id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-277788-6ls21tkr	Nelson, Brian C	Clinical Outcomes Associated with Methylprednisolone in Mechanically Ventilated Patients with COVID-19	2020-08-09		.txt	text/plain	3554	216	49	METHODS: Clinical outcomes associated with the use of methylprednisolone were assessed in an unmatched, case-control study; a subset of patients also underwent propensity-score matching. Our study evaluated the association of methylprednisolone treatment with duration of mechanical ventilation and mortality in intubated, critically-ill patients with COVID-19. We observed an increase in the number of ventilator-free days and the likelihood of extubation, as well as a statistically non-significant trend towards improved mortality, in the corticosteroid group when compared to control patients in a propensity-matched cohort by day 28. Although this benefit was greatest in the subset of patients that required mechanical ventilation, the trial only evaluated outcomes through hospital day 28 and did not assess other corticosteroids, such as methylprednisolone [14] . We found that treatment with methylprednisolone increased the number of ventilator-free days and probability of extubation compared with a propensity matched control group among patients with severe COVID-19 requiring mechanical ventilation, but we did not detect a significant difference in mortality.	./cache/cord-277788-6ls21tkr.txt	./txt/cord-277788-6ls21tkr.txt