id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-329985-5rji08p7	Robba, Chiara	Distinct phenotypes require distinct respiratory management strategies in severe COVID-19	2020-05-11		.txt	text/plain	4382	220	42	The abnormalities observed on chest computed tomography (CT) and the clinical presentation of COVID-19 patients are not always like those of typical acute respiratory distress syndrome (ARDS) and can change over time. Few data are available on the efficacy of noninvasive support-which includes continuous positive airway pressure (CPAP), noninvasive ventilation (NIV), and high flow nasal oxygen (HFNO)-in COVID-19 pneumonia. When hypoxemia and respiratory failure persist or worsen after oxygen therapy or within a short time (1 hour) of placement of HFNO or NIV support, or in case of persistent hypercapnia, organ failure, coma, risk or aspiration, or hemodynamic instability, invasive mechanical ventilation should J o u r n a l P r e -p r o o f be implemented as soon as possible (Fig. 2) . As noted above, we have found that chest CT findings in COVID-19 fall into three different phenotypes, each warranting unique mechanical ventilation settings and management strategies, which should thus be individualized based on clinical and CT features (Fig. 1, Additional File 1, Fig. S1 ).	./cache/cord-329985-5rji08p7.txt	./txt/cord-329985-5rji08p7.txt