id author title date pages extension mime words sentences flesch summary cache txt cord-349201-d88g5toc Yu, Feng Exploring the biomarkers associated with different host inflammation of acute respiratory distress syndrome (ARDS) from lung metabolomics in mice 2020-10-13 .txt text/plain 6149 349 47 title: Exploring the biomarkers associated with different host inflammation of acute respiratory distress syndrome (ARDS) from lung metabolomics in mice RATIONALE: The aim of this study was to analyze the metabolomics of lung with different host inflammation of acute respiratory distress syndrome (ARDS) for the identification of biomarkers for predicting severity under different inflammatory conditions. RF analysis of lung-targeted metabolomics data defined a set of 15 metabolites that constitute the best predictors of differences in host inflammation status: in particular, increased 4hydroxyphenylacetic acid, 1-aminocyclopentanecarboxylic acid (ACPC), and cis-aconitic acid, Tridecane and hydroxybenzoic acid were strong predictors of the hyper-inflammatory subgroup in CLP-induced ALI ( Figure 3B ). Interestingly, RF analysis of lung-targeted metabolomics data showed that the metabolic biomarker group with 5 products was a strong predictor of the hyper-inflammatory subgroup in CLP-induced ALI ( Figure 3B ). ./cache/cord-349201-d88g5toc.txt ./txt/cord-349201-d88g5toc.txt