id sid tid token lemma pos cord-326673-p8qbxi57 1 1 key key JJ cord-326673-p8qbxi57 1 2 : : : cord-326673-p8qbxi57 1 3 cord-326673-p8qbxi57 cord-326673-p8qbxi57 ADD cord-326673-p8qbxi57 2 1 authors author NNS cord-326673-p8qbxi57 2 2 : : : cord-326673-p8qbxi57 2 3 Kitching Kitching NNP cord-326673-p8qbxi57 2 4 , , , cord-326673-p8qbxi57 2 5 R. R. NNP cord-326673-p8qbxi57 2 6 P. P. NNP cord-326673-p8qbxi57 2 7 ; ; : cord-326673-p8qbxi57 2 8 Salt Salt NNP cord-326673-p8qbxi57 2 9 , , , cord-326673-p8qbxi57 2 10 J. J. NNP cord-326673-p8qbxi57 2 11 S. S. NNP cord-326673-p8qbxi57 2 12 title title NN cord-326673-p8qbxi57 2 13 : : : cord-326673-p8qbxi57 3 1 The the DT cord-326673-p8qbxi57 3 2 interference interference NN cord-326673-p8qbxi57 3 3 by by IN cord-326673-p8qbxi57 3 4 maternally maternally RB cord-326673-p8qbxi57 3 5 - - HYPH cord-326673-p8qbxi57 3 6 derived derive VBN cord-326673-p8qbxi57 3 7 antibody antibody NN cord-326673-p8qbxi57 3 8 with with IN cord-326673-p8qbxi57 3 9 active active JJ cord-326673-p8qbxi57 3 10 immunization immunization NN cord-326673-p8qbxi57 3 11 of of IN cord-326673-p8qbxi57 3 12 farm farm NN cord-326673-p8qbxi57 3 13 animals animal NNS cord-326673-p8qbxi57 3 14 against against IN cord-326673-p8qbxi57 3 15 foot foot NN cord-326673-p8qbxi57 3 16 - - HYPH cord-326673-p8qbxi57 3 17 and and CC cord-326673-p8qbxi57 3 18 - - HYPH cord-326673-p8qbxi57 3 19 mouth mouth NN cord-326673-p8qbxi57 3 20 disease disease NN cord-326673-p8qbxi57 3 21 date date NN cord-326673-p8qbxi57 3 22 : : : cord-326673-p8qbxi57 3 23 1995 1995 CD cord-326673-p8qbxi57 3 24 - - SYM cord-326673-p8qbxi57 3 25 12 12 CD cord-326673-p8qbxi57 3 26 - - SYM cord-326673-p8qbxi57 3 27 31 31 CD cord-326673-p8qbxi57 3 28 journal journal NN cord-326673-p8qbxi57 3 29 : : : cord-326673-p8qbxi57 3 30 British British NNP cord-326673-p8qbxi57 3 31 Veterinary Veterinary NNP cord-326673-p8qbxi57 3 32 Journal Journal NNP cord-326673-p8qbxi57 3 33 DOI DOI NNP cord-326673-p8qbxi57 3 34 : : : cord-326673-p8qbxi57 3 35 10.1016 10.1016 CD cord-326673-p8qbxi57 3 36 / / SYM cord-326673-p8qbxi57 3 37 s0007 s0007 NN cord-326673-p8qbxi57 3 38 - - HYPH cord-326673-p8qbxi57 3 39 1935(95)80127 1935(95)80127 CD cord-326673-p8qbxi57 3 40 - - HYPH cord-326673-p8qbxi57 3 41 8 8 CD cord-326673-p8qbxi57 3 42 sha sha NN cord-326673-p8qbxi57 3 43 : : : cord-326673-p8qbxi57 4 1 b149eb40c3b58f04a6ebc5dd0adaab13e19fa572 b149eb40c3b58f04a6ebc5dd0adaab13e19fa572 NNP cord-326673-p8qbxi57 4 2 doc_id doc_id CD cord-326673-p8qbxi57 4 3 : : : cord-326673-p8qbxi57 4 4 326673 326673 CD cord-326673-p8qbxi57 4 5 cord_uid cord_uid NNS cord-326673-p8qbxi57 4 6 : : : cord-326673-p8qbxi57 5 1 p8qbxi57 p8qbxi57 NNP cord-326673-p8qbxi57 5 2 Summary Summary NNP cord-326673-p8qbxi57 5 3 Foot Foot NNP cord-326673-p8qbxi57 5 4 - - HYPH cord-326673-p8qbxi57 5 5 and and CC cord-326673-p8qbxi57 5 6 - - HYPH cord-326673-p8qbxi57 5 7 mouth mouth NN cord-326673-p8qbxi57 5 8 disease disease NN cord-326673-p8qbxi57 5 9 ( ( -LRB- cord-326673-p8qbxi57 5 10 FMD FMD NNP cord-326673-p8qbxi57 5 11 ) ) -RRB- cord-326673-p8qbxi57 5 12 is be VBZ cord-326673-p8qbxi57 5 13 a a DT cord-326673-p8qbxi57 5 14 highly highly RB cord-326673-p8qbxi57 5 15 contagious contagious JJ cord-326673-p8qbxi57 5 16 disease disease NN cord-326673-p8qbxi57 5 17 affectingruminants affectingruminant NNS cord-326673-p8qbxi57 5 18 and and CC cord-326673-p8qbxi57 5 19 pigs pig NNS cord-326673-p8qbxi57 5 20 . . . cord-326673-p8qbxi57 6 1 In in IN cord-326673-p8qbxi57 6 2 countries country NNS cord-326673-p8qbxi57 6 3 in in IN cord-326673-p8qbxi57 6 4 which which WDT cord-326673-p8qbxi57 6 5 control control NN cord-326673-p8qbxi57 6 6 of of IN cord-326673-p8qbxi57 6 7 FMD FMD NNP cord-326673-p8qbxi57 6 8 relies rely VBZ cord-326673-p8qbxi57 6 9 predominantly predominantly RB cord-326673-p8qbxi57 6 10 on on IN cord-326673-p8qbxi57 6 11 vaccination vaccination NN cord-326673-p8qbxi57 6 12 , , , cord-326673-p8qbxi57 6 13 young young JJ cord-326673-p8qbxi57 6 14 stock stock NN cord-326673-p8qbxi57 6 15 ingest ingest VBP cord-326673-p8qbxi57 6 16 specific specific JJ cord-326673-p8qbxi57 6 17 anti anti JJ cord-326673-p8qbxi57 6 18 - - JJ cord-326673-p8qbxi57 6 19 FMD FMD NNP cord-326673-p8qbxi57 6 20 virus virus NN cord-326673-p8qbxi57 6 21 antibodies antibody NNS cord-326673-p8qbxi57 6 22 in in IN cord-326673-p8qbxi57 6 23 the the DT cord-326673-p8qbxi57 6 24 colostrum colostrum NN cord-326673-p8qbxi57 6 25 . . . cord-326673-p8qbxi57 7 1 This this DT cord-326673-p8qbxi57 7 2 maternally maternally RB cord-326673-p8qbxi57 7 3 - - HYPH cord-326673-p8qbxi57 7 4 derived derive VBN cord-326673-p8qbxi57 7 5 antibody antibody NN cord-326673-p8qbxi57 7 6 ( ( -LRB- cord-326673-p8qbxi57 7 7 MDA MDA NNP cord-326673-p8qbxi57 7 8 ) ) -RRB- cord-326673-p8qbxi57 7 9 provides provide VBZ cord-326673-p8qbxi57 7 10 immediate immediate JJ cord-326673-p8qbxi57 7 11 protection protection NN cord-326673-p8qbxi57 7 12 against against IN cord-326673-p8qbxi57 7 13 infection infection NN cord-326673-p8qbxi57 7 14 with with IN cord-326673-p8qbxi57 7 15 FMD FMD NNP cord-326673-p8qbxi57 7 16 virus virus NN cord-326673-p8qbxi57 7 17 , , , cord-326673-p8qbxi57 7 18 but but CC cord-326673-p8qbxi57 7 19 also also RB cord-326673-p8qbxi57 7 20 interferes interfere VBZ cord-326673-p8qbxi57 7 21 with with IN cord-326673-p8qbxi57 7 22 the the DT cord-326673-p8qbxi57 7 23 development development NN cord-326673-p8qbxi57 7 24 of of IN cord-326673-p8qbxi57 7 25 active active JJ cord-326673-p8qbxi57 7 26 immunity immunity NN cord-326673-p8qbxi57 7 27 following follow VBG cord-326673-p8qbxi57 7 28 vaccination vaccination NN cord-326673-p8qbxi57 7 29 . . . cord-326673-p8qbxi57 8 1 However however RB cord-326673-p8qbxi57 8 2 , , , cord-326673-p8qbxi57 8 3 susceptibility susceptibility NN cord-326673-p8qbxi57 8 4 to to IN cord-326673-p8qbxi57 8 5 infection infection NN cord-326673-p8qbxi57 8 6 precedes precede VBZ cord-326673-p8qbxi57 8 7 the the DT cord-326673-p8qbxi57 8 8 ability ability NN cord-326673-p8qbxi57 8 9 to to TO cord-326673-p8qbxi57 8 10 respond respond VB cord-326673-p8qbxi57 8 11 to to IN cord-326673-p8qbxi57 8 12 vaccination vaccination NN cord-326673-p8qbxi57 8 13 in in IN cord-326673-p8qbxi57 8 14 the the DT cord-326673-p8qbxi57 8 15 presence presence NN cord-326673-p8qbxi57 8 16 of of IN cord-326673-p8qbxi57 8 17 MDA MDA NNP cord-326673-p8qbxi57 8 18 . . . cord-326673-p8qbxi57 9 1 Currently currently RB cord-326673-p8qbxi57 9 2 available available JJ cord-326673-p8qbxi57 9 3 vaccines vaccine NNS cord-326673-p8qbxi57 9 4 can can MD cord-326673-p8qbxi57 9 5 not not RB cord-326673-p8qbxi57 9 6 overcome overcome VB cord-326673-p8qbxi57 9 7 this this DT cord-326673-p8qbxi57 9 8 inhibitory inhibitory JJ cord-326673-p8qbxi57 9 9 effect effect NN cord-326673-p8qbxi57 9 10 of of IN cord-326673-p8qbxi57 9 11 MDA MDA NNP cord-326673-p8qbxi57 9 12 , , , cord-326673-p8qbxi57 9 13 and and CC cord-326673-p8qbxi57 9 14 protection protection NN cord-326673-p8qbxi57 9 15 of of IN cord-326673-p8qbxi57 9 16 young young JJ cord-326673-p8qbxi57 9 17 stock stock NN cord-326673-p8qbxi57 9 18 can can MD cord-326673-p8qbxi57 9 19 only only RB cord-326673-p8qbxi57 9 20 be be VB cord-326673-p8qbxi57 9 21 provided provide VBN cord-326673-p8qbxi57 9 22 by by IN cord-326673-p8qbxi57 9 23 their- their- NNS cord-326673-p8qbxi57 9 24 isolation isolation NN cord-326673-p8qbxi57 9 25 from from IN cord-326673-p8qbxi57 9 26 FMD FMD NNP cord-326673-p8qbxi57 9 27 virus virus NN cord-326673-p8qbxi57 9 28 . . . cord-326673-p8qbxi57 10 1 Neonates neonate NNS cord-326673-p8qbxi57 10 2 of of IN cord-326673-p8qbxi57 10 3 all all DT cord-326673-p8qbxi57 10 4 species specie NNS cord-326673-p8qbxi57 10 5 are be VBP cord-326673-p8qbxi57 10 6 born bear VBN cord-326673-p8qbxi57 10 7 into into IN cord-326673-p8qbxi57 10 8 a a DT cord-326673-p8qbxi57 10 9 hostile hostile JJ cord-326673-p8qbxi57 10 10 environment environment NN cord-326673-p8qbxi57 10 11 of of IN cord-326673-p8qbxi57 10 12 physical physical JJ cord-326673-p8qbxi57 10 13 and and CC cord-326673-p8qbxi57 10 14 biological biological JJ cord-326673-p8qbxi57 10 15 dangers danger NNS cord-326673-p8qbxi57 10 16 . . . cord-326673-p8qbxi57 11 1 The the DT cord-326673-p8qbxi57 11 2 obligate obligate JJ cord-326673-p8qbxi57 11 3 parasites parasite NNS cord-326673-p8qbxi57 11 4 in in IN cord-326673-p8qbxi57 11 5 particular particular JJ cord-326673-p8qbxi57 11 6 require require VBP cord-326673-p8qbxi57 11 7 to to TO cord-326673-p8qbxi57 11 8 infect infect VB cord-326673-p8qbxi57 11 9 new new JJ cord-326673-p8qbxi57 11 10 susceptible susceptible JJ cord-326673-p8qbxi57 11 11 individuals individual NNS cord-326673-p8qbxi57 11 12 in in IN cord-326673-p8qbxi57 11 13 order order NN cord-326673-p8qbxi57 11 14 to to TO cord-326673-p8qbxi57 11 15 ensure ensure VB cord-326673-p8qbxi57 11 16 their -PRON- PRP$ cord-326673-p8qbxi57 11 17 own own JJ cord-326673-p8qbxi57 11 18 survival survival NN cord-326673-p8qbxi57 11 19 . . . cord-326673-p8qbxi57 12 1 The the DT cord-326673-p8qbxi57 12 2 immune immune JJ cord-326673-p8qbxi57 12 3 system system NN cord-326673-p8qbxi57 12 4 has have VBZ cord-326673-p8qbxi57 12 5 developed develop VBN cord-326673-p8qbxi57 12 6 to to TO cord-326673-p8qbxi57 12 7 respond respond VB cord-326673-p8qbxi57 12 8 to to IN cord-326673-p8qbxi57 12 9 the the DT cord-326673-p8qbxi57 12 10 various various JJ cord-326673-p8qbxi57 12 11 strategies strategy NNS cord-326673-p8qbxi57 12 12 employed employ VBN cord-326673-p8qbxi57 12 13 by by IN cord-326673-p8qbxi57 12 14 these these DT cord-326673-p8qbxi57 12 15 pathogens pathogen NNS cord-326673-p8qbxi57 12 16 to to TO cord-326673-p8qbxi57 12 17 take take VB cord-326673-p8qbxi57 12 18 advantage advantage NN cord-326673-p8qbxi57 12 19 of of IN cord-326673-p8qbxi57 12 20 their -PRON- PRP$ cord-326673-p8qbxi57 12 21 intended intend VBN cord-326673-p8qbxi57 12 22 host host NN cord-326673-p8qbxi57 12 23 , , , cord-326673-p8qbxi57 12 24 and and CC cord-326673-p8qbxi57 12 25 consists consist VBZ cord-326673-p8qbxi57 12 26 of of IN cord-326673-p8qbxi57 12 27 a a DT cord-326673-p8qbxi57 12 28 number number NN cord-326673-p8qbxi57 12 29 of of IN cord-326673-p8qbxi57 12 30 different different JJ cord-326673-p8qbxi57 12 31 components component NNS cord-326673-p8qbxi57 12 32 which which WDT cord-326673-p8qbxi57 12 33 reflect reflect VBP cord-326673-p8qbxi57 12 34 the the DT cord-326673-p8qbxi57 12 35 varied varied JJ cord-326673-p8qbxi57 12 36 and and CC cord-326673-p8qbxi57 12 37 diverse diverse JJ cord-326673-p8qbxi57 12 38 methods method NNS cord-326673-p8qbxi57 12 39 of of IN cord-326673-p8qbxi57 12 40 enuy enuy NN cord-326673-p8qbxi57 12 41 and and CC cord-326673-p8qbxi57 12 42 establishment establishment NN cord-326673-p8qbxi57 12 43 that that WDT cord-326673-p8qbxi57 12 44 have have VBP cord-326673-p8qbxi57 12 45 evolved evolve VBN cord-326673-p8qbxi57 12 46 . . . cord-326673-p8qbxi57 13 1 However however RB cord-326673-p8qbxi57 13 2 , , , cord-326673-p8qbxi57 13 3 not not RB cord-326673-p8qbxi57 13 4 only only RB cord-326673-p8qbxi57 13 5 are be VBP cord-326673-p8qbxi57 13 6 the the DT cord-326673-p8qbxi57 13 7 different different JJ cord-326673-p8qbxi57 13 8 species specie NNS cord-326673-p8qbxi57 13 9 of of IN cord-326673-p8qbxi57 13 10 farm farm NN cord-326673-p8qbxi57 13 11 animal animal NN cord-326673-p8qbxi57 13 12 born bear VBN cord-326673-p8qbxi57 13 13 with with IN cord-326673-p8qbxi57 13 14 their -PRON- PRP$ cord-326673-p8qbxi57 13 15 immune immune JJ cord-326673-p8qbxi57 13 16 system system NN cord-326673-p8qbxi57 13 17 at at IN cord-326673-p8qbxi57 13 18 different different JJ cord-326673-p8qbxi57 13 19 levels level NNS cord-326673-p8qbxi57 13 20 of of IN cord-326673-p8qbxi57 13 21 maturity maturity NN cord-326673-p8qbxi57 13 22 , , , cord-326673-p8qbxi57 13 23 the the DT cord-326673-p8qbxi57 13 24 different different JJ cord-326673-p8qbxi57 13 25 parts part NNS cord-326673-p8qbxi57 13 26 of of IN cord-326673-p8qbxi57 13 27 the the DT cord-326673-p8qbxi57 13 28 complete complete JJ cord-326673-p8qbxi57 13 29 system system NN cord-326673-p8qbxi57 13 30 do do VBP cord-326673-p8qbxi57 13 31 not not RB cord-326673-p8qbxi57 13 32 become become VB cord-326673-p8qbxi57 13 33 functional functional JJ cord-326673-p8qbxi57 13 34 simultaneously simultaneously RB cord-326673-p8qbxi57 13 35 . . . cord-326673-p8qbxi57 14 1 At at IN cord-326673-p8qbxi57 14 2 birth birth NN cord-326673-p8qbxi57 14 3 , , , cord-326673-p8qbxi57 14 4 the the DT cord-326673-p8qbxi57 14 5 calf calf NN cord-326673-p8qbxi57 14 6 can can MD cord-326673-p8qbxi57 14 7 immunologically immunologically RB cord-326673-p8qbxi57 14 8 respond respond VB cord-326673-p8qbxi57 14 9 to to IN cord-326673-p8qbxi57 14 10 bluetongue bluetongue NN cord-326673-p8qbxi57 14 11 virus virus NN cord-326673-p8qbxi57 14 12 ( ( -LRB- cord-326673-p8qbxi57 15 1 MacLachlan MacLachlan NNP cord-326673-p8qbxi57 15 2 el el NNP cord-326673-p8qbxi57 15 3 al al NNP cord-326673-p8qbxi57 15 4 . . . cord-326673-p8qbxi57 16 1 , , , cord-326673-p8qbxi57 16 2 1984 1984 CD cord-326673-p8qbxi57 16 3 ) ) -RRB- cord-326673-p8qbxi57 16 4 and and CC cord-326673-p8qbxi57 16 5 foot foot NN cord-326673-p8qbxi57 16 6 - - HYPH cord-326673-p8qbxi57 16 7 and and CC cord-326673-p8qbxi57 16 8 - - HYPH cord-326673-p8qbxi57 16 9 mouth mouth NN cord-326673-p8qbxi57 16 10 disease disease NN cord-326673-p8qbxi57 16 11 ( ( -LRB- cord-326673-p8qbxi57 16 12 FMD FMD NNP cord-326673-p8qbxi57 16 13 ) ) -RRB- cord-326673-p8qbxi57 16 14 virus virus NN cord-326673-p8qbxi57 17 1 ( ( -LRB- cord-326673-p8qbxi57 17 2 Nicholls Nicholls NNP cord-326673-p8qbxi57 17 3 et et NNP cord-326673-p8qbxi57 17 4 al al NNP cord-326673-p8qbxi57 17 5 . . NNP cord-326673-p8qbxi57 17 6 , , , cord-326673-p8qbxi57 17 7 1985 1985 CD cord-326673-p8qbxi57 17 8 ) ) -RRB- cord-326673-p8qbxi57 17 9 by by IN cord-326673-p8qbxi57 17 10 producing produce VBG cord-326673-p8qbxi57 17 11 neutralizing neutralize VBG cord-326673-p8qbxi57 17 12 antibody antibody NN cord-326673-p8qbxi57 17 13 , , , cord-326673-p8qbxi57 17 14 but but CC cord-326673-p8qbxi57 17 15 can can MD cord-326673-p8qbxi57 17 16 only only RB cord-326673-p8qbxi57 17 17 partially partially RB cord-326673-p8qbxi57 17 18 respond respond VB cord-326673-p8qbxi57 17 19 to to IN cord-326673-p8qbxi57 17 20 infection infection NN cord-326673-p8qbxi57 17 21 with with IN cord-326673-p8qbxi57 17 22 parainfluenza-3 parainfluenza-3 NNP cord-326673-p8qbxi57 17 23 virus virus NN cord-326673-p8qbxi57 17 24 ( ( -LRB- cord-326673-p8qbxi57 17 25 Thorsen Thorsen NNP cord-326673-p8qbxi57 17 26 et et NNP cord-326673-p8qbxi57 17 27 al al NNP cord-326673-p8qbxi57 17 28 . . NNP cord-326673-p8qbxi57 17 29 , , , cord-326673-p8qbxi57 17 30 1969 1969 CD cord-326673-p8qbxi57 17 31 ) ) -RRB- cord-326673-p8qbxi57 17 32 . . . cord-326673-p8qbxi57 18 1 Experimental experimental JJ cord-326673-p8qbxi57 18 2 infection infection NN cord-326673-p8qbxi57 18 3 of of IN cord-326673-p8qbxi57 18 4 the the DT cord-326673-p8qbxi57 18 5 foetal foetal JJ cord-326673-p8qbxi57 18 6 calf calf NN cord-326673-p8qbxi57 18 7 has have VBZ cord-326673-p8qbxi57 18 8 been be VBN cord-326673-p8qbxi57 18 9 used use VBN cord-326673-p8qbxi57 18 10 to to TO cord-326673-p8qbxi57 18 11 show show VB cord-326673-p8qbxi57 18 12 how how WRB cord-326673-p8qbxi57 18 13 the the DT cord-326673-p8qbxi57 18 14 developing develop VBG cord-326673-p8qbxi57 18 15 immune immune JJ cord-326673-p8qbxi57 18 16 system system NN cord-326673-p8qbxi57 18 17 0007- 0007- CD cord-326673-p8qbxi57 19 1 1935/95/040379 1935/95/040379 CD cord-326673-p8qbxi57 19 2 - - SYM cord-326673-p8qbxi57 19 3 11/$08.00/0 11/$08.00/0 CD cord-326673-p8qbxi57 19 4 © © NN cord-326673-p8qbxi57 19 5 1995 1995 CD cord-326673-p8qbxi57 19 6 Bailli Bailli NNP cord-326673-p8qbxi57 19 7 ~ ~ NFP cord-326673-p8qbxi57 19 8 re re IN cord-326673-p8qbxi57 19 9 Tindall Tindall NNP cord-326673-p8qbxi57 19 10 responds respond VBZ cord-326673-p8qbxi57 19 11 to to IN cord-326673-p8qbxi57 19 12 different different JJ cord-326673-p8qbxi57 19 13 antigens antigen NNS cord-326673-p8qbxi57 19 14 during during IN cord-326673-p8qbxi57 19 15 its -PRON- PRP$ cord-326673-p8qbxi57 19 16 ontogeny ontogeny NN cord-326673-p8qbxi57 19 17 ( ( -LRB- cord-326673-p8qbxi57 19 18 see see VB cord-326673-p8qbxi57 19 19 review review NN cord-326673-p8qbxi57 19 20 by by IN cord-326673-p8qbxi57 19 21 Osburn Osburn NNP cord-326673-p8qbxi57 19 22 , , , cord-326673-p8qbxi57 19 23 1986 1986 CD cord-326673-p8qbxi57 19 24 ) ) -RRB- cord-326673-p8qbxi57 19 25 . . . cord-326673-p8qbxi57 20 1 The the DT cord-326673-p8qbxi57 20 2 immune immune JJ cord-326673-p8qbxi57 20 3 system system NN cord-326673-p8qbxi57 20 4 of of IN cord-326673-p8qbxi57 20 5 the the DT cord-326673-p8qbxi57 20 6 pig pig NN cord-326673-p8qbxi57 20 7 is be VBZ cord-326673-p8qbxi57 20 8 less less RBR cord-326673-p8qbxi57 20 9 mature mature JJ cord-326673-p8qbxi57 20 10 at at IN cord-326673-p8qbxi57 20 11 birth birth NN cord-326673-p8qbxi57 20 12 ; ; : cord-326673-p8qbxi57 20 13 it -PRON- PRP cord-326673-p8qbxi57 20 14 can can MD cord-326673-p8qbxi57 20 15 respond respond VB cord-326673-p8qbxi57 20 16 to to TO cord-326673-p8qbxi57 20 17 hog hog VB cord-326673-p8qbxi57 20 18 cholera cholera NN cord-326673-p8qbxi57 20 19 vaccination vaccination NN cord-326673-p8qbxi57 20 20 at at IN cord-326673-p8qbxi57 20 21 1 1 CD cord-326673-p8qbxi57 20 22 week week NN cord-326673-p8qbxi57 20 23 of of IN cord-326673-p8qbxi57 20 24 age age NN cord-326673-p8qbxi57 20 25 ( ( -LRB- cord-326673-p8qbxi57 20 26 Precausta Precausta NNP cord-326673-p8qbxi57 20 27 et et NNP cord-326673-p8qbxi57 20 28 al al NNP cord-326673-p8qbxi57 20 29 . . NNP cord-326673-p8qbxi57 20 30 , , , cord-326673-p8qbxi57 20 31 1983 1983 CD cord-326673-p8qbxi57 20 32 ) ) -RRB- cord-326673-p8qbxi57 20 33 but but CC cord-326673-p8qbxi57 20 34 not not RB cord-326673-p8qbxi57 20 35 effectively effectively RB cord-326673-p8qbxi57 20 36 to to IN cord-326673-p8qbxi57 20 37 FMD FMD NNP cord-326673-p8qbxi57 20 38 vaccination vaccination NN cord-326673-p8qbxi57 20 39 until until IN cord-326673-p8qbxi57 20 40 2 2 CD cord-326673-p8qbxi57 20 41 weeks week NNS cord-326673-p8qbxi57 20 42 after after IN cord-326673-p8qbxi57 20 43 birth birth NN cord-326673-p8qbxi57 21 1 ( ( -LRB- cord-326673-p8qbxi57 21 2 Francis Francis NNP cord-326673-p8qbxi57 21 3 & & CC cord-326673-p8qbxi57 21 4 Black Black NNP cord-326673-p8qbxi57 21 5 , , , cord-326673-p8qbxi57 21 6 1986 1986 CD cord-326673-p8qbxi57 21 7 ) ) -RRB- cord-326673-p8qbxi57 21 8 . . . cord-326673-p8qbxi57 22 1 However however RB cord-326673-p8qbxi57 22 2 , , , cord-326673-p8qbxi57 22 3 despite despite IN cord-326673-p8qbxi57 22 4 the the DT cord-326673-p8qbxi57 22 5 development development NN cord-326673-p8qbxi57 22 6 of of IN cord-326673-p8qbxi57 22 7 a a DT cord-326673-p8qbxi57 22 8 functionally functionally RB cord-326673-p8qbxi57 22 9 competent competent JJ cord-326673-p8qbxi57 22 10 immune immune JJ cord-326673-p8qbxi57 22 11 system system NN cord-326673-p8qbxi57 22 12 , , , cord-326673-p8qbxi57 22 13 there there EX cord-326673-p8qbxi57 22 14 is be VBZ cord-326673-p8qbxi57 22 15 inevitably inevitably RB cord-326673-p8qbxi57 22 16 a a DT cord-326673-p8qbxi57 22 17 lag lag NN cord-326673-p8qbxi57 22 18 period period NN cord-326673-p8qbxi57 22 19 between between IN cord-326673-p8qbxi57 22 20 immunization immunization NN cord-326673-p8qbxi57 22 21 and and CC cord-326673-p8qbxi57 22 22 the the DT cord-326673-p8qbxi57 22 23 development development NN cord-326673-p8qbxi57 22 24 of of IN cord-326673-p8qbxi57 22 25 active active JJ cord-326673-p8qbxi57 22 26 immunity immunity NN cord-326673-p8qbxi57 22 27 . . . cord-326673-p8qbxi57 23 1 It -PRON- PRP cord-326673-p8qbxi57 23 2 is be VBZ cord-326673-p8qbxi57 23 3 during during IN cord-326673-p8qbxi57 23 4 this this DT cord-326673-p8qbxi57 23 5 period period NN cord-326673-p8qbxi57 23 6 that that IN cord-326673-p8qbxi57 23 7 prevalent prevalent JJ cord-326673-p8qbxi57 23 8 viruses virus NNS cord-326673-p8qbxi57 23 9 can can MD cord-326673-p8qbxi57 23 10 establish establish VB cord-326673-p8qbxi57 23 11 themselves -PRON- PRP cord-326673-p8qbxi57 23 12 in in IN cord-326673-p8qbxi57 23 13 young young JJ cord-326673-p8qbxi57 23 14 animals animal NNS cord-326673-p8qbxi57 23 15 . . . cord-326673-p8qbxi57 24 1 Irnmediate irnmediate JJ cord-326673-p8qbxi57 24 2 immunity immunity NN cord-326673-p8qbxi57 24 3 in in IN cord-326673-p8qbxi57 24 4 the the DT cord-326673-p8qbxi57 24 5 newborn newborn JJ cord-326673-p8qbxi57 24 6 pig pig NN cord-326673-p8qbxi57 24 7 or or CC cord-326673-p8qbxi57 24 8 ruminant ruminant NN cord-326673-p8qbxi57 24 9 is be VBZ cord-326673-p8qbxi57 24 10 provided provide VBN cord-326673-p8qbxi57 24 11 in in IN cord-326673-p8qbxi57 24 12 the the DT cord-326673-p8qbxi57 24 13 colostrum colostrum NN cord-326673-p8qbxi57 24 14 of of IN cord-326673-p8qbxi57 24 15 the the DT cord-326673-p8qbxi57 24 16 dana dana NNP cord-326673-p8qbxi57 24 17 . . . cord-326673-p8qbxi57 25 1 All all DT cord-326673-p8qbxi57 25 2 classes class NNS cord-326673-p8qbxi57 25 3 of of IN cord-326673-p8qbxi57 25 4 antibody antibody NN cord-326673-p8qbxi57 25 5 are be VBP cord-326673-p8qbxi57 25 6 present present JJ cord-326673-p8qbxi57 25 7 , , , cord-326673-p8qbxi57 25 8 in in IN cord-326673-p8qbxi57 25 9 concentrations concentration NNS cord-326673-p8qbxi57 25 10 greater great JJR cord-326673-p8qbxi57 25 11 than than IN cord-326673-p8qbxi57 25 12 those those DT cord-326673-p8qbxi57 25 13 present present JJ cord-326673-p8qbxi57 25 14 in in IN cord-326673-p8qbxi57 25 15 the the DT cord-326673-p8qbxi57 25 16 parental parental JJ cord-326673-p8qbxi57 25 17 blood blood NN cord-326673-p8qbxi57 25 18 , , , cord-326673-p8qbxi57 25 19 together together RB cord-326673-p8qbxi57 25 20 with with IN cord-326673-p8qbxi57 25 21 immunologically immunologically RB cord-326673-p8qbxi57 25 22 active active JJ cord-326673-p8qbxi57 25 23 cells cell NNS cord-326673-p8qbxi57 25 24 . . . cord-326673-p8qbxi57 26 1 The the DT cord-326673-p8qbxi57 26 2 specificity specificity NN cord-326673-p8qbxi57 26 3 of of IN cord-326673-p8qbxi57 26 4 this this DT cord-326673-p8qbxi57 26 5 antibody antibody NN cord-326673-p8qbxi57 26 6 reflects reflect VBZ cord-326673-p8qbxi57 26 7 the the DT cord-326673-p8qbxi57 26 8 vaccination vaccination NN cord-326673-p8qbxi57 26 9 and and CC cord-326673-p8qbxi57 26 10 disease disease NN cord-326673-p8qbxi57 26 11 history history NN cord-326673-p8qbxi57 26 12 of of IN cord-326673-p8qbxi57 26 13 the the DT cord-326673-p8qbxi57 26 14 dana dana NNP cord-326673-p8qbxi57 26 15 , , , cord-326673-p8qbxi57 26 16 and and CC cord-326673-p8qbxi57 26 17 therefore therefore RB cord-326673-p8qbxi57 26 18 , , , cord-326673-p8qbxi57 26 19 by by IN cord-326673-p8qbxi57 26 20 boosting boost VBG cord-326673-p8qbxi57 26 21 the the DT cord-326673-p8qbxi57 26 22 antibody antibody NN cord-326673-p8qbxi57 26 23 levels level NNS cord-326673-p8qbxi57 26 24 to to IN cord-326673-p8qbxi57 26 25 those those DT cord-326673-p8qbxi57 26 26 pathogens pathogen NNS cord-326673-p8qbxi57 26 27 associated associate VBN cord-326673-p8qbxi57 26 28 with with IN cord-326673-p8qbxi57 26 29 neonatal neonatal JJ cord-326673-p8qbxi57 26 30 mortality mortality NN cord-326673-p8qbxi57 26 31 through through IN cord-326673-p8qbxi57 26 32 vaccination vaccination NN cord-326673-p8qbxi57 26 33 , , , cord-326673-p8qbxi57 26 34 the the DT cord-326673-p8qbxi57 26 35 newborn newborn JJ cord-326673-p8qbxi57 26 36 animal animal NN cord-326673-p8qbxi57 26 37 can can MD cord-326673-p8qbxi57 26 38 receive receive VB cord-326673-p8qbxi57 26 39 from from IN cord-326673-p8qbxi57 26 40 its -PRON- PRP$ cord-326673-p8qbxi57 26 41 mother mother NN cord-326673-p8qbxi57 26 42 high high JJ cord-326673-p8qbxi57 26 43 levels level NNS cord-326673-p8qbxi57 26 44 of of IN cord-326673-p8qbxi57 26 45 specific specific JJ cord-326673-p8qbxi57 26 46 protection protection NN cord-326673-p8qbxi57 26 47 . . . cord-326673-p8qbxi57 27 1 However however RB cord-326673-p8qbxi57 27 2 , , , cord-326673-p8qbxi57 27 3 this this DT cord-326673-p8qbxi57 27 4 maternally maternally RB cord-326673-p8qbxi57 27 5 derived derive VBN cord-326673-p8qbxi57 27 6 antibody antibody NN cord-326673-p8qbxi57 27 7 ( ( -LRB- cord-326673-p8qbxi57 27 8 MDA MDA NNP cord-326673-p8qbxi57 27 9 ) ) -RRB- cord-326673-p8qbxi57 27 10 is be VBZ cord-326673-p8qbxi57 27 11 equally equally RB cord-326673-p8qbxi57 27 12 effective effective JJ cord-326673-p8qbxi57 27 13 in in IN cord-326673-p8qbxi57 27 14 preventing prevent VBG cord-326673-p8qbxi57 27 15 the the DT cord-326673-p8qbxi57 27 16 response response NN cord-326673-p8qbxi57 27 17 to to IN cord-326673-p8qbxi57 27 18 active active JJ cord-326673-p8qbxi57 27 19 vaccination vaccination NN cord-326673-p8qbxi57 27 20 in in IN cord-326673-p8qbxi57 27 21 the the DT cord-326673-p8qbxi57 27 22 young young JJ cord-326673-p8qbxi57 27 23 animal animal NN cord-326673-p8qbxi57 27 24 as as IN cord-326673-p8qbxi57 27 25 it -PRON- PRP cord-326673-p8qbxi57 27 26 is be VBZ cord-326673-p8qbxi57 27 27 in in IN cord-326673-p8qbxi57 27 28 providing provide VBG cord-326673-p8qbxi57 27 29 protection protection NN cord-326673-p8qbxi57 27 30 against against IN cord-326673-p8qbxi57 27 31 disease disease NN cord-326673-p8qbxi57 27 32 . . . cord-326673-p8qbxi57 28 1 Unlike unlike IN cord-326673-p8qbxi57 28 2 the the DT cord-326673-p8qbxi57 28 3 situation situation NN cord-326673-p8qbxi57 28 4 in in IN cord-326673-p8qbxi57 28 5 primates primate NNS cord-326673-p8qbxi57 28 6 , , , cord-326673-p8qbxi57 28 7 transfer transfer NN cord-326673-p8qbxi57 28 8 of of IN cord-326673-p8qbxi57 28 9 immunoglobulins immunoglobulin NNS cord-326673-p8qbxi57 28 10 across across IN cord-326673-p8qbxi57 28 11 the the DT cord-326673-p8qbxi57 28 12 epitheliochorial epitheliochorial JJ cord-326673-p8qbxi57 28 13 placenta placenta NN cord-326673-p8qbxi57 28 14 of of IN cord-326673-p8qbxi57 28 15 farm farm NN cord-326673-p8qbxi57 28 16 animals animal NNS cord-326673-p8qbxi57 28 17 during during IN cord-326673-p8qbxi57 28 18 pregnancy pregnancy NN cord-326673-p8qbxi57 28 19 is be VBZ cord-326673-p8qbxi57 28 20 not not RB cord-326673-p8qbxi57 28 21 possible possible JJ cord-326673-p8qbxi57 28 22 . . . cord-326673-p8qbxi57 29 1 Early early JJ cord-326673-p8qbxi57 29 2 passive passive JJ cord-326673-p8qbxi57 29 3 immunity immunity NN cord-326673-p8qbxi57 29 4 in in IN cord-326673-p8qbxi57 29 5 these these DT cord-326673-p8qbxi57 29 6 species specie NNS cord-326673-p8qbxi57 29 7 is be VBZ cord-326673-p8qbxi57 29 8 transferred transfer VBN cord-326673-p8qbxi57 29 9 to to IN cord-326673-p8qbxi57 29 10 the the DT cord-326673-p8qbxi57 29 11 offspring offspring NN cord-326673-p8qbxi57 29 12 posl posl NN cord-326673-p8qbxi57 29 13 - - HYPH cord-326673-p8qbxi57 29 14 partum partum NN cord-326673-p8qbxi57 29 15 by by IN cord-326673-p8qbxi57 29 16 the the DT cord-326673-p8qbxi57 29 17 absorption absorption NN cord-326673-p8qbxi57 29 18 of of IN cord-326673-p8qbxi57 29 19 colostrum colostrum NN cord-326673-p8qbxi57 29 20 through through IN cord-326673-p8qbxi57 29 21 the the DT cord-326673-p8qbxi57 29 22 gut gut NN cord-326673-p8qbxi57 29 23 mucosa mucosa JJ cord-326673-p8qbxi57 29 24 . . . cord-326673-p8qbxi57 30 1 In in IN cord-326673-p8qbxi57 30 2 the the DT cord-326673-p8qbxi57 30 3 calf calf NN cord-326673-p8qbxi57 30 4 and and CC cord-326673-p8qbxi57 30 5 piglet piglet NN cord-326673-p8qbxi57 30 6 an an DT cord-326673-p8qbxi57 30 7 indiscriminate indiscriminate JJ cord-326673-p8qbxi57 30 8 uptake uptake NN cord-326673-p8qbxi57 30 9 by by IN cord-326673-p8qbxi57 30 10 the the DT cord-326673-p8qbxi57 30 11 gut gut NN cord-326673-p8qbxi57 30 12 epithelium epithelium NN cord-326673-p8qbxi57 30 13 of of IN cord-326673-p8qbxi57 30 14 macromolecules macromolecule NNS cord-326673-p8qbxi57 30 15 and and CC cord-326673-p8qbxi57 30 16 immunocompetent immunocompetent JJ cord-326673-p8qbxi57 30 17 cells cell NNS cord-326673-p8qbxi57 30 18 in in IN cord-326673-p8qbxi57 30 19 colostrum colostrum NN cord-326673-p8qbxi57 30 20 is be VBZ cord-326673-p8qbxi57 30 21 possible possible JJ cord-326673-p8qbxi57 30 22 for for IN cord-326673-p8qbxi57 30 23 the the DT cord-326673-p8qbxi57 30 24 first first JJ cord-326673-p8qbxi57 30 25 24 24 CD cord-326673-p8qbxi57 30 26 - - SYM cord-326673-p8qbxi57 30 27 36 36 CD cord-326673-p8qbxi57 30 28 h h NN cord-326673-p8qbxi57 30 29 of of IN cord-326673-p8qbxi57 30 30 life life NN cord-326673-p8qbxi57 30 31 ( ( -LRB- cord-326673-p8qbxi57 30 32 Logan Logan NNP cord-326673-p8qbxi57 30 33 el el NNP cord-326673-p8qbxi57 30 34 aL aL NNP cord-326673-p8qbxi57 30 35 , , , cord-326673-p8qbxi57 30 36 1973 1973 CD cord-326673-p8qbxi57 30 37 ) ) -RRB- cord-326673-p8qbxi57 30 38 . . . cord-326673-p8qbxi57 31 1 The the DT cord-326673-p8qbxi57 31 2 process process NN cord-326673-p8qbxi57 31 3 is be VBZ cord-326673-p8qbxi57 31 4 non non JJ cord-326673-p8qbxi57 31 5 - - JJ cord-326673-p8qbxi57 31 6 selective selective JJ cord-326673-p8qbxi57 31 7 and and CC cord-326673-p8qbxi57 31 8 is be VBZ cord-326673-p8qbxi57 31 9 responsible responsible JJ cord-326673-p8qbxi57 31 10 for for IN cord-326673-p8qbxi57 31 11 the the DT cord-326673-p8qbxi57 31 12 rapid rapid JJ cord-326673-p8qbxi57 31 13 increase increase NN cord-326673-p8qbxi57 31 14 of of IN cord-326673-p8qbxi57 31 15 IgA IgA NNP cord-326673-p8qbxi57 31 16 , , , cord-326673-p8qbxi57 31 17 IgG IgG NNP cord-326673-p8qbxi57 31 18 and and CC cord-326673-p8qbxi57 31 19 IgM IgM NNP cord-326673-p8qbxi57 31 20 in in IN cord-326673-p8qbxi57 31 21 the the DT cord-326673-p8qbxi57 31 22 circulation circulation NN cord-326673-p8qbxi57 31 23 of of IN cord-326673-p8qbxi57 31 24 the the DT cord-326673-p8qbxi57 31 25 suckling suckle VBG cord-326673-p8qbxi57 31 26 neonate neonate NN cord-326673-p8qbxi57 31 27 , , , cord-326673-p8qbxi57 31 28 with with IN cord-326673-p8qbxi57 31 29 peak peak NN cord-326673-p8qbxi57 31 30 titres titre NNS cord-326673-p8qbxi57 31 31 occurring occur VBG cord-326673-p8qbxi57 31 32 at at IN cord-326673-p8qbxi57 31 33 24 24 CD cord-326673-p8qbxi57 31 34 - - SYM cord-326673-p8qbxi57 31 35 72 72 CD cord-326673-p8qbxi57 31 36 h h NN cord-326673-p8qbxi57 31 37 postpartum postpartum NN cord-326673-p8qbxi57 31 38 . . . cord-326673-p8qbxi57 32 1 The the DT cord-326673-p8qbxi57 32 2 persistent persistent JJ cord-326673-p8qbxi57 32 3 detection detection NN cord-326673-p8qbxi57 32 4 of of IN cord-326673-p8qbxi57 32 5 MDA MDA NNP cord-326673-p8qbxi57 32 6 in in IN cord-326673-p8qbxi57 32 7 the the DT cord-326673-p8qbxi57 32 8 serum serum NN cord-326673-p8qbxi57 32 9 and and CC cord-326673-p8qbxi57 32 10 secretions secretion NNS cord-326673-p8qbxi57 32 11 of of IN cord-326673-p8qbxi57 32 12 the the DT cord-326673-p8qbxi57 32 13 offspring offspring NN cord-326673-p8qbxi57 32 14 is be VBZ cord-326673-p8qbxi57 32 15 dependent dependent JJ cord-326673-p8qbxi57 32 16 upon upon IN cord-326673-p8qbxi57 32 17 the the DT cord-326673-p8qbxi57 32 18 initial initial JJ cord-326673-p8qbxi57 32 19 colostral colostral JJ cord-326673-p8qbxi57 32 20 uptake uptake NN cord-326673-p8qbxi57 32 21 , , , cord-326673-p8qbxi57 32 22 which which WDT cord-326673-p8qbxi57 32 23 is be VBZ cord-326673-p8qbxi57 32 24 determined determine VBN cord-326673-p8qbxi57 32 25 by by IN cord-326673-p8qbxi57 32 26 the the DT cord-326673-p8qbxi57 32 27 immune immune JJ cord-326673-p8qbxi57 32 28 status status NN cord-326673-p8qbxi57 32 29 of of IN cord-326673-p8qbxi57 32 30 the the DT cord-326673-p8qbxi57 32 31 mother mother NN cord-326673-p8qbxi57 32 32 , , , cord-326673-p8qbxi57 32 33 and and CC cord-326673-p8qbxi57 32 34 the the DT cord-326673-p8qbxi57 32 35 half half JJ cord-326673-p8qbxi57 32 36 - - HYPH cord-326673-p8qbxi57 32 37 life life NN cord-326673-p8qbxi57 32 38 of of IN cord-326673-p8qbxi57 32 39 antibody antibody NN cord-326673-p8qbxi57 32 40 in in IN cord-326673-p8qbxi57 32 41 the the DT cord-326673-p8qbxi57 32 42 offspring offspring NN cord-326673-p8qbxi57 32 43 , , , cord-326673-p8qbxi57 32 44 which which WDT cord-326673-p8qbxi57 32 45 is be VBZ cord-326673-p8qbxi57 32 46 different different JJ cord-326673-p8qbxi57 32 47 for for IN cord-326673-p8qbxi57 32 48 each each DT cord-326673-p8qbxi57 32 49 isotype isotype NN cord-326673-p8qbxi57 32 50 . . . cord-326673-p8qbxi57 33 1 MDA MDA NNP cord-326673-p8qbxi57 33 2 specific specific JJ cord-326673-p8qbxi57 33 3 for for IN cord-326673-p8qbxi57 33 4 FMD FMD NNP cord-326673-p8qbxi57 33 5 virus virus NN cord-326673-p8qbxi57 33 6 has have VBZ cord-326673-p8qbxi57 33 7 been be VBN cord-326673-p8qbxi57 33 8 found find VBN cord-326673-p8qbxi57 33 9 to to TO cord-326673-p8qbxi57 33 10 persist persist VB cord-326673-p8qbxi57 33 11 for for IN cord-326673-p8qbxi57 33 12 up up IN cord-326673-p8qbxi57 33 13 to to TO cord-326673-p8qbxi57 33 14 5 5 CD cord-326673-p8qbxi57 33 15 months month NNS cord-326673-p8qbxi57 33 16 in in IN cord-326673-p8qbxi57 33 17 calves calf NNS cord-326673-p8qbxi57 33 18 and and CC cord-326673-p8qbxi57 33 19 2 2 CD cord-326673-p8qbxi57 33 20 months month NNS cord-326673-p8qbxi57 33 21 in in IN cord-326673-p8qbxi57 33 22 piglets piglet NNS cord-326673-p8qbxi57 33 23 ( ( -LRB- cord-326673-p8qbxi57 33 24 Mll Mll NNP cord-326673-p8qbxi57 33 25 & & CC cord-326673-p8qbxi57 33 26 Wittman Wittman NNP cord-326673-p8qbxi57 33 27 , , , cord-326673-p8qbxi57 33 28 1987 1987 CD cord-326673-p8qbxi57 33 29 ) ) -RRB- cord-326673-p8qbxi57 33 30 . . . cord-326673-p8qbxi57 34 1 Estimations estimation NNS cord-326673-p8qbxi57 34 2 of of IN cord-326673-p8qbxi57 34 3 the the DT cord-326673-p8qbxi57 34 4 half half NN cord-326673-p8qbxi57 34 5 - - HYPH cord-326673-p8qbxi57 34 6 lives life NNS cord-326673-p8qbxi57 34 7 of of IN cord-326673-p8qbxi57 34 8 individual individual JJ cord-326673-p8qbxi57 34 9 MDA MDA NNP cord-326673-p8qbxi57 34 10 isotypes isotype NNS cord-326673-p8qbxi57 34 11 vary vary VBP cord-326673-p8qbxi57 34 12 . . . cord-326673-p8qbxi57 35 1 One one CD cord-326673-p8qbxi57 35 2 set set NN cord-326673-p8qbxi57 35 3 of of IN cord-326673-p8qbxi57 35 4 values value NNS cord-326673-p8qbxi57 35 5 for for IN cord-326673-p8qbxi57 35 6 the the DT cord-326673-p8qbxi57 35 7 calf calf NN cord-326673-p8qbxi57 35 8 gives give VBZ cord-326673-p8qbxi57 35 9 figures figure NNS cord-326673-p8qbxi57 35 10 of of IN cord-326673-p8qbxi57 35 11 2.8 2.8 CD cord-326673-p8qbxi57 35 12 days day NNS cord-326673-p8qbxi57 35 13 for for IN cord-326673-p8qbxi57 35 14 IgA IgA NNP cord-326673-p8qbxi57 35 15 , , , cord-326673-p8qbxi57 35 16 4.8 4.8 CD cord-326673-p8qbxi57 35 17 days day NNS cord-326673-p8qbxi57 35 18 for for IN cord-326673-p8qbxi57 35 19 IgM IgM NNP cord-326673-p8qbxi57 35 20 and and CC cord-326673-p8qbxi57 35 21 20 20 CD cord-326673-p8qbxi57 35 22 days day NNS cord-326673-p8qbxi57 35 23 for for IN cord-326673-p8qbxi57 35 24 IgG IgG NNP cord-326673-p8qbxi57 35 25 ( ( -LRB- cord-326673-p8qbxi57 35 26 Banks bank NNS cord-326673-p8qbxi57 35 27 , , , cord-326673-p8qbxi57 35 28 1982 1982 CD cord-326673-p8qbxi57 35 29 ) ) -RRB- cord-326673-p8qbxi57 35 30 . . . cord-326673-p8qbxi57 36 1 The the DT cord-326673-p8qbxi57 36 2 corresponding correspond VBG cord-326673-p8qbxi57 36 3 figures figure NNS cord-326673-p8qbxi57 36 4 for for IN cord-326673-p8qbxi57 36 5 pigs pig NNS cord-326673-p8qbxi57 36 6 are be VBP cord-326673-p8qbxi57 36 7 2.1 2.1 CD cord-326673-p8qbxi57 36 8 - - SYM cord-326673-p8qbxi57 36 9 3.0 3.0 CD cord-326673-p8qbxi57 36 10 days day NNS cord-326673-p8qbxi57 36 11 for for IN cord-326673-p8qbxi57 36 12 IgA IgA NNP cord-326673-p8qbxi57 36 13 , , , cord-326673-p8qbxi57 36 14 3.6 3.6 CD cord-326673-p8qbxi57 36 15 - - SYM cord-326673-p8qbxi57 36 16 6.4 6.4 CD cord-326673-p8qbxi57 36 17 days day NNS cord-326673-p8qbxi57 36 18 for for IN cord-326673-p8qbxi57 36 19 IgM IgM NNP cord-326673-p8qbxi57 36 20 and and CC cord-326673-p8qbxi57 36 21 6.6 6.6 CD cord-326673-p8qbxi57 36 22 - - SYM cord-326673-p8qbxi57 36 23 22 22 CD cord-326673-p8qbxi57 36 24 days day NNS cord-326673-p8qbxi57 36 25 for for IN cord-326673-p8qbxi57 36 26 IgG IgG NNP cord-326673-p8qbxi57 36 27 ( ( -LRB- cord-326673-p8qbxi57 36 28 Curtis Curtis NNP cord-326673-p8qbxi57 36 29 & & CC cord-326673-p8qbxi57 36 30 Bourne Bourne NNP cord-326673-p8qbxi57 36 31 , , , cord-326673-p8qbxi57 36 32 1973 1973 CD cord-326673-p8qbxi57 36 33 ) ) -RRB- cord-326673-p8qbxi57 36 34 . . . cord-326673-p8qbxi57 37 1 Variability variability NN cord-326673-p8qbxi57 37 2 in in IN cord-326673-p8qbxi57 37 3 these these DT cord-326673-p8qbxi57 37 4 results result NNS cord-326673-p8qbxi57 37 5 is be VBZ cord-326673-p8qbxi57 37 6 due due JJ cord-326673-p8qbxi57 37 7 to to IN cord-326673-p8qbxi57 37 8 the the DT cord-326673-p8qbxi57 37 9 range range NN cord-326673-p8qbxi57 37 10 of of IN cord-326673-p8qbxi57 37 11 methods method NNS cord-326673-p8qbxi57 37 12 used use VBN cord-326673-p8qbxi57 37 13 for for IN cord-326673-p8qbxi57 37 14 naeasurement naeasurement NNP cord-326673-p8qbxi57 37 15 , , , cord-326673-p8qbxi57 37 16 and and CC cord-326673-p8qbxi57 37 17 whether whether IN cord-326673-p8qbxi57 37 18 allowance allowance NN cord-326673-p8qbxi57 37 19 has have VBZ cord-326673-p8qbxi57 37 20 been be VBN cord-326673-p8qbxi57 37 21 made make VBN cord-326673-p8qbxi57 37 22 for for IN cord-326673-p8qbxi57 37 23 the the DT cord-326673-p8qbxi57 37 24 production production NN cord-326673-p8qbxi57 37 25 of of IN cord-326673-p8qbxi57 37 26 antibody antibody NN cord-326673-p8qbxi57 37 27 by by IN cord-326673-p8qbxi57 37 28 the the DT cord-326673-p8qbxi57 37 29 neonatal neonatal JJ cord-326673-p8qbxi57 37 30 immune immune JJ cord-326673-p8qbxi57 37 31 system system NN cord-326673-p8qbxi57 37 32 and and CC cord-326673-p8qbxi57 37 33 the the DT cord-326673-p8qbxi57 37 34 dilution dilution NN cord-326673-p8qbxi57 37 35 effect effect NN cord-326673-p8qbxi57 37 36 of of IN cord-326673-p8qbxi57 37 37 increasing increase VBG cord-326673-p8qbxi57 37 38 blood blood NN cord-326673-p8qbxi57 37 39 volume volume NN cord-326673-p8qbxi57 37 40 during during IN cord-326673-p8qbxi57 37 41 growth growth NN cord-326673-p8qbxi57 37 42 . . . cord-326673-p8qbxi57 38 1 Indeed indeed RB cord-326673-p8qbxi57 38 2 , , , cord-326673-p8qbxi57 38 3 Francis Francis NNP cord-326673-p8qbxi57 38 4 and and CC cord-326673-p8qbxi57 38 5 Black Black NNP cord-326673-p8qbxi57 38 6 ( ( -LRB- cord-326673-p8qbxi57 38 7 1984 1984 CD cord-326673-p8qbxi57 38 8 ) ) -RRB- cord-326673-p8qbxi57 38 9 concluded conclude VBD cord-326673-p8qbxi57 38 10 that that IN cord-326673-p8qbxi57 38 11 the the DT cord-326673-p8qbxi57 38 12 decay decay NN cord-326673-p8qbxi57 38 13 of of IN cord-326673-p8qbxi57 38 14 serum serum NN cord-326673-p8qbxi57 38 15 neutralizing neutralize VBG cord-326673-p8qbxi57 38 16 IgG IgG NNP cord-326673-p8qbxi57 38 17 titres titre NNS cord-326673-p8qbxi57 38 18 during during IN cord-326673-p8qbxi57 38 19 the the DT cord-326673-p8qbxi57 38 20 first first JJ cord-326673-p8qbxi57 38 21 70 70 CD cord-326673-p8qbxi57 38 22 days day NNS cord-326673-p8qbxi57 38 23 of of IN cord-326673-p8qbxi57 38 24 life life NN cord-326673-p8qbxi57 38 25 in in IN cord-326673-p8qbxi57 38 26 the the DT cord-326673-p8qbxi57 38 27 pig pig NN cord-326673-p8qbxi57 38 28 was be VBD cord-326673-p8qbxi57 38 29 largely largely RB cord-326673-p8qbxi57 38 30 a a DT cord-326673-p8qbxi57 38 31 result result NN cord-326673-p8qbxi57 38 32 of of IN cord-326673-p8qbxi57 38 33 expanding expand VBG cord-326673-p8qbxi57 38 34 blood blood NN cord-326673-p8qbxi57 38 35 volume volume NN cord-326673-p8qbxi57 38 36 and and CC cord-326673-p8qbxi57 38 37 not not RB cord-326673-p8qbxi57 38 38 catabolism catabolism NN cord-326673-p8qbxi57 38 39 of of IN cord-326673-p8qbxi57 38 40 the the DT cord-326673-p8qbxi57 38 41 antibody antibody NN cord-326673-p8qbxi57 38 42 . . . cord-326673-p8qbxi57 39 1 There there EX cord-326673-p8qbxi57 39 2 is be VBZ cord-326673-p8qbxi57 39 3 ample ample JJ cord-326673-p8qbxi57 39 4 evidence evidence NN cord-326673-p8qbxi57 39 5 that that IN cord-326673-p8qbxi57 39 6 in in IN cord-326673-p8qbxi57 39 7 addition addition NN cord-326673-p8qbxi57 39 8 to to IN cord-326673-p8qbxi57 39 9 the the DT cord-326673-p8qbxi57 39 10 protective protective JJ cord-326673-p8qbxi57 39 11 potential potential NN cord-326673-p8qbxi57 39 12 of of IN cord-326673-p8qbxi57 39 13 MDA MDA NNP cord-326673-p8qbxi57 39 14 , , , cord-326673-p8qbxi57 39 15 it -PRON- PRP cord-326673-p8qbxi57 39 16 is be VBZ cord-326673-p8qbxi57 39 17 also also RB cord-326673-p8qbxi57 39 18 responsible responsible JJ cord-326673-p8qbxi57 39 19 for for IN cord-326673-p8qbxi57 39 20 marked marked JJ cord-326673-p8qbxi57 39 21 antigen antigen NN cord-326673-p8qbxi57 39 22 - - HYPH cord-326673-p8qbxi57 39 23 specific specific JJ cord-326673-p8qbxi57 39 24 immunosuppression immunosuppression NN cord-326673-p8qbxi57 39 25 in in IN cord-326673-p8qbxi57 39 26 young young JJ cord-326673-p8qbxi57 39 27 ani ani NNP cord-326673-p8qbxi57 39 28 - - HYPH cord-326673-p8qbxi57 39 29 mals mal NNS cord-326673-p8qbxi57 39 30 for for IN cord-326673-p8qbxi57 39 31 periods period NNS cord-326673-p8qbxi57 39 32 that that WDT cord-326673-p8qbxi57 39 33 exceed exceed VBP cord-326673-p8qbxi57 39 34 the the DT cord-326673-p8qbxi57 39 35 period period NN cord-326673-p8qbxi57 39 36 of of IN cord-326673-p8qbxi57 39 37 protection protection NN cord-326673-p8qbxi57 39 38 ( ( -LRB- cord-326673-p8qbxi57 39 39 Francis Francis NNP cord-326673-p8qbxi57 39 40 & & CC cord-326673-p8qbxi57 39 41 Black Black NNP cord-326673-p8qbxi57 39 42 , , , cord-326673-p8qbxi57 39 43 1986 1986 CD cord-326673-p8qbxi57 39 44 ) ) -RRB- cord-326673-p8qbxi57 39 45 . . . cord-326673-p8qbxi57 40 1 This this DT cord-326673-p8qbxi57 40 2 is be VBZ cord-326673-p8qbxi57 40 3 demonstrated demonstrate VBN cord-326673-p8qbxi57 40 4 in in IN cord-326673-p8qbxi57 40 5 vivo vivo NN cord-326673-p8qbxi57 40 6 by by IN cord-326673-p8qbxi57 40 7 interference interference NN cord-326673-p8qbxi57 40 8 with with IN cord-326673-p8qbxi57 40 9 the the DT cord-326673-p8qbxi57 40 10 serum serum NN cord-326673-p8qbxi57 40 11 antibody antibody NN cord-326673-p8qbxi57 40 12 response response NN cord-326673-p8qbxi57 40 13 to to IN cord-326673-p8qbxi57 40 14 vaccination vaccination NN cord-326673-p8qbxi57 40 15 , , , cord-326673-p8qbxi57 40 16 and and CC cord-326673-p8qbxi57 40 17 in in IN cord-326673-p8qbxi57 40 18 vitro vitro FW cord-326673-p8qbxi57 40 19 by by IN cord-326673-p8qbxi57 40 20 a a DT cord-326673-p8qbxi57 40 21 reduction reduction NN cord-326673-p8qbxi57 40 22 in in IN cord-326673-p8qbxi57 40 23 the the DT cord-326673-p8qbxi57 40 24 reactivity reactivity NN cord-326673-p8qbxi57 40 25 of of IN cord-326673-p8qbxi57 40 26 lymphocytes lymphocyte NNS cord-326673-p8qbxi57 40 27 upon upon IN cord-326673-p8qbxi57 40 28 stimulation stimulation NN cord-326673-p8qbxi57 40 29 with with IN cord-326673-p8qbxi57 40 30 antigen antigen NN cord-326673-p8qbxi57 40 31 . . . cord-326673-p8qbxi57 41 1 In in IN cord-326673-p8qbxi57 41 2 this this DT cord-326673-p8qbxi57 41 3 way way NN cord-326673-p8qbxi57 41 4 MDA MDA NNP cord-326673-p8qbxi57 41 5 may may MD cord-326673-p8qbxi57 41 6 interfere interfere VB cord-326673-p8qbxi57 41 7 with with IN cord-326673-p8qbxi57 41 8 the the DT cord-326673-p8qbxi57 41 9 active active JJ cord-326673-p8qbxi57 41 10 immunization immunization NN cord-326673-p8qbxi57 41 11 of of IN cord-326673-p8qbxi57 41 12 young young JJ cord-326673-p8qbxi57 41 13 animals animal NNS cord-326673-p8qbxi57 41 14 in in IN cord-326673-p8qbxi57 41 15 a a DT cord-326673-p8qbxi57 41 16 reversible reversible JJ cord-326673-p8qbxi57 41 17 fashion fashion NN cord-326673-p8qbxi57 41 18 . . . cord-326673-p8qbxi57 42 1 In in IN cord-326673-p8qbxi57 42 2 cattle cattle NNS cord-326673-p8qbxi57 42 3 and and CC cord-326673-p8qbxi57 42 4 pigs pig NNS cord-326673-p8qbxi57 42 5 , , , cord-326673-p8qbxi57 42 6 this this DT cord-326673-p8qbxi57 42 7 phenomenon phenomenon NN cord-326673-p8qbxi57 42 8 has have VBZ cord-326673-p8qbxi57 42 9 been be VBN cord-326673-p8qbxi57 42 10 demonstrated demonstrate VBN cord-326673-p8qbxi57 42 11 for for IN cord-326673-p8qbxi57 42 12 several several JJ cord-326673-p8qbxi57 42 13 infectious infectious JJ cord-326673-p8qbxi57 42 14 diseases disease NNS cord-326673-p8qbxi57 42 15 including include VBG cord-326673-p8qbxi57 42 16 FMD FMD NNP cord-326673-p8qbxi57 42 17 . . . cord-326673-p8qbxi57 43 1 It -PRON- PRP cord-326673-p8qbxi57 43 2 has have VBZ cord-326673-p8qbxi57 43 3 long long RB cord-326673-p8qbxi57 43 4 been be VBN cord-326673-p8qbxi57 43 5 appreciated appreciate VBN cord-326673-p8qbxi57 43 6 that that IN cord-326673-p8qbxi57 43 7 the the DT cord-326673-p8qbxi57 43 8 active active JJ cord-326673-p8qbxi57 43 9 immunization immunization NN cord-326673-p8qbxi57 43 10 of of IN cord-326673-p8qbxi57 43 11 vertebrates vertebrate NNS cord-326673-p8qbxi57 43 12 early early RB cord-326673-p8qbxi57 43 13 in in IN cord-326673-p8qbxi57 43 14 life life NN cord-326673-p8qbxi57 43 15 is be VBZ cord-326673-p8qbxi57 43 16 not not RB cord-326673-p8qbxi57 43 17 as as RB cord-326673-p8qbxi57 43 18 effective effective JJ cord-326673-p8qbxi57 43 19 as as IN cord-326673-p8qbxi57 43 20 in in IN cord-326673-p8qbxi57 43 21 the the DT cord-326673-p8qbxi57 43 22 mature mature JJ cord-326673-p8qbxi57 43 23 individual individual NN cord-326673-p8qbxi57 43 24 . . . cord-326673-p8qbxi57 44 1 Immaturity immaturity NN cord-326673-p8qbxi57 44 2 of of IN cord-326673-p8qbxi57 44 3 the the DT cord-326673-p8qbxi57 44 4 immune immune JJ cord-326673-p8qbxi57 44 5 system system NN cord-326673-p8qbxi57 44 6 at at IN cord-326673-p8qbxi57 44 7 birth birth NN cord-326673-p8qbxi57 44 8 is be VBZ cord-326673-p8qbxi57 44 9 partly partly RB cord-326673-p8qbxi57 44 10 responsible responsible JJ cord-326673-p8qbxi57 44 11 for for IN cord-326673-p8qbxi57 44 12 this this DT cord-326673-p8qbxi57 44 13 observation observation NN cord-326673-p8qbxi57 44 14 , , , cord-326673-p8qbxi57 44 15 although although IN cord-326673-p8qbxi57 44 16 it -PRON- PRP cord-326673-p8qbxi57 44 17 has have VBZ cord-326673-p8qbxi57 44 18 been be VBN cord-326673-p8qbxi57 44 19 shown show VBN cord-326673-p8qbxi57 44 20 in in IN cord-326673-p8qbxi57 44 21 the the DT cord-326673-p8qbxi57 44 22 domesticated domesticate VBN cord-326673-p8qbxi57 44 23 species specie NNS cord-326673-p8qbxi57 44 24 that that WDT cord-326673-p8qbxi57 44 25 good good JJ cord-326673-p8qbxi57 44 26 vaccination vaccination NN cord-326673-p8qbxi57 44 27 responses response NNS cord-326673-p8qbxi57 44 28 can can MD cord-326673-p8qbxi57 44 29 be be VB cord-326673-p8qbxi57 44 30 generated generate VBN cord-326673-p8qbxi57 44 31 from from IN cord-326673-p8qbxi57 44 32 the the DT cord-326673-p8qbxi57 44 33 2nd 2nd JJ cord-326673-p8qbxi57 44 34 week week NN cord-326673-p8qbxi57 44 35 of of IN cord-326673-p8qbxi57 44 36 life life NN cord-326673-p8qbxi57 44 37 ( ( -LRB- cord-326673-p8qbxi57 44 38 Ahl Ahl NNP cord-326673-p8qbxi57 44 39 & & CC cord-326673-p8qbxi57 44 40 Wittman Wittman NNP cord-326673-p8qbxi57 44 41 , , , cord-326673-p8qbxi57 44 42 1987 1987 CD cord-326673-p8qbxi57 44 43 ) ) -RRB- cord-326673-p8qbxi57 44 44 . . . cord-326673-p8qbxi57 45 1 The the DT cord-326673-p8qbxi57 45 2 greatest great JJS cord-326673-p8qbxi57 45 3 suppressive suppressive JJ cord-326673-p8qbxi57 45 4 influence influence NN cord-326673-p8qbxi57 45 5 on on IN cord-326673-p8qbxi57 45 6 vaccination vaccination NN cord-326673-p8qbxi57 45 7 response response NN cord-326673-p8qbxi57 45 8 in in IN cord-326673-p8qbxi57 45 9 the the DT cord-326673-p8qbxi57 45 10 neonate neonate NN cord-326673-p8qbxi57 45 11 is be VBZ cord-326673-p8qbxi57 45 12 MDA MDA NNP cord-326673-p8qbxi57 45 13 . . . cord-326673-p8qbxi57 46 1 Immediately immediately RB cord-326673-p8qbxi57 46 2 after after IN cord-326673-p8qbxi57 46 3 birth birth NN cord-326673-p8qbxi57 46 4 , , , cord-326673-p8qbxi57 46 5 there there EX cord-326673-p8qbxi57 46 6 is be VBZ cord-326673-p8qbxi57 46 7 a a DT cord-326673-p8qbxi57 46 8 short short JJ cord-326673-p8qbxi57 46 9 period period NN cord-326673-p8qbxi57 46 10 of of IN cord-326673-p8qbxi57 46 11 generalized generalized JJ cord-326673-p8qbxi57 46 12 suppression suppression NN cord-326673-p8qbxi57 46 13 of of IN cord-326673-p8qbxi57 46 14 B B NNP cord-326673-p8qbxi57 46 15 and and CC cord-326673-p8qbxi57 46 16 T T NNP cord-326673-p8qbxi57 46 17 lymphocyte lymphocyte NN cord-326673-p8qbxi57 46 18 responsiveness responsiveness NN cord-326673-p8qbxi57 46 19 , , , cord-326673-p8qbxi57 46 20 which which WDT cord-326673-p8qbxi57 46 21 could could MD cord-326673-p8qbxi57 46 22 be be VB cord-326673-p8qbxi57 46 23 due due JJ cord-326673-p8qbxi57 46 24 to to IN cord-326673-p8qbxi57 46 25 the the DT cord-326673-p8qbxi57 46 26 transfer transfer NN cord-326673-p8qbxi57 46 27 of of IN cord-326673-p8qbxi57 46 28 immunosuppressive immunosuppressive JJ cord-326673-p8qbxi57 46 29 factors factor NNS cord-326673-p8qbxi57 46 30 in in IN cord-326673-p8qbxi57 46 31 colostrum colostrum NN cord-326673-p8qbxi57 46 32 such such JJ cord-326673-p8qbxi57 46 33 as as IN cord-326673-p8qbxi57 46 34 cortisol cortisol NN cord-326673-p8qbxi57 46 35 , , , cord-326673-p8qbxi57 46 36 histamine histamine NN cord-326673-p8qbxi57 46 37 and and CC cord-326673-p8qbxi57 46 38 cytokines cytokine NNS cord-326673-p8qbxi57 46 39 ( ( -LRB- cord-326673-p8qbxi57 46 40 Clover Clover NNP cord-326673-p8qbxi57 46 41 & & CC cord-326673-p8qbxi57 46 42 Zarkower Zarkower NNP cord-326673-p8qbxi57 46 43 , , , cord-326673-p8qbxi57 46 44 1980 1980 CD cord-326673-p8qbxi57 46 45 ) ) -RRB- cord-326673-p8qbxi57 46 46 . . . cord-326673-p8qbxi57 47 1 However however RB cord-326673-p8qbxi57 47 2 , , , cord-326673-p8qbxi57 47 3 it -PRON- PRP cord-326673-p8qbxi57 47 4 has have VBZ cord-326673-p8qbxi57 47 5 been be VBN cord-326673-p8qbxi57 47 6 clearly clearly RB cord-326673-p8qbxi57 47 7 shown show VBN cord-326673-p8qbxi57 47 8 that that IN cord-326673-p8qbxi57 47 9 the the DT cord-326673-p8qbxi57 47 10 presence presence NN cord-326673-p8qbxi57 47 11 of of IN cord-326673-p8qbxi57 47 12 MDA MDA NNP cord-326673-p8qbxi57 47 13 in in IN cord-326673-p8qbxi57 47 14 the the DT cord-326673-p8qbxi57 47 15 offspring offspring NN cord-326673-p8qbxi57 47 16 correlates correlate VBZ cord-326673-p8qbxi57 47 17 with with IN cord-326673-p8qbxi57 47 18 the the DT cord-326673-p8qbxi57 47 19 antigen antigen NN cord-326673-p8qbxi57 47 20 - - HYPH cord-326673-p8qbxi57 47 21 specific specific JJ cord-326673-p8qbxi57 47 22 suppression suppression NN cord-326673-p8qbxi57 47 23 of of IN cord-326673-p8qbxi57 47 24 antibody antibody NN cord-326673-p8qbxi57 47 25 responses response NNS cord-326673-p8qbxi57 47 26 , , , cord-326673-p8qbxi57 47 27 an an DT cord-326673-p8qbxi57 47 28 effect effect NN cord-326673-p8qbxi57 47 29 that that WDT cord-326673-p8qbxi57 47 30 can can MD cord-326673-p8qbxi57 47 31 be be VB cord-326673-p8qbxi57 47 32 mimicked mimic VBN cord-326673-p8qbxi57 47 33 by by IN cord-326673-p8qbxi57 47 34 the the DT cord-326673-p8qbxi57 47 35 passive passive NNP cord-326673-p8qbxi57 47 36 administration administration NNP cord-326673-p8qbxi57 47 37 of of IN cord-326673-p8qbxi57 47 38 monoclonal monoclonal JJ cord-326673-p8qbxi57 47 39 antibodies antibody NNS cord-326673-p8qbxi57 47 40 to to IN cord-326673-p8qbxi57 47 41 neonatal neonatal JJ cord-326673-p8qbxi57 47 42 mice mouse NNS cord-326673-p8qbxi57 47 43 ( ( -LRB- cord-326673-p8qbxi57 47 44 Xiang Xiang NNP cord-326673-p8qbxi57 47 45 & & CC cord-326673-p8qbxi57 47 46 Ertl Ertl NNP cord-326673-p8qbxi57 47 47 , , , cord-326673-p8qbxi57 47 48 1992 1992 CD cord-326673-p8qbxi57 47 49 ) ) -RRB- cord-326673-p8qbxi57 47 50 . . . cord-326673-p8qbxi57 48 1 The the DT cord-326673-p8qbxi57 48 2 mechanism mechanism NN cord-326673-p8qbxi57 48 3 by by IN cord-326673-p8qbxi57 48 4 which which WDT cord-326673-p8qbxi57 48 5 MDA MDA NNP cord-326673-p8qbxi57 48 6 causes cause VBZ cord-326673-p8qbxi57 48 7 this this DT cord-326673-p8qbxi57 48 8 effect effect NN cord-326673-p8qbxi57 48 9 is be VBZ cord-326673-p8qbxi57 48 10 not not RB cord-326673-p8qbxi57 48 11 completely completely RB cord-326673-p8qbxi57 48 12 determined determined JJ cord-326673-p8qbxi57 48 13 for for IN cord-326673-p8qbxi57 48 14 any any DT cord-326673-p8qbxi57 48 15 species specie NNS cord-326673-p8qbxi57 48 16 . . . cord-326673-p8qbxi57 49 1 The the DT cord-326673-p8qbxi57 49 2 current current JJ cord-326673-p8qbxi57 49 3 hypotheses hypothesis NNS cord-326673-p8qbxi57 49 4 build build VBP cord-326673-p8qbxi57 49 5 upon upon IN cord-326673-p8qbxi57 49 6 the the DT cord-326673-p8qbxi57 49 7 proposed propose VBN cord-326673-p8qbxi57 49 8 mechanisms mechanism NNS cord-326673-p8qbxi57 49 9 for for IN cord-326673-p8qbxi57 49 10 regulation regulation NN cord-326673-p8qbxi57 49 11 of of IN cord-326673-p8qbxi57 49 12 the the DT cord-326673-p8qbxi57 49 13 immune immune JJ cord-326673-p8qbxi57 49 14 response response NN cord-326673-p8qbxi57 49 15 in in IN cord-326673-p8qbxi57 49 16 adults adult NNS cord-326673-p8qbxi57 49 17 . . . cord-326673-p8qbxi57 50 1 Initially initially RB cord-326673-p8qbxi57 50 2 it -PRON- PRP cord-326673-p8qbxi57 50 3 was be VBD cord-326673-p8qbxi57 50 4 thought think VBN cord-326673-p8qbxi57 50 5 that that IN cord-326673-p8qbxi57 50 6 MDA MDA NNP cord-326673-p8qbxi57 50 7 interfered interfere VBD cord-326673-p8qbxi57 50 8 with with IN cord-326673-p8qbxi57 50 9 the the DT cord-326673-p8qbxi57 50 10 generation generation NN cord-326673-p8qbxi57 50 11 of of IN cord-326673-p8qbxi57 50 12 an an DT cord-326673-p8qbxi57 50 13 antibody antibody NN cord-326673-p8qbxi57 50 14 response response NN cord-326673-p8qbxi57 50 15 following follow VBG cord-326673-p8qbxi57 50 16 vaccination vaccination NN cord-326673-p8qbxi57 50 17 of of IN cord-326673-p8qbxi57 50 18 young young JJ cord-326673-p8qbxi57 50 19 animals animal NNS cord-326673-p8qbxi57 50 20 purely purely RB cord-326673-p8qbxi57 50 21 by by IN cord-326673-p8qbxi57 50 22 the the DT cord-326673-p8qbxi57 50 23 enhanced enhance VBN cord-326673-p8qbxi57 50 24 removal removal NN cord-326673-p8qbxi57 50 25 of of IN cord-326673-p8qbxi57 50 26 inactivated inactivate VBN cord-326673-p8qbxi57 50 27 vaccine vaccine NN cord-326673-p8qbxi57 50 28 antigens antigen NNS cord-326673-p8qbxi57 50 29 or or CC cord-326673-p8qbxi57 50 30 by by IN cord-326673-p8qbxi57 50 31 neutralization neutralization NN cord-326673-p8qbxi57 50 32 of of IN cord-326673-p8qbxi57 50 33 attenuated attenuated JJ cord-326673-p8qbxi57 50 34 live live JJ cord-326673-p8qbxi57 50 35 vaccines vaccine NNS cord-326673-p8qbxi57 50 36 . . . cord-326673-p8qbxi57 51 1 In in IN cord-326673-p8qbxi57 51 2 both both DT cord-326673-p8qbxi57 51 3 instances instance NNS cord-326673-p8qbxi57 51 4 it -PRON- PRP cord-326673-p8qbxi57 51 5 was be VBD cord-326673-p8qbxi57 51 6 thought think VBN cord-326673-p8qbxi57 51 7 that that IN cord-326673-p8qbxi57 51 8 vaccine vaccine NN cord-326673-p8qbxi57 51 9 antigen antigen NN cord-326673-p8qbxi57 51 10 would would MD cord-326673-p8qbxi57 51 11 be be VB cord-326673-p8qbxi57 51 12 prevented prevent VBN cord-326673-p8qbxi57 51 13 from from IN cord-326673-p8qbxi57 51 14 encountering encounter VBG cord-326673-p8qbxi57 51 15 the the DT cord-326673-p8qbxi57 51 16 immunocompetent immunocompetent JJ cord-326673-p8qbxi57 51 17 cells cell NNS cord-326673-p8qbxi57 51 18 of of IN cord-326673-p8qbxi57 51 19 the the DT cord-326673-p8qbxi57 51 20 neonatal neonatal JJ cord-326673-p8qbxi57 51 21 immune immune JJ cord-326673-p8qbxi57 51 22 system system NN cord-326673-p8qbxi57 51 23 by by IN cord-326673-p8qbxi57 51 24 the the DT cord-326673-p8qbxi57 51 25 effective effective JJ cord-326673-p8qbxi57 51 26 ' ' `` cord-326673-p8qbxi57 51 27 antigen antigen NN cord-326673-p8qbxi57 51 28 blockade blockade NN cord-326673-p8qbxi57 51 29 ' ' '' cord-326673-p8qbxi57 51 30 provided provide VBN cord-326673-p8qbxi57 51 31 by by IN cord-326673-p8qbxi57 51 32 MDA MDA NNP cord-326673-p8qbxi57 51 33 to to IN cord-326673-p8qbxi57 51 34 the the DT cord-326673-p8qbxi57 51 35 specific specific JJ cord-326673-p8qbxi57 51 36 microorganism microorganism NN cord-326673-p8qbxi57 51 37 . . . cord-326673-p8qbxi57 52 1 More More JJR cord-326673-p8qbxi57 52 2 recent recent JJ cord-326673-p8qbxi57 52 3 evidence evidence NN cord-326673-p8qbxi57 52 4 suggests suggest VBZ cord-326673-p8qbxi57 52 5 that that IN cord-326673-p8qbxi57 52 6 MDA MDA NNP cord-326673-p8qbxi57 52 7 has have VBZ cord-326673-p8qbxi57 52 8 a a DT cord-326673-p8qbxi57 52 9 direct direct JJ cord-326673-p8qbxi57 52 10 suppressive suppressive JJ cord-326673-p8qbxi57 52 11 effect effect NN cord-326673-p8qbxi57 52 12 upon upon IN cord-326673-p8qbxi57 52 13 immunocompetent immunocompetent JJ cord-326673-p8qbxi57 52 14 cells cell NNS cord-326673-p8qbxi57 52 15 via via IN cord-326673-p8qbxi57 52 16 a a DT cord-326673-p8qbxi57 52 17 similar similar JJ cord-326673-p8qbxi57 52 18 negative negative JJ cord-326673-p8qbxi57 52 19 feedback feedback NN cord-326673-p8qbxi57 52 20 system system NN cord-326673-p8qbxi57 52 21 to to IN cord-326673-p8qbxi57 52 22 the the DT cord-326673-p8qbxi57 52 23 one one NN cord-326673-p8qbxi57 52 24 that that WDT cord-326673-p8qbxi57 52 25 is be VBZ cord-326673-p8qbxi57 52 26 thought think VBN cord-326673-p8qbxi57 52 27 to to TO cord-326673-p8qbxi57 52 28 regulate regulate VB cord-326673-p8qbxi57 52 29 the the DT cord-326673-p8qbxi57 52 30 antibody antibody NN cord-326673-p8qbxi57 52 31 response response NN cord-326673-p8qbxi57 52 32 in in IN cord-326673-p8qbxi57 52 33 mature mature JJ cord-326673-p8qbxi57 52 34 animals animal NNS cord-326673-p8qbxi57 52 35 ( ( -LRB- cord-326673-p8qbxi57 52 36 Katz Katz NNP cord-326673-p8qbxi57 52 37 , , , cord-326673-p8qbxi57 52 38 1980 1980 CD cord-326673-p8qbxi57 52 39 ) ) -RRB- cord-326673-p8qbxi57 52 40 . . . cord-326673-p8qbxi57 53 1 By by IN cord-326673-p8qbxi57 53 2 the the DT cord-326673-p8qbxi57 53 3 cross cross NN cord-326673-p8qbxi57 53 4 - - JJ cord-326673-p8qbxi57 53 5 linking linking NN cord-326673-p8qbxi57 53 6 of of IN cord-326673-p8qbxi57 53 7 membrane membrane NN cord-326673-p8qbxi57 53 8 - - HYPH cord-326673-p8qbxi57 53 9 bound bind VBN cord-326673-p8qbxi57 53 10 immunoglobulin immunoglobulin NN cord-326673-p8qbxi57 53 11 Fc Fc NNP cord-326673-p8qbxi57 53 12 - - HYPH cord-326673-p8qbxi57 53 13 receptors receptor NNS cord-326673-p8qbxi57 53 14 with with IN cord-326673-p8qbxi57 53 15 surface surface NN cord-326673-p8qbxi57 53 16 immunoglobulin immunoglobulin NN cord-326673-p8qbxi57 53 17 , , , cord-326673-p8qbxi57 53 18 immune immune JJ cord-326673-p8qbxi57 53 19 complexes complex NNS cord-326673-p8qbxi57 53 20 comprised comprise VBN cord-326673-p8qbxi57 53 21 of of IN cord-326673-p8qbxi57 53 22 MDA MDA NNP cord-326673-p8qbxi57 53 23 and and CC cord-326673-p8qbxi57 53 24 vaccinal vaccinal NNP cord-326673-p8qbxi57 53 25 antigen antigen NN cord-326673-p8qbxi57 53 26 may may MD cord-326673-p8qbxi57 53 27 deliver deliver VB cord-326673-p8qbxi57 53 28 a a DT cord-326673-p8qbxi57 53 29 negative negative JJ cord-326673-p8qbxi57 53 30 signal signal NN cord-326673-p8qbxi57 53 31 to to IN cord-326673-p8qbxi57 53 32 the the DT cord-326673-p8qbxi57 53 33 B b NN cord-326673-p8qbxi57 53 34 cell cell NN cord-326673-p8qbxi57 53 35 . . . cord-326673-p8qbxi57 54 1 This this DT cord-326673-p8qbxi57 54 2 suppressive suppressive JJ cord-326673-p8qbxi57 54 3 signal signal NN cord-326673-p8qbxi57 54 4 is be VBZ cord-326673-p8qbxi57 54 5 antigenspecific antigenspecific JJ cord-326673-p8qbxi57 54 6 and and CC cord-326673-p8qbxi57 54 7 has have VBZ cord-326673-p8qbxi57 54 8 the the DT cord-326673-p8qbxi57 54 9 potential potential NN cord-326673-p8qbxi57 54 10 to to TO cord-326673-p8qbxi57 54 11 be be VB cord-326673-p8qbxi57 54 12 limited limit VBN cord-326673-p8qbxi57 54 13 to to IN cord-326673-p8qbxi57 54 14 particular particular JJ cord-326673-p8qbxi57 54 15 MDA MDA NNP cord-326673-p8qbxi57 54 16 isotypes isotypes NNP cord-326673-p8qbxi57 54 17 ( ( -LRB- cord-326673-p8qbxi57 54 18 Uhr Uhr NNP cord-326673-p8qbxi57 54 19 & & CC cord-326673-p8qbxi57 54 20 Mohler Mohler NNP cord-326673-p8qbxi57 54 21 , , , cord-326673-p8qbxi57 54 22 1968 1968 CD cord-326673-p8qbxi57 54 23 ) ) -RRB- cord-326673-p8qbxi57 54 24 . . . cord-326673-p8qbxi57 55 1 MDA MDA NNP cord-326673-p8qbxi57 55 2 could could MD cord-326673-p8qbxi57 55 3 thus thus RB cord-326673-p8qbxi57 55 4 act act VB cord-326673-p8qbxi57 55 5 directly directly RB cord-326673-p8qbxi57 55 6 on on IN cord-326673-p8qbxi57 55 7 B b NN cord-326673-p8qbxi57 55 8 lymphocytes lymphocyte NNS cord-326673-p8qbxi57 55 9 to to IN cord-326673-p8qbxi57 55 10 down down RB cord-326673-p8qbxi57 55 11 - - HYPH cord-326673-p8qbxi57 55 12 regulate regulate VB cord-326673-p8qbxi57 55 13 the the DT cord-326673-p8qbxi57 55 14 proliferation proliferation NN cord-326673-p8qbxi57 55 15 and and CC cord-326673-p8qbxi57 55 16 differentiation differentiation NN cord-326673-p8qbxi57 55 17 required require VBN cord-326673-p8qbxi57 55 18 for for IN cord-326673-p8qbxi57 55 19 antibody antibody NN cord-326673-p8qbxi57 55 20 production production NN cord-326673-p8qbxi57 55 21 . . . cord-326673-p8qbxi57 56 1 Alternatively alternatively RB cord-326673-p8qbxi57 56 2 MDA MDA NNP cord-326673-p8qbxi57 56 3 complexed complexed JJ cord-326673-p8qbxi57 56 4 with with IN cord-326673-p8qbxi57 56 5 vaccinal vaccinal JJ cord-326673-p8qbxi57 56 6 antigen antigen NNP cord-326673-p8qbxi57 56 7 may may MD cord-326673-p8qbxi57 56 8 act act VB cord-326673-p8qbxi57 56 9 through through IN cord-326673-p8qbxi57 56 10 a a DT cord-326673-p8qbxi57 56 11 regulatory regulatory JJ cord-326673-p8qbxi57 56 12 network network NN cord-326673-p8qbxi57 56 13 to to TO cord-326673-p8qbxi57 56 14 either either CC cord-326673-p8qbxi57 56 15 suppress suppress VB cord-326673-p8qbxi57 56 16 antigen antigen NN cord-326673-p8qbxi57 56 17 - - HYPH cord-326673-p8qbxi57 56 18 specific specific JJ cord-326673-p8qbxi57 56 19 TH TH NNP cord-326673-p8qbxi57 56 20 cells cell NNS cord-326673-p8qbxi57 56 21 or or CC cord-326673-p8qbxi57 56 22 actively actively RB cord-326673-p8qbxi57 56 23 up up RB cord-326673-p8qbxi57 56 24 - - : cord-326673-p8qbxi57 56 25 regulate regulate VB cord-326673-p8qbxi57 56 26 the the DT cord-326673-p8qbxi57 56 27 production production NN cord-326673-p8qbxi57 56 28 of of IN cord-326673-p8qbxi57 56 29 an an DT cord-326673-p8qbxi57 56 30 antigen antigen NN cord-326673-p8qbxi57 56 31 - - HYPH cord-326673-p8qbxi57 56 32 specific specific JJ cord-326673-p8qbxi57 56 33 T t NN cord-326673-p8qbxi57 56 34 suppressor suppressor NN cord-326673-p8qbxi57 56 35 cell cell NN cord-326673-p8qbxi57 56 36 population population NN cord-326673-p8qbxi57 56 37 ( ( -LRB- cord-326673-p8qbxi57 56 38 Harte Harte NNP cord-326673-p8qbxi57 56 39 & & CC cord-326673-p8qbxi57 56 40 Playfair Playfair NNP cord-326673-p8qbxi57 56 41 , , , cord-326673-p8qbxi57 56 42 1983 1983 CD cord-326673-p8qbxi57 56 43 ) ) -RRB- cord-326673-p8qbxi57 56 44 . . . cord-326673-p8qbxi57 57 1 A a DT cord-326673-p8qbxi57 57 2 third third JJ cord-326673-p8qbxi57 57 3 theoly theoly NN cord-326673-p8qbxi57 57 4 of of IN cord-326673-p8qbxi57 57 5 MDA MDA NNP cord-326673-p8qbxi57 57 6 - - HYPH cord-326673-p8qbxi57 57 7 related relate VBN cord-326673-p8qbxi57 57 8 immunosuppression immunosuppression NN cord-326673-p8qbxi57 57 9 makes make VBZ cord-326673-p8qbxi57 57 10 use use NN cord-326673-p8qbxi57 57 11 of of IN cord-326673-p8qbxi57 57 12 the the DT cord-326673-p8qbxi57 57 13 ' ' `` cord-326673-p8qbxi57 57 14 idiotype idiotype NNP cord-326673-p8qbxi57 57 15 - - HYPH cord-326673-p8qbxi57 57 16 anti anti NN cord-326673-p8qbxi57 57 17 - - JJ cord-326673-p8qbxi57 57 18 idiotype idiotype JJ cord-326673-p8qbxi57 57 19 ' ' POS cord-326673-p8qbxi57 57 20 immunoregulatory immunoregulatory NNP cord-326673-p8qbxi57 57 21 network network NN cord-326673-p8qbxi57 57 22 proposed propose VBN cord-326673-p8qbxi57 57 23 by by IN cord-326673-p8qbxi57 57 24 Jerne Jerne NNP cord-326673-p8qbxi57 57 25 ( ( -LRB- cord-326673-p8qbxi57 57 26 1974 1974 CD cord-326673-p8qbxi57 57 27 ) ) -RRB- cord-326673-p8qbxi57 57 28 . . . cord-326673-p8qbxi57 58 1 In in IN cord-326673-p8qbxi57 58 2 this this DT cord-326673-p8qbxi57 58 3 antigen antigen NN cord-326673-p8qbxi57 58 4 - - HYPH cord-326673-p8qbxi57 58 5 free free JJ cord-326673-p8qbxi57 58 6 system system NN cord-326673-p8qbxi57 58 7 MDA MDA NNP cord-326673-p8qbxi57 58 8 would would MD cord-326673-p8qbxi57 58 9 induce induce VB cord-326673-p8qbxi57 58 10 antibody antibody NN cord-326673-p8qbxi57 58 11 in in IN cord-326673-p8qbxi57 58 12 the the DT cord-326673-p8qbxi57 58 13 offspring offspring NN cord-326673-p8qbxi57 58 14 which which WDT cord-326673-p8qbxi57 58 15 recognized recognize VBD cord-326673-p8qbxi57 58 16 its -PRON- PRP$ cord-326673-p8qbxi57 58 17 own own JJ cord-326673-p8qbxi57 58 18 antigen antigen NN cord-326673-p8qbxi57 58 19 - - HYPH cord-326673-p8qbxi57 58 20 binding bind VBG cord-326673-p8qbxi57 58 21 site site NN cord-326673-p8qbxi57 58 22 , , , cord-326673-p8qbxi57 58 23 or or CC cord-326673-p8qbxi57 58 24 idiotype idiotype NN cord-326673-p8qbxi57 58 25 . . . cord-326673-p8qbxi57 59 1 The the DT cord-326673-p8qbxi57 59 2 internal internal JJ cord-326673-p8qbxi57 59 3 image image NN cord-326673-p8qbxi57 59 4 antibody antibody NN cord-326673-p8qbxi57 59 5 molecules molecule NNS cord-326673-p8qbxi57 59 6 , , , cord-326673-p8qbxi57 59 7 or or CC cord-326673-p8qbxi57 59 8 anti anti NNS cord-326673-p8qbxi57 59 9 - - NNS cord-326673-p8qbxi57 59 10 idiotypes idiotype NNS cord-326673-p8qbxi57 59 11 , , , cord-326673-p8qbxi57 59 12 thus thus RB cord-326673-p8qbxi57 59 13 created create VBN cord-326673-p8qbxi57 59 14 could could MD cord-326673-p8qbxi57 59 15 then then RB cord-326673-p8qbxi57 59 16 interact interact VB cord-326673-p8qbxi57 59 17 with with IN cord-326673-p8qbxi57 59 18 antigen antigen NN cord-326673-p8qbxi57 59 19 receptors receptor NNS cord-326673-p8qbxi57 59 20 on on IN cord-326673-p8qbxi57 59 21 the the DT cord-326673-p8qbxi57 59 22 surface surface NN cord-326673-p8qbxi57 59 23 of of IN cord-326673-p8qbxi57 59 24 B b NN cord-326673-p8qbxi57 59 25 and and CC cord-326673-p8qbxi57 59 26 T t NN cord-326673-p8qbxi57 59 27 lymphocytes lymphocyte NNS cord-326673-p8qbxi57 59 28 due due JJ cord-326673-p8qbxi57 59 29 to to IN cord-326673-p8qbxi57 59 30 their -PRON- PRP$ cord-326673-p8qbxi57 59 31 similarity similarity NN cord-326673-p8qbxi57 59 32 to to IN cord-326673-p8qbxi57 59 33 the the DT cord-326673-p8qbxi57 59 34 initiating initiate VBG cord-326673-p8qbxi57 59 35 antigen antigen NN cord-326673-p8qbxi57 59 36 . . . cord-326673-p8qbxi57 60 1 This this DT cord-326673-p8qbxi57 60 2 leaves leave VBZ cord-326673-p8qbxi57 60 3 the the DT cord-326673-p8qbxi57 60 4 Fc Fc NNP cord-326673-p8qbxi57 60 5 portion portion NN cord-326673-p8qbxi57 60 6 of of IN cord-326673-p8qbxi57 60 7 the the DT cord-326673-p8qbxi57 60 8 antibody antibody NN cord-326673-p8qbxi57 60 9 molecule molecule NN cord-326673-p8qbxi57 60 10 free free JJ cord-326673-p8qbxi57 60 11 to to TO cord-326673-p8qbxi57 60 12 deliver deliver VB cord-326673-p8qbxi57 60 13 a a DT cord-326673-p8qbxi57 60 14 negative negative JJ cord-326673-p8qbxi57 60 15 signal signal NN cord-326673-p8qbxi57 60 16 to to IN cord-326673-p8qbxi57 60 17 the the DT cord-326673-p8qbxi57 60 18 cell cell NN cord-326673-p8qbxi57 60 19 through through IN cord-326673-p8qbxi57 60 20 the the DT cord-326673-p8qbxi57 60 21 Fc Fc NNP cord-326673-p8qbxi57 60 22 receptors receptor NNS cord-326673-p8qbxi57 60 23 . . . cord-326673-p8qbxi57 61 1 In in IN cord-326673-p8qbxi57 61 2 reality reality NN cord-326673-p8qbxi57 61 3 the the DT cord-326673-p8qbxi57 61 4 results result NNS cord-326673-p8qbxi57 61 5 of of IN cord-326673-p8qbxi57 61 6 vaccination vaccination NN cord-326673-p8qbxi57 61 7 trials trial NNS cord-326673-p8qbxi57 61 8 in in IN cord-326673-p8qbxi57 61 9 young young JJ cord-326673-p8qbxi57 61 10 animals animal NNS cord-326673-p8qbxi57 61 11 do do VBP cord-326673-p8qbxi57 61 12 not not RB cord-326673-p8qbxi57 61 13 decisively decisively RB cord-326673-p8qbxi57 61 14 confirm confirm VB cord-326673-p8qbxi57 61 15 or or CC cord-326673-p8qbxi57 61 16 refute refute VB cord-326673-p8qbxi57 61 17 any any DT cord-326673-p8qbxi57 61 18 one one CD cord-326673-p8qbxi57 61 19 of of IN cord-326673-p8qbxi57 61 20 these these DT cord-326673-p8qbxi57 61 21 theories theory NNS cord-326673-p8qbxi57 61 22 . . . cord-326673-p8qbxi57 62 1 Suppression suppression NN cord-326673-p8qbxi57 62 2 of of IN cord-326673-p8qbxi57 62 3 the the DT cord-326673-p8qbxi57 62 4 antibody antibody NN cord-326673-p8qbxi57 62 5 response response NN cord-326673-p8qbxi57 62 6 to to IN cord-326673-p8qbxi57 62 7 rabies rabies NN cord-326673-p8qbxi57 62 8 virus virus NN cord-326673-p8qbxi57 62 9 vaccination vaccination NN cord-326673-p8qbxi57 62 10 in in IN cord-326673-p8qbxi57 62 11 both both CC cord-326673-p8qbxi57 62 12 the the DT cord-326673-p8qbxi57 62 13 dog dog NN cord-326673-p8qbxi57 62 14 ( ( -LRB- cord-326673-p8qbxi57 62 15 Aghomo Aghomo NNP cord-326673-p8qbxi57 62 16 et et NNP cord-326673-p8qbxi57 62 17 aL aL NNP cord-326673-p8qbxi57 62 18 , , , cord-326673-p8qbxi57 62 19 1990 1990 CD cord-326673-p8qbxi57 62 20 ) ) -RRB- cord-326673-p8qbxi57 62 21 and and CC cord-326673-p8qbxi57 62 22 the the DT cord-326673-p8qbxi57 62 23 mouse mouse NN cord-326673-p8qbxi57 62 24 ( ( -LRB- cord-326673-p8qbxi57 62 25 Xiang Xiang NNP cord-326673-p8qbxi57 62 26 & & CC cord-326673-p8qbxi57 62 27 Erfl Erfl NNP cord-326673-p8qbxi57 62 28 , , , cord-326673-p8qbxi57 62 29 1992 1992 CD cord-326673-p8qbxi57 62 30 ) ) -RRB- cord-326673-p8qbxi57 62 31 has have VBZ cord-326673-p8qbxi57 62 32 been be VBN cord-326673-p8qbxi57 62 33 shown show VBN cord-326673-p8qbxi57 62 34 to to TO cord-326673-p8qbxi57 62 35 occur occur VB cord-326673-p8qbxi57 62 36 for for IN cord-326673-p8qbxi57 62 37 considerable considerable JJ cord-326673-p8qbxi57 62 38 periods period NNS cord-326673-p8qbxi57 62 39 after after IN cord-326673-p8qbxi57 62 40 MDA MDA NNP cord-326673-p8qbxi57 62 41 has have VBZ cord-326673-p8qbxi57 62 42 fallen fall VBN cord-326673-p8qbxi57 62 43 below below IN cord-326673-p8qbxi57 62 44 detectable detectable JJ cord-326673-p8qbxi57 62 45 levels level NNS cord-326673-p8qbxi57 62 46 . . . cord-326673-p8qbxi57 63 1 In in IN cord-326673-p8qbxi57 63 2 the the DT cord-326673-p8qbxi57 63 3 mouse mouse NN cord-326673-p8qbxi57 63 4 system system NN cord-326673-p8qbxi57 63 5 the the DT cord-326673-p8qbxi57 63 6 suppression suppression NN cord-326673-p8qbxi57 63 7 of of IN cord-326673-p8qbxi57 63 8 in in FW cord-326673-p8qbxi57 63 9 vitro vitro FW cord-326673-p8qbxi57 63 10 T T NNP cord-326673-p8qbxi57 63 11 lymphoproliferation lymphoproliferation NN cord-326673-p8qbxi57 63 12 responses response NNS cord-326673-p8qbxi57 63 13 was be VBD cord-326673-p8qbxi57 63 14 more more RBR cord-326673-p8qbxi57 63 15 prolonged prolonged JJ cord-326673-p8qbxi57 63 16 than than IN cord-326673-p8qbxi57 63 17 the the DT cord-326673-p8qbxi57 63 18 effect effect NN cord-326673-p8qbxi57 63 19 on on IN cord-326673-p8qbxi57 63 20 the the DT cord-326673-p8qbxi57 63 21 antibody antibody NN cord-326673-p8qbxi57 63 22 response response NN cord-326673-p8qbxi57 63 23 . . . cord-326673-p8qbxi57 64 1 The the DT cord-326673-p8qbxi57 64 2 authors author NNS cord-326673-p8qbxi57 64 3 concluded conclude VBD cord-326673-p8qbxi57 64 4 that that IN cord-326673-p8qbxi57 64 5 in in IN cord-326673-p8qbxi57 64 6 this this DT cord-326673-p8qbxi57 64 7 experimental experimental JJ cord-326673-p8qbxi57 64 8 system system NN cord-326673-p8qbxi57 64 9 MDA MDA NNP cord-326673-p8qbxi57 64 10 - - HYPH cord-326673-p8qbxi57 64 11 induced induce VBN cord-326673-p8qbxi57 64 12 T t NN cord-326673-p8qbxi57 64 13 suppressor suppressor NN cord-326673-p8qbxi57 64 14 cells cell NNS cord-326673-p8qbxi57 64 15 were be VBD cord-326673-p8qbxi57 64 16 responsible responsible JJ cord-326673-p8qbxi57 64 17 for for IN cord-326673-p8qbxi57 64 18 vaccination vaccination NN cord-326673-p8qbxi57 64 19 failure failure NN cord-326673-p8qbxi57 64 20 in in IN cord-326673-p8qbxi57 64 21 these these DT cord-326673-p8qbxi57 64 22 neonatal neonatal JJ cord-326673-p8qbxi57 64 23 mice mouse NNS cord-326673-p8qbxi57 64 24 rather rather RB cord-326673-p8qbxi57 64 25 than than IN cord-326673-p8qbxi57 64 26 a a DT cord-326673-p8qbxi57 64 27 simple simple JJ cord-326673-p8qbxi57 64 28 reduction reduction NN cord-326673-p8qbxi57 64 29 in in IN cord-326673-p8qbxi57 64 30 antigenic antigenic JJ cord-326673-p8qbxi57 64 31 load load NN cord-326673-p8qbxi57 64 32 . . . cord-326673-p8qbxi57 65 1 In in IN cord-326673-p8qbxi57 65 2 addition addition NN cord-326673-p8qbxi57 65 3 to to IN cord-326673-p8qbxi57 65 4 the the DT cord-326673-p8qbxi57 65 5 MDA MDA NNP cord-326673-p8qbxi57 65 6 - - HYPH cord-326673-p8qbxi57 65 7 mediated mediate VBN cord-326673-p8qbxi57 65 8 effects effect NNS cord-326673-p8qbxi57 65 9 on on IN cord-326673-p8qbxi57 65 10 neonatal neonatal JJ cord-326673-p8qbxi57 65 11 immunocompetence immunocompetence NN cord-326673-p8qbxi57 65 12 in in IN cord-326673-p8qbxi57 65 13 the the DT cord-326673-p8qbxi57 65 14 mouse mouse NN cord-326673-p8qbxi57 65 15 , , , cord-326673-p8qbxi57 65 16 Fujii Fujii NNP cord-326673-p8qbxi57 65 17 and and CC cord-326673-p8qbxi57 65 18 Yamaguchi Yamaguchi NNP cord-326673-p8qbxi57 65 19 ( ( -LRB- cord-326673-p8qbxi57 65 20 1992 1992 CD cord-326673-p8qbxi57 65 21 ) ) -RRB- cord-326673-p8qbxi57 65 22 reported report VBD cord-326673-p8qbxi57 65 23 that that IN cord-326673-p8qbxi57 65 24 immunization immunization NN cord-326673-p8qbxi57 65 25 of of IN cord-326673-p8qbxi57 65 26 pregnant pregnant JJ cord-326673-p8qbxi57 65 27 mice mouse NNS cord-326673-p8qbxi57 65 28 induced induce VBN cord-326673-p8qbxi57 65 29 CD4 CD4 NNP cord-326673-p8qbxi57 65 30 + + CC cord-326673-p8qbxi57 65 31 T t NN cord-326673-p8qbxi57 65 32 lymphocytes lymphocyte NNS cord-326673-p8qbxi57 65 33 which which WDT cord-326673-p8qbxi57 65 34 were be VBD cord-326673-p8qbxi57 65 35 capable capable JJ cord-326673-p8qbxi57 65 36 of of IN cord-326673-p8qbxi57 65 37 either either DT cord-326673-p8qbxi57 65 38 producing produce VBG cord-326673-p8qbxi57 65 39 a a DT cord-326673-p8qbxi57 65 40 suppressive suppressive JJ cord-326673-p8qbxi57 65 41 factor factor NN cord-326673-p8qbxi57 65 42 themselves -PRON- PRP cord-326673-p8qbxi57 65 43 or or CC cord-326673-p8qbxi57 65 44 stimulating stimulate VBG cord-326673-p8qbxi57 65 45 a a DT cord-326673-p8qbxi57 65 46 population population NN cord-326673-p8qbxi57 65 47 of of IN cord-326673-p8qbxi57 65 48 T t NN cord-326673-p8qbxi57 65 49 suppressor suppressor NN cord-326673-p8qbxi57 65 50 cells cell NNS cord-326673-p8qbxi57 65 51 to to TO cord-326673-p8qbxi57 65 52 secrete secrete VB cord-326673-p8qbxi57 65 53 such such PDT cord-326673-p8qbxi57 65 54 a a DT cord-326673-p8qbxi57 65 55 factor factor NN cord-326673-p8qbxi57 65 56 that that WDT cord-326673-p8qbxi57 65 57 could could MD cord-326673-p8qbxi57 65 58 cross cross VB cord-326673-p8qbxi57 65 59 the the DT cord-326673-p8qbxi57 65 60 placenta placenta NN cord-326673-p8qbxi57 65 61 and and CC cord-326673-p8qbxi57 65 62 induce induce VB cord-326673-p8qbxi57 65 63 specific specific JJ cord-326673-p8qbxi57 65 64 humoral humoral JJ cord-326673-p8qbxi57 65 65 and and CC cord-326673-p8qbxi57 65 66 cellular cellular JJ cord-326673-p8qbxi57 65 67 immunosuppression immunosuppression NN cord-326673-p8qbxi57 65 68 in in IN cord-326673-p8qbxi57 65 69 the the DT cord-326673-p8qbxi57 65 70 neonate neonate NN cord-326673-p8qbxi57 65 71 . . . cord-326673-p8qbxi57 66 1 One one CD cord-326673-p8qbxi57 66 2 of of IN cord-326673-p8qbxi57 66 3 the the DT cord-326673-p8qbxi57 66 4 authors author NNS cord-326673-p8qbxi57 66 5 has have VBZ cord-326673-p8qbxi57 66 6 also also RB cord-326673-p8qbxi57 66 7 previously previously RB cord-326673-p8qbxi57 66 8 reported report VBN cord-326673-p8qbxi57 66 9 the the DT cord-326673-p8qbxi57 66 10 induction induction NN cord-326673-p8qbxi57 66 11 in in IN cord-326673-p8qbxi57 66 12 mice mouse NNS cord-326673-p8qbxi57 66 13 of of IN cord-326673-p8qbxi57 66 14 suppressor suppressor NN cord-326673-p8qbxi57 66 15 T t NN cord-326673-p8qbxi57 66 16 cells cell NNS cord-326673-p8qbxi57 66 17 in in IN cord-326673-p8qbxi57 66 18 offspring offspre VBG cord-326673-p8qbxi57 66 19 following follow VBG cord-326673-p8qbxi57 66 20 maternal maternal JJ cord-326673-p8qbxi57 66 21 immunization immunization NN cord-326673-p8qbxi57 67 1 ( ( -LRB- cord-326673-p8qbxi57 67 2 Koshimo Koshimo NNP cord-326673-p8qbxi57 67 3 et et NNP cord-326673-p8qbxi57 67 4 al al NNP cord-326673-p8qbxi57 67 5 . . NNP cord-326673-p8qbxi57 67 6 , , , cord-326673-p8qbxi57 67 7 1989 1989 CD cord-326673-p8qbxi57 67 8 ) ) -RRB- cord-326673-p8qbxi57 67 9 . . . cord-326673-p8qbxi57 68 1 Imnaunocompetent Imnaunocompetent NNP cord-326673-p8qbxi57 68 2 cells cell NNS cord-326673-p8qbxi57 68 3 and and CC cord-326673-p8qbxi57 68 4 various various JJ cord-326673-p8qbxi57 68 5 factors factor NNS cord-326673-p8qbxi57 68 6 are be VBP cord-326673-p8qbxi57 68 7 absorbed absorb VBN cord-326673-p8qbxi57 68 8 by by IN cord-326673-p8qbxi57 68 9 the the DT cord-326673-p8qbxi57 68 10 gut gut NN cord-326673-p8qbxi57 68 11 during during IN cord-326673-p8qbxi57 68 12 the the DT cord-326673-p8qbxi57 68 13 first first JJ cord-326673-p8qbxi57 68 14 36 36 CD cord-326673-p8qbxi57 68 15 h h NN cord-326673-p8qbxi57 68 16 of of IN cord-326673-p8qbxi57 68 17 life life NN cord-326673-p8qbxi57 68 18 in in IN cord-326673-p8qbxi57 68 19 the the DT cord-326673-p8qbxi57 68 20 domesticated domesticate VBN cord-326673-p8qbxi57 68 21 species specie NNS cord-326673-p8qbxi57 68 22 and and CC cord-326673-p8qbxi57 68 23 , , , cord-326673-p8qbxi57 68 24 therefore therefore RB cord-326673-p8qbxi57 68 25 , , , cord-326673-p8qbxi57 68 26 it -PRON- PRP cord-326673-p8qbxi57 68 27 is be VBZ cord-326673-p8qbxi57 68 28 possible possible JJ cord-326673-p8qbxi57 68 29 that that IN cord-326673-p8qbxi57 68 30 these these DT cord-326673-p8qbxi57 68 31 may may MD cord-326673-p8qbxi57 68 32 have have VB cord-326673-p8qbxi57 68 33 a a DT cord-326673-p8qbxi57 68 34 regulato~ regulato~ NNP cord-326673-p8qbxi57 68 35 T T NNP cord-326673-p8qbxi57 68 36 effect effect NN cord-326673-p8qbxi57 68 37 on on IN cord-326673-p8qbxi57 68 38 the the DT cord-326673-p8qbxi57 68 39 immature immature JJ cord-326673-p8qbxi57 68 40 immune immune JJ cord-326673-p8qbxi57 68 41 system system NN cord-326673-p8qbxi57 68 42 in in IN cord-326673-p8qbxi57 68 43 these these DT cord-326673-p8qbxi57 68 44 species specie NNS cord-326673-p8qbxi57 68 45 similar similar JJ cord-326673-p8qbxi57 68 46 to to IN cord-326673-p8qbxi57 68 47 the the DT cord-326673-p8qbxi57 68 48 transplacental transplacental JJ cord-326673-p8qbxi57 68 49 factors factor NNS cord-326673-p8qbxi57 68 50 in in IN cord-326673-p8qbxi57 68 51 mice mouse NNS cord-326673-p8qbxi57 68 52 ( ( -LRB- cord-326673-p8qbxi57 68 53 Palmerly Palmerly NNP cord-326673-p8qbxi57 68 54 & & CC cord-326673-p8qbxi57 68 55 Beer Beer NNP cord-326673-p8qbxi57 68 56 , , , cord-326673-p8qbxi57 68 57 1977 1977 CD cord-326673-p8qbxi57 68 58 ) ) -RRB- cord-326673-p8qbxi57 68 59 . . . cord-326673-p8qbxi57 69 1 In in IN cord-326673-p8qbxi57 69 2 the the DT cord-326673-p8qbxi57 69 3 case case NN cord-326673-p8qbxi57 69 4 of of IN cord-326673-p8qbxi57 69 5 FMD FMD NNP cord-326673-p8qbxi57 69 6 vaccination vaccination NN cord-326673-p8qbxi57 69 7 in in IN cord-326673-p8qbxi57 69 8 pigs pig NNS cord-326673-p8qbxi57 69 9 , , , cord-326673-p8qbxi57 69 10 Francis Francis NNP cord-326673-p8qbxi57 69 11 and and CC cord-326673-p8qbxi57 69 12 Black Black NNP cord-326673-p8qbxi57 69 13 ( ( -LRB- cord-326673-p8qbxi57 69 14 1986 1986 CD cord-326673-p8qbxi57 69 15 ) ) -RRB- cord-326673-p8qbxi57 69 16 concluded conclude VBD cord-326673-p8qbxi57 69 17 that that IN cord-326673-p8qbxi57 69 18 the the DT cord-326673-p8qbxi57 69 19 complete complete JJ cord-326673-p8qbxi57 69 20 immunological immunological JJ cord-326673-p8qbxi57 69 21 unresponsiveness unresponsiveness NN cord-326673-p8qbxi57 69 22 seen see VBN cord-326673-p8qbxi57 69 23 in in IN cord-326673-p8qbxi57 69 24 the the DT cord-326673-p8qbxi57 69 25 first first JJ cord-326673-p8qbxi57 69 26 2 2 CD cord-326673-p8qbxi57 69 27 weeks week NNS cord-326673-p8qbxi57 69 28 of of IN cord-326673-p8qbxi57 69 29 life life NN cord-326673-p8qbxi57 69 30 was be VBD cord-326673-p8qbxi57 69 31 due due JJ cord-326673-p8qbxi57 69 32 to to IN cord-326673-p8qbxi57 69 33 immaturity immaturity NN cord-326673-p8qbxi57 69 34 of of IN cord-326673-p8qbxi57 69 35 the the DT cord-326673-p8qbxi57 69 36 immune immune JJ cord-326673-p8qbxi57 69 37 system system NN cord-326673-p8qbxi57 69 38 and and CC cord-326673-p8qbxi57 69 39 antigen antigen NN cord-326673-p8qbxi57 69 40 blockade blockade NN cord-326673-p8qbxi57 69 41 by by IN cord-326673-p8qbxi57 69 42 high high JJ cord-326673-p8qbxi57 69 43 titre titre NN cord-326673-p8qbxi57 69 44 MDA MDA NNP cord-326673-p8qbxi57 69 45 , , , cord-326673-p8qbxi57 69 46 and and CC cord-326673-p8qbxi57 69 47 as as IN cord-326673-p8qbxi57 69 48 this this DT cord-326673-p8qbxi57 69 49 titre titre NN cord-326673-p8qbxi57 69 50 declined decline VBD cord-326673-p8qbxi57 69 51 an an DT cord-326673-p8qbxi57 69 52 active active JJ cord-326673-p8qbxi57 69 53 suppression suppression NN cord-326673-p8qbxi57 69 54 of of IN cord-326673-p8qbxi57 69 55 T T NNP cord-326673-p8qbxi57 69 56 and/or and/or CC cord-326673-p8qbxi57 69 57 B B NNP cord-326673-p8qbxi57 69 58 cells cell NNS cord-326673-p8qbxi57 69 59 occurred occur VBD cord-326673-p8qbxi57 69 60 to to IN cord-326673-p8qbxi57 69 61 variable variable JJ cord-326673-p8qbxi57 69 62 degrees degree NNS cord-326673-p8qbxi57 69 63 . . . cord-326673-p8qbxi57 70 1 The the DT cord-326673-p8qbxi57 70 2 degree degree NN cord-326673-p8qbxi57 70 3 of of IN cord-326673-p8qbxi57 70 4 inhibition inhibition NN cord-326673-p8qbxi57 70 5 of of IN cord-326673-p8qbxi57 70 6 the the DT cord-326673-p8qbxi57 70 7 antibody antibody NN cord-326673-p8qbxi57 70 8 response response NN cord-326673-p8qbxi57 70 9 in in IN cord-326673-p8qbxi57 70 10 these these DT cord-326673-p8qbxi57 70 11 piglets piglet NNS cord-326673-p8qbxi57 70 12 was be VBD cord-326673-p8qbxi57 70 13 directly directly RB cord-326673-p8qbxi57 70 14 proportional proportional JJ cord-326673-p8qbxi57 70 15 to to IN cord-326673-p8qbxi57 70 16 the the DT cord-326673-p8qbxi57 70 17 MDA MDA NNP cord-326673-p8qbxi57 70 18 titre titre NN cord-326673-p8qbxi57 70 19 at at IN cord-326673-p8qbxi57 70 20 the the DT cord-326673-p8qbxi57 70 21 time time NN cord-326673-p8qbxi57 70 22 of of IN cord-326673-p8qbxi57 70 23 vaccination vaccination NN cord-326673-p8qbxi57 70 24 . . . cord-326673-p8qbxi57 71 1 This this DT cord-326673-p8qbxi57 71 2 was be VBD cord-326673-p8qbxi57 71 3 reflected reflect VBN cord-326673-p8qbxi57 71 4 in in IN cord-326673-p8qbxi57 71 5 the the DT cord-326673-p8qbxi57 71 6 outcome outcome NN cord-326673-p8qbxi57 71 7 of of IN cord-326673-p8qbxi57 71 8 the the DT cord-326673-p8qbxi57 71 9 challenge challenge NN cord-326673-p8qbxi57 71 10 experiment experiment NN cord-326673-p8qbxi57 71 11 which which WDT cord-326673-p8qbxi57 71 12 showed show VBD cord-326673-p8qbxi57 71 13 that that IN cord-326673-p8qbxi57 71 14 whereas whereas IN cord-326673-p8qbxi57 71 15 partial partial JJ cord-326673-p8qbxi57 71 16 protection protection NN cord-326673-p8qbxi57 71 17 was be VBD cord-326673-p8qbxi57 71 18 achieved achieve VBN cord-326673-p8qbxi57 71 19 by by IN cord-326673-p8qbxi57 71 20 vaccination vaccination NN cord-326673-p8qbxi57 71 21 at at IN cord-326673-p8qbxi57 71 22 8 8 CD cord-326673-p8qbxi57 71 23 weeks week NNS cord-326673-p8qbxi57 71 24 old old JJ cord-326673-p8qbxi57 71 25 , , , cord-326673-p8qbxi57 71 26 earlier early JJR cord-326673-p8qbxi57 71 27 vaccination vaccination NN cord-326673-p8qbxi57 71 28 conferred confer VBD cord-326673-p8qbxi57 71 29 no no DT cord-326673-p8qbxi57 71 30 protection protection NN cord-326673-p8qbxi57 71 31 to to IN cord-326673-p8qbxi57 71 32 FMDV fmdv JJ cord-326673-p8qbxi57 71 33 challenge challenge NN cord-326673-p8qbxi57 71 34 after after IN cord-326673-p8qbxi57 71 35 6 6 CD cord-326673-p8qbxi57 71 36 months month NNS cord-326673-p8qbxi57 71 37 . . . cord-326673-p8qbxi57 72 1 In in IN cord-326673-p8qbxi57 72 2 this this DT cord-326673-p8qbxi57 72 3 same same JJ cord-326673-p8qbxi57 72 4 study study NN cord-326673-p8qbxi57 72 5 it -PRON- PRP cord-326673-p8qbxi57 72 6 was be VBD cord-326673-p8qbxi57 72 7 possible possible JJ cord-326673-p8qbxi57 72 8 to to TO cord-326673-p8qbxi57 72 9 elicit elicit VB cord-326673-p8qbxi57 72 10 a a DT cord-326673-p8qbxi57 72 11 primary primary JJ cord-326673-p8qbxi57 72 12 antibody antibody NN cord-326673-p8qbxi57 72 13 response response NN cord-326673-p8qbxi57 72 14 , , , cord-326673-p8qbxi57 72 15 consisting consist VBG cord-326673-p8qbxi57 72 16 of of IN cord-326673-p8qbxi57 72 17 IgM IgM NNP cord-326673-p8qbxi57 72 18 , , , cord-326673-p8qbxi57 72 19 at at IN cord-326673-p8qbxi57 72 20 an an DT cord-326673-p8qbxi57 72 21 age age NN cord-326673-p8qbxi57 72 22 when when WRB cord-326673-p8qbxi57 72 23 IgA IgA NNP cord-326673-p8qbxi57 72 24 and and CC cord-326673-p8qbxi57 72 25 IgG IgG NNP cord-326673-p8qbxi57 72 26 responses response NNS cord-326673-p8qbxi57 72 27 were be VBD cord-326673-p8qbxi57 72 28 totally totally RB cord-326673-p8qbxi57 72 29 suppressed suppress VBN cord-326673-p8qbxi57 72 30 . . . cord-326673-p8qbxi57 73 1 This this DT cord-326673-p8qbxi57 73 2 observation observation NN cord-326673-p8qbxi57 73 3 supports support VBZ cord-326673-p8qbxi57 73 4 the the DT cord-326673-p8qbxi57 73 5 view view NN cord-326673-p8qbxi57 73 6 that that IN cord-326673-p8qbxi57 73 7 a a DT cord-326673-p8qbxi57 73 8 period period NN cord-326673-p8qbxi57 73 9 of of IN cord-326673-p8qbxi57 73 10 T t NN cord-326673-p8qbxi57 73 11 lymphocyte lymphocyte NN cord-326673-p8qbxi57 73 12 immunosuppression immunosuppression NN cord-326673-p8qbxi57 73 13 follows follow VBZ cord-326673-p8qbxi57 73 14 the the DT cord-326673-p8qbxi57 73 15 initial initial JJ cord-326673-p8qbxi57 73 16 state state NN cord-326673-p8qbxi57 73 17 of of IN cord-326673-p8qbxi57 73 18 unresponsiveness unresponsiveness NN cord-326673-p8qbxi57 73 19 , , , cord-326673-p8qbxi57 73 20 and and CC cord-326673-p8qbxi57 73 21 that that IN cord-326673-p8qbxi57 73 22 this this DT cord-326673-p8qbxi57 73 23 interferes interfere VBZ cord-326673-p8qbxi57 73 24 with with IN cord-326673-p8qbxi57 73 25 the the DT cord-326673-p8qbxi57 73 26 generation generation NN cord-326673-p8qbxi57 73 27 of of IN cord-326673-p8qbxi57 73 28 secondary secondary JJ cord-326673-p8qbxi57 73 29 antibody antibody NN cord-326673-p8qbxi57 73 30 responses response NNS cord-326673-p8qbxi57 73 31 . . . cord-326673-p8qbxi57 74 1 In in IN cord-326673-p8qbxi57 74 2 this this DT cord-326673-p8qbxi57 74 3 case case NN cord-326673-p8qbxi57 74 4 the the DT cord-326673-p8qbxi57 74 5 suppression suppression NN cord-326673-p8qbxi57 74 6 acts act NNS cord-326673-p8qbxi57 74 7 after after IN cord-326673-p8qbxi57 74 8 the the DT cord-326673-p8qbxi57 74 9 initial initial JJ cord-326673-p8qbxi57 74 10 stage stage NN cord-326673-p8qbxi57 74 11 of of IN cord-326673-p8qbxi57 74 12 antigenprocessing antigenprocesse VBG cord-326673-p8qbxi57 74 13 and and CC cord-326673-p8qbxi57 74 14 recognition recognition NN cord-326673-p8qbxi57 74 15 by by IN cord-326673-p8qbxi57 74 16 B b NN cord-326673-p8qbxi57 74 17 cells cell NNS cord-326673-p8qbxi57 74 18 , , , cord-326673-p8qbxi57 74 19 and and CC cord-326673-p8qbxi57 74 20 affects affect VBZ cord-326673-p8qbxi57 74 21 the the DT cord-326673-p8qbxi57 74 22 regulation regulation NN cord-326673-p8qbxi57 74 23 of of IN cord-326673-p8qbxi57 74 24 the the DT cord-326673-p8qbxi57 74 25 evolution evolution NN cord-326673-p8qbxi57 74 26 of of IN cord-326673-p8qbxi57 74 27 the the DT cord-326673-p8qbxi57 74 28 antibody antibody NN cord-326673-p8qbxi57 74 29 response response NN cord-326673-p8qbxi57 74 30 by by IN cord-326673-p8qbxi57 74 31 interference interference NN cord-326673-p8qbxi57 74 32 with with IN cord-326673-p8qbxi57 74 33 clonal clonal JJ cord-326673-p8qbxi57 74 34 expansion expansion NN cord-326673-p8qbxi57 74 35 and and CC cord-326673-p8qbxi57 74 36 antibody antibody NN cord-326673-p8qbxi57 74 37 isotype isotype NN cord-326673-p8qbxi57 74 38 - - HYPH cord-326673-p8qbxi57 74 39 switching switching NN cord-326673-p8qbxi57 74 40 , , , cord-326673-p8qbxi57 74 41 both both DT cord-326673-p8qbxi57 74 42 of of IN cord-326673-p8qbxi57 74 43 which which WDT cord-326673-p8qbxi57 74 44 are be VBP cord-326673-p8qbxi57 74 45 necessary necessary JJ cord-326673-p8qbxi57 74 46 for for IN cord-326673-p8qbxi57 74 47 a a DT cord-326673-p8qbxi57 74 48 secondary secondary JJ cord-326673-p8qbxi57 74 49 response response NN cord-326673-p8qbxi57 74 50 and and CC cord-326673-p8qbxi57 74 51 the the DT cord-326673-p8qbxi57 74 52 generation generation NN cord-326673-p8qbxi57 74 53 of of IN cord-326673-p8qbxi57 74 54 ' ' `` cord-326673-p8qbxi57 74 55 immunological immunological JJ cord-326673-p8qbxi57 74 56 memory memory NN cord-326673-p8qbxi57 74 57 ' ' '' cord-326673-p8qbxi57 74 58 , , , cord-326673-p8qbxi57 74 59 and and CC cord-326673-p8qbxi57 74 60 thus thus RB cord-326673-p8qbxi57 74 61 long long JJ cord-326673-p8qbxi57 74 62 - - HYPH cord-326673-p8qbxi57 74 63 term term NN cord-326673-p8qbxi57 74 64 protection protection NN cord-326673-p8qbxi57 74 65 . . . cord-326673-p8qbxi57 75 1 Similar similar JJ cord-326673-p8qbxi57 75 2 results result NNS cord-326673-p8qbxi57 75 3 have have VBP cord-326673-p8qbxi57 75 4 been be VBN cord-326673-p8qbxi57 75 5 reported report VBN cord-326673-p8qbxi57 75 6 from from IN cord-326673-p8qbxi57 75 7 studies study NNS cord-326673-p8qbxi57 75 8 on on IN cord-326673-p8qbxi57 75 9 the the DT cord-326673-p8qbxi57 75 10 effects effect NNS cord-326673-p8qbxi57 75 11 of of IN cord-326673-p8qbxi57 75 12 MDA MDA NNP cord-326673-p8qbxi57 75 13 on on IN cord-326673-p8qbxi57 75 14 vaccination vaccination NN cord-326673-p8qbxi57 75 15 of of IN cord-326673-p8qbxi57 75 16 calves calf NNS cord-326673-p8qbxi57 75 17 against against IN cord-326673-p8qbxi57 75 18 several several JJ cord-326673-p8qbxi57 75 19 viral viral JJ cord-326673-p8qbxi57 75 20 diseases disease NNS cord-326673-p8qbxi57 75 21 ( ( -LRB- cord-326673-p8qbxi57 75 22 Marshall Marshall NNP cord-326673-p8qbxi57 75 23 & & CC cord-326673-p8qbxi57 75 24 Frank Frank NNP cord-326673-p8qbxi57 75 25 , , , cord-326673-p8qbxi57 75 26 1975 1975 CD cord-326673-p8qbxi57 75 27 ; ; : cord-326673-p8qbxi57 75 28 Kimman Kimman NNP cord-326673-p8qbxi57 75 29 et et NNP cord-326673-p8qbxi57 75 30 al al NNP cord-326673-p8qbxi57 75 31 . . NNP cord-326673-p8qbxi57 75 32 , , , cord-326673-p8qbxi57 75 33 1988 1988 CD cord-326673-p8qbxi57 75 34 ) ) -RRB- cord-326673-p8qbxi57 75 35 . . . cord-326673-p8qbxi57 76 1 Vaccination vaccination NN cord-326673-p8qbxi57 76 2 of of IN cord-326673-p8qbxi57 76 3 calves calf NNS cord-326673-p8qbxi57 76 4 with with IN cord-326673-p8qbxi57 76 5 high high JJ cord-326673-p8qbxi57 76 6 MDA MDA NNP cord-326673-p8qbxi57 76 7 titres titre NNS cord-326673-p8qbxi57 76 8 at at IN cord-326673-p8qbxi57 76 9 1-week 1-week CD cord-326673-p8qbxi57 76 10 - - JJ cord-326673-p8qbxi57 76 11 old old JJ cord-326673-p8qbxi57 76 12 inhibited inhibit VBD cord-326673-p8qbxi57 76 13 the the DT cord-326673-p8qbxi57 76 14 active active JJ cord-326673-p8qbxi57 76 15 production production NN cord-326673-p8qbxi57 76 16 of of IN cord-326673-p8qbxi57 76 17 antibody antibody NN cord-326673-p8qbxi57 76 18 to to IN cord-326673-p8qbxi57 76 19 bovine bovine JJ cord-326673-p8qbxi57 76 20 coronavirus coronavirus NN cord-326673-p8qbxi57 76 21 ( ( -LRB- cord-326673-p8qbxi57 76 22 Heckert Heckert NNP cord-326673-p8qbxi57 76 23 et et NNP cord-326673-p8qbxi57 76 24 al al NNP cord-326673-p8qbxi57 76 25 . . NNP cord-326673-p8qbxi57 76 26 , , , cord-326673-p8qbxi57 76 27 1991 1991 CD cord-326673-p8qbxi57 76 28 ) ) -RRB- cord-326673-p8qbxi57 76 29 . . . cord-326673-p8qbxi57 77 1 Again again RB cord-326673-p8qbxi57 77 2 the the DT cord-326673-p8qbxi57 77 3 IgM IgM NNP cord-326673-p8qbxi57 77 4 response response NN cord-326673-p8qbxi57 77 5 was be VBD cord-326673-p8qbxi57 77 6 least least RBS cord-326673-p8qbxi57 77 7 susceptible susceptible JJ cord-326673-p8qbxi57 77 8 to to IN cord-326673-p8qbxi57 77 9 the the DT cord-326673-p8qbxi57 77 10 suppressive suppressive JJ cord-326673-p8qbxi57 77 11 effects effect NNS cord-326673-p8qbxi57 77 12 of of IN cord-326673-p8qbxi57 77 13 MDA MDA NNP cord-326673-p8qbxi57 77 14 in in IN cord-326673-p8qbxi57 77 15 these these DT cord-326673-p8qbxi57 77 16 calves calf NNS cord-326673-p8qbxi57 77 17 , , , cord-326673-p8qbxi57 77 18 whereas whereas IN cord-326673-p8qbxi57 77 19 both both CC cord-326673-p8qbxi57 77 20 the the DT cord-326673-p8qbxi57 77 21 serum serum NN cord-326673-p8qbxi57 77 22 IgG~ IgG~ NNS cord-326673-p8qbxi57 77 23 and and CC cord-326673-p8qbxi57 77 24 secretory secretory JJ cord-326673-p8qbxi57 77 25 IgA IgA NNP cord-326673-p8qbxi57 77 26 responses response NNS cord-326673-p8qbxi57 77 27 were be VBD cord-326673-p8qbxi57 77 28 markedly markedly RB cord-326673-p8qbxi57 77 29 depressed depressed JJ cord-326673-p8qbxi57 77 30 . . . cord-326673-p8qbxi57 78 1 However however RB cord-326673-p8qbxi57 78 2 , , , cord-326673-p8qbxi57 78 3 it -PRON- PRP cord-326673-p8qbxi57 78 4 is be VBZ cord-326673-p8qbxi57 78 5 notable notable JJ cord-326673-p8qbxi57 78 6 that that IN cord-326673-p8qbxi57 78 7 the the DT cord-326673-p8qbxi57 78 8 degree degree NN cord-326673-p8qbxi57 78 9 of of IN cord-326673-p8qbxi57 78 10 suppression suppression NN cord-326673-p8qbxi57 78 11 to to IN cord-326673-p8qbxi57 78 12 the the DT cord-326673-p8qbxi57 78 13 different different JJ cord-326673-p8qbxi57 78 14 coronavirus coronavirus NN cord-326673-p8qbxi57 78 15 proteins protein NNS cord-326673-p8qbxi57 78 16 was be VBD cord-326673-p8qbxi57 78 17 not not RB cord-326673-p8qbxi57 78 18 uniform uniform JJ cord-326673-p8qbxi57 78 19 , , , cord-326673-p8qbxi57 78 20 and and CC cord-326673-p8qbxi57 78 21 the the DT cord-326673-p8qbxi57 78 22 attthors attthor NNS cord-326673-p8qbxi57 78 23 suggest suggest VBP cord-326673-p8qbxi57 78 24 that that IN cord-326673-p8qbxi57 78 25 the the DT cord-326673-p8qbxi57 78 26 more more RBR cord-326673-p8qbxi57 78 27 immunogenic immunogenic JJ cord-326673-p8qbxi57 78 28 viral viral JJ cord-326673-p8qbxi57 78 29 proteins protein NNS cord-326673-p8qbxi57 78 30 may may MD cord-326673-p8qbxi57 78 31 be be VB cord-326673-p8qbxi57 78 32 able able JJ cord-326673-p8qbxi57 78 33 to to TO cord-326673-p8qbxi57 78 34 elicit elicit VB cord-326673-p8qbxi57 78 35 antibody antibody NN cord-326673-p8qbxi57 78 36 responses response NNS cord-326673-p8qbxi57 78 37 at at IN cord-326673-p8qbxi57 78 38 MDA MDA NNP cord-326673-p8qbxi57 78 39 titres titre NNS cord-326673-p8qbxi57 78 40 that that WDT cord-326673-p8qbxi57 78 41 inhibit inhibit VBP cord-326673-p8qbxi57 78 42 the the DT cord-326673-p8qbxi57 78 43 response response NN cord-326673-p8qbxi57 78 44 to to IN cord-326673-p8qbxi57 78 45 other other JJ cord-326673-p8qbxi57 78 46 proteins protein NNS cord-326673-p8qbxi57 78 47 . . . cord-326673-p8qbxi57 79 1 The the DT cord-326673-p8qbxi57 79 2 reported report VBN cord-326673-p8qbxi57 79 3 success success NN cord-326673-p8qbxi57 79 4 of of IN cord-326673-p8qbxi57 79 5 oil oil NN cord-326673-p8qbxi57 79 6 - - HYPH cord-326673-p8qbxi57 79 7 emulsion emulsion NN cord-326673-p8qbxi57 79 8 vaccines vaccine NNS cord-326673-p8qbxi57 79 9 in in IN cord-326673-p8qbxi57 79 10 the the DT cord-326673-p8qbxi57 79 11 face face NN cord-326673-p8qbxi57 79 12 of of IN cord-326673-p8qbxi57 79 13 high high JJ cord-326673-p8qbxi57 79 14 MDA MDA NNP cord-326673-p8qbxi57 79 15 titres titre NNS cord-326673-p8qbxi57 79 16 may may MD cord-326673-p8qbxi57 79 17 also also RB cord-326673-p8qbxi57 79 18 be be VB cord-326673-p8qbxi57 79 19 due due JJ cord-326673-p8qbxi57 79 20 to to IN cord-326673-p8qbxi57 79 21 improved improve VBN cord-326673-p8qbxi57 79 22 immunogenicity immunogenicity NN cord-326673-p8qbxi57 79 23 ( ( -LRB- cord-326673-p8qbxi57 79 24 Morgan Morgan NNP cord-326673-p8qbxi57 79 25 & & CC cord-326673-p8qbxi57 79 26 McKercher McKercher NNP cord-326673-p8qbxi57 79 27 , , , cord-326673-p8qbxi57 79 28 1977 1977 CD cord-326673-p8qbxi57 79 29 ) ) -RRB- cord-326673-p8qbxi57 79 30 . . . cord-326673-p8qbxi57 80 1 This this DT cord-326673-p8qbxi57 80 2 suggests suggest VBZ cord-326673-p8qbxi57 80 3 that that IN cord-326673-p8qbxi57 80 4 the the DT cord-326673-p8qbxi57 80 5 duration duration NN cord-326673-p8qbxi57 80 6 of of IN cord-326673-p8qbxi57 80 7 the the DT cord-326673-p8qbxi57 80 8 interference interference NN cord-326673-p8qbxi57 80 9 of of IN cord-326673-p8qbxi57 80 10 MDA MDA NNP cord-326673-p8qbxi57 80 11 with with IN cord-326673-p8qbxi57 80 12 antibody antibody NN cord-326673-p8qbxi57 80 13 responses response NNS cord-326673-p8qbxi57 80 14 to to IN cord-326673-p8qbxi57 80 15 vaccines vaccine NNS cord-326673-p8qbxi57 80 16 may may MD cord-326673-p8qbxi57 80 17 be be VB cord-326673-p8qbxi57 80 18 specific specific JJ cord-326673-p8qbxi57 80 19 to to IN cord-326673-p8qbxi57 80 20 individual individual JJ cord-326673-p8qbxi57 80 21 protein protein NN cord-326673-p8qbxi57 80 22 sub sub NN cord-326673-p8qbxi57 80 23 - - HYPH cord-326673-p8qbxi57 80 24 units unit NNS cord-326673-p8qbxi57 80 25 or or CC cord-326673-p8qbxi57 80 26 even even RB cord-326673-p8qbxi57 80 27 epitopes epitope NNS cord-326673-p8qbxi57 81 1 ( ( -LRB- cord-326673-p8qbxi57 81 2 van van NNP cord-326673-p8qbxi57 81 3 Maanen Maanen NNP cord-326673-p8qbxi57 81 4 et et NNP cord-326673-p8qbxi57 81 5 al al NNP cord-326673-p8qbxi57 81 6 . . NNP cord-326673-p8qbxi57 81 7 , , , cord-326673-p8qbxi57 81 8 1992 1992 CD cord-326673-p8qbxi57 81 9 ) ) -RRB- cord-326673-p8qbxi57 81 10 , , , cord-326673-p8qbxi57 81 11 which which WDT cord-326673-p8qbxi57 81 12 emphasizes emphasize VBZ cord-326673-p8qbxi57 81 13 the the DT cord-326673-p8qbxi57 81 14 importance importance NN cord-326673-p8qbxi57 81 15 of of IN cord-326673-p8qbxi57 81 16 vaccine vaccine NN cord-326673-p8qbxi57 81 17 potency potency NN cord-326673-p8qbxi57 81 18 in in IN cord-326673-p8qbxi57 81 19 a a DT cord-326673-p8qbxi57 81 20 situation situation NN cord-326673-p8qbxi57 81 21 where where WRB cord-326673-p8qbxi57 81 22 high high JJ cord-326673-p8qbxi57 81 23 MDA MDA NNP cord-326673-p8qbxi57 81 24 titres titre NNS cord-326673-p8qbxi57 81 25 are be VBP cord-326673-p8qbxi57 81 26 present present JJ cord-326673-p8qbxi57 81 27 . . . cord-326673-p8qbxi57 82 1 In in IN cord-326673-p8qbxi57 82 2 support support NN cord-326673-p8qbxi57 82 3 of of IN cord-326673-p8qbxi57 82 4 this this DT cord-326673-p8qbxi57 82 5 hypothesis hypothesis NN cord-326673-p8qbxi57 82 6 that that DT cord-326673-p8qbxi57 82 7 interference interference NN cord-326673-p8qbxi57 82 8 by by IN cord-326673-p8qbxi57 82 9 MDA MDA NNP cord-326673-p8qbxi57 82 10 could could MD cord-326673-p8qbxi57 82 11 be be VB cord-326673-p8qbxi57 82 12 specific specific JJ cord-326673-p8qbxi57 82 13 to to IN cord-326673-p8qbxi57 82 14 particular particular JJ cord-326673-p8qbxi57 82 15 antigens antigen NNS cord-326673-p8qbxi57 82 16 are be VBP cord-326673-p8qbxi57 82 17 the the DT cord-326673-p8qbxi57 82 18 results result NNS cord-326673-p8qbxi57 82 19 of of IN cord-326673-p8qbxi57 82 20 Kit kit NN cord-326673-p8qbxi57 82 21 et et FW cord-326673-p8qbxi57 82 22 al al NNP cord-326673-p8qbxi57 82 23 . . . cord-326673-p8qbxi57 83 1 ( ( -LRB- cord-326673-p8qbxi57 83 2 1993 1993 CD cord-326673-p8qbxi57 83 3 ) ) -RRB- cord-326673-p8qbxi57 83 4 who who WP cord-326673-p8qbxi57 83 5 were be VBD cord-326673-p8qbxi57 83 6 able able JJ cord-326673-p8qbxi57 83 7 to to TO cord-326673-p8qbxi57 83 8 partially partially RB cord-326673-p8qbxi57 83 9 overcome overcome VB cord-326673-p8qbxi57 83 10 the the DT cord-326673-p8qbxi57 83 11 MDA MDA NNP cord-326673-p8qbxi57 83 12 to to IN cord-326673-p8qbxi57 83 13 pseudorabies pseudorabie NNS cord-326673-p8qbxi57 83 14 with with IN cord-326673-p8qbxi57 83 15 a a DT cord-326673-p8qbxi57 83 16 live live JJ cord-326673-p8qbxi57 83 17 glycoprotein glycoprotein NN cord-326673-p8qbxi57 83 18 glII glii NN cord-326673-p8qbxi57 83 19 - - HYPH cord-326673-p8qbxi57 83 20 deleted delete VBN cord-326673-p8qbxi57 83 21 marker marker NN cord-326673-p8qbxi57 83 22 vaccine vaccine NN cord-326673-p8qbxi57 83 23 . . . cord-326673-p8qbxi57 84 1 Ill ill JJ cord-326673-p8qbxi57 84 2 many many JJ cord-326673-p8qbxi57 84 3 of of IN cord-326673-p8qbxi57 84 4 the the DT cord-326673-p8qbxi57 84 5 FMD FMD NNP cord-326673-p8qbxi57 84 6 endemic endemic JJ cord-326673-p8qbxi57 84 7 regions region NNS cord-326673-p8qbxi57 84 8 of of IN cord-326673-p8qbxi57 84 9 the the DT cord-326673-p8qbxi57 84 10 world world NN cord-326673-p8qbxi57 84 11 cattle cattle NNS cord-326673-p8qbxi57 84 12 , , , cord-326673-p8qbxi57 84 13 and and CC cord-326673-p8qbxi57 84 14 sometimes sometimes RB cord-326673-p8qbxi57 84 15 also also RB cord-326673-p8qbxi57 84 16 pigs pig NNS cord-326673-p8qbxi57 84 17 , , , cord-326673-p8qbxi57 84 18 are be VBP cord-326673-p8qbxi57 84 19 vaccinated vaccinate VBN cord-326673-p8qbxi57 84 20 between between IN cord-326673-p8qbxi57 84 21 one one CD cord-326673-p8qbxi57 84 22 and and CC cord-326673-p8qbxi57 84 23 four four CD cord-326673-p8qbxi57 84 24 times time NNS cord-326673-p8qbxi57 84 25 a a DT cord-326673-p8qbxi57 84 26 year year NN cord-326673-p8qbxi57 84 27 , , , cord-326673-p8qbxi57 84 28 against against IN cord-326673-p8qbxi57 84 29 the the DT cord-326673-p8qbxi57 84 30 prevalent prevalent JJ cord-326673-p8qbxi57 84 31 serotypes serotype NNS cord-326673-p8qbxi57 84 32 of of IN cord-326673-p8qbxi57 84 33 FMD FMD NNP cord-326673-p8qbxi57 84 34 virus virus NN cord-326673-p8qbxi57 84 35 . . . cord-326673-p8qbxi57 85 1 The the DT cord-326673-p8qbxi57 85 2 half half JJ cord-326673-p8qbxi57 85 3 - - HYPH cord-326673-p8qbxi57 85 4 life life NN cord-326673-p8qbxi57 85 5 of of IN cord-326673-p8qbxi57 85 6 MDA MDA NNP cord-326673-p8qbxi57 85 7 to to IN cord-326673-p8qbxi57 85 8 FMD FMD NNP cord-326673-p8qbxi57 85 9 virus virus NN cord-326673-p8qbxi57 85 10 in in IN cord-326673-p8qbxi57 85 11 the the DT cord-326673-p8qbxi57 85 12 calf calf NN cord-326673-p8qbxi57 85 13 is be VBZ cord-326673-p8qbxi57 85 14 approximately approximately RB cord-326673-p8qbxi57 85 15 22 22 CD cord-326673-p8qbxi57 85 16 days day NNS cord-326673-p8qbxi57 85 17 ( ( -LRB- cord-326673-p8qbxi57 86 1 Nicholls Nicholls NNP cord-326673-p8qbxi57 86 2 et et NNP cord-326673-p8qbxi57 86 3 al al NNP cord-326673-p8qbxi57 86 4 . . NNP cord-326673-p8qbxi57 86 5 , , , cord-326673-p8qbxi57 86 6 1984 1984 CD cord-326673-p8qbxi57 86 7 ) ) -RRB- cord-326673-p8qbxi57 86 8 and and CC cord-326673-p8qbxi57 86 9 21 21 CD cord-326673-p8qbxi57 86 10 days day NNS cord-326673-p8qbxi57 86 11 in in IN cord-326673-p8qbxi57 86 12 the the DT cord-326673-p8qbxi57 86 13 pig pig NN cord-326673-p8qbxi57 86 14 ( ( -LRB- cord-326673-p8qbxi57 86 15 Francis Francis NNP cord-326673-p8qbxi57 86 16 & & CC cord-326673-p8qbxi57 86 17 Black Black NNP cord-326673-p8qbxi57 86 18 , , , cord-326673-p8qbxi57 86 19 1984 1984 CD cord-326673-p8qbxi57 86 20 ) ) -RRB- cord-326673-p8qbxi57 86 21 , , , cord-326673-p8qbxi57 86 22 although although IN cord-326673-p8qbxi57 86 23 in in IN cord-326673-p8qbxi57 86 24 the the DT cord-326673-p8qbxi57 86 25 pig pig NN cord-326673-p8qbxi57 86 26 the the DT cord-326673-p8qbxi57 86 27 decline decline NN cord-326673-p8qbxi57 86 28 in in IN cord-326673-p8qbxi57 86 29 concentration concentration NN cord-326673-p8qbxi57 86 30 was be VBD cord-326673-p8qbxi57 86 31 considered consider VBN cord-326673-p8qbxi57 86 32 to to TO cord-326673-p8qbxi57 86 33 be be VB cord-326673-p8qbxi57 86 34 due due RB cord-326673-p8qbxi57 86 35 more more JJR cord-326673-p8qbxi57 86 36 to to IN cord-326673-p8qbxi57 86 37 the the DT cord-326673-p8qbxi57 86 38 increase increase NN cord-326673-p8qbxi57 86 39 in in IN cord-326673-p8qbxi57 86 40 body body NN cord-326673-p8qbxi57 86 41 weight weight NN cord-326673-p8qbxi57 86 42 than than IN cord-326673-p8qbxi57 86 43 degradation degradation NN cord-326673-p8qbxi57 86 44 or or CC cord-326673-p8qbxi57 86 45 excretion excretion NN cord-326673-p8qbxi57 86 46 of of IN cord-326673-p8qbxi57 86 47 the the DT cord-326673-p8qbxi57 86 48 MDA MDA NNP cord-326673-p8qbxi57 86 49 . . . cord-326673-p8qbxi57 87 1 The the DT cord-326673-p8qbxi57 87 2 initial initial JJ cord-326673-p8qbxi57 87 3 blood blood NN cord-326673-p8qbxi57 87 4 level level NN cord-326673-p8qbxi57 87 5 of of IN cord-326673-p8qbxi57 87 6 MDA MDA NNP cord-326673-p8qbxi57 87 7 and and CC cord-326673-p8qbxi57 87 8 its -PRON- PRP$ cord-326673-p8qbxi57 87 9 subsequent subsequent JJ cord-326673-p8qbxi57 87 10 persistence persistence NN cord-326673-p8qbxi57 87 11 relates relate VBZ cord-326673-p8qbxi57 87 12 directly directly RB cord-326673-p8qbxi57 87 13 to to IN cord-326673-p8qbxi57 87 14 its -PRON- PRP$ cord-326673-p8qbxi57 87 15 level level NN cord-326673-p8qbxi57 87 16 in in IN cord-326673-p8qbxi57 87 17 the the DT cord-326673-p8qbxi57 87 18 colostrum colostrum NN cord-326673-p8qbxi57 87 19 and and CC cord-326673-p8qbxi57 87 20 the the DT cord-326673-p8qbxi57 87 21 efficiency efficiency NN cord-326673-p8qbxi57 87 22 with with IN cord-326673-p8qbxi57 87 23 which which WDT cord-326673-p8qbxi57 87 24 it -PRON- PRP cord-326673-p8qbxi57 87 25 is be VBZ cord-326673-p8qbxi57 87 26 adsorbed adsorb VBN cord-326673-p8qbxi57 87 27 . . . cord-326673-p8qbxi57 88 1 Heifers heifer NNS cord-326673-p8qbxi57 88 2 tend tend VBP cord-326673-p8qbxi57 88 3 to to TO cord-326673-p8qbxi57 88 4 have have VB cord-326673-p8qbxi57 88 5 lower low JJR cord-326673-p8qbxi57 88 6 levels level NNS cord-326673-p8qbxi57 88 7 of of IN cord-326673-p8qbxi57 88 8 specific specific JJ cord-326673-p8qbxi57 88 9 anti anti JJ cord-326673-p8qbxi57 88 10 - - JJ cord-326673-p8qbxi57 88 11 FMD FMD NNP cord-326673-p8qbxi57 88 12 virus virus NN cord-326673-p8qbxi57 88 13 antibody antibody NN cord-326673-p8qbxi57 88 14 in in IN cord-326673-p8qbxi57 88 15 their -PRON- PRP$ cord-326673-p8qbxi57 88 16 colostrum colostrum NN cord-326673-p8qbxi57 88 17 than than IN cord-326673-p8qbxi57 88 18 adult adult NN cord-326673-p8qbxi57 88 19 cows cow NNS cord-326673-p8qbxi57 88 20 , , , cord-326673-p8qbxi57 88 21 and and CC cord-326673-p8qbxi57 88 22 consequently consequently RB cord-326673-p8qbxi57 88 23 their -PRON- PRP$ cord-326673-p8qbxi57 88 24 calves calf NNS cord-326673-p8qbxi57 88 25 receive receive VBP cord-326673-p8qbxi57 88 26 lower low JJR cord-326673-p8qbxi57 88 27 quantities quantity NNS cord-326673-p8qbxi57 88 28 of of IN cord-326673-p8qbxi57 88 29 specific specific JJ cord-326673-p8qbxi57 88 30 antibody antibody NN cord-326673-p8qbxi57 88 31 than than IN cord-326673-p8qbxi57 88 32 the the DT cord-326673-p8qbxi57 88 33 calves calf NNS cord-326673-p8qbxi57 88 34 of of IN cord-326673-p8qbxi57 88 35 second second JJ cord-326673-p8qbxi57 88 36 or or CC cord-326673-p8qbxi57 88 37 third third JJ cord-326673-p8qbxi57 88 38 lactation lactation NN cord-326673-p8qbxi57 88 39 cows cow NNS cord-326673-p8qbxi57 88 40 . . . cord-326673-p8qbxi57 89 1 This this DT cord-326673-p8qbxi57 89 2 can can MD cord-326673-p8qbxi57 89 3 result result VB cord-326673-p8qbxi57 89 4 in in IN cord-326673-p8qbxi57 89 5 an an DT cord-326673-p8qbxi57 89 6 earlier early JJR cord-326673-p8qbxi57 89 7 susceptibility susceptibility NN cord-326673-p8qbxi57 89 8 to to IN cord-326673-p8qbxi57 89 9 FMD fmd NN cord-326673-p8qbxi57 89 10 infection infection NN cord-326673-p8qbxi57 89 11 in in IN cord-326673-p8qbxi57 89 12 endemic endemic JJ cord-326673-p8qbxi57 89 13 situations situation NNS cord-326673-p8qbxi57 89 14 , , , cord-326673-p8qbxi57 89 15 and and CC cord-326673-p8qbxi57 89 16 makes make VBZ cord-326673-p8qbxi57 89 17 it -PRON- PRP cord-326673-p8qbxi57 89 18 more more RBR cord-326673-p8qbxi57 89 19 difficult difficult JJ cord-326673-p8qbxi57 89 20 to to TO cord-326673-p8qbxi57 89 21 formulate formulate VB cord-326673-p8qbxi57 89 22 vaccination vaccination NN cord-326673-p8qbxi57 89 23 schedules schedule NNS cord-326673-p8qbxi57 89 24 . . . cord-326673-p8qbxi57 90 1 In in IN cord-326673-p8qbxi57 90 2 South South NNP cord-326673-p8qbxi57 90 3 America America NNP cord-326673-p8qbxi57 90 4 , , , cord-326673-p8qbxi57 90 5 Nicholls Nicholls NNP cord-326673-p8qbxi57 90 6 el el NNP cord-326673-p8qbxi57 90 7 al al NNP cord-326673-p8qbxi57 90 8 . . . cord-326673-p8qbxi57 91 1 ( ( -LRB- cord-326673-p8qbxi57 91 2 1984 1984 CD cord-326673-p8qbxi57 91 3 ) ) -RRB- cord-326673-p8qbxi57 91 4 showed show VBD cord-326673-p8qbxi57 91 5 that that IN cord-326673-p8qbxi57 91 6 MDA MDA NNP cord-326673-p8qbxi57 91 7 against against IN cord-326673-p8qbxi57 91 8 FMD FMD NNP cord-326673-p8qbxi57 91 9 was be VBD cord-326673-p8qbxi57 91 10 likely likely JJ cord-326673-p8qbxi57 91 11 to to TO cord-326673-p8qbxi57 91 12 persist persist VB cord-326673-p8qbxi57 91 13 for for IN cord-326673-p8qbxi57 91 14 4 4 CD cord-326673-p8qbxi57 91 15 - - SYM cord-326673-p8qbxi57 91 16 5 5 CD cord-326673-p8qbxi57 91 17 months month NNS cord-326673-p8qbxi57 91 18 , , , cord-326673-p8qbxi57 91 19 and and CC cord-326673-p8qbxi57 91 20 that that IN cord-326673-p8qbxi57 91 21 calves calf NNS cord-326673-p8qbxi57 91 22 with with IN cord-326673-p8qbxi57 91 23 MDA MDA NNP cord-326673-p8qbxi57 91 24 vaccinated vaccinate VBD cord-326673-p8qbxi57 91 25 against against IN cord-326673-p8qbxi57 91 26 FMD FMD NNP cord-326673-p8qbxi57 91 27 not not RB cord-326673-p8qbxi57 91 28 only only RB cord-326673-p8qbxi57 91 29 failed fail VBD cord-326673-p8qbxi57 91 30 to to TO cord-326673-p8qbxi57 91 31 respond respond VB cord-326673-p8qbxi57 91 32 , , , cord-326673-p8qbxi57 91 33 but but CC cord-326673-p8qbxi57 91 34 that that DT cord-326673-p8qbxi57 91 35 vaccination vaccination NN cord-326673-p8qbxi57 91 36 depressed depress VBD cord-326673-p8qbxi57 91 37 the the DT cord-326673-p8qbxi57 91 38 serum serum NN cord-326673-p8qbxi57 91 39 titre titre NN cord-326673-p8qbxi57 91 40 of of IN cord-326673-p8qbxi57 91 41 specific specific JJ cord-326673-p8qbxi57 91 42 FMD FMD NNP cord-326673-p8qbxi57 91 43 virus virus NN cord-326673-p8qbxi57 91 44 antibody antibody NN cord-326673-p8qbxi57 91 45 in in IN cord-326673-p8qbxi57 91 46 these these DT cord-326673-p8qbxi57 91 47 animals animal NNS cord-326673-p8qbxi57 91 48 . . . cord-326673-p8qbxi57 92 1 They -PRON- PRP cord-326673-p8qbxi57 92 2 recommended recommend VBD cord-326673-p8qbxi57 92 3 that that IN cord-326673-p8qbxi57 92 4 calves calf NNS cord-326673-p8qbxi57 92 5 receive receive VBP cord-326673-p8qbxi57 92 6 their -PRON- PRP$ cord-326673-p8qbxi57 92 7 prima prima NN cord-326673-p8qbxi57 92 8 W W NNP cord-326673-p8qbxi57 92 9 vaccination vaccination NN cord-326673-p8qbxi57 92 10 at at IN cord-326673-p8qbxi57 92 11 5 5 CD cord-326673-p8qbxi57 92 12 - - SYM cord-326673-p8qbxi57 92 13 6 6 CD cord-326673-p8qbxi57 92 14 months month NNS cord-326673-p8qbxi57 92 15 of of IN cord-326673-p8qbxi57 92 16 age age NN cord-326673-p8qbxi57 92 17 . . . cord-326673-p8qbxi57 93 1 A a DT cord-326673-p8qbxi57 93 2 similar similar JJ cord-326673-p8qbxi57 93 3 situation situation NN cord-326673-p8qbxi57 93 4 exists exist VBZ cord-326673-p8qbxi57 93 5 in in IN cord-326673-p8qbxi57 93 6 the the DT cord-326673-p8qbxi57 93 7 large large JJ cord-326673-p8qbxi57 93 8 dairy dairy NN cord-326673-p8qbxi57 93 9 herds herd NNS cord-326673-p8qbxi57 93 10 in in IN cord-326673-p8qbxi57 93 11 the the DT cord-326673-p8qbxi57 93 12 Middle Middle NNP cord-326673-p8qbxi57 93 13 East East NNP cord-326673-p8qbxi57 93 14 ( ( -LRB- cord-326673-p8qbxi57 93 15 Kitching Kitching NNP cord-326673-p8qbxi57 93 16 , , , cord-326673-p8qbxi57 93 17 unpublished unpublished JJ cord-326673-p8qbxi57 93 18 observations observation NNS cord-326673-p8qbxi57 93 19 ) ) -RRB- cord-326673-p8qbxi57 93 20 . . . cord-326673-p8qbxi57 94 1 High high JJ cord-326673-p8qbxi57 94 2 yielding yield VBG cord-326673-p8qbxi57 94 3 dairy dairy NN cord-326673-p8qbxi57 94 4 cows cow NNS cord-326673-p8qbxi57 94 5 have have VBP cord-326673-p8qbxi57 94 6 been be VBN cord-326673-p8qbxi57 94 7 imported import VBN cord-326673-p8qbxi57 94 8 from from IN cord-326673-p8qbxi57 94 9 Europe Europe NNP cord-326673-p8qbxi57 94 10 and and CC cord-326673-p8qbxi57 94 11 North North NNP cord-326673-p8qbxi57 94 12 America America NNP cord-326673-p8qbxi57 94 13 into into IN cord-326673-p8qbxi57 94 14 a a DT cord-326673-p8qbxi57 94 15 hostile hostile JJ cord-326673-p8qbxi57 94 16 climate climate NN cord-326673-p8qbxi57 94 17 and and CC cord-326673-p8qbxi57 94 18 an an DT cord-326673-p8qbxi57 94 19 environment environment NN cord-326673-p8qbxi57 94 20 in in IN cord-326673-p8qbxi57 94 21 which which WDT cord-326673-p8qbxi57 94 22 previously previously RB cord-326673-p8qbxi57 94 23 unencountered unencountered JJ cord-326673-p8qbxi57 94 24 disease disease NN cord-326673-p8qbxi57 94 25 such such JJ cord-326673-p8qbxi57 94 26 as as IN cord-326673-p8qbxi57 94 27 FMD FMD NNP cord-326673-p8qbxi57 94 28 and and CC cord-326673-p8qbxi57 94 29 rinderpest rinderpest NN cord-326673-p8qbxi57 94 30 are be VBP cord-326673-p8qbxi57 94 31 endemic endemic JJ cord-326673-p8qbxi57 94 32 . . . cord-326673-p8qbxi57 95 1 Clinical clinical JJ cord-326673-p8qbxi57 95 2 FMD FMD NNP cord-326673-p8qbxi57 95 3 is be VBZ cord-326673-p8qbxi57 95 4 kept keep VBN cord-326673-p8qbxi57 95 5 under under IN cord-326673-p8qbxi57 95 6 control control NN cord-326673-p8qbxi57 95 7 by by IN cord-326673-p8qbxi57 95 8 three three CD cord-326673-p8qbxi57 95 9 or or CC cord-326673-p8qbxi57 95 10 four four CD cord-326673-p8qbxi57 95 11 times time NNS cord-326673-p8qbxi57 95 12 a a DT cord-326673-p8qbxi57 95 13 year year NN cord-326673-p8qbxi57 95 14 vaccination vaccination NN cord-326673-p8qbxi57 95 15 , , , cord-326673-p8qbxi57 95 16 but but CC cord-326673-p8qbxi57 95 17 frequently frequently RB cord-326673-p8qbxi57 95 18 it -PRON- PRP cord-326673-p8qbxi57 95 19 is be VBZ cord-326673-p8qbxi57 95 20 the the DT cord-326673-p8qbxi57 95 21 6 6 CD cord-326673-p8qbxi57 95 22 - - SYM cord-326673-p8qbxi57 95 23 18 18 CD cord-326673-p8qbxi57 95 24 month month NN cord-326673-p8qbxi57 95 25 age age NN cord-326673-p8qbxi57 95 26 group group NN cord-326673-p8qbxi57 95 27 which which WDT cord-326673-p8qbxi57 95 28 develops develop VBZ cord-326673-p8qbxi57 95 29 disease disease NN cord-326673-p8qbxi57 95 30 in in IN cord-326673-p8qbxi57 95 31 spite spite NN cord-326673-p8qbxi57 95 32 of of IN cord-326673-p8qbxi57 95 33 this this DT cord-326673-p8qbxi57 95 34 vaccination vaccination NN cord-326673-p8qbxi57 95 35 regime regime NN cord-326673-p8qbxi57 95 36 . . . cord-326673-p8qbxi57 96 1 Many many JJ cord-326673-p8qbxi57 96 2 farm farm NN cord-326673-p8qbxi57 96 3 managers manager NNS cord-326673-p8qbxi57 96 4 had have VBD cord-326673-p8qbxi57 96 5 become become VBN cord-326673-p8qbxi57 96 6 frustrated frustrate VBN cord-326673-p8qbxi57 96 7 by by IN cord-326673-p8qbxi57 96 8 the the DT cord-326673-p8qbxi57 96 9 apparent apparent JJ cord-326673-p8qbxi57 96 10 ineffectiveness ineffectiveness NN cord-326673-p8qbxi57 96 11 of of IN cord-326673-p8qbxi57 96 12 the the DT cord-326673-p8qbxi57 96 13 FMD FMD NNP cord-326673-p8qbxi57 96 14 vaccine vaccine NN cord-326673-p8qbxi57 96 15 , , , cord-326673-p8qbxi57 96 16 whereby whereby WRB cord-326673-p8qbxi57 96 17 they -PRON- PRP cord-326673-p8qbxi57 96 18 had have VBD cord-326673-p8qbxi57 96 19 been be VBN cord-326673-p8qbxi57 96 20 using use VBG cord-326673-p8qbxi57 96 21 a a DT cord-326673-p8qbxi57 96 22 variety variety NN cord-326673-p8qbxi57 96 23 of of IN cord-326673-p8qbxi57 96 24 calfhood calfhood NN cord-326673-p8qbxi57 96 25 vaccination vaccination NN cord-326673-p8qbxi57 96 26 protocols protocol NNS cord-326673-p8qbxi57 96 27 , , , cord-326673-p8qbxi57 96 28 almost almost RB cord-326673-p8qbxi57 96 29 all all DT cord-326673-p8qbxi57 96 30 of of IN cord-326673-p8qbxi57 96 31 which which WDT cord-326673-p8qbxi57 96 32 initiated initiate VBD cord-326673-p8qbxi57 96 33 vaccination vaccination NN cord-326673-p8qbxi57 96 34 before before IN cord-326673-p8qbxi57 96 35 3 3 CD cord-326673-p8qbxi57 96 36 months month NNS cord-326673-p8qbxi57 96 37 of of IN cord-326673-p8qbxi57 96 38 age age NN cord-326673-p8qbxi57 96 39 , , , cord-326673-p8qbxi57 96 40 and and CC cord-326673-p8qbxi57 96 41 in in IN cord-326673-p8qbxi57 96 42 some some DT cord-326673-p8qbxi57 96 43 instances instance NNS cord-326673-p8qbxi57 96 44 as as RB cord-326673-p8qbxi57 96 45 early early RB cord-326673-p8qbxi57 96 46 as as IN cord-326673-p8qbxi57 96 47 1 1 CD cord-326673-p8qbxi57 96 48 day day NN cord-326673-p8qbxi57 96 49 old old JJ cord-326673-p8qbxi57 96 50 . . . cord-326673-p8qbxi57 97 1 The the DT cord-326673-p8qbxi57 97 2 reason reason NN cord-326673-p8qbxi57 97 3 for for IN cord-326673-p8qbxi57 97 4 the the DT cord-326673-p8qbxi57 97 5 vac vac NN cord-326673-p8qbxi57 97 6 - - HYPH cord-326673-p8qbxi57 97 7 cine cine JJ cord-326673-p8qbxi57 97 8 failure failure NN cord-326673-p8qbxi57 97 9 was be VBD cord-326673-p8qbxi57 97 10 tile tile NN cord-326673-p8qbxi57 97 11 same same JJ cord-326673-p8qbxi57 97 12 as as IN cord-326673-p8qbxi57 97 13 had have VBD cord-326673-p8qbxi57 97 14 been be VBN cord-326673-p8qbxi57 97 15 shown show VBN cord-326673-p8qbxi57 97 16 in in IN cord-326673-p8qbxi57 97 17 South South NNP cord-326673-p8qbxi57 97 18 America America NNP cord-326673-p8qbxi57 97 19 a a DT cord-326673-p8qbxi57 97 20 decade decade NN cord-326673-p8qbxi57 97 21 earlier early RBR cord-326673-p8qbxi57 97 22 , , , cord-326673-p8qbxi57 97 23 except except IN cord-326673-p8qbxi57 97 24 in in IN cord-326673-p8qbxi57 97 25 the the DT cord-326673-p8qbxi57 97 26 Middle Middle NNP cord-326673-p8qbxi57 97 27 East East NNP cord-326673-p8qbxi57 97 28 the the DT cord-326673-p8qbxi57 97 29 cows cow NNS cord-326673-p8qbxi57 97 30 were be VBD cord-326673-p8qbxi57 97 31 being be VBG cord-326673-p8qbxi57 97 32 vaccinated vaccinate VBN cord-326673-p8qbxi57 97 33 far far RB cord-326673-p8qbxi57 97 34 more more RBR cord-326673-p8qbxi57 97 35 frequently frequently RB cord-326673-p8qbxi57 97 36 and and CC cord-326673-p8qbxi57 97 37 efficiently efficiently RB cord-326673-p8qbxi57 97 38 and and CC cord-326673-p8qbxi57 97 39 the the DT cord-326673-p8qbxi57 97 40 MDA MDA NNP cord-326673-p8qbxi57 97 41 in in IN cord-326673-p8qbxi57 97 42 their -PRON- PRP$ cord-326673-p8qbxi57 97 43 calves calf NNS cord-326673-p8qbxi57 97 44 was be VBD cord-326673-p8qbxi57 97 45 at at IN cord-326673-p8qbxi57 97 46 a a DT cord-326673-p8qbxi57 97 47 very very RB cord-326673-p8qbxi57 97 48 high high JJ cord-326673-p8qbxi57 97 49 level level NN cord-326673-p8qbxi57 97 50 . . . cord-326673-p8qbxi57 98 1 The the DT cord-326673-p8qbxi57 98 2 calves calf NNS cord-326673-p8qbxi57 98 3 were be VBD cord-326673-p8qbxi57 98 4 reaching reach VBG cord-326673-p8qbxi57 98 5 the the DT cord-326673-p8qbxi57 98 6 age age NN cord-326673-p8qbxi57 98 7 of of IN cord-326673-p8qbxi57 98 8 5 5 CD cord-326673-p8qbxi57 98 9 or or CC cord-326673-p8qbxi57 98 10 6 6 CD cord-326673-p8qbxi57 98 11 months month NNS cord-326673-p8qbxi57 98 12 , , , cord-326673-p8qbxi57 98 13 by by IN cord-326673-p8qbxi57 98 14 which which WDT cord-326673-p8qbxi57 98 15 time time NN cord-326673-p8qbxi57 98 16 they -PRON- PRP cord-326673-p8qbxi57 98 17 had have VBD cord-326673-p8qbxi57 98 18 received receive VBN cord-326673-p8qbxi57 98 19 at at IN cord-326673-p8qbxi57 98 20 least least RBS cord-326673-p8qbxi57 98 21 two two CD cord-326673-p8qbxi57 98 22 ineffective ineffective JJ cord-326673-p8qbxi57 98 23 vaccinations vaccination NNS cord-326673-p8qbxi57 98 24 because because IN cord-326673-p8qbxi57 98 25 of of IN cord-326673-p8qbxi57 98 26 the the DT cord-326673-p8qbxi57 98 27 MDA MDA NNP cord-326673-p8qbxi57 98 28 , , , cord-326673-p8qbxi57 98 29 and and CC cord-326673-p8qbxi57 98 30 were be VBD cord-326673-p8qbxi57 98 31 then then RB cord-326673-p8qbxi57 98 32 becoming become VBG cord-326673-p8qbxi57 98 33 susceptible susceptible JJ cord-326673-p8qbxi57 98 34 to to IN cord-326673-p8qbxi57 98 35 infection infection NN cord-326673-p8qbxi57 98 36 with with IN cord-326673-p8qbxi57 98 37 FMD FMD NNP cord-326673-p8qbxi57 98 38 virus virus NN cord-326673-p8qbxi57 98 39 . . . cord-326673-p8qbxi57 99 1 To to TO cord-326673-p8qbxi57 99 2 compound compound VB cord-326673-p8qbxi57 99 3 the the DT cord-326673-p8qbxi57 99 4 problem problem NN cord-326673-p8qbxi57 99 5 , , , cord-326673-p8qbxi57 99 6 if if IN cord-326673-p8qbxi57 99 7 the the DT cord-326673-p8qbxi57 99 8 calves calf NNS cord-326673-p8qbxi57 99 9 developed develop VBD cord-326673-p8qbxi57 99 10 clinical clinical JJ cord-326673-p8qbxi57 99 11 FMD FMD NNP cord-326673-p8qbxi57 99 12 , , , cord-326673-p8qbxi57 99 13 the the DT cord-326673-p8qbxi57 99 14 environmental environmental JJ cord-326673-p8qbxi57 99 15 shedding shedding NN cord-326673-p8qbxi57 99 16 of of IN cord-326673-p8qbxi57 99 17 virus virus NN cord-326673-p8qbxi57 99 18 from from IN cord-326673-p8qbxi57 99 19 these these DT cord-326673-p8qbxi57 99 20 calves calf NNS cord-326673-p8qbxi57 99 21 was be VBD cord-326673-p8qbxi57 99 22 frequently frequently RB cord-326673-p8qbxi57 99 23 sufficient sufficient JJ cord-326673-p8qbxi57 99 24 to to TO cord-326673-p8qbxi57 99 25 overcome overcome VB cord-326673-p8qbxi57 99 26 the the DT cord-326673-p8qbxi57 99 27 immunity immunity NN cord-326673-p8qbxi57 99 28 of of IN cord-326673-p8qbxi57 99 29 other other JJ cord-326673-p8qbxi57 99 30 animals animal NNS cord-326673-p8qbxi57 99 31 on on IN cord-326673-p8qbxi57 99 32 the the DT cord-326673-p8qbxi57 99 33 farm farm NN cord-326673-p8qbxi57 99 34 , , , cord-326673-p8qbxi57 99 35 resulting result VBG cord-326673-p8qbxi57 99 36 in in IN cord-326673-p8qbxi57 99 37 a a DT cord-326673-p8qbxi57 99 38 major major JJ cord-326673-p8qbxi57 99 39 outbreak outbreak NN cord-326673-p8qbxi57 99 40 and and CC cord-326673-p8qbxi57 99 41 loss loss NN cord-326673-p8qbxi57 99 42 of of IN cord-326673-p8qbxi57 99 43 production production NN cord-326673-p8qbxi57 99 44 from from IN cord-326673-p8qbxi57 99 45 the the DT cord-326673-p8qbxi57 99 46 milking milking NN cord-326673-p8qbxi57 99 47 herd herd NN cord-326673-p8qbxi57 99 48 . . . cord-326673-p8qbxi57 100 1 A a DT cord-326673-p8qbxi57 100 2 study study NN cord-326673-p8qbxi57 100 3 was be VBD cord-326673-p8qbxi57 100 4 undertaken undertake VBN cord-326673-p8qbxi57 100 5 in in IN cord-326673-p8qbxi57 100 6 which which WDT cord-326673-p8qbxi57 100 7 a a DT cord-326673-p8qbxi57 100 8 number number NN cord-326673-p8qbxi57 100 9 of of IN cord-326673-p8qbxi57 100 10 the the DT cord-326673-p8qbxi57 100 11 larger large JJR cord-326673-p8qbxi57 100 12 dairy dairy NN cord-326673-p8qbxi57 100 13 herds herd NNS cord-326673-p8qbxi57 100 14 participated participate VBD cord-326673-p8qbxi57 100 15 , , , cord-326673-p8qbxi57 100 16 to to TO cord-326673-p8qbxi57 100 17 examine examine VB cord-326673-p8qbxi57 100 18 different different JJ cord-326673-p8qbxi57 100 19 calfllood calfllood NN cord-326673-p8qbxi57 100 20 vaccination vaccination NN cord-326673-p8qbxi57 100 21 programlnes programlne NNS cord-326673-p8qbxi57 100 22 . . . cord-326673-p8qbxi57 101 1 The the DT cord-326673-p8qbxi57 101 2 results result NNS cord-326673-p8qbxi57 101 3 of of IN cord-326673-p8qbxi57 101 4 this this DT cord-326673-p8qbxi57 101 5 previously previously RB cord-326673-p8qbxi57 101 6 unpublished unpublished JJ cord-326673-p8qbxi57 101 7 study study NN cord-326673-p8qbxi57 101 8 support support NN cord-326673-p8qbxi57 101 9 many many JJ cord-326673-p8qbxi57 101 10 of of IN cord-326673-p8qbxi57 101 11 the the DT cord-326673-p8qbxi57 101 12 conclusions conclusion NNS cord-326673-p8qbxi57 101 13 reached reach VBN cord-326673-p8qbxi57 101 14 by by IN cord-326673-p8qbxi57 101 15 Nicholls Nicholls NNP cord-326673-p8qbxi57 101 16 et et NNP cord-326673-p8qbxi57 101 17 aL aL NNP cord-326673-p8qbxi57 101 18 , , , cord-326673-p8qbxi57 102 1 ( ( -LRB- cord-326673-p8qbxi57 102 2 1984 1984 CD cord-326673-p8qbxi57 102 3 Nicholls Nicholls NNP cord-326673-p8qbxi57 102 4 et et NNP cord-326673-p8qbxi57 102 5 aL aL NNP cord-326673-p8qbxi57 102 6 , , , cord-326673-p8qbxi57 102 7 ( ( -LRB- cord-326673-p8qbxi57 102 8 , , , cord-326673-p8qbxi57 102 9 1985 1985 CD cord-326673-p8qbxi57 102 10 , , , cord-326673-p8qbxi57 103 1 but but CC cord-326673-p8qbxi57 103 2 in in IN cord-326673-p8qbxi57 103 3 addition addition NN cord-326673-p8qbxi57 103 4 addressed address VBD cord-326673-p8qbxi57 103 5 some some DT cord-326673-p8qbxi57 103 6 of of IN cord-326673-p8qbxi57 103 7 the the DT cord-326673-p8qbxi57 103 8 problems problem NNS cord-326673-p8qbxi57 103 9 more more RBR cord-326673-p8qbxi57 103 10 relevant relevant JJ cord-326673-p8qbxi57 103 11 to to IN cord-326673-p8qbxi57 103 12 the the DT cord-326673-p8qbxi57 103 13 Middle Middle NNP cord-326673-p8qbxi57 103 14 East East NNP cord-326673-p8qbxi57 103 15 situation situation NN cord-326673-p8qbxi57 103 16 . . . cord-326673-p8qbxi57 104 1 Assuming assume VBG cord-326673-p8qbxi57 104 2 the the DT cord-326673-p8qbxi57 104 3 level level NN cord-326673-p8qbxi57 104 4 of of IN cord-326673-p8qbxi57 104 5 management management NN cord-326673-p8qbxi57 104 6 was be VBD cord-326673-p8qbxi57 104 7 sufficient sufficient JJ cord-326673-p8qbxi57 104 8 to to TO cord-326673-p8qbxi57 104 9 ensure ensure VB cord-326673-p8qbxi57 104 10 that that IN cord-326673-p8qbxi57 104 11 all all DT cord-326673-p8qbxi57 104 12 calves calf NNS cord-326673-p8qbxi57 104 13 received receive VBD cord-326673-p8qbxi57 104 14 adequate adequate JJ cord-326673-p8qbxi57 104 15 colostrum colostrum NN cord-326673-p8qbxi57 104 16 , , , cord-326673-p8qbxi57 104 17 preferably preferably RB cord-326673-p8qbxi57 104 18 pooled pool VBD cord-326673-p8qbxi57 104 19 colostrum colostrum NN cord-326673-p8qbxi57 104 20 to to TO cord-326673-p8qbxi57 104 21 include include VB cord-326673-p8qbxi57 104 22 colosu'um colosu'um NNP cord-326673-p8qbxi57 104 23 from from IN cord-326673-p8qbxi57 104 24 older old JJR cord-326673-p8qbxi57 104 25 cows cow NNS cord-326673-p8qbxi57 104 26 , , , cord-326673-p8qbxi57 104 27 vaccination vaccination NN cord-326673-p8qbxi57 104 28 at at IN cord-326673-p8qbxi57 104 29 1 1 CD cord-326673-p8qbxi57 104 30 day day NN cord-326673-p8qbxi57 104 31 old old JJ cord-326673-p8qbxi57 104 32 or or CC cord-326673-p8qbxi57 104 33 1 1 CD cord-326673-p8qbxi57 104 34 month month NN cord-326673-p8qbxi57 104 35 of of IN cord-326673-p8qbxi57 104 36 age age NN cord-326673-p8qbxi57 104 37 , , , cord-326673-p8qbxi57 104 38 even even RB cord-326673-p8qbxi57 104 39 if if IN cord-326673-p8qbxi57 104 40 it -PRON- PRP cord-326673-p8qbxi57 104 41 was be VBD cord-326673-p8qbxi57 104 42 followed follow VBN cord-326673-p8qbxi57 104 43 by by IN cord-326673-p8qbxi57 104 44 a a DT cord-326673-p8qbxi57 104 45 booster booster NN cord-326673-p8qbxi57 104 46 vaccination vaccination NN cord-326673-p8qbxi57 104 47 at at IN cord-326673-p8qbxi57 104 48 21 21 CD cord-326673-p8qbxi57 104 49 days day NNS cord-326673-p8qbxi57 104 50 old old JJ cord-326673-p8qbxi57 104 51 or or CC cord-326673-p8qbxi57 104 52 2 2 CD cord-326673-p8qbxi57 104 53 months month NNS cord-326673-p8qbxi57 104 54 of of IN cord-326673-p8qbxi57 104 55 age age NN cord-326673-p8qbxi57 104 56 , , , cord-326673-p8qbxi57 104 57 respectively respectively RB cord-326673-p8qbxi57 104 58 , , , cord-326673-p8qbxi57 104 59 was be VBD cord-326673-p8qbxi57 104 60 ineffective ineffective JJ cord-326673-p8qbxi57 104 61 . . . cord-326673-p8qbxi57 105 1 It -PRON- PRP cord-326673-p8qbxi57 105 2 could could MD cord-326673-p8qbxi57 105 3 not not RB cord-326673-p8qbxi57 105 4 be be VB cord-326673-p8qbxi57 105 5 shown show VBN cord-326673-p8qbxi57 105 6 , , , cord-326673-p8qbxi57 105 7 however however RB cord-326673-p8qbxi57 105 8 , , , cord-326673-p8qbxi57 105 9 that that DT cord-326673-p8qbxi57 105 10 vaccination vaccination NN cord-326673-p8qbxi57 105 11 at at IN cord-326673-p8qbxi57 105 12 these these DT cord-326673-p8qbxi57 105 13 ages age NNS cord-326673-p8qbxi57 105 14 reduced reduce VBD cord-326673-p8qbxi57 105 15 the the DT cord-326673-p8qbxi57 105 16 level level NN cord-326673-p8qbxi57 105 17 of of IN cord-326673-p8qbxi57 105 18 circulating circulate VBG cord-326673-p8qbxi57 105 19 antibody antibody NN cord-326673-p8qbxi57 105 20 against against IN cord-326673-p8qbxi57 105 21 FMD FMD NNP cord-326673-p8qbxi57 105 22 virus virus NN cord-326673-p8qbxi57 105 23 in in IN cord-326673-p8qbxi57 105 24 calves calf NNS cord-326673-p8qbxi57 105 25 , , , cord-326673-p8qbxi57 105 26 as as IN cord-326673-p8qbxi57 105 27 there there EX cord-326673-p8qbxi57 105 28 was be VBD cord-326673-p8qbxi57 105 29 no no DT cord-326673-p8qbxi57 105 30 statistically statistically RB cord-326673-p8qbxi57 105 31 significant significant JJ cord-326673-p8qbxi57 105 32 difference difference NN cord-326673-p8qbxi57 105 33 between between IN cord-326673-p8qbxi57 105 34 antibody antibody NN cord-326673-p8qbxi57 105 35 levels level NNS cord-326673-p8qbxi57 105 36 in in IN cord-326673-p8qbxi57 105 37 the the DT cord-326673-p8qbxi57 105 38 vaccinated vaccinated JJ cord-326673-p8qbxi57 105 39 groups group NNS cord-326673-p8qbxi57 105 40 and and CC cord-326673-p8qbxi57 105 41 unvaccinated unvaccinated JJ cord-326673-p8qbxi57 105 42 control control NN cord-326673-p8qbxi57 105 43 groups group NNS cord-326673-p8qbxi57 105 44 . . . cord-326673-p8qbxi57 106 1 When when WRB cord-326673-p8qbxi57 106 2 calves calf NNS cord-326673-p8qbxi57 106 3 which which WDT cord-326673-p8qbxi57 106 4 had have VBD cord-326673-p8qbxi57 106 5 previously previously RB cord-326673-p8qbxi57 106 6 failed fail VBN cord-326673-p8qbxi57 106 7 to to TO cord-326673-p8qbxi57 106 8 respond respond VB cord-326673-p8qbxi57 106 9 to to IN cord-326673-p8qbxi57 106 10 vaccination vaccination NN cord-326673-p8qbxi57 106 11 because because IN cord-326673-p8qbxi57 106 12 of of IN cord-326673-p8qbxi57 106 13 MDA MDA NNP cord-326673-p8qbxi57 106 14 were be VBD cord-326673-p8qbxi57 106 15 revaccinated revaccinate VBN cord-326673-p8qbxi57 106 16 at at IN cord-326673-p8qbxi57 106 17 an an DT cord-326673-p8qbxi57 106 18 age age NN cord-326673-p8qbxi57 106 19 at at IN cord-326673-p8qbxi57 106 20 which which WDT cord-326673-p8qbxi57 106 21 MDA MDA NNP cord-326673-p8qbxi57 106 22 no no RB cord-326673-p8qbxi57 106 23 longer long RBR cord-326673-p8qbxi57 106 24 interfered interfere VBD cord-326673-p8qbxi57 106 25 with with IN cord-326673-p8qbxi57 106 26 the the DT cord-326673-p8qbxi57 106 27 response response NN cord-326673-p8qbxi57 106 28 ( ( -LRB- cord-326673-p8qbxi57 106 29 i.e. i.e. FW cord-326673-p8qbxi57 106 30 at at IN cord-326673-p8qbxi57 106 31 5 5 CD cord-326673-p8qbxi57 106 32 or or CC cord-326673-p8qbxi57 106 33 6 6 CD cord-326673-p8qbxi57 106 34 months month NNS cord-326673-p8qbxi57 106 35 of of IN cord-326673-p8qbxi57 106 36 age age NN cord-326673-p8qbxi57 106 37 ) ) -RRB- cord-326673-p8qbxi57 106 38 , , , cord-326673-p8qbxi57 106 39 there there EX cord-326673-p8qbxi57 106 40 was be VBD cord-326673-p8qbxi57 106 41 no no DT cord-326673-p8qbxi57 106 42 evidence evidence NN cord-326673-p8qbxi57 106 43 that that IN cord-326673-p8qbxi57 106 44 these these DT cord-326673-p8qbxi57 106 45 calves calf NNS cord-326673-p8qbxi57 106 46 had have VBD cord-326673-p8qbxi57 106 47 been be VBN cord-326673-p8qbxi57 106 48 primed prime VBN cord-326673-p8qbxi57 106 49 by by IN cord-326673-p8qbxi57 106 50 the the DT cord-326673-p8qbxi57 106 51 first first JJ cord-326673-p8qbxi57 106 52 vaccination vaccination NN cord-326673-p8qbxi57 106 53 . . . cord-326673-p8qbxi57 107 1 They -PRON- PRP cord-326673-p8qbxi57 107 2 showed show VBD cord-326673-p8qbxi57 107 3 a a DT cord-326673-p8qbxi57 107 4 similar similar JJ cord-326673-p8qbxi57 107 5 response response NN cord-326673-p8qbxi57 107 6 to to IN cord-326673-p8qbxi57 107 7 vaccination vaccination NN cord-326673-p8qbxi57 107 8 as as IN cord-326673-p8qbxi57 107 9 totally totally RB cord-326673-p8qbxi57 107 10 naive naive JJ cord-326673-p8qbxi57 107 11 calves calf NNS cord-326673-p8qbxi57 107 12 . . . cord-326673-p8qbxi57 108 1 This this DT cord-326673-p8qbxi57 108 2 is be VBZ cord-326673-p8qbxi57 108 3 contrary contrary JJ cord-326673-p8qbxi57 108 4 to to IN cord-326673-p8qbxi57 108 5 the the DT cord-326673-p8qbxi57 108 6 results result NNS cord-326673-p8qbxi57 108 7 of of IN cord-326673-p8qbxi57 108 8 Nicholls Nicholls NNP cord-326673-p8qbxi57 108 9 et et NNP cord-326673-p8qbxi57 108 10 al al NNP cord-326673-p8qbxi57 108 11 . . . cord-326673-p8qbxi57 109 1 ( ( -LRB- cord-326673-p8qbxi57 109 2 1984 1984 CD cord-326673-p8qbxi57 109 3 ) ) -RRB- cord-326673-p8qbxi57 109 4 , , , cord-326673-p8qbxi57 109 5 although although IN cord-326673-p8qbxi57 109 6 it -PRON- PRP cord-326673-p8qbxi57 109 7 is be VBZ cord-326673-p8qbxi57 109 8 acknowledged acknowledge VBN cord-326673-p8qbxi57 109 9 that that IN cord-326673-p8qbxi57 109 10 comparisons comparison NNS cord-326673-p8qbxi57 109 11 between between IN cord-326673-p8qbxi57 109 12 free free JJ cord-326673-p8qbxi57 109 13 ranging range VBG cord-326673-p8qbxi57 109 14 South south JJ cord-326673-p8qbxi57 109 15 American american JJ cord-326673-p8qbxi57 109 16 cattle cattle NNS cord-326673-p8qbxi57 109 17 and and CC cord-326673-p8qbxi57 109 18 zero zero CD cord-326673-p8qbxi57 109 19 - - HYPH cord-326673-p8qbxi57 109 20 grazed graze VBN cord-326673-p8qbxi57 109 21 intensively intensively RB cord-326673-p8qbxi57 109 22 - - HYPH cord-326673-p8qbxi57 109 23 reared rear VBN cord-326673-p8qbxi57 109 24 dairy dairy NN cord-326673-p8qbxi57 109 25 animals animal NNS cord-326673-p8qbxi57 109 26 in in IN cord-326673-p8qbxi57 109 27 the the DT cord-326673-p8qbxi57 109 28 Middle Middle NNP cord-326673-p8qbxi57 109 29 East East NNP cord-326673-p8qbxi57 109 30 may may MD cord-326673-p8qbxi57 109 31 not not RB cord-326673-p8qbxi57 109 32 apply apply VB cord-326673-p8qbxi57 109 33 . . . cord-326673-p8qbxi57 110 1 Calves calf NNS cord-326673-p8qbxi57 110 2 with with IN cord-326673-p8qbxi57 110 3 waning wane VBG cord-326673-p8qbxi57 110 4 MDA MDA NNP cord-326673-p8qbxi57 110 5 could could MD cord-326673-p8qbxi57 110 6 become become VB cord-326673-p8qbxi57 110 7 clinically clinically RB cord-326673-p8qbxi57 110 8 infected infect VBN cord-326673-p8qbxi57 110 9 with with IN cord-326673-p8qbxi57 110 10 FMD FMD NNP cord-326673-p8qbxi57 110 11 virus virus NN cord-326673-p8qbxi57 110 12 prior prior RB cord-326673-p8qbxi57 110 13 to to IN cord-326673-p8qbxi57 110 14 being be VBG cord-326673-p8qbxi57 110 15 able able JJ cord-326673-p8qbxi57 110 16 to to TO cord-326673-p8qbxi57 110 17 respond respond VB cord-326673-p8qbxi57 110 18 to to IN cord-326673-p8qbxi57 110 19 FMD FMD NNP cord-326673-p8qbxi57 110 20 vaccination vaccination NN cord-326673-p8qbxi57 110 21 . . . cord-326673-p8qbxi57 111 1 Calves calf NNS cord-326673-p8qbxi57 111 2 with with IN cord-326673-p8qbxi57 111 3 antibody antibody NN cord-326673-p8qbxi57 111 4 titres titre NNS cord-326673-p8qbxi57 111 5 below below IN cord-326673-p8qbxi57 111 6 1:100 1:100 CD cord-326673-p8qbxi57 111 7 , , , cord-326673-p8qbxi57 111 8 measured measure VBN cord-326673-p8qbxi57 111 9 using use VBG cord-326673-p8qbxi57 111 10 the the DT cord-326673-p8qbxi57 111 11 liquid liquid JJ cord-326673-p8qbxi57 111 12 phase phase NN cord-326673-p8qbxi57 111 13 enzyme enzyme NN cord-326673-p8qbxi57 111 14 - - HYPH cord-326673-p8qbxi57 111 15 linked link VBN cord-326673-p8qbxi57 111 16 imnmnosorbent imnmnosorbent NN cord-326673-p8qbxi57 111 17 assay assay NN cord-326673-p8qbxi57 111 18 ( ( -LRB- cord-326673-p8qbxi57 111 19 Hamblin Hamblin NNP cord-326673-p8qbxi57 111 20 et et NNP cord-326673-p8qbxi57 111 21 al al NNP cord-326673-p8qbxi57 111 22 . . NNP cord-326673-p8qbxi57 111 23 , , , cord-326673-p8qbxi57 111 24 1987 1987 CD cord-326673-p8qbxi57 111 25 ) ) -RRB- cord-326673-p8qbxi57 111 26 , , , cord-326673-p8qbxi57 111 27 became become VBD cord-326673-p8qbxi57 111 28 susceptible susceptible JJ cord-326673-p8qbxi57 111 29 to to IN cord-326673-p8qbxi57 111 30 infection infection NN cord-326673-p8qbxi57 111 31 , , , cord-326673-p8qbxi57 111 32 depending depend VBG cord-326673-p8qbxi57 111 33 on on IN cord-326673-p8qbxi57 111 34 the the DT cord-326673-p8qbxi57 111 35 level level NN cord-326673-p8qbxi57 111 36 of of IN cord-326673-p8qbxi57 111 37 FMD FMD NNP cord-326673-p8qbxi57 111 38 virus virus NN cord-326673-p8qbxi57 111 39 challenge challenge NN cord-326673-p8qbxi57 111 40 . . . cord-326673-p8qbxi57 112 1 However however RB cord-326673-p8qbxi57 112 2 , , , cord-326673-p8qbxi57 112 3 calves calf NNS cord-326673-p8qbxi57 112 4 with with IN cord-326673-p8qbxi57 112 5 titres titre NNS cord-326673-p8qbxi57 112 6 greater great JJR cord-326673-p8qbxi57 112 7 than than IN cord-326673-p8qbxi57 112 8 1:45 1:45 CD cord-326673-p8qbxi57 112 9 failed fail VBD cord-326673-p8qbxi57 112 10 to to TO cord-326673-p8qbxi57 112 11 respond respond VB cord-326673-p8qbxi57 112 12 to to IN cord-326673-p8qbxi57 112 13 vaccination vaccination NN cord-326673-p8qbxi57 112 14 . . . cord-326673-p8qbxi57 113 1 This this DT cord-326673-p8qbxi57 113 2 situation situation NN cord-326673-p8qbxi57 113 3 accounted account VBD cord-326673-p8qbxi57 113 4 for for IN cord-326673-p8qbxi57 113 5 the the DT cord-326673-p8qbxi57 113 6 persistence persistence NN cord-326673-p8qbxi57 113 7 of of IN cord-326673-p8qbxi57 113 8 FMD FMD NNP cord-326673-p8qbxi57 113 9 on on IN cord-326673-p8qbxi57 113 10 one one CD cord-326673-p8qbxi57 113 11 large large JJ cord-326673-p8qbxi57 113 12 farm farm NN cord-326673-p8qbxi57 113 13 , , , cord-326673-p8qbxi57 113 14 where where WRB cord-326673-p8qbxi57 113 15 the the DT cord-326673-p8qbxi57 113 16 5-month 5-month JJ cord-326673-p8qbxi57 113 17 - - HYPH cord-326673-p8qbxi57 113 18 old old JJ cord-326673-p8qbxi57 113 19 age age NN cord-326673-p8qbxi57 113 20 group group NN cord-326673-p8qbxi57 113 21 would would MD cord-326673-p8qbxi57 113 22 become become VB cord-326673-p8qbxi57 113 23 infected infected JJ cord-326673-p8qbxi57 113 24 , , , cord-326673-p8qbxi57 113 25 maintain maintain VB cord-326673-p8qbxi57 113 26 infection infection NN cord-326673-p8qbxi57 113 27 in in IN cord-326673-p8qbxi57 113 28 the the DT cord-326673-p8qbxi57 113 29 group group NN cord-326673-p8qbxi57 113 30 for for IN cord-326673-p8qbxi57 113 31 approximately approximately RB cord-326673-p8qbxi57 113 32 1 1 CD cord-326673-p8qbxi57 113 33 month month NN cord-326673-p8qbxi57 113 34 and and CC cord-326673-p8qbxi57 113 35 then then RB cord-326673-p8qbxi57 113 36 pass pass VB cord-326673-p8qbxi57 113 37 infection infection NN cord-326673-p8qbxi57 113 38 to to IN cord-326673-p8qbxi57 113 39 the the DT cord-326673-p8qbxi57 113 40 next next JJ cord-326673-p8qbxi57 113 41 , , , cord-326673-p8qbxi57 113 42 1 1 CD cord-326673-p8qbxi57 113 43 month month NN cord-326673-p8qbxi57 113 44 younger young JJR cord-326673-p8qbxi57 113 45 group group NN cord-326673-p8qbxi57 113 46 with with IN cord-326673-p8qbxi57 113 47 which which WDT cord-326673-p8qbxi57 113 48 it -PRON- PRP cord-326673-p8qbxi57 113 49 was be VBD cord-326673-p8qbxi57 113 50 in in IN cord-326673-p8qbxi57 113 51 contact contact NN cord-326673-p8qbxi57 113 52 and and CC cord-326673-p8qbxi57 113 53 which which WDT cord-326673-p8qbxi57 113 54 was be VBD cord-326673-p8qbxi57 113 55 just just RB cord-326673-p8qbxi57 113 56 developing develop VBG cord-326673-p8qbxi57 113 57 susceptibility susceptibility NN cord-326673-p8qbxi57 113 58 to to IN cord-326673-p8qbxi57 113 59 infection infection NN cord-326673-p8qbxi57 113 60 , , , cord-326673-p8qbxi57 113 61 in in IN cord-326673-p8qbxi57 113 62 spite spite NN cord-326673-p8qbxi57 113 63 of of IN cord-326673-p8qbxi57 113 64 this this DT cord-326673-p8qbxi57 113 65 younger young JJR cord-326673-p8qbxi57 113 66 group group NN cord-326673-p8qbxi57 113 67 receiving receive VBG cord-326673-p8qbxi57 113 68 vaccination vaccination NN cord-326673-p8qbxi57 113 69 . . . cord-326673-p8qbxi57 114 1 At at IN cord-326673-p8qbxi57 114 2 all all DT cord-326673-p8qbxi57 114 3 times time NNS cord-326673-p8qbxi57 114 4 during during IN cord-326673-p8qbxi57 114 5 the the DT cord-326673-p8qbxi57 114 6 study study NN cord-326673-p8qbxi57 114 7 the the DT cord-326673-p8qbxi57 114 8 strain strain NN cord-326673-p8qbxi57 114 9 of of IN cord-326673-p8qbxi57 114 10 FMD FMD NNP cord-326673-p8qbxi57 114 11 virus virus NN cord-326673-p8qbxi57 114 12 causing cause VBG cord-326673-p8qbxi57 114 13 the the DT cord-326673-p8qbxi57 114 14 outbreaks outbreak NNS cord-326673-p8qbxi57 114 15 was be VBD cord-326673-p8qbxi57 114 16 monitored monitor VBN cord-326673-p8qbxi57 114 17 for for IN cord-326673-p8qbxi57 114 18 changes change NNS cord-326673-p8qbxi57 114 19 in in IN cord-326673-p8qbxi57 114 20 antigenic antigenic JJ cord-326673-p8qbxi57 114 21 characteristics characteristic NNS cord-326673-p8qbxi57 114 22 which which WDT cord-326673-p8qbxi57 114 23 could could MD cord-326673-p8qbxi57 114 24 modify modify VB cord-326673-p8qbxi57 114 25 the the DT cord-326673-p8qbxi57 114 26 interpretation interpretation NN cord-326673-p8qbxi57 114 27 of of IN cord-326673-p8qbxi57 114 28 the the DT cord-326673-p8qbxi57 114 29 results result NNS cord-326673-p8qbxi57 114 30 . . . cord-326673-p8qbxi57 115 1 Surprisingly surprisingly RB cord-326673-p8qbxi57 115 2 , , , cord-326673-p8qbxi57 115 3 the the DT cord-326673-p8qbxi57 115 4 virus virus NN cord-326673-p8qbxi57 115 5 remained remain VBD cord-326673-p8qbxi57 115 6 antigenically antigenically RB cord-326673-p8qbxi57 115 7 stable stable JJ cord-326673-p8qbxi57 115 8 over over IN cord-326673-p8qbxi57 115 9 the the DT cord-326673-p8qbxi57 115 10 4-year 4-year JJ cord-326673-p8qbxi57 115 11 period period NN cord-326673-p8qbxi57 115 12 of of IN cord-326673-p8qbxi57 115 13 the the DT cord-326673-p8qbxi57 115 14 study study NN cord-326673-p8qbxi57 115 15 , , , cord-326673-p8qbxi57 115 16 even even RB cord-326673-p8qbxi57 115 17 though though IN cord-326673-p8qbxi57 115 18 the the DT cord-326673-p8qbxi57 115 19 pressure pressure NN cord-326673-p8qbxi57 115 20 to to TO cord-326673-p8qbxi57 115 21 mutate mutate VB cord-326673-p8qbxi57 115 22 in in IN cord-326673-p8qbxi57 115 23 order order NN cord-326673-p8qbxi57 115 24 to to TO cord-326673-p8qbxi57 115 25 evade evade VB cord-326673-p8qbxi57 115 26 vaccinal vaccinal JJ cord-326673-p8qbxi57 115 27 immunity immunity NN cord-326673-p8qbxi57 115 28 was be VBD cord-326673-p8qbxi57 115 29 very very RB cord-326673-p8qbxi57 115 30 great great JJ cord-326673-p8qbxi57 115 31 . . . cord-326673-p8qbxi57 116 1 The the DT cord-326673-p8qbxi57 116 2 conclusion conclusion NN cord-326673-p8qbxi57 116 3 of of IN cord-326673-p8qbxi57 116 4 the the DT cord-326673-p8qbxi57 116 5 study study NN cord-326673-p8qbxi57 116 6 was be VBD cord-326673-p8qbxi57 116 7 that that IN cord-326673-p8qbxi57 116 8 together together RB cord-326673-p8qbxi57 116 9 with with IN cord-326673-p8qbxi57 116 10 a a DT cord-326673-p8qbxi57 116 11 number number NN cord-326673-p8qbxi57 116 12 of of IN cord-326673-p8qbxi57 116 13 management management NN cord-326673-p8qbxi57 116 14 recommendations recommendation NNS cord-326673-p8qbxi57 116 15 , , , cord-326673-p8qbxi57 116 16 the the DT cord-326673-p8qbxi57 116 17 most most RBS cord-326673-p8qbxi57 116 18 effective effective JJ cord-326673-p8qbxi57 116 19 vaccination vaccination NN cord-326673-p8qbxi57 116 20 programme programme NN cord-326673-p8qbxi57 116 21 for for IN cord-326673-p8qbxi57 116 22 calves calf NNS cord-326673-p8qbxi57 116 23 of of IN cord-326673-p8qbxi57 116 24 well well RB cord-326673-p8qbxi57 116 25 vaccinated vaccinate VBN cord-326673-p8qbxi57 116 26 dams dam NNS cord-326673-p8qbxi57 116 27 , , , cord-326673-p8qbxi57 116 28 was be VBD cord-326673-p8qbxi57 116 29 vaccination vaccination NN cord-326673-p8qbxi57 116 30 of of IN cord-326673-p8qbxi57 116 31 all all DT cord-326673-p8qbxi57 116 32 calves calf NNS cord-326673-p8qbxi57 116 33 at at IN cord-326673-p8qbxi57 116 34 4 4 CD cord-326673-p8qbxi57 116 35 , , , cord-326673-p8qbxi57 116 36 5 5 CD cord-326673-p8qbxi57 116 37 and and CC cord-326673-p8qbxi57 116 38 6 6 CD cord-326673-p8qbxi57 116 39 months month NNS cord-326673-p8qbxi57 116 40 of of IN cord-326673-p8qbxi57 116 41 age age NN cord-326673-p8qbxi57 116 42 , , , cord-326673-p8qbxi57 116 43 to to TO cord-326673-p8qbxi57 116 44 ensure ensure VB cord-326673-p8qbxi57 116 45 that that IN cord-326673-p8qbxi57 116 46 all all DT cord-326673-p8qbxi57 116 47 calves calf NNS cord-326673-p8qbxi57 116 48 had have VBD cord-326673-p8qbxi57 116 49 good good JJ cord-326673-p8qbxi57 116 50 levels level NNS cord-326673-p8qbxi57 116 51 of of IN cord-326673-p8qbxi57 116 52 protection protection NN cord-326673-p8qbxi57 116 53 . . . cord-326673-p8qbxi57 117 1 Vaccination vaccination NN cord-326673-p8qbxi57 117 2 of of IN cord-326673-p8qbxi57 117 3 pigs pig NNS cord-326673-p8qbxi57 117 4 against against IN cord-326673-p8qbxi57 117 5 FMD FMD NNP cord-326673-p8qbxi57 117 6 is be VBZ cord-326673-p8qbxi57 117 7 less less RBR cord-326673-p8qbxi57 117 8 widely widely RB cord-326673-p8qbxi57 117 9 practised practise VBN cord-326673-p8qbxi57 117 10 due due IN cord-326673-p8qbxi57 117 11 to to IN cord-326673-p8qbxi57 117 12 the the DT cord-326673-p8qbxi57 117 13 rapid rapid JJ cord-326673-p8qbxi57 117 14 turnover turnover NN cord-326673-p8qbxi57 117 15 in in IN cord-326673-p8qbxi57 117 16 the the DT cord-326673-p8qbxi57 117 17 pig pig NN cord-326673-p8qbxi57 117 18 population population NN cord-326673-p8qbxi57 117 19 . . . cord-326673-p8qbxi57 118 1 In in IN cord-326673-p8qbxi57 118 2 addition addition NN cord-326673-p8qbxi57 118 3 , , , cord-326673-p8qbxi57 118 4 the the DT cord-326673-p8qbxi57 118 5 immaturity immaturity NN cord-326673-p8qbxi57 118 6 of of IN cord-326673-p8qbxi57 118 7 the the DT cord-326673-p8qbxi57 118 8 immune immune JJ cord-326673-p8qbxi57 118 9 response response NN cord-326673-p8qbxi57 118 10 of of IN cord-326673-p8qbxi57 118 11 the the DT cord-326673-p8qbxi57 118 12 young young JJ cord-326673-p8qbxi57 118 13 pig pig NN cord-326673-p8qbxi57 118 14 makes make VBZ cord-326673-p8qbxi57 118 15 vaccination vaccination NN cord-326673-p8qbxi57 118 16 of of IN cord-326673-p8qbxi57 118 17 the the DT cord-326673-p8qbxi57 118 18 sow sow NN cord-326673-p8qbxi57 118 19 during during IN cord-326673-p8qbxi57 118 20 pregnancy pregnancy NN cord-326673-p8qbxi57 118 21 a a DT cord-326673-p8qbxi57 118 22 more more RBR cord-326673-p8qbxi57 118 23 effective effective JJ cord-326673-p8qbxi57 118 24 method method NN cord-326673-p8qbxi57 118 25 by by IN cord-326673-p8qbxi57 118 26 which which WDT cord-326673-p8qbxi57 118 27 to to TO cord-326673-p8qbxi57 118 28 protect protect VB cord-326673-p8qbxi57 118 29 the the DT cord-326673-p8qbxi57 118 30 litter litter NN cord-326673-p8qbxi57 118 31 . . . cord-326673-p8qbxi57 119 1 Some some DT cord-326673-p8qbxi57 119 2 response response NN cord-326673-p8qbxi57 119 3 to to IN cord-326673-p8qbxi57 119 4 vaccination vaccination NN cord-326673-p8qbxi57 119 5 in in IN cord-326673-p8qbxi57 119 6 8-week 8-week JJ cord-326673-p8qbxi57 119 7 - - JJ cord-326673-p8qbxi57 119 8 old old JJ cord-326673-p8qbxi57 119 9 pigs pig NNS cord-326673-p8qbxi57 119 10 in in IN cord-326673-p8qbxi57 119 11 the the DT cord-326673-p8qbxi57 119 12 presence presence NN cord-326673-p8qbxi57 119 13 of of IN cord-326673-p8qbxi57 119 14 MDA MDA NNP cord-326673-p8qbxi57 119 15 was be VBD cord-326673-p8qbxi57 119 16 shown show VBN cord-326673-p8qbxi57 119 17 by by IN cord-326673-p8qbxi57 119 18 Francis Francis NNP cord-326673-p8qbxi57 119 19 and and CC cord-326673-p8qbxi57 119 20 Black Black NNP cord-326673-p8qbxi57 119 21 ( ( -LRB- cord-326673-p8qbxi57 119 22 1986 1986 CD cord-326673-p8qbxi57 119 23 ) ) -RRB- cord-326673-p8qbxi57 119 24 . . . cord-326673-p8qbxi57 120 1 However however RB cord-326673-p8qbxi57 120 2 , , , cord-326673-p8qbxi57 120 3 it -PRON- PRP cord-326673-p8qbxi57 120 4 was be VBD cord-326673-p8qbxi57 120 5 the the DT cord-326673-p8qbxi57 120 6 recommendation recommendation NN cord-326673-p8qbxi57 120 7 of of IN cord-326673-p8qbxi57 120 8 Francis Francis NNP cord-326673-p8qbxi57 120 9 that that DT cord-326673-p8qbxi57 120 10 vaccination vaccination NN cord-326673-p8qbxi57 120 11 of of IN cord-326673-p8qbxi57 120 12 pigs pig NNS cord-326673-p8qbxi57 120 13 from from IN cord-326673-p8qbxi57 120 14 immune immune JJ cord-326673-p8qbxi57 120 15 sows sow NNS cord-326673-p8qbxi57 120 16 be be VB cord-326673-p8qbxi57 120 17 delayed delay VBN cord-326673-p8qbxi57 120 18 until until IN cord-326673-p8qbxi57 120 19 10 10 CD cord-326673-p8qbxi57 120 20 - - SYM cord-326673-p8qbxi57 120 21 12 12 CD cord-326673-p8qbxi57 120 22 weeks week NNS cord-326673-p8qbxi57 120 23 of of IN cord-326673-p8qbxi57 120 24 age age NN cord-326673-p8qbxi57 120 25 , , , cord-326673-p8qbxi57 120 26 although although IN cord-326673-p8qbxi57 120 27 additional additional JJ cord-326673-p8qbxi57 120 28 vaccination vaccination NN cord-326673-p8qbxi57 120 29 at at IN cord-326673-p8qbxi57 120 30 2 2 CD cord-326673-p8qbxi57 120 31 - - SYM cord-326673-p8qbxi57 120 32 4 4 CD cord-326673-p8qbxi57 120 33 weeks week NNS cord-326673-p8qbxi57 120 34 of of IN cord-326673-p8qbxi57 120 35 age age NN cord-326673-p8qbxi57 120 36 could could MD cord-326673-p8qbxi57 120 37 be be VB cord-326673-p8qbxi57 120 38 justified justify VBN cord-326673-p8qbxi57 120 39 in in IN cord-326673-p8qbxi57 120 40 order order NN cord-326673-p8qbxi57 120 41 to to TO cord-326673-p8qbxi57 120 42 protect protect VB cord-326673-p8qbxi57 120 43 those those DT cord-326673-p8qbxi57 120 44 piglets piglet NNS cord-326673-p8qbxi57 120 45 which which WDT cord-326673-p8qbxi57 120 46 had have VBD cord-326673-p8qbxi57 120 47 received receive VBN cord-326673-p8qbxi57 120 48 insufficient insufficient JJ cord-326673-p8qbxi57 120 49 MDA MDA NNP cord-326673-p8qbxi57 120 50 ( ( -LRB- cord-326673-p8qbxi57 120 51 Francis Francis NNP cord-326673-p8qbxi57 120 52 , , , cord-326673-p8qbxi57 120 53 1986 1986 CD cord-326673-p8qbxi57 120 54 ) ) -RRB- cord-326673-p8qbxi57 120 55 . . . cord-326673-p8qbxi57 121 1 Francis Francis NNP cord-326673-p8qbxi57 121 2 and and CC cord-326673-p8qbxi57 121 3 Black Black NNP cord-326673-p8qbxi57 121 4 ( ( -LRB- cord-326673-p8qbxi57 121 5 1984 1984 CD cord-326673-p8qbxi57 121 6 ) ) -RRB- cord-326673-p8qbxi57 121 7 found find VBD cord-326673-p8qbxi57 121 8 no no DT cord-326673-p8qbxi57 121 9 evidence evidence NN cord-326673-p8qbxi57 121 10 in in IN cord-326673-p8qbxi57 121 11 the the DT cord-326673-p8qbxi57 121 12 pig pig NN cord-326673-p8qbxi57 121 13 that that WDT cord-326673-p8qbxi57 121 14 vaccination vaccination NN cord-326673-p8qbxi57 121 15 in in IN cord-326673-p8qbxi57 121 16 the the DT cord-326673-p8qbxi57 121 17 presence presence NN cord-326673-p8qbxi57 121 18 of of IN cord-326673-p8qbxi57 121 19 MDA MDA NNP cord-326673-p8qbxi57 121 20 depressed depress VBD cord-326673-p8qbxi57 121 21 the the DT cord-326673-p8qbxi57 121 22 specific specific JJ cord-326673-p8qbxi57 121 23 antibody antibody NN cord-326673-p8qbxi57 121 24 to to IN cord-326673-p8qbxi57 121 25 FMD FMD NNP cord-326673-p8qbxi57 121 26 virus virus NN cord-326673-p8qbxi57 121 27 . . . cord-326673-p8qbxi57 122 1 The the DT cord-326673-p8qbxi57 122 2 vaccines vaccine NNS cord-326673-p8qbxi57 122 3 used use VBN cord-326673-p8qbxi57 122 4 in in IN cord-326673-p8qbxi57 122 5 cattle cattle NNS cord-326673-p8qbxi57 122 6 outside outside RB cord-326673-p8qbxi57 122 7 of of IN cord-326673-p8qbxi57 122 8 South South NNP cord-326673-p8qbxi57 122 9 America America NNP cord-326673-p8qbxi57 122 10 against against IN cord-326673-p8qbxi57 122 11 FMD FMD NNP cord-326673-p8qbxi57 122 12 use use VBP cord-326673-p8qbxi57 122 13 a a DT cord-326673-p8qbxi57 122 14 saponin saponin NN cord-326673-p8qbxi57 122 15 and and CC cord-326673-p8qbxi57 122 16 aluminium aluminium NN cord-326673-p8qbxi57 122 17 hydroxide hydroxide NN cord-326673-p8qbxi57 122 18 adjuvant adjuvant NN cord-326673-p8qbxi57 122 19 . . . cord-326673-p8qbxi57 123 1 These these DT cord-326673-p8qbxi57 123 2 vaccines vaccine NNS cord-326673-p8qbxi57 123 3 are be VBP cord-326673-p8qbxi57 123 4 less less RBR cord-326673-p8qbxi57 123 5 effective effective JJ cord-326673-p8qbxi57 123 6 in in IN cord-326673-p8qbxi57 123 7 pigs pig NNS cord-326673-p8qbxi57 123 8 , , , cord-326673-p8qbxi57 123 9 and and CC cord-326673-p8qbxi57 123 10 an an DT cord-326673-p8qbxi57 123 11 oil oil NN cord-326673-p8qbxi57 123 12 adjuvant adjuvant NN cord-326673-p8qbxi57 123 13 is be VBZ cord-326673-p8qbxi57 123 14 used use VBN cord-326673-p8qbxi57 123 15 in in IN cord-326673-p8qbxi57 123 16 pig pig NN cord-326673-p8qbxi57 123 17 FMD FMD NNP cord-326673-p8qbxi57 123 18 vaccines vaccine NNS cord-326673-p8qbxi57 123 19 . . . cord-326673-p8qbxi57 124 1 However however RB cord-326673-p8qbxi57 124 2 , , , cord-326673-p8qbxi57 124 3 in in IN cord-326673-p8qbxi57 124 4 South South NNP cord-326673-p8qbxi57 124 5 America America NNP cord-326673-p8qbxi57 124 6 , , , cord-326673-p8qbxi57 124 7 oil oil NN cord-326673-p8qbxi57 124 8 adjuranted adjurante VBD cord-326673-p8qbxi57 124 9 FMD FMD NNP cord-326673-p8qbxi57 124 10 vaccines vaccine NNS cord-326673-p8qbxi57 124 11 are be VBP cord-326673-p8qbxi57 124 12 used use VBN cord-326673-p8qbxi57 124 13 in in IN cord-326673-p8qbxi57 124 14 cattle cattle NNS cord-326673-p8qbxi57 124 15 , , , cord-326673-p8qbxi57 124 16 and and CC cord-326673-p8qbxi57 124 17 it -PRON- PRP cord-326673-p8qbxi57 124 18 is be VBZ cord-326673-p8qbxi57 124 19 claimed claim VBN cord-326673-p8qbxi57 124 20 that that IN cord-326673-p8qbxi57 124 21 these these DT cord-326673-p8qbxi57 124 22 vaccines vaccine NNS cord-326673-p8qbxi57 124 23 overcome overcome VBP cord-326673-p8qbxi57 124 24 the the DT cord-326673-p8qbxi57 124 25 depressive depressive JJ cord-326673-p8qbxi57 124 26 effects effect NNS cord-326673-p8qbxi57 124 27 of of IN cord-326673-p8qbxi57 124 28 MDA MDA NNP cord-326673-p8qbxi57 124 29 ( ( -LRB- cord-326673-p8qbxi57 124 30 Sadir Sadir NNP cord-326673-p8qbxi57 124 31 et et NNP cord-326673-p8qbxi57 124 32 al al NNP cord-326673-p8qbxi57 124 33 . . NNP cord-326673-p8qbxi57 124 34 , , , cord-326673-p8qbxi57 124 35 1988 1988 CD cord-326673-p8qbxi57 124 36 ) ) -RRB- cord-326673-p8qbxi57 124 37 . . . cord-326673-p8qbxi57 125 1 Experimental experimental JJ cord-326673-p8qbxi57 125 2 results result NNS cord-326673-p8qbxi57 125 3 showed show VBD cord-326673-p8qbxi57 125 4 that that IN cord-326673-p8qbxi57 125 5 calves calf NNS cord-326673-p8qbxi57 125 6 over over IN cord-326673-p8qbxi57 125 7 30 30 CD cord-326673-p8qbxi57 125 8 days day NNS cord-326673-p8qbxi57 125 9 of of IN cord-326673-p8qbxi57 125 10 age age NN cord-326673-p8qbxi57 125 11 , , , cord-326673-p8qbxi57 125 12 but but CC cord-326673-p8qbxi57 125 13 still still RB cord-326673-p8qbxi57 125 14 with with IN cord-326673-p8qbxi57 125 15 MDA MDA NNP cord-326673-p8qbxi57 125 16 , , , cord-326673-p8qbxi57 125 17 responded respond VBD cord-326673-p8qbxi57 125 18 as as RB cord-326673-p8qbxi57 125 19 well well RB cord-326673-p8qbxi57 125 20 as as IN cord-326673-p8qbxi57 125 21 adult adult NN cord-326673-p8qbxi57 125 22 cattle cattle NNS cord-326673-p8qbxi57 125 23 to to IN cord-326673-p8qbxi57 125 24 the the DT cord-326673-p8qbxi57 125 25 oil oil NN cord-326673-p8qbxi57 125 26 - - HYPH cord-326673-p8qbxi57 125 27 emulsified emulsify VBN cord-326673-p8qbxi57 125 28 FMD FMD NNP cord-326673-p8qbxi57 125 29 vaccine vaccine NN cord-326673-p8qbxi57 125 30 . . . cord-326673-p8qbxi57 126 1 However however RB cord-326673-p8qbxi57 126 2 , , , cord-326673-p8qbxi57 126 3 there there EX cord-326673-p8qbxi57 126 4 was be VBD cord-326673-p8qbxi57 126 5 a a DT cord-326673-p8qbxi57 126 6 30 30 CD cord-326673-p8qbxi57 126 7 - - SYM cord-326673-p8qbxi57 126 8 60 60 CD cord-326673-p8qbxi57 126 9 day day NN cord-326673-p8qbxi57 126 10 delayed delay VBN cord-326673-p8qbxi57 126 11 response response NN cord-326673-p8qbxi57 126 12 in in IN cord-326673-p8qbxi57 126 13 MDA MDA NNP cord-326673-p8qbxi57 126 14 free free JJ cord-326673-p8qbxi57 126 15 calves calf NNS cord-326673-p8qbxi57 126 16 under under IN cord-326673-p8qbxi57 126 17 7 7 CD cord-326673-p8qbxi57 126 18 days day NNS cord-326673-p8qbxi57 126 19 of of IN cord-326673-p8qbxi57 126 20 age age NN cord-326673-p8qbxi57 126 21 vaccinated vaccinate VBN cord-326673-p8qbxi57 126 22 with with IN cord-326673-p8qbxi57 126 23 this this DT cord-326673-p8qbxi57 126 24 vaccine vaccine NN cord-326673-p8qbxi57 126 25 , , , cord-326673-p8qbxi57 126 26 which which WDT cord-326673-p8qbxi57 126 27 was be VBD cord-326673-p8qbxi57 126 28 suggested suggest VBN cord-326673-p8qbxi57 126 29 to to TO cord-326673-p8qbxi57 126 30 be be VB cord-326673-p8qbxi57 126 31 due due JJ cord-326673-p8qbxi57 126 32 to to IN cord-326673-p8qbxi57 126 33 high high JJ cord-326673-p8qbxi57 126 34 levels level NNS cord-326673-p8qbxi57 126 35 of of IN cord-326673-p8qbxi57 126 36 cortical cortical JJ cord-326673-p8qbxi57 126 37 hormones hormone NNS cord-326673-p8qbxi57 126 38 ( ( -LRB- cord-326673-p8qbxi57 126 39 Sadir Sadir NNP cord-326673-p8qbxi57 126 40 et et NNP cord-326673-p8qbxi57 126 41 al al NNP cord-326673-p8qbxi57 126 42 . . NNP cord-326673-p8qbxi57 126 43 , , , cord-326673-p8qbxi57 126 44 1988 1988 CD cord-326673-p8qbxi57 126 45 ) ) -RRB- cord-326673-p8qbxi57 126 46 . . . cord-326673-p8qbxi57 127 1 In in IN cord-326673-p8qbxi57 127 2 summal summal JJ cord-326673-p8qbxi57 127 3 T T NNP cord-326673-p8qbxi57 127 4 , , , cord-326673-p8qbxi57 127 5 it -PRON- PRP cord-326673-p8qbxi57 127 6 has have VBZ cord-326673-p8qbxi57 127 7 been be VBN cord-326673-p8qbxi57 127 8 shown show VBN cord-326673-p8qbxi57 127 9 for for IN cord-326673-p8qbxi57 127 10 several several JJ cord-326673-p8qbxi57 127 11 of of IN cord-326673-p8qbxi57 127 12 the the DT cord-326673-p8qbxi57 127 13 domesticated domesticate VBN cord-326673-p8qbxi57 127 14 species specie NNS cord-326673-p8qbxi57 127 15 that that WDT cord-326673-p8qbxi57 127 16 MDA MDA NNP cord-326673-p8qbxi57 127 17 can can MD cord-326673-p8qbxi57 127 18 have have VB cord-326673-p8qbxi57 127 19 a a DT cord-326673-p8qbxi57 127 20 marked mark VBN cord-326673-p8qbxi57 127 21 antigen antigen NN cord-326673-p8qbxi57 127 22 - - HYPH cord-326673-p8qbxi57 127 23 specific specific JJ cord-326673-p8qbxi57 127 24 suppressive suppressive JJ cord-326673-p8qbxi57 127 25 effect effect NN cord-326673-p8qbxi57 127 26 upon upon IN cord-326673-p8qbxi57 127 27 active active JJ cord-326673-p8qbxi57 127 28 antibody antibody NN cord-326673-p8qbxi57 127 29 production production NN cord-326673-p8qbxi57 127 30 in in IN cord-326673-p8qbxi57 127 31 the the DT cord-326673-p8qbxi57 127 32 young young JJ cord-326673-p8qbxi57 127 33 , , , cord-326673-p8qbxi57 127 34 the the DT cord-326673-p8qbxi57 127 35 degree degree NN cord-326673-p8qbxi57 127 36 and and CC cord-326673-p8qbxi57 127 37 duration duration NN cord-326673-p8qbxi57 127 38 of of IN cord-326673-p8qbxi57 127 39 which which WDT cord-326673-p8qbxi57 127 40 is be VBZ cord-326673-p8qbxi57 127 41 directly directly RB cord-326673-p8qbxi57 127 42 related relate VBN cord-326673-p8qbxi57 127 43 to to IN cord-326673-p8qbxi57 127 44 MDA MDA NNP cord-326673-p8qbxi57 127 45 titres titre NNS cord-326673-p8qbxi57 127 46 shortly shortly RB cord-326673-p8qbxi57 127 47 after after IN cord-326673-p8qbxi57 127 48 birth birth NN cord-326673-p8qbxi57 127 49 . . . cord-326673-p8qbxi57 128 1 There there EX cord-326673-p8qbxi57 128 2 is be VBZ cord-326673-p8qbxi57 128 3 a a DT cord-326673-p8qbxi57 128 4 gradual gradual JJ cord-326673-p8qbxi57 128 5 recovery recovery NN cord-326673-p8qbxi57 128 6 of of IN cord-326673-p8qbxi57 128 7 immune immune JJ cord-326673-p8qbxi57 128 8 function function NN cord-326673-p8qbxi57 128 9 in in IN cord-326673-p8qbxi57 128 10 which which WDT cord-326673-p8qbxi57 128 11 the the DT cord-326673-p8qbxi57 128 12 individual individual NN cord-326673-p8qbxi57 128 13 can can MD cord-326673-p8qbxi57 128 14 become become VB cord-326673-p8qbxi57 128 15 partially partially RB cord-326673-p8qbxi57 128 16 responsive responsive JJ cord-326673-p8qbxi57 128 17 prior prior RB cord-326673-p8qbxi57 128 18 to to IN cord-326673-p8qbxi57 128 19 the the DT cord-326673-p8qbxi57 128 20 acquisition acquisition NN cord-326673-p8qbxi57 128 21 of of IN cord-326673-p8qbxi57 128 22 full full JJ cord-326673-p8qbxi57 128 23 immunoconlpetence immunoconlpetence NN cord-326673-p8qbxi57 128 24 . . . cord-326673-p8qbxi57 129 1 The the DT cord-326673-p8qbxi57 129 2 precise precise JJ cord-326673-p8qbxi57 129 3 point point NN cord-326673-p8qbxi57 129 4 or or CC cord-326673-p8qbxi57 129 5 points point NNS cord-326673-p8qbxi57 129 6 in in IN cord-326673-p8qbxi57 129 7 the the DT cord-326673-p8qbxi57 129 8 immune immune JJ cord-326673-p8qbxi57 129 9 system system NN cord-326673-p8qbxi57 129 10 of of IN cord-326673-p8qbxi57 129 11 the the DT cord-326673-p8qbxi57 129 12 offspring offspring NN cord-326673-p8qbxi57 129 13 at at IN cord-326673-p8qbxi57 129 14 which which WDT cord-326673-p8qbxi57 129 15 maternally maternally RB cord-326673-p8qbxi57 129 16 - - HYPH cord-326673-p8qbxi57 129 17 derived derive VBN cord-326673-p8qbxi57 129 18 factors factor NNS cord-326673-p8qbxi57 129 19 interfere interfere VBP cord-326673-p8qbxi57 129 20 is be VBZ cord-326673-p8qbxi57 129 21 not not RB cord-326673-p8qbxi57 129 22 defined define VBN cord-326673-p8qbxi57 129 23 . . . cord-326673-p8qbxi57 130 1 Some some DT cord-326673-p8qbxi57 130 2 authors author NNS cord-326673-p8qbxi57 130 3 have have VBP cord-326673-p8qbxi57 130 4 described describe VBN cord-326673-p8qbxi57 130 5 generalized generalized JJ cord-326673-p8qbxi57 130 6 cellular cellular JJ cord-326673-p8qbxi57 130 7 responsiveness responsiveness NN cord-326673-p8qbxi57 130 8 ( ( -LRB- cord-326673-p8qbxi57 130 9 Clover Clover NNP cord-326673-p8qbxi57 130 10 & & CC cord-326673-p8qbxi57 130 11 Zarkower Zarkower NNP cord-326673-p8qbxi57 130 12 , , , cord-326673-p8qbxi57 130 13 1980 1980 CD cord-326673-p8qbxi57 130 14 ) ) -RRB- cord-326673-p8qbxi57 130 15 , , , cord-326673-p8qbxi57 130 16 and and CC cord-326673-p8qbxi57 130 17 others other NNS cord-326673-p8qbxi57 130 18 describe describe VBP cord-326673-p8qbxi57 130 19 antigen antigen NN cord-326673-p8qbxi57 130 20 - - HYPH cord-326673-p8qbxi57 130 21 specific specific JJ cord-326673-p8qbxi57 130 22 reduction reduction NN cord-326673-p8qbxi57 130 23 in in IN cord-326673-p8qbxi57 130 24 both both CC cord-326673-p8qbxi57 130 25 primary primary JJ cord-326673-p8qbxi57 130 26 and and CC cord-326673-p8qbxi57 130 27 secondary secondary JJ cord-326673-p8qbxi57 130 28 antibody antibody NN cord-326673-p8qbxi57 130 29 responses response NNS cord-326673-p8qbxi57 130 30 ( ( -LRB- cord-326673-p8qbxi57 130 31 Husband Husband NNP cord-326673-p8qbxi57 130 32 & & CC cord-326673-p8qbxi57 130 33 Lascelles Lascelles NNP cord-326673-p8qbxi57 130 34 , , , cord-326673-p8qbxi57 130 35 1975 1975 CD cord-326673-p8qbxi57 130 36 ) ) -RRB- cord-326673-p8qbxi57 130 37 . . . cord-326673-p8qbxi57 131 1 However however RB cord-326673-p8qbxi57 131 2 , , , cord-326673-p8qbxi57 131 3 it -PRON- PRP cord-326673-p8qbxi57 131 4 appears appear VBZ cord-326673-p8qbxi57 131 5 that that IN cord-326673-p8qbxi57 131 6 individual individual JJ cord-326673-p8qbxi57 131 7 lymphocyte lymphocyte NN cord-326673-p8qbxi57 131 8 subsets subset NNS cord-326673-p8qbxi57 131 9 may may MD cord-326673-p8qbxi57 131 10 be be VB cord-326673-p8qbxi57 131 11 more more RBR cord-326673-p8qbxi57 131 12 or or CC cord-326673-p8qbxi57 131 13 less less RBR cord-326673-p8qbxi57 131 14 susceptible susceptible JJ cord-326673-p8qbxi57 131 15 to to IN cord-326673-p8qbxi57 131 16 the the DT cord-326673-p8qbxi57 131 17 effects effect NNS cord-326673-p8qbxi57 131 18 of of IN cord-326673-p8qbxi57 131 19 MDA MDA NNP cord-326673-p8qbxi57 131 20 . . . cord-326673-p8qbxi57 132 1 Wittman Wittman NNP cord-326673-p8qbxi57 132 2 and and CC cord-326673-p8qbxi57 132 3 Ohlinger Ohlinger NNP cord-326673-p8qbxi57 132 4 ( ( -LRB- cord-326673-p8qbxi57 132 5 1987 1987 CD cord-326673-p8qbxi57 132 6 ) ) -RRB- cord-326673-p8qbxi57 132 7 found find VBD cord-326673-p8qbxi57 132 8 that that IN cord-326673-p8qbxi57 132 9 MDA MDA NNP cord-326673-p8qbxi57 132 10 titres titre NNS cord-326673-p8qbxi57 132 11 which which WDT cord-326673-p8qbxi57 132 12 interfered interfere VBD cord-326673-p8qbxi57 132 13 with with IN cord-326673-p8qbxi57 132 14 the the DT cord-326673-p8qbxi57 132 15 cytolytic cytolytic JJ cord-326673-p8qbxi57 132 16 T T NNP cord-326673-p8qbxi57 132 17 lymphocyte lymphocyte NN cord-326673-p8qbxi57 132 18 response response NN cord-326673-p8qbxi57 132 19 to to IN cord-326673-p8qbxi57 132 20 Aujeszky Aujeszky NNP cord-326673-p8qbxi57 132 21 's 's POS cord-326673-p8qbxi57 132 22 disease disease NN cord-326673-p8qbxi57 132 23 vaccination vaccination NN cord-326673-p8qbxi57 132 24 in in IN cord-326673-p8qbxi57 132 25 piglets piglet NNS cord-326673-p8qbxi57 132 26 did do VBD cord-326673-p8qbxi57 132 27 not not RB cord-326673-p8qbxi57 132 28 prevent prevent VB cord-326673-p8qbxi57 132 29 the the DT cord-326673-p8qbxi57 132 30 sensitization sensitization NN cord-326673-p8qbxi57 132 31 of of IN cord-326673-p8qbxi57 132 32 lymphocytes lymphocyte NNS cord-326673-p8qbxi57 132 33 for for IN cord-326673-p8qbxi57 132 34 antibody antibody NN cord-326673-p8qbxi57 132 35 production production NN cord-326673-p8qbxi57 132 36 . . . cord-326673-p8qbxi57 133 1 Interestingly interestingly RB cord-326673-p8qbxi57 133 2 , , , cord-326673-p8qbxi57 133 3 it -PRON- PRP cord-326673-p8qbxi57 133 4 has have VBZ cord-326673-p8qbxi57 133 5 also also RB cord-326673-p8qbxi57 133 6 been be VBN cord-326673-p8qbxi57 133 7 shown show VBN cord-326673-p8qbxi57 133 8 that that IN cord-326673-p8qbxi57 133 9 high high JJ cord-326673-p8qbxi57 133 10 titres titre NNS cord-326673-p8qbxi57 133 11 of of IN cord-326673-p8qbxi57 133 12 MDA MDA NNP cord-326673-p8qbxi57 133 13 in in IN cord-326673-p8qbxi57 133 14 piglets piglet NNS cord-326673-p8qbxi57 133 15 suppressed suppress VBD cord-326673-p8qbxi57 133 16 the the DT cord-326673-p8qbxi57 133 17 generation generation NN cord-326673-p8qbxi57 133 18 of of IN cord-326673-p8qbxi57 133 19 ' ' `` cord-326673-p8qbxi57 133 20 memory memory NN cord-326673-p8qbxi57 133 21 cells cell NNS cord-326673-p8qbxi57 133 22 ' ' POS cord-326673-p8qbxi57 133 23 following follow VBG cord-326673-p8qbxi57 133 24 vaccination vaccination NN cord-326673-p8qbxi57 133 25 against against IN cord-326673-p8qbxi57 133 26 Aujeszky Aujeszky NNP cord-326673-p8qbxi57 133 27 's 's POS cord-326673-p8qbxi57 133 28 disease disease NN cord-326673-p8qbxi57 134 1 ( ( -LRB- cord-326673-p8qbxi57 134 2 Kuiper Kuiper NNP cord-326673-p8qbxi57 134 3 et et NNP cord-326673-p8qbxi57 134 4 al al NNP cord-326673-p8qbxi57 134 5 . . NNP cord-326673-p8qbxi57 134 6 , , , cord-326673-p8qbxi57 134 7 1984 1984 CD cord-326673-p8qbxi57 134 8 ) ) -RRB- cord-326673-p8qbxi57 135 1 whereas whereas IN cord-326673-p8qbxi57 135 2 lower low JJR cord-326673-p8qbxi57 135 3 MDA MDA NNP cord-326673-p8qbxi57 135 4 titres titre NNS cord-326673-p8qbxi57 135 5 that that WDT cord-326673-p8qbxi57 135 6 still still RB cord-326673-p8qbxi57 135 7 suppressed suppress VBD cord-326673-p8qbxi57 135 8 the the DT cord-326673-p8qbxi57 135 9 formation formation NN cord-326673-p8qbxi57 135 10 of of IN cord-326673-p8qbxi57 135 11 antibody antibody NN cord-326673-p8qbxi57 135 12 permitted permit VBD cord-326673-p8qbxi57 135 13 the the DT cord-326673-p8qbxi57 135 14 generation generation NN cord-326673-p8qbxi57 135 15 of of IN cord-326673-p8qbxi57 135 16 immunological immunological JJ cord-326673-p8qbxi57 135 17 memory memory NN cord-326673-p8qbxi57 135 18 , , , cord-326673-p8qbxi57 135 19 which which WDT cord-326673-p8qbxi57 135 20 was be VBD cord-326673-p8qbxi57 135 21 apparent apparent JJ cord-326673-p8qbxi57 135 22 from from IN cord-326673-p8qbxi57 135 23 the the DT cord-326673-p8qbxi57 135 24 production production NN cord-326673-p8qbxi57 135 25 of of IN cord-326673-p8qbxi57 135 26 a a DT cord-326673-p8qbxi57 135 27 secondary secondary JJ cord-326673-p8qbxi57 135 28 - - HYPH cord-326673-p8qbxi57 135 29 type type NN cord-326673-p8qbxi57 135 30 antibody antibody NN cord-326673-p8qbxi57 135 31 response response NN cord-326673-p8qbxi57 135 32 upon upon IN cord-326673-p8qbxi57 135 33 subsequent subsequent JJ cord-326673-p8qbxi57 135 34 virus virus NN cord-326673-p8qbxi57 135 35 challenge challenge NN cord-326673-p8qbxi57 135 36 ( ( -LRB- cord-326673-p8qbxi57 135 37 van van NNP cord-326673-p8qbxi57 135 38 Oirschot Oirschot NNP cord-326673-p8qbxi57 135 39 & & CC cord-326673-p8qbxi57 135 40 de de NNP cord-326673-p8qbxi57 135 41 Leeuw Leeuw NNP cord-326673-p8qbxi57 135 42 , , , cord-326673-p8qbxi57 135 43 1985 1985 CD cord-326673-p8qbxi57 135 44 ) ) -RRB- cord-326673-p8qbxi57 135 45 . . . cord-326673-p8qbxi57 136 1 It -PRON- PRP cord-326673-p8qbxi57 136 2 is be VBZ cord-326673-p8qbxi57 136 3 also also RB cord-326673-p8qbxi57 136 4 possible possible JJ cord-326673-p8qbxi57 136 5 that that IN cord-326673-p8qbxi57 136 6 anatomical anatomical JJ cord-326673-p8qbxi57 136 7 compartments compartment NNS cord-326673-p8qbxi57 136 8 within within IN cord-326673-p8qbxi57 136 9 the the DT cord-326673-p8qbxi57 136 10 immune immune JJ cord-326673-p8qbxi57 136 11 system system NN cord-326673-p8qbxi57 136 12 are be VBP cord-326673-p8qbxi57 136 13 affected affect VBN cord-326673-p8qbxi57 136 14 variously variously RB cord-326673-p8qbxi57 136 15 by by IN cord-326673-p8qbxi57 136 16 MDA MDA NNP cord-326673-p8qbxi57 136 17 , , , cord-326673-p8qbxi57 136 18 as as IN cord-326673-p8qbxi57 136 19 has have VBZ cord-326673-p8qbxi57 136 20 been be VBN cord-326673-p8qbxi57 136 21 shown show VBN cord-326673-p8qbxi57 136 22 to to TO cord-326673-p8qbxi57 136 23 be be VB cord-326673-p8qbxi57 136 24 the the DT cord-326673-p8qbxi57 136 25 case case NN cord-326673-p8qbxi57 136 26 for for IN cord-326673-p8qbxi57 136 27 the the DT cord-326673-p8qbxi57 136 28 mucosal mucosal JJ cord-326673-p8qbxi57 136 29 immune immune JJ cord-326673-p8qbxi57 136 30 response response NN cord-326673-p8qbxi57 136 31 to to IN cord-326673-p8qbxi57 136 32 respiratory respiratory JJ cord-326673-p8qbxi57 136 33 syncytial syncytial JJ cord-326673-p8qbxi57 136 34 virus virus NN cord-326673-p8qbxi57 136 35 vaccination vaccination NN cord-326673-p8qbxi57 136 36 in in IN cord-326673-p8qbxi57 136 37 calves calf NNS cord-326673-p8qbxi57 136 38 ( ( -LRB- cord-326673-p8qbxi57 136 39 Kimman Kimman NNP cord-326673-p8qbxi57 136 40 et et NNP cord-326673-p8qbxi57 136 41 al al NNP cord-326673-p8qbxi57 136 42 . . NNP cord-326673-p8qbxi57 136 43 , , , cord-326673-p8qbxi57 136 44 1989 1989 CD cord-326673-p8qbxi57 136 45 ) ) -RRB- cord-326673-p8qbxi57 136 46 . . . cord-326673-p8qbxi57 137 1 This this DT cord-326673-p8qbxi57 137 2 study study NN cord-326673-p8qbxi57 137 3 showed show VBD cord-326673-p8qbxi57 137 4 that that IN cord-326673-p8qbxi57 137 5 a a DT cord-326673-p8qbxi57 137 6 protec protec JJ cord-326673-p8qbxi57 137 7 - - HYPH cord-326673-p8qbxi57 137 8 tive tive JJ cord-326673-p8qbxi57 137 9 mucosal mucosal JJ cord-326673-p8qbxi57 137 10 antibody antibody NN cord-326673-p8qbxi57 137 11 response response NN cord-326673-p8qbxi57 137 12 could could MD cord-326673-p8qbxi57 137 13 be be VB cord-326673-p8qbxi57 137 14 effectively effectively RB cord-326673-p8qbxi57 137 15 primed prime VBN cord-326673-p8qbxi57 137 16 by by IN cord-326673-p8qbxi57 137 17 the the DT cord-326673-p8qbxi57 137 18 local local JJ cord-326673-p8qbxi57 137 19 application application NN cord-326673-p8qbxi57 137 20 of of IN cord-326673-p8qbxi57 137 21 attenuated attenuated JJ cord-326673-p8qbxi57 137 22 virus virus NN cord-326673-p8qbxi57 137 23 in in IN cord-326673-p8qbxi57 137 24 the the DT cord-326673-p8qbxi57 137 25 face face NN cord-326673-p8qbxi57 137 26 of of IN cord-326673-p8qbxi57 137 27 MDA MDA NNP cord-326673-p8qbxi57 137 28 titres titre NNS cord-326673-p8qbxi57 137 29 that that WDT cord-326673-p8qbxi57 137 30 inhibited inhibit VBD cord-326673-p8qbxi57 137 31 all all DT cord-326673-p8qbxi57 137 32 primal primal JJ cord-326673-p8qbxi57 137 33 - - HYPH cord-326673-p8qbxi57 137 34 y y NN cord-326673-p8qbxi57 137 35 antibody antibody NN cord-326673-p8qbxi57 137 36 responses response NNS cord-326673-p8qbxi57 137 37 and and CC cord-326673-p8qbxi57 137 38 the the DT cord-326673-p8qbxi57 137 39 generation generation NN cord-326673-p8qbxi57 137 40 of of IN cord-326673-p8qbxi57 137 41 systemic systemic JJ cord-326673-p8qbxi57 137 42 antibody antibody NN cord-326673-p8qbxi57 137 43 memo memo NN cord-326673-p8qbxi57 137 44 W. W. NNP cord-326673-p8qbxi57 137 45 Thus thus RB cord-326673-p8qbxi57 137 46 , , , cord-326673-p8qbxi57 137 47 by by IN cord-326673-p8qbxi57 137 48 taking take VBG cord-326673-p8qbxi57 137 49 advantage advantage NN cord-326673-p8qbxi57 137 50 of of IN cord-326673-p8qbxi57 137 51 these these DT cord-326673-p8qbxi57 137 52 observed observe VBN cord-326673-p8qbxi57 137 53 qualitative qualitative JJ cord-326673-p8qbxi57 137 54 and and CC cord-326673-p8qbxi57 137 55 quantitative quantitative JJ cord-326673-p8qbxi57 137 56 variations variation NNS cord-326673-p8qbxi57 137 57 in in IN cord-326673-p8qbxi57 137 58 the the DT cord-326673-p8qbxi57 137 59 degree degree NN cord-326673-p8qbxi57 137 60 of of IN cord-326673-p8qbxi57 137 61 immunosuppression immunosuppression NN cord-326673-p8qbxi57 137 62 induced induce VBN cord-326673-p8qbxi57 137 63 by by IN cord-326673-p8qbxi57 137 64 MDA MDA NNP cord-326673-p8qbxi57 137 65 , , , cord-326673-p8qbxi57 137 66 it -PRON- PRP cord-326673-p8qbxi57 137 67 may may MD cord-326673-p8qbxi57 137 68 be be VB cord-326673-p8qbxi57 137 69 possible possible JJ cord-326673-p8qbxi57 137 70 to to TO cord-326673-p8qbxi57 137 71 design design VB cord-326673-p8qbxi57 137 72 vaccination vaccination NN cord-326673-p8qbxi57 137 73 su'ategies su'ategie NNS cord-326673-p8qbxi57 137 74 that that WDT cord-326673-p8qbxi57 137 75 offer offer VBP cord-326673-p8qbxi57 137 76 better well JJR cord-326673-p8qbxi57 137 77 protection protection NN cord-326673-p8qbxi57 137 78 against against IN cord-326673-p8qbxi57 137 79 infectious infectious JJ cord-326673-p8qbxi57 137 80 diseases disease NNS cord-326673-p8qbxi57 137 81 of of IN cord-326673-p8qbxi57 137 82 young young JJ cord-326673-p8qbxi57 137 83 livestock livestock NN cord-326673-p8qbxi57 137 84 . . . cord-326673-p8qbxi57 138 1 Control Control NNP cord-326673-p8qbxi57 138 2 of of IN cord-326673-p8qbxi57 138 3 FMD FMD NNP cord-326673-p8qbxi57 138 4 by by IN cord-326673-p8qbxi57 138 5 vaccination vaccination NN cord-326673-p8qbxi57 138 6 has have VBZ cord-326673-p8qbxi57 138 7 benefitted benefit VBN cord-326673-p8qbxi57 138 8 little little JJ cord-326673-p8qbxi57 138 9 fl'om fl'om NN cord-326673-p8qbxi57 138 10 the the DT cord-326673-p8qbxi57 138 11 recent recent JJ cord-326673-p8qbxi57 138 12 advances advance NNS cord-326673-p8qbxi57 138 13 in in IN cord-326673-p8qbxi57 138 14 vaccine vaccine NN cord-326673-p8qbxi57 138 15 technology technology NN cord-326673-p8qbxi57 138 16 ( ( -LRB- cord-326673-p8qbxi57 138 17 see see VB cord-326673-p8qbxi57 138 18 review review NN cord-326673-p8qbxi57 138 19 by by IN cord-326673-p8qbxi57 138 20 Kitching Kitching NNP cord-326673-p8qbxi57 138 21 , , , cord-326673-p8qbxi57 138 22 1992 1992 CD cord-326673-p8qbxi57 138 23 ) ) -RRB- cord-326673-p8qbxi57 138 24 . . . cord-326673-p8qbxi57 139 1 Iinprovements iinprovement NNS cord-326673-p8qbxi57 139 2 in in IN cord-326673-p8qbxi57 139 3 antigen antigen NN cord-326673-p8qbxi57 139 4 production production NN cord-326673-p8qbxi57 139 5 and and CC cord-326673-p8qbxi57 139 6 concentration concentration NN cord-326673-p8qbxi57 139 7 techniques technique NNS cord-326673-p8qbxi57 139 8 have have VBP cord-326673-p8qbxi57 139 9 not not RB cord-326673-p8qbxi57 139 10 resulted result VBN cord-326673-p8qbxi57 139 11 in in IN cord-326673-p8qbxi57 139 12 significantly significantly RB cord-326673-p8qbxi57 139 13 better well JJR cord-326673-p8qbxi57 139 14 vaccines vaccine NNS cord-326673-p8qbxi57 139 15 , , , cord-326673-p8qbxi57 139 16 and and CC cord-326673-p8qbxi57 139 17 FMD FMD NNP cord-326673-p8qbxi57 139 18 remains remain VBZ cord-326673-p8qbxi57 139 19 a a DT cord-326673-p8qbxi57 139 20 disease disease NN cord-326673-p8qbxi57 139 21 that that WDT cord-326673-p8qbxi57 139 22 can can MD cord-326673-p8qbxi57 139 23 not not RB cord-326673-p8qbxi57 139 24 be be VB cord-326673-p8qbxi57 139 25 controlled control VBN cord-326673-p8qbxi57 139 26 by by IN cord-326673-p8qbxi57 139 27 vaccination vaccination NN cord-326673-p8qbxi57 139 28 alone alone RB cord-326673-p8qbxi57 139 29 . . . cord-326673-p8qbxi57 140 1 The the DT cord-326673-p8qbxi57 140 2 interference interference NN cord-326673-p8qbxi57 140 3 by by IN cord-326673-p8qbxi57 140 4 MDA MDA NNP cord-326673-p8qbxi57 140 5 in in IN cord-326673-p8qbxi57 140 6 tile tile NN cord-326673-p8qbxi57 140 7 active active JJ cord-326673-p8qbxi57 140 8 immunization immunization NN cord-326673-p8qbxi57 140 9 of of IN cord-326673-p8qbxi57 140 10 young young JJ cord-326673-p8qbxi57 140 11 stock stock NN cord-326673-p8qbxi57 140 12 merely merely RB cord-326673-p8qbxi57 140 13 makes make VBZ cord-326673-p8qbxi57 140 14 control control NN cord-326673-p8qbxi57 140 15 of of IN cord-326673-p8qbxi57 140 16 the the DT cord-326673-p8qbxi57 140 17 disease disease NN cord-326673-p8qbxi57 140 18 even even RB cord-326673-p8qbxi57 140 19 more more RBR cord-326673-p8qbxi57 140 20 difficult difficult JJ cord-326673-p8qbxi57 140 21 . . . cord-326673-p8qbxi57 141 1 Cah Cah NNP cord-326673-p8qbxi57 141 2 , , , cord-326673-p8qbxi57 141 3 es es NNP cord-326673-p8qbxi57 141 4 with with IN cord-326673-p8qbxi57 141 5 declining decline VBG cord-326673-p8qbxi57 141 6 MDA MDA NNP cord-326673-p8qbxi57 141 7 become become VBP cord-326673-p8qbxi57 141 8 susceptible susceptible JJ cord-326673-p8qbxi57 141 9 to to IN cord-326673-p8qbxi57 141 10 infection infection NN cord-326673-p8qbxi57 141 11 with with IN cord-326673-p8qbxi57 141 12 live live JJ cord-326673-p8qbxi57 141 13 virus virus NN cord-326673-p8qbxi57 141 14 before before IN cord-326673-p8qbxi57 141 15 they -PRON- PRP cord-326673-p8qbxi57 141 16 are be VBP cord-326673-p8qbxi57 141 17 able able JJ cord-326673-p8qbxi57 141 18 to to TO cord-326673-p8qbxi57 141 19 respond respond VB cord-326673-p8qbxi57 141 20 to to IN cord-326673-p8qbxi57 141 21 an an DT cord-326673-p8qbxi57 141 22 inactivated inactivate VBN cord-326673-p8qbxi57 141 23 vaccine vaccine NN cord-326673-p8qbxi57 141 24 . . . cord-326673-p8qbxi57 142 1 This this DT cord-326673-p8qbxi57 142 2 observation observation NN cord-326673-p8qbxi57 142 3 suggests suggest VBZ cord-326673-p8qbxi57 142 4 that that IN cord-326673-p8qbxi57 142 5 the the DT cord-326673-p8qbxi57 142 6 ) ) -RRB- cord-326673-p8qbxi57 142 7 , , , cord-326673-p8qbxi57 142 8 would would MD cord-326673-p8qbxi57 142 9 also also RB cord-326673-p8qbxi57 142 10 respond respond VB cord-326673-p8qbxi57 142 11 to to IN cord-326673-p8qbxi57 142 12 a a DT cord-326673-p8qbxi57 142 13 live live JJ cord-326673-p8qbxi57 142 14 vaccine vaccine NN cord-326673-p8qbxi57 142 15 at at IN cord-326673-p8qbxi57 142 16 a a DT cord-326673-p8qbxi57 142 17 higher high JJR cord-326673-p8qbxi57 142 18 serum serum NN cord-326673-p8qbxi57 142 19 level level NN cord-326673-p8qbxi57 142 20 of of IN cord-326673-p8qbxi57 142 21 MDA MDA NNP cord-326673-p8qbxi57 142 22 than than IN cord-326673-p8qbxi57 142 23 they -PRON- PRP cord-326673-p8qbxi57 142 24 would would MD cord-326673-p8qbxi57 142 25 using use VBG cord-326673-p8qbxi57 142 26 a a DT cord-326673-p8qbxi57 142 27 dead dead JJ cord-326673-p8qbxi57 142 28 vaccine vaccine NN cord-326673-p8qbxi57 142 29 . . . cord-326673-p8qbxi57 143 1 However however RB cord-326673-p8qbxi57 143 2 , , , cord-326673-p8qbxi57 143 3 previous previous JJ cord-326673-p8qbxi57 143 4 attempts attempt NNS cord-326673-p8qbxi57 143 5 to to TO cord-326673-p8qbxi57 143 6 develop develop VB cord-326673-p8qbxi57 143 7 a a DT cord-326673-p8qbxi57 143 8 live live JJ cord-326673-p8qbxi57 143 9 attenuated attenuate VBN cord-326673-p8qbxi57 143 10 FMD FMD NNP cord-326673-p8qbxi57 143 11 vaccine vaccine NN cord-326673-p8qbxi57 143 12 were be VBD cord-326673-p8qbxi57 143 13 unsuccessful unsuccessful JJ cord-326673-p8qbxi57 143 14 as as IN cord-326673-p8qbxi57 143 15 the the DT cord-326673-p8qbxi57 143 16 virus virus NN cord-326673-p8qbxi57 143 17 quickly quickly RB cord-326673-p8qbxi57 143 18 reverted revert VBD cord-326673-p8qbxi57 143 19 to to IN cord-326673-p8qbxi57 143 20 virulence virulence NN cord-326673-p8qbxi57 143 21 . . . cord-326673-p8qbxi57 144 1 The the DT cord-326673-p8qbxi57 144 2 genome genome NN cord-326673-p8qbxi57 144 3 sequences sequence NNS cord-326673-p8qbxi57 144 4 associated associate VBN cord-326673-p8qbxi57 144 5 with with IN cord-326673-p8qbxi57 144 6 virulence virulence NN cord-326673-p8qbxi57 144 7 of of IN cord-326673-p8qbxi57 144 8 FMD FMD NNP cord-326673-p8qbxi57 144 9 virus virus NN cord-326673-p8qbxi57 144 10 are be VBP cord-326673-p8qbxi57 144 11 not not RB cord-326673-p8qbxi57 144 12 known know VBN cord-326673-p8qbxi57 144 13 , , , cord-326673-p8qbxi57 144 14 but but CC cord-326673-p8qbxi57 144 15 stocks stock NNS cord-326673-p8qbxi57 144 16 of of IN cord-326673-p8qbxi57 144 17 the the DT cord-326673-p8qbxi57 144 18 original original JJ cord-326673-p8qbxi57 144 19 attenuated attenuated JJ cord-326673-p8qbxi57 144 20 vaccine vaccine NN cord-326673-p8qbxi57 144 21 still still RB cord-326673-p8qbxi57 144 22 exist exist VBP cord-326673-p8qbxi57 144 23 . . . cord-326673-p8qbxi57 145 1 If if IN cord-326673-p8qbxi57 145 2 it -PRON- PRP cord-326673-p8qbxi57 145 3 was be VBD cord-326673-p8qbxi57 145 4 possible possible JJ cord-326673-p8qbxi57 145 5 to to TO cord-326673-p8qbxi57 145 6 fix fix VB cord-326673-p8qbxi57 145 7 the the DT cord-326673-p8qbxi57 145 8 mutations mutation NNS cord-326673-p8qbxi57 145 9 responsible responsible JJ cord-326673-p8qbxi57 145 10 for for IN cord-326673-p8qbxi57 145 11 attenuation attenuation NN cord-326673-p8qbxi57 145 12 of of IN cord-326673-p8qbxi57 145 13 FMD FMD NNP cord-326673-p8qbxi57 145 14 virus virus NN cord-326673-p8qbxi57 145 15 , , , cord-326673-p8qbxi57 145 16 vaccination vaccination NN cord-326673-p8qbxi57 145 17 with with IN cord-326673-p8qbxi57 145 18 live live JJ cord-326673-p8qbxi57 145 19 virus virus NN cord-326673-p8qbxi57 145 20 could could MD cord-326673-p8qbxi57 145 21 again again RB cord-326673-p8qbxi57 145 22 become become VB cord-326673-p8qbxi57 145 23 an an DT cord-326673-p8qbxi57 145 24 option option NN cord-326673-p8qbxi57 145 25 , , , cord-326673-p8qbxi57 145 26 although although IN cord-326673-p8qbxi57 145 27 the the DT cord-326673-p8qbxi57 145 28 reputation reputation NN cord-326673-p8qbxi57 145 29 that that WDT cord-326673-p8qbxi57 145 30 live live VBP cord-326673-p8qbxi57 145 31 FMD FMD NNP cord-326673-p8qbxi57 145 32 vaccines vaccine NNS cord-326673-p8qbxi57 145 33 have have VBP cord-326673-p8qbxi57 145 34 acquired acquire VBN cord-326673-p8qbxi57 145 35 may may MD cord-326673-p8qbxi57 145 36 exclude exclude VB cord-326673-p8qbxi57 145 37 their -PRON- PRP$ cord-326673-p8qbxi57 145 38 use use NN cord-326673-p8qbxi57 145 39 under under IN cord-326673-p8qbxi57 145 40 any any DT cord-326673-p8qbxi57 145 41 circumstances circumstance NNS cord-326673-p8qbxi57 145 42 . . . cord-326673-p8qbxi57 146 1 If if IN cord-326673-p8qbxi57 146 2 a a DT cord-326673-p8qbxi57 146 3 live live JJ cord-326673-p8qbxi57 146 4 vaccine vaccine NN cord-326673-p8qbxi57 146 5 can can MD cord-326673-p8qbxi57 146 6 partially partially RB cord-326673-p8qbxi57 146 7 overcome overcome VB cord-326673-p8qbxi57 146 8 interference interference NN cord-326673-p8qbxi57 146 9 by by IN cord-326673-p8qbxi57 146 10 MDA MDA NNP cord-326673-p8qbxi57 146 11 , , , cord-326673-p8qbxi57 146 12 an an DT cord-326673-p8qbxi57 146 13 alternative alternative JJ cord-326673-p8qbxi57 146 14 approach approach NN cord-326673-p8qbxi57 146 15 might may MD cord-326673-p8qbxi57 146 16 be be VB cord-326673-p8qbxi57 146 17 to to TO cord-326673-p8qbxi57 146 18 insert insert VB cord-326673-p8qbxi57 146 19 FMD FMD NNP cord-326673-p8qbxi57 146 20 virus virus NN cord-326673-p8qbxi57 146 21 genes gene NNS cord-326673-p8qbxi57 146 22 into into IN cord-326673-p8qbxi57 146 23 a a DT cord-326673-p8qbxi57 146 24 live live JJ cord-326673-p8qbxi57 146 25 vector vector NN cord-326673-p8qbxi57 146 26 . . . cord-326673-p8qbxi57 147 1 The the DT cord-326673-p8qbxi57 147 2 glycoprotein glycoprotein NN cord-326673-p8qbxi57 147 3 gene gene NN cord-326673-p8qbxi57 147 4 of of IN cord-326673-p8qbxi57 147 5 rabies rabies NN cord-326673-p8qbxi57 147 6 virus virus NN cord-326673-p8qbxi57 147 7 has have VBZ cord-326673-p8qbxi57 147 8 been be VBN cord-326673-p8qbxi57 147 9 placed place VBN cord-326673-p8qbxi57 147 10 in in IN cord-326673-p8qbxi57 147 11 the the DT cord-326673-p8qbxi57 147 12 vaccinia vaccinia NN cord-326673-p8qbxi57 147 13 virus virus NN cord-326673-p8qbxi57 147 14 genome genome NN cord-326673-p8qbxi57 147 15 ( ( -LRB- cord-326673-p8qbxi57 147 16 Pastoret Pastoret NNP cord-326673-p8qbxi57 147 17 el el NNP cord-326673-p8qbxi57 147 18 al al NNP cord-326673-p8qbxi57 147 19 . . NNP cord-326673-p8qbxi57 147 20 , , , cord-326673-p8qbxi57 147 21 1992 1992 CD cord-326673-p8qbxi57 147 22 ) ) -RRB- cord-326673-p8qbxi57 147 23 and and CC cord-326673-p8qbxi57 147 24 the the DT cord-326673-p8qbxi57 147 25 F F NNP cord-326673-p8qbxi57 147 26 and and CC cord-326673-p8qbxi57 147 27 H H NNP cord-326673-p8qbxi57 147 28 genes gene NNS cord-326673-p8qbxi57 147 29 of of IN cord-326673-p8qbxi57 147 30 rinderpest rinderpest NN cord-326673-p8qbxi57 147 31 virus virus NN cord-326673-p8qbxi57 147 32 have have VBP cord-326673-p8qbxi57 147 33 been be VBN cord-326673-p8qbxi57 147 34 placed place VBN cord-326673-p8qbxi57 147 35 in in IN cord-326673-p8qbxi57 147 36 the the DT cord-326673-p8qbxi57 147 37 genomes genome NNS cord-326673-p8qbxi57 147 38 ofvaccinia ofvaccinia NNP cord-326673-p8qbxi57 147 39 virus virus NN cord-326673-p8qbxi57 147 40 ( ( -LRB- cord-326673-p8qbxi57 147 41 Yihna Yihna NNP cord-326673-p8qbxi57 147 42 el el NNP cord-326673-p8qbxi57 147 43 aL aL NNP cord-326673-p8qbxi57 147 44 , , , cord-326673-p8qbxi57 147 45 1988 1988 CD cord-326673-p8qbxi57 147 46 ) ) -RRB- cord-326673-p8qbxi57 147 47 and and CC cord-326673-p8qbxi57 147 48 capripoxvirus capripoxvirus NNP cord-326673-p8qbxi57 147 49 ( ( -LRB- cord-326673-p8qbxi57 147 50 Romero Romero NNP cord-326673-p8qbxi57 147 51 et et NNP cord-326673-p8qbxi57 147 52 aL aL NNP cord-326673-p8qbxi57 147 53 , , , cord-326673-p8qbxi57 147 54 1993 1993 CD cord-326673-p8qbxi57 147 55 ) ) -RRB- cord-326673-p8qbxi57 147 56 to to TO cord-326673-p8qbxi57 147 57 produce produce VB cord-326673-p8qbxi57 147 58 effective effective JJ cord-326673-p8qbxi57 147 59 live live JJ cord-326673-p8qbxi57 147 60 vaccines vaccine NNS cord-326673-p8qbxi57 147 61 against against IN cord-326673-p8qbxi57 147 62 rabies rabies NN cord-326673-p8qbxi57 147 63 and and CC cord-326673-p8qbxi57 147 64 rinderpest rinderpest NN cord-326673-p8qbxi57 147 65 , , , cord-326673-p8qbxi57 147 66 respectively respectively RB cord-326673-p8qbxi57 147 67 . . . cord-326673-p8qbxi57 148 1 These these DT cord-326673-p8qbxi57 148 2 recombinant recombinant JJ cord-326673-p8qbxi57 148 3 vaccines vaccine NNS cord-326673-p8qbxi57 148 4 will will MD cord-326673-p8qbxi57 148 5 replicate replicate VB cord-326673-p8qbxi57 148 6 in in IN cord-326673-p8qbxi57 148 7 the the DT cord-326673-p8qbxi57 148 8 presence presence NN cord-326673-p8qbxi57 148 9 of of IN cord-326673-p8qbxi57 148 10 MDA MDA NNP cord-326673-p8qbxi57 148 11 to to IN cord-326673-p8qbxi57 148 12 rabies rabie NNS cord-326673-p8qbxi57 148 13 or or CC cord-326673-p8qbxi57 148 14 rinderpest rinderpest NN cord-326673-p8qbxi57 148 15 as as IN cord-326673-p8qbxi57 148 16 there there EX cord-326673-p8qbxi57 148 17 ufill ufill VBP cord-326673-p8qbxi57 148 18 be be VB cord-326673-p8qbxi57 148 19 no no DT cord-326673-p8qbxi57 148 20 inhibition inhibition NN cord-326673-p8qbxi57 148 21 of of IN cord-326673-p8qbxi57 148 22 the the DT cord-326673-p8qbxi57 148 23 pox pox NN cord-326673-p8qbxi57 148 24 virus virus NN cord-326673-p8qbxi57 148 25 vector vector NN cord-326673-p8qbxi57 148 26 . . . cord-326673-p8qbxi57 149 1 Initial initial JJ cord-326673-p8qbxi57 149 2 attempts attempt NNS cord-326673-p8qbxi57 149 3 to to TO cord-326673-p8qbxi57 149 4 do do VB cord-326673-p8qbxi57 149 5 the the DT cord-326673-p8qbxi57 149 6 same same JJ cord-326673-p8qbxi57 149 7 for for IN cord-326673-p8qbxi57 149 8 FMD FMD NNP cord-326673-p8qbxi57 149 9 xdrus xdrus NNP cord-326673-p8qbxi57 149 10 have have VBP cord-326673-p8qbxi57 149 11 so so RB cord-326673-p8qbxi57 149 12 far far RB cord-326673-p8qbxi57 149 13 been be VBN cord-326673-p8qbxi57 149 14 unsuccessful unsuccessful JJ cord-326673-p8qbxi57 149 15 . . . cord-326673-p8qbxi57 150 1 Similarly similarly RB cord-326673-p8qbxi57 150 2 , , , cord-326673-p8qbxi57 150 3 peptide peptide JJ cord-326673-p8qbxi57 150 4 vaccines vaccine NNS cord-326673-p8qbxi57 150 5 have have VBP cord-326673-p8qbxi57 150 6 not not RB cord-326673-p8qbxi57 150 7 replaced replace VBN cord-326673-p8qbxi57 150 8 conventional conventional JJ cord-326673-p8qbxi57 150 9 FMD FMD NNP cord-326673-p8qbxi57 150 10 vaccines vaccine NNS cord-326673-p8qbxi57 150 11 in in IN cord-326673-p8qbxi57 150 12 spite spite NN cord-326673-p8qbxi57 150 13 of of IN cord-326673-p8qbxi57 150 14 considerable considerable JJ cord-326673-p8qbxi57 150 15 research research NN cord-326673-p8qbxi57 150 16 effort effort NN cord-326673-p8qbxi57 150 17 . . . cord-326673-p8qbxi57 151 1 This this DT cord-326673-p8qbxi57 151 2 has have VBZ cord-326673-p8qbxi57 151 3 in in IN cord-326673-p8qbxi57 151 4 part part NN cord-326673-p8qbxi57 151 5 been be VBN cord-326673-p8qbxi57 151 6 blamed blame VBN cord-326673-p8qbxi57 151 7 on on IN cord-326673-p8qbxi57 151 8 their -PRON- PRP$ cord-326673-p8qbxi57 151 9 failure failure NN cord-326673-p8qbxi57 151 10 to to TO cord-326673-p8qbxi57 151 11 stimulate stimulate VB cord-326673-p8qbxi57 151 12 appropriate appropriate JJ cord-326673-p8qbxi57 151 13 B b NN cord-326673-p8qbxi57 151 14 and and CC cord-326673-p8qbxi57 151 15 T t NN cord-326673-p8qbxi57 151 16 cell cell NN cord-326673-p8qbxi57 151 17 populations population NNS cord-326673-p8qbxi57 151 18 . . . cord-326673-p8qbxi57 152 1 If if IN cord-326673-p8qbxi57 152 2 , , , cord-326673-p8qbxi57 152 3 as as IN cord-326673-p8qbxi57 152 4 has have VBZ cord-326673-p8qbxi57 152 5 been be VBN cord-326673-p8qbxi57 152 6 suggested suggest VBN cord-326673-p8qbxi57 152 7 , , , cord-326673-p8qbxi57 152 8 MDA MDA NNP cord-326673-p8qbxi57 152 9 selectively selectively RB cord-326673-p8qbxi57 152 10 suppresses suppress VBZ cord-326673-p8qbxi57 152 11 antigen antigen NN cord-326673-p8qbxi57 152 12 - - HYPH cord-326673-p8qbxi57 152 13 specific specific JJ cord-326673-p8qbxi57 152 14 responses response NNS cord-326673-p8qbxi57 152 15 , , , cord-326673-p8qbxi57 152 16 there there EX cord-326673-p8qbxi57 152 17 would would MD cord-326673-p8qbxi57 152 18 be be VB cord-326673-p8qbxi57 152 19 little little JJ cord-326673-p8qbxi57 152 20 potential potential NN cord-326673-p8qbxi57 152 21 for for IN cord-326673-p8qbxi57 152 22 peptide peptide JJ cord-326673-p8qbxi57 152 23 vaccines vaccine NNS cord-326673-p8qbxi57 152 24 to to TO cord-326673-p8qbxi57 152 25 overcome overcome VB cord-326673-p8qbxi57 152 26 MDA MDA NNP cord-326673-p8qbxi57 152 27 . . . cord-326673-p8qbxi57 153 1 However however RB cord-326673-p8qbxi57 153 2 , , , cord-326673-p8qbxi57 153 3 Lipford Lipford NNP cord-326673-p8qbxi57 153 4 et et NNP cord-326673-p8qbxi57 153 5 al al NNP cord-326673-p8qbxi57 153 6 . . . cord-326673-p8qbxi57 154 1 ( ( -LRB- cord-326673-p8qbxi57 154 2 1994 1994 CD cord-326673-p8qbxi57 154 3 ) ) -RRB- cord-326673-p8qbxi57 154 4 have have VBP cord-326673-p8qbxi57 154 5 recently recently RB cord-326673-p8qbxi57 154 6 reported report VBN cord-326673-p8qbxi57 154 7 the the DT cord-326673-p8qbxi57 154 8 development development NN cord-326673-p8qbxi57 154 9 of of IN cord-326673-p8qbxi57 154 10 immunostimulating immunostimulate VBG cord-326673-p8qbxi57 154 11 complexes complex NNS cord-326673-p8qbxi57 154 12 ( ( -LRB- cord-326673-p8qbxi57 154 13 ISCOMs iscom NNS cord-326673-p8qbxi57 154 14 ) ) -RRB- cord-326673-p8qbxi57 154 15 containing contain VBG cord-326673-p8qbxi57 154 16 lipids lipid NNS cord-326673-p8qbxi57 154 17 and and CC cord-326673-p8qbxi57 154 18 the the DT cord-326673-p8qbxi57 154 19 saponin saponin NN cord-326673-p8qbxi57 154 20 Quil Quil NNP cord-326673-p8qbxi57 154 21 A A NNP cord-326673-p8qbxi57 154 22 , , , cord-326673-p8qbxi57 154 23 which which WDT cord-326673-p8qbxi57 154 24 induce induce VBP cord-326673-p8qbxi57 154 25 antigen antigen NN cord-326673-p8qbxi57 154 26 - - HYPH cord-326673-p8qbxi57 154 27 specific specific JJ cord-326673-p8qbxi57 154 28 cytolytic cytolytic FW cord-326673-p8qbxi57 154 29 T t NN cord-326673-p8qbxi57 154 30 cells cell NNS cord-326673-p8qbxi57 154 31 . . . cord-326673-p8qbxi57 155 1 The the DT cord-326673-p8qbxi57 155 2 incorporation incorporation NN cord-326673-p8qbxi57 155 3 of of IN cord-326673-p8qbxi57 155 4 FMD FMD NNP cord-326673-p8qbxi57 155 5 xdrus xdrus NNP cord-326673-p8qbxi57 155 6 antigens antigen NNS cord-326673-p8qbxi57 155 7 into into IN cord-326673-p8qbxi57 155 8 an an DT cord-326673-p8qbxi57 155 9 ISCOM ISCOM NNP cord-326673-p8qbxi57 155 10 could could MD cord-326673-p8qbxi57 155 11 improve improve VB cord-326673-p8qbxi57 155 12 peptide peptide JJ cord-326673-p8qbxi57 155 13 immunogenicity immunogenicity NN cord-326673-p8qbxi57 155 14 . . . cord-326673-p8qbxi57 156 1 There there EX cord-326673-p8qbxi57 156 2 is be VBZ cord-326673-p8qbxi57 156 3 at at IN cord-326673-p8qbxi57 156 4 present present JJ cord-326673-p8qbxi57 156 5 no no DT cord-326673-p8qbxi57 156 6 completely completely RB cord-326673-p8qbxi57 156 7 effective effective JJ cord-326673-p8qbxi57 156 8 strategy strategy NN cord-326673-p8qbxi57 156 9 to to TO cord-326673-p8qbxi57 156 10 protect protect VB cord-326673-p8qbxi57 156 11 young young JJ cord-326673-p8qbxi57 156 12 stock stock NN cord-326673-p8qbxi57 156 13 against against IN cord-326673-p8qbxi57 156 14 FMD FMD NNP cord-326673-p8qbxi57 156 15 by by IN cord-326673-p8qbxi57 156 16 vaccination vaccination NN cord-326673-p8qbxi57 156 17 in in IN cord-326673-p8qbxi57 156 18 situations situation NNS cord-326673-p8qbxi57 156 19 in in IN cord-326673-p8qbxi57 156 20 which which WDT cord-326673-p8qbxi57 156 21 FMD FMD NNP cord-326673-p8qbxi57 156 22 is be VBZ cord-326673-p8qbxi57 156 23 endemic endemic JJ cord-326673-p8qbxi57 156 24 . . . cord-326673-p8qbxi57 157 1 Only only RB cord-326673-p8qbxi57 157 2 by by IN cord-326673-p8qbxi57 157 3 isolating isolate VBG cord-326673-p8qbxi57 157 4 them -PRON- PRP cord-326673-p8qbxi57 157 5 completely completely RB cord-326673-p8qbxi57 157 6 from from IN cord-326673-p8qbxi57 157 7 challenge challenge NN cord-326673-p8qbxi57 157 8 with with IN cord-326673-p8qbxi57 157 9 field field NN cord-326673-p8qbxi57 157 10 virus virus NN cord-326673-p8qbxi57 157 11 until until IN cord-326673-p8qbxi57 157 12 their -PRON- PRP$ cord-326673-p8qbxi57 157 13 MDA MDA NNP cord-326673-p8qbxi57 157 14 has have VBZ cord-326673-p8qbxi57 157 15 declined decline VBN cord-326673-p8qbxi57 157 16 sufficiently sufficiently RB cord-326673-p8qbxi57 157 17 for for IN cord-326673-p8qbxi57 157 18 them -PRON- PRP cord-326673-p8qbxi57 157 19 to to TO cord-326673-p8qbxi57 157 20 respond respond VB cord-326673-p8qbxi57 157 21 to to IN cord-326673-p8qbxi57 157 22 conventional conventional JJ cord-326673-p8qbxi57 157 23 vaccines vaccine NNS cord-326673-p8qbxi57 157 24 can can MD cord-326673-p8qbxi57 157 25 disease disease NN cord-326673-p8qbxi57 157 26 be be VB cord-326673-p8qbxi57 157 27 prevented prevent VBN cord-326673-p8qbxi57 157 28 , , , cord-326673-p8qbxi57 157 29 but but CC cord-326673-p8qbxi57 157 30 such such PDT cord-326673-p8qbxi57 157 31 an an DT cord-326673-p8qbxi57 157 32 approach approach NN cord-326673-p8qbxi57 157 33 in in IN cord-326673-p8qbxi57 157 34 many many JJ cord-326673-p8qbxi57 157 35 countries country NNS cord-326673-p8qbxi57 157 36 may may MD cord-326673-p8qbxi57 157 37 be be VB cord-326673-p8qbxi57 157 38 too too RB cord-326673-p8qbxi57 157 39 expensive expensive JJ cord-326673-p8qbxi57 157 40 to to TO cord-326673-p8qbxi57 157 41 contemplate contemplate VB cord-326673-p8qbxi57 157 42 . . . cord-326673-p8qbxi57 158 1 The the DT cord-326673-p8qbxi57 158 2 serological serological JJ cord-326673-p8qbxi57 158 3 response response NN cord-326673-p8qbxi57 158 4 of of IN cord-326673-p8qbxi57 158 5 young young JJ cord-326673-p8qbxi57 158 6 dogs dog NNS cord-326673-p8qbxi57 158 7 to to IN cord-326673-p8qbxi57 158 8 the the DT cord-326673-p8qbxi57 158 9 Flul Flul NNP cord-326673-p8qbxi57 158 10 T T NNP cord-326673-p8qbxi57 158 11 LEP LEP NNP cord-326673-p8qbxi57 158 12 strain strain NN cord-326673-p8qbxi57 158 13 of of IN cord-326673-p8qbxi57 158 14 rabies rabies NN cord-326673-p8qbxi57 158 15 virus virus NN cord-326673-p8qbxi57 158 16 vaccine vaccine NN cord-326673-p8qbxi57 158 17 . . . cord-326673-p8qbxi57 159 1 Veterina Veterina NNP cord-326673-p8qbxi57 159 2 O O NNP cord-326673-p8qbxi57 159 3 Protection Protection NNP cord-326673-p8qbxi57 159 4 of of IN cord-326673-p8qbxi57 159 5 young young JJ cord-326673-p8qbxi57 159 6 animals animal NNS cord-326673-p8qbxi57 159 7 against against IN cord-326673-p8qbxi57 159 8 foot foot NN cord-326673-p8qbxi57 159 9 and and CC cord-326673-p8qbxi57 159 10 mouth mouth NN cord-326673-p8qbxi57 159 11 disease disease NN cord-326673-p8qbxi57 159 12 Host Host NNP cord-326673-p8qbxi57 159 13 defence defence NN cord-326673-p8qbxi57 159 14 in in IN cord-326673-p8qbxi57 159 15 the the DT cord-326673-p8qbxi57 159 16 newborn newborn JJ cord-326673-p8qbxi57 159 17 animal animal NN cord-326673-p8qbxi57 159 18 Immnnologic Immnnologic NNP cord-326673-p8qbxi57 159 19 responses response NNS cord-326673-p8qbxi57 159 20 in in IN cord-326673-p8qbxi57 159 21 colostrum colostrum NN cord-326673-p8qbxi57 159 22 - - HYPH cord-326673-p8qbxi57 159 23 fed feed VBN cord-326673-p8qbxi57 159 24 and and CC cord-326673-p8qbxi57 159 25 colostrum colostrum NN cord-326673-p8qbxi57 159 26 - - HYPH cord-326673-p8qbxi57 159 27 deprived deprive VBN cord-326673-p8qbxi57 159 28 calves calf NNS cord-326673-p8qbxi57 159 29 Half half RB cord-326673-p8qbxi57 159 30 - - HYPH cord-326673-p8qbxi57 159 31 lives life NNS cord-326673-p8qbxi57 159 32 of of IN cord-326673-p8qbxi57 159 33 immunoglobulins immunoglobulin NNS cord-326673-p8qbxi57 159 34 IgG IgG NNP cord-326673-p8qbxi57 159 35 , , , cord-326673-p8qbxi57 159 36 IgA IgA NNP cord-326673-p8qbxi57 159 37 and and CC cord-326673-p8qbxi57 159 38 IgM IgM NNP cord-326673-p8qbxi57 159 39 in in IN cord-326673-p8qbxi57 159 40 the the DT cord-326673-p8qbxi57 159 41 sermn sermn NNP cord-326673-p8qbxi57 159 42 of of IN cord-326673-p8qbxi57 159 43 new new RB cord-326673-p8qbxi57 159 44 - - HYPH cord-326673-p8qbxi57 159 45 born bear VBN cord-326673-p8qbxi57 159 46 pigs pig NNS cord-326673-p8qbxi57 159 47 . . . cord-326673-p8qbxi57 160 1 hnmunolo~ hnmunolo~ NNP cord-326673-p8qbxi57 160 2 The the DT cord-326673-p8qbxi57 160 3 Immoral immoral JJ cord-326673-p8qbxi57 160 4 immune immune JJ cord-326673-p8qbxi57 160 5 response response NN cord-326673-p8qbxi57 160 6 of of IN cord-326673-p8qbxi57 160 7 young young JJ cord-326673-p8qbxi57 160 8 animals animal NNS cord-326673-p8qbxi57 160 9 to to IN cord-326673-p8qbxi57 160 10 foot foot NN cord-326673-p8qbxi57 160 11 - - HYPH cord-326673-p8qbxi57 160 12 and and CC cord-326673-p8qbxi57 160 13 - - HYPH cord-326673-p8qbxi57 160 14 mouth mouth NN cord-326673-p8qbxi57 160 15 disease disease NN cord-326673-p8qbxi57 160 16 vaccination vaccination NN cord-326673-p8qbxi57 160 17 . . . cord-326673-p8qbxi57 161 1 Foot foot NN cord-326673-p8qbxi57 161 2 - - HYPH cord-326673-p8qbxi57 161 3 and and CC cord-326673-p8qbxi57 161 4 - - HYPH cord-326673-p8qbxi57 161 5 Mouth Mouth NNP cord-326673-p8qbxi57 161 6 Disease Disease NNP cord-326673-p8qbxi57 161 7 Bulletin Bulletin NNP cord-326673-p8qbxi57 161 8 Effect Effect NNP cord-326673-p8qbxi57 161 9 of of IN cord-326673-p8qbxi57 161 10 the the DT cord-326673-p8qbxi57 161 11 sow sow NN cord-326673-p8qbxi57 161 12 vaccination vaccination NN cord-326673-p8qbxi57 161 13 regimen regimen NN cord-326673-p8qbxi57 161 14 on on IN cord-326673-p8qbxi57 161 15 the the DT cord-326673-p8qbxi57 161 16 decay decay NN cord-326673-p8qbxi57 161 17 rate rate NN cord-326673-p8qbxi57 161 18 of of IN cord-326673-p8qbxi57 161 19 maternally maternally RB cord-326673-p8qbxi57 161 20 derived derive VBN cord-326673-p8qbxi57 161 21 foot foot NN cord-326673-p8qbxi57 161 22 and and CC cord-326673-p8qbxi57 161 23 mouth mouth NN cord-326673-p8qbxi57 161 24 disease disease NN cord-326673-p8qbxi57 161 25 antibodies antibody NNS cord-326673-p8qbxi57 161 26 in in IN cord-326673-p8qbxi57 161 27 piglets piglet NNS cord-326673-p8qbxi57 162 1 Response response NN cord-326673-p8qbxi57 162 2 of of IN cord-326673-p8qbxi57 162 3 young young JJ cord-326673-p8qbxi57 162 4 pigs pig NNS cord-326673-p8qbxi57 162 5 to to IN cord-326673-p8qbxi57 162 6 FMD FMD NNP cord-326673-p8qbxi57 162 7 oil oil NN cord-326673-p8qbxi57 162 8 emulsion emulsion NN cord-326673-p8qbxi57 162 9 vaccination vaccination NN cord-326673-p8qbxi57 162 10 in in IN cord-326673-p8qbxi57 162 11 the the DT cord-326673-p8qbxi57 162 12 presence presence NN cord-326673-p8qbxi57 162 13 and and CC cord-326673-p8qbxi57 162 14 absence absence NN cord-326673-p8qbxi57 162 15 of of IN cord-326673-p8qbxi57 162 16 maternally maternally RB cord-326673-p8qbxi57 162 17 derived derive VBN cord-326673-p8qbxi57 162 18 neutralising neutralise VBG cord-326673-p8qbxi57 162 19 antibodies antibody NNS cord-326673-p8qbxi57 162 20 Maternal Maternal NNP cord-326673-p8qbxi57 162 21 T T NNP cord-326673-p8qbxi57 162 22 cells cell NNS cord-326673-p8qbxi57 162 23 of of IN cord-326673-p8qbxi57 162 24 immunised immunised JJ cord-326673-p8qbxi57 162 25 pregnant pregnant JJ cord-326673-p8qbxi57 162 26 mice mouse NNS cord-326673-p8qbxi57 162 27 induce induce VB cord-326673-p8qbxi57 162 28 imnmne imnmne NN cord-326673-p8qbxi57 162 29 suppression suppression NN cord-326673-p8qbxi57 162 30 in in IN cord-326673-p8qbxi57 162 31 their -PRON- PRP$ cord-326673-p8qbxi57 162 32 offspring offspring NN cord-326673-p8qbxi57 162 33 Enzylne Enzylne NNP cord-326673-p8qbxi57 162 34 - - HYPH cord-326673-p8qbxi57 162 35 linked link VBN cord-326673-p8qbxi57 162 36 immunosorbent immunosorbent JJ cord-326673-p8qbxi57 162 37 assay assay NN cord-326673-p8qbxi57 162 38 ( ( -LRB- cord-326673-p8qbxi57 162 39 ELISA ELISA NNP cord-326673-p8qbxi57 162 40 ) ) -RRB- cord-326673-p8qbxi57 162 41 for for IN cord-326673-p8qbxi57 162 42 the the DT cord-326673-p8qbxi57 162 43 detection detection NN cord-326673-p8qbxi57 162 44 of of IN cord-326673-p8qbxi57 162 45 antibodies antibody NNS cord-326673-p8qbxi57 162 46 against against IN cord-326673-p8qbxi57 162 47 foot foot NN cord-326673-p8qbxi57 162 48 - - HYPH cord-326673-p8qbxi57 162 49 and and CC cord-326673-p8qbxi57 162 50 - - HYPH cord-326673-p8qbxi57 162 51 month month NN cord-326673-p8qbxi57 162 52 disease disease NN cord-326673-p8qbxi57 162 53 virus virus NN cord-326673-p8qbxi57 162 54 . . . cord-326673-p8qbxi57 163 1 III III NNP cord-326673-p8qbxi57 163 2 . . . cord-326673-p8qbxi57 164 1 Evaluation evaluation NN cord-326673-p8qbxi57 164 2 of of IN cord-326673-p8qbxi57 164 3 antibodies antibody NNS cord-326673-p8qbxi57 164 4 after after IN cord-326673-p8qbxi57 164 5 infection infection NN cord-326673-p8qbxi57 164 6 . . . cord-326673-p8qbxi57 165 1 Epidemiolo~ epidemiolo~ UH cord-326673-p8qbxi57 165 2 , , , cord-326673-p8qbxi57 165 3 a a DT cord-326673-p8qbxi57 165 4 ~ ~ NFP cord-326673-p8qbxi57 165 5 Td Td NNP cord-326673-p8qbxi57 165 6 h h NN cord-326673-p8qbxi57 165 7 ~ ~ NFP cord-326673-p8qbxi57 165 8 fection fection NN cord-326673-p8qbxi57 165 9 99 99 CD cord-326673-p8qbxi57 165 10 Failure failure NN cord-326673-p8qbxi57 165 11 of of IN cord-326673-p8qbxi57 165 12 malaria malaria NN cord-326673-p8qbxi57 165 13 vaccination vaccination NN cord-326673-p8qbxi57 165 14 in in IN cord-326673-p8qbxi57 165 15 mice mouse NNS cord-326673-p8qbxi57 165 16 born bear VBN cord-326673-p8qbxi57 165 17 to to IN cord-326673-p8qbxi57 165 18 immtme immtme NNP cord-326673-p8qbxi57 165 19 mothers mother NNS cord-326673-p8qbxi57 165 20 . . . cord-326673-p8qbxi57 166 1 II II NNP cord-326673-p8qbxi57 166 2 . . . cord-326673-p8qbxi57 167 1 Induction induction NN cord-326673-p8qbxi57 167 2 of of IN cord-326673-p8qbxi57 167 3 specific specific JJ cord-326673-p8qbxi57 167 4 suppressor suppressor NN cord-326673-p8qbxi57 167 5 cells cell NNS cord-326673-p8qbxi57 167 6 by by IN cord-326673-p8qbxi57 167 7 maternal maternal JJ cord-326673-p8qbxi57 167 8 IgG igg NN cord-326673-p8qbxi57 167 9 Mucosal Mucosal NNP cord-326673-p8qbxi57 167 10 and and CC cord-326673-p8qbxi57 167 11 systemic systemic JJ cord-326673-p8qbxi57 167 12 antibody antibody NN cord-326673-p8qbxi57 167 13 responses response NNS cord-326673-p8qbxi57 167 14 to to IN cord-326673-p8qbxi57 167 15 bovine bovine JJ cord-326673-p8qbxi57 167 16 coronavirus coronavirus NN cord-326673-p8qbxi57 167 17 structural structural JJ cord-326673-p8qbxi57 167 18 proteins protein NNS cord-326673-p8qbxi57 167 19 in in IN cord-326673-p8qbxi57 167 20 experimentally experimentally RB cord-326673-p8qbxi57 167 21 challengeexposed challengeexpose VBN cord-326673-p8qbxi57 167 22 calves calf NNS cord-326673-p8qbxi57 167 23 fed feed VBD cord-326673-p8qbxi57 167 24 low low JJ cord-326673-p8qbxi57 167 25 or or CC cord-326673-p8qbxi57 167 26 high high JJ cord-326673-p8qbxi57 167 27 amonnts amonnt NNS cord-326673-p8qbxi57 167 28 of of IN cord-326673-p8qbxi57 167 29 colostral colostral JJ cord-326673-p8qbxi57 167 30 antibodies antibody NNS cord-326673-p8qbxi57 167 31 Antibody Antibody NNP cord-326673-p8qbxi57 167 32 response response NN cord-326673-p8qbxi57 167 33 to to IN cord-326673-p8qbxi57 167 34 neonatal neonatal JJ cord-326673-p8qbxi57 167 35 vaccination vaccination NN cord-326673-p8qbxi57 167 36 in in IN cord-326673-p8qbxi57 167 37 calves calf NNS cord-326673-p8qbxi57 167 38 Towards towards IN cord-326673-p8qbxi57 167 39 a a DT cord-326673-p8qbxi57 167 40 nenvork nenvork NN cord-326673-p8qbxi57 167 41 theory theory NN cord-326673-p8qbxi57 167 42 of of IN cord-326673-p8qbxi57 167 43 the the DT cord-326673-p8qbxi57 167 44 immune immune JJ cord-326673-p8qbxi57 167 45 system system NN cord-326673-p8qbxi57 167 46 Adaptive adaptive JJ cord-326673-p8qbxi57 167 47 differentiation differentiation NN cord-326673-p8qbxi57 167 48 of of IN cord-326673-p8qbxi57 167 49 lymphocytes lymphocyte NNS cord-326673-p8qbxi57 167 50 : : : cord-326673-p8qbxi57 168 1 Theoretical theoretical JJ cord-326673-p8qbxi57 168 2 implications implication NNS cord-326673-p8qbxi57 168 3 for for IN cord-326673-p8qbxi57 168 4 mechanisms mechanism NNS cord-326673-p8qbxi57 168 5 of of IN cord-326673-p8qbxi57 168 6 cell cell NN cord-326673-p8qbxi57 168 7 - - HYPH cord-326673-p8qbxi57 168 8 cell cell NN cord-326673-p8qbxi57 168 9 recognition recognition NN cord-326673-p8qbxi57 168 10 and and CC cord-326673-p8qbxi57 168 11 regulation regulation NN cord-326673-p8qbxi57 168 12 of of IN cord-326673-p8qbxi57 168 13 imnmne imnmne NN cord-326673-p8qbxi57 168 14 responses response NNS cord-326673-p8qbxi57 168 15 Printing print VBG cord-326673-p8qbxi57 168 16 for for IN cord-326673-p8qbxi57 168 17 local local JJ cord-326673-p8qbxi57 168 18 and and CC cord-326673-p8qbxi57 168 19 systemic systemic JJ cord-326673-p8qbxi57 168 20 antibody antibody NN cord-326673-p8qbxi57 168 21 memory memory NN cord-326673-p8qbxi57 168 22 responses response NNS cord-326673-p8qbxi57 168 23 to to IN cord-326673-p8qbxi57 168 24 bovine bovine JJ cord-326673-p8qbxi57 168 25 respirato respirato NNP cord-326673-p8qbxi57 168 26 W W NNP cord-326673-p8qbxi57 168 27 syncitial syncitial NN cord-326673-p8qbxi57 168 28 virus virus NN cord-326673-p8qbxi57 168 29 : : : cord-326673-p8qbxi57 168 30 effect effect NN cord-326673-p8qbxi57 168 31 of of IN cord-326673-p8qbxi57 168 32 amotmt amotmt NN cord-326673-p8qbxi57 168 33 of of IN cord-326673-p8qbxi57 168 34 virus virus NN cord-326673-p8qbxi57 168 35 , , , cord-326673-p8qbxi57 168 36 virus virus NN cord-326673-p8qbxi57 168 37 replication replication NN cord-326673-p8qbxi57 168 38 , , , cord-326673-p8qbxi57 168 39 route route NN cord-326673-p8qbxi57 168 40 of of IN cord-326673-p8qbxi57 168 41 administration administration NN cord-326673-p8qbxi57 168 42 and and CC cord-326673-p8qbxi57 168 43 maternal maternal JJ cord-326673-p8qbxi57 168 44 antibodies antibody NNS cord-326673-p8qbxi57 168 45 Circumvention circumvention NN cord-326673-p8qbxi57 168 46 of of IN cord-326673-p8qbxi57 168 47 maternal maternal JJ cord-326673-p8qbxi57 168 48 antibody antibody NN cord-326673-p8qbxi57 168 49 of of IN cord-326673-p8qbxi57 168 50 newborn newborn JJ cord-326673-p8qbxi57 168 51 pigs pig NNS cord-326673-p8qbxi57 168 52 with with IN cord-326673-p8qbxi57 168 53 glycoprotein glycoprotein NN cord-326673-p8qbxi57 168 54 gIII giii CD cord-326673-p8qbxi57 168 55 - - HYPH cord-326673-p8qbxi57 168 56 deleted delete VBN cord-326673-p8qbxi57 168 57 marker marker NN cord-326673-p8qbxi57 168 58 vaccine vaccine NN cord-326673-p8qbxi57 168 59 Tile Tile NNP cord-326673-p8qbxi57 168 60 application application NN cord-326673-p8qbxi57 168 61 of of IN cord-326673-p8qbxi57 168 62 biotechnology biotechnology NN cord-326673-p8qbxi57 168 63 to to IN cord-326673-p8qbxi57 168 64 the the DT cord-326673-p8qbxi57 168 65 conu conu NN cord-326673-p8qbxi57 168 66 - - HYPH cord-326673-p8qbxi57 168 67 ol ol NN cord-326673-p8qbxi57 168 68 of of IN cord-326673-p8qbxi57 168 69 foot foot NN cord-326673-p8qbxi57 168 70 - - HYPH cord-326673-p8qbxi57 168 71 and and CC cord-326673-p8qbxi57 168 72 - - HYPH cord-326673-p8qbxi57 168 73 mouth mouth NN cord-326673-p8qbxi57 168 74 disease disease NN cord-326673-p8qbxi57 168 75 virus virus NN cord-326673-p8qbxi57 168 76 Maternal maternal JJ cord-326673-p8qbxi57 168 77 antigenic antigenic JJ cord-326673-p8qbxi57 168 78 stimulation stimulation NN cord-326673-p8qbxi57 168 79 actively actively RB cord-326673-p8qbxi57 168 80 produces produce VBZ cord-326673-p8qbxi57 168 81 suppressor suppressor NN cord-326673-p8qbxi57 168 82 activity activity NN cord-326673-p8qbxi57 168 83 in in IN cord-326673-p8qbxi57 168 84 offspring offspre VBG cord-326673-p8qbxi57 168 85 Sensitisation Sensitisation NNP cord-326673-p8qbxi57 168 86 studies study NNS cord-326673-p8qbxi57 168 87 with with IN cord-326673-p8qbxi57 168 88 the the DT cord-326673-p8qbxi57 168 89 intranasal intranasal NN cord-326673-p8qbxi57 168 90 ( ( -LRB- cord-326673-p8qbxi57 168 91 I.N. I.N. NNP cord-326673-p8qbxi57 168 92 ) ) -RRB- cord-326673-p8qbxi57 168 93 vaccine vaccine NN cord-326673-p8qbxi57 168 94 ( ( -LRB- cord-326673-p8qbxi57 168 95 S S NNP cord-326673-p8qbxi57 168 96 ~ ~ CD cord-326673-p8qbxi57 168 97 vax3,n vax3,n NN cord-326673-p8qbxi57 168 98 ) ) -RRB- cord-326673-p8qbxi57 168 99 against against IN cord-326673-p8qbxi57 168 100 Aujeszky Aujeszky NNP cord-326673-p8qbxi57 168 101 's 's POS cord-326673-p8qbxi57 168 102 disease disease NN cord-326673-p8qbxi57 168 103 based base VBN cord-326673-p8qbxi57 168 104 on on IN cord-326673-p8qbxi57 168 105 the the DT cord-326673-p8qbxi57 168 106 Bartha Bartha NNP cord-326673-p8qbxi57 168 107 strain strain VB cord-326673-p8qbxi57 168 108 Vaccination vaccination NN cord-326673-p8qbxi57 168 109 with with IN cord-326673-p8qbxi57 168 110 inamunodonfinant inamunodonfinant NN cord-326673-p8qbxi57 168 111 peptides peptide NNS cord-326673-p8qbxi57 168 112 encapsulated encapsulate VBN cord-326673-p8qbxi57 168 113 in in IN cord-326673-p8qbxi57 168 114 Quil Quil NNP cord-326673-p8qbxi57 168 115 A A NNP cord-326673-p8qbxi57 168 116 - - HYPH cord-326673-p8qbxi57 168 117 containing containing NN cord-326673-p8qbxi57 168 118 liposomes liposome NNS cord-326673-p8qbxi57 168 119 induces induce VBZ cord-326673-p8qbxi57 168 120 peptide peptide NN cord-326673-p8qbxi57 168 121 - - HYPH cord-326673-p8qbxi57 168 122 specific specific JJ cord-326673-p8qbxi57 168 123 primary primary JJ cord-326673-p8qbxi57 168 124 CD8 CD8 NNP cord-326673-p8qbxi57 168 125 + + CC cord-326673-p8qbxi57 168 126 cytotoxic cytotoxic JJ cord-326673-p8qbxi57 168 127 T t NN cord-326673-p8qbxi57 168 128 cells cell NNS cord-326673-p8qbxi57 168 129 Changes change NNS cord-326673-p8qbxi57 168 130 in in IN cord-326673-p8qbxi57 168 131 the the DT cord-326673-p8qbxi57 168 132 serum serum NN cord-326673-p8qbxi57 168 133 immtmoglobulin immtmoglobulin NN cord-326673-p8qbxi57 168 134 levels level NNS cord-326673-p8qbxi57 168 135 of of IN cord-326673-p8qbxi57 168 136 colostrum colostrum NN cord-326673-p8qbxi57 168 137 - - HYPH cord-326673-p8qbxi57 168 138 fed feed VBN cord-326673-p8qbxi57 168 139 calves calf NNS cord-326673-p8qbxi57 168 140 during during IN cord-326673-p8qbxi57 168 141 the the DT cord-326673-p8qbxi57 168 142 first first JJ cord-326673-p8qbxi57 168 143 12 12 CD cord-326673-p8qbxi57 168 144 weeks week NNS cord-326673-p8qbxi57 168 145 post post JJ cord-326673-p8qbxi57 168 146 - - JJ cord-326673-p8qbxi57 168 147 partum partum JJ cord-326673-p8qbxi57 168 148 Anti anti JJ cord-326673-p8qbxi57 168 149 - - JJ cord-326673-p8qbxi57 168 150 xdral xdral JJ cord-326673-p8qbxi57 168 151 responses response NNS cord-326673-p8qbxi57 168 152 of of IN cord-326673-p8qbxi57 168 153 bluetongue bluetongue NN cord-326673-p8qbxi57 168 154 virus virus NN cord-326673-p8qbxi57 168 155 - - HYPH cord-326673-p8qbxi57 168 156 inoculated inoculate VBN cord-326673-p8qbxi57 168 157 bovine bovine JJ cord-326673-p8qbxi57 168 158 foetuses foetus NNS cord-326673-p8qbxi57 168 159 and and CC cord-326673-p8qbxi57 168 160 their -PRON- PRP$ cord-326673-p8qbxi57 168 161 dams dam NNS cord-326673-p8qbxi57 168 162 Clinical clinical JJ cord-326673-p8qbxi57 168 163 and and CC cord-326673-p8qbxi57 168 164 immunologic immunologic JJ cord-326673-p8qbxi57 168 165 responses response NNS cord-326673-p8qbxi57 168 166 of of IN cord-326673-p8qbxi57 168 167 calves calf NNS cord-326673-p8qbxi57 168 168 with with IN cord-326673-p8qbxi57 168 169 colostrally colostrally RB cord-326673-p8qbxi57 168 170 acquired acquire VBN cord-326673-p8qbxi57 168 171 maternal maternal JJ cord-326673-p8qbxi57 168 172 antibody antibody NN cord-326673-p8qbxi57 168 173 against against IN cord-326673-p8qbxi57 168 174 parainfluenza-3 parainfluenza-3 NNP cord-326673-p8qbxi57 168 175 virus virus NN cord-326673-p8qbxi57 168 176 to to IN cord-326673-p8qbxi57 168 177 homologous homologous JJ cord-326673-p8qbxi57 168 178 viral viral JJ cord-326673-p8qbxi57 168 179 infection infection NN cord-326673-p8qbxi57 168 180 hnmune hnmune JJ cord-326673-p8qbxi57 168 181 response response NN cord-326673-p8qbxi57 168 182 of of IN cord-326673-p8qbxi57 168 183 neonatal neonatal JJ cord-326673-p8qbxi57 168 184 swine swine NN cord-326673-p8qbxi57 168 185 to to IN cord-326673-p8qbxi57 168 186 inactivated inactivate VBN cord-326673-p8qbxi57 168 187 FMDV FMDV NNP cord-326673-p8qbxi57 168 188 vaccine vaccine NN cord-326673-p8qbxi57 168 189 with with IN cord-326673-p8qbxi57 168 190 oil oil NN cord-326673-p8qbxi57 168 191 adjuvant adjuvant NN cord-326673-p8qbxi57 168 192 . . . cord-326673-p8qbxi57 169 1 I. I. NNP cord-326673-p8qbxi57 169 2 Influence influence NN cord-326673-p8qbxi57 169 3 of of IN cord-326673-p8qbxi57 169 4 colostral colostral JJ cord-326673-p8qbxi57 169 5 antibody antibody NN cord-326673-p8qbxi57 170 1 The the DT cord-326673-p8qbxi57 170 2 effect effect NN cord-326673-p8qbxi57 170 3 of of IN cord-326673-p8qbxi57 170 4 maternally maternally RB cord-326673-p8qbxi57 170 5 derived derive VBN cord-326673-p8qbxi57 170 6 antibodies antibody NNS cord-326673-p8qbxi57 170 7 on on IN cord-326673-p8qbxi57 170 8 the the DT cord-326673-p8qbxi57 170 9 response response NN cord-326673-p8qbxi57 170 10 of of IN cord-326673-p8qbxi57 170 11 calves calf NNS cord-326673-p8qbxi57 170 12 to to IN cord-326673-p8qbxi57 170 13 vaccination vaccination NN cord-326673-p8qbxi57 170 14 against against IN cord-326673-p8qbxi57 170 15 foot foot NN cord-326673-p8qbxi57 170 16 - - HYPH cord-326673-p8qbxi57 170 17 and and CC cord-326673-p8qbxi57 170 18 - - HYPH cord-326673-p8qbxi57 170 19 mouth mouth NN cord-326673-p8qbxi57 170 20 disease disease NN cord-326673-p8qbxi57 170 21 Effect effect NN cord-326673-p8qbxi57 170 22 of of IN cord-326673-p8qbxi57 170 23 age age NN cord-326673-p8qbxi57 170 24 on on IN cord-326673-p8qbxi57 170 25 response response NN cord-326673-p8qbxi57 170 26 of of IN cord-326673-p8qbxi57 170 27 cattle cattle NNS cord-326673-p8qbxi57 170 28 to to IN cord-326673-p8qbxi57 170 29 vaccination vaccination NN cord-326673-p8qbxi57 170 30 against against IN cord-326673-p8qbxi57 170 31 foot foot NN cord-326673-p8qbxi57 170 32 - - HYPH cord-326673-p8qbxi57 170 33 and and CC cord-326673-p8qbxi57 170 34 - - HYPH cord-326673-p8qbxi57 170 35 mouth mouth NN cord-326673-p8qbxi57 170 36 disease disease NN cord-326673-p8qbxi57 170 37 Ontogeny ontogeny NN cord-326673-p8qbxi57 170 38 of of IN cord-326673-p8qbxi57 170 39 inmaune inmaune JJ cord-326673-p8qbxi57 170 40 responses response NNS cord-326673-p8qbxi57 170 41 in in IN cord-326673-p8qbxi57 170 42 cattle cattle NNS cord-326673-p8qbxi57 170 43 Colostral Colostral NNP cord-326673-p8qbxi57 170 44 cell cell NN cord-326673-p8qbxi57 170 45 - - HYPH cord-326673-p8qbxi57 170 46 mediated mediate VBN cord-326673-p8qbxi57 170 47 immulfity immulfity NN cord-326673-p8qbxi57 170 48 and and CC cord-326673-p8qbxi57 170 49 the the DT cord-326673-p8qbxi57 170 50 concept concept NN cord-326673-p8qbxi57 170 51 of of IN cord-326673-p8qbxi57 170 52 a a DT cord-326673-p8qbxi57 170 53 common common JJ cord-326673-p8qbxi57 170 54 secretol secretol NNP cord-326673-p8qbxi57 170 55 - - HYPH cord-326673-p8qbxi57 170 56 y y NNP cord-326673-p8qbxi57 170 57 inamune inamune NNP cord-326673-p8qbxi57 170 58 system system NN cord-326673-p8qbxi57 170 59 A a DT cord-326673-p8qbxi57 170 60 recombinant recombinant JJ cord-326673-p8qbxi57 170 61 vaccinia vaccinia NN cord-326673-p8qbxi57 170 62 - - HYPH cord-326673-p8qbxi57 170 63 rabies rabie VBN cord-326673-p8qbxi57 170 64 virus virus NN cord-326673-p8qbxi57 170 65 for for IN cord-326673-p8qbxi57 170 66 oral oral JJ cord-326673-p8qbxi57 170 67 vaccination vaccination NN cord-326673-p8qbxi57 170 68 of of IN cord-326673-p8qbxi57 170 69 wildlife wildlife NN cord-326673-p8qbxi57 170 70 against against IN cord-326673-p8qbxi57 170 71 rabies rabie VBN cord-326673-p8qbxi57 170 72 Single single JJ cord-326673-p8qbxi57 170 73 capripoxvirus capripoxvirus NN cord-326673-p8qbxi57 170 74 recombinant recombinant JJ cord-326673-p8qbxi57 170 75 vaccine vaccine NN cord-326673-p8qbxi57 170 76 for for IN cord-326673-p8qbxi57 170 77 the the DT cord-326673-p8qbxi57 170 78 protection protection NN cord-326673-p8qbxi57 170 79 of of IN cord-326673-p8qbxi57 170 80 cattle cattle NNS cord-326673-p8qbxi57 170 81 against against IN cord-326673-p8qbxi57 170 82 rinderpest rinderpest NN cord-326673-p8qbxi57 170 83 and and CC cord-326673-p8qbxi57 170 84 lumpy lumpy JJ cord-326673-p8qbxi57 170 85 skin skin NN cord-326673-p8qbxi57 170 86 disease disease NN cord-326673-p8qbxi57 170 87 Response response NN cord-326673-p8qbxi57 170 88 to to IN cord-326673-p8qbxi57 170 89 foot foot NN cord-326673-p8qbxi57 170 90 - - HYPH cord-326673-p8qbxi57 170 91 and and CC cord-326673-p8qbxi57 170 92 - - HYPH cord-326673-p8qbxi57 170 93 mouth mouth NN cord-326673-p8qbxi57 170 94 disease disease NN cord-326673-p8qbxi57 170 95 vaccines vaccine NNS cord-326673-p8qbxi57 170 96 in in IN cord-326673-p8qbxi57 170 97 newborn newborn JJ cord-326673-p8qbxi57 170 98 calves calf NNS cord-326673-p8qbxi57 170 99 . . . cord-326673-p8qbxi57 171 1 Influence influence NN cord-326673-p8qbxi57 171 2 of of IN cord-326673-p8qbxi57 171 3 age age NN cord-326673-p8qbxi57 171 4 , , , cord-326673-p8qbxi57 171 5 colostral colostral JJ cord-326673-p8qbxi57 171 6 antibodies antibody NNS cord-326673-p8qbxi57 171 7 and and CC cord-326673-p8qbxi57 171 8 adjuvants adjuvant NNS cord-326673-p8qbxi57 172 1 Bovine Bovine NNP cord-326673-p8qbxi57 172 2 parainfluenza-3 parainfluenza-3 NNP cord-326673-p8qbxi57 172 3 vaccine vaccine NN cord-326673-p8qbxi57 172 4 studies study NNS cord-326673-p8qbxi57 172 5 Regulatory regulatory JJ cord-326673-p8qbxi57 172 6 effect effect NN cord-326673-p8qbxi57 172 7 of of IN cord-326673-p8qbxi57 172 8 antibody antibody NN cord-326673-p8qbxi57 172 9 on on IN cord-326673-p8qbxi57 172 10 the the DT cord-326673-p8qbxi57 172 11 intmtme intmtme JJ cord-326673-p8qbxi57 172 12 response response NN cord-326673-p8qbxi57 172 13 Interference Interference NNP cord-326673-p8qbxi57 172 14 of of IN cord-326673-p8qbxi57 172 15 maternal maternal JJ cord-326673-p8qbxi57 172 16 antibodies antibody NNS cord-326673-p8qbxi57 172 17 with with IN cord-326673-p8qbxi57 172 18 the the DT cord-326673-p8qbxi57 172 19 immnne immnne NNP cord-326673-p8qbxi57 172 20 response response NN cord-326673-p8qbxi57 172 21 of of IN cord-326673-p8qbxi57 172 22 foals foal NNS cord-326673-p8qbxi57 172 23 after after IN cord-326673-p8qbxi57 172 24 vaccination vaccination NN cord-326673-p8qbxi57 172 25 against against IN cord-326673-p8qbxi57 172 26 equine equine JJ cord-326673-p8qbxi57 172 27 influenza influenza NN cord-326673-p8qbxi57 172 28 Intranasal Intranasal NNP cord-326673-p8qbxi57 172 29 vaccination vaccination NN cord-326673-p8qbxi57 172 30 of of IN cord-326673-p8qbxi57 172 31 pigs pig NNS cord-326673-p8qbxi57 172 32 against against IN cord-326673-p8qbxi57 172 33 Aujeszky Aujeszky NNP cord-326673-p8qbxi57 172 34 's 's POS cord-326673-p8qbxi57 172 35 disease disease NN cord-326673-p8qbxi57 172 36 . . . cord-326673-p8qbxi57 173 1 Comparison comparison NN cord-326673-p8qbxi57 173 2 with with IN cord-326673-p8qbxi57 173 3 one one CD cord-326673-p8qbxi57 173 4 or or CC cord-326673-p8qbxi57 173 5 two two CD cord-326673-p8qbxi57 173 6 doses dose NNS cord-326673-p8qbxi57 173 7 of of IN cord-326673-p8qbxi57 173 8 an an DT cord-326673-p8qbxi57 173 9 inactivated inactivated JJ cord-326673-p8qbxi57 173 10 vaccine vaccine NN cord-326673-p8qbxi57 173 11 in in IN cord-326673-p8qbxi57 173 12 pigs pig NNS cord-326673-p8qbxi57 173 13 with with IN cord-326673-p8qbxi57 173 14 moderate moderate JJ cord-326673-p8qbxi57 173 15 maternal maternal JJ cord-326673-p8qbxi57 173 16 antibody antibody NN cord-326673-p8qbxi57 173 17 titres titre NNS cord-326673-p8qbxi57 173 18 Aujeszky Aujeszky NNP cord-326673-p8qbxi57 173 19 's 's POS cord-326673-p8qbxi57 173 20 disease disease NN cord-326673-p8qbxi57 173 21 vaccination vaccination NN cord-326673-p8qbxi57 173 22 and and CC cord-326673-p8qbxi57 173 23 infection infection NN cord-326673-p8qbxi57 173 24 of of IN cord-326673-p8qbxi57 173 25 pigs pig NNS cord-326673-p8qbxi57 173 26 with with IN cord-326673-p8qbxi57 173 27 maternal maternal JJ cord-326673-p8qbxi57 173 28 immunity immunity NN cord-326673-p8qbxi57 173 29 : : : cord-326673-p8qbxi57 173 30 effects effect NNS cord-326673-p8qbxi57 173 31 on on IN cord-326673-p8qbxi57 173 32 cell cell NN cord-326673-p8qbxi57 173 33 - - HYPH cord-326673-p8qbxi57 173 34 and and CC cord-326673-p8qbxi57 173 35 antibody antibody NN cord-326673-p8qbxi57 173 36 - - HYPH cord-326673-p8qbxi57 173 37 mediated mediate VBN cord-326673-p8qbxi57 173 38 immunity immunity NN cord-326673-p8qbxi57 173 39 Transfer transfer NN cord-326673-p8qbxi57 173 40 of of IN cord-326673-p8qbxi57 173 41 maternal maternal JJ cord-326673-p8qbxi57 173 42 antibodies antibody NNS cord-326673-p8qbxi57 173 43 results result NNS cord-326673-p8qbxi57 173 44 in in IN cord-326673-p8qbxi57 173 45 inhibition inhibition NN cord-326673-p8qbxi57 173 46 of of IN cord-326673-p8qbxi57 173 47 specific specific JJ cord-326673-p8qbxi57 173 48 immune immune JJ cord-326673-p8qbxi57 173 49 responses response NNS cord-326673-p8qbxi57 173 50 in in IN cord-326673-p8qbxi57 173 51 the the DT cord-326673-p8qbxi57 173 52 offspring offspring NN cord-326673-p8qbxi57 173 53 Protection Protection NNP cord-326673-p8qbxi57 173 54 of of IN cord-326673-p8qbxi57 173 55 cattle cattle NNS cord-326673-p8qbxi57 173 56 against against IN cord-326673-p8qbxi57 173 57 rinderpest rinderpest NN cord-326673-p8qbxi57 173 58 with with IN cord-326673-p8qbxi57 173 59 infectious infectious JJ cord-326673-p8qbxi57 173 60 vaccine vaccine NN cord-326673-p8qbxi57 173 61 virus virus NN cord-326673-p8qbxi57 173 62 recombinant recombinant JJ cord-326673-p8qbxi57 173 63 expressing express VBG cord-326673-p8qbxi57 173 64 the the DT cord-326673-p8qbxi57 173 65 HA HA NNP cord-326673-p8qbxi57 173 66 or or CC cord-326673-p8qbxi57 173 67 F F NNP cord-326673-p8qbxi57 173 68 gene gene NN