id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-309089-ex9nh1yi	Coperchini, Francesca	The Cytokine storm in COVID-19: An overview of the involvement of the chemokine/chemokine-receptor system	2020-05-11		.txt	text/plain	6132	303	43	Since the first reports on COVID-19 disease, it appeared clear that Acute respiratory distress syndrome (ARDS) accounted for a significant number of deaths among infected patients and that ARDS should be regarded as the hallmark immune-mediated clinical consequence in SARS-CoV-2, similarly to what described for SARS-CoV and MERS-CoV infections [11] . As shown by previous data in the literature, increased circulating levels of pro-inflammatory cytokines (eg, Interferon γ, interleukin (IL-) 1B, IL-6, IL-12) and chemokines (CXCL10, and CCL2) are associated with pulmonary inflammation and extensive lung involvement in SARS patients, similarly to what happens in MERS-CoV infection [13] . In mice infected with SARS-CoV, the clinical features of the syndrome showed an age-dependent increase in severity (similarly to what observed in humans), which was related to an increased level of pro-inflammatory cytokines and chemokines, paralleled by a reduction in T-cell responses [78] .	./cache/cord-309089-ex9nh1yi.txt	./txt/cord-309089-ex9nh1yi.txt