id author title date pages extension mime words sentences flesch summary cache txt cord-321499-17n9tj70 Marini, John J. Integrating the evidence: confronting the COVID-19 elephant 2020-07-25 .txt text/plain 1707 104 46 The acute respiratory distress syndrome (ARDS) that figures so prominently in severe cases of COVID infection may seem familiar but has historically predisposed to such logical missteps [6] . This simple perception provided for adult patients a convenient explanation that paralleled that of the infant respiratory distress syndrome, a condition for which the root cause mechanism had already been confirmed [8] . As pathologic severity increases, key definitional features of ARDS (extensive infiltrates, hypoxemia) usually proceed in synch, serving to guide clinical treatment and prognosis by gas exchange criteria. Respiratory system compliance is not invariably low in the presence of severe hypoxemia Do patients progress to diffuse airspace disease via patient self-inflicted lung injury (PSILI)? Covid-19 does not lead to a "typical" acute respiratory distress syndrome Management of Covid-19 respiratory distress Potential for lung recruitment and ventilation-perfusion mismatch in patients with the acute respiratory distress syndrome from coronavirus disease 2019 ./cache/cord-321499-17n9tj70.txt ./txt/cord-321499-17n9tj70.txt