id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-310474-hip7t0jx	Hansford, Karl A.	Nontraditional Antibiotics—Challenges and Triumphs	2020-04-09		.txt	text/plain	943	49	34	Although the future potential of nontraditional therapies is viewed with cautious optimism, adequate resourcing will be critical to demonstrate clinical impact, especially when many of the translational criteria associated with direct-acting small molecule therapeutics will likely be incongruent with the nontraditional development pathway. The three review articles by Zurawski and McLendon [5] , Nikolich and Filippov [6] , and Ghose and Euler [7] give a superb timely survey of how monoclonal antibodies, bacteriophages and lysins, respectively, are currently being explored in the treatment of bacterial infections. Turning to small molecule therapeutics, Frei's perspective on the untapped potential of metal complexes as antibiotics provides a compelling view that chemical classes often misconstrued as only being useful for certain applications should not be overlooked as potential sources of new chemotypes to fight bacterial infections [8] . Critical Parameters for the Development of Novel Therapies for Severe and Resistant Infections-A Case Study on CAL02, a Non-Traditional Broad-Spectrum Anti-Virulence Drug	./cache/cord-310474-hip7t0jx.txt	./txt/cord-310474-hip7t0jx.txt