id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-326805-c5co9cfq	Lin, Shi-hui	Coronavirus Disease 2019 (COVID-19): Cytokine Storms, Hyper-Inflammatory Phenotypes, and Acute Respiratory Distress Syndrome	2020-06-29		.txt	text/plain	1361	100	46	title: Coronavirus Disease 2019 (COVID-19): Cytokine Storms, Hyper-Inflammatory Phenotypes, and Acute Respiratory Distress Syndrome Cytokine storms are a pathophysiological feature of COVID-19 and play an important role in distinguishing hyper-inflammatory subphenotypes of ARDS. Furthermore, we discuss inflammation-related indicators that have the potential to identify hyper-inflammatory subphenotypes of COVID-19, especially for those with a high risk of ARDS. [12, 27] Furthermore, other observational COVID-19 studies have suggested that cytokine 4 storms (comprised of IL-1β, IL-1RA, IL-7, and IL-8) may be associated with disease severity.[7, 12, 5 28] For example, higher concentrations of granulocyte colony-stimulating factor (GCSF), IP10, 6 MCP1, MIP1A, and TNF-α were found in patients who required admission into an intensive care 7 unit (ICU). In COVID-19, there is also suggestive evidence of hyper-inflammatory subphenotypes of ARDS. Circulating IL-1ra and 42 IL-10 levels are increased but do not predict the development of acute respiratory distress 43 syndrome in at-risk patients	./cache/cord-326805-c5co9cfq.txt	./txt/cord-326805-c5co9cfq.txt