id author title date pages extension mime words sentences flesch summary cache txt cord-018685-i7s04fh5 Bromberg, Z. Cell Regeneration in Lung Injury 2007 .txt text/plain 3735 229 42 Following injury, regeneration of alveolar epithelial cells proceeds via an organized paradigm where ATII cells and other specific stem cells appear to function as progenitor cells for ATI cells [16 -17] (Fig. 1 ). Cyclin A/cdk2 accumulates during S phase and its activation triggers the transition to G2, a phase characterized by the accumulation of cyclin B/cdc2, which results in the inhibition of DNA replication, cell growth and new protein synthesis [26, 27] The Wnt/␤catenin Cell Signaling Pathway An activated form of q -catenin was expressed in respiratory epithelial cells of the developing lung. Activation of q -catenin caused ectopic differentiation of ATII-like cells in conducting airways, goblet cell hyperplasia, and airspace enlargement, demonstrating a critical role for the Wnt/ q -catenin signal transduction pathway in the differentiation of the respiratory epithelium in the postnatal lung [31] . Pulmonary edema fluid from patients with acute lung injury augments in vitro alveolar epithelial repair by an IL-1beta-dependent mechanism ./cache/cord-018685-i7s04fh5.txt ./txt/cord-018685-i7s04fh5.txt