id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-293736-nyvwv31m	Méry, Geoffroy	COVID-19: Underlying Adipokine Storm and Angiotensin 1-7 Umbrella	2020-07-21		.txt	text/plain	5746	268	39	Here we seek to explore what underlies the link between immune response and respiratory failure in CoV infections on the one hand, and the current observation of obesity as a risk factor for severe outcome in COVID-19 on the other. Indeed, during COVID-19 infection, most patients exhibit a specific cytokine profile, associating innate immunity chemokines (such as monocyte chemoattractant protein 3 and interferon gamma-induced protein 10 (IP-10), which are suggestive of macrophage activation and epithelial suffering), and pro-inflammatory macrophage-produced cytokines such as IL-6 (45). We suggest that the tampering with such pathways could also lead to abnormalities in the inflammatory response observed in severe CoV infections through their influence on immune regulation and cytokine production. Besides suffering from a pro-inflammatory environment, which favors macrophage activation and neutrophil production, obese patients exhibit abnormal responses to viral infection.	./cache/cord-293736-nyvwv31m.txt	./txt/cord-293736-nyvwv31m.txt