id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-324232-nupi7f72	Villar, Jesús	Rationale for Prolonged Corticosteroid Treatment in the Acute Respiratory Distress Syndrome Caused by Coronavirus Disease 2019	2020-04-29		.txt	text/plain	2369	127	38	The analysis to support the Task Force's recommendations was limited to nine randomized controlled trials (RCTs) that investigated methylprednisolone (n = 322) (7) and hydrocortisone (n = 494) treatment in ARDS for a duration of at least 7 days. Clinical investigators in Spain recently completed a large confirmatory RCT (Efficacy Study of Dexamethasone to Treat the Acute Respiratory Distress Syndrome [DEXA-ARDS]) enrolling 277 patients with moderate-to-severe ARDS and receiving LTV ventilation (6) . Second, they ignored the positive findings of two large studies (5,327 patients with severe acute respiratory syndrome [SARS] [24] and 2,141 patients with influenza H1N1 pneumonia [25] ) that evaluated the impact of time, dose, and duration of CST and reported a significant reduction in mortality with dosage and duration similar to the one recommended by SCCM and ESICM Task Force (5) .	./cache/cord-324232-nupi7f72.txt	./txt/cord-324232-nupi7f72.txt