id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-285684-iiqyzqsb	Li, Jin-ze	Mechanically Stretched Mesenchymal Stem Cells Can Reduce the Effects of LPS-Induced Injury on the Pulmonary Microvascular Endothelium Barrier	2020-10-30		.txt	text/plain	4623	256	46	title: Mechanically Stretched Mesenchymal Stem Cells Can Reduce the Effects of LPS-Induced Injury on the Pulmonary Microvascular Endothelium Barrier The aim of this study was to evaluate the potential therapeutic effects of MS-MSCs on pulmonary microvascular endothelium barrier injuries induced by LPS. These data demonstrated that the MS-MSC groups had potential therapeutic effects on the LPS-treated ECs; these results might be useful in the treatment of ARDS. We introduced a transwell coculture system to evaluate the effects of MS-MSCs on the paracellular permeability of LPS-treated ECs. Treatment with LPS significantly increased the paracellular permeabil-ity of the pulmonary microvascular endothelium barrier (Figure 6 (a); * * p < 0:01). We demonstrated that mechanical stretch could impact MSC morphology and biological function in a time-and magnitude-dependent manner and that MS-MSCs could restored the increased permeability of endothelial cells induced by LPS. In this study, we tried to discover evidences of mechanically stretched MSCs in restoring increased permeability of endothelial barrier induced by LPS.	./cache/cord-285684-iiqyzqsb.txt	./txt/cord-285684-iiqyzqsb.txt