id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-291481-ov1gkgpc	Bonizzoli, Manuela	Human herpesviruses respiratory infections in patients with acute respiratory distress (ARDS)	2016-05-02		.txt	text/plain	4998	249	45	In patients requiring mechanical ventilation, herpesviruses, mainly HSV1 and hCMV, may be frequently detected from either upper or lower respiratory tract Abstract Acute respiratory distress syndrome (ARDS) is today a leading cause of hospitalization in intensive care unit (ICU). A higher ICU mortality was significantly related to the presence of herpesvirus infection in the lower respiratory tract as well as to impaired immunophenotype, as patients with poor outcome showed severe lymphopenia, affecting in particular T (CD3+) cells, since the first days of ICU hospitalization. One hundred and eight clinical samples from upper and lower respiratory tract from the 54 ICU patients were analyzed to detect influenza and other respiratory viruses and a group of herpesviruses (EBV, hCMV and HSV1). This report concerns a group of 54 patients admitted to ICU because of ARDS with unknown causative agent; 19 of them were infected by influenza virus, as demonstrated by the detection of viral RNA in both upper and lower respiratory tract samples.	./cache/cord-291481-ov1gkgpc.txt	./txt/cord-291481-ov1gkgpc.txt