id sid tid token lemma pos cord-328753-qwdxgk4z 1 1 key key JJ cord-328753-qwdxgk4z 2 1 : : : cord-328753-qwdxgk4z 2 2 cord-328753-qwdxgk4z cord-328753-qwdxgk4z NN cord-328753-qwdxgk4z 2 3 authors author NNS cord-328753-qwdxgk4z 2 4 : : : cord-328753-qwdxgk4z 2 5 Lafaye Lafaye NNP cord-328753-qwdxgk4z 2 6 , , , cord-328753-qwdxgk4z 2 7 Pierre Pierre NNP cord-328753-qwdxgk4z 2 8 ; ; : cord-328753-qwdxgk4z 2 9 Li Li NNP cord-328753-qwdxgk4z 2 10 , , , cord-328753-qwdxgk4z 2 11 Tengfei Tengfei NNP cord-328753-qwdxgk4z 2 12 title title NN cord-328753-qwdxgk4z 2 13 : : : cord-328753-qwdxgk4z 2 14 Use Use NNP cord-328753-qwdxgk4z 2 15 of of IN cord-328753-qwdxgk4z 2 16 camel camel NN cord-328753-qwdxgk4z 2 17 single single JJ cord-328753-qwdxgk4z 2 18 - - HYPH cord-328753-qwdxgk4z 2 19 domain domain NN cord-328753-qwdxgk4z 2 20 antibodies antibody NNS cord-328753-qwdxgk4z 2 21 for for IN cord-328753-qwdxgk4z 2 22 the the DT cord-328753-qwdxgk4z 2 23 diagnosis diagnosis NN cord-328753-qwdxgk4z 2 24 and and CC cord-328753-qwdxgk4z 2 25 treatment treatment NN cord-328753-qwdxgk4z 2 26 of of IN cord-328753-qwdxgk4z 2 27 zoonotic zoonotic JJ cord-328753-qwdxgk4z 2 28 diseases disease NNS cord-328753-qwdxgk4z 2 29 date date NN cord-328753-qwdxgk4z 2 30 : : : cord-328753-qwdxgk4z 2 31 2018 2018 CD cord-328753-qwdxgk4z 2 32 - - HYPH cord-328753-qwdxgk4z 2 33 09 09 CD cord-328753-qwdxgk4z 2 34 - - SYM cord-328753-qwdxgk4z 2 35 25 25 CD cord-328753-qwdxgk4z 2 36 journal journal NN cord-328753-qwdxgk4z 2 37 : : : cord-328753-qwdxgk4z 3 1 Comp Comp NNP cord-328753-qwdxgk4z 3 2 Immunol Immunol NNP cord-328753-qwdxgk4z 3 3 Microbiol Microbiol NNP cord-328753-qwdxgk4z 4 1 Infect infect VB cord-328753-qwdxgk4z 4 2 Dis Dis NNP cord-328753-qwdxgk4z 4 3 DOI doi NN cord-328753-qwdxgk4z 5 1 : : : cord-328753-qwdxgk4z 5 2 10.1016 10.1016 CD cord-328753-qwdxgk4z 5 3 / / SYM cord-328753-qwdxgk4z 5 4 j.cimid.2018.09.009 j.cimid.2018.09.009 NNP cord-328753-qwdxgk4z 5 5 sha sha NNP cord-328753-qwdxgk4z 5 6 : : : cord-328753-qwdxgk4z 5 7 9106288bcdc9e21572ae3ed51e7dfb7c24739b2b 9106288bcdc9e21572ae3ed51e7dfb7c24739b2b CD cord-328753-qwdxgk4z 5 8 doc_id doc_id CD cord-328753-qwdxgk4z 5 9 : : : cord-328753-qwdxgk4z 5 10 328753 328753 CD cord-328753-qwdxgk4z 5 11 cord_uid cord_uid NNS cord-328753-qwdxgk4z 5 12 : : : cord-328753-qwdxgk4z 6 1 qwdxgk4z qwdxgk4z NNP cord-328753-qwdxgk4z 7 1 Camelids camelid NNS cord-328753-qwdxgk4z 7 2 produce produce VBP cord-328753-qwdxgk4z 7 3 both both DT cord-328753-qwdxgk4z 7 4 conventional conventional JJ cord-328753-qwdxgk4z 7 5 heterotetrameric heterotetrameric JJ cord-328753-qwdxgk4z 7 6 antibodies antibody NNS cord-328753-qwdxgk4z 7 7 and and CC cord-328753-qwdxgk4z 7 8 homodimeric homodimeric NNP cord-328753-qwdxgk4z 7 9 heavy heavy JJ cord-328753-qwdxgk4z 7 10 - - HYPH cord-328753-qwdxgk4z 7 11 chain chain NN cord-328753-qwdxgk4z 7 12 only only RB cord-328753-qwdxgk4z 7 13 antibodies antibody NNS cord-328753-qwdxgk4z 7 14 . . . cord-328753-qwdxgk4z 8 1 The the DT cord-328753-qwdxgk4z 8 2 antigen antigen NN cord-328753-qwdxgk4z 8 3 - - HYPH cord-328753-qwdxgk4z 8 4 binding bind VBG cord-328753-qwdxgk4z 8 5 region region NN cord-328753-qwdxgk4z 8 6 of of IN cord-328753-qwdxgk4z 8 7 such such JJ cord-328753-qwdxgk4z 8 8 homodimeric homodimeric NNP cord-328753-qwdxgk4z 8 9 heavy heavy JJ cord-328753-qwdxgk4z 8 10 - - HYPH cord-328753-qwdxgk4z 8 11 chain chain NN cord-328753-qwdxgk4z 8 12 only only RB cord-328753-qwdxgk4z 8 13 antibodies antibody NNS cord-328753-qwdxgk4z 8 14 consists consist VBZ cord-328753-qwdxgk4z 8 15 of of IN cord-328753-qwdxgk4z 8 16 one one CD cord-328753-qwdxgk4z 8 17 single single JJ cord-328753-qwdxgk4z 8 18 domain domain NN cord-328753-qwdxgk4z 8 19 , , , cord-328753-qwdxgk4z 8 20 called call VBN cord-328753-qwdxgk4z 8 21 VHH VHH NNP cord-328753-qwdxgk4z 8 22 . . . cord-328753-qwdxgk4z 9 1 VHHs vhh NNS cord-328753-qwdxgk4z 9 2 provide provide VBP cord-328753-qwdxgk4z 9 3 many many JJ cord-328753-qwdxgk4z 9 4 advantages advantage NNS cord-328753-qwdxgk4z 9 5 over over IN cord-328753-qwdxgk4z 9 6 conventional conventional JJ cord-328753-qwdxgk4z 9 7 full full JJ cord-328753-qwdxgk4z 9 8 - - HYPH cord-328753-qwdxgk4z 9 9 sized sized JJ cord-328753-qwdxgk4z 9 10 antibodies antibody NNS cord-328753-qwdxgk4z 9 11 and and CC cord-328753-qwdxgk4z 9 12 currently currently RB cord-328753-qwdxgk4z 9 13 used use VBN cord-328753-qwdxgk4z 9 14 antibody antibody NN cord-328753-qwdxgk4z 9 15 - - HYPH cord-328753-qwdxgk4z 9 16 based base VBN cord-328753-qwdxgk4z 9 17 fragments fragment NNS cord-328753-qwdxgk4z 9 18 ( ( -LRB- cord-328753-qwdxgk4z 9 19 Fab Fab NNP cord-328753-qwdxgk4z 9 20 , , , cord-328753-qwdxgk4z 9 21 scFv scFv NNP cord-328753-qwdxgk4z 9 22 ) ) -RRB- cord-328753-qwdxgk4z 9 23 , , , cord-328753-qwdxgk4z 9 24 including include VBG cord-328753-qwdxgk4z 9 25 high high JJ cord-328753-qwdxgk4z 9 26 specificity specificity NN cord-328753-qwdxgk4z 9 27 , , , cord-328753-qwdxgk4z 9 28 stability stability NN cord-328753-qwdxgk4z 9 29 and and CC cord-328753-qwdxgk4z 9 30 solubility solubility NN cord-328753-qwdxgk4z 9 31 , , , cord-328753-qwdxgk4z 9 32 and and CC cord-328753-qwdxgk4z 9 33 small small JJ cord-328753-qwdxgk4z 9 34 size size NN cord-328753-qwdxgk4z 9 35 , , , cord-328753-qwdxgk4z 9 36 allowing allow VBG cord-328753-qwdxgk4z 9 37 them -PRON- PRP cord-328753-qwdxgk4z 9 38 to to TO cord-328753-qwdxgk4z 9 39 recognize recognize VB cord-328753-qwdxgk4z 9 40 unusual unusual JJ cord-328753-qwdxgk4z 9 41 antigenic antigenic JJ cord-328753-qwdxgk4z 9 42 sites site NNS cord-328753-qwdxgk4z 9 43 and and CC cord-328753-qwdxgk4z 9 44 deeply deeply RB cord-328753-qwdxgk4z 9 45 penetrate penetrate VB cord-328753-qwdxgk4z 9 46 tissues tissue NNS cord-328753-qwdxgk4z 9 47 . . . cord-328753-qwdxgk4z 10 1 Since since IN cord-328753-qwdxgk4z 10 2 their -PRON- PRP$ cord-328753-qwdxgk4z 10 3 discovery discovery NN cord-328753-qwdxgk4z 10 4 , , , cord-328753-qwdxgk4z 10 5 VHHs vhh NNS cord-328753-qwdxgk4z 10 6 have have VBP cord-328753-qwdxgk4z 10 7 been be VBN cord-328753-qwdxgk4z 10 8 used use VBN cord-328753-qwdxgk4z 10 9 extensively extensively RB cord-328753-qwdxgk4z 10 10 in in IN cord-328753-qwdxgk4z 10 11 diagnostics diagnostic NNS cord-328753-qwdxgk4z 10 12 and and CC cord-328753-qwdxgk4z 10 13 therapy therapy NN cord-328753-qwdxgk4z 10 14 . . . cord-328753-qwdxgk4z 11 1 In in IN cord-328753-qwdxgk4z 11 2 recent recent JJ cord-328753-qwdxgk4z 11 3 decades decade NNS cord-328753-qwdxgk4z 11 4 , , , cord-328753-qwdxgk4z 11 5 the the DT cord-328753-qwdxgk4z 11 6 number number NN cord-328753-qwdxgk4z 11 7 of of IN cord-328753-qwdxgk4z 11 8 outbreaks outbreak NNS cord-328753-qwdxgk4z 11 9 of of IN cord-328753-qwdxgk4z 11 10 diseases disease NNS cord-328753-qwdxgk4z 11 11 transmissible transmissible JJ cord-328753-qwdxgk4z 11 12 from from IN cord-328753-qwdxgk4z 11 13 animals animal NNS cord-328753-qwdxgk4z 11 14 to to IN cord-328753-qwdxgk4z 11 15 humans human NNS cord-328753-qwdxgk4z 11 16 has have VBZ cord-328753-qwdxgk4z 11 17 been be VBN cord-328753-qwdxgk4z 11 18 on on IN cord-328753-qwdxgk4z 11 19 the the DT cord-328753-qwdxgk4z 11 20 rise rise NN cord-328753-qwdxgk4z 11 21 . . . cord-328753-qwdxgk4z 12 1 In in IN cord-328753-qwdxgk4z 12 2 this this DT cord-328753-qwdxgk4z 12 3 review review NN cord-328753-qwdxgk4z 12 4 , , , cord-328753-qwdxgk4z 12 5 we -PRON- PRP cord-328753-qwdxgk4z 12 6 evaluate evaluate VBP cord-328753-qwdxgk4z 12 7 the the DT cord-328753-qwdxgk4z 12 8 status status NN cord-328753-qwdxgk4z 12 9 of of IN cord-328753-qwdxgk4z 12 10 VHHs vhh NNS cord-328753-qwdxgk4z 12 11 as as IN cord-328753-qwdxgk4z 12 12 diagnostic diagnostic JJ cord-328753-qwdxgk4z 12 13 and and CC cord-328753-qwdxgk4z 12 14 therapeutic therapeutic JJ cord-328753-qwdxgk4z 12 15 biomolecular biomolecular JJ cord-328753-qwdxgk4z 12 16 agents agent NNS cord-328753-qwdxgk4z 12 17 for for IN cord-328753-qwdxgk4z 12 18 the the DT cord-328753-qwdxgk4z 12 19 detection detection NN cord-328753-qwdxgk4z 12 20 and and CC cord-328753-qwdxgk4z 12 21 treatment treatment NN cord-328753-qwdxgk4z 12 22 of of IN cord-328753-qwdxgk4z 12 23 zoonotic zoonotic JJ cord-328753-qwdxgk4z 12 24 diseases disease NNS cord-328753-qwdxgk4z 12 25 , , , cord-328753-qwdxgk4z 12 26 such such JJ cord-328753-qwdxgk4z 12 27 as as IN cord-328753-qwdxgk4z 12 28 bacterial bacterial JJ cord-328753-qwdxgk4z 12 29 , , , cord-328753-qwdxgk4z 12 30 parasitic parasitic JJ cord-328753-qwdxgk4z 12 31 , , , cord-328753-qwdxgk4z 12 32 and and CC cord-328753-qwdxgk4z 12 33 viral viral JJ cord-328753-qwdxgk4z 12 34 zoonosis zoonosis NN cord-328753-qwdxgk4z 12 35 . . . cord-328753-qwdxgk4z 13 1 VHHs vhh NNS cord-328753-qwdxgk4z 13 2 show show VBP cord-328753-qwdxgk4z 13 3 great great JJ cord-328753-qwdxgk4z 13 4 adaptability adaptability NN cord-328753-qwdxgk4z 13 5 to to TO cord-328753-qwdxgk4z 13 6 inhibit inhibit VB cord-328753-qwdxgk4z 13 7 or or CC cord-328753-qwdxgk4z 13 8 neutralize neutralize VB cord-328753-qwdxgk4z 13 9 pathogenic pathogenic JJ cord-328753-qwdxgk4z 13 10 agents agent NNS cord-328753-qwdxgk4z 13 11 for for IN cord-328753-qwdxgk4z 13 12 the the DT cord-328753-qwdxgk4z 13 13 creation creation NN cord-328753-qwdxgk4z 13 14 of of IN cord-328753-qwdxgk4z 13 15 multifunctional multifunctional JJ cord-328753-qwdxgk4z 13 16 VHH vhh NN cord-328753-qwdxgk4z 13 17 - - HYPH cord-328753-qwdxgk4z 13 18 based base VBN cord-328753-qwdxgk4z 13 19 diagnostic diagnostic JJ cord-328753-qwdxgk4z 13 20 and and CC cord-328753-qwdxgk4z 13 21 therapeutic therapeutic JJ cord-328753-qwdxgk4z 13 22 molecules molecule NNS cord-328753-qwdxgk4z 13 23 against against IN cord-328753-qwdxgk4z 13 24 zoonotic zoonotic JJ cord-328753-qwdxgk4z 13 25 diseases disease NNS cord-328753-qwdxgk4z 13 26 . . . cord-328753-qwdxgk4z 14 1 The the DT cord-328753-qwdxgk4z 14 2 generation generation NN cord-328753-qwdxgk4z 14 3 of of IN cord-328753-qwdxgk4z 14 4 monoclonal monoclonal JJ cord-328753-qwdxgk4z 14 5 antibody antibody NN cord-328753-qwdxgk4z 14 6 ( ( -LRB- cord-328753-qwdxgk4z 14 7 mAb mAb NNS cord-328753-qwdxgk4z 14 8 ) ) -RRB- cord-328753-qwdxgk4z 14 9 triggered trigger VBD cord-328753-qwdxgk4z 14 10 a a DT cord-328753-qwdxgk4z 14 11 revolution revolution NN cord-328753-qwdxgk4z 14 12 in in IN cord-328753-qwdxgk4z 14 13 biotechnology biotechnology NN cord-328753-qwdxgk4z 14 14 . . . cord-328753-qwdxgk4z 15 1 Therapeutic Therapeutic NNP cord-328753-qwdxgk4z 15 2 mAbs mAbs NNP cord-328753-qwdxgk4z 15 3 belong belong VBP cord-328753-qwdxgk4z 15 4 to to IN cord-328753-qwdxgk4z 15 5 the the DT cord-328753-qwdxgk4z 15 6 fastest fast RBS cord-328753-qwdxgk4z 15 7 - - HYPH cord-328753-qwdxgk4z 15 8 growing grow VBG cord-328753-qwdxgk4z 15 9 branch branch NN cord-328753-qwdxgk4z 15 10 of of IN cord-328753-qwdxgk4z 15 11 biotechnology biotechnology NN cord-328753-qwdxgk4z 15 12 . . . cord-328753-qwdxgk4z 16 1 However however RB cord-328753-qwdxgk4z 16 2 , , , cord-328753-qwdxgk4z 16 3 the the DT cord-328753-qwdxgk4z 16 4 large large JJ cord-328753-qwdxgk4z 16 5 size size NN cord-328753-qwdxgk4z 16 6 of of IN cord-328753-qwdxgk4z 16 7 the the DT cord-328753-qwdxgk4z 16 8 molecules molecule NNS cord-328753-qwdxgk4z 16 9 may may MD cord-328753-qwdxgk4z 16 10 hinder hinder VB cord-328753-qwdxgk4z 16 11 efficient efficient JJ cord-328753-qwdxgk4z 16 12 tissue tissue NN cord-328753-qwdxgk4z 16 13 penetration penetration NN cord-328753-qwdxgk4z 16 14 . . . cord-328753-qwdxgk4z 17 1 This this DT cord-328753-qwdxgk4z 17 2 obstacle obstacle NN cord-328753-qwdxgk4z 17 3 can can MD cord-328753-qwdxgk4z 17 4 be be VB cord-328753-qwdxgk4z 17 5 overcome overcome VBN cord-328753-qwdxgk4z 17 6 using use VBG cord-328753-qwdxgk4z 17 7 Fab fab JJ cord-328753-qwdxgk4z 17 8 or or CC cord-328753-qwdxgk4z 17 9 single single JJ cord-328753-qwdxgk4z 17 10 - - HYPH cord-328753-qwdxgk4z 17 11 chain chain NN cord-328753-qwdxgk4z 17 12 Fv Fv NNP cord-328753-qwdxgk4z 17 13 ( ( -LRB- cord-328753-qwdxgk4z 17 14 scFv scFv NNP cord-328753-qwdxgk4z 17 15 ) ) -RRB- cord-328753-qwdxgk4z 17 16 fragments fragment NNS cord-328753-qwdxgk4z 17 17 , , , cord-328753-qwdxgk4z 17 18 as as IN cord-328753-qwdxgk4z 17 19 they -PRON- PRP cord-328753-qwdxgk4z 17 20 are be VBP cord-328753-qwdxgk4z 17 21 three three CD cord-328753-qwdxgk4z 17 22 to to TO cord-328753-qwdxgk4z 17 23 six six CD cord-328753-qwdxgk4z 17 24 times time NNS cord-328753-qwdxgk4z 17 25 smaller small JJR cord-328753-qwdxgk4z 17 26 than than IN cord-328753-qwdxgk4z 17 27 full full JJ cord-328753-qwdxgk4z 17 28 - - HYPH cord-328753-qwdxgk4z 17 29 sized sized JJ cord-328753-qwdxgk4z 17 30 antibodies antibody NNS cord-328753-qwdxgk4z 17 31 . . . cord-328753-qwdxgk4z 18 1 However however RB cord-328753-qwdxgk4z 18 2 , , , cord-328753-qwdxgk4z 18 3 cloning clone VBG cord-328753-qwdxgk4z 18 4 these these DT cord-328753-qwdxgk4z 18 5 fragments fragment NNS cord-328753-qwdxgk4z 18 6 , , , cord-328753-qwdxgk4z 18 7 consisting consist VBG cord-328753-qwdxgk4z 18 8 of of IN cord-328753-qwdxgk4z 18 9 heavy heavy JJ cord-328753-qwdxgk4z 18 10 and and CC cord-328753-qwdxgk4z 18 11 light light JJ cord-328753-qwdxgk4z 18 12 chain chain NN cord-328753-qwdxgk4z 18 13 variable variable NN cord-328753-qwdxgk4z 18 14 regions region NNS cord-328753-qwdxgk4z 18 15 linked link VBN cord-328753-qwdxgk4z 18 16 by by IN cord-328753-qwdxgk4z 18 17 disulfide disulfide NN cord-328753-qwdxgk4z 18 18 bridges bridge NNS cord-328753-qwdxgk4z 18 19 or or CC cord-328753-qwdxgk4z 18 20 a a DT cord-328753-qwdxgk4z 18 21 linker linker NN cord-328753-qwdxgk4z 18 22 , , , cord-328753-qwdxgk4z 18 23 is be VBZ cord-328753-qwdxgk4z 18 24 challenging challenging JJ cord-328753-qwdxgk4z 18 25 and and CC cord-328753-qwdxgk4z 18 26 they -PRON- PRP cord-328753-qwdxgk4z 18 27 are be VBP cord-328753-qwdxgk4z 18 28 not not RB cord-328753-qwdxgk4z 18 29 always always RB cord-328753-qwdxgk4z 18 30 efficiently efficiently RB cord-328753-qwdxgk4z 18 31 expressed express VBN cord-328753-qwdxgk4z 18 32 [ [ -LRB- cord-328753-qwdxgk4z 18 33 1 1 CD cord-328753-qwdxgk4z 18 34 ] ] -RRB- cord-328753-qwdxgk4z 18 35 . . . cord-328753-qwdxgk4z 19 1 An an DT cord-328753-qwdxgk4z 19 2 alternative alternative JJ cord-328753-qwdxgk4z 19 3 approach approach NN cord-328753-qwdxgk4z 19 4 to to TO cord-328753-qwdxgk4z 19 5 avoid avoid VB cord-328753-qwdxgk4z 19 6 these these DT cord-328753-qwdxgk4z 19 7 pitfalls pitfall NNS cord-328753-qwdxgk4z 19 8 is be VBZ cord-328753-qwdxgk4z 19 9 the the DT cord-328753-qwdxgk4z 19 10 use use NN cord-328753-qwdxgk4z 19 11 of of IN cord-328753-qwdxgk4z 19 12 functional functional JJ cord-328753-qwdxgk4z 19 13 fragments fragment NNS cord-328753-qwdxgk4z 19 14 of of IN cord-328753-qwdxgk4z 19 15 heavy heavy JJ cord-328753-qwdxgk4z 19 16 chain chain NN cord-328753-qwdxgk4z 19 17 antibodies antibody NNS cord-328753-qwdxgk4z 19 18 , , , cord-328753-qwdxgk4z 19 19 which which WDT cord-328753-qwdxgk4z 19 20 are be VBP cord-328753-qwdxgk4z 19 21 present present JJ cord-328753-qwdxgk4z 19 22 in in IN cord-328753-qwdxgk4z 19 23 the the DT cord-328753-qwdxgk4z 19 24 serum serum NN cord-328753-qwdxgk4z 19 25 of of IN cord-328753-qwdxgk4z 19 26 animals animal NNS cord-328753-qwdxgk4z 19 27 belonging belong VBG cord-328753-qwdxgk4z 19 28 to to IN cord-328753-qwdxgk4z 19 29 the the DT cord-328753-qwdxgk4z 19 30 Camelidae Camelidae NNP cord-328753-qwdxgk4z 19 31 family family NN cord-328753-qwdxgk4z 19 32 . . . cord-328753-qwdxgk4z 20 1 They -PRON- PRP cord-328753-qwdxgk4z 20 2 interact interact VBP cord-328753-qwdxgk4z 20 3 with with IN cord-328753-qwdxgk4z 20 4 the the DT cord-328753-qwdxgk4z 20 5 antigen antigen NN cord-328753-qwdxgk4z 20 6 by by IN cord-328753-qwdxgk4z 20 7 virtue virtue NN cord-328753-qwdxgk4z 20 8 of of IN cord-328753-qwdxgk4z 20 9 one one CD cord-328753-qwdxgk4z 20 10 single single JJ cord-328753-qwdxgk4z 20 11 variable variable JJ cord-328753-qwdxgk4z 20 12 domain domain NN cord-328753-qwdxgk4z 20 13 referred refer VBN cord-328753-qwdxgk4z 20 14 to to IN cord-328753-qwdxgk4z 20 15 as as IN cord-328753-qwdxgk4z 20 16 VHHs vhh NNS cord-328753-qwdxgk4z 20 17 , , , cord-328753-qwdxgk4z 20 18 single single JJ cord-328753-qwdxgk4z 20 19 - - HYPH cord-328753-qwdxgk4z 20 20 domain domain NN cord-328753-qwdxgk4z 20 21 antibodies antibody NNS cord-328753-qwdxgk4z 20 22 ( ( -LRB- cord-328753-qwdxgk4z 20 23 sdAbs sdAbs NNP cord-328753-qwdxgk4z 20 24 ) ) -RRB- cord-328753-qwdxgk4z 20 25 , , , cord-328753-qwdxgk4z 20 26 or or CC cord-328753-qwdxgk4z 20 27 nanobodies nanobodies NNP cord-328753-qwdxgk4z 20 28 ™ ™ NN cord-328753-qwdxgk4z 20 29 ( ( -LRB- cord-328753-qwdxgk4z 20 30 trademark trademark NN cord-328753-qwdxgk4z 20 31 of of IN cord-328753-qwdxgk4z 20 32 Ablynx Ablynx NNP cord-328753-qwdxgk4z 20 33 ) ) -RRB- cord-328753-qwdxgk4z 20 34 . . . cord-328753-qwdxgk4z 21 1 They -PRON- PRP cord-328753-qwdxgk4z 21 2 combine combine VBP cord-328753-qwdxgk4z 21 3 the the DT cord-328753-qwdxgk4z 21 4 advantages advantage NNS cord-328753-qwdxgk4z 21 5 of of IN cord-328753-qwdxgk4z 21 6 both both DT cord-328753-qwdxgk4z 21 7 immunoglobulins immunoglobulin NNS cord-328753-qwdxgk4z 21 8 and and CC cord-328753-qwdxgk4z 21 9 small small JJ cord-328753-qwdxgk4z 21 10 molecules molecule NNS cord-328753-qwdxgk4z 21 11 and and CC cord-328753-qwdxgk4z 21 12 provide provide VB cord-328753-qwdxgk4z 21 13 an an DT cord-328753-qwdxgk4z 21 14 alternative alternative NN cord-328753-qwdxgk4z 21 15 to to IN cord-328753-qwdxgk4z 21 16 conventional conventional JJ cord-328753-qwdxgk4z 21 17 antibodies antibody NNS cord-328753-qwdxgk4z 21 18 and and CC cord-328753-qwdxgk4z 21 19 binders binder NNS cord-328753-qwdxgk4z 21 20 derived derive VBN cord-328753-qwdxgk4z 21 21 from from IN cord-328753-qwdxgk4z 21 22 alternative alternative JJ cord-328753-qwdxgk4z 21 23 scaffolds scaffold NNS cord-328753-qwdxgk4z 21 24 . . . cord-328753-qwdxgk4z 22 1 Sharks shark NNS cord-328753-qwdxgk4z 22 2 also also RB cord-328753-qwdxgk4z 22 3 produce produce VBP cord-328753-qwdxgk4z 22 4 a a DT cord-328753-qwdxgk4z 22 5 unique unique JJ cord-328753-qwdxgk4z 22 6 heavy heavy JJ cord-328753-qwdxgk4z 22 7 - - HYPH cord-328753-qwdxgk4z 22 8 chain chain NN cord-328753-qwdxgk4z 22 9 only only RB cord-328753-qwdxgk4z 22 10 immunoglobulin immunoglobulin NN cord-328753-qwdxgk4z 22 11 that that WDT cord-328753-qwdxgk4z 22 12 does do VBZ cord-328753-qwdxgk4z 22 13 not not RB cord-328753-qwdxgk4z 22 14 associate associate VB cord-328753-qwdxgk4z 22 15 with with IN cord-328753-qwdxgk4z 22 16 light light JJ cord-328753-qwdxgk4z 22 17 chains chain NNS cord-328753-qwdxgk4z 22 18 , , , cord-328753-qwdxgk4z 22 19 referred refer VBD cord-328753-qwdxgk4z 22 20 to to IN cord-328753-qwdxgk4z 22 21 as as IN cord-328753-qwdxgk4z 22 22 IgNAR IgNAR NNP cord-328753-qwdxgk4z 22 23 . . . cord-328753-qwdxgk4z 23 1 V v LS cord-328753-qwdxgk4z 23 2 domains domain NNS cord-328753-qwdxgk4z 23 3 of of IN cord-328753-qwdxgk4z 23 4 IgNAR IgNAR NNP cord-328753-qwdxgk4z 23 5 are be VBP cord-328753-qwdxgk4z 23 6 often often RB cord-328753-qwdxgk4z 23 7 applied apply VBN cord-328753-qwdxgk4z 23 8 in in IN cord-328753-qwdxgk4z 23 9 biotechnological biotechnological JJ cord-328753-qwdxgk4z 23 10 and and CC cord-328753-qwdxgk4z 23 11 biomedical biomedical JJ cord-328753-qwdxgk4z 23 12 fields field NNS cord-328753-qwdxgk4z 23 13 ( ( -LRB- cord-328753-qwdxgk4z 23 14 for for IN cord-328753-qwdxgk4z 23 15 a a DT cord-328753-qwdxgk4z 23 16 review review NN cord-328753-qwdxgk4z 23 17 [ [ -LRB- cord-328753-qwdxgk4z 23 18 2 2 CD cord-328753-qwdxgk4z 23 19 ] ] -RRB- cord-328753-qwdxgk4z 23 20 ) ) -RRB- cord-328753-qwdxgk4z 23 21 . . . cord-328753-qwdxgk4z 24 1 The the DT cord-328753-qwdxgk4z 24 2 Camelidae Camelidae NNP cord-328753-qwdxgk4z 24 3 family family NN cord-328753-qwdxgk4z 24 4 ( ( -LRB- cord-328753-qwdxgk4z 24 5 order order NN cord-328753-qwdxgk4z 24 6 : : : cord-328753-qwdxgk4z 24 7 Artiodactyla Artiodactyla NNP cord-328753-qwdxgk4z 24 8 ) ) -RRB- cord-328753-qwdxgk4z 24 9 consists consist VBZ cord-328753-qwdxgk4z 24 10 of of IN cord-328753-qwdxgk4z 24 11 six six CD cord-328753-qwdxgk4z 24 12 species specie NNS cord-328753-qwdxgk4z 24 13 : : : cord-328753-qwdxgk4z 24 14 dromedary dromedary NN cord-328753-qwdxgk4z 24 15 ( ( -LRB- cord-328753-qwdxgk4z 24 16 Camelus Camelus NNP cord-328753-qwdxgk4z 24 17 dromedarius dromedarius NN cord-328753-qwdxgk4z 24 18 ) ) -RRB- cord-328753-qwdxgk4z 24 19 , , , cord-328753-qwdxgk4z 24 20 Bactrian bactrian JJ cord-328753-qwdxgk4z 24 21 camel camel NN cord-328753-qwdxgk4z 24 22 ( ( -LRB- cord-328753-qwdxgk4z 24 23 Camelus Camelus NNP cord-328753-qwdxgk4z 24 24 bactrianus bactrianus NNP cord-328753-qwdxgk4z 24 25 ) ) -RRB- cord-328753-qwdxgk4z 24 26 , , , cord-328753-qwdxgk4z 24 27 llama llama FW cord-328753-qwdxgk4z 24 28 ( ( -LRB- cord-328753-qwdxgk4z 24 29 Lama Lama NNP cord-328753-qwdxgk4z 24 30 glama glama NNP cord-328753-qwdxgk4z 24 31 ) ) -RRB- cord-328753-qwdxgk4z 24 32 , , , cord-328753-qwdxgk4z 24 33 guanaco guanaco NN cord-328753-qwdxgk4z 24 34 ( ( -LRB- cord-328753-qwdxgk4z 24 35 Lama Lama NNP cord-328753-qwdxgk4z 24 36 guanicoe guanicoe NNP cord-328753-qwdxgk4z 24 37 ) ) -RRB- cord-328753-qwdxgk4z 24 38 , , , cord-328753-qwdxgk4z 24 39 alpaca alpaca NN cord-328753-qwdxgk4z 24 40 ( ( -LRB- cord-328753-qwdxgk4z 24 41 Vicugna Vicugna NNP cord-328753-qwdxgk4z 24 42 pacos pacos NNP cord-328753-qwdxgk4z 24 43 ) ) -RRB- cord-328753-qwdxgk4z 24 44 , , , cord-328753-qwdxgk4z 24 45 and and CC cord-328753-qwdxgk4z 24 46 vicuna vicuna NN cord-328753-qwdxgk4z 24 47 ( ( -LRB- cord-328753-qwdxgk4z 24 48 Vicugna Vicugna NNP cord-328753-qwdxgk4z 24 49 vicugna vicugna NNP cord-328753-qwdxgk4z 24 50 ) ) -RRB- cord-328753-qwdxgk4z 24 51 . . . cord-328753-qwdxgk4z 25 1 Animals animal NNS cord-328753-qwdxgk4z 25 2 belonging belong VBG cord-328753-qwdxgk4z 25 3 to to IN cord-328753-qwdxgk4z 25 4 this this DT cord-328753-qwdxgk4z 25 5 family family NN cord-328753-qwdxgk4z 25 6 are be VBP cord-328753-qwdxgk4z 25 7 well well RB cord-328753-qwdxgk4z 25 8 adapted adapt VBN cord-328753-qwdxgk4z 25 9 to to TO cord-328753-qwdxgk4z 25 10 live live VB cord-328753-qwdxgk4z 25 11 in in IN cord-328753-qwdxgk4z 25 12 harsh harsh JJ cord-328753-qwdxgk4z 25 13 environments environment NNS cord-328753-qwdxgk4z 25 14 , , , cord-328753-qwdxgk4z 25 15 such such JJ cord-328753-qwdxgk4z 25 16 as as IN cord-328753-qwdxgk4z 25 17 deserts desert NNS cord-328753-qwdxgk4z 25 18 or or CC cord-328753-qwdxgk4z 25 19 high high JJ cord-328753-qwdxgk4z 25 20 altitudes altitude NNS cord-328753-qwdxgk4z 25 21 [ [ -LRB- cord-328753-qwdxgk4z 25 22 3 3 CD cord-328753-qwdxgk4z 25 23 ] ] -RRB- cord-328753-qwdxgk4z 25 24 . . . cord-328753-qwdxgk4z 26 1 Ungar Ungar NNP cord-328753-qwdxgk4z 26 2 - - HYPH cord-328753-qwdxgk4z 26 3 Warom Warom NNP cord-328753-qwdxgk4z 26 4 et et NNP cord-328753-qwdxgk4z 26 5 al al NNP cord-328753-qwdxgk4z 26 6 . . . cord-328753-qwdxgk4z 27 1 [ [ -LRB- cord-328753-qwdxgk4z 27 2 4 4 CD cord-328753-qwdxgk4z 27 3 ] ] -RRB- cord-328753-qwdxgk4z 27 4 and and CC cord-328753-qwdxgk4z 27 5 Azwai Azwai NNP cord-328753-qwdxgk4z 27 6 et et NNP cord-328753-qwdxgk4z 27 7 al al NNP cord-328753-qwdxgk4z 27 8 [ [ -LRB- cord-328753-qwdxgk4z 27 9 5 5 CD cord-328753-qwdxgk4z 27 10 ] ] -RRB- cord-328753-qwdxgk4z 27 11 have have VBP cord-328753-qwdxgk4z 27 12 isolated isolate VBN cord-328753-qwdxgk4z 27 13 low low JJ cord-328753-qwdxgk4z 27 14 molecular molecular JJ cord-328753-qwdxgk4z 27 15 weight weight NN cord-328753-qwdxgk4z 27 16 Ig ig NN cord-328753-qwdxgk4z 27 17 - - HYPH cord-328753-qwdxgk4z 27 18 like like JJ cord-328753-qwdxgk4z 27 19 proteins protein NNS cord-328753-qwdxgk4z 27 20 from from IN cord-328753-qwdxgk4z 27 21 dromedary dromedary NN cord-328753-qwdxgk4z 27 22 serum serum NN cord-328753-qwdxgk4z 27 23 . . . cord-328753-qwdxgk4z 28 1 However however RB cord-328753-qwdxgk4z 28 2 , , , cord-328753-qwdxgk4z 28 3 the the DT cord-328753-qwdxgk4z 28 4 detailed detailed JJ cord-328753-qwdxgk4z 28 5 characterization characterization NN cord-328753-qwdxgk4z 28 6 and and CC cord-328753-qwdxgk4z 28 7 demonstration demonstration NN cord-328753-qwdxgk4z 28 8 of of IN cord-328753-qwdxgk4z 28 9 the the DT cord-328753-qwdxgk4z 28 10 potential potential JJ cord-328753-qwdxgk4z 28 11 usefulness usefulness NN cord-328753-qwdxgk4z 28 12 of of IN cord-328753-qwdxgk4z 28 13 these these DT cord-328753-qwdxgk4z 28 14 proteins protein NNS cord-328753-qwdxgk4z 28 15 stemmed stem VBD cord-328753-qwdxgk4z 28 16 from from IN cord-328753-qwdxgk4z 28 17 the the DT cord-328753-qwdxgk4z 28 18 work work NN cord-328753-qwdxgk4z 28 19 of of IN cord-328753-qwdxgk4z 28 20 the the DT cord-328753-qwdxgk4z 28 21 Hamers Hamers NNP cord-328753-qwdxgk4z 28 22 laboratory laboratory NN cord-328753-qwdxgk4z 28 23 in in IN cord-328753-qwdxgk4z 28 24 the the DT cord-328753-qwdxgk4z 28 25 Free Free NNP cord-328753-qwdxgk4z 28 26 University University NNP cord-328753-qwdxgk4z 28 27 of of IN cord-328753-qwdxgk4z 28 28 Brussels Brussels NNP cord-328753-qwdxgk4z 28 29 [ [ -LRB- cord-328753-qwdxgk4z 28 30 6 6 CD cord-328753-qwdxgk4z 28 31 ] ] -RRB- cord-328753-qwdxgk4z 28 32 . . . cord-328753-qwdxgk4z 29 1 The the DT cord-328753-qwdxgk4z 29 2 authors author NNS cord-328753-qwdxgk4z 29 3 demonstrated demonstrate VBD cord-328753-qwdxgk4z 29 4 that that IN cord-328753-qwdxgk4z 29 5 these these DT cord-328753-qwdxgk4z 29 6 unusual unusual JJ cord-328753-qwdxgk4z 29 7 proteins protein NNS cord-328753-qwdxgk4z 29 8 are be VBP cord-328753-qwdxgk4z 29 9 " " `` cord-328753-qwdxgk4z 29 10 heavy heavy JJ cord-328753-qwdxgk4z 29 11 - - HYPH cord-328753-qwdxgk4z 29 12 chain chain NN cord-328753-qwdxgk4z 29 13 only only RB cord-328753-qwdxgk4z 29 14 antibodies antibody NNS cord-328753-qwdxgk4z 29 15 ' ' POS cord-328753-qwdxgk4z 29 16 ' ' '' cord-328753-qwdxgk4z 29 17 ( ( -LRB- cord-328753-qwdxgk4z 29 18 HCAbs HCAbs NNP cord-328753-qwdxgk4z 29 19 ) ) -RRB- cord-328753-qwdxgk4z 29 20 , , , cord-328753-qwdxgk4z 29 21 devoid devoid JJ cord-328753-qwdxgk4z 29 22 of of IN cord-328753-qwdxgk4z 29 23 light light JJ cord-328753-qwdxgk4z 29 24 chain chain NN cord-328753-qwdxgk4z 29 25 . . . cord-328753-qwdxgk4z 30 1 These these DT cord-328753-qwdxgk4z 30 2 antibodies antibody NNS cord-328753-qwdxgk4z 30 3 form form VBP cord-328753-qwdxgk4z 30 4 homodimers homodimer NNS cord-328753-qwdxgk4z 30 5 and and CC cord-328753-qwdxgk4z 30 6 interact interact VB cord-328753-qwdxgk4z 30 7 with with IN cord-328753-qwdxgk4z 30 8 antigens antigen NNS cord-328753-qwdxgk4z 30 9 by by IN cord-328753-qwdxgk4z 30 10 virtue virtue NN cord-328753-qwdxgk4z 30 11 of of IN cord-328753-qwdxgk4z 30 12 only only RB cord-328753-qwdxgk4z 30 13 one one CD cord-328753-qwdxgk4z 30 14 single single JJ cord-328753-qwdxgk4z 30 15 variable variable JJ cord-328753-qwdxgk4z 30 16 domain domain NN cord-328753-qwdxgk4z 30 17 , , , cord-328753-qwdxgk4z 30 18 referred refer VBD cord-328753-qwdxgk4z 30 19 to to IN cord-328753-qwdxgk4z 30 20 as as IN cord-328753-qwdxgk4z 30 21 VHH VHH NNP cord-328753-qwdxgk4z 30 22 ( ( -LRB- cord-328753-qwdxgk4z 30 23 VH VH NNP cord-328753-qwdxgk4z 30 24 domain domain NN cord-328753-qwdxgk4z 30 25 of of IN cord-328753-qwdxgk4z 30 26 heavy heavy JJ cord-328753-qwdxgk4z 30 27 - - HYPH cord-328753-qwdxgk4z 30 28 chain chain NN cord-328753-qwdxgk4z 30 29 antibodies antibody NNS cord-328753-qwdxgk4z 30 30 ) ) -RRB- cord-328753-qwdxgk4z 30 31 to to TO cord-328753-qwdxgk4z 30 32 distinguish distinguish VB cord-328753-qwdxgk4z 30 33 it -PRON- PRP cord-328753-qwdxgk4z 30 34 from from IN cord-328753-qwdxgk4z 30 35 conventional conventional JJ cord-328753-qwdxgk4z 30 36 VH VH NNP cord-328753-qwdxgk4z 30 37 [ [ -LRB- cord-328753-qwdxgk4z 30 38 7 7 CD cord-328753-qwdxgk4z 30 39 ] ] -RRB- cord-328753-qwdxgk4z 30 40 . . . cord-328753-qwdxgk4z 31 1 In in IN cord-328753-qwdxgk4z 31 2 contrast contrast NN cord-328753-qwdxgk4z 31 3 to to IN cord-328753-qwdxgk4z 31 4 conventional conventional JJ cord-328753-qwdxgk4z 31 5 antibodies antibody NNS cord-328753-qwdxgk4z 31 6 , , , cord-328753-qwdxgk4z 31 7 HCAbs HCAbs NNPS cord-328753-qwdxgk4z 31 8 do do VBP cord-328753-qwdxgk4z 31 9 not not RB cord-328753-qwdxgk4z 31 10 possess possess VB cord-328753-qwdxgk4z 31 11 the the DT cord-328753-qwdxgk4z 31 12 CH1 CH1 NNP cord-328753-qwdxgk4z 31 13 domain domain NN cord-328753-qwdxgk4z 31 14 [ [ -LRB- cord-328753-qwdxgk4z 31 15 6 6 CD cord-328753-qwdxgk4z 31 16 ] ] -RRB- cord-328753-qwdxgk4z 31 17 . . . cord-328753-qwdxgk4z 32 1 The the DT cord-328753-qwdxgk4z 32 2 active active JJ cord-328753-qwdxgk4z 32 3 antigen antigen NN cord-328753-qwdxgk4z 32 4 - - HYPH cord-328753-qwdxgk4z 32 5 binding bind VBG cord-328753-qwdxgk4z 32 6 fragment fragment NN cord-328753-qwdxgk4z 32 7 of of IN cord-328753-qwdxgk4z 32 8 heavy heavy JJ cord-328753-qwdxgk4z 32 9 chain chain NN cord-328753-qwdxgk4z 32 10 antibodies antibody NNS cord-328753-qwdxgk4z 32 11 can can MD cord-328753-qwdxgk4z 32 12 be be VB cord-328753-qwdxgk4z 32 13 cloned clone VBN cord-328753-qwdxgk4z 32 14 and and CC cord-328753-qwdxgk4z 32 15 expressed express VBN cord-328753-qwdxgk4z 32 16 in in IN cord-328753-qwdxgk4z 32 17 the the DT cord-328753-qwdxgk4z 32 18 form form NN cord-328753-qwdxgk4z 32 19 of of IN cord-328753-qwdxgk4z 32 20 VHH vhh NN cord-328753-qwdxgk4z 32 21 , , , cord-328753-qwdxgk4z 32 22 which which WDT cord-328753-qwdxgk4z 32 23 consists consist VBZ cord-328753-qwdxgk4z 32 24 of of IN cord-328753-qwdxgk4z 32 25 only only RB cord-328753-qwdxgk4z 32 26 one one CD cord-328753-qwdxgk4z 32 27 domain domain NN cord-328753-qwdxgk4z 32 28 ( ( -LRB- cord-328753-qwdxgk4z 32 29 Fig Fig NNP cord-328753-qwdxgk4z 32 30 . . . cord-328753-qwdxgk4z 32 31 1 1 CD cord-328753-qwdxgk4z 32 32 ) ) -RRB- cord-328753-qwdxgk4z 32 33 . . . cord-328753-qwdxgk4z 33 1 The the DT cord-328753-qwdxgk4z 33 2 percentage percentage NN cord-328753-qwdxgk4z 33 3 of of IN cord-328753-qwdxgk4z 33 4 HCAbs HCAbs NNPS cord-328753-qwdxgk4z 33 5 in in IN cord-328753-qwdxgk4z 33 6 the the DT cord-328753-qwdxgk4z 33 7 bloodstream bloodstream NN cord-328753-qwdxgk4z 33 8 of of IN cord-328753-qwdxgk4z 33 9 camelids camelid NNS cord-328753-qwdxgk4z 33 10 varies vary VBZ cord-328753-qwdxgk4z 33 11 greatly greatly RB cord-328753-qwdxgk4z 33 12 among among IN cord-328753-qwdxgk4z 33 13 species specie NNS cord-328753-qwdxgk4z 33 14 . . . cord-328753-qwdxgk4z 34 1 It -PRON- PRP cord-328753-qwdxgk4z 34 2 can can MD cord-328753-qwdxgk4z 34 3 reach reach VB cord-328753-qwdxgk4z 34 4 a a DT cord-328753-qwdxgk4z 34 5 relatively relatively RB cord-328753-qwdxgk4z 34 6 high high JJ cord-328753-qwdxgk4z 34 7 level level NN cord-328753-qwdxgk4z 34 8 in in IN cord-328753-qwdxgk4z 34 9 camels camel NNS cord-328753-qwdxgk4z 34 10 , , , cord-328753-qwdxgk4z 34 11 ranging range VBG cord-328753-qwdxgk4z 34 12 from from IN cord-328753-qwdxgk4z 34 13 50 50 CD cord-328753-qwdxgk4z 34 14 % % NN cord-328753-qwdxgk4z 34 15 to to TO cord-328753-qwdxgk4z 34 16 80 80 CD cord-328753-qwdxgk4z 34 17 % % NN cord-328753-qwdxgk4z 34 18 , , , cord-328753-qwdxgk4z 34 19 whereas whereas IN cord-328753-qwdxgk4z 34 20 the the DT cord-328753-qwdxgk4z 34 21 maximum maximum JJ cord-328753-qwdxgk4z 34 22 level level NN cord-328753-qwdxgk4z 34 23 is be VBZ cord-328753-qwdxgk4z 34 24 45 45 CD cord-328753-qwdxgk4z 34 25 % % NN cord-328753-qwdxgk4z 34 26 in in IN cord-328753-qwdxgk4z 34 27 South south JJ cord-328753-qwdxgk4z 34 28 American american JJ cord-328753-qwdxgk4z 34 29 camelid camelid NN cord-328753-qwdxgk4z 34 30 species specie NNS cord-328753-qwdxgk4z 34 31 [ [ -LRB- cord-328753-qwdxgk4z 34 32 8 8 CD cord-328753-qwdxgk4z 34 33 ] ] -RRB- cord-328753-qwdxgk4z 34 34 . . . cord-328753-qwdxgk4z 35 1 Despite despite IN cord-328753-qwdxgk4z 35 2 the the DT cord-328753-qwdxgk4z 35 3 absence absence NN cord-328753-qwdxgk4z 35 4 of of IN cord-328753-qwdxgk4z 35 5 light light JJ cord-328753-qwdxgk4z 35 6 chains chain NNS cord-328753-qwdxgk4z 35 7 , , , cord-328753-qwdxgk4z 35 8 the the DT cord-328753-qwdxgk4z 35 9 heavy heavy JJ cord-328753-qwdxgk4z 35 10 - - HYPH cord-328753-qwdxgk4z 35 11 chain chain NN cord-328753-qwdxgk4z 35 12 antibodies antibody NNS cord-328753-qwdxgk4z 35 13 exhibit exhibit VBP cord-328753-qwdxgk4z 35 14 a a DT cord-328753-qwdxgk4z 35 15 broad broad JJ cord-328753-qwdxgk4z 35 16 antigen antigen NN cord-328753-qwdxgk4z 35 17 - - HYPH cord-328753-qwdxgk4z 35 18 binding bind VBG cord-328753-qwdxgk4z 35 19 repertoire repertoire NN cord-328753-qwdxgk4z 35 20 . . . cord-328753-qwdxgk4z 36 1 They -PRON- PRP cord-328753-qwdxgk4z 36 2 exhibit exhibit VBP cord-328753-qwdxgk4z 36 3 specific specific JJ cord-328753-qwdxgk4z 36 4 characteristics characteristic NNS cord-328753-qwdxgk4z 36 5 , , , cord-328753-qwdxgk4z 36 6 such such JJ cord-328753-qwdxgk4z 36 7 as as IN cord-328753-qwdxgk4z 36 8 the the DT cord-328753-qwdxgk4z 36 9 substitution substitution NN cord-328753-qwdxgk4z 36 10 of of IN cord-328753-qwdxgk4z 36 11 three three CD cord-328753-qwdxgk4z 36 12 to to TO cord-328753-qwdxgk4z 36 13 four four CD cord-328753-qwdxgk4z 36 14 hydrophobic hydrophobic JJ cord-328753-qwdxgk4z 36 15 residues residue NNS cord-328753-qwdxgk4z 36 16 ( ( -LRB- cord-328753-qwdxgk4z 36 17 which which WDT cord-328753-qwdxgk4z 36 18 interact interact VBP cord-328753-qwdxgk4z 36 19 with with IN cord-328753-qwdxgk4z 36 20 the the DT cord-328753-qwdxgk4z 36 21 VL VL NNP cord-328753-qwdxgk4z 36 22 in in IN cord-328753-qwdxgk4z 36 23 conventional conventional JJ cord-328753-qwdxgk4z 36 24 antibodies antibody NNS cord-328753-qwdxgk4z 36 25 ) ) -RRB- cord-328753-qwdxgk4z 36 26 by by IN cord-328753-qwdxgk4z 36 27 more more JJR cord-328753-qwdxgk4z 36 28 hydrophilic hydrophilic JJ cord-328753-qwdxgk4z 36 29 amino amino JJ cord-328753-qwdxgk4z 36 30 acids acid NNS cord-328753-qwdxgk4z 36 31 . . . cord-328753-qwdxgk4z 37 1 VH VH NNP cord-328753-qwdxgk4z 37 2 possess possess VBP cord-328753-qwdxgk4z 37 3 the the DT cord-328753-qwdxgk4z 37 4 conserved conserve VBN cord-328753-qwdxgk4z 37 5 Val37 Val37 NNP cord-328753-qwdxgk4z 37 6 , , , cord-328753-qwdxgk4z 37 7 Gly44 Gly44 NNP cord-328753-qwdxgk4z 37 8 , , , cord-328753-qwdxgk4z 37 9 Leu45 Leu45 NNP cord-328753-qwdxgk4z 37 10 and and CC cord-328753-qwdxgk4z 37 11 Trp47 Trp47 NNP cord-328753-qwdxgk4z 37 12 while while IN cord-328753-qwdxgk4z 37 13 in in IN cord-328753-qwdxgk4z 37 14 VHH vhh NN cord-328753-qwdxgk4z 37 15 , , , cord-328753-qwdxgk4z 37 16 these these DT cord-328753-qwdxgk4z 37 17 amino amino NN cord-328753-qwdxgk4z 37 18 acids acid NNS cord-328753-qwdxgk4z 37 19 are be VBP cord-328753-qwdxgk4z 37 20 often often RB cord-328753-qwdxgk4z 37 21 substituted substitute VBN cord-328753-qwdxgk4z 37 22 ( ( -LRB- cord-328753-qwdxgk4z 37 23 Val37Phe val37phe NN cord-328753-qwdxgk4z 37 24 or or CC cord-328753-qwdxgk4z 37 25 Val37Tyr val37tyr NN cord-328753-qwdxgk4z 37 26 , , , cord-328753-qwdxgk4z 37 27 Gly44Glu gly44glu JJ cord-328753-qwdxgk4z 37 28 , , , cord-328753-qwdxgk4z 37 29 Leu45Arg leu45arg NN cord-328753-qwdxgk4z 37 30 and and CC cord-328753-qwdxgk4z 37 31 Trp47Gly trp47gly NN cord-328753-qwdxgk4z 37 32 ) ) -RRB- cord-328753-qwdxgk4z 38 1 [ [ -LRB- cord-328753-qwdxgk4z 38 2 9 9 CD cord-328753-qwdxgk4z 38 3 ] ] -RRB- cord-328753-qwdxgk4z 38 4 [ [ -LRB- cord-328753-qwdxgk4z 38 5 10 10 CD cord-328753-qwdxgk4z 38 6 ] ] -RRB- cord-328753-qwdxgk4z 38 7 [ [ -LRB- cord-328753-qwdxgk4z 38 8 11 11 CD cord-328753-qwdxgk4z 38 9 ] ] -RRB- cord-328753-qwdxgk4z 38 10 . . . cord-328753-qwdxgk4z 39 1 Furthermore furthermore RB cord-328753-qwdxgk4z 39 2 , , , cord-328753-qwdxgk4z 39 3 the the DT cord-328753-qwdxgk4z 39 4 complementarity complementarity NN cord-328753-qwdxgk4z 39 5 determining determine VBG cord-328753-qwdxgk4z 39 6 regions region NNS cord-328753-qwdxgk4z 39 7 ( ( -LRB- cord-328753-qwdxgk4z 39 8 CDRs CDRs NNP cord-328753-qwdxgk4z 39 9 ) ) -RRB- cord-328753-qwdxgk4z 39 10 of of IN cord-328753-qwdxgk4z 39 11 VHHs vhh NNS cord-328753-qwdxgk4z 39 12 , , , cord-328753-qwdxgk4z 39 13 and and CC cord-328753-qwdxgk4z 39 14 especially especially RB cord-328753-qwdxgk4z 39 15 CDR3 CDR3 NNP cord-328753-qwdxgk4z 39 16 , , , cord-328753-qwdxgk4z 39 17 are be VBP cord-328753-qwdxgk4z 39 18 statistically statistically RB cord-328753-qwdxgk4z 39 19 longer long JJR cord-328753-qwdxgk4z 39 20 than than IN cord-328753-qwdxgk4z 39 21 those those DT cord-328753-qwdxgk4z 39 22 of of IN cord-328753-qwdxgk4z 39 23 conventional conventional JJ cord-328753-qwdxgk4z 39 24 VH VH NNP cord-328753-qwdxgk4z 39 25 - - HYPH cord-328753-qwdxgk4z 39 26 VL VL NNP cord-328753-qwdxgk4z 39 27 antibodies antibody NNS cord-328753-qwdxgk4z 39 28 [ [ -LRB- cord-328753-qwdxgk4z 39 29 12 12 CD cord-328753-qwdxgk4z 39 30 ] ] -RRB- cord-328753-qwdxgk4z 39 31 . . . cord-328753-qwdxgk4z 40 1 Over over IN cord-328753-qwdxgk4z 40 2 the the DT cord-328753-qwdxgk4z 40 3 last last JJ cord-328753-qwdxgk4z 40 4 decades decade NNS cord-328753-qwdxgk4z 40 5 , , , cord-328753-qwdxgk4z 40 6 VHHs vhh NNS cord-328753-qwdxgk4z 40 7 have have VBP cord-328753-qwdxgk4z 40 8 received receive VBN cord-328753-qwdxgk4z 40 9 progressively progressively RB cord-328753-qwdxgk4z 40 10 greater great JJR cord-328753-qwdxgk4z 40 11 interest interest NN cord-328753-qwdxgk4z 40 12 from from IN cord-328753-qwdxgk4z 40 13 the the DT cord-328753-qwdxgk4z 40 14 pharmaceutical pharmaceutical NN cord-328753-qwdxgk4z 40 15 and and CC cord-328753-qwdxgk4z 40 16 biotechnology biotechnology NN cord-328753-qwdxgk4z 40 17 industries industry NNS cord-328753-qwdxgk4z 40 18 , , , cord-328753-qwdxgk4z 40 19 due due IN cord-328753-qwdxgk4z 40 20 to to IN cord-328753-qwdxgk4z 40 21 their -PRON- PRP$ cord-328753-qwdxgk4z 40 22 specific specific JJ cord-328753-qwdxgk4z 40 23 properties property NNS cord-328753-qwdxgk4z 40 24 . . . cord-328753-qwdxgk4z 41 1 Indeed indeed RB cord-328753-qwdxgk4z 41 2 , , , cord-328753-qwdxgk4z 41 3 VHHs vhh NNS cord-328753-qwdxgk4z 41 4 provide provide VBP cord-328753-qwdxgk4z 41 5 the the DT cord-328753-qwdxgk4z 41 6 following follow VBG cord-328753-qwdxgk4z 41 7 advantages advantage NNS cord-328753-qwdxgk4z 41 8 over over IN cord-328753-qwdxgk4z 41 9 conventional conventional JJ cord-328753-qwdxgk4z 41 10 antibodies antibody NNS cord-328753-qwdxgk4z 41 11 and and CC cord-328753-qwdxgk4z 41 12 their -PRON- PRP$ cord-328753-qwdxgk4z 41 13 recombinant recombinant JJ cord-328753-qwdxgk4z 41 14 fragments fragment NNS cord-328753-qwdxgk4z 41 15 : : : cord-328753-qwdxgk4z 41 16 -VHHs -vhhs CD cord-328753-qwdxgk4z 41 17 are be VBP cord-328753-qwdxgk4z 41 18 weakly weakly RB cord-328753-qwdxgk4z 41 19 immunogenic immunogenic JJ cord-328753-qwdxgk4z 41 20 in in IN cord-328753-qwdxgk4z 41 21 humans human NNS cord-328753-qwdxgk4z 41 22 , , , cord-328753-qwdxgk4z 41 23 because because IN cord-328753-qwdxgk4z 41 24 the the DT cord-328753-qwdxgk4z 41 25 genes gene NNS cord-328753-qwdxgk4z 41 26 encoding encode VBG cord-328753-qwdxgk4z 41 27 them -PRON- PRP cord-328753-qwdxgk4z 41 28 share share VBP cord-328753-qwdxgk4z 41 29 high high JJ cord-328753-qwdxgk4z 41 30 sequence sequence NN cord-328753-qwdxgk4z 41 31 homology homology NN cord-328753-qwdxgk4z 41 32 with with IN cord-328753-qwdxgk4z 41 33 genes gene NNS cord-328753-qwdxgk4z 41 34 belonging belong VBG cord-328753-qwdxgk4z 41 35 to to IN cord-328753-qwdxgk4z 41 36 human human JJ cord-328753-qwdxgk4z 41 37 VH VH NNP cord-328753-qwdxgk4z 41 38 families family NNS cord-328753-qwdxgk4z 41 39 3 3 CD cord-328753-qwdxgk4z 41 40 and and CC cord-328753-qwdxgk4z 41 41 4 4 CD cord-328753-qwdxgk4z 41 42 [ [ -LRB- cord-328753-qwdxgk4z 41 43 13 13 CD cord-328753-qwdxgk4z 41 44 , , , cord-328753-qwdxgk4z 41 45 14 14 CD cord-328753-qwdxgk4z 41 46 ] ] -RRB- cord-328753-qwdxgk4z 41 47 . . . cord-328753-qwdxgk4z 42 1 -VHHs -VHHs : cord-328753-qwdxgk4z 42 2 consist consist VBP cord-328753-qwdxgk4z 42 3 of of IN cord-328753-qwdxgk4z 42 4 only only RB cord-328753-qwdxgk4z 42 5 one one CD cord-328753-qwdxgk4z 42 6 domain domain NN cord-328753-qwdxgk4z 42 7 . . . cord-328753-qwdxgk4z 43 1 They -PRON- PRP cord-328753-qwdxgk4z 43 2 can can MD cord-328753-qwdxgk4z 43 3 thus thus RB cord-328753-qwdxgk4z 43 4 be be VB cord-328753-qwdxgk4z 43 5 easily easily RB cord-328753-qwdxgk4z 43 6 engineered engineer VBN cord-328753-qwdxgk4z 43 7 , , , cord-328753-qwdxgk4z 43 8 cloned clone VBN cord-328753-qwdxgk4z 43 9 , , , cord-328753-qwdxgk4z 43 10 and and CC cord-328753-qwdxgk4z 43 11 expressed express VBN cord-328753-qwdxgk4z 43 12 with with IN cord-328753-qwdxgk4z 43 13 high high JJ cord-328753-qwdxgk4z 43 14 yields yield NNS cord-328753-qwdxgk4z 43 15 using use VBG cord-328753-qwdxgk4z 43 16 various various JJ cord-328753-qwdxgk4z 43 17 expression expression NN cord-328753-qwdxgk4z 43 18 systems system NNS cord-328753-qwdxgk4z 43 19 [ [ -LRB- cord-328753-qwdxgk4z 43 20 15 15 CD cord-328753-qwdxgk4z 43 21 ] ] -RRB- cord-328753-qwdxgk4z 43 22 . . . cord-328753-qwdxgk4z 44 1 -VHHs -VHHs : cord-328753-qwdxgk4z 44 2 are be VBP cord-328753-qwdxgk4z 44 3 highly highly RB cord-328753-qwdxgk4z 44 4 soluble soluble JJ cord-328753-qwdxgk4z 44 5 and and CC cord-328753-qwdxgk4z 44 6 stable stable JJ cord-328753-qwdxgk4z 44 7 , , , cord-328753-qwdxgk4z 44 8 even even RB cord-328753-qwdxgk4z 44 9 under under IN cord-328753-qwdxgk4z 44 10 denaturing denaturing JJ cord-328753-qwdxgk4z 44 11 conditions condition NNS cord-328753-qwdxgk4z 44 12 or or CC cord-328753-qwdxgk4z 44 13 high high JJ cord-328753-qwdxgk4z 44 14 temperatures temperature NNS cord-328753-qwdxgk4z 44 15 [ [ -LRB- cord-328753-qwdxgk4z 44 16 16 16 CD cord-328753-qwdxgk4z 44 17 ] ] -RRB- cord-328753-qwdxgk4z 44 18 . . . cord-328753-qwdxgk4z 45 1 -The -The : cord-328753-qwdxgk4z 45 2 high high JJ cord-328753-qwdxgk4z 45 3 variability variability NN cord-328753-qwdxgk4z 45 4 of of IN cord-328753-qwdxgk4z 45 5 the the DT cord-328753-qwdxgk4z 45 6 length length NN cord-328753-qwdxgk4z 45 7 and and CC cord-328753-qwdxgk4z 45 8 sequence sequence NN cord-328753-qwdxgk4z 45 9 of of IN cord-328753-qwdxgk4z 45 10 VHHs vhh NNS cord-328753-qwdxgk4z 45 11 allows allow VBZ cord-328753-qwdxgk4z 45 12 them -PRON- PRP cord-328753-qwdxgk4z 45 13 to to TO cord-328753-qwdxgk4z 45 14 recognize recognize VB cord-328753-qwdxgk4z 45 15 a a DT cord-328753-qwdxgk4z 45 16 variety variety NN cord-328753-qwdxgk4z 45 17 of of IN cord-328753-qwdxgk4z 45 18 protein protein NN cord-328753-qwdxgk4z 45 19 epitopes epitope NNS cord-328753-qwdxgk4z 45 20 , , , cord-328753-qwdxgk4z 45 21 located locate VBN cord-328753-qwdxgk4z 45 22 not not RB cord-328753-qwdxgk4z 45 23 only only RB cord-328753-qwdxgk4z 45 24 on on IN cord-328753-qwdxgk4z 45 25 the the DT cord-328753-qwdxgk4z 45 26 surface surface NN cord-328753-qwdxgk4z 45 27 of of IN cord-328753-qwdxgk4z 45 28 a a DT cord-328753-qwdxgk4z 45 29 protein protein NN cord-328753-qwdxgk4z 45 30 [ [ -LRB- cord-328753-qwdxgk4z 45 31 17 17 CD cord-328753-qwdxgk4z 45 32 ] ] -RRB- cord-328753-qwdxgk4z 45 33 , , , cord-328753-qwdxgk4z 45 34 but but CC cord-328753-qwdxgk4z 45 35 also also RB cord-328753-qwdxgk4z 45 36 buried bury VBD cord-328753-qwdxgk4z 45 37 deep deep RB cord-328753-qwdxgk4z 45 38 in in IN cord-328753-qwdxgk4z 45 39 the the DT cord-328753-qwdxgk4z 45 40 clefts cleft NNS cord-328753-qwdxgk4z 45 41 [ [ -LRB- cord-328753-qwdxgk4z 45 42 18 18 CD cord-328753-qwdxgk4z 45 43 ] ] -RRB- cord-328753-qwdxgk4z 45 44 . . . cord-328753-qwdxgk4z 46 1 VHHs vhh NNS cord-328753-qwdxgk4z 46 2 have have VBP cord-328753-qwdxgk4z 46 3 been be VBN cord-328753-qwdxgk4z 46 4 shown show VBN cord-328753-qwdxgk4z 46 5 to to TO cord-328753-qwdxgk4z 46 6 recognize recognize VB cord-328753-qwdxgk4z 46 7 a a DT cord-328753-qwdxgk4z 46 8 wide wide JJ cord-328753-qwdxgk4z 46 9 range range NN cord-328753-qwdxgk4z 46 10 of of IN cord-328753-qwdxgk4z 46 11 epitope epitope NN cord-328753-qwdxgk4z 46 12 types type NNS cord-328753-qwdxgk4z 46 13 , , , cord-328753-qwdxgk4z 46 14 from from IN cord-328753-qwdxgk4z 46 15 small small JJ cord-328753-qwdxgk4z 46 16 haptens hapten NNS cord-328753-qwdxgk4z 46 17 [ [ -LRB- cord-328753-qwdxgk4z 46 18 16 16 CD cord-328753-qwdxgk4z 46 19 , , , cord-328753-qwdxgk4z 46 20 19 19 CD cord-328753-qwdxgk4z 46 21 ] ] -RRB- cord-328753-qwdxgk4z 46 22 to to IN cord-328753-qwdxgk4z 46 23 the the DT cord-328753-qwdxgk4z 46 24 binding bind VBG cord-328753-qwdxgk4z 46 25 sites site NNS cord-328753-qwdxgk4z 46 26 of of IN cord-328753-qwdxgk4z 46 27 enzymes enzyme NNS cord-328753-qwdxgk4z 46 28 [ [ -LRB- cord-328753-qwdxgk4z 46 29 17 17 CD cord-328753-qwdxgk4z 46 30 , , , cord-328753-qwdxgk4z 46 31 20 20 CD cord-328753-qwdxgk4z 46 32 ] ] -RRB- cord-328753-qwdxgk4z 46 33 , , , cord-328753-qwdxgk4z 46 34 and and CC cord-328753-qwdxgk4z 46 35 can can MD cord-328753-qwdxgk4z 46 36 bind bind VB cord-328753-qwdxgk4z 46 37 epitopes epitope NNS cord-328753-qwdxgk4z 46 38 that that WDT cord-328753-qwdxgk4z 46 39 can can MD cord-328753-qwdxgk4z 46 40 not not RB cord-328753-qwdxgk4z 46 41 be be VB cord-328753-qwdxgk4z 46 42 recognized recognize VBN cord-328753-qwdxgk4z 46 43 by by IN cord-328753-qwdxgk4z 46 44 conventional conventional JJ cord-328753-qwdxgk4z 46 45 antibodies antibody NNS cord-328753-qwdxgk4z 46 46 [ [ -LRB- cord-328753-qwdxgk4z 46 47 21 21 CD cord-328753-qwdxgk4z 46 48 ] ] -RRB- cord-328753-qwdxgk4z 46 49 . . . cord-328753-qwdxgk4z 47 1 -The -the DT cord-328753-qwdxgk4z 47 2 small small JJ cord-328753-qwdxgk4z 47 3 size size NN cord-328753-qwdxgk4z 47 4 and and CC cord-328753-qwdxgk4z 47 5 basic basic JJ cord-328753-qwdxgk4z 47 6 isolectric isolectric JJ cord-328753-qwdxgk4z 47 7 point point NN cord-328753-qwdxgk4z 47 8 of of IN cord-328753-qwdxgk4z 47 9 VHHs vhh NNS cord-328753-qwdxgk4z 47 10 allows allow VBZ cord-328753-qwdxgk4z 47 11 them -PRON- PRP cord-328753-qwdxgk4z 47 12 to to TO cord-328753-qwdxgk4z 47 13 penetrate penetrate VB cord-328753-qwdxgk4z 47 14 tissues tissue NNS cord-328753-qwdxgk4z 47 15 , , , cord-328753-qwdxgk4z 47 16 pass pass VB cord-328753-qwdxgk4z 47 17 through through IN cord-328753-qwdxgk4z 47 18 barriers barrier NNS cord-328753-qwdxgk4z 47 19 , , , cord-328753-qwdxgk4z 47 20 such such JJ cord-328753-qwdxgk4z 47 21 as as IN cord-328753-qwdxgk4z 47 22 the the DT cord-328753-qwdxgk4z 47 23 blood blood NN cord-328753-qwdxgk4z 47 24 - - HYPH cord-328753-qwdxgk4z 47 25 brain brain NN cord-328753-qwdxgk4z 47 26 barrier barrier NN cord-328753-qwdxgk4z 47 27 [ [ -LRB- cord-328753-qwdxgk4z 47 28 22 22 CD cord-328753-qwdxgk4z 47 29 ] ] -RRB- cord-328753-qwdxgk4z 47 30 [ [ -LRB- cord-328753-qwdxgk4z 47 31 23 23 CD cord-328753-qwdxgk4z 47 32 ] ] -RRB- cord-328753-qwdxgk4z 47 33 [ [ -LRB- cord-328753-qwdxgk4z 47 34 24 24 CD cord-328753-qwdxgk4z 47 35 ] ] -RRB- cord-328753-qwdxgk4z 47 36 [ [ -LRB- cord-328753-qwdxgk4z 47 37 25 25 CD cord-328753-qwdxgk4z 47 38 ] ] -RRB- cord-328753-qwdxgk4z 47 39 [ [ -LRB- cord-328753-qwdxgk4z 47 40 26 26 CD cord-328753-qwdxgk4z 47 41 ] ] -RRB- cord-328753-qwdxgk4z 47 42 , , , cord-328753-qwdxgk4z 47 43 and and CC cord-328753-qwdxgk4z 47 44 bind bind VB cord-328753-qwdxgk4z 47 45 intracellular intracellular JJ cord-328753-qwdxgk4z 47 46 antigens antigen NNS cord-328753-qwdxgk4z 47 47 . . . cord-328753-qwdxgk4z 48 1 -VHHs -VHHs : cord-328753-qwdxgk4z 48 2 can can MD cord-328753-qwdxgk4z 48 3 be be VB cord-328753-qwdxgk4z 48 4 efficiently efficiently RB cord-328753-qwdxgk4z 48 5 functionalized functionalize VBN cord-328753-qwdxgk4z 48 6 [ [ -LRB- cord-328753-qwdxgk4z 48 7 27 27 CD cord-328753-qwdxgk4z 48 8 ] ] -RRB- cord-328753-qwdxgk4z 49 1 [ [ -LRB- cord-328753-qwdxgk4z 49 2 28 28 CD cord-328753-qwdxgk4z 49 3 ] ] -RRB- cord-328753-qwdxgk4z 49 4 [ [ -LRB- cord-328753-qwdxgk4z 49 5 29 29 CD cord-328753-qwdxgk4z 49 6 ] ] -RRB- cord-328753-qwdxgk4z 49 7 and and CC cord-328753-qwdxgk4z 49 8 are be VBP cord-328753-qwdxgk4z 49 9 widely widely RB cord-328753-qwdxgk4z 49 10 used use VBN cord-328753-qwdxgk4z 49 11 for for IN cord-328753-qwdxgk4z 49 12 imaging image VBG cord-328753-qwdxgk4z 49 13 [ [ -LRB- cord-328753-qwdxgk4z 49 14 24 24 CD cord-328753-qwdxgk4z 49 15 , , , cord-328753-qwdxgk4z 49 16 26 26 CD cord-328753-qwdxgk4z 49 17 , , , cord-328753-qwdxgk4z 49 18 30 30 CD cord-328753-qwdxgk4z 49 19 ] ] -RRB- cord-328753-qwdxgk4z 49 20 . . . cord-328753-qwdxgk4z 50 1 There there EX cord-328753-qwdxgk4z 50 2 has have VBZ cord-328753-qwdxgk4z 50 3 been be VBN cord-328753-qwdxgk4z 50 4 an an DT cord-328753-qwdxgk4z 50 5 explosion explosion NN cord-328753-qwdxgk4z 50 6 in in IN cord-328753-qwdxgk4z 50 7 the the DT cord-328753-qwdxgk4z 50 8 number number NN cord-328753-qwdxgk4z 50 9 of of IN cord-328753-qwdxgk4z 50 10 publications publication NNS cord-328753-qwdxgk4z 50 11 concerning concern VBG cord-328753-qwdxgk4z 50 12 applications application NNS cord-328753-qwdxgk4z 50 13 of of IN cord-328753-qwdxgk4z 50 14 VHHs vhh NNS cord-328753-qwdxgk4z 50 15 that that WDT cord-328753-qwdxgk4z 50 16 cover cover VBP cord-328753-qwdxgk4z 50 17 their -PRON- PRP$ cord-328753-qwdxgk4z 50 18 use use NN cord-328753-qwdxgk4z 50 19 in in IN cord-328753-qwdxgk4z 50 20 pharmaceutical pharmaceutical JJ cord-328753-qwdxgk4z 50 21 development development NN cord-328753-qwdxgk4z 50 22 or or CC cord-328753-qwdxgk4z 50 23 as as IN cord-328753-qwdxgk4z 50 24 biotechnological biotechnological JJ cord-328753-qwdxgk4z 50 25 tools tool NNS cord-328753-qwdxgk4z 50 26 [ [ -LRB- cord-328753-qwdxgk4z 50 27 26 26 CD cord-328753-qwdxgk4z 50 28 , , , cord-328753-qwdxgk4z 50 29 [ [ -LRB- cord-328753-qwdxgk4z 50 30 31 31 CD cord-328753-qwdxgk4z 50 31 ] ] -RRB- cord-328753-qwdxgk4z 51 1 [ [ -LRB- cord-328753-qwdxgk4z 51 2 32 32 CD cord-328753-qwdxgk4z 51 3 ] ] -RRB- cord-328753-qwdxgk4z 51 4 [ [ -LRB- cord-328753-qwdxgk4z 51 5 33 33 CD cord-328753-qwdxgk4z 51 6 ] ] -RRB- cord-328753-qwdxgk4z 51 7 [ [ -LRB- cord-328753-qwdxgk4z 51 8 34 34 CD cord-328753-qwdxgk4z 51 9 ] ] -RRB- cord-328753-qwdxgk4z 51 10 [ [ -LRB- cord-328753-qwdxgk4z 51 11 35 35 CD cord-328753-qwdxgk4z 51 12 ] ] -RRB- cord-328753-qwdxgk4z 51 13 . . . cord-328753-qwdxgk4z 52 1 Here here RB cord-328753-qwdxgk4z 52 2 , , , cord-328753-qwdxgk4z 52 3 we -PRON- PRP cord-328753-qwdxgk4z 52 4 mainly mainly RB cord-328753-qwdxgk4z 52 5 focus focus VBP cord-328753-qwdxgk4z 52 6 on on IN cord-328753-qwdxgk4z 52 7 the the DT cord-328753-qwdxgk4z 52 8 potential potential JJ cord-328753-qwdxgk4z 52 9 use use NN cord-328753-qwdxgk4z 52 10 of of IN cord-328753-qwdxgk4z 52 11 VHHs vhh NNS cord-328753-qwdxgk4z 52 12 for for IN cord-328753-qwdxgk4z 52 13 the the DT cord-328753-qwdxgk4z 52 14 diagnosis diagnosis NN cord-328753-qwdxgk4z 52 15 and and CC cord-328753-qwdxgk4z 52 16 the the DT cord-328753-qwdxgk4z 52 17 treatment treatment NN cord-328753-qwdxgk4z 52 18 of of IN cord-328753-qwdxgk4z 52 19 zoonotic zoonotic JJ cord-328753-qwdxgk4z 52 20 diseases disease NNS cord-328753-qwdxgk4z 52 21 . . . cord-328753-qwdxgk4z 53 1 Zoonotic zoonotic JJ cord-328753-qwdxgk4z 53 2 diseases disease NNS cord-328753-qwdxgk4z 53 3 ( ( -LRB- cord-328753-qwdxgk4z 53 4 ZDs zd NNS cord-328753-qwdxgk4z 53 5 ) ) -RRB- cord-328753-qwdxgk4z 53 6 are be VBP cord-328753-qwdxgk4z 53 7 infections infection NNS cord-328753-qwdxgk4z 53 8 that that WDT cord-328753-qwdxgk4z 53 9 can can MD cord-328753-qwdxgk4z 53 10 be be VB cord-328753-qwdxgk4z 53 11 naturally naturally RB cord-328753-qwdxgk4z 53 12 spread spread VBN cord-328753-qwdxgk4z 53 13 between between IN cord-328753-qwdxgk4z 53 14 vertebrate vertebrate JJ cord-328753-qwdxgk4z 53 15 animals animal NNS cord-328753-qwdxgk4z 53 16 and and CC cord-328753-qwdxgk4z 53 17 humans human NNS cord-328753-qwdxgk4z 53 18 . . . cord-328753-qwdxgk4z 54 1 Several several JJ cord-328753-qwdxgk4z 54 2 recent recent JJ cord-328753-qwdxgk4z 54 3 outbreaks outbreak NNS cord-328753-qwdxgk4z 54 4 , , , cord-328753-qwdxgk4z 54 5 such such JJ cord-328753-qwdxgk4z 54 6 as as IN cord-328753-qwdxgk4z 54 7 Ebola Ebola NNP cord-328753-qwdxgk4z 54 8 and and CC cord-328753-qwdxgk4z 54 9 Zika Zika NNP cord-328753-qwdxgk4z 54 10 have have VBP cord-328753-qwdxgk4z 54 11 emphasized emphasize VBN cord-328753-qwdxgk4z 54 12 the the DT cord-328753-qwdxgk4z 54 13 serious serious JJ cord-328753-qwdxgk4z 54 14 impact impact NN cord-328753-qwdxgk4z 54 15 of of IN cord-328753-qwdxgk4z 54 16 these these DT cord-328753-qwdxgk4z 54 17 diseases disease NNS cord-328753-qwdxgk4z 54 18 on on IN cord-328753-qwdxgk4z 54 19 human human JJ cord-328753-qwdxgk4z 54 20 health health NN cord-328753-qwdxgk4z 54 21 [ [ -LRB- cord-328753-qwdxgk4z 54 22 36 36 CD cord-328753-qwdxgk4z 54 23 ] ] -RRB- cord-328753-qwdxgk4z 54 24 . . . cord-328753-qwdxgk4z 55 1 Their -PRON- PRP$ cord-328753-qwdxgk4z 55 2 expansion expansion NN cord-328753-qwdxgk4z 55 3 is be VBZ cord-328753-qwdxgk4z 55 4 related relate VBN cord-328753-qwdxgk4z 55 5 to to IN cord-328753-qwdxgk4z 55 6 global global JJ cord-328753-qwdxgk4z 55 7 trade trade NN cord-328753-qwdxgk4z 55 8 , , , cord-328753-qwdxgk4z 55 9 human human JJ cord-328753-qwdxgk4z 55 10 migration migration NN cord-328753-qwdxgk4z 55 11 , , , cord-328753-qwdxgk4z 55 12 and and CC cord-328753-qwdxgk4z 55 13 climate climate NN cord-328753-qwdxgk4z 55 14 change change NN cord-328753-qwdxgk4z 55 15 . . . cord-328753-qwdxgk4z 56 1 Up up IN cord-328753-qwdxgk4z 56 2 to to IN cord-328753-qwdxgk4z 56 3 now now RB cord-328753-qwdxgk4z 56 4 , , , cord-328753-qwdxgk4z 56 5 the the DT cord-328753-qwdxgk4z 56 6 outbreaks outbreak NNS cord-328753-qwdxgk4z 56 7 have have VBP cord-328753-qwdxgk4z 56 8 been be VBN cord-328753-qwdxgk4z 56 9 contained contain VBN cord-328753-qwdxgk4z 56 10 by by IN cord-328753-qwdxgk4z 56 11 the the DT cord-328753-qwdxgk4z 56 12 control control NN cord-328753-qwdxgk4z 56 13 of of IN cord-328753-qwdxgk4z 56 14 human human JJ cord-328753-qwdxgk4z 56 15 populations population NNS cord-328753-qwdxgk4z 56 16 in in IN cord-328753-qwdxgk4z 56 17 the the DT cord-328753-qwdxgk4z 56 18 affected affected JJ cord-328753-qwdxgk4z 56 19 areas area NNS cord-328753-qwdxgk4z 56 20 , , , cord-328753-qwdxgk4z 56 21 the the DT cord-328753-qwdxgk4z 56 22 use use NN cord-328753-qwdxgk4z 56 23 of of IN cord-328753-qwdxgk4z 56 24 antibiotics antibiotic NNS cord-328753-qwdxgk4z 56 25 , , , cord-328753-qwdxgk4z 56 26 and and CC cord-328753-qwdxgk4z 56 27 the the DT cord-328753-qwdxgk4z 56 28 development development NN cord-328753-qwdxgk4z 56 29 of of IN cord-328753-qwdxgk4z 56 30 rapid rapid JJ cord-328753-qwdxgk4z 56 31 diagnostic diagnostic JJ cord-328753-qwdxgk4z 56 32 tests test NNS cord-328753-qwdxgk4z 56 33 . . . cord-328753-qwdxgk4z 57 1 However however RB cord-328753-qwdxgk4z 57 2 , , , cord-328753-qwdxgk4z 57 3 the the DT cord-328753-qwdxgk4z 57 4 emergence emergence NN cord-328753-qwdxgk4z 57 5 of of IN cord-328753-qwdxgk4z 57 6 ZDs ZDs NNP cord-328753-qwdxgk4z 57 7 is be VBZ cord-328753-qwdxgk4z 57 8 still still RB cord-328753-qwdxgk4z 57 9 a a DT cord-328753-qwdxgk4z 57 10 major major JJ cord-328753-qwdxgk4z 57 11 challenge challenge NN cord-328753-qwdxgk4z 57 12 and and CC cord-328753-qwdxgk4z 57 13 there there EX cord-328753-qwdxgk4z 57 14 is be VBZ cord-328753-qwdxgk4z 57 15 a a DT cord-328753-qwdxgk4z 57 16 crucial crucial JJ cord-328753-qwdxgk4z 57 17 need need NN cord-328753-qwdxgk4z 57 18 for for IN cord-328753-qwdxgk4z 57 19 new new JJ cord-328753-qwdxgk4z 57 20 tools tool NNS cord-328753-qwdxgk4z 57 21 for for IN cord-328753-qwdxgk4z 57 22 diagnosis diagnosis NN cord-328753-qwdxgk4z 57 23 and and CC cord-328753-qwdxgk4z 57 24 therapy therapy NN cord-328753-qwdxgk4z 57 25 . . . cord-328753-qwdxgk4z 58 1 Camelid Camelid NNP cord-328753-qwdxgk4z 58 2 VHHs vhh NNS cord-328753-qwdxgk4z 58 3 could could MD cord-328753-qwdxgk4z 58 4 offer offer VB cord-328753-qwdxgk4z 58 5 an an DT cord-328753-qwdxgk4z 58 6 attractive attractive JJ cord-328753-qwdxgk4z 58 7 possibility possibility NN cord-328753-qwdxgk4z 58 8 for for IN cord-328753-qwdxgk4z 58 9 the the DT cord-328753-qwdxgk4z 58 10 development development NN cord-328753-qwdxgk4z 58 11 of of IN cord-328753-qwdxgk4z 58 12 such such JJ cord-328753-qwdxgk4z 58 13 tools tool NNS cord-328753-qwdxgk4z 58 14 in in IN cord-328753-qwdxgk4z 58 15 the the DT cord-328753-qwdxgk4z 58 16 future future NN cord-328753-qwdxgk4z 58 17 . . . cord-328753-qwdxgk4z 59 1 Campylobacteriosis Campylobacteriosis NNP cord-328753-qwdxgk4z 59 2 is be VBZ cord-328753-qwdxgk4z 59 3 caused cause VBN cord-328753-qwdxgk4z 59 4 mostly mostly RB cord-328753-qwdxgk4z 59 5 by by IN cord-328753-qwdxgk4z 59 6 Campylobacter Campylobacter NNP cord-328753-qwdxgk4z 59 7 jejuni jejuni NNP cord-328753-qwdxgk4z 59 8 or or CC cord-328753-qwdxgk4z 59 9 Campylobacter Campylobacter NNP cord-328753-qwdxgk4z 59 10 coli coli NNS cord-328753-qwdxgk4z 59 11 . . . cord-328753-qwdxgk4z 60 1 Poultry poultry NN cord-328753-qwdxgk4z 60 2 are be VBP cord-328753-qwdxgk4z 60 3 naturally naturally RB cord-328753-qwdxgk4z 60 4 infected infect VBN cord-328753-qwdxgk4z 60 5 , , , cord-328753-qwdxgk4z 60 6 without without IN cord-328753-qwdxgk4z 60 7 clinical clinical JJ cord-328753-qwdxgk4z 60 8 signs sign NNS cord-328753-qwdxgk4z 60 9 , , , cord-328753-qwdxgk4z 60 10 and and CC cord-328753-qwdxgk4z 60 11 it -PRON- PRP cord-328753-qwdxgk4z 60 12 is be VBZ cord-328753-qwdxgk4z 60 13 the the DT cord-328753-qwdxgk4z 60 14 leading leading JJ cord-328753-qwdxgk4z 60 15 cause cause NN cord-328753-qwdxgk4z 60 16 of of IN cord-328753-qwdxgk4z 60 17 foodborne foodborne JJ cord-328753-qwdxgk4z 60 18 gastroenteritis gastroenteritis NN cord-328753-qwdxgk4z 60 19 in in IN cord-328753-qwdxgk4z 60 20 humans human NNS cord-328753-qwdxgk4z 60 21 worldwide worldwide RB cord-328753-qwdxgk4z 60 22 [ [ -LRB- cord-328753-qwdxgk4z 60 23 37 37 CD cord-328753-qwdxgk4z 60 24 ] ] -RRB- cord-328753-qwdxgk4z 60 25 . . . cord-328753-qwdxgk4z 61 1 A a DT cord-328753-qwdxgk4z 61 2 VHH vhh NN cord-328753-qwdxgk4z 61 3 that that WDT cord-328753-qwdxgk4z 61 4 binds bind VBZ cord-328753-qwdxgk4z 61 5 C. C. NNP cord-328753-qwdxgk4z 61 6 jejuni jejuni NNP cord-328753-qwdxgk4z 61 7 flagella flagellum NNS cord-328753-qwdxgk4z 61 8 was be VBD cord-328753-qwdxgk4z 61 9 isolated isolate VBN cord-328753-qwdxgk4z 61 10 by by IN cord-328753-qwdxgk4z 61 11 Riazi Riazi NNP cord-328753-qwdxgk4z 61 12 et et NNP cord-328753-qwdxgk4z 61 13 al al NNP cord-328753-qwdxgk4z 61 14 . . . cord-328753-qwdxgk4z 62 1 [ [ -LRB- cord-328753-qwdxgk4z 62 2 38 38 CD cord-328753-qwdxgk4z 62 3 ] ] -RRB- cord-328753-qwdxgk4z 62 4 and and CC cord-328753-qwdxgk4z 62 5 engineered engineer VBN cord-328753-qwdxgk4z 62 6 for for IN cord-328753-qwdxgk4z 62 7 greater great JJR cord-328753-qwdxgk4z 62 8 thermal thermal JJ cord-328753-qwdxgk4z 62 9 and and CC cord-328753-qwdxgk4z 62 10 proteolytic proteolytic JJ cord-328753-qwdxgk4z 62 11 stability stability NN cord-328753-qwdxgk4z 62 12 . . . cord-328753-qwdxgk4z 63 1 Hussack Hussack NNP cord-328753-qwdxgk4z 63 2 et et NNP cord-328753-qwdxgk4z 63 3 al al NNP cord-328753-qwdxgk4z 63 4 . . . cord-328753-qwdxgk4z 64 1 [ [ -LRB- cord-328753-qwdxgk4z 64 2 39 39 CD cord-328753-qwdxgk4z 64 3 ] ] -RRB- cord-328753-qwdxgk4z 64 4 obtained obtain VBD cord-328753-qwdxgk4z 64 5 a a DT cord-328753-qwdxgk4z 64 6 highly highly RB cord-328753-qwdxgk4z 64 7 stable stable JJ cord-328753-qwdxgk4z 64 8 VHH vhh NN cord-328753-qwdxgk4z 64 9 through through IN cord-328753-qwdxgk4z 64 10 the the DT cord-328753-qwdxgk4z 64 11 use use NN cord-328753-qwdxgk4z 64 12 of of IN cord-328753-qwdxgk4z 64 13 error error NN cord-328753-qwdxgk4z 64 14 - - HYPH cord-328753-qwdxgk4z 64 15 prone prone JJ cord-328753-qwdxgk4z 64 16 polymerase polymerase NN cord-328753-qwdxgk4z 64 17 chain chain NN cord-328753-qwdxgk4z 64 18 reaction reaction NN cord-328753-qwdxgk4z 64 19 and and CC cord-328753-qwdxgk4z 64 20 disulfide disulfide NN cord-328753-qwdxgk4z 64 21 - - HYPH cord-328753-qwdxgk4z 64 22 bond bond NN cord-328753-qwdxgk4z 64 23 engineering engineering NN cord-328753-qwdxgk4z 64 24 . . . cord-328753-qwdxgk4z 65 1 This this DT cord-328753-qwdxgk4z 65 2 VHH vhh NN cord-328753-qwdxgk4z 65 3 , , , cord-328753-qwdxgk4z 65 4 directed direct VBN cord-328753-qwdxgk4z 65 5 against against IN cord-328753-qwdxgk4z 65 6 the the DT cord-328753-qwdxgk4z 65 7 flagella flagellum NNS cord-328753-qwdxgk4z 65 8 , , , cord-328753-qwdxgk4z 65 9 can can MD cord-328753-qwdxgk4z 65 10 potently potently RB cord-328753-qwdxgk4z 65 11 inhibit inhibit VB cord-328753-qwdxgk4z 65 12 C. C. NNP cord-328753-qwdxgk4z 65 13 jejuni jejuni JJ cord-328753-qwdxgk4z 65 14 motility motility NN cord-328753-qwdxgk4z 65 15 and and CC cord-328753-qwdxgk4z 65 16 is be VBZ cord-328753-qwdxgk4z 65 17 being be VBG cord-328753-qwdxgk4z 65 18 studied study VBN cord-328753-qwdxgk4z 65 19 for for IN cord-328753-qwdxgk4z 65 20 the the DT cord-328753-qwdxgk4z 65 21 prevention prevention NN cord-328753-qwdxgk4z 65 22 or or CC cord-328753-qwdxgk4z 65 23 significant significant JJ cord-328753-qwdxgk4z 65 24 reduction reduction NN cord-328753-qwdxgk4z 65 25 of of IN cord-328753-qwdxgk4z 65 26 C. C. NNP cord-328753-qwdxgk4z 65 27 jejuni jejuni NNP cord-328753-qwdxgk4z 65 28 colonization colonization NN cord-328753-qwdxgk4z 65 29 in in IN cord-328753-qwdxgk4z 65 30 the the DT cord-328753-qwdxgk4z 65 31 gastrointestinal gastrointestinal JJ cord-328753-qwdxgk4z 65 32 tract tract NN cord-328753-qwdxgk4z 65 33 of of IN cord-328753-qwdxgk4z 65 34 chickens chicken NNS cord-328753-qwdxgk4z 65 35 . . . cord-328753-qwdxgk4z 66 1 Recently recently RB cord-328753-qwdxgk4z 66 2 Vanmarsenille Vanmarsenille NNP cord-328753-qwdxgk4z 66 3 et et NNP cord-328753-qwdxgk4z 66 4 al al NNP cord-328753-qwdxgk4z 66 5 [ [ -LRB- cord-328753-qwdxgk4z 66 6 40 40 CD cord-328753-qwdxgk4z 66 7 ] ] -RRB- cord-328753-qwdxgk4z 66 8 described describe VBD cord-328753-qwdxgk4z 66 9 the the DT cord-328753-qwdxgk4z 66 10 isolation isolation NN cord-328753-qwdxgk4z 66 11 and and CC cord-328753-qwdxgk4z 66 12 characterization characterization NN cord-328753-qwdxgk4z 66 13 of of IN cord-328753-qwdxgk4z 66 14 6 6 CD cord-328753-qwdxgk4z 66 15 VHHs vhh NNS cord-328753-qwdxgk4z 66 16 against against IN cord-328753-qwdxgk4z 66 17 multiple multiple JJ cord-328753-qwdxgk4z 66 18 Campylobacter Campylobacter NNP cord-328753-qwdxgk4z 66 19 strains strain NNS cord-328753-qwdxgk4z 66 20 . . . cord-328753-qwdxgk4z 67 1 These these DT cord-328753-qwdxgk4z 67 2 VHHs vhh NNS cord-328753-qwdxgk4z 67 3 which which WDT cord-328753-qwdxgk4z 67 4 bind bind VBP cord-328753-qwdxgk4z 67 5 with with IN cord-328753-qwdxgk4z 67 6 the the DT cord-328753-qwdxgk4z 67 7 major major JJ cord-328753-qwdxgk4z 67 8 outer outer JJ cord-328753-qwdxgk4z 67 9 membrane membrane NN cord-328753-qwdxgk4z 67 10 protein protein NN cord-328753-qwdxgk4z 67 11 ( ( -LRB- cord-328753-qwdxgk4z 67 12 MOMP MOMP NNP cord-328753-qwdxgk4z 67 13 ) ) -RRB- cord-328753-qwdxgk4z 67 14 interacted interact VBD cord-328753-qwdxgk4z 67 15 with with IN cord-328753-qwdxgk4z 67 16 23 23 CD cord-328753-qwdxgk4z 67 17 C. C. NNP cord-328753-qwdxgk4z 67 18 jejuni jejuni NNP cord-328753-qwdxgk4z 67 19 isolates isolate VBZ cord-328753-qwdxgk4z 67 20 and and CC cord-328753-qwdxgk4z 67 21 5 5 CD cord-328753-qwdxgk4z 67 22 C. C. NNP cord-328753-qwdxgk4z 67 23 coli coli NNS cord-328753-qwdxgk4z 67 24 isolates isolate NNS cord-328753-qwdxgk4z 67 25 . . . cord-328753-qwdxgk4z 68 1 They -PRON- PRP cord-328753-qwdxgk4z 68 2 could could MD cord-328753-qwdxgk4z 68 3 potentially potentially RB cord-328753-qwdxgk4z 68 4 be be VB cord-328753-qwdxgk4z 68 5 used use VBN cord-328753-qwdxgk4z 68 6 in in IN cord-328753-qwdxgk4z 68 7 therapy therapy NN cord-328753-qwdxgk4z 68 8 and and CC cord-328753-qwdxgk4z 68 9 as as IN cord-328753-qwdxgk4z 68 10 a a DT cord-328753-qwdxgk4z 68 11 diagnostic diagnostic JJ cord-328753-qwdxgk4z 68 12 tool tool NN cord-328753-qwdxgk4z 68 13 . . . cord-328753-qwdxgk4z 69 1 Escherichia escherichia NN cord-328753-qwdxgk4z 69 2 coli coli NNS cord-328753-qwdxgk4z 69 3 is be VBZ cord-328753-qwdxgk4z 69 4 a a DT cord-328753-qwdxgk4z 69 5 facultative facultative JJ cord-328753-qwdxgk4z 69 6 gram gram NN cord-328753-qwdxgk4z 69 7 - - HYPH cord-328753-qwdxgk4z 69 8 negative negative JJ cord-328753-qwdxgk4z 69 9 bacterium bacterium NN cord-328753-qwdxgk4z 69 10 that that WDT cord-328753-qwdxgk4z 69 11 belongs belong VBZ cord-328753-qwdxgk4z 69 12 to to IN cord-328753-qwdxgk4z 69 13 the the DT cord-328753-qwdxgk4z 69 14 family family NN cord-328753-qwdxgk4z 69 15 Enterobacteriaceae Enterobacteriaceae NNP cord-328753-qwdxgk4z 69 16 . . . cord-328753-qwdxgk4z 70 1 Although although IN cord-328753-qwdxgk4z 70 2 it -PRON- PRP cord-328753-qwdxgk4z 70 3 is be VBZ cord-328753-qwdxgk4z 70 4 normally normally RB cord-328753-qwdxgk4z 70 5 commensal commensal JJ cord-328753-qwdxgk4z 70 6 in in IN cord-328753-qwdxgk4z 70 7 nature nature NN cord-328753-qwdxgk4z 70 8 and and CC cord-328753-qwdxgk4z 70 9 animals animal NNS cord-328753-qwdxgk4z 70 10 , , , cord-328753-qwdxgk4z 70 11 many many JJ cord-328753-qwdxgk4z 70 12 strains strain NNS cord-328753-qwdxgk4z 70 13 are be VBP cord-328753-qwdxgk4z 70 14 food food NN cord-328753-qwdxgk4z 70 15 and and CC cord-328753-qwdxgk4z 70 16 waterborne waterborne JJ cord-328753-qwdxgk4z 70 17 zoonotic zoonotic JJ cord-328753-qwdxgk4z 70 18 pathogens pathogen NNS cord-328753-qwdxgk4z 70 19 . . . cord-328753-qwdxgk4z 71 1 Shiga Shiga NNP cord-328753-qwdxgk4z 71 2 toxin toxin NN cord-328753-qwdxgk4z 72 1 ( ( -LRB- cord-328753-qwdxgk4z 72 2 Stx)-producing stx)-produce VBG cord-328753-qwdxgk4z 72 3 E. E. NNP cord-328753-qwdxgk4z 72 4 coli coli NNS cord-328753-qwdxgk4z 72 5 ( ( -LRB- cord-328753-qwdxgk4z 72 6 STEC STEC NNP cord-328753-qwdxgk4z 72 7 ) ) -RRB- cord-328753-qwdxgk4z 72 8 bacteria bacteria NNS cord-328753-qwdxgk4z 72 9 ( ( -LRB- cord-328753-qwdxgk4z 72 10 which which WDT cord-328753-qwdxgk4z 72 11 include include VBP cord-328753-qwdxgk4z 72 12 enterohemorrhagic enterohemorrhagic NNP cord-328753-qwdxgk4z 72 13 E. E. NNP cord-328753-qwdxgk4z 72 14 coli coli NNS cord-328753-qwdxgk4z 72 15 [ [ -LRB- cord-328753-qwdxgk4z 72 16 EHEC EHEC NNP cord-328753-qwdxgk4z 72 17 ] ] -RRB- cord-328753-qwdxgk4z 72 18 ) ) -RRB- cord-328753-qwdxgk4z 73 1 cause cause VB cord-328753-qwdxgk4z 73 2 no no DT cord-328753-qwdxgk4z 73 3 discernible discernible JJ cord-328753-qwdxgk4z 73 4 disease disease NN cord-328753-qwdxgk4z 73 5 in in IN cord-328753-qwdxgk4z 73 6 their -PRON- PRP$ cord-328753-qwdxgk4z 73 7 animal animal NN cord-328753-qwdxgk4z 73 8 reservoirs reservoir NNS cord-328753-qwdxgk4z 73 9 ; ; : cord-328753-qwdxgk4z 73 10 however however RB cord-328753-qwdxgk4z 73 11 , , , cord-328753-qwdxgk4z 73 12 diarrhea diarrhea NN cord-328753-qwdxgk4z 73 13 , , , cord-328753-qwdxgk4z 73 14 hemorrhagic hemorrhagic JJ cord-328753-qwdxgk4z 73 15 colitis colitis NN cord-328753-qwdxgk4z 73 16 , , , cord-328753-qwdxgk4z 73 17 and and CC cord-328753-qwdxgk4z 73 18 hemolytic hemolytic JJ cord-328753-qwdxgk4z 73 19 uremic uremic JJ cord-328753-qwdxgk4z 73 20 syndrome syndrome NN cord-328753-qwdxgk4z 73 21 ( ( -LRB- cord-328753-qwdxgk4z 73 22 HUS HUS NNP cord-328753-qwdxgk4z 73 23 ) ) -RRB- cord-328753-qwdxgk4z 73 24 are be VBP cord-328753-qwdxgk4z 73 25 common common JJ cord-328753-qwdxgk4z 73 26 in in IN cord-328753-qwdxgk4z 73 27 humans human NNS cord-328753-qwdxgk4z 73 28 [ [ -LRB- cord-328753-qwdxgk4z 73 29 41 41 CD cord-328753-qwdxgk4z 73 30 ] ] -RRB- cord-328753-qwdxgk4z 73 31 . . . cord-328753-qwdxgk4z 74 1 The the DT cord-328753-qwdxgk4z 74 2 major major JJ cord-328753-qwdxgk4z 74 3 virulence virulence NN cord-328753-qwdxgk4z 74 4 determinants determinant NNS cord-328753-qwdxgk4z 74 5 of of IN cord-328753-qwdxgk4z 74 6 STEC STEC NNP cord-328753-qwdxgk4z 74 7 are be VBP cord-328753-qwdxgk4z 74 8 mainly mainly RB cord-328753-qwdxgk4z 74 9 caused cause VBN cord-328753-qwdxgk4z 74 10 by by IN cord-328753-qwdxgk4z 74 11 the the DT cord-328753-qwdxgk4z 74 12 Shiga Shiga NNP cord-328753-qwdxgk4z 74 13 toxins toxin NNS cord-328753-qwdxgk4z 74 14 Stx1 Stx1 NNP cord-328753-qwdxgk4z 74 15 and and CC cord-328753-qwdxgk4z 74 16 Stx2 Stx2 NNP cord-328753-qwdxgk4z 74 17 [ [ -LRB- cord-328753-qwdxgk4z 74 18 42 42 CD cord-328753-qwdxgk4z 74 19 ] ] -RRB- cord-328753-qwdxgk4z 74 20 . . . cord-328753-qwdxgk4z 75 1 VHHs vhh NNS cord-328753-qwdxgk4z 75 2 that that WDT cord-328753-qwdxgk4z 75 3 neutralize neutralize VBP cord-328753-qwdxgk4z 75 4 Stx1 Stx1 NNP cord-328753-qwdxgk4z 75 5 and/or and/or CC cord-328753-qwdxgk4z 75 6 Stx2 Stx2 NNP cord-328753-qwdxgk4z 75 7 have have VBP cord-328753-qwdxgk4z 75 8 recently recently RB cord-328753-qwdxgk4z 75 9 been be VBN cord-328753-qwdxgk4z 75 10 obtained obtain VBN cord-328753-qwdxgk4z 75 11 [ [ -LRB- cord-328753-qwdxgk4z 75 12 43 43 CD cord-328753-qwdxgk4z 75 13 ] ] -RRB- cord-328753-qwdxgk4z 75 14 [ [ -LRB- cord-328753-qwdxgk4z 75 15 44 44 CD cord-328753-qwdxgk4z 75 16 ] ] -RRB- cord-328753-qwdxgk4z 75 17 [ [ -LRB- cord-328753-qwdxgk4z 75 18 45 45 CD cord-328753-qwdxgk4z 75 19 ] ] -RRB- cord-328753-qwdxgk4z 75 20 . . . cord-328753-qwdxgk4z 76 1 The the DT cord-328753-qwdxgk4z 76 2 VHH VHH NNP cord-328753-qwdxgk4z 76 3 2vb27 2vb27 CD cord-328753-qwdxgk4z 76 4 specific specific NN cord-328753-qwdxgk4z 76 5 of of IN cord-328753-qwdxgk4z 76 6 Stx2 Stx2 NNP cord-328753-qwdxgk4z 76 7 was be VBD cord-328753-qwdxgk4z 76 8 unable unable JJ cord-328753-qwdxgk4z 76 9 to to TO cord-328753-qwdxgk4z 76 10 give give VB cord-328753-qwdxgk4z 76 11 protection protection NN cord-328753-qwdxgk4z 76 12 against against IN cord-328753-qwdxgk4z 76 13 a a DT cord-328753-qwdxgk4z 76 14 lethal lethal JJ cord-328753-qwdxgk4z 76 15 dose dose NN cord-328753-qwdxgk4z 76 16 of of IN cord-328753-qwdxgk4z 76 17 toxin toxin NN cord-328753-qwdxgk4z 76 18 in in IN cord-328753-qwdxgk4z 76 19 mice mouse NNS cord-328753-qwdxgk4z 76 20 while while IN cord-328753-qwdxgk4z 76 21 a a DT cord-328753-qwdxgk4z 76 22 trivalent trivalent JJ cord-328753-qwdxgk4z 76 23 molecule molecule NN cord-328753-qwdxgk4z 76 24 ( ( -LRB- cord-328753-qwdxgk4z 76 25 two two CD cord-328753-qwdxgk4z 76 26 copies copy NNS cord-328753-qwdxgk4z 76 27 of of IN cord-328753-qwdxgk4z 76 28 VHH VHH NNP cord-328753-qwdxgk4z 76 29 2vb27 2vb27 CD cord-328753-qwdxgk4z 76 30 and and CC cord-328753-qwdxgk4z 76 31 one one CD cord-328753-qwdxgk4z 76 32 copy copy NN cord-328753-qwdxgk4z 76 33 of of IN cord-328753-qwdxgk4z 76 34 anti anti JJ cord-328753-qwdxgk4z 76 35 - - JJ cord-328753-qwdxgk4z 76 36 albumin albumin JJ cord-328753-qwdxgk4z 76 37 VHH vhh NN cord-328753-qwdxgk4z 76 38 ) ) -RRB- cord-328753-qwdxgk4z 76 39 presented present VBD cord-328753-qwdxgk4z 76 40 an an DT cord-328753-qwdxgk4z 76 41 extended extended JJ cord-328753-qwdxgk4z 76 42 half half JJ cord-328753-qwdxgk4z 76 43 - - HYPH cord-328753-qwdxgk4z 76 44 life life NN cord-328753-qwdxgk4z 76 45 and and CC cord-328753-qwdxgk4z 76 46 was be VBD cord-328753-qwdxgk4z 76 47 able able JJ cord-328753-qwdxgk4z 76 48 to to TO cord-328753-qwdxgk4z 76 49 neutralize neutralize VB cord-328753-qwdxgk4z 76 50 the the DT cord-328753-qwdxgk4z 76 51 in in IN cord-328753-qwdxgk4z 76 52 vivo vivo NN cord-328753-qwdxgk4z 76 53 effect effect NN cord-328753-qwdxgk4z 76 54 of of IN cord-328753-qwdxgk4z 76 55 toxins toxin NNS cord-328753-qwdxgk4z 76 56 in in IN cord-328753-qwdxgk4z 76 57 mouse mouse NN cord-328753-qwdxgk4z 76 58 models model NNS cord-328753-qwdxgk4z 76 59 [ [ -LRB- cord-328753-qwdxgk4z 76 60 43 43 CD cord-328753-qwdxgk4z 76 61 ] ] -RRB- cord-328753-qwdxgk4z 76 62 . . . cord-328753-qwdxgk4z 77 1 Tremblay Tremblay NNP cord-328753-qwdxgk4z 77 2 et et NNP cord-328753-qwdxgk4z 77 3 al al NNP cord-328753-qwdxgk4z 77 4 [ [ -LRB- cord-328753-qwdxgk4z 77 5 44 44 CD cord-328753-qwdxgk4z 77 6 ] ] -RRB- cord-328753-qwdxgk4z 77 7 showed show VBD cord-328753-qwdxgk4z 77 8 that that IN cord-328753-qwdxgk4z 77 9 VHH vhh NN cord-328753-qwdxgk4z 77 10 heterodimers heterodimer NNS cord-328753-qwdxgk4z 77 11 , , , cord-328753-qwdxgk4z 77 12 containing contain VBG cord-328753-qwdxgk4z 77 13 two two CD cord-328753-qwdxgk4z 77 14 linked link VBN cord-328753-qwdxgk4z 77 15 neutralizing neutralize VBG cord-328753-qwdxgk4z 77 16 VHHs vhh NNS cord-328753-qwdxgk4z 77 17 , , , cord-328753-qwdxgk4z 77 18 generally generally RB cord-328753-qwdxgk4z 77 19 neutralized neutralize VBN cord-328753-qwdxgk4z 77 20 Stx Stx NNP cord-328753-qwdxgk4z 77 21 much much RB cord-328753-qwdxgk4z 77 22 more more RBR cord-328753-qwdxgk4z 77 23 efficiently efficiently RB cord-328753-qwdxgk4z 77 24 than than IN cord-328753-qwdxgk4z 77 25 a a DT cord-328753-qwdxgk4z 77 26 pool pool NN cord-328753-qwdxgk4z 77 27 of of IN cord-328753-qwdxgk4z 77 28 individual individual JJ cord-328753-qwdxgk4z 77 29 monomers monomer NNS cord-328753-qwdxgk4z 77 30 . . . cord-328753-qwdxgk4z 78 1 Moreover moreover RB cord-328753-qwdxgk4z 78 2 co co NN cord-328753-qwdxgk4z 78 3 - - NN cord-328753-qwdxgk4z 78 4 administration administration NN cord-328753-qwdxgk4z 78 5 of of IN cord-328753-qwdxgk4z 78 6 an an DT cord-328753-qwdxgk4z 78 7 effector effector JJ cord-328753-qwdxgk4z 78 8 Ab Ab NNP cord-328753-qwdxgk4z 78 9 substantially substantially RB cord-328753-qwdxgk4z 78 10 improved improve VBD cord-328753-qwdxgk4z 78 11 the the DT cord-328753-qwdxgk4z 78 12 ability ability NN cord-328753-qwdxgk4z 78 13 of of IN cord-328753-qwdxgk4z 78 14 Stx Stx NNP cord-328753-qwdxgk4z 78 15 toxin toxin NN cord-328753-qwdxgk4z 78 16 - - HYPH cord-328753-qwdxgk4z 78 17 neutralizing neutralize VBG cord-328753-qwdxgk4z 78 18 VHHs vhh NNS cord-328753-qwdxgk4z 78 19 to to TO cord-328753-qwdxgk4z 78 20 prevent prevent VB cord-328753-qwdxgk4z 78 21 death death NN cord-328753-qwdxgk4z 78 22 or or CC cord-328753-qwdxgk4z 78 23 kidney kidney NN cord-328753-qwdxgk4z 78 24 damage damage NN cord-328753-qwdxgk4z 78 25 in in IN cord-328753-qwdxgk4z 78 26 mice mice NN cord-328753-qwdxgk4z 78 27 following follow VBG cord-328753-qwdxgk4z 78 28 challenge challenge NN cord-328753-qwdxgk4z 78 29 with with IN cord-328753-qwdxgk4z 78 30 Stx1 Stx1 NNP cord-328753-qwdxgk4z 78 31 or or CC cord-328753-qwdxgk4z 78 32 Stx2 Stx2 NNP cord-328753-qwdxgk4z 78 33 . . . cord-328753-qwdxgk4z 79 1 Listeriosis Listeriosis NNP cord-328753-qwdxgk4z 79 2 is be VBZ cord-328753-qwdxgk4z 79 3 a a DT cord-328753-qwdxgk4z 79 4 bacterial bacterial JJ cord-328753-qwdxgk4z 79 5 infection infection NN cord-328753-qwdxgk4z 79 6 caused cause VBN cord-328753-qwdxgk4z 79 7 by by IN cord-328753-qwdxgk4z 79 8 the the DT cord-328753-qwdxgk4z 79 9 gram gram NN cord-328753-qwdxgk4z 79 10 - - HYPH cord-328753-qwdxgk4z 79 11 positive positive JJ cord-328753-qwdxgk4z 79 12 bacterium bacterium NN cord-328753-qwdxgk4z 79 13 Listeria Listeria NNP cord-328753-qwdxgk4z 79 14 monocytogenes monocytogene NNS cord-328753-qwdxgk4z 79 15 . . . cord-328753-qwdxgk4z 80 1 The the DT cord-328753-qwdxgk4z 80 2 major major JJ cord-328753-qwdxgk4z 80 3 source source NN cord-328753-qwdxgk4z 80 4 of of IN cord-328753-qwdxgk4z 80 5 infection infection NN cord-328753-qwdxgk4z 80 6 is be VBZ cord-328753-qwdxgk4z 80 7 contaminated contaminate VBN cord-328753-qwdxgk4z 80 8 food food NN cord-328753-qwdxgk4z 80 9 . . . cord-328753-qwdxgk4z 81 1 The the DT cord-328753-qwdxgk4z 81 2 disease disease NN cord-328753-qwdxgk4z 81 3 primarily primarily RB cord-328753-qwdxgk4z 81 4 affects affect VBZ cord-328753-qwdxgk4z 81 5 elderly elderly JJ cord-328753-qwdxgk4z 81 6 people people NNS cord-328753-qwdxgk4z 81 7 , , , cord-328753-qwdxgk4z 81 8 immunocompromised immunocompromised JJ cord-328753-qwdxgk4z 81 9 patients patient NNS cord-328753-qwdxgk4z 81 10 , , , cord-328753-qwdxgk4z 81 11 pregnant pregnant JJ cord-328753-qwdxgk4z 81 12 women woman NNS cord-328753-qwdxgk4z 81 13 , , , cord-328753-qwdxgk4z 81 14 causing cause VBG cord-328753-qwdxgk4z 81 15 abortion abortion NN cord-328753-qwdxgk4z 81 16 , , , cord-328753-qwdxgk4z 81 17 and and CC cord-328753-qwdxgk4z 81 18 newborns newborn NNS cord-328753-qwdxgk4z 81 19 [ [ -LRB- cord-328753-qwdxgk4z 81 20 46 46 CD cord-328753-qwdxgk4z 81 21 ] ] -RRB- cord-328753-qwdxgk4z 81 22 . . . cord-328753-qwdxgk4z 82 1 VHHs VHHs NNP cord-328753-qwdxgk4z 82 2 specific specific JJ cord-328753-qwdxgk4z 82 3 for for IN cord-328753-qwdxgk4z 82 4 the the DT cord-328753-qwdxgk4z 82 5 invasin invasin NNP cord-328753-qwdxgk4z 82 6 , , , cord-328753-qwdxgk4z 82 7 internalin internalin NNP cord-328753-qwdxgk4z 82 8 B B NNP cord-328753-qwdxgk4z 82 9 , , , cord-328753-qwdxgk4z 82 10 of of IN cord-328753-qwdxgk4z 82 11 L. L. NNP cord-328753-qwdxgk4z 82 12 monocytogenes monocytogene NNS cord-328753-qwdxgk4z 82 13 have have VBP cord-328753-qwdxgk4z 82 14 been be VBN cord-328753-qwdxgk4z 82 15 isolated isolate VBN cord-328753-qwdxgk4z 82 16 [ [ -LRB- cord-328753-qwdxgk4z 82 17 47 47 CD cord-328753-qwdxgk4z 82 18 , , , cord-328753-qwdxgk4z 82 19 48 48 CD cord-328753-qwdxgk4z 82 20 ] ] -RRB- cord-328753-qwdxgk4z 82 21 and and CC cord-328753-qwdxgk4z 82 22 can can MD cord-328753-qwdxgk4z 82 23 inhibit inhibit VB cord-328753-qwdxgk4z 82 24 Listeria Listeria NNP cord-328753-qwdxgk4z 82 25 invasion invasion NN cord-328753-qwdxgk4z 82 26 in in IN cord-328753-qwdxgk4z 82 27 vitro vitro FW cord-328753-qwdxgk4z 82 28 . . . cord-328753-qwdxgk4z 83 1 A a DT cord-328753-qwdxgk4z 83 2 crystal crystal NN cord-328753-qwdxgk4z 83 3 structure structure NN cord-328753-qwdxgk4z 83 4 between between IN cord-328753-qwdxgk4z 83 5 one one CD cord-328753-qwdxgk4z 83 6 VHH vhh NN cord-328753-qwdxgk4z 83 7 and and CC cord-328753-qwdxgk4z 83 8 internalin internalin NNP cord-328753-qwdxgk4z 83 9 B B NNP cord-328753-qwdxgk4z 83 10 shows show VBZ cord-328753-qwdxgk4z 83 11 that that IN cord-328753-qwdxgk4z 83 12 the the DT cord-328753-qwdxgk4z 83 13 VHH VHH NNP cord-328753-qwdxgk4z 83 14 competes compete VBZ cord-328753-qwdxgk4z 83 15 with with IN cord-328753-qwdxgk4z 83 16 c c NN cord-328753-qwdxgk4z 83 17 - - HYPH cord-328753-qwdxgk4z 83 18 met meet VBN cord-328753-qwdxgk4z 83 19 , , , cord-328753-qwdxgk4z 83 20 the the DT cord-328753-qwdxgk4z 83 21 target target NN cord-328753-qwdxgk4z 83 22 cell cell NN cord-328753-qwdxgk4z 83 23 receptor receptor NN cord-328753-qwdxgk4z 83 24 of of IN cord-328753-qwdxgk4z 83 25 this this DT cord-328753-qwdxgk4z 83 26 invasin invasin NNP cord-328753-qwdxgk4z 83 27 , , , cord-328753-qwdxgk4z 83 28 explaining explain VBG cord-328753-qwdxgk4z 83 29 the the DT cord-328753-qwdxgk4z 83 30 protective protective JJ cord-328753-qwdxgk4z 83 31 effect effect NN cord-328753-qwdxgk4z 83 32 [ [ -LRB- cord-328753-qwdxgk4z 83 33 48 48 CD cord-328753-qwdxgk4z 83 34 ] ] -RRB- cord-328753-qwdxgk4z 83 35 . . . cord-328753-qwdxgk4z 84 1 Two two CD cord-328753-qwdxgk4z 84 2 VHHs vhh NNS cord-328753-qwdxgk4z 84 3 that that WDT cord-328753-qwdxgk4z 84 4 specifically specifically RB cord-328753-qwdxgk4z 84 5 bind bind VBP cord-328753-qwdxgk4z 84 6 to to IN cord-328753-qwdxgk4z 84 7 three three CD cord-328753-qwdxgk4z 84 8 L. L. NNP cord-328753-qwdxgk4z 84 9 monocytogenes monocytogene NNS cord-328753-qwdxgk4z 84 10 serotypes serotype NNS cord-328753-qwdxgk4z 84 11 ( ( -LRB- cord-328753-qwdxgk4z 84 12 1/2a 1/2a CD cord-328753-qwdxgk4z 84 13 , , , cord-328753-qwdxgk4z 84 14 1/2b 1/2b CD cord-328753-qwdxgk4z 84 15 , , , cord-328753-qwdxgk4z 84 16 and and CC cord-328753-qwdxgk4z 84 17 4b 4b LS cord-328753-qwdxgk4z 84 18 ) ) -RRB- cord-328753-qwdxgk4z 84 19 have have VBP cord-328753-qwdxgk4z 84 20 been be VBN cord-328753-qwdxgk4z 84 21 isolated isolate VBN cord-328753-qwdxgk4z 84 22 from from IN cord-328753-qwdxgk4z 84 23 a a DT cord-328753-qwdxgk4z 84 24 non non JJ cord-328753-qwdxgk4z 84 25 - - JJ cord-328753-qwdxgk4z 84 26 immune immune JJ cord-328753-qwdxgk4z 84 27 library library NN cord-328753-qwdxgk4z 84 28 [ [ -LRB- cord-328753-qwdxgk4z 84 29 49 49 CD cord-328753-qwdxgk4z 84 30 ] ] -RRB- cord-328753-qwdxgk4z 84 31 . . . cord-328753-qwdxgk4z 85 1 A a DT cord-328753-qwdxgk4z 85 2 sandwich sandwich NN cord-328753-qwdxgk4z 85 3 ELISA ELISA NNP cord-328753-qwdxgk4z 85 4 was be VBD cord-328753-qwdxgk4z 85 5 developed develop VBN cord-328753-qwdxgk4z 85 6 using use VBG cord-328753-qwdxgk4z 85 7 a a DT cord-328753-qwdxgk4z 85 8 mAb mab NN cord-328753-qwdxgk4z 85 9 for for IN cord-328753-qwdxgk4z 85 10 antibody antibody NN cord-328753-qwdxgk4z 85 11 capture capture NN cord-328753-qwdxgk4z 85 12 and and CC cord-328753-qwdxgk4z 85 13 one one CD cord-328753-qwdxgk4z 85 14 VHH vhh NN cord-328753-qwdxgk4z 85 15 , , , cord-328753-qwdxgk4z 85 16 L5 l5 NN cord-328753-qwdxgk4z 85 17 - - HYPH cord-328753-qwdxgk4z 85 18 79 79 CD cord-328753-qwdxgk4z 85 19 for for IN cord-328753-qwdxgk4z 85 20 detection detection NN cord-328753-qwdxgk4z 85 21 , , , cord-328753-qwdxgk4z 85 22 with with IN cord-328753-qwdxgk4z 85 23 a a DT cord-328753-qwdxgk4z 85 24 detection detection NN cord-328753-qwdxgk4z 85 25 limit limit NN cord-328753-qwdxgk4z 85 26 of of IN cord-328753-qwdxgk4z 85 27 1 1 CD cord-328753-qwdxgk4z 85 28 × × CD cord-328753-qwdxgk4z 85 29 10 10 CD cord-328753-qwdxgk4z 85 30 4 4 CD cord-328753-qwdxgk4z 85 31 colony colony NN cord-328753-qwdxgk4z 85 32 forming form VBG cord-328753-qwdxgk4z 85 33 units unit NNS cord-328753-qwdxgk4z 85 34 ( ( -LRB- cord-328753-qwdxgk4z 85 35 CFU)/ml CFU)/ml NFP cord-328753-qwdxgk4z 85 36 of of IN cord-328753-qwdxgk4z 85 37 bacteria bacteria NNS cord-328753-qwdxgk4z 85 38 in in IN cord-328753-qwdxgk4z 85 39 milk milk NN cord-328753-qwdxgk4z 85 40 . . . cord-328753-qwdxgk4z 86 1 Bacillus bacillus NN cord-328753-qwdxgk4z 86 2 anthracis anthracis NN cord-328753-qwdxgk4z 86 3 , , , cord-328753-qwdxgk4z 86 4 the the DT cord-328753-qwdxgk4z 86 5 causative causative JJ cord-328753-qwdxgk4z 86 6 organism organism NN cord-328753-qwdxgk4z 86 7 of of IN cord-328753-qwdxgk4z 86 8 anthrax anthrax NN cord-328753-qwdxgk4z 86 9 , , , cord-328753-qwdxgk4z 86 10 is be VBZ cord-328753-qwdxgk4z 86 11 a a DT cord-328753-qwdxgk4z 86 12 sporeforming sporeforme VBG cord-328753-qwdxgk4z 86 13 Gram gram NN cord-328753-qwdxgk4z 86 14 - - HYPH cord-328753-qwdxgk4z 86 15 positive positive JJ cord-328753-qwdxgk4z 86 16 bacillus bacillus NN cord-328753-qwdxgk4z 86 17 commonly commonly RB cord-328753-qwdxgk4z 86 18 found find VBN cord-328753-qwdxgk4z 86 19 in in IN cord-328753-qwdxgk4z 86 20 the the DT cord-328753-qwdxgk4z 86 21 soil soil NN cord-328753-qwdxgk4z 86 22 of of IN cord-328753-qwdxgk4z 86 23 endemic endemic JJ cord-328753-qwdxgk4z 86 24 areas area NNS cord-328753-qwdxgk4z 86 25 . . . cord-328753-qwdxgk4z 87 1 Herbivores herbivore NNS cord-328753-qwdxgk4z 87 2 can can MD cord-328753-qwdxgk4z 87 3 be be VB cord-328753-qwdxgk4z 87 4 infected infect VBN cord-328753-qwdxgk4z 87 5 while while IN cord-328753-qwdxgk4z 87 6 grazing graze VBG cord-328753-qwdxgk4z 87 7 . . . cord-328753-qwdxgk4z 88 1 Recently recently RB cord-328753-qwdxgk4z 88 2 , , , cord-328753-qwdxgk4z 88 3 anthrax anthrax NN cord-328753-qwdxgk4z 88 4 was be VBD cord-328753-qwdxgk4z 88 5 detected detect VBN cord-328753-qwdxgk4z 88 6 in in IN cord-328753-qwdxgk4z 88 7 Siberia Siberia NNP cord-328753-qwdxgk4z 88 8 after after IN cord-328753-qwdxgk4z 88 9 degradation degradation NN cord-328753-qwdxgk4z 88 10 of of IN cord-328753-qwdxgk4z 88 11 the the DT cord-328753-qwdxgk4z 88 12 permafrost permafrost NN cord-328753-qwdxgk4z 88 13 due due IN cord-328753-qwdxgk4z 88 14 to to IN cord-328753-qwdxgk4z 88 15 global global JJ cord-328753-qwdxgk4z 88 16 warming warming NN cord-328753-qwdxgk4z 88 17 [ [ -LRB- cord-328753-qwdxgk4z 88 18 50 50 CD cord-328753-qwdxgk4z 88 19 ] ] -RRB- cord-328753-qwdxgk4z 88 20 . . . cord-328753-qwdxgk4z 89 1 B. B. NNP cord-328753-qwdxgk4z 89 2 anthracis anthracis NN cord-328753-qwdxgk4z 89 3 is be VBZ cord-328753-qwdxgk4z 89 4 also also RB cord-328753-qwdxgk4z 89 5 one one CD cord-328753-qwdxgk4z 89 6 of of IN cord-328753-qwdxgk4z 89 7 the the DT cord-328753-qwdxgk4z 89 8 most most RBS cord-328753-qwdxgk4z 89 9 important important JJ cord-328753-qwdxgk4z 89 10 biological biological JJ cord-328753-qwdxgk4z 89 11 warfare warfare NN cord-328753-qwdxgk4z 89 12 agents agent NNS cord-328753-qwdxgk4z 89 13 , , , cord-328753-qwdxgk4z 89 14 because because IN cord-328753-qwdxgk4z 89 15 of of IN cord-328753-qwdxgk4z 89 16 its -PRON- PRP$ cord-328753-qwdxgk4z 89 17 pathogenic pathogenic JJ cord-328753-qwdxgk4z 89 18 nature nature NN cord-328753-qwdxgk4z 89 19 and and CC cord-328753-qwdxgk4z 89 20 spore spore NN cord-328753-qwdxgk4z 89 21 - - HYPH cord-328753-qwdxgk4z 89 22 forming form VBG cord-328753-qwdxgk4z 89 23 capacity capacity NN cord-328753-qwdxgk4z 89 24 [ [ -LRB- cord-328753-qwdxgk4z 89 25 51 51 CD cord-328753-qwdxgk4z 89 26 ] ] -RRB- cord-328753-qwdxgk4z 89 27 . . . cord-328753-qwdxgk4z 90 1 The the DT cord-328753-qwdxgk4z 90 2 bioterrorist bioterrorist NN cord-328753-qwdxgk4z 90 3 events event NNS cord-328753-qwdxgk4z 90 4 in in IN cord-328753-qwdxgk4z 90 5 the the DT cord-328753-qwdxgk4z 90 6 United United NNP cord-328753-qwdxgk4z 90 7 States States NNP cord-328753-qwdxgk4z 90 8 in in IN cord-328753-qwdxgk4z 90 9 2001 2001 CD cord-328753-qwdxgk4z 90 10 revealed reveal VBD cord-328753-qwdxgk4z 90 11 that that DT cord-328753-qwdxgk4z 90 12 treatment treatment NN cord-328753-qwdxgk4z 90 13 with with IN cord-328753-qwdxgk4z 90 14 antibiotics antibiotic NNS cord-328753-qwdxgk4z 90 15 is be VBZ cord-328753-qwdxgk4z 90 16 not not RB cord-328753-qwdxgk4z 90 17 always always RB cord-328753-qwdxgk4z 90 18 sufficient sufficient JJ cord-328753-qwdxgk4z 90 19 to to TO cord-328753-qwdxgk4z 90 20 prevent prevent VB cord-328753-qwdxgk4z 90 21 patient patient JJ cord-328753-qwdxgk4z 90 22 deaths death NNS cord-328753-qwdxgk4z 90 23 , , , cord-328753-qwdxgk4z 90 24 due due IN cord-328753-qwdxgk4z 90 25 to to IN cord-328753-qwdxgk4z 90 26 the the DT cord-328753-qwdxgk4z 90 27 effects effect NNS cord-328753-qwdxgk4z 90 28 of of IN cord-328753-qwdxgk4z 90 29 toxins toxin NNS cord-328753-qwdxgk4z 90 30 produced produce VBN cord-328753-qwdxgk4z 90 31 by by IN cord-328753-qwdxgk4z 90 32 the the DT cord-328753-qwdxgk4z 90 33 bacteria bacteria NNS cord-328753-qwdxgk4z 90 34 . . . cord-328753-qwdxgk4z 91 1 Neutralizing neutralize VBG cord-328753-qwdxgk4z 91 2 mAbs mAbs NNP cord-328753-qwdxgk4z 91 3 may may MD cord-328753-qwdxgk4z 91 4 therefore therefore RB cord-328753-qwdxgk4z 91 5 be be VB cord-328753-qwdxgk4z 91 6 of of IN cord-328753-qwdxgk4z 91 7 great great JJ cord-328753-qwdxgk4z 91 8 therapeutic therapeutic JJ cord-328753-qwdxgk4z 91 9 value value NN cord-328753-qwdxgk4z 91 10 , , , cord-328753-qwdxgk4z 91 11 complementing complement VBG cord-328753-qwdxgk4z 91 12 antibiotic antibiotic JJ cord-328753-qwdxgk4z 91 13 treatment treatment NN cord-328753-qwdxgk4z 91 14 to to TO cord-328753-qwdxgk4z 91 15 prevent prevent VB cord-328753-qwdxgk4z 91 16 the the DT cord-328753-qwdxgk4z 91 17 toxin toxin NN cord-328753-qwdxgk4z 91 18 - - HYPH cord-328753-qwdxgk4z 91 19 dependent dependent JJ cord-328753-qwdxgk4z 91 20 symptoms symptom NNS cord-328753-qwdxgk4z 91 21 of of IN cord-328753-qwdxgk4z 91 22 anthrax anthrax NN cord-328753-qwdxgk4z 91 23 [ [ -LRB- cord-328753-qwdxgk4z 91 24 52 52 CD cord-328753-qwdxgk4z 91 25 ] ] -RRB- cord-328753-qwdxgk4z 91 26 . . . cord-328753-qwdxgk4z 92 1 Anthrax Anthrax NNP cord-328753-qwdxgk4z 92 2 is be VBZ cord-328753-qwdxgk4z 92 3 caused cause VBN cord-328753-qwdxgk4z 92 4 by by IN cord-328753-qwdxgk4z 92 5 a a DT cord-328753-qwdxgk4z 92 6 toxin toxin NN cord-328753-qwdxgk4z 92 7 consisting consist VBG cord-328753-qwdxgk4z 92 8 of of IN cord-328753-qwdxgk4z 92 9 protective protective JJ cord-328753-qwdxgk4z 92 10 antigen antigen NN cord-328753-qwdxgk4z 92 11 ( ( -LRB- cord-328753-qwdxgk4z 92 12 PA PA NNP cord-328753-qwdxgk4z 92 13 ) ) -RRB- cord-328753-qwdxgk4z 92 14 , , , cord-328753-qwdxgk4z 92 15 lethal lethal JJ cord-328753-qwdxgk4z 92 16 factor factor NN cord-328753-qwdxgk4z 92 17 ( ( -LRB- cord-328753-qwdxgk4z 92 18 LF LF NNP cord-328753-qwdxgk4z 92 19 ) ) -RRB- cord-328753-qwdxgk4z 92 20 , , , cord-328753-qwdxgk4z 92 21 and and CC cord-328753-qwdxgk4z 92 22 edema edema NN cord-328753-qwdxgk4z 92 23 factor factor NN cord-328753-qwdxgk4z 92 24 ( ( -LRB- cord-328753-qwdxgk4z 92 25 EF EF NNP cord-328753-qwdxgk4z 92 26 ) ) -RRB- cord-328753-qwdxgk4z 92 27 . . . cord-328753-qwdxgk4z 93 1 Several several JJ cord-328753-qwdxgk4z 93 2 VHHs vhh NNS cord-328753-qwdxgk4z 93 3 directed direct VBN cord-328753-qwdxgk4z 93 4 against against IN cord-328753-qwdxgk4z 93 5 the the DT cord-328753-qwdxgk4z 93 6 three three CD cord-328753-qwdxgk4z 93 7 components component NNS cord-328753-qwdxgk4z 93 8 of of IN cord-328753-qwdxgk4z 93 9 the the DT cord-328753-qwdxgk4z 93 10 toxin toxin NN cord-328753-qwdxgk4z 93 11 have have VBP cord-328753-qwdxgk4z 93 12 been be VBN cord-328753-qwdxgk4z 93 13 shown show VBN cord-328753-qwdxgk4z 93 14 to to TO cord-328753-qwdxgk4z 93 15 be be VB cord-328753-qwdxgk4z 93 16 efficient efficient JJ cord-328753-qwdxgk4z 93 17 against against IN cord-328753-qwdxgk4z 93 18 Anthrax Anthrax NNP cord-328753-qwdxgk4z 93 19 disease disease NN cord-328753-qwdxgk4z 93 20 [ [ -LRB- cord-328753-qwdxgk4z 93 21 53 53 CD cord-328753-qwdxgk4z 93 22 , , , cord-328753-qwdxgk4z 93 23 54 54 CD cord-328753-qwdxgk4z 93 24 ] ] -RRB- cord-328753-qwdxgk4z 93 25 . . . cord-328753-qwdxgk4z 94 1 Gene gene NN cord-328753-qwdxgk4z 94 2 therapy therapy NN cord-328753-qwdxgk4z 94 3 with with IN cord-328753-qwdxgk4z 94 4 an an DT cord-328753-qwdxgk4z 94 5 adenoviral adenoviral JJ cord-328753-qwdxgk4z 94 6 vector vector NN cord-328753-qwdxgk4z 94 7 expressing express VBG cord-328753-qwdxgk4z 94 8 a a DT cord-328753-qwdxgk4z 94 9 bispecific bispecific NN cord-328753-qwdxgk4z 94 10 VHH vhh NN cord-328753-qwdxgk4z 94 11 , , , cord-328753-qwdxgk4z 94 12 consisting consist VBG cord-328753-qwdxgk4z 94 13 of of IN cord-328753-qwdxgk4z 94 14 two two CD cord-328753-qwdxgk4z 94 15 linked link VBN cord-328753-qwdxgk4z 94 16 VHHs vhh NNS cord-328753-qwdxgk4z 94 17 targeting target VBG cord-328753-qwdxgk4z 94 18 different different JJ cord-328753-qwdxgk4z 94 19 PA PA NNP cord-328753-qwdxgk4z 94 20 - - HYPH cord-328753-qwdxgk4z 94 21 neutralizing neutralize VBG cord-328753-qwdxgk4z 94 22 epitopes epitope NNS cord-328753-qwdxgk4z 94 23 , , , cord-328753-qwdxgk4z 94 24 was be VBD cord-328753-qwdxgk4z 94 25 tested test VBN cord-328753-qwdxgk4z 94 26 in in IN cord-328753-qwdxgk4z 94 27 mice mouse NNS cord-328753-qwdxgk4z 94 28 , , , cord-328753-qwdxgk4z 94 29 and and CC cord-328753-qwdxgk4z 94 30 found find VBD cord-328753-qwdxgk4z 94 31 to to TO cord-328753-qwdxgk4z 94 32 protect protect VB cord-328753-qwdxgk4z 94 33 them -PRON- PRP cord-328753-qwdxgk4z 94 34 from from IN cord-328753-qwdxgk4z 94 35 anthrax anthrax NN cord-328753-qwdxgk4z 94 36 toxin toxin NN cord-328753-qwdxgk4z 94 37 challenge challenge NN cord-328753-qwdxgk4z 94 38 and and CC cord-328753-qwdxgk4z 94 39 anthrax anthrax NN cord-328753-qwdxgk4z 94 40 spore spore NN cord-328753-qwdxgk4z 94 41 infection infection NN cord-328753-qwdxgk4z 94 42 [ [ -LRB- cord-328753-qwdxgk4z 94 43 55 55 CD cord-328753-qwdxgk4z 94 44 ] ] -RRB- cord-328753-qwdxgk4z 94 45 . . . cord-328753-qwdxgk4z 95 1 Taeniasis taeniasis NN cord-328753-qwdxgk4z 95 2 occurs occur VBZ cord-328753-qwdxgk4z 95 3 in in IN cord-328753-qwdxgk4z 95 4 the the DT cord-328753-qwdxgk4z 95 5 human human JJ cord-328753-qwdxgk4z 95 6 host host NN cord-328753-qwdxgk4z 95 7 , , , cord-328753-qwdxgk4z 95 8 after after IN cord-328753-qwdxgk4z 95 9 ingestion ingestion NN cord-328753-qwdxgk4z 95 10 of of IN cord-328753-qwdxgk4z 95 11 undercooked undercooked JJ cord-328753-qwdxgk4z 95 12 pork pork NN cord-328753-qwdxgk4z 95 13 infected infect VBN cord-328753-qwdxgk4z 95 14 with with IN cord-328753-qwdxgk4z 95 15 cysticerci cysticerci NNP cord-328753-qwdxgk4z 95 16 . . . cord-328753-qwdxgk4z 96 1 Cysticercosis Cysticercosis NNP cord-328753-qwdxgk4z 96 2 is be VBZ cord-328753-qwdxgk4z 96 3 caused cause VBN cord-328753-qwdxgk4z 96 4 by by IN cord-328753-qwdxgk4z 96 5 the the DT cord-328753-qwdxgk4z 96 6 larval larval JJ cord-328753-qwdxgk4z 96 7 stage stage NN cord-328753-qwdxgk4z 96 8 of of IN cord-328753-qwdxgk4z 96 9 the the DT cord-328753-qwdxgk4z 96 10 pork pork NN cord-328753-qwdxgk4z 96 11 tapeworm tapeworm NN cord-328753-qwdxgk4z 96 12 Taenia Taenia NNP cord-328753-qwdxgk4z 96 13 solium solium NN cord-328753-qwdxgk4z 96 14 . . . cord-328753-qwdxgk4z 97 1 Humans human NNS cord-328753-qwdxgk4z 97 2 are be VBP cord-328753-qwdxgk4z 97 3 the the DT cord-328753-qwdxgk4z 97 4 definitive definitive JJ cord-328753-qwdxgk4z 97 5 host host NN cord-328753-qwdxgk4z 97 6 , , , cord-328753-qwdxgk4z 97 7 harboring harbor VBG cord-328753-qwdxgk4z 97 8 the the DT cord-328753-qwdxgk4z 97 9 adult adult NN cord-328753-qwdxgk4z 97 10 tapeworm tapeworm NN cord-328753-qwdxgk4z 97 11 in in IN cord-328753-qwdxgk4z 97 12 the the DT cord-328753-qwdxgk4z 97 13 intestine intestine NN cord-328753-qwdxgk4z 97 14 , , , cord-328753-qwdxgk4z 97 15 but but CC cord-328753-qwdxgk4z 97 16 both both DT cord-328753-qwdxgk4z 97 17 pigs pig NNS cord-328753-qwdxgk4z 97 18 and and CC cord-328753-qwdxgk4z 97 19 humans human NNS cord-328753-qwdxgk4z 97 20 can can MD cord-328753-qwdxgk4z 97 21 be be VB cord-328753-qwdxgk4z 97 22 infected infect VBN cord-328753-qwdxgk4z 97 23 with with IN cord-328753-qwdxgk4z 97 24 the the DT cord-328753-qwdxgk4z 97 25 cysticerci cysticerci NNP cord-328753-qwdxgk4z 97 26 [ [ -LRB- cord-328753-qwdxgk4z 97 27 56 56 CD cord-328753-qwdxgk4z 97 28 ] ] -RRB- cord-328753-qwdxgk4z 97 29 . . . cord-328753-qwdxgk4z 98 1 The the DT cord-328753-qwdxgk4z 98 2 mAbs mabs NN cord-328753-qwdxgk4z 98 3 obtained obtain VBN cord-328753-qwdxgk4z 98 4 thus thus RB cord-328753-qwdxgk4z 98 5 far far RB cord-328753-qwdxgk4z 98 6 are be VBP cord-328753-qwdxgk4z 98 7 not not RB cord-328753-qwdxgk4z 98 8 genus genus NN cord-328753-qwdxgk4z 98 9 - - HYPH cord-328753-qwdxgk4z 98 10 specific specific JJ cord-328753-qwdxgk4z 98 11 , , , cord-328753-qwdxgk4z 98 12 preventing prevent VBG cord-328753-qwdxgk4z 98 13 definitive definitive JJ cord-328753-qwdxgk4z 98 14 diagnosis diagnosis NN cord-328753-qwdxgk4z 98 15 of of IN cord-328753-qwdxgk4z 98 16 infection infection NN cord-328753-qwdxgk4z 98 17 by by IN cord-328753-qwdxgk4z 98 18 T. t. NN cord-328753-qwdxgk4z 98 19 solium solium NN cord-328753-qwdxgk4z 98 20 [ [ -LRB- cord-328753-qwdxgk4z 98 21 57 57 CD cord-328753-qwdxgk4z 98 22 ] ] -RRB- cord-328753-qwdxgk4z 98 23 . . . cord-328753-qwdxgk4z 99 1 Indeed indeed RB cord-328753-qwdxgk4z 99 2 , , , cord-328753-qwdxgk4z 99 3 specific specific JJ cord-328753-qwdxgk4z 99 4 binders binder NNS cord-328753-qwdxgk4z 99 5 are be VBP cord-328753-qwdxgk4z 99 6 needed need VBN cord-328753-qwdxgk4z 99 7 . . . cord-328753-qwdxgk4z 100 1 Deckers Deckers NNP cord-328753-qwdxgk4z 100 2 et et FW cord-328753-qwdxgk4z 100 3 al al NNP cord-328753-qwdxgk4z 100 4 . . . cord-328753-qwdxgk4z 101 1 [ [ -LRB- cord-328753-qwdxgk4z 101 2 58 58 CD cord-328753-qwdxgk4z 101 3 ] ] -RRB- cord-328753-qwdxgk4z 101 4 have have VBP cord-328753-qwdxgk4z 101 5 isolated isolate VBN cord-328753-qwdxgk4z 101 6 VHHs vhh NNS cord-328753-qwdxgk4z 101 7 specific specific JJ cord-328753-qwdxgk4z 101 8 for for IN cord-328753-qwdxgk4z 101 9 a a DT cord-328753-qwdxgk4z 101 10 glycoprotein glycoprotein NN cord-328753-qwdxgk4z 101 11 of of IN cord-328753-qwdxgk4z 101 12 T. t. NN cord-328753-qwdxgk4z 101 13 solium solium NN cord-328753-qwdxgk4z 101 14 that that WDT cord-328753-qwdxgk4z 101 15 do do VBP cord-328753-qwdxgk4z 101 16 not not RB cord-328753-qwdxgk4z 101 17 cross cross VB cord-328753-qwdxgk4z 101 18 react react VB cord-328753-qwdxgk4z 101 19 with with IN cord-328753-qwdxgk4z 101 20 other other JJ cord-328753-qwdxgk4z 101 21 Taenia Taenia NNP cord-328753-qwdxgk4z 101 22 species specie NNS cord-328753-qwdxgk4z 101 23 and and CC cord-328753-qwdxgk4z 101 24 a a DT cord-328753-qwdxgk4z 101 25 sandwich sandwich NN cord-328753-qwdxgk4z 101 26 ELISA ELISA NNP cord-328753-qwdxgk4z 101 27 has have VBZ cord-328753-qwdxgk4z 101 28 been be VBN cord-328753-qwdxgk4z 101 29 developed develop VBN cord-328753-qwdxgk4z 101 30 . . . cord-328753-qwdxgk4z 102 1 This this DT cord-328753-qwdxgk4z 102 2 serodiagnostic serodiagnostic JJ cord-328753-qwdxgk4z 102 3 test test NN cord-328753-qwdxgk4z 102 4 could could MD cord-328753-qwdxgk4z 102 5 be be VB cord-328753-qwdxgk4z 102 6 helpful helpful JJ cord-328753-qwdxgk4z 102 7 in in IN cord-328753-qwdxgk4z 102 8 pigs pig NNS cord-328753-qwdxgk4z 102 9 for for IN cord-328753-qwdxgk4z 102 10 epidemiological epidemiological JJ cord-328753-qwdxgk4z 102 11 studies study NNS cord-328753-qwdxgk4z 102 12 and and CC cord-328753-qwdxgk4z 102 13 monitoring monitor VBG cord-328753-qwdxgk4z 102 14 the the DT cord-328753-qwdxgk4z 102 15 efficacy efficacy NN cord-328753-qwdxgk4z 102 16 of of IN cord-328753-qwdxgk4z 102 17 control control NN cord-328753-qwdxgk4z 102 18 programs program NNS cord-328753-qwdxgk4z 102 19 . . . cord-328753-qwdxgk4z 103 1 African african JJ cord-328753-qwdxgk4z 103 2 trypanosomiasis trypanosomiasis NN cord-328753-qwdxgk4z 103 3 ( ( -LRB- cord-328753-qwdxgk4z 103 4 AT at IN cord-328753-qwdxgk4z 103 5 ) ) -RRB- cord-328753-qwdxgk4z 103 6 , , , cord-328753-qwdxgk4z 103 7 or or CC cord-328753-qwdxgk4z 103 8 sleeping sleep VBG cord-328753-qwdxgk4z 103 9 sickness sickness NN cord-328753-qwdxgk4z 103 10 , , , cord-328753-qwdxgk4z 103 11 is be VBZ cord-328753-qwdxgk4z 103 12 mainly mainly RB cord-328753-qwdxgk4z 103 13 caused cause VBN cord-328753-qwdxgk4z 103 14 by by IN cord-328753-qwdxgk4z 103 15 a a DT cord-328753-qwdxgk4z 103 16 unicellular unicellular JJ cord-328753-qwdxgk4z 103 17 flagellated flagellated JJ cord-328753-qwdxgk4z 103 18 protozoan protozoan NN cord-328753-qwdxgk4z 103 19 parasite parasite NN cord-328753-qwdxgk4z 103 20 , , , cord-328753-qwdxgk4z 103 21 Trypanosoma Trypanosoma NNP cord-328753-qwdxgk4z 103 22 brucei brucei NNP cord-328753-qwdxgk4z 103 23 gambiense gambiense NN cord-328753-qwdxgk4z 103 24 , , , cord-328753-qwdxgk4z 103 25 belonging belong VBG cord-328753-qwdxgk4z 103 26 to to IN cord-328753-qwdxgk4z 103 27 the the DT cord-328753-qwdxgk4z 103 28 genus genus NN cord-328753-qwdxgk4z 103 29 Trypanosoma Trypanosoma NNP cord-328753-qwdxgk4z 103 30 . . . cord-328753-qwdxgk4z 104 1 AT at IN cord-328753-qwdxgk4z 104 2 affects affect VBZ cord-328753-qwdxgk4z 104 3 mainly mainly RB cord-328753-qwdxgk4z 104 4 remote remote JJ cord-328753-qwdxgk4z 104 5 rural rural JJ cord-328753-qwdxgk4z 104 6 areas area NNS cord-328753-qwdxgk4z 104 7 and and CC cord-328753-qwdxgk4z 104 8 its -PRON- PRP$ cord-328753-qwdxgk4z 104 9 distribution distribution NN cord-328753-qwdxgk4z 105 1 coincides coincide VBZ cord-328753-qwdxgk4z 105 2 mostly mostly RB cord-328753-qwdxgk4z 105 3 with with IN cord-328753-qwdxgk4z 105 4 the the DT cord-328753-qwdxgk4z 105 5 habitat habitat NN cord-328753-qwdxgk4z 105 6 of of IN cord-328753-qwdxgk4z 105 7 the the DT cord-328753-qwdxgk4z 105 8 hematophagous hematophagous JJ cord-328753-qwdxgk4z 105 9 insect insect NN cord-328753-qwdxgk4z 105 10 vector vector NN cord-328753-qwdxgk4z 105 11 , , , cord-328753-qwdxgk4z 105 12 i.e. i.e. FW cord-328753-qwdxgk4z 105 13 , , , cord-328753-qwdxgk4z 105 14 the the DT cord-328753-qwdxgk4z 105 15 tsetse tsetse NN cord-328753-qwdxgk4z 105 16 fly fly NN cord-328753-qwdxgk4z 105 17 ( ( -LRB- cord-328753-qwdxgk4z 105 18 Glossina Glossina NNP cord-328753-qwdxgk4z 105 19 sp sp NN cord-328753-qwdxgk4z 105 20 ) ) -RRB- cord-328753-qwdxgk4z 106 1 [ [ -LRB- cord-328753-qwdxgk4z 106 2 59 59 CD cord-328753-qwdxgk4z 106 3 ] ] -RRB- cord-328753-qwdxgk4z 106 4 . . . cord-328753-qwdxgk4z 107 1 Multiple multiple JJ cord-328753-qwdxgk4z 107 2 VHHs vhh NNS cord-328753-qwdxgk4z 107 3 have have VBP cord-328753-qwdxgk4z 107 4 already already RB cord-328753-qwdxgk4z 107 5 been be VBN cord-328753-qwdxgk4z 107 6 generated generate VBN cord-328753-qwdxgk4z 107 7 against against IN cord-328753-qwdxgk4z 107 8 the the DT cord-328753-qwdxgk4z 107 9 parasite parasite NN cord-328753-qwdxgk4z 107 10 ( ( -LRB- cord-328753-qwdxgk4z 107 11 for for IN cord-328753-qwdxgk4z 107 12 a a DT cord-328753-qwdxgk4z 107 13 review review NN cord-328753-qwdxgk4z 107 14 , , , cord-328753-qwdxgk4z 107 15 [ [ -LRB- cord-328753-qwdxgk4z 107 16 60 60 CD cord-328753-qwdxgk4z 107 17 ] ] -RRB- cord-328753-qwdxgk4z 107 18 ) ) -RRB- cord-328753-qwdxgk4z 107 19 . . . cord-328753-qwdxgk4z 108 1 Trypanolytic Trypanolytic NNP cord-328753-qwdxgk4z 108 2 VHH VHH NNP cord-328753-qwdxgk4z 108 3 An46 An46 NNP cord-328753-qwdxgk4z 108 4 disturbs disturb VBZ cord-328753-qwdxgk4z 108 5 the the DT cord-328753-qwdxgk4z 108 6 endocytic endocytic JJ cord-328753-qwdxgk4z 108 7 machinery machinery NN cord-328753-qwdxgk4z 108 8 of of IN cord-328753-qwdxgk4z 108 9 the the DT cord-328753-qwdxgk4z 108 10 parasite parasite NN cord-328753-qwdxgk4z 108 11 in in IN cord-328753-qwdxgk4z 108 12 the the DT cord-328753-qwdxgk4z 108 13 flagellar flagellar JJ cord-328753-qwdxgk4z 108 14 pocket pocket NN cord-328753-qwdxgk4z 108 15 of of IN cord-328753-qwdxgk4z 108 16 the the DT cord-328753-qwdxgk4z 108 17 parasite parasite NN cord-328753-qwdxgk4z 108 18 . . . cord-328753-qwdxgk4z 109 1 Nontrypanolytic Nontrypanolytic NNP cord-328753-qwdxgk4z 109 2 VHH VHH NNP cord-328753-qwdxgk4z 109 3 An33 An33 NNP cord-328753-qwdxgk4z 109 4 was be VBD cord-328753-qwdxgk4z 109 5 made make VBN cord-328753-qwdxgk4z 109 6 more more RBR cord-328753-qwdxgk4z 109 7 potent potent JJ cord-328753-qwdxgk4z 109 8 by by IN cord-328753-qwdxgk4z 109 9 linking link VBG cord-328753-qwdxgk4z 109 10 the the DT cord-328753-qwdxgk4z 109 11 nontoxic nontoxic JJ cord-328753-qwdxgk4z 109 12 prodrug prodrug NN cord-328753-qwdxgk4z 109 13 cephalosporin cephalosporin NN cord-328753-qwdxgk4z 109 14 mustard mustard NN cord-328753-qwdxgk4z 109 15 ( ( -LRB- cord-328753-qwdxgk4z 109 16 CCM CCM NNP cord-328753-qwdxgk4z 109 17 ) ) -RRB- cord-328753-qwdxgk4z 109 18 onto onto IN cord-328753-qwdxgk4z 109 19 the the DT cord-328753-qwdxgk4z 109 20 highly highly RB cord-328753-qwdxgk4z 109 21 toxic toxic JJ cord-328753-qwdxgk4z 109 22 PDM pdm NN cord-328753-qwdxgk4z 109 23 at at IN cord-328753-qwdxgk4z 109 24 the the DT cord-328753-qwdxgk4z 109 25 surface surface NN cord-328753-qwdxgk4z 109 26 of of IN cord-328753-qwdxgk4z 109 27 the the DT cord-328753-qwdxgk4z 109 28 parasite parasite NN cord-328753-qwdxgk4z 109 29 [ [ -LRB- cord-328753-qwdxgk4z 109 30 61 61 CD cord-328753-qwdxgk4z 109 31 ] ] -RRB- cord-328753-qwdxgk4z 109 32 . . . cord-328753-qwdxgk4z 110 1 Linking link VBG cord-328753-qwdxgk4z 110 2 this this DT cord-328753-qwdxgk4z 110 3 VHH VHH NNP cord-328753-qwdxgk4z 110 4 to to IN cord-328753-qwdxgk4z 110 5 apolipoprotein apolipoprotein NN cord-328753-qwdxgk4z 110 6 L l NN cord-328753-qwdxgk4z 110 7 - - : cord-328753-qwdxgk4z 110 8 I -PRON- PRP cord-328753-qwdxgk4z 110 9 resulted result VBD cord-328753-qwdxgk4z 110 10 in in IN cord-328753-qwdxgk4z 110 11 an an DT cord-328753-qwdxgk4z 110 12 immunotoxin immunotoxin NN cord-328753-qwdxgk4z 110 13 that that WDT cord-328753-qwdxgk4z 110 14 lyses lyse VBZ cord-328753-qwdxgk4z 110 15 almost almost RB cord-328753-qwdxgk4z 110 16 all all DT cord-328753-qwdxgk4z 110 17 trypanosomes trypanosome NNS cord-328753-qwdxgk4z 110 18 [ [ -LRB- cord-328753-qwdxgk4z 110 19 18 18 CD cord-328753-qwdxgk4z 110 20 ] ] -RRB- cord-328753-qwdxgk4z 110 21 . . . cord-328753-qwdxgk4z 111 1 Another another DT cord-328753-qwdxgk4z 111 2 approach approach NN cord-328753-qwdxgk4z 111 3 is be VBZ cord-328753-qwdxgk4z 111 4 to to IN cord-328753-qwdxgk4z 111 5 couple couple NN cord-328753-qwdxgk4z 111 6 pentamidine pentamidine NNP cord-328753-qwdxgk4z 111 7 , , , cord-328753-qwdxgk4z 111 8 a a DT cord-328753-qwdxgk4z 111 9 first first JJ cord-328753-qwdxgk4z 111 10 - - HYPH cord-328753-qwdxgk4z 111 11 line line NN cord-328753-qwdxgk4z 111 12 antitrypanosomiasis antitrypanosomiasis NN cord-328753-qwdxgk4z 111 13 , , , cord-328753-qwdxgk4z 111 14 to to IN cord-328753-qwdxgk4z 111 15 VHH vhh NN cord-328753-qwdxgk4z 111 16 An33 An33 . cord-328753-qwdxgk4z 112 1 to to TO cord-328753-qwdxgk4z 112 2 effectively effectively RB cord-328753-qwdxgk4z 112 3 target target VB cord-328753-qwdxgk4z 112 4 the the DT cord-328753-qwdxgk4z 112 5 drug drug NN cord-328753-qwdxgk4z 112 6 to to IN cord-328753-qwdxgk4z 112 7 the the DT cord-328753-qwdxgk4z 112 8 parasite parasite NN cord-328753-qwdxgk4z 112 9 . . . cord-328753-qwdxgk4z 113 1 In in IN cord-328753-qwdxgk4z 113 2 vivo vivo NN cord-328753-qwdxgk4z 113 3 , , , cord-328753-qwdxgk4z 113 4 a a DT cord-328753-qwdxgk4z 113 5 ten ten CD cord-328753-qwdxgk4z 113 6 - - HYPH cord-328753-qwdxgk4z 113 7 fold fold NN cord-328753-qwdxgk4z 113 8 lower low JJR cord-328753-qwdxgk4z 113 9 dose dose NN cord-328753-qwdxgk4z 113 10 than than IN cord-328753-qwdxgk4z 113 11 the the DT cord-328753-qwdxgk4z 113 12 minimal minimal JJ cord-328753-qwdxgk4z 113 13 full full JJ cord-328753-qwdxgk4z 113 14 curative curative JJ cord-328753-qwdxgk4z 113 15 dose dose NN cord-328753-qwdxgk4z 113 16 of of IN cord-328753-qwdxgk4z 113 17 free free JJ cord-328753-qwdxgk4z 113 18 pentamidin pentamidin NNS cord-328753-qwdxgk4z 113 19 incorporated incorporate VBN cord-328753-qwdxgk4z 113 20 into into IN cord-328753-qwdxgk4z 113 21 this this DT cord-328753-qwdxgk4z 113 22 conjugate conjugate NN cord-328753-qwdxgk4z 113 23 cured cure VBN cord-328753-qwdxgk4z 113 24 all all DT cord-328753-qwdxgk4z 113 25 infected infect VBN cord-328753-qwdxgk4z 113 26 mice mouse NNS cord-328753-qwdxgk4z 113 27 , , , cord-328753-qwdxgk4z 113 28 wheras whera NNS cord-328753-qwdxgk4z 113 29 a a DT cord-328753-qwdxgk4z 113 30 100-fold 100-fold CD cord-328753-qwdxgk4z 113 31 lower low JJR cord-328753-qwdxgk4z 113 32 dose dose NN cord-328753-qwdxgk4z 113 33 cured cure VBN cord-328753-qwdxgk4z 113 34 60 60 CD cord-328753-qwdxgk4z 113 35 % % NN cord-328753-qwdxgk4z 113 36 of of IN cord-328753-qwdxgk4z 113 37 them -PRON- PRP cord-328753-qwdxgk4z 113 38 [ [ -LRB- cord-328753-qwdxgk4z 113 39 62 62 CD cord-328753-qwdxgk4z 113 40 ] ] -RRB- cord-328753-qwdxgk4z 113 41 . . . cord-328753-qwdxgk4z 114 1 Parasite parasite NN cord-328753-qwdxgk4z 114 2 development development NN cord-328753-qwdxgk4z 114 3 in in IN cord-328753-qwdxgk4z 114 4 the the DT cord-328753-qwdxgk4z 114 5 tsetse tsetse NN cord-328753-qwdxgk4z 114 6 fly fly NN cord-328753-qwdxgk4z 114 7 and and CC cord-328753-qwdxgk4z 114 8 subsequent subsequent JJ cord-328753-qwdxgk4z 114 9 spread spread NN cord-328753-qwdxgk4z 114 10 of of IN cord-328753-qwdxgk4z 114 11 the the DT cord-328753-qwdxgk4z 114 12 parasite parasite NN cord-328753-qwdxgk4z 114 13 can can MD cord-328753-qwdxgk4z 114 14 be be VB cord-328753-qwdxgk4z 114 15 controlled control VBN cord-328753-qwdxgk4z 114 16 through through IN cord-328753-qwdxgk4z 114 17 the the DT cord-328753-qwdxgk4z 114 18 expression expression NN cord-328753-qwdxgk4z 114 19 of of IN cord-328753-qwdxgk4z 114 20 trypanolytic trypanolytic JJ cord-328753-qwdxgk4z 114 21 VHHs vhh NNS cord-328753-qwdxgk4z 114 22 in in IN cord-328753-qwdxgk4z 114 23 genetically genetically RB cord-328753-qwdxgk4z 114 24 modified modify VBN cord-328753-qwdxgk4z 114 25 tsetse tsetse NN cord-328753-qwdxgk4z 114 26 fly fly VB cord-328753-qwdxgk4z 114 27 symbionts symbiont NNS cord-328753-qwdxgk4z 114 28 [ [ -LRB- cord-328753-qwdxgk4z 114 29 63 63 CD cord-328753-qwdxgk4z 114 30 ] ] -RRB- cord-328753-qwdxgk4z 114 31 . . . cord-328753-qwdxgk4z 115 1 In in IN cord-328753-qwdxgk4z 115 2 addition addition NN cord-328753-qwdxgk4z 115 3 , , , cord-328753-qwdxgk4z 115 4 VHHs vhh NNS cord-328753-qwdxgk4z 115 5 that that WDT cord-328753-qwdxgk4z 115 6 target target VBP cord-328753-qwdxgk4z 115 7 the the DT cord-328753-qwdxgk4z 115 8 paraflagellar paraflagellar NNP cord-328753-qwdxgk4z 115 9 rod rod NNP cord-328753-qwdxgk4z 115 10 protein protein NN cord-328753-qwdxgk4z 115 11 of of IN cord-328753-qwdxgk4z 115 12 varioius varioius NNP cord-328753-qwdxgk4z 115 13 trypanosomes trypanosome NNS cord-328753-qwdxgk4z 115 14 have have VBP cord-328753-qwdxgk4z 115 15 been be VBN cord-328753-qwdxgk4z 115 16 described describe VBN cord-328753-qwdxgk4z 115 17 , , , cord-328753-qwdxgk4z 115 18 but but CC cord-328753-qwdxgk4z 115 19 are be VBP cord-328753-qwdxgk4z 115 20 mainly mainly RB cord-328753-qwdxgk4z 115 21 useful useful JJ cord-328753-qwdxgk4z 115 22 as as IN cord-328753-qwdxgk4z 115 23 diagnostic diagnostic JJ cord-328753-qwdxgk4z 115 24 markers marker NNS cord-328753-qwdxgk4z 115 25 of of IN cord-328753-qwdxgk4z 115 26 trypanosiomasis trypanosiomasis NN cord-328753-qwdxgk4z 115 27 [ [ -LRB- cord-328753-qwdxgk4z 115 28 64 64 CD cord-328753-qwdxgk4z 115 29 ] ] -RRB- cord-328753-qwdxgk4z 115 30 . . . cord-328753-qwdxgk4z 116 1 A a DT cord-328753-qwdxgk4z 116 2 VHH vhh NN cord-328753-qwdxgk4z 116 3 ( ( -LRB- cord-328753-qwdxgk4z 116 4 Nb474 Nb474 NNP cord-328753-qwdxgk4z 116 5 ) ) -RRB- cord-328753-qwdxgk4z 116 6 directed direct VBN cord-328753-qwdxgk4z 116 7 against against IN cord-328753-qwdxgk4z 116 8 T. t. NN cord-328753-qwdxgk4z 116 9 congolese congolese JJ cord-328753-qwdxgk4z 116 10 aldolase aldolase NN cord-328753-qwdxgk4z 116 11 ( ( -LRB- cord-328753-qwdxgk4z 116 12 TcoALD TcoALD NNP cord-328753-qwdxgk4z 116 13 ) ) -RRB- cord-328753-qwdxgk4z 116 14 has have VBZ cord-328753-qwdxgk4z 116 15 been be VBN cord-328753-qwdxgk4z 116 16 developped developpe VBN cord-328753-qwdxgk4z 116 17 for for IN cord-328753-qwdxgk4z 116 18 a a DT cord-328753-qwdxgk4z 116 19 sandwich sandwich NN cord-328753-qwdxgk4z 116 20 immunoassay immunoassay NN cord-328753-qwdxgk4z 116 21 . . . cord-328753-qwdxgk4z 117 1 This this DT cord-328753-qwdxgk4z 117 2 VHH vhh NN cord-328753-qwdxgk4z 117 3 is be VBZ cord-328753-qwdxgk4z 117 4 highly highly RB cord-328753-qwdxgk4z 117 5 specific specific JJ cord-328753-qwdxgk4z 117 6 and and CC cord-328753-qwdxgk4z 117 7 did do VBD cord-328753-qwdxgk4z 117 8 not not RB cord-328753-qwdxgk4z 117 9 recognize recognize VB cord-328753-qwdxgk4z 117 10 other other JJ cord-328753-qwdxgk4z 117 11 trypanosomes trypanosome NNS cord-328753-qwdxgk4z 117 12 such such JJ cord-328753-qwdxgk4z 117 13 as as IN cord-328753-qwdxgk4z 117 14 T. T. NNP cord-328753-qwdxgk4z 117 15 brucei brucei NNP cord-328753-qwdxgk4z 117 16 brucei brucei NN cord-328753-qwdxgk4z 117 17 , , , cord-328753-qwdxgk4z 117 18 T. t. NN cord-328753-qwdxgk4z 117 19 vivax vivax NN cord-328753-qwdxgk4z 117 20 and and CC cord-328753-qwdxgk4z 117 21 T. t. NN cord-328753-qwdxgk4z 117 22 evansi evansi NN cord-328753-qwdxgk4z 117 23 [ [ -LRB- cord-328753-qwdxgk4z 117 24 65 65 CD cord-328753-qwdxgk4z 117 25 , , , cord-328753-qwdxgk4z 117 26 66 66 CD cord-328753-qwdxgk4z 117 27 ] ] -RRB- cord-328753-qwdxgk4z 117 28 . . . cord-328753-qwdxgk4z 118 1 Influenza Influenza NNP cord-328753-qwdxgk4z 118 2 A a DT cord-328753-qwdxgk4z 118 3 viruses virus NNS cord-328753-qwdxgk4z 118 4 ( ( -LRB- cord-328753-qwdxgk4z 118 5 IAV IAV NNP cord-328753-qwdxgk4z 118 6 ) ) -RRB- cord-328753-qwdxgk4z 118 7 , , , cord-328753-qwdxgk4z 118 8 members member NNS cord-328753-qwdxgk4z 118 9 of of IN cord-328753-qwdxgk4z 118 10 the the DT cord-328753-qwdxgk4z 118 11 RNA RNA NNP cord-328753-qwdxgk4z 118 12 family family NN cord-328753-qwdxgk4z 118 13 Orthomyxoviridae Orthomyxoviridae NNP cord-328753-qwdxgk4z 118 14 , , , cord-328753-qwdxgk4z 118 15 consist consist VBP cord-328753-qwdxgk4z 118 16 of of IN cord-328753-qwdxgk4z 118 17 up up IN cord-328753-qwdxgk4z 118 18 to to TO cord-328753-qwdxgk4z 118 19 144 144 CD cord-328753-qwdxgk4z 118 20 subtypes subtype NNS cord-328753-qwdxgk4z 118 21 , , , cord-328753-qwdxgk4z 118 22 depending depend VBG cord-328753-qwdxgk4z 118 23 on on IN cord-328753-qwdxgk4z 118 24 the the DT cord-328753-qwdxgk4z 118 25 variation variation NN cord-328753-qwdxgk4z 118 26 / / SYM cord-328753-qwdxgk4z 118 27 combination combination NN cord-328753-qwdxgk4z 118 28 of of IN cord-328753-qwdxgk4z 118 29 the the DT cord-328753-qwdxgk4z 118 30 surface surface NN cord-328753-qwdxgk4z 118 31 glycoproteins glycoprotein NNS cord-328753-qwdxgk4z 118 32 , , , cord-328753-qwdxgk4z 118 33 hemagglutinin hemagglutinin NN cord-328753-qwdxgk4z 118 34 and and CC cord-328753-qwdxgk4z 118 35 neuraminidase neuraminidase NN cord-328753-qwdxgk4z 118 36 . . . cord-328753-qwdxgk4z 119 1 IAV IAV NNP cord-328753-qwdxgk4z 119 2 are be VBP cord-328753-qwdxgk4z 119 3 further further RB cord-328753-qwdxgk4z 119 4 classified classify VBN cord-328753-qwdxgk4z 119 5 as as IN cord-328753-qwdxgk4z 119 6 human human JJ cord-328753-qwdxgk4z 119 7 , , , cord-328753-qwdxgk4z 119 8 swine swine NN cord-328753-qwdxgk4z 119 9 ( ( -LRB- cord-328753-qwdxgk4z 119 10 SIV SIV NNP cord-328753-qwdxgk4z 119 11 ) ) -RRB- cord-328753-qwdxgk4z 119 12 , , , cord-328753-qwdxgk4z 119 13 bat bat NN cord-328753-qwdxgk4z 119 14 , , , cord-328753-qwdxgk4z 119 15 equine equine NN cord-328753-qwdxgk4z 119 16 , , , cord-328753-qwdxgk4z 119 17 or or CC cord-328753-qwdxgk4z 119 18 avian avian JJ cord-328753-qwdxgk4z 119 19 influenza influenza NN cord-328753-qwdxgk4z 119 20 viruses virus NNS cord-328753-qwdxgk4z 119 21 ( ( -LRB- cord-328753-qwdxgk4z 119 22 AIV AIV NNP cord-328753-qwdxgk4z 119 23 ) ) -RRB- cord-328753-qwdxgk4z 119 24 . . . cord-328753-qwdxgk4z 120 1 SIV SIV NNP cord-328753-qwdxgk4z 120 2 and and CC cord-328753-qwdxgk4z 120 3 AIV AIV NNP cord-328753-qwdxgk4z 120 4 are be VBP cord-328753-qwdxgk4z 120 5 transmitted transmit VBN cord-328753-qwdxgk4z 120 6 from from IN cord-328753-qwdxgk4z 120 7 pigs pig NNS cord-328753-qwdxgk4z 120 8 or or CC cord-328753-qwdxgk4z 120 9 birds bird NNS cord-328753-qwdxgk4z 120 10 to to IN cord-328753-qwdxgk4z 120 11 humans human NNS cord-328753-qwdxgk4z 120 12 , , , cord-328753-qwdxgk4z 120 13 respectively respectively RB cord-328753-qwdxgk4z 120 14 , , , cord-328753-qwdxgk4z 120 15 mostly mostly RB cord-328753-qwdxgk4z 120 16 via via IN cord-328753-qwdxgk4z 120 17 direct direct JJ cord-328753-qwdxgk4z 120 18 contact contact NN cord-328753-qwdxgk4z 120 19 with with IN cord-328753-qwdxgk4z 120 20 infected infected JJ cord-328753-qwdxgk4z 120 21 animals animal NNS cord-328753-qwdxgk4z 120 22 . . . cord-328753-qwdxgk4z 121 1 The the DT cord-328753-qwdxgk4z 121 2 infection infection NN cord-328753-qwdxgk4z 121 3 in in IN cord-328753-qwdxgk4z 121 4 humans human NNS cord-328753-qwdxgk4z 121 5 ranges range VBZ cord-328753-qwdxgk4z 121 6 from from IN cord-328753-qwdxgk4z 121 7 mild mild JJ cord-328753-qwdxgk4z 121 8 selflimiting selflimite VBG cord-328753-qwdxgk4z 121 9 respiratory respiratory NN cord-328753-qwdxgk4z 121 10 - - HYPH cord-328753-qwdxgk4z 121 11 like like JJ cord-328753-qwdxgk4z 121 12 illness illness NN cord-328753-qwdxgk4z 121 13 to to IN cord-328753-qwdxgk4z 121 14 death death NN cord-328753-qwdxgk4z 121 15 . . . cord-328753-qwdxgk4z 122 1 However however RB cord-328753-qwdxgk4z 122 2 , , , cord-328753-qwdxgk4z 122 3 pandemic pandemic NN cord-328753-qwdxgk4z 122 4 outbreaks outbreak NNS cord-328753-qwdxgk4z 122 5 remain remain VBP cord-328753-qwdxgk4z 122 6 unpredictable unpredictable JJ cord-328753-qwdxgk4z 122 7 , , , cord-328753-qwdxgk4z 122 8 as as IN cord-328753-qwdxgk4z 122 9 illustrated illustrate VBN cord-328753-qwdxgk4z 122 10 by by IN cord-328753-qwdxgk4z 122 11 the the DT cord-328753-qwdxgk4z 122 12 2009 2009 CD cord-328753-qwdxgk4z 122 13 H1N1 H1N1 NNP cord-328753-qwdxgk4z 122 14 virus virus NN cord-328753-qwdxgk4z 122 15 ( ( -LRB- cord-328753-qwdxgk4z 122 16 also also RB cord-328753-qwdxgk4z 122 17 named name VBN cord-328753-qwdxgk4z 122 18 Mexican mexican JJ cord-328753-qwdxgk4z 122 19 flu flu NN cord-328753-qwdxgk4z 122 20 ) ) -RRB- cord-328753-qwdxgk4z 122 21 and and CC cord-328753-qwdxgk4z 122 22 H5N1 H5N1 NNP cord-328753-qwdxgk4z 122 23 virus virus NN cord-328753-qwdxgk4z 122 24 . . . cord-328753-qwdxgk4z 123 1 Occasional occasional JJ cord-328753-qwdxgk4z 123 2 zoonotic zoonotic JJ cord-328753-qwdxgk4z 123 3 infections infection NNS cord-328753-qwdxgk4z 123 4 with with IN cord-328753-qwdxgk4z 123 5 these these DT cord-328753-qwdxgk4z 123 6 viruses virus NNS cord-328753-qwdxgk4z 123 7 and and CC cord-328753-qwdxgk4z 123 8 their -PRON- PRP$ cord-328753-qwdxgk4z 123 9 high high JJ cord-328753-qwdxgk4z 123 10 propensity propensity NN cord-328753-qwdxgk4z 123 11 to to TO cord-328753-qwdxgk4z 123 12 reassort reassort VB cord-328753-qwdxgk4z 123 13 with with IN cord-328753-qwdxgk4z 123 14 SIV SIV NNP cord-328753-qwdxgk4z 123 15 have have VBP cord-328753-qwdxgk4z 123 16 earmarked earmark VBN cord-328753-qwdxgk4z 123 17 them -PRON- PRP cord-328753-qwdxgk4z 123 18 as as IN cord-328753-qwdxgk4z 123 19 a a DT cord-328753-qwdxgk4z 123 20 major major JJ cord-328753-qwdxgk4z 123 21 pandemic pandemic NN cord-328753-qwdxgk4z 123 22 threat threat NN cord-328753-qwdxgk4z 123 23 [ [ -LRB- cord-328753-qwdxgk4z 123 24 67 67 CD cord-328753-qwdxgk4z 123 25 ] ] -RRB- cord-328753-qwdxgk4z 123 26 . . . cord-328753-qwdxgk4z 124 1 Several several JJ cord-328753-qwdxgk4z 124 2 VHHs vhh NNS cord-328753-qwdxgk4z 124 3 specific specific JJ cord-328753-qwdxgk4z 124 4 for for IN cord-328753-qwdxgk4z 124 5 influenza influenza NN cord-328753-qwdxgk4z 124 6 viruses virus NNS cord-328753-qwdxgk4z 124 7 have have VBP cord-328753-qwdxgk4z 124 8 been be VBN cord-328753-qwdxgk4z 124 9 raised raise VBN cord-328753-qwdxgk4z 124 10 against against IN cord-328753-qwdxgk4z 124 11 the the DT cord-328753-qwdxgk4z 124 12 nucleoprotein nucleoprotein NNP cord-328753-qwdxgk4z 124 13 [ [ -LRB- cord-328753-qwdxgk4z 124 14 68 68 CD cord-328753-qwdxgk4z 124 15 ] ] -RRB- cord-328753-qwdxgk4z 124 16 and and CC cord-328753-qwdxgk4z 124 17 M2 M2 NNP cord-328753-qwdxgk4z 124 18 ion ion NN cord-328753-qwdxgk4z 124 19 channel channel NN cord-328753-qwdxgk4z 124 20 protein protein NN cord-328753-qwdxgk4z 124 21 [ [ -LRB- cord-328753-qwdxgk4z 124 22 69 69 CD cord-328753-qwdxgk4z 124 23 ] ] -RRB- cord-328753-qwdxgk4z 124 24 of of IN cord-328753-qwdxgk4z 124 25 Influenza Influenza NNP cord-328753-qwdxgk4z 124 26 A A NNP cord-328753-qwdxgk4z 124 27 , , , cord-328753-qwdxgk4z 124 28 and and CC cord-328753-qwdxgk4z 124 29 the the DT cord-328753-qwdxgk4z 124 30 neuraminidase neuraminidase NN cord-328753-qwdxgk4z 124 31 [ [ -LRB- cord-328753-qwdxgk4z 124 32 70 70 CD cord-328753-qwdxgk4z 124 33 ] ] -RRB- cord-328753-qwdxgk4z 124 34 and and CC cord-328753-qwdxgk4z 124 35 hemaglutinin hemaglutinin NNS cord-328753-qwdxgk4z 124 36 [ [ -LRB- cord-328753-qwdxgk4z 124 37 71 71 CD cord-328753-qwdxgk4z 124 38 ] ] -RRB- cord-328753-qwdxgk4z 124 39 of of IN cord-328753-qwdxgk4z 124 40 H5N1 H5N1 NNP cord-328753-qwdxgk4z 124 41 . . . cord-328753-qwdxgk4z 125 1 Most Most JJS cord-328753-qwdxgk4z 125 2 of of IN cord-328753-qwdxgk4z 125 3 these these DT cord-328753-qwdxgk4z 125 4 VHHs vhh NNS cord-328753-qwdxgk4z 125 5 can can MD cord-328753-qwdxgk4z 125 6 neutralize neutralize VB cord-328753-qwdxgk4z 125 7 influenza influenza NN cord-328753-qwdxgk4z 125 8 viruses virus NNS cord-328753-qwdxgk4z 125 9 . . . cord-328753-qwdxgk4z 126 1 Ploegh Ploegh NNP cord-328753-qwdxgk4z 126 2 et et NNP cord-328753-qwdxgk4z 126 3 al al NNP cord-328753-qwdxgk4z 126 4 . . . cord-328753-qwdxgk4z 127 1 [ [ -LRB- cord-328753-qwdxgk4z 127 2 57 57 CD cord-328753-qwdxgk4z 127 3 ] ] -RRB- cord-328753-qwdxgk4z 127 4 exploited exploit VBD cord-328753-qwdxgk4z 127 5 the the DT cord-328753-qwdxgk4z 127 6 ability ability NN cord-328753-qwdxgk4z 127 7 of of IN cord-328753-qwdxgk4z 127 8 VHHs vhh NNS cord-328753-qwdxgk4z 127 9 to to TO cord-328753-qwdxgk4z 127 10 bind bind VB cord-328753-qwdxgk4z 127 11 the the DT cord-328753-qwdxgk4z 127 12 intracellular intracellular JJ cord-328753-qwdxgk4z 127 13 nucleoprotein nucleoprotein NNP cord-328753-qwdxgk4z 127 14 protein protein NN cord-328753-qwdxgk4z 127 15 to to TO cord-328753-qwdxgk4z 127 16 block block VB cord-328753-qwdxgk4z 127 17 viral viral JJ cord-328753-qwdxgk4z 127 18 replication replication NN cord-328753-qwdxgk4z 127 19 , , , cord-328753-qwdxgk4z 127 20 leading lead VBG cord-328753-qwdxgk4z 127 21 to to IN cord-328753-qwdxgk4z 127 22 the the DT cord-328753-qwdxgk4z 127 23 possibility possibility NN cord-328753-qwdxgk4z 127 24 of of IN cord-328753-qwdxgk4z 127 25 creating create VBG cord-328753-qwdxgk4z 127 26 new new JJ cord-328753-qwdxgk4z 127 27 therapeutic therapeutic JJ cord-328753-qwdxgk4z 127 28 molecules molecule NNS cord-328753-qwdxgk4z 127 29 to to TO cord-328753-qwdxgk4z 127 30 prevent prevent VB cord-328753-qwdxgk4z 127 31 viral viral JJ cord-328753-qwdxgk4z 127 32 escape escape NN cord-328753-qwdxgk4z 127 33 due due IN cord-328753-qwdxgk4z 127 34 to to IN cord-328753-qwdxgk4z 127 35 antigenic antigenic JJ cord-328753-qwdxgk4z 127 36 variation variation NN cord-328753-qwdxgk4z 127 37 . . . cord-328753-qwdxgk4z 128 1 An an DT cord-328753-qwdxgk4z 128 2 alternative alternative JJ cord-328753-qwdxgk4z 128 3 approach approach NN cord-328753-qwdxgk4z 128 4 has have VBZ cord-328753-qwdxgk4z 128 5 been be VBN cord-328753-qwdxgk4z 128 6 to to TO cord-328753-qwdxgk4z 128 7 create create VB cord-328753-qwdxgk4z 128 8 multivalent multivalent JJ cord-328753-qwdxgk4z 128 9 VHHs vhh NNS cord-328753-qwdxgk4z 128 10 to to TO cord-328753-qwdxgk4z 128 11 increase increase VB cord-328753-qwdxgk4z 128 12 their -PRON- PRP$ cord-328753-qwdxgk4z 128 13 antiviral antiviral JJ cord-328753-qwdxgk4z 128 14 potential potential NN cord-328753-qwdxgk4z 128 15 : : : cord-328753-qwdxgk4z 128 16 dimers dimer NNS cord-328753-qwdxgk4z 128 17 made make VBN cord-328753-qwdxgk4z 128 18 by by IN cord-328753-qwdxgk4z 128 19 the the DT cord-328753-qwdxgk4z 128 20 fusion fusion NN cord-328753-qwdxgk4z 128 21 of of IN cord-328753-qwdxgk4z 128 22 two two CD cord-328753-qwdxgk4z 128 23 neutralizing neutralize VBG cord-328753-qwdxgk4z 128 24 VHHs vhh NNS cord-328753-qwdxgk4z 128 25 [ [ -LRB- cord-328753-qwdxgk4z 128 26 68 68 CD cord-328753-qwdxgk4z 128 27 , , , cord-328753-qwdxgk4z 128 28 72 72 CD cord-328753-qwdxgk4z 128 29 ] ] -RRB- cord-328753-qwdxgk4z 128 30 or or CC cord-328753-qwdxgk4z 128 31 a a DT cord-328753-qwdxgk4z 128 32 VHH vhh NN cord-328753-qwdxgk4z 128 33 - - HYPH cord-328753-qwdxgk4z 128 34 fused fuse VBN cord-328753-qwdxgk4z 128 35 to to IN cord-328753-qwdxgk4z 128 36 an an DT cord-328753-qwdxgk4z 128 37 immunoglobulin immunoglobulin NN cord-328753-qwdxgk4z 128 38 Fc Fc NNP cord-328753-qwdxgk4z 128 39 region region NN cord-328753-qwdxgk4z 128 40 [ [ -LRB- cord-328753-qwdxgk4z 128 41 68 68 CD cord-328753-qwdxgk4z 128 42 ] ] -RRB- cord-328753-qwdxgk4z 128 43 . . . cord-328753-qwdxgk4z 129 1 In in IN cord-328753-qwdxgk4z 129 2 vitro vitro FW cord-328753-qwdxgk4z 129 3 antiviral antiviral JJ cord-328753-qwdxgk4z 129 4 potency potency NN cord-328753-qwdxgk4z 129 5 was be VBD cord-328753-qwdxgk4z 129 6 increased increase VBN cord-328753-qwdxgk4z 129 7 from from IN cord-328753-qwdxgk4z 129 8 1 1 CD cord-328753-qwdxgk4z 129 9 to to IN cord-328753-qwdxgk4z 129 10 2 2 CD cord-328753-qwdxgk4z 129 11 logs log NNS cord-328753-qwdxgk4z 129 12 relative relative JJ cord-328753-qwdxgk4z 129 13 to to IN cord-328753-qwdxgk4z 129 14 the the DT cord-328753-qwdxgk4z 129 15 monomeric monomeric JJ cord-328753-qwdxgk4z 129 16 VHH vhh NN cord-328753-qwdxgk4z 129 17 . . . cord-328753-qwdxgk4z 130 1 The the DT cord-328753-qwdxgk4z 130 2 rabies rabies NN cord-328753-qwdxgk4z 130 3 virus virus NN cord-328753-qwdxgk4z 130 4 ( ( -LRB- cord-328753-qwdxgk4z 130 5 RABV RABV NNP cord-328753-qwdxgk4z 130 6 ) ) -RRB- cord-328753-qwdxgk4z 130 7 belongs belong VBZ cord-328753-qwdxgk4z 130 8 to to IN cord-328753-qwdxgk4z 130 9 the the DT cord-328753-qwdxgk4z 130 10 genus genus NN cord-328753-qwdxgk4z 130 11 Lyssavirus Lyssavirus NNP cord-328753-qwdxgk4z 130 12 of of IN cord-328753-qwdxgk4z 130 13 the the DT cord-328753-qwdxgk4z 130 14 RNA RNA NNP cord-328753-qwdxgk4z 130 15 family family NN cord-328753-qwdxgk4z 130 16 Rhabdoviridae Rhabdoviridae NNP cord-328753-qwdxgk4z 130 17 , , , cord-328753-qwdxgk4z 130 18 within within IN cord-328753-qwdxgk4z 130 19 the the DT cord-328753-qwdxgk4z 130 20 order order NN cord-328753-qwdxgk4z 130 21 Mononegavirales Mononegavirales NNP cord-328753-qwdxgk4z 130 22 . . . cord-328753-qwdxgk4z 131 1 Despite despite IN cord-328753-qwdxgk4z 131 2 the the DT cord-328753-qwdxgk4z 131 3 availability availability NN cord-328753-qwdxgk4z 131 4 of of IN cord-328753-qwdxgk4z 131 5 a a DT cord-328753-qwdxgk4z 131 6 vaccine vaccine NN cord-328753-qwdxgk4z 131 7 against against IN cord-328753-qwdxgk4z 131 8 rabies rabies NN cord-328753-qwdxgk4z 131 9 virus virus NN cord-328753-qwdxgk4z 131 10 ( ( -LRB- cord-328753-qwdxgk4z 131 11 RABV RABV NNP cord-328753-qwdxgk4z 131 12 ) ) -RRB- cord-328753-qwdxgk4z 131 13 , , , cord-328753-qwdxgk4z 131 14 rabies rabies NN cord-328753-qwdxgk4z 131 15 continues continue VBZ cord-328753-qwdxgk4z 131 16 to to TO cord-328753-qwdxgk4z 131 17 claim claim VB cord-328753-qwdxgk4z 131 18 55,000 55,000 CD cord-328753-qwdxgk4z 131 19 human human JJ cord-328753-qwdxgk4z 131 20 lives life NNS cord-328753-qwdxgk4z 131 21 per per IN cord-328753-qwdxgk4z 131 22 year year NN cord-328753-qwdxgk4z 131 23 , , , cord-328753-qwdxgk4z 131 24 mostly mostly RB cord-328753-qwdxgk4z 131 25 in in IN cord-328753-qwdxgk4z 131 26 developing develop VBG cord-328753-qwdxgk4z 131 27 countries country NNS cord-328753-qwdxgk4z 131 28 in in IN cord-328753-qwdxgk4z 131 29 Asia Asia NNP cord-328753-qwdxgk4z 131 30 and and CC cord-328753-qwdxgk4z 131 31 Africa Africa NNP cord-328753-qwdxgk4z 131 32 [ [ -LRB- cord-328753-qwdxgk4z 131 33 73 73 CD cord-328753-qwdxgk4z 131 34 , , , cord-328753-qwdxgk4z 131 35 74 74 CD cord-328753-qwdxgk4z 131 36 ] ] -RRB- cord-328753-qwdxgk4z 131 37 . . . cord-328753-qwdxgk4z 132 1 The the DT cord-328753-qwdxgk4z 132 2 vaccine vaccine NN cord-328753-qwdxgk4z 132 3 is be VBZ cord-328753-qwdxgk4z 132 4 mostly mostly RB cord-328753-qwdxgk4z 132 5 used use VBN cord-328753-qwdxgk4z 132 6 therapeutically therapeutically RB cord-328753-qwdxgk4z 132 7 as as IN cord-328753-qwdxgk4z 132 8 a a DT cord-328753-qwdxgk4z 132 9 post post JJ cord-328753-qwdxgk4z 132 10 - - JJ cord-328753-qwdxgk4z 132 11 exposure exposure JJ cord-328753-qwdxgk4z 132 12 treatment treatment NN cord-328753-qwdxgk4z 132 13 . . . cord-328753-qwdxgk4z 133 1 For for IN cord-328753-qwdxgk4z 133 2 infection infection NN cord-328753-qwdxgk4z 133 3 combined combine VBN cord-328753-qwdxgk4z 133 4 with with IN cord-328753-qwdxgk4z 133 5 a a DT cord-328753-qwdxgk4z 133 6 seriously seriously RB cord-328753-qwdxgk4z 133 7 bleeding bleeding JJ cord-328753-qwdxgk4z 133 8 injury injury NN cord-328753-qwdxgk4z 133 9 , , , cord-328753-qwdxgk4z 133 10 the the DT cord-328753-qwdxgk4z 133 11 WHO who WP cord-328753-qwdxgk4z 133 12 recommends recommend VBZ cord-328753-qwdxgk4z 133 13 complementing complement VBG cord-328753-qwdxgk4z 133 14 vaccination vaccination NN cord-328753-qwdxgk4z 133 15 with with IN cord-328753-qwdxgk4z 133 16 local local JJ cord-328753-qwdxgk4z 133 17 instillation instillation NN cord-328753-qwdxgk4z 133 18 of of IN cord-328753-qwdxgk4z 133 19 human human JJ cord-328753-qwdxgk4z 133 20 or or CC cord-328753-qwdxgk4z 133 21 equine equine JJ cord-328753-qwdxgk4z 133 22 rabies rabies NN cord-328753-qwdxgk4z 133 23 immunoglobulins immunoglobulin NNS cord-328753-qwdxgk4z 133 24 ( ( -LRB- cord-328753-qwdxgk4z 133 25 RIG rig NN cord-328753-qwdxgk4z 133 26 ) ) -RRB- cord-328753-qwdxgk4z 133 27 to to TO cord-328753-qwdxgk4z 133 28 neutralize neutralize VB cord-328753-qwdxgk4z 133 29 the the DT cord-328753-qwdxgk4z 133 30 RABV RABV NNP cord-328753-qwdxgk4z 133 31 load load NN cord-328753-qwdxgk4z 133 32 in in IN cord-328753-qwdxgk4z 133 33 situ situ NN cord-328753-qwdxgk4z 133 34 . . . cord-328753-qwdxgk4z 134 1 There there EX cord-328753-qwdxgk4z 134 2 is be VBZ cord-328753-qwdxgk4z 134 3 currently currently RB cord-328753-qwdxgk4z 134 4 a a DT cord-328753-qwdxgk4z 134 5 critical critical JJ cord-328753-qwdxgk4z 134 6 shortage shortage NN cord-328753-qwdxgk4z 134 7 worldwide worldwide RB cord-328753-qwdxgk4z 134 8 and and CC cord-328753-qwdxgk4z 134 9 the the DT cord-328753-qwdxgk4z 134 10 WHO who WP cord-328753-qwdxgk4z 134 11 is be VBZ cord-328753-qwdxgk4z 134 12 exploring explore VBG cord-328753-qwdxgk4z 134 13 alternative alternative JJ cord-328753-qwdxgk4z 134 14 approaches approach NNS cord-328753-qwdxgk4z 134 15 , , , cord-328753-qwdxgk4z 134 16 such such JJ cord-328753-qwdxgk4z 134 17 as as IN cord-328753-qwdxgk4z 134 18 cocktails cocktail NNS cord-328753-qwdxgk4z 134 19 of of IN cord-328753-qwdxgk4z 134 20 human human JJ cord-328753-qwdxgk4z 134 21 or or CC cord-328753-qwdxgk4z 134 22 humanized humanize VBN cord-328753-qwdxgk4z 134 23 neutralizing neutralize VBG cord-328753-qwdxgk4z 134 24 mAbs mAbs NNP cord-328753-qwdxgk4z 134 25 [ [ -LRB- cord-328753-qwdxgk4z 134 26 75 75 CD cord-328753-qwdxgk4z 134 27 ] ] -RRB- cord-328753-qwdxgk4z 134 28 . . . cord-328753-qwdxgk4z 135 1 Neutralizing neutralize VBG cord-328753-qwdxgk4z 135 2 anti anti JJ cord-328753-qwdxgk4z 135 3 - - JJ cord-328753-qwdxgk4z 135 4 RABV rabv JJ cord-328753-qwdxgk4z 135 5 VHHs vhh NNS cord-328753-qwdxgk4z 135 6 directed direct VBN cord-328753-qwdxgk4z 135 7 against against IN cord-328753-qwdxgk4z 135 8 glycoproteins glycoprotein NNS cord-328753-qwdxgk4z 135 9 have have VBP cord-328753-qwdxgk4z 135 10 been be VBN cord-328753-qwdxgk4z 135 11 raised raise VBN cord-328753-qwdxgk4z 135 12 from from IN cord-328753-qwdxgk4z 135 13 a a DT cord-328753-qwdxgk4z 135 14 VHH VHH NNP cord-328753-qwdxgk4z 135 15 phage phage NN cord-328753-qwdxgk4z 135 16 library library NN cord-328753-qwdxgk4z 135 17 generated generate VBN cord-328753-qwdxgk4z 135 18 from from IN cord-328753-qwdxgk4z 135 19 the the DT cord-328753-qwdxgk4z 135 20 immunization immunization NN cord-328753-qwdxgk4z 135 21 of of IN cord-328753-qwdxgk4z 135 22 a a DT cord-328753-qwdxgk4z 135 23 llama llama NN cord-328753-qwdxgk4z 135 24 with with IN cord-328753-qwdxgk4z 135 25 inactivated inactivate VBN cord-328753-qwdxgk4z 135 26 rabies rabie NNS cord-328753-qwdxgk4z 135 27 vaccine vaccine NN cord-328753-qwdxgk4z 135 28 ( ( -LRB- cord-328753-qwdxgk4z 135 29 genotype genotype NNP cord-328753-qwdxgk4z 135 30 1 1 CD cord-328753-qwdxgk4z 135 31 , , , cord-328753-qwdxgk4z 135 32 Sanofi Sanofi NNP cord-328753-qwdxgk4z 135 33 Pasteur Pasteur NNP cord-328753-qwdxgk4z 135 34 MSD MSD NNP cord-328753-qwdxgk4z 135 35 ) ) -RRB- cord-328753-qwdxgk4z 135 36 [ [ -LRB- cord-328753-qwdxgk4z 135 37 71 71 CD cord-328753-qwdxgk4z 135 38 ] ] -RRB- cord-328753-qwdxgk4z 135 39 . . . cord-328753-qwdxgk4z 136 1 The the DT cord-328753-qwdxgk4z 136 2 IC IC NNP cord-328753-qwdxgk4z 136 3 50 50 CD cord-328753-qwdxgk4z 136 4 s s NNS cord-328753-qwdxgk4z 136 5 of of IN cord-328753-qwdxgk4z 136 6 the the DT cord-328753-qwdxgk4z 136 7 CVS-11 CVS-11 NNP cord-328753-qwdxgk4z 136 8 ( ( -LRB- cord-328753-qwdxgk4z 136 9 genotype genotype NN cord-328753-qwdxgk4z 136 10 1 1 CD cord-328753-qwdxgk4z 136 11 ) ) -RRB- cord-328753-qwdxgk4z 136 12 strain strain NN cord-328753-qwdxgk4z 136 13 ranged range VBD cord-328753-qwdxgk4z 136 14 from from IN cord-328753-qwdxgk4z 136 15 7 7 CD cord-328753-qwdxgk4z 136 16 to to IN cord-328753-qwdxgk4z 136 17 325 325 CD cord-328753-qwdxgk4z 136 18 nM. nm. NN cord-328753-qwdxgk4z 137 1 These these DT cord-328753-qwdxgk4z 137 2 VHHs vhh NNS cord-328753-qwdxgk4z 137 3 were be VBD cord-328753-qwdxgk4z 137 4 fused fuse VBN cord-328753-qwdxgk4z 137 5 to to IN cord-328753-qwdxgk4z 137 6 an an DT cord-328753-qwdxgk4z 137 7 anti anti JJ cord-328753-qwdxgk4z 137 8 - - JJ cord-328753-qwdxgk4z 137 9 albumin albumin JJ cord-328753-qwdxgk4z 137 10 VHH vhh NN cord-328753-qwdxgk4z 137 11 to to TO cord-328753-qwdxgk4z 137 12 extend extend VB cord-328753-qwdxgk4z 137 13 its -PRON- PRP$ cord-328753-qwdxgk4z 137 14 serum serum NN cord-328753-qwdxgk4z 137 15 half half JJ cord-328753-qwdxgk4z 137 16 - - HYPH cord-328753-qwdxgk4z 137 17 life life NN cord-328753-qwdxgk4z 137 18 and and CC cord-328753-qwdxgk4z 137 19 were be VBD cord-328753-qwdxgk4z 137 20 able able JJ cord-328753-qwdxgk4z 137 21 to to TO cord-328753-qwdxgk4z 137 22 neutralize neutralize VB cord-328753-qwdxgk4z 137 23 the the DT cord-328753-qwdxgk4z 137 24 virus virus NN cord-328753-qwdxgk4z 137 25 at at IN cord-328753-qwdxgk4z 137 26 picomolar picomolar JJ cord-328753-qwdxgk4z 137 27 doses dose NNS cord-328753-qwdxgk4z 137 28 [ [ -LRB- cord-328753-qwdxgk4z 137 29 76 76 CD cord-328753-qwdxgk4z 137 30 ] ] -RRB- cord-328753-qwdxgk4z 137 31 . . . cord-328753-qwdxgk4z 138 1 A a DT cord-328753-qwdxgk4z 138 2 combined combine VBN cord-328753-qwdxgk4z 138 3 treatment treatment NN cord-328753-qwdxgk4z 138 4 based base VBN cord-328753-qwdxgk4z 138 5 on on IN cord-328753-qwdxgk4z 138 6 VHH vhh NN cord-328753-qwdxgk4z 138 7 and and CC cord-328753-qwdxgk4z 138 8 vaccine vaccine NN cord-328753-qwdxgk4z 138 9 ( ( -LRB- cord-328753-qwdxgk4z 138 10 Rabipur Rabipur NNP cord-328753-qwdxgk4z 138 11 , , , cord-328753-qwdxgk4z 138 12 Novartis Novartis NNP cord-328753-qwdxgk4z 138 13 ) ) -RRB- cord-328753-qwdxgk4z 138 14 acted act VBD cord-328753-qwdxgk4z 138 15 synergistically synergistically RB cord-328753-qwdxgk4z 138 16 to to TO cord-328753-qwdxgk4z 138 17 protect protect VB cord-328753-qwdxgk4z 138 18 mice mouse NNS cord-328753-qwdxgk4z 138 19 in in IN cord-328753-qwdxgk4z 138 20 an an DT cord-328753-qwdxgk4z 138 21 intranasal intranasal NN cord-328753-qwdxgk4z 138 22 rabies rabies NN cord-328753-qwdxgk4z 138 23 infection infection NN cord-328753-qwdxgk4z 138 24 model model NN cord-328753-qwdxgk4z 138 25 [ [ -LRB- cord-328753-qwdxgk4z 138 26 77 77 CD cord-328753-qwdxgk4z 138 27 ] ] -RRB- cord-328753-qwdxgk4z 138 28 . . . cord-328753-qwdxgk4z 139 1 However however RB cord-328753-qwdxgk4z 139 2 , , , cord-328753-qwdxgk4z 139 3 the the DT cord-328753-qwdxgk4z 139 4 principal principal JJ cord-328753-qwdxgk4z 139 5 difficulty difficulty NN cord-328753-qwdxgk4z 139 6 of of IN cord-328753-qwdxgk4z 139 7 an an DT cord-328753-qwdxgk4z 139 8 antiviral antiviral JJ cord-328753-qwdxgk4z 139 9 approach approach NN cord-328753-qwdxgk4z 139 10 against against IN cord-328753-qwdxgk4z 139 11 rabies rabies NN cord-328753-qwdxgk4z 139 12 resides reside VBZ cord-328753-qwdxgk4z 139 13 in in IN cord-328753-qwdxgk4z 139 14 the the DT cord-328753-qwdxgk4z 139 15 specific specific JJ cord-328753-qwdxgk4z 139 16 neurotropism neurotropism NN cord-328753-qwdxgk4z 139 17 of of IN cord-328753-qwdxgk4z 139 18 RABV RABV NNP cord-328753-qwdxgk4z 139 19 , , , cord-328753-qwdxgk4z 139 20 which which WDT cord-328753-qwdxgk4z 139 21 makes make VBZ cord-328753-qwdxgk4z 139 22 it -PRON- PRP cord-328753-qwdxgk4z 139 23 not not RB cord-328753-qwdxgk4z 139 24 readily readily RB cord-328753-qwdxgk4z 139 25 accessible accessible JJ cord-328753-qwdxgk4z 139 26 once once IN cord-328753-qwdxgk4z 139 27 it -PRON- PRP cord-328753-qwdxgk4z 139 28 has have VBZ cord-328753-qwdxgk4z 139 29 accessed access VBN cord-328753-qwdxgk4z 139 30 the the DT cord-328753-qwdxgk4z 139 31 CNS CNS NNP cord-328753-qwdxgk4z 139 32 . . . cord-328753-qwdxgk4z 140 1 At at IN cord-328753-qwdxgk4z 140 2 this this DT cord-328753-qwdxgk4z 140 3 stage stage NN cord-328753-qwdxgk4z 140 4 , , , cord-328753-qwdxgk4z 140 5 only only RB cord-328753-qwdxgk4z 140 6 molecules molecule NNS cord-328753-qwdxgk4z 140 7 capable capable JJ cord-328753-qwdxgk4z 140 8 of of IN cord-328753-qwdxgk4z 140 9 crossing cross VBG cord-328753-qwdxgk4z 140 10 the the DT cord-328753-qwdxgk4z 140 11 blood blood NN cord-328753-qwdxgk4z 140 12 brain brain NN cord-328753-qwdxgk4z 140 13 barrier barrier NN cord-328753-qwdxgk4z 140 14 and and CC cord-328753-qwdxgk4z 140 15 penetrating penetrate VBG cord-328753-qwdxgk4z 140 16 into into IN cord-328753-qwdxgk4z 140 17 neurons neuron NNS cord-328753-qwdxgk4z 140 18 would would MD cord-328753-qwdxgk4z 140 19 be be VB cord-328753-qwdxgk4z 140 20 able able JJ cord-328753-qwdxgk4z 140 21 to to TO cord-328753-qwdxgk4z 140 22 inhibit inhibit VB cord-328753-qwdxgk4z 140 23 the the DT cord-328753-qwdxgk4z 140 24 infection infection NN cord-328753-qwdxgk4z 140 25 . . . cord-328753-qwdxgk4z 141 1 Foot foot NN cord-328753-qwdxgk4z 141 2 - - HYPH cord-328753-qwdxgk4z 141 3 and and CC cord-328753-qwdxgk4z 141 4 - - HYPH cord-328753-qwdxgk4z 141 5 mouth mouth NN cord-328753-qwdxgk4z 141 6 disease disease NN cord-328753-qwdxgk4z 141 7 ( ( -LRB- cord-328753-qwdxgk4z 141 8 FMD FMD NNP cord-328753-qwdxgk4z 141 9 ) ) -RRB- cord-328753-qwdxgk4z 141 10 is be VBZ cord-328753-qwdxgk4z 141 11 a a DT cord-328753-qwdxgk4z 141 12 contagious contagious JJ cord-328753-qwdxgk4z 141 13 viral viral JJ cord-328753-qwdxgk4z 141 14 disease disease NN cord-328753-qwdxgk4z 141 15 that that WDT cord-328753-qwdxgk4z 141 16 affects affect VBZ cord-328753-qwdxgk4z 141 17 cattle cattle NNS cord-328753-qwdxgk4z 141 18 , , , cord-328753-qwdxgk4z 141 19 swine swine NN cord-328753-qwdxgk4z 141 20 , , , cord-328753-qwdxgk4z 141 21 sheep sheep NN cord-328753-qwdxgk4z 141 22 , , , cord-328753-qwdxgk4z 141 23 and and CC cord-328753-qwdxgk4z 141 24 approximately approximately RB cord-328753-qwdxgk4z 141 25 70 70 CD cord-328753-qwdxgk4z 141 26 wildlife wildlife NN cord-328753-qwdxgk4z 141 27 species specie NNS cord-328753-qwdxgk4z 141 28 ( ( -LRB- cord-328753-qwdxgk4z 141 29 including include VBG cord-328753-qwdxgk4z 141 30 llama llama NN cord-328753-qwdxgk4z 141 31 and and CC cord-328753-qwdxgk4z 141 32 camel camel NN cord-328753-qwdxgk4z 141 33 ) ) -RRB- cord-328753-qwdxgk4z 141 34 , , , cord-328753-qwdxgk4z 141 35 with with IN cord-328753-qwdxgk4z 141 36 a a DT cord-328753-qwdxgk4z 141 37 potential potential NN cord-328753-qwdxgk4z 141 38 for for IN cord-328753-qwdxgk4z 141 39 rapid rapid JJ cord-328753-qwdxgk4z 141 40 spread spread NN cord-328753-qwdxgk4z 141 41 between between IN cord-328753-qwdxgk4z 141 42 susceptible susceptible JJ cord-328753-qwdxgk4z 141 43 animals animal NNS cord-328753-qwdxgk4z 141 44 . . . cord-328753-qwdxgk4z 142 1 The the DT cord-328753-qwdxgk4z 142 2 disease disease NN cord-328753-qwdxgk4z 142 3 has have VBZ cord-328753-qwdxgk4z 142 4 been be VBN cord-328753-qwdxgk4z 142 5 identified identify VBN cord-328753-qwdxgk4z 142 6 worldwide worldwide RB cord-328753-qwdxgk4z 142 7 whereever whereever WRB cord-328753-qwdxgk4z 142 8 livestock livestock NN cord-328753-qwdxgk4z 142 9 are be VBP cord-328753-qwdxgk4z 142 10 raised raise VBN cord-328753-qwdxgk4z 142 11 . . . cord-328753-qwdxgk4z 143 1 In in IN cord-328753-qwdxgk4z 143 2 the the DT cord-328753-qwdxgk4z 143 3 last last JJ cord-328753-qwdxgk4z 143 4 20 20 CD cord-328753-qwdxgk4z 143 5 years year NNS cord-328753-qwdxgk4z 143 6 , , , cord-328753-qwdxgk4z 143 7 there there EX cord-328753-qwdxgk4z 143 8 have have VBP cord-328753-qwdxgk4z 143 9 been be VBN cord-328753-qwdxgk4z 143 10 massive massive JJ cord-328753-qwdxgk4z 143 11 outbreaks outbreak NNS cord-328753-qwdxgk4z 143 12 of of IN cord-328753-qwdxgk4z 143 13 FMD FMD NNP cord-328753-qwdxgk4z 143 14 in in IN cord-328753-qwdxgk4z 143 15 countries country NNS cord-328753-qwdxgk4z 143 16 formerly formerly RB cord-328753-qwdxgk4z 143 17 free free JJ cord-328753-qwdxgk4z 143 18 of of IN cord-328753-qwdxgk4z 143 19 the the DT cord-328753-qwdxgk4z 143 20 disease disease NN cord-328753-qwdxgk4z 143 21 , , , cord-328753-qwdxgk4z 143 22 such such JJ cord-328753-qwdxgk4z 143 23 as as IN cord-328753-qwdxgk4z 143 24 the the DT cord-328753-qwdxgk4z 143 25 United United NNP cord-328753-qwdxgk4z 143 26 Kingdom Kingdom NNP cord-328753-qwdxgk4z 143 27 in in IN cord-328753-qwdxgk4z 143 28 2001 2001 CD cord-328753-qwdxgk4z 143 29 [ [ -LRB- cord-328753-qwdxgk4z 143 30 78 78 CD cord-328753-qwdxgk4z 143 31 ] ] -RRB- cord-328753-qwdxgk4z 143 32 and and CC cord-328753-qwdxgk4z 143 33 Taiwan Taiwan NNP cord-328753-qwdxgk4z 143 34 in in IN cord-328753-qwdxgk4z 143 35 1997 1997 CD cord-328753-qwdxgk4z 143 36 [ [ -LRB- cord-328753-qwdxgk4z 143 37 79 79 CD cord-328753-qwdxgk4z 143 38 ] ] -RRB- cord-328753-qwdxgk4z 143 39 . . . cord-328753-qwdxgk4z 144 1 Seven seven CD cord-328753-qwdxgk4z 144 2 antigenically antigenically RB cord-328753-qwdxgk4z 144 3 distinct distinct JJ cord-328753-qwdxgk4z 144 4 serotypes serotype NNS cord-328753-qwdxgk4z 144 5 of of IN cord-328753-qwdxgk4z 144 6 FMD FMD NNP cord-328753-qwdxgk4z 144 7 viruses virus NNS cord-328753-qwdxgk4z 144 8 have have VBP cord-328753-qwdxgk4z 144 9 been be VBN cord-328753-qwdxgk4z 144 10 identified identify VBN cord-328753-qwdxgk4z 144 11 : : : cord-328753-qwdxgk4z 144 12 O o UH cord-328753-qwdxgk4z 144 13 , , , cord-328753-qwdxgk4z 144 14 A A NNP cord-328753-qwdxgk4z 144 15 , , , cord-328753-qwdxgk4z 144 16 C C NNP cord-328753-qwdxgk4z 144 17 , , , cord-328753-qwdxgk4z 144 18 Asia Asia NNP cord-328753-qwdxgk4z 144 19 1 1 CD cord-328753-qwdxgk4z 144 20 , , , cord-328753-qwdxgk4z 144 21 SAT1 SAT1 NNP cord-328753-qwdxgk4z 144 22 , , , cord-328753-qwdxgk4z 144 23 SAT2 SAT2 NNP cord-328753-qwdxgk4z 144 24 , , , cord-328753-qwdxgk4z 144 25 and and CC cord-328753-qwdxgk4z 144 26 SAT3 SAT3 NNP cord-328753-qwdxgk4z 144 27 [ [ -LRB- cord-328753-qwdxgk4z 144 28 80 80 CD cord-328753-qwdxgk4z 144 29 ] ] -RRB- cord-328753-qwdxgk4z 144 30 . . . cord-328753-qwdxgk4z 145 1 Emergency emergency NN cord-328753-qwdxgk4z 145 2 vaccination vaccination NN cord-328753-qwdxgk4z 145 3 can can MD cord-328753-qwdxgk4z 145 4 be be VB cord-328753-qwdxgk4z 145 5 used use VBN cord-328753-qwdxgk4z 145 6 as as IN cord-328753-qwdxgk4z 145 7 an an DT cord-328753-qwdxgk4z 145 8 effective effective JJ cord-328753-qwdxgk4z 145 9 control control NN cord-328753-qwdxgk4z 145 10 measure measure NN cord-328753-qwdxgk4z 145 11 for for IN cord-328753-qwdxgk4z 145 12 FMD FMD NNP cord-328753-qwdxgk4z 145 13 outbreaks outbreak NNS cord-328753-qwdxgk4z 145 14 in in IN cord-328753-qwdxgk4z 145 15 FMD fmd NN cord-328753-qwdxgk4z 145 16 - - HYPH cord-328753-qwdxgk4z 145 17 free free JJ cord-328753-qwdxgk4z 145 18 regions region NNS cord-328753-qwdxgk4z 145 19 , , , cord-328753-qwdxgk4z 145 20 such such JJ cord-328753-qwdxgk4z 145 21 as as IN cord-328753-qwdxgk4z 145 22 the the DT cord-328753-qwdxgk4z 145 23 European European NNP cord-328753-qwdxgk4z 145 24 Union Union NNP cord-328753-qwdxgk4z 145 25 , , , cord-328753-qwdxgk4z 145 26 but but CC cord-328753-qwdxgk4z 145 27 the the DT cord-328753-qwdxgk4z 145 28 development development NN cord-328753-qwdxgk4z 145 29 of of IN cord-328753-qwdxgk4z 145 30 novel novel JJ cord-328753-qwdxgk4z 145 31 antiviral antiviral JJ cord-328753-qwdxgk4z 145 32 therapies therapy NNS cord-328753-qwdxgk4z 145 33 that that WDT cord-328753-qwdxgk4z 145 34 confer confer VBP cord-328753-qwdxgk4z 145 35 rapid rapid JJ cord-328753-qwdxgk4z 145 36 protection protection NN cord-328753-qwdxgk4z 145 37 against against IN cord-328753-qwdxgk4z 145 38 FMD FMD NNP cord-328753-qwdxgk4z 145 39 is be VBZ cord-328753-qwdxgk4z 145 40 still still RB cord-328753-qwdxgk4z 145 41 needed need VBN cord-328753-qwdxgk4z 145 42 . . . cord-328753-qwdxgk4z 146 1 Moreover moreover RB cord-328753-qwdxgk4z 146 2 , , , cord-328753-qwdxgk4z 146 3 it -PRON- PRP cord-328753-qwdxgk4z 146 4 is be VBZ cord-328753-qwdxgk4z 146 5 important important JJ cord-328753-qwdxgk4z 146 6 to to TO cord-328753-qwdxgk4z 146 7 develop develop VB cord-328753-qwdxgk4z 146 8 a a DT cord-328753-qwdxgk4z 146 9 rapid rapid JJ cord-328753-qwdxgk4z 146 10 diagnostic diagnostic JJ cord-328753-qwdxgk4z 146 11 test test NN cord-328753-qwdxgk4z 146 12 for for IN cord-328753-qwdxgk4z 146 13 identification identification NN cord-328753-qwdxgk4z 146 14 of of IN cord-328753-qwdxgk4z 146 15 the the DT cord-328753-qwdxgk4z 146 16 various various JJ cord-328753-qwdxgk4z 146 17 serotypes serotype NNS cord-328753-qwdxgk4z 146 18 of of IN cord-328753-qwdxgk4z 146 19 the the DT cord-328753-qwdxgk4z 146 20 viruses virus NNS cord-328753-qwdxgk4z 146 21 involved involve VBN cord-328753-qwdxgk4z 146 22 in in IN cord-328753-qwdxgk4z 146 23 FMD FMD NNP cord-328753-qwdxgk4z 146 24 outbreaks outbreak NNS cord-328753-qwdxgk4z 146 25 . . . cord-328753-qwdxgk4z 147 1 VHHs VHHs NNP cord-328753-qwdxgk4z 147 2 directed direct VBN cord-328753-qwdxgk4z 147 3 against against IN cord-328753-qwdxgk4z 147 4 serotype serotype NN cord-328753-qwdxgk4z 147 5 O o UH cord-328753-qwdxgk4z 147 6 have have VBP cord-328753-qwdxgk4z 147 7 been be VBN cord-328753-qwdxgk4z 147 8 raised raise VBN cord-328753-qwdxgk4z 147 9 . . . cord-328753-qwdxgk4z 148 1 They -PRON- PRP cord-328753-qwdxgk4z 148 2 have have VBP cord-328753-qwdxgk4z 148 3 provided provide VBN cord-328753-qwdxgk4z 148 4 only only RB cord-328753-qwdxgk4z 148 5 limited limited JJ cord-328753-qwdxgk4z 148 6 protection protection NN cord-328753-qwdxgk4z 148 7 to to IN cord-328753-qwdxgk4z 148 8 pigs pig NNS cord-328753-qwdxgk4z 148 9 . . . cord-328753-qwdxgk4z 149 1 Trimers trimer NNS cord-328753-qwdxgk4z 149 2 consisting consist VBG cord-328753-qwdxgk4z 149 3 of of IN cord-328753-qwdxgk4z 149 4 two two CD cord-328753-qwdxgk4z 149 5 VHHs vhh NNS cord-328753-qwdxgk4z 149 6 specific specific JJ cord-328753-qwdxgk4z 149 7 for for IN cord-328753-qwdxgk4z 149 8 FMDV FMDV NNP cord-328753-qwdxgk4z 149 9 and and CC cord-328753-qwdxgk4z 149 10 one one CD cord-328753-qwdxgk4z 149 11 VHH vhh NN cord-328753-qwdxgk4z 149 12 specific specific JJ cord-328753-qwdxgk4z 149 13 for for IN cord-328753-qwdxgk4z 149 14 porcine porcine JJ cord-328753-qwdxgk4z 149 15 Ig Ig NNS cord-328753-qwdxgk4z 149 16 have have VBP cord-328753-qwdxgk4z 149 17 been be VBN cord-328753-qwdxgk4z 149 18 constructed construct VBN cord-328753-qwdxgk4z 149 19 to to TO cord-328753-qwdxgk4z 149 20 increase increase VB cord-328753-qwdxgk4z 149 21 their -PRON- PRP$ cord-328753-qwdxgk4z 149 22 potency potency NN cord-328753-qwdxgk4z 149 23 and and CC cord-328753-qwdxgk4z 149 24 half half JJ cord-328753-qwdxgk4z 149 25 - - HYPH cord-328753-qwdxgk4z 149 26 life life NN cord-328753-qwdxgk4z 149 27 . . . cord-328753-qwdxgk4z 150 1 These these DT cord-328753-qwdxgk4z 150 2 trimers trimer NNS cord-328753-qwdxgk4z 150 3 provided provide VBD cord-328753-qwdxgk4z 150 4 better well JJR cord-328753-qwdxgk4z 150 5 protection protection NN cord-328753-qwdxgk4z 150 6 to to IN cord-328753-qwdxgk4z 150 7 pigs pig NNS cord-328753-qwdxgk4z 150 8 and and CC cord-328753-qwdxgk4z 150 9 delayed delay VBN cord-328753-qwdxgk4z 150 10 FMD fmd NN cord-328753-qwdxgk4z 150 11 transmission transmission NN cord-328753-qwdxgk4z 150 12 [ [ -LRB- cord-328753-qwdxgk4z 150 13 81 81 CD cord-328753-qwdxgk4z 150 14 ] ] -RRB- cord-328753-qwdxgk4z 150 15 . . . cord-328753-qwdxgk4z 151 1 Specific specific JJ cord-328753-qwdxgk4z 151 2 VHHs vhh NNS cord-328753-qwdxgk4z 151 3 raised raise VBD cord-328753-qwdxgk4z 151 4 against against IN cord-328753-qwdxgk4z 151 5 FMD FMD NNP cord-328753-qwdxgk4z 151 6 Asia Asia NNP cord-328753-qwdxgk4z 151 7 1 1 CD cord-328753-qwdxgk4z 151 8 virus virus NN cord-328753-qwdxgk4z 151 9 have have VBP cord-328753-qwdxgk4z 151 10 also also RB cord-328753-qwdxgk4z 151 11 been be VBN cord-328753-qwdxgk4z 151 12 obtained obtain VBN cord-328753-qwdxgk4z 151 13 . . . cord-328753-qwdxgk4z 152 1 They -PRON- PRP cord-328753-qwdxgk4z 152 2 have have VBP cord-328753-qwdxgk4z 152 3 been be VBN cord-328753-qwdxgk4z 152 4 used use VBN cord-328753-qwdxgk4z 152 5 to to TO cord-328753-qwdxgk4z 152 6 develop develop VB cord-328753-qwdxgk4z 152 7 diagnostic diagnostic JJ cord-328753-qwdxgk4z 152 8 assays assay NNS cord-328753-qwdxgk4z 152 9 by by IN cord-328753-qwdxgk4z 152 10 conjugating conjugate VBG cord-328753-qwdxgk4z 152 11 them -PRON- PRP cord-328753-qwdxgk4z 152 12 to to IN cord-328753-qwdxgk4z 152 13 either either CC cord-328753-qwdxgk4z 152 14 quantum quantum NN cord-328753-qwdxgk4z 152 15 dots dot NNS cord-328753-qwdxgk4z 152 16 [ [ -LRB- cord-328753-qwdxgk4z 152 17 82 82 CD cord-328753-qwdxgk4z 152 18 ] ] -RRB- cord-328753-qwdxgk4z 152 19 or or CC cord-328753-qwdxgk4z 152 20 carboxyl carboxyl NN cord-328753-qwdxgk4z 152 21 - - HYPH cord-328753-qwdxgk4z 152 22 magnetic magnetic JJ cord-328753-qwdxgk4z 152 23 beads bead NNS cord-328753-qwdxgk4z 152 24 [ [ -LRB- cord-328753-qwdxgk4z 152 25 83 83 CD cord-328753-qwdxgk4z 152 26 ] ] -RRB- cord-328753-qwdxgk4z 152 27 . . . cord-328753-qwdxgk4z 153 1 In in IN cord-328753-qwdxgk4z 153 2 this this DT cord-328753-qwdxgk4z 153 3 review review NN cord-328753-qwdxgk4z 153 4 , , , cord-328753-qwdxgk4z 153 5 we -PRON- PRP cord-328753-qwdxgk4z 153 6 provide provide VBP cord-328753-qwdxgk4z 153 7 evidence evidence NN cord-328753-qwdxgk4z 153 8 for for IN cord-328753-qwdxgk4z 153 9 the the DT cord-328753-qwdxgk4z 153 10 possible possible JJ cord-328753-qwdxgk4z 153 11 use use NN cord-328753-qwdxgk4z 153 12 of of IN cord-328753-qwdxgk4z 153 13 VHHs vhh NNS cord-328753-qwdxgk4z 153 14 as as IN cord-328753-qwdxgk4z 153 15 valuable valuable JJ cord-328753-qwdxgk4z 153 16 biomolecules biomolecule NNS cord-328753-qwdxgk4z 153 17 for for IN cord-328753-qwdxgk4z 153 18 the the DT cord-328753-qwdxgk4z 153 19 diagnosis diagnosis NN cord-328753-qwdxgk4z 153 20 and and CC cord-328753-qwdxgk4z 153 21 treatment treatment NN cord-328753-qwdxgk4z 153 22 of of IN cord-328753-qwdxgk4z 153 23 ZDs zd NNS cord-328753-qwdxgk4z 153 24 , , , cord-328753-qwdxgk4z 153 25 including include VBG cord-328753-qwdxgk4z 153 26 bacterial bacterial JJ cord-328753-qwdxgk4z 153 27 , , , cord-328753-qwdxgk4z 153 28 parasitic parasitic JJ cord-328753-qwdxgk4z 153 29 , , , cord-328753-qwdxgk4z 153 30 and and CC cord-328753-qwdxgk4z 153 31 viral viral JJ cord-328753-qwdxgk4z 153 32 zoonosis zoonosis NN cord-328753-qwdxgk4z 153 33 . . . cord-328753-qwdxgk4z 154 1 VHHs vhh NNS cord-328753-qwdxgk4z 154 2 provide provide VBP cord-328753-qwdxgk4z 154 3 many many JJ cord-328753-qwdxgk4z 154 4 advantages advantage NNS cord-328753-qwdxgk4z 154 5 over over IN cord-328753-qwdxgk4z 154 6 conventional conventional JJ cord-328753-qwdxgk4z 154 7 antibodies antibody NNS cord-328753-qwdxgk4z 154 8 and and CC cord-328753-qwdxgk4z 154 9 currently currently RB cord-328753-qwdxgk4z 154 10 used use VBN cord-328753-qwdxgk4z 154 11 antibody antibody NN cord-328753-qwdxgk4z 154 12 based base VBN cord-328753-qwdxgk4z 154 13 fragments fragment NNS cord-328753-qwdxgk4z 154 14 . . . cord-328753-qwdxgk4z 155 1 The the DT cord-328753-qwdxgk4z 155 2 ease ease NN cord-328753-qwdxgk4z 155 3 of of IN cord-328753-qwdxgk4z 155 4 high high JJ cord-328753-qwdxgk4z 155 5 - - HYPH cord-328753-qwdxgk4z 155 6 level level NN cord-328753-qwdxgk4z 155 7 production production NN cord-328753-qwdxgk4z 155 8 , , , cord-328753-qwdxgk4z 155 9 small small JJ cord-328753-qwdxgk4z 155 10 size size NN cord-328753-qwdxgk4z 155 11 , , , cord-328753-qwdxgk4z 155 12 and and CC cord-328753-qwdxgk4z 155 13 high high JJ cord-328753-qwdxgk4z 155 14 stability stability NN cord-328753-qwdxgk4z 155 15 make make VBP cord-328753-qwdxgk4z 155 16 VHHs vhh NNS cord-328753-qwdxgk4z 155 17 extremely extremely RB cord-328753-qwdxgk4z 155 18 reliable reliable JJ cord-328753-qwdxgk4z 155 19 for for IN cord-328753-qwdxgk4z 155 20 genetic genetic JJ cord-328753-qwdxgk4z 155 21 and and CC cord-328753-qwdxgk4z 155 22 chemical chemical JJ cord-328753-qwdxgk4z 155 23 modification modification NN cord-328753-qwdxgk4z 155 24 , , , cord-328753-qwdxgk4z 155 25 such such JJ cord-328753-qwdxgk4z 155 26 as as IN cord-328753-qwdxgk4z 155 27 the the DT cord-328753-qwdxgk4z 155 28 production production NN cord-328753-qwdxgk4z 155 29 of of IN cord-328753-qwdxgk4z 155 30 VHH vhh NN cord-328753-qwdxgk4z 155 31 - - HYPH cord-328753-qwdxgk4z 155 32 based base VBN cord-328753-qwdxgk4z 155 33 fusion fusion NN cord-328753-qwdxgk4z 155 34 proteins protein NNS cord-328753-qwdxgk4z 155 35 to to TO cord-328753-qwdxgk4z 155 36 increase increase VB cord-328753-qwdxgk4z 155 37 the the DT cord-328753-qwdxgk4z 155 38 persistence persistence NN cord-328753-qwdxgk4z 155 39 of of IN cord-328753-qwdxgk4z 155 40 VHHs vhh NNS cord-328753-qwdxgk4z 155 41 in in IN cord-328753-qwdxgk4z 155 42 serum serum NN cord-328753-qwdxgk4z 155 43 or or CC cord-328753-qwdxgk4z 155 44 confer confer VB cord-328753-qwdxgk4z 155 45 additional additional JJ cord-328753-qwdxgk4z 155 46 functions function NNS cord-328753-qwdxgk4z 155 47 . . . cord-328753-qwdxgk4z 156 1 Construction construction NN cord-328753-qwdxgk4z 156 2 of of IN cord-328753-qwdxgk4z 156 3 multivalent multivalent JJ cord-328753-qwdxgk4z 156 4 VHHs vhh NNS cord-328753-qwdxgk4z 156 5 consisting consist VBG cord-328753-qwdxgk4z 156 6 of of IN cord-328753-qwdxgk4z 156 7 two two CD cord-328753-qwdxgk4z 156 8 or or CC cord-328753-qwdxgk4z 156 9 more more RBR cord-328753-qwdxgk4z 156 10 linked linked JJ cord-328753-qwdxgk4z 156 11 VHHs vhh NNS cord-328753-qwdxgk4z 156 12 targeting target VBG cord-328753-qwdxgk4z 156 13 various various JJ cord-328753-qwdxgk4z 156 14 epitopes epitope NNS cord-328753-qwdxgk4z 156 15 leads lead VBZ cord-328753-qwdxgk4z 156 16 to to IN cord-328753-qwdxgk4z 156 17 an an DT cord-328753-qwdxgk4z 156 18 increase increase NN cord-328753-qwdxgk4z 156 19 in in IN cord-328753-qwdxgk4z 156 20 their -PRON- PRP$ cord-328753-qwdxgk4z 156 21 ability ability NN cord-328753-qwdxgk4z 156 22 to to TO cord-328753-qwdxgk4z 156 23 neutralize neutralize VB cord-328753-qwdxgk4z 156 24 toxins toxin NNS cord-328753-qwdxgk4z 156 25 [ [ -LRB- cord-328753-qwdxgk4z 156 26 43 43 CD cord-328753-qwdxgk4z 156 27 , , , cord-328753-qwdxgk4z 156 28 44 44 CD cord-328753-qwdxgk4z 156 29 ] ] -RRB- cord-328753-qwdxgk4z 156 30 and and CC cord-328753-qwdxgk4z 156 31 viruses virus NNS cord-328753-qwdxgk4z 156 32 [ [ -LRB- cord-328753-qwdxgk4z 156 33 68 68 CD cord-328753-qwdxgk4z 156 34 , , , cord-328753-qwdxgk4z 156 35 72 72 CD cord-328753-qwdxgk4z 156 36 , , , cord-328753-qwdxgk4z 156 37 76 76 CD cord-328753-qwdxgk4z 156 38 , , , cord-328753-qwdxgk4z 156 39 81 81 CD cord-328753-qwdxgk4z 156 40 ] ] -RRB- cord-328753-qwdxgk4z 156 41 , , , cord-328753-qwdxgk4z 156 42 suggesting suggest VBG cord-328753-qwdxgk4z 156 43 the the DT cord-328753-qwdxgk4z 156 44 development development NN cord-328753-qwdxgk4z 156 45 of of IN cord-328753-qwdxgk4z 156 46 these these DT cord-328753-qwdxgk4z 156 47 approaches approach NNS cord-328753-qwdxgk4z 156 48 for for IN cord-328753-qwdxgk4z 156 49 VHHs vhh NNS cord-328753-qwdxgk4z 156 50 targeting target VBG cord-328753-qwdxgk4z 156 51 other other JJ cord-328753-qwdxgk4z 156 52 viruses virus NNS cord-328753-qwdxgk4z 156 53 not not RB cord-328753-qwdxgk4z 156 54 yet yet RB cord-328753-qwdxgk4z 156 55 tested test VBN cord-328753-qwdxgk4z 156 56 . . . cord-328753-qwdxgk4z 157 1 Presently presently RB cord-328753-qwdxgk4z 157 2 available available JJ cord-328753-qwdxgk4z 157 3 anti anti JJ cord-328753-qwdxgk4z 157 4 - - JJ cord-328753-qwdxgk4z 157 5 viral viral JJ cord-328753-qwdxgk4z 157 6 therapeutic therapeutic JJ cord-328753-qwdxgk4z 157 7 mAbs mAbs NNP cord-328753-qwdxgk4z 157 8 , , , cord-328753-qwdxgk4z 157 9 at at IN cord-328753-qwdxgk4z 157 10 various various JJ cord-328753-qwdxgk4z 157 11 stages stage NNS cord-328753-qwdxgk4z 157 12 of of IN cord-328753-qwdxgk4z 157 13 pre pre JJ cord-328753-qwdxgk4z 157 14 - - JJ cord-328753-qwdxgk4z 157 15 clinical clinical JJ cord-328753-qwdxgk4z 157 16 evaluation evaluation NN cord-328753-qwdxgk4z 157 17 , , , cord-328753-qwdxgk4z 157 18 mostly mostly RB cord-328753-qwdxgk4z 157 19 target target NN cord-328753-qwdxgk4z 157 20 surface surface NN cord-328753-qwdxgk4z 157 21 antigens antigen NNS cord-328753-qwdxgk4z 157 22 that that WDT cord-328753-qwdxgk4z 157 23 are be VBP cord-328753-qwdxgk4z 157 24 often often RB cord-328753-qwdxgk4z 157 25 diverse diverse JJ cord-328753-qwdxgk4z 157 26 or or CC cord-328753-qwdxgk4z 157 27 variable variable JJ cord-328753-qwdxgk4z 157 28 in in IN cord-328753-qwdxgk4z 157 29 sequence sequence NN cord-328753-qwdxgk4z 157 30 ( ( -LRB- cord-328753-qwdxgk4z 157 31 e.g. e.g. IN cord-328753-qwdxgk4z 157 32 HIV HIV NNP cord-328753-qwdxgk4z 157 33 gp160 gp160 NNP cord-328753-qwdxgk4z 157 34 , , , cord-328753-qwdxgk4z 157 35 influenza influenza NN cord-328753-qwdxgk4z 157 36 HA HA NNP cord-328753-qwdxgk4z 157 37 ) ) -RRB- cord-328753-qwdxgk4z 158 1 : : : cord-328753-qwdxgk4z 158 2 their -PRON- PRP$ cord-328753-qwdxgk4z 158 3 efficiency efficiency NN cord-328753-qwdxgk4z 158 4 thus thus RB cord-328753-qwdxgk4z 158 5 requires require VBZ cord-328753-qwdxgk4z 158 6 challenging challenging JJ cord-328753-qwdxgk4z 158 7 protein protein NN cord-328753-qwdxgk4z 158 8 engineering engineering NN cord-328753-qwdxgk4z 158 9 efforts effort NNS cord-328753-qwdxgk4z 158 10 to to TO cord-328753-qwdxgk4z 158 11 obtain obtain VB cord-328753-qwdxgk4z 158 12 antibodies antibody NNS cord-328753-qwdxgk4z 158 13 that that WDT cord-328753-qwdxgk4z 158 14 are be VBP cord-328753-qwdxgk4z 158 15 either either CC cord-328753-qwdxgk4z 158 16 broadly broadly RB cord-328753-qwdxgk4z 158 17 neutralizing neutralize VBG cord-328753-qwdxgk4z 158 18 or or CC cord-328753-qwdxgk4z 158 19 robust robust JJ cord-328753-qwdxgk4z 158 20 against against IN cord-328753-qwdxgk4z 158 21 viral viral JJ cord-328753-qwdxgk4z 158 22 escape escape NN cord-328753-qwdxgk4z 158 23 through through IN cord-328753-qwdxgk4z 158 24 antigenic antigenic JJ cord-328753-qwdxgk4z 158 25 variation variation NN cord-328753-qwdxgk4z 158 26 ( ( -LRB- cord-328753-qwdxgk4z 158 27 drift drift NN cord-328753-qwdxgk4z 158 28 ) ) -RRB- cord-328753-qwdxgk4z 158 29 . . . cord-328753-qwdxgk4z 159 1 An an DT cord-328753-qwdxgk4z 159 2 alternative alternative NN cord-328753-qwdxgk4z 159 3 is be VBZ cord-328753-qwdxgk4z 159 4 the the DT cord-328753-qwdxgk4z 159 5 use use NN cord-328753-qwdxgk4z 159 6 of of IN cord-328753-qwdxgk4z 159 7 " " `` cord-328753-qwdxgk4z 159 8 broadly broadly RB cord-328753-qwdxgk4z 159 9 neutralizing neutralize VBG cord-328753-qwdxgk4z 159 10 antibodies antibody NNS cord-328753-qwdxgk4z 159 11 ( ( -LRB- cord-328753-qwdxgk4z 159 12 bNAb bNAb '' cord-328753-qwdxgk4z 159 13 ) ) -RRB- cord-328753-qwdxgk4z 159 14 " " '' cord-328753-qwdxgk4z 159 15 , , , cord-328753-qwdxgk4z 159 16 which which WDT cord-328753-qwdxgk4z 159 17 are be VBP cord-328753-qwdxgk4z 159 18 antibodies antibody NNS cord-328753-qwdxgk4z 159 19 found find VBN cord-328753-qwdxgk4z 159 20 in in IN cord-328753-qwdxgk4z 159 21 infected infected JJ cord-328753-qwdxgk4z 159 22 mammals mammal NNS cord-328753-qwdxgk4z 159 23 able able JJ cord-328753-qwdxgk4z 159 24 to to TO cord-328753-qwdxgk4z 159 25 neutralize neutralize VB cord-328753-qwdxgk4z 159 26 most most JJS cord-328753-qwdxgk4z 159 27 strains strain NNS cord-328753-qwdxgk4z 159 28 of of IN cord-328753-qwdxgk4z 159 29 a a DT cord-328753-qwdxgk4z 159 30 given give VBN cord-328753-qwdxgk4z 159 31 highly highly RB cord-328753-qwdxgk4z 159 32 antigenically antigenically RB cord-328753-qwdxgk4z 159 33 variable variable JJ cord-328753-qwdxgk4z 159 34 pathogen pathogen NN cord-328753-qwdxgk4z 159 35 . . . cord-328753-qwdxgk4z 160 1 bNAbs bnabs NN cord-328753-qwdxgk4z 160 2 have have VBP cord-328753-qwdxgk4z 160 3 been be VBN cord-328753-qwdxgk4z 160 4 isolated isolate VBN cord-328753-qwdxgk4z 160 5 from from IN cord-328753-qwdxgk4z 160 6 infected infected JJ cord-328753-qwdxgk4z 160 7 humans human NNS cord-328753-qwdxgk4z 160 8 against against IN cord-328753-qwdxgk4z 160 9 HIV HIV NNP cord-328753-qwdxgk4z 160 10 [ [ -LRB- cord-328753-qwdxgk4z 160 11 84 84 CD cord-328753-qwdxgk4z 160 12 ] ] -RRB- cord-328753-qwdxgk4z 160 13 , , , cord-328753-qwdxgk4z 160 14 influenza influenza NN cord-328753-qwdxgk4z 160 15 [ [ -LRB- cord-328753-qwdxgk4z 160 16 85 85 CD cord-328753-qwdxgk4z 160 17 ] ] -RRB- cord-328753-qwdxgk4z 160 18 , , , cord-328753-qwdxgk4z 160 19 and and CC cord-328753-qwdxgk4z 160 20 dengue dengue NN cord-328753-qwdxgk4z 160 21 viruses virus NNS cord-328753-qwdxgk4z 160 22 [ [ -LRB- cord-328753-qwdxgk4z 160 23 86 86 CD cord-328753-qwdxgk4z 160 24 ] ] -RRB- cord-328753-qwdxgk4z 160 25 . . . cord-328753-qwdxgk4z 161 1 Camelids Camelids NNP cord-328753-qwdxgk4z 161 2 could could MD cord-328753-qwdxgk4z 161 3 also also RB cord-328753-qwdxgk4z 161 4 be be VB cord-328753-qwdxgk4z 161 5 a a DT cord-328753-qwdxgk4z 161 6 source source NN cord-328753-qwdxgk4z 161 7 of of IN cord-328753-qwdxgk4z 161 8 bNAbs bnabs NN cord-328753-qwdxgk4z 161 9 . . . cord-328753-qwdxgk4z 162 1 Indeed indeed RB cord-328753-qwdxgk4z 162 2 antibodies antibody NNS cord-328753-qwdxgk4z 162 3 against against IN cord-328753-qwdxgk4z 162 4 MERS MERS NNP cord-328753-qwdxgk4z 162 5 - - HYPH cord-328753-qwdxgk4z 162 6 Coronaviruses Coronaviruses NNP cord-328753-qwdxgk4z 162 7 ( ( -LRB- cord-328753-qwdxgk4z 162 8 MERS MERS NNP cord-328753-qwdxgk4z 162 9 - - HYPH cord-328753-qwdxgk4z 162 10 CoV CoV NNP cord-328753-qwdxgk4z 162 11 ) ) -RRB- cord-328753-qwdxgk4z 162 12 [ [ -LRB- cord-328753-qwdxgk4z 162 13 87 87 CD cord-328753-qwdxgk4z 162 14 ] ] -RRB- cord-328753-qwdxgk4z 162 15 [ [ -LRB- cord-328753-qwdxgk4z 162 16 88 88 CD cord-328753-qwdxgk4z 162 17 ] ] -RRB- cord-328753-qwdxgk4z 162 18 [ [ -LRB- cord-328753-qwdxgk4z 162 19 89 89 CD cord-328753-qwdxgk4z 162 20 ] ] -RRB- cord-328753-qwdxgk4z 162 21 , , , cord-328753-qwdxgk4z 162 22 Crimean crimean JJ cord-328753-qwdxgk4z 162 23 Congo Congo NNP cord-328753-qwdxgk4z 162 24 hemorrhagic hemorrhagic JJ cord-328753-qwdxgk4z 162 25 fever fever NN cord-328753-qwdxgk4z 162 26 virus virus NN cord-328753-qwdxgk4z 162 27 ( ( -LRB- cord-328753-qwdxgk4z 162 28 CCHFV CCHFV NNP cord-328753-qwdxgk4z 162 29 ) ) -RRB- cord-328753-qwdxgk4z 162 30 [ [ -LRB- cord-328753-qwdxgk4z 162 31 90 90 CD cord-328753-qwdxgk4z 162 32 , , , cord-328753-qwdxgk4z 162 33 91 91 CD cord-328753-qwdxgk4z 162 34 ] ] -RRB- cord-328753-qwdxgk4z 162 35 , , , cord-328753-qwdxgk4z 162 36 Rift Rift NNP cord-328753-qwdxgk4z 162 37 Valley Valley NNP cord-328753-qwdxgk4z 162 38 fever fever NN cord-328753-qwdxgk4z 162 39 ( ( -LRB- cord-328753-qwdxgk4z 162 40 RFV RFV NNP cord-328753-qwdxgk4z 162 41 ) ) -RRB- cord-328753-qwdxgk4z 162 42 [ [ -LRB- cord-328753-qwdxgk4z 162 43 90 90 CD cord-328753-qwdxgk4z 162 44 ] ] -RRB- cord-328753-qwdxgk4z 162 45 , , , cord-328753-qwdxgk4z 162 46 Toxoplasma toxoplasma NN cord-328753-qwdxgk4z 162 47 gondii gondii NN cord-328753-qwdxgk4z 162 48 , , , cord-328753-qwdxgk4z 162 49 and and CC cord-328753-qwdxgk4z 162 50 Rickettsia Rickettsia NNP cord-328753-qwdxgk4z 162 51 sp sp NNP cord-328753-qwdxgk4z 162 52 . . . cord-328753-qwdxgk4z 163 1 [ [ -LRB- cord-328753-qwdxgk4z 163 2 92 92 CD cord-328753-qwdxgk4z 163 3 ] ] -RRB- cord-328753-qwdxgk4z 163 4 have have VBP cord-328753-qwdxgk4z 163 5 been be VBN cord-328753-qwdxgk4z 163 6 found find VBN cord-328753-qwdxgk4z 163 7 in in IN cord-328753-qwdxgk4z 163 8 the the DT cord-328753-qwdxgk4z 163 9 sera sera NNP cord-328753-qwdxgk4z 163 10 of of IN cord-328753-qwdxgk4z 163 11 infected infected JJ cord-328753-qwdxgk4z 163 12 camels camel NNS cord-328753-qwdxgk4z 163 13 , , , cord-328753-qwdxgk4z 163 14 whereas whereas IN cord-328753-qwdxgk4z 163 15 antibodies antibody NNS cord-328753-qwdxgk4z 163 16 against against IN cord-328753-qwdxgk4z 163 17 rabies rabies NN cord-328753-qwdxgk4z 163 18 virus virus NN cord-328753-qwdxgk4z 163 19 , , , cord-328753-qwdxgk4z 163 20 vesicular vesicular JJ cord-328753-qwdxgk4z 163 21 stomatitis stomatitis NN cord-328753-qwdxgk4z 163 22 virus virus NN cord-328753-qwdxgk4z 163 23 , , , cord-328753-qwdxgk4z 163 24 and and CC cord-328753-qwdxgk4z 163 25 FMD FMD NNP cord-328753-qwdxgk4z 163 26 virus virus NN cord-328753-qwdxgk4z 163 27 have have VBP cord-328753-qwdxgk4z 163 28 been be VBN cord-328753-qwdxgk4z 163 29 detected detect VBN cord-328753-qwdxgk4z 163 30 in in IN cord-328753-qwdxgk4z 163 31 llamas llama NNS cord-328753-qwdxgk4z 163 32 [ [ -LRB- cord-328753-qwdxgk4z 163 33 93 93 CD cord-328753-qwdxgk4z 163 34 ] ] -RRB- cord-328753-qwdxgk4z 163 35 and and CC cord-328753-qwdxgk4z 163 36 could could MD cord-328753-qwdxgk4z 163 37 lead lead VB cord-328753-qwdxgk4z 163 38 to to IN cord-328753-qwdxgk4z 163 39 the the DT cord-328753-qwdxgk4z 163 40 possible possible JJ cord-328753-qwdxgk4z 163 41 isolation isolation NN cord-328753-qwdxgk4z 163 42 of of IN cord-328753-qwdxgk4z 163 43 specific specific JJ cord-328753-qwdxgk4z 163 44 broadly broadly RB cord-328753-qwdxgk4z 163 45 neutralizing neutralize VBG cord-328753-qwdxgk4z 163 46 VHHs vhh NNS cord-328753-qwdxgk4z 163 47 . . . cord-328753-qwdxgk4z 164 1 Many many JJ cord-328753-qwdxgk4z 164 2 neutralizing neutralize VBG cord-328753-qwdxgk4z 164 3 VHHs vhh NNS cord-328753-qwdxgk4z 164 4 that that WDT cord-328753-qwdxgk4z 164 5 bind bind VBP cord-328753-qwdxgk4z 164 6 to to IN cord-328753-qwdxgk4z 164 7 different different JJ cord-328753-qwdxgk4z 164 8 sites site NNS cord-328753-qwdxgk4z 164 9 on on IN cord-328753-qwdxgk4z 164 10 the the DT cord-328753-qwdxgk4z 164 11 same same JJ cord-328753-qwdxgk4z 164 12 target target NN cord-328753-qwdxgk4z 164 13 , , , cord-328753-qwdxgk4z 164 14 including include VBG cord-328753-qwdxgk4z 164 15 hidden hidden JJ cord-328753-qwdxgk4z 164 16 antigenic antigenic JJ cord-328753-qwdxgk4z 164 17 sites site NNS cord-328753-qwdxgk4z 164 18 , , , cord-328753-qwdxgk4z 164 19 can can MD cord-328753-qwdxgk4z 164 20 be be VB cord-328753-qwdxgk4z 164 21 isolated isolate VBN cord-328753-qwdxgk4z 164 22 from from IN cord-328753-qwdxgk4z 164 23 immunized immunize VBN cord-328753-qwdxgk4z 164 24 or or CC cord-328753-qwdxgk4z 164 25 infected infected JJ cord-328753-qwdxgk4z 164 26 camelids camelid NNS cord-328753-qwdxgk4z 164 27 . . . cord-328753-qwdxgk4z 165 1 These these DT cord-328753-qwdxgk4z 165 2 VHHs vhh NNS cord-328753-qwdxgk4z 165 3 can can MD cord-328753-qwdxgk4z 165 4 be be VB cord-328753-qwdxgk4z 165 5 engineered engineer VBN cord-328753-qwdxgk4z 165 6 in in IN cord-328753-qwdxgk4z 165 7 various various JJ cord-328753-qwdxgk4z 165 8 ways way NNS cord-328753-qwdxgk4z 165 9 to to TO cord-328753-qwdxgk4z 165 10 improve improve VB cord-328753-qwdxgk4z 165 11 their -PRON- PRP$ cord-328753-qwdxgk4z 165 12 diagnostic diagnostic JJ cord-328753-qwdxgk4z 165 13 and/or and/or CC cord-328753-qwdxgk4z 165 14 therapeutic therapeutic JJ cord-328753-qwdxgk4z 165 15 properties property NNS cord-328753-qwdxgk4z 165 16 and and CC cord-328753-qwdxgk4z 165 17 efficacy efficacy NN cord-328753-qwdxgk4z 165 18 . . . cord-328753-qwdxgk4z 166 1 In in IN cord-328753-qwdxgk4z 166 2 addition addition NN cord-328753-qwdxgk4z 166 3 , , , cord-328753-qwdxgk4z 166 4 VHHs vhh NNS cord-328753-qwdxgk4z 166 5 readily readily RB cord-328753-qwdxgk4z 166 6 and and CC cord-328753-qwdxgk4z 166 7 rapidly rapidly RB cord-328753-qwdxgk4z 166 8 penetrate penetrate VBP cord-328753-qwdxgk4z 166 9 tissues tissue NNS cord-328753-qwdxgk4z 166 10 , , , cord-328753-qwdxgk4z 166 11 even even RB cord-328753-qwdxgk4z 166 12 the the DT cord-328753-qwdxgk4z 166 13 brain brain NN cord-328753-qwdxgk4z 166 14 , , , cord-328753-qwdxgk4z 166 15 and and CC cord-328753-qwdxgk4z 166 16 it -PRON- PRP cord-328753-qwdxgk4z 166 17 is be VBZ cord-328753-qwdxgk4z 166 18 likely likely JJ cord-328753-qwdxgk4z 166 19 that that IN cord-328753-qwdxgk4z 166 20 specific specific JJ cord-328753-qwdxgk4z 166 21 VHH vhh NN cord-328753-qwdxgk4z 166 22 - - HYPH cord-328753-qwdxgk4z 166 23 based base VBN cord-328753-qwdxgk4z 166 24 constructs construct NNS cord-328753-qwdxgk4z 166 25 will will MD cord-328753-qwdxgk4z 166 26 be be VB cord-328753-qwdxgk4z 166 27 developed develop VBN cord-328753-qwdxgk4z 166 28 that that WDT cord-328753-qwdxgk4z 166 29 can can MD cord-328753-qwdxgk4z 166 30 neutralize neutralize VB cord-328753-qwdxgk4z 166 31 agents agent NNS cord-328753-qwdxgk4z 166 32 involved involve VBN cord-328753-qwdxgk4z 166 33 in in IN cord-328753-qwdxgk4z 166 34 brain brain NN cord-328753-qwdxgk4z 166 35 infections infection NNS cord-328753-qwdxgk4z 166 36 , , , cord-328753-qwdxgk4z 166 37 such such JJ cord-328753-qwdxgk4z 166 38 as as IN cord-328753-qwdxgk4z 166 39 influenza influenza NN cord-328753-qwdxgk4z 166 40 [ [ -LRB- cord-328753-qwdxgk4z 166 41 68 68 CD cord-328753-qwdxgk4z 166 42 ] ] -RRB- cord-328753-qwdxgk4z 166 43 , , , cord-328753-qwdxgk4z 166 44 Zika Zika NNP cord-328753-qwdxgk4z 166 45 , , , cord-328753-qwdxgk4z 166 46 or or CC cord-328753-qwdxgk4z 166 47 rabies rabies NN cord-328753-qwdxgk4z 166 48 virus virus NN cord-328753-qwdxgk4z 166 49 . . . cord-328753-qwdxgk4z 167 1 Overall overall RB cord-328753-qwdxgk4z 167 2 , , , cord-328753-qwdxgk4z 167 3 VHHs vhh NNS cord-328753-qwdxgk4z 167 4 or or CC cord-328753-qwdxgk4z 167 5 VHH vhh NN cord-328753-qwdxgk4z 167 6 - - HYPH cord-328753-qwdxgk4z 167 7 based base VBN cord-328753-qwdxgk4z 167 8 molecules molecule NNS cord-328753-qwdxgk4z 167 9 are be VBP cord-328753-qwdxgk4z 167 10 potentially potentially RB cord-328753-qwdxgk4z 167 11 valuable valuable JJ cord-328753-qwdxgk4z 167 12 diagnostic diagnostic JJ cord-328753-qwdxgk4z 167 13 and and CC cord-328753-qwdxgk4z 167 14 therapeutic therapeutic JJ cord-328753-qwdxgk4z 167 15 reagents reagent NNS cord-328753-qwdxgk4z 167 16 to to TO cord-328753-qwdxgk4z 167 17 treat treat VB cord-328753-qwdxgk4z 167 18 ZDs ZDs NNP cord-328753-qwdxgk4z 167 19 . . . cord-328753-qwdxgk4z 168 1 Expression expression NN cord-328753-qwdxgk4z 168 2 of of IN cord-328753-qwdxgk4z 168 3 anti anti JJ cord-328753-qwdxgk4z 168 4 human human JJ cord-328753-qwdxgk4z 168 5 IL-4 IL-4 NNP cord-328753-qwdxgk4z 168 6 and and CC cord-328753-qwdxgk4z 168 7 IL-6 IL-6 NNP cord-328753-qwdxgk4z 168 8 scFvs scFvs NNP cord-328753-qwdxgk4z 168 9 in in IN cord-328753-qwdxgk4z 168 10 transgenic transgenic JJ cord-328753-qwdxgk4z 168 11 tobacco tobacco NN cord-328753-qwdxgk4z 168 12 plants plant NNS cord-328753-qwdxgk4z 168 13 Antibody Antibody NNP cord-328753-qwdxgk4z 168 14 repertoire repertoire NN cord-328753-qwdxgk4z 168 15 development development NN cord-328753-qwdxgk4z 168 16 in in IN cord-328753-qwdxgk4z 168 17 cartilaginous cartilaginous JJ cord-328753-qwdxgk4z 168 18 fish fish NN cord-328753-qwdxgk4z 168 19 Medicine medicine NN cord-328753-qwdxgk4z 168 20 and and CC cord-328753-qwdxgk4z 168 21 Surgery Surgery NNP cord-328753-qwdxgk4z 168 22 of of IN cord-328753-qwdxgk4z 168 23 South south JJ cord-328753-qwdxgk4z 168 24 American American NNP cord-328753-qwdxgk4z 168 25 Camelids Camelids NNP cord-328753-qwdxgk4z 168 26 Dromedary Dromedary NNP cord-328753-qwdxgk4z 168 27 IgG igg NN cord-328753-qwdxgk4z 168 28 : : : cord-328753-qwdxgk4z 168 29 purification purification NN cord-328753-qwdxgk4z 168 30 , , , cord-328753-qwdxgk4z 168 31 characterization characterization NN cord-328753-qwdxgk4z 168 32 and and CC cord-328753-qwdxgk4z 168 33 quantitation quantitation NN cord-328753-qwdxgk4z 168 34 in in IN cord-328753-qwdxgk4z 168 35 sera sera NNP cord-328753-qwdxgk4z 168 36 of of IN cord-328753-qwdxgk4z 168 37 dams dam NNS cord-328753-qwdxgk4z 168 38 and and CC cord-328753-qwdxgk4z 168 39 new new JJ cord-328753-qwdxgk4z 168 40 - - HYPH cord-328753-qwdxgk4z 168 41 borns born NNS cord-328753-qwdxgk4z 169 1 The the DT cord-328753-qwdxgk4z 169 2 isolation isolation NN cord-328753-qwdxgk4z 169 3 and and CC cord-328753-qwdxgk4z 169 4 characterization characterization NN cord-328753-qwdxgk4z 169 5 of of IN cord-328753-qwdxgk4z 169 6 camel camel NN cord-328753-qwdxgk4z 169 7 ( ( -LRB- cord-328753-qwdxgk4z 169 8 Camelus Camelus NNP cord-328753-qwdxgk4z 169 9 dromedarius dromedarius NN cord-328753-qwdxgk4z 169 10 ) ) -RRB- cord-328753-qwdxgk4z 169 11 immunoglobulin immunoglobulin NN cord-328753-qwdxgk4z 169 12 classes class NNS cord-328753-qwdxgk4z 169 13 and and CC cord-328753-qwdxgk4z 169 14 subclasses subclass NNS cord-328753-qwdxgk4z 169 15 Naturally naturally RB cord-328753-qwdxgk4z 169 16 occurring occur VBG cord-328753-qwdxgk4z 169 17 antibodies antibody NNS cord-328753-qwdxgk4z 169 18 devoid devoid JJ cord-328753-qwdxgk4z 169 19 of of IN cord-328753-qwdxgk4z 169 20 light light JJ cord-328753-qwdxgk4z 169 21 chains chain NNS cord-328753-qwdxgk4z 169 22 Selection selection NN cord-328753-qwdxgk4z 169 23 and and CC cord-328753-qwdxgk4z 169 24 identification identification NN cord-328753-qwdxgk4z 169 25 of of IN cord-328753-qwdxgk4z 169 26 single single JJ cord-328753-qwdxgk4z 169 27 domain domain NN cord-328753-qwdxgk4z 169 28 antibody antibody NN cord-328753-qwdxgk4z 169 29 fragments fragment NNS cord-328753-qwdxgk4z 169 30 from from IN cord-328753-qwdxgk4z 169 31 camel camel NN cord-328753-qwdxgk4z 169 32 heavy heavy JJ cord-328753-qwdxgk4z 169 33 - - HYPH cord-328753-qwdxgk4z 169 34 chain chain NN cord-328753-qwdxgk4z 169 35 antibodies antibody NNS cord-328753-qwdxgk4z 169 36 Nanobodies Nanobodies NNP cord-328753-qwdxgk4z 169 37 : : : cord-328753-qwdxgk4z 169 38 natural natural JJ cord-328753-qwdxgk4z 169 39 single single JJ cord-328753-qwdxgk4z 169 40 - - HYPH cord-328753-qwdxgk4z 169 41 domain domain NN cord-328753-qwdxgk4z 169 42 antibodies antibody NNS cord-328753-qwdxgk4z 169 43 Functional functional JJ cord-328753-qwdxgk4z 169 44 heavy heavy JJ cord-328753-qwdxgk4z 169 45 - - HYPH cord-328753-qwdxgk4z 169 46 chain chain NN cord-328753-qwdxgk4z 169 47 antibodies antibody NNS cord-328753-qwdxgk4z 169 48 in in IN cord-328753-qwdxgk4z 169 49 Camelidae Camelidae NNP cord-328753-qwdxgk4z 169 50 Selection Selection NNP cord-328753-qwdxgk4z 169 51 of of IN cord-328753-qwdxgk4z 169 52 similar similar JJ cord-328753-qwdxgk4z 169 53 single single JJ cord-328753-qwdxgk4z 169 54 domain domain NN cord-328753-qwdxgk4z 169 55 antibodies antibody NNS cord-328753-qwdxgk4z 169 56 from from IN cord-328753-qwdxgk4z 169 57 two two CD cord-328753-qwdxgk4z 169 58 immune immune JJ cord-328753-qwdxgk4z 169 59 VHH vhh NN cord-328753-qwdxgk4z 169 60 libraries library NNS cord-328753-qwdxgk4z 169 61 obtained obtain VBN cord-328753-qwdxgk4z 169 62 from from IN cord-328753-qwdxgk4z 169 63 two two CD cord-328753-qwdxgk4z 169 64 alpacas alpaca NNS cord-328753-qwdxgk4z 169 65 by by IN cord-328753-qwdxgk4z 169 66 using use VBG cord-328753-qwdxgk4z 169 67 different different JJ cord-328753-qwdxgk4z 169 68 selection selection NN cord-328753-qwdxgk4z 169 69 methods method NNS cord-328753-qwdxgk4z 170 1 Single single JJ cord-328753-qwdxgk4z 170 2 domain domain NN cord-328753-qwdxgk4z 170 3 antibodies antibody NNS cord-328753-qwdxgk4z 170 4 : : : cord-328753-qwdxgk4z 170 5 promising promise VBG cord-328753-qwdxgk4z 170 6 experimental experimental JJ cord-328753-qwdxgk4z 170 7 and and CC cord-328753-qwdxgk4z 170 8 therapeutic therapeutic JJ cord-328753-qwdxgk4z 170 9 tools tool NNS cord-328753-qwdxgk4z 170 10 in in IN cord-328753-qwdxgk4z 170 11 infection infection NN cord-328753-qwdxgk4z 170 12 and and CC cord-328753-qwdxgk4z 170 13 immunity immunity NN cord-328753-qwdxgk4z 170 14 Single single JJ cord-328753-qwdxgk4z 170 15 domain domain NN cord-328753-qwdxgk4z 170 16 camel camel NN cord-328753-qwdxgk4z 170 17 antibodies antibody NNS cord-328753-qwdxgk4z 170 18 : : : cord-328753-qwdxgk4z 170 19 current current JJ cord-328753-qwdxgk4z 170 20 status status NN cord-328753-qwdxgk4z 170 21 Efficient efficient JJ cord-328753-qwdxgk4z 170 22 tumor tumor NN cord-328753-qwdxgk4z 170 23 targeting target VBG cord-328753-qwdxgk4z 170 24 by by IN cord-328753-qwdxgk4z 170 25 singledomain singledomain NNP cord-328753-qwdxgk4z 170 26 antibody antibody NN cord-328753-qwdxgk4z 170 27 fragments fragment NNS cord-328753-qwdxgk4z 170 28 of of IN cord-328753-qwdxgk4z 170 29 camels camel NNS cord-328753-qwdxgk4z 170 30 novel novel VBP cord-328753-qwdxgk4z 170 31 promiscuous promiscuous JJ cord-328753-qwdxgk4z 170 32 class class NN cord-328753-qwdxgk4z 170 33 of of IN cord-328753-qwdxgk4z 170 34 camelid camelid NN cord-328753-qwdxgk4z 170 35 single single JJ cord-328753-qwdxgk4z 170 36 - - HYPH cord-328753-qwdxgk4z 170 37 domain domain NN cord-328753-qwdxgk4z 170 38 antibody antibody NN cord-328753-qwdxgk4z 170 39 contributes contribute VBZ cord-328753-qwdxgk4z 170 40 to to IN cord-328753-qwdxgk4z 170 41 the the DT cord-328753-qwdxgk4z 170 42 antigen antigen NN cord-328753-qwdxgk4z 170 43 - - HYPH cord-328753-qwdxgk4z 170 44 binding bind VBG cord-328753-qwdxgk4z 170 45 repertoire repertoire NN cord-328753-qwdxgk4z 170 46 Properties property NNS cord-328753-qwdxgk4z 170 47 , , , cord-328753-qwdxgk4z 170 48 production production NN cord-328753-qwdxgk4z 170 49 , , , cord-328753-qwdxgk4z 170 50 and and CC cord-328753-qwdxgk4z 170 51 applications application NNS cord-328753-qwdxgk4z 170 52 of of IN cord-328753-qwdxgk4z 170 53 camelid camelid NNP cord-328753-qwdxgk4z 170 54 single single JJ cord-328753-qwdxgk4z 170 55 - - HYPH cord-328753-qwdxgk4z 170 56 domain domain NN cord-328753-qwdxgk4z 170 57 antibody antibody NN cord-328753-qwdxgk4z 170 58 fragments fragment VBZ cord-328753-qwdxgk4z 170 59 Isolation isolation NN cord-328753-qwdxgk4z 170 60 and and CC cord-328753-qwdxgk4z 170 61 characterization characterization NN cord-328753-qwdxgk4z 170 62 of of IN cord-328753-qwdxgk4z 170 63 a a DT cord-328753-qwdxgk4z 170 64 thermally thermally RB cord-328753-qwdxgk4z 170 65 stable stable JJ cord-328753-qwdxgk4z 170 66 recombinant recombinant JJ cord-328753-qwdxgk4z 170 67 anti anti JJ cord-328753-qwdxgk4z 170 68 - - JJ cord-328753-qwdxgk4z 170 69 caffeine caffeine JJ cord-328753-qwdxgk4z 170 70 heavy heavy JJ cord-328753-qwdxgk4z 170 71 - - HYPH cord-328753-qwdxgk4z 170 72 chain chain NN cord-328753-qwdxgk4z 170 73 antibody antibody NN cord-328753-qwdxgk4z 170 74 fragment fragment NN cord-328753-qwdxgk4z 170 75 Antigen Antigen NNP cord-328753-qwdxgk4z 170 76 specificity specificity NN cord-328753-qwdxgk4z 170 77 and and CC cord-328753-qwdxgk4z 170 78 high high JJ cord-328753-qwdxgk4z 170 79 affinity affinity NN cord-328753-qwdxgk4z 170 80 binding binding NN cord-328753-qwdxgk4z 170 81 provided provide VBN cord-328753-qwdxgk4z 170 82 by by IN cord-328753-qwdxgk4z 170 83 one one CD cord-328753-qwdxgk4z 170 84 single single JJ cord-328753-qwdxgk4z 170 85 loop loop NN cord-328753-qwdxgk4z 170 86 of of IN cord-328753-qwdxgk4z 170 87 a a DT cord-328753-qwdxgk4z 170 88 camel camel NN cord-328753-qwdxgk4z 170 89 single single JJ cord-328753-qwdxgk4z 170 90 - - HYPH cord-328753-qwdxgk4z 170 91 domain domain NN cord-328753-qwdxgk4z 170 92 antibody antibody NN cord-328753-qwdxgk4z 170 93 Experimental experimental JJ cord-328753-qwdxgk4z 170 94 therapy therapy NN cord-328753-qwdxgk4z 170 95 of of IN cord-328753-qwdxgk4z 170 96 African african JJ cord-328753-qwdxgk4z 170 97 trypanosomiasis trypanosomiasis NN cord-328753-qwdxgk4z 170 98 with with IN cord-328753-qwdxgk4z 170 99 a a DT cord-328753-qwdxgk4z 170 100 nanobody nanobody NN cord-328753-qwdxgk4z 170 101 - - HYPH cord-328753-qwdxgk4z 170 102 conjugated conjugate VBN cord-328753-qwdxgk4z 170 103 human human JJ cord-328753-qwdxgk4z 170 104 trypanolytic trypanolytic JJ cord-328753-qwdxgk4z 170 105 factor factor NN cord-328753-qwdxgk4z 170 106 Camelid Camelid NNP cord-328753-qwdxgk4z 171 1 heavy heavy JJ cord-328753-qwdxgk4z 171 2 - - HYPH cord-328753-qwdxgk4z 171 3 chain chain NN cord-328753-qwdxgk4z 171 4 variable variable NN cord-328753-qwdxgk4z 171 5 domains domain NNS cord-328753-qwdxgk4z 171 6 provide provide VBP cord-328753-qwdxgk4z 171 7 efficient efficient JJ cord-328753-qwdxgk4z 171 8 combining combine VBG cord-328753-qwdxgk4z 171 9 sites site NNS cord-328753-qwdxgk4z 171 10 to to IN cord-328753-qwdxgk4z 171 11 haptens hapten NNS cord-328753-qwdxgk4z 171 12 Crystal Crystal NNP cord-328753-qwdxgk4z 171 13 structure structure NN cord-328753-qwdxgk4z 171 14 of of IN cord-328753-qwdxgk4z 171 15 a a DT cord-328753-qwdxgk4z 171 16 camel camel NN cord-328753-qwdxgk4z 171 17 single single JJ cord-328753-qwdxgk4z 171 18 - - HYPH cord-328753-qwdxgk4z 171 19 domain domain NN cord-328753-qwdxgk4z 171 20 VH VH NNP cord-328753-qwdxgk4z 171 21 antibody antibody NN cord-328753-qwdxgk4z 171 22 fragment fragment NN cord-328753-qwdxgk4z 171 23 in in IN cord-328753-qwdxgk4z 171 24 complex complex NN cord-328753-qwdxgk4z 171 25 with with IN cord-328753-qwdxgk4z 172 1 lysozyme lysozyme NNP cord-328753-qwdxgk4z 172 2 Single Single NNP cord-328753-qwdxgk4z 172 3 - - HYPH cord-328753-qwdxgk4z 172 4 domain domain NN cord-328753-qwdxgk4z 172 5 antibodies antibody NNS cord-328753-qwdxgk4z 172 6 recognize recognize VBP cord-328753-qwdxgk4z 172 7 selectively selectively RB cord-328753-qwdxgk4z 172 8 small small JJ cord-328753-qwdxgk4z 172 9 oligomeric oligomeric JJ cord-328753-qwdxgk4z 172 10 forms form NNS cord-328753-qwdxgk4z 172 11 of of IN cord-328753-qwdxgk4z 172 12 amyloid amyloid NN cord-328753-qwdxgk4z 172 13 β β NN cord-328753-qwdxgk4z 172 14 , , , cord-328753-qwdxgk4z 172 15 prevent prevent VB cord-328753-qwdxgk4z 172 16 Aβ aβ NN cord-328753-qwdxgk4z 172 17 - - HYPH cord-328753-qwdxgk4z 172 18 induced induce VBN cord-328753-qwdxgk4z 172 19 neurotoxicity neurotoxicity NN cord-328753-qwdxgk4z 172 20 and and CC cord-328753-qwdxgk4z 172 21 inhibit inhibit NN cord-328753-qwdxgk4z 172 22 fibril fibril NN cord-328753-qwdxgk4z 172 23 formation formation NN cord-328753-qwdxgk4z 173 1 Single single JJ cord-328753-qwdxgk4z 173 2 domain domain NN cord-328753-qwdxgk4z 173 3 antibodies antibody NNS cord-328753-qwdxgk4z 173 4 as as IN cord-328753-qwdxgk4z 173 5 blood blood NN cord-328753-qwdxgk4z 173 6 - - HYPH cord-328753-qwdxgk4z 173 7 brain brain NN cord-328753-qwdxgk4z 173 8 barrier barrier NN cord-328753-qwdxgk4z 173 9 delivery delivery NN cord-328753-qwdxgk4z 173 10 vectors vector NNS cord-328753-qwdxgk4z 173 11 Llama Llama NNP cord-328753-qwdxgk4z 173 12 VHH VHH NNP cord-328753-qwdxgk4z 173 13 antibody antibody NN cord-328753-qwdxgk4z 173 14 fragments fragment NNS cord-328753-qwdxgk4z 173 15 against against IN cord-328753-qwdxgk4z 173 16 GFAP GFAP NNP cord-328753-qwdxgk4z 173 17 : : : cord-328753-qwdxgk4z 173 18 better well JJR cord-328753-qwdxgk4z 173 19 diffusion diffusion NN cord-328753-qwdxgk4z 173 20 in in IN cord-328753-qwdxgk4z 173 21 fixed fix VBN cord-328753-qwdxgk4z 173 22 tissues tissue NNS cord-328753-qwdxgk4z 173 23 than than IN cord-328753-qwdxgk4z 173 24 classical classical JJ cord-328753-qwdxgk4z 173 25 monoclonal monoclonal JJ cord-328753-qwdxgk4z 173 26 antibodies antibody NNS cord-328753-qwdxgk4z 173 27 Cell cell NN cord-328753-qwdxgk4z 173 28 - - HYPH cord-328753-qwdxgk4z 173 29 penetrating penetrate VBG cord-328753-qwdxgk4z 173 30 anti anti JJ cord-328753-qwdxgk4z 173 31 - - JJ cord-328753-qwdxgk4z 173 32 GFAP gfap JJ cord-328753-qwdxgk4z 173 33 VHH vhh NN cord-328753-qwdxgk4z 173 34 and and CC cord-328753-qwdxgk4z 174 1 corresponding correspond VBG cord-328753-qwdxgk4z 174 2 fluorescent fluorescent JJ cord-328753-qwdxgk4z 174 3 fusion fusion NN cord-328753-qwdxgk4z 174 4 protein protein NN cord-328753-qwdxgk4z 174 5 VHH VHH NNP cord-328753-qwdxgk4z 174 6 - - HYPH cord-328753-qwdxgk4z 174 7 GFP GFP NNP cord-328753-qwdxgk4z 174 8 spontaneously spontaneously RB cord-328753-qwdxgk4z 174 9 cross cross VBP cord-328753-qwdxgk4z 174 10 the the DT cord-328753-qwdxgk4z 174 11 blood blood NN cord-328753-qwdxgk4z 174 12 - - HYPH cord-328753-qwdxgk4z 174 13 brain brain NN cord-328753-qwdxgk4z 174 14 barrier barrier NN cord-328753-qwdxgk4z 174 15 and and CC cord-328753-qwdxgk4z 174 16 specifically specifically RB cord-328753-qwdxgk4z 174 17 recognize recognize VB cord-328753-qwdxgk4z 174 18 astrocytes astrocyte NNS cord-328753-qwdxgk4z 174 19 : : : cord-328753-qwdxgk4z 174 20 application application NN cord-328753-qwdxgk4z 174 21 to to IN cord-328753-qwdxgk4z 174 22 brain brain NN cord-328753-qwdxgk4z 174 23 imaging image VBG cord-328753-qwdxgk4z 174 24 Camelid Camelid NNP cord-328753-qwdxgk4z 174 25 single single JJ cord-328753-qwdxgk4z 174 26 - - HYPH cord-328753-qwdxgk4z 174 27 domain domain NN cord-328753-qwdxgk4z 174 28 antibodies antibody NNS cord-328753-qwdxgk4z 174 29 : : : cord-328753-qwdxgk4z 174 30 a a DT cord-328753-qwdxgk4z 174 31 versatile versatile JJ cord-328753-qwdxgk4z 174 32 tool tool NN cord-328753-qwdxgk4z 174 33 for for IN cord-328753-qwdxgk4z 174 34 in in IN cord-328753-qwdxgk4z 174 35 vivo vivo NN cord-328753-qwdxgk4z 174 36 imaging imaging NN cord-328753-qwdxgk4z 174 37 of of IN cord-328753-qwdxgk4z 174 38 extracellular extracellular JJ cord-328753-qwdxgk4z 174 39 and and CC cord-328753-qwdxgk4z 174 40 intracellular intracellular JJ cord-328753-qwdxgk4z 174 41 brain brain NN cord-328753-qwdxgk4z 174 42 targets target NNS cord-328753-qwdxgk4z 174 43 Chemically chemically RB cord-328753-qwdxgk4z 174 44 - - HYPH cord-328753-qwdxgk4z 174 45 defined define VBN cord-328753-qwdxgk4z 174 46 camelid camelid NN cord-328753-qwdxgk4z 174 47 antibody antibody NN cord-328753-qwdxgk4z 174 48 bioconjugate bioconjugate NNP cord-328753-qwdxgk4z 174 49 for for IN cord-328753-qwdxgk4z 174 50 the the DT cord-328753-qwdxgk4z 174 51 magnetic magnetic JJ cord-328753-qwdxgk4z 174 52 resonance resonance NN cord-328753-qwdxgk4z 174 53 imaging imaging NN cord-328753-qwdxgk4z 174 54 of of IN cord-328753-qwdxgk4z 174 55 Alzheimer Alzheimer NNP cord-328753-qwdxgk4z 174 56 's 's POS cord-328753-qwdxgk4z 174 57 disease disease NN cord-328753-qwdxgk4z 174 58 Sortagging Sortagging NNP cord-328753-qwdxgk4z 174 59 : : : cord-328753-qwdxgk4z 174 60 a a DT cord-328753-qwdxgk4z 174 61 versatile versatile JJ cord-328753-qwdxgk4z 174 62 method method NN cord-328753-qwdxgk4z 174 63 for for IN cord-328753-qwdxgk4z 174 64 protein protein NN cord-328753-qwdxgk4z 174 65 labeling labeling NN cord-328753-qwdxgk4z 174 66 Sortase Sortase NNP cord-328753-qwdxgk4z 174 67 A A NNP cord-328753-qwdxgk4z 174 68 - - HYPH cord-328753-qwdxgk4z 174 69 mediated mediate VBN cord-328753-qwdxgk4z 174 70 sitespecific sitespecific NN cord-328753-qwdxgk4z 174 71 labeling labeling NN cord-328753-qwdxgk4z 174 72 of of IN cord-328753-qwdxgk4z 174 73 camelid camelid NNP cord-328753-qwdxgk4z 174 74 single single JJ cord-328753-qwdxgk4z 174 75 - - HYPH cord-328753-qwdxgk4z 174 76 domain domain NN cord-328753-qwdxgk4z 174 77 antibody antibody NN cord-328753-qwdxgk4z 174 78 - - HYPH cord-328753-qwdxgk4z 174 79 fragments fragment NNS cord-328753-qwdxgk4z 174 80 : : : cord-328753-qwdxgk4z 174 81 a a DT cord-328753-qwdxgk4z 174 82 versatile versatile JJ cord-328753-qwdxgk4z 174 83 strategy strategy NN cord-328753-qwdxgk4z 174 84 for for IN cord-328753-qwdxgk4z 174 85 multiple multiple JJ cord-328753-qwdxgk4z 174 86 molecular molecular JJ cord-328753-qwdxgk4z 174 87 imaging imaging NN cord-328753-qwdxgk4z 174 88 modalities modality NNS cord-328753-qwdxgk4z 174 89 Site site NN cord-328753-qwdxgk4z 174 90 - - HYPH cord-328753-qwdxgk4z 174 91 specific specific JJ cord-328753-qwdxgk4z 174 92 labeling labeling NN cord-328753-qwdxgk4z 174 93 of of IN cord-328753-qwdxgk4z 174 94 cysteine cysteine NN cord-328753-qwdxgk4z 174 95 - - HYPH cord-328753-qwdxgk4z 174 96 tagged tag VBN cord-328753-qwdxgk4z 174 97 camelid camelid NNP cord-328753-qwdxgk4z 174 98 single single JJ cord-328753-qwdxgk4z 174 99 - - HYPH cord-328753-qwdxgk4z 174 100 domain domain NN cord-328753-qwdxgk4z 174 101 antibody antibody NN cord-328753-qwdxgk4z 174 102 - - HYPH cord-328753-qwdxgk4z 174 103 fragments fragment NNS cord-328753-qwdxgk4z 174 104 for for IN cord-328753-qwdxgk4z 174 105 use use NN cord-328753-qwdxgk4z 174 106 in in IN cord-328753-qwdxgk4z 174 107 molecular molecular JJ cord-328753-qwdxgk4z 174 108 imaging imaging NN cord-328753-qwdxgk4z 174 109 Under under IN cord-328753-qwdxgk4z 174 110 the the DT cord-328753-qwdxgk4z 174 111 Microscope microscope NN cord-328753-qwdxgk4z 174 112 : : : cord-328753-qwdxgk4z 174 113 Single single JJ cord-328753-qwdxgk4z 174 114 - - HYPH cord-328753-qwdxgk4z 174 115 Domain domain NN cord-328753-qwdxgk4z 174 116 Antibodies Antibodies NNPS cord-328753-qwdxgk4z 174 117 for for IN cord-328753-qwdxgk4z 174 118 Live live JJ cord-328753-qwdxgk4z 174 119 - - HYPH cord-328753-qwdxgk4z 174 120 Cell Cell NNP cord-328753-qwdxgk4z 174 121 Imaging Imaging NNP cord-328753-qwdxgk4z 174 122 and and CC cord-328753-qwdxgk4z 174 123 Super Super NNP cord-328753-qwdxgk4z 174 124 - - NNP cord-328753-qwdxgk4z 174 125 Resolution Resolution NNP cord-328753-qwdxgk4z 174 126 Microscopy Microscopy NNP cord-328753-qwdxgk4z 174 127 VHH vhh NN cord-328753-qwdxgk4z 174 128 - - HYPH cord-328753-qwdxgk4z 174 129 based base VBN cord-328753-qwdxgk4z 174 130 bispecific bispecific NN cord-328753-qwdxgk4z 174 131 antibodies antibody NNS cord-328753-qwdxgk4z 174 132 targeting target VBG cord-328753-qwdxgk4z 174 133 cytokine cytokine NN cord-328753-qwdxgk4z 174 134 production production NN cord-328753-qwdxgk4z 174 135 Selection selection NN cord-328753-qwdxgk4z 174 136 of of IN cord-328753-qwdxgk4z 174 137 nanobodies nanobodie NNS cord-328753-qwdxgk4z 174 138 with with IN cord-328753-qwdxgk4z 174 139 broad broad JJ cord-328753-qwdxgk4z 174 140 neutralizing neutralize VBG cord-328753-qwdxgk4z 174 141 potential potential NN cord-328753-qwdxgk4z 174 142 against against IN cord-328753-qwdxgk4z 174 143 primary primary JJ cord-328753-qwdxgk4z 174 144 HIV-1 HIV-1 NNP cord-328753-qwdxgk4z 174 145 strains strain NNS cord-328753-qwdxgk4z 174 146 using use VBG cord-328753-qwdxgk4z 174 147 soluble soluble JJ cord-328753-qwdxgk4z 174 148 subtype subtype NN cord-328753-qwdxgk4z 174 149 C c NN cord-328753-qwdxgk4z 174 150 gp140 gp140 CD cord-328753-qwdxgk4z 174 151 envelope envelope NN cord-328753-qwdxgk4z 174 152 trimers trimer VBZ cord-328753-qwdxgk4z 174 153 Single single JJ cord-328753-qwdxgk4z 174 154 - - HYPH cord-328753-qwdxgk4z 174 155 domain domain NN cord-328753-qwdxgk4z 174 156 antibodies antibody NNS cord-328753-qwdxgk4z 174 157 as as IN cord-328753-qwdxgk4z 174 158 versatile versatile JJ cord-328753-qwdxgk4z 174 159 affinity affinity NN cord-328753-qwdxgk4z 174 160 reagents reagent NNS cord-328753-qwdxgk4z 174 161 for for IN cord-328753-qwdxgk4z 174 162 analytical analytical JJ cord-328753-qwdxgk4z 174 163 and and CC cord-328753-qwdxgk4z 174 164 diagnostic diagnostic JJ cord-328753-qwdxgk4z 174 165 applications application NNS cord-328753-qwdxgk4z 174 166 Nanobodies Nanobodies NNPS cord-328753-qwdxgk4z 174 167 and and CC cord-328753-qwdxgk4z 174 168 their -PRON- PRP$ cord-328753-qwdxgk4z 174 169 potential potential JJ cord-328753-qwdxgk4z 174 170 applications application NNS cord-328753-qwdxgk4z 175 1 An an DT cord-328753-qwdxgk4z 175 2 alpaca alpaca NN cord-328753-qwdxgk4z 175 3 nanobody nanobody NN cord-328753-qwdxgk4z 175 4 inhibits inhibit VBZ cord-328753-qwdxgk4z 175 5 hepatitis hepatitis NNP cord-328753-qwdxgk4z 175 6 C C NNP cord-328753-qwdxgk4z 175 7 virus virus NN cord-328753-qwdxgk4z 175 8 entry entry NN cord-328753-qwdxgk4z 175 9 and and CC cord-328753-qwdxgk4z 175 10 cell cell NN cord-328753-qwdxgk4z 175 11 - - HYPH cord-328753-qwdxgk4z 175 12 to to IN cord-328753-qwdxgk4z 175 13 - - HYPH cord-328753-qwdxgk4z 175 14 cell cell NN cord-328753-qwdxgk4z 175 15 transmission transmission NN cord-328753-qwdxgk4z 175 16 Ebola Ebola NNP cord-328753-qwdxgk4z 175 17 : : : cord-328753-qwdxgk4z 176 1 Lessons lesson NNS cord-328753-qwdxgk4z 176 2 learned learn VBD cord-328753-qwdxgk4z 176 3 and and CC cord-328753-qwdxgk4z 176 4 future future JJ cord-328753-qwdxgk4z 176 5 challenges challenge NNS cord-328753-qwdxgk4z 176 6 for for IN cord-328753-qwdxgk4z 176 7 Europe Europe NNP cord-328753-qwdxgk4z 176 8 A A NNP cord-328753-qwdxgk4z 176 9 Comprehensive Comprehensive NNP cord-328753-qwdxgk4z 176 10 Review Review NNP cord-328753-qwdxgk4z 176 11 of of IN cord-328753-qwdxgk4z 176 12 Common Common NNP cord-328753-qwdxgk4z 176 13 Bacterial Bacterial NNP cord-328753-qwdxgk4z 176 14 , , , cord-328753-qwdxgk4z 176 15 Parasitic parasitic JJ cord-328753-qwdxgk4z 176 16 and and CC cord-328753-qwdxgk4z 176 17 Viral Viral NNP cord-328753-qwdxgk4z 176 18 Zoonoses Zoonoses NNP cord-328753-qwdxgk4z 176 19 at at IN cord-328753-qwdxgk4z 176 20 the the DT cord-328753-qwdxgk4z 176 21 Human Human NNP cord-328753-qwdxgk4z 176 22 - - HYPH cord-328753-qwdxgk4z 176 23 Animal Animal NNP cord-328753-qwdxgk4z 176 24 Interface Interface NNP cord-328753-qwdxgk4z 176 25 in in IN cord-328753-qwdxgk4z 176 26 Egypt Egypt NNP cord-328753-qwdxgk4z 176 27 , , , cord-328753-qwdxgk4z 176 28 Pathog Pathog NNP cord-328753-qwdxgk4z 176 29 Pentavalent Pentavalent NNP cord-328753-qwdxgk4z 176 30 singledomain singledomain NN cord-328753-qwdxgk4z 176 31 antibodies antibody NNS cord-328753-qwdxgk4z 176 32 reduce reduce VBP cord-328753-qwdxgk4z 176 33 Campylobacter Campylobacter NNP cord-328753-qwdxgk4z 176 34 jejuni jejuni JJ cord-328753-qwdxgk4z 176 35 motility motility NN cord-328753-qwdxgk4z 176 36 and and CC cord-328753-qwdxgk4z 176 37 colonization colonization NN cord-328753-qwdxgk4z 176 38 in in IN cord-328753-qwdxgk4z 176 39 chickens chicken NNS cord-328753-qwdxgk4z 176 40 Protease Protease NNP cord-328753-qwdxgk4z 176 41 - - HYPH cord-328753-qwdxgk4z 176 42 resistant resistant JJ cord-328753-qwdxgk4z 176 43 single single JJ cord-328753-qwdxgk4z 176 44 - - HYPH cord-328753-qwdxgk4z 176 45 domain domain NN cord-328753-qwdxgk4z 176 46 antibodies antibody NNS cord-328753-qwdxgk4z 177 1 inhibit inhibit VB cord-328753-qwdxgk4z 177 2 Campylobacter Campylobacter NNP cord-328753-qwdxgk4z 177 3 jejuni jejuni JJ cord-328753-qwdxgk4z 177 4 motility motility NN cord-328753-qwdxgk4z 177 5 Nanobodies Nanobodies NNPS cord-328753-qwdxgk4z 177 6 targeting target VBG cord-328753-qwdxgk4z 177 7 conserved conserve VBN cord-328753-qwdxgk4z 177 8 epitopes epitope NNS cord-328753-qwdxgk4z 177 9 on on IN cord-328753-qwdxgk4z 177 10 the the DT cord-328753-qwdxgk4z 177 11 major major JJ cord-328753-qwdxgk4z 177 12 outer outer JJ cord-328753-qwdxgk4z 177 13 membrane membrane NN cord-328753-qwdxgk4z 177 14 protein protein NN cord-328753-qwdxgk4z 177 15 of of IN cord-328753-qwdxgk4z 177 16 Campylobacter Campylobacter NNP cord-328753-qwdxgk4z 177 17 as as IN cord-328753-qwdxgk4z 177 18 potential potential JJ cord-328753-qwdxgk4z 177 19 tools tool NNS cord-328753-qwdxgk4z 177 20 for for IN cord-328753-qwdxgk4z 177 21 control control NN cord-328753-qwdxgk4z 177 22 of of IN cord-328753-qwdxgk4z 177 23 Campylobacter Campylobacter NNP cord-328753-qwdxgk4z 177 24 colonization colonization NN cord-328753-qwdxgk4z 177 25 Zoonotic Zoonotic NNP cord-328753-qwdxgk4z 177 26 enterohemorrhagic enterohemorrhagic NN cord-328753-qwdxgk4z 177 27 Escherichia Escherichia NNP cord-328753-qwdxgk4z 177 28 coli coli NNS cord-328753-qwdxgk4z 177 29 : : : cord-328753-qwdxgk4z 178 1 A a DT cord-328753-qwdxgk4z 178 2 One One NNP cord-328753-qwdxgk4z 178 3 Health Health NNP cord-328753-qwdxgk4z 178 4 perspective perspective NN cord-328753-qwdxgk4z 179 1 The the DT cord-328753-qwdxgk4z 179 2 association association NN cord-328753-qwdxgk4z 179 3 between between IN cord-328753-qwdxgk4z 179 4 idiopathic idiopathic JJ cord-328753-qwdxgk4z 179 5 hemolytic hemolytic JJ cord-328753-qwdxgk4z 179 6 uremic uremic JJ cord-328753-qwdxgk4z 179 7 syndrome syndrome NN cord-328753-qwdxgk4z 179 8 and and CC cord-328753-qwdxgk4z 179 9 infection infection NN cord-328753-qwdxgk4z 179 10 by by IN cord-328753-qwdxgk4z 179 11 verotoxin verotoxin NN cord-328753-qwdxgk4z 179 12 - - HYPH cord-328753-qwdxgk4z 179 13 producing produce VBG cord-328753-qwdxgk4z 179 14 Escherichia Escherichia NNP cord-328753-qwdxgk4z 179 15 coli coli NNS cord-328753-qwdxgk4z 179 16 Development Development NNP cord-328753-qwdxgk4z 179 17 of of IN cord-328753-qwdxgk4z 179 18 camelid camelid NNP cord-328753-qwdxgk4z 179 19 single single JJ cord-328753-qwdxgk4z 179 20 chain chain NN cord-328753-qwdxgk4z 179 21 antibodies antibody NNS cord-328753-qwdxgk4z 179 22 against against IN cord-328753-qwdxgk4z 179 23 Shiga Shiga NNP cord-328753-qwdxgk4z 179 24 toxin toxin NN cord-328753-qwdxgk4z 179 25 type type NN cord-328753-qwdxgk4z 179 26 2 2 CD cord-328753-qwdxgk4z 179 27 ( ( -LRB- cord-328753-qwdxgk4z 179 28 Stx2 Stx2 NNP cord-328753-qwdxgk4z 179 29 ) ) -RRB- cord-328753-qwdxgk4z 179 30 with with IN cord-328753-qwdxgk4z 179 31 therapeutic therapeutic JJ cord-328753-qwdxgk4z 179 32 potential potential NN cord-328753-qwdxgk4z 179 33 against against IN cord-328753-qwdxgk4z 179 34 Hemolytic hemolytic JJ cord-328753-qwdxgk4z 179 35 Uremic Uremic NNP cord-328753-qwdxgk4z 179 36 Syndrome Syndrome NNP cord-328753-qwdxgk4z 179 37 ( ( -LRB- cord-328753-qwdxgk4z 179 38 HUS HUS NNP cord-328753-qwdxgk4z 179 39 ) ) -RRB- cord-328753-qwdxgk4z 180 1 A a DT cord-328753-qwdxgk4z 180 2 single single JJ cord-328753-qwdxgk4z 180 3 VHH vhh NN cord-328753-qwdxgk4z 180 4 - - HYPH cord-328753-qwdxgk4z 180 5 based base VBN cord-328753-qwdxgk4z 180 6 toxin toxin NN cord-328753-qwdxgk4z 180 7 - - HYPH cord-328753-qwdxgk4z 180 8 neutralizing neutralize VBG cord-328753-qwdxgk4z 180 9 agent agent NN cord-328753-qwdxgk4z 180 10 and and CC cord-328753-qwdxgk4z 180 11 an an DT cord-328753-qwdxgk4z 180 12 effector effector JJ cord-328753-qwdxgk4z 180 13 antibody antibody NN cord-328753-qwdxgk4z 180 14 protect protect VBP cord-328753-qwdxgk4z 180 15 mice mouse NNS cord-328753-qwdxgk4z 180 16 against against IN cord-328753-qwdxgk4z 180 17 challenge challenge NN cord-328753-qwdxgk4z 180 18 with with IN cord-328753-qwdxgk4z 180 19 Shiga Shiga NNP cord-328753-qwdxgk4z 180 20 toxins toxin NNS cord-328753-qwdxgk4z 180 21 1 1 CD cord-328753-qwdxgk4z 180 22 and and CC cord-328753-qwdxgk4z 180 23 2 2 CD cord-328753-qwdxgk4z 181 1 The the DT cord-328753-qwdxgk4z 181 2 molecular molecular JJ cord-328753-qwdxgk4z 181 3 mechanism mechanism NN cord-328753-qwdxgk4z 181 4 of of IN cord-328753-qwdxgk4z 181 5 Shiga Shiga NNP cord-328753-qwdxgk4z 181 6 toxin toxin NN cord-328753-qwdxgk4z 181 7 Stx2e stx2e NN cord-328753-qwdxgk4z 181 8 neutralization neutralization NN cord-328753-qwdxgk4z 181 9 by by IN cord-328753-qwdxgk4z 181 10 a a DT cord-328753-qwdxgk4z 181 11 single single JJ cord-328753-qwdxgk4z 181 12 - - HYPH cord-328753-qwdxgk4z 181 13 domain domain NN cord-328753-qwdxgk4z 181 14 antibody antibody NN cord-328753-qwdxgk4z 181 15 targeting target VBG cord-328753-qwdxgk4z 181 16 the the DT cord-328753-qwdxgk4z 181 17 cell cell NN cord-328753-qwdxgk4z 181 18 receptor receptor NN cord-328753-qwdxgk4z 181 19 - - HYPH cord-328753-qwdxgk4z 181 20 binding bind VBG cord-328753-qwdxgk4z 181 21 domain domain NN cord-328753-qwdxgk4z 181 22 Listeria listeria NN cord-328753-qwdxgk4z 181 23 - - HYPH cord-328753-qwdxgk4z 181 24 review review NN cord-328753-qwdxgk4z 181 25 of of IN cord-328753-qwdxgk4z 181 26 epidemiology epidemiology NN cord-328753-qwdxgk4z 181 27 and and CC cord-328753-qwdxgk4z 181 28 pathogenesis pathogenesis NN cord-328753-qwdxgk4z 181 29 Structural structural JJ cord-328753-qwdxgk4z 181 30 basis basis NN cord-328753-qwdxgk4z 181 31 of of IN cord-328753-qwdxgk4z 181 32 VHH vhh NN cord-328753-qwdxgk4z 181 33 - - HYPH cord-328753-qwdxgk4z 181 34 mediated mediate VBN cord-328753-qwdxgk4z 181 35 neutralization neutralization NN cord-328753-qwdxgk4z 181 36 of of IN cord-328753-qwdxgk4z 181 37 the the DT cord-328753-qwdxgk4z 181 38 food food NN cord-328753-qwdxgk4z 181 39 - - HYPH cord-328753-qwdxgk4z 181 40 borne bear VBN cord-328753-qwdxgk4z 181 41 pathogen pathogen NN cord-328753-qwdxgk4z 181 42 Listeria Listeria NNP cord-328753-qwdxgk4z 181 43 monocytogenes monocytogenes NNP cord-328753-qwdxgk4z 181 44 High high JJ cord-328753-qwdxgk4z 181 45 affinity affinity NN cord-328753-qwdxgk4z 181 46 anti anti JJ cord-328753-qwdxgk4z 181 47 - - JJ cord-328753-qwdxgk4z 181 48 Internalin internalin JJ cord-328753-qwdxgk4z 181 49 B b NN cord-328753-qwdxgk4z 181 50 VHH vhh NN cord-328753-qwdxgk4z 181 51 antibody antibody NN cord-328753-qwdxgk4z 181 52 fragments fragment NNS cord-328753-qwdxgk4z 181 53 isolated isolate VBN cord-328753-qwdxgk4z 181 54 from from IN cord-328753-qwdxgk4z 181 55 naturally naturally RB cord-328753-qwdxgk4z 181 56 and and CC cord-328753-qwdxgk4z 181 57 artificially artificially RB cord-328753-qwdxgk4z 181 58 immunized immunize VBN cord-328753-qwdxgk4z 181 59 repertoires repertoire NNS cord-328753-qwdxgk4z 181 60 Identification identification NN cord-328753-qwdxgk4z 181 61 and and CC cord-328753-qwdxgk4z 181 62 characterization characterization NN cord-328753-qwdxgk4z 181 63 of of IN cord-328753-qwdxgk4z 181 64 species species NN cord-328753-qwdxgk4z 181 65 - - HYPH cord-328753-qwdxgk4z 181 66 specific specific JJ cord-328753-qwdxgk4z 181 67 nanobodies nanobodie NNS cord-328753-qwdxgk4z 181 68 for for IN cord-328753-qwdxgk4z 181 69 the the DT cord-328753-qwdxgk4z 181 70 detection detection NN cord-328753-qwdxgk4z 181 71 of of IN cord-328753-qwdxgk4z 181 72 Listeria Listeria NNP cord-328753-qwdxgk4z 181 73 monocytogenes monocytogene NNS cord-328753-qwdxgk4z 181 74 in in IN cord-328753-qwdxgk4z 181 75 milk milk NN cord-328753-qwdxgk4z 181 76 Thawing thawing NN cord-328753-qwdxgk4z 181 77 of of IN cord-328753-qwdxgk4z 181 78 permafrost permafrost NN cord-328753-qwdxgk4z 181 79 may may MD cord-328753-qwdxgk4z 181 80 disturb disturb VB cord-328753-qwdxgk4z 181 81 historic historic JJ cord-328753-qwdxgk4z 181 82 cattle cattle NNS cord-328753-qwdxgk4z 181 83 burial burial NN cord-328753-qwdxgk4z 181 84 grounds ground NNS cord-328753-qwdxgk4z 181 85 in in IN cord-328753-qwdxgk4z 181 86 East East NNP cord-328753-qwdxgk4z 181 87 Siberia Siberia NNP cord-328753-qwdxgk4z 181 88 Responding respond VBG cord-328753-qwdxgk4z 181 89 to to IN cord-328753-qwdxgk4z 181 90 the the DT cord-328753-qwdxgk4z 181 91 threat threat NN cord-328753-qwdxgk4z 181 92 of of IN cord-328753-qwdxgk4z 181 93 bioterrorism bioterrorism NN cord-328753-qwdxgk4z 181 94 : : : cord-328753-qwdxgk4z 181 95 a a DT cord-328753-qwdxgk4z 181 96 microbial microbial JJ cord-328753-qwdxgk4z 181 97 ecology ecology NN cord-328753-qwdxgk4z 181 98 perspective perspective NN cord-328753-qwdxgk4z 181 99 - - : cord-328753-qwdxgk4z 181 100 the the DT cord-328753-qwdxgk4z 181 101 case case NN cord-328753-qwdxgk4z 181 102 of of IN cord-328753-qwdxgk4z 181 103 anthrax anthrax NN cord-328753-qwdxgk4z 181 104 Functional functional JJ cord-328753-qwdxgk4z 181 105 analysis analysis NN cord-328753-qwdxgk4z 181 106 of of IN cord-328753-qwdxgk4z 181 107 Bacillus Bacillus NNP cord-328753-qwdxgk4z 181 108 anthracis anthracis NN cord-328753-qwdxgk4z 181 109 protective protective JJ cord-328753-qwdxgk4z 181 110 antigen antigen NN cord-328753-qwdxgk4z 181 111 by by IN cord-328753-qwdxgk4z 181 112 using use VBG cord-328753-qwdxgk4z 181 113 neutralizing neutralize VBG cord-328753-qwdxgk4z 181 114 monoclonal monoclonal JJ cord-328753-qwdxgk4z 181 115 antibodies antibody NNS cord-328753-qwdxgk4z 181 116 A a DT cord-328753-qwdxgk4z 181 117 heterodimer heterodimer NN cord-328753-qwdxgk4z 181 118 of of IN cord-328753-qwdxgk4z 181 119 a a DT cord-328753-qwdxgk4z 181 120 VHH vhh NN cord-328753-qwdxgk4z 181 121 ( ( -LRB- cord-328753-qwdxgk4z 181 122 variable variable JJ cord-328753-qwdxgk4z 181 123 domains domain NNS cord-328753-qwdxgk4z 181 124 of of IN cord-328753-qwdxgk4z 181 125 camelid camelid NN cord-328753-qwdxgk4z 181 126 heavy heavy JJ cord-328753-qwdxgk4z 181 127 chain chain NN cord-328753-qwdxgk4z 181 128 - - HYPH cord-328753-qwdxgk4z 181 129 only only RB cord-328753-qwdxgk4z 181 130 ) ) -RRB- cord-328753-qwdxgk4z 181 131 antibody antibody NN cord-328753-qwdxgk4z 181 132 that that WDT cord-328753-qwdxgk4z 181 133 inhibits inhibit VBZ cord-328753-qwdxgk4z 181 134 anthrax anthrax NN cord-328753-qwdxgk4z 181 135 toxin toxin NN cord-328753-qwdxgk4z 181 136 cell cell NN cord-328753-qwdxgk4z 181 137 binding binding NN cord-328753-qwdxgk4z 181 138 linked link VBN cord-328753-qwdxgk4z 181 139 to to IN cord-328753-qwdxgk4z 181 140 a a DT cord-328753-qwdxgk4z 181 141 VHH VHH NNP cord-328753-qwdxgk4z 181 142 antibody antibody NN cord-328753-qwdxgk4z 181 143 that that WDT cord-328753-qwdxgk4z 181 144 blocks block VBZ cord-328753-qwdxgk4z 181 145 oligomer oligomer NNP cord-328753-qwdxgk4z 181 146 formation formation NN cord-328753-qwdxgk4z 181 147 is be VBZ cord-328753-qwdxgk4z 181 148 highly highly RB cord-328753-qwdxgk4z 181 149 protective protective JJ cord-328753-qwdxgk4z 181 150 in in IN cord-328753-qwdxgk4z 181 151 an an DT cord-328753-qwdxgk4z 181 152 anthrax anthrax NN cord-328753-qwdxgk4z 181 153 spore spore NN cord-328753-qwdxgk4z 181 154 challenge challenge NN cord-328753-qwdxgk4z 181 155 model model NN cord-328753-qwdxgk4z 181 156 A a DT cord-328753-qwdxgk4z 181 157 diverse diverse JJ cord-328753-qwdxgk4z 181 158 set set NN cord-328753-qwdxgk4z 181 159 of of IN cord-328753-qwdxgk4z 181 160 single single JJ cord-328753-qwdxgk4z 181 161 - - HYPH cord-328753-qwdxgk4z 181 162 domain domain NN cord-328753-qwdxgk4z 181 163 antibodies antibody NNS cord-328753-qwdxgk4z 181 164 ( ( -LRB- cord-328753-qwdxgk4z 181 165 VHHs vhh NNS cord-328753-qwdxgk4z 181 166 ) ) -RRB- cord-328753-qwdxgk4z 181 167 against against IN cord-328753-qwdxgk4z 181 168 the the DT cord-328753-qwdxgk4z 181 169 Anthrax Anthrax NNP cord-328753-qwdxgk4z 181 170 toxin toxin NN cord-328753-qwdxgk4z 181 171 lethal lethal JJ cord-328753-qwdxgk4z 181 172 and and CC cord-328753-qwdxgk4z 181 173 edema edema NN cord-328753-qwdxgk4z 181 174 factors factor NNS cord-328753-qwdxgk4z 181 175 provides provide VBZ cord-328753-qwdxgk4z 181 176 a a DT cord-328753-qwdxgk4z 181 177 basis basis NN cord-328753-qwdxgk4z 181 178 for for IN cord-328753-qwdxgk4z 181 179 construction construction NN cord-328753-qwdxgk4z 181 180 of of IN cord-328753-qwdxgk4z 181 181 a a DT cord-328753-qwdxgk4z 181 182 bispecific bispecific NN cord-328753-qwdxgk4z 181 183 agent agent NN cord-328753-qwdxgk4z 181 184 that that WDT cord-328753-qwdxgk4z 181 185 protects protect VBZ cord-328753-qwdxgk4z 181 186 against against IN cord-328753-qwdxgk4z 181 187 Anthrax Anthrax NNP cord-328753-qwdxgk4z 181 188 infection infection NN cord-328753-qwdxgk4z 181 189 Adenoviral Adenoviral NNP cord-328753-qwdxgk4z 181 190 expression expression NN cord-328753-qwdxgk4z 181 191 of of IN cord-328753-qwdxgk4z 181 192 a a DT cord-328753-qwdxgk4z 181 193 bispecific bispecific NN cord-328753-qwdxgk4z 181 194 VHH vhh NN cord-328753-qwdxgk4z 181 195 - - HYPH cord-328753-qwdxgk4z 181 196 Based base VBN cord-328753-qwdxgk4z 181 197 neutralizing neutralize VBG cord-328753-qwdxgk4z 181 198 agent agent NN cord-328753-qwdxgk4z 181 199 that that WDT cord-328753-qwdxgk4z 181 200 targets target VBZ cord-328753-qwdxgk4z 181 201 protective protective JJ cord-328753-qwdxgk4z 181 202 antigen antigen NN cord-328753-qwdxgk4z 181 203 provides provide VBZ cord-328753-qwdxgk4z 181 204 prophylactic prophylactic JJ cord-328753-qwdxgk4z 181 205 protection protection NN cord-328753-qwdxgk4z 181 206 from from IN cord-328753-qwdxgk4z 181 207 Anthrax Anthrax NNP cord-328753-qwdxgk4z 181 208 in in IN cord-328753-qwdxgk4z 181 209 mice mouse NNS cord-328753-qwdxgk4z 182 1 Neurocysticercosis neurocysticercosis NN cord-328753-qwdxgk4z 182 2 : : : cord-328753-qwdxgk4z 182 3 a a DT cord-328753-qwdxgk4z 182 4 major major JJ cord-328753-qwdxgk4z 182 5 cause cause NN cord-328753-qwdxgk4z 182 6 of of IN cord-328753-qwdxgk4z 182 7 neurological neurological JJ cord-328753-qwdxgk4z 182 8 disease disease NN cord-328753-qwdxgk4z 182 9 worldwide worldwide RB cord-328753-qwdxgk4z 182 10 Immunodiagnostic immunodiagnostic JJ cord-328753-qwdxgk4z 182 11 tools tool NNS cord-328753-qwdxgk4z 182 12 for for IN cord-328753-qwdxgk4z 182 13 human human JJ cord-328753-qwdxgk4z 182 14 and and CC cord-328753-qwdxgk4z 182 15 porcine porcine JJ cord-328753-qwdxgk4z 182 16 cysticercosis cysticercosis NN cord-328753-qwdxgk4z 182 17 Nanobodies Nanobodies NNP cord-328753-qwdxgk4z 182 18 , , , cord-328753-qwdxgk4z 182 19 a a DT cord-328753-qwdxgk4z 182 20 promising promising JJ cord-328753-qwdxgk4z 182 21 tool tool NN cord-328753-qwdxgk4z 182 22 for for IN cord-328753-qwdxgk4z 182 23 speciesspecific speciesspecific NN cord-328753-qwdxgk4z 182 24 diagnosis diagnosis NN cord-328753-qwdxgk4z 182 25 of of IN cord-328753-qwdxgk4z 182 26 Taenia Taenia NNP cord-328753-qwdxgk4z 182 27 solium solium NN cord-328753-qwdxgk4z 182 28 cysticercosis cysticercosis NN cord-328753-qwdxgk4z 182 29 Beyond beyond IN cord-328753-qwdxgk4z 182 30 Tsetse Tsetse NNP cord-328753-qwdxgk4z 182 31 - - HYPH cord-328753-qwdxgk4z 182 32 implications implication NNS cord-328753-qwdxgk4z 182 33 for for IN cord-328753-qwdxgk4z 182 34 research research NN cord-328753-qwdxgk4z 182 35 and and CC cord-328753-qwdxgk4z 182 36 control control NN cord-328753-qwdxgk4z 182 37 of of IN cord-328753-qwdxgk4z 182 38 human human JJ cord-328753-qwdxgk4z 182 39 African African NNP cord-328753-qwdxgk4z 182 40 Trypanosomiasis Trypanosomiasis NNP cord-328753-qwdxgk4z 182 41 epidemics epidemic NNS cord-328753-qwdxgk4z 182 42 Nanobodies Nanobodies NNP cord-328753-qwdxgk4z 182 43 as as IN cord-328753-qwdxgk4z 182 44 tools tool NNS cord-328753-qwdxgk4z 182 45 to to TO cord-328753-qwdxgk4z 182 46 understand understand VB cord-328753-qwdxgk4z 182 47 , , , cord-328753-qwdxgk4z 182 48 diagnose diagnose VB cord-328753-qwdxgk4z 182 49 , , , cord-328753-qwdxgk4z 182 50 and and CC cord-328753-qwdxgk4z 182 51 treat treat VB cord-328753-qwdxgk4z 182 52 African African NNP cord-328753-qwdxgk4z 182 53 Trypanosomiasis Trypanosomiasis NNP cord-328753-qwdxgk4z 182 54 Efficient Efficient NNP cord-328753-qwdxgk4z 182 55 targeting targeting NN cord-328753-qwdxgk4z 182 56 of of IN cord-328753-qwdxgk4z 182 57 conserved conserved JJ cord-328753-qwdxgk4z 182 58 cryptic cryptic JJ cord-328753-qwdxgk4z 182 59 epitopes epitope NNS cord-328753-qwdxgk4z 182 60 of of IN cord-328753-qwdxgk4z 182 61 infectious infectious JJ cord-328753-qwdxgk4z 182 62 agents agent NNS cord-328753-qwdxgk4z 182 63 by by IN cord-328753-qwdxgk4z 182 64 single single JJ cord-328753-qwdxgk4z 182 65 domain domain NN cord-328753-qwdxgk4z 182 66 antibodies antibody NNS cord-328753-qwdxgk4z 182 67 . . . cord-328753-qwdxgk4z 183 1 African african JJ cord-328753-qwdxgk4z 183 2 trypanosomes trypanosome NNS cord-328753-qwdxgk4z 183 3 as as IN cord-328753-qwdxgk4z 183 4 paradigm paradigm NN cord-328753-qwdxgk4z 183 5 Nanobody Nanobody NNP cord-328753-qwdxgk4z 183 6 conjugated conjugate VBD cord-328753-qwdxgk4z 183 7 PLGA PLGA NNP cord-328753-qwdxgk4z 183 8 nanoparticles nanoparticle NNS cord-328753-qwdxgk4z 183 9 for for IN cord-328753-qwdxgk4z 183 10 active active JJ cord-328753-qwdxgk4z 183 11 targeting targeting NN cord-328753-qwdxgk4z 183 12 of of IN cord-328753-qwdxgk4z 183 13 African African NNP cord-328753-qwdxgk4z 183 14 Trypanosomiasis Trypanosomiasis NNP cord-328753-qwdxgk4z 183 15 Delivery Delivery NNP cord-328753-qwdxgk4z 183 16 of of IN cord-328753-qwdxgk4z 183 17 a a DT cord-328753-qwdxgk4z 183 18 functional functional JJ cord-328753-qwdxgk4z 183 19 anti anti JJ cord-328753-qwdxgk4z 183 20 - - JJ cord-328753-qwdxgk4z 183 21 trypanosome trypanosome JJ cord-328753-qwdxgk4z 183 22 Nanobody Nanobody NNP cord-328753-qwdxgk4z 183 23 in in IN cord-328753-qwdxgk4z 183 24 different different JJ cord-328753-qwdxgk4z 183 25 tsetse tsetse NN cord-328753-qwdxgk4z 183 26 fly fly VBP cord-328753-qwdxgk4z 183 27 tissues tissue NNS cord-328753-qwdxgk4z 183 28 via via IN cord-328753-qwdxgk4z 183 29 a a DT cord-328753-qwdxgk4z 183 30 bacterial bacterial JJ cord-328753-qwdxgk4z 183 31 symbiont symbiont NN cord-328753-qwdxgk4z 183 32 Generation generation NN cord-328753-qwdxgk4z 183 33 of of IN cord-328753-qwdxgk4z 183 34 a a DT cord-328753-qwdxgk4z 183 35 Nanobody Nanobody NNP cord-328753-qwdxgk4z 183 36 Targeting target VBG cord-328753-qwdxgk4z 183 37 the the DT cord-328753-qwdxgk4z 183 38 Paraflagellar Paraflagellar NNP cord-328753-qwdxgk4z 183 39 Rod Rod NNP cord-328753-qwdxgk4z 183 40 Protein Protein NNP cord-328753-qwdxgk4z 183 41 of of IN cord-328753-qwdxgk4z 183 42 Trypanosomes Trypanosomes NNPS cord-328753-qwdxgk4z 184 1 An an DT cord-328753-qwdxgk4z 184 2 Anti anti JJ cord-328753-qwdxgk4z 184 3 - - JJ cord-328753-qwdxgk4z 184 4 proteome proteome NN cord-328753-qwdxgk4z 184 5 Nanobody Nanobody NNP cord-328753-qwdxgk4z 184 6 Library Library NNP cord-328753-qwdxgk4z 184 7 Approach Approach NNP cord-328753-qwdxgk4z 184 8 Yields yield VBZ cord-328753-qwdxgk4z 184 9 a a DT cord-328753-qwdxgk4z 184 10 Specific specific JJ cord-328753-qwdxgk4z 184 11 Immunoassay immunoassay NN cord-328753-qwdxgk4z 184 12 for for IN cord-328753-qwdxgk4z 184 13 Trypanosoma Trypanosoma NNP cord-328753-qwdxgk4z 184 14 congolense congolense NNP cord-328753-qwdxgk4z 185 1 Diagnosis diagnosis NN cord-328753-qwdxgk4z 185 2 Targeting targeting NN cord-328753-qwdxgk4z 186 1 Glycosomal Glycosomal NNP cord-328753-qwdxgk4z 186 2 Aldolase Aldolase NNP cord-328753-qwdxgk4z 186 3 Structural structural JJ cord-328753-qwdxgk4z 186 4 basis basis NN cord-328753-qwdxgk4z 186 5 for for IN cord-328753-qwdxgk4z 186 6 the the DT cord-328753-qwdxgk4z 186 7 high high JJ cord-328753-qwdxgk4z 186 8 specificity specificity NN cord-328753-qwdxgk4z 186 9 of of IN cord-328753-qwdxgk4z 186 10 a a DT cord-328753-qwdxgk4z 186 11 Trypanosoma Trypanosoma NNP cord-328753-qwdxgk4z 186 12 congolense congolense NN cord-328753-qwdxgk4z 186 13 immunoassay immunoassay NN cord-328753-qwdxgk4z 186 14 targeting target VBG cord-328753-qwdxgk4z 186 15 glycosomal glycosomal NNP cord-328753-qwdxgk4z 186 16 aldolase aldolase NN cord-328753-qwdxgk4z 186 17 Pandemic Pandemic NNP cord-328753-qwdxgk4z 186 18 preparedness preparedness NN cord-328753-qwdxgk4z 186 19 : : : cord-328753-qwdxgk4z 186 20 toward toward IN cord-328753-qwdxgk4z 186 21 a a DT cord-328753-qwdxgk4z 186 22 universal universal JJ cord-328753-qwdxgk4z 186 23 influenza influenza NN cord-328753-qwdxgk4z 186 24 vaccine vaccine NN cord-328753-qwdxgk4z 186 25 Intracellular Intracellular NNP cord-328753-qwdxgk4z 186 26 expression expression NN cord-328753-qwdxgk4z 186 27 of of IN cord-328753-qwdxgk4z 186 28 camelid camelid NNP cord-328753-qwdxgk4z 186 29 single single JJ cord-328753-qwdxgk4z 186 30 - - HYPH cord-328753-qwdxgk4z 186 31 domain domain NN cord-328753-qwdxgk4z 186 32 antibodies antibody NNS cord-328753-qwdxgk4z 186 33 specific specific JJ cord-328753-qwdxgk4z 186 34 for for IN cord-328753-qwdxgk4z 186 35 influenza influenza NNP cord-328753-qwdxgk4z 186 36 virus virus NN cord-328753-qwdxgk4z 186 37 nucleoprotein nucleoprotein NNP cord-328753-qwdxgk4z 186 38 uncovers uncover VBZ cord-328753-qwdxgk4z 186 39 distinct distinct JJ cord-328753-qwdxgk4z 186 40 features feature NNS cord-328753-qwdxgk4z 186 41 of of IN cord-328753-qwdxgk4z 186 42 its -PRON- PRP$ cord-328753-qwdxgk4z 186 43 nuclear nuclear JJ cord-328753-qwdxgk4z 186 44 localization localization NN cord-328753-qwdxgk4z 186 45 Potent potent JJ cord-328753-qwdxgk4z 186 46 neutralization neutralization NN cord-328753-qwdxgk4z 186 47 of of IN cord-328753-qwdxgk4z 186 48 influenza influenza NN cord-328753-qwdxgk4z 186 49 A a DT cord-328753-qwdxgk4z 186 50 virus virus NN cord-328753-qwdxgk4z 186 51 by by IN cord-328753-qwdxgk4z 186 52 a a DT cord-328753-qwdxgk4z 186 53 single single JJ cord-328753-qwdxgk4z 186 54 - - HYPH cord-328753-qwdxgk4z 186 55 domain domain NN cord-328753-qwdxgk4z 186 56 antibody antibody NN cord-328753-qwdxgk4z 186 57 blocking block VBG cord-328753-qwdxgk4z 186 58 M2 M2 NNP cord-328753-qwdxgk4z 186 59 ion ion NN cord-328753-qwdxgk4z 186 60 channel channel NN cord-328753-qwdxgk4z 186 61 protein protein NN cord-328753-qwdxgk4z 186 62 Single Single NNP cord-328753-qwdxgk4z 186 63 - - HYPH cord-328753-qwdxgk4z 186 64 domain domain NN cord-328753-qwdxgk4z 186 65 antibodies antibody NNS cord-328753-qwdxgk4z 186 66 targeting target VBG cord-328753-qwdxgk4z 186 67 neuraminidase neuraminidase NN cord-328753-qwdxgk4z 186 68 protect protect VB cord-328753-qwdxgk4z 186 69 against against IN cord-328753-qwdxgk4z 186 70 an an DT cord-328753-qwdxgk4z 186 71 H5N1 H5N1 NNP cord-328753-qwdxgk4z 186 72 influenza influenza NN cord-328753-qwdxgk4z 186 73 virus virus NN cord-328753-qwdxgk4z 186 74 challenge challenge NN cord-328753-qwdxgk4z 186 75 Llama Llama NNP cord-328753-qwdxgk4z 186 76 - - HYPH cord-328753-qwdxgk4z 186 77 derived derive VBN cord-328753-qwdxgk4z 186 78 single single JJ cord-328753-qwdxgk4z 186 79 domain domain NN cord-328753-qwdxgk4z 186 80 antibodies antibody NNS cord-328753-qwdxgk4z 186 81 to to TO cord-328753-qwdxgk4z 186 82 build build VB cord-328753-qwdxgk4z 186 83 multivalent multivalent JJ cord-328753-qwdxgk4z 186 84 , , , cord-328753-qwdxgk4z 186 85 superpotent superpotent JJ cord-328753-qwdxgk4z 186 86 and and CC cord-328753-qwdxgk4z 186 87 broadened broaden VBD cord-328753-qwdxgk4z 186 88 neutralizing neutralize VBG cord-328753-qwdxgk4z 186 89 anti anti JJ cord-328753-qwdxgk4z 186 90 - - JJ cord-328753-qwdxgk4z 186 91 viral viral JJ cord-328753-qwdxgk4z 186 92 molecules molecule NNS cord-328753-qwdxgk4z 186 93 Nanobodies Nanobodies NNP cord-328753-qwdxgk4z 187 1 With with IN cord-328753-qwdxgk4z 188 1 In in IN cord-328753-qwdxgk4z 188 2 Vitro vitro FW cord-328753-qwdxgk4z 188 3 Neutralizing neutralize VBG cord-328753-qwdxgk4z 188 4 Activity activity NN cord-328753-qwdxgk4z 188 5 Protect protect VBP cord-328753-qwdxgk4z 188 6 Mice mouse NNS cord-328753-qwdxgk4z 188 7 Against against IN cord-328753-qwdxgk4z 188 8 H5N1 H5N1 NNP cord-328753-qwdxgk4z 189 1 Influenza Influenza NNP cord-328753-qwdxgk4z 189 2 Virus Virus NNP cord-328753-qwdxgk4z 189 3 Infection Infection NNP cord-328753-qwdxgk4z 189 4 Global Global NNP cord-328753-qwdxgk4z 189 5 alliance alliance NN cord-328753-qwdxgk4z 189 6 for for IN cord-328753-qwdxgk4z 189 7 rabies rabies NNP cord-328753-qwdxgk4z 189 8 control control NN cord-328753-qwdxgk4z 189 9 partners partner NNS cord-328753-qwdxgk4z 189 10 for for IN cord-328753-qwdxgk4z 189 11 rabies rabies NNP cord-328753-qwdxgk4z 189 12 prevention prevention NN cord-328753-qwdxgk4z 189 13 , , , cord-328753-qwdxgk4z 189 14 estimating estimate VBG cord-328753-qwdxgk4z 189 15 the the DT cord-328753-qwdxgk4z 189 16 global global JJ cord-328753-qwdxgk4z 189 17 burden burden NN cord-328753-qwdxgk4z 189 18 of of IN cord-328753-qwdxgk4z 189 19 endemic endemic JJ cord-328753-qwdxgk4z 189 20 canine canine JJ cord-328753-qwdxgk4z 189 21 rabies rabie NNS cord-328753-qwdxgk4z 190 1 The the DT cord-328753-qwdxgk4z 190 2 cell cell NN cord-328753-qwdxgk4z 190 3 biology biology NN cord-328753-qwdxgk4z 190 4 of of IN cord-328753-qwdxgk4z 190 5 rabies rabies NN cord-328753-qwdxgk4z 190 6 virus virus NN cord-328753-qwdxgk4z 190 7 : : : cord-328753-qwdxgk4z 190 8 using use VBG cord-328753-qwdxgk4z 190 9 stealth stealth NN cord-328753-qwdxgk4z 190 10 to to TO cord-328753-qwdxgk4z 190 11 reach reach VB cord-328753-qwdxgk4z 190 12 the the DT cord-328753-qwdxgk4z 190 13 brain brain NN cord-328753-qwdxgk4z 190 14 Development Development NNP cord-328753-qwdxgk4z 190 15 of of IN cord-328753-qwdxgk4z 190 16 a a DT cord-328753-qwdxgk4z 190 17 mouse mouse NN cord-328753-qwdxgk4z 190 18 monoclonal monoclonal JJ cord-328753-qwdxgk4z 190 19 antibody antibody NN cord-328753-qwdxgk4z 190 20 cocktail cocktail NN cord-328753-qwdxgk4z 190 21 for for IN cord-328753-qwdxgk4z 190 22 post post JJ cord-328753-qwdxgk4z 190 23 - - JJ cord-328753-qwdxgk4z 190 24 exposure exposure JJ cord-328753-qwdxgk4z 190 25 rabies rabies NN cord-328753-qwdxgk4z 190 26 prophylaxis prophylaxis NN cord-328753-qwdxgk4z 190 27 in in IN cord-328753-qwdxgk4z 190 28 humans human NNS cord-328753-qwdxgk4z 190 29 Protective protective JJ cord-328753-qwdxgk4z 190 30 effect effect NN cord-328753-qwdxgk4z 190 31 of of IN cord-328753-qwdxgk4z 190 32 different different JJ cord-328753-qwdxgk4z 190 33 anti anti JJ cord-328753-qwdxgk4z 190 34 - - JJ cord-328753-qwdxgk4z 190 35 rabies rabies JJ cord-328753-qwdxgk4z 190 36 virus virus NN cord-328753-qwdxgk4z 190 37 VHH vhh NN cord-328753-qwdxgk4z 190 38 constructs construct VBZ cord-328753-qwdxgk4z 190 39 against against IN cord-328753-qwdxgk4z 190 40 rabies rabies NN cord-328753-qwdxgk4z 190 41 disease disease NN cord-328753-qwdxgk4z 190 42 in in IN cord-328753-qwdxgk4z 190 43 mice mouse NNS cord-328753-qwdxgk4z 191 1 Post post JJ cord-328753-qwdxgk4z 191 2 - - NN cord-328753-qwdxgk4z 191 3 exposure exposure JJ cord-328753-qwdxgk4z 191 4 Treatment treatment NN cord-328753-qwdxgk4z 191 5 with with IN cord-328753-qwdxgk4z 191 6 anti anti JJ cord-328753-qwdxgk4z 191 7 - - JJ cord-328753-qwdxgk4z 191 8 rabies rabies JJ cord-328753-qwdxgk4z 191 9 VHH vhh NN cord-328753-qwdxgk4z 191 10 and and CC cord-328753-qwdxgk4z 191 11 vaccine vaccine NN cord-328753-qwdxgk4z 191 12 significantly significantly RB cord-328753-qwdxgk4z 191 13 improves improve VBZ cord-328753-qwdxgk4z 191 14 protection protection NN cord-328753-qwdxgk4z 191 15 of of IN cord-328753-qwdxgk4z 191 16 mice mouse NNS cord-328753-qwdxgk4z 191 17 from from IN cord-328753-qwdxgk4z 191 18 lethal lethal JJ cord-328753-qwdxgk4z 191 19 rabies rabies NN cord-328753-qwdxgk4z 191 20 infection infection NN cord-328753-qwdxgk4z 191 21 Outbreak outbreak NN cord-328753-qwdxgk4z 191 22 of of IN cord-328753-qwdxgk4z 191 23 foot foot NN cord-328753-qwdxgk4z 191 24 - - HYPH cord-328753-qwdxgk4z 191 25 and and CC cord-328753-qwdxgk4z 191 26 - - HYPH cord-328753-qwdxgk4z 191 27 mouth mouth NN cord-328753-qwdxgk4z 191 28 disease disease NN cord-328753-qwdxgk4z 191 29 virus virus NN cord-328753-qwdxgk4z 191 30 serotype serotype NN cord-328753-qwdxgk4z 191 31 O o NN cord-328753-qwdxgk4z 191 32 in in IN cord-328753-qwdxgk4z 191 33 the the DT cord-328753-qwdxgk4z 191 34 UK UK NNP cord-328753-qwdxgk4z 191 35 caused cause VBN cord-328753-qwdxgk4z 191 36 by by IN cord-328753-qwdxgk4z 191 37 a a DT cord-328753-qwdxgk4z 191 38 pandemic pandemic NN cord-328753-qwdxgk4z 191 39 strain strain VB cord-328753-qwdxgk4z 191 40 Epidemiological epidemiological JJ cord-328753-qwdxgk4z 191 41 characteristics characteristic NNS cord-328753-qwdxgk4z 191 42 and and CC cord-328753-qwdxgk4z 191 43 financial financial JJ cord-328753-qwdxgk4z 191 44 costs cost NNS cord-328753-qwdxgk4z 191 45 of of IN cord-328753-qwdxgk4z 191 46 the the DT cord-328753-qwdxgk4z 191 47 1997 1997 CD cord-328753-qwdxgk4z 191 48 foot foot NN cord-328753-qwdxgk4z 191 49 - - HYPH cord-328753-qwdxgk4z 191 50 and and CC cord-328753-qwdxgk4z 191 51 - - HYPH cord-328753-qwdxgk4z 191 52 mouth mouth NN cord-328753-qwdxgk4z 191 53 disease disease NN cord-328753-qwdxgk4z 191 54 epidemic epidemic NN cord-328753-qwdxgk4z 191 55 in in IN cord-328753-qwdxgk4z 191 56 Taiwan Taiwan NNP cord-328753-qwdxgk4z 191 57 Molecular Molecular NNP cord-328753-qwdxgk4z 191 58 epidemiology epidemiology NN cord-328753-qwdxgk4z 191 59 of of IN cord-328753-qwdxgk4z 191 60 foot foot NN cord-328753-qwdxgk4z 191 61 - - HYPH cord-328753-qwdxgk4z 191 62 and and CC cord-328753-qwdxgk4z 191 63 - - HYPH cord-328753-qwdxgk4z 191 64 mouth mouth NN cord-328753-qwdxgk4z 191 65 disease disease NN cord-328753-qwdxgk4z 191 66 virus virus NN cord-328753-qwdxgk4z 191 67 Passive passive JJ cord-328753-qwdxgk4z 191 68 immunization immunization NN cord-328753-qwdxgk4z 191 69 with with IN cord-328753-qwdxgk4z 191 70 llama llama NNP cord-328753-qwdxgk4z 191 71 single single JJ cord-328753-qwdxgk4z 191 72 - - HYPH cord-328753-qwdxgk4z 191 73 domain domain NN cord-328753-qwdxgk4z 191 74 antibody antibody NN cord-328753-qwdxgk4z 191 75 fragments fragment NNS cord-328753-qwdxgk4z 191 76 reduces reduce VBZ cord-328753-qwdxgk4z 191 77 foot foot NN cord-328753-qwdxgk4z 191 78 - - HYPH cord-328753-qwdxgk4z 191 79 and and CC cord-328753-qwdxgk4z 191 80 - - HYPH cord-328753-qwdxgk4z 191 81 mouth mouth NN cord-328753-qwdxgk4z 191 82 disease disease NN cord-328753-qwdxgk4z 191 83 transmission transmission NN cord-328753-qwdxgk4z 191 84 between between IN cord-328753-qwdxgk4z 191 85 pigs pig NNS cord-328753-qwdxgk4z 191 86 Characterization characterization NN cord-328753-qwdxgk4z 191 87 of of IN cord-328753-qwdxgk4z 191 88 single single JJ cord-328753-qwdxgk4z 191 89 - - HYPH cord-328753-qwdxgk4z 191 90 domain domain NN cord-328753-qwdxgk4z 191 91 antibodies antibody NNS cord-328753-qwdxgk4z 191 92 against against IN cord-328753-qwdxgk4z 191 93 Foot Foot NNP cord-328753-qwdxgk4z 191 94 and and CC cord-328753-qwdxgk4z 191 95 Mouth Mouth NNP cord-328753-qwdxgk4z 191 96 Disease Disease NNP cord-328753-qwdxgk4z 191 97 Virus Virus NNP cord-328753-qwdxgk4z 191 98 ( ( -LRB- cord-328753-qwdxgk4z 191 99 FMDV FMDV NNP cord-328753-qwdxgk4z 191 100 ) ) -RRB- cord-328753-qwdxgk4z 191 101 serotype serotype NN cord-328753-qwdxgk4z 191 102 O o NN cord-328753-qwdxgk4z 191 103 from from IN cord-328753-qwdxgk4z 191 104 a a DT cord-328753-qwdxgk4z 191 105 camelid camelid NN cord-328753-qwdxgk4z 191 106 and and CC cord-328753-qwdxgk4z 191 107 imaging imaging NN cord-328753-qwdxgk4z 191 108 of of IN cord-328753-qwdxgk4z 191 109 FMDV FMDV NNP cord-328753-qwdxgk4z 191 110 in in IN cord-328753-qwdxgk4z 191 111 baby baby NN cord-328753-qwdxgk4z 191 112 hamster hamster NN cord-328753-qwdxgk4z 191 113 kidney-21 kidney-21 CD cord-328753-qwdxgk4z 191 114 cells cell NNS cord-328753-qwdxgk4z 191 115 with with IN cord-328753-qwdxgk4z 191 116 single single JJ cord-328753-qwdxgk4z 191 117 - - HYPH cord-328753-qwdxgk4z 191 118 domain domain NN cord-328753-qwdxgk4z 191 119 antibody- antibody- NN cord-328753-qwdxgk4z 192 1 quantum quantum JJ cord-328753-qwdxgk4z 192 2 dots dot NNS cord-328753-qwdxgk4z 192 3 probes probes VBP cord-328753-qwdxgk4z 192 4 Specific specific JJ cord-328753-qwdxgk4z 192 5 detection detection NN cord-328753-qwdxgk4z 192 6 of of IN cord-328753-qwdxgk4z 192 7 foot foot NN cord-328753-qwdxgk4z 192 8 - - HYPH cord-328753-qwdxgk4z 192 9 and and CC cord-328753-qwdxgk4z 192 10 - - HYPH cord-328753-qwdxgk4z 192 11 mouth mouth NN cord-328753-qwdxgk4z 192 12 disease disease NN cord-328753-qwdxgk4z 192 13 serotype serotype NN cord-328753-qwdxgk4z 192 14 Asia Asia NNP cord-328753-qwdxgk4z 192 15 1 1 CD cord-328753-qwdxgk4z 192 16 virus virus NN cord-328753-qwdxgk4z 192 17 by by IN cord-328753-qwdxgk4z 192 18 carboxyl carboxyl NN cord-328753-qwdxgk4z 192 19 - - HYPH cord-328753-qwdxgk4z 192 20 magnetic magnetic JJ cord-328753-qwdxgk4z 192 21 beads bead NNS cord-328753-qwdxgk4z 192 22 conjugated conjugate VBN cord-328753-qwdxgk4z 192 23 with with IN cord-328753-qwdxgk4z 192 24 single single JJ cord-328753-qwdxgk4z 192 25 - - HYPH cord-328753-qwdxgk4z 192 26 domain domain NN cord-328753-qwdxgk4z 192 27 antibody antibody NN cord-328753-qwdxgk4z 192 28 Broad broad JJ cord-328753-qwdxgk4z 192 29 diversity diversity NN cord-328753-qwdxgk4z 192 30 of of IN cord-328753-qwdxgk4z 192 31 neutralizing neutralize VBG cord-328753-qwdxgk4z 192 32 antibodies antibody NNS cord-328753-qwdxgk4z 192 33 isolated isolate VBN cord-328753-qwdxgk4z 192 34 from from IN cord-328753-qwdxgk4z 192 35 memory memory NN cord-328753-qwdxgk4z 192 36 B b NN cord-328753-qwdxgk4z 192 37 cells cell NNS cord-328753-qwdxgk4z 192 38 in in IN cord-328753-qwdxgk4z 192 39 HIV HIV NNP cord-328753-qwdxgk4z 192 40 - - HYPH cord-328753-qwdxgk4z 192 41 infected infect VBN cord-328753-qwdxgk4z 192 42 individuals individual NNS cord-328753-qwdxgk4z 192 43 Tackling tackle VBG cord-328753-qwdxgk4z 192 44 influenza influenza NN cord-328753-qwdxgk4z 192 45 with with IN cord-328753-qwdxgk4z 192 46 broadly broadly RB cord-328753-qwdxgk4z 192 47 neutralizing neutralize VBG cord-328753-qwdxgk4z 192 48 antibodies antibody NNS cord-328753-qwdxgk4z 192 49 Recognition Recognition NNP cord-328753-qwdxgk4z 192 50 determinants determinant NNS cord-328753-qwdxgk4z 192 51 of of IN cord-328753-qwdxgk4z 192 52 broadly broadly RB cord-328753-qwdxgk4z 192 53 neutralizing neutralize VBG cord-328753-qwdxgk4z 192 54 human human JJ cord-328753-qwdxgk4z 192 55 antibodies antibody NNS cord-328753-qwdxgk4z 192 56 against against IN cord-328753-qwdxgk4z 192 57 dengue dengue NN cord-328753-qwdxgk4z 192 58 viruses virus NNS cord-328753-qwdxgk4z 192 59 Antibodies antibody NNS cord-328753-qwdxgk4z 192 60 against against IN cord-328753-qwdxgk4z 192 61 MERS MERS NNP cord-328753-qwdxgk4z 192 62 coronavirus coronavirus NN cord-328753-qwdxgk4z 192 63 in in IN cord-328753-qwdxgk4z 192 64 dromedary dromedary NN cord-328753-qwdxgk4z 192 65 camels camel NNS cord-328753-qwdxgk4z 193 1 Seroepidemiology seroepidemiology NN cord-328753-qwdxgk4z 193 2 for for IN cord-328753-qwdxgk4z 193 3 MERS MERS NNP cord-328753-qwdxgk4z 193 4 coronavirus coronavirus NN cord-328753-qwdxgk4z 193 5 using use VBG cord-328753-qwdxgk4z 194 1 microneutralisation microneutralisation NNP cord-328753-qwdxgk4z 194 2 and and CC cord-328753-qwdxgk4z 194 3 pseudoparticle pseudoparticle NNP cord-328753-qwdxgk4z 194 4 virus virus NN cord-328753-qwdxgk4z 194 5 neutralisation neutralisation NN cord-328753-qwdxgk4z 194 6 assays assay NNS cord-328753-qwdxgk4z 194 7 reveal reveal VBP cord-328753-qwdxgk4z 194 8 a a DT cord-328753-qwdxgk4z 194 9 high high JJ cord-328753-qwdxgk4z 194 10 prevalence prevalence NN cord-328753-qwdxgk4z 194 11 of of IN cord-328753-qwdxgk4z 194 12 antibody antibody NN cord-328753-qwdxgk4z 194 13 in in IN cord-328753-qwdxgk4z 194 14 dromedary dromedary NN cord-328753-qwdxgk4z 194 15 camels camel NNS cord-328753-qwdxgk4z 194 16 in in IN cord-328753-qwdxgk4z 194 17 Egypt Egypt NNP cord-328753-qwdxgk4z 194 18 Middle Middle NNP cord-328753-qwdxgk4z 194 19 East East NNP cord-328753-qwdxgk4z 195 1 respiratory respiratory JJ cord-328753-qwdxgk4z 195 2 syndrome syndrome NN cord-328753-qwdxgk4z 195 3 coronavirus coronavirus NN cord-328753-qwdxgk4z 195 4 neutralising neutralise VBG cord-328753-qwdxgk4z 195 5 serum serum NN cord-328753-qwdxgk4z 195 6 antibodies antibody NNS cord-328753-qwdxgk4z 195 7 in in IN cord-328753-qwdxgk4z 195 8 dromedary dromedary NN cord-328753-qwdxgk4z 195 9 camels camel NNS cord-328753-qwdxgk4z 195 10 : : : cord-328753-qwdxgk4z 195 11 a a DT cord-328753-qwdxgk4z 195 12 comparative comparative JJ cord-328753-qwdxgk4z 195 13 serological serological JJ cord-328753-qwdxgk4z 195 14 study study NN cord-328753-qwdxgk4z 195 15 Antibodies antibody NNS cord-328753-qwdxgk4z 195 16 to to IN cord-328753-qwdxgk4z 195 17 hemorrhagic hemorrhagic JJ cord-328753-qwdxgk4z 195 18 fever fever NN cord-328753-qwdxgk4z 195 19 viruses virus NNS cord-328753-qwdxgk4z 195 20 in in IN cord-328753-qwdxgk4z 195 21 domestic domestic JJ cord-328753-qwdxgk4z 195 22 livestock livestock NN cord-328753-qwdxgk4z 195 23 in in IN cord-328753-qwdxgk4z 195 24 Niger Niger NNP cord-328753-qwdxgk4z 195 25 : : : cord-328753-qwdxgk4z 195 26 Rift Rift NNP cord-328753-qwdxgk4z 195 27 Valley Valley NNP cord-328753-qwdxgk4z 195 28 fever fever NN cord-328753-qwdxgk4z 195 29 and and CC cord-328753-qwdxgk4z 195 30 Crimean Crimean NNP cord-328753-qwdxgk4z 195 31 - - HYPH cord-328753-qwdxgk4z 195 32 Congo Congo NNP cord-328753-qwdxgk4z 195 33 hemorrhagic hemorrhagic JJ cord-328753-qwdxgk4z 195 34 fever fever NN cord-328753-qwdxgk4z 195 35 Crimean crimean JJ cord-328753-qwdxgk4z 195 36 Congo Congo NNP cord-328753-qwdxgk4z 195 37 hemorrhagic hemorrhagic JJ cord-328753-qwdxgk4z 195 38 fever fever NN cord-328753-qwdxgk4z 195 39 among among IN cord-328753-qwdxgk4z 195 40 the the DT cord-328753-qwdxgk4z 195 41 one one CD cord-328753-qwdxgk4z 195 42 - - HYPH cord-328753-qwdxgk4z 195 43 humped humped NN cord-328753-qwdxgk4z 195 44 camel camel NN cord-328753-qwdxgk4z 195 45 ( ( -LRB- cord-328753-qwdxgk4z 195 46 Camelus Camelus NNP cord-328753-qwdxgk4z 195 47 dromedaries dromedarie VBZ cord-328753-qwdxgk4z 195 48 ) ) -RRB- cord-328753-qwdxgk4z 195 49 in in IN cord-328753-qwdxgk4z 195 50 Central Central NNP cord-328753-qwdxgk4z 195 51 Sudan Sudan NNP cord-328753-qwdxgk4z 195 52 A a DT cord-328753-qwdxgk4z 195 53 transversal transversal JJ cord-328753-qwdxgk4z 195 54 study study NN cord-328753-qwdxgk4z 195 55 on on IN cord-328753-qwdxgk4z 195 56 antibodies antibody NNS cord-328753-qwdxgk4z 195 57 against against IN cord-328753-qwdxgk4z 195 58 selected select VBN cord-328753-qwdxgk4z 195 59 pathogens pathogen NNS cord-328753-qwdxgk4z 195 60 in in IN cord-328753-qwdxgk4z 195 61 dromedary dromedary NN cord-328753-qwdxgk4z 195 62 camels camel NNS cord-328753-qwdxgk4z 195 63 in in IN cord-328753-qwdxgk4z 195 64 the the DT cord-328753-qwdxgk4z 195 65 Canary Canary NNP cord-328753-qwdxgk4z 195 66 Islands Islands NNPS cord-328753-qwdxgk4z 195 67 Serologic Serologic NNP cord-328753-qwdxgk4z 195 68 survey survey NN cord-328753-qwdxgk4z 195 69 of of IN cord-328753-qwdxgk4z 195 70 viral viral JJ cord-328753-qwdxgk4z 195 71 antibodies antibody NNS cord-328753-qwdxgk4z 195 72 in in IN cord-328753-qwdxgk4z 195 73 the the DT cord-328753-qwdxgk4z 195 74 Peruvian peruvian JJ cord-328753-qwdxgk4z 195 75 alpaca alpaca NN cord-328753-qwdxgk4z 195 76 ( ( -LRB- cord-328753-qwdxgk4z 195 77 Lama Lama NNP cord-328753-qwdxgk4z 195 78 pacos pacos NNP cord-328753-qwdxgk4z 195 79 ) ) -RRB-