id author title date pages extension mime words sentences flesch summary cache txt cord-325408-uy5ew3ki Singer, Benjamin D. A Call for Rational Intensive Care in the Era of COVID-19 2020-07-17 .txt text/plain 1609 91 48 As intensive care physicians, we have been trained to treat viral pneumonia and its attendant complications of acute respiratory distress syndrome (ARDS) and multiorgan failure. In fact, the patients enrolled in the ARMA (Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress) trial of low-tidal-volume ventilation and the PROSEVA (Proning Severe ARDS Patients) trial of prone positioning exhibited myriad etiologies, compliances, and shunt fractions but nevertheless benefited from the targeted interventions (4, 5) . Currently, numerous agents are being administered to patients with COVID-19 outside of controlled trials, including hydroxychloroquine, azithromycin, doxycycline, remdesivir, lopinavir-ritonavir, heparin, low-molecular-weight heparin, tissue plasminogen activator, glucocorticoids, tocilizumab, eculizumab, IFN-b, IFN-g, IL-1 inhibitors, mesenchymal stem cells, convalescent plasma, nitric oxide, vitamin C, and others. We show in the present study that severe RSV infection in infants is associated with a marked upregulation of CD32 on T cells. ./cache/cord-325408-uy5ew3ki.txt ./txt/cord-325408-uy5ew3ki.txt