id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-278249-vvhq9vgp	Blot, Mathieu	CXCL10 could drive longer duration of mechanical ventilation during COVID-19 ARDS	2020-11-02		.txt	text/plain	6238	346	45	In addition, since most patients need to undergo mechanical ventilation in this context, ventilator-induced lung injury (VILI) could exacerbate tissue damage as well as local and systemic inflammation, thus acting as a "second hit." Our team has previously shown that mitochondrial alarmins (i.e., mitochondrial DNA) are released by human epithelial cells submitted to cyclic stretch, and these alarmins are also recovered from bronchoalveolar lavage (BAL) fluid obtained from either ventilated rabbits or ARDS patients. This comprehensive evaluation of systemic and pulmonary immune response showed that the higher CXCL10 concentrations in both the systemic and alveolar compartments of patients with COVID-19 ARDS were associated with a longer duration of mechanical ventilation. Finally, in both COVID-19 and non-COVID-19 patients, higher mitochondrial DNA concentrations in the plasma and ELF compartment were highly correlated with alveolar inflammation, as assessed by BALF cell count and ELF IL-8 and IL-1β concentrations.	./cache/cord-278249-vvhq9vgp.txt	./txt/cord-278249-vvhq9vgp.txt