id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-011286-8wxih7v6	You, Qinghai	MiR-802 alleviates lipopolysaccharide-induced acute lung injury by targeting Peli2	2019-11-06		.txt	text/plain	4625	323	50	Acute respiratory distress syndrome (ARDS) is a severe lung inflammatory disorder commonly characterized by infection or injury inducing the development of diffuse alveolar damage that results in severe hypoxemia. Macrophages are a key cell type in lung in response to LPS challenge and proinflammatory cytokine production is a critical step that mediates LPSinduced tissue damage. To evaluate the effect of miR-802 on LPS-induced lung acute injury in vivo, the mice were administrated with miR-802 or scramble control intragastrically before being subjected to sepsis challenge. As shown (Fig. 5b) , co-transfection of Peli2 with miR-802 abolished the antagonizing effect of the miRNA on LPS-induced TNFα expression. In ARDS, modified expression of miRNAs has been studied to develop the diagnosis and treatment for a The protein expressions of Peli2 in lung tissues between LPS-induced ARDS model and sham group were compared by ELISA analysis (n = 15, for each group).	./cache/cord-011286-8wxih7v6.txt	./txt/cord-011286-8wxih7v6.txt