id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-011363-o1f398vn	Pitoni, Sara	Tidal Volume Lowering by Instrumental Dead Space Reduction in Brain-Injured ARDS Patients: Effects on Respiratory Mechanics, Gas Exchange, and Cerebral Hemodynamics	2020-04-22		.txt	text/plain	4042	214	48	title: Tidal Volume Lowering by Instrumental Dead Space Reduction in Brain-Injured ARDS Patients: Effects on Respiratory Mechanics, Gas Exchange, and Cerebral Hemodynamics Previous authors highlighted that replacing HME with HH decreases dead space, promotes CO 2 clearance and allows V T and plateau pressure reduction during ARDS [17] [18] [19] [20] : however, no data clarify to what extent ∆P is reduced by this approach and whether this is safe in patients with concomitant brain injury, for whom tight control of PaCO 2 is mandatory and any intervention has to be evaluated also from the perspective of cerebral hemodynamics. The use of HH in patients with brain injury and ARDS reduces instrumental dead space and allows to reduce tidal volume and driving pressure in isocapnic conditions, with no alveolar derecruitment, hypoxemia, changes in cerebral perfusion pressure nor blood flow.	./cache/cord-011363-o1f398vn.txt	./txt/cord-011363-o1f398vn.txt