id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-283780-h4lwzpl9	Zhang, John J Y	Risk Factors of Severe Disease and Efficacy of Treatment in Patients Infected with COVID-19: A Systematic Review, Meta-Analysis and Meta-Regression Analysis	2020-05-14		.txt	text/plain	3118	221	50	title: Risk Factors of Severe Disease and Efficacy of Treatment in Patients Infected with COVID-19: A Systematic Review, Meta-Analysis and Meta-Regression Analysis We conducted a systematic review and meta-analysis of all published studies up to March 15, 2020 which reported COVID-19 clinical features and/or treatment outcomes. To address this gap in the literature, we conducted a systematic review, meta-analysis and meta-regression to 1) investigate the predictive value of laboratory investigations for severe disease and adverse outcomes, and 2) evaluate the efficacy of antivirals and corticosteroids for COVID-19. Among the patients with antiviral use reported in our meta-analysis, overall rates of mortality, ICU admission and ARDS were 5.7%, 11.8% and 20.2%, respectively. Our meta-analysis suggested that the use of corticosteroids is associated with disease severity (ICU admission) and higher ARDS rates. To the best of our knowledge, this is the first systematic review and meta-analysis of COVID-19 to describe specific laboratory predictors of severe disease and adverse outcomes.	./cache/cord-283780-h4lwzpl9.txt	./txt/cord-283780-h4lwzpl9.txt