id author title date pages extension mime words sentences flesch summary cache txt cord-344829-adlp2rjy de Rivero Vaccari, Juan Carlos The Inflammasome in Times of COVID-19 2020-10-08 .txt text/plain 8722 423 37 Here we review the literature regarding the mechanism of inflammasome activation by CoV infection, the role of the inflammasome in ARDS, ventilator-induced lung injury (VILI), and Disseminated Intravascular Coagulation (DIC) as well as the potential mechanism by which the inflammasome may contribute to the damaging effects of inflammation in the cardiac, renal, digestive, and nervous systems in COVID-19 patients. Here we review the literature on the role of the inflammasome in CoV infections, which includes how CoVs activate inflammasomes upon infection, the role of the inflammasome in acute respiratory distress syndrome (ARDS), how ventilator-induced lung injury (VILI) activates the inflammasome, how the inflammasome plays a role in the systemic complications associated with COVID-19, and how the inflammasome is involved in the process of Disseminated Intravascular Coagulation (DIC). ./cache/cord-344829-adlp2rjy.txt ./txt/cord-344829-adlp2rjy.txt