id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-279440-0mn5b0vv	Diehl, J-L	Response to Damiani and colleagues	2020-10-14		.txt	text/plain	882	46	43	have put our results in perspective with their own published observations of an inverse relationship between sublingual perfused vessel density and D-dimers in mechanically ventilated patients with severe SARS-CoV-2 pneumonia. To explore if COVID-19 ARDS patients could exhibit a lung-specific microvascular response to high PEEP levels, as compared to non-COVID-19 ARDS patients, seems to be an important field of investigation. One important point is that the very vast majority of studies in COVID-19 ARDS patients used, by convenience, ventilatory ratio (VR) as a marker of impaired ventilatory efficacy, as mentioned in Damiani's comment, rather than dead space measurements. Finally, it will be important to further precisely investigate the relationship between dead space measurements, with a special focus on indicators of alveolar dead space, and markers of endothelial dysfunction, such as bio-markers (such as CECs and D-dimers) and innovative methods such as the video-microscopy methods used by Damiani and colleagues.	./cache/cord-279440-0mn5b0vv.txt	./txt/cord-279440-0mn5b0vv.txt