id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-034469-ew90eef4	Dos Santos Rocha, Andre	Physiologically variable ventilation reduces regional lung inflammation in a pediatric model of acute respiratory distress syndrome	2020-10-31		.txt	text/plain	4840	262	40	Here, we compare structural, molecular and functional outcomes reflecting regional inflammation between PVV and conventional pressure-controlled ventilation (PCV) in a pediatric model of healthy lungs and acute respiratory distress syndrome (ARDS). CONCLUSIONS: Variable ventilation based on a physiological respiratory pattern, compared to conventional pressure-controlled ventilation, reduced global and regional inflammation in both healthy and injured lungs of juvenile rabbits. Conversely, ventilating the lungs with PVV resulted in a significant decrease in tissue damping in control animals (T1-T5, p < 0.01), whereas no change in respiratory mechanics was detected in the ARDS model. In the present study, a combined approach consisting of lung functional and structural assessment was used to investigate differences in the global and regional effects of PVV and the conventional monotonous pressure-controlled mode in a pediatric model of normal lungs and ARDS.	./cache/cord-034469-ew90eef4.txt	./txt/cord-034469-ew90eef4.txt