id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-346230-39oo7vnq	Byrne, J. D.	Prophylaxis with tetracyclines in ARDS: Potential therapy for COVID-19-induced ARDS?	2020-07-28		.txt	text/plain	1441	95	35	Here, we present a retrospective multi-institutional cohort study evaluating ventilatory status in patients who had taken a tetracycline antibiotic within a year prior to diagnosis of acute respiratory distress syndrome (ARDS). Minocycline or doxycycline treatment within a year prior to ARDS diagnosis was associated with a 75% reduced likelihood for mechanical ventilation during hospital stay. In this retrospective multi-institutional cohort study, we aimed to assess whether prophylactic use of either minocycline, doxycycline, or tetracycline could reduce the concomitant requirement for ventilatory support and duration of ICU stay among ARDS patients. Minocycline (p = 0.037) or doxycycline (p = 0.035) treatment within a year prior to ARDS diagnosis was associated with a 75% reduced likelihood for mechanical ventilation during hospital stay (Figure 1, A) . Similarly, treatment effects regression modeling indicated that minocycline (p = 0.004), doxycycline (p = 0.04), and tetracycline (p < 0.001) therapy corresponded to significant reductions in duration of mechanical ventilation in ARDS patients.	./cache/cord-346230-39oo7vnq.txt	./txt/cord-346230-39oo7vnq.txt