id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-329585-uyze6dtu	Earhart, Alexander P.	Consideration of dornase alfa for the treatment of severe COVID-19 ARDS	2020-04-30		.txt	text/plain	720	50	42	The cellular and molecular mechanism proposed for dornase alfa activity in severely distressed lungs of CF and many ARDS patients is as follows. Inflammation results in neutrophilia and neutrophil infiltration in the lungs, where these cells produce NETs, largely comprised of sticky, large chromosomal DNA that physically reinforces airway mucus viscosity and accumulation (5, 6) . Dornase alfa facilitates airway clearance by breaking up reinforcement of mucus by NETs, by far the greatest source of extracellular DNA in inflamed lungs (5, 6) . Indeed, lung neutrophilia and NET production have been shown to contribute to the development of ARDS in other severe viral respiratory infections, including H1N1 influenza (11) . We postulate that nebulized dornase alfa may effectively treat a deleterious effect of NETs in the airways and thus promote recovery in patients with COVID-19-related ARDS ( Figure 1 ). Model of how dornase alfa-sensitive NETs from neutrophils may reinforce mucus accumulation, rigidity, and airway occlusion in severe COVID-19.	./cache/cord-329585-uyze6dtu.txt	./txt/cord-329585-uyze6dtu.txt