id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-010509-gipjuhhc	Xu, Jing	Increased mortality of acute respiratory distress syndrome was associated with high levels of plasma phenylalanine	2020-04-30		.txt	text/plain	5987	327	50	Univariate and multivariate statistical analysis were performed on metabolomic profiles from blood plasma of ARDS patients and healthy controls to screen for "functional metabolites", which were determined by variable importance in projection (VIP) scores and P value. Previous studies have performed metabolomic analysis of plasma, pulmonary edema fluid and bronchoalveolar lavage fluid (BALF) in ARDS patients, preliminarily results revealed a broad range of metabolites that could help in diagnosis and stratify ARDS [3] [4] [5] [6] . Blood plasma samples of patients with ARDS and healthy controls were collected, and metabolomics analysis was conducted to find differential metabolites and altered pathways that are associated with the ARDS mortality. Of note, we showed that the level of Phenylalanine increased in the non-survivors compared to the survivors and we confirmed using a mouse model that Phenylalanine administration increased the lung injury and mortality of mice with ARDS.	./cache/cord-010509-gipjuhhc.txt	./txt/cord-010509-gipjuhhc.txt