id author title date pages extension mime words sentences flesch summary cache txt cord-003615-vpzzsdld Thompson, Kelly B. Late immune consequences of combat trauma: a review of trauma-related immune dysfunction and potential therapies 2019-04-24 .txt text/plain 8886 363 34 Trauma leads to the dysregulation of both the innate and adaptive immune responses, which places the injured at risk for several late consequences, including delayed wound healing, late onset sepsis and infection, multi-organ dysfunction syndrome, and acute respiratory distress syndrome, which are significant for their association with the increased morbidity and mortality of wounded personnel. Patients with less severe trauma may develop late MODS due to new surgical stress, general anesthesia, transfusion of blood products, infection, or ischemia/reperfusion injury triggering the reactivation of the inflammatory response in a "two-hit" model of MODS [19, 58] . Among these consequences, delayed wound healing, late onset sepsis and infection, multi-organ dysfunction syndrome, acute respiratory distress syndrome, and persistent inflammation-immunosuppression and catabolic syndrome are significant in their association with the increased morbidity and mortality of wounded personnel. ./cache/cord-003615-vpzzsdld.txt ./txt/cord-003615-vpzzsdld.txt