id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-254083-ea94wn3f	Fowler, Alexander J.	COVID-19 Phenotypes and Potential Harm of Conventional Treatments: How to Prove the Hypothesis	2020-08-15		.txt	text/plain	1731	87	40	We appreciate the authors' clinical observations and their expertise; however, we have several concerns with these two recommendations, which diverge from the best established evidence for acute respiratory distress syndrome (ARDS). For reference, patients enrolled in the PROSEVA (Prone Positioning in Severe ARDS) trial had a mean respiratory system compliance of 35 ml/cm H 2 O (SD, 15) at the time of enrollment (3). Evidence from randomized controlled trials suggests that prone positioning and low VT ventilation are the precise strategies for gentle ventilation that patients with ARDS, "typical" or not, should receive. Importantly, the authors suggest that recommended treatment strategies for severe COVID-19 pneumonia based on ARDS management (3) may lead to disease progression and excess harm (1, 2) . Second, we can use the DAG to determine a minimal adjustment set of variables to reliably estimate the direct effect of our exposure (ARDS ventilation strategy in COVID-19 L-phenotype patients) and outcome (ICU mortality).	./cache/cord-254083-ea94wn3f.txt	./txt/cord-254083-ea94wn3f.txt