id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-266067-wrouqdcj	Haywood, Nathan	Isolated Lung Perfusion in the Management of Acute Respiratory Distress Syndrome	2020-09-17		.txt	text/plain	6939	348	44	The ability of EVLP to rehabilitate lungs injured in a porcine sepsis model [21] has provided the basis for a similar application-the use of isolated lung perfusion in vivo in the management of ARDS. Here, early animal studies have demonstrated the ability of in vivo lung perfusion (IVLP) to rehabilitate sepsis-induced ARDS [22] . Below, we review the history and current evidence for isolated lung perfusion techniques, with a focus on how EVLP has provided the basis for and led to investigations into the use of IVLP for the treatment of ARDS. Using both murine and porcine models, we have demonstrated that the addition of a selective adenosine 2A receptor (A2AR) agonist to the EVLP perfusate is associated with less pulmonary edema, lower levels of pro-inflammatory cytokines, and improved lung function [43, 44] .	./cache/cord-266067-wrouqdcj.txt	./txt/cord-266067-wrouqdcj.txt