id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-005686-k6t1q7q6	Hassett, Patrick	Overexpression of pulmonary extracellular superoxide dismutase attenuates endotoxin-induced acute lung injury	2011-07-14		.txt	text/plain	3763	215	40	title: Overexpression of pulmonary extracellular superoxide dismutase attenuates endotoxin-induced acute lung injury PURPOSE: Superoxide is produced by activated neutrophils during the inflammatory response to stimuli such as endotoxin, can directly or indirectly injure host cells, and has been implicated in the pathogenesis of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). We wished to determine the potential for pulmonary overexpression of the extracellular isoform of superoxide dismutase (EC-SOD) to reduce the severity of endotoxin-induced lung injury. Endotoxin instillation produced a severe lung injury, which was attenuated by EC-SOD overexpression in comparison to animals that received vehicle or null vector. EC-SOD completely attenuated the decrease in static lung compliance (Fig. 2b ) and the increase in peak airway pressure (Fig. 2c) following endotoxin-induced injury. In conclusion, intrapulmonary delivery of EC-SOD decreased the severity of endotoxin-induced lung injury, demonstrating the potential beneficial effects of EC-SOD overexpression in the setting of ALI.	./cache/cord-005686-k6t1q7q6.txt	./txt/cord-005686-k6t1q7q6.txt