id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-280158-3fhhuzg5	Hoffman, Paul S.	Antibacterial Discovery: 21st Century Challenges	2020-04-28		.txt	text/plain	5288	248	39	The key questions dealt with in this review include: (1) If mutation based drug resistance is the major challenge to any new antibiotic, is it possible to find drug targets and new chemical entities that can escape this outcome; (2) Is the number of novel chemical classes of antibacterials limited by the number of broad spectrum drug targets; and (3) If true, then should we focus efforts on subgroups of pathogens like Gram negative or positive bacteria only, anaerobic bacteria or other group where the range of common essential genes is likely greater?. The pharmaceutical industry abandoned NP divisions long ago in favor of high throughput screens of compound libraries against novel drug targets (another failure, see below); or, more productively to create next generation derivatives of existing antibiotics, a strategy that has worked well and continues today as judged by the number of analogues in the current pipeline.	./cache/cord-280158-3fhhuzg5.txt	./txt/cord-280158-3fhhuzg5.txt