2qm74 7357 29 ) ) -RRB- cord-015021-pol2qm74 7358 1 ( ( -LRB- cord-015021-pol2qm74 7358 2 p<0.012 p<0.012 NN cord-015021-pol2qm74 7358 3 ) ) -RRB- cord-015021-pol2qm74 7358 4 . . . cord-015021-pol2qm74 7359 1 Peak peak NN cord-015021-pol2qm74 7359 2 serum serum NN cord-015021-pol2qm74 7359 3 G G NNP cord-015021-pol2qm74 7359 4 - - HYPH cord-015021-pol2qm74 7359 5 CSF CSF NNP cord-015021-pol2qm74 7359 6 levels level NNS cord-015021-pol2qm74 7359 7 occurred occur VBD cord-015021-pol2qm74 7359 8 at at IN cord-015021-pol2qm74 7359 9 2 2 CD cord-015021-pol2qm74 7359 10 hrs hrs NN cord-015021-pol2qm74 7359 11 and and CC cord-015021-pol2qm74 7359 12 were be VBD cord-015021-pol2qm74 7359 13 dosedependent dosedependent JJ cord-015021-pol2qm74 7359 14 . . . cord-015021-pol2qm74 7360 1 The the DT cord-015021-pol2qm74 7360 2 half half JJ cord-015021-pol2qm74 7360 3 - - HYPH cord-015021-pol2qm74 7360 4 life life NN cord-015021-pol2qm74 7360 5 of of IN cord-015021-pol2qm74 7360 6 rhG rhG NNP cord-015021-pol2qm74 7360 7 - - HYPH cord-015021-pol2qm74 7360 8 CSE CSE NNP cord-015021-pol2qm74 7360 9 was be VBD cord-015021-pol2qm74 7360 10 4.44 4.44 CD cord-015021-pol2qm74 7360 11 + + SYM cord-015021-pol2qm74 7360 12 0.4 0.4 CD cord-015021-pol2qm74 7360 13 hrs hrs NN cord-015021-pol2qm74 7360 14 . . . cord-015021-pol2qm74 7361 1 Most most RBS cord-015021-pol2qm74 7361 2 importantly importantly RB cord-015021-pol2qm74 7361 3 , , , cord-015021-pol2qm74 7361 4 there there EX cord-015021-pol2qm74 7361 5 was be VBD cord-015021-pol2qm74 7361 6 no no DT cord-015021-pol2qm74 7361 7 observed observed JJ cord-015021-pol2qm74 7361 8 toxicity toxicity NN cord-015021-pol2qm74 7361 9 from from IN cord-015021-pol2qm74 7361 10 G G NNP cord-015021-pol2qm74 7361 11 - - HYPH cord-015021-pol2qm74 7361 12 CSF CSF NNP cord-015021-pol2qm74 7361 13 in in IN cord-015021-pol2qm74 7361 14 all all DT cord-015021-pol2qm74 7361 15 patients patient NNS cord-015021-pol2qm74 7361 16 studied study VBD cord-015021-pol2qm74 7361 17 . . . cord-015021-pol2qm74 7362 1 31 31 CD cord-015021-pol2qm74 7362 2 of of IN cord-015021-pol2qm74 7362 3 42 42 CD cord-015021-pol2qm74 7362 4 patients patient NNS cord-015021-pol2qm74 7362 5 were be VBD cord-015021-pol2qm74 7362 6 on on IN cord-015021-pol2qm74 7362 7 ventilators ventilator NNS cord-015021-pol2qm74 7362 8 prior prior RB cord-015021-pol2qm74 7362 9 to to IN cord-015021-pol2qm74 7362 10 administration administration NN cord-015021-pol2qm74 7362 11 of of IN cord-015021-pol2qm74 7362 12 rhG rhG NNP cord-015021-pol2qm74 7362 13 - - HYPH cord-015021-pol2qm74 7362 14 CSF CSF NNP cord-015021-pol2qm74 7362 15 and and CC cord-015021-pol2qm74 7362 16 there there EX cord-015021-pol2qm74 7362 17 was be VBD cord-015021-pol2qm74 7362 18 no no DT cord-015021-pol2qm74 7362 19 increase increase NN cord-015021-pol2qm74 7362 20 in in IN cord-015021-pol2qm74 7362 21 pulmonary pulmonary JJ cord-015021-pol2qm74 7362 22 toxicity toxicity NN cord-015021-pol2qm74 7362 23 . . . cord-015021-pol2qm74 7363 1 These these DT cord-015021-pol2qm74 7363 2 preliminary preliminary JJ cord-015021-pol2qm74 7363 3 data datum NNS cord-015021-pol2qm74 7363 4 suggest suggest VBP cord-015021-pol2qm74 7363 5 that that IN cord-015021-pol2qm74 7363 6 rhG rhG NNP cord-015021-pol2qm74 7363 7 - - HYPH cord-015021-pol2qm74 7363 8 CSF CSF NNP cord-015021-pol2qm74 7363 9 is be VBZ cord-015021-pol2qm74 7363 10 well well RB cord-015021-pol2qm74 7363 11 tolerated tolerate VBN cord-015021-pol2qm74 7363 12 at at IN cord-015021-pol2qm74 7363 13 all all DT cord-015021-pol2qm74 7363 14 gestational gestational JJ cord-015021-pol2qm74 7363 15 ages age NNS cord-015021-pol2qm74 7363 16 in in IN cord-015021-pol2qm74 7363 17 newborns newborn NNS cord-015021-pol2qm74 7363 18 with with IN cord-015021-pol2qm74 7363 19 presumed presume VBN cord-015021-pol2qm74 7363 20 sepsis sepsis NN cord-015021-pol2qm74 7363 21 . . . cord-015021-pol2qm74 7364 1 A a DT cord-015021-pol2qm74 7364 2 multi multi JJ cord-015021-pol2qm74 7364 3 - - JJ cord-015021-pol2qm74 7364 4 center center JJ cord-015021-pol2qm74 7364 5 phase phase NN cord-015021-pol2qm74 7364 6 II II NNP cord-015021-pol2qm74 7364 7 / / SYM cord-015021-pol2qm74 7364 8 III iii CD cord-015021-pol2qm74 7364 9 randomized randomize VBD cord-015021-pol2qm74 7364 10 double double JJ cord-015021-pol2qm74 7364 11 - - HYPH cord-015021-pol2qm74 7364 12 blindad blindad NN cord-015021-pol2qm74 7364 13 placebo placebo NN cord-015021-pol2qm74 7364 14 controlled control VBN cord-015021-pol2qm74 7364 15 trial trial NN cord-015021-pol2qm74 7364 16 is be VBZ cord-015021-pol2qm74 7364 17 required require VBN cord-015021-pol2qm74 7364 18 to to TO cord-015021-pol2qm74 7364 19 determine determine VB cord-015021-pol2qm74 7364 20 the the DT cord-015021-pol2qm74 7364 21 efficacy efficacy NN cord-015021-pol2qm74 7364 22 of of IN cord-015021-pol2qm74 7364 23 rhG rhG NNP cord-015021-pol2qm74 7364 24 - - HYPH cord-015021-pol2qm74 7364 25 CSF csf NN cord-015021-pol2qm74 7364 26 in in IN cord-015021-pol2qm74 7364 27 this this DT cord-015021-pol2qm74 7364 28 clinical clinical JJ cord-015021-pol2qm74 7364 29 setting setting NN cord-015021-pol2qm74 7364 30 . . . cord-015021-pol2qm74 7364 31 _SP cord-015021-pol2qm74 7365 1 We -PRON- PRP cord-015021-pol2qm74 7365 2 investigated investigate VBD cord-015021-pol2qm74 7365 3 the the DT cord-015021-pol2qm74 7365 4 effects effect NNS cord-015021-pol2qm74 7365 5 of of IN cord-015021-pol2qm74 7365 6 recombinant recombinant JJ cord-015021-pol2qm74 7365 7 canine canine JJ cord-015021-pol2qm74 7365 8 granulocyte granulocyte NN cord-015021-pol2qm74 7365 9 - - HYPH cord-015021-pol2qm74 7365 10 colony colony NN cord-015021-pol2qm74 7365 11 stimulating stimulate VBG cord-015021-pol2qm74 7365 12 factor factor NN cord-015021-pol2qm74 7365 13 ( ( -LRB- cord-015021-pol2qm74 7365 14 G G NNP cord-015021-pol2qm74 7365 15 - - HYPH cord-015021-pol2qm74 7365 16 CSF CSF NNP cord-015021-pol2qm74 7365 17 ) ) -RRB- cord-015021-pol2qm74 7365 18 on on IN cord-015021-pol2qm74 7365 19 survival survival NN cord-015021-pol2qm74 7365 20 , , , cord-015021-pol2qm74 7365 21 cardiopulmonary cardiopulmonary JJ cord-015021-pol2qm74 7365 22 function function NN cord-015021-pol2qm74 7365 23 , , , cord-015021-pol2qm74 7365 24 serum serum NN cord-015021-pol2qm74 7365 25 endotoxin endotoxin NN cord-015021-pol2qm74 7365 26 levels level NNS cord-015021-pol2qm74 7365 27 and and CC cord-015021-pol2qm74 7365 28 tumor tumor NN cord-015021-pol2qm74 7365 29 necrosis necrosis NN cord-015021-pol2qm74 7365 30 factor factor NN cord-015021-pol2qm74 7365 31 ( ( -LRB- cord-015021-pol2qm74 7365 32 TNF TNF NNP cord-015021-pol2qm74 7365 33 ) ) -RRB- cord-015021-pol2qm74 7365 34 levels level NNS cord-015021-pol2qm74 7365 35 in in IN cord-015021-pol2qm74 7365 36 a a DT cord-015021-pol2qm74 7365 37 canine canine JJ cord-015021-pol2qm74 7365 38 model model NN cord-015021-pol2qm74 7365 39 of of IN cord-015021-pol2qm74 7365 40 lethal lethal JJ cord-015021-pol2qm74 7365 41 bacterial bacterial JJ cord-015021-pol2qm74 7365 42 septic septic JJ cord-015021-pol2qm74 7365 43 shock shock NN cord-015021-pol2qm74 7365 44 ( ( -LRB- cord-015021-pol2qm74 7365 45 Clinical Clinical NNP cord-015021-pol2qm74 7365 46 Research.41:240 Research.41:240 NNPS cord-015021-pol2qm74 7365 47 , , , cord-015021-pol2qm74 7365 48 1993 1993 CD cord-015021-pol2qm74 7365 49 ) ) -RRB- cord-015021-pol2qm74 7365 50 . . . cord-015021-pol2qm74 7366 1 Methods method NNS cord-015021-pol2qm74 7366 2 : : : cord-015021-pol2qm74 7366 3 Awake awake JJ cord-015021-pol2qm74 7366 4 2 2 CD cord-015021-pol2qm74 7366 5 ylo ylo NNP cord-015021-pol2qm74 7366 6 beagles beagle NNS cord-015021-pol2qm74 7366 7 had have VBD cord-015021-pol2qm74 7366 8 serial serial JJ cord-015021-pol2qm74 7366 9 cardiopulmonary cardiopulmonary JJ cord-015021-pol2qm74 7366 10 and and CC cord-015021-pol2qm74 7366 11 laboratory laboratory NN cord-015021-pol2qm74 7366 12 studies study NNS cord-015021-pol2qm74 7366 13 before before IN cord-015021-pol2qm74 7366 14 and and CC cord-015021-pol2qm74 7366 15 for for IN cord-015021-pol2qm74 7366 16 up up IN cord-015021-pol2qm74 7366 17 to to TO cord-015021-pol2qm74 7366 18 10 10 CD cord-015021-pol2qm74 7366 19 days day NNS cord-015021-pol2qm74 7366 20 after after IN cord-015021-pol2qm74 7366 21 intraperitoneal intraperitoneal JJ cord-015021-pol2qm74 7366 22 placement placement NN cord-015021-pol2qm74 7366 23 of of IN cord-015021-pol2qm74 7366 24 an an DT cord-015021-pol2qm74 7366 25 E. E. NNP cord-015021-pol2qm74 7366 26 celi celi NNS cord-015021-pol2qm74 7366 27 infected infected JJ cord-015021-pol2qm74 7366 28 clot clot NN cord-015021-pol2qm74 7366 29 . . . cord-015021-pol2qm74 7367 1 Nine nine CD cord-015021-pol2qm74 7367 2 days day NNS cord-015021-pol2qm74 7367 3 before before IN cord-015021-pol2qm74 7367 4 and and CC cord-015021-pol2qm74 7367 5 daily daily RB cord-015021-pol2qm74 7367 6 until until IN cord-015021-pol2qm74 7367 7 3 3 CD cord-015021-pol2qm74 7367 8 days day NNS cord-015021-pol2qm74 7367 9 after after IN cord-015021-pol2qm74 7367 10 clot clot NN cord-015021-pol2qm74 7367 11 placement placement NN cord-015021-pol2qm74 7367 12 , , , cord-015021-pol2qm74 7367 13 animals animal NNS cord-015021-pol2qm74 7367 14 received receive VBD cord-015021-pol2qm74 7367 15 high high JJ cord-015021-pol2qm74 7367 16 ( ( -LRB- cord-015021-pol2qm74 7367 17 n=17 n=17 NNP cord-015021-pol2qm74 7367 18 ) ) -RRB- cord-015021-pol2qm74 7367 19 or or CC cord-015021-pol2qm74 7367 20 low low JJ cord-015021-pol2qm74 7367 21 dose dose NN cord-015021-pol2qm74 7367 22 ( ( -LRB- cord-015021-pol2qm74 7367 23 n=17 n=17 NN cord-015021-pol2qm74 7367 24 ) ) -RRB- cord-015021-pol2qm74 7367 25 G G NNP cord-015021-pol2qm74 7367 26 - - HYPH cord-015021-pol2qm74 7367 27 CSF csf NN cord-015021-pol2qm74 7367 28 or or CC cord-015021-pol2qm74 7367 29 protein protein NN cord-015021-pol2qm74 7367 30 control control NN cord-015021-pol2qm74 7367 31 ( ( -LRB- cord-015021-pol2qm74 7367 32 n=20 n=20 NNP cord-015021-pol2qm74 7367 33 ) ) -RRB- cord-015021-pol2qm74 7367 34 subcutaneously subcutaneously RB cord-015021-pol2qm74 7367 35 . . . cord-015021-pol2qm74 7368 1 Results result NNS cord-015021-pol2qm74 7368 2 : : : cord-015021-pol2qm74 7369 1 Survival survival NN cord-015021-pol2qm74 7369 2 in in IN cord-015021-pol2qm74 7369 3 high high JJ cord-015021-pol2qm74 7369 4 dose dose NN cord-015021-pol2qm74 7369 5 G G NNP cord-015021-pol2qm74 7369 6 - - HYPH cord-015021-pol2qm74 7369 7 CSF csf NN cord-015021-pol2qm74 7369 8 animals animal NNS cord-015021-pol2qm74 7369 9 ( ( -LRB- cord-015021-pol2qm74 7369 10 14/17 14/17 CD cord-015021-pol2qm74 7369 11 ) ) -RRB- cord-015021-pol2qm74 7369 12 was be VBD cord-015021-pol2qm74 7369 13 significantly significantly RB cord-015021-pol2qm74 7369 14 improved improve VBN cord-015021-pol2qm74 7369 15 compared compare VBN cord-015021-pol2qm74 7369 16 to to IN cord-015021-pol2qm74 7369 17 low low JJ cord-015021-pol2qm74 7369 18 dose dose NN cord-015021-pol2qm74 7369 19 ( ( -LRB- cord-015021-pol2qm74 7369 20 10117 10117 CD cord-015021-pol2qm74 7369 21 ) ) -RRB- cord-015021-pol2qm74 7369 22 and and CC cord-015021-pol2qm74 7369 23 controls control NNS cord-015021-pol2qm74 7369 24 ( ( -LRB- cord-015021-pol2qm74 7369 25 12120 12120 CD cord-015021-pol2qm74 7369 26 ) ) -RRB- cord-015021-pol2qm74 7369 27 ( ( -LRB- cord-015021-pol2qm74 7369 28 p<0.04 p<0.04 CD cord-015021-pol2qm74 7369 29 Wilcoxon Wilcoxon NNP cord-015021-pol2qm74 7369 30 ) ) -RRB- cord-015021-pol2qm74 7369 31 . . . cord-015021-pol2qm74 7370 1 High high JJ cord-015021-pol2qm74 7370 2 dose dose NN cord-015021-pol2qm74 7370 3 G G NNP cord-015021-pol2qm74 7370 4 - - HYPH cord-015021-pol2qm74 7370 5 CSF CSF NNP cord-015021-pol2qm74 7370 6 also also RB cord-015021-pol2qm74 7370 7 improved improve VBD cord-015021-pol2qm74 7370 8 cardiovascular cardiovascular JJ cord-015021-pol2qm74 7370 9 function function NN cord-015021-pol2qm74 7370 10 evidenced evidence VBN cord-015021-pol2qm74 7370 11 by by IN cord-015021-pol2qm74 7370 12 a a DT cord-015021-pol2qm74 7370 13 higher high JJR cord-015021-pol2qm74 7370 14 mean mean NN cord-015021-pol2qm74 7370 15 left leave VBN cord-015021-pol2qm74 7370 16 ventricular ventricular JJ cord-015021-pol2qm74 7370 17 ejection ejection NN cord-015021-pol2qm74 7370 18 fraction fraction NN cord-015021-pol2qm74 7370 19 ( ( -LRB- cord-015021-pol2qm74 7370 20 day day NN cord-015021-pol2qm74 7370 21 1 1 CD cord-015021-pol2qm74 7370 22 after after IN cord-015021-pol2qm74 7370 23 clot clot NN cord-015021-pol2qm74 7370 24 , , , cord-015021-pol2qm74 7370 25 p<0.001 p<0.001 CD cord-015021-pol2qm74 7370 26 ) ) -RRB- cord-015021-pol2qm74 7370 27 and and CC cord-015021-pol2qm74 7370 28 mean mean VB cord-015021-pol2qm74 7370 29 arterial arterial JJ cord-015021-pol2qm74 7370 30 pressure pressure NN cord-015021-pol2qm74 7370 31 ( ( -LRB- cord-015021-pol2qm74 7370 32 day day NN cord-015021-pol2qm74 7370 33 2 2 CD cord-015021-pol2qm74 7370 34 , , , cord-015021-pol2qm74 7370 35 p<0,02 p<0,02 NNP cord-015021-pol2qm74 7370 36 ) ) -RRB- cord-015021-pol2qm74 7370 37 compared compare VBN cord-015021-pol2qm74 7370 38 to to IN cord-015021-pol2qm74 7370 39 low low JJ cord-015021-pol2qm74 7370 40 dose dose NN cord-015021-pol2qm74 7370 41 and and CC cord-015021-pol2qm74 7370 42 controls control NNS cord-015021-pol2qm74 7370 43 . . . cord-015021-pol2qm74 7371 1 High high JJ cord-015021-pol2qm74 7371 2 dose dose NN cord-015021-pol2qm74 7371 3 rcG rcG NNP cord-015021-pol2qm74 7371 4 - - HYPH cord-015021-pol2qm74 7371 5 CSF csf NN cord-015021-pol2qm74 7371 6 increased increase VBD cord-015021-pol2qm74 7371 7 ( ( -LRB- cord-015021-pol2qm74 7371 8 p<0.001 p<0.001 JJ cord-015021-pol2qm74 7371 9 ) ) -RRB- cord-015021-pol2qm74 7371 10 peripheral peripheral JJ cord-015021-pol2qm74 7371 11 neutrophil neutrophil NN cord-015021-pol2qm74 7371 12 numbers number NNS cord-015021-pol2qm74 7371 13 both both CC cord-015021-pol2qm74 7371 14 before before IN cord-015021-pol2qm74 7371 15 and and CC cord-015021-pol2qm74 7371 16 after after IN cord-015021-pol2qm74 7371 17 clot clot NN cord-015021-pol2qm74 7371 18 implantation implantation NN cord-015021-pol2qm74 7371 19 ( ( -LRB- cord-015021-pol2qm74 7371 20 2 2 CD cord-015021-pol2qm74 7371 21 hours hour NNS cord-015021-pol2qm74 7371 22 to to IN cord-015021-pol2qm74 7371 23 4 4 CD cord-015021-pol2qm74 7371 24 days day NNS cord-015021-pol2qm74 7371 25 ) ) -RRB- cord-015021-pol2qm74 7371 26 compared compare VBN cord-015021-pol2qm74 7371 27 to to IN cord-015021-pol2qm74 7371 28 low low JJ cord-015021-pol2qm74 7371 29 dose dose NN cord-015021-pol2qm74 7371 30 and and CC cord-015021-pol2qm74 7371 31 controls control NNS cord-015021-pol2qm74 7371 32 . . . cord-015021-pol2qm74 7372 1 In in IN cord-015021-pol2qm74 7372 2 addition addition NN cord-015021-pol2qm74 7372 3 , , , cord-015021-pol2qm74 7372 4 high high JJ cord-015021-pol2qm74 7372 5 dose dose NN cord-015021-pol2qm74 7372 6 rcG rcG NNP cord-015021-pol2qm74 7372 7 - - HYPH cord-015021-pol2qm74 7372 8 CSF CSF NNP cord-015021-pol2qm74 7372 9 produced produce VBD cord-015021-pol2qm74 7372 10 a a DT cord-015021-pol2qm74 7372 11 more more RBR cord-015021-pol2qm74 7372 12 rapid rapid JJ cord-015021-pol2qm74 7372 13 ( ( -LRB- cord-015021-pol2qm74 7372 14 p<0.0001 p<0.0001 NNP cord-015021-pol2qm74 7372 15 ) ) -RRB- cord-015021-pol2qm74 7372 16 rise rise NN cord-015021-pol2qm74 7372 17 ( ( -LRB- cord-015021-pol2qm74 7372 18 day day NN cord-015021-pol2qm74 7372 19 2 2 CD cord-015021-pol2qm74 7372 20 ) ) -RRB- cord-015021-pol2qm74 7372 21 and and CC cord-015021-pol2qm74 7372 22 fall fall VB cord-015021-pol2qm74 7372 23 ( ( -LRB- cord-015021-pol2qm74 7372 24 day day NN cord-015021-pol2qm74 7372 25 4 4 CD cord-015021-pol2qm74 7372 26 ) ) -RRB- cord-015021-pol2qm74 7372 27 in in IN cord-015021-pol2qm74 7372 28 alveolar alveolar JJ cord-015021-pol2qm74 7372 29 neutrophils neutrophil NNS cord-015021-pol2qm74 7372 30 determined determine VBN cord-015021-pol2qm74 7372 31 by by IN cord-015021-pol2qm74 7372 32 bronchoalveolar bronchoalveolar NNP cord-015021-pol2qm74 7372 33 lavage lavage NN cord-015021-pol2qm74 7372 34 compared compare VBN cord-015021-pol2qm74 7372 35 to to IN cord-015021-pol2qm74 7372 36 low low JJ cord-015021-pol2qm74 7372 37 dose dose NN cord-015021-pol2qm74 7372 38 and and CC cord-015021-pol2qm74 7372 39 controls control NNS cord-015021-pol2qm74 7372 40 . . . cord-015021-pol2qm74 7373 1 Lastly lastly RB cord-015021-pol2qm74 7373 2 , , , cord-015021-pol2qm74 7373 3 high high JJ cord-015021-pol2qm74 7373 4 dose dose NN cord-015021-pol2qm74 7373 5 rcG rcG NNP cord-015021-pol2qm74 7373 6 - - HYPH cord-015021-pol2qm74 7373 7 CSF csf NN cord-015021-pol2qm74 7373 8 decreased decrease VBD cord-015021-pol2qm74 7373 9 serum serum NN cord-015021-pol2qm74 7373 10 endotoxin endotoxin NN cord-015021-pol2qm74 7373 11 ( ( -LRB- cord-015021-pol2qm74 7373 12 2 2 CD cord-015021-pol2qm74 7373 13 to to IN cord-015021-pol2qm74 7373 14 8h 8h NNP cord-015021-pol2qm74 7373 15 , , , cord-015021-pol2qm74 7373 16 p<0.002 p<0.002 CD cord-015021-pol2qm74 7373 17 ) ) -RRB- cord-015021-pol2qm74 7373 18 and and CC cord-015021-pol2qm74 7373 19 tumor tumor NN cord-015021-pol2qm74 7373 20 necrosis necrosis NN cord-015021-pol2qm74 7373 21 factor factor NN cord-015021-pol2qm74 7373 22 ( ( -LRB- cord-015021-pol2qm74 7373 23 TNF TNF NNP cord-015021-pol2qm74 7373 24 , , , cord-015021-pol2qm74 7373 25 2h 2h CD cord-015021-pol2qm74 7373 26 , , , cord-015021-pol2qm74 7373 27 p<0.02 p<0.02 NN cord-015021-pol2qm74 7373 28 ) ) -RRB- cord-015021-pol2qm74 7373 29 levels level NNS cord-015021-pol2qm74 7373 30 compared compare VBN cord-015021-pol2qm74 7373 31 to to IN cord-015021-pol2qm74 7373 32 low low JJ cord-015021-pol2qm74 7373 33 dose dose NN cord-015021-pol2qm74 7373 34 and and CC cord-015021-pol2qm74 7373 35 controls control NNS cord-015021-pol2qm74 7373 36 . . . cord-015021-pol2qm74 7374 1 Discussion discussion NN cord-015021-pol2qm74 7374 2 : : : cord-015021-pol2qm74 7375 1 These these DT cord-015021-pol2qm74 7375 2 data datum NNS cord-015021-pol2qm74 7375 3 suggest suggest VBP cord-015021-pol2qm74 7375 4 that that IN cord-015021-pol2qm74 7375 5 therapy therapy NN cord-015021-pol2qm74 7375 6 with with IN cord-015021-pol2qm74 7375 7 G G NNP cord-015021-pol2qm74 7375 8 - - HYPH cord-015021-pol2qm74 7375 9 CSF CSF NNP cord-015021-pol2qm74 7375 10 sufficient sufficient JJ cord-015021-pol2qm74 7375 11 to to TO cord-015021-pol2qm74 7375 12 increase increase VB cord-015021-pol2qm74 7375 13 peripheral peripheral JJ cord-015021-pol2qm74 7375 14 neutrophil neutrophil NN cord-015021-pol2qm74 7375 15 numbers number NNS cord-015021-pol2qm74 7375 16 during during IN cord-015021-pol2qm74 7375 17 peritonitis peritonitis NN cord-015021-pol2qm74 7375 18 and and CC cord-015021-pol2qm74 7375 19 septic septic JJ cord-015021-pol2qm74 7375 20 shock shock NN cord-015021-pol2qm74 7375 21 may may MD cord-015021-pol2qm74 7375 22 augment augment VB cord-015021-pol2qm74 7375 23 host host NN cord-015021-pol2qm74 7375 24 defense defense NN cord-015021-pol2qm74 7375 25 and and CC cord-015021-pol2qm74 7375 26 endotoxin endotoxin NN cord-015021-pol2qm74 7375 27 clearance clearance NN cord-015021-pol2qm74 7375 28 , , , cord-015021-pol2qm74 7375 29 reduce reduce VB cord-015021-pol2qm74 7375 30 cytokine cytokine NN cord-015021-pol2qm74 7375 31 levels level NNS cord-015021-pol2qm74 7375 32 ( ( -LRB- cord-015021-pol2qm74 7375 33 TNF TNF NNP cord-015021-pol2qm74 7375 34 ) ) -RRB- cord-015021-pol2qm74 7375 35 and and CC cord-015021-pol2qm74 7375 36 improve improve VB cord-015021-pol2qm74 7375 37 cardiovascular cardiovascular JJ cord-015021-pol2qm74 7375 38 function function NN cord-015021-pol2qm74 7375 39 and and CC cord-015021-pol2qm74 7375 40 survival survival NN cord-015021-pol2qm74 7375 41 . . . cord-015021-pol2qm74 7376 1 The the DT cord-015021-pol2qm74 7376 2 use use NN cord-015021-pol2qm74 7376 3 of of IN cord-015021-pol2qm74 7376 4 G G NNP cord-015021-pol2qm74 7376 5 - - HYPH cord-015021-pol2qm74 7376 6 CSF CSF NNP cord-015021-pol2qm74 7376 7 in in IN cord-015021-pol2qm74 7376 8 sepsis sepsis NN cord-015021-pol2qm74 7376 9 prophylaxis prophylaxis NN cord-015021-pol2qm74 7376 10 in in IN cord-015021-pol2qm74 7376 11 neutropenic neutropenic JJ cord-015021-pol2qm74 7376 12 patients patient NNS cord-015021-pol2qm74 7376 13 is be VBZ cord-015021-pol2qm74 7376 14 well well RB cord-015021-pol2qm74 7376 15 established establish VBN cord-015021-pol2qm74 7376 16 and and CC cord-015021-pol2qm74 7376 17 has have VBZ cord-015021-pol2qm74 7376 18 been be VBN cord-015021-pol2qm74 7376 19 ascribed ascribe VBN cord-015021-pol2qm74 7376 20 to to IN cord-015021-pol2qm74 7376 21 accelerated accelerate VBN cord-015021-pol2qm74 7376 22 recovery recovery NN cord-015021-pol2qm74 7376 23 in in IN cord-015021-pol2qm74 7376 24 granulccyte granulccyte NNP cord-015021-pol2qm74 7376 25 counts count VBZ cord-015021-pol2qm74 7376 26 . . . cord-015021-pol2qm74 7377 1 Here here RB cord-015021-pol2qm74 7377 2 , , , cord-015021-pol2qm74 7377 3 an an DT cord-015021-pol2qm74 7377 4 additional additional JJ cord-015021-pol2qm74 7377 5 sepsis sepsis NN cord-015021-pol2qm74 7377 6 - - HYPH cord-015021-pol2qm74 7377 7 prophylactic prophylactic JJ cord-015021-pol2qm74 7377 8 property property NN cord-015021-pol2qm74 7377 9 could could MD cord-015021-pol2qm74 7377 10 be be VB cord-015021-pol2qm74 7377 11 demonstrated demonstrate VBN cord-015021-pol2qm74 7377 12 in in IN cord-015021-pol2qm74 7377 13 healthy healthy JJ cord-015021-pol2qm74 7377 14 volunteers volunteer NNS cord-015021-pol2qm74 7377 15 : : : cord-015021-pol2qm74 7377 16 Eleven eleven CD cord-015021-pol2qm74 7377 17 volunteers volunteer NNS cord-015021-pol2qm74 7377 18 were be VBD cord-015021-pol2qm74 7377 19 employed employ VBN cord-015021-pol2qm74 7377 20 in in IN cord-015021-pol2qm74 7377 21 a a DT cord-015021-pol2qm74 7377 22 sinqle sinqle NNP cord-015021-pol2qm74 7377 23 - - HYPH cord-015021-pol2qm74 7377 24 bTind bTind NNP cord-015021-pol2qm74 7377 25 , , , cord-015021-pol2qm74 7377 26 controlled controlled JJ cord-015021-pol2qm74 7377 27 study study NN cord-015021-pol2qm74 7377 28 and and CC cord-015021-pol2qm74 7377 29 were be VBD cord-015021-pol2qm74 7377 30 given give VBN cord-015021-pol2qm74 7377 31 480 480 CD cord-015021-pol2qm74 7377 32 uq uq NNP cord-015021-pol2qm74 7377 33 G G NNP cord-015021-pol2qm74 7377 34 - - HYPH cord-015021-pol2qm74 7377 35 CSF CSF NNP cord-015021-pol2qm74 7377 36 or or CC cord-015021-pol2qm74 7377 37 saline saline NN cord-015021-pol2qm74 7377 38 placebo placebo NN cord-015021-pol2qm74 7377 39 via via IN cord-015021-pol2qm74 7377 40 subcutaneous subcutaneous JJ cord-015021-pol2qm74 7377 41 injection injection NN cord-015021-pol2qm74 7377 42 . . . cord-015021-pol2qm74 7378 1 Blood blood NN cord-015021-pol2qm74 7378 2 was be VBD cord-015021-pol2qm74 7378 3 withdrawn withdraw VBN cord-015021-pol2qm74 7378 4 immediately immediately RB cord-015021-pol2qm74 7378 5 before before RB cord-015021-pol2qm74 7378 6 and and CC cord-015021-pol2qm74 7378 7 20 20 CD cord-015021-pol2qm74 7378 8 or or CC cord-015021-pol2qm74 7378 9 44 44 CD cord-015021-pol2qm74 7378 10 hours hour NNS cord-015021-pol2qm74 7378 11 later later RB cord-015021-pol2qm74 7378 12 . . . cord-015021-pol2qm74 7379 1 LPS LPS NNP cord-015021-pol2qm74 7379 2 - - HYPH cord-015021-pol2qm74 7379 3 inducible inducible JJ cord-015021-pol2qm74 7379 4 TNF TNF NNP cord-015021-pol2qm74 7379 5 , , , cord-015021-pol2qm74 7379 6 IL-1 IL-1 NNP cord-015021-pol2qm74 7379 7 , , , cord-015021-pol2qm74 7379 8 sTNF stnf NN cord-015021-pol2qm74 7379 9 - - HYPH cord-015021-pol2qm74 7379 10 R r JJ cord-015021-pol2qm74 7379 11 p75 p75 NN cord-015021-pol2qm74 7379 12 and and CC cord-015021-pol2qm74 7379 13 IL IL NNP cord-015021-pol2qm74 7379 14 - - HYPH cord-015021-pol2qm74 7379 15 lra lra NNP cord-015021-pol2qm74 7379 16 were be VBD cord-015021-pol2qm74 7379 17 assessed assess VBN cord-015021-pol2qm74 7379 18 in in IN cord-015021-pol2qm74 7379 19 the the DT cord-015021-pol2qm74 7379 20 supernatant supernatant NN cord-015021-pol2qm74 7379 21 of of IN cord-015021-pol2qm74 7379 22 whole whole JJ cord-015021-pol2qm74 7379 23 blood blood NN cord-015021-pol2qm74 7379 24 incubations incubation NNS cord-015021-pol2qm74 7379 25 stimulated stimulate VBN cord-015021-pol2qm74 7379 26 with with IN cord-015021-pol2qm74 7379 27 10 10 CD cord-015021-pol2qm74 7379 28 ug ug NNP cord-015021-pol2qm74 7379 29 / / SYM cord-015021-pol2qm74 7379 30 ml ml NN cord-015021-pol2qm74 7379 31 LPS LPS NNP cord-015021-pol2qm74 7379 32 from from IN cord-015021-pol2qm74 7379 33 Salmonella Salmonella NNP cord-015021-pol2qm74 7379 34 abortus abortus NN cord-015021-pol2qm74 7379 35 equi equi NN cord-015021-pol2qm74 7379 36 . . . cord-015021-pol2qm74 7380 1 Similarly similarly RB cord-015021-pol2qm74 7380 2 to to IN cord-015021-pol2qm74 7380 3 previous previous JJ cord-015021-pol2qm74 7380 4 animal animal NN cord-015021-pol2qm74 7380 5 studies study NNS cord-015021-pol2qm74 7380 6 , , , cord-015021-pol2qm74 7380 7 LPS LPS NNP cord-015021-pol2qm74 7380 8 - - HYPH cord-015021-pol2qm74 7380 9 inducible inducible JJ cord-015021-pol2qm74 7380 10 TNF TNF NNP cord-015021-pol2qm74 7380 11 was be VBD cord-015021-pol2qm74 7380 12 attenuated attenuate VBN cord-015021-pol2qm74 7380 13 by by IN cord-015021-pol2qm74 7380 14 about about RB cord-015021-pol2qm74 7380 15 50 50 CD cord-015021-pol2qm74 7380 16 % % NN cord-015021-pol2qm74 7380 17 20 20 CD cord-015021-pol2qm74 7380 18 hrs hrs NN cord-015021-pol2qm74 7380 19 . . . cord-015021-pol2qm74 7381 1 after after IN cord-015021-pol2qm74 7381 2 treatment treatment NN cord-015021-pol2qm74 7381 3 . . . cord-015021-pol2qm74 7382 1 The the DT cord-015021-pol2qm74 7382 2 same same JJ cord-015021-pol2qm74 7382 3 was be VBD cord-015021-pol2qm74 7382 4 true true JJ cord-015021-pol2qm74 7382 5 of of IN cord-015021-pol2qm74 7382 6 IL IL NNP cord-015021-pol2qm74 7382 7 - - HYPH cord-015021-pol2qm74 7382 8 lb lb NN cord-015021-pol2qm74 7382 9 . . . cord-015021-pol2qm74 7383 1 In in IN cord-015021-pol2qm74 7383 2 contrast contrast NN cord-015021-pol2qm74 7383 3 , , , cord-015021-pol2qm74 7383 4 LPS LPS NNP cord-015021-pol2qm74 7383 5 - - HYPH cord-015021-pol2qm74 7383 6 inducible inducible JJ cord-015021-pol2qm74 7383 7 sTNF stnf NN cord-015021-pol2qm74 7383 8 - - HYPH cord-015021-pol2qm74 7383 9 R r NN cord-015021-pol2qm74 7383 10 p75 p75 NN cord-015021-pol2qm74 7383 11 which which WDT cord-015021-pol2qm74 7383 12 was be VBD cord-015021-pol2qm74 7383 13 indetectable indetectable JJ cord-015021-pol2qm74 7383 14 in in IN cord-015021-pol2qm74 7383 15 blood blood NN cord-015021-pol2qm74 7383 16 incubations incubation NNS cord-015021-pol2qm74 7383 17 from from IN cord-015021-pol2qm74 7383 18 untreated untreated JJ cord-015021-pol2qm74 7383 19 donors donor NNS cord-015021-pol2qm74 7383 20 increased increase VBD cord-015021-pol2qm74 7383 21 dramatically dramatically RB cord-015021-pol2qm74 7383 22 44 44 CD cord-015021-pol2qm74 7383 23 hrs hrs NN cord-015021-pol2qm74 7383 24 . . . cord-015021-pol2qm74 7384 1 after after IN cord-015021-pol2qm74 7384 2 G G NNP cord-015021-pol2qm74 7384 3 - - HYPH cord-015021-pol2qm74 7384 4 CSF csf NN cord-015021-pol2qm74 7384 5 treatment treatment NN cord-015021-pol2qm74 7384 6 . . . cord-015021-pol2qm74 7385 1 IL IL NNP cord-015021-pol2qm74 7385 2 - - HYPH cord-015021-pol2qm74 7385 3 lra lra NNP cord-015021-pol2qm74 7385 4 found find VBD cord-015021-pol2qm74 7385 5 after after IN cord-015021-pol2qm74 7385 6 LPS LPS NNP cord-015021-pol2qm74 7385 7 challenge challenge NN cord-015021-pol2qm74 7385 8 was be VBD cord-015021-pol2qm74 7385 9 increased increase VBN cord-015021-pol2qm74 7385 10 tenfold tenfold RB cord-015021-pol2qm74 7385 11 by by IN cord-015021-pol2qm74 7385 12 G G NNP cord-015021-pol2qm74 7385 13 - - HYPH cord-015021-pol2qm74 7385 14 CSF CSF NNP cord-015021-pol2qm74 7385 15 treatment treatment NN cord-015021-pol2qm74 7385 16 . . . cord-015021-pol2qm74 7386 1 It -PRON- PRP cord-015021-pol2qm74 7386 2 is be VBZ cord-015021-pol2qm74 7386 3 concluded conclude VBN cord-015021-pol2qm74 7386 4 that that IN cord-015021-pol2qm74 7386 5 G G NNP cord-015021-pol2qm74 7386 6 - - HYPH cord-015021-pol2qm74 7386 7 CSF CSF NNP cord-015021-pol2qm74 7386 8 treatment treatment NN cord-015021-pol2qm74 7386 9 switches switch VBZ cord-015021-pol2qm74 7386 10 peripheral peripheral JJ cord-015021-pol2qm74 7386 11 leukocytes leukocyte NNS cord-015021-pol2qm74 7386 12 to to IN cord-015021-pol2qm74 7386 13 an an DT cord-015021-pol2qm74 7386 14 antiinflammatery antiinflammatery JJ cord-015021-pol2qm74 7386 15 state state NN cord-015021-pol2qm74 7386 16 characterized characterize VBN cord-015021-pol2qm74 7386 17 by by IN cord-015021-pol2qm74 7386 18 an an DT cord-015021-pol2qm74 7386 19 attenuation attenuation NN cord-015021-pol2qm74 7386 20 of of IN cord-015021-pol2qm74 7386 21 IL IL NNP cord-015021-pol2qm74 7386 22 - - : cord-015021-pol2qm74 7386 23 I I NNP cord-015021-pol2qm74 7386 24 and and CC cord-015021-pol2qm74 7386 25 TNF TNF NNP cord-015021-pol2qm74 7386 26 releasing release VBG cord-015021-pol2qm74 7386 27 capacity capacity NN cord-015021-pol2qm74 7386 28 and and CC cord-015021-pol2qm74 7386 29 an an DT cord-015021-pol2qm74 7386 30 augmentation augmentation NN cord-015021-pol2qm74 7386 31 of of IN cord-015021-pol2qm74 7386 32 the the DT cord-015021-pol2qm74 7386 33 release release NN cord-015021-pol2qm74 7386 34 of of IN cord-015021-pol2qm74 7386 35 cytokine cytokine JJ cord-015021-pol2qm74 7386 36 antagonists antagonist NNS cord-015021-pol2qm74 7386 37 . . . cord-015021-pol2qm74 7387 1 This this DT cord-015021-pol2qm74 7387 2 findinq findinq NNP cord-015021-pol2qm74 7387 3 minht minht NNP cord-015021-pol2qm74 7387 4 offer offer VBP cord-015021-pol2qm74 7387 5 a a DT cord-015021-pol2qm74 7387 6 novel novel JJ cord-015021-pol2qm74 7387 7 concept concept NN cord-015021-pol2qm74 7387 8 in in IN cord-015021-pol2qm74 7387 9 septic septic JJ cord-015021-pol2qm74 7387 10 shock shock NN cord-015021-pol2qm74 7387 11 prophylaxis prophylaxis NN cord-015021-pol2qm74 7387 12 . . . cord-015021-pol2qm74 7388 1 Objective objective JJ cord-015021-pol2qm74 7388 2 . . . cord-015021-pol2qm74 7389 1 The the DT cord-015021-pol2qm74 7389 2 aim aim NN cord-015021-pol2qm74 7389 3 of of IN cord-015021-pol2qm74 7389 4 the the DT cord-015021-pol2qm74 7389 5 study study NN cord-015021-pol2qm74 7389 6 was be VBD cord-015021-pol2qm74 7389 7 to to TO cord-015021-pol2qm74 7389 8 investigate investigate VB cord-015021-pol2qm74 7389 9 the the DT cord-015021-pol2qm74 7389 10 effect effect NN cord-015021-pol2qm74 7389 11 of of IN cord-015021-pol2qm74 7389 12 recombinant recombinant JJ cord-015021-pol2qm74 7389 13 human human JJ cord-015021-pol2qm74 7389 14 G G NNP cord-015021-pol2qm74 7389 15 - - HYPH cord-015021-pol2qm74 7389 16 CSF CSF NNP cord-015021-pol2qm74 7389 17 ( ( -LRB- cord-015021-pol2qm74 7389 18 rhG rhG NNP cord-015021-pol2qm74 7389 19 - - HYPH cord-015021-pol2qm74 7389 20 CSF CSF NNP cord-015021-pol2qm74 7389 21 ) ) -RRB- cord-015021-pol2qm74 7389 22 on on IN cord-015021-pol2qm74 7389 23 survival survival NN cord-015021-pol2qm74 7389 24 , , , cord-015021-pol2qm74 7389 25 bone bone NN cord-015021-pol2qm74 7389 26 marrow marrow NN cord-015021-pol2qm74 7389 27 neutrophil neutrophil NN cord-015021-pol2qm74 7389 28 myelopoiesis myelopoiesis NN cord-015021-pol2qm74 7389 29 , , , cord-015021-pol2qm74 7389 30 neutrophil neutrophil NN cord-015021-pol2qm74 7389 31 counts count NNS cord-015021-pol2qm74 7389 32 , , , cord-015021-pol2qm74 7389 33 levels level NNS cord-015021-pol2qm74 7389 34 of of IN cord-015021-pol2qm74 7389 35 bacteria bacteria NNS cord-015021-pol2qm74 7389 36 and and CC cord-015021-pol2qm74 7389 37 some some DT cord-015021-pol2qm74 7389 38 important important JJ cord-015021-pol2qm74 7389 39 sepsis sepsis NN cord-015021-pol2qm74 7389 40 mediators mediator NNS cord-015021-pol2qm74 7389 41 in in IN cord-015021-pol2qm74 7389 42 a a DT cord-015021-pol2qm74 7389 43 model model NN cord-015021-pol2qm74 7389 44 of of IN cord-015021-pol2qm74 7389 45 rat rat NN cord-015021-pol2qm74 7389 46 abdominal abdominal JJ cord-015021-pol2qm74 7389 47 sepsis sepsis NN cord-015021-pol2qm74 7389 48 . . . cord-015021-pol2qm74 7390 1 Lethal lethal JJ cord-015021-pol2qm74 7390 2 peritonitis peritonitis NN cord-015021-pol2qm74 7390 3 was be VBD cord-015021-pol2qm74 7390 4 induced induce VBN cord-015021-pol2qm74 7390 5 with with IN cord-015021-pol2qm74 7390 6 a a DT cord-015021-pol2qm74 7390 7 4 4 CD cord-015021-pol2qm74 7390 8 mm mm NN cord-015021-pol2qm74 7390 9 coecal coecal JJ cord-015021-pol2qm74 7390 10 perforation perforation NN cord-015021-pol2qm74 7390 11 ( ( -LRB- cord-015021-pol2qm74 7390 12 CP CP NNP cord-015021-pol2qm74 7390 13 ) ) -RRB- cord-015021-pol2qm74 7390 14 in in IN cord-015021-pol2qm74 7390 15 male male JJ cord-015021-pol2qm74 7390 16 Wistar Wistar NNP cord-015021-pol2qm74 7390 17 rats rat NNS cord-015021-pol2qm74 7390 18 . . . cord-015021-pol2qm74 7391 1 rhG rhG NNP cord-015021-pol2qm74 7391 2 - - HYPH cord-015021-pol2qm74 7391 3 CSF CSF NNP cord-015021-pol2qm74 7391 4 was be VBD cord-015021-pol2qm74 7391 5 administered administer VBN cord-015021-pol2qm74 7391 6 as as IN cord-015021-pol2qm74 7391 7 10 10 CD cord-015021-pol2qm74 7391 8 /.tg /.tg . cord-015021-pol2qm74 7392 1 /kg /kg . cord-015021-pol2qm74 7393 1 iv iv LS cord-015021-pol2qm74 7394 1 every every DT cord-015021-pol2qm74 7394 2 12 12 CD cord-015021-pol2qm74 7394 3 h h NN cord-015021-pol2qm74 7394 4 , , , cord-015021-pol2qm74 7394 5 first first JJ cord-015021-pol2qm74 7394 6 dose dose NN cord-015021-pol2qm74 7394 7 at at IN cord-015021-pol2qm74 7394 8 sepsis sepsis NN cord-015021-pol2qm74 7394 9 induction induction NN cord-015021-pol2qm74 7394 10 . . . cord-015021-pol2qm74 7395 1 Bone bone NN cord-015021-pol2qm74 7395 2 marrow marrow NN cord-015021-pol2qm74 7395 3 neutrophi neutrophi NNP cord-015021-pol2qm74 7395 4 ] ] -RRB- cord-015021-pol2qm74 7395 5 progenitors progenitor NNS cord-015021-pol2qm74 7395 6 were be VBD cord-015021-pol2qm74 7395 7 determined determine VBN cord-015021-pol2qm74 7395 8 as as IN cord-015021-pol2qm74 7395 9 blast blast NN cord-015021-pol2qm74 7395 10 colonies colony NNS cord-015021-pol2qm74 7395 11 , , , cord-015021-pol2qm74 7395 12 CFU CFU NNP cord-015021-pol2qm74 7395 13 - - HYPH cord-015021-pol2qm74 7395 14 GM GM NNP cord-015021-pol2qm74 7395 15 and and CC cord-015021-pol2qm74 7395 16 CFU CFU NNP cord-015021-pol2qm74 7395 17 - - HYPH cord-015021-pol2qm74 7395 18 G. G. NNP cord-015021-pol2qm74 7395 19 Neutrophils Neutrophils NNPS cord-015021-pol2qm74 7395 20 and and CC cord-015021-pol2qm74 7395 21 bacteria bacteria NNS cord-015021-pol2qm74 7395 22 were be VBD cord-015021-pol2qm74 7395 23 determined determine VBN cord-015021-pol2qm74 7395 24 in in IN cord-015021-pol2qm74 7395 25 peripheral peripheral JJ cord-015021-pol2qm74 7395 26 blood blood NN cord-015021-pol2qm74 7395 27 and and CC cord-015021-pol2qm74 7395 28 peritoneal peritoneal JJ cord-015021-pol2qm74 7395 29 fluid fluid NN cord-015021-pol2qm74 7395 30 . . . cord-015021-pol2qm74 7396 1 LPS LPS NNP cord-015021-pol2qm74 7396 2 , , , cord-015021-pol2qm74 7396 3 TNF TNF NNP cord-015021-pol2qm74 7396 4 , , , cord-015021-pol2qm74 7396 5 Endothelin Endothelin NNP cord-015021-pol2qm74 7396 6 21 21 CD cord-015021-pol2qm74 7396 7 and and CC cord-015021-pol2qm74 7396 8 Lactate Lactate NNP cord-015021-pol2qm74 7396 9 were be VBD cord-015021-pol2qm74 7396 10 measured measure VBN cord-015021-pol2qm74 7396 11 in in IN cord-015021-pol2qm74 7396 12 blood blood NN cord-015021-pol2qm74 7396 13 from from IN cord-015021-pol2qm74 7396 14 femoral femoral JJ cord-015021-pol2qm74 7396 15 vein vein NN cord-015021-pol2qm74 7396 16 . . . cord-015021-pol2qm74 7397 1 Mortality mortality NN cord-015021-pol2qm74 7397 2 rates rate NNS cord-015021-pol2qm74 7397 3 were be VBD cord-015021-pol2qm74 7397 4 registered register VBN cord-015021-pol2qm74 7397 5 with with IN cord-015021-pol2qm74 7397 6 G G NNP cord-015021-pol2qm74 7397 7 - - HYPH cord-015021-pol2qm74 7397 8 CSF csf NN cord-015021-pol2qm74 7397 9 treatment treatment NN cord-015021-pol2qm74 7397 10 starting start VBG cord-015021-pol2qm74 7397 11 either either CC cord-015021-pol2qm74 7397 12 1 1 CD cord-015021-pol2qm74 7397 13 or or CC cord-015021-pol2qm74 7397 14 7 7 CD cord-015021-pol2qm74 7397 15 days day NNS cord-015021-pol2qm74 7397 16 before before IN cord-015021-pol2qm74 7397 17 or or CC cord-015021-pol2qm74 7397 18 4 4 CD cord-015021-pol2qm74 7397 19 hours hour NNS cord-015021-pol2qm74 7397 20 after after IN cord-015021-pol2qm74 7397 21 CP cp NN cord-015021-pol2qm74 7397 22 . . . cord-015021-pol2qm74 7398 1 Results result NNS cord-015021-pol2qm74 7398 2 . . . cord-015021-pol2qm74 7399 1 Mortality mortality NN cord-015021-pol2qm74 7399 2 was be VBD cord-015021-pol2qm74 7399 3 reduced reduce VBN cord-015021-pol2qm74 7399 4 from from IN cord-015021-pol2qm74 7399 5 90 90 CD cord-015021-pol2qm74 7399 6 % % NN cord-015021-pol2qm74 7399 7 to to IN cord-015021-pol2qm74 7399 8 about about IN cord-015021-pol2qm74 7399 9 50 50 CD cord-015021-pol2qm74 7399 10 % % NN cord-015021-pol2qm74 7399 11 with with IN cord-015021-pol2qm74 7399 12 rhG rhG NNP cord-015021-pol2qm74 7399 13 - - HYPH cord-015021-pol2qm74 7399 14 CSF csf NN cord-015021-pol2qm74 7399 15 intervention intervention NN cord-015021-pol2qm74 7399 16 and and CC cord-015021-pol2qm74 7399 17 there there EX cord-015021-pol2qm74 7399 18 was be VBD cord-015021-pol2qm74 7399 19 no no DT cord-015021-pol2qm74 7399 20 difference difference NN cord-015021-pol2qm74 7399 21 between between IN cord-015021-pol2qm74 7399 22 the the DT cord-015021-pol2qm74 7399 23 pretreatment pretreatment NN cord-015021-pol2qm74 7399 24 and and CC cord-015021-pol2qm74 7399 25 treatment treatment NN cord-015021-pol2qm74 7399 26 groups group NNS cord-015021-pol2qm74 7399 27 . . . cord-015021-pol2qm74 7400 1 Bone bone NN cord-015021-pol2qm74 7400 2 marrow marrow NN cord-015021-pol2qm74 7400 3 blast blast NN cord-015021-pol2qm74 7400 4 colonies colony NNS cord-015021-pol2qm74 7400 5 were be VBD cord-015021-pol2qm74 7400 6 not not RB cord-015021-pol2qm74 7400 7 influenced influence VBN cord-015021-pol2qm74 7400 8 while while IN cord-015021-pol2qm74 7400 9 neutrophil neutrophil NN cord-015021-pol2qm74 7400 10 myelopoiesis myelopoiesis NNP cord-015021-pol2qm74 7400 11 was be VBD cord-015021-pol2qm74 7400 12 augmented augment VBN cord-015021-pol2qm74 7400 13 at at IN cord-015021-pol2qm74 7400 14 the the DT cord-015021-pol2qm74 7400 15 stages stage NNS cord-015021-pol2qm74 7400 16 of of IN cord-015021-pol2qm74 7400 17 CFU CFU NNP cord-015021-pol2qm74 7400 18 - - HYPH cord-015021-pol2qm74 7400 19 GM GM NNP cord-015021-pol2qm74 7400 20 and and CC cord-015021-pol2qm74 7400 21 CFU CFU NNP cord-015021-pol2qm74 7400 22 - - HYPH cord-015021-pol2qm74 7400 23 G. G. NNP cord-015021-pol2qm74 7400 24 Neutrophils Neutrophils NNPS cord-015021-pol2qm74 7400 25 in in IN cord-015021-pol2qm74 7400 26 blood blood NN cord-015021-pol2qm74 7400 27 and and CC cord-015021-pol2qm74 7400 28 peritoneal peritoneal JJ cord-015021-pol2qm74 7400 29 cavity cavity NN cord-015021-pol2qm74 7400 30 were be VBD cord-015021-pol2qm74 7400 31 enhanced enhance VBN cord-015021-pol2qm74 7400 32 and and CC cord-015021-pol2qm74 7400 33 numbers number NNS cord-015021-pol2qm74 7400 34 of of IN cord-015021-pol2qm74 7400 35 bacteria bacteria NNS cord-015021-pol2qm74 7400 36 in in IN cord-015021-pol2qm74 7400 37 the the DT cord-015021-pol2qm74 7400 38 same same JJ cord-015021-pol2qm74 7400 39 compartments compartment NNS cord-015021-pol2qm74 7400 40 were be VBD cord-015021-pol2qm74 7400 41 substantially substantially RB cord-015021-pol2qm74 7400 42 reduced reduce VBN cord-015021-pol2qm74 7400 43 . . . cord-015021-pol2qm74 7401 1 Circulating circulate VBG cord-015021-pol2qm74 7401 2 LPS LPS NNP cord-015021-pol2qm74 7401 3 , , , cord-015021-pol2qm74 7401 4 TNF TNF NNP cord-015021-pol2qm74 7401 5 , , , cord-015021-pol2qm74 7401 6 Endothelin Endothelin NNP cord-015021-pol2qm74 7401 7 21 21 CD cord-015021-pol2qm74 7401 8 and and CC cord-015021-pol2qm74 7401 9 Lactate Lactate NNP cord-015021-pol2qm74 7401 10 were be VBD cord-015021-pol2qm74 7401 11 attenuated attenuate VBN cord-015021-pol2qm74 7401 12 the the DT cord-015021-pol2qm74 7401 13 first first JJ cord-015021-pol2qm74 7401 14 24 24 CD cord-015021-pol2qm74 7401 15 hours hour NNS cord-015021-pol2qm74 7401 16 after after IN cord-015021-pol2qm74 7401 17 CP cp NN cord-015021-pol2qm74 7401 18 . . . cord-015021-pol2qm74 7402 1 Neutrophil Neutrophil NNP cord-015021-pol2qm74 7402 2 myelopoiesis myelopoiesis NN cord-015021-pol2qm74 7402 3 is be VBZ cord-015021-pol2qm74 7402 4 augmented augment VBN cord-015021-pol2qm74 7402 5 with with IN cord-015021-pol2qm74 7402 6 increased increase VBN cord-015021-pol2qm74 7402 7 number number NN cord-015021-pol2qm74 7402 8 of of IN cord-015021-pol2qm74 7402 9 neutrophils neutrophil NNS cord-015021-pol2qm74 7402 10 in in IN cord-015021-pol2qm74 7402 11 blood blood NN cord-015021-pol2qm74 7402 12 and and CC cord-015021-pol2qm74 7402 13 peritoneal peritoneal JJ cord-015021-pol2qm74 7402 14 cavity cavity NN cord-015021-pol2qm74 7402 15 , , , cord-015021-pol2qm74 7402 16 resulting result VBG cord-015021-pol2qm74 7402 17 in in IN cord-015021-pol2qm74 7402 18 enhanced enhanced JJ cord-015021-pol2qm74 7402 19 clearance clearance NN cord-015021-pol2qm74 7402 20 of of IN cord-015021-pol2qm74 7402 21 pathogens pathogen NNS cord-015021-pol2qm74 7402 22 . . . cord-015021-pol2qm74 7403 1 LPS LPS NNP cord-015021-pol2qm74 7403 2 , , , cord-015021-pol2qm74 7403 3 TNF TNF NNP cord-015021-pol2qm74 7403 4 , , , cord-015021-pol2qm74 7403 5 Endothelin Endothelin NNP cord-015021-pol2qm74 7403 6 21 21 CD cord-015021-pol2qm74 7403 7 and and CC cord-015021-pol2qm74 7403 8 Lactate Lactate NNP cord-015021-pol2qm74 7403 9 are be VBP cord-015021-pol2qm74 7403 10 suppressed suppress VBN cord-015021-pol2qm74 7403 11 the the DT cord-015021-pol2qm74 7403 12 first first JJ cord-015021-pol2qm74 7403 13 24 24 CD cord-015021-pol2qm74 7403 14 hours hour NNS cord-015021-pol2qm74 7403 15 during during IN cord-015021-pol2qm74 7403 16 sepsis sepsis NN cord-015021-pol2qm74 7403 17 course course NN cord-015021-pol2qm74 7403 18 . . . cord-015021-pol2qm74 7404 1 A. A. NNP cord-015021-pol2qm74 7404 2 Wendel Wendel NNP cord-015021-pol2qm74 7404 3 , , , cord-015021-pol2qm74 7404 4 J. J. NNP cord-015021-pol2qm74 7404 5 Barsig Barsig NNP cord-015021-pol2qm74 7404 6 , , , cord-015021-pol2qm74 7404 7 G. G. NNP cord-015021-pol2qm74 7404 8 Tiegs Tiegs NNP cord-015021-pol2qm74 7404 9 GM GM NNP cord-015021-pol2qm74 7404 10 - - HYPH cord-015021-pol2qm74 7404 11 CSF CSF NNP cord-015021-pol2qm74 7404 12 stimulates stimulate VBZ cord-015021-pol2qm74 7404 13 the the DT cord-015021-pol2qm74 7404 14 proliferation proliferation NN cord-015021-pol2qm74 7404 15 and and CC cord-015021-pol2qm74 7404 16 differentiation differentiation NN cord-015021-pol2qm74 7404 17 of of IN cord-015021-pol2qm74 7404 18 granulocytic granulocytic JJ cord-015021-pol2qm74 7404 19 and and CC cord-015021-pol2qm74 7404 20 monocytic monocytic JJ cord-015021-pol2qm74 7404 21 progenitor progenitor NN cord-015021-pol2qm74 7404 22 cells cell NNS cord-015021-pol2qm74 7404 23 . . . cord-015021-pol2qm74 7405 1 In in IN cord-015021-pol2qm74 7405 2 addition addition NN cord-015021-pol2qm74 7405 3 the the DT cord-015021-pol2qm74 7405 4 hemopoietic hemopoietic JJ cord-015021-pol2qm74 7405 5 cytokine cytokine NN cord-015021-pol2qm74 7405 6 activates activate VBZ cord-015021-pol2qm74 7405 7 the the DT cord-015021-pol2qm74 7405 8 inflammatory inflammatory JJ cord-015021-pol2qm74 7405 9 response response NN cord-015021-pol2qm74 7405 10 in in IN cord-015021-pol2qm74 7405 11 mature mature JJ cord-015021-pol2qm74 7405 12 leukocytes leukocyte NNS cord-015021-pol2qm74 7405 13 . . . cord-015021-pol2qm74 7406 1 The the DT cord-015021-pol2qm74 7406 2 priming prime VBG cord-015021-pol2qm74 7406 3 effect effect NN cord-015021-pol2qm74 7406 4 of of IN cord-015021-pol2qm74 7406 5 GM GM NNP cord-015021-pol2qm74 7406 6 - - HYPH cord-015021-pol2qm74 7406 7 CSF CSF NNP cord-015021-pol2qm74 7406 8 towards towards IN cord-015021-pol2qm74 7406 9 lipopolysaccharide lipopolysaccharide NN cord-015021-pol2qm74 7406 10 ( ( -LRB- cord-015021-pol2qm74 7406 11 LPS)-induced lps)-induced JJ cord-015021-pol2qm74 7406 12 cytokine cytokine NN cord-015021-pol2qm74 7406 13 production production NN cord-015021-pol2qm74 7406 14 in in IN cord-015021-pol2qm74 7406 15 vitro vitro FW cord-015021-pol2qm74 7406 16 has have VBZ cord-015021-pol2qm74 7406 17 been be VBN cord-015021-pol2qm74 7406 18 described describe VBN cord-015021-pol2qm74 7406 19 , , , cord-015021-pol2qm74 7406 20 but but CC cord-015021-pol2qm74 7406 21 little little JJ cord-015021-pol2qm74 7406 22 is be VBZ cord-015021-pol2qm74 7406 23 known know VBN cord-015021-pol2qm74 7406 24 about about IN cord-015021-pol2qm74 7406 25 proinflammatory proinflammatory JJ cord-015021-pol2qm74 7406 26 GM GM NNP cord-015021-pol2qm74 7406 27 - - HYPH cord-015021-pol2qm74 7406 28 CSF csf NN cord-015021-pol2qm74 7406 29 effects effect NNS cord-015021-pol2qm74 7406 30 in in IN cord-015021-pol2qm74 7406 31 vivo vivo NN cord-015021-pol2qm74 7406 32 . . . cord-015021-pol2qm74 7407 1 We -PRON- PRP cord-015021-pol2qm74 7407 2 detected detect VBD cord-015021-pol2qm74 7407 3 GM GM NNP cord-015021-pol2qm74 7407 4 - - HYPH cord-015021-pol2qm74 7407 5 CSF CSF NNP cord-015021-pol2qm74 7407 6 in in IN cord-015021-pol2qm74 7407 7 plasma plasma NN cord-015021-pol2qm74 7407 8 of of IN cord-015021-pol2qm74 7407 9 LPS LPS NNP cord-015021-pol2qm74 7407 10 - - HYPH cord-015021-pol2qm74 7407 11 challenged challenge VBN cord-015021-pol2qm74 7407 12 mice mouse NNS cord-015021-pol2qm74 7407 13 with with IN cord-015021-pol2qm74 7407 14 kinetics kinetic NNS cord-015021-pol2qm74 7407 15 similar similar JJ cord-015021-pol2qm74 7407 16 to to IN cord-015021-pol2qm74 7407 17 TNF TNF NNP cord-015021-pol2qm74 7407 18 , , , cord-015021-pol2qm74 7407 19 reaching reach VBG cord-015021-pol2qm74 7407 20 peak peak NN cord-015021-pol2qm74 7407 21 levels level NNS cord-015021-pol2qm74 7407 22 2h 2h CD cord-015021-pol2qm74 7407 23 after after IN cord-015021-pol2qm74 7407 24 LPS LPS NNP cord-015021-pol2qm74 7407 25 administration administration NN cord-015021-pol2qm74 7407 26 . . . cord-015021-pol2qm74 7408 1 GM GM NNP cord-015021-pol2qm74 7408 2 - - HYPH cord-015021-pol2qm74 7408 3 CSF CSF NNP cord-015021-pol2qm74 7408 4 pretreatment pretreatment NN cord-015021-pol2qm74 7408 5 ( ( -LRB- cord-015021-pol2qm74 7408 6 50 50 CD cord-015021-pol2qm74 7408 7 ~tg ~tg NNS cord-015021-pol2qm74 7408 8 / / SYM cord-015021-pol2qm74 7408 9 kg kg NNP cord-015021-pol2qm74 7408 10 i.v i.v NNP cord-015021-pol2qm74 7408 11 . . . cord-015021-pol2qm74 7408 12 ) ) -RRB- cord-015021-pol2qm74 7409 1 enhanced enhanced JJ cord-015021-pol2qm74 7409 2 mortality mortality NN cord-015021-pol2qm74 7409 3 in in IN cord-015021-pol2qm74 7409 4 mice mouse NNS cord-015021-pol2qm74 7409 5 challenged challenge VBN cord-015021-pol2qm74 7409 6 by by IN cord-015021-pol2qm74 7409 7 a a DT cord-015021-pol2qm74 7409 8 sublethal sublethal JJ cord-015021-pol2qm74 7409 9 dose dose NN cord-015021-pol2qm74 7409 10 of of IN cord-015021-pol2qm74 7409 11 LPS LPS NNP cord-015021-pol2qm74 7409 12 . . . cord-015021-pol2qm74 7410 1 Plasma plasma NN cord-015021-pol2qm74 7410 2 levels level NNS cord-015021-pol2qm74 7410 3 of of IN cord-015021-pol2qm74 7410 4 Tumor tumor NN cord-015021-pol2qm74 7410 5 Necrosis necrosis NN cord-015021-pol2qm74 7410 6 Factor factor NN cord-015021-pol2qm74 7410 7 ( ( -LRB- cord-015021-pol2qm74 7410 8 TNF TNF NNP cord-015021-pol2qm74 7410 9 ) ) -RRB- cord-015021-pol2qm74 7410 10 and and CC cord-015021-pol2qm74 7410 11 Interleukin-6 Interleukin-6 NNP cord-015021-pol2qm74 7411 1 ( ( -LRB- cord-015021-pol2qm74 7411 2 IL-6 IL-6 NNP cord-015021-pol2qm74 7411 3 ) ) -RRB- cord-015021-pol2qm74 7411 4 were be VBD cord-015021-pol2qm74 7411 5 significantly significantly RB cord-015021-pol2qm74 7411 6 enhanced enhance VBN cord-015021-pol2qm74 7411 7 . . . cord-015021-pol2qm74 7412 1 A a DT cord-015021-pol2qm74 7412 2 monoclonal monoclonal JJ cord-015021-pol2qm74 7412 3 antibody antibody NN cord-015021-pol2qm74 7412 4 , , , cord-015021-pol2qm74 7412 5 which which WDT cord-015021-pol2qm74 7412 6 neutralizes neutralize VBZ cord-015021-pol2qm74 7412 7 GM GM NNP cord-015021-pol2qm74 7412 8 - - HYPH cord-015021-pol2qm74 7412 9 CSF csf NN cord-015021-pol2qm74 7412 10 bioactivity bioactivity NN cord-015021-pol2qm74 7412 11 , , , cord-015021-pol2qm74 7412 12 rendered render VBN cord-015021-pol2qm74 7412 13 mice mouse NNS cord-015021-pol2qm74 7412 14 less less RBR cord-015021-pol2qm74 7412 15 sensitive sensitive JJ cord-015021-pol2qm74 7412 16 towards towards IN cord-015021-pol2qm74 7412 17 lethal lethal JJ cord-015021-pol2qm74 7412 18 LPS LPS NNP cord-015021-pol2qm74 7412 19 - - HYPH cord-015021-pol2qm74 7412 20 challenge challenge NN cord-015021-pol2qm74 7412 21 . . . cord-015021-pol2qm74 7413 1 TNF TNF NNP cord-015021-pol2qm74 7413 2 - - HYPH cord-015021-pol2qm74 7413 3 and and CC cord-015021-pol2qm74 7413 4 IL-6-tevels il-6-tevel NNS cord-015021-pol2qm74 7413 5 were be VBD cord-015021-pol2qm74 7413 6 reduced reduce VBN cord-015021-pol2qm74 7413 7 in in IN cord-015021-pol2qm74 7413 8 these these DT cord-015021-pol2qm74 7413 9 mice mouse NNS cord-015021-pol2qm74 7413 10 compared compare VBN cord-015021-pol2qm74 7413 11 to to TO cord-015021-pol2qm74 7413 12 control control VB cord-015021-pol2qm74 7413 13 animals animal NNS cord-015021-pol2qm74 7413 14 without without IN cord-015021-pol2qm74 7413 15 antibody antibody NN cord-015021-pol2qm74 7413 16 treatment treatment NN cord-015021-pol2qm74 7413 17 . . . cord-015021-pol2qm74 7414 1 In in IN cord-015021-pol2qm74 7414 2 addition addition NN cord-015021-pol2qm74 7414 3 , , , cord-015021-pol2qm74 7414 4 severalfold severalfold JJ cord-015021-pol2qm74 7414 5 potentiation potentiation NN cord-015021-pol2qm74 7414 6 of of IN cord-015021-pol2qm74 7414 7 LPS LPS NNP cord-015021-pol2qm74 7414 8 - - HYPH cord-015021-pol2qm74 7414 9 induced induce VBN cord-015021-pol2qm74 7414 10 cytokine cytokine NN cord-015021-pol2qm74 7414 11 release release NN cord-015021-pol2qm74 7414 12 by by IN cord-015021-pol2qm74 7414 13 GM GM NNP cord-015021-pol2qm74 7414 14 - - HYPH cord-015021-pol2qm74 7414 15 CSF CSF NNP cord-015021-pol2qm74 7414 16 was be VBD cord-015021-pol2qm74 7414 17 observed observe VBN cord-015021-pol2qm74 7414 18 in in IN cord-015021-pol2qm74 7414 19 vitro vitro FW cord-015021-pol2qm74 7414 20 in in IN cord-015021-pol2qm74 7414 21 murine murine JJ cord-015021-pol2qm74 7414 22 bone bone NN cord-015021-pol2qm74 7414 23 marrow marrow NN cord-015021-pol2qm74 7414 24 cell cell NN cord-015021-pol2qm74 7414 25 cultures culture NNS cord-015021-pol2qm74 7414 26 . . . cord-015021-pol2qm74 7415 1 These these DT cord-015021-pol2qm74 7415 2 data datum NNS cord-015021-pol2qm74 7415 3 demonstrate demonstrate VBP cord-015021-pol2qm74 7415 4 the the DT cord-015021-pol2qm74 7415 5 proinflammatory proinflammatory JJ cord-015021-pol2qm74 7415 6 capacity capacity NN cord-015021-pol2qm74 7415 7 of of IN cord-015021-pol2qm74 7415 8 GM GM NNP cord-015021-pol2qm74 7415 9 - - HYPH cord-015021-pol2qm74 7415 10 CSF CSF NNP cord-015021-pol2qm74 7415 11 and and CC cord-015021-pol2qm74 7415 12 suggest suggest VBP cord-015021-pol2qm74 7415 13 that that IN cord-015021-pol2qm74 7415 14 the the DT cord-015021-pol2qm74 7415 15 hemopoietic hemopoietic JJ cord-015021-pol2qm74 7415 16 cytokine cytokine NN cord-015021-pol2qm74 7415 17 plays play VBZ cord-015021-pol2qm74 7415 18 also also RB cord-015021-pol2qm74 7415 19 a a DT cord-015021-pol2qm74 7415 20 role role NN cord-015021-pol2qm74 7415 21 as as IN cord-015021-pol2qm74 7415 22 an an DT cord-015021-pol2qm74 7415 23 endogenous endogenous JJ cord-015021-pol2qm74 7415 24 modulator modulator NN cord-015021-pol2qm74 7415 25 of of IN cord-015021-pol2qm74 7415 26 LPS LPS NNP cord-015021-pol2qm74 7415 27 toxicity toxicity NN cord-015021-pol2qm74 7415 28 . . . cord-015021-pol2qm74 7416 1 Immune immune JJ cord-015021-pol2qm74 7416 2 dysfunction dysfunction NN cord-015021-pol2qm74 7416 3 , , , cord-015021-pol2qm74 7416 4 developing develop VBG cord-015021-pol2qm74 7416 5 in in IN cord-015021-pol2qm74 7416 6 the the DT cord-015021-pol2qm74 7416 7 wake wake NN cord-015021-pol2qm74 7416 8 of of IN cord-015021-pol2qm74 7416 9 multiple multiple JJ cord-015021-pol2qm74 7416 10 trauma trauma NN cord-015021-pol2qm74 7416 11 , , , cord-015021-pol2qm74 7416 12 overwhelming overwhelming JJ cord-015021-pol2qm74 7416 13 infection infection NN cord-015021-pol2qm74 7416 14 and and CC cord-015021-pol2qm74 7416 15 other other JJ cord-015021-pol2qm74 7416 16 forms form NNS cord-015021-pol2qm74 7416 17 of of IN cord-015021-pol2qm74 7416 18 critical critical JJ cord-015021-pol2qm74 7416 19 surgical surgical JJ cord-015021-pol2qm74 7416 20 illnes% illnes% NN cord-015021-pol2qm74 7416 21 is be VBZ cord-015021-pol2qm74 7416 22 associated associate VBN cord-015021-pol2qm74 7416 23 with with IN cord-015021-pol2qm74 7416 24 increased increase VBN cord-015021-pol2qm74 7416 25 infections infection NNS cord-015021-pol2qm74 7416 26 , , , cord-015021-pol2qm74 7416 27 morbidity morbidity NN cord-015021-pol2qm74 7416 28 and and CC cord-015021-pol2qm74 7416 29 mortality mortality NN cord-015021-pol2qm74 7416 30 . . . cord-015021-pol2qm74 7417 1 The the DT cord-015021-pol2qm74 7417 2 mechanisms mechanism NNS cord-015021-pol2qm74 7417 3 responsible responsible JJ cord-015021-pol2qm74 7417 4 for for IN cord-015021-pol2qm74 7417 5 alterations alteration NNS cord-015021-pol2qm74 7417 6 in in IN cord-015021-pol2qm74 7417 7 immune immune JJ cord-015021-pol2qm74 7417 8 regulation regulation NN cord-015021-pol2qm74 7417 9 are be VBP cord-015021-pol2qm74 7417 10 incompletely incompletely RB cord-015021-pol2qm74 7417 11 understood understand VBN cord-015021-pol2qm74 7417 12 but but CC cord-015021-pol2qm74 7417 13 monocyte monocyte NNP cord-015021-pol2qm74 7417 14 appear appear VBP cord-015021-pol2qm74 7417 15 to to TO cord-015021-pol2qm74 7417 16 play play VB cord-015021-pol2qm74 7417 17 a a DT cord-015021-pol2qm74 7417 18 central central JJ cord-015021-pol2qm74 7417 19 role role NN cord-015021-pol2qm74 7417 20 . . . cord-015021-pol2qm74 7418 1 Polymorphonuclear polymorphonuclear JJ cord-015021-pol2qm74 7418 2 leukocytes leukocyte NNS cord-015021-pol2qm74 7418 3 ( ( -LRB- cord-015021-pol2qm74 7418 4 PMN PMN NNP cord-015021-pol2qm74 7418 5 ) ) -RRB- cord-015021-pol2qm74 7418 6 are be VBP cord-015021-pol2qm74 7418 7 known know VBN cord-015021-pol2qm74 7418 8 to to TO cord-015021-pol2qm74 7418 9 play play VB cord-015021-pol2qm74 7418 10 a a DT cord-015021-pol2qm74 7418 11 central central JJ cord-015021-pol2qm74 7418 12 role role NN cord-015021-pol2qm74 7418 13 in in IN cord-015021-pol2qm74 7418 14 the the DT cord-015021-pol2qm74 7418 15 inflammatory inflammatory JJ cord-015021-pol2qm74 7418 16 response response NN cord-015021-pol2qm74 7418 17 of of IN cord-015021-pol2qm74 7418 18 the the DT cord-015021-pol2qm74 7418 19 host host NN cord-015021-pol2qm74 7418 20 toward toward IN cord-015021-pol2qm74 7418 21 invading invade VBG cord-015021-pol2qm74 7418 22 microrganisms microrganism NNS cord-015021-pol2qm74 7418 23 . . . cord-015021-pol2qm74 7419 1 Reports report NNS cord-015021-pol2qm74 7419 2 of of IN cord-015021-pol2qm74 7419 3 defects defect NNS cord-015021-pol2qm74 7419 4 in in IN cord-015021-pol2qm74 7419 5 all all PDT cord-015021-pol2qm74 7419 6 the the DT cord-015021-pol2qm74 7419 7 aspeots aspeot NNS cord-015021-pol2qm74 7419 8 of of IN cord-015021-pol2qm74 7419 9 PMN PMN NNP cord-015021-pol2qm74 7419 10 function function NN cord-015021-pol2qm74 7419 11 have have VBP cord-015021-pol2qm74 7419 12 been be VBN cord-015021-pol2qm74 7419 13 accumulated accumulate VBN cord-015021-pol2qm74 7419 14 in in IN cord-015021-pol2qm74 7419 15 recent recent JJ cord-015021-pol2qm74 7419 16 years year NNS cord-015021-pol2qm74 7419 17 . . . cord-015021-pol2qm74 7420 1 The the DT cord-015021-pol2qm74 7420 2 possible possible JJ cord-015021-pol2qm74 7420 3 role role NN cord-015021-pol2qm74 7420 4 of of IN cord-015021-pol2qm74 7420 5 GM GM NNP cord-015021-pol2qm74 7420 6 - - HYPH cord-015021-pol2qm74 7420 7 CSF CSF NNP cord-015021-pol2qm74 7420 8 in in IN cord-015021-pol2qm74 7420 9 modifing modife VBG cord-015021-pol2qm74 7420 10 the the DT cord-015021-pol2qm74 7420 11 state state NN cord-015021-pol2qm74 7420 12 of of IN cord-015021-pol2qm74 7420 13 immuno immuno JJ cord-015021-pol2qm74 7420 14 suppression suppression NN cord-015021-pol2qm74 7420 15 detected detect VBN cord-015021-pol2qm74 7420 16 in in IN cord-015021-pol2qm74 7420 17 severe severe JJ cord-015021-pol2qm74 7420 18 intraabdominal intraabdominal JJ cord-015021-pol2qm74 7420 19 infected infected JJ cord-015021-pol2qm74 7420 20 pt~. pt~. JJ cord-015021-pol2qm74 7420 21 inspite inspite NN cord-015021-pol2qm74 7420 22 of of IN cord-015021-pol2qm74 7420 23 surgical surgical JJ cord-015021-pol2qm74 7420 24 appropriate appropriate JJ cord-015021-pol2qm74 7420 25 procedures procedure NNS cord-015021-pol2qm74 7420 26 and and CC cord-015021-pol2qm74 7420 27 in in IN cord-015021-pol2qm74 7420 28 reducing reduce VBG cord-015021-pol2qm74 7420 29 the the DT cord-015021-pol2qm74 7420 30 expected expect VBN cord-015021-pol2qm74 7420 31 mortality mortality NN cord-015021-pol2qm74 7420 32 is be VBZ cord-015021-pol2qm74 7420 33 investigated investigate VBN cord-015021-pol2qm74 7420 34 . . . cord-015021-pol2qm74 7421 1 The the DT cord-015021-pol2qm74 7421 2 safety safety NN cord-015021-pol2qm74 7421 3 of of IN cord-015021-pol2qm74 7421 4 rh rh NNP cord-015021-pol2qm74 7421 5 - - HYPH cord-015021-pol2qm74 7421 6 GM GM NNP cord-015021-pol2qm74 7421 7 - - HYPH cord-015021-pol2qm74 7421 8 CSF CSF NNP cord-015021-pol2qm74 7421 9 administration administration NN cord-015021-pol2qm74 7421 10 in in IN cord-015021-pol2qm74 7421 11 sepsis sepsis NN cord-015021-pol2qm74 7421 12 is be VBZ cord-015021-pol2qm74 7421 13 also also RB cord-015021-pol2qm74 7421 14 evaluated evaluate VBN cord-015021-pol2qm74 7421 15 . . . cord-015021-pol2qm74 7422 1 A a DT cord-015021-pol2qm74 7422 2 double double JJ cord-015021-pol2qm74 7422 3 blind blind JJ cord-015021-pol2qm74 7422 4 randomized randomized JJ cord-015021-pol2qm74 7422 5 study study NN cord-015021-pol2qm74 7422 6 is be VBZ cord-015021-pol2qm74 7422 7 proposed propose VBN cord-015021-pol2qm74 7422 8 . . . cord-015021-pol2qm74 7423 1 This this DT cord-015021-pol2qm74 7423 2 study study NN cord-015021-pol2qm74 7423 3 include include VBP cord-015021-pol2qm74 7423 4 60 60 CD cord-015021-pol2qm74 7423 5 ICU ICU NNP cord-015021-pol2qm74 7423 6 patients patient NNS cord-015021-pol2qm74 7423 7 who who WP cord-015021-pol2qm74 7423 8 do do VBP cord-015021-pol2qm74 7423 9 not not RB cord-015021-pol2qm74 7423 10 exhibit exhibit VB cord-015021-pol2qm74 7423 11 signs sign NNS cord-015021-pol2qm74 7423 12 of of IN cord-015021-pol2qm74 7423 13 shock shock NN cord-015021-pol2qm74 7423 14 and/or and/or CC cord-015021-pol2qm74 7423 15 ARDS ARDS NNP cord-015021-pol2qm74 7423 16 , , , cord-015021-pol2qm74 7423 17 with with IN cord-015021-pol2qm74 7423 18 clinical clinical JJ cord-015021-pol2qm74 7423 19 signs sign NNS cord-015021-pol2qm74 7423 20 and and CC cord-015021-pol2qm74 7423 21 symptoms symptom NNS cord-015021-pol2qm74 7423 22 of of IN cord-015021-pol2qm74 7423 23 abdominal abdominal JJ cord-015021-pol2qm74 7423 24 infection infection NN cord-015021-pol2qm74 7423 25 . . . cord-015021-pol2qm74 7424 1 Immunodepressed immunodepressed JJ cord-015021-pol2qm74 7424 2 patients patient NNS cord-015021-pol2qm74 7424 3 - - HYPH cord-015021-pol2qm74 7424 4 AIDS AIDS NNP cord-015021-pol2qm74 7424 5 , , , cord-015021-pol2qm74 7424 6 Chronic chronic JJ cord-015021-pol2qm74 7424 7 chemotherapy chemotherapy NN cord-015021-pol2qm74 7424 8 or or CC cord-015021-pol2qm74 7424 9 chronic chronic JJ cord-015021-pol2qm74 7424 10 steroid steroid NN cord-015021-pol2qm74 7424 11 administration administration NN cord-015021-pol2qm74 7424 12 do do VBP cord-015021-pol2qm74 7424 13 not not RB cord-015021-pol2qm74 7424 14 partecipate partecipate VB cord-015021-pol2qm74 7424 15 to to IN cord-015021-pol2qm74 7424 16 the the DT cord-015021-pol2qm74 7424 17 study study NN cord-015021-pol2qm74 7424 18 . . . cord-015021-pol2qm74 7425 1 Patients patient NNS cord-015021-pol2qm74 7425 2 will will MD cord-015021-pol2qm74 7425 3 receive receive VB cord-015021-pol2qm74 7425 4 rGM rGM VBN cord-015021-pol2qm74 7425 5 - - HYPH cord-015021-pol2qm74 7425 6 CSF csf NN cord-015021-pol2qm74 7425 7 ( ( -LRB- cord-015021-pol2qm74 7425 8 l l NN cord-015021-pol2qm74 7425 9 ~ ~ CD cord-015021-pol2qm74 7425 10 g g NN cord-015021-pol2qm74 7425 11 / / SYM cord-015021-pol2qm74 7425 12 Kg Kg NNP cord-015021-pol2qm74 7425 13 / / SYM cord-015021-pol2qm74 7425 14 day day NN cord-015021-pol2qm74 7425 15 ) ) -RRB- cord-015021-pol2qm74 7425 16 or or CC cord-015021-pol2qm74 7425 17 placebo placebo NN cord-015021-pol2qm74 7425 18 in in IN cord-015021-pol2qm74 7425 19 24 24 CD cord-015021-pol2qm74 7425 20 hs hs NNP cord-015021-pol2qm74 7425 21 . . . cord-015021-pol2qm74 7426 1 continuous continuous JJ cord-015021-pol2qm74 7426 2 infusion infusion NN cord-015021-pol2qm74 7426 3 for for IN cord-015021-pol2qm74 7426 4 15 15 CD cord-015021-pol2qm74 7426 5 days day NNS cord-015021-pol2qm74 7426 6 . . . cord-015021-pol2qm74 7427 1 SafetyandefYieacy SafetyandefYieacy NNP cord-015021-pol2qm74 7427 2 will will MD cord-015021-pol2qm74 7427 3 be be VB cord-015021-pol2qm74 7427 4 assessed assess VBN cord-015021-pol2qm74 7427 5 till till IN cord-015021-pol2qm74 7427 6 to to IN cord-015021-pol2qm74 7427 7 Day Day NNP cord-015021-pol2qm74 7427 8 30 30 CD cord-015021-pol2qm74 7427 9 . . . cord-015021-pol2qm74 7428 1 The the DT cord-015021-pol2qm74 7428 2 APACHE APACHE NNP cord-015021-pol2qm74 7428 3 II II NNP cord-015021-pol2qm74 7428 4 Score Score NNP cord-015021-pol2qm74 7428 5 is be VBZ cord-015021-pol2qm74 7428 6 adopted adopt VBN cord-015021-pol2qm74 7428 7 for for IN cord-015021-pol2qm74 7428 8 risk risk NN cord-015021-pol2qm74 7428 9 stratification stratification NN cord-015021-pol2qm74 7428 10 of of IN cord-015021-pol2qm74 7428 11 patients patient NNS cord-015021-pol2qm74 7428 12 because because IN cord-015021-pol2qm74 7428 13 it -PRON- PRP cord-015021-pol2qm74 7428 14 is be VBZ cord-015021-pol2qm74 7428 15 reliable reliable JJ cord-015021-pol2qm74 7428 16 and and CC cord-015021-pol2qm74 7428 17 validated validated JJ cord-015021-pol2qm74 7428 18 , , , cord-015021-pol2qm74 7428 19 objective objective JJ cord-015021-pol2qm74 7428 20 and and CC cord-015021-pol2qm74 7428 21 composed compose VBN cord-015021-pol2qm74 7428 22 of of IN cord-015021-pol2qm74 7428 23 information information NN cord-015021-pol2qm74 7428 24 that that WDT cord-015021-pol2qm74 7428 25 is be VBZ cord-015021-pol2qm74 7428 26 indipendent indipendent JJ cord-015021-pol2qm74 7428 27 of of IN cord-015021-pol2qm74 7428 28 diagnostic diagnostic JJ cord-015021-pol2qm74 7428 29 criteria criterion NNS cord-015021-pol2qm74 7428 30 . . . cord-015021-pol2qm74 7429 1 Patient Patient NNP cord-015021-pol2qm74 7429 2 's 's POS cord-015021-pol2qm74 7429 3 entry entry NN cord-015021-pol2qm74 7429 4 criteria criterion NNS cord-015021-pol2qm74 7429 5 is be VBZ cord-015021-pol2qm74 7429 6 APACHE APACHE NNP cord-015021-pol2qm74 7429 7 II II NNP cord-015021-pol2qm74 7430 1 > > XX cord-015021-pol2qm74 7431 1 16 16 CD cord-015021-pol2qm74 7431 2 ( ( -LRB- cord-015021-pol2qm74 7431 3 Score score NN cord-015021-pol2qm74 7431 4 16 16 CD cord-015021-pol2qm74 7431 5 corresponds correspond VBZ cord-015021-pol2qm74 7431 6 to to IN cord-015021-pol2qm74 7431 7 expected expect VBN cord-015021-pol2qm74 7431 8 mortality mortality NN cord-015021-pol2qm74 7431 9 rate rate NN cord-015021-pol2qm74 7431 10 of of IN cord-015021-pol2qm74 7431 11 38%).In 38%).in CD cord-015021-pol2qm74 7431 12 this this DT cord-015021-pol2qm74 7431 13 protocol protocol NN cord-015021-pol2qm74 7432 1 the the DT cord-015021-pol2qm74 7432 2 surgeons surgeon NNS cord-015021-pol2qm74 7432 3 report report VBP cord-015021-pol2qm74 7432 4 the the DT cord-015021-pol2qm74 7432 5 judgement judgement NN cord-015021-pol2qm74 7432 6 of of IN cord-015021-pol2qm74 7432 7 the the DT cord-015021-pol2qm74 7432 8 efficacy efficacy NN cord-015021-pol2qm74 7432 9 of of IN cord-015021-pol2qm74 7432 10 surgical surgical JJ cord-015021-pol2qm74 7432 11 procedure procedure NN cord-015021-pol2qm74 7432 12 to to TO cord-015021-pol2qm74 7432 13 remove remove VB cord-015021-pol2qm74 7432 14 or or CC cord-015021-pol2qm74 7432 15 not not RB cord-015021-pol2qm74 7432 16 the the DT cord-015021-pol2qm74 7432 17 focus focus NN cord-015021-pol2qm74 7432 18 of of IN cord-015021-pol2qm74 7432 19 infection infection NN cord-015021-pol2qm74 7432 20 . . . cord-015021-pol2qm74 7433 1 Objectives objective NNS cord-015021-pol2qm74 7433 2 : : : cord-015021-pol2qm74 7433 3 Infections infection NNS cord-015021-pol2qm74 7433 4 and and CC cord-015021-pol2qm74 7433 5 subsequent subsequent JJ cord-015021-pol2qm74 7433 6 septic septic JJ cord-015021-pol2qm74 7433 7 responses response NNS cord-015021-pol2qm74 7433 8 remain remain VBP cord-015021-pol2qm74 7433 9 the the DT cord-015021-pol2qm74 7433 10 leading leading JJ cord-015021-pol2qm74 7433 11 cause cause NN cord-015021-pol2qm74 7433 12 of of IN cord-015021-pol2qm74 7433 13 death death NN cord-015021-pol2qm74 7433 14 among among IN cord-015021-pol2qm74 7433 15 surgical surgical JJ cord-015021-pol2qm74 7433 16 intensive intensive JJ cord-015021-pol2qm74 7433 17 care care NN cord-015021-pol2qm74 7433 18 ( ( -LRB- cord-015021-pol2qm74 7433 19 SICU SICU NNP cord-015021-pol2qm74 7433 20 ) ) -RRB- cord-015021-pol2qm74 7433 21 patients patient NNS cord-015021-pol2qm74 7433 22 despite despite IN cord-015021-pol2qm74 7433 23 tmprovetaunts tmprovetaunt NNS cord-015021-pol2qm74 7433 24 in in IN cord-015021-pol2qm74 7433 25 supportive supportive JJ cord-015021-pol2qm74 7433 26 care care NN cord-015021-pol2qm74 7433 27 and and CC cord-015021-pol2qm74 7433 28 brond brond NNP cord-015021-pol2qm74 7433 29 - - HYPH cord-015021-pol2qm74 7433 30 epectrum epectrum NN cord-015021-pol2qm74 7433 31 antibiotics antibiotic NNS cord-015021-pol2qm74 7433 32 . . . cord-015021-pol2qm74 7434 1 Usually usually RB cord-015021-pol2qm74 7434 2 invading invade VBG cord-015021-pol2qm74 7434 3 bacteria bacteria NNS cord-015021-pol2qm74 7434 4 are be VBP cord-015021-pol2qm74 7434 5 efficiently efficiently RB cord-015021-pol2qm74 7434 6 cleared clear VBN cord-015021-pol2qm74 7434 7 by by IN cord-015021-pol2qm74 7434 8 neutrophil neutrophil NN cord-015021-pol2qm74 7434 9 granulocytes granulocyte NNS cord-015021-pol2qm74 7434 10 . . . cord-015021-pol2qm74 7435 1 However however RB cord-015021-pol2qm74 7435 2 , , , cord-015021-pol2qm74 7435 3 during during IN cord-015021-pol2qm74 7435 4 sepsis sepsis NN cord-015021-pol2qm74 7435 5 various various JJ cord-015021-pol2qm74 7435 6 neatrophil neatrophil NN cord-015021-pol2qm74 7435 7 dysfunctions dysfunction NNS cord-015021-pol2qm74 7435 8 have have VBP cord-015021-pol2qm74 7435 9 been be VBN cord-015021-pol2qm74 7435 10 demonstrated demonstrate VBN cord-015021-pol2qm74 7435 11 , , , cord-015021-pol2qm74 7435 12 leading lead VBG cord-015021-pol2qm74 7435 13 to to IN cord-015021-pol2qm74 7435 14 impaired impaired JJ cord-015021-pol2qm74 7435 15 host host NN cord-015021-pol2qm74 7435 16 defense defense NN cord-015021-pol2qm74 7435 17 . . . cord-015021-pol2qm74 7436 1 Granulocyte Granulocyte NNP cord-015021-pol2qm74 7436 2 colony colony NN cord-015021-pol2qm74 7436 3 - - HYPH cord-015021-pol2qm74 7436 4 stimulating stimulate VBG cord-015021-pol2qm74 7436 5 factor factor NN cord-015021-pol2qm74 7436 6 ( ( -LRB- cord-015021-pol2qm74 7436 7 G G NNP cord-015021-pol2qm74 7436 8 - - HYPH cord-015021-pol2qm74 7436 9 CSF CSF NNP cord-015021-pol2qm74 7436 10 ) ) -RRB- cord-015021-pol2qm74 7436 11 induces induce VBZ cord-015021-pol2qm74 7436 12 a a DT cord-015021-pol2qm74 7436 13 sustained sustained JJ cord-015021-pol2qm74 7436 14 increase increase NN cord-015021-pol2qm74 7436 15 in in IN cord-015021-pol2qm74 7436 16 circulating circulate VBG cord-015021-pol2qm74 7436 17 neutrophils neutrophil NNS cord-015021-pol2qm74 7436 18 and and CC cord-015021-pol2qm74 7436 19 enhances enhance VBZ cord-015021-pol2qm74 7436 20 various various JJ cord-015021-pol2qm74 7436 21 noutrophil noutrophil NNP cord-015021-pol2qm74 7436 22 functions function NNS cord-015021-pol2qm74 7436 23 . . . cord-015021-pol2qm74 7437 1 It -PRON- PRP cord-015021-pol2qm74 7437 2 was be VBD cord-015021-pol2qm74 7437 3 the the DT cord-015021-pol2qm74 7437 4 purpose purpose NN cord-015021-pol2qm74 7437 5 of of IN cord-015021-pol2qm74 7437 6 the the DT cord-015021-pol2qm74 7437 7 present present JJ cord-015021-pol2qm74 7437 8 study study NN cord-015021-pol2qm74 7437 9 , , , cord-015021-pol2qm74 7437 10 to to TO cord-015021-pol2qm74 7437 11 evaluate evaluate VB cord-015021-pol2qm74 7437 12 the the DT cord-015021-pol2qm74 7437 13 safety safety NN cord-015021-pol2qm74 7437 14 and and CC cord-015021-pol2qm74 7437 15 efficacy efficacy NN cord-015021-pol2qm74 7437 16 of of IN cord-015021-pol2qm74 7437 17 G G NNP cord-015021-pol2qm74 7437 18 - - HYPH cord-015021-pol2qm74 7437 19 CSF CSF NNP cord-015021-pol2qm74 7437 20 ( ( -LRB- cord-015021-pol2qm74 7437 21 filgrastim filgrastim NNP cord-015021-pol2qm74 7437 22 ) ) -RRB- cord-015021-pol2qm74 7437 23 in in IN cord-015021-pol2qm74 7437 24 SICU SICU NNP cord-015021-pol2qm74 7437 25 patients patient NNS cord-015021-pol2qm74 7437 26 at at IN cord-015021-pol2qm74 7437 27 risk risk NN cord-015021-pol2qm74 7437 28 of of IN cord-015021-pol2qm74 7437 29 sepsis sepsis NN cord-015021-pol2qm74 7437 30 . . . cord-015021-pol2qm74 7438 1 Materiel Materiel NNP cord-015021-pol2qm74 7438 2 a.d a.d NNP cord-015021-pol2qm74 7438 3 Methods Methods NNPS cord-015021-pol2qm74 7438 4 : : : cord-015021-pol2qm74 7438 5 The the DT cord-015021-pol2qm74 7438 6 study study NN cord-015021-pol2qm74 7438 7 was be VBD cord-015021-pol2qm74 7438 8 designed design VBN cord-015021-pol2qm74 7438 9 as as IN cord-015021-pol2qm74 7438 10 an an DT cord-015021-pol2qm74 7438 11 open open JJ cord-015021-pol2qm74 7438 12 - - HYPH cord-015021-pol2qm74 7438 13 label label NN cord-015021-pol2qm74 7438 14 phase phase NN cord-015021-pol2qm74 7438 15 - - HYPH cord-015021-pol2qm74 7438 16 ll ll JJ cord-015021-pol2qm74 7438 17 study study NN cord-015021-pol2qm74 7438 18 of of IN cord-015021-pol2qm74 7438 19 filgrastim filgrastim NNP cord-015021-pol2qm74 7438 20 . . . cord-015021-pol2qm74 7439 1 Ten ten CD cord-015021-pol2qm74 7439 2 consecutive consecutive JJ cord-015021-pol2qm74 7439 3 SlCU SlCU NNP cord-015021-pol2qm74 7439 4 patients patient NNS cord-015021-pol2qm74 7439 5 , , , cord-015021-pol2qm74 7439 6 with with IN cord-015021-pol2qm74 7439 7 a a DT cord-015021-pol2qm74 7439 8 Therapeutic Therapeutic NNP cord-015021-pol2qm74 7439 9 Interveotion Interveotion NNP cord-015021-pol2qm74 7439 10 Score score NN cord-015021-pol2qm74 7439 11 greater great JJR cord-015021-pol2qm74 7439 12 than than IN cord-015021-pol2qm74 7439 13 30 30 CD cord-015021-pol2qm74 7439 14 , , , cord-015021-pol2qm74 7439 15 were be VBD cord-015021-pol2qm74 7439 16 included include VBN cord-015021-pol2qm74 7439 17 in in IN cord-015021-pol2qm74 7439 18 the the DT cord-015021-pol2qm74 7439 19 study study NN cord-015021-pol2qm74 7439 20 . . . cord-015021-pol2qm74 7440 1 Filgrastim Filgrastim NNP cord-015021-pol2qm74 7440 2 was be VBD cord-015021-pol2qm74 7440 3 given give VBN cord-015021-pol2qm74 7440 4 by by IN cord-015021-pol2qm74 7440 5 daily daily JJ cord-015021-pol2qm74 7440 6 continuous continuous JJ cord-015021-pol2qm74 7440 7 intravenous intravenous JJ cord-015021-pol2qm74 7440 8 infusion infusion NN cord-015021-pol2qm74 7440 9 for for IN cord-015021-pol2qm74 7440 10 7 7 CD cord-015021-pol2qm74 7440 11 days day NNS cord-015021-pol2qm74 7440 12 or or CC cord-015021-pol2qm74 7440 13 discharge discharge VB cord-015021-pol2qm74 7440 14 from from IN cord-015021-pol2qm74 7440 15 the the DT cord-015021-pol2qm74 7440 16 SICU SICU NNP cord-015021-pol2qm74 7440 17 . . . cord-015021-pol2qm74 7441 1 APACHE APACHE NNP cord-015021-pol2qm74 7441 2 ll ll NNP cord-015021-pol2qm74 7441 3 - - HYPH cord-015021-pol2qm74 7441 4 score score NN cord-015021-pol2qm74 7441 5 , , , cord-015021-pol2qm74 7441 6 multiple multiple JJ cord-015021-pol2qm74 7441 7 - - HYPH cord-015021-pol2qm74 7441 8 organ organ NN cord-015021-pol2qm74 7441 9 - - HYPH cord-015021-pol2qm74 7441 10 failure failure NN cord-015021-pol2qm74 7441 11 ( ( -LRB- cord-015021-pol2qm74 7441 12 MOF MOF NNP cord-015021-pol2qm74 7441 13 ) ) -RRB- cord-015021-pol2qm74 7441 14 score score NN cord-015021-pol2qm74 7441 15 , , , cord-015021-pol2qm74 7441 16 definitions definition NNS cord-015021-pol2qm74 7441 17 of of IN cord-015021-pol2qm74 7441 18 infections infection NNS cord-015021-pol2qm74 7441 19 , , , cord-015021-pol2qm74 7441 20 sepsis sepsis NN cord-015021-pol2qm74 7441 21 , , , cord-015021-pol2qm74 7441 22 systemic systemic JJ cord-015021-pol2qm74 7441 23 inflammatory inflammatory JJ cord-015021-pol2qm74 7441 24 response response NN cord-015021-pol2qm74 7441 25 syndrome syndrome NN cord-015021-pol2qm74 7441 26 ( ( -LRB- cord-015021-pol2qm74 7441 27 SIRS SIRS NNP cord-015021-pol2qm74 7441 28 ) ) -RRB- cord-015021-pol2qm74 7441 29 , , , cord-015021-pol2qm74 7441 30 and and CC cord-015021-pol2qm74 7441 31 acute acute JJ cord-015021-pol2qm74 7441 32 respiratory respiratory JJ cord-015021-pol2qm74 7441 33 failure failure NN cord-015021-pol2qm74 7441 34 were be VBD cord-015021-pol2qm74 7441 35 applied apply VBN cord-015021-pol2qm74 7441 36 daily daily RB cord-015021-pol2qm74 7441 37 . . . cord-015021-pol2qm74 7442 1 A a DT cord-015021-pol2qm74 7442 2 response response NN cord-015021-pol2qm74 7442 3 to to IN cord-015021-pol2qm74 7442 4 filgrastinl filgrastinl NNP cord-015021-pol2qm74 7442 5 th_erapy th_erapy NNP cord-015021-pol2qm74 7442 6 was be VBD cord-015021-pol2qm74 7442 7 defined define VBN cord-015021-pol2qm74 7442 8 as as IN cord-015021-pol2qm74 7442 9 an an DT cord-015021-pol2qm74 7442 10 improvement improvement NN cord-015021-pol2qm74 7442 11 in in IN cord-015021-pol2qm74 7442 12 disease disease NN cord-015021-pol2qm74 7442 13 severity severity NN cord-015021-pol2qm74 7442 14 quantified quantify VBN cord-015021-pol2qm74 7442 15 by by IN cord-015021-pol2qm74 7442 16 a a DT cord-015021-pol2qm74 7442 17 decrease decrease NN cord-015021-pol2qm74 7442 18 of of IN cord-015021-pol2qm74 7442 19 > > XX cord-015021-pol2qm74 7442 20 4 4 CD cord-015021-pol2qm74 7442 21 APACHE APACHE NNP cord-015021-pol2qm74 7442 22 1I 1i CD cord-015021-pol2qm74 7442 23 score score NN cord-015021-pol2qm74 7442 24 points point NNS cord-015021-pol2qm74 7442 25 on on IN cord-015021-pol2qm74 7442 26 day day NN cord-015021-pol2qm74 7442 27 4 4 CD cord-015021-pol2qm74 7442 28 after after IN cord-015021-pol2qm74 7442 29 onset onset NN cord-015021-pol2qm74 7442 30 of of IN cord-015021-pol2qm74 7442 31 treatment treatment NN cord-015021-pol2qm74 7442 32 . . . cord-015021-pol2qm74 7443 1 Results result NNS cord-015021-pol2qm74 7443 2 : : : cord-015021-pol2qm74 7444 1 None none NN cord-015021-pol2qm74 7444 2 of of IN cord-015021-pol2qm74 7444 3 the the DT cord-015021-pol2qm74 7444 4 10 10 CD cord-015021-pol2qm74 7444 5 patients patient NNS cord-015021-pol2qm74 7444 6 developed develop VBD cord-015021-pol2qm74 7444 7 a a DT cord-015021-pol2qm74 7444 8 sepsis sepsis NN cord-015021-pol2qm74 7444 9 or or CC cord-015021-pol2qm74 7444 10 MOF MOF NNP cord-015021-pol2qm74 7444 11 later later RB cord-015021-pol2qm74 7444 12 on on RB cord-015021-pol2qm74 7444 13 and and CC cord-015021-pol2qm74 7444 14 no no DT cord-015021-pol2qm74 7444 15 patient patient NN cord-015021-pol2qm74 7444 16 died die VBD cord-015021-pol2qm74 7444 17 during during IN cord-015021-pol2qm74 7444 18 hospitalization hospitalization NN cord-015021-pol2qm74 7444 19 . . . cord-015021-pol2qm74 7445 1 Specific specific JJ cord-015021-pol2qm74 7445 2 postoperative postoperative JJ cord-015021-pol2qm74 7445 3 complications complication NNS cord-015021-pol2qm74 7445 4 occured occur VBD cord-015021-pol2qm74 7445 5 in in IN cord-015021-pol2qm74 7445 6 one one CD cord-015021-pol2qm74 7445 7 patient patient NN cord-015021-pol2qm74 7445 8 ~Jth ~Jth VBZ cord-015021-pol2qm74 7445 9 a a DT cord-015021-pol2qm74 7445 10 leekage leekage NN cord-015021-pol2qm74 7445 11 of of IN cord-015021-pol2qm74 7445 12 the the DT cord-015021-pol2qm74 7445 13 oesophagou oesophagou NN cord-015021-pol2qm74 7445 14 - - HYPH cord-015021-pol2qm74 7445 15 gastric gastric JJ cord-015021-pol2qm74 7445 16 anastomosis anastomosis NN cord-015021-pol2qm74 7445 17 after after IN cord-015021-pol2qm74 7445 18 oesophageus oesophageus NNP cord-015021-pol2qm74 7445 19 resection resection NN cord-015021-pol2qm74 7445 20 . . . cord-015021-pol2qm74 7446 1 At at IN cord-015021-pol2qm74 7446 2 study study NN cord-015021-pol2qm74 7446 3 entry entry NN cord-015021-pol2qm74 7446 4 the the DT cord-015021-pol2qm74 7446 5 leucocytes leucocyte NNS cord-015021-pol2qm74 7446 6 amounted amount VBD cord-015021-pol2qm74 7446 7 to to IN cord-015021-pol2qm74 7446 8 10.110 10.110 CD cord-015021-pol2qm74 7446 9 + + CD cord-015021-pol2qm74 7446 10 2.000/~tl 2.000/~tl CD cord-015021-pol2qm74 7447 1 ( ( -LRB- cord-015021-pol2qm74 7447 2 mean mean VB cord-015021-pol2qm74 7447 3 + + CC cord-015021-pol2qm74 7447 4 SEM SEM NNP cord-015021-pol2qm74 7447 5 ) ) -RRB- cord-015021-pol2qm74 7447 6 and and CC cord-015021-pol2qm74 7447 7 reached reach VBD cord-015021-pol2qm74 7447 8 a a DT cord-015021-pol2qm74 7447 9 level level NN cord-015021-pol2qm74 7447 10 of of IN cord-015021-pol2qm74 7447 11 29.280 29.280 CD cord-015021-pol2qm74 7448 1 + + CC cord-015021-pol2qm74 7449 1 _ _ NNP cord-015021-pol2qm74 7449 2 5.810 5.810 CD cord-015021-pol2qm74 7449 3 / / SYM cord-015021-pol2qm74 7449 4 tal tal NNP cord-015021-pol2qm74 7449 5 at at IN cord-015021-pol2qm74 7449 6 day day NN cord-015021-pol2qm74 7449 7 6 6 CD cord-015021-pol2qm74 7449 8 after after IN cord-015021-pol2qm74 7449 9 onset onset NN cord-015021-pol2qm74 7449 10 offilgrastim offilgrastim NNP cord-015021-pol2qm74 7449 11 therapy therapy NN cord-015021-pol2qm74 7449 12 . . . cord-015021-pol2qm74 7450 1 The the DT cord-015021-pol2qm74 7450 2 APACHE APACHE NNP cord-015021-pol2qm74 7450 3 II II NNP cord-015021-pol2qm74 7450 4 score score NN cord-015021-pol2qm74 7450 5 initally initally RB cord-015021-pol2qm74 7450 6 was be VBD cord-015021-pol2qm74 7450 7 14 14 CD cord-015021-pol2qm74 7450 8 + + SYM cord-015021-pol2qm74 7450 9 1.57 1.57 CD cord-015021-pol2qm74 7451 1 ( ( -LRB- cord-015021-pol2qm74 7451 2 mean mean VB cord-015021-pol2qm74 7451 3 + + CC cord-015021-pol2qm74 7451 4 SEM SEM NNP cord-015021-pol2qm74 7451 5 ) ) -RRB- cord-015021-pol2qm74 7451 6 and and CC cord-015021-pol2qm74 7451 7 as as IN cord-015021-pol2qm74 7451 8 an an DT cord-015021-pol2qm74 7451 9 indicator indicator NN cord-015021-pol2qm74 7451 10 of of IN cord-015021-pol2qm74 7451 11 filgrastim filgrastim NN cord-015021-pol2qm74 7451 12 response response NN cord-015021-pol2qm74 7451 13 a a DT cord-015021-pol2qm74 7451 14 decrease decrease NN cord-015021-pol2qm74 7451 15 of of IN cord-015021-pol2qm74 7451 16 5 5 CD cord-015021-pol2qm74 7451 17 points point NNS cord-015021-pol2qm74 7451 18 ~dthin ~dthin NFP cord-015021-pol2qm74 7452 1 4 4 CD cord-015021-pol2qm74 7452 2 days day NNS cord-015021-pol2qm74 7452 3 oceured oceure VBN cord-015021-pol2qm74 7452 4 in in IN cord-015021-pol2qm74 7452 5 7 7 CD cord-015021-pol2qm74 7452 6 out out RB cord-015021-pol2qm74 7452 7 ot ot NN cord-015021-pol2qm74 7452 8 10 10 CD cord-015021-pol2qm74 7452 9 patients patient NNS cord-015021-pol2qm74 7452 10 . . . cord-015021-pol2qm74 7453 1 Filgrastim Filgrastim NNP cord-015021-pol2qm74 7453 2 was be VBD cord-015021-pol2qm74 7453 3 well well RB cord-015021-pol2qm74 7453 4 tolerated tolerate VBN cord-015021-pol2qm74 7453 5 , , , cord-015021-pol2qm74 7453 6 side side NN cord-015021-pol2qm74 7453 7 effects effect NNS cord-015021-pol2qm74 7453 8 were be VBD cord-015021-pol2qm74 7453 9 not not RB cord-015021-pol2qm74 7453 10 noted note VBN cord-015021-pol2qm74 7453 11 . . . cord-015021-pol2qm74 7454 1 Growth growth NN cord-015021-pol2qm74 7454 2 of of IN cord-015021-pol2qm74 7454 3 solid solid JJ cord-015021-pol2qm74 7454 4 tumors tumor NNS cord-015021-pol2qm74 7454 5 might may MD cord-015021-pol2qm74 7454 6 be be VB cord-015021-pol2qm74 7454 7 modulated modulate VBN cord-015021-pol2qm74 7454 8 by by IN cord-015021-pol2qm74 7454 9 the the DT cord-015021-pol2qm74 7454 10 activity activity NN cord-015021-pol2qm74 7454 11 of of IN cord-015021-pol2qm74 7454 12 inflammatory inflammatory JJ cord-015021-pol2qm74 7454 13 and/or and/or CC cord-015021-pol2qm74 7454 14 immune immune JJ cord-015021-pol2qm74 7454 15 effector effector NN cord-015021-pol2qm74 7454 16 cells cell NNS cord-015021-pol2qm74 7454 17 of of IN cord-015021-pol2qm74 7454 18 undefined undefined JJ cord-015021-pol2qm74 7454 19 specificity specificity NN cord-015021-pol2qm74 7454 20 . . . cord-015021-pol2qm74 7455 1 In in IN cord-015021-pol2qm74 7455 2 this this DT cord-015021-pol2qm74 7455 3 study study NN cord-015021-pol2qm74 7455 4 patients patient NNS cord-015021-pol2qm74 7455 5 undergoing undergo VBG cord-015021-pol2qm74 7455 6 surgical surgical JJ cord-015021-pol2qm74 7455 7 treatment treatment NN cord-015021-pol2qm74 7455 8 for for IN cord-015021-pol2qm74 7455 9 gastric gastric JJ cord-015021-pol2qm74 7455 10 ( ( -LRB- cord-015021-pol2qm74 7456 1 n= n= NNP cord-015021-pol2qm74 7456 2 41 41 CD cord-015021-pol2qm74 7456 3 ) ) -RRB- cord-015021-pol2qm74 7456 4 or or CC cord-015021-pol2qm74 7456 5 colorectal colorectal JJ cord-015021-pol2qm74 7457 1 ( ( -LRB- cord-015021-pol2qm74 7457 2 n= n= NNP cord-015021-pol2qm74 7457 3 47 47 CD cord-015021-pol2qm74 7457 4 ) ) -RRB- cord-015021-pol2qm74 7457 5 cancers cancer NNS cord-015021-pol2qm74 7457 6 were be VBD cord-015021-pol2qm74 7457 7 evaluated evaluate VBN cord-015021-pol2qm74 7457 8 for for IN cord-015021-pol2qm74 7457 9 endogenous endogenous JJ cord-015021-pol2qm74 7457 10 serum serum NN cord-015021-pol2qm74 7457 11 levels level NNS cord-015021-pol2qm74 7457 12 of of IN cord-015021-pol2qm74 7457 13 granulocyte granulocyte NN cord-015021-pol2qm74 7457 14 colony colony NN cord-015021-pol2qm74 7457 15 - - HYPH cord-015021-pol2qm74 7457 16 stimulatingfactor stimulatingfactor NNP cord-015021-pol2qm74 7457 17 ( ( -LRB- cord-015021-pol2qm74 7457 18 G G NNP cord-015021-pol2qm74 7457 19 - - HYPH cord-015021-pol2qm74 7457 20 CSF CSF NNP cord-015021-pol2qm74 7457 21 ) ) -RRB- cord-015021-pol2qm74 7457 22 during during IN cord-015021-pol2qm74 7457 23 a a DT cord-015021-pol2qm74 7457 24 pre pre NN cord-015021-pol2qm74 7457 25 - - JJ cord-015021-pol2qm74 7457 26 and and CC cord-015021-pol2qm74 7457 27 postoperative postoperative JJ cord-015021-pol2qm74 7457 28 time time NN cord-015021-pol2qm74 7457 29 period period NN cord-015021-pol2qm74 7457 30 . . . cord-015021-pol2qm74 7458 1 From from IN cord-015021-pol2qm74 7458 2 the the DT cord-015021-pol2qm74 7458 3 same same JJ cord-015021-pol2qm74 7458 4 blood blood NN cord-015021-pol2qm74 7458 5 specimens specimen NNS cord-015021-pol2qm74 7458 6 mononuelcar mononuelcar NN cord-015021-pol2qm74 7458 7 cells cell NNS cord-015021-pol2qm74 7458 8 ( ( -LRB- cord-015021-pol2qm74 7458 9 MNC MNC NNP cord-015021-pol2qm74 7458 10 ) ) -RRB- cord-015021-pol2qm74 7458 11 were be VBD cord-015021-pol2qm74 7458 12 prepared prepare VBN cord-015021-pol2qm74 7458 13 . . . cord-015021-pol2qm74 7459 1 The the DT cord-015021-pol2qm74 7459 2 release release NN cord-015021-pol2qm74 7459 3 of of IN cord-015021-pol2qm74 7459 4 IFN-% IFN-% NNP cord-015021-pol2qm74 7459 5 , , , cord-015021-pol2qm74 7459 6 and and CC cord-015021-pol2qm74 7459 7 IL-2 IL-2 NNP cord-015021-pol2qm74 7459 8 , , , cord-015021-pol2qm74 7459 9 which which WDT cord-015021-pol2qm74 7459 10 are be VBP cord-015021-pol2qm74 7459 11 secreted secrete VBN cord-015021-pol2qm74 7459 12 by by IN cord-015021-pol2qm74 7459 13 Thl Thl NNP cord-015021-pol2qm74 7459 14 cells cell NNS cord-015021-pol2qm74 7459 15 , , , cord-015021-pol2qm74 7459 16 were be VBD cord-015021-pol2qm74 7459 17 stimulated stimulate VBN cord-015021-pol2qm74 7459 18 in in IN cord-015021-pol2qm74 7459 19 vitro vitro FW cord-015021-pol2qm74 7459 20 by by IN cord-015021-pol2qm74 7459 21 PHA PHA NNP cord-015021-pol2qm74 7459 22 during during IN cord-015021-pol2qm74 7459 23 a a DT cord-015021-pol2qm74 7459 24 cell cell NN cord-015021-pol2qm74 7459 25 culture culture NN cord-015021-pol2qm74 7459 26 period period NN cord-015021-pol2qm74 7459 27 up up IN cord-015021-pol2qm74 7459 28 to to TO cord-015021-pol2qm74 7459 29 48 48 CD cord-015021-pol2qm74 7459 30 hours hour NNS cord-015021-pol2qm74 7459 31 . . . cord-015021-pol2qm74 7460 1 The the DT cord-015021-pol2qm74 7460 2 patients patient NNS cord-015021-pol2qm74 7460 3 were be VBD cord-015021-pol2qm74 7460 4 further further RB cord-015021-pol2qm74 7460 5 classified classify VBN cord-015021-pol2qm74 7460 6 for for IN cord-015021-pol2qm74 7460 7 their -PRON- PRP$ cord-015021-pol2qm74 7460 8 immunreactivity immunreactivity NN cord-015021-pol2qm74 7460 9 by by IN cord-015021-pol2qm74 7460 10 responses response NNS cord-015021-pol2qm74 7460 11 in in IN cord-015021-pol2qm74 7460 12 DTH DTH NNP cord-015021-pol2qm74 7460 13 skin skin NN cord-015021-pol2qm74 7460 14 testing testing NN cord-015021-pol2qm74 7460 15 to to IN cord-015021-pol2qm74 7460 16 seven seven CD cord-015021-pol2qm74 7460 17 different different JJ cord-015021-pol2qm74 7460 18 antigens antigen NNS cord-015021-pol2qm74 7460 19 ( ( -LRB- cord-015021-pol2qm74 7460 20 e.g. e.g. RB cord-015021-pol2qm74 7460 21 tetanus tetanus JJ cord-015021-pol2qm74 7460 22 toxoid toxoid NN cord-015021-pol2qm74 7460 23 , , , cord-015021-pol2qm74 7460 24 PPD PPD NNP cord-015021-pol2qm74 7460 25 , , , cord-015021-pol2qm74 7460 26 diphtheria diphtheria NN cord-015021-pol2qm74 7460 27 toxin toxin NN cord-015021-pol2qm74 7460 28 , , , cord-015021-pol2qm74 7460 29 trichophyton trichophyton NN cord-015021-pol2qm74 7460 30 , , , cord-015021-pol2qm74 7460 31 streptococcus streptococcus NN cord-015021-pol2qm74 7460 32 , , , cord-015021-pol2qm74 7460 33 candida candida NN cord-015021-pol2qm74 7460 34 and and CC cord-015021-pol2qm74 7460 35 proteus proteus NNP cord-015021-pol2qm74 7460 36 antigens antigen NNS cord-015021-pol2qm74 7460 37 ) ) -RRB- cord-015021-pol2qm74 7460 38 . . . cord-015021-pol2qm74 7461 1 DTH DTH NNP cord-015021-pol2qm74 7461 2 testing testing NN cord-015021-pol2qm74 7461 3 has have VBZ cord-015021-pol2qm74 7461 4 been be VBN cord-015021-pol2qm74 7461 5 repeated repeat VBN cord-015021-pol2qm74 7461 6 in in IN cord-015021-pol2qm74 7461 7 each each DT cord-015021-pol2qm74 7461 8 patient patient JJ cord-015021-pol2qm74 7461 9 Two two CD cord-015021-pol2qm74 7461 10 remarkable remarkable JJ cord-015021-pol2qm74 7461 11 results result NNS cord-015021-pol2qm74 7461 12 were be VBD cord-015021-pol2qm74 7461 13 obtained obtain VBN cord-015021-pol2qm74 7461 14 . . . cord-015021-pol2qm74 7462 1 The the DT cord-015021-pol2qm74 7462 2 serum serum NN cord-015021-pol2qm74 7462 3 levels level NNS cord-015021-pol2qm74 7462 4 of of IN cord-015021-pol2qm74 7462 5 endogenous endogenous JJ cord-015021-pol2qm74 7462 6 G G NNP cord-015021-pol2qm74 7462 7 - - HYPH cord-015021-pol2qm74 7462 8 CSE CSE NNP cord-015021-pol2qm74 7462 9 showed show VBD cord-015021-pol2qm74 7462 10 a a DT cord-015021-pol2qm74 7462 11 biphasic biphasic JJ cord-015021-pol2qm74 7462 12 increase increase NN cord-015021-pol2qm74 7462 13 with with IN cord-015021-pol2qm74 7462 14 maximum maximum JJ cord-015021-pol2qm74 7462 15 values value NNS cord-015021-pol2qm74 7462 16 of of IN cord-015021-pol2qm74 7462 17 900 900 CD cord-015021-pol2qm74 7462 18 pg pg NN cord-015021-pol2qm74 7462 19 / / SYM cord-015021-pol2qm74 7462 20 ml ml NN cord-015021-pol2qm74 7462 21 ( ( -LRB- cord-015021-pol2qm74 7462 22 preoperative preoperative JJ cord-015021-pol2qm74 7462 23 < < XX cord-015021-pol2qm74 7462 24 70 70 CD cord-015021-pol2qm74 7462 25 pg pg NN cord-015021-pol2qm74 7462 26 / / SYM cord-015021-pol2qm74 7462 27 ml ml NNP cord-015021-pol2qm74 7462 28 ) ) -RRB- cord-015021-pol2qm74 7462 29 on on IN cord-015021-pol2qm74 7462 30 day day NN cord-015021-pol2qm74 7462 31 1 1 CD cord-015021-pol2qm74 7462 32 and and CC cord-015021-pol2qm74 7462 33 day day NN cord-015021-pol2qm74 7462 34 3 3 CD cord-015021-pol2qm74 7462 35 to to IN cord-015021-pol2qm74 7462 36 5 5 CD cord-015021-pol2qm74 7462 37 after after IN cord-015021-pol2qm74 7462 38 surgical surgical JJ cord-015021-pol2qm74 7462 39 treatment treatment NN cord-015021-pol2qm74 7462 40 . . . cord-015021-pol2qm74 7463 1 Similar similar JJ cord-015021-pol2qm74 7463 2 patterns pattern NNS cord-015021-pol2qm74 7463 3 of of IN cord-015021-pol2qm74 7463 4 G G NNP cord-015021-pol2qm74 7463 5 - - HYPH cord-015021-pol2qm74 7463 6 CSF csf NN cord-015021-pol2qm74 7463 7 production production NN cord-015021-pol2qm74 7463 8 were be VBD cord-015021-pol2qm74 7463 9 found find VBN cord-015021-pol2qm74 7463 10 in in IN cord-015021-pol2qm74 7463 11 both both DT cord-015021-pol2qm74 7463 12 groups group NNS cord-015021-pol2qm74 7463 13 of of IN cord-015021-pol2qm74 7463 14 patients patient NNS cord-015021-pol2qm74 7463 15 with with IN cord-015021-pol2qm74 7463 16 gastric gastric JJ cord-015021-pol2qm74 7463 17 or or CC cord-015021-pol2qm74 7463 18 colorectal colorectal JJ cord-015021-pol2qm74 7463 19 cancers cancer NNS cord-015021-pol2qm74 7463 20 . . . cord-015021-pol2qm74 7464 1 High high JJ cord-015021-pol2qm74 7464 2 serum serum NN cord-015021-pol2qm74 7464 3 levels level NNS cord-015021-pol2qm74 7464 4 of of IN cord-015021-pol2qm74 7464 5 G G NNP cord-015021-pol2qm74 7464 6 - - HYPH cord-015021-pol2qm74 7464 7 CSF CSF NNP cord-015021-pol2qm74 7464 8 were be VBD cord-015021-pol2qm74 7464 9 significantly significantly RB cord-015021-pol2qm74 7464 10 ( ( -LRB- cord-015021-pol2qm74 7464 11 p p NN cord-015021-pol2qm74 7464 12 < < XX cord-015021-pol2qm74 7464 13 0,01 0,01 NN cord-015021-pol2qm74 7464 14 ) ) -RRB- cord-015021-pol2qm74 7464 15 correlated correlate VBN cord-015021-pol2qm74 7464 16 with with IN cord-015021-pol2qm74 7464 17 infectious infectious JJ cord-015021-pol2qm74 7464 18 complications complication NNS cord-015021-pol2qm74 7464 19 in in IN cord-015021-pol2qm74 7464 20 patients patient NNS cord-015021-pol2qm74 7464 21 whh whh VBG cord-015021-pol2qm74 7464 22 gastric gastric JJ cord-015021-pol2qm74 7464 23 cancer cancer NN cord-015021-pol2qm74 7464 24 ( ( -LRB- cord-015021-pol2qm74 7464 25 n= n= NNP cord-015021-pol2qm74 7464 26 17/22 17/22 CD cord-015021-pol2qm74 7464 27 ) ) -RRB- cord-015021-pol2qm74 7464 28 . . . cord-015021-pol2qm74 7465 1 Secondly secondly RB cord-015021-pol2qm74 7465 2 patients patient NNS cord-015021-pol2qm74 7465 3 could could MD cord-015021-pol2qm74 7465 4 be be VB cord-015021-pol2qm74 7465 5 arranged arrange VBN cord-015021-pol2qm74 7465 6 into into IN cord-015021-pol2qm74 7465 7 two two CD cord-015021-pol2qm74 7465 8 groups group NNS cord-015021-pol2qm74 7465 9 according accord VBG cord-015021-pol2qm74 7465 10 to to IN cord-015021-pol2qm74 7465 11 an an DT cord-015021-pol2qm74 7465 12 anergic anergic NN cord-015021-pol2qm74 7466 1 ( ( -LRB- cord-015021-pol2qm74 7466 2 n= n= NNP cord-015021-pol2qm74 7466 3 25 25 CD cord-015021-pol2qm74 7466 4 ) ) -RRB- cord-015021-pol2qm74 7466 5 or or CC cord-015021-pol2qm74 7467 1 normergi¢ normergi¢ NNP cord-015021-pol2qm74 7467 2 ( ( -LRB- cord-015021-pol2qm74 7467 3 n n NN cord-015021-pol2qm74 7467 4 = = SYM cord-015021-pol2qm74 7467 5 63 63 CD cord-015021-pol2qm74 7467 6 ) ) -RRB- cord-015021-pol2qm74 7467 7 responsiveness responsiveness NN cord-015021-pol2qm74 7467 8 in in IN cord-015021-pol2qm74 7467 9 DTH DTH NNP cord-015021-pol2qm74 7467 10 testing testing NN cord-015021-pol2qm74 7467 11 . . . cord-015021-pol2qm74 7468 1 The the DT cord-015021-pol2qm74 7468 2 frequency frequency NN cord-015021-pol2qm74 7468 3 of of IN cord-015021-pol2qm74 7468 4 anergi¢ anergi¢ NN cord-015021-pol2qm74 7468 5 responsiveness responsiveness NN cord-015021-pol2qm74 7468 6 was be VBD cord-015021-pol2qm74 7468 7 similar similar JJ cord-015021-pol2qm74 7468 8 in in IN cord-015021-pol2qm74 7468 9 both both DT cord-015021-pol2qm74 7468 10 patients patient NNS cord-015021-pol2qm74 7468 11 with with IN cord-015021-pol2qm74 7468 12 gastric gastric JJ cord-015021-pol2qm74 7468 13 ( ( -LRB- cord-015021-pol2qm74 7468 14 n= n= NNP cord-015021-pol2qm74 7468 15 11/41 11/41 CD cord-015021-pol2qm74 7468 16 ) ) -RRB- cord-015021-pol2qm74 7468 17 or or CC cord-015021-pol2qm74 7468 18 colorectal colorectal JJ cord-015021-pol2qm74 7469 1 ( ( -LRB- cord-015021-pol2qm74 7469 2 n= n= NNP cord-015021-pol2qm74 7469 3 14/47 14/47 CD cord-015021-pol2qm74 7469 4 ) ) -RRB- cord-015021-pol2qm74 7469 5 cancers cancer NNS cord-015021-pol2qm74 7469 6 . . . cord-015021-pol2qm74 7470 1 Interestingly interestingly RB cord-015021-pol2qm74 7470 2 we -PRON- PRP cord-015021-pol2qm74 7470 3 found find VBD cord-015021-pol2qm74 7470 4 a a DT cord-015021-pol2qm74 7470 5 significant significant JJ cord-015021-pol2qm74 7470 6 correlation correlation NN cord-015021-pol2qm74 7470 7 ( ( -LRB- cord-015021-pol2qm74 7470 8 p p NN cord-015021-pol2qm74 7470 9 < < XX cord-015021-pol2qm74 7470 10 0,01 0,01 XX cord-015021-pol2qm74 7470 11 ) ) -RRB- cord-015021-pol2qm74 7470 12 between between IN cord-015021-pol2qm74 7470 13 low low JJ cord-015021-pol2qm74 7470 14 serum serum NN cord-015021-pol2qm74 7470 15 levels level NNS cord-015021-pol2qm74 7470 16 of of IN cord-015021-pol2qm74 7470 17 G G NNP cord-015021-pol2qm74 7470 18 - - HYPH cord-015021-pol2qm74 7470 19 CSF CSF NNP cord-015021-pol2qm74 7470 20 and and CC cord-015021-pol2qm74 7470 21 anergy anergy NNP cord-015021-pol2qm74 7470 22 during during IN cord-015021-pol2qm74 7470 23 the the DT cord-015021-pol2qm74 7470 24 postoperative postoperative JJ cord-015021-pol2qm74 7470 25 period period NN cord-015021-pol2qm74 7470 26 in in IN cord-015021-pol2qm74 7470 27 both both DT cord-015021-pol2qm74 7470 28 groups group NNS cord-015021-pol2qm74 7470 29 . . . cord-015021-pol2qm74 7471 1 Stimulation stimulation NN cord-015021-pol2qm74 7471 2 of of IN cord-015021-pol2qm74 7471 3 MNCs mnc NNS cord-015021-pol2qm74 7471 4 from from IN cord-015021-pol2qm74 7471 5 anergic anergic NN cord-015021-pol2qm74 7471 6 patients patient NNS cord-015021-pol2qm74 7471 7 ( ( -LRB- cord-015021-pol2qm74 7471 8 n= n= NNP cord-015021-pol2qm74 7471 9 30 30 CD cord-015021-pol2qm74 7471 10 ) ) -RRB- cord-015021-pol2qm74 7471 11 within within IN cord-015021-pol2qm74 7471 12 the the DT cord-015021-pol2qm74 7471 13 pre pre NN cord-015021-pol2qm74 7471 14 - - JJ cord-015021-pol2qm74 7471 15 and and CC cord-015021-pol2qm74 7471 16 postoperative postoperative JJ cord-015021-pol2qm74 7471 17 period period NN cord-015021-pol2qm74 7471 18 resulted result VBD cord-015021-pol2qm74 7471 19 in in IN cord-015021-pol2qm74 7471 20 reduced reduce VBN cord-015021-pol2qm74 7471 21 mean mean JJ cord-015021-pol2qm74 7471 22 values value NNS cord-015021-pol2qm74 7471 23 ( ( -LRB- cord-015021-pol2qm74 7471 24 about about RB cord-015021-pol2qm74 7471 25 50 50 CD cord-015021-pol2qm74 7471 26 % % NN cord-015021-pol2qm74 7471 27 ) ) -RRB- cord-015021-pol2qm74 7471 28 for for IN cord-015021-pol2qm74 7471 29 IFN IFN NNP cord-015021-pol2qm74 7471 30 - - HYPH cord-015021-pol2qm74 7471 31 ff ff NNP cord-015021-pol2qm74 7471 32 release release NN cord-015021-pol2qm74 7471 33 ( ( -LRB- cord-015021-pol2qm74 7471 34 preoperative preoperative JJ cord-015021-pol2qm74 7471 35 means mean NNS cord-015021-pol2qm74 7471 36 llO0 llO0 NNP cord-015021-pol2qm74 7471 37 pg pg NNP cord-015021-pol2qm74 7471 38 / / SYM cord-015021-pol2qm74 7471 39 nfl nfl NNP cord-015021-pol2qm74 7471 40 ) ) -RRB- cord-015021-pol2qm74 7471 41 , , , cord-015021-pol2qm74 7471 42 if if IN cord-015021-pol2qm74 7471 43 compared compare VBN cord-015021-pol2qm74 7471 44 to to IN cord-015021-pol2qm74 7471 45 patients patient NNS cord-015021-pol2qm74 7471 46 with with IN cord-015021-pol2qm74 7471 47 normergic normergic NNP cord-015021-pol2qm74 7471 48 DTH DTH NNP cord-015021-pol2qm74 7471 49 ( ( -LRB- cord-015021-pol2qm74 7471 50 n= n= NNP cord-015021-pol2qm74 7471 51 63 63 CD cord-015021-pol2qm74 7471 52 , , , cord-015021-pol2qm74 7471 53 preoperative preoperative JJ cord-015021-pol2qm74 7471 54 means mean NNS cord-015021-pol2qm74 7471 55 1960 1960 CD cord-015021-pol2qm74 7471 56 pg pg NNP cord-015021-pol2qm74 7471 57 / / SYM cord-015021-pol2qm74 7471 58 ml ml NNP cord-015021-pol2qm74 7471 59 ) ) -RRB- cord-015021-pol2qm74 7471 60 . . . cord-015021-pol2qm74 7472 1 Similar similar JJ cord-015021-pol2qm74 7472 2 , , , cord-015021-pol2qm74 7472 3 but but CC cord-015021-pol2qm74 7472 4 less less RBR cord-015021-pol2qm74 7472 5 significant significant JJ cord-015021-pol2qm74 7472 6 results result NNS cord-015021-pol2qm74 7472 7 were be VBD cord-015021-pol2qm74 7472 8 obtained obtain VBN cord-015021-pol2qm74 7472 9 for for IN cord-015021-pol2qm74 7472 10 IL-2 il-2 NN cord-015021-pol2qm74 7472 11 secretion secretion NN cord-015021-pol2qm74 7472 12 . . . cord-015021-pol2qm74 7473 1 Our -PRON- PRP$ cord-015021-pol2qm74 7473 2 results result NNS cord-015021-pol2qm74 7473 3 confirm confirm VBP cord-015021-pol2qm74 7473 4 a a DT cord-015021-pol2qm74 7473 5 correlation correlation NN cord-015021-pol2qm74 7473 6 between between IN cord-015021-pol2qm74 7473 7 infectious infectious JJ cord-015021-pol2qm74 7473 8 complications complication NNS cord-015021-pol2qm74 7473 9 and and CC cord-015021-pol2qm74 7473 10 G G NNP cord-015021-pol2qm74 7473 11 - - HYPH cord-015021-pol2qm74 7473 12 CSF CSF NNP cord-015021-pol2qm74 7473 13 in in IN cord-015021-pol2qm74 7473 14 the the DT cord-015021-pol2qm74 7473 15 postoperative postoperative JJ cord-015021-pol2qm74 7473 16 period period NN cord-015021-pol2qm74 7473 17 , , , cord-015021-pol2qm74 7473 18 however however RB cord-015021-pol2qm74 7473 19 elevated elevated JJ cord-015021-pol2qm74 7473 20 levels level NNS cord-015021-pol2qm74 7473 21 were be VBD cord-015021-pol2qm74 7473 22 also also RB cord-015021-pol2qm74 7473 23 found find VBN cord-015021-pol2qm74 7473 24 in in IN cord-015021-pol2qm74 7473 25 some some DT cord-015021-pol2qm74 7473 26 patients patient NNS cord-015021-pol2qm74 7473 27 without without IN cord-015021-pol2qm74 7473 28 any any DT cord-015021-pol2qm74 7473 29 signs sign NNS cord-015021-pol2qm74 7473 30 of of IN cord-015021-pol2qm74 7473 31 infections infection NNS cord-015021-pol2qm74 7473 32 . . . cord-015021-pol2qm74 7474 1 More more RBR cord-015021-pol2qm74 7474 2 interestingly interestingly RB cord-015021-pol2qm74 7474 3 there there EX cord-015021-pol2qm74 7474 4 might may MD cord-015021-pol2qm74 7474 5 be be VB cord-015021-pol2qm74 7474 6 an an DT cord-015021-pol2qm74 7474 7 association association NN cord-015021-pol2qm74 7474 8 between between IN cord-015021-pol2qm74 7474 9 cytokine cytokine NN cord-015021-pol2qm74 7474 10 ( ( -LRB- cord-015021-pol2qm74 7474 11 C C NNP cord-015021-pol2qm74 7474 12 ~ ~ NFP cord-015021-pol2qm74 7474 13 CSF CSF NNP cord-015021-pol2qm74 7474 14 , , , cord-015021-pol2qm74 7474 15 IFN-% IFN-% NNP cord-015021-pol2qm74 7474 16 and and CC cord-015021-pol2qm74 7474 17 IL-2 IL-2 NNP cord-015021-pol2qm74 7474 18 ) ) -RRB- cord-015021-pol2qm74 7474 19 release release VBP cord-015021-pol2qm74 7474 20 and and CC cord-015021-pol2qm74 7474 21 DTH DTH NNP cord-015021-pol2qm74 7474 22 , , , cord-015021-pol2qm74 7474 23 which which WDT cord-015021-pol2qm74 7474 24 is be VBZ cord-015021-pol2qm74 7474 25 known know VBN cord-015021-pol2qm74 7474 26 to to TO cord-015021-pol2qm74 7474 27 be be VB cord-015021-pol2qm74 7474 28 mediated mediate VBN cord-015021-pol2qm74 7474 29 by by IN cord-015021-pol2qm74 7474 30 activated activate VBN cord-015021-pol2qm74 7474 31 Thl Thl NNP cord-015021-pol2qm74 7474 32 calls call VBZ cord-015021-pol2qm74 7474 33 . . . cord-015021-pol2qm74 7475 1 To to TO cord-015021-pol2qm74 7475 2 recognize recognize VB cord-015021-pol2qm74 7475 3 anergic anergic NN cord-015021-pol2qm74 7475 4 DTH DTH NNP cord-015021-pol2qm74 7475 5 as as IN cord-015021-pol2qm74 7475 6 a a DT cord-015021-pol2qm74 7475 7 possible possible JJ cord-015021-pol2qm74 7475 8 higher high JJR cord-015021-pol2qm74 7475 9 risk risk NN cord-015021-pol2qm74 7475 10 in in IN cord-015021-pol2qm74 7475 11 the the DT cord-015021-pol2qm74 7475 12 postoperative postoperative JJ cord-015021-pol2qm74 7475 13 outcome outcome NN cord-015021-pol2qm74 7475 14 of of IN cord-015021-pol2qm74 7475 15 cancer cancer NN cord-015021-pol2qm74 7475 16 patients patient NNS cord-015021-pol2qm74 7475 17 extended extend VBN cord-015021-pol2qm74 7475 18 periods period NNS cord-015021-pol2qm74 7475 19 of of IN cord-015021-pol2qm74 7475 20 observation observation NN cord-015021-pol2qm74 7475 21 are be VBP cord-015021-pol2qm74 7475 22 needed need VBN cord-015021-pol2qm74 7475 23 . . . cord-015021-pol2qm74 7476 1 Objectives objective NNS cord-015021-pol2qm74 7476 2 of of IN cord-015021-pol2qm74 7476 3 the the DT cord-015021-pol2qm74 7476 4 study study NN cord-015021-pol2qm74 7476 5 Effects effect NNS cord-015021-pol2qm74 7476 6 of of IN cord-015021-pol2qm74 7476 7 recombinant recombinant JJ cord-015021-pol2qm74 7476 8 huraan huraan NN cord-015021-pol2qm74 7476 9 granulocyte granulocyte NN cord-015021-pol2qm74 7476 10 colony colony NN cord-015021-pol2qm74 7476 11 - - HYPH cord-015021-pol2qm74 7476 12 stimulating stimulate VBG cord-015021-pol2qm74 7476 13 factor(rhC factor(rhc NN cord-015021-pol2qm74 7476 14 - - HYPH cord-015021-pol2qm74 7476 15 CSF)a csf)a JJ cord-015021-pol2qm74 7476 16 galnst galnst NN cord-015021-pol2qm74 7476 17 severe severe JJ cord-015021-pol2qm74 7476 18 septic septic JJ cord-015021-pol2qm74 7476 19 infections infection NNS cord-015021-pol2qm74 7476 20 were be VBD cord-015021-pol2qm74 7476 21 investigated investigate VBN cord-015021-pol2qm74 7476 22 by by IN cord-015021-pol2qm74 7476 23 its -PRON- PRP$ cord-015021-pol2qm74 7476 24 single single JJ cord-015021-pol2qm74 7476 25 use use NN cord-015021-pol2qm74 7476 26 or or CC cord-015021-pol2qm74 7476 27 by by IN cord-015021-pol2qm74 7476 28 its -PRON- PRP$ cord-015021-pol2qm74 7476 29 corn corn NN cord-015021-pol2qm74 7476 30 b{nation b{nation NN cord-015021-pol2qm74 7476 31 with with IN cord-015021-pol2qm74 7476 32 cephera cephera NNP cord-015021-pol2qm74 7476 33 antibiotlcs antibiotlcs NNP cord-015021-pol2qm74 7476 34 . . . cord-015021-pol2qm74 7477 1 We -PRON- PRP cord-015021-pol2qm74 7477 2 examined examine VBD cord-015021-pol2qm74 7477 3 its -PRON- PRP$ cord-015021-pol2qm74 7477 4 effects effect NNS cord-015021-pol2qm74 7477 5 on on IN cord-015021-pol2qm74 7477 6 the the DT cord-015021-pol2qm74 7477 7 mortality mortality NN cord-015021-pol2qm74 7477 8 , , , cord-015021-pol2qm74 7477 9 and and CC cord-015021-pol2qm74 7477 10 circulating circulate VBG cord-015021-pol2qm74 7477 11 blood blood NN cord-015021-pol2qm74 7477 12 neutrophyis neutrophyis NNP cord-015021-pol2qm74 7477 13 counts count VBZ cord-015021-pol2qm74 7477 14 and and CC cord-015021-pol2qm74 7477 15 functlons functlon NNS cord-015021-pol2qm74 7477 16 , , , cord-015021-pol2qm74 7477 17 such such JJ cord-015021-pol2qm74 7477 18 as as IN cord-015021-pol2qm74 7477 19 phagocytic phagocytic JJ cord-015021-pol2qm74 7477 20 activity activity NN cord-015021-pol2qm74 7477 21 and and CC cord-015021-pol2qm74 7477 22 H h NN cord-015021-pol2qm74 7477 23 2 2 CD cord-015021-pol2qm74 7477 24 02 02 CD cord-015021-pol2qm74 7477 25 production production NN cord-015021-pol2qm74 7477 26 using use VBG cord-015021-pol2qm74 7477 27 the the DT cord-015021-pol2qm74 7477 28 rat rat NN cord-015021-pol2qm74 7477 29 severe severe JJ cord-015021-pol2qm74 7477 30 septic septic JJ cord-015021-pol2qm74 7477 31 model model NN cord-015021-pol2qm74 7477 32 . . . cord-015021-pol2qm74 7478 1 Rats rat NNS cord-015021-pol2qm74 7478 2 were be VBD cord-015021-pol2qm74 7478 3 subcutaneously subcutaneously RB cord-015021-pol2qm74 7478 4 administsrd administsrd NNP cord-015021-pol2qm74 7478 5 rhC~ rhC~ NNP cord-015021-pol2qm74 7479 1 CSF(S0orl0O CSF(S0orl0O NNP cord-015021-pol2qm74 7479 2 ~ ~ NFP cord-015021-pol2qm74 7479 3 g g NN cord-015021-pol2qm74 7479 4 / / SYM cord-015021-pol2qm74 7479 5 k~ k~ CD cord-015021-pol2qm74 7479 6 body body NN cord-015021-pol2qm74 7479 7 wt)after wt)after NN cord-015021-pol2qm74 7479 8 on on IN cord-015021-pol2qm74 7479 9 set set NN cord-015021-pol2qm74 7479 10 of of IN cord-015021-pol2qm74 7479 11 peritonitis peritonitis NN cord-015021-pol2qm74 7479 12 brought bring VBN cord-015021-pol2qm74 7479 13 about about RP cord-015021-pol2qm74 7479 14 by by IN cord-015021-pol2qm74 7479 15 cecal cecal NN cord-015021-pol2qm74 7479 16 ] ] -RRB- cord-015021-pol2qm74 7479 17 igation igation NN cord-015021-pol2qm74 7479 18 and and CC cord-015021-pol2qm74 7479 19 one one CD cord-015021-pol2qm74 7479 20 puncture puncture NN cord-015021-pol2qm74 7480 1 withe2-gaug withe2-gaug IN cord-015021-pol2qm74 7480 2 e e DT cord-015021-pol2qm74 7480 3 needle needle NN cord-015021-pol2qm74 7480 4 once once RB cord-015021-pol2qm74 7480 5 a a DT cord-015021-pol2qm74 7480 6 day day NN cord-015021-pol2qm74 7480 7 for for IN cord-015021-pol2qm74 7480 8 three three CD cord-015021-pol2qm74 7480 9 days.in days.in NNP cord-015021-pol2qm74 7480 10 addJtlon addjtlon NN cord-015021-pol2qm74 7481 1 , , , cord-015021-pol2qm74 7481 2 cefmetazol cefmetazol NNP cord-015021-pol2qm74 7481 3 Na(CMZ)(50m$/k9 Na(CMZ)(50m$/k9 NNP cord-015021-pol2qm74 7481 4 bo bo NNP cord-015021-pol2qm74 7481 5 dy dy NNP cord-015021-pol2qm74 7481 6 wt)was wt)was NNP cord-015021-pol2qm74 7481 7 injected inject VBD cord-015021-pol2qm74 7481 8 intrarnustularly intrarnustularly RB cord-015021-pol2qm74 7481 9 to to IN cord-015021-pol2qm74 7481 10 the the DT cord-015021-pol2qm74 7481 11 rats rat NNS cord-015021-pol2qm74 7481 12 tv tv NN cord-015021-pol2qm74 7481 13 ~ ~ NFP cord-015021-pol2qm74 7481 14 ce ce NNP cord-015021-pol2qm74 7481 15 a a DT cord-015021-pol2qm74 7481 16 day day NN cord-015021-pol2qm74 7481 17 for for IN cord-015021-pol2qm74 7481 18 three three CD cord-015021-pol2qm74 7481 19 days day NNS cord-015021-pol2qm74 7481 20 . . . cord-015021-pol2qm74 7482 1 Cirehlatlng Cirehlatlng NNP cord-015021-pol2qm74 7482 2 blood blood NN cord-015021-pol2qm74 7482 3 neutrophyls neutrophyls NN cord-015021-pol2qm74 7482 4 counts count NNS cord-015021-pol2qm74 7482 5 were be VBD cord-015021-pol2qm74 7482 6 determoned determone VBN cord-015021-pol2qm74 7482 7 electronically electronically RB cord-015021-pol2qm74 7482 8 with with IN cord-015021-pol2qm74 7482 9 a a DT cord-015021-pol2qm74 7482 10 hem hem NNP cord-015021-pol2qm74 7482 11 ocytometer ocytometer NNP cord-015021-pol2qm74 7482 12 , , , cord-015021-pol2qm74 7482 13 and and CC cord-015021-pol2qm74 7482 14 blood blood NN cord-015021-pol2qm74 7482 15 smears smear NNS cord-015021-pol2qm74 7482 16 stained stain VBN cord-015021-pol2qm74 7482 17 with with IN cord-015021-pol2qm74 7482 18 May May NNP cord-015021-pol2qm74 7482 19 ~ ~ NNP cord-015021-pol2qm74 7482 20 runwaldM.qlemsa runwaldM.qlemsa NNP cord-015021-pol2qm74 7482 21 ~ ~ CD cord-015021-pol2qm74 7482 22 taln taln NNS cord-015021-pol2qm74 7482 23 . . . cord-015021-pol2qm74 7483 1 Neutrophyls Neutrophyls NNP cord-015021-pol2qm74 7483 2 functions function NNS cord-015021-pol2qm74 7483 3 in in IN cord-015021-pol2qm74 7483 4 vltro vltro NNP cord-015021-pol2qm74 7483 5 , , , cord-015021-pol2qm74 7483 6 such such JJ cord-015021-pol2qm74 7483 7 as as IN cord-015021-pol2qm74 7483 8 phagocytic phagocytic JJ cord-015021-pol2qm74 7483 9 activity activity NN cord-015021-pol2qm74 7483 10 and and CC cord-015021-pol2qm74 7483 11 H H NNP cord-015021-pol2qm74 7483 12 20 20 CD cord-015021-pol2qm74 7483 13 2 2 CD cord-015021-pol2qm74 7483 14 producti producti NN cord-015021-pol2qm74 7483 15 on on IN cord-015021-pol2qm74 7483 16 using use VBG cord-015021-pol2qm74 7483 17 the the DT cord-015021-pol2qm74 7483 18 rat rat NN cord-015021-pol2qm74 7483 19 severe severe JJ cord-015021-pol2qm74 7483 20 septic septic JJ cord-015021-pol2qm74 7483 21 model model NN cord-015021-pol2qm74 7483 22 was be VBD cord-015021-pol2qm74 7483 23 analyzvd analyzvd NNP cord-015021-pol2qm74 7483 24 by by IN cord-015021-pol2qm74 7483 25 automated automate VBN cord-015021-pol2qm74 7483 26 flow flow NN cord-015021-pol2qm74 7483 27 cytometri cytometri NNP cord-015021-pol2qm74 7483 28 c c NNP cord-015021-pol2qm74 7483 29 single single JJ cord-015021-pol2qm74 7483 30 cell cell NN cord-015021-pol2qm74 7483 31 - - HYPH cord-015021-pol2qm74 7483 32 analysis analysis NN cord-015021-pol2qm74 7483 33 methods method NNS cord-015021-pol2qm74 7483 34 . . . cord-015021-pol2qm74 7484 1 The the DT cord-015021-pol2qm74 7484 2 reortallty reortallty NN cord-015021-pol2qm74 7484 3 rate rate NN cord-015021-pol2qm74 7484 4 after after IN cord-015021-pol2qm74 7484 5 2 2 CD cord-015021-pol2qm74 7484 6 weeks week NNS cord-015021-pol2qm74 7484 7 was be VBD cord-015021-pol2qm74 7484 8 significantly significantly RB cord-015021-pol2qm74 7484 9 decreased decrease VBN cord-015021-pol2qm74 7484 10 by by IN cord-015021-pol2qm74 7484 11 administratlon administratlon NN cord-015021-pol2qm74 7484 12 of of IN cord-015021-pol2qm74 7484 13 rh~-CSF(p<0,01).ln rh~-CSF(p<0,01).ln NNP cord-015021-pol2qm74 7484 14 addJtion addJtion NNP cord-015021-pol2qm74 7484 15 , , , cord-015021-pol2qm74 7484 16 a a DT cord-015021-pol2qm74 7484 17 combination combination NN cord-015021-pol2qm74 7484 18 therapy therapy NN cord-015021-pol2qm74 7484 19 of of IN cord-015021-pol2qm74 7484 20 rhG rhG NNP cord-015021-pol2qm74 7484 21 - - HYPH cord-015021-pol2qm74 7484 22 CSF CSF NNP cord-015021-pol2qm74 7484 23 wlte wlte NNP cord-015021-pol2qm74 7484 24 cephern cephern NNP cord-015021-pol2qm74 7484 25 ant ant NNP cord-015021-pol2qm74 7485 1 ~biotics(CMZ)showed ~biotics(CMZ)showed NFP cord-015021-pol2qm74 7485 2 a a DT cord-015021-pol2qm74 7485 3 significantly significantly RB cord-015021-pol2qm74 7485 4 survive survive VBP cord-015021-pol2qm74 7485 5 ] ] -RRB- cord-015021-pol2qm74 7485 6 advantage advantage NN cord-015021-pol2qm74 7485 7 and and CC cord-015021-pol2qm74 7486 1 the the DT cord-015021-pol2qm74 7486 2 rate rate NN cord-015021-pol2qm74 7486 3 had have VBD cord-015021-pol2qm74 7486 4 b b NN cord-015021-pol2qm74 7486 5 een een NN cord-015021-pol2qm74 7486 6 reached reach VBD cord-015021-pol2qm74 7486 7 57.1 57.1 CD cord-015021-pol2qm74 7486 8 % % NN cord-015021-pol2qm74 7486 9 . . . cord-015021-pol2qm74 7487 1 Nextly nextly RB cord-015021-pol2qm74 7487 2 , , , cord-015021-pol2qm74 7487 3 treatn%ent treatn%ent CD cord-015021-pol2qm74 7487 4 wlth wlth NN cord-015021-pol2qm74 7487 5 rhG rhG NNP cord-015021-pol2qm74 7487 6 - - HYPH cord-015021-pol2qm74 7487 7 CSF(S0 CSF(S0 NNP cord-015021-pol2qm74 7487 8 ~ ~ NFP cord-015021-pol2qm74 7487 9 $ $ $ cord-015021-pol2qm74 7487 10 /k9 /k9 NN cord-015021-pol2qm74 7487 11 body body NN cord-015021-pol2qm74 7488 1 wt)increased wt)increase VBD cord-015021-pol2qm74 7488 2 the the DT cord-015021-pol2qm74 7488 3 nuzaber nuzaber NNP cord-015021-pol2qm74 7488 4 of of IN cord-015021-pol2qm74 7488 5 the the DT cord-015021-pol2qm74 7488 6 peripheral peripheral JJ cord-015021-pol2qm74 7488 7 blood blood NN cord-015021-pol2qm74 7488 8 neutrophJls neutrophjl NNS cord-015021-pol2qm74 7488 9 slgn[fieantly(p<0.01 slgn[fieantly(p<0.01 NN cord-015021-pol2qm74 7488 10 ) ) -RRB- cord-015021-pol2qm74 7488 11 . . . cord-015021-pol2qm74 7489 1 iV iv LS cord-015021-pol2qm74 7490 1 ~oreover ~oreover NNP cord-015021-pol2qm74 7490 2 , , , cord-015021-pol2qm74 7490 3 functions function NNS cord-015021-pol2qm74 7490 4 of of IN cord-015021-pol2qm74 7490 5 neutrophlis neutrophlis NNP cord-015021-pol2qm74 7490 6 which which WDT cord-015021-pol2qm74 7490 7 were be VBD cord-015021-pol2qm74 7490 8 phagocytic phagocytic JJ cord-015021-pol2qm74 7490 9 activity activity NN cord-015021-pol2qm74 7490 10 and and CC cord-015021-pol2qm74 7490 11 H2 h2 NN cord-015021-pol2qm74 7490 12 02 02 CD cord-015021-pol2qm74 7490 13 p p NN cord-015021-pol2qm74 7490 14 roduction roduction NN cord-015021-pol2qm74 7490 15 were be VBD cord-015021-pol2qm74 7490 16 remarkably remarkably RB cord-015021-pol2qm74 7490 17 enhanced enhance VBN cord-015021-pol2qm74 7490 18 by by IN cord-015021-pol2qm74 7490 19 admlnlstratlon admlnlstratlon NN cord-015021-pol2qm74 7490 20 of of IN cord-015021-pol2qm74 7490 21 rhG rhG NNP cord-015021-pol2qm74 7490 22 - - HYPH cord-015021-pol2qm74 7490 23 CS~(50 CS~(50 NNP cord-015021-pol2qm74 7490 24 ~ ~ NFP cord-015021-pol2qm74 7490 25 9 9 CD cord-015021-pol2qm74 7490 26 / / SYM cord-015021-pol2qm74 7490 27 ks ks NNP cord-015021-pol2qm74 7490 28 b b NNP cord-015021-pol2qm74 7490 29 ody ody NNP cord-015021-pol2qm74 7490 30 wt wt NNP cord-015021-pol2qm74 7490 31 ) ) -RRB- cord-015021-pol2qm74 7490 32 ( ( -LRB- cord-015021-pol2qm74 7490 33 p<0.(15 p<0.(15 NNP cord-015021-pol2qm74 7490 34 ) ) -RRB- cord-015021-pol2qm74 7490 35 . . . cord-015021-pol2qm74 7491 1 These these DT cord-015021-pol2qm74 7491 2 findings finding NNS cord-015021-pol2qm74 7491 3 suggest suggest VBP cord-015021-pol2qm74 7491 4 that that IN cord-015021-pol2qm74 7491 5 combination combination NN cord-015021-pol2qm74 7491 6 therapy therapy NN cord-015021-pol2qm74 7491 7 of of IN cord-015021-pol2qm74 7491 8 rhCrCSF rhCrCSF NNP cord-015021-pol2qm74 7491 9 with with IN cord-015021-pol2qm74 7491 10 cephern cephern NNP cord-015021-pol2qm74 7491 11 antib antib NNP cord-015021-pol2qm74 7491 12 iotlcs(CMZ)is iotlcs(cmz)i VBZ cord-015021-pol2qm74 7491 13 an an DT cord-015021-pol2qm74 7491 14 efficient efficient JJ cord-015021-pol2qm74 7491 15 regime regime NN cord-015021-pol2qm74 7491 16 against against IN cord-015021-pol2qm74 7491 17 severe severe JJ cord-015021-pol2qm74 7491 18 infectlons.and infectlons.and NFP cord-015021-pol2qm74 7491 19 the the DT cord-015021-pol2qm74 7491 20 increased increase VBN cord-015021-pol2qm74 7491 21 ne ne NNP cord-015021-pol2qm74 7491 22 utrophils utrophils NNP cord-015021-pol2qm74 7491 23 counts count VBZ cord-015021-pol2qm74 7491 24 and and CC cord-015021-pol2qm74 7491 25 enhanced enhance VBN cord-015021-pol2qm74 7491 26 neutrophiis neutrophiis JJ cord-015021-pol2qm74 7491 27 functions function NNS cord-015021-pol2qm74 7491 28 were be VBD cord-015021-pol2qm74 7491 29 played play VBN cord-015021-pol2qm74 7491 30 a a DT cord-015021-pol2qm74 7491 31 important important JJ cord-015021-pol2qm74 7491 32 ro ro NNP cord-015021-pol2qm74 7491 33 le le NNP cord-015021-pol2qm74 7491 34 about about IN cord-015021-pol2qm74 7491 35 the the DT cord-015021-pol2qm74 7491 36 survival survival NN cord-015021-pol2qm74 7491 37 advantage advantage NN cord-015021-pol2qm74 7491 38 . . . cord-015021-pol2qm74 7492 1 Granulocyte Granulocyte NNP cord-015021-pol2qm74 7492 2 macrophage macrophage NN cord-015021-pol2qm74 7492 3 colony colony NN cord-015021-pol2qm74 7492 4 - - HYPH cord-015021-pol2qm74 7492 5 stimulating stimulate VBG cord-015021-pol2qm74 7492 6 factor factor NN cord-015021-pol2qm74 7492 7 ( ( -LRB- cord-015021-pol2qm74 7492 8 GM GM NNP cord-015021-pol2qm74 7492 9 - - HYPH cord-015021-pol2qm74 7492 10 CSF CSF NNP cord-015021-pol2qm74 7492 11 ) ) -RRB- cord-015021-pol2qm74 7492 12 is be VBZ cord-015021-pol2qm74 7492 13 a a DT cord-015021-pol2qm74 7492 14 haematopoietic haematopoietic JJ cord-015021-pol2qm74 7492 15 growth growth NN cord-015021-pol2qm74 7492 16 factor factor NN cord-015021-pol2qm74 7492 17 active active JJ cord-015021-pol2qm74 7492 18 on on IN cord-015021-pol2qm74 7492 19 neutrophils neutrophil NNS cord-015021-pol2qm74 7492 20 and and CC cord-015021-pol2qm74 7492 21 macrophages macrophage NNS cord-015021-pol2qm74 7492 22 . . . cord-015021-pol2qm74 7493 1 Leukopenia leukopenia NN cord-015021-pol2qm74 7493 2 often often RB cord-015021-pol2qm74 7493 3 occurs occur VBZ cord-015021-pol2qm74 7493 4 following follow VBG cord-015021-pol2qm74 7493 5 renal renal JJ cord-015021-pol2qm74 7493 6 transplantation transplantation NN cord-015021-pol2qm74 7493 7 and and CC cord-015021-pol2qm74 7493 8 can can MD cord-015021-pol2qm74 7493 9 be be VB cord-015021-pol2qm74 7493 10 associated associate VBN cord-015021-pol2qm74 7493 11 with with IN cord-015021-pol2qm74 7493 12 infection infection NN cord-015021-pol2qm74 7493 13 and/or and/or CC cord-015021-pol2qm74 7493 14 the the DT cord-015021-pol2qm74 7493 15 myelosuppressive myelosuppressive JJ cord-015021-pol2qm74 7493 16 effect effect NN cord-015021-pol2qm74 7493 17 of of IN cord-015021-pol2qm74 7493 18 azathioprine azathioprine NN cord-015021-pol2qm74 7493 19 . . . cord-015021-pol2qm74 7494 1 Aim aim VB cord-015021-pol2qm74 7494 2 : : : cord-015021-pol2qm74 7494 3 We -PRON- PRP cord-015021-pol2qm74 7494 4 report report VBP cord-015021-pol2qm74 7494 5 the the DT cord-015021-pol2qm74 7494 6 use use NN cord-015021-pol2qm74 7494 7 of of IN cord-015021-pol2qm74 7494 8 GM GM NNP cord-015021-pol2qm74 7494 9 - - HYPH cord-015021-pol2qm74 7494 10 CSF CSF NNP cord-015021-pol2qm74 7494 11 in in IN cord-015021-pol2qm74 7494 12 17 17 CD cord-015021-pol2qm74 7494 13 renal renal JJ cord-015021-pol2qm74 7494 14 allograft allograft NN cord-015021-pol2qm74 7494 15 recipients recipient NNS cord-015021-pol2qm74 7494 16 with with IN cord-015021-pol2qm74 7494 17 leukopenia leukopenia NN cord-015021-pol2qm74 7494 18 . . . cord-015021-pol2qm74 7495 1 Nonglycosylated Nonglycosylated NNP cord-015021-pol2qm74 7496 1 recombinant recombinant JJ cord-015021-pol2qm74 7496 2 GM GM NNP cord-015021-pol2qm74 7496 3 - - HYPH cord-015021-pol2qm74 7496 4 CSF CSF NNP cord-015021-pol2qm74 7496 5 was be VBD cord-015021-pol2qm74 7496 6 obtained obtain VBN cord-015021-pol2qm74 7496 7 from from IN cord-015021-pol2qm74 7496 8 E. E. NNP cord-015021-pol2qm74 7496 9 coli coli NNS cord-015021-pol2qm74 7496 10 transvected transvecte VBN cord-015021-pol2qm74 7496 11 by by IN cord-015021-pol2qm74 7496 12 human human JJ cord-015021-pol2qm74 7496 13 GM GM NNP cord-015021-pol2qm74 7496 14 - - HYPH cord-015021-pol2qm74 7496 15 CSF csf NN cord-015021-pol2qm74 7496 16 gene gene NN cord-015021-pol2qm74 7496 17 . . . cord-015021-pol2qm74 7497 1 M M NNP cord-015021-pol2qm74 7497 2 ~ ~ CD cord-015021-pol2qm74 7497 3 terial terial NNP cord-015021-pol2qm74 7497 4 ~,nd ~,nd NNP cord-015021-pol2qm74 7497 5 Methods Methods NNP cord-015021-pol2qm74 7497 6 : : : cord-015021-pol2qm74 7497 7 Written write VBN cord-015021-pol2qm74 7498 1 informed informed JJ cord-015021-pol2qm74 7498 2 consent consent NN cord-015021-pol2qm74 7498 3 was be VBD cord-015021-pol2qm74 7498 4 obtained obtain VBN cord-015021-pol2qm74 7498 5 from from IN cord-015021-pol2qm74 7498 6 all all DT cord-015021-pol2qm74 7498 7 patients patient NNS cord-015021-pol2qm74 7498 8 . . . cord-015021-pol2qm74 7499 1 Patients patient NNS cord-015021-pol2qm74 7499 2 were be VBD cord-015021-pol2qm74 7499 3 suffering suffer VBG cord-015021-pol2qm74 7499 4 from from IN cord-015021-pol2qm74 7499 5 toxic toxic JJ cord-015021-pol2qm74 7499 6 neutropenia neutropenia NN cord-015021-pol2qm74 7500 1 ( ( -LRB- cord-015021-pol2qm74 7500 2 neutrophils neutrophil NNS cord-015021-pol2qm74 7500 3 < < XX cord-015021-pol2qm74 7500 4 500 500 CD cord-015021-pol2qm74 7500 5 / / SYM cord-015021-pol2qm74 7500 6 mm mm NNP cord-015021-pol2qm74 7500 7 3 3 CD cord-015021-pol2qm74 7500 8 ) ) -RRB- cord-015021-pol2qm74 7500 9 with with IN cord-015021-pol2qm74 7500 10 medullar medullar JJ cord-015021-pol2qm74 7500 11 hypocellularity hypocellularity NN cord-015021-pol2qm74 7500 12 on on IN cord-015021-pol2qm74 7500 13 bone bone NN cord-015021-pol2qm74 7500 14 marrow marrow NN cord-015021-pol2qm74 7500 15 aspiration aspiration NN cord-015021-pol2qm74 7500 16 , , , cord-015021-pol2qm74 7500 17 or or CC cord-015021-pol2qm74 7500 18 leukopenia leukopenia NN cord-015021-pol2qm74 7500 19 ( ( -LRB- cord-015021-pol2qm74 7500 20 neutrophils neutrophil NNS cord-015021-pol2qm74 7500 21 < < XX cord-015021-pol2qm74 7500 22 1000 1000 CD cord-015021-pol2qm74 7501 1 /ram /ram CD cord-015021-pol2qm74 7501 2 3 3 LS cord-015021-pol2qm74 7501 3 ) ) -RRB- cord-015021-pol2qm74 7501 4 with with IN cord-015021-pol2qm74 7501 5 cytomegalovirus cytomegalovirus JJ cord-015021-pol2qm74 7501 6 infection infection NN cord-015021-pol2qm74 7501 7 requiring require VBG cord-015021-pol2qm74 7501 8 ganciclovir ganciclovir NNP cord-015021-pol2qm74 7501 9 administTation administtation NN cord-015021-pol2qm74 7501 10 . . . cord-015021-pol2qm74 7502 1 GM GM NNP cord-015021-pol2qm74 7502 2 - - HYPH cord-015021-pol2qm74 7502 3 CSF CSF NNP cord-015021-pol2qm74 7502 4 was be VBD cord-015021-pol2qm74 7502 5 given give VBN cord-015021-pol2qm74 7502 6 subcutaneously subcutaneously RB cord-015021-pol2qm74 7502 7 at at IN cord-015021-pol2qm74 7502 8 a a DT cord-015021-pol2qm74 7502 9 dally dally NN cord-015021-pol2qm74 7502 10 dose dose NN cord-015021-pol2qm74 7502 11 of of IN cord-015021-pol2qm74 7502 12 2 2 CD cord-015021-pol2qm74 7502 13 to to TO cord-015021-pol2qm74 7502 14 5 5 CD cord-015021-pol2qm74 7502 15 mcg mcg NN cord-015021-pol2qm74 7502 16 / / SYM cord-015021-pol2qm74 7502 17 kg kg NNP cord-015021-pol2qm74 7502 18 / / SYM cord-015021-pol2qm74 7502 19 day day NN cord-015021-pol2qm74 7502 20 , , , cord-015021-pol2qm74 7502 21 according accord VBG cord-015021-pol2qm74 7502 22 to to IN cord-015021-pol2qm74 7502 23 renal renal JJ cord-015021-pol2qm74 7502 24 function function NN cord-015021-pol2qm74 7502 25 . . . cord-015021-pol2qm74 7503 1 Results result NNS cord-015021-pol2qm74 7503 2 : : : cord-015021-pol2qm74 7504 1 In in IN cord-015021-pol2qm74 7504 2 all all DT cord-015021-pol2qm74 7504 3 cases case NNS cord-015021-pol2qm74 7504 4 , , , cord-015021-pol2qm74 7504 5 neutrophil neutrophil NN cord-015021-pol2qm74 7504 6 counts count NNS cord-015021-pol2qm74 7504 7 returned return VBD cord-015021-pol2qm74 7504 8 to to IN cord-015021-pol2qm74 7504 9 normal normal JJ cord-015021-pol2qm74 7504 10 levels level NNS cord-015021-pol2qm74 7504 11 within within IN cord-015021-pol2qm74 7504 12 1 1 CD cord-015021-pol2qm74 7504 13 to to IN cord-015021-pol2qm74 7504 14 4 4 CD cord-015021-pol2qm74 7504 15 days day NNS cord-015021-pol2qm74 7504 16 . . . cord-015021-pol2qm74 7505 1 In in IN cord-015021-pol2qm74 7505 2 most most JJS cord-015021-pol2qm74 7505 3 of of IN cord-015021-pol2qm74 7505 4 them -PRON- PRP cord-015021-pol2qm74 7505 5 , , , cord-015021-pol2qm74 7505 6 spectacular spectacular JJ cord-015021-pol2qm74 7505 7 correction correction NN cord-015021-pol2qm74 7505 8 was be VBD cord-015021-pol2qm74 7505 9 observed observe VBN cord-015021-pol2qm74 7505 10 within within IN cord-015021-pol2qm74 7505 11 24 24 CD cord-015021-pol2qm74 7505 12 hours hour NNS cord-015021-pol2qm74 7505 13 , , , cord-015021-pol2qm74 7505 14 with with IN cord-015021-pol2qm74 7505 15 a a DT cord-015021-pol2qm74 7505 16 single single JJ cord-015021-pol2qm74 7505 17 injection injection NN cord-015021-pol2qm74 7505 18 . . . cord-015021-pol2qm74 7506 1 Adverse adverse JJ cord-015021-pol2qm74 7506 2 events event NNS cord-015021-pol2qm74 7506 3 due due JJ cord-015021-pol2qm74 7506 4 to to IN cord-015021-pol2qm74 7506 5 GM GM NNP cord-015021-pol2qm74 7506 6 - - HYPH cord-015021-pol2qm74 7506 7 CSF CSF NNP cord-015021-pol2qm74 7506 8 at at IN cord-015021-pol2qm74 7506 9 this this DT cord-015021-pol2qm74 7506 10 dose dose NN cord-015021-pol2qm74 7506 11 were be VBD cord-015021-pol2qm74 7506 12 mild mild JJ cord-015021-pol2qm74 7506 13 and and CC cord-015021-pol2qm74 7506 14 easily easily RB cord-015021-pol2qm74 7506 15 managed manage VBN cord-015021-pol2qm74 7506 16 ( ( -LRB- cord-015021-pol2qm74 7506 17 2 2 CD cord-015021-pol2qm74 7506 18 cases case NNS cord-015021-pol2qm74 7506 19 of of IN cord-015021-pol2qm74 7506 20 bone bone NN cord-015021-pol2qm74 7506 21 pain pain NN cord-015021-pol2qm74 7506 22 treated treat VBN cord-015021-pol2qm74 7506 23 with with IN cord-015021-pol2qm74 7506 24 paracetamol paracetamol NNP cord-015021-pol2qm74 7506 25 ) ) -RRB- cord-015021-pol2qm74 7506 26 . . . cord-015021-pol2qm74 7507 1 One one CD cord-015021-pol2qm74 7507 2 acute acute JJ cord-015021-pol2qm74 7507 3 rejection rejection NN cord-015021-pol2qm74 7507 4 episode episode NN cord-015021-pol2qm74 7507 5 was be VBD cord-015021-pol2qm74 7507 6 observed observe VBN cord-015021-pol2qm74 7507 7 after after IN cord-015021-pol2qm74 7507 8 correction correction NN cord-015021-pol2qm74 7507 9 of of IN cord-015021-pol2qm74 7507 10 leukopenia leukopenia NN cord-015021-pol2qm74 7507 11 . . . cord-015021-pol2qm74 7508 1 Conclusion conclusion NN cord-015021-pol2qm74 7508 2 : : : cord-015021-pol2qm74 7509 1 On on IN cord-015021-pol2qm74 7509 2 the the DT cord-015021-pol2qm74 7509 3 basis basis NN cord-015021-pol2qm74 7509 4 of of IN cord-015021-pol2qm74 7509 5 this this DT cord-015021-pol2qm74 7509 6 study study NN cord-015021-pol2qm74 7509 7 , , , cord-015021-pol2qm74 7509 8 it -PRON- PRP cord-015021-pol2qm74 7509 9 appears appear VBZ cord-015021-pol2qm74 7509 10 that that IN cord-015021-pol2qm74 7509 11 GM GM NNP cord-015021-pol2qm74 7509 12 - - HYPH cord-015021-pol2qm74 7509 13 CSF CSF NNP cord-015021-pol2qm74 7509 14 at at IN cord-015021-pol2qm74 7509 15 a a DT cord-015021-pol2qm74 7509 16 dose dose NN cord-015021-pol2qm74 7509 17 below below IN cord-015021-pol2qm74 7509 18 5 5 CD cord-015021-pol2qm74 7509 19 mcg mcg NNP cord-015021-pol2qm74 7509 20 / / SYM cord-015021-pol2qm74 7509 21 kg kg NNP cord-015021-pol2qm74 7509 22 / / SYM cord-015021-pol2qm74 7509 23 day day NN cord-015021-pol2qm74 7509 24 is be VBZ cord-015021-pol2qm74 7509 25 an an DT cord-015021-pol2qm74 7509 26 effective effective JJ cord-015021-pol2qm74 7509 27 treatment treatment NN cord-015021-pol2qm74 7509 28 for for IN cord-015021-pol2qm74 7509 29 renal renal JJ cord-015021-pol2qm74 7509 30 transplant transplant NN cord-015021-pol2qm74 7509 31 recipients recipient NNS cord-015021-pol2qm74 7509 32 with with IN cord-015021-pol2qm74 7509 33 leukopenia leukopenia NN cord-015021-pol2qm74 7509 34 associated associate VBN cord-015021-pol2qm74 7509 35 with with IN cord-015021-pol2qm74 7509 36 CMV CMV NNP cord-015021-pol2qm74 7509 37 infection infection NN cord-015021-pol2qm74 7509 38 or or CC cord-015021-pol2qm74 7509 39 toxic toxic JJ cord-015021-pol2qm74 7509 40 neutropenia neutropenia NN cord-015021-pol2qm74 7509 41 . . . cord-015021-pol2qm74 7510 1 Department Department NNP cord-015021-pol2qm74 7510 2 of of IN cord-015021-pol2qm74 7510 3 Nephrology Nephrology NNP cord-015021-pol2qm74 7510 4 , , , cord-015021-pol2qm74 7510 5 161 161 CD cord-015021-pol2qm74 7510 6 , , , cord-015021-pol2qm74 7510 7 rue rue FW cord-015021-pol2qm74 7510 8 de de FW cord-015021-pol2qm74 7510 9 S S NNP cord-015021-pol2qm74 7510 10 ~ ~ CD cord-015021-pol2qm74 7510 11 vres vre NNS cord-015021-pol2qm74 7510 12 , , , cord-015021-pol2qm74 7510 13 HOPITAL HOPITAL NNP cord-015021-pol2qm74 7510 14 NECKER NECKER NNP cord-015021-pol2qm74 7510 15 , , , cord-015021-pol2qm74 7510 16 75743 75743 CD cord-015021-pol2qm74 7510 17 PARIS PARIS NNP cord-015021-pol2qm74 7510 18 , , , cord-015021-pol2qm74 7510 19 FRANCE FRANCE NNP cord-015021-pol2qm74 7510 20 . . . cord-015021-pol2qm74 7511 1 Changes change NNS cord-015021-pol2qm74 7511 2 in in IN cord-015021-pol2qm74 7511 3 serum serum NN cord-015021-pol2qm74 7511 4 G G NNP cord-015021-pol2qm74 7511 5 - - HYPH cord-015021-pol2qm74 7511 6 CSF CSF NNP cord-015021-pol2qm74 7511 7 and and CC cord-015021-pol2qm74 7511 8 IL-6 IL-6 NNP cord-015021-pol2qm74 7511 9 after after IN cord-015021-pol2qm74 7511 10 surgical surgical JJ cord-015021-pol2qm74 7511 11 intervention intervention NN cord-015021-pol2qm74 7511 12 Hitoshi Hitoshi NNP cord-015021-pol2qm74 7511 13 Toda Toda NNP cord-015021-pol2qm74 7511 14 1 1 CD cord-015021-pol2qm74 7511 15 , , , cord-015021-pol2qm74 7511 16 Atsuo Atsuo NNP cord-015021-pol2qm74 7511 17 Murata Murata NNP cord-015021-pol2qm74 7511 18 1 1 CD cord-015021-pol2qm74 7511 19 , , , cord-015021-pol2qm74 7511 20 Hidewaki Hidewaki NNP cord-015021-pol2qm74 7511 21 Nakagawa Nakagawa NNP cord-015021-pol2qm74 7511 22 1 1 CD cord-015021-pol2qm74 7511 23 , , , cord-015021-pol2qm74 7511 24 Takesada Takesada NNP cord-015021-pol2qm74 7511 25 Mori Mori NNP cord-015021-pol2qm74 7511 26 1 1 CD cord-015021-pol2qm74 7511 27 , , , cord-015021-pol2qm74 7511 28 Nariaki Nariaki NNP cord-015021-pol2qm74 7511 29 Matsuura Matsuura NNP cord-015021-pol2qm74 7511 30 2 2 CD cord-015021-pol2qm74 7511 31 1Osaka 1Osaka NNP cord-015021-pol2qm74 7511 32 University University NNP cord-015021-pol2qm74 7511 33 Medical Medical NNP cord-015021-pol2qm74 7511 34 School School NNP cord-015021-pol2qm74 7511 35 , , , cord-015021-pol2qm74 7511 36 Osaka Osaka NNP cord-015021-pol2qm74 7511 37 , , , cord-015021-pol2qm74 7511 38 2Wakayama 2Wakayama NNP cord-015021-pol2qm74 7511 39 Medical Medical NNP cord-015021-pol2qm74 7511 40 School School NNP cord-015021-pol2qm74 7511 41 , , , cord-015021-pol2qm74 7511 42 Wakayama Wakayama NNP cord-015021-pol2qm74 7511 43 , , , cord-015021-pol2qm74 7511 44 Japan Japan NNP cord-015021-pol2qm74 7512 1 We -PRON- PRP cord-015021-pol2qm74 7512 2 measured measure VBD cord-015021-pol2qm74 7512 3 serum serum NN cord-015021-pol2qm74 7512 4 immunoreactive immunoreactive NNP cord-015021-pol2qm74 7512 5 interleukin interleukin NNP cord-015021-pol2qm74 7512 6 6 6 CD cord-015021-pol2qm74 7512 7 ( ( -LRB- cord-015021-pol2qm74 7512 8 IL-6 IL-6 NNP cord-015021-pol2qm74 7512 9 ) ) -RRB- cord-015021-pol2qm74 7512 10 and and CC cord-015021-pol2qm74 7512 11 granulocyte granulocyte NN cord-015021-pol2qm74 7512 12 colony colony NN cord-015021-pol2qm74 7512 13 - - HYPH cord-015021-pol2qm74 7512 14 stimulating stimulate VBG cord-015021-pol2qm74 7512 15 factor factor NN cord-015021-pol2qm74 7513 1 ( ( -LRB- cord-015021-pol2qm74 7513 2 G G NNP cord-015021-pol2qm74 7513 3 - - HYPH cord-015021-pol2qm74 7513 4 CSF CSF NNP cord-015021-pol2qm74 7513 5 ) ) -RRB- cord-015021-pol2qm74 7513 6 levels level NNS cord-015021-pol2qm74 7513 7 of of IN cord-015021-pol2qm74 7513 8 the the DT cord-015021-pol2qm74 7513 9 patients patient NNS cord-015021-pol2qm74 7513 10 undergoing undergo VBG cord-015021-pol2qm74 7513 11 major major JJ cord-015021-pol2qm74 7513 12 thoraco thoraco NNS cord-015021-pol2qm74 7513 13 - - HYPH cord-015021-pol2qm74 7513 14 abdominal abdominal JJ cord-015021-pol2qm74 7513 15 surgery surgery NN cord-015021-pol2qm74 7513 16 for for IN cord-015021-pol2qm74 7513 17 esophageal esophageal JJ cord-015021-pol2qm74 7513 18 cancer cancer NN cord-015021-pol2qm74 7513 19 . . . cord-015021-pol2qm74 7514 1 Serum serum NN cord-015021-pol2qm74 7514 2 samples sample NNS cord-015021-pol2qm74 7514 3 were be VBD cord-015021-pol2qm74 7514 4 collected collect VBN cord-015021-pol2qm74 7514 5 from from IN cord-015021-pol2qm74 7514 6 eight eight CD cord-015021-pol2qm74 7514 7 patients patient NNS cord-015021-pol2qm74 7514 8 on on IN cord-015021-pol2qm74 7514 9 the the DT cord-015021-pol2qm74 7514 10 day day NN cord-015021-pol2qm74 7514 11 before before IN cord-015021-pol2qm74 7514 12 surgery surgery NN cord-015021-pol2qm74 7514 13 , , , cord-015021-pol2qm74 7514 14 at at IN cord-015021-pol2qm74 7514 15 the the DT cord-015021-pol2qm74 7514 16 time time NN cord-015021-pol2qm74 7514 17 of of IN cord-015021-pol2qm74 7514 18 operation operation NN cord-015021-pol2qm74 7514 19 , , , cord-015021-pol2qm74 7514 20 and and CC cord-015021-pol2qm74 7514 21 thereafter thereafter RB cord-015021-pol2qm74 7514 22 at at IN cord-015021-pol2qm74 7514 23 suitable suitable JJ cord-015021-pol2qm74 7514 24 intervals interval NNS cord-015021-pol2qm74 7514 25 for for IN cord-015021-pol2qm74 7514 26 one one CD cord-015021-pol2qm74 7514 27 week week NN cord-015021-pol2qm74 7514 28 . . . cord-015021-pol2qm74 7515 1 IL-6 IL-6 NNP cord-015021-pol2qm74 7515 2 and and CC cord-015021-pol2qm74 7515 3 G G NNP cord-015021-pol2qm74 7515 4 - - HYPH cord-015021-pol2qm74 7515 5 CSF CSF NNP cord-015021-pol2qm74 7515 6 were be VBD cord-015021-pol2qm74 7515 7 measured measure VBN cord-015021-pol2qm74 7515 8 by by IN cord-015021-pol2qm74 7515 9 means mean NNS cord-015021-pol2qm74 7515 10 of of IN cord-015021-pol2qm74 7515 11 enzyme enzyme NN cord-015021-pol2qm74 7515 12 linked link VBN cord-015021-pol2qm74 7515 13 immunoassay immunoassay NN cord-015021-pol2qm74 7515 14 . . . cord-015021-pol2qm74 7516 1 The the DT cord-015021-pol2qm74 7516 2 normal normal JJ cord-015021-pol2qm74 7516 3 range range NN cord-015021-pol2qm74 7516 4 of of IN cord-015021-pol2qm74 7516 5 serum serum NN cord-015021-pol2qm74 7516 6 ] ] -RRB- cord-015021-pol2qm74 7516 7 L-6 L-6 NNP cord-015021-pol2qm74 7516 8 was be VBD cord-015021-pol2qm74 7516 9 less less JJR cord-015021-pol2qm74 7516 10 than than IN cord-015021-pol2qm74 7516 11 2 2 CD cord-015021-pol2qm74 7516 12 pg pg NN cord-015021-pol2qm74 7516 13 / / SYM cord-015021-pol2qm74 7516 14 ml ml NN cord-015021-pol2qm74 7516 15 and and CC cord-015021-pol2qm74 7516 16 G G NNP cord-015021-pol2qm74 7516 17 - - HYPH cord-015021-pol2qm74 7516 18 CSF CSF NNP cord-015021-pol2qm74 7517 1 less less JJR cord-015021-pol2qm74 7517 2 than than IN cord-015021-pol2qm74 7517 3 4 4 CD cord-015021-pol2qm74 7517 4 pg pg NN cord-015021-pol2qm74 7517 5 / / SYM cord-015021-pol2qm74 7517 6 ml ml NN cord-015021-pol2qm74 7517 7 . . . cord-015021-pol2qm74 7518 1 Values value NNS cord-015021-pol2qm74 7518 2 between between IN cord-015021-pol2qm74 7518 3 groups group NNS cord-015021-pol2qm74 7518 4 were be VBD cord-015021-pol2qm74 7518 5 compared compare VBN cord-015021-pol2qm74 7518 6 with with IN cord-015021-pol2qm74 7518 7 linear linear JJ cord-015021-pol2qm74 7518 8 regression regression NN cord-015021-pol2qm74 7518 9 analysis analysis NN cord-015021-pol2qm74 7518 10 . . . cord-015021-pol2qm74 7519 1 Both both DT cord-015021-pol2qm74 7519 2 serum serum NN cord-015021-pol2qm74 7519 3 G G NNP cord-015021-pol2qm74 7519 4 - - HYPH cord-015021-pol2qm74 7519 5 CSF CSF NNP cord-015021-pol2qm74 7519 6 and and CC cord-015021-pol2qm74 7519 7 IL-6 IL-6 NNP cord-015021-pol2qm74 7519 8 levels level NNS cord-015021-pol2qm74 7519 9 reached reach VBD cord-015021-pol2qm74 7519 10 their -PRON- PRP$ cord-015021-pol2qm74 7519 11 maximal maximal JJ cord-015021-pol2qm74 7519 12 levels level NNS cord-015021-pol2qm74 7519 13 at at IN cord-015021-pol2qm74 7519 14 the the DT cord-015021-pol2qm74 7519 15 first first JJ cord-015021-pol2qm74 7519 16 postoperative postoperative JJ cord-015021-pol2qm74 7519 17 day day NN cord-015021-pol2qm74 7519 18 and and CC cord-015021-pol2qm74 7519 19 decreased decrease VBD cord-015021-pol2qm74 7519 20 thereafter thereafter RB cord-015021-pol2qm74 7519 21 . . . cord-015021-pol2qm74 7520 1 The the DT cord-015021-pol2qm74 7520 2 correlation correlation NN cord-015021-pol2qm74 7520 3 between between IN cord-015021-pol2qm74 7520 4 G G NNP cord-015021-pol2qm74 7520 5 - - HYPH cord-015021-pol2qm74 7520 6 CSF CSF NNP cord-015021-pol2qm74 7520 7 ( ( -LRB- cord-015021-pol2qm74 7520 8 y y NNP cord-015021-pol2qm74 7520 9 ) ) -RRB- cord-015021-pol2qm74 7520 10 and and CC cord-015021-pol2qm74 7520 11 IL-6 IL-6 NNP cord-015021-pol2qm74 7520 12 ( ( -LRB- cord-015021-pol2qm74 7520 13 x x NN cord-015021-pol2qm74 7520 14 ) ) -RRB- cord-015021-pol2qm74 7520 15 was be VBD cord-015021-pol2qm74 7520 16 y=3.28x+6.16 y=3.28x+6.16 VBN cord-015021-pol2qm74 7520 17 ( ( -LRB- cord-015021-pol2qm74 7520 18 r=0.786 r=0.786 NNP cord-015021-pol2qm74 7520 19 , , , cord-015021-pol2qm74 7520 20 n=86 n=86 NNP cord-015021-pol2qm74 7520 21 , , , cord-015021-pol2qm74 7520 22 p<0.01 p<0.01 NNP cord-015021-pol2qm74 7520 23 ) ) -RRB- cord-015021-pol2qm74 7520 24 , , , cord-015021-pol2qm74 7520 25 showing show VBG cord-015021-pol2qm74 7520 26 a a DT cord-015021-pol2qm74 7520 27 significant significant JJ cord-015021-pol2qm74 7520 28 correlation correlation NN cord-015021-pol2qm74 7520 29 . . . cord-015021-pol2qm74 7521 1 In in IN cord-015021-pol2qm74 7521 2 the the DT cord-015021-pol2qm74 7521 3 case case NN cord-015021-pol2qm74 7521 4 who who WP cord-015021-pol2qm74 7521 5 suffered suffer VBD cord-015021-pol2qm74 7521 6 from from IN cord-015021-pol2qm74 7521 7 aspiration aspiration NN cord-015021-pol2qm74 7521 8 pneumonia pneumonia NN cord-015021-pol2qm74 7521 9 and and CC cord-015021-pol2qm74 7521 10 ARDS ARDS NNP cord-015021-pol2qm74 7521 11 at at IN cord-015021-pol2qm74 7521 12 the the DT cord-015021-pol2qm74 7521 13 second second JJ cord-015021-pol2qm74 7521 14 postoperative postoperative JJ cord-015021-pol2qm74 7521 15 day day NN cord-015021-pol2qm74 7521 16 , , , cord-015021-pol2qm74 7521 17 the the DT cord-015021-pol2qm74 7521 18 peak peak NN cord-015021-pol2qm74 7521 19 level level NN cord-015021-pol2qm74 7521 20 of of IN cord-015021-pol2qm74 7521 21 IL-6 IL-6 NNP cord-015021-pol2qm74 7521 22 was be VBD cord-015021-pol2qm74 7521 23 50 50 CD cord-015021-pol2qm74 7521 24 pg pg NN cord-015021-pol2qm74 7521 25 / / SYM cord-015021-pol2qm74 7521 26 ml ml NN cord-015021-pol2qm74 7521 27 and and CC cord-015021-pol2qm74 7521 28 G G NNP cord-015021-pol2qm74 7521 29 - - HYPH cord-015021-pol2qm74 7521 30 CSF CSF NNP cord-015021-pol2qm74 7521 31 69 69 CD cord-015021-pol2qm74 7521 32 pg pg NN cord-015021-pol2qm74 7521 33 / / SYM cord-015021-pol2qm74 7521 34 ml ml NN cord-015021-pol2qm74 7521 35 respectively respectively RB cord-015021-pol2qm74 7521 36 . . . cord-015021-pol2qm74 7522 1 The the DT cord-015021-pol2qm74 7522 2 estimated estimate VBN cord-015021-pol2qm74 7522 3 value value NN cord-015021-pol2qm74 7522 4 of of IN cord-015021-pol2qm74 7522 5 G G NNP cord-015021-pol2qm74 7522 6 - - HYPH cord-015021-pol2qm74 7522 7 CSF CSF NNP cord-015021-pol2qm74 7522 8 was be VBD cord-015021-pol2qm74 7523 1 171 171 CD cord-015021-pol2qm74 7523 2 pg pg NNP cord-015021-pol2qm74 7523 3 / / SYM cord-015021-pol2qm74 7523 4 mi mi NNP cord-015021-pol2qm74 7523 5 by by IN cord-015021-pol2qm74 7523 6 the the DT cord-015021-pol2qm74 7523 7 regression regression NN cord-015021-pol2qm74 7523 8 equation equation NN cord-015021-pol2qm74 7523 9 . . . cord-015021-pol2qm74 7524 1 This this DT cord-015021-pol2qm74 7524 2 means mean VBZ cord-015021-pol2qm74 7524 3 the the DT cord-015021-pol2qm74 7524 4 real real JJ cord-015021-pol2qm74 7524 5 G G NNP cord-015021-pol2qm74 7524 6 - - HYPH cord-015021-pol2qm74 7524 7 CSE CSE NNP cord-015021-pol2qm74 7524 8 level level NN cord-015021-pol2qm74 7524 9 was be VBD cord-015021-pol2qm74 7524 10 less less JJR cord-015021-pol2qm74 7524 11 than than IN cord-015021-pol2qm74 7524 12 half half NN cord-015021-pol2qm74 7524 13 of of IN cord-015021-pol2qm74 7524 14 the the DT cord-015021-pol2qm74 7524 15 estimated estimate VBN cord-015021-pol2qm74 7524 16 value value NN cord-015021-pol2qm74 7524 17 . . . cord-015021-pol2qm74 7525 1 It -PRON- PRP cord-015021-pol2qm74 7525 2 suggests suggest VBZ cord-015021-pol2qm74 7525 3 that that IN cord-015021-pol2qm74 7525 4 low low JJ cord-015021-pol2qm74 7525 5 responsiveness responsiveness NN cord-015021-pol2qm74 7525 6 of of IN cord-015021-pol2qm74 7525 7 G G NNP cord-015021-pol2qm74 7525 8 - - HYPH cord-015021-pol2qm74 7525 9 CSF CSF NNP cord-015021-pol2qm74 7525 10 is be VBZ cord-015021-pol2qm74 7525 11 one one CD cord-015021-pol2qm74 7525 12 of of IN cord-015021-pol2qm74 7525 13 the the DT cord-015021-pol2qm74 7525 14 reason reason NN cord-015021-pol2qm74 7525 15 of of IN cord-015021-pol2qm74 7525 16 immunodeficient immunodeficient JJ cord-015021-pol2qm74 7525 17 state state NN cord-015021-pol2qm74 7525 18 after after IN cord-015021-pol2qm74 7525 19 the the DT cord-015021-pol2qm74 7525 20 major major JJ cord-015021-pol2qm74 7525 21 surgery surgery NN cord-015021-pol2qm74 7525 22 , , , cord-015021-pol2qm74 7525 23 Neutrophils Neutrophils NNP cord-015021-pol2qm74 7525 24 from from IN cord-015021-pol2qm74 7525 25 injured injure VBN cord-015021-pol2qm74 7525 26 patients patient NNS cord-015021-pol2qm74 7525 27 ingest ingest VBP cord-015021-pol2qm74 7525 28 and and CC cord-015021-pol2qm74 7525 29 kill kill VB cord-015021-pol2qm74 7525 30 bacteria bacteria NNS cord-015021-pol2qm74 7525 31 less less RBR cord-015021-pol2qm74 7525 32 efficiently efficiently RB cord-015021-pol2qm74 7525 33 as as IN cord-015021-pol2qm74 7525 34 compared compare VBN cord-015021-pol2qm74 7525 35 to to IN cord-015021-pol2qm74 7525 36 those those DT cord-015021-pol2qm74 7525 37 of of IN cord-015021-pol2qm74 7525 38 healthy healthy JJ cord-015021-pol2qm74 7525 39 individuals individual NNS cord-015021-pol2qm74 7525 40 , , , cord-015021-pol2qm74 7525 41 probably probably RB cord-015021-pol2qm74 7525 42 reflecting reflect VBG cord-015021-pol2qm74 7525 43 the the DT cord-015021-pol2qm74 7525 44 suppression suppression NN cord-015021-pol2qm74 7525 45 in in IN cord-015021-pol2qm74 7525 46 respiratoly respiratoly NNP cord-015021-pol2qm74 7525 47 burst burst NN cord-015021-pol2qm74 7525 48 which which WDT cord-015021-pol2qm74 7525 49 occurs occur VBZ cord-015021-pol2qm74 7525 50 after after IN cord-015021-pol2qm74 7525 51 severe severe JJ cord-015021-pol2qm74 7525 52 trauma trauma NN cord-015021-pol2qm74 7525 53 . . . cord-015021-pol2qm74 7526 1 One one CD cord-015021-pol2qm74 7526 2 of of IN cord-015021-pol2qm74 7526 3 the the DT cord-015021-pol2qm74 7526 4 main main JJ cord-015021-pol2qm74 7526 5 mechanisms mechanism NNS cord-015021-pol2qm74 7526 6 of of IN cord-015021-pol2qm74 7526 7 killing kill VBG cord-015021-pol2qm74 7526 8 bacteria bacteria NNS cord-015021-pol2qm74 7526 9 by by IN cord-015021-pol2qm74 7526 10 neutrophil neutrophil NN cord-015021-pol2qm74 7526 11 granulocytes granulocyte NNS cord-015021-pol2qm74 7526 12 is be VBZ cord-015021-pol2qm74 7526 13 production production NN cord-015021-pol2qm74 7526 14 of of IN cord-015021-pol2qm74 7526 15 oxygen oxygen NN cord-015021-pol2qm74 7526 16 radicals radical NNS cord-015021-pol2qm74 7526 17 ( ( -LRB- cord-015021-pol2qm74 7526 18 respiratory respiratory JJ cord-015021-pol2qm74 7526 19 burst burst NN cord-015021-pol2qm74 7526 20 ) ) -RRB- cord-015021-pol2qm74 7526 21 . . . cord-015021-pol2qm74 7527 1 Granulocyte Granulocyte NNP cord-015021-pol2qm74 7527 2 colony colony NN cord-015021-pol2qm74 7527 3 - - HYPH cord-015021-pol2qm74 7527 4 stimulating stimulate VBG cord-015021-pol2qm74 7527 5 factor factor NN cord-015021-pol2qm74 7527 6 ( ( -LRB- cord-015021-pol2qm74 7527 7 G G NNP cord-015021-pol2qm74 7527 8 - - HYPH cord-015021-pol2qm74 7527 9 CSF CSF NNP cord-015021-pol2qm74 7527 10 ) ) -RRB- cord-015021-pol2qm74 7527 11 , , , cord-015021-pol2qm74 7527 12 a a DT cord-015021-pol2qm74 7527 13 20kilodalton 20kilodalton CD cord-015021-pol2qm74 7527 14 cytokine cytokine NN cord-015021-pol2qm74 7527 15 , , , cord-015021-pol2qm74 7527 16 leads lead VBZ cord-015021-pol2qm74 7527 17 to to IN cord-015021-pol2qm74 7527 18 a a DT cord-015021-pol2qm74 7527 19 sustained sustained JJ cord-015021-pol2qm74 7527 20 , , , cord-015021-pol2qm74 7527 21 dose dose NN cord-015021-pol2qm74 7527 22 - - HYPH cord-015021-pol2qm74 7527 23 dependent dependent JJ cord-015021-pol2qm74 7527 24 increase increase NN cord-015021-pol2qm74 7527 25 in in IN cord-015021-pol2qm74 7527 26 circulating circulate VBG cord-015021-pol2qm74 7527 27 neutrophils neutrophil NNS cord-015021-pol2qm74 7527 28 . . . cord-015021-pol2qm74 7528 1 Thus thus RB cord-015021-pol2qm74 7528 2 , , , cord-015021-pol2qm74 7528 3 it -PRON- PRP cord-015021-pol2qm74 7528 4 was be VBD cord-015021-pol2qm74 7528 5 investigated investigate VBN cord-015021-pol2qm74 7528 6 whether whether IN cord-015021-pol2qm74 7528 7 filgrastim filgrastim NN cord-015021-pol2qm74 7528 8 ( ( -LRB- cord-015021-pol2qm74 7528 9 recombinant recombinant JJ cord-015021-pol2qm74 7528 10 human human JJ cord-015021-pol2qm74 7528 11 granulocyte granulocyte NN cord-015021-pol2qm74 7528 12 colony colony NN cord-015021-pol2qm74 7528 13 - - HYPH cord-015021-pol2qm74 7528 14 stimulating stimulate VBG cord-015021-pol2qm74 7528 15 factor factor NN cord-015021-pol2qm74 7528 16 , , , cord-015021-pol2qm74 7528 17 rhG rhG NNP cord-015021-pol2qm74 7528 18 - - HYPH cord-015021-pol2qm74 7528 19 CSF csf NN cord-015021-pol2qm74 7528 20 ) ) -RRB- cord-015021-pol2qm74 7528 21 therapy therapy NN cord-015021-pol2qm74 7528 22 fits fit VBZ cord-015021-pol2qm74 7528 23 for for IN cord-015021-pol2qm74 7528 24 prophylaxis prophylaxis NN cord-015021-pol2qm74 7528 25 of of IN cord-015021-pol2qm74 7528 26 sepsis sepsis NN cord-015021-pol2qm74 7528 27 in in IN cord-015021-pol2qm74 7528 28 postoperative postoperative JJ cord-015021-pol2qm74 7528 29 / / SYM cord-015021-pol2qm74 7528 30 posttraumatic posttraumatic JJ cord-015021-pol2qm74 7528 31 patients patient NNS cord-015021-pol2qm74 7528 32 , , , cord-015021-pol2qm74 7528 33 and and CC cord-015021-pol2qm74 7528 34 whether whether IN cord-015021-pol2qm74 7528 35 , , , cord-015021-pol2qm74 7528 36 besides besides IN cord-015021-pol2qm74 7528 37 an an DT cord-015021-pol2qm74 7528 38 expected expect VBN cord-015021-pol2qm74 7528 39 increase increase NN cord-015021-pol2qm74 7528 40 in in IN cord-015021-pol2qm74 7528 41 neutrophil neutrophil NN cord-015021-pol2qm74 7528 42 count count NN cord-015021-pol2qm74 7528 43 , , , cord-015021-pol2qm74 7528 44 filgrastim filgrastim NNP cord-015021-pol2qm74 7528 45 would would MD cord-015021-pol2qm74 7528 46 also also RB cord-015021-pol2qm74 7528 47 augment augment VB cord-015021-pol2qm74 7528 48 neutrophil neutrophil NN cord-015021-pol2qm74 7528 49 function function NN cord-015021-pol2qm74 7528 50 . . . cord-015021-pol2qm74 7529 1 MATERIAL material NN cord-015021-pol2qm74 7529 2 AND and CC cord-015021-pol2qm74 7529 3 METHODS method NNS cord-015021-pol2qm74 7529 4 : : : cord-015021-pol2qm74 7530 1 This this DT cord-015021-pol2qm74 7530 2 study study NN cord-015021-pol2qm74 7530 3 was be VBD cord-015021-pol2qm74 7530 4 designed design VBN cord-015021-pol2qm74 7530 5 as as IN cord-015021-pol2qm74 7530 6 an an DT cord-015021-pol2qm74 7530 7 open open JJ cord-015021-pol2qm74 7530 8 label label NN cord-015021-pol2qm74 7530 9 , , , cord-015021-pol2qm74 7530 10 prospective prospective JJ cord-015021-pol2qm74 7530 11 phase phase NN cord-015021-pol2qm74 7530 12 II ii CD cord-015021-pol2qm74 7530 13 study study NN cord-015021-pol2qm74 7530 14 of of IN cord-015021-pol2qm74 7530 15 filgrastim filgrastim NNP cord-015021-pol2qm74 7530 16 and and CC cord-015021-pol2qm74 7530 17 performed perform VBN cord-015021-pol2qm74 7530 18 in in IN cord-015021-pol2qm74 7530 19 a a DT cord-015021-pol2qm74 7530 20 surgical surgical JJ cord-015021-pol2qm74 7530 21 intensive intensive JJ cord-015021-pol2qm74 7530 22 care care NN cord-015021-pol2qm74 7530 23 unit unit NN cord-015021-pol2qm74 7530 24 ( ( -LRB- cord-015021-pol2qm74 7530 25 SICU SICU NNP cord-015021-pol2qm74 7530 26 ) ) -RRB- cord-015021-pol2qm74 7530 27 ( ( -LRB- cord-015021-pol2qm74 7530 28 university university NN cord-015021-pol2qm74 7530 29 hospital hospital NN cord-015021-pol2qm74 7530 30 ) ) -RRB- cord-015021-pol2qm74 7530 31 . . . cord-015021-pol2qm74 7531 1 10 10 CD cord-015021-pol2qm74 7531 2 postoperative postoperative JJ cord-015021-pol2qm74 7531 3 / / SYM cord-015021-pol2qm74 7531 4 post post JJ cord-015021-pol2qm74 7531 5 - - JJ cord-015021-pol2qm74 7531 6 traumatic traumatic JJ cord-015021-pol2qm74 7531 7 patients patient NNS cord-015021-pol2qm74 7531 8 with with IN cord-015021-pol2qm74 7531 9 a a DT cord-015021-pol2qm74 7531 10 Therapeutic Therapeutic NNP cord-015021-pol2qm74 7531 11 Intervention Intervention NNP cord-015021-pol2qm74 7531 12 Scoring Scoring NNP cord-015021-pol2qm74 7531 13 System System NNP cord-015021-pol2qm74 7531 14 ( ( -LRB- cord-015021-pol2qm74 7531 15 TISS TISS NNP cord-015021-pol2qm74 7531 16 ) ) -RRB- cord-015021-pol2qm74 7531 17 score score VBP cord-015021-pol2qm74 7531 18 greater great JJR cord-015021-pol2qm74 7531 19 than than IN cord-015021-pol2qm74 7531 20 30 30 CD cord-015021-pol2qm74 7531 21 were be VBD cord-015021-pol2qm74 7531 22 treated treat VBN cord-015021-pol2qm74 7531 23 with with IN cord-015021-pol2qm74 7531 24 filgrastim filgrastim NN cord-015021-pol2qm74 7531 25 ( ( -LRB- cord-015021-pol2qm74 7531 26 0.5 0.5 CD cord-015021-pol2qm74 7531 27 -1 -1 CD cord-015021-pol2qm74 7531 28 l.tg/kg/day l.tg/kg/day NNP cord-015021-pol2qm74 7531 29 ) ) -RRB- cord-015021-pol2qm74 7531 30 for for IN cord-015021-pol2qm74 7531 31 prophylaxis prophylaxis NN cord-015021-pol2qm74 7531 32 of of IN cord-015021-pol2qm74 7531 33 sepsis sepsis NN cord-015021-pol2qm74 7531 34 on on IN cord-015021-pol2qm74 7531 35 7 7 CD cord-015021-pol2qm74 7531 36 days day NNS cord-015021-pol2qm74 7531 37 or or CC cord-015021-pol2qm74 7531 38 until until IN cord-015021-pol2qm74 7531 39 discharge discharge NN cord-015021-pol2qm74 7531 40 from from IN cord-015021-pol2qm74 7531 41 the the DT cord-015021-pol2qm74 7531 42 SICU SICU NNP cord-015021-pol2qm74 7531 43 . . . cord-015021-pol2qm74 7532 1 Production production NN cord-015021-pol2qm74 7532 2 of of IN cord-015021-pol2qm74 7532 3 oxygen oxygen NN cord-015021-pol2qm74 7532 4 radicals radical NNS cord-015021-pol2qm74 7532 5 can can MD cord-015021-pol2qm74 7532 6 be be VB cord-015021-pol2qm74 7532 7 quantified quantify VBN cord-015021-pol2qm74 7532 8 by by IN cord-015021-pol2qm74 7532 9 analysis analysis NN cord-015021-pol2qm74 7532 10 of of IN cord-015021-pol2qm74 7532 11 FMLP FMLP NNP cord-015021-pol2qm74 7532 12 - - HYPH cord-015021-pol2qm74 7532 13 and and CC cord-015021-pol2qm74 7532 14 zymosan zymosan NNP cord-015021-pol2qm74 7532 15 - - HYPH cord-015021-pol2qm74 7532 16 induced induce VBN cord-015021-pol2qm74 7532 17 chemiluminescence chemiluminescence NN cord-015021-pol2qm74 7532 18 . . . cord-015021-pol2qm74 7533 1 Neutrophil Neutrophil NNP cord-015021-pol2qm74 7533 2 oxygen oxygen NN cord-015021-pol2qm74 7533 3 radical radical JJ cord-015021-pol2qm74 7533 4 production production NN cord-015021-pol2qm74 7533 5 was be VBD cord-015021-pol2qm74 7533 6 tested test VBN cord-015021-pol2qm74 7533 7 by by IN cord-015021-pol2qm74 7533 8 FMLP FMLP NNP cord-015021-pol2qm74 7533 9 - - HYPH cord-015021-pol2qm74 7533 10 and and CC cord-015021-pol2qm74 7533 11 zymosan zymosan NNP cord-015021-pol2qm74 7533 12 - - HYPH cord-015021-pol2qm74 7533 13 induced induce VBN cord-015021-pol2qm74 7533 14 chemiluminescence chemiluminescence NN cord-015021-pol2qm74 7533 15 by by IN cord-015021-pol2qm74 7533 16 the the DT cord-015021-pol2qm74 7533 17 polymorphonuclear polymorphonuclear JJ cord-015021-pol2qm74 7533 18 cells cell NNS cord-015021-pol2qm74 7533 19 ( ( -LRB- cord-015021-pol2qm74 7533 20 PMN PMN NNP cord-015021-pol2qm74 7533 21 ) ) -RRB- cord-015021-pol2qm74 7533 22 of of IN cord-015021-pol2qm74 7533 23 these these DT cord-015021-pol2qm74 7533 24 patients patient NNS cord-015021-pol2qm74 7533 25 in in IN cord-015021-pol2qm74 7533 26 multiple multiple JJ cord-015021-pol2qm74 7533 27 blood blood NN cord-015021-pol2qm74 7533 28 samples sample NNS cord-015021-pol2qm74 7533 29 over over IN cord-015021-pol2qm74 7533 30 a a DT cord-015021-pol2qm74 7533 31 period period NN cord-015021-pol2qm74 7533 32 of of IN cord-015021-pol2qm74 7533 33 up up IN cord-015021-pol2qm74 7533 34 to to TO cord-015021-pol2qm74 7533 35 14 14 CD cord-015021-pol2qm74 7533 36 days day NNS cord-015021-pol2qm74 7533 37 . . . cord-015021-pol2qm74 7534 1 RESULTS result NNS cord-015021-pol2qm74 7534 2 : : : cord-015021-pol2qm74 7535 1 None none NN cord-015021-pol2qm74 7535 2 of of IN cord-015021-pol2qm74 7535 3 the the DT cord-015021-pol2qm74 7535 4 patients patient NNS cord-015021-pol2qm74 7535 5 treated treat VBN cord-015021-pol2qm74 7535 6 with with IN cord-015021-pol2qm74 7535 7 filgrastim filgrastim NN cord-015021-pol2qm74 7535 8 for for IN cord-015021-pol2qm74 7535 9 prophylaxis prophylaxis NN cord-015021-pol2qm74 7535 10 of of IN cord-015021-pol2qm74 7535 11 sepsis sepsis NN cord-015021-pol2qm74 7535 12 developed develop VBD cord-015021-pol2qm74 7535 13 sepsis sepsis NN cord-015021-pol2qm74 7535 14 . . . cord-015021-pol2qm74 7536 1 In in IN cord-015021-pol2qm74 7536 2 vitro vitro FW cord-015021-pol2qm74 7536 3 FMLP FMLP NNP cord-015021-pol2qm74 7536 4 - - HYPH cord-015021-pol2qm74 7536 5 induced induce VBN cord-015021-pol2qm74 7536 6 ( ( -LRB- cord-015021-pol2qm74 7536 7 10 10 CD cord-015021-pol2qm74 7536 8 -7 -7 NNP cord-015021-pol2qm74 7536 9 reel reel NN cord-015021-pol2qm74 7536 10 / / SYM cord-015021-pol2qm74 7536 11 l l NN cord-015021-pol2qm74 7536 12 ) ) -RRB- cord-015021-pol2qm74 7536 13 neutrophil neutrophil NN cord-015021-pol2qm74 7536 14 oxygen oxygen NN cord-015021-pol2qm74 7536 15 radical radical JJ cord-015021-pol2qm74 7536 16 production production NN cord-015021-pol2qm74 7536 17 was be VBD cord-015021-pol2qm74 7536 18 significantly significantly RB cord-015021-pol2qm74 7536 19 increased increase VBN cord-015021-pol2qm74 7536 20 under under IN cord-015021-pol2qm74 7536 21 therapy therapy NN cord-015021-pol2qm74 7536 22 with with IN cord-015021-pol2qm74 7536 23 filgrastim filgrastim NN cord-015021-pol2qm74 7536 24 by by IN cord-015021-pol2qm74 7536 25 a a DT cord-015021-pol2qm74 7536 26 maximum maximum NN cord-015021-pol2qm74 7536 27 of of IN cord-015021-pol2qm74 7536 28 797 797 CD cord-015021-pol2qm74 7536 29 % % NN cord-015021-pol2qm74 7536 30 + + CC cord-015021-pol2qm74 7537 1 -570 -570 NNP cord-015021-pol2qm74 7537 2 % % NN cord-015021-pol2qm74 7537 3 ( ( -LRB- cord-015021-pol2qm74 7537 4 217 217 CD cord-015021-pol2qm74 7537 5 % % NN cord-015021-pol2qm74 7537 6 -1826 -1826 NN cord-015021-pol2qm74 7537 7 % % NN cord-015021-pol2qm74 7537 8 ) ) -RRB- cord-015021-pol2qm74 7537 9 compared compare VBN cord-015021-pol2qm74 7537 10 to to IN cord-015021-pol2qm74 7537 11 pretreatment pretreatment JJ cord-015021-pol2qm74 7537 12 values value NNS cord-015021-pol2qm74 7537 13 of of IN cord-015021-pol2qm74 7537 14 100 100 CD cord-015021-pol2qm74 7537 15 % % NN cord-015021-pol2qm74 7537 16 . . . cord-015021-pol2qm74 7538 1 Tapering taper VBG cord-015021-pol2qm74 7538 2 of of IN cord-015021-pol2qm74 7538 3 filgrastim filgrastim NN cord-015021-pol2qm74 7538 4 resulted result VBD cord-015021-pol2qm74 7538 5 in in IN cord-015021-pol2qm74 7538 6 a a DT cord-015021-pol2qm74 7538 7 reduction reduction NN cord-015021-pol2qm74 7538 8 of of IN cord-015021-pol2qm74 7538 9 FMLP FMLP NNP cord-015021-pol2qm74 7538 10 - - HYPH cord-015021-pol2qm74 7538 11 induced induce VBN cord-015021-pol2qm74 7538 12 neutrophil neutrophil NN cord-015021-pol2qm74 7538 13 oxygen oxygen NN cord-015021-pol2qm74 7538 14 radical radical JJ cord-015021-pol2qm74 7538 15 production production NN cord-015021-pol2qm74 7538 16 within within IN cord-015021-pol2qm74 7538 17 48 48 CD cord-015021-pol2qm74 7538 18 hours hour NNS cord-015021-pol2qm74 7538 19 . . . cord-015021-pol2qm74 7539 1 In in IN cord-015021-pol2qm74 7539 2 contrast contrast NN cord-015021-pol2qm74 7539 3 , , , cord-015021-pol2qm74 7539 4 zymosan zymosan NNP cord-015021-pol2qm74 7539 5 - - HYPH cord-015021-pol2qm74 7539 6 induced induce VBN cord-015021-pol2qm74 7539 7 neutrophil neutrophil NN cord-015021-pol2qm74 7539 8 oxygen oxygen NN cord-015021-pol2qm74 7539 9 radical radical JJ cord-015021-pol2qm74 7539 10 production production NN cord-015021-pol2qm74 7539 11 was be VBD cord-015021-pol2qm74 7539 12 not not RB cord-015021-pol2qm74 7539 13 affected affect VBN cord-015021-pol2qm74 7539 14 by by IN cord-015021-pol2qm74 7539 15 filgrastim filgrastim NN cord-015021-pol2qm74 7539 16 treatment treatment NN cord-015021-pol2qm74 7539 17 . . . cord-015021-pol2qm74 7540 1 CONCLUSIONS conclusion NNS cord-015021-pol2qm74 7540 2 : : : cord-015021-pol2qm74 7541 1 Besides besides IN cord-015021-pol2qm74 7541 2 its -PRON- PRP$ cord-015021-pol2qm74 7541 3 quantitative quantitative JJ cord-015021-pol2qm74 7541 4 effect effect NN cord-015021-pol2qm74 7541 5 on on IN cord-015021-pol2qm74 7541 6 neutrophil neutrophil NN cord-015021-pol2qm74 7541 7 counts count NNS cord-015021-pol2qm74 7541 8 enhanced enhance VBN cord-015021-pol2qm74 7541 9 neutrophil neutrophil NN cord-015021-pol2qm74 7541 10 function function NN cord-015021-pol2qm74 7541 11 , , , cord-015021-pol2qm74 7541 12 documented document VBN cord-015021-pol2qm74 7541 13 here here RB cord-015021-pol2qm74 7541 14 as as IN cord-015021-pol2qm74 7541 15 increased increase VBN cord-015021-pol2qm74 7541 16 FMLP FMLP NNP cord-015021-pol2qm74 7541 17 - - HYPH cord-015021-pol2qm74 7541 18 induced induce VBN cord-015021-pol2qm74 7541 19 oxygen oxygen NN cord-015021-pol2qm74 7541 20 radical radical JJ cord-015021-pol2qm74 7541 21 production production NN cord-015021-pol2qm74 7541 22 , , , cord-015021-pol2qm74 7541 23 may may MD cord-015021-pol2qm74 7541 24 account account VB cord-015021-pol2qm74 7541 25 for for IN cord-015021-pol2qm74 7541 26 the the DT cord-015021-pol2qm74 7541 27 beneficial beneficial JJ cord-015021-pol2qm74 7541 28 effect effect NN cord-015021-pol2qm74 7541 29 of of IN cord-015021-pol2qm74 7541 30 filgrastim filgrastim NN cord-015021-pol2qm74 7541 31 for for IN cord-015021-pol2qm74 7541 32 prophylaxis prophylaxis NN cord-015021-pol2qm74 7541 33 of of IN cord-015021-pol2qm74 7541 34 sepsis sepsis NN cord-015021-pol2qm74 7541 35 in in IN cord-015021-pol2qm74 7541 36 posttraumatic posttraumatic JJ cord-015021-pol2qm74 7541 37 / / SYM cord-015021-pol2qm74 7541 38 post post JJ cord-015021-pol2qm74 7541 39 - - JJ cord-015021-pol2qm74 7541 40 operative operative JJ cord-015021-pol2qm74 7541 41 patients patient NNS cord-015021-pol2qm74 7541 42 . . . cord-015021-pol2qm74 7542 1 Granulocyte Granulocyte NNP cord-015021-pol2qm74 7542 2 colony colony NN cord-015021-pol2qm74 7542 3 stimulating stimulate VBG cord-015021-pol2qm74 7542 4 factor factor NN cord-015021-pol2qm74 7542 5 ( ( -LRB- cord-015021-pol2qm74 7542 6 G G NNP cord-015021-pol2qm74 7542 7 - - HYPH cord-015021-pol2qm74 7542 8 CSF CSF NNP cord-015021-pol2qm74 7542 9 ) ) -RRB- cord-015021-pol2qm74 7542 10 and and CC cord-015021-pol2qm74 7542 11 granulocytemacrophage granulocytemacrophage NNP cord-015021-pol2qm74 7542 12 colony colony NN cord-015021-pol2qm74 7542 13 stimulating stimulate VBG cord-015021-pol2qm74 7542 14 factor factor NN cord-015021-pol2qm74 7542 15 ( ( -LRB- cord-015021-pol2qm74 7542 16 GM GM NNP cord-015021-pol2qm74 7542 17 - - HYPH cord-015021-pol2qm74 7542 18 CSF CSF NNP cord-015021-pol2qm74 7542 19 ) ) -RRB- cord-015021-pol2qm74 7542 20 have have VBP cord-015021-pol2qm74 7542 21 been be VBN cord-015021-pol2qm74 7542 22 recently recently RB cord-015021-pol2qm74 7542 23 introduced introduce VBN cord-015021-pol2qm74 7542 24 in in IN cord-015021-pol2qm74 7542 25 the the DT cord-015021-pol2qm74 7542 26 treatment treatment NN cord-015021-pol2qm74 7542 27 of of IN cord-015021-pol2qm74 7542 28 chemotherapy chemotherapy NN cord-015021-pol2qm74 7542 29 - - HYPH cord-015021-pol2qm74 7542 30 induced induce VBN cord-015021-pol2qm74 7542 31 neutropenia neutropenia NN cord-015021-pol2qm74 7542 32 . . . cord-015021-pol2qm74 7543 1 Effects effect NNS cord-015021-pol2qm74 7543 2 of of IN cord-015021-pol2qm74 7543 3 these these DT cord-015021-pol2qm74 7543 4 CSFs csf NNS cord-015021-pol2qm74 7543 5 on on IN cord-015021-pol2qm74 7543 6 cellular cellular JJ cord-015021-pol2qm74 7543 7 immune immune JJ cord-015021-pol2qm74 7543 8 system system NN cord-015021-pol2qm74 7543 9 were be VBD cord-015021-pol2qm74 7543 10 evaluated evaluate VBN cord-015021-pol2qm74 7543 11 in in IN cord-015021-pol2qm74 7543 12 38 38 CD cord-015021-pol2qm74 7543 13 neutropenic neutropenic JJ cord-015021-pol2qm74 7543 14 gynecological gynecological JJ cord-015021-pol2qm74 7543 15 cancer cancer NN cord-015021-pol2qm74 7543 16 patients patient NNS cord-015021-pol2qm74 7543 17 during during IN cord-015021-pol2qm74 7543 18 chemotherapy chemotherapy NN cord-015021-pol2qm74 7543 19 . . . cord-015021-pol2qm74 7544 1 G G NNP cord-015021-pol2qm74 7544 2 - - HYPH cord-015021-pol2qm74 7544 3 CSF CSF NNP cord-015021-pol2qm74 7544 4 and and CC cord-015021-pol2qm74 7544 5 GM GM NNP cord-015021-pol2qm74 7544 6 - - HYPH cord-015021-pol2qm74 7544 7 CSF CSF NNP cord-015021-pol2qm74 7544 8 were be VBD cord-015021-pol2qm74 7544 9 equally equally RB cord-015021-pol2qm74 7544 10 able able JJ cord-015021-pol2qm74 7544 11 to to TO cord-015021-pol2qm74 7544 12 induce induce VB cord-015021-pol2qm74 7544 13 a a DT cord-015021-pol2qm74 7544 14 rapid rapid JJ cord-015021-pol2qm74 7544 15 recovery recovery NN cord-015021-pol2qm74 7544 16 of of IN cord-015021-pol2qm74 7544 17 white white JJ cord-015021-pol2qm74 7544 18 cell cell NN cord-015021-pol2qm74 7544 19 count count NN cord-015021-pol2qm74 7544 20 within within IN cord-015021-pol2qm74 7544 21 one one CD cord-015021-pol2qm74 7544 22 or or CC cord-015021-pol2qm74 7544 23 two two CD cord-015021-pol2qm74 7544 24 days day NNS cord-015021-pol2qm74 7544 25 . . . cord-015021-pol2qm74 7545 1 G G NNP cord-015021-pol2qm74 7545 2 - - HYPH cord-015021-pol2qm74 7545 3 CSF CSF NNP cord-015021-pol2qm74 7545 4 treatment treatment NN cord-015021-pol2qm74 7545 5 resulted result VBD cord-015021-pol2qm74 7545 6 in in IN cord-015021-pol2qm74 7545 7 a a DT cord-015021-pol2qm74 7545 8 significantly significantly RB cord-015021-pol2qm74 7545 9 higher high JJR cord-015021-pol2qm74 7545 10 concentration concentration NN cord-015021-pol2qm74 7545 11 of of IN cord-015021-pol2qm74 7545 12 leukocytes leukocyte NNS cord-015021-pol2qm74 7545 13 measured measure VBN cord-015021-pol2qm74 7545 14 in in IN cord-015021-pol2qm74 7545 15 the the DT cord-015021-pol2qm74 7545 16 peripheral peripheral JJ cord-015021-pol2qm74 7545 17 blood blood NN cord-015021-pol2qm74 7545 18 although although IN cord-015021-pol2qm74 7545 19 by by IN cord-015021-pol2qm74 7545 20 GM GM NNP cord-015021-pol2qm74 7545 21 - - HYPH cord-015021-pol2qm74 7545 22 CSF CSF NNP cord-015021-pol2qm74 7545 23 a a DT cord-015021-pol2qm74 7545 24 sufficient sufficient JJ cord-015021-pol2qm74 7545 25 effect effect NN cord-015021-pol2qm74 7545 26 was be VBD cord-015021-pol2qm74 7545 27 achieved achieve VBN cord-015021-pol2qm74 7545 28 ( ( -LRB- cord-015021-pol2qm74 7545 29 p<0.05 p<0.05 CD cord-015021-pol2qm74 7545 30 ) ) -RRB- cord-015021-pol2qm74 7545 31 . . . cord-015021-pol2qm74 7546 1 Before before IN cord-015021-pol2qm74 7546 2 initiation initiation NN cord-015021-pol2qm74 7546 3 of of IN cord-015021-pol2qm74 7546 4 CSF CSF NNP cord-015021-pol2qm74 7546 5 treatment treatment NN cord-015021-pol2qm74 7546 6 urinary urinary JJ cord-015021-pol2qm74 7546 7 neopterin neopterin NNP cord-015021-pol2qm74 7546 8 was be VBD cord-015021-pol2qm74 7546 9 similar similar JJ cord-015021-pol2qm74 7546 10 in in IN cord-015021-pol2qm74 7546 11 both both DT cord-015021-pol2qm74 7546 12 groups group NNS cord-015021-pol2qm74 7546 13 of of IN cord-015021-pol2qm74 7546 14 patients patient NNS cord-015021-pol2qm74 7546 15 ( ( -LRB- cord-015021-pol2qm74 7546 16 283+/-38 283+/-38 CD cord-015021-pol2qm74 7546 17 and and CC cord-015021-pol2qm74 7546 18 267+/-40 267+/-40 CD cord-015021-pol2qm74 7546 19 lamol lamol JJ cord-015021-pol2qm74 7546 20 / / SYM cord-015021-pol2qm74 7546 21 mol mol NN cord-015021-pol2qm74 7546 22 creatinine creatinine NN cord-015021-pol2qm74 7546 23 for for IN cord-015021-pol2qm74 7546 24 GM GM NNP cord-015021-pol2qm74 7546 25 - - HYPH cord-015021-pol2qm74 7546 26 CSF CSF NNP cord-015021-pol2qm74 7546 27 and and CC cord-015021-pol2qm74 7546 28 G G NNP cord-015021-pol2qm74 7546 29 - - HYPH cord-015021-pol2qm74 7546 30 CSF CSF NNP cord-015021-pol2qm74 7546 31 respectively respectively RB cord-015021-pol2qm74 7546 32 expressed express VBD cord-015021-pol2qm74 7546 33 as as IN cord-015021-pol2qm74 7546 34 mean mean NN cord-015021-pol2qm74 7546 35 + + CC cord-015021-pol2qm74 7546 36 /-one /-one CD cord-015021-pol2qm74 7546 37 SD sd NN cord-015021-pol2qm74 7546 38 ) ) -RRB- cord-015021-pol2qm74 7546 39 . . . cord-015021-pol2qm74 7547 1 In in IN cord-015021-pol2qm74 7547 2 G G NNP cord-015021-pol2qm74 7547 3 - - HYPH cord-015021-pol2qm74 7547 4 CSF csf NN cord-015021-pol2qm74 7547 5 treated treat VBN cord-015021-pol2qm74 7547 6 patient patient NN cord-015021-pol2qm74 7547 7 only only RB cord-015021-pol2qm74 7547 8 a a DT cord-015021-pol2qm74 7547 9 marginal marginal JJ cord-015021-pol2qm74 7547 10 induction induction NN cord-015021-pol2qm74 7547 11 of of IN cord-015021-pol2qm74 7547 12 neopterin neopterin NNP cord-015021-pol2qm74 7547 13 was be VBD cord-015021-pol2qm74 7547 14 observed observe VBN cord-015021-pol2qm74 7547 15 . . . cord-015021-pol2qm74 7548 1 On on IN cord-015021-pol2qm74 7548 2 day day NN cord-015021-pol2qm74 7548 3 4 4 CD cord-015021-pol2qm74 7548 4 the the DT cord-015021-pol2qm74 7548 5 mean mean JJ cord-015021-pol2qm74 7548 6 value value NN cord-015021-pol2qm74 7548 7 was be VBD cord-015021-pol2qm74 7548 8 about about RB cord-015021-pol2qm74 7548 9 40 40 CD cord-015021-pol2qm74 7548 10 % % NN cord-015021-pol2qm74 7548 11 above above IN cord-015021-pol2qm74 7548 12 the the DT cord-015021-pol2qm74 7548 13 basal basal NN cord-015021-pol2qm74 7548 14 level level NN cord-015021-pol2qm74 7548 15 ( ( -LRB- cord-015021-pol2qm74 7548 16 p<0.05 p<0.05 CD cord-015021-pol2qm74 7548 17 ) ) -RRB- cord-015021-pol2qm74 7548 18 . . . cord-015021-pol2qm74 7549 1 On on IN cord-015021-pol2qm74 7549 2 the the DT cord-015021-pol2qm74 7549 3 other other JJ cord-015021-pol2qm74 7549 4 hand hand NN cord-015021-pol2qm74 7549 5 GM GM NNP cord-015021-pol2qm74 7549 6 - - HYPH cord-015021-pol2qm74 7549 7 CSF CSF NNP cord-015021-pol2qm74 7549 8 treated treat VBD cord-015021-pol2qm74 7549 9 patients patient NNS cord-015021-pol2qm74 7549 10 were be VBD cord-015021-pol2qm74 7549 11 characterized characterize VBN cord-015021-pol2qm74 7549 12 by by IN cord-015021-pol2qm74 7549 13 a a DT cord-015021-pol2qm74 7549 14 pronounced pronounced JJ cord-015021-pol2qm74 7549 15 increase increase NN cord-015021-pol2qm74 7549 16 in in IN cord-015021-pol2qm74 7549 17 urinary urinary JJ cord-015021-pol2qm74 7549 18 neopterin neopterin JJ cord-015021-pol2qm74 7549 19 levels level NNS cord-015021-pol2qm74 7549 20 . . . cord-015021-pol2qm74 7550 1 In in IN cord-015021-pol2qm74 7550 2 comparison comparison NN cord-015021-pol2qm74 7550 3 with with IN cord-015021-pol2qm74 7550 4 the the DT cord-015021-pol2qm74 7550 5 basal basal NN cord-015021-pol2qm74 7550 6 level level NN cord-015021-pol2qm74 7550 7 a a DT cord-015021-pol2qm74 7550 8 more more JJR cord-015021-pol2qm74 7550 9 than than IN cord-015021-pol2qm74 7550 10 2 2 CD cord-015021-pol2qm74 7550 11 fold fold NN cord-015021-pol2qm74 7550 12 induction induction NN cord-015021-pol2qm74 7550 13 was be VBD cord-015021-pol2qm74 7550 14 noted note VBN cord-015021-pol2qm74 7550 15 and and CC cord-015021-pol2qm74 7550 16 the the DT cord-015021-pol2qm74 7550 17 difference difference NN cord-015021-pol2qm74 7550 18 between between IN cord-015021-pol2qm74 7550 19 G G NNP cord-015021-pol2qm74 7550 20 - - HYPH cord-015021-pol2qm74 7550 21 CSF CSF NNP cord-015021-pol2qm74 7550 22 and and CC cord-015021-pol2qm74 7550 23 GM GM NNP cord-015021-pol2qm74 7550 24 - - HYPH cord-015021-pol2qm74 7550 25 CSF CSF NNP cord-015021-pol2qm74 7550 26 was be VBD cord-015021-pol2qm74 7550 27 highly highly RB cord-015021-pol2qm74 7550 28 significant significant JJ cord-015021-pol2qm74 7550 29 ( ( -LRB- cord-015021-pol2qm74 7550 30 p<0.01 p<0.01 NNP cord-015021-pol2qm74 7550 31 ) ) -RRB- cord-015021-pol2qm74 7550 32 . . . cord-015021-pol2qm74 7551 1 This this DT cord-015021-pol2qm74 7551 2 effect effect NN cord-015021-pol2qm74 7551 3 was be VBD cord-015021-pol2qm74 7551 4 confirmed confirm VBN cord-015021-pol2qm74 7551 5 in in IN cord-015021-pol2qm74 7551 6 vitro vitro FW cord-015021-pol2qm74 7551 7 by by IN cord-015021-pol2qm74 7551 8 investigating investigate VBG cord-015021-pol2qm74 7551 9 the the DT cord-015021-pol2qm74 7551 10 effects effect NNS cord-015021-pol2qm74 7551 11 of of IN cord-015021-pol2qm74 7551 12 these these DT cord-015021-pol2qm74 7551 13 CSFs csf NNS cord-015021-pol2qm74 7551 14 on on IN cord-015021-pol2qm74 7551 15 interferon interferon NN cord-015021-pol2qm74 7551 16 - - HYPH cord-015021-pol2qm74 7551 17 gamma gamma NN cord-015021-pol2qm74 7551 18 mediated mediate VBN cord-015021-pol2qm74 7551 19 pathways pathway NNS cord-015021-pol2qm74 7551 20 in in IN cord-015021-pol2qm74 7551 21 THP-1 THP-1 NNP cord-015021-pol2qm74 7551 22 human human JJ cord-015021-pol2qm74 7551 23 myelomonocytic myelomonocytic NN cord-015021-pol2qm74 7551 24 cells cell NNS cord-015021-pol2qm74 7551 25 . . . cord-015021-pol2qm74 7552 1 Results result NNS cord-015021-pol2qm74 7552 2 suggest suggest VBP cord-015021-pol2qm74 7552 3 activation activation NN cord-015021-pol2qm74 7552 4 of of IN cord-015021-pol2qm74 7552 5 immune immune JJ cord-015021-pol2qm74 7552 6 effector effector NN cord-015021-pol2qm74 7552 7 cells cell NNS cord-015021-pol2qm74 7552 8 by by IN cord-015021-pol2qm74 7552 9 GM GM NNP cord-015021-pol2qm74 7552 10 - - HYPH cord-015021-pol2qm74 7552 11 CSF CSF NNP cord-015021-pol2qm74 7552 12 which which WDT cord-015021-pol2qm74 7552 13 may may MD cord-015021-pol2qm74 7552 14 help help VB cord-015021-pol2qm74 7552 15 the the DT cord-015021-pol2qm74 7552 16 organism organism NN cord-015021-pol2qm74 7552 17 to to TO cord-015021-pol2qm74 7552 18 overcome overcome VB cord-015021-pol2qm74 7552 19 infections infection NNS cord-015021-pol2qm74 7552 20 . . . cord-015021-pol2qm74 7553 1 However however RB cord-015021-pol2qm74 7553 2 , , , cord-015021-pol2qm74 7553 3 activated activate VBN cord-015021-pol2qm74 7553 4 macrophages macrophage NNS cord-015021-pol2qm74 7553 5 produce produce VBP cord-015021-pol2qm74 7553 6 several several JJ cord-015021-pol2qm74 7553 7 growth growth NN cord-015021-pol2qm74 7553 8 factors factor NNS cord-015021-pol2qm74 7553 9 which which WDT cord-015021-pol2qm74 7553 10 may may MD cord-015021-pol2qm74 7553 11 increase increase VB cord-015021-pol2qm74 7553 12 malignant malignant JJ cord-015021-pol2qm74 7553 13 proliferation proliferation NN cord-015021-pol2qm74 7553 14 , , , cord-015021-pol2qm74 7553 15 and and CC cord-015021-pol2qm74 7553 16 augmented augment VBN cord-015021-pol2qm74 7553 17 neopterin neopterin JJ cord-015021-pol2qm74 7553 18 production production NN cord-015021-pol2qm74 7553 19 as as IN cord-015021-pol2qm74 7553 20 sign sign NN cord-015021-pol2qm74 7553 21 of of IN cord-015021-pol2qm74 7553 22 macrophage macrophage NN cord-015021-pol2qm74 7553 23 activation activation NN cord-015021-pol2qm74 7553 24 has have VBZ cord-015021-pol2qm74 7553 25 also also RB cord-015021-pol2qm74 7553 26 been be VBN cord-015021-pol2qm74 7553 27 associated associate VBN cord-015021-pol2qm74 7553 28 with with IN cord-015021-pol2qm74 7553 29 poor poor JJ cord-015021-pol2qm74 7553 30 prognosis prognosis NN cord-015021-pol2qm74 7553 31 m m CD cord-015021-pol2qm74 7553 32 several several JJ cord-015021-pol2qm74 7553 33 malignancies malignancy NNS cord-015021-pol2qm74 7553 34 . . . cord-015021-pol2qm74 7554 1 More More JJR cord-015021-pol2qm74 7554 2 data datum NNS cord-015021-pol2qm74 7554 3 are be VBP cord-015021-pol2qm74 7554 4 therefore therefore RB cord-015021-pol2qm74 7554 5 necessary necessary JJ cord-015021-pol2qm74 7554 6 to to TO cord-015021-pol2qm74 7554 7 clarify clarify VB cord-015021-pol2qm74 7554 8 whether whether IN cord-015021-pol2qm74 7554 9 CSF CSF NNP cord-015021-pol2qm74 7554 10 mediated mediate VBD cord-015021-pol2qm74 7554 11 immune immune JJ cord-015021-pol2qm74 7554 12 activation activation NN cord-015021-pol2qm74 7554 13 is be VBZ cord-015021-pol2qm74 7554 14 beneficial beneficial JJ cord-015021-pol2qm74 7554 15 or or CC cord-015021-pol2qm74 7554 16 deleterious deleterious JJ cord-015021-pol2qm74 7554 17 for for IN cord-015021-pol2qm74 7554 18 cancer cancer NN cord-015021-pol2qm74 7554 19 patients patient NNS cord-015021-pol2qm74 7554 20 but but CC cord-015021-pol2qm74 7554 21 considering consider VBG cord-015021-pol2qm74 7554 22 our -PRON- PRP$ cord-015021-pol2qm74 7554 23 results result NNS cord-015021-pol2qm74 7554 24 caution caution NN cord-015021-pol2qm74 7554 25 in in IN cord-015021-pol2qm74 7554 26 applying apply VBG cord-015021-pol2qm74 7554 27 CSFs CSFs NNP cord-015021-pol2qm74 7554 28 in in IN cord-015021-pol2qm74 7554 29 oncology oncology NN cord-015021-pol2qm74 7554 30 seems seem VBZ cord-015021-pol2qm74 7554 31 advised advise VBN cord-015021-pol2qm74 7554 32 . . . cord-015021-pol2qm74 7555 1 From from IN cord-015021-pol2qm74 7555 2 a a DT cord-015021-pol2qm74 7555 3 historical historical JJ cord-015021-pol2qm74 7555 4 perspective perspective NN cord-015021-pol2qm74 7555 5 , , , cord-015021-pol2qm74 7555 6 the the DT cord-015021-pol2qm74 7555 7 development development NN cord-015021-pol2qm74 7555 8 of of IN cord-015021-pol2qm74 7555 9 humoral humoral JJ cord-015021-pol2qm74 7555 10 immunity immunity NN cord-015021-pol2qm74 7555 11 to to IN cord-015021-pol2qm74 7555 12 bacterial bacterial JJ cord-015021-pol2qm74 7555 13 endotoxin endotoxin NN cord-015021-pol2qm74 7555 14 has have VBZ cord-015021-pol2qm74 7555 15 assumed assume VBN cord-015021-pol2qm74 7555 16 a a DT cord-015021-pol2qm74 7555 17 prominent prominent JJ cord-015021-pol2qm74 7555 18 position position NN cord-015021-pol2qm74 7555 19 in in IN cord-015021-pol2qm74 7555 20 the the DT cord-015021-pol2qm74 7555 21 spectrum spectrum NN cord-015021-pol2qm74 7555 22 of of IN cord-015021-pol2qm74 7555 23 therapeutic therapeutic JJ cord-015021-pol2qm74 7555 24 approaches approach NNS cord-015021-pol2qm74 7555 25 which which WDT cord-015021-pol2qm74 7555 26 have have VBP cord-015021-pol2qm74 7555 27 been be VBN cord-015021-pol2qm74 7555 28 explored explore VBN cord-015021-pol2qm74 7555 29 for for IN cord-015021-pol2qm74 7555 30 the the DT cord-015021-pol2qm74 7555 31 treatment treatment NN cord-015021-pol2qm74 7555 32 of of IN cord-015021-pol2qm74 7555 33 Gram Gram NNP cord-015021-pol2qm74 7555 34 negative negative JJ cord-015021-pol2qm74 7555 35 septic septic JJ cord-015021-pol2qm74 7555 36 shock shock NN cord-015021-pol2qm74 7555 37 . . . cord-015021-pol2qm74 7556 1 Predicated predicate VBN cord-015021-pol2qm74 7556 2 upon upon IN cord-015021-pol2qm74 7556 3 the the DT cord-015021-pol2qm74 7556 4 fact fact NN cord-015021-pol2qm74 7556 5 that that IN cord-015021-pol2qm74 7556 6 rough rough JJ cord-015021-pol2qm74 7556 7 strains strain NNS cord-015021-pol2qm74 7556 8 of of IN cord-015021-pol2qm74 7556 9 bacteria bacteria NNS cord-015021-pol2qm74 7556 10 manifest manifest VBP cord-015021-pol2qm74 7556 11 LPS LPS NNP cord-015021-pol2qm74 7556 12 containing contain VBG cord-015021-pol2qm74 7556 13 exclusively exclusively RB cord-015021-pol2qm74 7556 14 conserved conserve VBN cord-015021-pol2qm74 7556 15 structural structural JJ cord-015021-pol2qm74 7556 16 features feature NNS cord-015021-pol2qm74 7556 17 common common JJ cord-015021-pol2qm74 7556 18 to to IN cord-015021-pol2qm74 7556 19 LPS lp NNS cord-015021-pol2qm74 7556 20 from from IN cord-015021-pol2qm74 7556 21 all all DT cord-015021-pol2qm74 7556 22 Gram Gram NNP cord-015021-pol2qm74 7556 23 negatives negative NNS cord-015021-pol2qm74 7556 24 , , , cord-015021-pol2qm74 7556 25 specific specific JJ cord-015021-pol2qm74 7556 26 antibodies antibody NNS cord-015021-pol2qm74 7556 27 were be VBD cord-015021-pol2qm74 7556 28 elicited elicit VBN cord-015021-pol2qm74 7556 29 which which WDT cord-015021-pol2qm74 7556 30 conveyed convey VBD cord-015021-pol2qm74 7556 31 cross cross JJ cord-015021-pol2qm74 7556 32 protective protective JJ cord-015021-pol2qm74 7556 33 immunity immunity NN cord-015021-pol2qm74 7556 34 in in IN cord-015021-pol2qm74 7556 35 experimental experimental JJ cord-015021-pol2qm74 7556 36 models model NNS cord-015021-pol2qm74 7556 37 of of IN cord-015021-pol2qm74 7556 38 bacteremia bacteremia NN cord-015021-pol2qm74 7556 39 and and CC cord-015021-pol2qm74 7556 40 endotoxemia endotoxemia NN cord-015021-pol2qm74 7556 41 . . . cord-015021-pol2qm74 7557 1 Such such JJ cord-015021-pol2qm74 7557 2 studies study NNS cord-015021-pol2qm74 7557 3 culminated culminate VBD cord-015021-pol2qm74 7557 4 in in IN cord-015021-pol2qm74 7557 5 a a DT cord-015021-pol2qm74 7557 6 well well RB cord-015021-pol2qm74 7557 7 - - HYPH cord-015021-pol2qm74 7557 8 conducted conduct VBN cord-015021-pol2qm74 7557 9 , , , cord-015021-pol2qm74 7557 10 randomized randomized JJ cord-015021-pol2qm74 7557 11 , , , cord-015021-pol2qm74 7557 12 double double JJ cord-015021-pol2qm74 7557 13 - - HYPH cord-015021-pol2qm74 7557 14 blind blind JJ cord-015021-pol2qm74 7557 15 placebo placebo NN cord-015021-pol2qm74 7557 16 - - HYPH cord-015021-pol2qm74 7557 17 controlled control VBN cord-015021-pol2qm74 7557 18 clinical clinical JJ cord-015021-pol2qm74 7557 19 trial trial NN cord-015021-pol2qm74 7557 20 using use VBG cord-015021-pol2qm74 7557 21 passively passively RB cord-015021-pol2qm74 7557 22 administered administer VBN cord-015021-pol2qm74 7557 23 human human JJ cord-015021-pol2qm74 7557 24 polyclonal polyclonal JJ cord-015021-pol2qm74 7557 25 antiserum antiserum NN cord-015021-pol2qm74 7557 26 to to TO cord-015021-pol2qm74 7557 27 treat treat VB cord-015021-pol2qm74 7557 28 patients patient NNS cord-015021-pol2qm74 7557 29 with with IN cord-015021-pol2qm74 7557 30 suspected suspect VBN cord-015021-pol2qm74 7557 31 Gram Gram NNP cord-015021-pol2qm74 7557 32 negative negative JJ cord-015021-pol2qm74 7557 33 sepsis sepsis NN cord-015021-pol2qm74 7557 34 . . . cord-015021-pol2qm74 7558 1 The the DT cord-015021-pol2qm74 7558 2 efficacy efficacy NN cord-015021-pol2qm74 7558 3 of of IN cord-015021-pol2qm74 7558 4 treatment treatment NN cord-015021-pol2qm74 7558 5 established establish VBN cord-015021-pol2qm74 7558 6 in in IN cord-015021-pol2qm74 7558 7 that that DT cord-015021-pol2qm74 7558 8 trial trial NN cord-015021-pol2qm74 7558 9 spurred spur VBD cord-015021-pol2qm74 7558 10 efforts effort NNS cord-015021-pol2qm74 7558 11 to to TO cord-015021-pol2qm74 7558 12 develop develop VB cord-015021-pol2qm74 7558 13 monoclonai monoclonai JJ cord-015021-pol2qm74 7558 14 reagents reagent NNS cord-015021-pol2qm74 7558 15 which which WDT cord-015021-pol2qm74 7558 16 , , , cord-015021-pol2qm74 7558 17 to to IN cord-015021-pol2qm74 7558 18 date date NN cord-015021-pol2qm74 7558 19 , , , cord-015021-pol2qm74 7558 20 have have VBP cord-015021-pol2qm74 7558 21 not not RB cord-015021-pol2qm74 7558 22 been be VBN cord-015021-pol2qm74 7558 23 uniformly uniformly RB cord-015021-pol2qm74 7558 24 successful successful JJ cord-015021-pol2qm74 7558 25 in in IN cord-015021-pol2qm74 7558 26 reproducing reproduce VBG cord-015021-pol2qm74 7558 27 those those DT cord-015021-pol2qm74 7558 28 earlier early JJR cord-015021-pol2qm74 7558 29 studies study NNS cord-015021-pol2qm74 7558 30 with with IN cord-015021-pol2qm74 7558 31 polyclonai polyclonai NNP cord-015021-pol2qm74 7558 32 antibodies antibody NNS cord-015021-pol2qm74 7558 33 . . . cord-015021-pol2qm74 7559 1 Nevertheless nevertheless RB cord-015021-pol2qm74 7559 2 , , , cord-015021-pol2qm74 7559 3 the the DT cord-015021-pol2qm74 7559 4 numerous numerous JJ cord-015021-pol2qm74 7559 5 successes success NNS cord-015021-pol2qm74 7559 6 which which WDT cord-015021-pol2qm74 7559 7 have have VBP cord-015021-pol2qm74 7559 8 been be VBN cord-015021-pol2qm74 7559 9 documented document VBN cord-015021-pol2qm74 7559 10 in in IN cord-015021-pol2qm74 7559 11 experimental experimental JJ cord-015021-pol2qm74 7559 12 models model NNS cord-015021-pol2qm74 7559 13 of of IN cord-015021-pol2qm74 7559 14 endotoxemia endotoxemia NN cord-015021-pol2qm74 7559 15 continue continue VBP cord-015021-pol2qm74 7559 16 to to TO cord-015021-pol2qm74 7559 17 foster foster VB cord-015021-pol2qm74 7559 18 promise promise NN cord-015021-pol2qm74 7559 19 for for IN cord-015021-pol2qm74 7559 20 this this DT cord-015021-pol2qm74 7559 21 immunotherapeutie immunotherapeutie NN cord-015021-pol2qm74 7559 22 approach approach NN cord-015021-pol2qm74 7559 23 . . . cord-015021-pol2qm74 7560 1 Several several JJ cord-015021-pol2qm74 7560 2 recent recent JJ cord-015021-pol2qm74 7560 3 studies study NNS cord-015021-pol2qm74 7560 4 with with IN cord-015021-pol2qm74 7560 5 human human JJ cord-015021-pol2qm74 7560 6 polyclonalimrnunoglobulin polyclonalimrnunoglobulin NNP cord-015021-pol2qm74 7560 7 preparations preparation NNS cord-015021-pol2qm74 7560 8 containing contain VBG cord-015021-pol2qm74 7560 9 antibodies antibody NNS cord-015021-pol2qm74 7560 10 reactive reactive JJ cord-015021-pol2qm74 7560 11 with with IN cord-015021-pol2qm74 7560 12 LPS LPS NNP cord-015021-pol2qm74 7560 13 and and CC cord-015021-pol2qm74 7560 14 lipid lipid NN cord-015021-pol2qm74 7560 15 A a DT cord-015021-pol2qm74 7560 16 have have VBP cord-015021-pol2qm74 7560 17 yielded yield VBN cord-015021-pol2qm74 7560 18 promising promising JJ cord-015021-pol2qm74 7560 19 results result NNS cord-015021-pol2qm74 7560 20 in in IN cord-015021-pol2qm74 7560 21 treatment treatment NN cord-015021-pol2qm74 7560 22 of of IN cord-015021-pol2qm74 7560 23 patients patient NNS cord-015021-pol2qm74 7560 24 with with IN cord-015021-pol2qm74 7560 25 sepsis sepsis NN cord-015021-pol2qm74 7560 26 . . . cord-015021-pol2qm74 7561 1 In in IN cord-015021-pol2qm74 7561 2 addition addition NN cord-015021-pol2qm74 7561 3 , , , cord-015021-pol2qm74 7561 4 the the DT cord-015021-pol2qm74 7561 5 recent recent JJ cord-015021-pol2qm74 7561 6 development development NN cord-015021-pol2qm74 7561 7 of of IN cord-015021-pol2qm74 7561 8 an an DT cord-015021-pol2qm74 7561 9 antiidiotypic antiidiotypic JJ cord-015021-pol2qm74 7561 10 monoclonal monoclonal JJ cord-015021-pol2qm74 7561 11 antibody antibody NN cord-015021-pol2qm74 7561 12 which which WDT cord-015021-pol2qm74 7561 13 reflects reflect VBZ cord-015021-pol2qm74 7561 14 an an DT cord-015021-pol2qm74 7561 15 internal internal JJ cord-015021-pol2qm74 7561 16 image image NN cord-015021-pol2qm74 7561 17 of of IN cord-015021-pol2qm74 7561 18 a a DT cord-015021-pol2qm74 7561 19 kDO kdo XX cord-015021-pol2qm74 7561 20 specific specific JJ cord-015021-pol2qm74 7561 21 monoclonal monoclonal JJ cord-015021-pol2qm74 7561 22 antibody antibody NN cord-015021-pol2qm74 7561 23 has have VBZ cord-015021-pol2qm74 7561 24 provided provide VBN cord-015021-pol2qm74 7561 25 an an DT cord-015021-pol2qm74 7561 26 alternative alternative JJ cord-015021-pol2qm74 7561 27 experimental experimental JJ cord-015021-pol2qm74 7561 28 approach approach NN cord-015021-pol2qm74 7561 29 to to TO cord-015021-pol2qm74 7561 30 generate generate VB cord-015021-pol2qm74 7561 31 anti anti JJ cord-015021-pol2qm74 7561 32 - - JJ cord-015021-pol2qm74 7561 33 LPS lps JJ cord-015021-pol2qm74 7561 34 antibody antibody NN cord-015021-pol2qm74 7561 35 . . . cord-015021-pol2qm74 7562 1 Immunization immunization NN cord-015021-pol2qm74 7562 2 of of IN cord-015021-pol2qm74 7562 3 mice mouse NNS cord-015021-pol2qm74 7562 4 with with IN cord-015021-pol2qm74 7562 5 the the DT cord-015021-pol2qm74 7562 6 antiidiotype antiidiotype NNP cord-015021-pol2qm74 7562 7 provides provide VBZ cord-015021-pol2qm74 7562 8 significant significant JJ cord-015021-pol2qm74 7562 9 protection protection NN cord-015021-pol2qm74 7562 10 against against IN cord-015021-pol2qm74 7562 11 subsequent subsequent JJ cord-015021-pol2qm74 7562 12 LPS LPS NNP cord-015021-pol2qm74 7562 13 lethality lethality NN cord-015021-pol2qm74 7562 14 consistent consistent JJ cord-015021-pol2qm74 7562 15 with with IN cord-015021-pol2qm74 7562 16 the the DT cord-015021-pol2qm74 7562 17 development development NN cord-015021-pol2qm74 7562 18 of of IN cord-015021-pol2qm74 7562 19 circulating circulate VBG cord-015021-pol2qm74 7562 20 immunoglobulin immunoglobulin NN cord-015021-pol2qm74 7562 21 specific specific JJ cord-015021-pol2qm74 7562 22 for for IN cord-015021-pol2qm74 7562 23 LPS lp NNS cord-015021-pol2qm74 7562 24 . . . cord-015021-pol2qm74 7563 1 Thus thus RB cord-015021-pol2qm74 7563 2 , , , cord-015021-pol2qm74 7563 3 the the DT cord-015021-pol2qm74 7563 4 use use NN cord-015021-pol2qm74 7563 5 of of IN cord-015021-pol2qm74 7563 6 polyclonal polyclonal JJ cord-015021-pol2qm74 7563 7 immunoglobulins immunoglobulin NNS cord-015021-pol2qm74 7563 8 contrives contrive VBZ cord-015021-pol2qm74 7563 9 to to TO cord-015021-pol2qm74 7563 10 provide provide VB cord-015021-pol2qm74 7563 11 an an DT cord-015021-pol2qm74 7563 12 alternative alternative NN cord-015021-pol2qm74 7563 13 and and CC cord-015021-pol2qm74 7563 14 potentially potentially RB cord-015021-pol2qm74 7563 15 cost cost VB cord-015021-pol2qm74 7563 16 effective effective JJ cord-015021-pol2qm74 7563 17 method method NN cord-015021-pol2qm74 7563 18 for for IN cord-015021-pol2qm74 7563 19 the the DT cord-015021-pol2qm74 7563 20 treatment treatment NN cord-015021-pol2qm74 7563 21 of of IN cord-015021-pol2qm74 7563 22 endotoxin endotoxin NN cord-015021-pol2qm74 7563 23 shock shock NN cord-015021-pol2qm74 7563 24 . . . cord-015021-pol2qm74 7564 1 Supported support VBN cord-015021-pol2qm74 7564 2 by by IN cord-015021-pol2qm74 7564 3 R37 R37 NNP cord-015021-pol2qm74 7564 4 A123447 A123447 NNP cord-015021-pol2qm74 7564 5 and and CC cord-015021-pol2qm74 7564 6 POt POt NNP cord-015021-pol2qm74 7564 7 CA54474 CA54474 NNP cord-015021-pol2qm74 7564 8 . . . cord-015021-pol2qm74 7565 1 John John NNP cord-015021-pol2qm74 7565 2 Holaday Holaday NNP cord-015021-pol2qm74 7565 3 , , , cord-015021-pol2qm74 7565 4 Anne Anne NNP cord-015021-pol2qm74 7565 5 Fortier Fortier NNP cord-015021-pol2qm74 7565 6 , , , cord-015021-pol2qm74 7565 7 Shawn Shawn NNP cord-015021-pol2qm74 7565 8 Green Green NNP cord-015021-pol2qm74 7565 9 , , , cord-015021-pol2qm74 7565 10 Glenn Glenn NNP cord-015021-pol2qm74 7565 11 Swartz Swartz NNP cord-015021-pol2qm74 7565 12 , , , cord-015021-pol2qm74 7565 13 John John NNP cord-015021-pol2qm74 7565 14 Madsen Madsen NNP cord-015021-pol2qm74 7565 15 , , , cord-015021-pol2qm74 7565 16 Carol Carol NNP cord-015021-pol2qm74 7565 17 Naey Naey NNP cord-015021-pol2qm74 7565 18 , , , cord-015021-pol2qm74 7565 19 and and CC cord-015021-pol2qm74 7565 20 Jan Jan NNP cord-015021-pol2qm74 7565 21 DiJkstra DiJkstra NNP cord-015021-pol2qm74 7565 22 EntreMed EntreMed NNP cord-015021-pol2qm74 7565 23 , , , cord-015021-pol2qm74 7565 24 Inc Inc NNP cord-015021-pol2qm74 7565 25 .. .. NFP cord-015021-pol2qm74 7565 26 Rockville Rockville NNP cord-015021-pol2qm74 7565 27 , , , cord-015021-pol2qm74 7565 28 MD MD NNP cord-015021-pol2qm74 7565 29 , , , cord-015021-pol2qm74 7565 30 20850 20850 CD cord-015021-pol2qm74 7565 31 . . . cord-015021-pol2qm74 7566 1 At at IN cord-015021-pol2qm74 7566 2 the the DT cord-015021-pol2qm74 7566 3 time time NN cord-015021-pol2qm74 7566 4 of of IN cord-015021-pol2qm74 7566 5 diagnosis diagnosis NN cord-015021-pol2qm74 7566 6 , , , cord-015021-pol2qm74 7566 7 the the DT cord-015021-pol2qm74 7566 8 signs sign NNS cord-015021-pol2qm74 7566 9 and and CC cord-015021-pol2qm74 7566 10 symptoms symptom NNS cord-015021-pol2qm74 7566 11 of of IN cord-015021-pol2qm74 7566 12 septic septic JJ cord-015021-pol2qm74 7566 13 shock shock NN cord-015021-pol2qm74 7566 14 are be VBP cord-015021-pol2qm74 7566 15 an an DT cord-015021-pol2qm74 7566 16 indication indication NN cord-015021-pol2qm74 7566 17 that that IN cord-015021-pol2qm74 7566 18 the the DT cord-015021-pol2qm74 7566 19 systemic systemic JJ cord-015021-pol2qm74 7566 20 inflammatory inflammatory JJ cord-015021-pol2qm74 7566 21 response response NN cord-015021-pol2qm74 7566 22 is be VBZ cord-015021-pol2qm74 7566 23 well well RB cord-015021-pol2qm74 7566 24 underway underway JJ cord-015021-pol2qm74 7566 25 ; ; : cord-015021-pol2qm74 7566 26 thus thus RB cord-015021-pol2qm74 7566 27 , , , cord-015021-pol2qm74 7566 28 it -PRON- PRP cord-015021-pol2qm74 7566 29 has have VBZ cord-015021-pol2qm74 7566 30 been be VBN cord-015021-pol2qm74 7566 31 argued argue VBN cord-015021-pol2qm74 7566 32 that that IN cord-015021-pol2qm74 7566 33 the the DT cord-015021-pol2qm74 7566 34 endotoxin endotoxin NN cord-015021-pol2qm74 7566 35 " " '' cord-015021-pol2qm74 7566 36 cat cat NN cord-015021-pol2qm74 7566 37 is be VBZ cord-015021-pol2qm74 7566 38 out out IN cord-015021-pol2qm74 7566 39 of of IN cord-015021-pol2qm74 7566 40 the the DT cord-015021-pol2qm74 7566 41 bag bag NN cord-015021-pol2qm74 7566 42 " " '' cord-015021-pol2qm74 7566 43 , , , cord-015021-pol2qm74 7566 44 and and CC cord-015021-pol2qm74 7566 45 that that IN cord-015021-pol2qm74 7566 46 subsequent subsequent JJ cord-015021-pol2qm74 7566 47 passive passive JJ cord-015021-pol2qm74 7566 48 immunization immunization NN cord-015021-pol2qm74 7566 49 may may MD cord-015021-pol2qm74 7566 50 be be VB cord-015021-pol2qm74 7566 51 too too RB cord-015021-pol2qm74 7566 52 late late JJ cord-015021-pol2qm74 7566 53 to to TO cord-015021-pol2qm74 7566 54 achieve achieve VB cord-015021-pol2qm74 7566 55 therapeutic therapeutic JJ cord-015021-pol2qm74 7566 56 benefit benefit NN cord-015021-pol2qm74 7566 57 . . . cord-015021-pol2qm74 7567 1 Our -PRON- PRP$ cord-015021-pol2qm74 7567 2 approach approach NN cord-015021-pol2qm74 7567 3 has have VBZ cord-015021-pol2qm74 7567 4 been be VBN cord-015021-pol2qm74 7567 5 to to TO cord-015021-pol2qm74 7567 6 evaluate evaluate VB cord-015021-pol2qm74 7567 7 active active JJ cord-015021-pol2qm74 7567 8 immunization immunization NN cord-015021-pol2qm74 7567 9 as as IN cord-015021-pol2qm74 7567 10 a a DT cord-015021-pol2qm74 7567 11 prophylax prophylax NN cord-015021-pol2qm74 7567 12 ~ ~ NFP cord-015021-pol2qm74 7567 13 s s XX cord-015021-pol2qm74 7567 14 against against IN cord-015021-pol2qm74 7567 15 sepsis sepsis NN cord-015021-pol2qm74 7567 16 . . . cord-015021-pol2qm74 7568 1 Mice mouse NNS cord-015021-pol2qm74 7568 2 were be VBD cord-015021-pol2qm74 7568 3 inoculated inoculate VBN cord-015021-pol2qm74 7568 4 twice twice RB cord-015021-pol2qm74 7568 5 ( ( -LRB- cord-015021-pol2qm74 7568 6 two two CD cord-015021-pol2qm74 7568 7 weeks week NNS cord-015021-pol2qm74 7568 8 apart apart RB cord-015021-pol2qm74 7568 9 ) ) -RRB- cord-015021-pol2qm74 7568 10 with with IN cord-015021-pol2qm74 7568 11 liposomes liposome NNS cord-015021-pol2qm74 7568 12 containing contain VBG cord-015021-pol2qm74 7568 13 DMPC[I.8 DMPC[I.8 NNP cord-015021-pol2qm74 7568 14 ] ] -RRB- cord-015021-pol2qm74 7568 15 , , , cord-015021-pol2qm74 7568 16 DMPG[0.2 DMPG[0.2 NNP cord-015021-pol2qm74 7568 17 ] ] -RRB- cord-015021-pol2qm74 7568 18 , , , cord-015021-pol2qm74 7568 19 cholesterol cholesterol NN cord-015021-pol2qm74 7568 20 [ [ -LRB- cord-015021-pol2qm74 7568 21 1.5 1.5 CD cord-015021-pol2qm74 7568 22 ] ] -RRB- cord-015021-pol2qm74 7568 23 , , , cord-015021-pol2qm74 7568 24 and and CC cord-015021-pol2qm74 7569 1 monophosphoryl monophosphoryl NNP cord-015021-pol2qm74 7569 2 lipid lipid VBG cord-015021-pol2qm74 7569 3 A a DT cord-015021-pol2qm74 7569 4 [ [ -LRB- cord-015021-pol2qm74 7569 5 20 20 CD cord-015021-pol2qm74 7569 6 - - SYM cord-015021-pol2qm74 7569 7 200 200 CD cord-015021-pol2qm74 7569 8 gg gg NNP cord-015021-pol2qm74 7569 9 / / SYM cord-015021-pol2qm74 7569 10 txmole txmole NNP cord-015021-pol2qm74 7569 11 phospholipid phospholipid NN cord-015021-pol2qm74 7569 12 ] ] -RRB- cord-015021-pol2qm74 7569 13 by by IN cord-015021-pol2qm74 7569 14 several several JJ cord-015021-pol2qm74 7569 15 routes route NNS cord-015021-pol2qm74 7569 16 ( ( -LRB- cord-015021-pol2qm74 7569 17 i.p i.p NNP cord-015021-pol2qm74 7569 18 . . NNP cord-015021-pol2qm74 7569 19 , , , cord-015021-pol2qm74 7569 20 i.m i.m NNP cord-015021-pol2qm74 7569 21 . . NNP cord-015021-pol2qm74 7569 22 ) ) -RRB- cord-015021-pol2qm74 7569 23 , , , cord-015021-pol2qm74 7569 24 and and CC cord-015021-pol2qm74 7570 1 serum serum NN cord-015021-pol2qm74 7570 2 was be VBD cord-015021-pol2qm74 7570 3 collected collect VBN cord-015021-pol2qm74 7570 4 10 10 CD cord-015021-pol2qm74 7570 5 - - SYM cord-015021-pol2qm74 7570 6 11 11 CD cord-015021-pol2qm74 7570 7 days day NNS cord-015021-pol2qm74 7570 8 after after IN cord-015021-pol2qm74 7570 9 each each DT cord-015021-pol2qm74 7570 10 inoculation inoculation NN cord-015021-pol2qm74 7570 11 . . . cord-015021-pol2qm74 7571 1 After after IN cord-015021-pol2qm74 7571 2 a a DT cord-015021-pol2qm74 7571 3 single single JJ cord-015021-pol2qm74 7571 4 injection injection NN cord-015021-pol2qm74 7571 5 , , , cord-015021-pol2qm74 7571 6 highest high JJS cord-015021-pol2qm74 7571 7 tilers tiler NNS cord-015021-pol2qm74 7571 8 of of IN cord-015021-pol2qm74 7571 9 Ab Ab NNP cord-015021-pol2qm74 7571 10 were be VBD cord-015021-pol2qm74 7571 11 produced produce VBN cord-015021-pol2qm74 7571 12 in in IN cord-015021-pol2qm74 7571 13 mice mouse NNS cord-015021-pol2qm74 7571 14 inoculated inoculate VBD cord-015021-pol2qm74 7571 15 i.p i.p NNP cord-015021-pol2qm74 7571 16 . . NNP cord-015021-pol2qm74 7571 17 , , , cord-015021-pol2qm74 7571 18 but but CC cord-015021-pol2qm74 7572 1 mice mouse NNS cord-015021-pol2qm74 7572 2 inoculated inoculate VBN cord-015021-pol2qm74 7572 3 by by IN cord-015021-pol2qm74 7572 4 all all DT cord-015021-pol2qm74 7572 5 routes route NNS cord-015021-pol2qm74 7572 6 produced produce VBD cord-015021-pol2qm74 7572 7 anti anti JJ cord-015021-pol2qm74 7572 8 - - JJ cord-015021-pol2qm74 7572 9 lipid lipid JJ cord-015021-pol2qm74 7572 10 A a DT cord-015021-pol2qm74 7572 11 Ab ab NN cord-015021-pol2qm74 7572 12 . . . cord-015021-pol2qm74 7573 1 Following follow VBG cord-015021-pol2qm74 7573 2 the the DT cord-015021-pol2qm74 7573 3 second second JJ cord-015021-pol2qm74 7573 4 injection injection NN cord-015021-pol2qm74 7573 5 . . . cord-015021-pol2qm74 7574 1 Ab Ab NNP cord-015021-pol2qm74 7574 2 levels level NNS cord-015021-pol2qm74 7574 3 were be VBD cord-015021-pol2qm74 7574 4 roughly roughly RB cord-015021-pol2qm74 7574 5 equivalent equivalent JJ cord-015021-pol2qm74 7574 6 in in IN cord-015021-pol2qm74 7574 7 mice mouse NNS cord-015021-pol2qm74 7574 8 inoculated inoculate VBN cord-015021-pol2qm74 7574 9 by by IN cord-015021-pol2qm74 7574 10 all all DT cord-015021-pol2qm74 7574 11 routes route NNS cord-015021-pol2qm74 7574 12 , , , cord-015021-pol2qm74 7574 13 regardless regardless RB cord-015021-pol2qm74 7574 14 of of IN cord-015021-pol2qm74 7574 15 lipid lipid NN cord-015021-pol2qm74 7574 16 A a DT cord-015021-pol2qm74 7574 17 concentration concentration NN cord-015021-pol2qm74 7574 18 . . . cord-015021-pol2qm74 7575 1 Mice mouse NNS cord-015021-pol2qm74 7575 2 vaccinated vaccinate VBD cord-015021-pol2qm74 7575 3 i.p i.p NNP cord-015021-pol2qm74 7575 4 . . . cord-015021-pol2qm74 7576 1 with with IN cord-015021-pol2qm74 7576 2 liposomes liposome NNS cord-015021-pol2qm74 7576 3 containing contain VBG cord-015021-pol2qm74 7576 4 0 0 CD cord-015021-pol2qm74 7576 5 , , , cord-015021-pol2qm74 7576 6 20 20 CD cord-015021-pol2qm74 7576 7 or or CC cord-015021-pol2qm74 7576 8 200 200 CD cord-015021-pol2qm74 7576 9 gg gg NN cord-015021-pol2qm74 7576 10 lipid lipid NN cord-015021-pol2qm74 7576 11 A A NNP cord-015021-pol2qm74 7576 12 were be VBD cord-015021-pol2qm74 7576 13 treated treat VBN cord-015021-pol2qm74 7576 14 with with IN cord-015021-pol2qm74 7576 15 cyclophosphamide cyclophosphamide NN cord-015021-pol2qm74 7576 16 to to TO cord-015021-pol2qm74 7576 17 produce produce VB cord-015021-pol2qm74 7576 18 neutroperda neutroperda NN cord-015021-pol2qm74 7576 19 and and CC cord-015021-pol2qm74 7576 20 then then RB cord-015021-pol2qm74 7576 21 challenged challenge VBD cord-015021-pol2qm74 7576 22 with with IN cord-015021-pol2qm74 7576 23 E. E. NNP cord-015021-pol2qm74 7576 24 cole cole NNP cord-015021-pol2qm74 7576 25 in in IN cord-015021-pol2qm74 7576 26 an an DT cord-015021-pol2qm74 7576 27 infection infection NN cord-015021-pol2qm74 7576 28 model model NN cord-015021-pol2qm74 7576 29 of of IN cord-015021-pol2qm74 7576 30 gram gram NN cord-015021-pol2qm74 7576 31 negative negative JJ cord-015021-pol2qm74 7576 32 sepsis sepsis NN cord-015021-pol2qm74 7576 33 . . . cord-015021-pol2qm74 7577 1 The the DT cord-015021-pol2qm74 7577 2 LDS0 LDS0 NNP cord-015021-pol2qm74 7577 3 for for IN cord-015021-pol2qm74 7577 4 control control NN cord-015021-pol2qm74 7577 5 ( ( -LRB- cord-015021-pol2qm74 7577 6 liposomes liposome NNS cord-015021-pol2qm74 7577 7 with with IN cord-015021-pol2qm74 7577 8 no no DT cord-015021-pol2qm74 7577 9 lipid lipid NN cord-015021-pol2qm74 7577 10 A a NN cord-015021-pol2qm74 7577 11 ) ) -RRB- cord-015021-pol2qm74 7577 12 mice mice NN cord-015021-pol2qm74 7577 13 was be VBD cord-015021-pol2qm74 7577 14 3x10 3x10 CD cord-015021-pol2qm74 7577 15 bacteria bacteria NNS cord-015021-pol2qm74 7577 16 ; ; : cord-015021-pol2qm74 7577 17 LD50 LD50 NNP cord-015021-pol2qm74 7577 18 for for IN cord-015021-pol2qm74 7577 19 mice mouse NNS cord-015021-pol2qm74 7577 20 vaccinated vaccinate VBN cord-015021-pol2qm74 7577 21 with with IN cord-015021-pol2qm74 7577 22 20p.g 20p.g CD cord-015021-pol2qm74 7577 23 was be VBD cord-015021-pol2qm74 7577 24 24x103 24x103 NNS cord-015021-pol2qm74 7578 1 ( ( -LRB- cord-015021-pol2qm74 7578 2 8-fold 8-fold CD cord-015021-pol2qm74 7578 3 increase increase NN cord-015021-pol2qm74 7578 4 in in IN cord-015021-pol2qm74 7578 5 resistance resistance NN cord-015021-pol2qm74 7578 6 ) ) -RRB- cord-015021-pol2qm74 7579 1 and and CC cord-015021-pol2qm74 7579 2 with with IN cord-015021-pol2qm74 7579 3 200~tg 200~tg CD cord-015021-pol2qm74 7579 4 was be VBD cord-015021-pol2qm74 7579 5 48x103 48x103 CD cord-015021-pol2qm74 7579 6 bacteria bacteria NNS cord-015021-pol2qm74 7579 7 ( ( -LRB- cord-015021-pol2qm74 7579 8 16-laid 16-laid CD cord-015021-pol2qm74 7579 9 increase increase NN cord-015021-pol2qm74 7579 10 in in IN cord-015021-pol2qm74 7579 11 resistance resistance NN cord-015021-pol2qm74 7579 12 ) ) -RRB- cord-015021-pol2qm74 7579 13 . . . cord-015021-pol2qm74 7580 1 Mice mouse NNS cord-015021-pol2qm74 7580 2 vaccinated vaccinate VBN cord-015021-pol2qm74 7580 3 as as IN cord-015021-pol2qm74 7580 4 before before RB cord-015021-pol2qm74 7580 5 were be VBD cord-015021-pol2qm74 7580 6 also also RB cord-015021-pol2qm74 7580 7 treated treat VBN cord-015021-pol2qm74 7580 8 with with IN cord-015021-pol2qm74 7580 9 Actinomyein Actinomyein NNP cord-015021-pol2qm74 7580 10 D D NNP cord-015021-pol2qm74 7580 11 to to TO cord-015021-pol2qm74 7580 12 increase increase VB cord-015021-pol2qm74 7580 13 sensitivity sensitivity NN cord-015021-pol2qm74 7580 14 to to IN cord-015021-pol2qm74 7580 15 LPS LPS NNP cord-015021-pol2qm74 7580 16 ( ( -LRB- cord-015021-pol2qm74 7580 17 Salmonella Salmonella NNP cord-015021-pol2qm74 7580 18 minnesota minnesota NNP cord-015021-pol2qm74 7580 19 ) ) -RRB- cord-015021-pol2qm74 7580 20 challenge challenge VBP cord-015021-pol2qm74 7580 21 in in IN cord-015021-pol2qm74 7580 22 an an DT cord-015021-pol2qm74 7580 23 endotoxemia endotoxemia NN cord-015021-pol2qm74 7580 24 model model NN cord-015021-pol2qm74 7580 25 of of IN cord-015021-pol2qm74 7580 26 grain grain NN cord-015021-pol2qm74 7580 27 negative negative JJ cord-015021-pol2qm74 7580 28 sepsis sepsis NN cord-015021-pol2qm74 7580 29 . . . cord-015021-pol2qm74 7581 1 The the DT cord-015021-pol2qm74 7581 2 LD50 LD50 NNP cord-015021-pol2qm74 7581 3 for for IN cord-015021-pol2qm74 7581 4 control control NN cord-015021-pol2qm74 7581 5 ( ( -LRB- cord-015021-pol2qm74 7581 6 liposomes liposome NNS cord-015021-pol2qm74 7581 7 with with IN cord-015021-pol2qm74 7581 8 no no DT cord-015021-pol2qm74 7581 9 lipid lipid NN cord-015021-pol2qm74 7581 10 A a NN cord-015021-pol2qm74 7581 11 ) ) -RRB- cord-015021-pol2qm74 7581 12 mice mice NN cord-015021-pol2qm74 7581 13 was be VBD cord-015021-pol2qm74 7581 14 30 30 CD cord-015021-pol2qm74 7581 15 ng ng NN cord-015021-pol2qm74 7581 16 LPS lp NNS cord-015021-pol2qm74 7581 17 ; ; : cord-015021-pol2qm74 7581 18 the the DT cord-015021-pol2qm74 7581 19 LD50 LD50 NNP cord-015021-pol2qm74 7581 20 for for IN cord-015021-pol2qm74 7582 1 20gg 20gg JJ cord-015021-pol2qm74 7582 2 lipid lipid NN cord-015021-pol2qm74 7582 3 A A NNP cord-015021-pol2qm74 7582 4 was be VBD cord-015021-pol2qm74 7582 5 70rig 70rig JJ cord-015021-pol2qm74 7582 6 LPS lp NNS cord-015021-pol2qm74 7582 7 ( ( -LRB- cord-015021-pol2qm74 7582 8 2-fold 2-fold CD cord-015021-pol2qm74 7582 9 increase increase NN cord-015021-pol2qm74 7582 10 in in IN cord-015021-pol2qm74 7582 11 resistance resistance NN cord-015021-pol2qm74 7582 12 ) ) -RRB- cord-015021-pol2qm74 7582 13 and and CC cord-015021-pol2qm74 7582 14 for for IN cord-015021-pol2qm74 7582 15 2001xg 2001xg NNP cord-015021-pol2qm74 7582 16 was be VBD cord-015021-pol2qm74 7582 17 570ng 570ng JJ cord-015021-pol2qm74 7582 18 LPS LPS NNP cord-015021-pol2qm74 7582 19 ( ( -LRB- cord-015021-pol2qm74 7582 20 19-fold 19-fold CD cord-015021-pol2qm74 7582 21 increase increase NN cord-015021-pol2qm74 7582 22 in in IN cord-015021-pol2qm74 7582 23 resistance resistance NN cord-015021-pol2qm74 7582 24 ) ) -RRB- cord-015021-pol2qm74 7582 25 . . . cord-015021-pol2qm74 7583 1 Mice mouse NNS cord-015021-pol2qm74 7583 2 were be VBD cord-015021-pol2qm74 7583 3 similarly similarly RB cord-015021-pol2qm74 7583 4 vaccinated vaccinate VBN cord-015021-pol2qm74 7583 5 and and CC cord-015021-pol2qm74 7583 6 challenged challenge VBN cord-015021-pol2qm74 7583 7 with with IN cord-015021-pol2qm74 7583 8 an an DT cord-015021-pol2qm74 7583 9 aggressive aggressive JJ cord-015021-pol2qm74 7583 10 gram gram NN cord-015021-pol2qm74 7583 11 negative negative JJ cord-015021-pol2qm74 7583 12 pathogen pathogen NN cord-015021-pol2qm74 7583 13 , , , cord-015021-pol2qm74 7583 14 Francfsella Francfsella NNP cord-015021-pol2qm74 7583 15 tularensis tularensis NNP cord-015021-pol2qm74 7583 16 . . . cord-015021-pol2qm74 7584 1 The the DT cord-015021-pol2qm74 7584 2 LD50 LD50 NNP cord-015021-pol2qm74 7584 3 of of IN cord-015021-pol2qm74 7584 4 FranciseUa FranciseUa NNP cord-015021-pol2qm74 7584 5 in in IN cord-015021-pol2qm74 7584 6 normal normal JJ cord-015021-pol2qm74 7584 7 mice mouse NNS cord-015021-pol2qm74 7584 8 or or CC cord-015021-pol2qm74 7584 9 mice mouse NNS cord-015021-pol2qm74 7584 10 inoculated inoculate VBN cord-015021-pol2qm74 7584 11 with with IN cord-015021-pol2qm74 7584 12 liposomes liposome NNS cord-015021-pol2qm74 7584 13 without without IN cord-015021-pol2qm74 7584 14 lipid lipid NN cord-015021-pol2qm74 7584 15 A A NNP cord-015021-pol2qm74 7584 16 was be VBD cord-015021-pol2qm74 7584 17 20 20 CD cord-015021-pol2qm74 7584 18 - - SYM cord-015021-pol2qm74 7584 19 40 40 CD cord-015021-pol2qm74 7584 20 bacteria bacteria NNS cord-015021-pol2qm74 7584 21 . . . cord-015021-pol2qm74 7585 1 In in IN cord-015021-pol2qm74 7585 2 contrast contrast NN cord-015021-pol2qm74 7585 3 , , , cord-015021-pol2qm74 7585 4 mice mouse NNS cord-015021-pol2qm74 7585 5 vaccinated vaccinate VBN cord-015021-pol2qm74 7585 6 with with IN cord-015021-pol2qm74 7585 7 liposomal liposomal JJ cord-015021-pol2qm74 7585 8 lipid lipid NN cord-015021-pol2qm74 7585 9 A a NN cord-015021-pol2qm74 7585 10 ( ( -LRB- cord-015021-pol2qm74 7586 1 200ggl 200ggl CD cord-015021-pol2qm74 7586 2 survived survive VBD cord-015021-pol2qm74 7586 3 challenges challenge NNS cord-015021-pol2qm74 7586 4 as as RB cord-015021-pol2qm74 7586 5 high high JJ cord-015021-pol2qm74 7586 6 as as IN cord-015021-pol2qm74 7586 7 30,000 30,000 CD cord-015021-pol2qm74 7586 8 bacteria bacteria NNS cord-015021-pol2qm74 7586 9 , , , cord-015021-pol2qm74 7586 10 ( ( -LRB- cord-015021-pol2qm74 7586 11 3 3 CD cord-015021-pol2qm74 7586 12 logs log NNS cord-015021-pol2qm74 7586 13 of of IN cord-015021-pol2qm74 7586 14 protection protection NN cord-015021-pol2qm74 7586 15 ) ) -RRB- cord-015021-pol2qm74 7586 16 . . . cord-015021-pol2qm74 7587 1 The the DT cord-015021-pol2qm74 7587 2 impressive impressive JJ cord-015021-pol2qm74 7587 3 protective protective JJ cord-015021-pol2qm74 7587 4 capacity capacity NN cord-015021-pol2qm74 7587 5 of of IN cord-015021-pol2qm74 7587 6 this this DT cord-015021-pol2qm74 7587 7 vaccine vaccine NN cord-015021-pol2qm74 7587 8 did do VBD cord-015021-pol2qm74 7587 9 not not RB cord-015021-pol2qm74 7587 10 correlate correlate VB cord-015021-pol2qm74 7587 11 with with IN cord-015021-pol2qm74 7587 12 Ab Ab NNP cord-015021-pol2qm74 7587 13 Liter Liter NNP cord-015021-pol2qm74 7587 14 in in IN cord-015021-pol2qm74 7587 15 any any DT cord-015021-pol2qm74 7587 16 of of IN cord-015021-pol2qm74 7587 17 the the DT cord-015021-pol2qm74 7587 18 sepsis sepsis NN cord-015021-pol2qm74 7587 19 models model NNS cord-015021-pol2qm74 7587 20 , , , cord-015021-pol2qm74 7587 21 nor nor CC cord-015021-pol2qm74 7587 22 did do VBD cord-015021-pol2qm74 7587 23 it -PRON- PRP cord-015021-pol2qm74 7587 24 correlate correlate VB cord-015021-pol2qm74 7587 25 with with IN cord-015021-pol2qm74 7587 26 classic classic JJ cord-015021-pol2qm74 7587 27 nonspeeific nonspeeific JJ cord-015021-pol2qm74 7587 28 events event NNS cord-015021-pol2qm74 7587 29 , , , cord-015021-pol2qm74 7587 30 such such JJ cord-015021-pol2qm74 7587 31 as as IN cord-015021-pol2qm74 7587 32 macrophage macrophage NN cord-015021-pol2qm74 7587 33 activation activation NN cord-015021-pol2qm74 7587 34 . . . cord-015021-pol2qm74 7588 1 Maerophages maerophage NNS cord-015021-pol2qm74 7588 2 harvested harvest VBN cord-015021-pol2qm74 7588 3 from from IN cord-015021-pol2qm74 7588 4 the the DT cord-015021-pol2qm74 7588 5 peritoneum peritoneum NN cord-015021-pol2qm74 7588 6 of of IN cord-015021-pol2qm74 7588 7 mice mouse NNS cord-015021-pol2qm74 7588 8 vaccinated vaccinate VBN cord-015021-pol2qm74 7588 9 and and CC cord-015021-pol2qm74 7588 10 protected protect VBN cord-015021-pol2qm74 7588 11 against against IN cord-015021-pol2qm74 7588 12 sequelae sequela NNS cord-015021-pol2qm74 7588 13 of of IN cord-015021-pol2qm74 7588 14 gram gram NN cord-015021-pol2qm74 7588 15 negative negative JJ cord-015021-pol2qm74 7588 16 infections infection NNS cord-015021-pol2qm74 7588 17 did do VBD cord-015021-pol2qm74 7588 18 not not RB cord-015021-pol2qm74 7588 19 spontaneously spontaneously RB cord-015021-pol2qm74 7588 20 kill kill VB cord-015021-pol2qm74 7588 21 the the DT cord-015021-pol2qm74 7588 22 bacteria bacteria NNS cord-015021-pol2qm74 7588 23 in in IN cord-015021-pol2qm74 7588 24 vitro vitro FW cord-015021-pol2qm74 7588 25 , , , cord-015021-pol2qm74 7588 26 but but CC cord-015021-pol2qm74 7588 27 could could MD cord-015021-pol2qm74 7588 28 be be VB cord-015021-pol2qm74 7588 29 activated activate VBN cord-015021-pol2qm74 7588 30 by by IN cord-015021-pol2qm74 7588 31 IFN IFN NNP cord-015021-pol2qm74 7588 32 - - HYPH cord-015021-pol2qm74 7588 33 y y NNP cord-015021-pol2qm74 7588 34 for for IN cord-015021-pol2qm74 7588 35 antimicrobial antimicrobial JJ cord-015021-pol2qm74 7588 36 activity activity NN cord-015021-pol2qm74 7588 37 equivalent equivalent JJ cord-015021-pol2qm74 7588 38 to to IN cord-015021-pol2qm74 7588 39 that that DT cord-015021-pol2qm74 7588 40 of of IN cord-015021-pol2qm74 7588 41 macrophages macrophage NNS cord-015021-pol2qm74 7588 42 from from IN cord-015021-pol2qm74 7588 43 unt#eated unt#eated NNP cord-015021-pol2qm74 7588 44 mice mouse NNS cord-015021-pol2qm74 7588 45 . . . cord-015021-pol2qm74 7589 1 Research research NN cord-015021-pol2qm74 7589 2 is be VBZ cord-015021-pol2qm74 7589 3 underway underway JJ cord-015021-pol2qm74 7589 4 to to TO cord-015021-pol2qm74 7589 5 defme defme VB cord-015021-pol2qm74 7589 6 the the DT cord-015021-pol2qm74 7589 7 protective protective JJ cord-015021-pol2qm74 7589 8 mechanism(s mechanism(s NN cord-015021-pol2qm74 7589 9 ) ) -RRB- cord-015021-pol2qm74 7590 1 activated activate VBN cord-015021-pol2qm74 7590 2 by by IN cord-015021-pol2qm74 7590 3 this this DT cord-015021-pol2qm74 7590 4 liposomal liposomal NN cord-015021-pol2qm74 7590 5 - - HYPH cord-015021-pol2qm74 7590 6 Lipid lipid NN cord-015021-pol2qm74 7590 7 A a DT cord-015021-pol2qm74 7590 8 vaccine vaccine NN cord-015021-pol2qm74 7590 9 . . . cord-015021-pol2qm74 7591 1 INTERVENTION intervention NN cord-015021-pol2qm74 7591 2 BY by IN cord-015021-pol2qm74 7591 3 MONOPHOSPHORYL MONOPHOSPHORYL NNP cord-015021-pol2qm74 7591 4 LIPID LIPID NNP cord-015021-pol2qm74 7591 5 A a DT cord-015021-pol2qm74 7592 1 IN in IN cord-015021-pol2qm74 7592 2 SEPTIC septic JJ cord-015021-pol2qm74 7592 3 SHOCK shock NN cord-015021-pol2qm74 7593 1 Jon Jon NNP cord-015021-pol2qm74 7593 2 A. A. NNP cord-015021-pol2qm74 7593 3 Rudbach Rudbach NNP cord-015021-pol2qm74 7593 4 , , , cord-015021-pol2qm74 7593 5 Ribi Ribi NNP cord-015021-pol2qm74 7593 6 ImmunoChem ImmunoChem NNP cord-015021-pol2qm74 7593 7 Research Research NNP cord-015021-pol2qm74 7593 8 , , , cord-015021-pol2qm74 7593 9 Inc. Inc. NNP cord-015021-pol2qm74 7593 10 , , , cord-015021-pol2qm74 7593 11 Hamilton Hamilton NNP cord-015021-pol2qm74 7593 12 , , , cord-015021-pol2qm74 7593 13 Montana Montana NNP cord-015021-pol2qm74 7593 14 , , , cord-015021-pol2qm74 7593 15 USA USA NNP cord-015021-pol2qm74 7593 16 Monophosphoryl Monophosphoryl NNP cord-015021-pol2qm74 7593 17 Lipid Lipid NNP cord-015021-pol2qm74 7593 18 A A NNP cord-015021-pol2qm74 7593 19 ( ( -LRB- cord-015021-pol2qm74 7593 20 MLA MLA NNP cord-015021-pol2qm74 7593 21 ) ) -RRB- cord-015021-pol2qm74 7593 22 , , , cord-015021-pol2qm74 7593 23 the the DT cord-015021-pol2qm74 7593 24 clinical clinical JJ cord-015021-pol2qm74 7593 25 form form NN cord-015021-pol2qm74 7593 26 of of IN cord-015021-pol2qm74 7593 27 which which WDT cord-015021-pol2qm74 7593 28 is be VBZ cord-015021-pol2qm74 7593 29 called call VBN cord-015021-pol2qm74 7593 30 MPL MPL NNP cord-015021-pol2qm74 7593 31 ® ® NNP cord-015021-pol2qm74 7593 32 -immunostimulant -immunostimulant CD cord-015021-pol2qm74 7593 33 , , , cord-015021-pol2qm74 7593 34 has have VBZ cord-015021-pol2qm74 7593 35 been be VBN cord-015021-pol2qm74 7593 36 tested test VBN cord-015021-pol2qm74 7593 37 extensively extensively RB cord-015021-pol2qm74 7593 38 as as IN cord-015021-pol2qm74 7593 39 an an DT cord-015021-pol2qm74 7593 40 intervenient intervenient NN cord-015021-pol2qm74 7593 41 material material NN cord-015021-pol2qm74 7593 42 in in IN cord-015021-pol2qm74 7593 43 septic septic JJ cord-015021-pol2qm74 7593 44 shock shock NN cord-015021-pol2qm74 7593 45 . . . cord-015021-pol2qm74 7594 1 MLA MLA NNP cord-015021-pol2qm74 7594 2 is be VBZ cord-015021-pol2qm74 7594 3 protective protective JJ cord-015021-pol2qm74 7594 4 when when WRB cord-015021-pol2qm74 7594 5 given give VBN cord-015021-pol2qm74 7594 6 to to IN cord-015021-pol2qm74 7594 7 experimental experimental JJ cord-015021-pol2qm74 7594 8 animals animal NNS cord-015021-pol2qm74 7594 9 prior prior RB cord-015021-pol2qm74 7594 10 to to IN cord-015021-pol2qm74 7594 11 a a DT cord-015021-pol2qm74 7594 12 live live JJ cord-015021-pol2qm74 7594 13 microbial microbial JJ cord-015021-pol2qm74 7594 14 challenge challenge NN cord-015021-pol2qm74 7594 15 or or CC cord-015021-pol2qm74 7594 16 challenge challenge NN cord-015021-pol2qm74 7594 17 with with IN cord-015021-pol2qm74 7594 18 lethal lethal JJ cord-015021-pol2qm74 7594 19 doses dose NNS cord-015021-pol2qm74 7594 20 of of IN cord-015021-pol2qm74 7594 21 microbial microbial JJ cord-015021-pol2qm74 7594 22 products product NNS cord-015021-pol2qm74 7594 23 or or CC cord-015021-pol2qm74 7594 24 certain certain JJ cord-015021-pol2qm74 7594 25 cytokines cytokine NNS cord-015021-pol2qm74 7594 26 . . . cord-015021-pol2qm74 7595 1 This this DT cord-015021-pol2qm74 7595 2 is be VBZ cord-015021-pol2qm74 7595 3 shown show VBN cord-015021-pol2qm74 7595 4 with with IN cord-015021-pol2qm74 7595 5 Gram Gram NNP cord-015021-pol2qm74 7595 6 negative negative JJ cord-015021-pol2qm74 7595 7 and and CC cord-015021-pol2qm74 7595 8 Gram Gram NNP cord-015021-pol2qm74 7595 9 positive positive JJ cord-015021-pol2qm74 7595 10 bacteria bacteria NNS cord-015021-pol2qm74 7595 11 , , , cord-015021-pol2qm74 7595 12 Gram Gram NNP cord-015021-pol2qm74 7595 13 negative negative JJ cord-015021-pol2qm74 7595 14 bacterial bacterial JJ cord-015021-pol2qm74 7595 15 endotoxins endotoxin NNS cord-015021-pol2qm74 7595 16 , , , cord-015021-pol2qm74 7595 17 and and CC cord-015021-pol2qm74 7595 18 Gram Gram NNP cord-015021-pol2qm74 7595 19 positive positive JJ cord-015021-pol2qm74 7595 20 bacterial bacterial JJ cord-015021-pol2qm74 7595 21 exotoxins exotoxin NNS cord-015021-pol2qm74 7595 22 . . . cord-015021-pol2qm74 7596 1 Furthermore furthermore RB cord-015021-pol2qm74 7596 2 , , , cord-015021-pol2qm74 7596 3 animals animal NNS cord-015021-pol2qm74 7596 4 treated treat VBN cord-015021-pol2qm74 7596 5 with with IN cord-015021-pol2qm74 7596 6 a a DT cord-015021-pol2qm74 7596 7 regimen regimen NN cord-015021-pol2qm74 7596 8 of of IN cord-015021-pol2qm74 7596 9 MLA MLA NNP cord-015021-pol2qm74 7596 10 which which WDT cord-015021-pol2qm74 7596 11 results result VBZ cord-015021-pol2qm74 7596 12 in in IN cord-015021-pol2qm74 7596 13 a a DT cord-015021-pol2qm74 7596 14 refractory refractory JJ cord-015021-pol2qm74 7596 15 state state NN cord-015021-pol2qm74 7596 16 to to IN cord-015021-pol2qm74 7596 17 a a DT cord-015021-pol2qm74 7596 18 lethal lethal JJ cord-015021-pol2qm74 7596 19 dose dose NN cord-015021-pol2qm74 7596 20 of of IN cord-015021-pol2qm74 7596 21 Gram Gram NNP cord-015021-pol2qm74 7596 22 negative negative JJ cord-015021-pol2qm74 7596 23 bacterial bacterial JJ cord-015021-pol2qm74 7596 24 endotoxin endotoxin NN cord-015021-pol2qm74 7596 25 concomitantly concomitantly RB cord-015021-pol2qm74 7596 26 display display NN cord-015021-pol2qm74 7596 27 increased increase VBN cord-015021-pol2qm74 7596 28 resistance resistance NN cord-015021-pol2qm74 7596 29 to to IN cord-015021-pol2qm74 7596 30 a a DT cord-015021-pol2qm74 7596 31 live live JJ cord-015021-pol2qm74 7596 32 bacterial bacterial JJ cord-015021-pol2qm74 7596 33 challenge challenge NN cord-015021-pol2qm74 7596 34 . . . cord-015021-pol2qm74 7597 1 Thus thus RB cord-015021-pol2qm74 7597 2 , , , cord-015021-pol2qm74 7597 3 both both DT cord-015021-pol2qm74 7597 4 endotoxin endotoxin NN cord-015021-pol2qm74 7597 5 tolerance tolerance NN cord-015021-pol2qm74 7597 6 and and CC cord-015021-pol2qm74 7597 7 nonspeciflc nonspeciflc NN cord-015021-pol2qm74 7597 8 resistance resistance NN cord-015021-pol2qm74 7597 9 to to IN cord-015021-pol2qm74 7597 10 infection infection NN cord-015021-pol2qm74 7597 11 can can MD cord-015021-pol2qm74 7597 12 be be VB cord-015021-pol2qm74 7597 13 manifested manifest VBN cord-015021-pol2qm74 7597 14 simultaneously simultaneously RB cord-015021-pol2qm74 7597 15 . . . cord-015021-pol2qm74 7598 1 Also also RB cord-015021-pol2qm74 7598 2 , , , cord-015021-pol2qm74 7598 3 prophylactic prophylactic JJ cord-015021-pol2qm74 7598 4 doses dose NNS cord-015021-pol2qm74 7598 5 of of IN cord-015021-pol2qm74 7598 6 MLA MLA NNP cord-015021-pol2qm74 7598 7 do do VBP cord-015021-pol2qm74 7598 8 not not RB cord-015021-pol2qm74 7598 9 interfere interfere VB cord-015021-pol2qm74 7598 10 with with IN cord-015021-pol2qm74 7598 11 other other JJ cord-015021-pol2qm74 7598 12 therapies therapy NNS cord-015021-pol2qm74 7598 13 given give VBN cord-015021-pol2qm74 7598 14 subsequently subsequently RB cord-015021-pol2qm74 7598 15 ; ; : cord-015021-pol2qm74 7598 16 an an DT cord-015021-pol2qm74 7598 17 additive additive NN cord-015021-pol2qm74 7598 18 or or CC cord-015021-pol2qm74 7598 19 a a DT cord-015021-pol2qm74 7598 20 synergistic synergistic JJ cord-015021-pol2qm74 7598 21 protective protective JJ cord-015021-pol2qm74 7598 22 effect effect NN cord-015021-pol2qm74 7598 23 can can MD cord-015021-pol2qm74 7598 24 be be VB cord-015021-pol2qm74 7598 25 demonstrated demonstrate VBN cord-015021-pol2qm74 7598 26 with with IN cord-015021-pol2qm74 7598 27 certain certain JJ cord-015021-pol2qm74 7598 28 combinatorial combinatorial JJ cord-015021-pol2qm74 7598 29 treatment treatment NN cord-015021-pol2qm74 7598 30 regimens regimen NNS cord-015021-pol2qm74 7598 31 , , , cord-015021-pol2qm74 7598 32 such such JJ cord-015021-pol2qm74 7598 33 as as IN cord-015021-pol2qm74 7598 34 MLA MLA NNP cord-015021-pol2qm74 7598 35 followed follow VBD cord-015021-pol2qm74 7598 36 by by IN cord-015021-pol2qm74 7598 37 antiendotoxin antiendotoxin NNP cord-015021-pol2qm74 7598 38 monoclonal monoclonal JJ cord-015021-pol2qm74 7598 39 antibodies antibody NNS cord-015021-pol2qm74 7598 40 . . . cord-015021-pol2qm74 7599 1 The the DT cord-015021-pol2qm74 7599 2 preclinical preclinical JJ cord-015021-pol2qm74 7599 3 studies study NNS cord-015021-pol2qm74 7599 4 were be VBD cord-015021-pol2qm74 7599 5 extended extend VBN cord-015021-pol2qm74 7599 6 to to IN cord-015021-pol2qm74 7599 7 human human JJ cord-015021-pol2qm74 7599 8 trials trial NNS cord-015021-pol2qm74 7599 9 wherein wherein WRB cord-015021-pol2qm74 7599 10 the the DT cord-015021-pol2qm74 7599 11 safety safety NN cord-015021-pol2qm74 7599 12 of of IN cord-015021-pol2qm74 7599 13 agonistic agonistic JJ cord-015021-pol2qm74 7599 14 doses dose NNS cord-015021-pol2qm74 7599 15 of of IN cord-015021-pol2qm74 7599 16 MLA MLA NNP cord-015021-pol2qm74 7599 17 was be VBD cord-015021-pol2qm74 7599 18 verified verify VBN cord-015021-pol2qm74 7599 19 . . . cord-015021-pol2qm74 7600 1 Furthermore furthermore RB cord-015021-pol2qm74 7600 2 , , , cord-015021-pol2qm74 7600 3 when when WRB cord-015021-pol2qm74 7600 4 MLA MLA NNP cord-015021-pol2qm74 7600 5 was be VBD cord-015021-pol2qm74 7600 6 administered administer VBN cord-015021-pol2qm74 7600 7 to to IN cord-015021-pol2qm74 7600 8 human human JJ cord-015021-pol2qm74 7600 9 volunteers volunteer NNS cord-015021-pol2qm74 7600 10 24 24 CD cord-015021-pol2qm74 7600 11 hr hr NN cord-015021-pol2qm74 7600 12 before before IN cord-015021-pol2qm74 7600 13 challenge challenge NN cord-015021-pol2qm74 7600 14 with with IN cord-015021-pol2qm74 7600 15 a a DT cord-015021-pol2qm74 7600 16 pharmacologically pharmacologically RB cord-015021-pol2qm74 7600 17 active active JJ cord-015021-pol2qm74 7600 18 dose dose NN cord-015021-pol2qm74 7600 19 of of IN cord-015021-pol2qm74 7600 20 reference reference NN cord-015021-pol2qm74 7600 21 endotoxin endotoxin NN cord-015021-pol2qm74 7600 22 , , , cord-015021-pol2qm74 7600 23 febrile febrile JJ cord-015021-pol2qm74 7600 24 , , , cord-015021-pol2qm74 7600 25 cardiac cardiac NN cord-015021-pol2qm74 7600 26 , , , cord-015021-pol2qm74 7600 27 TNF TNF NNP cord-015021-pol2qm74 7600 28 , , , cord-015021-pol2qm74 7600 29 IL-6 IL-6 NNP cord-015021-pol2qm74 7600 30 , , , cord-015021-pol2qm74 7600 31 and and CC cord-015021-pol2qm74 7600 32 IL-8 il-8 NN cord-015021-pol2qm74 7600 33 responses response NNS cord-015021-pol2qm74 7600 34 were be VBD cord-015021-pol2qm74 7600 35 all all DT cord-015021-pol2qm74 7600 36 decreased decrease VBN cord-015021-pol2qm74 7600 37 significantly significantly RB cord-015021-pol2qm74 7600 38 as as IN cord-015021-pol2qm74 7600 39 compared compare VBN cord-015021-pol2qm74 7600 40 with with IN cord-015021-pol2qm74 7600 41 the the DT cord-015021-pol2qm74 7600 42 responses response NNS cord-015021-pol2qm74 7600 43 of of IN cord-015021-pol2qm74 7600 44 subjects subject NNS cord-015021-pol2qm74 7600 45 pretreated pretreate VBN cord-015021-pol2qm74 7600 46 with with IN cord-015021-pol2qm74 7600 47 a a DT cord-015021-pol2qm74 7600 48 control control NN cord-015021-pol2qm74 7600 49 solution solution NN cord-015021-pol2qm74 7600 50 and and CC cord-015021-pol2qm74 7600 51 challenged challenge VBN cord-015021-pol2qm74 7600 52 with with IN cord-015021-pol2qm74 7600 53 endotoxin endotoxin NN cord-015021-pol2qm74 7600 54 . . . cord-015021-pol2qm74 7601 1 Human human JJ cord-015021-pol2qm74 7601 2 trials trial NNS cord-015021-pol2qm74 7601 3 with with IN cord-015021-pol2qm74 7601 4 MLA MLA NNP cord-015021-pol2qm74 7601 5 are be VBP cord-015021-pol2qm74 7601 6 being be VBG cord-015021-pol2qm74 7601 7 extended extend VBN cord-015021-pol2qm74 7601 8 into into IN cord-015021-pol2qm74 7601 9 patient patient JJ cord-015021-pol2qm74 7601 10 cohorts cohort NNS cord-015021-pol2qm74 7601 11 which which WDT cord-015021-pol2qm74 7601 12 have have VBP cord-015021-pol2qm74 7601 13 high high JJ cord-015021-pol2qm74 7601 14 probabilities probability NNS cord-015021-pol2qm74 7601 15 of of IN cord-015021-pol2qm74 7601 16 developing develop VBG cord-015021-pol2qm74 7601 17 septic septic JJ cord-015021-pol2qm74 7601 18 shock shock NN cord-015021-pol2qm74 7601 19 ; ; : cord-015021-pol2qm74 7601 20 this this DT cord-015021-pol2qm74 7601 21 will will MD cord-015021-pol2qm74 7601 22 expand expand VB cord-015021-pol2qm74 7601 23 the the DT cord-015021-pol2qm74 7601 24 safety safety NN cord-015021-pol2qm74 7601 25 base base NN cord-015021-pol2qm74 7601 26 and and CC cord-015021-pol2qm74 7601 27 establish establish VB cord-015021-pol2qm74 7601 28 clinical clinical JJ cord-015021-pol2qm74 7601 29 efficacy efficacy NN cord-015021-pol2qm74 7601 30 for for IN cord-015021-pol2qm74 7601 31 MPL MPL NNP cord-015021-pol2qm74 7601 32 ® ® POS cord-015021-pol2qm74 7601 33 -immunostimulant -immunostimulant CD cord-015021-pol2qm74 7601 34 . . . cord-015021-pol2qm74 7602 1 A a DT cord-015021-pol2qm74 7602 2 considerable considerable JJ cord-015021-pol2qm74 7602 3 body body NN cord-015021-pol2qm74 7602 4 of of IN cord-015021-pol2qm74 7602 5 in in FW cord-015021-pol2qm74 7602 6 vitro vitro FW cord-015021-pol2qm74 7602 7 evidence evidence NN cord-015021-pol2qm74 7602 8 supports support VBZ cord-015021-pol2qm74 7602 9 the the DT cord-015021-pol2qm74 7602 10 concept concept NN cord-015021-pol2qm74 7602 11 that that IN cord-015021-pol2qm74 7602 12 the the DT cord-015021-pol2qm74 7602 13 effects effect NNS cord-015021-pol2qm74 7602 14 of of IN cord-015021-pol2qm74 7602 15 LPS lp NNS cord-015021-pol2qm74 7602 16 on on IN cord-015021-pol2qm74 7602 17 cells cell NNS cord-015021-pol2qm74 7602 18 of of IN cord-015021-pol2qm74 7602 19 the the DT cord-015021-pol2qm74 7602 20 immune immune JJ cord-015021-pol2qm74 7602 21 / / SYM cord-015021-pol2qm74 7602 22 inflammatory inflammatory JJ cord-015021-pol2qm74 7602 23 systems system NNS cord-015021-pol2qm74 7602 24 are be VBP cord-015021-pol2qm74 7602 25 controlled control VBN cord-015021-pol2qm74 7602 26 by by IN cord-015021-pol2qm74 7602 27 interactions interaction NNS cord-015021-pol2qm74 7602 28 of of IN cord-015021-pol2qm74 7602 29 LPS LPS NNP cord-015021-pol2qm74 7602 30 with with IN cord-015021-pol2qm74 7602 31 CD14 CD14 NNP cord-015021-pol2qm74 7602 32 . . . cord-015021-pol2qm74 7603 1 To to TO cord-015021-pol2qm74 7603 2 evaluate evaluate VB cord-015021-pol2qm74 7603 3 if if IN cord-015021-pol2qm74 7603 4 blocking block VBG cord-015021-pol2qm74 7603 5 LPS LPS NNP cord-015021-pol2qm74 7603 6 - - HYPH cord-015021-pol2qm74 7603 7 CD14 CD14 NNP cord-015021-pol2qm74 7603 8 interactions interaction NNS cord-015021-pol2qm74 7603 9 has have VBZ cord-015021-pol2qm74 7603 10 potential potential JJ cord-015021-pol2qm74 7603 11 as as IN cord-015021-pol2qm74 7603 12 a a DT cord-015021-pol2qm74 7603 13 therapeutic therapeutic JJ cord-015021-pol2qm74 7603 14 in in IN cord-015021-pol2qm74 7603 15 septic septic JJ cord-015021-pol2qm74 7603 16 shock shock NN cord-015021-pol2qm74 7603 17 we -PRON- PRP cord-015021-pol2qm74 7603 18 have have VBP cord-015021-pol2qm74 7603 19 evaluated evaluate VBN cord-015021-pol2qm74 7603 20 the the DT cord-015021-pol2qm74 7603 21 effect effect NN cord-015021-pol2qm74 7603 22 of of IN cord-015021-pol2qm74 7603 23 anti anti JJ cord-015021-pol2qm74 7603 24 - - JJ cord-015021-pol2qm74 7603 25 CDI4 cdi4 JJ cord-015021-pol2qm74 7603 26 monoclonal monoclonal JJ cord-015021-pol2qm74 7603 27 antibody antibody NN cord-015021-pol2qm74 7603 28 ( ( -LRB- cord-015021-pol2qm74 7603 29 mAb mAb NNS cord-015021-pol2qm74 7603 30 ) ) -RRB- cord-015021-pol2qm74 7603 31 on on IN cord-015021-pol2qm74 7603 32 LPS LPS NNP cord-015021-pol2qm74 7603 33 - - HYPH cord-015021-pol2qm74 7603 34 induced induce VBN cord-015021-pol2qm74 7603 35 cytokine cytokine NN cord-015021-pol2qm74 7603 36 production production NN cord-015021-pol2qm74 7603 37 and and CC cord-015021-pol2qm74 7603 38 physiologic physiologic JJ cord-015021-pol2qm74 7603 39 changes change NNS cord-015021-pol2qm74 7603 40 in in IN cord-015021-pol2qm74 7603 41 an an DT cord-015021-pol2qm74 7603 42 experimental experimental JJ cord-015021-pol2qm74 7603 43 model model NN cord-015021-pol2qm74 7603 44 of of IN cord-015021-pol2qm74 7603 45 endotoxin endotoxin NN cord-015021-pol2qm74 7603 46 shock shock NN cord-015021-pol2qm74 7603 47 performed perform VBN cord-015021-pol2qm74 7603 48 in in IN cord-015021-pol2qm74 7603 49 cynomolgus cynomolgus JJ cord-015021-pol2qm74 7603 50 monkeys monkey NNS cord-015021-pol2qm74 7603 51 . . . cord-015021-pol2qm74 7604 1 A a DT cord-015021-pol2qm74 7604 2 novel novel JJ cord-015021-pol2qm74 7604 3 model model NN cord-015021-pol2qm74 7604 4 has have VBZ cord-015021-pol2qm74 7604 5 been be VBN cord-015021-pol2qm74 7604 6 established establish VBN cord-015021-pol2qm74 7604 7 where where WRB cord-015021-pol2qm74 7604 8 animals animal NNS cord-015021-pol2qm74 7604 9 were be VBD cord-015021-pol2qm74 7604 10 treated treat VBN cord-015021-pol2qm74 7604 11 with with IN cord-015021-pol2qm74 7604 12 interferongamma interferongamma NNP cord-015021-pol2qm74 7604 13 for for IN cord-015021-pol2qm74 7604 14 three three CD cord-015021-pol2qm74 7604 15 days day NNS cord-015021-pol2qm74 7604 16 prior prior RB cord-015021-pol2qm74 7604 17 to to IN cord-015021-pol2qm74 7604 18 infusion infusion NN cord-015021-pol2qm74 7604 19 of of IN cord-015021-pol2qm74 7604 20 highly highly RB cord-015021-pol2qm74 7604 21 purified purify VBN cord-015021-pol2qm74 7604 22 LPS lp NNS cord-015021-pol2qm74 7604 23 over over RP cord-015021-pol2qm74 7604 24 an an DT cord-015021-pol2qm74 7604 25 eight eight CD cord-015021-pol2qm74 7604 26 hour hour NN cord-015021-pol2qm74 7604 27 period period NN cord-015021-pol2qm74 7604 28 . . . cord-015021-pol2qm74 7605 1 In in IN cord-015021-pol2qm74 7605 2 this this DT cord-015021-pol2qm74 7605 3 model model NN cord-015021-pol2qm74 7605 4 LPS LPS NNP cord-015021-pol2qm74 7605 5 challenge challenge NN cord-015021-pol2qm74 7605 6 resulted result VBD cord-015021-pol2qm74 7605 7 in in IN cord-015021-pol2qm74 7605 8 marked marked JJ cord-015021-pol2qm74 7605 9 release release NN cord-015021-pol2qm74 7605 10 of of IN cord-015021-pol2qm74 7605 11 eytokines eytokine NNS cord-015021-pol2qm74 7605 12 in in IN cord-015021-pol2qm74 7605 13 the the DT cord-015021-pol2qm74 7605 14 blood blood NN cord-015021-pol2qm74 7605 15 , , , cord-015021-pol2qm74 7605 16 substantial substantial JJ cord-015021-pol2qm74 7605 17 hemodynamic hemodynamic JJ cord-015021-pol2qm74 7605 18 changes change NNS cord-015021-pol2qm74 7605 19 , , , cord-015021-pol2qm74 7605 20 release release NN cord-015021-pol2qm74 7605 21 of of IN cord-015021-pol2qm74 7605 22 liver liver NN cord-015021-pol2qm74 7605 23 enzymes enzyme NNS cord-015021-pol2qm74 7605 24 and and CC cord-015021-pol2qm74 7605 25 alteration alteration NN cord-015021-pol2qm74 7605 26 in in IN cord-015021-pol2qm74 7605 27 lung lung NN cord-015021-pol2qm74 7605 28 permeability permeability NN cord-015021-pol2qm74 7605 29 observed observe VBD cord-015021-pol2qm74 7605 30 over over IN cord-015021-pol2qm74 7605 31 a a DT cord-015021-pol2qm74 7605 32 24 24 CD cord-015021-pol2qm74 7605 33 hour hour NN cord-015021-pol2qm74 7605 34 period period NN cord-015021-pol2qm74 7605 35 . . . cord-015021-pol2qm74 7606 1 To to TO cord-015021-pol2qm74 7606 2 evaluate evaluate VB cord-015021-pol2qm74 7606 3 the the DT cord-015021-pol2qm74 7606 4 effect effect NN cord-015021-pol2qm74 7606 5 of of IN cord-015021-pol2qm74 7606 6 treatment treatment NN cord-015021-pol2qm74 7606 7 with with IN cord-015021-pol2qm74 7606 8 anti anti JJ cord-015021-pol2qm74 7606 9 - - JJ cord-015021-pol2qm74 7606 10 CD14 cd14 JJ cord-015021-pol2qm74 7606 11 mAb mAb NNS cord-015021-pol2qm74 7606 12 , , , cord-015021-pol2qm74 7606 13 animals animal NNS cord-015021-pol2qm74 7606 14 were be VBD cord-015021-pol2qm74 7606 15 given give VBN cord-015021-pol2qm74 7606 16 either either CC cord-015021-pol2qm74 7606 17 nothing nothing NN cord-015021-pol2qm74 7606 18 , , , cord-015021-pol2qm74 7606 19 an an DT cord-015021-pol2qm74 7606 20 isotype isotype NN cord-015021-pol2qm74 7606 21 control control NN cord-015021-pol2qm74 7606 22 or or CC cord-015021-pol2qm74 7606 23 anti anti JJ cord-015021-pol2qm74 7606 24 - - JJ cord-015021-pol2qm74 7606 25 CD14 cd14 JJ cord-015021-pol2qm74 7606 26 mAb mAb NNS cord-015021-pol2qm74 7606 27 ( ( -LRB- cord-015021-pol2qm74 7606 28 5mg 5mg NNP cord-015021-pol2qm74 7606 29 / / SYM cord-015021-pol2qm74 7606 30 kg kg NN cord-015021-pol2qm74 7606 31 ) ) -RRB- cord-015021-pol2qm74 7606 32 30 30 CD cord-015021-pol2qm74 7606 33 rains rain NNS cord-015021-pol2qm74 7606 34 , , , cord-015021-pol2qm74 7606 35 prior prior RB cord-015021-pol2qm74 7606 36 to to IN cord-015021-pol2qm74 7606 37 the the DT cord-015021-pol2qm74 7606 38 beginning beginning NN cord-015021-pol2qm74 7606 39 of of IN cord-015021-pol2qm74 7606 40 the the DT cord-015021-pol2qm74 7606 41 LPS LPS NNP cord-015021-pol2qm74 7606 42 infusion infusion NN cord-015021-pol2qm74 7606 43 . . . cord-015021-pol2qm74 7607 1 Evaluation evaluation NN cord-015021-pol2qm74 7607 2 of of IN cord-015021-pol2qm74 7607 3 physiologic physiologic JJ cord-015021-pol2qm74 7607 4 changes change NNS cord-015021-pol2qm74 7607 5 including include VBG cord-015021-pol2qm74 7607 6 mean mean VBP cord-015021-pol2qm74 7607 7 arterial arterial JJ cord-015021-pol2qm74 7607 8 blood blood NN cord-015021-pol2qm74 7607 9 pressure pressure NN cord-015021-pol2qm74 7607 10 and and CC cord-015021-pol2qm74 7607 11 cardiac cardiac JJ cord-015021-pol2qm74 7607 12 output output NN cord-015021-pol2qm74 7607 13 , , , cord-015021-pol2qm74 7607 14 quantitative quantitative JJ cord-015021-pol2qm74 7607 15 analysis analysis NN cord-015021-pol2qm74 7607 16 of of IN cord-015021-pol2qm74 7607 17 eytoldne eytoldne JJ cord-015021-pol2qm74 7607 18 levels level NNS cord-015021-pol2qm74 7607 19 including include VBG cord-015021-pol2qm74 7607 20 TNFct TNFct NNP cord-015021-pol2qm74 7607 21 , , , cord-015021-pol2qm74 7607 22 IL-113,1I,-6 IL-113,1I,-6 NNP cord-015021-pol2qm74 7607 23 , , , cord-015021-pol2qm74 7607 24 IL-8 IL-8 NNP cord-015021-pol2qm74 7607 25 and and CC cord-015021-pol2qm74 7607 26 IL-10 IL-10 NNP cord-015021-pol2qm74 7607 27 , , , cord-015021-pol2qm74 7607 28 and and CC cord-015021-pol2qm74 7607 29 liver liver NN cord-015021-pol2qm74 7607 30 enzymes enzyme NNS cord-015021-pol2qm74 7607 31 during during IN cord-015021-pol2qm74 7607 32 a a DT cord-015021-pol2qm74 7607 33 24 24 CD cord-015021-pol2qm74 7607 34 hour hour NN cord-015021-pol2qm74 7607 35 period period NN cord-015021-pol2qm74 7607 36 revealed reveal VBD cord-015021-pol2qm74 7607 37 that that IN cord-015021-pol2qm74 7607 38 treatment treatment NN cord-015021-pol2qm74 7607 39 with with IN cord-015021-pol2qm74 7607 40 anti anti JJ cord-015021-pol2qm74 7607 41 - - JJ cord-015021-pol2qm74 7607 42 CD14 cd14 JJ cord-015021-pol2qm74 7607 43 mAb mAb NNS cord-015021-pol2qm74 7607 44 markedly markedly RB cord-015021-pol2qm74 7607 45 attenuated attenuate VBD cord-015021-pol2qm74 7607 46 all all DT cord-015021-pol2qm74 7607 47 parameters parameter NNS cord-015021-pol2qm74 7607 48 of of IN cord-015021-pol2qm74 7607 49 injury injury NN cord-015021-pol2qm74 7607 50 including include VBG cord-015021-pol2qm74 7607 51 decreased decrease VBD cord-015021-pol2qm74 7607 52 mean mean JJ cord-015021-pol2qm74 7607 53 arterial arterial JJ cord-015021-pol2qm74 7607 54 blood blood NN cord-015021-pol2qm74 7607 55 pressure pressure NN cord-015021-pol2qm74 7607 56 , , , cord-015021-pol2qm74 7607 57 increased increase VBN cord-015021-pol2qm74 7607 58 cytnkine cytnkine NN cord-015021-pol2qm74 7607 59 levels level NNS cord-015021-pol2qm74 7607 60 and and CC cord-015021-pol2qm74 7607 61 the the DT cord-015021-pol2qm74 7607 62 release release NN cord-015021-pol2qm74 7607 63 of of IN cord-015021-pol2qm74 7607 64 liver liver NN cord-015021-pol2qm74 7607 65 enzymes enzyme NNS cord-015021-pol2qm74 7607 66 observed observe VBN cord-015021-pol2qm74 7607 67 in in IN cord-015021-pol2qm74 7607 68 animals animal NNS cord-015021-pol2qm74 7607 69 given give VBN cord-015021-pol2qm74 7607 70 the the DT cord-015021-pol2qm74 7607 71 isotype isotype NN cord-015021-pol2qm74 7607 72 control control NN cord-015021-pol2qm74 7607 73 mAb mAb NNS cord-015021-pol2qm74 7607 74 or or CC cord-015021-pol2qm74 7607 75 those those DT cord-015021-pol2qm74 7607 76 not not RB cord-015021-pol2qm74 7607 77 treated treat VBN cord-015021-pol2qm74 7607 78 . . . cord-015021-pol2qm74 7608 1 Administration Administration NNP cord-015021-pol2qm74 7608 2 of of IN cord-015021-pol2qm74 7608 3 anti anti JJ cord-015021-pol2qm74 7608 4 - - JJ cord-015021-pol2qm74 7608 5 CD14 cd14 JJ cord-015021-pol2qm74 7608 6 mAb mAb NNS cord-015021-pol2qm74 7608 7 to to IN cord-015021-pol2qm74 7608 8 interferon interferon NN cord-015021-pol2qm74 7608 9 - - HYPH cord-015021-pol2qm74 7608 10 gamma gamma NN cord-015021-pol2qm74 7608 11 treated treat VBN cord-015021-pol2qm74 7608 12 animals animal NNS cord-015021-pol2qm74 7608 13 NOT not RB cord-015021-pol2qm74 7608 14 challenged challenge VBN cord-015021-pol2qm74 7608 15 with with IN cord-015021-pol2qm74 7608 16 LPS LPS NNP cord-015021-pol2qm74 7608 17 did do VBD cord-015021-pol2qm74 7608 18 not not RB cord-015021-pol2qm74 7608 19 induce induce VB cord-015021-pol2qm74 7608 20 any any DT cord-015021-pol2qm74 7608 21 detectable detectable JJ cord-015021-pol2qm74 7608 22 physiologic physiologic JJ cord-015021-pol2qm74 7608 23 changes change NNS cord-015021-pol2qm74 7608 24 or or CC cord-015021-pol2qm74 7608 25 increases increase NNS cord-015021-pol2qm74 7608 26 in in IN cord-015021-pol2qm74 7608 27 cytoldnes cytoldne NNS cord-015021-pol2qm74 7608 28 . . . cord-015021-pol2qm74 7609 1 These these DT cord-015021-pol2qm74 7609 2 studies study NNS cord-015021-pol2qm74 7609 3 suggest suggest VBP cord-015021-pol2qm74 7609 4 that that IN cord-015021-pol2qm74 7609 5 strategies strategy NNS cord-015021-pol2qm74 7609 6 to to TO cord-015021-pol2qm74 7609 7 block block VB cord-015021-pol2qm74 7609 8 LPS LPS NNP cord-015021-pol2qm74 7609 9 - - HYPH cord-015021-pol2qm74 7609 10 CD14 CD14 NNP cord-015021-pol2qm74 7609 11 interactions interaction NNS cord-015021-pol2qm74 7609 12 will will MD cord-015021-pol2qm74 7609 13 have have VB cord-015021-pol2qm74 7609 14 utility utility NN cord-015021-pol2qm74 7609 15 in in IN cord-015021-pol2qm74 7609 16 diseases disease NNS cord-015021-pol2qm74 7609 17 such such JJ cord-015021-pol2qm74 7609 18 as as IN cord-015021-pol2qm74 7609 19 septic septic JJ cord-015021-pol2qm74 7609 20 shock shock NN cord-015021-pol2qm74 7609 21 or or CC cord-015021-pol2qm74 7609 22 ARDS ARDS NNP cord-015021-pol2qm74 7609 23 where where WRB cord-015021-pol2qm74 7609 24 LPS LPS NNP cord-015021-pol2qm74 7609 25 plays play VBZ cord-015021-pol2qm74 7609 26 a a DT cord-015021-pol2qm74 7609 27 central central JJ cord-015021-pol2qm74 7609 28 role role NN cord-015021-pol2qm74 7609 29 in in IN cord-015021-pol2qm74 7609 30 initiating initiate VBG cord-015021-pol2qm74 7609 31 injury injury NN cord-015021-pol2qm74 7609 32 . . . cord-015021-pol2qm74 7610 1 Preclinical Preclinical NNP cord-015021-pol2qm74 7610 2 Studies Studies NNPS cord-015021-pol2qm74 7610 3 with with IN cord-015021-pol2qm74 7610 4 Recombinant Recombinant NNP cord-015021-pol2qm74 7610 5 Bactericidal Bactericidal NNP cord-015021-pol2qm74 7610 6 / / SYM cord-015021-pol2qm74 7610 7 Permeability Permeability NNP cord-015021-pol2qm74 7610 8 Increasing increase VBG cord-015021-pol2qm74 7610 9 Proteins protein NNS cord-015021-pol2qm74 7610 10 ( ( -LRB- cord-015021-pol2qm74 7610 11 rBPI rbpi NN cord-015021-pol2qm74 7610 12 and and CC cord-015021-pol2qm74 7610 13 rBPI23 rBPI23 NNP cord-015021-pol2qm74 7610 14 ) ) -RRB- cord-015021-pol2qm74 7610 15 . . . cord-015021-pol2qm74 7611 1 P.W. P.W. NNP cord-015021-pol2qm74 7611 2 " " `` cord-015021-pol2qm74 7611 3 Frown Frown NNP cord-015021-pol2qm74 7611 4 , , , cord-015021-pol2qm74 7611 5 Dept Dept NNP cord-015021-pol2qm74 7611 6 . . NNP cord-015021-pol2qm74 7611 7 of of IN cord-015021-pol2qm74 7611 8 Preclinical Preclinical NNP cord-015021-pol2qm74 7611 9 Science Science NNP cord-015021-pol2qm74 7611 10 , , , cord-015021-pol2qm74 7611 11 XOMA XOMA NNP cord-015021-pol2qm74 7611 12 Corporation Corporation NNP cord-015021-pol2qm74 7611 13 , , , cord-015021-pol2qm74 7611 14 Berkeley Berkeley NNP cord-015021-pol2qm74 7611 15 , , , cord-015021-pol2qm74 7611 16 California California NNP cord-015021-pol2qm74 7611 17 , , , cord-015021-pol2qm74 7611 18 USA USA NNP cord-015021-pol2qm74 7611 19 . . . cord-015021-pol2qm74 7612 1 Bactericidal bactericidal JJ cord-015021-pol2qm74 7612 2 / / SYM cord-015021-pol2qm74 7612 3 permeability permeability NN cord-015021-pol2qm74 7612 4 increasing increase VBG cord-015021-pol2qm74 7612 5 protein protein NN cord-015021-pol2qm74 7612 6 ( ( -LRB- cord-015021-pol2qm74 7612 7 BPI BPI NNP cord-015021-pol2qm74 7612 8 ) ) -RRB- cord-015021-pol2qm74 7612 9 , , , cord-015021-pol2qm74 7612 10 from from IN cord-015021-pol2qm74 7612 11 neutrophils neutrophil NNS cord-015021-pol2qm74 7612 12 , , , cord-015021-pol2qm74 7612 13 binds bind VBZ cord-015021-pol2qm74 7612 14 to to IN cord-015021-pol2qm74 7612 15 and and CC cord-015021-pol2qm74 7612 16 neutralizes neutralize VBZ cord-015021-pol2qm74 7612 17 lipopolysaccharide lipopolysaccharide NN cord-015021-pol2qm74 7612 18 ( ( -LRB- cord-015021-pol2qm74 7612 19 LPS LPS NNP cord-015021-pol2qm74 7612 20 ) ) -RRB- cord-015021-pol2qm74 7612 21 ; ; : cord-015021-pol2qm74 7612 22 it -PRON- PRP cord-015021-pol2qm74 7612 23 also also RB cord-015021-pol2qm74 7612 24 specifically specifically RB cord-015021-pol2qm74 7612 25 kills kill VBZ cord-015021-pol2qm74 7612 26 gram gram NN cord-015021-pol2qm74 7612 27 - - HYPH cord-015021-pol2qm74 7612 28 negative negative JJ cord-015021-pol2qm74 7612 29 bacteria bacteria NNS cord-015021-pol2qm74 7612 30 ( ( -LRB- cord-015021-pol2qm74 7612 31 GNB GNB NNP cord-015021-pol2qm74 7612 32 ) ) -RRB- cord-015021-pol2qm74 7612 33 . . . cord-015021-pol2qm74 7613 1 These these DT cord-015021-pol2qm74 7613 2 properties property NNS cord-015021-pol2qm74 7613 3 , , , cord-015021-pol2qm74 7613 4 which which WDT cord-015021-pol2qm74 7613 5 reside reside VBP cord-015021-pol2qm74 7613 6 in in IN cord-015021-pol2qm74 7613 7 the the DT cord-015021-pol2qm74 7613 8 N n CD cord-015021-pol2qm74 7613 9 - - HYPH cord-015021-pol2qm74 7613 10 terminal terminal JJ cord-015021-pol2qm74 7613 11 half half NN cord-015021-pol2qm74 7613 12 of of IN cord-015021-pol2qm74 7613 13 the the DT cord-015021-pol2qm74 7613 14 molecule molecule NN cord-015021-pol2qm74 7613 15 , , , cord-015021-pol2qm74 7613 16 indicate indicate VBP cord-015021-pol2qm74 7613 17 potential potential JJ cord-015021-pol2qm74 7613 18 therapeutic therapeutic JJ cord-015021-pol2qm74 7613 19 application application NN cord-015021-pol2qm74 7613 20 in in IN cord-015021-pol2qm74 7613 21 the the DT cord-015021-pol2qm74 7613 22 treatment treatment NN cord-015021-pol2qm74 7613 23 of of IN cord-015021-pol2qm74 7613 24 gram gram NN cord-015021-pol2qm74 7613 25 - - HYPH cord-015021-pol2qm74 7613 26 negative negative JJ cord-015021-pol2qm74 7613 27 sepsis sepsis NN cord-015021-pol2qm74 7613 28 . . . cord-015021-pol2qm74 7614 1 The the DT cord-015021-pol2qm74 7614 2 gene gene NN cord-015021-pol2qm74 7614 3 for for IN cord-015021-pol2qm74 7614 4 human human JJ cord-015021-pol2qm74 7614 5 BPI BPI NNP cord-015021-pol2qm74 7614 6 has have VBZ cord-015021-pol2qm74 7614 7 been be VBN cord-015021-pol2qm74 7614 8 cloned clone VBN cord-015021-pol2qm74 7614 9 and and CC cord-015021-pol2qm74 7614 10 recombinant recombinant JJ cord-015021-pol2qm74 7614 11 holoprotein holoprotein NNP cord-015021-pol2qm74 7614 12 ( ( -LRB- cord-015021-pol2qm74 7614 13 rBPI rBPI NNP cord-015021-pol2qm74 7614 14 ) ) -RRB- cord-015021-pol2qm74 7614 15 and and CC cord-015021-pol2qm74 7614 16 a a DT cord-015021-pol2qm74 7614 17 23 23 CD cord-015021-pol2qm74 7614 18 Kd Kd NNP cord-015021-pol2qm74 7614 19 N N NNP cord-015021-pol2qm74 7614 20 - - HYPH cord-015021-pol2qm74 7614 21 terminal terminal NN cord-015021-pol2qm74 7614 22 fragment fragment NN cord-015021-pol2qm74 7614 23 ( ( -LRB- cord-015021-pol2qm74 7614 24 rBPI;3 rbpi;3 NN cord-015021-pol2qm74 7614 25 ) ) -RRB- cord-015021-pol2qm74 7614 26 have have VBP cord-015021-pol2qm74 7614 27 been be VBN cord-015021-pol2qm74 7614 28 produced produce VBN cord-015021-pol2qm74 7614 29 in in IN cord-015021-pol2qm74 7614 30 sufficient sufficient JJ cord-015021-pol2qm74 7614 31 quantities quantity NNS cord-015021-pol2qm74 7614 32 for for IN cord-015021-pol2qm74 7614 33 preclinical preclinical JJ cord-015021-pol2qm74 7614 34 studies study NNS cord-015021-pol2qm74 7614 35 . . . cord-015021-pol2qm74 7615 1 Both both DT cord-015021-pol2qm74 7615 2 rBPI rbpi NN cord-015021-pol2qm74 7615 3 and and CC cord-015021-pol2qm74 7615 4 rBPI23 rBPI23 NNP cord-015021-pol2qm74 7615 5 bind bind VBP cord-015021-pol2qm74 7615 6 to to IN cord-015021-pol2qm74 7615 7 lipid lipid NN cord-015021-pol2qm74 7615 8 A a NN cord-015021-pol2qm74 7615 9 and and CC cord-015021-pol2qm74 7615 10 neutralize neutralize VB cord-015021-pol2qm74 7615 11 the the DT cord-015021-pol2qm74 7615 12 biological biological JJ cord-015021-pol2qm74 7615 13 activities activity NNS cord-015021-pol2qm74 7615 14 of of IN cord-015021-pol2qm74 7615 15 LPS LPS NNP cord-015021-pol2qm74 7615 16 derived derive VBN cord-015021-pol2qm74 7615 17 from from IN cord-015021-pol2qm74 7615 18 a a DT cord-015021-pol2qm74 7615 19 variety variety NN cord-015021-pol2qm74 7615 20 of of IN cord-015021-pol2qm74 7615 21 organisms organism NNS cord-015021-pol2qm74 7615 22 , , , cord-015021-pol2qm74 7615 23 rBPI23 rBPI23 NNP cord-015021-pol2qm74 7615 24 has have VBZ cord-015021-pol2qm74 7615 25 equivalent equivalent JJ cord-015021-pol2qm74 7615 26 antibacterial antibacterial JJ cord-015021-pol2qm74 7615 27 activity activity NN cord-015021-pol2qm74 7615 28 to to IN cord-015021-pol2qm74 7615 29 BPI BPI NNP cord-015021-pol2qm74 7615 30 against against IN cord-015021-pol2qm74 7615 31 rough rough JJ cord-015021-pol2qm74 7615 32 GNB GNB NNP cord-015021-pol2qm74 7615 33 but but CC cord-015021-pol2qm74 7615 34 is be VBZ cord-015021-pol2qm74 7615 35 up up RB cord-015021-pol2qm74 7615 36 to to TO cord-015021-pol2qm74 7615 37 30X 30X NNS cord-015021-pol2qm74 7615 38 more more RBR cord-015021-pol2qm74 7615 39 potent potent JJ cord-015021-pol2qm74 7615 40 than than IN cord-015021-pol2qm74 7615 41 BPI BPI NNP cord-015021-pol2qm74 7615 42 vs. vs. IN cord-015021-pol2qm74 7615 43 serum serum NN cord-015021-pol2qm74 7615 44 - - HYPH cord-015021-pol2qm74 7615 45 resistant resistant JJ cord-015021-pol2qm74 7615 46 and and CC cord-015021-pol2qm74 7615 47 smooth smooth JJ cord-015021-pol2qm74 7615 48 GNB GNB NNP cord-015021-pol2qm74 7615 49 . . . cord-015021-pol2qm74 7616 1 rBPI rBPI NNP cord-015021-pol2qm74 7616 2 and and CC cord-015021-pol2qm74 7616 3 rBPI23 rBPI23 NNP cord-015021-pol2qm74 7616 4 compete compete VBP cord-015021-pol2qm74 7616 5 with with IN cord-015021-pol2qm74 7616 6 LPS LPS NNP cord-015021-pol2qm74 7616 7 - - HYPH cord-015021-pol2qm74 7616 8 binding bind VBG cord-015021-pol2qm74 7616 9 protein protein NN cord-015021-pol2qm74 7616 10 ( ( -LRB- cord-015021-pol2qm74 7616 11 LBP LBP NNP cord-015021-pol2qm74 7616 12 ) ) -RRB- cord-015021-pol2qm74 7616 13 for for IN cord-015021-pol2qm74 7616 14 binding bind VBG cord-015021-pol2qm74 7616 15 to to IN cord-015021-pol2qm74 7616 16 LPS lp NNS cord-015021-pol2qm74 7616 17 under under IN cord-015021-pol2qm74 7616 18 physiological physiological JJ cord-015021-pol2qm74 7616 19 conditions condition NNS cord-015021-pol2qm74 7616 20 . . . cord-015021-pol2qm74 7617 1 Consequently consequently RB cord-015021-pol2qm74 7617 2 , , , cord-015021-pol2qm74 7617 3 both both CC cord-015021-pol2qm74 7617 4 rBPI rbpi NN cord-015021-pol2qm74 7617 5 and and CC cord-015021-pol2qm74 7617 6 rBPI23 rBPI23 NNP cord-015021-pol2qm74 7617 7 block block VB cord-015021-pol2qm74 7617 8 the the DT cord-015021-pol2qm74 7617 9 CD14-dependent cd14-dependent CD cord-015021-pol2qm74 7617 10 LPSinduced lpsinduced JJ cord-015021-pol2qm74 7617 11 synthesis synthesis NN cord-015021-pol2qm74 7617 12 of of IN cord-015021-pol2qm74 7617 13 the the DT cord-015021-pol2qm74 7617 14 cytokines cytokine NNS cord-015021-pol2qm74 7617 15 TNF TNF NNP cord-015021-pol2qm74 7617 16 , , , cord-015021-pol2qm74 7617 17 IL-1 IL-1 NNP cord-015021-pol2qm74 7617 18 , , , cord-015021-pol2qm74 7617 19 EL-6 EL-6 NNP cord-015021-pol2qm74 7617 20 and and CC cord-015021-pol2qm74 7617 21 IL-8 IL-8 NNP cord-015021-pol2qm74 7617 22 in in IN cord-015021-pol2qm74 7617 23 vitro vitro FW cord-015021-pol2qm74 7617 24 . . . cord-015021-pol2qm74 7618 1 rBPI23 rBPI23 NNP cord-015021-pol2qm74 7618 2 has have VBZ cord-015021-pol2qm74 7618 3 also also RB cord-015021-pol2qm74 7618 4 been be VBN cord-015021-pol2qm74 7618 5 shown show VBN cord-015021-pol2qm74 7618 6 to to TO cord-015021-pol2qm74 7618 7 inhibit inhibit VB cord-015021-pol2qm74 7618 8 the the DT cord-015021-pol2qm74 7618 9 LPS LPS NNP cord-015021-pol2qm74 7618 10 - - HYPH cord-015021-pol2qm74 7618 11 induced induce VBN cord-015021-pol2qm74 7618 12 synthesis synthesis NN cord-015021-pol2qm74 7618 13 of of IN cord-015021-pol2qm74 7618 14 reactive reactive JJ cord-015021-pol2qm74 7618 15 02 02 CD cord-015021-pol2qm74 7618 16 metabolites metabolite NNS cord-015021-pol2qm74 7618 17 , , , cord-015021-pol2qm74 7618 18 endothelial endothelial JJ cord-015021-pol2qm74 7618 19 adhesion adhesion NN cord-015021-pol2qm74 7618 20 molecules molecule NNS cord-015021-pol2qm74 7618 21 and and CC cord-015021-pol2qm74 7618 22 the the DT cord-015021-pol2qm74 7618 23 procoagulant procoagulant NN cord-015021-pol2qm74 7618 24 molecule molecule NN cord-015021-pol2qm74 7618 25 tissue tissue NN cord-015021-pol2qm74 7618 26 factor factor NN cord-015021-pol2qm74 7618 27 . . . cord-015021-pol2qm74 7619 1 In in IN cord-015021-pol2qm74 7619 2 animals animal NNS cord-015021-pol2qm74 7619 3 , , , cord-015021-pol2qm74 7619 4 rBPI rbpi NN cord-015021-pol2qm74 7619 5 has have VBZ cord-015021-pol2qm74 7619 6 been be VBN cord-015021-pol2qm74 7619 7 reported report VBN cord-015021-pol2qm74 7619 8 to to TO cord-015021-pol2qm74 7619 9 increase increase VB cord-015021-pol2qm74 7619 10 survival survival NN cord-015021-pol2qm74 7619 11 of of IN cord-015021-pol2qm74 7619 12 endotoxin endotoxin NN cord-015021-pol2qm74 7619 13 - - HYPH cord-015021-pol2qm74 7619 14 challenged challenge VBN cord-015021-pol2qm74 7619 15 rats rat NNS cord-015021-pol2qm74 7619 16 and and CC cord-015021-pol2qm74 7619 17 mice mouse NNS cord-015021-pol2qm74 7619 18 , , , cord-015021-pol2qm74 7619 19 to to TO cord-015021-pol2qm74 7619 20 inhibit inhibit VB cord-015021-pol2qm74 7619 21 the the DT cord-015021-pol2qm74 7619 22 dermal dermal JJ cord-015021-pol2qm74 7619 23 Schwartzman Schwartzman NNP cord-015021-pol2qm74 7619 24 reaction reaction NN cord-015021-pol2qm74 7619 25 in in IN cord-015021-pol2qm74 7619 26 rabbits rabbit NNS cord-015021-pol2qm74 7619 27 and and CC cord-015021-pol2qm74 7619 28 to to TO cord-015021-pol2qm74 7619 29 increase increase VB cord-015021-pol2qm74 7619 30 survival survival NN cord-015021-pol2qm74 7619 31 of of IN cord-015021-pol2qm74 7619 32 neutropenic neutropenic JJ cord-015021-pol2qm74 7619 33 rats rat NNS cord-015021-pol2qm74 7619 34 with with IN cord-015021-pol2qm74 7619 35 Pseudomonas Pseudomonas NNP cord-015021-pol2qm74 7619 36 bacteremia bacteremia NN cord-015021-pol2qm74 7619 37 , , , cord-015021-pol2qm74 7619 38 rBPI23 rBPI23 NNP cord-015021-pol2qm74 7619 39 increases increase VBZ cord-015021-pol2qm74 7619 40 survival survival NN cord-015021-pol2qm74 7619 41 and and CC cord-015021-pol2qm74 7619 42 decreases decrease VBZ cord-015021-pol2qm74 7619 43 cytokine cytokine NN cord-015021-pol2qm74 7619 44 production production NN cord-015021-pol2qm74 7619 45 in in IN cord-015021-pol2qm74 7619 46 endotoxin endotoxin NN cord-015021-pol2qm74 7619 47 challenged challenge VBD cord-015021-pol2qm74 7619 48 mice mouse NNS cord-015021-pol2qm74 7619 49 and and CC cord-015021-pol2qm74 7619 50 rats rat NNS cord-015021-pol2qm74 7619 51 . . . cord-015021-pol2qm74 7620 1 It -PRON- PRP cord-015021-pol2qm74 7620 2 normalizes normalize VBZ cord-015021-pol2qm74 7620 3 LPS LPS NNP cord-015021-pol2qm74 7620 4 - - HYPH cord-015021-pol2qm74 7620 5 induced induce VBN cord-015021-pol2qm74 7620 6 changes change NNS cord-015021-pol2qm74 7620 7 in in IN cord-015021-pol2qm74 7620 8 hemodynamic hemodynamic JJ cord-015021-pol2qm74 7620 9 , , , cord-015021-pol2qm74 7620 10 pulmonary pulmonary JJ cord-015021-pol2qm74 7620 11 and/or and/or CC cord-015021-pol2qm74 7620 12 metabolic metabolic JJ cord-015021-pol2qm74 7620 13 parameters parameter NNS cord-015021-pol2qm74 7620 14 in in IN cord-015021-pol2qm74 7620 15 LPS LPS NNP cord-015021-pol2qm74 7620 16 - - HYPH cord-015021-pol2qm74 7620 17 induced induce VBN cord-015021-pol2qm74 7620 18 rats rat NNS cord-015021-pol2qm74 7620 19 , , , cord-015021-pol2qm74 7620 20 rabbits rabbit NNS cord-015021-pol2qm74 7620 21 and and CC cord-015021-pol2qm74 7620 22 pigs pig NNS cord-015021-pol2qm74 7620 23 . . . cord-015021-pol2qm74 7621 1 Treatment treatment NN cord-015021-pol2qm74 7621 2 with with IN cord-015021-pol2qm74 7621 3 rBPI23 rBPI23 NNP cord-015021-pol2qm74 7621 4 also also RB cord-015021-pol2qm74 7621 5 increases increase VBZ cord-015021-pol2qm74 7621 6 survival survival NN cord-015021-pol2qm74 7621 7 and and CC cord-015021-pol2qm74 7621 8 decreases decrease VBZ cord-015021-pol2qm74 7621 9 cytokine cytokine NN cord-015021-pol2qm74 7621 10 production production NN cord-015021-pol2qm74 7621 11 in in IN cord-015021-pol2qm74 7621 12 bacterial bacterial JJ cord-015021-pol2qm74 7621 13 challenge challenge NN cord-015021-pol2qm74 7621 14 models model NNS cord-015021-pol2qm74 7621 15 in in IN cord-015021-pol2qm74 7621 16 rats rat NNS cord-015021-pol2qm74 7621 17 and and CC cord-015021-pol2qm74 7621 18 mice mouse NNS cord-015021-pol2qm74 7621 19 . . . cord-015021-pol2qm74 7622 1 rBPI23 rBPI23 NNP cord-015021-pol2qm74 7622 2 was be VBD cord-015021-pol2qm74 7622 3 not not RB cord-015021-pol2qm74 7622 4 toxic toxic JJ cord-015021-pol2qm74 7622 5 to to IN cord-015021-pol2qm74 7622 6 rats rat NNS cord-015021-pol2qm74 7622 7 after after IN cord-015021-pol2qm74 7622 8 10 10 CD cord-015021-pol2qm74 7622 9 daily daily JJ cord-015021-pol2qm74 7622 10 consecutive consecutive JJ cord-015021-pol2qm74 7622 11 i.v i.v NNP cord-015021-pol2qm74 7622 12 . . . cord-015021-pol2qm74 7622 13 doses dose NNS cord-015021-pol2qm74 7622 14 of of IN cord-015021-pol2qm74 7622 15 10 10 CD cord-015021-pol2qm74 7622 16 mg mg NNP cord-015021-pol2qm74 7622 17 / / SYM cord-015021-pol2qm74 7622 18 kg kg NN cord-015021-pol2qm74 7622 19 . . . cord-015021-pol2qm74 7623 1 This this DT cord-015021-pol2qm74 7623 2 combination combination NN cord-015021-pol2qm74 7623 3 of of IN cord-015021-pol2qm74 7623 4 properties property NNS cord-015021-pol2qm74 7623 5 indicate indicate VBP cord-015021-pol2qm74 7623 6 that that IN cord-015021-pol2qm74 7623 7 recombinant recombinant JJ cord-015021-pol2qm74 7623 8 BPI BPI NNP cord-015021-pol2qm74 7623 9 may may MD cord-015021-pol2qm74 7623 10 be be VB cord-015021-pol2qm74 7623 11 useful useful JJ cord-015021-pol2qm74 7623 12 in in IN cord-015021-pol2qm74 7623 13 the the DT cord-015021-pol2qm74 7623 14 treatment treatment NN cord-015021-pol2qm74 7623 15 of of IN cord-015021-pol2qm74 7623 16 sepsis sepsis NN cord-015021-pol2qm74 7623 17 . . . cord-015021-pol2qm74 7624 1 Phase phase NN cord-015021-pol2qm74 7624 2 I I NNP cord-015021-pol2qm74 7624 3 / / SYM cord-015021-pol2qm74 7624 4 II II NNP cord-015021-pol2qm74 7624 5 clinical clinical JJ cord-015021-pol2qm74 7624 6 trials trial NNS cord-015021-pol2qm74 7624 7 of of IN cord-015021-pol2qm74 7624 8 rBPI23 rBPI23 NNP cord-015021-pol2qm74 7624 9 have have VBP cord-015021-pol2qm74 7624 10 begun begin VBN cord-015021-pol2qm74 7624 11 . . . cord-015021-pol2qm74 7625 1 The the DT cord-015021-pol2qm74 7625 2 discovery discovery NN cord-015021-pol2qm74 7625 3 of of IN cord-015021-pol2qm74 7625 4 LPS LPS NNP cord-015021-pol2qm74 7625 5 binding bind VBG cord-015021-pol2qm74 7625 6 protein protein NN cord-015021-pol2qm74 7625 7 ( ( -LRB- cord-015021-pol2qm74 7625 8 LBP LBP NNP cord-015021-pol2qm74 7625 9 ) ) -RRB- cord-015021-pol2qm74 7625 10 and and CC cord-015021-pol2qm74 7625 11 subsequent subsequent JJ cord-015021-pol2qm74 7625 12 identification identification NN cord-015021-pol2qm74 7625 13 of of IN cord-015021-pol2qm74 7625 14 CD14 CD14 NNP cord-015021-pol2qm74 7625 15 as as IN cord-015021-pol2qm74 7625 16 a a DT cord-015021-pol2qm74 7625 17 receptor receptor NN cord-015021-pol2qm74 7625 18 for for IN cord-015021-pol2qm74 7625 19 LPS LPS NNP cord-015021-pol2qm74 7625 20 or or CC cord-015021-pol2qm74 7625 21 LPS LPS NNP cord-015021-pol2qm74 7625 22 - - HYPH cord-015021-pol2qm74 7625 23 LBP LBP NNP cord-015021-pol2qm74 7625 24 complexes complex NNS cord-015021-pol2qm74 7625 25 has have VBZ cord-015021-pol2qm74 7625 26 resulted result VBN cord-015021-pol2qm74 7625 27 in in IN cord-015021-pol2qm74 7625 28 a a DT cord-015021-pol2qm74 7625 29 new new JJ cord-015021-pol2qm74 7625 30 understanding understanding NN cord-015021-pol2qm74 7625 31 o£ o£ IN cord-015021-pol2qm74 7625 32 how how WRB cord-015021-pol2qm74 7625 33 LPS LPS NNP cord-015021-pol2qm74 7625 34 responsive responsive JJ cord-015021-pol2qm74 7625 35 ceils ceil NNS cord-015021-pol2qm74 7625 36 are be VBP cord-015021-pol2qm74 7625 37 stimulated stimulate VBN cord-015021-pol2qm74 7625 38 . . . cord-015021-pol2qm74 7626 1 CD14 CD14 NNP cord-015021-pol2qm74 7626 2 is be VBZ cord-015021-pol2qm74 7626 3 found find VBN cord-015021-pol2qm74 7626 4 either either CC cord-015021-pol2qm74 7626 5 as as IN cord-015021-pol2qm74 7626 6 a a DT cord-015021-pol2qm74 7626 7 glycosylphosphatidyl glycosylphosphatidyl NN cord-015021-pol2qm74 7626 8 - - HYPH cord-015021-pol2qm74 7626 9 inositol inositol JJ cord-015021-pol2qm74 7626 10 ( ( -LRB- cord-015021-pol2qm74 7626 11 GPI)-anehored gpi)-anehore VBN cord-015021-pol2qm74 7626 12 membrane membrane NN cord-015021-pol2qm74 7626 13 glycoprotein glycoprotein NN cord-015021-pol2qm74 7626 14 ( ( -LRB- cord-015021-pol2qm74 7626 15 mCD14 mCD14 NNP cord-015021-pol2qm74 7626 16 ) ) -RRB- cord-015021-pol2qm74 7626 17 of of IN cord-015021-pol2qm74 7626 18 myeloid myeloid NN cord-015021-pol2qm74 7626 19 cells cell NNS cord-015021-pol2qm74 7626 20 or or CC cord-015021-pol2qm74 7626 21 as as IN cord-015021-pol2qm74 7626 22 a a DT cord-015021-pol2qm74 7626 23 soluble soluble JJ cord-015021-pol2qm74 7626 24 serum serum NN cord-015021-pol2qm74 7626 25 protein protein NN cord-015021-pol2qm74 7626 26 ( ( -LRB- cord-015021-pol2qm74 7626 27 sCD14 sCD14 NNP cord-015021-pol2qm74 7626 28 ) ) -RRB- cord-015021-pol2qm74 7626 29 lacking lack VBG cord-015021-pol2qm74 7626 30 the the DT cord-015021-pol2qm74 7626 31 GPI GPI NNP cord-015021-pol2qm74 7626 32 - - HYPH cord-015021-pol2qm74 7626 33 anchor anchor NN cord-015021-pol2qm74 7626 34 . . . cord-015021-pol2qm74 7627 1 Binding bind VBG cord-015021-pol2qm74 7627 2 of of IN cord-015021-pol2qm74 7627 3 LPS LPS NNP cord-015021-pol2qm74 7627 4 to to TO cord-015021-pol2qm74 7627 5 mCD mcd VB cord-015021-pol2qm74 7627 6 14 14 CD cord-015021-pol2qm74 7627 7 triggers trigger VBZ cord-015021-pol2qm74 7627 8 cell cell NN cord-015021-pol2qm74 7627 9 activation activation NN cord-015021-pol2qm74 7627 10 while while IN cord-015021-pol2qm74 7627 11 binding bind VBG cord-015021-pol2qm74 7627 12 of of IN cord-015021-pol2qm74 7627 13 LPS LPS NNP cord-015021-pol2qm74 7627 14 - - HYPH cord-015021-pol2qm74 7627 15 sCD14 scd14 NN cord-015021-pol2qm74 7627 16 complexes complex NNS cord-015021-pol2qm74 7627 17 to to TO cord-015021-pol2qm74 7627 18 cells cell NNS cord-015021-pol2qm74 7627 19 such such JJ cord-015021-pol2qm74 7627 20 as as IN cord-015021-pol2qm74 7627 21 endothelial endothelial JJ cord-015021-pol2qm74 7627 22 or or CC cord-015021-pol2qm74 7627 23 epithelial epithelial JJ cord-015021-pol2qm74 7627 24 cells cell NNS cord-015021-pol2qm74 7627 25 that that WDT cord-015021-pol2qm74 7627 26 normally normally RB cord-015021-pol2qm74 7627 27 do do VBP cord-015021-pol2qm74 7627 28 not not RB cord-015021-pol2qm74 7627 29 express express VB cord-015021-pol2qm74 7627 30 mCD14 mCD14 NNP cord-015021-pol2qm74 7627 31 activates activate VBZ cord-015021-pol2qm74 7627 32 these these DT cord-015021-pol2qm74 7627 33 cells cell NNS cord-015021-pol2qm74 7627 34 . . . cord-015021-pol2qm74 7628 1 These these DT cord-015021-pol2qm74 7628 2 pathways pathway NNS cord-015021-pol2qm74 7628 3 are be VBP cord-015021-pol2qm74 7628 4 shown show VBN cord-015021-pol2qm74 7628 5 in in IN cord-015021-pol2qm74 7628 6 schematic schematic JJ cord-015021-pol2qm74 7628 7 form form NN cord-015021-pol2qm74 7628 8 below below RB cord-015021-pol2qm74 7628 9 . . . cord-015021-pol2qm74 7629 1 4 4 LS cord-015021-pol2qm74 7630 1 ~DI ~DI NFP cord-015021-pol2qm74 7631 1 mCD14 mCD14 NNP cord-015021-pol2qm74 7631 2 plays play VBZ cord-015021-pol2qm74 7631 3 a a DT cord-015021-pol2qm74 7631 4 crucial crucial JJ cord-015021-pol2qm74 7631 5 role role NN cord-015021-pol2qm74 7631 6 in in IN cord-015021-pol2qm74 7631 7 presentation presentation NN cord-015021-pol2qm74 7631 8 of of IN cord-015021-pol2qm74 7631 9 LPS lp NNS cord-015021-pol2qm74 7631 10 to to IN cord-015021-pol2qm74 7631 11 additional additional JJ cord-015021-pol2qm74 7631 12 membrane membrane NN cord-015021-pol2qm74 7631 13 components component NNS cord-015021-pol2qm74 7631 14 that that WDT cord-015021-pol2qm74 7631 15 make make VBP cord-015021-pol2qm74 7631 16 up up RP cord-015021-pol2qm74 7631 17 a a DT cord-015021-pol2qm74 7631 18 functional functional JJ cord-015021-pol2qm74 7631 19 LPS LPS NNP cord-015021-pol2qm74 7631 20 receptor receptor NN cord-015021-pol2qm74 7631 21 . . . cord-015021-pol2qm74 7632 1 An an DT cord-015021-pol2qm74 7632 2 immediate immediate JJ cord-015021-pol2qm74 7632 3 consequence consequence NN cord-015021-pol2qm74 7632 4 of of IN cord-015021-pol2qm74 7632 5 engagement engagement NN cord-015021-pol2qm74 7632 6 of of IN cord-015021-pol2qm74 7632 7 this this DT cord-015021-pol2qm74 7632 8 functional functional JJ cord-015021-pol2qm74 7632 9 receptor receptor NN cord-015021-pol2qm74 7632 10 is be VBZ cord-015021-pol2qm74 7632 11 protein protein NN cord-015021-pol2qm74 7632 12 tyrosine tyrosine NN cord-015021-pol2qm74 7632 13 phosphorylation phosphorylation NN cord-015021-pol2qm74 7632 14 . . . cord-015021-pol2qm74 7633 1 The the DT cord-015021-pol2qm74 7633 2 molecular molecular JJ cord-015021-pol2qm74 7633 3 mechanisms mechanism NNS cord-015021-pol2qm74 7633 4 leading lead VBG cord-015021-pol2qm74 7633 5 to to IN cord-015021-pol2qm74 7633 6 these these DT cord-015021-pol2qm74 7633 7 events event NNS cord-015021-pol2qm74 7633 8 will will MD cord-015021-pol2qm74 7633 9 be be VB cord-015021-pol2qm74 7633 10 discussed discuss VBN cord-015021-pol2qm74 7633 11 . . . cord-015021-pol2qm74 7634 1 Understanding understanding NN cord-015021-pol2qm74 7634 2 of of IN cord-015021-pol2qm74 7634 3 these these DT cord-015021-pol2qm74 7634 4 pathways pathway NNS cord-015021-pol2qm74 7634 5 will will MD cord-015021-pol2qm74 7634 6 lead lead VB cord-015021-pol2qm74 7634 7 to to IN cord-015021-pol2qm74 7634 8 the the DT cord-015021-pol2qm74 7634 9 development development NN cord-015021-pol2qm74 7634 10 of of IN cord-015021-pol2qm74 7634 11 new new JJ cord-015021-pol2qm74 7634 12 therapeutic therapeutic JJ cord-015021-pol2qm74 7634 13 approaches approach NNS cord-015021-pol2qm74 7634 14 to to IN cord-015021-pol2qm74 7634 15 controlling control VBG cord-015021-pol2qm74 7634 16 host host NN cord-015021-pol2qm74 7634 17 responses response NNS cord-015021-pol2qm74 7634 18 to to IN cord-015021-pol2qm74 7634 19 LPS lp NNS cord-015021-pol2qm74 7634 20 . . . cord-015021-pol2qm74 7635 1 Pretreatmen Pretreatmen NNP cord-015021-pol2qm74 7635 2 t t NNP cord-015021-pol2qm74 7635 3 Posttreatment Posttreatment NNP cord-015021-pol2qm74 7635 4 ( ( -LRB- cord-015021-pol2qm74 7635 5 before before IN cord-015021-pol2qm74 7635 6 or or CC cord-015021-pol2qm74 7635 7 after after IN cord-015021-pol2qm74 7635 8 TNF TNF NNP cord-015021-pol2qm74 7635 9 peak peak NN cord-015021-pol2qm74 7635 10 ) ) -RRB- cord-015021-pol2qm74 7635 11 D D NNP cord-015021-pol2qm74 7635 12 ) ) -RRB- cord-015021-pol2qm74 7635 13 with with IN cord-015021-pol2qm74 7635 14 different different JJ cord-015021-pol2qm74 7635 15 antibody antibody NN cord-015021-pol2qm74 7635 16 dosages dosage NNS cord-015021-pol2qm74 7635 17 : : : cord-015021-pol2qm74 7636 1 15 15 CD cord-015021-pol2qm74 7636 2 mg mg NNP cord-015021-pol2qm74 7636 3 / / SYM cord-015021-pol2qm74 7636 4 kg kg NNP cord-015021-pol2qm74 7637 1 ---0.1 ---0.1 NFP cord-015021-pol2qm74 7637 2 mg mg NNP cord-015021-pol2qm74 7637 3 / / SYM cord-015021-pol2qm74 7637 4 kg kg NNP cord-015021-pol2qm74 7638 1 Pretreatment pretreatment NN cord-015021-pol2qm74 7638 2 with with IN cord-015021-pol2qm74 7638 3 anti anti AFX cord-015021-pol2qm74 7638 4 - - JJ cord-015021-pol2qm74 7638 5 TNFab tnfab RB cord-015021-pol2qm74 7638 6 prevented prevent VBN cord-015021-pol2qm74 7638 7 death death NN cord-015021-pol2qm74 7638 8 in in IN cord-015021-pol2qm74 7638 9 most most JJS cord-015021-pol2qm74 7638 10 model model NN cord-015021-pol2qm74 7638 11 situations situation NNS cord-015021-pol2qm74 7638 12 ( ( -LRB- cord-015021-pol2qm74 7638 13 except except IN cord-015021-pol2qm74 7638 14 peritonitis peritonitis NN cord-015021-pol2qm74 7638 15 ) ) -RRB- cord-015021-pol2qm74 7638 16 , , , cord-015021-pol2qm74 7638 17 but but CC cord-015021-pol2qm74 7638 18 also also RB cord-015021-pol2qm74 7638 19 posttreatment posttreatment VB cord-015021-pol2qm74 7638 20 up up RP cord-015021-pol2qm74 7638 21 to to IN cord-015021-pol2qm74 7638 22 4h 4h CD cord-015021-pol2qm74 7638 23 after after IN cord-015021-pol2qm74 7638 24 sepsis sepsis NN cord-015021-pol2qm74 7638 25 induction induction NN cord-015021-pol2qm74 7638 26 was be VBD cord-015021-pol2qm74 7638 27 successful successful JJ cord-015021-pol2qm74 7638 28 in in IN cord-015021-pol2qm74 7638 29 the the DT cord-015021-pol2qm74 7638 30 few few JJ cord-015021-pol2qm74 7638 31 studies study NNS cord-015021-pol2qm74 7638 32 performed perform VBN cord-015021-pol2qm74 7638 33 . . . cord-015021-pol2qm74 7639 1 There there EX cord-015021-pol2qm74 7639 2 is be VBZ cord-015021-pol2qm74 7639 3 additional additional JJ cord-015021-pol2qm74 7639 4 evidence evidence NN cord-015021-pol2qm74 7639 5 that that IN cord-015021-pol2qm74 7639 6 low low JJ cord-015021-pol2qm74 7639 7 - - HYPH cord-015021-pol2qm74 7639 8 dose dose NN cord-015021-pol2qm74 7639 9 TNFab TNFab NNP cord-015021-pol2qm74 7639 10 is be VBZ cord-015021-pol2qm74 7639 11 partially partially RB cord-015021-pol2qm74 7639 12 effective effective JJ cord-015021-pol2qm74 7639 13 . . . cord-015021-pol2qm74 7640 1 Especially especially RB cord-015021-pol2qm74 7640 2 baboon baboon NN cord-015021-pol2qm74 7640 3 anti anti NN cord-015021-pol2qm74 7640 4 - - NNP cord-015021-pol2qm74 7640 5 TNFab TNFab NNP cord-015021-pol2qm74 7640 6 studies study NNS cord-015021-pol2qm74 7640 7 provided provide VBD cord-015021-pol2qm74 7640 8 many many JJ cord-015021-pol2qm74 7640 9 insights insight NNS cord-015021-pol2qm74 7640 10 into into IN cord-015021-pol2qm74 7640 11 the the DT cord-015021-pol2qm74 7640 12 pathophysiological pathophysiological JJ cord-015021-pol2qm74 7640 13 sequences sequence NNS cord-015021-pol2qm74 7640 14 of of IN cord-015021-pol2qm74 7640 15 sepsis sepsis NN cord-015021-pol2qm74 7640 16 induction induction NN cord-015021-pol2qm74 7640 17 , , , cord-015021-pol2qm74 7640 18 due due IN cord-015021-pol2qm74 7640 19 to to IN cord-015021-pol2qm74 7640 20 crossreactivity crossreactivity NN cord-015021-pol2qm74 7640 21 with with IN cord-015021-pol2qm74 7640 22 human human JJ cord-015021-pol2qm74 7640 23 reagents reagent NNS cord-015021-pol2qm74 7640 24 . . . cord-015021-pol2qm74 7641 1 Those those DT cord-015021-pol2qm74 7641 2 events event NNS cord-015021-pol2qm74 7641 3 include include VBP cord-015021-pol2qm74 7641 4 the the DT cord-015021-pol2qm74 7641 5 cytokine cytokine NN cord-015021-pol2qm74 7641 6 sequence sequence NN cord-015021-pol2qm74 7641 7 with with IN cord-015021-pol2qm74 7641 8 TNF TNF NNP cord-015021-pol2qm74 7641 9 - - HYPH cord-015021-pol2qm74 7641 10 dependent dependent JJ cord-015021-pol2qm74 7641 11 IL IL NNP cord-015021-pol2qm74 7641 12 - - : cord-015021-pol2qm74 7641 13 I I NNP cord-015021-pol2qm74 7641 14 , , , cord-015021-pol2qm74 7641 15 IL-6 IL-6 NNP cord-015021-pol2qm74 7641 16 , , , cord-015021-pol2qm74 7641 17 or or CC cord-015021-pol2qm74 7641 18 IL-8 IL-8 NNP cord-015021-pol2qm74 7641 19 , , , cord-015021-pol2qm74 7641 20 but but CC cord-015021-pol2qm74 7641 21 also also RB cord-015021-pol2qm74 7641 22 IL IL NNP cord-015021-pol2qm74 7641 23 - - HYPH cord-015021-pol2qm74 7641 24 lra lra NNP cord-015021-pol2qm74 7641 25 or or CC cord-015021-pol2qm74 7641 26 sTNF sTNF NNP cord-015021-pol2qm74 7641 27 receptor receptor NN cord-015021-pol2qm74 7641 28 release release NN cord-015021-pol2qm74 7641 29 . . . cord-015021-pol2qm74 7642 1 Granulocyte Granulocyte NNP cord-015021-pol2qm74 7642 2 as as RB cord-015021-pol2qm74 7642 3 well well RB cord-015021-pol2qm74 7642 4 as as IN cord-015021-pol2qm74 7642 5 endothelial endothelial JJ cord-015021-pol2qm74 7642 6 cell cell NN cord-015021-pol2qm74 7642 7 activation activation NN cord-015021-pol2qm74 7642 8 were be VBD cord-015021-pol2qm74 7642 9 shown show VBN cord-015021-pol2qm74 7642 10 to to TO cord-015021-pol2qm74 7642 11 be be VB cord-015021-pol2qm74 7642 12 partly partly RB cord-015021-pol2qm74 7642 13 TNF TNF NNP cord-015021-pol2qm74 7642 14 related relate VBN cord-015021-pol2qm74 7642 15 , , , cord-015021-pol2qm74 7642 16 and and CC cord-015021-pol2qm74 7642 17 the the DT cord-015021-pol2qm74 7642 18 procoagulatory procoagulatory NNP cord-015021-pol2qm74 7642 19 response response NN cord-015021-pol2qm74 7642 20 was be VBD cord-015021-pol2qm74 7642 21 influenced influence VBN cord-015021-pol2qm74 7642 22 by by IN cord-015021-pol2qm74 7642 23 anti anti JJ cord-015021-pol2qm74 7642 24 - - JJ cord-015021-pol2qm74 7642 25 TNF TNF NNP cord-015021-pol2qm74 7642 26 treatment treatment NN cord-015021-pol2qm74 7642 27 . . . cord-015021-pol2qm74 7643 1 From from IN cord-015021-pol2qm74 7643 2 many many JJ cord-015021-pol2qm74 7643 3 animal animal NN cord-015021-pol2qm74 7643 4 studies study NNS cord-015021-pol2qm74 7643 5 the the DT cord-015021-pol2qm74 7643 6 concept concept NN cord-015021-pol2qm74 7643 7 that that WDT cord-015021-pol2qm74 7643 8 TNF TNF NNP cord-015021-pol2qm74 7643 9 plays play VBZ cord-015021-pol2qm74 7643 10 a a DT cord-015021-pol2qm74 7643 11 pivotal pivotal JJ cord-015021-pol2qm74 7643 12 role role NN cord-015021-pol2qm74 7643 13 in in IN cord-015021-pol2qm74 7643 14 sepsis sepsis NN cord-015021-pol2qm74 7643 15 is be VBZ cord-015021-pol2qm74 7643 16 clearly clearly RB cord-015021-pol2qm74 7643 17 evident evident JJ cord-015021-pol2qm74 7643 18 and and CC cord-015021-pol2qm74 7643 19 therefore therefore RB cord-015021-pol2qm74 7643 20 anti anti JJ cord-015021-pol2qm74 7643 21 - - JJ cord-015021-pol2qm74 7643 22 TNF TNF NNP cord-015021-pol2qm74 7643 23 therapy therapy NN cord-015021-pol2qm74 7643 24 is be VBZ cord-015021-pol2qm74 7643 25 a a DT cord-015021-pol2qm74 7643 26 major major JJ cord-015021-pol2qm74 7643 27 candidate candidate NN cord-015021-pol2qm74 7643 28 tbr tbr NNP cord-015021-pol2qm74 7643 29 clinical clinical JJ cord-015021-pol2qm74 7643 30 studies study NNS cord-015021-pol2qm74 7643 31 . . . cord-015021-pol2qm74 7644 1 The the DT cord-015021-pol2qm74 7644 2 beneficial beneficial JJ cord-015021-pol2qm74 7644 3 or or CC cord-015021-pol2qm74 7644 4 harmful harmful JJ cord-015021-pol2qm74 7644 5 effects effect NNS cord-015021-pol2qm74 7644 6 of of IN cord-015021-pol2qm74 7644 7 TNF tnf NN cord-015021-pol2qm74 7644 8 - - HYPH cord-015021-pol2qm74 7644 9 mediated mediate VBN cord-015021-pol2qm74 7644 10 inflammatory inflammatory JJ cord-015021-pol2qm74 7644 11 responses response NNS cord-015021-pol2qm74 7644 12 depend depend VBP cord-015021-pol2qm74 7644 13 on on IN cord-015021-pol2qm74 7644 14 the the DT cord-015021-pol2qm74 7644 15 clinical clinical JJ cord-015021-pol2qm74 7644 16 context context NN cord-015021-pol2qm74 7644 17 . . . cord-015021-pol2qm74 7645 1 Decreasing decrease VBG cord-015021-pol2qm74 7645 2 exaggerated exaggerated JJ cord-015021-pol2qm74 7645 3 TNF tnf NN cord-015021-pol2qm74 7645 4 - - HYPH cord-015021-pol2qm74 7645 5 mediated mediate VBN cord-015021-pol2qm74 7645 6 inflammatory inflammatory JJ cord-015021-pol2qm74 7645 7 responses response NNS cord-015021-pol2qm74 7645 8 may may MD cord-015021-pol2qm74 7645 9 be be VB cord-015021-pol2qm74 7645 10 useful useful JJ cord-015021-pol2qm74 7645 11 in in IN cord-015021-pol2qm74 7645 12 some some DT cord-015021-pol2qm74 7645 13 patients patient NNS cord-015021-pol2qm74 7645 14 with with IN cord-015021-pol2qm74 7645 15 organ organ NN cord-015021-pol2qm74 7645 16 failure failure NN cord-015021-pol2qm74 7645 17 . . . cord-015021-pol2qm74 7646 1 TNFR TNFR NNP cord-015021-pol2qm74 7646 2 : : : cord-015021-pol2qm74 7647 1 Fc Fc NNP cord-015021-pol2qm74 7647 2 ( ( -LRB- cord-015021-pol2qm74 7647 3 Immunex Immunex NNP cord-015021-pol2qm74 7647 4 , , , cord-015021-pol2qm74 7647 5 Seattle Seattle NNP cord-015021-pol2qm74 7647 6 , , , cord-015021-pol2qm74 7647 7 WA WA NNP cord-015021-pol2qm74 7647 8 ) ) -RRB- cord-015021-pol2qm74 7647 9 is be VBZ cord-015021-pol2qm74 7647 10 a a DT cord-015021-pol2qm74 7647 11 recombinant recombinant JJ cord-015021-pol2qm74 7647 12 human human JJ cord-015021-pol2qm74 7647 13 protein protein NN cord-015021-pol2qm74 7647 14 composed compose VBN cord-015021-pol2qm74 7647 15 of of IN cord-015021-pol2qm74 7647 16 two two CD cord-015021-pol2qm74 7647 17 identical identical JJ cord-015021-pol2qm74 7647 18 extracellular extracellular JJ cord-015021-pol2qm74 7647 19 p80 p80 NN cord-015021-pol2qm74 7647 20 TNF TNF NNP cord-015021-pol2qm74 7647 21 receptors receptor NNS cord-015021-pol2qm74 7647 22 linked link VBN cord-015021-pol2qm74 7647 23 by by IN cord-015021-pol2qm74 7647 24 the the DT cord-015021-pol2qm74 7647 25 Fc Fc NNP cord-015021-pol2qm74 7647 26 region region NN cord-015021-pol2qm74 7647 27 of of IN cord-015021-pol2qm74 7647 28 IgGl IgGl NNP cord-015021-pol2qm74 7647 29 . . . cord-015021-pol2qm74 7648 1 It -PRON- PRP cord-015021-pol2qm74 7648 2 neutralizes neutralize VBZ cord-015021-pol2qm74 7648 3 TNF TNF NNP cord-015021-pol2qm74 7648 4 with with IN cord-015021-pol2qm74 7648 5 an an DT cord-015021-pol2qm74 7648 6 affinity affinity NN cord-015021-pol2qm74 7648 7 for for IN cord-015021-pol2qm74 7648 8 TNF TNF NNP cord-015021-pol2qm74 7648 9 < < XX cord-015021-pol2qm74 7648 10 z z NNP cord-015021-pol2qm74 7648 11 of of IN cord-015021-pol2qm74 7648 12 10 10 CD cord-015021-pol2qm74 7648 13 - - SYM cord-015021-pol2qm74 7648 14 10 10 CD cord-015021-pol2qm74 7648 15 M M NNP cord-015021-pol2qm74 7648 16 and and CC cord-015021-pol2qm74 7648 17 has have VBZ cord-015021-pol2qm74 7648 18 a a DT cord-015021-pol2qm74 7648 19 T1/2 t1/2 NN cord-015021-pol2qm74 7648 20 of of IN cord-015021-pol2qm74 7648 21 • • NNP cord-015021-pol2qm74 7648 22 63h 63h CD cord-015021-pol2qm74 7648 23 in in IN cord-015021-pol2qm74 7648 24 normal normal JJ cord-015021-pol2qm74 7648 25 humans human NNS cord-015021-pol2qm74 7648 26 . . . cord-015021-pol2qm74 7649 1 Methods method NNS cord-015021-pol2qm74 7649 2 : : : cord-015021-pol2qm74 7649 3 18 18 CD cord-015021-pol2qm74 7649 4 normal normal JJ cord-015021-pol2qm74 7649 5 volunteers volunteer NNS cord-015021-pol2qm74 7649 6 were be VBD cord-015021-pol2qm74 7649 7 randomized randomize VBN cord-015021-pol2qm74 7649 8 to to TO cord-015021-pol2qm74 7649 9 receive receive VB cord-015021-pol2qm74 7649 10 either either DT cord-015021-pol2qm74 7649 11 TNFR TNFR NNP cord-015021-pol2qm74 7649 12 : : : cord-015021-pol2qm74 7650 1 Fc Fc NNP cord-015021-pol2qm74 7650 2 vehicle vehicle NN cord-015021-pol2qm74 7650 3 ( ( -LRB- cord-015021-pol2qm74 7650 4 n=6 n=6 NNP cord-015021-pol2qm74 7650 5 ) ) -RRB- cord-015021-pol2qm74 7650 6 , , , cord-015021-pol2qm74 7650 7 or or CC cord-015021-pol2qm74 7650 8 low low JJ cord-015021-pol2qm74 7650 9 dose dose NN cord-015021-pol2qm74 7650 10 ( ( -LRB- cord-015021-pol2qm74 7650 11 LD LD NNP cord-015021-pol2qm74 7650 12 ) ) -RRB- cord-015021-pol2qm74 7650 13 TNFR TNFR NNP cord-015021-pol2qm74 7650 14 : : : cord-015021-pol2qm74 7650 15 Fc Fc NNP cord-015021-pol2qm74 7650 16 ( ( -LRB- cord-015021-pol2qm74 7650 17 10 10 CD cord-015021-pol2qm74 7650 18 mg mg NNP cord-015021-pol2qm74 7650 19 / / SYM cord-015021-pol2qm74 7650 20 m m NNP cord-015021-pol2qm74 7650 21 2 2 CD cord-015021-pol2qm74 7650 22 iv iv CD cord-015021-pol2qm74 7650 23 , , , cord-015021-pol2qm74 7650 24 n=6 n=6 NNP cord-015021-pol2qm74 7650 25 ) ) -RRB- cord-015021-pol2qm74 7650 26 , , , cord-015021-pol2qm74 7650 27 or or CC cord-015021-pol2qm74 7650 28 high high JJ cord-015021-pol2qm74 7650 29 dose dose NN cord-015021-pol2qm74 7650 30 ( ( -LRB- cord-015021-pol2qm74 7650 31 HD HD NNP cord-015021-pol2qm74 7650 32 ) ) -RRB- cord-015021-pol2qm74 7650 33 TNFR TNFR NNP cord-015021-pol2qm74 7650 34 : : : cord-015021-pol2qm74 7651 1 Fc Fc NNP cord-015021-pol2qm74 7651 2 ( ( -LRB- cord-015021-pol2qm74 7651 3 60 60 CD cord-015021-pol2qm74 7651 4 mg mg NNP cord-015021-pol2qm74 7651 5 / / SYM cord-015021-pol2qm74 7651 6 m m NN cord-015021-pol2qm74 7651 7 2 2 CD cord-015021-pol2qm74 7652 1 iv iv LS cord-015021-pol2qm74 7652 2 , , , cord-015021-pol2qm74 7652 3 n=6 n=6 NNP cord-015021-pol2qm74 7652 4 ) ) -RRB- cord-015021-pol2qm74 7652 5 infused infuse VBN cord-015021-pol2qm74 7652 6 over over IN cord-015021-pol2qm74 7652 7 30 30 CD cord-015021-pol2qm74 7652 8 rain rain NN cord-015021-pol2qm74 7652 9 prior prior RB cord-015021-pol2qm74 7652 10 to to IN cord-015021-pol2qm74 7652 11 endotoxin endotoxin NN cord-015021-pol2qm74 7652 12 ( ( -LRB- cord-015021-pol2qm74 7652 13 E e NN cord-015021-pol2qm74 7652 14 ) ) -RRB- cord-015021-pol2qm74 7653 1 ( ( -LRB- cord-015021-pol2qm74 7653 2 Escherichia Escherichia NNP cord-015021-pol2qm74 7653 3 coil coil NN cord-015021-pol2qm74 7653 4 0:113 0:113 CD cord-015021-pol2qm74 7653 5 ; ; : cord-015021-pol2qm74 7653 6 4 4 CD cord-015021-pol2qm74 7653 7 ng ng NNP cord-015021-pol2qm74 7653 8 / / SYM cord-015021-pol2qm74 7653 9 kg kg NNP cord-015021-pol2qm74 7653 10 iv iv NNP cord-015021-pol2qm74 7653 11 ) ) -RRB- cord-015021-pol2qm74 7653 12 administration administration NN cord-015021-pol2qm74 7653 13 . . . cord-015021-pol2qm74 7654 1 Plasma plasma NN cord-015021-pol2qm74 7654 2 cytokines cytokine NNS cord-015021-pol2qm74 7654 3 were be VBD cord-015021-pol2qm74 7654 4 measured measure VBN cord-015021-pol2qm74 7654 5 using use VBG cord-015021-pol2qm74 7654 6 ELISA ELISA NNP cord-015021-pol2qm74 7654 7 and and CC cord-015021-pol2qm74 7654 8 TNF TNF NNP cord-015021-pol2qm74 7654 9 bioactiv'dy bioactiv'dy NNP cord-015021-pol2qm74 7654 10 . . . cord-015021-pol2qm74 7655 1 Systemic systemic JJ cord-015021-pol2qm74 7655 2 hemodynamics hemodynamic NNS cord-015021-pol2qm74 7655 3 were be VBD cord-015021-pol2qm74 7655 4 evaluated evaluate VBN cord-015021-pol2qm74 7655 5 with with IN cord-015021-pol2qm74 7655 6 indwelling indwell VBG cord-015021-pol2qm74 7655 7 arterial arterial JJ cord-015021-pol2qm74 7655 8 and and CC cord-015021-pol2qm74 7655 9 pulmonary pulmonary JJ cord-015021-pol2qm74 7655 10 artery artery NN cord-015021-pol2qm74 7655 11 catheters catheter NNS cord-015021-pol2qm74 7655 12 and and CC cord-015021-pol2qm74 7655 13 radionuclide radionuclide NN cord-015021-pol2qm74 7655 14 heart heart NN cord-015021-pol2qm74 7655 15 scans scan NNS cord-015021-pol2qm74 7655 16 and and CC cord-015021-pol2qm74 7655 17 compared compare VBN cord-015021-pol2qm74 7655 18 before before RB cord-015021-pol2qm74 7655 19 and and CC cord-015021-pol2qm74 7655 20 after after IN cord-015021-pol2qm74 7655 21 fluid fluid JJ cord-015021-pol2qm74 7655 22 loading loading NN cord-015021-pol2qm74 7655 23 in in IN cord-015021-pol2qm74 7655 24 subjects subject NNS cord-015021-pol2qm74 7655 25 given give VBN cord-015021-pol2qm74 7655 26 vehicle vehicle NN cord-015021-pol2qm74 7655 27 with with IN cord-015021-pol2qm74 7655 28 HD HD NNP cord-015021-pol2qm74 7655 29 TNFR TNFR NNP cord-015021-pol2qm74 7655 30 : : : cord-015021-pol2qm74 7656 1 Fc Fc NNP cord-015021-pol2qm74 7656 2 . . . cord-015021-pol2qm74 7657 1 Results result NNS cord-015021-pol2qm74 7657 2 : : : cord-015021-pol2qm74 7658 1 Endotoxin endotoxin NN cord-015021-pol2qm74 7658 2 - - HYPH cord-015021-pol2qm74 7658 3 related relate VBN cord-015021-pol2qm74 7658 4 symptoms symptom NNS cord-015021-pol2qm74 7658 5 were be VBD cord-015021-pol2qm74 7658 6 unchanged unchanged JJ cord-015021-pol2qm74 7658 7 after after IN cord-015021-pol2qm74 7658 8 LD LD NNP cord-015021-pol2qm74 7658 9 or or CC cord-015021-pol2qm74 7658 10 HD HD NNP cord-015021-pol2qm74 7658 11 . . . cord-015021-pol2qm74 7659 1 Peak peak NN cord-015021-pol2qm74 7659 2 temperature temperature NN cord-015021-pol2qm74 7659 3 occurred occur VBD cord-015021-pol2qm74 7659 4 at at IN cord-015021-pol2qm74 7659 5 a a DT cord-015021-pol2qm74 7659 6 later later JJ cord-015021-pol2qm74 7659 7 time time NN cord-015021-pol2qm74 7659 8 point point NN cord-015021-pol2qm74 7659 9 ( ( -LRB- cord-015021-pol2qm74 7659 10 4 4 CD cord-015021-pol2qm74 7659 11 - - SYM cord-015021-pol2qm74 7659 12 5h 5h CD cord-015021-pol2qm74 7659 13 ) ) -RRB- cord-015021-pol2qm74 7659 14 in in IN cord-015021-pol2qm74 7659 15 subjects subject NNS cord-015021-pol2qm74 7659 16 given give VBN cord-015021-pol2qm74 7659 17 TNFR TNFR NNP cord-015021-pol2qm74 7659 18 : : : cord-015021-pol2qm74 7660 1 Fc Fc NNP cord-015021-pol2qm74 7660 2 compared compare VBN cord-015021-pol2qm74 7660 3 to to IN cord-015021-pol2qm74 7660 4 vehicle vehicle NN cord-015021-pol2qm74 7660 5 ( ( -LRB- cord-015021-pol2qm74 7660 6 3h 3h CD cord-015021-pol2qm74 7660 7 ) ) -RRB- cord-015021-pol2qm74 7660 8 ( ( -LRB- cord-015021-pol2qm74 7660 9 p=.004 p=.004 NNP cord-015021-pol2qm74 7660 10 ) ) -RRB- cord-015021-pol2qm74 7660 11 . . . cord-015021-pol2qm74 7661 1 At at IN cord-015021-pol2qm74 7661 2 3h 3h CD cord-015021-pol2qm74 7661 3 , , , cord-015021-pol2qm74 7661 4 5h 5h NNP cord-015021-pol2qm74 7661 5 ( ( -LRB- cord-015021-pol2qm74 7661 6 post post JJ cord-015021-pol2qm74 7661 7 fluid fluid JJ cord-015021-pol2qm74 7661 8 load load NN cord-015021-pol2qm74 7661 9 ) ) -RRB- cord-015021-pol2qm74 7661 10 , , , cord-015021-pol2qm74 7661 11 and and CC cord-015021-pol2qm74 7661 12 8h 8h NNP cord-015021-pol2qm74 7661 13 , , , cord-015021-pol2qm74 7661 14 subjects subject NNS cord-015021-pol2qm74 7661 15 given give VBN cord-015021-pol2qm74 7661 16 vehicle vehicle NN cord-015021-pol2qm74 7661 17 developed develop VBD cord-015021-pol2qm74 7661 18 increased increase VBN cord-015021-pol2qm74 7661 19 cardiac cardiac JJ cord-015021-pol2qm74 7661 20 index index NN cord-015021-pol2qm74 7661 21 and and CC cord-015021-pol2qm74 7661 22 heart heart NN cord-015021-pol2qm74 7661 23 rate rate NN cord-015021-pol2qm74 7661 24 and and CC cord-015021-pol2qm74 7661 25 decreased decrease VBD cord-015021-pol2qm74 7661 26 systemic systemic JJ cord-015021-pol2qm74 7661 27 vascular vascular JJ cord-015021-pol2qm74 7661 28 resistance resistance NN cord-015021-pol2qm74 7661 29 index index NN cord-015021-pol2qm74 7661 30 ( ( -LRB- cord-015021-pol2qm74 7661 31 all all DT cord-015021-pol2qm74 7661 32 p=.0001 p=.0001 JJ cord-015021-pol2qm74 7661 33 ) ) -RRB- cord-015021-pol2qm74 7661 34 . . . cord-015021-pol2qm74 7662 1 HD HD NNP cord-015021-pol2qm74 7662 2 TNFR TNFR NNP cord-015021-pol2qm74 7662 3 : : : cord-015021-pol2qm74 7663 1 Fc Fc NNP cord-015021-pol2qm74 7663 2 did do VBD cord-015021-pol2qm74 7663 3 not not RB cord-015021-pol2qm74 7663 4 alter alter VB cord-015021-pol2qm74 7663 5 this this DT cord-015021-pol2qm74 7663 6 hyperdynamic hyperdynamic JJ cord-015021-pol2qm74 7663 7 cardiovascular cardiovascular JJ cord-015021-pol2qm74 7663 8 response response NN cord-015021-pol2qm74 7663 9 . . . cord-015021-pol2qm74 7664 1 LD LD NNP cord-015021-pol2qm74 7664 2 and and CC cord-015021-pol2qm74 7664 3 HD HD NNP cord-015021-pol2qm74 7664 4 inhibited inhibit VBD cord-015021-pol2qm74 7664 5 the the DT cord-015021-pol2qm74 7664 6 E e NN cord-015021-pol2qm74 7664 7 - - HYPH cord-015021-pol2qm74 7664 8 induced induce VBN cord-015021-pol2qm74 7664 9 teukopenta teukopenta NN cord-015021-pol2qm74 7664 10 at at IN cord-015021-pol2qm74 7664 11 I -PRON- PRP cord-015021-pol2qm74 7665 1 h h NNP cord-015021-pol2qm74 7665 2 post post NN cord-015021-pol2qm74 7665 3 endotoxin endotoxin NN cord-015021-pol2qm74 7665 4 ( ( -LRB- cord-015021-pol2qm74 7665 5 p<.03 p<.03 NNP cord-015021-pol2qm74 7665 6 ) ) -RRB- cord-015021-pol2qm74 7665 7 and and CC cord-015021-pol2qm74 7665 8 later later RB cord-015021-pol2qm74 7665 9 leukocytosis leukocytosis NNP cord-015021-pol2qm74 7665 10 ( ( -LRB- cord-015021-pol2qm74 7665 11 p<0.05 p<0.05 NNP cord-015021-pol2qm74 7665 12 ) ) -RRB- cord-015021-pol2qm74 7665 13 . . . cord-015021-pol2qm74 7666 1 Peak Peak NNP cord-015021-pol2qm74 7666 2 TNF TNF NNP cord-015021-pol2qm74 7666 3 bioactivity bioactivity NN cord-015021-pol2qm74 7666 4 in in IN cord-015021-pol2qm74 7666 5 subjects subject NNS cord-015021-pol2qm74 7666 6 given give VBN cord-015021-pol2qm74 7666 7 vehicle vehicle NN cord-015021-pol2qm74 7666 8 was be VBD cord-015021-pol2qm74 7666 9 154 154 CD cord-015021-pol2qm74 7666 10 + + SYM cord-015021-pol2qm74 7666 11 44 44 CD cord-015021-pol2qm74 7666 12 pg pg NN cord-015021-pol2qm74 7666 13 / / SYM cord-015021-pol2qm74 7666 14 mL ml NN cord-015021-pol2qm74 7666 15 and and CC cord-015021-pol2qm74 7666 16 < < XX cord-015021-pol2qm74 7666 17 10 10 CD cord-015021-pol2qm74 7666 18 pg pg NN cord-015021-pol2qm74 7666 19 / / SYM cord-015021-pol2qm74 7666 20 mL ml NN cord-015021-pol2qm74 7666 21 in in IN cord-015021-pol2qm74 7666 22 the the DT cord-015021-pol2qm74 7666 23 LD LD NNP cord-015021-pol2qm74 7666 24 or or CC cord-015021-pol2qm74 7666 25 HD HD NNP cord-015021-pol2qm74 7666 26 TNFR TNFR NNP cord-015021-pol2qm74 7666 27 : : : cord-015021-pol2qm74 7667 1 Fc Fc NNP cord-015021-pol2qm74 7667 2 groups group NNS cord-015021-pol2qm74 7667 3 ( ( -LRB- cord-015021-pol2qm74 7667 4 p<.001 p<.001 NNP cord-015021-pol2qm74 7667 5 ) ) -RRB- cord-015021-pol2qm74 7667 6 . . . cord-015021-pol2qm74 7668 1 Two two CD cord-015021-pol2qm74 7668 2 immunoassays immunoassay NNS cord-015021-pol2qm74 7668 3 for for IN cord-015021-pol2qm74 7668 4 TNF TNF NNP cord-015021-pol2qm74 7668 5 were be VBD cord-015021-pol2qm74 7668 6 performed perform VBN cord-015021-pol2qm74 7668 7 because because IN cord-015021-pol2qm74 7668 8 the the DT cord-015021-pol2qm74 7668 9 detection detection NN cord-015021-pol2qm74 7668 10 of of IN cord-015021-pol2qm74 7668 11 receptor receptor NN cord-015021-pol2qm74 7668 12 bound bind VBN cord-015021-pol2qm74 7668 13 TNF TNF NNP cord-015021-pol2qm74 7668 14 varies vary VBZ cord-015021-pol2qm74 7668 15 with with IN cord-015021-pol2qm74 7668 16 ELISA ELISA NNP cord-015021-pol2qm74 7668 17 . . . cord-015021-pol2qm74 7669 1 TNF TNF NNP cord-015021-pol2qm74 7669 2 ( ( -LRB- cord-015021-pol2qm74 7669 3 Biosource Biosource NNP cord-015021-pol2qm74 7669 4 ) ) -RRB- cord-015021-pol2qm74 7669 5 was be VBD cord-015021-pol2qm74 7669 6 decreased decrease VBN cord-015021-pol2qm74 7669 7 in in IN cord-015021-pol2qm74 7669 8 LD LD NNP cord-015021-pol2qm74 7669 9 vs vs IN cord-015021-pol2qm74 7669 10 vehicle vehicle NN cord-015021-pol2qm74 7669 11 or or CC cord-015021-pol2qm74 7669 12 HD hd NN cord-015021-pol2qm74 7669 13 ( ( -LRB- cord-015021-pol2qm74 7669 14 p=.0001 p=.0001 NNP cord-015021-pol2qm74 7669 15 ) ) -RRB- cord-015021-pol2qm74 7669 16 whereas whereas IN cord-015021-pol2qm74 7669 17 TNF TNF NNP cord-015021-pol2qm74 7669 18 ( ( -LRB- cord-015021-pol2qm74 7669 19 R&D R&D NNP cord-015021-pol2qm74 7669 20 Systems Systems NNPS cord-015021-pol2qm74 7669 21 ) ) -RRB- cord-015021-pol2qm74 7669 22 was be VBD cord-015021-pol2qm74 7669 23 increased increase VBN cord-015021-pol2qm74 7669 24 after after IN cord-015021-pol2qm74 7669 25 HD hd NN cord-015021-pol2qm74 7669 26 or or CC cord-015021-pol2qm74 7669 27 LD LD NNP cord-015021-pol2qm74 7669 28 vs vs IN cord-015021-pol2qm74 7669 29 vehicle vehicle NN cord-015021-pol2qm74 7669 30 ( ( -LRB- cord-015021-pol2qm74 7669 31 p<.001 p<.001 NNP cord-015021-pol2qm74 7669 32 ) ) -RRB- cord-015021-pol2qm74 7669 33 . . . cord-015021-pol2qm74 7670 1 Decreased decrease VBN cord-015021-pol2qm74 7670 2 levels level NNS cord-015021-pol2qm74 7670 3 of of IN cord-015021-pol2qm74 7670 4 IL-8 IL-8 NNP cord-015021-pol2qm74 7670 5 ( ( -LRB- cord-015021-pol2qm74 7670 6 p=.00 p=.00 CD cord-015021-pol2qm74 7670 7 t t NN cord-015021-pol2qm74 7670 8 ) ) -RRB- cord-015021-pol2qm74 7670 9 , , , cord-015021-pol2qm74 7670 10 granulocyte granulocyte NN cord-015021-pol2qm74 7670 11 colony colony NN cord-015021-pol2qm74 7670 12 stimulating stimulate VBG cord-015021-pol2qm74 7670 13 factor factor NN cord-015021-pol2qm74 7670 14 ( ( -LRB- cord-015021-pol2qm74 7670 15 p=.03 p=.03 NN cord-015021-pol2qm74 7670 16 ) ) -RRB- cord-015021-pol2qm74 7670 17 , , , cord-015021-pol2qm74 7670 18 and and CC cord-015021-pol2qm74 7670 19 IL-1 IL-1 NNP cord-015021-pol2qm74 7670 20 receptor receptor NN cord-015021-pol2qm74 7670 21 antagonist antagonist NN cord-015021-pol2qm74 7670 22 ( ( -LRB- cord-015021-pol2qm74 7670 23 p=.001 p=.001 NNP cord-015021-pol2qm74 7670 24 ) ) -RRB- cord-015021-pol2qm74 7670 25 were be VBD cord-015021-pol2qm74 7670 26 found find VBN cord-015021-pol2qm74 7670 27 after after IN cord-015021-pol2qm74 7670 28 LD LD NNP cord-015021-pol2qm74 7670 29 or or CC cord-015021-pol2qm74 7670 30 HD HD NNP cord-015021-pol2qm74 7670 31 vs vs IN cord-015021-pol2qm74 7670 32 vehicle vehicle NN cord-015021-pol2qm74 7670 33 . . . cord-015021-pol2qm74 7671 1 IL-6 IL-6 NNP cord-015021-pol2qm74 7671 2 levels level NNS cord-015021-pol2qm74 7671 3 were be VBD cord-015021-pol2qm74 7671 4 lower low JJR cord-015021-pol2qm74 7671 5 after after IN cord-015021-pol2qm74 7671 6 LD LD NNP cord-015021-pol2qm74 7671 7 vs vs IN cord-015021-pol2qm74 7671 8 vehicle vehicle NN cord-015021-pol2qm74 7671 9 or or CC cord-015021-pol2qm74 7671 10 HD hd NN cord-015021-pol2qm74 7671 11 ( ( -LRB- cord-015021-pol2qm74 7671 12 p=.006 p=.006 NNP cord-015021-pol2qm74 7671 13 ) ) -RRB- cord-015021-pol2qm74 7671 14 . . . cord-015021-pol2qm74 7672 1 IL-10 IL-10 NNP cord-015021-pol2qm74 7672 2 levels level NNS cord-015021-pol2qm74 7672 3 were be VBD cord-015021-pol2qm74 7672 4 similar similar JJ cord-015021-pol2qm74 7672 5 among among IN cord-015021-pol2qm74 7672 6 subjects subject NNS cord-015021-pol2qm74 7672 7 given give VBN cord-015021-pol2qm74 7672 8 vehicle vehicle NN cord-015021-pol2qm74 7672 9 , , , cord-015021-pol2qm74 7672 10 LD LD NNP cord-015021-pol2qm74 7672 11 , , , cord-015021-pol2qm74 7672 12 and and CC cord-015021-pol2qm74 7672 13 HD HD NNP cord-015021-pol2qm74 7672 14 TNFR TNFR NNP cord-015021-pol2qm74 7672 15 : : : cord-015021-pol2qm74 7673 1 Fc Fc NNP cord-015021-pol2qm74 7673 2 . . . cord-015021-pol2qm74 7674 1 Conclusions conclusion NNS cord-015021-pol2qm74 7674 2 : : : cord-015021-pol2qm74 7675 1 LD LD NNP cord-015021-pol2qm74 7675 2 and and CC cord-015021-pol2qm74 7675 3 HD HD NNP cord-015021-pol2qm74 7675 4 TNFR TNFR NNP cord-015021-pol2qm74 7675 5 : : : cord-015021-pol2qm74 7676 1 Fc Fc NNP cord-015021-pol2qm74 7676 2 delayed delay VBD cord-015021-pol2qm74 7676 3 the the DT cord-015021-pol2qm74 7676 4 febrile febrile JJ cord-015021-pol2qm74 7676 5 response response NN cord-015021-pol2qm74 7676 6 to to IN cord-015021-pol2qm74 7676 7 E e NN cord-015021-pol2qm74 7676 8 but but CC cord-015021-pol2qm74 7676 9 did do VBD cord-015021-pol2qm74 7676 10 not not RB cord-015021-pol2qm74 7676 11 alter alter VB cord-015021-pol2qm74 7676 12 the the DT cord-015021-pol2qm74 7676 13 early early JJ cord-015021-pol2qm74 7676 14 hyperdynamic hyperdynamic JJ cord-015021-pol2qm74 7676 15 cardiac cardiac JJ cord-015021-pol2qm74 7676 16 response response NN cord-015021-pol2qm74 7676 17 . . . cord-015021-pol2qm74 7677 1 This this DT cord-015021-pol2qm74 7677 2 suggests suggest VBZ cord-015021-pol2qm74 7677 3 that that IN cord-015021-pol2qm74 7677 4 mediators mediator NNS cord-015021-pol2qm74 7677 5 other other JJ cord-015021-pol2qm74 7677 6 than than IN cord-015021-pol2qm74 7677 7 TNF TNF NNP cord-015021-pol2qm74 7677 8 play play VBP cord-015021-pol2qm74 7677 9 an an DT cord-015021-pol2qm74 7677 10 important important JJ cord-015021-pol2qm74 7677 11 role role NN cord-015021-pol2qm74 7677 12 in in IN cord-015021-pol2qm74 7677 13 the the DT cord-015021-pol2qm74 7677 14 initial initial JJ cord-015021-pol2qm74 7677 15 cardiovascular cardiovascular JJ cord-015021-pol2qm74 7677 16 response response NN cord-015021-pol2qm74 7677 17 to to IN cord-015021-pol2qm74 7677 18 E e NN cord-015021-pol2qm74 7677 19 in in IN cord-015021-pol2qm74 7677 20 humans human NNS cord-015021-pol2qm74 7677 21 . . . cord-015021-pol2qm74 7678 1 TNFR TNFR NNP cord-015021-pol2qm74 7678 2 : : : cord-015021-pol2qm74 7679 1 Fc Fc NNP cord-015021-pol2qm74 7679 2 attenuated attenuate VBD cord-015021-pol2qm74 7679 3 the the DT cord-015021-pol2qm74 7679 4 release release NN cord-015021-pol2qm74 7679 5 of of IN cord-015021-pol2qm74 7679 6 some some DT cord-015021-pol2qm74 7679 7 E e NN cord-015021-pol2qm74 7679 8 and and CC cord-015021-pol2qm74 7679 9 TNF tnf NN cord-015021-pol2qm74 7679 10 - - HYPH cord-015021-pol2qm74 7679 11 induced induce VBN cord-015021-pol2qm74 7679 12 cytokines cytokine NNS cord-015021-pol2qm74 7679 13 . . . cord-015021-pol2qm74 7680 1 Ti Ti NNP cord-015021-pol2qm74 7681 1 ~e ~e NFP cord-015021-pol2qm74 7681 2 antiinflammatory antiinflammatory JJ cord-015021-pol2qm74 7681 3 responses response NNS cord-015021-pol2qm74 7681 4 of of IN cord-015021-pol2qm74 7681 5 TNFR TNFR NNP cord-015021-pol2qm74 7681 6 : : : cord-015021-pol2qm74 7682 1 Fc Fc NNP cord-015021-pol2qm74 7682 2 may may MD cord-015021-pol2qm74 7682 3 be be VB cord-015021-pol2qm74 7682 4 useful useful JJ cord-015021-pol2qm74 7682 5 in in IN cord-015021-pol2qm74 7682 6 some some DT cord-015021-pol2qm74 7682 7 patients patient NNS cord-015021-pol2qm74 7682 8 with with IN cord-015021-pol2qm74 7682 9 disease disease NN cord-015021-pol2qm74 7682 10 processes process NNS cord-015021-pol2qm74 7682 11 resulting result VBG cord-015021-pol2qm74 7682 12 from from IN cord-015021-pol2qm74 7682 13 excessive excessive JJ cord-015021-pol2qm74 7682 14 TNF tnf NN cord-015021-pol2qm74 7682 15 - - HYPH cord-015021-pol2qm74 7682 16 mediated mediate VBN cord-015021-pol2qm74 7682 17 inflammatory inflammatory JJ cord-015021-pol2qm74 7682 18 responses response NNS cord-015021-pol2qm74 7682 19 . . . cord-015021-pol2qm74 7683 1 The the DT cord-015021-pol2qm74 7683 2 biosynthesis biosynthesis NN cord-015021-pol2qm74 7683 3 of of IN cord-015021-pol2qm74 7683 4 TNF TNF NNP cord-015021-pol2qm74 7683 5 within within IN cord-015021-pol2qm74 7683 6 macrophages macrophage NNS cord-015021-pol2qm74 7683 7 is be VBZ cord-015021-pol2qm74 7683 8 regulated regulate VBN cord-015021-pol2qm74 7683 9 both both CC cord-015021-pol2qm74 7683 10 at at IN cord-015021-pol2qm74 7683 11 the the DT cord-015021-pol2qm74 7683 12 transcriptional transcriptional NN cord-015021-pol2qm74 7683 13 and and CC cord-015021-pol2qm74 7683 14 the the DT cord-015021-pol2qm74 7683 15 translational translational JJ cord-015021-pol2qm74 7683 16 levels level NNS cord-015021-pol2qm74 7683 17 . . . cord-015021-pol2qm74 7684 1 The the DT cord-015021-pol2qm74 7684 2 5 5 CD cord-015021-pol2qm74 7684 3 ' ' POS cord-015021-pol2qm74 7684 4 flanking flank VBG cord-015021-pol2qm74 7684 5 region region NN cord-015021-pol2qm74 7684 6 of of IN cord-015021-pol2qm74 7684 7 the the DT cord-015021-pol2qm74 7684 8 TNF TNF NNP cord-015021-pol2qm74 7684 9 gene gene NN cord-015021-pol2qm74 7684 10 contains contain VBZ cord-015021-pol2qm74 7684 11 several several JJ cord-015021-pol2qm74 7684 12 transcriptional transcriptional JJ cord-015021-pol2qm74 7684 13 control control NN cord-015021-pol2qm74 7684 14 elements element NNS cord-015021-pol2qm74 7684 15 , , , cord-015021-pol2qm74 7684 16 including include VBG cord-015021-pol2qm74 7684 17 two two CD cord-015021-pol2qm74 7684 18 KB KB NNP cord-015021-pol2qm74 7684 19 enhancers enhancer NNS cord-015021-pol2qm74 7684 20 similar similar JJ cord-015021-pol2qm74 7684 21 to to IN cord-015021-pol2qm74 7684 22 those those DT cord-015021-pol2qm74 7684 23 of of IN cord-015021-pol2qm74 7684 24 immunoglobulin immunoglobulin NN cord-015021-pol2qm74 7684 25 genes gene NNS cord-015021-pol2qm74 7684 26 and and CC cord-015021-pol2qm74 7684 27 a a DT cord-015021-pol2qm74 7684 28 " " `` cord-015021-pol2qm74 7684 29 Y Y NNP cord-015021-pol2qm74 7684 30 box box NN cord-015021-pol2qm74 7684 31 " " '' cord-015021-pol2qm74 7684 32 similar similar JJ cord-015021-pol2qm74 7684 33 to to IN cord-015021-pol2qm74 7684 34 that that DT cord-015021-pol2qm74 7684 35 of of IN cord-015021-pol2qm74 7684 36 the the DT cord-015021-pol2qm74 7684 37 MHC MHC NNP cord-015021-pol2qm74 7684 38 class class NN cord-015021-pol2qm74 7684 39 II II NNP cord-015021-pol2qm74 7684 40 promoter promoter NN cord-015021-pol2qm74 7684 41 . . . cord-015021-pol2qm74 7685 1 These these DT cord-015021-pol2qm74 7685 2 elements element NNS cord-015021-pol2qm74 7685 3 are be VBP cord-015021-pol2qm74 7685 4 critical critical JJ cord-015021-pol2qm74 7685 5 for for IN cord-015021-pol2qm74 7685 6 the the DT cord-015021-pol2qm74 7685 7 enhancement enhancement NN cord-015021-pol2qm74 7685 8 of of IN cord-015021-pol2qm74 7685 9 transcription transcription NN cord-015021-pol2qm74 7685 10 noted note VBN cord-015021-pol2qm74 7685 11 after after IN cord-015021-pol2qm74 7685 12 stimulation stimulation NN cord-015021-pol2qm74 7685 13 of of IN cord-015021-pol2qm74 7685 14 macrophages macrophage NNS cord-015021-pol2qm74 7685 15 with with IN cord-015021-pol2qm74 7685 16 LPS lp NNS cord-015021-pol2qm74 7685 17 . . . cord-015021-pol2qm74 7686 1 Despite despite IN cord-015021-pol2qm74 7686 2 these these DT cord-015021-pol2qm74 7686 3 and and CC cord-015021-pol2qm74 7686 4 other other JJ cord-015021-pol2qm74 7686 5 elements element NNS cord-015021-pol2qm74 7686 6 , , , cord-015021-pol2qm74 7686 7 transcriptional transcriptional JJ cord-015021-pol2qm74 7686 8 regulation regulation NN cord-015021-pol2qm74 7686 9 alone alone RB cord-015021-pol2qm74 7686 10 accounts account VBZ cord-015021-pol2qm74 7686 11 neither neither CC cord-015021-pol2qm74 7686 12 for for IN cord-015021-pol2qm74 7686 13 the the DT cord-015021-pol2qm74 7686 14 absence absence NN cord-015021-pol2qm74 7686 15 of of IN cord-015021-pol2qm74 7686 16 TNF TNF NNP cord-015021-pol2qm74 7686 17 protein protein NN cord-015021-pol2qm74 7686 18 during during IN cord-015021-pol2qm74 7686 19 normal normal JJ cord-015021-pol2qm74 7686 20 homeostasis homeostasis NN cord-015021-pol2qm74 7686 21 nor nor CC cord-015021-pol2qm74 7686 22 the the DT cord-015021-pol2qm74 7686 23 profound profound JJ cord-015021-pol2qm74 7686 24 increasein increasein JJ cord-015021-pol2qm74 7686 25 TNF TNF NNP cord-015021-pol2qm74 7686 26 production production NN cord-015021-pol2qm74 7686 27 following follow VBG cord-015021-pol2qm74 7686 28 stimulation stimulation NN cord-015021-pol2qm74 7686 29 with with IN cord-015021-pol2qm74 7686 30 LPS LPS NNP cord-015021-pol2qm74 7686 31 or or CC cord-015021-pol2qm74 7686 32 other other JJ cord-015021-pol2qm74 7686 33 secretagogues secretagogue NNS cord-015021-pol2qm74 7686 34 . . . cord-015021-pol2qm74 7687 1 The the DT cord-015021-pol2qm74 7687 2 translation translation NN cord-015021-pol2qm74 7687 3 of of IN cord-015021-pol2qm74 7687 4 TNF TNF NNP cord-015021-pol2qm74 7687 5 mRNA mRNA NNP cord-015021-pol2qm74 7687 6 into into IN cord-015021-pol2qm74 7687 7 protein protein NN cord-015021-pol2qm74 7687 8 is be VBZ cord-015021-pol2qm74 7687 9 also also RB cord-015021-pol2qm74 7687 10 tightly tightly RB cord-015021-pol2qm74 7687 11 regulated regulate VBN cord-015021-pol2qm74 7687 12 via via IN cord-015021-pol2qm74 7687 13 mechanisms mechanism NNS cord-015021-pol2qm74 7687 14 involving involve VBG cord-015021-pol2qm74 7687 15 the the DT cord-015021-pol2qm74 7687 16 octameric octameric JJ cord-015021-pol2qm74 7687 17 " " `` cord-015021-pol2qm74 7687 18 TTATTTAT ttatttat NN cord-015021-pol2qm74 7687 19 " " '' cord-015021-pol2qm74 7687 20 motif motif NN cord-015021-pol2qm74 7687 21 present present JJ cord-015021-pol2qm74 7687 22 in in IN cord-015021-pol2qm74 7687 23 the the DT cord-015021-pol2qm74 7687 24 3'untranslated 3'untranslated CD cord-015021-pol2qm74 7687 25 region region NN cord-015021-pol2qm74 7687 26 of of IN cord-015021-pol2qm74 7687 27 TNF TNF NNP cord-015021-pol2qm74 7687 28 , , , cord-015021-pol2qm74 7687 29 human human JJ cord-015021-pol2qm74 7687 30 inducible inducible JJ cord-015021-pol2qm74 7687 31 NO no DT cord-015021-pol2qm74 7687 32 synthase synthase NN cord-015021-pol2qm74 7687 33 , , , cord-015021-pol2qm74 7687 34 and and CC cord-015021-pol2qm74 7687 35 several several JJ cord-015021-pol2qm74 7687 36 other other JJ cord-015021-pol2qm74 7687 37 cytokine cytokine NN cord-015021-pol2qm74 7687 38 genes gene NNS cord-015021-pol2qm74 7687 39 . . . cord-015021-pol2qm74 7688 1 This this DT cord-015021-pol2qm74 7688 2 region region NN cord-015021-pol2qm74 7688 3 not not RB cord-015021-pol2qm74 7688 4 only only RB cord-015021-pol2qm74 7688 5 destabilizes destabilize VBZ cord-015021-pol2qm74 7688 6 mRNA mrna NN cord-015021-pol2qm74 7688 7 , , , cord-015021-pol2qm74 7688 8 but but CC cord-015021-pol2qm74 7688 9 also also RB cord-015021-pol2qm74 7688 10 confers confer VBZ cord-015021-pol2qm74 7688 11 a a DT cord-015021-pol2qm74 7688 12 translational translational JJ cord-015021-pol2qm74 7688 13 blockade blockade NN cord-015021-pol2qm74 7688 14 so so IN cord-015021-pol2qm74 7688 15 that that IN cord-015021-pol2qm74 7688 16 TNF TNF NNP cord-015021-pol2qm74 7688 17 protein protein NN cord-015021-pol2qm74 7688 18 is be VBZ cord-015021-pol2qm74 7688 19 not not RB cord-015021-pol2qm74 7688 20 normally normally RB cord-015021-pol2qm74 7688 21 synthesized synthesize VBN cord-015021-pol2qm74 7688 22 despite despite IN cord-015021-pol2qm74 7688 23 leaky leaky JJ cord-015021-pol2qm74 7688 24 basal basal NN cord-015021-pol2qm74 7688 25 transcription transcription NN cord-015021-pol2qm74 7688 26 . . . cord-015021-pol2qm74 7689 1 LPS LPS NNP cord-015021-pol2qm74 7689 2 stimulation stimulation NN cord-015021-pol2qm74 7689 3 releases release VBZ cord-015021-pol2qm74 7689 4 translational translational JJ cord-015021-pol2qm74 7689 5 blockade blockade NN cord-015021-pol2qm74 7689 6 and and CC cord-015021-pol2qm74 7689 7 , , , cord-015021-pol2qm74 7689 8 together together RB cord-015021-pol2qm74 7689 9 with with IN cord-015021-pol2qm74 7689 10 enhanced enhance VBN cord-015021-pol2qm74 7689 11 trancriptional trancriptional JJ cord-015021-pol2qm74 7689 12 rate rate NN cord-015021-pol2qm74 7689 13 , , , cord-015021-pol2qm74 7689 14 accounts account VBZ cord-015021-pol2qm74 7689 15 for for IN cord-015021-pol2qm74 7689 16 significantly significantly RB cord-015021-pol2qm74 7689 17 increased increase VBN cord-015021-pol2qm74 7689 18 TNF TNF NNP cord-015021-pol2qm74 7689 19 secretion secretion NN cord-015021-pol2qm74 7689 20 . . . cord-015021-pol2qm74 7690 1 Opportunities opportunity NNS cord-015021-pol2qm74 7690 2 for for IN cord-015021-pol2qm74 7690 3 inhibition inhibition NN cord-015021-pol2qm74 7690 4 of of IN cord-015021-pol2qm74 7690 5 TNF TNF NNP cord-015021-pol2qm74 7690 6 production production NN cord-015021-pol2qm74 7690 7 are be VBP cord-015021-pol2qm74 7690 8 available available JJ cord-015021-pol2qm74 7690 9 at at IN cord-015021-pol2qm74 7690 10 each each DT cord-015021-pol2qm74 7690 11 of of IN cord-015021-pol2qm74 7690 12 these these DT cord-015021-pol2qm74 7690 13 two two CD cord-015021-pol2qm74 7690 14 levels level NNS cord-015021-pol2qm74 7690 15 . . . cord-015021-pol2qm74 7691 1 Agents agent NNS cord-015021-pol2qm74 7691 2 which which WDT cord-015021-pol2qm74 7691 3 increase increase VBP cord-015021-pol2qm74 7691 4 intracellular intracellular JJ cord-015021-pol2qm74 7691 5 cAMP camp NN cord-015021-pol2qm74 7692 1 ( ( -LRB- cord-015021-pol2qm74 7692 2 pentoxif¥1ine pentoxif¥1ine `` cord-015021-pol2qm74 7692 3 , , , cord-015021-pol2qm74 7692 4 amrinone amrinone NN cord-015021-pol2qm74 7692 5 ) ) -RRB- cord-015021-pol2qm74 7692 6 inhibit inhibit VBP cord-015021-pol2qm74 7692 7 accumulation accumulation NN cord-015021-pol2qm74 7692 8 of of IN cord-015021-pol2qm74 7692 9 TNF TNF NNP cord-015021-pol2qm74 7692 10 mRNA mRNA NNP cord-015021-pol2qm74 7692 11 ; ; : cord-015021-pol2qm74 7692 12 in in IN cord-015021-pol2qm74 7692 13 contrast contrast NN cord-015021-pol2qm74 7692 14 , , , cord-015021-pol2qm74 7692 15 corticosteroids corticosteroid NNS cord-015021-pol2qm74 7692 16 act act VBP cord-015021-pol2qm74 7692 17 primarily primarily RB cord-015021-pol2qm74 7692 18 at at IN cord-015021-pol2qm74 7692 19 the the DT cord-015021-pol2qm74 7692 20 level level NN cord-015021-pol2qm74 7692 21 of of IN cord-015021-pol2qm74 7692 22 translation translation NN cord-015021-pol2qm74 7692 23 , , , cord-015021-pol2qm74 7692 24 inhibiting inhibit VBG cord-015021-pol2qm74 7692 25 LPS LPS NNP cord-015021-pol2qm74 7692 26 induced induce VBD cord-015021-pol2qm74 7692 27 translational translational JJ cord-015021-pol2qm74 7692 28 activation activation NN cord-015021-pol2qm74 7692 29 . . . cord-015021-pol2qm74 7693 1 Understanding understand VBG cord-015021-pol2qm74 7693 2 the the DT cord-015021-pol2qm74 7693 3 regulation regulation NN cord-015021-pol2qm74 7693 4 of of IN cord-015021-pol2qm74 7693 5 TNF TNF NNP cord-015021-pol2qm74 7693 6 biosynthesis biosynthesis NN cord-015021-pol2qm74 7693 7 may may MD cord-015021-pol2qm74 7693 8 assist assist VB cord-015021-pol2qm74 7693 9 in in IN cord-015021-pol2qm74 7693 10 clinical clinical JJ cord-015021-pol2qm74 7693 11 strategies strategy NNS cord-015021-pol2qm74 7693 12 designed design VBN cord-015021-pol2qm74 7693 13 to to TO cord-015021-pol2qm74 7693 14 regulate regulate VB cord-015021-pol2qm74 7693 15 TNF TNF NNP cord-015021-pol2qm74 7693 16 secretion secretion NN cord-015021-pol2qm74 7693 17 . . . cord-015021-pol2qm74 7694 1 The the DT cord-015021-pol2qm74 7694 2 serine serine NN cord-015021-pol2qm74 7694 3 protease protease NN cord-015021-pol2qm74 7694 4 thrombin thrombin NN cord-015021-pol2qm74 7694 5 is be VBZ cord-015021-pol2qm74 7694 6 formed form VBN cord-015021-pol2qm74 7694 7 by by IN cord-015021-pol2qm74 7694 8 enzymatic enzymatic JJ cord-015021-pol2qm74 7694 9 conversion conversion NN cord-015021-pol2qm74 7694 10 from from IN cord-015021-pol2qm74 7694 11 its -PRON- PRP$ cord-015021-pol2qm74 7694 12 proenzyme proenzyme NNS cord-015021-pol2qm74 7694 13 form form NN cord-015021-pol2qm74 7694 14 after after IN cord-015021-pol2qm74 7694 15 coagulation coagulation NN cord-015021-pol2qm74 7694 16 activation activation NN cord-015021-pol2qm74 7694 17 and and CC cord-015021-pol2qm74 7694 18 may may MD cord-015021-pol2qm74 7694 19 enhance enhance VB cord-015021-pol2qm74 7694 20 the the DT cord-015021-pol2qm74 7694 21 inflammatory inflammatory JJ cord-015021-pol2qm74 7694 22 response response NN cord-015021-pol2qm74 7694 23 in in IN cord-015021-pol2qm74 7694 24 various various JJ cord-015021-pol2qm74 7694 25 ways way NNS cord-015021-pol2qm74 7694 26 . . . cord-015021-pol2qm74 7695 1 In in IN cord-015021-pol2qm74 7695 2 the the DT cord-015021-pol2qm74 7695 3 last last JJ cord-015021-pol2qm74 7695 4 step step NN cord-015021-pol2qm74 7695 5 of of IN cord-015021-pol2qm74 7695 6 the the DT cord-015021-pol2qm74 7695 7 coagulation coagulation NN cord-015021-pol2qm74 7695 8 cascade cascade NN cord-015021-pol2qm74 7695 9 , , , cord-015021-pol2qm74 7695 10 thrombin thrombin NN cord-015021-pol2qm74 7695 11 cleaves cleave VBZ cord-015021-pol2qm74 7695 12 its -PRON- PRP$ cord-015021-pol2qm74 7695 13 substrate substrate NN cord-015021-pol2qm74 7695 14 fibrinogen fibrinogen NN cord-015021-pol2qm74 7695 15 , , , cord-015021-pol2qm74 7695 16 thus thus RB cord-015021-pol2qm74 7695 17 forming form VBG cord-015021-pol2qm74 7695 18 fibrin fibrin NN cord-015021-pol2qm74 7695 19 . . . cord-015021-pol2qm74 7696 1 The the DT cord-015021-pol2qm74 7696 2 fibrin fibrin NN cord-015021-pol2qm74 7696 3 clot clot NN cord-015021-pol2qm74 7696 4 may may MD cord-015021-pol2qm74 7696 5 prevent prevent VB cord-015021-pol2qm74 7696 6 phagocytosis phagocytosis NN cord-015021-pol2qm74 7696 7 of of IN cord-015021-pol2qm74 7696 8 bacteria bacteria NNS cord-015021-pol2qm74 7696 9 and and CC cord-015021-pol2qm74 7696 10 promote promote VB cord-015021-pol2qm74 7696 11 local local JJ cord-015021-pol2qm74 7696 12 bacterial bacterial JJ cord-015021-pol2qm74 7696 13 growth growth NN cord-015021-pol2qm74 7696 14 . . . cord-015021-pol2qm74 7697 1 Thrombin Thrombin NNP cord-015021-pol2qm74 7697 2 can can MD cord-015021-pol2qm74 7697 3 also also RB cord-015021-pol2qm74 7697 4 stimulate stimulate VB cord-015021-pol2qm74 7697 5 a a DT cord-015021-pol2qm74 7697 6 specific specific JJ cord-015021-pol2qm74 7697 7 th.rombin th.rombin NNP cord-015021-pol2qm74 7697 8 receptor receptor NN cord-015021-pol2qm74 7697 9 that that WDT cord-015021-pol2qm74 7697 10 exists exist VBZ cord-015021-pol2qm74 7697 11 on on IN cord-015021-pol2qm74 7697 12 a a DT cord-015021-pol2qm74 7697 13 variety variety NN cord-015021-pol2qm74 7697 14 of of IN cord-015021-pol2qm74 7697 15 cells cell NNS cord-015021-pol2qm74 7697 16 . . . cord-015021-pol2qm74 7698 1 For for IN cord-015021-pol2qm74 7698 2 example example NN cord-015021-pol2qm74 7698 3 , , , cord-015021-pol2qm74 7698 4 minute minute NN cord-015021-pol2qm74 7698 5 amounts amount NNS cord-015021-pol2qm74 7698 6 of of IN cord-015021-pol2qm74 7698 7 thrombin thrombin NN cord-015021-pol2qm74 7698 8 ma ma NNP cord-015021-pol2qm74 7698 9 ) ) -RRB- cord-015021-pol2qm74 7698 10 , , , cord-015021-pol2qm74 7698 11 stimulate stimulate VBP cord-015021-pol2qm74 7698 12 platelets platelet NNS cord-015021-pol2qm74 7698 13 to to TO cord-015021-pol2qm74 7698 14 develop develop VB cord-015021-pol2qm74 7698 15 tissue tissue NN cord-015021-pol2qm74 7698 16 factor factor NN cord-015021-pol2qm74 7698 17 and and CC cord-015021-pol2qm74 7698 18 boost boost VB cord-015021-pol2qm74 7698 19 the the DT cord-015021-pol2qm74 7698 20 activation activation NN cord-015021-pol2qm74 7698 21 of of IN cord-015021-pol2qm74 7698 22 more more RBR cord-015021-pol2qm74 7698 23 thrombin thrombin NN cord-015021-pol2qm74 7698 24 , , , cord-015021-pol2qm74 7698 25 thus thus RB cord-015021-pol2qm74 7698 26 initiating initiate VBG cord-015021-pol2qm74 7698 27 a a DT cord-015021-pol2qm74 7698 28 positive positive JJ cord-015021-pol2qm74 7698 29 feedback feedback NN cord-015021-pol2qm74 7698 30 loop loop NN cord-015021-pol2qm74 7698 31 . . . cord-015021-pol2qm74 7699 1 Other other JJ cord-015021-pol2qm74 7699 2 cellular cellular JJ cord-015021-pol2qm74 7699 3 effects effect NNS cord-015021-pol2qm74 7699 4 of of IN cord-015021-pol2qm74 7699 5 thrombin thrombin JJ cord-015021-pol2qm74 7699 6 receptor receptor NN cord-015021-pol2qm74 7699 7 stimulation stimulation NN cord-015021-pol2qm74 7699 8 include include VBP cord-015021-pol2qm74 7699 9 increase increase NN cord-015021-pol2qm74 7699 10 in in IN cord-015021-pol2qm74 7699 11 intracellular intracellular JJ cord-015021-pol2qm74 7699 12 calcium calcium NN cord-015021-pol2qm74 7699 13 of of IN cord-015021-pol2qm74 7699 14 platelets platelet NNS cord-015021-pol2qm74 7699 15 and and CC cord-015021-pol2qm74 7699 16 monocytes monocyte NNS cord-015021-pol2qm74 7699 17 , , , cord-015021-pol2qm74 7699 18 contraction contraction NN cord-015021-pol2qm74 7699 19 of of IN cord-015021-pol2qm74 7699 20 smooth smooth JJ cord-015021-pol2qm74 7699 21 muscle muscle NN cord-015021-pol2qm74 7699 22 cells cell NNS cord-015021-pol2qm74 7699 23 , , , cord-015021-pol2qm74 7699 24 increase increase VBP cord-015021-pol2qm74 7699 25 in in IN cord-015021-pol2qm74 7699 26 endothelial endothelial JJ cord-015021-pol2qm74 7699 27 permeability permeability NN cord-015021-pol2qm74 7699 28 , , , cord-015021-pol2qm74 7699 29 thromboxane thromboxane NN cord-015021-pol2qm74 7699 30 generation generation NN cord-015021-pol2qm74 7699 31 by by IN cord-015021-pol2qm74 7699 32 neutrophils neutrophil NNS cord-015021-pol2qm74 7699 33 and and CC cord-015021-pol2qm74 7699 34 lymphocytes lymphocyte NNS cord-015021-pol2qm74 7699 35 , , , cord-015021-pol2qm74 7699 36 pulmonary pulmonary JJ cord-015021-pol2qm74 7699 37 vasoconstriction vasoconstriction NN cord-015021-pol2qm74 7699 38 , , , cord-015021-pol2qm74 7699 39 and and CC cord-015021-pol2qm74 7699 40 enhanced enhanced JJ cord-015021-pol2qm74 7699 41 cytokine cytokine NN cord-015021-pol2qm74 7699 42 production production NN cord-015021-pol2qm74 7699 43 . . . cord-015021-pol2qm74 7700 1 Animal animal NN cord-015021-pol2qm74 7700 2 experiments experiment NNS cord-015021-pol2qm74 7700 3 have have VBP cord-015021-pol2qm74 7700 4 been be VBN cord-015021-pol2qm74 7700 5 conducted conduct VBN cord-015021-pol2qm74 7700 6 with with IN cord-015021-pol2qm74 7700 7 a a DT cord-015021-pol2qm74 7700 8 variety variety NN cord-015021-pol2qm74 7700 9 of of IN cord-015021-pol2qm74 7700 10 thrombin thrombin NN cord-015021-pol2qm74 7700 11 inhibitors inhibitor NNS cord-015021-pol2qm74 7700 12 including include VBG cord-015021-pol2qm74 7700 13 heparin heparin VBN cord-015021-pol2qm74 7700 14 , , , cord-015021-pol2qm74 7700 15 antithrombin antithrombin NN cord-015021-pol2qm74 7700 16 IlI IlI NNP cord-015021-pol2qm74 7700 17 , , , cord-015021-pol2qm74 7700 18 hiradin hiradin NNP cord-015021-pol2qm74 7700 19 , , , cord-015021-pol2qm74 7700 20 and and CC cord-015021-pol2qm74 7700 21 hirudin hirudin NN cord-015021-pol2qm74 7700 22 - - HYPH cord-015021-pol2qm74 7700 23 like like JJ cord-015021-pol2qm74 7700 24 peptides peptide NNS cord-015021-pol2qm74 7700 25 . . . cord-015021-pol2qm74 7701 1 An an DT cord-015021-pol2qm74 7701 2 alternative alternative JJ cord-015021-pol2qm74 7701 3 approach approach NN cord-015021-pol2qm74 7701 4 is be VBZ cord-015021-pol2qm74 7701 5 the the DT cord-015021-pol2qm74 7701 6 inhibition inhibition NN cord-015021-pol2qm74 7701 7 of of IN cord-015021-pol2qm74 7701 8 the the DT cord-015021-pol2qm74 7701 9 coagulation coagulation NN cord-015021-pol2qm74 7701 10 cascade cascade NN cord-015021-pol2qm74 7701 11 at at IN cord-015021-pol2qm74 7701 12 an an DT cord-015021-pol2qm74 7701 13 earlier early JJR cord-015021-pol2qm74 7701 14 point point NN cord-015021-pol2qm74 7701 15 in in IN cord-015021-pol2qm74 7701 16 the the DT cord-015021-pol2qm74 7701 17 cascades cascade NNS cord-015021-pol2qm74 7701 18 , , , cord-015021-pol2qm74 7701 19 or or CC cord-015021-pol2qm74 7701 20 administration administration NN cord-015021-pol2qm74 7701 21 of of IN cord-015021-pol2qm74 7701 22 the the DT cord-015021-pol2qm74 7701 23 anticoagulant anticoagulant JJ cord-015021-pol2qm74 7701 24 enzyme enzyme NN cord-015021-pol2qm74 7701 25 protein protein NN cord-015021-pol2qm74 7701 26 C C NNP cord-015021-pol2qm74 7701 27 Work work NN cord-015021-pol2qm74 7701 28 from from IN cord-015021-pol2qm74 7701 29 our -PRON- PRP$ cord-015021-pol2qm74 7701 30 own own JJ cord-015021-pol2qm74 7701 31 group group NN cord-015021-pol2qm74 7701 32 in in IN cord-015021-pol2qm74 7701 33 a a DT cord-015021-pol2qm74 7701 34 porcine porcine JJ cord-015021-pol2qm74 7701 35 model model NN cord-015021-pol2qm74 7701 36 of of IN cord-015021-pol2qm74 7701 37 lipopolysaccharide-(LPS)-induced lipopolysaccharide-(LPS)-induced NNP cord-015021-pol2qm74 7701 38 shock shock NN cord-015021-pol2qm74 7701 39 with with IN cord-015021-pol2qm74 7701 40 disseminated disseminate VBN cord-015021-pol2qm74 7701 41 intravascular intravascular JJ cord-015021-pol2qm74 7701 42 coagulation coagulation NN cord-015021-pol2qm74 7701 43 has have VBZ cord-015021-pol2qm74 7701 44 shown show VBN cord-015021-pol2qm74 7701 45 that that IN cord-015021-pol2qm74 7701 46 prelreatment prelreatment JJ cord-015021-pol2qm74 7701 47 with with IN cord-015021-pol2qm74 7701 48 recombinant recombinant JJ cord-015021-pol2qm74 7701 49 desulfatohirudin desulfatohirudin NNP cord-015021-pol2qm74 7702 1 ( ( -LRB- cord-015021-pol2qm74 7702 2 r r NN cord-015021-pol2qm74 7702 3 - - HYPH cord-015021-pol2qm74 7702 4 H H NNP cord-015021-pol2qm74 7702 5 ) ) -RRB- cord-015021-pol2qm74 7702 6 or or CC cord-015021-pol2qm74 7703 1 with with IN cord-015021-pol2qm74 7703 2 a a DT cord-015021-pol2qm74 7703 3 preformed preformed JJ cord-015021-pol2qm74 7703 4 complex complex NN cord-015021-pol2qm74 7703 5 of of IN cord-015021-pol2qm74 7703 6 human human JJ cord-015021-pol2qm74 7703 7 donor donor NN cord-015021-pol2qm74 7703 8 antithrombin antithrombin NN cord-015021-pol2qm74 7703 9 III III NNP cord-015021-pol2qm74 7703 10 with with IN cord-015021-pol2qm74 7703 11 heparin heparin NN cord-015021-pol2qm74 7703 12 or or CC cord-015021-pol2qm74 7703 13 post post NN cord-015021-pol2qm74 7703 14 treatment treatment NN cord-015021-pol2qm74 7703 15 with with IN cord-015021-pol2qm74 7703 16 r r NN cord-015021-pol2qm74 7703 17 - - HYPH cord-015021-pol2qm74 7703 18 H h NN cord-015021-pol2qm74 7703 19 are be VBP cord-015021-pol2qm74 7703 20 able able JJ cord-015021-pol2qm74 7703 21 to to TO cord-015021-pol2qm74 7703 22 block block VB cord-015021-pol2qm74 7703 23 the the DT cord-015021-pol2qm74 7703 24 degradation degradation NN cord-015021-pol2qm74 7703 25 of of IN cord-015021-pol2qm74 7703 26 fibrinogen fibrinogen NN cord-015021-pol2qm74 7703 27 and and CC cord-015021-pol2qm74 7703 28 the the DT cord-015021-pol2qm74 7703 29 formation formation NN cord-015021-pol2qm74 7703 30 of of IN cord-015021-pol2qm74 7703 31 fibrin fibrin NN cord-015021-pol2qm74 7703 32 monomer monomer NN cord-015021-pol2qm74 7703 33 . . . cord-015021-pol2qm74 7704 1 In in IN cord-015021-pol2qm74 7704 2 addition addition NN cord-015021-pol2qm74 7704 3 , , , cord-015021-pol2qm74 7704 4 after after IN cord-015021-pol2qm74 7704 5 pretreatment pretreatment NN cord-015021-pol2qm74 7704 6 with with IN cord-015021-pol2qm74 7704 7 r r NN cord-015021-pol2qm74 7704 8 - - HYPH cord-015021-pol2qm74 7704 9 H h NN cord-015021-pol2qm74 7704 10 it -PRON- PRP cord-015021-pol2qm74 7704 11 was be VBD cord-015021-pol2qm74 7704 12 found find VBN cord-015021-pol2qm74 7704 13 that that IN cord-015021-pol2qm74 7704 14 LPS LPS NNP cord-015021-pol2qm74 7704 15 - - HYPH cord-015021-pol2qm74 7704 16 induced induce VBN cord-015021-pol2qm74 7704 17 lung lung NN cord-015021-pol2qm74 7704 18 injury injury NN cord-015021-pol2qm74 7704 19 was be VBD cord-015021-pol2qm74 7704 20 reduced reduce VBN cord-015021-pol2qm74 7704 21 . . . cord-015021-pol2qm74 7705 1 Since since IN cord-015021-pol2qm74 7705 2 both both DT cord-015021-pol2qm74 7705 3 natural natural JJ cord-015021-pol2qm74 7705 4 hirudin hirudin NN cord-015021-pol2qm74 7705 5 as as RB cord-015021-pol2qm74 7705 6 well well RB cord-015021-pol2qm74 7705 7 as as IN cord-015021-pol2qm74 7705 8 r r NN cord-015021-pol2qm74 7705 9 - - HYPH cord-015021-pol2qm74 7705 10 H h NN cord-015021-pol2qm74 7705 11 were be VBD cord-015021-pol2qm74 7705 12 well well RB cord-015021-pol2qm74 7705 13 tolerated tolerate VBN cord-015021-pol2qm74 7705 14 by by IN cord-015021-pol2qm74 7705 15 healthy healthy JJ cord-015021-pol2qm74 7705 16 volunteers volunteer NNS cord-015021-pol2qm74 7705 17 , , , cord-015021-pol2qm74 7705 18 adminislration adminislration NN cord-015021-pol2qm74 7705 19 of of IN cord-015021-pol2qm74 7705 20 r r NN cord-015021-pol2qm74 7705 21 - - HYPH cord-015021-pol2qm74 7705 22 H h NN cord-015021-pol2qm74 7705 23 may may MD cord-015021-pol2qm74 7705 24 be be VB cord-015021-pol2qm74 7705 25 a a DT cord-015021-pol2qm74 7705 26 promising promising JJ cord-015021-pol2qm74 7705 27 therapeutic therapeutic JJ cord-015021-pol2qm74 7705 28 approach approach NN cord-015021-pol2qm74 7705 29 in in IN cord-015021-pol2qm74 7705 30 patients patient NNS cord-015021-pol2qm74 7705 31 with with IN cord-015021-pol2qm74 7705 32 sepsis sepsis NN cord-015021-pol2qm74 7705 33 and and CC cord-015021-pol2qm74 7705 34 SIRS sirs NN cord-015021-pol2qm74 7705 35 . . . cord-015021-pol2qm74 7706 1 Corticosteroids corticosteroid NNS cord-015021-pol2qm74 7706 2 have have VBP cord-015021-pol2qm74 7706 3 been be VBN cord-015021-pol2qm74 7706 4 used use VBN cord-015021-pol2qm74 7706 5 in in IN cord-015021-pol2qm74 7706 6 the the DT cord-015021-pol2qm74 7706 7 management management NN cord-015021-pol2qm74 7706 8 of of IN cord-015021-pol2qm74 7706 9 various various JJ cord-015021-pol2qm74 7706 10 shock shock NN cord-015021-pol2qm74 7706 11 syndroms syndrom NNS cord-015021-pol2qm74 7706 12 including include VBG cord-015021-pol2qm74 7706 13 sepsis sepsis NN cord-015021-pol2qm74 7706 14 . . . cord-015021-pol2qm74 7707 1 The the DT cord-015021-pol2qm74 7707 2 data datum NNS cord-015021-pol2qm74 7707 3 concerning concern VBG cord-015021-pol2qm74 7707 4 the the DT cord-015021-pol2qm74 7707 5 effects effect NNS cord-015021-pol2qm74 7707 6 of of IN cord-015021-pol2qm74 7707 7 this this DT cord-015021-pol2qm74 7707 8 therapy therapy NN cord-015021-pol2qm74 7707 9 is be VBZ cord-015021-pol2qm74 7707 10 , , , cord-015021-pol2qm74 7707 11 however however RB cord-015021-pol2qm74 7707 12 , , , cord-015021-pol2qm74 7707 13 conflicting conflict VBG cord-015021-pol2qm74 7707 14 and and CC cord-015021-pol2qm74 7707 15 in in IN cord-015021-pol2qm74 7707 16 large large JJ cord-015021-pol2qm74 7707 17 prospective prospective JJ cord-015021-pol2qm74 7707 18 studies study NNS cord-015021-pol2qm74 7707 19 , , , cord-015021-pol2qm74 7707 20 the the DT cord-015021-pol2qm74 7707 21 use use NN cord-015021-pol2qm74 7707 22 of of IN cord-015021-pol2qm74 7707 23 early early JJ cord-015021-pol2qm74 7707 24 administration administration NN cord-015021-pol2qm74 7707 25 of of IN cord-015021-pol2qm74 7707 26 high high JJ cord-015021-pol2qm74 7707 27 doses dose NNS cord-015021-pol2qm74 7707 28 of of IN cord-015021-pol2qm74 7707 29 corticosteroids corticosteroid NNS cord-015021-pol2qm74 7707 30 have have VBP cord-015021-pol2qm74 7707 31 been be VBN cord-015021-pol2qm74 7707 32 found find VBN cord-015021-pol2qm74 7707 33 to to TO cord-015021-pol2qm74 7707 34 give give VB cord-015021-pol2qm74 7707 35 no no DT cord-015021-pol2qm74 7707 36 beneficial beneficial JJ cord-015021-pol2qm74 7707 37 effects effect NNS cord-015021-pol2qm74 7707 38 in in IN cord-015021-pol2qm74 7707 39 patients patient NNS cord-015021-pol2qm74 7707 40 with with IN cord-015021-pol2qm74 7707 41 sepsis sepsis NN cord-015021-pol2qm74 7707 42 . . . cord-015021-pol2qm74 7708 1 We -PRON- PRP cord-015021-pol2qm74 7708 2 have have VBP cord-015021-pol2qm74 7708 3 particularly particularly RB cord-015021-pol2qm74 7708 4 been be VBN cord-015021-pol2qm74 7708 5 engaged engage VBN cord-015021-pol2qm74 7708 6 in in IN cord-015021-pol2qm74 7708 7 studies study NNS cord-015021-pol2qm74 7708 8 on on IN cord-015021-pol2qm74 7708 9 possible possible JJ cord-015021-pol2qm74 7708 10 effects effect NNS cord-015021-pol2qm74 7708 11 of of IN cord-015021-pol2qm74 7708 12 corticosteroids corticosteroid NNS cord-015021-pol2qm74 7708 13 on on IN cord-015021-pol2qm74 7708 14 the the DT cord-015021-pol2qm74 7708 15 plasma plasma NN cord-015021-pol2qm74 7708 16 cascade cascade NN cord-015021-pol2qm74 7708 17 systems system NNS cord-015021-pol2qm74 7708 18 and and CC cord-015021-pol2qm74 7708 19 on on IN cord-015021-pol2qm74 7708 20 the the DT cord-015021-pol2qm74 7708 21 mediator mediator NN cord-015021-pol2qm74 7708 22 release release NN cord-015021-pol2qm74 7708 23 from from IN cord-015021-pol2qm74 7708 24 leukocytes leukocyte NNS cord-015021-pol2qm74 7708 25 . . . cord-015021-pol2qm74 7709 1 In in IN cord-015021-pol2qm74 7709 2 in in FW cord-015021-pol2qm74 7709 3 vitro vitro FW cord-015021-pol2qm74 7709 4 studies study NNS cord-015021-pol2qm74 7709 5 , , , cord-015021-pol2qm74 7709 6 high high JJ cord-015021-pol2qm74 7709 7 doses dose NNS cord-015021-pol2qm74 7709 8 of of IN cord-015021-pol2qm74 7709 9 methylprednisolone methylprednisolone NNP cord-015021-pol2qm74 7709 10 were be VBD cord-015021-pol2qm74 7709 11 found find VBN cord-015021-pol2qm74 7709 12 to to TO cord-015021-pol2qm74 7709 13 facilitate facilitate VB cord-015021-pol2qm74 7709 14 endotoxin endotoxin NN cord-015021-pol2qm74 7709 15 induced induce VBN cord-015021-pol2qm74 7709 16 generation generation NN cord-015021-pol2qm74 7709 17 of of IN cord-015021-pol2qm74 7709 18 plasma plasma NN cord-015021-pol2qm74 7709 19 kallikrein kallikrein NNP cord-015021-pol2qm74 7709 20 . . . cord-015021-pol2qm74 7710 1 Furthermore furthermore RB cord-015021-pol2qm74 7710 2 , , , cord-015021-pol2qm74 7710 3 plasma plasma NN cord-015021-pol2qm74 7710 4 prekallikrein prekallikrein NNP cord-015021-pol2qm74 7710 5 and and CC cord-015021-pol2qm74 7710 6 kallikrein kallikrein NNP cord-015021-pol2qm74 7710 7 inhibitor inhibitor NN cord-015021-pol2qm74 7710 8 values value NNS cord-015021-pol2qm74 7710 9 decreased decrease VBD cord-015021-pol2qm74 7710 10 together together RB cord-015021-pol2qm74 7710 11 with with IN cord-015021-pol2qm74 7710 12 formation formation NN cord-015021-pol2qm74 7710 13 of of IN cord-015021-pol2qm74 7710 14 kallikrein kallikrein NNP cord-015021-pol2qm74 7710 15 - - HYPH cord-015021-pol2qm74 7710 16 C1 C1 NNP cord-015021-pol2qm74 7710 17 inhibitor inhibitor NN cord-015021-pol2qm74 7710 18 complexes complex NNS cord-015021-pol2qm74 7710 19 ( ( -LRB- cord-015021-pol2qm74 7710 20 1 1 CD cord-015021-pol2qm74 7710 21 ) ) -RRB- cord-015021-pol2qm74 7710 22 . . . cord-015021-pol2qm74 7711 1 In in IN cord-015021-pol2qm74 7711 2 this this DT cord-015021-pol2qm74 7711 3 in in FW cord-015021-pol2qm74 7711 4 vitro vitro FW cord-015021-pol2qm74 7711 5 plasma plasma NN cord-015021-pol2qm74 7711 6 model model NN cord-015021-pol2qm74 7711 7 we -PRON- PRP cord-015021-pol2qm74 7711 8 also also RB cord-015021-pol2qm74 7711 9 found find VBD cord-015021-pol2qm74 7711 10 that that IN cord-015021-pol2qm74 7711 11 methylpredoisolone methylpredoisolone NN cord-015021-pol2qm74 7711 12 alone alone RB cord-015021-pol2qm74 7711 13 in in IN cord-015021-pol2qm74 7711 14 doses dose NNS cord-015021-pol2qm74 7711 15 of of IN cord-015021-pol2qm74 7711 16 1 1 CD cord-015021-pol2qm74 7711 17 mg mg NNP cord-015021-pol2qm74 7711 18 / / SYM cord-015021-pol2qm74 7711 19 ml ml NN cord-015021-pol2qm74 7711 20 induced induce VBD cord-015021-pol2qm74 7711 21 contact contact NN cord-015021-pol2qm74 7711 22 activation activation NN cord-015021-pol2qm74 7711 23 with with IN cord-015021-pol2qm74 7711 24 the the DT cord-015021-pol2qm74 7711 25 formation formation NN cord-015021-pol2qm74 7711 26 of of IN cord-015021-pol2qm74 7711 27 kallikrein kallikrein NNP cord-015021-pol2qm74 7711 28 - - HYPH cord-015021-pol2qm74 7711 29 C1 C1 NNP cord-015021-pol2qm74 7711 30 inhibitor inhibitor NN cord-015021-pol2qm74 7711 31 complexes complex NNS cord-015021-pol2qm74 7711 32 . . . cord-015021-pol2qm74 7712 1 Methylprednisolone Methylprednisolone NNP cord-015021-pol2qm74 7712 2 was be VBD cord-015021-pol2qm74 7712 3 also also RB cord-015021-pol2qm74 7712 4 found find VBN cord-015021-pol2qm74 7712 5 to to TO cord-015021-pol2qm74 7712 6 have have VB cord-015021-pol2qm74 7712 7 an an DT cord-015021-pol2qm74 7712 8 additive additive NN cord-015021-pol2qm74 7712 9 effect effect NN cord-015021-pol2qm74 7712 10 on on IN cord-015021-pol2qm74 7712 11 endotoxine endotoxine NN cord-015021-pol2qm74 7712 12 induced induce VBN cord-015021-pol2qm74 7712 13 decreases decrease VBZ cord-015021-pol2qm74 7712 14 in in IN cord-015021-pol2qm74 7712 15 kallikrein kallikrein NNP cord-015021-pol2qm74 7712 16 inhibitor inhibitor NN cord-015021-pol2qm74 7712 17 functions function NNS cord-015021-pol2qm74 7712 18 . . . cord-015021-pol2qm74 7713 1 In in IN cord-015021-pol2qm74 7713 2 the the DT cord-015021-pol2qm74 7713 3 same same JJ cord-015021-pol2qm74 7713 4 experimental experimental JJ cord-015021-pol2qm74 7713 5 model model NN cord-015021-pol2qm74 7713 6 on on IN cord-015021-pol2qm74 7713 7 endotoxemia endotoxemia NN cord-015021-pol2qm74 7713 8 methylprednisoione methylprednisoione NN cord-015021-pol2qm74 7713 9 was be VBD cord-015021-pol2qm74 7713 10 found find VBN cord-015021-pol2qm74 7713 11 to to TO cord-015021-pol2qm74 7713 12 give give VB cord-015021-pol2qm74 7713 13 an an DT cord-015021-pol2qm74 7713 14 additive additive NN cord-015021-pol2qm74 7713 15 effect effect NN cord-015021-pol2qm74 7713 16 on on IN cord-015021-pol2qm74 7713 17 activation activation NN cord-015021-pol2qm74 7713 18 of of IN cord-015021-pol2qm74 7713 19 the the DT cord-015021-pol2qm74 7713 20 initial initial JJ cord-015021-pol2qm74 7713 21 part part NN cord-015021-pol2qm74 7713 22 of of IN cord-015021-pol2qm74 7713 23 the the DT cord-015021-pol2qm74 7713 24 complement complement NN cord-015021-pol2qm74 7713 25 cascade cascade NN cord-015021-pol2qm74 7713 26 ( ( -LRB- cord-015021-pol2qm74 7713 27 2 2 CD cord-015021-pol2qm74 7713 28 ) ) -RRB- cord-015021-pol2qm74 7713 29 . . . cord-015021-pol2qm74 7714 1 Activation activation NN cord-015021-pol2qm74 7714 2 of of IN cord-015021-pol2qm74 7714 3 the the DT cord-015021-pol2qm74 7714 4 terminal terminal JJ cord-015021-pol2qm74 7714 5 part part NN cord-015021-pol2qm74 7714 6 of of IN cord-015021-pol2qm74 7714 7 complement complement NN cord-015021-pol2qm74 7714 8 , , , cord-015021-pol2qm74 7714 9 however however RB cord-015021-pol2qm74 7714 10 , , , cord-015021-pol2qm74 7714 11 was be VBD cord-015021-pol2qm74 7714 12 inhibited inhibit VBN cord-015021-pol2qm74 7714 13 by by IN cord-015021-pol2qm74 7714 14 the the DT cord-015021-pol2qm74 7714 15 same same JJ cord-015021-pol2qm74 7714 16 dose dose NN cord-015021-pol2qm74 7714 17 of of IN cord-015021-pol2qm74 7714 18 methylprednisolone methylprednisolone NN cord-015021-pol2qm74 7714 19 . . . cord-015021-pol2qm74 7715 1 Addition addition NN cord-015021-pol2qm74 7715 2 of of IN cord-015021-pol2qm74 7715 3 methylprednisolone methylprednisolone NN cord-015021-pol2qm74 7715 4 alone alone JJ cord-015021-pol2qm74 7715 5 to to IN cord-015021-pol2qm74 7715 6 plasma plasma NN cord-015021-pol2qm74 7715 7 was be VBD cord-015021-pol2qm74 7715 8 also also RB cord-015021-pol2qm74 7715 9 found find VBN cord-015021-pol2qm74 7715 10 to to TO cord-015021-pol2qm74 7715 11 activate activate VB cord-015021-pol2qm74 7715 12 the the DT cord-015021-pol2qm74 7715 13 initial initial JJ cord-015021-pol2qm74 7715 14 part part NN cord-015021-pol2qm74 7715 15 of of IN cord-015021-pol2qm74 7715 16 complement complement NN cord-015021-pol2qm74 7715 17 . . . cord-015021-pol2qm74 7716 1 Using use VBG cord-015021-pol2qm74 7716 2 a a DT cord-015021-pol2qm74 7716 3 full full JJ cord-015021-pol2qm74 7716 4 blood blood NN cord-015021-pol2qm74 7716 5 model model NN cord-015021-pol2qm74 7716 6 , , , cord-015021-pol2qm74 7716 7 we -PRON- PRP cord-015021-pol2qm74 7716 8 studied study VBD cord-015021-pol2qm74 7716 9 the the DT cord-015021-pol2qm74 7716 10 effect effect NN cord-015021-pol2qm74 7716 11 of of IN cord-015021-pol2qm74 7716 12 methylpredoisolone methylpredoisolone NN cord-015021-pol2qm74 7716 13 in in IN cord-015021-pol2qm74 7716 14 modulating modulate VBG cord-015021-pol2qm74 7716 15 the the DT cord-015021-pol2qm74 7716 16 endotoxin endotoxin NN cord-015021-pol2qm74 7716 17 induced induce VBN cord-015021-pol2qm74 7716 18 cytokine cytokine NN cord-015021-pol2qm74 7716 19 response response NN cord-015021-pol2qm74 7716 20 . . . cord-015021-pol2qm74 7717 1 When when WRB cord-015021-pol2qm74 7717 2 103 103 CD cord-015021-pol2qm74 7717 3 ng ng NNP cord-015021-pol2qm74 7717 4 / / SYM cord-015021-pol2qm74 7717 5 l l NNP cord-015021-pol2qm74 7717 6 E. E. NNP cord-015021-pol2qm74 7717 7 coli coli NNS cord-015021-pol2qm74 7717 8 endotoxin endotoxin NN cord-015021-pol2qm74 7717 9 was be VBD cord-015021-pol2qm74 7717 10 added add VBN cord-015021-pol2qm74 7717 11 to to IN cord-015021-pol2qm74 7717 12 citrated citrate VBN cord-015021-pol2qm74 7717 13 blood blood NN cord-015021-pol2qm74 7717 14 from from IN cord-015021-pol2qm74 7717 15 healthy healthy JJ cord-015021-pol2qm74 7717 16 human human JJ cord-015021-pol2qm74 7717 17 donors donor NNS cord-015021-pol2qm74 7717 18 preinkubation preinkubation NN cord-015021-pol2qm74 7717 19 with with IN cord-015021-pol2qm74 7718 1 20 20 CD cord-015021-pol2qm74 7718 2 gg gg NNP cord-015021-pol2qm74 7718 3 / / SYM cord-015021-pol2qm74 7718 4 ml ml NN cord-015021-pol2qm74 7718 5 methylprednisolone methylprednisolone NN cord-015021-pol2qm74 7718 6 significantly significantly RB cord-015021-pol2qm74 7718 7 reduced reduce VBD cord-015021-pol2qm74 7718 8 the the DT cord-015021-pol2qm74 7718 9 release release NN cord-015021-pol2qm74 7718 10 of of IN cord-015021-pol2qm74 7718 11 tumor tumor NN cord-015021-pol2qm74 7718 12 necrosis necrosis NN cord-015021-pol2qm74 7718 13 factor factor NN cord-015021-pol2qm74 7718 14 et et NNP cord-015021-pol2qm74 7718 15 ( ( -LRB- cord-015021-pol2qm74 7718 16 79 79 CD cord-015021-pol2qm74 7718 17 % % NN cord-015021-pol2qm74 7718 18 ) ) -RRB- cord-015021-pol2qm74 7718 19 and and CC cord-015021-pol2qm74 7718 20 interleukin-6 interleukin-6 NNP cord-015021-pol2qm74 7718 21 ( ( -LRB- cord-015021-pol2qm74 7718 22 63 63 CD cord-015021-pol2qm74 7718 23 % % NN cord-015021-pol2qm74 7718 24 ) ) -RRB- cord-015021-pol2qm74 7718 25 at at IN cord-015021-pol2qm74 7718 26 two two CD cord-015021-pol2qm74 7718 27 hours hour NNS cord-015021-pol2qm74 7718 28 after after IN cord-015021-pol2qm74 7718 29 exposure exposure NN cord-015021-pol2qm74 7718 30 to to IN cord-015021-pol2qm74 7718 31 endotoxin endotoxin NN cord-015021-pol2qm74 7718 32 . . . cord-015021-pol2qm74 7719 1 In in IN cord-015021-pol2qm74 7719 2 conclusion conclusion NN cord-015021-pol2qm74 7719 3 , , , cord-015021-pol2qm74 7719 4 these these DT cord-015021-pol2qm74 7719 5 studies study NNS cord-015021-pol2qm74 7719 6 show show VBP cord-015021-pol2qm74 7719 7 that that IN cord-015021-pol2qm74 7719 8 corticosteroids corticosteroid NNS cord-015021-pol2qm74 7719 9 might may MD cord-015021-pol2qm74 7719 10 facilitate facilitate VB cord-015021-pol2qm74 7719 11 contact contact NN cord-015021-pol2qm74 7719 12 activation activation NN cord-015021-pol2qm74 7719 13 of of IN cord-015021-pol2qm74 7719 14 plasma plasma NN cord-015021-pol2qm74 7719 15 and and CC cord-015021-pol2qm74 7719 16 reduce reduce VB cord-015021-pol2qm74 7719 17 the the DT cord-015021-pol2qm74 7719 18 function function NN cord-015021-pol2qm74 7719 19 of of IN cord-015021-pol2qm74 7719 20 major major JJ cord-015021-pol2qm74 7719 21 protease protease NN cord-015021-pol2qm74 7719 22 inhibitors inhibitor NNS cord-015021-pol2qm74 7719 23 . . . cord-015021-pol2qm74 7720 1 Furthermore furthermore RB cord-015021-pol2qm74 7720 2 , , , cord-015021-pol2qm74 7720 3 we -PRON- PRP cord-015021-pol2qm74 7720 4 also also RB cord-015021-pol2qm74 7720 5 observed observe VBD cord-015021-pol2qm74 7720 6 that that IN cord-015021-pol2qm74 7720 7 this this DT cord-015021-pol2qm74 7720 8 drag drag NN cord-015021-pol2qm74 7720 9 in in RP cord-015021-pol2qm74 7720 10 in in IN cord-015021-pol2qm74 7720 11 vitro vitro FW cord-015021-pol2qm74 7720 12 conditions condition NNS cord-015021-pol2qm74 7720 13 facilitated facilitate VBD cord-015021-pol2qm74 7720 14 activation activation NN cord-015021-pol2qm74 7720 15 of of IN cord-015021-pol2qm74 7720 16 complement complement NN cord-015021-pol2qm74 7720 17 . . . cord-015021-pol2qm74 7721 1 On on IN cord-015021-pol2qm74 7721 2 the the DT cord-015021-pol2qm74 7721 3 other other JJ cord-015021-pol2qm74 7721 4 hand hand NN cord-015021-pol2qm74 7721 5 , , , cord-015021-pol2qm74 7721 6 corticosteroids corticosteroid NNS cord-015021-pol2qm74 7721 7 were be VBD cord-015021-pol2qm74 7721 8 found find VBN cord-015021-pol2qm74 7721 9 to to TO cord-015021-pol2qm74 7721 10 reduce reduce VB cord-015021-pol2qm74 7721 11 endotoxin endotoxin NN cord-015021-pol2qm74 7721 12 induced induce VBN cord-015021-pol2qm74 7721 13 cytokine cytokine NN cord-015021-pol2qm74 7721 14 release release NN cord-015021-pol2qm74 7721 15 from from IN cord-015021-pol2qm74 7721 16 leukocytes leukocyte NNS cord-015021-pol2qm74 7721 17 in in IN cord-015021-pol2qm74 7721 18 whole whole JJ cord-015021-pol2qm74 7721 19 blood blood NN cord-015021-pol2qm74 7721 20 . . . cord-015021-pol2qm74 7722 1 These these DT cord-015021-pol2qm74 7722 2 studies study NNS cord-015021-pol2qm74 7722 3 also also RB cord-015021-pol2qm74 7722 4 showed show VBD cord-015021-pol2qm74 7722 5 a a DT cord-015021-pol2qm74 7722 6 dose dose JJ cord-015021-pol2qm74 7722 7 dependence dependence NN cord-015021-pol2qm74 7722 8 of of IN cord-015021-pol2qm74 7722 9 the the DT cord-015021-pol2qm74 7722 10 effects effect NNS cord-015021-pol2qm74 7722 11 of of IN cord-015021-pol2qm74 7722 12 corticosteroids corticosteroid NNS cord-015021-pol2qm74 7722 13 on on IN cord-015021-pol2qm74 7722 14 endotoxin endotoxin NN cord-015021-pol2qm74 7722 15 induced induce VBN cord-015021-pol2qm74 7722 16 cellular cellular JJ cord-015021-pol2qm74 7722 17 and and CC cord-015021-pol2qm74 7722 18 cascade cascade NN cord-015021-pol2qm74 7722 19 system system NN cord-015021-pol2qm74 7722 20 activation activation NN cord-015021-pol2qm74 7722 21 . . . cord-015021-pol2qm74 7723 1 Different different JJ cord-015021-pol2qm74 7723 2 predisposing predisposing JJ cord-015021-pol2qm74 7723 3 conditions condition NNS cord-015021-pol2qm74 7723 4 like like IN cord-015021-pol2qm74 7723 5 extensive extensive JJ cord-015021-pol2qm74 7723 6 trauma trauma NN cord-015021-pol2qm74 7723 7 , , , cord-015021-pol2qm74 7723 8 infection infection NN cord-015021-pol2qm74 7723 9 or or CC cord-015021-pol2qm74 7723 10 pancreatitis pancreatitis NN cord-015021-pol2qm74 7723 11 result result NN cord-015021-pol2qm74 7723 12 in in IN cord-015021-pol2qm74 7723 13 a a DT cord-015021-pol2qm74 7723 14 remarkably remarkably RB cord-015021-pol2qm74 7723 15 similar similar JJ cord-015021-pol2qm74 7723 16 inflammatory inflammatory JJ cord-015021-pol2qm74 7723 17 response response NN cord-015021-pol2qm74 7723 18 . . . cord-015021-pol2qm74 7724 1 Although although IN cord-015021-pol2qm74 7724 2 thls thls NNP cord-015021-pol2qm74 7724 3 inflammatory inflammatory JJ cord-015021-pol2qm74 7724 4 response response NN cord-015021-pol2qm74 7724 5 primarily primarily RB cord-015021-pol2qm74 7724 6 aims aim VBZ cord-015021-pol2qm74 7724 7 at at IN cord-015021-pol2qm74 7724 8 the the DT cord-015021-pol2qm74 7724 9 removal removal NN cord-015021-pol2qm74 7724 10 of of IN cord-015021-pol2qm74 7724 11 devitalized devitalized JJ cord-015021-pol2qm74 7724 12 tissues tissue NNS cord-015021-pol2qm74 7724 13 , , , cord-015021-pol2qm74 7724 14 destruction destruction NN cord-015021-pol2qm74 7724 15 of of IN cord-015021-pol2qm74 7724 16 bacteria bacteria NNS cord-015021-pol2qm74 7724 17 and and CC cord-015021-pol2qm74 7724 18 reestablishment reestablishment NN cord-015021-pol2qm74 7724 19 of of IN cord-015021-pol2qm74 7724 20 the the DT cord-015021-pol2qm74 7724 21 integrity integrity NN cord-015021-pol2qm74 7724 22 of of IN cord-015021-pol2qm74 7724 23 host host NN cord-015021-pol2qm74 7724 24 tissues tissue NNS cord-015021-pol2qm74 7724 25 , , , cord-015021-pol2qm74 7724 26 it -PRON- PRP cord-015021-pol2qm74 7724 27 may may MD cord-015021-pol2qm74 7724 28 potentially potentially RB cord-015021-pol2qm74 7724 29 become become VB cord-015021-pol2qm74 7724 30 unregulated unregulated JJ cord-015021-pol2qm74 7724 31 and and CC cord-015021-pol2qm74 7724 32 generalized generalized JJ cord-015021-pol2qm74 7724 33 and and CC cord-015021-pol2qm74 7724 34 thereby thereby RB cord-015021-pol2qm74 7724 35 producing produce VBG cord-015021-pol2qm74 7724 36 deleterious deleterious JJ cord-015021-pol2qm74 7724 37 effects effect NNS cord-015021-pol2qm74 7724 38 to to IN cord-015021-pol2qm74 7724 39 vital vital JJ cord-015021-pol2qm74 7724 40 organs organ NNS cord-015021-pol2qm74 7724 41 or or CC cord-015021-pol2qm74 7724 42 the the DT cord-015021-pol2qm74 7724 43 body body NN cord-015021-pol2qm74 7724 44 " " '' cord-015021-pol2qm74 7724 45 as as IN cord-015021-pol2qm74 7724 46 a a DT cord-015021-pol2qm74 7724 47 whole whole NN cord-015021-pol2qm74 7724 48 . . . cord-015021-pol2qm74 7725 1 Cytokines cytokine NNS cord-015021-pol2qm74 7725 2 play play VBP cord-015021-pol2qm74 7725 3 an an DT cord-015021-pol2qm74 7725 4 important important JJ cord-015021-pol2qm74 7725 5 role role NN cord-015021-pol2qm74 7725 6 in in IN cord-015021-pol2qm74 7725 7 the the DT cord-015021-pol2qm74 7725 8 development development NN cord-015021-pol2qm74 7725 9 of of IN cord-015021-pol2qm74 7725 10 the the DT cord-015021-pol2qm74 7725 11 systemic systemic JJ cord-015021-pol2qm74 7725 12 inflammatory inflammatory JJ cord-015021-pol2qm74 7725 13 response response NN cord-015021-pol2qm74 7725 14 . . . cord-015021-pol2qm74 7726 1 Most Most JJS cord-015021-pol2qm74 7726 2 of of IN cord-015021-pol2qm74 7726 3 their -PRON- PRP$ cord-015021-pol2qm74 7726 4 biological biological JJ cord-015021-pol2qm74 7726 5 effects effect NNS cord-015021-pol2qm74 7726 6 , , , cord-015021-pol2qm74 7726 7 however however RB cord-015021-pol2qm74 7726 8 , , , cord-015021-pol2qm74 7726 9 are be VBP cord-015021-pol2qm74 7726 10 not not RB cord-015021-pol2qm74 7726 11 directly directly RB cord-015021-pol2qm74 7726 12 mediated mediate VBN cord-015021-pol2qm74 7726 13 but but CC cord-015021-pol2qm74 7726 14 exerted exert VBN cord-015021-pol2qm74 7726 15 through through IN cord-015021-pol2qm74 7726 16 other other JJ cord-015021-pol2qm74 7726 17 mediator mediator NN cord-015021-pol2qm74 7726 18 systems system NNS cord-015021-pol2qm74 7726 19 . . . cord-015021-pol2qm74 7727 1 When when WRB cord-015021-pol2qm74 7727 2 the the DT cord-015021-pol2qm74 7727 3 inflammatory inflammatory JJ cord-015021-pol2qm74 7727 4 response response NN cord-015021-pol2qm74 7727 5 results result NNS cord-015021-pol2qm74 7727 6 in in IN cord-015021-pol2qm74 7727 7 the the DT cord-015021-pol2qm74 7727 8 formation formation NN cord-015021-pol2qm74 7727 9 of of IN cord-015021-pol2qm74 7727 10 capillary capillary JJ cord-015021-pol2qm74 7727 11 leak leak NN cord-015021-pol2qm74 7727 12 syndrome syndrome NN cord-015021-pol2qm74 7727 13 and and CC cord-015021-pol2qm74 7727 14 refractory refractory JJ cord-015021-pol2qm74 7727 15 hypotension hypotension NN cord-015021-pol2qm74 7727 16 , , , cord-015021-pol2qm74 7727 17 the the DT cord-015021-pol2qm74 7727 18 unregulated unregulated JJ cord-015021-pol2qm74 7727 19 activation activation NN cord-015021-pol2qm74 7727 20 of of IN cord-015021-pol2qm74 7727 21 complement complement NN cord-015021-pol2qm74 7727 22 and and CC cord-015021-pol2qm74 7727 23 contact contact NN cord-015021-pol2qm74 7727 24 systems system NNS cord-015021-pol2qm74 7727 25 appears appear VBZ cord-015021-pol2qm74 7727 26 to to TO cord-015021-pol2qm74 7727 27 be be VB cord-015021-pol2qm74 7727 28 the the DT cord-015021-pol2qm74 7727 29 cause cause NN cord-015021-pol2qm74 7727 30 . . . cord-015021-pol2qm74 7728 1 Both both DT cord-015021-pol2qm74 7728 2 systems system NNS cord-015021-pol2qm74 7728 3 are be VBP cord-015021-pol2qm74 7728 4 almost almost RB cord-015021-pol2qm74 7728 5 exclusively exclusively RB cord-015021-pol2qm74 7728 6 regulated regulate VBN cord-015021-pol2qm74 7728 7 by by IN cord-015021-pol2qm74 7728 8 C1 C1 NNP cord-015021-pol2qm74 7728 9 - - HYPH cord-015021-pol2qm74 7728 10 1nhibitor 1nhibitor CD cord-015021-pol2qm74 7728 11 . . . cord-015021-pol2qm74 7729 1 Am be VBP cord-015021-pol2qm74 7729 2 unbalanced unbalanced JJ cord-015021-pol2qm74 7729 3 degradation degradation NN cord-015021-pol2qm74 7729 4 of of IN cord-015021-pol2qm74 7729 5 the the DT cord-015021-pol2qm74 7729 6 inhibitor inhibitor NN cord-015021-pol2qm74 7729 7 protein protein NN cord-015021-pol2qm74 7729 8 was be VBD cord-015021-pol2qm74 7729 9 found find VBN cord-015021-pol2qm74 7729 10 to to TO cord-015021-pol2qm74 7729 11 be be VB cord-015021-pol2qm74 7729 12 associated associate VBN cord-015021-pol2qm74 7729 13 with with IN cord-015021-pol2qm74 7729 14 the the DT cord-015021-pol2qm74 7729 15 onset onset NN cord-015021-pol2qm74 7729 16 of of IN cord-015021-pol2qm74 7729 17 capillary capillary JJ cord-015021-pol2qm74 7729 18 leakage leakage NN cord-015021-pol2qm74 7729 19 in in IN cord-015021-pol2qm74 7729 20 various various JJ cord-015021-pol2qm74 7729 21 conditions condition NNS cord-015021-pol2qm74 7729 22 such such JJ cord-015021-pol2qm74 7729 23 as as IN cord-015021-pol2qm74 7729 24 bone bone NN cord-015021-pol2qm74 7729 25 marrow marrow NN cord-015021-pol2qm74 7729 26 transplantation transplantation NN cord-015021-pol2qm74 7729 27 , , , cord-015021-pol2qm74 7729 28 severe severe JJ cord-015021-pol2qm74 7729 29 burns burn NNS cord-015021-pol2qm74 7729 30 , , , cord-015021-pol2qm74 7729 31 and and CC cord-015021-pol2qm74 7729 32 septic septic JJ cord-015021-pol2qm74 7729 33 shock shock NN cord-015021-pol2qm74 7729 34 . . . cord-015021-pol2qm74 7730 1 These these DT cord-015021-pol2qm74 7730 2 observations observation NNS cord-015021-pol2qm74 7730 3 suggest suggest VBP cord-015021-pol2qm74 7730 4 a a DT cord-015021-pol2qm74 7730 5 relative relative JJ cord-015021-pol2qm74 7730 6 deficiency deficiency NN cord-015021-pol2qm74 7730 7 of of IN cord-015021-pol2qm74 7730 8 biologically biologically RB cord-015021-pol2qm74 7730 9 active active JJ cord-015021-pol2qm74 7730 10 C3 c3 NN cord-015021-pol2qm74 7730 11 - - HYPH cord-015021-pol2qm74 7730 12 1nhibitor 1nhibitor CD cord-015021-pol2qm74 7730 13 in in IN cord-015021-pol2qm74 7730 14 these these DT cord-015021-pol2qm74 7730 15 septic septic JJ cord-015021-pol2qm74 7730 16 shock shock NN cord-015021-pol2qm74 7730 17 like like IN cord-015021-pol2qm74 7730 18 syndromes syndrome NNS cord-015021-pol2qm74 7730 19 . . . cord-015021-pol2qm74 7731 1 Therapeutic therapeutic JJ cord-015021-pol2qm74 7731 2 intervention intervention NN cord-015021-pol2qm74 7731 3 studies study NNS cord-015021-pol2qm74 7731 4 were be VBD cord-015021-pol2qm74 7731 5 initiated initiate VBN cord-015021-pol2qm74 7731 6 using use VBG cord-015021-pol2qm74 7731 7 high high JJ cord-015021-pol2qm74 7731 8 doses dose NNS cord-015021-pol2qm74 7731 9 of of IN cord-015021-pol2qm74 7731 10 C1 C1 NNP cord-015021-pol2qm74 7731 11 - - HYPH cord-015021-pol2qm74 7731 12 1nhibitor 1nhibitor CD cord-015021-pol2qm74 7731 13 concentrate concentrate NN cord-015021-pol2qm74 7731 14 . . . cord-015021-pol2qm74 7732 1 First first JJ cord-015021-pol2qm74 7732 2 results result NNS cord-015021-pol2qm74 7732 3 are be VBP cord-015021-pol2qm74 7732 4 promising promising JJ cord-015021-pol2qm74 7732 5 , , , cord-015021-pol2qm74 7732 6 as as IN cord-015021-pol2qm74 7732 7 in in IN cord-015021-pol2qm74 7732 8 most most JJS cord-015021-pol2qm74 7732 9 patients patient NNS cord-015021-pol2qm74 7732 10 the the DT cord-015021-pol2qm74 7732 11 administration administration NN cord-015021-pol2qm74 7732 12 of of IN cord-015021-pol2qm74 7732 13 the the DT cord-015021-pol2qm74 7732 14 drug drug NN cord-015021-pol2qm74 7732 15 was be VBD cord-015021-pol2qm74 7732 16 followed follow VBN cord-015021-pol2qm74 7732 17 by by IN cord-015021-pol2qm74 7732 18 a a DT cord-015021-pol2qm74 7732 19 quick quick JJ cord-015021-pol2qm74 7732 20 and and CC cord-015021-pol2qm74 7732 21 marked marked JJ cord-015021-pol2qm74 7732 22 improvement improvement NN cord-015021-pol2qm74 7732 23 of of IN cord-015021-pol2qm74 7732 24 the the DT cord-015021-pol2qm74 7732 25 patient patient NN cord-015021-pol2qm74 7732 26 's 's POS cord-015021-pol2qm74 7732 27 hemodynamics hemodynamic NNS cord-015021-pol2qm74 7732 28 . . . cord-015021-pol2qm74 7733 1 Whether whether IN cord-015021-pol2qm74 7733 2 the the DT cord-015021-pol2qm74 7733 3 administration administration NN cord-015021-pol2qm74 7733 4 of of IN cord-015021-pol2qm74 7733 5 C1 C1 NNP cord-015021-pol2qm74 7733 6 - - HYPH cord-015021-pol2qm74 7733 7 1nhibitor 1nhibitor CD cord-015021-pol2qm74 7733 8 alone alone RB cord-015021-pol2qm74 7733 9 or or CC cord-015021-pol2qm74 7733 10 in in IN cord-015021-pol2qm74 7733 11 combination combination NN cord-015021-pol2qm74 7733 12 with with IN cord-015021-pol2qm74 7733 13 other other JJ cord-015021-pol2qm74 7733 14 drugs drug NNS cord-015021-pol2qm74 7733 15 is be VBZ cord-015021-pol2qm74 7733 16 also also RB cord-015021-pol2qm74 7733 17 sufficient sufficient JJ cord-015021-pol2qm74 7733 18 to to TO cord-015021-pol2qm74 7733 19 improve improve VB cord-015021-pol2qm74 7733 20 long long JJ cord-015021-pol2qm74 7733 21 - - HYPH cord-015021-pol2qm74 7733 22 time time NN cord-015021-pol2qm74 7733 23 survival survival NN cord-015021-pol2qm74 7733 24 has have VBZ cord-015021-pol2qm74 7733 25 to to TO cord-015021-pol2qm74 7733 26 be be VB cord-015021-pol2qm74 7733 27 investigated investigate VBN cord-015021-pol2qm74 7733 28 in in IN cord-015021-pol2qm74 7733 29 double double JJ cord-015021-pol2qm74 7733 30 - - HYPH cord-015021-pol2qm74 7733 31 blind blind JJ cord-015021-pol2qm74 7733 32 , , , cord-015021-pol2qm74 7733 33 placebocontrolled placebocontrolled JJ cord-015021-pol2qm74 7733 34 studies study NNS cord-015021-pol2qm74 7733 35 . . . cord-015021-pol2qm74 7734 1 SALUTARY salutary JJ cord-015021-pol2qm74 7734 2 EFFECT effect NN cord-015021-pol2qm74 7734 3 OF of IN cord-015021-pol2qm74 7734 4 HUMAN human NN cord-015021-pol2qm74 7734 5 SOLUBLE SOLUBLE NNP cord-015021-pol2qm74 7734 6 COMPLEMENT complement VBP cord-015021-pol2qm74 7734 7 RECEPTOR receptor NN cord-015021-pol2qm74 7734 8 TYPE-1 type-1 NN cord-015021-pol2qm74 7734 9 IN in IN cord-015021-pol2qm74 7734 10 MODELS model NNS cord-015021-pol2qm74 7734 11 OF of IN cord-015021-pol2qm74 7735 1 ADULT adult JJ cord-015021-pol2qm74 7735 2 RESPIRATORY respiratory JJ cord-015021-pol2qm74 7735 3 DISTRESS distress NN cord-015021-pol2qm74 7735 4 SYNDROME syndrome NN cord-015021-pol2qm74 7735 5 G. G. NNP cord-015021-pol2qm74 7735 6 Feuerstein Feuerstein NNP cord-015021-pol2qm74 7735 7 , , , cord-015021-pol2qm74 7735 8 M. M. NNP cord-015021-pol2qm74 7735 9 DiMartino DiMartino NNP cord-015021-pol2qm74 7735 10 , , , cord-015021-pol2qm74 7735 11 and and CC cord-015021-pol2qm74 7735 12 * * NFP cord-015021-pol2qm74 7735 13 R. R. NNP cord-015021-pol2qm74 7735 14 Rabinovici Rabinovici NNP cord-015021-pol2qm74 7735 15 , , , cord-015021-pol2qm74 7735 16 SmithKline SmithKline NNP cord-015021-pol2qm74 7735 17 Beecham Beecham NNP cord-015021-pol2qm74 7735 18 Pharmaceuticals Pharmaceuticals NNP cord-015021-pol2qm74 7735 19 , , , cord-015021-pol2qm74 7735 20 King King NNP cord-015021-pol2qm74 7735 21 of of IN cord-015021-pol2qm74 7735 22 Prussia Prussia NNP cord-015021-pol2qm74 7735 23 , , , cord-015021-pol2qm74 7735 24 PA PA NNP cord-015021-pol2qm74 7735 25 , , , cord-015021-pol2qm74 7735 26 USA USA NNP cord-015021-pol2qm74 7735 27 , , , cord-015021-pol2qm74 7735 28 and and CC cord-015021-pol2qm74 7735 29 * * NFP cord-015021-pol2qm74 7735 30 Jefferson Jefferson NNP cord-015021-pol2qm74 7735 31 Medical Medical NNP cord-015021-pol2qm74 7735 32 College College NNP cord-015021-pol2qm74 7735 33 , , , cord-015021-pol2qm74 7735 34 Philadelphia Philadelphia NNP cord-015021-pol2qm74 7735 35 , , , cord-015021-pol2qm74 7735 36 PA PA NNP cord-015021-pol2qm74 7735 37 , , , cord-015021-pol2qm74 7736 1 USA USA NNP cord-015021-pol2qm74 7736 2 Adult Adult NNP cord-015021-pol2qm74 7736 3 Respiratory Respiratory NNP cord-015021-pol2qm74 7736 4 Distress Distress NNP cord-015021-pol2qm74 7736 5 Syndrome Syndrome NNP cord-015021-pol2qm74 7736 6 ( ( -LRB- cord-015021-pol2qm74 7736 7 ARDS ARDS NNP cord-015021-pol2qm74 7736 8 ) ) -RRB- cord-015021-pol2qm74 7736 9 is be VBZ cord-015021-pol2qm74 7736 10 a a DT cord-015021-pol2qm74 7736 11 severe severe JJ cord-015021-pol2qm74 7736 12 pulmonary pulmonary JJ cord-015021-pol2qm74 7736 13 insufficiency insufficiency NN cord-015021-pol2qm74 7736 14 syndrome syndrome NN cord-015021-pol2qm74 7736 15 associated associate VBN cord-015021-pol2qm74 7736 16 with with IN cord-015021-pol2qm74 7736 17 diverse diverse JJ cord-015021-pol2qm74 7736 18 diseases disease NNS cord-015021-pol2qm74 7736 19 and and CC cord-015021-pol2qm74 7736 20 injuries injury NNS cord-015021-pol2qm74 7736 21 . . . cord-015021-pol2qm74 7737 1 ARDS ARDS NNP cord-015021-pol2qm74 7737 2 is be VBZ cord-015021-pol2qm74 7737 3 believed believe VBN cord-015021-pol2qm74 7737 4 to to TO cord-015021-pol2qm74 7737 5 be be VB cord-015021-pol2qm74 7737 6 the the DT cord-015021-pol2qm74 7737 7 consequence consequence NN cord-015021-pol2qm74 7737 8 of of IN cord-015021-pol2qm74 7737 9 a a DT cord-015021-pol2qm74 7737 10 massive massive JJ cord-015021-pol2qm74 7737 11 acute acute JJ cord-015021-pol2qm74 7737 12 inflammatory inflammatory JJ cord-015021-pol2qm74 7737 13 reaction reaction NN cord-015021-pol2qm74 7737 14 consisting consist VBG cord-015021-pol2qm74 7737 15 of of IN cord-015021-pol2qm74 7737 16 activated activate VBN cord-015021-pol2qm74 7737 17 neutrophils neutrophil NNS cord-015021-pol2qm74 7737 18 infiltration infiltration NN cord-015021-pol2qm74 7737 19 into into IN cord-015021-pol2qm74 7737 20 the the DT cord-015021-pol2qm74 7737 21 lung lung NN cord-015021-pol2qm74 7737 22 . . . cord-015021-pol2qm74 7738 1 Neutrophil Neutrophil NNP cord-015021-pol2qm74 7738 2 activation activation NN cord-015021-pol2qm74 7738 3 is be VBZ cord-015021-pol2qm74 7738 4 likely likely RB cord-015021-pol2qm74 7738 5 the the DT cord-015021-pol2qm74 7738 6 result result NN cord-015021-pol2qm74 7738 7 of of IN cord-015021-pol2qm74 7738 8 multiple multiple JJ cord-015021-pol2qm74 7738 9 factors factor NNS cord-015021-pol2qm74 7738 10 of of IN cord-015021-pol2qm74 7738 11 which which WDT cord-015021-pol2qm74 7738 12 complement complement NN cord-015021-pol2qm74 7738 13 is be VBZ cord-015021-pol2qm74 7738 14 believed believe VBN cord-015021-pol2qm74 7738 15 to to TO cord-015021-pol2qm74 7738 16 play play VB cord-015021-pol2qm74 7738 17 a a DT cord-015021-pol2qm74 7738 18 major major JJ cord-015021-pol2qm74 7738 19 role role NN cord-015021-pol2qm74 7738 20 . . . cord-015021-pol2qm74 7739 1 A a DT cord-015021-pol2qm74 7739 2 potent potent JJ cord-015021-pol2qm74 7739 3 complement complement NN cord-015021-pol2qm74 7739 4 regulatory regulatory JJ cord-015021-pol2qm74 7739 5 system system NN cord-015021-pol2qm74 7739 6 in in IN cord-015021-pol2qm74 7739 7 the the DT cord-015021-pol2qm74 7739 8 form form NN cord-015021-pol2qm74 7739 9 of of IN cord-015021-pol2qm74 7739 10 the the DT cord-015021-pol2qm74 7739 11 Complement Complement NNP cord-015021-pol2qm74 7739 12 Receptor Receptor NNP cord-015021-pol2qm74 7739 13 Type-1 type-1 NN cord-015021-pol2qm74 7740 1 ( ( -LRB- cord-015021-pol2qm74 7740 2 CR-1 CR-1 NNP cord-015021-pol2qm74 7740 3 ) ) -RRB- cord-015021-pol2qm74 7740 4 exists exist VBZ cord-015021-pol2qm74 7740 5 on on IN cord-015021-pol2qm74 7740 6 many many JJ cord-015021-pol2qm74 7740 7 cells cell NNS cord-015021-pol2qm74 7740 8 where where WRB cord-015021-pol2qm74 7740 9 protection protection NN cord-015021-pol2qm74 7740 10 against against IN cord-015021-pol2qm74 7740 11 complement complement JJ cord-015021-pol2qm74 7740 12 injury injury NN cord-015021-pol2qm74 7740 13 is be VBZ cord-015021-pol2qm74 7740 14 provided provide VBN cord-015021-pol2qm74 7740 15 by by IN cord-015021-pol2qm74 7740 16 inhibition inhibition NN cord-015021-pol2qm74 7740 17 of of IN cord-015021-pol2qm74 7740 18 both both CC cord-015021-pol2qm74 7740 19 the the DT cord-015021-pol2qm74 7740 20 alternative alternative JJ cord-015021-pol2qm74 7740 21 and and CC cord-015021-pol2qm74 7740 22 classical classical JJ cord-015021-pol2qm74 7740 23 pathways pathway NNS cord-015021-pol2qm74 7740 24 for for IN cord-015021-pol2qm74 7740 25 C3 C3 NNP cord-015021-pol2qm74 7740 26 / / SYM cord-015021-pol2qm74 7740 27 C5 c5 NN cord-015021-pol2qm74 7740 28 convertase convertase NN cord-015021-pol2qm74 7740 29 formation formation NN cord-015021-pol2qm74 7740 30 . . . cord-015021-pol2qm74 7741 1 We -PRON- PRP cord-015021-pol2qm74 7741 2 have have VBP cord-015021-pol2qm74 7741 3 recently recently RB cord-015021-pol2qm74 7741 4 purified purify VBN cord-015021-pol2qm74 7741 5 the the DT cord-015021-pol2qm74 7741 6 human human JJ cord-015021-pol2qm74 7741 7 recombinant recombinant JJ cord-015021-pol2qm74 7741 8 CR-1 CR-1 NNP cord-015021-pol2qm74 7741 9 in in IN cord-015021-pol2qm74 7741 10 a a DT cord-015021-pol2qm74 7741 11 truncated truncated JJ cord-015021-pol2qm74 7741 12 form form NN cord-015021-pol2qm74 7741 13 ( ( -LRB- cord-015021-pol2qm74 7741 14 BRL55730 brl55730 NN cord-015021-pol2qm74 7741 15 , , , cord-015021-pol2qm74 7741 16 TP TP NNP cord-015021-pol2qm74 7741 17 - - HYPH cord-015021-pol2qm74 7741 18 IO IO NNP cord-015021-pol2qm74 7741 19 , , , cord-015021-pol2qm74 7741 20 sCR-1 sCR-1 NNP cord-015021-pol2qm74 7741 21 ) ) -RRB- cord-015021-pol2qm74 7741 22 and and CC cord-015021-pol2qm74 7741 23 tested test VBD cord-015021-pol2qm74 7741 24 this this DT cord-015021-pol2qm74 7741 25 soluble soluble JJ cord-015021-pol2qm74 7741 26 protein protein NN cord-015021-pol2qm74 7741 27 for for IN cord-015021-pol2qm74 7741 28 protective protective JJ cord-015021-pol2qm74 7741 29 effects effect NNS cord-015021-pol2qm74 7741 30 in in IN cord-015021-pol2qm74 7741 31 several several JJ cord-015021-pol2qm74 7741 32 models model NNS cord-015021-pol2qm74 7741 33 of of IN cord-015021-pol2qm74 7741 34 ARDS ARDS NNP cord-015021-pol2qm74 7741 35 . . . cord-015021-pol2qm74 7742 1 Specifically specifically RB cord-015021-pol2qm74 7742 2 , , , cord-015021-pol2qm74 7742 3 we -PRON- PRP cord-015021-pol2qm74 7742 4 have have VBP cord-015021-pol2qm74 7742 5 used use VBN cord-015021-pol2qm74 7742 6 the the DT cord-015021-pol2qm74 7742 7 following follow VBG cord-015021-pol2qm74 7742 8 rat rat NN cord-015021-pol2qm74 7742 9 models model NNS cord-015021-pol2qm74 7742 10 : : : cord-015021-pol2qm74 7743 1 1 1 LS cord-015021-pol2qm74 7743 2 ) ) -RRB- cord-015021-pol2qm74 7743 3 endotoxin endotoxin NN cord-015021-pol2qm74 7743 4 - - HYPH cord-015021-pol2qm74 7743 5 induced induce VBN cord-015021-pol2qm74 7743 6 ARDS ARDS NNP cord-015021-pol2qm74 7743 7 in in IN cord-015021-pol2qm74 7743 8 PAF PAF NNP cord-015021-pol2qm74 7743 9 primed prime VBN cord-015021-pol2qm74 7743 10 animals animal NNS cord-015021-pol2qm74 7743 11 ; ; : cord-015021-pol2qm74 7743 12 2 2 LS cord-015021-pol2qm74 7743 13 ) ) -RRB- cord-015021-pol2qm74 7743 14 11.-2induced 11.-2induced CD cord-015021-pol2qm74 7743 15 ARDS ARDS NNP cord-015021-pol2qm74 7743 16 ; ; : cord-015021-pol2qm74 7743 17 3 3 LS cord-015021-pol2qm74 7743 18 ) ) -RRB- cord-015021-pol2qm74 7743 19 thermal thermal JJ cord-015021-pol2qm74 7743 20 injury injury NN cord-015021-pol2qm74 7743 21 ( ( -LRB- cord-015021-pol2qm74 7743 22 30 30 CD cord-015021-pol2qm74 7743 23 % % NN cord-015021-pol2qm74 7743 24 body body NN cord-015021-pol2qm74 7743 25 surface)-induced surface)-induced NNP cord-015021-pol2qm74 7743 26 ARDS ARDS NNP cord-015021-pol2qm74 7743 27 ; ; : cord-015021-pol2qm74 7743 28 4 4 LS cord-015021-pol2qm74 7743 29 ) ) -RRB- cord-015021-pol2qm74 7743 30 acid acid JJ cord-015021-pol2qm74 7743 31 aspiration aspiration NN cord-015021-pol2qm74 7743 32 - - HYPH cord-015021-pol2qm74 7743 33 induced induce VBN cord-015021-pol2qm74 7743 34 ARDS ARDS NNP cord-015021-pol2qm74 7743 35 . . . cord-015021-pol2qm74 7744 1 ARDS ARDS NNP cord-015021-pol2qm74 7744 2 - - HYPH cord-015021-pol2qm74 7744 3 like like JJ cord-015021-pol2qm74 7744 4 features feature NNS cord-015021-pol2qm74 7744 5 included include VBN cord-015021-pol2qm74 7744 6 edema edema NN cord-015021-pol2qm74 7744 7 ( ( -LRB- cord-015021-pol2qm74 7744 8 increase increase NN cord-015021-pol2qm74 7744 9 in in IN cord-015021-pol2qm74 7744 10 lung lung NN cord-015021-pol2qm74 7744 11 wet wet JJ cord-015021-pol2qm74 7744 12 weight weight NN cord-015021-pol2qm74 7744 13 and and CC cord-015021-pol2qm74 7744 14 water water NN cord-015021-pol2qm74 7744 15 content content NN cord-015021-pol2qm74 7744 16 ) ) -RRB- cord-015021-pol2qm74 7744 17 , , , cord-015021-pol2qm74 7744 18 neutrophil neutrophil NN cord-015021-pol2qm74 7744 19 accumulation accumulation NN cord-015021-pol2qm74 7744 20 ( ( -LRB- cord-015021-pol2qm74 7744 21 histological histological JJ cord-015021-pol2qm74 7744 22 inspection inspection NN cord-015021-pol2qm74 7744 23 and and CC cord-015021-pol2qm74 7744 24 myeloperoxidase myeloperoxidase NN cord-015021-pol2qm74 7744 25 assay assay NN cord-015021-pol2qm74 7744 26 ) ) -RRB- cord-015021-pol2qm74 7744 27 and and CC cord-015021-pol2qm74 7744 28 increase increase NN cord-015021-pol2qm74 7744 29 in in IN cord-015021-pol2qm74 7744 30 cells cell NNS cord-015021-pol2qm74 7744 31 and and CC cord-015021-pol2qm74 7744 32 protein protein NN cord-015021-pol2qm74 7744 33 in in IN cord-015021-pol2qm74 7744 34 the the DT cord-015021-pol2qm74 7744 35 bronchoalveolar bronchoalveolar NNP cord-015021-pol2qm74 7744 36 lavage lavage NN cord-015021-pol2qm74 7744 37 ( ( -LRB- cord-015021-pol2qm74 7744 38 BAD bad JJ cord-015021-pol2qm74 7744 39 . . . cord-015021-pol2qm74 7745 1 sCR-1 sCR-1 NNP cord-015021-pol2qm74 7745 2 , , , cord-015021-pol2qm74 7745 3 1 1 CD cord-015021-pol2qm74 7745 4 - - SYM cord-015021-pol2qm74 7745 5 25 25 CD cord-015021-pol2qm74 7745 6 mg mg NNP cord-015021-pol2qm74 7745 7 / / SYM cord-015021-pol2qm74 7745 8 kg kg NNP cord-015021-pol2qm74 7745 9 , , , cord-015021-pol2qm74 7745 10 i i PRP cord-015021-pol2qm74 7745 11 , , , cord-015021-pol2qm74 7745 12 v v NNP cord-015021-pol2qm74 7745 13 . . NNP cord-015021-pol2qm74 7745 14 , , , cord-015021-pol2qm74 7745 15 given give VBN cord-015021-pol2qm74 7745 16 as as IN cord-015021-pol2qm74 7745 17 prophylactic prophylactic JJ cord-015021-pol2qm74 7745 18 ( ( -LRB- cord-015021-pol2qm74 7745 19 and and CC cord-015021-pol2qm74 7745 20 in in IN cord-015021-pol2qm74 7745 21 some some DT cord-015021-pol2qm74 7745 22 cases case NNS cord-015021-pol2qm74 7745 23 , , , cord-015021-pol2qm74 7745 24 therapeutic therapeutic JJ cord-015021-pol2qm74 7745 25 ) ) -RRB- cord-015021-pol2qm74 7745 26 treatment treatment NN cord-015021-pol2qm74 7745 27 significantly significantly RB cord-015021-pol2qm74 7745 28 inhibited inhibit VBD cord-015021-pol2qm74 7745 29 edema edema NN cord-015021-pol2qm74 7745 30 formation formation NN cord-015021-pol2qm74 7745 31 and and CC cord-015021-pol2qm74 7745 32 leukocyte leukocyte NN cord-015021-pol2qm74 7745 33 infiltration infiltration NN cord-015021-pol2qm74 7745 34 and and CC cord-015021-pol2qm74 7745 35 , , , cord-015021-pol2qm74 7745 36 in in IN cord-015021-pol2qm74 7745 37 some some DT cord-015021-pol2qm74 7745 38 cases case NNS cord-015021-pol2qm74 7745 39 ( ( -LRB- cord-015021-pol2qm74 7745 40 e.g. e.g. RB cord-015021-pol2qm74 7745 41 , , , cord-015021-pol2qm74 7745 42 endotoxin endotoxin NN cord-015021-pol2qm74 7745 43 / / SYM cord-015021-pol2qm74 7745 44 PAF PAF NNP cord-015021-pol2qm74 7745 45 or or CC cord-015021-pol2qm74 7745 46 IL-2 IL-2 NNP cord-015021-pol2qm74 7745 47 ) ) -RRB- cord-015021-pol2qm74 7745 48 , , , cord-015021-pol2qm74 7745 49 virtually virtually RB cord-015021-pol2qm74 7745 50 completely completely RB cord-015021-pol2qm74 7745 51 . . . cord-015021-pol2qm74 7746 1 These these DT cord-015021-pol2qm74 7746 2 comprehensive comprehensive JJ cord-015021-pol2qm74 7746 3 studies study NNS cord-015021-pol2qm74 7746 4 strongly strongly RB cord-015021-pol2qm74 7746 5 support support VBP cord-015021-pol2qm74 7746 6 the the DT cord-015021-pol2qm74 7746 7 therapeutic therapeutic JJ cord-015021-pol2qm74 7746 8 potential potential NN cord-015021-pol2qm74 7746 9 of of IN cord-015021-pol2qm74 7746 10 sCR-1 sCR-1 NNP cord-015021-pol2qm74 7746 11 in in IN cord-015021-pol2qm74 7746 12 ARDS ARDS NNP cord-015021-pol2qm74 7746 13 due due IN cord-015021-pol2qm74 7746 14 to to IN cord-015021-pol2qm74 7746 15 diverse diverse JJ cord-015021-pol2qm74 7746 16 injuries injury NNS cord-015021-pol2qm74 7746 17 . . . cord-015021-pol2qm74 7747 1 The the DT cord-015021-pol2qm74 7747 2 xanthine xanthine NN cord-015021-pol2qm74 7747 3 derivative derivative JJ cord-015021-pol2qm74 7747 4 pentoxifylline pentoxifylline NN cord-015021-pol2qm74 7747 5 ( ( -LRB- cord-015021-pol2qm74 7747 6 PTX PTX NNP cord-015021-pol2qm74 7747 7 ) ) -RRB- cord-015021-pol2qm74 7747 8 and and CC cord-015021-pol2qm74 7747 9 several several JJ cord-015021-pol2qm74 7747 10 analogs analog NNS cord-015021-pol2qm74 7747 11 of of IN cord-015021-pol2qm74 7747 12 PTX PTX NNP cord-015021-pol2qm74 7747 13 have have VBP cord-015021-pol2qm74 7747 14 been be VBN cord-015021-pol2qm74 7747 15 evaluated evaluate VBN cord-015021-pol2qm74 7747 16 for for IN cord-015021-pol2qm74 7747 17 their -PRON- PRP$ cord-015021-pol2qm74 7747 18 protective protective JJ cord-015021-pol2qm74 7747 19 effect effect NN cord-015021-pol2qm74 7747 20 in in IN cord-015021-pol2qm74 7747 21 various various JJ cord-015021-pol2qm74 7747 22 animal animal NN cord-015021-pol2qm74 7747 23 models model NNS cord-015021-pol2qm74 7747 24 of of IN cord-015021-pol2qm74 7747 25 septic septic JJ cord-015021-pol2qm74 7747 26 shock shock NN cord-015021-pol2qm74 7747 27 . . . cord-015021-pol2qm74 7748 1 Data datum NNS cord-015021-pol2qm74 7748 2 from from IN cord-015021-pol2qm74 7748 3 these these DT cord-015021-pol2qm74 7748 4 in in IN cord-015021-pol2qm74 7748 5 vivo vivo NN cord-015021-pol2qm74 7748 6 studies study NNS cord-015021-pol2qm74 7748 7 demonstrate demonstrate VBP cord-015021-pol2qm74 7748 8 that that DT cord-015021-pol2qm74 7748 9 ( ( -LRB- cord-015021-pol2qm74 7748 10 1 1 CD cord-015021-pol2qm74 7748 11 ) ) -RRB- cord-015021-pol2qm74 7748 12 PTX PTX NNP cord-015021-pol2qm74 7748 13 suppresses suppress VBZ cord-015021-pol2qm74 7748 14 LPS LPS NNP cord-015021-pol2qm74 7748 15 - - HYPH cord-015021-pol2qm74 7748 16 induced induce VBN cord-015021-pol2qm74 7748 17 TNF TNF NNP cord-015021-pol2qm74 7748 18 release release NN cord-015021-pol2qm74 7748 19 from from IN cord-015021-pol2qm74 7748 20 activated activate VBN cord-015021-pol2qm74 7748 21 macrophages macrophage NNS cord-015021-pol2qm74 7748 22 ; ; , cord-015021-pol2qm74 7748 23 ( ( -LRB- cord-015021-pol2qm74 7748 24 2 2 LS cord-015021-pol2qm74 7748 25 ) ) -RRB- cord-015021-pol2qm74 7748 26 PTX PTX NNP cord-015021-pol2qm74 7748 27 prevents prevent VBZ cord-015021-pol2qm74 7748 28 TNF TNF NNP cord-015021-pol2qm74 7748 29 - - HYPH cord-015021-pol2qm74 7748 30 induced induce VBN cord-015021-pol2qm74 7748 31 PMN PMN NNP cord-015021-pol2qm74 7748 32 activation activation NN cord-015021-pol2qm74 7748 33 ; ; : cord-015021-pol2qm74 7748 34 ( ( -LRB- cord-015021-pol2qm74 7748 35 3 3 CD cord-015021-pol2qm74 7748 36 ) ) -RRB- cord-015021-pol2qm74 7748 37 PTX PTX NNP cord-015021-pol2qm74 7748 38 attenuates attenuate VBZ cord-015021-pol2qm74 7748 39 LPS LPS NNP cord-015021-pol2qm74 7748 40 - - HYPH cord-015021-pol2qm74 7748 41 or or CC cord-015021-pol2qm74 7748 42 TNFinduced tnfinduced JJ cord-015021-pol2qm74 7748 43 acute acute JJ cord-015021-pol2qm74 7748 44 lung lung NN cord-015021-pol2qm74 7748 45 injury injury NN cord-015021-pol2qm74 7748 46 as as IN cord-015021-pol2qm74 7748 47 evidenced evidence VBN cord-015021-pol2qm74 7748 48 by by IN cord-015021-pol2qm74 7748 49 prevention prevention NN cord-015021-pol2qm74 7748 50 of of IN cord-015021-pol2qm74 7748 51 increased increase VBN cord-015021-pol2qm74 7748 52 pulmonary pulmonary JJ cord-015021-pol2qm74 7748 53 vascular vascular JJ cord-015021-pol2qm74 7748 54 permeability permeability NN cord-015021-pol2qm74 7748 55 and and CC cord-015021-pol2qm74 7748 56 detoriation detoriation NN cord-015021-pol2qm74 7748 57 of of IN cord-015021-pol2qm74 7748 58 gas gas NN cord-015021-pol2qm74 7748 59 exchange exchange NN cord-015021-pol2qm74 7748 60 ; ; , cord-015021-pol2qm74 7748 61 ( ( -LRB- cord-015021-pol2qm74 7748 62 4 4 LS cord-015021-pol2qm74 7748 63 ) ) -RRB- cord-015021-pol2qm74 7748 64 PTX PTX NNP cord-015021-pol2qm74 7748 65 exerts exert VBZ cord-015021-pol2qm74 7748 66 its -PRON- PRP$ cord-015021-pol2qm74 7748 67 .protective .protective CD cord-015021-pol2qm74 7748 68 effects effect NNS cord-015021-pol2qm74 7748 69 even even RB cord-015021-pol2qm74 7748 70 when when WRB cord-015021-pol2qm74 7748 71 administered administer VBN cord-015021-pol2qm74 7748 72 following follow VBG cord-015021-pol2qm74 7748 73 initiation initiation NN cord-015021-pol2qm74 7748 74 of of IN cord-015021-pol2qm74 7748 75 sepsis sepsis NN cord-015021-pol2qm74 7748 76 . . . cord-015021-pol2qm74 7749 1 The the DT cord-015021-pol2qm74 7749 2 sum sum NN cord-015021-pol2qm74 7749 3 of of IN cord-015021-pol2qm74 7749 4 these these DT cord-015021-pol2qm74 7749 5 actions action NNS cord-015021-pol2qm74 7749 6 suggest suggest VBP cord-015021-pol2qm74 7749 7 that that IN cord-015021-pol2qm74 7749 8 administration administration NN cord-015021-pol2qm74 7749 9 of of IN cord-015021-pol2qm74 7749 10 PTX PTX NNP cord-015021-pol2qm74 7749 11 in in IN cord-015021-pol2qm74 7749 12 sepsis sepsis NN cord-015021-pol2qm74 7749 13 may may MD cord-015021-pol2qm74 7749 14 have have VB cord-015021-pol2qm74 7749 15 therapeutic therapeutic JJ cord-015021-pol2qm74 7749 16 potential potential NN cord-015021-pol2qm74 7749 17 . . . cord-015021-pol2qm74 7750 1 Hans Hans NNP cord-015021-pol2qm74 7750 2 Hoffmann Hoffmann NNP cord-015021-pol2qm74 7750 3 MD MD NNP cord-015021-pol2qm74 7750 4 , , , cord-015021-pol2qm74 7750 5 Dept Dept NNP cord-015021-pol2qm74 7750 6 . . NNP cord-015021-pol2qm74 7750 7 of of IN cord-015021-pol2qm74 7750 8 Surgery surgery NN cord-015021-pol2qm74 7750 9 , , , cord-015021-pol2qm74 7750 10 Klinikum Klinikum NNP cord-015021-pol2qm74 7750 11 Grosshadern Grosshadern NNP cord-015021-pol2qm74 7750 12 , , , cord-015021-pol2qm74 7750 13 Ludwig Ludwig NNP cord-015021-pol2qm74 7750 14 - - HYPH cord-015021-pol2qm74 7750 15 Maximilians Maximilians NNPS cord-015021-pol2qm74 7750 16 - - HYPH cord-015021-pol2qm74 7750 17 Universit~.t Universit~.t NNS cord-015021-pol2qm74 7750 18 , , , cord-015021-pol2qm74 7750 19 MarchioninJstrasse MarchioninJstrasse NNP cord-015021-pol2qm74 7750 20 15 15 CD cord-015021-pol2qm74 7750 21 , , , cord-015021-pol2qm74 7751 1 D-81377 D-81377 NNS cord-015021-pol2qm74 7752 1 M0nchen M0nchen NNP cord-015021-pol2qm74 7752 2 , , , cord-015021-pol2qm74 7752 3 Germany Germany NNP cord-015021-pol2qm74 7752 4 . . . cord-015021-pol2qm74 7753 1 Pentoxifylline Pentoxifylline NNP cord-015021-pol2qm74 7753 2 [ [ -LRB- cord-015021-pol2qm74 7753 3 POF POF NNP cord-015021-pol2qm74 7753 4 ] ] -RRB- cord-015021-pol2qm74 7753 5 and and CC cord-015021-pol2qm74 7753 6 related relate VBN cord-015021-pol2qm74 7753 7 xanthins xanthin NNS cord-015021-pol2qm74 7753 8 are be VBP cord-015021-pol2qm74 7753 9 drugs drug NNS cord-015021-pol2qm74 7753 10 of of IN cord-015021-pol2qm74 7753 11 known know VBN cord-015021-pol2qm74 7753 12 haemorrheologieal haemorrheologieal NN cord-015021-pol2qm74 7753 13 activity activity NN cord-015021-pol2qm74 7753 14 and and CC cord-015021-pol2qm74 7753 15 widely widely RB cord-015021-pol2qm74 7753 16 used use VBN cord-015021-pol2qm74 7753 17 clinically clinically RB cord-015021-pol2qm74 7753 18 . . . cord-015021-pol2qm74 7754 1 Recently recently RB cord-015021-pol2qm74 7754 2 , , , cord-015021-pol2qm74 7754 3 new new JJ cord-015021-pol2qm74 7754 4 pharmacological pharmacological JJ cord-015021-pol2qm74 7754 5 aspects aspect NNS cord-015021-pol2qm74 7754 6 of of IN cord-015021-pol2qm74 7754 7 these these DT cord-015021-pol2qm74 7754 8 established establish VBN cord-015021-pol2qm74 7754 9 drugs drug NNS cord-015021-pol2qm74 7754 10 could could MD cord-015021-pol2qm74 7754 11 be be VB cord-015021-pol2qm74 7754 12 demonstrated demonstrate VBN cord-015021-pol2qm74 7754 13 . . . cord-015021-pol2qm74 7755 1 It -PRON- PRP cord-015021-pol2qm74 7755 2 was be VBD cord-015021-pol2qm74 7755 3 found find VBN cord-015021-pol2qm74 7755 4 that that IN cord-015021-pol2qm74 7755 5 POF POF NNP cord-015021-pol2qm74 7755 6 selectively selectively RB cord-015021-pol2qm74 7755 7 inhibits inhibit VBZ cord-015021-pol2qm74 7755 8 the the DT cord-015021-pol2qm74 7755 9 formation formation NN cord-015021-pol2qm74 7755 10 of of IN cord-015021-pol2qm74 7755 11 TNF TNF NNP cord-015021-pol2qm74 7755 12 but but CC cord-015021-pol2qm74 7755 13 not not RB cord-015021-pol2qm74 7755 14 IL-6 IL-6 NNP cord-015021-pol2qm74 7755 15 most most RBS cord-015021-pol2qm74 7755 16 likely likely JJ cord-015021-pol2qm74 7755 17 by by IN cord-015021-pol2qm74 7755 18 causing cause VBG cord-015021-pol2qm74 7755 19 accumulation accumulation NN cord-015021-pol2qm74 7755 20 of of IN cord-015021-pol2qm74 7755 21 intraceliular intraceliular NNP cord-015021-pol2qm74 7755 22 cAMP cAMP NNP cord-015021-pol2qm74 7755 23 via via IN cord-015021-pol2qm74 7755 24 inhibiting inhibit VBG cord-015021-pol2qm74 7755 25 phosphodiestersse phosphodiestersse NN cord-015021-pol2qm74 7755 26 activity activity NN cord-015021-pol2qm74 7755 27 , , , cord-015021-pol2qm74 7755 28 and and CC cord-015021-pol2qm74 7755 29 , , , cord-015021-pol2qm74 7755 30 secondly secondly RB cord-015021-pol2qm74 7755 31 , , , cord-015021-pol2qm74 7755 32 by by IN cord-015021-pol2qm74 7755 33 inducing induce VBG cord-015021-pol2qm74 7755 34 prostacyclin prostacyclin NNP cord-015021-pol2qm74 7755 35 in in IN cord-015021-pol2qm74 7755 36 different different JJ cord-015021-pol2qm74 7755 37 cell cell NN cord-015021-pol2qm74 7755 38 types type NNS cord-015021-pol2qm74 7755 39 . . . cord-015021-pol2qm74 7756 1 Furthermore furthermore RB cord-015021-pol2qm74 7756 2 , , , cord-015021-pol2qm74 7756 3 POF POF NNP cord-015021-pol2qm74 7756 4 is be VBZ cord-015021-pol2qm74 7756 5 able able JJ cord-015021-pol2qm74 7756 6 to to TO cord-015021-pol2qm74 7756 7 counteract counteract VB cord-015021-pol2qm74 7756 8 TNF TNF NNP cord-015021-pol2qm74 7756 9 - - HYPH cord-015021-pol2qm74 7756 10 mediated mediate VBN cord-015021-pol2qm74 7756 11 adherence adherence NN cord-015021-pol2qm74 7756 12 of of IN cord-015021-pol2qm74 7756 13 neutrophils neutrophil NNS cord-015021-pol2qm74 7756 14 to to IN cord-015021-pol2qm74 7756 15 vascular vascular JJ cord-015021-pol2qm74 7756 16 endothelium endothelium NN cord-015021-pol2qm74 7756 17 and and CC cord-015021-pol2qm74 7756 18 to to TO cord-015021-pol2qm74 7756 19 inhibit inhibit VB cord-015021-pol2qm74 7756 20 FMLP FMLP NNP cord-015021-pol2qm74 7756 21 - - HYPH cord-015021-pol2qm74 7756 22 indueed indueed NN cord-015021-pol2qm74 7756 23 respiratory respiratory NN cord-015021-pol2qm74 7756 24 burst burst NN cord-015021-pol2qm74 7756 25 in in IN cord-015021-pol2qm74 7756 26 neutrophils neutrophil NNS cord-015021-pol2qm74 7756 27 . . . cord-015021-pol2qm74 7757 1 We -PRON- PRP cord-015021-pol2qm74 7757 2 and and CC cord-015021-pol2qm74 7757 3 others other NNS cord-015021-pol2qm74 7757 4 have have VBP cord-015021-pol2qm74 7757 5 , , , cord-015021-pol2qm74 7757 6 therefore therefore RB cord-015021-pol2qm74 7757 7 , , , cord-015021-pol2qm74 7757 8 studied study VBD cord-015021-pol2qm74 7757 9 its -PRON- PRP$ cord-015021-pol2qm74 7757 10 effect effect NN cord-015021-pol2qm74 7757 11 in in IN cord-015021-pol2qm74 7757 12 different different JJ cord-015021-pol2qm74 7757 13 animal animal NN cord-015021-pol2qm74 7757 14 models model NNS cord-015021-pol2qm74 7757 15 . . . cord-015021-pol2qm74 7758 1 It -PRON- PRP cord-015021-pol2qm74 7758 2 was be VBD cord-015021-pol2qm74 7758 3 found find VBN cord-015021-pol2qm74 7758 4 that that IN cord-015021-pol2qm74 7758 5 POF POF NNP cord-015021-pol2qm74 7758 6 protected protect VBN cord-015021-pol2qm74 7758 7 from from IN cord-015021-pol2qm74 7758 8 increased increase VBN cord-015021-pol2qm74 7758 9 pulmonary pulmonary JJ cord-015021-pol2qm74 7758 10 vascular vascular JJ cord-015021-pol2qm74 7758 11 permeability permeability NN cord-015021-pol2qm74 7758 12 and and CC cord-015021-pol2qm74 7758 13 sequestration sequestration NN cord-015021-pol2qm74 7758 14 of of IN cord-015021-pol2qm74 7758 15 neutrophils neutrophil NNS cord-015021-pol2qm74 7758 16 into into IN cord-015021-pol2qm74 7758 17 the the DT cord-015021-pol2qm74 7758 18 lung lung NN cord-015021-pol2qm74 7758 19 in in IN cord-015021-pol2qm74 7758 20 different different JJ cord-015021-pol2qm74 7758 21 animal animal NN cord-015021-pol2qm74 7758 22 models model NNS cord-015021-pol2qm74 7758 23 of of IN cord-015021-pol2qm74 7758 24 acute acute JJ cord-015021-pol2qm74 7758 25 lung lung NN cord-015021-pol2qm74 7758 26 injury injury NN cord-015021-pol2qm74 7758 27 . . . cord-015021-pol2qm74 7759 1 Moreover moreover RB cord-015021-pol2qm74 7759 2 , , , cord-015021-pol2qm74 7759 3 in in IN cord-015021-pol2qm74 7759 4 pigs pig NNS cord-015021-pol2qm74 7759 5 with with IN cord-015021-pol2qm74 7759 6 induced induce VBN cord-015021-pol2qm74 7759 7 faecal faecal JJ cord-015021-pol2qm74 7759 8 peritonitis peritonitis NN cord-015021-pol2qm74 7759 9 the the DT cord-015021-pol2qm74 7759 10 drug drug NN cord-015021-pol2qm74 7759 11 improved improve VBD cord-015021-pol2qm74 7759 12 haemodyrmmle haemodyrmmle NN cord-015021-pol2qm74 7759 13 variables variable NNS cord-015021-pol2qm74 7759 14 as as RB cord-015021-pol2qm74 7759 15 well well RB cord-015021-pol2qm74 7759 16 as as IN cord-015021-pol2qm74 7759 17 pulmonary pulmonary JJ cord-015021-pol2qm74 7759 18 compliance compliance NN cord-015021-pol2qm74 7759 19 and and CC cord-015021-pol2qm74 7759 20 reduced reduce VBD cord-015021-pol2qm74 7759 21 the the DT cord-015021-pol2qm74 7759 22 number number NN cord-015021-pol2qm74 7759 23 of of IN cord-015021-pol2qm74 7759 24 pulmonary pulmonary JJ cord-015021-pol2qm74 7759 25 neutrophila neutrophila NN cord-015021-pol2qm74 7759 26 and and CC cord-015021-pol2qm74 7759 27 lymphocytes lymphocyte NNS cord-015021-pol2qm74 7759 28 . . . cord-015021-pol2qm74 7760 1 Consequently consequently RB cord-015021-pol2qm74 7760 2 , , , cord-015021-pol2qm74 7760 3 as as IN cord-015021-pol2qm74 7760 4 a a DT cord-015021-pol2qm74 7760 5 general general JJ cord-015021-pol2qm74 7760 6 outcome outcome NN cord-015021-pol2qm74 7760 7 , , , cord-015021-pol2qm74 7760 8 POF POF NNP cord-015021-pol2qm74 7760 9 could could MD cord-015021-pol2qm74 7760 10 be be VB cord-015021-pol2qm74 7760 11 found find VBN cord-015021-pol2qm74 7760 12 to to TO cord-015021-pol2qm74 7760 13 improve improve VB cord-015021-pol2qm74 7760 14 survival survival NN cord-015021-pol2qm74 7760 15 in in IN cord-015021-pol2qm74 7760 16 different different JJ cord-015021-pol2qm74 7760 17 models model NNS cord-015021-pol2qm74 7760 18 of of IN cord-015021-pol2qm74 7760 19 haemorrhagie haemorrhagie NNP cord-015021-pol2qm74 7760 20 and and CC cord-015021-pol2qm74 7760 21 endotoxie endotoxie NNP cord-015021-pol2qm74 7760 22 shock shock NN cord-015021-pol2qm74 7760 23 . . . cord-015021-pol2qm74 7761 1 The the DT cord-015021-pol2qm74 7761 2 protective protective JJ cord-015021-pol2qm74 7761 3 effect effect NN cord-015021-pol2qm74 7761 4 of of IN cord-015021-pol2qm74 7761 5 POF POF NNP cord-015021-pol2qm74 7761 6 was be VBD cord-015021-pol2qm74 7761 7 dose dose NN cord-015021-pol2qm74 7761 8 - - HYPH cord-015021-pol2qm74 7761 9 dependent dependent JJ cord-015021-pol2qm74 7761 10 and and CC cord-015021-pol2qm74 7761 11 observed observe VBD cord-015021-pol2qm74 7761 12 even even RB cord-015021-pol2qm74 7761 13 when when WRB cord-015021-pol2qm74 7761 14 POF POF NNP cord-015021-pol2qm74 7761 15 was be VBD cord-015021-pol2qm74 7761 16 given give VBN cord-015021-pol2qm74 7761 17 up up IN cord-015021-pol2qm74 7761 18 to to TO cord-015021-pol2qm74 7761 19 4 4 CD cord-015021-pol2qm74 7761 20 hours hour NNS cord-015021-pol2qm74 7761 21 after after IN cord-015021-pol2qm74 7761 22 endotoxin endotoxin NN cord-015021-pol2qm74 7761 23 . . . cord-015021-pol2qm74 7762 1 In in IN cord-015021-pol2qm74 7762 2 order order NN cord-015021-pol2qm74 7762 3 to to TO cord-015021-pol2qm74 7762 4 evaluate evaluate VB cord-015021-pol2qm74 7762 5 these these DT cord-015021-pol2qm74 7762 6 pharmacological pharmacological JJ cord-015021-pol2qm74 7762 7 effects effect NNS cord-015021-pol2qm74 7762 8 of of IN cord-015021-pol2qm74 7762 9 POF POF NNP cord-015021-pol2qm74 7762 10 in in IN cord-015021-pol2qm74 7762 11 humans human NNS cord-015021-pol2qm74 7762 12 , , , cord-015021-pol2qm74 7762 13 we -PRON- PRP cord-015021-pol2qm74 7762 14 studied study VBD cord-015021-pol2qm74 7762 15 POF POF NNP cord-015021-pol2qm74 7762 16 under under IN cord-015021-pol2qm74 7762 17 controlled control VBN cord-015021-pol2qm74 7762 18 conditions condition NNS cord-015021-pol2qm74 7762 19 of of IN cord-015021-pol2qm74 7762 20 endotoxlnemia endotoxlnemia NN cord-015021-pol2qm74 7762 21 in in IN cord-015021-pol2qm74 7762 22 volunteers volunteer NNS cord-015021-pol2qm74 7762 23 . . . cord-015021-pol2qm74 7763 1 We -PRON- PRP cord-015021-pol2qm74 7763 2 found find VBD cord-015021-pol2qm74 7763 3 that that IN cord-015021-pol2qm74 7763 4 POF POF NNP cord-015021-pol2qm74 7763 5 selectively selectively RB cord-015021-pol2qm74 7763 6 inhibits inhibit VBZ cord-015021-pol2qm74 7763 7 the the DT cord-015021-pol2qm74 7763 8 LPS LPS NNP cord-015021-pol2qm74 7763 9 - - HYPH cord-015021-pol2qm74 7763 10 indueed indueed NN cord-015021-pol2qm74 7763 11 endogenous endogenous JJ cord-015021-pol2qm74 7763 12 formation formation NN cord-015021-pol2qm74 7763 13 of of IN cord-015021-pol2qm74 7763 14 TNF TNF NNP cord-015021-pol2qm74 7763 15 without without IN cord-015021-pol2qm74 7763 16 affecting affect VBG cord-015021-pol2qm74 7763 17 IL-6 IL-6 NNP cord-015021-pol2qm74 7763 18 and and CC cord-015021-pol2qm74 7763 19 IL-8 IL-8 NNP cord-015021-pol2qm74 7763 20 . . . cord-015021-pol2qm74 7764 1 Moreover moreover RB cord-015021-pol2qm74 7764 2 , , , cord-015021-pol2qm74 7764 3 POF POF NNP cord-015021-pol2qm74 7764 4 counteracts counteract VBZ cord-015021-pol2qm74 7764 5 the the DT cord-015021-pol2qm74 7764 6 LPS LPS NNP cord-015021-pol2qm74 7764 7 - - HYPH cord-015021-pol2qm74 7764 8 indueed indueed NNP cord-015021-pol2qm74 7764 9 initial initial JJ cord-015021-pol2qm74 7764 10 leukocytopenia leukocytopenia NNS cord-015021-pol2qm74 7764 11 by by IN cord-015021-pol2qm74 7764 12 interfering interfere VBG cord-015021-pol2qm74 7764 13 with with IN cord-015021-pol2qm74 7764 14 the the DT cord-015021-pol2qm74 7764 15 adherence adherence NN cord-015021-pol2qm74 7764 16 of of IN cord-015021-pol2qm74 7764 17 neutrophils neutrophil NNS cord-015021-pol2qm74 7764 18 in in IN cord-015021-pol2qm74 7764 19 the the DT cord-015021-pol2qm74 7764 20 microvasculature microvasculature NN cord-015021-pol2qm74 7764 21 . . . cord-015021-pol2qm74 7765 1 Meanwhile meanwhile RB cord-015021-pol2qm74 7765 2 the the DT cord-015021-pol2qm74 7765 3 inhibition inhibition NN cord-015021-pol2qm74 7765 4 of of IN cord-015021-pol2qm74 7765 5 endogenous endogenous JJ cord-015021-pol2qm74 7765 6 formation formation NN cord-015021-pol2qm74 7765 7 of of IN cord-015021-pol2qm74 7765 8 TNF TNF NNP cord-015021-pol2qm74 7765 9 by by IN cord-015021-pol2qm74 7765 10 POF POF NNP cord-015021-pol2qm74 7765 11 could could MD cord-015021-pol2qm74 7765 12 be be VB cord-015021-pol2qm74 7765 13 demonstrated demonstrate VBN cord-015021-pol2qm74 7765 14 under under IN cord-015021-pol2qm74 7765 15 different different JJ cord-015021-pol2qm74 7765 16 clinical clinical JJ cord-015021-pol2qm74 7765 17 conditions condition NNS cord-015021-pol2qm74 7765 18 of of IN cord-015021-pol2qm74 7765 19 acute acute JJ cord-015021-pol2qm74 7765 20 and and CC cord-015021-pol2qm74 7765 21 chronic chronic JJ cord-015021-pol2qm74 7765 22 cytokine cytokine NN cord-015021-pol2qm74 7765 23 release release NN cord-015021-pol2qm74 7765 24 syndromes syndrome NNS cord-015021-pol2qm74 7765 25 , , , cord-015021-pol2qm74 7765 26 { { -LRB- cord-015021-pol2qm74 7765 27 OKT3 OKT3 NNP cord-015021-pol2qm74 7765 28 first first JJ cord-015021-pol2qm74 7765 29 - - HYPH cord-015021-pol2qm74 7765 30 dose dose NN cord-015021-pol2qm74 7765 31 reaction reaction NN cord-015021-pol2qm74 7765 32 , , , cord-015021-pol2qm74 7765 33 cancer cancer NN cord-015021-pol2qm74 7765 34 - - HYPH cord-015021-pol2qm74 7765 35 or or CC cord-015021-pol2qm74 7765 36 tuberculosis tuberculosis NN cord-015021-pol2qm74 7765 37 - - HYPH cord-015021-pol2qm74 7765 38 induced induce VBN cord-015021-pol2qm74 7765 39 cachexla cachexla NN cord-015021-pol2qm74 7765 40 } } -RRB- cord-015021-pol2qm74 7765 41 . . . cord-015021-pol2qm74 7766 1 It -PRON- PRP cord-015021-pol2qm74 7766 2 appears appear VBZ cord-015021-pol2qm74 7766 3 worthwile worthwile JJ cord-015021-pol2qm74 7766 4 and and CC cord-015021-pol2qm74 7766 5 promising promise VBG cord-015021-pol2qm74 7766 6 to to TO cord-015021-pol2qm74 7766 7 investigate investigate VB cord-015021-pol2qm74 7766 8 wether wether WP cord-015021-pol2qm74 7766 9 POF POF NNP cord-015021-pol2qm74 7766 10 exhibits exhibit VBZ cord-015021-pol2qm74 7766 11 beneficial beneficial JJ cord-015021-pol2qm74 7766 12 effects effect NNS cord-015021-pol2qm74 7766 13 also also RB cord-015021-pol2qm74 7766 14 in in IN cord-015021-pol2qm74 7766 15 septic septic JJ cord-015021-pol2qm74 7766 16 patients patient NNS cord-015021-pol2qm74 7766 17 . . . cord-015021-pol2qm74 7767 1 Objectives objective NNS cord-015021-pol2qm74 7767 2 : : : cord-015021-pol2qm74 7767 3 To to TO cord-015021-pol2qm74 7767 4 determine determine VB cord-015021-pol2qm74 7767 5 the the DT cord-015021-pol2qm74 7767 6 specific specific JJ cord-015021-pol2qm74 7767 7 role role NN cord-015021-pol2qm74 7767 8 of of IN cord-015021-pol2qm74 7767 9 PAF PAF NNP cord-015021-pol2qm74 7767 10 in in IN cord-015021-pol2qm74 7767 11 both both CC cord-015021-pol2qm74 7767 12 lethal lethal JJ cord-015021-pol2qm74 7767 13 primate primate NN cord-015021-pol2qm74 7767 14 bacteremia bacteremia NN cord-015021-pol2qm74 7767 15 and and CC cord-015021-pol2qm74 7767 16 nonlethal nonlethal JJ cord-015021-pol2qm74 7767 17 human human JJ cord-015021-pol2qm74 7767 18 endotoxemia endotoxemia NN cord-015021-pol2qm74 7767 19 . . . cord-015021-pol2qm74 7768 1 Materials material NNS cord-015021-pol2qm74 7768 2 and and CC cord-015021-pol2qm74 7768 3 methods method NNS cord-015021-pol2qm74 7768 4 : : : cord-015021-pol2qm74 7768 5 Two two CD cord-015021-pol2qm74 7768 6 double double JJ cord-015021-pol2qm74 7768 7 - - HYPH cord-015021-pol2qm74 7768 8 blinded blinded JJ cord-015021-pol2qm74 7768 9 placebo placebo NN cord-015021-pol2qm74 7768 10 controlled control VBN cord-015021-pol2qm74 7768 11 studies study NNS cord-015021-pol2qm74 7768 12 were be VBD cord-015021-pol2qm74 7768 13 performed perform VBN cord-015021-pol2qm74 7768 14 . . . cord-015021-pol2qm74 7769 1 First first RB cord-015021-pol2qm74 7769 2 , , , cord-015021-pol2qm74 7769 3 ten ten CD cord-015021-pol2qm74 7769 4 baboons baboon NNS cord-015021-pol2qm74 7769 5 ( ( -LRB- cord-015021-pol2qm74 7769 6 14.5 14.5 CD cord-015021-pol2qm74 7769 7 + + CC cord-015021-pol2qm74 7769 8 .7 .7 NN cord-015021-pol2qm74 7769 9 kg kg NNP cord-015021-pol2qm74 7769 10 ) ) -RRB- cord-015021-pol2qm74 7769 11 , , , cord-015021-pol2qm74 7769 12 were be VBD cord-015021-pol2qm74 7769 13 randomized randomize VBN cord-015021-pol2qm74 7769 14 to to IN cord-015021-pol2qm74 7769 15 a a DT cord-015021-pol2qm74 7769 16 control control NN cord-015021-pol2qm74 7769 17 group group NN cord-015021-pol2qm74 7769 18 receiving receive VBG cord-015021-pol2qm74 7769 19 101 101 CD cord-015021-pol2qm74 7769 20 ° ° NNP cord-015021-pol2qm74 7769 21 cfu cfu NN cord-015021-pol2qm74 7769 22 / / SYM cord-015021-pol2qm74 7769 23 kg kg NNS cord-015021-pol2qm74 7769 24 of of IN cord-015021-pol2qm74 7769 25 intravenously intravenously RB cord-015021-pol2qm74 7769 26 administered administer VBN cord-015021-pol2qm74 7769 27 E. E. NNP cord-015021-pol2qm74 7769 28 co co NNP cord-015021-pol2qm74 7769 29 / / SYM cord-015021-pol2qm74 7769 30 i i PRP cord-015021-pol2qm74 7769 31 ( ( -LRB- cord-015021-pol2qm74 7769 32 n=5 n=5 NNP cord-015021-pol2qm74 7769 33 ) ) -RRB- cord-015021-pol2qm74 7769 34 and and CC cord-015021-pol2qm74 7769 35 a a DT cord-015021-pol2qm74 7769 36 treatment treatment NN cord-015021-pol2qm74 7769 37 group group NN cord-015021-pol2qm74 7769 38 ( ( -LRB- cord-015021-pol2qm74 7769 39 n n NN cord-015021-pol2qm74 7769 40 = = SYM cord-015021-pol2qm74 7769 41 5 5 CD cord-015021-pol2qm74 7769 42 ) ) -RRB- cord-015021-pol2qm74 7769 43 , , , cord-015021-pol2qm74 7769 44 pretreated pretreate VBN cord-015021-pol2qm74 7769 45 with with IN cord-015021-pol2qm74 7769 46 .1 .1 . cord-015021-pol2qm74 7770 1 mg mg NNP cord-015021-pol2qm74 7770 2 / / SYM cord-015021-pol2qm74 7770 3 kg kg NNP cord-015021-pol2qm74 7770 4 of of IN cord-015021-pol2qm74 7770 5 PAF PAF NNP cord-015021-pol2qm74 7770 6 receptor receptor NN cord-015021-pol2qm74 7770 7 antagonist antagonist NN cord-015021-pol2qm74 7771 1 Ro24 Ro24 NNP cord-015021-pol2qm74 7771 2 - - CD cord-015021-pol2qm74 7771 3 4736 4736 CD cord-015021-pol2qm74 7771 4 two two CD cord-015021-pol2qm74 7771 5 hours hour NNS cord-015021-pol2qm74 7771 6 prior prior RB cord-015021-pol2qm74 7771 7 to to IN cord-015021-pol2qm74 7771 8 E. E. NNP cord-015021-pol2qm74 7771 9 co co NNP cord-015021-pol2qm74 7771 10 / / SYM cord-015021-pol2qm74 7771 11 i i PRP cord-015021-pol2qm74 7771 12 infusion infusion NN cord-015021-pol2qm74 7771 13 . . . cord-015021-pol2qm74 7772 1 In in IN cord-015021-pol2qm74 7772 2 a a DT cord-015021-pol2qm74 7772 3 second second JJ cord-015021-pol2qm74 7772 4 study study NN cord-015021-pol2qm74 7772 5 , , , cord-015021-pol2qm74 7772 6 ten ten CD cord-015021-pol2qm74 7772 7 healthy healthy JJ cord-015021-pol2qm74 7772 8 male male JJ cord-015021-pol2qm74 7772 9 volunteers volunteer NNS cord-015021-pol2qm74 7772 10 were be VBD cord-015021-pol2qm74 7772 11 randomized randomize VBN cord-015021-pol2qm74 7772 12 to to IN cord-015021-pol2qm74 7772 13 a a DT cord-015021-pol2qm74 7772 14 control control NN cord-015021-pol2qm74 7772 15 group group NN cord-015021-pol2qm74 7772 16 receiving receive VBG cord-015021-pol2qm74 7772 17 4 4 CD cord-015021-pol2qm74 7772 18 ng ng NNP cord-015021-pol2qm74 7772 19 / / SYM cord-015021-pol2qm74 7772 20 kg kg NNS cord-015021-pol2qm74 7772 21 of of IN cord-015021-pol2qm74 7772 22 intravenously intravenously RB cord-015021-pol2qm74 7772 23 administered administer VBN cord-015021-pol2qm74 7772 24 endotoxin endotoxin NN cord-015021-pol2qm74 7772 25 ( ( -LRB- cord-015021-pol2qm74 7772 26 LPS LPS NNP cord-015021-pol2qm74 7772 27 ) ) -RRB- cord-015021-pol2qm74 7772 28 ( ( -LRB- cord-015021-pol2qm74 7772 29 n=5 n=5 NNP cord-015021-pol2qm74 7772 30 ) ) -RRB- cord-015021-pol2qm74 7772 31 and and CC cord-015021-pol2qm74 7772 32 a a DT cord-015021-pol2qm74 7772 33 treatment treatment NN cord-015021-pol2qm74 7772 34 group group NN cord-015021-pol2qm74 7772 35 ( ( -LRB- cord-015021-pol2qm74 7772 36 n=5 n=5 NNP cord-015021-pol2qm74 7772 37 ) ) -RRB- cord-015021-pol2qm74 7772 38 pretreated pretreate VBN cord-015021-pol2qm74 7772 39 with with IN cord-015021-pol2qm74 7772 40 10 10 CD cord-015021-pol2qm74 7772 41 mg mg NN cord-015021-pol2qm74 7772 42 of of IN cord-015021-pol2qm74 7772 43 Ro24 Ro24 NNP cord-015021-pol2qm74 7772 44 - - HYPH cord-015021-pol2qm74 7772 45 4736 4736 CD cord-015021-pol2qm74 7772 46 eighteen eighteen CD cord-015021-pol2qm74 7772 47 hours hour NNS cord-015021-pol2qm74 7772 48 prior prior RB cord-015021-pol2qm74 7772 49 to to IN cord-015021-pol2qm74 7772 50 LPS LPS NNP cord-015021-pol2qm74 7772 51 administration administration NN cord-015021-pol2qm74 7772 52 . . . cord-015021-pol2qm74 7773 1 Physiologic physiologic JJ cord-015021-pol2qm74 7773 2 parameters parameter NNS cord-015021-pol2qm74 7773 3 and and CC cord-015021-pol2qm74 7773 4 cytokine cytokine NN cord-015021-pol2qm74 7773 5 levels level NNS cord-015021-pol2qm74 7773 6 were be VBD cord-015021-pol2qm74 7773 7 measured measure VBN cord-015021-pol2qm74 7773 8 continuously continuously RB cord-015021-pol2qm74 7773 9 in in IN cord-015021-pol2qm74 7773 10 both both DT cord-015021-pol2qm74 7773 11 studies study NNS cord-015021-pol2qm74 7773 12 for for IN cord-015021-pol2qm74 7773 13 24 24 CD cord-015021-pol2qm74 7773 14 hours hour NNS cord-015021-pol2qm74 7773 15 . . . cord-015021-pol2qm74 7774 1 Results result NNS cord-015021-pol2qm74 7774 2 : : : cord-015021-pol2qm74 7775 1 Baboons baboon NNS cord-015021-pol2qm74 7775 2 pretreated pretreate VBD cord-015021-pol2qm74 7775 3 with with IN cord-015021-pol2qm74 7775 4 the the DT cord-015021-pol2qm74 7775 5 PAF PAF NNP cord-015021-pol2qm74 7775 6 antagonist antagonist NN cord-015021-pol2qm74 7775 7 had have VBD cord-015021-pol2qm74 7775 8 improved improve VBN cord-015021-pol2qm74 7775 9 oxygenation oxygenation NN cord-015021-pol2qm74 7775 10 ( ( -LRB- cord-015021-pol2qm74 7775 11 96 96 CD cord-015021-pol2qm74 7775 12 + + SYM cord-015021-pol2qm74 7775 13 11 11 CD cord-015021-pol2qm74 7775 14 mm mm NN cord-015021-pol2qm74 7776 1 Hg Hg NNP cord-015021-pol2qm74 7776 2 v v NN cord-015021-pol2qm74 7776 3 59 59 CD cord-015021-pol2qm74 7776 4 -+ -+ NNP cord-015021-pol2qm74 7776 5 6 6 CD cord-015021-pol2qm74 7776 6 in in IN cord-015021-pol2qm74 7776 7 controls control NNS cord-015021-pol2qm74 7776 8 , , , cord-015021-pol2qm74 7776 9 p p NN cord-015021-pol2qm74 7776 10 < < XX cord-015021-pol2qm74 7776 11 0.05 0.05 CD cord-015021-pol2qm74 7776 12 ) ) -RRB- cord-015021-pol2qm74 7776 13 and and CC cord-015021-pol2qm74 7776 14 creatinine creatinine NN cord-015021-pol2qm74 7776 15 clearance clearance NN cord-015021-pol2qm74 7777 1 12 12 CD cord-015021-pol2qm74 7777 2 hours hour NNS cord-015021-pol2qm74 7777 3 post post NN cord-015021-pol2qm74 7777 4 E.coli E.coli NNS cord-015021-pol2qm74 7777 5 ( ( -LRB- cord-015021-pol2qm74 7778 1 39.8 39.8 CD cord-015021-pol2qm74 7778 2 + + SYM cord-015021-pol2qm74 7778 3 23.4 23.4 CD cord-015021-pol2qm74 7778 4 ml ml NNS cord-015021-pol2qm74 7778 5 / / SYM cord-015021-pol2qm74 7778 6 min min NN cord-015021-pol2qm74 7778 7 v v NN cord-015021-pol2qm74 7778 8 0.1 0.1 CD cord-015021-pol2qm74 7778 9 _ _ NN cord-015021-pol2qm74 7778 10 + + SYM cord-015021-pol2qm74 7778 11 0.1 0.1 CD cord-015021-pol2qm74 7778 12 in in IN cord-015021-pol2qm74 7778 13 controls control NNS cord-015021-pol2qm74 7778 14 , , , cord-015021-pol2qm74 7778 15 p p NN cord-015021-pol2qm74 7778 16 < < XX cord-015021-pol2qm74 7778 17 0.05 0.05 CD cord-015021-pol2qm74 7778 18 ) ) -RRB- cord-015021-pol2qm74 7778 19 . . . cord-015021-pol2qm74 7779 1 Similarly similarly RB cord-015021-pol2qm74 7779 2 , , , cord-015021-pol2qm74 7779 3 volunteers volunteer NNS cord-015021-pol2qm74 7779 4 pretreated pretreate VBD cord-015021-pol2qm74 7779 5 with with IN cord-015021-pol2qm74 7779 6 the the DT cord-015021-pol2qm74 7779 7 PAF PAF NNP cord-015021-pol2qm74 7779 8 antagonist antagonist NN cord-015021-pol2qm74 7779 9 experienced experience VBD cord-015021-pol2qm74 7779 10 fewer few JJR cord-015021-pol2qm74 7779 11 symptoms symptom NNS cord-015021-pol2qm74 7779 12 , , , cord-015021-pol2qm74 7779 13 including include VBG cord-015021-pol2qm74 7779 14 rigors rigor NNS cord-015021-pol2qm74 7779 15 and and CC cord-015021-pol2qm74 7779 16 myalgias myalgia NNS cord-015021-pol2qm74 7779 17 at at IN cord-015021-pol2qm74 7779 18 1 1 CD cord-015021-pol2qm74 7779 19 hour hour NN cord-015021-pol2qm74 7779 20 post post NN cord-015021-pol2qm74 7779 21 LPS lp NNS cord-015021-pol2qm74 7779 22 . . . cord-015021-pol2qm74 7780 1 This this DT cord-015021-pol2qm74 7780 2 was be VBD cord-015021-pol2qm74 7780 3 in in IN cord-015021-pol2qm74 7780 4 concert concert NN cord-015021-pol2qm74 7780 5 with with IN cord-015021-pol2qm74 7780 6 a a DT cord-015021-pol2qm74 7780 7 diminished diminished JJ cord-015021-pol2qm74 7780 8 peak peak NN cord-015021-pol2qm74 7780 9 cortisol cortisol NN cord-015021-pol2qm74 7780 10 ( ( -LRB- cord-015021-pol2qm74 7780 11 668 668 CD cord-015021-pol2qm74 7780 12 + + CC cord-015021-pol2qm74 7780 13 _ _ NN cord-015021-pol2qm74 7780 14 107 107 CD cord-015021-pol2qm74 7780 15 mmot mmot NNP cord-015021-pol2qm74 7780 16 / / SYM cord-015021-pol2qm74 7780 17 L l NN cord-015021-pol2qm74 7780 18 v v NN cord-015021-pol2qm74 7780 19 959 959 CD cord-015021-pol2qm74 7781 1 + + CC cord-015021-pol2qm74 7782 1 -159 -159 NNP cord-015021-pol2qm74 7782 2 mmol mmol NNP cord-015021-pol2qm74 7782 3 / / SYM cord-015021-pol2qm74 7782 4 L L NNP cord-015021-pol2qm74 7782 5 in in IN cord-015021-pol2qm74 7782 6 controls control NNS cord-015021-pol2qm74 7782 7 , , , cord-015021-pol2qm74 7782 8 p p NN cord-015021-pol2qm74 7782 9 < < XX cord-015021-pol2qm74 7782 10 0.05 0.05 CD cord-015021-pol2qm74 7782 11 ) ) -RRB- cord-015021-pol2qm74 7782 12 , , , cord-015021-pol2qm74 7782 13 epinephrine epinephrine NN cord-015021-pol2qm74 7782 14 secretion secretion NN cord-015021-pol2qm74 7782 15 ( ( -LRB- cord-015021-pol2qm74 7782 16 1057 1057 CD cord-015021-pol2qm74 7782 17 + + CC cord-015021-pol2qm74 7783 1 165 165 CD cord-015021-pol2qm74 7783 2 nmol nmol NNP cord-015021-pol2qm74 7783 3 / / SYM cord-015021-pol2qm74 7783 4 L l NN cord-015021-pol2qm74 7783 5 v v NNP cord-015021-pol2qm74 7783 6 2029 2029 CD cord-015021-pol2qm74 7783 7 + + SYM cord-015021-pol2qm74 7783 8 431 431 CD cord-015021-pol2qm74 7783 9 nmol nmol NNP cord-015021-pol2qm74 7783 10 / / SYM cord-015021-pol2qm74 7783 11 L l NN cord-015021-pol2qm74 7783 12 in in IN cord-015021-pol2qm74 7783 13 controls control NNS cord-015021-pol2qm74 7783 14 , , , cord-015021-pol2qm74 7783 15 p p NN cord-015021-pol2qm74 7783 16 < < XX cord-015021-pol2qm74 7783 17 0.05 0.05 CD cord-015021-pol2qm74 7783 18 ) ) -RRB- cord-015021-pol2qm74 7783 19 . . . cord-015021-pol2qm74 7784 1 Hemodynamics hemodynamic NNS cord-015021-pol2qm74 7784 2 and and CC cord-015021-pol2qm74 7784 3 circulating circulate VBG cord-015021-pol2qm74 7784 4 TNFa TNFa NNP cord-015021-pol2qm74 7784 5 levels level NNS cord-015021-pol2qm74 7784 6 ( ( -LRB- cord-015021-pol2qm74 7784 7 data datum NNS cord-015021-pol2qm74 7784 8 not not RB cord-015021-pol2qm74 7784 9 shown show VBN cord-015021-pol2qm74 7784 10 ) ) -RRB- cord-015021-pol2qm74 7784 11 were be VBD cord-015021-pol2qm74 7784 12 unaffected unaffected JJ cord-015021-pol2qm74 7784 13 in in IN cord-015021-pol2qm74 7784 14 either either DT cord-015021-pol2qm74 7784 15 study study NN cord-015021-pol2qm74 7784 16 by by IN cord-015021-pol2qm74 7784 17 prior prior JJ cord-015021-pol2qm74 7784 18 PAF PAF NNP cord-015021-pol2qm74 7784 19 antagonism antagonism NN cord-015021-pol2qm74 7784 20 . . . cord-015021-pol2qm74 7785 1 Concluslons concluslon NNS cord-015021-pol2qm74 7785 2 : : : cord-015021-pol2qm74 7786 1 PAF PAF NNP cord-015021-pol2qm74 7786 2 influences influence VBZ cord-015021-pol2qm74 7786 3 some some DT cord-015021-pol2qm74 7786 4 components component NNS cord-015021-pol2qm74 7786 5 of of IN cord-015021-pol2qm74 7786 6 the the DT cord-015021-pol2qm74 7786 7 multi multi JJ cord-015021-pol2qm74 7786 8 - - JJ cord-015021-pol2qm74 7786 9 organ organ JJ cord-015021-pol2qm74 7786 10 failure failure NN cord-015021-pol2qm74 7786 11 syndrome syndrome NN cord-015021-pol2qm74 7786 12 in in IN cord-015021-pol2qm74 7786 13 lethal lethal JJ cord-015021-pol2qm74 7786 14 gram gram NN cord-015021-pol2qm74 7786 15 negative negative JJ cord-015021-pol2qm74 7786 16 sepsis sepsis NN cord-015021-pol2qm74 7786 17 and and CC cord-015021-pol2qm74 7786 18 the the DT cord-015021-pol2qm74 7786 19 counter counter JJ cord-015021-pol2qm74 7786 20 - - JJ cord-015021-pol2qm74 7786 21 regulatory regulatory JJ cord-015021-pol2qm74 7786 22 hormonal hormonal JJ cord-015021-pol2qm74 7786 23 system system NN cord-015021-pol2qm74 7786 24 in in IN cord-015021-pol2qm74 7786 25 human human JJ cord-015021-pol2qm74 7786 26 endotoxemia endotoxemia NN cord-015021-pol2qm74 7786 27 through through IN cord-015021-pol2qm74 7786 28 TNF TNF NNP cord-015021-pol2qm74 7786 29 - - HYPH cord-015021-pol2qm74 7786 30 independent independent JJ cord-015021-pol2qm74 7786 31 mechanisms mechanism NNS cord-015021-pol2qm74 7786 32 . . . cord-015021-pol2qm74 7787 1 PAF PAF NNP cord-015021-pol2qm74 7787 2 antagonists antagonist NNS cord-015021-pol2qm74 7787 3 may may MD cord-015021-pol2qm74 7787 4 serve serve VB cord-015021-pol2qm74 7787 5 as as IN cord-015021-pol2qm74 7787 6 adjuncts adjunct NNS cord-015021-pol2qm74 7787 7 to to IN cord-015021-pol2qm74 7787 8 cytokine cytokine NN cord-015021-pol2qm74 7787 9 blockade blockade NN cord-015021-pol2qm74 7787 10 in in IN cord-015021-pol2qm74 7787 11 the the DT cord-015021-pol2qm74 7787 12 treatment treatment NN cord-015021-pol2qm74 7787 13 of of IN cord-015021-pol2qm74 7787 14 gram gram NN cord-015021-pol2qm74 7787 15 negative negative JJ cord-015021-pol2qm74 7787 16 sepsis sepsis NN cord-015021-pol2qm74 7787 17 . . . cord-015021-pol2qm74 7788 1 The the DT cord-015021-pol2qm74 7788 2 mediator mediator NN cord-015021-pol2qm74 7788 3 Role role NN cord-015021-pol2qm74 7788 4 of of IN cord-015021-pol2qm74 7788 5 Platelet platelet NN cord-015021-pol2qm74 7788 6 - - HYPH cord-015021-pol2qm74 7788 7 Activating activate VBG cord-015021-pol2qm74 7788 8 Factor factor NN cord-015021-pol2qm74 7788 9 in in IN cord-015021-pol2qm74 7788 10 Gramnegative Gramnegative NNP cord-015021-pol2qm74 7788 11 Septic Septic NNP cord-015021-pol2qm74 7788 12 Shock Shock NNP cord-015021-pol2qm74 7788 13 Pierre Pierre NNP cord-015021-pol2qm74 7788 14 G. G. NNP cord-015021-pol2qm74 7788 15 Braquet Braquet NNP cord-015021-pol2qm74 7788 16 , , , cord-015021-pol2qm74 7788 17 David David NNP cord-015021-pol2qm74 7788 18 Hosford Hosford NNP cord-015021-pol2qm74 7788 19 and and CC cord-015021-pol2qm74 7788 20 Matyas Matyas NNP cord-015021-pol2qm74 7788 21 Koltai Koltai NNP cord-015021-pol2qm74 7789 1 Institut Institut NNP cord-015021-pol2qm74 7789 2 Henri Henri NNP cord-015021-pol2qm74 7789 3 Beaufour Beaufour NNP cord-015021-pol2qm74 7789 4 , , , cord-015021-pol2qm74 7789 5 Le Le NNP cord-015021-pol2qm74 7789 6 Plessis Plessis NNP cord-015021-pol2qm74 7789 7 Robinson Robinson NNP cord-015021-pol2qm74 7789 8 , , , cord-015021-pol2qm74 7789 9 France France NNP cord-015021-pol2qm74 7789 10 Considerable considerable JJ cord-015021-pol2qm74 7789 11 evidence evidence NN cord-015021-pol2qm74 7789 12 has have VBZ cord-015021-pol2qm74 7789 13 been be VBN cord-015021-pol2qm74 7789 14 accumulated accumulate VBN cord-015021-pol2qm74 7789 15 to to TO cord-015021-pol2qm74 7789 16 support support VB cord-015021-pol2qm74 7789 17 the the DT cord-015021-pol2qm74 7789 18 concept concept NN cord-015021-pol2qm74 7789 19 that that IN cord-015021-pol2qm74 7789 20 a a DT cord-015021-pol2qm74 7789 21 PAF PAF NNP cord-015021-pol2qm74 7789 22 / / SYM cord-015021-pol2qm74 7789 23 cytokine cytokine JJ cord-015021-pol2qm74 7789 24 autogenerated autogenerated JJ cord-015021-pol2qm74 7789 25 feedback feedback NN cord-015021-pol2qm74 7789 26 network network NN cord-015021-pol2qm74 7789 27 is be VBZ cord-015021-pol2qm74 7789 28 responsible responsible JJ cord-015021-pol2qm74 7789 29 for for IN cord-015021-pol2qm74 7789 30 priming priming NN cord-015021-pol2qm74 7789 31 and and CC cord-015021-pol2qm74 7789 32 amplification amplification NN cord-015021-pol2qm74 7789 33 of of IN cord-015021-pol2qm74 7789 34 inflammatory inflammatory JJ cord-015021-pol2qm74 7789 35 mediator mediator NN cord-015021-pol2qm74 7789 36 release release NN cord-015021-pol2qm74 7789 37 in in IN cord-015021-pol2qm74 7789 38 septic septic JJ cord-015021-pol2qm74 7789 39 shock shock NN cord-015021-pol2qm74 7789 40 . . . cord-015021-pol2qm74 7790 1 Cytokines cytokine NNS cord-015021-pol2qm74 7790 2 , , , cord-015021-pol2qm74 7790 3 such such JJ cord-015021-pol2qm74 7790 4 as as IN cord-015021-pol2qm74 7790 5 TNF~ tnf~ CD cord-015021-pol2qm74 7791 1 x x LS cord-015021-pol2qm74 7791 2 , , , cord-015021-pol2qm74 7791 3 IL-1 IL-1 NNP cord-015021-pol2qm74 7791 4 and and CC cord-015021-pol2qm74 7791 5 other other JJ cord-015021-pol2qm74 7791 6 interleukins interleukin NNS cord-015021-pol2qm74 7791 7 interact interact VBP cord-015021-pol2qm74 7791 8 with with IN cord-015021-pol2qm74 7791 9 PAF PAF NNP cord-015021-pol2qm74 7791 10 which which WDT cord-015021-pol2qm74 7791 11 then then RB cord-015021-pol2qm74 7791 12 amplifies amplify VBZ cord-015021-pol2qm74 7791 13 cytokine cytokine JJ cord-015021-pol2qm74 7791 14 production production NN cord-015021-pol2qm74 7791 15 , , , cord-015021-pol2qm74 7791 16 therefore therefore RB cord-015021-pol2qm74 7791 17 , , , cord-015021-pol2qm74 7791 18 PAF PAF NNP cord-015021-pol2qm74 7791 19 may may MD cord-015021-pol2qm74 7791 20 be be VB cord-015021-pol2qm74 7791 21 the the DT cord-015021-pol2qm74 7791 22 principle principle JJ cord-015021-pol2qm74 7791 23 mediator mediator NN cord-015021-pol2qm74 7791 24 in in IN cord-015021-pol2qm74 7791 25 endotoxin endotoxin NN cord-015021-pol2qm74 7791 26 shock shock NN cord-015021-pol2qm74 7791 27 . . . cord-015021-pol2qm74 7792 1 A a DT cord-015021-pol2qm74 7792 2 single single JJ cord-015021-pol2qm74 7792 3 factor factor NN cord-015021-pol2qm74 7792 4 identified identify VBN cord-015021-pol2qm74 7792 5 as as IN cord-015021-pol2qm74 7792 6 TNF TNF NNP cord-015021-pol2qm74 7792 7 is be VBZ cord-015021-pol2qm74 7792 8 suggested suggest VBN cord-015021-pol2qm74 7792 9 to to TO cord-015021-pol2qm74 7792 10 play play VB cord-015021-pol2qm74 7792 11 a a DT cord-015021-pol2qm74 7792 12 pivotal pivotal JJ cord-015021-pol2qm74 7792 13 role role NN cord-015021-pol2qm74 7792 14 in in IN cord-015021-pol2qm74 7792 15 the the DT cord-015021-pol2qm74 7792 16 fatal fatal JJ cord-015021-pol2qm74 7792 17 phase phase NN cord-015021-pol2qm74 7792 18 of of IN cord-015021-pol2qm74 7792 19 septic septic JJ cord-015021-pol2qm74 7792 20 shock shock NN cord-015021-pol2qm74 7792 21 . . . cord-015021-pol2qm74 7793 1 Presumably presumably RB cord-015021-pol2qm74 7793 2 excess excess JJ cord-015021-pol2qm74 7793 3 TNF TNF NNP cord-015021-pol2qm74 7793 4 release release NN cord-015021-pol2qm74 7793 5 is be VBZ cord-015021-pol2qm74 7793 6 the the DT cord-015021-pol2qm74 7793 7 result result NN cord-015021-pol2qm74 7793 8 of of IN cord-015021-pol2qm74 7793 9 amplification amplification NN cord-015021-pol2qm74 7793 10 process process NN cord-015021-pol2qm74 7793 11 primarily primarily RB cord-015021-pol2qm74 7793 12 triggered trigger VBN cord-015021-pol2qm74 7793 13 by by IN cord-015021-pol2qm74 7793 14 PAF PAF NNP cord-015021-pol2qm74 7793 15 . . . cord-015021-pol2qm74 7794 1 One one CD cord-015021-pol2qm74 7794 2 may may MD cord-015021-pol2qm74 7794 3 assume assume VB cord-015021-pol2qm74 7794 4 that that IN cord-015021-pol2qm74 7794 5 the the DT cord-015021-pol2qm74 7794 6 high high JJ cord-015021-pol2qm74 7794 7 TNF TNF NNP cord-015021-pol2qm74 7794 8 concentration concentration NN cord-015021-pol2qm74 7794 9 in in IN cord-015021-pol2qm74 7794 10 the the DT cord-015021-pol2qm74 7794 11 blood blood NN cord-015021-pol2qm74 7794 12 of of IN cord-015021-pol2qm74 7794 13 ' ' `` cord-015021-pol2qm74 7794 14 non non JJ cord-015021-pol2qm74 7794 15 survivors survivor NNS cord-015021-pol2qm74 7794 16 ' ' POS cord-015021-pol2qm74 7794 17 is be VBZ cord-015021-pol2qm74 7794 18 the the DT cord-015021-pol2qm74 7794 19 consequence consequence NN cord-015021-pol2qm74 7794 20 rather rather RB cord-015021-pol2qm74 7794 21 than than IN cord-015021-pol2qm74 7794 22 the the DT cord-015021-pol2qm74 7794 23 cause cause NN cord-015021-pol2qm74 7794 24 of of IN cord-015021-pol2qm74 7794 25 cell cell NN cord-015021-pol2qm74 7794 26 death death NN cord-015021-pol2qm74 7794 27 . . . cord-015021-pol2qm74 7795 1 The the DT cord-015021-pol2qm74 7795 2 dubious dubious JJ cord-015021-pol2qm74 7795 3 results result NNS cord-015021-pol2qm74 7795 4 of of IN cord-015021-pol2qm74 7795 5 clinical clinical JJ cord-015021-pol2qm74 7795 6 trials trial NNS cord-015021-pol2qm74 7795 7 with with IN cord-015021-pol2qm74 7795 8 anti anti JJ cord-015021-pol2qm74 7795 9 - - JJ cord-015021-pol2qm74 7795 10 TNF tnf JJ cord-015021-pol2qm74 7795 11 antibodies antibody NNS cord-015021-pol2qm74 7795 12 and and CC cord-015021-pol2qm74 7795 13 IL-1Ra IL-1Ra NNP cord-015021-pol2qm74 7795 14 , , , cord-015021-pol2qm74 7795 15 a a DT cord-015021-pol2qm74 7795 16 naturally naturally RB cord-015021-pol2qm74 7795 17 occurring occur VBG cord-015021-pol2qm74 7795 18 IL-1 IL-1 NNP cord-015021-pol2qm74 7795 19 antagonist antagonist NN cord-015021-pol2qm74 7795 20 protein protein NN cord-015021-pol2qm74 7795 21 , , , cord-015021-pol2qm74 7795 22 have have VBP cord-015021-pol2qm74 7795 23 risen rise VBN cord-015021-pol2qm74 7795 24 debate debate NN cord-015021-pol2qm74 7795 25 around around IN cord-015021-pol2qm74 7795 26 the the DT cord-015021-pol2qm74 7795 27 exceptional exceptional JJ cord-015021-pol2qm74 7795 28 role role NN cord-015021-pol2qm74 7795 29 of of IN cord-015021-pol2qm74 7795 30 cytokines cytokine NNS cord-015021-pol2qm74 7795 31 in in IN cord-015021-pol2qm74 7795 32 the the DT cord-015021-pol2qm74 7795 33 pathomechanism pathomechanism NN cord-015021-pol2qm74 7795 34 of of IN cord-015021-pol2qm74 7795 35 septic septic JJ cord-015021-pol2qm74 7795 36 shock shock NN cord-015021-pol2qm74 7795 37 or or CC cord-015021-pol2qm74 7795 38 systemic systemic JJ cord-015021-pol2qm74 7795 39 inflammatory inflammatory JJ cord-015021-pol2qm74 7795 40 response response NN cord-015021-pol2qm74 7795 41 syndrome syndrome NN cord-015021-pol2qm74 7795 42 ( ( -LRB- cord-015021-pol2qm74 7795 43 SIRS SIRS NNP cord-015021-pol2qm74 7795 44 ) ) -RRB- cord-015021-pol2qm74 7795 45 induced induce VBN cord-015021-pol2qm74 7795 46 by by IN cord-015021-pol2qm74 7795 47 Gramnegative Gramnegative NNP cord-015021-pol2qm74 7795 48 microorganisms microorganism NNS cord-015021-pol2qm74 7795 49 . . . cord-015021-pol2qm74 7796 1 There there EX cord-015021-pol2qm74 7796 2 are be VBP cord-015021-pol2qm74 7796 3 similar similar JJ cord-015021-pol2qm74 7796 4 problems problem NNS cord-015021-pol2qm74 7796 5 with with IN cord-015021-pol2qm74 7796 6 the the DT cord-015021-pol2qm74 7796 7 interpretation interpretation NN cord-015021-pol2qm74 7796 8 of of IN cord-015021-pol2qm74 7796 9 the the DT cord-015021-pol2qm74 7796 10 results result NNS cord-015021-pol2qm74 7796 11 obtained obtain VBN cord-015021-pol2qm74 7796 12 in in IN cord-015021-pol2qm74 7796 13 clinical clinical JJ cord-015021-pol2qm74 7796 14 trials trial NNS cord-015021-pol2qm74 7796 15 of of IN cord-015021-pol2qm74 7796 16 monoclonal monoclonal JJ cord-015021-pol2qm74 7796 17 IgM IgM NNP cord-015021-pol2qm74 7796 18 antibodies antibody NNS cord-015021-pol2qm74 7796 19 against against IN cord-015021-pol2qm74 7796 20 E. E. NNP cord-015021-pol2qm74 7796 21 coli coli NNS cord-015021-pol2qm74 7796 22 endotoxin endotoxin NN cord-015021-pol2qm74 7796 23 , , , cord-015021-pol2qm74 7796 24 HA-1A HA-1A NNP cord-015021-pol2qm74 7796 25 and and CC cord-015021-pol2qm74 7796 26 E5 E5 NNP cord-015021-pol2qm74 7796 27 . . . cord-015021-pol2qm74 7797 1 Future future JJ cord-015021-pol2qm74 7797 2 studies study NNS cord-015021-pol2qm74 7797 3 will will MD cord-015021-pol2qm74 7797 4 answer answer VB cord-015021-pol2qm74 7797 5 the the DT cord-015021-pol2qm74 7797 6 question question NN cord-015021-pol2qm74 7797 7 as as IN cord-015021-pol2qm74 7797 8 to to IN cord-015021-pol2qm74 7797 9 the the DT cord-015021-pol2qm74 7797 10 effectivity effectivity NN cord-015021-pol2qm74 7797 11 of of IN cord-015021-pol2qm74 7797 12 inefficiency inefficiency NN cord-015021-pol2qm74 7797 13 of of IN cord-015021-pol2qm74 7797 14 this this DT cord-015021-pol2qm74 7797 15 treatment treatment NN cord-015021-pol2qm74 7797 16 . . . cord-015021-pol2qm74 7798 1 Perhaps perhaps RB cord-015021-pol2qm74 7798 2 when when WRB cord-015021-pol2qm74 7798 3 the the DT cord-015021-pol2qm74 7798 4 plasma plasma NN cord-015021-pol2qm74 7798 5 concentrations concentration NNS cord-015021-pol2qm74 7798 6 of of IN cord-015021-pol2qm74 7798 7 LPS lp NNS cord-015021-pol2qm74 7798 8 and and CC cord-015021-pol2qm74 7798 9 cytokines cytokine NNS cord-015021-pol2qm74 7798 10 exceed exceed VBP cord-015021-pol2qm74 7798 11 a a DT cord-015021-pol2qm74 7798 12 critical critical JJ cord-015021-pol2qm74 7798 13 level level NN cord-015021-pol2qm74 7798 14 , , , cord-015021-pol2qm74 7798 15 treatment treatment NN cord-015021-pol2qm74 7798 16 fails fail VBZ cord-015021-pol2qm74 7798 17 to to TO cord-015021-pol2qm74 7798 18 save save VB cord-015021-pol2qm74 7798 19 the the DT cord-015021-pol2qm74 7798 20 patients patient NNS cord-015021-pol2qm74 7798 21 life life NN cord-015021-pol2qm74 7798 22 . . . cord-015021-pol2qm74 7799 1 With with IN cord-015021-pol2qm74 7799 2 regard regard VB cord-015021-pol2qm74 7799 3 the the DT cord-015021-pol2qm74 7799 4 causal causal JJ cord-015021-pol2qm74 7799 5 role role NN cord-015021-pol2qm74 7799 6 of of IN cord-015021-pol2qm74 7799 7 LPS LPS NNP cord-015021-pol2qm74 7799 8 in in IN cord-015021-pol2qm74 7799 9 septic septic JJ cord-015021-pol2qm74 7799 10 shock shock NN cord-015021-pol2qm74 7799 11 , , , cord-015021-pol2qm74 7799 12 the the DT cord-015021-pol2qm74 7799 13 putative putative JJ cord-015021-pol2qm74 7799 14 role role NN cord-015021-pol2qm74 7799 15 of of IN cord-015021-pol2qm74 7799 16 bacterial bacterial JJ cord-015021-pol2qm74 7799 17 porins porin NNS cord-015021-pol2qm74 7799 18 may may MD cord-015021-pol2qm74 7799 19 have have VB cord-015021-pol2qm74 7799 20 to to TO cord-015021-pol2qm74 7799 21 be be VB cord-015021-pol2qm74 7799 22 taken take VBN cord-015021-pol2qm74 7799 23 into into IN cord-015021-pol2qm74 7799 24 consideration consideration NN cord-015021-pol2qm74 7799 25 . . . cord-015021-pol2qm74 7800 1 The the DT cord-015021-pol2qm74 7800 2 marked marked JJ cord-015021-pol2qm74 7800 3 release release NN cord-015021-pol2qm74 7800 4 of of IN cord-015021-pol2qm74 7800 5 PAF PAF NNP cord-015021-pol2qm74 7800 6 induced induce VBN cord-015021-pol2qm74 7800 7 by by IN cord-015021-pol2qm74 7800 8 endotoxin endotoxin NN cord-015021-pol2qm74 7800 9 leading lead VBG cord-015021-pol2qm74 7800 10 to to IN cord-015021-pol2qm74 7800 11 excess excess JJ cord-015021-pol2qm74 7800 12 TXA2 TXA2 NNP cord-015021-pol2qm74 7800 13 production production NN cord-015021-pol2qm74 7800 14 may may MD cord-015021-pol2qm74 7800 15 be be VB cord-015021-pol2qm74 7800 16 responsible responsible JJ cord-015021-pol2qm74 7800 17 for for IN cord-015021-pol2qm74 7800 18 the the DT cord-015021-pol2qm74 7800 19 microvascular microvascular JJ cord-015021-pol2qm74 7800 20 failure failure NN cord-015021-pol2qm74 7800 21 and and CC cord-015021-pol2qm74 7800 22 death death NN cord-015021-pol2qm74 7800 23 in in IN cord-015021-pol2qm74 7800 24 septic septic JJ cord-015021-pol2qm74 7800 25 shock shock NN cord-015021-pol2qm74 7800 26 . . . cord-015021-pol2qm74 7801 1 Antagonists antagonist NNS cord-015021-pol2qm74 7801 2 of of IN cord-015021-pol2qm74 7801 3 PAF PAF NNP cord-015021-pol2qm74 7801 4 markedly markedly RB cord-015021-pol2qm74 7801 5 protect protect VBP cord-015021-pol2qm74 7801 6 against against IN cord-015021-pol2qm74 7801 7 the the DT cord-015021-pol2qm74 7801 8 release release NN cord-015021-pol2qm74 7801 9 of of IN cord-015021-pol2qm74 7801 10 TXA2 TXA2 NNP cord-015021-pol2qm74 7801 11 , , , cord-015021-pol2qm74 7801 12 and and CC cord-015021-pol2qm74 7801 13 may may MD cord-015021-pol2qm74 7801 14 interrupt interrupt VB cord-015021-pol2qm74 7801 15 the the DT cord-015021-pol2qm74 7801 16 vicious vicious JJ cord-015021-pol2qm74 7801 17 circle circle NN cord-015021-pol2qm74 7801 18 of of IN cord-015021-pol2qm74 7801 19 amplification amplification NN cord-015021-pol2qm74 7801 20 process process NN cord-015021-pol2qm74 7801 21 . . . cord-015021-pol2qm74 7802 1 NO no DT cord-015021-pol2qm74 7802 2 produced produce VBN cord-015021-pol2qm74 7802 3 by by IN cord-015021-pol2qm74 7802 4 the the DT cord-015021-pol2qm74 7802 5 inducible inducible JJ cord-015021-pol2qm74 7802 6 NO no DT cord-015021-pol2qm74 7802 7 synthase synthase NN cord-015021-pol2qm74 7802 8 plays play VBZ cord-015021-pol2qm74 7802 9 a a DT cord-015021-pol2qm74 7802 10 pivotal pivotal JJ cord-015021-pol2qm74 7802 11 role role NN cord-015021-pol2qm74 7802 12 in in IN cord-015021-pol2qm74 7802 13 causing cause VBG cord-015021-pol2qm74 7802 14 vascular vascular JJ cord-015021-pol2qm74 7802 15 paralysis paralysis NN cord-015021-pol2qm74 7802 16 in in IN cord-015021-pol2qm74 7802 17 LPS LPS NNP cord-015021-pol2qm74 7802 18 - - HYPH cord-015021-pol2qm74 7802 19 induced induce VBN cord-015021-pol2qm74 7802 20 SIRS SIRS NNP cord-015021-pol2qm74 7802 21 . . . cord-015021-pol2qm74 7803 1 To to TO cord-015021-pol2qm74 7803 2 explore explore VB cord-015021-pol2qm74 7803 3 the the DT cord-015021-pol2qm74 7803 4 relationship relationship NN cord-015021-pol2qm74 7803 5 of of IN cord-015021-pol2qm74 7803 6 PAF PAF NNP cord-015021-pol2qm74 7803 7 to to IN cord-015021-pol2qm74 7803 8 NO no DT cord-015021-pol2qm74 7803 9 synthesis synthesis NN cord-015021-pol2qm74 7803 10 will will MD cord-015021-pol2qm74 7803 11 provide provide VB cord-015021-pol2qm74 7803 12 better well JJR cord-015021-pol2qm74 7803 13 understanding understanding NN cord-015021-pol2qm74 7803 14 of of IN cord-015021-pol2qm74 7803 15 the the DT cord-015021-pol2qm74 7803 16 pathomechanism pathomechanism NN cord-015021-pol2qm74 7803 17 of of IN cord-015021-pol2qm74 7803 18 septic septic JJ cord-015021-pol2qm74 7803 19 shock shock NN cord-015021-pol2qm74 7803 20 . . . cord-015021-pol2qm74 7804 1 Several several JJ cord-015021-pol2qm74 7804 2 PAF PAF NNP cord-015021-pol2qm74 7804 3 antagonists antagonist NNS cord-015021-pol2qm74 7804 4 , , , cord-015021-pol2qm74 7804 5 including include VBG cord-015021-pol2qm74 7804 6 BN BN NNP cord-015021-pol2qm74 7804 7 52021 52021 CD cord-015021-pol2qm74 7804 8 , , , cord-015021-pol2qm74 7804 9 have have VBP cord-015021-pol2qm74 7804 10 undergone undergo VBN cord-015021-pol2qm74 7804 11 phase phase NN cord-015021-pol2qm74 7804 12 II II NNP cord-015021-pol2qm74 7804 13 and and CC cord-015021-pol2qm74 7804 14 phase phase NN cord-015021-pol2qm74 7804 15 III iii CD cord-015021-pol2qm74 7804 16 clinical clinical JJ cord-015021-pol2qm74 7804 17 trials trial NNS cord-015021-pol2qm74 7804 18 . . . cord-015021-pol2qm74 7805 1 The the DT cord-015021-pol2qm74 7805 2 strategy strategy NN cord-015021-pol2qm74 7805 3 in in IN cord-015021-pol2qm74 7805 4 the the DT cord-015021-pol2qm74 7805 5 treatment treatment NN cord-015021-pol2qm74 7805 6 of of IN cord-015021-pol2qm74 7805 7 SIRS SIRS NNP cord-015021-pol2qm74 7805 8 , , , cord-015021-pol2qm74 7805 9 however however RB cord-015021-pol2qm74 7805 10 , , , cord-015021-pol2qm74 7805 11 remains remain VBZ cord-015021-pol2qm74 7805 12 multifactorial multifactorial JJ cord-015021-pol2qm74 7805 13 , , , cord-015021-pol2qm74 7805 14 since since IN cord-015021-pol2qm74 7805 15 little little JJ cord-015021-pol2qm74 7805 16 is be VBZ cord-015021-pol2qm74 7805 17 known know VBN cord-015021-pol2qm74 7805 18 about about IN cord-015021-pol2qm74 7805 19 the the DT cord-015021-pol2qm74 7805 20 SIRS SIRS NNP cord-015021-pol2qm74 7805 21 caused cause VBN cord-015021-pol2qm74 7805 22 by by IN cord-015021-pol2qm74 7805 23 microorganisms microorganism NNS cord-015021-pol2qm74 7805 24 other other JJ cord-015021-pol2qm74 7805 25 than than IN cord-015021-pol2qm74 7805 26 Gram gram NN cord-015021-pol2qm74 7805 27 - - HYPH cord-015021-pol2qm74 7805 28 negative negative JJ cord-015021-pol2qm74 7805 29 bacteria bacteria NNS cord-015021-pol2qm74 7805 30 . . . cord-015021-pol2qm74 7806 1 Evidence evidence NN cord-015021-pol2qm74 7806 2 has have VBZ cord-015021-pol2qm74 7806 3 begun begin VBN cord-015021-pol2qm74 7806 4 to to TO cord-015021-pol2qm74 7806 5 accumulate accumulate VB cord-015021-pol2qm74 7806 6 which which WDT cord-015021-pol2qm74 7806 7 suggests suggest VBZ cord-015021-pol2qm74 7806 8 that that IN cord-015021-pol2qm74 7806 9 in in IN cord-015021-pol2qm74 7806 10 sepsis sepsis NN cord-015021-pol2qm74 7806 11 excess excess JJ cord-015021-pol2qm74 7806 12 production production NN cord-015021-pol2qm74 7806 13 of of IN cord-015021-pol2qm74 7806 14 LPS lp NNS cord-015021-pol2qm74 7806 15 and and CC cord-015021-pol2qm74 7806 16 cytokines cytokine NNS cord-015021-pol2qm74 7806 17 can can MD cord-015021-pol2qm74 7806 18 lead lead VB cord-015021-pol2qm74 7806 19 to to IN cord-015021-pol2qm74 7806 20 uncontrolled uncontrolled JJ cord-015021-pol2qm74 7806 21 production production NN cord-015021-pol2qm74 7806 22 of of IN cord-015021-pol2qm74 7806 23 iNOS inos NN cord-015021-pol2qm74 7806 24 and and CC cord-015021-pol2qm74 7806 25 that that IN cord-015021-pol2qm74 7806 26 this this DT cord-015021-pol2qm74 7806 27 might may MD cord-015021-pol2qm74 7806 28 in in IN cord-015021-pol2qm74 7806 29 part part NN cord-015021-pol2qm74 7806 30 explain explain VB cord-015021-pol2qm74 7806 31 the the DT cord-015021-pol2qm74 7806 32 severe severe JJ cord-015021-pol2qm74 7806 33 unresponsive unresponsive JJ cord-015021-pol2qm74 7806 34 hypotension hypotension NN cord-015021-pol2qm74 7806 35 seen see VBN cord-015021-pol2qm74 7806 36 in in IN cord-015021-pol2qm74 7806 37 some some DT cord-015021-pol2qm74 7806 38 septic septic JJ cord-015021-pol2qm74 7806 39 patients patient NNS cord-015021-pol2qm74 7806 40 . . . cord-015021-pol2qm74 7807 1 A a DT cord-015021-pol2qm74 7807 2 number number NN cord-015021-pol2qm74 7807 3 of of IN cord-015021-pol2qm74 7807 4 strategies strategy NNS cord-015021-pol2qm74 7807 5 have have VBP cord-015021-pol2qm74 7807 6 been be VBN cord-015021-pol2qm74 7807 7 explored explore VBN cord-015021-pol2qm74 7807 8 in in IN cord-015021-pol2qm74 7807 9 an an DT cord-015021-pol2qm74 7807 10 attempt attempt NN cord-015021-pol2qm74 7807 11 to to TO cord-015021-pol2qm74 7807 12 limit limit VB cord-015021-pol2qm74 7807 13 excess excess JJ cord-015021-pol2qm74 7807 14 NO no DT cord-015021-pol2qm74 7807 15 production production NN cord-015021-pol2qm74 7807 16 . . . cord-015021-pol2qm74 7808 1 A a DT cord-015021-pol2qm74 7808 2 favourite favourite JJ cord-015021-pol2qm74 7808 3 target target NN cord-015021-pol2qm74 7808 4 has have VBZ cord-015021-pol2qm74 7808 5 been be VBN cord-015021-pol2qm74 7808 6 competitive competitive JJ cord-015021-pol2qm74 7808 7 inhibition inhibition NN cord-015021-pol2qm74 7808 8 of of IN cord-015021-pol2qm74 7808 9 NOS NOS NNP cord-015021-pol2qm74 7808 10 by by IN cord-015021-pol2qm74 7808 11 arginine arginine NN cord-015021-pol2qm74 7808 12 analogues analogue NNS cord-015021-pol2qm74 7808 13 such such JJ cord-015021-pol2qm74 7808 14 as as IN cord-015021-pol2qm74 7808 15 L L NNP cord-015021-pol2qm74 7808 16 - - HYPH cord-015021-pol2qm74 7808 17 NMMA NMMA NNP cord-015021-pol2qm74 7808 18 . . . cord-015021-pol2qm74 7809 1 In in IN cord-015021-pol2qm74 7809 2 animals animal NNS cord-015021-pol2qm74 7809 3 , , , cord-015021-pol2qm74 7809 4 some some DT cord-015021-pol2qm74 7809 5 investigators investigator NNS cord-015021-pol2qm74 7809 6 have have VBP cord-015021-pol2qm74 7809 7 shown show VBN cord-015021-pol2qm74 7809 8 that that IN cord-015021-pol2qm74 7809 9 the the DT cord-015021-pol2qm74 7809 10 haemodynamic haemodynamic JJ cord-015021-pol2qm74 7809 11 effects effect NNS cord-015021-pol2qm74 7809 12 of of IN cord-015021-pol2qm74 7809 13 LPS LPS NNP cord-015021-pol2qm74 7809 14 challenge challenge NN cord-015021-pol2qm74 7809 15 can can MD cord-015021-pol2qm74 7809 16 be be VB cord-015021-pol2qm74 7809 17 attenuated attenuate VBN cord-015021-pol2qm74 7809 18 by by IN cord-015021-pol2qm74 7809 19 L L NNP cord-015021-pol2qm74 7809 20 - - HYPH cord-015021-pol2qm74 7809 21 NMMA NMMA NNP cord-015021-pol2qm74 7809 22 , , , cord-015021-pol2qm74 7809 23 but but CC cord-015021-pol2qm74 7809 24 there there EX cord-015021-pol2qm74 7809 25 is be VBZ cord-015021-pol2qm74 7809 26 a a DT cord-015021-pol2qm74 7809 27 narrow narrow JJ cord-015021-pol2qm74 7809 28 toxic toxic JJ cord-015021-pol2qm74 7809 29 - - HYPH cord-015021-pol2qm74 7809 30 therapeutic therapeutic JJ cord-015021-pol2qm74 7809 31 ratio ratio NN cord-015021-pol2qm74 7809 32 . . . cord-015021-pol2qm74 7810 1 In in IN cord-015021-pol2qm74 7810 2 a a DT cord-015021-pol2qm74 7810 3 model model NN cord-015021-pol2qm74 7810 4 of of IN cord-015021-pol2qm74 7810 5 live live JJ cord-015021-pol2qm74 7810 6 E. E. NNP cord-015021-pol2qm74 7810 7 cell cell NN cord-015021-pol2qm74 7810 8 sepsis sepsis NN cord-015021-pol2qm74 7810 9 , , , cord-015021-pol2qm74 7810 10 we -PRON- PRP cord-015021-pol2qm74 7810 11 have have VBP cord-015021-pol2qm74 7810 12 been be VBN cord-015021-pol2qm74 7810 13 unable unable JJ cord-015021-pol2qm74 7810 14 to to TO cord-015021-pol2qm74 7810 15 reproduce reproduce VB cord-015021-pol2qm74 7810 16 these these DT cord-015021-pol2qm74 7810 17 findings finding NNS cord-015021-pol2qm74 7810 18 . . . cord-015021-pol2qm74 7811 1 Localisation localisation NN cord-015021-pol2qm74 7811 2 of of IN cord-015021-pol2qm74 7811 3 NO no DT cord-015021-pol2qm74 7811 4 production production NN cord-015021-pol2qm74 7811 5 by by IN cord-015021-pol2qm74 7811 6 immunohistochemistry immunohistochemistry NN cord-015021-pol2qm74 7811 7 suggests suggest VBZ cord-015021-pol2qm74 7811 8 that that IN cord-015021-pol2qm74 7811 9 NO no DT cord-015021-pol2qm74 7811 10 production production NN cord-015021-pol2qm74 7811 11 is be VBZ cord-015021-pol2qm74 7811 12 compartmentalised compartmentalise VBN cord-015021-pol2qm74 7811 13 , , , cord-015021-pol2qm74 7811 14 and and CC cord-015021-pol2qm74 7811 15 more more RBR cord-015021-pol2qm74 7811 16 subtle subtle JJ cord-015021-pol2qm74 7811 17 methods method NNS cord-015021-pol2qm74 7811 18 of of IN cord-015021-pol2qm74 7811 19 regulation regulation NN cord-015021-pol2qm74 7811 20 may may MD cord-015021-pol2qm74 7811 21 be be VB cord-015021-pol2qm74 7811 22 required require VBN cord-015021-pol2qm74 7811 23 if if IN cord-015021-pol2qm74 7811 24 this this DT cord-015021-pol2qm74 7811 25 approach approach NN cord-015021-pol2qm74 7811 26 is be VBZ cord-015021-pol2qm74 7811 27 to to TO cord-015021-pol2qm74 7811 28 have have VB cord-015021-pol2qm74 7811 29 clinical clinical JJ cord-015021-pol2qm74 7811 30 valuc valuc NN cord-015021-pol2qm74 7811 31 . . . cord-015021-pol2qm74 7812 1 Anti anti JJ cord-015021-pol2qm74 7812 2 - - JJ cord-015021-pol2qm74 7812 3 adhesion adhesion NN cord-015021-pol2qm74 7812 4 molecule molecule NN cord-015021-pol2qm74 7812 5 strategies strategy NNS cord-015021-pol2qm74 7812 6 CH CH NNP cord-015021-pol2qm74 7812 7 Wortel Wortel NNP cord-015021-pol2qm74 7812 8 , , , cord-015021-pol2qm74 7812 9 Repligen Repligen NNP cord-015021-pol2qm74 7812 10 Corporation Corporation NNP cord-015021-pol2qm74 7812 11 , , , cord-015021-pol2qm74 7812 12 One one CD cord-015021-pol2qm74 7812 13 Kendall Kendall NNP cord-015021-pol2qm74 7812 14 Square Square NNP cord-015021-pol2qm74 7812 15 , , , cord-015021-pol2qm74 7812 16 Building Building NNP cord-015021-pol2qm74 7812 17 700 700 CD cord-015021-pol2qm74 7812 18 , , , cord-015021-pol2qm74 7812 19 Cambridge Cambridge NNP cord-015021-pol2qm74 7812 20 , , , cord-015021-pol2qm74 7812 21 MA MA NNP cord-015021-pol2qm74 7812 22 02139 02139 CD cord-015021-pol2qm74 7812 23 , , , cord-015021-pol2qm74 7812 24 USA USA NNP cord-015021-pol2qm74 7812 25 . . . cord-015021-pol2qm74 7813 1 The the DT cord-015021-pol2qm74 7813 2 neutrophil neutrophil NN cord-015021-pol2qm74 7813 3 has have VBZ cord-015021-pol2qm74 7813 4 been be VBN cord-015021-pol2qm74 7813 5 implicated implicate VBN cord-015021-pol2qm74 7813 6 as as IN cord-015021-pol2qm74 7813 7 a a DT cord-015021-pol2qm74 7813 8 pivotal pivotal JJ cord-015021-pol2qm74 7813 9 player player NN cord-015021-pol2qm74 7813 10 in in IN cord-015021-pol2qm74 7813 11 the the DT cord-015021-pol2qm74 7813 12 pathogenesis pathogenesis NN cord-015021-pol2qm74 7813 13 of of IN cord-015021-pol2qm74 7813 14 multiple multiple JJ cord-015021-pol2qm74 7813 15 organ organ NN cord-015021-pol2qm74 7813 16 dysfunction dysfunction NN cord-015021-pol2qm74 7813 17 . . . cord-015021-pol2qm74 7814 1 An an DT cord-015021-pol2qm74 7814 2 important important JJ cord-015021-pol2qm74 7814 3 first first JJ cord-015021-pol2qm74 7814 4 step step NN cord-015021-pol2qm74 7814 5 in in IN cord-015021-pol2qm74 7814 6 the the DT cord-015021-pol2qm74 7814 7 process process NN cord-015021-pol2qm74 7814 8 of of IN cord-015021-pol2qm74 7814 9 neutrophilmediated neutrophilmediated JJ cord-015021-pol2qm74 7814 10 organ organ NNP cord-015021-pol2qm74 7814 11 injury injury NN cord-015021-pol2qm74 7814 12 involves involve VBZ cord-015021-pol2qm74 7814 13 the the DT cord-015021-pol2qm74 7814 14 binding binding NN cord-015021-pol2qm74 7814 15 of of IN cord-015021-pol2qm74 7814 16 neutrophils neutrophil NNS cord-015021-pol2qm74 7814 17 to to IN cord-015021-pol2qm74 7814 18 endothelial endothelial JJ cord-015021-pol2qm74 7814 19 ceils ceil NNS cord-015021-pol2qm74 7814 20 . . . cord-015021-pol2qm74 7815 1 This this DT cord-015021-pol2qm74 7815 2 process process NN cord-015021-pol2qm74 7815 3 is be VBZ cord-015021-pol2qm74 7815 4 largely largely RB cord-015021-pol2qm74 7815 5 regulated regulate VBN cord-015021-pol2qm74 7815 6 by by IN cord-015021-pol2qm74 7815 7 complementary complementary JJ cord-015021-pol2qm74 7815 8 adhesion adhesion NN cord-015021-pol2qm74 7815 9 molecules molecule NNS cord-015021-pol2qm74 7815 10 , , , cord-015021-pol2qm74 7815 11 some some DT cord-015021-pol2qm74 7815 12 of of IN cord-015021-pol2qm74 7815 13 which which WDT cord-015021-pol2qm74 7815 14 are be VBP cord-015021-pol2qm74 7815 15 present present JJ cord-015021-pol2qm74 7815 16 constitutively constitutively RB cord-015021-pol2qm74 7815 17 on on IN cord-015021-pol2qm74 7815 18 the the DT cord-015021-pol2qm74 7815 19 cell cell NN cord-015021-pol2qm74 7815 20 surface surface NN cord-015021-pol2qm74 7815 21 and and CC cord-015021-pol2qm74 7815 22 others other NNS cord-015021-pol2qm74 7815 23 that that WDT cord-015021-pol2qm74 7815 24 can can MD cord-015021-pol2qm74 7815 25 be be VB cord-015021-pol2qm74 7815 26 upregulated upregulate VBN cord-015021-pol2qm74 7815 27 in in IN cord-015021-pol2qm74 7815 28 response response NN cord-015021-pol2qm74 7815 29 to to IN cord-015021-pol2qm74 7815 30 chemotactic chemotactic JJ cord-015021-pol2qm74 7815 31 and and CC cord-015021-pol2qm74 7815 32 pro pro JJ cord-015021-pol2qm74 7815 33 - - JJ cord-015021-pol2qm74 7815 34 inflammatory inflammatory JJ cord-015021-pol2qm74 7815 35 stimuli stimulus NNS cord-015021-pol2qm74 7815 36 . . . cord-015021-pol2qm74 7816 1 Several several JJ cord-015021-pol2qm74 7816 2 different different JJ cord-015021-pol2qm74 7816 3 adhesion adhesion NN cord-015021-pol2qm74 7816 4 molecules molecule NNS cord-015021-pol2qm74 7816 5 have have VBP cord-015021-pol2qm74 7816 6 been be VBN cord-015021-pol2qm74 7816 7 described describe VBN cord-015021-pol2qm74 7816 8 . . . cord-015021-pol2qm74 7817 1 L L NNP cord-015021-pol2qm74 7817 2 - - HYPH cord-015021-pol2qm74 7817 3 selec selec NNP cord-015021-pol2qm74 7817 4 tin tin NN cord-015021-pol2qm74 7817 5 is be VBZ cord-015021-pol2qm74 7817 6 expressed express VBN cord-015021-pol2qm74 7817 7 on on IN cord-015021-pol2qm74 7817 8 the the DT cord-015021-pol2qm74 7817 9 plasma plasma NN cord-015021-pol2qm74 7817 10 membrane membrane NN cord-015021-pol2qm74 7817 11 of of IN cord-015021-pol2qm74 7817 12 neutrophils neutrophil NNS cord-015021-pol2qm74 7817 13 and and CC cord-015021-pol2qm74 7817 14 is be VBZ cord-015021-pol2qm74 7817 15 shed shed VBN cord-015021-pol2qm74 7817 16 from from IN cord-015021-pol2qm74 7817 17 the the DT cord-015021-pol2qm74 7817 18 surface surface NN cord-015021-pol2qm74 7817 19 early early RB cord-015021-pol2qm74 7817 20 in in IN cord-015021-pol2qm74 7817 21 the the DT cord-015021-pol2qm74 7817 22 inflammatory inflammatory JJ cord-015021-pol2qm74 7817 23 process process NN cord-015021-pol2qm74 7817 24 . . . cord-015021-pol2qm74 7818 1 It -PRON- PRP cord-015021-pol2qm74 7818 2 is be VBZ cord-015021-pol2qm74 7818 3 therefore therefore RB cord-015021-pol2qm74 7818 4 thought think VBN cord-015021-pol2qm74 7818 5 to to TO cord-015021-pol2qm74 7818 6 mediate mediate VB cord-015021-pol2qm74 7818 7 the the DT cord-015021-pol2qm74 7818 8 initial initial JJ cord-015021-pol2qm74 7818 9 interactions interaction NNS cord-015021-pol2qm74 7818 10 with with IN cord-015021-pol2qm74 7818 11 endothelial endothelial JJ cord-015021-pol2qm74 7818 12 cells cell NNS cord-015021-pol2qm74 7818 13 . . . cord-015021-pol2qm74 7819 1 E e LS cord-015021-pol2qm74 7819 2 - - NN cord-015021-pol2qm74 7819 3 selectin selectin NN cord-015021-pol2qm74 7819 4 and and CC cord-015021-pol2qm74 7819 5 P p NN cord-015021-pol2qm74 7819 6 - - HYPH cord-015021-pol2qm74 7819 7 selectin selectin NNP cord-015021-pol2qm74 7819 8 are be VBP cord-015021-pol2qm74 7819 9 endothelial endothelial JJ cord-015021-pol2qm74 7819 10 adhesion adhesion NN cord-015021-pol2qm74 7819 11 molecules molecule NNS cord-015021-pol2qm74 7819 12 . . . cord-015021-pol2qm74 7820 1 E E NNP cord-015021-pol2qm74 7820 2 - - NN cord-015021-pol2qm74 7820 3 selectin selectin NNP cord-015021-pol2qm74 7820 4 is be VBZ cord-015021-pol2qm74 7820 5 not not RB cord-015021-pol2qm74 7820 6 constitutively constitutively RB cord-015021-pol2qm74 7820 7 expressed express VBN cord-015021-pol2qm74 7820 8 but but CC cord-015021-pol2qm74 7820 9 is be VBZ cord-015021-pol2qm74 7820 10 upregulated upregulate VBN cord-015021-pol2qm74 7820 11 by by IN cord-015021-pol2qm74 7820 12 inflammatory inflammatory JJ cord-015021-pol2qm74 7820 13 mediators mediator NNS cord-015021-pol2qm74 7820 14 , , , cord-015021-pol2qm74 7820 15 particularly particularly RB cord-015021-pol2qm74 7820 16 IL-1 IL-1 NNP cord-015021-pol2qm74 7820 17 and and CC cord-015021-pol2qm74 7820 18 TNF TNF NNP cord-015021-pol2qm74 7820 19 . . . cord-015021-pol2qm74 7821 1 P p NN cord-015021-pol2qm74 7821 2 - - HYPH cord-015021-pol2qm74 7821 3 selectin selectin NNP cord-015021-pol2qm74 7821 4 is be VBZ cord-015021-pol2qm74 7821 5 present present JJ cord-015021-pol2qm74 7821 6 in in IN cord-015021-pol2qm74 7821 7 the the DT cord-015021-pol2qm74 7821 8 Weibel Weibel NNP cord-015021-pol2qm74 7821 9 - - HYPH cord-015021-pol2qm74 7821 10 Palade Palade NNP cord-015021-pol2qm74 7821 11 bodies body NNS cord-015021-pol2qm74 7821 12 within within IN cord-015021-pol2qm74 7821 13 the the DT cord-015021-pol2qm74 7821 14 endothelial endothelial JJ cord-015021-pol2qm74 7821 15 cytoplasm cytoplasm NN cord-015021-pol2qm74 7821 16 and and CC cord-015021-pol2qm74 7821 17 can can MD cord-015021-pol2qm74 7821 18 be be VB cord-015021-pol2qm74 7821 19 upregulated upregulate VBN cord-015021-pol2qm74 7821 20 rapidly rapidly RB cord-015021-pol2qm74 7821 21 in in IN cord-015021-pol2qm74 7821 22 response response NN cord-015021-pol2qm74 7821 23 to to IN cord-015021-pol2qm74 7821 24 thrombin thrombin NN cord-015021-pol2qm74 7821 25 , , , cord-015021-pol2qm74 7821 26 histamine histamine NN cord-015021-pol2qm74 7821 27 , , , cord-015021-pol2qm74 7821 28 and and CC cord-015021-pol2qm74 7821 29 oxidants oxidant NNS cord-015021-pol2qm74 7821 30 . . . cord-015021-pol2qm74 7822 1 All all DT cord-015021-pol2qm74 7822 2 selectins selectin NNS cord-015021-pol2qm74 7822 3 recognize recognize VBP cord-015021-pol2qm74 7822 4 oligosaccharides oligosaccharide NNS cord-015021-pol2qm74 7822 5 , , , cord-015021-pol2qm74 7822 6 particularly particularly RB cord-015021-pol2qm74 7822 7 sialylated sialylate VBN cord-015021-pol2qm74 7822 8 Lewis Lewis NNP cord-015021-pol2qm74 7822 9 X X NNP cord-015021-pol2qm74 7822 10 antigen antigen NN cord-015021-pol2qm74 7822 11 . . . cord-015021-pol2qm74 7823 1 This this DT cord-015021-pol2qm74 7823 2 carbohydrate carbohydrate NN cord-015021-pol2qm74 7823 3 moiety moiety NN cord-015021-pol2qm74 7823 4 is be VBZ cord-015021-pol2qm74 7823 5 expressed express VBN cord-015021-pol2qm74 7823 6 on on IN cord-015021-pol2qm74 7823 7 many many JJ cord-015021-pol2qm74 7823 8 proteins protein NNS cord-015021-pol2qm74 7823 9 , , , cord-015021-pol2qm74 7823 10 including include VBG cord-015021-pol2qm74 7823 11 the the DT cord-015021-pol2qm74 7823 12 selectins selectin NNS cord-015021-pol2qm74 7823 13 themselves -PRON- PRP cord-015021-pol2qm74 7823 14 . . . cord-015021-pol2qm74 7824 1 The the DT cord-015021-pol2qm74 7824 2 leukocyte leukocyte NN cord-015021-pol2qm74 7824 3 integrins integrin NNS cord-015021-pol2qm74 7824 4 are be VBP cord-015021-pol2qm74 7824 5 glycoproteins glycoprotein NNS cord-015021-pol2qm74 7824 6 expressed express VBN cord-015021-pol2qm74 7824 7 on on IN cord-015021-pol2qm74 7824 8 the the DT cord-015021-pol2qm74 7824 9 neutrophil neutrophil NN cord-015021-pol2qm74 7824 10 surface surface NN cord-015021-pol2qm74 7824 11 and and CC cord-015021-pol2qm74 7824 12 in in IN cord-015021-pol2qm74 7824 13 the the DT cord-015021-pol2qm74 7824 14 cytoplasmic cytoplasmic JJ cord-015021-pol2qm74 7824 15 granules granule NNS cord-015021-pol2qm74 7824 16 . . . cord-015021-pol2qm74 7825 1 Integrins integrin NNS cord-015021-pol2qm74 7825 2 consist consist VBP cord-015021-pol2qm74 7825 3 of of IN cord-015021-pol2qm74 7825 4 a a DT cord-015021-pol2qm74 7825 5 common common JJ cord-015021-pol2qm74 7825 6 beta2 beta2 NN cord-015021-pol2qm74 7825 7 or or CC cord-015021-pol2qm74 7825 8 cluster cluster NN cord-015021-pol2qm74 7825 9 differentiation differentiation NN cord-015021-pol2qm74 7825 10 ( ( -LRB- cord-015021-pol2qm74 7825 11 CD)I CD)I NNP cord-015021-pol2qm74 7825 12 8 8 CD cord-015021-pol2qm74 7825 13 chain chain NN cord-015021-pol2qm74 7825 14 covalently covalently RB cord-015021-pol2qm74 7825 15 linked link VBN cord-015021-pol2qm74 7825 16 to to IN cord-015021-pol2qm74 7825 17 one one CD cord-015021-pol2qm74 7825 18 of of IN cord-015021-pol2qm74 7825 19 three three CD cord-015021-pol2qm74 7825 20 different different JJ cord-015021-pol2qm74 7825 21 alpha alpha NN cord-015021-pol2qm74 7825 22 chains chain NNS cord-015021-pol2qm74 7825 23 ( ( -LRB- cord-015021-pol2qm74 7825 24 CD11 CD11 NNP cord-015021-pol2qm74 7825 25 a a DT cord-015021-pol2qm74 7825 26 , , , cord-015021-pol2qm74 7825 27 CD1 CD1 NNP cord-015021-pol2qm74 7825 28 lb lb NNP cord-015021-pol2qm74 7825 29 , , , cord-015021-pol2qm74 7825 30 CD1 CD1 NNP cord-015021-pol2qm74 7825 31 lc lc NNP cord-015021-pol2qm74 7825 32 ) ) -RRB- cord-015021-pol2qm74 7825 33 and and CC cord-015021-pol2qm74 7825 34 exist exist VBP cord-015021-pol2qm74 7825 35 on on IN cord-015021-pol2qm74 7825 36 the the DT cord-015021-pol2qm74 7825 37 cell cell NN cord-015021-pol2qm74 7825 38 surface surface NN cord-015021-pol2qm74 7825 39 as as IN cord-015021-pol2qm74 7825 40 three three CD cord-015021-pol2qm74 7825 41 distinct distinct JJ cord-015021-pol2qm74 7825 42 heterodimers heterodimer NNS cord-015021-pol2qm74 7825 43 . . . cord-015021-pol2qm74 7826 1 CD1 CD1 NNP cord-015021-pol2qm74 7826 2 l l NNP cord-015021-pol2qm74 7826 3 a a NNP cord-015021-pol2qm74 7826 4 / / SYM cord-015021-pol2qm74 7826 5 CDI CDI NNP cord-015021-pol2qm74 7826 6 8 8 CD cord-015021-pol2qm74 7826 7 is be VBZ cord-015021-pol2qm74 7826 8 expressed express VBN cord-015021-pol2qm74 7826 9 on on IN cord-015021-pol2qm74 7826 10 all all DT cord-015021-pol2qm74 7826 11 leukocytes leukocyte NNS cord-015021-pol2qm74 7826 12 , , , cord-015021-pol2qm74 7826 13 whereas whereas IN cord-015021-pol2qm74 7826 14 CD1 CD1 NNP cord-015021-pol2qm74 7826 15 l l NNP cord-015021-pol2qm74 7826 16 b/ b/ NN cord-015021-pol2qm74 7826 17 CD18 CD18 NNP cord-015021-pol2qm74 7826 18 and and CC cord-015021-pol2qm74 7826 19 CD1 CD1 NNP cord-015021-pol2qm74 7826 20 lc lc NNP cord-015021-pol2qm74 7826 21 / / SYM cord-015021-pol2qm74 7826 22 CD18 CD18 NNP cord-015021-pol2qm74 7826 23 are be VBP cord-015021-pol2qm74 7826 24 restricted restrict VBN cord-015021-pol2qm74 7826 25 to to IN cord-015021-pol2qm74 7826 26 cells cell NNS cord-015021-pol2qm74 7826 27 of of IN cord-015021-pol2qm74 7826 28 myeloid myeloid JJ cord-015021-pol2qm74 7826 29 origin origin NN cord-015021-pol2qm74 7826 30 . . . cord-015021-pol2qm74 7827 1 CD1 CD1 NNP cord-015021-pol2qm74 7827 2 I I NNP cord-015021-pol2qm74 7827 3 / / SYM cord-015021-pol2qm74 7827 4 CD18 CD18 NNP cord-015021-pol2qm74 7827 5 interacts interact VBZ cord-015021-pol2qm74 7827 6 with with IN cord-015021-pol2qm74 7827 7 intracellular intracellular JJ cord-015021-pol2qm74 7827 8 adhesion adhesion NN cord-015021-pol2qm74 7827 9 molecule-1 molecule-1 NN cord-015021-pol2qm74 7827 10 ( ( -LRB- cord-015021-pol2qm74 7827 11 ICAM-1 ICAM-1 NNP cord-015021-pol2qm74 7827 12 ) ) -RRB- cord-015021-pol2qm74 7827 13 , , , cord-015021-pol2qm74 7827 14 its -PRON- PRP$ cord-015021-pol2qm74 7827 15 ligand ligand NN cord-015021-pol2qm74 7827 16 on on IN cord-015021-pol2qm74 7827 17 endothelial endothelial JJ cord-015021-pol2qm74 7827 18 cells cell NNS cord-015021-pol2qm74 7827 19 . . . cord-015021-pol2qm74 7828 1 ICAM-1 ICAM-1 NNP cord-015021-pol2qm74 7828 2 is be VBZ cord-015021-pol2qm74 7828 3 a a DT cord-015021-pol2qm74 7828 4 member member NN cord-015021-pol2qm74 7828 5 of of IN cord-015021-pol2qm74 7828 6 the the DT cord-015021-pol2qm74 7828 7 immunoglobulin immunoglobulin NN cord-015021-pol2qm74 7828 8 family family NN cord-015021-pol2qm74 7828 9 of of IN cord-015021-pol2qm74 7828 10 adhesion adhesion NN cord-015021-pol2qm74 7828 11 molecules molecule NNS cord-015021-pol2qm74 7828 12 . . . cord-015021-pol2qm74 7829 1 It -PRON- PRP cord-015021-pol2qm74 7829 2 is be VBZ cord-015021-pol2qm74 7829 3 constitutively constitutively RB cord-015021-pol2qm74 7829 4 expressed express VBN cord-015021-pol2qm74 7829 5 on on IN cord-015021-pol2qm74 7829 6 endothelial endothelial JJ cord-015021-pol2qm74 7829 7 cells cell NNS cord-015021-pol2qm74 7829 8 and and CC cord-015021-pol2qm74 7829 9 can can MD cord-015021-pol2qm74 7829 10 be be VB cord-015021-pol2qm74 7829 11 upregulated upregulate VBN cord-015021-pol2qm74 7829 12 by by IN cord-015021-pol2qm74 7829 13 cytokines cytokine NNS cord-015021-pol2qm74 7829 14 . . . cord-015021-pol2qm74 7830 1 The the DT cord-015021-pol2qm74 7830 2 potential potential NN cord-015021-pol2qm74 7830 3 for for IN cord-015021-pol2qm74 7830 4 monoclonal monoclonal JJ cord-015021-pol2qm74 7830 5 antibodies antibody NNS cord-015021-pol2qm74 7830 6 to to TO cord-015021-pol2qm74 7830 7 adhesion adhesion NN cord-015021-pol2qm74 7830 8 proteins protein NNS cord-015021-pol2qm74 7830 9 to to TO cord-015021-pol2qm74 7830 10 reduce reduce VB cord-015021-pol2qm74 7830 11 vascular vascular JJ cord-015021-pol2qm74 7830 12 and and CC cord-015021-pol2qm74 7830 13 tissue tissue NN cord-015021-pol2qm74 7830 14 damage damage NN cord-015021-pol2qm74 7830 15 has have VBZ cord-015021-pol2qm74 7830 16 been be VBN cord-015021-pol2qm74 7830 17 studied study VBN cord-015021-pol2qm74 7830 18 in in IN cord-015021-pol2qm74 7830 19 alarge alarge NN cord-015021-pol2qm74 7830 20 number number NN cord-015021-pol2qm74 7830 21 of of IN cord-015021-pol2qm74 7830 22 experimental experimental JJ cord-015021-pol2qm74 7830 23 models model NNS cord-015021-pol2qm74 7830 24 . . . cord-015021-pol2qm74 7831 1 Protective protective JJ cord-015021-pol2qm74 7831 2 effects effect NNS cord-015021-pol2qm74 7831 3 have have VBP cord-015021-pol2qm74 7831 4 been be VBN cord-015021-pol2qm74 7831 5 observed observe VBN cord-015021-pol2qm74 7831 6 in in IN cord-015021-pol2qm74 7831 7 a a DT cord-015021-pol2qm74 7831 8 wide wide JJ cord-015021-pol2qm74 7831 9 variety variety NN cord-015021-pol2qm74 7831 10 of of IN cord-015021-pol2qm74 7831 11 inflammatory inflammatory JJ cord-015021-pol2qm74 7831 12 , , , cord-015021-pol2qm74 7831 13 immune immune JJ cord-015021-pol2qm74 7831 14 , , , cord-015021-pol2qm74 7831 15 and and CC cord-015021-pol2qm74 7831 16 ischemia ischemia NN cord-015021-pol2qm74 7831 17 - - HYPH cord-015021-pol2qm74 7831 18 reperfusion reperfusion NN cord-015021-pol2qm74 7831 19 injuries injury NNS cord-015021-pol2qm74 7831 20 such such JJ cord-015021-pol2qm74 7831 21 as as IN cord-015021-pol2qm74 7831 22 arthritis arthritis NN cord-015021-pol2qm74 7831 23 , , , cord-015021-pol2qm74 7831 24 bums bum NNS cord-015021-pol2qm74 7831 25 , , , cord-015021-pol2qm74 7831 26 endotoxic endotoxic JJ cord-015021-pol2qm74 7831 27 shock shock NN cord-015021-pol2qm74 7831 28 , , , cord-015021-pol2qm74 7831 29 bacterial bacterial JJ cord-015021-pol2qm74 7831 30 meningitis meningitis NN cord-015021-pol2qm74 7831 31 , , , cord-015021-pol2qm74 7831 32 autoimmune autoimmune JJ cord-015021-pol2qm74 7831 33 diabetes diabetes NN cord-015021-pol2qm74 7831 34 , , , cord-015021-pol2qm74 7831 35 nerve nerve JJ cord-015021-pol2qm74 7831 36 degeneration degeneration NN cord-015021-pol2qm74 7831 37 , , , cord-015021-pol2qm74 7831 38 allograft allograft NN cord-015021-pol2qm74 7831 39 rejection rejection NN cord-015021-pol2qm74 7831 40 , , , cord-015021-pol2qm74 7831 41 allergic allergic JJ cord-015021-pol2qm74 7831 42 asthma asthma NN cord-015021-pol2qm74 7831 43 , , , cord-015021-pol2qm74 7831 44 acute acute JJ cord-015021-pol2qm74 7831 45 lung lung NN cord-015021-pol2qm74 7831 46 inflammation inflammation NN cord-015021-pol2qm74 7831 47 , , , cord-015021-pol2qm74 7831 48 skin skin NN cord-015021-pol2qm74 7831 49 lesions lesion NNS cord-015021-pol2qm74 7831 50 , , , cord-015021-pol2qm74 7831 51 and and CC cord-015021-pol2qm74 7831 52 ischemia ischemia NN cord-015021-pol2qm74 7831 53 - - HYPH cord-015021-pol2qm74 7831 54 reperfusion reperfusion NN cord-015021-pol2qm74 7831 55 models model NNS cord-015021-pol2qm74 7831 56 of of IN cord-015021-pol2qm74 7831 57 the the DT cord-015021-pol2qm74 7831 58 intestine intestine NN cord-015021-pol2qm74 7831 59 , , , cord-015021-pol2qm74 7831 60 myocardium myocardium NN cord-015021-pol2qm74 7831 61 , , , cord-015021-pol2qm74 7831 62 lung lung NN cord-015021-pol2qm74 7831 63 , , , cord-015021-pol2qm74 7831 64 skeletal skeletal JJ cord-015021-pol2qm74 7831 65 muscle muscle NN cord-015021-pol2qm74 7831 66 , , , cord-015021-pol2qm74 7831 67 and and CC cord-015021-pol2qm74 7831 68 central central JJ cord-015021-pol2qm74 7831 69 nervous nervous JJ cord-015021-pol2qm74 7831 70 system system NN cord-015021-pol2qm74 7831 71 . . . cord-015021-pol2qm74 7832 1 Protective protective JJ cord-015021-pol2qm74 7832 2 effects effect NNS cord-015021-pol2qm74 7832 3 have have VBP cord-015021-pol2qm74 7832 4 also also RB cord-015021-pol2qm74 7832 5 been be VBN cord-015021-pol2qm74 7832 6 observed observe VBN cord-015021-pol2qm74 7832 7 in in IN cord-015021-pol2qm74 7832 8 animals animal NNS cord-015021-pol2qm74 7832 9 resuscitated resuscitate VBD cord-015021-pol2qm74 7832 10 following follow VBG cord-015021-pol2qm74 7832 11 hemorrhagic hemorrhagic JJ cord-015021-pol2qm74 7832 12 shock shock NN cord-015021-pol2qm74 7832 13 . . . cord-015021-pol2qm74 7833 1 Since since IN cord-015021-pol2qm74 7833 2 modulating modulate VBG cord-015021-pol2qm74 7833 3 the the DT cord-015021-pol2qm74 7833 4 function function NN cord-015021-pol2qm74 7833 5 of of IN cord-015021-pol2qm74 7833 6 adhesion adhesion NN cord-015021-pol2qm74 7833 7 molecules molecule NNS cord-015021-pol2qm74 7833 8 may may MD cord-015021-pol2qm74 7833 9 temporarily temporarily RB cord-015021-pol2qm74 7833 10 leave leave VB cord-015021-pol2qm74 7833 11 the the DT cord-015021-pol2qm74 7833 12 host host NN cord-015021-pol2qm74 7833 13 without without IN cord-015021-pol2qm74 7833 14 effective effective JJ cord-015021-pol2qm74 7833 15 defense defense NN cord-015021-pol2qm74 7833 16 machinery machinery NN cord-015021-pol2qm74 7833 17 , , , cord-015021-pol2qm74 7833 18 safety safety NN cord-015021-pol2qm74 7833 19 evaluations evaluation NNS cord-015021-pol2qm74 7833 20 are be VBP cord-015021-pol2qm74 7833 21 of of IN cord-015021-pol2qm74 7833 22 utmost utmost JJ cord-015021-pol2qm74 7833 23 importance importance NN cord-015021-pol2qm74 7833 24 in in IN cord-015021-pol2qm74 7833 25 evaluating evaluate VBG cord-015021-pol2qm74 7833 26 this this DT cord-015021-pol2qm74 7833 27 therapeutic therapeutic JJ cord-015021-pol2qm74 7833 28 approach approach NN cord-015021-pol2qm74 7833 29 . . . cord-015021-pol2qm74 7834 1 Treatment treatment NN cord-015021-pol2qm74 7834 2 of of IN cord-015021-pol2qm74 7834 3 Gram gram NN cord-015021-pol2qm74 7834 4 - - HYPH cord-015021-pol2qm74 7834 5 negative negative JJ cord-015021-pol2qm74 7834 6 septic septic JJ cord-015021-pol2qm74 7834 7 shock shock NN cord-015021-pol2qm74 7834 8 with with IN cord-015021-pol2qm74 7834 9 an an DT cord-015021-pol2qm74 7834 10 immunoglobulin immunoglobulin NN cord-015021-pol2qm74 7834 11 preparation preparation NN cord-015021-pol2qm74 7834 12 : : : cord-015021-pol2qm74 7835 1 A a DT cord-015021-pol2qm74 7835 2 prospective prospective JJ cord-015021-pol2qm74 7835 3 , , , cord-015021-pol2qm74 7835 4 randomized randomized JJ cord-015021-pol2qm74 7835 5 clinical clinical JJ cord-015021-pol2qm74 7835 6 trial trial NN cord-015021-pol2qm74 7835 7 INGOLF INGOLF NNP cord-015021-pol2qm74 7835 8 SCHEDEL SCHEDEL NNP cord-015021-pol2qm74 7835 9 , , , cord-015021-pol2qm74 7835 10 URSULA URSULA NNP cord-015021-pol2qm74 7835 11 DREIKHAUSEN DREIKHAUSEN NNP cord-015021-pol2qm74 7835 12 ; ; : cord-015021-pol2qm74 7835 13 BIRGIT BIRGIT NNP cord-015021-pol2qm74 7835 14 NENTWIG NENTWIG NNP cord-015021-pol2qm74 7835 15 ; ; : cord-015021-pol2qm74 7835 16 MARION MARION NNP cord-015021-pol2qm74 7835 17 HOCKENSCHNtEDER HOCKENSCHNtEDER NNP cord-015021-pol2qm74 7835 18 , , , cord-015021-pol2qm74 7835 19 DIRK DIRK NNP cord-015021-pol2qm74 7835 20 RAUTHMANN RAUTHMANN NNP cord-015021-pol2qm74 7835 21 , , , cord-015021-pol2qm74 7835 22 SALIM SALIM NNP cord-015021-pol2qm74 7835 23 BALIKCIOGLU BALIKCIOGLU NNP cord-015021-pol2qm74 7835 24 , , , cord-015021-pol2qm74 7835 25 ROLF ROLF NNP cord-015021-pol2qm74 7835 26 COLDEWEy COLDEWEy NNP cord-015021-pol2qm74 7835 27 , , , cord-015021-pol2qm74 7835 28 HELMUTH HELMUTH NNP cord-015021-pol2qm74 7835 29 DEICHER DEICHER NNP cord-015021-pol2qm74 7835 30 , , , cord-015021-pol2qm74 7835 31 MD MD NNP cord-015021-pol2qm74 7835 32 Endotoxin Endotoxin NNP cord-015021-pol2qm74 7835 33 may may MD cord-015021-pol2qm74 7835 34 play play VB cord-015021-pol2qm74 7835 35 a a DT cord-015021-pol2qm74 7835 36 major major JJ cord-015021-pol2qm74 7835 37 role role NN cord-015021-pol2qm74 7835 38 in in IN cord-015021-pol2qm74 7835 39 the the DT cord-015021-pol2qm74 7835 40 pathogenesls pathogenesls NN cord-015021-pol2qm74 7835 41 of of IN cord-015021-pol2qm74 7835 42 muitiorgan muitiorgan NNP cord-015021-pol2qm74 7835 43 failure failure NN cord-015021-pol2qm74 7835 44 in in IN cord-015021-pol2qm74 7835 45 the the DT cord-015021-pol2qm74 7835 46 context context NN cord-015021-pol2qm74 7835 47 of of IN cord-015021-pol2qm74 7835 48 the the DT cord-015021-pol2qm74 7835 49 toxic toxic JJ cord-015021-pol2qm74 7835 50 process process NN cord-015021-pol2qm74 7835 51 in in IN cord-015021-pol2qm74 7835 52 septicemia septicemia NN cord-015021-pol2qm74 7835 53 induced induce VBN cord-015021-pol2qm74 7835 54 by by IN cord-015021-pol2qm74 7835 55 gram gram NN cord-015021-pol2qm74 7835 56 - - HYPH cord-015021-pol2qm74 7835 57 negative negative JJ cord-015021-pol2qm74 7835 58 pathogens pathogen NNS cord-015021-pol2qm74 7835 59 . . . cord-015021-pol2qm74 7836 1 The the DT cord-015021-pol2qm74 7836 2 hypothesis hypothesis NN cord-015021-pol2qm74 7836 3 which which WDT cord-015021-pol2qm74 7836 4 has have VBZ cord-015021-pol2qm74 7836 5 led lead VBN cord-015021-pol2qm74 7836 6 to to IN cord-015021-pol2qm74 7836 7 a a DT cord-015021-pol2qm74 7836 8 prospective prospective JJ cord-015021-pol2qm74 7836 9 clinical clinical JJ cord-015021-pol2qm74 7836 10 study study NN cord-015021-pol2qm74 7836 11 consisted consist VBD cord-015021-pol2qm74 7836 12 in in IN cord-015021-pol2qm74 7836 13 the the DT cord-015021-pol2qm74 7836 14 idea idea NN cord-015021-pol2qm74 7836 15 of of IN cord-015021-pol2qm74 7836 16 inhibiting inhibit VBG cord-015021-pol2qm74 7836 17 the the DT cord-015021-pol2qm74 7836 18 biological biological JJ cord-015021-pol2qm74 7836 19 effects effect NNS cord-015021-pol2qm74 7836 20 ofendotoxin ofendotoxin RB cord-015021-pol2qm74 7836 21 during during IN cord-015021-pol2qm74 7836 22 the the DT cord-015021-pol2qm74 7836 23 early early JJ cord-015021-pol2qm74 7836 24 phase phase NN cord-015021-pol2qm74 7836 25 of of IN cord-015021-pol2qm74 7836 26 septic septic JJ cord-015021-pol2qm74 7836 27 process process NN cord-015021-pol2qm74 7836 28 , , , cord-015021-pol2qm74 7836 29 and and CC cord-015021-pol2qm74 7836 30 thereby thereby RB cord-015021-pol2qm74 7836 31 attampting attampte VBG cord-015021-pol2qm74 7836 32 to to TO cord-015021-pol2qm74 7836 33 attain attain VB cord-015021-pol2qm74 7836 34 a a DT cord-015021-pol2qm74 7836 35 positive positive JJ cord-015021-pol2qm74 7836 36 effect effect NN cord-015021-pol2qm74 7836 37 on on IN cord-015021-pol2qm74 7836 38 the the DT cord-015021-pol2qm74 7836 39 clinical clinical JJ cord-015021-pol2qm74 7836 40 course course NN cord-015021-pol2qm74 7836 41 of of IN cord-015021-pol2qm74 7836 42 the the DT cord-015021-pol2qm74 7836 43 disease disease NN cord-015021-pol2qm74 7836 44 . . . cord-015021-pol2qm74 7837 1 -Objecave -Objecave VBZ cord-015021-pol2qm74 7837 2 : : : cord-015021-pol2qm74 7837 3 To to TO cord-015021-pol2qm74 7837 4 evaluate evaluate VB cord-015021-pol2qm74 7837 5 the the DT cord-015021-pol2qm74 7837 6 effectiveness effectiveness NN cord-015021-pol2qm74 7837 7 ofa ofa NN cord-015021-pol2qm74 7837 8 polyclonal polyclonal JJ cord-015021-pol2qm74 7837 9 immunoglobulln immunoglobulln NN cord-015021-pol2qm74 7837 10 ( ( -LRB- cord-015021-pol2qm74 7837 11 Ig Ig NNP cord-015021-pol2qm74 7837 12 ) ) -RRB- cord-015021-pol2qm74 7837 13 preparation preparation NN cord-015021-pol2qm74 7837 14 containing contain VBG cord-015021-pol2qm74 7837 15 IgG IgG NNP cord-015021-pol2qm74 7837 16 , , , cord-015021-pol2qm74 7837 17 lgM lgM NNP cord-015021-pol2qm74 7837 18 , , , cord-015021-pol2qm74 7837 19 and and CC cord-015021-pol2qm74 7837 20 IgA IgA NNP cord-015021-pol2qm74 7837 21 as as IN cord-015021-pol2qm74 7837 22 an an DT cord-015021-pol2qm74 7837 23 adjunctive adjunctive JJ cord-015021-pol2qm74 7837 24 therapy therapy NN cord-015021-pol2qm74 7837 25 for for IN cord-015021-pol2qm74 7837 26 septic septic JJ cord-015021-pol2qm74 7837 27 shock shock NN cord-015021-pol2qm74 7837 28 . . . cord-015021-pol2qm74 7838 1 -Desigru -Desigru : cord-015021-pol2qm74 7838 2 Prospective prospective JJ cord-015021-pol2qm74 7838 3 , , , cord-015021-pol2qm74 7838 4 randomized randomized JJ cord-015021-pol2qm74 7838 5 clinical clinical JJ cord-015021-pol2qm74 7838 6 trial trial NN cord-015021-pol2qm74 7838 7 . . . cord-015021-pol2qm74 7839 1 Patients patient NNS cord-015021-pol2qm74 7839 2 : : : cord-015021-pol2qm74 7840 1 Fifty fifty CD cord-015021-pol2qm74 7840 2 - - HYPH cord-015021-pol2qm74 7840 3 five five CD cord-015021-pol2qm74 7840 4 patients patient NNS cord-015021-pol2qm74 7840 5 w w IN cord-015021-pol2qm74 7840 6 ~ ~ CD cord-015021-pol2qm74 7840 7 th th DT cord-015021-pol2qm74 7840 8 septic septic JJ cord-015021-pol2qm74 7840 9 shock shock NN cord-015021-pol2qm74 7840 10 were be VBD cord-015021-pol2qm74 7840 11 randomly randomly RB cord-015021-pol2qm74 7840 12 allocated allocate VBN cord-015021-pol2qm74 7840 13 to to IN cord-015021-pol2qm74 7840 14 two two CD cord-015021-pol2qm74 7840 15 groups group NNS cord-015021-pol2qm74 7840 16 according accord VBG cord-015021-pol2qm74 7840 17 to to IN cord-015021-pol2qm74 7840 18 criteria criterion NNS cord-015021-pol2qm74 7840 19 of of IN cord-015021-pol2qm74 7840 20 septic septic JJ cord-015021-pol2qm74 7840 21 shock shock NN cord-015021-pol2qm74 7840 22 . . . cord-015021-pol2qm74 7841 1 -Intervention -intervention NN cord-015021-pol2qm74 7841 2 : : : cord-015021-pol2qm74 7841 3 One one CD cord-015021-pol2qm74 7841 4 group group NN cord-015021-pol2qm74 7841 5 of of IN cord-015021-pol2qm74 7841 6 patients patient NNS cord-015021-pol2qm74 7841 7 ( ( -LRB- cord-015021-pol2qm74 7841 8 n n NN cord-015021-pol2qm74 7841 9 = = SYM cord-015021-pol2qm74 7841 10 27 27 CD cord-015021-pol2qm74 7841 11 ) ) -RRB- cord-015021-pol2qm74 7841 12 received receive VBD cord-015021-pol2qm74 7841 13 a a DT cord-015021-pol2qm74 7841 14 commercially commercially RB cord-015021-pol2qm74 7841 15 available available JJ cord-015021-pol2qm74 7841 16 immunoglobulin immunoglobulin NN cord-015021-pol2qm74 7841 17 preparation preparation NN cord-015021-pol2qm74 7841 18 ( ( -LRB- cord-015021-pol2qm74 7841 19 containing contain VBG cord-015021-pol2qm74 7841 20 high high JJ cord-015021-pol2qm74 7841 21 titers titer NNS cord-015021-pol2qm74 7841 22 of of IN cord-015021-pol2qm74 7841 23 antibodies antibody NNS cord-015021-pol2qm74 7841 24 specific specific JJ cord-015021-pol2qm74 7841 25 for for IN cord-015021-pol2qm74 7841 26 determinants determinant NNS cord-015021-pol2qm74 7841 27 to to IN cord-015021-pol2qm74 7841 28 bacteria1 bacteria1 NN cord-015021-pol2qm74 7841 29 endotoxin endotoxin NN cord-015021-pol2qm74 7841 30 ) ) -RRB- cord-015021-pol2qm74 7841 31 during during IN cord-015021-pol2qm74 7841 32 the the DT cord-015021-pol2qm74 7841 33 first first JJ cord-015021-pol2qm74 7841 34 3 3 CD cord-015021-pol2qm74 7841 35 days day NNS cord-015021-pol2qm74 7841 36 after after IN cord-015021-pol2qm74 7841 37 incIosion inciosion NN cord-015021-pol2qm74 7841 38 in in IN cord-015021-pol2qm74 7841 39 the the DT cord-015021-pol2qm74 7841 40 study study NN cord-015021-pol2qm74 7841 41 . . . cord-015021-pol2qm74 7842 1 The the DT cord-015021-pol2qm74 7842 2 other other JJ cord-015021-pol2qm74 7842 3 randomized randomized JJ cord-015021-pol2qm74 7842 4 group group NN cord-015021-pol2qm74 7842 5 ( ( -LRB- cord-015021-pol2qm74 7842 6 n n NN cord-015021-pol2qm74 7842 7 = = SYM cord-015021-pol2qm74 7842 8 28 28 CD cord-015021-pol2qm74 7842 9 ) ) -RRB- cord-015021-pol2qm74 7842 10 did do VBD cord-015021-pol2qm74 7842 11 not not RB cord-015021-pol2qm74 7842 12 receive receive VB cord-015021-pol2qm74 7842 13 any any DT cord-015021-pol2qm74 7842 14 immunogiobulin immunogiobulin NNP cord-015021-pol2qm74 7842 15 preparation preparation NN cord-015021-pol2qm74 7842 16 . . . cord-015021-pol2qm74 7843 1 -Measuremems -measuremem NNS cord-015021-pol2qm74 7844 1 and and CC cord-015021-pol2qm74 7844 2 Main Main NNP cord-015021-pol2qm74 7844 3 ResMts ResMts NNP cord-015021-pol2qm74 7844 4 : : : cord-015021-pol2qm74 7844 5 During during IN cord-015021-pol2qm74 7844 6 the the DT cord-015021-pol2qm74 7844 7 period period NN cord-015021-pol2qm74 7844 8 of of IN cord-015021-pol2qm74 7844 9 < < NNP cord-015021-pol2qm74 7844 10 6 6 CD cord-015021-pol2qm74 7844 11 wks wk NNS cord-015021-pol2qm74 7844 12 after after IN cord-015021-pol2qm74 7844 13 the the DT cord-015021-pol2qm74 7844 14 beginning beginning NN cord-015021-pol2qm74 7844 15 of of IN cord-015021-pol2qm74 7844 16 clinically clinically RB cord-015021-pol2qm74 7844 17 apparent apparent JJ cord-015021-pol2qm74 7844 18 septic septic JJ cord-015021-pol2qm74 7844 19 shock shock NN cord-015021-pol2qm74 7844 20 , , , cord-015021-pol2qm74 7844 21 death death NN cord-015021-pol2qm74 7844 22 related relate VBN cord-015021-pol2qm74 7844 23 to to IN cord-015021-pol2qm74 7844 24 the the DT cord-015021-pol2qm74 7844 25 septic septic JJ cord-015021-pol2qm74 7844 26 process process NN cord-015021-pol2qm74 7844 27 occurred occur VBD cord-015021-pol2qm74 7844 28 in in IN cord-015021-pol2qm74 7844 29 one one CD cord-015021-pol2qm74 7844 30 ( ( -LRB- cord-015021-pol2qm74 7844 31 4 4 CD cord-015021-pol2qm74 7844 32 % % NN cord-015021-pol2qm74 7844 33 ) ) -RRB- cord-015021-pol2qm74 7844 34 of of IN cord-015021-pol2qm74 7844 35 27 27 CD cord-015021-pol2qm74 7844 36 patients patient NNS cord-015021-pol2qm74 7844 37 who who WP cord-015021-pol2qm74 7844 38 received receive VBD cord-015021-pol2qm74 7844 39 immunoglobulln immunoglobulln NN cord-015021-pol2qm74 7844 40 . . . cord-015021-pol2qm74 7845 1 By by IN cord-015021-pol2qm74 7845 2 comparison comparison NN cord-015021-pol2qm74 7845 3 , , , cord-015021-pol2qm74 7845 4 nine nine CD cord-015021-pol2qm74 7845 5 ( ( -LRB- cord-015021-pol2qm74 7845 6 32 32 CD cord-015021-pol2qm74 7845 7 % % NN cord-015021-pol2qm74 7845 8 ) ) -RRB- cord-015021-pol2qm74 7845 9 of of IN cord-015021-pol2qm74 7845 10 28 28 CD cord-015021-pol2qm74 7845 11 control control NN cord-015021-pol2qm74 7845 12 group group NN cord-015021-pol2qm74 7845 13 patients patient NNS cord-015021-pol2qm74 7845 14 died die VBD cord-015021-pol2qm74 7845 15 during during IN cord-015021-pol2qm74 7845 16 this this DT cord-015021-pol2qm74 7845 17 period period NN cord-015021-pol2qm74 7845 18 ( ( -LRB- cord-015021-pol2qm74 7845 19 p p NN cord-015021-pol2qm74 7845 20 < < XX cord-015021-pol2qm74 7845 21 . . . cord-015021-pol2qm74 7845 22 01 01 CD cord-015021-pol2qm74 7845 23 ) ) -RRB- cord-015021-pol2qm74 7845 24 . . . cord-015021-pol2qm74 7846 1 Within within IN cord-015021-pol2qm74 7846 2 the the DT cord-015021-pol2qm74 7846 3 first first JJ cord-015021-pol2qm74 7846 4 48 48 CD cord-015021-pol2qm74 7846 5 hrs hrs NN cord-015021-pol2qm74 7846 6 after after IN cord-015021-pol2qm74 7846 7 onset onset NN cord-015021-pol2qm74 7846 8 of of IN cord-015021-pol2qm74 7846 9 the the DT cord-015021-pol2qm74 7846 10 clinically clinically RB cord-015021-pol2qm74 7846 11 apparent apparent JJ cord-015021-pol2qm74 7846 12 septie septie NN cord-015021-pol2qm74 7846 13 process process NN cord-015021-pol2qm74 7846 14 , , , cord-015021-pol2qm74 7846 15 significaptly significaptly RB cord-015021-pol2qm74 7846 16 increased increase VBN cord-015021-pol2qm74 7846 17 activity activity NN cord-015021-pol2qm74 7846 18 of of IN cord-015021-pol2qm74 7846 19 circulating circulate VBG cord-015021-pol2qm74 7846 20 endotoxin endotoxin NN cord-015021-pol2qm74 7846 21 and and CC cord-015021-pol2qm74 7846 22 simultaneously simultaneously RB cord-015021-pol2qm74 7846 23 decreased decrease VBD cord-015021-pol2qm74 7846 24 specifie specifie NN cord-015021-pol2qm74 7846 25 IgG IgG NNP cord-015021-pol2qm74 7846 26 serum serum NN cord-015021-pol2qm74 7846 27 titers titer NNS cord-015021-pol2qm74 7846 28 to to TO cord-015021-pol2qm74 7846 29 lipid lipid VB cord-015021-pol2qm74 7846 30 A a DT cord-015021-pol2qm74 7846 31 were be VBD cord-015021-pol2qm74 7846 32 detected detect VBN cord-015021-pol2qm74 7846 33 in in IN cord-015021-pol2qm74 7846 34 the the DT cord-015021-pol2qm74 7846 35 group group NN cord-015021-pol2qm74 7846 36 of of IN cord-015021-pol2qm74 7846 37 nonsurvivors nonsurvivors NNP cord-015021-pol2qm74 7846 38 . . . cord-015021-pol2qm74 7847 1 The the DT cord-015021-pol2qm74 7847 2 rationale rationale NN cord-015021-pol2qm74 7847 3 for for IN cord-015021-pol2qm74 7847 4 the the DT cord-015021-pol2qm74 7847 5 use use NN cord-015021-pol2qm74 7847 6 of of IN cord-015021-pol2qm74 7847 7 polyvalent polyvalent JJ cord-015021-pol2qm74 7847 8 intravenous intravenous JJ cord-015021-pol2qm74 7847 9 immunogiobulins immunogiobulin NNS cord-015021-pol2qm74 7847 10 ( ( -LRB- cord-015021-pol2qm74 7847 11 IVIG IVIG NNP cord-015021-pol2qm74 7847 12 ) ) -RRB- cord-015021-pol2qm74 7847 13 to to TO cord-015021-pol2qm74 7847 14 treat treat VB cord-015021-pol2qm74 7847 15 severe severe JJ cord-015021-pol2qm74 7847 16 infections infection NNS cord-015021-pol2qm74 7847 17 stems stem VBZ cord-015021-pol2qm74 7847 18 from from IN cord-015021-pol2qm74 7847 19 in in IN cord-015021-pol2qm74 7847 20 vitro vitro FW cord-015021-pol2qm74 7847 21 and and CC cord-015021-pol2qm74 7847 22 animal animal NN cord-015021-pol2qm74 7847 23 studies study NNS cord-015021-pol2qm74 7847 24 documenting document VBG cord-015021-pol2qm74 7847 25 that that IN cord-015021-pol2qm74 7847 26 high high JJ cord-015021-pol2qm74 7847 27 - - HYPH cord-015021-pol2qm74 7847 28 dose dose NN cord-015021-pol2qm74 7847 29 IgG igg NN cord-015021-pol2qm74 7847 30 enhance enhance VB cord-015021-pol2qm74 7847 31 opsonization opsonization NN cord-015021-pol2qm74 7847 32 and and CC cord-015021-pol2qm74 7847 33 phagocytosis phagocytosis NN cord-015021-pol2qm74 7847 34 of of IN cord-015021-pol2qm74 7847 35 pathogenic pathogenic JJ cord-015021-pol2qm74 7847 36 bacteria bacteria NNS cord-015021-pol2qm74 7847 37 . . . cord-015021-pol2qm74 7848 1 Moreover moreover RB cord-015021-pol2qm74 7848 2 , , , cord-015021-pol2qm74 7848 3 recent recent JJ cord-015021-pol2qm74 7848 4 clinical clinical JJ cord-015021-pol2qm74 7848 5 studies study NNS cord-015021-pol2qm74 7848 6 have have VBP cord-015021-pol2qm74 7848 7 shown show VBN cord-015021-pol2qm74 7848 8 that that IN cord-015021-pol2qm74 7848 9 in in IN cord-015021-pol2qm74 7848 10 septic septic JJ cord-015021-pol2qm74 7848 11 patients patient NNS cord-015021-pol2qm74 7848 12 the the DT cord-015021-pol2qm74 7848 13 phagocytic phagocytic JJ cord-015021-pol2qm74 7848 14 function function NN cord-015021-pol2qm74 7848 15 of of IN cord-015021-pol2qm74 7848 16 circulating circulate VBG cord-015021-pol2qm74 7848 17 polymorphonuclear polymorphonuclear JJ cord-015021-pol2qm74 7848 18 neutrophils neutrophil NNS cord-015021-pol2qm74 7848 19 ( ( -LRB- cord-015021-pol2qm74 7848 20 PMN PMN NNP cord-015021-pol2qm74 7848 21 ) ) -RRB- cord-015021-pol2qm74 7848 22 is be VBZ cord-015021-pol2qm74 7848 23 defective defective JJ cord-015021-pol2qm74 7848 24 ; ; : cord-015021-pol2qm74 7848 25 the the DT cord-015021-pol2qm74 7848 26 degree degree NN cord-015021-pol2qm74 7848 27 of of IN cord-015021-pol2qm74 7848 28 such such JJ cord-015021-pol2qm74 7848 29 impairment impairment NN cord-015021-pol2qm74 7848 30 correlates correlate VBZ cord-015021-pol2qm74 7848 31 to to IN cord-015021-pol2qm74 7848 32 the the DT cord-015021-pol2qm74 7848 33 severity severity NN cord-015021-pol2qm74 7848 34 of of IN cord-015021-pol2qm74 7848 35 the the DT cord-015021-pol2qm74 7848 36 septic septic JJ cord-015021-pol2qm74 7848 37 state state NN cord-015021-pol2qm74 7849 1 , , , cord-015021-pol2qm74 7849 2 The the DT cord-015021-pol2qm74 7849 3 beneficial beneficial JJ cord-015021-pol2qm74 7849 4 effect effect NN cord-015021-pol2qm74 7849 5 of of IN cord-015021-pol2qm74 7849 6 administering administer VBG cord-015021-pol2qm74 7849 7 high high JJ cord-015021-pol2qm74 7849 8 dose dose NN cord-015021-pol2qm74 7849 9 IgO igo NN cord-015021-pol2qm74 7849 10 in in IN cord-015021-pol2qm74 7849 11 septic septic JJ cord-015021-pol2qm74 7849 12 patients patient NNS cord-015021-pol2qm74 7849 13 can can MD cord-015021-pol2qm74 7849 14 be be VB cord-015021-pol2qm74 7850 1 two two LS cord-015021-pol2qm74 7850 2 - - HYPH cord-015021-pol2qm74 7850 3 fold fold RB cord-015021-pol2qm74 7850 4 : : : cord-015021-pol2qm74 7850 5 I i NN cord-015021-pol2qm74 7850 6 ) ) -RRB- cord-015021-pol2qm74 7850 7 IVIG IVIG NNP cord-015021-pol2qm74 7850 8 provides provide VBZ cord-015021-pol2qm74 7850 9 large large JJ cord-015021-pol2qm74 7850 10 quantities quantity NNS cord-015021-pol2qm74 7850 11 of of IN cord-015021-pol2qm74 7850 12 antibodies antibody NNS cord-015021-pol2qm74 7850 13 against against IN cord-015021-pol2qm74 7850 14 invading invade VBG cord-015021-pol2qm74 7850 15 pathogens pathogen NNS cord-015021-pol2qm74 7850 16 ; ; : cord-015021-pol2qm74 7850 17 the the DT cord-015021-pol2qm74 7850 18 IgG igg NN cord-015021-pol2qm74 7850 19 bound bind VBN cord-015021-pol2qm74 7850 20 to to IN cord-015021-pol2qm74 7850 21 the the DT cord-015021-pol2qm74 7850 22 pathogens pathogen NNS cord-015021-pol2qm74 7850 23 can can MD cord-015021-pol2qm74 7850 24 opsonize opsonize VB cord-015021-pol2qm74 7850 25 their -PRON- PRP$ cord-015021-pol2qm74 7850 26 phagocytosis phagocytosis NN cord-015021-pol2qm74 7850 27 ; ; : cord-015021-pol2qm74 7850 28 2 2 LS cord-015021-pol2qm74 7850 29 ) ) -RRB- cord-015021-pol2qm74 7850 30 the the DT cord-015021-pol2qm74 7850 31 opsonization opsonization NN cord-015021-pol2qm74 7850 32 of of IN cord-015021-pol2qm74 7850 33 phagocytosis phagocytosis NN cord-015021-pol2qm74 7850 34 by by IN cord-015021-pol2qm74 7850 35 exogenously exogenously RB cord-015021-pol2qm74 7850 36 administred administre VBN cord-015021-pol2qm74 7850 37 polyvalent polyvalent JJ cord-015021-pol2qm74 7850 38 IgO igo NN cord-015021-pol2qm74 7850 39 would would MD cord-015021-pol2qm74 7850 40 be be VB cord-015021-pol2qm74 7850 41 of of IN cord-015021-pol2qm74 7850 42 special special JJ cord-015021-pol2qm74 7850 43 importance importance NN cord-015021-pol2qm74 7850 44 in in IN cord-015021-pol2qm74 7850 45 those those DT cord-015021-pol2qm74 7850 46 patients patient NNS cord-015021-pol2qm74 7850 47 who who WP cord-015021-pol2qm74 7850 48 present present VBP cord-015021-pol2qm74 7850 49 a a DT cord-015021-pol2qm74 7850 50 significant significant JJ cord-015021-pol2qm74 7850 51 defect defect NN cord-015021-pol2qm74 7850 52 of of IN cord-015021-pol2qm74 7850 53 their -PRON- PRP$ cord-015021-pol2qm74 7850 54 phagocytic phagocytic JJ cord-015021-pol2qm74 7850 55 function function NN cord-015021-pol2qm74 7850 56 , , , cord-015021-pol2qm74 7850 57 when when WRB cord-015021-pol2qm74 7850 58 they -PRON- PRP cord-015021-pol2qm74 7850 59 are be VBP cord-015021-pol2qm74 7850 60 challanged challange VBN cord-015021-pol2qm74 7850 61 by by IN cord-015021-pol2qm74 7850 62 a a DT cord-015021-pol2qm74 7850 63 large large JJ cord-015021-pol2qm74 7850 64 bacterial bacterial JJ cord-015021-pol2qm74 7850 65 invasion invasion NN cord-015021-pol2qm74 7850 66 . . . cord-015021-pol2qm74 7851 1 A a DT cord-015021-pol2qm74 7851 2 prospective prospective NN cord-015021-pol2qm74 7851 3 , , , cord-015021-pol2qm74 7851 4 randomized randomized JJ cord-015021-pol2qm74 7851 5 , , , cord-015021-pol2qm74 7851 6 double double JJ cord-015021-pol2qm74 7851 7 - - HYPH cord-015021-pol2qm74 7851 8 blind blind JJ cord-015021-pol2qm74 7851 9 study study NN cord-015021-pol2qm74 7851 10 was be VBD cord-015021-pol2qm74 7851 11 carried carry VBN cord-015021-pol2qm74 7851 12 out out RP cord-015021-pol2qm74 7851 13 comparing compare VBG cord-015021-pol2qm74 7851 14 the the DT cord-015021-pol2qm74 7851 15 administration administration NN cord-015021-pol2qm74 7851 16 of of IN cord-015021-pol2qm74 7851 17 IVIG IVIG NNP cord-015021-pol2qm74 7851 18 ( ( -LRB- cord-015021-pol2qm74 7851 19 Sandoglobulin@ sandoglobulin@ NN cord-015021-pol2qm74 7851 20 ) ) -RRB- cord-015021-pol2qm74 7851 21 vs vs NNP cord-015021-pol2qm74 7851 22 , , , cord-015021-pol2qm74 7851 23 paeebo paeebo NNP cord-015021-pol2qm74 7851 24 ( ( -LRB- cord-015021-pol2qm74 7851 25 human human JJ cord-015021-pol2qm74 7851 26 albumin albumin NN cord-015021-pol2qm74 7851 27 ) ) -RRB- cord-015021-pol2qm74 7851 28 in in IN cord-015021-pol2qm74 7851 29 severely severely RB cord-015021-pol2qm74 7851 30 septic septic JJ cord-015021-pol2qm74 7851 31 surgical surgical JJ cord-015021-pol2qm74 7851 32 patients patient NNS cord-015021-pol2qm74 7851 33 , , , cord-015021-pol2qm74 7851 34 Only only RB cord-015021-pol2qm74 7851 35 patients patient NNS cord-015021-pol2qm74 7851 36 with with IN cord-015021-pol2qm74 7851 37 gepis gepis NN cord-015021-pol2qm74 7851 38 score score NN cord-015021-pol2qm74 7852 1 > > XX cord-015021-pol2qm74 7853 1 _ _ NN cord-015021-pol2qm74 7853 2 20 20 CD cord-015021-pol2qm74 7853 3 ( ( -LRB- cord-015021-pol2qm74 7853 4 meaning mean VBG cord-015021-pol2qm74 7853 5 a a DT cord-015021-pol2qm74 7853 6 mortality mortality NN cord-015021-pol2qm74 7853 7 risk risk NN cord-015021-pol2qm74 7853 8 > > XX cord-015021-pol2qm74 7853 9 70 70 CD cord-015021-pol2qm74 7853 10 % % NN cord-015021-pol2qm74 7853 11 ) ) -RRB- cord-015021-pol2qm74 7853 12 were be VBD cord-015021-pol2qm74 7853 13 accepted accept VBN cord-015021-pol2qm74 7853 14 into into IN cord-015021-pol2qm74 7853 15 this this DT cord-015021-pol2qm74 7853 16 protocol protocol NN cord-015021-pol2qm74 7853 17 . . . cord-015021-pol2qm74 7854 1 Patients patient NNS cord-015021-pol2qm74 7854 2 were be VBD cord-015021-pol2qm74 7854 3 randomized randomize VBN cord-015021-pol2qm74 7854 4 to to TO cord-015021-pol2qm74 7854 5 receive receive VB cord-015021-pol2qm74 7854 6 0.4 0.4 CD cord-015021-pol2qm74 7854 7 g g NN cord-015021-pol2qm74 7854 8 / / SYM cord-015021-pol2qm74 7854 9 Kg Kg NNP cord-015021-pol2qm74 7854 10 of of IN cord-015021-pol2qm74 7854 11 IVIG IVIG NNP cord-015021-pol2qm74 7854 12 or or CC cord-015021-pol2qm74 7854 13 placebo placebo NN cord-015021-pol2qm74 7854 14 on on IN cord-015021-pol2qm74 7854 15 day day NN cord-015021-pol2qm74 7854 16 0 0 NFP cord-015021-pol2qm74 7854 17 ( ( -LRB- cord-015021-pol2qm74 7854 18 when when WRB cord-015021-pol2qm74 7854 19 they -PRON- PRP cord-015021-pol2qm74 7854 20 reached reach VBD cord-015021-pol2qm74 7854 21 sepsis sepsis NN cord-015021-pol2qm74 7854 22 score>20 score>20 NNS cord-015021-pol2qm74 7854 23 ) ) -RRB- cord-015021-pol2qm74 7854 24 , , , cord-015021-pol2qm74 7854 25 repeated repeat VBN cord-015021-pol2qm74 7854 26 on on IN cord-015021-pol2qm74 7854 27 day day NN cord-015021-pol2qm74 7854 28 +1 +1 NFP cord-015021-pol2qm74 7854 29 and and CC cord-015021-pol2qm74 7854 30 +5 +5 NN cord-015021-pol2qm74 7854 31 . . . cord-015021-pol2qm74 7855 1 At at IN cord-015021-pol2qm74 7855 2 the the DT cord-015021-pol2qm74 7855 3 beginning beginning NN cord-015021-pol2qm74 7855 4 of of IN cord-015021-pol2qm74 7855 5 ICU ICU NNP cord-015021-pol2qm74 7855 6 treatment treatment NN cord-015021-pol2qm74 7855 7 , , , cord-015021-pol2qm74 7855 8 the the DT cord-015021-pol2qm74 7855 9 two two CD cord-015021-pol2qm74 7855 10 groups group NNS cord-015021-pol2qm74 7855 11 of of IN cord-015021-pol2qm74 7855 12 patients patient NNS cord-015021-pol2qm74 7855 13 were be VBD cord-015021-pol2qm74 7855 14 similar similar JJ cord-015021-pol2qm74 7855 15 for for IN cord-015021-pol2qm74 7855 16 severity severity NN cord-015021-pol2qm74 7855 17 of of IN cord-015021-pol2qm74 7855 18 sepsis sepsis NN cord-015021-pol2qm74 7855 19 , , , cord-015021-pol2qm74 7855 20 age age NN cord-015021-pol2qm74 7855 21 , , , cord-015021-pol2qm74 7855 22 concomitant concomitant JJ cord-015021-pol2qm74 7855 23 disease disease NN cord-015021-pol2qm74 7855 24 , , , cord-015021-pol2qm74 7855 25 type type NN cord-015021-pol2qm74 7855 26 of of IN cord-015021-pol2qm74 7855 27 surgical surgical JJ cord-015021-pol2qm74 7855 28 procedures procedure NNS cord-015021-pol2qm74 7855 29 , , , cord-015021-pol2qm74 7855 30 antra antra NNP cord-015021-pol2qm74 7855 31 and and CC cord-015021-pol2qm74 7855 32 perioperative perioperative JJ cord-015021-pol2qm74 7855 33 procedures procedure NNS cord-015021-pol2qm74 7855 34 , , , cord-015021-pol2qm74 7855 35 antibiotic antibiotic JJ cord-015021-pol2qm74 7855 36 administration administration NN cord-015021-pol2qm74 7855 37 . . . cord-015021-pol2qm74 7856 1 The the DT cord-015021-pol2qm74 7856 2 results result NNS cord-015021-pol2qm74 7856 3 of of IN cord-015021-pol2qm74 7856 4 the the DT cord-015021-pol2qm74 7856 5 study study NN cord-015021-pol2qm74 7856 6 indicated indicate VBD cord-015021-pol2qm74 7856 7 a a DT cord-015021-pol2qm74 7856 8 significantly significantly RB cord-015021-pol2qm74 7856 9 reduced reduce VBN cord-015021-pol2qm74 7856 10 mortality mortality NN cord-015021-pol2qm74 7856 11 in in IN cord-015021-pol2qm74 7856 12 patients patient NNS cord-015021-pol2qm74 7856 13 with with IN cord-015021-pol2qm74 7856 14 severe severe JJ cord-015021-pol2qm74 7856 15 surgical surgical JJ cord-015021-pol2qm74 7856 16 sepsis sepsis NN cord-015021-pol2qm74 7856 17 treated treat VBN cord-015021-pol2qm74 7856 18 with with IN cord-015021-pol2qm74 7856 19 IVIG IVIG NNP cord-015021-pol2qm74 7856 20 as as IN cord-015021-pol2qm74 7856 21 compared compare VBN cord-015021-pol2qm74 7856 22 to to IN cord-015021-pol2qm74 7856 23 placebo placebo NN cord-015021-pol2qm74 7856 24 control control NN cord-015021-pol2qm74 7856 25 patients patient NNS cord-015021-pol2qm74 7856 26 ( ( -LRB- cord-015021-pol2qm74 7856 27 mortality mortality NN cord-015021-pol2qm74 7856 28 : : : cord-015021-pol2qm74 7856 29 38 38 CD cord-015021-pol2qm74 7856 30 % % NN cord-015021-pol2qm74 7856 31 vs vs IN cord-015021-pol2qm74 7856 32 , , , cord-015021-pol2qm74 7856 33 67 67 CD cord-015021-pol2qm74 7856 34 % % NN cord-015021-pol2qm74 7856 35 respectively respectively RB cord-015021-pol2qm74 7856 36 ; ; . cord-015021-pol2qm74 7857 1 p p NN cord-015021-pol2qm74 7857 2 < < XX cord-015021-pol2qm74 7857 3 0,05 0,05 NNP cord-015021-pol2qm74 7857 4 ) ) -RRB- cord-015021-pol2qm74 7857 5 . . . cord-015021-pol2qm74 7858 1 In in IN cord-015021-pol2qm74 7858 2 conclusion conclusion NN cord-015021-pol2qm74 7858 3 , , , cord-015021-pol2qm74 7858 4 the the DT cord-015021-pol2qm74 7858 5 results result NNS cord-015021-pol2qm74 7858 6 of of IN cord-015021-pol2qm74 7858 7 our -PRON- PRP$ cord-015021-pol2qm74 7858 8 study study NN cord-015021-pol2qm74 7858 9 in in IN cord-015021-pol2qm74 7858 10 patients patient NNS cord-015021-pol2qm74 7858 11 with with IN cord-015021-pol2qm74 7858 12 severe severe JJ cord-015021-pol2qm74 7858 13 surgical surgical JJ cord-015021-pol2qm74 7858 14 sepsis sepsis NN cord-015021-pol2qm74 7858 15 were be VBD cord-015021-pol2qm74 7858 16 the the DT cord-015021-pol2qm74 7858 17 following follow VBG cord-015021-pol2qm74 7858 18 : : : cord-015021-pol2qm74 7859 1 1 1 LS cord-015021-pol2qm74 7859 2 ) ) -RRB- cord-015021-pol2qm74 7859 3 IVIG IVIG NNP cord-015021-pol2qm74 7859 4 plus plus CC cord-015021-pol2qm74 7859 5 multimodal multimodal NN cord-015021-pol2qm74 7859 6 treatment treatment NN cord-015021-pol2qm74 7859 7 of of IN cord-015021-pol2qm74 7859 8 sepsis sepsis NN cord-015021-pol2qm74 7859 9 , , , cord-015021-pol2qm74 7859 10 including include VBG cord-015021-pol2qm74 7859 11 antibiotics antibiotic NNS cord-015021-pol2qm74 7859 12 , , , cord-015021-pol2qm74 7859 13 reduce reduce VB cord-015021-pol2qm74 7859 14 mortality mortality NN cord-015021-pol2qm74 7859 15 significantly significantly RB cord-015021-pol2qm74 7859 16 ' ' '' cord-015021-pol2qm74 7859 17 , , , cord-015021-pol2qm74 7859 18 2 2 CD cord-015021-pol2qm74 7859 19 ) ) -RRB- cord-015021-pol2qm74 7859 20 the the DT cord-015021-pol2qm74 7859 21 reduction reduction NN cord-015021-pol2qm74 7859 22 of of IN cord-015021-pol2qm74 7859 23 mortality mortality NN cord-015021-pol2qm74 7859 24 seems seem VBZ cord-015021-pol2qm74 7859 25 to to TO cord-015021-pol2qm74 7859 26 be be VB cord-015021-pol2qm74 7859 27 due due JJ cord-015021-pol2qm74 7859 28 to to IN cord-015021-pol2qm74 7859 29 a a DT cord-015021-pol2qm74 7859 30 decreased decrease VBN cord-015021-pol2qm74 7859 31 incidence incidence NN cord-015021-pol2qm74 7859 32 of of IN cord-015021-pol2qm74 7859 33 lethal lethal JJ cord-015021-pol2qm74 7859 34 septic septic JJ cord-015021-pol2qm74 7859 35 shock shock NN cord-015021-pol2qm74 7859 36 . . . cord-015021-pol2qm74 7860 1 Despite despite IN cord-015021-pol2qm74 7860 2 substantial substantial JJ cord-015021-pol2qm74 7860 3 clinical clinical JJ cord-015021-pol2qm74 7860 4 research research NN cord-015021-pol2qm74 7860 5 , , , cord-015021-pol2qm74 7860 6 the the DT cord-015021-pol2qm74 7860 7 avallable avallable JJ cord-015021-pol2qm74 7860 8 data datum NNS cord-015021-pol2qm74 7860 9 regarding regard VBG cord-015021-pol2qm74 7860 10 the the DT cord-015021-pol2qm74 7860 11 effectiveness effectiveness NN cord-015021-pol2qm74 7860 12 of of IN cord-015021-pol2qm74 7860 13 supplemental supplemental JJ cord-015021-pol2qm74 7860 14 immunoglobulin immunoglobulin NN cord-015021-pol2qm74 7860 15 ( ( -LRB- cord-015021-pol2qm74 7860 16 Ig Ig NNP cord-015021-pol2qm74 7860 17 ) ) -RRB- cord-015021-pol2qm74 7860 18 treatment treatment NN cord-015021-pol2qm74 7860 19 in in IN cord-015021-pol2qm74 7860 20 sepsis sepsis NN cord-015021-pol2qm74 7860 21 in in IN cord-015021-pol2qm74 7860 22 adult adult NN cord-015021-pol2qm74 7860 23 patients patient NNS cord-015021-pol2qm74 7860 24 do do VBP cord-015021-pol2qm74 7860 25 not not RB cord-015021-pol2qm74 7860 26 yet yet RB cord-015021-pol2qm74 7860 27 allow allow VB cord-015021-pol2qm74 7860 28 definitive definitive JJ cord-015021-pol2qm74 7860 29 conclusions conclusion NNS cord-015021-pol2qm74 7860 30 . . . cord-015021-pol2qm74 7861 1 In in IN cord-015021-pol2qm74 7861 2 view view NN cord-015021-pol2qm74 7861 3 of of IN cord-015021-pol2qm74 7861 4 the the DT cord-015021-pol2qm74 7861 5 persistently persistently RB cord-015021-pol2qm74 7861 6 high high JJ cord-015021-pol2qm74 7861 7 sepsis sepsis NN cord-015021-pol2qm74 7861 8 mortality mortality NN cord-015021-pol2qm74 7861 9 there there EX cord-015021-pol2qm74 7861 10 is be VBZ cord-015021-pol2qm74 7861 11 a a DT cord-015021-pol2qm74 7861 12 need need NN cord-015021-pol2qm74 7861 13 to to TO cord-015021-pol2qm74 7861 14 continue continue VB cord-015021-pol2qm74 7861 15 clinical clinical JJ cord-015021-pol2qm74 7861 16 investxqations investxqation NNS cord-015021-pol2qm74 7861 17 regarding regard VBG cord-015021-pol2qm74 7861 18 supplemental supplemental JJ cord-015021-pol2qm74 7861 19 sepsis sepsis NN cord-015021-pol2qm74 7861 20 treatmen~ treatmen~ NN cord-015021-pol2qm74 7861 21 in in IN cord-015021-pol2qm74 7861 22 general general JJ cord-015021-pol2qm74 7861 23 , , , cord-015021-pol2qm74 7861 24 as as RB cord-015021-pol2qm74 7861 25 well well RB cord-015021-pol2qm74 7861 26 as as IN cord-015021-pol2qm74 7861 27 concerning concern VBG cord-015021-pol2qm74 7861 28 Ig Ig NNP cord-015021-pol2qm74 7861 29 administration administration NN cord-015021-pol2qm74 7861 30 in in IN cord-015021-pol2qm74 7861 31 particular particular JJ cord-015021-pol2qm74 7861 32 . . . cord-015021-pol2qm74 7862 1 We -PRON- PRP cord-015021-pol2qm74 7862 2 present present VBP cord-015021-pol2qm74 7862 3 and and CC cord-015021-pol2qm74 7862 4 discuss discuss VB cord-015021-pol2qm74 7862 5 the the DT cord-015021-pol2qm74 7862 6 protocol protocol NN cord-015021-pol2qm74 7862 7 of of IN cord-015021-pol2qm74 7862 8 the the DT cord-015021-pol2qm74 7862 9 ongoing ongoing JJ cord-015021-pol2qm74 7862 10 , , , cord-015021-pol2qm74 7862 11 , , , cord-015021-pol2qm74 7862 12 Score score NN cord-015021-pol2qm74 7862 13 - - HYPH cord-015021-pol2qm74 7862 14 Based Based NNP cord-015021-pol2qm74 7862 15 - - HYPH cord-015021-pol2qm74 7862 16 Immuneglobulin Immuneglobulin NNP cord-015021-pol2qm74 7862 17 Therapy Therapy NNP cord-015021-pol2qm74 7862 18 of of IN cord-015021-pol2qm74 7862 19 Sepsis Sepsis NNP cord-015021-pol2qm74 7862 20 ( ( -LRB- cord-015021-pol2qm74 7862 21 SBITS SBITS NNP cord-015021-pol2qm74 7862 22 ) ) -RRB- cord-015021-pol2qm74 7862 23 " " `` cord-015021-pol2qm74 7862 24 study study NN cord-015021-pol2qm74 7862 25 . . . cord-015021-pol2qm74 7863 1 The the DT cord-015021-pol2qm74 7863 2 protocol protocol NN cord-015021-pol2qm74 7863 3 ( ( -LRB- cord-015021-pol2qm74 7863 4 Theoret Theoret NNP cord-015021-pol2qm74 7863 5 Surg Surg NNP cord-015021-pol2qm74 7863 6 8(1993)61 8(1993)61 NN cord-015021-pol2qm74 7863 7 - - HYPH cord-015021-pol2qm74 7863 8 83 83 CD cord-015021-pol2qm74 7863 9 ) ) -RRB- cord-015021-pol2qm74 7863 10 of of IN cord-015021-pol2qm74 7863 11 this this DT cord-015021-pol2qm74 7863 12 multicenter multicenter NN cord-015021-pol2qm74 7863 13 , , , cord-015021-pol2qm74 7863 14 randomized randomized JJ cord-015021-pol2qm74 7863 15 , , , cord-015021-pol2qm74 7863 16 prospective prospective JJ cord-015021-pol2qm74 7863 17 and and CC cord-015021-pol2qm74 7863 18 double double JJ cord-015021-pol2qm74 7863 19 - - HYPH cord-015021-pol2qm74 7863 20 blind blind JJ cord-015021-pol2qm74 7863 21 trfal trfal NN cord-015021-pol2qm74 7863 22 relies rely VBZ cord-015021-pol2qm74 7863 23 on on IN cord-015021-pol2qm74 7863 24 the the DT cord-015021-pol2qm74 7863 25 results result NNS cord-015021-pol2qm74 7863 26 of of IN cord-015021-pol2qm74 7863 27 an an DT cord-015021-pol2qm74 7863 28 observational observational JJ cord-015021-pol2qm74 7863 29 trial trial NN cord-015021-pol2qm74 7863 30 on on IN cord-015021-pol2qm74 7863 31 i.v i.v NNP cord-015021-pol2qm74 7863 32 . . NNP cord-015021-pol2qm74 7863 33 IgG IgG NNP cord-015021-pol2qm74 7863 34 treatment treatment NN cord-015021-pol2qm74 7863 35 in in IN cord-015021-pol2qm74 7863 36 163 163 CD cord-015021-pol2qm74 7863 37 patients patient NNS cord-015021-pol2qm74 7863 38 with with IN cord-015021-pol2qm74 7863 39 sepsis sepsis NN cord-015021-pol2qm74 7863 40 and and CC cord-015021-pol2qm74 7863 41 septic septic JJ cord-015021-pol2qm74 7863 42 shock shock NN cord-015021-pol2qm74 7863 43 ( ( -LRB- cord-015021-pol2qm74 7863 44 Infection infection NN cord-015021-pol2qm74 7863 45 19~1991)216 19~1991)216 NN cord-015021-pol2qm74 7863 46 - - HYPH cord-015021-pol2qm74 7863 47 227 227 CD cord-015021-pol2qm74 7863 48 ) ) -RRB- cord-015021-pol2qm74 7863 49 , , , cord-015021-pol2qm74 7863 50 carried carry VBD cord-015021-pol2qm74 7863 51 out out RP cord-015021-pol2qm74 7863 52 as as IN cord-015021-pol2qm74 7863 53 a a DT cord-015021-pol2qm74 7863 54 prerequisite prerequisite NN cord-015021-pol2qm74 7863 55 for for IN cord-015021-pol2qm74 7863 56 the the DT cord-015021-pol2qm74 7863 57 present present JJ cord-015021-pol2qm74 7863 58 trial trial NN cord-015021-pol2qm74 7863 59 . . . cord-015021-pol2qm74 7864 1 Using use VBG cord-015021-pol2qm74 7864 2 microcomputer microcomputer NN cord-015021-pol2qm74 7864 3 - - HYPH cord-015021-pol2qm74 7864 4 based base VBN cord-015021-pol2qm74 7864 5 bedside bedside NN cord-015021-pol2qm74 7864 6 routine routine JJ cord-015021-pol2qm74 7864 7 score score NN cord-015021-pol2qm74 7864 8 monitoring monitoring NN cord-015021-pol2qm74 7864 9 , , , cord-015021-pol2qm74 7864 10 we -PRON- PRP cord-015021-pol2qm74 7864 11 regard regard VBP cord-015021-pol2qm74 7864 12 quantitative quantitative JJ cord-015021-pol2qm74 7864 13 measures measure NNS cord-015021-pol2qm74 7864 14 of of IN cord-015021-pol2qm74 7864 15 severity severity NN cord-015021-pol2qm74 7864 16 of of IN cord-015021-pol2qm74 7864 17 disease disease NN cord-015021-pol2qm74 7864 18 and and CC cord-015021-pol2qm74 7864 19 sepsis sepsis NN cord-015021-pol2qm74 7864 20 : : : cord-015021-pol2qm74 7864 21 only only RB cord-015021-pol2qm74 7864 22 patients patient NNS cord-015021-pol2qm74 7864 23 with with IN cord-015021-pol2qm74 7864 24 a a DT cord-015021-pol2qm74 7864 25 certain certain JJ cord-015021-pol2qm74 7864 26 degree degree NN cord-015021-pol2qm74 7864 27 of of IN cord-015021-pol2qm74 7864 28 both both DT cord-015021-pol2qm74 7864 29 severity severity NN cord-015021-pol2qm74 7864 30 of of IN cord-015021-pol2qm74 7864 31 disease disease NN cord-015021-pol2qm74 7864 32 ( ( -LRB- cord-015021-pol2qm74 7864 33 APACHE APACHE NNP cord-015021-pol2qm74 7864 34 II II NNP cord-015021-pol2qm74 7864 35 score score NN cord-015021-pol2qm74 7864 36 20 20 CD cord-015021-pol2qm74 7864 37 - - SYM cord-015021-pol2qm74 7864 38 35 35 CD cord-015021-pol2qm74 7864 39 ) ) -RRB- cord-015021-pol2qm74 7864 40 and and CC cord-015021-pol2qm74 7864 41 severity severity NN cord-015021-pol2qm74 7864 42 of of IN cord-015021-pol2qm74 7864 43 sepsis sepsis NN cord-015021-pol2qm74 7864 44 ( ( -LRB- cord-015021-pol2qm74 7864 45 Elebute Elebute NNP cord-015021-pol2qm74 7864 46 sepsis sepsis NN cord-015021-pol2qm74 7864 47 score score NN cord-015021-pol2qm74 7864 48 12 12 CD cord-015021-pol2qm74 7864 49 - - SYM cord-015021-pol2qm74 7864 50 27 27 CD cord-015021-pol2qm74 7864 51 ) ) -RRB- cord-015021-pol2qm74 7864 52 will will MD cord-015021-pol2qm74 7864 53 be be VB cord-015021-pol2qm74 7864 54 included include VBN cord-015021-pol2qm74 7864 55 . . . cord-015021-pol2qm74 7865 1 By by IN cord-015021-pol2qm74 7865 2 observing observe VBG cord-015021-pol2qm74 7865 3 these these DT cord-015021-pol2qm74 7865 4 previously previously RB cord-015021-pol2qm74 7865 5 validated validate VBN cord-015021-pol2qm74 7865 6 inclusion inclusion NN cord-015021-pol2qm74 7865 7 criteria criterion NNS cord-015021-pol2qm74 7865 8 , , , cord-015021-pol2qm74 7865 9 this this DT cord-015021-pol2qm74 7865 10 trial trial NN cord-015021-pol2qm74 7865 11 snould snould MD cord-015021-pol2qm74 7865 12 iQentify iQentify NNP cord-015021-pol2qm74 7865 13 a a FW cord-015021-pol2qm74 7865 14 priori priori FW cord-015021-pol2qm74 7865 15 and and CC cord-015021-pol2qm74 7865 16 include include VBP cord-015021-pol2qm74 7865 17 patients patient NNS cord-015021-pol2qm74 7865 18 with with IN cord-015021-pol2qm74 7865 19 potentially potentially RB cord-015021-pol2qm74 7865 20 optimal optimal JJ cord-015021-pol2qm74 7865 21 response response NN cord-015021-pol2qm74 7865 22 to to IN cord-015021-pol2qm74 7865 23 therapy therapy NN cord-015021-pol2qm74 7865 24 , , , cord-015021-pol2qm74 7865 25 consisting consist VBG cord-015021-pol2qm74 7865 26 o~ o~ XX cord-015021-pol2qm74 7865 27 either either CC cord-015021-pol2qm74 7865 28 placebo placebo NN cord-015021-pol2qm74 7865 29 ( ( -LRB- cord-015021-pol2qm74 7865 30 0.i 0.i CD cord-015021-pol2qm74 7865 31 % % NN cord-015021-pol2qm74 7865 32 albumin albumin NN cord-015021-pol2qm74 7865 33 ) ) -RRB- cord-015021-pol2qm74 7865 34 or or CC cord-015021-pol2qm74 7865 35 Polyglobin Polyglobin NNP cord-015021-pol2qm74 7865 36 N N NNP cord-015021-pol2qm74 7865 37 " " '' cord-015021-pol2qm74 7865 38 -12 -12 : cord-015021-pol2qm74 7865 39 ml ml NN cord-015021-pol2qm74 7865 40 ( ( -LRB- cord-015021-pol2qm74 7865 41 0.6g)/kg 0.6g)/kg CD cord-015021-pol2qm74 7865 42 on on IN cord-015021-pol2qm74 7865 43 day day NN cord-015021-pol2qm74 7865 44 0 0 CD cord-015021-pol2qm74 7865 45 and and CC cord-015021-pol2qm74 7865 46 6ml 6ml NN cord-015021-pol2qm74 7865 47 ( ( -LRB- cord-015021-pol2qm74 7865 48 0.3 0.3 CD cord-015021-pol2qm74 7865 49 g)/kg g)/kg NNS cord-015021-pol2qm74 7865 50 on on IN cord-015021-pol2qm74 7865 51 day day NN cord-015021-pol2qm74 7865 52 i. i. NN cord-015021-pol2qm74 7866 1 With with IN cord-015021-pol2qm74 7866 2 an an DT cord-015021-pol2qm74 7866 3 anticipatedpopulation anticipatedpopulation NN cord-015021-pol2qm74 7866 4 size size NN cord-015021-pol2qm74 7866 5 of of IN cord-015021-pol2qm74 7866 6 800 800 CD cord-015021-pol2qm74 7866 7 patients patient NNS cord-015021-pol2qm74 7866 8 the the DT cord-015021-pol2qm74 7866 9 study study NN cord-015021-pol2qm74 7866 10 should should MD cord-015021-pol2qm74 7866 11 comply comply VB cord-015021-pol2qm74 7866 12 with with IN cord-015021-pol2qm74 7866 13 the the DT cord-015021-pol2qm74 7866 14 statlstical statlstical JJ cord-015021-pol2qm74 7866 15 requirements requirement NNS cord-015021-pol2qm74 7866 16 ( ( -LRB- cord-015021-pol2qm74 7866 17 estimated estimate VBN cord-015021-pol2qm74 7866 18 mortality mortality NN cord-015021-pol2qm74 7866 19 : : : cord-015021-pol2qm74 7866 20 30 30 CD cord-015021-pol2qm74 7866 21 % % NN cord-015021-pol2qm74 7866 22 , , , cord-015021-pol2qm74 7866 23 with with IN cord-015021-pol2qm74 7866 24 a a DT cord-015021-pol2qm74 7866 25 33 33 CD cord-015021-pol2qm74 7866 26 % % NN cord-015021-pol2qm74 7866 27 reduction reduction NN cord-015021-pol2qm74 7866 28 in in IN cord-015021-pol2qm74 7866 29 28-day 28-day CD cord-015021-pol2qm74 7866 30 mortality mortality NN cord-015021-pol2qm74 7866 31 in in IN cord-015021-pol2qm74 7866 32 the the DT cord-015021-pol2qm74 7866 33 treatment treatment NN cord-015021-pol2qm74 7866 34 groupl groupl NNS cord-015021-pol2qm74 7866 35 to to TO cord-015021-pol2qm74 7866 36 prove prove VB cord-015021-pol2qm74 7866 37 or or CC cord-015021-pol2qm74 7866 38 disprove disprove VB cord-015021-pol2qm74 7866 39 the the DT cord-015021-pol2qm74 7866 40 question question NN cord-015021-pol2qm74 7866 41 of of IN cord-015021-pol2qm74 7866 42 IgG IgG NNP cord-015021-pol2qm74 7866 43 effectiveness effectiveness NN cord-015021-pol2qm74 7866 44 in in IN cord-015021-pol2qm74 7866 45 sepsis sepsis NN cord-015021-pol2qm74 7866 46 in in IN cord-015021-pol2qm74 7866 47 terms term NNS cord-015021-pol2qm74 7866 48 of of IN cord-015021-pol2qm74 7866 49 improved improved JJ cord-015021-pol2qm74 7866 50 prognosis prognosis NN cord-015021-pol2qm74 7866 51 . . . cord-015021-pol2qm74 7867 1 Up up IN cord-015021-pol2qm74 7867 2 to to IN cord-015021-pol2qm74 7867 3 November November NNP cord-015021-pol2qm74 7867 4 1993 1993 CD cord-015021-pol2qm74 7867 5 , , , cord-015021-pol2qm74 7867 6 more more JJR cord-015021-pol2qm74 7867 7 than than IN cord-015021-pol2qm74 7867 8 460 460 CD cord-015021-pol2qm74 7867 9 patients patient NNS cord-015021-pol2qm74 7867 10 had have VBD cord-015021-pol2qm74 7867 11 been be VBN cord-015021-pol2qm74 7867 12 included include VBN cord-015021-pol2qm74 7867 13 ; ; : cord-015021-pol2qm74 7867 14 patient patient JJ cord-015021-pol2qm74 7867 15 enrollment enrollment NN cord-015021-pol2qm74 7867 16 will will MD cord-015021-pol2qm74 7867 17 be be VB cord-015021-pol2qm74 7867 18 finished finish VBN cord-015021-pol2qm74 7867 19 in in IN cord-015021-pol2qm74 7867 20 1994 1994 CD cord-015021-pol2qm74 7867 21 . . . cord-015021-pol2qm74 7868 1 Previous previous JJ cord-015021-pol2qm74 7868 2 studies study NNS cord-015021-pol2qm74 7868 3 have have VBP cord-015021-pol2qm74 7868 4 demonstrated demonstrate VBN cord-015021-pol2qm74 7868 5 rhlL rhll JJ cord-015021-pol2qm74 7868 6 - - : cord-015021-pol2qm74 7868 7 I I NNP cord-015021-pol2qm74 7868 8 ra ra NNP cord-015021-pol2qm74 7868 9 , , , cord-015021-pol2qm74 7868 10 a a DT cord-015021-pol2qm74 7868 11 naturally naturally RB cord-015021-pol2qm74 7868 12 occurring occur VBG cord-015021-pol2qm74 7868 13 antagonist antagonist NN cord-015021-pol2qm74 7868 14 of of IN cord-015021-pol2qm74 7868 15 IL-1 IL-1 NNP cord-015021-pol2qm74 7868 16 , , , cord-015021-pol2qm74 7868 17 increases increase VBZ cord-015021-pol2qm74 7868 18 survival survival NN cord-015021-pol2qm74 7868 19 in in IN cord-015021-pol2qm74 7868 20 animal animal NN cord-015021-pol2qm74 7868 21 models model NNS cord-015021-pol2qm74 7868 22 of of IN cord-015021-pol2qm74 7868 23 andotoxemia andotoxemia NN cord-015021-pol2qm74 7868 24 and and CC cord-015021-pol2qm74 7868 25 EscheHchia EscheHchia NNP cord-015021-pol2qm74 7868 26 coli coli VBZ cord-015021-pol2qm74 7868 27 bacteremia bacteremia NN cord-015021-pol2qm74 7868 28 and and CC cord-015021-pol2qm74 7868 29 attenuates attenuate VBZ cord-015021-pol2qm74 7868 30 the the DT cord-015021-pol2qm74 7868 31 decrease decrease NN cord-015021-pol2qm74 7868 32 in in IN cord-015021-pol2qm74 7868 33 mean mean JJ cord-015021-pol2qm74 7868 34 arterial arterial JJ cord-015021-pol2qm74 7868 35 pressure pressure NN cord-015021-pol2qm74 7868 36 resulting result VBG cord-015021-pol2qm74 7868 37 from from IN cord-015021-pol2qm74 7868 38 challenge challenge NN cord-015021-pol2qm74 7868 39 with with IN cord-015021-pol2qm74 7868 40 both both CC cord-015021-pol2qm74 7868 41 gram gram NN cord-015021-pol2qm74 7868 42 - - HYPH cord-015021-pol2qm74 7868 43 negative negative JJ cord-015021-pol2qm74 7868 44 and and CC cord-015021-pol2qm74 7868 45 gram gram NN cord-015021-pol2qm74 7868 46 - - HYPH cord-015021-pol2qm74 7868 47 positive positive JJ cord-015021-pol2qm74 7868 48 bacteria bacteria NNS cord-015021-pol2qm74 7868 49 . . . cord-015021-pol2qm74 7869 1 Previously previously RB cord-015021-pol2qm74 7869 2 , , , cord-015021-pol2qm74 7869 3 in in IN cord-015021-pol2qm74 7869 4 99 99 CD cord-015021-pol2qm74 7869 5 patients patient NNS cord-015021-pol2qm74 7869 6 , , , cord-015021-pol2qm74 7869 7 rhlL rhlL '' cord-015021-pol2qm74 7869 8 - - HYPH cord-015021-pol2qm74 7869 9 lra lra NNP cord-015021-pol2qm74 7869 10 was be VBD cord-015021-pol2qm74 7869 11 demonstrated demonstrate VBN cord-015021-pol2qm74 7869 12 to to TO cord-015021-pol2qm74 7869 13 increase increase VB cord-015021-pol2qm74 7869 14 survival survival NN cord-015021-pol2qm74 7869 15 in in IN cord-015021-pol2qm74 7869 16 patients patient NNS cord-015021-pol2qm74 7869 17 with with IN cord-015021-pol2qm74 7869 18 sepsis sepsis NN cord-015021-pol2qm74 7869 19 syndrome syndrome NN cord-015021-pol2qm74 7869 20 and and CC cord-015021-pol2qm74 7869 21 septic septic JJ cord-015021-pol2qm74 7869 22 shock shock NN cord-015021-pol2qm74 7869 23 in in IN cord-015021-pol2qm74 7869 24 a a DT cord-015021-pol2qm74 7869 25 dose dose NN cord-015021-pol2qm74 7869 26 - - HYPH cord-015021-pol2qm74 7869 27 dependent dependent JJ cord-015021-pol2qm74 7869 28 manner manner NN cord-015021-pol2qm74 7869 29 . . . cord-015021-pol2qm74 7870 1 Methods method NNS cord-015021-pol2qm74 7870 2 : : : cord-015021-pol2qm74 7870 3 A a DT cord-015021-pol2qm74 7870 4 randomized randomized JJ cord-015021-pol2qm74 7870 5 , , , cord-015021-pol2qm74 7870 6 double double JJ cord-015021-pol2qm74 7870 7 - - HYPH cord-015021-pol2qm74 7870 8 blind blind JJ cord-015021-pol2qm74 7870 9 , , , cord-015021-pol2qm74 7870 10 placebo placebo NN cord-015021-pol2qm74 7870 11 - - HYPH cord-015021-pol2qm74 7870 12 controlled control VBN cord-015021-pol2qm74 7870 13 , , , cord-015021-pol2qm74 7870 14 malticenter malticenter NNP cord-015021-pol2qm74 7870 15 , , , cord-015021-pol2qm74 7870 16 clinical clinical JJ cord-015021-pol2qm74 7870 17 trial trial NN cord-015021-pol2qm74 7870 18 enrolled enrol VBD cord-015021-pol2qm74 7870 19 893 893 CD cord-015021-pol2qm74 7870 20 patients patient NNS cord-015021-pol2qm74 7870 21 at at IN cord-015021-pol2qm74 7870 22 63 63 CD cord-015021-pol2qm74 7870 23 academic academic JJ cord-015021-pol2qm74 7870 24 medical medical JJ cord-015021-pol2qm74 7870 25 centers center NNS cord-015021-pol2qm74 7870 26 in in IN cord-015021-pol2qm74 7870 27 Europe Europe NNP cord-015021-pol2qm74 7870 28 aad aad NNP cord-015021-pol2qm74 7870 29 North North NNP cord-015021-pol2qm74 7870 30 America America NNP cord-015021-pol2qm74 7870 31 . . . cord-015021-pol2qm74 7871 1 Eligible eligible JJ cord-015021-pol2qm74 7871 2 patients patient NNS cord-015021-pol2qm74 7871 3 received receive VBD cord-015021-pol2qm74 7871 4 either either CC cord-015021-pol2qm74 7871 5 placebo placebo NN cord-015021-pol2qm74 7871 6 ( ( -LRB- cord-015021-pol2qm74 7871 7 vehicle vehicle NN cord-015021-pol2qm74 7871 8 ) ) -RRB- cord-015021-pol2qm74 7871 9 or or CC cord-015021-pol2qm74 7871 10 rhIL rhIL NNP cord-015021-pol2qm74 7871 11 - - HYPH cord-015021-pol2qm74 7871 12 lra lra NNP cord-015021-pol2qm74 7871 13 ( ( -LRB- cord-015021-pol2qm74 7871 14 anakinra anakinra NNP cord-015021-pol2qm74 7871 15 ) ) -RRB- cord-015021-pol2qm74 7871 16 1.0 1.0 CD cord-015021-pol2qm74 7871 17 or or CC cord-015021-pol2qm74 7871 18 2.0 2.0 CD cord-015021-pol2qm74 7871 19 mg mg NNP cord-015021-pol2qm74 7871 20 / / SYM cord-015021-pol2qm74 7871 21 kg kg NNP cord-015021-pol2qm74 7871 22 / / SYM cord-015021-pol2qm74 7871 23 hr hr NN cord-015021-pol2qm74 7871 24 by by IN cord-015021-pol2qm74 7871 25 continuous continuous JJ cord-015021-pol2qm74 7871 26 intravenous intravenous JJ cord-015021-pol2qm74 7871 27 infusion infusion NN cord-015021-pol2qm74 7871 28 for for IN cord-015021-pol2qm74 7871 29 72 72 CD cord-015021-pol2qm74 7871 30 hours hour NNS cord-015021-pol2qm74 7871 31 . . . cord-015021-pol2qm74 7872 1 The the DT cord-015021-pol2qm74 7872 2 presence presence NN cord-015021-pol2qm74 7872 3 of of IN cord-015021-pol2qm74 7872 4 organ organ NN cord-015021-pol2qm74 7872 5 dysfunction dysfunction NN cord-015021-pol2qm74 7872 6 ( ( -LRB- cord-015021-pol2qm74 7872 7 i.e. i.e. FW cord-015021-pol2qm74 7872 8 , , , cord-015021-pol2qm74 7872 9 ARDS ARDS NNP cord-015021-pol2qm74 7872 10 , , , cord-015021-pol2qm74 7872 11 DIC DIC NNP cord-015021-pol2qm74 7872 12 , , , cord-015021-pol2qm74 7872 13 renal renal JJ cord-015021-pol2qm74 7872 14 , , , cord-015021-pol2qm74 7872 15 and and CC cord-015021-pol2qm74 7872 16 hepatic hepatic JJ cord-015021-pol2qm74 7872 17 ) ) -RRB- cord-015021-pol2qm74 7872 18 at at IN cord-015021-pol2qm74 7872 19 study study NN cord-015021-pol2qm74 7872 20 entry entry NN cord-015021-pol2qm74 7872 21 was be VBD cord-015021-pol2qm74 7872 22 determined determine VBN cord-015021-pol2qm74 7872 23 prospectively prospectively RB cord-015021-pol2qm74 7872 24 by by IN cord-015021-pol2qm74 7872 25 a a DT cord-015021-pol2qm74 7872 26 Clinical Clinical NNP cord-015021-pol2qm74 7872 27 Evaluation Evaluation NNP cord-015021-pol2qm74 7872 28 Committee Committee NNP cord-015021-pol2qm74 7872 29 using use VBG cord-015021-pol2qm74 7872 30 definitions definition NNS cord-015021-pol2qm74 7872 31 which which WDT cord-015021-pol2qm74 7872 32 were be VBD cord-015021-pol2qm74 7872 33 developed develop VBN cord-015021-pol2qm74 7872 34 a a DT cord-015021-pol2qm74 7872 35 - - HYPH cord-015021-pol2qm74 7872 36 priori priori FW cord-015021-pol2qm74 7872 37 . . . cord-015021-pol2qm74 7873 1 Survival survival NN cord-015021-pol2qm74 7873 2 time time NN cord-015021-pol2qm74 7873 3 was be VBD cord-015021-pol2qm74 7873 4 evaluated evaluate VBN cord-015021-pol2qm74 7873 5 over over IN cord-015021-pol2qm74 7873 6 28 28 CD cord-015021-pol2qm74 7873 7 days day NNS cord-015021-pol2qm74 7873 8 utilizing utilize VBG cord-015021-pol2qm74 7873 9 a a DT cord-015021-pol2qm74 7873 10 linear linear JJ cord-015021-pol2qm74 7873 11 dose dose JJ cord-015021-pol2qm74 7873 12 - - HYPH cord-015021-pol2qm74 7873 13 response response NN cord-015021-pol2qm74 7873 14 model model NN cord-015021-pol2qm74 7873 15 , , , cord-015021-pol2qm74 7873 16 assuming assume VBG cord-015021-pol2qm74 7873 17 a a DT cord-015021-pol2qm74 7873 18 log log NN cord-015021-pol2qm74 7873 19 - - HYPH cord-015021-pol2qm74 7873 20 normal normal JJ cord-015021-pol2qm74 7873 21 distribution distribution NN cord-015021-pol2qm74 7873 22 . . . cord-015021-pol2qm74 7874 1 Results result NNS cord-015021-pol2qm74 7874 2 : : : cord-015021-pol2qm74 7875 1 563 563 CD cord-015021-pol2qm74 7875 2 patients patient NNS cord-015021-pol2qm74 7875 3 had have VBD cord-015021-pol2qm74 7875 4 one one CD cord-015021-pol2qm74 7875 5 or or CC cord-015021-pol2qm74 7875 6 more more JJR cord-015021-pol2qm74 7875 7 sepsis sepsis NN cord-015021-pol2qm74 7875 8 - - HYPH cord-015021-pol2qm74 7875 9 induced induce VBN cord-015021-pol2qm74 7875 10 organ organ NN cord-015021-pol2qm74 7875 11 dysfunction(s dysfunction(s NNP cord-015021-pol2qm74 7875 12 ) ) -RRB- cord-015021-pol2qm74 7875 13 at at IN cord-015021-pol2qm74 7875 14 study study NN cord-015021-pol2qm74 7875 15 entry entry NN cord-015021-pol2qm74 7875 16 . . . cord-015021-pol2qm74 7876 1 A a DT cord-015021-pol2qm74 7876 2 dose dose NN cord-015021-pol2qm74 7876 3 - - HYPH cord-015021-pol2qm74 7876 4 related relate VBN cord-015021-pol2qm74 7876 5 increase increase NN cord-015021-pol2qm74 7876 6 in in IN cord-015021-pol2qm74 7876 7 survival survival NN cord-015021-pol2qm74 7876 8 time time NN cord-015021-pol2qm74 7876 9 was be VBD cord-015021-pol2qm74 7876 10 observed observe VBN cord-015021-pol2qm74 7876 11 with with IN cord-015021-pol2qm74 7876 12 rhlL rhlL NNP cord-015021-pol2qm74 7876 13 - - HYPH cord-015021-pol2qm74 7876 14 lra lra NNP cord-015021-pol2qm74 7876 15 compared compare VBN cord-015021-pol2qm74 7876 16 to to IN cord-015021-pol2qm74 7876 17 placebo placebo NN cord-015021-pol2qm74 7876 18 in in IN cord-015021-pol2qm74 7876 19 patients patient NNS cord-015021-pol2qm74 7876 20 with with IN cord-015021-pol2qm74 7876 21 ARDS ARDS NNP cord-015021-pol2qm74 7876 22 , , , cord-015021-pol2qm74 7876 23 DIC DIC NNP cord-015021-pol2qm74 7876 24 , , , cord-015021-pol2qm74 7876 25 and and CC cord-015021-pol2qm74 7876 26 renal renal JJ cord-015021-pol2qm74 7876 27 dysfunction dysfunction NN cord-015021-pol2qm74 7876 28 ( ( -LRB- cord-015021-pol2qm74 7876 29 P p NN cord-015021-pol2qm74 7876 30 -- -- : cord-015021-pol2qm74 7876 31 < < XX cord-015021-pol2qm74 7876 32 0.04 0.04 CD cord-015021-pol2qm74 7876 33 Endotoxin endotoxin NN cord-015021-pol2qm74 7876 34 infusion infusion NN cord-015021-pol2qm74 7876 35 releases release VBZ cord-015021-pol2qm74 7876 36 platelet platelet NN cord-015021-pol2qm74 7876 37 - - HYPH cord-015021-pol2qm74 7876 38 activating activate VBG cord-015021-pol2qm74 7876 39 factor factor NN cord-015021-pol2qm74 7876 40 ( ( -LRB- cord-015021-pol2qm74 7876 41 PAF PAF NNP cord-015021-pol2qm74 7876 42 ) ) -RRB- cord-015021-pol2qm74 7876 43 , , , cord-015021-pol2qm74 7876 44 a a DT cord-015021-pol2qm74 7876 45 potent potent JJ cord-015021-pol2qm74 7876 46 phospholipid phospholipid NN cord-015021-pol2qm74 7876 47 mediator mediator NN cord-015021-pol2qm74 7876 48 which which WDT cord-015021-pol2qm74 7876 49 leads lead VBZ cord-015021-pol2qm74 7876 50 to to IN cord-015021-pol2qm74 7876 51 an an DT cord-015021-pol2qm74 7876 52 autocatalytic autocatalytic JJ cord-015021-pol2qm74 7876 53 amplification amplification NN cord-015021-pol2qm74 7876 54 of of IN cord-015021-pol2qm74 7876 55 cytokine cytokine NN cord-015021-pol2qm74 7876 56 release release NN cord-015021-pol2qm74 7876 57 . . . cord-015021-pol2qm74 7877 1 BN BN NNP cord-015021-pol2qm74 7877 2 52021 52021 CD cord-015021-pol2qm74 7877 3 ( ( -LRB- cord-015021-pol2qm74 7877 4 Ginkgolide Ginkgolide NNP cord-015021-pol2qm74 7877 5 B B NNP cord-015021-pol2qm74 7877 6 ) ) -RRB- cord-015021-pol2qm74 7877 7 , , , cord-015021-pol2qm74 7877 8 a a DT cord-015021-pol2qm74 7877 9 natural natural JJ cord-015021-pol2qm74 7877 10 PAF PAF NNP cord-015021-pol2qm74 7877 11 receptor receptor NN cord-015021-pol2qm74 7877 12 antagonist antagonist NN cord-015021-pol2qm74 7877 13 , , , cord-015021-pol2qm74 7877 14 has have VBZ cord-015021-pol2qm74 7877 15 provided provide VBN cord-015021-pol2qm74 7877 16 significant significant JJ cord-015021-pol2qm74 7877 17 protection protection NN cord-015021-pol2qm74 7877 18 against against IN cord-015021-pol2qm74 7877 19 sepsis sepsis NN cord-015021-pol2qm74 7877 20 in in IN cord-015021-pol2qm74 7877 21 different different JJ cord-015021-pol2qm74 7877 22 animal animal NN cord-015021-pol2qm74 7877 23 models• models• . cord-015021-pol2qm74 7878 1 A a DT cord-015021-pol2qm74 7878 2 randomized randomized JJ cord-015021-pol2qm74 7878 3 , , , cord-015021-pol2qm74 7878 4 placebo placebo NN cord-015021-pol2qm74 7878 5 - - HYPH cord-015021-pol2qm74 7878 6 controlled control VBN cord-015021-pol2qm74 7878 7 , , , cord-015021-pol2qm74 7878 8 double double RB cord-015021-pol2qm74 7878 9 blind blind JJ cord-015021-pol2qm74 7878 10 , , , cord-015021-pol2qm74 7878 11 multicenter multicenter JJ cord-015021-pol2qm74 7878 12 trial trial NN cord-015021-pol2qm74 7878 13 on on IN cord-015021-pol2qm74 7878 14 efficacy efficacy NN cord-015021-pol2qm74 7879 1 ( ( -LRB- cord-015021-pol2qm74 7879 2 mortality mortality NN cord-015021-pol2qm74 7879 3 at at IN cord-015021-pol2qm74 7879 4 D28 D28 NNP cord-015021-pol2qm74 7879 5 ) ) -RRB- cord-015021-pol2qm74 7879 6 and and CC cord-015021-pol2qm74 7879 7 tolerance tolerance NN cord-015021-pol2qm74 7879 8 of of IN cord-015021-pol2qm74 7879 9 BN BN NNP cord-015021-pol2qm74 7879 10 52021 52021 CD cord-015021-pol2qm74 7879 11 ( ( -LRB- cord-015021-pol2qm74 7879 12 2 2 CD cord-015021-pol2qm74 7879 13 IV IV NNP cord-015021-pol2qm74 7879 14 infusion infusion NN cord-015021-pol2qm74 7879 15 of of IN cord-015021-pol2qm74 7879 16 120 120 CD cord-015021-pol2qm74 7879 17 mg mg NN cord-015021-pol2qm74 7879 18 x x SYM cord-015021-pol2qm74 7879 19 2 2 CD cord-015021-pol2qm74 7879 20 / / SYM cord-015021-pol2qm74 7879 21 day day NN cord-015021-pol2qm74 7879 22 over over IN cord-015021-pol2qm74 7879 23 4 4 CD cord-015021-pol2qm74 7879 24 days day NNS cord-015021-pol2qm74 7879 25 ) ) -RRB- cord-015021-pol2qm74 7879 26 in in IN cord-015021-pol2qm74 7879 27 severe severe JJ cord-015021-pol2qm74 7879 28 sepsis sepsis NN cord-015021-pol2qm74 7879 29 has have VBZ cord-015021-pol2qm74 7879 30 enrolled enrol VBN cord-015021-pol2qm74 7879 31 262 262 CD cord-015021-pol2qm74 7879 32 pts pt NNS cord-015021-pol2qm74 7879 33 . . . cord-015021-pol2qm74 7880 1 The the DT cord-015021-pol2qm74 7880 2 28day 28day NN cord-015021-pol2qm74 7880 3 mortality mortality NN cord-015021-pol2qm74 7880 4 rate rate NN cord-015021-pol2qm74 7880 5 was be VBD cord-015021-pol2qm74 7880 6 51 51 CD cord-015021-pol2qm74 7880 7 % % NN cord-015021-pol2qm74 7880 8 for for IN cord-015021-pol2qm74 7880 9 the the DT cord-015021-pol2qm74 7880 10 placebo placebo NN cord-015021-pol2qm74 7880 11 group group NN cord-015021-pol2qm74 7880 12 and and CC cord-015021-pol2qm74 7880 13 42 42 CD cord-015021-pol2qm74 7880 14 % % NN cord-015021-pol2qm74 7880 15 for for IN cord-015021-pol2qm74 7880 16 the the DT cord-015021-pol2qm74 7880 17 BN BN NNP cord-015021-pol2qm74 7880 18 52021 52021 CD cord-015021-pol2qm74 7880 19 group group NN cord-015021-pol2qm74 7880 20 ( ( -LRB- cord-015021-pol2qm74 7880 21 P p NN cord-015021-pol2qm74 7880 22 = = SYM cord-015021-pol2qm74 7880 23 .17 .17 CD cord-015021-pol2qm74 7880 24 ) ) -RRB- cord-015021-pol2qm74 7880 25 . . . cord-015021-pol2qm74 7881 1 The the DT cord-015021-pol2qm74 7881 2 efficacy efficacy NN cord-015021-pol2qm74 7881 3 of of IN cord-015021-pol2qm74 7881 4 BN BN NNP cord-015021-pol2qm74 7881 5 52021 52021 CD cord-015021-pol2qm74 7881 6 was be VBD cord-015021-pol2qm74 7881 7 greater great JJR cord-015021-pol2qm74 7881 8 in in IN cord-015021-pol2qm74 7881 9 pts pts NN cord-015021-pol2qm74 7881 10 with with IN cord-015021-pol2qm74 7881 11 gram gram JJ cord-015021-pol2qm74 7881 12 - - HYPH cord-015021-pol2qm74 7881 13 negative negative JJ cord-015021-pol2qm74 7881 14 sepsis sepsis NN cord-015021-pol2qm74 7881 15 : : : cord-015021-pol2qm74 7881 16 the the DT cord-015021-pol2qm74 7881 17 28-day 28-day CD cord-015021-pol2qm74 7881 18 mortality mortality NN cord-015021-pol2qm74 7881 19 rate rate NN cord-015021-pol2qm74 7881 20 was be VBD cord-015021-pol2qm74 7881 21 57 57 CD cord-015021-pol2qm74 7881 22 % % NN cord-015021-pol2qm74 7881 23 for for IN cord-015021-pol2qm74 7881 24 the the DT cord-015021-pol2qm74 7881 25 placebo placebo NN cord-015021-pol2qm74 7881 26 group group NN cord-015021-pol2qm74 7881 27 and and CC cord-015021-pol2qm74 7881 28 33 33 CD cord-015021-pol2qm74 7881 29 % % NN cord-015021-pol2qm74 7881 30 for for IN cord-015021-pol2qm74 7881 31 the the DT cord-015021-pol2qm74 7881 32 BN BN NNP cord-015021-pol2qm74 7881 33 52021 52021 CD cord-015021-pol2qm74 7881 34 group group NN cord-015021-pol2qm74 7881 35 ( ( -LRB- cord-015021-pol2qm74 7881 36 P p NN cord-015021-pol2qm74 7881 37 = = SYM cord-015021-pol2qm74 7881 38 .01 .01 NFP cord-015021-pol2qm74 7881 39 ) ) -RRB- cord-015021-pol2qm74 7881 40 . . . cord-015021-pol2qm74 7882 1 BN BN NNP cord-015021-pol2qm74 7882 2 52021 52021 CD cord-015021-pol2qm74 7882 3 also also RB cord-015021-pol2qm74 7882 4 reduced reduce VBD cord-015021-pol2qm74 7882 5 mortality mortality NN cord-015021-pol2qm74 7882 6 among among IN cord-015021-pol2qm74 7882 7 pts pt NNS cord-015021-pol2qm74 7882 8 with with IN cord-015021-pol2qm74 7882 9 gram gram JJ cord-015021-pol2qm74 7882 10 - - HYPH cord-015021-pol2qm74 7882 11 negative negative JJ cord-015021-pol2qm74 7882 12 septic septic JJ cord-015021-pol2qm74 7882 13 shock shock NN cord-015021-pol2qm74 7882 14 ( ( -LRB- cord-015021-pol2qm74 7882 15 mortality mortality NN cord-015021-pol2qm74 7882 16 was be VBD cord-015021-pol2qm74 7882 17 65 65 CD cord-015021-pol2qm74 7882 18 % % NN cord-015021-pol2qm74 7882 19 for for IN cord-015021-pol2qm74 7882 20 placebo placebo NN cord-015021-pol2qm74 7882 21 vs vs IN cord-015021-pol2qm74 7882 22 37 37 CD cord-015021-pol2qm74 7882 23 % % NN cord-015021-pol2qm74 7882 24 for for IN cord-015021-pol2qm74 7882 25 BN BN NNP cord-015021-pol2qm74 7882 26 52021 52021 CD cord-015021-pol2qm74 7882 27 ; ; : cord-015021-pol2qm74 7882 28 P p NN cord-015021-pol2qm74 7882 29 = = SYM cord-015021-pol2qm74 7882 30 .01 .01 NFP cord-015021-pol2qm74 7882 31 ) ) -RRB- cord-015021-pol2qm74 7882 32 . . . cord-015021-pol2qm74 7883 1 Using use VBG cord-015021-pol2qm74 7883 2 statistical statistical JJ cord-015021-pol2qm74 7883 3 adjusments adjusment NNS cord-015021-pol2qm74 7883 4 for for IN cord-015021-pol2qm74 7883 5 pronostic pronostic JJ cord-015021-pol2qm74 7883 6 factors factor NNS cord-015021-pol2qm74 7883 7 , , , cord-015021-pol2qm74 7883 8 the the DT cord-015021-pol2qm74 7883 9 relative relative JJ cord-015021-pol2qm74 7883 10 risk risk NN cord-015021-pol2qm74 7883 11 of of IN cord-015021-pol2qm74 7883 12 death death NN cord-015021-pol2qm74 7883 13 of of IN cord-015021-pol2qm74 7883 14 the the DT cord-015021-pol2qm74 7883 15 BN BN NNP cord-015021-pol2qm74 7883 16 52021 52021 CD cord-015021-pol2qm74 7883 17 group group NN cord-015021-pol2qm74 7883 18 was be VBD cord-015021-pol2qm74 7883 19 0.61 0.61 CD cord-015021-pol2qm74 7883 20 ( ( -LRB- cord-015021-pol2qm74 7883 21 0.34 0.34 CD cord-015021-pol2qm74 7883 22 -1.08 -1.08 CD cord-015021-pol2qm74 7883 23 , , , cord-015021-pol2qm74 7883 24 95 95 CD cord-015021-pol2qm74 7883 25 % % NN cord-015021-pol2qm74 7883 26 confidence confidence NN cord-015021-pol2qm74 7883 27 interval interval NN cord-015021-pol2qm74 7883 28 ; ; : cord-015021-pol2qm74 7883 29 P p NN cord-015021-pol2qm74 7883 30 = = SYM cord-015021-pol2qm74 7883 31 .09 .09 CD cord-015021-pol2qm74 7883 32 ) ) -RRB- cord-015021-pol2qm74 7883 33 . . . cord-015021-pol2qm74 7884 1 This this DT cord-015021-pol2qm74 7884 2 risk risk NN cord-015021-pol2qm74 7884 3 corresponds correspond VBZ cord-015021-pol2qm74 7884 4 to to IN cord-015021-pol2qm74 7884 5 an an DT cord-015021-pol2qm74 7884 6 adjusted adjust VBN cord-015021-pol2qm74 7884 7 reduction reduction NN cord-015021-pol2qm74 7884 8 in in IN cord-015021-pol2qm74 7884 9 mortality mortality NN cord-015021-pol2qm74 7884 10 of of IN cord-015021-pol2qm74 7884 11 39 39 CD cord-015021-pol2qm74 7884 12 % % NN cord-015021-pol2qm74 7884 13 for for IN cord-015021-pol2qm74 7884 14 pts pt NNS cord-015021-pol2qm74 7884 15 receiving receive VBG cord-015021-pol2qm74 7884 16 BN BN NNP cord-015021-pol2qm74 7884 17 52021 52021 CD cord-015021-pol2qm74 7884 18 . . . cord-015021-pol2qm74 7885 1 No no DT cord-015021-pol2qm74 7885 2 differences difference NNS cord-015021-pol2qm74 7885 3 in in IN cord-015021-pol2qm74 7885 4 mortality mortality NN cord-015021-pol2qm74 7885 5 rates rate NNS cord-015021-pol2qm74 7885 6 were be VBD cord-015021-pol2qm74 7885 7 found find VBN cord-015021-pol2qm74 7885 8 between between IN cord-015021-pol2qm74 7885 9 the the DT cord-015021-pol2qm74 7885 10 placebo placebo NN cord-015021-pol2qm74 7885 11 and and CC cord-015021-pol2qm74 7885 12 the the DT cord-015021-pol2qm74 7885 13 BN BN NNP cord-015021-pol2qm74 7885 14 52021 52021 CD cord-015021-pol2qm74 7885 15 groups group NNS cord-015021-pol2qm74 7885 16 in in IN cord-015021-pol2qm74 7885 17 the the DT cord-015021-pol2qm74 7885 18 absence absence NN cord-015021-pol2qm74 7885 19 of of IN cord-015021-pol2qm74 7885 20 gram gram NN cord-015021-pol2qm74 7885 21 - - HYPH cord-015021-pol2qm74 7885 22 negative negative JJ cord-015021-pol2qm74 7885 23 sepsis• sepsis• XX cord-015021-pol2qm74 7886 1 There there EX cord-015021-pol2qm74 7886 2 were be VBD cord-015021-pol2qm74 7886 3 no no DT cord-015021-pol2qm74 7886 4 differences difference NNS cord-015021-pol2qm74 7886 5 in in IN cord-015021-pol2qm74 7886 6 adverse adverse JJ cord-015021-pol2qm74 7886 7 events event NNS cord-015021-pol2qm74 7886 8 between between IN cord-015021-pol2qm74 7886 9 the the DT cord-015021-pol2qm74 7886 10 placebo placebo NN cord-015021-pol2qm74 7886 11 and and CC cord-015021-pol2qm74 7886 12 the the DT cord-015021-pol2qm74 7886 13 BN BN NNP cord-015021-pol2qm74 7886 14 52021 52021 CD cord-015021-pol2qm74 7886 15 groups group NNS cord-015021-pol2qm74 7886 16 . . . cord-015021-pol2qm74 7887 1 BN BN NNP cord-015021-pol2qm74 7887 2 52021 52021 CD cord-015021-pol2qm74 7887 3 is be VBZ cord-015021-pol2qm74 7887 4 a a DT cord-015021-pol2qm74 7887 5 safe safe JJ cord-015021-pol2qm74 7887 6 and and CC cord-015021-pol2qm74 7887 7 promising promising JJ cord-015021-pol2qm74 7887 8 treatment treatment NN cord-015021-pol2qm74 7887 9 for for IN cord-015021-pol2qm74 7887 10 patients patient NNS cord-015021-pol2qm74 7887 11 with with IN cord-015021-pol2qm74 7887 12 severe severe JJ cord-015021-pol2qm74 7887 13 gram gram NN cord-015021-pol2qm74 7887 14 - - HYPH cord-015021-pol2qm74 7887 15 negative negative JJ cord-015021-pol2qm74 7887 16 sepsis sepsis NN cord-015021-pol2qm74 7887 17 . . . cord-015021-pol2qm74 7888 1 A a DT cord-015021-pol2qm74 7888 2 confirming confirm VBG cord-015021-pol2qm74 7888 3 study study NN cord-015021-pol2qm74 7888 4 , , , cord-015021-pol2qm74 7888 5 focused focus VBD cord-015021-pol2qm74 7888 6 on on IN cord-015021-pol2qm74 7888 7 gram gram NN cord-015021-pol2qm74 7888 8 negative negative JJ cord-015021-pol2qm74 7888 9 sepsis sepsis NN cord-015021-pol2qm74 7888 10 , , , cord-015021-pol2qm74 7888 11 is be VBZ cord-015021-pol2qm74 7888 12 In in IN cord-015021-pol2qm74 7888 13 progress progress NN cord-015021-pol2qm74 7888 14 . . . cord-015021-pol2qm74 7889 1 V~3lliam V~3lliam NNP cord-015021-pol2qm74 7889 2 A. a. NN cord-015021-pol2qm74 7889 3 Kanus Kanus NNP cord-015021-pol2qm74 7889 4 M.D. M.D. NNP cord-015021-pol2qm74 7889 5 and and CC cord-015021-pol2qm74 7889 6 The the DT cord-015021-pol2qm74 7889 7 rhlL rhlL NNP cord-015021-pol2qm74 7889 8 - - HYPH cord-015021-pol2qm74 7889 9 lra lra NNP cord-015021-pol2qm74 7890 1 It -PRON- PRP cord-015021-pol2qm74 7890 2 has have VBZ cord-015021-pol2qm74 7890 3 been be VBN cord-015021-pol2qm74 7890 4 traditional traditional JJ cord-015021-pol2qm74 7890 5 within within IN cord-015021-pol2qm74 7890 6 the the DT cord-015021-pol2qm74 7890 7 field field NN cord-015021-pol2qm74 7890 8 of of IN cord-015021-pol2qm74 7890 9 infection infection NN cord-015021-pol2qm74 7890 10 and and CC cord-015021-pol2qm74 7890 11 sepsis sepsis NN cord-015021-pol2qm74 7890 12 to to TO cord-015021-pol2qm74 7890 13 think think VB cord-015021-pol2qm74 7890 14 in in IN cord-015021-pol2qm74 7890 15 terms term NNS cord-015021-pol2qm74 7890 16 of of IN cord-015021-pol2qm74 7890 17 specific specific JJ cord-015021-pol2qm74 7890 18 indications indication NNS cord-015021-pol2qm74 7890 19 for for IN cord-015021-pol2qm74 7890 20 drugs drug NNS cord-015021-pol2qm74 7890 21 based base VBN cord-015021-pol2qm74 7890 22 on on IN cord-015021-pol2qm74 7890 23 the the DT cord-015021-pol2qm74 7890 24 type type NN cord-015021-pol2qm74 7890 25 of of IN cord-015021-pol2qm74 7890 26 infecting infect VBG cord-015021-pol2qm74 7890 27 organisms organism NNS cord-015021-pol2qm74 7890 28 , , , cord-015021-pol2qm74 7890 29 Advances advance NNS cord-015021-pol2qm74 7890 30 in in IN cord-015021-pol2qm74 7890 31 antibiotic antibiotic JJ cord-015021-pol2qm74 7890 32 therapy therapy NN cord-015021-pol2qm74 7890 33 now now RB cord-015021-pol2qm74 7890 34 control control VBP cord-015021-pol2qm74 7890 35 or or CC cord-015021-pol2qm74 7890 36 ltnflt ltnflt VBD cord-015021-pol2qm74 7890 37 the the DT cord-015021-pol2qm74 7890 38 growth growth NN cord-015021-pol2qm74 7890 39 of of IN cord-015021-pol2qm74 7890 40 bacteria bacteria NNS cord-015021-pol2qm74 7890 41 . . . cord-015021-pol2qm74 7891 1 The the DT cord-015021-pol2qm74 7891 2 majority majority NN cord-015021-pol2qm74 7891 3 of of IN cord-015021-pol2qm74 7891 4 deaths death NNS cord-015021-pol2qm74 7891 5 are be VBP cord-015021-pol2qm74 7891 6 now now RB cord-015021-pol2qm74 7891 7 caused cause VBN cord-015021-pol2qm74 7891 8 by by IN cord-015021-pol2qm74 7891 9 either either CC cord-015021-pol2qm74 7891 10 an an DT cord-015021-pol2qm74 7891 11 initial initial JJ cord-015021-pol2qm74 7891 12 overwhelming overwhelming JJ cord-015021-pol2qm74 7891 13 response response NN cord-015021-pol2qm74 7891 14 to to IN cord-015021-pol2qm74 7891 15 infection infection NN cord-015021-pol2qm74 7891 16 or or CC cord-015021-pol2qm74 7891 17 subsequent subsequent JJ cord-015021-pol2qm74 7891 18 multiple multiple JJ cord-015021-pol2qm74 7891 19 organ organ NN cord-015021-pol2qm74 7891 20 system system NN cord-015021-pol2qm74 7891 21 failure failure NN cord-015021-pol2qm74 7891 22 attributed attribute VBN cord-015021-pol2qm74 7891 23 , , , cord-015021-pol2qm74 7891 24 in in IN cord-015021-pol2qm74 7891 25 part part NN cord-015021-pol2qm74 7891 26 , , , cord-015021-pol2qm74 7891 27 to to IN cord-015021-pol2qm74 7891 28 the the DT cord-015021-pol2qm74 7891 29 effects effect NNS cord-015021-pol2qm74 7891 30 of of IN cord-015021-pol2qm74 7891 31 intrinsic intrinsic JJ cord-015021-pol2qm74 7891 32 biologic biologic JJ cord-015021-pol2qm74 7891 33 responses response NNS cord-015021-pol2qm74 7891 34 of of IN cord-015021-pol2qm74 7891 35 the the DT cord-015021-pol2qm74 7891 36 host host NN cord-015021-pol2qm74 7891 37 . . . cord-015021-pol2qm74 7892 1 Type type NN cord-015021-pol2qm74 7892 2 of of IN cord-015021-pol2qm74 7892 3 organism organism NN cord-015021-pol2qm74 7892 4 , , , cord-015021-pol2qm74 7892 5 therefore therefore RB cord-015021-pol2qm74 7892 6 , , , cord-015021-pol2qm74 7892 7 may may MD cord-015021-pol2qm74 7892 8 not not RB cord-015021-pol2qm74 7892 9 be be VB cord-015021-pol2qm74 7892 10 as as RB cord-015021-pol2qm74 7892 11 critical critical JJ cord-015021-pol2qm74 7892 12 as as IN cord-015021-pol2qm74 7892 13 determining determine VBG cord-015021-pol2qm74 7892 14 the the DT cord-015021-pol2qm74 7892 15 exact exact JJ cord-015021-pol2qm74 7892 16 severity severity NN cord-015021-pol2qm74 7892 17 of of IN cord-015021-pol2qm74 7892 18 the the DT cord-015021-pol2qm74 7892 19 host host NN cord-015021-pol2qm74 7892 20 's 's POS cord-015021-pol2qm74 7892 21 severity severity NN cord-015021-pol2qm74 7892 22 or or CC cord-015021-pol2qm74 7892 23 risk risk NN cord-015021-pol2qm74 7892 24 of of IN cord-015021-pol2qm74 7892 25 death death NN cord-015021-pol2qm74 7892 26 from from IN cord-015021-pol2qm74 7892 27 infection infection NN cord-015021-pol2qm74 7892 28 . . . cord-015021-pol2qm74 7893 1 We -PRON- PRP cord-015021-pol2qm74 7893 2 also also RB cord-015021-pol2qm74 7893 3 know know VBP cord-015021-pol2qm74 7893 4 that that IN cord-015021-pol2qm74 7893 5 both both CC cord-015021-pol2qm74 7893 6 the the DT cord-015021-pol2qm74 7893 7 relative relative JJ cord-015021-pol2qm74 7893 8 benefit benefit NN cord-015021-pol2qm74 7893 9 of of IN cord-015021-pol2qm74 7893 10 a a DT cord-015021-pol2qm74 7893 11 new new JJ cord-015021-pol2qm74 7893 12 treatment treatment NN cord-015021-pol2qm74 7893 13 across across IN cord-015021-pol2qm74 7893 14 groups group NNS cord-015021-pol2qm74 7893 15 and and CC cord-015021-pol2qm74 7893 16 its -PRON- PRP$ cord-015021-pol2qm74 7893 17 absolute absolute JJ cord-015021-pol2qm74 7893 18 benefit benefit NN cord-015021-pol2qm74 7893 19 for for IN cord-015021-pol2qm74 7893 20 an an DT cord-015021-pol2qm74 7893 21 Individual individual JJ cord-015021-pol2qm74 7893 22 patient patient NN cord-015021-pol2qm74 7893 23 will will MD cord-015021-pol2qm74 7893 24 vary vary VB cord-015021-pol2qm74 7893 25 with with IN cord-015021-pol2qm74 7893 26 their -PRON- PRP$ cord-015021-pol2qm74 7893 27 risk risk NN cord-015021-pol2qm74 7893 28 in in IN cord-015021-pol2qm74 7893 29 a a DT cord-015021-pol2qm74 7893 30 predictable predictable JJ cord-015021-pol2qm74 7893 31 fashion fashion NN cord-015021-pol2qm74 7893 32 . . . cord-015021-pol2qm74 7894 1 We -PRON- PRP cord-015021-pol2qm74 7894 2 recently recently RB cord-015021-pol2qm74 7894 3 iuve iuve VBD cord-015021-pol2qm74 7894 4 ~ ~ NFP cord-015021-pol2qm74 7894 5 iguted igute VBD cord-015021-pol2qm74 7894 6 the the DT cord-015021-pol2qm74 7894 7 relationship relationship NN cord-015021-pol2qm74 7894 8 between between IN cord-015021-pol2qm74 7894 9 one one CD cord-015021-pol2qm74 7894 10 measure measure NN cord-015021-pol2qm74 7894 11 of of IN cord-015021-pol2qm74 7894 12 host host NN cord-015021-pol2qm74 7894 13 response response NN cord-015021-pol2qm74 7894 14 , , , cord-015021-pol2qm74 7894 15 the the DT cord-015021-pol2qm74 7894 16 acute acute JJ cord-015021-pol2qm74 7894 17 risk risk NN cord-015021-pol2qm74 7894 18 of of IN cord-015021-pol2qm74 7894 19 death death NN cord-015021-pol2qm74 7894 20 as as IN cord-015021-pol2qm74 7894 21 prospectively prospectively RB cord-015021-pol2qm74 7894 22 estimated estimate VBN cord-015021-pol2qm74 7894 23 by by IN cord-015021-pol2qm74 7894 24 u u NNP cord-015021-pol2qm74 7894 25 comprehensive comprehensive JJ cord-015021-pol2qm74 7894 26 risk risk NN cord-015021-pol2qm74 7894 27 mode mode NN cord-015021-pol2qm74 7894 28 [ [ -LRB- cord-015021-pol2qm74 7894 29 for for IN cord-015021-pol2qm74 7894 30 28-day 28-day CD cord-015021-pol2qm74 7894 31 mortality mortality NN cord-015021-pol2qm74 7894 32 ( ( -LRB- cord-015021-pol2qm74 7894 33 JAMb JAMb NNP cord-015021-pol2qm74 7894 34 . . . cord-015021-pol2qm74 7894 35 1993 1993 CD cord-015021-pol2qm74 7894 36 ; ; : cord-015021-pol2qm74 7894 37 270:12,33 270:12,33 CD cord-015021-pol2qm74 7894 38 - - HYPH cord-015021-pol2qm74 7894 39 1241 1241 CD cord-015021-pol2qm74 7894 40 ) ) -RRB- cord-015021-pol2qm74 7894 41 , , , cord-015021-pol2qm74 7894 42 by by IN cord-015021-pol2qm74 7894 43 its -PRON- PRP$ cord-015021-pol2qm74 7894 44 retrospective retrospective JJ cord-015021-pol2qm74 7894 45 application application NN cord-015021-pol2qm74 7894 46 to to IN cord-015021-pol2qm74 7894 47 the the DT cord-015021-pol2qm74 7894 48 results result NNS cord-015021-pol2qm74 7894 49 from from IN cord-015021-pol2qm74 7894 50 the the DT cord-015021-pol2qm74 7894 51 Phase phase NN cord-015021-pol2qm74 7895 1 In in IN cord-015021-pol2qm74 7895 2 evaluation evaluation NN cord-015021-pol2qm74 7895 3 of of IN cord-015021-pol2qm74 7895 4 recombinant recombinant JJ cord-015021-pol2qm74 7895 5 human human NN cord-015021-pol2qm74 7895 6 intcrlenkin-1 intcrlenkin-1 NNP cord-015021-pol2qm74 7895 7 receptor receptor NN cord-015021-pol2qm74 7895 8 antagonist antagonist NN cord-015021-pol2qm74 7895 9 ( ( -LRB- cord-015021-pol2qm74 7895 10 rhlL. rhlL. NNP cord-015021-pol2qm74 7895 11 Ira Ira NNP cord-015021-pol2qm74 7895 12 ) ) -RRB- cord-015021-pol2qm74 7895 13 . . . cord-015021-pol2qm74 7896 1 We -PRON- PRP cord-015021-pol2qm74 7896 2 found find VBD cord-015021-pol2qm74 7896 3 that that IN cord-015021-pol2qm74 7896 4 there there EX cord-015021-pol2qm74 7896 5 was be VBD cord-015021-pol2qm74 7896 6 a a DT cord-015021-pol2qm74 7896 7 significant significant JJ cord-015021-pol2qm74 7896 8 interaction interaction NN cord-015021-pol2qm74 7896 9 between between IN cord-015021-pol2qm74 7896 10 the the DT cord-015021-pol2qm74 7896 11 patient patient NN cord-015021-pol2qm74 7896 12 's 's POS cord-015021-pol2qm74 7896 13 predicted predict VBN cord-015021-pol2qm74 7896 14 risk risk NN cord-015021-pol2qm74 7896 15 of of IN cord-015021-pol2qm74 7896 16 mortality mortality NN cord-015021-pol2qm74 7896 17 at at IN cord-015021-pol2qm74 7896 18 the the DT cord-015021-pol2qm74 7896 19 time time NN cord-015021-pol2qm74 7896 20 of of IN cord-015021-pol2qm74 7896 21 entry entry NN cord-015021-pol2qm74 7896 22 to to IN cord-015021-pol2qm74 7896 23 the the DT cord-015021-pol2qm74 7896 24 study study NN cord-015021-pol2qm74 7896 25 and and CC cord-015021-pol2qm74 7896 26 the the DT cord-015021-pol2qm74 7896 27 ability ability NN cord-015021-pol2qm74 7896 28 of of IN cord-015021-pol2qm74 7896 29 rhIL rhIL NNP cord-015021-pol2qm74 7896 30 - - HYPH cord-015021-pol2qm74 7896 31 lra lra NNP cord-015021-pol2qm74 7896 32 to to TO cord-015021-pol2qm74 7896 33 prolong prolong VB cord-015021-pol2qm74 7896 34 survival survival NN cord-015021-pol2qm74 7896 35 time time NN cord-015021-pol2qm74 7896 36 ( ( -LRB- cord-015021-pol2qm74 7896 37 X2 x2 NN cord-015021-pol2qm74 7896 38 = = SYM cord-015021-pol2qm74 7896 39 7.6 7.6 CD cord-015021-pol2qm74 7896 40 , , , cord-015021-pol2qm74 7896 41 p p NN cord-015021-pol2qm74 7896 42 [ [ -LRB- cord-015021-pol2qm74 7896 43 ] ] -RRB- cord-015021-pol2qm74 7896 44 0.02 0.02 CD cord-015021-pol2qm74 7896 45 , , , cord-015021-pol2qm74 7896 46 log.normal log.normal NNP cord-015021-pol2qm74 7896 47 ) ) -RRB- cord-015021-pol2qm74 7896 48 for for IN cord-015021-pol2qm74 7896 49 all all DT cord-015021-pol2qm74 7896 50 893 893 CD cord-015021-pol2qm74 7896 51 patients patient NNS cord-015021-pol2qm74 7896 52 in in IN cord-015021-pol2qm74 7896 53 the the DT cord-015021-pol2qm74 7896 54 trial• trial• NNP cord-015021-pol2qm74 7896 55 Survival Survival NNP cord-015021-pol2qm74 7896 56 benefit benefit NN cord-015021-pol2qm74 7896 57 began begin VBD cord-015021-pol2qm74 7896 58 st st NNP cord-015021-pol2qm74 7896 59 approximately approximately RB cord-015021-pol2qm74 7896 60 24 24 CD cord-015021-pol2qm74 7896 61 % % NN cord-015021-pol2qm74 7896 62 baseline baseline JJ cord-015021-pol2qm74 7896 63 risk risk NN cord-015021-pol2qm74 7896 64 of of IN cord-015021-pol2qm74 7896 65 28-day 28-day CD cord-015021-pol2qm74 7896 66 mortality mortality NN cord-015021-pol2qm74 7896 67 . . . cord-015021-pol2qm74 7897 1 For for IN cord-015021-pol2qm74 7897 2 the the DT cord-015021-pol2qm74 7897 3 $ $ $ cord-015021-pol2qm74 7897 4 80 80 CD cord-015021-pol2qm74 7897 5 patients patient NNS cord-015021-pol2qm74 7897 6 with with IN cord-015021-pol2qm74 7897 7 a a DT cord-015021-pol2qm74 7897 8 predicted predict VBN cord-015021-pol2qm74 7897 9 risk risk NN cord-015021-pol2qm74 7897 10 > > XX cord-015021-pol2qm74 7897 11 24 24 CD cord-015021-pol2qm74 7897 12 % % NN cord-015021-pol2qm74 7897 13 , , , cord-015021-pol2qm74 7897 14 there there EX cord-015021-pol2qm74 7897 15 was be VBD cord-015021-pol2qm74 7897 16 a a DT cord-015021-pol2qm74 7897 17 22 22 CD cord-015021-pol2qm74 7897 18 % % NN cord-015021-pol2qm74 7897 19 reduction reduction NN cord-015021-pol2qm74 7897 20 ( ( -LRB- cord-015021-pol2qm74 7897 21 P=0,00 P=0,00 NNP cord-015021-pol2qm74 7897 22 $ $ $ cord-015021-pol2qm74 7897 23 log log NN cord-015021-pol2qm74 7897 24 normal normal JJ cord-015021-pol2qm74 7897 25 ) ) -RRB- cord-015021-pol2qm74 7897 26 . . . cord-015021-pol2qm74 7898 1 When when WRB cord-015021-pol2qm74 7898 2 we -PRON- PRP cord-015021-pol2qm74 7898 3 examined examine VBD cord-015021-pol2qm74 7898 4 the the DT cord-015021-pol2qm74 7898 5 variation variation NN cord-015021-pol2qm74 7898 6 in in IN cord-015021-pol2qm74 7898 7 patients patient NNS cord-015021-pol2qm74 7898 8 above above IN cord-015021-pol2qm74 7898 9 and and CC cord-015021-pol2qm74 7898 10 below below IN cord-015021-pol2qm74 7898 11 the the DT cord-015021-pol2qm74 7898 12 24 24 CD cord-015021-pol2qm74 7898 13 % % NN cord-015021-pol2qm74 7898 14 risk risk NN cord-015021-pol2qm74 7898 15 level level NN cord-015021-pol2qm74 7898 16 with with IN cord-015021-pol2qm74 7898 17 hazard hazard NN cord-015021-pol2qm74 7898 18 functions function NNS cord-015021-pol2qm74 7898 19 , , , cord-015021-pol2qm74 7898 20 i.e. i.e. FW cord-015021-pol2qm74 7898 21 , , , cord-015021-pol2qm74 7898 22 their -PRON- PRP$ cord-015021-pol2qm74 7898 23 daily daily JJ cord-015021-pol2qm74 7898 24 risk risk NN cord-015021-pol2qm74 7898 25 of of IN cord-015021-pol2qm74 7898 26 death death NN cord-015021-pol2qm74 7898 27 during during IN cord-015021-pol2qm74 7898 28 the the DT cord-015021-pol2qm74 7898 29 study study NN cord-015021-pol2qm74 7898 30 period period NN cord-015021-pol2qm74 7898 31 , , , cord-015021-pol2qm74 7898 32 we -PRON- PRP cord-015021-pol2qm74 7898 33 found find VBD cord-015021-pol2qm74 7898 34 that that IN cord-015021-pol2qm74 7898 35 placebo placebo NN cord-015021-pol2qm74 7898 36 patients patient NNS cord-015021-pol2qm74 7898 37 With with IN cord-015021-pol2qm74 7898 38 < < XX cord-015021-pol2qm74 7898 39 24 24 CD cord-015021-pol2qm74 7898 40 % % NN cord-015021-pol2qm74 7898 41 risk risk NN cord-015021-pol2qm74 7898 42 had have VBD cord-015021-pol2qm74 7898 43 lltile lltile NNP cord-015021-pol2qm74 7898 44 acute acute JJ cord-015021-pol2qm74 7898 45 daffy daffy JJ cord-015021-pol2qm74 7898 46 risk risk NN cord-015021-pol2qm74 7898 47 during during IN cord-015021-pol2qm74 7898 48 the the DT cord-015021-pol2qm74 7898 49 hlltial hlltial JJ cord-015021-pol2qm74 7898 50 two two CD cord-015021-pol2qm74 7898 51 days day NNS cord-015021-pol2qm74 7898 52 follawh follawh JJ cord-015021-pol2qm74 7899 1 ~g ~g NNP cord-015021-pol2qm74 7899 2 study study NN cord-015021-pol2qm74 7899 3 entry entry NN cord-015021-pol2qm74 7899 4 and and CC cord-015021-pol2qm74 7899 5 this this DT cord-015021-pol2qm74 7899 6 risk risk NN cord-015021-pol2qm74 7899 7 was be VBD cord-015021-pol2qm74 7899 8 little little RB cord-015021-pol2qm74 7899 9 affected affect VBN cord-015021-pol2qm74 7899 10 by by IN cord-015021-pol2qm74 7899 11 rhIL rhIL NNP cord-015021-pol2qm74 7899 12 - - HYPH cord-015021-pol2qm74 7899 13 lra lra NNP cord-015021-pol2qm74 7899 14 , , , cord-015021-pol2qm74 7899 15 In in IN cord-015021-pol2qm74 7899 16 contrast contrast NN cord-015021-pol2qm74 7899 17 , , , cord-015021-pol2qm74 7899 18 patients patient NNS cord-015021-pol2qm74 7899 19 with with IN cord-015021-pol2qm74 7899 20 > > XX cord-015021-pol2qm74 7899 21 24 24 CD cord-015021-pol2qm74 7899 22 % % NN cord-015021-pol2qm74 7899 23 risk risk NN cord-015021-pol2qm74 7899 24 had have VBD cord-015021-pol2qm74 7899 25 high high JJ cord-015021-pol2qm74 7899 26 daily daily JJ cord-015021-pol2qm74 7899 27 mortality mortality NN cord-015021-pol2qm74 7899 28 risks risk NNS cord-015021-pol2qm74 7899 29 during during IN cord-015021-pol2qm74 7899 30 the the DT cord-015021-pol2qm74 7899 31 tuttlal tuttlal NN cord-015021-pol2qm74 7899 32 two two CD cord-015021-pol2qm74 7899 33 days day NNS cord-015021-pol2qm74 7899 34 that that WDT cord-015021-pol2qm74 7899 35 high high JJ cord-015021-pol2qm74 7899 36 dose dose NN cord-015021-pol2qm74 7899 37 rhtL rhtL NNPS cord-015021-pol2qm74 7899 38 - - HYPH cord-015021-pol2qm74 7899 39 lro lro NNP cord-015021-pol2qm74 7899 40 substantially substantially RB cord-015021-pol2qm74 7899 41 reduced reduce VBN cord-015021-pol2qm74 7899 42 . . . cord-015021-pol2qm74 7900 1 These these DT cord-015021-pol2qm74 7900 2 results result NNS cord-015021-pol2qm74 7900 3 are be VBP cord-015021-pol2qm74 7900 4 compatible compatible JJ cord-015021-pol2qm74 7900 5 with with IN cord-015021-pol2qm74 7900 6 our -PRON- PRP$ cord-015021-pol2qm74 7900 7 current current JJ cord-015021-pol2qm74 7900 8 understanding understanding NN cord-015021-pol2qm74 7900 9 of of IN cord-015021-pol2qm74 7900 10 outcome outcome NN cord-015021-pol2qm74 7900 11 from from IN cord-015021-pol2qm74 7900 12 sepsis sepsis NN cord-015021-pol2qm74 7900 13 and and CC cord-015021-pol2qm74 7900 14 the the DT cord-015021-pol2qm74 7900 15 proposed propose VBN cord-015021-pol2qm74 7900 16 mechanism mechanism NN cord-015021-pol2qm74 7900 17 of of IN cord-015021-pol2qm74 7900 18 action action NN cord-015021-pol2qm74 7900 19 o£ o£ NNP cord-015021-pol2qm74 7900 20 immunotherapy immunotherapy NN cord-015021-pol2qm74 7900 21 , , , cord-015021-pol2qm74 7900 22 The the DT cord-015021-pol2qm74 7900 23 earliest early JJS cord-015021-pol2qm74 7900 24 deaths death NNS cord-015021-pol2qm74 7900 25 from from IN cord-015021-pol2qm74 7900 26 sop sop NNP cord-015021-pol2qm74 7900 27 sis sis NNP cord-015021-pol2qm74 7900 28 are be VBP cord-015021-pol2qm74 7900 29 secondary secondary JJ cord-015021-pol2qm74 7900 30 to to IN cord-015021-pol2qm74 7900 31 an an DT cord-015021-pol2qm74 7900 32 immediate immediate JJ cord-015021-pol2qm74 7900 33 inflammatory inflammatory JJ cord-015021-pol2qm74 7900 34 response response NN cord-015021-pol2qm74 7900 35 followed follow VBN cord-015021-pol2qm74 7900 36 closely closely RB cord-015021-pol2qm74 7900 37 by by IN cord-015021-pol2qm74 7900 38 deaths death NNS cord-015021-pol2qm74 7900 39 secondary secondary JJ cord-015021-pol2qm74 7900 40 to to IN cord-015021-pol2qm74 7900 41 multiple multiple JJ cord-015021-pol2qm74 7900 42 organ organ NN cord-015021-pol2qm74 7900 43 system system NN cord-015021-pol2qm74 7900 44 failure failure NN cord-015021-pol2qm74 7900 45 , , , cord-015021-pol2qm74 7900 46 Later later JJ cord-015021-pol2qm74 7900 47 deaths death NNS cord-015021-pol2qm74 7900 48 ( ( -LRB- cord-015021-pol2qm74 7900 49 after after IN cord-015021-pol2qm74 7900 50 14 14 CD cord-015021-pol2qm74 7900 51 days day NNS cord-015021-pol2qm74 7900 52 ) ) -RRB- cord-015021-pol2qm74 7900 53 are be VBP cord-015021-pol2qm74 7900 54 not not RB cord-015021-pol2qm74 7900 55 as as RB cord-015021-pol2qm74 7900 56 closely closely RB cord-015021-pol2qm74 7900 57 related relate VBN cord-015021-pol2qm74 7900 58 to to IN cord-015021-pol2qm74 7900 59 the the DT cord-015021-pol2qm74 7900 60 acute acute JJ cord-015021-pol2qm74 7900 61 effeete effeete NN cord-015021-pol2qm74 7900 62 of of IN cord-015021-pol2qm74 7900 63 the the DT cord-015021-pol2qm74 7900 64 inflammatory inflammatory JJ cord-015021-pol2qm74 7900 65 cascade cascade NN cord-015021-pol2qm74 7900 66 . . . cord-015021-pol2qm74 7901 1 Because because IN cord-015021-pol2qm74 7901 2 of of IN cord-015021-pol2qm74 7901 3 the the DT cord-015021-pol2qm74 7901 4 timing timing NN cord-015021-pol2qm74 7901 5 and and CC cord-015021-pol2qm74 7901 6 action action NN cord-015021-pol2qm74 7901 7 of of IN cord-015021-pol2qm74 7901 8 most most RBS cord-015021-pol2qm74 7901 9 proposed propose VBN cord-015021-pol2qm74 7901 10 tmmunotherapy tmmunotherapy NNP cord-015021-pol2qm74 7901 11 , , , cord-015021-pol2qm74 7901 12 they -PRON- PRP cord-015021-pol2qm74 7901 13 may may MD cord-015021-pol2qm74 7901 14 be be VB cord-015021-pol2qm74 7901 15 capable capable JJ cord-015021-pol2qm74 7901 16 of of IN cord-015021-pol2qm74 7901 17 preventing prevent VBG cord-015021-pol2qm74 7901 18 mortality mortality NN cord-015021-pol2qm74 7901 19 primarily primarily RB cord-015021-pol2qm74 7901 20 in in IN cord-015021-pol2qm74 7901 21 these these DT cord-015021-pol2qm74 7901 22 initial initial JJ cord-015021-pol2qm74 7901 23 two two CD cord-015021-pol2qm74 7901 24 phases phase NNS cord-015021-pol2qm74 7901 25 . . . cord-015021-pol2qm74 7902 1 In in IN cord-015021-pol2qm74 7902 2 this this DT cord-015021-pol2qm74 7902 3 study study NN cord-015021-pol2qm74 7902 4 , , , cord-015021-pol2qm74 7902 5 an an DT cord-015021-pol2qm74 7902 6 independent independent JJ cord-015021-pol2qm74 7902 7 predicted predict VBD cord-015021-pol2qm74 7902 8 risk risk NN cord-015021-pol2qm74 7902 9 of of IN cord-015021-pol2qm74 7902 10 mortality mortality NN cord-015021-pol2qm74 7902 11 reflected reflect VBD cord-015021-pol2qm74 7902 12 this this DT cord-015021-pol2qm74 7902 13 mortality mortality NN cord-015021-pol2qm74 7902 14 pattern pattern NN cord-015021-pol2qm74 7902 15 ned ned NNP cord-015021-pol2qm74 7902 16 illustrated illustrate VBD cord-015021-pol2qm74 7902 17 the the DT cord-015021-pol2qm74 7902 18 potential potential JJ cord-015021-pol2qm74 7902 19 benefit benefit NN cord-015021-pol2qm74 7902 20 of of IN cord-015021-pol2qm74 7902 21 immtmotherapy immtmotherapy NNP cord-015021-pol2qm74 7902 22 . . . cord-015021-pol2qm74 7903 1 Use use NN cord-015021-pol2qm74 7903 2 of of IN cord-015021-pol2qm74 7903 3 a a DT cord-015021-pol2qm74 7903 4 predicted predict VBN cord-015021-pol2qm74 7903 5 risk risk NN cord-015021-pol2qm74 7903 6 of of IN cord-015021-pol2qm74 7903 7 mortality mortality NN cord-015021-pol2qm74 7903 8 in in IN cord-015021-pol2qm74 7903 9 the the DT cord-015021-pol2qm74 7903 10 design design NN cord-015021-pol2qm74 7903 11 and and CC cord-015021-pol2qm74 7903 12 analysis analysis NN cord-015021-pol2qm74 7903 13 of of IN cord-015021-pol2qm74 7903 14 clinical clinical JJ cord-015021-pol2qm74 7903 15 trials trial NNS cord-015021-pol2qm74 7903 16 could could MD cord-015021-pol2qm74 7903 17 improve improve VB cord-015021-pol2qm74 7903 18 our -PRON- PRP$ cord-015021-pol2qm74 7903 19 understanding understanding NN cord-015021-pol2qm74 7903 20 of of IN cord-015021-pol2qm74 7903 21 the the DT cord-015021-pol2qm74 7903 22 clinical clinical JJ cord-015021-pol2qm74 7903 23 benefit benefit NN cord-015021-pol2qm74 7903 24 of of IN cord-015021-pol2qm74 7903 25 these these DT cord-015021-pol2qm74 7903 26 new new JJ cord-015021-pol2qm74 7903 27 therapeutic therapeutic JJ cord-015021-pol2qm74 7903 28 approaches approach NNS cord-015021-pol2qm74 7903 29 . . . cord-015021-pol2qm74 7904 1 The the DT cord-015021-pol2qm74 7904 2 systemic systemic JJ cord-015021-pol2qm74 7904 3 inflammatory inflammatory JJ cord-015021-pol2qm74 7904 4 response response NN cord-015021-pol2qm74 7904 5 syndrome syndrome NN cord-015021-pol2qm74 7904 6 ( ( -LRB- cord-015021-pol2qm74 7904 7 SIRS SIRS NNP cord-015021-pol2qm74 7904 8 ) ) -RRB- cord-015021-pol2qm74 7904 9 is be VBZ cord-015021-pol2qm74 7904 10 a a DT cord-015021-pol2qm74 7904 11 term term NN cord-015021-pol2qm74 7904 12 recently recently RB cord-015021-pol2qm74 7904 13 proposed propose VBN cord-015021-pol2qm74 7904 14 to to TO cord-015021-pol2qm74 7904 15 describe describe VB cord-015021-pol2qm74 7904 16 patients patient NNS cord-015021-pol2qm74 7904 17 with with IN cord-015021-pol2qm74 7904 18 systemic systemic JJ cord-015021-pol2qm74 7904 19 inflammatory inflammatory JJ cord-015021-pol2qm74 7904 20 responses response NNS cord-015021-pol2qm74 7904 21 to to IN cord-015021-pol2qm74 7904 22 insults insult NNS cord-015021-pol2qm74 7904 23 such such JJ cord-015021-pol2qm74 7904 24 as as IN cord-015021-pol2qm74 7904 25 infections infection NNS cord-015021-pol2qm74 7904 26 ( ( -LRB- cord-015021-pol2qm74 7904 27 sepsis sepsis NN cord-015021-pol2qm74 7904 28 ) ) -RRB- cord-015021-pol2qm74 7904 29 , , , cord-015021-pol2qm74 7904 30 trauma trauma NN cord-015021-pol2qm74 7904 31 , , , cord-015021-pol2qm74 7904 32 burns burn NNS cord-015021-pol2qm74 7904 33 , , , cord-015021-pol2qm74 7904 34 pancreatitis pancreatitis NN cord-015021-pol2qm74 7904 35 , , , cord-015021-pol2qm74 7904 36 and and CC cord-015021-pol2qm74 7904 37 other other JJ cord-015021-pol2qm74 7904 38 initiating initiate VBG cord-015021-pol2qm74 7904 39 events event NNS cord-015021-pol2qm74 7904 40 . . . cord-015021-pol2qm74 7905 1 Patients patient NNS cord-015021-pol2qm74 7905 2 with with IN cord-015021-pol2qm74 7905 3 SIRS SIRS NNP cord-015021-pol2qm74 7905 4 may may MD cord-015021-pol2qm74 7905 5 have have VB cord-015021-pol2qm74 7905 6 similar similar JJ cord-015021-pol2qm74 7905 7 activation activation NN cord-015021-pol2qm74 7905 8 of of IN cord-015021-pol2qm74 7905 9 inflammatory inflammatory JJ cord-015021-pol2qm74 7905 10 mediators mediator NNS cord-015021-pol2qm74 7905 11 and and CC cord-015021-pol2qm74 7905 12 similar similar JJ cord-015021-pol2qm74 7905 13 outcomes outcome NNS cord-015021-pol2qm74 7905 14 independent independent JJ cord-015021-pol2qm74 7905 15 of of IN cord-015021-pol2qm74 7905 16 the the DT cord-015021-pol2qm74 7905 17 initiating initiate VBG cord-015021-pol2qm74 7905 18 event event NN cord-015021-pol2qm74 7905 19 . . . cord-015021-pol2qm74 7906 1 These these DT cord-015021-pol2qm74 7906 2 outcomes outcome NNS cord-015021-pol2qm74 7906 3 include include VBP cord-015021-pol2qm74 7906 4 organ organ NN cord-015021-pol2qm74 7906 5 dysfunction dysfunction NN cord-015021-pol2qm74 7906 6 and and CC cord-015021-pol2qm74 7906 7 failure failure NN cord-015021-pol2qm74 7906 8 , , , cord-015021-pol2qm74 7906 9 shock shock NN cord-015021-pol2qm74 7906 10 , , , cord-015021-pol2qm74 7906 11 and and CC cord-015021-pol2qm74 7906 12 death death NN cord-015021-pol2qm74 7906 13 . . . cord-015021-pol2qm74 7907 1 Challenges challenge NNS cord-015021-pol2qm74 7907 2 to to IN cord-015021-pol2qm74 7907 3 the the DT cord-015021-pol2qm74 7907 4 successful successful JJ cord-015021-pol2qm74 7907 5 conduct conduct NN cord-015021-pol2qm74 7907 6 of of IN cord-015021-pol2qm74 7907 7 clinical clinical JJ cord-015021-pol2qm74 7907 8 trials trial NNS cord-015021-pol2qm74 7907 9 in in IN cord-015021-pol2qm74 7907 10 SIRS sir NNS cord-015021-pol2qm74 7907 11 include include VBP cord-015021-pol2qm74 7907 12 the the DT cord-015021-pol2qm74 7907 13 complexity complexity NN cord-015021-pol2qm74 7907 14 of of IN cord-015021-pol2qm74 7907 15 illness illness NN cord-015021-pol2qm74 7907 16 in in IN cord-015021-pol2qm74 7907 17 these these DT cord-015021-pol2qm74 7907 18 patients patient NNS cord-015021-pol2qm74 7907 19 and and CC cord-015021-pol2qm74 7907 20 the the DT cord-015021-pol2qm74 7907 21 important important JJ cord-015021-pol2qm74 7907 22 -- -- : cord-015021-pol2qm74 7907 23 but but CC cord-015021-pol2qm74 7907 24 limited limited JJ cord-015021-pol2qm74 7907 25 -- -- : cord-015021-pol2qm74 7907 26 clinical clinical JJ cord-015021-pol2qm74 7907 27 benefits benefit NNS cord-015021-pol2qm74 7907 28 of of IN cord-015021-pol2qm74 7907 29 novel novel JJ cord-015021-pol2qm74 7907 30 compounds compound NNS cord-015021-pol2qm74 7907 31 that that WDT cord-015021-pol2qm74 7907 32 may may MD cord-015021-pol2qm74 7907 33 be be VB cord-015021-pol2qm74 7907 34 limited limit VBN cord-015021-pol2qm74 7907 35 to to IN cord-015021-pol2qm74 7907 36 selected select VBN cord-015021-pol2qm74 7907 37 patient patient JJ cord-015021-pol2qm74 7907 38 subsets subset NNS cord-015021-pol2qm74 7907 39 . . . cord-015021-pol2qm74 7908 1 Addressing address VBG cord-015021-pol2qm74 7908 2 these these DT cord-015021-pol2qm74 7908 3 challenges challenge NNS cord-015021-pol2qm74 7908 4 will will MD cord-015021-pol2qm74 7908 5 require require VB cord-015021-pol2qm74 7908 6 new new JJ cord-015021-pol2qm74 7908 7 tools tool NNS cord-015021-pol2qm74 7908 8 and and CC cord-015021-pol2qm74 7908 9 approaches approach NNS cord-015021-pol2qm74 7908 10 . . . cord-015021-pol2qm74 7909 1 These these DT cord-015021-pol2qm74 7909 2 will will MD cord-015021-pol2qm74 7909 3 include include VB cord-015021-pol2qm74 7909 4 more more RBR cord-015021-pol2qm74 7909 5 sensitive sensitive JJ cord-015021-pol2qm74 7909 6 and and CC cord-015021-pol2qm74 7909 7 appropriate appropriate JJ cord-015021-pol2qm74 7909 8 endpoints endpoint NNS cord-015021-pol2qm74 7909 9 , , , cord-015021-pol2qm74 7909 10 and and CC cord-015021-pol2qm74 7909 11 the the DT cord-015021-pol2qm74 7909 12 use use NN cord-015021-pol2qm74 7909 13 of of IN cord-015021-pol2qm74 7909 14 methods method NNS cord-015021-pol2qm74 7909 15 such such JJ cord-015021-pol2qm74 7909 16 as as IN cord-015021-pol2qm74 7909 17 baseline baseline JJ cord-015021-pol2qm74 7909 18 risk risk NN cord-015021-pol2qm74 7909 19 adjustment adjustment NN cord-015021-pol2qm74 7909 20 , , , cord-015021-pol2qm74 7909 21 to to TO cord-015021-pol2qm74 7909 22 allow allow VB cord-015021-pol2qm74 7909 23 detection detection NN cord-015021-pol2qm74 7909 24 of of IN cord-015021-pol2qm74 7909 25 drug drug NN cord-015021-pol2qm74 7909 26 risk risk NN cord-015021-pol2qm74 7909 27 interactions interaction NNS cord-015021-pol2qm74 7909 28 not not RB cord-015021-pol2qm74 7909 29 captured capture VBN cord-015021-pol2qm74 7909 30 adequately adequately RB cord-015021-pol2qm74 7909 31 by by IN cord-015021-pol2qm74 7909 32 categorical categorical JJ cord-015021-pol2qm74 7909 33 definitions definition NNS cord-015021-pol2qm74 7909 34 , , , cord-015021-pol2qm74 7909 35 such such JJ cord-015021-pol2qm74 7909 36 as as IN cord-015021-pol2qm74 7909 37 sepsis sepsis NN cord-015021-pol2qm74 7909 38 syndrome syndrome NN cord-015021-pol2qm74 7909 39 . . . cord-015021-pol2qm74 7910 1 On on IN cord-015021-pol2qm74 7910 2 the the DT cord-015021-pol2qm74 7910 3 basis basis NN cord-015021-pol2qm74 7910 4 of of IN cord-015021-pol2qm74 7910 5 supportive supportive JJ cord-015021-pol2qm74 7910 6 preclinical preclinical JJ cord-015021-pol2qm74 7910 7 and and CC cord-015021-pol2qm74 7910 8 Phase phase NN cord-015021-pol2qm74 7910 9 I -PRON- PRP cord-015021-pol2qm74 7910 10 safety safety NN cord-015021-pol2qm74 7910 11 studies study NNS cord-015021-pol2qm74 7910 12 , , , cord-015021-pol2qm74 7910 13 we -PRON- PRP cord-015021-pol2qm74 7910 14 have have VBP cord-015021-pol2qm74 7910 15 initiated initiate VBN cord-015021-pol2qm74 7910 16 Phase Phase NNP cord-015021-pol2qm74 7910 17 II II NNP cord-015021-pol2qm74 7910 18 clinical clinical JJ cord-015021-pol2qm74 7910 19 trials trial NNS cord-015021-pol2qm74 7910 20 of of IN cord-015021-pol2qm74 7910 21 a a DT cord-015021-pol2qm74 7910 22 novel novel JJ cord-015021-pol2qm74 7910 23 bradykinin bradykinin NN cord-015021-pol2qm74 7910 24 antagonist antagonist NN cord-015021-pol2qm74 7910 25 , , , cord-015021-pol2qm74 7910 26 CP-0127 CP-0127 NNP cord-015021-pol2qm74 7910 27 , , , cord-015021-pol2qm74 7910 28 in in IN cord-015021-pol2qm74 7910 29 four four CD cord-015021-pol2qm74 7910 30 SIRS SIRS NNP cord-015021-pol2qm74 7910 31 subcategofies subcategofie NNS cord-015021-pol2qm74 7910 32 : : : cord-015021-pol2qm74 7910 33 sepsis sepsis NN cord-015021-pol2qm74 7910 34 , , , cord-015021-pol2qm74 7910 35 multiple multiple JJ cord-015021-pol2qm74 7910 36 trauma trauma NN cord-015021-pol2qm74 7910 37 , , , cord-015021-pol2qm74 7910 38 burns burn NNS cord-015021-pol2qm74 7910 39 , , , cord-015021-pol2qm74 7910 40 and and CC cord-015021-pol2qm74 7910 41 pancreatitis pancreatitis NN cord-015021-pol2qm74 7910 42 . . . cord-015021-pol2qm74 7911 1 Each each DT cord-015021-pol2qm74 7911 2 of of IN cord-015021-pol2qm74 7911 3 these these DT cord-015021-pol2qm74 7911 4 studies study NNS cord-015021-pol2qm74 7911 5 is be VBZ cord-015021-pol2qm74 7911 6 designed design VBN cord-015021-pol2qm74 7911 7 to to TO cord-015021-pol2qm74 7911 8 measure measure VB cord-015021-pol2qm74 7911 9 the the DT cord-015021-pol2qm74 7911 10 effect effect NN cord-015021-pol2qm74 7911 11 of of IN cord-015021-pol2qm74 7911 12 CP-0127 cp-0127 NN cord-015021-pol2qm74 7911 13 on on IN cord-015021-pol2qm74 7911 14 mortality mortality NN cord-015021-pol2qm74 7911 15 , , , cord-015021-pol2qm74 7911 16 organ organ NN cord-015021-pol2qm74 7911 17 dysfunction dysfunction NN cord-015021-pol2qm74 7911 18 and and CC cord-015021-pol2qm74 7911 19 failure failure NN cord-015021-pol2qm74 7911 20 , , , cord-015021-pol2qm74 7911 21 and and CC cord-015021-pol2qm74 7911 22 activation activation NN cord-015021-pol2qm74 7911 23 of of IN cord-015021-pol2qm74 7911 24 mediators mediator NNS cord-015021-pol2qm74 7911 25 . . . cord-015021-pol2qm74 7912 1 In in IN cord-015021-pol2qm74 7912 2 addition addition NN cord-015021-pol2qm74 7912 3 to to IN cord-015021-pol2qm74 7912 4 investigating investigate VBG cord-015021-pol2qm74 7912 5 rates rate NNS cord-015021-pol2qm74 7912 6 of of IN cord-015021-pol2qm74 7912 7 organ organ NN cord-015021-pol2qm74 7912 8 failure failure NN cord-015021-pol2qm74 7912 9 using use VBG cord-015021-pol2qm74 7912 10 standard standard JJ cord-015021-pol2qm74 7912 11 definitions definition NNS cord-015021-pol2qm74 7912 12 -- -- : cord-015021-pol2qm74 7912 13 a a DT cord-015021-pol2qm74 7912 14 new new JJ cord-015021-pol2qm74 7912 15 endpoint endpoint NN cord-015021-pol2qm74 7912 16 -- -- : cord-015021-pol2qm74 7912 17 a a DT cord-015021-pol2qm74 7912 18 continuous continuous JJ cord-015021-pol2qm74 7912 19 summary summary NN cord-015021-pol2qm74 7912 20 measure measure NN cord-015021-pol2qm74 7912 21 of of IN cord-015021-pol2qm74 7912 22 organ organ NN cord-015021-pol2qm74 7912 23 dysfunction dysfunction NN cord-015021-pol2qm74 7912 24 ( ( -LRB- cord-015021-pol2qm74 7912 25 the the DT cord-015021-pol2qm74 7912 26 Acute Acute NNP cord-015021-pol2qm74 7912 27 Physiology Physiology NNP cord-015021-pol2qm74 7912 28 Score Score NNP cord-015021-pol2qm74 7912 29 of of IN cord-015021-pol2qm74 7912 30 APACHE APACHE NNP cord-015021-pol2qm74 7912 31 TM TM NNP cord-015021-pol2qm74 7912 32 III III NNP cord-015021-pol2qm74 7912 33 ) ) -RRB- cord-015021-pol2qm74 7912 34 is be VBZ cord-015021-pol2qm74 7912 35 being be VBG cord-015021-pol2qm74 7912 36 used use VBN cord-015021-pol2qm74 7912 37 to to TO cord-015021-pol2qm74 7912 38 quantify quantify VB cord-015021-pol2qm74 7912 39 the the DT cord-015021-pol2qm74 7912 40 degree degree NN cord-015021-pol2qm74 7912 41 of of IN cord-015021-pol2qm74 7912 42 organ organ NN cord-015021-pol2qm74 7912 43 dysfunction dysfunction NN cord-015021-pol2qm74 7912 44 and and CC cord-015021-pol2qm74 7912 45 the the DT cord-015021-pol2qm74 7912 46 speed speed NN cord-015021-pol2qm74 7912 47 and and CC cord-015021-pol2qm74 7912 48 pattern pattern NN cord-015021-pol2qm74 7912 49 of of IN cord-015021-pol2qm74 7912 50 recovery recovery NN cord-015021-pol2qm74 7912 51 of of IN cord-015021-pol2qm74 7912 52 physiologic physiologic JJ cord-015021-pol2qm74 7912 53 stability stability NN cord-015021-pol2qm74 7912 54 . . . cord-015021-pol2qm74 7913 1 In in IN cord-015021-pol2qm74 7913 2 the the DT cord-015021-pol2qm74 7913 3 sepsis sepsis NN cord-015021-pol2qm74 7913 4 study study NN cord-015021-pol2qm74 7913 5 , , , cord-015021-pol2qm74 7913 6 another another DT cord-015021-pol2qm74 7913 7 new new JJ cord-015021-pol2qm74 7913 8 approach approach NN cord-015021-pol2qm74 7913 9 -- -- : cord-015021-pol2qm74 7913 10 a a DT cord-015021-pol2qm74 7913 11 study study NN cord-015021-pol2qm74 7913 12 specific specific JJ cord-015021-pol2qm74 7913 13 risk risk NN cord-015021-pol2qm74 7913 14 model model NN cord-015021-pol2qm74 7913 15 based base VBN cord-015021-pol2qm74 7913 16 on on IN cord-015021-pol2qm74 7913 17 the the DT cord-015021-pol2qm74 7913 18 APACHE APACHE NNP cord-015021-pol2qm74 7913 19 Ill Ill NNP cord-015021-pol2qm74 7913 20 database database NN cord-015021-pol2qm74 7913 21 -- -- : cord-015021-pol2qm74 7913 22 has have VBZ cord-015021-pol2qm74 7913 23 been be VBN cord-015021-pol2qm74 7913 24 developed develop VBN cord-015021-pol2qm74 7913 25 which which WDT cord-015021-pol2qm74 7913 26 will will MD cord-015021-pol2qm74 7913 27 be be VB cord-015021-pol2qm74 7913 28 used use VBN cord-015021-pol2qm74 7913 29 to to TO cord-015021-pol2qm74 7913 30 assign assign VB cord-015021-pol2qm74 7913 31 a a DT cord-015021-pol2qm74 7913 32 pre pre JJ cord-015021-pol2qm74 7913 33 - - JJ cord-015021-pol2qm74 7913 34 treatment treatment JJ cord-015021-pol2qm74 7913 35 baseline baseline JJ cord-015021-pol2qm74 7913 36 risk risk NN cord-015021-pol2qm74 7913 37 to to IN cord-015021-pol2qm74 7913 38 each each DT cord-015021-pol2qm74 7913 39 patient patient NN cord-015021-pol2qm74 7913 40 enrolled enrol VBN cord-015021-pol2qm74 7913 41 . . . cord-015021-pol2qm74 7914 1 The the DT cord-015021-pol2qm74 7914 2 primary primary JJ cord-015021-pol2qm74 7914 3 outcome outcome NN cord-015021-pol2qm74 7914 4 variable variable NN cord-015021-pol2qm74 7914 5 will will MD cord-015021-pol2qm74 7914 6 be be VB cord-015021-pol2qm74 7914 7 risk risk NN cord-015021-pol2qm74 7914 8 adjusted adjust VBN cord-015021-pol2qm74 7914 9 survival survival NN cord-015021-pol2qm74 7914 10 time time NN cord-015021-pol2qm74 7914 11 to to IN cord-015021-pol2qm74 7914 12 28 28 CD cord-015021-pol2qm74 7914 13 days day NNS cord-015021-pol2qm74 7914 14 . . . cord-015021-pol2qm74 7915 1 This this DT cord-015021-pol2qm74 7915 2 type type NN cord-015021-pol2qm74 7915 3 of of IN cord-015021-pol2qm74 7915 4 risk risk NN cord-015021-pol2qm74 7915 5 - - HYPH cord-015021-pol2qm74 7915 6 adjusted adjust VBN cord-015021-pol2qm74 7915 7 analysis analysis NN cord-015021-pol2qm74 7915 8 may may MD cord-015021-pol2qm74 7915 9 allow allow VB cord-015021-pol2qm74 7915 10 for for IN cord-015021-pol2qm74 7915 11 more more RBR cord-015021-pol2qm74 7915 12 efficient efficient JJ cord-015021-pol2qm74 7915 13 and and CC cord-015021-pol2qm74 7915 14 powerful powerful JJ cord-015021-pol2qm74 7915 15 trials trial NNS cord-015021-pol2qm74 7915 16 and and CC cord-015021-pol2qm74 7915 17 more more RBR cord-015021-pol2qm74 7915 18 accurate accurate JJ cord-015021-pol2qm74 7915 19 and and CC cord-015021-pol2qm74 7915 20 useful useful JJ cord-015021-pol2qm74 7915 21 indications indication NNS cord-015021-pol2qm74 7915 22 for for IN cord-015021-pol2qm74 7915 23 use use NN cord-015021-pol2qm74 7915 24 . . . cord-015021-pol2qm74 7916 1 Study study NN cord-015021-pol2qm74 7916 2 PurPose PurPose NNP cord-015021-pol2qm74 7916 3 : : : cord-015021-pol2qm74 7917 1 In in IN cord-015021-pol2qm74 7917 2 post post JJ cord-015021-pol2qm74 7917 3 - - JJ cord-015021-pol2qm74 7917 4 cardiac cardiac JJ cord-015021-pol2qm74 7917 5 surgical surgical JJ cord-015021-pol2qm74 7917 6 patients patient NNS cord-015021-pol2qm74 7917 7 ( ( -LRB- cord-015021-pol2qm74 7917 8 pat pat NNP cord-015021-pol2qm74 7917 9 . . . cord-015021-pol2qm74 7917 10 ) ) -RRB- cord-015021-pol2qm74 7917 11 at at IN cord-015021-pol2qm74 7917 12 risk risk NN cord-015021-pol2qm74 7917 13 for for IN cord-015021-pol2qm74 7917 14 sepsis sepsis NN cord-015021-pol2qm74 7917 15 , , , cord-015021-pol2qm74 7917 16 the the DT cord-015021-pol2qm74 7917 17 efficacy efficacy NN cord-015021-pol2qm74 7917 18 of of IN cord-015021-pol2qm74 7917 19 early early JJ cord-015021-pol2qm74 7917 20 i.v i.v NNP cord-015021-pol2qm74 7917 21 . . . cord-015021-pol2qm74 7917 22 immunoglobulin immunoglobulin NN cord-015021-pol2qm74 7917 23 ( ( -LRB- cord-015021-pol2qm74 7917 24 Ig Ig NNP cord-015021-pol2qm74 7917 25 ) ) -RRB- cord-015021-pol2qm74 7917 26 treatment treatment NN cord-015021-pol2qm74 7917 27 was be VBD cord-015021-pol2qm74 7917 28 compared compare VBN cord-015021-pol2qm74 7917 29 to to IN cord-015021-pol2qm74 7917 30 a a DT cord-015021-pol2qm74 7917 31 matching match VBG cord-015021-pol2qm74 7917 32 historical historical JJ cord-015021-pol2qm74 7917 33 control control NN cord-015021-pol2qm74 7917 34 ( ( -LRB- cord-015021-pol2qm74 7917 35 con con NN cord-015021-pol2qm74 7917 36 . . . cord-015021-pol2qm74 7917 37 ) ) -RRB- cord-015021-pol2qm74 7917 38 population population NN cord-015021-pol2qm74 7917 39 . . . cord-015021-pol2qm74 7918 1 Postoperative postoperative JJ cord-015021-pol2qm74 7918 2 risk risk NN cord-015021-pol2qm74 7918 3 assessment assessment NN cord-015021-pol2qm74 7918 4 : : : cord-015021-pol2qm74 7919 1 Using use VBG cord-015021-pol2qm74 7919 2 APACHE APACHE NNP cord-015021-pol2qm74 7919 3 II II NNP cord-015021-pol2qm74 7919 4 scores score NNS cord-015021-pol2qm74 7919 5 LAP LAP NNP cord-015021-pol2qm74 7919 6 ) ) -RRB- cord-015021-pol2qm74 7919 7 ( ( -LRB- cord-015021-pol2qm74 7919 8 first first JJ cord-015021-pol2qm74 7919 9 postoperative postoperative JJ cord-015021-pol2qm74 7919 10 [ [ -LRB- cord-015021-pol2qm74 7919 11 pop pop NN cord-015021-pol2qm74 7919 12 . . . cord-015021-pol2qm74 7919 13 ] ] -RRB- cord-015021-pol2qm74 7920 1 day day NN cord-015021-pol2qm74 7920 2 ) ) -RRB- cord-015021-pol2qm74 7920 3 in in IN cord-015021-pol2qm74 7920 4 a a DT cord-015021-pol2qm74 7920 5 pilot pilot NN cord-015021-pol2qm74 7920 6 study study NN cord-015021-pol2qm74 7920 7 phase phase NN cord-015021-pol2qm74 7920 8 , , , cord-015021-pol2qm74 7920 9 we -PRON- PRP cord-015021-pol2qm74 7920 10 were be VBD cord-015021-pol2qm74 7920 11 able able JJ cord-015021-pol2qm74 7920 12 to to TO cord-015021-pol2qm74 7920 13 differentiate differentiate VB cord-015021-pol2qm74 7920 14 between between IN cord-015021-pol2qm74 7920 15 the the DT cord-015021-pol2qm74 7920 16 large large JJ cord-015021-pol2qm74 7920 17 population population NN cord-015021-pol2qm74 7920 18 ( ( -LRB- cord-015021-pol2qm74 7920 19 95.2 95.2 CD cord-015021-pol2qm74 7920 20 % % NN cord-015021-pol2qm74 7920 21 ) ) -RRB- cord-015021-pol2qm74 7920 22 of of IN cord-015021-pol2qm74 7920 23 pop pop NN cord-015021-pol2qm74 7920 24 . . . cord-015021-pol2qm74 7921 1 low low JJ cord-015021-pol2qm74 7921 2 - - HYPH cord-015021-pol2qm74 7921 3 risk risk NN cord-015021-pol2qm74 7921 4 pat pat NN cord-015021-pol2qm74 7921 5 . . . cord-015021-pol2qm74 7922 1 ( ( -LRB- cord-015021-pol2qm74 7922 2 AP AP NNP cord-015021-pol2qm74 7922 3 < < XX cord-015021-pol2qm74 7922 4 19 19 CD cord-015021-pol2qm74 7922 5 ; ; : cord-015021-pol2qm74 7922 6 mortality mortality NN cord-015021-pol2qm74 7922 7 : : : cord-015021-pol2qm74 7922 8 1 1 CD cord-015021-pol2qm74 7922 9 % % NN cord-015021-pol2qm74 7922 10 ) ) -RRB- cord-015021-pol2qm74 7922 11 and and CC cord-015021-pol2qm74 7922 12 the the DT cord-015021-pol2qm74 7922 13 small small JJ cord-015021-pol2qm74 7922 14 groups group NNS cord-015021-pol2qm74 7922 15 of of IN cord-015021-pol2qm74 7922 16 pop pop NN cord-015021-pol2qm74 7922 17 . . . cord-015021-pol2qm74 7923 1 pat pat NNP cord-015021-pol2qm74 7923 2 . . . cord-015021-pol2qm74 7924 1 at at IN cord-015021-pol2qm74 7924 2 risk risk NN cord-015021-pol2qm74 7925 1 LAP= lap= CD cord-015021-pol2qm74 7925 2 19 19 CD cord-015021-pol2qm74 7925 3 - - SYM cord-015021-pol2qm74 7925 4 23 23 CD cord-015021-pol2qm74 7925 5 ) ) -RRB- cord-015021-pol2qm74 7925 6 and and CC cord-015021-pol2qm74 7925 7 high high JJ cord-015021-pol2qm74 7925 8 risk risk NN cord-015021-pol2qm74 7925 9 LAP_24 LAP_24 NNP cord-015021-pol2qm74 7925 10 ) ) -RRB- cord-015021-pol2qm74 7925 11 with with IN cord-015021-pol2qm74 7925 12 a a DT cord-015021-pol2qm74 7925 13 significantly significantly RB cord-015021-pol2qm74 7925 14 higher high JJR cord-015021-pol2qm74 7925 15 mortality mortality NN cord-015021-pol2qm74 7925 16 ( ( -LRB- cord-015021-pol2qm74 7925 17 14 14 CD cord-015021-pol2qm74 7925 18 % % NN cord-015021-pol2qm74 7925 19 and and CC cord-015021-pol2qm74 7925 20 76 76 CD cord-015021-pol2qm74 7925 21 % % NN cord-015021-pol2qm74 7925 22 , , , cord-015021-pol2qm74 7925 23 mainly mainly RB cord-015021-pol2qm74 7925 24 due due IN cord-015021-pol2qm74 7925 25 to to IN cord-015021-pol2qm74 7925 26 sepsis sepsis NN cord-015021-pol2qm74 7925 27 ) ) -RRB- cord-015021-pol2qm74 7925 28 . . . cord-015021-pol2qm74 7926 1 Subsequently subsequently RB cord-015021-pol2qm74 7926 2 , , , cord-015021-pol2qm74 7926 3 among among IN cord-015021-pol2qm74 7926 4 1341 1341 CD cord-015021-pol2qm74 7926 5 consecutive consecutive JJ cord-015021-pol2qm74 7926 6 pop pop NN cord-015021-pol2qm74 7926 7 . . . cord-015021-pol2qm74 7927 1 pat pat NNP cord-015021-pol2qm74 7927 2 . . . cord-015021-pol2qm74 7928 1 we -PRON- PRP cord-015021-pol2qm74 7928 2 prospectively prospectively RB cord-015021-pol2qm74 7928 3 identified identify VBD cord-015021-pol2qm74 7928 4 and and CC cord-015021-pol2qm74 7928 5 treated treat VBD cord-015021-pol2qm74 7928 6 these these DT cord-015021-pol2qm74 7928 7 pat pat NN cord-015021-pol2qm74 7928 8 . . . cord-015021-pol2qm74 7929 1 Iq Iq NNP cord-015021-pol2qm74 7929 2 treatment treatment NN cord-015021-pol2qm74 7929 3 reqimens reqimens NNP cord-015021-pol2qm74 7929 4 : : : cord-015021-pol2qm74 7930 1 First first JJ cord-015021-pol2qm74 7930 2 study study NN cord-015021-pol2qm74 7930 3 period period NN cord-015021-pol2qm74 7930 4 ( ( -LRB- cord-015021-pol2qm74 7930 5 n n NN cord-015021-pol2qm74 7930 6 = = SYM cord-015021-pol2qm74 7930 7 41 41 CD cord-015021-pol2qm74 7930 8 ) ) -RRB- cord-015021-pol2qm74 7930 9 : : : cord-015021-pol2qm74 7931 1 ( ( -LRB- cord-015021-pol2qm74 7931 2 gG gG NNP cord-015021-pol2qm74 7932 1 ( ( -LRB- cord-015021-pol2qm74 7932 2 Psomaglobin Psomaglobin NNP cord-015021-pol2qm74 7932 3 N N NNP cord-015021-pol2qm74 7932 4 a a NNP cord-015021-pol2qm74 7932 5 , , , cord-015021-pol2qm74 7932 6 Tropon Tropon NNP cord-015021-pol2qm74 7932 7 Biologische Biologische NNP cord-015021-pol2qm74 7932 8 Pr Pr NNP cord-015021-pol2qm74 7932 9 ~ ~ NNP cord-015021-pol2qm74 7932 10 parate parate NN cord-015021-pol2qm74 7932 11 , , , cord-015021-pol2qm74 7932 12 Cologne Cologne NNP cord-015021-pol2qm74 7932 13 , , , cord-015021-pol2qm74 7932 14 FRG FRG NNP cord-015021-pol2qm74 7932 15 , , , cord-015021-pol2qm74 7932 16 day day NN cord-015021-pol2qm74 7932 17 1:8 1:8 CD cord-015021-pol2qm74 7932 18 ml ml NNS cord-015021-pol2qm74 7932 19 / / SYM cord-015021-pol2qm74 7932 20 kg kg NNP cord-015021-pol2qm74 7932 21 , , , cord-015021-pol2qm74 7932 22 day day NN cord-015021-pol2qm74 7932 23 2:4 2:4 CD cord-015021-pol2qm74 7932 24 ml ml NN cord-015021-pol2qm74 7932 25 / / SYM cord-015021-pol2qm74 7932 26 kg kg NNP cord-015021-pol2qm74 7932 27 ) ) -RRB- cord-015021-pol2qm74 7932 28 . . . cord-015021-pol2qm74 7933 1 Second second JJ cord-015021-pol2qm74 7933 2 study study NN cord-015021-pol2qm74 7933 3 period period NN cord-015021-pol2qm74 7934 1 ( ( -LRB- cord-015021-pol2qm74 7934 2 n=25 n=25 NNP cord-015021-pol2qm74 7934 3 ) ) -RRB- cord-015021-pol2qm74 7934 4 : : : cord-015021-pol2qm74 7935 1 IgGMA IgGMA NNP cord-015021-pol2qm74 7936 1 ( ( -LRB- cord-015021-pol2qm74 7936 2 Pentaglobin Pentaglobin NNP cord-015021-pol2qm74 7936 3 R R NNP cord-015021-pol2qm74 7936 4 , , , cord-015021-pol2qm74 7936 5 Biotest Biotest NNP cord-015021-pol2qm74 7936 6 , , , cord-015021-pol2qm74 7936 7 Dreieich Dreieich NNP cord-015021-pol2qm74 7936 8 , , , cord-015021-pol2qm74 7936 9 FRG FRG NNP cord-015021-pol2qm74 7936 10 , , , cord-015021-pol2qm74 7936 11 5 5 CD cord-015021-pol2qm74 7936 12 ml ml NN cord-015021-pol2qm74 7936 13 / / SYM cord-015021-pol2qm74 7936 14 kg kg NNS cord-015021-pol2qm74 7936 15 on on IN cord-015021-pol2qm74 7936 16 days day NNS cord-015021-pol2qm74 7936 17 1 1 CD cord-015021-pol2qm74 7936 18 to to IN cord-015021-pol2qm74 7936 19 3 3 CD cord-015021-pol2qm74 7936 20 ) ) -RRB- cord-015021-pol2qm74 7936 21 . . . cord-015021-pol2qm74 7937 1 Results result NNS cord-015021-pol2qm74 7937 2 : : : cord-015021-pol2qm74 7938 1 Ig Ig NNP cord-015021-pol2qm74 7938 2 pat pat NNP cord-015021-pol2qm74 7938 3 . . . cord-015021-pol2qm74 7939 1 and and CC cord-015021-pol2qm74 7939 2 con con NNP cord-015021-pol2qm74 7939 3 . . NNP cord-015021-pol2qm74 7939 4 were be VBD cord-015021-pol2qm74 7939 5 comparable comparable JJ cord-015021-pol2qm74 7939 6 in in IN cord-015021-pol2qm74 7939 7 demographic demographic JJ cord-015021-pol2qm74 7939 8 data datum NNS cord-015021-pol2qm74 7939 9 , , , cord-015021-pol2qm74 7939 10 operation operation NN cord-015021-pol2qm74 7939 11 characteristics characteristic NNS cord-015021-pol2qm74 7939 12 and and CC cord-015021-pol2qm74 7939 13 baseline baseline JJ cord-015021-pol2qm74 7939 14 disease disease NN cord-015021-pol2qm74 7939 15 severity severity NN cord-015021-pol2qm74 7939 16 LAP LAP NNP cord-015021-pol2qm74 7939 17 and and CC cord-015021-pol2qm74 7939 18 Elebute Elebute NNP cord-015021-pol2qm74 7939 19 sepsis sepsis NN cord-015021-pol2qm74 7939 20 scores score NNS cord-015021-pol2qm74 7939 21 ) ) -RRB- cord-015021-pol2qm74 7939 22 . . . cord-015021-pol2qm74 7940 1 In in IN cord-015021-pol2qm74 7940 2 contrast contrast NN cord-015021-pol2qm74 7940 3 to to IN cord-015021-pol2qm74 7940 4 con con NNP cord-015021-pol2qm74 7940 5 . . . cord-015021-pol2qm74 7941 1 ( ( -LRB- cord-015021-pol2qm74 7941 2 risk risk NN cord-015021-pol2qm74 7941 3 : : : cord-015021-pol2qm74 7941 4 n=21 n=21 NN cord-015021-pol2qm74 7941 5 , , , cord-015021-pol2qm74 7941 6 high high JJ cord-015021-pol2qm74 7941 7 - - HYPH cord-015021-pol2qm74 7941 8 risk risk NN cord-015021-pol2qm74 7941 9 : : : cord-015021-pol2qm74 7942 1 n-21 n-21 NNP cord-015021-pol2qm74 7942 2 ) ) -RRB- cord-015021-pol2qm74 7942 3 , , , cord-015021-pol2qm74 7942 4 the the DT cord-015021-pol2qm74 7942 5 Ig Ig NNP cord-015021-pol2qm74 7942 6 pat pat NNP cord-015021-pol2qm74 7942 7 . . NNP cord-015021-pol2qm74 7942 8 showed show VBD cord-015021-pol2qm74 7942 9 a a DT cord-015021-pol2qm74 7942 10 marked mark VBN cord-015021-pol2qm74 7942 11 improvement improvement NN cord-015021-pol2qm74 7942 12 in in IN cord-015021-pol2qm74 7942 13 disease disease NN cord-015021-pol2qm74 7942 14 severity severity NN cord-015021-pol2qm74 7942 15 ( ( -LRB- cord-015021-pol2qm74 7942 16 fall fall NN cord-015021-pol2qm74 7942 17 in in IN cord-015021-pol2qm74 7942 18 AP AP NNP cord-015021-pol2qm74 7942 19 ) ) -RRB- cord-015021-pol2qm74 7942 20 , , , cord-015021-pol2qm74 7942 21 especially especially RB cord-015021-pol2qm74 7942 22 in in IN cord-015021-pol2qm74 7942 23 the the DT cord-015021-pol2qm74 7942 24 high high JJ cord-015021-pol2qm74 7942 25 - - HYPH cord-015021-pol2qm74 7942 26 risk risk NN cord-015021-pol2qm74 7942 27 group group NN cord-015021-pol2qm74 7942 28 ( ( -LRB- cord-015021-pol2qm74 7942 29 IgG IgG NNP cord-015021-pol2qm74 7942 30 , , , cord-015021-pol2qm74 7942 31 n=26 n=26 RB cord-015021-pol2qm74 7942 32 : : : cord-015021-pol2qm74 7942 33 p p NN cord-015021-pol2qm74 7942 34 < < XX cord-015021-pol2qm74 7942 35 O.05 o.05 UH cord-015021-pol2qm74 7942 36 ; ; . cord-015021-pol2qm74 7942 37 IgGMA IgGMA NNP cord-015021-pol2qm74 7942 38 , , , cord-015021-pol2qm74 7943 1 n=13 n=13 NNP cord-015021-pol2qm74 7943 2 : : : cord-015021-pol2qm74 7943 3 p p NN cord-015021-pol2qm74 7943 4 : : : cord-015021-pol2qm74 7943 5 0.08 0.08 CD cord-015021-pol2qm74 7943 6 ) ) -RRB- cord-015021-pol2qm74 7943 7 . . . cord-015021-pol2qm74 7944 1 In in IN cord-015021-pol2qm74 7944 2 this this DT cord-015021-pol2qm74 7944 3 group group NN cord-015021-pol2qm74 7944 4 , , , cord-015021-pol2qm74 7944 5 Ig Ig NNP cord-015021-pol2qm74 7944 6 led lead VBD cord-015021-pol2qm74 7944 7 to to IN cord-015021-pol2qm74 7944 8 higher high JJR cord-015021-pol2qm74 7944 9 ( ( -LRB- cord-015021-pol2qm74 7944 10 p<0.05 p<0.05 CD cord-015021-pol2qm74 7944 11 ) ) -RRB- cord-015021-pol2qm74 7944 12 response response NN cord-015021-pol2qm74 7944 13 rates rate NNS cord-015021-pol2qm74 7944 14 , , , cord-015021-pol2qm74 7944 15 defined define VBN cord-015021-pol2qm74 7944 16 as as IN cord-015021-pol2qm74 7944 17 an an DT cord-015021-pol2qm74 7944 18 AP AP NNP cord-015021-pol2qm74 7944 19 score score NN cord-015021-pol2qm74 7944 20 decrease decrease VB cord-015021-pol2qm74 7944 21 ->7 ->7 NN cord-015021-pol2qm74 7944 22 within within IN cord-015021-pol2qm74 7944 23 four four CD cord-015021-pol2qm74 7944 24 days day NNS cord-015021-pol2qm74 7944 25 ( ( -LRB- cord-015021-pol2qm74 7944 26 IgG igg NN cord-015021-pol2qm74 7944 27 : : : cord-015021-pol2qm74 7944 28 54 54 CD cord-015021-pol2qm74 7944 29 % % NN cord-015021-pol2qm74 7944 30 , , , cord-015021-pol2qm74 7944 31 IgGMA iggma NN cord-015021-pol2qm74 7944 32 : : : cord-015021-pol2qm74 7944 33 62 62 CD cord-015021-pol2qm74 7944 34 % % NN cord-015021-pol2qm74 7944 35 ; ; : cord-015021-pol2qm74 7944 36 con con NN cord-015021-pol2qm74 7944 37 . . NN cord-015021-pol2qm74 7944 38 : : : cord-015021-pol2qm74 7944 39 19 19 CD cord-015021-pol2qm74 7944 40 % % NN cord-015021-pol2qm74 7944 41 ) ) -RRB- cord-015021-pol2qm74 7944 42 , , , cord-015021-pol2qm74 7944 43 and and CC cord-015021-pol2qm74 7944 44 reduction reduction NN cord-015021-pol2qm74 7944 45 in in IN cord-015021-pol2qm74 7944 46 mortality mortality NN cord-015021-pol2qm74 7944 47 ( ( -LRB- cord-015021-pol2qm74 7944 48 IgG IgG NNP cord-015021-pol2qm74 7944 49 : : : cord-015021-pol2qm74 7944 50 46 46 CD cord-015021-pol2qm74 7944 51 % % NN cord-015021-pol2qm74 7944 52 , , , cord-015021-pol2qm74 7944 53 IgGMA iggma NN cord-015021-pol2qm74 7944 54 : : : cord-015021-pol2qm74 7944 55 46 46 CD cord-015021-pol2qm74 7944 56 % % NN cord-015021-pol2qm74 7944 57 ; ; : cord-015021-pol2qm74 7944 58 con con NN cord-015021-pol2qm74 7944 59 . . NN cord-015021-pol2qm74 7944 60 : : : cord-015021-pol2qm74 7944 61 76 76 CD cord-015021-pol2qm74 7944 62 % % NN cord-015021-pol2qm74 7944 63 ) ) -RRB- cord-015021-pol2qm74 7944 64 , , , cord-015021-pol2qm74 7944 65 statistically statistically RB cord-015021-pol2qm74 7944 66 significant significant JJ cord-015021-pol2qm74 7944 67 ( ( -LRB- cord-015021-pol2qm74 7944 68 p<0.05 p<0.05 CD cord-015021-pol2qm74 7944 69 ) ) -RRB- cord-015021-pol2qm74 7944 70 for for IN cord-015021-pol2qm74 7944 71 Ig Ig NNP cord-015021-pol2qm74 7944 72 treatment treatment NN cord-015021-pol2qm74 7944 73 as as IN cord-015021-pol2qm74 7944 74 a a DT cord-015021-pol2qm74 7944 75 whole whole NN cord-015021-pol2qm74 7944 76 ( ( -LRB- cord-015021-pol2qm74 7944 77 IgG igg NN cord-015021-pol2qm74 7944 78 and and CC cord-015021-pol2qm74 7944 79 IgGMA IgGMA NNP cord-015021-pol2qm74 7944 80 ) ) -RRB- cord-015021-pol2qm74 7944 81 . . . cord-015021-pol2qm74 7945 1 Conclusion conclusion NN cord-015021-pol2qm74 7945 2 : : : cord-015021-pol2qm74 7946 1 Given give VBN cord-015021-pol2qm74 7946 2 the the DT cord-015021-pol2qm74 7946 3 good good JJ cord-015021-pol2qm74 7946 4 comparability comparability NN cord-015021-pol2qm74 7946 5 of of IN cord-015021-pol2qm74 7946 6 the the DT cord-015021-pol2qm74 7946 7 study study NN cord-015021-pol2qm74 7946 8 groups group NNS cord-015021-pol2qm74 7946 9 , , , cord-015021-pol2qm74 7946 10 our -PRON- PRP$ cord-015021-pol2qm74 7946 11 results result NNS cord-015021-pol2qm74 7946 12 indicate indicate VBP cord-015021-pol2qm74 7946 13 , , , cord-015021-pol2qm74 7946 14 despite despite IN cord-015021-pol2qm74 7946 15 the the DT cord-015021-pol2qm74 7946 16 non non JJ cord-015021-pol2qm74 7946 17 - - JJ cord-015021-pol2qm74 7946 18 randomized randomized JJ cord-015021-pol2qm74 7946 19 design design NN cord-015021-pol2qm74 7946 20 , , , cord-015021-pol2qm74 7946 21 that that IN cord-015021-pol2qm74 7946 22 early early JJ cord-015021-pol2qm74 7946 23 supplemental supplemental JJ cord-015021-pol2qm74 7946 24 Ig ig JJ cord-015021-pol2qm74 7946 25 treatment treatment NN cord-015021-pol2qm74 7946 26 can can MD cord-015021-pol2qm74 7946 27 improve improve VB cord-015021-pol2qm74 7946 28 disease disease NN cord-015021-pol2qm74 7946 29 severity severity NN cord-015021-pol2qm74 7946 30 and and CC cord-015021-pol2qm74 7946 31 may may MD cord-015021-pol2qm74 7946 32 improve improve VB cord-015021-pol2qm74 7946 33 prognosis prognosis NN cord-015021-pol2qm74 7946 34 in in IN cord-015021-pol2qm74 7946 35 prospectively prospectively RB cord-015021-pol2qm74 7946 36 APACHE APACHE NNP cord-015021-pol2qm74 7946 37 II II NNP cord-015021-pol2qm74 7946 38 score score NN cord-015021-pol2qm74 7946 39 - - HYPH cord-015021-pol2qm74 7946 40 identified identify VBN cord-015021-pol2qm74 7946 41 high high JJ cord-015021-pol2qm74 7946 42 - - HYPH cord-015021-pol2qm74 7946 43 risk risk NN cord-015021-pol2qm74 7946 44 patients patient NNS cord-015021-pol2qm74 7946 45 after after IN cord-015021-pol2qm74 7946 46 cardiac cardiac JJ cord-015021-pol2qm74 7946 47 surgery surgery NN cord-015021-pol2qm74 7946 48 . . . cord-015021-pol2qm74 7947 1 Objective objective JJ cord-015021-pol2qm74 7947 2 . . . cord-015021-pol2qm74 7948 1 Elevated elevated JJ cord-015021-pol2qm74 7948 2 plasma plasma NN cord-015021-pol2qm74 7948 3 levels level NNS cord-015021-pol2qm74 7948 4 of of IN cord-015021-pol2qm74 7948 5 Endothelin Endothelin NNP cord-015021-pol2qm74 7948 6 ( ( -LRB- cord-015021-pol2qm74 7948 7 ET ET NNP cord-015021-pol2qm74 7948 8 ) ) -RRB- cord-015021-pol2qm74 7948 9 have have VBP cord-015021-pol2qm74 7948 10 been be VBN cord-015021-pol2qm74 7948 11 demonstrated demonstrate VBN cord-015021-pol2qm74 7948 12 in in IN cord-015021-pol2qm74 7948 13 both both CC cord-015021-pol2qm74 7948 14 experimental experimental JJ cord-015021-pol2qm74 7948 15 and and CC cord-015021-pol2qm74 7948 16 human human JJ cord-015021-pol2qm74 7948 17 sepsis sepsis NN cord-015021-pol2qm74 7948 18 . . . cord-015021-pol2qm74 7949 1 ET ET NNP cord-015021-pol2qm74 7949 2 has have VBZ cord-015021-pol2qm74 7949 3 been be VBN cord-015021-pol2qm74 7949 4 proposed propose VBN cord-015021-pol2qm74 7949 5 as as IN cord-015021-pol2qm74 7949 6 a a DT cord-015021-pol2qm74 7949 7 sepsis sepsis NN cord-015021-pol2qm74 7949 8 mediator mediator NN cord-015021-pol2qm74 7949 9 leading lead VBG cord-015021-pol2qm74 7949 10 to to IN cord-015021-pol2qm74 7949 11 vasoconstriction vasoconstriction NN cord-015021-pol2qm74 7949 12 with with IN cord-015021-pol2qm74 7949 13 tissue tissue NN cord-015021-pol2qm74 7949 14 hypoperfusion hypoperfusion NN cord-015021-pol2qm74 7949 15 and and CC cord-015021-pol2qm74 7949 16 organ organ NN cord-015021-pol2qm74 7949 17 failure failure NN cord-015021-pol2qm74 7949 18 . . . cord-015021-pol2qm74 7950 1 The the DT cord-015021-pol2qm74 7950 2 aim aim NN cord-015021-pol2qm74 7950 3 of of IN cord-015021-pol2qm74 7950 4 the the DT cord-015021-pol2qm74 7950 5 study study NN cord-015021-pol2qm74 7950 6 was be VBD cord-015021-pol2qm74 7950 7 to to TO cord-015021-pol2qm74 7950 8 determine determine VB cord-015021-pol2qm74 7950 9 the the DT cord-015021-pol2qm74 7950 10 effects effect NNS cord-015021-pol2qm74 7950 11 of of IN cord-015021-pol2qm74 7950 12 sepsis sepsis NN cord-015021-pol2qm74 7950 13 treatment treatment NN cord-015021-pol2qm74 7950 14 with with IN cord-015021-pol2qm74 7950 15 volume volume NN cord-015021-pol2qm74 7950 16 resuscitation resuscitation NN cord-015021-pol2qm74 7950 17 , , , cord-015021-pol2qm74 7950 18 antibiotics antibiotic NNS cord-015021-pol2qm74 7950 19 and and CC cord-015021-pol2qm74 7950 20 the the DT cord-015021-pol2qm74 7950 21 anti anti JJ cord-015021-pol2qm74 7950 22 - - JJ cord-015021-pol2qm74 7950 23 LPS lps JJ cord-015021-pol2qm74 7950 24 monoclonal monoclonal JJ cord-015021-pol2qm74 7950 25 antibody antibody NN cord-015021-pol2qm74 7950 26 ES ES NNP cord-015021-pol2qm74 7950 27 ® ® NNP cord-015021-pol2qm74 7950 28 on on IN cord-015021-pol2qm74 7950 29 big big JJ cord-015021-pol2qm74 7950 30 ET et NN cord-015021-pol2qm74 7950 31 and and CC cord-015021-pol2qm74 7950 32 active active JJ cord-015021-pol2qm74 7950 33 , , , cord-015021-pol2qm74 7950 34 21 21 CD cord-015021-pol2qm74 7950 35 aminoacids aminoacid NNS cord-015021-pol2qm74 7950 36 ET ET NNP cord-015021-pol2qm74 7950 37 ( ( -LRB- cord-015021-pol2qm74 7950 38 ET ET NNP cord-015021-pol2qm74 7950 39 21 21 CD cord-015021-pol2qm74 7950 40 ) ) -RRB- cord-015021-pol2qm74 7950 41 in in IN cord-015021-pol2qm74 7950 42 rat rat NN cord-015021-pol2qm74 7950 43 abdominal abdominal JJ cord-015021-pol2qm74 7950 44 sepsis sepsis NN cord-015021-pol2qm74 7950 45 . . . cord-015021-pol2qm74 7951 1 Methods method NNS cord-015021-pol2qm74 7951 2 . . . cord-015021-pol2qm74 7952 1 Lethal lethal JJ cord-015021-pol2qm74 7952 2 peritonitis peritonitis NN cord-015021-pol2qm74 7952 3 was be VBD cord-015021-pol2qm74 7952 4 induced induce VBN cord-015021-pol2qm74 7952 5 with with IN cord-015021-pol2qm74 7952 6 a a DT cord-015021-pol2qm74 7952 7 4 4 CD cord-015021-pol2qm74 7952 8 mm mm NN cord-015021-pol2qm74 7952 9 coecal coecal JJ cord-015021-pol2qm74 7952 10 perforation perforation NN cord-015021-pol2qm74 7952 11 ( ( -LRB- cord-015021-pol2qm74 7952 12 CP CP NNP cord-015021-pol2qm74 7952 13 ) ) -RRB- cord-015021-pol2qm74 7952 14 in in IN cord-015021-pol2qm74 7952 15 male male JJ cord-015021-pol2qm74 7952 16 Wistar Wistar NNP cord-015021-pol2qm74 7952 17 rats rat NNS cord-015021-pol2qm74 7952 18 . . . cord-015021-pol2qm74 7953 1 Plasma plasma NN cord-015021-pol2qm74 7953 2 levels level NNS cord-015021-pol2qm74 7953 3 of of IN cord-015021-pol2qm74 7953 4 big big JJ cord-015021-pol2qm74 7953 5 ET et NN cord-015021-pol2qm74 7953 6 and and CC cord-015021-pol2qm74 7953 7 ET ET NNP cord-015021-pol2qm74 7953 8 21 21 CD cord-015021-pol2qm74 7953 9 were be VBD cord-015021-pol2qm74 7953 10 determined determine VBN cord-015021-pol2qm74 7953 11 with with IN cord-015021-pol2qm74 7953 12 Amersham Amersham NNP cord-015021-pol2qm74 7953 13 TM TM NNP cord-015021-pol2qm74 7953 14 Endothelin Endothelin NNP cord-015021-pol2qm74 7953 15 RIAs RIAs NNP cord-015021-pol2qm74 7953 16 4 4 CD cord-015021-pol2qm74 7953 17 , , , cord-015021-pol2qm74 7953 18 8 8 CD cord-015021-pol2qm74 7953 19 and and CC cord-015021-pol2qm74 7953 20 12 12 CD cord-015021-pol2qm74 7953 21 h h NN cord-015021-pol2qm74 7953 22 after after IN cord-015021-pol2qm74 7953 23 sepsis sepsis NN cord-015021-pol2qm74 7953 24 induction induction NN cord-015021-pol2qm74 7953 25 . . . cord-015021-pol2qm74 7954 1 Experimental experimental JJ cord-015021-pol2qm74 7954 2 groups group NNS cord-015021-pol2qm74 7954 3 : : : cord-015021-pol2qm74 7955 1 1 1 LS cord-015021-pol2qm74 7955 2 . . . cord-015021-pol2qm74 7956 1 CP cp NN cord-015021-pol2qm74 7956 2 control control NN cord-015021-pol2qm74 7956 3 , , , cord-015021-pol2qm74 7956 4 2 2 CD cord-015021-pol2qm74 7956 5 . . . cord-015021-pol2qm74 7957 1 Volume volume NN cord-015021-pol2qm74 7957 2 replacement replacement NN cord-015021-pol2qm74 7957 3 ( ( -LRB- cord-015021-pol2qm74 7957 4 VR VR NNP cord-015021-pol2qm74 7957 5 ) ) -RRB- cord-015021-pol2qm74 7957 6 ; ; : cord-015021-pol2qm74 7957 7 0,9 0,9 CD cord-015021-pol2qm74 7957 8 % % NN cord-015021-pol2qm74 7957 9 saline saline NN cord-015021-pol2qm74 7957 10 10 10 CD cord-015021-pol2qm74 7958 1 ml ml NNP cord-015021-pol2qm74 7958 2 / / SYM cord-015021-pol2qm74 7958 3 kg kg NNP cord-015021-pol2qm74 7958 4 / / SYM cord-015021-pol2qm74 7958 5 h h NN cord-015021-pol2qm74 7958 6 continous continous JJ cord-015021-pol2qm74 7958 7 iv iv NNP cord-015021-pol2qm74 7958 8 infusion infusion NN cord-015021-pol2qm74 7958 9 started start VBD cord-015021-pol2qm74 7958 10 after after IN cord-015021-pol2qm74 7958 11 2 2 CD cord-015021-pol2qm74 7958 12 h h NN cord-015021-pol2qm74 7958 13 , , , cord-015021-pol2qm74 7958 14 3 3 CD cord-015021-pol2qm74 7958 15 . . . cord-015021-pol2qm74 7959 1 Antibiotic antibiotic JJ cord-015021-pol2qm74 7959 2 ; ; : cord-015021-pol2qm74 7959 3 imipenem imipenem NNP cord-015021-pol2qm74 7959 4 40 40 CD cord-015021-pol2qm74 7959 5 mg mg NNP cord-015021-pol2qm74 7959 6 / / SYM cord-015021-pol2qm74 7959 7 kg kg NNP cord-015021-pol2qm74 7959 8 iv iv NNP cord-015021-pol2qm74 7959 9 after after IN cord-015021-pol2qm74 7959 10 2 2 CD cord-015021-pol2qm74 7959 11 h h NN cord-015021-pol2qm74 7959 12 , , , cord-015021-pol2qm74 7959 13 4 4 CD cord-015021-pol2qm74 7959 14 . . . cord-015021-pol2qm74 7960 1 E5 E5 NNP cord-015021-pol2qm74 7960 2 ® ® NNP cord-015021-pol2qm74 7960 3 ; ; : cord-015021-pol2qm74 7960 4 10 10 CD cord-015021-pol2qm74 7960 5 mg mg NN cord-015021-pol2qm74 7960 6 / / SYM cord-015021-pol2qm74 7960 7 kg kg NNP cord-015021-pol2qm74 7961 1 iv iv LS cord-015021-pol2qm74 7961 2 after after IN cord-015021-pol2qm74 7961 3 2 2 CD cord-015021-pol2qm74 7961 4 h h NN cord-015021-pol2qm74 7961 5 , , , cord-015021-pol2qm74 7961 6 5 5 CD cord-015021-pol2qm74 7961 7 . . . cord-015021-pol2qm74 7962 1 VR VR NNP cord-015021-pol2qm74 7962 2 + + CC cord-015021-pol2qm74 7962 3 imipenem imipenem NNP cord-015021-pol2qm74 7963 1 + + CC cord-015021-pol2qm74 7964 1 ES ES NNP cord-015021-pol2qm74 7964 2 ® ® NNP cord-015021-pol2qm74 7964 3 after after IN cord-015021-pol2qm74 7964 4 2 2 CD cord-015021-pol2qm74 7964 5 h. h. NN cord-015021-pol2qm74 7964 6 Results result NNS cord-015021-pol2qm74 7964 7 . . . cord-015021-pol2qm74 7965 1 High high JJ cord-015021-pol2qm74 7965 2 concentrations concentration NNS cord-015021-pol2qm74 7965 3 of of IN cord-015021-pol2qm74 7965 4 both both DT cord-015021-pol2qm74 7965 5 big big JJ cord-015021-pol2qm74 7965 6 ET ET NNP cord-015021-pol2qm74 7965 7 and and CC cord-015021-pol2qm74 7965 8 ET ET NNP cord-015021-pol2qm74 7965 9 21 21 CD cord-015021-pol2qm74 7965 10 could could MD cord-015021-pol2qm74 7965 11 be be VB cord-015021-pol2qm74 7965 12 demonstrated demonstrate VBN cord-015021-pol2qm74 7965 13 after after IN cord-015021-pol2qm74 7965 14 2 2 CD cord-015021-pol2qm74 7965 15 h h NN cord-015021-pol2qm74 7965 16 and and CC cord-015021-pol2qm74 7965 17 lasting last VBG cord-015021-pol2qm74 7965 18 for for IN cord-015021-pol2qm74 7965 19 12 12 CD cord-015021-pol2qm74 7965 20 h h NN cord-015021-pol2qm74 7965 21 after after IN cord-015021-pol2qm74 7965 22 CP CP NNP cord-015021-pol2qm74 7965 23 . . . cord-015021-pol2qm74 7966 1 Neither neither DT cord-015021-pol2qm74 7966 2 volume volume NN cord-015021-pol2qm74 7966 3 replacement replacement NN cord-015021-pol2qm74 7966 4 nor nor CC cord-015021-pol2qm74 7966 5 imipenem imipenem NNP cord-015021-pol2qm74 7966 6 did do VBD cord-015021-pol2qm74 7966 7 influence influence VB cord-015021-pol2qm74 7966 8 the the DT cord-015021-pol2qm74 7966 9 elevated elevated JJ cord-015021-pol2qm74 7966 10 plasma plasma NN cord-015021-pol2qm74 7966 11 ET et NN cord-015021-pol2qm74 7966 12 . . . cord-015021-pol2qm74 7966 13 E5 E5 NNP cord-015021-pol2qm74 7967 1 ® ® VB cord-015021-pol2qm74 7967 2 significantly significantly RB cord-015021-pol2qm74 7967 3 reduced reduce VBN cord-015021-pol2qm74 7967 4 ET ET NNP cord-015021-pol2qm74 7967 5 21 21 CD cord-015021-pol2qm74 7967 6 both both DT cord-015021-pol2qm74 7967 7 4 4 CD cord-015021-pol2qm74 7967 8 , , , cord-015021-pol2qm74 7967 9 8 8 CD cord-015021-pol2qm74 7967 10 and and CC cord-015021-pol2qm74 7967 11 12 12 CD cord-015021-pol2qm74 7967 12 h h NN cord-015021-pol2qm74 7967 13 after after IN cord-015021-pol2qm74 7967 14 sepsis sepsis NN cord-015021-pol2qm74 7967 15 induction induction NN cord-015021-pol2qm74 7967 16 , , , cord-015021-pol2qm74 7967 17 but but CC cord-015021-pol2qm74 7967 18 did do VBD cord-015021-pol2qm74 7967 19 not not RB cord-015021-pol2qm74 7967 20 reduce reduce VB cord-015021-pol2qm74 7967 21 big big JJ cord-015021-pol2qm74 7967 22 ET et NN cord-015021-pol2qm74 7967 23 . . . cord-015021-pol2qm74 7968 1 When when WRB cord-015021-pol2qm74 7968 2 ES ES NNP cord-015021-pol2qm74 7968 3 ® ® NNP cord-015021-pol2qm74 7968 4 was be VBD cord-015021-pol2qm74 7968 5 combined combine VBN cord-015021-pol2qm74 7968 6 with with IN cord-015021-pol2qm74 7968 7 VR VR NNP cord-015021-pol2qm74 7968 8 and and CC cord-015021-pol2qm74 7968 9 imipenem imipenem NNP cord-015021-pol2qm74 7968 10 , , , cord-015021-pol2qm74 7968 11 reduction reduction NN cord-015021-pol2qm74 7968 12 of of IN cord-015021-pol2qm74 7968 13 ET ET NNP cord-015021-pol2qm74 7968 14 21 21 CD cord-015021-pol2qm74 7968 15 was be VBD cord-015021-pol2qm74 7968 16 the the DT cord-015021-pol2qm74 7968 17 same same JJ cord-015021-pol2qm74 7968 18 as as IN cord-015021-pol2qm74 7968 19 for for IN cord-015021-pol2qm74 7968 20 E5 e5 NN cord-015021-pol2qm74 7969 1 ® ® VB cord-015021-pol2qm74 7969 2 alone alone RB cord-015021-pol2qm74 7969 3 . . . cord-015021-pol2qm74 7970 1 These these DT cord-015021-pol2qm74 7970 2 results result NNS cord-015021-pol2qm74 7970 3 strongly strongly RB cord-015021-pol2qm74 7970 4 suggest suggest VBP cord-015021-pol2qm74 7970 5 that that IN cord-015021-pol2qm74 7970 6 bacteria bacteria NNS cord-015021-pol2qm74 7970 7 and and CC cord-015021-pol2qm74 7970 8 hypovolemia hypovolemia NN cord-015021-pol2qm74 7970 9 per per FW cord-015021-pol2qm74 7970 10 se se FW cord-015021-pol2qm74 7970 11 are be VBP cord-015021-pol2qm74 7970 12 not not RB cord-015021-pol2qm74 7970 13 decisive decisive JJ cord-015021-pol2qm74 7970 14 stimuli stimulus NNS cord-015021-pol2qm74 7970 15 for for IN cord-015021-pol2qm74 7970 16 ET ET NNP cord-015021-pol2qm74 7970 17 production production NN cord-015021-pol2qm74 7970 18 during during IN cord-015021-pol2qm74 7970 19 sepsis sepsis NN cord-015021-pol2qm74 7970 20 . . . cord-015021-pol2qm74 7971 1 E5 E5 NNP cord-015021-pol2qm74 7972 1 ® ® NNP cord-015021-pol2qm74 7972 2 reduces reduce VBZ cord-015021-pol2qm74 7972 3 circulating circulate VBG cord-015021-pol2qm74 7972 4 LPS LPS NNP cord-015021-pol2qm74 7972 5 and and CC cord-015021-pol2qm74 7972 6 TNF TNF NNP cord-015021-pol2qm74 7972 7 which which WDT cord-015021-pol2qm74 7972 8 is be VBZ cord-015021-pol2qm74 7972 9 the the DT cord-015021-pol2qm74 7972 10 probable probable JJ cord-015021-pol2qm74 7972 11 mechanism mechanism NN cord-015021-pol2qm74 7972 12 of of IN cord-015021-pol2qm74 7972 13 the the DT cord-015021-pol2qm74 7972 14 suppressed suppress VBN cord-015021-pol2qm74 7972 15 ET ET NNP cord-015021-pol2qm74 7972 16 21 21 CD cord-015021-pol2qm74 7972 17 synthesis synthesis NN cord-015021-pol2qm74 7972 18 . . . cord-015021-pol2qm74 7973 1 The the DT cord-015021-pol2qm74 7973 2 unaltered unaltered JJ cord-015021-pol2qm74 7973 3 big big JJ cord-015021-pol2qm74 7973 4 ET ET NNP cord-015021-pol2qm74 7973 5 fraction fraction NN cord-015021-pol2qm74 7973 6 after after IN cord-015021-pol2qm74 7973 7 E5 e5 NN cord-015021-pol2qm74 7974 1 ® ® NNP cord-015021-pol2qm74 7974 2 treatment treatment NN cord-015021-pol2qm74 7974 3 indicates indicate VBZ cord-015021-pol2qm74 7974 4 conversion conversion NN cord-015021-pol2qm74 7974 5 of of IN cord-015021-pol2qm74 7974 6 big big JJ cord-015021-pol2qm74 7974 7 ET ET NNP cord-015021-pol2qm74 7974 8 to to IN cord-015021-pol2qm74 7974 9 ET ET NNP cord-015021-pol2qm74 7974 10 21 21 CD cord-015021-pol2qm74 7974 11 as as IN cord-015021-pol2qm74 7974 12 the the DT cord-015021-pol2qm74 7974 13 site site NN cord-015021-pol2qm74 7974 14 of of IN cord-015021-pol2qm74 7974 15 action action NN cord-015021-pol2qm74 7974 16 responsible responsible JJ cord-015021-pol2qm74 7974 17 for for IN cord-015021-pol2qm74 7974 18 reduced reduce VBN cord-015021-pol2qm74 7974 19 ET ET NNP cord-015021-pol2qm74 7974 20 21 21 CD cord-015021-pol2qm74 7974 21 . . . cord-015021-pol2qm74 7975 1 Conclusion conclusion NN cord-015021-pol2qm74 7975 2 . . . cord-015021-pol2qm74 7976 1 Lethal lethal JJ cord-015021-pol2qm74 7976 2 peritonitis peritonitis NN cord-015021-pol2qm74 7976 3 in in IN cord-015021-pol2qm74 7976 4 the the DT cord-015021-pol2qm74 7976 5 rat rat NN cord-015021-pol2qm74 7976 6 is be VBZ cord-015021-pol2qm74 7976 7 followed follow VBN cord-015021-pol2qm74 7976 8 by by IN cord-015021-pol2qm74 7976 9 elevated elevated JJ cord-015021-pol2qm74 7976 10 plasma plasma NN cord-015021-pol2qm74 7976 11 levels level NNS cord-015021-pol2qm74 7976 12 of of IN cord-015021-pol2qm74 7976 13 big big JJ cord-015021-pol2qm74 7976 14 ET et NN cord-015021-pol2qm74 7976 15 and and CC cord-015021-pol2qm74 7976 16 ET ET NNP cord-015021-pol2qm74 7976 17 21 21 CD cord-015021-pol2qm74 7976 18 . . . cord-015021-pol2qm74 7977 1 E5 E5 NNP cord-015021-pol2qm74 7978 1 ® ® . cord-015021-pol2qm74 7979 1 anti anti JJ cord-015021-pol2qm74 7979 2 - - JJ cord-015021-pol2qm74 7979 3 LPS lps JJ cord-015021-pol2qm74 7979 4 antibody antibody NN cord-015021-pol2qm74 7979 5 significantly significantly RB cord-015021-pol2qm74 7979 6 reduces reduce VBZ cord-015021-pol2qm74 7979 7 plasma plasma NN cord-015021-pol2qm74 7979 8 ET ET NNP cord-015021-pol2qm74 7979 9 21 21 CD cord-015021-pol2qm74 7979 10 while while IN cord-015021-pol2qm74 7979 11 volume volume NN cord-015021-pol2qm74 7979 12 resuscitation resuscitation NN cord-015021-pol2qm74 7979 13 and and CC cord-015021-pol2qm74 7979 14 antibiotics antibiotic NNS cord-015021-pol2qm74 7979 15 failed fail VBD cord-015021-pol2qm74 7979 16 to to TO cord-015021-pol2qm74 7979 17 do do VB cord-015021-pol2qm74 7979 18 the the DT cord-015021-pol2qm74 7979 19 same same JJ cord-015021-pol2qm74 7979 20 . . . cord-015021-pol2qm74 7980 1 ES ES NNP cord-015021-pol2qm74 7980 2 ® ® NNP cord-015021-pol2qm74 7980 3 did do VBD cord-015021-pol2qm74 7980 4 not not RB cord-015021-pol2qm74 7980 5 reduce reduce VB cord-015021-pol2qm74 7980 6 plasma plasma NN cord-015021-pol2qm74 7980 7 big big JJ cord-015021-pol2qm74 7980 8 ET et NN cord-015021-pol2qm74 7980 9 . . . cord-015021-pol2qm74 7981 1 PMX pmx NN cord-015021-pol2qm74 7981 2 treatment treatment NN cord-015021-pol2qm74 7981 3 on on IN cord-015021-pol2qm74 7981 4 severe severe JJ cord-015021-pol2qm74 7981 5 endotoxemia endotoxemia NN cord-015021-pol2qm74 7981 6 with with IN cord-015021-pol2qm74 7981 7 multiple multiple JJ cord-015021-pol2qm74 7981 8 organ organ NN cord-015021-pol2qm74 7981 9 failure failure NN cord-015021-pol2qm74 7981 10 was be VBD cord-015021-pol2qm74 7981 11 safety safety NN cord-015021-pol2qm74 7981 12 and and CC cord-015021-pol2qm74 7981 13 effect effect NN cord-015021-pol2qm74 7981 14 in in IN cord-015021-pol2qm74 7981 15 prognosis prognosis NN cord-015021-pol2qm74 7981 16 , , , cord-015021-pol2qm74 7981 17 and and CC cord-015021-pol2qm74 7981 18 sepsis sepsis NN cord-015021-pol2qm74 7981 19 related relate VBN cord-015021-pol2qm74 7981 20 parameters parameter NNS cord-015021-pol2qm74 7981 21 . . . cord-015021-pol2qm74 7982 1 It -PRON- PRP cord-015021-pol2qm74 7982 2 was be VBD cord-015021-pol2qm74 7982 3 certified certify VBN cord-015021-pol2qm74 7982 4 that that DT cord-015021-pol2qm74 7982 5 reduction reduction NN cord-015021-pol2qm74 7982 6 of of IN cord-015021-pol2qm74 7982 7 plasma plasma NN cord-015021-pol2qm74 7982 8 endotoxin endotoxin NN cord-015021-pol2qm74 7982 9 was be VBD cord-015021-pol2qm74 7982 10 effective effective JJ cord-015021-pol2qm74 7982 11 in in IN cord-015021-pol2qm74 7982 12 severe severe JJ cord-015021-pol2qm74 7982 13 endotoxemia endotoxemia NN cord-015021-pol2qm74 7982 14 . . . cord-015021-pol2qm74 7983 1 A. A. NNP cord-015021-pol2qm74 7983 2 Lechleuthner Lechleuthner NNP cord-015021-pol2qm74 7983 3 , , , cord-015021-pol2qm74 7983 4 S. S. NNP cord-015021-pol2qm74 7983 5 Aymaz Aymaz NNP cord-015021-pol2qm74 7983 6 , , , cord-015021-pol2qm74 7983 7 G. G. NNP cord-015021-pol2qm74 7983 8 Grass Grass NNP cord-015021-pol2qm74 7983 9 , , , cord-015021-pol2qm74 7983 10 C. C. NNP cord-015021-pol2qm74 7983 11 Stosch Stosch NNP cord-015021-pol2qm74 7983 12 , , , cord-015021-pol2qm74 7983 13 S. S. NNP cord-015021-pol2qm74 7983 14 Dimmeler Dimmeler NNP cord-015021-pol2qm74 7983 15 , , , cord-015021-pol2qm74 7983 16 M. M. NNP cord-015021-pol2qm74 7983 17 Nagelschmidt Nagelschmidt NNP cord-015021-pol2qm74 7983 18 , , , cord-015021-pol2qm74 7983 19 E. E. NNP cord-015021-pol2qm74 7983 20 Neugebauer Neugebauer NNP cord-015021-pol2qm74 7983 21 . . . cord-015021-pol2qm74 7984 1 II II NNP cord-015021-pol2qm74 7984 2 . . . cord-015021-pol2qm74 7985 1 Dept Dept NNP cord-015021-pol2qm74 7985 2 . . . cord-015021-pol2qm74 7986 1 Surgery surgery NN cord-015021-pol2qm74 7986 2 , , , cord-015021-pol2qm74 7986 3 University University NNP cord-015021-pol2qm74 7986 4 of of IN cord-015021-pol2qm74 7986 5 Cologne Cologne NNP cord-015021-pol2qm74 7986 6 , , , cord-015021-pol2qm74 7986 7 Germany Germany NNP cord-015021-pol2qm74 7986 8 . . . cord-015021-pol2qm74 7987 1 Introduction introduction NN cord-015021-pol2qm74 7987 2 : : : cord-015021-pol2qm74 7988 1 The the DT cord-015021-pol2qm74 7988 2 cardiovascular cardiovascular JJ cord-015021-pol2qm74 7988 3 therapy therapy NN cord-015021-pol2qm74 7988 4 of of IN cord-015021-pol2qm74 7988 5 hypodynarnic hypodynarnic NNP cord-015021-pol2qm74 7988 6 shock shock NN cord-015021-pol2qm74 7988 7 states state NNS cord-015021-pol2qm74 7988 8 is be VBZ cord-015021-pol2qm74 7988 9 a a DT cord-015021-pol2qm74 7988 10 challenging challenging JJ cord-015021-pol2qm74 7988 11 problem problem NN cord-015021-pol2qm74 7988 12 . . . cord-015021-pol2qm74 7989 1 In in IN cord-015021-pol2qm74 7989 2 clinical clinical JJ cord-015021-pol2qm74 7989 3 as as RB cord-015021-pol2qm74 7989 4 well well RB cord-015021-pol2qm74 7989 5 as as IN cord-015021-pol2qm74 7989 6 experimental experimental JJ cord-015021-pol2qm74 7989 7 studies study NNS cord-015021-pol2qm74 7989 8 beneficial beneficial JJ cord-015021-pol2qm74 7989 9 functions function NNS cord-015021-pol2qm74 7989 10 of of IN cord-015021-pol2qm74 7989 11 a a DT cord-015021-pol2qm74 7989 12 new new JJ cord-015021-pol2qm74 7989 13 Hg hg NN cord-015021-pol2qm74 7989 14 - - HYPH cord-015021-pol2qm74 7989 15 agonist agonist NN cord-015021-pol2qm74 7989 16 BU BU NNP cord-015021-pol2qm74 7989 17 - - HYPH cord-015021-pol2qm74 7989 18 E-75 E-75 NNP cord-015021-pol2qm74 7989 19 in in IN cord-015021-pol2qm74 7989 20 congestive congestive JJ cord-015021-pol2qm74 7989 21 heart heart NN cord-015021-pol2qm74 7989 22 failure failure NN cord-015021-pol2qm74 7989 23 has have VBZ cord-015021-pol2qm74 7989 24 been be VBN cord-015021-pol2qm74 7989 25 demonstrated demonstrate VBN cord-015021-pol2qm74 7989 26 03aumann 03aumann CD cord-015021-pol2qm74 7989 27 , , , cord-015021-pol2qm74 7989 28 1989 1989 CD cord-015021-pol2qm74 7989 29 ) ) -RRB- cord-015021-pol2qm74 7989 30 . . . cord-015021-pol2qm74 7990 1 Therefore therefore RB cord-015021-pol2qm74 7990 2 , , , cord-015021-pol2qm74 7990 3 we -PRON- PRP cord-015021-pol2qm74 7990 4 investigated investigate VBD cord-015021-pol2qm74 7990 5 the the DT cord-015021-pol2qm74 7990 6 effect effect NN cord-015021-pol2qm74 7990 7 of of IN cord-015021-pol2qm74 7990 8 BU BU NNP cord-015021-pol2qm74 7990 9 - - HYPH cord-015021-pol2qm74 7990 10 E-75 E-75 NNP cord-015021-pol2qm74 7990 11 in in IN cord-015021-pol2qm74 7990 12 hypodynamic hypodynamic JJ cord-015021-pol2qm74 7990 13 shock shock NN cord-015021-pol2qm74 7990 14 in in IN cord-015021-pol2qm74 7990 15 pigs pig NNS cord-015021-pol2qm74 7990 16 . . . cord-015021-pol2qm74 7991 1 Materials material NNS cord-015021-pol2qm74 7991 2 and and CC cord-015021-pol2qm74 7991 3 Methods method NNS cord-015021-pol2qm74 7991 4 : : : cord-015021-pol2qm74 7991 5 Pigs pig NNS cord-015021-pol2qm74 7991 6 ( ( -LRB- cord-015021-pol2qm74 7991 7 Deutsches Deutsches NNP cord-015021-pol2qm74 7991 8 Hausschwein Hausschwein NNP cord-015021-pol2qm74 7991 9 , , , cord-015021-pol2qm74 7991 10 Pitrain Pitrain NNP cord-015021-pol2qm74 7991 11 , , , cord-015021-pol2qm74 7991 12 [ [ -LRB- cord-015021-pol2qm74 7991 13 20 20 CD cord-015021-pol2qm74 7991 14 ] ] -RRB- cord-015021-pol2qm74 7991 15 [ [ -LRB- cord-015021-pol2qm74 7991 16 21 21 CD cord-015021-pol2qm74 7991 17 ] ] -RRB- cord-015021-pol2qm74 7991 18 [ [ -LRB- cord-015021-pol2qm74 7991 19 22 22 CD cord-015021-pol2qm74 7991 20 ] ] -RRB- cord-015021-pol2qm74 7991 21 [ [ -LRB- cord-015021-pol2qm74 7991 22 23 23 CD cord-015021-pol2qm74 7991 23 ] ] -RRB- cord-015021-pol2qm74 7991 24 [ [ -LRB- cord-015021-pol2qm74 7991 25 24 24 CD cord-015021-pol2qm74 7991 26 ] ] -RRB- cord-015021-pol2qm74 7991 27 [ [ -LRB- cord-015021-pol2qm74 7991 28 25 25 CD cord-015021-pol2qm74 7991 29 ] ] -RRB- cord-015021-pol2qm74 7991 30 were be VBD cord-015021-pol2qm74 7991 31 anesthesized anesthesize VBN cord-015021-pol2qm74 7991 32 with with IN cord-015021-pol2qm74 7991 33 Fentanyl Fentanyl NNP cord-015021-pol2qm74 7991 34 / / SYM cord-015021-pol2qm74 7991 35 Dormicum Dormicum NNP cord-015021-pol2qm74 7991 36 , , , cord-015021-pol2qm74 7991 37 ventilated ventilate VBN cord-015021-pol2qm74 7992 1 ( ( -LRB- cord-015021-pol2qm74 7992 2 N20 N20 NNP cord-015021-pol2qm74 7992 3 : : : cord-015021-pol2qm74 7992 4 O o NN cord-015021-pol2qm74 7992 5 2 2 CD cord-015021-pol2qm74 7992 6 = = SYM cord-015021-pol2qm74 7992 7 2:1 2:1 CD cord-015021-pol2qm74 7992 8 ) ) -RRB- cord-015021-pol2qm74 7992 9 and and CC cord-015021-pol2qm74 7992 10 cardiovascular cardiovascular JJ cord-015021-pol2qm74 7992 11 parameters parameter NNS cord-015021-pol2qm74 7992 12 were be VBD cord-015021-pol2qm74 7992 13 monitored monitor VBN cord-015021-pol2qm74 7992 14 with with IN cord-015021-pol2qm74 7992 15 a a DT cord-015021-pol2qm74 7992 16 complete complete JJ cord-015021-pol2qm74 7992 17 ICU ICU NNP cord-015021-pol2qm74 7992 18 - - HYPH cord-015021-pol2qm74 7992 19 eqnipment eqnipment NN cord-015021-pol2qm74 7992 20 . . . cord-015021-pol2qm74 7993 1 The the DT cord-015021-pol2qm74 7993 2 hypodynamic hypodynamic NN cord-015021-pol2qm74 7993 3 model model NN cord-015021-pol2qm74 7993 4 was be VBD cord-015021-pol2qm74 7993 5 established establish VBN cord-015021-pol2qm74 7993 6 in in IN cord-015021-pol2qm74 7993 7 a a DT cord-015021-pol2qm74 7993 8 pilot pilot NN cord-015021-pol2qm74 7993 9 study study NN cord-015021-pol2qm74 7993 10 ( ( -LRB- cord-015021-pol2qm74 7993 11 4 4 CD cord-015021-pol2qm74 7993 12 animals animal NNS cord-015021-pol2qm74 7993 13 ) ) -RRB- cord-015021-pol2qm74 7993 14 to to TO cord-015021-pol2qm74 7993 15 evaluate evaluate VB cord-015021-pol2qm74 7993 16 the the DT cord-015021-pol2qm74 7993 17 effective effective JJ cord-015021-pol2qm74 7993 18 concentration concentration NN cord-015021-pol2qm74 7993 19 of of IN cord-015021-pol2qm74 7993 20 BUE-75 BUE-75 NNP cord-015021-pol2qm74 7994 1 in in IN cord-015021-pol2qm74 7994 2 healthy healthy JJ cord-015021-pol2qm74 7994 3 and and CC cord-015021-pol2qm74 7994 4 endotoxin endotoxin NN cord-015021-pol2qm74 7994 5 ( ( -LRB- cord-015021-pol2qm74 7994 6 LPS)-treated lps)-treate VBN cord-015021-pol2qm74 7994 7 animals animal NNS cord-015021-pol2qm74 7994 8 . . . cord-015021-pol2qm74 7995 1 Endotoxic endotoxic JJ cord-015021-pol2qm74 7995 2 shock shock NN cord-015021-pol2qm74 7995 3 was be VBD cord-015021-pol2qm74 7995 4 induced induce VBN cord-015021-pol2qm74 7995 5 by by IN cord-015021-pol2qm74 7995 6 continous continous JJ cord-015021-pol2qm74 7995 7 infusion infusion NN cord-015021-pol2qm74 7995 8 of of IN cord-015021-pol2qm74 7995 9 10 10 CD cord-015021-pol2qm74 7996 1 ~g ~g NNP cord-015021-pol2qm74 7996 2 LPS LPS NNP cord-015021-pol2qm74 7996 3 / / SYM cord-015021-pol2qm74 7996 4 kgKG kgKG NNP cord-015021-pol2qm74 7996 5 / / SYM cord-015021-pol2qm74 7996 6 h h NN cord-015021-pol2qm74 7996 7 ( ( -LRB- cord-015021-pol2qm74 7996 8 055 055 CD cord-015021-pol2qm74 7996 9 : : : cord-015021-pol2qm74 7996 10 B5 b5 NN cord-015021-pol2qm74 7996 11 , , , cord-015021-pol2qm74 7996 12 Fa Fa NNP cord-015021-pol2qm74 7996 13 . . . cord-015021-pol2qm74 7997 1 Difco Difco NNP cord-015021-pol2qm74 7997 2 ) ) -RRB- cord-015021-pol2qm74 7997 3 . . . cord-015021-pol2qm74 7998 1 The the DT cord-015021-pol2qm74 7998 2 hypodynamic hypodynamic NNP cord-015021-pol2qm74 7998 3 state state NN cord-015021-pol2qm74 7998 4 was be VBD cord-015021-pol2qm74 7998 5 defined define VBN cord-015021-pol2qm74 7998 6 as as IN cord-015021-pol2qm74 7998 7 a a DT cord-015021-pol2qm74 7998 8 decrease decrease NN cord-015021-pol2qm74 7998 9 of of IN cord-015021-pol2qm74 7998 10 cardiac cardiac JJ cord-015021-pol2qm74 7998 11 output output NN cord-015021-pol2qm74 7998 12 by by IN cord-015021-pol2qm74 7998 13 30 30 CD cord-015021-pol2qm74 7998 14 % % NN cord-015021-pol2qm74 7998 15 of of IN cord-015021-pol2qm74 7998 16 steady steady JJ cord-015021-pol2qm74 7998 17 state state NN cord-015021-pol2qm74 7998 18 levels level NNS cord-015021-pol2qm74 7998 19 . . . cord-015021-pol2qm74 7999 1 A a DT cord-015021-pol2qm74 7999 2 wedge wedge NN cord-015021-pol2qm74 7999 3 pressure pressure NN cord-015021-pol2qm74 7999 4 of of IN cord-015021-pol2qm74 7999 5 10 10 CD cord-015021-pol2qm74 7999 6 - - SYM cord-015021-pol2qm74 7999 7 12 12 CD cord-015021-pol2qm74 7999 8 mmHg mmHg NNS cord-015021-pol2qm74 7999 9 was be VBD cord-015021-pol2qm74 7999 10 kept keep VBN cord-015021-pol2qm74 7999 11 constant constant JJ cord-015021-pol2qm74 7999 12 by by IN cord-015021-pol2qm74 7999 13 volume volume NN cord-015021-pol2qm74 7999 14 resucitation resucitation NN cord-015021-pol2qm74 7999 15 during during IN cord-015021-pol2qm74 7999 16 the the DT cord-015021-pol2qm74 7999 17 experiment experiment NN cord-015021-pol2qm74 7999 18 . . . cord-015021-pol2qm74 8000 1 In in IN cord-015021-pol2qm74 8000 2 a a DT cord-015021-pol2qm74 8000 3 subsequent subsequent JJ cord-015021-pol2qm74 8000 4 randomized randomize VBN cord-015021-pol2qm74 8000 5 controlled control VBN cord-015021-pol2qm74 8000 6 trial trial NN cord-015021-pol2qm74 8000 7 ( ( -LRB- cord-015021-pol2qm74 8000 8 RTC RTC NNP cord-015021-pol2qm74 8000 9 ) ) -RRB- cord-015021-pol2qm74 8000 10 3 3 CD cord-015021-pol2qm74 8000 11 groups group NNS cord-015021-pol2qm74 8000 12 with with IN cord-015021-pol2qm74 8000 13 6 6 CD cord-015021-pol2qm74 8000 14 animals animal NNS cord-015021-pol2qm74 8000 15 per per IN cord-015021-pol2qm74 8000 16 group group NN cord-015021-pol2qm74 8000 17 were be VBD cord-015021-pol2qm74 8000 18 studied study VBN cord-015021-pol2qm74 8000 19 . . . cord-015021-pol2qm74 8001 1 The the DT cord-015021-pol2qm74 8001 2 groups group NNS cord-015021-pol2qm74 8001 3 were be VBD cord-015021-pol2qm74 8001 4 treated treat VBN cord-015021-pol2qm74 8001 5 as as IN cord-015021-pol2qm74 8001 6 follows follow VBZ cord-015021-pol2qm74 8001 7 : : : cord-015021-pol2qm74 8001 8 group group NN cord-015021-pol2qm74 8001 9 I I NNP cord-015021-pol2qm74 8001 10 , , , cord-015021-pol2qm74 8001 11 LPS LPS NNP cord-015021-pol2qm74 8001 12 and and CC cord-015021-pol2qm74 8001 13 0,9 0,9 CD cord-015021-pol2qm74 8001 14 % % NN cord-015021-pol2qm74 8001 15 NaC1 nac1 NN cord-015021-pol2qm74 8001 16 ; ; : cord-015021-pol2qm74 8001 17 group group NN cord-015021-pol2qm74 8001 18 II II NNP cord-015021-pol2qm74 8001 19 , , , cord-015021-pol2qm74 8001 20 LPS LPS NNP cord-015021-pol2qm74 8001 21 and and CC cord-015021-pol2qm74 8001 22 BU BU NNP cord-015021-pol2qm74 8001 23 - - HYPH cord-015021-pol2qm74 8001 24 E-75 E-75 NNP cord-015021-pol2qm74 8001 25 ( ( -LRB- cord-015021-pol2qm74 8001 26 100 100 CD cord-015021-pol2qm74 8001 27 # # NN cord-015021-pol2qm74 8001 28 g g NN cord-015021-pol2qm74 8001 29 / / SYM cord-015021-pol2qm74 8001 30 kgKG kgKG NNP cord-015021-pol2qm74 8001 31 / / SYM cord-015021-pol2qm74 8001 32 h h NN cord-015021-pol2qm74 8001 33 ) ) -RRB- cord-015021-pol2qm74 8001 34 ; ; : cord-015021-pol2qm74 8001 35 group group NN cord-015021-pol2qm74 8001 36 III III NNP cord-015021-pol2qm74 8001 37 , , , cord-015021-pol2qm74 8001 38 Famotidine Famotidine NNP cord-015021-pol2qm74 8001 39 ( ( -LRB- cord-015021-pol2qm74 8001 40 H2-blocker H2-blocker NNP cord-015021-pol2qm74 8001 41 ) ) -RRB- cord-015021-pol2qm74 8001 42 pretreatment pretreatment NN cord-015021-pol2qm74 8001 43 ( ( -LRB- cord-015021-pol2qm74 8001 44 1 1 CD cord-015021-pol2qm74 8001 45 mg mg NNP cord-015021-pol2qm74 8001 46 / / SYM cord-015021-pol2qm74 8001 47 kgKG kgKG NNP cord-015021-pol2qm74 8001 48 ) ) -RRB- cord-015021-pol2qm74 8001 49 , , , cord-015021-pol2qm74 8001 50 LPS LPS NNP cord-015021-pol2qm74 8001 51 and and CC cord-015021-pol2qm74 8001 52 BU BU NNP cord-015021-pol2qm74 8001 53 - - HYPH cord-015021-pol2qm74 8001 54 E-75 E-75 NNP cord-015021-pol2qm74 8001 55 . . . cord-015021-pol2qm74 8002 1 Results result NNS cord-015021-pol2qm74 8002 2 : : : cord-015021-pol2qm74 8003 1 The the DT cord-015021-pol2qm74 8003 2 pilot pilot NN cord-015021-pol2qm74 8003 3 study study NN cord-015021-pol2qm74 8003 4 in in IN cord-015021-pol2qm74 8003 5 healthy healthy JJ cord-015021-pol2qm74 8003 6 pigs pig NNS cord-015021-pol2qm74 8003 7 revealed reveal VBN cord-015021-pol2qm74 8003 8 , , , cord-015021-pol2qm74 8003 9 that that IN cord-015021-pol2qm74 8003 10 BU BU NNP cord-015021-pol2qm74 8003 11 - - HYPH cord-015021-pol2qm74 8003 12 E-75 E-75 NNP cord-015021-pol2qm74 8003 13 had have VBD cord-015021-pol2qm74 8003 14 positive positive JJ cord-015021-pol2qm74 8003 15 inotropic inotropic JJ cord-015021-pol2qm74 8003 16 effects effect NNS cord-015021-pol2qm74 8003 17 . . . cord-015021-pol2qm74 8004 1 These these DT cord-015021-pol2qm74 8004 2 effects effect NNS cord-015021-pol2qm74 8004 3 were be VBD cord-015021-pol2qm74 8004 4 inhibited inhibit VBN cord-015021-pol2qm74 8004 5 by by IN cord-015021-pol2qm74 8004 6 the the DT cord-015021-pol2qm74 8004 7 H H NNP cord-015021-pol2qm74 8004 8 2antagonist 2antagonist CD cord-015021-pol2qm74 8004 9 Famotidin Famotidin NNP cord-015021-pol2qm74 8004 10 . . . cord-015021-pol2qm74 8005 1 BU BU NNP cord-015021-pol2qm74 8005 2 - - HYPH cord-015021-pol2qm74 8005 3 E-75 E-75 NNP cord-015021-pol2qm74 8005 4 however however RB cord-015021-pol2qm74 8005 5 had have VBD cord-015021-pol2qm74 8005 6 no no DT cord-015021-pol2qm74 8005 7 beneficial beneficial JJ cord-015021-pol2qm74 8005 8 effects effect NNS cord-015021-pol2qm74 8005 9 in in IN cord-015021-pol2qm74 8005 10 the the DT cord-015021-pol2qm74 8005 11 hypodynamic hypodynamic NNP cord-015021-pol2qm74 8005 12 phase phase NN cord-015021-pol2qm74 8005 13 of of IN cord-015021-pol2qm74 8005 14 endotoxic endotoxic JJ cord-015021-pol2qm74 8005 15 shock shock NN cord-015021-pol2qm74 8005 16 in in IN cord-015021-pol2qm74 8005 17 the the DT cord-015021-pol2qm74 8005 18 RCT RCT NNP cord-015021-pol2qm74 8005 19 . . . cord-015021-pol2qm74 8006 1 Cardiac Cardiac NNP cord-015021-pol2qm74 8006 2 Index Index NNP cord-015021-pol2qm74 8006 3 ( ( -LRB- cord-015021-pol2qm74 8006 4 CI CI NNP cord-015021-pol2qm74 8006 5 ) ) -RRB- cord-015021-pol2qm74 8006 6 and and CC cord-015021-pol2qm74 8006 7 the the DT cord-015021-pol2qm74 8006 8 oxygen oxygen NN cord-015021-pol2qm74 8006 9 delivery delivery NN cord-015021-pol2qm74 8006 10 ( ( -LRB- cord-015021-pol2qm74 8006 11 DO2 DO2 NNP cord-015021-pol2qm74 8006 12 ) ) -RRB- cord-015021-pol2qm74 8006 13 were be VBD cord-015021-pol2qm74 8006 14 not not RB cord-015021-pol2qm74 8006 15 significantly significantly RB cord-015021-pol2qm74 8006 16 influenced influence VBN cord-015021-pol2qm74 8006 17 by by IN cord-015021-pol2qm74 8006 18 BU BU NNP cord-015021-pol2qm74 8006 19 - - HYPH cord-015021-pol2qm74 8006 20 E-75 E-75 NNP cord-015021-pol2qm74 8006 21 application application NN cord-015021-pol2qm74 8006 22 ( ( -LRB- cord-015021-pol2qm74 8006 23 group group NN cord-015021-pol2qm74 8006 24 I -PRON- PRP cord-015021-pol2qm74 8006 25 versus versus IN cord-015021-pol2qm74 8006 26 group group NN cord-015021-pol2qm74 8006 27 II II NNP cord-015021-pol2qm74 8006 28 ) ) -RRB- cord-015021-pol2qm74 8006 29 . . . cord-015021-pol2qm74 8007 1 BU BU NNP cord-015021-pol2qm74 8007 2 - - HYPH cord-015021-pol2qm74 8007 3 E-75 E-75 NNP cord-015021-pol2qm74 8007 4 did do VBD cord-015021-pol2qm74 8007 5 not not RB cord-015021-pol2qm74 8007 6 ameliorate ameliorate VB cord-015021-pol2qm74 8007 7 the the DT cord-015021-pol2qm74 8007 8 negative negative JJ cord-015021-pol2qm74 8007 9 inotropic inotropic JJ cord-015021-pol2qm74 8007 10 effect effect NN cord-015021-pol2qm74 8007 11 measuring measure VBG cord-015021-pol2qm74 8007 12 left leave VBN cord-015021-pol2qm74 8007 13 ventricular ventricular JJ cord-015021-pol2qm74 8007 14 stroke stroke NN cord-015021-pol2qm74 8007 15 work work NN cord-015021-pol2qm74 8007 16 ( ( -LRB- cord-015021-pol2qm74 8007 17 LVSW LVSW NNP cord-015021-pol2qm74 8007 18 ) ) -RRB- cord-015021-pol2qm74 8007 19 in in IN cord-015021-pol2qm74 8007 20 hypodynamic hypodynamic NNP cord-015021-pol2qm74 8007 21 shock shock NN cord-015021-pol2qm74 8007 22 phases phase NNS cord-015021-pol2qm74 8007 23 . . . cord-015021-pol2qm74 8008 1 On on IN cord-015021-pol2qm74 8008 2 the the DT cord-015021-pol2qm74 8008 3 contrary contrary NN cord-015021-pol2qm74 8008 4 , , , cord-015021-pol2qm74 8008 5 BU BU NNP cord-015021-pol2qm74 8008 6 - - HYPH cord-015021-pol2qm74 8008 7 E-75 E-75 NNP cord-015021-pol2qm74 8008 8 led lead VBD cord-015021-pol2qm74 8008 9 to to IN cord-015021-pol2qm74 8008 10 a a DT cord-015021-pol2qm74 8008 11 further further JJ cord-015021-pol2qm74 8008 12 significant significant JJ cord-015021-pol2qm74 8008 13 decrease decrease NN cord-015021-pol2qm74 8008 14 of of IN cord-015021-pol2qm74 8008 15 LVSW LVSW NNP cord-015021-pol2qm74 8008 16 ( ( -LRB- cord-015021-pol2qm74 8008 17 p p NN cord-015021-pol2qm74 8008 18 < < XX cord-015021-pol2qm74 8008 19 0,05 0,05 NNP cord-015021-pol2qm74 8008 20 ) ) -RRB- cord-015021-pol2qm74 8008 21 . . . cord-015021-pol2qm74 8009 1 Famotidin Famotidin NNP cord-015021-pol2qm74 8009 2 pretreatment pretreatment NN cord-015021-pol2qm74 8009 3 did do VBD cord-015021-pol2qm74 8009 4 not not RB cord-015021-pol2qm74 8009 5 affect affect VB cord-015021-pol2qm74 8009 6 the the DT cord-015021-pol2qm74 8009 7 response response NN cord-015021-pol2qm74 8009 8 ( ( -LRB- cord-015021-pol2qm74 8009 9 group group NN cord-015021-pol2qm74 8009 10 III III NNP cord-015021-pol2qm74 8009 11 versus versus IN cord-015021-pol2qm74 8009 12 group group NN cord-015021-pol2qm74 8009 13 II II NNP cord-015021-pol2qm74 8009 14 ) ) -RRB- cord-015021-pol2qm74 8009 15 . . . cord-015021-pol2qm74 8010 1 Conclusion conclusion NN cord-015021-pol2qm74 8010 2 : : : cord-015021-pol2qm74 8011 1 In in IN cord-015021-pol2qm74 8011 2 hypodynamic hypodynamic NNP cord-015021-pol2qm74 8011 3 shock shock NN cord-015021-pol2qm74 8011 4 states state VBZ cord-015021-pol2qm74 8011 5 the the DT cord-015021-pol2qm74 8011 6 H2-agonism h2-agonism NN cord-015021-pol2qm74 8011 7 seemed seem VBD cord-015021-pol2qm74 8011 8 to to TO cord-015021-pol2qm74 8011 9 have have VB cord-015021-pol2qm74 8011 10 no no DT cord-015021-pol2qm74 8011 11 beneficial beneficial JJ cord-015021-pol2qm74 8011 12 effect effect NN cord-015021-pol2qm74 8011 13 under under IN cord-015021-pol2qm74 8011 14 these these DT cord-015021-pol2qm74 8011 15 experimental experimental JJ cord-015021-pol2qm74 8011 16 conditions condition NNS cord-015021-pol2qm74 8011 17 . . . cord-015021-pol2qm74 8012 1 Receptor receptor NN cord-015021-pol2qm74 8012 2 down down IN cord-015021-pol2qm74 8012 3 regulation regulation NN cord-015021-pol2qm74 8012 4 or or CC cord-015021-pol2qm74 8012 5 changes change NNS cord-015021-pol2qm74 8012 6 of of IN cord-015021-pol2qm74 8012 7 signal signal NN cord-015021-pol2qm74 8012 8 transduction transduction NN cord-015021-pol2qm74 8012 9 under under IN cord-015021-pol2qm74 8012 10 septic septic JJ cord-015021-pol2qm74 8012 11 conditions condition NNS cord-015021-pol2qm74 8012 12 may may MD cord-015021-pol2qm74 8012 13 be be VB cord-015021-pol2qm74 8012 14 responsible responsible JJ cord-015021-pol2qm74 8012 15 . . . cord-015021-pol2qm74 8013 1 Cellular cellular JJ cord-015021-pol2qm74 8013 2 studies study NNS cord-015021-pol2qm74 8013 3 may may MD cord-015021-pol2qm74 8013 4 help help VB cord-015021-pol2qm74 8013 5 to to TO cord-015021-pol2qm74 8013 6 identify identify VB cord-015021-pol2qm74 8013 7 these these DT cord-015021-pol2qm74 8013 8 mechanisms mechanism NNS cord-015021-pol2qm74 8013 9 . . . cord-015021-pol2qm74 8014 1 Objectives objective NNS cord-015021-pol2qm74 8014 2 . . . cord-015021-pol2qm74 8015 1 Antithrombin Antithrombin NNP cord-015021-pol2qm74 8015 2 III iii CD cord-015021-pol2qm74 8015 3 inactivation inactivation NN cord-015021-pol2qm74 8015 4 of of IN cord-015021-pol2qm74 8015 5 proccagulant proccagulant JJ cord-015021-pol2qm74 8015 6 proteases protease NNS cord-015021-pol2qm74 8015 7 is be VBZ cord-015021-pol2qm74 8015 8 so so RB cord-015021-pol2qm74 8015 9 far far RB cord-015021-pol2qm74 8015 10 the the DT cord-015021-pol2qm74 8015 11 only only JJ cord-015021-pol2qm74 8015 12 inhibitory inhibitory JJ cord-015021-pol2qm74 8015 13 therapeutic therapeutic JJ cord-015021-pol2qm74 8015 14 approach approach NN cord-015021-pol2qm74 8015 15 to to IN cord-015021-pol2qm74 8015 16 disseminated disseminate VBN cord-015021-pol2qm74 8015 17 intravascutar intravascutar NNP cord-015021-pol2qm74 8015 18 coagulation coagulation NN cord-015021-pol2qm74 8015 19 ( ( -LRB- cord-015021-pol2qm74 8015 20 DIC DIC NNP cord-015021-pol2qm74 8015 21 ) ) -RRB- cord-015021-pol2qm74 8015 22 . . . cord-015021-pol2qm74 8016 1 We -PRON- PRP cord-015021-pol2qm74 8016 2 therefore therefore RB cord-015021-pol2qm74 8016 3 set set VBD cord-015021-pol2qm74 8016 4 out out RP cord-015021-pol2qm74 8016 5 to to TO cord-015021-pol2qm74 8016 6 investigate investigate VB cord-015021-pol2qm74 8016 7 whether whether IN cord-015021-pol2qm74 8016 8 Cll Cll NNP cord-015021-pol2qm74 8016 9 substitution substitution NN cord-015021-pol2qm74 8016 10 reduces reduce VBZ cord-015021-pol2qm74 8016 11 coagulation coagulation NN cord-015021-pol2qm74 8016 12 activation activation NN cord-015021-pol2qm74 8016 13 in in IN cord-015021-pol2qm74 8016 14 an an DT cord-015021-pol2qm74 8016 15 endotoxin endotoxin NN cord-015021-pol2qm74 8016 16 induced induce VBN cord-015021-pol2qm74 8016 17 rabbit rabbit NN cord-015021-pol2qm74 8016 18 DIC DIC NNP cord-015021-pol2qm74 8016 19 model model NN cord-015021-pol2qm74 8016 20 . . . cord-015021-pol2qm74 8017 1 Materials material NNS cord-015021-pol2qm74 8017 2 and and CC cord-015021-pol2qm74 8017 3 Methods method NNS cord-015021-pol2qm74 8017 4 . . . cord-015021-pol2qm74 8018 1 29 29 CD cord-015021-pol2qm74 8018 2 male male JJ cord-015021-pol2qm74 8018 3 rabbits rabbit NNS cord-015021-pol2qm74 8018 4 Chbb Chbb NNP cord-015021-pol2qm74 8018 5 : : : cord-015021-pol2qm74 8018 6 HM(SPF HM(SPF NNP cord-015021-pol2qm74 8018 7 ) ) -RRB- cord-015021-pol2qm74 8018 8 were be VBD cord-015021-pol2qm74 8018 9 randomty randomty NN cord-015021-pol2qm74 8018 10 assigned assign VBN cord-015021-pol2qm74 8018 11 to to IN cord-015021-pol2qm74 8018 12 one one CD cord-015021-pol2qm74 8018 13 of of IN cord-015021-pol2qm74 8018 14 the the DT cord-015021-pol2qm74 8018 15 following follow VBG cord-015021-pol2qm74 8018 16 groups group NNS cord-015021-pol2qm74 8018 17 . . . cord-015021-pol2qm74 8019 1 Group group NN cord-015021-pol2qm74 8019 2 K K NNP cord-015021-pol2qm74 8019 3 : : : cord-015021-pol2qm74 8019 4 NaCI NaCI NNP cord-015021-pol2qm74 8019 5 0.9 0.9 CD cord-015021-pol2qm74 8019 6 % % NN cord-015021-pol2qm74 8019 7 ( ( -LRB- cord-015021-pol2qm74 8019 8 control control NN cord-015021-pol2qm74 8019 9 without without IN cord-015021-pol2qm74 8019 10 endotoxin endotoxin NN cord-015021-pol2qm74 8019 11 , , , cord-015021-pol2qm74 8019 12 n=10 n=10 NNP cord-015021-pol2qm74 8019 13 ) ) -RRB- cord-015021-pol2qm74 8019 14 . . . cord-015021-pol2qm74 8020 1 Group group NN cord-015021-pol2qm74 8020 2 E e NN cord-015021-pol2qm74 8020 3 : : : cord-015021-pol2qm74 8020 4 Endotoxin endotoxin NN cord-015021-pol2qm74 8020 5 120 120 CD cord-015021-pol2qm74 8020 6 tJg tJg NNS cord-015021-pol2qm74 8020 7 kg kg NNS cord-015021-pol2qm74 8020 8 " " `` cord-015021-pol2qm74 8020 9 1 1 CD cord-015021-pol2qm74 8020 10 bolus bolus NN cord-015021-pol2qm74 8020 11 i.v i.v NNP cord-015021-pol2qm74 8020 12 . . . cord-015021-pol2qm74 8021 1 + + SYM cord-015021-pol2qm74 8021 2 NaCI NaCI NNP cord-015021-pol2qm74 8021 3 0.9 0.9 CD cord-015021-pol2qm74 8021 4 % % NN cord-015021-pol2qm74 8021 5 ( ( -LRB- cord-015021-pol2qm74 8021 6 control control NN cord-015021-pol2qm74 8021 7 with with IN cord-015021-pol2qm74 8021 8 endotoxin endotoxin NN cord-015021-pol2qm74 8021 9 , , , cord-015021-pol2qm74 8021 10 n=10 n=10 NNP cord-015021-pol2qm74 8021 11 ) ) -RRB- cord-015021-pol2qm74 8021 12 . . . cord-015021-pol2qm74 8022 1 Group group NN cord-015021-pol2qm74 8022 2 C C NNP cord-015021-pol2qm74 8022 3 : : : cord-015021-pol2qm74 8022 4 Endotoxin endotoxin NN cord-015021-pol2qm74 8022 5 120 120 CD cord-015021-pol2qm74 8022 6 pg pg NN cord-015021-pol2qm74 8022 7 kg kg NNP cord-015021-pol2qm74 8022 8 -1 -1 NNP cord-015021-pol2qm74 8022 9 bolus bolus NNP cord-015021-pol2qm74 8022 10 i.v i.v NNP cord-015021-pol2qm74 8022 11 . . . cord-015021-pol2qm74 8023 1 + + CC cord-015021-pol2qm74 8023 2 Cll Cll NNP cord-015021-pol2qm74 8023 3 400 400 CD cord-015021-pol2qm74 8023 4 U U NNP cord-015021-pol2qm74 8023 5 kg kg NN cord-015021-pol2qm74 8023 6 -1 -1 NN cord-015021-pol2qm74 8023 7 bolus bolus NN cord-015021-pol2qm74 8023 8 + + CC cord-015021-pol2qm74 8024 1 400 400 CD cord-015021-pol2qm74 8024 2 U U NNP cord-015021-pol2qm74 8024 3 kg kg NNP cord-015021-pol2qm74 8024 4 " " '' cord-015021-pol2qm74 8024 5 1 1 CD cord-015021-pol2qm74 8024 6 4h 4h CD cord-015021-pol2qm74 8024 7 " " '' cord-015021-pol2qm74 8024 8 ~ ~ NFP cord-015021-pol2qm74 8024 9 i i PRP cord-015021-pol2qm74 8024 10 , , , cord-015021-pol2qm74 8024 11 v v NNP cord-015021-pol2qm74 8024 12 . . . cord-015021-pol2qm74 8025 1 ( ( -LRB- cord-015021-pol2qm74 8025 2 treatment treatment NN cord-015021-pol2qm74 8025 3 group group NN cord-015021-pol2qm74 8025 4 , , , cord-015021-pol2qm74 8025 5 n=9 n=9 NN cord-015021-pol2qm74 8025 6 ) ) -RRB- cord-015021-pol2qm74 8025 7 . . . cord-015021-pol2qm74 8026 1 All all DT cord-015021-pol2qm74 8026 2 animals animal NNS cord-015021-pol2qm74 8026 3 were be VBD cord-015021-pol2qm74 8026 4 anesthetized anesthetize VBN cord-015021-pol2qm74 8026 5 and and CC cord-015021-pol2qm74 8026 6 mechanically mechanically RB cord-015021-pol2qm74 8026 7 ventilated ventilate VBN cord-015021-pol2qm74 8026 8 . . . cord-015021-pol2qm74 8027 1 Blood blood NN cord-015021-pol2qm74 8027 2 samples sample NNS cord-015021-pol2qm74 8027 3 were be VBD cord-015021-pol2qm74 8027 4 drawn draw VBN cord-015021-pol2qm74 8027 5 prior prior RB cord-015021-pol2qm74 8027 6 to to IN cord-015021-pol2qm74 8027 7 endotoxin endotoxin NNP cord-015021-pol2qm74 8027 8 administration administration NNP cord-015021-pol2qm74 8027 9 ( ( -LRB- cord-015021-pol2qm74 8027 10 M1 M1 NNP cord-015021-pol2qm74 8027 11 ) ) -RRB- cord-015021-pol2qm74 8027 12 and and CC cord-015021-pol2qm74 8027 13 after after IN cord-015021-pol2qm74 8027 14 120 120 CD cord-015021-pol2qm74 8027 15 ( ( -LRB- cord-015021-pol2qm74 8027 16 M2 M2 NNP cord-015021-pol2qm74 8027 17 ) ) -RRB- cord-015021-pol2qm74 8027 18 and and CC cord-015021-pol2qm74 8027 19 240 240 CD cord-015021-pol2qm74 8027 20 rain rain NN cord-015021-pol2qm74 8027 21 . . . cord-015021-pol2qm74 8028 1 ( ( -LRB- cord-015021-pol2qm74 8028 2 M3 M3 NNP cord-015021-pol2qm74 8028 3 ) ) -RRB- cord-015021-pol2qm74 8028 4 . . . cord-015021-pol2qm74 8029 1 Thereafter thereafter RB cord-015021-pol2qm74 8029 2 , , , cord-015021-pol2qm74 8029 3 lung lung NN cord-015021-pol2qm74 8029 4 and and CC cord-015021-pol2qm74 8029 5 liver liver NN cord-015021-pol2qm74 8029 6 tissue tissue NN cord-015021-pol2qm74 8029 7 samples sample NNS cord-015021-pol2qm74 8029 8 were be VBD cord-015021-pol2qm74 8029 9 taken take VBN cord-015021-pol2qm74 8029 10 intravitatly intravitatly RB cord-015021-pol2qm74 8029 11 in in IN cord-015021-pol2qm74 8029 12 a a DT cord-015021-pol2qm74 8029 13 standardized standardized JJ cord-015021-pol2qm74 8029 14 fashion fashion NN cord-015021-pol2qm74 8029 15 for for IN cord-015021-pol2qm74 8029 16 H&E H&E NNP cord-015021-pol2qm74 8029 17 microscopic microscopic JJ cord-015021-pol2qm74 8029 18 fibrin fibrin NN cord-015021-pol2qm74 8029 19 quantification quantification NN cord-015021-pol2qm74 8029 20 using use VBG cord-015021-pol2qm74 8029 21 a a DT cord-015021-pol2qm74 8029 22 triple triple JJ cord-015021-pol2qm74 8029 23 score score NN cord-015021-pol2qm74 8029 24 ( ( -LRB- cord-015021-pol2qm74 8029 25 FIBS FIBS NNP cord-015021-pol2qm74 8029 26 ) ) -RRB- cord-015021-pol2qm74 8029 27 . . . cord-015021-pol2qm74 8030 1 From from IN cord-015021-pol2qm74 8030 2 all all DT cord-015021-pol2qm74 8030 3 blood blood NN cord-015021-pol2qm74 8030 4 samples sample NNS cord-015021-pol2qm74 8030 5 the the DT cord-015021-pol2qm74 8030 6 prothrombin prothrombin NN cord-015021-pol2qm74 8030 7 time time NN cord-015021-pol2qm74 8030 8 ( ( -LRB- cord-015021-pol2qm74 8030 9 PT PT NNP cord-015021-pol2qm74 8030 10 ) ) -RRB- cord-015021-pol2qm74 8030 11 , , , cord-015021-pol2qm74 8030 12 activated activate VBD cord-015021-pol2qm74 8030 13 partial partial JJ cord-015021-pol2qm74 8030 14 thromboplastin thromboplastin NNP cord-015021-pol2qm74 8030 15 time time NN cord-015021-pol2qm74 8030 16 ( ( -LRB- cord-015021-pol2qm74 8030 17 aPTT aptt NN cord-015021-pol2qm74 8030 18 ) ) -RRB- cord-015021-pol2qm74 8030 19 , , , cord-015021-pol2qm74 8030 20 fibrin fibrin NN cord-015021-pol2qm74 8030 21 monomers monomer NNS cord-015021-pol2qm74 8030 22 ( ( -LRB- cord-015021-pol2qm74 8030 23 FM FM NNP cord-015021-pol2qm74 8030 24 ) ) -RRB- cord-015021-pol2qm74 8030 25 , , , cord-015021-pol2qm74 8030 26 and and CC cord-015021-pol2qm74 8030 27 d d NNS cord-015021-pol2qm74 8030 28 - - NNS cord-015021-pol2qm74 8030 29 dimers dimer NNS cord-015021-pol2qm74 8030 30 ( ( -LRB- cord-015021-pol2qm74 8030 31 DD DD NNP cord-015021-pol2qm74 8030 32 ) ) -RRB- cord-015021-pol2qm74 8030 33 were be VBD cord-015021-pol2qm74 8030 34 measured measure VBN cord-015021-pol2qm74 8030 35 . . . cord-015021-pol2qm74 8031 1 For for IN cord-015021-pol2qm74 8031 2 statistical statistical JJ cord-015021-pol2qm74 8031 3 significance significance NN cord-015021-pol2qm74 8031 4 of of IN cord-015021-pol2qm74 8031 5 differences difference NNS cord-015021-pol2qm74 8031 6 between between IN cord-015021-pol2qm74 8031 7 the the DT cord-015021-pol2qm74 8031 8 groups group NNS cord-015021-pol2qm74 8031 9 ANOVAs anova NNS cord-015021-pol2qm74 8031 10 and and CC cord-015021-pol2qm74 8031 11 the the DT cord-015021-pol2qm74 8031 12 Wilcoxon Wilcoxon NNP cord-015021-pol2qm74 8031 13 test test NN cord-015021-pol2qm74 8031 14 ( ( -LRB- cord-015021-pol2qm74 8031 15 FIBS FIBS NNP cord-015021-pol2qm74 8031 16 ) ) -RRB- cord-015021-pol2qm74 8031 17 were be VBD cord-015021-pol2qm74 8031 18 performed perform VBN cord-015021-pol2qm74 8031 19 . . . cord-015021-pol2qm74 8032 1 Results result NNS cord-015021-pol2qm74 8032 2 . . . cord-015021-pol2qm74 8033 1 FIBS fib NNS cord-015021-pol2qm74 8033 2 for for IN cord-015021-pol2qm74 8033 3 lung lung NN cord-015021-pol2qm74 8033 4 / / SYM cord-015021-pol2qm74 8033 5 liver liver NN cord-015021-pol2qm74 8033 6 were be VBD cord-015021-pol2qm74 8033 7 significantly significantly RB cord-015021-pol2qm74 8033 8 different different JJ cord-015021-pol2qm74 8033 9 ( ( -LRB- cord-015021-pol2qm74 8033 10 p<0.05 p<0.05 JJ cord-015021-pol2qm74 8033 11 ) ) -RRB- cord-015021-pol2qm74 8033 12 between between IN cord-015021-pol2qm74 8033 13 group group NN cord-015021-pol2qm74 8033 14 E E NNP cord-015021-pol2qm74 8033 15 ( ( -LRB- cord-015021-pol2qm74 8033 16 lung lung NNP cord-015021-pol2qm74 8033 17 180 180 CD cord-015021-pol2qm74 8033 18 , , , cord-015021-pol2qm74 8033 19 liver liver NN cord-015021-pol2qm74 8033 20 159 159 CD cord-015021-pol2qm74 8033 21 ) ) -RRB- cord-015021-pol2qm74 8033 22 and and CC cord-015021-pol2qm74 8033 23 C C NNP cord-015021-pol2qm74 8033 24 ( ( -LRB- cord-015021-pol2qm74 8033 25 lung lung NNP cord-015021-pol2qm74 8033 26 89 89 CD cord-015021-pol2qm74 8033 27 , , , cord-015021-pol2qm74 8033 28 liver liver NN cord-015021-pol2qm74 8033 29 0 0 NFP cord-015021-pol2qm74 8033 30 ) ) -RRB- cord-015021-pol2qm74 8033 31 ( ( -LRB- cord-015021-pol2qm74 8033 32 Group Group NNP cord-015021-pol2qm74 8033 33 K K NNP cord-015021-pol2qm74 8033 34 : : : cord-015021-pol2qm74 8033 35 lung lung NN cord-015021-pol2qm74 8033 36 11 11 CD cord-015021-pol2qm74 8033 37 , , , cord-015021-pol2qm74 8033 38 liver liver NN cord-015021-pol2qm74 8033 39 0 0 CD cord-015021-pol2qm74 8033 40 ) ) -RRB- cord-015021-pol2qm74 8033 41 . . . cord-015021-pol2qm74 8033 42 , , , cord-015021-pol2qm74 8033 43 a a DT cord-015021-pol2qm74 8033 44 synthetic synthetic JJ cord-015021-pol2qm74 8033 45 serine serine NN cord-015021-pol2qm74 8033 46 proteinase proteinase NN cord-015021-pol2qm74 8033 47 inhibitor inhibitor NN cord-015021-pol2qm74 8033 48 , , , cord-015021-pol2qm74 8033 49 has have VBZ cord-015021-pol2qm74 8033 50 an an DT cord-015021-pol2qm74 8033 51 anticoagulant anticoagulant JJ cord-015021-pol2qm74 8033 52 activity activity NN cord-015021-pol2qm74 8033 53 in in IN cord-015021-pol2qm74 8033 54 the the DT cord-015021-pol2qm74 8033 55 absence absence NN cord-015021-pol2qm74 8033 56 of of IN cord-015021-pol2qm74 8033 57 " " `` cord-015021-pol2qm74 8033 58 antithrobim antithrobim NNP cord-015021-pol2qm74 8033 59 III III NNP cord-015021-pol2qm74 8033 60 . . . cord-015021-pol2qm74 8034 1 Gabexate Gabexate NNP cord-015021-pol2qm74 8034 2 has have VBZ cord-015021-pol2qm74 8034 3 been be VBN cord-015021-pol2qm74 8034 4 reported report VBN cord-015021-pol2qm74 8034 5 to to TO cord-015021-pol2qm74 8034 6 be be VB cord-015021-pol2qm74 8034 7 useful useful JJ cord-015021-pol2qm74 8034 8 in in IN cord-015021-pol2qm74 8034 9 the the DT cord-015021-pol2qm74 8034 10 treatment treatment NN cord-015021-pol2qm74 8034 11 of of IN cord-015021-pol2qm74 8034 12 disseminated disseminate VBN cord-015021-pol2qm74 8034 13 intravascular intravascular JJ cord-015021-pol2qm74 8034 14 coaguiation coaguiation NN cord-015021-pol2qm74 8034 15 due due IN cord-015021-pol2qm74 8034 16 to to IN cord-015021-pol2qm74 8034 17 neoplastic neoplastic JJ cord-015021-pol2qm74 8034 18 diseases disease NNS cord-015021-pol2qm74 8034 19 . . . cord-015021-pol2qm74 8035 1 In in IN cord-015021-pol2qm74 8035 2 this this DT cord-015021-pol2qm74 8035 3 study study NN cord-015021-pol2qm74 8035 4 , , , cord-015021-pol2qm74 8035 5 we -PRON- PRP cord-015021-pol2qm74 8035 6 investigated investigate VBD cord-015021-pol2qm74 8035 7 gabexate gabexate NNP cord-015021-pol2qm74 8035 8 therapy therapy NN cord-015021-pol2qm74 8035 9 for for IN cord-015021-pol2qm74 8035 10 the the DT cord-015021-pol2qm74 8035 11 treatment treatment NN cord-015021-pol2qm74 8035 12 of of IN cord-015021-pol2qm74 8035 13 DIC DIC NNP cord-015021-pol2qm74 8035 14 due due IN cord-015021-pol2qm74 8035 15 to to IN cord-015021-pol2qm74 8035 16 sepsis sepsis NN cord-015021-pol2qm74 8035 17 in in IN cord-015021-pol2qm74 8035 18 the the DT cord-015021-pol2qm74 8035 19 postoperative postoperative JJ cord-015021-pol2qm74 8035 20 critical critical JJ cord-015021-pol2qm74 8035 21 patients patient NNS cord-015021-pol2qm74 8035 22 . . . cord-015021-pol2qm74 8036 1 MATERIALS materials NN cord-015021-pol2qm74 8036 2 AND and CC cord-015021-pol2qm74 8036 3 METHODS method NNS cord-015021-pol2qm74 8036 4 : : : cord-015021-pol2qm74 8037 1 From from IN cord-015021-pol2qm74 8037 2 July July NNP cord-015021-pol2qm74 8037 3 1992 1992 CD cord-015021-pol2qm74 8037 4 to to IN cord-015021-pol2qm74 8037 5 June June NNP cord-015021-pol2qm74 8037 6 1993 1993 CD cord-015021-pol2qm74 8037 7 , , , cord-015021-pol2qm74 8037 8 15 15 CD cord-015021-pol2qm74 8037 9 patients patient NNS cord-015021-pol2qm74 8037 10 in in IN cord-015021-pol2qm74 8037 11 the the DT cord-015021-pol2qm74 8037 12 surgical surgical JJ cord-015021-pol2qm74 8037 13 intensive intensive JJ cord-015021-pol2qm74 8037 14 care care NN cord-015021-pol2qm74 8037 15 unit unit NN cord-015021-pol2qm74 8037 16 met meet VBD cord-015021-pol2qm74 8037 17 the the DT cord-015021-pol2qm74 8037 18 criteria criterion NNS cord-015021-pol2qm74 8037 19 of of IN cord-015021-pol2qm74 8037 20 DIC DIC NNP cord-015021-pol2qm74 8037 21 or or CC cord-015021-pol2qm74 8037 22 pre pre JJ cord-015021-pol2qm74 8037 23 - - JJ cord-015021-pol2qm74 8037 24 DIC dic JJ cord-015021-pol2qm74 8037 25 . . . cord-015021-pol2qm74 8038 1 Eleven eleven CD cord-015021-pol2qm74 8038 2 were be VBD cord-015021-pol2qm74 8038 3 male male JJ cord-015021-pol2qm74 8038 4 and and CC cord-015021-pol2qm74 8038 5 four four CD cord-015021-pol2qm74 8038 6 were be VBD cord-015021-pol2qm74 8038 7 female female JJ cord-015021-pol2qm74 8038 8 with with IN cord-015021-pol2qm74 8038 9 the the DT cord-015021-pol2qm74 8038 10 mean mean JJ cord-015021-pol2qm74 8038 11 age age NN cord-015021-pol2qm74 8038 12 of of IN cord-015021-pol2qm74 8038 13 66.7 66.7 CD cord-015021-pol2qm74 8038 14 years year NNS cord-015021-pol2qm74 8038 15 . . . cord-015021-pol2qm74 8039 1 All all PDT cord-015021-pol2qm74 8039 2 these these DT cord-015021-pol2qm74 8039 3 patients patient NNS cord-015021-pol2qm74 8039 4 suffered suffer VBD cord-015021-pol2qm74 8039 5 from from IN cord-015021-pol2qm74 8039 6 some some DT cord-015021-pol2qm74 8039 7 complication complication NN cord-015021-pol2qm74 8039 8 of of IN cord-015021-pol2qm74 8039 9 operations operation NNS cord-015021-pol2qm74 8039 10 which which WDT cord-015021-pol2qm74 8039 11 led lead VBD cord-015021-pol2qm74 8039 12 to to IN cord-015021-pol2qm74 8039 13 the the DT cord-015021-pol2qm74 8039 14 development development NN cord-015021-pol2qm74 8039 15 of of IN cord-015021-pol2qm74 8039 16 sepsis sepsis NN cord-015021-pol2qm74 8039 17 . . . cord-015021-pol2qm74 8040 1 FOY FOY NNP cord-015021-pol2qm74 8040 2 was be VBD cord-015021-pol2qm74 8040 3 administered administer VBN cord-015021-pol2qm74 8040 4 at at IN cord-015021-pol2qm74 8040 5 the the DT cord-015021-pol2qm74 8040 6 rate rate NN cord-015021-pol2qm74 8040 7 of of IN cord-015021-pol2qm74 8041 1 2mg 2mg NNP cord-015021-pol2qm74 8041 2 / / SYM cord-015021-pol2qm74 8041 3 kg kg NN cord-015021-pol2qm74 8041 4 / / SYM cord-015021-pol2qm74 8041 5 hr hr NN cord-015021-pol2qm74 8041 6 untiI untii NN cord-015021-pol2qm74 8042 1 the the DT cord-015021-pol2qm74 8042 2 coagulation coagulation NN cord-015021-pol2qm74 8042 3 profile profile NN cord-015021-pol2qm74 8042 4 retumed retume VBN cord-015021-pol2qm74 8042 5 to to IN cord-015021-pol2qm74 8042 6 normal normal JJ cord-015021-pol2qm74 8042 7 or or CC cord-015021-pol2qm74 8042 8 the the DT cord-015021-pol2qm74 8042 9 patient patient NN cord-015021-pol2qm74 8042 10 died die VBD cord-015021-pol2qm74 8042 11 . . . cord-015021-pol2qm74 8043 1 The the DT cord-015021-pol2qm74 8043 2 coagulation coagulation NN cord-015021-pol2qm74 8043 3 parameters parameter NNS cord-015021-pol2qm74 8043 4 were be VBD cord-015021-pol2qm74 8043 5 monitored monitor VBN cord-015021-pol2qm74 8043 6 before before RB cord-015021-pol2qm74 8043 7 and and CC cord-015021-pol2qm74 8043 8 on on IN cord-015021-pol2qm74 8043 9 the the DT cord-015021-pol2qm74 8043 10 1st 1st NN cord-015021-pol2qm74 8043 11 , , , cord-015021-pol2qm74 8043 12 3rd 3rd JJ cord-015021-pol2qm74 8043 13 , , , cord-015021-pol2qm74 8043 14 5th 5th JJ cord-015021-pol2qm74 8043 15 and and CC cord-015021-pol2qm74 8043 16 7th 7th JJ cord-015021-pol2qm74 8043 17 day day NN cord-015021-pol2qm74 8043 18 . . . cord-015021-pol2qm74 8044 1 RESULTS result NNS cord-015021-pol2qm74 8044 2 : : : cord-015021-pol2qm74 8045 1 Fourteen fourteen CD cord-015021-pol2qm74 8045 2 of of IN cord-015021-pol2qm74 8045 3 these these DT cord-015021-pol2qm74 8045 4 fifteen fifteen CD cord-015021-pol2qm74 8045 5 patients patient NNS cord-015021-pol2qm74 8045 6 died die VBD cord-015021-pol2qm74 8045 7 despite despite IN cord-015021-pol2qm74 8045 8 transient transient JJ cord-015021-pol2qm74 8045 9 improvement improvement NN cord-015021-pol2qm74 8045 10 of of IN cord-015021-pol2qm74 8045 11 the the DT cord-015021-pol2qm74 8045 12 coagulation coagulation NN cord-015021-pol2qm74 8045 13 parameters parameter NNS cord-015021-pol2qm74 8045 14 in in IN cord-015021-pol2qm74 8045 15 five five CD cord-015021-pol2qm74 8045 16 patients patient NNS cord-015021-pol2qm74 8045 17 . . . cord-015021-pol2qm74 8046 1 These these DT cord-015021-pol2qm74 8046 2 patients patient NNS cord-015021-pol2qm74 8046 3 suffered suffer VBD cord-015021-pol2qm74 8046 4 from from IN cord-015021-pol2qm74 8046 5 sepsis sepsis NN cord-015021-pol2qm74 8046 6 resulting result VBG cord-015021-pol2qm74 8046 7 from from IN cord-015021-pol2qm74 8046 8 surgical surgical JJ cord-015021-pol2qm74 8046 9 complications complication NNS cord-015021-pol2qm74 8046 10 which which WDT cord-015021-pol2qm74 8046 11 could could MD cord-015021-pol2qm74 8046 12 not not RB cord-015021-pol2qm74 8046 13 be be VB cord-015021-pol2qm74 8046 14 well well RB cord-015021-pol2qm74 8046 15 controlled control VBN cord-015021-pol2qm74 8046 16 . . . cord-015021-pol2qm74 8047 1 The the DT cord-015021-pol2qm74 8047 2 only only JJ cord-015021-pol2qm74 8047 3 survival survival NN cord-015021-pol2qm74 8047 4 was be VBD cord-015021-pol2qm74 8047 5 a a DT cord-015021-pol2qm74 8047 6 case case NN cord-015021-pol2qm74 8047 7 of of IN cord-015021-pol2qm74 8047 8 recurrent recurrent JJ cord-015021-pol2qm74 8047 9 intrahepatic intrahepatic JJ cord-015021-pol2qm74 8047 10 duct duct NN cord-015021-pol2qm74 8047 11 stone stone NN cord-015021-pol2qm74 8047 12 with with IN cord-015021-pol2qm74 8047 13 biliary biliary JJ cord-015021-pol2qm74 8047 14 tract tract NN cord-015021-pol2qm74 8047 15 infection infection NN cord-015021-pol2qm74 8047 16 complicated complicate VBN cord-015021-pol2qm74 8047 17 with with IN cord-015021-pol2qm74 8047 18 sepsis sepsis NN cord-015021-pol2qm74 8047 19 and and CC cord-015021-pol2qm74 8047 20 DIC DIC NNP cord-015021-pol2qm74 8047 21 . . . cord-015021-pol2qm74 8048 1 After after IN cord-015021-pol2qm74 8048 2 choledocholithotomy choledocholithotomy NN cord-015021-pol2qm74 8048 3 and and CC cord-015021-pol2qm74 8048 4 the the DT cord-015021-pol2qm74 8048 5 use use NN cord-015021-pol2qm74 8048 6 of of IN cord-015021-pol2qm74 8048 7 FOY FOY NNP cord-015021-pol2qm74 8048 8 , , , cord-015021-pol2qm74 8048 9 the the DT cord-015021-pol2qm74 8048 10 patient patient NN cord-015021-pol2qm74 8048 11 recovered recover VBD cord-015021-pol2qm74 8048 12 gradually gradually RB cord-015021-pol2qm74 8048 13 . . . cord-015021-pol2qm74 8049 1 CONCLUSION conclusion NN cord-015021-pol2qm74 8049 2 : : : cord-015021-pol2qm74 8050 1 DIC DIC NNP cord-015021-pol2qm74 8050 2 is be VBZ cord-015021-pol2qm74 8050 3 a a DT cord-015021-pol2qm74 8050 4 late late JJ cord-015021-pol2qm74 8050 5 manifestation manifestation NN cord-015021-pol2qm74 8050 6 of of IN cord-015021-pol2qm74 8050 7 sepsis sepsis NN cord-015021-pol2qm74 8050 8 in in IN cord-015021-pol2qm74 8050 9 the the DT cord-015021-pol2qm74 8050 10 critical critical JJ cord-015021-pol2qm74 8050 11 surgical surgical JJ cord-015021-pol2qm74 8050 12 patients patient NNS cord-015021-pol2qm74 8050 13 . . . cord-015021-pol2qm74 8051 1 The the DT cord-015021-pol2qm74 8051 2 most most RBS cord-015021-pol2qm74 8051 3 important important JJ cord-015021-pol2qm74 8051 4 thing thing NN cord-015021-pol2qm74 8051 5 is be VBZ cord-015021-pol2qm74 8051 6 to to TO cord-015021-pol2qm74 8051 7 eradicate eradicate VB cord-015021-pol2qm74 8051 8 the the DT cord-015021-pol2qm74 8051 9 cause cause NN cord-015021-pol2qm74 8051 10 of of IN cord-015021-pol2qm74 8051 11 sepsis sepsis NN cord-015021-pol2qm74 8051 12 . . . cord-015021-pol2qm74 8052 1 If if IN cord-015021-pol2qm74 8052 2 the the DT cord-015021-pol2qm74 8052 3 underlying underlie VBG cord-015021-pol2qm74 8052 4 septic septic JJ cord-015021-pol2qm74 8052 5 focus focus NN cord-015021-pol2qm74 8052 6 can can MD cord-015021-pol2qm74 8052 7 not not RB cord-015021-pol2qm74 8052 8 be be VB cord-015021-pol2qm74 8052 9 controlled control VBN cord-015021-pol2qm74 8052 10 , , , cord-015021-pol2qm74 8052 11 DIC DIC NNP cord-015021-pol2qm74 8052 12 will will MD cord-015021-pol2qm74 8052 13 persist persist VB cord-015021-pol2qm74 8052 14 despite despite IN cord-015021-pol2qm74 8052 15 the the DT cord-015021-pol2qm74 8052 16 use use NN cord-015021-pol2qm74 8052 17 of of IN cord-015021-pol2qm74 8052 18 gabexate gabexate NNP cord-015021-pol2qm74 8052 19 mesilate mesilate NNP cord-015021-pol2qm74 8052 20 . . . cord-015021-pol2qm74 8053 1 Emergency emergency NN cord-015021-pol2qm74 8053 2 Surgery surgery NN cord-015021-pol2qm74 8053 3 , , , cord-015021-pol2qm74 8053 4 Taipei Taipei NNP cord-015021-pol2qm74 8053 5 Veterans Veterans NNPS cord-015021-pol2qm74 8053 6 General General NNP cord-015021-pol2qm74 8053 7 Hospital Hospital NNP cord-015021-pol2qm74 8053 8 , , , cord-015021-pol2qm74 8053 9 Taipei Taipei NNP cord-015021-pol2qm74 8053 10 , , , cord-015021-pol2qm74 8053 11 Taiwan Taiwan NNP cord-015021-pol2qm74 8053 12 . . . cord-015021-pol2qm74 8054 1 There there EX cord-015021-pol2qm74 8054 2 are be VBP cord-015021-pol2qm74 8054 3 2 2 CD cord-015021-pol2qm74 8054 4 main main JJ cord-015021-pol2qm74 8054 5 types type NNS cord-015021-pol2qm74 8054 6 of of IN cord-015021-pol2qm74 8054 7 bradykinin bradykinin NN cord-015021-pol2qm74 8054 8 ( ( -LRB- cord-015021-pol2qm74 8054 9 BK BK NNP cord-015021-pol2qm74 8054 10 ) ) -RRB- cord-015021-pol2qm74 8054 11 receptor receptor NN cord-015021-pol2qm74 8054 12 , , , cord-015021-pol2qm74 8054 13 namely namely RB cord-015021-pol2qm74 8054 14 BK~ BK~ NNP cord-015021-pol2qm74 8054 15 and and CC cord-015021-pol2qm74 8054 16 BK BK NNP cord-015021-pol2qm74 8054 17 z. z. NNP cord-015021-pol2qm74 8055 1 The the DT cord-015021-pol2qm74 8055 2 BK BK NNP cord-015021-pol2qm74 8055 3 2 2 CD cord-015021-pol2qm74 8055 4 receptor receptor NN cord-015021-pol2qm74 8055 5 is be VBZ cord-015021-pol2qm74 8055 6 constitutive constitutive JJ cord-015021-pol2qm74 8055 7 . . . cord-015021-pol2qm74 8056 1 The the DT cord-015021-pol2qm74 8056 2 BK BK NNP cord-015021-pol2qm74 8056 3 1 1 CD cord-015021-pol2qm74 8056 4 receptor receptor NN cord-015021-pol2qm74 8056 5 is be VBZ cord-015021-pol2qm74 8056 6 also also RB cord-015021-pol2qm74 8056 7 constitutive constitutive JJ cord-015021-pol2qm74 8056 8 but but CC cord-015021-pol2qm74 8056 9 in in IN cord-015021-pol2qm74 8056 10 the the DT cord-015021-pol2qm74 8056 11 majority majority NN cord-015021-pol2qm74 8056 12 of of IN cord-015021-pol2qm74 8056 13 cases case NNS cord-015021-pol2qm74 8056 14 is be VBZ cord-015021-pol2qm74 8056 15 inducible inducible JJ cord-015021-pol2qm74 8056 16 and and CC cord-015021-pol2qm74 8056 17 involved involve VBN cord-015021-pol2qm74 8056 18 in in IN cord-015021-pol2qm74 8056 19 chronic chronic JJ cord-015021-pol2qm74 8056 20 inflammatory inflammatory JJ cord-015021-pol2qm74 8056 21 syndromes syndrome NNS cord-015021-pol2qm74 8056 22 such such JJ cord-015021-pol2qm74 8056 23 as as IN cord-015021-pol2qm74 8056 24 sepsis sepsis NN cord-015021-pol2qm74 8056 25 , , , cord-015021-pol2qm74 8056 26 hyperalgesia hyperalgesia NN cord-015021-pol2qm74 8056 27 and and CC cord-015021-pol2qm74 8056 28 airways airways NNP cord-015021-pol2qm74 8056 29 hyperreactivty hyperreactivty NNP cord-015021-pol2qm74 8056 30 in in IN cord-015021-pol2qm74 8056 31 animals animal NNS cord-015021-pol2qm74 8056 32 . . . cord-015021-pol2qm74 8057 1 The the DT cord-015021-pol2qm74 8057 2 mechanism(s mechanism(s NNP cord-015021-pol2qm74 8057 3 ) ) -RRB- cord-015021-pol2qm74 8057 4 involved involve VBN cord-015021-pol2qm74 8057 5 in in IN cord-015021-pol2qm74 8057 6 the the DT cord-015021-pol2qm74 8057 7 upregulation upregulation NN cord-015021-pol2qm74 8057 8 of of IN cord-015021-pol2qm74 8057 9 the the DT cord-015021-pol2qm74 8057 10 BK BK NNP cord-015021-pol2qm74 8057 11 1 1 CD cord-015021-pol2qm74 8057 12 receptor receptor NN cord-015021-pol2qm74 8057 13 is be VBZ cord-015021-pol2qm74 8057 14 unclear unclear JJ cord-015021-pol2qm74 8057 15 , , , cord-015021-pol2qm74 8057 16 however however RB cord-015021-pol2qm74 8057 17 a a DT cord-015021-pol2qm74 8057 18 variety variety NN cord-015021-pol2qm74 8057 19 of of IN cord-015021-pol2qm74 8057 20 agents agent NNS cord-015021-pol2qm74 8057 21 including include VBG cord-015021-pol2qm74 8057 22 LPS LPS NNP cord-015021-pol2qm74 8057 23 , , , cord-015021-pol2qm74 8057 24 E E NNP cord-015021-pol2qm74 8057 25 Coil Coil NNP cord-015021-pol2qm74 8057 26 and and CC cord-015021-pol2qm74 8057 27 ILl ILl NNS cord-015021-pol2qm74 8057 28 are be VBP cord-015021-pol2qm74 8057 29 particularly particularly RB cord-015021-pol2qm74 8057 30 efficacious efficacious JJ cord-015021-pol2qm74 8057 31 in in IN cord-015021-pol2qm74 8057 32 vitro vitro FW cord-015021-pol2qm74 8057 33 and and CC cord-015021-pol2qm74 8057 34 in in IN cord-015021-pol2qm74 8057 35 vivo vivo NNP cord-015021-pol2qm74 8057 36 . . . cord-015021-pol2qm74 8058 1 ILl ILl NNP cord-015021-pol2qm74 8058 2 and and CC cord-015021-pol2qm74 8058 3 Bradykinin Bradykinin NNP cord-015021-pol2qm74 8058 4 acting act VBG cord-015021-pol2qm74 8058 5 at at IN cord-015021-pol2qm74 8058 6 their -PRON- PRP$ cord-015021-pol2qm74 8058 7 respective respective JJ cord-015021-pol2qm74 8058 8 receptors receptor NNS cord-015021-pol2qm74 8058 9 are be VBP cord-015021-pol2qm74 8058 10 believed believe VBN cord-015021-pol2qm74 8058 11 to to TO cord-015021-pol2qm74 8058 12 be be VB cord-015021-pol2qm74 8058 13 involved involve VBN cord-015021-pol2qm74 8058 14 in in IN cord-015021-pol2qm74 8058 15 SIRS SIRS NNP cord-015021-pol2qm74 8058 16 / / SYM cord-015021-pol2qm74 8058 17 Sepsis sepsis NN cord-015021-pol2qm74 8058 18 . . . cord-015021-pol2qm74 8059 1 We -PRON- PRP cord-015021-pol2qm74 8059 2 have have VBP cord-015021-pol2qm74 8059 3 investigated investigate VBN cord-015021-pol2qm74 8059 4 the the DT cord-015021-pol2qm74 8059 5 effect effect NN cord-015021-pol2qm74 8059 6 of of IN cord-015021-pol2qm74 8059 7 antagonists antagonist NNS cord-015021-pol2qm74 8059 8 at at IN cord-015021-pol2qm74 8059 9 ILl ILl NNP cord-015021-pol2qm74 8059 10 ( ( -LRB- cord-015021-pol2qm74 8059 11 Antril Antril NNP cord-015021-pol2qm74 8059 12 ) ) -RRB- cord-015021-pol2qm74 8059 13 , , , cord-015021-pol2qm74 8059 14 BK BK NNP cord-015021-pol2qm74 8059 15 2 2 CD cord-015021-pol2qm74 8059 16 ( ( -LRB- cord-015021-pol2qm74 8059 17 Bradycor Bradycor NNP cord-015021-pol2qm74 8059 18 [ [ -LRB- cord-015021-pol2qm74 8059 19 CP-0127]),BK~ CP-0127]),BK~ NNP cord-015021-pol2qm74 8059 20 ( ( -LRB- cord-015021-pol2qm74 8059 21 CP-0298 CP-0298 NNS cord-015021-pol2qm74 8059 22 ) ) -RRB- cord-015021-pol2qm74 8059 23 and and CC cord-015021-pol2qm74 8059 24 BKz BKz NNP cord-015021-pol2qm74 8059 25 / / SYM cord-015021-pol2qm74 8059 26 BK BK NNP cord-015021-pol2qm74 8059 27 1 1 CD cord-015021-pol2qm74 8059 28 ( ( -LRB- cord-015021-pol2qm74 8059 29 CP-0364 CP-0364 NNP cord-015021-pol2qm74 8059 30 ) ) -RRB- cord-015021-pol2qm74 8059 31 receptors receptor NNS cord-015021-pol2qm74 8059 32 on on IN cord-015021-pol2qm74 8059 33 the the DT cord-015021-pol2qm74 8059 34 de de FW cord-015021-pol2qm74 8059 35 novo novo NNP cord-015021-pol2qm74 8059 36 generation generation NN cord-015021-pol2qm74 8059 37 of of IN cord-015021-pol2qm74 8059 38 BK~ bk~ JJ cord-015021-pol2qm74 8059 39 receptors receptor NNS cord-015021-pol2qm74 8059 40 ( ( -LRB- cord-015021-pol2qm74 8059 41 reflected reflect VBN cord-015021-pol2qm74 8059 42 by by IN cord-015021-pol2qm74 8059 43 hypotensive hypotensive JJ cord-015021-pol2qm74 8059 44 responses response NNS cord-015021-pol2qm74 8059 45 to to IN cord-015021-pol2qm74 8059 46 a a DT cord-015021-pol2qm74 8059 47 BK BK NNP cord-015021-pol2qm74 8059 48 1 1 CD cord-015021-pol2qm74 8059 49 agonist agonist NN cord-015021-pol2qm74 8059 50 ) ) -RRB- cord-015021-pol2qm74 8059 51 in in IN cord-015021-pol2qm74 8059 52 the the DT cord-015021-pol2qm74 8059 53 LPS LPS NNP cord-015021-pol2qm74 8059 54 - - HYPH cord-015021-pol2qm74 8059 55 treated treat VBN cord-015021-pol2qm74 8059 56 ( ( -LRB- cord-015021-pol2qm74 8059 57 10ug 10ug NN cord-015021-pol2qm74 8059 58 iv iv CD cord-015021-pol2qm74 8059 59 ) ) -RRB- cord-015021-pol2qm74 8059 60 rabbit rabbit NN cord-015021-pol2qm74 8059 61 . . . cord-015021-pol2qm74 8060 1 In in IN cord-015021-pol2qm74 8060 2 LPS lp NNS cord-015021-pol2qm74 8060 3 treated treat VBD cord-015021-pol2qm74 8060 4 rabbits rabbit NNS cord-015021-pol2qm74 8060 5 hypotensive hypotensive JJ cord-015021-pol2qm74 8060 6 responses response NNS cord-015021-pol2qm74 8060 7 to to IN cord-015021-pol2qm74 8060 8 BK~ bk~ VB cord-015021-pol2qm74 8060 9 but but CC cord-015021-pol2qm74 8060 10 not not RB cord-015021-pol2qm74 8060 11 BK BK NNP cord-015021-pol2qm74 8060 12 2 2 CD cord-015021-pol2qm74 8060 13 agonists agonist NNS cord-015021-pol2qm74 8060 14 increased increase VBD cord-015021-pol2qm74 8060 15 with with IN cord-015021-pol2qm74 8060 16 time time NN cord-015021-pol2qm74 8060 17 and and CC cord-015021-pol2qm74 8060 18 at at IN cord-015021-pol2qm74 8060 19 time time NN cord-015021-pol2qm74 8060 20 210min 210min CD cord-015021-pol2qm74 8060 21 appeared appear VBD cord-015021-pol2qm74 8060 22 maximally maximally RB cord-015021-pol2qm74 8060 23 induced induce VBN cord-015021-pol2qm74 8060 24 . . . cord-015021-pol2qm74 8061 1 Constant constant JJ cord-015021-pol2qm74 8061 2 iv iv IN cord-015021-pol2qm74 8061 3 infusions infusion NNS cord-015021-pol2qm74 8061 4 of of IN cord-015021-pol2qm74 8061 5 CP-0127 CP-0127 NNP cord-015021-pol2qm74 8061 6 blocked block VBD cord-015021-pol2qm74 8061 7 BK BK NNP cord-015021-pol2qm74 8061 8 2 2 CD cord-015021-pol2qm74 8061 9 but but CC cord-015021-pol2qm74 8061 10 not not RB cord-015021-pol2qm74 8061 11 BK~ BK~ VBN cord-015021-pol2qm74 8061 12 and and CC cord-015021-pol2qm74 8061 13 CP-0298 CP-0298 NNS cord-015021-pol2qm74 8061 14 BK~ BK~ VBN cord-015021-pol2qm74 8062 1 but but CC cord-015021-pol2qm74 8062 2 not not RB cord-015021-pol2qm74 8062 3 BK BK NNP cord-015021-pol2qm74 8062 4 2 2 CD cord-015021-pol2qm74 8062 5 responses response NNS cord-015021-pol2qm74 8062 6 . . . cord-015021-pol2qm74 8063 1 CP-0364,CP-0127+CP-0298 CP-0364,CP-0127+CP-0298 NNPS cord-015021-pol2qm74 8063 2 and and CC cord-015021-pol2qm74 8063 3 Antril+CP-0364 Antril+CP-0364 NNP cord-015021-pol2qm74 8063 4 blocked block VBD cord-015021-pol2qm74 8063 5 both both DT cord-015021-pol2qm74 8063 6 BK BK NNP cord-015021-pol2qm74 8063 7 2 2 CD cord-015021-pol2qm74 8063 8 and and CC cord-015021-pol2qm74 8063 9 BK~ bk~ JJ cord-015021-pol2qm74 8063 10 responses response NNS cord-015021-pol2qm74 8063 11 . . . cord-015021-pol2qm74 8064 1 Antril Antril NNP cord-015021-pol2qm74 8064 2 alone alone RB cord-015021-pol2qm74 8064 3 had have VBD cord-015021-pol2qm74 8064 4 no no DT cord-015021-pol2qm74 8064 5 effect effect NN cord-015021-pol2qm74 8064 6 on on IN cord-015021-pol2qm74 8064 7 BK BK NNP cord-015021-pol2qm74 8064 8 2 2 CD cord-015021-pol2qm74 8064 9 or or CC cord-015021-pol2qm74 8064 10 BK~ bk~ JJ cord-015021-pol2qm74 8064 11 responses response NNS cord-015021-pol2qm74 8064 12 . . . cord-015021-pol2qm74 8065 1 Within within IN cord-015021-pol2qm74 8065 2 30 30 CD cord-015021-pol2qm74 8065 3 - - SYM cord-015021-pol2qm74 8065 4 60 60 CD cord-015021-pol2qm74 8065 5 min min NN cord-015021-pol2qm74 8065 6 after after IN cord-015021-pol2qm74 8065 7 stopping stop VBG cord-015021-pol2qm74 8065 8 the the DT cord-015021-pol2qm74 8065 9 infusions infusion NNS cord-015021-pol2qm74 8065 10 of of IN cord-015021-pol2qm74 8065 11 antagonists antagonist NNS cord-015021-pol2qm74 8065 12 the the DT cord-015021-pol2qm74 8065 13 responses response NNS cord-015021-pol2qm74 8065 14 to to TO cord-015021-pol2qm74 8065 15 BK~ BK~ NNP cord-015021-pol2qm74 8065 16 and and CC cord-015021-pol2qm74 8065 17 BK BK NNP cord-015021-pol2qm74 8065 18 z z NNP cord-015021-pol2qm74 8065 19 agonists agonist NNS cord-015021-pol2qm74 8065 20 were be VBD cord-015021-pol2qm74 8065 21 the the DT cord-015021-pol2qm74 8065 22 same same JJ cord-015021-pol2qm74 8065 23 as as IN cord-015021-pol2qm74 8065 24 those those DT cord-015021-pol2qm74 8065 25 in in IN cord-015021-pol2qm74 8065 26 nonantagonist nonantagonist NN cord-015021-pol2qm74 8065 27 infused infuse VBN cord-015021-pol2qm74 8065 28 rabbits rabbit NNS cord-015021-pol2qm74 8065 29 . . . cord-015021-pol2qm74 8066 1 These these DT cord-015021-pol2qm74 8066 2 results result NNS cord-015021-pol2qm74 8066 3 indicate indicate VBP cord-015021-pol2qm74 8066 4 , , , cord-015021-pol2qm74 8066 5 at at IN cord-015021-pol2qm74 8066 6 least least JJS cord-015021-pol2qm74 8066 7 in in IN cord-015021-pol2qm74 8066 8 the the DT cord-015021-pol2qm74 8066 9 LPS LPS NNP cord-015021-pol2qm74 8066 10 - - HYPH cord-015021-pol2qm74 8066 11 treated treat VBN cord-015021-pol2qm74 8066 12 rabbit rabbit NN cord-015021-pol2qm74 8066 13 , , , cord-015021-pol2qm74 8066 14 that that IN cord-015021-pol2qm74 8066 15 neither neither CC cord-015021-pol2qm74 8066 16 BK2,BK bk2,bk NN cord-015021-pol2qm74 8066 17 ~ ~ NFP cord-015021-pol2qm74 8066 18 or or CC cord-015021-pol2qm74 8066 19 ILl ill JJ cord-015021-pol2qm74 8066 20 receptors receptor NNS cord-015021-pol2qm74 8066 21 alone alone RB cord-015021-pol2qm74 8066 22 or or CC cord-015021-pol2qm74 8066 23 in in IN cord-015021-pol2qm74 8066 24 combination combination NN cord-015021-pol2qm74 8066 25 , , , cord-015021-pol2qm74 8066 26 are be VBP cord-015021-pol2qm74 8066 27 involved involve VBN cord-015021-pol2qm74 8066 28 in in IN cord-015021-pol2qm74 8066 29 the the DT cord-015021-pol2qm74 8066 30 de de FW cord-015021-pol2qm74 8066 31 novo novo NNP cord-015021-pol2qm74 8066 32 generation generation NN cord-015021-pol2qm74 8066 33 of of IN cord-015021-pol2qm74 8066 34 BK BK NNP cord-015021-pol2qm74 8066 35 1 1 CD cord-015021-pol2qm74 8066 36 receptors receptor NNS cord-015021-pol2qm74 8066 37 . . . cord-015021-pol2qm74 8067 1 In in IN cord-015021-pol2qm74 8067 2 vitro vitro FW cord-015021-pol2qm74 8067 3 studies study NNS cord-015021-pol2qm74 8067 4 demonstrated demonstrate VBD cord-015021-pol2qm74 8067 5 that that IN cord-015021-pol2qm74 8067 6 beth beth NNP cord-015021-pol2qm74 8067 7 Bradycor Bradycor NNP cord-015021-pol2qm74 8067 8 and and CC cord-015021-pol2qm74 8067 9 CP-0364 CP-0364 NNP cord-015021-pol2qm74 8067 10 ( ( -LRB- cord-015021-pol2qm74 8067 11 but but CC cord-015021-pol2qm74 8067 12 not not RB cord-015021-pol2qm74 8067 13 Antril Antril NNP cord-015021-pol2qm74 8067 14 ) ) -RRB- cord-015021-pol2qm74 8067 15 were be VBD cord-015021-pol2qm74 8067 16 antagonists antagonist NNS cord-015021-pol2qm74 8067 17 at at IN cord-015021-pol2qm74 8067 18 both both DT cord-015021-pol2qm74 8067 19 BK BK NNP cord-015021-pol2qm74 8067 20 z z NNP cord-015021-pol2qm74 8067 21 and and CC cord-015021-pol2qm74 8067 22 BK~ bk~ JJ cord-015021-pol2qm74 8067 23 receptors receptor NNS cord-015021-pol2qm74 8067 24 . . . cord-015021-pol2qm74 8068 1 If if IN cord-015021-pol2qm74 8068 2 both both DT cord-015021-pol2qm74 8068 3 BK BK NNP cord-015021-pol2qm74 8068 4 z z NNP cord-015021-pol2qm74 8068 5 and and CC cord-015021-pol2qm74 8068 6 BK BK NNP cord-015021-pol2qm74 8068 7 1 1 CD cord-015021-pol2qm74 8068 8 receptors receptor NNS cord-015021-pol2qm74 8068 9 are be VBP cord-015021-pol2qm74 8068 10 significantly significantly RB cord-015021-pol2qm74 8068 11 involved involve VBN cord-015021-pol2qm74 8068 12 in in IN cord-015021-pol2qm74 8068 13 chronic chronic JJ cord-015021-pol2qm74 8068 14 inflammatory inflammatory JJ cord-015021-pol2qm74 8068 15 situations situation NNS cord-015021-pol2qm74 8068 16 in in IN cord-015021-pol2qm74 8068 17 man man NN cord-015021-pol2qm74 8068 18 such such JJ cord-015021-pol2qm74 8068 19 as as IN cord-015021-pol2qm74 8068 20 SIRS SIRS NNP cord-015021-pol2qm74 8068 21 / / SYM cord-015021-pol2qm74 8068 22 sepsis sepsis NN cord-015021-pol2qm74 8069 1 then then RB cord-015021-pol2qm74 8069 2 the the DT cord-015021-pol2qm74 8069 3 rationale rationale NN cord-015021-pol2qm74 8069 4 for for IN cord-015021-pol2qm74 8069 5 the the DT cord-015021-pol2qm74 8069 6 use use NN cord-015021-pol2qm74 8069 7 of of IN cord-015021-pol2qm74 8069 8 compounds compound NNS cord-015021-pol2qm74 8069 9 such such JJ cord-015021-pol2qm74 8069 10 as as IN cord-015021-pol2qm74 8069 11 Bradycor Bradycor NNP cord-015021-pol2qm74 8069 12 or or CC cord-015021-pol2qm74 8069 13 CP-0364 CP-0364 NNP cord-015021-pol2qm74 8069 14 is be VBZ cord-015021-pol2qm74 8069 15 clear clear JJ cord-015021-pol2qm74 8069 16 . . . cord-015021-pol2qm74 8070 1 Infection infection NN cord-015021-pol2qm74 8070 2 is be VBZ cord-015021-pol2qm74 8070 3 a a DT cord-015021-pol2qm74 8070 4 major major JJ cord-015021-pol2qm74 8070 5 cause cause NN cord-015021-pol2qm74 8070 6 of of IN cord-015021-pol2qm74 8070 7 or or CC cord-015021-pol2qm74 8070 8 contributor contributor NN cord-015021-pol2qm74 8070 9 for for IN cord-015021-pol2qm74 8070 10 morbidity morbidity NN cord-015021-pol2qm74 8070 11 and and CC cord-015021-pol2qm74 8070 12 mortality mortality NN cord-015021-pol2qm74 8070 13 in in IN cord-015021-pol2qm74 8070 14 liver liver NN cord-015021-pol2qm74 8070 15 transplant transplant NN cord-015021-pol2qm74 8070 16 recipients recipient NNS cord-015021-pol2qm74 8070 17 . . . cord-015021-pol2qm74 8071 1 Effectiveness effectiveness NN cord-015021-pol2qm74 8071 2 of of IN cord-015021-pol2qm74 8071 3 prophylactic prophylactic JJ cord-015021-pol2qm74 8071 4 and and CC cord-015021-pol2qm74 8071 5 therapeutic therapeutic JJ cord-015021-pol2qm74 8071 6 protocols protocol NNS cord-015021-pol2qm74 8071 7 is be VBZ cord-015021-pol2qm74 8071 8 important important JJ cord-015021-pol2qm74 8071 9 for for IN cord-015021-pol2qm74 8071 10 the the DT cord-015021-pol2qm74 8071 11 success success NN cord-015021-pol2qm74 8071 12 of of IN cord-015021-pol2qm74 8071 13 liver liver NN cord-015021-pol2qm74 8071 14 transplantation transplantation NN cord-015021-pol2qm74 8071 15 ( ( -LRB- cord-015021-pol2qm74 8071 16 OLT OLT NNP cord-015021-pol2qm74 8071 17 ) ) -RRB- cord-015021-pol2qm74 8071 18 . . . cord-015021-pol2qm74 8072 1 SDD SDD NNP cord-015021-pol2qm74 8072 2 is be VBZ cord-015021-pol2qm74 8072 3 used use VBN cord-015021-pol2qm74 8072 4 as as IN cord-015021-pol2qm74 8072 5 prophylaxis prophylaxis NN cord-015021-pol2qm74 8072 6 for for IN cord-015021-pol2qm74 8072 7 reduction reduction NN cord-015021-pol2qm74 8072 8 of of IN cord-015021-pol2qm74 8072 9 infection infection NN cord-015021-pol2qm74 8072 10 caused cause VBN cord-015021-pol2qm74 8072 11 by by IN cord-015021-pol2qm74 8072 12 Gram Gram NNP cord-015021-pol2qm74 8072 13 negative negative JJ cord-015021-pol2qm74 8072 14 or or CC cord-015021-pol2qm74 8072 15 fungal fungal JJ cord-015021-pol2qm74 8072 16 microorganisms microorganism NNS cord-015021-pol2qm74 8072 17 . . . cord-015021-pol2qm74 8073 1 Between between IN cord-015021-pol2qm74 8073 2 September September NNP cord-015021-pol2qm74 8073 3 1988 1988 CD cord-015021-pol2qm74 8073 4 and and CC cord-015021-pol2qm74 8073 5 July July NNP cord-015021-pol2qm74 8073 6 1993 1993 CD cord-015021-pol2qm74 8073 7 400 400 CD cord-015021-pol2qm74 8073 8 OLT OLT NNP cord-015021-pol2qm74 8073 9 's 's POS cord-015021-pol2qm74 8073 10 in in IN cord-015021-pol2qm74 8073 11 368 368 CD cord-015021-pol2qm74 8073 12 patients patient NNS cord-015021-pol2qm74 8073 13 were be VBD cord-015021-pol2qm74 8073 14 performed perform VBN cord-015021-pol2qm74 8073 15 at at IN cord-015021-pol2qm74 8073 16 our -PRON- PRP$ cord-015021-pol2qm74 8073 17 department department NN cord-015021-pol2qm74 8073 18 . . . cord-015021-pol2qm74 8074 1 The the DT cord-015021-pol2qm74 8074 2 actuarial actuarial JJ cord-015021-pol2qm74 8074 3 1-year 1-year CD cord-015021-pol2qm74 8074 4 patient patient JJ cord-015021-pol2qm74 8074 5 survival survival NN cord-015021-pol2qm74 8074 6 is be VBZ cord-015021-pol2qm74 8074 7 90 90 CD cord-015021-pol2qm74 8074 8 % % NN cord-015021-pol2qm74 8074 9 . . . cord-015021-pol2qm74 8075 1 Infection infection NN cord-015021-pol2qm74 8075 2 prophylaxis prophylaxis NN cord-015021-pol2qm74 8075 3 is be VBZ cord-015021-pol2qm74 8075 4 started start VBN cord-015021-pol2qm74 8075 5 with with IN cord-015021-pol2qm74 8075 6 SDD SDD NNP cord-015021-pol2qm74 8075 7 and and CC cord-015021-pol2qm74 8075 8 ciprofloxacin ciprofloxacin NN cord-015021-pol2qm74 8075 9 once once IN cord-015021-pol2qm74 8075 10 the the DT cord-015021-pol2qm74 8075 11 patient patient NN cord-015021-pol2qm74 8075 12 is be VBZ cord-015021-pol2qm74 8075 13 accepted accept VBN cord-015021-pol2qm74 8075 14 as as IN cord-015021-pol2qm74 8075 15 an an DT cord-015021-pol2qm74 8075 16 OLT OLT NNP cord-015021-pol2qm74 8075 17 candidate candidate NN cord-015021-pol2qm74 8075 18 . . . cord-015021-pol2qm74 8076 1 Perioperatively Perioperatively NNP cord-015021-pol2qm74 8076 2 metronidazol metronidazol NNP cord-015021-pol2qm74 8076 3 , , , cord-015021-pol2qm74 8076 4 tobramycin tobramycin NNPS cord-015021-pol2qm74 8076 5 and and CC cord-015021-pol2qm74 8076 6 cefotaxim cefotaxim NNP cord-015021-pol2qm74 8076 7 , , , cord-015021-pol2qm74 8076 8 postoperatively postoperatively RB cord-015021-pol2qm74 8076 9 cotrimoxazol cotrimoxazol NNP cord-015021-pol2qm74 8076 10 are be VBP cord-015021-pol2qm74 8076 11 prescribed prescribe VBN cord-015021-pol2qm74 8076 12 additionally additionally RB cord-015021-pol2qm74 8076 13 . . . cord-015021-pol2qm74 8077 1 The the DT cord-015021-pol2qm74 8077 2 table table NN cord-015021-pol2qm74 8077 3 shows show VBZ cord-015021-pol2qm74 8077 4 Pneumonia pneumonia NN cord-015021-pol2qm74 8077 5 , , , cord-015021-pol2qm74 8077 6 peritonitis peritonitis NN cord-015021-pol2qm74 8077 7 , , , cord-015021-pol2qm74 8077 8 major major JJ cord-015021-pol2qm74 8077 9 wound wound NN cord-015021-pol2qm74 8077 10 and and CC cord-015021-pol2qm74 8077 11 urinary urinary JJ cord-015021-pol2qm74 8077 12 tract tract NN cord-015021-pol2qm74 8077 13 infection infection NN cord-015021-pol2qm74 8077 14 are be VBP cord-015021-pol2qm74 8077 15 common common JJ cord-015021-pol2qm74 8077 16 nosocomial nosocomial JJ cord-015021-pol2qm74 8077 17 infections infection NNS cord-015021-pol2qm74 8077 18 following follow VBG cord-015021-pol2qm74 8077 19 severe severe JJ cord-015021-pol2qm74 8077 20 injury injury NN cord-015021-pol2qm74 8077 21 . . . cord-015021-pol2qm74 8078 1 In in IN cord-015021-pol2qm74 8078 2 a a DT cord-015021-pol2qm74 8078 3 series series NN cord-015021-pol2qm74 8078 4 of of IN cord-015021-pol2qm74 8078 5 severely severely RB cord-015021-pol2qm74 8078 6 injured injure VBN cord-015021-pol2qm74 8078 7 patients patient NNS cord-015021-pol2qm74 8078 8 from from IN cord-015021-pol2qm74 8078 9 the the DT cord-015021-pol2qm74 8078 10 University University NNP cord-015021-pol2qm74 8078 11 of of IN cord-015021-pol2qm74 8078 12 Louisville Louisville NNP cord-015021-pol2qm74 8078 13 Hospital Hospital NNP cord-015021-pol2qm74 8078 14 , , , cord-015021-pol2qm74 8078 15 pneumonia pneumonia NN cord-015021-pol2qm74 8078 16 was be VBD cord-015021-pol2qm74 8078 17 the the DT cord-015021-pol2qm74 8078 18 most most RBS cord-015021-pol2qm74 8078 19 common common JJ cord-015021-pol2qm74 8078 20 infection infection NN cord-015021-pol2qm74 8078 21 followed follow VBN cord-015021-pol2qm74 8078 22 by by IN cord-015021-pol2qm74 8078 23 peritonitis peritonitis NN cord-015021-pol2qm74 8078 24 , , , cord-015021-pol2qm74 8078 25 intra intra JJ cord-015021-pol2qm74 8078 26 - - JJ cord-015021-pol2qm74 8078 27 abdominal abdominal JJ cord-015021-pol2qm74 8078 28 abscess abscess NN cord-015021-pol2qm74 8078 29 formation formation NN cord-015021-pol2qm74 8078 30 and and CC cord-015021-pol2qm74 8078 31 burn burn VB cord-015021-pol2qm74 8078 32 wound wound NN cord-015021-pol2qm74 8078 33 infection infection NN cord-015021-pol2qm74 8078 34 . . . cord-015021-pol2qm74 8079 1 Pneumonia pneumonia NN cord-015021-pol2qm74 8079 2 is be VBZ cord-015021-pol2qm74 8079 3 actually actually RB cord-015021-pol2qm74 8079 4 the the DT cord-015021-pol2qm74 8079 5 leading leading JJ cord-015021-pol2qm74 8079 6 cause cause NN cord-015021-pol2qm74 8079 7 of of IN cord-015021-pol2qm74 8079 8 death death NN cord-015021-pol2qm74 8079 9 from from IN cord-015021-pol2qm74 8079 10 nosocomial nosocomial JJ cord-015021-pol2qm74 8079 11 infection infection NN cord-015021-pol2qm74 8079 12 . . . cord-015021-pol2qm74 8080 1 These these DT cord-015021-pol2qm74 8080 2 are be VBP cord-015021-pol2qm74 8080 3 defined define VBN cord-015021-pol2qm74 8080 4 as as IN cord-015021-pol2qm74 8080 5 occurring occur VBG cord-015021-pol2qm74 8080 6 from from IN cord-015021-pol2qm74 8080 7 48 48 CD cord-015021-pol2qm74 8080 8 to to TO cord-015021-pol2qm74 8080 9 72 72 CD cord-015021-pol2qm74 8080 10 hours hour NNS cord-015021-pol2qm74 8080 11 after after IN cord-015021-pol2qm74 8080 12 hospital hospital NN cord-015021-pol2qm74 8080 13 admission admission NN cord-015021-pol2qm74 8080 14 . . . cord-015021-pol2qm74 8081 1 This this DT cord-015021-pol2qm74 8081 2 definition definition NN cord-015021-pol2qm74 8081 3 has have VBZ cord-015021-pol2qm74 8081 4 important important JJ cord-015021-pol2qm74 8081 5 implications implication NNS cord-015021-pol2qm74 8081 6 for for IN cord-015021-pol2qm74 8081 7 antibiotic antibiotic JJ cord-015021-pol2qm74 8081 8 therapy therapy NN cord-015021-pol2qm74 8081 9 because because IN cord-015021-pol2qm74 8081 10 the the DT cord-015021-pol2qm74 8081 11 likely likely JJ cord-015021-pol2qm74 8081 12 pathogens pathogen NNS cord-015021-pol2qm74 8081 13 and and CC cord-015021-pol2qm74 8081 14 their -PRON- PRP$ cord-015021-pol2qm74 8081 15 respective respective JJ cord-015021-pol2qm74 8081 16 sensitivities sensitivity NNS cord-015021-pol2qm74 8081 17 are be VBP cord-015021-pol2qm74 8081 18 different different JJ cord-015021-pol2qm74 8081 19 for for IN cord-015021-pol2qm74 8081 20 community community NN cord-015021-pol2qm74 8081 21 acquired acquire VBD cord-015021-pol2qm74 8081 22 pneumonia pneumonia NN cord-015021-pol2qm74 8081 23 . . . cord-015021-pol2qm74 8082 1 The the DT cord-015021-pol2qm74 8082 2 diagnosis diagnosis NN cord-015021-pol2qm74 8082 3 of of IN cord-015021-pol2qm74 8082 4 nosocomial nosocomial JJ cord-015021-pol2qm74 8082 5 pneumonia pneumonia NN cord-015021-pol2qm74 8082 6 is be VBZ cord-015021-pol2qm74 8082 7 difficult difficult JJ cord-015021-pol2qm74 8082 8 following follow VBG cord-015021-pol2qm74 8082 9 major major JJ cord-015021-pol2qm74 8082 10 injury injury NN cord-015021-pol2qm74 8082 11 as as IN cord-015021-pol2qm74 8082 12 many many JJ cord-015021-pol2qm74 8082 13 patients patient NNS cord-015021-pol2qm74 8082 14 will will MD cord-015021-pol2qm74 8082 15 have have VB cord-015021-pol2qm74 8082 16 pre pre JJ cord-015021-pol2qm74 8082 17 - - JJ cord-015021-pol2qm74 8082 18 existing existing JJ cord-015021-pol2qm74 8082 19 fever fever NN cord-015021-pol2qm74 8082 20 , , , cord-015021-pol2qm74 8082 21 leukocytosis leukocytosis NN cord-015021-pol2qm74 8082 22 , , , cord-015021-pol2qm74 8082 23 tachypnea tachypnea NNP cord-015021-pol2qm74 8082 24 , , , cord-015021-pol2qm74 8082 25 and and CC cord-015021-pol2qm74 8082 26 chest chest NN cord-015021-pol2qm74 8082 27 X x NN cord-015021-pol2qm74 8082 28 - - NN cord-015021-pol2qm74 8082 29 ray ray JJ cord-015021-pol2qm74 8082 30 changes change NNS cord-015021-pol2qm74 8082 31 . . . cord-015021-pol2qm74 8083 1 Reliance reliance NN cord-015021-pol2qm74 8083 2 on on IN cord-015021-pol2qm74 8083 3 sputum sputum NN cord-015021-pol2qm74 8083 4 gram gram NN cord-015021-pol2qm74 8083 5 stain stain NN cord-015021-pol2qm74 8083 6 and and CC cord-015021-pol2qm74 8083 7 culture culture NN cord-015021-pol2qm74 8083 8 is be VBZ cord-015021-pol2qm74 8083 9 important important JJ cord-015021-pol2qm74 8083 10 and and CC cord-015021-pol2qm74 8083 11 best well RBS cord-015021-pol2qm74 8083 12 obtained obtain VBN cord-015021-pol2qm74 8083 13 by by IN cord-015021-pol2qm74 8083 14 a a DT cord-015021-pol2qm74 8083 15 bronchoalveolar bronchoalveolar JJ cord-015021-pol2qm74 8083 16 lavage lavage NN cord-015021-pol2qm74 8083 17 or or CC cord-015021-pol2qm74 8083 18 protected protect VBN cord-015021-pol2qm74 8083 19 specimen specimen JJ cord-015021-pol2qm74 8083 20 brush brush NN cord-015021-pol2qm74 8083 21 during during IN cord-015021-pol2qm74 8083 22 bronchoscopy bronchoscopy NN cord-015021-pol2qm74 8083 23 . . . cord-015021-pol2qm74 8084 1 Predisposing predispose VBG cord-015021-pol2qm74 8084 2 risk risk NN cord-015021-pol2qm74 8084 3 factors factor NNS cord-015021-pol2qm74 8084 4 include include VBP cord-015021-pol2qm74 8084 5 severe severe JJ cord-015021-pol2qm74 8084 6 head head NN cord-015021-pol2qm74 8084 7 injury injury NN cord-015021-pol2qm74 8084 8 , , , cord-015021-pol2qm74 8084 9 emergent emergent JJ cord-015021-pol2qm74 8084 10 intubation intubation NN cord-015021-pol2qm74 8084 11 and and CC cord-015021-pol2qm74 8084 12 shock shock NN cord-015021-pol2qm74 8084 13 , , , cord-015021-pol2qm74 8084 14 and and CC cord-015021-pol2qm74 8084 15 such such JJ cord-015021-pol2qm74 8084 16 patients patient NNS cord-015021-pol2qm74 8084 17 have have VBP cord-015021-pol2qm74 8084 18 been be VBN cord-015021-pol2qm74 8084 19 shown show VBN cord-015021-pol2qm74 8084 20 to to TO cord-015021-pol2qm74 8084 21 benefit benefit VB cord-015021-pol2qm74 8084 22 by by IN cord-015021-pol2qm74 8084 23 early early JJ cord-015021-pol2qm74 8084 24 tracheostomy tracheostomy NN cord-015021-pol2qm74 8084 25 . . . cord-015021-pol2qm74 8085 1 Staph Staph NNP cord-015021-pol2qm74 8085 2 aureus aureus NN cord-015021-pol2qm74 8085 3 has have VBZ cord-015021-pol2qm74 8085 4 been be VBN cord-015021-pol2qm74 8085 5 the the DT cord-015021-pol2qm74 8085 6 most most RBS cord-015021-pol2qm74 8085 7 common common JJ cord-015021-pol2qm74 8085 8 pathogen pathogen NN cord-015021-pol2qm74 8085 9 isolated isolate VBN cord-015021-pol2qm74 8085 10 from from IN cord-015021-pol2qm74 8085 11 the the DT cord-015021-pol2qm74 8085 12 sputum sputum NN cord-015021-pol2qm74 8085 13 and and CC cord-015021-pol2qm74 8085 14 the the DT cord-015021-pol2qm74 8085 15 remainder remainder NN cord-015021-pol2qm74 8085 16 gram gram NN cord-015021-pol2qm74 8085 17 - - HYPH cord-015021-pol2qm74 8085 18 negative negative JJ cord-015021-pol2qm74 8085 19 organisms organism NNS cord-015021-pol2qm74 8085 20 with with IN cord-015021-pol2qm74 8085 21 Pseudomonas Pseudomonas NNP cord-015021-pol2qm74 8085 22 aeruginosa aeruginosa NN cord-015021-pol2qm74 8085 23 , , , cord-015021-pol2qm74 8085 24 and and CC cord-015021-pol2qm74 8085 25 Klebsiella Klebsiella NNP cord-015021-pol2qm74 8085 26 pneumonia pneumonia NN cord-015021-pol2qm74 8085 27 predominating predominate VBG cord-015021-pol2qm74 8085 28 . . . cord-015021-pol2qm74 8086 1 Bacteria Bacteria NNS cord-015021-pol2qm74 8086 2 recovered recover VBN cord-015021-pol2qm74 8086 3 by by IN cord-015021-pol2qm74 8086 4 site site NN cord-015021-pol2qm74 8086 5 as as RB cord-015021-pol2qm74 8086 6 well well RB cord-015021-pol2qm74 8086 7 as as IN cord-015021-pol2qm74 8086 8 by by IN cord-015021-pol2qm74 8086 9 intensive intensive JJ cord-015021-pol2qm74 8086 10 care care NN cord-015021-pol2qm74 8086 11 unit unit NN cord-015021-pol2qm74 8086 12 is be VBZ cord-015021-pol2qm74 8086 13 published publish VBN cord-015021-pol2qm74 8086 14 in in IN cord-015021-pol2qm74 8086 15 the the DT cord-015021-pol2qm74 8086 16 six six CD cord-015021-pol2qm74 8086 17 month month NN cord-015021-pol2qm74 8086 18 antibiogram antibiogram NNP cord-015021-pol2qm74 8086 19 which which WDT cord-015021-pol2qm74 8086 20 also also RB cord-015021-pol2qm74 8086 21 includes include VBZ cord-015021-pol2qm74 8086 22 recent recent JJ cord-015021-pol2qm74 8086 23 antibiotic antibiotic JJ cord-015021-pol2qm74 8086 24 sensitivities sensitivity NNS cord-015021-pol2qm74 8086 25 . . . cord-015021-pol2qm74 8087 1 This this DT cord-015021-pol2qm74 8087 2 aids aid VBZ cord-015021-pol2qm74 8087 3 in in IN cord-015021-pol2qm74 8087 4 empiric empiric JJ cord-015021-pol2qm74 8087 5 antibiotic antibiotic JJ cord-015021-pol2qm74 8087 6 selection selection NN cord-015021-pol2qm74 8087 7 against against IN cord-015021-pol2qm74 8087 8 such such JJ cord-015021-pol2qm74 8087 9 nosocomial nosocomial JJ cord-015021-pol2qm74 8087 10 organisms organism NNS cord-015021-pol2qm74 8087 11 . . . cord-015021-pol2qm74 8088 1 In in IN cord-015021-pol2qm74 8088 2 a a DT cord-015021-pol2qm74 8088 3 series series NN cord-015021-pol2qm74 8088 4 of of IN cord-015021-pol2qm74 8088 5 severely severely RB cord-015021-pol2qm74 8088 6 injured injure VBN cord-015021-pol2qm74 8088 7 patients patient NNS cord-015021-pol2qm74 8088 8 ( ( -LRB- cord-015021-pol2qm74 8088 9 ISS ISS NNP cord-015021-pol2qm74 8088 10 -30 -30 NNP cord-015021-pol2qm74 8088 11 ) ) -RRB- cord-015021-pol2qm74 8088 12 , , , cord-015021-pol2qm74 8088 13 mean mean JJ cord-015021-pol2qm74 8088 14 temp temp NN cord-015021-pol2qm74 8088 15 . . . cord-015021-pol2qm74 8089 1 was be VBD cord-015021-pol2qm74 8089 2 101.4F 101.4f CD cord-015021-pol2qm74 8090 1 , , , cord-015021-pol2qm74 8090 2 leukocytosis leukocytosis NNP cord-015021-pol2qm74 8090 3 was be VBD cord-015021-pol2qm74 8090 4 16k 16k CD cord-015021-pol2qm74 8090 5 , , , cord-015021-pol2qm74 8090 6 Pan2 Pan2 NNP cord-015021-pol2qm74 8090 7 was be VBD cord-015021-pol2qm74 8090 8 87 87 CD cord-015021-pol2qm74 8090 9 , , , cord-015021-pol2qm74 8090 10 Fin2 Fin2 NNP cord-015021-pol2qm74 8090 11 was be VBD cord-015021-pol2qm74 8090 12 .47 .47 CD cord-015021-pol2qm74 8090 13 , , , cord-015021-pol2qm74 8090 14 and and CC cord-015021-pol2qm74 8090 15 PEEP PEEP NNP cord-015021-pol2qm74 8090 16 was be VBD cord-015021-pol2qm74 8090 17 5.1 5.1 CD cord-015021-pol2qm74 8090 18 at at IN cord-015021-pol2qm74 8090 19 the the DT cord-015021-pol2qm74 8090 20 time time NN cord-015021-pol2qm74 8090 21 of of IN cord-015021-pol2qm74 8090 22 diagnosis diagnosis NN cord-015021-pol2qm74 8090 23 ( ( -LRB- cord-015021-pol2qm74 8090 24 ARDS ARDS NNP cord-015021-pol2qm74 8090 25 excluded exclude VBD cord-015021-pol2qm74 8090 26 ) ) -RRB- cord-015021-pol2qm74 8090 27 . . . cord-015021-pol2qm74 8091 1 There there EX cord-015021-pol2qm74 8091 2 was be VBD cord-015021-pol2qm74 8091 3 marked mark VBN cord-015021-pol2qm74 8091 4 reduction reduction NN cord-015021-pol2qm74 8091 5 in in IN cord-015021-pol2qm74 8091 6 class class NN cord-015021-pol2qm74 8091 7 II II NNP cord-015021-pol2qm74 8091 8 histocompatibility histocompatibility NN cord-015021-pol2qm74 8091 9 antigen antigen NN cord-015021-pol2qm74 8091 10 ( ( -LRB- cord-015021-pol2qm74 8091 11 HLA HLA NNP cord-015021-pol2qm74 8091 12 - - HYPH cord-015021-pol2qm74 8091 13 DR DR NNP cord-015021-pol2qm74 8091 14 ) ) -RRB- cord-015021-pol2qm74 8091 15 density density NN cord-015021-pol2qm74 8091 16 on on IN cord-015021-pol2qm74 8091 17 peripheral peripheral JJ cord-015021-pol2qm74 8091 18 and and CC cord-015021-pol2qm74 8091 19 BAL BAL NNP cord-015021-pol2qm74 8091 20 monocyte monocyte NNP cord-015021-pol2qm74 8091 21 / / SYM cord-015021-pol2qm74 8091 22 macrophages macrophage NNS cord-015021-pol2qm74 8091 23 which which WDT cord-015021-pol2qm74 8091 24 recovered recover VBD cord-015021-pol2qm74 8091 25 over over IN cord-015021-pol2qm74 8091 26 time time NN cord-015021-pol2qm74 8091 27 with with IN cord-015021-pol2qm74 8091 28 resolution resolution NN cord-015021-pol2qm74 8091 29 of of IN cord-015021-pol2qm74 8091 30 pneumonia pneumonia NN cord-015021-pol2qm74 8091 31 . . . cord-015021-pol2qm74 8092 1 Immune immune JJ cord-015021-pol2qm74 8092 2 suppression suppression NN cord-015021-pol2qm74 8092 3 occurred occur VBD cord-015021-pol2qm74 8092 4 prior prior RB cord-015021-pol2qm74 8092 5 to to IN cord-015021-pol2qm74 8092 6 development development NN cord-015021-pol2qm74 8092 7 of of IN cord-015021-pol2qm74 8092 8 pneumonia pneumonia NN cord-015021-pol2qm74 8092 9 , , , cord-015021-pol2qm74 8092 10 was be VBD cord-015021-pol2qm74 8092 11 especially especially RB cord-015021-pol2qm74 8092 12 localized localize VBN cord-015021-pol2qm74 8092 13 to to IN cord-015021-pol2qm74 8092 14 the the DT cord-015021-pol2qm74 8092 15 infected infected JJ cord-015021-pol2qm74 8092 16 tissue tissue NN cord-015021-pol2qm74 8092 17 , , , cord-015021-pol2qm74 8092 18 but but CC cord-015021-pol2qm74 8092 19 recovered recover VBN cord-015021-pol2qm74 8092 20 with with IN cord-015021-pol2qm74 8092 21 clinical clinical JJ cord-015021-pol2qm74 8092 22 improvement improvement NN cord-015021-pol2qm74 8092 23 . . . cord-015021-pol2qm74 8093 1 Specific specific JJ cord-015021-pol2qm74 8093 2 immune immune JJ cord-015021-pol2qm74 8093 3 modulation modulation NN cord-015021-pol2qm74 8093 4 targeted target VBN cord-015021-pol2qm74 8093 5 to to IN cord-015021-pol2qm74 8093 6 pulmonary pulmonary JJ cord-015021-pol2qm74 8093 7 white white JJ cord-015021-pol2qm74 8093 8 cells cell NNS cord-015021-pol2qm74 8093 9 may may MD cord-015021-pol2qm74 8093 10 hasten hasten VB cord-015021-pol2qm74 8093 11 clinical clinical JJ cord-015021-pol2qm74 8093 12 recovery recovery NN cord-015021-pol2qm74 8093 13 and and CC cord-015021-pol2qm74 8093 14 minimize minimize VB cord-015021-pol2qm74 8093 15 pulmonary pulmonary JJ cord-015021-pol2qm74 8093 16 dysfunction dysfunction NN cord-015021-pol2qm74 8093 17 . . . cord-015021-pol2qm74 8094 1 -CLINICAL -CLINICAL . cord-015021-pol2qm74 8095 1 EXPERIENCE EXPERIENCE NNP cord-015021-pol2qm74 8095 2 J. J. NNP cord-015021-pol2qm74 8095 3 Tnllemar Tnllemar NNP cord-015021-pol2qm74 8095 4 Amphntericin Amphntericin NNP cord-015021-pol2qm74 8095 5 B B NNP cord-015021-pol2qm74 8095 6 remains remain VBZ cord-015021-pol2qm74 8095 7 the the DT cord-015021-pol2qm74 8095 8 drug drug NN cord-015021-pol2qm74 8095 9 of of IN cord-015021-pol2qm74 8095 10 choice choice NN cord-015021-pol2qm74 8095 11 for for IN cord-015021-pol2qm74 8095 12 many many JJ cord-015021-pol2qm74 8095 13 systemic systemic JJ cord-015021-pol2qm74 8095 14 fungal fungal JJ cord-015021-pol2qm74 8095 15 infections infection NNS cord-015021-pol2qm74 8095 16 . . . cord-015021-pol2qm74 8096 1 Its -PRON- PRP$ cord-015021-pol2qm74 8096 2 advantages advantage NNS cord-015021-pol2qm74 8096 3 include include VBP cord-015021-pol2qm74 8096 4 a a DT cord-015021-pol2qm74 8096 5 broad broad JJ cord-015021-pol2qm74 8096 6 spectrum spectrum NN cord-015021-pol2qm74 8096 7 of of IN cord-015021-pol2qm74 8096 8 activity activity NN cord-015021-pol2qm74 8096 9 and and CC cord-015021-pol2qm74 8096 10 intravenous intravenous JJ cord-015021-pol2qm74 8096 11 administration administration NN cord-015021-pol2qm74 8096 12 . . . cord-015021-pol2qm74 8097 1 The the DT cord-015021-pol2qm74 8097 2 major major JJ cord-015021-pol2qm74 8097 3 disadvantages disadvantage NNS cord-015021-pol2qm74 8097 4 of of IN cord-015021-pol2qm74 8097 5 amphoterlcin amphoterlcin NNS cord-015021-pol2qm74 8097 6 B B NNP cord-015021-pol2qm74 8097 7 is be VBZ cord-015021-pol2qm74 8097 8 its -PRON- PRP$ cord-015021-pol2qm74 8097 9 severe severe JJ cord-015021-pol2qm74 8097 10 side side NN cord-015021-pol2qm74 8097 11 - - HYPH cord-015021-pol2qm74 8097 12 effects effect NNS cord-015021-pol2qm74 8097 13 , , , cord-015021-pol2qm74 8097 14 especially especially RB cord-015021-pol2qm74 8097 15 the the DT cord-015021-pol2qm74 8097 16 nephrotoxicity nephrotoxicity NN cord-015021-pol2qm74 8097 17 . . . cord-015021-pol2qm74 8098 1 To to TO cord-015021-pol2qm74 8098 2 decrease decrease VB cord-015021-pol2qm74 8098 3 the the DT cord-015021-pol2qm74 8098 4 toxic toxic JJ cord-015021-pol2qm74 8098 5 side side NN cord-015021-pol2qm74 8098 6 .. .. NFP cord-015021-pol2qm74 8098 7 cffccts cffcct VBZ cord-015021-pol2qm74 8098 8 various various JJ cord-015021-pol2qm74 8098 9 liposomal liposomal JJ cord-015021-pol2qm74 8098 10 amphoteficin amphoteficin NNS cord-015021-pol2qm74 8098 11 B B NNP cord-015021-pol2qm74 8098 12 formulations formulation NNS cord-015021-pol2qm74 8098 13 have have VBP cord-015021-pol2qm74 8098 14 been be VBN cord-015021-pol2qm74 8098 15 produced produce VBN cord-015021-pol2qm74 8098 16 . . . cord-015021-pol2qm74 8099 1 It -PRON- PRP cord-015021-pol2qm74 8099 2 was be VBD cord-015021-pol2qm74 8099 3 found find VBN cord-015021-pol2qm74 8099 4 that that IN cord-015021-pol2qm74 8099 5 these these DT cord-015021-pol2qm74 8099 6 liposemal liposemal VBN cord-015021-pol2qm74 8099 7 formulations formulation NNS cord-015021-pol2qm74 8099 8 were be VBD cord-015021-pol2qm74 8099 9 as as RB cord-015021-pol2qm74 8099 10 effective effective JJ cord-015021-pol2qm74 8099 11 as as IN cord-015021-pol2qm74 8099 12 amphotericin amphotericin NNS cord-015021-pol2qm74 8099 13 B b NN cord-015021-pol2qm74 8099 14 but but CC cord-015021-pol2qm74 8099 15 in in IN cord-015021-pol2qm74 8099 16 contrast contrast NN cord-015021-pol2qm74 8099 17 had have VBD cord-015021-pol2qm74 8099 18 a a DT cord-015021-pol2qm74 8099 19 low low JJ cord-015021-pol2qm74 8099 20 incidence incidence NN cord-015021-pol2qm74 8099 21 of of IN cord-015021-pol2qm74 8099 22 toxicity toxicity NN cord-015021-pol2qm74 8099 23 . . . cord-015021-pol2qm74 8100 1 At at IN cord-015021-pol2qm74 8100 2 present present NN cord-015021-pol2qm74 8100 3 there there EX cord-015021-pol2qm74 8100 4 are be VBP cord-015021-pol2qm74 8100 5 three three CD cord-015021-pol2qm74 8100 6 ~different ~different JJ cord-015021-pol2qm74 8100 7 variations variation NNS cord-015021-pol2qm74 8100 8 of of IN cord-015021-pol2qm74 8100 9 lipid lipid NN cord-015021-pol2qm74 8100 10 formulations formulation NNS cord-015021-pol2qm74 8100 11 under under IN cord-015021-pol2qm74 8100 12 assessment assessment NN cord-015021-pol2qm74 8100 13 : : : cord-015021-pol2qm74 8100 14 Amphotericin Amphotericin NNP cord-015021-pol2qm74 8100 15 B B NNP cord-015021-pol2qm74 8100 16 lipid lipid NN cord-015021-pol2qm74 8100 17 complex complex NN cord-015021-pol2qm74 8100 18 ( ( -LRB- cord-015021-pol2qm74 8100 19 ABLC ABLC NNP cord-015021-pol2qm74 8100 20 ) ) -RRB- cord-015021-pol2qm74 8100 21 , , , cord-015021-pol2qm74 8100 22 amphotericin amphotericin NNS cord-015021-pol2qm74 8100 23 B b NN cord-015021-pol2qm74 8100 24 coloidal coloidal NN cord-015021-pol2qm74 8100 25 dispersion dispersion NN cord-015021-pol2qm74 8100 26 ( ( -LRB- cord-015021-pol2qm74 8100 27 ABCD ABCD NNP cord-015021-pol2qm74 8100 28 ) ) -RRB- cord-015021-pol2qm74 8100 29 or or CC cord-015021-pol2qm74 8100 30 true true JJ cord-015021-pol2qm74 8100 31 liposomes liposome NNS cord-015021-pol2qm74 8100 32 . . . cord-015021-pol2qm74 8101 1 The the DT cord-015021-pol2qm74 8101 2 ABLC ABLC NNP cord-015021-pol2qm74 8101 3 has have VBZ cord-015021-pol2qm74 8101 4 a a DT cord-015021-pol2qm74 8101 5 ribbon ribbon NN cord-015021-pol2qm74 8101 6 like like IN cord-015021-pol2qm74 8101 7 structure structure NN cord-015021-pol2qm74 8101 8 . . . cord-015021-pol2qm74 8102 1 It -PRON- PRP cord-015021-pol2qm74 8102 2 has have VBZ cord-015021-pol2qm74 8102 3 been be VBN cord-015021-pol2qm74 8102 4 shown show VBN cord-015021-pol2qm74 8102 5 to to TO cord-015021-pol2qm74 8102 6 have have VB cord-015021-pol2qm74 8102 7 a a DT cord-015021-pol2qm74 8102 8 reduced reduce VBN cord-015021-pol2qm74 8102 9 toxicity toxicity NN cord-015021-pol2qm74 8102 10 and and CC cord-015021-pol2qm74 8102 11 an an DT cord-015021-pol2qm74 8102 12 efficacy efficacy NN cord-015021-pol2qm74 8102 13 ranging range VBG cord-015021-pol2qm74 8102 14 from from IN cord-015021-pol2qm74 8102 15 being be VBG cord-015021-pol2qm74 8102 16 as as IN cord-015021-pol2qm74 8102 17 effective effective JJ cord-015021-pol2qm74 8102 18 to to IN cord-015021-pol2qm74 8102 19 four four CD cord-015021-pol2qm74 8102 20 times time NNS cord-015021-pol2qm74 8102 21 less less RBR cord-015021-pol2qm74 8102 22 effective effective JJ cord-015021-pol2qm74 8102 23 that that DT cord-015021-pol2qm74 8103 1 conventional conventional JJ cord-015021-pol2qm74 8103 2 amphotericin amphotericin NNS cord-015021-pol2qm74 8103 3 B. B. NNP cord-015021-pol2qm74 8104 1 Regarding regard VBG cord-015021-pol2qm74 8104 2 ABCD ABCD NNP cord-015021-pol2qm74 8105 1 the the DT cord-015021-pol2qm74 8105 2 particles particle NNS cord-015021-pol2qm74 8105 3 have have VBP cord-015021-pol2qm74 8105 4 a a DT cord-015021-pol2qm74 8105 5 disk disk NN cord-015021-pol2qm74 8105 6 - - HYPH cord-015021-pol2qm74 8105 7 like like JJ cord-015021-pol2qm74 8105 8 structure structure NN cord-015021-pol2qm74 8105 9 with with IN cord-015021-pol2qm74 8105 10 a a DT cord-015021-pol2qm74 8105 11 diameter diameter NN cord-015021-pol2qm74 8105 12 of of IN cord-015021-pol2qm74 8105 13 around around RB cord-015021-pol2qm74 8105 14 t00 t00 NN cord-015021-pol2qm74 8105 15 am be VBP cord-015021-pol2qm74 8105 16 and and CC cord-015021-pol2qm74 8105 17 a a DT cord-015021-pol2qm74 8105 18 thickness thickness NN cord-015021-pol2qm74 8105 19 of of IN cord-015021-pol2qm74 8105 20 4 4 CD cord-015021-pol2qm74 8105 21 nm nm NN cord-015021-pol2qm74 8105 22 . . . cord-015021-pol2qm74 8106 1 The the DT cord-015021-pol2qm74 8106 2 ami ami NNP cord-015021-pol2qm74 8106 3 - - HYPH cord-015021-pol2qm74 8106 4 fungal fungal JJ cord-015021-pol2qm74 8106 5 efficacy efficacy NN cord-015021-pol2qm74 8106 6 is be VBZ cord-015021-pol2qm74 8106 7 2 2 CD cord-015021-pol2qm74 8106 8 - - SYM cord-015021-pol2qm74 8106 9 4 4 CD cord-015021-pol2qm74 8106 10 times time NNS cord-015021-pol2qm74 8106 11 less less JJR cord-015021-pol2qm74 8106 12 than than IN cord-015021-pol2qm74 8106 13 that that DT cord-015021-pol2qm74 8106 14 of of IN cord-015021-pol2qm74 8106 15 conventional conventional JJ cord-015021-pol2qm74 8106 16 amphotedcin amphotedcin NNS cord-015021-pol2qm74 8106 17 B. B. NNP cord-015021-pol2qm74 8107 1 Both both DT cord-015021-pol2qm74 8107 2 ABLC ABLC NNP cord-015021-pol2qm74 8107 3 and and CC cord-015021-pol2qm74 8107 4 ABCD ABCD NNP cord-015021-pol2qm74 8107 5 are be VBP cord-015021-pol2qm74 8107 6 presently presently RB cord-015021-pol2qm74 8107 7 investigated investigate VBN cord-015021-pol2qm74 8107 8 in in IN cord-015021-pol2qm74 8107 9 phase phase NN cord-015021-pol2qm74 8107 10 II II NNP cord-015021-pol2qm74 8107 11 / / SYM cord-015021-pol2qm74 8107 12 III iii CD cord-015021-pol2qm74 8107 13 studies study NNS cord-015021-pol2qm74 8107 14 in in IN cord-015021-pol2qm74 8107 15 the the DT cord-015021-pol2qm74 8107 16 US US NNP cord-015021-pol2qm74 8107 17 . . . cord-015021-pol2qm74 8108 1 AmBiseme AmBiseme NNP cord-015021-pol2qm74 8108 2 is be VBZ cord-015021-pol2qm74 8108 3 currently currently RB cord-015021-pol2qm74 8108 4 the the DT cord-015021-pol2qm74 8108 5 only only JJ cord-015021-pol2qm74 8108 6 commefieally commefieally RB cord-015021-pol2qm74 8108 7 available available JJ cord-015021-pol2qm74 8108 8 true true JJ cord-015021-pol2qm74 8108 9 lipesome lipesome NNP cord-015021-pol2qm74 8108 10 . . . cord-015021-pol2qm74 8109 1 AmBiseme AmBiseme NNP cord-015021-pol2qm74 8109 2 is be VBZ cord-015021-pol2qm74 8109 3 a a DT cord-015021-pol2qm74 8109 4 spherical spherical JJ cord-015021-pol2qm74 8109 5 small small JJ cord-015021-pol2qm74 8109 6 unilamellar unilamellar NNP cord-015021-pol2qm74 8109 7 lipesome lipesome NNP cord-015021-pol2qm74 8109 8 with with IN cord-015021-pol2qm74 8109 9 a a DT cord-015021-pol2qm74 8109 10 diameter diameter NN cord-015021-pol2qm74 8109 11 less less JJR cord-015021-pol2qm74 8109 12 than than IN cord-015021-pol2qm74 8109 13 100 100 CD cord-015021-pol2qm74 8109 14 nm nm NN cord-015021-pol2qm74 8109 15 with with IN cord-015021-pol2qm74 8109 16 a a DT cord-015021-pol2qm74 8109 17 mutina mutina JJ cord-015021-pol2qm74 8109 18 LD50 ld50 NN cord-015021-pol2qm74 8109 19 of of IN cord-015021-pol2qm74 8109 20 > > $ cord-015021-pol2qm74 8109 21 175 175 CD cord-015021-pol2qm74 8109 22 mg mg NNP cord-015021-pol2qm74 8109 23 / / SYM cord-015021-pol2qm74 8109 24 kg kg NN cord-015021-pol2qm74 8109 25 . . . cord-015021-pol2qm74 8110 1 It -PRON- PRP cord-015021-pol2qm74 8110 2 has have VBZ cord-015021-pol2qm74 8110 3 been be VBN cord-015021-pol2qm74 8110 4 used use VBN cord-015021-pol2qm74 8110 5 in in IN cord-015021-pol2qm74 8110 6 dosages dosage NNS cord-015021-pol2qm74 8110 7 up up IN cord-015021-pol2qm74 8110 8 to to TO cord-015021-pol2qm74 8110 9 6 6 CD cord-015021-pol2qm74 8110 10 mg mg NN cord-015021-pol2qm74 8110 11 / / SYM cord-015021-pol2qm74 8110 12 kg kg NNP cord-015021-pol2qm74 8110 13 / / SYM cord-015021-pol2qm74 8110 14 day day NN cord-015021-pol2qm74 8110 15 in in IN cord-015021-pol2qm74 8110 16 compassionate compassionate JJ cord-015021-pol2qm74 8110 17 based base VBN cord-015021-pol2qm74 8110 18 studies study NNS cord-015021-pol2qm74 8110 19 with with IN cord-015021-pol2qm74 8110 20 good good JJ cord-015021-pol2qm74 8110 21 tolerability tolerability NN cord-015021-pol2qm74 8110 22 . . . cord-015021-pol2qm74 8111 1 The the DT cord-015021-pol2qm74 8111 2 mycological mycological JJ cord-015021-pol2qm74 8111 3 efficacy efficacy NN cord-015021-pol2qm74 8111 4 range range NN cord-015021-pol2qm74 8111 5 from from IN cord-015021-pol2qm74 8111 6 a a DT cord-015021-pol2qm74 8111 7 83 83 CD cord-015021-pol2qm74 8111 8 % % NN cord-015021-pol2qm74 8111 9 response response NN cord-015021-pol2qm74 8111 10 rate rate NN cord-015021-pol2qm74 8111 11 for for IN cord-015021-pol2qm74 8111 12 invasive invasive JJ cord-015021-pol2qm74 8111 13 Candida Candida NNP cord-015021-pol2qm74 8111 14 infections infection NNS cord-015021-pol2qm74 8111 15 to to IN cord-015021-pol2qm74 8111 16 41 41 CD cord-015021-pol2qm74 8111 17 % % NN cord-015021-pol2qm74 8111 18 response response NN cord-015021-pol2qm74 8111 19 rate rate NN cord-015021-pol2qm74 8111 20 for for IN cord-015021-pol2qm74 8111 21 Aspergillosis Aspergillosis NNP cord-015021-pol2qm74 8111 22 . . . cord-015021-pol2qm74 8112 1 AmBisomc AmBisomc NNP cord-015021-pol2qm74 8112 2 have have VBP cord-015021-pol2qm74 8112 3 been be VBN cord-015021-pol2qm74 8112 4 evaluated evaluate VBN cord-015021-pol2qm74 8112 5 as as IN cord-015021-pol2qm74 8112 6 anti anti JJ cord-015021-pol2qm74 8112 7 - - JJ cord-015021-pol2qm74 8112 8 fungal fungal JJ cord-015021-pol2qm74 8112 9 prophylaxis prophylaxis NN cord-015021-pol2qm74 8112 10 in in IN cord-015021-pol2qm74 8112 11 randomized randomized JJ cord-015021-pol2qm74 8112 12 trials trial NNS cord-015021-pol2qm74 8112 13 in in IN cord-015021-pol2qm74 8112 14 bone bone NN cord-015021-pol2qm74 8112 15 marrow marrow NN cord-015021-pol2qm74 8112 16 ( ( -LRB- cord-015021-pol2qm74 8112 17 BMT BMT NNP cord-015021-pol2qm74 8112 18 ) ) -RRB- cord-015021-pol2qm74 8112 19 and and CC cord-015021-pol2qm74 8112 20 liver liver NN cord-015021-pol2qm74 8112 21 transplant transplant NN cord-015021-pol2qm74 8112 22 ( ( -LRB- cord-015021-pol2qm74 8112 23 LTX LTX NNP cord-015021-pol2qm74 8112 24 ) ) -RRB- cord-015021-pol2qm74 8112 25 recipients recipient NNS cord-015021-pol2qm74 8112 26 . . . cord-015021-pol2qm74 8113 1 It -PRON- PRP cord-015021-pol2qm74 8113 2 was be VBD cord-015021-pol2qm74 8113 3 well well RB cord-015021-pol2qm74 8113 4 tolerated tolerate VBN cord-015021-pol2qm74 8113 5 . . . cord-015021-pol2qm74 8114 1 In in IN cord-015021-pol2qm74 8114 2 BMT BMT NNP cord-015021-pol2qm74 8114 3 recipients recipient NNS cord-015021-pol2qm74 8114 4 the the DT cord-015021-pol2qm74 8114 5 incidence incidence NN cord-015021-pol2qm74 8114 6 of of IN cord-015021-pol2qm74 8114 7 proven prove VBN cord-015021-pol2qm74 8114 8 fungal fungal JJ cord-015021-pol2qm74 8114 9 infections infection NNS cord-015021-pol2qm74 8114 10 was be VBD cord-015021-pol2qm74 8114 11 8 8 CD cord-015021-pol2qm74 8114 12 % % NN cord-015021-pol2qm74 8114 13 among among IN cord-015021-pol2qm74 8114 14 placebo placebo NN cord-015021-pol2qm74 8114 15 treated treat VBN cord-015021-pol2qm74 8114 16 patients patient NNS cord-015021-pol2qm74 8114 17 compared compare VBN cord-015021-pol2qm74 8114 18 to to IN cord-015021-pol2qm74 8114 19 3 3 CD cord-015021-pol2qm74 8114 20 % % NN cord-015021-pol2qm74 8114 21 for for IN cord-015021-pol2qm74 8114 22 the the DT cord-015021-pol2qm74 8114 23 AmBisome AmBisome NNP cord-015021-pol2qm74 8114 24 treated treat VBN cord-015021-pol2qm74 8114 25 patients patient NNS cord-015021-pol2qm74 8114 26 ( ( -LRB- cord-015021-pol2qm74 8114 27 ns ns IN cord-015021-pol2qm74 8114 28 ) ) -RRB- cord-015021-pol2qm74 8114 29 . . . cord-015021-pol2qm74 8115 1 In in IN cord-015021-pol2qm74 8115 2 LTX LTX NNP cord-015021-pol2qm74 8115 3 recipients recipient NNS cord-015021-pol2qm74 8115 4 AmBisome AmBisome NNP cord-015021-pol2qm74 8115 5 prophylaxis prophylaxis NN cord-015021-pol2qm74 8115 6 was be VBD cord-015021-pol2qm74 8115 7 effective effective JJ cord-015021-pol2qm74 8115 8 , , , cord-015021-pol2qm74 8115 9 significantly significantly RB cord-015021-pol2qm74 8115 10 reducing reduce VBG cord-015021-pol2qm74 8115 11 the the DT cord-015021-pol2qm74 8115 12 incidence incidence NN cord-015021-pol2qm74 8115 13 of of IN cord-015021-pol2qm74 8115 14 deep deep JJ cord-015021-pol2qm74 8115 15 fungal fungal JJ cord-015021-pol2qm74 8115 16 infections infection NNS cord-015021-pol2qm74 8115 17 from from IN cord-015021-pol2qm74 8115 18 16 16 CD cord-015021-pol2qm74 8115 19 % % NN cord-015021-pol2qm74 8115 20 to to IN cord-015021-pol2qm74 8115 21 0 0 CD cord-015021-pol2qm74 8115 22 % % NN cord-015021-pol2qm74 8115 23 ill ill JJ cord-015021-pol2qm74 8115 24 placebo placebo NN cord-015021-pol2qm74 8115 25 and and CC cord-015021-pol2qm74 8115 26 AmBisome ambisome NN cord-015021-pol2qm74 8115 27 treated treat VBD cord-015021-pol2qm74 8115 28 patients patient NNS cord-015021-pol2qm74 8115 29 respectively respectively RB cord-015021-pol2qm74 8115 30 ( ( -LRB- cord-015021-pol2qm74 8115 31 p<0.01 p<0.01 NNP cord-015021-pol2qm74 8115 32 ) ) -RRB- cord-015021-pol2qm74 8115 33 . . . cord-015021-pol2qm74 8116 1 Prospective prospective JJ cord-015021-pol2qm74 8116 2 randomized randomized JJ cord-015021-pol2qm74 8116 3 trials trial NNS cord-015021-pol2qm74 8116 4 comparing compare VBG cord-015021-pol2qm74 8116 5 these these DT cord-015021-pol2qm74 8116 6 various various JJ cord-015021-pol2qm74 8116 7 amphotericin amphotericin NNS cord-015021-pol2qm74 8116 8 B b NN cord-015021-pol2qm74 8116 9 preparations preparation NNS cord-015021-pol2qm74 8116 10 with with IN cord-015021-pol2qm74 8116 11 conventional conventional JJ cord-015021-pol2qm74 8116 12 amphotericin amphotericin NNS cord-015021-pol2qm74 8116 13 B B NNP cord-015021-pol2qm74 8116 14 is be VBZ cord-015021-pol2qm74 8116 15 needed need VBN cord-015021-pol2qm74 8116 16 to to TO cord-015021-pol2qm74 8116 17 determine determine VB cord-015021-pol2qm74 8116 18 their -PRON- PRP$ cord-015021-pol2qm74 8116 19 future future JJ cord-015021-pol2qm74 8116 20 place place NN cord-015021-pol2qm74 8116 21 in in IN cord-015021-pol2qm74 8116 22 the the DT cord-015021-pol2qm74 8116 23 therapeutical therapeutical JJ cord-015021-pol2qm74 8116 24 arsenal arsenal NN cord-015021-pol2qm74 8116 25 . . . cord-015021-pol2qm74 8117 1 Two two CD cord-015021-pol2qm74 8117 2 patlentgroups patlentgroup NNS cord-015021-pol2qm74 8117 3 ere ere VBP cord-015021-pol2qm74 8117 4 particularly particularly RB cord-015021-pol2qm74 8117 5 at at IN cord-015021-pol2qm74 8117 6 risk risk NN cord-015021-pol2qm74 8117 7 to to TO cord-015021-pol2qm74 8117 8 develop develop VB cord-015021-pol2qm74 8117 9 serious serious JJ cord-015021-pol2qm74 8117 10 CMV CMV NNP cord-015021-pol2qm74 8117 11 disease disease NN cord-015021-pol2qm74 8117 12 : : : cord-015021-pol2qm74 8118 1 CMV CMV NNP cord-015021-pol2qm74 8118 2 seronegative seronegative JJ cord-015021-pol2qm74 8118 3 transplant transplant NN cord-015021-pol2qm74 8118 4 recipients recipient NNS cord-015021-pol2qm74 8118 5 of of IN cord-015021-pol2qm74 8118 6 seroposltlva seroposltlva JJ cord-015021-pol2qm74 8118 7 donors donor NNS cord-015021-pol2qm74 8118 8 and and CC cord-015021-pol2qm74 8118 9 those those DT cord-015021-pol2qm74 8118 10 patlants patlant NNS cord-015021-pol2qm74 8118 11 treated treat VBN cord-015021-pol2qm74 8118 12 for for IN cord-015021-pol2qm74 8118 13 rejection rejection NN cord-015021-pol2qm74 8118 14 with with IN cord-015021-pol2qm74 8118 15 anti anti NNP cord-015021-pol2qm74 8118 16 T T NNP cord-015021-pol2qm74 8118 17 - - HYPH cord-015021-pol2qm74 8118 18 ceil ceil NN cord-015021-pol2qm74 8118 19 preparations preparation NNS cord-015021-pol2qm74 8118 20 , , , cord-015021-pol2qm74 8118 21 We -PRON- PRP cord-015021-pol2qm74 8118 22 have have VBP cord-015021-pol2qm74 8118 23 evaluated evaluate VBN cord-015021-pol2qm74 8118 24 the the DT cord-015021-pol2qm74 8118 25 value value NN cord-015021-pol2qm74 8118 26 of of IN cord-015021-pol2qm74 8118 27 prophylactic prophylactic JJ cord-015021-pol2qm74 8118 28 anti anti JJ cord-015021-pol2qm74 8118 29 - - JJ cord-015021-pol2qm74 8118 30 CMV CMV NNP cord-015021-pol2qm74 8118 31 immunoglobulin immunoglobulin NN cord-015021-pol2qm74 8118 32 ( ( -LRB- cord-015021-pol2qm74 8118 33 Cytotect Cytotect NNP cord-015021-pol2qm74 8118 34 " " '' cord-015021-pol2qm74 8118 35 , , , cord-015021-pol2qm74 8118 36 Biotest Biotest NNP cord-015021-pol2qm74 8118 37 Pbarma Pbarma NNP cord-015021-pol2qm74 8118 38 GmbH GmbH NNP cord-015021-pol2qm74 8118 39 , , , cord-015021-pol2qm74 8118 40 Dreieich Dreieich NNP cord-015021-pol2qm74 8118 41 , , , cord-015021-pol2qm74 8118 42 FRG FRG NNP cord-015021-pol2qm74 8118 43 ) ) -RRB- cord-015021-pol2qm74 8118 44 administration administration NN cord-015021-pol2qm74 8118 45 in in IN cord-015021-pol2qm74 8118 46 high high JJ cord-015021-pol2qm74 8118 47 risk risk NN cord-015021-pol2qm74 8118 48 heart heart NN cord-015021-pol2qm74 8118 49 and and CC cord-015021-pol2qm74 8118 50 kidney kidney NN cord-015021-pol2qm74 8118 51 transplant transplant NN cord-015021-pol2qm74 8118 52 recipients recipient NNS cord-015021-pol2qm74 8118 53 , , , cord-015021-pol2qm74 8118 54 In in IN cord-015021-pol2qm74 8118 55 a a DT cord-015021-pol2qm74 8118 56 double double JJ cord-015021-pol2qm74 8118 57 blind blind JJ cord-015021-pol2qm74 8118 58 placebo placebo NN cord-015021-pol2qm74 8118 59 Controlled Controlled NNP cord-015021-pol2qm74 8118 60 study study NN cord-015021-pol2qm74 8118 61 40 40 CD cord-015021-pol2qm74 8118 62 kidney kidney NN cord-015021-pol2qm74 8118 63 transplant transplant NN cord-015021-pol2qm74 8118 64 recipients recipient NNS cord-015021-pol2qm74 8118 65 , , , cord-015021-pol2qm74 8118 66 treated treat VBN cord-015021-pol2qm74 8118 67 for for IN cord-015021-pol2qm74 8118 68 biopsy biopsy NN cord-015021-pol2qm74 8118 69 proved prove VBD cord-015021-pol2qm74 8118 70 re)action re)action NN cord-015021-pol2qm74 8118 71 with with IN cord-015021-pol2qm74 8118 72 rabbit rabbit NN cord-015021-pol2qm74 8118 73 ATG ATG NNP cord-015021-pol2qm74 8118 74 , , , cord-015021-pol2qm74 8118 75 received receive VBD cord-015021-pol2qm74 8118 76 globullntplacebo globullntplacebo NNP cord-015021-pol2qm74 8118 77 Infusions infusion NNS cord-015021-pol2qm74 8118 78 . . . cord-015021-pol2qm74 8119 1 The the DT cord-015021-pol2qm74 8119 2 preparatlons preparatlon NNS cord-015021-pol2qm74 8119 3 were be VBD cord-015021-pol2qm74 8119 4 given give VBN cord-015021-pol2qm74 8119 5 I -PRON- PRP cord-015021-pol2qm74 8119 6 , , , cord-015021-pol2qm74 8119 7 v v NN cord-015021-pol2qm74 8119 8 , , , cord-015021-pol2qm74 8119 9 In in IN cord-015021-pol2qm74 8119 10 a a DT cord-015021-pol2qm74 8119 11 dose dose NN cord-015021-pol2qm74 8119 12 of of IN cord-015021-pol2qm74 8119 13 100 100 CD cord-015021-pol2qm74 8119 14 mg mg NNP cord-015021-pol2qm74 8119 15 / / SYM cord-015021-pol2qm74 8119 16 kg kg NNP cord-015021-pol2qm74 8119 17 at at IN cord-015021-pol2qm74 8119 18 day day NN cord-015021-pol2qm74 8119 19 0,7,14,35,56 0,7,14,35,56 NN cord-015021-pol2qm74 8119 20 and and CC cord-015021-pol2qm74 8119 21 77 77 CD cord-015021-pol2qm74 8119 22 after after IN cord-015021-pol2qm74 8119 23 the the DT cord-015021-pol2qm74 8119 24 Initiation Initiation NNP cord-015021-pol2qm74 8119 25 of of IN cord-015021-pol2qm74 8119 26 anti anti JJ cord-015021-pol2qm74 8119 27 = = NN cord-015021-pol2qm74 8119 28 rejection rejection NN cord-015021-pol2qm74 8119 29 therapy therapy NN cord-015021-pol2qm74 8119 30 , , , cord-015021-pol2qm74 8119 31 Passive passive JJ cord-015021-pol2qm74 8119 32 immunization immunization NN cord-015021-pol2qm74 8119 33 completely completely RB cord-015021-pol2qm74 8119 34 prevented prevent VBD cord-015021-pol2qm74 8119 35 CMV CMV NNP cord-015021-pol2qm74 8119 36 related relate VBN cord-015021-pol2qm74 8119 37 death death NN cord-015021-pol2qm74 8119 38 , , , cord-015021-pol2qm74 8119 39 although although IN cord-015021-pol2qm74 8119 40 it -PRON- PRP cord-015021-pol2qm74 8119 41 did do VBD cord-015021-pol2qm74 8119 42 not not RB cord-015021-pol2qm74 8119 43 reduce reduce VB cord-015021-pol2qm74 8119 44 th~ th~ NN cord-015021-pol2qm74 8119 45 incidence incidence NN cord-015021-pol2qm74 8119 46 of of IN cord-015021-pol2qm74 8119 47 CMV CMV NNP cord-015021-pol2qm74 8119 48 isolation isolation NN cord-015021-pol2qm74 8119 49 , , , cord-015021-pol2qm74 8119 50 viraemia viraemia NN cord-015021-pol2qm74 8119 51 or or CC cord-015021-pol2qm74 8119 52 disease disease NN cord-015021-pol2qm74 8119 53 , , , cord-015021-pol2qm74 8119 54 This this DT cord-015021-pol2qm74 8119 55 effect effect NN cord-015021-pol2qm74 8119 56 was be VBD cord-015021-pol2qm74 8119 57 mainly mainly RB cord-015021-pol2qm74 8119 58 observed observe VBN cord-015021-pol2qm74 8119 59 in in IN cord-015021-pol2qm74 8119 60 CMV CMV NNP cord-015021-pol2qm74 8119 61 saronegativa saronegativa NN cord-015021-pol2qm74 8119 62 recipients recipient NNS cord-015021-pol2qm74 8119 63 of of IN cord-015021-pol2qm74 8119 64 a a DT cord-015021-pol2qm74 8119 65 serop0sitive serop0sitive NNP cord-015021-pol2qm74 8119 66 donorktdney donorktdney NN cord-015021-pol2qm74 8119 67 . . . cord-015021-pol2qm74 8120 1 Seroposltive seroposltive JJ cord-015021-pol2qm74 8120 2 recipients recipient NNS cord-015021-pol2qm74 8120 3 did do VBD cord-015021-pol2qm74 8120 4 not not RB cord-015021-pol2qm74 8120 5 benefit benefit VB cord-015021-pol2qm74 8120 6 from from IN cord-015021-pol2qm74 8120 7 treatment treatment NN cord-015021-pol2qm74 8120 8 and and CC cord-015021-pol2qm74 8120 9 seronegatlve seronegatlve NN cord-015021-pol2qm74 8120 10 recipients recipient NNS cord-015021-pol2qm74 8120 11 of of IN cord-015021-pol2qm74 8120 12 a a DT cord-015021-pol2qm74 8120 13 seronegetlye seronegetlye JJ cord-015021-pol2qm74 8120 14 donor donor NN cord-015021-pol2qm74 8120 15 were be VBD cord-015021-pol2qm74 8120 16 not not RB cord-015021-pol2qm74 8120 17 et et FW cord-015021-pol2qm74 8120 18 risk risk NN cord-015021-pol2qm74 8120 19 for for IN cord-015021-pol2qm74 8120 20 CMV CMV NNP cord-015021-pol2qm74 8120 21 infection infection NN cord-015021-pol2qm74 8120 22 at at IN cord-015021-pol2qm74 8120 23 e!l e!l NNP cord-015021-pol2qm74 8120 24 . . . cord-015021-pol2qm74 8121 1 In in IN cord-015021-pol2qm74 8121 2 a a DT cord-015021-pol2qm74 8121 3 open open JJ cord-015021-pol2qm74 8121 4 study study NN cord-015021-pol2qm74 8121 5 the the DT cord-015021-pol2qm74 8121 6 incidence incidence NN cord-015021-pol2qm74 8121 7 of of IN cord-015021-pol2qm74 8121 8 CMV CMV NNP cord-015021-pol2qm74 8121 9 Infection Infection NNP cord-015021-pol2qm74 8121 10 and and CC cord-015021-pol2qm74 8121 11 disease disease NN cord-015021-pol2qm74 8121 12 was be VBD cord-015021-pol2qm74 8121 13 evaluated evaluate VBN cord-015021-pol2qm74 8121 14 In in IN cord-015021-pol2qm74 8121 15 143 143 CD cord-015021-pol2qm74 8121 16 consecutive consecutive JJ cord-015021-pol2qm74 8121 17 I I NNP cord-015021-pol2qm74 8121 18 ~ ~ CD cord-015021-pol2qm74 8121 19 eart eart NNP cord-015021-pol2qm74 8121 20 sllograft sllograft NNP cord-015021-pol2qm74 8121 21 recipients recipient NNS cord-015021-pol2qm74 8121 22 . . . cord-015021-pol2qm74 8122 1 Sixty sixty CD cord-015021-pol2qm74 8122 2 - - HYPH cord-015021-pol2qm74 8122 3 five five CD cord-015021-pol2qm74 8122 4 patients patient NNS cord-015021-pol2qm74 8122 5 were be VBD cord-015021-pol2qm74 8122 6 CMV CMV NNP cord-015021-pol2qm74 8122 7 seronagatlve seronagatlve NN cord-015021-pol2qm74 8122 8 and and CC cord-015021-pol2qm74 8123 1 they -PRON- PRP cord-015021-pol2qm74 8123 2 all all DT cord-015021-pol2qm74 8123 3 received receive VBD cord-015021-pol2qm74 8123 4 passive passive JJ cord-015021-pol2qm74 8123 5 immunlzation immunlzation NN cord-015021-pol2qm74 8123 6 according accord VBG cord-015021-pol2qm74 8123 7 to to IN cord-015021-pol2qm74 8123 8 the the DT cord-015021-pol2qm74 8123 9 dosage dosage NN cord-015021-pol2qm74 8123 10 schedule schedule NN cord-015021-pol2qm74 8123 11 used use VBN cord-015021-pol2qm74 8123 12 in in IN cord-015021-pol2qm74 8123 13 the the DT cord-015021-pol2qm74 8123 14 kidney kidney NN cord-015021-pol2qm74 8123 15 patients patient NNS cord-015021-pol2qm74 8123 16 , , , cord-015021-pol2qm74 8123 17 but but CC cord-015021-pol2qm74 8123 18 starting start VBG cord-015021-pol2qm74 8123 19 on on IN cord-015021-pol2qm74 8123 20 the the DT cord-015021-pol2qm74 8123 21 day day NN cord-015021-pol2qm74 8123 22 of of IN cord-015021-pol2qm74 8123 23 transplantation transplantation NN cord-015021-pol2qm74 8123 24 , , , cord-015021-pol2qm74 8123 25 This this DT cord-015021-pol2qm74 8123 26 scheme scheme NN cord-015021-pol2qm74 8123 27 resulted result VBD cord-015021-pol2qm74 8123 28 in in IN cord-015021-pol2qm74 8123 29 median median JJ cord-015021-pol2qm74 8123 30 sntI snti JJ cord-015021-pol2qm74 8123 31 - - HYPH cord-015021-pol2qm74 8123 32 CMV CMV NNP cord-015021-pol2qm74 8123 33 IgG igg NN cord-015021-pol2qm74 8123 34 titers titer NNS cord-015021-pol2qm74 8123 35 of of IN cord-015021-pol2qm74 8123 36 1200 1200 CD cord-015021-pol2qm74 8123 37 ELISA ELISA NNP cord-015021-pol2qm74 8123 38 units unit NNS cord-015021-pol2qm74 8123 39 during during IN cord-015021-pol2qm74 8123 40 3 3 CD cord-015021-pol2qm74 8123 41 months month NNS cord-015021-pol2qm74 8123 42 . . . cord-015021-pol2qm74 8124 1 CMV CMV NNP cord-015021-pol2qm74 8124 2 infection infection NN cord-015021-pol2qm74 8124 3 occurred occur VBD cord-015021-pol2qm74 8124 4 in in IN cord-015021-pol2qm74 8124 5 21/65 21/65 CD cord-015021-pol2qm74 8124 6 ~eronegetlve ~eronegetlve XX cord-015021-pol2qm74 8124 7 and and CC cord-015021-pol2qm74 8124 8 in in IN cord-015021-pol2qm74 8124 9 40/81 40/81 CD cord-015021-pol2qm74 8124 10 seropositive seropositive JJ cord-015021-pol2qm74 8124 11 recipients recipient NNS cord-015021-pol2qm74 8124 12 ( ( -LRB- cord-015021-pol2qm74 8124 13 n n NNP cord-015021-pol2qm74 8124 14 , , , cord-015021-pol2qm74 8124 15 s s NNP cord-015021-pol2qm74 8124 16 , , , cord-015021-pol2qm74 8124 17 ) ) -RRB- cord-015021-pol2qm74 8124 18 , , . cord-015021-pol2qm74 8125 1 In in IN cord-015021-pol2qm74 8125 2 ssronegetive ssronegetive JJ cord-015021-pol2qm74 8125 3 donor donor NN cord-015021-pol2qm74 8125 4 - - HYPH cord-015021-pol2qm74 8125 5 recipients recipient NNS cord-015021-pol2qm74 8125 6 pairs pair NNS cord-015021-pol2qm74 8125 7 the the DT cord-015021-pol2qm74 8125 8 incidence incidence NN cord-015021-pol2qm74 8125 9 was be VBD cord-015021-pol2qm74 8125 10 significantly significantly RB cord-015021-pol2qm74 8125 11 lower low JJR cord-015021-pol2qm74 8126 1 ( ( -LRB- cord-015021-pol2qm74 8126 2 3/34 3/34 CD cord-015021-pol2qm74 8126 3 ] ] -RRB- cord-015021-pol2qm74 8126 4 , , , cord-015021-pol2qm74 8126 5 The the DT cord-015021-pol2qm74 8126 6 passively passively RB cord-015021-pol2qm74 8126 7 Immunized immunize VBN cord-015021-pol2qm74 8126 8 seronegstive seronegstive JJ cord-015021-pol2qm74 8126 9 recipients recipient NNS cord-015021-pol2qm74 8126 10 of of IN cord-015021-pol2qm74 8126 11 e e NNP cord-015021-pol2qm74 8126 12 seroposltlve seroposltlve NNP cord-015021-pol2qm74 8126 13 donorheart donorheart NNP cord-015021-pol2qm74 8126 14 showed show VBD cord-015021-pol2qm74 8126 15 comparable comparable JJ cord-015021-pol2qm74 8126 16 incidence incidence NN cord-015021-pol2qm74 8126 17 of of IN cord-015021-pol2qm74 8126 18 CMV CMV NNP cord-015021-pol2qm74 8126 19 infection infection NN cord-015021-pol2qm74 8126 20 f18t29 f18t29 NNP cord-015021-pol2qm74 8126 21 ) ) -RRB- cord-015021-pol2qm74 8126 22 vs vs IN cord-015021-pol2qm74 8126 23 the the DT cord-015021-pol2qm74 8126 24 seropositive seropositive JJ cord-015021-pol2qm74 8126 25 recipients recipient NNS cord-015021-pol2qm74 8126 26 . . . cord-015021-pol2qm74 8127 1 Primary primary JJ cord-015021-pol2qm74 8127 2 infection infection NN cord-015021-pol2qm74 8127 3 more more RBR cord-015021-pol2qm74 8127 4 often often RB cord-015021-pol2qm74 8127 5 resulted result VBN cord-015021-pol2qm74 8127 6 in in IN cord-015021-pol2qm74 8127 7 disease disease NN cord-015021-pol2qm74 8127 8 than than IN cord-015021-pol2qm74 8127 9 secondary secondary JJ cord-015021-pol2qm74 8127 10 infection infection NN cord-015021-pol2qm74 8127 11 ( ( -LRB- cord-015021-pol2qm74 8127 12 11121 11121 CD cord-015021-pol2qm74 8127 13 v8 v8 NNP cord-015021-pol2qm74 8127 14 10/40 10/40 NNP cord-015021-pol2qm74 8127 15 ) ) -RRB- cord-015021-pol2qm74 8127 16 , , , cord-015021-pol2qm74 8127 17 but but CC cord-015021-pol2qm74 8127 18 no no DT cord-015021-pol2qm74 8127 19 difference difference NN cord-015021-pol2qm74 8127 20 in in IN cord-015021-pol2qm74 8127 21 incidence incidence NN cord-015021-pol2qm74 8127 22 of of IN cord-015021-pol2qm74 8127 23 disease disease NN cord-015021-pol2qm74 8127 24 ( ( -LRB- cord-015021-pol2qm74 8127 25 11165 11165 CD cord-015021-pol2qm74 8127 26 vs vs IN cord-015021-pol2qm74 8127 27 10/81 10/81 CD cord-015021-pol2qm74 8127 28 ) ) -RRB- cord-015021-pol2qm74 8127 29 or or CC cord-015021-pol2qm74 8127 30 severity severity NN cord-015021-pol2qm74 8127 31 in in IN cord-015021-pol2qm74 8127 32 symptoms symptom NNS cord-015021-pol2qm74 8127 33 was be VBD cord-015021-pol2qm74 8127 34 noted note VBN cord-015021-pol2qm74 8127 35 between between IN cord-015021-pol2qm74 8127 36 the the DT cord-015021-pol2qm74 8127 37 Immunoglobulln Immunoglobulln NNP cord-015021-pol2qm74 8127 38 treated treat VBD cord-015021-pol2qm74 8127 39 serone(]ative serone(]ative NNP cord-015021-pol2qm74 8127 40 patients patient NNS cord-015021-pol2qm74 8127 41 and and CC cord-015021-pol2qm74 8127 42 the the DT cord-015021-pol2qm74 8127 43 seropositiva seropositiva NNP cord-015021-pol2qm74 8127 44 recipients recipient NNS cord-015021-pol2qm74 8127 45 . . . cord-015021-pol2qm74 8128 1 Apparently apparently RB cord-015021-pol2qm74 8128 2 passive passive JJ cord-015021-pol2qm74 8128 3 immunization immunization NN cord-015021-pol2qm74 8128 4 induces induce VBZ cord-015021-pol2qm74 8128 5 anti anti JJ cord-015021-pol2qm74 8128 6 - - JJ cord-015021-pol2qm74 8128 7 CMV CMV NNP cord-015021-pol2qm74 8128 8 immunity immunity NN cord-015021-pol2qm74 8128 9 which which WDT cord-015021-pol2qm74 8128 10 crossly crossly RB cord-015021-pol2qm74 8128 11 resembles resemble VBZ cord-015021-pol2qm74 8128 12 naturally naturally RB cord-015021-pol2qm74 8128 13 acquired acquire VBN cord-015021-pol2qm74 8128 14 resistance resistance NN cord-015021-pol2qm74 8128 15 . . . cord-015021-pol2qm74 8129 1 Abdulkadirov Abdulkadirov NNP cord-015021-pol2qm74 8129 2 K.,Chebotkevich K.,Chebotkevich NNP cord-015021-pol2qm74 8129 3 V. V. NNP cord-015021-pol2qm74 8129 4 , , , cord-015021-pol2qm74 8129 5 Moiseev Moiseev NNP cord-015021-pol2qm74 8129 6 S. S. NNP cord-015021-pol2qm74 8130 1 The the DT cord-015021-pol2qm74 8130 2 incidence incidence NN cord-015021-pol2qm74 8130 3 of of IN cord-015021-pol2qm74 8130 4 infection infection NN cord-015021-pol2qm74 8130 5 is be VBZ cord-015021-pol2qm74 8130 6 still still RB cord-015021-pol2qm74 8130 7 high high JJ cord-015021-pol2qm74 8130 8 in in IN cord-015021-pol2qm74 8130 9 patients patient NNS cord-015021-pol2qm74 8130 10 underwent undergo VBD cord-015021-pol2qm74 8130 11 BMT BMT NNP cord-015021-pol2qm74 8130 12 . . . cord-015021-pol2qm74 8131 1 This this DT cord-015021-pol2qm74 8131 2 complication complication NN cord-015021-pol2qm74 8131 3 is be VBZ cord-015021-pol2qm74 8131 4 the the DT cord-015021-pol2qm74 8131 5 major major JJ cord-015021-pol2qm74 8131 6 cause cause NN cord-015021-pol2qm74 8131 7 of of IN cord-015021-pol2qm74 8131 8 mortality mortality NN cord-015021-pol2qm74 8131 9 if if IN cord-015021-pol2qm74 8131 10 it -PRON- PRP cord-015021-pol2qm74 8131 11 is be VBZ cord-015021-pol2qm74 8131 12 not not RB cord-015021-pol2qm74 8131 13 recognized recognize VBN cord-015021-pol2qm74 8131 14 and and CC cord-015021-pol2qm74 8131 15 treated treat VBN cord-015021-pol2qm74 8131 16 promptly promptly RB cord-015021-pol2qm74 8131 17 and and CC cord-015021-pol2qm74 8131 18 properly properly RB cord-015021-pol2qm74 8131 19 . . . cord-015021-pol2qm74 8132 1 Our -PRON- PRP$ cord-015021-pol2qm74 8132 2 data datum NNS cord-015021-pol2qm74 8132 3 showed show VBD cord-015021-pol2qm74 8132 4 that that IN cord-015021-pol2qm74 8132 5 from from IN cord-015021-pol2qm74 8132 6 21 21 CD cord-015021-pol2qm74 8132 7 patients patient NNS cord-015021-pol2qm74 8132 8 with with IN cord-015021-pol2qm74 8132 9 different different JJ cord-015021-pol2qm74 8132 10 types type NNS cord-015021-pol2qm74 8132 11 of of IN cord-015021-pol2qm74 8132 12 leucemia leucemia NN cord-015021-pol2qm74 8132 13 after after IN cord-015021-pol2qm74 8132 14 autologous autologous JJ cord-015021-pol2qm74 8132 15 and and CC cord-015021-pol2qm74 8132 16 allogenzc allogenzc VBD cord-015021-pol2qm74 8132 17 BMT BMT NNP cord-015021-pol2qm74 8132 18 19 19 CD cord-015021-pol2qm74 8132 19 had have VBD cord-015021-pol2qm74 8132 20 the the DT cord-015021-pol2qm74 8132 21 episodes episode NNS cord-015021-pol2qm74 8132 22 of of IN cord-015021-pol2qm74 8132 23 fever fever NN cord-015021-pol2qm74 8132 24 . . . cord-015021-pol2qm74 8133 1 In in IN cord-015021-pol2qm74 8133 2 the the DT cord-015021-pol2qm74 8133 3 ma ma NNP cord-015021-pol2qm74 8133 4 i i NNP cord-015021-pol2qm74 8133 5 ority ority NN cord-015021-pol2qm74 8133 6 of of IN cord-015021-pol2qm74 8133 7 these these DT cord-015021-pol2qm74 8133 8 episodes episode NNS cord-015021-pol2qm74 8133 9 the the DT cord-015021-pol2qm74 8133 10 bacterial bacterial JJ cord-015021-pol2qm74 8133 11 etiolog$ etiolog$ NNP cord-015021-pol2qm74 8133 12 gram gram NNP cord-015021-pol2qm74 8133 13 negative negative JJ cord-015021-pol2qm74 8133 14 bacflli bacflli NN cord-015021-pol2qm74 8133 15 and and CC cord-015021-pol2qm74 8133 16 gram gram VB cord-015021-pol2qm74 8133 17 positive positive JJ cord-015021-pol2qm74 8133 18 cocci coccus NNS cord-015021-pol2qm74 8133 19 ) ) -RRB- cord-015021-pol2qm74 8133 20 can can MD cord-015021-pol2qm74 8133 21 be be VB cord-015021-pol2qm74 8133 22 proved prove VBN cord-015021-pol2qm74 8133 23 . . . cord-015021-pol2qm74 8134 1 On on IN cord-015021-pol2qm74 8134 2 the the DT cord-015021-pol2qm74 8134 3 other other JJ cord-015021-pol2qm74 8134 4 hand hand NN cord-015021-pol2qm74 8134 5 , , , cord-015021-pol2qm74 8134 6 in in IN cord-015021-pol2qm74 8134 7 62 62 CD cord-015021-pol2qm74 8134 8 % % NN cord-015021-pol2qm74 8134 9 of of IN cord-015021-pol2qm74 8134 10 the the DT cord-015021-pol2qm74 8134 11 fever fever NN cord-015021-pol2qm74 8134 12 cases case NNS cord-015021-pol2qm74 8134 13 we -PRON- PRP cord-015021-pol2qm74 8134 14 detected detect VBD cord-015021-pol2qm74 8134 15 also also RB cord-015021-pol2qm74 8134 16 viral viral JJ cord-015021-pol2qm74 8134 17 respiratory respiratory NN cord-015021-pol2qm74 8134 18 ( ( -LRB- cord-015021-pol2qm74 8134 19 corona- corona- JJ cord-015021-pol2qm74 8134 20 , , , cord-015021-pol2qm74 8134 21 adeno- adeno- NN cord-015021-pol2qm74 8134 22 , , , cord-015021-pol2qm74 8134 23 RS rs NN cord-015021-pol2qm74 8134 24 - - : cord-015021-pol2qm74 8134 25 and and CC cord-015021-pol2qm74 8134 26 other other JJ cord-015021-pol2qm74 8134 27 ) ) -RRB- cord-015021-pol2qm74 8134 28 infection infection NN cord-015021-pol2qm74 8134 29 . . . cord-015021-pol2qm74 8135 1 Our -PRON- PRP$ cord-015021-pol2qm74 8135 2 previous previous JJ cord-015021-pol2qm74 8135 3 investigations investigation NNS cord-015021-pol2qm74 8135 4 showed show VBD cord-015021-pol2qm74 8135 5 that that IN cord-015021-pol2qm74 8135 6 even even RB cord-015021-pol2qm74 8135 7 in in IN cord-015021-pol2qm74 8135 8 healthy healthy JJ cord-015021-pol2qm74 8135 9 persons person NNS cord-015021-pol2qm74 8135 10 the the DT cord-015021-pol2qm74 8135 11 viral viral JJ cord-015021-pol2qm74 8135 12 infection infection NN cord-015021-pol2qm74 8135 13 has have VBZ cord-015021-pol2qm74 8135 14 influence influence NN cord-015021-pol2qm74 8135 15 on on IN cord-015021-pol2qm74 8135 16 antibacterial antibacterial JJ cord-015021-pol2qm74 8135 17 immunity immunity NN cord-015021-pol2qm74 8135 18 , , , cord-015021-pol2qm74 8135 19 in in IN cord-015021-pol2qm74 8135 20 the the DT cord-015021-pol2qm74 8135 21 cases case NNS cord-015021-pol2qm74 8135 22 of of IN cord-015021-pol2qm74 8135 23 model model JJ cord-015021-pol2qm74 8135 24 experimental experimental JJ cord-015021-pol2qm74 8135 25 reaction reaction NN cord-015021-pol2qm74 8135 26 in in IN cord-015021-pol2qm74 8135 27 volunteers volunteer NNS cord-015021-pol2qm74 8135 28 we -PRON- PRP cord-015021-pol2qm74 8135 29 found find VBD cord-015021-pol2qm74 8135 30 the the DT cord-015021-pol2qm74 8135 31 decrease decrease NN cord-015021-pol2qm74 8135 32 of of IN cord-015021-pol2qm74 8135 33 delayed delay VBN cord-015021-pol2qm74 8135 34 hypersensitivity hypersensitivity NN cord-015021-pol2qm74 8135 35 10 10 CD cord-015021-pol2qm74 8135 36 - - SYM cord-015021-pol2qm74 8135 37 14 14 CD cord-015021-pol2qm74 8135 38 days day NNS cord-015021-pol2qm74 8135 39 after after IN cord-015021-pol2qm74 8135 40 intranasal intranasal NN cord-015021-pol2qm74 8135 41 inoculation inoculation NN cord-015021-pol2qm74 8135 42 of of IN cord-015021-pol2qm74 8135 43 influenza influenza NN cord-015021-pol2qm74 8135 44 virus virus NN cord-015021-pol2qm74 8135 45 A a NN cord-015021-pol2qm74 8135 46 ( ( -LRB- cord-015021-pol2qm74 8135 47 H3N2 H3N2 NNP cord-015021-pol2qm74 8135 48 - - HYPH cord-015021-pol2qm74 8135 49 3 3 CD cord-015021-pol2qm74 8135 50 ) ) -RRB- cord-015021-pol2qm74 8135 51 to to IN cord-015021-pol2qm74 8135 52 bacterial bacterial JJ cord-015021-pol2qm74 8135 53 ( ( -LRB- cord-015021-pol2qm74 8135 54 Staphylococcal Staphylococcal NNP cord-015021-pol2qm74 8135 55 , , , cord-015021-pol2qm74 8135 56 Streptococcal Streptococcal NNP cord-015021-pol2qm74 8135 57 and and CC cord-015021-pol2qm74 8135 58 Pneumococcal Pneumococcal NNP cord-015021-pol2qm74 8135 59 ) ) -RRB- cord-015021-pol2qm74 8135 60 and and CC cord-015021-pol2qm74 8135 61 ~iycoplasma ~iycoplasma CD cord-015021-pol2qm74 8135 62 pneumoniae pneumoniae NN cord-015021-pol2qm74 8135 63 antigens antigen NNS cord-015021-pol2qm74 8135 64 in in IN cord-015021-pol2qm74 8135 65 the the DT cord-015021-pol2qm74 8135 66 leucocyte leucocyte NNP cord-015021-pol2qm74 8135 67 migration migration NN cord-015021-pol2qm74 8135 68 inhibition inhibition NN cord-015021-pol2qm74 8135 69 test test NN cord-015021-pol2qm74 8135 70 . . . cord-015021-pol2qm74 8136 1 These these DT cord-015021-pol2qm74 8136 2 results result NNS cord-015021-pol2qm74 8136 3 showed show VBD cord-015021-pol2qm74 8136 4 that that IN cord-015021-pol2qm74 8136 5 respiratory respiratory JJ cord-015021-pol2qm74 8136 6 viruses virus NNS cord-015021-pol2qm74 8136 7 may may MD cord-015021-pol2qm74 8136 8 be be VB cord-015021-pol2qm74 8136 9 the the DT cord-015021-pol2qm74 8136 10 important important JJ cord-015021-pol2qm74 8136 11 pathogenic pathogenic JJ cord-015021-pol2qm74 8136 12 factor factor NN cord-015021-pol2qm74 8136 13 in in IN cord-015021-pol2qm74 8136 14 the the DT cord-015021-pol2qm74 8136 15 development development NN cord-015021-pol2qm74 8136 16 of of IN cord-015021-pol2qm74 8136 17 bacterial bacterial JJ cord-015021-pol2qm74 8136 18 infection infection NN cord-015021-pol2qm74 8136 19 in in IN cord-015021-pol2qm74 8136 20 posttransplanted posttransplanted JJ cord-015021-pol2qm74 8136 21 period period NN cord-015021-pol2qm74 8136 22 . . . cord-015021-pol2qm74 8137 1 We -PRON- PRP cord-015021-pol2qm74 8137 2 consider consider VBP cord-015021-pol2qm74 8137 3 the the DT cord-015021-pol2qm74 8137 4 constant constant JJ cord-015021-pol2qm74 8137 5 control control NN cord-015021-pol2qm74 8137 6 of of IN cord-015021-pol2qm74 8137 7 latent latent JJ cord-015021-pol2qm74 8137 8 and and CC cord-015021-pol2qm74 8137 9 visual visual JJ cord-015021-pol2qm74 8137 10 respiratory respiratory JJ cord-015021-pol2qm74 8137 11 viral viral JJ cord-015021-pol2qm74 8137 12 infection infection NN cord-015021-pol2qm74 8137 13 in in IN cord-015021-pol2qm74 8137 14 BMT BMT NNP cord-015021-pol2qm74 8137 15 patients patient NNS cord-015021-pol2qm74 8137 16 to to TO cord-015021-pol2qm74 8137 17 be be VB cord-015021-pol2qm74 8137 18 very very RB cord-015021-pol2qm74 8137 19 important important JJ cord-015021-pol2qm74 8137 20 . . . cord-015021-pol2qm74 8138 1 FIccB FIccB NNPS cord-015021-pol2qm74 8139 1 the the DT cord-015021-pol2qm74 8139 2 ~ter£~Li ~ter£~Li NNS cord-015021-pol2qm74 8139 3 of of IN cord-015021-pol2qm74 8139 4 the the DT cord-015021-pol2qm74 8139 5 Nation~ Nation~ NNP cord-015021-pol2qm74 8140 1 l l NNP cord-015021-pol2qm74 8140 2 Institute Institute NNP cord-015021-pol2qm74 8140 3 of of IN cord-015021-pol2qm74 8140 4 TraD/~atoloqy TraD/~atoloqy NNP cord-015021-pol2qm74 8140 5 in in IN cord-015021-pol2qm74 8140 6 Budapest Budapest NNP cord-015021-pol2qm74 8141 1 1.00 1.00 CD cord-015021-pol2qm74 8141 2 consecutive consecutive JJ cord-015021-pol2qm74 8141 3 cases case NNS cord-015021-pol2qm74 8141 4 of of IN cord-015021-pol2qm74 8141 5 revision revision NN cord-015021-pol2qm74 8141 6 hip hip NN cord-015021-pol2qm74 8141 7 grafting grafting NN cord-015021-pol2qm74 8141 8 were be VBD cord-015021-pol2qm74 8141 9 carried carry VBN cord-015021-pol2qm74 8141 10 out out RP cord-015021-pol2qm74 8141 11 arthroplasties arthroplasties NNP cord-015021-pol2qm74 8141 12 wlth wlth NNP cord-015021-pol2qm74 8141 13 hemoloquous hemoloquous NNP cord-015021-pol2qm74 8141 14 bone bone NN cord-015021-pol2qm74 8141 15 between between IN cord-015021-pol2qm74 8141 16 the the DT cord-015021-pol2qm74 8141 17 years year NNS cord-015021-pol2qm74 8141 18 1990 1990 CD cord-015021-pol2qm74 8141 19 and and CC cord-015021-pol2qm74 8141 20 1993 1993 CD cord-015021-pol2qm74 8141 21 . . . cord-015021-pol2qm74 8142 1 In in IN cord-015021-pol2qm74 8142 2 the the DT cord-015021-pol2qm74 8142 3 same same JJ cord-015021-pol2qm74 8142 4 period period NN cord-015021-pol2qm74 8142 5 of of IN cord-015021-pol2qm74 8142 6 time time NN cord-015021-pol2qm74 8142 7 732 732 CD cord-015021-pol2qm74 8142 8 pri~ pri~ CD cord-015021-pol2qm74 8142 9 total total JJ cord-015021-pol2qm74 8142 10 hlp hlp NN cord-015021-pol2qm74 8142 11 replacen replacen NN cord-015021-pol2qm74 8142 12 ~ ~ NFP cord-015021-pol2qm74 8142 13 nts nts NNPS cord-015021-pol2qm74 8142 14 were be VBD cord-015021-pol2qm74 8142 15 performed perform VBN cord-015021-pol2qm74 8142 16 under under IN cord-015021-pol2qm74 8142 17 i4entieal i4entieal JJ cord-015021-pol2qm74 8142 18 technical technical JJ cord-015021-pol2qm74 8142 19 conditions condition NNS cord-015021-pol2qm74 8142 20 . . . cord-015021-pol2qm74 8143 1 The the DT cord-015021-pol2qm74 8143 2 average average JJ cord-015021-pol2qm74 8143 3 septic septic JJ cord-015021-pol2qm74 8143 4 rate rate NN cord-015021-pol2qm74 8143 5 for for IN cord-015021-pol2qm74 8143 6 the the DT cord-015021-pol2qm74 8143 7 ' ' `` cord-015021-pol2qm74 8143 8 total total JJ cord-015021-pol2qm74 8143 9 hip hip NN cord-015021-pol2qm74 8143 10 althroplasties althroplastie NNS cord-015021-pol2qm74 8143 11 was be VBD cord-015021-pol2qm74 8143 12 less less JJR cord-015021-pol2qm74 8143 13 than than IN cord-015021-pol2qm74 8143 14 1 1 CD cord-015021-pol2qm74 8143 15 % % NN cord-015021-pol2qm74 8143 16 . . . cord-015021-pol2qm74 8144 1 In in IN cord-015021-pol2qm74 8144 2 the the DT cord-015021-pol2qm74 8144 3 selected select VBN cord-015021-pol2qm74 8144 4 i00 i00 NN cord-015021-pol2qm74 8144 5 cases case NNS cord-015021-pol2qm74 8144 6 the the DT cord-015021-pol2qm74 8144 7 septic septic JJ cord-015021-pol2qm74 8144 8 rate rate NN cord-015021-pol2qm74 8144 9 was be VBD cord-015021-pol2qm74 8144 10 4 4 CD cord-015021-pol2qm74 8144 11 % % NN cord-015021-pol2qm74 8144 12 indicating indicate VBG cord-015021-pol2qm74 8144 13 the the DT cord-015021-pol2qm74 8144 14 role role NN cord-015021-pol2qm74 8144 15 of of IN cord-015021-pol2qm74 8144 16 bone bone NN cord-015021-pol2qm74 8144 17 grafting grafting NN cord-015021-pol2qm74 8144 18 ° ° NN cord-015021-pol2qm74 8144 19 Homografts Homografts NNP cord-015021-pol2qm74 8144 20 were be VBD cord-015021-pol2qm74 8144 21 prepared prepare VBN cord-015021-pol2qm74 8144 22 by by IN cord-015021-pol2qm74 8144 23 deep deep JJ cord-015021-pol2qm74 8144 24 freezing~ freezing~ NNP cord-015021-pol2qm74 8144 25 It -PRON- PRP cord-015021-pol2qm74 8144 26 .is .is XX cord-015021-pol2qm74 8144 27 recognized recognize VBD cord-015021-pol2qm74 8144 28 that that IN cord-015021-pol2qm74 8144 29 the the DT cord-015021-pol2qm74 8144 30 cells cell NNS cord-015021-pol2qm74 8144 31 of of IN cord-015021-pol2qm74 8144 32 the the DT cord-015021-pol2qm74 8144 33 hL hL NNP cord-015021-pol2qm74 8144 34 ~ ~ NFP cord-015021-pol2qm74 8144 35 grafts graft NNS cord-015021-pol2qm74 8144 36 become become VBP cord-015021-pol2qm74 8144 37 destroyed destroy VBN cord-015021-pol2qm74 8144 38 by by IN cord-015021-pol2qm74 8144 39 the the DT cord-015021-pol2qm74 8144 40 ium ium NN cord-015021-pol2qm74 8144 41 ~ ~ NFP cord-015021-pol2qm74 8144 42 unological unological JJ cord-015021-pol2qm74 8144 43 , , , cord-015021-pol2qm74 8144 44 response response NN cord-015021-pol2qm74 8144 45 of of IN cord-015021-pol2qm74 8144 46 the the DT cord-015021-pol2qm74 8144 47 host~ host~ NNP cord-015021-pol2qm74 8144 48 and and CC cord-015021-pol2qm74 8144 49 the the DT cord-015021-pol2qm74 8144 50 patients patient NNS cord-015021-pol2qm74 8144 51 develop develop VBP cord-015021-pol2qm74 8144 52 ~ti ~ti NNP cord-015021-pol2qm74 8144 53 - - HYPH cord-015021-pol2qm74 8144 54 HL~ HL~ NNP cord-015021-pol2qm74 8144 55 , , , cord-015021-pol2qm74 8144 56 ar ar NNP cord-015021-pol2qm74 8144 57 ~ ~ NFP cord-015021-pol2qm74 8144 58 tib'o tib'o NNS cord-015021-pol2qm74 8144 59 ~ ~ NFP cord-015021-pol2qm74 8144 60 ies ie NNS cord-015021-pol2qm74 8144 61 . . . cord-015021-pol2qm74 8145 1 The the DT cord-015021-pol2qm74 8145 2 dead dead JJ cord-015021-pol2qm74 8146 1 ~trix ~trix NFP cord-015021-pol2qm74 8146 2 , , , cord-015021-pol2qm74 8146 3 however however RB cord-015021-pol2qm74 8146 4 , , , cord-015021-pol2qm74 8146 5 has have VBZ cord-015021-pol2qm74 8146 6 a a DT cord-015021-pol2qm74 8146 7 bone bone NN cord-015021-pol2qm74 8146 8 - - HYPH cord-015021-pol2qm74 8146 9 inducing induce VBG cord-015021-pol2qm74 8146 10 capacity capacity NN cord-015021-pol2qm74 8146 11 that that WDT cord-015021-pol2qm74 8146 12 stimulates stimulate VBZ cord-015021-pol2qm74 8146 13 host host NN cord-015021-pol2qm74 8146 14 osteoblasts osteoblast NNS cord-015021-pol2qm74 8146 15 to to TO cord-015021-pol2qm74 8146 16 recolonize recolonize VB cord-015021-pol2qm74 8146 17 the the DT cord-015021-pol2qm74 8146 18 * * NFP cord-015021-pol2qm74 8146 19 I~/trix I~/trix NNP cord-015021-pol2qm74 8146 20 Which which WDT cord-015021-pol2qm74 8146 21 serves serve VBZ cord-015021-pol2qm74 8146 22 as as IN cord-015021-pol2qm74 8146 23 scaffolding scaffolding NN cord-015021-pol2qm74 8146 24 . . . cord-015021-pol2qm74 8147 1 The the DT cord-015021-pol2qm74 8147 2 sequence sequence NN cord-015021-pol2qm74 8147 3 of of IN cord-015021-pol2qm74 8147 4 events event NNS cord-015021-pol2qm74 8147 5 favours favour VBZ cord-015021-pol2qm74 8147 6 the the DT cord-015021-pol2qm74 8147 7 infections infection NNS cord-015021-pol2qm74 8147 8 . . . cord-015021-pol2qm74 8148 1 For for IN cord-015021-pol2qm74 8148 2 this this DT cord-015021-pol2qm74 8148 3 reason reason NN cord-015021-pol2qm74 8148 4 , , , cord-015021-pol2qm74 8148 5 beside beside IN cord-015021-pol2qm74 8148 6 preventive preventive JJ cord-015021-pol2qm74 8148 7 perioperative perioperative JJ cord-015021-pol2qm74 8148 8 systemic systemic JJ cord-015021-pol2qm74 8148 9 ant ant JJ cord-015021-pol2qm74 8148 10 / / SYM cord-015021-pol2qm74 8148 11 biotic biotic JJ cord-015021-pol2qm74 8148 12 treatment treatment NN cord-015021-pol2qm74 8148 13 , , , cord-015021-pol2qm74 8148 14 local local JJ cord-015021-pol2qm74 8148 15 ~ntibioties ~ntibioties NNP cord-015021-pol2qm74 8148 16 were be VBD cord-015021-pol2qm74 8148 17 also also RB cord-015021-pol2qm74 8148 18 applied apply VBN cord-015021-pol2qm74 8148 19 in in IN cord-015021-pol2qm74 8148 20 the the DT cord-015021-pol2qm74 8148 21 form form NN cord-015021-pol2qm74 8148 22 of of IN cord-015021-pol2qm74 8148 23 antibiotic-//npregnated antibiotic-//npregnate VBN cord-015021-pol2qm74 8148 24 cement cement NN cord-015021-pol2qm74 8148 25 . . . cord-015021-pol2qm74 8149 1 The the DT cord-015021-pol2qm74 8149 2 role role NN cord-015021-pol2qm74 8149 3 of of IN cord-015021-pol2qm74 8149 4 age age NN cord-015021-pol2qm74 8149 5 and and CC cord-015021-pol2qm74 8149 6 the the DT cord-015021-pol2qm74 8149 7 .immune .immune NNP cord-015021-pol2qm74 8149 8 status status NN cord-015021-pol2qm74 8149 9 of of IN cord-015021-pol2qm74 8149 10 the the DT cord-015021-pol2qm74 8149 11 patients patient NNS cord-015021-pol2qm74 8149 12 .is .is NNP cord-015021-pol2qm74 8149 13 discussed discuss VBD cord-015021-pol2qm74 8149 14 .. .. . cord-015021-pol2qm74 8150 1 The the DT cord-015021-pol2qm74 8150 2 purpose purpose NN cord-015021-pol2qm74 8150 3 of of IN cord-015021-pol2qm74 8150 4 this this DT cord-015021-pol2qm74 8150 5 study study NN cord-015021-pol2qm74 8150 6 is be VBZ cord-015021-pol2qm74 8150 7 to to TO cord-015021-pol2qm74 8150 8 evaluate evaluate VB cord-015021-pol2qm74 8150 9 the the DT cord-015021-pol2qm74 8150 10 rate rate NN cord-015021-pol2qm74 8150 11 of of IN cord-015021-pol2qm74 8150 12 toxemia toxemia NN cord-015021-pol2qm74 8150 13 in in IN cord-015021-pol2qm74 8150 14 patients patient NNS cord-015021-pol2qm74 8150 15 with with IN cord-015021-pol2qm74 8150 16 acute acute JJ cord-015021-pol2qm74 8150 17 panereatitis panereatitis NN cord-015021-pol2qm74 8150 18 and and CC cord-015021-pol2qm74 8150 19 to to TO cord-015021-pol2qm74 8150 20 find find VB cord-015021-pol2qm74 8150 21 this this DT cord-015021-pol2qm74 8150 22 coudition coudition NN cord-015021-pol2qm74 8150 23 to to IN cord-015021-pol2qm74 8150 24 the the DT cord-015021-pol2qm74 8150 25 activation activation NN cord-015021-pol2qm74 8150 26 of of IN cord-015021-pol2qm74 8150 27 cascade cascade NN cord-015021-pol2qm74 8150 28 systems system NNS cord-015021-pol2qm74 8150 29 that that WDT cord-015021-pol2qm74 8150 30 are be VBP cord-015021-pol2qm74 8150 31 encountered encounter VBN cord-015021-pol2qm74 8150 32 in in IN cord-015021-pol2qm74 8150 33 the the DT cord-015021-pol2qm74 8150 34 subsequent subsequent JJ cord-015021-pol2qm74 8150 35 complications complication NNS cord-015021-pol2qm74 8150 36 of of IN cord-015021-pol2qm74 8150 37 the the DT cord-015021-pol2qm74 8150 38 disease disease NN cord-015021-pol2qm74 8150 39 . . . cord-015021-pol2qm74 8151 1 We -PRON- PRP cord-015021-pol2qm74 8151 2 studied study VBD cord-015021-pol2qm74 8151 3 a a DT cord-015021-pol2qm74 8151 4 series series NN cord-015021-pol2qm74 8151 5 of of IN cord-015021-pol2qm74 8151 6 45 45 CD cord-015021-pol2qm74 8151 7 patients patient NNS cord-015021-pol2qm74 8151 8 with with IN cord-015021-pol2qm74 8151 9 acute acute JJ cord-015021-pol2qm74 8151 10 pancreatitis pancreatitis NN cord-015021-pol2qm74 8151 11 , , , cord-015021-pol2qm74 8151 12 the the DT cord-015021-pol2qm74 8151 13 severeness severeness NN cord-015021-pol2qm74 8151 14 of of IN cord-015021-pol2qm74 8151 15 which which WDT cord-015021-pol2qm74 8151 16 was be VBD cord-015021-pol2qm74 8151 17 evaluated evaluate VBN cord-015021-pol2qm74 8151 18 by by IN cord-015021-pol2qm74 8151 19 the the DT cord-015021-pol2qm74 8151 20 Ranson Ranson NNP cord-015021-pol2qm74 8151 21 's 's POS cord-015021-pol2qm74 8151 22 criteria criterion NNS cord-015021-pol2qm74 8151 23 and and CC cord-015021-pol2qm74 8151 24 the the DT cord-015021-pol2qm74 8151 25 Apach Apach NNP cord-015021-pol2qm74 8151 26 - - HYPH cord-015021-pol2qm74 8151 27 II II NNP cord-015021-pol2qm74 8151 28 scoring scoring NN cord-015021-pol2qm74 8151 29 system system NN cord-015021-pol2qm74 8151 30 . . . cord-015021-pol2qm74 8152 1 All all DT cord-015021-pol2qm74 8152 2 of of IN cord-015021-pol2qm74 8152 3 them -PRON- PRP cord-015021-pol2qm74 8152 4 were be VBD cord-015021-pol2qm74 8152 5 considered consider VBN cord-015021-pol2qm74 8152 6 to to TO cord-015021-pol2qm74 8152 7 have have VB cord-015021-pol2qm74 8152 8 severe severe JJ cord-015021-pol2qm74 8152 9 acute acute JJ cord-015021-pol2qm74 8152 10 puncreatitis puncreatitis NN cord-015021-pol2qm74 8152 11 . . . cord-015021-pol2qm74 8153 1 The the DT cord-015021-pol2qm74 8153 2 determination determination NN cord-015021-pol2qm74 8153 3 of of IN cord-015021-pol2qm74 8153 4 toxemia toxemia NN cord-015021-pol2qm74 8153 5 was be VBD cord-015021-pol2qm74 8153 6 made make VBN cord-015021-pol2qm74 8153 7 using use VBG cord-015021-pol2qm74 8153 8 the the DT cord-015021-pol2qm74 8153 9 Limulus Limulus NNP cord-015021-pol2qm74 8153 10 test test NN cord-015021-pol2qm74 8153 11 ( ( -LRB- cord-015021-pol2qm74 8153 12 LAL LAL NNP cord-015021-pol2qm74 8153 13 test test NN cord-015021-pol2qm74 8153 14 ) ) -RRB- cord-015021-pol2qm74 8153 15 . . . cord-015021-pol2qm74 8154 1 We -PRON- PRP cord-015021-pol2qm74 8154 2 also also RB cord-015021-pol2qm74 8154 3 determined determine VBD cord-015021-pol2qm74 8154 4 the the DT cord-015021-pol2qm74 8154 5 levels level NNS cord-015021-pol2qm74 8154 6 of of IN cord-015021-pol2qm74 8154 7 the the DT cord-015021-pol2qm74 8154 8 third third JJ cord-015021-pol2qm74 8154 9 ( ( -LRB- cord-015021-pol2qm74 8154 10 C3 C3 NNP cord-015021-pol2qm74 8154 11 ) ) -RRB- cord-015021-pol2qm74 8154 12 and and CC cord-015021-pol2qm74 8154 13 fourth fourth JJ cord-015021-pol2qm74 8154 14 ( ( -LRB- cord-015021-pol2qm74 8154 15 C4 C4 NNP cord-015021-pol2qm74 8154 16 ) ) -RRB- cord-015021-pol2qm74 8154 17 Complement complement JJ cord-015021-pol2qm74 8154 18 components component NNS cord-015021-pol2qm74 8154 19 as as IN cord-015021-pol2qm74 8154 20 weU weU NNP cord-015021-pol2qm74 8154 21 as as IN cord-015021-pol2qm74 8154 22 the the DT cord-015021-pol2qm74 8154 23 coagulation coagulation NN cord-015021-pol2qm74 8154 24 factors factor NNS cord-015021-pol2qm74 8154 25 , , , cord-015021-pol2qm74 8154 26 Iibrinolysis Iibrinolysis NNP cord-015021-pol2qm74 8154 27 faeters faeter NNS cord-015021-pol2qm74 8154 28 and and CC cord-015021-pol2qm74 8154 29 Kimns Kimns NNP cord-015021-pol2qm74 8154 30 by by IN cord-015021-pol2qm74 8154 31 serial serial JJ cord-015021-pol2qm74 8154 32 measurements measurement NNS cord-015021-pol2qm74 8154 33 . . . cord-015021-pol2qm74 8155 1 The the DT cord-015021-pol2qm74 8155 2 severity severity NN cord-015021-pol2qm74 8155 3 of of IN cord-015021-pol2qm74 8155 4 the the DT cord-015021-pol2qm74 8155 5 disease disease NN cord-015021-pol2qm74 8155 6 was be VBD cord-015021-pol2qm74 8155 7 serially serially RB cord-015021-pol2qm74 8155 8 determined determine VBN cord-015021-pol2qm74 8155 9 by by IN cord-015021-pol2qm74 8155 10 the the DT cord-015021-pol2qm74 8155 11 Apach Apach NNP cord-015021-pol2qm74 8155 12 - - HYPH cord-015021-pol2qm74 8155 13 II II NNP cord-015021-pol2qm74 8155 14 scoring scoring NN cord-015021-pol2qm74 8155 15 system system NN cord-015021-pol2qm74 8155 16 . . . cord-015021-pol2qm74 8156 1 It -PRON- PRP cord-015021-pol2qm74 8156 2 was be VBD cord-015021-pol2qm74 8156 3 found find VBN cord-015021-pol2qm74 8156 4 that that IN cord-015021-pol2qm74 8156 5 Complement Complement NNP cord-015021-pol2qm74 8156 6 activation activation NN cord-015021-pol2qm74 8156 7 ( ( -LRB- cord-015021-pol2qm74 8156 8 which which WDT cord-015021-pol2qm74 8156 9 was be VBD cord-015021-pol2qm74 8156 10 also also RB cord-015021-pol2qm74 8156 11 assessed assess VBN cord-015021-pol2qm74 8156 12 using use VBG cord-015021-pol2qm74 8156 13 a a DT cord-015021-pol2qm74 8156 14 graphically graphically RB cord-015021-pol2qm74 8156 15 illustrated illustrate VBN cord-015021-pol2qm74 8156 16 method method NN cord-015021-pol2qm74 8156 17 by by IN cord-015021-pol2qm74 8156 18 a a DT cord-015021-pol2qm74 8156 19 aggregometer aggregometer NN cord-015021-pol2qm74 8156 20 ) ) -RRB- cord-015021-pol2qm74 8156 21 was be VBD cord-015021-pol2qm74 8156 22 followed follow VBN cord-015021-pol2qm74 8156 23 by by IN cord-015021-pol2qm74 8156 24 an an DT cord-015021-pol2qm74 8156 25 increase increase NN cord-015021-pol2qm74 8156 26 of of IN cord-015021-pol2qm74 8156 27 morbitity morbitity NN cord-015021-pol2qm74 8156 28 and and CC cord-015021-pol2qm74 8156 29 mortality mortality NN cord-015021-pol2qm74 8156 30 .We .We . cord-015021-pol2qm74 8157 1 also also RB cord-015021-pol2qm74 8157 2 detected detect VBD cord-015021-pol2qm74 8157 3 that that IN cord-015021-pol2qm74 8157 4 toxemia toxemia NN cord-015021-pol2qm74 8157 5 ( ( -LRB- cord-015021-pol2qm74 8157 6 positive positive JJ cord-015021-pol2qm74 8157 7 LAL LAL NNP cord-015021-pol2qm74 8157 8 - - HYPH cord-015021-pol2qm74 8157 9 test test NN cord-015021-pol2qm74 8157 10 ) ) -RRB- cord-015021-pol2qm74 8157 11 was be VBD cord-015021-pol2qm74 8157 12 closely closely RB cord-015021-pol2qm74 8157 13 correlated correlate VBN cord-015021-pol2qm74 8157 14 with with IN cord-015021-pol2qm74 8157 15 complement complement JJ cord-015021-pol2qm74 8157 16 activation activation NN cord-015021-pol2qm74 8157 17 and and CC cord-015021-pol2qm74 8157 18 more more JJR cord-015021-pol2qm74 8157 19 of of IN cord-015021-pol2qm74 8157 20 the the DT cord-015021-pol2qm74 8157 21 Ranson Ranson NNP cord-015021-pol2qm74 8157 22 's 's POS cord-015021-pol2qm74 8157 23 criteria criterion NNS cord-015021-pol2qm74 8157 24 . . . cord-015021-pol2qm74 8158 1 A a DT cord-015021-pol2qm74 8158 2 clear clear JJ cord-015021-pol2qm74 8158 3 relation relation NN cord-015021-pol2qm74 8158 4 existed exist VBD cord-015021-pol2qm74 8158 5 between between IN cord-015021-pol2qm74 8158 6 the the DT cord-015021-pol2qm74 8158 7 number number NN cord-015021-pol2qm74 8158 8 of of IN cord-015021-pol2qm74 8158 9 Ranson Ranson NNP cord-015021-pol2qm74 8158 10 's 's POS cord-015021-pol2qm74 8158 11 signs sign NNS cord-015021-pol2qm74 8158 12 and and CC cord-015021-pol2qm74 8158 13 the the DT cord-015021-pol2qm74 8158 14 enmplieations enmplieation NNS cord-015021-pol2qm74 8158 15 ' ' POS cord-015021-pol2qm74 8158 16 rate rate NN cord-015021-pol2qm74 8158 17 ( ( -LRB- cord-015021-pol2qm74 8158 18 1"= 1"= CD cord-015021-pol2qm74 8158 19 -0.766 -0.766 NNP cord-015021-pol2qm74 8158 20 , , , cord-015021-pol2qm74 8158 21 p p NN cord-015021-pol2qm74 8158 22 < < XX cord-015021-pol2qm74 8158 23 0.001 0.001 CD cord-015021-pol2qm74 8158 24 ) ) -RRB- cord-015021-pol2qm74 8158 25 . . . cord-015021-pol2qm74 8159 1 The the DT cord-015021-pol2qm74 8159 2 documentation documentation NN cord-015021-pol2qm74 8159 3 of of IN cord-015021-pol2qm74 8159 4 toxemia toxemia NN cord-015021-pol2qm74 8159 5 and and CC cord-015021-pol2qm74 8159 6 the the DT cord-015021-pol2qm74 8159 7 complement complement JJ cord-015021-pol2qm74 8159 8 activation activation NN cord-015021-pol2qm74 8159 9 can can MD cord-015021-pol2qm74 8159 10 not not RB cord-015021-pol2qm74 8159 11 predict predict VB cord-015021-pol2qm74 8159 12 the the DT cord-015021-pol2qm74 8159 13 kind kind NN cord-015021-pol2qm74 8159 14 and and CC cord-015021-pol2qm74 8159 15 the the DT cord-015021-pol2qm74 8159 16 severity severity NN cord-015021-pol2qm74 8159 17 of of IN cord-015021-pol2qm74 8159 18 complications complication NNS cord-015021-pol2qm74 8159 19 . . . cord-015021-pol2qm74 8160 1 The the DT cord-015021-pol2qm74 8160 2 study study NN cord-015021-pol2qm74 8160 3 of of IN cord-015021-pol2qm74 8160 4 coagulation coagulation NN cord-015021-pol2qm74 8160 5 , , , cord-015021-pol2qm74 8160 6 fibrinolysis fibrinolysis NN cord-015021-pol2qm74 8160 7 and and CC cord-015021-pol2qm74 8160 8 kinms kinms NNP cord-015021-pol2qm74 8160 9 systems system NNS cord-015021-pol2qm74 8160 10 did do VBD cord-015021-pol2qm74 8160 11 n't not RB cord-015021-pol2qm74 8160 12 reveal reveal VB cord-015021-pol2qm74 8160 13 any any DT cord-015021-pol2qm74 8160 14 results result NNS cord-015021-pol2qm74 8160 15 with with IN cord-015021-pol2qm74 8160 16 statistical statistical JJ cord-015021-pol2qm74 8160 17 significance significance NN cord-015021-pol2qm74 8160 18 . . . cord-015021-pol2qm74 8161 1 Necrotizing necrotize VBG cord-015021-pol2qm74 8161 2 pancreatitis pancreatitis NN cord-015021-pol2qm74 8161 3 still still RB cord-015021-pol2qm74 8161 4 represents represent VBZ cord-015021-pol2qm74 8161 5 a a DT cord-015021-pol2qm74 8161 6 life life NN cord-015021-pol2qm74 8161 7 - - HYPH cord-015021-pol2qm74 8161 8 threatenthg threatenthg NN cord-015021-pol2qm74 8161 9 disease disease NN cord-015021-pol2qm74 8161 10 . . . cord-015021-pol2qm74 8162 1 Infectious infectious JJ cord-015021-pol2qm74 8162 2 complications complication NNS cord-015021-pol2qm74 8162 3 dominate dominate VBP cord-015021-pol2qm74 8162 4 among among IN cord-015021-pol2qm74 8162 5 the the DT cord-015021-pol2qm74 8162 6 causes cause NNS cord-015021-pol2qm74 8162 7 of of IN cord-015021-pol2qm74 8162 8 death death NN cord-015021-pol2qm74 8162 9 . . . cord-015021-pol2qm74 8163 1 Differences difference NNS cord-015021-pol2qm74 8163 2 in in IN cord-015021-pol2qm74 8163 3 the the DT cord-015021-pol2qm74 8163 4 individual individual JJ cord-015021-pol2qm74 8163 5 immune immune JJ cord-015021-pol2qm74 8163 6 response response NN cord-015021-pol2qm74 8163 7 could could MD cord-015021-pol2qm74 8163 8 possibly possibly RB cord-015021-pol2qm74 8163 9 explain explain VB cord-015021-pol2qm74 8163 10 different different JJ cord-015021-pol2qm74 8163 11 clinical clinical JJ cord-015021-pol2qm74 8163 12 courses course NNS cord-015021-pol2qm74 8163 13 even even RB cord-015021-pol2qm74 8163 14 in in IN cord-015021-pol2qm74 8163 15 patients patient NNS cord-015021-pol2qm74 8163 16 with with IN cord-015021-pol2qm74 8163 17 comparable comparable JJ cord-015021-pol2qm74 8163 18 pancreatic pancreatic JJ cord-015021-pol2qm74 8163 19 morphology morphology NN cord-015021-pol2qm74 8163 20 . . . cord-015021-pol2qm74 8164 1 To to TO cord-015021-pol2qm74 8164 2 explore explore VB cord-015021-pol2qm74 8164 3 the the DT cord-015021-pol2qm74 8164 4 inflammatory inflammatory JJ cord-015021-pol2qm74 8164 5 response response NN cord-015021-pol2qm74 8164 6 in in IN cord-015021-pol2qm74 8164 7 acute acute JJ cord-015021-pol2qm74 8164 8 pancreatitis pancreatitis NN cord-015021-pol2qm74 8164 9 , , , cord-015021-pol2qm74 8164 10 the the DT cord-015021-pol2qm74 8164 11 following follow VBG cord-015021-pol2qm74 8164 12 investigation investigation NN cord-015021-pol2qm74 8164 13 was be VBD cord-015021-pol2qm74 8164 14 performed perform VBN cord-015021-pol2qm74 8164 15 . . . cord-015021-pol2qm74 8165 1 Methods method NNS cord-015021-pol2qm74 8165 2 : : : cord-015021-pol2qm74 8166 1 Peripheral peripheral JJ cord-015021-pol2qm74 8166 2 - - HYPH cord-015021-pol2qm74 8166 3 venous venous JJ cord-015021-pol2qm74 8166 4 blood blood NN cord-015021-pol2qm74 8166 5 was be VBD cord-015021-pol2qm74 8166 6 withdrawn withdraw VBN cord-015021-pol2qm74 8166 7 on on IN cord-015021-pol2qm74 8166 8 admission admission NN cord-015021-pol2qm74 8166 9 and and CC cord-015021-pol2qm74 8166 10 furthermore furthermore RB cord-015021-pol2qm74 8166 11 twice twice RB cord-015021-pol2qm74 8166 12 weekly weekly RB cord-015021-pol2qm74 8166 13 in in IN cord-015021-pol2qm74 8166 14 as as IN cord-015021-pol2qm74 8166 15 yet yet RB cord-015021-pol2qm74 8166 16 36 36 CD cord-015021-pol2qm74 8166 17 patients patient NNS cord-015021-pol2qm74 8166 18 with with IN cord-015021-pol2qm74 8166 19 acute acute JJ cord-015021-pol2qm74 8166 20 pancreatitis pancreatitis NN cord-015021-pol2qm74 8166 21 and and CC cord-015021-pol2qm74 8166 22 tested test VBN cord-015021-pol2qm74 8166 23 for for IN cord-015021-pol2qm74 8166 24 the the DT cord-015021-pol2qm74 8166 25 parameters parameter NNS cord-015021-pol2qm74 8166 26 mentioned mention VBN cord-015021-pol2qm74 8166 27 below below RB cord-015021-pol2qm74 8166 28 . . . cord-015021-pol2qm74 8167 1 In in IN cord-015021-pol2qm74 8167 2 parallel parallel JJ cord-015021-pol2qm74 8167 3 , , , cord-015021-pol2qm74 8167 4 polymorphounciear polymorphounciear NNP cord-015021-pol2qm74 8167 5 granaIocytes granaIocytes NNPS cord-015021-pol2qm74 8167 6 were be VBD cord-015021-pol2qm74 8167 7 isolated isolate VBN cord-015021-pol2qm74 8167 8 using use VBG cord-015021-pol2qm74 8167 9 density density NN cord-015021-pol2qm74 8167 10 gradient gradient NN cord-015021-pol2qm74 8167 11 centrifugation centrifugation NN cord-015021-pol2qm74 8167 12 and and CC cord-015021-pol2qm74 8167 13 assessed assess VBN cord-015021-pol2qm74 8167 14 for for IN cord-015021-pol2qm74 8167 15 superoxide superoxide NN cord-015021-pol2qm74 8167 16 anion anion NN cord-015021-pol2qm74 8167 17 and and CC cord-015021-pol2qm74 8167 18 hydroxyl hydroxyl NN cord-015021-pol2qm74 8167 19 radical radical JJ cord-015021-pol2qm74 8167 20 producing produce VBG cord-015021-pol2qm74 8167 21 capacity capacity NN cord-015021-pol2qm74 8167 22 using use VBG cord-015021-pol2qm74 8167 23 electron electron NN cord-015021-pol2qm74 8167 24 spin spin NN cord-015021-pol2qm74 8167 25 resonance resonance NN cord-015021-pol2qm74 8167 26 techniques technique NNS cord-015021-pol2qm74 8167 27 . . . cord-015021-pol2qm74 8168 1 Results result NNS cord-015021-pol2qm74 8168 2 : : : cord-015021-pol2qm74 8168 3 Total total JJ cord-015021-pol2qm74 8168 4 leukocyte leukocyte NN cord-015021-pol2qm74 8168 5 cotmt cotmt NN cord-015021-pol2qm74 8168 6 and and CC cord-015021-pol2qm74 8168 7 total total JJ cord-015021-pol2qm74 8168 8 lymphocyte lymphocyte NN cord-015021-pol2qm74 8168 9 count count NN cord-015021-pol2qm74 8169 1 did do VBD cord-015021-pol2qm74 8169 2 neither neither CC cord-015021-pol2qm74 8169 3 reflect reflect VB cord-015021-pol2qm74 8169 4 the the DT cord-015021-pol2qm74 8169 5 clinical clinical JJ cord-015021-pol2qm74 8169 6 course course NN cord-015021-pol2qm74 8169 7 nor nor CC cord-015021-pol2qm74 8169 8 predict predict VB cord-015021-pol2qm74 8169 9 complications complication NNS cord-015021-pol2qm74 8169 10 . . . cord-015021-pol2qm74 8170 1 This this DT cord-015021-pol2qm74 8170 2 comes come VBZ cord-015021-pol2qm74 8170 3 tree tree NN cord-015021-pol2qm74 8170 4 also also RB cord-015021-pol2qm74 8170 5 for for IN cord-015021-pol2qm74 8170 6 serum serum NN cord-015021-pol2qm74 8170 7 IgG IgG NNP cord-015021-pol2qm74 8170 8 , , , cord-015021-pol2qm74 8170 9 IgM IgM NNP cord-015021-pol2qm74 8170 10 , , , cord-015021-pol2qm74 8170 11 IgA IgA NNP cord-015021-pol2qm74 8170 12 , , , cord-015021-pol2qm74 8170 13 C3 C3 NNP cord-015021-pol2qm74 8170 14 , , , cord-015021-pol2qm74 8170 15 C4 C4 NNP cord-015021-pol2qm74 8170 16 , , , cord-015021-pol2qm74 8170 17 CRP CRP NNP cord-015021-pol2qm74 8170 18 , , , cord-015021-pol2qm74 8170 19 alpha alpha NN cord-015021-pol2qm74 8170 20 - - HYPH cord-015021-pol2qm74 8170 21 l l NN cord-015021-pol2qm74 8170 22 - - HYPH cord-015021-pol2qm74 8170 23 antitrypsin antitrypsin NN cord-015021-pol2qm74 8170 24 and and CC cord-015021-pol2qm74 8170 25 neopterth neopterth JJ cord-015021-pol2qm74 8170 26 as as RB cord-015021-pol2qm74 8170 27 well well RB cord-015021-pol2qm74 8170 28 as as IN cord-015021-pol2qm74 8170 29 for for IN cord-015021-pol2qm74 8170 30 plasma plasma NN cord-015021-pol2qm74 8170 31 IL IL NNP cord-015021-pol2qm74 8170 32 - - HYPH cord-015021-pol2qm74 8170 33 la la NNP cord-015021-pol2qm74 8170 34 , , , cord-015021-pol2qm74 8170 35 IL IL NNP cord-015021-pol2qm74 8170 36 - - HYPH cord-015021-pol2qm74 8170 37 IB IB NNP cord-015021-pol2qm74 8170 38 , , , cord-015021-pol2qm74 8170 39 IL-1RA IL-1RA NNP cord-015021-pol2qm74 8170 40 , , , cord-015021-pol2qm74 8170 41 IL-2 IL-2 NNP cord-015021-pol2qm74 8170 42 , , , cord-015021-pol2qm74 8170 43 IL-2R IL-2R NNP cord-015021-pol2qm74 8170 44 , , , cord-015021-pol2qm74 8170 45 IL-6R IL-6R NNP cord-015021-pol2qm74 8170 46 , , , cord-015021-pol2qm74 8170 47 TNF TNF NNP cord-015021-pol2qm74 8170 48 - - HYPH cord-015021-pol2qm74 8170 49 ct ct NNP cord-015021-pol2qm74 8170 50 , , , cord-015021-pol2qm74 8170 51 TNF-~R TNF-~R NNP cord-015021-pol2qm74 8170 52 ( ( -LRB- cord-015021-pol2qm74 8170 53 p75 p75 NNP cord-015021-pol2qm74 8170 54 ) ) -RRB- cord-015021-pol2qm74 8170 55 and and CC cord-015021-pol2qm74 8170 56 ICAM-1 ICAM-1 NNP cord-015021-pol2qm74 8170 57 . . . cord-015021-pol2qm74 8171 1 In in IN cord-015021-pol2qm74 8171 2 contrast contrast NN cord-015021-pol2qm74 8171 3 , , , cord-015021-pol2qm74 8171 4 PMN pmn NN cord-015021-pol2qm74 8171 5 - - HYPH cord-015021-pol2qm74 8171 6 elastase elastase NN cord-015021-pol2qm74 8171 7 , , , cord-015021-pol2qm74 8171 8 IL-6 IL-6 NNP cord-015021-pol2qm74 8171 9 and and CC cord-015021-pol2qm74 8171 10 IL-8 IL-8 NNP cord-015021-pol2qm74 8171 11 closely closely RB cord-015021-pol2qm74 8171 12 correlated correlate VBD cord-015021-pol2qm74 8171 13 to to IN cord-015021-pol2qm74 8171 14 the the DT cord-015021-pol2qm74 8171 15 clinical clinical JJ cord-015021-pol2qm74 8171 16 course course NN cord-015021-pol2qm74 8171 17 . . . cord-015021-pol2qm74 8172 1 Isolated isolated JJ cord-015021-pol2qm74 8172 2 PMN PMN NNP cord-015021-pol2qm74 8172 3 's 's POS cord-015021-pol2qm74 8172 4 in in IN cord-015021-pol2qm74 8172 5 vitro vitro FW cord-015021-pol2qm74 8172 6 capacity capacity NN cord-015021-pol2qm74 8172 7 to to TO cord-015021-pol2qm74 8172 8 produce produce VB cord-015021-pol2qm74 8172 9 oxygen oxygen NN cord-015021-pol2qm74 8172 10 radicals radical NNS cord-015021-pol2qm74 8172 11 depended depend VBN cord-015021-pol2qm74 8172 12 on on IN cord-015021-pol2qm74 8172 13 the the DT cord-015021-pol2qm74 8172 14 respective respective JJ cord-015021-pol2qm74 8172 15 radical radical JJ cord-015021-pol2qm74 8172 16 species specie NNS cord-015021-pol2qm74 8172 17 and and CC cord-015021-pol2qm74 8172 18 was be VBD cord-015021-pol2qm74 8172 19 slightly slightly RB cord-015021-pol2qm74 8172 20 elevated elevated JJ cord-015021-pol2qm74 8172 21 ( ( -LRB- cord-015021-pol2qm74 8172 22 superoxide superoxide NN cord-015021-pol2qm74 8172 23 anions anion NNS cord-015021-pol2qm74 8172 24 ) ) -RRB- cord-015021-pol2qm74 8172 25 or or CC cord-015021-pol2qm74 8172 26 decreased decrease VBN cord-015021-pol2qm74 8172 27 ( ( -LRB- cord-015021-pol2qm74 8172 28 hydroxyl hydroxyl NN cord-015021-pol2qm74 8172 29 radicals radical NNS cord-015021-pol2qm74 8172 30 ) ) -RRB- cord-015021-pol2qm74 8172 31 , , , cord-015021-pol2qm74 8172 32 respectively respectively RB cord-015021-pol2qm74 8172 33 . . . cord-015021-pol2qm74 8173 1 Patients patient NNS cord-015021-pol2qm74 8173 2 with with IN cord-015021-pol2qm74 8173 3 a a DT cord-015021-pol2qm74 8173 4 CD4+/CD8 cd4+/cd8 NN cord-015021-pol2qm74 8174 1 + + CC cord-015021-pol2qm74 8175 1 ratio ratio NN cord-015021-pol2qm74 8175 2 below below IN cord-015021-pol2qm74 8175 3 i i PRP cord-015021-pol2qm74 8175 4 were be VBD cord-015021-pol2qm74 8175 5 seen see VBN cord-015021-pol2qm74 8175 6 at at IN cord-015021-pol2qm74 8175 7 risk risk NN cord-015021-pol2qm74 8175 8 of of IN cord-015021-pol2qm74 8175 9 developing develop VBG cord-015021-pol2qm74 8175 10 septic septic JJ cord-015021-pol2qm74 8175 11 complications complication NNS cord-015021-pol2qm74 8175 12 . . . cord-015021-pol2qm74 8176 1 In in IN cord-015021-pol2qm74 8176 2 contrast contrast NN cord-015021-pol2qm74 8176 3 , , , cord-015021-pol2qm74 8176 4 a a DT cord-015021-pol2qm74 8176 5 percentage percentage NN cord-015021-pol2qm74 8176 6 of of IN cord-015021-pol2qm74 8176 7 monocytes monocyte NNS cord-015021-pol2qm74 8176 8 of of IN cord-015021-pol2qm74 8176 9 30 30 CD cord-015021-pol2qm74 8176 10 % % NN cord-015021-pol2qm74 8176 11 or or CC cord-015021-pol2qm74 8176 12 more more JJR cord-015021-pol2qm74 8176 13 among among IN cord-015021-pol2qm74 8176 14 total total JJ cord-015021-pol2qm74 8176 15 mononuclear mononuclear JJ cord-015021-pol2qm74 8176 16 cells cell NNS cord-015021-pol2qm74 8176 17 indicated indicate VBD cord-015021-pol2qm74 8176 18 an an DT cord-015021-pol2qm74 8176 19 uncomplicated uncomplicated JJ cord-015021-pol2qm74 8176 20 course course NN cord-015021-pol2qm74 8176 21 , , , cord-015021-pol2qm74 8176 22 in in IN cord-015021-pol2qm74 8176 23 general general JJ cord-015021-pol2qm74 8176 24 . . . cord-015021-pol2qm74 8177 1 Conclusions conclusion NNS cord-015021-pol2qm74 8177 2 : : : cord-015021-pol2qm74 8178 1 The the DT cord-015021-pol2qm74 8178 2 immune immune JJ cord-015021-pol2qm74 8178 3 status status NN cord-015021-pol2qm74 8178 4 of of IN cord-015021-pol2qm74 8178 5 the the DT cord-015021-pol2qm74 8178 6 individual individual JJ cord-015021-pol2qm74 8178 7 patient patient NN cord-015021-pol2qm74 8178 8 may may MD cord-015021-pol2qm74 8178 9 significantly significantly RB cord-015021-pol2qm74 8178 10 influence influence VB cord-015021-pol2qm74 8178 11 the the DT cord-015021-pol2qm74 8178 12 course course NN cord-015021-pol2qm74 8178 13 of of IN cord-015021-pol2qm74 8178 14 acute acute JJ cord-015021-pol2qm74 8178 15 pancreatitis pancreatitis NN cord-015021-pol2qm74 8178 16 . . . cord-015021-pol2qm74 8179 1 The the DT cord-015021-pol2qm74 8179 2 cytokine cytokine NN cord-015021-pol2qm74 8179 3 pattern pattern NN cord-015021-pol2qm74 8179 4 in in IN cord-015021-pol2qm74 8179 5 peripheral peripheral JJ cord-015021-pol2qm74 8179 6 blood blood NN cord-015021-pol2qm74 8179 7 is be VBZ cord-015021-pol2qm74 8179 8 very very RB cord-015021-pol2qm74 8179 9 complex complex JJ cord-015021-pol2qm74 8179 10 and and CC cord-015021-pol2qm74 8179 11 most most JJS cord-015021-pol2qm74 8179 12 parameters parameter NNS cord-015021-pol2qm74 8179 13 are be VBP cord-015021-pol2qm74 8179 14 of of IN cord-015021-pol2qm74 8179 15 little little JJ cord-015021-pol2qm74 8179 16 use use NN cord-015021-pol2qm74 8179 17 for for IN cord-015021-pol2qm74 8179 18 the the DT cord-015021-pol2qm74 8179 19 clinician clinician NN cord-015021-pol2qm74 8179 20 . . . cord-015021-pol2qm74 8180 1 The the DT cord-015021-pol2qm74 8180 2 PMN pmn NN cord-015021-pol2qm74 8180 3 - - HYPH cord-015021-pol2qm74 8180 4 elastase elastase NN cord-015021-pol2qm74 8180 5 , , , cord-015021-pol2qm74 8180 6 IL-6 IL-6 NNP cord-015021-pol2qm74 8180 7 and and CC cord-015021-pol2qm74 8180 8 IL-8 IL-8 NNP cord-015021-pol2qm74 8180 9 , , , cord-015021-pol2qm74 8180 10 however however RB cord-015021-pol2qm74 8180 11 , , , cord-015021-pol2qm74 8180 12 closely closely RB cord-015021-pol2qm74 8180 13 correlate correlate VB cord-015021-pol2qm74 8180 14 to to IN cord-015021-pol2qm74 8180 15 the the DT cord-015021-pol2qm74 8180 16 clinical clinical JJ cord-015021-pol2qm74 8180 17 course course NN cord-015021-pol2qm74 8180 18 and and CC cord-015021-pol2qm74 8180 19 may may MD cord-015021-pol2qm74 8180 20 prove prove VB cord-015021-pol2qm74 8180 21 valuable valuable JJ cord-015021-pol2qm74 8180 22 for for IN cord-015021-pol2qm74 8180 23 follow follow NN cord-015021-pol2qm74 8180 24 - - HYPH cord-015021-pol2qm74 8180 25 up up NN cord-015021-pol2qm74 8180 26 . . . cord-015021-pol2qm74 8181 1 The the DT cord-015021-pol2qm74 8181 2 CD4+/CD8 cd4+/cd8 NN cord-015021-pol2qm74 8181 3 + + CC cord-015021-pol2qm74 8181 4 ratio ratio NN cord-015021-pol2qm74 8181 5 was be VBD cord-015021-pol2qm74 8181 6 found find VBN cord-015021-pol2qm74 8181 7 the the DT cord-015021-pol2qm74 8181 8 best good JJS cord-015021-pol2qm74 8181 9 predictor predictor NN cord-015021-pol2qm74 8181 10 of of IN cord-015021-pol2qm74 8181 11 septic septic JJ cord-015021-pol2qm74 8181 12 complications complication NNS cord-015021-pol2qm74 8181 13 , , , cord-015021-pol2qm74 8181 14 but but CC cord-015021-pol2qm74 8181 15 it -PRON- PRP cord-015021-pol2qm74 8181 16 failed fail VBD cord-015021-pol2qm74 8181 17 in in IN cord-015021-pol2qm74 8181 18 non non JJ cord-015021-pol2qm74 8181 19 - - JJ cord-015021-pol2qm74 8181 20 septic septic JJ cord-015021-pol2qm74 8181 21 patients patient NNS cord-015021-pol2qm74 8181 22 . . . cord-015021-pol2qm74 8182 1 A a DT cord-015021-pol2qm74 8182 2 percentage percentage NN cord-015021-pol2qm74 8182 3 of of IN cord-015021-pol2qm74 8182 4 30 30 CD cord-015021-pol2qm74 8182 5 % % NN cord-015021-pol2qm74 8182 6 or or CC cord-015021-pol2qm74 8182 7 more more JJR cord-015021-pol2qm74 8182 8 of of IN cord-015021-pol2qm74 8182 9 monocytes monocyte NNS cord-015021-pol2qm74 8182 10 among among IN cord-015021-pol2qm74 8182 11 total total JJ cord-015021-pol2qm74 8182 12 mononuclear mononuclear JJ cord-015021-pol2qm74 8182 13 ceils ceil NNS cord-015021-pol2qm74 8182 14 indicated indicate VBD cord-015021-pol2qm74 8182 15 a a DT cord-015021-pol2qm74 8182 16 rather rather RB cord-015021-pol2qm74 8182 17 mild mild JJ cord-015021-pol2qm74 8182 18 course course NN cord-015021-pol2qm74 8182 19 . . . cord-015021-pol2qm74 8183 1 The the DT cord-015021-pol2qm74 8183 2 reduced reduce VBN cord-015021-pol2qm74 8183 3 ability ability NN cord-015021-pol2qm74 8183 4 of of IN cord-015021-pol2qm74 8183 5 the the DT cord-015021-pol2qm74 8183 6 PMNs pmn NNS cord-015021-pol2qm74 8183 7 to to TO cord-015021-pol2qm74 8183 8 produce produce VB cord-015021-pol2qm74 8183 9 hydroxyl hydroxyl NN cord-015021-pol2qm74 8183 10 radicals radical NNS cord-015021-pol2qm74 8183 11 may may MD cord-015021-pol2qm74 8183 12 help help VB cord-015021-pol2qm74 8183 13 to to TO cord-015021-pol2qm74 8183 14 explain explain VB cord-015021-pol2qm74 8183 15 the the DT cord-015021-pol2qm74 8183 16 frequent frequent JJ cord-015021-pol2qm74 8183 17 development development NN cord-015021-pol2qm74 8183 18 of of IN cord-015021-pol2qm74 8183 19 septic septic JJ cord-015021-pol2qm74 8183 20 complications complication NNS cord-015021-pol2qm74 8183 21 in in IN cord-015021-pol2qm74 8183 22 severe severe JJ cord-015021-pol2qm74 8183 23 necmtizing necmtize VBG cord-015021-pol2qm74 8183 24 pancreatitis pancreatitis NN cord-015021-pol2qm74 8183 25 . . . cord-015021-pol2qm74 8184 1 Peroxidation peroxidation NN cord-015021-pol2qm74 8184 2 of of IN cord-015021-pol2qm74 8184 3 membrane membrane NN cord-015021-pol2qm74 8184 4 lipids lipid NNS cord-015021-pol2qm74 8184 5 contributes contribute VBZ cord-015021-pol2qm74 8184 6 to to IN cord-015021-pol2qm74 8184 7 ceil ceil NN cord-015021-pol2qm74 8184 8 injury injury NN cord-015021-pol2qm74 8184 9 in in IN cord-015021-pol2qm74 8184 10 pancreatitis pancreatitis NN cord-015021-pol2qm74 8184 11 . . . cord-015021-pol2qm74 8185 1 Overwhelming overwhelming JJ cord-015021-pol2qm74 8185 2 release release NN cord-015021-pol2qm74 8185 3 of of IN cord-015021-pol2qm74 8185 4 toxic toxic JJ cord-015021-pol2qm74 8185 5 metabolites metabolite NNS cord-015021-pol2qm74 8185 6 by by IN cord-015021-pol2qm74 8185 7 infiltrating infiltrate VBG cord-015021-pol2qm74 8185 8 neutrophils neutrophil NNS cord-015021-pol2qm74 8185 9 is be VBZ cord-015021-pol2qm74 8185 10 regarded regard VBN cord-015021-pol2qm74 8185 11 a a DT cord-015021-pol2qm74 8185 12 major major JJ cord-015021-pol2qm74 8185 13 pathogenetic pathogenetic JJ cord-015021-pol2qm74 8185 14 factor factor NN cord-015021-pol2qm74 8185 15 , , , cord-015021-pol2qm74 8185 16 too too RB cord-015021-pol2qm74 8185 17 . . . cord-015021-pol2qm74 8186 1 As as IN cord-015021-pol2qm74 8186 2 yet yet RB cord-015021-pol2qm74 8186 3 little little JJ cord-015021-pol2qm74 8186 4 is be VBZ cord-015021-pol2qm74 8186 5 known know VBN cord-015021-pol2qm74 8186 6 about about IN cord-015021-pol2qm74 8186 7 the the DT cord-015021-pol2qm74 8186 8 mechanisms mechanism NNS cord-015021-pol2qm74 8186 9 by by IN cord-015021-pol2qm74 8186 10 which which WDT cord-015021-pol2qm74 8186 11 oxidative oxidative JJ cord-015021-pol2qm74 8186 12 stress stress NN cord-015021-pol2qm74 8186 13 and and CC cord-015021-pol2qm74 8186 14 leukocytes leukocyte NNS cord-015021-pol2qm74 8186 15 damage damage NN cord-015021-pol2qm74 8186 16 pancreatic pancreatic NN cord-015021-pol2qm74 8186 17 cells cell NNS cord-015021-pol2qm74 8186 18 . . . cord-015021-pol2qm74 8187 1 The the DT cord-015021-pol2qm74 8187 2 present present JJ cord-015021-pol2qm74 8187 3 study study NN cord-015021-pol2qm74 8187 4 examines examine VBZ cord-015021-pol2qm74 8188 1 ( ( -LRB- cord-015021-pol2qm74 8188 2 I i NN cord-015021-pol2qm74 8188 3 ) ) -RRB- cord-015021-pol2qm74 8189 1 the the DT cord-015021-pol2qm74 8189 2 susceptibility susceptibility NN cord-015021-pol2qm74 8189 3 of of IN cord-015021-pol2qm74 8189 4 pancreatic pancreatic JJ cord-015021-pol2qm74 8189 5 acinar acinar NN cord-015021-pol2qm74 8189 6 cells cell NNS cord-015021-pol2qm74 8189 7 to to IN cord-015021-pol2qm74 8189 8 attacks attack NNS cord-015021-pol2qm74 8189 9 by by IN cord-015021-pol2qm74 8189 10 oxidants oxidant NNS cord-015021-pol2qm74 8189 11 and and CC cord-015021-pol2qm74 8189 12 leukocytes leukocyte NNS cord-015021-pol2qm74 8189 13 and and CC cord-015021-pol2qm74 8189 14 ( ( -LRB- cord-015021-pol2qm74 8189 15 2 2 LS cord-015021-pol2qm74 8189 16 ) ) -RRB- cord-015021-pol2qm74 8189 17 the the DT cord-015021-pol2qm74 8189 18 potential potential NN cord-015021-pol2qm74 8189 19 of of IN cord-015021-pol2qm74 8189 20 antioxidants antioxidant NNS cord-015021-pol2qm74 8189 21 to to TO cord-015021-pol2qm74 8189 22 prevent prevent VB cord-015021-pol2qm74 8189 23 such such JJ cord-015021-pol2qm74 8189 24 damage damage NN cord-015021-pol2qm74 8189 25 in in IN cord-015021-pol2qm74 8189 26 order order NN cord-015021-pol2qm74 8189 27 to to TO cord-015021-pol2qm74 8189 28 better better RB cord-015021-pol2qm74 8189 29 understand understand VB cord-015021-pol2qm74 8189 30 the the DT cord-015021-pol2qm74 8189 31 cellular cellular JJ cord-015021-pol2qm74 8189 32 mechanisms mechanism NNS cord-015021-pol2qm74 8189 33 of of IN cord-015021-pol2qm74 8189 34 pancreatic pancreatic JJ cord-015021-pol2qm74 8189 35 injury injury NN cord-015021-pol2qm74 8189 36 in in IN cord-015021-pol2qm74 8189 37 inflammatory inflammatory JJ cord-015021-pol2qm74 8189 38 states state NNS cord-015021-pol2qm74 8189 39 . . . cord-015021-pol2qm74 8190 1 Methods method NNS cord-015021-pol2qm74 8190 2 : : : cord-015021-pol2qm74 8190 3 Freshly freshly RB cord-015021-pol2qm74 8190 4 isolated isolate VBN cord-015021-pol2qm74 8190 5 rat rat NN cord-015021-pol2qm74 8190 6 pancreatic pancreatic JJ cord-015021-pol2qm74 8190 7 acinar acinar NNP cord-015021-pol2qm74 8190 8 ceils ceil NNS cord-015021-pol2qm74 8190 9 were be VBD cord-015021-pol2qm74 8190 10 exposed expose VBN cord-015021-pol2qm74 8190 11 to to IN cord-015021-pol2qm74 8190 12 a a DT cord-015021-pol2qm74 8190 13 model model NN cord-015021-pol2qm74 8190 14 system system NN cord-015021-pol2qm74 8190 15 of of IN cord-015021-pol2qm74 8190 16 oxidative oxidative JJ cord-015021-pol2qm74 8190 17 stress stress NN cord-015021-pol2qm74 8190 18 consisting consist VBG cord-015021-pol2qm74 8190 19 of of IN cord-015021-pol2qm74 8190 20 20 20 CD cord-015021-pol2qm74 8190 21 mU mU NNS cord-015021-pol2qm74 8190 22 / / SYM cord-015021-pol2qm74 8190 23 ml ml NN cord-015021-pol2qm74 8190 24 xanthine xanthine NN cord-015021-pol2qm74 8190 25 oxidase oxidase NN cord-015021-pol2qm74 8190 26 ( ( -LRB- cord-015021-pol2qm74 8190 27 XOD XOD NNP cord-015021-pol2qm74 8190 28 ) ) -RRB- cord-015021-pol2qm74 8190 29 , , , cord-015021-pol2qm74 8190 30 500 500 CD cord-015021-pol2qm74 8190 31 mM mm CD cord-015021-pol2qm74 8190 32 hypoxanthine hypoxanthine NN cord-015021-pol2qm74 8190 33 ( ( -LRB- cord-015021-pol2qm74 8190 34 HX HX NNP cord-015021-pol2qm74 8190 35 ) ) -RRB- cord-015021-pol2qm74 8190 36 , , , cord-015021-pol2qm74 8190 37 50 50 CD cord-015021-pol2qm74 8190 38 mM mm CD cord-015021-pol2qm74 8190 39 FeC13 FeC13 NNS cord-015021-pol2qm74 8190 40 and and CC cord-015021-pol2qm74 8190 41 75 75 CD cord-015021-pol2qm74 8190 42 mM mm CD cord-015021-pol2qm74 8190 43 EDTA edta NN cord-015021-pol2qm74 8190 44 . . . cord-015021-pol2qm74 8191 1 In in IN cord-015021-pol2qm74 8191 2 a a DT cord-015021-pol2qm74 8191 3 second second JJ cord-015021-pol2qm74 8191 4 set set NN cord-015021-pol2qm74 8191 5 of of IN cord-015021-pol2qm74 8191 6 experiments experiment NNS cord-015021-pol2qm74 8191 7 , , , cord-015021-pol2qm74 8191 8 acinar acinar NN cord-015021-pol2qm74 8191 9 cells cell NNS cord-015021-pol2qm74 8191 10 were be VBD cord-015021-pol2qm74 8191 11 exposed expose VBN cord-015021-pol2qm74 8191 12 to to IN cord-015021-pol2qm74 8191 13 excess excess JJ cord-015021-pol2qm74 8191 14 autologous autologous JJ cord-015021-pol2qm74 8191 15 neutrophils neutrophil NNS cord-015021-pol2qm74 8191 16 or or CC cord-015021-pol2qm74 8191 17 neutrophils neutrophil NNS cord-015021-pol2qm74 8191 18 obtained obtain VBN cord-015021-pol2qm74 8191 19 from from IN cord-015021-pol2qm74 8191 20 patients patient NNS cord-015021-pol2qm74 8191 21 with with IN cord-015021-pol2qm74 8191 22 acute acute JJ cord-015021-pol2qm74 8191 23 pancreatitis pancreatitis NN cord-015021-pol2qm74 8191 24 . . . cord-015021-pol2qm74 8192 1 Neutrophils neutrophil NNS cord-015021-pol2qm74 8192 2 were be VBD cord-015021-pol2qm74 8192 3 stimulated stimulate VBN cord-015021-pol2qm74 8192 4 by by IN cord-015021-pol2qm74 8192 5 zymosan zymosan NNP cord-015021-pol2qm74 8192 6 A A NNP cord-015021-pol2qm74 8192 7 , , , cord-015021-pol2qm74 8192 8 PMA PMA NNP cord-015021-pol2qm74 8192 9 , , , cord-015021-pol2qm74 8192 10 and and CC cord-015021-pol2qm74 8192 11 IL-8 IL-8 NNP cord-015021-pol2qm74 8192 12 . . . cord-015021-pol2qm74 8193 1 Cell cell NN cord-015021-pol2qm74 8193 2 viability viability NN cord-015021-pol2qm74 8193 3 was be VBD cord-015021-pol2qm74 8193 4 assessed assess VBN cord-015021-pol2qm74 8193 5 by by IN cord-015021-pol2qm74 8193 6 both both DT cord-015021-pol2qm74 8193 7 cellular cellular JJ cord-015021-pol2qm74 8193 8 uptake uptake NN cord-015021-pol2qm74 8193 9 of of IN cord-015021-pol2qm74 8193 10 trypan trypan NNP cord-015021-pol2qm74 8193 11 blue blue NNP cord-015021-pol2qm74 8193 12 ( ( -LRB- cord-015021-pol2qm74 8193 13 TB TB NNP cord-015021-pol2qm74 8193 14 ) ) -RRB- cord-015021-pol2qm74 8193 15 and and CC cord-015021-pol2qm74 8193 16 by by IN cord-015021-pol2qm74 8193 17 release release NN cord-015021-pol2qm74 8193 18 of of IN cord-015021-pol2qm74 8193 19 LDH LDH NNP cord-015021-pol2qm74 8193 20 . . . cord-015021-pol2qm74 8194 1 Results result NNS cord-015021-pol2qm74 8194 2 : : : cord-015021-pol2qm74 8195 1 The the DT cord-015021-pol2qm74 8195 2 XOD XOD NNP cord-015021-pol2qm74 8195 3 / / SYM cord-015021-pol2qm74 8195 4 HX hx NN cord-015021-pol2qm74 8195 5 system system NN cord-015021-pol2qm74 8195 6 caused cause VBD cord-015021-pol2qm74 8195 7 a a DT cord-015021-pol2qm74 8195 8 time time NN cord-015021-pol2qm74 8195 9 - - HYPH cord-015021-pol2qm74 8195 10 dependent dependent JJ cord-015021-pol2qm74 8195 11 acinar acinar JJ cord-015021-pol2qm74 8195 12 cell cell NN cord-015021-pol2qm74 8195 13 injury injury NN cord-015021-pol2qm74 8195 14 . . . cord-015021-pol2qm74 8196 1 This this DT cord-015021-pol2qm74 8196 2 injury injury NN cord-015021-pol2qm74 8196 3 was be VBD cord-015021-pol2qm74 8196 4 effectively effectively RB cord-015021-pol2qm74 8196 5 prevented prevent VBN cord-015021-pol2qm74 8196 6 by by IN cord-015021-pol2qm74 8196 7 catalase catalase NN cord-015021-pol2qm74 8196 8 ( ( -LRB- cord-015021-pol2qm74 8196 9 CAT CAT NNP cord-015021-pol2qm74 8196 10 ) ) -RRB- cord-015021-pol2qm74 8196 11 and and CC cord-015021-pol2qm74 8196 12 gfutathione gfutathione NNP cord-015021-pol2qm74 8196 13 peroxidase peroxidase NN cord-015021-pol2qm74 8196 14 ( ( -LRB- cord-015021-pol2qm74 8196 15 GPx GPx NNS cord-015021-pol2qm74 8196 16 ) ) -RRB- cord-015021-pol2qm74 8196 17 . . . cord-015021-pol2qm74 8197 1 In in IN cord-015021-pol2qm74 8197 2 comrast comrast JJ cord-015021-pol2qm74 8197 3 , , , cord-015021-pol2qm74 8197 4 superoxide superoxide NN cord-015021-pol2qm74 8197 5 dismutase dismutase NN cord-015021-pol2qm74 8197 6 ( ( -LRB- cord-015021-pol2qm74 8197 7 SOD SOD NNP cord-015021-pol2qm74 8197 8 ) ) -RRB- cord-015021-pol2qm74 8197 9 enhanced enhance VBN cord-015021-pol2qm74 8197 10 cell cell NN cord-015021-pol2qm74 8197 11 injury injury NN cord-015021-pol2qm74 8197 12 . . . cord-015021-pol2qm74 8198 1 Addition addition NN cord-015021-pol2qm74 8198 2 of of IN cord-015021-pol2qm74 8198 3 both both DT cord-015021-pol2qm74 8198 4 SOD SOD NNP cord-015021-pol2qm74 8198 5 and and CC cord-015021-pol2qm74 8198 6 CAT CAT NNP cord-015021-pol2qm74 8198 7 abolished abolish VBD cord-015021-pol2qm74 8198 8 the the DT cord-015021-pol2qm74 8198 9 damage damage NN cord-015021-pol2qm74 8198 10 seen see VBN cord-015021-pol2qm74 8198 11 with with IN cord-015021-pol2qm74 8198 12 SOD SOD NNP cord-015021-pol2qm74 8198 13 alone alone RB cord-015021-pol2qm74 8198 14 . . . cord-015021-pol2qm74 8199 1 The the DT cord-015021-pol2qm74 8199 2 non non JJ cord-015021-pol2qm74 8199 3 - - JJ cord-015021-pol2qm74 8199 4 enzymatic enzymatic JJ cord-015021-pol2qm74 8199 5 scavengers scavenger NNS cord-015021-pol2qm74 8199 6 mannitol mannitol NN cord-015021-pol2qm74 8199 7 , , , cord-015021-pol2qm74 8199 8 DMSO DMSO NNP cord-015021-pol2qm74 8199 9 , , , cord-015021-pol2qm74 8199 10 DMTU DMTU NNP cord-015021-pol2qm74 8199 11 and and CC cord-015021-pol2qm74 8199 12 the the DT cord-015021-pol2qm74 8199 13 iron iron NN cord-015021-pol2qm74 8199 14 chelator chelator NN cord-015021-pol2qm74 8199 15 deferoxamine deferoxamine NNP cord-015021-pol2qm74 8199 16 were be VBD cord-015021-pol2qm74 8199 17 not not RB cord-015021-pol2qm74 8199 18 protective protective JJ cord-015021-pol2qm74 8199 19 and and CC cord-015021-pol2qm74 8199 20 at at IN cord-015021-pol2qm74 8199 21 a a DT cord-015021-pol2qm74 8199 22 higher high JJR cord-015021-pol2qm74 8199 23 concentration concentration NN cord-015021-pol2qm74 8199 24 even even RB cord-015021-pol2qm74 8199 25 accelerated accelerate VBD cord-015021-pol2qm74 8199 26 cell cell NN cord-015021-pol2qm74 8199 27 decline decline NN cord-015021-pol2qm74 8199 28 . . . cord-015021-pol2qm74 8200 1 The the DT cord-015021-pol2qm74 8200 2 newly newly RB cord-015021-pol2qm74 8200 3 developed develop VBN cord-015021-pol2qm74 8200 4 antioxidants antioxidant NNS cord-015021-pol2qm74 8200 5 of of IN cord-015021-pol2qm74 8200 6 the the DT cord-015021-pol2qm74 8200 7 lazaroid lazaroid NNP cord-015021-pol2qm74 8200 8 type type NN cord-015021-pol2qm74 8200 9 effectively effectively RB cord-015021-pol2qm74 8200 10 prevented prevent VBD cord-015021-pol2qm74 8200 11 oxidative oxidative JJ cord-015021-pol2qm74 8200 12 acinar acinar JJ cord-015021-pol2qm74 8200 13 cell cell NN cord-015021-pol2qm74 8200 14 damage damage NN cord-015021-pol2qm74 8200 15 . . . cord-015021-pol2qm74 8201 1 Stimulated stimulated JJ cord-015021-pol2qm74 8201 2 neutrophils neutrophil NNS cord-015021-pol2qm74 8201 3 , , , cord-015021-pol2qm74 8201 4 both both CC cord-015021-pol2qm74 8201 5 autologous autologous JJ cord-015021-pol2qm74 8201 6 and and CC cord-015021-pol2qm74 8201 7 heterologous heterologous JJ cord-015021-pol2qm74 8201 8 , , , cord-015021-pol2qm74 8201 9 did do VBD cord-015021-pol2qm74 8201 10 not not RB cord-015021-pol2qm74 8201 11 damage damage VB cord-015021-pol2qm74 8201 12 healthy healthy JJ cord-015021-pol2qm74 8201 13 acinar acinar JJ cord-015021-pol2qm74 8201 14 cells cell NNS cord-015021-pol2qm74 8201 15 but but CC cord-015021-pol2qm74 8201 16 had have VBD cord-015021-pol2qm74 8201 17 even even RB cord-015021-pol2qm74 8201 18 protective protective JJ cord-015021-pol2qm74 8201 19 effects effect NNS cord-015021-pol2qm74 8201 20 . . . cord-015021-pol2qm74 8202 1 Conclusion conclusion NN cord-015021-pol2qm74 8202 2 : : : cord-015021-pol2qm74 8202 3 Pancreatic pancreatic JJ cord-015021-pol2qm74 8202 4 acinar acinar JJ cord-015021-pol2qm74 8202 5 ceils ceil NNS cord-015021-pol2qm74 8202 6 are be VBP cord-015021-pol2qm74 8202 7 very very RB cord-015021-pol2qm74 8202 8 susceptible susceptible JJ cord-015021-pol2qm74 8202 9 to to IN cord-015021-pol2qm74 8202 10 oxidative oxidative JJ cord-015021-pol2qm74 8202 11 injury injury NN cord-015021-pol2qm74 8202 12 . . . cord-015021-pol2qm74 8203 1 A a DT cord-015021-pol2qm74 8203 2 combination combination NN cord-015021-pol2qm74 8203 3 of of IN cord-015021-pol2qm74 8203 4 catalase catalase NN cord-015021-pol2qm74 8203 5 and and CC cord-015021-pol2qm74 8203 6 SOD SOD NNP cord-015021-pol2qm74 8203 7 prevented prevent VBD cord-015021-pol2qm74 8203 8 cell cell NN cord-015021-pol2qm74 8203 9 damage damage NN cord-015021-pol2qm74 8203 10 effectively effectively RB cord-015021-pol2qm74 8203 11 . . . cord-015021-pol2qm74 8204 1 SOD SOD NNP cord-015021-pol2qm74 8204 2 when when WRB cord-015021-pol2qm74 8204 3 given give VBN cord-015021-pol2qm74 8204 4 alone alone RB cord-015021-pol2qm74 8204 5 may may MD cord-015021-pol2qm74 8204 6 rather rather RB cord-015021-pol2qm74 8204 7 damage damage VB cord-015021-pol2qm74 8204 8 than than IN cord-015021-pol2qm74 8204 9 protect protect JJ cord-015021-pol2qm74 8204 10 aelnar aelnar NN cord-015021-pol2qm74 8204 11 cells cell NNS cord-015021-pol2qm74 8204 12 when when WRB cord-015021-pol2qm74 8204 13 H202 H202 NNP cord-015021-pol2qm74 8204 14 is be VBZ cord-015021-pol2qm74 8204 15 generated generate VBN cord-015021-pol2qm74 8204 16 in in IN cord-015021-pol2qm74 8204 17 concentrations concentration NNS cord-015021-pol2qm74 8204 18 overwhelming overwhelm VBG cord-015021-pol2qm74 8204 19 the the DT cord-015021-pol2qm74 8204 20 capacity capacity NN cord-015021-pol2qm74 8204 21 of of IN cord-015021-pol2qm74 8204 22 endogenous endogenous JJ cord-015021-pol2qm74 8204 23 catalase catalase NN cord-015021-pol2qm74 8204 24 . . . cord-015021-pol2qm74 8205 1 Therapeutic therapeutic JJ cord-015021-pol2qm74 8205 2 approaches approach NNS cord-015021-pol2qm74 8205 3 to to IN cord-015021-pol2qm74 8205 4 pancreatic pancreatic JJ cord-015021-pol2qm74 8205 5 disease disease NN cord-015021-pol2qm74 8205 6 using use VBG cord-015021-pol2qm74 8205 7 antioxidants antioxidant NNS cord-015021-pol2qm74 8205 8 should should MD cord-015021-pol2qm74 8205 9 , , , cord-015021-pol2qm74 8205 10 therefore therefore RB cord-015021-pol2qm74 8205 11 , , , cord-015021-pol2qm74 8205 12 include include VBP cord-015021-pol2qm74 8205 13 combinations combination NNS cord-015021-pol2qm74 8205 14 of of IN cord-015021-pol2qm74 8205 15 protective protective JJ cord-015021-pol2qm74 8205 16 substances substance NNS cord-015021-pol2qm74 8205 17 . . . cord-015021-pol2qm74 8206 1 The the DT cord-015021-pol2qm74 8206 2 lazaroids lazaroid NNS cord-015021-pol2qm74 8206 3 seem seem VBP cord-015021-pol2qm74 8206 4 to to TO cord-015021-pol2qm74 8206 5 be be VB cord-015021-pol2qm74 8206 6 candidates candidate NNS cord-015021-pol2qm74 8206 7 for for IN cord-015021-pol2qm74 8206 8 clinical clinical JJ cord-015021-pol2qm74 8206 9 use use NN cord-015021-pol2qm74 8206 10 as as IN cord-015021-pol2qm74 8206 11 antioxidants antioxidant NNS cord-015021-pol2qm74 8206 12 in in IN cord-015021-pol2qm74 8206 13 pancreatitis pancreatitis NN cord-015021-pol2qm74 8206 14 . . . cord-015021-pol2qm74 8207 1 The the DT cord-015021-pol2qm74 8207 2 results result NNS cord-015021-pol2qm74 8207 3 argue argue VBP cord-015021-pol2qm74 8207 4 against against IN cord-015021-pol2qm74 8207 5 direct direct JJ cord-015021-pol2qm74 8207 6 toxic toxic JJ cord-015021-pol2qm74 8207 7 effects effect NNS cord-015021-pol2qm74 8207 8 of of IN cord-015021-pol2qm74 8207 9 stimulated stimulated JJ cord-015021-pol2qm74 8207 10 neutrophils neutrophil NNS cord-015021-pol2qm74 8207 11 to to IN cord-015021-pol2qm74 8207 12 pancreatic pancreatic JJ cord-015021-pol2qm74 8207 13 acinar acinar NN cord-015021-pol2qm74 8207 14 cells cell NNS cord-015021-pol2qm74 8207 15 . . . cord-015021-pol2qm74 8208 1 are be VBP cord-015021-pol2qm74 8208 2 ch ch NNP cord-015021-pol2qm74 8208 3 ~ ~ CD cord-015021-pol2qm74 8208 4 act~ act~ NNP cord-015021-pol2qm74 8209 1 z~ z~ XX cord-015021-pol2qm74 8209 2 by by IN cord-015021-pol2qm74 8209 3 the the DT cord-015021-pol2qm74 8209 4 presence presence NN cord-015021-pol2qm74 8209 5 of of IN cord-015021-pol2qm74 8209 6 a a DT cord-015021-pol2qm74 8209 7 polymicrobial polymicrobial JJ cord-015021-pol2qm74 8209 8 flora flora NN cord-015021-pol2qm74 8210 1 , , , cord-015021-pol2qm74 8210 2 The the DT cord-015021-pol2qm74 8210 3 pmtotyI~ pmtotyi~ NN cord-015021-pol2qm74 8210 4 cffthese cffthese NN cord-015021-pol2qm74 8210 5 inf inf NNP cord-015021-pol2qm74 8210 6 ~ ~ NFP cord-015021-pol2qm74 8210 7 ons on NNS cord-015021-pol2qm74 8210 8 is be VBZ cord-015021-pol2qm74 8210 9 secend~,y secend~,y NNP cord-015021-pol2qm74 8210 10 bacterial bacterial JJ cord-015021-pol2qm74 8210 11 pedtonitlw pedtonitlw NN cord-015021-pol2qm74 8210 12 , , , cord-015021-pol2qm74 8210 13 whereby whereby WRB cord-015021-pol2qm74 8210 14 a a DT cord-015021-pol2qm74 8210 15 pathololoeal pathololoeal NN cord-015021-pol2qm74 8210 16 process process NN cord-015021-pol2qm74 8210 17 in in IN cord-015021-pol2qm74 8210 18 the the DT cord-015021-pol2qm74 8210 19 ~trointesfimd ~trointesfimd JJS cord-015021-pol2qm74 8210 20 tract tract NN cord-015021-pol2qm74 8210 21 r r NN cord-015021-pol2qm74 8210 22 ~ ~ NFP cord-015021-pol2qm74 8210 23 ful~ ful~ NNP cord-015021-pol2qm74 8210 24 in in IN cord-015021-pol2qm74 8210 25 tim tim NNP cord-015021-pol2qm74 8210 26 disrup disrup NNP cord-015021-pol2qm74 8210 27 ~ ~ NFP cord-015021-pol2qm74 8210 28 on on IN cord-015021-pol2qm74 8210 29 ofi~ ofi~ CD cord-015021-pol2qm74 8210 30 inteffrlty inteffrlty NN cord-015021-pol2qm74 8210 31 and and CC cord-015021-pol2qm74 8210 32 ¢ollseqtlent ¢ollseqtlent NN cord-015021-pol2qm74 8210 33 sptl]nge sptl]nge NNP cord-015021-pol2qm74 8210 34 of of IN cord-015021-pol2qm74 8210 35 inte~.i inte~.i NNP cord-015021-pol2qm74 8210 36 , , , cord-015021-pol2qm74 8210 37 o~.l o~.l IN cord-015021-pol2qm74 8210 38 gontents gontent NNS cord-015021-pol2qm74 8210 39 into into IN cord-015021-pol2qm74 8210 40 the the DT cord-015021-pol2qm74 8210 41 peritoneal peritoneal NN cord-015021-pol2qm74 8210 42 c c NN cord-015021-pol2qm74 8210 43 ~ ~ NFP cord-015021-pol2qm74 8210 44 iry iry NNP cord-015021-pol2qm74 8210 45 . . . cord-015021-pol2qm74 8211 1 The the DT cord-015021-pol2qm74 8211 2 ensuing ensue VBG cord-015021-pol2qm74 8211 3 infection infection NN cord-015021-pol2qm74 8211 4 invariably invariably RB cord-015021-pol2qm74 8211 5 contains contain VBZ cord-015021-pol2qm74 8211 6 a a DT cord-015021-pol2qm74 8211 7 mixtm~ mixtm~ NNP cord-015021-pol2qm74 8211 8 of of IN cord-015021-pol2qm74 8211 9 gt gt NNP cord-015021-pol2qm74 8211 10 ~ ~ NNP cord-015021-pol2qm74 8211 11 m m CD cord-015021-pol2qm74 8211 12 negative negative JJ cord-015021-pol2qm74 8211 13 enteric enteric JJ cord-015021-pol2qm74 8211 14 bacilli bacilli NN cord-015021-pol2qm74 8211 15 , , , cord-015021-pol2qm74 8211 16 gram gram NN cord-015021-pol2qm74 8211 17 positive positive JJ cord-015021-pol2qm74 8211 18 b b NNP cord-015021-pol2qm74 8211 19 ~ ~ NFP cord-015021-pol2qm74 8211 20 eria eria NNP cord-015021-pol2qm74 8211 21 and and CC cord-015021-pol2qm74 8211 22 anaerobe anaerobe NNP cord-015021-pol2qm74 8211 23 & & CC cord-015021-pol2qm74 8211 24 Experimental Experimental NNP cord-015021-pol2qm74 8211 25 and and CC cord-015021-pol2qm74 8211 26 clinical clinical JJ cord-015021-pol2qm74 8211 27 = = NN cord-015021-pol2qm74 8212 1 t t NNP cord-015021-pol2qm74 8213 1 ~ies ~ie NNS cord-015021-pol2qm74 8213 2 have have VBP cord-015021-pol2qm74 8213 3 de de NNP cord-015021-pol2qm74 8213 4 ~ ~ CD cord-015021-pol2qm74 8213 5 ed ed NN cord-015021-pol2qm74 8213 6 the the DT cord-015021-pol2qm74 8213 7 eantrlbution eantrlbution NN cord-015021-pol2qm74 8213 8 of of IN cord-015021-pol2qm74 8213 9 each each DT cord-015021-pol2qm74 8213 10 of of IN cord-015021-pol2qm74 8213 11 th¢~ th¢~ NN cord-015021-pol2qm74 8213 12 components component NNS cord-015021-pol2qm74 8213 13 to to IN cord-015021-pol2qm74 8213 14 ti~ ti~ JJ cord-015021-pol2qm74 8213 15 ovemU ovemu JJ cord-015021-pol2qm74 8213 16 virulence virulence NN cord-015021-pol2qm74 8213 17 of of IN cord-015021-pol2qm74 8213 18 these these DT cord-015021-pol2qm74 8213 19 in in IN cord-015021-pol2qm74 8213 20 ~ ~ CD cord-015021-pol2qm74 8213 21 ons on NNS cord-015021-pol2qm74 8213 22 , , , cord-015021-pol2qm74 8213 23 Gram Gram NNP cord-015021-pol2qm74 8213 24 negative negative JJ cord-015021-pol2qm74 8213 25 enteri~ enteri~ NNS cord-015021-pol2qm74 8213 26 such such JJ cord-015021-pol2qm74 8213 27 as as IN cord-015021-pol2qm74 8213 28 F.veher F.veher NNP cord-015021-pol2qm74 8214 1 ~chla ~chla NFP cord-015021-pol2qm74 8214 2 coil coil NN cord-015021-pol2qm74 8214 3 ere ere VBP cord-015021-pol2qm74 8214 4 endowed endow VBN cord-015021-pol2qm74 8214 5 with with IN cord-015021-pol2qm74 8214 6 a a DT cord-015021-pol2qm74 8214 7 virulent virulent JJ cord-015021-pol2qm74 8214 8 l l NN cord-015021-pol2qm74 8214 9 ~ ~ NFP cord-015021-pol2qm74 8214 10 l l NN cord-015021-pol2qm74 8214 11 ~ ~ CD cord-015021-pol2qm74 8214 12 x x . cord-015021-pol2qm74 8215 1 ~lyse ~lyse XX cord-015021-pol2qm74 8216 1 ~haride ~haride NNP cord-015021-pol2qm74 8216 2 ptill~ ptill~ XX cord-015021-pol2qm74 8217 1 ly ly NNP cord-015021-pol2qm74 8217 2 t t NNP cord-015021-pol2qm74 8217 3 ~ ~ CD cord-015021-pol2qm74 8217 4 sponsible sponsible NNP cord-015021-pol2qm74 8217 5 for for IN cord-015021-pol2qm74 8217 6 lethality lethality NN cord-015021-pol2qm74 8217 7 , , , cord-015021-pol2qm74 8218 1 By by IN cord-015021-pol2qm74 8218 2 contrast contrast NN cord-015021-pol2qm74 8218 3 , , , cord-015021-pol2qm74 8218 4 Bacteroldes Bacteroldes NNP cord-015021-pol2qm74 8218 5 sl sl NNP cord-015021-pol2qm74 8218 6 ~ ~ NFP cord-015021-pol2qm74 8218 7 cles cles NNP cord-015021-pol2qm74 8218 8 , , , cord-015021-pol2qm74 8218 9 which which WDT cord-015021-pol2qm74 8218 10 rarely rarely RB cord-015021-pol2qm74 8218 11 c c NNP cord-015021-pol2qm74 8218 12 ~ ~ NFP cord-015021-pol2qm74 8218 13 se se FW cord-015021-pol2qm74 8218 14 death death NN cord-015021-pol2qm74 8218 15 , , , cord-015021-pol2qm74 8218 16 prornot~ prornot~ NNP cord-015021-pol2qm74 8218 17 abscess abscess NN cord-015021-pol2qm74 8218 18 fOnllation fOnllation NNP cord-015021-pol2qm74 8218 19 , , , cord-015021-pol2qm74 8218 20 A a DT cord-015021-pol2qm74 8218 21 uniqm~ uniqm~ NN cord-015021-pol2qm74 8218 22 capsul~ capsul~ JJ cord-015021-pol2qm74 8218 23 polyseccluu'ide polyseccluu'ide NN cord-015021-pol2qm74 8218 24 , , , cord-015021-pol2qm74 8218 25 particularly particularly RB cord-015021-pol2qm74 8218 26 on on IN cord-015021-pol2qm74 8218 27 B.j B.j NNP cord-015021-pol2qm74 8218 28 ~ ~ CD cord-015021-pol2qm74 8218 29 ogilJs ogiljs CD cord-015021-pol2qm74 8218 30 slrai~ slrai~ NNP cord-015021-pol2qm74 8218 31 , , , cord-015021-pol2qm74 8218 32 oontributes oontribute NNS cord-015021-pol2qm74 8218 33 to to IN cord-015021-pol2qm74 8218 34 tJtis tJtis NNP cord-015021-pol2qm74 8218 35 erect erect VB cord-015021-pol2qm74 8218 36 , , , cord-015021-pol2qm74 8218 37 Several several JJ cord-015021-pol2qm74 8218 38 mecltanims mecltanim NNS cord-015021-pol2qm74 8218 39 have have VBP cord-015021-pol2qm74 8218 40 bccn bccn NNP cord-015021-pol2qm74 8218 41 pml~ pml~ XX cord-015021-pol2qm74 8219 1 ed ed NNP cord-015021-pol2qm74 8219 2 whereby whereby WRB cord-015021-pol2qm74 8219 3 or~ or~ NNP cord-015021-pol2qm74 8219 4 microorganism microorganism NNP cord-015021-pol2qm74 8219 5 mi mi NNP cord-015021-pol2qm74 8219 6 ~ ~ NFP cord-015021-pol2qm74 8219 7 t t XX cord-015021-pol2qm74 8219 8 interact interact VB cord-015021-pol2qm74 8219 9 with with IN cord-015021-pol2qm74 8219 10 its -PRON- PRP$ cord-015021-pol2qm74 8219 11 microbial microbial JJ cord-015021-pol2qm74 8219 12 ~net ~net NNP cord-015021-pol2qm74 8219 13 to to TO cord-015021-pol2qm74 8219 14 augment augment VB cord-015021-pol2qm74 8219 15 the the DT cord-015021-pol2qm74 8219 16 overall overall JJ cord-015021-pol2qm74 8219 17 virulence virulence NN cord-015021-pol2qm74 8219 18 of of IN cord-015021-pol2qm74 8219 19 a a DT cord-015021-pol2qm74 8219 20 r r NN cord-015021-pol2qm74 8219 21 ~ ~ NFP cord-015021-pol2qm74 8219 22 xed xed NN cord-015021-pol2qm74 8219 23 im im UH cord-015021-pol2qm74 8219 24 ~ ~ NFP cord-015021-pol2qm74 8219 25 edan edan NNP cord-015021-pol2qm74 8219 26 . . . cord-015021-pol2qm74 8220 1 These these DT cord-015021-pol2qm74 8220 2 include include VBP cord-015021-pol2qm74 8220 3 : : : cord-015021-pol2qm74 8220 4 l l NN cord-015021-pol2qm74 8220 5 ) ) -RRB- cord-015021-pol2qm74 8220 6 provision provision NN cord-015021-pol2qm74 8220 7 of of IN cord-015021-pol2qm74 8220 8 nutrients nutrient NNS cord-015021-pol2qm74 8220 9 by by IN cord-015021-pol2qm74 8220 10 one one CD cord-015021-pol2qm74 8220 11 apexes apex NNS cord-015021-pol2qm74 8220 12 which which WDT cord-015021-pol2qm74 8220 13 stimulates stimulate VBZ cord-015021-pol2qm74 8220 14 the the DT cord-015021-pol2qm74 8220 15 growth growth NN cord-015021-pol2qm74 8220 16 of of IN cord-015021-pol2qm74 8220 17 its -PRON- PRP$ cord-015021-pol2qm74 8220 18 ~opathoge ~opathoge NNP cord-015021-pol2qm74 8220 19 & & CC cord-015021-pol2qm74 8220 20 2 2 CD cord-015021-pol2qm74 8220 21 ) ) -RRB- cord-015021-pol2qm74 8220 22 inhibition inhibition NN cord-015021-pol2qm74 8220 23 of of IN cord-015021-pol2qm74 8220 24 host host NN cord-015021-pol2qm74 8220 25 deletes delete VBZ cord-015021-pol2qm74 8220 26 by by IN cord-015021-pol2qm74 8220 27 one one CD cord-015021-pol2qm74 8220 28 of of IN cord-015021-pol2qm74 8220 29 the the DT cord-015021-pol2qm74 8220 30 migroorganisms migroorganism NNS cord-015021-pol2qm74 8220 31 so so IN cord-015021-pol2qm74 8220 32 that that IN cord-015021-pol2qm74 8220 33 the the DT cord-015021-pol2qm74 8220 34 other other JJ cord-015021-pol2qm74 8220 35 microbes microbe NNS cord-015021-pol2qm74 8220 36 might may MD cord-015021-pol2qm74 8220 37 persist persist VB cord-015021-pol2qm74 8220 38 and and CC cord-015021-pol2qm74 8220 39 exert exert VB cord-015021-pol2qm74 8220 40 their -PRON- PRP$ cord-015021-pol2qm74 8220 41 virulence virulence NN cord-015021-pol2qm74 8220 42 , , , cord-015021-pol2qm74 8220 43 3 3 CD cord-015021-pol2qm74 8220 44 ) ) -RRB- cord-015021-pol2qm74 8220 45 the the DT cord-015021-pol2qm74 8220 46 trant~ trant~ NNP cord-015021-pol2qm74 8220 47 of of IN cord-015021-pol2qm74 8220 48 viM. viM. NNP cord-015021-pol2qm74 8220 49 © © NNP cord-015021-pol2qm74 8220 50 n n NN cord-015021-pol2qm74 8220 51 ~ ~ NFP cord-015021-pol2qm74 8220 52 e e LS cord-015021-pol2qm74 8220 53 traits trait NNS cord-015021-pol2qm74 8220 54 between between IN cord-015021-pol2qm74 8220 55 ~renr ~renr NNP cord-015021-pol2qm74 8220 56 ~ ~ NFP cord-015021-pol2qm74 8220 57 a a LS cord-015021-pol2qm74 8220 58 . . . cord-015021-pol2qm74 8220 59 ,dsms ,dsms , cord-015021-pol2qm74 8220 60 and and CC cord-015021-pol2qm74 8220 61 4 4 LS cord-015021-pol2qm74 8220 62 ) ) -RRB- cord-015021-pol2qm74 8221 1 the the DT cord-015021-pol2qm74 8221 2 ~.mizatian ~.mizatian CD cord-015021-pol2qm74 8221 3 d d XX cord-015021-pol2qm74 8222 1 the the DT cord-015021-pol2qm74 8222 2 mi mi NNP cord-015021-pol2qm74 8222 3 ~ ~ NNP cord-015021-pol2qm74 8222 4 oe oe NNP cord-015021-pol2qm74 8222 5 ~ ~ NFP cord-015021-pol2qm74 8222 6 vironmental vironmental NNP cord-015021-pol2qm74 8222 7 con con NNP cord-015021-pol2qm74 8222 8 ~ ~ CD cord-015021-pol2qm74 8222 9 tion$ tion$ NNP cord-015021-pol2qm74 8222 10 by by IN cord-015021-pol2qm74 8222 11 one one CD cord-015021-pol2qm74 8222 12 d d NN cord-015021-pol2qm74 8223 1 the the DT cord-015021-pol2qm74 8223 2 baetez'isl baetez'isl NNP cord-015021-pol2qm74 8223 3 pa pa NNP cord-015021-pol2qm74 8223 4 # # NNP cord-015021-pol2qm74 8223 5 , , , cord-015021-pol2qm74 8223 6 so so IN cord-015021-pol2qm74 8223 7 that that IN cord-015021-pol2qm74 8223 8 the the DT cord-015021-pol2qm74 8223 9 other other JJ cord-015021-pol2qm74 8223 10 might may MD cord-015021-pol2qm74 8223 11 persist persist VB cord-015021-pol2qm74 8223 12 . . . cord-015021-pol2qm74 8224 1 Exampl~ Exampl~ `` cord-015021-pol2qm74 8224 2 for for IN cord-015021-pol2qm74 8224 3 each each DT cord-015021-pol2qm74 8224 4 of of IN cord-015021-pol2qm74 8224 5 these these DT cord-015021-pol2qm74 8224 6 m m NN cord-015021-pol2qm74 8224 7 ~ ~ NFP cord-015021-pol2qm74 8224 8 banisms banism NNS cord-015021-pol2qm74 8224 9 Imv~ imv~ RB cord-015021-pol2qm74 8224 10 been be VBN cord-015021-pol2qm74 8224 11 provided provide VBN cord-015021-pol2qm74 8224 12 by by IN cord-015021-pol2qm74 8224 13 experimental experimental JJ cord-015021-pol2qm74 8224 14 ttudies ttudie NNS cord-015021-pol2qm74 8225 1 i i PRP cord-015021-pol2qm74 8225 2 ~ ~ NFP cord-015021-pol2qm74 8225 3 stigating stigate VBG cord-015021-pol2qm74 8225 4 E.co!l- e.co!l- NN cord-015021-pol2qm74 8226 1 B.p B.p NNP cord-015021-pol2qm74 8227 1 ~flls ~flls NNP cord-015021-pol2qm74 8227 2 synergistic synergistic JJ cord-015021-pol2qm74 8227 3 in in IN cord-015021-pol2qm74 8227 4 ~ ~ NFP cord-015021-pol2qm74 8227 5 ra ra NNP cord-015021-pol2qm74 8227 6 ~ ~ NNP cord-015021-pol2qm74 8227 7 ons on NNS cord-015021-pol2qm74 8227 8 . . . cord-015021-pol2qm74 8228 1 Byproducts byproduct NNS cord-015021-pol2qm74 8228 2 ofg.coli ofg.coli NNP cord-015021-pol2qm74 8228 3 metabolim metabolim NN cord-015021-pol2qm74 8228 4 l~¢ovide l~¢ovide NNP cord-015021-pol2qm74 8228 5 essential essential JJ cord-015021-pol2qm74 8228 6 short short JJ cord-015021-pol2qm74 8228 7 ebath ebath NNP cord-015021-pol2qm74 8228 8 fatty fatty JJ cord-015021-pol2qm74 8228 9 acids acid NNS cord-015021-pol2qm74 8229 1 £ £ $ cord-015021-pol2qm74 8229 2 ~ ~ NFP cord-015021-pol2qm74 8229 3 optimal optimal JJ cord-015021-pol2qm74 8229 4 B b NN cord-015021-pol2qm74 8229 5 , , , cord-015021-pol2qm74 8230 1 frosili~ frosili~ NNP cord-015021-pol2qm74 8230 2 ga'owth ga'owth NNP cord-015021-pol2qm74 8230 3 . . . cord-015021-pol2qm74 8231 1 Fm Fm NNP cord-015021-pol2qm74 8231 2 - - HYPH cord-015021-pol2qm74 8231 3 ther ther NNP cord-015021-pol2qm74 8231 4 , , , cord-015021-pol2qm74 8231 5 oxygen oxygen NN cord-015021-pol2qm74 8231 6 ¢ons ¢on NNS cord-015021-pol2qm74 8232 1 ~tmption ~tmption NNP cord-015021-pol2qm74 8232 2 by by IN cord-015021-pol2qm74 8232 3 Kcelt Kcelt NNP cord-015021-pol2qm74 8232 4 lowers lower VBZ cord-015021-pol2qm74 8232 5 oxygen oxygen NN cord-015021-pol2qm74 8232 6 tension tension NN cord-015021-pol2qm74 8232 7 end end NN cord-015021-pol2qm74 8232 8 redox redox NN cord-015021-pol2qm74 8232 9 potantial potantial NN cord-015021-pol2qm74 8232 10 to to IN cord-015021-pol2qm74 8232 11 levels level NNS cord-015021-pol2qm74 8232 12 eomlucive eomlucive NNS cord-015021-pol2qm74 8232 13 to to IN cord-015021-pol2qm74 8232 14 B#a#lts B#a#lts NNP cord-015021-pol2qm74 8232 15 gro gro NNP cord-015021-pol2qm74 8232 16 ~ ~ NFP cord-015021-pol2qm74 8232 17 h h NN cord-015021-pol2qm74 8232 18 . . . cord-015021-pol2qm74 8233 1 Coawr Coawr NNP cord-015021-pol2qm74 8233 2 ~ ~ NFP cord-015021-pol2qm74 8233 3 ely ely NNP cord-015021-pol2qm74 8233 4 , , , cord-015021-pol2qm74 8233 5 B,~agtlis B,~agtlis NNP cord-015021-pol2qm74 8233 6 rolea~ rolea~ NNP cord-015021-pol2qm74 8234 1 s s POS cord-015021-pol2qm74 8234 2 proteases protease NNS cord-015021-pol2qm74 8234 3 and and CC cord-015021-pol2qm74 8234 4 fatty fatty JJ cord-015021-pol2qm74 8234 5 acids acid NNS cord-015021-pol2qm74 8235 1 wl~¢h wl~¢h NNP cord-015021-pol2qm74 8235 2 impair impair VB cord-015021-pol2qm74 8235 3 pl'tsgocy~¢ pl'tsgocy~¢ NN cord-015021-pol2qm74 8236 1 ~lt ~lt NNP cord-015021-pol2qm74 8236 2 Rmctlon Rmctlon NNP cord-015021-pol2qm74 8236 3 tnd tnd NN cord-015021-pol2qm74 8236 4 permit permit VBP cord-015021-pol2qm74 8236 5 F- f- CD cord-015021-pol2qm74 8236 6 .. .. . cord-015021-pol2qm74 8237 1 ¢oli ¢oli CD cord-015021-pol2qm74 8238 1 proliferation proliferation NN cord-015021-pol2qm74 8238 2 and and CC cord-015021-pol2qm74 8238 3 expression expression NN cord-015021-pol2qm74 8238 4 of of IN cord-015021-pol2qm74 8238 5 its -PRON- PRP$ cord-015021-pol2qm74 8238 6 intrinsic intrinsic JJ cord-015021-pol2qm74 8238 7 virulent virulent NN cord-015021-pol2qm74 8238 8 . . . cord-015021-pol2qm74 8239 1 In in IN cord-015021-pol2qm74 8239 2 summaxy summaxy NNS cord-015021-pol2qm74 8239 3 , , , cord-015021-pol2qm74 8239 4 interactions interaction NNS cord-015021-pol2qm74 8239 5 among among IN cord-015021-pol2qm74 8239 6 the the DT cord-015021-pol2qm74 8239 7 separate separate JJ cord-015021-pol2qm74 8239 8 microbial microbial JJ cord-015021-pol2qm74 8239 9 cemponents cemponent NNS cord-015021-pol2qm74 8239 10 of of IN cord-015021-pol2qm74 8239 11 mixed mixed JJ cord-015021-pol2qm74 8239 12 infections infection NNS cord-015021-pol2qm74 8239 13 heighten heighten VBP cord-015021-pol2qm74 8239 14 the the DT cord-015021-pol2qm74 8239 15 overall overall JJ cord-015021-pol2qm74 8239 16 virttienee virttienee NN cord-015021-pol2qm74 8239 17 of of IN cord-015021-pol2qm74 8239 18 these these DT cord-015021-pol2qm74 8239 19 lafectiot~ lafectiot~ NNP cord-015021-pol2qm74 8239 20 , , , cord-015021-pol2qm74 8239 21 This this DT cord-015021-pol2qm74 8239 22 knowledge knowledge NN cord-015021-pol2qm74 8239 23 provides provide VBZ cord-015021-pol2qm74 8239 24 ~r ~r XX cord-015021-pol2qm74 8239 25 rationale rationale NN cord-015021-pol2qm74 8239 26 for for IN cord-015021-pol2qm74 8239 27 targetting targette VBG cord-015021-pol2qm74 8239 28 of of IN cord-015021-pol2qm74 8239 29 antibiotic antibiotic JJ cord-015021-pol2qm74 8239 30 therapy therapy NN cord-015021-pol2qm74 8239 31 against against IN cord-015021-pol2qm74 8239 32 the the DT cord-015021-pol2qm74 8239 33 knowa knowa NNP cord-015021-pol2qm74 8239 34 eantributors eantributor NNS cord-015021-pol2qm74 8239 35 of of IN cord-015021-pol2qm74 8239 36 these these DT cord-015021-pol2qm74 8239 37 synergistic synergistic JJ cord-015021-pol2qm74 8239 38 pro~¢sses pro~¢sse NNS cord-015021-pol2qm74 8239 39 , , , cord-015021-pol2qm74 8239 40 Intraabdominal intraabdominal JJ cord-015021-pol2qm74 8239 41 abscess abscess NN cord-015021-pol2qm74 8239 42 formation formation NN cord-015021-pol2qm74 8239 43 and and CC cord-015021-pol2qm74 8239 44 the the DT cord-015021-pol2qm74 8239 45 macrophage macrophage NN cord-015021-pol2qm74 8239 46 William William NNP cord-015021-pol2qm74 8239 47 G. G. NNP cord-015021-pol2qm74 8239 48 Cheadle Cheadle NNP cord-015021-pol2qm74 8239 49 , , , cord-015021-pol2qm74 8239 50 M.D. M.D. NNP cord-015021-pol2qm74 8239 51 , , , cord-015021-pol2qm74 8239 52 Department Department NNP cord-015021-pol2qm74 8239 53 of of IN cord-015021-pol2qm74 8239 54 Surgery Surgery NNP cord-015021-pol2qm74 8239 55 , , , cord-015021-pol2qm74 8239 56 University University NNP cord-015021-pol2qm74 8239 57 of of IN cord-015021-pol2qm74 8239 58 Louisville Louisville NNP cord-015021-pol2qm74 8239 59 School School NNP cord-015021-pol2qm74 8239 60 of of IN cord-015021-pol2qm74 8239 61 Medicine Medicine NNP cord-015021-pol2qm74 8239 62 , , , cord-015021-pol2qm74 8239 63 Louisville Louisville NNP cord-015021-pol2qm74 8239 64 , , , cord-015021-pol2qm74 8240 1 KY KY NNP cord-015021-pol2qm74 8240 2 40292 40292 CD cord-015021-pol2qm74 8240 3 Inflammation inflammation NN cord-015021-pol2qm74 8240 4 of of IN cord-015021-pol2qm74 8240 5 the the DT cord-015021-pol2qm74 8240 6 peritoneal peritoneal JJ cord-015021-pol2qm74 8240 7 cavity cavity NN cord-015021-pol2qm74 8240 8 following follow VBG cord-015021-pol2qm74 8240 9 bacterial bacterial JJ cord-015021-pol2qm74 8240 10 contamination contamination NN cord-015021-pol2qm74 8240 11 has have VBZ cord-015021-pol2qm74 8240 12 been be VBN cord-015021-pol2qm74 8240 13 classified classify VBN cord-015021-pol2qm74 8240 14 into into IN cord-015021-pol2qm74 8240 15 primary primary JJ cord-015021-pol2qm74 8240 16 , , , cord-015021-pol2qm74 8240 17 secondary secondary JJ cord-015021-pol2qm74 8240 18 and and CC cord-015021-pol2qm74 8240 19 tertiary tertiary JJ cord-015021-pol2qm74 8240 20 , , , cord-015021-pol2qm74 8240 21 the the DT cord-015021-pol2qm74 8240 22 last last JJ cord-015021-pol2qm74 8240 23 two two CD cord-015021-pol2qm74 8240 24 relating relate VBG cord-015021-pol2qm74 8240 25 to to IN cord-015021-pol2qm74 8240 26 bacteria bacteria NNS cord-015021-pol2qm74 8240 27 originating originate VBG cord-015021-pol2qm74 8240 28 from from IN cord-015021-pol2qm74 8240 29 the the DT cord-015021-pol2qm74 8240 30 gastrointestinal gastrointestinal JJ cord-015021-pol2qm74 8240 31 lumen lumen NN cord-015021-pol2qm74 8240 32 . . . cord-015021-pol2qm74 8241 1 The the DT cord-015021-pol2qm74 8241 2 natural natural JJ cord-015021-pol2qm74 8241 3 history history NN cord-015021-pol2qm74 8241 4 of of IN cord-015021-pol2qm74 8241 5 such such JJ cord-015021-pol2qm74 8241 6 infection infection NN cord-015021-pol2qm74 8241 7 is be VBZ cord-015021-pol2qm74 8241 8 either either DT cord-015021-pol2qm74 8241 9 resolution resolution NN cord-015021-pol2qm74 8241 10 without without IN cord-015021-pol2qm74 8241 11 clinical clinical JJ cord-015021-pol2qm74 8241 12 sequelae sequela NNS cord-015021-pol2qm74 8241 13 , , , cord-015021-pol2qm74 8241 14 which which WDT cord-015021-pol2qm74 8241 15 is be VBZ cord-015021-pol2qm74 8241 16 uncommon uncommon JJ cord-015021-pol2qm74 8241 17 , , , cord-015021-pol2qm74 8241 18 abscess abscess NN cord-015021-pol2qm74 8241 19 formation formation NN cord-015021-pol2qm74 8241 20 , , , cord-015021-pol2qm74 8241 21 or or CC cord-015021-pol2qm74 8241 22 generalized generalized JJ cord-015021-pol2qm74 8241 23 peritonitis peritonitis NN cord-015021-pol2qm74 8241 24 , , , cord-015021-pol2qm74 8241 25 which which WDT cord-015021-pol2qm74 8241 26 occurs occur VBZ cord-015021-pol2qm74 8241 27 as as IN cord-015021-pol2qm74 8241 28 a a DT cord-015021-pol2qm74 8241 29 result result NN cord-015021-pol2qm74 8241 30 of of IN cord-015021-pol2qm74 8241 31 failure failure NN cord-015021-pol2qm74 8241 32 of of IN cord-015021-pol2qm74 8241 33 peritoneal peritoneal JJ cord-015021-pol2qm74 8241 34 host host NN cord-015021-pol2qm74 8241 35 defenses defense NNS cord-015021-pol2qm74 8241 36 . . . cord-015021-pol2qm74 8242 1 Early early JJ cord-015021-pol2qm74 8242 2 clearance clearance NN cord-015021-pol2qm74 8242 3 of of IN cord-015021-pol2qm74 8242 4 microorganisms microorganism NNS cord-015021-pol2qm74 8242 5 by by IN cord-015021-pol2qm74 8242 6 peritoneal peritoneal JJ cord-015021-pol2qm74 8242 7 fluid fluid JJ cord-015021-pol2qm74 8242 8 circulation circulation NN cord-015021-pol2qm74 8242 9 and and CC cord-015021-pol2qm74 8242 10 filtration filtration NN cord-015021-pol2qm74 8242 11 througti througti NNP cord-015021-pol2qm74 8242 12 subdiaphragmatic subdiaphragmatic NNP cord-015021-pol2qm74 8242 13 lymphatics lymphatic NNS cord-015021-pol2qm74 8242 14 into into IN cord-015021-pol2qm74 8242 15 the the DT cord-015021-pol2qm74 8242 16 thoracic thoracic JJ cord-015021-pol2qm74 8242 17 duct duct NN cord-015021-pol2qm74 8242 18 and and CC cord-015021-pol2qm74 8242 19 systemic systemic JJ cord-015021-pol2qm74 8242 20 circulation circulation NN cord-015021-pol2qm74 8242 21 occurs occur VBZ cord-015021-pol2qm74 8242 22 as as RB cord-015021-pol2qm74 8242 23 well well RB cord-015021-pol2qm74 8242 24 . . . cord-015021-pol2qm74 8243 1 Simultaneously simultaneously RB cord-015021-pol2qm74 8243 2 peritoneal peritoneal JJ cord-015021-pol2qm74 8243 3 macrophages macrophage NNS cord-015021-pol2qm74 8243 4 and and CC cord-015021-pol2qm74 8243 5 the the DT cord-015021-pol2qm74 8243 6 omentum omentum NN cord-015021-pol2qm74 8243 7 approach approach NN cord-015021-pol2qm74 8243 8 the the DT cord-015021-pol2qm74 8243 9 area area NN cord-015021-pol2qm74 8243 10 of of IN cord-015021-pol2qm74 8243 11 inflammation inflammation NN cord-015021-pol2qm74 8243 12 and and CC cord-015021-pol2qm74 8243 13 lead lead NN cord-015021-pol2qm74 8243 14 to to IN cord-015021-pol2qm74 8243 15 neutrophil neutrophil NN cord-015021-pol2qm74 8243 16 influx influx NN cord-015021-pol2qm74 8243 17 and and CC cord-015021-pol2qm74 8243 18 abscess abscess NN cord-015021-pol2qm74 8243 19 formation formation NN cord-015021-pol2qm74 8243 20 adjacent adjacent JJ cord-015021-pol2qm74 8243 21 to to IN cord-015021-pol2qm74 8243 22 the the DT cord-015021-pol2qm74 8243 23 affected affected JJ cord-015021-pol2qm74 8243 24 viscus viscus NN cord-015021-pol2qm74 8243 25 . . . cord-015021-pol2qm74 8244 1 We -PRON- PRP cord-015021-pol2qm74 8244 2 have have VBP cord-015021-pol2qm74 8244 3 found find VBN cord-015021-pol2qm74 8244 4 a a DT cord-015021-pol2qm74 8244 5 shift shift NN cord-015021-pol2qm74 8244 6 in in IN cord-015021-pol2qm74 8244 7 peritoneal peritoneal JJ cord-015021-pol2qm74 8244 8 macrophage macrophage NN cord-015021-pol2qm74 8244 9 function function NN cord-015021-pol2qm74 8244 10 from from IN cord-015021-pol2qm74 8244 11 antigen antigen NN cord-015021-pol2qm74 8244 12 presentation presentation NN cord-015021-pol2qm74 8244 13 to to IN cord-015021-pol2qm74 8244 14 proinflarnmatory proinflarnmatory JJ cord-015021-pol2qm74 8244 15 cytokine cytokine JJ cord-015021-pol2qm74 8244 16 production production NN cord-015021-pol2qm74 8244 17 that that WDT cord-015021-pol2qm74 8244 18 occurs occur VBZ cord-015021-pol2qm74 8244 19 early early RB cord-015021-pol2qm74 8244 20 after after IN cord-015021-pol2qm74 8244 21 experimental experimental JJ cord-015021-pol2qm74 8244 22 peritonitis peritonitis NN cord-015021-pol2qm74 8244 23 produced produce VBN cord-015021-pol2qm74 8244 24 by by IN cord-015021-pol2qm74 8244 25 cecal cecal JJ cord-015021-pol2qm74 8244 26 ligation ligation NN cord-015021-pol2qm74 8244 27 and and CC cord-015021-pol2qm74 8244 28 puncture puncture NN cord-015021-pol2qm74 8244 29 . . . cord-015021-pol2qm74 8245 1 This this DT cord-015021-pol2qm74 8245 2 is be VBZ cord-015021-pol2qm74 8245 3 also also RB cord-015021-pol2qm74 8245 4 reflected reflect VBN cord-015021-pol2qm74 8245 5 by by IN cord-015021-pol2qm74 8245 6 reduced reduce VBN cord-015021-pol2qm74 8245 7 class class NN cord-015021-pol2qm74 8245 8 II II NNP cord-015021-pol2qm74 8245 9 histocompatibility histocompatibility NN cord-015021-pol2qm74 8245 10 antigen antigen NN cord-015021-pol2qm74 8245 11 expression expression NN cord-015021-pol2qm74 8245 12 on on IN cord-015021-pol2qm74 8245 13 peripheral peripheral JJ cord-015021-pol2qm74 8245 14 blood blood NN cord-015021-pol2qm74 8245 15 mononuclear mononuclear NN cord-015021-pol2qm74 8245 16 cells cell NNS cord-015021-pol2qm74 8245 17 and and CC cord-015021-pol2qm74 8245 18 peritoneal peritoneal JJ cord-015021-pol2qm74 8245 19 macrophages macrophage NNS cord-015021-pol2qm74 8245 20 . . . cord-015021-pol2qm74 8246 1 This this DT cord-015021-pol2qm74 8246 2 is be VBZ cord-015021-pol2qm74 8246 3 accempauied accempauie VBN cord-015021-pol2qm74 8246 4 by by IN cord-015021-pol2qm74 8246 5 an an DT cord-015021-pol2qm74 8246 6 influx influx NN cord-015021-pol2qm74 8246 7 of of IN cord-015021-pol2qm74 8246 8 both both DT cord-015021-pol2qm74 8246 9 neutrophils neutrophil NNS cord-015021-pol2qm74 8246 10 and and CC cord-015021-pol2qm74 8246 11 macrophages macrophage NNS cord-015021-pol2qm74 8246 12 into into IN cord-015021-pol2qm74 8246 13 the the DT cord-015021-pol2qm74 8246 14 peritoneum peritoneum NN cord-015021-pol2qm74 8246 15 and and CC cord-015021-pol2qm74 8246 16 subsequent subsequent JJ cord-015021-pol2qm74 8246 17 abscess abscess NN cord-015021-pol2qm74 8246 18 formation formation NN cord-015021-pol2qm74 8246 19 . . . cord-015021-pol2qm74 8247 1 Interestingly interestingly RB cord-015021-pol2qm74 8247 2 , , , cord-015021-pol2qm74 8247 3 there there EX cord-015021-pol2qm74 8247 4 is be VBZ cord-015021-pol2qm74 8247 5 little little JJ cord-015021-pol2qm74 8247 6 serum serum NN cord-015021-pol2qm74 8247 7 endotoxin endotoxin NN cord-015021-pol2qm74 8247 8 or or CC cord-015021-pol2qm74 8247 9 TNF TNF NNP cord-015021-pol2qm74 8247 10 seen see VBN cord-015021-pol2qm74 8247 11 in in IN cord-015021-pol2qm74 8247 12 this this DT cord-015021-pol2qm74 8247 13 model model NN cord-015021-pol2qm74 8247 14 despite despite IN cord-015021-pol2qm74 8247 15 TNF TNF NNP cord-015021-pol2qm74 8247 16 mRNA mRNA NNP cord-015021-pol2qm74 8247 17 expression expression NN cord-015021-pol2qm74 8247 18 in in IN cord-015021-pol2qm74 8247 19 peritoneal peritoneal JJ cord-015021-pol2qm74 8247 20 macrophages macrophage NNS cord-015021-pol2qm74 8247 21 . . . cord-015021-pol2qm74 8248 1 We -PRON- PRP cord-015021-pol2qm74 8248 2 believe believe VBP cord-015021-pol2qm74 8248 3 this this DT cord-015021-pol2qm74 8248 4 model model NN cord-015021-pol2qm74 8248 5 is be VBZ cord-015021-pol2qm74 8248 6 more more RBR cord-015021-pol2qm74 8248 7 clinically clinically RB cord-015021-pol2qm74 8248 8 relevant relevant JJ cord-015021-pol2qm74 8248 9 than than IN cord-015021-pol2qm74 8248 10 other other JJ cord-015021-pol2qm74 8248 11 models model NNS cord-015021-pol2qm74 8248 12 of of IN cord-015021-pol2qm74 8248 13 endotoxemia endotoxemia NN cord-015021-pol2qm74 8248 14 or or CC cord-015021-pol2qm74 8248 15 bacteremia bacteremia NN cord-015021-pol2qm74 8248 16 in in IN cord-015021-pol2qm74 8248 17 which which WDT cord-015021-pol2qm74 8248 18 different different JJ cord-015021-pol2qm74 8248 19 patterns pattern NNS cord-015021-pol2qm74 8248 20 of of IN cord-015021-pol2qm74 8248 21 cytokine cytokine JJ cord-015021-pol2qm74 8248 22 expression expression NN cord-015021-pol2qm74 8248 23 are be VBP cord-015021-pol2qm74 8248 24 seen see VBN cord-015021-pol2qm74 8248 25 . . . cord-015021-pol2qm74 8249 1 Newer new JJR cord-015021-pol2qm74 8249 2 agents agent NNS cord-015021-pol2qm74 8249 3 aimed aim VBN cord-015021-pol2qm74 8249 4 at at IN cord-015021-pol2qm74 8249 5 reduction reduction NN cord-015021-pol2qm74 8249 6 of of IN cord-015021-pol2qm74 8249 7 systemic systemic JJ cord-015021-pol2qm74 8249 8 manifestations manifestation NNS cord-015021-pol2qm74 8249 9 of of IN cord-015021-pol2qm74 8249 10 sepsis sepsis NN cord-015021-pol2qm74 8249 11 originating originate VBG cord-015021-pol2qm74 8249 12 from from IN cord-015021-pol2qm74 8249 13 intra intra JJ cord-015021-pol2qm74 8249 14 - - JJ cord-015021-pol2qm74 8249 15 abdominal abdominal JJ cord-015021-pol2qm74 8249 16 infection infection NN cord-015021-pol2qm74 8249 17 such such JJ cord-015021-pol2qm74 8249 18 as as IN cord-015021-pol2qm74 8249 19 monoclonal monoclonal JJ cord-015021-pol2qm74 8249 20 antibodies antibody NNS cord-015021-pol2qm74 8249 21 against against IN cord-015021-pol2qm74 8249 22 cytokines cytokine NNS cord-015021-pol2qm74 8249 23 or or CC cord-015021-pol2qm74 8249 24 IL-1 IL-1 NNP cord-015021-pol2qm74 8249 25 receptor receptor NN cord-015021-pol2qm74 8249 26 antagonists antagonist NNS cord-015021-pol2qm74 8249 27 may may MD cord-015021-pol2qm74 8249 28 need need VB cord-015021-pol2qm74 8249 29 to to TO cord-015021-pol2qm74 8249 30 be be VB cord-015021-pol2qm74 8249 31 directed direct VBN cord-015021-pol2qm74 8249 32 against against IN cord-015021-pol2qm74 8249 33 remote remote JJ cord-015021-pol2qm74 8249 34 organ organ NN cord-015021-pol2qm74 8249 35 macrophage macrophage NN cord-015021-pol2qm74 8249 36 populations population NNS cord-015021-pol2qm74 8249 37 while while IN cord-015021-pol2qm74 8249 38 preserving preserve VBG cord-015021-pol2qm74 8249 39 peritoneal peritoneal JJ cord-015021-pol2qm74 8249 40 macrophage macrophage NN cord-015021-pol2qm74 8249 41 function function NN cord-015021-pol2qm74 8249 42 . . . cord-015021-pol2qm74 8250 1 Inflammation inflammation NN cord-015021-pol2qm74 8250 2 is be VBZ cord-015021-pol2qm74 8250 3 a a DT cord-015021-pol2qm74 8250 4 complex complex JJ cord-015021-pol2qm74 8250 5 process process NN cord-015021-pol2qm74 8250 6 involving involve VBG cord-015021-pol2qm74 8250 7 microcirculatory microcirculatory JJ cord-015021-pol2qm74 8250 8 changes change NNS cord-015021-pol2qm74 8250 9 , , , cord-015021-pol2qm74 8250 10 extravasation extravasation NN cord-015021-pol2qm74 8250 11 of of IN cord-015021-pol2qm74 8250 12 fluid fluid NN cord-015021-pol2qm74 8250 13 and and CC cord-015021-pol2qm74 8250 14 a a DT cord-015021-pol2qm74 8250 15 cellular cellular JJ cord-015021-pol2qm74 8250 16 influx influx NN cord-015021-pol2qm74 8250 17 in in IN cord-015021-pol2qm74 8250 18 the the DT cord-015021-pol2qm74 8250 19 affected affect VBN cord-015021-pol2qm74 8250 20 body body NN cord-015021-pol2qm74 8250 21 area area NN cord-015021-pol2qm74 8250 22 . . . cord-015021-pol2qm74 8251 1 In in IN cord-015021-pol2qm74 8251 2 our -PRON- PRP$ cord-015021-pol2qm74 8251 3 communication communication NN cord-015021-pol2qm74 8251 4 , , , cord-015021-pol2qm74 8251 5 we -PRON- PRP cord-015021-pol2qm74 8251 6 will will MD cord-015021-pol2qm74 8251 7 only only RB cord-015021-pol2qm74 8251 8 consider consider VB cord-015021-pol2qm74 8251 9 the the DT cord-015021-pol2qm74 8251 10 regulation regulation NN cord-015021-pol2qm74 8251 11 of of IN cord-015021-pol2qm74 8251 12 the the DT cord-015021-pol2qm74 8251 13 cellular cellular JJ cord-015021-pol2qm74 8251 14 infiltrate infiltrate NN cord-015021-pol2qm74 8251 15 which which WDT cord-015021-pol2qm74 8251 16 plays play VBZ cord-015021-pol2qm74 8251 17 a a DT cord-015021-pol2qm74 8251 18 major major JJ cord-015021-pol2qm74 8251 19 role role NN cord-015021-pol2qm74 8251 20 in in IN cord-015021-pol2qm74 8251 21 the the DT cord-015021-pol2qm74 8251 22 defense defense NN cord-015021-pol2qm74 8251 23 of of IN cord-015021-pol2qm74 8251 24 the the DT cord-015021-pol2qm74 8251 25 peritoneum peritoneum NN cord-015021-pol2qm74 8251 26 against against IN cord-015021-pol2qm74 8251 27 microbial microbial JJ cord-015021-pol2qm74 8251 28 invasion invasion NN cord-015021-pol2qm74 8251 29 . . . cord-015021-pol2qm74 8252 1 Until until IN cord-015021-pol2qm74 8252 2 recently recently RB cord-015021-pol2qm74 8252 3 , , , cord-015021-pol2qm74 8252 4 it -PRON- PRP cord-015021-pol2qm74 8252 5 was be VBD cord-015021-pol2qm74 8252 6 thought think VBN cord-015021-pol2qm74 8252 7 that that IN cord-015021-pol2qm74 8252 8 the the DT cord-015021-pol2qm74 8252 9 influx influx NN cord-015021-pol2qm74 8252 10 of of IN cord-015021-pol2qm74 8252 11 leukocytes leukocyte NNS cord-015021-pol2qm74 8252 12 in in IN cord-015021-pol2qm74 8252 13 the the DT cord-015021-pol2qm74 8252 14 abdomen abdomen NN cord-015021-pol2qm74 8252 15 was be VBD cord-015021-pol2qm74 8252 16 induced induce VBN cord-015021-pol2qm74 8252 17 by by IN cord-015021-pol2qm74 8252 18 bacterial bacterial JJ cord-015021-pol2qm74 8252 19 products product NNS cord-015021-pol2qm74 8252 20 , , , cord-015021-pol2qm74 8252 21 local local JJ cord-015021-pol2qm74 8252 22 humeral humeral JJ cord-015021-pol2qm74 8252 23 factors factor NNS cord-015021-pol2qm74 8252 24 and and CC cord-015021-pol2qm74 8252 25 secretions secretion NNS cord-015021-pol2qm74 8252 26 of of IN cord-015021-pol2qm74 8252 27 resident resident JJ cord-015021-pol2qm74 8252 28 macrophages macrophage NNS cord-015021-pol2qm74 8252 29 . . . cord-015021-pol2qm74 8253 1 There there EX cord-015021-pol2qm74 8253 2 is be VBZ cord-015021-pol2qm74 8253 3 now now RB cord-015021-pol2qm74 8253 4 increasing increase VBG cord-015021-pol2qm74 8253 5 evidence evidence NN cord-015021-pol2qm74 8253 6 that that IN cord-015021-pol2qm74 8253 7 this this DT cord-015021-pol2qm74 8253 8 view view NN cord-015021-pol2qm74 8253 9 is be VBZ cord-015021-pol2qm74 8253 10 too too RB cord-015021-pol2qm74 8253 11 simplistic simplistic JJ cord-015021-pol2qm74 8253 12 . . . cord-015021-pol2qm74 8254 1 Many many JJ cord-015021-pol2qm74 8254 2 other other JJ cord-015021-pol2qm74 8254 3 cell cell NN cord-015021-pol2qm74 8254 4 types type NNS cord-015021-pol2qm74 8254 5 present present JJ cord-015021-pol2qm74 8254 6 in in IN cord-015021-pol2qm74 8254 7 the the DT cord-015021-pol2qm74 8254 8 abdominal abdominal JJ cord-015021-pol2qm74 8254 9 cavity cavity NN cord-015021-pol2qm74 8254 10 or or CC cord-015021-pol2qm74 8254 11 composing compose VBG cord-015021-pol2qm74 8254 12 the the DT cord-015021-pol2qm74 8254 13 peritoneal peritoneal JJ cord-015021-pol2qm74 8254 14 membrane membrane NN cord-015021-pol2qm74 8254 15 ( ( -LRB- cord-015021-pol2qm74 8254 16 mast mast NN cord-015021-pol2qm74 8254 17 - - HYPH cord-015021-pol2qm74 8254 18 cells cell NNS cord-015021-pol2qm74 8254 19 , , , cord-015021-pol2qm74 8254 20 mesothelial mesothelial JJ cord-015021-pol2qm74 8254 21 cells cell NNS cord-015021-pol2qm74 8254 22 , , , cord-015021-pol2qm74 8254 23 fibroblasts fibroblast NNS cord-015021-pol2qm74 8254 24 ) ) -RRB- cord-015021-pol2qm74 8254 25 are be VBP cord-015021-pol2qm74 8254 26 able able JJ cord-015021-pol2qm74 8254 27 to to TO cord-015021-pol2qm74 8254 28 release release VB cord-015021-pol2qm74 8254 29 or or CC cord-015021-pol2qm74 8254 30 secrete secrete VB cord-015021-pol2qm74 8254 31 vasoactive vasoactive JJ cord-015021-pol2qm74 8254 32 or or CC cord-015021-pol2qm74 8254 33 chemotactic chemotactic JJ cord-015021-pol2qm74 8254 34 substances substance NNS cord-015021-pol2qm74 8254 35 such such JJ cord-015021-pol2qm74 8254 36 as as IN cord-015021-pol2qm74 8254 37 histamine histamine NN cord-015021-pol2qm74 8254 38 , , , cord-015021-pol2qm74 8254 39 prostagtandines prostagtandine NNS cord-015021-pol2qm74 8254 40 , , , cord-015021-pol2qm74 8254 41 or or CC cord-015021-pol2qm74 8254 42 cytokines cytokine NNS cord-015021-pol2qm74 8254 43 . . . cord-015021-pol2qm74 8255 1 They -PRON- PRP cord-015021-pol2qm74 8255 2 are be VBP cord-015021-pol2qm74 8255 3 most most RBS cord-015021-pol2qm74 8255 4 likely likely JJ cord-015021-pol2qm74 8255 5 to to TO cord-015021-pol2qm74 8255 6 play play VB cord-015021-pol2qm74 8255 7 a a DT cord-015021-pol2qm74 8255 8 role role NN cord-015021-pol2qm74 8255 9 in in IN cord-015021-pol2qm74 8255 10 the the DT cord-015021-pol2qm74 8255 11 regulation regulation NN cord-015021-pol2qm74 8255 12 of of IN cord-015021-pol2qm74 8255 13 intraperitoneal intraperitoneal JJ cord-015021-pol2qm74 8255 14 inflammatory inflammatory JJ cord-015021-pol2qm74 8255 15 reactions reaction NNS cord-015021-pol2qm74 8255 16 . . . cord-015021-pol2qm74 8256 1 The the DT cord-015021-pol2qm74 8256 2 emigration emigration NN cord-015021-pol2qm74 8256 3 of of IN cord-015021-pol2qm74 8256 4 leukocytes leukocyte NNS cord-015021-pol2qm74 8256 5 towards towards IN cord-015021-pol2qm74 8256 6 the the DT cord-015021-pol2qm74 8256 7 abdominal abdominal JJ cord-015021-pol2qm74 8256 8 cavity cavity NN cord-015021-pol2qm74 8256 9 is be VBZ cord-015021-pol2qm74 8256 10 also also RB cord-015021-pol2qm74 8256 11 modulated modulate VBN cord-015021-pol2qm74 8256 12 by by IN cord-015021-pol2qm74 8256 13 a a DT cord-015021-pol2qm74 8256 14 previous previous JJ cord-015021-pol2qm74 8256 15 contact contact NN cord-015021-pol2qm74 8256 16 with with IN cord-015021-pol2qm74 8256 17 Gram Gram NNP cord-015021-pol2qm74 8256 18 negative negative JJ cord-015021-pol2qm74 8256 19 bacteria bacteria NNS cord-015021-pol2qm74 8256 20 . . . cord-015021-pol2qm74 8257 1 In in IN cord-015021-pol2qm74 8257 2 the the DT cord-015021-pol2qm74 8257 3 rat rat NN cord-015021-pol2qm74 8257 4 , , , cord-015021-pol2qm74 8257 5 this this DT cord-015021-pol2qm74 8257 6 intriguing intriguing JJ cord-015021-pol2qm74 8257 7 phenomenon phenomenon NN cord-015021-pol2qm74 8257 8 is be VBZ cord-015021-pol2qm74 8257 9 long long RB cord-015021-pol2qm74 8257 10 lasting last VBG cord-015021-pol2qm74 8257 11 , , , cord-015021-pol2qm74 8257 12 can can MD cord-015021-pol2qm74 8257 13 not not RB cord-015021-pol2qm74 8257 14 be be VB cord-015021-pol2qm74 8257 15 transferred transfer VBN cord-015021-pol2qm74 8257 16 by by IN cord-015021-pol2qm74 8257 17 serum serum NN cord-015021-pol2qm74 8257 18 and and CC cord-015021-pol2qm74 8257 19 seems seem VBZ cord-015021-pol2qm74 8257 20 independent independent JJ cord-015021-pol2qm74 8257 21 from from IN cord-015021-pol2qm74 8257 22 T T NNP cord-015021-pol2qm74 8257 23 lymphocytes lymphocyte NNS cord-015021-pol2qm74 8257 24 . . . cord-015021-pol2qm74 8258 1 The the DT cord-015021-pol2qm74 8258 2 clinical clinical JJ cord-015021-pol2qm74 8258 3 relevance relevance NN cord-015021-pol2qm74 8258 4 of of IN cord-015021-pol2qm74 8258 5 these these DT cord-015021-pol2qm74 8258 6 various various JJ cord-015021-pol2qm74 8258 7 regulating regulating NN cord-015021-pol2qm74 8258 8 mechanisms mechanism NNS cord-015021-pol2qm74 8258 9 has have VBZ cord-015021-pol2qm74 8258 10 still still RB cord-015021-pol2qm74 8258 11 to to TO cord-015021-pol2qm74 8258 12 be be VB cord-015021-pol2qm74 8258 13 determined determine VBN cord-015021-pol2qm74 8258 14 . . . cord-015021-pol2qm74 8259 1 Kinnaert Kinnaert NNP cord-015021-pol2qm74 8259 2 Paul Paul NNP cord-015021-pol2qm74 8259 3 , , , cord-015021-pol2qm74 8259 4 H6pital H6pital NNP cord-015021-pol2qm74 8259 5 Erasme Erasme NNP cord-015021-pol2qm74 8259 6 , , , cord-015021-pol2qm74 8259 7 Route Route NNP cord-015021-pol2qm74 8259 8 de de NNP cord-015021-pol2qm74 8259 9 Lennik Lennik NNP cord-015021-pol2qm74 8259 10 808 808 CD cord-015021-pol2qm74 8260 1 , , , cord-015021-pol2qm74 8260 2 1070 1070 CD cord-015021-pol2qm74 8260 3 Bruxelles Bruxelles NNP cord-015021-pol2qm74 8260 4 Belgium Belgium NNP cord-015021-pol2qm74 8260 5 Generalized generalized JJ cord-015021-pol2qm74 8260 6 response response NN cord-015021-pol2qm74 8260 7 in in IN cord-015021-pol2qm74 8260 8 secondary secondary JJ cord-015021-pol2qm74 8260 9 peritonitis peritonitis NN cord-015021-pol2qm74 8261 1 The the DT cord-015021-pol2qm74 8261 2 clinical clinical JJ cord-015021-pol2qm74 8261 3 course course NN cord-015021-pol2qm74 8261 4 of of IN cord-015021-pol2qm74 8261 5 an an DT cord-015021-pol2qm74 8261 6 intraabdominal intraabdominal JJ cord-015021-pol2qm74 8261 7 infection infection NN cord-015021-pol2qm74 8261 8 may may MD cord-015021-pol2qm74 8261 9 depend depend VB cord-015021-pol2qm74 8261 10 on on IN cord-015021-pol2qm74 8261 11 a a DT cord-015021-pol2qm74 8261 12 variety variety NN cord-015021-pol2qm74 8261 13 of of IN cord-015021-pol2qm74 8261 14 variables variable NNS cord-015021-pol2qm74 8261 15 including include VBG cord-015021-pol2qm74 8261 16 the the DT cord-015021-pol2qm74 8261 17 capacity capacity NN cord-015021-pol2qm74 8261 18 of of IN cord-015021-pol2qm74 8261 19 host host NN cord-015021-pol2qm74 8261 20 defense defense NN cord-015021-pol2qm74 8261 21 mechanisms mechanism NNS cord-015021-pol2qm74 8261 22 and and CC cord-015021-pol2qm74 8261 23 the the DT cord-015021-pol2qm74 8261 24 degree degree NN cord-015021-pol2qm74 8261 25 of of IN cord-015021-pol2qm74 8261 26 the the DT cord-015021-pol2qm74 8261 27 inflammatory inflammatory JJ cord-015021-pol2qm74 8261 28 response response NN cord-015021-pol2qm74 8261 29 . . . cord-015021-pol2qm74 8262 1 If if IN cord-015021-pol2qm74 8262 2 local local JJ cord-015021-pol2qm74 8262 3 defense defense NN cord-015021-pol2qm74 8262 4 mechanisms mechanism NNS cord-015021-pol2qm74 8262 5 fail fail VBP cord-015021-pol2qm74 8262 6 to to TO cord-015021-pol2qm74 8262 7 restrict restrict VB cord-015021-pol2qm74 8262 8 the the DT cord-015021-pol2qm74 8262 9 inflammation inflammation NN cord-015021-pol2qm74 8262 10 to to IN cord-015021-pol2qm74 8262 11 the the DT cord-015021-pol2qm74 8262 12 abdominal abdominal JJ cord-015021-pol2qm74 8262 13 cavity cavity NN cord-015021-pol2qm74 8262 14 a a DT cord-015021-pol2qm74 8262 15 generalized generalized JJ cord-015021-pol2qm74 8262 16 inflammatory inflammatory JJ cord-015021-pol2qm74 8262 17 reponse reponse NN cord-015021-pol2qm74 8262 18 will will MD cord-015021-pol2qm74 8262 19 result result VB cord-015021-pol2qm74 8262 20 . . . cord-015021-pol2qm74 8263 1 in in IN cord-015021-pol2qm74 8263 2 a a DT cord-015021-pol2qm74 8263 3 first first JJ cord-015021-pol2qm74 8263 4 stage stage NN cord-015021-pol2qm74 8263 5 generalized generalize VBN cord-015021-pol2qm74 8263 6 signs sign NNS cord-015021-pol2qm74 8263 7 of of IN cord-015021-pol2qm74 8263 8 a a DT cord-015021-pol2qm74 8263 9 local local JJ cord-015021-pol2qm74 8263 10 inflammation inflammation NN cord-015021-pol2qm74 8263 11 become become VBP cord-015021-pol2qm74 8263 12 detectable detectable JJ cord-015021-pol2qm74 8263 13 whereas whereas IN cord-015021-pol2qm74 8263 14 the the DT cord-015021-pol2qm74 8263 15 second second JJ cord-015021-pol2qm74 8263 16 stage stage NN cord-015021-pol2qm74 8263 17 comprises comprise VBZ cord-015021-pol2qm74 8263 18 the the DT cord-015021-pol2qm74 8263 19 overwhelming overwhelming JJ cord-015021-pol2qm74 8263 20 systemic systemic JJ cord-015021-pol2qm74 8263 21 inflammatory inflammatory JJ cord-015021-pol2qm74 8263 22 response response NN cord-015021-pol2qm74 8263 23 . . . cord-015021-pol2qm74 8264 1 The the DT cord-015021-pol2qm74 8264 2 extent extent NN cord-015021-pol2qm74 8264 3 of of IN cord-015021-pol2qm74 8264 4 this this DT cord-015021-pol2qm74 8264 5 systemic systemic JJ cord-015021-pol2qm74 8264 6 response response NN cord-015021-pol2qm74 8264 7 determines determine VBZ cord-015021-pol2qm74 8264 8 the the DT cord-015021-pol2qm74 8264 9 outcome outcome NN cord-015021-pol2qm74 8264 10 . . . cord-015021-pol2qm74 8265 1 Sometimes sometimes RB cord-015021-pol2qm74 8265 2 it -PRON- PRP cord-015021-pol2qm74 8265 3 may may MD cord-015021-pol2qm74 8265 4 appear appear VB cord-015021-pol2qm74 8265 5 to to TO cord-015021-pol2qm74 8265 6 be be VB cord-015021-pol2qm74 8265 7 unrelated unrelated JJ cord-015021-pol2qm74 8265 8 to to IN cord-015021-pol2qm74 8265 9 the the DT cord-015021-pol2qm74 8265 10 severity severity NN cord-015021-pol2qm74 8265 11 of of IN cord-015021-pol2qm74 8265 12 the the DT cord-015021-pol2qm74 8265 13 intraperitoneal intraperitoneal JJ cord-015021-pol2qm74 8265 14 findings finding NNS cord-015021-pol2qm74 8265 15 . . . cord-015021-pol2qm74 8266 1 The the DT cord-015021-pol2qm74 8266 2 activation activation NN cord-015021-pol2qm74 8266 3 of of IN cord-015021-pol2qm74 8266 4 plasma plasma NN cord-015021-pol2qm74 8266 5 systems system NNS cord-015021-pol2qm74 8266 6 and and CC cord-015021-pol2qm74 8266 7 cellular cellular JJ cord-015021-pol2qm74 8266 8 elements element NNS cord-015021-pol2qm74 8266 9 leads lead VBZ cord-015021-pol2qm74 8266 10 to to IN cord-015021-pol2qm74 8266 11 a a DT cord-015021-pol2qm74 8266 12 fast fast JJ cord-015021-pol2qm74 8266 13 release release NN cord-015021-pol2qm74 8266 14 of of IN cord-015021-pol2qm74 8266 15 cytokines cytokine NNS cord-015021-pol2qm74 8266 16 , , , cord-015021-pol2qm74 8266 17 inflammatory inflammatory JJ cord-015021-pol2qm74 8266 18 mediators mediator NNS cord-015021-pol2qm74 8266 19 and and CC cord-015021-pol2qm74 8266 20 other other JJ cord-015021-pol2qm74 8266 21 substances substance NNS cord-015021-pol2qm74 8266 22 . . . cord-015021-pol2qm74 8267 1 These these DT cord-015021-pol2qm74 8267 2 parameters parameter NNS cord-015021-pol2qm74 8267 3 precisely precisely RB cord-015021-pol2qm74 8267 4 reflect reflect VBP cord-015021-pol2qm74 8267 5 the the DT cord-015021-pol2qm74 8267 6 degree degree NN cord-015021-pol2qm74 8267 7 of of IN cord-015021-pol2qm74 8267 8 the the DT cord-015021-pol2qm74 8267 9 generalized generalized JJ cord-015021-pol2qm74 8267 10 response response NN cord-015021-pol2qm74 8267 11 . . . cord-015021-pol2qm74 8268 1 Inflammation inflammation NN cord-015021-pol2qm74 8268 2 of of IN cord-015021-pol2qm74 8268 3 the the DT cord-015021-pol2qm74 8268 4 peritoneum peritoneum NN cord-015021-pol2qm74 8268 5 causes cause VBZ cord-015021-pol2qm74 8268 6 significant significant JJ cord-015021-pol2qm74 8268 7 morbidity morbidity NN cord-015021-pol2qm74 8268 8 . . . cord-015021-pol2qm74 8269 1 OBJEKTIVES OBJEKTIVES NNP cord-015021-pol2qm74 8269 2 : : : cord-015021-pol2qm74 8270 1 To to TO cord-015021-pol2qm74 8270 2 test test VB cord-015021-pol2qm74 8270 3 the the DT cord-015021-pol2qm74 8270 4 hypothesis hypothesis NN cord-015021-pol2qm74 8270 5 that that IN cord-015021-pol2qm74 8270 6 peritoneal peritoneal JJ cord-015021-pol2qm74 8270 7 mesothelial mesothelial JJ cord-015021-pol2qm74 8270 8 cells cell NNS cord-015021-pol2qm74 8270 9 play play VBP cord-015021-pol2qm74 8270 10 a a DT cord-015021-pol2qm74 8270 11 role role NN cord-015021-pol2qm74 8270 12 in in IN cord-015021-pol2qm74 8270 13 regulating regulate VBG cord-015021-pol2qm74 8270 14 inflammatory inflammatory JJ cord-015021-pol2qm74 8270 15 responses response NNS cord-015021-pol2qm74 8270 16 within within IN cord-015021-pol2qm74 8270 17 the the DT cord-015021-pol2qm74 8270 18 peritoneal peritoneal JJ cord-015021-pol2qm74 8270 19 cavity cavity NN cord-015021-pol2qm74 8270 20 , , , cord-015021-pol2qm74 8270 21 we -PRON- PRP cord-015021-pol2qm74 8270 22 examined examine VBD cord-015021-pol2qm74 8270 23 neutrophil neutrophil NN cord-015021-pol2qm74 8270 24 - - HYPH cord-015021-pol2qm74 8270 25 chemotactic chemotactic JJ cord-015021-pol2qm74 8270 26 activity activity NN cord-015021-pol2qm74 8270 27 ( ( -LRB- cord-015021-pol2qm74 8270 28 Interleukin Interleukin NNP cord-015021-pol2qm74 8270 29 8) 8) NN cord-015021-pol2qm74 8270 30 and and CC cord-015021-pol2qm74 8270 31 monocyte monocyte NNP cord-015021-pol2qm74 8270 32 - - HYPH cord-015021-pol2qm74 8270 33 chemotactic chemotactic JJ cord-015021-pol2qm74 8270 34 cytokine cytokine NN cord-015021-pol2qm74 8270 35 ( ( -LRB- cord-015021-pol2qm74 8270 36 MCP MCP NNP cord-015021-pol2qm74 8270 37 ) ) -RRB- cord-015021-pol2qm74 8270 38 release release NN cord-015021-pol2qm74 8270 39 by by IN cord-015021-pol2qm74 8270 40 sytokine sytokine NN cord-015021-pol2qm74 8270 41 - - HYPH cord-015021-pol2qm74 8270 42 etimulated etimulate VBN cord-015021-pol2qm74 8270 43 mesothelial mesothelial JJ cord-015021-pol2qm74 8270 44 cells cell NNS cord-015021-pol2qm74 8270 45 . . . cord-015021-pol2qm74 8271 1 Confluent Confluent NNP cord-015021-pol2qm74 8271 2 human human JJ cord-015021-pol2qm74 8271 3 peritoneal peritoneal NN cord-015021-pol2qm74 8271 4 mesothelial mesothelial JJ cord-015021-pol2qm74 8271 5 cells cell NNS cord-015021-pol2qm74 8271 6 were be VBD cord-015021-pol2qm74 8271 7 exposed expose VBN cord-015021-pol2qm74 8271 8 to to IN cord-015021-pol2qm74 8271 9 varying vary VBG cord-015021-pol2qm74 8271 10 concentrations concentration NNS cord-015021-pol2qm74 8271 11 of of IN cord-015021-pol2qm74 8271 12 phorbolmyristate phorbolmyristate JJ cord-015021-pol2qm74 8271 13 - - HYPH cord-015021-pol2qm74 8271 14 acetate acetate JJ cord-015021-pol2qm74 8271 15 ( ( -LRB- cord-015021-pol2qm74 8271 16 PMA PMA NNP cord-015021-pol2qm74 8271 17 ) ) -RRB- cord-015021-pol2qm74 8271 18 and and CC cord-015021-pol2qm74 8271 19 the the DT cord-015021-pol2qm74 8271 20 cytokines cytokine NNS cord-015021-pol2qm74 8271 21 tumorneerosis tumorneerosis NN cord-015021-pol2qm74 8271 22 factor factor NN cord-015021-pol2qm74 8271 23 a a DT cord-015021-pol2qm74 8271 24 ( ( -LRB- cord-015021-pol2qm74 8271 25 TNF TNF NNP cord-015021-pol2qm74 8271 26 a a DT cord-015021-pol2qm74 8271 27 ) ) -RRB- cord-015021-pol2qm74 8272 1 and and CC cord-015021-pol2qm74 8272 2 Interleukin Interleukin NNP cord-015021-pol2qm74 8272 3 i~ i~ XX cord-015021-pol2qm74 8273 1 ( ( -LRB- cord-015021-pol2qm74 8273 2 IL IL NNP cord-015021-pol2qm74 8273 3 - - HYPH cord-015021-pol2qm74 8273 4 I~ I~ NNP cord-015021-pol2qm74 8273 5 ) ) -RRB- cord-015021-pol2qm74 8273 6 . . . cord-015021-pol2qm74 8274 1 The the DT cord-015021-pol2qm74 8274 2 supernatant supernatant NN cord-015021-pol2qm74 8274 3 was be VBD cord-015021-pol2qm74 8274 4 examined examine VBN cord-015021-pol2qm74 8274 5 for for IN cord-015021-pol2qm74 8274 6 IL-8 IL-8 NNP cord-015021-pol2qm74 8274 7 by by IN cord-015021-pol2qm74 8274 8 ELISA ELISA NNP cord-015021-pol2qm74 8274 9 and and CC cord-015021-pol2qm74 8274 10 for for IN cord-015021-pol2qm74 8274 11 MCP MCP NNP cord-015021-pol2qm74 8274 12 by by IN cord-015021-pol2qm74 8274 13 investigating investigate VBG cord-015021-pol2qm74 8274 14 the the DT cord-015021-pol2qm74 8274 15 ehemotactic ehemotactic JJ cord-015021-pol2qm74 8274 16 activity activity NN cord-015021-pol2qm74 8274 17 for for IN cord-015021-pol2qm74 8274 18 isolated isolate VBN cord-015021-pol2qm74 8274 19 human human JJ cord-015021-pol2qm74 8274 20 monocytes monocyte NNS cord-015021-pol2qm74 8274 21 . . . cord-015021-pol2qm74 8275 1 Mesothelial mesothelial JJ cord-015021-pol2qm74 8275 2 cells cell NNS cord-015021-pol2qm74 8275 3 express express VBP cord-015021-pol2qm74 8275 4 low low JJ cord-015021-pol2qm74 8275 5 levels level NNS cord-015021-pol2qm74 8275 6 of of IN cord-015021-pol2qm74 8275 7 IL IL NNP cord-015021-pol2qm74 8275 8 8 8 CD cord-015021-pol2qm74 8275 9 and and CC cord-015021-pol2qm74 8275 10 monocyte monocyte NNP cord-015021-pol2qm74 8275 11 chemotactic chemotactic JJ cord-015021-pol2qm74 8275 12 activity activity NN cord-015021-pol2qm74 8275 13 when when WRB cord-015021-pol2qm74 8275 14 cultured culture VBN cord-015021-pol2qm74 8275 15 . . . cord-015021-pol2qm74 8276 1 These these DT cord-015021-pol2qm74 8276 2 activies activie NNS cord-015021-pol2qm74 8276 3 were be VBD cord-015021-pol2qm74 8276 4 significantly significantly RB cord-015021-pol2qm74 8276 5 increased increase VBN cord-015021-pol2qm74 8276 6 ( ( -LRB- cord-015021-pol2qm74 8276 7 2-fold 2-fold CD cord-015021-pol2qm74 8276 8 ) ) -RRB- cord-015021-pol2qm74 8276 9 after after IN cord-015021-pol2qm74 8276 10 stimulation stimulation NN cord-015021-pol2qm74 8276 11 with with IN cord-015021-pol2qm74 8276 12 either either CC cord-015021-pol2qm74 8276 13 TNF TNF NNP cord-015021-pol2qm74 8276 14 a a NNP cord-015021-pol2qm74 8276 15 or or CC cord-015021-pol2qm74 8276 16 IL IL NNP cord-015021-pol2qm74 8276 17 - - HYPH cord-015021-pol2qm74 8276 18 I~. I~. NNP cord-015021-pol2qm74 8277 1 Additionally additionally RB cord-015021-pol2qm74 8277 2 macrophage macrophage NN cord-015021-pol2qm74 8277 3 inflammatory inflammatory JJ cord-015021-pol2qm74 8277 4 protein protein NN cord-015021-pol2qm74 8277 5 was be VBD cord-015021-pol2qm74 8277 6 detected detect VBN cord-015021-pol2qm74 8277 7 . . . cord-015021-pol2qm74 8278 1 These these DT cord-015021-pol2qm74 8278 2 observations observation NNS cord-015021-pol2qm74 8278 3 provide provide VBP cord-015021-pol2qm74 8278 4 a a DT cord-015021-pol2qm74 8278 5 probably probably RB cord-015021-pol2qm74 8278 6 important important JJ cord-015021-pol2qm74 8278 7 mechanism mechanism NN cord-015021-pol2qm74 8278 8 whereby whereby WRB cord-015021-pol2qm74 8278 9 peritoneal peritoneal JJ cord-015021-pol2qm74 8278 10 mesothelial mesothelial JJ cord-015021-pol2qm74 8278 11 cells cell NNS cord-015021-pol2qm74 8278 12 respond respond VBP cord-015021-pol2qm74 8278 13 to to IN cord-015021-pol2qm74 8278 14 imflammatory imflammatory NN cord-015021-pol2qm74 8278 15 stimuli stimulus NNS cord-015021-pol2qm74 8278 16 released release VBN cord-015021-pol2qm74 8278 17 during during IN cord-015021-pol2qm74 8278 18 peritonitis peritonitis NN cord-015021-pol2qm74 8278 19 and and CC cord-015021-pol2qm74 8278 20 how how WRB cord-015021-pol2qm74 8278 21 leucocyte leucocyte JJ cord-015021-pol2qm74 8278 22 recruitment recruitment NN cord-015021-pol2qm74 8278 23 by by IN cord-015021-pol2qm74 8278 24 liberation liberation NN cord-015021-pol2qm74 8278 25 of of IN cord-015021-pol2qm74 8278 26 chemotactic chemotactic JJ cord-015021-pol2qm74 8278 27 cytokines cytokine NNS cord-015021-pol2qm74 8278 28 is be VBZ cord-015021-pol2qm74 8278 29 regulated regulate VBN cord-015021-pol2qm74 8278 30 . . . cord-015021-pol2qm74 8279 1 The the DT cord-015021-pol2qm74 8279 2 perioperative perioperative JJ cord-015021-pol2qm74 8279 3 course course NN cord-015021-pol2qm74 8279 4 of of IN cord-015021-pol2qm74 8279 5 LPS LPS NNP cord-015021-pol2qm74 8279 6 , , , cord-015021-pol2qm74 8279 7 TNFa TNFa NNS cord-015021-pol2qm74 8279 8 and and CC cord-015021-pol2qm74 8280 1 IL-6 IL-6 NNP cord-015021-pol2qm74 8280 2 in in IN cord-015021-pol2qm74 8280 3 19 19 CD cord-015021-pol2qm74 8280 4 patients patient NNS cord-015021-pol2qm74 8280 5 with with IN cord-015021-pol2qm74 8280 6 bacteriologic bacteriologic NNP cord-015021-pol2qm74 8280 7 proven prove VBN cord-015021-pol2qm74 8280 8 abdominal abdominal JJ cord-015021-pol2qm74 8280 9 infection infection NN cord-015021-pol2qm74 8280 10 ( ( -LRB- cord-015021-pol2qm74 8280 11 intraabdominal intraabdominal JJ cord-015021-pol2qm74 8280 12 abscess abscess NN cord-015021-pol2qm74 8280 13 10 10 CD cord-015021-pol2qm74 8280 14 , , , cord-015021-pol2qm74 8280 15 diffuse diffuse VB cord-015021-pol2qm74 8280 16 peritonitis peritonitis NN cord-015021-pol2qm74 8280 17 4 4 CD cord-015021-pol2qm74 8280 18 , , , cord-015021-pol2qm74 8280 19 pancreatic pancreatic JJ cord-015021-pol2qm74 8280 20 necrosis necrosis NN cord-015021-pol2qm74 8280 21 2 2 CD cord-015021-pol2qm74 8280 22 , , , cord-015021-pol2qm74 8280 23 pancreatic pancreatic JJ cord-015021-pol2qm74 8280 24 abscess abscess NN cord-015021-pol2qm74 8280 25 3 3 CD cord-015021-pol2qm74 8280 26 ) ) -RRB- cord-015021-pol2qm74 8280 27 was be VBD cord-015021-pol2qm74 8280 28 followed follow VBN cord-015021-pol2qm74 8280 29 prospectively prospectively RB cord-015021-pol2qm74 8280 30 and and CC cord-015021-pol2qm74 8280 31 evaluated evaluate VBN cord-015021-pol2qm74 8280 32 for for IN cord-015021-pol2qm74 8280 33 possible possible JJ cord-015021-pol2qm74 8280 34 correlation correlation NN cord-015021-pol2qm74 8280 35 with with IN cord-015021-pol2qm74 8280 36 septic septic JJ cord-015021-pol2qm74 8280 37 state state NN cord-015021-pol2qm74 8280 38 and and CC cord-015021-pol2qm74 8280 39 organ organ NN cord-015021-pol2qm74 8280 40 function function NN cord-015021-pol2qm74 8280 41 . . . cord-015021-pol2qm74 8281 1 Methods method NNS cord-015021-pol2qm74 8281 2 : : : cord-015021-pol2qm74 8281 3 Patients patient NNS cord-015021-pol2qm74 8281 4 were be VBD cord-015021-pol2qm74 8281 5 studied study VBN cord-015021-pol2qm74 8281 6 in in IN cord-015021-pol2qm74 8281 7 a a DT cord-015021-pol2qm74 8281 8 6 6 CD cord-015021-pol2qm74 8281 9 to to TO cord-015021-pol2qm74 8281 10 10 10 CD cord-015021-pol2qm74 8281 11 hours hour NNS cord-015021-pol2qm74 8281 12 period period NN cord-015021-pol2qm74 8281 13 during during IN cord-015021-pol2qm74 8281 14 their -PRON- PRP$ cord-015021-pol2qm74 8281 15 first first JJ cord-015021-pol2qm74 8281 16 surgical surgical JJ cord-015021-pol2qm74 8281 17 intervention intervention NN cord-015021-pol2qm74 8281 18 because because IN cord-015021-pol2qm74 8281 19 of of IN cord-015021-pol2qm74 8281 20 intraabdominal intraabdominal JJ cord-015021-pol2qm74 8281 21 infection infection NN cord-015021-pol2qm74 8281 22 . . . cord-015021-pol2qm74 8282 1 All all DT cord-015021-pol2qm74 8282 2 were be VBD cord-015021-pol2qm74 8282 3 monitored monitor VBN cord-015021-pol2qm74 8282 4 for for IN cord-015021-pol2qm74 8282 5 their -PRON- PRP$ cord-015021-pol2qm74 8282 6 cardiovascular cardiovascular JJ cord-015021-pol2qm74 8282 7 , , , cord-015021-pol2qm74 8282 8 respiratory respiratory JJ cord-015021-pol2qm74 8282 9 , , , cord-015021-pol2qm74 8282 10 hepatic hepatic JJ cord-015021-pol2qm74 8282 11 and and CC cord-015021-pol2qm74 8282 12 renal renal JJ cord-015021-pol2qm74 8282 13 function function NN cord-015021-pol2qm74 8282 14 . . . cord-015021-pol2qm74 8283 1 Plasma plasma NN cord-015021-pol2qm74 8283 2 samples sample NNS cord-015021-pol2qm74 8283 3 for for IN cord-015021-pol2qm74 8283 4 LPS lp NNS cord-015021-pol2qm74 8283 5 . . . cord-015021-pol2qm74 8284 1 TNFa TNFa NNP cord-015021-pol2qm74 8284 2 and and CC cord-015021-pol2qm74 8284 3 IL-6 IL-6 NNP cord-015021-pol2qm74 8284 4 determination determination NN cord-015021-pol2qm74 8284 5 were be VBD cord-015021-pol2qm74 8284 6 drawn draw VBN cord-015021-pol2qm74 8284 7 preoperatively preoperatively RB cord-015021-pol2qm74 8284 8 , , , cord-015021-pol2qm74 8284 9 intraoperatively intraoperatively RB cord-015021-pol2qm74 8284 10 , , , cord-015021-pol2qm74 8284 11 and and CC cord-015021-pol2qm74 8284 12 until until IN cord-015021-pol2qm74 8284 13 2h 2h CD cord-015021-pol2qm74 8284 14 postoperatively postoperatively RB cord-015021-pol2qm74 8284 15 in in IN cord-015021-pol2qm74 8284 16 regular regular JJ cord-015021-pol2qm74 8284 17 intervals interval NNS cord-015021-pol2qm74 8284 18 ( ( -LRB- cord-015021-pol2qm74 8284 19 min min NNP cord-015021-pol2qm74 8284 20 7 7 CD cord-015021-pol2qm74 8284 21 / / SYM cord-015021-pol2qm74 8284 22 pat pat NNP cord-015021-pol2qm74 8284 23 ) ) -RRB- cord-015021-pol2qm74 8285 1 , , , cord-015021-pol2qm74 8285 2 Results result NNS cord-015021-pol2qm74 8285 3 : : : cord-015021-pol2qm74 8286 1 Preoperative Preoperative NNP cord-015021-pol2qm74 8286 2 APACHE APACHE NNP cord-015021-pol2qm74 8286 3 II II NNP cord-015021-pol2qm74 8286 4 was be VBD cord-015021-pol2qm74 8286 5 12 12 CD cord-015021-pol2qm74 8286 6 in in IN cord-015021-pol2qm74 8286 7 median median NN cord-015021-pol2qm74 8286 8 ( ( -LRB- cord-015021-pol2qm74 8286 9 rain rain NN cord-015021-pol2qm74 8286 10 4 4 CD cord-015021-pol2qm74 8286 11 , , , cord-015021-pol2qm74 8286 12 max max NNP cord-015021-pol2qm74 8286 13 25 25 CD cord-015021-pol2qm74 8286 14 ) ) -RRB- cord-015021-pol2qm74 8286 15 . . . cord-015021-pol2qm74 8287 1 10 10 CD cord-015021-pol2qm74 8287 2 patients patient NNS cord-015021-pol2qm74 8287 3 fulfilled fulfil VBD cord-015021-pol2qm74 8287 4 the the DT cord-015021-pol2qm74 8287 5 criteria criterion NNS cord-015021-pol2qm74 8287 6 of of IN cord-015021-pol2qm74 8287 7 SIRS SIRS NNP cord-015021-pol2qm74 8287 8 . . . cord-015021-pol2qm74 8288 1 4 4 CD cord-015021-pol2qm74 8288 2 of of IN cord-015021-pol2qm74 8288 3 them -PRON- PRP cord-015021-pol2qm74 8288 4 were be VBD cord-015021-pol2qm74 8288 5 in in IN cord-015021-pol2qm74 8288 6 septic septic JJ cord-015021-pol2qm74 8288 7 shock shock NN cord-015021-pol2qm74 8288 8 . . . cord-015021-pol2qm74 8289 1 There there EX cord-015021-pol2qm74 8289 2 was be VBD cord-015021-pol2qm74 8289 3 a a DT cord-015021-pol2qm74 8289 4 significant significant JJ cord-015021-pol2qm74 8289 5 correlation correlation NN cord-015021-pol2qm74 8289 6 between between IN cord-015021-pol2qm74 8289 7 preoperative preoperative JJ cord-015021-pol2qm74 8289 8 TNFa TNFa NNS cord-015021-pol2qm74 8289 9 and and CC cord-015021-pol2qm74 8289 10 APACHE APACHE NNP cord-015021-pol2qm74 8289 11 II II NNP cord-015021-pol2qm74 8290 1 ( ( -LRB- cord-015021-pol2qm74 8290 2 p=0,000 p=0,000 NNP cord-015021-pol2qm74 8291 1 I -PRON- PRP cord-015021-pol2qm74 8291 2 , , , cord-015021-pol2qm74 8291 3 Spearman Spearman NNP cord-015021-pol2qm74 8291 4 coefficient coefficient NN cord-015021-pol2qm74 8291 5 ) ) -RRB- cord-015021-pol2qm74 8291 6 . . . cord-015021-pol2qm74 8292 1 Preoperative Preoperative NNP cord-015021-pol2qm74 8292 2 cardiovascular cardiovascular NN cord-015021-pol2qm74 8292 3 ( ( -LRB- cord-015021-pol2qm74 8292 4 systol systol NNP cord-015021-pol2qm74 8292 5 . . . cord-015021-pol2qm74 8293 1 RR<90 RR<90 NNP cord-015021-pol2qm74 8293 2 mmHg mmHg NNP cord-015021-pol2qm74 8293 3 ) ) -RRB- cord-015021-pol2qm74 8293 4 and and CC cord-015021-pol2qm74 8293 5 respiratory respiratory JJ cord-015021-pol2qm74 8293 6 ( ( -LRB- cord-015021-pol2qm74 8293 7 PaO2<75 PaO2<75 NNP cord-015021-pol2qm74 8293 8 mm mm CD cord-015021-pol2qm74 8293 9 Hg Hg NNP cord-015021-pol2qm74 8293 10 ) ) -RRB- cord-015021-pol2qm74 8293 11 dysfunction dysfunction NN cord-015021-pol2qm74 8293 12 were be VBD cord-015021-pol2qm74 8293 13 associated associate VBN cord-015021-pol2qm74 8293 14 with with IN cord-015021-pol2qm74 8293 15 significantly significantly RB cord-015021-pol2qm74 8293 16 elevated elevated JJ cord-015021-pol2qm74 8293 17 TNFa TNFa NNS cord-015021-pol2qm74 8293 18 ( ( -LRB- cord-015021-pol2qm74 8293 19 cardial cardial NNP cord-015021-pol2qm74 8293 20 : : : cord-015021-pol2qm74 8293 21 p=0,000 p=0,000 . cord-015021-pol2qm74 8294 1 I -PRON- PRP cord-015021-pol2qm74 8294 2 , , , cord-015021-pol2qm74 8294 3 Wilcoxon Wilcoxon NNP cord-015021-pol2qm74 8294 4 ; ; : cord-015021-pol2qm74 8294 5 pulmonal pulmonal JJ cord-015021-pol2qm74 8294 6 : : : cord-015021-pol2qm74 8294 7 p=0,0003 p=0,0003 NNP cord-015021-pol2qm74 8294 8 ) ) -RRB- cord-015021-pol2qm74 8294 9 and and CC cord-015021-pol2qm74 8295 1 IL-6 IL-6 NNP cord-015021-pol2qm74 8295 2 ( ( -LRB- cord-015021-pol2qm74 8295 3 Cardial Cardial NNP cord-015021-pol2qm74 8295 4 : : : cord-015021-pol2qm74 8295 5 p=0,2 p=0,2 JJ cord-015021-pol2qm74 8295 6 ; ; : cord-015021-pol2qm74 8295 7 pulmonal pulmonal JJ cord-015021-pol2qm74 8295 8 : : : cord-015021-pol2qm74 8295 9 p=0.0001 p=0.0001 NNS cord-015021-pol2qm74 8295 10 ) ) -RRB- cord-015021-pol2qm74 8296 1 Overall overall RB cord-015021-pol2qm74 8296 2 , , , cord-015021-pol2qm74 8296 3 LPS LPS NNP cord-015021-pol2qm74 8296 4 , , , cord-015021-pol2qm74 8296 5 TNFa TNFa NNS cord-015021-pol2qm74 8296 6 and and CC cord-015021-pol2qm74 8296 7 IL-6 IL-6 NNP cord-015021-pol2qm74 8296 8 values value NNS cord-015021-pol2qm74 8296 9 varied vary VBN cord-015021-pol2qm74 8296 10 considerably considerably RB cord-015021-pol2qm74 8296 11 during during IN cord-015021-pol2qm74 8296 12 the the DT cord-015021-pol2qm74 8296 13 observation observation NN cord-015021-pol2qm74 8296 14 period period NN cord-015021-pol2qm74 8296 15 . . . cord-015021-pol2qm74 8297 1 However however RB cord-015021-pol2qm74 8297 2 , , , cord-015021-pol2qm74 8297 3 TNFa TNFa NNP cord-015021-pol2qm74 8297 4 was be VBD cord-015021-pol2qm74 8297 5 markedly markedly RB cord-015021-pol2qm74 8297 6 higher high JJR cord-015021-pol2qm74 8297 7 in in IN cord-015021-pol2qm74 8297 8 patients patient NNS cord-015021-pol2qm74 8297 9 with with IN cord-015021-pol2qm74 8297 10 SIRS SIRS NNP cord-015021-pol2qm74 8297 11 and and CC cord-015021-pol2qm74 8297 12 septic septic JJ cord-015021-pol2qm74 8297 13 shock shock NN cord-015021-pol2qm74 8297 14 ( ( -LRB- cord-015021-pol2qm74 8297 15 group group NN cord-015021-pol2qm74 8297 16 A a NN cord-015021-pol2qm74 8297 17 : : : cord-015021-pol2qm74 8298 1 n= n= NNP cord-015021-pol2qm74 8298 2 I I NNP cord-015021-pol2qm74 8298 3 0 0 CD cord-015021-pol2qm74 8298 4 , , , cord-015021-pol2qm74 8299 1 mean mean VB cord-015021-pol2qm74 8299 2 182 182 CD cord-015021-pol2qm74 8299 3 pg pg NN cord-015021-pol2qm74 8299 4 / / SYM cord-015021-pol2qm74 8299 5 ml ml NN cord-015021-pol2qm74 8299 6 ) ) -RRB- cord-015021-pol2qm74 8300 1 than than IN cord-015021-pol2qm74 8300 2 in in IN cord-015021-pol2qm74 8300 3 those those DT cord-015021-pol2qm74 8300 4 who who WP cord-015021-pol2qm74 8300 5 did do VBD cord-015021-pol2qm74 8300 6 not not RB cord-015021-pol2qm74 8300 7 fulfill fulfill VB cord-015021-pol2qm74 8300 8 these these DT cord-015021-pol2qm74 8300 9 criteria criterion NNS cord-015021-pol2qm74 8300 10 ( ( -LRB- cord-015021-pol2qm74 8300 11 group group NN cord-015021-pol2qm74 8300 12 B B NNP cord-015021-pol2qm74 8300 13 ; ; : cord-015021-pol2qm74 8300 14 n=9 n=9 NN cord-015021-pol2qm74 8300 15 , , , cord-015021-pol2qm74 8300 16 mean mean VB cord-015021-pol2qm74 8300 17 24 24 CD cord-015021-pol2qm74 8300 18 pg pg NN cord-015021-pol2qm74 8300 19 / / SYM cord-015021-pol2qm74 8300 20 ml ml NN cord-015021-pol2qm74 8300 21 ; ; : cord-015021-pol2qm74 8301 1 p=0,00 p=0,00 NNP cord-015021-pol2qm74 8302 1 I -PRON- PRP cord-015021-pol2qm74 8302 2 , , , cord-015021-pol2qm74 8302 3 Wilcoxon Wilcoxon NNP cord-015021-pol2qm74 8302 4 ) ) -RRB- cord-015021-pol2qm74 8302 5 . . . cord-015021-pol2qm74 8303 1 IL-6 IL-6 NNP cord-015021-pol2qm74 8303 2 was be VBD cord-015021-pol2qm74 8303 3 significantly significantly RB cord-015021-pol2qm74 8303 4 higher high JJR cord-015021-pol2qm74 8303 5 in in IN cord-015021-pol2qm74 8303 6 group group NN cord-015021-pol2qm74 8303 7 A A NNP cord-015021-pol2qm74 8303 8 ( ( -LRB- cord-015021-pol2qm74 8303 9 mean mean JJ cord-015021-pol2qm74 8303 10 2169 2169 CD cord-015021-pol2qm74 8303 11 pg pg NN cord-015021-pol2qm74 8303 12 / / SYM cord-015021-pol2qm74 8303 13 ml ml NNP cord-015021-pol2qm74 8303 14 ) ) -RRB- cord-015021-pol2qm74 8303 15 than than IN cord-015021-pol2qm74 8303 16 in in IN cord-015021-pol2qm74 8303 17 group group NN cord-015021-pol2qm74 8303 18 B B NNP cord-015021-pol2qm74 8303 19 ( ( -LRB- cord-015021-pol2qm74 8303 20 mean mean VB cord-015021-pol2qm74 8303 21 191 191 CD cord-015021-pol2qm74 8303 22 pg pg NN cord-015021-pol2qm74 8303 23 / / SYM cord-015021-pol2qm74 8303 24 ml ml NN cord-015021-pol2qm74 8303 25 ; ; : cord-015021-pol2qm74 8304 1 p=0,0O p=0,0O NNP cord-015021-pol2qm74 8304 2 I I NNP cord-015021-pol2qm74 8304 3 Wilcoxon Wilcoxon NNP cord-015021-pol2qm74 8304 4 ) ) -RRB- cord-015021-pol2qm74 8304 5 . . . cord-015021-pol2qm74 8305 1 Conclusion conclusion NN cord-015021-pol2qm74 8305 2 : : : cord-015021-pol2qm74 8306 1 Perioperative Perioperative NNP cord-015021-pol2qm74 8306 2 TNFa TNFa NNP cord-015021-pol2qm74 8306 3 and and CC cord-015021-pol2qm74 8306 4 IL-6 IL-6 NNP cord-015021-pol2qm74 8306 5 were be VBD cord-015021-pol2qm74 8306 6 shown show VBN cord-015021-pol2qm74 8306 7 to to TO cord-015021-pol2qm74 8306 8 correlate correlate VB cord-015021-pol2qm74 8306 9 significantly significantly RB cord-015021-pol2qm74 8306 10 with with IN cord-015021-pol2qm74 8306 11 preoperative preoperative JJ cord-015021-pol2qm74 8306 12 organ organ NN cord-015021-pol2qm74 8306 13 function function NN cord-015021-pol2qm74 8306 14 , , , cord-015021-pol2qm74 8306 15 APACHE APACHE NNP cord-015021-pol2qm74 8306 16 II II NNP cord-015021-pol2qm74 8306 17 and and CC cord-015021-pol2qm74 8306 18 the the DT cord-015021-pol2qm74 8306 19 severity severity NN cord-015021-pol2qm74 8306 20 of of IN cord-015021-pol2qm74 8306 21 sepsis sepsis NN cord-015021-pol2qm74 8306 22 . . . cord-015021-pol2qm74 8307 1 These these DT cord-015021-pol2qm74 8307 2 results result NNS cord-015021-pol2qm74 8307 3 could could MD cord-015021-pol2qm74 8307 4 help help VB cord-015021-pol2qm74 8307 5 to to TO cord-015021-pol2qm74 8307 6 define define VB cord-015021-pol2qm74 8307 7 patients patient NNS cord-015021-pol2qm74 8307 8 that that WDT cord-015021-pol2qm74 8307 9 might may MD cord-015021-pol2qm74 8307 10 benefit benefit VB cord-015021-pol2qm74 8307 11 from from IN cord-015021-pol2qm74 8307 12 further further JJ cord-015021-pol2qm74 8307 13 therapeutic therapeutic JJ cord-015021-pol2qm74 8307 14 strategies strategy NNS cord-015021-pol2qm74 8307 15 , , , cord-015021-pol2qm74 8307 16 e.g. e.g. DT cord-015021-pol2qm74 8307 17 antibody antibody NN cord-015021-pol2qm74 8307 18 administration administration NN cord-015021-pol2qm74 8307 19 . . . cord-015021-pol2qm74 8308 1 Department Department NNP cord-015021-pol2qm74 8308 2 of of IN cord-015021-pol2qm74 8308 3 Surgery Surgery NNP cord-015021-pol2qm74 8308 4 , , , cord-015021-pol2qm74 8308 5 University University NNP cord-015021-pol2qm74 8308 6 Vienna Vienna NNP cord-015021-pol2qm74 8308 7 , , , cord-015021-pol2qm74 8308 8 AKH AKH NNP cord-015021-pol2qm74 8308 9 Wien Wien NNP cord-015021-pol2qm74 8308 10 , , , cord-015021-pol2qm74 8308 11 Wahringer Wahringer NNP cord-015021-pol2qm74 8308 12 Gurtel Gurtel NNP cord-015021-pol2qm74 8308 13 18 18 CD cord-015021-pol2qm74 8308 14 - - SYM cord-015021-pol2qm74 8308 15 20 20 CD cord-015021-pol2qm74 8308 16 , , , cord-015021-pol2qm74 8308 17 1090 1090 CD cord-015021-pol2qm74 8308 18 Wien Wien NNP cord-015021-pol2qm74 8308 19 . . . cord-015021-pol2qm74 8309 1 Aim Aim NNP cord-015021-pol2qm74 8309 2 of of IN cord-015021-pol2qm74 8309 3 the the DT cord-015021-pol2qm74 8309 4 study study NN cord-015021-pol2qm74 8309 5 : : : cord-015021-pol2qm74 8309 6 The the DT cord-015021-pol2qm74 8309 7 purpose purpose NN cord-015021-pol2qm74 8309 8 of of IN cord-015021-pol2qm74 8309 9 this this DT cord-015021-pol2qm74 8309 10 pilot pilot NN cord-015021-pol2qm74 8309 11 study study NN cord-015021-pol2qm74 8309 12 was be VBD cord-015021-pol2qm74 8309 13 to to TO cord-015021-pol2qm74 8309 14 establish establish VB cord-015021-pol2qm74 8309 15 and and CC cord-015021-pol2qm74 8309 16 to to TO cord-015021-pol2qm74 8309 17 prove prove VB cord-015021-pol2qm74 8309 18 a a DT cord-015021-pol2qm74 8309 19 standardized standardized JJ cord-015021-pol2qm74 8309 20 reproducible reproducible JJ cord-015021-pol2qm74 8309 21 animal animal NN cord-015021-pol2qm74 8309 22 model model NN cord-015021-pol2qm74 8309 23 of of IN cord-015021-pol2qm74 8309 24 intraperitoneal intraperitoneal JJ cord-015021-pol2qm74 8309 25 sepsis sepsis NN cord-015021-pol2qm74 8309 26 induced induce VBN cord-015021-pol2qm74 8309 27 by by IN cord-015021-pol2qm74 8309 28 E.coli e.coli NN cord-015021-pol2qm74 8309 29 - - HYPH cord-015021-pol2qm74 8309 30 endotoxinaemia endotoxinaemia NN cord-015021-pol2qm74 8309 31 in in IN cord-015021-pol2qm74 8309 32 LEW.lW lew.lw NN cord-015021-pol2qm74 8309 33 - - HYPH cord-015021-pol2qm74 8309 34 rats rat NNS cord-015021-pol2qm74 8309 35 in in IN cord-015021-pol2qm74 8309 36 order order NN cord-015021-pol2qm74 8309 37 to to TO cord-015021-pol2qm74 8309 38 investigate investigate VB cord-015021-pol2qm74 8309 39 early early JJ cord-015021-pol2qm74 8309 40 immunoserological immunoserological JJ cord-015021-pol2qm74 8309 41 responses response NNS cord-015021-pol2qm74 8309 42 to to TO cord-015021-pol2qm74 8309 43 find find VB cord-015021-pol2qm74 8309 44 a a DT cord-015021-pol2qm74 8309 45 mediator mediator NN cord-015021-pol2qm74 8309 46 based base VBN cord-015021-pol2qm74 8309 47 evaluating evaluate VBG cord-015021-pol2qm74 8309 48 system system NN cord-015021-pol2qm74 8309 49 of of IN cord-015021-pol2qm74 8309 50 peritonitis peritonitis NN cord-015021-pol2qm74 8309 51 sepsis sepsis NN cord-015021-pol2qm74 8309 52 . . . cord-015021-pol2qm74 8310 1 Materials material NNS cord-015021-pol2qm74 8310 2 and and CC cord-015021-pol2qm74 8310 3 methods method NNS cord-015021-pol2qm74 8310 4 : : : cord-015021-pol2qm74 8310 5 In in IN cord-015021-pol2qm74 8310 6 30 30 CD cord-015021-pol2qm74 8310 7 LEW LEW NNP cord-015021-pol2qm74 8310 8 . . . cord-015021-pol2qm74 8311 1 lW lw LS cord-015021-pol2qm74 8311 2 - - HYPH cord-015021-pol2qm74 8311 3 rats rat NNS cord-015021-pol2qm74 8311 4 , , , cord-015021-pol2qm74 8311 5 diffuse diffuse JJ cord-015021-pol2qm74 8311 6 peritonitis peritonitis NN cord-015021-pol2qm74 8311 7 was be VBD cord-015021-pol2qm74 8311 8 induced induce VBN cord-015021-pol2qm74 8311 9 by by IN cord-015021-pol2qm74 8311 10 intraperitoneal intraperitoneal JJ cord-015021-pol2qm74 8311 11 injection injection NN cord-015021-pol2qm74 8311 12 of of IN cord-015021-pol2qm74 8311 13 a a DT cord-015021-pol2qm74 8311 14 mixture mixture NN cord-015021-pol2qm74 8311 15 of of IN cord-015021-pol2qm74 8311 16 E.coli E.coli NNS cord-015021-pol2qm74 8311 17 ( ( -LRB- cord-015021-pol2qm74 8311 18 KhU KhU NNP cord-015021-pol2qm74 8311 19 + + SYM cord-015021-pol2qm74 8311 20 ) ) -RRB- cord-015021-pol2qm74 8311 21 and and CC cord-015021-pol2qm74 8311 22 autogenous autogenous JJ cord-015021-pol2qm74 8311 23 haemoglobin haemoglobin NN cord-015021-pol2qm74 8311 24 solution solution NN cord-015021-pol2qm74 8311 25 . . . cord-015021-pol2qm74 8312 1 In in IN cord-015021-pol2qm74 8312 2 the the DT cord-015021-pol2qm74 8312 3 control control NN cord-015021-pol2qm74 8312 4 animal animal NN cord-015021-pol2qm74 8312 5 group group NN cord-015021-pol2qm74 8312 6 ( ( -LRB- cord-015021-pol2qm74 8312 7 n= n= NNP cord-015021-pol2qm74 8312 8 12 12 CD cord-015021-pol2qm74 8312 9 ) ) -RRB- cord-015021-pol2qm74 8312 10 an an DT cord-015021-pol2qm74 8312 11 intraperitoneally intraperitoneally NN cord-015021-pol2qm74 8312 12 injection injection NN cord-015021-pol2qm74 8312 13 of of IN cord-015021-pol2qm74 8312 14 physiological physiological JJ cord-015021-pol2qm74 8312 15 saline saline NN cord-015021-pol2qm74 8312 16 solution solution NN cord-015021-pol2qm74 8312 17 was be VBD cord-015021-pol2qm74 8312 18 done do VBN cord-015021-pol2qm74 8312 19 . . . cord-015021-pol2qm74 8313 1 Blood blood NN cord-015021-pol2qm74 8313 2 samples sample NNS cord-015021-pol2qm74 8313 3 were be VBD cord-015021-pol2qm74 8313 4 obtained obtain VBN cord-015021-pol2qm74 8313 5 by by IN cord-015021-pol2qm74 8313 6 heart heart NN cord-015021-pol2qm74 8313 7 puncture puncture NN cord-015021-pol2qm74 8313 8 after after IN cord-015021-pol2qm74 8313 9 6 6 CD cord-015021-pol2qm74 8313 10 hours hour NNS cord-015021-pol2qm74 8313 11 . . . cord-015021-pol2qm74 8314 1 Stastistieal stastistieal JJ cord-015021-pol2qm74 8314 2 calculations calculation NNS cord-015021-pol2qm74 8314 3 were be VBD cord-015021-pol2qm74 8314 4 performed perform VBN cord-015021-pol2qm74 8314 5 on on IN cord-015021-pol2qm74 8314 6 a a DT cord-015021-pol2qm74 8314 7 personal personal JJ cord-015021-pol2qm74 8314 8 computer computer NN cord-015021-pol2qm74 8314 9 with with IN cord-015021-pol2qm74 8314 10 the the DT cord-015021-pol2qm74 8314 11 SPSS SPSS NNP cord-015021-pol2qm74 8314 12 programm programm NNP cord-015021-pol2qm74 8314 13 Vers Vers NNP cord-015021-pol2qm74 8314 14 . . . cord-015021-pol2qm74 8315 1 4.01 4.01 CD cord-015021-pol2qm74 8316 1 ( ( -LRB- cord-015021-pol2qm74 8316 2 correlation correlation NN cord-015021-pol2qm74 8316 3 with with IN cord-015021-pol2qm74 8316 4 Pearson Pearson NNP cord-015021-pol2qm74 8316 5 's 's POS cord-015021-pol2qm74 8316 6 R r NN cord-015021-pol2qm74 8316 7 , , , cord-015021-pol2qm74 8316 8 Mann Mann NNP cord-015021-pol2qm74 8316 9 - - HYPH cord-015021-pol2qm74 8316 10 Whitney Whitney NNP cord-015021-pol2qm74 8316 11 - - HYPH cord-015021-pol2qm74 8316 12 U U NNP cord-015021-pol2qm74 8316 13 - - HYPH cord-015021-pol2qm74 8316 14 Test test NN cord-015021-pol2qm74 8316 15 , , , cord-015021-pol2qm74 8316 16 descriptives descriptive NNS cord-015021-pol2qm74 8316 17 statistics statistic NNS cord-015021-pol2qm74 8316 18 , , , cord-015021-pol2qm74 8316 19 discriminant discriminant NN cord-015021-pol2qm74 8316 20 analysis analysis NN cord-015021-pol2qm74 8316 21 ) ) -RRB- cord-015021-pol2qm74 8316 22 . . . cord-015021-pol2qm74 8317 1 Results result NNS cord-015021-pol2qm74 8317 2 : : : cord-015021-pol2qm74 8318 1 In in IN cord-015021-pol2qm74 8318 2 contrast contrast NN cord-015021-pol2qm74 8318 3 to to IN cord-015021-pol2qm74 8318 4 the the DT cord-015021-pol2qm74 8318 5 sham sham NN cord-015021-pol2qm74 8318 6 treated treat VBN cord-015021-pol2qm74 8318 7 rats rat NNS cord-015021-pol2qm74 8318 8 , , , cord-015021-pol2qm74 8318 9 the the DT cord-015021-pol2qm74 8318 10 peritonitis peritonitis NN cord-015021-pol2qm74 8318 11 animals animal NNS cord-015021-pol2qm74 8318 12 showed show VBD cord-015021-pol2qm74 8318 13 significant significant JJ cord-015021-pol2qm74 8318 14 differences difference NNS cord-015021-pol2qm74 8318 15 in in IN cord-015021-pol2qm74 8318 16 the the DT cord-015021-pol2qm74 8318 17 concentrations concentration NNS cord-015021-pol2qm74 8318 18 of of IN cord-015021-pol2qm74 8318 19 endotoxin endotoxin NN cord-015021-pol2qm74 8318 20 , , , cord-015021-pol2qm74 8318 21 interferon interferon NN cord-015021-pol2qm74 8318 22 - - HYPH cord-015021-pol2qm74 8318 23 gamma gamma NN cord-015021-pol2qm74 8318 24 ( ( -LRB- cord-015021-pol2qm74 8318 25 WN WN NNP cord-015021-pol2qm74 8318 26 - - HYPH cord-015021-pol2qm74 8318 27 y y NNP cord-015021-pol2qm74 8318 28 ) ) -RRB- cord-015021-pol2qm74 8318 29 , , , cord-015021-pol2qm74 8318 30 the the DT cord-015021-pol2qm74 8318 31 pteridin pteridin NNP cord-015021-pol2qm74 8318 32 derivate derivate NNP cord-015021-pol2qm74 8318 33 biopterin biopterin NNP cord-015021-pol2qm74 8318 34 and and CC cord-015021-pol2qm74 8318 35 serum serum NN cord-015021-pol2qm74 8318 36 PLA2-activities pla2-activitie NNS cord-015021-pol2qm74 8319 1 [ [ -LRB- cord-015021-pol2qm74 8319 2 endotoxin endotoxin NN cord-015021-pol2qm74 8319 3 range range NN cord-015021-pol2qm74 8319 4 from from IN cord-015021-pol2qm74 8319 5 0.064 0.064 CD cord-015021-pol2qm74 8319 6 EU EU NNP cord-015021-pol2qm74 8319 7 / / SYM cord-015021-pol2qm74 8319 8 I i NN cord-015021-pol2qm74 8319 9 , , , cord-015021-pol2qm74 8319 10 SD=0.19 SD=0.19 VBZ cord-015021-pol2qm74 8319 11 to to IN cord-015021-pol2qm74 8319 12 102.38 102.38 CD cord-015021-pol2qm74 8319 13 EU/1 EU/1 NNP cord-015021-pol2qm74 8319 14 , , , cord-015021-pol2qm74 8320 1 SD-145.4 SD-145.4 NNP cord-015021-pol2qm74 8321 1 ( ( -LRB- cord-015021-pol2qm74 8321 2 p p NN cord-015021-pol2qm74 8321 3 < < XX cord-015021-pol2qm74 8321 4 0 0 CD cord-015021-pol2qm74 8321 5 0001 0001 CD cord-015021-pol2qm74 8321 6 ) ) -RRB- cord-015021-pol2qm74 8321 7 , , , cord-015021-pol2qm74 8321 8 IFN-¥ ifn-¥ CD cord-015021-pol2qm74 8321 9 levels level NNS cord-015021-pol2qm74 8321 10 , , , cord-015021-pol2qm74 8321 11 range range VBP cord-015021-pol2qm74 8321 12 from from IN cord-015021-pol2qm74 8321 13 147.9 147.9 CD cord-015021-pol2qm74 8321 14 pg pg NN cord-015021-pol2qm74 8321 15 / / SYM cord-015021-pol2qm74 8321 16 ml ml NNS cord-015021-pol2qm74 8321 17 , , , cord-015021-pol2qm74 8321 18 SD-141.6 SD-141.6 NNPS cord-015021-pol2qm74 8321 19 , , , cord-015021-pol2qm74 8321 20 to to IN cord-015021-pol2qm74 8321 21 4591 4591 CD cord-015021-pol2qm74 8321 22 pg pg NNP cord-015021-pol2qm74 8321 23 / / SYM cord-015021-pol2qm74 8321 24 ml ml NNP cord-015021-pol2qm74 8321 25 , , , cord-015021-pol2qm74 8321 26 SD=6541 SD=6541 NNP cord-015021-pol2qm74 8322 1 ( ( -LRB- cord-015021-pol2qm74 8322 2 p p NN cord-015021-pol2qm74 8322 3 < < XX cord-015021-pol2qm74 8322 4 0.0001 0.0001 CD cord-015021-pol2qm74 8322 5 ) ) -RRB- cord-015021-pol2qm74 8322 6 , , , cord-015021-pol2qm74 8322 7 circulating circulate VBG cord-015021-pol2qm74 8322 8 PLA2-activities pla2-activitie NNS cord-015021-pol2qm74 8322 9 range range VBP cord-015021-pol2qm74 8322 10 from from IN cord-015021-pol2qm74 8322 11 116.2 116.2 CD cord-015021-pol2qm74 8322 12 , , , cord-015021-pol2qm74 8323 1 SD=45.4 sd=45.4 VB cord-015021-pol2qm74 8323 2 to to IN cord-015021-pol2qm74 8323 3 185.4 185.4 CD cord-015021-pol2qm74 8323 4 U/1 u/1 NN cord-015021-pol2qm74 8323 5 , , , cord-015021-pol2qm74 8323 6 SD=105.4 SD=105.4 NNP cord-015021-pol2qm74 8323 7 ( ( -LRB- cord-015021-pol2qm74 8323 8 p p NN cord-015021-pol2qm74 8323 9 < < XX cord-015021-pol2qm74 8323 10 0.01 0.01 CD cord-015021-pol2qm74 8323 11 ) ) -RRB- cord-015021-pol2qm74 8324 1 and and CC cord-015021-pol2qm74 8324 2 biopterin biopterin NNP cord-015021-pol2qm74 8324 3 range range NN cord-015021-pol2qm74 8324 4 from from IN cord-015021-pol2qm74 8324 5 54.4 54.4 CD cord-015021-pol2qm74 8324 6 nmol nmol NNP cord-015021-pol2qm74 8324 7 / / SYM cord-015021-pol2qm74 8324 8 l l NNP cord-015021-pol2qm74 8324 9 SD=17.2 SD=17.2 NNP cord-015021-pol2qm74 8324 10 to to IN cord-015021-pol2qm74 8324 11 127.8 127.8 CD cord-015021-pol2qm74 8324 12 nmol nmol NNP cord-015021-pol2qm74 8324 13 / / SYM cord-015021-pol2qm74 8324 14 l l NN cord-015021-pol2qm74 8324 15 , , , cord-015021-pol2qm74 8324 16 SD=76.8 SD=76.8 NNP cord-015021-pol2qm74 8324 17 ( ( -LRB- cord-015021-pol2qm74 8324 18 p p NN cord-015021-pol2qm74 8324 19 < < XX cord-015021-pol2qm74 8324 20 0.001 0.001 CD cord-015021-pol2qm74 8324 21 ) ) -RRB- cord-015021-pol2qm74 8324 22 ] ] -RRB- cord-015021-pol2qm74 8324 23 . . . cord-015021-pol2qm74 8325 1 For for IN cord-015021-pol2qm74 8325 2 the the DT cord-015021-pol2qm74 8325 3 peritonitis peritonitis NN cord-015021-pol2qm74 8325 4 group group NN cord-015021-pol2qm74 8325 5 we -PRON- PRP cord-015021-pol2qm74 8325 6 found find VBD cord-015021-pol2qm74 8325 7 strong strong JJ cord-015021-pol2qm74 8325 8 correlations correlation NNS cord-015021-pol2qm74 8325 9 between between IN cord-015021-pol2qm74 8325 10 the the DT cord-015021-pol2qm74 8325 11 degree degree NN cord-015021-pol2qm74 8325 12 of of IN cord-015021-pol2qm74 8325 13 endotoxinaemia endotoxinaemia NN cord-015021-pol2qm74 8325 14 to to IN cord-015021-pol2qm74 8325 15 elevated elevated JJ cord-015021-pol2qm74 8325 16 levels level NNS cord-015021-pol2qm74 8325 17 of of IN cord-015021-pol2qm74 8325 18 IFN-'~ IFN-'~ NNP cord-015021-pol2qm74 8325 19 ( ( -LRB- cord-015021-pol2qm74 8325 20 rp rp NN cord-015021-pol2qm74 8325 21 = = NN cord-015021-pol2qm74 8325 22 0.72 0.72 CD cord-015021-pol2qm74 8325 23 , , , cord-015021-pol2qm74 8325 24 p p NN cord-015021-pol2qm74 8325 25 < < XX cord-015021-pol2qm74 8325 26 0.0001 0.0001 CD cord-015021-pol2qm74 8325 27 ) ) -RRB- cord-015021-pol2qm74 8325 28 and and CC cord-015021-pol2qm74 8325 29 bioptefin bioptefin NNP cord-015021-pol2qm74 8325 30 synthesis synthesis NNP cord-015021-pol2qm74 8325 31 ( ( -LRB- cord-015021-pol2qm74 8325 32 rv= rv= NNP cord-015021-pol2qm74 8325 33 0.82 0.82 CD cord-015021-pol2qm74 8325 34 , , , cord-015021-pol2qm74 8325 35 p p NN cord-015021-pol2qm74 8325 36 < < XX cord-015021-pol2qm74 8325 37 0.0001 0.0001 CD cord-015021-pol2qm74 8325 38 ) ) -RRB- cord-015021-pol2qm74 8325 39 . . . cord-015021-pol2qm74 8326 1 The the DT cord-015021-pol2qm74 8326 2 increase increase NN cord-015021-pol2qm74 8326 3 of of IN cord-015021-pol2qm74 8326 4 IFN IFN NNP cord-015021-pol2qm74 8326 5 - - HYPH cord-015021-pol2qm74 8326 6 T T NNP cord-015021-pol2qm74 8326 7 levels level NNS cord-015021-pol2qm74 8326 8 was be VBD cord-015021-pol2qm74 8326 9 correlated correlate VBN cord-015021-pol2qm74 8326 10 to to IN cord-015021-pol2qm74 8326 11 the the DT cord-015021-pol2qm74 8326 12 regulatory regulatory JJ cord-015021-pol2qm74 8326 13 synthesis synthesis NN cord-015021-pol2qm74 8326 14 of of IN cord-015021-pol2qm74 8326 15 biopterin biopterin NNP cord-015021-pol2qm74 8326 16 ( ( -LRB- cord-015021-pol2qm74 8326 17 r r NN cord-015021-pol2qm74 8326 18 = = NN cord-015021-pol2qm74 8326 19 0 0 CD cord-015021-pol2qm74 8326 20 73 73 CD cord-015021-pol2qm74 8326 21 p p NN cord-015021-pol2qm74 8326 22 < < XX cord-015021-pol2qm74 8326 23 . . . cord-015021-pol2qm74 8327 1 .. .. . cord-015021-pol2qm74 8328 1 P p NN cord-015021-pol2qm74 8328 2 • • NN cord-015021-pol2qm74 8328 3 , , , cord-015021-pol2qm74 8328 4 . . . cord-015021-pol2qm74 8329 1 0.0001 0.0001 LS cord-015021-pol2qm74 8329 2 ) ) -RRB- cord-015021-pol2qm74 8329 3 and and CC cord-015021-pol2qm74 8329 4 to to IN cord-015021-pol2qm74 8329 5 the the DT cord-015021-pol2qm74 8329 6 PLA2-actwtUes pla2-actwtues NN cord-015021-pol2qm74 8329 7 ( ( -LRB- cord-015021-pol2qm74 8329 8 rp rp NN cord-015021-pol2qm74 8329 9 = = NN cord-015021-pol2qm74 8329 10 0.50 0.50 CD cord-015021-pol2qm74 8329 11 , , , cord-015021-pol2qm74 8329 12 p p NN cord-015021-pol2qm74 8329 13 < < XX cord-015021-pol2qm74 8329 14 0.005 0.005 CD cord-015021-pol2qm74 8329 15 ) ) -RRB- cord-015021-pol2qm74 8329 16 . . . cord-015021-pol2qm74 8330 1 The the DT cord-015021-pol2qm74 8330 2 biopterin biopterin NNP cord-015021-pol2qm74 8330 3 synthes synthe NNS cord-015021-pol2qm74 8331 1 ~s ~s NNP cord-015021-pol2qm74 8331 2 correlates correlate VBZ cord-015021-pol2qm74 8331 3 slightly slightly RB cord-015021-pol2qm74 8331 4 with with IN cord-015021-pol2qm74 8331 5 the the DT cord-015021-pol2qm74 8331 6 PLA2-actn PLA2-actn NNP cord-015021-pol2qm74 8331 7 , , , cord-015021-pol2qm74 8331 8 ities itie NNS cord-015021-pol2qm74 8331 9 ( ( -LRB- cord-015021-pol2qm74 8331 10 rp= rp= NNP cord-015021-pol2qm74 8331 11 : : : cord-015021-pol2qm74 8331 12 0.38 0.38 CD cord-015021-pol2qm74 8331 13 ; ; . cord-015021-pol2qm74 8332 1 p p NN cord-015021-pol2qm74 8332 2 < < XX cord-015021-pol2qm74 8332 3 0.05 0.05 CD cord-015021-pol2qm74 8332 4 ) ) -RRB- cord-015021-pol2qm74 8332 5 . . . cord-015021-pol2qm74 8333 1 Using use VBG cord-015021-pol2qm74 8333 2 the the DT cord-015021-pol2qm74 8333 3 para para NNP cord-015021-pol2qm74 8333 4 , , , cord-015021-pol2qm74 8333 5 meters meter NNS cord-015021-pol2qm74 8333 6 of of IN cord-015021-pol2qm74 8333 7 endotoxin endotoxin NN cord-015021-pol2qm74 8333 8 , , , cord-015021-pol2qm74 8333 9 IFN IFN NNP cord-015021-pol2qm74 8333 10 - - HYPH cord-015021-pol2qm74 8333 11 y y NNP cord-015021-pol2qm74 8333 12 levels level NNS cord-015021-pol2qm74 8333 13 , , , cord-015021-pol2qm74 8333 14 biopterin biopterin NNP cord-015021-pol2qm74 8333 15 and and CC cord-015021-pol2qm74 8333 16 the the DT cord-015021-pol2qm74 8333 17 PLA~ PLA~ NNP cord-015021-pol2qm74 8333 18 -activities -activities NNP cord-015021-pol2qm74 8333 19 only only RB cord-015021-pol2qm74 8333 20 , , , cord-015021-pol2qm74 8333 21 the the DT cord-015021-pol2qm74 8333 22 statistical statistical JJ cord-015021-pol2qm74 8333 23 procedure procedure NN cord-015021-pol2qm74 8333 24 of of IN cord-015021-pol2qm74 8333 25 the the DT cord-015021-pol2qm74 8333 26 linear linear JJ cord-015021-pol2qm74 8333 27 discriminant discriminant NN cord-015021-pol2qm74 8333 28 analysis analysis NN cord-015021-pol2qm74 8333 29 makes make VBZ cord-015021-pol2qm74 8333 30 it -PRON- PRP cord-015021-pol2qm74 8333 31 possible possible JJ cord-015021-pol2qm74 8333 32 , , , cord-015021-pol2qm74 8333 33 to to TO cord-015021-pol2qm74 8333 34 distinguish distinguish VB cord-015021-pol2qm74 8333 35 between between IN cord-015021-pol2qm74 8333 36 non non JJ cord-015021-pol2qm74 8333 37 - - JJ cord-015021-pol2qm74 8333 38 septic septic JJ cord-015021-pol2qm74 8333 39 animals animal NNS cord-015021-pol2qm74 8333 40 and and CC cord-015021-pol2qm74 8333 41 septic septic JJ cord-015021-pol2qm74 8333 42 animals animal NNS cord-015021-pol2qm74 8333 43 correctly correctly RB cord-015021-pol2qm74 8333 44 at at IN cord-015021-pol2qm74 8333 45 a a DT cord-015021-pol2qm74 8333 46 rate rate NN cord-015021-pol2qm74 8333 47 of of IN cord-015021-pol2qm74 8333 48 87 87 CD cord-015021-pol2qm74 8333 49 % % NN cord-015021-pol2qm74 8333 50 . . . cord-015021-pol2qm74 8334 1 Anaerobes Anaerobes NNPS cord-015021-pol2qm74 8334 2 were be VBD cord-015021-pol2qm74 8334 3 found find VBN cord-015021-pol2qm74 8334 4 in in IN cord-015021-pol2qm74 8334 5 53.4 53.4 CD cord-015021-pol2qm74 8334 6 % % NN cord-015021-pol2qm74 8334 7 , , , cord-015021-pol2qm74 8334 8 anaerobes anaerobe NNS cord-015021-pol2qm74 8334 9 were be VBD cord-015021-pol2qm74 8334 10 isolated isolate VBN cord-015021-pol2qm74 8334 11 in in IN cord-015021-pol2qm74 8334 12 22.8 22.8 CD cord-015021-pol2qm74 8334 13 % % NN cord-015021-pol2qm74 8334 14 . . . cord-015021-pol2qm74 8335 1 There there EX cord-015021-pol2qm74 8335 2 were be VBD cord-015021-pol2qm74 8335 3 aerobic aerobic JJ cord-015021-pol2qm74 8335 4 and and CC cord-015021-pol2qm74 8335 5 anaerobic anaerobic JJ cord-015021-pol2qm74 8335 6 associations association NNS cord-015021-pol2qm74 8335 7 in in IN cord-015021-pol2qm74 8335 8 12.1 12.1 CD cord-015021-pol2qm74 8335 9 % % NN cord-015021-pol2qm74 8335 10 and and CC cord-015021-pol2qm74 8335 11 microflora microflora NN cord-015021-pol2qm74 8335 12 was be VBD cord-015021-pol2qm74 8335 13 not not RB cord-015021-pol2qm74 8335 14 found find VBN cord-015021-pol2qm74 8335 15 in in IN cord-015021-pol2qm74 8335 16 11.6 11.6 CD cord-015021-pol2qm74 8335 17 % % NN cord-015021-pol2qm74 8335 18 of of IN cord-015021-pol2qm74 8335 19 the the DT cord-015021-pol2qm74 8335 20 cases case NNS cord-015021-pol2qm74 8335 21 . . . cord-015021-pol2qm74 8336 1 Express express JJ cord-015021-pol2qm74 8336 2 method method NN cord-015021-pol2qm74 8336 3 of of IN cord-015021-pol2qm74 8336 4 anaerobes anaerobe NNS cord-015021-pol2qm74 8336 5 discovering discover VBG cord-015021-pol2qm74 8336 6 let let VBD cord-015021-pol2qm74 8336 7 to to TO cord-015021-pol2qm74 8336 8 receive receive VB cord-015021-pol2qm74 8336 9 information information NN cord-015021-pol2qm74 8336 10 on on IN cord-015021-pol2qm74 8336 11 1 1 CD cord-015021-pol2qm74 8336 12 -3 -3 NNP cord-015021-pol2qm74 8336 13 days day NNS cord-015021-pol2qm74 8336 14 early early RB cord-015021-pol2qm74 8336 15 than than IN cord-015021-pol2qm74 8336 16 in in IN cord-015021-pol2qm74 8336 17 generally generally RB cord-015021-pol2qm74 8336 18 accepted accept VBN cord-015021-pol2qm74 8336 19 nethods nethods NNP cord-015021-pol2qm74 8336 20 . . . cord-015021-pol2qm74 8337 1 Intraaotal Intraaotal NNP cord-015021-pol2qm74 8337 2 transfusion transfusion NN cord-015021-pol2qm74 8337 3 of of IN cord-015021-pol2qm74 8337 4 oxygenate oxygenate JJ cord-015021-pol2qm74 8337 5 blood blood NN cord-015021-pol2qm74 8337 6 and and CC cord-015021-pol2qm74 8337 7 laser laser NN cord-015021-pol2qm74 8337 8 irradiation irradiation NN cord-015021-pol2qm74 8337 9 of of IN cord-015021-pol2qm74 8337 10 blood blood NN cord-015021-pol2qm74 8337 11 reduces reduce VBZ cord-015021-pol2qm74 8337 12 the the DT cord-015021-pol2qm74 8337 13 duration duration NN cord-015021-pol2qm74 8337 14 of of IN cord-015021-pol2qm74 8337 15 anaerobic anaerobic JJ cord-015021-pol2qm74 8337 16 sow sow NN cord-015021-pol2qm74 8337 17 , , , cord-015021-pol2qm74 8337 18 disminishes disminishe NNS cord-015021-pol2qm74 8337 19 intoxication intoxication NN cord-015021-pol2qm74 8337 20 and and CC cord-015021-pol2qm74 8337 21 accelerate accelerate VB cord-015021-pol2qm74 8337 22 the the DT cord-015021-pol2qm74 8337 23 patients patient NNS cord-015021-pol2qm74 8337 24 recovery recovery NN cord-015021-pol2qm74 8337 25 . . . cord-015021-pol2qm74 8338 1 Patients patient NNS cord-015021-pol2qm74 8338 2 with with IN cord-015021-pol2qm74 8338 3 abdominal abdominal JJ cord-015021-pol2qm74 8338 4 sepsis sepsis NN cord-015021-pol2qm74 8338 5 are be VBP cord-015021-pol2qm74 8338 6 subject subject JJ cord-015021-pol2qm74 8338 7 to to IN cord-015021-pol2qm74 8338 8 long long JJ cord-015021-pol2qm74 8338 9 periods period NNS cord-015021-pol2qm74 8338 10 of of IN cord-015021-pol2qm74 8338 11 hospitalization hospitalization NN cord-015021-pol2qm74 8338 12 and and CC cord-015021-pol2qm74 8338 13 high high JJ cord-015021-pol2qm74 8338 14 associated associate VBN cord-015021-pol2qm74 8338 15 morbidity morbidity NN cord-015021-pol2qm74 8338 16 and and CC cord-015021-pol2qm74 8338 17 mortality mortality NN cord-015021-pol2qm74 8338 18 rates rate NNS cord-015021-pol2qm74 8338 19 . . . cord-015021-pol2qm74 8339 1 This this DT cord-015021-pol2qm74 8339 2 category category NN cord-015021-pol2qm74 8339 3 of of IN cord-015021-pol2qm74 8339 4 patients patient NNS cord-015021-pol2qm74 8339 5 is be VBZ cord-015021-pol2qm74 8339 6 thus thus RB cord-015021-pol2qm74 8339 7 consuming consume VBG cord-015021-pol2qm74 8339 8 extensive extensive JJ cord-015021-pol2qm74 8339 9 facilities facility NNS cord-015021-pol2qm74 8339 10 and and CC cord-015021-pol2qm74 8339 11 costs cost NNS cord-015021-pol2qm74 8339 12 . . . cord-015021-pol2qm74 8340 1 As as IN cord-015021-pol2qm74 8340 2 the the DT cord-015021-pol2qm74 8340 3 age age NN cord-015021-pol2qm74 8340 4 - - HYPH cord-015021-pol2qm74 8340 5 related relate VBN cord-015021-pol2qm74 8340 6 outcome outcome NN cord-015021-pol2qm74 8340 7 of of IN cord-015021-pol2qm74 8340 8 abdominal abdominal JJ cord-015021-pol2qm74 8340 9 sepsis sepsis NN cord-015021-pol2qm74 8340 10 is be VBZ cord-015021-pol2qm74 8340 11 not not RB cord-015021-pol2qm74 8340 12 fully fully RB cord-015021-pol2qm74 8340 13 known know VBN cord-015021-pol2qm74 8340 14 , , , cord-015021-pol2qm74 8340 15 the the DT cord-015021-pol2qm74 8340 16 aim aim NN cord-015021-pol2qm74 8340 17 of of IN cord-015021-pol2qm74 8340 18 the the DT cord-015021-pol2qm74 8340 19 present present JJ cord-015021-pol2qm74 8340 20 study study NN cord-015021-pol2qm74 8340 21 was be VBD cord-015021-pol2qm74 8340 22 to to TO cord-015021-pol2qm74 8340 23 investigate investigate VB cord-015021-pol2qm74 8340 24 abdominal abdominal JJ cord-015021-pol2qm74 8340 25 sepsis sepsis NN cord-015021-pol2qm74 8340 26 in in IN cord-015021-pol2qm74 8340 27 the the DT cord-015021-pol2qm74 8340 28 elderly elderly JJ cord-015021-pol2qm74 8340 29 . . . cord-015021-pol2qm74 8341 1 Out out IN cord-015021-pol2qm74 8341 2 of of IN cord-015021-pol2qm74 8341 3 166 166 CD cord-015021-pol2qm74 8341 4 patients patient NNS cord-015021-pol2qm74 8341 5 with with IN cord-015021-pol2qm74 8341 6 abdominal abdominal JJ cord-015021-pol2qm74 8341 7 sepsis sepsis NN cord-015021-pol2qm74 8341 8 treated treat VBN cord-015021-pol2qm74 8341 9 at at IN cord-015021-pol2qm74 8341 10 the the DT cord-015021-pol2qm74 8341 11 surgical surgical JJ cord-015021-pol2qm74 8341 12 intensive intensive JJ cord-015021-pol2qm74 8341 13 care care NN cord-015021-pol2qm74 8341 14 unit unit NN cord-015021-pol2qm74 8341 15 during during IN cord-015021-pol2qm74 8341 16 a a DT cord-015021-pol2qm74 8341 17 10-year 10-year CD cord-015021-pol2qm74 8341 18 period period NN cord-015021-pol2qm74 8341 19 , , , cord-015021-pol2qm74 8341 20 72 72 CD cord-015021-pol2qm74 8341 21 ( ( -LRB- cord-015021-pol2qm74 8341 22 43 43 CD cord-015021-pol2qm74 8341 23 % % NN cord-015021-pol2qm74 8341 24 ) ) -RRB- cord-015021-pol2qm74 8341 25 had have VBD cord-015021-pol2qm74 8341 26 an an DT cord-015021-pol2qm74 8341 27 age age NN cord-015021-pol2qm74 8341 28 of of IN cord-015021-pol2qm74 8341 29 70 70 CD cord-015021-pol2qm74 8341 30 years year NNS cord-015021-pol2qm74 8341 31 or or CC cord-015021-pol2qm74 8341 32 more more JJR cord-015021-pol2qm74 8341 33 . . . cord-015021-pol2qm74 8342 1 28 28 CD cord-015021-pol2qm74 8342 2 were be VBD cord-015021-pol2qm74 8343 1 women woman NNS cord-015021-pol2qm74 8343 2 and and CC cord-015021-pol2qm74 8343 3 44 44 CD cord-015021-pol2qm74 8343 4 were be VBD cord-015021-pol2qm74 8343 5 men man NNS cord-015021-pol2qm74 8343 6 , , , cord-015021-pol2qm74 8343 7 a a DT cord-015021-pol2qm74 8343 8 sex sex NN cord-015021-pol2qm74 8343 9 distribution distribution NN cord-015021-pol2qm74 8343 10 not not RB cord-015021-pol2qm74 8343 11 differing differ VBG cord-015021-pol2qm74 8343 12 with with IN cord-015021-pol2qm74 8343 13 patients patient NNS cord-015021-pol2qm74 8343 14 younger young JJR cord-015021-pol2qm74 8343 15 than than IN cord-015021-pol2qm74 8343 16 70 70 CD cord-015021-pol2qm74 8343 17 years year NNS cord-015021-pol2qm74 8343 18 . . . cord-015021-pol2qm74 8344 1 The the DT cord-015021-pol2qm74 8344 2 patients patient NNS cord-015021-pol2qm74 8344 3 were be VBD cord-015021-pol2qm74 8344 4 scored score VBN cord-015021-pol2qm74 8344 5 according accord VBG cord-015021-pol2qm74 8344 6 to to IN cord-015021-pol2qm74 8344 7 APACHE APACHE NNP cord-015021-pol2qm74 8344 8 II II NNP cord-015021-pol2qm74 8344 9 and and CC cord-015021-pol2qm74 8344 10 septic septic JJ cord-015021-pol2qm74 8344 11 severity severity NN cord-015021-pol2qm74 8344 12 score score NN cord-015021-pol2qm74 8344 13 ( ( -LRB- cord-015021-pol2qm74 8344 14 SSS SSS NNP cord-015021-pol2qm74 8344 15 ) ) -RRB- cord-015021-pol2qm74 8344 16 upon upon IN cord-015021-pol2qm74 8344 17 arrival arrival NN cord-015021-pol2qm74 8344 18 to to IN cord-015021-pol2qm74 8344 19 the the DT cord-015021-pol2qm74 8344 20 intensive intensive JJ cord-015021-pol2qm74 8344 21 care care NN cord-015021-pol2qm74 8344 22 unit unit NN cord-015021-pol2qm74 8344 23 . . . cord-015021-pol2qm74 8345 1 Bacterial bacterial JJ cord-015021-pol2qm74 8345 2 cultures culture NNS cord-015021-pol2qm74 8345 3 , , , cord-015021-pol2qm74 8345 4 the the DT cord-015021-pol2qm74 8345 5 occurrence occurrence NN cord-015021-pol2qm74 8345 6 of of IN cord-015021-pol2qm74 8345 7 organ organ NN cord-015021-pol2qm74 8345 8 failure failure NN cord-015021-pol2qm74 8345 9 , , , cord-015021-pol2qm74 8345 10 hospitalization hospitalization NN cord-015021-pol2qm74 8345 11 and and CC cord-015021-pol2qm74 8345 12 outcome outcome NN cord-015021-pol2qm74 8345 13 was be VBD cord-015021-pol2qm74 8345 14 noted note VBN cord-015021-pol2qm74 8345 15 . . . cord-015021-pol2qm74 8346 1 In in IN cord-015021-pol2qm74 8346 2 median median JJ cord-015021-pol2qm74 8346 3 two two CD cord-015021-pol2qm74 8346 4 operations operation NNS cord-015021-pol2qm74 8346 5 were be VBD cord-015021-pol2qm74 8346 6 performed perform VBN cord-015021-pol2qm74 8346 7 for for IN cord-015021-pol2qm74 8346 8 both both DT cord-015021-pol2qm74 8346 9 " " `` cord-015021-pol2qm74 8346 10 younger young JJR cord-015021-pol2qm74 8346 11 and and CC cord-015021-pol2qm74 8346 12 elderly elderly JJ cord-015021-pol2qm74 8346 13 " " '' cord-015021-pol2qm74 8346 14 patients patient NNS cord-015021-pol2qm74 8346 15 . . . cord-015021-pol2qm74 8347 1 The the DT cord-015021-pol2qm74 8347 2 median median JJ cord-015021-pol2qm74 8347 3 time time NN cord-015021-pol2qm74 8347 4 of of IN cord-015021-pol2qm74 8347 5 hospitalization hospitalization NN cord-015021-pol2qm74 8347 6 in in IN cord-015021-pol2qm74 8347 7 the the DT cord-015021-pol2qm74 8347 8 elderly elderly JJ cord-015021-pol2qm74 8347 9 was be VBD cord-015021-pol2qm74 8347 10 29 29 CD cord-015021-pol2qm74 8347 11 ( ( -LRB- cord-015021-pol2qm74 8347 12 -183 -183 NNP cord-015021-pol2qm74 8347 13 ) ) -RRB- cord-015021-pol2qm74 8347 14 days day NNS cord-015021-pol2qm74 8347 15 including include VBG cord-015021-pol2qm74 8347 16 in in IN cord-015021-pol2qm74 8347 17 median median JJ cord-015021-pol2qm74 8347 18 10 10 CD cord-015021-pol2qm74 8347 19 days day NNS cord-015021-pol2qm74 8347 20 in in IN cord-015021-pol2qm74 8347 21 the the DT cord-015021-pol2qm74 8347 22 ICU ICU NNP cord-015021-pol2qm74 8347 23 . . . cord-015021-pol2qm74 8348 1 Figures figure NNS cord-015021-pol2qm74 8348 2 in in IN cord-015021-pol2qm74 8348 3 patients patient NNS cord-015021-pol2qm74 8348 4 less less JJR cord-015021-pol2qm74 8348 5 than than IN cord-015021-pol2qm74 8348 6 70 70 CD cord-015021-pol2qm74 8348 7 years year NNS cord-015021-pol2qm74 8348 8 of of IN cord-015021-pol2qm74 8348 9 age age NN cord-015021-pol2qm74 8348 10 were be VBD cord-015021-pol2qm74 8348 11 comparable comparable JJ cord-015021-pol2qm74 8348 12 ( ( -LRB- cord-015021-pol2qm74 8348 13 34 34 CD cord-015021-pol2qm74 8348 14 ( ( -LRB- cord-015021-pol2qm74 8348 15 -293 -293 NNP cord-015021-pol2qm74 8348 16 ) ) -RRB- cord-015021-pol2qm74 8348 17 days day NNS cord-015021-pol2qm74 8348 18 out out IN cord-015021-pol2qm74 8348 19 of of IN cord-015021-pol2qm74 8348 20 which which WDT cord-015021-pol2qm74 8348 21 in in IN cord-015021-pol2qm74 8348 22 median median JJ cord-015021-pol2qm74 8348 23 10 10 CD cord-015021-pol2qm74 8348 24 days day NNS cord-015021-pol2qm74 8348 25 in in IN cord-015021-pol2qm74 8348 26 the the DT cord-015021-pol2qm74 8348 27 ICU ICU NNP cord-015021-pol2qm74 8348 28 ) ) -RRB- cord-015021-pol2qm74 8348 29 . . . cord-015021-pol2qm74 8349 1 APACHE APACHE NNP cord-015021-pol2qm74 8349 2 II II NNP cord-015021-pol2qm74 8349 3 and and CC cord-015021-pol2qm74 8349 4 SSS SSS NNP cord-015021-pol2qm74 8349 5 - - HYPH cord-015021-pol2qm74 8349 6 scores score NNS cord-015021-pol2qm74 8349 7 did do VBD cord-015021-pol2qm74 8349 8 not not RB cord-015021-pol2qm74 8349 9 significantly significantly RB cord-015021-pol2qm74 8349 10 differ differ VB cord-015021-pol2qm74 8349 11 ( ( -LRB- cord-015021-pol2qm74 8349 12 14.2 14.2 CD cord-015021-pol2qm74 8349 13 vs vs IN cord-015021-pol2qm74 8349 14 13 13 CD cord-015021-pol2qm74 8349 15 and and CC cord-015021-pol2qm74 8349 16 23.3 23.3 CD cord-015021-pol2qm74 8349 17 vs vs IN cord-015021-pol2qm74 8349 18 26.5 26.5 CD cord-015021-pol2qm74 8349 19 , , , cord-015021-pol2qm74 8349 20 respectively respectively RB cord-015021-pol2qm74 8349 21 ) ) -RRB- cord-015021-pol2qm74 8349 22 , , , cord-015021-pol2qm74 8349 23 between between IN cord-015021-pol2qm74 8349 24 the the DT cord-015021-pol2qm74 8349 25 groups group NNS cord-015021-pol2qm74 8349 26 . . . cord-015021-pol2qm74 8350 1 Neither neither DT cord-015021-pol2qm74 8350 2 did do VBD cord-015021-pol2qm74 8350 3 the the DT cord-015021-pol2qm74 8350 4 incidence incidence NN cord-015021-pol2qm74 8350 5 of of IN cord-015021-pol2qm74 8350 6 organ organ NN cord-015021-pol2qm74 8350 7 failure failure NN cord-015021-pol2qm74 8350 8 differ differ VBP cord-015021-pol2qm74 8350 9 ( ( -LRB- cord-015021-pol2qm74 8350 10 57/73 57/73 CD cord-015021-pol2qm74 8350 11 vs vs IN cord-015021-pol2qm74 8350 12 77/94 77/94 CD cord-015021-pol2qm74 8350 13 ) ) -RRB- cord-015021-pol2qm74 8350 14 . . . cord-015021-pol2qm74 8351 1 However however RB cord-015021-pol2qm74 8351 2 , , , cord-015021-pol2qm74 8351 3 the the DT cord-015021-pol2qm74 8351 4 incidence incidence NN cord-015021-pol2qm74 8351 5 of of IN cord-015021-pol2qm74 8351 6 multiple multiple JJ cord-015021-pol2qm74 8351 7 organ organ NN cord-015021-pol2qm74 8351 8 failure failure NN cord-015021-pol2qm74 8351 9 was be VBD cord-015021-pol2qm74 8351 10 significantly significantly RB cord-015021-pol2qm74 8351 11 lower low JJR cord-015021-pol2qm74 8351 12 in in IN cord-015021-pol2qm74 8351 13 elderly elderly JJ cord-015021-pol2qm74 8351 14 patients patient NNS cord-015021-pol2qm74 8351 15 ( ( -LRB- cord-015021-pol2qm74 8351 16 21/72 21/72 CD cord-015021-pol2qm74 8351 17 vs vs IN cord-015021-pol2qm74 8351 18 42/94 42/94 CD cord-015021-pol2qm74 8351 19 ( ( -LRB- cord-015021-pol2qm74 8351 20 p p NN cord-015021-pol2qm74 8351 21 < < XX cord-015021-pol2qm74 8351 22 0.001 0.001 CD cord-015021-pol2qm74 8351 23 ) ) -RRB- cord-015021-pol2qm74 8351 24 ) ) -RRB- cord-015021-pol2qm74 8351 25 . . . cord-015021-pol2qm74 8352 1 The the DT cord-015021-pol2qm74 8352 2 mortality mortality NN cord-015021-pol2qm74 8352 3 rate rate NN cord-015021-pol2qm74 8352 4 , , , cord-015021-pol2qm74 8352 5 however however RB cord-015021-pol2qm74 8352 6 , , , cord-015021-pol2qm74 8352 7 did do VBD cord-015021-pol2qm74 8352 8 not not RB cord-015021-pol2qm74 8352 9 differ differ VB cord-015021-pol2qm74 8352 10 between between IN cord-015021-pol2qm74 8352 11 the the DT cord-015021-pol2qm74 8352 12 groups group NNS cord-015021-pol2qm74 8352 13 ( ( -LRB- cord-015021-pol2qm74 8352 14 21/72 21/72 CD cord-015021-pol2qm74 8352 15 vs vs IN cord-015021-pol2qm74 8352 16 26/94 26/94 CD cord-015021-pol2qm74 8352 17 ) ) -RRB- cord-015021-pol2qm74 8352 18 . . . cord-015021-pol2qm74 8353 1 In in IN cord-015021-pol2qm74 8353 2 conclusion conclusion NN cord-015021-pol2qm74 8353 3 , , , cord-015021-pol2qm74 8353 4 severe severe JJ cord-015021-pol2qm74 8353 5 abdominal abdominal JJ cord-015021-pol2qm74 8353 6 sepsis sepsis NN cord-015021-pol2qm74 8353 7 in in IN cord-015021-pol2qm74 8353 8 the the DT cord-015021-pol2qm74 8353 9 elderly elderly JJ cord-015021-pol2qm74 8353 10 was be VBD cord-015021-pol2qm74 8353 11 not not RB cord-015021-pol2qm74 8353 12 associated associate VBN cord-015021-pol2qm74 8353 13 with with IN cord-015021-pol2qm74 8353 14 an an DT cord-015021-pol2qm74 8353 15 increase increase NN cord-015021-pol2qm74 8353 16 in in IN cord-015021-pol2qm74 8353 17 mortality mortality NN cord-015021-pol2qm74 8353 18 , , , cord-015021-pol2qm74 8353 19 incidence incidence NN cord-015021-pol2qm74 8353 20 of of IN cord-015021-pol2qm74 8353 21 organ organ NN cord-015021-pol2qm74 8353 22 failure failure NN cord-015021-pol2qm74 8353 23 or or CC cord-015021-pol2qm74 8353 24 hospital hospital NN cord-015021-pol2qm74 8353 25 stay stay NN cord-015021-pol2qm74 8353 26 . . . cord-015021-pol2qm74 8354 1 With with IN cord-015021-pol2qm74 8354 2 the the DT cord-015021-pol2qm74 8354 3 help help NN cord-015021-pol2qm74 8354 4 of of IN cord-015021-pol2qm74 8354 5 light light JJ cord-015021-pol2qm74 8354 6 transmissional transmissional JJ cord-015021-pol2qm74 8354 7 scanning scanning NN cord-015021-pol2qm74 8354 8 electron electron NN cord-015021-pol2qm74 8354 9 microscopy microscopy NN cord-015021-pol2qm74 8354 10 morphology morphology NN cord-015021-pol2qm74 8354 11 of of IN cord-015021-pol2qm74 8354 12 erythrosytes erythrosyte NNS cord-015021-pol2qm74 8354 13 of of IN cord-015021-pol2qm74 8354 14 peripheric peripheric JJ cord-015021-pol2qm74 8354 15 blood blood NN cord-015021-pol2qm74 8354 16 was be VBD cord-015021-pol2qm74 8354 17 studied study VBN cord-015021-pol2qm74 8354 18 in in IN cord-015021-pol2qm74 8354 19 patients patient NNS cord-015021-pol2qm74 8354 20 with with IN cord-015021-pol2qm74 8354 21 different different JJ cord-015021-pol2qm74 8354 22 stages stage NNS cord-015021-pol2qm74 8354 23 of of IN cord-015021-pol2qm74 8354 24 diffuse diffuse JJ cord-015021-pol2qm74 8354 25 peritonitis peritonitis NN cord-015021-pol2qm74 8354 26 before before IN cord-015021-pol2qm74 8354 27 and and CC cord-015021-pol2qm74 8354 28 after after IN cord-015021-pol2qm74 8354 29 intravascu!ar intravascu!ar JJ cord-015021-pol2qm74 8354 30 irradiation irradiation NN cord-015021-pol2qm74 8354 31 of of IN cord-015021-pol2qm74 8354 32 blood blood NN cord-015021-pol2qm74 8354 33 with with IN cord-015021-pol2qm74 8354 34 heliun heliun JJ cord-015021-pol2qm74 8354 35 - - HYPH cord-015021-pol2qm74 8354 36 neon neon NN cord-015021-pol2qm74 8354 37 laser laser NN cord-015021-pol2qm74 8354 38 . . . cord-015021-pol2qm74 8355 1 Peritoneal peritoneal JJ cord-015021-pol2qm74 8355 2 morphology morphology NN cord-015021-pol2qm74 8355 3 was be VBD cord-015021-pol2qm74 8355 4 investigated investigate VBN cord-015021-pol2qm74 8355 5 in in IN cord-015021-pol2qm74 8355 6 patients patient NNS cord-015021-pol2qm74 8355 7 who who WP cord-015021-pol2qm74 8355 8 died die VBD cord-015021-pol2qm74 8355 9 from from IN cord-015021-pol2qm74 8355 10 peritonitis peritonitis NN cord-015021-pol2qm74 8355 11 , , , cord-015021-pol2qm74 8355 12 It -PRON- PRP cord-015021-pol2qm74 8355 13 was be VBD cord-015021-pol2qm74 8355 14 established establish VBN cord-015021-pol2qm74 8355 15 that that IN cord-015021-pol2qm74 8355 16 in in IN cord-015021-pol2qm74 8355 17 all all DT cord-015021-pol2qm74 8355 18 phases phase NNS cord-015021-pol2qm74 8355 19 of of IN cord-015021-pol2qm74 8355 20 peritonitis peritonitis NN cord-015021-pol2qm74 8355 21 occured occur VBD cord-015021-pol2qm74 8355 22 stomatocytoric stomatocytoric NNP cord-015021-pol2qm74 8355 23 and and CC cord-015021-pol2qm74 8355 24 echinocytoric echinocytoric JJ cord-015021-pol2qm74 8355 25 transformation transformation NN cord-015021-pol2qm74 8355 26 of of IN cord-015021-pol2qm74 8355 27 erythrocytes erythrocyte NNS cord-015021-pol2qm74 8355 28 which which WDT cord-015021-pol2qm74 8355 29 progressed progress VBD cord-015021-pol2qm74 8355 30 simultaneously simultaneously RB cord-015021-pol2qm74 8355 31 with with IN cord-015021-pol2qm74 8355 32 increase increase NN cord-015021-pol2qm74 8355 33 of of IN cord-015021-pol2qm74 8355 34 intoxication intoxication NN cord-015021-pol2qm74 8355 35 . . . cord-015021-pol2qm74 8356 1 It -PRON- PRP cord-015021-pol2qm74 8356 2 combined combine VBD cord-015021-pol2qm74 8356 3 with with IN cord-015021-pol2qm74 8356 4 strongly strongly RB cord-015021-pol2qm74 8356 5 pronounced pronounce VBN cord-015021-pol2qm74 8356 6 vessels vessel NNS cord-015021-pol2qm74 8356 7 variability variability NN cord-015021-pol2qm74 8356 8 of of IN cord-015021-pol2qm74 8356 9 microcirculatory microcirculatory NNP cord-015021-pol2qm74 8356 10 peritoneal peritoneal NNP cord-015021-pol2qm74 8356 11 bed bed NNP cord-015021-pol2qm74 8356 12 which which WDT cord-015021-pol2qm74 8356 13 displaied displaie VBN cord-015021-pol2qm74 8356 14 by by IN cord-015021-pol2qm74 8356 15 erythrocytes erythrocyte NNS cord-015021-pol2qm74 8356 16 aggregation aggregation NN cord-015021-pol2qm74 8356 17 , , , cord-015021-pol2qm74 8356 18 stasis stasis NN cord-015021-pol2qm74 8356 19 and and CC cord-015021-pol2qm74 8356 20 microtrombogenesis microtrombogenesis NN cord-015021-pol2qm74 8356 21 . . . cord-015021-pol2qm74 8357 1 In in IN cord-015021-pol2qm74 8357 2 intravascular intravascular JJ cord-015021-pol2qm74 8357 3 laser laser NN cord-015021-pol2qm74 8357 4 irradiation irradiation NN cord-015021-pol2qm74 8357 5 of of IN cord-015021-pol2qm74 8357 6 blood blood NN cord-015021-pol2qm74 8357 7 number number NN cord-015021-pol2qm74 8357 8 of of IN cord-015021-pol2qm74 8357 9 erythrocytes erythrocyte NNS cord-015021-pol2qm74 8357 10 which which WDT cord-015021-pol2qm74 8357 11 underwent undergo VBD cord-015021-pol2qm74 8357 12 to to IN cord-015021-pol2qm74 8357 13 stomatocytoric stomatocytoric NNP cord-015021-pol2qm74 8357 14 and and CC cord-015021-pol2qm74 8357 15 echinooytorie echinooytorie NNP cord-015021-pol2qm74 8357 16 transformation transformation NN cord-015021-pol2qm74 8357 17 was be VBD cord-015021-pol2qm74 8357 18 lower low JJR cord-015021-pol2qm74 8357 19 than than IN cord-015021-pol2qm74 8357 20 in in IN cord-015021-pol2qm74 8357 21 patients patient NNS cord-015021-pol2qm74 8357 22 without without IN cord-015021-pol2qm74 8357 23 laser laser NN cord-015021-pol2qm74 8357 24 irradiation irradiation NN cord-015021-pol2qm74 8357 25 . . . cord-015021-pol2qm74 8358 1 It -PRON- PRP cord-015021-pol2qm74 8358 2 indicated indicate VBD cord-015021-pol2qm74 8358 3 that that IN cord-015021-pol2qm74 8358 4 the the DT cord-015021-pol2qm74 8358 5 intravascular intravascular JJ cord-015021-pol2qm74 8358 6 irradiation irradiation NN cord-015021-pol2qm74 8358 7 of of IN cord-015021-pol2qm74 8358 8 blood blood NN cord-015021-pol2qm74 8358 9 with with IN cord-015021-pol2qm74 8358 10 helium helium NN cord-015021-pol2qm74 8358 11 - - HYPH cord-015021-pol2qm74 8358 12 neon neon NN cord-015021-pol2qm74 8358 13 laser laser NN cord-015021-pol2qm74 8358 14 can can MD cord-015021-pol2qm74 8358 15 prevent prevent VB cord-015021-pol2qm74 8358 16 development development NN cord-015021-pol2qm74 8358 17 of of IN cord-015021-pol2qm74 8358 18 severe severe JJ cord-015021-pol2qm74 8358 19 alterations alteration NNS cord-015021-pol2qm74 8358 20 of of IN cord-015021-pol2qm74 8358 21 rheological rheological JJ cord-015021-pol2qm74 8358 22 property property NN cord-015021-pol2qm74 8358 23 of of IN cord-015021-pol2qm74 8358 24 blood blood NN cord-015021-pol2qm74 8358 25 and and CC cord-015021-pol2qm74 8358 26 consequently consequently RB cord-015021-pol2qm74 8358 27 variability variability NN cord-015021-pol2qm74 8358 28 of of IN cord-015021-pol2qm74 8358 29 microcirlatory microcirlatory NNP cord-015021-pol2qm74 8358 30 peritoneal peritoneal JJ cord-015021-pol2qm74 8358 31 bed bed NN cord-015021-pol2qm74 8358 32 in in IN cord-015021-pol2qm74 8358 33 patients patient NNS cord-015021-pol2qm74 8358 34 with with IN cord-015021-pol2qm74 8358 35 diffuse diffuse JJ cord-015021-pol2qm74 8358 36 peritonitis peritonitis NN cord-015021-pol2qm74 8358 37 . . . cord-015021-pol2qm74 8359 1 Abdominal abdominal JJ cord-015021-pol2qm74 8359 2 sepsis sepsis NN cord-015021-pol2qm74 8359 3 is be VBZ cord-015021-pol2qm74 8359 4 still still RB cord-015021-pol2qm74 8359 5 associated associate VBN cord-015021-pol2qm74 8359 6 with with IN cord-015021-pol2qm74 8359 7 high high JJ cord-015021-pol2qm74 8359 8 morbidity morbidity NN cord-015021-pol2qm74 8359 9 and and CC cord-015021-pol2qm74 8359 10 mortality mortality NN cord-015021-pol2qm74 8359 11 rates rate NNS cord-015021-pol2qm74 8359 12 , , , cord-015021-pol2qm74 8359 13 frequenfly frequenfly NN cord-015021-pol2qm74 8359 14 caused cause VBN cord-015021-pol2qm74 8359 15 by by IN cord-015021-pol2qm74 8359 16 multiple multiple JJ cord-015021-pol2qm74 8359 17 organ organ NN cord-015021-pol2qm74 8359 18 failure failure NN cord-015021-pol2qm74 8359 19 . . . cord-015021-pol2qm74 8360 1 It -PRON- PRP cord-015021-pol2qm74 8360 2 has have VBZ cord-015021-pol2qm74 8360 3 been be VBN cord-015021-pol2qm74 8360 4 reported report VBN cord-015021-pol2qm74 8360 5 that that IN cord-015021-pol2qm74 8360 6 changes change NNS cord-015021-pol2qm74 8360 7 in in IN cord-015021-pol2qm74 8360 8 capillary capillary JJ cord-015021-pol2qm74 8360 9 permeability permeability NN cord-015021-pol2qm74 8360 10 play play VBP cord-015021-pol2qm74 8360 11 a a DT cord-015021-pol2qm74 8360 12 role role NN cord-015021-pol2qm74 8360 13 in in IN cord-015021-pol2qm74 8360 14 the the DT cord-015021-pol2qm74 8360 15 pathogenesis pathogenesis NN cord-015021-pol2qm74 8360 16 of of IN cord-015021-pol2qm74 8360 17 multiple multiple JJ cord-015021-pol2qm74 8360 18 organ organ NN cord-015021-pol2qm74 8360 19 failure failure NN cord-015021-pol2qm74 8360 20 . . . cord-015021-pol2qm74 8361 1 The the DT cord-015021-pol2qm74 8361 2 present present JJ cord-015021-pol2qm74 8361 3 study study NN cord-015021-pol2qm74 8361 4 aimed aim VBN cord-015021-pol2qm74 8361 5 at at IN cord-015021-pol2qm74 8361 6 evaluating evaluate VBG cord-015021-pol2qm74 8361 7 the the DT cord-015021-pol2qm74 8361 8 influence influence NN cord-015021-pol2qm74 8361 9 of of IN cord-015021-pol2qm74 8361 10 intraabdominal intraabdominal JJ cord-015021-pol2qm74 8361 11 sepsis sepsis NN cord-015021-pol2qm74 8361 12 induced induce VBN cord-015021-pol2qm74 8361 13 by by IN cord-015021-pol2qm74 8361 14 cekal cekal JJ cord-015021-pol2qm74 8361 15 ligation ligation NN cord-015021-pol2qm74 8361 16 and and CC cord-015021-pol2qm74 8361 17 puncture puncture NN cord-015021-pol2qm74 8361 18 on on IN cord-015021-pol2qm74 8361 19 capillary capillary JJ cord-015021-pol2qm74 8361 20 permeability permeability NN cord-015021-pol2qm74 8361 21 in in IN cord-015021-pol2qm74 8361 22 multiple multiple JJ cord-015021-pol2qm74 8361 23 organs organ NNS cord-015021-pol2qm74 8361 24 and and CC cord-015021-pol2qm74 8361 25 tissues tissue NNS cord-015021-pol2qm74 8361 26 . . . cord-015021-pol2qm74 8362 1 96 96 CD cord-015021-pol2qm74 8362 2 adult adult NN cord-015021-pol2qm74 8362 3 male male JJ cord-015021-pol2qm74 8362 4 Sprague Sprague NNP cord-015021-pol2qm74 8362 5 - - HYPH cord-015021-pol2qm74 8362 6 Dawley Dawley NNP cord-015021-pol2qm74 8362 7 rats rat NNS cord-015021-pol2qm74 8362 8 were be VBD cord-015021-pol2qm74 8362 9 subjected subject VBN cord-015021-pol2qm74 8362 10 to to IN cord-015021-pol2qm74 8362 11 laparotomy laparotomy NN cord-015021-pol2qm74 8362 12 with with IN cord-015021-pol2qm74 8362 13 separation separation NN cord-015021-pol2qm74 8362 14 of of IN cord-015021-pol2qm74 8362 15 the the DT cord-015021-pol2qm74 8362 16 cekum cekum NNP cord-015021-pol2qm74 8362 17 ( ( -LRB- cord-015021-pol2qm74 8362 18 sham sham NNP cord-015021-pol2qm74 8362 19 operation operation NN cord-015021-pol2qm74 8362 20 ) ) -RRB- cord-015021-pol2qm74 8362 21 or or CC cord-015021-pol2qm74 8362 22 induction induction NN cord-015021-pol2qm74 8362 23 of of IN cord-015021-pol2qm74 8362 24 intraabdominal intraabdominal JJ cord-015021-pol2qm74 8362 25 sepsis sepsis NN cord-015021-pol2qm74 8362 26 by by IN cord-015021-pol2qm74 8362 27 cekal cekal NNP cord-015021-pol2qm74 8362 28 ligation ligation NNP cord-015021-pol2qm74 8362 29 and and CC cord-015021-pol2qm74 8362 30 puneatre puneatre NNP cord-015021-pol2qm74 8363 1 ( ( -LRB- cord-015021-pol2qm74 8363 2 n--48 n--48 NNP cord-015021-pol2qm74 8363 3 in in IN cord-015021-pol2qm74 8363 4 each each DT cord-015021-pol2qm74 8363 5 group group NN cord-015021-pol2qm74 8363 6 ) ) -RRB- cord-015021-pol2qm74 8363 7 . . . cord-015021-pol2qm74 8364 1 At at IN cord-015021-pol2qm74 8364 2 3 3 CD cord-015021-pol2qm74 8364 3 , , , cord-015021-pol2qm74 8364 4 6 6 CD cord-015021-pol2qm74 8364 5 , , , cord-015021-pol2qm74 8364 6 12 12 CD cord-015021-pol2qm74 8364 7 , , , cord-015021-pol2qm74 8364 8 24 24 CD cord-015021-pol2qm74 8364 9 , , , cord-015021-pol2qm74 8364 10 48 48 CD cord-015021-pol2qm74 8364 11 and and CC cord-015021-pol2qm74 8364 12 72 72 CD cord-015021-pol2qm74 8364 13 hours hour NNS cord-015021-pol2qm74 8364 14 ( ( -LRB- cord-015021-pol2qm74 8364 15 n=6 n=6 NNP cord-015021-pol2qm74 8364 16 / / SYM cord-015021-pol2qm74 8364 17 timepoint timepoint NN cord-015021-pol2qm74 8364 18 ) ) -RRB- cord-015021-pol2qm74 8364 19 , , , cord-015021-pol2qm74 8364 20 the the DT cord-015021-pol2qm74 8364 21 animals animal NNS cord-015021-pol2qm74 8364 22 were be VBD cord-015021-pol2qm74 8364 23 evaluated evaluate VBN cord-015021-pol2qm74 8364 24 concerning concern VBG cord-015021-pol2qm74 8364 25 mortality mortality NN cord-015021-pol2qm74 8364 26 and and CC cord-015021-pol2qm74 8364 27 capillary capillary JJ cord-015021-pol2qm74 8364 28 permeability permeability NN cord-015021-pol2qm74 8364 29 as as IN cord-015021-pol2qm74 8364 30 determined determine VBN cord-015021-pol2qm74 8364 31 by by IN cord-015021-pol2qm74 8364 32 the the DT cord-015021-pol2qm74 8364 33 passage passage NN cord-015021-pol2qm74 8364 34 of of IN cord-015021-pol2qm74 8364 35 : : : cord-015021-pol2qm74 8364 36 25I 25i LS cord-015021-pol2qm74 8364 37 - - HYPH cord-015021-pol2qm74 8364 38 labelled label VBN cord-015021-pol2qm74 8364 39 albumin albumin NN cord-015021-pol2qm74 8364 40 from from IN cord-015021-pol2qm74 8364 41 capillaries capillary NNS cord-015021-pol2qm74 8364 42 to to IN cord-015021-pol2qm74 8364 43 the the DT cord-015021-pol2qm74 8364 44 peritoneum peritoneum NN cord-015021-pol2qm74 8364 45 , , , cord-015021-pol2qm74 8364 46 the the DT cord-015021-pol2qm74 8364 47 proximal proximal JJ cord-015021-pol2qm74 8364 48 and and CC cord-015021-pol2qm74 8364 49 distal distal JJ cord-015021-pol2qm74 8364 50 small small JJ cord-015021-pol2qm74 8364 51 intestine intestine NN cord-015021-pol2qm74 8364 52 , , , cord-015021-pol2qm74 8364 53 cekum cekum NNP cord-015021-pol2qm74 8364 54 , , , cord-015021-pol2qm74 8364 55 colon colon NN cord-015021-pol2qm74 8364 56 , , , cord-015021-pol2qm74 8364 57 spleen spleen NNS cord-015021-pol2qm74 8364 58 , , , cord-015021-pol2qm74 8364 59 kidneys kidney NNS cord-015021-pol2qm74 8364 60 , , , cord-015021-pol2qm74 8364 61 lungs lung NNS cord-015021-pol2qm74 8364 62 . . . cord-015021-pol2qm74 8365 1 The the DT cord-015021-pol2qm74 8365 2 mortality mortality NN cord-015021-pol2qm74 8365 3 rate rate NN cord-015021-pol2qm74 8365 4 in in IN cord-015021-pol2qm74 8365 5 rats rat NNS cord-015021-pol2qm74 8365 6 with with IN cord-015021-pol2qm74 8365 7 intraabdominal intraabdominal JJ cord-015021-pol2qm74 8365 8 sepsis sepsis NN cord-015021-pol2qm74 8365 9 was be VBD cord-015021-pol2qm74 8365 10 33 33 CD cord-015021-pol2qm74 8365 11 % % NN cord-015021-pol2qm74 8365 12 both both DT cord-015021-pol2qm74 8365 13 at at IN cord-015021-pol2qm74 8365 14 48 48 CD cord-015021-pol2qm74 8365 15 and and CC cord-015021-pol2qm74 8365 16 72 72 CD cord-015021-pol2qm74 8365 17 hours hour NNS cord-015021-pol2qm74 8365 18 . . . cord-015021-pol2qm74 8366 1 Capillary capillary JJ cord-015021-pol2qm74 8366 2 permeability permeability NN cord-015021-pol2qm74 8366 3 in in IN cord-015021-pol2qm74 8366 4 the the DT cord-015021-pol2qm74 8366 5 peritoneum peritoneum NN cord-015021-pol2qm74 8366 6 , , , cord-015021-pol2qm74 8366 7 cekum cekum NNP cord-015021-pol2qm74 8366 8 , , , cord-015021-pol2qm74 8366 9 colon colon NN cord-015021-pol2qm74 8366 10 and and CC cord-015021-pol2qm74 8366 11 kidneys kidney NNS cord-015021-pol2qm74 8366 12 significantly significantly RB cord-015021-pol2qm74 8366 13 increased increase VBD cord-015021-pol2qm74 8366 14 from from IN cord-015021-pol2qm74 8366 15 6 6 CD cord-015021-pol2qm74 8366 16 hours hour NNS cord-015021-pol2qm74 8366 17 and and CC cord-015021-pol2qm74 8366 18 on on RB cord-015021-pol2qm74 8366 19 in in IN cord-015021-pol2qm74 8366 20 rats rat NNS cord-015021-pol2qm74 8366 21 with with IN cord-015021-pol2qm74 8366 22 intraabdominal intraabdominal JJ cord-015021-pol2qm74 8366 23 sepsis sepsis NN cord-015021-pol2qm74 8366 24 . . . cord-015021-pol2qm74 8367 1 In in IN cord-015021-pol2qm74 8367 2 septic septic JJ cord-015021-pol2qm74 8367 3 animals animal NNS cord-015021-pol2qm74 8367 4 , , , cord-015021-pol2qm74 8367 5 capillary capillary JJ cord-015021-pol2qm74 8367 6 permeability permeability NN cord-015021-pol2qm74 8367 7 in in IN cord-015021-pol2qm74 8367 8 the the DT cord-015021-pol2qm74 8367 9 lungs lung NNS cord-015021-pol2qm74 8367 10 and and CC cord-015021-pol2qm74 8367 11 spleen spleen NNS cord-015021-pol2qm74 8367 12 increased increase VBD cord-015021-pol2qm74 8367 13 from from IN cord-015021-pol2qm74 8367 14 12 12 CD cord-015021-pol2qm74 8367 15 hours hour NNS cord-015021-pol2qm74 8367 16 and and CC cord-015021-pol2qm74 8367 17 on on RB cord-015021-pol2qm74 8367 18 and and CC cord-015021-pol2qm74 8367 19 in in IN cord-015021-pol2qm74 8367 20 the the DT cord-015021-pol2qm74 8367 21 proximal proximal JJ cord-015021-pol2qm74 8367 22 and and CC cord-015021-pol2qm74 8367 23 distal distal JJ cord-015021-pol2qm74 8367 24 small small JJ cord-015021-pol2qm74 8367 25 intestine intestine NN cord-015021-pol2qm74 8367 26 from from IN cord-015021-pol2qm74 8367 27 24 24 CD cord-015021-pol2qm74 8367 28 hours hour NNS cord-015021-pol2qm74 8367 29 and and CC cord-015021-pol2qm74 8367 30 on on RB cord-015021-pol2qm74 8367 31 . . . cord-015021-pol2qm74 8368 1 Different different JJ cord-015021-pol2qm74 8368 2 types type NNS cord-015021-pol2qm74 8368 3 of of IN cord-015021-pol2qm74 8368 4 alterations alteration NNS cord-015021-pol2qm74 8368 5 in in IN cord-015021-pol2qm74 8368 6 capillary capillary JJ cord-015021-pol2qm74 8368 7 permeability permeability NN cord-015021-pol2qm74 8368 8 seem seem VBP cord-015021-pol2qm74 8368 9 to to TO cord-015021-pol2qm74 8368 10 appear appear VB cord-015021-pol2qm74 8368 11 : : : cord-015021-pol2qm74 8368 12 1 1 LS cord-015021-pol2qm74 8368 13 ) ) -RRB- cord-015021-pol2qm74 8368 14 a a DT cord-015021-pol2qm74 8368 15 temporary temporary JJ cord-015021-pol2qm74 8368 16 short short JJ cord-015021-pol2qm74 8368 17 increase increase NN cord-015021-pol2qm74 8368 18 e.g. e.g. RB cord-015021-pol2qm74 8368 19 in in IN cord-015021-pol2qm74 8368 20 the the DT cord-015021-pol2qm74 8368 21 proximal proximal JJ cord-015021-pol2qm74 8368 22 small small JJ cord-015021-pol2qm74 8368 23 intestine intestine NN cord-015021-pol2qm74 8368 24 and and CC cord-015021-pol2qm74 8368 25 spleen spleen NNS cord-015021-pol2qm74 8368 26 ; ; : cord-015021-pol2qm74 8368 27 2 2 LS cord-015021-pol2qm74 8368 28 ) ) -RRB- cord-015021-pol2qm74 8368 29 a a DT cord-015021-pol2qm74 8368 30 temporary temporary JJ cord-015021-pol2qm74 8368 31 longer long JJR cord-015021-pol2qm74 8368 32 increase increase NN cord-015021-pol2qm74 8368 33 e.g. e.g. RB cord-015021-pol2qm74 8368 34 in in IN cord-015021-pol2qm74 8368 35 the the DT cord-015021-pol2qm74 8368 36 colon colon NN cord-015021-pol2qm74 8368 37 and and CC cord-015021-pol2qm74 8368 38 kidneys kidney NNS cord-015021-pol2qm74 8368 39 ; ; : cord-015021-pol2qm74 8368 40 3 3 LS cord-015021-pol2qm74 8368 41 ) ) -RRB- cord-015021-pol2qm74 8368 42 a a DT cord-015021-pol2qm74 8368 43 persisting persist VBG cord-015021-pol2qm74 8368 44 increase increase NN cord-015021-pol2qm74 8368 45 e.g. e.g. RB cord-015021-pol2qm74 8368 46 in in IN cord-015021-pol2qm74 8368 47 the the DT cord-015021-pol2qm74 8368 48 peritoneum peritoneum NN cord-015021-pol2qm74 8368 49 , , , cord-015021-pol2qm74 8368 50 cekum cekum NNP cord-015021-pol2qm74 8368 51 , , , cord-015021-pol2qm74 8368 52 distal distal JJ cord-015021-pol2qm74 8368 53 small small JJ cord-015021-pol2qm74 8368 54 intestine intestine NN cord-015021-pol2qm74 8368 55 and and CC cord-015021-pol2qm74 8368 56 lungs lung NNS cord-015021-pol2qm74 8368 57 . . . cord-015021-pol2qm74 8369 1 We -PRON- PRP cord-015021-pol2qm74 8369 2 conclude conclude VBP cord-015021-pol2qm74 8369 3 that that IN cord-015021-pol2qm74 8369 4 experimentally experimentally RB cord-015021-pol2qm74 8369 5 induced induce VBN cord-015021-pol2qm74 8369 6 intraabdominal intraabdominal JJ cord-015021-pol2qm74 8369 7 sepsis sepsis NN cord-015021-pol2qm74 8369 8 induces induce VBZ cord-015021-pol2qm74 8369 9 early early JJ cord-015021-pol2qm74 8369 10 alterations alteration NNS cord-015021-pol2qm74 8369 11 in in IN cord-015021-pol2qm74 8369 12 capillary capillary JJ cord-015021-pol2qm74 8369 13 permeability permeability NN cord-015021-pol2qm74 8369 14 in in IN cord-015021-pol2qm74 8369 15 multiple multiple JJ cord-015021-pol2qm74 8369 16 organs organ NNS cord-015021-pol2qm74 8369 17 and and CC cord-015021-pol2qm74 8369 18 tissues tissue NNS cord-015021-pol2qm74 8369 19 . . . cord-015021-pol2qm74 8370 1 Such such JJ cord-015021-pol2qm74 8370 2 changes change NNS cord-015021-pol2qm74 8370 3 may may MD cord-015021-pol2qm74 8370 4 contribute contribute VB cord-015021-pol2qm74 8370 5 to to TO cord-015021-pol2qm74 8370 6 explain explain VB cord-015021-pol2qm74 8370 7 the the DT cord-015021-pol2qm74 8370 8 development development NN cord-015021-pol2qm74 8370 9 of of IN cord-015021-pol2qm74 8370 10 sepsis sepsis NN cord-015021-pol2qm74 8370 11 - - HYPH cord-015021-pol2qm74 8370 12 induced induce VBN cord-015021-pol2qm74 8370 13 multiple multiple JJ cord-015021-pol2qm74 8370 14 organ organ NN cord-015021-pol2qm74 8370 15 failure failure NN cord-015021-pol2qm74 8370 16 . . . cord-015021-pol2qm74 8371 1 Despite despite IN cord-015021-pol2qm74 8371 2 a a DT cord-015021-pol2qm74 8371 3 number number NN cord-015021-pol2qm74 8371 4 of of IN cord-015021-pol2qm74 8371 5 significant significant JJ cord-015021-pol2qm74 8371 6 advances advance NNS cord-015021-pol2qm74 8371 7 in in IN cord-015021-pol2qm74 8371 8 the the DT cord-015021-pol2qm74 8371 9 care care NN cord-015021-pol2qm74 8371 10 of of IN cord-015021-pol2qm74 8371 11 burn burn NN cord-015021-pol2qm74 8371 12 and and CC cord-015021-pol2qm74 8371 13 non non JJ cord-015021-pol2qm74 8371 14 - - JJ cord-015021-pol2qm74 8371 15 burn burn JJ cord-015021-pol2qm74 8371 16 traumatic traumatic JJ cord-015021-pol2qm74 8371 17 injury injury NN cord-015021-pol2qm74 8371 18 , , , cord-015021-pol2qm74 8371 19 infection infection NN cord-015021-pol2qm74 8371 20 and and CC cord-015021-pol2qm74 8371 21 sepsis sepsis NN cord-015021-pol2qm74 8371 22 remain remain VBP cord-015021-pol2qm74 8371 23 major major JJ cord-015021-pol2qm74 8371 24 causes cause NNS cord-015021-pol2qm74 8371 25 of of IN cord-015021-pol2qm74 8371 26 morbidity morbidity NN cord-015021-pol2qm74 8371 27 and and CC cord-015021-pol2qm74 8371 28 mortality mortality NN cord-015021-pol2qm74 8371 29 . . . cord-015021-pol2qm74 8372 1 The the DT cord-015021-pol2qm74 8372 2 severe severe JJ cord-015021-pol2qm74 8372 3 immunosuppresslon immunosuppresslon NN cord-015021-pol2qm74 8372 4 often often RB cord-015021-pol2qm74 8372 5 seen see VBN cord-015021-pol2qm74 8372 6 in in IN cord-015021-pol2qm74 8372 7 patients patient NNS cord-015021-pol2qm74 8372 8 with with IN cord-015021-pol2qm74 8372 9 severe severe JJ cord-015021-pol2qm74 8372 10 trauma trauma NN cord-015021-pol2qm74 8372 11 or or CC cord-015021-pol2qm74 8372 12 large large JJ cord-015021-pol2qm74 8372 13 burns burn NNS cord-015021-pol2qm74 8372 14 may may MD cord-015021-pol2qm74 8372 15 predispose predispose VB cord-015021-pol2qm74 8372 16 these these DT cord-015021-pol2qm74 8372 17 patients patient NNS cord-015021-pol2qm74 8372 18 to to IN cord-015021-pol2qm74 8372 19 life life NN cord-015021-pol2qm74 8372 20 threatening threaten VBG cord-015021-pol2qm74 8372 21 infections infection NNS cord-015021-pol2qm74 8372 22 . . . cord-015021-pol2qm74 8373 1 Included include VBN cord-015021-pol2qm74 8373 2 among among IN cord-015021-pol2qm74 8373 3 the the DT cord-015021-pol2qm74 8373 4 many many JJ cord-015021-pol2qm74 8373 5 Immune immune JJ cord-015021-pol2qm74 8373 6 alterations alteration NNS cord-015021-pol2qm74 8373 7 are be VBP cord-015021-pol2qm74 8373 8 changes change NNS cord-015021-pol2qm74 8373 9 In in IN cord-015021-pol2qm74 8373 10 the the DT cord-015021-pol2qm74 8373 11 Functional functional JJ cord-015021-pol2qm74 8373 12 capabilities capability NNS cord-015021-pol2qm74 8373 13 of of IN cord-015021-pol2qm74 8373 14 neutrophlls neutrophlls NNP cord-015021-pol2qm74 8373 15 ( ( -LRB- cord-015021-pol2qm74 8373 16 PMNs PMNs NNP cord-015021-pol2qm74 8373 17 ) ) -RRB- cord-015021-pol2qm74 8373 18 . . . cord-015021-pol2qm74 8374 1 We -PRON- PRP cord-015021-pol2qm74 8374 2 have have VBP cord-015021-pol2qm74 8374 3 examined examine VBN cord-015021-pol2qm74 8374 4 the the DT cord-015021-pol2qm74 8374 5 expression expression NN cord-015021-pol2qm74 8374 6 of of IN cord-015021-pol2qm74 8374 7 the the DT cord-015021-pol2qm74 8374 8 p p NN cord-015021-pol2qm74 8374 9 2 2 CD cord-015021-pol2qm74 8374 10 integrins integrin NNS cord-015021-pol2qm74 8374 11 ( ( -LRB- cord-015021-pol2qm74 8374 12 CD1 CD1 NNP cord-015021-pol2qm74 8374 13 l l NNP cord-015021-pol2qm74 8374 14 a a NNP cord-015021-pol2qm74 8374 15 , , , cord-015021-pol2qm74 8374 16 b b NN cord-015021-pol2qm74 8374 17 , , , cord-015021-pol2qm74 8374 18 c c NNP cord-015021-pol2qm74 8374 19 / / SYM cord-015021-pol2qm74 8374 20 CD18 CD18 NNP cord-015021-pol2qm74 8374 21 ) ) -RRB- cord-015021-pol2qm74 8374 22 , , , cord-015021-pol2qm74 8374 23 and and CC cord-015021-pol2qm74 8374 24 the the DT cord-015021-pol2qm74 8374 25 Fc'?R Fc'?R NNS cord-015021-pol2qm74 8374 26 ( ( -LRB- cord-015021-pol2qm74 8374 27 CD16 CD16 NNP cord-015021-pol2qm74 8374 28 , , , cord-015021-pol2qm74 8374 29 CD32 CD32 NNP cord-015021-pol2qm74 8374 30 , , , cord-015021-pol2qm74 8374 31 and and CC cord-015021-pol2qm74 8374 32 CD64 CD64 NNP cord-015021-pol2qm74 8374 33 ) ) -RRB- cord-015021-pol2qm74 8374 34 , , , cord-015021-pol2qm74 8374 35 as as RB cord-015021-pol2qm74 8374 36 well well RB cord-015021-pol2qm74 8374 37 as as IN cord-015021-pol2qm74 8374 38 several several JJ cord-015021-pol2qm74 8374 39 functional functional JJ cord-015021-pol2qm74 8374 40 parameters parameter NNS cord-015021-pol2qm74 8374 41 , , , cord-015021-pol2qm74 8374 42 on on IN cord-015021-pol2qm74 8374 43 PMNs pmn NNS cord-015021-pol2qm74 8374 44 from from IN cord-015021-pol2qm74 8374 45 thermal thermal JJ cord-015021-pol2qm74 8374 46 and and CC cord-015021-pol2qm74 8374 47 non non JJ cord-015021-pol2qm74 8374 48 - - JJ cord-015021-pol2qm74 8374 49 thermal thermal JJ cord-015021-pol2qm74 8374 50 traumatic traumatic JJ cord-015021-pol2qm74 8374 51 injury injury NN cord-015021-pol2qm74 8374 52 , , , cord-015021-pol2qm74 8374 53 PMNs PMNs NNP cord-015021-pol2qm74 8374 54 were be VBD cord-015021-pol2qm74 8374 55 obtained obtain VBN cord-015021-pol2qm74 8374 56 from from IN cord-015021-pol2qm74 8374 57 patients patient NNS cord-015021-pol2qm74 8374 58 sustaining sustain VBG cord-015021-pol2qm74 8374 59 severe severe JJ cord-015021-pol2qm74 8374 60 trauma trauma NN cord-015021-pol2qm74 8374 61 ( ( -LRB- cord-015021-pol2qm74 8374 62 initial initial JJ cord-015021-pol2qm74 8374 63 APACHE APACHE NNP cord-015021-pol2qm74 8374 64 II II NNP cord-015021-pol2qm74 8374 65 score score NN cord-015021-pol2qm74 8374 66 > > XX cord-015021-pol2qm74 8374 67 10 10 CD cord-015021-pol2qm74 8374 68 ) ) -RRB- cord-015021-pol2qm74 8374 69 or or CC cord-015021-pol2qm74 8374 70 thermal thermal JJ cord-015021-pol2qm74 8374 71 injury injury NN cord-015021-pol2qm74 8374 72 ( ( -LRB- cord-015021-pol2qm74 8374 73 > > NFP cord-015021-pol2qm74 8374 74 30~ 30~ CD cord-015021-pol2qm74 8374 75 total total JJ cord-015021-pol2qm74 8374 76 body body NN cord-015021-pol2qm74 8374 77 surface surface NN cord-015021-pol2qm74 8374 78 area area NN cord-015021-pol2qm74 8374 79 , , , cord-015021-pol2qm74 8374 80 15 15 CD cord-015021-pol2qm74 8374 81 % % NN cord-015021-pol2qm74 8374 82 full full JJ cord-015021-pol2qm74 8374 83 thickness thickness NN cord-015021-pol2qm74 8374 84 ) ) -RRB- cord-015021-pol2qm74 8374 85 , , , cord-015021-pol2qm74 8374 86 and and CC cord-015021-pol2qm74 8374 87 healthy healthy JJ cord-015021-pol2qm74 8374 88 controls control NNS cord-015021-pol2qm74 8374 89 . . . cord-015021-pol2qm74 8375 1 The the DT cord-015021-pol2qm74 8375 2 expression expression NN cord-015021-pol2qm74 8375 3 of of IN cord-015021-pol2qm74 8375 4 CD11 CD11 NNP cord-015021-pol2qm74 8375 5 b b NNP cord-015021-pol2qm74 8375 6 and and CC cord-015021-pol2qm74 8375 7 c c NN cord-015021-pol2qm74 8375 8 and and CC cord-015021-pol2qm74 8375 9 to to IN cord-015021-pol2qm74 8375 10 a a DT cord-015021-pol2qm74 8375 11 lesser less JJR cord-015021-pol2qm74 8375 12 degree degree NN cord-015021-pol2qm74 8375 13 CDI cdi NN cord-015021-pol2qm74 8375 14 1 1 CD cord-015021-pol2qm74 8375 15 a a DT cord-015021-pol2qm74 8375 16 was be VBD cord-015021-pol2qm74 8375 17 significantly significantly RB cord-015021-pol2qm74 8375 18 reduced reduce VBN cord-015021-pol2qm74 8375 19 on on IN cord-015021-pol2qm74 8375 20 PMNs pmn NNS cord-015021-pol2qm74 8375 21 . . . cord-015021-pol2qm74 8376 1 The the DT cord-015021-pol2qm74 8376 2 expression expression NN cord-015021-pol2qm74 8376 3 of of IN cord-015021-pol2qm74 8376 4 CD16 CD16 NNP cord-015021-pol2qm74 8376 5 and and CC cord-015021-pol2qm74 8376 6 CD32 CD32 NNP cord-015021-pol2qm74 8376 7 but but CC cord-015021-pol2qm74 8376 8 not not RB cord-015021-pol2qm74 8376 9 CD64 CD64 NNP cord-015021-pol2qm74 8376 10 was be VBD cord-015021-pol2qm74 8376 11 also also RB cord-015021-pol2qm74 8376 12 significantly significantly RB cord-015021-pol2qm74 8376 13 reduced reduce VBN cord-015021-pol2qm74 8376 14 . . . cord-015021-pol2qm74 8377 1 PMNs pmn NNS cord-015021-pol2qm74 8377 2 displaying display VBG cord-015021-pol2qm74 8377 3 this this DT cord-015021-pol2qm74 8377 4 reduction reduction NN cord-015021-pol2qm74 8378 1 In in IN cord-015021-pol2qm74 8378 2 receptor receptor NN cord-015021-pol2qm74 8378 3 expression expression NN cord-015021-pol2qm74 8378 4 have have VBP cord-015021-pol2qm74 8378 5 a a DT cord-015021-pol2qm74 8378 6 significantly significantly RB cord-015021-pol2qm74 8378 7 reduced reduce VBN cord-015021-pol2qm74 8378 8 ability ability NN cord-015021-pol2qm74 8378 9 to to IN cord-015021-pol2qm74 8378 10 phagocytose phagocytose JJ cord-015021-pol2qm74 8378 11 bacteria bacteria NNS cord-015021-pol2qm74 8378 12 and and CC cord-015021-pol2qm74 8378 13 undergo undergo VB cord-015021-pol2qm74 8378 14 the the DT cord-015021-pol2qm74 8378 15 oxidative oxidative JJ cord-015021-pol2qm74 8378 16 metabolic metabolic JJ cord-015021-pol2qm74 8378 17 burst burst NN cord-015021-pol2qm74 8378 18 response response NN cord-015021-pol2qm74 8378 19 . . . cord-015021-pol2qm74 8379 1 Thermal thermal JJ cord-015021-pol2qm74 8379 2 and and CC cord-015021-pol2qm74 8379 3 traumatic traumatic JJ cord-015021-pol2qm74 8379 4 injury injury NN cord-015021-pol2qm74 8379 5 result result NN cord-015021-pol2qm74 8380 1 In in IN cord-015021-pol2qm74 8380 2 global global JJ cord-015021-pol2qm74 8380 3 reduction reduction NN cord-015021-pol2qm74 8380 4 in in IN cord-015021-pol2qm74 8380 5 the the DT cord-015021-pol2qm74 8380 6 expression expression NN cord-015021-pol2qm74 8380 7 of of IN cord-015021-pol2qm74 8380 8 132 132 CD cord-015021-pol2qm74 8380 9 integrins integrin NNS cord-015021-pol2qm74 8380 10 and and CC cord-015021-pol2qm74 8380 11 FoR for IN cord-015021-pol2qm74 8380 12 which which WDT cord-015021-pol2qm74 8380 13 may may MD cord-015021-pol2qm74 8380 14 lead lead VB cord-015021-pol2qm74 8380 15 to to IN cord-015021-pol2qm74 8380 16 decreased decrease VBN cord-015021-pol2qm74 8380 17 functional functional JJ cord-015021-pol2qm74 8380 18 capabilities capability NNS cord-015021-pol2qm74 8380 19 , , , cord-015021-pol2qm74 8380 20 These these DT cord-015021-pol2qm74 8380 21 abnormalities abnormality NNS cord-015021-pol2qm74 8380 22 may may MD cord-015021-pol2qm74 8380 23 In in IN cord-015021-pol2qm74 8380 24 turn turn NN cord-015021-pol2qm74 8380 25 account account NN cord-015021-pol2qm74 8381 1 at at IN cord-015021-pol2qm74 8381 2 least least JJS cord-015021-pol2qm74 8381 3 In in IN cord-015021-pol2qm74 8381 4 part part NN cord-015021-pol2qm74 8381 5 for for IN cord-015021-pol2qm74 8381 6 the the DT cord-015021-pol2qm74 8381 7 Increased increase VBN cord-015021-pol2qm74 8381 8 rate rate NN cord-015021-pol2qm74 8381 9 of of IN cord-015021-pol2qm74 8381 10 Infection infection NN cord-015021-pol2qm74 8381 11 in in IN cord-015021-pol2qm74 8381 12 these these DT cord-015021-pol2qm74 8381 13 patlems patlem NNS cord-015021-pol2qm74 8381 14 , , , cord-015021-pol2qm74 8381 15 Institute Institute NNP cord-015021-pol2qm74 8381 16 , , , cord-015021-pol2qm74 8381 17 Dept Dept NNP cord-015021-pol2qm74 8381 18 . . NNP cord-015021-pol2qm74 8381 19 of of IN cord-015021-pol2qm74 8381 20 Surgery surgery NN cord-015021-pol2qm74 8381 21 , , , cord-015021-pol2qm74 8381 22 2~1 2~1 CD cord-015021-pol2qm74 8381 23 8ethesda 8ethesda CD cord-015021-pol2qm74 8381 24 Ave Ave NNP cord-015021-pol2qm74 8381 25 , , , cord-015021-pol2qm74 8381 26 Cincinnalt Cincinnalt NNP cord-015021-pol2qm74 8381 27 , , , cord-015021-pol2qm74 8381 28 OH oh UH cord-015021-pol2qm74 8381 29 , , , cord-015021-pol2qm74 8381 30 USA USA NNP cord-015021-pol2qm74 8381 31 , , , cord-015021-pol2qm74 8381 32 45267 45267 CD cord-015021-pol2qm74 8381 33 - - SYM cord-015021-pol2qm74 8381 34 0S5B 0s5b CD cord-015021-pol2qm74 8381 35 , , , cord-015021-pol2qm74 8381 36 Antibiotic antibiotic JJ cord-015021-pol2qm74 8381 37 - - HYPH cord-015021-pol2qm74 8381 38 phagocytic phagocytic JJ cord-015021-pol2qm74 8381 39 cell cell NN cord-015021-pol2qm74 8381 40 interactions interaction NNS cord-015021-pol2qm74 8381 41 : : : cord-015021-pol2qm74 8381 42 their -PRON- PRP$ cord-015021-pol2qm74 8381 43 effect effect NN cord-015021-pol2qm74 8381 44 on on IN cord-015021-pol2qm74 8381 45 endotoxin endotoxin NN cord-015021-pol2qm74 8381 46 release release NN cord-015021-pol2qm74 8381 47 . . . cord-015021-pol2qm74 8382 1 C c NN cord-015021-pol2qm74 8382 2 G g NN cord-015021-pol2qm74 8382 3 C c NN cord-015021-pol2qm74 8382 4 - - HYPH cord-015021-pol2qm74 8382 5 emmet1 emmet1 NN cord-015021-pol2qm74 8382 6 , , , cord-015021-pol2qm74 8382 7 Dep[Baeteriolog.z dep[baeteriolog.z NN cord-015021-pol2qm74 8382 8 , , , cord-015021-pol2qm74 8382 9 Univer_sitv univer_sitv NN cord-015021-pol2qm74 8382 10 of of IN cord-015021-pol2qm74 8382 11 Glasgow Glasgow NNP cord-015021-pol2qm74 8382 12 , , , cord-015021-pol2qm74 8383 1 Scotlan~_d Scotlan~_d NNP cord-015021-pol2qm74 8384 1 Increasingly increasingly RB cord-015021-pol2qm74 8384 2 it -PRON- PRP cord-015021-pol2qm74 8384 3 is be VBZ cord-015021-pol2qm74 8384 4 recognised recognise VBN cord-015021-pol2qm74 8384 5 that that IN cord-015021-pol2qm74 8384 6 pathogenic pathogenic JJ cord-015021-pol2qm74 8384 7 bacteria bacteria NNS cord-015021-pol2qm74 8384 8 are be VBP cord-015021-pol2qm74 8384 9 capable capable JJ cord-015021-pol2qm74 8384 10 of of IN cord-015021-pol2qm74 8384 11 surviving survive VBG cord-015021-pol2qm74 8384 12 intracellularly intracellularly RB cord-015021-pol2qm74 8384 13 within within IN cord-015021-pol2qm74 8384 14 phagocytic phagocytic JJ cord-015021-pol2qm74 8384 15 cells cell NNS cord-015021-pol2qm74 8384 16 in in IN cord-015021-pol2qm74 8384 17 addition addition NN cord-015021-pol2qm74 8384 18 to to IN cord-015021-pol2qm74 8384 19 their -PRON- PRP$ cord-015021-pol2qm74 8384 20 capacity capacity NN cord-015021-pol2qm74 8384 21 to to TO cord-015021-pol2qm74 8384 22 produce produce VB cord-015021-pol2qm74 8384 23 disease disease NN cord-015021-pol2qm74 8384 24 whilst whilst IN cord-015021-pol2qm74 8384 25 in in IN cord-015021-pol2qm74 8384 26 the the DT cord-015021-pol2qm74 8384 27 extracellular extracellular JJ cord-015021-pol2qm74 8384 28 milieu milieu NN cord-015021-pol2qm74 8384 29 . . . cord-015021-pol2qm74 8385 1 As as RB cord-015021-pol2qm74 8385 2 well well RB cord-015021-pol2qm74 8385 3 as as IN cord-015021-pol2qm74 8385 4 providing provide VBG cord-015021-pol2qm74 8385 5 protection protection NN cord-015021-pol2qm74 8385 6 from from IN cord-015021-pol2qm74 8385 7 certain certain JJ cord-015021-pol2qm74 8385 8 antibiotics antibiotic NNS cord-015021-pol2qm74 8385 9 which which WDT cord-015021-pol2qm74 8385 10 fail fail VBP cord-015021-pol2qm74 8385 11 to to TO cord-015021-pol2qm74 8385 12 penetrate penetrate VB cord-015021-pol2qm74 8385 13 the the DT cord-015021-pol2qm74 8385 14 phagocyte phagocyte NNS cord-015021-pol2qm74 8385 15 , , , cord-015021-pol2qm74 8385 16 such such JJ cord-015021-pol2qm74 8385 17 intraceltular intraceltular JJ cord-015021-pol2qm74 8385 18 bacteria bacteria NNS cord-015021-pol2qm74 8385 19 may may MD cord-015021-pol2qm74 8385 20 be be VB cord-015021-pol2qm74 8385 21 transported transport VBN cord-015021-pol2qm74 8385 22 from from IN cord-015021-pol2qm74 8385 23 the the DT cord-015021-pol2qm74 8385 24 initial initial JJ cord-015021-pol2qm74 8385 25 site site NN cord-015021-pol2qm74 8385 26 of of IN cord-015021-pol2qm74 8385 27 infection infection NN cord-015021-pol2qm74 8385 28 to to IN cord-015021-pol2qm74 8385 29 a a DT cord-015021-pol2qm74 8385 30 distant distant JJ cord-015021-pol2qm74 8385 31 more more RBR cord-015021-pol2qm74 8385 32 vulnerable vulnerable JJ cord-015021-pol2qm74 8385 33 body body NN cord-015021-pol2qm74 8385 34 site site NN cord-015021-pol2qm74 8385 35 wherein wherein WRB cord-015021-pol2qm74 8385 36 they -PRON- PRP cord-015021-pol2qm74 8385 37 may may MD cord-015021-pol2qm74 8385 38 proliferate proliferate VB cord-015021-pol2qm74 8385 39 . . . cord-015021-pol2qm74 8386 1 It -PRON- PRP cord-015021-pol2qm74 8386 2 is be VBZ cord-015021-pol2qm74 8386 3 also also RB cord-015021-pol2qm74 8386 4 known know VBN cord-015021-pol2qm74 8386 5 that that IN cord-015021-pol2qm74 8386 6 some some DT cord-015021-pol2qm74 8386 7 antibiotics antibiotic NNS cord-015021-pol2qm74 8386 8 are be VBP cord-015021-pol2qm74 8386 9 capable capable JJ cord-015021-pol2qm74 8386 10 of of IN cord-015021-pol2qm74 8386 11 becoming become VBG cord-015021-pol2qm74 8386 12 concentrated concentrated JJ cord-015021-pol2qm74 8386 13 within within IN cord-015021-pol2qm74 8386 14 phagocytic phagocytic JJ cord-015021-pol2qm74 8386 15 cells cell NNS cord-015021-pol2qm74 8386 16 mid mid IN cord-015021-pol2qm74 8386 17 displaying display VBG cord-015021-pol2qm74 8386 18 bioactivity bioactivity NN cord-015021-pol2qm74 8386 19 therein therein RB cord-015021-pol2qm74 8386 20 . . . cord-015021-pol2qm74 8387 1 Such such JJ cord-015021-pol2qm74 8387 2 bioactivity bioactivity NN cord-015021-pol2qm74 8387 3 might may MD cord-015021-pol2qm74 8387 4 be be VB cord-015021-pol2qm74 8387 5 responsible responsible JJ cord-015021-pol2qm74 8387 6 for for IN cord-015021-pol2qm74 8387 7 the the DT cord-015021-pol2qm74 8387 8 release release NN cord-015021-pol2qm74 8387 9 of of IN cord-015021-pol2qm74 8387 10 endotoxia endotoxia NN cord-015021-pol2qm74 8387 11 # # $ cord-015021-pol2qm74 8387 12 orn orn VBN cord-015021-pol2qm74 8387 13 gram gram NN cord-015021-pol2qm74 8387 14 - - HYPH cord-015021-pol2qm74 8387 15 negative negative JJ cord-015021-pol2qm74 8387 16 bacteria bacteria NNS cord-015021-pol2qm74 8387 17 which which WDT cord-015021-pol2qm74 8387 18 when when WRB cord-015021-pol2qm74 8387 19 liberated liberate VBN cord-015021-pol2qm74 8387 20 from from IN cord-015021-pol2qm74 8387 21 the the DT cord-015021-pol2qm74 8387 22 celt celt NN cord-015021-pol2qm74 8387 23 could could MD cord-015021-pol2qm74 8387 24 ~gger ~gger NNP cord-015021-pol2qm74 8387 25 the the DT cord-015021-pol2qm74 8387 26 cytokine cytokine NN cord-015021-pol2qm74 8387 27 cascade cascade NN cord-015021-pol2qm74 8387 28 . . . cord-015021-pol2qm74 8388 1 Anfib Anfib NNP cord-015021-pol2qm74 8388 2 , , , cord-015021-pol2qm74 8388 3 . . . cord-015021-pol2qm74 8389 1 ' ' `` cord-015021-pol2qm74 8389 2 otic otic NN cord-015021-pol2qm74 8389 3 - - HYPH cord-015021-pol2qm74 8389 4 induced induce VBN cord-015021-pol2qm74 8389 5 damage damage NN cord-015021-pol2qm74 8389 6 to to IN cord-015021-pol2qm74 8389 7 the the DT cord-015021-pol2qm74 8389 8 ultrastructure ultrastructure NN cord-015021-pol2qm74 8389 9 of of IN cord-015021-pol2qm74 8389 10 bacteria bacteria NNS cord-015021-pol2qm74 8389 11 can can MD cord-015021-pol2qm74 8389 12 also also RB cord-015021-pol2qm74 8389 13 occur occur VB cord-015021-pol2qm74 8389 14 when when WRB cord-015021-pol2qm74 8389 15 the the DT cord-015021-pol2qm74 8389 16 target target NN cord-015021-pol2qm74 8389 17 bacteria bacteria NNS cord-015021-pol2qm74 8389 18 are be VBP cord-015021-pol2qm74 8389 19 exposed expose VBN cord-015021-pol2qm74 8389 20 to to IN cord-015021-pol2qm74 8389 21 low low JJ cord-015021-pol2qm74 8389 22 ( ( -LRB- cord-015021-pol2qm74 8389 23 sub sub NN cord-015021-pol2qm74 8389 24 - - HYPH cord-015021-pol2qm74 8389 25 MIC MIC NNP cord-015021-pol2qm74 8389 26 ) ) -RRB- cord-015021-pol2qm74 8389 27 concentrations concentration NNS cord-015021-pol2qm74 8389 28 of of IN cord-015021-pol2qm74 8389 29 certain certain JJ cord-015021-pol2qm74 8389 30 drugs drug NNS cord-015021-pol2qm74 8389 31 . . . cord-015021-pol2qm74 8390 1 Such such JJ cord-015021-pol2qm74 8390 2 bacteria bacteria NNS cord-015021-pol2qm74 8390 3 may may MD cord-015021-pol2qm74 8390 4 present present VB cord-015021-pol2qm74 8390 5 quite quite RB cord-015021-pol2qm74 8390 6 altered alter VBN cord-015021-pol2qm74 8390 7 surface surface NN cord-015021-pol2qm74 8390 8 components component NNS cord-015021-pol2qm74 8390 9 m m NNP cord-015021-pol2qm74 8390 10 host host NN cord-015021-pol2qm74 8390 11 - - HYPH cord-015021-pol2qm74 8390 12 defense defense NN cord-015021-pol2qm74 8390 13 cells cell NNS cord-015021-pol2qm74 8390 14 as as RB cord-015021-pol2qm74 8390 15 well well RB cord-015021-pol2qm74 8390 16 as as IN cord-015021-pol2qm74 8390 17 releasing release VBG cord-015021-pol2qm74 8390 18 biologically biologically RB cord-015021-pol2qm74 8390 19 active active JJ cord-015021-pol2qm74 8390 20 ceil ceil NN cord-015021-pol2qm74 8390 21 wall wall NN cord-015021-pol2qm74 8390 22 components component NNS cord-015021-pol2qm74 8390 23 such such JJ cord-015021-pol2qm74 8390 24 as as IN cord-015021-pol2qm74 8390 25 endotoxin endotoxin NN cord-015021-pol2qm74 8390 26 . . . cord-015021-pol2qm74 8391 1 The the DT cord-015021-pol2qm74 8391 2 nature nature NN cord-015021-pol2qm74 8391 3 of of IN cord-015021-pol2qm74 8391 4 these these DT cord-015021-pol2qm74 8391 5 interactions interaction NNS cord-015021-pol2qm74 8391 6 at at IN cord-015021-pol2qm74 8391 7 the the DT cord-015021-pol2qm74 8391 8 cellular cellular JJ cord-015021-pol2qm74 8391 9 level level NN cord-015021-pol2qm74 8391 10 as as RB cord-015021-pol2qm74 8391 11 well well RB cord-015021-pol2qm74 8391 12 as as IN cord-015021-pol2qm74 8391 13 the the DT cord-015021-pol2qm74 8391 14 consequences consequence NNS cord-015021-pol2qm74 8391 15 for for IN cord-015021-pol2qm74 8391 16 the the DT cord-015021-pol2qm74 8391 17 host host NN cord-015021-pol2qm74 8391 18 will will MD cord-015021-pol2qm74 8391 19 be be VB cord-015021-pol2qm74 8391 20 discussed discuss VBN cord-015021-pol2qm74 8391 21 . . . cord-015021-pol2qm74 8392 1 New New NNP cord-015021-pol2qm74 8392 2 Jersey Jersey NNP cord-015021-pol2qm74 8392 3 Medical Medical NNP cord-015021-pol2qm74 8392 4 School School NNP cord-015021-pol2qm74 8392 5 : : : cord-015021-pol2qm74 8392 6 UMD UMD NNP cord-015021-pol2qm74 8392 7 , , , cord-015021-pol2qm74 8392 8 Newark Newark NNP cord-015021-pol2qm74 8392 9 , , , cord-015021-pol2qm74 8392 10 NJ NJ NNP cord-015021-pol2qm74 8392 11 07107 07107 CD cord-015021-pol2qm74 8393 1 A a DT cord-015021-pol2qm74 8393 2 technique technique NN cord-015021-pol2qm74 8393 3 of of IN cord-015021-pol2qm74 8393 4 physiologic physiologic JJ cord-015021-pol2qm74 8393 5 state state NN cord-015021-pol2qm74 8393 6 classification classification NN cord-015021-pol2qm74 8393 7 has have VBZ cord-015021-pol2qm74 8393 8 been be VBN cord-015021-pol2qm74 8393 9 developed develop VBN cord-015021-pol2qm74 8393 10 based base VBN cord-015021-pol2qm74 8393 11 on on IN cord-015021-pol2qm74 8393 12 the the DT cord-015021-pol2qm74 8393 13 m m NNP cord-015021-pol2qm74 8393 14 ~ ~ NFP cord-015021-pol2qm74 8393 15 itlvariable itlvariable NNP cord-015021-pol2qm74 8393 16 analysis analysis NN cord-015021-pol2qm74 8393 17 of of IN cord-015021-pol2qm74 8393 18 patient patient JJ cord-015021-pol2qm74 8393 19 derived derive VBN cord-015021-pol2qm74 8393 20 data data NN cord-015021-pol2qm74 8393 21 sets set NNS cord-015021-pol2qm74 8393 22 of of IN cord-015021-pol2qm74 8393 23 seventeen seventeen CD cord-015021-pol2qm74 8393 24 physiologic physiologic JJ cord-015021-pol2qm74 8393 25 variables variable NNS cord-015021-pol2qm74 8393 26 . . . cord-015021-pol2qm74 8394 1 These these DT cord-015021-pol2qm74 8394 2 multivariable multivariable JJ cord-015021-pol2qm74 8394 3 data data NN cord-015021-pol2qm74 8394 4 sets set NNS cord-015021-pol2qm74 8394 5 obtained obtain VBN cord-015021-pol2qm74 8394 6 from from IN cord-015021-pol2qm74 8394 7 critically critically RB cord-015021-pol2qm74 8394 8 ill ill JJ cord-015021-pol2qm74 8394 9 patients patient NNS cord-015021-pol2qm74 8394 10 requiring require VBG cord-015021-pol2qm74 8394 11 Intensive intensive JJ cord-015021-pol2qm74 8394 12 care care NN cord-015021-pol2qm74 8394 13 , , , cord-015021-pol2qm74 8394 14 were be VBD cord-015021-pol2qm74 8394 15 aormallsed aormallse VBN cord-015021-pol2qm74 8394 16 by by IN cord-015021-pol2qm74 8394 17 the the DT cord-015021-pol2qm74 8394 18 mean mean NN cord-015021-pol2qm74 8394 19 and and CC cord-015021-pol2qm74 8394 20 the the DT cord-015021-pol2qm74 8394 21 standard standard JJ cord-015021-pol2qm74 8394 22 deviation deviation NN cord-015021-pol2qm74 8394 23 of of IN cord-015021-pol2qm74 8394 24 recoverin~ recoverin~ NNP cord-015021-pol2qm74 8394 25 Trauma trauma NN cord-015021-pol2qm74 8394 26 patients patient NNS cord-015021-pol2qm74 8394 27 who who WP cord-015021-pol2qm74 8394 28 were be VBD cord-015021-pol2qm74 8394 29 not not RB cord-015021-pol2qm74 8394 30 critically critically RB cord-015021-pol2qm74 8394 31 Ill Ill NNP cord-015021-pol2qm74 8394 32 , , , cord-015021-pol2qm74 8394 33 The the DT cord-015021-pol2qm74 8394 34 resulting result VBG cord-015021-pol2qm74 8394 35 normalized normalize VBN cord-015021-pol2qm74 8394 36 seventeen seventeen CD cord-015021-pol2qm74 8394 37 variable variable JJ cord-015021-pol2qm74 8394 38 sets set NNS cord-015021-pol2qm74 8394 39 were be VBD cord-015021-pol2qm74 8394 40 then then RB cord-015021-pol2qm74 8394 41 clustered cluster VBN cord-015021-pol2qm74 8394 42 . . . cord-015021-pol2qm74 8395 1 Seven seven CD cord-015021-pol2qm74 8395 2 independent independent JJ cord-015021-pol2qm74 8395 3 data datum NNS cord-015021-pol2qm74 8395 4 groupings grouping NNS cord-015021-pol2qm74 8395 5 were be VBD cord-015021-pol2qm74 8395 6 developed develop VBN cord-015021-pol2qm74 8395 7 . . . cord-015021-pol2qm74 8396 1 The the DT cord-015021-pol2qm74 8396 2 normal normal JJ cord-015021-pol2qm74 8396 3 stress stress NN cord-015021-pol2qm74 8396 4 response response NN cord-015021-pol2qm74 8396 5 hyperdynamic hyperdynamic JJ cord-015021-pol2qm74 8396 6 state state NN cord-015021-pol2qm74 8396 7 seen see VBD cord-015021-pol2qm74 8396 8 post post NN cord-015021-pol2qm74 8396 9 - - NNP cord-015021-pol2qm74 8396 10 Trauma trauma NN cord-015021-pol2qm74 8396 11 and and CC cord-015021-pol2qm74 8396 12 in in IN cord-015021-pol2qm74 8396 13 compensated compensate VBN cord-015021-pol2qm74 8396 14 sepsis sepsis NN cord-015021-pol2qm74 8397 1 ( ( -LRB- cord-015021-pol2qm74 8397 2 A a DT cord-015021-pol2qm74 8397 3 Stets)/ Stets)/ NNP cord-015021-pol2qm74 8397 4 metabolic metabolic JJ cord-015021-pol2qm74 8397 5 insufficiency insufficiency NN cord-015021-pol2qm74 8397 6 seen see VBN cord-015021-pol2qm74 8397 7 in in IN cord-015021-pol2qm74 8397 8 septic septic JJ cord-015021-pol2qm74 8397 9 decompsnsation decompsnsation NN cord-015021-pol2qm74 8397 10 ( ( -LRB- cord-015021-pol2qm74 8397 11 B B NNP cord-015021-pol2qm74 8397 12 StSte StSte NNP cord-015021-pol2qm74 8397 13 } } -RRB- cord-015021-pol2qm74 8397 14 ; ; : cord-015021-pol2qm74 8397 15 early early JJ cord-015021-pol2qm74 8397 16 ( ( -LRB- cord-015021-pol2qm74 8397 17 C C NNP cord-015021-pol2qm74 8397 18 , , , cord-015021-pol2qm74 8397 19 ) ) -RRB- cord-015021-pol2qm74 8397 20 and and CC cord-015021-pol2qm74 8397 21 late late JJ cord-015021-pol2qm74 8397 22 ( ( -LRB- cord-015021-pol2qm74 8397 23 e2 e2 NN cord-015021-pol2qm74 8397 24 ) ) -RRB- cord-015021-pol2qm74 8397 25 respiratory respiratory JJ cord-015021-pol2qm74 8397 26 insufficiency insufficiency NN cord-015021-pol2qm74 8397 27 associated associate VBN cord-015021-pol2qm74 8397 28 with with IN cord-015021-pol2qm74 8397 29 ARDS ARDS NNP cord-015021-pol2qm74 8397 30 ; ; : cord-015021-pol2qm74 8397 31 cardlogenlc cardlogenlc NNP cord-015021-pol2qm74 8397 32 dscompensation dscompensation NNP cord-015021-pol2qm74 8397 33 ( ( -LRB- cord-015021-pol2qm74 8397 34 n n NNP cord-015021-pol2qm74 8397 35 State State NNP cord-015021-pol2qm74 8397 36 ) ) -RRB- cord-015021-pol2qm74 8397 37 ; ; : cord-015021-pol2qm74 8397 38 post post JJ cord-015021-pol2qm74 8397 39 - - JJ cord-015021-pol2qm74 8397 40 Trauma trauma JJ cord-015021-pol2qm74 8397 41 hyvolemla hyvolemla NN cord-015021-pol2qm74 8397 42 without without IN cord-015021-pol2qm74 8397 43 shock shock NN cord-015021-pol2qm74 8397 44 ( ( -LRB- cord-015021-pol2qm74 8397 45 R R NNP cord-015021-pol2qm74 8397 46 Stats Stats NNP cord-015021-pol2qm74 8397 47 ) ) -RRB- cord-015021-pol2qm74 8397 48 . . . cord-015021-pol2qm74 8398 1 The the DT cord-015021-pol2qm74 8398 2 Stats Stats NNPS cord-015021-pol2qm74 8398 3 closest close JJS cord-015021-pol2qm74 8398 4 to to IN cord-015021-pol2qm74 8398 5 a a DT cord-015021-pol2qm74 8398 6 new new JJ cord-015021-pol2qm74 8398 7 patient patient NN cord-015021-pol2qm74 8398 8 's 's POS cord-015021-pol2qm74 8398 9 values value NNS cord-015021-pol2qm74 8398 10 allows allow VBZ cord-015021-pol2qm74 8398 11 patient patient JJ cord-015021-pol2qm74 8398 12 classifi0atlon classifi0atlon NNP cord-015021-pol2qm74 8398 13 with with IN cord-015021-pol2qm74 8398 14 regard regard NN cord-015021-pol2qm74 8398 15 to to IN cord-015021-pol2qm74 8398 16 his -PRON- PRP$ cord-015021-pol2qm74 8398 17 previous previous JJ cord-015021-pol2qm74 8398 18 physiologic physiologic JJ cord-015021-pol2qm74 8398 19 state state NN cord-015021-pol2qm74 8398 20 . . . cord-015021-pol2qm74 8399 1 Classifying classify VBG cord-015021-pol2qm74 8399 2 observations observation NNS cord-015021-pol2qm74 8399 3 f f NNP cord-015021-pol2qm74 8399 4 ~ ~ NFP cord-015021-pol2qm74 8399 5 om om IN cord-015021-pol2qm74 8399 6 patients patient NNS cord-015021-pol2qm74 8399 7 who who WP cord-015021-pol2qm74 8399 8 lived live VBD cord-015021-pol2qm74 8399 9 or or CC cord-015021-pol2qm74 8399 10 died die VBD cord-015021-pol2qm74 8399 11 who who WP cord-015021-pol2qm74 8399 12 fell fall VBD cord-015021-pol2qm74 8399 13 into into IN cord-015021-pol2qm74 8399 14 these these DT cord-015021-pol2qm74 8399 15 physiologic physiologic JJ cord-015021-pol2qm74 8399 16 states state NNS cord-015021-pol2qm74 8399 17 enables enable VBZ cord-015021-pol2qm74 8399 18 a a DT cord-015021-pol2qm74 8399 19 probability probability NN cord-015021-pol2qm74 8399 20 of of IN cord-015021-pol2qm74 8399 21 death death NN cord-015021-pol2qm74 8399 22 ( ( -LRB- cord-015021-pol2qm74 8399 23 P p NN cord-015021-pol2qm74 8399 24 death death NN cord-015021-pol2qm74 8399 25 ) ) -RRB- cord-015021-pol2qm74 8399 26 to to TO cord-015021-pol2qm74 8399 27 be be VB cord-015021-pol2qm74 8399 28 obtalned obtalne VBN cord-015021-pol2qm74 8399 29 . . . cord-015021-pol2qm74 8400 1 Utilizing utilize VBG cord-015021-pol2qm74 8400 2 this this DT cord-015021-pol2qm74 8400 3 criteria criterion NNS cord-015021-pol2qm74 8400 4 for for IN cord-015021-pol2qm74 8400 5 the the DT cord-015021-pol2qm74 8400 6 staging staging NN cord-015021-pol2qm74 8400 7 of of IN cord-015021-pol2qm74 8400 8 severity severity NN cord-015021-pol2qm74 8400 9 in in IN cord-015021-pol2qm74 8400 10 44 44 CD cord-015021-pol2qm74 8400 11 recent recent JJ cord-015021-pol2qm74 8400 12 Trauma trauma NN cord-015021-pol2qm74 8400 13 patients patient NNS cord-015021-pol2qm74 8400 14 the the DT cord-015021-pol2qm74 8400 15 physiologic physiologic JJ cord-015021-pol2qm74 8400 16 States States NNPS cord-015021-pol2qm74 8400 17 accurately accurately RB cord-015021-pol2qm74 8400 18 and and CC cord-015021-pol2qm74 8400 19 significantly significantly RB cord-015021-pol2qm74 8400 20 predicted predict VBD cord-015021-pol2qm74 8400 21 the the DT cord-015021-pol2qm74 8400 22 likelihood likelihood NN cord-015021-pol2qm74 8400 23 that that IN cord-015021-pol2qm74 8400 24 the the DT cord-015021-pol2qm74 8400 25 patient patient NN cord-015021-pol2qm74 8400 26 had have VBD cord-015021-pol2qm74 8400 27 an an DT cord-015021-pol2qm74 8400 28 increased increase VBN cord-015021-pol2qm74 8400 29 circulating circulate VBG cord-015021-pol2qm74 8400 30 level level NN cord-015021-pol2qm74 8400 31 of of IN cord-015021-pol2qm74 8400 32 the the DT cord-015021-pol2qm74 8400 33 eytoklnes eytoklnes NNP cord-015021-pol2qm74 8400 34 TNF TNF NNP cord-015021-pol2qm74 8400 35 and and CC cord-015021-pol2qm74 8400 36 IL-1 IL-1 NNP cord-015021-pol2qm74 8400 37 . . . cord-015021-pol2qm74 8401 1 The the DT cord-015021-pol2qm74 8401 2 probability probability NN cord-015021-pol2qm74 8401 3 of of IN cord-015021-pol2qm74 8401 4 death death NN cord-015021-pol2qm74 8401 5 ( ( -LRB- cord-015021-pol2qm74 8401 6 P p NN cord-015021-pol2qm74 8401 7 death death NN cord-015021-pol2qm74 8401 8 ) ) -RRB- cord-015021-pol2qm74 8401 9 as as RB cord-015021-pol2qm74 8401 10 well well RB cord-015021-pol2qm74 8401 11 as as IN cord-015021-pol2qm74 8401 12 the the DT cord-015021-pol2qm74 8401 13 cytoklne cytoklne JJ cord-015021-pol2qm74 8401 14 levels level NNS cord-015021-pol2qm74 8401 15 appear appear VBP cord-015021-pol2qm74 8401 16 to to TO cord-015021-pol2qm74 8401 17 be be VB cord-015021-pol2qm74 8401 18 a a DT cord-015021-pol2qm74 8401 19 function function NN cord-015021-pol2qm74 8401 20 of of IN cord-015021-pol2qm74 8401 21 the the DT cord-015021-pol2qm74 8401 22 physiologic physiologic JJ cord-015021-pol2qm74 8401 23 B B NNP cord-015021-pol2qm74 8401 24 State State NNP cord-015021-pol2qm74 8401 25 with with IN cord-015021-pol2qm74 8401 26 the the DT cord-015021-pol2qm74 8401 27 highest high JJS cord-015021-pol2qm74 8401 28 levels level NNS cord-015021-pol2qm74 8401 29 being be VBG cord-015021-pol2qm74 8401 30 seen see VBN cord-015021-pol2qm74 8401 31 in in IN cord-015021-pol2qm74 8401 32 the the DT cord-015021-pol2qm74 8401 33 B B NNP cord-015021-pol2qm74 8401 34 State State NNP cord-015021-pol2qm74 8401 35 of of IN cord-015021-pol2qm74 8401 36 metabolic metabolic JJ cord-015021-pol2qm74 8401 37 insufficiency insufficiency NN cord-015021-pol2qm74 8401 38 and and CC cord-015021-pol2qm74 8401 39 the the DT cord-015021-pol2qm74 8401 40 C~ C~ NNP cord-015021-pol2qm74 8401 41 State State NNP cord-015021-pol2qm74 8401 42 of of IN cord-015021-pol2qm74 8401 43 oombined oombine VBN cord-015021-pol2qm74 8401 44 respiratory respiratory JJ cord-015021-pol2qm74 8401 45 and and CC cord-015021-pol2qm74 8401 46 metabolic metabolic JJ cord-015021-pol2qm74 8401 47 insqffioienoy insqffioienoy NN cord-015021-pol2qm74 8401 48 characteristic characteristic NN cord-015021-pol2qm74 8401 49 of of IN cord-015021-pol2qm74 8401 50 septlc septlc NN cord-015021-pol2qm74 8401 51 ARDS ARDS NNP cord-015021-pol2qm74 8401 52 . . . cord-015021-pol2qm74 8402 1 The the DT cord-015021-pol2qm74 8402 2 increase increase NN cord-015021-pol2qm74 8402 3 in in IN cord-015021-pol2qm74 8402 4 the the DT cord-015021-pol2qm74 8402 5 magnltude magnltude NN cord-015021-pol2qm74 8402 6 of of IN cord-015021-pol2qm74 8402 7 metabolic metabolic JJ cord-015021-pol2qm74 8402 8 abnormalities abnormality NNS cord-015021-pol2qm74 8402 9 associated associate VBN cord-015021-pol2qm74 8402 10 with with IN cord-015021-pol2qm74 8402 11 the the DT cord-015021-pol2qm74 8402 12 transition transition NN cord-015021-pol2qm74 8402 13 from from IN cord-015021-pol2qm74 8402 14 non non JJ cord-015021-pol2qm74 8402 15 - - NN cord-015021-pol2qm74 8402 16 sepsls sepsls JJ cord-015021-pol2qm74 8402 17 to to TO cord-015021-pol2qm74 8402 18 septic septic VB cord-015021-pol2qm74 8402 19 A a DT cord-015021-pol2qm74 8402 20 , , , cord-015021-pol2qm74 8402 21 septic septic JJ cord-015021-pol2qm74 8402 22 B b NN cord-015021-pol2qm74 8402 23 , , , cord-015021-pol2qm74 8402 24 or or CC cord-015021-pol2qm74 8402 25 septic septic JJ cord-015021-pol2qm74 8402 26 C c NN cord-015021-pol2qm74 8402 27 z z NNP cord-015021-pol2qm74 8402 28 States States NNP cord-015021-pol2qm74 8402 29 WaS be VBD cord-015021-pol2qm74 8402 30 associated associate VBN cord-015021-pol2qm74 8402 31 with with IN cord-015021-pol2qm74 8402 32 an an DT cord-015021-pol2qm74 8402 33 increasing increase VBG cord-015021-pol2qm74 8402 34 probability probability NN cord-015021-pol2qm74 8402 35 of of IN cord-015021-pol2qm74 8402 36 death death NN cord-015021-pol2qm74 8402 37 ( ( -LRB- cord-015021-pol2qm74 8402 38 P p NN cord-015021-pol2qm74 8402 39 denth)(mean denth)(mean NNP cord-015021-pol2qm74 8402 40 A a DT cord-015021-pol2qm74 8402 41 state state NN cord-015021-pol2qm74 8402 42 = = SYM cord-015021-pol2qm74 8402 43 .28 .28 NN cord-015021-pol2qm74 8402 44 , , , cord-015021-pol2qm74 8402 45 mean mean JJ cord-015021-pol2qm74 8402 46 B B NNP cord-015021-pol2qm74 8402 47 State state NN cord-015021-pol2qm74 8402 48 = = NFP cord-015021-pol2qm74 8403 1 .57 .57 . cord-015021-pol2qm74 8404 1 , , , cord-015021-pol2qm74 8404 2 mean mean VB cord-015021-pol2qm74 8404 3 ~ ~ NFP cord-015021-pol2qm74 8404 4 State state NN cord-015021-pol2qm74 8404 5 = = SYM cord-015021-pol2qm74 8404 6 .61 .61 CD cord-015021-pol2qm74 8404 7 ) ) -RRB- cord-015021-pol2qm74 8404 8 . . . cord-015021-pol2qm74 8405 1 The the DT cord-015021-pol2qm74 8405 2 accuraay accuraay NN cord-015021-pol2qm74 8405 3 of of IN cord-015021-pol2qm74 8405 4 this this DT cord-015021-pol2qm74 8405 5 estimate estimate NN cord-015021-pol2qm74 8405 6 was be VBD cord-015021-pol2qm74 8405 7 prospectively prospectively RB cord-015021-pol2qm74 8405 8 analyzed analyze VBN cord-015021-pol2qm74 8405 9 in in IN cord-015021-pol2qm74 8405 10 this this DT cord-015021-pol2qm74 8405 11 group group NN cord-015021-pol2qm74 8405 12 of of IN cord-015021-pol2qm74 8405 13 44 44 CD cord-015021-pol2qm74 8405 14 m m NN cord-015021-pol2qm74 8405 15 ~ ~ NFP cord-015021-pol2qm74 8405 16 Itlple Itlple NNP cord-015021-pol2qm74 8405 17 patients patient NNS cord-015021-pol2qm74 8405 18 of of IN cord-015021-pol2qm74 8405 19 whom whom WP cord-015021-pol2qm74 8405 20 72 72 CD cord-015021-pol2qm74 8405 21 % % NN cord-015021-pol2qm74 8405 22 had have VBD cord-015021-pol2qm74 8405 23 sepsis sepsis NN cord-015021-pol2qm74 8405 24 and and CC cord-015021-pol2qm74 8405 25 36 36 CD cord-015021-pol2qm74 8405 26 % % NN cord-015021-pol2qm74 8405 27 had have VBD cord-015021-pol2qm74 8405 28 ssptlo ssptlo FW cord-015021-pol2qm74 8405 29 ARDS ARDS NNP cord-015021-pol2qm74 8405 30 . . . cord-015021-pol2qm74 8406 1 The the DT cord-015021-pol2qm74 8406 2 22 22 CD cord-015021-pol2qm74 8406 3 survivors survivor NNS cord-015021-pol2qm74 8406 4 had have VBD cord-015021-pol2qm74 8406 5 a a DT cord-015021-pol2qm74 8406 6 mean mean NN cord-015021-pol2qm74 8406 7 P p NN cord-015021-pol2qm74 8406 8 death death NN cord-015021-pol2qm74 8406 9 of of IN cord-015021-pol2qm74 8406 10 0.39 0.39 CD cord-015021-pol2qm74 8406 11 and and CC cord-015021-pol2qm74 8406 12 the the DT cord-015021-pol2qm74 8406 13 22 22 CD cord-015021-pol2qm74 8406 14 deaths death NNS cord-015021-pol2qm74 8406 15 had have VBD cord-015021-pol2qm74 8406 16 a a DT cord-015021-pol2qm74 8406 17 mean mean NN cord-015021-pol2qm74 8406 18 P p NN cord-015021-pol2qm74 8406 19 death death NN cord-015021-pol2qm74 8406 20 of of IN cord-015021-pol2qm74 8406 21 0.63 0.63 CD cord-015021-pol2qm74 8406 22 . . . cord-015021-pol2qm74 8407 1 The the DT cord-015021-pol2qm74 8407 2 severity severity NN cord-015021-pol2qm74 8407 3 of of IN cord-015021-pol2qm74 8407 4 post post JJ cord-015021-pol2qm74 8407 5 - - JJ cord-015021-pol2qm74 8407 6 Trauma trauma JJ cord-015021-pol2qm74 8407 7 sepsis sepsis NN cord-015021-pol2qm74 8407 8 can can MD cord-015021-pol2qm74 8407 9 be be VB cord-015021-pol2qm74 8407 10 quantified quantify VBN cord-015021-pol2qm74 8407 11 by by IN cord-015021-pol2qm74 8407 12 probability probability NN cord-015021-pol2qm74 8407 13 analysis analysis NN cord-015021-pol2qm74 8407 14 and and CC cord-015021-pol2qm74 8407 15 stra stra NNP cord-015021-pol2qm74 8407 16 ~ ~ NFP cord-015021-pol2qm74 8407 17 Ifie~ Ifie~ VBN cord-015021-pol2qm74 8407 18 by by IN cord-015021-pol2qm74 8407 19 physiologic physiologic JJ cord-015021-pol2qm74 8407 20 State state NN cord-015021-pol2qm74 8407 21 . . . cord-015021-pol2qm74 8408 1 Serologic Serologic NNP cord-015021-pol2qm74 8408 2 tests test NNS cord-015021-pol2qm74 8408 3 have have VBP cord-015021-pol2qm74 8408 4 not not RB cord-015021-pol2qm74 8408 5 been be VBN cord-015021-pol2qm74 8408 6 extensively extensively RB cord-015021-pol2qm74 8408 7 tes'~ed tes'~e VBN cord-015021-pol2qm74 8408 8 in in IN cord-015021-pol2qm74 8408 9 surgical surgical JJ cord-015021-pol2qm74 8408 10 patients patient NNS cord-015021-pol2qm74 8408 11 but but CC cord-015021-pol2qm74 8408 12 seem seem VBP cord-015021-pol2qm74 8408 13 to to TO cord-015021-pol2qm74 8408 14 be be VB cord-015021-pol2qm74 8408 15 of of IN cord-015021-pol2qm74 8408 16 limited limited JJ cord-015021-pol2qm74 8408 17 value value NN cord-015021-pol2qm74 8408 18 . . . cord-015021-pol2qm74 8409 1 We -PRON- PRP cord-015021-pol2qm74 8409 2 use use VBP cord-015021-pol2qm74 8409 3 nystatin nystatin NNS cord-015021-pol2qm74 8409 4 as as IN cord-015021-pol2qm74 8409 5 the the DT cord-015021-pol2qm74 8409 6 main main JJ cord-015021-pol2qm74 8409 7 form form NN cord-015021-pol2qm74 8409 8 of of IN cord-015021-pol2qm74 8409 9 chemoprophyhxis chemoprophyhxis NN cord-015021-pol2qm74 8409 10 . . . cord-015021-pol2qm74 8410 1 Patients patient NNS cord-015021-pol2qm74 8410 2 " " '' cord-015021-pol2qm74 8411 1 ~'ith ~'ith NFP cord-015021-pol2qm74 8411 2 signs sign NNS cord-015021-pol2qm74 8411 3 of of IN cord-015021-pol2qm74 8411 4 infection infection NN cord-015021-pol2qm74 8411 5 who who WP cord-015021-pol2qm74 8411 6 do do VBP cord-015021-pol2qm74 8411 7 not not RB cord-015021-pol2qm74 8411 8 rapidly rapidly RB cord-015021-pol2qm74 8411 9 improve improve VB cord-015021-pol2qm74 8411 10 with with IN cord-015021-pol2qm74 8411 11 antibacterial antibacterial JJ cord-015021-pol2qm74 8411 12 therapy therapy NN cord-015021-pol2qm74 8411 13 are be VBP cord-015021-pol2qm74 8411 14 candidates candidate NNS cord-015021-pol2qm74 8411 15 for for IN cord-015021-pol2qm74 8411 16 anti anti JJ cord-015021-pol2qm74 8411 17 - - JJ cord-015021-pol2qm74 8411 18 funsal funsal JJ cord-015021-pol2qm74 8411 19 therapy therapy NN cord-015021-pol2qm74 8411 20 , , , cord-015021-pol2qm74 8411 21 Amphoteradn Amphoteradn NNP cord-015021-pol2qm74 8411 22 B B NNP cord-015021-pol2qm74 8411 23 remains remain VBZ cord-015021-pol2qm74 8411 24 the the DT cord-015021-pol2qm74 8411 25 first first JJ cord-015021-pol2qm74 8411 26 llne llne NN cord-015021-pol2qm74 8411 27 of of IN cord-015021-pol2qm74 8411 28 therapy therapy NN cord-015021-pol2qm74 8411 29 although although IN cord-015021-pol2qm74 8411 30 combination combination NN cord-015021-pol2qm74 8411 31 therapy therapy NN cord-015021-pol2qm74 8411 32 ' ' POS cord-015021-pol2qm74 8411 33 ~'ith ~'ith CD cord-015021-pol2qm74 8411 34 flueonazole flueonazole NNP cord-015021-pol2qm74 8411 35 is be VBZ cord-015021-pol2qm74 8411 36 use;l use;l NNP cord-015021-pol2qm74 8411 37 with with IN cord-015021-pol2qm74 8411 38 increasing increase VBG cord-015021-pol2qm74 8411 39 freque~;c freque~;c NNS cord-015021-pol2qm74 8411 40 ) ) -RRB- cord-015021-pol2qm74 8411 41 ' ' '' cord-015021-pol2qm74 8411 42 , , , cord-015021-pol2qm74 8411 43 The the DT cord-015021-pol2qm74 8411 44 recovery recovery NN cord-015021-pol2qm74 8411 45 of of IN cord-015021-pol2qm74 8411 46 C C NNP cord-015021-pol2qm74 8411 47 ~ ~ NFP cord-015021-pol2qm74 8411 48 dida dida NNP cord-015021-pol2qm74 8411 49 from from IN cord-015021-pol2qm74 8411 50 an an DT cord-015021-pol2qm74 8411 51 antra antra JJ cord-015021-pol2qm74 8411 52 - - HYPH cord-015021-pol2qm74 8411 53 abdominal abdominal JJ cord-015021-pol2qm74 8411 54 site site NN cord-015021-pol2qm74 8411 55 represents represent VBZ cord-015021-pol2qm74 8411 56 a a DT cord-015021-pol2qm74 8411 57 challenging challenging JJ cord-015021-pol2qm74 8411 58 problem problem NN cord-015021-pol2qm74 8411 59 , , , cord-015021-pol2qm74 8411 60 Anti Anti NNP cord-015021-pol2qm74 8411 61 ~ ~ NNP cord-015021-pol2qm74 8411 62 ngal ngal JJ cord-015021-pol2qm74 8411 63 therapy therapy NN cord-015021-pol2qm74 8411 64 in in IN cord-015021-pol2qm74 8411 65 such such JJ cord-015021-pol2qm74 8411 66 patients patient NNS cord-015021-pol2qm74 8411 67 depends depend VBZ cord-015021-pol2qm74 8411 68 on on IN cord-015021-pol2qm74 8411 69 the the DT cord-015021-pol2qm74 8411 70 underlying underlie VBG cord-015021-pol2qm74 8411 71 disease disease NN cord-015021-pol2qm74 8411 72 , , , cord-015021-pol2qm74 8411 73 the the DT cord-015021-pol2qm74 8411 74 nature nature NN cord-015021-pol2qm74 8411 75 of of IN cord-015021-pol2qm74 8411 76 the the DT cord-015021-pol2qm74 8411 77 infected infected JJ cord-015021-pol2qm74 8411 78 material material NN cord-015021-pol2qm74 8411 79 and and CC cord-015021-pol2qm74 8411 80 overall overall JJ cord-015021-pol2qm74 8411 81 patient patient JJ cord-015021-pol2qm74 8411 82 risk risk NN cord-015021-pol2qm74 8411 83 . . . cord-015021-pol2qm74 8412 1 Role role NN cord-015021-pol2qm74 8412 2 of of IN cord-015021-pol2qm74 8412 3 neural neural JJ cord-015021-pol2qm74 8412 4 stimuli stimulus NNS cord-015021-pol2qm74 8412 5 and and CC cord-015021-pol2qm74 8412 6 pain pain NN cord-015021-pol2qm74 8412 7 Principles Principles NNPS cord-015021-pol2qm74 8412 8 and and CC cord-015021-pol2qm74 8412 9 Practice practice NN cord-015021-pol2qm74 8412 10 of of IN cord-015021-pol2qm74 8412 11 Anesthesiology Anesthesiology NNP cord-015021-pol2qm74 8412 12 Effect Effect NNP cord-015021-pol2qm74 8412 13 of of IN cord-015021-pol2qm74 8412 14 combined combine VBN cord-015021-pol2qm74 8412 15 prednisolone prednisolone NN cord-015021-pol2qm74 8412 16 , , , cord-015021-pol2qm74 8412 17 epidural epidural NN cord-015021-pol2qm74 8412 18 analgesia analgesia NN cord-015021-pol2qm74 8412 19 and and CC cord-015021-pol2qm74 8412 20 indomethacin indomethacin NN cord-015021-pol2qm74 8412 21 on on IN cord-015021-pol2qm74 8412 22 the the DT cord-015021-pol2qm74 8412 23 systemic systemic JJ cord-015021-pol2qm74 8412 24 response response NN cord-015021-pol2qm74 8412 25 after after IN cord-015021-pol2qm74 8412 26 colonic colonic JJ cord-015021-pol2qm74 8412 27 surgery surgery NN cord-015021-pol2qm74 8412 28 Arginine Arginine NNP cord-015021-pol2qm74 8412 29 : : : cord-015021-pol2qm74 8412 30 Biochemistry Biochemistry NNP cord-015021-pol2qm74 8412 31 , , , cord-015021-pol2qm74 8412 32 physiology physiology NN cord-015021-pol2qm74 8412 33 and and CC cord-015021-pol2qm74 8412 34 therapeutic therapeutic JJ cord-015021-pol2qm74 8412 35 irnplications irnplication NNS cord-015021-pol2qm74 8413 1 Immunosfimulatory immunosfimulatory JJ cord-015021-pol2qm74 8413 2 effects effect NNS cord-015021-pol2qm74 8413 3 of of IN cord-015021-pol2qm74 8413 4 arginine arginine NN cord-015021-pol2qm74 8413 5 in in IN cord-015021-pol2qm74 8413 6 normal normal JJ cord-015021-pol2qm74 8413 7 and and CC cord-015021-pol2qm74 8413 8 injured injured JJ cord-015021-pol2qm74 8413 9 rats rat NNS cord-015021-pol2qm74 8414 1 Arginine arginine NN cord-015021-pol2qm74 8414 2 stimulates stimulate VBZ cord-015021-pol2qm74 8414 3 lymphocyte lymphocyte NN cord-015021-pol2qm74 8414 4 immune immune NN cord-015021-pol2qm74 8414 5 response response NN cord-015021-pol2qm74 8414 6 in in IN cord-015021-pol2qm74 8414 7 heahhy heahhy NNP cord-015021-pol2qm74 8414 8 humans human NNS cord-015021-pol2qm74 8414 9 Rote Rote NNP cord-015021-pol2qm74 8414 10 of of IN cord-015021-pol2qm74 8414 11 arginine arginine NN cord-015021-pol2qm74 8414 12 in in IN cord-015021-pol2qm74 8414 13 trauma trauma NN cord-015021-pol2qm74 8414 14 , , , cord-015021-pol2qm74 8414 15 sepsis sepsis NN cord-015021-pol2qm74 8414 16 and and CC cord-015021-pol2qm74 8414 17 immunity immunity NN cord-015021-pol2qm74 8415 1 Arginine arginine NN cord-015021-pol2qm74 8415 2 enhances enhance VBZ cord-015021-pol2qm74 8415 3 wound wind VBN cord-015021-pol2qm74 8415 4 healing healing NN cord-015021-pol2qm74 8415 5 in in IN cord-015021-pol2qm74 8415 6 humans human NNS cord-015021-pol2qm74 8415 7 IF if IN cord-015021-pol2qm74 8415 8 LaBrecque LaBrecque NNP cord-015021-pol2qm74 8415 9 t t NN cord-015021-pol2qm74 8415 10 , , , cord-015021-pol2qm74 8415 11 GV GV NNP cord-015021-pol2qm74 8415 12 Campion Campion NNP cord-015021-pol2qm74 8415 13 t t NN cord-015021-pol2qm74 8415 14 , , , cord-015021-pol2qm74 8415 15 and and CC cord-015021-pol2qm74 8415 16 the the DT cord-015021-pol2qm74 8415 17 rhlL rhlL NNP cord-015021-pol2qm74 8415 18 - - HYPH cord-015021-pol2qm74 8415 19 lra lra NNP cord-015021-pol2qm74 8415 20 Phase Phase NNP cord-015021-pol2qm74 8415 21 I//Sepsis I//Sepsis NNP cord-015021-pol2qm74 8415 22 Syndrome Syndrome NNP cord-015021-pol2qm74 8415 23 Study Study NNP cord-015021-pol2qm74 8415 24 Group Group NNP cord-015021-pol2qm74 8416 1 The the DT cord-015021-pol2qm74 8416 2 Cleveland Cleveland NNP cord-015021-pol2qm74 8416 3 Clinic Clinic NNP cord-015021-pol2qm74 8416 4 Foundation Foundation NNP cord-015021-pol2qm74 8417 1 A a DT cord-015021-pol2qm74 8417 2 murine murine JJ cord-015021-pol2qm74 8417 3 - - HYPH cord-015021-pol2qm74 8417 4 anti anti JJ cord-015021-pol2qm74 8417 5 - - JJ cord-015021-pol2qm74 8417 6 human human JJ cord-015021-pol2qm74 8417 7 TNF TNF NNP cord-015021-pol2qm74 8417 8 - - HYPH cord-015021-pol2qm74 8417 9 monoclonal monoclonal JJ cord-015021-pol2qm74 8417 10 antibody antibody NN cord-015021-pol2qm74 8417 11 known know VBN cord-015021-pol2qm74 8417 12 as as IN cord-015021-pol2qm74 8417 13 CB6 CB6 NNP cord-015021-pol2qm74 8417 14 was be VBD cord-015021-pol2qm74 8417 15 the the DT cord-015021-pol2qm74 8417 16 first first JJ cord-015021-pol2qm74 8417 17 ANTI ANTI NNP cord-015021-pol2qm74 8417 18 - - HYPH cord-015021-pol2qm74 8417 19 tnf tnf NNP cord-015021-pol2qm74 8417 20 MaB mab NN cord-015021-pol2qm74 8417 21 which which WDT cord-015021-pol2qm74 8417 22 was be VBD cord-015021-pol2qm74 8417 23 studied study VBN cord-015021-pol2qm74 8417 24 in in IN cord-015021-pol2qm74 8417 25 a a DT cord-015021-pol2qm74 8417 26 phase phase NN cord-015021-pol2qm74 8417 27 II ii CD cord-015021-pol2qm74 8417 28 multinational multinational JJ cord-015021-pol2qm74 8417 29 trial trial NN cord-015021-pol2qm74 8417 30 in in IN cord-015021-pol2qm74 8417 31 the the DT cord-015021-pol2qm74 8417 32 treatment treatment NN cord-015021-pol2qm74 8417 33 of of IN cord-015021-pol2qm74 8417 34 patients patient NNS cord-015021-pol2qm74 8417 35 with with IN cord-015021-pol2qm74 8417 36 severe severe JJ cord-015021-pol2qm74 8417 37 sepsis sepsis NN cord-015021-pol2qm74 8417 38 . . . cord-015021-pol2qm74 8418 1 This this DT cord-015021-pol2qm74 8418 2 was be VBD cord-015021-pol2qm74 8418 3 an an DT cord-015021-pol2qm74 8418 4 open open JJ cord-015021-pol2qm74 8418 5 - - HYPH cord-015021-pol2qm74 8418 6 label label NN cord-015021-pol2qm74 8418 7 , , , cord-015021-pol2qm74 8418 8 dose dose NN cord-015021-pol2qm74 8418 9 - - HYPH cord-015021-pol2qm74 8418 10 escalation escalation NN cord-015021-pol2qm74 8418 11 trial trial NN cord-015021-pol2qm74 8418 12 consisting consist VBG cord-015021-pol2qm74 8418 13 of of IN cord-015021-pol2qm74 8418 14 80 80 CD cord-015021-pol2qm74 8418 15 patients patient NNS cord-015021-pol2qm74 8418 16 who who WP cord-015021-pol2qm74 8418 17 were be VBD cord-015021-pol2qm74 8418 18 enrolled enrol VBN cord-015021-pol2qm74 8418 19 into into IN cord-015021-pol2qm74 8418 20 one one CD cord-015021-pol2qm74 8418 21 of of IN cord-015021-pol2qm74 8418 22 four four CD cord-015021-pol2qm74 8418 23 treatment treatment NN cord-015021-pol2qm74 8418 24 groups group NNS cord-015021-pol2qm74 8418 25 : : : cord-015021-pol2qm74 8418 26 ( ( -LRB- cord-015021-pol2qm74 8418 27 1 1 LS cord-015021-pol2qm74 8418 28 ) ) -RRB- cord-015021-pol2qm74 8418 29 0.1 0.1 CD cord-015021-pol2qm74 8418 30 mg mg NNP cord-015021-pol2qm74 8418 31 / / SYM cord-015021-pol2qm74 8418 32 kg kg NNS cord-015021-pol2qm74 8418 33 of of IN cord-015021-pol2qm74 8418 34 anti anti JJ cord-015021-pol2qm74 8418 35 - - JJ cord-015021-pol2qm74 8418 36 TNF TNF NNP cord-015021-pol2qm74 8419 1 mAb mAb NNS cord-015021-pol2qm74 8419 2 , , , cord-015021-pol2qm74 8419 3 ( ( -LRB- cord-015021-pol2qm74 8419 4 2 2 LS cord-015021-pol2qm74 8419 5 ) ) -RRB- cord-015021-pol2qm74 8419 6 1.0 1.0 CD cord-015021-pol2qm74 8419 7 mg mg NN cord-015021-pol2qm74 8419 8 / / SYM cord-015021-pol2qm74 8419 9 kg kg NNP cord-015021-pol2qm74 8419 10 , , , cord-015021-pol2qm74 8419 11 ( ( -LRB- cord-015021-pol2qm74 8419 12 3 3 CD cord-015021-pol2qm74 8419 13 ) ) -RRB- cord-015021-pol2qm74 8419 14 10 10 CD cord-015021-pol2qm74 8419 15 mg mg NNP cord-015021-pol2qm74 8419 16 / / SYM cord-015021-pol2qm74 8419 17 kg kg NNS cord-015021-pol2qm74 8419 18 or or CC cord-015021-pol2qm74 8419 19 ( ( -LRB- cord-015021-pol2qm74 8419 20 4 4 CD cord-015021-pol2qm74 8419 21 ) ) -RRB- cord-015021-pol2qm74 8419 22 1.0 1.0 CD cord-015021-pol2qm74 8419 23 mg mg NN cord-015021-pol2qm74 8419 24 / / SYM cord-015021-pol2qm74 8419 25 kg kg NNP cord-015021-pol2qm74 8419 26 at at IN cord-015021-pol2qm74 8419 27 study study NN cord-015021-pol2qm74 8419 28 entry entry NN cord-015021-pol2qm74 8419 29 and and CC cord-015021-pol2qm74 8419 30 the the DT cord-015021-pol2qm74 8419 31 second second JJ cord-015021-pol2qm74 8419 32 dose dose NN cord-015021-pol2qm74 8419 33 24 24 CD cord-015021-pol2qm74 8419 34 hours hour NNS cord-015021-pol2qm74 8419 35 later later RB cord-015021-pol2qm74 8419 36 . . . cord-015021-pol2qm74 8420 1 The the DT cord-015021-pol2qm74 8420 2 small small JJ cord-015021-pol2qm74 8420 3 sample sample NN cord-015021-pol2qm74 8420 4 size size NN cord-015021-pol2qm74 8420 5 in in IN cord-015021-pol2qm74 8420 6 each each DT cord-015021-pol2qm74 8420 7 group group NN cord-015021-pol2qm74 8420 8 ( ( -LRB- cord-015021-pol2qm74 8420 9 n=20 n=20 NNP cord-015021-pol2qm74 8420 10 ) ) -RRB- cord-015021-pol2qm74 8420 11 precludes preclude VBZ cord-015021-pol2qm74 8420 12 detailed detailed JJ cord-015021-pol2qm74 8420 13 statistical statistical JJ cord-015021-pol2qm74 8420 14 inference inference NN cord-015021-pol2qm74 8420 15 in in IN cord-015021-pol2qm74 8420 16 this this DT cord-015021-pol2qm74 8420 17 study study NN cord-015021-pol2qm74 8420 18 . . . cord-015021-pol2qm74 8421 1 Nonetheless nonetheless RB cord-015021-pol2qm74 8421 2 , , , cord-015021-pol2qm74 8421 3 a a DT cord-015021-pol2qm74 8421 4 considerable considerable JJ cord-015021-pol2qm74 8421 5 amount amount NN cord-015021-pol2qm74 8421 6 of of IN cord-015021-pol2qm74 8421 7 useful useful JJ cord-015021-pol2qm74 8421 8 information information NN cord-015021-pol2qm74 8421 9 was be VBD cord-015021-pol2qm74 8421 10 obtained obtain VBN cord-015021-pol2qm74 8421 11 from from IN cord-015021-pol2qm74 8421 12 this this DT cord-015021-pol2qm74 8421 13 investigation investigation NN cord-015021-pol2qm74 8421 14 . . . cord-015021-pol2qm74 8422 1 irst irst RB cord-015021-pol2qm74 8422 2 , , , cord-015021-pol2qm74 8422 3 this this DT cord-015021-pol2qm74 8422 4 study study NN cord-015021-pol2qm74 8422 5 demonstrated demonstrate VBD cord-015021-pol2qm74 8422 6 the the DT cord-015021-pol2qm74 8422 7 clinical clinical JJ cord-015021-pol2qm74 8422 8 feasibility feasibility NN cord-015021-pol2qm74 8422 9 of of IN cord-015021-pol2qm74 8422 10 specific specific JJ cord-015021-pol2qm74 8422 11 anticytoldne anticytoldne NNP cord-015021-pol2qm74 8422 12 therapy therapy NN cord-015021-pol2qm74 8422 13 in in IN cord-015021-pol2qm74 8422 14 septic septic JJ cord-015021-pol2qm74 8422 15 patients patient NNS cord-015021-pol2qm74 8422 16 . . . cord-015021-pol2qm74 8423 1 Second second RB cord-015021-pol2qm74 8423 2 , , , cord-015021-pol2qm74 8423 3 the the DT cord-015021-pol2qm74 8423 4 measurement measurement NN cord-015021-pol2qm74 8423 5 systemic systemic JJ cord-015021-pol2qm74 8423 6 levels level NNS cord-015021-pol2qm74 8423 7 of of IN cord-015021-pol2qm74 8423 8 TNF TNF NNP cord-015021-pol2qm74 8423 9 proved prove VBD cord-015021-pol2qm74 8423 10 to to TO cord-015021-pol2qm74 8423 11 be be VB cord-015021-pol2qm74 8423 12 an an DT cord-015021-pol2qm74 8423 13 elusive elusive JJ cord-015021-pol2qm74 8423 14 target target NN cord-015021-pol2qm74 8423 15 ; ; : cord-015021-pol2qm74 8423 16 Interleukin-6 Interleukin-6 NNP cord-015021-pol2qm74 8423 17 may may MD cord-015021-pol2qm74 8423 18 prove prove VB cord-015021-pol2qm74 8423 19 to to TO cord-015021-pol2qm74 8423 20 be be VB cord-015021-pol2qm74 8423 21 a a DT cord-015021-pol2qm74 8423 22 more more RBR cord-015021-pol2qm74 8423 23 useful useful JJ cord-015021-pol2qm74 8423 24 indicator indicator NN cord-015021-pol2qm74 8423 25 of of IN cord-015021-pol2qm74 8423 26 cytokine cytokine NN cord-015021-pol2qm74 8423 27 activation activation NN cord-015021-pol2qm74 8423 28 . . . cord-015021-pol2qm74 8424 1 Third third JJ cord-015021-pol2qm74 8424 2 , , , cord-015021-pol2qm74 8424 3 immunologic immunologic JJ cord-015021-pol2qm74 8424 4 reactions reaction NNS cord-015021-pol2qm74 8424 5 including include VBG cord-015021-pol2qm74 8424 6 TNF tnf NN cord-015021-pol2qm74 8424 7 : : : cord-015021-pol2qm74 8424 8 anti anti JJ cord-015021-pol2qm74 8424 9 - - JJ cord-015021-pol2qm74 8424 10 TNF tnf JJ cord-015021-pol2qm74 8424 11 mAb mab NN cord-015021-pol2qm74 8424 12 immune immune JJ cord-015021-pol2qm74 8424 13 complexes complex NNS cord-015021-pol2qm74 8424 14 and and CC cord-015021-pol2qm74 8424 15 human human JJ cord-015021-pol2qm74 8424 16 anti anti JJ cord-015021-pol2qm74 8424 17 - - JJ cord-015021-pol2qm74 8424 18 routine routine JJ cord-015021-pol2qm74 8424 19 antibodies antibody NNS cord-015021-pol2qm74 8424 20 were be VBD cord-015021-pol2qm74 8424 21 frequently frequently RB cord-015021-pol2qm74 8424 22 found find VBN cord-015021-pol2qm74 8424 23 in in IN cord-015021-pol2qm74 8424 24 these these DT cord-015021-pol2qm74 8424 25 patients patient NNS cord-015021-pol2qm74 8424 26 . . . cord-015021-pol2qm74 8425 1 Despite despite IN cord-015021-pol2qm74 8425 2 their -PRON- PRP$ cord-015021-pol2qm74 8425 3 apparent apparent JJ cord-015021-pol2qm74 8425 4 lack lack NN cord-015021-pol2qm74 8425 5 of of IN cord-015021-pol2qm74 8425 6 overt overt JJ cord-015021-pol2qm74 8425 7 toxicity toxicity NN cord-015021-pol2qm74 8425 8 in in IN cord-015021-pol2qm74 8425 9 this this DT cord-015021-pol2qm74 8425 10 study study NN cord-015021-pol2qm74 8425 11 , , , cord-015021-pol2qm74 8425 12 these these DT cord-015021-pol2qm74 8425 13 immunologic immunologic JJ cord-015021-pol2qm74 8425 14 reactions reaction NNS cord-015021-pol2qm74 8425 15 may may MD cord-015021-pol2qm74 8425 16 complicate complicate VB cord-015021-pol2qm74 8425 17 this this DT cord-015021-pol2qm74 8425 18 form form NN cord-015021-pol2qm74 8425 19 of of IN cord-015021-pol2qm74 8425 20 anticytokine anticytokine JJ cord-015021-pol2qm74 8425 21 therapy therapy NN cord-015021-pol2qm74 8425 22 . . . cord-015021-pol2qm74 8426 1 Additionally additionally RB cord-015021-pol2qm74 8426 2 , , , cord-015021-pol2qm74 8426 3 the the DT cord-015021-pol2qm74 8426 4 potential potential JJ cord-015021-pol2qm74 8426 5 benefits benefit NNS cord-015021-pol2qm74 8426 6 of of IN cord-015021-pol2qm74 8426 7 anti anti JJ cord-015021-pol2qm74 8426 8 - - JJ cord-015021-pol2qm74 8426 9 TNF tnf JJ cord-015021-pol2qm74 8426 10 mAb mab NN cord-015021-pol2qm74 8426 11 therapy therapy NN cord-015021-pol2qm74 8426 12 occur occur VBP cord-015021-pol2qm74 8426 13 within within IN cord-015021-pol2qm74 8426 14 the the DT cord-015021-pol2qm74 8426 15 first first JJ cord-015021-pol2qm74 8426 16 48 48 CD cord-015021-pol2qm74 8426 17 hours hour NNS cord-015021-pol2qm74 8426 18 of of IN cord-015021-pol2qm74 8426 19 therapeutic therapeutic JJ cord-015021-pol2qm74 8426 20 administration administration NN cord-015021-pol2qm74 8426 21 in in IN cord-015021-pol2qm74 8426 22 these these DT cord-015021-pol2qm74 8426 23 septic septic JJ cord-015021-pol2qm74 8426 24 patients patient NNS cord-015021-pol2qm74 8426 25 . . . cord-015021-pol2qm74 8427 1 Infecting infect VBG cord-015021-pol2qm74 8427 2 organisms organism NNS cord-015021-pol2qm74 8427 3 differ differ VBP cord-015021-pol2qm74 8427 4 in in IN cord-015021-pol2qm74 8427 5 their -PRON- PRP$ cord-015021-pol2qm74 8427 6 potential potential NN cord-015021-pol2qm74 8427 7 to to TO cord-015021-pol2qm74 8427 8 induce induce VB cord-015021-pol2qm74 8427 9 TNF TNF NNP cord-015021-pol2qm74 8427 10 in in IN cord-015021-pol2qm74 8427 11 vitro vitro FW cord-015021-pol2qm74 8427 12 and and CC cord-015021-pol2qm74 8427 13 these these DT cord-015021-pol2qm74 8427 14 differences difference NNS cord-015021-pol2qm74 8427 15 correlate correlate VBP cord-015021-pol2qm74 8427 16 with with IN cord-015021-pol2qm74 8427 17 circulating circulate VBG cord-015021-pol2qm74 8427 18 TNF TNF NNP cord-015021-pol2qm74 8427 19 levels level NNS cord-015021-pol2qm74 8427 20 observed observe VBN cord-015021-pol2qm74 8427 21 in in IN cord-015021-pol2qm74 8427 22 septic septic JJ cord-015021-pol2qm74 8427 23 patients patient NNS cord-015021-pol2qm74 8427 24 . . . cord-015021-pol2qm74 8428 1 Rapid rapid JJ cord-015021-pol2qm74 8428 2 methods method NNS cord-015021-pol2qm74 8428 3 to to TO cord-015021-pol2qm74 8428 4 define define VB cord-015021-pol2qm74 8428 5 those those DT cord-015021-pol2qm74 8428 6 patients patient NNS cord-015021-pol2qm74 8428 7 most most RBS cord-015021-pol2qm74 8428 8 likely likely JJ cord-015021-pol2qm74 8428 9 to to TO cord-015021-pol2qm74 8428 10 respond respond VB cord-015021-pol2qm74 8428 11 to to IN cord-015021-pol2qm74 8428 12 anticytokine anticytokine JJ cord-015021-pol2qm74 8428 13 therapy therapy NN cord-015021-pol2qm74 8428 14 are be VBP cord-015021-pol2qm74 8428 15 needed need VBN cord-015021-pol2qm74 8428 16 to to TO cord-015021-pol2qm74 8428 17 determine determine VB cord-015021-pol2qm74 8428 18 the the DT cord-015021-pol2qm74 8428 19 ultimate ultimate JJ cord-015021-pol2qm74 8428 20 therapeutic therapeutic JJ cord-015021-pol2qm74 8428 21 potential potential NN cord-015021-pol2qm74 8428 22 of of IN cord-015021-pol2qm74 8428 23 these these DT cord-015021-pol2qm74 8428 24 agents agent NNS cord-015021-pol2qm74 8428 25 in in IN cord-015021-pol2qm74 8428 26 clinical clinical JJ cord-015021-pol2qm74 8428 27 medicine medicine NN cord-015021-pol2qm74 8428 28 . . . cord-015021-pol2qm74 8429 1 Wherry Wherry NNP cord-015021-pol2qm74 8429 2 , , , cord-015021-pol2qm74 8429 3 J. J. NNP cord-015021-pol2qm74 8429 4 , , , cord-015021-pol2qm74 8429 5 Abraham Abraham NNP cord-015021-pol2qm74 8429 6 E. E. NNP cord-015021-pol2qm74 8429 7 , , , cord-015021-pol2qm74 8429 8 Wunderink Wunderink NNP cord-015021-pol2qm74 8429 9 R. R. NNP cord-015021-pol2qm74 8429 10 , , , cord-015021-pol2qm74 8429 11 Silverman Silverman NNP cord-015021-pol2qm74 8429 12 H. H. NNP cord-015021-pol2qm74 8429 13 , , , cord-015021-pol2qm74 8429 14 Perl Perl NNP cord-015021-pol2qm74 8429 15 T. T. NNP cord-015021-pol2qm74 8429 16 , , , cord-015021-pol2qm74 8429 17 Nasraway Nasraway NNP cord-015021-pol2qm74 8429 18 S. S. NNP cord-015021-pol2qm74 8429 19 , , , cord-015021-pol2qm74 8429 20 Levy Levy NNP cord-015021-pol2qm74 8429 21 H. H. NNP cord-015021-pol2qm74 8429 22 , , , cord-015021-pol2qm74 8429 23 Bone Bone NNP cord-015021-pol2qm74 8429 24 R. R. NNP cord-015021-pol2qm74 8429 25 , , , cord-015021-pol2qm74 8429 26 Wenzel Wenzel NNP cord-015021-pol2qm74 8429 27 R. R. NNP cord-015021-pol2qm74 8429 28 , , , cord-015021-pol2qm74 8429 29 Balk Balk NNP cord-015021-pol2qm74 8429 30 R. R. NNP cord-015021-pol2qm74 8429 31 , , , cord-015021-pol2qm74 8429 32 Allred Allred NNP cord-015021-pol2qm74 8429 33 R. R. NNP cord-015021-pol2qm74 8429 34 , , , cord-015021-pol2qm74 8429 35 Pennington Pennington NNP cord-015021-pol2qm74 8429 36 J. J. NNP cord-015021-pol2qm74 8429 37 and and CC cord-015021-pol2qm74 8429 38 the the DT cord-015021-pol2qm74 8429 39 TNFa TNFa NNS cord-015021-pol2qm74 8429 40 MAb MAb NNS cord-015021-pol2qm74 8429 41 Sepsis Sepsis NNP cord-015021-pol2qm74 8429 42 Study Study NNP cord-015021-pol2qm74 8429 43 Group Group NNP cord-015021-pol2qm74 8429 44 . . . cord-015021-pol2qm74 8430 1 TNFa TNFa NNP cord-015021-pol2qm74 8430 2 MAb MAb NNS cord-015021-pol2qm74 8430 3 ( ( -LRB- cord-015021-pol2qm74 8430 4 Bay Bay NNP cord-015021-pol2qm74 8430 5 x1351 x1351 NNP cord-015021-pol2qm74 8430 6 ) ) -RRB- cord-015021-pol2qm74 8430 7 is be VBZ cord-015021-pol2qm74 8430 8 a a DT cord-015021-pol2qm74 8430 9 murine murine JJ cord-015021-pol2qm74 8430 10 monoclonal monoclonal JJ cord-015021-pol2qm74 8430 11 antibody antibody NN cord-015021-pol2qm74 8430 12 raised raise VBN cord-015021-pol2qm74 8430 13 against against IN cord-015021-pol2qm74 8430 14 human human JJ cord-015021-pol2qm74 8430 15 tumor tumor NN cord-015021-pol2qm74 8430 16 necrosis necrosis NN cord-015021-pol2qm74 8430 17 factor factor NN cord-015021-pol2qm74 8430 18 . . . cord-015021-pol2qm74 8431 1 TNF~ tnf~ LS cord-015021-pol2qm74 8431 2 MAb MAb NNS cord-015021-pol2qm74 8431 3 has have VBZ cord-015021-pol2qm74 8431 4 been be VBN cord-015021-pol2qm74 8431 5 shown show VBN cord-015021-pol2qm74 8431 6 to to TO cord-015021-pol2qm74 8431 7 reduce reduce VB cord-015021-pol2qm74 8431 8 morbidity morbidity NN cord-015021-pol2qm74 8431 9 and and CC cord-015021-pol2qm74 8431 10 mortality mortality NN cord-015021-pol2qm74 8431 11 in in IN cord-015021-pol2qm74 8431 12 animal animal NN cord-015021-pol2qm74 8431 13 models model NNS cord-015021-pol2qm74 8431 14 of of IN cord-015021-pol2qm74 8431 15 septic septic JJ cord-015021-pol2qm74 8431 16 shock shock NN cord-015021-pol2qm74 8431 17 and and CC cord-015021-pol2qm74 8431 18 has have VBZ cord-015021-pol2qm74 8431 19 been be VBN cord-015021-pol2qm74 8431 20 safely safely RB cord-015021-pol2qm74 8431 21 administered administer VBN cord-015021-pol2qm74 8431 22 to to TO cord-015021-pol2qm74 8431 23 septic septic JJ cord-015021-pol2qm74 8431 24 and and CC cord-015021-pol2qm74 8431 25 non non JJ cord-015021-pol2qm74 8431 26 septic septic JJ cord-015021-pol2qm74 8431 27 patients patient NNS cord-015021-pol2qm74 8431 28 . . . cord-015021-pol2qm74 8432 1 To to TO cord-015021-pol2qm74 8432 2 evaluate evaluate VB cord-015021-pol2qm74 8432 3 the the DT cord-015021-pol2qm74 8432 4 efficacy efficacy NN cord-015021-pol2qm74 8432 5 and and CC cord-015021-pol2qm74 8432 6 safety safety NN cord-015021-pol2qm74 8432 7 of of IN cord-015021-pol2qm74 8432 8 TNF~ tnf~ CD cord-015021-pol2qm74 8432 9 MAb MAb NNS cord-015021-pol2qm74 8432 10 in in IN cord-015021-pol2qm74 8432 11 patients patient NNS cord-015021-pol2qm74 8432 12 with with IN cord-015021-pol2qm74 8432 13 sepsis sepsis NN cord-015021-pol2qm74 8432 14 syndrome syndrome NN cord-015021-pol2qm74 8432 15 , , , cord-015021-pol2qm74 8432 16 a a DT cord-015021-pol2qm74 8432 17 prospective prospective JJ cord-015021-pol2qm74 8432 18 , , , cord-015021-pol2qm74 8432 19 multicentered multicentered JJ cord-015021-pol2qm74 8432 20 , , , cord-015021-pol2qm74 8432 21 double double JJ cord-015021-pol2qm74 8432 22 - - HYPH cord-015021-pol2qm74 8432 23 blind blind JJ cord-015021-pol2qm74 8432 24 , , , cord-015021-pol2qm74 8432 25 placebo placebo NN cord-015021-pol2qm74 8432 26 - - HYPH cord-015021-pol2qm74 8432 27 controlled control VBN cord-015021-pol2qm74 8432 28 trial trial NN cord-015021-pol2qm74 8432 29 was be VBD cord-015021-pol2qm74 8432 30 conducted conduct VBN cord-015021-pol2qm74 8432 31 in in IN cord-015021-pol2qm74 8432 32 31 31 CD cord-015021-pol2qm74 8432 33 hospitals hospital NNS cord-015021-pol2qm74 8432 34 in in IN cord-015021-pol2qm74 8432 35 North North NNP cord-015021-pol2qm74 8432 36 America America NNP cord-015021-pol2qm74 8432 37 . . . cord-015021-pol2qm74 8433 1 Patients patient NNS cord-015021-pol2qm74 8433 2 were be VBD cord-015021-pol2qm74 8433 3 prospectively prospectively RB cord-015021-pol2qm74 8433 4 stratified stratify VBN cord-015021-pol2qm74 8433 5 into into IN cord-015021-pol2qm74 8433 6 shock shock NN cord-015021-pol2qm74 8433 7 or or CC cord-015021-pol2qm74 8433 8 nonshock nonshock NN cord-015021-pol2qm74 8433 9 groups group NNS cord-015021-pol2qm74 8433 10 and and CC cord-015021-pol2qm74 8433 11 then then RB cord-015021-pol2qm74 8433 12 randomized randomize VBD cord-015021-pol2qm74 8433 13 to to TO cord-015021-pol2qm74 8433 14 receive receive VB cord-015021-pol2qm74 8433 15 a a DT cord-015021-pol2qm74 8433 16 single single JJ cord-015021-pol2qm74 8433 17 intravenous intravenous JJ cord-015021-pol2qm74 8433 18 infusion infusion NN cord-015021-pol2qm74 8433 19 either either DT cord-015021-pol2qm74 8433 20 of of IN cord-015021-pol2qm74 8433 21 15 15 CD cord-015021-pol2qm74 8433 22 mg mg NNP cord-015021-pol2qm74 8433 23 / / SYM cord-015021-pol2qm74 8433 24 kg kg NNP cord-015021-pol2qm74 8434 1 TNF~ tnf~ LS cord-015021-pol2qm74 8434 2 MAb MAb NNS cord-015021-pol2qm74 8434 3 , , , cord-015021-pol2qm74 8434 4 7.5 7.5 CD cord-015021-pol2qm74 8434 5 mg mg NN cord-015021-pol2qm74 8434 6 / / SYM cord-015021-pol2qm74 8434 7 kg kg NNP cord-015021-pol2qm74 8435 1 TNF~ tnf~ LS cord-015021-pol2qm74 8435 2 MAb MAb NNS cord-015021-pol2qm74 8435 3 or or CC cord-015021-pol2qm74 8435 4 placebo placebo NN cord-015021-pol2qm74 8435 5 ( ( -LRB- cord-015021-pol2qm74 8435 6 0.25 0.25 CD cord-015021-pol2qm74 8435 7 % % NN cord-015021-pol2qm74 8435 8 human human JJ cord-015021-pol2qm74 8435 9 albumin).Patients albumin).patient NNS cord-015021-pol2qm74 8435 10 received receive VBD cord-015021-pol2qm74 8435 11 standard standard JJ cord-015021-pol2qm74 8435 12 aggressive aggressive JJ cord-015021-pol2qm74 8435 13 medical medical JJ cord-015021-pol2qm74 8435 14 / / SYM cord-015021-pol2qm74 8435 15 surgical surgical JJ cord-015021-pol2qm74 8435 16 care care NN cord-015021-pol2qm74 8435 17 during during IN cord-015021-pol2qm74 8435 18 the the DT cord-015021-pol2qm74 8435 19 28 28 CD cord-015021-pol2qm74 8435 20 day day NN cord-015021-pol2qm74 8435 21 post post NN cord-015021-pol2qm74 8435 22 dosing dosing NN cord-015021-pol2qm74 8435 23 period period NN cord-015021-pol2qm74 8435 24 . . . cord-015021-pol2qm74 8436 1 The the DT cord-015021-pol2qm74 8436 2 three three CD cord-015021-pol2qm74 8436 3 treatment treatment NN cord-015021-pol2qm74 8436 4 arms arm NNS cord-015021-pol2qm74 8436 5 were be VBD cord-015021-pol2qm74 8436 6 well well RB cord-015021-pol2qm74 8436 7 balanced balanced JJ cord-015021-pol2qm74 8436 8 with with IN cord-015021-pol2qm74 8436 9 respect respect NN cord-015021-pol2qm74 8436 10 to to IN cord-015021-pol2qm74 8436 11 demographics demographic NNS cord-015021-pol2qm74 8436 12 , , , cord-015021-pol2qm74 8436 13 APACHE APACHE NNP cord-015021-pol2qm74 8436 14 II II NNP cord-015021-pol2qm74 8436 15 score score NN cord-015021-pol2qm74 8436 16 and and CC cord-015021-pol2qm74 8436 17 other other JJ cord-015021-pol2qm74 8436 18 parameters parameter NNS cord-015021-pol2qm74 8436 19 . . . cord-015021-pol2qm74 8437 1 For for IN cord-015021-pol2qm74 8437 2 all all DT cord-015021-pol2qm74 8437 3 infused infuse VBN cord-015021-pol2qm74 8437 4 sepsis sepsis NN cord-015021-pol2qm74 8437 5 syndrome syndrome NN cord-015021-pol2qm74 8437 6 patients patient NNS cord-015021-pol2qm74 8437 7 , , , cord-015021-pol2qm74 8437 8 those those DT cord-015021-pol2qm74 8437 9 who who WP cord-015021-pol2qm74 8437 10 received receive VBD cord-015021-pol2qm74 8437 11 TNF~ tnf~ CD cord-015021-pol2qm74 8437 12 MAb MAb NNS cord-015021-pol2qm74 8437 13 had have VBD cord-015021-pol2qm74 8437 14 slightly slightly RB cord-015021-pol2qm74 8437 15 reduced reduce VBN cord-015021-pol2qm74 8437 16 28 28 CD cord-015021-pol2qm74 8437 17 day day NN cord-015021-pol2qm74 8437 18 all all DT cord-015021-pol2qm74 8437 19 cause cause VBP cord-015021-pol2qm74 8437 20 mortality mortality NN cord-015021-pol2qm74 8437 21 compared compare VBN cord-015021-pol2qm74 8437 22 to to IN cord-015021-pol2qm74 8437 23 placebo placebo NN cord-015021-pol2qm74 8437 24 . . . cord-015021-pol2qm74 8438 1 Among among IN cord-015021-pol2qm74 8438 2 shock shock NN cord-015021-pol2qm74 8438 3 patients patient NNS cord-015021-pol2qm74 8438 4 there there EX cord-015021-pol2qm74 8438 5 was be VBD cord-015021-pol2qm74 8438 6 a a DT cord-015021-pol2qm74 8438 7 more more RBR cord-015021-pol2qm74 8438 8 pronounced pronounced JJ cord-015021-pol2qm74 8438 9 trend trend NN cord-015021-pol2qm74 8438 10 towards towards IN cord-015021-pol2qm74 8438 11 efficacy efficacy NN cord-015021-pol2qm74 8438 12 at at IN cord-015021-pol2qm74 8438 13 day day NN cord-015021-pol2qm74 8438 14 28 28 CD cord-015021-pol2qm74 8438 15 post post NN cord-015021-pol2qm74 8438 16 dosing dosing NN cord-015021-pol2qm74 8438 17 with with IN cord-015021-pol2qm74 8438 18 lower low JJR cord-015021-pol2qm74 8438 19 mortality mortality NN cord-015021-pol2qm74 8438 20 rates rate NNS cord-015021-pol2qm74 8438 21 in in IN cord-015021-pol2qm74 8438 22 both both DT cord-015021-pol2qm74 8438 23 active active JJ cord-015021-pol2qm74 8438 24 treatment treatment NN cord-015021-pol2qm74 8438 25 arms arm NNS cord-015021-pol2qm74 8438 26 . . . cord-015021-pol2qm74 8439 1 Among among IN cord-015021-pol2qm74 8439 2 nonshock nonshock NN cord-015021-pol2qm74 8439 3 patients patient NNS cord-015021-pol2qm74 8439 4 TN~ TN~ NNP cord-015021-pol2qm74 8439 5 MAb MAb NNS cord-015021-pol2qm74 8439 6 did do VBD cord-015021-pol2qm74 8439 7 not not RB cord-015021-pol2qm74 8439 8 appear appear VB cord-015021-pol2qm74 8439 9 beneficial beneficial JJ cord-015021-pol2qm74 8439 10 . . . cord-015021-pol2qm74 8440 1 The the DT cord-015021-pol2qm74 8440 2 initial initial JJ cord-015021-pol2qm74 8440 3 clinical clinical JJ cord-015021-pol2qm74 8440 4 experience experience NN cord-015021-pol2qm74 8440 5 with with IN cord-015021-pol2qm74 8440 6 a a DT cord-015021-pol2qm74 8440 7 chimeric chimeric JJ cord-015021-pol2qm74 8440 8 anti anti JJ cord-015021-pol2qm74 8440 9 - - JJ cord-015021-pol2qm74 8440 10 TNF tnf JJ cord-015021-pol2qm74 8440 11 monoclonal monoclonal JJ cord-015021-pol2qm74 8440 12 antibody antibody NN cord-015021-pol2qm74 8440 13 , , , cord-015021-pol2qm74 8440 14 cA2 cA2 NNP cord-015021-pol2qm74 8440 15 , , , cord-015021-pol2qm74 8440 16 was be VBD cord-015021-pol2qm74 8440 17 undertaken undertake VBN cord-015021-pol2qm74 8440 18 in in IN cord-015021-pol2qm74 8440 19 septic septic JJ cord-015021-pol2qm74 8440 20 patients patient NNS cord-015021-pol2qm74 8440 21 . . . cord-015021-pol2qm74 8441 1 The the DT cord-015021-pol2qm74 8441 2 objectives objective NNS cord-015021-pol2qm74 8441 3 of of IN cord-015021-pol2qm74 8441 4 the the DT cord-015021-pol2qm74 8441 5 study study NN cord-015021-pol2qm74 8441 6 were be VBD cord-015021-pol2qm74 8441 7 to to TO cord-015021-pol2qm74 8441 8 determine determine VB cord-015021-pol2qm74 8441 9 the the DT cord-015021-pol2qm74 8441 10 safety safety NN cord-015021-pol2qm74 8441 11 , , , cord-015021-pol2qm74 8441 12 pharmacokinetics pharmacokinetic NNS cord-015021-pol2qm74 8441 13 and and CC cord-015021-pol2qm74 8441 14 effects effect NNS cord-015021-pol2qm74 8441 15 on on IN cord-015021-pol2qm74 8441 16 cytokine cytokine NN cord-015021-pol2qm74 8441 17 levels level NNS cord-015021-pol2qm74 8441 18 of of IN cord-015021-pol2qm74 8441 19 cA2 ca2 NN cord-015021-pol2qm74 8441 20 . . . cord-015021-pol2qm74 8442 1 as as IN cord-015021-pol2qm74 8442 2 a a DT cord-015021-pol2qm74 8442 3 single single JJ cord-015021-pol2qm74 8442 4 infusion infusion NN cord-015021-pol2qm74 8442 5 or or CC cord-015021-pol2qm74 8442 6 in in IN cord-015021-pol2qm74 8442 7 combination combination NN cord-015021-pol2qm74 8442 8 with with IN cord-015021-pol2qm74 8442 9 HA-1A HA-1A NNP cord-015021-pol2qm74 8442 10 in in IN cord-015021-pol2qm74 8442 11 septic septic JJ cord-015021-pol2qm74 8442 12 patients patient NNS cord-015021-pol2qm74 8442 13 . . . cord-015021-pol2qm74 8443 1 The the DT cord-015021-pol2qm74 8443 2 study study NN cord-015021-pol2qm74 8443 3 was be VBD cord-015021-pol2qm74 8443 4 conducted conduct VBN cord-015021-pol2qm74 8443 5 with with IN cord-015021-pol2qm74 8443 6 the the DT cord-015021-pol2qm74 8443 7 intent intent NN cord-015021-pol2qm74 8443 8 to to TO cord-015021-pol2qm74 8443 9 progress progress VB cord-015021-pol2qm74 8443 10 to to IN cord-015021-pol2qm74 8443 11 an an DT cord-015021-pol2qm74 8443 12 efficacy efficacy NN cord-015021-pol2qm74 8443 13 trial trial NN cord-015021-pol2qm74 8443 14 based base VBN cord-015021-pol2qm74 8443 15 on on IN cord-015021-pol2qm74 8443 16 the the DT cord-015021-pol2qm74 8443 17 information information NN cord-015021-pol2qm74 8443 18 collected collect VBN cord-015021-pol2qm74 8443 19 . . . cord-015021-pol2qm74 8444 1 The the DT cord-015021-pol2qm74 8444 2 trial trial NN cord-015021-pol2qm74 8444 3 was be VBD cord-015021-pol2qm74 8444 4 conducted conduct VBN cord-015021-pol2qm74 8444 5 in in IN cord-015021-pol2qm74 8444 6 three three CD cord-015021-pol2qm74 8444 7 stages stage NNS cord-015021-pol2qm74 8444 8 . . . cord-015021-pol2qm74 8445 1 Stage stage NN cord-015021-pol2qm74 8445 2 1 1 CD cord-015021-pol2qm74 8445 3 was be VBD cord-015021-pol2qm74 8445 4 an an DT cord-015021-pol2qm74 8445 5 open open JJ cord-015021-pol2qm74 8445 6 label label NN cord-015021-pol2qm74 8445 7 trial trial NN cord-015021-pol2qm74 8445 8 in in IN cord-015021-pol2qm74 8445 9 which which WDT cord-015021-pol2qm74 8445 10 4 4 CD cord-015021-pol2qm74 8445 11 groups group NNS cord-015021-pol2qm74 8445 12 of of IN cord-015021-pol2qm74 8445 13 5 5 CD cord-015021-pol2qm74 8445 14 patients patient NNS cord-015021-pol2qm74 8445 15 each each DT cord-015021-pol2qm74 8445 16 with with IN cord-015021-pol2qm74 8445 17 the the DT cord-015021-pol2qm74 8445 18 clinical clinical JJ cord-015021-pol2qm74 8445 19 diagnosis diagnosis NN cord-015021-pol2qm74 8445 20 of of IN cord-015021-pol2qm74 8445 21 sepsis sepsis NN cord-015021-pol2qm74 8445 22 received receive VBD cord-015021-pol2qm74 8445 23 ascending ascend VBG cord-015021-pol2qm74 8445 24 doses dose NNS cord-015021-pol2qm74 8445 25 of of IN cord-015021-pol2qm74 8445 26 cA2 ca2 NN cord-015021-pol2qm74 8445 27 ( ( -LRB- cord-015021-pol2qm74 8445 28 0.1 0.1 CD cord-015021-pol2qm74 8445 29 , , , cord-015021-pol2qm74 8445 30 1 1 CD cord-015021-pol2qm74 8445 31 , , , cord-015021-pol2qm74 8445 32 5 5 CD cord-015021-pol2qm74 8445 33 , , , cord-015021-pol2qm74 8445 34 10 10 CD cord-015021-pol2qm74 8445 35 mg mg NNP cord-015021-pol2qm74 8445 36 / / SYM cord-015021-pol2qm74 8445 37 kg kg NNP cord-015021-pol2qm74 8445 38 ) ) -RRB- cord-015021-pol2qm74 8445 39 . . . cord-015021-pol2qm74 8446 1 Stage stage NN cord-015021-pol2qm74 8446 2 2 2 CD cord-015021-pol2qm74 8446 3 was be VBD cord-015021-pol2qm74 8446 4 a a DT cord-015021-pol2qm74 8446 5 randomized randomized JJ cord-015021-pol2qm74 8446 6 , , , cord-015021-pol2qm74 8446 7 double double JJ cord-015021-pol2qm74 8446 8 blind blind JJ cord-015021-pol2qm74 8446 9 study study NN cord-015021-pol2qm74 8446 10 in in IN cord-015021-pol2qm74 8446 11 which which WDT cord-015021-pol2qm74 8446 12 patients patient NNS cord-015021-pol2qm74 8446 13 received receive VBD cord-015021-pol2qm74 8446 14 a a DT cord-015021-pol2qm74 8446 15 single single JJ cord-015021-pol2qm74 8446 16 dose dose NN cord-015021-pol2qm74 8446 17 of of IN cord-015021-pol2qm74 8446 18 HA-1A HA-1A NNP cord-015021-pol2qm74 8446 19 ( ( -LRB- cord-015021-pol2qm74 8446 20 100 100 CD cord-015021-pol2qm74 8446 21 mg mg NNS cord-015021-pol2qm74 8446 22 ) ) -RRB- cord-015021-pol2qm74 8446 23 and and CC cord-015021-pol2qm74 8446 24 placebo placebo NN cord-015021-pol2qm74 8446 25 or or CC cord-015021-pol2qm74 8446 26 one one CD cord-015021-pol2qm74 8446 27 of of IN cord-015021-pol2qm74 8446 28 3 3 CD cord-015021-pol2qm74 8446 29 doses dose NNS cord-015021-pol2qm74 8446 30 of of IN cord-015021-pol2qm74 8446 31 cA2 ca2 NN cord-015021-pol2qm74 8447 1 ( ( -LRB- cord-015021-pol2qm74 8447 2 1,5,10 1,5,10 NNP cord-015021-pol2qm74 8447 3 mg mg NNP cord-015021-pol2qm74 8447 4 / / SYM cord-015021-pol2qm74 8447 5 kg kg NNP cord-015021-pol2qm74 8447 6 ) ) -RRB- cord-015021-pol2qm74 8447 7 . . . cord-015021-pol2qm74 8448 1 Stage stage NN cord-015021-pol2qm74 8448 2 3 3 CD cord-015021-pol2qm74 8448 3 was be VBD cord-015021-pol2qm74 8448 4 a a DT cord-015021-pol2qm74 8448 5 randomized randomized JJ cord-015021-pol2qm74 8448 6 , , , cord-015021-pol2qm74 8448 7 double double JJ cord-015021-pol2qm74 8448 8 blind blind JJ cord-015021-pol2qm74 8448 9 study study NN cord-015021-pol2qm74 8448 10 in in IN cord-015021-pol2qm74 8448 11 which which WDT cord-015021-pol2qm74 8448 12 patients patient NNS cord-015021-pol2qm74 8448 13 received receive VBD cord-015021-pol2qm74 8448 14 a a DT cord-015021-pol2qm74 8448 15 single single JJ cord-015021-pol2qm74 8448 16 dose dose NN cord-015021-pol2qm74 8448 17 of of IN cord-015021-pol2qm74 8448 18 placebo placebo NN cord-015021-pol2qm74 8448 19 or or CC cord-015021-pol2qm74 8448 20 one one CD cord-015021-pol2qm74 8448 21 of of IN cord-015021-pol2qm74 8448 22 3 3 CD cord-015021-pol2qm74 8448 23 doses dose NNS cord-015021-pol2qm74 8448 24 of of IN cord-015021-pol2qm74 8448 25 cA2 ca2 NN cord-015021-pol2qm74 8448 26 ( ( -LRB- cord-015021-pol2qm74 8448 27 0.1 0.1 CD cord-015021-pol2qm74 8448 28 , , , cord-015021-pol2qm74 8448 29 1 1 CD cord-015021-pol2qm74 8448 30 , , , cord-015021-pol2qm74 8448 31 10 10 CD cord-015021-pol2qm74 8448 32 mg mg NNP cord-015021-pol2qm74 8448 33 / / SYM cord-015021-pol2qm74 8448 34 kg kg NNP cord-015021-pol2qm74 8448 35 ) ) -RRB- cord-015021-pol2qm74 8448 36 . . . cord-015021-pol2qm74 8449 1 In in IN cord-015021-pol2qm74 8449 2 addition addition NN cord-015021-pol2qm74 8449 3 to to IN cord-015021-pol2qm74 8449 4 usual usual JJ cord-015021-pol2qm74 8449 5 laboratory laboratory NN cord-015021-pol2qm74 8449 6 tests test NNS cord-015021-pol2qm74 8449 7 , , , cord-015021-pol2qm74 8449 8 the the DT cord-015021-pol2qm74 8449 9 following follow VBG cord-015021-pol2qm74 8449 10 assays assay NNS cord-015021-pol2qm74 8449 11 were be VBD cord-015021-pol2qm74 8449 12 performed perform VBN cord-015021-pol2qm74 8449 13 : : : cord-015021-pol2qm74 8449 14 chimeric chimeric JJ cord-015021-pol2qm74 8449 15 anti anti JJ cord-015021-pol2qm74 8449 16 - - JJ cord-015021-pol2qm74 8449 17 TNF TNF NNP cord-015021-pol2qm74 8449 18 concentration concentration NN cord-015021-pol2qm74 8449 19 , , , cord-015021-pol2qm74 8449 20 anti anti JJ cord-015021-pol2qm74 8449 21 - - JJ cord-015021-pol2qm74 8449 22 chimeric chimeric JJ cord-015021-pol2qm74 8449 23 antibody antibody NN cord-015021-pol2qm74 8449 24 , , , cord-015021-pol2qm74 8449 25 endotoxin endotoxin NN cord-015021-pol2qm74 8449 26 , , , cord-015021-pol2qm74 8449 27 TNF TNF NNP cord-015021-pol2qm74 8449 28 , , , cord-015021-pol2qm74 8449 29 IL-1 IL-1 NNP cord-015021-pol2qm74 8449 30 , , , cord-015021-pol2qm74 8449 31 and and CC cord-015021-pol2qm74 8449 32 IL-6 IL-6 NNP cord-015021-pol2qm74 8449 33 levels level NNS cord-015021-pol2qm74 8449 34 . . . cord-015021-pol2qm74 8450 1 A a DT cord-015021-pol2qm74 8450 2 total total NN cord-015021-pol2qm74 8450 3 of of IN cord-015021-pol2qm74 8450 4 141 141 CD cord-015021-pol2qm74 8450 5 patients patient NNS cord-015021-pol2qm74 8450 6 were be VBD cord-015021-pol2qm74 8450 7 enrolled enrol VBN cord-015021-pol2qm74 8450 8 from from IN cord-015021-pol2qm74 8450 9 13 13 CD cord-015021-pol2qm74 8450 10 clinical clinical JJ cord-015021-pol2qm74 8450 11 sites site NNS cord-015021-pol2qm74 8450 12 ( ( -LRB- cord-015021-pol2qm74 8450 13 20 20 CD cord-015021-pol2qm74 8450 14 in in IN cord-015021-pol2qm74 8450 15 stage stage NN cord-015021-pol2qm74 8450 16 1 1 CD cord-015021-pol2qm74 8450 17 , , , cord-015021-pol2qm74 8450 18 60 60 CD cord-015021-pol2qm74 8450 19 in in IN cord-015021-pol2qm74 8450 20 stage stage NN cord-015021-pol2qm74 8450 21 2 2 CD cord-015021-pol2qm74 8450 22 and and CC cord-015021-pol2qm74 8450 23 61 61 CD cord-015021-pol2qm74 8450 24 in in IN cord-015021-pol2qm74 8450 25 stage stage NN cord-015021-pol2qm74 8450 26 3 3 CD cord-015021-pol2qm74 8450 27 ) ) -RRB- cord-015021-pol2qm74 8450 28 . . . cord-015021-pol2qm74 8451 1 Primary primary JJ cord-015021-pol2qm74 8451 2 analyses analysis NNS cord-015021-pol2qm74 8451 3 were be VBD cord-015021-pol2qm74 8451 4 performed perform VBN cord-015021-pol2qm74 8451 5 on on IN cord-015021-pol2qm74 8451 6 patients patient NNS cord-015021-pol2qm74 8451 7 in in IN cord-015021-pol2qm74 8451 8 stage stage NN cord-015021-pol2qm74 8451 9 1 1 CD cord-015021-pol2qm74 8451 10 and and CC cord-015021-pol2qm74 8451 11 3 3 CD cord-015021-pol2qm74 8451 12 . . . cord-015021-pol2qm74 8452 1 There there EX cord-015021-pol2qm74 8452 2 were be VBD cord-015021-pol2qm74 8452 3 65 65 CD cord-015021-pol2qm74 8452 4 patients patient NNS cord-015021-pol2qm74 8452 5 who who WP cord-015021-pol2qm74 8452 6 received receive VBD cord-015021-pol2qm74 8452 7 cA2 ca2 NN cord-015021-pol2qm74 8452 8 exclusively exclusively RB cord-015021-pol2qm74 8452 9 and and CC cord-015021-pol2qm74 8452 10 16 16 CD cord-015021-pol2qm74 8452 11 patients patient NNS cord-015021-pol2qm74 8452 12 received receive VBD cord-015021-pol2qm74 8452 13 placebo placebo NN cord-015021-pol2qm74 8452 14 . . . cord-015021-pol2qm74 8453 1 Administration administration NN cord-015021-pol2qm74 8453 2 of of IN cord-015021-pol2qm74 8453 3 cA2 cA2 NNP cord-015021-pol2qm74 8453 4 was be VBD cord-015021-pol2qm74 8453 5 well well RB cord-015021-pol2qm74 8453 6 tolerated tolerate VBN cord-015021-pol2qm74 8453 7 at at IN cord-015021-pol2qm74 8453 8 doses dose NNS cord-015021-pol2qm74 8453 9 up up IN cord-015021-pol2qm74 8453 10 to to TO cord-015021-pol2qm74 8453 11 10 10 CD cord-015021-pol2qm74 8453 12 mg mg NN cord-015021-pol2qm74 8453 13 / / SYM cord-015021-pol2qm74 8453 14 kg kg NNS cord-015021-pol2qm74 8453 15 . . . cord-015021-pol2qm74 8454 1 No no DT cord-015021-pol2qm74 8454 2 patient patient NN cord-015021-pol2qm74 8454 3 discontinued discontinue VBD cord-015021-pol2qm74 8454 4 treatment treatment NN cord-015021-pol2qm74 8454 5 due due IN cord-015021-pol2qm74 8454 6 to to IN cord-015021-pol2qm74 8454 7 adverse adverse JJ cord-015021-pol2qm74 8454 8 events event NNS cord-015021-pol2qm74 8454 9 . . . cord-015021-pol2qm74 8455 1 Human human JJ cord-015021-pol2qm74 8455 2 anti anti JJ cord-015021-pol2qm74 8455 3 - - JJ cord-015021-pol2qm74 8455 4 chimeric chimeric JJ cord-015021-pol2qm74 8455 5 antibody antibody NN cord-015021-pol2qm74 8455 6 responses response NNS cord-015021-pol2qm74 8455 7 were be VBD cord-015021-pol2qm74 8455 8 positive positive JJ cord-015021-pol2qm74 8455 9 in in IN cord-015021-pol2qm74 8455 10 61 61 CD cord-015021-pol2qm74 8455 11 % % NN cord-015021-pol2qm74 8455 12 ( ( -LRB- cord-015021-pol2qm74 8455 13 30/49 30/49 CD cord-015021-pol2qm74 8455 14 ) ) -RRB- cord-015021-pol2qm74 8455 15 of of IN cord-015021-pol2qm74 8455 16 evaluated evaluate VBN cord-015021-pol2qm74 8455 17 patients patient NNS cord-015021-pol2qm74 8455 18 . . . cord-015021-pol2qm74 8456 1 Mean Mean NNP cord-015021-pol2qm74 8456 2 Cma Cma NNP cord-015021-pol2qm74 8456 3 × × NNP cord-015021-pol2qm74 8456 4 and and CC cord-015021-pol2qm74 8456 5 AUC AUC NNP cord-015021-pol2qm74 8456 6 increased increase VBD cord-015021-pol2qm74 8456 7 proportionally proportionally RB cord-015021-pol2qm74 8456 8 with with IN cord-015021-pol2qm74 8456 9 increasing increase VBG cord-015021-pol2qm74 8456 10 doses dose NNS cord-015021-pol2qm74 8456 11 of of IN cord-015021-pol2qm74 8456 12 cA2 ca2 NN cord-015021-pol2qm74 8456 13 . . . cord-015021-pol2qm74 8457 1 The the DT cord-015021-pol2qm74 8457 2 mean mean JJ cord-015021-pol2qm74 8457 3 half half JJ cord-015021-pol2qm74 8457 4 - - HYPH cord-015021-pol2qm74 8457 5 life life NN cord-015021-pol2qm74 8457 6 was be VBD cord-015021-pol2qm74 8457 7 -70 -70 NN cord-015021-pol2qm74 8457 8 hrs hrs NN cord-015021-pol2qm74 8457 9 ( ( -LRB- cord-015021-pol2qm74 8457 10 58 58 CD cord-015021-pol2qm74 8457 11 - - SYM cord-015021-pol2qm74 8457 12 96 96 CD cord-015021-pol2qm74 8457 13 hrs hrs NN cord-015021-pol2qm74 8457 14 ) ) -RRB- cord-015021-pol2qm74 8457 15 . . . cord-015021-pol2qm74 8458 1 A a DT cord-015021-pol2qm74 8458 2 dose dose NN cord-015021-pol2qm74 8458 3 related relate VBN cord-015021-pol2qm74 8458 4 decrease decrease NN cord-015021-pol2qm74 8458 5 in in IN cord-015021-pol2qm74 8458 6 TNF TNF NNP cord-015021-pol2qm74 8458 7 concentration concentration NN cord-015021-pol2qm74 8458 8 was be VBD cord-015021-pol2qm74 8458 9 observed observe VBN cord-015021-pol2qm74 8458 10 1 1 CD cord-015021-pol2qm74 8458 11 hr hr NN cord-015021-pol2qm74 8458 12 post post NN cord-015021-pol2qm74 8458 13 infusion infusion NN cord-015021-pol2qm74 8458 14 of of IN cord-015021-pol2qm74 8458 15 cA2 ca2 NN cord-015021-pol2qm74 8458 16 . . . cord-015021-pol2qm74 8459 1 TNF TNF NNP cord-015021-pol2qm74 8459 2 is be VBZ cord-015021-pol2qm74 8459 3 considered consider VBN cord-015021-pol2qm74 8459 4 to to TO cord-015021-pol2qm74 8459 5 be be VB cord-015021-pol2qm74 8459 6 one one CD cord-015021-pol2qm74 8459 7 of of IN cord-015021-pol2qm74 8459 8 the the DT cord-015021-pol2qm74 8459 9 central central JJ cord-015021-pol2qm74 8459 10 endogenous endogenous JJ cord-015021-pol2qm74 8459 11 mediators mediator NNS cord-015021-pol2qm74 8459 12 for for IN cord-015021-pol2qm74 8459 13 the the DT cord-015021-pol2qm74 8459 14 inili'ation inili'ation NN cord-015021-pol2qm74 8459 15 of of IN cord-015021-pol2qm74 8459 16 the the DT cord-015021-pol2qm74 8459 17 pathophysiological pathophysiological JJ cord-015021-pol2qm74 8459 18 changes change NNS cord-015021-pol2qm74 8459 19 in in IN cord-015021-pol2qm74 8459 20 patients patient NNS cord-015021-pol2qm74 8459 21 with with IN cord-015021-pol2qm74 8459 22 sepsis sepsis NN cord-015021-pol2qm74 8459 23 and and CC cord-015021-pol2qm74 8459 24 septic septic JJ cord-015021-pol2qm74 8459 25 shock shock NN cord-015021-pol2qm74 8459 26 . . . cord-015021-pol2qm74 8460 1 High high JJ cord-015021-pol2qm74 8460 2 TNF TNF NNP cord-015021-pol2qm74 8460 3 levels level NNS cord-015021-pol2qm74 8460 4 were be VBD cord-015021-pol2qm74 8460 5 demonstrated demonstrate VBN cord-015021-pol2qm74 8460 6 to to TO cord-015021-pol2qm74 8460 7 correlate correlate VB cord-015021-pol2qm74 8460 8 with with IN cord-015021-pol2qm74 8460 9 patient patient JJ cord-015021-pol2qm74 8460 10 outcome outcome NN cord-015021-pol2qm74 8460 11 . . . cord-015021-pol2qm74 8461 1 Blocking block VBG cord-015021-pol2qm74 8461 2 or or CC cord-015021-pol2qm74 8461 3 neutralising neutralise VBG cord-015021-pol2qm74 8461 4 TNF TNF NNP cord-015021-pol2qm74 8461 5 with with IN cord-015021-pol2qm74 8461 6 specific specific JJ cord-015021-pol2qm74 8461 7 antibodies antibody NNS cord-015021-pol2qm74 8461 8 was be VBD cord-015021-pol2qm74 8461 9 effective effective JJ cord-015021-pol2qm74 8461 10 in in IN cord-015021-pol2qm74 8461 11 preventing prevent VBG cord-015021-pol2qm74 8461 12 death death NN cord-015021-pol2qm74 8461 13 in in IN cord-015021-pol2qm74 8461 14 some some DT cord-015021-pol2qm74 8461 15 animal animal NN cord-015021-pol2qm74 8461 16 modets modet NNS cord-015021-pol2qm74 8461 17 of of IN cord-015021-pol2qm74 8461 18 sepsis sepsis NN cord-015021-pol2qm74 8461 19 . . . cord-015021-pol2qm74 8462 1 In in IN cord-015021-pol2qm74 8462 2 a a DT cord-015021-pol2qm74 8462 3 placebo placebo NN cord-015021-pol2qm74 8462 4 controlled control VBN cord-015021-pol2qm74 8462 5 prospective prospective JJ cord-015021-pol2qm74 8462 6 randomized randomized JJ cord-015021-pol2qm74 8462 7 study study NN cord-015021-pol2qm74 8462 8 we -PRON- PRP cord-015021-pol2qm74 8462 9 tested test VBD cord-015021-pol2qm74 8462 10 the the DT cord-015021-pol2qm74 8462 11 mur~ mur~ CD cord-015021-pol2qm74 8463 1 ne ne NNP cord-015021-pol2qm74 8463 2 derived derive VBD cord-015021-pol2qm74 8463 3 antibody antibody NN cord-015021-pol2qm74 8463 4 MAK MAK NNP cord-015021-pol2qm74 8463 5 195F. 195f. CD cord-015021-pol2qm74 8464 1 It -PRON- PRP cord-015021-pol2qm74 8464 2 is be VBZ cord-015021-pol2qm74 8464 3 a a DT cord-015021-pol2qm74 8464 4 F(ab')2 F(ab')2 NNP cord-015021-pol2qm74 8464 5 fragment fragment NN cord-015021-pol2qm74 8464 6 . . . cord-015021-pol2qm74 8465 1 The the DT cord-015021-pol2qm74 8465 2 fragment fragment NN cord-015021-pol2qm74 8465 3 rather rather RB cord-015021-pol2qm74 8465 4 the the DT cord-015021-pol2qm74 8465 5 complete complete JJ cord-015021-pol2qm74 8465 6 antibody antibody NN cord-015021-pol2qm74 8465 7 was be VBD cord-015021-pol2qm74 8465 8 selected select VBN cord-015021-pol2qm74 8465 9 in in IN cord-015021-pol2qm74 8465 10 order order NN cord-015021-pol2qm74 8465 11 to to TO cord-015021-pol2qm74 8465 12 reduce reduce VB cord-015021-pol2qm74 8465 13 the the DT cord-015021-pol2qm74 8465 14 potential potential JJ cord-015021-pol2qm74 8465 15 immunogenicity immunogenicity NN cord-015021-pol2qm74 8465 16 and and CC cord-015021-pol2qm74 8465 17 to to TO cord-015021-pol2qm74 8465 18 facilitate facilitate VB cord-015021-pol2qm74 8465 19 tissue tissue NN cord-015021-pol2qm74 8465 20 penetration penetration NN cord-015021-pol2qm74 8465 21 . . . cord-015021-pol2qm74 8466 1 122 122 CD cord-015021-pol2qm74 8466 2 patients patient NNS cord-015021-pol2qm74 8466 3 with with IN cord-015021-pol2qm74 8466 4 severe severe JJ cord-015021-pol2qm74 8466 5 sepsis sepsis NN cord-015021-pol2qm74 8466 6 or or CC cord-015021-pol2qm74 8466 7 septic septic NN cord-015021-pol2qm74 8466 8 shdck shdck NNP cord-015021-pol2qm74 8466 9 were be VBD cord-015021-pol2qm74 8466 10 enrolied enrolie VBN cord-015021-pol2qm74 8466 11 in in IN cord-015021-pol2qm74 8466 12 the the DT cord-015021-pol2qm74 8466 13 study study NN cord-015021-pol2qm74 8466 14 , , , cord-015021-pol2qm74 8466 15 three three CD cord-015021-pol2qm74 8466 16 different different JJ cord-015021-pol2qm74 8466 17 doses dose NNS cord-015021-pol2qm74 8466 18 of of IN cord-015021-pol2qm74 8466 19 MAK MAK NNP cord-015021-pol2qm74 8466 20 195F 195f CD cord-015021-pol2qm74 8466 21 or or CC cord-015021-pol2qm74 8466 22 placebo placebo NN cord-015021-pol2qm74 8466 23 were be VBD cord-015021-pol2qm74 8466 24 administered administer VBN cord-015021-pol2qm74 8466 25 ( ( -LRB- cord-015021-pol2qm74 8466 26 0,1 0,1 CD cord-015021-pol2qm74 8466 27 ; ; : cord-015021-pol2qm74 8466 28 0,3 0,3 NFP cord-015021-pol2qm74 8466 29 and and CC cord-015021-pol2qm74 8466 30 I -PRON- PRP cord-015021-pol2qm74 8466 31 mg mg NNP cord-015021-pol2qm74 8466 32 / / SYM cord-015021-pol2qm74 8466 33 kg kg NNP cord-015021-pol2qm74 8466 34 ) ) -RRB- cord-015021-pol2qm74 8466 35 over over IN cord-015021-pol2qm74 8466 36 a a DT cord-015021-pol2qm74 8466 37 perid perid NN cord-015021-pol2qm74 8466 38 of of IN cord-015021-pol2qm74 8466 39 72 72 CD cord-015021-pol2qm74 8466 40 hours hour NNS cord-015021-pol2qm74 8466 41 in in IN cord-015021-pol2qm74 8466 42 random random JJ cord-015021-pol2qm74 8466 43 order order NN cord-015021-pol2qm74 8466 44 . . . cord-015021-pol2qm74 8467 1 The the DT cord-015021-pol2qm74 8467 2 patients patient NNS cord-015021-pol2qm74 8467 3 were be VBD cord-015021-pol2qm74 8467 4 evaluated evaluate VBN cord-015021-pol2qm74 8467 5 for for IN cord-015021-pol2qm74 8467 6 side side JJ cord-015021-pol2qm74 8467 7 effects effect NNS cord-015021-pol2qm74 8467 8 , , , cord-015021-pol2qm74 8467 9 hemodynamics hemodynamic NNS cord-015021-pol2qm74 8467 10 , , , cord-015021-pol2qm74 8467 11 organ organ NN cord-015021-pol2qm74 8467 12 dysfunction dysfunction NN cord-015021-pol2qm74 8467 13 , , , cord-015021-pol2qm74 8467 14 cytokines cytokine NNS cord-015021-pol2qm74 8467 15 ( ( -LRB- cord-015021-pol2qm74 8467 16 IL IL NNP cord-015021-pol2qm74 8467 17 6 6 CD cord-015021-pol2qm74 8467 18 , , , cord-015021-pol2qm74 8467 19 IL IL NNP cord-015021-pol2qm74 8467 20 8 8 CD cord-015021-pol2qm74 8467 21 and and CC cord-015021-pol2qm74 8467 22 TNF TNF NNP cord-015021-pol2qm74 8467 23 ) ) -RRB- cord-015021-pol2qm74 8467 24 , , , cord-015021-pol2qm74 8467 25 and and CC cord-015021-pol2qm74 8467 26 outcome outcome NN cord-015021-pol2qm74 8467 27 . . . cord-015021-pol2qm74 8468 1 At at IN cord-015021-pol2qm74 8468 2 this this DT cord-015021-pol2qm74 8468 3 time time NN cord-015021-pol2qm74 8468 4 only only RB cord-015021-pol2qm74 8468 5 an an DT cord-015021-pol2qm74 8468 6 interim interim JJ cord-015021-pol2qm74 8468 7 analysis analysis NN cord-015021-pol2qm74 8468 8 of of IN cord-015021-pol2qm74 8468 9 60 60 CD cord-015021-pol2qm74 8468 10 patients patient NNS cord-015021-pol2qm74 8468 11 is be VBZ cord-015021-pol2qm74 8468 12 available available JJ cord-015021-pol2qm74 8468 13 I -PRON- PRP cord-015021-pol2qm74 8468 14 indicating indicate VBG cord-015021-pol2qm74 8468 15 that that IN cord-015021-pol2qm74 8468 16 MAK MAK NNP cord-015021-pol2qm74 8468 17 195F 195f CD cord-015021-pol2qm74 8468 18 in in IN cord-015021-pol2qm74 8468 19 all all DT cord-015021-pol2qm74 8468 20 3 3 CD cord-015021-pol2qm74 8468 21 dosage dosage NN cord-015021-pol2qm74 8468 22 groups group NNS cord-015021-pol2qm74 8468 23 resulted result VBD cord-015021-pol2qm74 8468 24 in in IN cord-015021-pol2qm74 8468 25 a a DT cord-015021-pol2qm74 8468 26 decrease decrease NN cord-015021-pol2qm74 8468 27 in in IN cord-015021-pol2qm74 8468 28 IL IL NNP cord-015021-pol2qm74 8468 29 6 6 CD cord-015021-pol2qm74 8468 30 . . . cord-015021-pol2qm74 8469 1 This this DT cord-015021-pol2qm74 8469 2 contrasted contrast VBD cord-015021-pol2qm74 8469 3 to to IN cord-015021-pol2qm74 8469 4 a a DT cord-015021-pol2qm74 8469 5 further far RBR cord-015021-pol2qm74 8469 6 in in IN cord-015021-pol2qm74 8469 7 crease crease NN cord-015021-pol2qm74 8469 8 of of IN cord-015021-pol2qm74 8469 9 IL IL NNP cord-015021-pol2qm74 8469 10 6 6 CD cord-015021-pol2qm74 8469 11 in in IN cord-015021-pol2qm74 8469 12 the the DT cord-015021-pol2qm74 8469 13 placebo placebo NN cord-015021-pol2qm74 8469 14 patients patient NNS cord-015021-pol2qm74 8469 15 . . . cord-015021-pol2qm74 8470 1 No no DT cord-015021-pol2qm74 8470 2 serious serious JJ cord-015021-pol2qm74 8470 3 side side NN cord-015021-pol2qm74 8470 4 effects effect NNS cord-015021-pol2qm74 8470 5 have have VBP cord-015021-pol2qm74 8470 6 been be VBN cord-015021-pol2qm74 8470 7 reported report VBN cord-015021-pol2qm74 8470 8 so so RB cord-015021-pol2qm74 8470 9 far far RB cord-015021-pol2qm74 8470 10 . . . cord-015021-pol2qm74 8471 1 A a DT cord-015021-pol2qm74 8471 2 more more RBR cord-015021-pol2qm74 8471 3 detailed detailed JJ cord-015021-pol2qm74 8471 4 analysis analysis NN cord-015021-pol2qm74 8471 5 on on IN cord-015021-pol2qm74 8471 6 all all DT cord-015021-pol2qm74 8471 7 122 122 CD cord-015021-pol2qm74 8471 8 patients patient NNS cord-015021-pol2qm74 8471 9 in in IN cord-015021-pol2qm74 8471 10 the the DT cord-015021-pol2qm74 8471 11 study study NN cord-015021-pol2qm74 8471 12 will will MD cord-015021-pol2qm74 8471 13 be be VB cord-015021-pol2qm74 8471 14 presented present VBN cord-015021-pol2qm74 8471 15 and and CC cord-015021-pol2qm74 8471 16 discussed.$152 discussed.$152 VBN cord-015021-pol2qm74 8471 17 S154 S154 NNP cord-015021-pol2qm74 8471 18 Staubach Staubach NNP cord-015021-pol2qm74 8471 19 , , , cord-015021-pol2qm74 8471 20 K.H. K.H. NNP cord-015021-pol2qm74 8471 21 , , , cord-015021-pol2qm74 8471 22 Otto Otto NNP cord-015021-pol2qm74 8471 23 , , , cord-015021-pol2qm74 8471 24 V. V. NNP cord-015021-pol2qm74 8471 25 , , , cord-015021-pol2qm74 8471 26 Kooistra Kooistra NNP cord-015021-pol2qm74 8471 27 , , , cord-015021-pol2qm74 8471 28 A A NNP cord-015021-pol2qm74 8471 29 , , , cord-015021-pol2qm74 8471 30 , , , cord-015021-pol2qm74 8471 31 RosenfeId RosenfeId NNP cord-015021-pol2qm74 8471 32 , , , cord-015021-pol2qm74 8471 33 J.A. J.A. NNP cord-015021-pol2qm74 8471 34 , , , cord-015021-pol2qm74 8471 35 Bruch Bruch NNP cord-015021-pol2qm74 8471 36 , , , cord-015021-pol2qm74 8471 37 H.P. H.P. NNP cord-015021-pol2qm74 8471 38 , , , cord-015021-pol2qm74 8471 39 Univ Univ NNP cord-015021-pol2qm74 8471 40 . . . cord-015021-pol2qm74 8472 1 Lfibeek Lfibeek NNP cord-015021-pol2qm74 8472 2 , , , cord-015021-pol2qm74 8472 3 Germany Germany NNP cord-015021-pol2qm74 8473 1 Once once IN cord-015021-pol2qm74 8473 2 endotoxinemia endotoxinemia NN cord-015021-pol2qm74 8473 3 occurs occur VBZ cord-015021-pol2qm74 8473 4 in in IN cord-015021-pol2qm74 8473 5 sepsis sepsis NN cord-015021-pol2qm74 8473 6 a a DT cord-015021-pol2qm74 8473 7 vieieus vieieus NN cord-015021-pol2qm74 8473 8 cycle cycle NN cord-015021-pol2qm74 8473 9 with with IN cord-015021-pol2qm74 8473 10 translocation translocation NN cord-015021-pol2qm74 8473 11 of of IN cord-015021-pol2qm74 8473 12 ET ET NNP cord-015021-pol2qm74 8473 13 can can MD cord-015021-pol2qm74 8473 14 be be VB cord-015021-pol2qm74 8473 15 established establish VBN cord-015021-pol2qm74 8473 16 . . . cord-015021-pol2qm74 8474 1 Increasing increase VBG cord-015021-pol2qm74 8474 2 the the DT cord-015021-pol2qm74 8474 3 clearance clearance NN cord-015021-pol2qm74 8474 4 capacity capacity NN cord-015021-pol2qm74 8474 5 for for IN cord-015021-pol2qm74 8474 6 ET ET NNP cord-015021-pol2qm74 8474 7 would would MD cord-015021-pol2qm74 8474 8 therapeutically therapeutically RB cord-015021-pol2qm74 8474 9 be be VB cord-015021-pol2qm74 8474 10 the the DT cord-015021-pol2qm74 8474 11 ulimate ulimate JJ cord-015021-pol2qm74 8474 12 aim aim NN cord-015021-pol2qm74 8474 13 . . . cord-015021-pol2qm74 8475 1 We -PRON- PRP cord-015021-pol2qm74 8475 2 developed develop VBD cord-015021-pol2qm74 8475 3 a a DT cord-015021-pol2qm74 8475 4 new new JJ cord-015021-pol2qm74 8475 5 ET ET NNP cord-015021-pol2qm74 8475 6 on on IN cord-015021-pol2qm74 8475 7 - - HYPH cord-015021-pol2qm74 8475 8 line line NN cord-015021-pol2qm74 8475 9 adsorption adsorption NN cord-015021-pol2qm74 8475 10 ( ( -LRB- cord-015021-pol2qm74 8475 11 AD ad NN cord-015021-pol2qm74 8475 12 ) ) -RRB- cord-015021-pol2qm74 8475 13 system system NN cord-015021-pol2qm74 8475 14 in in IN cord-015021-pol2qm74 8475 15 whole whole JJ cord-015021-pol2qm74 8475 16 blood blood NN cord-015021-pol2qm74 8475 17 by by IN cord-015021-pol2qm74 8475 18 means mean NNS cord-015021-pol2qm74 8475 19 of of IN cord-015021-pol2qm74 8475 20 Polymyxin Polymyxin NNP cord-015021-pol2qm74 8475 21 B B NNP cord-015021-pol2qm74 8475 22 ( ( -LRB- cord-015021-pol2qm74 8475 23 PB PB NNP cord-015021-pol2qm74 8475 24 ) ) -RRB- cord-015021-pol2qm74 8475 25 coupled couple VBN cord-015021-pol2qm74 8475 26 eovalently eovalently RB cord-015021-pol2qm74 8475 27 to to IN cord-015021-pol2qm74 8475 28 a a DT cord-015021-pol2qm74 8475 29 matrix matrix NN cord-015021-pol2qm74 8475 30 ( ( -LRB- cord-015021-pol2qm74 8475 31 acrylic acrylic NN cord-015021-pol2qm74 8475 32 particles particle NNS cord-015021-pol2qm74 8475 33 ) ) -RRB- cord-015021-pol2qm74 8475 34 via via IN cord-015021-pol2qm74 8475 35 a a DT cord-015021-pol2qm74 8475 36 13 13 CD cord-015021-pol2qm74 8475 37 atom atom NN cord-015021-pol2qm74 8475 38 - - HYPH cord-015021-pol2qm74 8475 39 chain chain NN cord-015021-pol2qm74 8475 40 spacer spacer NN cord-015021-pol2qm74 8475 41 . . . cord-015021-pol2qm74 8476 1 The the DT cord-015021-pol2qm74 8476 2 detoxification detoxification NN cord-015021-pol2qm74 8476 3 capacity capacity NN cord-015021-pol2qm74 8476 4 was be VBD cord-015021-pol2qm74 8476 5 150 150 CD cord-015021-pol2qm74 8476 6 ug[ET ug[ET NNP cord-015021-pol2qm74 8476 7 / / SYM cord-015021-pol2qm74 8476 8 ml ml NN cord-015021-pol2qm74 8476 9 column column NN cord-015021-pol2qm74 8476 10 material material NN cord-015021-pol2qm74 8476 11 . . . cord-015021-pol2qm74 8477 1 The the DT cord-015021-pol2qm74 8477 2 biocompatbility biocompatbility NN cord-015021-pol2qm74 8477 3 resulted result VBD cord-015021-pol2qm74 8477 4 in in IN cord-015021-pol2qm74 8477 5 90~ 90~ CD cord-015021-pol2qm74 8477 6 platelet platelet NN cord-015021-pol2qm74 8477 7 recovery recovery NN cord-015021-pol2qm74 8477 8 . . . cord-015021-pol2qm74 8478 1 The the DT cord-015021-pol2qm74 8478 2 column column NN cord-015021-pol2qm74 8478 3 contained contain VBD cord-015021-pol2qm74 8478 4 7 7 CD cord-015021-pol2qm74 8478 5 ml ml NNS cord-015021-pol2qm74 8478 6 of of IN cord-015021-pol2qm74 8478 7 ADmaterial ADmaterial NNP cord-015021-pol2qm74 8478 8 and and CC cord-015021-pol2qm74 8478 9 was be VBD cord-015021-pol2qm74 8478 10 sterilized sterilize VBN cord-015021-pol2qm74 8478 11 by by IN cord-015021-pol2qm74 8478 12 high high JJ cord-015021-pol2qm74 8478 13 steam steam NN cord-015021-pol2qm74 8478 14 autoclave autoclave NN cord-015021-pol2qm74 8478 15 , , , cord-015021-pol2qm74 8478 16 Anticoagulation Anticoagulation NNP cord-015021-pol2qm74 8478 17 was be VBD cord-015021-pol2qm74 8478 18 achieved achieve VBN cord-015021-pol2qm74 8478 19 by by IN cord-015021-pol2qm74 8478 20 heparine heparine NNP cord-015021-pol2qm74 8478 21 1.000 1.000 CD cord-015021-pol2qm74 8478 22 IU IU NNP cord-015021-pol2qm74 8478 23 / / SYM cord-015021-pol2qm74 8478 24 h h NN cord-015021-pol2qm74 8478 25 in in IN cord-015021-pol2qm74 8478 26 the the DT cord-015021-pol2qm74 8478 27 inflowline inflowline NN cord-015021-pol2qm74 8478 28 after after IN cord-015021-pol2qm74 8478 29 bolus bolus NN cord-015021-pol2qm74 8478 30 injection injection NN cord-015021-pol2qm74 8478 31 of of IN cord-015021-pol2qm74 8478 32 5.000 5.000 CD cord-015021-pol2qm74 8478 33 IU IU NNP cord-015021-pol2qm74 8478 34 . . . cord-015021-pol2qm74 8479 1 HP HP NNP cord-015021-pol2qm74 8479 2 was be VBD cord-015021-pol2qm74 8479 3 performed perform VBN cord-015021-pol2qm74 8479 4 on on IN cord-015021-pol2qm74 8479 5 8 8 CD cord-015021-pol2qm74 8479 6 pigs pig NNS cord-015021-pol2qm74 8479 7 at at IN cord-015021-pol2qm74 8479 8 a a DT cord-015021-pol2qm74 8479 9 rate rate NN cord-015021-pol2qm74 8479 10 of of IN cord-015021-pol2qm74 8479 11 50 50 CD cord-015021-pol2qm74 8479 12 ml ml NNS cord-015021-pol2qm74 8479 13 / / SYM cord-015021-pol2qm74 8479 14 min min NN cord-015021-pol2qm74 8479 15 by by IN cord-015021-pol2qm74 8479 16 means mean NNS cord-015021-pol2qm74 8479 17 of of IN cord-015021-pol2qm74 8479 18 a a DT cord-015021-pol2qm74 8479 19 roller roller NN cord-015021-pol2qm74 8479 20 - - HYPH cord-015021-pol2qm74 8479 21 pump pump NN cord-015021-pol2qm74 8479 22 until until IN cord-015021-pol2qm74 8479 23 the the DT cord-015021-pol2qm74 8479 24 animals animal NNS cord-015021-pol2qm74 8479 25 succumbed succumb VBD cord-015021-pol2qm74 8479 26 ( ( -LRB- cord-015021-pol2qm74 8479 27 H h NN cord-015021-pol2qm74 8479 28 ) ) -RRB- cord-015021-pol2qm74 8479 29 . . . cord-015021-pol2qm74 8480 1 8 8 CD cord-015021-pol2qm74 8480 2 animals animal NNS cord-015021-pol2qm74 8480 3 served serve VBD cord-015021-pol2qm74 8480 4 as as IN cord-015021-pol2qm74 8480 5 controls control NNS cord-015021-pol2qm74 8480 6 ( ( -LRB- cord-015021-pol2qm74 8480 7 C C NNP cord-015021-pol2qm74 8480 8 ) ) -RRB- cord-015021-pol2qm74 8480 9 . . . cord-015021-pol2qm74 8481 1 Serum serum NN cord-015021-pol2qm74 8481 2 ET ET NNP cord-015021-pol2qm74 8481 3 levels level NNS cord-015021-pol2qm74 8481 4 rose rise VBD cord-015021-pol2qm74 8481 5 from from IN cord-015021-pol2qm74 8481 6 3.40 3.40 CD cord-015021-pol2qm74 8481 7 pg pg NNP cord-015021-pol2qm74 8481 8 / / SYM cord-015021-pol2qm74 8481 9 ml ml NN cord-015021-pol2qm74 8481 10 to to IN cord-015021-pol2qm74 8481 11 74,9 74,9 CD cord-015021-pol2qm74 8481 12 pg pg NN cord-015021-pol2qm74 8481 13 / / SYM cord-015021-pol2qm74 8481 14 ml ml NN cord-015021-pol2qm74 8481 15 after after IN cord-015021-pol2qm74 8481 16 5 5 CD cord-015021-pol2qm74 8481 17 hours hour NNS cord-015021-pol2qm74 8481 18 in in IN cord-015021-pol2qm74 8481 19 the the DT cord-015021-pol2qm74 8481 20 C C NNP cord-015021-pol2qm74 8481 21 and and CC cord-015021-pol2qm74 8481 22 from from IN cord-015021-pol2qm74 8481 23 2.77 2.77 CD cord-015021-pol2qm74 8481 24 pg pg NNP cord-015021-pol2qm74 8481 25 / / SYM cord-015021-pol2qm74 8481 26 ml ml XX cord-015021-pol2qm74 8481 27 only only RB cord-015021-pol2qm74 8481 28 to to IN cord-015021-pol2qm74 8481 29 28 28 CD cord-015021-pol2qm74 8481 30 pg pg NNP cord-015021-pol2qm74 8481 31 / / SYM cord-015021-pol2qm74 8481 32 ml ml XX cord-015021-pol2qm74 8481 33 in in IN cord-015021-pol2qm74 8481 34 the the DT cord-015021-pol2qm74 8481 35 H H NNP cord-015021-pol2qm74 8481 36 group group NN cord-015021-pol2qm74 8481 37 after after IN cord-015021-pol2qm74 8481 38 7 7 CD cord-015021-pol2qm74 8481 39 hours hour NNS cord-015021-pol2qm74 8481 40 whieh whieh NNP cord-015021-pol2qm74 8481 41 was be VBD cord-015021-pol2qm74 8481 42 highly highly RB cord-015021-pol2qm74 8481 43 significant significant JJ cord-015021-pol2qm74 8481 44 . . . cord-015021-pol2qm74 8482 1 Survival survival NN cord-015021-pol2qm74 8482 2 time time NN cord-015021-pol2qm74 8482 3 could could MD cord-015021-pol2qm74 8482 4 be be VB cord-015021-pol2qm74 8482 5 extrended extrende VBN cord-015021-pol2qm74 8482 6 from from IN cord-015021-pol2qm74 8482 7 216 216 CD cord-015021-pol2qm74 8482 8 to to IN cord-015021-pol2qm74 8482 9 313 313 CD cord-015021-pol2qm74 8482 10 min min NN cord-015021-pol2qm74 8482 11 . . . cord-015021-pol2qm74 8483 1 Results result NNS cord-015021-pol2qm74 8483 2 are be VBP cord-015021-pol2qm74 8483 3 listed list VBN cord-015021-pol2qm74 8483 4 in in IN cord-015021-pol2qm74 8483 5 the the DT cord-015021-pol2qm74 8483 6 following follow VBG cord-015021-pol2qm74 8483 7 L. L. NNP cord-015021-pol2qm74 8483 8 Blinzler Blinzler NNP cord-015021-pol2qm74 8483 9 , , , cord-015021-pol2qm74 8483 10 P. P. NNP cord-015021-pol2qm74 8483 11 Zaar Zaar NNP cord-015021-pol2qm74 8483 12 , , , cord-015021-pol2qm74 8483 13 M. M. NNP cord-015021-pol2qm74 8483 14 Leier Leier NNP cord-015021-pol2qm74 8483 15 , , , cord-015021-pol2qm74 8483 16 R. R. NNP cord-015021-pol2qm74 8483 17 B(2rger B(2rger NNP cord-015021-pol2qm74 8483 18 , , , cord-015021-pol2qm74 8483 19 D. D. NNP cord-015021-pol2qm74 8483 20 Heuser Heuser NNP cord-015021-pol2qm74 8483 21 Clinic Clinic NNP cord-015021-pol2qm74 8483 22 of of IN cord-015021-pol2qm74 8483 23 Anaesthesiology Anaesthesiology NNP cord-015021-pol2qm74 8483 24 , , , cord-015021-pol2qm74 8483 25 City City NNP cord-015021-pol2qm74 8483 26 Hospital Hospital NNP cord-015021-pol2qm74 8483 27 Nuremberg Nuremberg NNP cord-015021-pol2qm74 8483 28 , , , cord-015021-pol2qm74 8483 29 Germany Germany NNP cord-015021-pol2qm74 8483 30 Sepsis Sepsis NNP cord-015021-pol2qm74 8483 31 and and CC cord-015021-pol2qm74 8483 32 multiple multiple JJ cord-015021-pol2qm74 8483 33 organ organ NN cord-015021-pol2qm74 8483 34 failure failure NN cord-015021-pol2qm74 8483 35 ( ( -LRB- cord-015021-pol2qm74 8483 36 MOF MOF NNP cord-015021-pol2qm74 8483 37 ) ) -RRB- cord-015021-pol2qm74 8483 38 are be VBP cord-015021-pol2qm74 8483 39 still still RB cord-015021-pol2qm74 8483 40 related relate VBN cord-015021-pol2qm74 8483 41 with with IN cord-015021-pol2qm74 8483 42 poor poor JJ cord-015021-pol2qm74 8483 43 prognosis prognosis NN cord-015021-pol2qm74 8483 44 inspire inspire NN cord-015021-pol2qm74 8483 45 of of IN cord-015021-pol2qm74 8483 46 pharmacological pharmacological JJ cord-015021-pol2qm74 8483 47 and and CC cord-015021-pol2qm74 8483 48 technical technical JJ cord-015021-pol2qm74 8483 49 progress progress NN cord-015021-pol2qm74 8483 50 . . . cord-015021-pol2qm74 8484 1 Impressed impress VBN cord-015021-pol2qm74 8484 2 by by IN cord-015021-pol2qm74 8484 3 revealing reveal VBG cord-015021-pol2qm74 8484 4 reports report NNS cord-015021-pol2qm74 8484 5 about about IN cord-015021-pol2qm74 8484 6 blood blood NN cord-015021-pol2qm74 8484 7 purification purification NN cord-015021-pol2qm74 8484 8 the the DT cord-015021-pol2qm74 8484 9 continuous continuous JJ cord-015021-pol2qm74 8484 10 veno veno NNP cord-015021-pol2qm74 8484 11 - - HYPH cord-015021-pol2qm74 8484 12 venous venous JJ cord-015021-pol2qm74 8484 13 hemofiltration hemofiltration NNP cord-015021-pol2qm74 8484 14 ( ( -LRB- cord-015021-pol2qm74 8484 15 CVVH CVVH NNP cord-015021-pol2qm74 8484 16 ) ) -RRB- cord-015021-pol2qm74 8484 17 was be VBD cord-015021-pol2qm74 8484 18 used use VBN cord-015021-pol2qm74 8484 19 as as IN cord-015021-pol2qm74 8484 20 supporting support VBG cord-015021-pol2qm74 8484 21 treatment treatment NN cord-015021-pol2qm74 8484 22 beside beside IN cord-015021-pol2qm74 8484 23 the the DT cord-015021-pol2qm74 8484 24 critical critical JJ cord-015021-pol2qm74 8484 25 cam cam NN cord-015021-pol2qm74 8484 26 basic basic JJ cord-015021-pol2qm74 8484 27 therapy therapy NN cord-015021-pol2qm74 8484 28 of of IN cord-015021-pol2qm74 8484 29 MOF MOF NNP cord-015021-pol2qm74 8484 30 . . . cord-015021-pol2qm74 8485 1 From from IN cord-015021-pol2qm74 8485 2 1989 1989 CD cord-015021-pol2qm74 8485 3 to to IN cord-015021-pol2qm74 8485 4 1991 1991 CD cord-015021-pol2qm74 8485 5 78 78 CD cord-015021-pol2qm74 8485 6 consecutive consecutive JJ cord-015021-pol2qm74 8485 7 patients patient NNS cord-015021-pol2qm74 8485 8 were be VBD cord-015021-pol2qm74 8485 9 treated treat VBN cord-015021-pol2qm74 8485 10 by by IN cord-015021-pol2qm74 8485 11 CWH CWH NNP cord-015021-pol2qm74 8485 12 . . . cord-015021-pol2qm74 8486 1 MOF MOF NNP cord-015021-pol2qm74 8486 2 was be VBD cord-015021-pol2qm74 8486 3 caused cause VBN cord-015021-pol2qm74 8486 4 by by IN cord-015021-pol2qm74 8486 5 hemolrhagic hemolrhagic JJ cord-015021-pol2qm74 8486 6 - - HYPH cord-015021-pol2qm74 8486 7 traumatic traumatic JJ cord-015021-pol2qm74 8486 8 noxa noxa NN cord-015021-pol2qm74 8486 9 in in IN cord-015021-pol2qm74 8486 10 21 21 CD cord-015021-pol2qm74 8486 11 ° ° NNS cord-015021-pol2qm74 8486 12 ,4 ,4 NNS cord-015021-pol2qm74 8486 13 and and CC cord-015021-pol2qm74 8486 14 by by IN cord-015021-pol2qm74 8486 15 septic septic JJ cord-015021-pol2qm74 8486 16 - - HYPH cord-015021-pol2qm74 8486 17 toxic toxic JJ cord-015021-pol2qm74 8486 18 event event NN cord-015021-pol2qm74 8486 19 in in IN cord-015021-pol2qm74 8486 20 79 79 CD cord-015021-pol2qm74 8486 21 % % NN cord-015021-pol2qm74 8486 22 . . . cord-015021-pol2qm74 8487 1 All all DT cord-015021-pol2qm74 8487 2 patients patient NNS cord-015021-pol2qm74 8487 3 required require VBD cord-015021-pol2qm74 8487 4 mechanical mechanical JJ cord-015021-pol2qm74 8487 5 ventilation ventilation NN cord-015021-pol2qm74 8487 6 ( ( -LRB- cord-015021-pol2qm74 8487 7 FiO2>0 fio2>0 CD cord-015021-pol2qm74 8487 8 , , , cord-015021-pol2qm74 8487 9 5 5 CD cord-015021-pol2qm74 8487 10 ) ) -RRB- cord-015021-pol2qm74 8487 11 . . . cord-015021-pol2qm74 8488 1 86 86 CD cord-015021-pol2qm74 8488 2 ° ° NN cord-015021-pol2qm74 8488 3 4 4 CD cord-015021-pol2qm74 8488 4 showed show VBD cord-015021-pol2qm74 8488 5 hyperdynamic hyperdynamic JJ cord-015021-pol2qm74 8488 6 shock shock NN cord-015021-pol2qm74 8488 7 . . . cord-015021-pol2qm74 8489 1 85 85 CD cord-015021-pol2qm74 8489 2 % % NN cord-015021-pol2qm74 8489 3 had have VBD cord-015021-pol2qm74 8489 4 renal renal JJ cord-015021-pol2qm74 8489 5 and and CC cord-015021-pol2qm74 8489 6 53 53 CD cord-015021-pol2qm74 8489 7 % % NN cord-015021-pol2qm74 8489 8 hepatic hepatic JJ cord-015021-pol2qm74 8489 9 failure failure NN cord-015021-pol2qm74 8489 10 . . . cord-015021-pol2qm74 8490 1 Medium Medium NNP cord-015021-pol2qm74 8490 2 APPACHE APPACHE NNP cord-015021-pol2qm74 8490 3 II II NNP cord-015021-pol2qm74 8490 4 score score NN cord-015021-pol2qm74 8490 5 amounted amount VBD cord-015021-pol2qm74 8490 6 to to IN cord-015021-pol2qm74 8490 7 29,8 29,8 CD cord-015021-pol2qm74 8490 8 points point NNS cord-015021-pol2qm74 8490 9 . . . cord-015021-pol2qm74 8491 1 CVVH CVVH NNP cord-015021-pol2qm74 8491 2 was be VBD cord-015021-pol2qm74 8491 3 performed perform VBN cord-015021-pol2qm74 8491 4 in in IN cord-015021-pol2qm74 8491 5 postdilution postdilution NN cord-015021-pol2qm74 8491 6 mode mode NN cord-015021-pol2qm74 8491 7 with with IN cord-015021-pol2qm74 8491 8 a a DT cord-015021-pol2qm74 8491 9 polyamide polyamide NN cord-015021-pol2qm74 8491 10 membrane membrane NN cord-015021-pol2qm74 8491 11 ( ( -LRB- cord-015021-pol2qm74 8491 12 FH FH NNP cord-015021-pol2qm74 8491 13 66 66 CD cord-015021-pol2qm74 8491 14 ) ) -RRB- cord-015021-pol2qm74 8491 15 and and CC cord-015021-pol2qm74 8491 16 high high JJ cord-015021-pol2qm74 8491 17 volume volume NN cord-015021-pol2qm74 8491 18 exchange exchange NN cord-015021-pol2qm74 8491 19 ( ( -LRB- cord-015021-pol2qm74 8491 20 50 50 CD cord-015021-pol2qm74 8491 21 l l NN cord-015021-pol2qm74 8491 22 / / SYM cord-015021-pol2qm74 8491 23 die die NN cord-015021-pol2qm74 8491 24 ) ) -RRB- cord-015021-pol2qm74 8491 25 . . . cord-015021-pol2qm74 8492 1 Anticoagulation Anticoagulation NNP cord-015021-pol2qm74 8492 2 was be VBD cord-015021-pol2qm74 8492 3 done do VBN cord-015021-pol2qm74 8492 4 with with IN cord-015021-pol2qm74 8492 5 heparin heparin NN cord-015021-pol2qm74 8492 6 . . . cord-015021-pol2qm74 8493 1 Hemofiltration Hemofiltration NNP cord-015021-pol2qm74 8493 2 in in IN cord-015021-pol2qm74 8493 3 MOF MOF NNP cord-015021-pol2qm74 8493 4 was be VBD cord-015021-pol2qm74 8493 5 installed instal VBN cord-015021-pol2qm74 8493 6 , , , cord-015021-pol2qm74 8493 7 when when WRB cord-015021-pol2qm74 8493 8 critical critical JJ cord-015021-pol2qm74 8493 9 cam cam NN cord-015021-pol2qm74 8493 10 basic basic JJ cord-015021-pol2qm74 8493 11 therapy therapy NN cord-015021-pol2qm74 8493 12 including include VBG cord-015021-pol2qm74 8493 13 adequate adequate JJ cord-015021-pol2qm74 8493 14 respiratory respiratory JJ cord-015021-pol2qm74 8493 15 and and CC cord-015021-pol2qm74 8493 16 hemodynamic hemodynamic JJ cord-015021-pol2qm74 8493 17 management management NN cord-015021-pol2qm74 8493 18 , , , cord-015021-pol2qm74 8493 19 pamnteral pamnteral JJ cord-015021-pol2qm74 8493 20 nutrition nutrition NN cord-015021-pol2qm74 8493 21 , , , cord-015021-pol2qm74 8493 22 antibiotic antibiotic JJ cord-015021-pol2qm74 8493 23 treatment treatment NN cord-015021-pol2qm74 8493 24 , , , cord-015021-pol2qm74 8493 25 etc etc FW cord-015021-pol2qm74 8493 26 . . FW cord-015021-pol2qm74 8493 27 , , , cord-015021-pol2qm74 8493 28 failed fail VBD cord-015021-pol2qm74 8493 29 to to TO cord-015021-pol2qm74 8493 30 stabilize stabilize VB cord-015021-pol2qm74 8493 31 organ organ NN cord-015021-pol2qm74 8493 32 functions function NNS cord-015021-pol2qm74 8493 33 . . . cord-015021-pol2qm74 8494 1 During during IN cord-015021-pol2qm74 8494 2 consequent consequent JJ cord-015021-pol2qm74 8494 3 application application NN cord-015021-pol2qm74 8494 4 of of IN cord-015021-pol2qm74 8494 5 CVVH CVVH NNP cord-015021-pol2qm74 8494 6 most most JJS cord-015021-pol2qm74 8494 7 of of IN cord-015021-pol2qm74 8494 8 these these DT cord-015021-pol2qm74 8494 9 patients patient NNS cord-015021-pol2qm74 8494 10 showed show VBD cord-015021-pol2qm74 8494 11 improvement improvement NN cord-015021-pol2qm74 8494 12 of of IN cord-015021-pol2qm74 8494 13 their -PRON- PRP$ cord-015021-pol2qm74 8494 14 clinical clinical JJ cord-015021-pol2qm74 8494 15 course course NN cord-015021-pol2qm74 8494 16 . . . cord-015021-pol2qm74 8495 1 Pulmonary pulmonary JJ cord-015021-pol2qm74 8495 2 stabilization stabilization NN cord-015021-pol2qm74 8495 3 was be VBD cord-015021-pol2qm74 8495 4 seen see VBN cord-015021-pol2qm74 8495 5 in in IN cord-015021-pol2qm74 8495 6 71 71 CD cord-015021-pol2qm74 8495 7 % % NN cord-015021-pol2qm74 8495 8 , , , cord-015021-pol2qm74 8495 9 hemodynamic hemodynamic JJ cord-015021-pol2qm74 8495 10 in in IN cord-015021-pol2qm74 8495 11 68 68 CD cord-015021-pol2qm74 8495 12 % % NN cord-015021-pol2qm74 8495 13 and and CC cord-015021-pol2qm74 8495 14 renal renal JJ cord-015021-pol2qm74 8495 15 in in IN cord-015021-pol2qm74 8495 16 66 66 CD cord-015021-pol2qm74 8495 17 % % NN cord-015021-pol2qm74 8495 18 of of IN cord-015021-pol2qm74 8495 19 the the DT cord-015021-pol2qm74 8495 20 cases case NNS cord-015021-pol2qm74 8495 21 . . . cord-015021-pol2qm74 8496 1 42 42 CD cord-015021-pol2qm74 8496 2 % % NN cord-015021-pol2qm74 8496 3 of of IN cord-015021-pol2qm74 8496 4 the the DT cord-015021-pol2qm74 8496 5 patients patient NNS cord-015021-pol2qm74 8496 6 survived survive VBD cord-015021-pol2qm74 8496 7 and and CC cord-015021-pol2qm74 8496 8 were be VBD cord-015021-pol2qm74 8496 9 discharged discharge VBN cord-015021-pol2qm74 8496 10 from from IN cord-015021-pol2qm74 8496 11 hospital hospital NN cord-015021-pol2qm74 8496 12 . . . cord-015021-pol2qm74 8497 1 10 10 CD cord-015021-pol2qm74 8497 2 of of IN cord-015021-pol2qm74 8497 3 45 45 CD cord-015021-pol2qm74 8497 4 non non NNS cord-015021-pol2qm74 8497 5 - - NNS cord-015021-pol2qm74 8497 6 survivors survivor NNS cord-015021-pol2qm74 8497 7 ( ( -LRB- cord-015021-pol2qm74 8497 8 58 58 CD cord-015021-pol2qm74 8497 9 % % NN cord-015021-pol2qm74 8497 10 ) ) -RRB- cord-015021-pol2qm74 8497 11 died die VBD cord-015021-pol2qm74 8497 12 because because IN cord-015021-pol2qm74 8497 13 of of IN cord-015021-pol2qm74 8497 14 fatal fatal JJ cord-015021-pol2qm74 8497 15 MOF MOF NNP cord-015021-pol2qm74 8497 16 within within IN cord-015021-pol2qm74 8497 17 24h 24h NNS cord-015021-pol2qm74 8497 18 after after IN cord-015021-pol2qm74 8497 19 admission admission NN cord-015021-pol2qm74 8497 20 to to IN cord-015021-pol2qm74 8497 21 ICU ICU NNP cord-015021-pol2qm74 8497 22 . . . cord-015021-pol2qm74 8498 1 Patients patient NNS cord-015021-pol2qm74 8498 2 with with IN cord-015021-pol2qm74 8498 3 early early JJ cord-015021-pol2qm74 8498 4 application application NN cord-015021-pol2qm74 8498 5 of of IN cord-015021-pol2qm74 8498 6 CVVH CVVH NNP cord-015021-pol2qm74 8498 7 in in IN cord-015021-pol2qm74 8498 8 MOF MOF NNP cord-015021-pol2qm74 8498 9 showed show VBD cord-015021-pol2qm74 8498 10 a a DT cord-015021-pol2qm74 8498 11 better well JJR cord-015021-pol2qm74 8498 12 survival survival NN cord-015021-pol2qm74 8498 13 rate rate NN cord-015021-pol2qm74 8498 14 . . . cord-015021-pol2qm74 8499 1 Mediators mediator NNS cord-015021-pol2qm74 8499 2 of of IN cord-015021-pol2qm74 8499 3 MOF MOF NNP cord-015021-pol2qm74 8499 4 , , , cord-015021-pol2qm74 8499 5 i.e. i.e. FW cord-015021-pol2qm74 8499 6 products product NNS cord-015021-pol2qm74 8499 7 of of IN cord-015021-pol2qm74 8499 8 the the DT cord-015021-pol2qm74 8499 9 complement complement NN cord-015021-pol2qm74 8499 10 cascade cascade NN cord-015021-pol2qm74 8499 11 measured measure VBN cord-015021-pol2qm74 8499 12 in in IN cord-015021-pol2qm74 8499 13 blood blood NN cord-015021-pol2qm74 8499 14 and and CC cord-015021-pol2qm74 8499 15 nitrafiltrate nitrafiltrate NN cord-015021-pol2qm74 8499 16 by by IN cord-015021-pol2qm74 8499 17 ELISA ELISA NNP cord-015021-pol2qm74 8499 18 , , , cord-015021-pol2qm74 8499 19 were be VBD cord-015021-pol2qm74 8499 20 partially partially RB cord-015021-pol2qm74 8499 21 removed remove VBN cord-015021-pol2qm74 8499 22 by by IN cord-015021-pol2qm74 8499 23 CVVH CVVH NNP cord-015021-pol2qm74 8499 24 . . . cord-015021-pol2qm74 8500 1 The the DT cord-015021-pol2qm74 8500 2 testing testing NN cord-015021-pol2qm74 8500 3 ultrafiltrate ultrafiltrate NN cord-015021-pol2qm74 8500 4 by by IN cord-015021-pol2qm74 8500 5 HPLC HPLC NNP cord-015021-pol2qm74 8500 6 demonstrated demonstrate VBD cord-015021-pol2qm74 8500 7 decreasing decrease VBG cord-015021-pol2qm74 8500 8 spikes spike NNS cord-015021-pol2qm74 8500 9 ofpolypeptides ofpolypeptide NNS cord-015021-pol2qm74 8500 10 during during IN cord-015021-pol2qm74 8500 11 hemofiltration hemofiltration NN cord-015021-pol2qm74 8500 12 . . . cord-015021-pol2qm74 8501 1 MOF MOF NNP cord-015021-pol2qm74 8501 2 seems seem VBZ cord-015021-pol2qm74 8501 3 to to TO cord-015021-pol2qm74 8501 4 be be VB cord-015021-pol2qm74 8501 5 generated generate VBN cord-015021-pol2qm74 8501 6 by by IN cord-015021-pol2qm74 8501 7 cascade cascade NN cord-015021-pol2qm74 8501 8 - - HYPH cord-015021-pol2qm74 8501 9 activation activation NN cord-015021-pol2qm74 8501 10 of of IN cord-015021-pol2qm74 8501 11 immune immune JJ cord-015021-pol2qm74 8501 12 competent competent JJ cord-015021-pol2qm74 8501 13 cells cell NNS cord-015021-pol2qm74 8501 14 and and CC cord-015021-pol2qm74 8501 15 plasmatic plasmatic JJ cord-015021-pol2qm74 8501 16 mediators mediator NNS cord-015021-pol2qm74 8501 17 ( ( -LRB- cord-015021-pol2qm74 8501 18 e.g. e.g. NNP cord-015021-pol2qm74 8501 19 bmdykinin bmdykinin NNP cord-015021-pol2qm74 8501 20 , , , cord-015021-pol2qm74 8501 21 eicosanoides eicosanoide NNS cord-015021-pol2qm74 8501 22 , , , cord-015021-pol2qm74 8501 23 cytokines cytokine NNS cord-015021-pol2qm74 8501 24 , , , cord-015021-pol2qm74 8501 25 anaphylatoxins anaphylatoxin NNS cord-015021-pol2qm74 8501 26 , , , cord-015021-pol2qm74 8501 27 etc etc FW cord-015021-pol2qm74 8501 28 . . . cord-015021-pol2qm74 8501 29 ) ) -RRB- cord-015021-pol2qm74 8501 30 . . . cord-015021-pol2qm74 8502 1 Therapeutic therapeutic JJ cord-015021-pol2qm74 8502 2 approaches approach NNS cord-015021-pol2qm74 8502 3 aim aim VBP cord-015021-pol2qm74 8502 4 to to TO cord-015021-pol2qm74 8502 5 inactivate inactivate VB cord-015021-pol2qm74 8502 6 or or CC cord-015021-pol2qm74 8502 7 eliminate eliminate VB cord-015021-pol2qm74 8502 8 single single JJ cord-015021-pol2qm74 8502 9 substances substance NNS cord-015021-pol2qm74 8502 10 . . . cord-015021-pol2qm74 8503 1 CWH cwh NN cord-015021-pol2qm74 8503 2 with with IN cord-015021-pol2qm74 8503 3 high high JJ cord-015021-pol2qm74 8503 4 - - HYPH cord-015021-pol2qm74 8503 5 flux flux NN cord-015021-pol2qm74 8503 6 membranes membrane NNS cord-015021-pol2qm74 8503 7 in in IN cord-015021-pol2qm74 8503 8 combination combination NN cord-015021-pol2qm74 8503 9 with with IN cord-015021-pol2qm74 8503 10 high high JJ cord-015021-pol2qm74 8503 11 - - HYPH cord-015021-pol2qm74 8503 12 volume volume NN cord-015021-pol2qm74 8503 13 exchange exchange NN cord-015021-pol2qm74 8503 14 allows allow VBZ cord-015021-pol2qm74 8503 15 elimination elimination NN cord-015021-pol2qm74 8503 16 of of IN cord-015021-pol2qm74 8503 17 many many JJ cord-015021-pol2qm74 8503 18 mediators mediator NNS cord-015021-pol2qm74 8503 19 with with IN cord-015021-pol2qm74 8503 20 different different JJ cord-015021-pol2qm74 8503 21 molecular molecular JJ cord-015021-pol2qm74 8503 22 weight weight NN cord-015021-pol2qm74 8503 23 and and CC cord-015021-pol2qm74 8503 24 therefore therefore RB cord-015021-pol2qm74 8503 25 may may MD cord-015021-pol2qm74 8503 26 contribute contribute VB cord-015021-pol2qm74 8503 27 to to TO cord-015021-pol2qm74 8503 28 improve improve VB cord-015021-pol2qm74 8503 29 the the DT cord-015021-pol2qm74 8503 30 prognosis prognosis NN cord-015021-pol2qm74 8503 31 of of IN cord-015021-pol2qm74 8503 32 MOF MOF NNP cord-015021-pol2qm74 8503 33 . . . cord-015021-pol2qm74 8504 1 Other other JJ cord-015021-pol2qm74 8504 2 significant significant JJ cord-015021-pol2qm74 8504 3 advantages advantage NNS cord-015021-pol2qm74 8504 4 of of IN cord-015021-pol2qm74 8504 5 this this DT cord-015021-pol2qm74 8504 6 teqalnique teqalnique NN cord-015021-pol2qm74 8504 7 like like IN cord-015021-pol2qm74 8504 8 adequate adequate JJ cord-015021-pol2qm74 8504 9 nutrition nutrition NN cord-015021-pol2qm74 8504 10 , , , cord-015021-pol2qm74 8504 11 optimized optimize VBN cord-015021-pol2qm74 8504 12 fluid fluid JJ cord-015021-pol2qm74 8504 13 balance balance NN cord-015021-pol2qm74 8504 14 and and CC cord-015021-pol2qm74 8504 15 control control NN cord-015021-pol2qm74 8504 16 of of IN cord-015021-pol2qm74 8504 17 body body NN cord-015021-pol2qm74 8504 18 temperature temperature NN cord-015021-pol2qm74 8504 19 should should MD cord-015021-pol2qm74 8504 20 not not RB cord-015021-pol2qm74 8504 21 be be VB cord-015021-pol2qm74 8504 22 negicctod negicctod NNP cord-015021-pol2qm74 8504 23 . . . cord-015021-pol2qm74 8505 1 Introductioni Introductioni NNP cord-015021-pol2qm74 8505 2 Pseudomonas Pseudomonas NNP cord-015021-pol2qm74 8505 3 ( ( -LRB- cord-015021-pol2qm74 8505 4 P p NN cord-015021-pol2qm74 8505 5 ) ) -RRB- cord-015021-pol2qm74 8505 6 aeruginosa aeruginosa NN cord-015021-pol2qm74 8505 7 has have VBZ cord-015021-pol2qm74 8505 8 to to TO cord-015021-pol2qm74 8505 9 be be VB cord-015021-pol2qm74 8505 10 considered consider VBN cord-015021-pol2qm74 8505 11 an an DT cord-015021-pol2qm74 8505 12 important important JJ cord-015021-pol2qm74 8505 13 pathogen pathogen NN cord-015021-pol2qm74 8505 14 of of IN cord-015021-pol2qm74 8505 15 nosocomial nosocomial JJ cord-015021-pol2qm74 8505 16 pneumonia pneumonia NN cord-015021-pol2qm74 8505 17 and and CC cord-015021-pol2qm74 8505 18 septic septic JJ cord-015021-pol2qm74 8505 19 organ organ NN cord-015021-pol2qm74 8505 20 failure failure NN cord-015021-pol2qm74 8505 21 . . . cord-015021-pol2qm74 8506 1 The the DT cord-015021-pol2qm74 8506 2 lung lung NN cord-015021-pol2qm74 8506 3 seems seem VBZ cord-015021-pol2qm74 8506 4 to to TO cord-015021-pol2qm74 8506 5 be be VB cord-015021-pol2qm74 8506 6 the the DT cord-015021-pol2qm74 8506 7 predominant predominant JJ cord-015021-pol2qm74 8506 8 target target NN cord-015021-pol2qm74 8506 9 organ organ NN cord-015021-pol2qm74 8506 10 for for IN cord-015021-pol2qm74 8506 11 the the DT cord-015021-pol2qm74 8506 12 pore pore NN cord-015021-pol2qm74 8506 13 - - HYPH cord-015021-pol2qm74 8506 14 forming form VBG cord-015021-pol2qm74 8506 15 P. P. NNP cord-015021-pol2qm74 8506 16 aeruginosa aeruginosa NN cord-015021-pol2qm74 8506 17 cytotoxin cytotoxin NN cord-015021-pol2qm74 8506 18 , , , cord-015021-pol2qm74 8506 19 thus thus RB cord-015021-pol2qm74 8506 20 inducing induce VBG cord-015021-pol2qm74 8506 21 microvascular microvascular JJ cord-015021-pol2qm74 8506 22 injury injury NN cord-015021-pol2qm74 8506 23 . . . cord-015021-pol2qm74 8507 1 With with IN cord-015021-pol2qm74 8507 2 respect respect NN cord-015021-pol2qm74 8507 3 to to IN cord-015021-pol2qm74 8507 4 therapeutical therapeutical JJ cord-015021-pol2qm74 8507 5 consequences consequence NNS cord-015021-pol2qm74 8507 6 , , , cord-015021-pol2qm74 8507 7 the the DT cord-015021-pol2qm74 8507 8 potential potential JJ cord-015021-pol2qm74 8507 9 protective protective JJ cord-015021-pol2qm74 8507 10 effects effect NNS cord-015021-pol2qm74 8507 11 of of IN cord-015021-pol2qm74 8507 12 PAF PAF NNP cord-015021-pol2qm74 8507 13 - - HYPH cord-015021-pol2qm74 8507 14 antagonist antagonist NN cord-015021-pol2qm74 8507 15 ( ( -LRB- cord-015021-pol2qm74 8507 16 WEB web NN cord-015021-pol2qm74 8507 17 2086 2086 CD cord-015021-pol2qm74 8507 18 ) ) -RRB- cord-015021-pol2qm74 8507 19 , , , cord-015021-pol2qm74 8507 20 cyelooxygenase cyelooxygenase NNP cord-015021-pol2qm74 8507 21 inhibitor inhibitor NN cord-015021-pol2qm74 8507 22 ( ( -LRB- cord-015021-pol2qm74 8507 23 diclofenac diclofenac NNP cord-015021-pol2qm74 8507 24 ) ) -RRB- cord-015021-pol2qm74 8507 25 and and CC cord-015021-pol2qm74 8507 26 specific specific JJ cord-015021-pol2qm74 8507 27 and and CC cord-015021-pol2qm74 8507 28 unspecific unspecific JJ cord-015021-pol2qm74 8507 29 antibodies antibody NNS cord-015021-pol2qm74 8507 30 on on IN cord-015021-pol2qm74 8507 31 cytotoxin cytotoxin NN cord-015021-pol2qm74 8507 32 - - HYPH cord-015021-pol2qm74 8507 33 induced induce VBN cord-015021-pol2qm74 8507 34 pulmonary pulmonary JJ cord-015021-pol2qm74 8507 35 vascular vascular JJ cord-015021-pol2qm74 8507 36 reaction reaction NN cord-015021-pol2qm74 8507 37 and and CC cord-015021-pol2qm74 8507 38 mediator mediator NN cord-015021-pol2qm74 8507 39 release release NN cord-015021-pol2qm74 8507 40 were be VBD cord-015021-pol2qm74 8507 41 studied study VBN cord-015021-pol2qm74 8507 42 in in IN cord-015021-pol2qm74 8507 43 the the DT cord-015021-pol2qm74 8507 44 isolated isolate VBN cord-015021-pol2qm74 8507 45 perfused perfuse VBN cord-015021-pol2qm74 8507 46 rabbit rabbit NN cord-015021-pol2qm74 8507 47 lung lung NN cord-015021-pol2qm74 8507 48 . . . cord-015021-pol2qm74 8508 1 Methods method NNS cord-015021-pol2qm74 8508 2 : : : cord-015021-pol2qm74 8508 3 Cytotoxin Cytotoxin NNP cord-015021-pol2qm74 8508 4 ( ( -LRB- cord-015021-pol2qm74 8508 5 6p_g 6p_g CD cord-015021-pol2qm74 8508 6 / / SYM cord-015021-pol2qm74 8508 7 ml ml NN cord-015021-pol2qm74 8508 8 ) ) -RRB- cord-015021-pol2qm74 8508 9 was be VBD cord-015021-pol2qm74 8508 10 administered administer VBN cord-015021-pol2qm74 8508 11 into into IN cord-015021-pol2qm74 8508 12 the the DT cord-015021-pol2qm74 8508 13 perfusion perfusion NN cord-015021-pol2qm74 8508 14 fluid fluid NN cord-015021-pol2qm74 8508 15 in in IN cord-015021-pol2qm74 8508 16 all all DT cord-015021-pol2qm74 8508 17 groups group NNS cord-015021-pol2qm74 8508 18 , , , cord-015021-pol2qm74 8508 19 either either CC cord-015021-pol2qm74 8508 20 in in IN cord-015021-pol2qm74 8508 21 the the DT cord-015021-pol2qm74 8508 22 absence absence NN cord-015021-pol2qm74 8508 23 of of IN cord-015021-pol2qm74 8508 24 inhibitors inhibitor NNS cord-015021-pol2qm74 8508 25 ( ( -LRB- cord-015021-pol2qm74 8508 26 n=6 n=6 NNP cord-015021-pol2qm74 8508 27 ) ) -RRB- cord-015021-pol2qm74 8508 28 , , , cord-015021-pol2qm74 8508 29 or or CC cord-015021-pol2qm74 8508 30 after after IN cord-015021-pol2qm74 8508 31 pretreatment pretreatment NN cord-015021-pol2qm74 8508 32 with with IN cord-015021-pol2qm74 8508 33 WEB web NN cord-015021-pol2qm74 8508 34 2086 2086 CD cord-015021-pol2qm74 8508 35 ( ( -LRB- cord-015021-pol2qm74 8508 36 5xl0-gM 5xl0-gm CD cord-015021-pol2qm74 8508 37 , , , cord-015021-pol2qm74 8508 38 n=6 n=6 NNP cord-015021-pol2qm74 8508 39 ) ) -RRB- cord-015021-pol2qm74 8508 40 , , , cord-015021-pol2qm74 8508 41 or or CC cord-015021-pol2qm74 8508 42 diclofenac diclofenac NNP cord-015021-pol2qm74 8508 43 ( ( -LRB- cord-015021-pol2qm74 8508 44 10#g 10#g NNP cord-015021-pol2qm74 8508 45 / / SYM cord-015021-pol2qm74 8508 46 ml ml NN cord-015021-pol2qm74 8508 47 , , , cord-015021-pol2qm74 8508 48 n-6 n-6 NNP cord-015021-pol2qm74 8508 49 ) ) -RRB- cord-015021-pol2qm74 8508 50 . . . cord-015021-pol2qm74 8509 1 Furthermore furthermore RB cord-015021-pol2qm74 8509 2 , , , cord-015021-pol2qm74 8509 3 the the DT cord-015021-pol2qm74 8509 4 application application NN cord-015021-pol2qm74 8509 5 of of IN cord-015021-pol2qm74 8509 6 specific specific JJ cord-015021-pol2qm74 8509 7 antitoxin antitoxin NN cord-015021-pol2qm74 8509 8 ( ( -LRB- cord-015021-pol2qm74 8509 9 mg mg NNP cord-015021-pol2qm74 8509 10 / / SYM cord-015021-pol2qm74 8509 11 ml ml NNP cord-015021-pol2qm74 8509 12 , , , cord-015021-pol2qm74 8509 13 n=6 n=6 NNP cord-015021-pol2qm74 8509 14 ) ) -RRB- cord-015021-pol2qm74 8509 15 was be VBD cord-015021-pol2qm74 8509 16 tested test VBN cord-015021-pol2qm74 8509 17 in in IN cord-015021-pol2qm74 8509 18 comparison comparison NN cord-015021-pol2qm74 8509 19 with with IN cord-015021-pol2qm74 8509 20 the the DT cord-015021-pol2qm74 8509 21 unspecific unspecific JJ cord-015021-pol2qm74 8509 22 immunoglobulins immunoglobulin NNS cord-015021-pol2qm74 8509 23 ( ( -LRB- cord-015021-pol2qm74 8509 24 Venimmun Venimmun NNP cord-015021-pol2qm74 8509 25 ® ® POS cord-015021-pol2qm74 8509 26 , , , cord-015021-pol2qm74 8509 27 Behring Behring NNP cord-015021-pol2qm74 8509 28 , , , cord-015021-pol2qm74 8509 29 7.5 7.5 CD cord-015021-pol2qm74 8509 30 mg mg NNP cord-015021-pol2qm74 8509 31 / / SYM cord-015021-pol2qm74 8509 32 ml ml NN cord-015021-pol2qm74 8509 33 ) ) -RRB- cord-015021-pol2qm74 8509 34 ( ( -LRB- cord-015021-pol2qm74 8509 35 n=6 n=6 NNP cord-015021-pol2qm74 8509 36 ) ) -RRB- cord-015021-pol2qm74 8509 37 and and CC cord-015021-pol2qm74 8509 38 the the DT cord-015021-pol2qm74 8509 39 combination combination NN cord-015021-pol2qm74 8509 40 of of IN cord-015021-pol2qm74 8509 41 immunogiobulins immunogiobulin NNS cord-015021-pol2qm74 8509 42 , , , cord-015021-pol2qm74 8509 43 WEB web NN cord-015021-pol2qm74 8509 44 2086 2086 CD cord-015021-pol2qm74 8509 45 and and CC cord-015021-pol2qm74 8509 46 diclofenac diclofenac NNP cord-015021-pol2qm74 8509 47 ( ( -LRB- cord-015021-pol2qm74 8509 48 n=6 n=6 NNP cord-015021-pol2qm74 8509 49 ) ) -RRB- cord-015021-pol2qm74 8509 50 . . . cord-015021-pol2qm74 8510 1 Six six CD cord-015021-pol2qm74 8510 2 experiments experiment NNS cord-015021-pol2qm74 8510 3 without without IN cord-015021-pol2qm74 8510 4 toxin toxin NN cord-015021-pol2qm74 8510 5 served serve VBD cord-015021-pol2qm74 8510 6 as as IN cord-015021-pol2qm74 8510 7 controls control NNS cord-015021-pol2qm74 8510 8 . . . cord-015021-pol2qm74 8511 1 The the DT cord-015021-pol2qm74 8511 2 arterial arterial JJ cord-015021-pol2qm74 8511 3 pressure pressure NN cord-015021-pol2qm74 8511 4 mad mad VBP cord-015021-pol2qm74 8511 5 the the DT cord-015021-pol2qm74 8511 6 weight weight NN cord-015021-pol2qm74 8511 7 gain gain NN cord-015021-pol2qm74 8511 8 as as IN cord-015021-pol2qm74 8511 9 an an DT cord-015021-pol2qm74 8511 10 indicator indicator NN cord-015021-pol2qm74 8511 11 of of IN cord-015021-pol2qm74 8511 12 edema edema NN cord-015021-pol2qm74 8511 13 formation formation NN cord-015021-pol2qm74 8511 14 were be VBD cord-015021-pol2qm74 8511 15 continuously continuously RB cord-015021-pol2qm74 8511 16 monitored monitor VBN cord-015021-pol2qm74 8511 17 during during IN cord-015021-pol2qm74 8511 18 the the DT cord-015021-pol2qm74 8511 19 three three CD cord-015021-pol2qm74 8511 20 hour hour NN cord-015021-pol2qm74 8511 21 peffusion peffusion NN cord-015021-pol2qm74 8511 22 phase phase NN cord-015021-pol2qm74 8511 23 . . . cord-015021-pol2qm74 8512 1 Arachidonic arachidonic JJ cord-015021-pol2qm74 8512 2 - - HYPH cord-015021-pol2qm74 8512 3 ucid ucid JJ cord-015021-pol2qm74 8512 4 metabolites metabolite NNS cord-015021-pol2qm74 8512 5 , , , cord-015021-pol2qm74 8512 6 as as RB cord-015021-pol2qm74 8512 7 well well RB cord-015021-pol2qm74 8512 8 as as IN cord-015021-pol2qm74 8512 9 lactate lactate NN cord-015021-pol2qm74 8512 10 dehydrogenase dehydrogenase NN cord-015021-pol2qm74 8512 11 ( ( -LRB- cord-015021-pol2qm74 8512 12 LDH LDH NNP cord-015021-pol2qm74 8512 13 ) ) -RRB- cord-015021-pol2qm74 8512 14 and and CC cord-015021-pol2qm74 8512 15 K K NNP cord-015021-pol2qm74 8512 16 + + CC cord-015021-pol2qm74 8512 17 concentrations concentration NNS cord-015021-pol2qm74 8512 18 were be VBD cord-015021-pol2qm74 8512 19 determined determine VBN cord-015021-pol2qm74 8512 20 at at IN cord-015021-pol2qm74 8512 21 30 30 CD cord-015021-pol2qm74 8512 22 rain rain NN cord-015021-pol2qm74 8512 23 intervals interval NNS cord-015021-pol2qm74 8512 24 . . . cord-015021-pol2qm74 8513 1 Results result NNS cord-015021-pol2qm74 8513 2 : : : cord-015021-pol2qm74 8514 1 Cytotoxin Cytotoxin NNP cord-015021-pol2qm74 8514 2 caused cause VBD cord-015021-pol2qm74 8514 3 a a DT cord-015021-pol2qm74 8514 4 gradual gradual JJ cord-015021-pol2qm74 8514 5 increase increase NN cord-015021-pol2qm74 8514 6 in in IN cord-015021-pol2qm74 8514 7 pulmonary pulmonary JJ cord-015021-pol2qm74 8514 8 arterial arterial JJ cord-015021-pol2qm74 8514 9 pressure pressure NN cord-015021-pol2qm74 8514 10 , , , cord-015021-pol2qm74 8514 11 reaching reach VBG cord-015021-pol2qm74 8514 12 a a DT cord-015021-pol2qm74 8514 13 maximum maximum JJ cord-015021-pol2qm74 8514 14 value value NN cord-015021-pol2qm74 8514 15 of of IN cord-015021-pol2qm74 8514 16 2.5 2.5 CD cord-015021-pol2qm74 8514 17 times time NNS cord-015021-pol2qm74 8514 18 higher high JJR cord-015021-pol2qm74 8514 19 than than IN cord-015021-pol2qm74 8514 20 the the DT cord-015021-pol2qm74 8514 21 control control NN cord-015021-pol2qm74 8514 22 , , , cord-015021-pol2qm74 8514 23 starting start VBG cord-015021-pol2qm74 8514 24 after after IN cord-015021-pol2qm74 8514 25 1 1 CD cord-015021-pol2qm74 8514 26 min min NN cord-015021-pol2qm74 8514 27 and and CC cord-015021-pol2qm74 8514 28 a a DT cord-015021-pol2qm74 8514 29 delayed delay VBN cord-015021-pol2qm74 8514 30 onset onset NN cord-015021-pol2qm74 8514 31 of of IN cord-015021-pol2qm74 8514 32 edema edema NN cord-015021-pol2qm74 8514 33 formation formation NN cord-015021-pol2qm74 8514 34 resulting result VBG cord-015021-pol2qm74 8514 35 in in IN cord-015021-pol2qm74 8514 36 a a DT cord-015021-pol2qm74 8514 37 mean mean JJ cord-015021-pol2qm74 8514 38 weight weight NN cord-015021-pol2qm74 8514 39 gain gain NN cord-015021-pol2qm74 8514 40 of of IN cord-015021-pol2qm74 8514 41 20 20 CD cord-015021-pol2qm74 8514 42 g g NN cord-015021-pol2qm74 8514 43 after after IN cord-015021-pol2qm74 8514 44 120 120 CD cord-015021-pol2qm74 8514 45 min min NN cord-015021-pol2qm74 8514 46 . . . cord-015021-pol2qm74 8515 1 This this DT cord-015021-pol2qm74 8515 2 was be VBD cord-015021-pol2qm74 8515 3 paralleled parallel VBN cord-015021-pol2qm74 8515 4 by by IN cord-015021-pol2qm74 8515 5 a a DT cord-015021-pol2qm74 8515 6 significant significant JJ cord-015021-pol2qm74 8515 7 increase increase NN cord-015021-pol2qm74 8515 8 in in IN cord-015021-pol2qm74 8515 9 prostacyclin prostacyclin JJ cord-015021-pol2qm74 8515 10 generation generation NN cord-015021-pol2qm74 8515 11 and and CC cord-015021-pol2qm74 8515 12 a a DT cord-015021-pol2qm74 8515 13 continuous continuous JJ cord-015021-pol2qm74 8515 14 release release NN cord-015021-pol2qm74 8515 15 of of IN cord-015021-pol2qm74 8515 16 K k NN cord-015021-pol2qm74 8515 17 + + CC cord-015021-pol2qm74 8515 18 and and CC cord-015021-pol2qm74 8515 19 LDH LDH NNP cord-015021-pol2qm74 8515 20 . . . cord-015021-pol2qm74 8516 1 Thromboxane Thromboxane NNP cord-015021-pol2qm74 8516 2 synthesis synthesis NN cord-015021-pol2qm74 8516 3 exceeded exceed VBD cord-015021-pol2qm74 8516 4 about about RB cord-015021-pol2qm74 8516 5 10 10 CD cord-015021-pol2qm74 8516 6 times time NNS cord-015021-pol2qm74 8516 7 that that DT cord-015021-pol2qm74 8516 8 of of IN cord-015021-pol2qm74 8516 9 controls control NNS cord-015021-pol2qm74 8516 10 in in IN cord-015021-pol2qm74 8516 11 the the DT cord-015021-pol2qm74 8516 12 toxin toxin NN cord-015021-pol2qm74 8516 13 treated treat VBD cord-015021-pol2qm74 8516 14 lungs lung NNS cord-015021-pol2qm74 8516 15 . . . cord-015021-pol2qm74 8517 1 Pretreatment pretreatment NN cord-015021-pol2qm74 8517 2 with with IN cord-015021-pol2qm74 8517 3 WEB web NN cord-015021-pol2qm74 8517 4 2086 2086 CD cord-015021-pol2qm74 8517 5 or or CC cord-015021-pol2qm74 8517 6 diclofenac diclofenac NN cord-015021-pol2qm74 8517 7 significantly significantly RB cord-015021-pol2qm74 8517 8 attenuated attenuate VBD cord-015021-pol2qm74 8517 9 the the DT cord-015021-pol2qm74 8517 10 pressure pressure NN cord-015021-pol2qm74 8517 11 response response NN cord-015021-pol2qm74 8517 12 and and CC cord-015021-pol2qm74 8517 13 edema edema NN cord-015021-pol2qm74 8517 14 formation formation NN cord-015021-pol2qm74 8517 15 evoked evoke VBN cord-015021-pol2qm74 8517 16 by by IN cord-015021-pol2qm74 8517 17 cytotoxin cytotoxin NNP cord-015021-pol2qm74 8517 18 . . . cord-015021-pol2qm74 8518 1 The the DT cord-015021-pol2qm74 8518 2 addition addition NN cord-015021-pol2qm74 8518 3 of of IN cord-015021-pol2qm74 8518 4 the the DT cord-015021-pol2qm74 8518 5 unspecific unspecific JJ cord-015021-pol2qm74 8518 6 immunognbulin immunognbulin JJ cord-015021-pol2qm74 8518 7 preparation preparation NN cord-015021-pol2qm74 8518 8 alone alone RB cord-015021-pol2qm74 8518 9 induced induce VBD cord-015021-pol2qm74 8518 10 a a DT cord-015021-pol2qm74 8518 11 transient transient JJ cord-015021-pol2qm74 8518 12 pressure pressure NN cord-015021-pol2qm74 8518 13 increase increase NN cord-015021-pol2qm74 8518 14 within within IN cord-015021-pol2qm74 8518 15 the the DT cord-015021-pol2qm74 8518 16 first first JJ cord-015021-pol2qm74 8518 17 minutes minute NNS cord-015021-pol2qm74 8518 18 , , , cord-015021-pol2qm74 8518 19 but but CC cord-015021-pol2qm74 8518 20 mean mean JJ cord-015021-pol2qm74 8518 21 values value NNS cord-015021-pol2qm74 8518 22 remained remain VBD cord-015021-pol2qm74 8518 23 below below IN cord-015021-pol2qm74 8518 24 those those DT cord-015021-pol2qm74 8518 25 of of IN cord-015021-pol2qm74 8518 26 the the DT cord-015021-pol2qm74 8518 27 cytotoxin cytotoxin NNP cord-015021-pol2qm74 8518 28 group group NN cord-015021-pol2qm74 8518 29 in in IN cord-015021-pol2qm74 8518 30 the the DT cord-015021-pol2qm74 8518 31 continuing continue VBG cord-015021-pol2qm74 8518 32 observation observation NN cord-015021-pol2qm74 8518 33 period period NN cord-015021-pol2qm74 8518 34 . . . cord-015021-pol2qm74 8519 1 Mmost Mmost NNP cord-015021-pol2qm74 8519 2 complete complete JJ cord-015021-pol2qm74 8519 3 inhibition inhibition NN cord-015021-pol2qm74 8519 4 of of IN cord-015021-pol2qm74 8519 5 the the DT cord-015021-pol2qm74 8519 6 pressure pressure NN cord-015021-pol2qm74 8519 7 reaction reaction NN cord-015021-pol2qm74 8519 8 , , , cord-015021-pol2qm74 8519 9 the the DT cord-015021-pol2qm74 8519 10 edema edema NN cord-015021-pol2qm74 8519 11 formation formation NN cord-015021-pol2qm74 8519 12 and and CC cord-015021-pol2qm74 8519 13 the the DT cord-015021-pol2qm74 8519 14 metabolic metabolic JJ cord-015021-pol2qm74 8519 15 alterations alteration NNS cord-015021-pol2qm74 8519 16 was be VBD cord-015021-pol2qm74 8519 17 achieved achieve VBN cord-015021-pol2qm74 8519 18 mainly mainly RB cord-015021-pol2qm74 8519 19 by by IN cord-015021-pol2qm74 8519 20 the the DT cord-015021-pol2qm74 8519 21 combination combination NN cord-015021-pol2qm74 8519 22 of of IN cord-015021-pol2qm74 8519 23 immunoglobulin immunoglobulin NN cord-015021-pol2qm74 8519 24 , , , cord-015021-pol2qm74 8519 25 WEB web NN cord-015021-pol2qm74 8519 26 2086 2086 CD cord-015021-pol2qm74 8519 27 and and CC cord-015021-pol2qm74 8519 28 diclofenac diclofenac NN cord-015021-pol2qm74 8519 29 and and CC cord-015021-pol2qm74 8519 30 to to IN cord-015021-pol2qm74 8519 31 lesser less JJR cord-015021-pol2qm74 8519 32 extend extend VB cord-015021-pol2qm74 8519 33 by by IN cord-015021-pol2qm74 8519 34 the the DT cord-015021-pol2qm74 8519 35 specific specific JJ cord-015021-pol2qm74 8519 36 toxin toxin NN cord-015021-pol2qm74 8519 37 antibody antibody NN cord-015021-pol2qm74 8519 38 . . . cord-015021-pol2qm74 8520 1 Conclusion conclusion NN cord-015021-pol2qm74 8520 2 : : : cord-015021-pol2qm74 8521 1 The the DT cord-015021-pol2qm74 8521 2 current current JJ cord-015021-pol2qm74 8521 3 results result NNS cord-015021-pol2qm74 8521 4 point point NN cord-015021-pol2qm74 8521 5 towards towards IN cord-015021-pol2qm74 8521 6 the the DT cord-015021-pol2qm74 8521 7 crucial crucial JJ cord-015021-pol2qm74 8521 8 role role NN cord-015021-pol2qm74 8521 9 of of IN cord-015021-pol2qm74 8521 10 PAF PAF NNP cord-015021-pol2qm74 8521 11 and and CC cord-015021-pol2qm74 8521 12 AA AA NNP cord-015021-pol2qm74 8521 13 - - HYPH cord-015021-pol2qm74 8521 14 metabolites metabolite NNS cord-015021-pol2qm74 8521 15 as as IN cord-015021-pol2qm74 8521 16 mediators mediator NNS cord-015021-pol2qm74 8521 17 of of IN cord-015021-pol2qm74 8521 18 cytotoxin cytotoxin NNP cord-015021-pol2qm74 8521 19 induced induce VBD cord-015021-pol2qm74 8521 20 microvascular microvascular JJ cord-015021-pol2qm74 8521 21 injury injury NN cord-015021-pol2qm74 8521 22 . . . cord-015021-pol2qm74 8522 1 The the DT cord-015021-pol2qm74 8522 2 systemic systemic JJ cord-015021-pol2qm74 8522 3 or or CC cord-015021-pol2qm74 8522 4 local local JJ cord-015021-pol2qm74 8522 5 application application NN cord-015021-pol2qm74 8522 6 of of IN cord-015021-pol2qm74 8522 7 cytotoxin cytotoxin NNP cord-015021-pol2qm74 8522 8 antibodies antibody NNS cord-015021-pol2qm74 8522 9 or or CC cord-015021-pol2qm74 8522 10 even even RB cord-015021-pol2qm74 8522 11 unspecific unspecific JJ cord-015021-pol2qm74 8522 12 immunoglobolins immunoglobolin NNS cord-015021-pol2qm74 8522 13 in in IN cord-015021-pol2qm74 8522 14 combination combination NN cord-015021-pol2qm74 8522 15 with with IN cord-015021-pol2qm74 8522 16 PAF PAF NNP cord-015021-pol2qm74 8522 17 - - HYPH cord-015021-pol2qm74 8522 18 antagonist antagonist NN cord-015021-pol2qm74 8522 19 and and CC cord-015021-pol2qm74 8522 20 diclofenac diclofenac NN cord-015021-pol2qm74 8522 21 appears appear VBZ cord-015021-pol2qm74 8522 22 to to TO cord-015021-pol2qm74 8522 23 be be VB cord-015021-pol2qm74 8522 24 a a DT cord-015021-pol2qm74 8522 25 promising promising JJ cord-015021-pol2qm74 8522 26 therapeutic therapeutic JJ cord-015021-pol2qm74 8522 27 approach approach NN cord-015021-pol2qm74 8522 28 in in IN cord-015021-pol2qm74 8522 29 the the DT cord-015021-pol2qm74 8522 30 case case NN cord-015021-pol2qm74 8522 31 of of IN cord-015021-pol2qm74 8522 32 infection infection NN cord-015021-pol2qm74 8522 33 with with IN cord-015021-pol2qm74 8522 34 cytotoxin cytotoxin NN cord-015021-pol2qm74 8522 35 - - HYPH cord-015021-pol2qm74 8522 36 preducing preduce VBG cord-015021-pol2qm74 8522 37 strains strain NNS cord-015021-pol2qm74 8522 38 . . . cord-015021-pol2qm74 8523 1 Cytokines cytokine NNS cord-015021-pol2qm74 8523 2 have have VBP cord-015021-pol2qm74 8523 3 long long RB cord-015021-pol2qm74 8523 4 been be VBN cord-015021-pol2qm74 8523 5 shown show VBN cord-015021-pol2qm74 8523 6 to to TO cord-015021-pol2qm74 8523 7 be be VB cord-015021-pol2qm74 8523 8 of of IN cord-015021-pol2qm74 8523 9 particular particular JJ cord-015021-pol2qm74 8523 10 importance importance NN cord-015021-pol2qm74 8523 11 in in IN cord-015021-pol2qm74 8523 12 the the DT cord-015021-pol2qm74 8523 13 metabolic metabolic JJ cord-015021-pol2qm74 8523 14 derangements derangement NNS cord-015021-pol2qm74 8523 15 occurring occur VBG cord-015021-pol2qm74 8523 16 in in IN cord-015021-pol2qm74 8523 17 LPS LPS NNP cord-015021-pol2qm74 8523 18 - - HYPH cord-015021-pol2qm74 8523 19 induced induce VBN cord-015021-pol2qm74 8523 20 shock shock NN cord-015021-pol2qm74 8523 21 . . . cord-015021-pol2qm74 8524 1 Recent recent JJ cord-015021-pol2qm74 8524 2 studies study NNS cord-015021-pol2qm74 8524 3 strongly strongly RB cord-015021-pol2qm74 8524 4 imply imply VBP cord-015021-pol2qm74 8524 5 the the DT cord-015021-pol2qm74 8524 6 involvement involvement NN cord-015021-pol2qm74 8524 7 of of IN cord-015021-pol2qm74 8524 8 Platelet platelet NN cord-015021-pol2qm74 8524 9 Aggregating Aggregating NNP cord-015021-pol2qm74 8524 10 Factor Factor NNP cord-015021-pol2qm74 8524 11 ( ( -LRB- cord-015021-pol2qm74 8524 12 PAF PAF NNP cord-015021-pol2qm74 8524 13 ) ) -RRB- cord-015021-pol2qm74 8524 14 in in IN cord-015021-pol2qm74 8524 15 the the DT cord-015021-pol2qm74 8524 16 pathogenesis pathogenesis NN cord-015021-pol2qm74 8524 17 of of IN cord-015021-pol2qm74 8524 18 Gram gram NN cord-015021-pol2qm74 8524 19 - - HYPH cord-015021-pol2qm74 8524 20 negative negative JJ cord-015021-pol2qm74 8524 21 bacterial bacterial JJ cord-015021-pol2qm74 8524 22 sepsis sepsis NN cord-015021-pol2qm74 8524 23 . . . cord-015021-pol2qm74 8525 1 An an DT cord-015021-pol2qm74 8525 2 autocatalytic autocatalytic JJ cord-015021-pol2qm74 8525 3 feedback feedback NN cord-015021-pol2qm74 8525 4 network network NN cord-015021-pol2qm74 8525 5 has have VBZ cord-015021-pol2qm74 8525 6 been be VBN cord-015021-pol2qm74 8525 7 postulated postulate VBN cord-015021-pol2qm74 8525 8 to to TO cord-015021-pol2qm74 8525 9 exist exist VB cord-015021-pol2qm74 8525 10 between between IN cord-015021-pol2qm74 8525 11 PAF PAF NNP cord-015021-pol2qm74 8525 12 and and CC cord-015021-pol2qm74 8525 13 Tumor Tumor NNP cord-015021-pol2qm74 8525 14 Necrosis necrosis NN cord-015021-pol2qm74 8525 15 Factor factor NN cord-015021-pol2qm74 8525 16 ( ( -LRB- cord-015021-pol2qm74 8525 17 TNF TNF NNP cord-015021-pol2qm74 8525 18 ) ) -RRB- cord-015021-pol2qm74 8525 19 , , , cord-015021-pol2qm74 8525 20 a a DT cord-015021-pol2qm74 8525 21 key key JJ cord-015021-pol2qm74 8525 22 cytokine cytokine NN cord-015021-pol2qm74 8525 23 involved involve VBN cord-015021-pol2qm74 8525 24 in in IN cord-015021-pol2qm74 8525 25 septic septic JJ cord-015021-pol2qm74 8525 26 metabolic metabolic JJ cord-015021-pol2qm74 8525 27 cascade cascade NN cord-015021-pol2qm74 8525 28 , , , cord-015021-pol2qm74 8525 29 leading lead VBG cord-015021-pol2qm74 8525 30 to to IN cord-015021-pol2qm74 8525 31 an an DT cord-015021-pol2qm74 8525 32 uncontrolled uncontrolled JJ cord-015021-pol2qm74 8525 33 amplification amplification NN cord-015021-pol2qm74 8525 34 of of IN cord-015021-pol2qm74 8525 35 inflammatory inflammatory JJ cord-015021-pol2qm74 8525 36 mediator mediator NN cord-015021-pol2qm74 8525 37 release release NN cord-015021-pol2qm74 8525 38 . . . cord-015021-pol2qm74 8526 1 We -PRON- PRP cord-015021-pol2qm74 8526 2 have have VBP cord-015021-pol2qm74 8526 3 previously previously RB cord-015021-pol2qm74 8526 4 shown show VBN cord-015021-pol2qm74 8526 5 that that IN cord-015021-pol2qm74 8526 6 ST ST NNP cord-015021-pol2qm74 8526 7 899 899 CD cord-015021-pol2qm74 8527 1 ( ( -LRB- cord-015021-pol2qm74 8527 2 4-N 4-n CD cord-015021-pol2qm74 8527 3 , , , cord-015021-pol2qm74 8527 4 N n CD cord-015021-pol2qm74 8527 5 , , , cord-015021-pol2qm74 8527 6 N N NNP cord-015021-pol2qm74 8527 7 trimethylammonium-(R)-3-isovaleroyloxy trimethylammonium-(R)-3-isovaleroyloxy NNP cord-015021-pol2qm74 8527 8 - - HYPH cord-015021-pol2qm74 8527 9 butanoic butanoic NNP cord-015021-pol2qm74 8527 10 acid acid NNP cord-015021-pol2qm74 8527 11 Z-3-(5-chlorphtalidiliden Z-3-(5-chlorphtalidiliden NNP cord-015021-pol2qm74 8527 12 ) ) -RRB- cord-015021-pol2qm74 8528 1 ethyl ethyl NNP cord-015021-pol2qm74 8528 2 ester ester NNP cord-015021-pol2qm74 8528 3 bromide bromide NN cord-015021-pol2qm74 8528 4 ) ) -RRB- cord-015021-pol2qm74 8528 5 was be VBD cord-015021-pol2qm74 8528 6 quite quite RB cord-015021-pol2qm74 8528 7 effective effective JJ cord-015021-pol2qm74 8528 8 in in IN cord-015021-pol2qm74 8528 9 inhibiting inhibit VBG cord-015021-pol2qm74 8528 10 the the DT cord-015021-pol2qm74 8528 11 " " `` cord-015021-pol2qm74 8528 12 in in FW cord-015021-pol2qm74 8528 13 vitro vitro FW cord-015021-pol2qm74 8528 14 " " '' cord-015021-pol2qm74 8528 15 binding bind VBG cord-015021-pol2qm74 8528 16 of of IN cord-015021-pol2qm74 8528 17 3H 3h CD cord-015021-pol2qm74 8528 18 - - HYPH cord-015021-pol2qm74 8528 19 PAF PAF NNP cord-015021-pol2qm74 8528 20 ( ( -LRB- cord-015021-pol2qm74 8528 21 Ki=7.5x10 Ki=7.5x10 NNP cord-015021-pol2qm74 8528 22 -8 -8 NNP cord-015021-pol2qm74 8528 23 M M NNP cord-015021-pol2qm74 8528 24 ) ) -RRB- cord-015021-pol2qm74 8528 25 to to IN cord-015021-pol2qm74 8528 26 rabbit rabbit NN cord-015021-pol2qm74 8528 27 platelets platelet NNS cord-015021-pol2qm74 8528 28 . . . cord-015021-pol2qm74 8529 1 The the DT cord-015021-pol2qm74 8529 2 present present JJ cord-015021-pol2qm74 8529 3 study study NN cord-015021-pol2qm74 8529 4 shows show VBZ cord-015021-pol2qm74 8529 5 that that IN cord-015021-pol2qm74 8529 6 pretreatment pretreatment NN cord-015021-pol2qm74 8529 7 of of IN cord-015021-pol2qm74 8529 8 C57BL/6 C57BL/6 NNP cord-015021-pol2qm74 8529 9 mice mouse NNS cord-015021-pol2qm74 8529 10 with with IN cord-015021-pol2qm74 8529 11 ST ST NNP cord-015021-pol2qm74 8529 12 899 899 CD cord-015021-pol2qm74 8529 13 , , , cord-015021-pol2qm74 8529 14 administered administer VBN cord-015021-pol2qm74 8529 15 by by IN cord-015021-pol2qm74 8529 16 different different JJ cord-015021-pol2qm74 8529 17 routes route NNS cord-015021-pol2qm74 8529 18 , , , cord-015021-pol2qm74 8529 19 dose dose NN cord-015021-pol2qm74 8529 20 - - HYPH cord-015021-pol2qm74 8529 21 dependently dependently RB cord-015021-pol2qm74 8529 22 and and CC cord-015021-pol2qm74 8529 23 significantly significantly RB cord-015021-pol2qm74 8529 24 reduces reduce VBZ cord-015021-pol2qm74 8529 25 the the DT cord-015021-pol2qm74 8529 26 lethality lethality NN cord-015021-pol2qm74 8529 27 induced induce VBN cord-015021-pol2qm74 8529 28 by by IN cord-015021-pol2qm74 8529 29 endotoxin endotoxin NN cord-015021-pol2qm74 8529 30 ( ( -LRB- cord-015021-pol2qm74 8529 31 E.coli E.coli NNS cord-015021-pol2qm74 8529 32 055 055 CD cord-015021-pol2qm74 8529 33 : : : cord-015021-pol2qm74 8529 34 B5 b5 NN cord-015021-pol2qm74 8529 35 injected inject VBD cord-015021-pol2qm74 8529 36 at at IN cord-015021-pol2qm74 8529 37 30 30 CD cord-015021-pol2qm74 8529 38 mg mg NN cord-015021-pol2qm74 8529 39 / / SYM cord-015021-pol2qm74 8529 40 kg kg NNP cord-015021-pol2qm74 8529 41 intraperitoneally intraperitoneally NN cord-015021-pol2qm74 8529 42 ) ) -RRB- cord-015021-pol2qm74 8529 43 . . . cord-015021-pol2qm74 8530 1 Very very RB cord-015021-pol2qm74 8530 2 interestingly interestingly RB cord-015021-pol2qm74 8530 3 , , , cord-015021-pol2qm74 8530 4 ST ST NNP cord-015021-pol2qm74 8530 5 899 899 CD cord-015021-pol2qm74 8530 6 administered administer VBD cord-015021-pol2qm74 8530 7 at at IN cord-015021-pol2qm74 8530 8 the the DT cord-015021-pol2qm74 8530 9 same same JJ cord-015021-pol2qm74 8530 10 doses dose NNS cord-015021-pol2qm74 8530 11 as as IN cord-015021-pol2qm74 8530 12 above above RB cord-015021-pol2qm74 8530 13 ( ( -LRB- cord-015021-pol2qm74 8530 14 i.e. i.e. FW cord-015021-pol2qm74 8530 15 1.25 1.25 CD cord-015021-pol2qm74 8530 16 , , , cord-015021-pol2qm74 8530 17 2.5 2.5 CD cord-015021-pol2qm74 8530 18 , , , cord-015021-pol2qm74 8530 19 and and CC cord-015021-pol2qm74 8530 20 5 5 CD cord-015021-pol2qm74 8530 21 mg mg NNP cord-015021-pol2qm74 8530 22 / / SYM cord-015021-pol2qm74 8530 23 kg kg NN cord-015021-pol2qm74 8530 24 body body NN cord-015021-pol2qm74 8530 25 weight weight NN cord-015021-pol2qm74 8530 26 ) ) -RRB- cord-015021-pol2qm74 8530 27 results result NNS cord-015021-pol2qm74 8530 28 to to TO cord-015021-pol2qm74 8530 29 be be VB cord-015021-pol2qm74 8530 30 significantly significantly RB cord-015021-pol2qm74 8530 31 effective effective JJ cord-015021-pol2qm74 8530 32 in in IN cord-015021-pol2qm74 8530 33 reducing reduce VBG cord-015021-pol2qm74 8530 34 the the DT cord-015021-pol2qm74 8530 35 endotoxin endotoxin NN cord-015021-pol2qm74 8530 36 - - HYPH cord-015021-pol2qm74 8530 37 induced induce VBN cord-015021-pol2qm74 8530 38 release release NN cord-015021-pol2qm74 8530 39 of of IN cord-015021-pol2qm74 8530 40 serum serum NN cord-015021-pol2qm74 8530 41 TNF TNF NNP cord-015021-pol2qm74 8530 42 . . . cord-015021-pol2qm74 8531 1 The the DT cord-015021-pol2qm74 8531 2 reported report VBN cord-015021-pol2qm74 8531 3 dual dual JJ cord-015021-pol2qm74 8531 4 activity activity NN cord-015021-pol2qm74 8531 5 of of IN cord-015021-pol2qm74 8531 6 ST ST NNP cord-015021-pol2qm74 8531 7 899 899 CD cord-015021-pol2qm74 8531 8 ( ( -LRB- cord-015021-pol2qm74 8531 9 i.e. i.e. FW cord-015021-pol2qm74 8531 10 PAF PAF NNP cord-015021-pol2qm74 8531 11 antagonism antagonism NN cord-015021-pol2qm74 8531 12 and and CC cord-015021-pol2qm74 8531 13 decreased decrease VBD cord-015021-pol2qm74 8531 14 circulating circulate VBG cord-015021-pol2qm74 8531 15 TNF TNF NNP cord-015021-pol2qm74 8531 16 levels level NNS cord-015021-pol2qm74 8531 17 ) ) -RRB- cord-015021-pol2qm74 8531 18 may may MD cord-015021-pol2qm74 8531 19 turn turn VB cord-015021-pol2qm74 8531 20 out out RP cord-015021-pol2qm74 8531 21 to to TO cord-015021-pol2qm74 8531 22 be be VB cord-015021-pol2qm74 8531 23 greatly greatly RB cord-015021-pol2qm74 8531 24 beneficial beneficial JJ cord-015021-pol2qm74 8531 25 , , , cord-015021-pol2qm74 8531 26 in in IN cord-015021-pol2qm74 8531 27 combination combination NN cord-015021-pol2qm74 8531 28 with with IN cord-015021-pol2qm74 8531 29 current current JJ cord-015021-pol2qm74 8531 30 therapies therapy NNS cord-015021-pol2qm74 8531 31 , , , cord-015021-pol2qm74 8531 32 in in IN cord-015021-pol2qm74 8531 33 the the DT cord-015021-pol2qm74 8531 34 treatment treatment NN cord-015021-pol2qm74 8531 35 of of IN cord-015021-pol2qm74 8531 36 diseases disease NNS cord-015021-pol2qm74 8531 37 that that WDT cord-015021-pol2qm74 8531 38 involve involve VBP cord-015021-pol2qm74 8531 39 overproduction overproduction NN cord-015021-pol2qm74 8531 40 of of IN cord-015021-pol2qm74 8531 41 TNF TNF NNP cord-015021-pol2qm74 8531 42 and and CC cord-015021-pol2qm74 8531 43 PAF PAF NNP cord-015021-pol2qm74 8531 44 such such JJ cord-015021-pol2qm74 8531 45 as as IN cord-015021-pol2qm74 8531 46 septic septic JJ cord-015021-pol2qm74 8531 47 shock shock NN cord-015021-pol2qm74 8531 48 . . . cord-015021-pol2qm74 8532 1 Introduction introduction NN cord-015021-pol2qm74 8532 2 : : : cord-015021-pol2qm74 8532 3 Recently recently RB cord-015021-pol2qm74 8532 4 , , , cord-015021-pol2qm74 8532 5 we -PRON- PRP cord-015021-pol2qm74 8532 6 reported report VBD cord-015021-pol2qm74 8532 7 that that IN cord-015021-pol2qm74 8532 8 prophylactic prophylactic JJ cord-015021-pol2qm74 8532 9 whole whole JJ cord-015021-pol2qm74 8532 10 body body NN cord-015021-pol2qm74 8532 11 hyperthermia hyperthermia NN cord-015021-pol2qm74 8532 12 ( ( -LRB- cord-015021-pol2qm74 8532 13 42.5 42.5 CD cord-015021-pol2qm74 8532 14 ° ° NN cord-015021-pol2qm74 8532 15 C C NNP cord-015021-pol2qm74 8532 16 ) ) -RRB- cord-015021-pol2qm74 8532 17 induces induce VBZ cord-015021-pol2qm74 8532 18 heat heat NN cord-015021-pol2qm74 8532 19 shock shock NN cord-015021-pol2qm74 8532 20 protein protein NN cord-015021-pol2qm74 8532 21 ( ( -LRB- cord-015021-pol2qm74 8532 22 ' ' `` cord-015021-pol2qm74 8532 23 ASP ASP NNP cord-015021-pol2qm74 8532 24 ) ) -RRB- cord-015021-pol2qm74 8532 25 72 72 CD cord-015021-pol2qm74 8532 26 and and CC cord-015021-pol2qm74 8532 27 increases increase VBZ cord-015021-pol2qm74 8532 28 smvival smvival NNP cord-015021-pol2qm74 8532 29 2 2 CD cord-015021-pol2qm74 8532 30 - - SYM cord-015021-pol2qm74 8532 31 4 4 CD cord-015021-pol2qm74 8532 32 fold fold VBP cord-015021-pol2qm74 8532 33 in in IN cord-015021-pol2qm74 8532 34 a a DT cord-015021-pol2qm74 8532 35 mouse mouse NN cord-015021-pol2qm74 8532 36 endotoxin endotoxin NN cord-015021-pol2qm74 8532 37 model model NN cord-015021-pol2qm74 8532 38 ( ( -LRB- cord-015021-pol2qm74 8532 39 Am am NN cord-015021-pol2qm74 8532 40 . . . cord-015021-pol2qm74 8533 1 J. J. NNP cord-015021-pol2qm74 8533 2 Physiol Physiol NNP cord-015021-pol2qm74 8533 3 . . . cord-015021-pol2qm74 8534 1 in in IN cord-015021-pol2qm74 8534 2 press press NN cord-015021-pol2qm74 8534 3 ) ) -RRB- cord-015021-pol2qm74 8534 4 . . . cord-015021-pol2qm74 8535 1 Other other JJ cord-015021-pol2qm74 8535 2 investigators investigator NNS cord-015021-pol2qm74 8535 3 reported report VBD cord-015021-pol2qm74 8535 4 that that IN cord-015021-pol2qm74 8535 5 prophylactic prophylactic JJ cord-015021-pol2qm74 8535 6 pharmacologic pharmacologic JJ cord-015021-pol2qm74 8535 7 induction induction NN cord-015021-pol2qm74 8535 8 of of IN cord-015021-pol2qm74 8535 9 HSP-72 HSP-72 NNP cord-015021-pol2qm74 8535 10 by by IN cord-015021-pol2qm74 8535 11 sodium sodium NN cord-015021-pol2qm74 8535 12 arsenite arsenite NNP cord-015021-pol2qm74 8535 13 improves improve VBZ cord-015021-pol2qm74 8535 14 survival survival NN cord-015021-pol2qm74 8535 15 in in IN cord-015021-pol2qm74 8535 16 a a DT cord-015021-pol2qm74 8535 17 rat rat NN cord-015021-pol2qm74 8535 18 sepsis sepsis NN cord-015021-pol2qm74 8535 19 model model NN cord-015021-pol2qm74 8535 20 ( ( -LRB- cord-015021-pol2qm74 8535 21 abstract abstract JJ cord-015021-pol2qm74 8535 22 A95 A95 NNP cord-015021-pol2qm74 8535 23 Am Am NNP cord-015021-pol2qm74 8535 24 . . . cord-015021-pol2qm74 8536 1 Rev. Rev. NNP cord-015021-pol2qm74 8536 2 Resp Resp NNP cord-015021-pol2qm74 8536 3 . . . cord-015021-pol2qm74 8537 1 Dis Dis NNP cord-015021-pol2qm74 8537 2 . . NNP cord-015021-pol2qm74 8537 3 Vol Vol NNP cord-015021-pol2qm74 8537 4 . . . cord-015021-pol2qm74 8538 1 147 147 CD cord-015021-pol2qm74 8538 2 , , , cord-015021-pol2qm74 8538 3 1993 1993 CD cord-015021-pol2qm74 8538 4 ) ) -RRB- cord-015021-pol2qm74 8538 5 . . . cord-015021-pol2qm74 8539 1 The the DT cord-015021-pol2qm74 8539 2 effects effect NNS cord-015021-pol2qm74 8539 3 of of IN cord-015021-pol2qm74 8539 4 heat heat NN cord-015021-pol2qm74 8539 5 are be VBP cord-015021-pol2qm74 8539 6 complex complex JJ cord-015021-pol2qm74 8539 7 and and CC cord-015021-pol2qm74 8539 8 in in IN cord-015021-pol2qm74 8539 9 addition addition NN cord-015021-pol2qm74 8539 10 to to IN cord-015021-pol2qm74 8539 11 formation formation NN cord-015021-pol2qm74 8539 12 of of IN cord-015021-pol2qm74 8539 13 liSP-72 liSP-72 NNP cord-015021-pol2qm74 8539 14 include include VB cord-015021-pol2qm74 8539 15 release release NN cord-015021-pol2qm74 8539 16 of of IN cord-015021-pol2qm74 8539 17 cytokines cytokine NNS cord-015021-pol2qm74 8539 18 , , , cord-015021-pol2qm74 8539 19 changes change NNS cord-015021-pol2qm74 8539 20 in in IN cord-015021-pol2qm74 8539 21 cellular cellular JJ cord-015021-pol2qm74 8539 22 pH ph NN cord-015021-pol2qm74 8539 23 etc etc FW cord-015021-pol2qm74 8539 24 . . . cord-015021-pol2qm74 8540 1 Thus thus RB cord-015021-pol2qm74 8540 2 , , , cord-015021-pol2qm74 8540 3 the the DT cord-015021-pol2qm74 8540 4 protective protective JJ cord-015021-pol2qm74 8540 5 mechanisms mechanism NNS cord-015021-pol2qm74 8540 6 of of IN cord-015021-pol2qm74 8540 7 heat heat NN cord-015021-pol2qm74 8540 8 may may MD cord-015021-pol2qm74 8540 9 differ differ VB cord-015021-pol2qm74 8540 10 from from IN cord-015021-pol2qm74 8540 11 those those DT cord-015021-pol2qm74 8540 12 due due JJ cord-015021-pol2qm74 8540 13 to to IN cord-015021-pol2qm74 8540 14 pharmacologically pharmacologically RB cord-015021-pol2qm74 8540 15 induced induce VBN cord-015021-pol2qm74 8540 16 . . . cord-015021-pol2qm74 8541 1 The the DT cord-015021-pol2qm74 8541 2 purpose purpose NN cord-015021-pol2qm74 8541 3 of of IN cord-015021-pol2qm74 8541 4 this this DT cord-015021-pol2qm74 8541 5 study study NN cord-015021-pol2qm74 8541 6 was be VBD cord-015021-pol2qm74 8541 7 to to TO cord-015021-pol2qm74 8541 8 compare compare VB cord-015021-pol2qm74 8541 9 the the DT cord-015021-pol2qm74 8541 10 protection protection NN cord-015021-pol2qm74 8541 11 of of IN cord-015021-pol2qm74 8541 12 heat heat NN cord-015021-pol2qm74 8541 13 vs vs IN cord-015021-pol2qm74 8541 14 the the DT cord-015021-pol2qm74 8541 15 protection protection NN cord-015021-pol2qm74 8541 16 of of IN cord-015021-pol2qm74 8541 17 pharmacologically pharmacologically RB cord-015021-pol2qm74 8541 18 induced induce VBN cord-015021-pol2qm74 8541 19 HSP-72 HSP-72 NNP cord-015021-pol2qm74 8541 20 in in IN cord-015021-pol2qm74 8541 21 a a DT cord-015021-pol2qm74 8541 22 mouse mouse NN cord-015021-pol2qm74 8541 23 endotoxin endotoxin NN cord-015021-pol2qm74 8541 24 model model NN cord-015021-pol2qm74 8541 25 to to TO cord-015021-pol2qm74 8541 26 determine determine VB cord-015021-pol2qm74 8541 27 if if IN cord-015021-pol2qm74 8541 28 different different JJ cord-015021-pol2qm74 8541 29 protective protective JJ cord-015021-pol2qm74 8541 30 mechanisms mechanism NNS cord-015021-pol2qm74 8541 31 were be VBD cord-015021-pol2qm74 8541 32 likely likely JJ cord-015021-pol2qm74 8541 33 to to TO cord-015021-pol2qm74 8541 34 be be VB cord-015021-pol2qm74 8541 35 involved involve VBN cord-015021-pol2qm74 8541 36 .. .. . cord-015021-pol2qm74 8542 1 i%'lethods i%'lethods NNP cord-015021-pol2qm74 8542 2 : : : cord-015021-pol2qm74 8542 3 Both both DT cord-015021-pol2qm74 8542 4 sodium sodium NN cord-015021-pol2qm74 8542 5 arsenite arsenite JJ cord-015021-pol2qm74 8542 6 ( ( -LRB- cord-015021-pol2qm74 8542 7 10 10 CD cord-015021-pol2qm74 8542 8 mg mg NNP cord-015021-pol2qm74 8542 9 / / SYM cord-015021-pol2qm74 8542 10 kg kg NNP cord-015021-pol2qm74 8542 11 ) ) -RRB- cord-015021-pol2qm74 8542 12 and and CC cord-015021-pol2qm74 8542 13 ethanol ethanol NN cord-015021-pol2qm74 8542 14 ( ( -LRB- cord-015021-pol2qm74 8542 15 400 400 CD cord-015021-pol2qm74 8542 16 ~1 ~1 CD cord-015021-pol2qm74 8542 17 of of IN cord-015021-pol2qm74 8542 18 39 39 CD cord-015021-pol2qm74 8542 19 % % NN cord-015021-pol2qm74 8542 20 ethanol ethanol NN cord-015021-pol2qm74 8542 21 ) ) -RRB- cord-015021-pol2qm74 8542 22 caused cause VBD cord-015021-pol2qm74 8542 23 marked mark VBN cord-015021-pol2qm74 8542 24 induction induction NN cord-015021-pol2qm74 8542 25 of of IN cord-015021-pol2qm74 8542 26 HSP-72 HSP-72 NNP cord-015021-pol2qm74 8542 27 in in IN cord-015021-pol2qm74 8542 28 lung lung NN cord-015021-pol2qm74 8542 29 , , , cord-015021-pol2qm74 8542 30 gut gut NN cord-015021-pol2qm74 8542 31 , , , cord-015021-pol2qm74 8542 32 kidney kidney NN cord-015021-pol2qm74 8542 33 , , , cord-015021-pol2qm74 8542 34 and and CC cord-015021-pol2qm74 8542 35 liver liver NN cord-015021-pol2qm74 8542 36 , , , cord-015021-pol2qm74 8542 37 which which WDT cord-015021-pol2qm74 8542 38 was be VBD cord-015021-pol2qm74 8542 39 comparable comparable JJ cord-015021-pol2qm74 8542 40 to to IN cord-015021-pol2qm74 8542 41 heat heat NN cord-015021-pol2qm74 8542 42 - - HYPH cord-015021-pol2qm74 8542 43 induced induce VBN cord-015021-pol2qm74 8542 44 HSP-72 HSP-72 NNP cord-015021-pol2qm74 8542 45 . . . cord-015021-pol2qm74 8543 1 Female female JJ cord-015021-pol2qm74 8543 2 ND4 ND4 NNP cord-015021-pol2qm74 8543 3 mice mouse NNS cord-015021-pol2qm74 8543 4 weighing weigh VBG cord-015021-pol2qm74 8543 5 22 22 CD cord-015021-pol2qm74 8543 6 - - SYM cord-015021-pol2qm74 8543 7 25 25 CD cord-015021-pol2qm74 8543 8 gms gm NNS cord-015021-pol2qm74 8543 9 were be VBD cord-015021-pol2qm74 8543 10 pretreated pretreate VBN cord-015021-pol2qm74 8543 11 with with IN cord-015021-pol2qm74 8543 12 arsenite arsenite JJ cord-015021-pol2qm74 8543 13 or or CC cord-015021-pol2qm74 8543 14 alcohol alcohol NN cord-015021-pol2qm74 8543 15 8 8 CD cord-015021-pol2qm74 8543 16 hours hour NNS cord-015021-pol2qm74 8543 17 prior prior RB cord-015021-pol2qm74 8543 18 to to TO cord-015021-pol2qm74 8543 19 challenge challenge NN cord-015021-pol2qm74 8543 20 with with IN cord-015021-pol2qm74 8543 21 Escherichia Escherichia NNP cord-015021-pol2qm74 8543 22 coli coli NNS cord-015021-pol2qm74 8543 23 endotoxin endotoxin NN cord-015021-pol2qm74 8543 24 ( ( -LRB- cord-015021-pol2qm74 8543 25 -LD -LD NNS cord-015021-pol2qm74 8543 26 80 80 CD cord-015021-pol2qm74 8543 27 ) ) -RRB- cord-015021-pol2qm74 8543 28 and and CC cord-015021-pol2qm74 8543 29 survival survival NN cord-015021-pol2qm74 8543 30 was be VBD cord-015021-pol2qm74 8543 31 compared compare VBN cord-015021-pol2qm74 8543 32 to to TO cord-015021-pol2qm74 8543 33 control control VB cord-015021-pol2qm74 8543 34 mice mouse NNS cord-015021-pol2qm74 8543 35 . . . cord-015021-pol2qm74 8544 1 Results result NNS cord-015021-pol2qm74 8544 2 : : : cord-015021-pol2qm74 8544 3 Survival survival NN cord-015021-pol2qm74 8544 4 at at IN cord-015021-pol2qm74 8544 5 24 24 CD cord-015021-pol2qm74 8544 6 hrs hrs NN cord-015021-pol2qm74 8544 7 . . . cord-015021-pol2qm74 8545 1 for for IN cord-015021-pol2qm74 8545 2 arsenite arsenite NNP cord-015021-pol2qm74 8545 3 treated treat VBN cord-015021-pol2qm74 8545 4 and and CC cord-015021-pol2qm74 8545 5 alcohol alcohol NN cord-015021-pol2qm74 8545 6 treated treat VBN cord-015021-pol2qm74 8546 1 mice mouse NNS cord-015021-pol2qm74 8546 2 was be VBD cord-015021-pol2qm74 8546 3 96 96 CD cord-015021-pol2qm74 8546 4 % % NN cord-015021-pol2qm74 8546 5 and and CC cord-015021-pol2qm74 8546 6 88 88 CD cord-015021-pol2qm74 8546 7 % % NN cord-015021-pol2qm74 8546 8 respectively respectively RB cord-015021-pol2qm74 8546 9 and and CC cord-015021-pol2qm74 8546 10 was be VBD cord-015021-pol2qm74 8546 11 statistically statistically RB cord-015021-pol2qm74 8546 12 different different JJ cord-015021-pol2qm74 8546 13 from from IN cord-015021-pol2qm74 8546 14 the the DT cord-015021-pol2qm74 8546 15 40 40 CD cord-015021-pol2qm74 8546 16 % % NN cord-015021-pol2qm74 8546 17 survival survival NN cord-015021-pol2qm74 8546 18 for for IN cord-015021-pol2qm74 8546 19 control control NN cord-015021-pol2qm74 8546 20 mice mouse NNS cord-015021-pol2qm74 8546 21 . . . cord-015021-pol2qm74 8547 1 ( ( -LRB- cord-015021-pol2qm74 8547 2 p<0.01 p<0.01 NN cord-015021-pol2qm74 8547 3 ) ) -RRB- cord-015021-pol2qm74 8548 1 ( ( -LRB- cord-015021-pol2qm74 8548 2 n=25 n=25 JJ cord-015021-pol2qm74 8548 3 mice mouse NNS cord-015021-pol2qm74 8548 4 per per IN cord-015021-pol2qm74 8548 5 group group NN cord-015021-pol2qm74 8548 6 ) ) -RRB- cord-015021-pol2qm74 8548 7 . . . cord-015021-pol2qm74 8549 1 However however RB cord-015021-pol2qm74 8549 2 , , , cord-015021-pol2qm74 8549 3 at at IN cord-015021-pol2qm74 8549 4 7 7 CD cord-015021-pol2qm74 8549 5 days day NNS cord-015021-pol2qm74 8549 6 post post NN cord-015021-pol2qm74 8549 7 endotoxin endotoxin NN cord-015021-pol2qm74 8549 8 , , , cord-015021-pol2qm74 8549 9 there there EX cord-015021-pol2qm74 8549 10 were be VBD cord-015021-pol2qm74 8549 11 no no DT cord-015021-pol2qm74 8549 12 differences difference NNS cord-015021-pol2qm74 8549 13 in in IN cord-015021-pol2qm74 8549 14 survival survival NN cord-015021-pol2qm74 8549 15 in in IN cord-015021-pol2qm74 8549 16 the the DT cord-015021-pol2qm74 8549 17 3 3 CD cord-015021-pol2qm74 8549 18 groups group NNS cord-015021-pol2qm74 8549 19 , , , cord-015021-pol2qm74 8549 20 i.e. i.e. FW cord-015021-pol2qm74 8549 21 , , , cord-015021-pol2qm74 8549 22 ~ ~ CD cord-015021-pol2qm74 8549 23 4 4 CD cord-015021-pol2qm74 8549 24 % % NN cord-015021-pol2qm74 8549 25 survival survival NN cord-015021-pol2qm74 8549 26 for for IN cord-015021-pol2qm74 8549 27 all all DT cord-015021-pol2qm74 8549 28 3 3 CD cord-015021-pol2qm74 8549 29 groups group NNS cord-015021-pol2qm74 8549 30 . . . cord-015021-pol2qm74 8550 1 In in IN cord-015021-pol2qm74 8550 2 contrast contrast NN cord-015021-pol2qm74 8550 3 , , , cord-015021-pol2qm74 8550 4 the the DT cord-015021-pol2qm74 8550 5 protective protective JJ cord-015021-pol2qm74 8550 6 effect effect NN cord-015021-pol2qm74 8550 7 of of IN cord-015021-pol2qm74 8550 8 hyperthermia hyperthermia NN cord-015021-pol2qm74 8550 9 remains remain VBZ cord-015021-pol2qm74 8550 10 present present JJ cord-015021-pol2qm74 8550 11 at at IN cord-015021-pol2qm74 8550 12 7 7 CD cord-015021-pol2qm74 8550 13 days day NNS cord-015021-pol2qm74 8550 14 , , , cord-015021-pol2qm74 8550 15 i.e. i.e. FW cord-015021-pol2qm74 8550 16 , , , cord-015021-pol2qm74 8550 17 ~ ~ NFP cord-015021-pol2qm74 8550 18 70 70 CD cord-015021-pol2qm74 8550 19 % % NN cord-015021-pol2qm74 8550 20 survival survival NN cord-015021-pol2qm74 8550 21 vs vs IN cord-015021-pol2qm74 8550 22 20 20 CD cord-015021-pol2qm74 8550 23 % % NN cord-015021-pol2qm74 8550 24 survival survival NN cord-015021-pol2qm74 8550 25 control control NN cord-015021-pol2qm74 8550 26 . . . cord-015021-pol2qm74 8551 1 Conclusion conclusion NN cord-015021-pol2qm74 8551 2 : : : cord-015021-pol2qm74 8552 1 The the DT cord-015021-pol2qm74 8552 2 protective protective JJ cord-015021-pol2qm74 8552 3 effect effect NN cord-015021-pol2qm74 8552 4 of of IN cord-015021-pol2qm74 8552 5 heat heat NN cord-015021-pol2qm74 8552 6 is be VBZ cord-015021-pol2qm74 8552 7 probably probably RB cord-015021-pol2qm74 8552 8 due due JJ cord-015021-pol2qm74 8552 9 to to IN cord-015021-pol2qm74 8552 10 other other JJ cord-015021-pol2qm74 8552 11 factors factor NNS cord-015021-pol2qm74 8552 12 such such JJ cord-015021-pol2qm74 8552 13 as as IN cord-015021-pol2qm74 8552 14 the the DT cord-015021-pol2qm74 8552 15 effect effect NN cord-015021-pol2qm74 8552 16 of of IN cord-015021-pol2qm74 8552 17 hyperthermia hyperthermia NN cord-015021-pol2qm74 8552 18 to to TO cord-015021-pol2qm74 8552 19 release release VB cord-015021-pol2qm74 8552 20 IL IL NNP cord-015021-pol2qm74 8552 21 - - HYPH cord-015021-pol2qm74 8552 22 lc~ lc~ NN cord-015021-pol2qm74 8552 23 and and CC cord-015021-pol2qm74 8552 24 is be VBZ cord-015021-pol2qm74 8552 25 not not RB cord-015021-pol2qm74 8552 26 due due JJ cord-015021-pol2qm74 8552 27 solely solely RB cord-015021-pol2qm74 8552 28 to to IN cord-015021-pol2qm74 8552 29 HSP-72 HSP-72 NNP cord-015021-pol2qm74 8552 30 formation formation NN cord-015021-pol2qm74 8552 31 . . . cord-015021-pol2qm74 8553 1 It -PRON- PRP cord-015021-pol2qm74 8553 2 was be VBD cord-015021-pol2qm74 8553 3 the the DT cord-015021-pol2qm74 8553 4 aim aim NN cord-015021-pol2qm74 8553 5 of of IN cord-015021-pol2qm74 8553 6 the the DT cord-015021-pol2qm74 8553 7 study study NN cord-015021-pol2qm74 8553 8 to to TO cord-015021-pol2qm74 8553 9 examine examine VB cord-015021-pol2qm74 8553 10 whether whether IN cord-015021-pol2qm74 8553 11 bacteria bacteria NNS cord-015021-pol2qm74 8553 12 play play VBP cord-015021-pol2qm74 8553 13 a a DT cord-015021-pol2qm74 8553 14 causative causative JJ cord-015021-pol2qm74 8553 15 role role NN cord-015021-pol2qm74 8553 16 in in IN cord-015021-pol2qm74 8553 17 the the DT cord-015021-pol2qm74 8553 18 pathogenesis pathogenesis NN cord-015021-pol2qm74 8553 19 of of IN cord-015021-pol2qm74 8553 20 anastomotic anastomotic JJ cord-015021-pol2qm74 8553 21 insufficiency insufficiency NN cord-015021-pol2qm74 8553 22 following follow VBG cord-015021-pol2qm74 8553 23 gastrectomy gastrectomy NN cord-015021-pol2qm74 8553 24 in in IN cord-015021-pol2qm74 8553 25 man man NN cord-015021-pol2qm74 8553 26 . . . cord-015021-pol2qm74 8554 1 The the DT cord-015021-pol2qm74 8554 2 study study NN cord-015021-pol2qm74 8554 3 was be VBD cord-015021-pol2qm74 8554 4 carried carry VBN cord-015021-pol2qm74 8554 5 out out RP cord-015021-pol2qm74 8554 6 in in IN cord-015021-pol2qm74 8554 7 form form NN cord-015021-pol2qm74 8554 8 of of IN cord-015021-pol2qm74 8554 9 a a DT cord-015021-pol2qm74 8554 10 prospective prospective NN cord-015021-pol2qm74 8554 11 , , , cord-015021-pol2qm74 8554 12 randemised randemised JJ cord-015021-pol2qm74 8554 13 , , , cord-015021-pol2qm74 8554 14 double double JJ cord-015021-pol2qm74 8554 15 - - HYPH cord-015021-pol2qm74 8554 16 blind blind JJ cord-015021-pol2qm74 8554 17 , , , cord-015021-pol2qm74 8554 18 multicenter multicenter JJ cord-015021-pol2qm74 8554 19 trial trial NN cord-015021-pol2qm74 8554 20 . . . cord-015021-pol2qm74 8555 1 Primary primary JJ cord-015021-pol2qm74 8555 2 endpoints endpoint NNS cord-015021-pol2qm74 8555 3 were be VBD cord-015021-pol2qm74 8555 4 the the DT cord-015021-pol2qm74 8555 5 rate rate NN cord-015021-pol2qm74 8555 6 of of IN cord-015021-pol2qm74 8555 7 anastomotic anastomotic JJ cord-015021-pol2qm74 8555 8 insufficiencies insufficiency NNS cord-015021-pol2qm74 8555 9 , , , cord-015021-pol2qm74 8555 10 infectious infectious JJ cord-015021-pol2qm74 8555 11 - - HYPH cord-015021-pol2qm74 8555 12 and and CC cord-015021-pol2qm74 8555 13 uncomplicated uncomplicated JJ cord-015021-pol2qm74 8555 14 postoperative postoperative JJ cord-015021-pol2qm74 8555 15 courses course NNS cord-015021-pol2qm74 8555 16 . . . cord-015021-pol2qm74 8556 1 All all DT cord-015021-pol2qm74 8556 2 pat pat VBP cord-015021-pol2qm74 8556 3 . . NNP cord-015021-pol2qm74 8556 4 received receive VBD cord-015021-pol2qm74 8556 5 a a DT cord-015021-pol2qm74 8556 6 periop periop NNS cord-015021-pol2qm74 8556 7 , , , cord-015021-pol2qm74 8556 8 i.v i.v NNP cord-015021-pol2qm74 8556 9 . . NNP cord-015021-pol2qm74 8556 10 prophylaxis prophylaxis NN cord-015021-pol2qm74 8556 11 with with IN cord-015021-pol2qm74 8556 12 Cefotaxim Cefotaxim NNP cord-015021-pol2qm74 8556 13 . . . cord-015021-pol2qm74 8557 1 Identical identical JJ cord-015021-pol2qm74 8557 2 numbered number VBN cord-015021-pol2qm74 8557 3 vial vial NN cord-015021-pol2qm74 8557 4 either either CC cord-015021-pol2qm74 8557 5 contained contain VBD cord-015021-pol2qm74 8557 6 Placebo Placebo NNP cord-015021-pol2qm74 8557 7 or or CC cord-015021-pol2qm74 8557 8 Polymyxin Polymyxin NNP cord-015021-pol2qm74 8557 9 B B NNP cord-015021-pol2qm74 8557 10 , , , cord-015021-pol2qm74 8557 11 Tobramycin Tobramycin NNPS cord-015021-pol2qm74 8557 12 , , , cord-015021-pol2qm74 8557 13 Vancomycin Vancomycin NNP cord-015021-pol2qm74 8557 14 and and CC cord-015021-pol2qm74 8557 15 Amphotericin Amphotericin NNP cord-015021-pol2qm74 8557 16 B B NNP cord-015021-pol2qm74 8557 17 . . . cord-015021-pol2qm74 8558 1 The the DT cord-015021-pol2qm74 8558 2 vials vial NNS cord-015021-pol2qm74 8558 3 were be VBD cord-015021-pol2qm74 8558 4 administered administer VBN cord-015021-pol2qm74 8558 5 4X 4x CD cord-015021-pol2qm74 8558 6 per per IN cord-015021-pol2qm74 8558 7 day day NN cord-015021-pol2qm74 8558 8 from from IN cord-015021-pol2qm74 8558 9 the the DT cord-015021-pol2qm74 8558 10 day day NN cord-015021-pol2qm74 8558 11 be be VB cord-015021-pol2qm74 8558 12 ~ ~ NFP cord-015021-pol2qm74 8558 13 fore fore IN cord-015021-pol2qm74 8558 14 the the DT cord-015021-pol2qm74 8558 15 operation operation NN cord-015021-pol2qm74 8558 16 until until IN cord-015021-pol2qm74 8558 17 the the DT cord-015021-pol2qm74 8558 18 7th 7th JJ cord-015021-pol2qm74 8558 19 postop postop NN cord-015021-pol2qm74 8558 20 , , , cord-015021-pol2qm74 8558 21 day day NN cord-015021-pol2qm74 8558 22 . . . cord-015021-pol2qm74 8559 1 Insufficiencies insufficiency NNS cord-015021-pol2qm74 8559 2 were be VBD cord-015021-pol2qm74 8559 3 detected detect VBN cord-015021-pol2qm74 8559 4 by by IN cord-015021-pol2qm74 8559 5 gastrographin gastrographin NNP cord-015021-pol2qm74 8559 6 swallow swallow NNP cord-015021-pol2qm74 8559 7 and and CC cord-015021-pol2qm74 8559 8 recorded record VBN cord-015021-pol2qm74 8559 9 by by IN cord-015021-pol2qm74 8559 10 X x NN cord-015021-pol2qm74 8559 11 - - NN cord-015021-pol2qm74 8559 12 ray ray NN cord-015021-pol2qm74 8559 13 on on IN cord-015021-pol2qm74 8559 14 day day NN cord-015021-pol2qm74 8559 15 7 7 CD cord-015021-pol2qm74 8559 16 postop postop NN cord-015021-pol2qm74 8559 17 .. .. . cord-015021-pol2qm74 8560 1 Evaluation evaluation NN cord-015021-pol2qm74 8560 2 was be VBD cord-015021-pol2qm74 8560 3 carried carry VBN cord-015021-pol2qm74 8560 4 out out RP cord-015021-pol2qm74 8560 5 on on IN cord-015021-pol2qm74 8560 6 an an DT cord-015021-pol2qm74 8560 7 " " `` cord-015021-pol2qm74 8560 8 intention intention NN cord-015021-pol2qm74 8560 9 to to IN cord-015021-pol2qm74 8560 10 treat'basis treat'basis ADD cord-015021-pol2qm74 8560 11 . . . cord-015021-pol2qm74 8561 1 Statistical statistical JJ cord-015021-pol2qm74 8561 2 analysis analysis NN cord-015021-pol2qm74 8561 3 was be VBD cord-015021-pol2qm74 8561 4 done do VBN cord-015021-pol2qm74 8561 5 with with IN cord-015021-pol2qm74 8561 6 the the DT cord-015021-pol2qm74 8561 7 Pearson Pearson NNP cord-015021-pol2qm74 8561 8 's 's POS cord-015021-pol2qm74 8561 9 Chi Chi NNP cord-015021-pol2qm74 8561 10 Square Square NNP cord-015021-pol2qm74 8561 11 and and CC cord-015021-pol2qm74 8561 12 Fisher Fisher NNP cord-015021-pol2qm74 8561 13 's 's POS cord-015021-pol2qm74 8561 14 Exact exact JJ cord-015021-pol2qm74 8561 15 Tests~ Tests~ . cord-015021-pol2qm74 8561 16 Results result NNS cord-015021-pol2qm74 8561 17 : : : cord-015021-pol2qm74 8561 18 Interim interim JJ cord-015021-pol2qm74 8561 19 analysis analysis NN cord-015021-pol2qm74 8561 20 was be VBD cord-015021-pol2qm74 8561 21 carried carry VBN cord-015021-pol2qm74 8561 22 out out RP cord-015021-pol2qm74 8561 23 in in IN cord-015021-pol2qm74 8561 24 3/93 3/93 CD cord-015021-pol2qm74 8561 25 after after IN cord-015021-pol2qm74 8561 26 137 137 CD cord-015021-pol2qm74 8561 27 pat pat NNS cord-015021-pol2qm74 8561 28 . . NNP cord-015021-pol2qm74 8561 29 had have VBD cord-015021-pol2qm74 8561 30 been be VBN cord-015021-pol2qm74 8561 31 recruited recruit VBN cord-015021-pol2qm74 8561 32 . . . cord-015021-pol2qm74 8562 1 Along along IN cord-015021-pol2qm74 8562 2 with with IN cord-015021-pol2qm74 8562 3 a a DT cord-015021-pol2qm74 8562 4 significant significant JJ cord-015021-pol2qm74 8562 5 reduction reduction NN cord-015021-pol2qm74 8562 6 of of IN cord-015021-pol2qm74 8562 7 S.aureus s.aureu NNS cord-015021-pol2qm74 8562 8 and and CC cord-015021-pol2qm74 8562 9 enterobacteria enterobacteria NN cord-015021-pol2qm74 8562 10 there there EX cord-015021-pol2qm74 8562 11 was be VBD cord-015021-pol2qm74 8562 12 a a DT cord-015021-pol2qm74 8562 13 reduction reduction NN cord-015021-pol2qm74 8562 14 in in IN cord-015021-pol2qm74 8562 15 the the DT cord-015021-pol2qm74 8562 16 rate rate NN cord-015021-pol2qm74 8562 17 of of IN cord-015021-pol2qm74 8562 18 anastomotic anastomotic JJ cord-015021-pol2qm74 8562 19 insufficiency insufficiency NN cord-015021-pol2qm74 8562 20 of of IN cord-015021-pol2qm74 8562 21 the the DT cord-015021-pol2qm74 8562 22 esophago esophago JJ cord-015021-pol2qm74 8562 23 - - HYPH cord-015021-pol2qm74 8562 24 jejunostomy jejunostomy NN cord-015021-pol2qm74 8562 25 from from IN cord-015021-pol2qm74 8562 26 10.6 10.6 CD cord-015021-pol2qm74 8562 27 % % NN cord-015021-pol2qm74 8562 28 in in IN cord-015021-pol2qm74 8562 29 the the DT cord-015021-pol2qm74 8562 30 Placebo Placebo NNP cord-015021-pol2qm74 8562 31 - - HYPH cord-015021-pol2qm74 8562 32 group group NN cord-015021-pol2qm74 8562 33 to to IN cord-015021-pol2qm74 8562 34 3.5 3.5 CD cord-015021-pol2qm74 8562 35 % % NN cord-015021-pol2qm74 8562 36 in in IN cord-015021-pol2qm74 8562 37 the the DT cord-015021-pol2qm74 8562 38 treatment treatment NN cord-015021-pol2qm74 8562 39 group group NN cord-015021-pol2qm74 8562 40 . . . cord-015021-pol2qm74 8563 1 The the DT cord-015021-pol2qm74 8563 2 difference difference NN cord-015021-pol2qm74 8563 3 was be VBD cord-015021-pol2qm74 8563 4 not not RB cord-015021-pol2qm74 8563 5 yet yet RB cord-015021-pol2qm74 8563 6 significant significant JJ cord-015021-pol2qm74 8563 7 . . . cord-015021-pol2qm74 8564 1 The the DT cord-015021-pol2qm74 8564 2 rate rate NN cord-015021-pol2qm74 8564 3 of of IN cord-015021-pol2qm74 8564 4 nosocomial nosocomial JJ cord-015021-pol2qm74 8564 5 infections infection NNS cord-015021-pol2qm74 8564 6 ( ( -LRB- cord-015021-pol2qm74 8564 7 e.g. e.g. RB cord-015021-pol2qm74 8564 8 respiratory respiratory JJ cord-015021-pol2qm74 8564 9 tract tract NN cord-015021-pol2qm74 8564 10 infection infection NN cord-015021-pol2qm74 8564 11 and and CC cord-015021-pol2qm74 8564 12 UTI UTI NNP cord-015021-pol2qm74 8564 13 ) ) -RRB- cord-015021-pol2qm74 8564 14 were be VBD cord-015021-pol2qm74 8564 15 significantly significantly RB cord-015021-pol2qm74 8564 16 reduced reduce VBN cord-015021-pol2qm74 8564 17 from from IN cord-015021-pol2qm74 8564 18 33.3 33.3 CD cord-015021-pol2qm74 8564 19 % % NN cord-015021-pol2qm74 8564 20 in in IN cord-015021-pol2qm74 8564 21 the the DT cord-015021-pol2qm74 8564 22 Placebo Placebo NNP cord-015021-pol2qm74 8564 23 - - HYPH cord-015021-pol2qm74 8564 24 group group NN cord-015021-pol2qm74 8564 25 to to IN cord-015021-pol2qm74 8564 26 16.4 16.4 CD cord-015021-pol2qm74 8564 27 % % NN cord-015021-pol2qm74 8564 28 in in IN cord-015021-pol2qm74 8564 29 the the DT cord-015021-pol2qm74 8564 30 Treatment treatment NN cord-015021-pol2qm74 8564 31 - - HYPH cord-015021-pol2qm74 8564 32 group group NN cord-015021-pol2qm74 8564 33 ( ( -LRB- cord-015021-pol2qm74 8564 34 p p NN cord-015021-pol2qm74 8564 35 ~ ~ NFP cord-015021-pol2qm74 8564 36 0.0281;Fisher 0.0281;fisher CD cord-015021-pol2qm74 8564 37 's 's POS cord-015021-pol2qm74 8564 38 Exact Exact NNP cord-015021-pol2qm74 8564 39 Test Test NNP cord-015021-pol2qm74 8564 40 ) ) -RRB- cord-015021-pol2qm74 8564 41 . . . cord-015021-pol2qm74 8565 1 In in IN cord-015021-pol2qm74 8565 2 march march NNP cord-015021-pol2qm74 8565 3 1994 1994 CD cord-015021-pol2qm74 8565 4 final final JJ cord-015021-pol2qm74 8565 5 results result NNS cord-015021-pol2qm74 8565 6 with with IN cord-015021-pol2qm74 8565 7 more more JJR cord-015021-pol2qm74 8565 8 than than IN cord-015021-pol2qm74 8565 9 200 200 CD cord-015021-pol2qm74 8565 10 patients patient NNS cord-015021-pol2qm74 8565 11 will will MD cord-015021-pol2qm74 8565 12 be be VB cord-015021-pol2qm74 8565 13 presented present VBN cord-015021-pol2qm74 8565 14 for for IN cord-015021-pol2qm74 8565 15 the the DT cord-015021-pol2qm74 8565 16 first first JJ cord-015021-pol2qm74 8565 17 time time NN cord-015021-pol2qm74 8565 18 . . . cord-015021-pol2qm74 8566 1 (= (= NNP cord-015021-pol2qm74 8566 2 pO2 pO2 NNP cord-015021-pol2qm74 8566 3 < < XX cord-015021-pol2qm74 8567 1 80 80 CD cord-015021-pol2qm74 8567 2 mm mm NN cord-015021-pol2qm74 8568 1 Hg Hg NNP cord-015021-pol2qm74 8568 2 , , , cord-015021-pol2qm74 8568 3 b b NNP cord-015021-pol2qm74 8568 4 s s POS cord-015021-pol2qm74 8568 5 - - HYPH cord-015021-pol2qm74 8568 6 creatinin creatinin NNP cord-015021-pol2qm74 8568 7 > > XX cord-015021-pol2qm74 8568 8 2 2 CD cord-015021-pol2qm74 8568 9 mg% mg% CD cord-015021-pol2qm74 8568 10 ) ) -RRB- cord-015021-pol2qm74 8568 11 . . . cord-015021-pol2qm74 8569 1 Respiratory respiratory JJ cord-015021-pol2qm74 8569 2 insufficiency insufficiency NN cord-015021-pol2qm74 8569 3 was be VBD cord-015021-pol2qm74 8569 4 the the DT cord-015021-pol2qm74 8569 5 most most RBS cord-015021-pol2qm74 8569 6 frequent frequent JJ cord-015021-pol2qm74 8569 7 systemic systemic JJ cord-015021-pol2qm74 8569 8 complication complication NN cord-015021-pol2qm74 8569 9 followed follow VBN cord-015021-pol2qm74 8569 10 by by IN cord-015021-pol2qm74 8569 11 sepsis sepsis NN cord-015021-pol2qm74 8569 12 and and CC cord-015021-pol2qm74 8569 13 respiratory respiratory JJ cord-015021-pol2qm74 8569 14 insufficiency insufficiency NN cord-015021-pol2qm74 8569 15 . . . cord-015021-pol2qm74 8570 1 Etiology etiology NN cord-015021-pol2qm74 8570 2 of of IN cord-015021-pol2qm74 8570 3 pancreatitis pancreatitis NN cord-015021-pol2qm74 8570 4 and and CC cord-015021-pol2qm74 8570 5 initial initial JJ cord-015021-pol2qm74 8570 6 serum serum NN cord-015021-pol2qm74 8570 7 increase increase NN cord-015021-pol2qm74 8570 8 of of IN cord-015021-pol2qm74 8570 9 pancreatic pancreatic JJ cord-015021-pol2qm74 8570 10 enzymes enzyme NNS cord-015021-pol2qm74 8570 11 predicted predict VBD cord-015021-pol2qm74 8570 12 neither neither CC cord-015021-pol2qm74 8570 13 complications complication NNS cord-015021-pol2qm74 8570 14 nor nor CC cord-015021-pol2qm74 8570 15 outcome outcome NN cord-015021-pol2qm74 8570 16 . . . cord-015021-pol2qm74 8571 1 Only only RB cord-015021-pol2qm74 8571 2 2 2 CD cord-015021-pol2qm74 8571 3 of of IN cord-015021-pol2qm74 8571 4 14 14 CD cord-015021-pol2qm74 8571 5 deaths death NNS cord-015021-pol2qm74 8571 6 occurred occur VBD cord-015021-pol2qm74 8571 7 during during IN cord-015021-pol2qm74 8571 8 the the DT cord-015021-pol2qm74 8571 9 1st 1st JJ cord-015021-pol2qm74 8571 10 week week NN cord-015021-pol2qm74 8571 11 , , , cord-015021-pol2qm74 8571 12 all all DT cord-015021-pol2qm74 8571 13 other other JJ cord-015021-pol2qm74 8571 14 deaths death NNS cord-015021-pol2qm74 8571 15 occurred occur VBD cord-015021-pol2qm74 8571 16 late late RB cord-015021-pol2qm74 8571 17 ( ( -LRB- cord-015021-pol2qm74 8571 18 after after IN cord-015021-pol2qm74 8571 19 4 4 CD cord-015021-pol2qm74 8571 20 - - SYM cord-015021-pol2qm74 8571 21 12 12 CD cord-015021-pol2qm74 8571 22 weeks week NNS cord-015021-pol2qm74 8571 23 ) ) -RRB- cord-015021-pol2qm74 8571 24 , , , cord-015021-pol2qm74 8571 25 generally generally RB cord-015021-pol2qm74 8571 26 as as IN cord-015021-pol2qm74 8571 27 the the DT cord-015021-pol2qm74 8571 28 consequence consequence NN cord-015021-pol2qm74 8571 29 of of IN cord-015021-pol2qm74 8571 30 septic septic JJ cord-015021-pol2qm74 8571 31 complications complication NNS cord-015021-pol2qm74 8571 32 and and CC cord-015021-pol2qm74 8571 33 multi multi JJ cord-015021-pol2qm74 8571 34 - - JJ cord-015021-pol2qm74 8571 35 organ organ JJ cord-015021-pol2qm74 8571 36 failure failure NN cord-015021-pol2qm74 8571 37 . . . cord-015021-pol2qm74 8572 1 High high JJ cord-015021-pol2qm74 8572 2 levels level NNS cord-015021-pol2qm74 8572 3 of of IN cord-015021-pol2qm74 8572 4 CRP CRP NNP cord-015021-pol2qm74 8572 5 were be VBD cord-015021-pol2qm74 8572 6 correlated correlate VBN cord-015021-pol2qm74 8572 7 with with IN cord-015021-pol2qm74 8572 8 a a DT cord-015021-pol2qm74 8572 9 compliacted compliacted JJ cord-015021-pol2qm74 8572 10 course course NN cord-015021-pol2qm74 8572 11 and and CC cord-015021-pol2qm74 8572 12 a a DT cord-015021-pol2qm74 8572 13 fatal fatal JJ cord-015021-pol2qm74 8572 14 outcome outcome NN cord-015021-pol2qm74 8572 15 . . . cord-015021-pol2qm74 8573 1 Although although IN cord-015021-pol2qm74 8573 2 same same JJ cord-015021-pol2qm74 8573 3 cytokines cytokine NNS cord-015021-pol2qm74 8573 4 ( ( -LRB- cord-015021-pol2qm74 8573 5 e.g. e.g. RB cord-015021-pol2qm74 8573 6 11 11 CD cord-015021-pol2qm74 8573 7 - - HYPH cord-015021-pol2qm74 8573 8 -6 -6 NN cord-015021-pol2qm74 8573 9 ) ) -RRB- cord-015021-pol2qm74 8573 10 were be VBD cord-015021-pol2qm74 8573 11 found find VBN cord-015021-pol2qm74 8573 12 increased increase VBN cord-015021-pol2qm74 8573 13 in in IN cord-015021-pol2qm74 8573 14 severe severe JJ cord-015021-pol2qm74 8573 15 disease disease NN cord-015021-pol2qm74 8573 16 , , , cord-015021-pol2qm74 8573 17 the the DT cord-015021-pol2qm74 8573 18 predictive predictive JJ cord-015021-pol2qm74 8573 19 value value NN cord-015021-pol2qm74 8573 20 of of IN cord-015021-pol2qm74 8573 21 these these DT cord-015021-pol2qm74 8573 22 markers marker NNS cord-015021-pol2qm74 8573 23 was be VBD cord-015021-pol2qm74 8573 24 not not RB cord-015021-pol2qm74 8573 25 better well JJR cord-015021-pol2qm74 8573 26 than than IN cord-015021-pol2qm74 8573 27 the the DT cord-015021-pol2qm74 8573 28 combination combination NN cord-015021-pol2qm74 8573 29 of of IN cord-015021-pol2qm74 8573 30 ctinical ctinical JJ cord-015021-pol2qm74 8573 31 scores score NNS cord-015021-pol2qm74 8573 32 ( ( -LRB- cord-015021-pol2qm74 8573 33 Ranson Ranson NNP cord-015021-pol2qm74 8573 34 , , , cord-015021-pol2qm74 8573 35 Imrie Imrie NNP cord-015021-pol2qm74 8573 36 , , , cord-015021-pol2qm74 8573 37 APACHE APACHE NNP cord-015021-pol2qm74 8573 38 II II NNP cord-015021-pol2qm74 8573 39 ) ) -RRB- cord-015021-pol2qm74 8573 40 with with IN cord-015021-pol2qm74 8573 41 GT GT NNP cord-015021-pol2qm74 8573 42 or or CC cord-015021-pol2qm74 8573 43 CRP CRP NNP cord-015021-pol2qm74 8573 44 . . . cord-015021-pol2qm74 8574 1 CONCLUSIONS conclusion NNS cord-015021-pol2qm74 8574 2 : : : cord-015021-pol2qm74 8575 1 Intensive intensive JJ cord-015021-pol2qm74 8575 2 care care NN cord-015021-pol2qm74 8575 3 medicine medicine NN cord-015021-pol2qm74 8575 4 can can MD cord-015021-pol2qm74 8575 5 often often RB cord-015021-pol2qm74 8575 6 control control VB cord-015021-pol2qm74 8575 7 the the DT cord-015021-pol2qm74 8575 8 inital inital JJ cord-015021-pol2qm74 8575 9 shock shock NN cord-015021-pol2qm74 8575 10 situation situation NN cord-015021-pol2qm74 8575 11 in in IN cord-015021-pol2qm74 8575 12 severe severe JJ cord-015021-pol2qm74 8575 13 pancreatitis pancreatitis NN cord-015021-pol2qm74 8575 14 . . . cord-015021-pol2qm74 8576 1 Thus thus RB cord-015021-pol2qm74 8576 2 . . . cord-015021-pol2qm74 8577 1 only only RB cord-015021-pol2qm74 8577 2 15 15 CD cord-015021-pol2qm74 8577 3 % % NN cord-015021-pol2qm74 8577 4 of of IN cord-015021-pol2qm74 8577 5 deaths death NNS cord-015021-pol2qm74 8577 6 today today NN cord-015021-pol2qm74 8577 7 occur occur VBP cord-015021-pol2qm74 8577 8 eady eady RB cord-015021-pol2qm74 8577 9 in in IN cord-015021-pol2qm74 8577 10 the the DT cord-015021-pol2qm74 8577 11 course course NN cord-015021-pol2qm74 8577 12 of of IN cord-015021-pol2qm74 8577 13 the the DT cord-015021-pol2qm74 8577 14 disease disease NN cord-015021-pol2qm74 8577 15 , , , cord-015021-pol2qm74 8577 16 whereas whereas IN cord-015021-pol2qm74 8577 17 this this DT cord-015021-pol2qm74 8577 18 percentage percentage NN cord-015021-pol2qm74 8577 19 varied varied JJ cord-015021-pol2qm74 8577 20 between between IN cord-015021-pol2qm74 8577 21 40 40 CD cord-015021-pol2qm74 8577 22 - - SYM cord-015021-pol2qm74 8577 23 70 70 CD cord-015021-pol2qm74 8577 24 % % NN cord-015021-pol2qm74 8577 25 just just RB cord-015021-pol2qm74 8577 26 10 10 CD cord-015021-pol2qm74 8577 27 years year NNS cord-015021-pol2qm74 8577 28 ago ago RB cord-015021-pol2qm74 8577 29 . . . cord-015021-pol2qm74 8578 1 Nowadays nowadays RB cord-015021-pol2qm74 8578 2 , , , cord-015021-pol2qm74 8578 3 most most JJS cord-015021-pol2qm74 8578 4 deaths death NNS cord-015021-pol2qm74 8578 5 are be VBP cord-015021-pol2qm74 8578 6 caused cause VBN cord-015021-pol2qm74 8578 7 by by IN cord-015021-pol2qm74 8578 8 late late JJ cord-015021-pol2qm74 8578 9 septic septic JJ cord-015021-pol2qm74 8578 10 complications complication NNS cord-015021-pol2qm74 8578 11 and and CC cord-015021-pol2qm74 8578 12 multi multi JJ cord-015021-pol2qm74 8578 13 - - JJ cord-015021-pol2qm74 8578 14 organ organ JJ cord-015021-pol2qm74 8578 15 failure failure NN cord-015021-pol2qm74 8578 16 . . . cord-015021-pol2qm74 8579 1 Ranson Ranson NNP cord-015021-pol2qm74 8579 2 - - HYPH cord-015021-pol2qm74 8579 3 and and CC cord-015021-pol2qm74 8579 4 CT CT NNP cord-015021-pol2qm74 8579 5 - - HYPH cord-015021-pol2qm74 8579 6 scores score NNS cord-015021-pol2qm74 8579 7 as as RB cord-015021-pol2qm74 8579 8 well well RB cord-015021-pol2qm74 8579 9 as as IN cord-015021-pol2qm74 8579 10 serum serum NN cord-015021-pol2qm74 8579 11 CRP CRP NNP cord-015021-pol2qm74 8579 12 predict predict VBP cord-015021-pol2qm74 8579 13 a a DT cord-015021-pol2qm74 8579 14 course course NN cord-015021-pol2qm74 8579 15 with with IN cord-015021-pol2qm74 8579 16 systemic systemic JJ cord-015021-pol2qm74 8579 17 complications complication NNS cord-015021-pol2qm74 8579 18 ; ; : cord-015021-pol2qm74 8579 19 they -PRON- PRP cord-015021-pol2qm74 8579 20 are be VBP cord-015021-pol2qm74 8579 21 less less RBR cord-015021-pol2qm74 8579 22 helpful helpful JJ cord-015021-pol2qm74 8579 23 for for IN cord-015021-pol2qm74 8579 24 prediction prediction NN cord-015021-pol2qm74 8579 25 of of IN cord-015021-pol2qm74 8579 26 sepsis sepsis NN cord-015021-pol2qm74 8579 27 and and CC cord-015021-pol2qm74 8579 28 late late JJ cord-015021-pol2qm74 8579 29 mortality mortality NN cord-015021-pol2qm74 8579 30 . . . cord-015021-pol2qm74 8580 1 It -PRON- PRP cord-015021-pol2qm74 8580 2 is be VBZ cord-015021-pol2qm74 8580 3 doubtful doubtful JJ cord-015021-pol2qm74 8580 4 whether whether IN cord-015021-pol2qm74 8580 5 measurements measurement NNS cord-015021-pol2qm74 8580 6 of of IN cord-015021-pol2qm74 8580 7 cytokines cytokine NNS cord-015021-pol2qm74 8580 8 will will MD cord-015021-pol2qm74 8580 9 help help VB cord-015021-pol2qm74 8580 10 to to TO cord-015021-pol2qm74 8580 11 better better RB cord-015021-pol2qm74 8580 12 predict predict VB cord-015021-pol2qm74 8580 13 the the DT cord-015021-pol2qm74 8580 14 late late JJ cord-015021-pol2qm74 8580 15 outcome outcome NN cord-015021-pol2qm74 8580 16 . . . cord-015021-pol2qm74 8581 1 As as IN cord-015021-pol2qm74 8581 2 yet yet RB cord-015021-pol2qm74 8581 3 , , , cord-015021-pol2qm74 8581 4 only only RB cord-015021-pol2qm74 8581 5 careful careful JJ cord-015021-pol2qm74 8581 6 and and CC cord-015021-pol2qm74 8581 7 continuous continuous JJ cord-015021-pol2qm74 8581 8 monitoring monitoring NN cord-015021-pol2qm74 8581 9 of of IN cord-015021-pol2qm74 8581 10 patients patient NNS cord-015021-pol2qm74 8581 11 ( ( -LRB- cord-015021-pol2qm74 8581 12 e.g. e.g. RB cord-015021-pol2qm74 8581 13 by by IN cord-015021-pol2qm74 8581 14 APACHE APACHE NNP cord-015021-pol2qm74 8581 15 scores score NNS cord-015021-pol2qm74 8581 16 ) ) -RRB- cord-015021-pol2qm74 8581 17 may may MD cord-015021-pol2qm74 8581 18 help help VB cord-015021-pol2qm74 8581 19 to to TO cord-015021-pol2qm74 8581 20 early early RB cord-015021-pol2qm74 8581 21 identify identify VB cord-015021-pol2qm74 8581 22 those those DT cord-015021-pol2qm74 8581 23 who who WP cord-015021-pol2qm74 8581 24 develop develop VBP cord-015021-pol2qm74 8581 25 septic septic JJ cord-015021-pol2qm74 8581 26 complications complication NNS cord-015021-pol2qm74 8581 27 and and CC cord-015021-pol2qm74 8581 28 multi multi JJ cord-015021-pol2qm74 8581 29 - - JJ cord-015021-pol2qm74 8581 30 organ organ JJ cord-015021-pol2qm74 8581 31 failure failure NN cord-015021-pol2qm74 8581 32 . . . cord-015021-pol2qm74 8582 1 The the DT cord-015021-pol2qm74 8582 2 classic classic JJ cord-015021-pol2qm74 8582 3 description description NN cord-015021-pol2qm74 8582 4 of of IN cord-015021-pol2qm74 8582 5 severe severe JJ cord-015021-pol2qm74 8582 6 acute acute JJ cord-015021-pol2qm74 8582 7 pancreatitis pancreatitis NN cord-015021-pol2qm74 8582 8 has have VBZ cord-015021-pol2qm74 8582 9 hinged hinge VBN cord-015021-pol2qm74 8582 10 upon upon IN cord-015021-pol2qm74 8582 11 the the DT cord-015021-pol2qm74 8582 12 release release NN cord-015021-pol2qm74 8582 13 of of IN cord-015021-pol2qm74 8582 14 large large JJ cord-015021-pol2qm74 8582 15 volumes volume NNS cord-015021-pol2qm74 8582 16 of of IN cord-015021-pol2qm74 8582 17 activated activate VBN cord-015021-pol2qm74 8582 18 enzymes enzyme NNS cord-015021-pol2qm74 8582 19 into into IN cord-015021-pol2qm74 8582 20 the the DT cord-015021-pol2qm74 8582 21 peritoneal peritoneal JJ cord-015021-pol2qm74 8582 22 cavity cavity NN cord-015021-pol2qm74 8582 23 and and CC cord-015021-pol2qm74 8582 24 thertce thertce NNP cord-015021-pol2qm74 8582 25 the the DT cord-015021-pol2qm74 8582 26 lymphatics lymphatic NNS cord-015021-pol2qm74 8582 27 and and CC cord-015021-pol2qm74 8582 28 blood blood NN cord-015021-pol2qm74 8582 29 stream stream NN cord-015021-pol2qm74 8582 30 . . . cord-015021-pol2qm74 8583 1 These these DT cord-015021-pol2qm74 8583 2 activated activate VBN cord-015021-pol2qm74 8583 3 enzymes enzyme NNS cord-015021-pol2qm74 8583 4 escape escape VBP cord-015021-pol2qm74 8583 5 from from IN cord-015021-pol2qm74 8583 6 the the DT cord-015021-pol2qm74 8583 7 pancreas pancreas NN cord-015021-pol2qm74 8583 8 due due IN cord-015021-pol2qm74 8583 9 to to IN cord-015021-pol2qm74 8583 10 disruption disruption NN cord-015021-pol2qm74 8583 11 of of IN cord-015021-pol2qm74 8583 12 cells cell NNS cord-015021-pol2qm74 8583 13 with with IN cord-015021-pol2qm74 8583 14 associated associated JJ cord-015021-pol2qm74 8583 15 ischaemia ischaemia NN cord-015021-pol2qm74 8583 16 and and CC cord-015021-pol2qm74 8583 17 occasional occasional JJ cord-015021-pol2qm74 8583 18 infarction infarction NN cord-015021-pol2qm74 8583 19 of of IN cord-015021-pol2qm74 8583 20 tissue tissue NN cord-015021-pol2qm74 8583 21 . . . cord-015021-pol2qm74 8584 1 For for IN cord-015021-pol2qm74 8584 2 20 20 CD cord-015021-pol2qm74 8584 3 to to TO cord-015021-pol2qm74 8584 4 25 25 CD cord-015021-pol2qm74 8584 5 years year NNS cord-015021-pol2qm74 8584 6 it -PRON- PRP cord-015021-pol2qm74 8584 7 has have VBZ cord-015021-pol2qm74 8584 8 been be VBN cord-015021-pol2qm74 8584 9 postulated postulate VBN cord-015021-pol2qm74 8584 10 that that IN cord-015021-pol2qm74 8584 11 the the DT cord-015021-pol2qm74 8584 12 bocly bocly NNP cord-015021-pol2qm74 8584 13 's 's POS cord-015021-pol2qm74 8584 14 defence defence NN cord-015021-pol2qm74 8584 15 system system NN cord-015021-pol2qm74 8584 16 to to IN cord-015021-pol2qm74 8584 17 activated activate VBN cord-015021-pol2qm74 8584 18 pancreatic pancreatic JJ cord-015021-pol2qm74 8584 19 enzymes enzyme NNS cord-015021-pol2qm74 8584 20 required require VBD cord-015021-pol2qm74 8584 21 supplementation supplementation NN cord-015021-pol2qm74 8584 22 iu iu IN cord-015021-pol2qm74 8584 23 the the DT cord-015021-pol2qm74 8584 24 form form NN cord-015021-pol2qm74 8584 25 of of IN cord-015021-pol2qm74 8584 26 anti anti JJ cord-015021-pol2qm74 8584 27 - - JJ cord-015021-pol2qm74 8584 28 protease protease JJ cord-015021-pol2qm74 8584 29 support support NN cord-015021-pol2qm74 8584 30 either either CC cord-015021-pol2qm74 8584 31 in in IN cord-015021-pol2qm74 8584 32 the the DT cord-015021-pol2qm74 8584 33 vascular vascular JJ cord-015021-pol2qm74 8584 34 space space NN cord-015021-pol2qm74 8584 35 or or CC cord-015021-pol2qm74 8584 36 in in IN cord-015021-pol2qm74 8584 37 the the DT cord-015021-pol2qm74 8584 38 peritoneal peritoneal JJ cord-015021-pol2qm74 8584 39 cavity cavity NN cord-015021-pol2qm74 8584 40 . . . cord-015021-pol2qm74 8585 1 All all DT cord-015021-pol2qm74 8585 2 controlled control VBN cord-015021-pol2qm74 8585 3 studies study NNS cord-015021-pol2qm74 8585 4 have have VBP cord-015021-pol2qm74 8585 5 shown show VBN cord-015021-pol2qm74 8585 6 that that IN cord-015021-pol2qm74 8585 7 this this DT cord-015021-pol2qm74 8585 8 is be VBZ cord-015021-pol2qm74 8585 9 either either CC cord-015021-pol2qm74 8585 10 impracftcal impracftcal JJ cord-015021-pol2qm74 8585 11 or or CC cord-015021-pol2qm74 8585 12 unnecessary unnecessary JJ cord-015021-pol2qm74 8585 13 . . . cord-015021-pol2qm74 8586 1 Hore Hore NNP cord-015021-pol2qm74 8586 2 recently recently RB cord-015021-pol2qm74 8586 3 release release VBZ cord-015021-pol2qm74 8586 4 of of IN cord-015021-pol2qm74 8586 5 a a DT cord-015021-pol2qm74 8586 6 large large JJ cord-015021-pol2qm74 8586 7 number number NN cord-015021-pol2qm74 8586 8 of of IN cord-015021-pol2qm74 8586 9 cytokines cytokine NNS cord-015021-pol2qm74 8586 10 from from IN cord-015021-pol2qm74 8586 11 monocytes monocyte NNS cord-015021-pol2qm74 8586 12 , , , cord-015021-pol2qm74 8586 13 macrophages macrophage NNS cord-015021-pol2qm74 8586 14 and and CC cord-015021-pol2qm74 8586 15 neutrophils neutrophil NNS cord-015021-pol2qm74 8586 16 have have VBP cord-015021-pol2qm74 8586 17 been be VBN cord-015021-pol2qm74 8586 18 considered consider VBN cord-015021-pol2qm74 8586 19 to to TO cord-015021-pol2qm74 8586 20 be be VB cord-015021-pol2qm74 8586 21 harmful harmful JJ cord-015021-pol2qm74 8586 22 to to IN cord-015021-pol2qm74 8586 23 the the DT cord-015021-pol2qm74 8586 24 body body NN cord-015021-pol2qm74 8586 25 and and CC cord-015021-pol2qm74 8586 26 various various JJ cord-015021-pol2qm74 8586 27 agent~ agent~ NNP cord-015021-pol2qm74 8586 28 which which WDT cord-015021-pol2qm74 8586 29 oppose oppose VBP cord-015021-pol2qm74 8586 30 the the DT cord-015021-pol2qm74 8586 31 action action NN cord-015021-pol2qm74 8586 32 of of IN cord-015021-pol2qm74 8586 33 TNF TNF NNP cord-015021-pol2qm74 8586 34 alpha alpha NN cord-015021-pol2qm74 8586 35 , , , cord-015021-pol2qm74 8586 36 PAF PAF NNP cord-015021-pol2qm74 8586 37 and and CC cord-015021-pol2qm74 8586 38 similar similar JJ cord-015021-pol2qm74 8586 39 cytokines cytokine NNS cord-015021-pol2qm74 8586 40 are be VBP cord-015021-pol2qm74 8586 41 being be VBG cord-015021-pol2qm74 8586 42 examined examine VBN cord-015021-pol2qm74 8586 43 in in IN cord-015021-pol2qm74 8586 44 experimental experimental JJ cord-015021-pol2qm74 8586 45 anim anim NN cord-015021-pol2qm74 8586 46 ~ ~ NFP cord-015021-pol2qm74 8586 47 is be VBZ cord-015021-pol2qm74 8586 48 and and CC cord-015021-pol2qm74 8586 49 certain certain JJ cord-015021-pol2qm74 8586 50 clinical clinical JJ cord-015021-pol2qm74 8586 51 trials trial NNS cord-015021-pol2qm74 8586 52 , , , cord-015021-pol2qm74 8586 53 It -PRON- PRP cord-015021-pol2qm74 8586 54 has have VBZ cord-015021-pol2qm74 8586 55 clearly clearly RB cord-015021-pol2qm74 8586 56 been be VBN cord-015021-pol2qm74 8586 57 shown show VBN cord-015021-pol2qm74 8586 58 that that IN cord-015021-pol2qm74 8586 59 higher high JJR cord-015021-pol2qm74 8586 60 levels level NNS cord-015021-pol2qm74 8586 61 of of IN cord-015021-pol2qm74 8586 62 cytokines cytokine NNS cord-015021-pol2qm74 8586 63 are be VBP cord-015021-pol2qm74 8586 64 released release VBN cord-015021-pol2qm74 8586 65 in in IN cord-015021-pol2qm74 8586 66 the the DT cord-015021-pol2qm74 8586 67 patients patient NNS cord-015021-pol2qm74 8586 68 with with IN cord-015021-pol2qm74 8586 69 objectively objectively RB cord-015021-pol2qm74 8586 70 graded grade VBN cord-015021-pol2qm74 8586 71 severe severe JJ cord-015021-pol2qm74 8586 72 acute acute JJ cord-015021-pol2qm74 8586 73 pancreatitis pancreatitis NN cord-015021-pol2qm74 8586 74 than than IN cord-015021-pol2qm74 8586 75 in in IN cord-015021-pol2qm74 8586 76 those those DT cord-015021-pol2qm74 8586 77 with with IN cord-015021-pol2qm74 8586 78 milder mild JJR cord-015021-pol2qm74 8586 79 disease disease NN cord-015021-pol2qm74 8586 80 . . . cord-015021-pol2qm74 8587 1 We -PRON- PRP cord-015021-pol2qm74 8587 2 now now RB cord-015021-pol2qm74 8587 3 seem seem VBP cord-015021-pol2qm74 8587 4 to to TO cord-015021-pol2qm74 8587 5 be be VB cord-015021-pol2qm74 8587 6 moving move VBG cord-015021-pol2qm74 8587 7 into into IN cord-015021-pol2qm74 8587 8 an an DT cord-015021-pol2qm74 8587 9 exciting exciting JJ cord-015021-pol2qm74 8587 10 phase phase NN cord-015021-pol2qm74 8587 11 of of IN cord-015021-pol2qm74 8587 12 potentially potentially RB cord-015021-pol2qm74 8587 13 beneficial beneficial JJ cord-015021-pol2qm74 8587 14 therapy therapy NN cord-015021-pol2qm74 8587 15 in in IN cord-015021-pol2qm74 8587 16 acute acute JJ cord-015021-pol2qm74 8587 17 pancreatitis pancreatitis NN cord-015021-pol2qm74 8587 18 which which WDT cord-015021-pol2qm74 8587 19 has have VBZ cord-015021-pol2qm74 8587 20 had have VBN cord-015021-pol2qm74 8587 21 no no DT cord-015021-pol2qm74 8587 22 specific specific JJ cord-015021-pol2qm74 8587 23 effective effective JJ cord-015021-pol2qm74 8587 24 therapy therapy NN cord-015021-pol2qm74 8587 25 through through IN cord-015021-pol2qm74 8587 26 studies study NNS cord-015021-pol2qm74 8587 27 utilising utilise VBG cord-015021-pol2qm74 8587 28 aprotinin aprotinin NNP cord-015021-pol2qm74 8587 29 , , , cord-015021-pol2qm74 8587 30 gabexate gabexate NNP cord-015021-pol2qm74 8587 31 mesilate mesilate NNP cord-015021-pol2qm74 8587 32 and and CC cord-015021-pol2qm74 8587 33 fresh fresh JJ cord-015021-pol2qm74 8587 34 frozen frozen JJ cord-015021-pol2qm74 8587 35 plasma plasma NN cord-015021-pol2qm74 8587 36 . . . cord-015021-pol2qm74 8588 1 Inflammation inflammation NN cord-015021-pol2qm74 8588 2 cascades cascade NNS cord-015021-pol2qm74 8588 3 may may MD cord-015021-pol2qm74 8588 4 play play VB cord-015021-pol2qm74 8588 5 a a DT cord-015021-pol2qm74 8588 6 role role NN cord-015021-pol2qm74 8588 7 in in IN cord-015021-pol2qm74 8588 8 the the DT cord-015021-pol2qm74 8588 9 pathogenesis pathogenesis NN cord-015021-pol2qm74 8588 10 of of IN cord-015021-pol2qm74 8588 11 acute acute JJ cord-015021-pol2qm74 8588 12 pancreatitis pancreatitis NN cord-015021-pol2qm74 8588 13 . . . cord-015021-pol2qm74 8589 1 To to TO cord-015021-pol2qm74 8589 2 evaluate evaluate VB cord-015021-pol2qm74 8589 3 the the DT cord-015021-pol2qm74 8589 4 status status NN cord-015021-pol2qm74 8589 5 of of IN cord-015021-pol2qm74 8589 6 the the DT cord-015021-pol2qm74 8589 7 cellular cellular JJ cord-015021-pol2qm74 8589 8 immune immune JJ cord-015021-pol2qm74 8589 9 system system NN cord-015021-pol2qm74 8589 10 we -PRON- PRP cord-015021-pol2qm74 8589 11 examined examine VBD cord-015021-pol2qm74 8589 12 serum serum NN cord-015021-pol2qm74 8589 13 concentrations concentration NNS cord-015021-pol2qm74 8589 14 of of IN cord-015021-pol2qm74 8589 15 immune immune JJ cord-015021-pol2qm74 8589 16 activation activation NN cord-015021-pol2qm74 8589 17 markers marker NNS cord-015021-pol2qm74 8589 18 in in IN cord-015021-pol2qm74 8589 19 24 24 CD cord-015021-pol2qm74 8589 20 patients patient NNS cord-015021-pol2qm74 8589 21 with with IN cord-015021-pol2qm74 8589 22 acute acute JJ cord-015021-pol2qm74 8589 23 pancreatitis pancreatitis NN cord-015021-pol2qm74 8589 24 ( ( -LRB- cord-015021-pol2qm74 8589 25 14 14 CD cord-015021-pol2qm74 8589 26 males male NNS cord-015021-pol2qm74 8589 27 , , , cord-015021-pol2qm74 8589 28 10 10 CD cord-015021-pol2qm74 8589 29 females female NNS cord-015021-pol2qm74 8589 30 ; ; : cord-015021-pol2qm74 8589 31 median median JJ cord-015021-pol2qm74 8589 32 age age NN cord-015021-pol2qm74 8589 33 : : : cord-015021-pol2qm74 8589 34 56 56 CD cord-015021-pol2qm74 8589 35 years year NNS cord-015021-pol2qm74 8589 36 , , , cord-015021-pol2qm74 8589 37 range range NN cord-015021-pol2qm74 8589 38 : : : cord-015021-pol2qm74 8589 39 32 32 CD cord-015021-pol2qm74 8589 40 - - SYM cord-015021-pol2qm74 8589 41 81 81 CD cord-015021-pol2qm74 8589 42 years year NNS cord-015021-pol2qm74 8589 43 ) ) -RRB- cord-015021-pol2qm74 8589 44 . . . cord-015021-pol2qm74 8590 1 Concentrations concentration NNS cord-015021-pol2qm74 8590 2 of of IN cord-015021-pol2qm74 8590 3 neopterin neopterin NNP cord-015021-pol2qm74 8590 4 , , , cord-015021-pol2qm74 8590 5 serum serum NN cord-015021-pol2qm74 8590 6 soluble soluble JJ cord-015021-pol2qm74 8590 7 tumor tumor NN cord-015021-pol2qm74 8590 8 necrosis necrosis NN cord-015021-pol2qm74 8590 9 factor factor NN cord-015021-pol2qm74 8590 10 receptor receptor NN cord-015021-pol2qm74 8590 11 ( ( -LRB- cord-015021-pol2qm74 8590 12 sTNF stnf NN cord-015021-pol2qm74 8590 13 - - HYPH cord-015021-pol2qm74 8590 14 R r NN cord-015021-pol2qm74 8590 15 ) ) -RRB- cord-015021-pol2qm74 8590 16 and and CC cord-015021-pol2qm74 8590 17 serum serum NN cord-015021-pol2qm74 8590 18 soluble soluble JJ cord-015021-pol2qm74 8590 19 intercellular intercellular JJ cord-015021-pol2qm74 8590 20 adhesion adhesion NN cord-015021-pol2qm74 8590 21 molecule molecule NN cord-015021-pol2qm74 8590 22 type type NN cord-015021-pol2qm74 8590 23 1 1 CD cord-015021-pol2qm74 8590 24 ( ( -LRB- cord-015021-pol2qm74 8590 25 slCAM-1 slCAM-1 NNP cord-015021-pol2qm74 8590 26 ) ) -RRB- cord-015021-pol2qm74 8590 27 were be VBD cord-015021-pol2qm74 8590 28 determined determine VBN cord-015021-pol2qm74 8590 29 using use VBG cord-015021-pol2qm74 8590 30 immunoassays immunoassay NNS cord-015021-pol2qm74 8590 31 ( ( -LRB- cord-015021-pol2qm74 8590 32 Henning Henning NNP cord-015021-pol2qm74 8590 33 , , , cord-015021-pol2qm74 8590 34 Bender Bender NNP cord-015021-pol2qm74 8590 35 , , , cord-015021-pol2qm74 8590 36 T T NNP cord-015021-pol2qm74 8590 37 Cell Cell NNP cord-015021-pol2qm74 8590 38 Sciences Sciences NNPS cord-015021-pol2qm74 8590 39 ) ) -RRB- cord-015021-pol2qm74 8590 40 . . . cord-015021-pol2qm74 8591 1 13/14 13/14 CD cord-015021-pol2qm74 8591 2 had have VBD cord-015021-pol2qm74 8591 3 increased increase VBN cord-015021-pol2qm74 8591 4 concentrations concentration NNS cord-015021-pol2qm74 8591 5 of of IN cord-015021-pol2qm74 8591 6 sTNF stnf NN cord-015021-pol2qm74 8591 7 - - HYPH cord-015021-pol2qm74 8591 8 R r NN cord-015021-pol2qm74 8591 9 compared compare VBN cord-015021-pol2qm74 8591 10 to to IN cord-015021-pol2qm74 8591 11 the the DT cord-015021-pol2qm74 8591 12 75th 75th JJ cord-015021-pol2qm74 8591 13 percentile percentile NN cord-015021-pol2qm74 8591 14 obtained obtain VBN cord-015021-pol2qm74 8591 15 in in IN cord-015021-pol2qm74 8591 16 healthy healthy JJ cord-015021-pol2qm74 8591 17 controls control NNS cord-015021-pol2qm74 8591 18 ( ( -LRB- cord-015021-pol2qm74 8591 19 > > NFP cord-015021-pol2qm74 8591 20 4.2 4.2 CD cord-015021-pol2qm74 8591 21 ng ng NNP cord-015021-pol2qm74 8591 22 / / SYM cord-015021-pol2qm74 8591 23 ml ml NN cord-015021-pol2qm74 8591 24 ) ) -RRB- cord-015021-pol2qm74 8591 25 , , , cord-015021-pol2qm74 8591 26 and and CC cord-015021-pol2qm74 8591 27 9/24 9/24 CD cord-015021-pol2qm74 8591 28 patients patient NNS cord-015021-pol2qm74 8591 29 had have VBD cord-015021-pol2qm74 8591 30 increased increase VBN cord-015021-pol2qm74 8591 31 neopterin neopterin NNP cord-015021-pol2qm74 8591 32 ( ( -LRB- cord-015021-pol2qm74 8591 33 > > NFP cord-015021-pol2qm74 8591 34 8.7 8.7 CD cord-015021-pol2qm74 8591 35 nmol nmol NN cord-015021-pol2qm74 8591 36 / / , cord-015021-pol2qm74 8591 37 I i NN cord-015021-pol2qm74 8591 38 ) ) -RRB- cord-015021-pol2qm74 8591 39 , , , cord-015021-pol2qm74 8591 40 9/24 9/24 CD cord-015021-pol2qm74 8591 41 presented present VBN cord-015021-pol2qm74 8591 42 with with IN cord-015021-pol2qm74 8591 43 elevated elevate VBN cord-015021-pol2qm74 8591 44 slCAM-1 slCAM-1 NNP cord-015021-pol2qm74 8591 45 ( ( -LRB- cord-015021-pol2qm74 8591 46 > > XX cord-015021-pol2qm74 8592 1 440 440 CD cord-015021-pol2qm74 8592 2 U u NN cord-015021-pol2qm74 8592 3 / / SYM cord-015021-pol2qm74 8592 4 I i NN cord-015021-pol2qm74 8592 5 ) ) -RRB- cord-015021-pol2qm74 8592 6 . . . cord-015021-pol2qm74 8593 1 All all DT cord-015021-pol2qm74 8593 2 patients patient NNS cord-015021-pol2qm74 8593 3 with with IN cord-015021-pol2qm74 8593 4 increased increase VBN cord-015021-pol2qm74 8593 5 neopterin neopterin NNP cord-015021-pol2qm74 8593 6 also also RB cord-015021-pol2qm74 8593 7 had have VBD cord-015021-pol2qm74 8593 8 increased increase VBN cord-015021-pol2qm74 8593 9 sTNF stnf NN cord-015021-pol2qm74 8593 10 - - HYPH cord-015021-pol2qm74 8593 11 R r NN cord-015021-pol2qm74 8593 12 , , , cord-015021-pol2qm74 8594 1 4 4 CD cord-015021-pol2qm74 8594 2 patients patient NNS cord-015021-pol2qm74 8594 3 had have VBD cord-015021-pol2qm74 8594 4 concentrations concentration NNS cord-015021-pol2qm74 8594 5 of of IN cord-015021-pol2qm74 8594 6 all all DT cord-015021-pol2qm74 8594 7 three three CD cord-015021-pol2qm74 8594 8 markers marker NNS cord-015021-pol2qm74 8594 9 outside outside IN cord-015021-pol2qm74 8594 10 the the DT cord-015021-pol2qm74 8594 11 normal normal JJ cord-015021-pol2qm74 8594 12 range range NN cord-015021-pol2qm74 8594 13 . . . cord-015021-pol2qm74 8595 1 There there EX cord-015021-pol2qm74 8595 2 existed exist VBD cord-015021-pol2qm74 8595 3 a a DT cord-015021-pol2qm74 8595 4 significant significant JJ cord-015021-pol2qm74 8595 5 correlation correlation NN cord-015021-pol2qm74 8595 6 between between IN cord-015021-pol2qm74 8595 7 neopterin neopterin NNP cord-015021-pol2qm74 8595 8 and and CC cord-015021-pol2qm74 8595 9 sTNF stnf NN cord-015021-pol2qm74 8595 10 - - HYPH cord-015021-pol2qm74 8595 11 R r NN cord-015021-pol2qm74 8595 12 ( ( -LRB- cord-015021-pol2qm74 8595 13 rs rs NN cord-015021-pol2qm74 8595 14 = = SYM cord-015021-pol2qm74 8595 15 0.728 0.728 CD cord-015021-pol2qm74 8595 16 , , , cord-015021-pol2qm74 8595 17 p p NN cord-015021-pol2qm74 8595 18 < < XX cord-015021-pol2qm74 8595 19 0.001 0.001 CD cord-015021-pol2qm74 8595 20 ) ) -RRB- cord-015021-pol2qm74 8595 21 . . . cord-015021-pol2qm74 8596 1 Weak weak JJ cord-015021-pol2qm74 8596 2 associations association NNS cord-015021-pol2qm74 8596 3 between between IN cord-015021-pol2qm74 8596 4 age age NN cord-015021-pol2qm74 8596 5 and and CC cord-015021-pol2qm74 8596 6 sTNF stnf NN cord-015021-pol2qm74 8596 7 - - HYPH cord-015021-pol2qm74 8596 8 R r NN cord-015021-pol2qm74 8596 9 ( ( -LRB- cord-015021-pol2qm74 8596 10 rs=0.435 rs=0.435 NNS cord-015021-pol2qm74 8596 11 , , , cord-015021-pol2qm74 8596 12 p p NN cord-015021-pol2qm74 8596 13 = = SYM cord-015021-pol2qm74 8596 14 O.05 o.05 NN cord-015021-pol2qm74 8596 15 ) ) -RRB- cord-015021-pol2qm74 8596 16 or or CC cord-015021-pol2qm74 8596 17 neopterin neopterin NNP cord-015021-pol2qm74 8596 18 ( ( -LRB- cord-015021-pol2qm74 8596 19 rs=0.456 rs=0.456 NNP cord-015021-pol2qm74 8596 20 , , , cord-015021-pol2qm74 8596 21 p p NN cord-015021-pol2qm74 8596 22 = = SYM cord-015021-pol2qm74 8596 23 0.044 0.044 CD cord-015021-pol2qm74 8596 24 ) ) -RRB- cord-015021-pol2qm74 8596 25 were be VBD cord-015021-pol2qm74 8596 26 also also RB cord-015021-pol2qm74 8596 27 found find VBN cord-015021-pol2qm74 8596 28 . . . cord-015021-pol2qm74 8597 1 Our -PRON- PRP$ cord-015021-pol2qm74 8597 2 results result NNS cord-015021-pol2qm74 8597 3 demonstrate demonstrate VBP cord-015021-pol2qm74 8597 4 activation activation NN cord-015021-pol2qm74 8597 5 of of IN cord-015021-pol2qm74 8597 6 the the DT cord-015021-pol2qm74 8597 7 cell cell NN cord-015021-pol2qm74 8597 8 - - HYPH cord-015021-pol2qm74 8597 9 mediated mediate VBN cord-015021-pol2qm74 8597 10 immune immune JJ cord-015021-pol2qm74 8597 11 system system NN cord-015021-pol2qm74 8597 12 taking take VBG cord-015021-pol2qm74 8597 13 place place NN cord-015021-pol2qm74 8597 14 in in IN cord-015021-pol2qm74 8597 15 a a DT cord-015021-pol2qm74 8597 16 sub sub NN cord-015021-pol2qm74 8597 17 - - JJ cord-015021-pol2qm74 8597 18 group group NN cord-015021-pol2qm74 8597 19 of of IN cord-015021-pol2qm74 8597 20 patients patient NNS cord-015021-pol2qm74 8597 21 with with IN cord-015021-pol2qm74 8597 22 acute acute JJ cord-015021-pol2qm74 8597 23 pancreatitis pancreatitis NN cord-015021-pol2qm74 8597 24 . . . cord-015021-pol2qm74 8598 1 The the DT cord-015021-pol2qm74 8598 2 finding finding NN cord-015021-pol2qm74 8598 3 of of IN cord-015021-pol2qm74 8598 4 increased increase VBN cord-015021-pol2qm74 8598 5 neopterin neopterin JJ cord-015021-pol2qm74 8598 6 and and CC cord-015021-pol2qm74 8598 7 sTNF stnf NN cord-015021-pol2qm74 8598 8 - - HYPH cord-015021-pol2qm74 8598 9 R r NN cord-015021-pol2qm74 8598 10 levels level NNS cord-015021-pol2qm74 8598 11 implies imply VBZ cord-015021-pol2qm74 8598 12 that that IN cord-015021-pol2qm74 8598 13 activated activate VBN cord-015021-pol2qm74 8598 14 monocytes monocyte NNS cord-015021-pol2qm74 8598 15 / / SYM cord-015021-pol2qm74 8598 16 macrophages macrophage NNS cord-015021-pol2qm74 8598 17 are be VBP cord-015021-pol2qm74 8598 18 involved involve VBN cord-015021-pol2qm74 8598 19 in in IN cord-015021-pol2qm74 8598 20 the the DT cord-015021-pol2qm74 8598 21 pathogenesis pathogenesis NN cord-015021-pol2qm74 8598 22 of of IN cord-015021-pol2qm74 8598 23 the the DT cord-015021-pol2qm74 8598 24 disease disease NN cord-015021-pol2qm74 8598 25 . . . cord-015021-pol2qm74 8599 1 Further further JJ cord-015021-pol2qm74 8599 2 data datum NNS cord-015021-pol2qm74 8599 3 are be VBP cord-015021-pol2qm74 8599 4 necessary necessary JJ cord-015021-pol2qm74 8599 5 to to TO cord-015021-pol2qm74 8599 6 evaluate evaluate VB cord-015021-pol2qm74 8599 7 potential potential JJ cord-015021-pol2qm74 8599 8 associations association NNS cord-015021-pol2qm74 8599 9 between between IN cord-015021-pol2qm74 8599 10 changes change NNS cord-015021-pol2qm74 8599 11 of of IN cord-015021-pol2qm74 8599 12 marker marker NN cord-015021-pol2qm74 8599 13 concent concent NN cord-015021-pol2qm74 8599 14 - - HYPH cord-015021-pol2qm74 8599 15 rations ration NNS cord-015021-pol2qm74 8599 16 and and CC cord-015021-pol2qm74 8599 17 the the DT cord-015021-pol2qm74 8599 18 course course NN cord-015021-pol2qm74 8599 19 of of IN cord-015021-pol2qm74 8599 20 the the DT cord-015021-pol2qm74 8599 21 disease disease NN cord-015021-pol2qm74 8599 22 . . . cord-015021-pol2qm74 8600 1 Pancreatic pancreatic JJ cord-015021-pol2qm74 8600 2 injury injury NN cord-015021-pol2qm74 8600 3 after after IN cord-015021-pol2qm74 8600 4 heart heart NN cord-015021-pol2qm74 8600 5 surgery surgery NN cord-015021-pol2qm74 8600 6 was be VBD cord-015021-pol2qm74 8600 7 reported report VBN cord-015021-pol2qm74 8600 8 as as RB cord-015021-pol2qm74 8600 9 soon soon RB cord-015021-pol2qm74 8600 10 as as IN cord-015021-pol2qm74 8600 11 1970 1970 CD cord-015021-pol2qm74 8600 12 ( ( -LRB- cord-015021-pol2qm74 8600 13 1,2 1,2 CD cord-015021-pol2qm74 8600 14 ) ) -RRB- cord-015021-pol2qm74 8600 15 and and CC cord-015021-pol2qm74 8600 16 characterized characterize VBN cord-015021-pol2qm74 8600 17 by by IN cord-015021-pol2qm74 8600 18 increased increase VBN cord-015021-pol2qm74 8600 19 serum serum NN cord-015021-pol2qm74 8600 20 or or CC cord-015021-pol2qm74 8600 21 urine urine NN cord-015021-pol2qm74 8600 22 amylase amylase NN cord-015021-pol2qm74 8600 23 levels level NNS cord-015021-pol2qm74 8600 24 ( ( -LRB- cord-015021-pol2qm74 8600 25 in in IN cord-015021-pol2qm74 8600 26 about about RB cord-015021-pol2qm74 8600 27 33 33 CD cord-015021-pol2qm74 8600 28 % % NN cord-015021-pol2qm74 8600 29 of of IN cord-015021-pol2qm74 8600 30 patients patient NNS cord-015021-pol2qm74 8600 31 ) ) -RRB- cord-015021-pol2qm74 8600 32 in in IN cord-015021-pol2qm74 8600 33 the the DT cord-015021-pol2qm74 8600 34 5 5 CD cord-015021-pol2qm74 8600 35 fi fi NN cord-015021-pol2qm74 8600 36 ~ ~ NN cord-015021-pol2qm74 8600 37 t t NNP cord-015021-pol2qm74 8600 38 postoperafi postoperafi NNP cord-015021-pol2qm74 8600 39 . . . cord-015021-pol2qm74 8601 1 ' ' `` cord-015021-pol2qm74 8601 2 ve ve NNP cord-015021-pol2qm74 8601 3 days day NNS cord-015021-pol2qm74 8601 4 . . . cord-015021-pol2qm74 8602 1 This this DT cord-015021-pol2qm74 8602 2 pancreatic pancreatic JJ cord-015021-pol2qm74 8602 3 injury injury NN cord-015021-pol2qm74 8602 4 , , , cord-015021-pol2qm74 8602 5 which which WDT cord-015021-pol2qm74 8602 6 sometimes sometimes RB cord-015021-pol2qm74 8602 7 led lead VBD cord-015021-pol2qm74 8602 8 to to IN cord-015021-pol2qm74 8602 9 acute acute JJ cord-015021-pol2qm74 8602 10 pancreatitis pancreatitis NN cord-015021-pol2qm74 8602 11 , , , cord-015021-pol2qm74 8602 12 was be VBD cord-015021-pol2qm74 8602 13 atreaay atreaay NNP cord-015021-pol2qm74 8602 14 at at IN cord-015021-pol2qm74 8602 15 ~ ~ NFP cord-015021-pol2qm74 8602 16 buted bute VBN cord-015021-pol2qm74 8602 17 to to IN cord-015021-pol2qm74 8602 18 inappropriate inappropriate JJ cord-015021-pol2qm74 8602 19 perfusion perfusion NN cord-015021-pol2qm74 8602 20 of of IN cord-015021-pol2qm74 8602 21 this this DT cord-015021-pol2qm74 8602 22 organ organ NN cord-015021-pol2qm74 8602 23 . . . cord-015021-pol2qm74 8603 1 In in IN cord-015021-pol2qm74 8603 2 the the DT cord-015021-pol2qm74 8603 3 198ffs 198ffs CD cord-015021-pol2qm74 8603 4 , , , cord-015021-pol2qm74 8603 5 3 3 CD cord-015021-pol2qm74 8603 6 studies study NNS cord-015021-pol2qm74 8603 7 were be VBD cord-015021-pol2qm74 8603 8 published publish VBN cord-015021-pol2qm74 8603 9 dealing deal VBG cord-015021-pol2qm74 8603 10 with with IN cord-015021-pol2qm74 8603 11 pancreatic pancreatic JJ cord-015021-pol2qm74 8603 12 suffering suffering NN cord-015021-pol2qm74 8603 13 alter alter VB cord-015021-pol2qm74 8603 14 heart heart NN cord-015021-pol2qm74 8603 15 surgery surgery NN cord-015021-pol2qm74 8603 16 , , , cord-015021-pol2qm74 8603 17 in in IN cord-015021-pol2qm74 8603 18 large large JJ cord-015021-pol2qm74 8603 19 series series NN cord-015021-pol2qm74 8603 20 of of IN cord-015021-pol2qm74 8603 21 patients patient NNS cord-015021-pol2qm74 8603 22 , , , cord-015021-pol2qm74 8603 23 concluding conclude VBG cord-015021-pol2qm74 8603 24 ~n ~n NNP cord-015021-pol2qm74 8604 1 ~at ~at NNP cord-015021-pol2qm74 8604 2 panc panc NNP cord-015021-pol2qm74 8604 3 ~ ~ NFP cord-015021-pol2qm74 8604 4 a a LS cord-015021-pol2qm74 8604 5 ~ ~ NFP cord-015021-pol2qm74 8604 6 c c NN cord-015021-pol2qm74 8604 7 injury injury NN cord-015021-pol2qm74 8604 8 ( ( -LRB- cord-015021-pol2qm74 8604 9 with with IN cord-015021-pol2qm74 8604 10 a a DT cord-015021-pol2qm74 8604 11 low low JJ cord-015021-pol2qm74 8604 12 incidence incidence NN cord-015021-pol2qm74 8604 13 of of IN cord-015021-pol2qm74 8604 14 pancreatifis pancreatifis NN cord-015021-pol2qm74 8604 15 ) ) -RRB- cord-015021-pol2qm74 8604 16 is be VBZ cord-015021-pol2qm74 8604 17 more more RBR cord-015021-pol2qm74 8604 18 common common JJ cord-015021-pol2qm74 8604 19 than than IN cord-015021-pol2qm74 8604 20 previously previously RB cord-015021-pol2qm74 8604 21 recognized recognize VBN cord-015021-pol2qm74 8604 22 and and CC cord-015021-pol2qm74 8604 23 is be VBZ cord-015021-pol2qm74 8604 24 a a DT cord-015021-pol2qm74 8604 25 potential potential JJ cord-015021-pol2qm74 8604 26 source source NN cord-015021-pol2qm74 8604 27 of of IN cord-015021-pol2qm74 8604 28 complication complication NN cord-015021-pol2qm74 8604 29 after after IN cord-015021-pol2qm74 8604 30 camliac camliac NNP cord-015021-pol2qm74 8604 31 surgery surgery NN cord-015021-pol2qm74 8604 32 ( ( -LRB- cord-015021-pol2qm74 8604 33 3 3 CD cord-015021-pol2qm74 8604 34 , , , cord-015021-pol2qm74 8604 35 4 4 CD cord-015021-pol2qm74 8604 36 , , , cord-015021-pol2qm74 8604 37 5 5 CD cord-015021-pol2qm74 8604 38 ) ) -RRB- cord-015021-pol2qm74 8604 39 . . . cord-015021-pol2qm74 8605 1 In in IN cord-015021-pol2qm74 8605 2 a a DT cord-015021-pol2qm74 8605 3 recent recent JJ cord-015021-pol2qm74 8605 4 study study NN cord-015021-pol2qm74 8605 5 ( ( -LRB- cord-015021-pol2qm74 8605 6 6 6 CD cord-015021-pol2qm74 8605 7 ) ) -RRB- cord-015021-pol2qm74 8605 8 , , , cord-015021-pol2qm74 8605 9 evidence evidence NN cord-015021-pol2qm74 8605 10 of of IN cord-015021-pol2qm74 8605 11 pancreatic pancreatic JJ cord-015021-pol2qm74 8605 12 cellular cellular JJ cord-015021-pol2qm74 8605 13 injury injury NN cord-015021-pol2qm74 8605 14 was be VBD cord-015021-pol2qm74 8605 15 found find VBN cord-015021-pol2qm74 8605 16 in in IN cord-015021-pol2qm74 8605 17 80 80 CD cord-015021-pol2qm74 8605 18 out out IN cord-015021-pol2qm74 8605 19 of of IN cord-015021-pol2qm74 8605 20 300 300 CD cord-015021-pol2qm74 8605 21 patients patient NNS cord-015021-pol2qm74 8605 22 undergoing undergo VBG cord-015021-pol2qm74 8605 23 cardiac cardiac JJ cord-015021-pol2qm74 8605 24 surgery surgery NN cord-015021-pol2qm74 8605 25 , , , cord-015021-pol2qm74 8605 26 with with IN cord-015021-pol2qm74 8605 27 22 22 CD cord-015021-pol2qm74 8605 28 out out IN cord-015021-pol2qm74 8605 29 of of IN cord-015021-pol2qm74 8605 30 these these DT cord-015021-pol2qm74 8605 31 80 80 CD cord-015021-pol2qm74 8605 32 patients patient NNS cord-015021-pol2qm74 8605 33 presenting present VBG cord-015021-pol2qm74 8605 34 abdominal abdominal JJ cord-015021-pol2qm74 8605 35 signs sign NNS cord-015021-pol2qm74 8605 36 or or CC cord-015021-pol2qm74 8605 37 symptoms symptom NNS cord-015021-pol2qm74 8605 38 and and CC cord-015021-pol2qm74 8605 39 3 3 CD cord-015021-pol2qm74 8605 40 developing develop VBG cord-015021-pol2qm74 8605 41 severe severe JJ cord-015021-pol2qm74 8605 42 pancreafitis pancreafitis NN cord-015021-pol2qm74 8605 43 . . . cord-015021-pol2qm74 8606 1 This this DT cord-015021-pol2qm74 8606 2 injury injury NN cord-015021-pol2qm74 8606 3 was be VBD cord-015021-pol2qm74 8606 4 associated associate VBN cord-015021-pol2qm74 8606 5 w w NN cord-015021-pol2qm74 8606 6 ~ ~ NFP cord-015021-pol2qm74 8606 7 th th DT cord-015021-pol2qm74 8606 8 preoperative preoperative JJ cord-015021-pol2qm74 8606 9 renal renal JJ cord-015021-pol2qm74 8606 10 insufficiency insufficiency NN cord-015021-pol2qm74 8606 11 , , , cord-015021-pol2qm74 8606 12 valve valve NN cord-015021-pol2qm74 8606 13 surgery surgery NN cord-015021-pol2qm74 8606 14 , , , cord-015021-pol2qm74 8606 15 ~ ~ NFP cord-015021-pol2qm74 8606 16 .. .. NFP cord-015021-pol2qm74 8606 17 stoperalive stoperalive NNP cord-015021-pol2qm74 8606 18 hytxXension hytxXension NNP cord-015021-pol2qm74 8606 19 , , , cord-015021-pol2qm74 8606 20 calcium calcium NN cord-015021-pol2qm74 8606 21 administered administer VBN cord-015021-pol2qm74 8606 22 periopuratively periopuratively RB cord-015021-pol2qm74 8606 23 and and CC cord-015021-pol2qm74 8606 24 length length NN cord-015021-pol2qm74 8606 25 of of IN cord-015021-pol2qm74 8606 26 bypass bypass NN cord-015021-pol2qm74 8606 27 . . . cord-015021-pol2qm74 8607 1 We -PRON- PRP cord-015021-pol2qm74 8607 2 studied study VBD cord-015021-pol2qm74 8607 3 300 300 CD cord-015021-pol2qm74 8607 4 patients patient NNS cord-015021-pol2qm74 8607 5 submitted submit VBN cord-015021-pol2qm74 8607 6 to to IN cord-015021-pol2qm74 8607 7 cardiopulmunary cardiopulmunary NNP cord-015021-pol2qm74 8607 8 bypass bypass NNP cord-015021-pol2qm74 8607 9 ( ( -LRB- cord-015021-pol2qm74 8607 10 CPB CPB NNP cord-015021-pol2qm74 8607 11 ) ) -RRB- cord-015021-pol2qm74 8607 12 for for IN cord-015021-pol2qm74 8607 13 heart heart NN cord-015021-pol2qm74 8607 14 surgery surgery NN cord-015021-pol2qm74 8607 15 and and CC cord-015021-pol2qm74 8607 16 used use VBD cord-015021-pol2qm74 8607 17 the the DT cord-015021-pol2qm74 8607 18 measurement measurement NN cord-015021-pol2qm74 8607 19 of of IN cord-015021-pol2qm74 8607 20 uN:~sin uN:~sin NNP cord-015021-pol2qm74 8607 21 , , , cord-015021-pol2qm74 8607 22 pancreatic pancreatic JJ cord-015021-pol2qm74 8607 23 iso iso NN cord-015021-pol2qm74 8607 24 - - HYPH cord-015021-pol2qm74 8607 25 amylase amylase NN cord-015021-pol2qm74 8607 26 and and CC cord-015021-pol2qm74 8607 27 lipase lipase NN cord-015021-pol2qm74 8607 28 in in IN cord-015021-pol2qm74 8607 29 plasma plasma NN cord-015021-pol2qm74 8607 30 for for IN cord-015021-pol2qm74 8607 31 biochemical biochemical JJ cord-015021-pol2qm74 8607 32 characterization characterization NN cord-015021-pol2qm74 8607 33 of of IN cord-015021-pol2qm74 8607 34 pancreatic pancreatic JJ cord-015021-pol2qm74 8607 35 cellular cellular JJ cord-015021-pol2qm74 8607 36 injury injury NN cord-015021-pol2qm74 8607 37 . . . cord-015021-pol2qm74 8608 1 Blood blood NN cord-015021-pol2qm74 8608 2 samples sample NNS cord-015021-pol2qm74 8608 3 were be VBD cord-015021-pol2qm74 8608 4 obtained obtain VBN cord-015021-pol2qm74 8608 5 before before IN cord-015021-pol2qm74 8608 6 surgery surgery NN cord-015021-pol2qm74 8608 7 , , , cord-015021-pol2qm74 8608 8 directly directly RB cord-015021-pol2qm74 8608 9 aller aller NNP cord-015021-pol2qm74 8608 10 surgery surgery NN cord-015021-pol2qm74 8609 1 ( ( -LRB- cord-015021-pol2qm74 8609 2 return return VB cord-015021-pol2qm74 8609 3 to to IN cord-015021-pol2qm74 8609 4 inte inte NNP cord-015021-pol2qm74 8609 5 ~ ~ NFP cord-015021-pol2qm74 8609 6 ve ve NNP cord-015021-pol2qm74 8609 7 care care NNP cord-015021-pol2qm74 8609 8 unit unit NN cord-015021-pol2qm74 8609 9 ) ) -RRB- cord-015021-pol2qm74 8609 10 , , , cord-015021-pol2qm74 8609 11 8 8 CD cord-015021-pol2qm74 8609 12 hours hour NNS cord-015021-pol2qm74 8609 13 alter alter VBP cord-015021-pol2qm74 8609 14 surgery surgery NN cord-015021-pol2qm74 8609 15 and and CC cord-015021-pol2qm74 8609 16 in in IN cord-015021-pol2qm74 8609 17 the the DT cord-015021-pol2qm74 8609 18 folfowing folfowe VBG cord-015021-pol2qm74 8609 19 days day NNS cord-015021-pol2qm74 8609 20 alter alter VBP cord-015021-pol2qm74 8609 21 surgery surgery NN cord-015021-pol2qm74 8609 22 ( ( -LRB- cord-015021-pol2qm74 8609 23 days day NNS cord-015021-pol2qm74 8609 24 1 1 CD cord-015021-pol2qm74 8609 25 , , , cord-015021-pol2qm74 8609 26 2 2 CD cord-015021-pol2qm74 8609 27 , , , cord-015021-pol2qm74 8609 28 3 3 CD cord-015021-pol2qm74 8609 29 , , , cord-015021-pol2qm74 8609 30 4 4 CD cord-015021-pol2qm74 8609 31 and and CC cord-015021-pol2qm74 8609 32 8) 8) NN cord-015021-pol2qm74 8609 33 . . . cord-015021-pol2qm74 8610 1 Computed compute VBN cord-015021-pol2qm74 8610 2 tomography tomography NN cord-015021-pol2qm74 8610 3 scan scan NN cord-015021-pol2qm74 8610 4 of of IN cord-015021-pol2qm74 8610 5 pancreas pancreas NN cord-015021-pol2qm74 8610 6 was be VBD cord-015021-pol2qm74 8610 7 performed perform VBN cord-015021-pol2qm74 8610 8 in in IN cord-015021-pol2qm74 8610 9 patients patient NNS cord-015021-pol2qm74 8610 10 presenting present VBG cord-015021-pol2qm74 8610 11 hi~ hi~ JJ cord-015021-pol2qm74 8610 12 levels level NNS cord-015021-pol2qm74 8610 13 of of IN cord-015021-pol2qm74 8610 14 amylase amylase NN cord-015021-pol2qm74 8610 15 on on IN cord-015021-pol2qm74 8610 16 day day NN cord-015021-pol2qm74 8610 17 1 1 CD cord-015021-pol2qm74 8610 18 . . . cord-015021-pol2qm74 8611 1 We -PRON- PRP cord-015021-pol2qm74 8611 2 measured measure VBD cord-015021-pol2qm74 8611 3 abnormal abnormal JJ cord-015021-pol2qm74 8611 4 levels level NNS cord-015021-pol2qm74 8611 5 of of IN cord-015021-pol2qm74 8611 6 trypsin trypsin NN cord-015021-pol2qm74 8611 7 and and CC cord-015021-pol2qm74 8611 8 pancTeatic pancteatic JJ cord-015021-pol2qm74 8611 9 iso iso NN cord-015021-pol2qm74 8611 10 - - HYPH cord-015021-pol2qm74 8611 11 amylase amylase NN cord-015021-pol2qm74 8611 12 in in IN cord-015021-pol2qm74 8611 13 30 30 CD cord-015021-pol2qm74 8611 14 % % NN cord-015021-pol2qm74 8611 15 of of IN cord-015021-pol2qm74 8611 16 patients patient NNS cord-015021-pol2qm74 8611 17 and and CC cord-015021-pol2qm74 8611 18 observed observe VBD cord-015021-pol2qm74 8611 19 2 2 CD cord-015021-pol2qm74 8611 20 simultaneous simultaneous JJ cord-015021-pol2qm74 8611 21 releases release NNS cord-015021-pol2qm74 8611 22 of of IN cord-015021-pol2qm74 8611 23 these these DT cord-015021-pol2qm74 8611 24 2 2 CD cord-015021-pol2qm74 8611 25 enzymes enzyme NNS cord-015021-pol2qm74 8611 26 , , , cord-015021-pol2qm74 8611 27 the the DT cord-015021-pol2qm74 8611 28 fi,'st fi,'st NNP cord-015021-pol2qm74 8611 29 one one CD cord-015021-pol2qm74 8611 30 in in IN cord-015021-pol2qm74 8611 31 the the DT cord-015021-pol2qm74 8611 32 24 24 CD cord-015021-pol2qm74 8611 33 hours hour NNS cord-015021-pol2qm74 8611 34 after after IN cord-015021-pol2qm74 8611 35 surgery surgery NN cord-015021-pol2qm74 8611 36 and and CC cord-015021-pol2qm74 8611 37 the the DT cord-015021-pol2qm74 8611 38 second second JJ cord-015021-pol2qm74 8611 39 more more RBR cord-015021-pol2qm74 8611 40 intense intense JJ cord-015021-pol2qm74 8611 41 from from IN cord-015021-pol2qm74 8611 42 day day NN cord-015021-pol2qm74 8611 43 4 4 CD cord-015021-pol2qm74 8611 44 and and CC cord-015021-pol2qm74 8611 45 pa pa NNP cord-015021-pol2qm74 8611 46 ~ ~ NFP cord-015021-pol2qm74 8611 47 icularly icularly RB cord-015021-pol2qm74 8611 48 on on IN cord-015021-pol2qm74 8611 49 day day NN cord-015021-pol2qm74 8611 50 8 8 CD cord-015021-pol2qm74 8611 51 after after IN cord-015021-pol2qm74 8611 52 smgery smgery NNP cord-015021-pol2qm74 8611 53 . . . cord-015021-pol2qm74 8612 1 This this DT cord-015021-pol2qm74 8612 2 second second JJ cord-015021-pol2qm74 8612 3 release release NN cord-015021-pol2qm74 8612 4 was be VBD cord-015021-pol2qm74 8612 5 concomitant concomitant JJ cord-015021-pol2qm74 8612 6 with with IN cord-015021-pol2qm74 8612 7 abnormal abnormal JJ cord-015021-pol2qm74 8612 8 levels level NNS cord-015021-pol2qm74 8612 9 of of IN cord-015021-pol2qm74 8612 10 llpase llpase NN cord-015021-pol2qm74 8612 11 . . . cord-015021-pol2qm74 8613 1 These these DT cord-015021-pol2qm74 8613 2 biochemical biochemical JJ cord-015021-pol2qm74 8613 3 observations observation NNS cord-015021-pol2qm74 8613 4 were be VBD cord-015021-pol2qm74 8613 5 accompanied accompany VBN cord-015021-pol2qm74 8613 6 by by IN cord-015021-pol2qm74 8613 7 radiological radiological JJ cord-015021-pol2qm74 8613 8 and and CC cord-015021-pol2qm74 8613 9 clinical clinical JJ cord-015021-pol2qm74 8613 10 signs sign NNS cord-015021-pol2qm74 8613 11 of of IN cord-015021-pol2qm74 8613 12 pancreatic pancreatic JJ cord-015021-pol2qm74 8613 13 injury injury NN cord-015021-pol2qm74 8613 14 in in IN cord-015021-pol2qm74 8613 15 about about RB cord-015021-pol2qm74 8613 16 2 2 CD cord-015021-pol2qm74 8613 17 % % NN cord-015021-pol2qm74 8613 18 of of IN cord-015021-pol2qm74 8613 19 our -PRON- PRP$ cord-015021-pol2qm74 8613 20 patients patient NNS cord-015021-pol2qm74 8613 21 : : : cord-015021-pol2qm74 8613 22 pancrealic pancrealic NNP cord-015021-pol2qm74 8613 23 abnormalities abnormality NNS cord-015021-pol2qm74 8613 24 were be VBD cord-015021-pol2qm74 8613 25 revealed reveal VBN cord-015021-pol2qm74 8613 26 by by IN cord-015021-pol2qm74 8613 27 scan scan NN cord-015021-pol2qm74 8613 28 in in IN cord-015021-pol2qm74 8613 29 7 7 CD cord-015021-pol2qm74 8613 30 patients patient NNS cord-015021-pol2qm74 8613 31 and and CC cord-015021-pol2qm74 8613 32 acute acute JJ cord-015021-pol2qm74 8613 33 pancreatitis pancreatitis NN cord-015021-pol2qm74 8613 34 in in IN cord-015021-pol2qm74 8613 35 I -PRON- PRP cord-015021-pol2qm74 8613 36 patient patient JJ cord-015021-pol2qm74 8613 37 . . . cord-015021-pol2qm74 8614 1 More more RBR cord-015021-pol2qm74 8614 2 pronounced pronounce VBN cord-015021-pol2qm74 8614 3 pancreatic pancreatic NN cord-015021-pol2qm74 8614 4 suffering suffering NN cord-015021-pol2qm74 8614 5 was be VBD cord-015021-pol2qm74 8614 6 observed observe VBN cord-015021-pol2qm74 8614 7 in in IN cord-015021-pol2qm74 8614 8 patients patient NNS cord-015021-pol2qm74 8614 9 undergoing undergo VBG cord-015021-pol2qm74 8614 10 valve valve NN cord-015021-pol2qm74 8614 11 replacement replacement NN cord-015021-pol2qm74 8614 12 than than IN cord-015021-pol2qm74 8614 13 in in IN cord-015021-pol2qm74 8614 14 patients patient NNS cord-015021-pol2qm74 8614 15 undergoing undergo VBG cord-015021-pol2qm74 8614 16 coronam coronam NN cord-015021-pol2qm74 8614 17 - - HYPH cord-015021-pol2qm74 8614 18 anrtic anrtic JJ cord-015021-pol2qm74 8614 19 bypass bypass NN cord-015021-pol2qm74 8614 20 grafm~ grafm~ NN cord-015021-pol2qm74 8615 1 g. g. NNP cord-015021-pol2qm74 8616 1 Analysis analysis NN cord-015021-pol2qm74 8616 2 of of IN cord-015021-pol2qm74 8616 3 trypsin trypsin NN cord-015021-pol2qm74 8616 4 and and CC cord-015021-pol2qm74 8616 5 pare're pare're NNP cord-015021-pol2qm74 8617 1 , , , cord-015021-pol2qm74 8617 2 tic tic NNP cord-015021-pol2qm74 8617 3 1so 1so NNS cord-015021-pol2qm74 8617 4 - - HYPH cord-015021-pol2qm74 8617 5 amylase amylase NN cord-015021-pol2qm74 8617 6 are be VBP cord-015021-pol2qm74 8617 7 sw.cific sw.cific NNP cord-015021-pol2qm74 8617 8 of of IN cord-015021-pol2qm74 8617 9 pancreatic pancreatic JJ cord-015021-pol2qm74 8617 10 cellular cellular JJ cord-015021-pol2qm74 8617 11 injury injury NN cord-015021-pol2qm74 8617 12 and and CC cord-015021-pol2qm74 8617 13 their -PRON- PRP$ cord-015021-pol2qm74 8617 14 simultaneous simultaneous JJ cord-015021-pol2qm74 8617 15 ir ir NNP cord-015021-pol2qm74 8617 16 ~ ~ NNP cord-015021-pol2qm74 8617 17 rease rease NNP cord-015021-pol2qm74 8617 18 in in IN cord-015021-pol2qm74 8617 19 plasma plasma NN cord-015021-pol2qm74 8617 20 alter alter VB cord-015021-pol2qm74 8617 21 CPB CPB NNP cord-015021-pol2qm74 8617 22 in in IN cord-015021-pol2qm74 8617 23 our -PRON- PRP$ cord-015021-pol2qm74 8617 24 padents padent NNS cord-015021-pol2qm74 8617 25 confirms confirm VBZ cord-015021-pol2qm74 8617 26 the the DT cord-015021-pol2qm74 8617 27 presence presence NN cord-015021-pol2qm74 8617 28 of of IN cord-015021-pol2qm74 8617 29 an an DT cord-015021-pol2qm74 8617 30 exocrine exocrine JJ cord-015021-pol2qm74 8617 31 pancreatic pancreatic NN cord-015021-pol2qm74 8617 32 injury injury NN cord-015021-pol2qm74 8617 33 . . . cord-015021-pol2qm74 8618 1 The the DT cord-015021-pol2qm74 8618 2 presence presence NN cord-015021-pol2qm74 8618 3 of of IN cord-015021-pol2qm74 8618 4 a a DT cord-015021-pol2qm74 8618 5 simultaneous simultaneous JJ cord-015021-pol2qm74 8618 6 peak peak NN cord-015021-pol2qm74 8618 7 of of IN cord-015021-pol2qm74 8618 8 lipase lipase NN cord-015021-pol2qm74 8618 9 mcaezse~ mcaezse~ NNP cord-015021-pol2qm74 8618 10 the the DT cord-015021-pol2qm74 8618 11 specificity specificity NN cord-015021-pol2qm74 8618 12 of of IN cord-015021-pol2qm74 8618 13 overt overt JJ cord-015021-pol2qm74 8618 14 pancreatic pancreatic NN cord-015021-pol2qm74 8618 15 injtu injtu NNP cord-015021-pol2qm74 8618 16 7 7 CD cord-015021-pol2qm74 8618 17 diagnosis diagnosis NN cord-015021-pol2qm74 8618 18 . . . cord-015021-pol2qm74 8619 1 The the DT cord-015021-pol2qm74 8619 2 precise precise JJ cord-015021-pol2qm74 8619 3 cause cause NN cord-015021-pol2qm74 8619 4 of of IN cord-015021-pol2qm74 8619 5 th th XX cord-015021-pol2qm74 8619 6 / / SYM cord-015021-pol2qm74 8619 7 s s POS cord-015021-pol2qm74 8619 8 injury injury NN cord-015021-pol2qm74 8619 9 could could MD cord-015021-pol2qm74 8619 10 he -PRON- PRP cord-015021-pol2qm74 8619 11 related relate VBN cord-015021-pol2qm74 8619 12 to to IN cord-015021-pol2qm74 8619 13 hypoperfnsion hypoperfnsion NN cord-015021-pol2qm74 8619 14 leading lead VBG cord-015021-pol2qm74 8619 15 to to IN cord-015021-pol2qm74 8619 16 ischemic ischemic JJ cord-015021-pol2qm74 8619 17 injury injury NN cord-015021-pol2qm74 8619 18 of of IN cord-015021-pol2qm74 8619 19 foe foe NNP cord-015021-pol2qm74 8619 20 splancbnic splancbnic NNP cord-015021-pol2qm74 8619 21 area area NN cord-015021-pol2qm74 8619 22 , , , cord-015021-pol2qm74 8619 23 pancreas pancrea NNS cord-015021-pol2qm74 8619 24 being be VBG cord-015021-pol2qm74 8619 25 largely largely RB cord-015021-pol2qm74 8619 26 sensible sensible JJ cord-015021-pol2qm74 8619 27 to to IN cord-015021-pol2qm74 8619 28 hypoperfnsion hypoperfnsion NN cord-015021-pol2qm74 8619 29 ( ( -LRB- cord-015021-pol2qm74 8619 30 7 7 CD cord-015021-pol2qm74 8619 31 ) ) -RRB- cord-015021-pol2qm74 8619 32 . . . cord-015021-pol2qm74 8620 1 This this DT cord-015021-pol2qm74 8620 2 hypoperfosion hypoperfosion NN cord-015021-pol2qm74 8620 3 could could MD cord-015021-pol2qm74 8620 4 he -PRON- PRP cord-015021-pol2qm74 8620 5 responsible responsible JJ cord-015021-pol2qm74 8620 6 for for IN cord-015021-pol2qm74 8620 7 the the DT cord-015021-pol2qm74 8620 8 ftmt ftmt NNP cord-015021-pol2qm74 8620 9 release release NN cord-015021-pol2qm74 8620 10 of of IN cord-015021-pol2qm74 8620 11 pancrealac pancrealac NNP cord-015021-pol2qm74 8620 12 enzymes enzyme NNS cord-015021-pol2qm74 8620 13 observed observe VBN cord-015021-pol2qm74 8620 14 in in IN cord-015021-pol2qm74 8620 15 our -PRON- PRP$ cord-015021-pol2qm74 8620 16 patients patient NNS cord-015021-pol2qm74 8620 17 and and CC cord-015021-pol2qm74 8620 18 would would MD cord-015021-pol2qm74 8620 19 contribute contribute VB cord-015021-pol2qm74 8620 20 to to IN cord-015021-pol2qm74 8620 21 the the DT cord-015021-pol2qm74 8620 22 deterioration deterioration NN cord-015021-pol2qm74 8620 23 of of IN cord-015021-pol2qm74 8620 24 other other JJ cord-015021-pol2qm74 8620 25 organs organ NNS cord-015021-pol2qm74 8620 26 leading lead VBG cord-015021-pol2qm74 8620 27 to to IN cord-015021-pol2qm74 8620 28 an an DT cord-015021-pol2qm74 8620 29 inflammatory inflammatory JJ cord-015021-pol2qm74 8620 30 reaction reaction NN cord-015021-pol2qm74 8620 31 developing develop VBG cord-015021-pol2qm74 8620 32 in in IN cord-015021-pol2qm74 8620 33 the the DT cord-015021-pol2qm74 8620 34 following follow VBG cord-015021-pol2qm74 8620 35 days day NNS cord-015021-pol2qm74 8620 36 and and CC cord-015021-pol2qm74 8620 37 responsible responsible JJ cord-015021-pol2qm74 8620 38 for for IN cord-015021-pol2qm74 8620 39 the the DT cord-015021-pol2qm74 8620 40 second second JJ cord-015021-pol2qm74 8620 41 release release NN cord-015021-pol2qm74 8620 42 of of IN cord-015021-pol2qm74 8620 43 pancreatic pancreatic JJ cord-015021-pol2qm74 8620 44 enzymes enzyme NNS cord-015021-pol2qm74 8620 45 observed observe VBN cord-015021-pol2qm74 8620 46 in in IN cord-015021-pol2qm74 8620 47 our -PRON- PRP$ cord-015021-pol2qm74 8620 48 patients patient NNS cord-015021-pol2qm74 8620 49 . . . cord-015021-pol2qm74 8621 1 Patients patient NNS cord-015021-pol2qm74 8621 2 with with IN cord-015021-pol2qm74 8621 3 necrotizing necrotize VBG cord-015021-pol2qm74 8621 4 pancreatitis pancreatitis NN cord-015021-pol2qm74 8621 5 show show VBP cord-015021-pol2qm74 8621 6 a a DT cord-015021-pol2qm74 8621 7 heigh heigh JJ cord-015021-pol2qm74 8621 8 rate rate NN cord-015021-pol2qm74 8621 9 of of IN cord-015021-pol2qm74 8621 10 pulmonary pulmonary JJ cord-015021-pol2qm74 8621 11 , , , cord-015021-pol2qm74 8621 12 renal renal JJ cord-015021-pol2qm74 8621 13 and and CC cord-015021-pol2qm74 8621 14 septic septic JJ cord-015021-pol2qm74 8621 15 complications complication NNS cord-015021-pol2qm74 8621 16 , , , cord-015021-pol2qm74 8621 17 whereas whereas IN cord-015021-pol2qm74 8621 18 the the DT cord-015021-pol2qm74 8621 19 course course NN cord-015021-pol2qm74 8621 20 in in IN cord-015021-pol2qm74 8621 21 acute acute JJ cord-015021-pol2qm74 8621 22 interstitial interstitial JJ cord-015021-pol2qm74 8621 23 pancreatitis pancreatitis NN cord-015021-pol2qm74 8621 24 is be VBZ cord-015021-pol2qm74 8621 25 generally generally RB cord-015021-pol2qm74 8621 26 very very RB cord-015021-pol2qm74 8621 27 mild mild JJ cord-015021-pol2qm74 8621 28 . . . cord-015021-pol2qm74 8622 1 We -PRON- PRP cord-015021-pol2qm74 8622 2 have have VBP cord-015021-pol2qm74 8622 3 prospectively prospectively RB cord-015021-pol2qm74 8622 4 analysed analyse VBN cord-015021-pol2qm74 8622 5 the the DT cord-015021-pol2qm74 8622 6 value value NN cord-015021-pol2qm74 8622 7 of of IN cord-015021-pol2qm74 8622 8 Endotoxin endotoxin NN cord-015021-pol2qm74 8622 9 , , , cord-015021-pol2qm74 8622 10 Interleukin-6(IL-6 interleukin-6(il-6 NN cord-015021-pol2qm74 8622 11 ) ) -RRB- cord-015021-pol2qm74 8622 12 and and CC cord-015021-pol2qm74 8622 13 Transferrin Transferrin NNP cord-015021-pol2qm74 8622 14 in in IN cord-015021-pol2qm74 8622 15 compare compare NN cord-015021-pol2qm74 8622 16 with with IN cord-015021-pol2qm74 8622 17 c c NN cord-015021-pol2qm74 8622 18 - - HYPH cord-015021-pol2qm74 8622 19 reactive reactive JJ cord-015021-pol2qm74 8622 20 protein(CRP protein(CRP NNP cord-015021-pol2qm74 8622 21 ) ) -RRB- cord-015021-pol2qm74 8622 22 for for IN cord-015021-pol2qm74 8622 23 the the DT cord-015021-pol2qm74 8622 24 early early JJ cord-015021-pol2qm74 8622 25 assessment assessment NN cord-015021-pol2qm74 8622 26 of of IN cord-015021-pol2qm74 8622 27 the the DT cord-015021-pol2qm74 8622 28 severity severity NN cord-015021-pol2qm74 8622 29 of of IN cord-015021-pol2qm74 8622 30 acute acute JJ cord-015021-pol2qm74 8622 31 pancreatitis pancreatitis NN cord-015021-pol2qm74 8622 32 . . . cord-015021-pol2qm74 8623 1 Patients patient NNS cord-015021-pol2qm74 8623 2 aud aud NN cord-015021-pol2qm74 8623 3 methods method NNS cord-015021-pol2qm74 8623 4 : : : cord-015021-pol2qm74 8624 1 The the DT cord-015021-pol2qm74 8624 2 values value NNS cord-015021-pol2qm74 8624 3 of of IN cord-015021-pol2qm74 8624 4 Endotoxin(measured endotoxin(measure VBN cord-015021-pol2qm74 8624 5 by by IN cord-015021-pol2qm74 8624 6 limulus limulus NN cord-015021-pol2qm74 8624 7 - - HYPH cord-015021-pol2qm74 8624 8 lysate lysate NN cord-015021-pol2qm74 8624 9 - - HYPH cord-015021-pol2qm74 8624 10 test test NN cord-015021-pol2qm74 8624 11 ) ) -RRB- cord-015021-pol2qm74 8624 12 , , , cord-015021-pol2qm74 8624 13 II-6(ELISA II-6(ELISA NNP cord-015021-pol2qm74 8624 14 ) ) -RRB- cord-015021-pol2qm74 8624 15 , , , cord-015021-pol2qm74 8624 16 transferrin transferrin NN cord-015021-pol2qm74 8624 17 and and CC cord-015021-pol2qm74 8624 18 CRP CRP NNP cord-015021-pol2qm74 8624 19 ( ( -LRB- cord-015021-pol2qm74 8624 20 nephelometry nephelometry NNP cord-015021-pol2qm74 8624 21 ) ) -RRB- cord-015021-pol2qm74 8624 22 were be VBD cord-015021-pol2qm74 8624 23 analysed analyse VBN cord-015021-pol2qm74 8624 24 daily daily RB cord-015021-pol2qm74 8624 25 along along IN cord-015021-pol2qm74 8624 26 the the DT cord-015021-pol2qm74 8624 27 first first JJ cord-015021-pol2qm74 8624 28 i0 i0 NN cord-015021-pol2qm74 8624 29 days day NNS cord-015021-pol2qm74 8624 30 of of IN cord-015021-pol2qm74 8624 31 hospitalisation hospitalisation NN cord-015021-pol2qm74 8624 32 by by IN cord-015021-pol2qm74 8624 33 28 28 CD cord-015021-pol2qm74 8624 34 patients patient NNS cord-015021-pol2qm74 8624 35 with with IN cord-015021-pol2qm74 8624 36 acute acute JJ cord-015021-pol2qm74 8624 37 pancreatitis pancreatitis NN cord-015021-pol2qm74 8624 38 admitted admit VBN cord-015021-pol2qm74 8624 39 to to IN cord-015021-pol2qm74 8624 40 our -PRON- PRP$ cord-015021-pol2qm74 8624 41 Hospital Hospital NNP cord-015021-pol2qm74 8624 42 from from IN cord-015021-pol2qm74 8624 43 4/1991 4/1991 CD cord-015021-pol2qm74 8624 44 to to IN cord-015021-pol2qm74 8624 45 4/1993 4/1993 CD cord-015021-pol2qm74 8624 46 . . . cord-015021-pol2qm74 8625 1 It -PRON- PRP cord-015021-pol2qm74 8625 2 was be VBD cord-015021-pol2qm74 8625 3 judged judge VBN cord-015021-pol2qm74 8625 4 whether whether IN cord-015021-pol2qm74 8625 5 the the DT cord-015021-pol2qm74 8625 6 patients patient NNS cord-015021-pol2qm74 8625 7 have have VBP cord-015021-pol2qm74 8625 8 either either DT cord-015021-pol2qm74 8625 9 interstitial interstitial JJ cord-015021-pol2qm74 8625 10 ( ( -LRB- cord-015021-pol2qm74 8625 11 AIP aip NN cord-015021-pol2qm74 8625 12 ) ) -RRB- cord-015021-pol2qm74 8625 13 ( ( -LRB- cord-015021-pol2qm74 8625 14 n=9 n=9 NN cord-015021-pol2qm74 8625 15 ) ) -RRB- cord-015021-pol2qm74 8625 16 or or CC cord-015021-pol2qm74 8625 17 necrotizing necrotize VBG cord-015021-pol2qm74 8625 18 ( ( -LRB- cord-015021-pol2qm74 8625 19 ANP ANP NNP cord-015021-pol2qm74 8625 20 ) ) -RRB- cord-015021-pol2qm74 8626 1 ( ( -LRB- cord-015021-pol2qm74 8626 2 n n NN cord-015021-pol2qm74 8626 3 = = SYM cord-015021-pol2qm74 8626 4 lg lg NNP cord-015021-pol2qm74 8626 5 ) ) -RRB- cord-015021-pol2qm74 8626 6 pancreatitis pancreatitis NN cord-015021-pol2qm74 8626 7 . . . cord-015021-pol2qm74 8627 1 5 5 CD cord-015021-pol2qm74 8627 2 patients patient NNS cord-015021-pol2qm74 8627 3 with with IN cord-015021-pol2qm74 8627 4 ANP ANP NNP cord-015021-pol2qm74 8627 5 have have VBP cord-015021-pol2qm74 8627 6 died die VBN cord-015021-pol2qm74 8627 7 during during IN cord-015021-pol2qm74 8627 8 the the DT cord-015021-pol2qm74 8627 9 course course NN cord-015021-pol2qm74 8627 10 of of IN cord-015021-pol2qm74 8627 11 pancreatitis pancreatitis NN cord-015021-pol2qm74 8627 12 ( ( -LRB- cord-015021-pol2qm74 8627 13 Mortality=17.5 Mortality=17.5 NNP cord-015021-pol2qm74 8627 14 % % NN cord-015021-pol2qm74 8627 15 ) ) -RRB- cord-015021-pol2qm74 8627 16 . . . cord-015021-pol2qm74 8628 1 Results result NNS cord-015021-pol2qm74 8628 2 : : : cord-015021-pol2qm74 8629 1 1-Severity 1-severity CD cord-015021-pol2qm74 8629 2 o~ o~ CD cord-015021-pol2qm74 8629 3 Pancreatitis pancreatitis NN cord-015021-pol2qm74 8629 4 : : : cord-015021-pol2qm74 8630 1 Signifcant signifcant JJ cord-015021-pol2qm74 8630 2 differences difference NNS cord-015021-pol2qm74 8630 3 ( ( -LRB- cord-015021-pol2qm74 8630 4 P p NN cord-015021-pol2qm74 8630 5 < < XX cord-015021-pol2qm74 8630 6 O.05 o.05 XX cord-015021-pol2qm74 8630 7 , , , cord-015021-pol2qm74 8630 8 Mann Mann NNP cord-015021-pol2qm74 8630 9 - - HYPH cord-015021-pol2qm74 8630 10 Whitney Whitney NNP cord-015021-pol2qm74 8630 11 test test NN cord-015021-pol2qm74 8630 12 ) ) -RRB- cord-015021-pol2qm74 8630 13 could could MD cord-015021-pol2qm74 8630 14 be be VB cord-015021-pol2qm74 8630 15 calculated calculate VBN cord-015021-pol2qm74 8630 16 between between IN cord-015021-pol2qm74 8630 17 AIP AIP NNP cord-015021-pol2qm74 8630 18 and and CC cord-015021-pol2qm74 8630 19 ANP ANP NNP cord-015021-pol2qm74 8630 20 for for IN cord-015021-pol2qm74 8630 21 endotoxin endotoxin NN cord-015021-pol2qm74 8630 22 , , , cord-015021-pol2qm74 8630 23 IL-6 IL-6 NNP cord-015021-pol2qm74 8630 24 , , , cord-015021-pol2qm74 8630 25 transferrin transferrin NN cord-015021-pol2qm74 8630 26 and and CC cord-015021-pol2qm74 8630 27 CRP crp NN cord-015021-pol2qm74 8630 28 during during IN cord-015021-pol2qm74 8630 29 the the DT cord-015021-pol2qm74 8630 30 I0 i0 NN cord-015021-pol2qm74 8630 31 days day NNS cord-015021-pol2qm74 8630 32 of of IN cord-015021-pol2qm74 8630 33 monitoring monitoring NN cord-015021-pol2qm74 8630 34 . . . cord-015021-pol2qm74 8631 1 2-Mortality 2-mortality CD cord-015021-pol2qm74 8631 2 : : : cord-015021-pol2qm74 8632 1 Except except IN cord-015021-pol2qm74 8632 2 of of IN cord-015021-pol2qm74 8632 3 IL-6 IL-6 NNP cord-015021-pol2qm74 8632 4 on on IN cord-015021-pol2qm74 8632 5 days day NNS cord-015021-pol2qm74 8632 6 2 2 CD cord-015021-pol2qm74 8632 7 , , , cord-015021-pol2qm74 8632 8 3 3 CD cord-015021-pol2qm74 8632 9 , , , cord-015021-pol2qm74 8632 10 4 4 CD cord-015021-pol2qm74 8632 11 and and CC cord-015021-pol2qm74 8632 12 5 5 CD cord-015021-pol2qm74 8632 13 after after IN cord-015021-pol2qm74 8632 14 ad ad NN cord-015021-pol2qm74 8632 15 - - HYPH cord-015021-pol2qm74 8632 16 mission mission NN cord-015021-pol2qm74 8632 17 there there EX cord-015021-pol2qm74 8632 18 were be VBD cord-015021-pol2qm74 8632 19 no no DT cord-015021-pol2qm74 8632 20 significant significant JJ cord-015021-pol2qm74 8632 21 differences difference NNS cord-015021-pol2qm74 8632 22 between between IN cord-015021-pol2qm74 8632 23 the the DT cord-015021-pol2qm74 8632 24 values value NNS cord-015021-pol2qm74 8632 25 of of IN cord-015021-pol2qm74 8632 26 analysed analyse VBN cord-015021-pol2qm74 8632 27 parameters parameter NNS cord-015021-pol2qm74 8632 28 in in IN cord-015021-pol2qm74 8632 29 patients patient NNS cord-015021-pol2qm74 8632 30 who who WP cord-015021-pol2qm74 8632 31 survived survive VBD cord-015021-pol2qm74 8632 32 and and CC cord-015021-pol2qm74 8632 33 those those DT cord-015021-pol2qm74 8632 34 values value NNS cord-015021-pol2qm74 8632 35 in in IN cord-015021-pol2qm74 8632 36 patients patient NNS cord-015021-pol2qm74 8632 37 who who WP cord-015021-pol2qm74 8632 38 died die VBD cord-015021-pol2qm74 8632 39 . . . cord-015021-pol2qm74 8633 1 3-Organ 3-organ CD cord-015021-pol2qm74 8633 2 failure failure NN cord-015021-pol2qm74 8633 3 : : : cord-015021-pol2qm74 8634 1 The the DT cord-015021-pol2qm74 8634 2 patients patient NNS cord-015021-pol2qm74 8634 3 with with IN cord-015021-pol2qm74 8634 4 pulmonary pulmonary JJ cord-015021-pol2qm74 8634 5 , , , cord-015021-pol2qm74 8634 6 renal renal JJ cord-015021-pol2qm74 8634 7 or or CC cord-015021-pol2qm74 8634 8 multiorgan multiorgan NN cord-015021-pol2qm74 8634 9 failure failure NN cord-015021-pol2qm74 8634 10 have have VBP cord-015021-pol2qm74 8634 11 significantly significantly RB cord-015021-pol2qm74 8634 12 heigher heigh JJR cord-015021-pol2qm74 8634 13 values value NNS cord-015021-pol2qm74 8634 14 of of IN cord-015021-pol2qm74 8634 15 endotoxin endotoxin NN cord-015021-pol2qm74 8634 16 , , , cord-015021-pol2qm74 8634 17 IL-6 IL-6 NNP cord-015021-pol2qm74 8634 18 and and CC cord-015021-pol2qm74 8634 19 CRP CRP NNP cord-015021-pol2qm74 8634 20 along along IN cord-015021-pol2qm74 8634 21 the the DT cord-015021-pol2qm74 8634 22 I0 i0 NN cord-015021-pol2qm74 8634 23 days day NNS cord-015021-pol2qm74 8634 24 of of IN cord-015021-pol2qm74 8634 25 monitoring monitoring NN cord-015021-pol2qm74 8634 26 in in IN cord-015021-pol2qm74 8634 27 compare compare NN cord-015021-pol2qm74 8634 28 with with IN cord-015021-pol2qm74 8634 29 those those DT cord-015021-pol2qm74 8634 30 patients patient NNS cord-015021-pol2qm74 8634 31 without without IN cord-015021-pol2qm74 8634 32 an an DT cord-015021-pol2qm74 8634 33 organ organ NN cord-015021-pol2qm74 8634 34 failure failure NN cord-015021-pol2qm74 8634 35 . . . cord-015021-pol2qm74 8635 1 Conclusions conclusion NNS cord-015021-pol2qm74 8635 2 : : : cord-015021-pol2qm74 8636 1 Endotoxin Endotoxin NNP cord-015021-pol2qm74 8636 2 , , , cord-015021-pol2qm74 8636 3 IL-6 IL-6 NNP cord-015021-pol2qm74 8636 4 and and CC cord-015021-pol2qm74 8636 5 Transferrin Transferrin NNP cord-015021-pol2qm74 8636 6 , , , cord-015021-pol2qm74 8636 7 an an DT cord-015021-pol2qm74 8636 8 important important JJ cord-015021-pol2qm74 8636 9 endotoxin endotoxin NN cord-015021-pol2qm74 8636 10 carrier carrier NN cord-015021-pol2qm74 8636 11 , , , cord-015021-pol2qm74 8636 12 are be VBP cord-015021-pol2qm74 8636 13 promising promising JJ cord-015021-pol2qm74 8636 14 parameters parameter NNS cord-015021-pol2qm74 8636 15 to to TO cord-015021-pol2qm74 8636 16 differentiate differentiate VB cord-015021-pol2qm74 8636 17 between between IN cord-015021-pol2qm74 8636 18 the the DT cord-015021-pol2qm74 8636 19 severe severe JJ cord-015021-pol2qm74 8636 20 and and CC cord-015021-pol2qm74 8636 21 mild mild JJ cord-015021-pol2qm74 8636 22 form form NN cord-015021-pol2qm74 8636 23 of of IN cord-015021-pol2qm74 8636 24 pancreatitis pancreatitis NN cord-015021-pol2qm74 8636 25 comparable comparable JJ cord-015021-pol2qm74 8636 26 with with IN cord-015021-pol2qm74 8636 27 CRP CRP NNP cord-015021-pol2qm74 8636 28 . . . cord-015021-pol2qm74 8637 1 This this DT cord-015021-pol2qm74 8637 2 parameters parameter NNS cord-015021-pol2qm74 8637 3 may may MD cord-015021-pol2qm74 8637 4 be be VB cord-015021-pol2qm74 8637 5 helpfull helpfull JJ cord-015021-pol2qm74 8637 6 in in IN cord-015021-pol2qm74 8637 7 the the DT cord-015021-pol2qm74 8637 8 early early JJ cord-015021-pol2qm74 8637 9 clinical clinical JJ cord-015021-pol2qm74 8637 10 assessment assessment NN cord-015021-pol2qm74 8637 11 of of IN cord-015021-pol2qm74 8637 12 patients patient NNS cord-015021-pol2qm74 8637 13 with with IN cord-015021-pol2qm74 8637 14 acute acute JJ cord-015021-pol2qm74 8637 15 panereatitis panereatitis NNP cord-015021-pol2qm74 8637 16 . . . cord-015021-pol2qm74 8638 1 The the DT cord-015021-pol2qm74 8638 2 determination determination NN cord-015021-pol2qm74 8638 3 of of IN cord-015021-pol2qm74 8638 4 cytokines cytokine NNS cord-015021-pol2qm74 8638 5 may may MD cord-015021-pol2qm74 8638 6 elucidate elucidate VB cord-015021-pol2qm74 8638 7 the the DT cord-015021-pol2qm74 8638 8 pathophysiologic pathophysiologic NN cord-015021-pol2qm74 8638 9 mechanisms mechanism NNS cord-015021-pol2qm74 8638 10 that that WDT cord-015021-pol2qm74 8638 11 produce produce VBP cord-015021-pol2qm74 8638 12 early early JJ cord-015021-pol2qm74 8638 13 systemic systemic JJ cord-015021-pol2qm74 8638 14 complications complication NNS cord-015021-pol2qm74 8638 15 in in IN cord-015021-pol2qm74 8638 16 acute acute JJ cord-015021-pol2qm74 8638 17 interstitial interstitial NN cord-015021-pol2qm74 8638 18 ( ( -LRB- cord-015021-pol2qm74 8638 19 i i NN cord-015021-pol2qm74 8638 20 ) ) -RRB- cord-015021-pol2qm74 8638 21 or or CC cord-015021-pol2qm74 8638 22 necrotizing necrotize VBG cord-015021-pol2qm74 8638 23 ( ( -LRB- cord-015021-pol2qm74 8638 24 n n LS cord-015021-pol2qm74 8638 25 ) ) -RRB- cord-015021-pol2qm74 8638 26 pancreatitis pancreatitis NNP cord-015021-pol2qm74 8638 27 ( ( -LRB- cord-015021-pol2qm74 8638 28 AP AP NNP cord-015021-pol2qm74 8638 29 ) ) -RRB- cord-015021-pol2qm74 8638 30 . . . cord-015021-pol2qm74 8639 1 The the DT cord-015021-pol2qm74 8639 2 appearence appearence NN cord-015021-pol2qm74 8639 3 of of IN cord-015021-pol2qm74 8639 4 respiratory respiratory JJ cord-015021-pol2qm74 8639 5 insufficiency insufficiency NN cord-015021-pol2qm74 8639 6 ( ( -LRB- cord-015021-pol2qm74 8639 7 RI RI NNP cord-015021-pol2qm74 8639 8 ) ) -RRB- cord-015021-pol2qm74 8639 9 is be VBZ cord-015021-pol2qm74 8639 10 used use VBN cord-015021-pol2qm74 8639 11 to to TO cord-015021-pol2qm74 8639 12 appraise appraise VB cord-015021-pol2qm74 8639 13 the the DT cord-015021-pol2qm74 8639 14 early early JJ cord-015021-pol2qm74 8639 15 systemic systemic JJ cord-015021-pol2qm74 8639 16 complications complication NNS cord-015021-pol2qm74 8639 17 and and CC cord-015021-pol2qm74 8639 18 is be VBZ cord-015021-pol2qm74 8639 19 compared compare VBN cord-015021-pol2qm74 8639 20 to to IN cord-015021-pol2qm74 8639 21 the the DT cord-015021-pol2qm74 8639 22 results result NNS cord-015021-pol2qm74 8639 23 of of IN cord-015021-pol2qm74 8639 24 cytokine cytokine JJ cord-015021-pol2qm74 8639 25 blood blood NN cord-015021-pol2qm74 8639 26 levels level NNS cord-015021-pol2qm74 8639 27 . . . cord-015021-pol2qm74 8640 1 In in IN cord-015021-pol2qm74 8640 2 a a DT cord-015021-pol2qm74 8640 3 prospective prospective JJ cord-015021-pol2qm74 8640 4 clinical clinical JJ cord-015021-pol2qm74 8640 5 trial trial NN cord-015021-pol2qm74 8640 6 from from IN cord-015021-pol2qm74 8640 7 10/92 10/92 CD cord-015021-pol2qm74 8640 8 -8/93 -8/93 NNS cord-015021-pol2qm74 8640 9 , , , cord-015021-pol2qm74 8640 10 23 23 CD cord-015021-pol2qm74 8640 11 patients patient NNS cord-015021-pol2qm74 8640 12 with with IN cord-015021-pol2qm74 8640 13 AP AP NNP cord-015021-pol2qm74 8640 14 were be VBD cord-015021-pol2qm74 8640 15 recruited recruit VBN cord-015021-pol2qm74 8640 16 and and CC cord-015021-pol2qm74 8640 17 blood blood NN cord-015021-pol2qm74 8640 18 samples sample NNS cord-015021-pol2qm74 8640 19 taken take VBN cord-015021-pol2qm74 8640 20 for for IN cord-015021-pol2qm74 8640 21 cytokine cytokine JJ cord-015021-pol2qm74 8640 22 determination determination NN cord-015021-pol2qm74 8640 23 with with IN cord-015021-pol2qm74 8640 24 commercial commercial JJ cord-015021-pol2qm74 8640 25 ELISA ELISA NNP cord-015021-pol2qm74 8640 26 - - HYPH cord-015021-pol2qm74 8640 27 kits kit NNS cord-015021-pol2qm74 8640 28 . . . cord-015021-pol2qm74 8641 1 The the DT cord-015021-pol2qm74 8641 2 differentiation differentiation NN cord-015021-pol2qm74 8641 3 between between IN cord-015021-pol2qm74 8641 4 i i PRP cord-015021-pol2qm74 8641 5 ( ( -LRB- cord-015021-pol2qm74 8641 6 n=12 n=12 NNP cord-015021-pol2qm74 8641 7 ) ) -RRB- cord-015021-pol2qm74 8641 8 and and CC cord-015021-pol2qm74 8641 9 n n NNP cord-015021-pol2qm74 8642 1 ( ( -LRB- cord-015021-pol2qm74 8642 2 n n NN cord-015021-pol2qm74 8642 3 = = SYM cord-015021-pol2qm74 8642 4 l l NN cord-015021-pol2qm74 8642 5 1 1 CD cord-015021-pol2qm74 8642 6 ) ) -RRB- cord-015021-pol2qm74 8642 7 AP AP NNP cord-015021-pol2qm74 8642 8 was be VBD cord-015021-pol2qm74 8642 9 made make VBN cord-015021-pol2qm74 8642 10 through through IN cord-015021-pol2qm74 8642 11 Ct Ct NNP cord-015021-pol2qm74 8642 12 - - NN cord-015021-pol2qm74 8642 13 scan scan NN cord-015021-pol2qm74 8642 14 in in IN cord-015021-pol2qm74 8642 15 all all DT cord-015021-pol2qm74 8642 16 and and CC cord-015021-pol2qm74 8642 17 laparotomy laparotomy NN cord-015021-pol2qm74 8642 18 for for IN cord-015021-pol2qm74 8642 19 drainage drainage NN cord-015021-pol2qm74 8642 20 and and CC cord-015021-pol2qm74 8642 21 necrosectomy necrosectomy NN cord-015021-pol2qm74 8642 22 in in IN cord-015021-pol2qm74 8642 23 13 13 CD cord-015021-pol2qm74 8642 24 patients patient NNS cord-015021-pol2qm74 8642 25 . . . cord-015021-pol2qm74 8643 1 The the DT cord-015021-pol2qm74 8643 2 etiology etiology NN cord-015021-pol2qm74 8643 3 of of IN cord-015021-pol2qm74 8643 4 AP AP NNP cord-015021-pol2qm74 8643 5 was be VBD cord-015021-pol2qm74 8643 6 gallstones gallstone NNS cord-015021-pol2qm74 8643 7 in in IN cord-015021-pol2qm74 8643 8 9 9 CD cord-015021-pol2qm74 8643 9 , , , cord-015021-pol2qm74 8643 10 alcohol alcohol NN cord-015021-pol2qm74 8643 11 abuse abuse NN cord-015021-pol2qm74 8643 12 in in IN cord-015021-pol2qm74 8643 13 7 7 CD cord-015021-pol2qm74 8643 14 , , , cord-015021-pol2qm74 8643 15 hyperlipidemia hyperlipidemia NN cord-015021-pol2qm74 8643 16 in in IN cord-015021-pol2qm74 8643 17 2 2 CD cord-015021-pol2qm74 8643 18 and and CC cord-015021-pol2qm74 8643 19 other other JJ cord-015021-pol2qm74 8643 20 or or CC cord-015021-pol2qm74 8643 21 unknown unknown JJ cord-015021-pol2qm74 8643 22 causes cause NNS cord-015021-pol2qm74 8643 23 in in IN cord-015021-pol2qm74 8643 24 5 5 CD cord-015021-pol2qm74 8643 25 patients patient NNS cord-015021-pol2qm74 8643 26 . . . cord-015021-pol2qm74 8644 1 Five five CD cord-015021-pol2qm74 8644 2 of of IN cord-015021-pol2qm74 8644 3 11 11 CD cord-015021-pol2qm74 8644 4 patients patient NNS cord-015021-pol2qm74 8644 5 with with IN cord-015021-pol2qm74 8644 6 nAP nap RB cord-015021-pol2qm74 8644 7 died die VBD cord-015021-pol2qm74 8644 8 early early RB cord-015021-pol2qm74 8644 9 ( ( -LRB- cord-015021-pol2qm74 8644 10 n n NN cord-015021-pol2qm74 8644 11 = = NN cord-015021-pol2qm74 8644 12 l l NN cord-015021-pol2qm74 8644 13 ) ) -RRB- cord-015021-pol2qm74 8644 14 or or CC cord-015021-pol2qm74 8644 15 of of IN cord-015021-pol2qm74 8644 16 late late JJ cord-015021-pol2qm74 8644 17 septic septic JJ cord-015021-pol2qm74 8644 18 complications complication NNS cord-015021-pol2qm74 8644 19 . . . cord-015021-pol2qm74 8645 1 None none NN cord-015021-pol2qm74 8645 2 died die VBD cord-015021-pol2qm74 8645 3 of of IN cord-015021-pol2qm74 8645 4 iAP.The iAP.The NNP cord-015021-pol2qm74 8645 5 peak peak NN cord-015021-pol2qm74 8645 6 of of IN cord-015021-pol2qm74 8645 7 cytnkine cytnkine JJ cord-015021-pol2qm74 8645 8 level level NN cord-015021-pol2qm74 8645 9 in in IN cord-015021-pol2qm74 8645 10 the the DT cord-015021-pol2qm74 8645 11 first first JJ cord-015021-pol2qm74 8645 12 three three CD cord-015021-pol2qm74 8645 13 days day NNS cord-015021-pol2qm74 8645 14 of of IN cord-015021-pol2qm74 8645 15 hospitalisation hospitalisation NN cord-015021-pol2qm74 8645 16 was be VBD cord-015021-pol2qm74 8645 17 used use VBN cord-015021-pol2qm74 8645 18 for for IN cord-015021-pol2qm74 8645 19 calculation calculation NN cord-015021-pol2qm74 8645 20 . . . cord-015021-pol2qm74 8646 1 RI RI NNP cord-015021-pol2qm74 8646 2 was be VBD cord-015021-pol2qm74 8646 3 diagnosed diagnose VBN cord-015021-pol2qm74 8646 4 in in IN cord-015021-pol2qm74 8646 5 the the DT cord-015021-pol2qm74 8646 6 first first JJ cord-015021-pol2qm74 8646 7 week week NN cord-015021-pol2qm74 8646 8 of of IN cord-015021-pol2qm74 8646 9 hospitalisation hospitalisation NN cord-015021-pol2qm74 8646 10 , , , cord-015021-pol2qm74 8646 11 if if IN cord-015021-pol2qm74 8646 12 oxygenmask oxygenmask NN cord-015021-pol2qm74 8646 13 or or CC cord-015021-pol2qm74 8646 14 iutubation iutubation NN cord-015021-pol2qm74 8646 15 for for IN cord-015021-pol2qm74 8646 16 at at RB cord-015021-pol2qm74 8646 17 least least JJS cord-015021-pol2qm74 8646 18 3 3 CD cord-015021-pol2qm74 8646 19 days day NNS cord-015021-pol2qm74 8646 20 was be VBD cord-015021-pol2qm74 8646 21 nescessary nescessary JJ cord-015021-pol2qm74 8646 22 to to TO cord-015021-pol2qm74 8646 23 treat treat VB cord-015021-pol2qm74 8646 24 arterial arterial JJ cord-015021-pol2qm74 8646 25 hypoxemia hypoxemia NN cord-015021-pol2qm74 8646 26 . . . cord-015021-pol2qm74 8647 1 For for IN cord-015021-pol2qm74 8647 2 statistical statistical JJ cord-015021-pol2qm74 8647 3 analysis analysis NN cord-015021-pol2qm74 8647 4 U u NN cord-015021-pol2qm74 8647 5 - - HYPH cord-015021-pol2qm74 8647 6 Test Test NNP cord-015021-pol2qm74 8647 7 of of IN cord-015021-pol2qm74 8647 8 Wilcoxon Wilcoxon NNP cord-015021-pol2qm74 8647 9 , , , cord-015021-pol2qm74 8647 10 Mann Mann NNP cord-015021-pol2qm74 8647 11 and and CC cord-015021-pol2qm74 8647 12 Whitney Whitney NNP cord-015021-pol2qm74 8647 13 was be VBD cord-015021-pol2qm74 8647 14 applicated applicate VBN cord-015021-pol2qm74 8647 15 . . . cord-015021-pol2qm74 8648 1 The the DT cord-015021-pol2qm74 8648 2 IL-6 IL-6 NNP cord-015021-pol2qm74 8648 3 concentration concentration NN cord-015021-pol2qm74 8648 4 in in IN cord-015021-pol2qm74 8648 5 blood blood NN cord-015021-pol2qm74 8648 6 reached reach VBD cord-015021-pol2qm74 8648 7 up up RP cord-015021-pol2qm74 8648 8 to to IN cord-015021-pol2qm74 8648 9 2600pg 2600pg CD cord-015021-pol2qm74 8648 10 / / SYM cord-015021-pol2qm74 8648 11 ml ml XX cord-015021-pol2qm74 8648 12 in in IN cord-015021-pol2qm74 8648 13 the the DT cord-015021-pol2qm74 8648 14 first first JJ cord-015021-pol2qm74 8648 15 days day NNS cord-015021-pol2qm74 8648 16 depending depend VBG cord-015021-pol2qm74 8648 17 on on IN cord-015021-pol2qm74 8648 18 the the DT cord-015021-pol2qm74 8648 19 severity severity NN cord-015021-pol2qm74 8648 20 of of IN cord-015021-pol2qm74 8648 21 AP AP NNP cord-015021-pol2qm74 8648 22 and and CC cord-015021-pol2qm74 8648 23 dropped drop VBD cord-015021-pol2qm74 8648 24 to to IN cord-015021-pol2qm74 8648 25 almost almost RB cord-015021-pol2qm74 8648 26 zero zero CD cord-015021-pol2qm74 8648 27 in in IN cord-015021-pol2qm74 8648 28 the the DT cord-015021-pol2qm74 8648 29 next next JJ cord-015021-pol2qm74 8648 30 days day NNS cord-015021-pol2qm74 8648 31 , , , cord-015021-pol2qm74 8648 32 independently independently RB cord-015021-pol2qm74 8648 33 of of IN cord-015021-pol2qm74 8648 34 the the DT cord-015021-pol2qm74 8648 35 clinical clinical JJ cord-015021-pol2qm74 8648 36 course course NN cord-015021-pol2qm74 8648 37 . . . cord-015021-pol2qm74 8649 1 The the DT cord-015021-pol2qm74 8649 2 differentiation differentiation NN cord-015021-pol2qm74 8649 3 of of IN cord-015021-pol2qm74 8649 4 i i NN cord-015021-pol2qm74 8649 5 - - HYPH cord-015021-pol2qm74 8649 6 versus versus IN cord-015021-pol2qm74 8649 7 nAP nap RB cord-015021-pol2qm74 8649 8 , , , cord-015021-pol2qm74 8649 9 using use VBG cord-015021-pol2qm74 8649 10 a a DT cord-015021-pol2qm74 8649 11 cutoff cutoff NN cord-015021-pol2qm74 8649 12 - - HYPH cord-015021-pol2qm74 8649 13 line line NN cord-015021-pol2qm74 8649 14 of of IN cord-015021-pol2qm74 8649 15 600 600 CD cord-015021-pol2qm74 8649 16 pg pg NN cord-015021-pol2qm74 8649 17 / / SYM cord-015021-pol2qm74 8649 18 ml ml NNS cord-015021-pol2qm74 8649 19 was be VBD cord-015021-pol2qm74 8649 20 correct correct JJ cord-015021-pol2qm74 8649 21 in in IN cord-015021-pol2qm74 8649 22 20 20 CD cord-015021-pol2qm74 8649 23 patients patient NNS cord-015021-pol2qm74 8649 24 ( ( -LRB- cord-015021-pol2qm74 8649 25 87 87 CD cord-015021-pol2qm74 8649 26 % % NN cord-015021-pol2qm74 8649 27 , , , cord-015021-pol2qm74 8649 28 sensitivity sensitivity NN cord-015021-pol2qm74 8649 29 ( ( -LRB- cord-015021-pol2qm74 8649 30 SE SE NNP cord-015021-pol2qm74 8649 31 ) ) -RRB- cord-015021-pol2qm74 8649 32 : : : cord-015021-pol2qm74 8649 33 82%= 82%= CD cord-015021-pol2qm74 8649 34 specificity specificity NN cord-015021-pol2qm74 8649 35 ( ( -LRB- cord-015021-pol2qm74 8649 36 SP SP NNP cord-015021-pol2qm74 8649 37 ) ) -RRB- cord-015021-pol2qm74 8649 38 : : : cord-015021-pol2qm74 8649 39 91 91 CD cord-015021-pol2qm74 8649 40 % % NN cord-015021-pol2qm74 8649 41 , , , cord-015021-pol2qm74 8649 42 ( ( -LRB- cord-015021-pol2qm74 8649 43 z:0,001 z:0,001 NNP cord-015021-pol2qm74 8649 44 ) ) -RRB- cord-015021-pol2qm74 8649 45 . . . cord-015021-pol2qm74 8650 1 High high JJ cord-015021-pol2qm74 8650 2 levels level NNS cord-015021-pol2qm74 8650 3 of of IN cord-015021-pol2qm74 8650 4 IL-6 IL-6 NNP cord-015021-pol2qm74 8650 5 over over IN cord-015021-pol2qm74 8650 6 500 500 CD cord-015021-pol2qm74 8650 7 pg pg NNP cord-015021-pol2qm74 8650 8 / / SYM cord-015021-pol2qm74 8650 9 ml ml NNS cord-015021-pol2qm74 8650 10 correlated correlate VBD cord-015021-pol2qm74 8650 11 well well RB cord-015021-pol2qm74 8650 12 with with IN cord-015021-pol2qm74 8650 13 the the DT cord-015021-pol2qm74 8650 14 prognosis prognosis NN cord-015021-pol2qm74 8650 15 ifRI ifRI NNP cord-015021-pol2qm74 8650 16 in in IN cord-015021-pol2qm74 8650 17 the the DT cord-015021-pol2qm74 8650 18 first first JJ cord-015021-pol2qm74 8650 19 week week NN cord-015021-pol2qm74 8651 1 ( ( -LRB- cord-015021-pol2qm74 8651 2 Accuracy accuracy NN cord-015021-pol2qm74 8651 3 : : : cord-015021-pol2qm74 8651 4 87 87 CD cord-015021-pol2qm74 8651 5 % % NN cord-015021-pol2qm74 8651 6 , , , cord-015021-pol2qm74 8651 7 SE SE NNP cord-015021-pol2qm74 8651 8 : : : cord-015021-pol2qm74 8651 9 80 80 CD cord-015021-pol2qm74 8651 10 % % NN cord-015021-pol2qm74 8651 11 , , , cord-015021-pol2qm74 8651 12 SP SP NNP cord-015021-pol2qm74 8651 13 : : : cord-015021-pol2qm74 8651 14 100 100 CD cord-015021-pol2qm74 8651 15 % % NN cord-015021-pol2qm74 8651 16 , , , cord-015021-pol2qm74 8651 17 c~ c~ XX cord-015021-pol2qm74 8651 18 : : : cord-015021-pol2qm74 8651 19 0,001 0,001 CD cord-015021-pol2qm74 8651 20 ) ) -RRB- cord-015021-pol2qm74 8651 21 . . . cord-015021-pol2qm74 8652 1 The the DT cord-015021-pol2qm74 8652 2 blood blood NN cord-015021-pol2qm74 8652 3 levels level NNS cord-015021-pol2qm74 8652 4 of of IN cord-015021-pol2qm74 8652 5 IL-8 IL-8 NNP cord-015021-pol2qm74 8652 6 reached reach VBD cord-015021-pol2qm74 8652 7 a a DT cord-015021-pol2qm74 8652 8 maximum maximum NN cord-015021-pol2qm74 8652 9 of of IN cord-015021-pol2qm74 8652 10 1381 1381 CD cord-015021-pol2qm74 8652 11 pg pg NN cord-015021-pol2qm74 8652 12 / / SYM cord-015021-pol2qm74 8652 13 ml ml XX cord-015021-pol2qm74 8652 14 in in IN cord-015021-pol2qm74 8652 15 the the DT cord-015021-pol2qm74 8652 16 first first JJ cord-015021-pol2qm74 8652 17 days day NNS cord-015021-pol2qm74 8652 18 , , , cord-015021-pol2qm74 8652 19 depending depend VBG cord-015021-pol2qm74 8652 20 on on IN cord-015021-pol2qm74 8652 21 the the DT cord-015021-pol2qm74 8652 22 severity severity NN cord-015021-pol2qm74 8652 23 of of IN cord-015021-pol2qm74 8652 24 AP AP NNP cord-015021-pol2qm74 8652 25 , , , cord-015021-pol2qm74 8652 26 and and CC cord-015021-pol2qm74 8652 27 showed show VBD cord-015021-pol2qm74 8652 28 a a DT cord-015021-pol2qm74 8652 29 correlation correlation NN cord-015021-pol2qm74 8652 30 to to IN cord-015021-pol2qm74 8652 31 the the DT cord-015021-pol2qm74 8652 32 clinical clinical JJ cord-015021-pol2qm74 8652 33 course course NN cord-015021-pol2qm74 8652 34 in in IN cord-015021-pol2qm74 8652 35 the the DT cord-015021-pol2qm74 8652 36 following follow VBG cord-015021-pol2qm74 8652 37 days day NNS cord-015021-pol2qm74 8652 38 . . . cord-015021-pol2qm74 8653 1 The the DT cord-015021-pol2qm74 8653 2 peak peak NN cord-015021-pol2qm74 8653 3 of of IN cord-015021-pol2qm74 8653 4 1l,-8 1l,-8 CD cord-015021-pol2qm74 8653 5 blood blood NN cord-015021-pol2qm74 8653 6 levels level NNS cord-015021-pol2qm74 8653 7 indicated indicate VBD cord-015021-pol2qm74 8653 8 correctly correctly RB cord-015021-pol2qm74 8653 9 the the DT cord-015021-pol2qm74 8653 10 severity severity NN cord-015021-pol2qm74 8653 11 of of IN cord-015021-pol2qm74 8653 12 AP AP NNP cord-015021-pol2qm74 8653 13 in in IN cord-015021-pol2qm74 8653 14 18 18 CD cord-015021-pol2qm74 8653 15 out out IN cord-015021-pol2qm74 8653 16 of of IN cord-015021-pol2qm74 8653 17 23 23 CD cord-015021-pol2qm74 8653 18 patients patient NNS cord-015021-pol2qm74 8653 19 using use VBG cord-015021-pol2qm74 8653 20 a a DT cord-015021-pol2qm74 8653 21 cut cut NN cord-015021-pol2qm74 8653 22 offtevel offtevel NN cord-015021-pol2qm74 8653 23 of of IN cord-015021-pol2qm74 8653 24 200 200 CD cord-015021-pol2qm74 8653 25 pglml pglml NNS cord-015021-pol2qm74 8653 26 ( ( -LRB- cord-015021-pol2qm74 8653 27 Accuracy accuracy NN cord-015021-pol2qm74 8653 28 : : : cord-015021-pol2qm74 8653 29 78 78 CD cord-015021-pol2qm74 8653 30 % % NN cord-015021-pol2qm74 8653 31 , , , cord-015021-pol2qm74 8653 32 SE SE NNP cord-015021-pol2qm74 8653 33 : : : cord-015021-pol2qm74 8653 34 82 82 CD cord-015021-pol2qm74 8653 35 % % NN cord-015021-pol2qm74 8653 36 , , , cord-015021-pol2qm74 8653 37 SP SP NNP cord-015021-pol2qm74 8653 38 : : : cord-015021-pol2qm74 8653 39 75 75 CD cord-015021-pol2qm74 8653 40 % % NN cord-015021-pol2qm74 8653 41 , , , cord-015021-pol2qm74 8653 42 ~ ~ CD cord-015021-pol2qm74 8653 43 : : : cord-015021-pol2qm74 8653 44 0,01 0,01 LS cord-015021-pol2qm74 8653 45 ) ) -RRB- cord-015021-pol2qm74 8653 46 . . . cord-015021-pol2qm74 8654 1 There there EX cord-015021-pol2qm74 8654 2 was be VBD cord-015021-pol2qm74 8654 3 no no DT cord-015021-pol2qm74 8654 4 correlation correlation NN cord-015021-pol2qm74 8654 5 between between IN cord-015021-pol2qm74 8654 6 cytokine cytokine JJ cord-015021-pol2qm74 8654 7 blood blood NN cord-015021-pol2qm74 8654 8 levels level NNS cord-015021-pol2qm74 8654 9 and and CC cord-015021-pol2qm74 8654 10 mortality mortality NN cord-015021-pol2qm74 8654 11 , , , cord-015021-pol2qm74 8654 12 Also also RB cord-015021-pol2qm74 8654 13 there there EX cord-015021-pol2qm74 8654 14 seemed seem VBD cord-015021-pol2qm74 8654 15 to to TO cord-015021-pol2qm74 8654 16 be be VB cord-015021-pol2qm74 8654 17 no no DT cord-015021-pol2qm74 8654 18 correlation correlation NN cord-015021-pol2qm74 8654 19 between between IN cord-015021-pol2qm74 8654 20 the the DT cord-015021-pol2qm74 8654 21 levels level NNS cord-015021-pol2qm74 8654 22 of of IN cord-015021-pol2qm74 8654 23 IL-6 IL-6 NNP cord-015021-pol2qm74 8654 24 and and CC cord-015021-pol2qm74 8654 25 IL-8 IL-8 NNP cord-015021-pol2qm74 8654 26 . . . cord-015021-pol2qm74 8655 1 In in IN cord-015021-pol2qm74 8655 2 the the DT cord-015021-pol2qm74 8655 3 bloodsamples bloodsample NNS cord-015021-pol2qm74 8655 4 of of IN cord-015021-pol2qm74 8655 5 five five CD cord-015021-pol2qm74 8655 6 patients patient NNS cord-015021-pol2qm74 8655 7 with with IN cord-015021-pol2qm74 8655 8 i i PRP cord-015021-pol2qm74 8655 9 - - : cord-015021-pol2qm74 8655 10 or or CC cord-015021-pol2qm74 8655 11 nAP nap XX cord-015021-pol2qm74 8656 1 no no UH cord-015021-pol2qm74 8657 1 c~-TNF c~-TNF NNP cord-015021-pol2qm74 8657 2 was be VBD cord-015021-pol2qm74 8657 3 detectable detectable JJ cord-015021-pol2qm74 8657 4 . . . cord-015021-pol2qm74 8658 1 The the DT cord-015021-pol2qm74 8658 2 blood blood NN cord-015021-pol2qm74 8658 3 levels level NNS cord-015021-pol2qm74 8658 4 of of IN cord-015021-pol2qm74 8658 5 IL-6 IL-6 NNP cord-015021-pol2qm74 8658 6 , , , cord-015021-pol2qm74 8658 7 and and CC cord-015021-pol2qm74 8658 8 to to IN cord-015021-pol2qm74 8658 9 a a DT cord-015021-pol2qm74 8658 10 lesser less JJR cord-015021-pol2qm74 8658 11 extent extent NN cord-015021-pol2qm74 8658 12 of of IN cord-015021-pol2qm74 8658 13 [ [ -LRB- cord-015021-pol2qm74 8658 14 L-8 L-8 NNP cord-015021-pol2qm74 8658 15 , , , cord-015021-pol2qm74 8658 16 can can MD cord-015021-pol2qm74 8658 17 predict predict VB cord-015021-pol2qm74 8658 18 the the DT cord-015021-pol2qm74 8658 19 severity severity NN cord-015021-pol2qm74 8658 20 and and CC cord-015021-pol2qm74 8658 21 early early JJ cord-015021-pol2qm74 8658 22 systemic systemic JJ cord-015021-pol2qm74 8658 23 complications complication NNS cord-015021-pol2qm74 8658 24 of of IN cord-015021-pol2qm74 8658 25 AP AP NNP cord-015021-pol2qm74 8658 26 in in IN cord-015021-pol2qm74 8658 27 men man NNS cord-015021-pol2qm74 8658 28 . . . cord-015021-pol2qm74 8659 1 The the DT cord-015021-pol2qm74 8659 2 excessive excessive JJ cord-015021-pol2qm74 8659 3 rise rise NN cord-015021-pol2qm74 8659 4 of of IN cord-015021-pol2qm74 8659 5 cytokines cytokine NNS cord-015021-pol2qm74 8659 6 can can MD cord-015021-pol2qm74 8659 7 be be VB cord-015021-pol2qm74 8659 8 explained explain VBN cord-015021-pol2qm74 8659 9 by by IN cord-015021-pol2qm74 8659 10 the the DT cord-015021-pol2qm74 8659 11 stimulation stimulation NN cord-015021-pol2qm74 8659 12 of of IN cord-015021-pol2qm74 8659 13 immunological immunological JJ cord-015021-pol2qm74 8659 14 cells cell NNS cord-015021-pol2qm74 8659 15 ( ( -LRB- cord-015021-pol2qm74 8659 16 macrophages macrophage NNS cord-015021-pol2qm74 8659 17 , , , cord-015021-pol2qm74 8659 18 lymphocytes lymphocyte NNS cord-015021-pol2qm74 8659 19 and and CC cord-015021-pol2qm74 8659 20 endothelial endothelial JJ cord-015021-pol2qm74 8659 21 cells cell NNS cord-015021-pol2qm74 8659 22 ) ) -RRB- cord-015021-pol2qm74 8659 23 in in IN cord-015021-pol2qm74 8659 24 the the DT cord-015021-pol2qm74 8659 25 course course NN cord-015021-pol2qm74 8659 26 of of IN cord-015021-pol2qm74 8659 27 AP AP NNP cord-015021-pol2qm74 8659 28 . . . cord-015021-pol2qm74 8660 1 Objectives objective NNS cord-015021-pol2qm74 8660 2 : : : cord-015021-pol2qm74 8660 3 In in IN cord-015021-pol2qm74 8660 4 an an DT cord-015021-pol2qm74 8660 5 opossum opossum NN cord-015021-pol2qm74 8660 6 model model NN cord-015021-pol2qm74 8660 7 , , , cord-015021-pol2qm74 8660 8 ligation ligation NN cord-015021-pol2qm74 8660 9 of of IN cord-015021-pol2qm74 8660 10 the the DT cord-015021-pol2qm74 8660 11 sphincter sphincter NN cord-015021-pol2qm74 8660 12 of of IN cord-015021-pol2qm74 8660 13 Oddi Oddi NNP cord-015021-pol2qm74 8660 14 or or CC cord-015021-pol2qm74 8660 15 separate separate JJ cord-015021-pol2qm74 8660 16 ligation ligation NN cord-015021-pol2qm74 8660 17 of of IN cord-015021-pol2qm74 8660 18 the the DT cord-015021-pol2qm74 8660 19 bile bile NN cord-015021-pol2qm74 8660 20 and and CC cord-015021-pol2qm74 8660 21 the the DT cord-015021-pol2qm74 8660 22 pancreatic pancreatic JJ cord-015021-pol2qm74 8660 23 duct duct NN cord-015021-pol2qm74 8660 24 together together RB cord-015021-pol2qm74 8660 25 leads lead VBZ cord-015021-pol2qm74 8660 26 to to IN cord-015021-pol2qm74 8660 27 severe severe JJ cord-015021-pol2qm74 8660 28 haemorrhagic haemorrhagic JJ cord-015021-pol2qm74 8660 29 pancreatffis pancreatffis NN cord-015021-pol2qm74 8660 30 while while IN cord-015021-pol2qm74 8660 31 single single JJ cord-015021-pol2qm74 8660 32 ligation ligation NN cord-015021-pol2qm74 8660 33 of of IN cord-015021-pol2qm74 8660 34 the the DT cord-015021-pol2qm74 8660 35 pancreatic pancreatic JJ cord-015021-pol2qm74 8660 36 duct duct NN cord-015021-pol2qm74 8660 37 causes cause VBZ cord-015021-pol2qm74 8660 38 only only RB cord-015021-pol2qm74 8660 39 an an DT cord-015021-pol2qm74 8660 40 exocdne exocdne NN cord-015021-pol2qm74 8660 41 atrophy atrophy NN cord-015021-pol2qm74 8660 42 . . . cord-015021-pol2qm74 8661 1 Since since IN cord-015021-pol2qm74 8661 2 BO BO NNP cord-015021-pol2qm74 8661 3 has have VBZ cord-015021-pol2qm74 8661 4 been be VBN cord-015021-pol2qm74 8661 5 discussed discuss VBN cord-015021-pol2qm74 8661 6 to to TO cord-015021-pol2qm74 8661 7 be be VB cord-015021-pol2qm74 8661 8 a a DT cord-015021-pol2qm74 8661 9 contdbutor contdbutor NN cord-015021-pol2qm74 8661 10 t¢ t¢ NN cord-015021-pol2qm74 8661 11 , , , cord-015021-pol2qm74 8661 12 RES res NN cord-015021-pol2qm74 8661 13 dysfunction dysfunction NN cord-015021-pol2qm74 8661 14 , , , cord-015021-pol2qm74 8661 15 this this DT cord-015021-pol2qm74 8661 16 may may MD cord-015021-pol2qm74 8661 17 depdve depdve VB cord-015021-pol2qm74 8661 18 the the DT cord-015021-pol2qm74 8661 19 organism organism NN cord-015021-pol2qm74 8661 20 of of IN cord-015021-pol2qm74 8661 21 a a DT cord-015021-pol2qm74 8661 22 potent potent JJ cord-015021-pol2qm74 8661 23 defensive defensive JJ cord-015021-pol2qm74 8661 24 mechanism mechanism NN cord-015021-pol2qm74 8661 25 thus thus RB cord-015021-pol2qm74 8661 26 promoting promote VBG cord-015021-pol2qm74 8661 27 the the DT cord-015021-pol2qm74 8661 28 course course NN cord-015021-pol2qm74 8661 29 of of IN cord-015021-pol2qm74 8661 30 pancreatitis pancreatitis NN cord-015021-pol2qm74 8661 31 . . . cord-015021-pol2qm74 8662 1 The the DT cord-015021-pol2qm74 8662 2 present present JJ cord-015021-pol2qm74 8662 3 study study NN cord-015021-pol2qm74 8662 4 wa wa NNP cord-015021-pol2qm74 8662 5 , , , cord-015021-pol2qm74 8662 6 , , , cord-015021-pol2qm74 8662 7 ; ; : cord-015021-pol2qm74 8662 8 carded card VBD cord-015021-pol2qm74 8662 9 out out RP cord-015021-pol2qm74 8662 10 tc tc NNP cord-015021-pol2qm74 8662 11 develop develop VB cord-015021-pol2qm74 8662 12 a a DT cord-015021-pol2qm74 8662 13 new new JJ cord-015021-pol2qm74 8662 14 method method NN cord-015021-pol2qm74 8662 15 for for IN cord-015021-pol2qm74 8662 16 measuring measure VBG cord-015021-pol2qm74 8662 17 dynamic dynamic JJ cord-015021-pol2qm74 8662 18 liver liver NN cord-015021-pol2qm74 8662 19 RES res NN cord-015021-pol2qm74 8662 20 func func NN cord-015021-pol2qm74 8662 21 .. .. NFP cord-015021-pol2qm74 8662 22 tion tion NN cord-015021-pol2qm74 8662 23 and and CC cord-015021-pol2qm74 8662 24 to to TO cord-015021-pol2qm74 8662 25 test test VB cord-015021-pol2qm74 8662 26 the the DT cord-015021-pol2qm74 8662 27 hypothesis hypothesis NN cord-015021-pol2qm74 8662 28 that that WDT cord-015021-pol2qm74 8662 29 BO BO NNP cord-015021-pol2qm74 8662 30 causes cause VBZ cord-015021-pol2qm74 8662 31 a a DT cord-015021-pol2qm74 8662 32 RES res NN cord-015021-pol2qm74 8662 33 dysfunction dysfunction NN cord-015021-pol2qm74 8662 34 . . . cord-015021-pol2qm74 8663 1 Material Material NNP cord-015021-pol2qm74 8663 2 & & CC cord-015021-pol2qm74 8663 3 Methods Methods NNPS cord-015021-pol2qm74 8663 4 : : : cord-015021-pol2qm74 8663 5 18 18 CD cord-015021-pol2qm74 8663 6 opossums opossum NNS cord-015021-pol2qm74 8663 7 were be VBD cord-015021-pol2qm74 8663 8 randomly randomly RB cord-015021-pol2qm74 8663 9 placed place VBN cord-015021-pol2qm74 8663 10 in in IN cord-015021-pol2qm74 8663 11 three three CD cord-015021-pol2qm74 8663 12 groups group NNS cord-015021-pol2qm74 8663 13 . . . cord-015021-pol2qm74 8664 1 All all DT cord-015021-pol2qm74 8664 2 received receive VBD cord-015021-pol2qm74 8664 3 a a DT cord-015021-pol2qm74 8664 4 central central JJ cord-015021-pol2qm74 8664 5 venous venous JJ cord-015021-pol2qm74 8664 6 line line NN cord-015021-pol2qm74 8664 7 . . . cord-015021-pol2qm74 8665 1 After after IN cord-015021-pol2qm74 8665 2 midline midline JJ cord-015021-pol2qm74 8665 3 laparotomy laparotomy NN cord-015021-pol2qm74 8665 4 , , , cord-015021-pol2qm74 8665 5 a a DT cord-015021-pol2qm74 8665 6 specially specially RB cord-015021-pol2qm74 8665 7 designe0 designe0 NN cord-015021-pol2qm74 8665 8 tourniquet tourniquet NN cord-015021-pol2qm74 8665 9 was be VBD cord-015021-pol2qm74 8665 10 placed place VBN cord-015021-pol2qm74 8665 11 around around IN cord-015021-pol2qm74 8665 12 the the DT cord-015021-pol2qm74 8665 13 common common JJ cord-015021-pol2qm74 8665 14 hepatic hepatic JJ cord-015021-pol2qm74 8665 15 duct duct NN cord-015021-pol2qm74 8665 16 above above IN cord-015021-pol2qm74 8665 17 its -PRON- PRP$ cord-015021-pol2qm74 8665 18 junction junction NN cord-015021-pol2qm74 8665 19 with with IN cord-015021-pol2qm74 8665 20 the the DT cord-015021-pol2qm74 8665 21 pancreatic pancreatic JJ cord-015021-pol2qm74 8665 22 duct duct NN cord-015021-pol2qm74 8665 23 ( ( -LRB- cord-015021-pol2qm74 8665 24 group group NN cord-015021-pol2qm74 8665 25 A A NNP cord-015021-pol2qm74 8665 26 , , , cord-015021-pol2qm74 8665 27 n=6 n=6 JJ cord-015021-pol2qm74 8665 28 ) ) -RRB- cord-015021-pol2qm74 8665 29 , , , cord-015021-pol2qm74 8665 30 around around IN cord-015021-pol2qm74 8665 31 the the DT cord-015021-pol2qm74 8665 32 pancreatic pancreatic JJ cord-015021-pol2qm74 8665 33 duct duct NN cord-015021-pol2qm74 8665 34 ( ( -LRB- cord-015021-pol2qm74 8665 35 group group NN cord-015021-pol2qm74 8665 36 B B NNP cord-015021-pol2qm74 8665 37 , , , cord-015021-pol2qm74 8665 38 n=6 n=6 JJ cord-015021-pol2qm74 8665 39 ) ) -RRB- cord-015021-pol2qm74 8665 40 or or CC cord-015021-pol2qm74 8665 41 around around IN cord-015021-pol2qm74 8665 42 both both DT cord-015021-pol2qm74 8665 43 ducts duct NNS cord-015021-pol2qm74 8665 44 ( ( -LRB- cord-015021-pol2qm74 8665 45 group group NN cord-015021-pol2qm74 8665 46 C C NNP cord-015021-pol2qm74 8665 47 , , , cord-015021-pol2qm74 8665 48 n=6 n=6 NN cord-015021-pol2qm74 8665 49 ) ) -RRB- cord-015021-pol2qm74 8665 50 . . . cord-015021-pol2qm74 8666 1 After after IN cord-015021-pol2qm74 8666 2 one one CD cord-015021-pol2qm74 8666 3 week week NN cord-015021-pol2qm74 8666 4 , , , cord-015021-pol2qm74 8666 5 the the DT cord-015021-pol2qm74 8666 6 tourniquets tourniquet NNS cord-015021-pol2qm74 8666 7 were be VBD cord-015021-pol2qm74 8666 8 closed close VBN cord-015021-pol2qm74 8666 9 . . . cord-015021-pol2qm74 8667 1 Using use VBG cord-015021-pol2qm74 8667 2 a a DT cord-015021-pol2qm74 8667 3 scintillation scintillation NN cord-015021-pol2qm74 8667 4 camera camera NN cord-015021-pol2qm74 8667 5 , , , cord-015021-pol2qm74 8667 6 the the DT cord-015021-pol2qm74 8667 7 liver liver NN cord-015021-pol2qm74 8667 8 uptake uptake NN cord-015021-pol2qm74 8667 9 of of IN cord-015021-pol2qm74 8667 10 Nanocoll Nanocoll NNP cord-015021-pol2qm74 8667 11 , , , cord-015021-pol2qm74 8667 12 a a DT cord-015021-pol2qm74 8667 13 99mTcalbumin 99mtcalbumin CD cord-015021-pol2qm74 8667 14 colloid colloid NN cord-015021-pol2qm74 8667 15 with with IN cord-015021-pol2qm74 8667 16 a a DT cord-015021-pol2qm74 8667 17 diameter diameter NN cord-015021-pol2qm74 8667 18 of of IN cord-015021-pol2qm74 8667 19 25 25 CD cord-015021-pol2qm74 8667 20 nm nm NN cord-015021-pol2qm74 8667 21 , , , cord-015021-pol2qm74 8667 22 was be VBD cord-015021-pol2qm74 8667 23 measured measure VBN cord-015021-pol2qm74 8667 24 before before RB cord-015021-pol2qm74 8667 25 , , , cord-015021-pol2qm74 8667 26 2,5 2,5 CD cord-015021-pol2qm74 8667 27 and and CC cord-015021-pol2qm74 8667 28 6 6 CD cord-015021-pol2qm74 8667 29 days day NNS cord-015021-pol2qm74 8667 30 after after IN cord-015021-pol2qm74 8667 31 the the DT cord-015021-pol2qm74 8667 32 obstruction obstruction NN cord-015021-pol2qm74 8667 33 . . . cord-015021-pol2qm74 8668 1 The the DT cord-015021-pol2qm74 8668 2 curves curve NNS cord-015021-pol2qm74 8668 3 were be VBD cord-015021-pol2qm74 8668 4 analysed analyse VBN cord-015021-pol2qm74 8668 5 by by IN cord-015021-pol2qm74 8668 6 a a DT cord-015021-pol2qm74 8668 7 computer computer NN cord-015021-pol2qm74 8668 8 and and CC cord-015021-pol2qm74 8668 9 two two CD cord-015021-pol2qm74 8668 10 parameters parameter NNS cord-015021-pol2qm74 8668 11 ( ( -LRB- cord-015021-pol2qm74 8668 12 R r NN cord-015021-pol2qm74 8668 13 , , , cord-015021-pol2qm74 8668 14 S S NNP cord-015021-pol2qm74 8668 15 ) ) -RRB- cord-015021-pol2qm74 8668 16 were be VBD cord-015021-pol2qm74 8668 17 calculated calculate VBN cord-015021-pol2qm74 8668 18 using use VBG cord-015021-pol2qm74 8668 19 natural natural JJ cord-015021-pol2qm74 8668 20 logarithmic logarithmic JJ cord-015021-pol2qm74 8668 21 regression regression NN cord-015021-pol2qm74 8668 22 . . . cord-015021-pol2qm74 8669 1 As as IN cord-015021-pol2qm74 8669 2 a a DT cord-015021-pol2qm74 8669 3 common common JJ cord-015021-pol2qm74 8669 4 measure measure NN cord-015021-pol2qm74 8669 5 for for IN cord-015021-pol2qm74 8669 6 RES res NN cord-015021-pol2qm74 8669 7 function function NN cord-015021-pol2qm74 8669 8 , , , cord-015021-pol2qm74 8669 9 the the DT cord-015021-pol2qm74 8669 10 corrected correct VBN cord-015021-pol2qm74 8669 11 granulopexic granulopexic NNP cord-015021-pol2qm74 8669 12 index index NN cord-015021-pol2qm74 8669 13 ( ( -LRB- cord-015021-pol2qm74 8669 14 a a LS cord-015021-pol2qm74 8669 15 ) ) -RRB- cord-015021-pol2qm74 8669 16 wa wa NNP cord-015021-pol2qm74 8669 17 , , , cord-015021-pol2qm74 8669 18 , , , cord-015021-pol2qm74 8669 19 ; ; , cord-015021-pol2qm74 8669 20 determined determine VBN cord-015021-pol2qm74 8669 21 , , , cord-015021-pol2qm74 8669 22 After after IN cord-015021-pol2qm74 8669 23 day day NN cord-015021-pol2qm74 8669 24 6 6 CD cord-015021-pol2qm74 8669 25 , , , cord-015021-pol2qm74 8669 26 the the DT cord-015021-pol2qm74 8669 27 pancreas pancreas NN cord-015021-pol2qm74 8669 28 of of IN cord-015021-pol2qm74 8669 29 each each DT cord-015021-pol2qm74 8669 30 opossum opossum NN cord-015021-pol2qm74 8669 31 was be VBD cord-015021-pol2qm74 8669 32 searched search VBN cord-015021-pol2qm74 8669 33 for for IN cord-015021-pol2qm74 8669 34 necrosis necrosis NN cord-015021-pol2qm74 8669 35 by by IN cord-015021-pol2qm74 8669 36 morphometdc morphometdc NN cord-015021-pol2qm74 8669 37 methods method NNS cord-015021-pol2qm74 8669 38 . . . cord-015021-pol2qm74 8670 1 Results result NNS cord-015021-pol2qm74 8670 2 : : : cord-015021-pol2qm74 8671 1 All all DT cord-015021-pol2qm74 8671 2 animals animal NNS cord-015021-pol2qm74 8671 3 survived survive VBD cord-015021-pol2qm74 8671 4 till till IN cord-015021-pol2qm74 8671 5 day day NN cord-015021-pol2qm74 8671 6 6 6 CD cord-015021-pol2qm74 8671 7 . . . cord-015021-pol2qm74 8672 1 The the DT cord-015021-pol2qm74 8672 2 opossums opossum NNS cord-015021-pol2qm74 8672 3 in in IN cord-015021-pol2qm74 8672 4 groups group NNS cord-015021-pol2qm74 8672 5 A A NNP cord-015021-pol2qm74 8672 6 & & CC cord-015021-pol2qm74 8672 7 8 8 CD cord-015021-pol2qm74 8672 8 had have VBD cord-015021-pol2qm74 8672 9 a a DT cord-015021-pol2qm74 8672 10 macro macro NN cord-015021-pol2qm74 8672 11 - - HYPH cord-015021-pol2qm74 8672 12 and and CC cord-015021-pol2qm74 8672 13 microscopic microscopic JJ cord-015021-pol2qm74 8672 14 normal normal JJ cord-015021-pol2qm74 8672 15 pancreas pancrea NNS cord-015021-pol2qm74 8672 16 , , , cord-015021-pol2qm74 8672 17 while while IN cord-015021-pol2qm74 8672 18 those those DT cord-015021-pol2qm74 8672 19 in in IN cord-015021-pol2qm74 8672 20 group group NN cord-015021-pol2qm74 8672 21 C C NNP cord-015021-pol2qm74 8672 22 showed show VBD cord-015021-pol2qm74 8672 23 a a DT cord-015021-pol2qm74 8672 24 severe severe JJ cord-015021-pol2qm74 8672 25 hemorrhagic hemorrhagic JJ cord-015021-pol2qm74 8672 26 pancreatitis pancreatitis NN cord-015021-pol2qm74 8672 27 . . . cord-015021-pol2qm74 8673 1 The the DT cord-015021-pol2qm74 8673 2 granuinpexic granuinpexic NNP cord-015021-pol2qm74 8673 3 index index NN cord-015021-pol2qm74 8673 4 showed show VBD cord-015021-pol2qm74 8673 5 a a DT cord-015021-pol2qm74 8673 6 significan~ significan~ NNP cord-015021-pol2qm74 8673 7 change change NN cord-015021-pol2qm74 8673 8 to to IN cord-015021-pol2qm74 8673 9 the the DT cord-015021-pol2qm74 8673 10 worse bad JJR cord-015021-pol2qm74 8673 11 starting start VBG cord-015021-pol2qm74 8673 12 at at IN cord-015021-pol2qm74 8673 13 day day NN cord-015021-pol2qm74 8673 14 5 5 CD cord-015021-pol2qm74 8673 15 in in IN cord-015021-pol2qm74 8673 16 group group NN cord-015021-pol2qm74 8673 17 A A NNP cord-015021-pol2qm74 8673 18 & & CC cord-015021-pol2qm74 8673 19 B b NN cord-015021-pol2qm74 8674 1 ( ( -LRB- cord-015021-pol2qm74 8674 2 p p NN cord-015021-pol2qm74 8674 3 < < XX cord-015021-pol2qm74 8674 4 O,05 o,05 NN cord-015021-pol2qm74 8674 5 ) ) -RRB- cord-015021-pol2qm74 8675 1 and and CC cord-015021-pol2qm74 8675 2 at at IN cord-015021-pol2qm74 8675 3 day day NN cord-015021-pol2qm74 8675 4 2 2 CD cord-015021-pol2qm74 8675 5 it~ it~ NNP cord-015021-pol2qm74 8675 6 group group NN cord-015021-pol2qm74 8675 7 C C NNP cord-015021-pol2qm74 8675 8 ( ( -LRB- cord-015021-pol2qm74 8675 9 p<0,Ol p<0,ol NN cord-015021-pol2qm74 8675 10 ) ) -RRB- cord-015021-pol2qm74 8675 11 . . . cord-015021-pol2qm74 8676 1 At at IN cord-015021-pol2qm74 8676 2 day day NN cord-015021-pol2qm74 8676 3 6 6 CD cord-015021-pol2qm74 8676 4 , , , cord-015021-pol2qm74 8676 5 RES res NN cord-015021-pol2qm74 8676 6 function function NN cord-015021-pol2qm74 8676 7 in in IN cord-015021-pol2qm74 8676 8 group group NN cord-015021-pol2qm74 8676 9 C C NNP cord-015021-pol2qm74 8676 10 was be VBD cord-015021-pol2qm74 8676 11 significantly significantly RB cord-015021-pol2qm74 8676 12 worse bad JJR cord-015021-pol2qm74 8676 13 than than IN cord-015021-pol2qm74 8676 14 that that DT cord-015021-pol2qm74 8676 15 in in IN cord-015021-pol2qm74 8676 16 group group NN cord-015021-pol2qm74 8676 17 A A NNP cord-015021-pol2qm74 8676 18 & & CC cord-015021-pol2qm74 8676 19 B B NNP cord-015021-pol2qm74 8676 20 ( ( -LRB- cord-015021-pol2qm74 8676 21 p<0,01 p<0,01 NN cord-015021-pol2qm74 8676 22 ) ) -RRB- cord-015021-pol2qm74 8676 23 . . . cord-015021-pol2qm74 8677 1 The the DT cord-015021-pol2qm74 8677 2 regression regression NN cord-015021-pol2qm74 8677 3 parameter parameter NN cord-015021-pol2qm74 8677 4 R r NN cord-015021-pol2qm74 8677 5 showed show VBD cord-015021-pol2qm74 8677 6 no no DT cord-015021-pol2qm74 8677 7 significant significant JJ cord-015021-pol2qm74 8677 8 change change NN cord-015021-pol2qm74 8677 9 in in IN cord-015021-pol2qm74 8677 10 groups group NNS cord-015021-pol2qm74 8677 11 A A NNP cord-015021-pol2qm74 8677 12 & & CC cord-015021-pol2qm74 8677 13 B B NNP cord-015021-pol2qm74 8677 14 , , , cord-015021-pol2qm74 8677 15 but but CC cord-015021-pol2qm74 8677 16 a a DT cord-015021-pol2qm74 8677 17 highly highly RB cord-015021-pol2qm74 8677 18 significant significant JJ cord-015021-pol2qm74 8677 19 decrease decrease NN cord-015021-pol2qm74 8677 20 in in IN cord-015021-pol2qm74 8677 21 group group NN cord-015021-pol2qm74 8677 22 C c NN cord-015021-pol2qm74 8677 23 starting start VBG cord-015021-pol2qm74 8677 24 at at IN cord-015021-pol2qm74 8677 25 day day NN cord-015021-pol2qm74 8677 26 2 2 CD cord-015021-pol2qm74 8677 27 ( ( -LRB- cord-015021-pol2qm74 8677 28 p<0.005 p<0.005 JJ cord-015021-pol2qm74 8677 29 ) ) -RRB- cord-015021-pol2qm74 8677 30 , , , cord-015021-pol2qm74 8677 31 thus thus RB cord-015021-pol2qm74 8677 32 showing show VBG cord-015021-pol2qm74 8677 33 a a DT cord-015021-pol2qm74 8677 34 dysfunction dysfunction NN cord-015021-pol2qm74 8677 35 of of IN cord-015021-pol2qm74 8677 36 the the DT cord-015021-pol2qm74 8677 37 hepatic hepatic JJ cord-015021-pol2qm74 8677 38 RES res NN cord-015021-pol2qm74 8677 39 . . . cord-015021-pol2qm74 8678 1 Conclusions conclusion NNS cord-015021-pol2qm74 8678 2 : : : cord-015021-pol2qm74 8679 1 Obstruction obstruction NN cord-015021-pol2qm74 8679 2 of of IN cord-015021-pol2qm74 8679 3 the the DT cord-015021-pol2qm74 8679 4 hepatic hepatic JJ cord-015021-pol2qm74 8679 5 or or CC cord-015021-pol2qm74 8679 6 pancreatic pancreatic JJ cord-015021-pol2qm74 8679 7 duct duct NN cord-015021-pol2qm74 8679 8 alone alone RB cord-015021-pol2qm74 8679 9 does do VBZ cord-015021-pol2qm74 8679 10 no no DT cord-015021-pol2qm74 8679 11 { { -LRB- cord-015021-pol2qm74 8679 12 result result VB cord-015021-pol2qm74 8679 13 in in IN cord-015021-pol2qm74 8679 14 immediate immediate JJ cord-015021-pol2qm74 8679 15 dysfunction dysfunction NN cord-015021-pol2qm74 8679 16 of of IN cord-015021-pol2qm74 8679 17 the the DT cord-015021-pol2qm74 8679 18 hepatic hepatic JJ cord-015021-pol2qm74 8679 19 RES res NN cord-015021-pol2qm74 8679 20 , , , cord-015021-pol2qm74 8679 21 while while IN cord-015021-pol2qm74 8679 22 obstruction obstruction NN cord-015021-pol2qm74 8679 23 of of IN cord-015021-pol2qm74 8679 24 beth beth NNP cord-015021-pol2qm74 8679 25 ducts duct NNS cord-015021-pol2qm74 8679 26 does do VBZ cord-015021-pol2qm74 8679 27 . . . cord-015021-pol2qm74 8680 1 Because because IN cord-015021-pol2qm74 8680 2 only only JJ cord-015021-pol2qm74 8680 3 ligation ligation NN cord-015021-pol2qm74 8680 4 of of IN cord-015021-pol2qm74 8680 5 both both DT cord-015021-pol2qm74 8680 6 ducts duct NNS cord-015021-pol2qm74 8680 7 is be VBZ cord-015021-pol2qm74 8680 8 followed follow VBN cord-015021-pol2qm74 8680 9 by by IN cord-015021-pol2qm74 8680 10 a a DT cord-015021-pol2qm74 8680 11 severe severe JJ cord-015021-pol2qm74 8680 12 hereof hereof NN cord-015021-pol2qm74 8680 13 .. .. . cord-015021-pol2qm74 8681 1 rhagic rhagic NNP cord-015021-pol2qm74 8681 2 pancreatitis pancreatitis NN cord-015021-pol2qm74 8681 3 , , , cord-015021-pol2qm74 8681 4 RES res NN cord-015021-pol2qm74 8681 5 dysfunction dysfunction NN cord-015021-pol2qm74 8681 6 could could MD cord-015021-pol2qm74 8681 7 be be VB cord-015021-pol2qm74 8681 8 an an DT cord-015021-pol2qm74 8681 9 important important JJ cord-015021-pol2qm74 8681 10 factor factor NN cord-015021-pol2qm74 8681 11 in in IN cord-015021-pol2qm74 8681 12 the the DT cord-015021-pol2qm74 8681 13 pathogenesis pathogenesis NN cord-015021-pol2qm74 8681 14 of of IN cord-015021-pol2qm74 8681 15 pancreatitis pancreatitis NN cord-015021-pol2qm74 8681 16 and and CC cord-015021-pol2qm74 8681 17 resulting result VBG cord-015021-pol2qm74 8681 18 organ organ NN cord-015021-pol2qm74 8681 19 failure failure NN cord-015021-pol2qm74 8681 20 . . . cord-015021-pol2qm74 8682 1 Logarithmic Logarithmic NNP cord-015021-pol2qm74 8682 2 regressinrL regressinrL NNP cord-015021-pol2qm74 8682 3 has have VBZ cord-015021-pol2qm74 8682 4 proven prove VBN cord-015021-pol2qm74 8682 5 to to TO cord-015021-pol2qm74 8682 6 be be VB cord-015021-pol2qm74 8682 7 a a DT cord-015021-pol2qm74 8682 8 valuable valuable JJ cord-015021-pol2qm74 8682 9 tool tool NN cord-015021-pol2qm74 8682 10 to to TO cord-015021-pol2qm74 8682 11 analyse analyse VB cord-015021-pol2qm74 8682 12 dynamic dynamic JJ cord-015021-pol2qm74 8682 13 hepatic hepatic JJ cord-015021-pol2qm74 8682 14 RES res NN cord-015021-pol2qm74 8682 15 function function NN cord-015021-pol2qm74 8682 16 . . . cord-015021-pol2qm74 8683 1 ( ( -LRB- cord-015021-pol2qm74 8683 2 B6 B6 NNP cord-015021-pol2qm74 8683 3 ) ) -RRB- cord-015021-pol2qm74 8683 4 in in IN cord-015021-pol2qm74 8683 5 Lewis Lewis NNP cord-015021-pol2qm74 8683 6 rats rat NNS cord-015021-pol2qm74 8683 7 weighing weigh VBG cord-015021-pol2qm74 8683 8 220 220 CD cord-015021-pol2qm74 8683 9 - - SYM cord-015021-pol2qm74 8683 10 250 250 CD cord-015021-pol2qm74 8683 11 g g NN cord-015021-pol2qm74 8683 12 . . . cord-015021-pol2qm74 8684 1 There there EX cord-015021-pol2qm74 8684 2 were be VBD cord-015021-pol2qm74 8684 3 five five CD cord-015021-pol2qm74 8684 4 groups group NNS cord-015021-pol2qm74 8684 5 : : : cord-015021-pol2qm74 8685 1 group group NNP cord-015021-pol2qm74 8685 2 A A NNP cord-015021-pol2qm74 8685 3 ( ( -LRB- cord-015021-pol2qm74 8685 4 n=14 n=14 NN cord-015021-pol2qm74 8685 5 ) ) -RRB- cord-015021-pol2qm74 8685 6 were be VBD cord-015021-pol2qm74 8685 7 untreated untreated JJ cord-015021-pol2qm74 8685 8 controls control NNS cord-015021-pol2qm74 8685 9 ; ; : cord-015021-pol2qm74 8685 10 group group NN cord-015021-pol2qm74 8685 11 B B NNP cord-015021-pol2qm74 8685 12 ( ( -LRB- cord-015021-pol2qm74 8685 13 n=7 n=7 NNS cord-015021-pol2qm74 8685 14 ) ) -RRB- cord-015021-pol2qm74 8685 15 were be VBD cord-015021-pol2qm74 8685 16 given give VBN cord-015021-pol2qm74 8685 17 isotonic isotonic JJ cord-015021-pol2qm74 8685 18 saline saline NN cord-015021-pol2qm74 8685 19 intraperitoneally intraperitoneally RB cord-015021-pol2qm74 8685 20 and and CC cord-015021-pol2qm74 8685 21 observed observe VBD cord-015021-pol2qm74 8685 22 for for IN cord-015021-pol2qm74 8685 23 48 48 CD cord-015021-pol2qm74 8685 24 hours hour NNS cord-015021-pol2qm74 8685 25 ; ; : cord-015021-pol2qm74 8685 26 group group NN cord-015021-pol2qm74 8685 27 C C NNP cord-015021-pol2qm74 8685 28 ( ( -LRB- cord-015021-pol2qm74 8685 29 n=7 n=7 NNP cord-015021-pol2qm74 8685 30 ) ) -RRB- cord-015021-pol2qm74 8685 31 2 2 CD cord-015021-pol2qm74 8685 32 ml ml NN cord-015021-pol2qm74 8685 33 x x NN cord-015021-pol2qm74 8685 34 108 108 CD cord-015021-pol2qm74 8685 35 E. E. NNP cord-015021-pol2qm74 8685 36 coli coli NNS cord-015021-pol2qm74 8685 37 intraperitoneally intraperitoneally RB cord-015021-pol2qm74 8685 38 and and CC cord-015021-pol2qm74 8685 39 observed observe VBD cord-015021-pol2qm74 8685 40 for for IN cord-015021-pol2qm74 8685 41 48 48 CD cord-015021-pol2qm74 8685 42 hours hour NNS cord-015021-pol2qm74 8685 43 ; ; : cord-015021-pol2qm74 8685 44 group group NN cord-015021-pol2qm74 8685 45 D D NNP cord-015021-pol2qm74 8685 46 ( ( -LRB- cord-015021-pol2qm74 8685 47 n=7 n=7 NNS cord-015021-pol2qm74 8685 48 ) ) -RRB- cord-015021-pol2qm74 8685 49 were be VBD cord-015021-pol2qm74 8685 50 given give VBN cord-015021-pol2qm74 8685 51 4 4 CD cord-015021-pol2qm74 8685 52 ml ml NN cord-015021-pol2qm74 8685 53 x x NN cord-015021-pol2qm74 8685 54 108 108 CD cord-015021-pol2qm74 8685 55 E. E. NNP cord-015021-pol2qm74 8685 56 coli coli NNS cord-015021-pol2qm74 8685 57 and and CC cord-015021-pol2qm74 8685 58 observed observe VBD cord-015021-pol2qm74 8685 59 for for IN cord-015021-pol2qm74 8685 60 48 48 CD cord-015021-pol2qm74 8685 61 hours hour NNS cord-015021-pol2qm74 8685 62 ; ; : cord-015021-pol2qm74 8685 63 group group NN cord-015021-pol2qm74 8685 64 E E NNP cord-015021-pol2qm74 8685 65 ( ( -LRB- cord-015021-pol2qm74 8685 66 n=7 n=7 NNS cord-015021-pol2qm74 8685 67 ) ) -RRB- cord-015021-pol2qm74 8685 68 4 4 CD cord-015021-pol2qm74 8685 69 ml ml NN cord-015021-pol2qm74 8685 70 x x NN cord-015021-pol2qm74 8685 71 i08 i08 NNP cord-015021-pol2qm74 8685 72 E. E. NNP cord-015021-pol2qm74 8685 73 coli coli NNS cord-015021-pol2qm74 8685 74 and and CC cord-015021-pol2qm74 8685 75 observed observe VBD cord-015021-pol2qm74 8685 76 for for IN cord-015021-pol2qm74 8685 77 24 24 CD cord-015021-pol2qm74 8685 78 hours hour NNS cord-015021-pol2qm74 8685 79 , , , cord-015021-pol2qm74 8685 80 The the DT cord-015021-pol2qm74 8685 81 rats rat NNS cord-015021-pol2qm74 8685 82 were be VBD cord-015021-pol2qm74 8685 83 than than IN cord-015021-pol2qm74 8685 84 killed kill VBN cord-015021-pol2qm74 8685 85 , , , cord-015021-pol2qm74 8685 86 the the DT cord-015021-pol2qm74 8685 87 spleens spleen NNS cord-015021-pol2qm74 8685 88 were be VBD cord-015021-pol2qm74 8685 89 removed remove VBN cord-015021-pol2qm74 8685 90 and and CC cord-015021-pol2qm74 8685 91 heparinised heparinised JJ cord-015021-pol2qm74 8685 92 blood blood NN cord-015021-pol2qm74 8685 93 taken take VBN cord-015021-pol2qm74 8685 94 for for IN cord-015021-pol2qm74 8685 95 immunological immunological JJ cord-015021-pol2qm74 8685 96 tests test NNS cord-015021-pol2qm74 8685 97 . . . cord-015021-pol2qm74 8686 1 Total total JJ cord-015021-pol2qm74 8686 2 T T NNP cord-015021-pol2qm74 8686 3 - - HYPH cord-015021-pol2qm74 8686 4 ceils ceils NNP cord-015021-pol2qm74 8686 5 , , , cord-015021-pol2qm74 8686 6 helper helper NN cord-015021-pol2qm74 8686 7 T T NNP cord-015021-pol2qm74 8686 8 - - HYPH cord-015021-pol2qm74 8686 9 ceils ceils NNP cord-015021-pol2qm74 8686 10 , , , cord-015021-pol2qm74 8686 11 suppressor suppressor NN cord-015021-pol2qm74 8686 12 T t NN cord-015021-pol2qm74 8686 13 - - HYPH cord-015021-pol2qm74 8686 14 cells cell NNS cord-015021-pol2qm74 8686 15 , , , cord-015021-pol2qm74 8686 16 monocytes monocyte NNS cord-015021-pol2qm74 8686 17 , , , cord-015021-pol2qm74 8686 18 and and CC cord-015021-pol2qm74 8686 19 the the DT cord-015021-pol2qm74 8686 20 interleukin interleukin NN cord-015021-pol2qm74 8686 21 2 2 CD cord-015021-pol2qm74 8686 22 receptor receptor NN cord-015021-pol2qm74 8686 23 were be VBD cord-015021-pol2qm74 8686 24 determined determine VBN cord-015021-pol2qm74 8686 25 by by IN cord-015021-pol2qm74 8686 26 monoclonal monoclonal JJ cord-015021-pol2qm74 8686 27 antibodies antibody NNS cord-015021-pol2qm74 8686 28 , , , cord-015021-pol2qm74 8686 29 indirect indirect JJ cord-015021-pol2qm74 8686 30 immunfluorescence immunfluorescence NN cord-015021-pol2qm74 8686 31 , , , cord-015021-pol2qm74 8686 32 and and CC cord-015021-pol2qm74 8686 33 flow flow NN cord-015021-pol2qm74 8686 34 cytometry cytometry NN cord-015021-pol2qm74 8686 35 ( ( -LRB- cord-015021-pol2qm74 8686 36 FACS FACS NNP cord-015021-pol2qm74 8686 37 analyser analyser NN cord-015021-pol2qm74 8686 38 11 11 CD cord-015021-pol2qm74 8686 39 ) ) -RRB- cord-015021-pol2qm74 8686 40 . . . cord-015021-pol2qm74 8687 1 Statistical statistical JJ cord-015021-pol2qm74 8687 2 analysis analysis NN cord-015021-pol2qm74 8687 3 was be VBD cord-015021-pol2qm74 8687 4 by by IN cord-015021-pol2qm74 8687 5 the the DT cord-015021-pol2qm74 8687 6 t t NNP cord-015021-pol2qm74 8687 7 test test NN cord-015021-pol2qm74 8687 8 on on IN cord-015021-pol2qm74 8687 9 rank rank NN cord-015021-pol2qm74 8687 10 transformed transform VBN cord-015021-pol2qm74 8687 11 data datum NNS cord-015021-pol2qm74 8687 12 . . . cord-015021-pol2qm74 8688 1 In in IN cord-015021-pol2qm74 8688 2 group group NN cord-015021-pol2qm74 8688 3 B b NN cord-015021-pol2qm74 8688 4 ( ( -LRB- cord-015021-pol2qm74 8688 5 isotonic isotonic JJ cord-015021-pol2qm74 8688 6 saline saline NN cord-015021-pol2qm74 8688 7 ) ) -RRB- cord-015021-pol2qm74 8688 8 the the DT cord-015021-pol2qm74 8688 9 total total JJ cord-015021-pol2qm74 8688 10 T T NNP cord-015021-pol2qm74 8688 11 - - HYPH cord-015021-pol2qm74 8688 12 ceils ceils NNP cord-015021-pol2qm74 8688 13 increased increase VBD cord-015021-pol2qm74 8688 14 in in IN cord-015021-pol2qm74 8688 15 the the DT cord-015021-pol2qm74 8688 16 blood blood NN cord-015021-pol2qm74 8688 17 ( ( -LRB- cord-015021-pol2qm74 8688 18 p=0,003 p=0,003 NN cord-015021-pol2qm74 8688 19 ) ) -RRB- cord-015021-pol2qm74 8688 20 and and CC cord-015021-pol2qm74 8688 21 spleen spleen NNS cord-015021-pol2qm74 8688 22 ( ( -LRB- cord-015021-pol2qm74 8688 23 p=0,0001 p=0,0001 NNP cord-015021-pol2qm74 8688 24 ) ) -RRB- cord-015021-pol2qm74 8688 25 com com NN cord-015021-pol2qm74 8688 26 pared pare VBN cord-015021-pol2qm74 8688 27 with with IN cord-015021-pol2qm74 8688 28 the the DT cord-015021-pol2qm74 8688 29 untreated untreated JJ cord-015021-pol2qm74 8688 30 rats rat NNS cord-015021-pol2qm74 8688 31 ( ( -LRB- cord-015021-pol2qm74 8688 32 group group NN cord-015021-pol2qm74 8688 33 A A NNP cord-015021-pol2qm74 8688 34 ) ) -RRB- cord-015021-pol2qm74 8689 1 , , , cord-015021-pol2qm74 8689 2 In in IN cord-015021-pol2qm74 8689 3 the the DT cord-015021-pol2qm74 8689 4 groups group NNS cord-015021-pol2qm74 8689 5 with with IN cord-015021-pol2qm74 8689 6 peritonitis peritonitis NN cord-015021-pol2qm74 8689 7 ( ( -LRB- cord-015021-pol2qm74 8689 8 C C NNP cord-015021-pol2qm74 8689 9 , , , cord-015021-pol2qm74 8689 10 D D NNP cord-015021-pol2qm74 8689 11 , , , cord-015021-pol2qm74 8689 12 and and CC cord-015021-pol2qm74 8689 13 E e LS cord-015021-pol2qm74 8689 14 ) ) -RRB- cord-015021-pol2qm74 8689 15 we -PRON- PRP cord-015021-pol2qm74 8689 16 found find VBD cord-015021-pol2qm74 8689 17 highly highly RB cord-015021-pol2qm74 8689 18 significant significant JJ cord-015021-pol2qm74 8689 19 rises rise NNS cord-015021-pol2qm74 8689 20 in in IN cord-015021-pol2qm74 8689 21 suppressor suppressor NN cord-015021-pol2qm74 8689 22 T T NNP cord-015021-pol2qm74 8689 23 - - HYPH cord-015021-pol2qm74 8689 24 cells cell NNS cord-015021-pol2qm74 8689 25 in in IN cord-015021-pol2qm74 8689 26 the the DT cord-015021-pol2qm74 8689 27 blood blood NN cord-015021-pol2qm74 8689 28 and and CC cord-015021-pol2qm74 8689 29 spleen spleen NNS cord-015021-pol2qm74 8689 30 ( ( -LRB- cord-015021-pol2qm74 8689 31 both both DT cord-015021-pol2qm74 8689 32 p<0,0001 p<0,0001 CD cord-015021-pol2qm74 8689 33 ) ) -RRB- cord-015021-pol2qm74 8689 34 compared compare VBN cord-015021-pol2qm74 8689 35 with with IN cord-015021-pol2qm74 8689 36 the the DT cord-015021-pol2qm74 8689 37 non non JJ cord-015021-pol2qm74 8689 38 - - JJ cord-015021-pol2qm74 8689 39 infected infected JJ cord-015021-pol2qm74 8689 40 control control NN cord-015021-pol2qm74 8689 41 groups group NNS cord-015021-pol2qm74 8689 42 A A NNP cord-015021-pol2qm74 8689 43 and and CC cord-015021-pol2qm74 8690 1 B. B. NNP cord-015021-pol2qm74 8690 2 This this DT cord-015021-pol2qm74 8690 3 increase increase NN cord-015021-pol2qm74 8690 4 was be VBD cord-015021-pol2qm74 8690 5 significantly significantly RB cord-015021-pol2qm74 8690 6 higher high JJR cord-015021-pol2qm74 8690 7 in in IN cord-015021-pol2qm74 8690 8 group group NN cord-015021-pol2qm74 8690 9 D d NN cord-015021-pol2qm74 8690 10 than than IN cord-015021-pol2qm74 8690 11 in in IN cord-015021-pol2qm74 8690 12 groups group NNS cord-015021-pol2qm74 8690 13 C C NNP cord-015021-pol2qm74 8690 14 and and CC cord-015021-pol2qm74 8690 15 E. E. NNP cord-015021-pol2qm74 8690 16 As as RB cord-015021-pol2qm74 8690 17 well well RB cord-015021-pol2qm74 8690 18 as as IN cord-015021-pol2qm74 8690 19 other other JJ cord-015021-pol2qm74 8690 20 alterations alteration NNS cord-015021-pol2qm74 8690 21 , , , cord-015021-pol2qm74 8690 22 we -PRON- PRP cord-015021-pol2qm74 8690 23 found find VBD cord-015021-pol2qm74 8690 24 a a DT cord-015021-pol2qm74 8690 25 uniform uniform JJ cord-015021-pol2qm74 8690 26 increase increase NN cord-015021-pol2qm74 8690 27 in in IN cord-015021-pol2qm74 8690 28 the the DT cord-015021-pol2qm74 8690 29 number number NN cord-015021-pol2qm74 8690 30 of of IN cord-015021-pol2qm74 8690 31 T T NNP cord-015021-pol2qm74 8690 32 suppressor suppressor NN cord-015021-pol2qm74 8690 33 ceils ceil NNS cord-015021-pol2qm74 8690 34 in in IN cord-015021-pol2qm74 8690 35 our -PRON- PRP$ cord-015021-pol2qm74 8690 36 model model NN cord-015021-pol2qm74 8690 37 of of IN cord-015021-pol2qm74 8690 38 acute acute JJ cord-015021-pol2qm74 8690 39 peritonitis peritonitis NN cord-015021-pol2qm74 8690 40 that that WDT cord-015021-pol2qm74 8690 41 was be VBD cord-015021-pol2qm74 8690 42 both both DT cord-015021-pol2qm74 8690 43 time time NN cord-015021-pol2qm74 8690 44 and and CC cord-015021-pol2qm74 8690 45 dose dose NN cord-015021-pol2qm74 8690 46 dependent dependent JJ cord-015021-pol2qm74 8690 47 , , , cord-015021-pol2qm74 8690 48 Department Department NNP cord-015021-pol2qm74 8690 49 of of IN cord-015021-pol2qm74 8690 50 Surgery Surgery NNP cord-015021-pol2qm74 8690 51 , , , cord-015021-pol2qm74 8690 52 University University NNP cord-015021-pol2qm74 8690 53 Vienna Vienna NNP cord-015021-pol2qm74 8690 54 , , , cord-015021-pol2qm74 8690 55 AKH AKH NNP cord-015021-pol2qm74 8690 56 Wien Wien NNP cord-015021-pol2qm74 8690 57 , , , cord-015021-pol2qm74 8690 58 W W NNP cord-015021-pol2qm74 8690 59 ~ ~ CD cord-015021-pol2qm74 8690 60 hringer hringer NN cord-015021-pol2qm74 8690 61 Gurtel Gurtel NNP cord-015021-pol2qm74 8690 62 18 18 CD cord-015021-pol2qm74 8690 63 - - SYM cord-015021-pol2qm74 8690 64 20 20 CD cord-015021-pol2qm74 8690 65 , , , cord-015021-pol2qm74 8690 66 1090 1090 CD cord-015021-pol2qm74 8690 67 Wien Wien NNP cord-015021-pol2qm74 8690 68 . . . cord-015021-pol2qm74 8691 1 D~'na~'aics d~'na~'aic NNS cord-015021-pol2qm74 8691 2 of of IN cord-015021-pol2qm74 8691 3 Som~ som~ NN cord-015021-pol2qm74 8692 1 l l NNP cord-015021-pol2qm74 8692 2 ~ ~ NFP cord-015021-pol2qm74 8692 3 mnunologic mnunologic NNP cord-015021-pol2qm74 8692 4 Indices Indices NNPS cord-015021-pol2qm74 8692 5 in in IN cord-015021-pol2qm74 8692 6 Children Children NNP cord-015021-pol2qm74 8692 7 with with IN cord-015021-pol2qm74 8692 8 Abdo;~tinal Abdo;~tinal NNP cord-015021-pol2qm74 8692 9 Shock Shock NNP cord-015021-pol2qm74 8693 1 V.Z.i v.z.i CC cord-015021-pol2qm74 8693 2 ~ ~ NFP cord-015021-pol2qm74 8693 3 ioskalenko ioskalenko NNP cord-015021-pol2qm74 8693 4 , , , cord-015021-pol2qm74 8693 5 S.F.Vesiol$,T.V.P s.f.vesiol$,t.v.p NN cord-015021-pol2qm74 8694 1 ~bina ~bina NNP cord-015021-pol2qm74 8694 2 Serum serum NN cord-015021-pol2qm74 8694 3 ( ( -LRB- cord-015021-pol2qm74 8694 4 IgA,:~I iga,:~i NN cord-015021-pol2qm74 8694 5 , , , cord-015021-pol2qm74 8694 6 G g NN cord-015021-pol2qm74 8694 7 , , , cord-015021-pol2qm74 8694 8 circulating circulate VBG cord-015021-pol2qm74 8694 9 imaune imaune NNP cord-015021-pol2qm74 8694 10 co!~plexes co!~plexes NNP cord-015021-pol2qm74 8694 11 , , , cord-015021-pol2qm74 8694 12 co co VBD cord-015021-pol2qm74 8694 13 : : : cord-015021-pol2qm74 8694 14 apleaentary apleaentary JJ cord-015021-pol2qm74 8694 15 serum serum NN cord-015021-pol2qm74 8694 16 activity activity NN cord-015021-pol2qm74 8694 17 , , , cord-015021-pol2qm74 8694 18 antimesothelialvisceral antimesothelialvisceral JJ cord-015021-pol2qm74 8694 19 and and CC cord-015021-pol2qm74 8694 20 parietal parietal JJ cord-015021-pol2qm74 8694 21 antibodies antibody NNS cord-015021-pol2qm74 8694 22 ) ) -RRB- cord-015021-pol2qm74 8694 23 and and CC cord-015021-pol2qm74 8694 24 cellular cellular JJ cord-015021-pol2qm74 8694 25 ( ( -LRB- cord-015021-pol2qm74 8694 26 i i NN cord-015021-pol2qm74 8694 27 - - HYPH cord-015021-pol2qm74 8694 28 l l NNP cord-015021-pol2qm74 8695 1 ~q ~q NNP cord-015021-pol2qm74 8695 2 ~ ~ NFP cord-015021-pol2qm74 8695 3 hocytes hocytes NNP cord-015021-pol2qm74 8695 4 , , , cord-015021-pol2qm74 8696 1 ~s ~s NNP cord-015021-pol2qm74 8697 1 / / NFP cord-015021-pol2qm74 8698 1 Th th JJ cord-015021-pol2qm74 8698 2 , , , cord-015021-pol2qm74 8698 3 B b NN cord-015021-pol2qm74 8698 4 - - HYPH cord-015021-pol2qm74 8698 5 lyaphoeytes lyaphoeytes NNP cord-015021-pol2qm74 8698 6 , , , cord-015021-pol2qm74 8698 7 i i PRP cord-015021-pol2qm74 8698 8 nLaunoleukosis nLaunoleukosis NNP cord-015021-pol2qm74 8698 9 to to IN cord-015021-pol2qm74 8698 10 aesothelial aesothelial JJ cord-015021-pol2qm74 8698 11 allergens allergen NNS cord-015021-pol2qm74 8698 12 ; ; : cord-015021-pol2qm74 8698 13 spontaneous spontaneous JJ cord-015021-pol2qm74 8698 14 blast blast NN cord-015021-pol2qm74 8698 15 cell cell NN cord-015021-pol2qm74 8698 16 transformation transformation NN cord-015021-pol2qm74 8698 17 to to IN cord-015021-pol2qm74 8698 18 phytohemaaglutinin phytohemaaglutinin NNS cord-015021-pol2qm74 8698 19 and and CC cord-015021-pol2qm74 8698 20 .nesoth<-~lial .nesoth<-~lial CD cord-015021-pol2qm74 8698 21 ~,togen ~,togen NNP cord-015021-pol2qm74 8698 22 ; ; : cord-015021-pol2qm74 8698 23 phagooFtic phagooftic JJ cord-015021-pol2qm74 8698 24 neutrophil neutrophil NN cord-015021-pol2qm74 8698 25 activity activity NN cord-015021-pol2qm74 8698 26 ) ) -RRB- cord-015021-pol2qm74 8699 1 im:~une im:~une NNP cord-015021-pol2qm74 8699 2 indices index NNS cord-015021-pol2qm74 8699 3 v. v. XX cord-015021-pol2qm74 8700 1 ' ' `` cord-015021-pol2qm74 8700 2 ere ere VBP cord-015021-pol2qm74 8700 3 studied study VBN cord-015021-pol2qm74 8700 4 in in IN cord-015021-pol2qm74 8700 5 60 60 CD cord-015021-pol2qm74 8700 6 children child NNS cord-015021-pol2qm74 8700 7 operated operate VBD cord-015021-pol2qm74 8700 8 v v NN cord-015021-pol2qm74 8700 9 : : : cord-015021-pol2qm74 8700 10 ith ith NNP cord-015021-pol2qm74 8700 11 symi symi NNP cord-015021-pol2qm74 8700 12 ~ ~ NFP cord-015021-pol2qm74 8700 13 to'as to'as NNP cord-015021-pol2qm74 8700 14 of of IN cord-015021-pol2qm74 8700 15 abdo abdo NNP cord-015021-pol2qm74 8700 16 ~ ~ NFP cord-015021-pol2qm74 8700 17 ainal ainal NNP cord-015021-pol2qm74 8700 18 shock shock NN cord-015021-pol2qm74 8700 19 . . . cord-015021-pol2qm74 8701 1 , , , cord-015021-pol2qm74 8701 2 ' ' `` cord-015021-pol2qm74 8701 3 ~!-~ ~!-~ NN cord-015021-pol2qm74 8701 4 of of IN cord-015021-pol2qm74 8701 5 them -PRON- PRP cord-015021-pol2qm74 8701 6 had have VBD cord-015021-pol2qm74 8701 7 appendicnlar(26 appendicnlar(26 NNP cord-015021-pol2qm74 8702 1 -1ocalized -1ocalized JJ cord-015021-pol2qm74 8702 2 JO JO NNP cord-015021-pol2qm74 8702 3 - - HYPH cord-015021-pol2qm74 8702 4 diffuse diffuse NNP cord-015021-pol2qm74 8702 5 , , , cord-015021-pol2qm74 8702 6 9-~eneralized 9-~eneralized CD cord-015021-pol2qm74 8702 7 ) ) -RRB- cord-015021-pol2qm74 8702 8 and and CC cord-015021-pol2qm74 8702 9 5-hemoperitoni-~is 5-hemoperitoni-~is LS cord-015021-pol2qm74 8702 10 ( ( -LRB- cord-015021-pol2qm74 8702 11 dull dull JJ cord-015021-pol2qm74 8702 12 abdominal abdominal JJ cord-015021-pol2qm74 8702 13 trau;na trau;na NN cord-015021-pol2qm74 8702 14 with with IN cord-015021-pol2qm74 8702 15 injayy injayy NN cord-015021-pol2qm74 8702 16 of of IN cord-015021-pol2qm74 8702 17 ' ' '' cord-015021-pol2qm74 8702 18 the the DT cord-015021-pol2qm74 8702 19 spleen-4 spleen-4 NNP cord-015021-pol2qm74 8702 20 , , , cord-015021-pol2qm74 8702 21 the the DT cord-015021-pol2qm74 8702 22 spleen spleen NN cord-015021-pol2qm74 8702 23 and and CC cord-015021-pol2qm74 8702 24 liver liver NN cord-015021-pol2qm74 8702 25 - - HYPH cord-015021-pol2qm74 8702 26 q q NN cord-015021-pol2qm74 8702 27 ) ) -RRB- cord-015021-pol2qm74 8703 1 , , , cord-015021-pol2qm74 8703 2 flO flo JJ cord-015021-pol2qm74 8703 3 patients patient NNS cord-015021-pol2qm74 8703 4 tJere tJere NNP cord-015021-pol2qm74 8703 5 operated operate VBD cord-015021-pol2qm74 8703 6 on on IN cord-015021-pol2qm74 8703 7 for for IN cord-015021-pol2qm74 8703 8 co~ co~ XX cord-015021-pol2qm74 8704 1 Iplete Iplete NNP cord-015021-pol2qm74 8704 2 iieus iieu NNS cord-015021-pol2qm74 8704 3 ( ( -LRB- cord-015021-pol2qm74 8704 4 ~-intussnsc.sption ~-intussnsc.sption NN cord-015021-pol2qm74 8704 5 , , , cord-015021-pol2qm74 8704 6 5-com 5-com NNP cord-015021-pol2qm74 8704 7 : : : cord-015021-pol2qm74 8704 8 lissural lissural NNP cord-015021-pol2qm74 8704 9 ileus ileus NNP cord-015021-pol2qm74 8704 10 ) ) -RRB- cord-015021-pol2qm74 8704 11 . . . cord-015021-pol2qm74 8705 1 2he 2he NNP cord-015021-pol2qm74 8706 1 follo~'~ing follo~'~e VBG cord-015021-pol2qm74 8706 2 serum serum NN cord-015021-pol2qm74 8706 3 factors factor NNS cord-015021-pol2qm74 8706 4 : : : cord-015021-pol2qm74 8706 5 cireula:;ing cireula:;e VBG cord-015021-pol2qm74 8706 6 im~ im~ NNP cord-015021-pol2qm74 8707 1 aune aune NNP cord-015021-pol2qm74 8707 2 complexes complex NNS cord-015021-pol2qm74 8707 3 and and CC cord-015021-pol2qm74 8707 4 ~).esothelial ~).esothelial CD cord-015021-pol2qm74 8707 5 antibodies antibody NNS cord-015021-pol2qm74 8707 6 are be VBP cord-015021-pol2qm74 8707 7 the the DT cord-015021-pol2qm74 8707 8 aost aost NN cord-015021-pol2qm74 8708 1 i~ i~ CD cord-015021-pol2qm74 8709 1 portant portant JJ cord-015021-pol2qm74 8710 1 ~ar~ ~ar~ NNS cord-015021-pol2qm74 8711 1 ers er NNS cord-015021-pol2qm74 8711 2 of of IN cord-015021-pol2qm74 8711 3 the the DT cord-015021-pol2qm74 8711 4 abdominal abdominal JJ cord-015021-pol2qm74 8711 5 shock shock NN cord-015021-pol2qm74 8711 6 course course NN cord-015021-pol2qm74 8711 7 . . . cord-015021-pol2qm74 8712 1 : : : cord-015021-pol2qm74 8713 1 Yith yith VB cord-015021-pol2qm74 8713 2 the the DT cord-015021-pol2qm74 8713 3 progress progress NN cord-015021-pol2qm74 8713 4 of of IN cord-015021-pol2qm74 8713 5 the the DT cord-015021-pol2qm74 8713 6 process process NN cord-015021-pol2qm74 8713 7 the the DT cord-015021-pol2qm74 8713 8 indices index NNS cord-015021-pol2qm74 8713 9 increase increase VBP cord-015021-pol2qm74 8713 10 irresponsive irresponsive JJ cord-015021-pol2qm74 8713 11 of of IN cord-015021-pol2qm74 8713 12 t. t. NNP cord-015021-pol2qm74 8714 1 L L NNP cord-015021-pol2qm74 8714 2 ~ ~ NFP cord-015021-pol2qm74 8714 3 e e XX cord-015021-pol2qm74 8714 4 cha±.aeter cha±.aeter NN cord-015021-pol2qm74 8714 5 of of IN cord-015021-pol2qm74 8714 6 pathology pathology NN cord-015021-pol2qm74 8714 7 . . . cord-015021-pol2qm74 8715 1 In in IN cord-015021-pol2qm74 8715 2 case case NN cord-015021-pol2qm74 8715 3 of of IN cord-015021-pol2qm74 8715 4 ileus ileus NNP cord-015021-pol2qm74 8715 5 regress regress VBP cord-015021-pol2qm74 8715 6 and and CC cord-015021-pol2qm74 8715 7 hemoperitonotis hemoperitonotis NNP cord-015021-pol2qm74 8715 8 an an DT cord-015021-pol2qm74 8715 9 abrupt abrupt JJ cord-015021-pol2qm74 8715 10 drop drop NN cord-015021-pol2qm74 8715 11 in in IN cord-015021-pol2qm74 8715 12 ~he ~he NNP cord-015021-pol2qm74 8715 13 titer titer NN cord-015021-pol2qm74 8715 14 of of IN cord-015021-pol2qm74 8715 15 anti anti NNP cord-015021-pol2qm74 8715 16 ~ ~ NNP cord-015021-pol2qm74 8715 17 aesothelial aesothelial JJ cord-015021-pol2qm74 8715 18 antibodies antibody NNS cord-015021-pol2qm74 8715 19 is be VBZ cord-015021-pol2qm74 8715 20 noted note VBN cord-015021-pol2qm74 8715 21 . . . cord-015021-pol2qm74 8716 1 In in IN cord-015021-pol2qm74 8716 2 bacterial bacterial JJ cord-015021-pol2qm74 8716 3 peritonitis peritonitis NN cord-015021-pol2qm74 8716 4 a a DT cord-015021-pol2qm74 8716 5 high high JJ cord-015021-pol2qm74 8716 6 ~iter ~iter NN cord-015021-pol2qm74 8716 7 of of IN cord-015021-pol2qm74 8716 8 anti anti JJ cord-015021-pol2qm74 8716 9 : : NNP cord-015021-pol2qm74 8716 10 aesothelial aesothelial JJ cord-015021-pol2qm74 8716 11 parietal parietal JJ cord-015021-pol2qm74 8716 12 antibodies antibody NNS cord-015021-pol2qm74 8716 13 in in IN cord-015021-pol2qm74 8716 14 great great JJ cord-015021-pol2qm74 8716 15 dilutions dilution NNS cord-015021-pol2qm74 8717 1 ( ( -LRB- cord-015021-pol2qm74 8717 2 " " `` cord-015021-pol2qm74 8717 3 + + CC cord-015021-pol2qm74 8717 4 + + CC cord-015021-pol2qm74 8718 1 + + CC cord-015021-pol2qm74 8718 2 " " `` cord-015021-pol2qm74 8718 3 , , , cord-015021-pol2qm74 8718 4 " " '' cord-015021-pol2qm74 8719 1 + + CC cord-015021-pol2qm74 8720 1 + + CC cord-015021-pol2qm74 8721 1 + + CC cord-015021-pol2qm74 8721 2 + + CC cord-015021-pol2qm74 8722 1 " " `` cord-015021-pol2qm74 8722 2 -q -q NNS cord-015021-pol2qm74 8722 3 ; ; : cord-015021-pol2qm74 8722 4 720 720 CD cord-015021-pol2qm74 8722 5 ) ) -RRB- cord-015021-pol2qm74 8722 6 persisted persist VBD cord-015021-pol2qm74 8722 7 even even RB cord-015021-pol2qm74 8722 8 in in IN cord-015021-pol2qm74 8722 9 the the DT cord-015021-pol2qm74 8722 10 period period NN cord-015021-pol2qm74 8722 11 of of IN cord-015021-pol2qm74 8722 12 clinical clinical JJ cord-015021-pol2qm74 8722 13 recovery recovery NN cord-015021-pol2qm74 8722 14 . . . cord-015021-pol2qm74 8723 1 Cellular cellular JJ cord-015021-pol2qm74 8723 2 factors factor NNS cord-015021-pol2qm74 8724 1 cham'acterize cham'acterize IN cord-015021-pol2qm74 8724 2 dFnaaics dfnaaic NNS cord-015021-pol2qm74 8724 3 of of IN cord-015021-pol2qm74 8724 4 the the DT cord-015021-pol2qm74 8724 5 abdominal abdominal JJ cord-015021-pol2qm74 8724 6 shock shock NN cord-015021-pol2qm74 8724 7 coulees coulee NNS cord-015021-pol2qm74 8725 1 less less RBR cord-015021-pol2qm74 8725 2 specifically specifically RB cord-015021-pol2qm74 8725 3 Llast Llast NNP cord-015021-pol2qm74 8725 4 cell cell NN cord-015021-pol2qm74 8725 5 transfor transfor NNP cord-015021-pol2qm74 8725 6 ~ ~ NFP cord-015021-pol2qm74 8725 7 aation aation NNP cord-015021-pol2qm74 8725 8 and and CC cord-015021-pol2qm74 8725 9 phagocyue phagocyue NNP cord-015021-pol2qm74 8725 10 neut neut NNP cord-015021-pol2qm74 8726 1 ~ophil ~ophil JJ cord-015021-pol2qm74 8726 2 activit activit NN cord-015021-pol2qm74 8726 3 2 2 CD cord-015021-pol2qm74 8726 4 can can MD cord-015021-pol2qm74 8726 5 inderectly inderectly RB cord-015021-pol2qm74 8726 6 characterize characterize VB cord-015021-pol2qm74 8726 7 transition transition NN cord-015021-pol2qm74 8726 8 of of IN cord-015021-pol2qm74 8726 9 shock shock NN cord-015021-pol2qm74 8726 10 f f NNP cord-015021-pol2qm74 8726 11 ~ ~ NFP cord-015021-pol2qm74 8726 12 orn orn XX cord-015021-pol2qm74 8726 13 reversible reversible JJ cord-015021-pol2qm74 8726 14 into into IN cord-015021-pol2qm74 8726 15 irreversible irreversible JJ cord-015021-pol2qm74 8726 16 phases phase NNS cord-015021-pol2qm74 8726 17 . . . cord-015021-pol2qm74 8727 1 The the DT cord-015021-pol2qm74 8727 2 past past NN cord-015021-pol2qm74 8727 3 SO so JJ cord-015021-pol2qm74 8727 4 years year NNS cord-015021-pol2qm74 8727 5 have have VBP cord-015021-pol2qm74 8727 6 brought bring VBN cord-015021-pol2qm74 8727 7 a a DT cord-015021-pol2qm74 8727 8 number number NN cord-015021-pol2qm74 8727 9 of of IN cord-015021-pol2qm74 8727 10 major major JJ cord-015021-pol2qm74 8727 11 advances advance NNS cord-015021-pol2qm74 8727 12 in in IN cord-015021-pol2qm74 8727 13 burn burn NN cord-015021-pol2qm74 8727 14 care care NN cord-015021-pol2qm74 8727 15 . . . cord-015021-pol2qm74 8728 1 The the DT cord-015021-pol2qm74 8728 2 initial initial JJ cord-015021-pol2qm74 8728 3 advance advance NN cord-015021-pol2qm74 8728 4 was be VBD cord-015021-pol2qm74 8728 5 the the DT cord-015021-pol2qm74 8728 6 discovery discovery NN cord-015021-pol2qm74 8728 7 that that WDT cord-015021-pol2qm74 8728 8 burn burn VBP cord-015021-pol2qm74 8728 9 victims victim NNS cord-015021-pol2qm74 8728 10 required require VBD cord-015021-pol2qm74 8728 11 large large JJ cord-015021-pol2qm74 8728 12 volumes volume NNS cord-015021-pol2qm74 8728 13 of of IN cord-015021-pol2qm74 8728 14 resuscitation resuscitation NN cord-015021-pol2qm74 8728 15 fluid fluid NN cord-015021-pol2qm74 8728 16 in in IN cord-015021-pol2qm74 8728 17 the the DT cord-015021-pol2qm74 8728 18 initial initial JJ cord-015021-pol2qm74 8728 19 24 24 CD cord-015021-pol2qm74 8728 20 hours hour NNS cord-015021-pol2qm74 8728 21 to to TO cord-015021-pol2qm74 8728 22 maintain maintain VB cord-015021-pol2qm74 8728 23 hsmodynamic hsmodynamic JJ cord-015021-pol2qm74 8728 24 stability stability NN cord-015021-pol2qm74 8728 25 , , , cord-015021-pol2qm74 8728 26 This this DT cord-015021-pol2qm74 8728 27 was be VBD cord-015021-pol2qm74 8728 28 followed follow VBN cord-015021-pol2qm74 8728 29 hy hy NNP cord-015021-pol2qm74 8728 30 the the DT cord-015021-pol2qm74 8728 31 dsvelopmsnt dsvelopmsnt NN cord-015021-pol2qm74 8728 32 of of IN cord-015021-pol2qm74 8728 33 topical topical JJ cord-015021-pol2qm74 8728 34 antimicrohlal antimicrohlal NN cord-015021-pol2qm74 8728 35 agents agent NNS cord-015021-pol2qm74 8728 36 to to TO cord-015021-pol2qm74 8728 37 prevent prevent VB cord-015021-pol2qm74 8728 38 end end NN cord-015021-pol2qm74 8728 39 treat treat NN cord-015021-pol2qm74 8728 40 infections infection NNS cord-015021-pol2qm74 8728 41 . . . cord-015021-pol2qm74 8729 1 Next next RB cord-015021-pol2qm74 8729 2 , , , cord-015021-pol2qm74 8729 3 was be VBD cord-015021-pol2qm74 8729 4 the the DT cord-015021-pol2qm74 8729 5 reporting reporting NN cord-015021-pol2qm74 8729 6 that that IN cord-015021-pol2qm74 8729 7 early early JJ cord-015021-pol2qm74 8729 8 excision excision NN cord-015021-pol2qm74 8729 9 of of IN cord-015021-pol2qm74 8729 10 burn burn NN cord-015021-pol2qm74 8729 11 wounds wound NNS cord-015021-pol2qm74 8729 12 , , , cord-015021-pol2qm74 8729 13 with with IN cord-015021-pol2qm74 8729 14 autografting autografting NN cord-015021-pol2qm74 8729 15 of of IN cord-015021-pol2qm74 8729 16 the the DT cord-015021-pol2qm74 8729 17 excised excise VBN cord-015021-pol2qm74 8729 18 wounds wound NNS cord-015021-pol2qm74 8729 19 was be VBD cord-015021-pol2qm74 8729 20 possible possible JJ cord-015021-pol2qm74 8729 21 . . . cord-015021-pol2qm74 8730 1 Finally finally RB cord-015021-pol2qm74 8730 2 , , , cord-015021-pol2qm74 8730 3 was be VBD cord-015021-pol2qm74 8730 4 the the DT cord-015021-pol2qm74 8730 5 identification identification NN cord-015021-pol2qm74 8730 6 of of IN cord-015021-pol2qm74 8730 7 the the DT cord-015021-pol2qm74 8730 8 importance importance NN cord-015021-pol2qm74 8730 9 of of IN cord-015021-pol2qm74 8730 10 aggrsssive aggrsssive JJ cord-015021-pol2qm74 8730 11 nutritional nutritional JJ cord-015021-pol2qm74 8730 12 support support NN cord-015021-pol2qm74 8730 13 for for IN cord-015021-pol2qm74 8730 14 the the DT cord-015021-pol2qm74 8730 15 hypermstabolic hypermstabolic NN cord-015021-pol2qm74 8730 16 burn burn VB cord-015021-pol2qm74 8730 17 patient patient JJ cord-015021-pol2qm74 8730 18 . . . cord-015021-pol2qm74 8731 1 These these DT cord-015021-pol2qm74 8731 2 advances advance NNS cord-015021-pol2qm74 8731 3 have have VBP cord-015021-pol2qm74 8731 4 markedly markedly RB cord-015021-pol2qm74 8731 5 increaesd increaesd JJ cord-015021-pol2qm74 8731 6 survival survival NN cord-015021-pol2qm74 8731 7 rates rate NNS cord-015021-pol2qm74 8731 8 for for IN cord-015021-pol2qm74 8731 9 given give VBN cord-015021-pol2qm74 8731 10 burn burn NN cord-015021-pol2qm74 8731 11 mimes mime NNS cord-015021-pol2qm74 8731 12 , , , cord-015021-pol2qm74 8731 13 s s NNP cord-015021-pol2qm74 8731 14 ~ ~ NNP cord-015021-pol2qm74 8731 15 ch ch NN cord-015021-pol2qm74 8731 16 that that WDT cord-015021-pol2qm74 8731 17 burns burns NNP cord-015021-pol2qm74 8731 18 which which WDT cord-015021-pol2qm74 8731 19 would would MD cord-015021-pol2qm74 8731 20 previously previously RB cord-015021-pol2qm74 8731 21 have have VB cord-015021-pol2qm74 8731 22 been be VBN cord-015021-pol2qm74 8731 23 considered consider VBN cord-015021-pol2qm74 8731 24 to to TO cord-015021-pol2qm74 8731 25 be be VB cord-015021-pol2qm74 8731 26 aniformly aniformly JJ cord-015021-pol2qm74 8731 27 fetal fetal JJ cord-015021-pol2qm74 8731 28 , , , cord-015021-pol2qm74 8731 29 are be VBP cord-015021-pol2qm74 8731 30 now now RB cord-015021-pol2qm74 8731 31 readily readily RB cord-015021-pol2qm74 8731 32 survivable survivable JJ cord-015021-pol2qm74 8731 33 . . . cord-015021-pol2qm74 8732 1 Thsre Thsre NNP cord-015021-pol2qm74 8732 2 remain remain VBP cord-015021-pol2qm74 8732 3 two two CD cord-015021-pol2qm74 8732 4 unsolved unsolved JJ cord-015021-pol2qm74 8732 5 problems problem NNS cord-015021-pol2qm74 8732 6 in in IN cord-015021-pol2qm74 8732 7 burn burn NN cord-015021-pol2qm74 8732 8 care care NN cord-015021-pol2qm74 8732 9 , , , cord-015021-pol2qm74 8732 10 which which WDT cord-015021-pol2qm74 8732 11 are be VBP cord-015021-pol2qm74 8732 12 limiting limit VBG cord-015021-pol2qm74 8732 13 survivability survivability NN cord-015021-pol2qm74 8732 14 cf cf RB cord-015021-pol2qm74 8732 15 burn burn NN cord-015021-pol2qm74 8732 16 patients patient NNS cord-015021-pol2qm74 8732 17 . . . cord-015021-pol2qm74 8733 1 The the DT cord-015021-pol2qm74 8733 2 first first JJ cord-015021-pol2qm74 8733 3 ie ie FW cord-015021-pol2qm74 8733 4 ths ths NN cord-015021-pol2qm74 8733 5 treatment treatment NN cord-015021-pol2qm74 8733 6 of of IN cord-015021-pol2qm74 8733 7 inhalation inhalation NN cord-015021-pol2qm74 8733 8 injury injury NN cord-015021-pol2qm74 8733 9 . . . cord-015021-pol2qm74 8734 1 Ths ths NN cord-015021-pol2qm74 8734 2 sscond sscond NN cord-015021-pol2qm74 8734 3 is be VBZ cord-015021-pol2qm74 8734 4 how how WRB cord-015021-pol2qm74 8734 5 to to TO cord-015021-pol2qm74 8734 6 obtain obtain VB cord-015021-pol2qm74 8734 7 Coverage coverage NN cord-015021-pol2qm74 8734 8 of of IN cord-015021-pol2qm74 8734 9 ths ths NNP cord-015021-pol2qm74 8734 10 maaaivsly maaaivsly NN cord-015021-pol2qm74 8734 11 burned burn VBD cord-015021-pol2qm74 8734 12 patient patient NN cord-015021-pol2qm74 8734 13 , , , cord-015021-pol2qm74 8734 14 who who WP cord-015021-pol2qm74 8734 15 has have VBZ cord-015021-pol2qm74 8734 16 limited limit VBN cord-015021-pol2qm74 8734 17 skin skin NN cord-015021-pol2qm74 8734 18 graft graft NN cord-015021-pol2qm74 8734 19 donor donor NN cord-015021-pol2qm74 8734 20 sites site NNS cord-015021-pol2qm74 8734 21 available available JJ cord-015021-pol2qm74 8734 22 . . . cord-015021-pol2qm74 8735 1 This this DT cord-015021-pol2qm74 8735 2 ssssion ssssion NN cord-015021-pol2qm74 8735 3 will will MD cord-015021-pol2qm74 8735 4 focus focus VB cord-015021-pol2qm74 8735 5 on on IN cord-015021-pol2qm74 8735 6 the the DT cord-015021-pol2qm74 8735 7 new new JJ cord-015021-pol2qm74 8735 8 treatments treatment NNS cord-015021-pol2qm74 8735 9 being be VBG cord-015021-pol2qm74 8735 10 developed develop VBN cord-015021-pol2qm74 8735 11 to to TO cord-015021-pol2qm74 8735 12 obtain obtain VB cord-015021-pol2qm74 8735 13 permanent permanent JJ cord-015021-pol2qm74 8735 14 coverage coverage NN cord-015021-pol2qm74 8735 15 of of IN cord-015021-pol2qm74 8735 16 burn burn NN cord-015021-pol2qm74 8735 17 wounds wound NNS cord-015021-pol2qm74 8735 18 . . . cord-015021-pol2qm74 8736 1 These these DT cord-015021-pol2qm74 8736 2 include include VBP cord-015021-pol2qm74 8736 3 the the DT cord-015021-pol2qm74 8736 4 use use NN cord-015021-pol2qm74 8736 5 of of IN cord-015021-pol2qm74 8736 6 various various JJ cord-015021-pol2qm74 8736 7 tcplcal tcplcal JJ cord-015021-pol2qm74 8736 8 growth growth NN cord-015021-pol2qm74 8736 9 £ £ NN cord-015021-pol2qm74 8736 10 aotore aotore NN cord-015021-pol2qm74 8736 11 which which WDT cord-015021-pol2qm74 8736 12 can can MD cord-015021-pol2qm74 8736 13 Speed speed VB cord-015021-pol2qm74 8736 14 the the DT cord-015021-pol2qm74 8736 15 rate rate NN cord-015021-pol2qm74 8736 16 of of IN cord-015021-pol2qm74 8736 17 reepithelialization reepithelialization NN cord-015021-pol2qm74 8736 18 of of IN cord-015021-pol2qm74 8736 19 wounds wound NNS cord-015021-pol2qm74 8736 20 , , , cord-015021-pol2qm74 8736 21 Both both CC cord-015021-pol2qm74 8736 22 the the DT cord-015021-pol2qm74 8736 23 beneficial beneficial JJ cord-015021-pol2qm74 8736 24 and and CC cord-015021-pol2qm74 8736 25 dstrimental dstrimental JJ cord-015021-pol2qm74 8736 26 effects effect NNS cord-015021-pol2qm74 8736 27 of of IN cord-015021-pol2qm74 8736 28 using use VBG cord-015021-pol2qm74 8736 29 cultured cultured JJ cord-015021-pol2qm74 8736 30 karatinooyte karatinooyte FW cord-015021-pol2qm74 8736 31 preparations preparation NNS cord-015021-pol2qm74 8736 32 , , , cord-015021-pol2qm74 8736 33 to to TO cord-015021-pol2qm74 8736 34 obtain obtain VB cord-015021-pol2qm74 8736 35 in in IN cord-015021-pol2qm74 8736 36 excess excess NN cord-015021-pol2qm74 8736 37 of of IN cord-015021-pol2qm74 8736 38 one one CD cord-015021-pol2qm74 8736 39 squats squat NNS cord-015021-pol2qm74 8736 40 meter meter NN cord-015021-pol2qm74 8736 41 of of IN cord-015021-pol2qm74 8736 42 a a DT cord-015021-pol2qm74 8736 43 pseudoskin pseudoskin FW cord-015021-pol2qm74 8736 44 from from IN cord-015021-pol2qm74 8736 45 a a DT cord-015021-pol2qm74 8736 46 single single JJ cord-015021-pol2qm74 8736 47 fifteen fifteen CD cord-015021-pol2qm74 8736 48 square square JJ cord-015021-pol2qm74 8736 49 centimeter centimeter NN cord-015021-pol2qm74 8736 50 biopsy biopsy NN cord-015021-pol2qm74 8736 51 of of IN cord-015021-pol2qm74 8736 52 unburned unburned JJ cord-015021-pol2qm74 8736 53 skin skin NN cord-015021-pol2qm74 8736 54 , , , cord-015021-pol2qm74 8736 55 will will MD cord-015021-pol2qm74 8736 56 be be VB cord-015021-pol2qm74 8736 57 discussed discuss VBN cord-015021-pol2qm74 8736 58 , , , cord-015021-pol2qm74 8736 59 Finally finally RB cord-015021-pol2qm74 8736 60 , , , cord-015021-pol2qm74 8736 61 the the DT cord-015021-pol2qm74 8736 62 used use VBN cord-015021-pol2qm74 8736 63 for for IN cord-015021-pol2qm74 8736 64 artificlal artificlal JJ cord-015021-pol2qm74 8736 65 dermal dermal JJ cord-015021-pol2qm74 8736 66 preparations preparation NNS cord-015021-pol2qm74 8736 67 will will MD cord-015021-pol2qm74 8736 68 be be VB cord-015021-pol2qm74 8736 69 discussed discuss VBN cord-015021-pol2qm74 8736 70 . . . cord-015021-pol2qm74 8737 1 integumentary integumentary JJ cord-015021-pol2qm74 8737 2 wound wound NN cord-015021-pol2qm74 8737 3 healing healing NN cord-015021-pol2qm74 8737 4 consists consist NNS cord-015021-pol2qm74 8737 5 of of IN cord-015021-pol2qm74 8737 6 simultaneous simultaneous JJ cord-015021-pol2qm74 8737 7 epithelializalion epithelializalion NN cord-015021-pol2qm74 8737 8 and and CC cord-015021-pol2qm74 8737 9 contraction contraction NN cord-015021-pol2qm74 8737 10 . . . cord-015021-pol2qm74 8738 1 Not not RB cord-015021-pol2qm74 8738 2 long long RB cord-015021-pol2qm74 8738 3 ago ago RB cord-015021-pol2qm74 8738 4 , , , cord-015021-pol2qm74 8738 5 it -PRON- PRP cord-015021-pol2qm74 8738 6 was be VBD cord-015021-pol2qm74 8738 7 thought think VBN cord-015021-pol2qm74 8738 8 that that IN cord-015021-pol2qm74 8738 9 healing healing NN cord-015021-pol2qm74 8738 10 proceeds proceed NNS cord-015021-pol2qm74 8738 11 at at IN cord-015021-pol2qm74 8738 12 an an DT cord-015021-pol2qm74 8738 13 optimum optimum JJ cord-015021-pol2qm74 8738 14 fixed fix VBN cord-015021-pol2qm74 8738 15 rate rate NN cord-015021-pol2qm74 8738 16 and and CC cord-015021-pol2qm74 8738 17 could could MD cord-015021-pol2qm74 8738 18 only only RB cord-015021-pol2qm74 8738 19 be be VB cord-015021-pol2qm74 8738 20 delayed delay VBN cord-015021-pol2qm74 8738 21 . . . cord-015021-pol2qm74 8739 1 The the DT cord-015021-pol2qm74 8739 2 recent recent JJ cord-015021-pol2qm74 8739 3 explosion explosion NN cord-015021-pol2qm74 8739 4 in in IN cord-015021-pol2qm74 8739 5 molecular molecular JJ cord-015021-pol2qm74 8739 6 biology biology NN cord-015021-pol2qm74 8739 7 and and CC cord-015021-pol2qm74 8739 8 recombinant recombinant JJ cord-015021-pol2qm74 8739 9 gene gene NN cord-015021-pol2qm74 8739 10 techniques technique NNS cord-015021-pol2qm74 8739 11 have have VBP cord-015021-pol2qm74 8739 12 produced produce VBN cord-015021-pol2qm74 8739 13 information information NN cord-015021-pol2qm74 8739 14 on on IN cord-015021-pol2qm74 8739 15 the the DT cord-015021-pol2qm74 8739 16 biological biological JJ cord-015021-pol2qm74 8739 17 activity activity NN cord-015021-pol2qm74 8739 18 of of IN cord-015021-pol2qm74 8739 19 compounds compound NNS cord-015021-pol2qm74 8739 20 previously previously RB cord-015021-pol2qm74 8739 21 believed believe VBD cord-015021-pol2qm74 8739 22 to to TO cord-015021-pol2qm74 8739 23 be be VB cord-015021-pol2qm74 8739 24 biologically biologically RB cord-015021-pol2qm74 8739 25 inert inert JJ cord-015021-pol2qm74 8739 26 . . . cord-015021-pol2qm74 8740 1 Many many JJ cord-015021-pol2qm74 8740 2 current current JJ cord-015021-pol2qm74 8740 3 attempts attempt NNS cord-015021-pol2qm74 8740 4 to to TO cord-015021-pol2qm74 8740 5 modulate modulate VB cord-015021-pol2qm74 8740 6 the the DT cord-015021-pol2qm74 8740 7 rate rate NN cord-015021-pol2qm74 8740 8 of of IN cord-015021-pol2qm74 8740 9 wound wound NN cord-015021-pol2qm74 8740 10 healing healing NN cord-015021-pol2qm74 8740 11 center center NN cord-015021-pol2qm74 8740 12 on on IN cord-015021-pol2qm74 8740 13 the the DT cord-015021-pol2qm74 8740 14 topical topical JJ cord-015021-pol2qm74 8740 15 application application NN cord-015021-pol2qm74 8740 16 of of IN cord-015021-pol2qm74 8740 17 various various JJ cord-015021-pol2qm74 8740 18 growth growth NN cord-015021-pol2qm74 8740 19 factors factor NNS cord-015021-pol2qm74 8740 20 produced produce VBN cord-015021-pol2qm74 8740 21 by by IN cord-015021-pol2qm74 8740 22 integumentary integumentary JJ cord-015021-pol2qm74 8740 23 cells cell NNS cord-015021-pol2qm74 8740 24 or or CC cord-015021-pol2qm74 8740 25 agents agent NNS cord-015021-pol2qm74 8740 26 designed design VBN cord-015021-pol2qm74 8740 27 to to TO cord-015021-pol2qm74 8740 28 modulate modulate VB cord-015021-pol2qm74 8740 29 growth growth NN cord-015021-pol2qm74 8740 30 factor factor NN cord-015021-pol2qm74 8740 31 expression expression NN cord-015021-pol2qm74 8740 32 or or CC cord-015021-pol2qm74 8740 33 response response NN cord-015021-pol2qm74 8740 34 . . . cord-015021-pol2qm74 8741 1 Epidermal epidermal JJ cord-015021-pol2qm74 8741 2 growth growth NN cord-015021-pol2qm74 8741 3 factor factor NN cord-015021-pol2qm74 8741 4 ( ( -LRB- cord-015021-pol2qm74 8741 5 EGF EGF NNP cord-015021-pol2qm74 8741 6 ) ) -RRB- cord-015021-pol2qm74 8741 7 , , , cord-015021-pol2qm74 8741 8 plateiet plateiet NNP cord-015021-pol2qm74 8741 9 derived derive VBD cord-015021-pol2qm74 8741 10 growth growth NN cord-015021-pol2qm74 8741 11 factor factor NN cord-015021-pol2qm74 8741 12 ( ( -LRB- cord-015021-pol2qm74 8741 13 PDGF PDGF NNP cord-015021-pol2qm74 8741 14 ) ) -RRB- cord-015021-pol2qm74 8741 15 , , , cord-015021-pol2qm74 8741 16 transforming transform VBG cord-015021-pol2qm74 8741 17 growth growth NN cord-015021-pol2qm74 8741 18 factor factor NN cord-015021-pol2qm74 8741 19 ( ( -LRB- cord-015021-pol2qm74 8741 20 TGF TGF NNP cord-015021-pol2qm74 8741 21 ) ) -RRB- cord-015021-pol2qm74 8741 22 and and CC cord-015021-pol2qm74 8741 23 fibroblast fibroblast NN cord-015021-pol2qm74 8741 24 growth growth NN cord-015021-pol2qm74 8741 25 factor factor NN cord-015021-pol2qm74 8741 26 ( ( -LRB- cord-015021-pol2qm74 8741 27 FGF FGF NNP cord-015021-pol2qm74 8741 28 ) ) -RRB- cord-015021-pol2qm74 8741 29 have have VBP cord-015021-pol2qm74 8741 30 been be VBN cord-015021-pol2qm74 8741 31 demonstrated demonstrate VBN cord-015021-pol2qm74 8741 32 , , , cord-015021-pol2qm74 8741 33 both both DT cord-015021-pol2qm74 8741 34 in in IN cord-015021-pol2qm74 8741 35 vitro vitro FW cord-015021-pol2qm74 8741 36 and and CC cord-015021-pol2qm74 8741 37 in in IN cord-015021-pol2qm74 8741 38 vivo vivo NN cord-015021-pol2qm74 8741 39 , , , cord-015021-pol2qm74 8741 40 to to TO cord-015021-pol2qm74 8741 41 stimulate stimulate VB cord-015021-pol2qm74 8741 42 the the DT cord-015021-pol2qm74 8741 43 proliferation proliferation NN cord-015021-pol2qm74 8741 44 and and CC cord-015021-pol2qm74 8741 45 diferentiation diferentiation NN cord-015021-pol2qm74 8741 46 of of IN cord-015021-pol2qm74 8741 47 their -PRON- PRP$ cord-015021-pol2qm74 8741 48 designated designate VBN cord-015021-pol2qm74 8741 49 cells cell NNS cord-015021-pol2qm74 8741 50 types type NNS cord-015021-pol2qm74 8741 51 . . . cord-015021-pol2qm74 8742 1 EGF EGF NNP cord-015021-pol2qm74 8742 2 and and CC cord-015021-pol2qm74 8742 3 PDGF PDGF NNP cord-015021-pol2qm74 8742 4 have have VBP cord-015021-pol2qm74 8742 5 been be VBN cord-015021-pol2qm74 8742 6 clearly clearly RB cord-015021-pol2qm74 8742 7 demonstraled demonstrale VBN cord-015021-pol2qm74 8742 8 to to TO cord-015021-pol2qm74 8742 9 increase increase VB cord-015021-pol2qm74 8742 10 the the DT cord-015021-pol2qm74 8742 11 rate rate NN cord-015021-pol2qm74 8742 12 of of IN cord-015021-pol2qm74 8742 13 wound wound NN cord-015021-pol2qm74 8742 14 closure closure NN cord-015021-pol2qm74 8742 15 in in IN cord-015021-pol2qm74 8742 16 partial partial JJ cord-015021-pol2qm74 8742 17 and and CC cord-015021-pol2qm74 8742 18 full full JJ cord-015021-pol2qm74 8742 19 thickness thickness NN cord-015021-pol2qm74 8742 20 wounds wound NNS cord-015021-pol2qm74 8742 21 . . . cord-015021-pol2qm74 8743 1 PDGF PDGF NNP cord-015021-pol2qm74 8743 2 also also RB cord-015021-pol2qm74 8743 3 has have VBZ cord-015021-pol2qm74 8743 4 demonstrated demonstrate VBN cord-015021-pol2qm74 8743 5 efficacy efficacy NN cord-015021-pol2qm74 8743 6 in in IN cord-015021-pol2qm74 8743 7 the the DT cord-015021-pol2qm74 8743 8 closure closure NN cord-015021-pol2qm74 8743 9 of of IN cord-015021-pol2qm74 8743 10 recalcitrant recalcitrant JJ cord-015021-pol2qm74 8743 11 pressure pressure NN cord-015021-pol2qm74 8743 12 sores sore NNS cord-015021-pol2qm74 8743 13 , , , cord-015021-pol2qm74 8743 14 whereas whereas IN cord-015021-pol2qm74 8743 15 TGF TGF NNP cord-015021-pol2qm74 8743 16 increases increase VBZ cord-015021-pol2qm74 8743 17 the the DT cord-015021-pol2qm74 8743 18 tensile tensile JJ cord-015021-pol2qm74 8743 19 strength strength NN cord-015021-pol2qm74 8743 20 of of IN cord-015021-pol2qm74 8743 21 incisiona incisiona NNP cord-015021-pol2qm74 8743 22 [ [ -LRB- cord-015021-pol2qm74 8743 23 wounds wound NNS cord-015021-pol2qm74 8743 24 and and CC cord-015021-pol2qm74 8743 25 FGF FGF NNP cord-015021-pol2qm74 8743 26 stimulates stimulate VBZ cord-015021-pol2qm74 8743 27 angiogenesis angiogenesis NN cord-015021-pol2qm74 8743 28 . . . cord-015021-pol2qm74 8744 1 It -PRON- PRP cord-015021-pol2qm74 8744 2 appears appear VBZ cord-015021-pol2qm74 8744 3 that that IN cord-015021-pol2qm74 8744 4 epidermal epidermal JJ cord-015021-pol2qm74 8744 5 keratinocyte keratinocyte JJ cord-015021-pol2qm74 8744 6 migration migration NN cord-015021-pol2qm74 8744 7 during during IN cord-015021-pol2qm74 8744 8 wound wound NN cord-015021-pol2qm74 8744 9 healing healing NN cord-015021-pol2qm74 8744 10 depends depend VBZ cord-015021-pol2qm74 8744 11 on on IN cord-015021-pol2qm74 8744 12 integrin integrin NN cord-015021-pol2qm74 8744 13 - - HYPH cord-015021-pol2qm74 8744 14 mediated mediate VBN cord-015021-pol2qm74 8744 15 interactions interaction NNS cord-015021-pol2qm74 8744 16 with with IN cord-015021-pol2qm74 8744 17 compounds compound NNS cord-015021-pol2qm74 8744 18 and and CC cord-015021-pol2qm74 8744 19 ceils ceils NNP cord-015021-pol2qm74 8744 20 extracellular extracellular JJ cord-015021-pol2qm74 8744 21 matrix matrix NN cord-015021-pol2qm74 8744 22 . . . cord-015021-pol2qm74 8745 1 Additionally additionally RB cord-015021-pol2qm74 8745 2 , , , cord-015021-pol2qm74 8745 3 the the DT cord-015021-pol2qm74 8745 4 activities activity NNS cord-015021-pol2qm74 8745 5 of of IN cord-015021-pol2qm74 8745 6 extracellular extracellular JJ cord-015021-pol2qm74 8745 7 glycoproteins glycoprotein NNS cord-015021-pol2qm74 8745 8 such such JJ cord-015021-pol2qm74 8745 9 as as IN cord-015021-pol2qm74 8745 10 fibronectin fibronectin NN cord-015021-pol2qm74 8745 11 , , , cord-015021-pol2qm74 8745 12 fibrinogen fibrinogen NN cord-015021-pol2qm74 8745 13 , , , cord-015021-pol2qm74 8745 14 laminin laminin NN cord-015021-pol2qm74 8745 15 and and CC cord-015021-pol2qm74 8745 16 thrombospondin thrombospondin NNP cord-015021-pol2qm74 8745 17 are be VBP cord-015021-pol2qm74 8745 18 coordinated coordinate VBN cord-015021-pol2qm74 8745 19 by by IN cord-015021-pol2qm74 8745 20 multiple multiple JJ cord-015021-pol2qm74 8745 21 integrins integrin NNS cord-015021-pol2qm74 8745 22 with with IN cord-015021-pol2qm74 8745 23 specific specific JJ cord-015021-pol2qm74 8745 24 distributions distribution NNS cord-015021-pol2qm74 8745 25 and and CC cord-015021-pol2qm74 8745 26 binding bind VBG cord-015021-pol2qm74 8745 27 affinities affinity NNS cord-015021-pol2qm74 8745 28 . . . cord-015021-pol2qm74 8746 1 Currently currently RB cord-015021-pol2qm74 8746 2 , , , cord-015021-pol2qm74 8746 3 agents agent NNS cord-015021-pol2qm74 8746 4 which which WDT cord-015021-pol2qm74 8746 5 incorporate incorporate VBP cord-015021-pol2qm74 8746 6 specific specific JJ cord-015021-pol2qm74 8746 7 protein protein NN cord-015021-pol2qm74 8746 8 sequences sequence NNS cord-015021-pol2qm74 8746 9 essential essential JJ cord-015021-pol2qm74 8746 10 for for IN cord-015021-pol2qm74 8746 11 the the DT cord-015021-pol2qm74 8746 12 interaction interaction NN cord-015021-pol2qm74 8746 13 of of IN cord-015021-pol2qm74 8746 14 the the DT cord-015021-pol2qm74 8746 15 glycoproteins glycoprotein NNS cord-015021-pol2qm74 8746 16 with with IN cord-015021-pol2qm74 8746 17 the the DT cord-015021-pol2qm74 8746 18 cells cell NNS cord-015021-pol2qm74 8746 19 of of IN cord-015021-pol2qm74 8746 20 the the DT cord-015021-pol2qm74 8746 21 extracellular extracellular JJ cord-015021-pol2qm74 8746 22 matrix matrix NN cord-015021-pol2qm74 8746 23 are be VBP cord-015021-pol2qm74 8746 24 being be VBG cord-015021-pol2qm74 8746 25 investigated investigate VBN cord-015021-pol2qm74 8746 26 . . . cord-015021-pol2qm74 8747 1 It -PRON- PRP cord-015021-pol2qm74 8747 2 is be VBZ cord-015021-pol2qm74 8747 3 has have VBZ cord-015021-pol2qm74 8747 4 been be VBN cord-015021-pol2qm74 8747 5 clearly clearly RB cord-015021-pol2qm74 8747 6 established establish VBN cord-015021-pol2qm74 8747 7 that that IN cord-015021-pol2qm74 8747 8 the the DT cord-015021-pol2qm74 8747 9 rate rate NN cord-015021-pol2qm74 8747 10 and and CC cord-015021-pol2qm74 8747 11 nature nature NN cord-015021-pol2qm74 8747 12 of of IN cord-015021-pol2qm74 8747 13 wound wound NN cord-015021-pol2qm74 8747 14 healing healing NN cord-015021-pol2qm74 8747 15 can can MD cord-015021-pol2qm74 8747 16 be be VB cord-015021-pol2qm74 8747 17 influenced influence VBN cord-015021-pol2qm74 8747 18 by by IN cord-015021-pol2qm74 8747 19 the the DT cord-015021-pol2qm74 8747 20 application application NN cord-015021-pol2qm74 8747 21 of of IN cord-015021-pol2qm74 8747 22 various various JJ cord-015021-pol2qm74 8747 23 agents agent NNS cord-015021-pol2qm74 8747 24 and and CC cord-015021-pol2qm74 8747 25 that that IN cord-015021-pol2qm74 8747 26 sufficient sufficient JJ cord-015021-pol2qm74 8747 27 quantities quantity NNS cord-015021-pol2qm74 8747 28 of of IN cord-015021-pol2qm74 8747 29 these these DT cord-015021-pol2qm74 8747 30 agents agent NNS cord-015021-pol2qm74 8747 31 can can MD cord-015021-pol2qm74 8747 32 be be VB cord-015021-pol2qm74 8747 33 manufactured manufacture VBN cord-015021-pol2qm74 8747 34 . . . cord-015021-pol2qm74 8748 1 The the DT cord-015021-pol2qm74 8748 2 future future JJ cord-015021-pol2qm74 8748 3 challenge challenge NN cord-015021-pol2qm74 8748 4 is be VBZ cord-015021-pol2qm74 8748 5 to to TO cord-015021-pol2qm74 8748 6 develop develop VB cord-015021-pol2qm74 8748 7 techniques technique NNS cord-015021-pol2qm74 8748 8 to to IN cord-015021-pol2qm74 8748 9 Now now RB cord-015021-pol2qm74 8748 10 the the DT cord-015021-pol2qm74 8748 11 objective objective JJ cord-015021-pol2qm74 8748 12 evaluation evaluation NN cord-015021-pol2qm74 8748 13 of of IN cord-015021-pol2qm74 8748 14 the the DT cord-015021-pol2qm74 8748 15 clinical clinical JJ cord-015021-pol2qm74 8748 16 efficacy efficacy NN cord-015021-pol2qm74 8748 17 of of IN cord-015021-pol2qm74 8748 18 these these DT cord-015021-pol2qm74 8748 19 various various JJ cord-015021-pol2qm74 8748 20 agents agent NNS cord-015021-pol2qm74 8748 21 and and CC cord-015021-pol2qm74 8748 22 to to TO cord-015021-pol2qm74 8748 23 employ employ VB cord-015021-pol2qm74 8748 24 the the DT cord-015021-pol2qm74 8748 25 appropriate appropriate JJ cord-015021-pol2qm74 8748 26 agents agent NNS cord-015021-pol2qm74 8748 27 in in IN cord-015021-pol2qm74 8748 28 a a DT cord-015021-pol2qm74 8748 29 cost cost NN cord-015021-pol2qm74 8748 30 - - HYPH cord-015021-pol2qm74 8748 31 effective effective JJ cord-015021-pol2qm74 8748 32 manner manner NN cord-015021-pol2qm74 8748 33 . . . cord-015021-pol2qm74 8748 34 _SP cord-015021-pol2qm74 8749 1 transplantation transplantation NN cord-015021-pol2qm74 8749 2 ; ; : cord-015021-pol2qm74 8749 3 and and CC cord-015021-pol2qm74 8749 4 4 4 LS cord-015021-pol2qm74 8749 5 ) ) -RRB- cord-015021-pol2qm74 8749 6 the the DT cord-015021-pol2qm74 8749 7 immune immune JJ cord-015021-pol2qm74 8749 8 status status NN cord-015021-pol2qm74 8749 9 / / SYM cord-015021-pol2qm74 8749 10 manipulation manipulation NN cord-015021-pol2qm74 8749 11 of of IN cord-015021-pol2qm74 8749 12 the the DT cord-015021-pol2qm74 8749 13 host host NN cord-015021-pol2qm74 8749 14 . . . cord-015021-pol2qm74 8750 1 Multiple multiple JJ cord-015021-pol2qm74 8750 2 interactive interactive JJ cord-015021-pol2qm74 8750 3 variables variable NNS cord-015021-pol2qm74 8750 4 will will MD cord-015021-pol2qm74 8750 5 determine determine VB cord-015021-pol2qm74 8750 6 the the DT cord-015021-pol2qm74 8750 7 effect effect NN cord-015021-pol2qm74 8750 8 of of IN cord-015021-pol2qm74 8750 9 employing employ VBG cord-015021-pol2qm74 8750 10 allogeneic allogeneic NN cord-015021-pol2qm74 8750 11 cells cell NNS cord-015021-pol2qm74 8750 12 and and CC cord-015021-pol2qm74 8750 13 tissue tissue NN cord-015021-pol2qm74 8750 14 in in IN cord-015021-pol2qm74 8750 15 wound wound NN cord-015021-pol2qm74 8750 16 coverage coverage NN cord-015021-pol2qm74 8750 17 design design NN cord-015021-pol2qm74 8750 18 and and CC cord-015021-pol2qm74 8750 19 a a DT cord-015021-pol2qm74 8750 20 batter batter NN cord-015021-pol2qm74 8750 21 understanding understanding NN cord-015021-pol2qm74 8750 22 of of IN cord-015021-pol2qm74 8750 23 the the DT cord-015021-pol2qm74 8750 24 dynamics dynamic NNS cord-015021-pol2qm74 8750 25 of of IN cord-015021-pol2qm74 8750 26 the the DT cord-015021-pol2qm74 8750 27 wound wound NN cord-015021-pol2qm74 8750 28 - - HYPH cord-015021-pol2qm74 8750 29 graft graft NN cord-015021-pol2qm74 8750 30 microenvironment microenvironment NN cord-015021-pol2qm74 8750 31 will will MD cord-015021-pol2qm74 8750 32 facilitate facilitate VB cord-015021-pol2qm74 8750 33 the the DT cord-015021-pol2qm74 8750 34 dove dove NN cord-015021-pol2qm74 8750 35 opment opment NN cord-015021-pol2qm74 8750 36 of of IN cord-015021-pol2qm74 8750 37 clinicaUy clinicauy JJ cord-015021-pol2qm74 8750 38 beneficial beneficial JJ cord-015021-pol2qm74 8750 39 graft graft NN cord-015021-pol2qm74 8750 40 composites composite NNS cord-015021-pol2qm74 8750 41 . . . cord-015021-pol2qm74 8751 1 Cadaver cadaver NN cord-015021-pol2qm74 8751 2 allograft allograft NN cord-015021-pol2qm74 8751 3 skin skin NN cord-015021-pol2qm74 8751 4 ( ( -LRB- cord-015021-pol2qm74 8751 5 CAS CAS NNP cord-015021-pol2qm74 8751 6 ) ) -RRB- cord-015021-pol2qm74 8751 7 is be VBZ cord-015021-pol2qm74 8751 8 the the DT cord-015021-pol2qm74 8751 9 " " `` cord-015021-pol2qm74 8751 10 gold gold NN cord-015021-pol2qm74 8751 11 standard standard NN cord-015021-pol2qm74 8751 12 " " '' cord-015021-pol2qm74 8751 13 for for IN cord-015021-pol2qm74 8751 14 wound wound JJ cord-015021-pol2qm74 8751 15 coverage coverage NN cord-015021-pol2qm74 8751 16 , , , cord-015021-pol2qm74 8751 17 but but CC cord-015021-pol2qm74 8751 18 has have VBZ cord-015021-pol2qm74 8751 19 limitations limitation NNS cord-015021-pol2qm74 8751 20 including include VBG cord-015021-pol2qm74 8751 21 varied varied JJ cord-015021-pol2qm74 8751 22 availability availability NN cord-015021-pol2qm74 8751 23 & & CC cord-015021-pol2qm74 8751 24 quality quality NN cord-015021-pol2qm74 8751 25 , , , cord-015021-pol2qm74 8751 26 immunogenicity immunogenicity IN cord-015021-pol2qm74 8751 27 leading lead VBG cord-015021-pol2qm74 8751 28 to to IN cord-015021-pol2qm74 8751 29 rejection rejection NN cord-015021-pol2qm74 8751 30 , , , cord-015021-pol2qm74 8751 31 & & CC cord-015021-pol2qm74 8751 32 potential potential NN cord-015021-pol2qm74 8751 33 for for IN cord-015021-pol2qm74 8751 34 disease disease NN cord-015021-pol2qm74 8751 35 transmission transmission NN cord-015021-pol2qm74 8751 36 . . . cord-015021-pol2qm74 8752 1 Our -PRON- PRP$ cord-015021-pol2qm74 8752 2 development development NN cord-015021-pol2qm74 8752 3 of of IN cord-015021-pol2qm74 8752 4 a a DT cord-015021-pol2qm74 8752 5 temporary temporary JJ cord-015021-pol2qm74 8752 6 living living NN cord-015021-pol2qm74 8752 7 skin skin NN cord-015021-pol2qm74 8752 8 replacement replacement NN cord-015021-pol2qm74 8752 9 ( ( -LRB- cord-015021-pol2qm74 8752 10 TLSR TLSR NNP cord-015021-pol2qm74 8752 11 ) ) -RRB- cord-015021-pol2qm74 8752 12 addresses address VBZ cord-015021-pol2qm74 8752 13 these these DT cord-015021-pol2qm74 8752 14 issues issue NNS cord-015021-pol2qm74 8752 15 ; ; : cord-015021-pol2qm74 8752 16 the the DT cord-015021-pol2qm74 8752 17 TLSR TLSR NNP cord-015021-pol2qm74 8752 18 consists consist VBZ cord-015021-pol2qm74 8752 19 of of IN cord-015021-pol2qm74 8752 20 highly highly RB cord-015021-pol2qm74 8752 21 screened screen VBN cord-015021-pol2qm74 8752 22 human human JJ cord-015021-pol2qm74 8752 23 neonatal neonatal JJ cord-015021-pol2qm74 8752 24 fibroblasts fibroblast NNS cord-015021-pol2qm74 8752 25 ( ( -LRB- cord-015021-pol2qm74 8752 26 HF HF NNP cord-015021-pol2qm74 8752 27 ) ) -RRB- cord-015021-pol2qm74 8752 28 cultured culture VBN cord-015021-pol2qm74 8752 29 in in IN cord-015021-pol2qm74 8752 30 Biobrane Biobrane NNP cord-015021-pol2qm74 8752 31 a a NNP cord-015021-pol2qm74 8752 32 , , , cord-015021-pol2qm74 8752 33 a a DT cord-015021-pol2qm74 8752 34 bilayer bilayer NN cord-015021-pol2qm74 8752 35 dressing dressing NN cord-015021-pol2qm74 8752 36 consisting consist VBG cord-015021-pol2qm74 8752 37 of of IN cord-015021-pol2qm74 8752 38 nylon nylon NN cord-015021-pol2qm74 8752 39 mesh mesh NN cord-015021-pol2qm74 8752 40 laminated laminate VBN cord-015021-pol2qm74 8752 41 to to IN cord-015021-pol2qm74 8752 42 a a DT cord-015021-pol2qm74 8752 43 thin thin JJ cord-015021-pol2qm74 8752 44 silicone silicone NN cord-015021-pol2qm74 8752 45 membrane membrane NN cord-015021-pol2qm74 8752 46 which which WDT cord-015021-pol2qm74 8752 47 controls control VBZ cord-015021-pol2qm74 8752 48 water water NN cord-015021-pol2qm74 8752 49 - - HYPH cord-015021-pol2qm74 8752 50 vapor vapor NN cord-015021-pol2qm74 8752 51 transmission transmission NN cord-015021-pol2qm74 8752 52 . . . cord-015021-pol2qm74 8753 1 Studies study NNS cord-015021-pol2qm74 8753 2 in in IN cord-015021-pol2qm74 8753 3 our -PRON- PRP$ cord-015021-pol2qm74 8753 4 lab lab NN cord-015021-pol2qm74 8753 5 indicated indicate VBD cord-015021-pol2qm74 8753 6 that that IN cord-015021-pol2qm74 8753 7 " " `` cord-015021-pol2qm74 8753 8 fresW fresW NNP cord-015021-pol2qm74 8753 9 ~ ~ NFP cord-015021-pol2qm74 8753 10 TLSR TLSR NNP cord-015021-pol2qm74 8753 11 grafts graft NNS cord-015021-pol2qm74 8753 12 reproducibly reproducibly RB cord-015021-pol2qm74 8753 13 close close VBP cord-015021-pol2qm74 8753 14 full full JJ cord-015021-pol2qm74 8753 15 - - HYPH cord-015021-pol2qm74 8753 16 thickness thickness NN cord-015021-pol2qm74 8753 17 wounds wound NNS cord-015021-pol2qm74 8753 18 in in IN cord-015021-pol2qm74 8753 19 mice mouse NNS cord-015021-pol2qm74 8753 20 & & CC cord-015021-pol2qm74 8753 21 perform perform VB cord-015021-pol2qm74 8753 22 better well JJR cord-015021-pol2qm74 8753 23 than than IN cord-015021-pol2qm74 8753 24 BB BB NNP cord-015021-pol2qm74 8753 25 controls control NNS cord-015021-pol2qm74 8753 26 . . . cord-015021-pol2qm74 8754 1 We -PRON- PRP cord-015021-pol2qm74 8754 2 studied study VBD cord-015021-pol2qm74 8754 3 wound wound JJ cord-015021-pol2qm74 8754 4 adherence adherence NN cord-015021-pol2qm74 8754 5 & & CC cord-015021-pol2qm74 8754 6 structural structural JJ cord-015021-pol2qm74 8754 7 / / SYM cord-015021-pol2qm74 8754 8 molecular molecular JJ cord-015021-pol2qm74 8754 9 properties property NNS cord-015021-pol2qm74 8754 10 of of IN cord-015021-pol2qm74 8754 11 fresh fresh JJ cord-015021-pol2qm74 8754 12 & & CC cord-015021-pol2qm74 8754 13 cryopreserved cryopreserved JJ cord-015021-pol2qm74 8754 14 ( ( -LRB- cord-015021-pol2qm74 8754 15 CRYO CRYO NNP cord-015021-pol2qm74 8754 16 ) ) -RRB- cord-015021-pol2qm74 8755 1 TLSR TLSR NNP cord-015021-pol2qm74 8755 2 . . . cord-015021-pol2qm74 8756 1 METHODS methods NN cord-015021-pol2qm74 8756 2 : : : cord-015021-pol2qm74 8757 1 TLSRs tlsr NNS cord-015021-pol2qm74 8757 2 were be VBD cord-015021-pol2qm74 8757 3 prepared prepare VBN cord-015021-pol2qm74 8757 4 by by IN cord-015021-pol2qm74 8757 5 seeding seed VBG cord-015021-pol2qm74 8757 6 4000 4000 CD cord-015021-pol2qm74 8757 7 / / SYM cord-015021-pol2qm74 8757 8 co co NN cord-015021-pol2qm74 8757 9 2 2 CD cord-015021-pol2qm74 8757 10 HF HF NNP cord-015021-pol2qm74 8757 11 in in IN cord-015021-pol2qm74 8757 12 BB bb NN cord-015021-pol2qm74 8757 13 nylon nylon NN cord-015021-pol2qm74 8757 14 mesh mesh NN cord-015021-pol2qm74 8757 15 in in IN cord-015021-pol2qm74 8757 16 DMEM DMEM NNP cord-015021-pol2qm74 8757 17 . . . cord-015021-pol2qm74 8758 1 HF HF NNP cord-015021-pol2qm74 8758 2 quickly quickly RB cord-015021-pol2qm74 8758 3 attached attach VBD cord-015021-pol2qm74 8758 4 to to IN cord-015021-pol2qm74 8758 5 the the DT cord-015021-pol2qm74 8758 6 nylon nylon NN cord-015021-pol2qm74 8758 7 mesh mesh NN cord-015021-pol2qm74 8758 8 & & CC cord-015021-pol2qm74 8758 9 were be VBD cord-015021-pol2qm74 8758 10 allowed allow VBN cord-015021-pol2qm74 8758 11 to to TO cord-015021-pol2qm74 8758 12 proliferate proliferate VB cord-015021-pol2qm74 8758 13 3 3 CD cord-015021-pol2qm74 8758 14 - - SYM cord-015021-pol2qm74 8758 15 6 6 CD cord-015021-pol2qm74 8758 16 wks wks NN cord-015021-pol2qm74 8758 17 . . . cord-015021-pol2qm74 8759 1 Fibroblast fibroblast JJ cord-015021-pol2qm74 8759 2 mitochondrial mitochondrial NN cord-015021-pol2qm74 8759 3 activity activity NN cord-015021-pol2qm74 8759 4 was be VBD cord-015021-pol2qm74 8759 5 assayed assay VBN cord-015021-pol2qm74 8759 6 by by IN cord-015021-pol2qm74 8759 7 MTT MTT NNP cord-015021-pol2qm74 8759 8 assay assay NN cord-015021-pol2qm74 8759 9 . . . cord-015021-pol2qm74 8760 1 Matrix matrix NN cord-015021-pol2qm74 8760 2 proteins protein NNS cord-015021-pol2qm74 8760 3 were be VBD cord-015021-pol2qm74 8760 4 identified identify VBN cord-015021-pol2qm74 8760 5 by by IN cord-015021-pol2qm74 8760 6 immunostaining immunostaine VBG cord-015021-pol2qm74 8760 7 , , , cord-015021-pol2qm74 8760 8 mRNAs mRNAs NNPS cord-015021-pol2qm74 8760 9 for for IN cord-015021-pol2qm74 8760 10 specific specific JJ cord-015021-pol2qm74 8760 11 growth growth NN cord-015021-pol2qm74 8760 12 factors factor NNS cord-015021-pol2qm74 8760 13 were be VBD cord-015021-pol2qm74 8760 14 identified identify VBN cord-015021-pol2qm74 8760 15 by by IN cord-015021-pol2qm74 8760 16 reverse reverse JJ cord-015021-pol2qm74 8760 17 - - HYPH cord-015021-pol2qm74 8760 18 transcription transcription NN cord-015021-pol2qm74 8760 19 polymerase polymerase NN cord-015021-pol2qm74 8760 20 chain chain NN cord-015021-pol2qm74 8760 21 reaction reaction NN cord-015021-pol2qm74 8760 22 amplification amplification NN cord-015021-pol2qm74 8760 23 , , , cord-015021-pol2qm74 8760 24 & & CC cord-015021-pol2qm74 8760 25 quantitated quantitate VBN cord-015021-pol2qm74 8760 26 by by IN cord-015021-pol2qm74 8760 27 gel gel NN cord-015021-pol2qm74 8760 28 scans scan NNS cord-015021-pol2qm74 8760 29 . . . cord-015021-pol2qm74 8761 1 BB BB NNP cord-015021-pol2qm74 8761 2 structure structure NN cord-015021-pol2qm74 8761 3 was be VBD cord-015021-pol2qm74 8761 4 studied study VBN cord-015021-pol2qm74 8761 5 by by IN cord-015021-pol2qm74 8761 6 scanning scan VBG cord-015021-pol2qm74 8761 7 electron electron NN cord-015021-pol2qm74 8761 8 microscopy microscopy NNP cord-015021-pol2qm74 8761 9 & & CC cord-015021-pol2qm74 8761 10 stretching stretch VBG cord-015021-pol2qm74 8761 11 measurements measurement NNS cord-015021-pol2qm74 8761 12 pro pro JJ cord-015021-pol2qm74 8761 13 / / SYM cord-015021-pol2qm74 8761 14 post post JJ cord-015021-pol2qm74 8761 15 CRYO CRYO NNP cord-015021-pol2qm74 8761 16 . . . cord-015021-pol2qm74 8762 1 80 80 CD cord-015021-pol2qm74 8762 2 grafts graft NNS cord-015021-pol2qm74 8762 3 were be VBD cord-015021-pol2qm74 8762 4 CRYO'd CRYO'd NNS cord-015021-pol2qm74 8762 5 in in IN cord-015021-pol2qm74 8762 6 10 10 CD cord-015021-pol2qm74 8762 7 % % NN cord-015021-pol2qm74 8762 8 DMSO DMSO NNP cord-015021-pol2qm74 8762 9 , , , cord-015021-pol2qm74 8762 10 quick quick RB cord-015021-pol2qm74 8762 11 - - HYPH cord-015021-pol2qm74 8762 12 thawed thaw VBN cord-015021-pol2qm74 8762 13 & & CC cord-015021-pol2qm74 8762 14 sutured suture VBN cord-015021-pol2qm74 8762 15 onto onto IN cord-015021-pol2qm74 8762 16 2X2 2x2 CD cord-015021-pol2qm74 8762 17 cm cm NNS cord-015021-pol2qm74 8762 18 excised excise VBN cord-015021-pol2qm74 8762 19 full full JJ cord-015021-pol2qm74 8762 20 - - HYPH cord-015021-pol2qm74 8762 21 thickness thickness NN cord-015021-pol2qm74 8762 22 dorsal dorsal JJ cord-015021-pol2qm74 8762 23 wounds wound NNS cord-015021-pol2qm74 8762 24 on on IN cord-015021-pol2qm74 8762 25 athymic athymic JJ cord-015021-pol2qm74 8762 26 mice mouse NNS cord-015021-pol2qm74 8762 27 . . . cord-015021-pol2qm74 8763 1 40 40 CD cord-015021-pol2qm74 8763 2 " " `` cord-015021-pol2qm74 8763 3 fresh fresh JJ cord-015021-pol2qm74 8763 4 " " '' cord-015021-pol2qm74 8763 5 grafts graft NNS cord-015021-pol2qm74 8763 6 were be VBD cord-015021-pol2qm74 8763 7 similarly similarly RB cord-015021-pol2qm74 8763 8 placed place VBN cord-015021-pol2qm74 8763 9 . . . cord-015021-pol2qm74 8764 1 Controls control NNS cord-015021-pol2qm74 8764 2 grafts graft NNS cord-015021-pol2qm74 8764 3 were be VBD cord-015021-pol2qm74 8764 4 CAS CAS NNP cord-015021-pol2qm74 8764 5 and and CC cord-015021-pol2qm74 8764 6 aeellular aeellular JJ cord-015021-pol2qm74 8764 7 BB BB NNP cord-015021-pol2qm74 8764 8 . . . cord-015021-pol2qm74 8765 1 Adherence adherence NN cord-015021-pol2qm74 8765 2 was be VBD cord-015021-pol2qm74 8765 3 quantitated quantitate VBN cord-015021-pol2qm74 8765 4 by by IN cord-015021-pol2qm74 8765 5 a a DT cord-015021-pol2qm74 8765 6 device device NN cord-015021-pol2qm74 8765 7 which which WDT cord-015021-pol2qm74 8765 8 peeled peel VBD cord-015021-pol2qm74 8765 9 grafts graft NNS cord-015021-pol2qm74 8765 10 from from IN cord-015021-pol2qm74 8765 11 wounds wound NNS cord-015021-pol2qm74 8765 12 at at IN cord-015021-pol2qm74 8765 13 intervals interval NNS cord-015021-pol2qm74 8765 14 following follow VBG cord-015021-pol2qm74 8765 15 placement placement NN cord-015021-pol2qm74 8765 16 , , , cord-015021-pol2qm74 8765 17 using use VBG cord-015021-pol2qm74 8765 18 a a DT cord-015021-pol2qm74 8765 19 serve serve JJ cord-015021-pol2qm74 8765 20 motor motor NN cord-015021-pol2qm74 8765 21 and and CC cord-015021-pol2qm74 8765 22 a a DT cord-015021-pol2qm74 8765 23 strain strain NN cord-015021-pol2qm74 8765 24 gauge gauge NN cord-015021-pol2qm74 8765 25 . . . cord-015021-pol2qm74 8766 1 RESULTS result NNS cord-015021-pol2qm74 8766 2 : : : cord-015021-pol2qm74 8767 1 PostCRYO PostCRYO NNP cord-015021-pol2qm74 8767 2 , , , cord-015021-pol2qm74 8767 3 storage storage NN cord-015021-pol2qm74 8767 4 and and CC cord-015021-pol2qm74 8767 5 subsequent subsequent JJ cord-015021-pol2qm74 8767 6 thawing thaw VBG cord-015021-pol2qm74 8767 7 tile tile NN cord-015021-pol2qm74 8767 8 TLSRs tlsr NNS cord-015021-pol2qm74 8767 9 maintained maintain VBD cord-015021-pol2qm74 8767 10 > > : cord-015021-pol2qm74 8767 11 60 60 CD cord-015021-pol2qm74 8767 12 % % NN cord-015021-pol2qm74 8767 13 cell cell NN cord-015021-pol2qm74 8767 14 viability viability NN cord-015021-pol2qm74 8767 15 by by IN cord-015021-pol2qm74 8767 16 the the DT cord-015021-pol2qm74 8767 17 MTT MTT NNP cord-015021-pol2qm74 8767 18 assay assay NN cord-015021-pol2qm74 8767 19 , , , cord-015021-pol2qm74 8767 20 indicating indicate VBG cord-015021-pol2qm74 8767 21 continued continue VBN cord-015021-pol2qm74 8767 22 mitochondrial mitochondrial JJ cord-015021-pol2qm74 8767 23 activity activity NN cord-015021-pol2qm74 8767 24 , , , cord-015021-pol2qm74 8767 25 and and CC cord-015021-pol2qm74 8767 26 BB BB NNP cord-015021-pol2qm74 8767 27 structure structure NN cord-015021-pol2qm74 8767 28 & & CC cord-015021-pol2qm74 8767 29 stretchability stretchability NN cord-015021-pol2qm74 8767 30 were be VBD cord-015021-pol2qm74 8767 31 maintained maintain VBN cord-015021-pol2qm74 8767 32 . . . cord-015021-pol2qm74 8768 1 Multiple multiple JJ cord-015021-pol2qm74 8768 2 matrix matrix NN cord-015021-pol2qm74 8768 3 proteins protein NNS cord-015021-pol2qm74 8768 4 secreted secrete VBN cord-015021-pol2qm74 8768 5 and and CC cord-015021-pol2qm74 8768 6 deposited deposit VBN cord-015021-pol2qm74 8768 7 in in IN cord-015021-pol2qm74 8768 8 the the DT cord-015021-pol2qm74 8768 9 BB bb NN cord-015021-pol2qm74 8768 10 nylon nylon NN cord-015021-pol2qm74 8768 11 mesh mesh NN cord-015021-pol2qm74 8768 12 ( ( -LRB- cord-015021-pol2qm74 8768 13 types type NNS cord-015021-pol2qm74 8768 14 l l NN cord-015021-pol2qm74 8768 15 / / SYM cord-015021-pol2qm74 8768 16 III iii CD cord-015021-pol2qm74 8768 17 collagen collagen NN cord-015021-pol2qm74 8768 18 , , , cord-015021-pol2qm74 8768 19 decorin decorin NNP cord-015021-pol2qm74 8768 20 , , , cord-015021-pol2qm74 8768 21 fibroneetin fibroneetin NNP cord-015021-pol2qm74 8768 22 ) ) -RRB- cord-015021-pol2qm74 8768 23 were be VBD cord-015021-pol2qm74 8768 24 identified identify VBN cord-015021-pol2qm74 8768 25 by by IN cord-015021-pol2qm74 8768 26 specific specific JJ cord-015021-pol2qm74 8768 27 immunostaining immunostaining NN cord-015021-pol2qm74 8768 28 . . . cord-015021-pol2qm74 8769 1 Growth growth NN cord-015021-pol2qm74 8769 2 factor factor NN cord-015021-pol2qm74 8769 3 mRNAs mrnas XX cord-015021-pol2qm74 8769 4 in in IN cord-015021-pol2qm74 8769 5 the the DT cord-015021-pol2qm74 8769 6 TLSRs tlsr NNS cord-015021-pol2qm74 8769 7 ( ( -LRB- cord-015021-pol2qm74 8769 8 aFGF afgf RB cord-015021-pol2qm74 8769 9 , , , cord-015021-pol2qm74 8769 10 bFGF bfgf NN cord-015021-pol2qm74 8769 11 , , , cord-015021-pol2qm74 8769 12 KGF KGF NNP cord-015021-pol2qm74 8769 13 , , , cord-015021-pol2qm74 8769 14 TGF~,p~ TGF~,p~ NNP cord-015021-pol2qm74 8769 15 , , , cord-015021-pol2qm74 8769 16 ) ) -RRB- cord-015021-pol2qm74 8769 17 were be VBD cord-015021-pol2qm74 8769 18 present present JJ cord-015021-pol2qm74 8769 19 in in IN cord-015021-pol2qm74 8769 20 10 10 CD cord-015021-pol2qm74 8769 21 - - SYM cord-015021-pol2qm74 8769 22 10,000X 10,000x CD cord-015021-pol2qm74 8769 23 higher high JJR cord-015021-pol2qm74 8769 24 levels level NNS cord-015021-pol2qm74 8769 25 in in IN cord-015021-pol2qm74 8769 26 fresh fresh JJ cord-015021-pol2qm74 8769 27 / / SYM cord-015021-pol2qm74 8769 28 CRYO CRYO NNP cord-015021-pol2qm74 8769 29 TLSRs tlsr NNS cord-015021-pol2qm74 8769 30 than than IN cord-015021-pol2qm74 8769 31 in in IN cord-015021-pol2qm74 8769 32 adult adult NN cord-015021-pol2qm74 8769 33 HCS HCS NNP cord-015021-pol2qm74 8769 34 . . . cord-015021-pol2qm74 8770 1 Grafts graft NNS cord-015021-pol2qm74 8770 2 adhered adhere VBD cord-015021-pol2qm74 8770 3 to to IN cord-015021-pol2qm74 8770 4 wounds wound NNS cord-015021-pol2qm74 8770 5 on on IN cord-015021-pol2qm74 8770 6 mice mouse NNS cord-015021-pol2qm74 8770 7 through through IN cord-015021-pol2qm74 8770 8 40 40 CD cord-015021-pol2qm74 8770 9 days day NNS cord-015021-pol2qm74 8770 10 of of IN cord-015021-pol2qm74 8770 11 followup followup NN cord-015021-pol2qm74 8770 12 . . . cord-015021-pol2qm74 8771 1 Histologic Histologic NNP cord-015021-pol2qm74 8771 2 exams exam NNS cord-015021-pol2qm74 8771 3 on on IN cord-015021-pol2qm74 8771 4 days day NNS cord-015021-pol2qm74 8771 5 6 6 CD cord-015021-pol2qm74 8771 6 - - SYM cord-015021-pol2qm74 8771 7 40 40 CD cord-015021-pol2qm74 8771 8 showed show VBD cord-015021-pol2qm74 8771 9 excellent excellent JJ cord-015021-pol2qm74 8771 10 vascular vascular JJ cord-015021-pol2qm74 8771 11 ingrowth ingrowth NN cord-015021-pol2qm74 8771 12 and and CC cord-015021-pol2qm74 8771 13 minimal minimal JJ cord-015021-pol2qm74 8771 14 inflammation inflammation NN cord-015021-pol2qm74 8771 15 . . . cord-015021-pol2qm74 8772 1 Adherence adherence NN cord-015021-pol2qm74 8772 2 of of IN cord-015021-pol2qm74 8772 3 TLSRs tlsr NNS cord-015021-pol2qm74 8772 4 to to IN cord-015021-pol2qm74 8772 5 wounds wound NNS cord-015021-pol2qm74 8772 6 was be VBD cord-015021-pol2qm74 8772 7 > > XX cord-015021-pol2qm74 8772 8 CAS CAS NNP cord-015021-pol2qm74 8772 9 adherence adherence NN cord-015021-pol2qm74 8772 10 . . . cord-015021-pol2qm74 8773 1 Burn burn VB cord-015021-pol2qm74 8773 2 wound wound JJ cord-015021-pol2qm74 8773 3 coverage coverage NN cord-015021-pol2qm74 8773 4 in in IN cord-015021-pol2qm74 8773 5 the the DT cord-015021-pol2qm74 8773 6 massively massively RB cord-015021-pol2qm74 8773 7 burned burn VBN cord-015021-pol2qm74 8773 8 patient patient NN cord-015021-pol2qm74 8773 9 remains remain VBZ cord-015021-pol2qm74 8773 10 a a DT cord-015021-pol2qm74 8773 11 difficult difficult JJ cord-015021-pol2qm74 8773 12 problem problem NN cord-015021-pol2qm74 8773 13 . . . cord-015021-pol2qm74 8774 1 Although although IN cord-015021-pol2qm74 8774 2 cultured cultured JJ cord-015021-pol2qm74 8774 3 keratinocytes keratinocyte NNS cord-015021-pol2qm74 8774 4 have have VBP cord-015021-pol2qm74 8774 5 been be VBN cord-015021-pol2qm74 8774 6 utilized utilize VBN cord-015021-pol2qm74 8774 7 for for IN cord-015021-pol2qm74 8774 8 burn burn NN cord-015021-pol2qm74 8774 9 wound wound NN cord-015021-pol2qm74 8774 10 coverage coverage NN cord-015021-pol2qm74 8774 11 , , , cord-015021-pol2qm74 8774 12 their -PRON- PRP$ cord-015021-pol2qm74 8774 13 impact impact NN cord-015021-pol2qm74 8774 14 on on IN cord-015021-pol2qm74 8774 15 the the DT cord-015021-pol2qm74 8774 16 patient patient NN cord-015021-pol2qm74 8774 17 with with IN cord-015021-pol2qm74 8774 18 burns burn NNS cord-015021-pol2qm74 8774 19 greater great JJR cord-015021-pol2qm74 8774 20 than than IN cord-015021-pol2qm74 8774 21 80 80 CD cord-015021-pol2qm74 8774 22 % % NN cord-015021-pol2qm74 8774 23 total total JJ cord-015021-pol2qm74 8774 24 body body NN cord-015021-pol2qm74 8774 25 surface surface NN cord-015021-pol2qm74 8774 26 area area NN cord-015021-pol2qm74 8774 27 has have VBZ cord-015021-pol2qm74 8774 28 not not RB cord-015021-pol2qm74 8774 29 been be VBN cord-015021-pol2qm74 8774 30 spectacular spectacular JJ cord-015021-pol2qm74 8774 31 , , , cord-015021-pol2qm74 8774 32 with with IN cord-015021-pol2qm74 8774 33 poor poor JJ cord-015021-pol2qm74 8774 34 graft graft NN cord-015021-pol2qm74 8774 35 take take NN cord-015021-pol2qm74 8774 36 and and CC cord-015021-pol2qm74 8774 37 unstable unstable JJ cord-015021-pol2qm74 8774 38 epithelium epithelium NN cord-015021-pol2qm74 8774 39 . . . cord-015021-pol2qm74 8775 1 Current current JJ cord-015021-pol2qm74 8775 2 investigations investigation NNS cord-015021-pol2qm74 8775 3 have have VBP cord-015021-pol2qm74 8775 4 been be VBN cord-015021-pol2qm74 8775 5 directed direct VBN cord-015021-pol2qm74 8775 6 toward toward IN cord-015021-pol2qm74 8775 7 dermal dermal JJ cord-015021-pol2qm74 8775 8 replacement replacement NN cord-015021-pol2qm74 8775 9 beneath beneath IN cord-015021-pol2qm74 8775 10 either either CC cord-015021-pol2qm74 8775 11 very very RB cord-015021-pol2qm74 8775 12 thin thin JJ cord-015021-pol2qm74 8775 13 split split NN cord-015021-pol2qm74 8775 14 - - HYPH cord-015021-pol2qm74 8775 15 thickness thickness NN cord-015021-pol2qm74 8775 16 autografts autografts NN cord-015021-pol2qm74 8775 17 ( ( -LRB- cord-015021-pol2qm74 8775 18 STAG STAG NNP cord-015021-pol2qm74 8775 19 ) ) -RRB- cord-015021-pol2qm74 8775 20 or or CC cord-015021-pol2qm74 8775 21 utilizing utilize VBG cord-015021-pol2qm74 8775 22 cultured cultured JJ cord-015021-pol2qm74 8775 23 keratinocytes keratinocyte NNS cord-015021-pol2qm74 8775 24 . . . cord-015021-pol2qm74 8776 1 Current current JJ cord-015021-pol2qm74 8776 2 products product NNS cord-015021-pol2qm74 8776 3 include include VBP cord-015021-pol2qm74 8776 4 : : : cord-015021-pol2qm74 8776 5 Collagen collagen NN cord-015021-pol2qm74 8776 6 dermal dermal JJ cord-015021-pol2qm74 8776 7 replacement replacement NN cord-015021-pol2qm74 8776 8 with with IN cord-015021-pol2qm74 8776 9 thin thin JJ cord-015021-pol2qm74 8776 10 STAG STAG NNP cord-015021-pol2qm74 8776 11 ( ( -LRB- cord-015021-pol2qm74 8776 12 Burke Burke NNP cord-015021-pol2qm74 8776 13 , , , cord-015021-pol2qm74 8776 14 et et NNP cord-015021-pol2qm74 8776 15 al al NNP cord-015021-pol2qm74 8776 16 ) ) -RRB- cord-015021-pol2qm74 8776 17 . . . cord-015021-pol2qm74 8777 1 Collagen collagen NN cord-015021-pol2qm74 8777 2 dermal dermal JJ cord-015021-pol2qm74 8777 3 replacement replacement NN cord-015021-pol2qm74 8777 4 with with IN cord-015021-pol2qm74 8777 5 cultured cultured JJ cord-015021-pol2qm74 8777 6 keratinocytes keratinocyte NNS cord-015021-pol2qm74 8777 7 and and CC cord-015021-pol2qm74 8777 8 fibroblasts fibroblast NNS cord-015021-pol2qm74 8777 9 ( ( -LRB- cord-015021-pol2qm74 8777 10 Boyce Boyce NNP cord-015021-pol2qm74 8777 11 , , , cord-015021-pol2qm74 8777 12 et et NNP cord-015021-pol2qm74 8777 13 aI aI NNP cord-015021-pol2qm74 8777 14 ) ) -RRB- cord-015021-pol2qm74 8777 15 . . . cord-015021-pol2qm74 8778 1 Allograft Allograft NNP cord-015021-pol2qm74 8778 2 dermis dermis NN cord-015021-pol2qm74 8778 3 with with IN cord-015021-pol2qm74 8778 4 cultured cultured JJ cord-015021-pol2qm74 8778 5 keratinocytes keratinocyte NNS cord-015021-pol2qm74 8778 6 ( ( -LRB- cord-015021-pol2qm74 8778 7 Cnno Cnno NNP cord-015021-pol2qm74 8778 8 , , , cord-015021-pol2qm74 8778 9 et et NNP cord-015021-pol2qm74 8778 10 al al NNP cord-015021-pol2qm74 8778 11 ) ) -RRB- cord-015021-pol2qm74 8778 12 . . . cord-015021-pol2qm74 8779 1 Allograft Allograft NNP cord-015021-pol2qm74 8779 2 dermis dermis NN cord-015021-pol2qm74 8779 3 with with IN cord-015021-pol2qm74 8779 4 thin thin JJ cord-015021-pol2qm74 8779 5 STAG stag NN cord-015021-pol2qm74 8779 6 ( ( -LRB- cord-015021-pol2qm74 8779 7 Life Life NNP cord-015021-pol2qm74 8779 8 Cell Cell NNP cord-015021-pol2qm74 8779 9 ) ) -RRB- cord-015021-pol2qm74 8779 10 . . . cord-015021-pol2qm74 8780 1 Polyglactin Polyglactin NNP cord-015021-pol2qm74 8780 2 acid acid NN cord-015021-pol2qm74 8780 3 mesh mesh NN cord-015021-pol2qm74 8780 4 and and CC cord-015021-pol2qm74 8780 5 neonatal neonatal JJ cord-015021-pol2qm74 8780 6 human human JJ cord-015021-pol2qm74 8780 7 fibroblasts fibroblast NNS cord-015021-pol2qm74 8780 8 with with IN cord-015021-pol2qm74 8780 9 thin thin JJ cord-015021-pol2qm74 8780 10 STAG stag NN cord-015021-pol2qm74 8780 11 ( ( -LRB- cord-015021-pol2qm74 8780 12 Hansbrnngh Hansbrnngh NNP cord-015021-pol2qm74 8780 13 , , , cord-015021-pol2qm74 8780 14 et et NNP cord-015021-pol2qm74 8780 15 al).Investigations al).Investigations NNP cord-015021-pol2qm74 8780 16 regarding regard VBG cord-015021-pol2qm74 8780 17 culture culture NN cord-015021-pol2qm74 8780 18 media medium NNS cord-015021-pol2qm74 8780 19 , , , cord-015021-pol2qm74 8780 20 use use NN cord-015021-pol2qm74 8780 21 of of IN cord-015021-pol2qm74 8780 22 growth growth NN cord-015021-pol2qm74 8780 23 factors factor NNS cord-015021-pol2qm74 8780 24 , , , cord-015021-pol2qm74 8780 25 topical topical JJ cord-015021-pol2qm74 8780 26 nutrients nutrient NNS cord-015021-pol2qm74 8780 27 and and CC cord-015021-pol2qm74 8780 28 antibiotics antibiotic NNS cord-015021-pol2qm74 8780 29 , , , cord-015021-pol2qm74 8780 30 and and CC cord-015021-pol2qm74 8780 31 melanocytes melanocyte NNS cord-015021-pol2qm74 8780 32 for for IN cord-015021-pol2qm74 8780 33 pigmentation pigmentation NN cord-015021-pol2qm74 8780 34 as as RB cord-015021-pol2qm74 8780 35 well well RB cord-015021-pol2qm74 8780 36 as as IN cord-015021-pol2qm74 8780 37 safety safety NN cord-015021-pol2qm74 8780 38 and and CC cord-015021-pol2qm74 8780 39 efficacy efficacy NN cord-015021-pol2qm74 8780 40 are be VBP cord-015021-pol2qm74 8780 41 needed need VBN cord-015021-pol2qm74 8780 42 before before IN cord-015021-pol2qm74 8780 43 any any DT cord-015021-pol2qm74 8780 44 of of IN cord-015021-pol2qm74 8780 45 the the DT cord-015021-pol2qm74 8780 46 current current JJ cord-015021-pol2qm74 8780 47 products product NNS cord-015021-pol2qm74 8780 48 become become VBP cord-015021-pol2qm74 8780 49 viable viable JJ cord-015021-pol2qm74 8780 50 options option NNS cord-015021-pol2qm74 8780 51 for for IN cord-015021-pol2qm74 8780 52 coverage coverage NN cord-015021-pol2qm74 8780 53 of of IN cord-015021-pol2qm74 8780 54 the the DT cord-015021-pol2qm74 8780 55 massively massively RB cord-015021-pol2qm74 8780 56 burned burn VBN cord-015021-pol2qm74 8780 57 patient patient NN cord-015021-pol2qm74 8780 58 . . . cord-015021-pol2qm74 8781 1 The~ The~ NNP cord-015021-pol2qm74 8781 2 is be VBZ cord-015021-pol2qm74 8781 3 a a DT cord-015021-pol2qm74 8781 4 growing grow VBG cord-015021-pol2qm74 8781 5 world world NN cord-015021-pol2qm74 8781 6 - - HYPH cord-015021-pol2qm74 8781 7 wide wide JJ cord-015021-pol2qm74 8781 8 problem problem NN cord-015021-pol2qm74 8781 9 with with IN cord-015021-pol2qm74 8781 10 the the DT cord-015021-pol2qm74 8781 11 uJc ujc NN cord-015021-pol2qm74 8781 12 Of of IN cord-015021-pol2qm74 8781 13 cadaver cadaver NN cord-015021-pol2qm74 8781 14 tissues tissue NNS cord-015021-pol2qm74 8781 15 and and CC cord-015021-pol2qm74 8781 16 ocgans ocgans NNP cord-015021-pol2qm74 8781 17 bae bae NNP cord-015021-pol2qm74 8781 18 , , , cord-015021-pol2qm74 8781 19 au~ au~ JJ cord-015021-pol2qm74 8781 20 of of IN cord-015021-pol2qm74 8781 21 the the DT cord-015021-pol2qm74 8781 22 tren~ tren~ NNP cord-015021-pol2qm74 8782 1 m m LS cord-015021-pol2qm74 8783 1 ~s ~s NNP cord-015021-pol2qm74 8783 2 ~ ~ NFP cord-015021-pol2qm74 8783 3 km km NN cord-015021-pol2qm74 8783 4 of of IN cord-015021-pol2qm74 8783 5 dilemma dilemma NN cord-015021-pol2qm74 8783 6 such such PDT cord-015021-pol2qm74 8783 7 a a DT cord-015021-pol2qm74 8784 1 ; ; : cord-015021-pol2qm74 8784 2 Cmutzfeldt Cmutzfeldt NNP cord-015021-pol2qm74 8784 3 . . . cord-015021-pol2qm74 8785 1 Jukob Jukob NNP cord-015021-pol2qm74 8785 2 disease disease NN cord-015021-pol2qm74 8785 3 and and CC cord-015021-pol2qm74 8785 4 IIIV IIIV NNP cord-015021-pol2qm74 8785 5 as as IN cord-015021-pol2qm74 8785 6 we1 we1 NN cord-015021-pol2qm74 8785 7 ] ] -RRB- cord-015021-pol2qm74 8785 8 as as IN cord-015021-pol2qm74 8785 9 ready ready JJ cord-015021-pol2qm74 8785 10 availability availability NN cord-015021-pol2qm74 8785 11 of of IN cord-015021-pol2qm74 8785 12 urdform urdform NNP cord-015021-pol2qm74 8785 13 liS lis NN cord-015021-pol2qm74 8786 1 ~ue~. ~ue~. NNP cord-015021-pol2qm74 8787 1 On on IN cord-015021-pol2qm74 8788 1 Dec~ Dec~ NNP cord-015021-pol2qm74 8789 1 mt mt NNP cord-015021-pol2qm74 8790 1 ~r ~r NNP cord-015021-pol2qm74 8790 2 14 14 CD cord-015021-pol2qm74 8790 3 , , , cord-015021-pol2qm74 8790 4 1993 1993 CD cord-015021-pol2qm74 8790 5 , , , cord-015021-pol2qm74 8790 6 the the DT cord-015021-pol2qm74 8790 7 FDA FDA NNP cord-015021-pol2qm74 8790 8 assumed assume VBD cord-015021-pol2qm74 8790 9 control control NN cord-015021-pol2qm74 8790 10 of of IN cord-015021-pol2qm74 8790 11 aS1 as1 JJ cord-015021-pol2qm74 8790 12 tissue tissue NN cord-015021-pol2qm74 8790 13 bar bar NN cord-015021-pol2qm74 8790 14 ~ ~ NFP cord-015021-pol2qm74 8790 15 s s XX cord-015021-pol2qm74 8790 16 in in IN cord-015021-pol2qm74 8790 17 the the DT cord-015021-pol2qm74 8790 18 Uldtod Uldtod NNP cord-015021-pol2qm74 8790 19 St St NNP cord-015021-pol2qm74 8790 20 = = SYM cord-015021-pol2qm74 8790 21 tea tea NN cord-015021-pol2qm74 8791 1 In in IN cord-015021-pol2qm74 8791 2 an an DT cord-015021-pol2qm74 8791 3 attempt attempt NN cord-015021-pol2qm74 8791 4 to to IN cord-015021-pol2qm74 8791 5 bflng bflng NNP cord-015021-pol2qm74 8792 1 ~s ~s NNP cord-015021-pol2qm74 8792 2 difficult difficult JJ cord-015021-pol2qm74 8792 3 problem problem NN cord-015021-pol2qm74 8792 4 of of IN cord-015021-pol2qm74 8792 5 dise dise NNP cord-015021-pol2qm74 8792 6 ~ ~ NFP cord-015021-pol2qm74 8792 7 s~ s~ CD cord-015021-pol2qm74 8792 8 transmission transmission NN cord-015021-pol2qm74 8792 9 under under IN cord-015021-pol2qm74 8792 10 ¢onlrol ¢onlrol NN cord-015021-pol2qm74 8792 11 . . . cord-015021-pol2qm74 8793 1 In in IN cord-015021-pol2qm74 8793 2 Europe Europe NNP cord-015021-pol2qm74 8793 3 , , , cord-015021-pol2qm74 8793 4 ~om¢ ~om¢ CD cord-015021-pol2qm74 8793 5 of of IN cord-015021-pol2qm74 8793 6 the the DT cord-015021-pol2qm74 8793 7 governments government NNS cord-015021-pol2qm74 8793 8 are be VBP cord-015021-pol2qm74 8793 9 consldofll~ consldofll~ VBZ cord-015021-pol2qm74 8793 10 a a DT cord-015021-pol2qm74 8793 11 c c NN cord-015021-pol2qm74 8793 12 ~ ~ NFP cord-015021-pol2qm74 8793 13 mplcte mplcte NNP cord-015021-pol2qm74 8793 14 bat bat NNP cord-015021-pol2qm74 8793 15 ) ) -RRB- cord-015021-pol2qm74 8793 16 on on IN cord-015021-pol2qm74 8793 17 the the DT cord-015021-pol2qm74 8793 18 use use NN cord-015021-pol2qm74 8793 19 of of IN cord-015021-pol2qm74 8793 20 cadaverlc cadaverlc NNP cord-015021-pol2qm74 8793 21 fissu fissu NNP cord-015021-pol2qm74 8793 22 ~ ~ NFP cord-015021-pol2qm74 8793 23 S S NNP cord-015021-pol2qm74 8793 24 such such JJ cord-015021-pol2qm74 8793 25 as as IN cord-015021-pol2qm74 8793 26 ddn ddn NNP cord-015021-pol2qm74 8793 27 , , , cord-015021-pol2qm74 8793 28 ' ' `` cord-015021-pol2qm74 8793 29 This this DT cord-015021-pol2qm74 8793 30 |ncroam |ncroam NNP cord-015021-pol2qm74 8793 31 in in IN cord-015021-pol2qm74 8793 32 regulation regulation NN cord-015021-pol2qm74 8793 33 of of IN cord-015021-pol2qm74 8793 34 cadavefle cadavefle NN cord-015021-pol2qm74 8794 1 ~s ~s NNP cord-015021-pol2qm74 8795 1 , , , cord-015021-pol2qm74 8795 2 quct quct NNP cord-015021-pol2qm74 8795 3 will will MD cord-015021-pol2qm74 8795 4 incmar¢ incmar¢ VB cord-015021-pol2qm74 8795 5 the the DT cord-015021-pol2qm74 8795 6 difficulty difficulty NN cord-015021-pol2qm74 8795 7 of of IN cord-015021-pol2qm74 8795 8 obtain obtain VB cord-015021-pol2qm74 8795 9 ~ ~ NFP cord-015021-pol2qm74 8795 10 g g NN cord-015021-pol2qm74 8795 11 and and CC cord-015021-pol2qm74 8795 12 dlslflbuLmg dlslflbuLmg NNP cord-015021-pol2qm74 8795 13 them -PRON- PRP cord-015021-pol2qm74 8795 14 . . . cord-015021-pol2qm74 8796 1 However however RB cord-015021-pol2qm74 8796 2 , , , cord-015021-pol2qm74 8796 3 thc thc NNP cord-015021-pol2qm74 8796 4 nc~ nc~ NN cord-015021-pol2qm74 8796 5 for for IN cord-015021-pol2qm74 8796 6 these these DT cord-015021-pol2qm74 8796 7 tissues tissue NNS cord-015021-pol2qm74 8797 1 contlnue~ contlnue~ NNP cord-015021-pol2qm74 8797 2 m m CD cord-015021-pol2qm74 8797 3 incrcaso incrcaso NNP cord-015021-pol2qm74 8798 1 , , , cord-015021-pol2qm74 8798 2 We -PRON- PRP cord-015021-pol2qm74 8798 3 will will MD cord-015021-pol2qm74 8798 4 discuss discuss VB cord-015021-pol2qm74 8798 5 ~'L¢ ~'l¢ CD cord-015021-pol2qm74 8798 6 solulion solulion NN cord-015021-pol2qm74 8798 7 to to IN cord-015021-pol2qm74 8798 8 this this DT cord-015021-pol2qm74 8798 9 Important Important NNP cord-015021-pol2qm74 8798 10 pmbl~ pmbl~ NNP cord-015021-pol2qm74 8799 1 n n CC cord-015021-pol2qm74 8799 2 : : : cord-015021-pol2qm74 8799 3 Tissue tissue NN cord-015021-pol2qm74 8799 4 Engineering Engineering NNP cord-015021-pol2qm74 8799 5 . . . cord-015021-pol2qm74 8800 1 Tlssu~ tlssu~ CD cord-015021-pol2qm74 8801 1 Engineering engineering NN cord-015021-pol2qm74 8801 2 is be VBZ cord-015021-pol2qm74 8801 3 an an DT cord-015021-pol2qm74 8801 4 in in IN cord-015021-pol2qm74 8801 5 ~ ~ NFP cord-015021-pol2qm74 8801 6 rdisdpllnary rdisdpllnary NNP cord-015021-pol2qm74 8801 7 field field NN cord-015021-pol2qm74 8801 8 that that WDT cord-015021-pol2qm74 8801 9 applies apply VBZ cord-015021-pol2qm74 8801 10 pdnclplc~ pdnclplc~ NNP cord-015021-pol2qm74 8801 11 of of IN cord-015021-pol2qm74 8801 12 angin angin NNP cord-015021-pol2qm74 8801 13 ~ ~ NFP cord-015021-pol2qm74 8801 14 edng edng NNP cord-015021-pol2qm74 8801 15 and and CC cord-015021-pol2qm74 8801 16 die die VB cord-015021-pol2qm74 8801 17 life life NN cord-015021-pol2qm74 8802 1 sclcnce~ sclcnce~ NNP cord-015021-pol2qm74 8802 2 reward reward VB cord-015021-pol2qm74 8802 3 the the DT cord-015021-pol2qm74 8802 4 development development NN cord-015021-pol2qm74 8802 5 of of IN cord-015021-pol2qm74 8802 6 ~olok~¢al ~olok~¢al NFP cord-015021-pol2qm74 8802 7 sub sub NNP cord-015021-pol2qm74 8802 8 ~ ~ NNP cord-015021-pol2qm74 8802 9 dtute,~ dtute,~ JJ cord-015021-pol2qm74 8802 10 Ih= Ih= NNP cord-015021-pol2qm74 8802 11 mslom mslom NN cord-015021-pol2qm74 8802 12 , , , cord-015021-pol2qm74 8802 13 maintain maintain VB cord-015021-pol2qm74 8802 14 , , , cord-015021-pol2qm74 8802 15 or or CC cord-015021-pol2qm74 8802 16 improve improve VB cord-015021-pol2qm74 8802 17 tissue tissue NN cord-015021-pol2qm74 8802 18 function function NN cord-015021-pol2qm74 8802 19 , , . cord-015021-pol2qm74 8803 1 " " `` cord-015021-pol2qm74 8803 2 13ssuc 13ssuc CD cord-015021-pol2qm74 8803 3 ongln ongln NN cord-015021-pol2qm74 8804 1 ~cdng ~cdng NNP cord-015021-pol2qm74 8804 2 can can MD cord-015021-pol2qm74 8804 3 provide provide VB cord-015021-pol2qm74 8804 4 ~ho ~ho NNS cord-015021-pol2qm74 8805 1 nccassary nccassary NNP cord-015021-pol2qm74 8805 2 tlssuoa tlssuoa NNP cord-015021-pol2qm74 8805 3 for for IN cord-015021-pol2qm74 8805 4 wound wound NN cord-015021-pol2qm74 8805 5 repair repair NN cord-015021-pol2qm74 8806 1 ~d ~d . cord-015021-pol2qm74 8807 1 Ibe Ibe NNP cord-015021-pol2qm74 8807 2 assuranoe assuranoe NNP cord-015021-pol2qm74 8807 3 fl'~t fl'~t NNP cord-015021-pol2qm74 8808 1 the the DT cord-015021-pol2qm74 8808 2 lissuos lissuos NNP cord-015021-pol2qm74 8808 3 are be VBP cord-015021-pol2qm74 8808 4 d.ls¢~¢ d.ls¢~¢ CD cord-015021-pol2qm74 8808 5 free free JJ cord-015021-pol2qm74 8808 6 . . . cord-015021-pol2qm74 8809 1 In in IN cord-015021-pol2qm74 8809 2 addition addition NN cord-015021-pol2qm74 8809 3 , , , cord-015021-pol2qm74 8809 4 a a DT cord-015021-pol2qm74 8809 5 ds ds NNP cord-015021-pol2qm74 8809 6 ~ ~ NNP cord-015021-pol2qm74 8809 7 uo uo NNP cord-015021-pol2qm74 8809 8 - - HYPH cord-015021-pol2qm74 8809 9 cng cng NNP cord-015021-pol2qm74 8809 10 ~ ~ NNP cord-015021-pol2qm74 8809 11 ne ne NNP cord-015021-pol2qm74 8809 12 ~ ~ NNP cord-015021-pol2qm74 8809 13 n n NN cord-015021-pol2qm74 8809 14 ~ ~ NFP cord-015021-pol2qm74 8809 15 l l NNP cord-015021-pol2qm74 8809 16 wound wound NNP cord-015021-pol2qm74 8809 17 covering cover VBG cord-015021-pol2qm74 8809 18 will will MD cord-015021-pol2qm74 8809 19 bo bo NNP cord-015021-pol2qm74 8809 20 u u NNP cord-015021-pol2qm74 8809 21 ~ ~ NFP cord-015021-pol2qm74 8809 22 lvemally lvemally RB cord-015021-pol2qm74 8809 23 acceptable acceptable JJ cord-015021-pol2qm74 8809 24 and and CC cord-015021-pol2qm74 8809 25 evntlublc evntlublc JJ cord-015021-pol2qm74 8809 26 as as IN cord-015021-pol2qm74 8809 27 " " `` cord-015021-pol2qm74 8809 28 off off IN cord-015021-pol2qm74 8809 29 G g NN cord-015021-pol2qm74 8809 30 ~ ~ NFP cord-015021-pol2qm74 8809 31 o o UH cord-015021-pol2qm74 8809 32 shell shell NN cord-015021-pol2qm74 8809 33 " " '' cord-015021-pol2qm74 8809 34 , , , cord-015021-pol2qm74 8809 35 consis consis NNP cord-015021-pol2qm74 8809 36 ~ ~ NFP cord-015021-pol2qm74 8809 37 t t NNP cord-015021-pol2qm74 8809 38 products product NNS cord-015021-pol2qm74 8809 39 , , , cord-015021-pol2qm74 8809 40 Them -PRON- PRP cord-015021-pol2qm74 8809 41 are be VBP cord-015021-pol2qm74 8809 42 several several JJ cord-015021-pol2qm74 8809 43 approaches approach NNS cord-015021-pol2qm74 8809 44 to to IN cord-015021-pol2qm74 8809 45 restating restate VBG cord-015021-pol2qm74 8809 46 thls thls NNP cord-015021-pol2qm74 8809 47 function function NN cord-015021-pol2qm74 8809 48 in in IN cord-015021-pol2qm74 8809 49 a a DT cord-015021-pol2qm74 8809 50 large large JJ cord-015021-pol2qm74 8809 51 wound wound NN cord-015021-pol2qm74 8809 52 , , , cord-015021-pol2qm74 8809 53 ' ' '' cord-015021-pol2qm74 8810 1 l'nosc l'nosc NNP cord-015021-pol2qm74 8810 2 i i NNP cord-015021-pol2qm74 8811 1 ~elud~ ~elud~ NNP cord-015021-pol2qm74 8811 2 tmmcdiete tmmcdiete JJ cord-015021-pol2qm74 8811 3 long long JJ cord-015021-pol2qm74 8811 4 term term NN cord-015021-pol2qm74 8811 5 coverage coverage NN cord-015021-pol2qm74 8811 6 , , , cord-015021-pol2qm74 8811 7 short short JJ cord-015021-pol2qm74 8811 8 t t NN cord-015021-pol2qm74 8811 9 = = SYM cord-015021-pol2qm74 8811 10 nn nn NNP cord-015021-pol2qm74 8811 11 coverage coverage NN cord-015021-pol2qm74 8811 12 , , , cord-015021-pol2qm74 8811 13 uandtl uandtl NNP cord-015021-pol2qm74 8811 14 ~ ~ NFP cord-015021-pol2qm74 8811 15 el el NNP cord-015021-pol2qm74 8811 16 coverage coverage NN cord-015021-pol2qm74 8811 17 and and CC cord-015021-pol2qm74 8811 18 compost= compost= NNP cord-015021-pol2qm74 8811 19 dssu¢ dssu¢ NNP cord-015021-pol2qm74 8811 20 coverage coverage NN cord-015021-pol2qm74 8811 21 , , , cord-015021-pol2qm74 8811 22 " " `` cord-015021-pol2qm74 8811 23 flssuo flssuo NNP cord-015021-pol2qm74 8811 24 onglncrcd onglncrcd NNP cord-015021-pol2qm74 8811 25 wound wound VBP cord-015021-pol2qm74 8811 26 coverings covering NNS cord-015021-pol2qm74 8811 27 that that WDT cord-015021-pol2qm74 8811 28 meet meet VBP cord-015021-pol2qm74 8811 29 those those DT cord-015021-pol2qm74 8811 30 vaflous vaflous JJ cord-015021-pol2qm74 8812 1 ne,.cds ne,.cds NNP cord-015021-pol2qm74 8813 1 will will MD cord-015021-pol2qm74 8813 2 he -PRON- PRP cord-015021-pol2qm74 8813 3 r r VB cord-015021-pol2qm74 8813 4 ~ ~ CD cord-015021-pol2qm74 8813 5 vlowod vlowod NN cord-015021-pol2qm74 8813 6 . . . cord-015021-pol2qm74 8814 1 Cllni~:sl Cllni~:sl NNP cord-015021-pol2qm74 8814 2 and and CC cord-015021-pol2qm74 8814 3 experimental experimental JJ cord-015021-pol2qm74 8814 4 d d NN cord-015021-pol2qm74 8815 1 ~la ~la NNS cord-015021-pol2qm74 8815 2 in in IN cord-015021-pol2qm74 8815 3 venous venous JJ cord-015021-pol2qm74 8815 4 ulcer ulcer NN cord-015021-pol2qm74 8815 5 , , , cord-015021-pol2qm74 8815 6 dlabctl¢ dlabctl¢ NNS cord-015021-pol2qm74 8815 7 ulcers ulcer NNS cord-015021-pol2qm74 8815 8 , , , cord-015021-pol2qm74 8815 9 prossur~ prossur~ JJ cord-015021-pol2qm74 8815 10 ulcers ulcer NNS cord-015021-pol2qm74 8815 11 and and CC cord-015021-pol2qm74 8815 12 bum bum NN cord-015021-pol2qm74 8815 13 wounds wound NNS cord-015021-pol2qm74 8815 14 wgJ wgJ NNS cord-015021-pol2qm74 8815 15 be be VBP cord-015021-pol2qm74 8815 16 mvlcw~ mvlcw~ FW cord-015021-pol2qm74 8815 17 , , , cord-015021-pol2qm74 8815 18 a~ a~ : cord-015021-pol2qm74 8815 19 welt welt NN cord-015021-pol2qm74 8815 20 as as IN cord-015021-pol2qm74 8815 21 new new JJ cord-015021-pol2qm74 8815 22 approacl~ approacl~ NNP cord-015021-pol2qm74 8816 1 s s NNP cord-015021-pol2qm74 8816 2 U~ U~ NNP cord-015021-pol2qm74 8816 3 csrtilag¢ csrtilag¢ NN cord-015021-pol2qm74 8816 4 , , , cord-015021-pol2qm74 8816 5 bone bone NN cord-015021-pol2qm74 8816 6 , , , cord-015021-pol2qm74 8816 7 liver liver NN cord-015021-pol2qm74 8816 8 and and CC cord-015021-pol2qm74 8816 9 bone bone NN cord-015021-pol2qm74 8816 10 marrow marrow NN cord-015021-pol2qm74 8817 1 It -PRON- PRP cord-015021-pol2qm74 8817 2 ~ ~ NFP cord-015021-pol2qm74 8817 3 Suos Suos NNP cord-015021-pol2qm74 8817 4 . . . cord-015021-pol2qm74 8818 1 C C NNP cord-015021-pol2qm74 8818 2 Oomplon Oomplon NNP cord-015021-pol2qm74 8818 3 , , , cord-015021-pol2qm74 8818 4 K K NNP cord-015021-pol2qm74 8818 5 Nadirs Nadirs NNP cord-015021-pol2qm74 8818 6 , , , cord-015021-pol2qm74 8818 7 W W NNP cord-015021-pol2qm74 8818 8 Press Press NNP cord-015021-pol2qm74 8818 9 , , , cord-015021-pol2qm74 8818 10 G G NNP cord-015021-pol2qm74 8818 11 Wetland Wetland NNP cord-015021-pol2qm74 8818 12 , , , cord-015021-pol2qm74 8818 13 J J NNP cord-015021-pol2qm74 8818 14 Fallen Fallen NNP cord-015021-pol2qm74 8818 15 IV IV NNP cord-015021-pol2qm74 8818 16 , , , cord-015021-pol2qm74 8818 17 Shrtners Shrtners NNP cord-015021-pol2qm74 8818 18 Burns Burns NNP cord-015021-pol2qm74 8818 19 Institute Institute NNP cord-015021-pol2qm74 8818 20 and and CC cord-015021-pol2qm74 8818 21 Massachusetts Massachusetts NNP cord-015021-pol2qm74 8818 22 General General NNP cord-015021-pol2qm74 8818 23 Hospital Hospital NNP cord-015021-pol2qm74 8818 24 , , , cord-015021-pol2qm74 8818 25 Boston Boston NNP cord-015021-pol2qm74 8818 26 , , , cord-015021-pol2qm74 8818 27 Ma Ma NNP cord-015021-pol2qm74 8818 28 ~ ~ NNP cord-015021-pol2qm74 8818 29 schusetts schusetts NNP cord-015021-pol2qm74 8818 30 , , , cord-015021-pol2qm74 8818 31 USA USA NNP cord-015021-pol2qm74 8819 1 The the DT cord-015021-pol2qm74 8819 2 clinical clinical JJ cord-015021-pol2qm74 8819 3 " " `` cord-015021-pol2qm74 8819 4 take take VB cord-015021-pol2qm74 8819 5 " " '' cord-015021-pol2qm74 8819 6 rate rate NN cord-015021-pol2qm74 8819 7 o o NN cord-015021-pol2qm74 8819 8 ? ? . cord-015021-pol2qm74 8819 9 cultured cultured JJ cord-015021-pol2qm74 8819 10 epithelial epithelial JJ cord-015021-pol2qm74 8819 11 autografts autografts NNP cord-015021-pol2qm74 8819 12 ( ( -LRB- cord-015021-pol2qm74 8819 13 CEA CEA NNP cord-015021-pol2qm74 8819 14 ) ) -RRB- cord-015021-pol2qm74 8819 15 has have VBZ cord-015021-pol2qm74 8819 16 been be VBN cord-015021-pol2qm74 8819 17 observed observe VBN cord-015021-pol2qm74 8819 18 to to TO cord-015021-pol2qm74 8819 19 Increase increase VB cord-015021-pol2qm74 8819 20 with with IN cord-015021-pol2qm74 8819 21 transplantation transplantation NN cord-015021-pol2qm74 8819 22 to to IN cord-015021-pol2qm74 8819 23 allodermls allodermls NNP cord-015021-pol2qm74 8819 24 , , , cord-015021-pol2qm74 8819 25 but but CC cord-015021-pol2qm74 8819 26 the the DT cord-015021-pol2qm74 8819 27 reasons reason NNS cord-015021-pol2qm74 8819 28 for for IN cord-015021-pol2qm74 8819 29 the the DT cord-015021-pol2qm74 8819 30 improved improved JJ cord-015021-pol2qm74 8819 31 clinical clinical JJ cord-015021-pol2qm74 8819 32 performance performance NN cord-015021-pol2qm74 8819 33 have have VBP cord-015021-pol2qm74 8819 34 not not RB cord-015021-pol2qm74 8819 35 yet yet RB cord-015021-pol2qm74 8819 36 been be VBN cord-015021-pol2qm74 8819 37 defined define VBN cord-015021-pol2qm74 8819 38 . . . cord-015021-pol2qm74 8820 1 The the DT cord-015021-pol2qm74 8820 2 aim aim NN cord-015021-pol2qm74 8820 3 of of IN cord-015021-pol2qm74 8820 4 this this DT cord-015021-pol2qm74 8820 5 study study NN cord-015021-pol2qm74 8820 6 was be VBD cord-015021-pol2qm74 8820 7 to to TO cord-015021-pol2qm74 8820 8 determine determine VB cord-015021-pol2qm74 8820 9 the the DT cord-015021-pol2qm74 8820 10 biological biological JJ cord-015021-pol2qm74 8820 11 impact impact NN cord-015021-pol2qm74 8820 12 of of IN cord-015021-pol2qm74 8820 13 normal normal JJ cord-015021-pol2qm74 8820 14 human human JJ cord-015021-pol2qm74 8820 15 dermis dermis NN cord-015021-pol2qm74 8820 16 on on IN cord-015021-pol2qm74 8820 17 CEA CEA NNP cord-015021-pol2qm74 8820 18 differentiation differentiation NN cord-015021-pol2qm74 8820 19 and and CC cord-015021-pol2qm74 8820 20 maturation maturation NN cord-015021-pol2qm74 8820 21 , , , cord-015021-pol2qm74 8820 22 Biopsies biopsy NNS cord-015021-pol2qm74 8820 23 of of IN cord-015021-pol2qm74 8820 24 CEA CEA NNP cord-015021-pol2qm74 8820 25 transplanted transplant VBD cord-015021-pol2qm74 8820 26 to to IN cord-015021-pol2qm74 8820 27 engrafted engraft VBN cord-015021-pol2qm74 8820 28 and and CC cord-015021-pol2qm74 8821 1 de de JJ cord-015021-pol2qm74 8821 2 - - JJ cord-015021-pol2qm74 8821 3 opldermlzed opldermlzed JJ cord-015021-pol2qm74 8821 4 human human JJ cord-015021-pol2qm74 8821 5 homograft homograft NN cord-015021-pol2qm74 8821 6 dermis dermis NN cord-015021-pol2qm74 8821 7 have have VBP cord-015021-pol2qm74 8821 8 been be VBN cord-015021-pol2qm74 8821 9 compared compare VBN cord-015021-pol2qm74 8821 10 to to IN cord-015021-pol2qm74 8821 11 Nopsles Nopsles NNP cord-015021-pol2qm74 8821 12 of of IN cord-015021-pol2qm74 8821 13 CEA CEA NNP cord-015021-pol2qm74 8821 14 transplanted transplant VBD cord-015021-pol2qm74 8821 15 to to IN cord-015021-pol2qm74 8821 16 granulation granulation NN cord-015021-pol2qm74 8821 17 tissue tissue NN cord-015021-pol2qm74 8822 1 In in IN cord-015021-pol2qm74 8822 2 tullthickness tullthickness NN cord-015021-pol2qm74 8822 3 burn burn NN cord-015021-pol2qm74 8822 4 wound wind VBD cord-015021-pol2qm74 8822 5 beds bed NNS cord-015021-pol2qm74 8822 6 on on IN cord-015021-pol2qm74 8822 7 the the DT cord-015021-pol2qm74 8822 8 same same JJ cord-015021-pol2qm74 8822 9 patient patient NN cord-015021-pol2qm74 8822 10 , , , cord-015021-pol2qm74 8822 11 each each DT cord-015021-pol2qm74 8822 12 patient patient NN cord-015021-pol2qm74 8822 13 serving serve VBG cord-015021-pol2qm74 8822 14 as as IN cord-015021-pol2qm74 8822 15 hls hls NNP cord-015021-pol2qm74 8822 16 or or CC cord-015021-pol2qm74 8822 17 her -PRON- PRP$ cord-015021-pol2qm74 8822 18 own own JJ cord-015021-pol2qm74 8822 19 control control NN cord-015021-pol2qm74 8822 20 . . . cord-015021-pol2qm74 8823 1 Paired paired JJ cord-015021-pol2qm74 8823 2 test test NN cord-015021-pol2qm74 8823 3 and and CC cord-015021-pol2qm74 8823 4 control control NN cord-015021-pol2qm74 8823 5 biopstes biopste NNS cord-015021-pol2qm74 8823 6 from from IN cord-015021-pol2qm74 8823 7 six six CD cord-015021-pol2qm74 8823 8 patients patient NNS cord-015021-pol2qm74 8823 9 have have VBP cord-015021-pol2qm74 8823 10 acquired acquire VBN cord-015021-pol2qm74 8823 11 from from IN cord-015021-pol2qm74 8823 12 as as RB cord-015021-pol2qm74 8823 13 early early RB cord-015021-pol2qm74 8823 14 as as IN cord-015021-pol2qm74 8823 15 one one CD cord-015021-pol2qm74 8823 16 week week NN cord-015021-pol2qm74 8823 17 postgrafting postgrafting NN cord-015021-pol2qm74 8823 18 to to IN cord-015021-pol2qm74 8823 19 as as RB cord-015021-pol2qm74 8823 20 late late JJ cord-015021-pol2qm74 8823 21 as as IN cord-015021-pol2qm74 8823 22 3 3 CD cord-015021-pol2qm74 8823 23 years year NNS cord-015021-pol2qm74 8823 24 postgrafting postgrafting JJ cord-015021-pol2qm74 8823 25 ( ( -LRB- cord-015021-pol2qm74 8823 26 one one CD cord-015021-pol2qm74 8823 27 patient patient NN cord-015021-pol2qm74 8823 28 ) ) -RRB- cord-015021-pol2qm74 8823 29 and and CC cord-015021-pol2qm74 8823 30 analyzed analyze VBN cord-015021-pol2qm74 8823 31 histopathologlcally histopathologlcally RB cord-015021-pol2qm74 8823 32 , , , cord-015021-pol2qm74 8823 33 ultrastructurally ultrastructurally NN cord-015021-pol2qm74 8823 34 and and CC cord-015021-pol2qm74 8823 35 immunoh[stochemloally immunoh[stochemloally RB cord-015021-pol2qm74 8823 36 , , , cord-015021-pol2qm74 8823 37 Results result NNS cord-015021-pol2qm74 8823 38 demonstrate demonstrate VBP cord-015021-pol2qm74 8823 39 more more RBR cord-015021-pol2qm74 8823 40 rapid rapid JJ cord-015021-pol2qm74 8823 41 normalization normalization NN cord-015021-pol2qm74 8823 42 of of IN cord-015021-pol2qm74 8823 43 differentiation differentiation NN cord-015021-pol2qm74 8823 44 markers marker NNS cord-015021-pol2qm74 8823 45 ( ( -LRB- cord-015021-pol2qm74 8823 46 e e NN cord-015021-pol2qm74 8823 47 , , , cord-015021-pol2qm74 8823 48 g g NNP cord-015021-pol2qm74 8823 49 . . NNP cord-015021-pol2qm74 8823 50 , , , cord-015021-pol2qm74 8823 51 Involucfln Involucfln NNP cord-015021-pol2qm74 8823 52 , , , cord-015021-pol2qm74 8823 53 fllaggrln fllaggrln NNP cord-015021-pol2qm74 8823 54 , , , cord-015021-pol2qm74 8823 55 cytokeratln cytokeratln NNP cord-015021-pol2qm74 8823 56 profiles profile NNS cord-015021-pol2qm74 8823 57 ) ) -RRB- cord-015021-pol2qm74 8823 58 in in IN cord-015021-pol2qm74 8823 59 the the DT cord-015021-pol2qm74 8823 60 CEA CEA NNP cord-015021-pol2qm74 8823 61 transplanted transplant VBD cord-015021-pol2qm74 8823 62 to to IN cord-015021-pol2qm74 8823 63 allodermls allodermls NNP cord-015021-pol2qm74 8823 64 compared compare VBN cord-015021-pol2qm74 8823 65 to to IN cord-015021-pol2qm74 8823 66 their -PRON- PRP$ cord-015021-pol2qm74 8823 67 corresponding corresponding JJ cord-015021-pol2qm74 8823 68 controls control NNS cord-015021-pol2qm74 8823 69 by by IN cord-015021-pol2qm74 8823 70 in in IN cord-015021-pol2qm74 8823 71 all all DT cord-015021-pol2qm74 8823 72 patients patient NNS cord-015021-pol2qm74 8823 73 , , , cord-015021-pol2qm74 8823 74 The the DT cord-015021-pol2qm74 8823 75 proliferation proliferation NN cord-015021-pol2qm74 8823 76 rate rate NN cord-015021-pol2qm74 8823 77 within within IN cord-015021-pol2qm74 8823 78 the the DT cord-015021-pol2qm74 8823 79 basal basal NN cord-015021-pol2qm74 8823 80 layer layer NN cord-015021-pol2qm74 8823 81 ot ot VBP cord-015021-pol2qm74 8823 82 the the DT cord-015021-pol2qm74 8823 83 epidermis epidermis NN cord-015021-pol2qm74 8823 84 as as IN cord-015021-pol2qm74 8823 85 determined determine VBN cord-015021-pol2qm74 8823 86 by by IN cord-015021-pol2qm74 8824 1 Ki-67 Ki-67 . cord-015021-pol2qm74 8825 1 ( ( -LRB- cord-015021-pol2qm74 8825 2 proliferation proliferation NN cord-015021-pol2qm74 8825 3 - - HYPH cord-015021-pol2qm74 8825 4 associated associate VBN cord-015021-pol2qm74 8825 5 antigen antigen NN cord-015021-pol2qm74 8825 6 ) ) -RRB- cord-015021-pol2qm74 8825 7 Is be VBZ cord-015021-pol2qm74 8825 8 seen see VBN cord-015021-pol2qm74 8825 9 to to TO cord-015021-pol2qm74 8825 10 norh norh VB cord-015021-pol2qm74 8825 11 ~ ~ NFP cord-015021-pol2qm74 8825 12 altze altze NNPS cord-015021-pol2qm74 8825 13 more more RBR cord-015021-pol2qm74 8825 14 quickly quickly RB cord-015021-pol2qm74 8826 1 In in IN cord-015021-pol2qm74 8826 2 the the DT cord-015021-pol2qm74 8826 3 CEA CEA NNP cord-015021-pol2qm74 8826 4 transplanted transplant VBD cord-015021-pol2qm74 8826 5 to to IN cord-015021-pol2qm74 8826 6 allodermls allodermls NNP cord-015021-pol2qm74 8826 7 in in IN cord-015021-pol2qm74 8826 8 every every DT cord-015021-pol2qm74 8826 9 case case NN cord-015021-pol2qm74 8826 10 , , , cord-015021-pol2qm74 8826 11 Persistence Persistence NNP cord-015021-pol2qm74 8826 12 of of IN cord-015021-pol2qm74 8826 13 allodermal allodermal JJ cord-015021-pol2qm74 8826 14 matrix matrix NN cord-015021-pol2qm74 8826 15 can can MD cord-015021-pol2qm74 8826 16 be be VB cord-015021-pol2qm74 8826 17 doOumented dooumente VBN cord-015021-pol2qm74 8826 18 In in IN cord-015021-pol2qm74 8826 19 all all DT cord-015021-pol2qm74 8826 20 patients patient NNS cord-015021-pol2qm74 8826 21 by by IN cord-015021-pol2qm74 8826 22 elastic elastic JJ cord-015021-pol2qm74 8826 23 tlssue tlssue RB cord-015021-pol2qm74 8826 24 - - HYPH cord-015021-pol2qm74 8826 25 trichrome trichrome JJ cord-015021-pol2qm74 8826 26 stain stain NN cord-015021-pol2qm74 8826 27 , , , cord-015021-pol2qm74 8826 28 allowing allow VBG cord-015021-pol2qm74 8826 29 visualization visualization NN cord-015021-pol2qm74 8826 30 of of IN cord-015021-pol2qm74 8826 31 the the DT cord-015021-pol2qm74 8826 32 dermal dermal JJ cord-015021-pol2qm74 8826 33 elastin elastin NN cord-015021-pol2qm74 8826 34 network network NN cord-015021-pol2qm74 8826 35 . . . cord-015021-pol2qm74 8827 1 The the DT cord-015021-pol2qm74 8827 2 popu;atlon popu;atlon NN cord-015021-pol2qm74 8827 3 densities density NNS cord-015021-pol2qm74 8827 4 ot ot VBP cord-015021-pol2qm74 8828 1 Intraepldarmal Intraepldarmal NNP cord-015021-pol2qm74 8828 2 Langerhans Langerhans NNP cord-015021-pol2qm74 8828 3 cells cell NNS cord-015021-pol2qm74 8828 4 are be VBP cord-015021-pol2qm74 8828 5 conslstently conslstently RB cord-015021-pol2qm74 8828 6 and and CC cord-015021-pol2qm74 8828 7 signlflcantly signlflcantly RB cord-015021-pol2qm74 8828 8 higher high JJR cord-015021-pol2qm74 8829 1 In in IN cord-015021-pol2qm74 8829 2 CEA CEA NNP cord-015021-pol2qm74 8829 3 transplanted transplant VBD cord-015021-pol2qm74 8829 4 to to IN cord-015021-pol2qm74 8829 5 , , , cord-015021-pol2qm74 8829 6 allodermls allodermls NNP cord-015021-pol2qm74 8829 7 , , , cord-015021-pol2qm74 8829 8 possibly possibly RB cord-015021-pol2qm74 8829 9 reflectlng reflectlng VB cord-015021-pol2qm74 8829 10 an an DT cord-015021-pol2qm74 8829 11 Immunologlcal Immunologlcal NNP cord-015021-pol2qm74 8829 12 reaction reaction NN cord-015021-pol2qm74 8829 13 to to IN cord-015021-pol2qm74 8829 14 the the DT cord-015021-pol2qm74 8829 15 underlying underlying JJ cord-015021-pol2qm74 8829 16 allogenlc allogenlc JJ cord-015021-pol2qm74 8829 17 tissue tissue NN cord-015021-pol2qm74 8829 18 . . . cord-015021-pol2qm74 8830 1 Overall overall RB cord-015021-pol2qm74 8830 2 , , , cord-015021-pol2qm74 8830 3 these these DT cord-015021-pol2qm74 8830 4 preliminary preliminary JJ cord-015021-pol2qm74 8830 5 results result NNS cord-015021-pol2qm74 8830 6 indicate indicate VBP cord-015021-pol2qm74 8830 7 that that IN cord-015021-pol2qm74 8830 8 transplantation transplantation NN cord-015021-pol2qm74 8830 9 to to IN cord-015021-pol2qm74 8830 10 a a DT cord-015021-pol2qm74 8830 11 normal normal JJ cord-015021-pol2qm74 8830 12 human human JJ cord-015021-pol2qm74 8830 13 dermal dermal NN cord-015021-pol2qm74 8830 14 matrix matrix NN cord-015021-pol2qm74 8830 15 accelerates accelerate VBZ cord-015021-pol2qm74 8830 16 the the DT cord-015021-pol2qm74 8830 17 maturation maturation NN cord-015021-pol2qm74 8830 18 of of IN cord-015021-pol2qm74 8830 19 CEA CEA NNP cord-015021-pol2qm74 8830 20 - - HYPH cord-015021-pol2qm74 8830 21 deflved deflved NNP cord-015021-pol2qm74 8830 22 epidermis epidermis NN cord-015021-pol2qm74 8830 23 , , , cord-015021-pol2qm74 8830 24 Wound Wound NNP cord-015021-pol2qm74 8830 25 closure closure NN cord-015021-pol2qm74 8830 26 continues continue VBZ cord-015021-pol2qm74 8830 27 to to TO cord-015021-pol2qm74 8830 28 be be VB cord-015021-pol2qm74 8830 29 a a DT cord-015021-pol2qm74 8830 30 major major JJ cord-015021-pol2qm74 8830 31 problem problem NN cord-015021-pol2qm74 8830 32 in in IN cord-015021-pol2qm74 8830 33 patients patient NNS cord-015021-pol2qm74 8830 34 who who WP cord-015021-pol2qm74 8830 35 have have VBP cord-015021-pol2qm74 8830 36 sustained sustain VBN cord-015021-pol2qm74 8830 37 a a DT cord-015021-pol2qm74 8830 38 major major JJ cord-015021-pol2qm74 8830 39 thermal thermal JJ cord-015021-pol2qm74 8830 40 InJury InJury NNP cord-015021-pol2qm74 8830 41 , , , cord-015021-pol2qm74 8830 42 Cultured cultured JJ cord-015021-pol2qm74 8830 43 epidermal epidermal JJ cord-015021-pol2qm74 8830 44 autografts autograft NNS cord-015021-pol2qm74 8830 45 ( ( -LRB- cord-015021-pol2qm74 8830 46 CEA CEA NNP cord-015021-pol2qm74 8830 47 ) ) -RRB- cord-015021-pol2qm74 8830 48 have have VBP cord-015021-pol2qm74 8830 49 been be VBN cord-015021-pol2qm74 8830 50 utilized utilize VBN cord-015021-pol2qm74 8830 51 extensively extensively RB cord-015021-pol2qm74 8830 52 since since IN cord-015021-pol2qm74 8830 53 1984 1984 CD cord-015021-pol2qm74 8830 54 when when WRB cord-015021-pol2qm74 8830 55 Galllco Galllco NNP cord-015021-pol2qm74 8830 56 et et NNP cord-015021-pol2qm74 8830 57 el el NNP cord-015021-pol2qm74 8830 58 reported report VBD cord-015021-pol2qm74 8830 59 theh'use theh'use CD cord-015021-pol2qm74 8831 1 In in IN cord-015021-pol2qm74 8831 2 two two CD cord-015021-pol2qm74 8831 3 brothers brother NNS cord-015021-pol2qm74 8831 4 with with IN cord-015021-pol2qm74 8831 5 greater great JJR cord-015021-pol2qm74 8831 6 than than IN cord-015021-pol2qm74 8831 7 90 90 CD cord-015021-pol2qm74 8831 8 % % NN cord-015021-pol2qm74 8831 9 total total JJ cord-015021-pol2qm74 8831 10 body body NN cord-015021-pol2qm74 8831 11 surface surface NN cord-015021-pol2qm74 8831 12 area area NN cord-015021-pol2qm74 8831 13 burn burn VB cord-015021-pol2qm74 8831 14 . . . cord-015021-pol2qm74 8832 1 Unfortunately unfortunately RB cord-015021-pol2qm74 8832 2 , , , cord-015021-pol2qm74 8832 3 CEA CEA NNP cord-015021-pol2qm74 8832 4 take take VB cord-015021-pol2qm74 8832 5 rate rate NN cord-015021-pol2qm74 8832 6 varies vary VBZ cord-015021-pol2qm74 8832 7 widely widely RB cord-015021-pol2qm74 8832 8 and and CC cord-015021-pol2qm74 8832 9 the the DT cord-015021-pol2qm74 8832 10 resultant resultant JJ cord-015021-pol2qm74 8832 11 skin skin NN cord-015021-pol2qm74 8832 12 coverage coverage NN cord-015021-pol2qm74 8832 13 Is be VBZ cord-015021-pol2qm74 8832 14 often often RB cord-015021-pol2qm74 8832 15 fragile fragile JJ cord-015021-pol2qm74 8832 16 and and CC cord-015021-pol2qm74 8832 17 the the DT cord-015021-pol2qm74 8832 18 cosmetic cosmetic JJ cord-015021-pol2qm74 8832 19 results result NNS cord-015021-pol2qm74 8832 20 are be VBP cord-015021-pol2qm74 8832 21 less less JJR cord-015021-pol2qm74 8832 22 than than IN cord-015021-pol2qm74 8832 23 optimal optimal JJ cord-015021-pol2qm74 8833 1 However however RB cord-015021-pol2qm74 8833 2 the the DT cord-015021-pol2qm74 8833 3 overall overall JJ cord-015021-pol2qm74 8833 4 take take NN cord-015021-pol2qm74 8834 1 rate rate NN cord-015021-pol2qm74 8834 2 and and CC cord-015021-pol2qm74 8834 3 durability durability NN cord-015021-pol2qm74 8834 4 of of IN cord-015021-pol2qm74 8834 5 the the DT cord-015021-pol2qm74 8834 6 coveraSe coveraSe NNP cord-015021-pol2qm74 8834 7 can can MD cord-015021-pol2qm74 8834 8 be be VB cord-015021-pol2qm74 8834 9 markedly markedly RB cord-015021-pol2qm74 8834 10 Improved improve VBN cord-015021-pol2qm74 8834 11 by by IN cord-015021-pol2qm74 8834 12 using use VBG cord-015021-pol2qm74 8834 13 nn nn NNP cord-015021-pol2qm74 8834 14 allodermls allodermls NNP cord-015021-pol2qm74 8834 15 base base NN cord-015021-pol2qm74 8834 16 as as IN cord-015021-pol2qm74 8834 17 the the DT cord-015021-pol2qm74 8834 18 recipient recipient NN cord-015021-pol2qm74 8834 19 bed bed NN cord-015021-pol2qm74 8834 20 . . . cord-015021-pol2qm74 8835 1 A a DT cord-015021-pol2qm74 8835 2 review review NN cord-015021-pol2qm74 8835 3 of of IN cord-015021-pol2qm74 8835 4 CEA CEA NNP cord-015021-pol2qm74 8835 5 applications application NNS cord-015021-pol2qm74 8835 6 performed perform VBN cord-015021-pol2qm74 8835 7 by by IN cord-015021-pol2qm74 8835 8 physicians physician NNS cord-015021-pol2qm74 8835 9 using use VBG cord-015021-pol2qm74 8835 10 cultured cultured JJ cord-015021-pol2qm74 8835 11 outologens outologens JJ cord-015021-pol2qm74 8835 12 epithelium epithelium NN cord-015021-pol2qm74 8835 13 obtained obtain VBN cord-015021-pol2qm74 8835 14 from from IN cord-015021-pol2qm74 8835 15 Blusurfaoe Blusurfaoe NNP cord-015021-pol2qm74 8835 16 Teclmology Teclmology NNP cord-015021-pol2qm74 8835 17 , , , cord-015021-pol2qm74 8835 18 Inc. Inc. NNP cord-015021-pol2qm74 8835 19 shows show VBZ cord-015021-pol2qm74 8835 20 a a DT cord-015021-pol2qm74 8835 21 marked marked JJ cord-015021-pol2qm74 8835 22 discrepancy discrepancy NN cord-015021-pol2qm74 8835 23 in in IN cord-015021-pol2qm74 8835 24 the the DT cord-015021-pol2qm74 8835 25 results result NNS cord-015021-pol2qm74 8835 26 obtained obtain VBN cord-015021-pol2qm74 8835 27 utilizing utilize VBG cord-015021-pol2qm74 8835 28 different different JJ cord-015021-pol2qm74 8835 29 methods method NNS cord-015021-pol2qm74 8835 30 of of IN cord-015021-pol2qm74 8835 31 wound wound JJ cord-015021-pol2qm74 8835 32 bed bed NN cord-015021-pol2qm74 8835 33 preparation preparation NN cord-015021-pol2qm74 8835 34 . . . cord-015021-pol2qm74 8836 1 TGF TGF NNP cord-015021-pol2qm74 8836 2 - - HYPH cord-015021-pol2qm74 8836 3 B B NNP cord-015021-pol2qm74 8836 4 is be VBZ cord-015021-pol2qm74 8836 5 an an DT cord-015021-pol2qm74 8836 6 important important JJ cord-015021-pol2qm74 8836 7 modulator modulator NN cord-015021-pol2qm74 8836 8 coordinating coordinate VBG cord-015021-pol2qm74 8836 9 complex complex JJ cord-015021-pol2qm74 8836 10 physiological physiological JJ cord-015021-pol2qm74 8836 11 events event NNS cord-015021-pol2qm74 8836 12 associated associate VBN cord-015021-pol2qm74 8836 13 with with IN cord-015021-pol2qm74 8836 14 growth growth NN cord-015021-pol2qm74 8836 15 and and CC cord-015021-pol2qm74 8836 16 development development NN cord-015021-pol2qm74 8836 17 . . . cord-015021-pol2qm74 8837 1 It -PRON- PRP cord-015021-pol2qm74 8837 2 is be VBZ cord-015021-pol2qm74 8837 3 assumed assume VBN cord-015021-pol2qm74 8837 4 that that IN cord-015021-pol2qm74 8837 5 TGF TGF NNP cord-015021-pol2qm74 8837 6 - - HYPH cord-015021-pol2qm74 8837 7 B B NNP cord-015021-pol2qm74 8837 8 is be VBZ cord-015021-pol2qm74 8837 9 also also RB cord-015021-pol2qm74 8837 10 involved involve VBN cord-015021-pol2qm74 8837 11 in in IN cord-015021-pol2qm74 8837 12 the the DT cord-015021-pol2qm74 8837 13 well well RB cord-015021-pol2qm74 8837 14 - - HYPH cord-015021-pol2qm74 8837 15 coordinated coordinate VBN cord-015021-pol2qm74 8837 16 process process NN cord-015021-pol2qm74 8837 17 of of IN cord-015021-pol2qm74 8837 18 cutaneous cutaneous JJ cord-015021-pol2qm74 8837 19 wound wound NN cord-015021-pol2qm74 8837 20 healing healing NN cord-015021-pol2qm74 8837 21 by by IN cord-015021-pol2qm74 8837 22 regulating regulate VBG cord-015021-pol2qm74 8837 23 proliferation proliferation NN cord-015021-pol2qm74 8837 24 , , , cord-015021-pol2qm74 8837 25 differentiation differentiation NN cord-015021-pol2qm74 8837 26 , , , cord-015021-pol2qm74 8837 27 chemotaxis chemotaxis NN cord-015021-pol2qm74 8837 28 and and CC cord-015021-pol2qm74 8837 29 matrix matrix NN cord-015021-pol2qm74 8837 30 deposition deposition NN cord-015021-pol2qm74 8837 31 . . . cord-015021-pol2qm74 8838 1 The the DT cord-015021-pol2qm74 8838 2 purpose purpose NN cord-015021-pol2qm74 8838 3 of of IN cord-015021-pol2qm74 8838 4 our -PRON- PRP$ cord-015021-pol2qm74 8838 5 study study NN cord-015021-pol2qm74 8838 6 was be VBD cord-015021-pol2qm74 8838 7 to to TO cord-015021-pol2qm74 8838 8 analyze analyze VB cord-015021-pol2qm74 8838 9 the the DT cord-015021-pol2qm74 8838 10 spatial spatial JJ cord-015021-pol2qm74 8838 11 and and CC cord-015021-pol2qm74 8838 12 temporal temporal JJ cord-015021-pol2qm74 8838 13 pattern pattern NN cord-015021-pol2qm74 8838 14 of of IN cord-015021-pol2qm74 8838 15 TGF TGF NNP cord-015021-pol2qm74 8838 16 - - HYPH cord-015021-pol2qm74 8838 17 B b NN cord-015021-pol2qm74 8838 18 expression expression NN cord-015021-pol2qm74 8838 19 during during IN cord-015021-pol2qm74 8838 20 granulation granulation NN cord-015021-pol2qm74 8838 21 tissue tissue NN cord-015021-pol2qm74 8838 22 formation formation NN cord-015021-pol2qm74 8838 23 in in IN cord-015021-pol2qm74 8838 24 patients patient NNS cord-015021-pol2qm74 8838 25 with with IN cord-015021-pol2qm74 8838 26 accidanutl accidanutl NNP cord-015021-pol2qm74 8838 27 surgical surgical JJ cord-015021-pol2qm74 8838 28 trauma trauma NN cord-015021-pol2qm74 8839 1 ( ( -LRB- cord-015021-pol2qm74 8839 2 monotraumata monotraumata NNP cord-015021-pol2qm74 8839 3 mid mid NNP cord-015021-pol2qm74 8839 4 polytraumata polytraumata NNP cord-015021-pol2qm74 8839 5 ) ) -RRB- cord-015021-pol2qm74 8839 6 and and CC cord-015021-pol2qm74 8839 7 bum bum JJ cord-015021-pol2qm74 8839 8 wounds wound NNS cord-015021-pol2qm74 8839 9 . . . cord-015021-pol2qm74 8840 1 After after IN cord-015021-pol2qm74 8840 2 debridement debridement NN cord-015021-pol2qm74 8840 3 ( ( -LRB- cord-015021-pol2qm74 8840 4 day day NN cord-015021-pol2qm74 8840 5 0 0 CD cord-015021-pol2qm74 8840 6 ) ) -RRB- cord-015021-pol2qm74 8840 7 , , , cord-015021-pol2qm74 8840 8 the the DT cord-015021-pol2qm74 8840 9 full full JJ cord-015021-pol2qm74 8840 10 thickness thickness NN cord-015021-pol2qm74 8840 11 wounds wound NNS cord-015021-pol2qm74 8840 12 were be VBD cord-015021-pol2qm74 8840 13 covered cover VBN cord-015021-pol2qm74 8840 14 with with IN cord-015021-pol2qm74 8840 15 Epigard Epigard NNP cord-015021-pol2qm74 8840 16 , , , cord-015021-pol2qm74 8840 17 a a DT cord-015021-pol2qm74 8840 18 synthetic synthetic JJ cord-015021-pol2qm74 8840 19 dressing dressing NN cord-015021-pol2qm74 8840 20 until until IN cord-015021-pol2qm74 8840 21 day day NN cord-015021-pol2qm74 8840 22 10 10 CD cord-015021-pol2qm74 8840 23 . . . cord-015021-pol2qm74 8841 1 After after IN cord-015021-pol2qm74 8841 2 this this DT cord-015021-pol2qm74 8841 3 time time NN cord-015021-pol2qm74 8841 4 the the DT cord-015021-pol2qm74 8841 5 granulated granulated JJ cord-015021-pol2qm74 8841 6 wounds wound NNS cord-015021-pol2qm74 8841 7 were be VBD cord-015021-pol2qm74 8841 8 closed close VBN cord-015021-pol2qm74 8841 9 by by IN cord-015021-pol2qm74 8841 10 transplantation transplantation NN cord-015021-pol2qm74 8841 11 of of IN cord-015021-pol2qm74 8841 12 mesh mesh NN cord-015021-pol2qm74 8841 13 graft graft NN cord-015021-pol2qm74 8841 14 . . . cord-015021-pol2qm74 8842 1 Biopsies biopsy NNS cord-015021-pol2qm74 8842 2 of of IN cord-015021-pol2qm74 8842 3 the the DT cord-015021-pol2qm74 8842 4 wound wound NN cord-015021-pol2qm74 8842 5 center center NN cord-015021-pol2qm74 8842 6 were be VBD cord-015021-pol2qm74 8842 7 taken take VBN cord-015021-pol2qm74 8842 8 from from IN cord-015021-pol2qm74 8842 9 30 30 CD cord-015021-pol2qm74 8842 10 patients patient NNS cord-015021-pol2qm74 8842 11 at at IN cord-015021-pol2qm74 8842 12 the the DT cord-015021-pol2qm74 8842 13 beginning beginning NN cord-015021-pol2qm74 8842 14 of of IN cord-015021-pol2qm74 8842 15 surgical surgical JJ cord-015021-pol2qm74 8842 16 treatment treatment NN cord-015021-pol2qm74 8842 17 ( ( -LRB- cord-015021-pol2qm74 8842 18 day day NN cord-015021-pol2qm74 8842 19 0 0 CD cord-015021-pol2qm74 8842 20 ) ) -RRB- cord-015021-pol2qm74 8842 21 and and CC cord-015021-pol2qm74 8842 22 after after IN cord-015021-pol2qm74 8842 23 3 3 CD cord-015021-pol2qm74 8842 24 , , , cord-015021-pol2qm74 8842 25 6 6 CD cord-015021-pol2qm74 8842 26 , , , cord-015021-pol2qm74 8842 27 and and CC cord-015021-pol2qm74 8842 28 10 10 CD cord-015021-pol2qm74 8842 29 days day NNS cord-015021-pol2qm74 8842 30 . . . cord-015021-pol2qm74 8843 1 Cryosections cryosection NNS cord-015021-pol2qm74 8843 2 were be VBD cord-015021-pol2qm74 8843 3 stained stain VBN cord-015021-pol2qm74 8843 4 with with IN cord-015021-pol2qm74 8843 5 antibodies antibody NNS cord-015021-pol2qm74 8843 6 against against IN cord-015021-pol2qm74 8843 7 TGF TGF NNP cord-015021-pol2qm74 8843 8 - - HYPH cord-015021-pol2qm74 8843 9 fi fi NNP cord-015021-pol2qm74 8843 10 s s NNP cord-015021-pol2qm74 8843 11 using use VBG cord-015021-pol2qm74 8843 12 the the DT cord-015021-pol2qm74 8843 13 APAAP APAAP NNP cord-015021-pol2qm74 8843 14 technique technique NN cord-015021-pol2qm74 8843 15 and and CC cord-015021-pol2qm74 8843 16 -for -for HYPH cord-015021-pol2qm74 8843 17 standard standard JJ cord-015021-pol2qm74 8843 18 histology histology NN cord-015021-pol2qm74 8843 19 -with -with : cord-015021-pol2qm74 8843 20 Hematoxylin Hematoxylin NNP cord-015021-pol2qm74 8843 21 - - HYPH cord-015021-pol2qm74 8843 22 Eosin Eosin NNP cord-015021-pol2qm74 8843 23 . . . cord-015021-pol2qm74 8844 1 For for IN cord-015021-pol2qm74 8844 2 identification identification NN cord-015021-pol2qm74 8844 3 of of IN cord-015021-pol2qm74 8844 4 the the DT cord-015021-pol2qm74 8844 5 cell cell NN cord-015021-pol2qm74 8844 6 type type NN cord-015021-pol2qm74 8844 7 expressing express VBG cord-015021-pol2qm74 8844 8 TGF-6 TGF-6 NNP cord-015021-pol2qm74 8844 9 , , , cord-015021-pol2qm74 8844 10 double double JJ cord-015021-pol2qm74 8844 11 staining staining NN cord-015021-pol2qm74 8844 12 immunofluorescence immunofluorescence NN cord-015021-pol2qm74 8844 13 experiments experiment NNS cord-015021-pol2qm74 8844 14 were be VBD cord-015021-pol2qm74 8844 15 conducted conduct VBN cord-015021-pol2qm74 8844 16 using use VBG cord-015021-pol2qm74 8844 17 antibodies antibody NNS cord-015021-pol2qm74 8844 18 specific specific JJ cord-015021-pol2qm74 8844 19 for for IN cord-015021-pol2qm74 8844 20 monocytes monocyte NNS cord-015021-pol2qm74 8844 21 / / SYM cord-015021-pol2qm74 8844 22 macrophages macrophage NNS cord-015021-pol2qm74 8844 23 , , , cord-015021-pol2qm74 8844 24 polymorphoanclear polymorphoanclear NNP cord-015021-pol2qm74 8844 25 neutropkils neutropkil NNS cord-015021-pol2qm74 8844 26 and and CC cord-015021-pol2qm74 8844 27 fibroblasts fibroblast NNS cord-015021-pol2qm74 8844 28 . . . cord-015021-pol2qm74 8845 1 The the DT cord-015021-pol2qm74 8845 2 results result NNS cord-015021-pol2qm74 8845 3 showed show VBD cord-015021-pol2qm74 8845 4 a a DT cord-015021-pol2qm74 8845 5 characteristic characteristic JJ cord-015021-pol2qm74 8845 6 pattern pattern NN cord-015021-pol2qm74 8845 7 of of IN cord-015021-pol2qm74 8845 8 TGF TGF NNP cord-015021-pol2qm74 8845 9 - - HYPH cord-015021-pol2qm74 8845 10 t~ t~ CD cord-015021-pol2qm74 8845 11 distribution distribution NN cord-015021-pol2qm74 8845 12 during during IN cord-015021-pol2qm74 8845 13 wound wound NN cord-015021-pol2qm74 8845 14 development development NN cord-015021-pol2qm74 8845 15 . . . cord-015021-pol2qm74 8846 1 TGF TGF NNP cord-015021-pol2qm74 8846 2 - - HYPH cord-015021-pol2qm74 8846 3 fi fi NN cord-015021-pol2qm74 8846 4 appearence appearence NN cord-015021-pol2qm74 8846 5 was be VBD cord-015021-pol2qm74 8846 6 mainly mainly RB cord-015021-pol2qm74 8846 7 cell cell NN cord-015021-pol2qm74 8846 8 - - HYPH cord-015021-pol2qm74 8846 9 associated associate VBN cord-015021-pol2qm74 8846 10 znd znd NN cord-015021-pol2qm74 8847 1 the the DT cord-015021-pol2qm74 8847 2 absolute absolute JJ cord-015021-pol2qm74 8847 3 and and CC cord-015021-pol2qm74 8847 4 relative relative JJ cord-015021-pol2qm74 8847 5 number number NN cord-015021-pol2qm74 8847 6 of of IN cord-015021-pol2qm74 8847 7 cells cell NNS cord-015021-pol2qm74 8847 8 that that WDT cord-015021-pol2qm74 8847 9 were be VBD cord-015021-pol2qm74 8847 10 positive positive JJ cord-015021-pol2qm74 8847 11 increased increase VBN cord-015021-pol2qm74 8847 12 with with IN cord-015021-pol2qm74 8847 13 lime lime NN cord-015021-pol2qm74 8847 14 . . . cord-015021-pol2qm74 8848 1 Infiltrating infiltrate VBG cord-015021-pol2qm74 8848 2 cells cell NNS cord-015021-pol2qm74 8848 3 and and CC cord-015021-pol2qm74 8848 4 developing develop VBG cord-015021-pol2qm74 8848 5 blood blood NN cord-015021-pol2qm74 8848 6 vessels vessel NNS cord-015021-pol2qm74 8848 7 were be VBD cord-015021-pol2qm74 8848 8 most most RBS cord-015021-pol2qm74 8848 9 prominently prominently RB cord-015021-pol2qm74 8848 10 stained stain VBN cord-015021-pol2qm74 8848 11 ; ; : cord-015021-pol2qm74 8848 12 epithelial epithelial JJ cord-015021-pol2qm74 8848 13 and and CC cord-015021-pol2qm74 8848 14 T t NN cord-015021-pol2qm74 8848 15 - - HYPH cord-015021-pol2qm74 8848 16 cells cell NNS cord-015021-pol2qm74 8848 17 showed show VBD cord-015021-pol2qm74 8848 18 no no DT cord-015021-pol2qm74 8848 19 immuno immuno JJ cord-015021-pol2qm74 8848 20 - - HYPH cord-015021-pol2qm74 8848 21 reactivity reactivity NN cord-015021-pol2qm74 8848 22 . . . cord-015021-pol2qm74 8849 1 A a DT cord-015021-pol2qm74 8849 2 delay delay NN cord-015021-pol2qm74 8849 3 of of IN cord-015021-pol2qm74 8849 4 emergence emergence NN cord-015021-pol2qm74 8849 5 for for IN cord-015021-pol2qm74 8849 6 TGF TGF NNP cord-015021-pol2qm74 8849 7 - - HYPH cord-015021-pol2qm74 8849 8 B B NNP cord-015021-pol2qm74 8849 9 during during IN cord-015021-pol2qm74 8849 10 the the DT cord-015021-pol2qm74 8849 11 time time NN cord-015021-pol2qm74 8849 12 course course NN cord-015021-pol2qm74 8849 13 could could MD cord-015021-pol2qm74 8849 14 be be VB cord-015021-pol2qm74 8849 15 seen see VBN cord-015021-pol2qm74 8849 16 in in IN cord-015021-pol2qm74 8849 17 one one CD cord-015021-pol2qm74 8849 18 patient patient NN cord-015021-pol2qm74 8849 19 group group NN cord-015021-pol2qm74 8849 20 . . . cord-015021-pol2qm74 8850 1 This this DT cord-015021-pol2qm74 8850 2 might may MD cord-015021-pol2qm74 8850 3 reflect reflect VB cord-015021-pol2qm74 8850 4 various various JJ cord-015021-pol2qm74 8850 5 regulation regulation NN cord-015021-pol2qm74 8850 6 patterns pattern NNS cord-015021-pol2qm74 8850 7 depending depend VBG cord-015021-pol2qm74 8850 8 on on IN cord-015021-pol2qm74 8850 9 the the DT cord-015021-pol2qm74 8850 10 type type NN cord-015021-pol2qm74 8850 11 and and CC cord-015021-pol2qm74 8850 12 severity severity NN cord-015021-pol2qm74 8850 13 of of IN cord-015021-pol2qm74 8850 14 injury.(1 injury.(1 CD cord-015021-pol2qm74 8850 15 ) ) -RRB- cord-015021-pol2qm74 8851 1 PharmaTec PharmaTec NNP cord-015021-pol2qm74 8851 2 GmbH GmbH NNP cord-015021-pol2qm74 8851 3 , , , cord-015021-pol2qm74 8851 4 Frankfurt Frankfurt NNP cord-015021-pol2qm74 8851 5 ( ( -LRB- cord-015021-pol2qm74 8851 6 2 2 CD cord-015021-pol2qm74 8851 7 ) ) -RRB- cord-015021-pol2qm74 8851 8 Institut Institut NNP cord-015021-pol2qm74 8851 9 fiir fiir VBD cord-015021-pol2qm74 8851 10 Immonologie Immonologie NNP cord-015021-pol2qm74 8851 11 and and CC cord-015021-pol2qm74 8851 12 Serologic Serologic NNP cord-015021-pol2qm74 8851 13 , , , cord-015021-pol2qm74 8852 1 Heidelberg Heidelberg NNP cord-015021-pol2qm74 8852 2 ( ( -LRB- cord-015021-pol2qm74 8852 3 Immune Immune NNP cord-015021-pol2qm74 8852 4 cells cell NNS cord-015021-pol2qm74 8852 5 extravasating extravasate VBG cord-015021-pol2qm74 8852 6 specifically specifically RB cord-015021-pol2qm74 8852 7 in in IN cord-015021-pol2qm74 8852 8 skin skin NN cord-015021-pol2qm74 8852 9 recognize recognize VBP cord-015021-pol2qm74 8852 10 and and CC cord-015021-pol2qm74 8852 11 eliminate eliminate VB cord-015021-pol2qm74 8852 12 the the DT cord-015021-pol2qm74 8852 13 invading invade VBG cord-015021-pol2qm74 8852 14 antigens antigen NNS cord-015021-pol2qm74 8852 15 ( ( -LRB- cord-015021-pol2qm74 8852 16 bacteria bacteria NNS cord-015021-pol2qm74 8852 17 , , , cord-015021-pol2qm74 8852 18 viruses virus NNS cord-015021-pol2qm74 8852 19 , , , cord-015021-pol2qm74 8852 20 etc etc FW cord-015021-pol2qm74 8852 21 . . . cord-015021-pol2qm74 8852 22 ) ) -RRB- cord-015021-pol2qm74 8853 1 either either CC cord-015021-pol2qm74 8853 2 in in IN cord-015021-pol2qm74 8853 3 situ situ NN cord-015021-pol2qm74 8853 4 or or CC cord-015021-pol2qm74 8853 5 transport transport VB cord-015021-pol2qm74 8853 6 them -PRON- PRP cord-015021-pol2qm74 8853 7 to to IN cord-015021-pol2qm74 8853 8 regional regional JJ cord-015021-pol2qm74 8853 9 lymph lymph NN cord-015021-pol2qm74 8853 10 nodes node NNS cord-015021-pol2qm74 8853 11 . . . cord-015021-pol2qm74 8854 1 They -PRON- PRP cord-015021-pol2qm74 8854 2 also also RB cord-015021-pol2qm74 8854 3 participate participate VBP cord-015021-pol2qm74 8854 4 in in IN cord-015021-pol2qm74 8854 5 the the DT cord-015021-pol2qm74 8854 6 process process NN cord-015021-pol2qm74 8854 7 of of IN cord-015021-pol2qm74 8854 8 skin skin NN cord-015021-pol2qm74 8854 9 wound wound NN cord-015021-pol2qm74 8854 10 healing healing NN cord-015021-pol2qm74 8854 11 . . . cord-015021-pol2qm74 8855 1 Cells cell NNS cord-015021-pol2qm74 8855 2 which which WDT cord-015021-pol2qm74 8855 3 traffic traffic NN cord-015021-pol2qm74 8855 4 through through IN cord-015021-pol2qm74 8855 5 the the DT cord-015021-pol2qm74 8855 6 skin skin NN cord-015021-pol2qm74 8855 7 can can MD cord-015021-pol2qm74 8855 8 be be VB cord-015021-pol2qm74 8855 9 harvested harvest VBN cord-015021-pol2qm74 8855 10 from from IN cord-015021-pol2qm74 8855 11 efferent efferent JJ cord-015021-pol2qm74 8855 12 lymph lymph NNS cord-015021-pol2qm74 8855 13 drained drain VBN cord-015021-pol2qm74 8855 14 from from IN cord-015021-pol2qm74 8855 15 a a DT cord-015021-pol2qm74 8855 16 given give VBN cord-015021-pol2qm74 8855 17 area area NN cord-015021-pol2qm74 8855 18 of of IN cord-015021-pol2qm74 8855 19 skin skin NN cord-015021-pol2qm74 8855 20 . . . cord-015021-pol2qm74 8856 1 The the DT cord-015021-pol2qm74 8856 2 type type NN cord-015021-pol2qm74 8856 3 of of IN cord-015021-pol2qm74 8856 4 migrating migrate VBG cord-015021-pol2qm74 8856 5 cells cell NNS cord-015021-pol2qm74 8856 6 changes change NNS cord-015021-pol2qm74 8856 7 after after IN cord-015021-pol2qm74 8856 8 trauma trauma NN cord-015021-pol2qm74 8856 9 , , , cord-015021-pol2qm74 8856 10 heating heating NN cord-015021-pol2qm74 8856 11 and and CC cord-015021-pol2qm74 8856 12 infection infection NN cord-015021-pol2qm74 8856 13 . . . cord-015021-pol2qm74 8857 1 We -PRON- PRP cord-015021-pol2qm74 8857 2 have have VBP cord-015021-pol2qm74 8857 3 developed develop VBN cord-015021-pol2qm74 8857 4 a a DT cord-015021-pol2qm74 8857 5 method method NN cord-015021-pol2qm74 8857 6 for for IN cord-015021-pol2qm74 8857 7 collection collection NN cord-015021-pol2qm74 8857 8 of of IN cord-015021-pol2qm74 8857 9 human human JJ cord-015021-pol2qm74 8857 10 afferent afferent JJ cord-015021-pol2qm74 8857 11 lymph lymph NN cord-015021-pol2qm74 8857 12 in in IN cord-015021-pol2qm74 8857 13 lower low JJR cord-015021-pol2qm74 8857 14 limbs limb NNS cord-015021-pol2qm74 8857 15 . . . cord-015021-pol2qm74 8858 1 The the DT cord-015021-pol2qm74 8858 2 method method NN cord-015021-pol2qm74 8858 3 allows allow VBZ cord-015021-pol2qm74 8858 4 obtaining obtain VBG cord-015021-pol2qm74 8858 5 immune immune JJ cord-015021-pol2qm74 8858 6 cells cell NNS cord-015021-pol2qm74 8858 7 from from IN cord-015021-pol2qm74 8858 8 normal normal JJ cord-015021-pol2qm74 8858 9 and and CC cord-015021-pol2qm74 8858 10 injured injured JJ cord-015021-pol2qm74 8858 11 skin skin NN cord-015021-pol2qm74 8858 12 and and CC cord-015021-pol2qm74 8858 13 their -PRON- PRP$ cord-015021-pol2qm74 8858 14 characterization characterization NN cord-015021-pol2qm74 8858 15 . . . cord-015021-pol2qm74 8859 1 AIM aim VB cord-015021-pol2qm74 8859 2 OF of IN cord-015021-pol2qm74 8859 3 THE the DT cord-015021-pol2qm74 8859 4 STUDY study NN cord-015021-pol2qm74 8859 5 was be VBD cord-015021-pol2qm74 8859 6 to to TO cord-015021-pol2qm74 8859 7 characterize characterize VB cord-015021-pol2qm74 8859 8 skin skin NN cord-015021-pol2qm74 8859 9 immune immune JJ cord-015021-pol2qm74 8859 10 cells cell NNS cord-015021-pol2qm74 8859 11 in in IN cord-015021-pol2qm74 8859 12 situ situ NN cord-015021-pol2qm74 8859 13 and and CC cord-015021-pol2qm74 8859 14 in in IN cord-015021-pol2qm74 8859 15 skin skin NN cord-015021-pol2qm74 8859 16 lymph lymph NN cord-015021-pol2qm74 8859 17 with with IN cord-015021-pol2qm74 8859 18 use use NN cord-015021-pol2qm74 8859 19 of of IN cord-015021-pol2qm74 8859 20 immunohistological immunohistological JJ cord-015021-pol2qm74 8859 21 methods method NNS cord-015021-pol2qm74 8859 22 ( ( -LRB- cord-015021-pol2qm74 8859 23 staining stain VBG cord-015021-pol2qm74 8859 24 , , , cord-015021-pol2qm74 8859 25 FACS FACS NNP cord-015021-pol2qm74 8859 26 ) ) -RRB- cord-015021-pol2qm74 8859 27 . . . cord-015021-pol2qm74 8860 1 RESULTS result NNS cord-015021-pol2qm74 8860 2 . . . cord-015021-pol2qm74 8861 1 Group group NN cord-015021-pol2qm74 8861 2 1 1 CD cord-015021-pol2qm74 8861 3 , , , cord-015021-pol2qm74 8861 4 cells cell NNS cord-015021-pol2qm74 8861 5 migrating migrate VBG cord-015021-pol2qm74 8861 6 through through IN cord-015021-pol2qm74 8861 7 skin skin NN cord-015021-pol2qm74 8861 8 : : : cord-015021-pol2qm74 8861 9 75 75 CD cord-015021-pol2qm74 8861 10 + + SYM cord-015021-pol2qm74 8861 11 4 4 CD cord-015021-pol2qm74 8861 12 % % NN cord-015021-pol2qm74 8861 13 T t NN cord-015021-pol2qm74 8861 14 lymphocytes lymphocyte NNS cord-015021-pol2qm74 8861 15 ( ( -LRB- cord-015021-pol2qm74 8861 16 CD3 CD3 NNP cord-015021-pol2qm74 8861 17 ) ) -RRB- cord-015021-pol2qm74 8861 18 , , , cord-015021-pol2qm74 8861 19 6 6 CD cord-015021-pol2qm74 8861 20 + + SYM cord-015021-pol2qm74 8861 21 3 3 CD cord-015021-pol2qm74 8861 22 % % NN cord-015021-pol2qm74 8861 23 Langerhans langerhan NNS cord-015021-pol2qm74 8861 24 and and CC cord-015021-pol2qm74 8861 25 dendritic dendritic JJ cord-015021-pol2qm74 8861 26 cells cell NNS cord-015021-pol2qm74 8861 27 ( ( -LRB- cord-015021-pol2qm74 8861 28 CDla CDla NNP cord-015021-pol2qm74 8861 29 , , , cord-015021-pol2qm74 8861 30 HLA HLA NNP cord-015021-pol2qm74 8861 31 DR DR NNP cord-015021-pol2qm74 8861 32 , , , cord-015021-pol2qm74 8861 33 S100 S100 NNP cord-015021-pol2qm74 8861 34 ) ) -RRB- cord-015021-pol2qm74 8861 35 , , . cord-015021-pol2qm74 8862 1 41 41 CD cord-015021-pol2qm74 8862 2 + + SYM cord-015021-pol2qm74 8862 3 9 9 CD cord-015021-pol2qm74 8862 4 % % NN cord-015021-pol2qm74 8862 5 CD4 CD4 NNP cord-015021-pol2qm74 8862 6 , , , cord-015021-pol2qm74 8862 7 18 18 CD cord-015021-pol2qm74 8862 8 + + SYM cord-015021-pol2qm74 8862 9 6 6 CD cord-015021-pol2qm74 8862 10 % % NN cord-015021-pol2qm74 8862 11 CD8 CD8 NNP cord-015021-pol2qm74 8862 12 , , , cord-015021-pol2qm74 8862 13 no no DT cord-015021-pol2qm74 8862 14 B b NN cord-015021-pol2qm74 8862 15 cells cell NNS cord-015021-pol2qm74 8862 16 ( ( -LRB- cord-015021-pol2qm74 8862 17 CD22 CD22 NNP cord-015021-pol2qm74 8862 18 , , , cord-015021-pol2qm74 8862 19 23 23 CD cord-015021-pol2qm74 8862 20 ) ) -RRB- cord-015021-pol2qm74 8862 21 , , , cord-015021-pol2qm74 8862 22 74 74 CD cord-015021-pol2qm74 8862 23 % % NN cord-015021-pol2qm74 8862 24 CD45R0 cd45r0 NN cord-015021-pol2qm74 8862 25 ( ( -LRB- cord-015021-pol2qm74 8862 26 memory memory NN cord-015021-pol2qm74 8862 27 cells cell NNS cord-015021-pol2qm74 8862 28 ) ) -RRB- cord-015021-pol2qm74 8862 29 , , , cord-015021-pol2qm74 8862 30 6 6 CD cord-015021-pol2qm74 8862 31 + + SYM cord-015021-pol2qm74 8862 32 3 3 CD cord-015021-pol2qm74 8862 33 % % NN cord-015021-pol2qm74 8863 1 IL2R. IL2R. NNP cord-015021-pol2qm74 8863 2 Approximately approximately RB cord-015021-pol2qm74 8863 3 90 90 CD cord-015021-pol2qm74 8863 4 % % NN cord-015021-pol2qm74 8863 5 cells cell NNS cord-015021-pol2qm74 8863 6 possessed possess VBD cord-015021-pol2qm74 8863 7 CDlla CDlla NNPS cord-015021-pol2qm74 8863 8 and and CC cord-015021-pol2qm74 8863 9 18 18 CD cord-015021-pol2qm74 8863 10 antigens antigen NNS cord-015021-pol2qm74 8863 11 . . . cord-015021-pol2qm74 8864 1 CD1 CD1 NNP cord-015021-pol2qm74 8864 2 lc lc NNP cord-015021-pol2qm74 8864 3 was be VBD cord-015021-pol2qm74 8864 4 expressed express VBN cord-015021-pol2qm74 8864 5 only only RB cord-015021-pol2qm74 8864 6 on on IN cord-015021-pol2qm74 8864 7 large large JJ cord-015021-pol2qm74 8864 8 cells cell NNS cord-015021-pol2qm74 8864 9 . . . cord-015021-pol2qm74 8865 1 The the DT cord-015021-pol2qm74 8865 2 frequency frequency NN cord-015021-pol2qm74 8865 3 of of IN cord-015021-pol2qm74 8865 4 all all DT cord-015021-pol2qm74 8865 5 phenotypes phenotype NNS cord-015021-pol2qm74 8865 6 was be VBD cord-015021-pol2qm74 8865 7 different different JJ cord-015021-pol2qm74 8865 8 from from IN cord-015021-pol2qm74 8865 9 the the DT cord-015021-pol2qm74 8865 10 blood blood NN cord-015021-pol2qm74 8865 11 populations population NNS cord-015021-pol2qm74 8865 12 . . . cord-015021-pol2qm74 8866 1 Group group NN cord-015021-pol2qm74 8866 2 2 2 CD cord-015021-pol2qm74 8866 3 , , , cord-015021-pol2qm74 8866 4 cells cell NNS cord-015021-pol2qm74 8866 5 in in IN cord-015021-pol2qm74 8866 6 skin skin NN cord-015021-pol2qm74 8866 7 : : : cord-015021-pol2qm74 8867 1 Langerhans Langerhans NNP cord-015021-pol2qm74 8867 2 cells cell NNS cord-015021-pol2qm74 8867 3 were be VBD cord-015021-pol2qm74 8867 4 found find VBN cord-015021-pol2qm74 8867 5 only only RB cord-015021-pol2qm74 8867 6 in in IN cord-015021-pol2qm74 8867 7 epidermis epidermis NN cord-015021-pol2qm74 8867 8 , , , cord-015021-pol2qm74 8867 9 CD3,4 CD3,4 NNP cord-015021-pol2qm74 8867 10 and and CC cord-015021-pol2qm74 8867 11 8 8 CD cord-015021-pol2qm74 8867 12 , , , cord-015021-pol2qm74 8867 13 CD45R0 cd45r0 NN cord-015021-pol2qm74 8867 14 , , , cord-015021-pol2qm74 8867 15 RB RB NNP cord-015021-pol2qm74 8867 16 , , , cord-015021-pol2qm74 8867 17 ila/18 ila/18 NNP cord-015021-pol2qm74 8867 18 cells cell NNS cord-015021-pol2qm74 8867 19 around around IN cord-015021-pol2qm74 8867 20 venules venule NNS cord-015021-pol2qm74 8867 21 , , , cord-015021-pol2qm74 8867 22 CD68 CD68 NNP cord-015021-pol2qm74 8867 23 ( ( -LRB- cord-015021-pol2qm74 8867 24 macrophages macrophage NNS cord-015021-pol2qm74 8867 25 ) ) -RRB- cord-015021-pol2qm74 8867 26 uniformly uniformly RB cord-015021-pol2qm74 8867 27 dispersed disperse VBN cord-015021-pol2qm74 8867 28 , , , cord-015021-pol2qm74 8867 29 no no UH cord-015021-pol2qm74 8867 30 IL2R il2r NN cord-015021-pol2qm74 8867 31 and and CC cord-015021-pol2qm74 8867 32 B b NN cord-015021-pol2qm74 8867 33 cells cell NNS cord-015021-pol2qm74 8867 34 . . . cord-015021-pol2qm74 8868 1 HLA HLA NNP cord-015021-pol2qm74 8868 2 DR DR NNP cord-015021-pol2qm74 8868 3 positive positive JJ cord-015021-pol2qm74 8868 4 were be VBD cord-015021-pol2qm74 8868 5 endothelial endothelial JJ cord-015021-pol2qm74 8868 6 and and CC cord-015021-pol2qm74 8868 7 some some DT cord-015021-pol2qm74 8868 8 dispersed disperse VBN cord-015021-pol2qm74 8868 9 mononuclear mononuclear JJ cord-015021-pol2qm74 8868 10 cells cell NNS cord-015021-pol2qm74 8868 11 . . . cord-015021-pol2qm74 8869 1 Group group NN cord-015021-pol2qm74 8869 2 3 3 CD cord-015021-pol2qm74 8869 3 , , , cord-015021-pol2qm74 8869 4 one one CD cord-015021-pol2qm74 8869 5 , , , cord-015021-pol2qm74 8869 6 three three CD cord-015021-pol2qm74 8869 7 and and CC cord-015021-pol2qm74 8869 8 thirty thirty CD cord-015021-pol2qm74 8869 9 days day NNS cord-015021-pol2qm74 8869 10 after after IN cord-015021-pol2qm74 8869 11 surgical surgical JJ cord-015021-pol2qm74 8869 12 wound wound NN cord-015021-pol2qm74 8869 13 ( ( -LRB- cord-015021-pol2qm74 8869 14 simple simple JJ cord-015021-pol2qm74 8869 15 varicous varicous JJ cord-015021-pol2qm74 8869 16 vein vein NN cord-015021-pol2qm74 8869 17 extirpation extirpation NN cord-015021-pol2qm74 8869 18 ) ) -RRB- cord-015021-pol2qm74 8869 19 : : : cord-015021-pol2qm74 8869 20 high high JJ cord-015021-pol2qm74 8869 21 density density NN cord-015021-pol2qm74 8869 22 of of IN cord-015021-pol2qm74 8869 23 epidermal epidermal JJ cord-015021-pol2qm74 8869 24 Langerhans Langerhans NNP cord-015021-pol2qm74 8869 25 cells cell NNS cord-015021-pol2qm74 8869 26 , , , cord-015021-pol2qm74 8869 27 HLA HLA NNP cord-015021-pol2qm74 8869 28 DR DR NNP cord-015021-pol2qm74 8869 29 positive positive JJ cord-015021-pol2qm74 8869 30 keratinocytes keratinocyte NNS cord-015021-pol2qm74 8869 31 and and CC cord-015021-pol2qm74 8869 32 all all DT cord-015021-pol2qm74 8869 33 endothelial endothelial JJ cord-015021-pol2qm74 8869 34 ceils ceil NNS cord-015021-pol2qm74 8869 35 , , , cord-015021-pol2qm74 8869 36 few few JJ cord-015021-pol2qm74 8869 37 IL2R IL2R NNS cord-015021-pol2qm74 8869 38 cells cell NNS cord-015021-pol2qm74 8869 39 , , , cord-015021-pol2qm74 8869 40 perivenular perivenular NNP cord-015021-pol2qm74 8869 41 infiltrates infiltrate VBZ cord-015021-pol2qm74 8869 42 of of IN cord-015021-pol2qm74 8869 43 CD68 CD68 NNP cord-015021-pol2qm74 8869 44 , , , cord-015021-pol2qm74 8869 45 45R0 45r0 CD cord-015021-pol2qm74 8869 46 but but CC cord-015021-pol2qm74 8869 47 less less JJR cord-015021-pol2qm74 8869 48 CD3 cd3 NN cord-015021-pol2qm74 8869 49 cells cell NNS cord-015021-pol2qm74 8869 50 , , , cord-015021-pol2qm74 8869 51 high high JJ cord-015021-pol2qm74 8869 52 density density NN cord-015021-pol2qm74 8869 53 of of IN cord-015021-pol2qm74 8869 54 CDlla/18 CDlla/18 NNP cord-015021-pol2qm74 8869 55 cells cell NNS cord-015021-pol2qm74 8869 56 . . . cord-015021-pol2qm74 8870 1 Classic classic JJ cord-015021-pol2qm74 8870 2 staining staining NN cord-015021-pol2qm74 8870 3 of of IN cord-015021-pol2qm74 8870 4 isolated isolated JJ cord-015021-pol2qm74 8870 5 and and CC cord-015021-pol2qm74 8870 6 in in IN cord-015021-pol2qm74 8870 7 situ situ FW cord-015021-pol2qm74 8870 8 located locate VBN cord-015021-pol2qm74 8870 9 ccl!s ccl!s NNP cord-015021-pol2qm74 8870 10 with with IN cord-015021-pol2qm74 8870 11 MGG MGG NNP cord-015021-pol2qm74 8870 12 or or CC cord-015021-pol2qm74 8870 13 HE HE NNP cord-015021-pol2qm74 8870 14 did do VBD cord-015021-pol2qm74 8870 15 not not RB cord-015021-pol2qm74 8870 16 allow allow VB cord-015021-pol2qm74 8870 17 to to TO cord-015021-pol2qm74 8870 18 follow follow VB cord-015021-pol2qm74 8870 19 kinetics kinetic NNS cord-015021-pol2qm74 8870 20 of of IN cord-015021-pol2qm74 8870 21 changes change NNS cord-015021-pol2qm74 8870 22 . . . cord-015021-pol2qm74 8871 1 CONCLUSIONS conclusion NNS cord-015021-pol2qm74 8871 2 . . . cord-015021-pol2qm74 8872 1 This this DT cord-015021-pol2qm74 8872 2 study study NN cord-015021-pol2qm74 8872 3 presents present VBZ cord-015021-pol2qm74 8872 4 the the DT cord-015021-pol2qm74 8872 5 first first JJ cord-015021-pol2qm74 8872 6 in in IN cord-015021-pol2qm74 8872 7 the the DT cord-015021-pol2qm74 8872 8 literature literature NN cord-015021-pol2qm74 8872 9 quantitative quantitative JJ cord-015021-pol2qm74 8872 10 data datum NNS cord-015021-pol2qm74 8872 11 of of IN cord-015021-pol2qm74 8872 12 immune immune JJ cord-015021-pol2qm74 8872 13 cell cell NN cord-015021-pol2qm74 8872 14 traffic traffic NN cord-015021-pol2qm74 8872 15 through through IN cord-015021-pol2qm74 8872 16 normal normal JJ cord-015021-pol2qm74 8872 17 and and CC cord-015021-pol2qm74 8872 18 injured injured JJ cord-015021-pol2qm74 8872 19 human human JJ cord-015021-pol2qm74 8872 20 skin skin NN cord-015021-pol2qm74 8872 21 . . . cord-015021-pol2qm74 8873 1 IN in IN cord-015021-pol2qm74 8873 2 THE the DT cord-015021-pol2qm74 8873 3 _SP cord-015021-pol2qm74 8873 4 CONTROLLED CONTROLLED NNP cord-015021-pol2qm74 8873 5 _SP cord-015021-pol2qm74 8873 6 RELEASE RELEASE VBN cord-015021-pol2qm74 8873 7 _SP cord-015021-pol2qm74 8873 8 OF of IN cord-015021-pol2qm74 8873 9 _SP cord-015021-pol2qm74 8873 10 BIOLOGICAL BIOLOGICAL NNP cord-015021-pol2qm74 8873 11 _SP cord-015021-pol2qm74 8873 12 RESPONSE response NN cord-015021-pol2qm74 8873 13 _SP cord-015021-pol2qm74 8873 14 MODIFIERS modifier NNS cord-015021-pol2qm74 8873 15 FOR for IN cord-015021-pol2qm74 8873 16 SOFT soft JJ cord-015021-pol2qm74 8873 17 TISSUE tissue NN cord-015021-pol2qm74 8873 18 REGENERATION regeneration NN cord-015021-pol2qm74 8873 19 . . . cord-015021-pol2qm74 8874 1 Alan Alan NNP cord-015021-pol2qm74 8874 2 S. S. NNP cord-015021-pol2qm74 8874 3 Rudolph Rudolph NNP cord-015021-pol2qm74 8874 4 , , , cord-015021-pol2qm74 8874 5 Helmut Helmut NNP cord-015021-pol2qm74 8874 6 Speilberg Speilberg NNP cord-015021-pol2qm74 8874 7 , , , cord-015021-pol2qm74 8874 8 Mariam Mariam NNP cord-015021-pol2qm74 8874 9 Monshipouri Monshipouri NNP cord-015021-pol2qm74 8874 10 , , , cord-015021-pol2qm74 8874 11 and and CC cord-015021-pol2qm74 8874 12 Florence Florence NNP cord-015021-pol2qm74 8874 13 Rollwagen Rollwagen NNP cord-015021-pol2qm74 8874 14 , , , cord-015021-pol2qm74 8874 15 and and CC cord-015021-pol2qm74 8874 16 Barry Barry NNP cord-015021-pol2qm74 8874 17 J. J. NNP cord-015021-pol2qm74 8874 18 Spargo Spargo NNP cord-015021-pol2qm74 8874 19 . . . cord-015021-pol2qm74 8875 1 We -PRON- PRP cord-015021-pol2qm74 8875 2 have have VBP cord-015021-pol2qm74 8875 3 employed employ VBN cord-015021-pol2qm74 8875 4 lipid lipid NN cord-015021-pol2qm74 8875 5 microstructures microstructure NNS cord-015021-pol2qm74 8875 6 as as IN cord-015021-pol2qm74 8875 7 controlled control VBN cord-015021-pol2qm74 8875 8 release release NN cord-015021-pol2qm74 8875 9 vehicles vehicle NNS cord-015021-pol2qm74 8875 10 for for IN cord-015021-pol2qm74 8875 11 the the DT cord-015021-pol2qm74 8875 12 delivery delivery NN cord-015021-pol2qm74 8875 13 of of IN cord-015021-pol2qm74 8875 14 growth growth NN cord-015021-pol2qm74 8875 15 factors factor NNS cord-015021-pol2qm74 8875 16 in in IN cord-015021-pol2qm74 8875 17 wound wound NN cord-015021-pol2qm74 8875 18 repair repair NN cord-015021-pol2qm74 8875 19 . . . cord-015021-pol2qm74 8876 1 Traditional traditional JJ cord-015021-pol2qm74 8876 2 liposomes liposome NNS cord-015021-pol2qm74 8876 3 as as RB cord-015021-pol2qm74 8876 4 well well RB cord-015021-pol2qm74 8876 5 as as IN cord-015021-pol2qm74 8876 6 novel novel JJ cord-015021-pol2qm74 8876 7 lipid lipid NN cord-015021-pol2qm74 8876 8 based base VBN cord-015021-pol2qm74 8876 9 microcylinders microcylinder NNS cord-015021-pol2qm74 8876 10 have have VBP cord-015021-pol2qm74 8876 11 been be VBN cord-015021-pol2qm74 8876 12 examined examine VBN cord-015021-pol2qm74 8876 13 for for IN cord-015021-pol2qm74 8876 14 their -PRON- PRP$ cord-015021-pol2qm74 8876 15 in in FW cord-015021-pol2qm74 8876 16 vitro vitro FW cord-015021-pol2qm74 8876 17 kinetics kinetic NNS cord-015021-pol2qm74 8876 18 of of IN cord-015021-pol2qm74 8876 19 the the DT cord-015021-pol2qm74 8876 20 release release NN cord-015021-pol2qm74 8876 21 of of IN cord-015021-pol2qm74 8876 22 transforming transform VBG cord-015021-pol2qm74 8876 23 growth growth NN cord-015021-pol2qm74 8876 24 factor factor NN cord-015021-pol2qm74 8876 25 beta beta NN cord-015021-pol2qm74 8876 26 ( ( -LRB- cord-015021-pol2qm74 8876 27 TGF TGF NNP cord-015021-pol2qm74 8876 28 - - HYPH cord-015021-pol2qm74 8876 29 b b NN cord-015021-pol2qm74 8876 30 ) ) -RRB- cord-015021-pol2qm74 8876 31 . . . cord-015021-pol2qm74 8877 1 In in IN cord-015021-pol2qm74 8877 2 vitro vitro FW cord-015021-pol2qm74 8877 3 reiease reiease NN cord-015021-pol2qm74 8877 4 has have VBZ cord-015021-pol2qm74 8877 5 been be VBN cord-015021-pol2qm74 8877 6 examined examine VBN cord-015021-pol2qm74 8877 7 by by IN cord-015021-pol2qm74 8877 8 setting set VBG cord-015021-pol2qm74 8877 9 up up RP cord-015021-pol2qm74 8877 10 models model NNS cord-015021-pol2qm74 8877 11 with with IN cord-015021-pol2qm74 8877 12 examine examine VB cord-015021-pol2qm74 8877 13 the the DT cord-015021-pol2qm74 8877 14 physical physical JJ cord-015021-pol2qm74 8877 15 release release NN cord-015021-pol2qm74 8877 16 of of IN cord-015021-pol2qm74 8877 17 iodinated iodinate VBN cord-015021-pol2qm74 8877 18 TGF TGF NNP cord-015021-pol2qm74 8877 19 - - HYPH cord-015021-pol2qm74 8877 20 b b NNP cord-015021-pol2qm74 8877 21 as as RB cord-015021-pol2qm74 8877 22 well well RB cord-015021-pol2qm74 8877 23 as as IN cord-015021-pol2qm74 8877 24 a a DT cord-015021-pol2qm74 8877 25 cell cell NN cord-015021-pol2qm74 8877 26 based base VBN cord-015021-pol2qm74 8877 27 bioassay bioassay NN cord-015021-pol2qm74 8877 28 ( ( -LRB- cord-015021-pol2qm74 8877 29 based base VBN cord-015021-pol2qm74 8877 30 on on IN cord-015021-pol2qm74 8877 31 the the DT cord-015021-pol2qm74 8877 32 HT3 ht3 JJ cord-015021-pol2qm74 8877 33 bioassay bioassay NN cord-015021-pol2qm74 8877 34 ) ) -RRB- cord-015021-pol2qm74 8877 35 . . . cord-015021-pol2qm74 8878 1 The the DT cord-015021-pol2qm74 8878 2 hollow hollow JJ cord-015021-pol2qm74 8878 3 lipid lipid NN cord-015021-pol2qm74 8878 4 microcylinders microcylinder NNS cord-015021-pol2qm74 8878 5 ( ( -LRB- cord-015021-pol2qm74 8878 6 50 50 CD cord-015021-pol2qm74 8878 7 microns micron NNS cord-015021-pol2qm74 8878 8 in in IN cord-015021-pol2qm74 8878 9 length length NN cord-015021-pol2qm74 8879 1 and and CC cord-015021-pol2qm74 8879 2 I -PRON- PRP cord-015021-pol2qm74 8879 3 micron micron VBP cord-015021-pol2qm74 8879 4 in in IN cord-015021-pol2qm74 8879 5 diameter diameter NN cord-015021-pol2qm74 8879 6 ) ) -RRB- cord-015021-pol2qm74 8880 1 show show VB cord-015021-pol2qm74 8880 2 an an DT cord-015021-pol2qm74 8880 3 initial initial JJ cord-015021-pol2qm74 8880 4 burst burst NN cord-015021-pol2qm74 8880 5 ( ( -LRB- cord-015021-pol2qm74 8880 6 5 5 CD cord-015021-pol2qm74 8880 7 - - SYM cord-015021-pol2qm74 8880 8 10 10 CD cord-015021-pol2qm74 8880 9 ng ng NN cord-015021-pol2qm74 8880 10 ) ) -RRB- cord-015021-pol2qm74 8880 11 followed follow VBD cord-015021-pol2qm74 8880 12 be be VB cord-015021-pol2qm74 8880 13 zero zero CD cord-015021-pol2qm74 8880 14 order order NN cord-015021-pol2qm74 8880 15 kinetics kinetics NN cord-015021-pol2qm74 8880 16 which which WDT cord-015021-pol2qm74 8880 17 result result VBP cord-015021-pol2qm74 8880 18 in in IN cord-015021-pol2qm74 8880 19 the the DT cord-015021-pol2qm74 8880 20 release release NN cord-015021-pol2qm74 8880 21 of of IN cord-015021-pol2qm74 8880 22 approximately approximately RB cord-015021-pol2qm74 8880 23 I -PRON- PRP cord-015021-pol2qm74 8880 24 ng ng NNP cord-015021-pol2qm74 8880 25 TGF TGF NNP cord-015021-pol2qm74 8880 26 / / SYM cord-015021-pol2qm74 8880 27 day day NN cord-015021-pol2qm74 8880 28 . . . cord-015021-pol2qm74 8881 1 This this DT cord-015021-pol2qm74 8881 2 release release NN cord-015021-pol2qm74 8881 3 behavior behavior NN cord-015021-pol2qm74 8881 4 can can MD cord-015021-pol2qm74 8881 5 be be VB cord-015021-pol2qm74 8881 6 modified modify VBN cord-015021-pol2qm74 8881 7 by by IN cord-015021-pol2qm74 8881 8 temperature temperature NN cord-015021-pol2qm74 8881 9 based base VBN cord-015021-pol2qm74 8881 10 on on IN cord-015021-pol2qm74 8881 11 the the DT cord-015021-pol2qm74 8881 12 phase phase NN cord-015021-pol2qm74 8881 13 behavior behavior NN cord-015021-pol2qm74 8881 14 of of IN cord-015021-pol2qm74 8881 15 the the DT cord-015021-pol2qm74 8881 16 lipid lipid NN cord-015021-pol2qm74 8881 17 bilayer bilayer NN cord-015021-pol2qm74 8881 18 which which WDT cord-015021-pol2qm74 8881 19 comprises comprise VBZ cord-015021-pol2qm74 8881 20 the the DT cord-015021-pol2qm74 8881 21 microcylinder microcylinder NN cord-015021-pol2qm74 8881 22 . . . cord-015021-pol2qm74 8882 1 We -PRON- PRP cord-015021-pol2qm74 8882 2 have have VBP cord-015021-pol2qm74 8882 3 also also RB cord-015021-pol2qm74 8882 4 examined examine VBN cord-015021-pol2qm74 8882 5 the the DT cord-015021-pol2qm74 8882 6 cellular cellular JJ cord-015021-pol2qm74 8882 7 response response NN cord-015021-pol2qm74 8882 8 to to IN cord-015021-pol2qm74 8882 9 lipid lipid NN cord-015021-pol2qm74 8882 10 microcylinders microcylinder NNS cord-015021-pol2qm74 8882 11 applied apply VBN cord-015021-pol2qm74 8882 12 in in IN cord-015021-pol2qm74 8882 13 vivo vivo NNP cord-015021-pol2qm74 8882 14 . . . cord-015021-pol2qm74 8883 1 The the DT cord-015021-pol2qm74 8883 2 lipid lipid NN cord-015021-pol2qm74 8883 3 microcylinders microcylinder NNS cord-015021-pol2qm74 8883 4 are be VBP cord-015021-pol2qm74 8883 5 mixed mix VBN cord-015021-pol2qm74 8883 6 in in IN cord-015021-pol2qm74 8883 7 agarose agarose JJ cord-015021-pol2qm74 8883 8 and and CC cord-015021-pol2qm74 8883 9 implanted implant VBN cord-015021-pol2qm74 8883 10 as as IN cord-015021-pol2qm74 8883 11 a a DT cord-015021-pol2qm74 8883 12 composite composite JJ cord-015021-pol2qm74 8883 13 hydrogel hydrogel NN cord-015021-pol2qm74 8883 14 block block NN cord-015021-pol2qm74 8883 15 under under IN cord-015021-pol2qm74 8883 16 the the DT cord-015021-pol2qm74 8883 17 flank flank NN cord-015021-pol2qm74 8883 18 of of IN cord-015021-pol2qm74 8883 19 a a DT cord-015021-pol2qm74 8883 20 mouse mouse NN cord-015021-pol2qm74 8883 21 . . . cord-015021-pol2qm74 8884 1 The the DT cord-015021-pol2qm74 8884 2 blocks block NNS cord-015021-pol2qm74 8884 3 are be VBP cord-015021-pol2qm74 8884 4 removed remove VBN cord-015021-pol2qm74 8884 5 1 1 CD cord-015021-pol2qm74 8884 6 , , , cord-015021-pol2qm74 8884 7 3 3 CD cord-015021-pol2qm74 8884 8 , , , cord-015021-pol2qm74 8884 9 and and CC cord-015021-pol2qm74 8884 10 5 5 CD cord-015021-pol2qm74 8884 11 days day NNS cord-015021-pol2qm74 8884 12 following follow VBG cord-015021-pol2qm74 8884 13 implant implant JJ cord-015021-pol2qm74 8884 14 and and CC cord-015021-pol2qm74 8884 15 the the DT cord-015021-pol2qm74 8884 16 cells cell NNS cord-015021-pol2qm74 8884 17 analyzed analyze VBN cord-015021-pol2qm74 8884 18 by by IN cord-015021-pol2qm74 8884 19 FACs FACs NNP cord-015021-pol2qm74 8884 20 sorter sorter NN cord-015021-pol2qm74 8884 21 analysis analysis NN cord-015021-pol2qm74 8884 22 . . . cord-015021-pol2qm74 8885 1 The the DT cord-015021-pol2qm74 8885 2 observed observed JJ cord-015021-pol2qm74 8885 3 pattern pattern NN cord-015021-pol2qm74 8885 4 of of IN cord-015021-pol2qm74 8885 5 ceil ceil NN cord-015021-pol2qm74 8885 6 recruitment recruitment NN cord-015021-pol2qm74 8885 7 to to IN cord-015021-pol2qm74 8885 8 the the DT cord-015021-pol2qm74 8885 9 blocks block NNS cord-015021-pol2qm74 8885 10 mimics mimic VBZ cord-015021-pol2qm74 8885 11 that that WDT cord-015021-pol2qm74 8885 12 seen see VBN cord-015021-pol2qm74 8885 13 in in IN cord-015021-pol2qm74 8885 14 a a DT cord-015021-pol2qm74 8885 15 local local JJ cord-015021-pol2qm74 8885 16 inflammatory inflammatory JJ cord-015021-pol2qm74 8885 17 response response NN cord-015021-pol2qm74 8885 18 . . . cord-015021-pol2qm74 8886 1 Cell cell NN cord-015021-pol2qm74 8886 2 surface surface NN cord-015021-pol2qm74 8886 3 phenotype phenotype NN cord-015021-pol2qm74 8886 4 studies study NNS cord-015021-pol2qm74 8886 5 included include VBD cord-015021-pol2qm74 8886 6 the the DT cord-015021-pol2qm74 8886 7 determination determination NN cord-015021-pol2qm74 8886 8 of of IN cord-015021-pol2qm74 8886 9 CD3 CD3 NNP cord-015021-pol2qm74 8886 10 and and CC cord-015021-pol2qm74 8886 11 CD4 CD4 NNP cord-015021-pol2qm74 8886 12 , , , cord-015021-pol2qm74 8886 13 Mac Mac NNP cord-015021-pol2qm74 8886 14 - - HYPH cord-015021-pol2qm74 8886 15 l l NNP cord-015021-pol2qm74 8886 16 , , , cord-015021-pol2qm74 8886 17 and and CC cord-015021-pol2qm74 8886 18 Ig Ig NNP cord-015021-pol2qm74 8886 19 bearing bearing NN cord-015021-pol2qm74 8886 20 cells cell NNS cord-015021-pol2qm74 8886 21 . . . cord-015021-pol2qm74 8887 1 We -PRON- PRP cord-015021-pol2qm74 8887 2 have have VBP cord-015021-pol2qm74 8887 3 also also RB cord-015021-pol2qm74 8887 4 begun begin VBN cord-015021-pol2qm74 8887 5 to to TO cord-015021-pol2qm74 8887 6 examine examine VB cord-015021-pol2qm74 8887 7 the the DT cord-015021-pol2qm74 8887 8 change change NN cord-015021-pol2qm74 8887 9 in in IN cord-015021-pol2qm74 8887 10 cell cell NN cord-015021-pol2qm74 8887 11 surface surface NN cord-015021-pol2qm74 8887 12 phenotype phenotype NN cord-015021-pol2qm74 8887 13 and and CC cord-015021-pol2qm74 8887 14 kinetics kinetic NNS cord-015021-pol2qm74 8887 15 of of IN cord-015021-pol2qm74 8887 16 recruitment recruitment NN cord-015021-pol2qm74 8887 17 following follow VBG cord-015021-pol2qm74 8887 18 the the DT cord-015021-pol2qm74 8887 19 inclusion inclusion NN cord-015021-pol2qm74 8887 20 of of IN cord-015021-pol2qm74 8887 21 TGF TGF NNP cord-015021-pol2qm74 8887 22 - - HYPH cord-015021-pol2qm74 8887 23 beta beta NN cord-015021-pol2qm74 8887 24 in in IN cord-015021-pol2qm74 8887 25 the the DT cord-015021-pol2qm74 8887 26 lipid lipid NN cord-015021-pol2qm74 8887 27 microcylinders microcylinder NNS cord-015021-pol2qm74 8887 28 . . . cord-015021-pol2qm74 8888 1 Center Center NNP cord-015021-pol2qm74 8888 2 for for IN cord-015021-pol2qm74 8888 3 Biomolecular Biomolecular NNP cord-015021-pol2qm74 8888 4 Science Science NNP cord-015021-pol2qm74 8888 5 and and CC cord-015021-pol2qm74 8888 6 Engineering Engineering NNP cord-015021-pol2qm74 8888 7 , , , cord-015021-pol2qm74 8888 8 Code Code NNP cord-015021-pol2qm74 8888 9 6900 6900 CD cord-015021-pol2qm74 8888 10 , , , cord-015021-pol2qm74 8888 11 Naval Naval NNP cord-015021-pol2qm74 8888 12 Research Research NNP cord-015021-pol2qm74 8888 13 Laboratory Laboratory NNP cord-015021-pol2qm74 8888 14 , , , cord-015021-pol2qm74 8888 15 Washington Washington NNP cord-015021-pol2qm74 8888 16 , , , cord-015021-pol2qm74 8888 17 DC DC NNP cord-015021-pol2qm74 8888 18 . . . cord-015021-pol2qm74 8889 1 20375 20375 CD cord-015021-pol2qm74 8889 2 - - SYM cord-015021-pol2qm74 8889 3 5348 5348 CD cord-015021-pol2qm74 8889 4 . . . cord-015021-pol2qm74 8890 1 Expression expression NN cord-015021-pol2qm74 8890 2 pattern pattern NN cord-015021-pol2qm74 8890 3 of of IN cord-015021-pol2qm74 8890 4 heat heat NN cord-015021-pol2qm74 8890 5 shock shock NN cord-015021-pol2qm74 8890 6 proteins protein NNS cord-015021-pol2qm74 8890 7 in in IN cord-015021-pol2qm74 8890 8 acute acute JJ cord-015021-pol2qm74 8890 9 , , , cord-015021-pol2qm74 8890 10 good good JJ cord-015021-pol2qm74 8890 11 healing healing NN cord-015021-pol2qm74 8890 12 and and CC cord-015021-pol2qm74 8890 13 chronic chronic JJ cord-015021-pol2qm74 8890 14 human human JJ cord-015021-pol2qm74 8890 15 wound wound NN cord-015021-pol2qm74 8890 16 tissue tissue NN cord-015021-pol2qm74 8890 17 . . . cord-015021-pol2qm74 8891 1 Abstract Abstract NNP cord-015021-pol2qm74 8891 2 : : : cord-015021-pol2qm74 8892 1 Wound wound JJ cord-015021-pol2qm74 8892 2 healing healing NN cord-015021-pol2qm74 8892 3 is be VBZ cord-015021-pol2qm74 8892 4 a a DT cord-015021-pol2qm74 8892 5 complex complex JJ cord-015021-pol2qm74 8892 6 biologic biologic JJ cord-015021-pol2qm74 8892 7 process process NN cord-015021-pol2qm74 8892 8 that that WDT cord-015021-pol2qm74 8892 9 is be VBZ cord-015021-pol2qm74 8892 10 well well RB cord-015021-pol2qm74 8892 11 characterized characterize VBN cord-015021-pol2qm74 8892 12 at at IN cord-015021-pol2qm74 8892 13 the the DT cord-015021-pol2qm74 8892 14 histological histological JJ cord-015021-pol2qm74 8892 15 level level NN cord-015021-pol2qm74 8892 16 , , , cord-015021-pol2qm74 8892 17 but but CC cord-015021-pol2qm74 8892 18 its -PRON- PRP$ cord-015021-pol2qm74 8892 19 molecular molecular JJ cord-015021-pol2qm74 8892 20 regulation regulation NN cord-015021-pol2qm74 8892 21 is be VBZ cord-015021-pol2qm74 8892 22 poorly poorly RB cord-015021-pol2qm74 8892 23 understood understand VBN cord-015021-pol2qm74 8892 24 . . . cord-015021-pol2qm74 8893 1 After after IN cord-015021-pol2qm74 8893 2 clot clot NN cord-015021-pol2qm74 8893 3 formation formation NN cord-015021-pol2qm74 8893 4 , , , cord-015021-pol2qm74 8893 5 inflammatory inflammatory JJ cord-015021-pol2qm74 8893 6 cells cell NNS cord-015021-pol2qm74 8893 7 are be VBP cord-015021-pol2qm74 8893 8 rapidly rapidly RB cord-015021-pol2qm74 8893 9 drawn draw VBN cord-015021-pol2qm74 8893 10 into into IN cord-015021-pol2qm74 8893 11 the the DT cord-015021-pol2qm74 8893 12 wound wound NN cord-015021-pol2qm74 8893 13 , , , cord-015021-pol2qm74 8893 14 followed follow VBN cord-015021-pol2qm74 8893 15 by by IN cord-015021-pol2qm74 8893 16 migration migration NN cord-015021-pol2qm74 8893 17 of of IN cord-015021-pol2qm74 8893 18 fibroblasts fibroblast NNS cord-015021-pol2qm74 8893 19 and and CC cord-015021-pol2qm74 8893 20 epithelial epithelial JJ cord-015021-pol2qm74 8893 21 cells cell NNS cord-015021-pol2qm74 8893 22 that that WDT cord-015021-pol2qm74 8893 23 divide divide VBP cord-015021-pol2qm74 8893 24 and and CC cord-015021-pol2qm74 8893 25 repopulate repopulate VB cord-015021-pol2qm74 8893 26 the the DT cord-015021-pol2qm74 8893 27 wound wound NN cord-015021-pol2qm74 8893 28 area area NN cord-015021-pol2qm74 8893 29 . . . cord-015021-pol2qm74 8894 1 During during IN cord-015021-pol2qm74 8894 2 the the DT cord-015021-pol2qm74 8894 3 last last JJ cord-015021-pol2qm74 8894 4 decade decade NN cord-015021-pol2qm74 8894 5 peptide peptide JJ cord-015021-pol2qm74 8894 6 growth growth NN cord-015021-pol2qm74 8894 7 factors factor NNS cord-015021-pol2qm74 8894 8 and and CC cord-015021-pol2qm74 8894 9 cytokine cytokine NN cord-015021-pol2qm74 8894 10 are be VBP cord-015021-pol2qm74 8894 11 thought think VBN cord-015021-pol2qm74 8894 12 to to TO cord-015021-pol2qm74 8894 13 play play VB cord-015021-pol2qm74 8894 14 a a DT cord-015021-pol2qm74 8894 15 key key JJ cord-015021-pol2qm74 8894 16 role role NN cord-015021-pol2qm74 8894 17 in in IN cord-015021-pol2qm74 8894 18 initiating initiate VBG cord-015021-pol2qm74 8894 19 and and CC cord-015021-pol2qm74 8894 20 sustaining sustain VBG cord-015021-pol2qm74 8894 21 the the DT cord-015021-pol2qm74 8894 22 phase phase NN cord-015021-pol2qm74 8894 23 of of IN cord-015021-pol2qm74 8894 24 tissue tissue NN cord-015021-pol2qm74 8894 25 repair repair NN cord-015021-pol2qm74 8894 26 . . . cord-015021-pol2qm74 8895 1 These these DT cord-015021-pol2qm74 8895 2 factors factor NNS cord-015021-pol2qm74 8895 3 which which WDT cord-015021-pol2qm74 8895 4 are be VBP cord-015021-pol2qm74 8895 5 released release VBN cord-015021-pol2qm74 8895 6 from from IN cord-015021-pol2qm74 8895 7 different different JJ cord-015021-pol2qm74 8895 8 cells cell NNS cord-015021-pol2qm74 8895 9 appear appear VBP cord-015021-pol2qm74 8895 10 to to TO cord-015021-pol2qm74 8895 11 initiate initiate VB cord-015021-pol2qm74 8895 12 the the DT cord-015021-pol2qm74 8895 13 cascade cascade NN cord-015021-pol2qm74 8895 14 of of IN cord-015021-pol2qm74 8895 15 events event NNS cord-015021-pol2qm74 8895 16 that that WDT cord-015021-pol2qm74 8895 17 lead lead VBP cord-015021-pol2qm74 8895 18 to to IN cord-015021-pol2qm74 8895 19 healing healing NN cord-015021-pol2qm74 8895 20 . . . cord-015021-pol2qm74 8896 1 Different different JJ cord-015021-pol2qm74 8896 2 studys study NNS cord-015021-pol2qm74 8896 3 described describe VBD cord-015021-pol2qm74 8896 4 the the DT cord-015021-pol2qm74 8896 5 rapid rapid JJ cord-015021-pol2qm74 8896 6 activation activation NN cord-015021-pol2qm74 8896 7 of of IN cord-015021-pol2qm74 8896 8 a a DT cord-015021-pol2qm74 8896 9 family family NN cord-015021-pol2qm74 8896 10 of of IN cord-015021-pol2qm74 8896 11 proteins protein NNS cord-015021-pol2qm74 8896 12 , , , cord-015021-pol2qm74 8896 13 named name VBN cord-015021-pol2qm74 8896 14 heat heat NN cord-015021-pol2qm74 8896 15 shock shock NN cord-015021-pol2qm74 8896 16 proteins protein NNS cord-015021-pol2qm74 8896 17 ( ( -LRB- cord-015021-pol2qm74 8896 18 HSP HSP NNP cord-015021-pol2qm74 8896 19 ) ) -RRB- cord-015021-pol2qm74 8896 20 in in IN cord-015021-pol2qm74 8896 21 differnt differnt NNS cord-015021-pol2qm74 8896 22 tissue tissue NN cord-015021-pol2qm74 8896 23 that that WDT cord-015021-pol2qm74 8896 24 were be VBD cord-015021-pol2qm74 8896 25 exposed expose VBN cord-015021-pol2qm74 8896 26 to to IN cord-015021-pol2qm74 8896 27 various various JJ cord-015021-pol2qm74 8896 28 forms form NNS cord-015021-pol2qm74 8896 29 of of IN cord-015021-pol2qm74 8896 30 stress stress NN cord-015021-pol2qm74 8896 31 ( ( -LRB- cord-015021-pol2qm74 8896 32 heat heat NN cord-015021-pol2qm74 8896 33 , , , cord-015021-pol2qm74 8896 34 toxic toxic JJ cord-015021-pol2qm74 8896 35 agents agent NNS cord-015021-pol2qm74 8896 36 , , , cord-015021-pol2qm74 8896 37 mechanical mechanical JJ cord-015021-pol2qm74 8896 38 ) ) -RRB- cord-015021-pol2qm74 8896 39 . . . cord-015021-pol2qm74 8897 1 In in IN cord-015021-pol2qm74 8897 2 this this DT cord-015021-pol2qm74 8897 3 context context NN cord-015021-pol2qm74 8897 4 HSP HSP NNP cord-015021-pol2qm74 8897 5 's 's POS cord-015021-pol2qm74 8897 6 have have VBP cord-015021-pol2qm74 8897 7 the the DT cord-015021-pol2qm74 8897 8 ability ability NN cord-015021-pol2qm74 8897 9 to to TO cord-015021-pol2qm74 8897 10 regulate regulate VB cord-015021-pol2qm74 8897 11 protein protein NN cord-015021-pol2qm74 8897 12 folding folding NN cord-015021-pol2qm74 8897 13 and and CC cord-015021-pol2qm74 8897 14 assembly assembly NN cord-015021-pol2qm74 8897 15 , , , cord-015021-pol2qm74 8897 16 to to TO cord-015021-pol2qm74 8897 17 transport transport VB cord-015021-pol2qm74 8897 18 proteins protein NNS cord-015021-pol2qm74 8897 19 across across IN cord-015021-pol2qm74 8897 20 cytoplasm cytoplasm NN cord-015021-pol2qm74 8897 21 and and CC cord-015021-pol2qm74 8897 22 membranes membrane NNS cord-015021-pol2qm74 8897 23 , , , cord-015021-pol2qm74 8897 24 to to TO cord-015021-pol2qm74 8897 25 disrupt disrupt VB cord-015021-pol2qm74 8897 26 protein protein NN cord-015021-pol2qm74 8897 27 complexes complex NNS cord-015021-pol2qm74 8897 28 , , , cord-015021-pol2qm74 8897 29 to to TO cord-015021-pol2qm74 8897 30 stabilize stabilize VB cord-015021-pol2qm74 8897 31 , , , cord-015021-pol2qm74 8897 32 degrade degrade VB cord-015021-pol2qm74 8897 33 and and CC cord-015021-pol2qm74 8897 34 regulate regulate VB cord-015021-pol2qm74 8897 35 the the DT cord-015021-pol2qm74 8897 36 synthesis synthesis NN cord-015021-pol2qm74 8897 37 of of IN cord-015021-pol2qm74 8897 38 proteins protein NNS cord-015021-pol2qm74 8897 39 and and CC cord-015021-pol2qm74 8897 40 to to TO cord-015021-pol2qm74 8897 41 take take VB cord-015021-pol2qm74 8897 42 part part NN cord-015021-pol2qm74 8897 43 in in IN cord-015021-pol2qm74 8897 44 DNA dna NN cord-015021-pol2qm74 8897 45 replication replication NN cord-015021-pol2qm74 8897 46 and and CC cord-015021-pol2qm74 8897 47 repair repair NN cord-015021-pol2qm74 8897 48 . . . cord-015021-pol2qm74 8898 1 We -PRON- PRP cord-015021-pol2qm74 8898 2 now now RB cord-015021-pol2qm74 8898 3 attempted attempt VBD cord-015021-pol2qm74 8898 4 to to TO cord-015021-pol2qm74 8898 5 find find VB cord-015021-pol2qm74 8898 6 out out RP cord-015021-pol2qm74 8898 7 if if IN cord-015021-pol2qm74 8898 8 HSP HSP NNP cord-015021-pol2qm74 8898 9 - - HYPH cord-015021-pol2qm74 8898 10 gene gene NN cord-015021-pol2qm74 8898 11 activation activation NN cord-015021-pol2qm74 8898 12 is be VBZ cord-015021-pol2qm74 8898 13 also also RB cord-015021-pol2qm74 8898 14 involved involve VBN cord-015021-pol2qm74 8898 15 in in IN cord-015021-pol2qm74 8898 16 injury injury NN cord-015021-pol2qm74 8898 17 and and CC cord-015021-pol2qm74 8898 18 wound wound VB cord-015021-pol2qm74 8898 19 healing healing NN cord-015021-pol2qm74 8898 20 , , , cord-015021-pol2qm74 8898 21 which which WDT cord-015021-pol2qm74 8898 22 likewise likewise RB cord-015021-pol2qm74 8898 23 resemble resemble VBP cord-015021-pol2qm74 8898 24 a a DT cord-015021-pol2qm74 8898 25 stress stress NN cord-015021-pol2qm74 8898 26 situation situation NN cord-015021-pol2qm74 8898 27 for for IN cord-015021-pol2qm74 8898 28 cells cell NNS cord-015021-pol2qm74 8898 29 . . . cord-015021-pol2qm74 8899 1 Therefore therefore RB cord-015021-pol2qm74 8899 2 we -PRON- PRP cord-015021-pol2qm74 8899 3 collected collect VBD cord-015021-pol2qm74 8899 4 tissue tissue NN cord-015021-pol2qm74 8899 5 samples sample NNS cord-015021-pol2qm74 8899 6 during during IN cord-015021-pol2qm74 8899 7 operation operation NN cord-015021-pol2qm74 8899 8 and and CC cord-015021-pol2qm74 8899 9 single single JJ cord-015021-pol2qm74 8899 10 biopsies biopsy NNS cord-015021-pol2qm74 8899 11 from from IN cord-015021-pol2qm74 8899 12 chronic chronic JJ cord-015021-pol2qm74 8899 13 wounds wound NNS cord-015021-pol2qm74 8899 14 ( ( -LRB- cord-015021-pol2qm74 8899 15 Decubitus Decubitus NNP cord-015021-pol2qm74 8899 16 for for IN cord-015021-pol2qm74 8899 17 example example NN cord-015021-pol2qm74 8899 18 ) ) -RRB- cord-015021-pol2qm74 8899 19 and and CC cord-015021-pol2qm74 8899 20 granulation granulation NN cord-015021-pol2qm74 8899 21 tissue tissue NN cord-015021-pol2qm74 8899 22 . . . cord-015021-pol2qm74 8900 1 After after IN cord-015021-pol2qm74 8900 2 RNA rna NN cord-015021-pol2qm74 8900 3 preparation preparation NN cord-015021-pol2qm74 8900 4 from from IN cord-015021-pol2qm74 8900 5 these these DT cord-015021-pol2qm74 8900 6 samples sample NNS cord-015021-pol2qm74 8900 7 we -PRON- PRP cord-015021-pol2qm74 8900 8 used use VBD cord-015021-pol2qm74 8900 9 RNA RNA NNP cord-015021-pol2qm74 8900 10 - - HYPH cord-015021-pol2qm74 8900 11 PCR PCR NNP cord-015021-pol2qm74 8900 12 and and CC cord-015021-pol2qm74 8900 13 Nothern nothern JJ cord-015021-pol2qm74 8900 14 analysis analysis NN cord-015021-pol2qm74 8900 15 to to TO cord-015021-pol2qm74 8900 16 study study VB cord-015021-pol2qm74 8900 17 the the DT cord-015021-pol2qm74 8900 18 expression expression NN cord-015021-pol2qm74 8900 19 of of IN cord-015021-pol2qm74 8900 20 Objectives Objectives NNPS cord-015021-pol2qm74 8900 21 of of IN cord-015021-pol2qm74 8900 22 the the DT cord-015021-pol2qm74 8900 23 study study NN cord-015021-pol2qm74 8900 24 Chronic Chronic NNP cord-015021-pol2qm74 8900 25 , , , cord-015021-pol2qm74 8900 26 non non JJ cord-015021-pol2qm74 8900 27 - - JJ cord-015021-pol2qm74 8900 28 healing healing JJ cord-015021-pol2qm74 8900 29 cutaneous cutaneous JJ cord-015021-pol2qm74 8900 30 tflcers tflcer NNS cord-015021-pol2qm74 8900 31 are be VBP cord-015021-pol2qm74 8900 32 a a DT cord-015021-pol2qm74 8900 33 challenging challenge VBG cord-015021-pol2qm74 8900 34 clinical clinical JJ cord-015021-pol2qm74 8900 35 and and CC cord-015021-pol2qm74 8900 36 socioeconomic socioeconomic JJ cord-015021-pol2qm74 8900 37 problem problem NN cord-015021-pol2qm74 8900 38 . . . cord-015021-pol2qm74 8901 1 Several several JJ cord-015021-pol2qm74 8901 2 animal animal NN cord-015021-pol2qm74 8901 3 studies study NNS cord-015021-pol2qm74 8901 4 have have VBP cord-015021-pol2qm74 8901 5 shown show VBN cord-015021-pol2qm74 8901 6 that that IN cord-015021-pol2qm74 8901 7 cytukines cytukine NNS cord-015021-pol2qm74 8901 8 ( ( -LRB- cord-015021-pol2qm74 8901 9 e.g. e.g. RB cord-015021-pol2qm74 8901 10 EGF EGF NNP cord-015021-pol2qm74 8901 11 , , , cord-015021-pol2qm74 8901 12 PDGF PDGF NNP cord-015021-pol2qm74 8901 13 , , , cord-015021-pol2qm74 8901 14 FGF FGF NNP cord-015021-pol2qm74 8901 15 , , , cord-015021-pol2qm74 8901 16 TGFB TGFB NNP cord-015021-pol2qm74 8901 17 ) ) -RRB- cord-015021-pol2qm74 8901 18 accelerate accelerate VBP cord-015021-pol2qm74 8901 19 the the DT cord-015021-pol2qm74 8901 20 healing healing NN cord-015021-pol2qm74 8901 21 process process NN cord-015021-pol2qm74 8901 22 and and CC cord-015021-pol2qm74 8901 23 tissue tissue NN cord-015021-pol2qm74 8901 24 repair repair NN cord-015021-pol2qm74 8901 25 in in IN cord-015021-pol2qm74 8901 26 general general NN cord-015021-pol2qm74 8901 27 . . . cord-015021-pol2qm74 8902 1 Results result NNS cord-015021-pol2qm74 8902 2 from from IN cord-015021-pol2qm74 8902 3 first first JJ cord-015021-pol2qm74 8902 4 clinical clinical JJ cord-015021-pol2qm74 8902 5 trials trial NNS cord-015021-pol2qm74 8902 6 indicate indicate VBP cord-015021-pol2qm74 8902 7 a a DT cord-015021-pol2qm74 8902 8 promising promising JJ cord-015021-pol2qm74 8902 9 value value NN cord-015021-pol2qm74 8902 10 of of IN cord-015021-pol2qm74 8902 11 cytokines cytokine NNS cord-015021-pol2qm74 8902 12 in in IN cord-015021-pol2qm74 8902 13 the the DT cord-015021-pol2qm74 8902 14 treatment treatment NN cord-015021-pol2qm74 8902 15 of of IN cord-015021-pol2qm74 8902 16 chronic chronic JJ cord-015021-pol2qm74 8902 17 non non JJ cord-015021-pol2qm74 8902 18 - - JJ cord-015021-pol2qm74 8902 19 healing healing JJ cord-015021-pol2qm74 8902 20 diabetic diabetic JJ cord-015021-pol2qm74 8902 21 and and CC cord-015021-pol2qm74 8902 22 venous venous JJ cord-015021-pol2qm74 8902 23 ulcers ulcer NNS cord-015021-pol2qm74 8902 24 . . . cord-015021-pol2qm74 8903 1 Recent recent JJ cord-015021-pol2qm74 8903 2 reports report NNS cord-015021-pol2qm74 8903 3 in in IN cord-015021-pol2qm74 8903 4 the the DT cord-015021-pol2qm74 8903 5 literature literature NN cord-015021-pol2qm74 8903 6 indicate indicate VBP cord-015021-pol2qm74 8903 7 that that IN cord-015021-pol2qm74 8903 8 the the DT cord-015021-pol2qm74 8903 9 biological biological JJ cord-015021-pol2qm74 8903 10 activity activity NN cord-015021-pol2qm74 8903 11 of of IN cord-015021-pol2qm74 8903 12 the the DT cord-015021-pol2qm74 8903 13 solution solution NN cord-015021-pol2qm74 8903 14 of of IN cord-015021-pol2qm74 8903 15 platlet platlet NN cord-015021-pol2qm74 8903 16 derived derive VBN cord-015021-pol2qm74 8903 17 wound wound NN cord-015021-pol2qm74 8903 18 healing healing NN cord-015021-pol2qm74 8903 19 formula formula NN cord-015021-pol2qm74 8903 20 ( ( -LRB- cord-015021-pol2qm74 8903 21 PDWt~ pdwt~ RB cord-015021-pol2qm74 8903 22 ) ) -RRB- cord-015021-pol2qm74 8903 23 released release VBN cord-015021-pol2qm74 8903 24 from from IN cord-015021-pol2qm74 8903 25 c~-granules c~-granule NNS cord-015021-pol2qm74 8903 26 ( ( -LRB- cord-015021-pol2qm74 8903 27 mainly mainly RB cord-015021-pol2qm74 8903 28 PDGF PDGF NNP cord-015021-pol2qm74 8903 29 & & CC cord-015021-pol2qm74 8903 30 TGFI~ TGFI~ NNP cord-015021-pol2qm74 8903 31 ) ) -RRB- cord-015021-pol2qm74 8903 32 is be VBZ cord-015021-pol2qm74 8903 33 greater great JJR cord-015021-pol2qm74 8903 34 than than IN cord-015021-pol2qm74 8903 35 the the DT cord-015021-pol2qm74 8903 36 activity activity NN cord-015021-pol2qm74 8903 37 of of IN cord-015021-pol2qm74 8903 38 the the DT cord-015021-pol2qm74 8903 39 recombiant recombiant JJ cord-015021-pol2qm74 8903 40 single single JJ cord-015021-pol2qm74 8903 41 factors factor NNS cord-015021-pol2qm74 8903 42 like like IN cord-015021-pol2qm74 8903 43 e.g. e.g. RB cord-015021-pol2qm74 8903 44 PDGF PDGF NNP cord-015021-pol2qm74 8903 45 - - HYPH cord-015021-pol2qm74 8903 46 BB BB NNP cord-015021-pol2qm74 8904 1 ( ( -LRB- cord-015021-pol2qm74 8904 2 Robson Robson NNP cord-015021-pol2qm74 8904 3 , , , cord-015021-pol2qm74 8904 4 Lancet Lancet NNP cord-015021-pol2qm74 8904 5 1992 1992 CD cord-015021-pol2qm74 8904 6 ) ) -RRB- cord-015021-pol2qm74 8904 7 . . . cord-015021-pol2qm74 8905 1 The the DT cord-015021-pol2qm74 8905 2 aim aim NN cord-015021-pol2qm74 8905 3 of of IN cord-015021-pol2qm74 8905 4 our -PRON- PRP$ cord-015021-pol2qm74 8905 5 study study NN cord-015021-pol2qm74 8905 6 was be VBD cord-015021-pol2qm74 8905 7 to to TO cord-015021-pol2qm74 8905 8 determine determine VB cord-015021-pol2qm74 8905 9 whether whether IN cord-015021-pol2qm74 8905 10 a a DT cord-015021-pol2qm74 8905 11 correlation correlation NN cord-015021-pol2qm74 8905 12 exits exit VBZ cord-015021-pol2qm74 8905 13 between between IN cord-015021-pol2qm74 8905 14 the the DT cord-015021-pol2qm74 8905 15 concentration concentration NN cord-015021-pol2qm74 8905 16 of of IN cord-015021-pol2qm74 8905 17 TGFI~ TGFI~ NNP cord-015021-pol2qm74 8905 18 & & CC cord-015021-pol2qm74 8905 19 PDGF PDGF NNP cord-015021-pol2qm74 8905 20 and and CC cord-015021-pol2qm74 8905 21 the the DT cord-015021-pol2qm74 8905 22 time time NN cord-015021-pol2qm74 8905 23 course course NN cord-015021-pol2qm74 8905 24 of of IN cord-015021-pol2qm74 8905 25 wound wound NN cord-015021-pol2qm74 8905 26 healing healing NN cord-015021-pol2qm74 8905 27 . . . cord-015021-pol2qm74 8906 1 Materials material NNS cord-015021-pol2qm74 8906 2 and and CC cord-015021-pol2qm74 8906 3 methods method NNS cord-015021-pol2qm74 8906 4 PDWHF PDWHF NNP cord-015021-pol2qm74 8906 5 was be VBD cord-015021-pol2qm74 8906 6 prepared prepare VBN cord-015021-pol2qm74 8906 7 from from IN cord-015021-pol2qm74 8906 8 200ml 200ml CD cord-015021-pol2qm74 8906 9 of of IN cord-015021-pol2qm74 8906 10 auto]ogous auto]ogous JJ cord-015021-pol2qm74 8906 11 patient patient JJ cord-015021-pol2qm74 8906 12 blood blood NN cord-015021-pol2qm74 8906 13 and and CC cord-015021-pol2qm74 8906 14 diluted dilute VBN cord-015021-pol2qm74 8906 15 with with IN cord-015021-pol2qm74 8906 16 a a DT cord-015021-pol2qm74 8906 17 special special JJ cord-015021-pol2qm74 8906 18 buffer buffer NN cord-015021-pol2qm74 8906 19 to to IN cord-015021-pol2qm74 8906 20 a a DT cord-015021-pol2qm74 8906 21 final final JJ cord-015021-pol2qm74 8906 22 concentration concentration NN cord-015021-pol2qm74 8906 23 of of IN cord-015021-pol2qm74 8906 24 30 30 CD cord-015021-pol2qm74 8906 25 ng ng NN cord-015021-pol2qm74 8906 26 / / SYM cord-015021-pol2qm74 8906 27 ml ml NN cord-015021-pol2qm74 8906 28 g g NNP cord-015021-pol2qm74 8906 29 - - HYPH cord-015021-pol2qm74 8906 30 thromboglobulin thromboglobulin NNP cord-015021-pol2qm74 8906 31 . . . cord-015021-pol2qm74 8907 1 The the DT cord-015021-pol2qm74 8907 2 concentrations concentration NNS cord-015021-pol2qm74 8907 3 of of IN cord-015021-pol2qm74 8907 4 PDGF PDGF NNP cord-015021-pol2qm74 8907 5 and and CC cord-015021-pol2qm74 8907 6 TGFg TGFg NNP cord-015021-pol2qm74 8907 7 were be VBD cord-015021-pol2qm74 8907 8 determined determine VBN cord-015021-pol2qm74 8907 9 by by IN cord-015021-pol2qm74 8907 10 ELISA ELISA NNP cord-015021-pol2qm74 8907 11 - - HYPH cord-015021-pol2qm74 8907 12 tests test NNS cord-015021-pol2qm74 8907 13 developed develop VBN cord-015021-pol2qm74 8907 14 in in IN cord-015021-pol2qm74 8907 15 our -PRON- PRP$ cord-015021-pol2qm74 8907 16 laboratory laboratory NN cord-015021-pol2qm74 8907 17 . . . cord-015021-pol2qm74 8908 1 22 22 CD cord-015021-pol2qm74 8908 2 patients patient NNS cord-015021-pol2qm74 8908 3 with with IN cord-015021-pol2qm74 8908 4 chronic chronic JJ cord-015021-pol2qm74 8908 5 non non JJ cord-015021-pol2qm74 8908 6 - - JJ cord-015021-pol2qm74 8908 7 healing healing JJ cord-015021-pol2qm74 8908 8 ulcers ulcer NNS cord-015021-pol2qm74 8908 9 have have VBP cord-015021-pol2qm74 8908 10 been be VBN cord-015021-pol2qm74 8908 11 evaluated evaluate VBN cord-015021-pol2qm74 8908 12 alter alter JJ cord-015021-pol2qm74 8908 13 treatment treatment NN cord-015021-pol2qm74 8908 14 by by IN cord-015021-pol2qm74 8908 15 topical topical JJ cord-015021-pol2qm74 8908 16 application application NN cord-015021-pol2qm74 8908 17 of of IN cord-015021-pol2qm74 8908 18 PDWHF PDWHF NNP cord-015021-pol2qm74 8908 19 . . . cord-015021-pol2qm74 8909 1 PDFG PDFG NNP cord-015021-pol2qm74 8909 2 and and CC cord-015021-pol2qm74 8909 3 TGFf~ TGFf~ NNP cord-015021-pol2qm74 8909 4 concentrations concentration NNS cord-015021-pol2qm74 8909 5 of of IN cord-015021-pol2qm74 8909 6 the the DT cord-015021-pol2qm74 8909 7 topical topical JJ cord-015021-pol2qm74 8909 8 solution solution NN cord-015021-pol2qm74 8909 9 were be VBD cord-015021-pol2qm74 8909 10 measured measure VBN cord-015021-pol2qm74 8909 11 and and CC cord-015021-pol2qm74 8909 12 two two CD cord-015021-pol2qm74 8909 13 patient patient JJ cord-015021-pol2qm74 8909 14 groups group NNS cord-015021-pol2qm74 8909 15 formed form VBN cord-015021-pol2qm74 8909 16 for for IN cord-015021-pol2qm74 8909 17 analysis analysis NN cord-015021-pol2qm74 8910 1 The the DT cord-015021-pol2qm74 8910 2 time time NN cord-015021-pol2qm74 8910 3 course course NN cord-015021-pol2qm74 8910 4 of of IN cord-015021-pol2qm74 8910 5 wound wound NN cord-015021-pol2qm74 8910 6 healing healing NN cord-015021-pol2qm74 8910 7 was be VBD cord-015021-pol2qm74 8910 8 regularly regularly RB cord-015021-pol2qm74 8910 9 and and CC cord-015021-pol2qm74 8910 10 meticulously meticulously RB cord-015021-pol2qm74 8910 11 documented document VBN cord-015021-pol2qm74 8910 12 and and CC cord-015021-pol2qm74 8910 13 evaluated evaluate VBN cord-015021-pol2qm74 8910 14 by by IN cord-015021-pol2qm74 8910 15 photography photography NN cord-015021-pol2qm74 8910 16 and and CC cord-015021-pol2qm74 8910 17 casting casting NN cord-015021-pol2qm74 8910 18 . . . cord-015021-pol2qm74 8911 1 The the DT cord-015021-pol2qm74 8911 2 time time NN cord-015021-pol2qm74 8911 3 from from IN cord-015021-pol2qm74 8911 4 initiation initiation NN cord-015021-pol2qm74 8911 5 of of IN cord-015021-pol2qm74 8911 6 treatment treatment NN cord-015021-pol2qm74 8911 7 instil instil VBP cord-015021-pol2qm74 8911 8 o o NN cord-015021-pol2qm74 8911 9 wound wound NN cord-015021-pol2qm74 8911 10 volume volume NN cord-015021-pol2qm74 8911 11 reduction reduction NN cord-015021-pol2qm74 8911 12 to to IN cord-015021-pol2qm74 8911 13 50 50 CD cord-015021-pol2qm74 8911 14 go go NN cord-015021-pol2qm74 8911 15 of of IN cord-015021-pol2qm74 8911 16 the the DT cord-015021-pol2qm74 8911 17 origional origional JJ cord-015021-pol2qm74 8911 18 size size NN cord-015021-pol2qm74 8911 19 ( ( -LRB- cord-015021-pol2qm74 8911 20 T50 T50 NNP cord-015021-pol2qm74 8911 21 % % NN cord-015021-pol2qm74 8911 22 ) ) -RRB- cord-015021-pol2qm74 8911 23 was be VBD cord-015021-pol2qm74 8911 24 noted• noted• NNP cord-015021-pol2qm74 8911 25 Results result NNS cord-015021-pol2qm74 8911 26 : : : cord-015021-pol2qm74 8912 1 Healing healing NN cord-015021-pol2qm74 8912 2 of of IN cord-015021-pol2qm74 8912 3 extensive extensive JJ cord-015021-pol2qm74 8912 4 burn burn NN cord-015021-pol2qm74 8912 5 wounds wound NNS cord-015021-pol2qm74 8912 6 can can MD cord-015021-pol2qm74 8912 7 be be VB cord-015021-pol2qm74 8912 8 accelerated accelerate VBN cord-015021-pol2qm74 8912 9 by by IN cord-015021-pol2qm74 8912 10 grafting graft VBG cord-015021-pol2qm74 8912 11 cultured cultured JJ cord-015021-pol2qm74 8912 12 autologous autologous JJ cord-015021-pol2qm74 8912 13 or or CC cord-015021-pol2qm74 8912 14 allogeneic allogeneic NN cord-015021-pol2qm74 8912 15 keratinocytes keratinocyte NNS cord-015021-pol2qm74 8912 16 . . . cord-015021-pol2qm74 8913 1 The the DT cord-015021-pol2qm74 8913 2 stimulation stimulation NN cord-015021-pol2qm74 8913 3 of of IN cord-015021-pol2qm74 8913 4 granulation granulation NN cord-015021-pol2qm74 8913 5 tissue tissue NN cord-015021-pol2qm74 8913 6 formation formation NN cord-015021-pol2qm74 8913 7 and and CC cord-015021-pol2qm74 8913 8 reepithelialization reepithelialization NN cord-015021-pol2qm74 8913 9 is be VBZ cord-015021-pol2qm74 8913 10 presumably presumably RB cord-015021-pol2qm74 8913 11 based base VBN cord-015021-pol2qm74 8913 12 on on IN cord-015021-pol2qm74 8913 13 growth growth NN cord-015021-pol2qm74 8913 14 factors factor NNS cord-015021-pol2qm74 8913 15 and and CC cord-015021-pol2qm74 8913 16 cytokines cytokine NNS cord-015021-pol2qm74 8913 17 released release VBN cord-015021-pol2qm74 8913 18 by by IN cord-015021-pol2qm74 8913 19 keratinocytes keratinocyte NNS cord-015021-pol2qm74 8913 20 . . . cord-015021-pol2qm74 8914 1 We -PRON- PRP cord-015021-pol2qm74 8914 2 wanted want VBD cord-015021-pol2qm74 8914 3 to to TO cord-015021-pol2qm74 8914 4 prove prove VB cord-015021-pol2qm74 8914 5 this this DT cord-015021-pol2qm74 8914 6 hypothesis hypothesis NN cord-015021-pol2qm74 8914 7 by by IN cord-015021-pol2qm74 8914 8 investigating investigate VBG cord-015021-pol2qm74 8914 9 the the DT cord-015021-pol2qm74 8914 10 bFGF bfgf JJ cord-015021-pol2qm74 8914 11 expression expression NN cord-015021-pol2qm74 8914 12 during during IN cord-015021-pol2qm74 8914 13 wound wound NN cord-015021-pol2qm74 8914 14 development development NN cord-015021-pol2qm74 8914 15 , , , cord-015021-pol2qm74 8914 16 bFGF bfgf NN cord-015021-pol2qm74 8914 17 is be VBZ cord-015021-pol2qm74 8914 18 mainly mainly RB cord-015021-pol2qm74 8914 19 described describe VBN cord-015021-pol2qm74 8914 20 as as IN cord-015021-pol2qm74 8914 21 an an DT cord-015021-pol2qm74 8914 22 angiogenic angiogenic JJ cord-015021-pol2qm74 8914 23 protein protein NN cord-015021-pol2qm74 8914 24 with with IN cord-015021-pol2qm74 8914 25 mitogenic mitogenic JJ cord-015021-pol2qm74 8914 26 activity activity NN cord-015021-pol2qm74 8914 27 on on IN cord-015021-pol2qm74 8914 28 various various JJ cord-015021-pol2qm74 8914 29 mesodermal mesodermal JJ cord-015021-pol2qm74 8914 30 and and CC cord-015021-pol2qm74 8914 31 ectodermal ectodermal JJ cord-015021-pol2qm74 8914 32 cell cell NN cord-015021-pol2qm74 8914 33 types type NNS cord-015021-pol2qm74 8914 34 pointing point VBG cord-015021-pol2qm74 8914 35 to to IN cord-015021-pol2qm74 8914 36 its -PRON- PRP$ cord-015021-pol2qm74 8914 37 stimulating stimulating JJ cord-015021-pol2qm74 8914 38 potential potential NN cord-015021-pol2qm74 8914 39 in in IN cord-015021-pol2qm74 8914 40 wound wound NN cord-015021-pol2qm74 8914 41 heating heating NN cord-015021-pol2qm74 8914 42 . . . cord-015021-pol2qm74 8915 1 In in IN cord-015021-pol2qm74 8915 2 the the DT cord-015021-pol2qm74 8915 3 present present JJ cord-015021-pol2qm74 8915 4 study study NN cord-015021-pol2qm74 8915 5 we -PRON- PRP cord-015021-pol2qm74 8915 6 compared compare VBD cord-015021-pol2qm74 8915 7 the the DT cord-015021-pol2qm74 8915 8 pattern pattern NN cord-015021-pol2qm74 8915 9 of of IN cord-015021-pol2qm74 8915 10 human human NN cord-015021-pol2qm74 8915 11 bFGF bfgf NN cord-015021-pol2qm74 8915 12 m m NNP cord-015021-pol2qm74 8915 13 - - HYPH cord-015021-pol2qm74 8915 14 RNA RNA NNP cord-015021-pol2qm74 8915 15 expression expression NN cord-015021-pol2qm74 8915 16 and and CC cord-015021-pol2qm74 8915 17 the the DT cord-015021-pol2qm74 8915 18 localization localization NN cord-015021-pol2qm74 8915 19 of of IN cord-015021-pol2qm74 8915 20 bFGF bfgf NN cord-015021-pol2qm74 8915 21 protein protein NN cord-015021-pol2qm74 8915 22 during during IN cord-015021-pol2qm74 8915 23 the the DT cord-015021-pol2qm74 8915 24 first first JJ cord-015021-pol2qm74 8915 25 days day NNS cord-015021-pol2qm74 8915 26 of of IN cord-015021-pol2qm74 8915 27 wound wound NN cord-015021-pol2qm74 8915 28 healing healing NN cord-015021-pol2qm74 8915 29 . . . cord-015021-pol2qm74 8916 1 Biopsies biopsy NNS cord-015021-pol2qm74 8916 2 were be VBD cord-015021-pol2qm74 8916 3 taken take VBN cord-015021-pol2qm74 8916 4 from from IN cord-015021-pol2qm74 8916 5 5 5 CD cord-015021-pol2qm74 8916 6 juvenile juvenile JJ cord-015021-pol2qm74 8916 7 human human JJ cord-015021-pol2qm74 8916 8 bum bum NN cord-015021-pol2qm74 8916 9 patients patient NNS cord-015021-pol2qm74 8916 10 , , , cord-015021-pol2qm74 8916 11 immediately immediately RB cord-015021-pol2qm74 8916 12 after after IN cord-015021-pol2qm74 8916 13 wound wind VBD cord-015021-pol2qm74 8916 14 debridemerit debridemerit NNP cord-015021-pol2qm74 8916 15 mad mad JJ cord-015021-pol2qm74 8916 16 on on IN cord-015021-pol2qm74 8916 17 day day NN cord-015021-pol2qm74 8916 18 8 8 CD cord-015021-pol2qm74 8916 19 after after IN cord-015021-pol2qm74 8916 20 transplantation transplantation NN cord-015021-pol2qm74 8916 21 of of IN cord-015021-pol2qm74 8916 22 cultured cultured JJ cord-015021-pol2qm74 8916 23 allografts allograft NNS cord-015021-pol2qm74 8916 24 . . . cord-015021-pol2qm74 8917 1 Biopsies biopsy NNS cord-015021-pol2qm74 8917 2 were be VBD cord-015021-pol2qm74 8917 3 snap snap VB cord-015021-pol2qm74 8917 4 frozen freeze VBN cord-015021-pol2qm74 8917 5 and and CC cord-015021-pol2qm74 8917 6 cryosected cryosected JJ cord-015021-pol2qm74 8917 7 . . . cord-015021-pol2qm74 8918 1 The the DT cord-015021-pol2qm74 8918 2 pattern pattern NN cord-015021-pol2qm74 8918 3 of of IN cord-015021-pol2qm74 8918 4 bFGF bfgf JJ cord-015021-pol2qm74 8918 5 expression expression NN cord-015021-pol2qm74 8918 6 was be VBD cord-015021-pol2qm74 8918 7 assessed assess VBN cord-015021-pol2qm74 8918 8 by by IN cord-015021-pol2qm74 8918 9 in in IN cord-015021-pol2qm74 8918 10 situ situ JJ cord-015021-pol2qm74 8918 11 hybridization hybridization NN cord-015021-pol2qm74 8918 12 of of IN cord-015021-pol2qm74 8918 13 the the DT cord-015021-pol2qm74 8918 14 bFGF bfgf NN cord-015021-pol2qm74 8918 15 m m NNP cord-015021-pol2qm74 8918 16 - - HYPH cord-015021-pol2qm74 8918 17 RNA RNA NNP cord-015021-pol2qm74 8918 18 with with IN cord-015021-pol2qm74 8918 19 a a DT cord-015021-pol2qm74 8918 20 digoxigenin digoxigenin NN cord-015021-pol2qm74 8918 21 - - HYPH cord-015021-pol2qm74 8918 22 labelled label VBN cord-015021-pol2qm74 8918 23 antisense antisense NN cord-015021-pol2qm74 8918 24 - - HYPH cord-015021-pol2qm74 8918 25 RNA RNA NNP cord-015021-pol2qm74 8918 26 and and CC cord-015021-pol2qm74 8918 27 the the DT cord-015021-pol2qm74 8918 28 parallel parallel JJ cord-015021-pol2qm74 8918 29 detection detection NN cord-015021-pol2qm74 8918 30 of of IN cord-015021-pol2qm74 8918 31 the the DT cord-015021-pol2qm74 8918 32 mature mature JJ cord-015021-pol2qm74 8918 33 protein protein NN cord-015021-pol2qm74 8918 34 with with IN cord-015021-pol2qm74 8918 35 an an DT cord-015021-pol2qm74 8918 36 anfi anfi NNP cord-015021-pol2qm74 8918 37 - - HYPH cord-015021-pol2qm74 8918 38 bFGF bfgf NN cord-015021-pol2qm74 8918 39 monoclonal monoclonal JJ cord-015021-pol2qm74 8918 40 antibody antibody NN cord-015021-pol2qm74 8918 41 . . . cord-015021-pol2qm74 8919 1 Our -PRON- PRP$ cord-015021-pol2qm74 8919 2 study study NN cord-015021-pol2qm74 8919 3 revealed reveal VBD cord-015021-pol2qm74 8919 4 typical typical JJ cord-015021-pol2qm74 8919 5 patterns pattern NNS cord-015021-pol2qm74 8919 6 of of IN cord-015021-pol2qm74 8919 7 bFGF bfgf JJ cord-015021-pol2qm74 8919 8 - - HYPH cord-015021-pol2qm74 8919 9 m m NNP cord-015021-pol2qm74 8919 10 - - HYPH cord-015021-pol2qm74 8919 11 RNA rna NN cord-015021-pol2qm74 8919 12 - - HYPH cord-015021-pol2qm74 8919 13 expression expression NN cord-015021-pol2qm74 8919 14 and and CC cord-015021-pol2qm74 8919 15 intense intense JJ cord-015021-pol2qm74 8919 16 bFGFprotein bFGFprotein NNP cord-015021-pol2qm74 8919 17 deposition deposition NN cord-015021-pol2qm74 8919 18 during during IN cord-015021-pol2qm74 8919 19 granulation granulation NN cord-015021-pol2qm74 8919 20 tissue tissue NN cord-015021-pol2qm74 8919 21 formation formation NN cord-015021-pol2qm74 8919 22 and and CC cord-015021-pol2qm74 8919 23 reepithelialJzation reepithelialjzation NN cord-015021-pol2qm74 8919 24 of of IN cord-015021-pol2qm74 8919 25 healing heal VBG cord-015021-pol2qm74 8919 26 bum bum NN cord-015021-pol2qm74 8919 27 wounds wound NNS cord-015021-pol2qm74 8919 28 . . . cord-015021-pol2qm74 8919 29 ' ' '' cord-015021-pol2qm74 8920 1 it -PRON- PRP cord-015021-pol2qm74 8920 2 , , , cord-015021-pol2qm74 8920 3 is be VBZ cord-015021-pol2qm74 8920 4 known know VBN cord-015021-pol2qm74 8920 5 that that IN cord-015021-pol2qm74 8920 6 major major JJ cord-015021-pol2qm74 8920 7 thermal thermal JJ cord-015021-pol2qm74 8920 8 injuries injury NNS cord-015021-pol2qm74 8920 9 cause cause VBP cord-015021-pol2qm74 8920 10 early early JJ cord-015021-pol2qm74 8920 11 impairment impairment NN cord-015021-pol2qm74 8920 12 of of IN cord-015021-pol2qm74 8920 13 wound wound JJ cord-015021-pol2qm74 8920 14 healing healing NN cord-015021-pol2qm74 8920 15 followed follow VBN cord-015021-pol2qm74 8920 16 by by IN cord-015021-pol2qm74 8920 17 decreased decrease VBN cord-015021-pol2qm74 8920 18 influx influx NN cord-015021-pol2qm74 8920 19 of of IN cord-015021-pol2qm74 8920 20 granuiocytes granuiocyte NNS cord-015021-pol2qm74 8920 21 St. St. NNP cord-015021-pol2qm74 8920 22 the the DT cord-015021-pol2qm74 8920 23 site site NN cord-015021-pol2qm74 8920 24 of of IN cord-015021-pol2qm74 8920 25 injury injury NN cord-015021-pol2qm74 8920 26 . . . cord-015021-pol2qm74 8921 1 The the DT cord-015021-pol2qm74 8921 2 role role NN cord-015021-pol2qm74 8921 3 of of IN cord-015021-pol2qm74 8921 4 granuiocytes granuiocyte NNS cord-015021-pol2qm74 8921 5 in in IN cord-015021-pol2qm74 8921 6 the the DT cord-015021-pol2qm74 8921 7 process process NN cord-015021-pol2qm74 8921 8 of of IN cord-015021-pol2qm74 8921 9 wound wound JJ cord-015021-pol2qm74 8921 10 healing healing NN cord-015021-pol2qm74 8921 11 is be VBZ cord-015021-pol2qm74 8921 12 not not RB cord-015021-pol2qm74 8921 13 ~"~ ~"~ NNP cord-015021-pol2qm74 8921 14 " " '' cord-015021-pol2qm74 8921 15 " " `` cord-015021-pol2qm74 8921 16 elucidated elucidate VBN cord-015021-pol2qm74 8921 17 , , , cord-015021-pol2qm74 8921 18 it -PRON- PRP cord-015021-pol2qm74 8921 19 is be VBZ cord-015021-pol2qm74 8921 20 now now RB cord-015021-pol2qm74 8921 21 assumed assume VBN cord-015021-pol2qm74 8921 22 that that IN cord-015021-pol2qm74 8921 23 they -PRON- PRP cord-015021-pol2qm74 8921 24 are be VBP cord-015021-pol2qm74 8921 25 not not RB cord-015021-pol2qm74 8921 26 merely merely RB cord-015021-pol2qm74 8921 27 phagocytic phagocytic JJ cord-015021-pol2qm74 8921 28 cells cell NNS cord-015021-pol2qm74 8921 29 but but CC cord-015021-pol2qm74 8921 30 active active JJ cord-015021-pol2qm74 8921 31 participants participant NNS cord-015021-pol2qm74 8921 32 in in IN cord-015021-pol2qm74 8921 33 ~n~*'1~. ~n~*'1~. NNP cord-015021-pol2qm74 8921 34 , , , cord-015021-pol2qm74 8921 35 . . . cord-015021-pol2qm74 8922 1 , , , cord-015021-pol2qm74 8922 2 a+~o~ a+~o~ NNP cord-015021-pol2qm74 8922 3 : : : cord-015021-pol2qm74 8922 4 processes process NNS cord-015021-pol2qm74 8922 5 secreting secrete VBG cord-015021-pol2qm74 8922 6 _ _ NN cord-015021-pol2qm74 8922 7 a a DT cord-015021-pol2qm74 8922 8 number number NN cord-015021-pol2qm74 8922 9 of of IN cord-015021-pol2qm74 8922 10 various various JJ cord-015021-pol2qm74 8922 11 cvt-;kines cvt-;kine NNS cord-015021-pol2qm74 8922 12 , , , cord-015021-pol2qm74 8922 13 in in IN cord-015021-pol2qm74 8922 14 order order NN cord-015021-pol2qm74 8922 15 to to TO cord-015021-pol2qm74 8922 16 investigate investigate VB cord-015021-pol2qm74 8922 17 the the DT cord-015021-pol2qm74 8922 18 effect effect NN cord-015021-pol2qm74 8922 19 of of IN cord-015021-pol2qm74 8922 20 There there EX cord-015021-pol2qm74 8922 21 is be VBZ cord-015021-pol2qm74 8922 22 accumulating accumulate VBG cord-015021-pol2qm74 8922 23 evidence evidence NN cord-015021-pol2qm74 8922 24 that that IN cord-015021-pol2qm74 8922 25 neuropeptides neuropeptide NNS cord-015021-pol2qm74 8922 26 could could MD cord-015021-pol2qm74 8922 27 be be VB cord-015021-pol2qm74 8922 28 involved involve VBN cord-015021-pol2qm74 8922 29 in in IN cord-015021-pol2qm74 8922 30 the the DT cord-015021-pol2qm74 8922 31 pathogenesis pathogenesis NN cord-015021-pol2qm74 8922 32 of of IN cord-015021-pol2qm74 8922 33 several several JJ cord-015021-pol2qm74 8922 34 inflammatory inflammatory JJ cord-015021-pol2qm74 8922 35 reactions reaction NNS cord-015021-pol2qm74 8922 36 . . . cord-015021-pol2qm74 8923 1 Vasocactive Vasocactive NNP cord-015021-pol2qm74 8923 2 Intestinal intestinal JJ cord-015021-pol2qm74 8923 3 Polypeptide Polypeptide NNP cord-015021-pol2qm74 8923 4 ( ( -LRB- cord-015021-pol2qm74 8923 5 VIP VIP NNP cord-015021-pol2qm74 8923 6 ) ) -RRB- cord-015021-pol2qm74 8923 7 and and CC cord-015021-pol2qm74 8923 8 Substance Substance NNP cord-015021-pol2qm74 8923 9 P p NN cord-015021-pol2qm74 8923 10 ( ( -LRB- cord-015021-pol2qm74 8923 11 SP SP NNP cord-015021-pol2qm74 8923 12 ) ) -RRB- cord-015021-pol2qm74 8923 13 have have VBP cord-015021-pol2qm74 8923 14 been be VBN cord-015021-pol2qm74 8923 15 detected detect VBN cord-015021-pol2qm74 8923 16 by by IN cord-015021-pol2qm74 8923 17 immunohistochemistry immunohistochemistry NN cord-015021-pol2qm74 8923 18 in in IN cord-015021-pol2qm74 8923 19 normal normal JJ cord-015021-pol2qm74 8923 20 as as RB cord-015021-pol2qm74 8923 21 well well RB cord-015021-pol2qm74 8923 22 as as IN cord-015021-pol2qm74 8923 23 inflammed inflammed JJ cord-015021-pol2qm74 8923 24 skin skin NN cord-015021-pol2qm74 8923 25 mostly mostly RB cord-015021-pol2qm74 8923 26 in in IN cord-015021-pol2qm74 8923 27 perivascular perivascular NNP cord-015021-pol2qm74 8923 28 and and CC cord-015021-pol2qm74 8923 29 periglandular periglandular JJ cord-015021-pol2qm74 8923 30 location location NN cord-015021-pol2qm74 8923 31 . . . cord-015021-pol2qm74 8924 1 Both both DT cord-015021-pol2qm74 8924 2 VIP VIP NNP cord-015021-pol2qm74 8924 3 and and CC cord-015021-pol2qm74 8924 4 SP SP NNP cord-015021-pol2qm74 8924 5 are be VBP cord-015021-pol2qm74 8924 6 involved involve VBN cord-015021-pol2qm74 8924 7 in in IN cord-015021-pol2qm74 8924 8 vasodilatation vasodilatation NN cord-015021-pol2qm74 8924 9 , , , cord-015021-pol2qm74 8924 10 mast mast JJ cord-015021-pol2qm74 8924 11 cell cell NN cord-015021-pol2qm74 8924 12 degranulation degranulation NN cord-015021-pol2qm74 8924 13 and and CC cord-015021-pol2qm74 8924 14 irnmunomodulation irnmunomodulation NN cord-015021-pol2qm74 8924 15 . . . cord-015021-pol2qm74 8925 1 We -PRON- PRP cord-015021-pol2qm74 8925 2 determined determine VBD cord-015021-pol2qm74 8925 3 the the DT cord-015021-pol2qm74 8925 4 influence influence NN cord-015021-pol2qm74 8925 5 of of IN cord-015021-pol2qm74 8925 6 SP SP NNP cord-015021-pol2qm74 8925 7 and and CC cord-015021-pol2qm74 8925 8 VIP vip NN cord-015021-pol2qm74 8925 9 on on IN cord-015021-pol2qm74 8925 10 the the DT cord-015021-pol2qm74 8925 11 proliferation proliferation NN cord-015021-pol2qm74 8925 12 of of IN cord-015021-pol2qm74 8925 13 lymphocytes lymphocyte NNS cord-015021-pol2qm74 8925 14 in in IN cord-015021-pol2qm74 8925 15 patients patient NNS cord-015021-pol2qm74 8925 16 with with IN cord-015021-pol2qm74 8925 17 psoriasis psoriasis NN cord-015021-pol2qm74 8925 18 and and CC cord-015021-pol2qm74 8925 19 healthy healthy JJ cord-015021-pol2qm74 8925 20 individuals individual NNS cord-015021-pol2qm74 8925 21 . . . cord-015021-pol2qm74 8926 1 Peripheral peripheral JJ cord-015021-pol2qm74 8926 2 blood blood NN cord-015021-pol2qm74 8926 3 T t NN cord-015021-pol2qm74 8926 4 - - HYPH cord-015021-pol2qm74 8926 5 lymphocytes lymphocyte NNS cord-015021-pol2qm74 8926 6 of of IN cord-015021-pol2qm74 8926 7 6 6 CD cord-015021-pol2qm74 8926 8 psoriatics psoriatic NNS cord-015021-pol2qm74 8926 9 and and CC cord-015021-pol2qm74 8926 10 6 6 CD cord-015021-pol2qm74 8926 11 healthy healthy JJ cord-015021-pol2qm74 8926 12 controls control NNS cord-015021-pol2qm74 8926 13 were be VBD cord-015021-pol2qm74 8926 14 isolated isolate VBN cord-015021-pol2qm74 8926 15 by by IN cord-015021-pol2qm74 8926 16 density density NN cord-015021-pol2qm74 8926 17 gradient gradient NN cord-015021-pol2qm74 8926 18 centrifugation centrifugation NN cord-015021-pol2qm74 8926 19 and and CC cord-015021-pol2qm74 8926 20 passage passage NN cord-015021-pol2qm74 8926 21 over over IN cord-015021-pol2qm74 8926 22 nylon nylon NN cord-015021-pol2qm74 8926 23 wool wool NN cord-015021-pol2qm74 8926 24 . . . cord-015021-pol2qm74 8927 1 Cell cell NN cord-015021-pol2qm74 8927 2 enrichment enrichment NN cord-015021-pol2qm74 8927 3 was be VBD cord-015021-pol2qm74 8927 4 controlled control VBN cord-015021-pol2qm74 8927 5 by by IN cord-015021-pol2qm74 8927 6 FACS FACS NNP cord-015021-pol2qm74 8927 7 analysis analysis NN cord-015021-pol2qm74 8927 8 , , , cord-015021-pol2qm74 8927 9 lx105 lx105 NNP cord-015021-pol2qm74 8927 10 T T NNP cord-015021-pol2qm74 8927 11 - - HYPH cord-015021-pol2qm74 8927 12 lymphocytes lymphocyte NNS cord-015021-pol2qm74 8927 13 were be VBD cord-015021-pol2qm74 8927 14 then then RB cord-015021-pol2qm74 8927 15 incubated incubate VBN cord-015021-pol2qm74 8927 16 alone alone RB cord-015021-pol2qm74 8927 17 or or CC cord-015021-pol2qm74 8927 18 in in IN cord-015021-pol2qm74 8927 19 coculture coculture NN cord-015021-pol2qm74 8927 20 with with IN cord-015021-pol2qm74 8927 21 2x104 2x104 CD cord-015021-pol2qm74 8927 22 irradiated irradiate VBN cord-015021-pol2qm74 8927 23 autologous autologous JJ cord-015021-pol2qm74 8927 24 lymphocytes lymphocyte NNS cord-015021-pol2qm74 8927 25 in in IN cord-015021-pol2qm74 8927 26 culture culture NN cord-015021-pol2qm74 8927 27 medium medium NN cord-015021-pol2qm74 8927 28 containing contain VBG cord-015021-pol2qm74 8927 29 10 10 CD cord-015021-pol2qm74 8927 30 -7 -7 NNP cord-015021-pol2qm74 8927 31 mol mol NN cord-015021-pol2qm74 8927 32 / / SYM cord-015021-pol2qm74 8927 33 I I NNP cord-015021-pol2qm74 8927 34 SP SP NNP cord-015021-pol2qm74 8927 35 or or CC cord-015021-pol2qm74 8927 36 VIP VIP NNP cord-015021-pol2qm74 8927 37 . . . cord-015021-pol2qm74 8928 1 Cell cell NN cord-015021-pol2qm74 8928 2 proliferation proliferation NN cord-015021-pol2qm74 8928 3 was be VBD cord-015021-pol2qm74 8928 4 measured measure VBN cord-015021-pol2qm74 8928 5 semiquanfitatively semiquanfitatively RB cord-015021-pol2qm74 8928 6 by by IN cord-015021-pol2qm74 8928 7 TdR tdr NN cord-015021-pol2qm74 8928 8 uptake uptake NN cord-015021-pol2qm74 8928 9 in in IN cord-015021-pol2qm74 8928 10 a a DT cord-015021-pol2qm74 8928 11 betacounter betacounter NN cord-015021-pol2qm74 8928 12 . . . cord-015021-pol2qm74 8929 1 Significance significance NN cord-015021-pol2qm74 8929 2 was be VBD cord-015021-pol2qm74 8929 3 tested test VBN cord-015021-pol2qm74 8929 4 by by IN cord-015021-pol2qm74 8929 5 the the DT cord-015021-pol2qm74 8929 6 Wilcoxon Wilcoxon NNP cord-015021-pol2qm74 8929 7 signed sign VBN cord-015021-pol2qm74 8929 8 - - HYPH cord-015021-pol2qm74 8929 9 rank rank NN cord-015021-pol2qm74 8929 10 test test NN cord-015021-pol2qm74 8929 11 . . . cord-015021-pol2qm74 8930 1 Our -PRON- PRP$ cord-015021-pol2qm74 8930 2 results result NNS cord-015021-pol2qm74 8930 3 show show VBP cord-015021-pol2qm74 8930 4 that that IN cord-015021-pol2qm74 8930 5 SP SP NNP cord-015021-pol2qm74 8930 6 and and CC cord-015021-pol2qm74 8930 7 VIP VIP NNP cord-015021-pol2qm74 8930 8 exert exert VBP cord-015021-pol2qm74 8930 9 only only RB cord-015021-pol2qm74 8930 10 an an DT cord-015021-pol2qm74 8930 11 effect effect NN cord-015021-pol2qm74 8930 12 on on IN cord-015021-pol2qm74 8930 13 unstirnulated unstirnulated JJ cord-015021-pol2qm74 8930 14 T T NNP cord-015021-pol2qm74 8930 15 - - HYPH cord-015021-pol2qm74 8930 16 cells cell NNS cord-015021-pol2qm74 8930 17 . . . cord-015021-pol2qm74 8931 1 In in IN cord-015021-pol2qm74 8931 2 healthy healthy JJ cord-015021-pol2qm74 8931 3 individuals individual NNS cord-015021-pol2qm74 8931 4 but but CC cord-015021-pol2qm74 8931 5 not not RB cord-015021-pol2qm74 8931 6 in in IN cord-015021-pol2qm74 8931 7 patients patient NNS cord-015021-pol2qm74 8931 8 with with IN cord-015021-pol2qm74 8931 9 psoriasis psoriasis NN cord-015021-pol2qm74 8931 10 SP SP NNP cord-015021-pol2qm74 8931 11 increases increase VBZ cord-015021-pol2qm74 8931 12 significantly significantly RB cord-015021-pol2qm74 8931 13 proliferation proliferation NN cord-015021-pol2qm74 8931 14 of of IN cord-015021-pol2qm74 8931 15 T t NN cord-015021-pol2qm74 8931 16 - - HYPH cord-015021-pol2qm74 8931 17 cells cell NNS cord-015021-pol2qm74 8931 18 . . . cord-015021-pol2qm74 8932 1 VIP VIP NNP cord-015021-pol2qm74 8932 2 , , , cord-015021-pol2qm74 8932 3 however however RB cord-015021-pol2qm74 8932 4 stimulates stimulate VBZ cord-015021-pol2qm74 8932 5 significantly significantly RB cord-015021-pol2qm74 8932 6 the the DT cord-015021-pol2qm74 8932 7 blastogenesis blastogenesis NN cord-015021-pol2qm74 8932 8 of of IN cord-015021-pol2qm74 8932 9 T T NNP cord-015021-pol2qm74 8932 10 - - HYPH cord-015021-pol2qm74 8932 11 lymphocytes lymphocyte NNS cord-015021-pol2qm74 8932 12 only only RB cord-015021-pol2qm74 8932 13 in in IN cord-015021-pol2qm74 8932 14 psoriatics psoriatic NNS cord-015021-pol2qm74 8932 15 . . . cord-015021-pol2qm74 8933 1 Our -PRON- PRP$ cord-015021-pol2qm74 8933 2 results result NNS cord-015021-pol2qm74 8933 3 confirm confirm VBP cord-015021-pol2qm74 8933 4 the the DT cord-015021-pol2qm74 8933 5 psychoneuroimmunologic psychoneuroimmunologic JJ cord-015021-pol2qm74 8933 6 component component NN cord-015021-pol2qm74 8933 7 in in IN cord-015021-pol2qm74 8933 8 inflammatory inflammatory JJ cord-015021-pol2qm74 8933 9 reactions reaction NNS cord-015021-pol2qm74 8933 10 and and CC cord-015021-pol2qm74 8933 11 VIP vip NN cord-015021-pol2qm74 8933 12 and and CC cord-015021-pol2qm74 8933 13 SP SP NNP cord-015021-pol2qm74 8933 14 could could MD cord-015021-pol2qm74 8933 15 be be VB cord-015021-pol2qm74 8933 16 partially partially RB cord-015021-pol2qm74 8933 17 implicated implicate VBN cord-015021-pol2qm74 8933 18 in in IN cord-015021-pol2qm74 8933 19 their -PRON- PRP$ cord-015021-pol2qm74 8933 20 pathogenetic pathogenetic JJ cord-015021-pol2qm74 8933 21 mechanisms mechanism NNS cord-015021-pol2qm74 8933 22 . . . cord-015021-pol2qm74 8934 1 Moreover moreover RB cord-015021-pol2qm74 8934 2 psoriatic psoriatic JJ cord-015021-pol2qm74 8934 3 lymphocytes lymphocyte NNS cord-015021-pol2qm74 8934 4 show show VBP cord-015021-pol2qm74 8934 5 an an DT cord-015021-pol2qm74 8934 6 altered altered JJ cord-015021-pol2qm74 8934 7 reaction reaction NN cord-015021-pol2qm74 8934 8 to to IN cord-015021-pol2qm74 8934 9 SP SP NNP cord-015021-pol2qm74 8934 10 and and CC cord-015021-pol2qm74 8934 11 VIP VIP NNP cord-015021-pol2qm74 8934 12 . . . cord-015021-pol2qm74 8935 1 This this DT cord-015021-pol2qm74 8935 2 might may MD cord-015021-pol2qm74 8935 3 be be VB cord-015021-pol2qm74 8935 4 due due JJ cord-015021-pol2qm74 8935 5 to to IN cord-015021-pol2qm74 8935 6 a a DT cord-015021-pol2qm74 8935 7 preexisting preexisting JJ cord-015021-pol2qm74 8935 8 ( ( -LRB- cord-015021-pol2qm74 8935 9 genetic genetic JJ cord-015021-pol2qm74 8935 10 ? ? . cord-015021-pol2qm74 8935 11 ) ) -RRB- cord-015021-pol2qm74 8935 12 or or CC cord-015021-pol2qm74 8935 13 more more RBR cord-015021-pol2qm74 8935 14 likely likely JJ cord-015021-pol2qm74 8935 15 to to IN cord-015021-pol2qm74 8935 16 an an DT cord-015021-pol2qm74 8935 17 epiphenomenal epiphenomenal JJ cord-015021-pol2qm74 8935 18 receptor receptor NN cord-015021-pol2qm74 8935 19 defect defect NN cord-015021-pol2qm74 8935 20 . . . cord-015021-pol2qm74 8936 1 The the DT cord-015021-pol2qm74 8936 2 adhesive adhesive JJ cord-015021-pol2qm74 8936 3 interactions interaction NNS cord-015021-pol2qm74 8936 4 between between IN cord-015021-pol2qm74 8936 5 endothelial endothelial JJ cord-015021-pol2qm74 8936 6 cells cell NNS cord-015021-pol2qm74 8936 7 and and CC cord-015021-pol2qm74 8936 8 circulating circulate VBG cord-015021-pol2qm74 8936 9 ~enkocytes ~enkocytes XX cord-015021-pol2qm74 8936 10 in in IN cord-015021-pol2qm74 8936 11 shock shock NN cord-015021-pol2qm74 8936 12 and and CC cord-015021-pol2qm74 8936 13 innammatory innammatory JJ cord-015021-pol2qm74 8936 14 vondltions vondltion NNS cord-015021-pol2qm74 8936 15 is be VBZ cord-015021-pol2qm74 8936 16 mediated mediate VBN cord-015021-pol2qm74 8936 17 by by IN cord-015021-pol2qm74 8936 18 several several JJ cord-015021-pol2qm74 8936 19 distinct distinct JJ cord-015021-pol2qm74 8936 20 families family NNS cord-015021-pol2qm74 8936 21 of of IN cord-015021-pol2qm74 8936 22 ce11-surface ce11-surface NN cord-015021-pol2qm74 8936 23 determinants determinant NNS cord-015021-pol2qm74 8936 24 . . . cord-015021-pol2qm74 8937 1 Of of IN cord-015021-pol2qm74 8937 2 particular particular JJ cord-015021-pol2qm74 8937 3 importance importance NN cord-015021-pol2qm74 8937 4 are be VBP cord-015021-pol2qm74 8937 5 the the DT cord-015021-pol2qm74 8937 6 leukocyte leukocyte NN cord-015021-pol2qm74 8937 7 integrins integrin NNS cord-015021-pol2qm74 8937 8 CDIB CDIB NNP cord-015021-pol2qm74 8937 9 / / SYM cord-015021-pol2qm74 8937 10 CDlla CDlla NNP cord-015021-pol2qm74 8937 11 - - HYPH cord-015021-pol2qm74 8937 12 c c NNP cord-015021-pol2qm74 8937 13 . . . cord-015021-pol2qm74 8938 1 In in IN cord-015021-pol2qm74 8938 2 this this DT cord-015021-pol2qm74 8938 3 study study NN cord-015021-pol2qm74 8938 4 monoclonal monoclonal JJ cord-015021-pol2qm74 8938 5 antibodies antibody NNS cord-015021-pol2qm74 8938 6 to to IN cord-015021-pol2qm74 8938 7 two two CD cord-015021-pol2qm74 8938 8 of of IN cord-015021-pol2qm74 8938 9 the the DT cord-015021-pol2qm74 8938 10 u u NNP cord-015021-pol2qm74 8938 11 chains chain NNS cord-015021-pol2qm74 8938 12 ( ( -LRB- cord-015021-pol2qm74 8938 13 CDlla CDlla NNP cord-015021-pol2qm74 8938 14 & & CC cord-015021-pol2qm74 8938 15 CDIIb CDIIb NNP cord-015021-pol2qm74 8938 16 ) ) -RRB- cord-015021-pol2qm74 8938 17 and and CC cord-015021-pol2qm74 8938 18 the the DT cord-015021-pol2qm74 8938 19 common common JJ cord-015021-pol2qm74 8938 20 [ [ -LRB- cord-015021-pol2qm74 8938 21 ~ ~ CD cord-015021-pol2qm74 8938 22 chain chain NN cord-015021-pol2qm74 8938 23 ( ( -LRB- cord-015021-pol2qm74 8938 24 CDIB CDIB NNP cord-015021-pol2qm74 8938 25 ) ) -RRB- cord-015021-pol2qm74 8938 26 have have VBP cord-015021-pol2qm74 8938 27 been be VBN cord-015021-pol2qm74 8938 28 used use VBN cord-015021-pol2qm74 8938 29 to to TO cord-015021-pol2qm74 8938 30 investigate investigate VB cord-015021-pol2qm74 8938 31 leukocyte leukocyte NN cord-015021-pol2qm74 8938 32 - - HYPH cord-015021-pol2qm74 8938 33 dependent dependent JJ cord-015021-pol2qm74 8938 34 and and CC cord-015021-pol2qm74 8938 35 leukocyte leukocyte NN cord-015021-pol2qm74 8938 36 - - HYPH cord-015021-pol2qm74 8938 37 independent independent JJ cord-015021-pol2qm74 8938 38 plasma plasma NN cord-015021-pol2qm74 8938 39 leakage leakage NN cord-015021-pol2qm74 8938 40 in in IN cord-015021-pol2qm74 8938 41 tee tee NN cord-015021-pol2qm74 8938 42 skin skin NN cord-015021-pol2qm74 8938 43 of of IN cord-015021-pol2qm74 8938 44 rabbite rabbite NNP cord-015021-pol2qm74 8938 45 . . . cord-015021-pol2qm74 8939 1 Plasma plasma NN cord-015021-pol2qm74 8939 2 leakage leakage NN cord-015021-pol2qm74 8939 3 was be VBD cord-015021-pol2qm74 8939 4 measured measure VBN cord-015021-pol2qm74 8939 5 as as IN cord-015021-pol2qm74 8939 6 the the DT cord-015021-pol2qm74 8939 7 local local JJ cord-015021-pol2qm74 8939 8 accumulation accumulation NN cord-015021-pol2qm74 8939 9 of of IN cord-015021-pol2qm74 8939 10 t2sI t2sI NNP cord-015021-pol2qm74 8939 11 - - : cord-015021-pol2qm74 8939 12 HSA HSA NNP cord-015021-pol2qm74 8939 13 over over IN cord-015021-pol2qm74 8939 14 a a DT cord-015021-pol2qm74 8939 15 30 30 CD cord-015021-pol2qm74 8939 16 rain rain NN cord-015021-pol2qm74 8939 17 period period NN cord-015021-pol2qm74 8939 18 , , , cord-015021-pol2qm74 8939 19 The the DT cord-015021-pol2qm74 8939 20 chemotac chemotac NNP cord-015021-pol2qm74 8939 21 ~ ~ NFP cord-015021-pol2qm74 8939 22 c c NNP cord-015021-pol2qm74 8939 23 peptide peptide NN cord-015021-pol2qm74 8939 24 IMLP IMLP NNP cord-015021-pol2qm74 8939 25 ( ( -LRB- cord-015021-pol2qm74 8939 26 0.1 0.1 CD cord-015021-pol2qm74 8939 27 . . . cord-015021-pol2qm74 8939 28 30ng 30ng LS cord-015021-pol2qm74 8939 29 ) ) -RRB- cord-015021-pol2qm74 8939 30 and and CC cord-015021-pol2qm74 8939 31 bradykinin bradykinin NN cord-015021-pol2qm74 8939 32 were be VBD cord-015021-pol2qm74 8939 33 used use VBN cord-015021-pol2qm74 8939 34 to to TO cord-015021-pol2qm74 8939 35 induce induce VB cord-015021-pol2qm74 8939 36 cell.dependent cell.dependent NN cord-015021-pol2qm74 8939 37 and and CC cord-015021-pol2qm74 8939 38 cell-5ndependent cell-5ndependent NN cord-015021-pol2qm74 8939 39 leakage leakage NN cord-015021-pol2qm74 8939 40 respectively respectively RB cord-015021-pol2qm74 8939 41 , , , cord-015021-pol2qm74 8939 42 The the DT cord-015021-pol2qm74 8939 43 antibodies antibody NNS cord-015021-pol2qm74 8939 44 used use VBN cord-015021-pol2qm74 8939 45 were be VBD cord-015021-pol2qm74 8939 46 6.5E 6.5E NNS cord-015021-pol2qm74 8940 1 ( ( -LRB- cord-015021-pol2qm74 8940 2 CDIS CDIS NNP cord-015021-pol2qm74 8940 3 ) ) -RRB- cord-015021-pol2qm74 8940 4 , , . cord-015021-pol2qm74 8941 1 NRI85 NRI85 NNP cord-015021-pol2qm74 8941 2 ( ( -LRB- cord-015021-pol2qm74 8941 3 CDlla CDlla NNP cord-015021-pol2qm74 8941 4 ) ) -RRB- cord-015021-pol2qm74 8941 5 and and CC cord-015021-pol2qm74 8941 6 antibody antibody NN cord-015021-pol2qm74 8941 7 198 198 CD cord-015021-pol2qm74 8941 8 ( ( -LRB- cord-015021-pol2qm74 8941 9 CDllb CDllb NNP cord-015021-pol2qm74 8941 10 ) ) -RRB- cord-015021-pol2qm74 8941 11 . . . cord-015021-pol2qm74 8941 12 ] ] -RRB- cord-015021-pol2qm74 8942 1 ntradermal ntradermal NNP cord-015021-pol2qm74 8942 2 in in IN cord-015021-pol2qm74 8942 3 ~ ~ CD cord-015021-pol2qm74 8942 4 ections ection NNS cord-015021-pol2qm74 8942 5 of of IN cord-015021-pol2qm74 8942 6 bradyklnin bradyklnin NNS cord-015021-pol2qm74 8942 7 and and CC cord-015021-pol2qm74 8942 8 ~dLP ~dLP NNP cord-015021-pol2qm74 8943 1 both both DT cord-015021-pol2qm74 8943 2 caused cause VBD cord-015021-pol2qm74 8943 3 a a DT cord-015021-pol2qm74 8943 4 dose dose NN cord-015021-pol2qm74 8943 5 dependent dependent JJ cord-015021-pol2qm74 8943 6 increase increase NN cord-015021-pol2qm74 8943 7 in in IN cord-015021-pol2qm74 8943 8 plasma plasma NN cord-015021-pol2qm74 8943 9 extravasatien extravasatien NN cord-015021-pol2qm74 8944 1 ( ( -LRB- cord-015021-pol2qm74 8944 2 15.~. 15.~. NNP cord-015021-pol2qm74 8944 3 ffi ffi NNP cord-015021-pol2qm74 8944 4 2.1p.l 2.1p.l CD cord-015021-pol2qm74 8944 5 to to IN cord-015021-pol2qm74 8944 6 54.4 54.4 CD cord-015021-pol2qm74 8944 7 z z NNP cord-015021-pol2qm74 8944 8 B.Bttl B.Bttl NNP cord-015021-pol2qm74 8944 9 and and CC cord-015021-pol2qm74 8944 10 16.4 16.4 CD cord-015021-pol2qm74 8944 11 , , , cord-015021-pol2qm74 8944 12 -1.8~ -1.8~ VBG cord-015021-pol2qm74 8944 13 to to IN cord-015021-pol2qm74 8944 14 59.8 59.8 CD cord-015021-pol2qm74 8944 15 z z NNP cord-015021-pol2qm74 8944 16 6.71d 6.71d CD cord-015021-pol2qm74 8944 17 respectively respectively RB cord-015021-pol2qm74 8944 18 . . . cord-015021-pol2qm74 8945 1 6.5E 6.5E NNS cord-015021-pol2qm74 8946 1 ( ( -LRB- cord-015021-pol2qm74 8946 2 0.0072 0.0072 CD cord-015021-pol2qm74 8946 3 - - HYPH cord-015021-pol2qm74 8946 4 2.4mF,/k~ 2.4mf,/k~ JJ cord-015021-pol2qm74 8946 5 iv iv CD cord-015021-pol2qm74 8946 6 ) ) -RRB- cord-015021-pol2qm74 8946 7 caused cause VBD cord-015021-pol2qm74 8946 8 a a DT cord-015021-pol2qm74 8946 9 dose dose JJ cord-015021-pol2qm74 8946 10 dependent dependent JJ cord-015021-pol2qm74 8946 11 inhibition inhibition NN cord-015021-pol2qm74 8946 12 of of IN cord-015021-pol2qm74 8946 13 IMLP IMLP NNP cord-015021-pol2qm74 8946 14 - - HYPH cord-015021-pol2qm74 8946 15 induced induce VBN cord-015021-pol2qm74 8946 16 but but CC cord-015021-pol2qm74 8946 17 not not RB cord-015021-pol2qm74 8946 18 bradyldnin.inducecl bradyldnin.inducecl JJ cord-015021-pol2qm74 8946 19 plasma plasma NN cord-015021-pol2qm74 8946 20 exudation exudation NN cord-015021-pol2qm74 8946 21 . . . cord-015021-pol2qm74 8947 1 At at IN cord-015021-pol2qm74 8947 2 0.24mk 0.24mk CD cord-015021-pol2qm74 8947 3 / / SYM cord-015021-pol2qm74 8947 4 kg kg NNS cord-015021-pol2qm74 8947 5 , , , cord-015021-pol2qm74 8947 6 the the DT cord-015021-pol2qm74 8947 7 plasma plasma NN cord-015021-pol2qm74 8947 8 leakage leakage NN cord-015021-pol2qm74 8947 9 was be VBD cord-015021-pol2qm74 8947 10 completely completely RB cord-015021-pol2qm74 8947 11 inhibited inhibit VBN cord-015021-pol2qm74 8947 12 , , , cord-015021-pol2qm74 8947 13 Antibody Antibody NNP cord-015021-pol2qm74 8947 14 NR185 nr185 CD cord-015021-pol2qm74 8947 15 produced produce VBD cord-015021-pol2qm74 8947 16 similar similar JJ cord-015021-pol2qm74 8947 17 results result NNS cord-015021-pol2qm74 8947 18 , , , cord-015021-pol2qm74 8947 19 Treatment treatment NN cord-015021-pol2qm74 8947 20 with with IN cord-015021-pol2qm74 8947 21 antibody antibody NN cord-015021-pol2qm74 8947 22 198 198 CD cord-015021-pol2qm74 8947 23 did do VBD cord-015021-pol2qm74 8947 24 not not RB cord-015021-pol2qm74 8947 25 cause cause VB cord-015021-pol2qm74 8947 26 inhibition inhibition NN cord-015021-pol2qm74 8947 27 o£ o£ NN cord-015021-pol2qm74 8947 28 plasma plasma NN cord-015021-pol2qm74 8947 29 leakage leakage NN cord-015021-pol2qm74 8947 30 due due IN cord-015021-pol2qm74 8947 31 to to IN cord-015021-pol2qm74 8947 32 either either CC cord-015021-pol2qm74 8947 33 Tnedi Tnedi NNP cord-015021-pol2qm74 8947 34 ~ ~ NFP cord-015021-pol2qm74 8947 35 tor tor XX cord-015021-pol2qm74 8947 36 . . . cord-015021-pol2qm74 8948 1 In in IN cord-015021-pol2qm74 8948 2 vitro vitro FW cord-015021-pol2qm74 8948 3 , , , cord-015021-pol2qm74 8948 4 The the DT cord-015021-pol2qm74 8948 5 irmnune irmnune NNP cord-015021-pol2qm74 8948 6 system system NN cord-015021-pol2qm74 8948 7 ex ex NN cord-015021-pol2qm74 8948 8 ~ ~ CD cord-015021-pol2qm74 8948 9 nination nination NN cord-015021-pol2qm74 8948 10 in in IN cord-015021-pol2qm74 8948 11 persons person NNS cord-015021-pol2qm74 8948 12 with with IN cord-015021-pol2qm74 8948 13 bone bone NN cord-015021-pol2qm74 8948 14 , , , cord-015021-pol2qm74 8948 15 chest chest NN cord-015021-pol2qm74 8948 16 and and CC cord-015021-pol2qm74 8948 17 abdominal abdominal JJ cord-015021-pol2qm74 8948 18 traumatic traumatic JJ cord-015021-pol2qm74 8948 19 injury injury NN cord-015021-pol2qm74 8948 20 ( ( -LRB- cord-015021-pol2qm74 8948 21 I i NN cord-015021-pol2qm74 8948 22 group group NN cord-015021-pol2qm74 8948 23 . . . cord-015021-pol2qm74 8949 1 22 22 CD cord-015021-pol2qm74 8949 2 patients patient NNS cord-015021-pol2qm74 8949 3 without without IN cord-015021-pol2qm74 8949 4 infectious infectious JJ cord-015021-pol2qm74 8949 5 coz coz NNP cord-015021-pol2qm74 8949 6 ~ ~ CD cord-015021-pol2qm74 8949 7 lications lication NNS cord-015021-pol2qm74 8949 8 and and CC cord-015021-pol2qm74 8949 9 2 2 CD cord-015021-pol2qm74 8949 10 group group NN cord-015021-pol2qm74 8949 11 -53 -53 NNP cord-015021-pol2qm74 8949 12 patients patient NNS cord-015021-pol2qm74 8949 13 with with IN cord-015021-pol2qm74 8949 14 wound wound JJ cord-015021-pol2qm74 8949 15 infections infection NNS cord-015021-pol2qm74 8949 16 development development NN cord-015021-pol2qm74 8949 17 ) ) -RRB- cord-015021-pol2qm74 8949 18 was be VBD cord-015021-pol2qm74 8949 19 carried carry VBN cord-015021-pol2qm74 8949 20 out out RP cord-015021-pol2qm74 8949 21 . . . cord-015021-pol2qm74 8950 1 To to TO cord-015021-pol2qm74 8950 2 restore restore VB cord-015021-pol2qm74 8950 3 found find VBN cord-015021-pol2qm74 8950 4 immunity immunity NN cord-015021-pol2qm74 8950 5 disorders disorder NNS cord-015021-pol2qm74 8950 6 and and CC cord-015021-pol2qm74 8950 7 host host NN cord-015021-pol2qm74 8950 8 defense defense NN cord-015021-pol2qm74 8950 9 to to IN cord-015021-pol2qm74 8950 10 infection infection NN cord-015021-pol2qm74 8950 11 23 23 CD cord-015021-pol2qm74 8950 12 patients patient NNS cord-015021-pol2qm74 8950 13 of of IN cord-015021-pol2qm74 8950 14 the the DT cord-015021-pol2qm74 8950 15 2 2 CD cord-015021-pol2qm74 8950 16 group group NN cord-015021-pol2qm74 8950 17 were be VBD cord-015021-pol2qm74 8950 18 treated treat VBN cord-015021-pol2qm74 8950 19 with with IN cord-015021-pol2qm74 8950 20 Thymalin Thymalin NNP cord-015021-pol2qm74 8950 21 - - , cord-015021-pol2qm74 8950 22 the the DT cord-015021-pol2qm74 8950 23 biologically biologically RB cord-015021-pol2qm74 8950 24 active active JJ cord-015021-pol2qm74 8950 25 peptides peptide NNS cord-015021-pol2qm74 8950 26 prepared prepare VBN cord-015021-pol2qm74 8950 27 from from IN cord-015021-pol2qm74 8950 28 bovine bovine JJ cord-015021-pol2qm74 8950 29 thymus thymus NN cord-015021-pol2qm74 8950 30 . . . cord-015021-pol2qm74 8951 1 The the DT cord-015021-pol2qm74 8951 2 examination examination NN cord-015021-pol2qm74 8951 3 on on IN cord-015021-pol2qm74 8951 4 t t NN cord-015021-pol2qm74 8951 5 ~ ~ NFP cord-015021-pol2qm74 8951 6 e e NN cord-015021-pol2qm74 8951 7 I-3 I-3 NNP cord-015021-pol2qm74 8951 8 days day NNS cord-015021-pol2qm74 8951 9 after after IN cord-015021-pol2qm74 8951 10 injury injury NN cord-015021-pol2qm74 8951 11 revealed reveal VBD cord-015021-pol2qm74 8951 12 a a DT cord-015021-pol2qm74 8951 13 considerable considerable JJ cord-015021-pol2qm74 8951 14 decrease decrease NN cord-015021-pol2qm74 8951 15 of of IN cord-015021-pol2qm74 8951 16 lymphocytes lymphocyte NNS cord-015021-pol2qm74 8951 17 , , , cord-015021-pol2qm74 8951 18 eD3",$D4 eD3",$D4 NNP cord-015021-pol2qm74 8951 19 ~ ~ NFP cord-015021-pol2qm74 8951 20 and and CC cord-015021-pol2qm74 8951 21 CD8 CD8 NNP cord-015021-pol2qm74 8951 22 cells cell NNS cord-015021-pol2qm74 8952 1 amo amo NNP cord-015021-pol2qm74 8953 1 ~it ~it NNS cord-015021-pol2qm74 8953 2 in in IN cord-015021-pol2qm74 8953 3 the the DT cord-015021-pol2qm74 8953 4 blood blood NN cord-015021-pol2qm74 8953 5 , , , cord-015021-pol2qm74 8953 6 CD4 CD4 NNP cord-015021-pol2qm74 8953 7 /CD8 /CD8 : cord-015021-pol2qm74 8953 8 ratio ratio NN cord-015021-pol2qm74 8953 9 and and CC cord-015021-pol2qm74 8953 10 indexes index NNS cord-015021-pol2qm74 8953 11 of of IN cord-015021-pol2qm74 8953 12 let let VB cord-015021-pol2qm74 8953 13 ~ ~ CD cord-015021-pol2qm74 8953 14 ocyte ocyte NNP cord-015021-pol2qm74 8953 15 migration migration NN cord-015021-pol2qm74 8953 16 inhibition inhibition NN cord-015021-pol2qm74 8953 17 test test NN cord-015021-pol2qm74 8953 18 in in IN cord-015021-pol2qm74 8953 19 both both DT cord-015021-pol2qm74 8953 20 groups group NNS cord-015021-pol2qm74 8953 21 of of IN cord-015021-pol2qm74 8953 22 patients patient NNS cord-015021-pol2qm74 8953 23 . . . cord-015021-pol2qm74 8954 1 The the DT cord-015021-pol2qm74 8954 2 imm imm NNP cord-015021-pol2qm74 8954 3 ~ ~ NFP cord-015021-pol2qm74 8954 4 lity lity NN cord-015021-pol2qm74 8954 5 disorders disorder NNS cord-015021-pol2qm74 8954 6 recovered recover VBN cord-015021-pol2qm74 8954 7 to to IN cord-015021-pol2qm74 8954 8 norm norm NN cord-015021-pol2qm74 8954 9 on on IN cord-015021-pol2qm74 8954 10 the the DT cord-015021-pol2qm74 8954 11 7 7 CD cord-015021-pol2qm74 8954 12 - - SYM cord-015021-pol2qm74 8954 13 10 10 CD cord-015021-pol2qm74 8954 14 days day NNS cord-015021-pol2qm74 8954 15 in in IN cord-015021-pol2qm74 8954 16 pateents pateent NNS cord-015021-pol2qm74 8954 17 of+the of+the DT cord-015021-pol2qm74 8954 18 I -PRON- PRP cord-015021-pol2qm74 8954 19 group group NN cord-015021-pol2qm74 8954 20 . . . cord-015021-pol2qm74 8955 1 But but CC cord-015021-pol2qm74 8955 2 stable stable JJ cord-015021-pol2qm74 8955 3 ~eple$ion ~eple$ion NN cord-015021-pol2qm74 8955 4 of of IN cord-015021-pol2qm74 8955 5 CD3 CD3 NNP cord-015021-pol2qm74 8955 6 and and CC cord-015021-pol2qm74 8955 7 CD4 CD4 NNP cord-015021-pol2qm74 8955 8 cells cell NNS cord-015021-pol2qm74 8955 9 amount amount NN cord-015021-pol2qm74 8955 10 , , , cord-015021-pol2qm74 8955 11 lower low JJR cord-015021-pol2qm74 8955 12 CD4 CD4 NNP cord-015021-pol2qm74 8955 13 /CD8 /CD8 , cord-015021-pol2qm74 8955 14 ratio ratio NN cord-015021-pol2qm74 8955 15 and and CC cord-015021-pol2qm74 8955 16 indexes index NNS cord-015021-pol2qm74 8955 17 of of IN cord-015021-pol2qm74 8955 18 leukocyte leukocyte NN cord-015021-pol2qm74 8955 19 migration migration NN cord-015021-pol2qm74 8955 20 inhibition inhibition NN cord-015021-pol2qm74 8955 21 test test NN cord-015021-pol2qm74 8955 22 in in IN cord-015021-pol2qm74 8955 23 patients patient NNS cord-015021-pol2qm74 8955 24 of of IN cord-015021-pol2qm74 8955 25 the the DT cord-015021-pol2qm74 8955 26 2 2 CD cord-015021-pol2qm74 8955 27 group group NN cord-015021-pol2qm74 8955 28 were be VBD cord-015021-pol2qm74 8955 29 observed~ observed~ NNP cord-015021-pol2qm74 8956 1 Besides besides IN cord-015021-pol2qm74 8956 2 that that DT cord-015021-pol2qm74 8956 3 , , , cord-015021-pol2qm74 8956 4 these these DT cord-015021-pol2qm74 8956 5 persons person NNS cord-015021-pol2qm74 8956 6 showed show VBD cord-015021-pol2qm74 8956 7 higher high JJR cord-015021-pol2qm74 8956 8 CD19cells CD19cells NNPS cord-015021-pol2qm74 8956 9 amount amount NN cord-015021-pol2qm74 8956 10 and and CC cord-015021-pol2qm74 8956 11 Ig ig JJ cord-015021-pol2qm74 8956 12 level level NN cord-015021-pol2qm74 8956 13 in in IN cord-015021-pol2qm74 8956 14 the the DT cord-015021-pol2qm74 8956 15 blood blood NN cord-015021-pol2qm74 8956 16 . . . cord-015021-pol2qm74 8957 1 After after IN cord-015021-pol2qm74 8957 2 Thymalin Thymalin NNP cord-015021-pol2qm74 8957 3 therapy therapy NN cord-015021-pol2qm74 8957 4 valid valid JJ cord-015021-pol2qm74 8957 5 ii ii NNP cord-015021-pol2qm74 8957 6 ~ ~ CD cord-015021-pol2qm74 8957 7 rovement rovement NN cord-015021-pol2qm74 8957 8 of of IN cord-015021-pol2qm74 8957 9 inun inun NNS cord-015021-pol2qm74 8957 10 ~ ~ NFP cord-015021-pol2qm74 8957 11 e e NN cord-015021-pol2qm74 8957 12 status status NN cord-015021-pol2qm74 8957 13 was be VBD cord-015021-pol2qm74 8957 14 discovered discover VBN cord-015021-pol2qm74 8957 15 . . . cord-015021-pol2qm74 8958 1 Also also RB cord-015021-pol2qm74 8958 2 good good JJ cord-015021-pol2qm74 8958 3 clinical clinical JJ cord-015021-pol2qm74 8958 4 effect effect NN cord-015021-pol2qm74 8958 5 of of IN cord-015021-pol2qm74 8958 6 immunotherapy immunotherapy NN cord-015021-pol2qm74 8958 7 and and CC cord-015021-pol2qm74 8958 8 best good JJS cord-015021-pol2qm74 8958 9 wo wo NN cord-015021-pol2qm74 8959 1 ~id ~id NNP cord-015021-pol2qm74 8959 2 healing healing NN cord-015021-pol2qm74 8959 3 observed observe VBD cord-015021-pol2qm74 8959 4 in in IN cord-015021-pol2qm74 8959 5 80 80 CD cord-015021-pol2qm74 8959 6 % % NN cord-015021-pol2qm74 8959 7 of of IN cord-015021-pol2qm74 8959 8 cases case NNS cord-015021-pol2qm74 8959 9 . . . cord-015021-pol2qm74 8960 1 These these DT cord-015021-pol2qm74 8960 2 results result NNS cord-015021-pol2qm74 8960 3 allow allow VBP cord-015021-pol2qm74 8960 4 us -PRON- PRP cord-015021-pol2qm74 8960 5 to to TO cord-015021-pol2qm74 8960 6 propose propose VB cord-015021-pol2qm74 8960 7 that that IN cord-015021-pol2qm74 8960 8 the the DT cord-015021-pol2qm74 8960 9 thymus thymus NN cord-015021-pol2qm74 8960 10 involution involution NN cord-015021-pol2qm74 8960 11 and and CC cord-015021-pol2qm74 8960 12 the the DT cord-015021-pol2qm74 8960 13 reduction reduction NN cord-015021-pol2qm74 8960 14 of of IN cord-015021-pol2qm74 8960 15 cell cell NN cord-015021-pol2qm74 8960 16 - - HYPH cord-015021-pol2qm74 8960 17 mediated mediate VBN cord-015021-pol2qm74 8960 18 immunity immunity NN cord-015021-pol2qm74 8960 19 responsiveness responsiveness NN cord-015021-pol2qm74 8960 20 with with IN cord-015021-pol2qm74 8960 21 disturbances disturbance NNS cord-015021-pol2qm74 8960 22 of of IN cord-015021-pol2qm74 8960 23 immu_uoregulatio~ immu_uoregulatio~ NNP cord-015021-pol2qm74 8960 24 on on IN cord-015021-pol2qm74 8960 25 the the DT cord-015021-pol2qm74 8960 26 level level NN cord-015021-pol2qm74 8960 27 of of IN cord-015021-pol2qm74 8960 28 restriction restriction NN cord-015021-pol2qm74 8960 29 of of IN cord-015021-pol2qm74 8960 30 activated activate VBN cord-015021-pol2qm74 8960 31 CD4 CD4 NNP cord-015021-pol2qm74 8960 32 ThO tho NN cord-015021-pol2qm74 8960 33 cells cell NNS cord-015021-pol2qm74 8960 34 play play VBP cord-015021-pol2qm74 8960 35 the the DT cord-015021-pol2qm74 8960 36 most most RBS cord-015021-pol2qm74 8960 37 important important JJ cord-015021-pol2qm74 8960 38 role role NN cord-015021-pol2qm74 8960 39 in in IN cord-015021-pol2qm74 8960 40 the the DT cord-015021-pol2qm74 8960 41 pathogenesis pathogenesis NN cord-015021-pol2qm74 8960 42 of of IN cord-015021-pol2qm74 8960 43 wound wound JJ cord-015021-pol2qm74 8960 44 infections infection NNS cord-015021-pol2qm74 8960 45 development development NN cord-015021-pol2qm74 8960 46 in in IN cord-015021-pol2qm74 8960 47 persons person NNS cord-015021-pol2qm74 8960 48 with with IN cord-015021-pol2qm74 8960 49 traumatic traumatic JJ cord-015021-pol2qm74 8960 50 injury injury NN cord-015021-pol2qm74 8960 51 . . . cord-015021-pol2qm74 8961 1 Dept Dept NNP cord-015021-pol2qm74 8961 2 . . . cord-015021-pol2qm74 8962 1 of of IN cord-015021-pol2qm74 8962 2 Immunology Immunology NNP cord-015021-pol2qm74 8962 3 , , , cord-015021-pol2qm74 8962 4 Military Military NNP cord-015021-pol2qm74 8962 5 - - HYPH cord-015021-pol2qm74 8962 6 Nedical Nedical NNP cord-015021-pol2qm74 8962 7 Academy Academy NNP cord-015021-pol2qm74 8962 8 , , , cord-015021-pol2qm74 8962 9 Lebedeva Lebedeva NNP cord-015021-pol2qm74 8962 10 Str Str NNP cord-015021-pol2qm74 8962 11 . . NNP cord-015021-pol2qm74 8962 12 6 6 CD cord-015021-pol2qm74 8962 13 , , , cord-015021-pol2qm74 8962 14 194175 194175 CD cord-015021-pol2qm74 8962 15 , , , cord-015021-pol2qm74 8962 16 St St NNP cord-015021-pol2qm74 8962 17 . . NNP cord-015021-pol2qm74 8962 18 Petersburg Petersburg NNP cord-015021-pol2qm74 8962 19 , , , cord-015021-pol2qm74 8962 20 Russia Russia NNP cord-015021-pol2qm74 8962 21 A a DT cord-015021-pol2qm74 8962 22 severe severe JJ cord-015021-pol2qm74 8962 23 Impairment impairment NN cord-015021-pol2qm74 8962 24 of of IN cord-015021-pol2qm74 8962 25 neutrophil neutrophil NN cord-015021-pol2qm74 8962 26 ( ( -LRB- cord-015021-pol2qm74 8962 27 PMN pmn NN cord-015021-pol2qm74 8962 28 ) ) -RRB- cord-015021-pol2qm74 8962 29 function function NN cord-015021-pol2qm74 8962 30 often often RB cord-015021-pol2qm74 8962 31 occurs occur VBZ cord-015021-pol2qm74 8962 32 following follow VBG cord-015021-pol2qm74 8962 33 severe severe JJ cord-015021-pol2qm74 8962 34 thermal thermal JJ cord-015021-pol2qm74 8962 35 or or CC cord-015021-pol2qm74 8962 36 non non JJ cord-015021-pol2qm74 8962 37 - - JJ cord-015021-pol2qm74 8962 38 thermal thermal JJ cord-015021-pol2qm74 8962 39 traumatic traumatic JJ cord-015021-pol2qm74 8962 40 Injury injury NN cord-015021-pol2qm74 8962 41 . . . cord-015021-pol2qm74 8963 1 Our -PRON- PRP$ cord-015021-pol2qm74 8963 2 laboratory laboratory NN cord-015021-pol2qm74 8963 3 has have VBZ cord-015021-pol2qm74 8963 4 previously previously RB cord-015021-pol2qm74 8963 5 reported report VBN cord-015021-pol2qm74 8963 6 that that IN cord-015021-pol2qm74 8963 7 following follow VBG cord-015021-pol2qm74 8963 8 severe severe JJ cord-015021-pol2qm74 8963 9 burn burn NN cord-015021-pol2qm74 8963 10 or or CC cord-015021-pol2qm74 8963 11 non non JJ cord-015021-pol2qm74 8963 12 - - JJ cord-015021-pol2qm74 8963 13 burn burn JJ cord-015021-pol2qm74 8963 14 traumatic traumatic JJ cord-015021-pol2qm74 8963 15 injury injury NN cord-015021-pol2qm74 8963 16 the the DT cord-015021-pol2qm74 8963 17 expression expression NN cord-015021-pol2qm74 8963 18 of of IN cord-015021-pol2qm74 8963 19 the the DT cord-015021-pol2qm74 8963 20 p2 p2 NNP cord-015021-pol2qm74 8963 21 Integrlns Integrlns NNP cord-015021-pol2qm74 8963 22 ( ( -LRB- cord-015021-pol2qm74 8963 23 CD11a CD11a NNS cord-015021-pol2qm74 8963 24 , , , cord-015021-pol2qm74 8963 25 b b NN cord-015021-pol2qm74 8963 26 , , , cord-015021-pol2qm74 8963 27 c c NNP cord-015021-pol2qm74 8963 28 / / SYM cord-015021-pol2qm74 8963 29 CD18 CD18 NNP cord-015021-pol2qm74 8963 30 ) ) -RRB- cord-015021-pol2qm74 8963 31 and and CC cord-015021-pol2qm74 8963 32 the the DT cord-015021-pol2qm74 8963 33 FW FW NNP cord-015021-pol2qm74 8963 34 receptors receptor NNS cord-015021-pol2qm74 8963 35 ( ( -LRB- cord-015021-pol2qm74 8963 36 CD16 CD16 NNP cord-015021-pol2qm74 8963 37 , , , cord-015021-pol2qm74 8963 38 and and CC cord-015021-pol2qm74 8963 39 CD32 CD32 NNP cord-015021-pol2qm74 8963 40 ) ) -RRB- cord-015021-pol2qm74 8963 41 were be VBD cord-015021-pol2qm74 8963 42 significantly significantly RB cord-015021-pol2qm74 8963 43 decreased decrease VBN cord-015021-pol2qm74 8963 44 on on IN cord-015021-pol2qm74 8963 45 PMNs pmn NNS cord-015021-pol2qm74 8963 46 , , , cord-015021-pol2qm74 8963 47 In in IN cord-015021-pol2qm74 8963 48 this this DT cord-015021-pol2qm74 8963 49 study study NN cord-015021-pol2qm74 8963 50 , , , cord-015021-pol2qm74 8963 51 the the DT cord-015021-pol2qm74 8963 52 effects effect NNS cord-015021-pol2qm74 8963 53 of of IN cord-015021-pol2qm74 8963 54 GM GM NNP cord-015021-pol2qm74 8963 55 and and CC cord-015021-pol2qm74 8963 56 G G NNP cord-015021-pol2qm74 8963 57 - - HYPH cord-015021-pol2qm74 8963 58 CSF CSF NNP cord-015021-pol2qm74 8963 59 on on IN cord-015021-pol2qm74 8963 60 the the DT cord-015021-pol2qm74 8963 61 expression expression NN cord-015021-pol2qm74 8963 62 of of IN cord-015021-pol2qm74 8963 63 the the DT cord-015021-pol2qm74 8963 64 F~ F~ NNP cord-015021-pol2qm74 8963 65 R R NNP cord-015021-pol2qm74 8963 66 and and CC cord-015021-pol2qm74 8963 67 the the DT cord-015021-pol2qm74 8963 68 ~2 ~2 CD cord-015021-pol2qm74 8963 69 Integrln Integrln NNP cord-015021-pol2qm74 8963 70 family family NN cord-015021-pol2qm74 8963 71 on on IN cord-015021-pol2qm74 8963 72 PMNs pmn NNS cord-015021-pol2qm74 8963 73 were be VBD cord-015021-pol2qm74 8963 74 examined examine VBN cord-015021-pol2qm74 8963 75 , , , cord-015021-pol2qm74 8963 76 PMNs pmn NNS cord-015021-pol2qm74 8963 77 were be VBD cord-015021-pol2qm74 8963 78 obtained obtain VBN cord-015021-pol2qm74 8963 79 from from IN cord-015021-pol2qm74 8963 80 severe severe JJ cord-015021-pol2qm74 8963 81 trauma trauma NN cord-015021-pol2qm74 8963 82 ( ( -LRB- cord-015021-pol2qm74 8963 83 initial initial JJ cord-015021-pol2qm74 8963 84 APACHE APACHE NNP cord-015021-pol2qm74 8963 85 II II NNP cord-015021-pol2qm74 8963 86 score score NN cord-015021-pol2qm74 8963 87 ; ; : cord-015021-pol2qm74 8963 88 z z CD cord-015021-pol2qm74 8963 89 10 10 CD cord-015021-pol2qm74 8963 90 ) ) -RRB- cord-015021-pol2qm74 8963 91 or or CC cord-015021-pol2qm74 8963 92 thermal thermal JJ cord-015021-pol2qm74 8963 93 injury injury NN cord-015021-pol2qm74 8963 94 ( ( -LRB- cord-015021-pol2qm74 8963 95 > > NFP cord-015021-pol2qm74 8963 96 30~ 30~ CD cord-015021-pol2qm74 8963 97 ; ; : cord-015021-pol2qm74 8963 98 total total JJ cord-015021-pol2qm74 8963 99 body body NN cord-015021-pol2qm74 8963 100 surface surface NN cord-015021-pol2qm74 8963 101 area area NN cord-015021-pol2qm74 8963 102 , , , cord-015021-pol2qm74 8963 103 > > XX cord-015021-pol2qm74 8963 104 15~ 15~ CD cord-015021-pol2qm74 8963 105 full full JJ cord-015021-pol2qm74 8963 106 thickness thickness NN cord-015021-pol2qm74 8963 107 ) ) -RRB- cord-015021-pol2qm74 8963 108 and and CC cord-015021-pol2qm74 8963 109 Incubated incubate VBN cord-015021-pol2qm74 8963 110 /n /n NNP cord-015021-pol2qm74 8963 111 v v NN cord-015021-pol2qm74 8963 112 / / SYM cord-015021-pol2qm74 8963 113 tro tro NN cord-015021-pol2qm74 8963 114 with with IN cord-015021-pol2qm74 8963 115 GM GM NNP cord-015021-pol2qm74 8963 116 or or CC cord-015021-pol2qm74 8963 117 G G NNP cord-015021-pol2qm74 8963 118 - - HYPH cord-015021-pol2qm74 8963 119 CSF CSF NNP cord-015021-pol2qm74 8963 120 . . . cord-015021-pol2qm74 8964 1 The the DT cord-015021-pol2qm74 8964 2 J32 J32 NNP cord-015021-pol2qm74 8964 3 integrins integrin NNS cord-015021-pol2qm74 8964 4 or or CC cord-015021-pol2qm74 8964 5 FcyR FcyR NNP cord-015021-pol2qm74 8964 6 were be VBD cord-015021-pol2qm74 8964 7 detected detect VBN cord-015021-pol2qm74 8964 8 with with IN cord-015021-pol2qm74 8964 9 monoclonal monoclonal JJ cord-015021-pol2qm74 8964 10 antibodies antibody NNS cord-015021-pol2qm74 8964 11 and and CC cord-015021-pol2qm74 8964 12 flow flow NN cord-015021-pol2qm74 8964 13 cytometry cytometry NN cord-015021-pol2qm74 8964 14 . . . cord-015021-pol2qm74 8965 1 GM GM NNP cord-015021-pol2qm74 8965 2 end end NN cord-015021-pol2qm74 8966 1 G G NNP cord-015021-pol2qm74 8966 2 - - HYPH cord-015021-pol2qm74 8966 3 CSF CSF NNP cord-015021-pol2qm74 8966 4 Induced induce VBD cord-015021-pol2qm74 8966 5 a a DT cord-015021-pol2qm74 8966 6 sllght sllght NN cord-015021-pol2qm74 8966 7 increase increase NN cord-015021-pol2qm74 8967 1 In in IN cord-015021-pol2qm74 8967 2 the the DT cord-015021-pol2qm74 8967 3 percentage percentage NN cord-015021-pol2qm74 8967 4 of of IN cord-015021-pol2qm74 8967 5 PMNs pmn NNS cord-015021-pol2qm74 8967 6 expressing express VBG cord-015021-pol2qm74 8967 7 CD1 CD1 NNP cord-015021-pol2qm74 8967 8 lb lb NNP cord-015021-pol2qm74 8967 9 , , , cord-015021-pol2qm74 8967 10 CD16 CD16 NNP cord-015021-pol2qm74 8967 11 , , , cord-015021-pol2qm74 8967 12 and and CC cord-015021-pol2qm74 8967 13 CD18 CD18 NNP cord-015021-pol2qm74 8967 14 while while IN cord-015021-pol2qm74 8967 15 GM GM NNP cord-015021-pol2qm74 8967 16 bur bur NN cord-015021-pol2qm74 8967 17 not not RB cord-015021-pol2qm74 8967 18 C C NNP cord-015021-pol2qm74 8967 19 - - HYPH cord-015021-pol2qm74 8967 20 CSF CSF NNP cord-015021-pol2qm74 8967 21 Induced induce VBD cord-015021-pol2qm74 8967 22 an an DT cord-015021-pol2qm74 8967 23 Increase increase NN cord-015021-pol2qm74 8967 24 in in IN cord-015021-pol2qm74 8967 25 the the DT cord-015021-pol2qm74 8967 26 percentage percentage NN cord-015021-pol2qm74 8967 27 expressing express VBG cord-015021-pol2qm74 8967 28 CDI CDI NNP cord-015021-pol2qm74 8967 29 1 1 CD cord-015021-pol2qm74 8967 30 a a NNP cord-015021-pol2qm74 8967 31 , , , cord-015021-pol2qm74 8967 32 CD1 CD1 NNP cord-015021-pol2qm74 8967 33 lc lc NNP cord-015021-pol2qm74 8967 34 , , , cord-015021-pol2qm74 8967 35 and and CC cord-015021-pol2qm74 8967 36 CD32 CD32 NNP cord-015021-pol2qm74 8967 37 , , , cord-015021-pol2qm74 8967 38 GM GM NNP cord-015021-pol2qm74 8967 39 - - HYPH cord-015021-pol2qm74 8967 40 CSF CSF NNP cord-015021-pol2qm74 8967 41 and and CC cord-015021-pol2qm74 8967 42 to to IN cord-015021-pol2qm74 8967 43 a a DT cord-015021-pol2qm74 8967 44 lesser less JJR cord-015021-pol2qm74 8967 45 extent extent NN cord-015021-pol2qm74 8967 46 G G NNP cord-015021-pol2qm74 8967 47 - - HYPH cord-015021-pol2qm74 8967 48 CSF CSF NNP cord-015021-pol2qm74 8967 49 Induced induce VBD cord-015021-pol2qm74 8967 50 an an DT cord-015021-pol2qm74 8967 51 increase increase NN cord-015021-pol2qm74 8967 52 in in IN cord-015021-pol2qm74 8967 53 the the DT cord-015021-pol2qm74 8967 54 density density NN cord-015021-pol2qm74 8967 55 ( ( -LRB- cord-015021-pol2qm74 8967 56 1,5 1,5 CD cord-015021-pol2qm74 8967 57 fold fold NN cord-015021-pol2qm74 8967 58 ) ) -RRB- cord-015021-pol2qm74 8967 59 of of IN cord-015021-pol2qm74 8967 60 the the DT cord-015021-pol2qm74 8967 61 ~2 ~2 NNP cord-015021-pol2qm74 8967 62 integrlns integrlns NNPS cord-015021-pol2qm74 8967 63 on on IN cord-015021-pol2qm74 8967 64 PMNs pmn NNS cord-015021-pol2qm74 8967 65 from from IN cord-015021-pol2qm74 8967 66 normal normal JJ cord-015021-pol2qm74 8967 67 , , , cord-015021-pol2qm74 8967 68 burn burn VB cord-015021-pol2qm74 8967 69 , , , cord-015021-pol2qm74 8967 70 and and CC cord-015021-pol2qm74 8967 71 trauma trauma NN cord-015021-pol2qm74 8967 72 patients patient NNS cord-015021-pol2qm74 8967 73 , , , cord-015021-pol2qm74 8967 74 These these DT cord-015021-pol2qm74 8967 75 data datum NNS cord-015021-pol2qm74 8967 76 suggest suggest VBP cord-015021-pol2qm74 8967 77 that that IN cord-015021-pol2qm74 8967 78 cytoklne cytoklne JJ cord-015021-pol2qm74 8967 79 modulation modulation NN cord-015021-pol2qm74 8967 80 with with IN cord-015021-pol2qm74 8967 81 CSFs csf NNS cord-015021-pol2qm74 8967 82 could could MD cord-015021-pol2qm74 8967 83 have have VB cord-015021-pol2qm74 8967 84 a a DT cord-015021-pol2qm74 8967 85 role role NN cord-015021-pol2qm74 8967 86 clinically clinically RB cord-015021-pol2qm74 8967 87 in in IN cord-015021-pol2qm74 8967 88 certain certain JJ cord-015021-pol2qm74 8967 89 situations situation NNS cord-015021-pol2qm74 8967 90 . . . cord-015021-pol2qm74 8968 1 Institute Institute NNP cord-015021-pol2qm74 8968 2 , , , cord-015021-pol2qm74 8968 3 Dept Dept NNP cord-015021-pol2qm74 8968 4 . . NNP cord-015021-pol2qm74 8968 5 of of IN cord-015021-pol2qm74 8968 6 Surgery surgery NN cord-015021-pol2qm74 8968 7 , , , cord-015021-pol2qm74 8968 8 231 231 CD cord-015021-pol2qm74 8968 9 Bethesda Bethesda NNP cord-015021-pol2qm74 8968 10 Ave Ave NNP cord-015021-pol2qm74 8968 11 , , , cord-015021-pol2qm74 8968 12 Cincinnati Cincinnati NNP cord-015021-pol2qm74 8968 13 , , , cord-015021-pol2qm74 8968 14 OH oh UH cord-015021-pol2qm74 8968 15 , , , cord-015021-pol2qm74 8968 16 USA USA NNP cord-015021-pol2qm74 8968 17 , , , cord-015021-pol2qm74 8968 18 45267 45267 CD cord-015021-pol2qm74 8968 19 - - SYM cord-015021-pol2qm74 8968 20 0558 0558 CD cord-015021-pol2qm74 8968 21 . . . cord-015021-pol2qm74 8969 1 Funl Funl NNS cord-015021-pol2qm74 8969 2 ~ ~ NFP cord-015021-pol2qm74 8969 3 al al NNP cord-015021-pol2qm74 8969 4 Infections Infections NNPS cord-015021-pol2qm74 8969 5 after after IN cord-015021-pol2qm74 8969 6 Solid Solid NNP cord-015021-pol2qm74 8969 7 Organ Organ NNP cord-015021-pol2qm74 8969 8 Transplantatlon(SOT Transplantatlon(SOT NNP cord-015021-pol2qm74 8969 9 ) ) -RRB- cord-015021-pol2qm74 8970 1 Lewis Lewis NNP cord-015021-pol2qm74 8970 2 Flint Flint NNP cord-015021-pol2qm74 8970 3 , , , cord-015021-pol2qm74 8970 4 MD MD NNP cord-015021-pol2qm74 8970 5 and and CC cord-015021-pol2qm74 8970 6 Ed,~-afd Ed,~-afd NNP cord-015021-pol2qm74 8970 7 E. E. NNP cord-015021-pol2qm74 8970 8 Etheredge Etheredge NNP cord-015021-pol2qm74 8970 9 , , , cord-015021-pol2qm74 8970 10 ME ME NNP cord-015021-pol2qm74 8970 11 ) ) -RRB- cord-015021-pol2qm74 8970 12 Dept Dept NNP cord-015021-pol2qm74 8970 13 . . NNP cord-015021-pol2qm74 8970 14 of of IN cord-015021-pol2qm74 8970 15 Surgery surgery NN cord-015021-pol2qm74 8970 16 Tullrte Tullrte NNP cord-015021-pol2qm74 8970 17 Univ Univ NNP cord-015021-pol2qm74 8970 18 . . . cord-015021-pol2qm74 8971 1 School School NNP cord-015021-pol2qm74 8971 2 of of IN cord-015021-pol2qm74 8971 3 Medicine Medicine NNP cord-015021-pol2qm74 8971 4 New New NNP cord-015021-pol2qm74 8971 5 Orleans Orleans NNP cord-015021-pol2qm74 8971 6 . . . cord-015021-pol2qm74 8972 1 Louisiana Louisiana NNP cord-015021-pol2qm74 8972 2 Infections Infections NNPS cord-015021-pol2qm74 8972 3 contribute contribute VBP cord-015021-pol2qm74 8972 4 to to IN cord-015021-pol2qm74 8972 5 increased increase VBN cord-015021-pol2qm74 8972 6 gra5 gra5 NNP cord-015021-pol2qm74 8972 7 loss loss NN cord-015021-pol2qm74 8972 8 and and CC cord-015021-pol2qm74 8972 9 mortaliw mortaliw NN cord-015021-pol2qm74 8972 10 following follow VBG cord-015021-pol2qm74 8972 11 SOT SOT NNP cord-015021-pol2qm74 8972 12 . . . cord-015021-pol2qm74 8973 1 Pr Pr NNP cord-015021-pol2qm74 8974 1 ~isposing ~ispose VBG cord-015021-pol2qm74 8974 2 facton facton NN cord-015021-pol2qm74 8974 3 include include VBP cord-015021-pol2qm74 8974 4 diabetes diabetes NN cord-015021-pol2qm74 8974 5 , , , cord-015021-pol2qm74 8974 6 hepatitis hepatitis NN cord-015021-pol2qm74 8974 7 , , , cord-015021-pol2qm74 8974 8 leukopenia leukopenia NNP cord-015021-pol2qm74 8974 9 , , , cord-015021-pol2qm74 8974 10 cc.¢xistem cc.¢xistem CD cord-015021-pol2qm74 8974 11 infection infection NN cord-015021-pol2qm74 8974 12 , , , cord-015021-pol2qm74 8974 13 and and CC cord-015021-pol2qm74 8974 14 intense intense JJ cord-015021-pol2qm74 8974 15 , , , cord-015021-pol2qm74 8974 16 especially especially RB cord-015021-pol2qm74 8974 17 triple triple JJ cord-015021-pol2qm74 8974 18 drug drug NN cord-015021-pol2qm74 8974 19 , , , cord-015021-pol2qm74 8974 20 immunosuppression immunosuppression NN cord-015021-pol2qm74 8974 21 . . . cord-015021-pol2qm74 8975 1 Funga Funga NNP cord-015021-pol2qm74 8975 2 ] ] -RRB- cord-015021-pol2qm74 8975 3 infections infection NNS cord-015021-pol2qm74 8975 4 occur occur VBP cord-015021-pol2qm74 8976 1 ~s ~s NNP cord-015021-pol2qm74 8976 2 isolated isolated JJ cord-015021-pol2qm74 8976 3 conditions condition NNS cord-015021-pol2qm74 8976 4 in in IN cord-015021-pol2qm74 8976 5 6 6 CD cord-015021-pol2qm74 8976 6 % % NN cord-015021-pol2qm74 8976 7 and and CC cord-015021-pol2qm74 8976 8 in in IN cord-015021-pol2qm74 8976 9 association association NN cord-015021-pol2qm74 8976 10 with with IN cord-015021-pol2qm74 8976 11 bacterial bacterial JJ cord-015021-pol2qm74 8976 12 infection(l infection(l NNP cord-015021-pol2qm74 8976 13 1 1 CD cord-015021-pol2qm74 8976 14 % % NN cord-015021-pol2qm74 8976 15 ) ) -RRB- cord-015021-pol2qm74 8976 16 , , , cord-015021-pol2qm74 8976 17 viral viral JJ cord-015021-pol2qm74 8976 18 infection(3*/. infection(3*/. NNP cord-015021-pol2qm74 8976 19 ) ) -RRB- cord-015021-pol2qm74 8976 20 , , , cord-015021-pol2qm74 8976 21 and and CC cord-015021-pol2qm74 8976 22 combined combine VBN cord-015021-pol2qm74 8976 23 infections(It% infections(It% NNS cord-015021-pol2qm74 8976 24 ) ) -RRB- cord-015021-pol2qm74 8976 25 , , , cord-015021-pol2qm74 8976 26 Candida Candida NNP cord-015021-pol2qm74 8976 27 sp sp NN cord-015021-pol2qm74 8976 28 . . . cord-015021-pol2qm74 8977 1 is be VBZ cord-015021-pol2qm74 8977 2 the the DT cord-015021-pol2qm74 8977 3 most most RBS cord-015021-pol2qm74 8977 4 common common JJ cord-015021-pol2qm74 8977 5 fungus fungus NN cord-015021-pol2qm74 8977 6 recovered recover VBN cord-015021-pol2qm74 8977 7 but but CC cord-015021-pol2qm74 8977 8 Aspecgillus Aspecgillus NNP cord-015021-pol2qm74 8977 9 , , , cord-015021-pol2qm74 8977 10 Coccidiodies Coccidiodies NNP cord-015021-pol2qm74 8977 11 , , , cord-015021-pol2qm74 8977 12 Cryptococcus Cryptococcus NNP cord-015021-pol2qm74 8977 13 , , , cord-015021-pol2qm74 8977 14 Histoplasma Histoplasma NNP cord-015021-pol2qm74 8977 15 , , , cord-015021-pol2qm74 8978 1 Mueor~ mueor~ CD cord-015021-pol2qm74 8979 1 ghizopus ghizopus NNP cord-015021-pol2qm74 8979 2 , , , cord-015021-pol2qm74 8979 3 Tinea Tinea NNP cord-015021-pol2qm74 8979 4 , , , cord-015021-pol2qm74 8979 5 and and CC cord-015021-pol2qm74 8979 6 ToruIop ToruIop NNP cord-015021-pol2qm74 8980 1 ~is ~is NNP cord-015021-pol2qm74 8980 2 s s NNP cord-015021-pol2qm74 8980 3 ? ? . cord-015021-pol2qm74 8980 4 . . . cord-015021-pol2qm74 8981 1 also also RB cord-015021-pol2qm74 8981 2 are be VBP cord-015021-pol2qm74 8981 3 pathogens pathogen NNS cord-015021-pol2qm74 8981 4 . . . cord-015021-pol2qm74 8982 1 Clinical clinical JJ cord-015021-pol2qm74 8982 2 syndromes syndrome NNS cord-015021-pol2qm74 8982 3 vary vary VBP cord-015021-pol2qm74 8982 4 among among IN cord-015021-pol2qm74 8982 5 orga.aizms orga.aizms JJ cord-015021-pol2qm74 8982 6 or or CC cord-015021-pol2qm74 8982 7 may may MD cord-015021-pol2qm74 8982 8 be be VB cord-015021-pol2qm74 8982 9 variable variable JJ cord-015021-pol2qm74 8982 10 with with IN cord-015021-pol2qm74 8982 11 a a DT cord-015021-pol2qm74 8982 12 single single JJ cord-015021-pol2qm74 8982 13 p p NN cord-015021-pol2qm74 8982 14 ~ ~ CD cord-015021-pol2qm74 8982 15 tthogen tthogen NNP cord-015021-pol2qm74 8982 16 , , , cord-015021-pol2qm74 8982 17 For for IN cord-015021-pol2qm74 8982 18 ~ample ~ample NNP cord-015021-pol2qm74 8982 19 , , , cord-015021-pol2qm74 8982 20 with with IN cord-015021-pol2qm74 8982 21 aggressive aggressive JJ cord-015021-pol2qm74 8982 22 immunosuppression immunosuppression NN cord-015021-pol2qm74 8982 23 , , , cord-015021-pol2qm74 8983 1 Candlda Candlda NNP cord-015021-pol2qm74 8983 2 my -PRON- PRP$ cord-015021-pol2qm74 8983 3 be be VB cord-015021-pol2qm74 8983 4 localized localize VBN cord-015021-pol2qm74 8983 5 esophagitis esophagitis NN cord-015021-pol2qm74 8983 6 or or CC cord-015021-pol2qm74 8983 7 cystitis cystitis NN cord-015021-pol2qm74 8983 8 or or CC cord-015021-pol2qm74 8983 9 systemically systemically RB cord-015021-pol2qm74 8983 10 iavaslve iavaslve VB cord-015021-pol2qm74 8983 11 with with IN cord-015021-pol2qm74 8983 12 an an DT cord-015021-pol2qm74 8983 13 associated associated JJ cord-015021-pol2qm74 8983 14 high high JJ cord-015021-pol2qm74 8983 15 mortality mortality NN cord-015021-pol2qm74 8983 16 . . . cord-015021-pol2qm74 8984 1 AspergilIus AspergilIus NNP cord-015021-pol2qm74 8984 2 presents present VBZ cord-015021-pol2qm74 8984 3 ~ ~ NFP cord-015021-pol2qm74 8984 4 a a DT cord-015021-pol2qm74 8984 5 diffuse diffuse JJ cord-015021-pol2qm74 8984 6 pneumonia pneumonia NN cord-015021-pol2qm74 8984 7 while while IN cord-015021-pol2qm74 8984 8 Cryptococcus Cryptococcus NNP cord-015021-pol2qm74 8984 9 causes cause VBZ cord-015021-pol2qm74 8984 10 pulmonary pulmonary NN cord-015021-pol2qm74 8984 11 and and CC cord-015021-pol2qm74 8984 12 centrad centrad NN cord-015021-pol2qm74 8984 13 nervons nervon VBZ cord-015021-pol2qm74 8984 14 sy'Stem sy'stem CD cord-015021-pol2qm74 8984 15 infection infection NN cord-015021-pol2qm74 8984 16 , , , cord-015021-pol2qm74 8984 17 Clinical clinical JJ cord-015021-pol2qm74 8984 18 examination examination NN cord-015021-pol2qm74 8984 19 , , , cord-015021-pol2qm74 8984 20 CT CT NNP cord-015021-pol2qm74 8984 21 scanning scanning NN cord-015021-pol2qm74 8984 22 and and CC cord-015021-pol2qm74 8984 23 aggressive aggressive JJ cord-015021-pol2qm74 8984 24 sampling sampling NN cord-015021-pol2qm74 8984 25 for for IN cord-015021-pol2qm74 8984 26 c'ultures c'ultures NNP cord-015021-pol2qm74 8984 27 a.s a.s NNP cord-015021-pol2qm74 8984 28 wall wall NN cord-015021-pol2qm74 8984 29 as as IN cord-015021-pol2qm74 8984 30 serologic serologic NNP cord-015021-pol2qm74 8984 31 tests test NNS cord-015021-pol2qm74 8984 32 contribute contribute VBP cord-015021-pol2qm74 8984 33 to to IN cord-015021-pol2qm74 8984 34 diagnosis diagnosis NN cord-015021-pol2qm74 8984 35 . . . cord-015021-pol2qm74 8985 1 Empiric empiric RB cord-015021-pol2qm74 8985 2 the the DT cord-015021-pol2qm74 8986 1 ~py ~py NNP cord-015021-pol2qm74 8986 2 is be VBZ cord-015021-pol2qm74 8986 3 ind',cated ind',cate VBN cord-015021-pol2qm74 8986 4 where where WRB cord-015021-pol2qm74 8986 5 there there EX cord-015021-pol2qm74 8986 6 is be VBZ cord-015021-pol2qm74 8986 7 a a DT cord-015021-pol2qm74 8986 8 high high JJ cord-015021-pol2qm74 8986 9 level level NN cord-015021-pol2qm74 8986 10 of of IN cord-015021-pol2qm74 8986 11 suspicion suspicion NN cord-015021-pol2qm74 8986 12 . . . cord-015021-pol2qm74 8987 1 Preventlon Preventlon NNP cord-015021-pol2qm74 8987 2 of of IN cord-015021-pol2qm74 8987 3 Ca.adlda ca.adlda CD cord-015021-pol2qm74 8987 4 izfection izfection NN cord-015021-pol2qm74 8987 5 is be VBZ cord-015021-pol2qm74 8987 6 ~ci ~ci NNP cord-015021-pol2qm74 8987 7 ~ ~ NFP cord-015021-pol2qm74 8987 8 itated itate VBN cord-015021-pol2qm74 8987 9 by by IN cord-015021-pol2qm74 8987 10 early early JJ cord-015021-pol2qm74 8987 11 remov remov NN cord-015021-pol2qm74 8987 12 - - HYPH cord-015021-pol2qm74 8987 13 a.1 a.1 CD cord-015021-pol2qm74 8987 14 of of IN cord-015021-pol2qm74 8987 15 central central JJ cord-015021-pol2qm74 8987 16 } } -RRB- cord-015021-pol2qm74 8987 17 ants ant NNS cord-015021-pol2qm74 8987 18 , , , cord-015021-pol2qm74 8987 19 ca ca NNP cord-015021-pol2qm74 8987 20 ~ ~ CD cord-015021-pol2qm74 8987 21 hetess hetess NN cord-015021-pol2qm74 8987 22 and and CC cord-015021-pol2qm74 8987 23 stents stent NNS cord-015021-pol2qm74 8987 24 as as RB cord-015021-pol2qm74 8987 25 well well RB cord-015021-pol2qm74 8987 26 as as IN cord-015021-pol2qm74 8987 27 by by IN cord-015021-pol2qm74 8987 28 the the DT cord-015021-pol2qm74 8987 29 use use NN cord-015021-pol2qm74 8987 30 of of IN cord-015021-pol2qm74 8987 31 oral oral JJ cord-015021-pol2qm74 8987 32 nystatin nystatin NNS cord-015021-pol2qm74 8987 33 . . . cord-015021-pol2qm74 8988 1 Amphotericin Amphotericin NNP cord-015021-pol2qm74 8988 2 ] ] -RRB- cord-015021-pol2qm74 8988 3 ~ ~ NFP cord-015021-pol2qm74 8988 4 remains remain VBZ cord-015021-pol2qm74 8988 5 the the DT cord-015021-pol2qm74 8988 6 drug drug NN cord-015021-pol2qm74 8988 7 of of IN cord-015021-pol2qm74 8988 8 choice choice NN cord-015021-pol2qm74 8988 9 for for IN cord-015021-pol2qm74 8988 10 treatment treatment NN cord-015021-pol2qm74 8988 11 of of IN cord-015021-pol2qm74 8988 12 in.save in.save NNP cord-015021-pol2qm74 8988 13 fungd fungd NN cord-015021-pol2qm74 8988 14 infection infection NN cord-015021-pol2qm74 8988 15 , , , cord-015021-pol2qm74 8988 16 Surgical surgical JJ cord-015021-pol2qm74 8988 17 resection resection NN cord-015021-pol2qm74 8988 18 of of IN cord-015021-pol2qm74 8988 19 infectious infectious JJ cord-015021-pol2qm74 8988 20 loci locus NNS cord-015021-pol2qm74 8988 21 in in IN cord-015021-pol2qm74 8988 22 the the DT cord-015021-pol2qm74 8988 23 lung lung NN cord-015021-pol2qm74 8988 24 and and CC cord-015021-pol2qm74 8988 25 brain brain NN cord-015021-pol2qm74 8988 26 is be VBZ cord-015021-pol2qm74 8988 27 indicated indicate VBN cord-015021-pol2qm74 8988 28 in in IN cord-015021-pol2qm74 8988 29 selected select VBN cord-015021-pol2qm74 8988 30 patientS. patients. NN cord-015021-pol2qm74 8989 1 The the DT cord-015021-pol2qm74 8989 2 main main JJ cord-015021-pol2qm74 8989 3 problems problem NNS cord-015021-pol2qm74 8989 4 of of IN cord-015021-pol2qm74 8989 5 diagnosis diagnosis NN cord-015021-pol2qm74 8989 6 in in IN cord-015021-pol2qm74 8989 7 lower low JJR cord-015021-pol2qm74 8989 8 respirator- respirator- NNS cord-015021-pol2qm74 8989 9 ) ) -RRB- cord-015021-pol2qm74 8989 10 , , , cord-015021-pol2qm74 8989 11 tract tract JJ cord-015021-pol2qm74 8989 12 infection infection NN cord-015021-pol2qm74 8989 13 are be VBP cord-015021-pol2qm74 8989 14 the the DT cord-015021-pol2qm74 8989 15 differentation differentation NN cord-015021-pol2qm74 8989 16 of of IN cord-015021-pol2qm74 8989 17 infection infection NN cord-015021-pol2qm74 8989 18 from from IN cord-015021-pol2qm74 8989 19 colonization colonization NN cord-015021-pol2qm74 8989 20 or or CC cord-015021-pol2qm74 8989 21 contamination contamination NN cord-015021-pol2qm74 8989 22 , , , cord-015021-pol2qm74 8989 23 and and CC cord-015021-pol2qm74 8989 24 the the DT cord-015021-pol2qm74 8989 25 isolation isolation NN cord-015021-pol2qm74 8989 26 of of IN cord-015021-pol2qm74 8989 27 a a DT cord-015021-pol2qm74 8989 28 reliable reliable JJ cord-015021-pol2qm74 8989 29 and and CC cord-015021-pol2qm74 8989 30 true true JJ cord-015021-pol2qm74 8989 31 pathogen pathogen NN cord-015021-pol2qm74 8989 32 . . . cord-015021-pol2qm74 8990 1 Expectorated expectorated JJ cord-015021-pol2qm74 8990 2 sputum sputum NN cord-015021-pol2qm74 8990 3 may may MD cord-015021-pol2qm74 8990 4 be be VB cord-015021-pol2qm74 8990 5 unreliable unreliable JJ cord-015021-pol2qm74 8990 6 in in IN cord-015021-pol2qm74 8990 7 pneumonia pneumonia NN cord-015021-pol2qm74 8990 8 , , , cord-015021-pol2qm74 8990 9 because because IN cord-015021-pol2qm74 8990 10 of of IN cord-015021-pol2qm74 8990 11 contamination contamination NN cord-015021-pol2qm74 8990 12 by by IN cord-015021-pol2qm74 8990 13 oropharyngeal oropharyngeal JJ cord-015021-pol2qm74 8990 14 flora flora NNS cord-015021-pol2qm74 8990 15 . . . cord-015021-pol2qm74 8991 1 Although although IN cord-015021-pol2qm74 8991 2 blood blood NN cord-015021-pol2qm74 8991 3 cultures culture NNS cord-015021-pol2qm74 8991 4 may may MD cord-015021-pol2qm74 8991 5 be be VB cord-015021-pol2qm74 8991 6 negative negative JJ cord-015021-pol2qm74 8991 7 , , , cord-015021-pol2qm74 8991 8 they -PRON- PRP cord-015021-pol2qm74 8991 9 provide provide VBP cord-015021-pol2qm74 8991 10 a a DT cord-015021-pol2qm74 8991 11 precise precise JJ cord-015021-pol2qm74 8991 12 diagnosis diagnosis NN cord-015021-pol2qm74 8991 13 and and CC cord-015021-pol2qm74 8991 14 should should MD cord-015021-pol2qm74 8991 15 be be VB cord-015021-pol2qm74 8991 16 obtained obtain VBN cord-015021-pol2qm74 8991 17 in in IN cord-015021-pol2qm74 8991 18 all all DT cord-015021-pol2qm74 8991 19 pneumonias pneumonia NNS cord-015021-pol2qm74 8991 20 . . . cord-015021-pol2qm74 8992 1 Other other JJ cord-015021-pol2qm74 8992 2 more more JJR cord-015021-pol2qm74 8992 3 invasive invasive JJ cord-015021-pol2qm74 8992 4 procedures procedure NNS cord-015021-pol2qm74 8992 5 are be VBP cord-015021-pol2qm74 8992 6 transtracheal transtracheal NN cord-015021-pol2qm74 8992 7 needle needle NN cord-015021-pol2qm74 8992 8 aspiration aspiration NN cord-015021-pol2qm74 8992 9 , , , cord-015021-pol2qm74 8992 10 fibrobronchoscopic fibrobronchoscopic JJ cord-015021-pol2qm74 8992 11 techniques technique NNS cord-015021-pol2qm74 8992 12 including include VBG cord-015021-pol2qm74 8992 13 protected protect VBN cord-015021-pol2qm74 8992 14 specimen specimen JJ cord-015021-pol2qm74 8992 15 brush brush NN cord-015021-pol2qm74 8992 16 and and CC cord-015021-pol2qm74 8992 17 bronchoalveolar bronchoalveolar NNP cord-015021-pol2qm74 8992 18 lavage lavage NN cord-015021-pol2qm74 8992 19 with with IN cord-015021-pol2qm74 8992 20 quantitative quantitative JJ cord-015021-pol2qm74 8992 21 culturing culturing NN cord-015021-pol2qm74 8992 22 and and CC cord-015021-pol2qm74 8992 23 cytological cytological JJ cord-015021-pol2qm74 8992 24 analysis analysis NN cord-015021-pol2qm74 8992 25 , , , cord-015021-pol2qm74 8992 26 transthoracic transthoracic NNP cord-015021-pol2qm74 8992 27 needle needle NN cord-015021-pol2qm74 8992 28 aspiration aspiration NN cord-015021-pol2qm74 8992 29 , , , cord-015021-pol2qm74 8992 30 thoracoscopy thoracoscopy NNP cord-015021-pol2qm74 8992 31 -guided -guided JJ cord-015021-pol2qm74 8992 32 biopsy biopsy NN cord-015021-pol2qm74 8992 33 and and CC cord-015021-pol2qm74 8992 34 open open JJ cord-015021-pol2qm74 8992 35 lung lung NN cord-015021-pol2qm74 8992 36 biopsy biopsy NN cord-015021-pol2qm74 8992 37 . . . cord-015021-pol2qm74 8993 1 Recently recently RB cord-015021-pol2qm74 8993 2 M. M. NNP cord-015021-pol2qm74 8993 3 E1-Ebiary E1-Ebiary NNP cord-015021-pol2qm74 8993 4 , , , cord-015021-pol2qm74 8993 5 A. A. NNP cord-015021-pol2qm74 8993 6 Torres Torres NNP cord-015021-pol2qm74 8993 7 et et NNP cord-015021-pol2qm74 8993 8 al al NNP cord-015021-pol2qm74 8993 9 , , , cord-015021-pol2qm74 8993 10 1993 1993 CD cord-015021-pol2qm74 8993 11 reported report VBD cord-015021-pol2qm74 8993 12 quantitative quantitative JJ cord-015021-pol2qm74 8993 13 cultures culture NNS cord-015021-pol2qm74 8993 14 of of IN cord-015021-pol2qm74 8993 15 endotracheal endotracheal NN cord-015021-pol2qm74 8993 16 aspirates aspirate NNS cord-015021-pol2qm74 8993 17 for for IN cord-015021-pol2qm74 8993 18 the the DT cord-015021-pol2qm74 8993 19 diagnosis diagnosis NN cord-015021-pol2qm74 8993 20 of of IN cord-015021-pol2qm74 8993 21 ventilator ventilator NN cord-015021-pol2qm74 8993 22 - - HYPH cord-015021-pol2qm74 8993 23 associated associate VBN cord-015021-pol2qm74 8993 24 pneumonia pneumonia NN cord-015021-pol2qm74 8993 25 offering offer VBG cord-015021-pol2qm74 8993 26 reliable reliable JJ cord-015021-pol2qm74 8993 27 results result NNS cord-015021-pol2qm74 8993 28 in in IN cord-015021-pol2qm74 8993 29 these these DT cord-015021-pol2qm74 8993 30 patients patient NNS cord-015021-pol2qm74 8993 31 and and CC cord-015021-pol2qm74 8993 32 should should MD cord-015021-pol2qm74 8993 33 be be VB cord-015021-pol2qm74 8993 34 further further RB cord-015021-pol2qm74 8993 35 investigated investigate VBN cord-015021-pol2qm74 8993 36 . . . cord-015021-pol2qm74 8994 1 Any any DT cord-015021-pol2qm74 8994 2 invasive invasive JJ cord-015021-pol2qm74 8994 3 procedure procedure NN cord-015021-pol2qm74 8994 4 in in IN cord-015021-pol2qm74 8994 5 a a DT cord-015021-pol2qm74 8994 6 severely severely RB cord-015021-pol2qm74 8994 7 ill ill JJ cord-015021-pol2qm74 8994 8 patient patient NN cord-015021-pol2qm74 8994 9 should should MD cord-015021-pol2qm74 8994 10 be be VB cord-015021-pol2qm74 8994 11 carefully carefully RB cord-015021-pol2qm74 8994 12 directed direct VBN cord-015021-pol2qm74 8994 13 weighing weigh VBG cord-015021-pol2qm74 8994 14 the the DT cord-015021-pol2qm74 8994 15 risks risk NNS cord-015021-pol2qm74 8994 16 as as RB cord-015021-pol2qm74 8994 17 well well RB cord-015021-pol2qm74 8994 18 as as IN cord-015021-pol2qm74 8994 19 the the DT cord-015021-pol2qm74 8994 20 benefits benefit NNS cord-015021-pol2qm74 8994 21 , , , cord-015021-pol2qm74 8994 22 whilst whilst IN cord-015021-pol2qm74 8994 23 taking take VBG cord-015021-pol2qm74 8994 24 the the DT cord-015021-pol2qm74 8994 25 underlying underlie VBG cord-015021-pol2qm74 8994 26 diseases disease NNS cord-015021-pol2qm74 8994 27 and and CC cord-015021-pol2qm74 8994 28 expected expect VBN cord-015021-pol2qm74 8994 29 survival survival NN cord-015021-pol2qm74 8994 30 into into IN cord-015021-pol2qm74 8994 31 consideration consideration NN cord-015021-pol2qm74 8994 32 . . . cord-015021-pol2qm74 8995 1 -Current -Current : cord-015021-pol2qm74 8995 2 therapeutic therapeutic JJ cord-015021-pol2qm74 8995 3 approach approach NN cord-015021-pol2qm74 8995 4 is be VBZ cord-015021-pol2qm74 8995 5 based base VBN cord-015021-pol2qm74 8995 6 mainly mainly RB cord-015021-pol2qm74 8995 7 on on IN cord-015021-pol2qm74 8995 8 monotherapy monotherapy NN cord-015021-pol2qm74 8995 9 with with IN cord-015021-pol2qm74 8995 10 broad broad JJ cord-015021-pol2qm74 8995 11 spectrum spectrum NN cord-015021-pol2qm74 8995 12 antibiotics antibiotic NNS cord-015021-pol2qm74 8995 13 . . . cord-015021-pol2qm74 8996 1 Combination combination NN cord-015021-pol2qm74 8996 2 therapy therapy NN cord-015021-pol2qm74 8996 3 is be VBZ cord-015021-pol2qm74 8996 4 apparently apparently RB cord-015021-pol2qm74 8996 5 indicated indicate VBN cord-015021-pol2qm74 8996 6 only only RB cord-015021-pol2qm74 8996 7 in in IN cord-015021-pol2qm74 8996 8 P. P. NNP cord-015021-pol2qm74 8996 9 aeruginosa aeruginosa NN cord-015021-pol2qm74 8996 10 infections infection NNS cord-015021-pol2qm74 8996 11 and and CC cord-015021-pol2qm74 8996 12 severe severe JJ cord-015021-pol2qm74 8996 13 S. S. NNP cord-015021-pol2qm74 8996 14 aureus aureus NN cord-015021-pol2qm74 8996 15 pneumonia pneumonia NN cord-015021-pol2qm74 8996 16 . . . cord-015021-pol2qm74 8996 17 _SP cord-015021-pol2qm74 8997 1 Graft graft NN cord-015021-pol2qm74 8997 2 infection infection NN cord-015021-pol2qm74 8997 3 can can MD cord-015021-pol2qm74 8997 4 lead lead VB cord-015021-pol2qm74 8997 5 to to IN cord-015021-pol2qm74 8997 6 fulminant fulminant JJ cord-015021-pol2qm74 8997 7 graft graft NN cord-015021-pol2qm74 8997 8 failure failure NN cord-015021-pol2qm74 8997 9 or or CC cord-015021-pol2qm74 8997 10 rapid rapid JJ cord-015021-pol2qm74 8997 11 progressive progressive JJ cord-015021-pol2qm74 8997 12 cirrhosis cirrhosis NN cord-015021-pol2qm74 8997 13 . . . cord-015021-pol2qm74 8998 1 For for IN cord-015021-pol2qm74 8998 2 prevention prevention NN cord-015021-pol2qm74 8998 3 of of IN cord-015021-pol2qm74 8998 4 graft graft NN cord-015021-pol2qm74 8998 5 infection infection NN cord-015021-pol2qm74 8998 6 immunoprophylaxis immunoprophylaxis NNP cord-015021-pol2qm74 8998 7 , , , cord-015021-pol2qm74 8998 8 i i PRP cord-015021-pol2qm74 8998 9 , , , cord-015021-pol2qm74 8998 10 e e NNP cord-015021-pol2qm74 8998 11 . . NNP cord-015021-pol2qm74 8998 12 administration administration NNP cord-015021-pol2qm74 8998 13 of of IN cord-015021-pol2qm74 8998 14 human human NNP cord-015021-pol2qm74 8998 15 polyclonal polyclonal NNP cord-015021-pol2qm74 8998 16 anti anti NNP cord-015021-pol2qm74 8998 17 HBs HBs NNP cord-015021-pol2qm74 8998 18 hypedmmunoglobuTin hypedmmunoglobuTin NNP cord-015021-pol2qm74 8998 19 ( ( -LRB- cord-015021-pol2qm74 8998 20 HIG HIG NNP cord-015021-pol2qm74 8998 21 ) ) -RRB- cord-015021-pol2qm74 8998 22 , , , cord-015021-pol2qm74 8998 23 starting start VBG cord-015021-pol2qm74 8998 24 in in IN cord-015021-pol2qm74 8998 25 the the DT cord-015021-pol2qm74 8998 26 anhepatic anhepatic JJ cord-015021-pol2qm74 8998 27 phase phase NN cord-015021-pol2qm74 8998 28 during during IN cord-015021-pol2qm74 8998 29 operation operation NN cord-015021-pol2qm74 8998 30 , , , cord-015021-pol2qm74 8998 31 has have VBZ cord-015021-pol2qm74 8998 32 proved prove VBN cord-015021-pol2qm74 8998 33 to to TO cord-015021-pol2qm74 8998 34 be be VB cord-015021-pol2qm74 8998 35 at at IN cord-015021-pol2qm74 8998 36 least least JJS cord-015021-pol2qm74 8998 37 partially partially RB cord-015021-pol2qm74 8998 38 succesful succesful JJ cord-015021-pol2qm74 8998 39 when when WRB cord-015021-pol2qm74 8998 40 performed perform VBN cord-015021-pol2qm74 8998 41 on on IN cord-015021-pol2qm74 8998 42 a a DT cord-015021-pol2qm74 8998 43 long long JJ cord-015021-pol2qm74 8998 44 term term NN cord-015021-pol2qm74 8998 45 basis basis NN cord-015021-pol2qm74 8998 46 . . . cord-015021-pol2qm74 8999 1 From from IN cord-015021-pol2qm74 8999 2 a a DT cord-015021-pol2qm74 8999 3 total total NN cord-015021-pol2qm74 8999 4 of of IN cord-015021-pol2qm74 8999 5 415 415 CD cord-015021-pol2qm74 8999 6 OLT OLT NNP cord-015021-pol2qm74 8999 7 in in IN cord-015021-pol2qm74 8999 8 adult adult NN cord-015021-pol2qm74 8999 9 patients patient NNS cord-015021-pol2qm74 8999 10 100 100 CD cord-015021-pol2qm74 8999 11 OLT OLT NNP cord-015021-pol2qm74 8999 12 were be VBD cord-015021-pol2qm74 8999 13 performed perform VBN cord-015021-pol2qm74 8999 14 for for IN cord-015021-pol2qm74 8999 15 HBsAg hbsag ADD cord-015021-pol2qm74 8999 16 positive positive JJ cord-015021-pol2qm74 8999 17 liver liver NN cord-015021-pol2qm74 8999 18 disease disease NN cord-015021-pol2qm74 8999 19 ( ( -LRB- cord-015021-pol2qm74 8999 20 cirrhosis cirrhosis NN cord-015021-pol2qm74 8999 21 n=86 n=86 VBN cord-015021-pol2qm74 8999 22 , , , cord-015021-pol2qm74 8999 23 fulminant fulminant JJ cord-015021-pol2qm74 8999 24 liver liver NN cord-015021-pol2qm74 8999 25 failure failure NN cord-015021-pol2qm74 8999 26 n=8 n=8 NN cord-015021-pol2qm74 8999 27 , , , cord-015021-pol2qm74 8999 28 retransplantation retransplantation NNP cord-015021-pol2qm74 8999 29 n=6 n=6 NNP cord-015021-pol2qm74 8999 30 ) ) -RRB- cord-015021-pol2qm74 8999 31 in in IN cord-015021-pol2qm74 8999 32 94 94 CD cord-015021-pol2qm74 8999 33 pat pat NNS cord-015021-pol2qm74 8999 34 . . . cord-015021-pol2qm74 9000 1 All all DT cord-015021-pol2qm74 9000 2 pat pat VBP cord-015021-pol2qm74 9000 3 . . . cord-015021-pol2qm74 9001 1 received receive VBD cord-015021-pol2qm74 9001 2 10.000 10.000 CD cord-015021-pol2qm74 9001 3 U U NNP cord-015021-pol2qm74 9001 4 HIG HIG NNP cord-015021-pol2qm74 9001 5 in in IN cord-015021-pol2qm74 9001 6 the the DT cord-015021-pol2qm74 9001 7 anhepatic anhepatic JJ cord-015021-pol2qm74 9001 8 phase phase NN cord-015021-pol2qm74 9001 9 and and CC cord-015021-pol2qm74 9001 10 2.000 2.000 CD cord-015021-pol2qm74 9001 11 U u NN cord-015021-pol2qm74 9001 12 / / SYM cord-015021-pol2qm74 9001 13 per per IN cord-015021-pol2qm74 9001 14 day day NN cord-015021-pol2qm74 9001 15 for for IN cord-015021-pol2qm74 9001 16 the the DT cord-015021-pol2qm74 9001 17 first first JJ cord-015021-pol2qm74 9001 18 week week NN cord-015021-pol2qm74 9001 19 . . . cord-015021-pol2qm74 9002 1 A a DT cord-015021-pol2qm74 9002 2 small small JJ cord-015021-pol2qm74 9002 3 group group NN cord-015021-pol2qm74 9002 4 of of IN cord-015021-pol2qm74 9002 5 9 9 CD cord-015021-pol2qm74 9002 6 pat pat NN cord-015021-pol2qm74 9002 7 . . . cord-015021-pol2qm74 9003 1 received receive VBD cord-015021-pol2qm74 9003 2 HIG HIG NNP cord-015021-pol2qm74 9003 3 only only RB cord-015021-pol2qm74 9003 4 for for IN cord-015021-pol2qm74 9003 5 I -PRON- PRP cord-015021-pol2qm74 9003 6 week week NN cord-015021-pol2qm74 9003 7 ( ( -LRB- cord-015021-pol2qm74 9003 8 short short JJ cord-015021-pol2qm74 9003 9 term term NN cord-015021-pol2qm74 9003 10 immunoprophylaxis immunoprophylaxis NNP cord-015021-pol2qm74 9003 11 ) ) -RRB- cord-015021-pol2qm74 9003 12 , , , cord-015021-pol2qm74 9003 13 in in IN cord-015021-pol2qm74 9003 14 all all DT cord-015021-pol2qm74 9003 15 other other JJ cord-015021-pol2qm74 9003 16 pat pat NNP cord-015021-pol2qm74 9003 17 . . . cord-015021-pol2qm74 9004 1 HIG HIG NNP cord-015021-pol2qm74 9004 2 is be VBZ cord-015021-pol2qm74 9004 3 administered administer VBN cord-015021-pol2qm74 9004 4 on on IN cord-015021-pol2qm74 9004 5 a a DT cord-015021-pol2qm74 9004 6 long long JJ cord-015021-pol2qm74 9004 7 term term NN cord-015021-pol2qm74 9004 8 basis basis NN cord-015021-pol2qm74 9004 9 to to TO cord-015021-pol2qm74 9004 10 keep keep VB cord-015021-pol2qm74 9004 11 anti anti JJ cord-015021-pol2qm74 9004 12 HBs hbs NN cord-015021-pol2qm74 9004 13 serum serum NN cord-015021-pol2qm74 9004 14 levels level NNS cord-015021-pol2qm74 9004 15 above above IN cord-015021-pol2qm74 9004 16 100 100 CD cord-015021-pol2qm74 9004 17 UII UII NNP cord-015021-pol2qm74 9004 18 or or CC cord-015021-pol2qm74 9004 19 until until IN cord-015021-pol2qm74 9004 20 graft graft NN cord-015021-pol2qm74 9004 21 infection infection NN cord-015021-pol2qm74 9004 22 occurs occur VBZ cord-015021-pol2qm74 9004 23 ( ( -LRB- cord-015021-pol2qm74 9004 24 long long JJ cord-015021-pol2qm74 9004 25 term term NN cord-015021-pol2qm74 9004 26 immunoprophylaxis);One immunoprophylaxis);one CD cord-015021-pol2qm74 9004 27 - - HYPH cord-015021-pol2qm74 9004 28 year year NN cord-015021-pol2qm74 9004 29 survival survival NN cord-015021-pol2qm74 9004 30 rates rate NNS cord-015021-pol2qm74 9004 31 are be VBP cord-015021-pol2qm74 9004 32 100 100 CD cord-015021-pol2qm74 9004 33 % % NN cord-015021-pol2qm74 9004 34 in in IN cord-015021-pol2qm74 9004 35 pat pat NNP cord-015021-pol2qm74 9004 36 . . . cord-015021-pol2qm74 9005 1 who who WP cord-015021-pol2qm74 9005 2 were be VBD cord-015021-pol2qm74 9005 3 transplanted transplant VBN cord-015021-pol2qm74 9005 4 for for IN cord-015021-pol2qm74 9005 5 fulminant fulminant JJ cord-015021-pol2qm74 9005 6 hepatitis hepatitis NN cord-015021-pol2qm74 9005 7 , , , cord-015021-pol2qm74 9005 8 96 96 CD cord-015021-pol2qm74 9005 9 % % NN cord-015021-pol2qm74 9005 10 in in IN cord-015021-pol2qm74 9005 11 pat pat NNP cord-015021-pol2qm74 9005 12 . . . cord-015021-pol2qm74 9006 1 with with IN cord-015021-pol2qm74 9006 2 cirrhosis cirrhosis NN cord-015021-pol2qm74 9006 3 and and CC cord-015021-pol2qm74 9006 4 long long JJ cord-015021-pol2qm74 9006 5 term term NN cord-015021-pol2qm74 9006 6 prophylaxis prophylaxis NN cord-015021-pol2qm74 9006 7 , , , cord-015021-pol2qm74 9006 8 and and CC cord-015021-pol2qm74 9006 9 78 78 CD cord-015021-pol2qm74 9006 10 % % NN cord-015021-pol2qm74 9006 11 ir~ ir~ NN cord-015021-pol2qm74 9006 12 pat pat NNP cord-015021-pol2qm74 9006 13 . . . cord-015021-pol2qm74 9007 1 with with IN cord-015021-pol2qm74 9007 2 short short JJ cord-015021-pol2qm74 9007 3 term term NN cord-015021-pol2qm74 9007 4 prophylaxis prophylaxis NN cord-015021-pol2qm74 9007 5 . . . cord-015021-pol2qm74 9008 1 All all DT cord-015021-pol2qm74 9008 2 fatalities fatality NNS cord-015021-pol2qm74 9008 3 were be VBD cord-015021-pol2qm74 9008 4 related relate VBN cord-015021-pol2qm74 9008 5 to to IN cord-015021-pol2qm74 9008 6 HBV HBV NNP cord-015021-pol2qm74 9008 7 graft graft NN cord-015021-pol2qm74 9008 8 infection infection NN cord-015021-pol2qm74 9008 9 . . . cord-015021-pol2qm74 9009 1 The the DT cord-015021-pol2qm74 9009 2 total total JJ cord-015021-pol2qm74 9009 3 rate rate NN cord-015021-pol2qm74 9009 4 of of IN cord-015021-pol2qm74 9009 5 graft graft NN cord-015021-pol2qm74 9009 6 infection infection NN cord-015021-pol2qm74 9009 7 was be VBD cord-015021-pol2qm74 9009 8 100 100 CD cord-015021-pol2qm74 9009 9 % % NN cord-015021-pol2qm74 9009 10 under under IN cord-015021-pol2qm74 9009 11 short short JJ cord-015021-pol2qm74 9009 12 term term NN cord-015021-pol2qm74 9009 13 prophylaxis prophylaxis NN cord-015021-pol2qm74 9009 14 and and CC cord-015021-pol2qm74 9009 15 was be VBD cord-015021-pol2qm74 9009 16 independent independent JJ cord-015021-pol2qm74 9009 17 from from IN cord-015021-pol2qm74 9009 18 preoperative preoperative JJ cord-015021-pol2qm74 9009 19 HBV HBV NNP cord-015021-pol2qm74 9009 20 DNA dna NN cord-015021-pol2qm74 9009 21 status status NN cord-015021-pol2qm74 9009 22 , , , cord-015021-pol2qm74 9009 23 Under under IN cord-015021-pol2qm74 9009 24 long long JJ cord-015021-pol2qm74 9009 25 term term NN cord-015021-pol2qm74 9009 26 prophylaxis prophylaxis NN cord-015021-pol2qm74 9009 27 graft graft NN cord-015021-pol2qm74 9009 28 infection infection NN cord-015021-pol2qm74 9009 29 occurad occurad NN cord-015021-pol2qm74 9009 30 in in IN cord-015021-pol2qm74 9009 31 28 28 CD cord-015021-pol2qm74 9009 32 % % NN cord-015021-pol2qm74 9009 33 in in IN cord-015021-pol2qm74 9009 34 pat pat NNP cord-015021-pol2qm74 9009 35 , , , cord-015021-pol2qm74 9009 36 negative negative JJ cord-015021-pol2qm74 9009 37 for for IN cord-015021-pol2qm74 9009 38 HBV HBV NNP cord-015021-pol2qm74 9009 39 DNA DNA NNP cord-015021-pol2qm74 9009 40 . . . cord-015021-pol2qm74 9010 1 In in IN cord-015021-pol2qm74 9010 2 HBV HBV NNP cord-015021-pol2qm74 9010 3 DNA DNA NNP cord-015021-pol2qm74 9010 4 positive positive JJ cord-015021-pol2qm74 9010 5 pat pat NN cord-015021-pol2qm74 9010 6 . . . cord-015021-pol2qm74 9010 7 infection infection NN cord-015021-pol2qm74 9010 8 rate rate NN cord-015021-pol2qm74 9010 9 was be VBD cord-015021-pol2qm74 9010 10 56 56 CD cord-015021-pol2qm74 9010 11 % % NN cord-015021-pol2qm74 9010 12 , , , cord-015021-pol2qm74 9010 13 the the DT cord-015021-pol2qm74 9010 14 total total JJ cord-015021-pol2qm74 9010 15 rate rate NN cord-015021-pol2qm74 9010 16 of of IN cord-015021-pol2qm74 9010 17 reinfection reinfection NN cord-015021-pol2qm74 9010 18 for for IN cord-015021-pol2qm74 9010 19 all all DT cord-015021-pol2qm74 9010 20 pat pat NN cord-015021-pol2qm74 9010 21 . . . cord-015021-pol2qm74 9011 1 with with IN cord-015021-pol2qm74 9011 2 long long JJ cord-015021-pol2qm74 9011 3 term term NN cord-015021-pol2qm74 9011 4 prophylaxis prophylaxis NN cord-015021-pol2qm74 9011 5 was be VBD cord-015021-pol2qm74 9011 6 36%The 36%the CD cord-015021-pol2qm74 9011 7 results result NNS cord-015021-pol2qm74 9011 8 of of IN cord-015021-pol2qm74 9011 9 liver liver NN cord-015021-pol2qm74 9011 10 transplantation transplantation NN cord-015021-pol2qm74 9011 11 in in IN cord-015021-pol2qm74 9011 12 HBsAg HBsAg NNP cord-015021-pol2qm74 9011 13 positive positive JJ cord-015021-pol2qm74 9011 14 pat pat NN cord-015021-pol2qm74 9011 15 . . . cord-015021-pol2qm74 9012 1 are be VBP cord-015021-pol2qm74 9012 2 comparable comparable JJ cord-015021-pol2qm74 9012 3 to to IN cord-015021-pol2qm74 9012 4 other other JJ cord-015021-pol2qm74 9012 5 indications indication NNS cord-015021-pol2qm74 9012 6 , , , cord-015021-pol2qm74 9012 7 Graft graft NN cord-015021-pol2qm74 9012 8 infection infection NN cord-015021-pol2qm74 9012 9 with with IN cord-015021-pol2qm74 9012 10 hepatitis hepatitis NN cord-015021-pol2qm74 9012 11 B B NNP cord-015021-pol2qm74 9012 12 virus virus NN cord-015021-pol2qm74 9012 13 ist ist NNP cord-015021-pol2qm74 9012 14 the the DT cord-015021-pol2qm74 9012 15 major major JJ cord-015021-pol2qm74 9012 16 risk risk NN cord-015021-pol2qm74 9012 17 factor factor NN cord-015021-pol2qm74 9012 18 for for IN cord-015021-pol2qm74 9012 19 these these DT cord-015021-pol2qm74 9012 20 patients patient NNS cord-015021-pol2qm74 9012 21 . . . cord-015021-pol2qm74 9013 1 Under under IN cord-015021-pol2qm74 9013 2 long long JJ cord-015021-pol2qm74 9013 3 term term NN cord-015021-pol2qm74 9013 4 therapy therapy NN cord-015021-pol2qm74 9013 5 with with IN cord-015021-pol2qm74 9013 6 HIG HIG NNP cord-015021-pol2qm74 9013 7 the the DT cord-015021-pol2qm74 9013 8 rate rate NN cord-015021-pol2qm74 9013 9 of of IN cord-015021-pol2qm74 9013 10 graft graft NN cord-015021-pol2qm74 9013 11 infection infection NN cord-015021-pol2qm74 9013 12 can can MD cord-015021-pol2qm74 9013 13 be be VB cord-015021-pol2qm74 9013 14 significantly significantly RB cord-015021-pol2qm74 9013 15 reduced reduce VBN cord-015021-pol2qm74 9013 16 . . . cord-015021-pol2qm74 9014 1 THE the DT cord-015021-pol2qm74 9014 2 CRUCIAL CRUCIAL NNP cord-015021-pol2qm74 9014 3 CELLULAR cellular NN cord-015021-pol2qm74 9014 4 ELEMENT element NN cord-015021-pol2qm74 9014 5 FOR for IN cord-015021-pol2qm74 9014 6 MODS MODS NNP cord-015021-pol2qm74 9014 7 - - HYPH cord-015021-pol2qm74 9014 8 MOF MOF NNP cord-015021-pol2qm74 9014 9 : : : cord-015021-pol2qm74 9015 1 MONOCYI'F_./M MONOCYI'F_./M NNP cord-015021-pol2qm74 9015 2 ACROPHAOE ACROPHAOE NNP cord-015021-pol2qm74 9015 3 Ronald Ronald NNP cord-015021-pol2qm74 9015 4 V. V. NNP cord-015021-pol2qm74 9015 5 Meier Meier NNP cord-015021-pol2qm74 9015 6 , , , cord-015021-pol2qm74 9015 7 M M NNP cord-015021-pol2qm74 9015 8 , , , cord-015021-pol2qm74 9015 9 D. D. NNP cord-015021-pol2qm74 9015 10 , , , cord-015021-pol2qm74 9015 11 F.A F.A NNP cord-015021-pol2qm74 9015 12 , , , cord-015021-pol2qm74 9015 13 C C NNP cord-015021-pol2qm74 9015 14 , , , cord-015021-pol2qm74 9015 15 S. S. NNP cord-015021-pol2qm74 9016 1 The the DT cord-015021-pol2qm74 9016 2 severely severely RB cord-015021-pol2qm74 9016 3 : : : cord-015021-pol2qm74 9016 4 injured injure VBN cord-015021-pol2qm74 9016 5 or or CC cord-015021-pol2qm74 9016 6 crldcally crldcally RB cord-015021-pol2qm74 9016 7 ill ill JJ cord-015021-pol2qm74 9016 8 surgical surgical JJ cord-015021-pol2qm74 9016 9 patient patient NN cord-015021-pol2qm74 9016 10 is be VBZ cord-015021-pol2qm74 9016 11 at at IN cord-015021-pol2qm74 9016 12 high high JJ cord-015021-pol2qm74 9016 13 risk risk NN cord-015021-pol2qm74 9016 14 for for IN cord-015021-pol2qm74 9016 15 immune immune JJ cord-015021-pol2qm74 9016 16 dysfunction dysfunction NN cord-015021-pol2qm74 9016 17 . . . cord-015021-pol2qm74 9017 1 A a DT cord-015021-pol2qm74 9017 2 major major JJ cord-015021-pol2qm74 9017 3 consequence consequence NN cord-015021-pol2qm74 9017 4 of of IN cord-015021-pol2qm74 9017 5 this this DT cord-015021-pol2qm74 9017 6 immune immune JJ cord-015021-pol2qm74 9017 7 dysfunction dysfunction NN cord-015021-pol2qm74 9017 8 is be VBZ cord-015021-pol2qm74 9017 9 multiple multiple JJ cord-015021-pol2qm74 9017 10 organ organ NN cord-015021-pol2qm74 9017 11 dysfunction dysfunction NN cord-015021-pol2qm74 9017 12 and and CC cord-015021-pol2qm74 9017 13 failure failure NN cord-015021-pol2qm74 9017 14 leading lead VBG cord-015021-pol2qm74 9017 15 to to IN cord-015021-pol2qm74 9017 16 death death NN cord-015021-pol2qm74 9017 17 , , , cord-015021-pol2qm74 9017 18 The the DT cord-015021-pol2qm74 9017 19 underlying underlying JJ cord-015021-pol2qm74 9017 20 etiology etiology NN cord-015021-pol2qm74 9017 21 is be VBZ cord-015021-pol2qm74 9017 22 now now RB cord-015021-pol2qm74 9017 23 recognized recognize VBN cord-015021-pol2qm74 9017 24 to to TO cord-015021-pol2qm74 9017 25 be be VB cord-015021-pol2qm74 9017 26 an an DT cord-015021-pol2qm74 9017 27 uncontrolled uncontrolled JJ cord-015021-pol2qm74 9017 28 , , , cord-015021-pol2qm74 9017 29 unfocused unfocused JJ cord-015021-pol2qm74 9017 30 , , , cord-015021-pol2qm74 9017 31 disseminated disseminate VBN cord-015021-pol2qm74 9017 32 activation activation NN cord-015021-pol2qm74 9017 33 of of IN cord-015021-pol2qm74 9017 34 the the DT cord-015021-pol2qm74 9017 35 host host NN cord-015021-pol2qm74 9017 36 normally normally RB cord-015021-pol2qm74 9017 37 protective protective VBP cord-015021-pol2qm74 9017 38 inflammatory inflammatory NN cord-015021-pol2qm74 9017 39 . . . cord-015021-pol2qm74 9018 1 , , , cord-015021-pol2qm74 9018 2 , , , cord-015021-pol2qm74 9018 3 cascades cascade NNS cord-015021-pol2qm74 9018 4 .. .. . cord-015021-pol2qm74 9019 1 The the DT cord-015021-pol2qm74 9019 2 resultant resultant JJ cord-015021-pol2qm74 9019 3 " " `` cord-015021-pol2qm74 9019 4 mahgnant mahgnant JJ cord-015021-pol2qm74 9019 5 ' ' '' cord-015021-pol2qm74 9019 6 systemic systemic JJ cord-015021-pol2qm74 9019 7 " " '' cord-015021-pol2qm74 9019 8 inflan'a'natlon inflan'a'natlon NNP cord-015021-pol2qm74 9019 9 produces produce VBZ cord-015021-pol2qm74 9019 10 d d NNP cord-015021-pol2qm74 9019 11 ~ ~ NFP cord-015021-pol2qm74 9019 12 ffuso ffuso NNP cord-015021-pol2qm74 9019 13 multiple multiple JJ cord-015021-pol2qm74 9019 14 organ organ NN cord-015021-pol2qm74 9019 15 bystander bystander NN cord-015021-pol2qm74 9019 16 injury injury NN cord-015021-pol2qm74 9019 17 ! ! . cord-015021-pol2qm74 9020 1 eading eade VBG cord-015021-pol2qm74 9020 2 to to IN cord-015021-pol2qm74 9020 3 progressive progressive JJ cord-015021-pol2qm74 9020 4 organ organ NN cord-015021-pol2qm74 9020 5 dysfunction dysfunction NN cord-015021-pol2qm74 9020 6 and and CC cord-015021-pol2qm74 9020 7 failure failure NN cord-015021-pol2qm74 9020 8 . . . cord-015021-pol2qm74 9021 1 Systemic systemic JJ cord-015021-pol2qm74 9021 2 malignant malignant JJ cord-015021-pol2qm74 9021 3 inflammation inflammation NN cord-015021-pol2qm74 9021 4 involves involve VBZ cord-015021-pol2qm74 9021 5 diffuse diffuse JJ cord-015021-pol2qm74 9021 6 actlvatton actlvatton NNS cord-015021-pol2qm74 9021 7 of of IN cord-015021-pol2qm74 9021 8 all all DT cord-015021-pol2qm74 9021 9 components component NNS cord-015021-pol2qm74 9021 10 of of IN cord-015021-pol2qm74 9021 11 the the DT cord-015021-pol2qm74 9021 12 humoral humoral JJ cord-015021-pol2qm74 9021 13 and and CC cord-015021-pol2qm74 9021 14 cellular cellular JJ cord-015021-pol2qm74 9021 15 inflammatory inflammatory JJ cord-015021-pol2qm74 9021 16 host host NN cord-015021-pol2qm74 9021 17 response response NN cord-015021-pol2qm74 9021 18 . . . cord-015021-pol2qm74 9022 1 Of of IN cord-015021-pol2qm74 9022 2 these these DT cord-015021-pol2qm74 9022 3 various various JJ cord-015021-pol2qm74 9022 4 components component NNS cord-015021-pol2qm74 9022 5 , , , cord-015021-pol2qm74 9022 6 the the DT cord-015021-pol2qm74 9022 7 macropha macropha NN cord-015021-pol2qm74 9022 8 ~ ~ NFP cord-015021-pol2qm74 9022 9 e e NNP cord-015021-pol2qm74 9022 10 is be VBZ cord-015021-pol2qm74 9022 11 the the DT cord-015021-pol2qm74 9022 12 crucial crucial JJ cord-015021-pol2qm74 9022 13 central central JJ cord-015021-pol2qm74 9022 14 cellular cellular JJ cord-015021-pol2qm74 9022 15 element element NN cord-015021-pol2qm74 9022 16 . . . cord-015021-pol2qm74 9023 1 The the DT cord-015021-pol2qm74 9023 2 tissue tissue NN cord-015021-pol2qm74 9023 3 fixed fix VBN cord-015021-pol2qm74 9023 4 macrophage macrophage NN cord-015021-pol2qm74 9023 5 Is be VBZ cord-015021-pol2qm74 9023 6 ideally ideally RB cord-015021-pol2qm74 9023 7 located locate VBN cord-015021-pol2qm74 9023 8 diffusely diffusely RB cord-015021-pol2qm74 9023 9 throughout throughout IN cord-015021-pol2qm74 9023 10 the the DT cord-015021-pol2qm74 9023 11 various various JJ cord-015021-pol2qm74 9023 12 organs organ NNS cord-015021-pol2qm74 9023 13 injured injure VBN cord-015021-pol2qm74 9023 14 to to TO cord-015021-pol2qm74 9023 15 orchestrate orchestrate VB cord-015021-pol2qm74 9023 16 the the DT cord-015021-pol2qm74 9023 17 inflammatory inflammatory JJ cord-015021-pol2qm74 9023 18 process process NN cord-015021-pol2qm74 9023 19 . . . cord-015021-pol2qm74 9024 1 The the DT cord-015021-pol2qm74 9024 2 macrophage macrophage NN cord-015021-pol2qm74 9024 3 is be VBZ cord-015021-pol2qm74 9024 4 long long RB cord-015021-pol2qm74 9024 5 - - HYPH cord-015021-pol2qm74 9024 6 lived live VBN cord-015021-pol2qm74 9024 7 and and CC cord-015021-pol2qm74 9024 8 highly highly RB cord-015021-pol2qm74 9024 9 metabolic metabolic JJ cord-015021-pol2qm74 9024 10 , , , cord-015021-pol2qm74 9024 11 The the DT cord-015021-pol2qm74 9024 12 macrophage macrophage NN cord-015021-pol2qm74 9024 13 regulates regulate VBZ cord-015021-pol2qm74 9024 14 both both CC cord-015021-pol2qm74 9024 15 the the DT cord-015021-pol2qm74 9024 16 extent extent NN cord-015021-pol2qm74 9024 17 and and CC cord-015021-pol2qm74 9024 18 the the DT cord-015021-pol2qm74 9024 19 dissemination dissemination NN cord-015021-pol2qm74 9024 20 of of IN cord-015021-pol2qm74 9024 21 the the DT cord-015021-pol2qm74 9024 22 inflammatory inflammatory JJ cord-015021-pol2qm74 9024 23 processes process NNS cord-015021-pol2qm74 9024 24 . . . cord-015021-pol2qm74 9025 1 The the DT cord-015021-pol2qm74 9025 2 macrophage macrophage NN cord-015021-pol2qm74 9025 3 is be VBZ cord-015021-pol2qm74 9025 4 an an DT cord-015021-pol2qm74 9025 5 exu'emely exu'emely RB cord-015021-pol2qm74 9025 6 active active JJ cord-015021-pol2qm74 9025 7 c¢11 c¢11 NNP cord-015021-pol2qm74 9025 8 capable capable JJ cord-015021-pol2qm74 9025 9 of of IN cord-015021-pol2qm74 9025 10 producing produce VBG cord-015021-pol2qm74 9025 11 and and CC cord-015021-pol2qm74 9025 12 releasing release VBG cord-015021-pol2qm74 9025 13 not not RB cord-015021-pol2qm74 9025 14 only only RB cord-015021-pol2qm74 9025 15 directly directly RB cord-015021-pol2qm74 9025 16 eytotoxlc eytotoxlc JJ cord-015021-pol2qm74 9025 17 agents agent NNS cord-015021-pol2qm74 9025 18 , , , cord-015021-pol2qm74 9025 19 s s NNP cord-015021-pol2qm74 9025 20 irnil~ irnil~ NNP cord-015021-pol2qm74 9025 21 , , , cord-015021-pol2qm74 9025 22 to to IN cord-015021-pol2qm74 9025 23 the the DT cord-015021-pol2qm74 9025 24 neutrophil neutrophil NN cord-015021-pol2qm74 9025 25 , , , cord-015021-pol2qm74 9025 26 including include VBG cord-015021-pol2qm74 9025 27 oxidants oxidant NNS cord-015021-pol2qm74 9025 28 and and CC cord-015021-pol2qm74 9025 29 numerous numerous JJ cord-015021-pol2qm74 9025 30 proteases protease NNS cord-015021-pol2qm74 9025 31 out out RB cord-015021-pol2qm74 9025 32 also also RB cord-015021-pol2qm74 9025 33 the the DT cord-015021-pol2qm74 9025 34 multitude multitude NN cord-015021-pol2qm74 9025 35 of of IN cord-015021-pol2qm74 9025 36 other other JJ cord-015021-pol2qm74 9025 37 cytokines cytokine NNS cord-015021-pol2qm74 9025 38 and and CC cord-015021-pol2qm74 9025 39 initiators initiator NNS cord-015021-pol2qm74 9025 40 of of IN cord-015021-pol2qm74 9025 41 the the DT cord-015021-pol2qm74 9025 42 interacting interact VBG cord-015021-pol2qm74 9025 43 inflammatory inflammatory JJ cord-015021-pol2qm74 9025 44 cascades cascade NNS cord-015021-pol2qm74 9025 45 . . . cord-015021-pol2qm74 9026 1 The the DT cord-015021-pol2qm74 9026 2 macrophage macrophage NN cord-015021-pol2qm74 9026 3 is be VBZ cord-015021-pol2qm74 9026 4 the the DT cord-015021-pol2qm74 9026 5 central central JJ cord-015021-pol2qm74 9026 6 source source NN cord-015021-pol2qm74 9026 7 for for IN cord-015021-pol2qm74 9026 8 ehemotactic ehemotactic JJ cord-015021-pol2qm74 9026 9 agents agent NNS cord-015021-pol2qm74 9026 10 ( ( -LRB- cord-015021-pol2qm74 9026 11 IL-8 IL-8 NNP cord-015021-pol2qm74 9026 12 , , , cord-015021-pol2qm74 9026 13 LTB4 LTB4 NNP cord-015021-pol2qm74 9026 14 , , , cord-015021-pol2qm74 9026 15 C5a C5a NNP cord-015021-pol2qm74 9026 16 ) ) -RRB- cord-015021-pol2qm74 9026 17 for for IN cord-015021-pol2qm74 9026 18 neutrophils neutrophil NNS cord-015021-pol2qm74 9026 19 and and CC cord-015021-pol2qm74 9026 20 other other JJ cord-015021-pol2qm74 9026 21 inflammatory inflammatory JJ cord-015021-pol2qm74 9026 22 cells cell NNS cord-015021-pol2qm74 9026 23 , , , cord-015021-pol2qm74 9026 24 production production NN cord-015021-pol2qm74 9026 25 of of IN cord-015021-pol2qm74 9026 26 vasoaetive vasoaetive NNP cord-015021-pol2qm74 9026 27 arachidonie arachidonie NNP cord-015021-pol2qm74 9026 28 acid acid NN cord-015021-pol2qm74 9026 29 metabolites metabolite NNS cord-015021-pol2qm74 9026 30 ( ( -LRB- cord-015021-pol2qm74 9026 31 TX TX NNP cord-015021-pol2qm74 9026 32 , , , cord-015021-pol2qm74 9026 33 PGI2 PGI2 NNP cord-015021-pol2qm74 9026 34 , , , cord-015021-pol2qm74 9026 35 POE POE NNP cord-015021-pol2qm74 9026 36 , , , cord-015021-pol2qm74 9026 37 LT LT NNP cord-015021-pol2qm74 9026 38 's 's POS cord-015021-pol2qm74 9026 39 ) ) -RRB- cord-015021-pol2qm74 9026 40 , , , cord-015021-pol2qm74 9026 41 complement complement VB cord-015021-pol2qm74 9026 42 components component NNS cord-015021-pol2qm74 9026 43 ( ( -LRB- cord-015021-pol2qm74 9026 44 C3a C3a NNP cord-015021-pol2qm74 9026 45 , , , cord-015021-pol2qm74 9026 46 CSa CSa NNP cord-015021-pol2qm74 9026 47 ) ) -RRB- cord-015021-pol2qm74 9026 48 , , , cord-015021-pol2qm74 9026 49 thrombotic thrombotic JJ cord-015021-pol2qm74 9026 50 agents agent NNS cord-015021-pol2qm74 9026 51 ( ( -LRB- cord-015021-pol2qm74 9026 52 PCA PCA NNP cord-015021-pol2qm74 9026 53 , , , cord-015021-pol2qm74 9026 54 TX TX NNP cord-015021-pol2qm74 9026 55 ) ) -RRB- cord-015021-pol2qm74 9026 56 , , , cord-015021-pol2qm74 9026 57 metabolic metabolic JJ cord-015021-pol2qm74 9026 58 and and CC cord-015021-pol2qm74 9026 59 physiologic physiologic JJ cord-015021-pol2qm74 9026 60 modulators modulator NNS cord-015021-pol2qm74 9026 61 ( ( -LRB- cord-015021-pol2qm74 9026 62 IL,1 il,1 RB cord-015021-pol2qm74 9026 63 , , , cord-015021-pol2qm74 9026 64 IL-6 IL-6 NNP cord-015021-pol2qm74 9026 65 or or CC cord-015021-pol2qm74 9026 66 TNF TNF NNP cord-015021-pol2qm74 9026 67 ) ) -RRB- cord-015021-pol2qm74 9026 68 , , , cord-015021-pol2qm74 9026 69 and and CC cord-015021-pol2qm74 9026 70 immunosuppressivc immunosuppressivc NNP cord-015021-pol2qm74 9026 71 agents agent NNS cord-015021-pol2qm74 9026 72 ( ( -LRB- cord-015021-pol2qm74 9026 73 POE2 POE2 NNP cord-015021-pol2qm74 9026 74 , , , cord-015021-pol2qm74 9026 75 IL-10 IL-10 NNP cord-015021-pol2qm74 9026 76 ) ) -RRB- cord-015021-pol2qm74 9026 77 . . . cord-015021-pol2qm74 9027 1 These these DT cord-015021-pol2qm74 9027 2 products product NNS cord-015021-pol2qm74 9027 3 of of IN cord-015021-pol2qm74 9027 4 the the DT cord-015021-pol2qm74 9027 5 macrophage macrophage NN cord-015021-pol2qm74 9027 6 are be VBP cord-015021-pol2qm74 9027 7 highly highly RB cord-015021-pol2qm74 9027 8 effective effective JJ cord-015021-pol2qm74 9027 9 in in IN cord-015021-pol2qm74 9027 10 enhancing enhance VBG cord-015021-pol2qm74 9027 11 and and CC cord-015021-pol2qm74 9027 12 augmenting augment VBG cord-015021-pol2qm74 9027 13 the the DT cord-015021-pol2qm74 9027 14 inflammatory inflammatory JJ cord-015021-pol2qm74 9027 15 response response NN cord-015021-pol2qm74 9027 16 . . . cord-015021-pol2qm74 9028 1 Disseminated disseminate VBN cord-015021-pol2qm74 9028 2 activation activation NN cord-015021-pol2qm74 9028 3 otthe otthe DT cord-015021-pol2qm74 9028 4 macrophage macrophage NN cord-015021-pol2qm74 9028 5 Is be VBZ cord-015021-pol2qm74 9028 6 critical critical JJ cord-015021-pol2qm74 9028 7 to to IN cord-015021-pol2qm74 9028 8 the the DT cord-015021-pol2qm74 9028 9 induction induction NN cord-015021-pol2qm74 9028 10 of of IN cord-015021-pol2qm74 9028 11 the the DT cord-015021-pol2qm74 9028 12 long long JJ cord-015021-pol2qm74 9028 13 - - HYPH cord-015021-pol2qm74 9028 14 term term NN cord-015021-pol2qm74 9028 15 diffuse diffuse JJ cord-015021-pol2qm74 9028 16 activation activation NN cord-015021-pol2qm74 9028 17 of of IN cord-015021-pol2qm74 9028 18 inflammation inflammation NN cord-015021-pol2qm74 9028 19 necessary necessary JJ cord-015021-pol2qm74 9028 20 to to TO cord-015021-pol2qm74 9028 21 induce induce VB cord-015021-pol2qm74 9028 22 multiple multiple JJ cord-015021-pol2qm74 9028 23 organ organ NN cord-015021-pol2qm74 9028 24 injury injury NN cord-015021-pol2qm74 9028 25 and and CC cord-015021-pol2qm74 9028 26 failure failure NN cord-015021-pol2qm74 9028 27 . . . cord-015021-pol2qm74 9029 1 Our -PRON- PRP$ cord-015021-pol2qm74 9029 2 ability ability NN cord-015021-pol2qm74 9029 3 to to TO cord-015021-pol2qm74 9029 4 elucidate elucidate VB cord-015021-pol2qm74 9029 5 the the DT cord-015021-pol2qm74 9029 6 molecular molecular JJ cord-015021-pol2qm74 9029 7 mechanisms mechanism NNS cord-015021-pol2qm74 9029 8 that that WDT cord-015021-pol2qm74 9029 9 control control VBP cord-015021-pol2qm74 9029 10 the the DT cord-015021-pol2qm74 9029 11 macrophage macrophage NN cord-015021-pol2qm74 9029 12 will will MD cord-015021-pol2qm74 9029 13 lead lead VB cord-015021-pol2qm74 9029 14 to to IN cord-015021-pol2qm74 9029 15 our -PRON- PRP$ cord-015021-pol2qm74 9029 16 ability ability NN cord-015021-pol2qm74 9029 17 to to TO cord-015021-pol2qm74 9029 18 conu'ol conu'ol VB cord-015021-pol2qm74 9029 19 the the DT cord-015021-pol2qm74 9029 20 maerophage maerophage NN cord-015021-pol2qm74 9029 21 response response NN cord-015021-pol2qm74 9029 22 and and CC cord-015021-pol2qm74 9029 23 prevent prevent VB cord-015021-pol2qm74 9029 24 MODS MODS NNP cord-015021-pol2qm74 9029 25 - - HYPH cord-015021-pol2qm74 9029 26 MOF.Flarborview MOF.Flarborview NNP cord-015021-pol2qm74 9029 27 Medical Medical NNP cord-015021-pol2qm74 9029 28 Center Center NNP cord-015021-pol2qm74 9029 29 , , , cord-015021-pol2qm74 9029 30 325 325 CD cord-015021-pol2qm74 9029 31 - - HYPH cord-015021-pol2qm74 9029 32 9th 9th NN cord-015021-pol2qm74 9029 33 Ave Ave NNP cord-015021-pol2qm74 9029 34 ZA-16 ZA-16 NNP cord-015021-pol2qm74 9029 35 , , , cord-015021-pol2qm74 9029 36 Seattle Seattle NNP cord-015021-pol2qm74 9029 37 , , , cord-015021-pol2qm74 9029 38 WA WA NNP cord-015021-pol2qm74 9029 39 98104 98104 CD cord-015021-pol2qm74 9029 40 USA USA NNP