id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-260577-t4w4pw12	Imai, Yumiko	The renin–angiotensin system in acute respiratory distress syndrome	2006-08-07		.txt	text/plain	2978	170	50	The importance of RAS in acute respiratory distress syndrome (ARDS) has recently re-emerged owing to the identification of ACE2 as a receptor for the SARS-coronavirus. Recent studies have demonstrated that ACE2 protects mice from acute lung injury as well as SARS-mediated lung injury. Angiotensin-converting enzyme (ACE) and ACE2 share homology in their catalytic domain and provide different key functions in the renin-angiotensin system (RAS). The importance of the RAS in acute respiratory distress syndrome (ARDS) has recently re-emerged owing to the identification of ACE2 as a receptor for the severe acute respiratory syndrome-coronavirus (SARS-CoV) [5] . Importantly, the treatment with catalytically active, but not enzymatically inactive, recombinant ACE2 protein improved the symptoms of acute lung injury in wild type mice as well as in ace2 knockout mice, suggesting ACE2 protein as a possible novel therapeutic target for ARDS (Fig. 2) . A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury	./cache/cord-260577-t4w4pw12.txt	./txt/cord-260577-t4w4pw12.txt