id	sid	tid	token	lemma	pos
cord-005941-e4fvj54l	1	1	key	key	NN
cord-005941-e4fvj54l	1	2	:	:	:
cord-005941-e4fvj54l	2	1	cord-005941-e4fvj54l	cord-005941-e4fvj54l	NNP
cord-005941-e4fvj54l	3	1	authors	author	NNS
cord-005941-e4fvj54l	3	2	:	:	:
cord-005941-e4fvj54l	3	3	Hamm	Hamm	NNP
cord-005941-e4fvj54l	3	4	,	,	,
cord-005941-e4fvj54l	3	5	H.	H.	NNP
cord-005941-e4fvj54l	3	6	;	;	:
cord-005941-e4fvj54l	3	7	Fabel	Fabel	NNP
cord-005941-e4fvj54l	3	8	,	,	,
cord-005941-e4fvj54l	3	9	H.	H.	NNP
cord-005941-e4fvj54l	3	10	;	;	:
cord-005941-e4fvj54l	3	11	Bartsch	Bartsch	NNP
cord-005941-e4fvj54l	3	12	,	,	,
cord-005941-e4fvj54l	3	13	W.	W.	NNP
cord-005941-e4fvj54l	3	14	title	title	NN
cord-005941-e4fvj54l	3	15	:	:	:
cord-005941-e4fvj54l	3	16	The	the	DT
cord-005941-e4fvj54l	3	17	surfactant	surfactant	NN
cord-005941-e4fvj54l	3	18	system	system	NN
cord-005941-e4fvj54l	3	19	of	of	IN
cord-005941-e4fvj54l	3	20	the	the	DT
cord-005941-e4fvj54l	3	21	adult	adult	NN
cord-005941-e4fvj54l	3	22	lung	lung	NN
cord-005941-e4fvj54l	3	23	:	:	:
cord-005941-e4fvj54l	3	24	physiology	physiology	NN
cord-005941-e4fvj54l	3	25	and	and	CC
cord-005941-e4fvj54l	3	26	clinical	clinical	JJ
cord-005941-e4fvj54l	3	27	perspectives	perspective	NNS
cord-005941-e4fvj54l	3	28	date	date	NN
cord-005941-e4fvj54l	3	29	:	:	:
cord-005941-e4fvj54l	3	30	1992	1992	CD
cord-005941-e4fvj54l	3	31	journal	journal	NN
cord-005941-e4fvj54l	3	32	:	:	:
cord-005941-e4fvj54l	3	33	Clin	Clin	NNP
cord-005941-e4fvj54l	3	34	Investig	Investig	NNP
cord-005941-e4fvj54l	3	35	DOI	DOI	NNP
cord-005941-e4fvj54l	3	36	:	:	:
cord-005941-e4fvj54l	4	1	10.1007	10.1007	CD
cord-005941-e4fvj54l	4	2	/	/	SYM
cord-005941-e4fvj54l	4	3	bf00180279	bf00180279	NNP
cord-005941-e4fvj54l	4	4	sha	sha	NNP
cord-005941-e4fvj54l	4	5	:	:	:
cord-005941-e4fvj54l	4	6	ef5b51f7571c395231fd93b47e192b053c207f37	ef5b51f7571c395231fd93b47e192b053c207f37	NNP
cord-005941-e4fvj54l	4	7	doc_id	doc_id	NNP
cord-005941-e4fvj54l	4	8	:	:	:
cord-005941-e4fvj54l	4	9	5941	5941	CD
cord-005941-e4fvj54l	4	10	cord_uid	cord_uid	NNS
cord-005941-e4fvj54l	4	11	:	:	:
cord-005941-e4fvj54l	5	1	e4fvj54l	e4fvj54l	DT
cord-005941-e4fvj54l	5	2	Pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	5	3	surfactant	surfactant	NN
cord-005941-e4fvj54l	5	4	is	be	VBZ
cord-005941-e4fvj54l	5	5	synthesized	synthesize	VBN
cord-005941-e4fvj54l	5	6	and	and	CC
cord-005941-e4fvj54l	5	7	secreted	secrete	VBN
cord-005941-e4fvj54l	5	8	by	by	IN
cord-005941-e4fvj54l	5	9	alveolar	alveolar	JJ
cord-005941-e4fvj54l	5	10	type	type	NN
cord-005941-e4fvj54l	5	11	II	ii	CD
cord-005941-e4fvj54l	5	12	cells	cell	NNS
cord-005941-e4fvj54l	5	13	and	and	CC
cord-005941-e4fvj54l	5	14	constitutes	constitute	VBZ
cord-005941-e4fvj54l	5	15	an	an	DT
cord-005941-e4fvj54l	5	16	important	important	JJ
cord-005941-e4fvj54l	5	17	component	component	NN
cord-005941-e4fvj54l	5	18	of	of	IN
cord-005941-e4fvj54l	5	19	the	the	DT
cord-005941-e4fvj54l	5	20	alveolar	alveolar	NN
cord-005941-e4fvj54l	5	21	lining	lining	NN
cord-005941-e4fvj54l	5	22	fluid	fluid	NN
cord-005941-e4fvj54l	5	23	.	.	.
cord-005941-e4fvj54l	6	1	It	-PRON-	PRP
cord-005941-e4fvj54l	6	2	comprises	comprise	VBZ
cord-005941-e4fvj54l	6	3	a	a	DT
cord-005941-e4fvj54l	6	4	unique	unique	JJ
cord-005941-e4fvj54l	6	5	mixture	mixture	NN
cord-005941-e4fvj54l	6	6	of	of	IN
cord-005941-e4fvj54l	6	7	phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	6	8	and	and	CC
cord-005941-e4fvj54l	6	9	surfactant	surfactant	NN
cord-005941-e4fvj54l	6	10	-	-	HYPH
cord-005941-e4fvj54l	6	11	specific	specific	JJ
cord-005941-e4fvj54l	6	12	proteins	protein	NNS
cord-005941-e4fvj54l	6	13	.	.	.
cord-005941-e4fvj54l	7	1	More	More	JJR
cord-005941-e4fvj54l	7	2	than	than	IN
cord-005941-e4fvj54l	7	3	30	30	CD
cord-005941-e4fvj54l	7	4	years	year	NNS
cord-005941-e4fvj54l	7	5	after	after	IN
cord-005941-e4fvj54l	7	6	its	-PRON-	PRP$
cord-005941-e4fvj54l	7	7	first	first	JJ
cord-005941-e4fvj54l	7	8	biochemical	biochemical	JJ
cord-005941-e4fvj54l	7	9	characterization	characterization	NN
cord-005941-e4fvj54l	7	10	,	,	,
cord-005941-e4fvj54l	7	11	knowledge	knowledge	NN
cord-005941-e4fvj54l	7	12	of	of	IN
cord-005941-e4fvj54l	7	13	the	the	DT
cord-005941-e4fvj54l	7	14	composition	composition	NN
cord-005941-e4fvj54l	7	15	and	and	CC
cord-005941-e4fvj54l	7	16	functions	function	NNS
cord-005941-e4fvj54l	7	17	of	of	IN
cord-005941-e4fvj54l	7	18	the	the	DT
cord-005941-e4fvj54l	7	19	surfactant	surfactant	NN
cord-005941-e4fvj54l	7	20	complex	complex	NN
cord-005941-e4fvj54l	7	21	has	have	VBZ
cord-005941-e4fvj54l	7	22	grown	grow	VBN
cord-005941-e4fvj54l	7	23	considerably	considerably	RB
cord-005941-e4fvj54l	7	24	.	.	.
cord-005941-e4fvj54l	8	1	Its	-PRON-	PRP$
cord-005941-e4fvj54l	8	2	classically	classically	RB
cord-005941-e4fvj54l	8	3	known	know	VBN
cord-005941-e4fvj54l	8	4	role	role	NN
cord-005941-e4fvj54l	8	5	is	be	VBZ
cord-005941-e4fvj54l	8	6	to	to	TO
cord-005941-e4fvj54l	8	7	decrease	decrease	VB
cord-005941-e4fvj54l	8	8	surface	surface	NN
cord-005941-e4fvj54l	8	9	tension	tension	NN
cord-005941-e4fvj54l	8	10	in	in	IN
cord-005941-e4fvj54l	8	11	alveolar	alveolar	JJ
cord-005941-e4fvj54l	8	12	air	air	NN
cord-005941-e4fvj54l	8	13	spaces	space	NNS
cord-005941-e4fvj54l	8	14	to	to	IN
cord-005941-e4fvj54l	8	15	a	a	DT
cord-005941-e4fvj54l	8	16	degree	degree	NN
cord-005941-e4fvj54l	8	17	that	that	WDT
cord-005941-e4fvj54l	8	18	facilitates	facilitate	VBZ
cord-005941-e4fvj54l	8	19	adequate	adequate	JJ
cord-005941-e4fvj54l	8	20	ventilation	ventilation	NN
cord-005941-e4fvj54l	8	21	of	of	IN
cord-005941-e4fvj54l	8	22	the	the	DT
cord-005941-e4fvj54l	8	23	peripheral	peripheral	JJ
cord-005941-e4fvj54l	8	24	lung	lung	NN
cord-005941-e4fvj54l	8	25	.	.	.
cord-005941-e4fvj54l	9	1	More	more	RBR
cord-005941-e4fvj54l	9	2	recently	recently	RB
cord-005941-e4fvj54l	9	3	,	,	,
cord-005941-e4fvj54l	9	4	other	other	JJ
cord-005941-e4fvj54l	9	5	important	important	JJ
cord-005941-e4fvj54l	9	6	surfactant	surfactant	NN
cord-005941-e4fvj54l	9	7	functions	function	NNS
cord-005941-e4fvj54l	9	8	have	have	VBP
cord-005941-e4fvj54l	9	9	come	come	VBN
cord-005941-e4fvj54l	9	10	into	into	IN
cord-005941-e4fvj54l	9	11	view	view	NN
cord-005941-e4fvj54l	9	12	.	.	.
cord-005941-e4fvj54l	10	1	Probably	probably	RB
cord-005941-e4fvj54l	10	2	most	most	RBS
cord-005941-e4fvj54l	10	3	notable	notable	JJ
cord-005941-e4fvj54l	10	4	among	among	IN
cord-005941-e4fvj54l	10	5	these	these	DT
cord-005941-e4fvj54l	10	6	,	,	,
cord-005941-e4fvj54l	10	7	surfactant	surfactant	NN
cord-005941-e4fvj54l	10	8	has	have	VBZ
cord-005941-e4fvj54l	10	9	been	be	VBN
cord-005941-e4fvj54l	10	10	demonstrated	demonstrate	VBN
cord-005941-e4fvj54l	10	11	to	to	TO
cord-005941-e4fvj54l	10	12	enhance	enhance	VB
cord-005941-e4fvj54l	10	13	local	local	JJ
cord-005941-e4fvj54l	10	14	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	10	15	defense	defense	NN
cord-005941-e4fvj54l	10	16	mechanisms	mechanism	NNS
cord-005941-e4fvj54l	10	17	and	and	CC
cord-005941-e4fvj54l	10	18	to	to	TO
cord-005941-e4fvj54l	10	19	modulate	modulate	VB
cord-005941-e4fvj54l	10	20	immune	immune	JJ
cord-005941-e4fvj54l	10	21	responses	response	NNS
cord-005941-e4fvj54l	10	22	in	in	IN
cord-005941-e4fvj54l	10	23	the	the	DT
cord-005941-e4fvj54l	10	24	alveolar	alveolar	JJ
cord-005941-e4fvj54l	10	25	milieu	milieu	NN
cord-005941-e4fvj54l	10	26	.	.	.
cord-005941-e4fvj54l	11	1	These	these	DT
cord-005941-e4fvj54l	11	2	findings	finding	NNS
cord-005941-e4fvj54l	11	3	have	have	VBP
cord-005941-e4fvj54l	11	4	prompted	prompt	VBN
cord-005941-e4fvj54l	11	5	interest	interest	NN
cord-005941-e4fvj54l	11	6	in	in	IN
cord-005941-e4fvj54l	11	7	the	the	DT
cord-005941-e4fvj54l	11	8	role	role	NN
cord-005941-e4fvj54l	11	9	and	and	CC
cord-005941-e4fvj54l	11	10	the	the	DT
cord-005941-e4fvj54l	11	11	possible	possible	JJ
cord-005941-e4fvj54l	11	12	alterations	alteration	NNS
cord-005941-e4fvj54l	11	13	of	of	IN
cord-005941-e4fvj54l	11	14	the	the	DT
cord-005941-e4fvj54l	11	15	surfactant	surfactant	NN
cord-005941-e4fvj54l	11	16	system	system	NN
cord-005941-e4fvj54l	11	17	in	in	IN
cord-005941-e4fvj54l	11	18	a	a	DT
cord-005941-e4fvj54l	11	19	variety	variety	NN
cord-005941-e4fvj54l	11	20	of	of	IN
cord-005941-e4fvj54l	11	21	lung	lung	NN
cord-005941-e4fvj54l	11	22	diseases	disease	NNS
cord-005941-e4fvj54l	11	23	and	and	CC
cord-005941-e4fvj54l	11	24	in	in	IN
cord-005941-e4fvj54l	11	25	environmental	environmental	JJ
cord-005941-e4fvj54l	11	26	impacts	impact	NNS
cord-005941-e4fvj54l	11	27	on	on	IN
cord-005941-e4fvj54l	11	28	the	the	DT
cord-005941-e4fvj54l	11	29	lung	lung	NN
cord-005941-e4fvj54l	11	30	.	.	.
cord-005941-e4fvj54l	12	1	However	however	RB
cord-005941-e4fvj54l	12	2	,	,	,
cord-005941-e4fvj54l	12	3	only	only	RB
cord-005941-e4fvj54l	12	4	a	a	DT
cord-005941-e4fvj54l	12	5	limited	limited	JJ
cord-005941-e4fvj54l	12	6	number	number	NN
cord-005941-e4fvj54l	12	7	of	of	IN
cord-005941-e4fvj54l	12	8	studies	study	NNS
cord-005941-e4fvj54l	12	9	investigating	investigate	VBG
cord-005941-e4fvj54l	12	10	surfactant	surfactant	NN
cord-005941-e4fvj54l	12	11	changes	change	NNS
cord-005941-e4fvj54l	12	12	in	in	IN
cord-005941-e4fvj54l	12	13	human	human	JJ
cord-005941-e4fvj54l	12	14	lung	lung	NN
cord-005941-e4fvj54l	12	15	disease	disease	NN
cord-005941-e4fvj54l	12	16	have	have	VBP
cord-005941-e4fvj54l	12	17	hitherto	hitherto	VBN
cord-005941-e4fvj54l	12	18	been	be	VBN
cord-005941-e4fvj54l	12	19	published	publish	VBN
cord-005941-e4fvj54l	12	20	.	.	.
cord-005941-e4fvj54l	13	1	Preliminary	preliminary	JJ
cord-005941-e4fvj54l	13	2	results	result	NNS
cord-005941-e4fvj54l	13	3	suggest	suggest	VBP
cord-005941-e4fvj54l	13	4	that	that	IN
cord-005941-e4fvj54l	13	5	surfactant	surfactant	NN
cord-005941-e4fvj54l	13	6	analyses	analysis	NNS
cord-005941-e4fvj54l	13	7	,	,	,
cord-005941-e4fvj54l	13	8	e.g.	e.g.	RB
cord-005941-e4fvj54l	13	9	,	,	,
cord-005941-e4fvj54l	13	10	from	from	IN
cord-005941-e4fvj54l	13	11	bronchoalveolar	bronchoalveolar	NNP
cord-005941-e4fvj54l	13	12	lavage	lavage	NN
cord-005941-e4fvj54l	13	13	fluids	fluid	NNS
cord-005941-e4fvj54l	13	14	,	,	,
cord-005941-e4fvj54l	13	15	may	may	MD
cord-005941-e4fvj54l	13	16	reveal	reveal	VB
cord-005941-e4fvj54l	13	17	quantitative	quantitative	JJ
cord-005941-e4fvj54l	13	18	and	and	CC
cord-005941-e4fvj54l	13	19	qualitative	qualitative	JJ
cord-005941-e4fvj54l	13	20	abnormalities	abnormality	NNS
cord-005941-e4fvj54l	13	21	of	of	IN
cord-005941-e4fvj54l	13	22	the	the	DT
cord-005941-e4fvj54l	13	23	surfactant	surfactant	NN
cord-005941-e4fvj54l	13	24	system	system	NN
cord-005941-e4fvj54l	13	25	in	in	IN
cord-005941-e4fvj54l	13	26	human	human	JJ
cord-005941-e4fvj54l	13	27	lung	lung	NN
cord-005941-e4fvj54l	13	28	disorders	disorder	NNS
cord-005941-e4fvj54l	13	29	.	.	.
cord-005941-e4fvj54l	14	1	It	-PRON-	PRP
cord-005941-e4fvj54l	14	2	is	be	VBZ
cord-005941-e4fvj54l	14	3	hypothesized	hypothesize	VBN
cord-005941-e4fvj54l	14	4	that	that	IN
cord-005941-e4fvj54l	14	5	in	in	IN
cord-005941-e4fvj54l	14	6	the	the	DT
cord-005941-e4fvj54l	14	7	future	future	NN
cord-005941-e4fvj54l	14	8	,	,	,
cord-005941-e4fvj54l	14	9	surfactant	surfactant	NN
cord-005941-e4fvj54l	14	10	studies	study	NNS
cord-005941-e4fvj54l	14	11	may	may	MD
cord-005941-e4fvj54l	14	12	become	become	VB
cord-005941-e4fvj54l	14	13	one	one	CD
cord-005941-e4fvj54l	14	14	of	of	IN
cord-005941-e4fvj54l	14	15	our	-PRON-	PRP$
cord-005941-e4fvj54l	14	16	clinical	clinical	JJ
cord-005941-e4fvj54l	14	17	tools	tool	NNS
cord-005941-e4fvj54l	14	18	to	to	TO
cord-005941-e4fvj54l	14	19	evaluate	evaluate	VB
cord-005941-e4fvj54l	14	20	the	the	DT
cord-005941-e4fvj54l	14	21	activity	activity	NN
cord-005941-e4fvj54l	14	22	and	and	CC
cord-005941-e4fvj54l	14	23	severity	severity	NN
cord-005941-e4fvj54l	14	24	of	of	IN
cord-005941-e4fvj54l	14	25	peripheral	peripheral	JJ
cord-005941-e4fvj54l	14	26	lung	lung	NN
cord-005941-e4fvj54l	14	27	diseases	disease	NNS
cord-005941-e4fvj54l	14	28	.	.	.
cord-005941-e4fvj54l	15	1	In	in	IN
cord-005941-e4fvj54l	15	2	certain	certain	JJ
cord-005941-e4fvj54l	15	3	disorders	disorder	NNS
cord-005941-e4fvj54l	15	4	they	-PRON-	PRP
cord-005941-e4fvj54l	15	5	may	may	MD
cord-005941-e4fvj54l	15	6	also	also	RB
cord-005941-e4fvj54l	15	7	gain	gain	VB
cord-005941-e4fvj54l	15	8	diagnostic	diagnostic	JJ
cord-005941-e4fvj54l	15	9	significance	significance	NN
cord-005941-e4fvj54l	15	10	.	.	.
cord-005941-e4fvj54l	16	1	Further	further	JJ
cord-005941-e4fvj54l	16	2	clinical	clinical	JJ
cord-005941-e4fvj54l	16	3	studies	study	NNS
cord-005941-e4fvj54l	16	4	will	will	MD
cord-005941-e4fvj54l	16	5	be	be	VB
cord-005941-e4fvj54l	16	6	necessary	necessary	JJ
cord-005941-e4fvj54l	16	7	to	to	TO
cord-005941-e4fvj54l	16	8	investigate	investigate	VB
cord-005941-e4fvj54l	16	9	the	the	DT
cord-005941-e4fvj54l	16	10	potential	potential	JJ
cord-005941-e4fvj54l	16	11	therapeutic	therapeutic	JJ
cord-005941-e4fvj54l	16	12	benefits	benefit	NNS
cord-005941-e4fvj54l	16	13	of	of	IN
cord-005941-e4fvj54l	16	14	surfactant	surfactant	NN
cord-005941-e4fvj54l	16	15	substitution	substitution	NN
cord-005941-e4fvj54l	16	16	and	and	CC
cord-005941-e4fvj54l	16	17	the	the	DT
cord-005941-e4fvj54l	16	18	usefulness	usefulness	NN
cord-005941-e4fvj54l	16	19	of	of	IN
cord-005941-e4fvj54l	16	20	pharmacologic	pharmacologic	JJ
cord-005941-e4fvj54l	16	21	manipulation	manipulation	NN
cord-005941-e4fvj54l	16	22	of	of	IN
cord-005941-e4fvj54l	16	23	the	the	DT
cord-005941-e4fvj54l	16	24	secretory	secretory	JJ
cord-005941-e4fvj54l	16	25	activity	activity	NN
cord-005941-e4fvj54l	16	26	of	of	IN
cord-005941-e4fvj54l	16	27	alveolar	alveolar	JJ
cord-005941-e4fvj54l	16	28	type	type	NN
cord-005941-e4fvj54l	16	29	II	ii	CD
cord-005941-e4fvj54l	16	30	cells	cell	NNS
cord-005941-e4fvj54l	16	31	in	in	IN
cord-005941-e4fvj54l	16	32	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	16	33	medicine	medicine	NN
cord-005941-e4fvj54l	16	34	.	.	.
cord-005941-e4fvj54l	17	1	Summary	summary	NN
cord-005941-e4fvj54l	17	2	.	.	.
cord-005941-e4fvj54l	18	1	Pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	18	2	surfactant	surfactant	NN
cord-005941-e4fvj54l	18	3	is	be	VBZ
cord-005941-e4fvj54l	18	4	synthesized	synthesize	VBN
cord-005941-e4fvj54l	18	5	and	and	CC
cord-005941-e4fvj54l	18	6	secreted	secrete	VBN
cord-005941-e4fvj54l	18	7	by	by	IN
cord-005941-e4fvj54l	18	8	alveolar	alveolar	JJ
cord-005941-e4fvj54l	18	9	type	type	NN
cord-005941-e4fvj54l	18	10	II	ii	CD
cord-005941-e4fvj54l	18	11	cells	cell	NNS
cord-005941-e4fvj54l	18	12	and	and	CC
cord-005941-e4fvj54l	18	13	constitutes	constitute	VBZ
cord-005941-e4fvj54l	18	14	an	an	DT
cord-005941-e4fvj54l	18	15	important	important	JJ
cord-005941-e4fvj54l	18	16	component	component	NN
cord-005941-e4fvj54l	18	17	of	of	IN
cord-005941-e4fvj54l	18	18	the	the	DT
cord-005941-e4fvj54l	18	19	alveolar	alveolar	NN
cord-005941-e4fvj54l	18	20	lining	lining	NN
cord-005941-e4fvj54l	18	21	fluid	fluid	NN
cord-005941-e4fvj54l	18	22	.	.	.
cord-005941-e4fvj54l	19	1	It	-PRON-	PRP
cord-005941-e4fvj54l	19	2	comprises	comprise	VBZ
cord-005941-e4fvj54l	19	3	a	a	DT
cord-005941-e4fvj54l	19	4	unique	unique	JJ
cord-005941-e4fvj54l	19	5	mixture	mixture	NN
cord-005941-e4fvj54l	19	6	of	of	IN
cord-005941-e4fvj54l	19	7	phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	19	8	and	and	CC
cord-005941-e4fvj54l	19	9	surfactant	surfactant	NN
cord-005941-e4fvj54l	19	10	-	-	HYPH
cord-005941-e4fvj54l	19	11	specific	specific	JJ
cord-005941-e4fvj54l	19	12	proteins	protein	NNS
cord-005941-e4fvj54l	19	13	.	.	.
cord-005941-e4fvj54l	20	1	More	More	JJR
cord-005941-e4fvj54l	20	2	than	than	IN
cord-005941-e4fvj54l	20	3	30	30	CD
cord-005941-e4fvj54l	20	4	years	year	NNS
cord-005941-e4fvj54l	20	5	after	after	IN
cord-005941-e4fvj54l	20	6	its	-PRON-	PRP$
cord-005941-e4fvj54l	20	7	first	first	JJ
cord-005941-e4fvj54l	20	8	biochemical	biochemical	JJ
cord-005941-e4fvj54l	20	9	characterization	characterization	NN
cord-005941-e4fvj54l	20	10	,	,	,
cord-005941-e4fvj54l	20	11	knowledge	knowledge	NN
cord-005941-e4fvj54l	20	12	of	of	IN
cord-005941-e4fvj54l	20	13	the	the	DT
cord-005941-e4fvj54l	20	14	composition	composition	NN
cord-005941-e4fvj54l	20	15	and	and	CC
cord-005941-e4fvj54l	20	16	functions	function	NNS
cord-005941-e4fvj54l	20	17	of	of	IN
cord-005941-e4fvj54l	20	18	the	the	DT
cord-005941-e4fvj54l	20	19	surfactant	surfactant	NN
cord-005941-e4fvj54l	20	20	complex	complex	NN
cord-005941-e4fvj54l	20	21	has	have	VBZ
cord-005941-e4fvj54l	20	22	grown	grow	VBN
cord-005941-e4fvj54l	20	23	considerably	considerably	RB
cord-005941-e4fvj54l	20	24	.	.	.
cord-005941-e4fvj54l	21	1	Its	-PRON-	PRP$
cord-005941-e4fvj54l	21	2	classically	classically	RB
cord-005941-e4fvj54l	21	3	known	know	VBN
cord-005941-e4fvj54l	21	4	role	role	NN
cord-005941-e4fvj54l	21	5	is	be	VBZ
cord-005941-e4fvj54l	21	6	to	to	TO
cord-005941-e4fvj54l	21	7	decrease	decrease	VB
cord-005941-e4fvj54l	21	8	surface	surface	NN
cord-005941-e4fvj54l	21	9	tension	tension	NN
cord-005941-e4fvj54l	21	10	in	in	IN
cord-005941-e4fvj54l	21	11	alveolar	alveolar	JJ
cord-005941-e4fvj54l	21	12	air	air	NN
cord-005941-e4fvj54l	21	13	spaces	space	NNS
cord-005941-e4fvj54l	21	14	to	to	IN
cord-005941-e4fvj54l	21	15	a	a	DT
cord-005941-e4fvj54l	21	16	degree	degree	NN
cord-005941-e4fvj54l	21	17	that	that	WDT
cord-005941-e4fvj54l	21	18	facilitates	facilitate	VBZ
cord-005941-e4fvj54l	21	19	adequate	adequate	JJ
cord-005941-e4fvj54l	21	20	ventilation	ventilation	NN
cord-005941-e4fvj54l	21	21	of	of	IN
cord-005941-e4fvj54l	21	22	the	the	DT
cord-005941-e4fvj54l	21	23	peripheral	peripheral	JJ
cord-005941-e4fvj54l	21	24	lung	lung	NN
cord-005941-e4fvj54l	21	25	.	.	.
cord-005941-e4fvj54l	22	1	More	more	RBR
cord-005941-e4fvj54l	22	2	recently	recently	RB
cord-005941-e4fvj54l	22	3	,	,	,
cord-005941-e4fvj54l	22	4	other	other	JJ
cord-005941-e4fvj54l	22	5	important	important	JJ
cord-005941-e4fvj54l	22	6	surfactant	surfactant	NN
cord-005941-e4fvj54l	22	7	functions	function	NNS
cord-005941-e4fvj54l	22	8	have	have	VBP
cord-005941-e4fvj54l	22	9	come	come	VBN
cord-005941-e4fvj54l	22	10	into	into	IN
cord-005941-e4fvj54l	22	11	view	view	NN
cord-005941-e4fvj54l	22	12	.	.	.
cord-005941-e4fvj54l	23	1	Probably	probably	RB
cord-005941-e4fvj54l	23	2	most	most	RBS
cord-005941-e4fvj54l	23	3	notable	notable	JJ
cord-005941-e4fvj54l	23	4	among	among	IN
cord-005941-e4fvj54l	23	5	these	these	DT
cord-005941-e4fvj54l	23	6	,	,	,
cord-005941-e4fvj54l	23	7	surfactant	surfactant	NN
cord-005941-e4fvj54l	23	8	has	have	VBZ
cord-005941-e4fvj54l	23	9	been	be	VBN
cord-005941-e4fvj54l	23	10	demonstrated	demonstrate	VBN
cord-005941-e4fvj54l	23	11	to	to	TO
cord-005941-e4fvj54l	23	12	enhance	enhance	VB
cord-005941-e4fvj54l	23	13	local	local	JJ
cord-005941-e4fvj54l	23	14	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	23	15	defense	defense	NN
cord-005941-e4fvj54l	23	16	mechanisms	mechanism	NNS
cord-005941-e4fvj54l	23	17	and	and	CC
cord-005941-e4fvj54l	23	18	to	to	TO
cord-005941-e4fvj54l	23	19	modulate	modulate	VB
cord-005941-e4fvj54l	23	20	immune	immune	JJ
cord-005941-e4fvj54l	23	21	responses	response	NNS
cord-005941-e4fvj54l	23	22	in	in	IN
cord-005941-e4fvj54l	23	23	the	the	DT
cord-005941-e4fvj54l	23	24	alveolar	alveolar	JJ
cord-005941-e4fvj54l	23	25	milieu	milieu	NN
cord-005941-e4fvj54l	23	26	.	.	.
cord-005941-e4fvj54l	24	1	These	these	DT
cord-005941-e4fvj54l	24	2	findings	finding	NNS
cord-005941-e4fvj54l	24	3	have	have	VBP
cord-005941-e4fvj54l	24	4	prompted	prompt	VBN
cord-005941-e4fvj54l	24	5	interest	interest	NN
cord-005941-e4fvj54l	24	6	in	in	IN
cord-005941-e4fvj54l	24	7	the	the	DT
cord-005941-e4fvj54l	24	8	role	role	NN
cord-005941-e4fvj54l	24	9	and	and	CC
cord-005941-e4fvj54l	24	10	the	the	DT
cord-005941-e4fvj54l	24	11	possible	possible	JJ
cord-005941-e4fvj54l	24	12	alterations	alteration	NNS
cord-005941-e4fvj54l	24	13	of	of	IN
cord-005941-e4fvj54l	24	14	the	the	DT
cord-005941-e4fvj54l	24	15	surfactant	surfactant	NN
cord-005941-e4fvj54l	24	16	system	system	NN
cord-005941-e4fvj54l	24	17	in	in	IN
cord-005941-e4fvj54l	24	18	a	a	DT
cord-005941-e4fvj54l	24	19	variety	variety	NN
cord-005941-e4fvj54l	24	20	of	of	IN
cord-005941-e4fvj54l	24	21	lung	lung	NN
cord-005941-e4fvj54l	24	22	diseases	disease	NNS
cord-005941-e4fvj54l	24	23	and	and	CC
cord-005941-e4fvj54l	24	24	in	in	IN
cord-005941-e4fvj54l	24	25	environmental	environmental	JJ
cord-005941-e4fvj54l	24	26	impacts	impact	NNS
cord-005941-e4fvj54l	24	27	on	on	IN
cord-005941-e4fvj54l	24	28	the	the	DT
cord-005941-e4fvj54l	24	29	lung	lung	NN
cord-005941-e4fvj54l	24	30	.	.	.
cord-005941-e4fvj54l	25	1	However	however	RB
cord-005941-e4fvj54l	25	2	,	,	,
cord-005941-e4fvj54l	25	3	only	only	RB
cord-005941-e4fvj54l	25	4	a	a	DT
cord-005941-e4fvj54l	25	5	limited	limited	JJ
cord-005941-e4fvj54l	25	6	number	number	NN
cord-005941-e4fvj54l	25	7	of	of	IN
cord-005941-e4fvj54l	25	8	studies	study	NNS
cord-005941-e4fvj54l	25	9	investigating	investigate	VBG
cord-005941-e4fvj54l	25	10	surfactant	surfactant	NN
cord-005941-e4fvj54l	25	11	changes	change	NNS
cord-005941-e4fvj54l	25	12	in	in	IN
cord-005941-e4fvj54l	25	13	human	human	JJ
cord-005941-e4fvj54l	25	14	lung	lung	NN
cord-005941-e4fvj54l	25	15	disease	disease	NN
cord-005941-e4fvj54l	25	16	have	have	VBP
cord-005941-e4fvj54l	25	17	hitherto	hitherto	VBN
cord-005941-e4fvj54l	25	18	been	be	VBN
cord-005941-e4fvj54l	25	19	published	publish	VBN
cord-005941-e4fvj54l	25	20	.	.	.
cord-005941-e4fvj54l	26	1	Preliminary	preliminary	JJ
cord-005941-e4fvj54l	26	2	results	result	NNS
cord-005941-e4fvj54l	26	3	suggest	suggest	VBP
cord-005941-e4fvj54l	26	4	that	that	IN
cord-005941-e4fvj54l	26	5	surfactant	surfactant	NN
cord-005941-e4fvj54l	26	6	analyses	analysis	NNS
cord-005941-e4fvj54l	26	7	,	,	,
cord-005941-e4fvj54l	26	8	e.g.	e.g.	RB
cord-005941-e4fvj54l	26	9	,	,	,
cord-005941-e4fvj54l	26	10	from	from	IN
cord-005941-e4fvj54l	26	11	bronchoalveolar	bronchoalveolar	NNP
cord-005941-e4fvj54l	26	12	lavage	lavage	NN
cord-005941-e4fvj54l	26	13	fluids	fluid	NNS
cord-005941-e4fvj54l	26	14	,	,	,
cord-005941-e4fvj54l	26	15	may	may	MD
cord-005941-e4fvj54l	26	16	reveal	reveal	VB
cord-005941-e4fvj54l	26	17	quantitative	quantitative	JJ
cord-005941-e4fvj54l	26	18	and	and	CC
cord-005941-e4fvj54l	26	19	qualitative	qualitative	JJ
cord-005941-e4fvj54l	26	20	abnormalities	abnormality	NNS
cord-005941-e4fvj54l	26	21	of	of	IN
cord-005941-e4fvj54l	26	22	the	the	DT
cord-005941-e4fvj54l	26	23	surfactant	surfactant	NN
cord-005941-e4fvj54l	26	24	system	system	NN
cord-005941-e4fvj54l	26	25	in	in	IN
cord-005941-e4fvj54l	26	26	human	human	JJ
cord-005941-e4fvj54l	26	27	lung	lung	NN
cord-005941-e4fvj54l	26	28	disorders	disorder	NNS
cord-005941-e4fvj54l	26	29	.	.	.
cord-005941-e4fvj54l	27	1	It	-PRON-	PRP
cord-005941-e4fvj54l	27	2	is	be	VBZ
cord-005941-e4fvj54l	27	3	hypothesized	hypothesize	VBN
cord-005941-e4fvj54l	27	4	that	that	IN
cord-005941-e4fvj54l	27	5	in	in	IN
cord-005941-e4fvj54l	27	6	the	the	DT
cord-005941-e4fvj54l	27	7	future	future	NN
cord-005941-e4fvj54l	27	8	,	,	,
cord-005941-e4fvj54l	27	9	surfactant	surfactant	NN
cord-005941-e4fvj54l	27	10	studies	study	NNS
cord-005941-e4fvj54l	27	11	may	may	MD
cord-005941-e4fvj54l	27	12	become	become	VB
cord-005941-e4fvj54l	27	13	one	one	CD
cord-005941-e4fvj54l	27	14	of	of	IN
cord-005941-e4fvj54l	27	15	our	-PRON-	PRP$
cord-005941-e4fvj54l	27	16	clinical	clinical	JJ
cord-005941-e4fvj54l	27	17	tools	tool	NNS
cord-005941-e4fvj54l	27	18	to	to	TO
cord-005941-e4fvj54l	27	19	evaluate	evaluate	VB
cord-005941-e4fvj54l	27	20	the	the	DT
cord-005941-e4fvj54l	27	21	activity	activity	NN
cord-005941-e4fvj54l	27	22	and	and	CC
cord-005941-e4fvj54l	27	23	severity	severity	NN
cord-005941-e4fvj54l	27	24	of	of	IN
cord-005941-e4fvj54l	27	25	peripheral	peripheral	JJ
cord-005941-e4fvj54l	27	26	lung	lung	NN
cord-005941-e4fvj54l	27	27	diseases	disease	NNS
cord-005941-e4fvj54l	27	28	.	.	.
cord-005941-e4fvj54l	28	1	In	in	IN
cord-005941-e4fvj54l	28	2	certain	certain	JJ
cord-005941-e4fvj54l	28	3	disorders	disorder	NNS
cord-005941-e4fvj54l	28	4	they	-PRON-	PRP
cord-005941-e4fvj54l	28	5	may	may	MD
cord-005941-e4fvj54l	28	6	also	also	RB
cord-005941-e4fvj54l	28	7	gain	gain	VB
cord-005941-e4fvj54l	28	8	diagnostic	diagnostic	JJ
cord-005941-e4fvj54l	28	9	significance	significance	NN
cord-005941-e4fvj54l	28	10	.	.	.
cord-005941-e4fvj54l	29	1	Further	further	JJ
cord-005941-e4fvj54l	29	2	clinical	clinical	JJ
cord-005941-e4fvj54l	29	3	studies	study	NNS
cord-005941-e4fvj54l	29	4	will	will	MD
cord-005941-e4fvj54l	29	5	be	be	VB
cord-005941-e4fvj54l	29	6	necessary	necessary	JJ
cord-005941-e4fvj54l	29	7	to	to	TO
cord-005941-e4fvj54l	29	8	investigate	investigate	VB
cord-005941-e4fvj54l	29	9	the	the	DT
cord-005941-e4fvj54l	29	10	potential	potential	JJ
cord-005941-e4fvj54l	29	11	therapeutic	therapeutic	JJ
cord-005941-e4fvj54l	29	12	benefits	benefit	NNS
cord-005941-e4fvj54l	29	13	of	of	IN
cord-005941-e4fvj54l	29	14	surfactant	surfactant	NN
cord-005941-e4fvj54l	29	15	substitution	substitution	NN
cord-005941-e4fvj54l	29	16	and	and	CC
cord-005941-e4fvj54l	29	17	the	the	DT
cord-005941-e4fvj54l	29	18	usefulness	usefulness	NN
cord-005941-e4fvj54l	29	19	of	of	IN
cord-005941-e4fvj54l	29	20	pharmacologic	pharmacologic	JJ
cord-005941-e4fvj54l	29	21	manipulation	manipulation	NN
cord-005941-e4fvj54l	29	22	of	of	IN
cord-005941-e4fvj54l	29	23	Surfactant	Surfactant	NNP
cord-005941-e4fvj54l	29	24	(	(	-LRB-
cord-005941-e4fvj54l	29	25	=	=	SYM
cord-005941-e4fvj54l	29	26	surface	surface	NN
cord-005941-e4fvj54l	29	27	active	active	JJ
cord-005941-e4fvj54l	29	28	agent	agent	NN
cord-005941-e4fvj54l	29	29	)	)	-RRB-
cord-005941-e4fvj54l	29	30	is	be	VBZ
cord-005941-e4fvj54l	29	31	a	a	DT
cord-005941-e4fvj54l	29	32	material	material	NN
cord-005941-e4fvj54l	29	33	capable	capable	JJ
cord-005941-e4fvj54l	29	34	of	of	IN
cord-005941-e4fvj54l	29	35	lowering	lower	VBG
cord-005941-e4fvj54l	29	36	surface	surface	NN
cord-005941-e4fvj54l	29	37	tension	tension	NN
cord-005941-e4fvj54l	29	38	.	.	.
cord-005941-e4fvj54l	30	1	The	the	DT
cord-005941-e4fvj54l	30	2	existence	existence	NN
cord-005941-e4fvj54l	30	3	of	of	IN
cord-005941-e4fvj54l	30	4	a	a	DT
cord-005941-e4fvj54l	30	5	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	30	6	surface	surface	NN
cord-005941-e4fvj54l	30	7	active	active	JJ
cord-005941-e4fvj54l	30	8	substance	substance	NN
cord-005941-e4fvj54l	30	9	was	be	VBD
cord-005941-e4fvj54l	30	10	first	first	RB
cord-005941-e4fvj54l	30	11	postulated	postulate	VBN
cord-005941-e4fvj54l	30	12	by	by	IN
cord-005941-e4fvj54l	30	13	Van	Van	NNP
cord-005941-e4fvj54l	30	14	Neergard	Neergard	NNP
cord-005941-e4fvj54l	30	15	in	in	IN
cord-005941-e4fvj54l	30	16	1929	1929	CD
cord-005941-e4fvj54l	30	17	[	[	-LRB-
cord-005941-e4fvj54l	30	18	181	181	CD
cord-005941-e4fvj54l	30	19	]	]	-RRB-
cord-005941-e4fvj54l	30	20	.	.	.
cord-005941-e4fvj54l	31	1	He	-PRON-	PRP
cord-005941-e4fvj54l	31	2	found	find	VBD
cord-005941-e4fvj54l	31	3	the	the	DT
cord-005941-e4fvj54l	31	4	calculated	calculate	VBN
cord-005941-e4fvj54l	31	5	surface	surface	NN
cord-005941-e4fvj54l	31	6	tension	tension	NN
cord-005941-e4fvj54l	31	7	of	of	IN
cord-005941-e4fvj54l	31	8	the	the	DT
cord-005941-e4fvj54l	31	9	alveolar	alveolar	JJ
cord-005941-e4fvj54l	31	10	air	air	NN
cord-005941-e4fvj54l	31	11	-	-	HYPH
cord-005941-e4fvj54l	31	12	liquid	liquid	NN
cord-005941-e4fvj54l	31	13	interface	interface	NN
cord-005941-e4fvj54l	31	14	to	to	TO
cord-005941-e4fvj54l	31	15	be	be	VB
cord-005941-e4fvj54l	31	16	too	too	RB
cord-005941-e4fvj54l	31	17	high	high	JJ
cord-005941-e4fvj54l	31	18	to	to	TO
cord-005941-e4fvj54l	31	19	prevent	prevent	VB
cord-005941-e4fvj54l	31	20	endexpiratory	endexpiratory	NN
cord-005941-e4fvj54l	31	21	alveolar	alveolar	JJ
cord-005941-e4fvj54l	31	22	collapse	collapse	NN
cord-005941-e4fvj54l	31	23	and	and	CC
cord-005941-e4fvj54l	31	24	atelectasis	atelectasis	NN
cord-005941-e4fvj54l	31	25	.	.	.
cord-005941-e4fvj54l	32	1	Therefore	therefore	RB
cord-005941-e4fvj54l	32	2	,	,	,
cord-005941-e4fvj54l	32	3	he	-PRON-	PRP
cord-005941-e4fvj54l	32	4	predicted	predict	VBD
cord-005941-e4fvj54l	32	5	the	the	DT
cord-005941-e4fvj54l	32	6	presence	presence	NN
cord-005941-e4fvj54l	32	7	of	of	IN
cord-005941-e4fvj54l	32	8	an	an	DT
cord-005941-e4fvj54l	32	9	agent	agent	NN
cord-005941-e4fvj54l	32	10	able	able	JJ
cord-005941-e4fvj54l	32	11	to	to	TO
cord-005941-e4fvj54l	32	12	exert	exert	VB
cord-005941-e4fvj54l	32	13	and	and	CC
cord-005941-e4fvj54l	32	14	maintain	maintain	VB
cord-005941-e4fvj54l	32	15	a	a	DT
cord-005941-e4fvj54l	32	16	low	low	JJ
cord-005941-e4fvj54l	32	17	alveolar	alveolar	NN
cord-005941-e4fvj54l	32	18	surface	surface	NN
cord-005941-e4fvj54l	32	19	tension	tension	NN
cord-005941-e4fvj54l	32	20	as	as	IN
cord-005941-e4fvj54l	32	21	a	a	DT
cord-005941-e4fvj54l	32	22	prerequisite	prerequisite	NN
cord-005941-e4fvj54l	32	23	for	for	IN
cord-005941-e4fvj54l	32	24	the	the	DT
cord-005941-e4fvj54l	32	25	adequate	adequate	JJ
cord-005941-e4fvj54l	32	26	ventilation	ventilation	NN
cord-005941-e4fvj54l	32	27	of	of	IN
cord-005941-e4fvj54l	32	28	the	the	DT
cord-005941-e4fvj54l	32	29	peripheral	peripheral	JJ
cord-005941-e4fvj54l	32	30	airways	airway	NNS
cord-005941-e4fvj54l	32	31	and	and	CC
cord-005941-e4fvj54l	32	32	for	for	IN
cord-005941-e4fvj54l	32	33	normal	normal	JJ
cord-005941-e4fvj54l	32	34	lung	lung	NN
cord-005941-e4fvj54l	32	35	function	function	NN
cord-005941-e4fvj54l	32	36	.	.	.
cord-005941-e4fvj54l	33	1	It	-PRON-	PRP
cord-005941-e4fvj54l	33	2	was	be	VBD
cord-005941-e4fvj54l	33	3	almost	almost	RB
cord-005941-e4fvj54l	33	4	another	another	DT
cord-005941-e4fvj54l	33	5	30	30	CD
cord-005941-e4fvj54l	33	6	years	year	NNS
cord-005941-e4fvj54l	33	7	until	until	IN
cord-005941-e4fvj54l	33	8	Pattle	pattle	NN
cord-005941-e4fvj54l	33	9	[	[	-LRB-
cord-005941-e4fvj54l	33	10	135	135	CD
cord-005941-e4fvj54l	33	11	]	]	-RRB-
cord-005941-e4fvj54l	33	12	and	and	CC
cord-005941-e4fvj54l	33	13	Clements	Clements	NNP
cord-005941-e4fvj54l	33	14	[	[	-LRB-
cord-005941-e4fvj54l	33	15	20	20	CD
cord-005941-e4fvj54l	33	16	]	]	-RRB-
cord-005941-e4fvj54l	33	17	found	find	VBD
cord-005941-e4fvj54l	33	18	a	a	DT
cord-005941-e4fvj54l	33	19	substance	substance	NN
cord-005941-e4fvj54l	33	20	in	in	IN
cord-005941-e4fvj54l	33	21	lung	lung	NN
cord-005941-e4fvj54l	33	22	edema	edema	NN
cord-005941-e4fvj54l	33	23	fluid	fluid	NN
cord-005941-e4fvj54l	33	24	and	and	CC
cord-005941-e4fvj54l	33	25	in	in	IN
cord-005941-e4fvj54l	33	26	lung	lung	NN
cord-005941-e4fvj54l	33	27	extracts	extract	NNS
cord-005941-e4fvj54l	33	28	that	that	WDT
cord-005941-e4fvj54l	33	29	indeed	indeed	RB
cord-005941-e4fvj54l	33	30	lowered	lower	VBD
cord-005941-e4fvj54l	33	31	the	the	DT
cord-005941-e4fvj54l	33	32	surface	surface	NN
cord-005941-e4fvj54l	33	33	tension	tension	NN
cord-005941-e4fvj54l	33	34	dramatically	dramatically	RB
cord-005941-e4fvj54l	33	35	.	.	.
cord-005941-e4fvj54l	34	1	The	the	DT
cord-005941-e4fvj54l	34	2	material	material	NN
cord-005941-e4fvj54l	34	3	was	be	VBD
cord-005941-e4fvj54l	34	4	found	find	VBN
cord-005941-e4fvj54l	34	5	to	to	TO
cord-005941-e4fvj54l	34	6	be	be	VB
cord-005941-e4fvj54l	34	7	composed	compose	VBN
cord-005941-e4fvj54l	34	8	of	of	IN
cord-005941-e4fvj54l	34	9	a	a	DT
cord-005941-e4fvj54l	34	10	phospholipid	phospholipid	NN
cord-005941-e4fvj54l	34	11	and	and	CC
cord-005941-e4fvj54l	34	12	a	a	DT
cord-005941-e4fvj54l	34	13	protein	protein	NN
cord-005941-e4fvj54l	34	14	fraction	fraction	NN
cord-005941-e4fvj54l	34	15	.	.	.
cord-005941-e4fvj54l	35	1	In	in	IN
cord-005941-e4fvj54l	35	2	1959	1959	CD
cord-005941-e4fvj54l	35	3	,	,	,
cord-005941-e4fvj54l	35	4	Avery	Avery	NNP
cord-005941-e4fvj54l	35	5	and	and	CC
cord-005941-e4fvj54l	35	6	Mead	Mead	NNP
cord-005941-e4fvj54l	35	7	[	[	-LRB-
cord-005941-e4fvj54l	35	8	4	4	CD
cord-005941-e4fvj54l	35	9	]	]	-RRB-
cord-005941-e4fvj54l	35	10	drew	draw	VBD
cord-005941-e4fvj54l	35	11	attention	attention	NN
cord-005941-e4fvj54l	35	12	to	to	IN
cord-005941-e4fvj54l	35	13	the	the	DT
cord-005941-e4fvj54l	35	14	role	role	NN
cord-005941-e4fvj54l	35	15	of	of	IN
cord-005941-e4fvj54l	35	16	a	a	DT
cord-005941-e4fvj54l	35	17	surfactant	surfactant	NN
cord-005941-e4fvj54l	35	18	deficit	deficit	NN
cord-005941-e4fvj54l	35	19	in	in	IN
cord-005941-e4fvj54l	35	20	hyaline	hyaline	JJ
cord-005941-e4fvj54l	35	21	membrane	membrane	NN
cord-005941-e4fvj54l	35	22	disease	disease	NN
cord-005941-e4fvj54l	35	23	(	(	-LRB-
cord-005941-e4fvj54l	35	24	IRDS	IRDS	NNP
cord-005941-e4fvj54l	35	25	)	)	-RRB-
cord-005941-e4fvj54l	35	26	of	of	IN
cord-005941-e4fvj54l	35	27	premature	premature	JJ
cord-005941-e4fvj54l	35	28	infants	infant	NNS
cord-005941-e4fvj54l	35	29	.	.	.
cord-005941-e4fvj54l	36	1	Thus	thus	RB
cord-005941-e4fvj54l	36	2	,	,	,
cord-005941-e4fvj54l	36	3	clinical	clinical	JJ
cord-005941-e4fvj54l	36	4	relevance	relevance	NN
cord-005941-e4fvj54l	36	5	and	and	CC
cord-005941-e4fvj54l	36	6	a	a	DT
cord-005941-e4fvj54l	36	7	first	first	JJ
cord-005941-e4fvj54l	36	8	therapeutic	therapeutic	JJ
cord-005941-e4fvj54l	36	9	perspective	perspective	NN
cord-005941-e4fvj54l	36	10	became	become	VBD
cord-005941-e4fvj54l	36	11	apparent	apparent	JJ
cord-005941-e4fvj54l	36	12	in	in	IN
cord-005941-e4fvj54l	36	13	surfactant	surfactant	NN
cord-005941-e4fvj54l	36	14	research	research	NN
cord-005941-e4fvj54l	36	15	.	.	.
cord-005941-e4fvj54l	37	1	More	More	JJR
cord-005941-e4fvj54l	37	2	than	than	IN
cord-005941-e4fvj54l	37	3	another	another	DT
cord-005941-e4fvj54l	37	4	30	30	CD
cord-005941-e4fvj54l	37	5	years	year	NNS
cord-005941-e4fvj54l	37	6	later	later	RB
cord-005941-e4fvj54l	37	7	,	,	,
cord-005941-e4fvj54l	37	8	the	the	DT
cord-005941-e4fvj54l	37	9	understanding	understanding	NN
cord-005941-e4fvj54l	37	10	of	of	IN
cord-005941-e4fvj54l	37	11	the	the	DT
cord-005941-e4fvj54l	37	12	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	37	13	surfactant	surfactant	NN
cord-005941-e4fvj54l	37	14	system	system	NN
cord-005941-e4fvj54l	37	15	has	have	VBZ
cord-005941-e4fvj54l	37	16	grown	grow	VBN
cord-005941-e4fvj54l	37	17	tremendously	tremendously	RB
cord-005941-e4fvj54l	37	18	.	.	.
cord-005941-e4fvj54l	38	1	The	the	DT
cord-005941-e4fvj54l	38	2	precise	precise	JJ
cord-005941-e4fvj54l	38	3	composition	composition	NN
cord-005941-e4fvj54l	38	4	of	of	IN
cord-005941-e4fvj54l	38	5	the	the	DT
cord-005941-e4fvj54l	38	6	surfactant	surfactant	NN
cord-005941-e4fvj54l	38	7	is	be	VBZ
cord-005941-e4fvj54l	38	8	known	know	VBN
cord-005941-e4fvj54l	38	9	down	down	RP
cord-005941-e4fvj54l	38	10	to	to	IN
cord-005941-e4fvj54l	38	11	the	the	DT
cord-005941-e4fvj54l	38	12	genetic	genetic	JJ
cord-005941-e4fvj54l	38	13	codes	code	NNS
cord-005941-e4fvj54l	38	14	of	of	IN
cord-005941-e4fvj54l	38	15	surfactent	surfactent	NN
cord-005941-e4fvj54l	38	16	-	-	HYPH
cord-005941-e4fvj54l	38	17	specific	specific	JJ
cord-005941-e4fvj54l	38	18	proteins	protein	NNS
cord-005941-e4fvj54l	38	19	,	,	,
cord-005941-e4fvj54l	38	20	making	make	VBG
cord-005941-e4fvj54l	38	21	the	the	DT
cord-005941-e4fvj54l	38	22	industrial	industrial	JJ
cord-005941-e4fvj54l	38	23	production	production	NN
cord-005941-e4fvj54l	38	24	of	of	IN
cord-005941-e4fvj54l	38	25	different	different	JJ
cord-005941-e4fvj54l	38	26	surfactants	surfactant	NNS
cord-005941-e4fvj54l	38	27	a	a	DT
cord-005941-e4fvj54l	38	28	realistic	realistic	JJ
cord-005941-e4fvj54l	38	29	prospect	prospect	NN
cord-005941-e4fvj54l	38	30	.	.	.
cord-005941-e4fvj54l	39	1	Much	much	JJ
cord-005941-e4fvj54l	39	2	has	have	VBZ
cord-005941-e4fvj54l	39	3	been	be	VBN
cord-005941-e4fvj54l	39	4	learnt	learn	VBN
cord-005941-e4fvj54l	39	5	about	about	IN
cord-005941-e4fvj54l	39	6	surfactant	surfactant	NN
cord-005941-e4fvj54l	39	7	synthesis	synthesis	NN
cord-005941-e4fvj54l	39	8	in	in	IN
cord-005941-e4fvj54l	39	9	the	the	DT
cord-005941-e4fvj54l	39	10	alveolar	alveolar	JJ
cord-005941-e4fvj54l	39	11	type	type	NN
cord-005941-e4fvj54l	39	12	II	ii	CD
cord-005941-e4fvj54l	39	13	cell	cell	NN
cord-005941-e4fvj54l	39	14	and	and	CC
cord-005941-e4fvj54l	39	15	its	-PRON-	PRP$
cord-005941-e4fvj54l	39	16	regulation	regulation	NN
cord-005941-e4fvj54l	39	17	and	and	CC
cord-005941-e4fvj54l	39	18	metabolism	metabolism	NN
cord-005941-e4fvj54l	39	19	.	.	.
cord-005941-e4fvj54l	40	1	Intratracheal	intratracheal	NN
cord-005941-e4fvj54l	40	2	surfactant	surfactant	NN
cord-005941-e4fvj54l	40	3	re	re	NN
cord-005941-e4fvj54l	40	4	-	-	NN
cord-005941-e4fvj54l	40	5	placement	placement	NN
cord-005941-e4fvj54l	40	6	is	be	VBZ
cord-005941-e4fvj54l	40	7	on	on	IN
cord-005941-e4fvj54l	40	8	the	the	DT
cord-005941-e4fvj54l	40	9	verge	verge	NN
cord-005941-e4fvj54l	40	10	of	of	IN
cord-005941-e4fvj54l	40	11	becoming	become	VBG
cord-005941-e4fvj54l	40	12	a	a	DT
cord-005941-e4fvj54l	40	13	routine	routine	JJ
cord-005941-e4fvj54l	40	14	life	life	NN
cord-005941-e4fvj54l	40	15	-	-	HYPH
cord-005941-e4fvj54l	40	16	saving	save	VBG
cord-005941-e4fvj54l	40	17	therapy	therapy	NN
cord-005941-e4fvj54l	40	18	in	in	IN
cord-005941-e4fvj54l	40	19	IRDS	IRDS	NNP
cord-005941-e4fvj54l	40	20	.	.	.
cord-005941-e4fvj54l	41	1	Accumulating	accumulate	VBG
cord-005941-e4fvj54l	41	2	evidence	evidence	NN
cord-005941-e4fvj54l	41	3	suggests	suggest	VBZ
cord-005941-e4fvj54l	41	4	that	that	IN
cord-005941-e4fvj54l	41	5	in	in	IN
cord-005941-e4fvj54l	41	6	adult	adult	JJ
cord-005941-e4fvj54l	41	7	respiratory	respiratory	JJ
cord-005941-e4fvj54l	41	8	distress	distress	NN
cord-005941-e4fvj54l	41	9	syndrome	syndrome	NN
cord-005941-e4fvj54l	41	10	(	(	-LRB-
cord-005941-e4fvj54l	41	11	ARDS	ARDS	NNP
cord-005941-e4fvj54l	41	12	)	)	-RRB-
cord-005941-e4fvj54l	41	13	a	a	DT
cord-005941-e4fvj54l	41	14	similar	similar	JJ
cord-005941-e4fvj54l	41	15	disturbance	disturbance	NN
cord-005941-e4fvj54l	41	16	of	of	IN
cord-005941-e4fvj54l	41	17	the	the	DT
cord-005941-e4fvj54l	41	18	surfactant	surfactant	NN
cord-005941-e4fvj54l	41	19	system	system	NN
cord-005941-e4fvj54l	41	20	is	be	VBZ
cord-005941-e4fvj54l	41	21	involved	involve	VBN
cord-005941-e4fvj54l	41	22	which	which	WDT
cord-005941-e4fvj54l	41	23	may	may	MD
cord-005941-e4fvj54l	41	24	possibly	possibly	RB
cord-005941-e4fvj54l	41	25	be	be	VB
cord-005941-e4fvj54l	41	26	ameliorated	ameliorate	VBN
cord-005941-e4fvj54l	41	27	by	by	IN
cord-005941-e4fvj54l	41	28	substitution	substitution	NN
cord-005941-e4fvj54l	41	29	therapy	therapy	NN
cord-005941-e4fvj54l	41	30	.	.	.
cord-005941-e4fvj54l	42	1	In	in	IN
cord-005941-e4fvj54l	42	2	recent	recent	JJ
cord-005941-e4fvj54l	42	3	years	year	NNS
cord-005941-e4fvj54l	42	4	,	,	,
cord-005941-e4fvj54l	42	5	surfactant	surfactant	NN
cord-005941-e4fvj54l	42	6	functions	function	NNS
cord-005941-e4fvj54l	42	7	other	other	JJ
cord-005941-e4fvj54l	42	8	than	than	IN
cord-005941-e4fvj54l	42	9	the	the	DT
cord-005941-e4fvj54l	42	10	maintenance	maintenance	NN
cord-005941-e4fvj54l	42	11	of	of	IN
cord-005941-e4fvj54l	42	12	normal	normal	JJ
cord-005941-e4fvj54l	42	13	lung	lung	NN
cord-005941-e4fvj54l	42	14	function	function	NN
cord-005941-e4fvj54l	42	15	have	have	VBP
cord-005941-e4fvj54l	42	16	come	come	VBN
cord-005941-e4fvj54l	42	17	into	into	IN
cord-005941-e4fvj54l	42	18	view	view	NN
cord-005941-e4fvj54l	42	19	.	.	.
cord-005941-e4fvj54l	43	1	Perhaps	perhaps	RB
cord-005941-e4fvj54l	43	2	most	most	RBS
cord-005941-e4fvj54l	43	3	important	important	JJ
cord-005941-e4fvj54l	43	4	among	among	IN
cord-005941-e4fvj54l	43	5	these	these	DT
cord-005941-e4fvj54l	43	6	findings	finding	NNS
cord-005941-e4fvj54l	43	7	is	be	VBZ
cord-005941-e4fvj54l	43	8	that	that	IN
cord-005941-e4fvj54l	43	9	surfactant	surfactant	NN
cord-005941-e4fvj54l	43	10	plays	play	VBZ
cord-005941-e4fvj54l	43	11	a	a	DT
cord-005941-e4fvj54l	43	12	major	major	JJ
cord-005941-e4fvj54l	43	13	role	role	NN
cord-005941-e4fvj54l	43	14	in	in	IN
cord-005941-e4fvj54l	43	15	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	43	16	defense	defense	NN
cord-005941-e4fvj54l	43	17	mechanisms	mechanism	NNS
cord-005941-e4fvj54l	43	18	and	and	CC
cord-005941-e4fvj54l	43	19	local	local	JJ
cord-005941-e4fvj54l	43	20	immunomodulation	immunomodulation	NN
cord-005941-e4fvj54l	43	21	.	.	.
cord-005941-e4fvj54l	44	1	Therefore	therefore	RB
cord-005941-e4fvj54l	44	2	,	,	,
cord-005941-e4fvj54l	44	3	the	the	DT
cord-005941-e4fvj54l	44	4	role	role	NN
cord-005941-e4fvj54l	44	5	of	of	IN
cord-005941-e4fvj54l	44	6	surfactant	surfactant	NN
cord-005941-e4fvj54l	44	7	in	in	IN
cord-005941-e4fvj54l	44	8	different	different	JJ
cord-005941-e4fvj54l	44	9	lung	lung	NN
cord-005941-e4fvj54l	44	10	diseases	disease	NNS
cord-005941-e4fvj54l	44	11	and	and	CC
cord-005941-e4fvj54l	44	12	in	in	IN
cord-005941-e4fvj54l	44	13	the	the	DT
cord-005941-e4fvj54l	44	14	defense	defense	NN
cord-005941-e4fvj54l	44	15	against	against	IN
cord-005941-e4fvj54l	44	16	various	various	JJ
cord-005941-e4fvj54l	44	17	environmental	environmental	JJ
cord-005941-e4fvj54l	44	18	impacts	impact	NNS
cord-005941-e4fvj54l	44	19	on	on	IN
cord-005941-e4fvj54l	44	20	the	the	DT
cord-005941-e4fvj54l	44	21	respiratory	respiratory	JJ
cord-005941-e4fvj54l	44	22	tract	tract	NN
cord-005941-e4fvj54l	44	23	is	be	VBZ
cord-005941-e4fvj54l	44	24	attracting	attract	VBG
cord-005941-e4fvj54l	44	25	growing	grow	VBG
cord-005941-e4fvj54l	44	26	attention	attention	NN
cord-005941-e4fvj54l	44	27	.	.	.
cord-005941-e4fvj54l	45	1	The	the	DT
cord-005941-e4fvj54l	45	2	purpose	purpose	NN
cord-005941-e4fvj54l	45	3	of	of	IN
cord-005941-e4fvj54l	45	4	this	this	DT
cord-005941-e4fvj54l	45	5	article	article	NN
cord-005941-e4fvj54l	45	6	is	be	VBZ
cord-005941-e4fvj54l	45	7	to	to	TO
cord-005941-e4fvj54l	45	8	present	present	VB
cord-005941-e4fvj54l	45	9	a	a	DT
cord-005941-e4fvj54l	45	10	review	review	NN
cord-005941-e4fvj54l	45	11	of	of	IN
cord-005941-e4fvj54l	45	12	the	the	DT
cord-005941-e4fvj54l	45	13	current	current	JJ
cord-005941-e4fvj54l	45	14	knowledge	knowledge	NN
cord-005941-e4fvj54l	45	15	on	on	IN
cord-005941-e4fvj54l	45	16	the	the	DT
cord-005941-e4fvj54l	45	17	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	45	18	surfactant	surfactant	NN
cord-005941-e4fvj54l	45	19	system	system	NN
cord-005941-e4fvj54l	45	20	with	with	IN
cord-005941-e4fvj54l	45	21	emphasis	emphasis	NN
cord-005941-e4fvj54l	45	22	on	on	IN
cord-005941-e4fvj54l	45	23	possible	possible	JJ
cord-005941-e4fvj54l	45	24	clinical	clinical	JJ
cord-005941-e4fvj54l	45	25	implications	implication	NNS
cord-005941-e4fvj54l	45	26	and	and	CC
cord-005941-e4fvj54l	45	27	future	future	JJ
cord-005941-e4fvj54l	45	28	perspectives	perspective	NNS
cord-005941-e4fvj54l	45	29	for	for	IN
cord-005941-e4fvj54l	45	30	adult	adult	NN
cord-005941-e4fvj54l	45	31	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	45	32	medicine	medicine	NN
cord-005941-e4fvj54l	45	33	.	.	.
cord-005941-e4fvj54l	45	34	 	 	_SP
cord-005941-e4fvj54l	46	1	Surfactant	surfactant	NN
cord-005941-e4fvj54l	46	2	is	be	VBZ
cord-005941-e4fvj54l	46	3	a	a	DT
cord-005941-e4fvj54l	46	4	complex	complex	JJ
cord-005941-e4fvj54l	46	5	mixture	mixture	NN
cord-005941-e4fvj54l	46	6	of	of	IN
cord-005941-e4fvj54l	46	7	lipids	lipid	NNS
cord-005941-e4fvj54l	46	8	and	and	CC
cord-005941-e4fvj54l	46	9	proteins	protein	NNS
cord-005941-e4fvj54l	47	1	(	(	-LRB-
cord-005941-e4fvj54l	47	2	Fig	Fig	NNP
cord-005941-e4fvj54l	47	3	.	.	NNP
cord-005941-e4fvj54l	47	4	1	1	CD
cord-005941-e4fvj54l	47	5	)	)	-RRB-
cord-005941-e4fvj54l	47	6	.	.	.
cord-005941-e4fvj54l	48	1	Additionally	additionally	RB
cord-005941-e4fvj54l	48	2	,	,	,
cord-005941-e4fvj54l	48	3	carbohydrate	carbohydrate	NN
cord-005941-e4fvj54l	48	4	components	component	NNS
cord-005941-e4fvj54l	48	5	are	be	VBP
cord-005941-e4fvj54l	48	6	found	find	VBN
cord-005941-e4fvj54l	48	7	in	in	IN
cord-005941-e4fvj54l	48	8	both	both	CC
cord-005941-e4fvj54l	48	9	the	the	DT
cord-005941-e4fvj54l	48	10	lipid	lipid	NN
cord-005941-e4fvj54l	48	11	[	[	-LRB-
cord-005941-e4fvj54l	48	12	165	165	CD
cord-005941-e4fvj54l	48	13	]	]	-RRB-
cord-005941-e4fvj54l	48	14	and	and	CC
cord-005941-e4fvj54l	48	15	the	the	DT
cord-005941-e4fvj54l	48	16	protein	protein	NN
cord-005941-e4fvj54l	48	17	fractions	fraction	NNS
cord-005941-e4fvj54l	48	18	[	[	-LRB-
cord-005941-e4fvj54l	48	19	189	189	CD
cord-005941-e4fvj54l	48	20	]	]	-RRB-
cord-005941-e4fvj54l	48	21	,	,	,
cord-005941-e4fvj54l	48	22	but	but	CC
cord-005941-e4fvj54l	48	23	their	-PRON-	PRP$
cord-005941-e4fvj54l	48	24	precise	precise	JJ
cord-005941-e4fvj54l	48	25	functions	function	NNS
cord-005941-e4fvj54l	48	26	remain	remain	VBP
cord-005941-e4fvj54l	48	27	to	to	TO
cord-005941-e4fvj54l	48	28	be	be	VB
cord-005941-e4fvj54l	48	29	established	establish	VBN
cord-005941-e4fvj54l	48	30	.	.	.
cord-005941-e4fvj54l	49	1	Most	Most	JJS
cord-005941-e4fvj54l	49	2	of	of	IN
cord-005941-e4fvj54l	49	3	the	the	DT
cord-005941-e4fvj54l	49	4	present	present	JJ
cord-005941-e4fvj54l	49	5	data	data	NN
cord-005941-e4fvj54l	49	6	on	on	IN
cord-005941-e4fvj54l	49	7	surfactant	surfactant	NN
cord-005941-e4fvj54l	49	8	composition	composition	NN
cord-005941-e4fvj54l	49	9	is	be	VBZ
cord-005941-e4fvj54l	49	10	based	base	VBN
cord-005941-e4fvj54l	49	11	on	on	IN
cord-005941-e4fvj54l	49	12	analyses	analysis	NNS
cord-005941-e4fvj54l	49	13	of	of	IN
cord-005941-e4fvj54l	49	14	lung	lung	NN
cord-005941-e4fvj54l	49	15	lavages	lavage	NNS
cord-005941-e4fvj54l	49	16	[	[	-LRB-
cord-005941-e4fvj54l	49	17	65	65	CD
cord-005941-e4fvj54l	49	18	,	,	,
cord-005941-e4fvj54l	49	19	174	174	CD
cord-005941-e4fvj54l	49	20	]	]	-RRB-
cord-005941-e4fvj54l	49	21	,	,	,
cord-005941-e4fvj54l	49	22	which	which	WDT
cord-005941-e4fvj54l	49	23	are	be	VBP
cord-005941-e4fvj54l	49	24	thought	think	VBN
cord-005941-e4fvj54l	49	25	to	to	TO
cord-005941-e4fvj54l	49	26	reflect	reflect	VB
cord-005941-e4fvj54l	49	27	adequately	adequately	RB
cord-005941-e4fvj54l	49	28	the	the	DT
cord-005941-e4fvj54l	49	29	situation	situation	NN
cord-005941-e4fvj54l	49	30	in	in	IN
cord-005941-e4fvj54l	49	31	the	the	DT
cord-005941-e4fvj54l	49	32	alveolar	alveolar	NN
cord-005941-e4fvj54l	49	33	lining	lining	NN
cord-005941-e4fvj54l	49	34	fluid	fluid	NN
cord-005941-e4fvj54l	49	35	.	.	.
cord-005941-e4fvj54l	50	1	However	however	RB
cord-005941-e4fvj54l	50	2	,	,	,
cord-005941-e4fvj54l	50	3	it	-PRON-	PRP
cord-005941-e4fvj54l	50	4	has	have	VBZ
cord-005941-e4fvj54l	50	5	to	to	TO
cord-005941-e4fvj54l	50	6	be	be	VB
cord-005941-e4fvj54l	50	7	kept	keep	VBN
cord-005941-e4fvj54l	50	8	in	in	IN
cord-005941-e4fvj54l	50	9	mind	mind	NN
cord-005941-e4fvj54l	50	10	that	that	IN
cord-005941-e4fvj54l	50	11	lavage	lavage	NN
cord-005941-e4fvj54l	50	12	specimens	specimen	NNS
cord-005941-e4fvj54l	50	13	may	may	MD
cord-005941-e4fvj54l	50	14	to	to	IN
cord-005941-e4fvj54l	50	15	some	some	DT
cord-005941-e4fvj54l	50	16	degree	degree	NN
cord-005941-e4fvj54l	50	17	be	be	VB
cord-005941-e4fvj54l	50	18	contaminated	contaminate	VBN
cord-005941-e4fvj54l	50	19	with	with	IN
cord-005941-e4fvj54l	50	20	lipids	lipid	NNS
cord-005941-e4fvj54l	50	21	of	of	IN
cord-005941-e4fvj54l	50	22	nonsurfactant	nonsurfactant	JJ
cord-005941-e4fvj54l	50	23	origin	origin	NN
cord-005941-e4fvj54l	50	24	,	,	,
cord-005941-e4fvj54l	50	25	e.g.	e.g.	RB
cord-005941-e4fvj54l	50	26	,	,	,
cord-005941-e4fvj54l	50	27	lipids	lipid	NNS
cord-005941-e4fvj54l	50	28	stemming	stem	VBG
cord-005941-e4fvj54l	50	29	from	from	IN
cord-005941-e4fvj54l	50	30	cell	cell	NN
cord-005941-e4fvj54l	50	31	membranes	membrane	NNS
cord-005941-e4fvj54l	50	32	or	or	CC
cord-005941-e4fvj54l	50	33	lipids	lipid	NNS
cord-005941-e4fvj54l	50	34	secreted	secrete	VBN
cord-005941-e4fvj54l	50	35	by	by	IN
cord-005941-e4fvj54l	50	36	airway	airway	NN
cord-005941-e4fvj54l	50	37	epithelial	epithelial	JJ
cord-005941-e4fvj54l	50	38	cells	cell	NNS
cord-005941-e4fvj54l	50	39	[	[	-LRB-
cord-005941-e4fvj54l	50	40	93	93	CD
cord-005941-e4fvj54l	50	41	]	]	-RRB-
cord-005941-e4fvj54l	50	42	.	.	.
cord-005941-e4fvj54l	51	1	Fewer	few	JJR
cord-005941-e4fvj54l	51	2	data	datum	NNS
cord-005941-e4fvj54l	51	3	exist	exist	VBP
cord-005941-e4fvj54l	51	4	on	on	IN
cord-005941-e4fvj54l	51	5	the	the	DT
cord-005941-e4fvj54l	51	6	intracellular	intracellular	JJ
cord-005941-e4fvj54l	51	7	surfactant	surfactant	NN
cord-005941-e4fvj54l	51	8	composition	composition	NN
cord-005941-e4fvj54l	51	9	,	,	,
cord-005941-e4fvj54l	51	10	e.g.	e.g.	RB
cord-005941-e4fvj54l	51	11	,	,	,
cord-005941-e4fvj54l	51	12	in	in	IN
cord-005941-e4fvj54l	51	13	the	the	DT
cord-005941-e4fvj54l	51	14	lamellar	lamellar	JJ
cord-005941-e4fvj54l	51	15	bodies	body	NNS
cord-005941-e4fvj54l	51	16	of	of	IN
cord-005941-e4fvj54l	51	17	alveolar	alveolar	JJ
cord-005941-e4fvj54l	51	18	type	type	NN
cord-005941-e4fvj54l	51	19	II	ii	CD
cord-005941-e4fvj54l	51	20	cells	cell	NNS
cord-005941-e4fvj54l	51	21	.	.	.
cord-005941-e4fvj54l	52	1	However	however	RB
cord-005941-e4fvj54l	52	2	,	,	,
cord-005941-e4fvj54l	52	3	the	the	DT
cord-005941-e4fvj54l	52	4	surfactant	surfactant	NN
cord-005941-e4fvj54l	52	5	composition	composition	NN
cord-005941-e4fvj54l	52	6	of	of	IN
cord-005941-e4fvj54l	52	7	the	the	DT
cord-005941-e4fvj54l	52	8	intra	intra	JJ
cord-005941-e4fvj54l	52	9	-	-	JJ
cord-005941-e4fvj54l	52	10	and	and	CC
cord-005941-e4fvj54l	52	11	extracellular	extracellular	JJ
cord-005941-e4fvj54l	52	12	compartments	compartment	NNS
cord-005941-e4fvj54l	52	13	seems	seem	VBZ
cord-005941-e4fvj54l	52	14	to	to	TO
cord-005941-e4fvj54l	52	15	be	be	VB
cord-005941-e4fvj54l	52	16	similar	similar	JJ
cord-005941-e4fvj54l	52	17	[	[	-LRB-
cord-005941-e4fvj54l	52	18	55	55	CD
cord-005941-e4fvj54l	52	19	,	,	,
cord-005941-e4fvj54l	52	20	65	65	CD
cord-005941-e4fvj54l	52	21	]	]	-RRB-
cord-005941-e4fvj54l	52	22	.	.	.
cord-005941-e4fvj54l	53	1	The	the	DT
cord-005941-e4fvj54l	53	2	pool	pool	NN
cord-005941-e4fvj54l	53	3	size	size	NN
cord-005941-e4fvj54l	53	4	of	of	IN
cord-005941-e4fvj54l	53	5	extracellular	extracellular	JJ
cord-005941-e4fvj54l	53	6	surfactant	surfactant	NN
cord-005941-e4fvj54l	53	7	has	have	VBZ
cord-005941-e4fvj54l	53	8	been	be	VBN
cord-005941-e4fvj54l	53	9	investigated	investigate	VBN
cord-005941-e4fvj54l	53	10	in	in	IN
cord-005941-e4fvj54l	53	11	animals	animal	NNS
cord-005941-e4fvj54l	53	12	and	and	CC
cord-005941-e4fvj54l	53	13	ranges	range	VBZ
cord-005941-e4fvj54l	53	14	from	from	IN
cord-005941-e4fvj54l	53	15	about	about	RB
cord-005941-e4fvj54l	53	16	10	10	CD
cord-005941-e4fvj54l	53	17	-	-	SYM
cord-005941-e4fvj54l	53	18	15	15	CD
cord-005941-e4fvj54l	53	19	mg	mg	NNP
cord-005941-e4fvj54l	53	20	/	/	SYM
cord-005941-e4fvj54l	53	21	kg	kg	NN
cord-005941-e4fvj54l	53	22	body	body	NN
cord-005941-e4fvj54l	53	23	weight	weight	NN
cord-005941-e4fvj54l	53	24	in	in	IN
cord-005941-e4fvj54l	53	25	adults	adult	NNS
cord-005941-e4fvj54l	53	26	.	.	.
cord-005941-e4fvj54l	54	1	Mature	mature	JJ
cord-005941-e4fvj54l	54	2	newborns	newborn	NNS
cord-005941-e4fvj54l	54	3	have	have	VBP
cord-005941-e4fvj54l	54	4	5-to	5-to	CD
cord-005941-e4fvj54l	54	5	10-fold	10-fold	CD
cord-005941-e4fvj54l	54	6	higher	high	JJR
cord-005941-e4fvj54l	54	7	values	value	NNS
cord-005941-e4fvj54l	54	8	[	[	-LRB-
cord-005941-e4fvj54l	54	9	83	83	CD
cord-005941-e4fvj54l	54	10	]	]	-RRB-
cord-005941-e4fvj54l	54	11	.	.	.
cord-005941-e4fvj54l	55	1	Assuming	assume	VBG
cord-005941-e4fvj54l	55	2	similar	similar	JJ
cord-005941-e4fvj54l	55	3	values	value	NNS
cord-005941-e4fvj54l	55	4	in	in	IN
cord-005941-e4fvj54l	55	5	man	man	NN
cord-005941-e4fvj54l	55	6	,	,	,
cord-005941-e4fvj54l	55	7	a	a	DT
cord-005941-e4fvj54l	55	8	70	70	CD
cord-005941-e4fvj54l	55	9	kg	kg	NN
cord-005941-e4fvj54l	55	10	person	person	NN
cord-005941-e4fvj54l	55	11	would	would	MD
cord-005941-e4fvj54l	55	12	thus	thus	RB
cord-005941-e4fvj54l	55	13	have	have	VB
cord-005941-e4fvj54l	55	14	an	an	DT
cord-005941-e4fvj54l	55	15	estimated	estimate	VBN
cord-005941-e4fvj54l	55	16	alveolar	alveolar	NN
cord-005941-e4fvj54l	55	17	surfactant	surfactant	NN
cord-005941-e4fvj54l	55	18	pool	pool	NN
cord-005941-e4fvj54l	55	19	of	of	IN
cord-005941-e4fvj54l	55	20	approximately	approximately	RB
cord-005941-e4fvj54l	55	21	0.7	0.7	CD
cord-005941-e4fvj54l	55	22	-	-	SYM
cord-005941-e4fvj54l	55	23	1.0	1.0	CD
cord-005941-e4fvj54l	55	24	g.	g.	NN
cord-005941-e4fvj54l	56	1	However	however	RB
cord-005941-e4fvj54l	56	2	,	,	,
cord-005941-e4fvj54l	56	3	there	there	EX
cord-005941-e4fvj54l	56	4	are	be	VBP
cord-005941-e4fvj54l	56	5	no	no	DT
cord-005941-e4fvj54l	56	6	available	available	JJ
cord-005941-e4fvj54l	56	7	data	datum	NNS
cord-005941-e4fvj54l	56	8	on	on	IN
cord-005941-e4fvj54l	56	9	the	the	DT
cord-005941-e4fvj54l	56	10	normal	normal	JJ
cord-005941-e4fvj54l	56	11	surfactant	surfactant	NN
cord-005941-e4fvj54l	56	12	pool	pool	NN
cord-005941-e4fvj54l	56	13	size	size	NN
cord-005941-e4fvj54l	56	14	in	in	IN
cord-005941-e4fvj54l	56	15	man	man	NN
cord-005941-e4fvj54l	56	16	,	,	,
cord-005941-e4fvj54l	56	17	and	and	CC
cord-005941-e4fvj54l	56	18	there	there	EX
cord-005941-e4fvj54l	56	19	may	may	MD
cord-005941-e4fvj54l	56	20	possibly	possibly	RB
cord-005941-e4fvj54l	56	21	be	be	VB
cord-005941-e4fvj54l	56	22	considerable	considerable	JJ
cord-005941-e4fvj54l	56	23	interindividual	interindividual	JJ
cord-005941-e4fvj54l	56	24	variations	variation	NNS
cord-005941-e4fvj54l	56	25	.	.	.
cord-005941-e4fvj54l	57	1	Lipids	lipid	NNS
cord-005941-e4fvj54l	57	2	are	be	VBP
cord-005941-e4fvj54l	57	3	the	the	DT
cord-005941-e4fvj54l	57	4	major	major	JJ
cord-005941-e4fvj54l	57	5	surfactant	surfactant	NN
cord-005941-e4fvj54l	57	6	component	component	NN
cord-005941-e4fvj54l	57	7	by	by	IN
cord-005941-e4fvj54l	57	8	weight	weight	NN
cord-005941-e4fvj54l	57	9	(	(	-LRB-
cord-005941-e4fvj54l	57	10	Fig	Fig	NNP
cord-005941-e4fvj54l	57	11	.	.	.
cord-005941-e4fvj54l	57	12	1	1	CD
cord-005941-e4fvj54l	57	13	)	)	-RRB-
cord-005941-e4fvj54l	57	14	.	.	.
cord-005941-e4fvj54l	58	1	They	-PRON-	PRP
cord-005941-e4fvj54l	58	2	make	make	VBP
cord-005941-e4fvj54l	58	3	up	up	RP
cord-005941-e4fvj54l	58	4	about	about	RB
cord-005941-e4fvj54l	58	5	85%-90	85%-90	CD
cord-005941-e4fvj54l	58	6	%	%	NN
cord-005941-e4fvj54l	58	7	of	of	IN
cord-005941-e4fvj54l	58	8	whole	whole	JJ
cord-005941-e4fvj54l	58	9	isolated	isolate	VBN
cord-005941-e4fvj54l	58	10	surfactant	surfactant	NN
cord-005941-e4fvj54l	58	11	[	[	-LRB-
cord-005941-e4fvj54l	58	12	65	65	CD
cord-005941-e4fvj54l	58	13	]	]	-RRB-
cord-005941-e4fvj54l	58	14	.	.	.
cord-005941-e4fvj54l	59	1	Approximately	approximately	RB
cord-005941-e4fvj54l	59	2	90	90	CD
cord-005941-e4fvj54l	59	3	%	%	NN
cord-005941-e4fvj54l	59	4	of	of	IN
cord-005941-e4fvj54l	59	5	this	this	DT
cord-005941-e4fvj54l	59	6	lipid	lipid	NN
cord-005941-e4fvj54l	59	7	fraction	fraction	NN
cord-005941-e4fvj54l	59	8	consists	consist	VBZ
cord-005941-e4fvj54l	59	9	of	of	IN
cord-005941-e4fvj54l	59	10	a	a	DT
cord-005941-e4fvj54l	59	11	mixture	mixture	NN
cord-005941-e4fvj54l	59	12	of	of	IN
cord-005941-e4fvj54l	59	13	phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	59	14	.	.	.
cord-005941-e4fvj54l	60	1	The	the	DT
cord-005941-e4fvj54l	60	2	remaining	remain	VBG
cord-005941-e4fvj54l	60	3	10	10	CD
cord-005941-e4fvj54l	60	4	%	%	NN
cord-005941-e4fvj54l	60	5	are	be	VBP
cord-005941-e4fvj54l	60	6	composed	compose	VBN
cord-005941-e4fvj54l	60	7	of	of	IN
cord-005941-e4fvj54l	60	8	other	other	JJ
cord-005941-e4fvj54l	60	9	lipids	lipid	NNS
cord-005941-e4fvj54l	60	10	,	,	,
cord-005941-e4fvj54l	60	11	mainly	mainly	RB
cord-005941-e4fvj54l	60	12	cholesterol	cholesterol	NN
cord-005941-e4fvj54l	60	13	,	,	,
cord-005941-e4fvj54l	60	14	which	which	WDT
cord-005941-e4fvj54l	60	15	seems	seem	VBZ
cord-005941-e4fvj54l	60	16	to	to	TO
cord-005941-e4fvj54l	60	17	be	be	VB
cord-005941-e4fvj54l	60	18	blood	blood	NN
cord-005941-e4fvj54l	60	19	-	-	HYPH
cord-005941-e4fvj54l	60	20	derived	derive	VBN
cord-005941-e4fvj54l	60	21	and	and	CC
cord-005941-e4fvj54l	60	22	is	be	VBZ
cord-005941-e4fvj54l	60	23	of	of	IN
cord-005941-e4fvj54l	60	24	uncertain	uncertain	JJ
cord-005941-e4fvj54l	60	25	functional	functional	JJ
cord-005941-e4fvj54l	60	26	significance	significance	NN
cord-005941-e4fvj54l	60	27	[	[	-LRB-
cord-005941-e4fvj54l	60	28	66	66	CD
cord-005941-e4fvj54l	60	29	]	]	-RRB-
cord-005941-e4fvj54l	60	30	.	.	.
cord-005941-e4fvj54l	61	1	Phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	61	2	combine	combine	VBP
cord-005941-e4fvj54l	61	3	hydrophobic	hydrophobic	JJ
cord-005941-e4fvj54l	61	4	and	and	CC
cord-005941-e4fvj54l	61	5	hydrophilic	hydrophilic	JJ
cord-005941-e4fvj54l	61	6	properties	property	NNS
cord-005941-e4fvj54l	61	7	and	and	CC
cord-005941-e4fvj54l	61	8	are	be	VBP
cord-005941-e4fvj54l	61	9	therefore	therefore	RB
cord-005941-e4fvj54l	61	10	involved	involve	VBN
cord-005941-e4fvj54l	61	11	in	in	IN
cord-005941-e4fvj54l	61	12	the	the	DT
cord-005941-e4fvj54l	61	13	coating	coating	NN
cord-005941-e4fvj54l	61	14	of	of	IN
cord-005941-e4fvj54l	61	15	boundary	boundary	JJ
cord-005941-e4fvj54l	61	16	areas	area	NNS
cord-005941-e4fvj54l	61	17	and	and	CC
cord-005941-e4fvj54l	61	18	surfaces	surface	NNS
cord-005941-e4fvj54l	61	19	.	.	.
cord-005941-e4fvj54l	62	1	They	-PRON-	PRP
cord-005941-e4fvj54l	62	2	possess	possess	VBP
cord-005941-e4fvj54l	62	3	the	the	DT
cord-005941-e4fvj54l	62	4	ability	ability	NN
cord-005941-e4fvj54l	62	5	to	to	TO
cord-005941-e4fvj54l	62	6	achieve	achieve	VB
cord-005941-e4fvj54l	62	7	low	low	JJ
cord-005941-e4fvj54l	62	8	surface	surface	NN
cord-005941-e4fvj54l	62	9	tensions	tension	NNS
cord-005941-e4fvj54l	62	10	at	at	IN
cord-005941-e4fvj54l	62	11	air	air	NN
cord-005941-e4fvj54l	62	12	-	-	HYPH
cord-005941-e4fvj54l	62	13	liquid	liquid	NN
cord-005941-e4fvj54l	62	14	interfaces	interface	NNS
cord-005941-e4fvj54l	62	15	and	and	CC
cord-005941-e4fvj54l	62	16	support	support	NN
cord-005941-e4fvj54l	62	17	,	,	,
cord-005941-e4fvj54l	62	18	for	for	IN
cord-005941-e4fvj54l	62	19	example	example	NN
cord-005941-e4fvj54l	62	20	,	,	,
cord-005941-e4fvj54l	62	21	the	the	DT
cord-005941-e4fvj54l	62	22	formation	formation	NN
cord-005941-e4fvj54l	62	23	of	of	IN
cord-005941-e4fvj54l	62	24	micelles	micelle	NNS
cord-005941-e4fvj54l	62	25	and	and	CC
cord-005941-e4fvj54l	62	26	lamellae	lamella	NNS
cord-005941-e4fvj54l	62	27	.	.	.
cord-005941-e4fvj54l	63	1	However	however	RB
cord-005941-e4fvj54l	63	2	,	,	,
cord-005941-e4fvj54l	63	3	phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	63	4	not	not	RB
cord-005941-e4fvj54l	63	5	only	only	RB
cord-005941-e4fvj54l	63	6	have	have	VBP
cord-005941-e4fvj54l	63	7	structural	structural	JJ
cord-005941-e4fvj54l	63	8	functions	function	NNS
cord-005941-e4fvj54l	63	9	but	but	CC
cord-005941-e4fvj54l	63	10	may	may	MD
cord-005941-e4fvj54l	63	11	in	in	IN
cord-005941-e4fvj54l	63	12	many	many	JJ
cord-005941-e4fvj54l	63	13	ways	way	NNS
cord-005941-e4fvj54l	63	14	be	be	VB
cord-005941-e4fvj54l	63	15	involved	involve	VBN
cord-005941-e4fvj54l	63	16	in	in	IN
cord-005941-e4fvj54l	63	17	different	different	JJ
cord-005941-e4fvj54l	63	18	dynamic	dynamic	JJ
cord-005941-e4fvj54l	63	19	biological	biological	JJ
cord-005941-e4fvj54l	63	20	processes	process	NNS
cord-005941-e4fvj54l	63	21	[	[	-LRB-
cord-005941-e4fvj54l	63	22	64	64	CD
cord-005941-e4fvj54l	63	23	]	]	-RRB-
cord-005941-e4fvj54l	63	24	.	.	.
cord-005941-e4fvj54l	64	1	The	the	DT
cord-005941-e4fvj54l	64	2	phospholipid	phospholipid	NN
cord-005941-e4fvj54l	64	3	composition	composition	NN
cord-005941-e4fvj54l	64	4	of	of	IN
cord-005941-e4fvj54l	64	5	human	human	JJ
cord-005941-e4fvj54l	64	6	lung	lung	NN
cord-005941-e4fvj54l	64	7	surfactant	surfactant	NN
cord-005941-e4fvj54l	64	8	is	be	VBZ
cord-005941-e4fvj54l	64	9	shown	show	VBN
cord-005941-e4fvj54l	64	10	in	in	IN
cord-005941-e4fvj54l	64	11	Fig	Fig	NNP
cord-005941-e4fvj54l	64	12	.	.	.
cord-005941-e4fvj54l	65	1	1	1	LS
cord-005941-e4fvj54l	65	2	.	.	.
cord-005941-e4fvj54l	66	1	In	in	IN
cord-005941-e4fvj54l	66	2	other	other	JJ
cord-005941-e4fvj54l	66	3	mammals	mammal	NNS
cord-005941-e4fvj54l	66	4	,	,	,
cord-005941-e4fvj54l	66	5	this	this	DT
cord-005941-e4fvj54l	66	6	distribution	distribution	NN
cord-005941-e4fvj54l	66	7	is	be	VBZ
cord-005941-e4fvj54l	66	8	very	very	RB
cord-005941-e4fvj54l	66	9	much	much	RB
cord-005941-e4fvj54l	66	10	the	the	DT
cord-005941-e4fvj54l	66	11	same	same	JJ
cord-005941-e4fvj54l	66	12	.	.	.
cord-005941-e4fvj54l	67	1	None	none	NN
cord-005941-e4fvj54l	67	2	of	of	IN
cord-005941-e4fvj54l	67	3	these	these	DT
cord-005941-e4fvj54l	67	4	phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	67	5	is	be	VBZ
cord-005941-e4fvj54l	67	6	unique	unique	JJ
cord-005941-e4fvj54l	67	7	to	to	IN
cord-005941-e4fvj54l	67	8	surfactant	surfactant	NN
cord-005941-e4fvj54l	67	9	,	,	,
cord-005941-e4fvj54l	67	10	but	but	CC
cord-005941-e4fvj54l	67	11	in	in	IN
cord-005941-e4fvj54l	67	12	contrast	contrast	NN
cord-005941-e4fvj54l	67	13	to	to	IN
cord-005941-e4fvj54l	67	14	the	the	DT
cord-005941-e4fvj54l	67	15	phospholipid	phospholipid	NN
cord-005941-e4fvj54l	67	16	profile	profile	NN
cord-005941-e4fvj54l	67	17	in	in	IN
cord-005941-e4fvj54l	67	18	other	other	JJ
cord-005941-e4fvj54l	67	19	organs	organ	NNS
cord-005941-e4fvj54l	67	20	,	,	,
cord-005941-e4fvj54l	67	21	the	the	DT
cord-005941-e4fvj54l	67	22	relative	relative	JJ
cord-005941-e4fvj54l	67	23	concentrations	concentration	NNS
cord-005941-e4fvj54l	67	24	of	of	IN
cord-005941-e4fvj54l	67	25	phospatidylcholine	phospatidylcholine	JJ
cord-005941-e4fvj54l	67	26	and	and	CC
cord-005941-e4fvj54l	67	27	phosphatidylglycerol	phosphatidylglycerol	NNP
cord-005941-e4fvj54l	67	28	are	be	VBP
cord-005941-e4fvj54l	67	29	higher	high	JJR
cord-005941-e4fvj54l	67	30	.	.	.
cord-005941-e4fvj54l	68	1	Surfactants	surfactant	NNS
cord-005941-e4fvj54l	68	2	of	of	IN
cord-005941-e4fvj54l	68	3	amphibians	amphibian	NNS
cord-005941-e4fvj54l	68	4	and	and	CC
cord-005941-e4fvj54l	68	5	birds	bird	NNS
cord-005941-e4fvj54l	68	6	lack	lack	VBP
cord-005941-e4fvj54l	68	7	phosphatidylglycerol	phosphatidylglycerol	JJ
cord-005941-e4fvj54l	68	8	,	,	,
cord-005941-e4fvj54l	68	9	suggesting	suggest	VBG
cord-005941-e4fvj54l	68	10	that	that	IN
cord-005941-e4fvj54l	68	11	this	this	DT
cord-005941-e4fvj54l	68	12	phospholipid	phospholipid	NN
cord-005941-e4fvj54l	68	13	was	be	VBD
cord-005941-e4fvj54l	68	14	introduced	introduce	VBN
cord-005941-e4fvj54l	68	15	late	late	RB
cord-005941-e4fvj54l	68	16	in	in	IN
cord-005941-e4fvj54l	68	17	evolution	evolution	NN
cord-005941-e4fvj54l	68	18	[	[	-LRB-
cord-005941-e4fvj54l	68	19	65	65	CD
cord-005941-e4fvj54l	68	20	]	]	-RRB-
cord-005941-e4fvj54l	68	21	.	.	.
cord-005941-e4fvj54l	69	1	In	in	IN
cord-005941-e4fvj54l	69	2	human	human	JJ
cord-005941-e4fvj54l	69	3	fetal	fetal	JJ
cord-005941-e4fvj54l	69	4	lung	lung	NN
cord-005941-e4fvj54l	69	5	development	development	NN
cord-005941-e4fvj54l	69	6	,	,	,
cord-005941-e4fvj54l	69	7	phosphatidylglycerol	phosphatidylglycerol	NNP
cord-005941-e4fvj54l	69	8	becomes	become	VBZ
cord-005941-e4fvj54l	69	9	detectable	detectable	JJ
cord-005941-e4fvj54l	69	10	only	only	RB
cord-005941-e4fvj54l	69	11	late	late	RB
cord-005941-e4fvj54l	69	12	in	in	IN
cord-005941-e4fvj54l	69	13	pregnancy	pregnancy	NN
cord-005941-e4fvj54l	69	14	and	and	CC
cord-005941-e4fvj54l	69	15	may	may	MD
cord-005941-e4fvj54l	69	16	serve	serve	VB
cord-005941-e4fvj54l	69	17	as	as	IN
cord-005941-e4fvj54l	69	18	an	an	DT
cord-005941-e4fvj54l	69	19	indicator	indicator	NN
cord-005941-e4fvj54l	69	20	of	of	IN
cord-005941-e4fvj54l	69	21	fetal	fetal	JJ
cord-005941-e4fvj54l	69	22	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	69	23	maturity	maturity	NN
cord-005941-e4fvj54l	69	24	[	[	-LRB-
cord-005941-e4fvj54l	69	25	59	59	CD
cord-005941-e4fvj54l	69	26	]	]	-RRB-
cord-005941-e4fvj54l	69	27	,	,	,
cord-005941-e4fvj54l	69	28	although	although	IN
cord-005941-e4fvj54l	69	29	it	-PRON-	PRP
cord-005941-e4fvj54l	69	30	does	do	VBZ
cord-005941-e4fvj54l	69	31	not	not	RB
cord-005941-e4fvj54l	69	32	seem	seem	VB
cord-005941-e4fvj54l	69	33	to	to	TO
cord-005941-e4fvj54l	69	34	contribute	contribute	VB
cord-005941-e4fvj54l	69	35	to	to	IN
cord-005941-e4fvj54l	69	36	the	the	DT
cord-005941-e4fvj54l	69	37	reduction	reduction	NN
cord-005941-e4fvj54l	69	38	of	of	IN
cord-005941-e4fvj54l	69	39	alveolar	alveolar	JJ
cord-005941-e4fvj54l	69	40	surface	surface	NN
cord-005941-e4fvj54l	69	41	tension	tension	NN
cord-005941-e4fvj54l	69	42	[	[	-LRB-
cord-005941-e4fvj54l	69	43	15	15	CD
cord-005941-e4fvj54l	69	44	]	]	-RRB-
cord-005941-e4fvj54l	69	45	.	.	.
cord-005941-e4fvj54l	70	1	Phosphatidylcholine	Phosphatidylcholine	NNP
cord-005941-e4fvj54l	70	2	accounts	account	VBZ
cord-005941-e4fvj54l	70	3	for	for	IN
cord-005941-e4fvj54l	70	4	approximately	approximately	RB
cord-005941-e4fvj54l	70	5	80	80	CD
cord-005941-e4fvj54l	70	6	%	%	NN
cord-005941-e4fvj54l	70	7	of	of	IN
cord-005941-e4fvj54l	70	8	total	total	JJ
cord-005941-e4fvj54l	70	9	surfactant	surfactant	NN
cord-005941-e4fvj54l	70	10	phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	70	11	and	and	CC
cord-005941-e4fvj54l	70	12	for	for	IN
cord-005941-e4fvj54l	70	13	about	about	RB
cord-005941-e4fvj54l	70	14	two	two	CD
cord-005941-e4fvj54l	70	15	-	-	HYPH
cord-005941-e4fvj54l	70	16	thirds	third	NNS
cord-005941-e4fvj54l	70	17	of	of	IN
cord-005941-e4fvj54l	70	18	whole	whole	JJ
cord-005941-e4fvj54l	70	19	surfactant	surfactant	NN
cord-005941-e4fvj54l	70	20	(	(	-LRB-
cord-005941-e4fvj54l	70	21	Fig	Fig	NNP
cord-005941-e4fvj54l	70	22	.	.	.
cord-005941-e4fvj54l	70	23	1	1	CD
cord-005941-e4fvj54l	70	24	)	)	-RRB-
cord-005941-e4fvj54l	70	25	.	.	.
cord-005941-e4fvj54l	71	1	Approximately	approximately	RB
cord-005941-e4fvj54l	71	2	70	70	CD
cord-005941-e4fvj54l	71	3	%	%	NN
cord-005941-e4fvj54l	71	4	of	of	IN
cord-005941-e4fvj54l	71	5	its	-PRON-	PRP$
cord-005941-e4fvj54l	71	6	fatty	fatty	JJ
cord-005941-e4fvj54l	71	7	acids	acid	NNS
cord-005941-e4fvj54l	71	8	are	be	VBP
cord-005941-e4fvj54l	71	9	saturated	saturate	VBN
cord-005941-e4fvj54l	71	10	under	under	IN
cord-005941-e4fvj54l	71	11	normal	normal	JJ
cord-005941-e4fvj54l	71	12	conditions	condition	NNS
cord-005941-e4fvj54l	71	13	[	[	-LRB-
cord-005941-e4fvj54l	71	14	65	65	CD
cord-005941-e4fvj54l	71	15	]	]	-RRB-
cord-005941-e4fvj54l	71	16	,	,	,
cord-005941-e4fvj54l	71	17	the	the	DT
cord-005941-e4fvj54l	71	18	most	most	RBS
cord-005941-e4fvj54l	71	19	common	common	JJ
cord-005941-e4fvj54l	71	20	saturated	saturated	JJ
cord-005941-e4fvj54l	71	21	acid	acid	NN
cord-005941-e4fvj54l	71	22	being	be	VBG
cord-005941-e4fvj54l	71	23	palmitic	palmitic	JJ
cord-005941-e4fvj54l	71	24	acid	acid	NN
cord-005941-e4fvj54l	71	25	.	.	.
cord-005941-e4fvj54l	72	1	Dipalmitoylphosphatidylcholine	Dipalmitoylphosphatidylcholine	NNP
cord-005941-e4fvj54l	72	2	(	(	-LRB-
cord-005941-e4fvj54l	72	3	DPPC	DPPC	NNP
cord-005941-e4fvj54l	72	4	)	)	-RRB-
cord-005941-e4fvj54l	72	5	is	be	VBZ
cord-005941-e4fvj54l	72	6	the	the	DT
cord-005941-e4fvj54l	72	7	surfactant	surfactant	NN
cord-005941-e4fvj54l	72	8	component	component	NN
cord-005941-e4fvj54l	72	9	which	which	WDT
cord-005941-e4fvj54l	72	10	is	be	VBZ
cord-005941-e4fvj54l	72	11	predominantly	predominantly	RB
cord-005941-e4fvj54l	72	12	responsible	responsible	JJ
cord-005941-e4fvj54l	72	13	for	for	IN
cord-005941-e4fvj54l	72	14	the	the	DT
cord-005941-e4fvj54l	72	15	reduction	reduction	NN
cord-005941-e4fvj54l	72	16	of	of	IN
cord-005941-e4fvj54l	72	17	alveolar	alveolar	JJ
cord-005941-e4fvj54l	72	18	surface	surface	NN
cord-005941-e4fvj54l	72	19	tension	tension	NN
cord-005941-e4fvj54l	72	20	[	[	-LRB-
cord-005941-e4fvj54l	72	21	9	9	CD
cord-005941-e4fvj54l	72	22	]	]	-RRB-
cord-005941-e4fvj54l	72	23	.	.	.
cord-005941-e4fvj54l	73	1	Its	-PRON-	PRP$
cord-005941-e4fvj54l	73	2	hydrophilic	hydrophilic	JJ
cord-005941-e4fvj54l	73	3	(	(	-LRB-
cord-005941-e4fvj54l	73	4	choline	choline	NN
cord-005941-e4fvj54l	73	5	)	)	-RRB-
cord-005941-e4fvj54l	73	6	residue	residue	NN
cord-005941-e4fvj54l	73	7	associates	associate	NNS
cord-005941-e4fvj54l	73	8	with	with	IN
cord-005941-e4fvj54l	73	9	the	the	DT
cord-005941-e4fvj54l	73	10	alveolar	alveolar	JJ
cord-005941-e4fvj54l	73	11	liquid	liquid	NN
cord-005941-e4fvj54l	73	12	phase	phase	NN
cord-005941-e4fvj54l	73	13	while	while	IN
cord-005941-e4fvj54l	73	14	the	the	DT
cord-005941-e4fvj54l	73	15	hydrophobic	hydrophobic	JJ
cord-005941-e4fvj54l	73	16	(	(	-LRB-
cord-005941-e4fvj54l	73	17	palmitic	palmitic	JJ
cord-005941-e4fvj54l	73	18	acid	acid	NN
cord-005941-e4fvj54l	73	19	)	)	-RRB-
cord-005941-e4fvj54l	73	20	residue	residue	NN
cord-005941-e4fvj54l	73	21	reaches	reach	VBZ
cord-005941-e4fvj54l	73	22	into	into	IN
cord-005941-e4fvj54l	73	23	the	the	DT
cord-005941-e4fvj54l	73	24	air	air	NN
cord-005941-e4fvj54l	73	25	phase	phase	NN
cord-005941-e4fvj54l	73	26	[	[	-LRB-
cord-005941-e4fvj54l	73	27	197	197	CD
cord-005941-e4fvj54l	73	28	]	]	-RRB-
cord-005941-e4fvj54l	73	29	.	.	.
cord-005941-e4fvj54l	74	1	Pattle	pattle	NN
cord-005941-e4fvj54l	74	2	[	[	-LRB-
cord-005941-e4fvj54l	74	3	135	135	CD
cord-005941-e4fvj54l	74	4	]	]	-RRB-
cord-005941-e4fvj54l	74	5	first	first	RB
cord-005941-e4fvj54l	74	6	noted	note	VBD
cord-005941-e4fvj54l	74	7	that	that	IN
cord-005941-e4fvj54l	74	8	a	a	DT
cord-005941-e4fvj54l	74	9	protein	protein	NN
cord-005941-e4fvj54l	74	10	component	component	NN
cord-005941-e4fvj54l	74	11	in	in	IN
cord-005941-e4fvj54l	74	12	surfactant	surfactant	NN
cord-005941-e4fvj54l	74	13	material	material	NN
cord-005941-e4fvj54l	74	14	seemed	seem	VBD
cord-005941-e4fvj54l	74	15	necessary	necessary	JJ
cord-005941-e4fvj54l	74	16	for	for	IN
cord-005941-e4fvj54l	74	17	proper	proper	JJ
cord-005941-e4fvj54l	74	18	surfactant	surfactant	NN
cord-005941-e4fvj54l	74	19	function	function	NN
cord-005941-e4fvj54l	74	20	.	.	.
cord-005941-e4fvj54l	75	1	In	in	IN
cord-005941-e4fvj54l	75	2	1973	1973	CD
cord-005941-e4fvj54l	75	3	,	,	,
cord-005941-e4fvj54l	75	4	King	King	NNP
cord-005941-e4fvj54l	75	5	et	et	NNP
cord-005941-e4fvj54l	75	6	al	al	NNP
cord-005941-e4fvj54l	75	7	.	.	.
cord-005941-e4fvj54l	76	1	[	[	-LRB-
cord-005941-e4fvj54l	76	2	94	94	CD
cord-005941-e4fvj54l	76	3	]	]	-RRB-
cord-005941-e4fvj54l	76	4	could	could	MD
cord-005941-e4fvj54l	76	5	,	,	,
cord-005941-e4fvj54l	76	6	for	for	IN
cord-005941-e4fvj54l	76	7	the	the	DT
cord-005941-e4fvj54l	76	8	first	first	JJ
cord-005941-e4fvj54l	76	9	time	time	NN
cord-005941-e4fvj54l	76	10	,	,	,
cord-005941-e4fvj54l	76	11	demonstrate	demonstrate	VB
cord-005941-e4fvj54l	76	12	the	the	DT
cord-005941-e4fvj54l	76	13	existence	existence	NN
cord-005941-e4fvj54l	76	14	of	of	IN
cord-005941-e4fvj54l	76	15	specific	specific	JJ
cord-005941-e4fvj54l	76	16	surfactant	surfactant	NN
cord-005941-e4fvj54l	76	17	proteins	protein	NNS
cord-005941-e4fvj54l	76	18	.	.	.
cord-005941-e4fvj54l	77	1	By	by	IN
cord-005941-e4fvj54l	77	2	weight	weight	NN
cord-005941-e4fvj54l	77	3	,	,	,
cord-005941-e4fvj54l	77	4	protein	protein	NN
cord-005941-e4fvj54l	77	5	accounts	account	VBZ
cord-005941-e4fvj54l	77	6	for	for	IN
cord-005941-e4fvj54l	77	7	approximately	approximately	RB
cord-005941-e4fvj54l	77	8	10	10	CD
cord-005941-e4fvj54l	77	9	%	%	NN
cord-005941-e4fvj54l	77	10	of	of	IN
cord-005941-e4fvj54l	77	11	whole	whole	JJ
cord-005941-e4fvj54l	77	12	isolated	isolate	VBN
cord-005941-e4fvj54l	77	13	surfactant	surfactant	NN
cord-005941-e4fvj54l	77	14	.	.	.
cord-005941-e4fvj54l	78	1	About	about	RB
cord-005941-e4fvj54l	78	2	80	80	CD
cord-005941-e4fvj54l	78	3	%	%	NN
cord-005941-e4fvj54l	78	4	of	of	IN
cord-005941-e4fvj54l	78	5	this	this	DT
cord-005941-e4fvj54l	78	6	protein	protein	NN
cord-005941-e4fvj54l	78	7	portion	portion	NN
cord-005941-e4fvj54l	78	8	consists	consist	VBZ
cord-005941-e4fvj54l	78	9	of	of	IN
cord-005941-e4fvj54l	78	10	contaminating	contaminate	VBG
cord-005941-e4fvj54l	78	11	serum	serum	NN
cord-005941-e4fvj54l	78	12	proteins	protein	NNS
cord-005941-e4fvj54l	78	13	while	while	IN
cord-005941-e4fvj54l	78	14	only	only	RB
cord-005941-e4fvj54l	78	15	20	20	CD
cord-005941-e4fvj54l	78	16	%	%	NN
cord-005941-e4fvj54l	78	17	are	be	VBP
cord-005941-e4fvj54l	78	18	made	make	VBN
cord-005941-e4fvj54l	78	19	up	up	RP
cord-005941-e4fvj54l	78	20	by	by	IN
cord-005941-e4fvj54l	78	21	the	the	DT
cord-005941-e4fvj54l	78	22	surfactant	surfactant	NN
cord-005941-e4fvj54l	78	23	-	-	HYPH
cord-005941-e4fvj54l	78	24	specific	specific	JJ
cord-005941-e4fvj54l	78	25	proteins	protein	NNS
cord-005941-e4fvj54l	78	26	(	(	-LRB-
cord-005941-e4fvj54l	78	27	Fig	fig	NN
cord-005941-e4fvj54l	78	28	.	.	.
cord-005941-e4fvj54l	78	29	1	1	CD
cord-005941-e4fvj54l	78	30	)	)	-RRB-
cord-005941-e4fvj54l	78	31	.	.	.
cord-005941-e4fvj54l	79	1	Four	four	CD
cord-005941-e4fvj54l	79	2	surfactant	surfactant	NN
cord-005941-e4fvj54l	79	3	specific	specific	JJ
cord-005941-e4fvj54l	79	4	proteins	protein	NNS
cord-005941-e4fvj54l	79	5	(	(	-LRB-
cord-005941-e4fvj54l	79	6	SP	SP	NNP
cord-005941-e4fvj54l	79	7	)	)	-RRB-
cord-005941-e4fvj54l	79	8	have	have	VBP
cord-005941-e4fvj54l	79	9	so	so	RB
cord-005941-e4fvj54l	79	10	far	far	RB
cord-005941-e4fvj54l	79	11	been	be	VBN
cord-005941-e4fvj54l	79	12	identified	identify	VBN
cord-005941-e4fvj54l	79	13	(	(	-LRB-
cord-005941-e4fvj54l	79	14	Table	table	NN
cord-005941-e4fvj54l	79	15	1	1	CD
cord-005941-e4fvj54l	79	16	)	)	-RRB-
cord-005941-e4fvj54l	79	17	.	.	.
cord-005941-e4fvj54l	80	1	A	a	DT
cord-005941-e4fvj54l	80	2	simplified	simplified	JJ
cord-005941-e4fvj54l	80	3	nomenclature	nomenclature	NN
cord-005941-e4fvj54l	80	4	of	of	IN
cord-005941-e4fvj54l	80	5	these	these	DT
cord-005941-e4fvj54l	80	6	proteins	protein	NNS
cord-005941-e4fvj54l	80	7	has	have	VBZ
cord-005941-e4fvj54l	80	8	recently	recently	RB
cord-005941-e4fvj54l	80	9	been	be	VBN
cord-005941-e4fvj54l	80	10	proposed	propose	VBN
cord-005941-e4fvj54l	80	11	[	[	-LRB-
cord-005941-e4fvj54l	80	12	145	145	CD
cord-005941-e4fvj54l	80	13	]	]	-RRB-
cord-005941-e4fvj54l	80	14	and	and	CC
cord-005941-e4fvj54l	80	15	is	be	VBZ
cord-005941-e4fvj54l	80	16	increasingly	increasingly	RB
cord-005941-e4fvj54l	80	17	being	be	VBG
cord-005941-e4fvj54l	80	18	accepted	accept	VBN
cord-005941-e4fvj54l	80	19	,	,	,
cord-005941-e4fvj54l	80	20	despite	despite	IN
cord-005941-e4fvj54l	80	21	certain	certain	JJ
cord-005941-e4fvj54l	80	22	difficulties	difficulty	NNS
cord-005941-e4fvj54l	80	23	and	and	CC
cord-005941-e4fvj54l	80	24	disadvantages	disadvantage	NNS
cord-005941-e4fvj54l	80	25	[	[	-LRB-
cord-005941-e4fvj54l	80	26	33	33	CD
cord-005941-e4fvj54l	80	27	]	]	-RRB-
cord-005941-e4fvj54l	80	28	.	.	.
cord-005941-e4fvj54l	81	1	The	the	DT
cord-005941-e4fvj54l	81	2	first	first	JJ
cord-005941-e4fvj54l	81	3	three	three	CD
cord-005941-e4fvj54l	81	4	proteins	protein	NNS
cord-005941-e4fvj54l	81	5	are	be	VBP
cord-005941-e4fvj54l	81	6	simply	simply	RB
cord-005941-e4fvj54l	81	7	termed	term	VBN
cord-005941-e4fvj54l	81	8	surfactant	surfactant	NN
cord-005941-e4fvj54l	81	9	protein	protein	NN
cord-005941-e4fvj54l	81	10	A	A	NNP
cord-005941-e4fvj54l	81	11	,	,	,
cord-005941-e4fvj54l	81	12	B	b	NN
cord-005941-e4fvj54l	81	13	,	,	,
cord-005941-e4fvj54l	81	14	and	and	CC
cord-005941-e4fvj54l	81	15	C	c	NN
cord-005941-e4fvj54l	81	16	in	in	IN
cord-005941-e4fvj54l	81	17	descending	descend	VBG
cord-005941-e4fvj54l	81	18	rank	rank	NN
cord-005941-e4fvj54l	81	19	of	of	IN
cord-005941-e4fvj54l	81	20	their	-PRON-	PRP$
cord-005941-e4fvj54l	81	21	molecular	molecular	JJ
cord-005941-e4fvj54l	81	22	masses	masse	NNS
cord-005941-e4fvj54l	81	23	.	.	.
cord-005941-e4fvj54l	82	1	More	more	RBR
cord-005941-e4fvj54l	82	2	recently	recently	RB
cord-005941-e4fvj54l	82	3	,	,	,
cord-005941-e4fvj54l	82	4	a	a	DT
cord-005941-e4fvj54l	82	5	fourth	fourth	JJ
cord-005941-e4fvj54l	82	6	protein	protein	NN
cord-005941-e4fvj54l	82	7	called	call	VBN
cord-005941-e4fvj54l	82	8	SP	SP	NNP
cord-005941-e4fvj54l	82	9	-	-	HYPH
cord-005941-e4fvj54l	82	10	D	D	NNP
cord-005941-e4fvj54l	82	11	has	have	VBZ
cord-005941-e4fvj54l	82	12	been	be	VBN
cord-005941-e4fvj54l	82	13	described	describe	VBN
cord-005941-e4fvj54l	82	14	.	.	.
cord-005941-e4fvj54l	83	1	The	the	DT
cord-005941-e4fvj54l	83	2	primary	primary	JJ
cord-005941-e4fvj54l	83	3	structures	structure	NNS
cord-005941-e4fvj54l	83	4	of	of	IN
cord-005941-e4fvj54l	83	5	surfactant	surfactant	NN
cord-005941-e4fvj54l	83	6	proteins	protein	NNS
cord-005941-e4fvj54l	83	7	A	A	NNP
cord-005941-e4fvj54l	83	8	,	,	,
cord-005941-e4fvj54l	83	9	B	b	NN
cord-005941-e4fvj54l	83	10	,	,	,
cord-005941-e4fvj54l	83	11	and	and	CC
cord-005941-e4fvj54l	83	12	C	C	NNP
cord-005941-e4fvj54l	83	13	have	have	VBP
cord-005941-e4fvj54l	83	14	been	be	VBN
cord-005941-e4fvj54l	83	15	identified	identify	VBN
cord-005941-e4fvj54l	83	16	,	,	,
cord-005941-e4fvj54l	83	17	and	and	CC
cord-005941-e4fvj54l	83	18	their	-PRON-	PRP$
cord-005941-e4fvj54l	83	19	commercial	commercial	JJ
cord-005941-e4fvj54l	83	20	production	production	NN
cord-005941-e4fvj54l	83	21	by	by	IN
cord-005941-e4fvj54l	83	22	modern	modern	JJ
cord-005941-e4fvj54l	83	23	techniques	technique	NNS
cord-005941-e4fvj54l	83	24	of	of	IN
cord-005941-e4fvj54l	83	25	molecular	molecular	JJ
cord-005941-e4fvj54l	83	26	biology	biology	NN
cord-005941-e4fvj54l	83	27	is	be	VBZ
cord-005941-e4fvj54l	83	28	possible	possible	JJ
cord-005941-e4fvj54l	83	29	[	[	-LRB-
cord-005941-e4fvj54l	83	30	67	67	CD
cord-005941-e4fvj54l	83	31	,	,	,
cord-005941-e4fvj54l	83	32	158	158	CD
cord-005941-e4fvj54l	83	33	]	]	-RRB-
cord-005941-e4fvj54l	83	34	.	.	.
cord-005941-e4fvj54l	84	1	SP	SP	NNP
cord-005941-e4fvj54l	84	2	-	-	HYPH
cord-005941-e4fvj54l	84	3	A	A	NNP
cord-005941-e4fvj54l	84	4	is	be	VBZ
cord-005941-e4fvj54l	84	5	the	the	DT
cord-005941-e4fvj54l	84	6	major	major	JJ
cord-005941-e4fvj54l	84	7	surfactant	surfactant	NN
cord-005941-e4fvj54l	84	8	protein	protein	NN
cord-005941-e4fvj54l	84	9	in	in	IN
cord-005941-e4fvj54l	84	10	regard	regard	NN
cord-005941-e4fvj54l	84	11	to	to	IN
cord-005941-e4fvj54l	84	12	relative	relative	JJ
cord-005941-e4fvj54l	84	13	abundance	abundance	NN
cord-005941-e4fvj54l	84	14	as	as	RB
cord-005941-e4fvj54l	84	15	well	well	RB
cord-005941-e4fvj54l	84	16	as	as	IN
cord-005941-e4fvj54l	84	17	size	size	NN
cord-005941-e4fvj54l	84	18	.	.	.
cord-005941-e4fvj54l	85	1	In	in	IN
cord-005941-e4fvj54l	85	2	vivo	vivo	NN
cord-005941-e4fvj54l	85	3	,	,	,
cord-005941-e4fvj54l	85	4	SP	SP	NNP
cord-005941-e4fvj54l	85	5	-	-	HYPH
cord-005941-e4fvj54l	85	6	A	A	NNP
cord-005941-e4fvj54l	85	7	is	be	VBZ
cord-005941-e4fvj54l	85	8	found	find	VBN
cord-005941-e4fvj54l	85	9	as	as	IN
cord-005941-e4fvj54l	85	10	a	a	DT
cord-005941-e4fvj54l	85	11	group	group	NN
cord-005941-e4fvj54l	85	12	of	of	IN
cord-005941-e4fvj54l	85	13	isoforms	isoform	NNS
cord-005941-e4fvj54l	85	14	with	with	IN
cord-005941-e4fvj54l	85	15	a	a	DT
cord-005941-e4fvj54l	85	16	molecular	molecular	JJ
cord-005941-e4fvj54l	85	17	weight	weight	NN
cord-005941-e4fvj54l	85	18	ranging	range	VBG
cord-005941-e4fvj54l	85	19	from	from	IN
cord-005941-e4fvj54l	85	20	approximately	approximately	RB
cord-005941-e4fvj54l	85	21	28	28	CD
cord-005941-e4fvj54l	85	22	to	to	TO
cord-005941-e4fvj54l	85	23	36	36	CD
cord-005941-e4fvj54l	85	24	kDa	kDa	NNS
cord-005941-e4fvj54l	85	25	,	,	,
cord-005941-e4fvj54l	85	26	depending	depend	VBG
cord-005941-e4fvj54l	85	27	on	on	IN
cord-005941-e4fvj54l	85	28	the	the	DT
cord-005941-e4fvj54l	85	29	extent	extent	NN
cord-005941-e4fvj54l	85	30	of	of	IN
cord-005941-e4fvj54l	85	31	posttranslational	posttranslational	JJ
cord-005941-e4fvj54l	85	32	modifications	modification	NNS
cord-005941-e4fvj54l	85	33	[	[	-LRB-
cord-005941-e4fvj54l	85	34	67	67	CD
cord-005941-e4fvj54l	85	35	]	]	-RRB-
cord-005941-e4fvj54l	85	36	.	.	.
cord-005941-e4fvj54l	86	1	It	-PRON-	PRP
cord-005941-e4fvj54l	86	2	has	have	VBZ
cord-005941-e4fvj54l	86	3	structural	structural	JJ
cord-005941-e4fvj54l	86	4	homologies	homology	NNS
cord-005941-e4fvj54l	86	5	with	with	IN
cord-005941-e4fvj54l	86	6	Clq	Clq	NNP
cord-005941-e4fvj54l	86	7	,	,	,
cord-005941-e4fvj54l	86	8	a	a	DT
cord-005941-e4fvj54l	86	9	protein	protein	NN
cord-005941-e4fvj54l	86	10	of	of	IN
cord-005941-e4fvj54l	86	11	the	the	DT
cord-005941-e4fvj54l	86	12	classical	classical	JJ
cord-005941-e4fvj54l	86	13	complement	complement	NN
cord-005941-e4fvj54l	86	14	path	path	NN
cord-005941-e4fvj54l	86	15	-	-	HYPH
cord-005941-e4fvj54l	86	16	way	way	NN
cord-005941-e4fvj54l	86	17	[	[	-LRB-
cord-005941-e4fvj54l	86	18	171	171	CD
cord-005941-e4fvj54l	86	19	,	,	,
cord-005941-e4fvj54l	86	20	182	182	CD
cord-005941-e4fvj54l	86	21	]	]	-RRB-
cord-005941-e4fvj54l	86	22	,	,	,
cord-005941-e4fvj54l	86	23	and	and	CC
cord-005941-e4fvj54l	86	24	contains	contain	VBZ
cord-005941-e4fvj54l	86	25	a	a	DT
cord-005941-e4fvj54l	86	26	collagen	collagen	NN
cord-005941-e4fvj54l	86	27	-	-	HYPH
cord-005941-e4fvj54l	86	28	like	like	JJ
cord-005941-e4fvj54l	86	29	domain	domain	NN
cord-005941-e4fvj54l	86	30	[	[	-LRB-
cord-005941-e4fvj54l	86	31	28	28	CD
cord-005941-e4fvj54l	86	32	]	]	-RRB-
cord-005941-e4fvj54l	86	33	which	which	WDT
cord-005941-e4fvj54l	86	34	is	be	VBZ
cord-005941-e4fvj54l	86	35	the	the	DT
cord-005941-e4fvj54l	86	36	probable	probable	JJ
cord-005941-e4fvj54l	86	37	association	association	NN
cord-005941-e4fvj54l	86	38	site	site	NN
cord-005941-e4fvj54l	86	39	of	of	IN
cord-005941-e4fvj54l	86	40	SP	SP	NNP
cord-005941-e4fvj54l	86	41	-	-	HYPH
cord-005941-e4fvj54l	86	42	A	A	NNP
cord-005941-e4fvj54l	86	43	monomeres	monomere	NNS
cord-005941-e4fvj54l	86	44	.	.	.
cord-005941-e4fvj54l	87	1	After	after	IN
cord-005941-e4fvj54l	87	2	alveolar	alveolar	JJ
cord-005941-e4fvj54l	87	3	secretion	secretion	NN
cord-005941-e4fvj54l	87	4	,	,	,
cord-005941-e4fvj54l	87	5	SP	SP	NNP
cord-005941-e4fvj54l	87	6	-	-	HYPH
cord-005941-e4fvj54l	87	7	A	A	NNP
cord-005941-e4fvj54l	87	8	is	be	VBZ
cord-005941-e4fvj54l	87	9	predominantly	predominantly	RB
cord-005941-e4fvj54l	87	10	:	:	:
cord-005941-e4fvj54l	87	11	found	find	VBN
cord-005941-e4fvj54l	87	12	as	as	IN
cord-005941-e4fvj54l	87	13	a	a	DT
cord-005941-e4fvj54l	87	14	multimeric	multimeric	JJ
cord-005941-e4fvj54l	87	15	molecule	molecule	NN
cord-005941-e4fvj54l	87	16	resembling	resemble	VBG
cord-005941-e4fvj54l	87	17	a	a	DT
cord-005941-e4fvj54l	87	18	flower	flower	NN
cord-005941-e4fvj54l	87	19	bouquet	bouquet	NN
cord-005941-e4fvj54l	87	20	[	[	-LRB-
cord-005941-e4fvj54l	87	21	182	182	CD
cord-005941-e4fvj54l	87	22	]	]	-RRB-
cord-005941-e4fvj54l	87	23	.	.	.
cord-005941-e4fvj54l	88	1	Recent	recent	JJ
cord-005941-e4fvj54l	88	2	evidence	evidence	NN
cord-005941-e4fvj54l	88	3	suggests	suggest	VBZ
cord-005941-e4fvj54l	88	4	that	that	IN
cord-005941-e4fvj54l	88	5	in	in	IN
cord-005941-e4fvj54l	88	6	man	man	NN
cord-005941-e4fvj54l	88	7	,	,	,
cord-005941-e4fvj54l	88	8	there	there	EX
cord-005941-e4fvj54l	88	9	are	be	VBP
cord-005941-e4fvj54l	88	10	at	at	RB
cord-005941-e4fvj54l	88	11	least	least	RBS
cord-005941-e4fvj54l	88	12	two	two	CD
cord-005941-e4fvj54l	88	13	different	different	JJ
cord-005941-e4fvj54l	88	14	SP	SP	NNP
cord-005941-e4fvj54l	88	15	-	-	HYPH
cord-005941-e4fvj54l	88	16	A	A	NNP
cord-005941-e4fvj54l	88	17	subtypes	subtype	NNS
cord-005941-e4fvj54l	88	18	encoded	encode	VBN
cord-005941-e4fvj54l	88	19	on	on	IN
cord-005941-e4fvj54l	88	20	two	two	CD
cord-005941-e4fvj54l	88	21	separate	separate	JJ
cord-005941-e4fvj54l	88	22	genes	gene	NNS
cord-005941-e4fvj54l	88	23	[	[	-LRB-
cord-005941-e4fvj54l	88	24	44	44	CD
cord-005941-e4fvj54l	88	25	,	,	,
cord-005941-e4fvj54l	88	26	188	188	CD
cord-005941-e4fvj54l	88	27	]	]	-RRB-
cord-005941-e4fvj54l	88	28	.	.	.
cord-005941-e4fvj54l	89	1	This	this	DT
cord-005941-e4fvj54l	89	2	may	may	MD
cord-005941-e4fvj54l	89	3	have	have	VB
cord-005941-e4fvj54l	89	4	structural	structural	JJ
cord-005941-e4fvj54l	89	5	implications	implication	NNS
cord-005941-e4fvj54l	89	6	for	for	IN
cord-005941-e4fvj54l	89	7	the	the	DT
cord-005941-e4fvj54l	89	8	arrangement	arrangement	NN
cord-005941-e4fvj54l	89	9	of	of	IN
cord-005941-e4fvj54l	89	10	the	the	DT
cord-005941-e4fvj54l	89	11	naturally	naturally	RB
cord-005941-e4fvj54l	89	12	occurring	occur	VBG
cord-005941-e4fvj54l	89	13	SP	SP	NNP
cord-005941-e4fvj54l	89	14	-	-	HYPH
cord-005941-e4fvj54l	89	15	A	A	NNP
cord-005941-e4fvj54l	89	16	multimeres	multimere	NNS
cord-005941-e4fvj54l	89	17	[	[	-LRB-
cord-005941-e4fvj54l	89	18	183	183	CD
cord-005941-e4fvj54l	89	19	]	]	-RRB-
cord-005941-e4fvj54l	89	20	,	,	,
cord-005941-e4fvj54l	89	21	but	but	CC
cord-005941-e4fvj54l	89	22	the	the	DT
cord-005941-e4fvj54l	89	23	functional	functional	JJ
cord-005941-e4fvj54l	89	24	significance	significance	NN
cord-005941-e4fvj54l	89	25	of	of	IN
cord-005941-e4fvj54l	89	26	these	these	DT
cord-005941-e4fvj54l	89	27	findings	finding	NNS
cord-005941-e4fvj54l	89	28	awaits	await	VBZ
cord-005941-e4fvj54l	89	29	further	further	JJ
cord-005941-e4fvj54l	89	30	clarification	clarification	NN
cord-005941-e4fvj54l	89	31	.	.	.
cord-005941-e4fvj54l	90	1	SP	SP	NNP
cord-005941-e4fvj54l	90	2	-	-	HYPH
cord-005941-e4fvj54l	90	3	A	A	NNP
cord-005941-e4fvj54l	90	4	seems	seem	VBZ
cord-005941-e4fvj54l	90	5	to	to	TO
cord-005941-e4fvj54l	90	6	play	play	VB
cord-005941-e4fvj54l	90	7	an	an	DT
cord-005941-e4fvj54l	90	8	important	important	JJ
cord-005941-e4fvj54l	90	9	role	role	NN
cord-005941-e4fvj54l	90	10	in	in	IN
cord-005941-e4fvj54l	90	11	the	the	DT
cord-005941-e4fvj54l	90	12	formation	formation	NN
cord-005941-e4fvj54l	90	13	of	of	IN
cord-005941-e4fvj54l	90	14	a	a	DT
cord-005941-e4fvj54l	90	15	preliminary	preliminary	JJ
cord-005941-e4fvj54l	90	16	alveolar	alveolar	NN
cord-005941-e4fvj54l	90	17	surfactant	surfactant	NN
cord-005941-e4fvj54l	90	18	layer	layer	NN
cord-005941-e4fvj54l	90	19	called	call	VBN
cord-005941-e4fvj54l	90	20	tubular	tubular	JJ
cord-005941-e4fvj54l	90	21	myelin	myelin	NN
cord-005941-e4fvj54l	90	22	which	which	WDT
cord-005941-e4fvj54l	90	23	is	be	VBZ
cord-005941-e4fvj54l	90	24	found	find	VBN
cord-005941-e4fvj54l	90	25	immediately	immediately	RB
cord-005941-e4fvj54l	90	26	after	after	IN
cord-005941-e4fvj54l	90	27	alveolar	alveolar	JJ
cord-005941-e4fvj54l	90	28	secretion	secretion	NN
cord-005941-e4fvj54l	90	29	[	[	-LRB-
cord-005941-e4fvj54l	90	30	145	145	CD
cord-005941-e4fvj54l	90	31	,	,	,
cord-005941-e4fvj54l	90	32	181	181	CD
cord-005941-e4fvj54l	90	33	,	,	,
cord-005941-e4fvj54l	90	34	191	191	CD
cord-005941-e4fvj54l	90	35	]	]	-RRB-
cord-005941-e4fvj54l	90	36	.	.	.
cord-005941-e4fvj54l	91	1	In	in	IN
cord-005941-e4fvj54l	91	2	concert	concert	NN
cord-005941-e4fvj54l	91	3	with	with	IN
cord-005941-e4fvj54l	91	4	SP	SP	NNP
cord-005941-e4fvj54l	91	5	-	-	HYPH
cord-005941-e4fvj54l	91	6	B	B	NNP
cord-005941-e4fvj54l	91	7	and	and	CC
cord-005941-e4fvj54l	91	8	SP	SP	NNP
cord-005941-e4fvj54l	91	9	-	-	HYPH
cord-005941-e4fvj54l	91	10	C	C	NNP
cord-005941-e4fvj54l	91	11	,	,	,
cord-005941-e4fvj54l	91	12	SP	SP	NNP
cord-005941-e4fvj54l	91	13	-	-	:
cord-005941-e4fvj54l	91	14	A	A	NNP
cord-005941-e4fvj54l	91	15	probably	probably	RB
cord-005941-e4fvj54l	91	16	enhances	enhance	VBZ
cord-005941-e4fvj54l	91	17	the	the	DT
cord-005941-e4fvj54l	91	18	surface	surface	NN
cord-005941-e4fvj54l	91	19	activity	activity	NN
cord-005941-e4fvj54l	91	20	of	of	IN
cord-005941-e4fvj54l	91	21	the	the	DT
cord-005941-e4fvj54l	91	22	surfactant	surfactant	NN
cord-005941-e4fvj54l	91	23	monolayer	monolayer	NN
cord-005941-e4fvj54l	91	24	[	[	-LRB-
cord-005941-e4fvj54l	91	25	43	43	CD
cord-005941-e4fvj54l	91	26	]	]	-RRB-
cord-005941-e4fvj54l	91	27	.	.	.
cord-005941-e4fvj54l	92	1	However	however	RB
cord-005941-e4fvj54l	92	2	,	,	,
cord-005941-e4fvj54l	92	3	the	the	DT
cord-005941-e4fvj54l	92	4	importance	importance	NN
cord-005941-e4fvj54l	92	5	of	of	IN
cord-005941-e4fvj54l	92	6	the	the	DT
cord-005941-e4fvj54l	92	7	presence	presence	NN
cord-005941-e4fvj54l	92	8	of	of	IN
cord-005941-e4fvj54l	92	9	SP	SP	NNP
cord-005941-e4fvj54l	92	10	-	-	HYPH
cord-005941-e4fvj54l	92	11	A	A	NNP
cord-005941-e4fvj54l	92	12	regarding	regard	VBG
cord-005941-e4fvj54l	92	13	this	this	DT
cord-005941-e4fvj54l	92	14	aspect	aspect	NN
cord-005941-e4fvj54l	92	15	of	of	IN
cord-005941-e4fvj54l	92	16	surfactant	surfactant	NN
cord-005941-e4fvj54l	92	17	function	function	NN
cord-005941-e4fvj54l	92	18	is	be	VBZ
cord-005941-e4fvj54l	92	19	still	still	RB
cord-005941-e4fvj54l	92	20	debated	debate	VBN
cord-005941-e4fvj54l	92	21	[	[	-LRB-
cord-005941-e4fvj54l	92	22	146	146	CD
cord-005941-e4fvj54l	92	23	]	]	-RRB-
cord-005941-e4fvj54l	92	24	.	.	.
cord-005941-e4fvj54l	93	1	SP	SP	NNP
cord-005941-e4fvj54l	93	2	-	-	HYPH
cord-005941-e4fvj54l	93	3	A	A	NNP
cord-005941-e4fvj54l	93	4	seems	seem	VBZ
cord-005941-e4fvj54l	93	5	to	to	TO
cord-005941-e4fvj54l	93	6	be	be	VB
cord-005941-e4fvj54l	93	7	unique	unique	JJ
cord-005941-e4fvj54l	93	8	among	among	IN
cord-005941-e4fvj54l	93	9	the	the	DT
cord-005941-e4fvj54l	93	10	surfactant	surfactant	NN
cord-005941-e4fvj54l	93	11	specific	specific	JJ
cord-005941-e4fvj54l	93	12	proteins	protein	NNS
cord-005941-e4fvj54l	93	13	as	as	IN
cord-005941-e4fvj54l	93	14	it	-PRON-	PRP
cord-005941-e4fvj54l	93	15	apparently	apparently	RB
cord-005941-e4fvj54l	93	16	has	have	VBZ
cord-005941-e4fvj54l	93	17	additional	additional	JJ
cord-005941-e4fvj54l	93	18	functions	function	NNS
cord-005941-e4fvj54l	93	19	in	in	IN
cord-005941-e4fvj54l	93	20	the	the	DT
cord-005941-e4fvj54l	93	21	surfactant	surfactant	NN
cord-005941-e4fvj54l	93	22	complex	complex	NN
cord-005941-e4fvj54l	93	23	apart	apart	RB
cord-005941-e4fvj54l	93	24	from	from	IN
cord-005941-e4fvj54l	93	25	influencing	influence	VBG
cord-005941-e4fvj54l	93	26	surface	surface	NN
cord-005941-e4fvj54l	93	27	activity	activity	NN
cord-005941-e4fvj54l	93	28	.	.	.
cord-005941-e4fvj54l	94	1	The	the	DT
cord-005941-e4fvj54l	94	2	structural	structural	JJ
cord-005941-e4fvj54l	94	3	homologies	homology	NNS
cord-005941-e4fvj54l	94	4	to	to	IN
cord-005941-e4fvj54l	94	5	the	the	DT
cord-005941-e4fvj54l	94	6	complement	complement	NN
cord-005941-e4fvj54l	95	1	protein	protein	NN
cord-005941-e4fvj54l	95	2	Clq	Clq	NNP
cord-005941-e4fvj54l	95	3	stimulated	stimulate	VBD
cord-005941-e4fvj54l	95	4	investigations	investigation	NNS
cord-005941-e4fvj54l	95	5	of	of	IN
cord-005941-e4fvj54l	95	6	possible	possible	JJ
cord-005941-e4fvj54l	95	7	common	common	JJ
cord-005941-e4fvj54l	95	8	biological	biological	JJ
cord-005941-e4fvj54l	95	9	functions	function	NNS
cord-005941-e4fvj54l	95	10	of	of	IN
cord-005941-e4fvj54l	95	11	these	these	DT
cord-005941-e4fvj54l	95	12	two	two	CD
cord-005941-e4fvj54l	95	13	proteins	protein	NNS
cord-005941-e4fvj54l	95	14	.	.	.
cord-005941-e4fvj54l	96	1	Indeed	indeed	RB
cord-005941-e4fvj54l	96	2	,	,	,
cord-005941-e4fvj54l	96	3	it	-PRON-	PRP
cord-005941-e4fvj54l	96	4	was	be	VBD
cord-005941-e4fvj54l	96	5	found	find	VBN
cord-005941-e4fvj54l	96	6	that	that	IN
cord-005941-e4fvj54l	96	7	the	the	DT
cord-005941-e4fvj54l	96	8	presence	presence	NN
cord-005941-e4fvj54l	96	9	of	of	IN
cord-005941-e4fvj54l	96	10	SP	SP	NNP
cord-005941-e4fvj54l	96	11	-	-	HYPH
cord-005941-e4fvj54l	96	12	A	A	NNP
cord-005941-e4fvj54l	96	13	enhances	enhance	VBZ
cord-005941-e4fvj54l	96	14	the	the	DT
cord-005941-e4fvj54l	96	15	phagocytosis	phagocytosis	NN
cord-005941-e4fvj54l	96	16	of	of	IN
cord-005941-e4fvj54l	96	17	opsonized	opsonize	VBN
cord-005941-e4fvj54l	96	18	sheep	sheep	NN
cord-005941-e4fvj54l	96	19	erythrocytes	erythrocyte	NNS
cord-005941-e4fvj54l	96	20	by	by	IN
cord-005941-e4fvj54l	96	21	macrophages	macrophage	NNS
cord-005941-e4fvj54l	96	22	and	and	CC
cord-005941-e4fvj54l	96	23	monocytes	monocyte	NNS
cord-005941-e4fvj54l	96	24	in	in	IN
cord-005941-e4fvj54l	96	25	a	a	DT
cord-005941-e4fvj54l	96	26	concentration	concentration	NN
cord-005941-e4fvj54l	96	27	-	-	HYPH
cord-005941-e4fvj54l	96	28	dependent	dependent	JJ
cord-005941-e4fvj54l	96	29	manner	manner	NN
cord-005941-e4fvj54l	96	30	[	[	-LRB-
cord-005941-e4fvj54l	96	31	171	171	CD
cord-005941-e4fvj54l	96	32	]	]	-RRB-
cord-005941-e4fvj54l	96	33	.	.	.
cord-005941-e4fvj54l	97	1	Furthermore	furthermore	RB
cord-005941-e4fvj54l	97	2	,	,	,
cord-005941-e4fvj54l	97	3	SP	SP	NNP
cord-005941-e4fvj54l	97	4	-	-	HYPH
cord-005941-e4fvj54l	97	5	A	A	NNP
cord-005941-e4fvj54l	97	6	is	be	VBZ
cord-005941-e4fvj54l	97	7	able	able	JJ
cord-005941-e4fvj54l	97	8	to	to	TO
cord-005941-e4fvj54l	97	9	increase	increase	VB
cord-005941-e4fvj54l	97	10	the	the	DT
cord-005941-e4fvj54l	97	11	phagocytosis	phagocytosis	NN
cord-005941-e4fvj54l	97	12	of	of	IN
cord-005941-e4fvj54l	97	13	Staphyloccocus	Staphyloccocus	NNP
cord-005941-e4fvj54l	97	14	aureus	aureus	NN
cord-005941-e4fvj54l	97	15	[	[	-LRB-
cord-005941-e4fvj54l	97	16	178	178	CD
cord-005941-e4fvj54l	97	17	]	]	-RRB-
cord-005941-e4fvj54l	97	18	,	,	,
cord-005941-e4fvj54l	97	19	herpes	herpes	NN
cord-005941-e4fvj54l	97	20	simplex	simplex	NNP
cord-005941-e4fvj54l	97	21	virus	virus	NN
cord-005941-e4fvj54l	97	22	type	type	NN
cord-005941-e4fvj54l	97	23	1	1	CD
cord-005941-e4fvj54l	97	24	[	[	-LRB-
cord-005941-e4fvj54l	97	25	178	178	CD
cord-005941-e4fvj54l	97	26	]	]	-RRB-
cord-005941-e4fvj54l	97	27	,	,	,
cord-005941-e4fvj54l	97	28	and	and	CC
cord-005941-e4fvj54l	97	29	colloidal	colloidal	NN
cord-005941-e4fvj54l	97	30	gold	gold	NN
cord-005941-e4fvj54l	97	31	particles	particle	NNS
cord-005941-e4fvj54l	97	32	[	[	-LRB-
cord-005941-e4fvj54l	97	33	43	43	CD
cord-005941-e4fvj54l	97	34	]	]	-RRB-
cord-005941-e4fvj54l	97	35	.	.	.
cord-005941-e4fvj54l	98	1	Thus	thus	RB
cord-005941-e4fvj54l	98	2	,	,	,
cord-005941-e4fvj54l	98	3	SP	SP	NNP
cord-005941-e4fvj54l	98	4	-	-	HYPH
cord-005941-e4fvj54l	98	5	A	A	NNP
cord-005941-e4fvj54l	98	6	seems	seem	VBZ
cord-005941-e4fvj54l	98	7	to	to	TO
cord-005941-e4fvj54l	98	8	play	play	VB
cord-005941-e4fvj54l	98	9	an	an	DT
cord-005941-e4fvj54l	98	10	important	important	JJ
cord-005941-e4fvj54l	98	11	role	role	NN
cord-005941-e4fvj54l	98	12	in	in	IN
cord-005941-e4fvj54l	98	13	the	the	DT
cord-005941-e4fvj54l	98	14	local	local	JJ
cord-005941-e4fvj54l	98	15	host	host	NN
cord-005941-e4fvj54l	98	16	defense	defense	NN
cord-005941-e4fvj54l	98	17	mechanisms	mechanism	NNS
cord-005941-e4fvj54l	98	18	of	of	IN
cord-005941-e4fvj54l	98	19	the	the	DT
cord-005941-e4fvj54l	98	20	lung	lung	NN
cord-005941-e4fvj54l	98	21	.	.	.
cord-005941-e4fvj54l	99	1	Another	another	DT
cord-005941-e4fvj54l	99	2	probable	probable	JJ
cord-005941-e4fvj54l	99	3	function	function	NN
cord-005941-e4fvj54l	99	4	of	of	IN
cord-005941-e4fvj54l	99	5	SP	SP	NNP
cord-005941-e4fvj54l	99	6	-	-	HYPH
cord-005941-e4fvj54l	99	7	A	A	NNP
cord-005941-e4fvj54l	99	8	is	be	VBZ
cord-005941-e4fvj54l	99	9	its	-PRON-	PRP$
cord-005941-e4fvj54l	99	10	ability	ability	NN
cord-005941-e4fvj54l	99	11	to	to	TO
cord-005941-e4fvj54l	99	12	regulate	regulate	VB
cord-005941-e4fvj54l	99	13	the	the	DT
cord-005941-e4fvj54l	99	14	alveolar	alveolar	NN
cord-005941-e4fvj54l	99	15	surfactant	surfactant	NN
cord-005941-e4fvj54l	99	16	concentration	concentration	NN
cord-005941-e4fvj54l	99	17	.	.	.
cord-005941-e4fvj54l	100	1	In	in	IN
cord-005941-e4fvj54l	100	2	vitro	vitro	FW
cord-005941-e4fvj54l	100	3	,	,	,
cord-005941-e4fvj54l	100	4	SP	SP	NNP
cord-005941-e4fvj54l	100	5	-	-	HYPH
cord-005941-e4fvj54l	100	6	A	A	NNP
cord-005941-e4fvj54l	100	7	inhibits	inhibit	VBZ
cord-005941-e4fvj54l	100	8	the	the	DT
cord-005941-e4fvj54l	100	9	secretion	secretion	NN
cord-005941-e4fvj54l	100	10	of	of	IN
cord-005941-e4fvj54l	100	11	phosphatidylcholine	phosphatidylcholine	NN
cord-005941-e4fvj54l	100	12	from	from	IN
cord-005941-e4fvj54l	100	13	cultured	cultured	JJ
cord-005941-e4fvj54l	100	14	alveolar	alveolar	NN
cord-005941-e4fvj54l	100	15	type	type	NN
cord-005941-e4fvj54l	100	16	II	ii	CD
cord-005941-e4fvj54l	100	17	cells	cell	NNS
cord-005941-e4fvj54l	100	18	[	[	-LRB-
cord-005941-e4fvj54l	100	19	34	34	CD
cord-005941-e4fvj54l	100	20	]	]	-RRB-
cord-005941-e4fvj54l	100	21	and	and	CC
cord-005941-e4fvj54l	100	22	enhances	enhance	VBZ
cord-005941-e4fvj54l	100	23	the	the	DT
cord-005941-e4fvj54l	100	24	uptake	uptake	NN
cord-005941-e4fvj54l	100	25	of	of	IN
cord-005941-e4fvj54l	100	26	surfactant	surfactant	NN
cord-005941-e4fvj54l	100	27	lipids	lipid	NNS
cord-005941-e4fvj54l	100	28	[	[	-LRB-
cord-005941-e4fvj54l	100	29	198	198	CD
cord-005941-e4fvj54l	100	30	]	]	-RRB-
cord-005941-e4fvj54l	100	31	.	.	.
cord-005941-e4fvj54l	101	1	Possibly	possibly	RB
cord-005941-e4fvj54l	101	2	,	,	,
cord-005941-e4fvj54l	101	3	these	these	DT
cord-005941-e4fvj54l	101	4	SP	SP	NNP
cord-005941-e4fvj54l	101	5	-	-	HYPH
cord-005941-e4fvj54l	101	6	A	a	DT
cord-005941-e4fvj54l	101	7	effects	effect	NNS
cord-005941-e4fvj54l	101	8	are	be	VBP
cord-005941-e4fvj54l	101	9	mediated	mediate	VBN
cord-005941-e4fvj54l	101	10	by	by	IN
cord-005941-e4fvj54l	101	11	an	an	DT
cord-005941-e4fvj54l	101	12	alveolar	alveolar	JJ
cord-005941-e4fvj54l	101	13	type	type	NN
cord-005941-e4fvj54l	101	14	II	II	NNP
cord-005941-e4fvj54l	101	15	cell	cell	NN
cord-005941-e4fvj54l	101	16	receptor	receptor	NN
cord-005941-e4fvj54l	101	17	[	[	-LRB-
cord-005941-e4fvj54l	101	18	157	157	CD
cord-005941-e4fvj54l	101	19	]	]	-RRB-
cord-005941-e4fvj54l	101	20	.	.	.
cord-005941-e4fvj54l	102	1	SP	SP	NNP
cord-005941-e4fvj54l	102	2	-	-	HYPH
cord-005941-e4fvj54l	102	3	B	B	NNP
cord-005941-e4fvj54l	102	4	is	be	VBZ
cord-005941-e4fvj54l	102	5	a	a	DT
cord-005941-e4fvj54l	102	6	small	small	JJ
cord-005941-e4fvj54l	102	7	protein	protein	NN
cord-005941-e4fvj54l	102	8	of	of	IN
cord-005941-e4fvj54l	102	9	a	a	DT
cord-005941-e4fvj54l	102	10	molecular	molecular	JJ
cord-005941-e4fvj54l	102	11	weight	weight	NN
cord-005941-e4fvj54l	102	12	of	of	IN
cord-005941-e4fvj54l	102	13	approximately	approximately	RB
cord-005941-e4fvj54l	102	14	8	8	CD
cord-005941-e4fvj54l	102	15	kDa	kDa	NNS
cord-005941-e4fvj54l	102	16	under	under	IN
cord-005941-e4fvj54l	102	17	reducing	reduce	VBG
cord-005941-e4fvj54l	102	18	conditions	condition	NNS
cord-005941-e4fvj54l	102	19	[	[	-LRB-
cord-005941-e4fvj54l	102	20	186	186	CD
cord-005941-e4fvj54l	102	21	]	]	-RRB-
cord-005941-e4fvj54l	102	22	.	.	.
cord-005941-e4fvj54l	103	1	Although	although	IN
cord-005941-e4fvj54l	103	2	it	-PRON-	PRP
cord-005941-e4fvj54l	103	3	is	be	VBZ
cord-005941-e4fvj54l	103	4	very	very	RB
cord-005941-e4fvj54l	103	5	hydrophobic	hydrophobic	JJ
cord-005941-e4fvj54l	103	6	,	,	,
cord-005941-e4fvj54l	103	7	it	-PRON-	PRP
cord-005941-e4fvj54l	103	8	remains	remain	VBZ
cord-005941-e4fvj54l	103	9	soluble	soluble	JJ
cord-005941-e4fvj54l	103	10	in	in	IN
cord-005941-e4fvj54l	103	11	aqueous	aqueous	JJ
cord-005941-e4fvj54l	103	12	solutions	solution	NNS
cord-005941-e4fvj54l	103	13	to	to	IN
cord-005941-e4fvj54l	103	14	some	some	DT
cord-005941-e4fvj54l	103	15	extent	extent	NN
cord-005941-e4fvj54l	103	16	.	.	.
cord-005941-e4fvj54l	104	1	SP	SP	NNP
cord-005941-e4fvj54l	104	2	-	-	HYPH
cord-005941-e4fvj54l	104	3	B	b	NN
cord-005941-e4fvj54l	104	4	forms	form	VBZ
cord-005941-e4fvj54l	104	5	thiol	thiol	NN
cord-005941-e4fvj54l	104	6	-	-	HYPH
cord-005941-e4fvj54l	104	7	dependent	dependent	JJ
cord-005941-e4fvj54l	104	8	oligomers	oligomer	NNS
cord-005941-e4fvj54l	104	9	of	of	IN
cord-005941-e4fvj54l	104	10	different	different	JJ
cord-005941-e4fvj54l	104	11	sizes	size	NNS
cord-005941-e4fvj54l	104	12	with	with	IN
cord-005941-e4fvj54l	104	13	the	the	DT
cord-005941-e4fvj54l	104	14	dimer	dimer	NN
cord-005941-e4fvj54l	104	15	probably	probably	RB
cord-005941-e4fvj54l	104	16	being	be	VBG
cord-005941-e4fvj54l	104	17	the	the	DT
cord-005941-e4fvj54l	104	18	most	most	RBS
cord-005941-e4fvj54l	104	19	common	common	JJ
cord-005941-e4fvj54l	104	20	form	form	NN
cord-005941-e4fvj54l	104	21	in	in	IN
cord-005941-e4fvj54l	104	22	vivo	vivo	NNP
cord-005941-e4fvj54l	104	23	[	[	-LRB-
cord-005941-e4fvj54l	104	24	84	84	CD
cord-005941-e4fvj54l	104	25	,	,	,
cord-005941-e4fvj54l	104	26	185	185	CD
cord-005941-e4fvj54l	104	27	]	]	-RRB-
cord-005941-e4fvj54l	104	28	.	.	.
cord-005941-e4fvj54l	105	1	It	-PRON-	PRP
cord-005941-e4fvj54l	105	2	has	have	VBZ
cord-005941-e4fvj54l	105	3	no	no	DT
cord-005941-e4fvj54l	105	4	known	know	VBN
cord-005941-e4fvj54l	105	5	immunomodulatory	immunomodulatory	JJ
cord-005941-e4fvj54l	105	6	or	or	CC
cord-005941-e4fvj54l	105	7	regulatory	regulatory	JJ
cord-005941-e4fvj54l	105	8	function	function	NN
cord-005941-e4fvj54l	105	9	but	but	CC
cord-005941-e4fvj54l	105	10	seems	seem	VBZ
cord-005941-e4fvj54l	105	11	to	to	TO
cord-005941-e4fvj54l	105	12	be	be	VB
cord-005941-e4fvj54l	105	13	a	a	DT
cord-005941-e4fvj54l	105	14	key	key	JJ
cord-005941-e4fvj54l	105	15	protein	protein	NN
cord-005941-e4fvj54l	105	16	in	in	IN
cord-005941-e4fvj54l	105	17	the	the	DT
cord-005941-e4fvj54l	105	18	formation	formation	NN
cord-005941-e4fvj54l	105	19	of	of	IN
cord-005941-e4fvj54l	105	20	a	a	DT
cord-005941-e4fvj54l	105	21	functionally	functionally	RB
cord-005941-e4fvj54l	105	22	optimal	optimal	JJ
cord-005941-e4fvj54l	105	23	and	and	CC
cord-005941-e4fvj54l	105	24	stable	stable	JJ
cord-005941-e4fvj54l	105	25	surfactant	surfactant	NN
cord-005941-e4fvj54l	105	26	monolayer	monolayer	NN
cord-005941-e4fvj54l	105	27	on	on	IN
cord-005941-e4fvj54l	105	28	the	the	DT
cord-005941-e4fvj54l	105	29	alveolar	alveolar	NN
cord-005941-e4fvj54l	105	30	surface	surface	NN
cord-005941-e4fvj54l	105	31	[	[	-LRB-
cord-005941-e4fvj54l	105	32	5	5	CD
cord-005941-e4fvj54l	105	33	,	,	,
cord-005941-e4fvj54l	105	34	23	23	CD
cord-005941-e4fvj54l	105	35	,	,	,
cord-005941-e4fvj54l	105	36	169	169	CD
cord-005941-e4fvj54l	105	37	]	]	-RRB-
cord-005941-e4fvj54l	105	38	.	.	.
cord-005941-e4fvj54l	106	1	Also	also	RB
cord-005941-e4fvj54l	106	2	,	,	,
cord-005941-e4fvj54l	106	3	SP	SP	NNP
cord-005941-e4fvj54l	106	4	-	-	HYPH
cord-005941-e4fvj54l	106	5	B	B	NNP
cord-005941-e4fvj54l	106	6	seems	seem	VBZ
cord-005941-e4fvj54l	106	7	to	to	TO
cord-005941-e4fvj54l	106	8	play	play	VB
cord-005941-e4fvj54l	106	9	a	a	DT
cord-005941-e4fvj54l	106	10	role	role	NN
cord-005941-e4fvj54l	106	11	in	in	IN
cord-005941-e4fvj54l	106	12	the	the	DT
cord-005941-e4fvj54l	106	13	formation	formation	NN
cord-005941-e4fvj54l	106	14	of	of	IN
cord-005941-e4fvj54l	106	15	tubular	tubular	JJ
cord-005941-e4fvj54l	106	16	myelin	myelin	NN
cord-005941-e4fvj54l	106	17	in	in	IN
cord-005941-e4fvj54l	106	18	cooperation	cooperation	NN
cord-005941-e4fvj54l	106	19	with	with	IN
cord-005941-e4fvj54l	106	20	SP	SP	NNP
cord-005941-e4fvj54l	106	21	-	-	HYPH
cord-005941-e4fvj54l	106	22	A	A	NNP
cord-005941-e4fvj54l	106	23	[	[	-LRB-
cord-005941-e4fvj54l	106	24	191	191	CD
cord-005941-e4fvj54l	106	25	]	]	-RRB-
cord-005941-e4fvj54l	106	26	.	.	.
cord-005941-e4fvj54l	107	1	Its	-PRON-	PRP$
cord-005941-e4fvj54l	107	2	amino	amino	NN
cord-005941-e4fvj54l	107	3	acid	acid	NN
cord-005941-e4fvj54l	107	4	sequence	sequence	NN
cord-005941-e4fvj54l	107	5	contains	contain	VBZ
cord-005941-e4fvj54l	107	6	high	high	JJ
cord-005941-e4fvj54l	107	7	amounts	amount	NNS
cord-005941-e4fvj54l	107	8	of	of	IN
cord-005941-e4fvj54l	107	9	cysteine	cysteine	NN
cord-005941-e4fvj54l	107	10	,	,	,
cord-005941-e4fvj54l	107	11	suggesting	suggest	VBG
cord-005941-e4fvj54l	107	12	that	that	IN
cord-005941-e4fvj54l	107	13	disulfide	disulfide	NN
cord-005941-e4fvj54l	107	14	bridges	bridge	NNS
cord-005941-e4fvj54l	107	15	may	may	MD
cord-005941-e4fvj54l	107	16	be	be	VB
cord-005941-e4fvj54l	107	17	important	important	JJ
cord-005941-e4fvj54l	107	18	to	to	IN
cord-005941-e4fvj54l	107	19	the	the	DT
cord-005941-e4fvj54l	107	20	role	role	NN
cord-005941-e4fvj54l	107	21	of	of	IN
cord-005941-e4fvj54l	107	22	this	this	DT
cord-005941-e4fvj54l	107	23	protein	protein	NN
cord-005941-e4fvj54l	107	24	in	in	IN
cord-005941-e4fvj54l	107	25	the	the	DT
cord-005941-e4fvj54l	107	26	surfactant	surfactant	NN
cord-005941-e4fvj54l	107	27	complex	complex	NN
cord-005941-e4fvj54l	107	28	[	[	-LRB-
cord-005941-e4fvj54l	107	29	67	67	CD
cord-005941-e4fvj54l	107	30	]	]	-RRB-
cord-005941-e4fvj54l	107	31	.	.	.
cord-005941-e4fvj54l	108	1	Indeed	indeed	RB
cord-005941-e4fvj54l	108	2	,	,	,
cord-005941-e4fvj54l	108	3	intramolecular	intramolecular	JJ
cord-005941-e4fvj54l	108	4	disulfide	disulfide	NN
cord-005941-e4fvj54l	108	5	bridges	bridge	NNS
cord-005941-e4fvj54l	108	6	seem	seem	VBP
cord-005941-e4fvj54l	108	7	to	to	TO
cord-005941-e4fvj54l	108	8	contribute	contribute	VB
cord-005941-e4fvj54l	108	9	to	to	IN
cord-005941-e4fvj54l	108	10	the	the	DT
cord-005941-e4fvj54l	108	11	structural	structural	JJ
cord-005941-e4fvj54l	108	12	properties	property	NNS
cord-005941-e4fvj54l	108	13	of	of	IN
cord-005941-e4fvj54l	108	14	the	the	DT
cord-005941-e4fvj54l	108	15	SP	SP	NNP
cord-005941-e4fvj54l	108	16	-	-	HYPH
cord-005941-e4fvj54l	108	17	B	B	NNP
cord-005941-e4fvj54l	108	18	polypeptide	polypeptide	NN
cord-005941-e4fvj54l	108	19	chain	chain	NN
cord-005941-e4fvj54l	108	20	,	,	,
cord-005941-e4fvj54l	108	21	and	and	CC
cord-005941-e4fvj54l	108	22	an	an	DT
cord-005941-e4fvj54l	108	23	intermolecular	intermolecular	JJ
cord-005941-e4fvj54l	108	24	disulfide	disulfide	NN
cord-005941-e4fvj54l	108	25	link	link	NN
cord-005941-e4fvj54l	108	26	may	may	MD
cord-005941-e4fvj54l	108	27	explain	explain	VB
cord-005941-e4fvj54l	108	28	the	the	DT
cord-005941-e4fvj54l	108	29	frequent	frequent	JJ
cord-005941-e4fvj54l	108	30	natural	natural	JJ
cord-005941-e4fvj54l	108	31	occurrence	occurrence	NN
cord-005941-e4fvj54l	108	32	of	of	IN
cord-005941-e4fvj54l	108	33	SP	SP	NNP
cord-005941-e4fvj54l	108	34	-	-	HYPH
cord-005941-e4fvj54l	108	35	B	b	NN
cord-005941-e4fvj54l	108	36	dimers	dimer	NNS
cord-005941-e4fvj54l	108	37	[	[	-LRB-
cord-005941-e4fvj54l	108	38	84	84	CD
cord-005941-e4fvj54l	108	39	]	]	-RRB-
cord-005941-e4fvj54l	108	40	.	.	.
cord-005941-e4fvj54l	109	1	Furthermore	furthermore	RB
cord-005941-e4fvj54l	109	2	,	,	,
cord-005941-e4fvj54l	109	3	SP	SP	NNP
cord-005941-e4fvj54l	109	4	-	-	HYPH
cord-005941-e4fvj54l	109	5	B	B	NNP
cord-005941-e4fvj54l	109	6	has	have	VBZ
cord-005941-e4fvj54l	109	7	a	a	DT
cord-005941-e4fvj54l	109	8	strong	strong	JJ
cord-005941-e4fvj54l	109	9	positive	positive	JJ
cord-005941-e4fvj54l	109	10	net	net	JJ
cord-005941-e4fvj54l	109	11	charge	charge	NN
cord-005941-e4fvj54l	109	12	(	(	-LRB-
cord-005941-e4fvj54l	109	13	at	at	IN
cord-005941-e4fvj54l	109	14	physiological	physiological	JJ
cord-005941-e4fvj54l	109	15	pH	ph	NN
cord-005941-e4fvj54l	109	16	)	)	-RRB-
cord-005941-e4fvj54l	109	17	which	which	WDT
cord-005941-e4fvj54l	109	18	seems	seem	VBZ
cord-005941-e4fvj54l	109	19	to	to	TO
cord-005941-e4fvj54l	109	20	be	be	VB
cord-005941-e4fvj54l	109	21	important	important	JJ
cord-005941-e4fvj54l	109	22	to	to	IN
cord-005941-e4fvj54l	109	23	the	the	DT
cord-005941-e4fvj54l	109	24	interaction	interaction	NN
cord-005941-e4fvj54l	109	25	between	between	IN
cord-005941-e4fvj54l	109	26	SP	SP	NNP
cord-005941-e4fvj54l	109	27	-	-	HYPH
cord-005941-e4fvj54l	109	28	B	B	NNP
cord-005941-e4fvj54l	109	29	and	and	CC
cord-005941-e4fvj54l	109	30	the	the	DT
cord-005941-e4fvj54l	109	31	anionic	anionic	JJ
cord-005941-e4fvj54l	109	32	phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	109	33	[	[	-LRB-
cord-005941-e4fvj54l	109	34	23	23	CD
cord-005941-e4fvj54l	109	35	,	,	,
cord-005941-e4fvj54l	109	36	84	84	CD
cord-005941-e4fvj54l	109	37	]	]	-RRB-
cord-005941-e4fvj54l	109	38	.	.	.
cord-005941-e4fvj54l	110	1	However	however	RB
cord-005941-e4fvj54l	110	2	,	,	,
cord-005941-e4fvj54l	110	3	the	the	DT
cord-005941-e4fvj54l	110	4	structural	structural	JJ
cord-005941-e4fvj54l	110	5	interaction	interaction	NN
cord-005941-e4fvj54l	110	6	between	between	IN
cord-005941-e4fvj54l	110	7	SP	SP	NNP
cord-005941-e4fvj54l	110	8	-	-	HYPH
cord-005941-e4fvj54l	110	9	B	B	NNP
cord-005941-e4fvj54l	110	10	and	and	CC
cord-005941-e4fvj54l	110	11	other	other	JJ
cord-005941-e4fvj54l	110	12	surfactant	surfactant	NN
cord-005941-e4fvj54l	110	13	components	component	NNS
cord-005941-e4fvj54l	110	14	still	still	RB
cord-005941-e4fvj54l	110	15	has	have	VBZ
cord-005941-e4fvj54l	110	16	to	to	TO
cord-005941-e4fvj54l	110	17	be	be	VB
cord-005941-e4fvj54l	110	18	more	more	RBR
cord-005941-e4fvj54l	110	19	clearly	clearly	RB
cord-005941-e4fvj54l	110	20	defined	define	VBN
cord-005941-e4fvj54l	110	21	.	.	.
cord-005941-e4fvj54l	111	1	SP	SP	NNP
cord-005941-e4fvj54l	111	2	-	-	HYPH
cord-005941-e4fvj54l	111	3	C	C	NNP
cord-005941-e4fvj54l	111	4	is	be	VBZ
cord-005941-e4fvj54l	111	5	a	a	DT
cord-005941-e4fvj54l	111	6	very	very	RB
cord-005941-e4fvj54l	111	7	small	small	JJ
cord-005941-e4fvj54l	111	8	protein	protein	NN
cord-005941-e4fvj54l	111	9	with	with	IN
cord-005941-e4fvj54l	111	10	a	a	DT
cord-005941-e4fvj54l	111	11	molecular	molecular	JJ
cord-005941-e4fvj54l	111	12	weight	weight	NN
cord-005941-e4fvj54l	111	13	of	of	IN
cord-005941-e4fvj54l	111	14	approximately	approximately	RB
cord-005941-e4fvj54l	111	15	5	5	CD
cord-005941-e4fvj54l	111	16	kDa	kDa	NNS
cord-005941-e4fvj54l	111	17	.	.	.
cord-005941-e4fvj54l	112	1	It	-PRON-	PRP
cord-005941-e4fvj54l	112	2	is	be	VBZ
cord-005941-e4fvj54l	112	3	extremely	extremely	RB
cord-005941-e4fvj54l	112	4	hydrophobic	hydrophobic	JJ
cord-005941-e4fvj54l	112	5	,	,	,
cord-005941-e4fvj54l	112	6	which	which	WDT
cord-005941-e4fvj54l	112	7	is	be	VBZ
cord-005941-e4fvj54l	112	8	in	in	IN
cord-005941-e4fvj54l	112	9	part	part	NN
cord-005941-e4fvj54l	112	10	due	due	IN
cord-005941-e4fvj54l	112	11	to	to	IN
cord-005941-e4fvj54l	112	12	a	a	DT
cord-005941-e4fvj54l	112	13	high	high	JJ
cord-005941-e4fvj54l	112	14	content	content	NN
cord-005941-e4fvj54l	112	15	of	of	IN
cord-005941-e4fvj54l	112	16	the	the	DT
cord-005941-e4fvj54l	112	17	hydrophobic	hydrophobic	JJ
cord-005941-e4fvj54l	112	18	amino	amino	NN
cord-005941-e4fvj54l	112	19	acid	acid	NN
cord-005941-e4fvj54l	112	20	valine	valine	NN
cord-005941-e4fvj54l	112	21	[	[	-LRB-
cord-005941-e4fvj54l	112	22	145	145	CD
cord-005941-e4fvj54l	112	23	]	]	-RRB-
cord-005941-e4fvj54l	112	24	.	.	.
cord-005941-e4fvj54l	113	1	It	-PRON-	PRP
cord-005941-e4fvj54l	113	2	is	be	VBZ
cord-005941-e4fvj54l	113	3	therefore	therefore	RB
cord-005941-e4fvj54l	113	4	only	only	RB
cord-005941-e4fvj54l	113	5	soluble	soluble	JJ
cord-005941-e4fvj54l	113	6	in	in	IN
cord-005941-e4fvj54l	113	7	organic	organic	JJ
cord-005941-e4fvj54l	113	8	solvents	solvent	NNS
cord-005941-e4fvj54l	113	9	.	.	.
cord-005941-e4fvj54l	114	1	Small	small	JJ
cord-005941-e4fvj54l	114	2	size	size	NN
cord-005941-e4fvj54l	114	3	,	,	,
cord-005941-e4fvj54l	114	4	hydrophobicity	hydrophobicity	NN
cord-005941-e4fvj54l	114	5	,	,	,
cord-005941-e4fvj54l	114	6	and	and	CC
cord-005941-e4fvj54l	114	7	low	low	JJ
cord-005941-e4fvj54l	114	8	immunogenicity	immunogenicity	NN
cord-005941-e4fvj54l	114	9	make	make	VBP
cord-005941-e4fvj54l	114	10	the	the	DT
cord-005941-e4fvj54l	114	11	investigation	investigation	NN
cord-005941-e4fvj54l	114	12	of	of	IN
cord-005941-e4fvj54l	114	13	this	this	DT
cord-005941-e4fvj54l	114	14	protein	protein	NN
cord-005941-e4fvj54l	114	15	a	a	DT
cord-005941-e4fvj54l	114	16	difficult	difficult	JJ
cord-005941-e4fvj54l	114	17	task	task	NN
cord-005941-e4fvj54l	114	18	.	.	.
cord-005941-e4fvj54l	115	1	As	as	RB
cord-005941-e4fvj54l	115	2	far	far	RB
cord-005941-e4fvj54l	115	3	as	as	IN
cord-005941-e4fvj54l	115	4	its	-PRON-	PRP$
cord-005941-e4fvj54l	115	5	functional	functional	JJ
cord-005941-e4fvj54l	115	6	role	role	NN
cord-005941-e4fvj54l	115	7	in	in	IN
cord-005941-e4fvj54l	115	8	the	the	DT
cord-005941-e4fvj54l	115	9	surfactant	surfactant	NN
cord-005941-e4fvj54l	115	10	complex	complex	NN
cord-005941-e4fvj54l	115	11	is	be	VBZ
cord-005941-e4fvj54l	115	12	presently	presently	RB
cord-005941-e4fvj54l	115	13	understood	understand	VBN
cord-005941-e4fvj54l	115	14	,	,	,
cord-005941-e4fvj54l	115	15	it	-PRON-	PRP
cord-005941-e4fvj54l	115	16	contributes	contribute	VBZ
cord-005941-e4fvj54l	115	17	to	to	IN
cord-005941-e4fvj54l	115	18	the	the	DT
cord-005941-e4fvj54l	115	19	formation	formation	NN
cord-005941-e4fvj54l	115	20	and	and	CC
cord-005941-e4fvj54l	115	21	stabilization	stabilization	NN
cord-005941-e4fvj54l	115	22	of	of	IN
cord-005941-e4fvj54l	115	23	the	the	DT
cord-005941-e4fvj54l	115	24	alveolar	alveolar	NN
cord-005941-e4fvj54l	115	25	surfactant	surfactant	NN
cord-005941-e4fvj54l	115	26	monolayer	monolayer	NN
cord-005941-e4fvj54l	115	27	in	in	IN
cord-005941-e4fvj54l	115	28	cooperation	cooperation	NN
cord-005941-e4fvj54l	115	29	with	with	IN
cord-005941-e4fvj54l	115	30	SP	SP	NNP
cord-005941-e4fvj54l	115	31	-	-	HYPH
cord-005941-e4fvj54l	115	32	B	B	NNP
cord-005941-e4fvj54l	115	33	[	[	-LRB-
cord-005941-e4fvj54l	115	34	169	169	CD
cord-005941-e4fvj54l	115	35	]	]	-RRB-
cord-005941-e4fvj54l	115	36	.	.	.
cord-005941-e4fvj54l	116	1	Probably	probably	RB
cord-005941-e4fvj54l	116	2	,	,	,
cord-005941-e4fvj54l	116	3	SP	SP	NNP
cord-005941-e4fvj54l	116	4	-	-	HYPH
cord-005941-e4fvj54l	116	5	C	C	NNP
cord-005941-e4fvj54l	116	6	has	have	VBZ
cord-005941-e4fvj54l	116	7	no	no	DT
cord-005941-e4fvj54l	116	8	role	role	NN
cord-005941-e4fvj54l	116	9	in	in	IN
cord-005941-e4fvj54l	116	10	tubular	tubular	JJ
cord-005941-e4fvj54l	116	11	myelin	myelin	NN
cord-005941-e4fvj54l	116	12	formation	formation	NN
cord-005941-e4fvj54l	116	13	[	[	-LRB-
cord-005941-e4fvj54l	116	14	191	191	CD
cord-005941-e4fvj54l	116	15	]	]	-RRB-
cord-005941-e4fvj54l	116	16	.	.	.
cord-005941-e4fvj54l	117	1	The	the	DT
cord-005941-e4fvj54l	117	2	molecular	molecular	JJ
cord-005941-e4fvj54l	117	3	structure	structure	NN
cord-005941-e4fvj54l	117	4	and	and	CC
cord-005941-e4fvj54l	117	5	most	most	JJS
cord-005941-e4fvj54l	117	6	of	of	IN
cord-005941-e4fvj54l	117	7	the	the	DT
cord-005941-e4fvj54l	117	8	properties	property	NNS
cord-005941-e4fvj54l	117	9	of	of	IN
cord-005941-e4fvj54l	117	10	SP	SP	NNP
cord-005941-e4fvj54l	117	11	-	-	HYPH
cord-005941-e4fvj54l	117	12	C	C	NNP
cord-005941-e4fvj54l	117	13	are	be	VBP
cord-005941-e4fvj54l	117	14	substantially	substantially	RB
cord-005941-e4fvj54l	117	15	different	different	JJ
cord-005941-e4fvj54l	117	16	from	from	IN
cord-005941-e4fvj54l	117	17	SP	SP	NNP
cord-005941-e4fvj54l	117	18	-	-	HYPH
cord-005941-e4fvj54l	117	19	B	B	NNP
cord-005941-e4fvj54l	117	20	,	,	,
cord-005941-e4fvj54l	117	21	suggesting	suggest	VBG
cord-005941-e4fvj54l	117	22	that	that	IN
cord-005941-e4fvj54l	117	23	both	both	DT
cord-005941-e4fvj54l	117	24	proteins	protein	NNS
cord-005941-e4fvj54l	117	25	have	have	VBP
cord-005941-e4fvj54l	117	26	separate	separate	JJ
cord-005941-e4fvj54l	117	27	roles	role	NNS
cord-005941-e4fvj54l	117	28	in	in	IN
cord-005941-e4fvj54l	117	29	the	the	DT
cord-005941-e4fvj54l	117	30	surfactant	surfactant	NN
cord-005941-e4fvj54l	117	31	complex	complex	NN
cord-005941-e4fvj54l	117	32	.	.	.
cord-005941-e4fvj54l	118	1	Indeed	indeed	RB
cord-005941-e4fvj54l	118	2	,	,	,
cord-005941-e4fvj54l	118	3	in	in	IN
cord-005941-e4fvj54l	118	4	vitro	vitro	FW
cord-005941-e4fvj54l	118	5	studies	study	NNS
cord-005941-e4fvj54l	118	6	indicate	indicate	VBP
cord-005941-e4fvj54l	118	7	that	that	IN
cord-005941-e4fvj54l	118	8	SP	SP	NNP
cord-005941-e4fvj54l	118	9	-	-	HYPH
cord-005941-e4fvj54l	118	10	C	C	NNP
cord-005941-e4fvj54l	118	11	may	may	MD
cord-005941-e4fvj54l	118	12	be	be	VB
cord-005941-e4fvj54l	118	13	more	more	RBR
cord-005941-e4fvj54l	118	14	important	important	JJ
cord-005941-e4fvj54l	118	15	to	to	IN
cord-005941-e4fvj54l	118	16	the	the	DT
cord-005941-e4fvj54l	118	17	adsorption	adsorption	NN
cord-005941-e4fvj54l	118	18	of	of	IN
cord-005941-e4fvj54l	118	19	phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	118	20	,	,	,
cord-005941-e4fvj54l	118	21	while	while	IN
cord-005941-e4fvj54l	118	22	SP	SP	NNP
cord-005941-e4fvj54l	118	23	-	-	HYPH
cord-005941-e4fvj54l	118	24	B	B	NNP
cord-005941-e4fvj54l	118	25	supports	support	VBZ
cord-005941-e4fvj54l	118	26	the	the	DT
cord-005941-e4fvj54l	118	27	reduction	reduction	NN
cord-005941-e4fvj54l	118	28	of	of	IN
cord-005941-e4fvj54l	118	29	surface	surface	NN
cord-005941-e4fvj54l	118	30	tension	tension	NN
cord-005941-e4fvj54l	118	31	more	more	RBR
cord-005941-e4fvj54l	118	32	effectively	effectively	RB
cord-005941-e4fvj54l	118	33	[	[	-LRB-
cord-005941-e4fvj54l	118	34	199	199	CD
cord-005941-e4fvj54l	118	35	]	]	-RRB-
cord-005941-e4fvj54l	118	36	.	.	.
cord-005941-e4fvj54l	119	1	There	there	EX
cord-005941-e4fvj54l	119	2	seem	seem	VBP
cord-005941-e4fvj54l	119	3	to	to	TO
cord-005941-e4fvj54l	119	4	be	be	VB
cord-005941-e4fvj54l	119	5	no	no	DT
cord-005941-e4fvj54l	119	6	similarities	similarity	NNS
cord-005941-e4fvj54l	119	7	of	of	IN
cord-005941-e4fvj54l	119	8	SP	SP	NNP
cord-005941-e4fvj54l	119	9	-	-	HYPH
cord-005941-e4fvj54l	119	10	C	C	NNP
cord-005941-e4fvj54l	119	11	to	to	IN
cord-005941-e4fvj54l	119	12	other	other	JJ
cord-005941-e4fvj54l	119	13	proteins	protein	NNS
cord-005941-e4fvj54l	119	14	of	of	IN
cord-005941-e4fvj54l	119	15	known	know	VBN
cord-005941-e4fvj54l	119	16	functions	function	NNS
cord-005941-e4fvj54l	119	17	that	that	WDT
cord-005941-e4fvj54l	119	18	would	would	MD
cord-005941-e4fvj54l	119	19	suggest	suggest	VB
cord-005941-e4fvj54l	119	20	an	an	DT
cord-005941-e4fvj54l	119	21	additional	additional	JJ
cord-005941-e4fvj54l	119	22	role	role	NN
cord-005941-e4fvj54l	119	23	of	of	IN
cord-005941-e4fvj54l	119	24	SP	SP	NNP
cord-005941-e4fvj54l	119	25	-	-	HYPH
cord-005941-e4fvj54l	119	26	C	C	NNP
cord-005941-e4fvj54l	119	27	[	[	-LRB-
cord-005941-e4fvj54l	119	28	185	185	CD
cord-005941-e4fvj54l	119	29	]	]	-RRB-
cord-005941-e4fvj54l	119	30	.	.	.
cord-005941-e4fvj54l	120	1	SP	SP	NNP
cord-005941-e4fvj54l	120	2	-	-	HYPH
cord-005941-e4fvj54l	120	3	D	D	NNP
cord-005941-e4fvj54l	120	4	is	be	VBZ
cord-005941-e4fvj54l	120	5	a	a	DT
cord-005941-e4fvj54l	120	6	collagenous	collagenous	JJ
cord-005941-e4fvj54l	120	7	glycoprotein	glycoprotein	NN
cord-005941-e4fvj54l	120	8	synthesized	synthesize	VBN
cord-005941-e4fvj54l	120	9	by	by	IN
cord-005941-e4fvj54l	120	10	alveolar	alveolar	NN
cord-005941-e4fvj54l	120	11	type	type	NN
cord-005941-e4fvj54l	120	12	II	ii	CD
cord-005941-e4fvj54l	120	13	cells	cell	NNS
cord-005941-e4fvj54l	120	14	which	which	WDT
cord-005941-e4fvj54l	120	15	has	have	VBZ
cord-005941-e4fvj54l	120	16	only	only	RB
cord-005941-e4fvj54l	120	17	recently	recently	RB
cord-005941-e4fvj54l	120	18	been	be	VBN
cord-005941-e4fvj54l	120	19	described	describe	VBN
cord-005941-e4fvj54l	120	20	[	[	-LRB-
cord-005941-e4fvj54l	120	21	137	137	CD
cord-005941-e4fvj54l	120	22	,	,	,
cord-005941-e4fvj54l	120	23	138	138	CD
cord-005941-e4fvj54l	120	24	]	]	-RRB-
cord-005941-e4fvj54l	120	25	.	.	.
cord-005941-e4fvj54l	121	1	The	the	DT
cord-005941-e4fvj54l	121	2	question	question	NN
cord-005941-e4fvj54l	121	3	still	still	RB
cord-005941-e4fvj54l	121	4	remains	remain	VBZ
cord-005941-e4fvj54l	121	5	whether	whether	IN
cord-005941-e4fvj54l	121	6	this	this	DT
cord-005941-e4fvj54l	121	7	protein	protein	NN
cord-005941-e4fvj54l	121	8	is	be	VBZ
cord-005941-e4fvj54l	121	9	a	a	DT
cord-005941-e4fvj54l	121	10	true	true	JJ
cord-005941-e4fvj54l	121	11	surfactant	surfactant	NN
cord-005941-e4fvj54l	121	12	protein	protein	NN
cord-005941-e4fvj54l	121	13	or	or	CC
cord-005941-e4fvj54l	121	14	a	a	DT
cord-005941-e4fvj54l	121	15	protein	protein	NN
cord-005941-e4fvj54l	121	16	that	that	WDT
cord-005941-e4fvj54l	121	17	is	be	VBZ
cord-005941-e4fvj54l	121	18	synthesized	synthesize	VBN
cord-005941-e4fvj54l	121	19	independently	independently	RB
cord-005941-e4fvj54l	121	20	of	of	IN
cord-005941-e4fvj54l	121	21	the	the	DT
cord-005941-e4fvj54l	121	22	surfactent	surfactent	NNP
cord-005941-e4fvj54l	121	23	pathway	pathway	NN
cord-005941-e4fvj54l	121	24	and	and	CC
cord-005941-e4fvj54l	121	25	is	be	VBZ
cord-005941-e4fvj54l	121	26	only	only	RB
cord-005941-e4fvj54l	121	27	functionally	functionally	RB
cord-005941-e4fvj54l	121	28	associated	associate	VBN
cord-005941-e4fvj54l	121	29	with	with	IN
cord-005941-e4fvj54l	121	30	the	the	DT
cord-005941-e4fvj54l	121	31	surfactant	surfactant	NN
cord-005941-e4fvj54l	121	32	complex	complex	NN
cord-005941-e4fvj54l	121	33	.	.	.
cord-005941-e4fvj54l	122	1	In	in	IN
cord-005941-e4fvj54l	122	2	rat	rat	NN
cord-005941-e4fvj54l	122	3	bronchoalveolar	bronchoalveolar	NNP
cord-005941-e4fvj54l	122	4	lavage	lavage	NNP
cord-005941-e4fvj54l	122	5	(	(	-LRB-
cord-005941-e4fvj54l	122	6	BAL	BAL	NNP
cord-005941-e4fvj54l	122	7	)	)	-RRB-
cord-005941-e4fvj54l	122	8	fluids	fluid	NNS
cord-005941-e4fvj54l	122	9	,	,	,
cord-005941-e4fvj54l	122	10	the	the	DT
cord-005941-e4fvj54l	122	11	total	total	JJ
cord-005941-e4fvj54l	122	12	SP	SP	NNP
cord-005941-e4fvj54l	122	13	-	-	HYPH
cord-005941-e4fvj54l	122	14	D	d	JJ
cord-005941-e4fvj54l	122	15	content	content	NN
cord-005941-e4fvj54l	122	16	was	be	VBD
cord-005941-e4fvj54l	122	17	found	find	VBN
cord-005941-e4fvj54l	122	18	to	to	TO
cord-005941-e4fvj54l	122	19	be	be	VB
cord-005941-e4fvj54l	122	20	approximately	approximately	RB
cord-005941-e4fvj54l	122	21	12	12	CD
cord-005941-e4fvj54l	122	22	%	%	NN
cord-005941-e4fvj54l	122	23	of	of	IN
cord-005941-e4fvj54l	122	24	that	that	DT
cord-005941-e4fvj54l	122	25	of	of	IN
cord-005941-e4fvj54l	122	26	SP	SP	NNP
cord-005941-e4fvj54l	122	27	-	-	HYPH
cord-005941-e4fvj54l	122	28	A	A	NNP
cord-005941-e4fvj54l	122	29	[	[	-LRB-
cord-005941-e4fvj54l	122	30	99	99	CD
cord-005941-e4fvj54l	122	31	]	]	-RRB-
cord-005941-e4fvj54l	122	32	.	.	.
cord-005941-e4fvj54l	123	1	It	-PRON-	PRP
cord-005941-e4fvj54l	123	2	has	have	VBZ
cord-005941-e4fvj54l	123	3	a	a	DT
cord-005941-e4fvj54l	123	4	molecular	molecular	JJ
cord-005941-e4fvj54l	123	5	size	size	NN
cord-005941-e4fvj54l	123	6	of	of	IN
cord-005941-e4fvj54l	123	7	approximately	approximately	RB
cord-005941-e4fvj54l	123	8	43	43	CD
cord-005941-e4fvj54l	123	9	kDa	kDa	NNS
cord-005941-e4fvj54l	123	10	(	(	-LRB-
cord-005941-e4fvj54l	123	11	reduced	reduce	VBN
cord-005941-e4fvj54l	123	12	)	)	-RRB-
cord-005941-e4fvj54l	123	13	and	and	CC
cord-005941-e4fvj54l	123	14	appears	appear	VBZ
cord-005941-e4fvj54l	123	15	to	to	TO
cord-005941-e4fvj54l	123	16	build	build	VB
cord-005941-e4fvj54l	123	17	polymeric	polymeric	JJ
cord-005941-e4fvj54l	123	18	complexes	complex	NNS
cord-005941-e4fvj54l	123	19	comprised	comprise	VBN
cord-005941-e4fvj54l	123	20	of	of	IN
cord-005941-e4fvj54l	123	21	the	the	DT
cord-005941-e4fvj54l	123	22	43-kDa	43-kda	CD
cord-005941-e4fvj54l	123	23	subunits	subunit	NNS
cord-005941-e4fvj54l	123	24	.	.	.
cord-005941-e4fvj54l	124	1	SP	SP	NNP
cord-005941-e4fvj54l	124	2	-	-	HYPH
cord-005941-e4fvj54l	124	3	D	D	NNP
cord-005941-e4fvj54l	124	4	has	have	VBZ
cord-005941-e4fvj54l	124	5	certain	certain	JJ
cord-005941-e4fvj54l	124	6	structural	structural	JJ
cord-005941-e4fvj54l	124	7	similarities	similarity	NNS
cord-005941-e4fvj54l	124	8	with	with	IN
cord-005941-e4fvj54l	124	9	SP	SP	NNP
cord-005941-e4fvj54l	124	10	-	-	HYPH
cord-005941-e4fvj54l	124	11	A	A	NNP
cord-005941-e4fvj54l	124	12	and	and	CC
cord-005941-e4fvj54l	124	13	probably	probably	RB
cord-005941-e4fvj54l	124	14	is	be	VBZ
cord-005941-e4fvj54l	124	15	readily	readily	RB
cord-005941-e4fvj54l	124	16	soluble	soluble	JJ
cord-005941-e4fvj54l	124	17	in	in	IN
cord-005941-e4fvj54l	124	18	the	the	DT
cord-005941-e4fvj54l	124	19	alveolar	alveolar	JJ
cord-005941-e4fvj54l	124	20	milieu	milieu	NN
cord-005941-e4fvj54l	124	21	.	.	.
cord-005941-e4fvj54l	125	1	Like	like	IN
cord-005941-e4fvj54l	125	2	SP	SP	NNP
cord-005941-e4fvj54l	125	3	-	-	HYPH
cord-005941-e4fvj54l	125	4	A	A	NNP
cord-005941-e4fvj54l	125	5	,	,	,
cord-005941-e4fvj54l	125	6	SP	SP	NNP
cord-005941-e4fvj54l	125	7	-	-	HYPH
cord-005941-e4fvj54l	125	8	D	D	NNP
cord-005941-e4fvj54l	125	9	does	do	VBZ
cord-005941-e4fvj54l	125	10	not	not	RB
cord-005941-e4fvj54l	125	11	contribute	contribute	VB
cord-005941-e4fvj54l	125	12	to	to	IN
cord-005941-e4fvj54l	125	13	the	the	DT
cord-005941-e4fvj54l	125	14	surface	surface	NN
cord-005941-e4fvj54l	125	15	activity	activity	NN
cord-005941-e4fvj54l	125	16	of	of	IN
cord-005941-e4fvj54l	125	17	the	the	DT
cord-005941-e4fvj54l	125	18	surfactant	surfactant	NN
cord-005941-e4fvj54l	125	19	complex	complex	NN
cord-005941-e4fvj54l	125	20	[	[	-LRB-
cord-005941-e4fvj54l	125	21	137	137	CD
cord-005941-e4fvj54l	125	22	]	]	-RRB-
cord-005941-e4fvj54l	125	23	.	.	.
cord-005941-e4fvj54l	126	1	Its	-PRON-	PRP$
cord-005941-e4fvj54l	126	2	function	function	NN
cord-005941-e4fvj54l	126	3	is	be	VBZ
cord-005941-e4fvj54l	126	4	still	still	RB
cord-005941-e4fvj54l	126	5	hypothetical	hypothetical	JJ
cord-005941-e4fvj54l	126	6	.	.	.
cord-005941-e4fvj54l	127	1	Structural	structural	JJ
cord-005941-e4fvj54l	127	2	analogies	analogy	NNS
cord-005941-e4fvj54l	127	3	with	with	IN
cord-005941-e4fvj54l	127	4	proteins	protein	NNS
cord-005941-e4fvj54l	127	5	like	like	IN
cord-005941-e4fvj54l	127	6	mannosebinding	mannosebinde	VBG
cord-005941-e4fvj54l	127	7	protein	protein	NN
cord-005941-e4fvj54l	127	8	,	,	,
cord-005941-e4fvj54l	127	9	conglutinin	conglutinin	NNS
cord-005941-e4fvj54l	127	10	,	,	,
cord-005941-e4fvj54l	127	11	and	and	CC
cord-005941-e4fvj54l	127	12	SP	SP	NNP
cord-005941-e4fvj54l	127	13	-	-	HYPH
cord-005941-e4fvj54l	127	14	A	A	NNP
cord-005941-e4fvj54l	127	15	suggest	suggest	VBP
cord-005941-e4fvj54l	127	16	that	that	IN
cord-005941-e4fvj54l	127	17	it	-PRON-	PRP
cord-005941-e4fvj54l	127	18	may	may	MD
cord-005941-e4fvj54l	127	19	have	have	VB
cord-005941-e4fvj54l	127	20	a	a	DT
cord-005941-e4fvj54l	127	21	role	role	NN
cord-005941-e4fvj54l	127	22	in	in	IN
cord-005941-e4fvj54l	127	23	local	local	JJ
cord-005941-e4fvj54l	127	24	host	host	NN
cord-005941-e4fvj54l	127	25	defense	defense	NN
cord-005941-e4fvj54l	127	26	[	[	-LRB-
cord-005941-e4fvj54l	127	27	184	184	CD
cord-005941-e4fvj54l	127	28	]	]	-RRB-
cord-005941-e4fvj54l	127	29	,	,	,
cord-005941-e4fvj54l	127	30	perhaps	perhaps	RB
cord-005941-e4fvj54l	127	31	by	by	IN
cord-005941-e4fvj54l	127	32	functioning	function	VBG
cord-005941-e4fvj54l	127	33	like	like	IN
cord-005941-e4fvj54l	127	34	an	an	DT
cord-005941-e4fvj54l	127	35	opsonin	opsonin	NNS
cord-005941-e4fvj54l	127	36	.	.	.
cord-005941-e4fvj54l	128	1	A	a	DT
cord-005941-e4fvj54l	128	2	recent	recent	JJ
cord-005941-e4fvj54l	128	3	study	study	NN
cord-005941-e4fvj54l	128	4	indicates	indicate	VBZ
cord-005941-e4fvj54l	128	5	that	that	IN
cord-005941-e4fvj54l	128	6	SP	SP	NNP
cord-005941-e4fvj54l	128	7	-	-	HYPH
cord-005941-e4fvj54l	128	8	D	D	NNP
cord-005941-e4fvj54l	128	9	may	may	MD
cord-005941-e4fvj54l	128	10	also	also	RB
cord-005941-e4fvj54l	128	11	have	have	VB
cord-005941-e4fvj54l	128	12	regulatory	regulatory	JJ
cord-005941-e4fvj54l	128	13	functions	function	NNS
cord-005941-e4fvj54l	128	14	by	by	IN
cord-005941-e4fvj54l	128	15	counteracting	counteract	VBG
cord-005941-e4fvj54l	128	16	the	the	DT
cord-005941-e4fvj54l	128	17	inhibitory	inhibitory	JJ
cord-005941-e4fvj54l	128	18	effects	effect	NNS
cord-005941-e4fvj54l	128	19	of	of	IN
cord-005941-e4fvj54l	128	20	SP	SP	NNP
cord-005941-e4fvj54l	128	21	-	-	HYPH
cord-005941-e4fvj54l	128	22	A	a	NN
cord-005941-e4fvj54l	128	23	on	on	IN
cord-005941-e4fvj54l	128	24	phospholipid	phospholipid	NN
cord-005941-e4fvj54l	128	25	secretion	secretion	NN
cord-005941-e4fvj54l	128	26	by	by	IN
cord-005941-e4fvj54l	128	27	alveolar	alveolar	NN
cord-005941-e4fvj54l	128	28	type	type	NN
cord-005941-e4fvj54l	128	29	II	ii	CD
cord-005941-e4fvj54l	128	30	cells	cell	NNS
cord-005941-e4fvj54l	128	31	[	[	-LRB-
cord-005941-e4fvj54l	128	32	98	98	CD
cord-005941-e4fvj54l	128	33	]	]	-RRB-
cord-005941-e4fvj54l	128	34	.	.	.
cord-005941-e4fvj54l	129	1	The	the	DT
cord-005941-e4fvj54l	129	2	site	site	NN
cord-005941-e4fvj54l	129	3	of	of	IN
cord-005941-e4fvj54l	129	4	alveolar	alveolar	JJ
cord-005941-e4fvj54l	129	5	surfactant	surfactant	NN
cord-005941-e4fvj54l	129	6	synthesis	synthesis	NN
cord-005941-e4fvj54l	129	7	and	and	CC
cord-005941-e4fvj54l	129	8	secretion	secretion	NN
cord-005941-e4fvj54l	129	9	is	be	VBZ
cord-005941-e4fvj54l	129	10	the	the	DT
cord-005941-e4fvj54l	129	11	cuboidal	cuboidal	JJ
cord-005941-e4fvj54l	129	12	alveolar	alveolar	NN
cord-005941-e4fvj54l	129	13	type	type	NN
cord-005941-e4fvj54l	129	14	II	ii	CD
cord-005941-e4fvj54l	129	15	cell	cell	NN
cord-005941-e4fvj54l	129	16	which	which	WDT
cord-005941-e4fvj54l	129	17	covers	cover	VBZ
cord-005941-e4fvj54l	129	18	less	less	JJR
cord-005941-e4fvj54l	129	19	than	than	IN
cord-005941-e4fvj54l	129	20	5	5	CD
cord-005941-e4fvj54l	129	21	%	%	NN
cord-005941-e4fvj54l	129	22	of	of	IN
cord-005941-e4fvj54l	129	23	the	the	DT
cord-005941-e4fvj54l	129	24	alveolar	alveolar	NN
cord-005941-e4fvj54l	129	25	surface	surface	NN
cord-005941-e4fvj54l	129	26	.	.	.
cord-005941-e4fvj54l	130	1	There	there	EX
cord-005941-e4fvj54l	130	2	is	be	VBZ
cord-005941-e4fvj54l	130	3	evidence	evidence	NN
cord-005941-e4fvj54l	130	4	to	to	TO
cord-005941-e4fvj54l	130	5	suggest	suggest	VB
cord-005941-e4fvj54l	130	6	that	that	IN
cord-005941-e4fvj54l	130	7	surfactant	surfactant	NN
cord-005941-e4fvj54l	130	8	synthesis	synthesis	NN
cord-005941-e4fvj54l	130	9	and	and	CC
cord-005941-e4fvj54l	130	10	secretion	secretion	NN
cord-005941-e4fvj54l	130	11	in	in	IN
cord-005941-e4fvj54l	130	12	the	the	DT
cord-005941-e4fvj54l	130	13	lung	lung	NN
cord-005941-e4fvj54l	130	14	are	be	VBP
cord-005941-e4fvj54l	130	15	not	not	RB
cord-005941-e4fvj54l	130	16	exclusively	exclusively	RB
cord-005941-e4fvj54l	130	17	restricted	restrict	VBN
cord-005941-e4fvj54l	130	18	to	to	IN
cord-005941-e4fvj54l	130	19	the	the	DT
cord-005941-e4fvj54l	130	20	alveolar	alveolar	JJ
cord-005941-e4fvj54l	130	21	type	type	NN
cord-005941-e4fvj54l	130	22	II	ii	CD
cord-005941-e4fvj54l	130	23	cell	cell	NN
cord-005941-e4fvj54l	130	24	but	but	CC
cord-005941-e4fvj54l	130	25	that	that	IN
cord-005941-e4fvj54l	130	26	they	-PRON-	PRP
cord-005941-e4fvj54l	130	27	may	may	MD
cord-005941-e4fvj54l	130	28	also	also	RB
cord-005941-e4fvj54l	130	29	take	take	VB
cord-005941-e4fvj54l	130	30	place	place	NN
cord-005941-e4fvj54l	130	31	in	in	IN
cord-005941-e4fvj54l	130	32	higher	high	JJR
cord-005941-e4fvj54l	130	33	parts	part	NNS
cord-005941-e4fvj54l	130	34	of	of	IN
cord-005941-e4fvj54l	130	35	the	the	DT
cord-005941-e4fvj54l	130	36	airways	airway	NNS
cord-005941-e4fvj54l	130	37	,	,	,
cord-005941-e4fvj54l	130	38	for	for	IN
cord-005941-e4fvj54l	130	39	instance	instance	NN
cord-005941-e4fvj54l	130	40	in	in	IN
cord-005941-e4fvj54l	130	41	Clara	Clara	NNP
cord-005941-e4fvj54l	130	42	cells	cell	NNS
cord-005941-e4fvj54l	130	43	[	[	-LRB-
cord-005941-e4fvj54l	130	44	3	3	CD
cord-005941-e4fvj54l	130	45	,	,	,
cord-005941-e4fvj54l	130	46	170	170	CD
cord-005941-e4fvj54l	130	47	]	]	-RRB-
cord-005941-e4fvj54l	130	48	and	and	CC
cord-005941-e4fvj54l	130	49	possibly	possibly	RB
cord-005941-e4fvj54l	130	50	even	even	RB
cord-005941-e4fvj54l	130	51	in	in	IN
cord-005941-e4fvj54l	130	52	the	the	DT
cord-005941-e4fvj54l	130	53	tracheal	tracheal	JJ
cord-005941-e4fvj54l	130	54	epithelium	epithelium	NN
cord-005941-e4fvj54l	130	55	[	[	-LRB-
cord-005941-e4fvj54l	130	56	8	8	CD
cord-005941-e4fvj54l	130	57	]	]	-RRB-
cord-005941-e4fvj54l	130	58	.	.	.
cord-005941-e4fvj54l	131	1	This	this	DT
cord-005941-e4fvj54l	131	2	may	may	MD
cord-005941-e4fvj54l	131	3	contribute	contribute	VB
cord-005941-e4fvj54l	131	4	to	to	IN
cord-005941-e4fvj54l	131	5	normal	normal	JJ
cord-005941-e4fvj54l	131	6	mucociliary	mucociliary	JJ
cord-005941-e4fvj54l	131	7	function	function	NN
cord-005941-e4fvj54l	131	8	[	[	-LRB-
cord-005941-e4fvj54l	131	9	190	190	CD
cord-005941-e4fvj54l	131	10	]	]	-RRB-
cord-005941-e4fvj54l	131	11	.	.	.
cord-005941-e4fvj54l	132	1	However	however	RB
cord-005941-e4fvj54l	132	2	,	,	,
cord-005941-e4fvj54l	132	3	the	the	DT
cord-005941-e4fvj54l	132	4	significance	significance	NN
cord-005941-e4fvj54l	132	5	of	of	IN
cord-005941-e4fvj54l	132	6	these	these	DT
cord-005941-e4fvj54l	132	7	findings	finding	NNS
cord-005941-e4fvj54l	132	8	awaits	await	VBZ
cord-005941-e4fvj54l	132	9	further	further	JJ
cord-005941-e4fvj54l	132	10	investigation	investigation	NN
cord-005941-e4fvj54l	132	11	.	.	.
cord-005941-e4fvj54l	133	1	The	the	DT
cord-005941-e4fvj54l	133	2	alveolar	alveolar	NN
cord-005941-e4fvj54l	133	3	surfactant	surfactant	NN
cord-005941-e4fvj54l	133	4	components	component	NNS
cord-005941-e4fvj54l	133	5	are	be	VBP
cord-005941-e4fvj54l	133	6	synthesized	synthesize	VBN
cord-005941-e4fvj54l	133	7	and	and	CC
cord-005941-e4fvj54l	133	8	assembled	assemble	VBN
cord-005941-e4fvj54l	133	9	in	in	IN
cord-005941-e4fvj54l	133	10	the	the	DT
cord-005941-e4fvj54l	133	11	endoplasmic	endoplasmic	NN
cord-005941-e4fvj54l	133	12	reticulum	reticulum	NN
cord-005941-e4fvj54l	133	13	of	of	IN
cord-005941-e4fvj54l	133	14	alveolar	alveolar	JJ
cord-005941-e4fvj54l	133	15	type	type	NN
cord-005941-e4fvj54l	133	16	II	ii	CD
cord-005941-e4fvj54l	133	17	cells	cell	NNS
cord-005941-e4fvj54l	133	18	and	and	CC
cord-005941-e4fvj54l	133	19	then	then	RB
cord-005941-e4fvj54l	133	20	transferred	transfer	VBD
cord-005941-e4fvj54l	133	21	to	to	IN
cord-005941-e4fvj54l	133	22	the	the	DT
cord-005941-e4fvj54l	133	23	Golgi	Golgi	NNP
cord-005941-e4fvj54l	133	24	apparatus	apparatus	NN
cord-005941-e4fvj54l	133	25	prior	prior	RB
cord-005941-e4fvj54l	133	26	to	to	IN
cord-005941-e4fvj54l	133	27	forming	form	VBG
cord-005941-e4fvj54l	133	28	socalled	socalled	JJ
cord-005941-e4fvj54l	133	29	lamellar	lamellar	JJ
cord-005941-e4fvj54l	133	30	bodies	body	NNS
cord-005941-e4fvj54l	133	31	in	in	IN
cord-005941-e4fvj54l	133	32	the	the	DT
cord-005941-e4fvj54l	133	33	cytoplasm	cytoplasm	NN
cord-005941-e4fvj54l	133	34	(	(	-LRB-
cord-005941-e4fvj54l	133	35	Fig	fig	NN
cord-005941-e4fvj54l	133	36	.	.	NNP
cord-005941-e4fvj54l	133	37	2	2	CD
cord-005941-e4fvj54l	133	38	)	)	-RRB-
cord-005941-e4fvj54l	133	39	.	.	.
cord-005941-e4fvj54l	134	1	This	this	DT
cord-005941-e4fvj54l	134	2	process	process	NN
cord-005941-e4fvj54l	134	3	has	have	VBZ
cord-005941-e4fvj54l	134	4	been	be	VBN
cord-005941-e4fvj54l	134	5	followed	follow	VBN
cord-005941-e4fvj54l	134	6	by	by	IN
cord-005941-e4fvj54l	134	7	autoradiography	autoradiography	NNP
cord-005941-e4fvj54l	134	8	and	and	CC
cord-005941-e4fvj54l	134	9	by	by	IN
cord-005941-e4fvj54l	134	10	immunocytochemistry	immunocytochemistry	NNP
cord-005941-e4fvj54l	134	11	for	for	IN
cord-005941-e4fvj54l	134	12	phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	134	13	and	and	CC
cord-005941-e4fvj54l	134	14	SP	SP	NNP
cord-005941-e4fvj54l	134	15	-	-	HYPH
cord-005941-e4fvj54l	134	16	A	A	NNP
cord-005941-e4fvj54l	134	17	[	[	-LRB-
cord-005941-e4fvj54l	134	18	33	33	CD
cord-005941-e4fvj54l	134	19	]	]	-RRB-
cord-005941-e4fvj54l	134	20	.	.	.
cord-005941-e4fvj54l	135	1	As	as	IN
cord-005941-e4fvj54l	135	2	shown	show	VBN
cord-005941-e4fvj54l	135	3	by	by	IN
cord-005941-e4fvj54l	135	4	transmission	transmission	NN
cord-005941-e4fvj54l	135	5	electron	electron	NN
cord-005941-e4fvj54l	135	6	microscopy	microscopy	NN
cord-005941-e4fvj54l	135	7	[	[	-LRB-
cord-005941-e4fvj54l	135	8	122	122	CD
cord-005941-e4fvj54l	135	9	]	]	-RRB-
cord-005941-e4fvj54l	135	10	,	,	,
cord-005941-e4fvj54l	135	11	lamellar	lamellar	JJ
cord-005941-e4fvj54l	135	12	bodies	body	NNS
cord-005941-e4fvj54l	135	13	undergo	undergo	VBP
cord-005941-e4fvj54l	135	14	a	a	DT
cord-005941-e4fvj54l	135	15	process	process	NN
cord-005941-e4fvj54l	135	16	of	of	IN
cord-005941-e4fvj54l	135	17	maturation	maturation	NN
cord-005941-e4fvj54l	135	18	while	while	IN
cord-005941-e4fvj54l	135	19	travelling	travel	VBG
cord-005941-e4fvj54l	135	20	through	through	IN
cord-005941-e4fvj54l	135	21	the	the	DT
cord-005941-e4fvj54l	135	22	cytoplasm	cytoplasm	NN
cord-005941-e4fvj54l	135	23	and	and	CC
cord-005941-e4fvj54l	135	24	are	be	VBP
cord-005941-e4fvj54l	135	25	eventually	eventually	RB
cord-005941-e4fvj54l	135	26	transported	transport	VBN
cord-005941-e4fvj54l	135	27	into	into	IN
cord-005941-e4fvj54l	135	28	the	the	DT
cord-005941-e4fvj54l	135	29	alveolar	alveolar	JJ
cord-005941-e4fvj54l	135	30	space	space	NN
cord-005941-e4fvj54l	135	31	by	by	IN
cord-005941-e4fvj54l	135	32	merocrine	merocrine	NN
cord-005941-e4fvj54l	135	33	secretion	secretion	NN
cord-005941-e4fvj54l	135	34	after	after	IN
cord-005941-e4fvj54l	135	35	fusion	fusion	NN
cord-005941-e4fvj54l	135	36	with	with	IN
cord-005941-e4fvj54l	135	37	the	the	DT
cord-005941-e4fvj54l	135	38	cell	cell	NN
cord-005941-e4fvj54l	135	39	membrane	membrane	NN
cord-005941-e4fvj54l	135	40	.	.	.
cord-005941-e4fvj54l	136	1	Here	here	RB
cord-005941-e4fvj54l	136	2	,	,	,
cord-005941-e4fvj54l	136	3	the	the	DT
cord-005941-e4fvj54l	136	4	lamellar	lamellar	JJ
cord-005941-e4fvj54l	136	5	bodies	body	NNS
cord-005941-e4fvj54l	136	6	rapidly	rapidly	RB
cord-005941-e4fvj54l	136	7	transform	transform	VBP
cord-005941-e4fvj54l	136	8	into	into	IN
cord-005941-e4fvj54l	136	9	tubular	tubular	JJ
cord-005941-e4fvj54l	136	10	myelin	myelin	NN
cord-005941-e4fvj54l	136	11	,	,	,
cord-005941-e4fvj54l	136	12	an	an	DT
cord-005941-e4fvj54l	136	13	intermediate	intermediate	JJ
cord-005941-e4fvj54l	136	14	surfactant	surfactant	NN
cord-005941-e4fvj54l	136	15	material	material	NN
cord-005941-e4fvj54l	136	16	that	that	WDT
cord-005941-e4fvj54l	136	17	is	be	VBZ
cord-005941-e4fvj54l	136	18	composed	compose	VBN
cord-005941-e4fvj54l	136	19	of	of	IN
cord-005941-e4fvj54l	136	20	a	a	DT
cord-005941-e4fvj54l	136	21	lattice	lattice	NN
cord-005941-e4fvj54l	136	22	of	of	IN
cord-005941-e4fvj54l	136	23	highly	highly	RB
cord-005941-e4fvj54l	136	24	ordered	order	VBN
cord-005941-e4fvj54l	136	25	tubules	tubule	NNS
cord-005941-e4fvj54l	136	26	.	.	.
cord-005941-e4fvj54l	137	1	SP	SP	NNP
cord-005941-e4fvj54l	137	2	-	-	HYPH
cord-005941-e4fvj54l	137	3	A	A	NNP
cord-005941-e4fvj54l	137	4	is	be	VBZ
cord-005941-e4fvj54l	137	5	thought	think	VBN
cord-005941-e4fvj54l	137	6	to	to	TO
cord-005941-e4fvj54l	137	7	play	play	VB
cord-005941-e4fvj54l	137	8	a	a	DT
cord-005941-e4fvj54l	137	9	role	role	NN
cord-005941-e4fvj54l	137	10	in	in	IN
cord-005941-e4fvj54l	137	11	the	the	DT
cord-005941-e4fvj54l	137	12	formation	formation	NN
cord-005941-e4fvj54l	137	13	of	of	IN
cord-005941-e4fvj54l	137	14	tubular	tubular	JJ
cord-005941-e4fvj54l	137	15	myelin	myelin	NN
cord-005941-e4fvj54l	137	16	and	and	CC
cord-005941-e4fvj54l	137	17	has	have	VBZ
cord-005941-e4fvj54l	137	18	recently	recently	RB
cord-005941-e4fvj54l	137	19	been	be	VBN
cord-005941-e4fvj54l	137	20	located	locate	VBN
cord-005941-e4fvj54l	137	21	at	at	IN
cord-005941-e4fvj54l	137	22	the	the	DT
cord-005941-e4fvj54l	137	23	corners	corner	NNS
cord-005941-e4fvj54l	137	24	of	of	IN
cord-005941-e4fvj54l	137	25	the	the	DT
cord-005941-e4fvj54l	137	26	tubular	tubular	JJ
cord-005941-e4fvj54l	137	27	framework	framework	NN
cord-005941-e4fvj54l	137	28	by	by	IN
cord-005941-e4fvj54l	137	29	immune	immune	JJ
cord-005941-e4fvj54l	137	30	electron	electron	NN
cord-005941-e4fvj54l	137	31	microscopic	microscopic	JJ
cord-005941-e4fvj54l	137	32	techniques	technique	NNS
cord-005941-e4fvj54l	137	33	[	[	-LRB-
cord-005941-e4fvj54l	137	34	181	181	CD
cord-005941-e4fvj54l	137	35	]	]	-RRB-
cord-005941-e4fvj54l	137	36	.	.	.
cord-005941-e4fvj54l	138	1	Another	another	DT
cord-005941-e4fvj54l	138	2	recent	recent	JJ
cord-005941-e4fvj54l	138	3	in	in	IN
cord-005941-e4fvj54l	138	4	vitro	vitro	FW
cord-005941-e4fvj54l	138	5	study	study	NN
cord-005941-e4fvj54l	138	6	[	[	-LRB-
cord-005941-e4fvj54l	138	7	191	191	CD
cord-005941-e4fvj54l	138	8	]	]	-RRB-
cord-005941-e4fvj54l	138	9	suggests	suggest	VBZ
cord-005941-e4fvj54l	138	10	that	that	IN
cord-005941-e4fvj54l	138	11	in	in	IN
cord-005941-e4fvj54l	138	12	tubular	tubular	JJ
cord-005941-e4fvj54l	138	13	myelin	myelin	NN
cord-005941-e4fvj54l	138	14	formation	formation	NN
cord-005941-e4fvj54l	138	15	the	the	DT
cord-005941-e4fvj54l	138	16	presence	presence	NN
cord-005941-e4fvj54l	138	17	of	of	IN
cord-005941-e4fvj54l	138	18	SP	SP	NNP
cord-005941-e4fvj54l	138	19	-	-	HYPH
cord-005941-e4fvj54l	138	20	B	B	NNP
cord-005941-e4fvj54l	138	21	but	but	CC
cord-005941-e4fvj54l	138	22	not	not	RB
cord-005941-e4fvj54l	138	23	of	of	IN
cord-005941-e4fvj54l	138	24	SP	SP	NNP
cord-005941-e4fvj54l	138	25	-	-	HYPH
cord-005941-e4fvj54l	138	26	C	C	NNP
cord-005941-e4fvj54l	138	27	is	be	VBZ
cord-005941-e4fvj54l	138	28	necessary	necessary	JJ
cord-005941-e4fvj54l	138	29	in	in	IN
cord-005941-e4fvj54l	138	30	addition	addition	NN
cord-005941-e4fvj54l	138	31	to	to	IN
cord-005941-e4fvj54l	139	1	SP	SP	NNP
cord-005941-e4fvj54l	139	2	-	-	HYPH
cord-005941-e4fvj54l	139	3	A.	A.	NNP
cord-005941-e4fvj54l	139	4	Finally	finally	RB
cord-005941-e4fvj54l	139	5	,	,	,
cord-005941-e4fvj54l	139	6	this	this	DT
cord-005941-e4fvj54l	139	7	material	material	NN
cord-005941-e4fvj54l	139	8	is	be	VBZ
cord-005941-e4fvj54l	139	9	spread	spread	VBN
cord-005941-e4fvj54l	139	10	to	to	TO
cord-005941-e4fvj54l	139	11	reach	reach	VB
cord-005941-e4fvj54l	139	12	its	-PRON-	PRP$
cord-005941-e4fvj54l	139	13	definitive	definitive	JJ
cord-005941-e4fvj54l	139	14	form	form	NN
cord-005941-e4fvj54l	139	15	,	,	,
cord-005941-e4fvj54l	139	16	the	the	DT
cord-005941-e4fvj54l	139	17	surfactant	surfactant	NN
cord-005941-e4fvj54l	139	18	monolayer	monolayer	NN
cord-005941-e4fvj54l	139	19	(	(	-LRB-
cord-005941-e4fvj54l	139	20	Figs	fig	NNS
cord-005941-e4fvj54l	139	21	.	.	.
cord-005941-e4fvj54l	139	22	3	3	CD
cord-005941-e4fvj54l	139	23	,	,	,
cord-005941-e4fvj54l	139	24	4	4	CD
cord-005941-e4fvj54l	139	25	)	)	-RRB-
cord-005941-e4fvj54l	139	26	.	.	.
cord-005941-e4fvj54l	140	1	Pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	140	2	surfactant	surfactant	NN
cord-005941-e4fvj54l	140	3	is	be	VBZ
cord-005941-e4fvj54l	140	4	not	not	RB
cord-005941-e4fvj54l	140	5	a	a	DT
cord-005941-e4fvj54l	140	6	static	static	JJ
cord-005941-e4fvj54l	140	7	accessory	accessory	NN
cord-005941-e4fvj54l	140	8	of	of	IN
cord-005941-e4fvj54l	140	9	the	the	DT
cord-005941-e4fvj54l	140	10	alveolus	alveolus	NN
cord-005941-e4fvj54l	140	11	but	but	CC
cord-005941-e4fvj54l	140	12	undergoes	undergo	VBZ
cord-005941-e4fvj54l	140	13	a	a	DT
cord-005941-e4fvj54l	140	14	constant	constant	JJ
cord-005941-e4fvj54l	140	15	dynamic	dynamic	JJ
cord-005941-e4fvj54l	140	16	process	process	NN
cord-005941-e4fvj54l	140	17	of	of	IN
cord-005941-e4fvj54l	140	18	turnover	turnover	NN
cord-005941-e4fvj54l	140	19	and	and	CC
cord-005941-e4fvj54l	140	20	metabolism	metabolism	NN
cord-005941-e4fvj54l	140	21	.	.	.
cord-005941-e4fvj54l	141	1	This	this	DT
cord-005941-e4fvj54l	141	2	review	review	NN
cord-005941-e4fvj54l	141	3	will	will	MD
cord-005941-e4fvj54l	141	4	present	present	VB
cord-005941-e4fvj54l	141	5	only	only	RB
cord-005941-e4fvj54l	141	6	a	a	DT
cord-005941-e4fvj54l	141	7	short	short	JJ
cord-005941-e4fvj54l	141	8	summary	summary	NN
cord-005941-e4fvj54l	141	9	of	of	IN
cord-005941-e4fvj54l	141	10	the	the	DT
cord-005941-e4fvj54l	141	11	present	present	JJ
cord-005941-e4fvj54l	141	12	knowledge	knowledge	NN
cord-005941-e4fvj54l	141	13	on	on	IN
cord-005941-e4fvj54l	141	14	these	these	DT
cord-005941-e4fvj54l	141	15	processes	process	NNS
cord-005941-e4fvj54l	141	16	.	.	.
cord-005941-e4fvj54l	142	1	For	for	IN
cord-005941-e4fvj54l	142	2	more	more	RBR
cord-005941-e4fvj54l	142	3	detailed	detailed	JJ
cord-005941-e4fvj54l	142	4	information	information	NN
cord-005941-e4fvj54l	142	5	,	,	,
cord-005941-e4fvj54l	142	6	the	the	DT
cord-005941-e4fvj54l	142	7	interested	interested	JJ
cord-005941-e4fvj54l	142	8	reader	reader	NN
cord-005941-e4fvj54l	142	9	is	be	VBZ
cord-005941-e4fvj54l	142	10	referred	refer	VBN
cord-005941-e4fvj54l	142	11	to	to	IN
cord-005941-e4fvj54l	142	12	a	a	DT
cord-005941-e4fvj54l	142	13	number	number	NN
cord-005941-e4fvj54l	142	14	of	of	IN
cord-005941-e4fvj54l	142	15	recently	recently	RB
cord-005941-e4fvj54l	142	16	published	publish	VBN
cord-005941-e4fvj54l	142	17	reviews	review	NNS
cord-005941-e4fvj54l	142	18	which	which	WDT
cord-005941-e4fvj54l	142	19	emphasize	emphasize	VBP
cord-005941-e4fvj54l	142	20	these	these	DT
cord-005941-e4fvj54l	142	21	aspects	aspect	NNS
cord-005941-e4fvj54l	142	22	[	[	-LRB-
cord-005941-e4fvj54l	142	23	17	17	CD
cord-005941-e4fvj54l	142	24	,	,	,
cord-005941-e4fvj54l	142	25	18	18	CD
cord-005941-e4fvj54l	142	26	,	,	,
cord-005941-e4fvj54l	142	27	56	56	CD
cord-005941-e4fvj54l	142	28	,	,	,
cord-005941-e4fvj54l	142	29	65	65	CD
cord-005941-e4fvj54l	142	30	,	,	,
cord-005941-e4fvj54l	142	31	174	174	CD
cord-005941-e4fvj54l	142	32	-	-	SYM
cord-005941-e4fvj54l	142	33	176	176	CD
cord-005941-e4fvj54l	142	34	,	,	,
cord-005941-e4fvj54l	142	35	185	185	CD
cord-005941-e4fvj54l	142	36	,	,	,
cord-005941-e4fvj54l	142	37	196	196	CD
cord-005941-e4fvj54l	142	38	,	,	,
cord-005941-e4fvj54l	142	39	197	197	CD
cord-005941-e4fvj54l	142	40	]	]	-RRB-
cord-005941-e4fvj54l	142	41	.	.	.
cord-005941-e4fvj54l	143	1	Basically	basically	RB
cord-005941-e4fvj54l	143	2	,	,	,
cord-005941-e4fvj54l	143	3	all	all	DT
cord-005941-e4fvj54l	143	4	phospholipid	phospholipid	NN
cord-005941-e4fvj54l	143	5	components	component	NNS
cord-005941-e4fvj54l	143	6	of	of	IN
cord-005941-e4fvj54l	143	7	surfactant	surfactant	NN
cord-005941-e4fvj54l	143	8	seem	seem	VBP
cord-005941-e4fvj54l	143	9	to	to	TO
cord-005941-e4fvj54l	143	10	be	be	VB
cord-005941-e4fvj54l	143	11	synthesized	synthesize	VBN
cord-005941-e4fvj54l	143	12	and	and	CC
cord-005941-e4fvj54l	143	13	incorporated	incorporate	VBN
cord-005941-e4fvj54l	143	14	into	into	IN
cord-005941-e4fvj54l	143	15	the	the	DT
cord-005941-e4fvj54l	143	16	lamellar	lamellar	JJ
cord-005941-e4fvj54l	143	17	bodies	body	NNS
cord-005941-e4fvj54l	143	18	within	within	IN
cord-005941-e4fvj54l	143	19	the	the	DT
cord-005941-e4fvj54l	143	20	alveolar	alveolar	JJ
cord-005941-e4fvj54l	143	21	type	type	NN
cord-005941-e4fvj54l	143	22	II	ii	CD
cord-005941-e4fvj54l	143	23	cell	cell	NN
cord-005941-e4fvj54l	143	24	.	.	.
cord-005941-e4fvj54l	144	1	This	this	DT
cord-005941-e4fvj54l	144	2	is	be	VBZ
cord-005941-e4fvj54l	144	3	supported	support	VBN
cord-005941-e4fvj54l	144	4	by	by	IN
cord-005941-e4fvj54l	144	5	findings	finding	NNS
cord-005941-e4fvj54l	144	6	that	that	IN
cord-005941-e4fvj54l	144	7	the	the	DT
cord-005941-e4fvj54l	144	8	phospholipid	phospholipid	NN
cord-005941-e4fvj54l	144	9	composition	composition	NN
cord-005941-e4fvj54l	144	10	of	of	IN
cord-005941-e4fvj54l	144	11	isolated	isolate	VBN
cord-005941-e4fvj54l	144	12	lamellar	lamellar	JJ
cord-005941-e4fvj54l	144	13	bodies	body	NNS
cord-005941-e4fvj54l	144	14	is	be	VBZ
cord-005941-e4fvj54l	144	15	virtually	virtually	RB
cord-005941-e4fvj54l	144	16	identical	identical	JJ
cord-005941-e4fvj54l	144	17	to	to	IN
cord-005941-e4fvj54l	144	18	that	that	DT
cord-005941-e4fvj54l	144	19	of	of	IN
cord-005941-e4fvj54l	144	20	BAL	BAL	NNP
cord-005941-e4fvj54l	144	21	[	[	-LRB-
cord-005941-e4fvj54l	144	22	197	197	CD
cord-005941-e4fvj54l	144	23	]	]	-RRB-
cord-005941-e4fvj54l	144	24	.	.	.
cord-005941-e4fvj54l	145	1	DPPC	DPPC	NNP
cord-005941-e4fvj54l	145	2	is	be	VBZ
cord-005941-e4fvj54l	145	3	the	the	DT
cord-005941-e4fvj54l	145	4	best	well	RBS
cord-005941-e4fvj54l	145	5	studied	study	VBN
cord-005941-e4fvj54l	145	6	phospholipid	phospholipid	NN
cord-005941-e4fvj54l	145	7	regarding	regard	VBG
cord-005941-e4fvj54l	145	8	intracellular	intracellular	JJ
cord-005941-e4fvj54l	145	9	synthesis	synthesis	NN
cord-005941-e4fvj54l	145	10	pathways	pathway	NNS
cord-005941-e4fvj54l	145	11	.	.	.
cord-005941-e4fvj54l	146	1	It	-PRON-	PRP
cord-005941-e4fvj54l	146	2	is	be	VBZ
cord-005941-e4fvj54l	146	3	de	de	FW
cord-005941-e4fvj54l	146	4	novo	novo	NNP
cord-005941-e4fvj54l	146	5	synthesized	synthesize	VBN
cord-005941-e4fvj54l	146	6	from	from	IN
cord-005941-e4fvj54l	146	7	blood	blood	NN
cord-005941-e4fvj54l	146	8	-	-	HYPH
cord-005941-e4fvj54l	146	9	derived	derive	VBN
cord-005941-e4fvj54l	146	10	phospholipid	phospholipid	NN
cord-005941-e4fvj54l	146	11	precursors	precursor	NNS
cord-005941-e4fvj54l	146	12	and	and	CC
cord-005941-e4fvj54l	146	13	can	can	MD
cord-005941-e4fvj54l	146	14	probably	probably	RB
cord-005941-e4fvj54l	146	15	also	also	RB
cord-005941-e4fvj54l	146	16	be	be	VB
cord-005941-e4fvj54l	146	17	remodelled	remodelle	VBN
cord-005941-e4fvj54l	146	18	from	from	IN
cord-005941-e4fvj54l	146	19	unsaturated	unsaturated	JJ
cord-005941-e4fvj54l	146	20	or	or	CC
cord-005941-e4fvj54l	146	21	recycled	recycled	JJ
cord-005941-e4fvj54l	146	22	phosphatidylcholine	phosphatidylcholine	NN
cord-005941-e4fvj54l	146	23	.	.	.
cord-005941-e4fvj54l	147	1	Less	Less	JJR
cord-005941-e4fvj54l	147	2	evidence	evidence	NN
cord-005941-e4fvj54l	147	3	exists	exist	VBZ
cord-005941-e4fvj54l	147	4	on	on	IN
cord-005941-e4fvj54l	147	5	the	the	DT
cord-005941-e4fvj54l	147	6	synthesis	synthesis	NN
cord-005941-e4fvj54l	147	7	and	and	CC
cord-005941-e4fvj54l	147	8	precise	precise	JJ
cord-005941-e4fvj54l	147	9	pathways	pathway	NNS
cord-005941-e4fvj54l	147	10	of	of	IN
cord-005941-e4fvj54l	147	11	secretion	secretion	NN
cord-005941-e4fvj54l	147	12	of	of	IN
cord-005941-e4fvj54l	147	13	the	the	DT
cord-005941-e4fvj54l	147	14	surfactant	surfactant	NN
cord-005941-e4fvj54l	147	15	-	-	HYPH
cord-005941-e4fvj54l	147	16	specific	specific	JJ
cord-005941-e4fvj54l	147	17	proteins	protein	NNS
cord-005941-e4fvj54l	147	18	.	.	.
cord-005941-e4fvj54l	148	1	Alveolar	alveolar	NN
cord-005941-e4fvj54l	148	2	SP	SP	NNP
cord-005941-e4fvj54l	148	3	-	-	HYPH
cord-005941-e4fvj54l	148	4	A	a	DT
cord-005941-e4fvj54l	148	5	gene	gene	NN
cord-005941-e4fvj54l	148	6	expression	expression	NN
cord-005941-e4fvj54l	148	7	is	be	VBZ
cord-005941-e4fvj54l	148	8	restricted	restrict	VBN
cord-005941-e4fvj54l	148	9	to	to	IN
cord-005941-e4fvj54l	148	10	the	the	DT
cord-005941-e4fvj54l	148	11	alveolar	alveolar	JJ
cord-005941-e4fvj54l	148	12	type	type	NN
cord-005941-e4fvj54l	148	13	II	ii	CD
cord-005941-e4fvj54l	148	14	cell	cell	NN
cord-005941-e4fvj54l	148	15	as	as	IN
cord-005941-e4fvj54l	148	16	shown	show	VBN
cord-005941-e4fvj54l	148	17	by	by	IN
cord-005941-e4fvj54l	148	18	in	in	IN
cord-005941-e4fvj54l	148	19	situ	situ	NN
cord-005941-e4fvj54l	148	20	hybridization	hybridization	NN
cord-005941-e4fvj54l	148	21	[	[	-LRB-
cord-005941-e4fvj54l	148	22	141	141	CD
cord-005941-e4fvj54l	148	23	]	]	-RRB-
cord-005941-e4fvj54l	148	24	.	.	.
cord-005941-e4fvj54l	149	1	It	-PRON-	PRP
cord-005941-e4fvj54l	149	2	is	be	VBZ
cord-005941-e4fvj54l	149	3	synthesized	synthesize	VBN
cord-005941-e4fvj54l	149	4	as	as	IN
cord-005941-e4fvj54l	149	5	a	a	DT
cord-005941-e4fvj54l	149	6	preprotein	preprotein	NN
cord-005941-e4fvj54l	149	7	of	of	IN
cord-005941-e4fvj54l	149	8	approximately	approximately	RB
cord-005941-e4fvj54l	149	9	29	29	CD
cord-005941-e4fvj54l	149	10	kDa	kDa	NNS
cord-005941-e4fvj54l	149	11	and	and	CC
cord-005941-e4fvj54l	149	12	a	a	DT
cord-005941-e4fvj54l	149	13	second	second	JJ
cord-005941-e4fvj54l	149	14	variant	variant	NN
cord-005941-e4fvj54l	149	15	of	of	IN
cord-005941-e4fvj54l	149	16	approximately	approximately	RB
cord-005941-e4fvj54l	149	17	31	31	CD
cord-005941-e4fvj54l	149	18	kDa	kDa	NNS
cord-005941-e4fvj54l	149	19	.	.	.
cord-005941-e4fvj54l	150	1	Different	different	JJ
cord-005941-e4fvj54l	150	2	posttranslational	posttranslational	JJ
cord-005941-e4fvj54l	150	3	modifications	modification	NNS
cord-005941-e4fvj54l	150	4	of	of	IN
cord-005941-e4fvj54l	150	5	this	this	DT
cord-005941-e4fvj54l	150	6	protein	protein	NN
cord-005941-e4fvj54l	150	7	like	like	IN
cord-005941-e4fvj54l	150	8	sialylation	sialylation	NN
cord-005941-e4fvj54l	150	9	,	,	,
cord-005941-e4fvj54l	150	10	acetylation	acetylation	NN
cord-005941-e4fvj54l	150	11	,	,	,
cord-005941-e4fvj54l	150	12	and	and	CC
cord-005941-e4fvj54l	150	13	sulfation	sulfation	NN
cord-005941-e4fvj54l	150	14	have	have	VBP
cord-005941-e4fvj54l	150	15	been	be	VBN
cord-005941-e4fvj54l	150	16	described	describe	VBN
cord-005941-e4fvj54l	150	17	[	[	-LRB-
cord-005941-e4fvj54l	150	18	145	145	CD
cord-005941-e4fvj54l	150	19	]	]	-RRB-
cord-005941-e4fvj54l	150	20	.	.	.
cord-005941-e4fvj54l	151	1	Single	single	JJ
cord-005941-e4fvj54l	151	2	SP	SP	NNP
cord-005941-e4fvj54l	151	3	-	-	HYPH
cord-005941-e4fvj54l	151	4	A	a	DT
cord-005941-e4fvj54l	151	5	monomeres	monomere	NNS
cord-005941-e4fvj54l	151	6	are	be	VBP
cord-005941-e4fvj54l	151	7	oligomerized	oligomerize	VBN
cord-005941-e4fvj54l	151	8	to	to	IN
cord-005941-e4fvj54l	151	9	hexameric	hexameric	JJ
cord-005941-e4fvj54l	151	10	bundles	bundle	NNS
cord-005941-e4fvj54l	151	11	resembling	resemble	VBG
cord-005941-e4fvj54l	151	12	flower	flower	NN
cord-005941-e4fvj54l	151	13	bouquets	bouquet	NNS
cord-005941-e4fvj54l	151	14	[	[	-LRB-
cord-005941-e4fvj54l	151	15	182	182	CD
cord-005941-e4fvj54l	151	16	]	]	-RRB-
cord-005941-e4fvj54l	151	17	.	.	.
cord-005941-e4fvj54l	152	1	Probably	probably	RB
cord-005941-e4fvj54l	152	2	,	,	,
cord-005941-e4fvj54l	152	3	surfactant	surfactant	NN
cord-005941-e4fvj54l	152	4	proteins	protein	NNS
cord-005941-e4fvj54l	152	5	and	and	CC
cord-005941-e4fvj54l	152	6	the	the	DT
cord-005941-e4fvj54l	152	7	phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	152	8	are	be	VBP
cord-005941-e4fvj54l	152	9	all	all	DT
cord-005941-e4fvj54l	152	10	assembled	assemble	VBN
cord-005941-e4fvj54l	152	11	and	and	CC
cord-005941-e4fvj54l	152	12	introduced	introduce	VBN
cord-005941-e4fvj54l	152	13	into	into	IN
cord-005941-e4fvj54l	152	14	the	the	DT
cord-005941-e4fvj54l	152	15	lamellar	lamellar	JJ
cord-005941-e4fvj54l	152	16	bodies	body	NNS
cord-005941-e4fvj54l	152	17	within	within	IN
cord-005941-e4fvj54l	152	18	the	the	DT
cord-005941-e4fvj54l	152	19	type	type	NN
cord-005941-e4fvj54l	152	20	II	ii	CD
cord-005941-e4fvj54l	152	21	cell	cell	NN
cord-005941-e4fvj54l	152	22	before	before	IN
cord-005941-e4fvj54l	152	23	secretion	secretion	NN
cord-005941-e4fvj54l	152	24	[	[	-LRB-
cord-005941-e4fvj54l	152	25	185	185	CD
cord-005941-e4fvj54l	152	26	]	]	-RRB-
cord-005941-e4fvj54l	152	27	.	.	.
cord-005941-e4fvj54l	153	1	However	however	RB
cord-005941-e4fvj54l	153	2	,	,	,
cord-005941-e4fvj54l	153	3	many	many	JJ
cord-005941-e4fvj54l	153	4	details	detail	NNS
cord-005941-e4fvj54l	153	5	of	of	IN
cord-005941-e4fvj54l	153	6	this	this	DT
cord-005941-e4fvj54l	153	7	process	process	NN
cord-005941-e4fvj54l	153	8	remain	remain	VBP
cord-005941-e4fvj54l	153	9	to	to	TO
cord-005941-e4fvj54l	153	10	be	be	VB
cord-005941-e4fvj54l	153	11	investigated	investigate	VBN
cord-005941-e4fvj54l	153	12	.	.	.
cord-005941-e4fvj54l	154	1	For	for	IN
cord-005941-e4fvj54l	154	2	instance	instance	NN
cord-005941-e4fvj54l	154	3	,	,	,
cord-005941-e4fvj54l	154	4	it	-PRON-	PRP
cord-005941-e4fvj54l	154	5	is	be	VBZ
cord-005941-e4fvj54l	154	6	not	not	RB
cord-005941-e4fvj54l	154	7	yet	yet	RB
cord-005941-e4fvj54l	154	8	quite	quite	RB
cord-005941-e4fvj54l	154	9	certain	certain	JJ
cord-005941-e4fvj54l	154	10	whether	whether	IN
cord-005941-e4fvj54l	154	11	all	all	DT
cord-005941-e4fvj54l	154	12	of	of	IN
cord-005941-e4fvj54l	154	13	the	the	DT
cord-005941-e4fvj54l	154	14	individual	individual	JJ
cord-005941-e4fvj54l	154	15	proteins	protein	NNS
cord-005941-e4fvj54l	154	16	are	be	VBP
cord-005941-e4fvj54l	154	17	introduced	introduce	VBN
cord-005941-e4fvj54l	154	18	into	into	IN
cord-005941-e4fvj54l	154	19	the	the	DT
cord-005941-e4fvj54l	154	20	lamellar	lamellar	JJ
cord-005941-e4fvj54l	154	21	bodies	body	NNS
cord-005941-e4fvj54l	154	22	or	or	CC
cord-005941-e4fvj54l	154	23	if	if	IN
cord-005941-e4fvj54l	154	24	some	some	DT
cord-005941-e4fvj54l	154	25	of	of	IN
cord-005941-e4fvj54l	154	26	them	-PRON-	PRP
cord-005941-e4fvj54l	154	27	join	join	VBP
cord-005941-e4fvj54l	154	28	the	the	DT
cord-005941-e4fvj54l	154	29	surfactant	surfactant	NN
cord-005941-e4fvj54l	154	30	complex	complex	NN
cord-005941-e4fvj54l	154	31	after	after	IN
cord-005941-e4fvj54l	154	32	secretion	secretion	NN
cord-005941-e4fvj54l	154	33	into	into	IN
cord-005941-e4fvj54l	154	34	the	the	DT
cord-005941-e4fvj54l	154	35	alveolar	alveolar	JJ
cord-005941-e4fvj54l	154	36	space	space	NN
cord-005941-e4fvj54l	154	37	[	[	-LRB-
cord-005941-e4fvj54l	154	38	56	56	CD
cord-005941-e4fvj54l	154	39	]	]	-RRB-
cord-005941-e4fvj54l	154	40	.	.	.
cord-005941-e4fvj54l	155	1	Fur	fur	NN
cord-005941-e4fvj54l	155	2	-	-	HYPH
cord-005941-e4fvj54l	155	3	thermore	thermore	NN
cord-005941-e4fvj54l	155	4	,	,	,
cord-005941-e4fvj54l	155	5	no	no	DT
cord-005941-e4fvj54l	155	6	evidence	evidence	NN
cord-005941-e4fvj54l	155	7	exists	exist	VBZ
cord-005941-e4fvj54l	155	8	on	on	IN
cord-005941-e4fvj54l	155	9	the	the	DT
cord-005941-e4fvj54l	155	10	possible	possible	JJ
cord-005941-e4fvj54l	155	11	association	association	NN
cord-005941-e4fvj54l	155	12	of	of	IN
cord-005941-e4fvj54l	155	13	SP	SP	NNP
cord-005941-e4fvj54l	155	14	-	-	HYPH
cord-005941-e4fvj54l	155	15	D	D	NNP
cord-005941-e4fvj54l	155	16	with	with	IN
cord-005941-e4fvj54l	155	17	intracellular	intracellular	JJ
cord-005941-e4fvj54l	155	18	lamellar	lamellar	JJ
cord-005941-e4fvj54l	155	19	bodies	body	NNS
cord-005941-e4fvj54l	155	20	and	and	CC
cord-005941-e4fvj54l	155	21	their	-PRON-	PRP$
cord-005941-e4fvj54l	155	22	secretion	secretion	NN
cord-005941-e4fvj54l	155	23	.	.	.
cord-005941-e4fvj54l	156	1	Surfactant	surfactant	NN
cord-005941-e4fvj54l	156	2	synthesis	synthesis	NN
cord-005941-e4fvj54l	156	3	has	have	VBZ
cord-005941-e4fvj54l	156	4	been	be	VBN
cord-005941-e4fvj54l	156	5	found	find	VBN
cord-005941-e4fvj54l	156	6	to	to	TO
cord-005941-e4fvj54l	156	7	be	be	VB
cord-005941-e4fvj54l	156	8	influenced	influence	VBN
cord-005941-e4fvj54l	156	9	by	by	IN
cord-005941-e4fvj54l	156	10	a	a	DT
cord-005941-e4fvj54l	156	11	number	number	NN
cord-005941-e4fvj54l	156	12	of	of	IN
cord-005941-e4fvj54l	156	13	different	different	JJ
cord-005941-e4fvj54l	156	14	stimuli	stimulus	NNS
cord-005941-e4fvj54l	156	15	[	[	-LRB-
cord-005941-e4fvj54l	156	16	7	7	CD
cord-005941-e4fvj54l	156	17	]	]	-RRB-
cord-005941-e4fvj54l	157	1	(	(	-LRB-
cord-005941-e4fvj54l	157	2	Table	table	NN
cord-005941-e4fvj54l	157	3	2	2	CD
cord-005941-e4fvj54l	157	4	)	)	-RRB-
cord-005941-e4fvj54l	157	5	.	.	.
cord-005941-e4fvj54l	158	1	Glucocorticoids	Glucocorticoids	NNP
cord-005941-e4fvj54l	158	2	,	,	,
cord-005941-e4fvj54l	158	3	cAMP	camp	NN
cord-005941-e4fvj54l	158	4	,	,	,
cord-005941-e4fvj54l	158	5	oestrogens	oestrogen	NNS
cord-005941-e4fvj54l	158	6	,	,	,
cord-005941-e4fvj54l	158	7	and	and	CC
cord-005941-e4fvj54l	158	8	thyroid	thyroid	JJ
cord-005941-e4fvj54l	158	9	hormones	hormone	NNS
cord-005941-e4fvj54l	158	10	,	,	,
cord-005941-e4fvj54l	158	11	among	among	IN
cord-005941-e4fvj54l	158	12	others	other	NNS
cord-005941-e4fvj54l	158	13	,	,	,
cord-005941-e4fvj54l	158	14	have	have	VBP
cord-005941-e4fvj54l	158	15	been	be	VBN
cord-005941-e4fvj54l	158	16	described	describe	VBN
cord-005941-e4fvj54l	158	17	as	as	IN
cord-005941-e4fvj54l	158	18	enhancing	enhance	VBG
cord-005941-e4fvj54l	158	19	surfactant	surfactant	NN
cord-005941-e4fvj54l	158	20	synthesis	synthesis	NN
cord-005941-e4fvj54l	158	21	.	.	.
cord-005941-e4fvj54l	159	1	However	however	RB
cord-005941-e4fvj54l	159	2	,	,	,
cord-005941-e4fvj54l	159	3	the	the	DT
cord-005941-e4fvj54l	159	4	in	in	IN
cord-005941-e4fvj54l	159	5	vivo	vivo	NN
cord-005941-e4fvj54l	159	6	role	role	NN
cord-005941-e4fvj54l	159	7	and	and	CC
cord-005941-e4fvj54l	159	8	importance	importance	NN
cord-005941-e4fvj54l	159	9	of	of	IN
cord-005941-e4fvj54l	159	10	these	these	DT
cord-005941-e4fvj54l	159	11	factors	factor	NNS
cord-005941-e4fvj54l	159	12	is	be	VBZ
cord-005941-e4fvj54l	159	13	not	not	RB
cord-005941-e4fvj54l	159	14	clearly	clearly	RB
cord-005941-e4fvj54l	159	15	determined	determine	VBN
cord-005941-e4fvj54l	159	16	.	.	.
cord-005941-e4fvj54l	160	1	Some	some	DT
cord-005941-e4fvj54l	160	2	of	of	IN
cord-005941-e4fvj54l	160	3	these	these	DT
cord-005941-e4fvj54l	160	4	stimuli	stimulus	NNS
cord-005941-e4fvj54l	160	5	,	,	,
cord-005941-e4fvj54l	160	6	e.g.	e.g.	RB
cord-005941-e4fvj54l	160	7	,	,	,
cord-005941-e4fvj54l	160	8	glucocorticoids	glucocorticoid	NNS
cord-005941-e4fvj54l	160	9	,	,	,
cord-005941-e4fvj54l	160	10	may	may	MD
cord-005941-e4fvj54l	160	11	vary	vary	VB
cord-005941-e4fvj54l	160	12	in	in	IN
cord-005941-e4fvj54l	160	13	their	-PRON-	PRP$
cord-005941-e4fvj54l	160	14	effects	effect	NNS
cord-005941-e4fvj54l	160	15	depending	depend	VBG
cord-005941-e4fvj54l	160	16	on	on	IN
cord-005941-e4fvj54l	160	17	dose	dose	NN
cord-005941-e4fvj54l	160	18	and	and	CC
cord-005941-e4fvj54l	160	19	time	time	NN
cord-005941-e4fvj54l	160	20	[	[	-LRB-
cord-005941-e4fvj54l	160	21	105	105	CD
cord-005941-e4fvj54l	160	22	]	]	-RRB-
cord-005941-e4fvj54l	160	23	,	,	,
cord-005941-e4fvj54l	160	24	and	and	CC
cord-005941-e4fvj54l	160	25	there	there	EX
cord-005941-e4fvj54l	160	26	may	may	MD
cord-005941-e4fvj54l	160	27	be	be	VB
cord-005941-e4fvj54l	160	28	different	different	JJ
cord-005941-e4fvj54l	160	29	pathways	pathway	NNS
cord-005941-e4fvj54l	160	30	for	for	IN
cord-005941-e4fvj54l	160	31	the	the	DT
cord-005941-e4fvj54l	160	32	regulation	regulation	NN
cord-005941-e4fvj54l	160	33	of	of	IN
cord-005941-e4fvj54l	160	34	surfactant	surfactant	NN
cord-005941-e4fvj54l	160	35	phospholipid	phospholipid	NN
cord-005941-e4fvj54l	160	36	and	and	CC
cord-005941-e4fvj54l	160	37	protein	protein	NN
cord-005941-e4fvj54l	160	38	synthesis	synthesis	NN
cord-005941-e4fvj54l	160	39	[	[	-LRB-
cord-005941-e4fvj54l	160	40	56	56	CD
cord-005941-e4fvj54l	160	41	]	]	-RRB-
cord-005941-e4fvj54l	160	42	.	.	.
cord-005941-e4fvj54l	161	1	A	a	DT
cord-005941-e4fvj54l	161	2	recent	recent	JJ
cord-005941-e4fvj54l	161	3	in	in	IN
cord-005941-e4fvj54l	161	4	vivo	vivo	NN
cord-005941-e4fvj54l	161	5	study	study	NN
cord-005941-e4fvj54l	161	6	[	[	-LRB-
cord-005941-e4fvj54l	161	7	42	42	CD
cord-005941-e4fvj54l	161	8	]	]	-RRB-
cord-005941-e4fvj54l	161	9	has	have	VBZ
cord-005941-e4fvj54l	161	10	investigated	investigate	VBN
cord-005941-e4fvj54l	161	11	the	the	DT
cord-005941-e4fvj54l	161	12	influence	influence	NN
cord-005941-e4fvj54l	161	13	of	of	IN
cord-005941-e4fvj54l	161	14	exogenously	exogenously	RB
cord-005941-e4fvj54l	161	15	administered	administer	VBN
cord-005941-e4fvj54l	161	16	glucocorticoids	glucocorticoid	NNS
cord-005941-e4fvj54l	161	17	and	and	CC
cord-005941-e4fvj54l	161	18	of	of	IN
cord-005941-e4fvj54l	161	19	adrenalectomy	adrenalectomy	NN
cord-005941-e4fvj54l	161	20	on	on	IN
cord-005941-e4fvj54l	161	21	the	the	DT
cord-005941-e4fvj54l	161	22	regulation	regulation	NN
cord-005941-e4fvj54l	161	23	of	of	IN
cord-005941-e4fvj54l	161	24	surfactant	surfactant	NN
cord-005941-e4fvj54l	161	25	proteinsl	proteinsl	NNP
cord-005941-e4fvj54l	161	26	Glucocorticoid	Glucocorticoid	NNP
cord-005941-e4fvj54l	161	27	administration	administration	NN
cord-005941-e4fvj54l	161	28	resulted	result	VBD
cord-005941-e4fvj54l	161	29	in	in	IN
cord-005941-e4fvj54l	161	30	the	the	DT
cord-005941-e4fvj54l	161	31	accumulation	accumulation	NN
cord-005941-e4fvj54l	161	32	of	of	IN
cord-005941-e4fvj54l	161	33	mRNAs	mrnas	CD
cord-005941-e4fvj54l	161	34	of	of	IN
cord-005941-e4fvj54l	161	35	surfactant	surfactant	NN
cord-005941-e4fvj54l	161	36	proteins	protein	NNS
cord-005941-e4fvj54l	161	37	SP	SP	NNP
cord-005941-e4fvj54l	161	38	-	-	HYPH
cord-005941-e4fvj54l	161	39	A	A	NNP
cord-005941-e4fvj54l	161	40	,	,	,
cord-005941-e4fvj54l	161	41	B	b	NN
cord-005941-e4fvj54l	161	42	,	,	,
cord-005941-e4fvj54l	161	43	and	and	CC
cord-005941-e4fvj54l	161	44	C	C	NNP
cord-005941-e4fvj54l	161	45	,	,	,
cord-005941-e4fvj54l	161	46	with	with	IN
cord-005941-e4fvj54l	161	47	the	the	DT
cord-005941-e4fvj54l	161	48	highest	high	JJS
cord-005941-e4fvj54l	161	49	response	response	NN
cord-005941-e4fvj54l	161	50	being	be	VBG
cord-005941-e4fvj54l	161	51	SP	SP	NNP
cord-005941-e4fvj54l	161	52	-	-	HYPH
cord-005941-e4fvj54l	161	53	B	B	NNP
cord-005941-e4fvj54l	161	54	mRNA	mrna	NN
cord-005941-e4fvj54l	161	55	.	.	.
cord-005941-e4fvj54l	162	1	However	however	RB
cord-005941-e4fvj54l	162	2	,	,	,
cord-005941-e4fvj54l	162	3	adrenalectomy	adrenalectomy	NNP
cord-005941-e4fvj54l	162	4	did	do	VBD
cord-005941-e4fvj54l	162	5	not	not	RB
cord-005941-e4fvj54l	162	6	change	change	VB
cord-005941-e4fvj54l	162	7	the	the	DT
cord-005941-e4fvj54l	162	8	mRNA	mRNA	NNP
cord-005941-e4fvj54l	162	9	levels	level	NNS
cord-005941-e4fvj54l	162	10	but	but	CC
cord-005941-e4fvj54l	162	11	decreased	decrease	VBD
cord-005941-e4fvj54l	162	12	the	the	DT
cord-005941-e4fvj54l	162	13	total	total	JJ
cord-005941-e4fvj54l	162	14	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	162	15	SP	sp	NN
cord-005941-e4fvj54l	162	16	-	-	HYPH
cord-005941-e4fvj54l	162	17	A	A	NNP
cord-005941-e4fvj54l	162	18	levels	level	NNS
cord-005941-e4fvj54l	162	19	.	.	.
cord-005941-e4fvj54l	163	1	This	this	DT
cord-005941-e4fvj54l	163	2	study	study	NN
cord-005941-e4fvj54l	163	3	demonstrates	demonstrate	VBZ
cord-005941-e4fvj54l	163	4	that	that	IN
cord-005941-e4fvj54l	163	5	exogenous	exogenous	JJ
cord-005941-e4fvj54l	163	6	glucocorticoids	glucocorticoid	NNS
cord-005941-e4fvj54l	163	7	enhance	enhance	VBP
cord-005941-e4fvj54l	163	8	surfactant	surfactant	NN
cord-005941-e4fvj54l	163	9	protein	protein	NN
cord-005941-e4fvj54l	163	10	synthesis	synthesis	NN
cord-005941-e4fvj54l	163	11	and	and	CC
cord-005941-e4fvj54l	163	12	suggests	suggest	VBZ
cord-005941-e4fvj54l	163	13	that	that	IN
cord-005941-e4fvj54l	163	14	adrenal	adrenal	JJ
cord-005941-e4fvj54l	163	15	hormones	hormone	NNS
cord-005941-e4fvj54l	163	16	may	may	MD
cord-005941-e4fvj54l	163	17	have	have	VB
cord-005941-e4fvj54l	163	18	a	a	DT
cord-005941-e4fvj54l	163	19	role	role	NN
cord-005941-e4fvj54l	163	20	in	in	IN
cord-005941-e4fvj54l	163	21	the	the	DT
cord-005941-e4fvj54l	163	22	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	163	23	response	response	NN
cord-005941-e4fvj54l	163	24	to	to	TO
cord-005941-e4fvj54l	163	25	stress	stress	NN
cord-005941-e4fvj54l	163	26	.	.	.
cord-005941-e4fvj54l	164	1	On	on	IN
cord-005941-e4fvj54l	164	2	the	the	DT
cord-005941-e4fvj54l	164	3	other	other	JJ
cord-005941-e4fvj54l	164	4	hand	hand	NN
cord-005941-e4fvj54l	164	5	,	,	,
cord-005941-e4fvj54l	164	6	endogenous	endogenous	JJ
cord-005941-e4fvj54l	164	7	steroids	steroid	NNS
cord-005941-e4fvj54l	164	8	under	under	IN
cord-005941-e4fvj54l	164	9	normal	normal	JJ
cord-005941-e4fvj54l	164	10	conditions	condition	NNS
cord-005941-e4fvj54l	164	11	do	do	VBP
cord-005941-e4fvj54l	164	12	not	not	RB
cord-005941-e4fvj54l	164	13	seem	seem	VB
cord-005941-e4fvj54l	164	14	to	to	TO
cord-005941-e4fvj54l	164	15	be	be	VB
cord-005941-e4fvj54l	164	16	important	important	JJ
cord-005941-e4fvj54l	164	17	to	to	IN
cord-005941-e4fvj54l	164	18	baseline	baseline	JJ
cord-005941-e4fvj54l	164	19	surfactant	surfactant	NN
cord-005941-e4fvj54l	164	20	protein	protein	NN
cord-005941-e4fvj54l	164	21	synthesis	synthesis	NN
cord-005941-e4fvj54l	164	22	at	at	IN
cord-005941-e4fvj54l	164	23	the	the	DT
cord-005941-e4fvj54l	164	24	mRNA	mRNA	NNP
cord-005941-e4fvj54l	164	25	level	level	NN
cord-005941-e4fvj54l	164	26	but	but	CC
cord-005941-e4fvj54l	164	27	may	may	MD
cord-005941-e4fvj54l	164	28	to	to	IN
cord-005941-e4fvj54l	164	29	a	a	DT
cord-005941-e4fvj54l	164	30	minor	minor	JJ
cord-005941-e4fvj54l	164	31	degree	degree	NN
cord-005941-e4fvj54l	164	32	contribute	contribute	VB
cord-005941-e4fvj54l	164	33	to	to	IN
cord-005941-e4fvj54l	164	34	translational	translational	JJ
cord-005941-e4fvj54l	164	35	or	or	CC
cord-005941-e4fvj54l	164	36	posttranslational	posttranslational	JJ
cord-005941-e4fvj54l	164	37	processing	processing	NN
cord-005941-e4fvj54l	164	38	.	.	.
cord-005941-e4fvj54l	165	1	The	the	DT
cord-005941-e4fvj54l	165	2	inhibition	inhibition	NN
cord-005941-e4fvj54l	165	3	of	of	IN
cord-005941-e4fvj54l	165	4	surfactant	surfactant	NN
cord-005941-e4fvj54l	165	5	production	production	NN
cord-005941-e4fvj54l	165	6	is	be	VBZ
cord-005941-e4fvj54l	165	7	possibly	possibly	RB
cord-005941-e4fvj54l	165	8	controlled	control	VBN
cord-005941-e4fvj54l	165	9	by	by	IN
cord-005941-e4fvj54l	165	10	a	a	DT
cord-005941-e4fvj54l	165	11	feedback	feedback	NN
cord-005941-e4fvj54l	165	12	mechanism	mechanism	NN
cord-005941-e4fvj54l	165	13	involving	involve	VBG
cord-005941-e4fvj54l	165	14	a	a	DT
cord-005941-e4fvj54l	165	15	surfactant	surfactant	NN
cord-005941-e4fvj54l	165	16	protein	protein	NN
cord-005941-e4fvj54l	165	17	[	[	-LRB-
cord-005941-e4fvj54l	165	18	172	172	CD
cord-005941-e4fvj54l	165	19	]	]	-RRB-
cord-005941-e4fvj54l	165	20	.	.	.
cord-005941-e4fvj54l	166	1	Surfactant	surfactant	NN
cord-005941-e4fvj54l	166	2	secretion	secretion	NN
cord-005941-e4fvj54l	166	3	into	into	IN
cord-005941-e4fvj54l	166	4	the	the	DT
cord-005941-e4fvj54l	166	5	alveolar	alveolar	JJ
cord-005941-e4fvj54l	166	6	space	space	NN
cord-005941-e4fvj54l	166	7	is	be	VBZ
cord-005941-e4fvj54l	166	8	accomplished	accomplish	VBN
cord-005941-e4fvj54l	166	9	by	by	IN
cord-005941-e4fvj54l	166	10	exocytosis	exocytosis	NN
cord-005941-e4fvj54l	166	11	of	of	IN
cord-005941-e4fvj54l	166	12	the	the	DT
cord-005941-e4fvj54l	166	13	lamellar	lamellar	JJ
cord-005941-e4fvj54l	166	14	bodies	body	NNS
cord-005941-e4fvj54l	166	15	.	.	.
cord-005941-e4fvj54l	167	1	Experimental	experimental	JJ
cord-005941-e4fvj54l	167	2	data	datum	NNS
cord-005941-e4fvj54l	167	3	suggest	suggest	VBP
cord-005941-e4fvj54l	167	4	that	that	IN
cord-005941-e4fvj54l	167	5	various	various	JJ
cord-005941-e4fvj54l	167	6	stimuli	stimulus	NNS
cord-005941-e4fvj54l	167	7	like	like	IN
cord-005941-e4fvj54l	167	8	high	high	JJ
cord-005941-e4fvj54l	167	9	volume	volume	NN
cord-005941-e4fvj54l	167	10	lung	lung	NN
cord-005941-e4fvj54l	167	11	inflation	inflation	NN
cord-005941-e4fvj54l	167	12	and	and	CC
cord-005941-e4fvj54l	167	13	increased	increase	VBN
cord-005941-e4fvj54l	167	14	ventilation	ventilation	NN
cord-005941-e4fvj54l	167	15	rate	rate	NN
cord-005941-e4fvj54l	167	16	,	,	,
cord-005941-e4fvj54l	167	17	adrenergic	adrenergic	JJ
cord-005941-e4fvj54l	167	18	agents	agent	NNS
cord-005941-e4fvj54l	167	19	,	,	,
cord-005941-e4fvj54l	167	20	estrogens	estrogen	NNS
cord-005941-e4fvj54l	167	21	,	,	,
cord-005941-e4fvj54l	167	22	and	and	CC
cord-005941-e4fvj54l	167	23	thyroid	thyroid	JJ
cord-005941-e4fvj54l	167	24	hormones	hormone	NNS
cord-005941-e4fvj54l	167	25	may	may	MD
cord-005941-e4fvj54l	167	26	enhance	enhance	VB
cord-005941-e4fvj54l	167	27	surfactant	surfactant	NN
cord-005941-e4fvj54l	167	28	secretion	secretion	NN
cord-005941-e4fvj54l	167	29	,	,	,
cord-005941-e4fvj54l	167	30	while	while	IN
cord-005941-e4fvj54l	167	31	beta	beta	NN
cord-005941-e4fvj54l	167	32	-	-	HYPH
cord-005941-e4fvj54l	167	33	blockade	blockade	NN
cord-005941-e4fvj54l	167	34	and	and	CC
cord-005941-e4fvj54l	167	35	an	an	DT
cord-005941-e4fvj54l	167	36	SP	SP	NNP
cord-005941-e4fvj54l	167	37	-	-	HYPH
cord-005941-e4fvj54l	167	38	A	a	NN
cord-005941-e4fvj54l	167	39	-	-	HYPH
cord-005941-e4fvj54l	167	40	dependent	dependent	JJ
cord-005941-e4fvj54l	167	41	feedback	feedback	NN
cord-005941-e4fvj54l	167	42	mechanism	mechanism	NN
cord-005941-e4fvj54l	167	43	have	have	VBP
cord-005941-e4fvj54l	167	44	inhibitory	inhibitory	JJ
cord-005941-e4fvj54l	167	45	effects	effect	NNS
cord-005941-e4fvj54l	167	46	[	[	-LRB-
cord-005941-e4fvj54l	167	47	18	18	CD
cord-005941-e4fvj54l	167	48	,	,	,
cord-005941-e4fvj54l	167	49	33	33	CD
cord-005941-e4fvj54l	167	50	,	,	,
cord-005941-e4fvj54l	167	51	65	65	CD
cord-005941-e4fvj54l	167	52	]	]	-RRB-
cord-005941-e4fvj54l	168	1	(	(	-LRB-
cord-005941-e4fvj54l	168	2	Table	table	NN
cord-005941-e4fvj54l	168	3	2	2	CD
cord-005941-e4fvj54l	168	4	)	)	-RRB-
cord-005941-e4fvj54l	168	5	.	.	.
cord-005941-e4fvj54l	169	1	SP	SP	NNP
cord-005941-e4fvj54l	169	2	-	-	HYPH
cord-005941-e4fvj54l	169	3	D	D	NNP
cord-005941-e4fvj54l	169	4	seems	seem	VBZ
cord-005941-e4fvj54l	169	5	to	to	TO
cord-005941-e4fvj54l	169	6	counteract	counteract	VB
cord-005941-e4fvj54l	169	7	the	the	DT
cord-005941-e4fvj54l	169	8	inhibitory	inhibitory	JJ
cord-005941-e4fvj54l	169	9	effect	effect	NN
cord-005941-e4fvj54l	169	10	of	of	IN
cord-005941-e4fvj54l	169	11	SP	SP	NNP
cord-005941-e4fvj54l	169	12	-	-	HYPH
cord-005941-e4fvj54l	169	13	A	A	NNP
cord-005941-e4fvj54l	169	14	[	[	-LRB-
cord-005941-e4fvj54l	169	15	98	98	CD
cord-005941-e4fvj54l	169	16	]	]	-RRB-
cord-005941-e4fvj54l	169	17	.	.	.
cord-005941-e4fvj54l	170	1	Again	again	RB
cord-005941-e4fvj54l	170	2	,	,	,
cord-005941-e4fvj54l	170	3	the	the	DT
cord-005941-e4fvj54l	170	4	in	in	IN
cord-005941-e4fvj54l	170	5	vivo	vivo	NN
cord-005941-e4fvj54l	170	6	significance	significance	NN
cord-005941-e4fvj54l	170	7	of	of	IN
cord-005941-e4fvj54l	170	8	these	these	DT
cord-005941-e4fvj54l	170	9	experimental	experimental	JJ
cord-005941-e4fvj54l	170	10	data	data	NN
cord-005941-e4fvj54l	170	11	remains	remain	VBZ
cord-005941-e4fvj54l	170	12	under	under	IN
cord-005941-e4fvj54l	170	13	discussion	discussion	NN
cord-005941-e4fvj54l	170	14	.	.	.
cord-005941-e4fvj54l	171	1	Turnover	turnover	NN
cord-005941-e4fvj54l	171	2	studies	study	NNS
cord-005941-e4fvj54l	171	3	with	with	IN
cord-005941-e4fvj54l	171	4	different	different	JJ
cord-005941-e4fvj54l	171	5	labeled	label	VBN
cord-005941-e4fvj54l	171	6	surfacrant	surfacrant	JJ
cord-005941-e4fvj54l	171	7	phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	171	8	after	after	IN
cord-005941-e4fvj54l	171	9	secretion	secretion	NN
cord-005941-e4fvj54l	171	10	have	have	VBP
cord-005941-e4fvj54l	171	11	demonstrated	demonstrate	VBN
cord-005941-e4fvj54l	171	12	half	half	RB
cord-005941-e4fvj54l	171	13	-	-	HYPH
cord-005941-e4fvj54l	171	14	lives	life	NNS
cord-005941-e4fvj54l	171	15	of	of	IN
cord-005941-e4fvj54l	171	16	between	between	IN
cord-005941-e4fvj54l	171	17	15	15	CD
cord-005941-e4fvj54l	171	18	and	and	CC
cord-005941-e4fvj54l	171	19	30	30	CD
cord-005941-e4fvj54l	171	20	h	h	NN
cord-005941-e4fvj54l	171	21	[	[	-LRB-
cord-005941-e4fvj54l	171	22	60	60	CD
cord-005941-e4fvj54l	171	23	,	,	,
cord-005941-e4fvj54l	171	24	155	155	CD
cord-005941-e4fvj54l	171	25	]	]	-RRB-
cord-005941-e4fvj54l	171	26	.	.	.
cord-005941-e4fvj54l	172	1	The	the	DT
cord-005941-e4fvj54l	172	2	fate	fate	NN
cord-005941-e4fvj54l	172	3	of	of	IN
cord-005941-e4fvj54l	172	4	secreted	secrete	VBN
cord-005941-e4fvj54l	172	5	surfactant	surfactant	NN
cord-005941-e4fvj54l	172	6	material	material	NN
cord-005941-e4fvj54l	172	7	seems	seem	VBZ
cord-005941-e4fvj54l	172	8	to	to	TO
cord-005941-e4fvj54l	172	9	be	be	VB
cord-005941-e4fvj54l	172	10	determined	determine	VBN
cord-005941-e4fvj54l	172	11	by	by	IN
cord-005941-e4fvj54l	172	12	five	five	CD
cord-005941-e4fvj54l	172	13	mechanisms	mechanism	NNS
cord-005941-e4fvj54l	172	14	:	:	:
cord-005941-e4fvj54l	173	1	-Intraalveolar	-Intraalveolar	.
cord-005941-e4fvj54l	174	1	catabolism	catabolism	NN
cord-005941-e4fvj54l	174	2	-Phagocytosis	-phagocytosis	NN
cord-005941-e4fvj54l	174	3	and	and	CC
cord-005941-e4fvj54l	174	4	degradation	degradation	NN
cord-005941-e4fvj54l	174	5	by	by	IN
cord-005941-e4fvj54l	174	6	alveolar	alveolar	JJ
cord-005941-e4fvj54l	174	7	macrophages	macrophage	NNS
cord-005941-e4fvj54l	174	8	[	[	-LRB-
cord-005941-e4fvj54l	174	9	110	110	CD
cord-005941-e4fvj54l	174	10	,	,	,
cord-005941-e4fvj54l	174	11	118	118	CD
cord-005941-e4fvj54l	174	12	]	]	-RRB-
cord-005941-e4fvj54l	175	1	-Removal	-removal	WP
cord-005941-e4fvj54l	175	2	by	by	IN
cord-005941-e4fvj54l	175	3	the	the	DT
cord-005941-e4fvj54l	175	4	mucociliary	mucociliary	JJ
cord-005941-e4fvj54l	175	5	escalator	escalator	NNP
cord-005941-e4fvj54l	175	6	-Recycling	-recycle	VBG
cord-005941-e4fvj54l	175	7	into	into	IN
cord-005941-e4fvj54l	175	8	the	the	DT
cord-005941-e4fvj54l	175	9	alveolar	alveolar	JJ
cord-005941-e4fvj54l	175	10	type	type	NN
cord-005941-e4fvj54l	175	11	II	II	NNP
cord-005941-e4fvj54l	175	12	cell	cell	NN
cord-005941-e4fvj54l	175	13	-Redistribution	-redistribution	NN
cord-005941-e4fvj54l	175	14	into	into	IN
cord-005941-e4fvj54l	175	15	other	other	JJ
cord-005941-e4fvj54l	175	16	surrounding	surround	VBG
cord-005941-e4fvj54l	175	17	tissue	tissue	NN
cord-005941-e4fvj54l	175	18	Clearance	clearance	NN
cord-005941-e4fvj54l	175	19	studies	study	NNS
cord-005941-e4fvj54l	175	20	in	in	IN
cord-005941-e4fvj54l	175	21	rabbits	rabbit	NNS
cord-005941-e4fvj54l	175	22	[	[	-LRB-
cord-005941-e4fvj54l	175	23	140	140	CD
cord-005941-e4fvj54l	175	24	]	]	-RRB-
cord-005941-e4fvj54l	175	25	have	have	VBP
cord-005941-e4fvj54l	175	26	shown	show	VBN
cord-005941-e4fvj54l	175	27	that	that	IN
cord-005941-e4fvj54l	175	28	approximately	approximately	RB
cord-005941-e4fvj54l	175	29	7	7	CD
cord-005941-e4fvj54l	175	30	%	%	NN
cord-005941-e4fvj54l	175	31	of	of	IN
cord-005941-e4fvj54l	175	32	radiolabeled	radiolabeled	JJ
cord-005941-e4fvj54l	175	33	phosphatidylcholine	phosphatidylcholine	NN
cord-005941-e4fvj54l	175	34	is	be	VBZ
cord-005941-e4fvj54l	175	35	removed	remove	VBN
cord-005941-e4fvj54l	175	36	via	via	IN
cord-005941-e4fvj54l	175	37	the	the	DT
cord-005941-e4fvj54l	175	38	upper	upper	JJ
cord-005941-e4fvj54l	175	39	airways	airways	NNPS
cord-005941-e4fvj54l	175	40	in	in	IN
cord-005941-e4fvj54l	175	41	24	24	CD
cord-005941-e4fvj54l	175	42	h	h	NNP
cord-005941-e4fvj54l	175	43	,	,	,
cord-005941-e4fvj54l	175	44	suggesting	suggest	VBG
cord-005941-e4fvj54l	175	45	that	that	IN
cord-005941-e4fvj54l	175	46	this	this	DT
cord-005941-e4fvj54l	175	47	pathway	pathway	NN
cord-005941-e4fvj54l	175	48	is	be	VBZ
cord-005941-e4fvj54l	175	49	only	only	RB
cord-005941-e4fvj54l	175	50	of	of	IN
cord-005941-e4fvj54l	175	51	minor	minor	JJ
cord-005941-e4fvj54l	175	52	importance	importance	NN
cord-005941-e4fvj54l	175	53	.	.	.
cord-005941-e4fvj54l	176	1	Further	further	JJ
cord-005941-e4fvj54l	176	2	work	work	NN
cord-005941-e4fvj54l	176	3	by	by	IN
cord-005941-e4fvj54l	176	4	the	the	DT
cord-005941-e4fvj54l	176	5	same	same	JJ
cord-005941-e4fvj54l	176	6	group	group	NN
cord-005941-e4fvj54l	176	7	[	[	-LRB-
cord-005941-e4fvj54l	176	8	139	139	CD
cord-005941-e4fvj54l	176	9	]	]	-RRB-
cord-005941-e4fvj54l	176	10	supports	support	VBZ
cord-005941-e4fvj54l	176	11	evidence	evidence	NN
cord-005941-e4fvj54l	176	12	that	that	IN
cord-005941-e4fvj54l	176	13	most	most	JJS
cord-005941-e4fvj54l	176	14	surfactant	surfactant	NN
cord-005941-e4fvj54l	176	15	material	material	NN
cord-005941-e4fvj54l	176	16	is	be	VBZ
cord-005941-e4fvj54l	176	17	probably	probably	RB
cord-005941-e4fvj54l	176	18	redistributed	redistribute	VBN
cord-005941-e4fvj54l	176	19	into	into	IN
cord-005941-e4fvj54l	176	20	the	the	DT
cord-005941-e4fvj54l	176	21	surrounding	surround	VBG
cord-005941-e4fvj54l	176	22	tissue	tissue	NN
cord-005941-e4fvj54l	176	23	or	or	CC
cord-005941-e4fvj54l	176	24	is	be	VBZ
cord-005941-e4fvj54l	176	25	recycled	recycle	VBN
cord-005941-e4fvj54l	176	26	into	into	IN
cord-005941-e4fvj54l	176	27	alveolar	alveolar	JJ
cord-005941-e4fvj54l	176	28	type	type	NN
cord-005941-e4fvj54l	176	29	II	ii	CD
cord-005941-e4fvj54l	176	30	cells	cell	NNS
cord-005941-e4fvj54l	176	31	.	.	.
cord-005941-e4fvj54l	177	1	Many	many	JJ
cord-005941-e4fvj54l	177	2	aspects	aspect	NNS
cord-005941-e4fvj54l	177	3	of	of	IN
cord-005941-e4fvj54l	177	4	the	the	DT
cord-005941-e4fvj54l	177	5	regulation	regulation	NN
cord-005941-e4fvj54l	177	6	of	of	IN
cord-005941-e4fvj54l	177	7	these	these	DT
cord-005941-e4fvj54l	177	8	processes	process	NNS
cord-005941-e4fvj54l	177	9	remain	remain	VBP
cord-005941-e4fvj54l	177	10	to	to	TO
cord-005941-e4fvj54l	177	11	be	be	VB
cord-005941-e4fvj54l	177	12	clarified	clarify	VBN
cord-005941-e4fvj54l	177	13	.	.	.
cord-005941-e4fvj54l	178	1	SP	SP	NNP
cord-005941-e4fvj54l	178	2	-	-	HYPH
cord-005941-e4fvj54l	178	3	A	A	NNP
cord-005941-e4fvj54l	178	4	has	have	VBZ
cord-005941-e4fvj54l	178	5	been	be	VBN
cord-005941-e4fvj54l	178	6	shown	show	VBN
cord-005941-e4fvj54l	178	7	to	to	TO
cord-005941-e4fvj54l	178	8	enhance	enhance	VB
cord-005941-e4fvj54l	178	9	the	the	DT
cord-005941-e4fvj54l	178	10	uptake	uptake	NN
cord-005941-e4fvj54l	178	11	of	of	IN
cord-005941-e4fvj54l	178	12	liposomes	liposome	NNS
cord-005941-e4fvj54l	178	13	into	into	IN
cord-005941-e4fvj54l	178	14	the	the	DT
cord-005941-e4fvj54l	178	15	alveolar	alveolar	JJ
cord-005941-e4fvj54l	178	16	type	type	NN
cord-005941-e4fvj54l	178	17	II	ii	CD
cord-005941-e4fvj54l	178	18	cell	cell	NN
cord-005941-e4fvj54l	178	19	[	[	-LRB-
cord-005941-e4fvj54l	178	20	198	198	CD
cord-005941-e4fvj54l	178	21	]	]	-RRB-
cord-005941-e4fvj54l	178	22	.	.	.
cord-005941-e4fvj54l	179	1	This	this	DT
cord-005941-e4fvj54l	179	2	process	process	NN
cord-005941-e4fvj54l	179	3	is	be	VBZ
cord-005941-e4fvj54l	179	4	probably	probably	RB
cord-005941-e4fvj54l	179	5	mediated	mediate	VBN
cord-005941-e4fvj54l	179	6	by	by	IN
cord-005941-e4fvj54l	179	7	an	an	DT
cord-005941-e4fvj54l	179	8	SP	SP	NNP
cord-005941-e4fvj54l	179	9	-	-	HYPH
cord-005941-e4fvj54l	179	10	A	a	DT
cord-005941-e4fvj54l	179	11	receptor	receptor	NN
cord-005941-e4fvj54l	179	12	on	on	IN
cord-005941-e4fvj54l	179	13	the	the	DT
cord-005941-e4fvj54l	179	14	epithelial	epithelial	JJ
cord-005941-e4fvj54l	179	15	surface	surface	NN
cord-005941-e4fvj54l	179	16	of	of	IN
cord-005941-e4fvj54l	179	17	type	type	NN
cord-005941-e4fvj54l	179	18	II	ii	CD
cord-005941-e4fvj54l	179	19	cells	cell	NNS
cord-005941-e4fvj54l	179	20	,	,	,
cord-005941-e4fvj54l	179	21	which	which	WDT
cord-005941-e4fvj54l	179	22	also	also	RB
cord-005941-e4fvj54l	179	23	controls	control	VBZ
cord-005941-e4fvj54l	179	24	the	the	DT
cord-005941-e4fvj54l	179	25	reuptake	reuptake	NN
cord-005941-e4fvj54l	179	26	of	of	IN
cord-005941-e4fvj54l	179	27	SP	SP	NNP
cord-005941-e4fvj54l	179	28	-	-	HYPH
cord-005941-e4fvj54l	179	29	A	A	NNP
cord-005941-e4fvj54l	179	30	[	[	-LRB-
cord-005941-e4fvj54l	179	31	157	157	CD
cord-005941-e4fvj54l	179	32	]	]	-RRB-
cord-005941-e4fvj54l	179	33	.	.	.
cord-005941-e4fvj54l	180	1	S	S	NNP
cord-005941-e4fvj54l	181	1	u	u	NNP
cord-005941-e4fvj54l	181	2	r	r	NNP
cord-005941-e4fvj54l	181	3	f	f	NNP
cord-005941-e4fvj54l	181	4	a	a	DT
cord-005941-e4fvj54l	181	5	c	c	NN
cord-005941-e4fvj54l	181	6	t	t	NN
cord-005941-e4fvj54l	181	7	a	a	NN
cord-005941-e4fvj54l	181	8	n	n	NN
cord-005941-e4fvj54l	181	9	t	t	NNP
cord-005941-e4fvj54l	181	10	a	a	DT
cord-005941-e4fvj54l	181	11	n	n	NN
cord-005941-e4fvj54l	181	12	d	d	NNP
cord-005941-e4fvj54l	181	13	l	l	NN
cord-005941-e4fvj54l	181	14	u	u	NN
cord-005941-e4fvj54l	181	15	n	n	NN
cord-005941-e4fvj54l	181	16	g	g	NN
cord-005941-e4fvj54l	181	17	f	f	NN
cord-005941-e4fvj54l	181	18	u	u	NNP
cord-005941-e4fvj54l	181	19	n	n	NN
cord-005941-e4fvj54l	181	20	c	c	NN
cord-005941-e4fvj54l	181	21	t	t	NN
cord-005941-e4fvj54l	182	1	i	i	PRP
cord-005941-e4fvj54l	183	1	o	o	UH
cord-005941-e4fvj54l	183	2	n	n	NN
cord-005941-e4fvj54l	184	1	This	this	DT
cord-005941-e4fvj54l	184	2	review	review	NN
cord-005941-e4fvj54l	184	3	will	will	MD
cord-005941-e4fvj54l	184	4	only	only	RB
cord-005941-e4fvj54l	184	5	give	give	VB
cord-005941-e4fvj54l	184	6	a	a	DT
cord-005941-e4fvj54l	184	7	short	short	JJ
cord-005941-e4fvj54l	184	8	introduction	introduction	NN
cord-005941-e4fvj54l	184	9	into	into	IN
cord-005941-e4fvj54l	184	10	the	the	DT
cord-005941-e4fvj54l	184	11	role	role	NN
cord-005941-e4fvj54l	184	12	of	of	IN
cord-005941-e4fvj54l	184	13	surfactant	surfactant	NN
cord-005941-e4fvj54l	184	14	in	in	IN
cord-005941-e4fvj54l	184	15	alveolar	alveolar	JJ
cord-005941-e4fvj54l	184	16	stability	stability	NN
cord-005941-e4fvj54l	184	17	and	and	CC
cord-005941-e4fvj54l	184	18	in	in	IN
cord-005941-e4fvj54l	184	19	the	the	DT
cord-005941-e4fvj54l	184	20	work	work	NN
cord-005941-e4fvj54l	184	21	of	of	IN
cord-005941-e4fvj54l	184	22	breathing	breathing	NN
cord-005941-e4fvj54l	184	23	.	.	.
cord-005941-e4fvj54l	185	1	The	the	DT
cord-005941-e4fvj54l	185	2	interested	interested	JJ
cord-005941-e4fvj54l	185	3	reader	reader	NN
cord-005941-e4fvj54l	185	4	is	be	VBZ
cord-005941-e4fvj54l	185	5	referred	refer	VBN
cord-005941-e4fvj54l	185	6	to	to	IN
cord-005941-e4fvj54l	185	7	a	a	DT
cord-005941-e4fvj54l	185	8	number	number	NN
cord-005941-e4fvj54l	185	9	of	of	IN
cord-005941-e4fvj54l	185	10	articles	article	NNS
cord-005941-e4fvj54l	185	11	[	[	-LRB-
cord-005941-e4fvj54l	185	12	22	22	CD
cord-005941-e4fvj54l	185	13	,	,	,
cord-005941-e4fvj54l	185	14	69	69	CD
cord-005941-e4fvj54l	185	15	,	,	,
cord-005941-e4fvj54l	185	16	70	70	CD
cord-005941-e4fvj54l	185	17	,	,	,
cord-005941-e4fvj54l	185	18	136	136	CD
cord-005941-e4fvj54l	185	19	,	,	,
cord-005941-e4fvj54l	185	20	194	194	CD
cord-005941-e4fvj54l	185	21	]	]	-RRB-
cord-005941-e4fvj54l	185	22	which	which	WDT
cord-005941-e4fvj54l	185	23	discuss	discuss	VBP
cord-005941-e4fvj54l	185	24	these	these	DT
cord-005941-e4fvj54l	185	25	aspects	aspect	NNS
cord-005941-e4fvj54l	185	26	in	in	IN
cord-005941-e4fvj54l	185	27	detail	detail	NN
cord-005941-e4fvj54l	185	28	.	.	.
cord-005941-e4fvj54l	186	1	The	the	DT
cord-005941-e4fvj54l	186	2	lowering	lowering	NN
cord-005941-e4fvj54l	186	3	of	of	IN
cord-005941-e4fvj54l	186	4	surface	surface	NN
cord-005941-e4fvj54l	186	5	tension	tension	NN
cord-005941-e4fvj54l	186	6	is	be	VBZ
cord-005941-e4fvj54l	186	7	the	the	DT
cord-005941-e4fvj54l	186	8	best	well	RBS
cord-005941-e4fvj54l	186	9	known	know	VBN
cord-005941-e4fvj54l	186	10	function	function	NN
cord-005941-e4fvj54l	186	11	of	of	IN
cord-005941-e4fvj54l	186	12	surfactant	surfactant	NN
cord-005941-e4fvj54l	186	13	material	material	NN
cord-005941-e4fvj54l	186	14	and	and	CC
cord-005941-e4fvj54l	186	15	led	lead	VBD
cord-005941-e4fvj54l	186	16	to	to	IN
cord-005941-e4fvj54l	186	17	its	-PRON-	PRP$
cord-005941-e4fvj54l	186	18	discovery	discovery	NN
cord-005941-e4fvj54l	186	19	.	.	.
cord-005941-e4fvj54l	187	1	However	however	RB
cord-005941-e4fvj54l	187	2	,	,	,
cord-005941-e4fvj54l	187	3	this	this	DT
cord-005941-e4fvj54l	187	4	classical	classical	JJ
cord-005941-e4fvj54l	187	5	surfactant	surfactant	NN
cord-005941-e4fvj54l	187	6	function	function	NN
cord-005941-e4fvj54l	187	7	probably	probably	RB
cord-005941-e4fvj54l	187	8	was	be	VBD
cord-005941-e4fvj54l	187	9	not	not	RB
cord-005941-e4fvj54l	187	10	the	the	DT
cord-005941-e4fvj54l	187	11	initial	initial	JJ
cord-005941-e4fvj54l	187	12	reason	reason	NN
cord-005941-e4fvj54l	187	13	for	for	IN
cord-005941-e4fvj54l	187	14	the	the	DT
cord-005941-e4fvj54l	187	15	development	development	NN
cord-005941-e4fvj54l	187	16	of	of	IN
cord-005941-e4fvj54l	187	17	this	this	DT
cord-005941-e4fvj54l	187	18	material	material	NN
cord-005941-e4fvj54l	187	19	in	in	IN
cord-005941-e4fvj54l	187	20	evolution	evolution	NN
cord-005941-e4fvj54l	187	21	since	since	IN
cord-005941-e4fvj54l	187	22	animals	animal	NNS
cord-005941-e4fvj54l	187	23	with	with	IN
cord-005941-e4fvj54l	187	24	less	less	RBR
cord-005941-e4fvj54l	187	25	complex	complex	JJ
cord-005941-e4fvj54l	187	26	lung	lung	NN
cord-005941-e4fvj54l	187	27	architectures	architecture	NNS
cord-005941-e4fvj54l	187	28	and	and	CC
cord-005941-e4fvj54l	187	29	thus	thus	RB
cord-005941-e4fvj54l	187	30	without	without	IN
cord-005941-e4fvj54l	187	31	a	a	DT
cord-005941-e4fvj54l	187	32	need	need	NN
cord-005941-e4fvj54l	187	33	for	for	IN
cord-005941-e4fvj54l	187	34	surface	surface	NN
cord-005941-e4fvj54l	187	35	-	-	HYPH
cord-005941-e4fvj54l	187	36	tension	tension	NN
cord-005941-e4fvj54l	187	37	lowering	lower	VBG
cord-005941-e4fvj54l	187	38	agents	agent	NNS
cord-005941-e4fvj54l	187	39	already	already	RB
cord-005941-e4fvj54l	187	40	possess	possess	VBP
cord-005941-e4fvj54l	187	41	a	a	DT
cord-005941-e4fvj54l	187	42	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	187	43	surfactant	surfactant	NN
cord-005941-e4fvj54l	187	44	system	system	NN
cord-005941-e4fvj54l	187	45	[	[	-LRB-
cord-005941-e4fvj54l	187	46	52	52	CD
cord-005941-e4fvj54l	187	47	]	]	-RRB-
cord-005941-e4fvj54l	187	48	.	.	.
cord-005941-e4fvj54l	188	1	Surfactant	surfactant	NN
cord-005941-e4fvj54l	188	2	material	material	NN
cord-005941-e4fvj54l	188	3	has	have	VBZ
cord-005941-e4fvj54l	188	4	been	be	VBN
cord-005941-e4fvj54l	188	5	shown	show	VBN
cord-005941-e4fvj54l	188	6	to	to	TO
cord-005941-e4fvj54l	188	7	reduce	reduce	VB
cord-005941-e4fvj54l	188	8	the	the	DT
cord-005941-e4fvj54l	188	9	surface	surface	NN
cord-005941-e4fvj54l	188	10	tension	tension	NN
cord-005941-e4fvj54l	188	11	at	at	IN
cord-005941-e4fvj54l	188	12	the	the	DT
cord-005941-e4fvj54l	188	13	alveolar	alveolar	JJ
cord-005941-e4fvj54l	188	14	air	air	NN
cord-005941-e4fvj54l	188	15	-	-	HYPH
cord-005941-e4fvj54l	188	16	liquid	liquid	NN
cord-005941-e4fvj54l	188	17	interface	interface	NN
cord-005941-e4fvj54l	188	18	down	down	IN
cord-005941-e4fvj54l	188	19	to	to	IN
cord-005941-e4fvj54l	188	20	levels	level	NNS
cord-005941-e4fvj54l	188	21	that	that	WDT
cord-005941-e4fvj54l	188	22	are	be	VBP
cord-005941-e4fvj54l	188	23	required	require	VBN
cord-005941-e4fvj54l	188	24	for	for	IN
cord-005941-e4fvj54l	188	25	normal	normal	JJ
cord-005941-e4fvj54l	188	26	ventilation	ventilation	NN
cord-005941-e4fvj54l	188	27	of	of	IN
cord-005941-e4fvj54l	188	28	the	the	DT
cord-005941-e4fvj54l	188	29	peripheral	peripheral	JJ
cord-005941-e4fvj54l	188	30	lung	lung	NN
cord-005941-e4fvj54l	188	31	.	.	.
cord-005941-e4fvj54l	189	1	It	-PRON-	PRP
cord-005941-e4fvj54l	189	2	reduces	reduce	VBZ
cord-005941-e4fvj54l	189	3	the	the	DT
cord-005941-e4fvj54l	189	4	respiratory	respiratory	JJ
cord-005941-e4fvj54l	189	5	work	work	NN
cord-005941-e4fvj54l	189	6	load	load	NN
cord-005941-e4fvj54l	189	7	throughout	throughout	IN
cord-005941-e4fvj54l	189	8	the	the	DT
cord-005941-e4fvj54l	189	9	respiratory	respiratory	JJ
cord-005941-e4fvj54l	189	10	cycle	cycle	NN
cord-005941-e4fvj54l	189	11	and	and	CC
cord-005941-e4fvj54l	189	12	improves	improve	VBZ
cord-005941-e4fvj54l	189	13	lung	lung	NN
cord-005941-e4fvj54l	189	14	compliance	compliance	NN
cord-005941-e4fvj54l	189	15	.	.	.
cord-005941-e4fvj54l	190	1	The	the	DT
cord-005941-e4fvj54l	190	2	most	most	RBS
cord-005941-e4fvj54l	190	3	important	important	JJ
cord-005941-e4fvj54l	190	4	surfactant	surfactant	NN
cord-005941-e4fvj54l	190	5	component	component	NN
cord-005941-e4fvj54l	190	6	in	in	IN
cord-005941-e4fvj54l	190	7	this	this	DT
cord-005941-e4fvj54l	190	8	regard	regard	NN
cord-005941-e4fvj54l	190	9	is	be	VBZ
cord-005941-e4fvj54l	190	10	saturated	saturate	VBN
cord-005941-e4fvj54l	190	11	phosphatidylcholine	phosphatidylcholine	NN
cord-005941-e4fvj54l	190	12	.	.	.
cord-005941-e4fvj54l	191	1	Other	other	JJ
cord-005941-e4fvj54l	191	2	surfactant	surfactant	NN
cord-005941-e4fvj54l	191	3	components	component	NNS
cord-005941-e4fvj54l	191	4	like	like	IN
cord-005941-e4fvj54l	191	5	SP	SP	NNP
cord-005941-e4fvj54l	191	6	-	-	HYPH
cord-005941-e4fvj54l	191	7	A	A	NNP
cord-005941-e4fvj54l	191	8	and	and	CC
cord-005941-e4fvj54l	191	9	more	more	RBR
cord-005941-e4fvj54l	191	10	importantly	importantly	RB
cord-005941-e4fvj54l	191	11	,	,	,
cord-005941-e4fvj54l	191	12	SP	SP	NNP
cord-005941-e4fvj54l	191	13	-	-	HYPH
cord-005941-e4fvj54l	191	14	B	B	NNP
cord-005941-e4fvj54l	191	15	and	and	CC
cord-005941-e4fvj54l	191	16	SP	SP	NNP
cord-005941-e4fvj54l	191	17	-	-	HYPH
cord-005941-e4fvj54l	191	18	C	C	NNP
cord-005941-e4fvj54l	191	19	,	,	,
cord-005941-e4fvj54l	191	20	have	have	VBP
cord-005941-e4fvj54l	191	21	been	be	VBN
cord-005941-e4fvj54l	191	22	described	describe	VBN
cord-005941-e4fvj54l	191	23	to	to	TO
cord-005941-e4fvj54l	191	24	enhance	enhance	VB
cord-005941-e4fvj54l	191	25	the	the	DT
cord-005941-e4fvj54l	191	26	surface	surface	NN
cord-005941-e4fvj54l	191	27	activity	activity	NN
cord-005941-e4fvj54l	191	28	of	of	IN
cord-005941-e4fvj54l	191	29	this	this	DT
cord-005941-e4fvj54l	191	30	phospholipid	phospholipid	NN
cord-005941-e4fvj54l	191	31	.	.	.
cord-005941-e4fvj54l	192	1	The	the	DT
cord-005941-e4fvj54l	192	2	hydrophobic	hydrophobic	JJ
cord-005941-e4fvj54l	192	3	saturated	saturated	JJ
cord-005941-e4fvj54l	192	4	fatty	fatty	JJ
cord-005941-e4fvj54l	192	5	acids	acid	NNS
cord-005941-e4fvj54l	192	6	of	of	IN
cord-005941-e4fvj54l	192	7	saturated	saturated	JJ
cord-005941-e4fvj54l	192	8	phosphatidylcholine	phosphatidylcholine	NN
cord-005941-e4fvj54l	192	9	are	be	VBP
cord-005941-e4fvj54l	192	10	aligned	align	VBN
cord-005941-e4fvj54l	192	11	in	in	IN
cord-005941-e4fvj54l	192	12	parallel	parallel	NN
cord-005941-e4fvj54l	192	13	and	and	CC
cord-005941-e4fvj54l	192	14	rise	rise	VB
cord-005941-e4fvj54l	192	15	out	out	IN
cord-005941-e4fvj54l	192	16	of	of	IN
cord-005941-e4fvj54l	192	17	the	the	DT
cord-005941-e4fvj54l	192	18	liquid	liquid	JJ
cord-005941-e4fvj54l	192	19	phase	phase	NN
cord-005941-e4fvj54l	192	20	into	into	IN
cord-005941-e4fvj54l	192	21	the	the	DT
cord-005941-e4fvj54l	192	22	alveolar	alveolar	JJ
cord-005941-e4fvj54l	192	23	air	air	NN
cord-005941-e4fvj54l	192	24	.	.	.
cord-005941-e4fvj54l	193	1	The	the	DT
cord-005941-e4fvj54l	193	2	hydrophilic	hydrophilic	JJ
cord-005941-e4fvj54l	193	3	choline	choline	NN
cord-005941-e4fvj54l	193	4	residues	residue	NNS
cord-005941-e4fvj54l	193	5	are	be	VBP
cord-005941-e4fvj54l	193	6	packed	pack	VBN
cord-005941-e4fvj54l	193	7	in	in	IN
cord-005941-e4fvj54l	193	8	the	the	DT
cord-005941-e4fvj54l	193	9	aqueous	aqueous	JJ
cord-005941-e4fvj54l	193	10	phase	phase	NN
cord-005941-e4fvj54l	193	11	of	of	IN
cord-005941-e4fvj54l	193	12	the	the	DT
cord-005941-e4fvj54l	193	13	alveolus	alveolus	NN
cord-005941-e4fvj54l	193	14	.	.	.
cord-005941-e4fvj54l	194	1	This	this	DT
cord-005941-e4fvj54l	194	2	arrangement	arrangement	NN
cord-005941-e4fvj54l	194	3	remains	remain	VBZ
cord-005941-e4fvj54l	194	4	stable	stable	JJ
cord-005941-e4fvj54l	194	5	through	through	IN
cord-005941-e4fvj54l	194	6	ventilatory	ventilatory	JJ
cord-005941-e4fvj54l	194	7	compression	compression	NN
cord-005941-e4fvj54l	194	8	and	and	CC
cord-005941-e4fvj54l	194	9	extension	extension	NN
cord-005941-e4fvj54l	194	10	of	of	IN
cord-005941-e4fvj54l	194	11	the	the	DT
cord-005941-e4fvj54l	194	12	alveolus	alveolus	NN
cord-005941-e4fvj54l	194	13	and	and	CC
cord-005941-e4fvj54l	194	14	reduces	reduce	VBZ
cord-005941-e4fvj54l	194	15	the	the	DT
cord-005941-e4fvj54l	194	16	strong	strong	JJ
cord-005941-e4fvj54l	194	17	alveolar	alveolar	NN
cord-005941-e4fvj54l	194	18	cohesive	cohesive	JJ
cord-005941-e4fvj54l	194	19	forces	force	NNS
cord-005941-e4fvj54l	194	20	close	close	JJ
cord-005941-e4fvj54l	194	21	to	to	IN
cord-005941-e4fvj54l	194	22	zero	zero	CD
cord-005941-e4fvj54l	194	23	.	.	.
cord-005941-e4fvj54l	195	1	Thus	thus	RB
cord-005941-e4fvj54l	195	2	,	,	,
cord-005941-e4fvj54l	195	3	alveolar	alveolar	NN
cord-005941-e4fvj54l	195	4	surfactant	surfactant	NN
cord-005941-e4fvj54l	195	5	material	material	NN
cord-005941-e4fvj54l	195	6	successfully	successfully	RB
cord-005941-e4fvj54l	195	7	prevents	prevent	VBZ
cord-005941-e4fvj54l	195	8	alveolar	alveolar	JJ
cord-005941-e4fvj54l	195	9	collapse	collapse	NN
cord-005941-e4fvj54l	195	10	and	and	CC
cord-005941-e4fvj54l	195	11	atelectasis	atelectasis	NN
cord-005941-e4fvj54l	195	12	as	as	IN
cord-005941-e4fvj54l	195	13	observed	observe	VBN
cord-005941-e4fvj54l	195	14	in	in	IN
cord-005941-e4fvj54l	195	15	surfactant	surfactant	NN
cord-005941-e4fvj54l	195	16	-	-	HYPH
cord-005941-e4fvj54l	195	17	deficient	deficient	JJ
cord-005941-e4fvj54l	195	18	lungs	lung	NNS
cord-005941-e4fvj54l	195	19	,	,	,
cord-005941-e4fvj54l	195	20	e.g.	e.g.	RB
cord-005941-e4fvj54l	195	21	,	,	,
cord-005941-e4fvj54l	195	22	in	in	IN
cord-005941-e4fvj54l	195	23	IRDS	IRDS	NNP
cord-005941-e4fvj54l	195	24	.	.	.
cord-005941-e4fvj54l	196	1	Surfactant	surfactant	NN
cord-005941-e4fvj54l	196	2	material	material	NN
cord-005941-e4fvj54l	196	3	may	may	MD
cord-005941-e4fvj54l	196	4	contribute	contribute	VB
cord-005941-e4fvj54l	196	5	to	to	IN
cord-005941-e4fvj54l	196	6	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	196	7	defense	defense	NN
cord-005941-e4fvj54l	196	8	mechanisms	mechanism	NNS
cord-005941-e4fvj54l	196	9	and	and	CC
cord-005941-e4fvj54l	196	10	local	local	JJ
cord-005941-e4fvj54l	196	11	immunomodulation	immunomodulation	NN
cord-005941-e4fvj54l	196	12	in	in	IN
cord-005941-e4fvj54l	196	13	four	four	CD
cord-005941-e4fvj54l	196	14	different	different	JJ
cord-005941-e4fvj54l	196	15	ways	way	NNS
cord-005941-e4fvj54l	196	16	:	:	:
cord-005941-e4fvj54l	196	17	-Support	-support	DT
cord-005941-e4fvj54l	196	18	of	of	IN
cord-005941-e4fvj54l	196	19	nonspecific	nonspecific	JJ
cord-005941-e4fvj54l	196	20	defense	defense	NN
cord-005941-e4fvj54l	196	21	mechanisms	mechanism	NNS
cord-005941-e4fvj54l	196	22	-Direct	-Direct	:
cord-005941-e4fvj54l	196	23	bactericidal	bactericidal	JJ
cord-005941-e4fvj54l	196	24	properties	property	NNS
cord-005941-e4fvj54l	196	25	of	of	IN
cord-005941-e4fvj54l	196	26	surfactant	surfactant	NN
cord-005941-e4fvj54l	196	27	components	component	NNS
cord-005941-e4fvj54l	196	28	-Immunomodulatory	-immunomodulatory	NN
cord-005941-e4fvj54l	196	29	action	action	NN
cord-005941-e4fvj54l	196	30	on	on	IN
cord-005941-e4fvj54l	196	31	lymphocytes	lymphocyte	NNS
cord-005941-e4fvj54l	196	32	-Augmentation	-augmentation	NN
cord-005941-e4fvj54l	196	33	of	of	IN
cord-005941-e4fvj54l	196	34	macrophage	macrophage	NN
cord-005941-e4fvj54l	196	35	activities	activity	NNS
cord-005941-e4fvj54l	196	36	in	in	IN
cord-005941-e4fvj54l	196	37	the	the	DT
cord-005941-e4fvj54l	196	38	alveolar	alveolar	JJ
cord-005941-e4fvj54l	196	39	milieu	milieu	NN
cord-005941-e4fvj54l	197	1	Surfactant	surfactant	NN
cord-005941-e4fvj54l	197	2	is	be	VBZ
cord-005941-e4fvj54l	197	3	part	part	NN
cord-005941-e4fvj54l	197	4	of	of	IN
cord-005941-e4fvj54l	197	5	the	the	DT
cord-005941-e4fvj54l	197	6	alveolar	alveolar	JJ
cord-005941-e4fvj54l	197	7	and	and	CC
cord-005941-e4fvj54l	197	8	bronchial	bronchial	JJ
cord-005941-e4fvj54l	197	9	epithelial	epithelial	JJ
cord-005941-e4fvj54l	197	10	lining	lining	NN
cord-005941-e4fvj54l	197	11	fluid	fluid	NN
cord-005941-e4fvj54l	197	12	which	which	WDT
cord-005941-e4fvj54l	197	13	is	be	VBZ
cord-005941-e4fvj54l	197	14	thought	think	VBN
cord-005941-e4fvj54l	197	15	to	to	TO
cord-005941-e4fvj54l	197	16	act	act	VB
cord-005941-e4fvj54l	197	17	as	as	IN
cord-005941-e4fvj54l	197	18	a	a	DT
cord-005941-e4fvj54l	197	19	nonspecific	nonspecific	JJ
cord-005941-e4fvj54l	197	20	barrier	barrier	NN
cord-005941-e4fvj54l	197	21	against	against	IN
cord-005941-e4fvj54l	197	22	adhesion	adhesion	NN
cord-005941-e4fvj54l	197	23	and	and	CC
cord-005941-e4fvj54l	197	24	invasion	invasion	NN
cord-005941-e4fvj54l	197	25	of	of	IN
cord-005941-e4fvj54l	197	26	microorganisms	microorganism	NNS
cord-005941-e4fvj54l	197	27	.	.	.
cord-005941-e4fvj54l	198	1	Also	also	RB
cord-005941-e4fvj54l	198	2	,	,	,
cord-005941-e4fvj54l	198	3	surfactant	surfactant	NN
cord-005941-e4fvj54l	198	4	has	have	VBZ
cord-005941-e4fvj54l	198	5	antioxidant	antioxidant	JJ
cord-005941-e4fvj54l	198	6	activities	activity	NNS
cord-005941-e4fvj54l	198	7	[	[	-LRB-
cord-005941-e4fvj54l	198	8	115	115	CD
cord-005941-e4fvj54l	198	9	]	]	-RRB-
cord-005941-e4fvj54l	198	10	which	which	WDT
cord-005941-e4fvj54l	198	11	may	may	MD
cord-005941-e4fvj54l	198	12	contribute	contribute	VB
cord-005941-e4fvj54l	198	13	to	to	IN
cord-005941-e4fvj54l	198	14	the	the	DT
cord-005941-e4fvj54l	198	15	protection	protection	NN
cord-005941-e4fvj54l	198	16	of	of	IN
cord-005941-e4fvj54l	198	17	the	the	DT
cord-005941-e4fvj54l	198	18	alveolar	alveolar	JJ
cord-005941-e4fvj54l	198	19	epithelium	epithelium	NN
cord-005941-e4fvj54l	198	20	by	by	IN
cord-005941-e4fvj54l	198	21	scavenging	scavenge	VBG
cord-005941-e4fvj54l	198	22	toxic	toxic	JJ
cord-005941-e4fvj54l	198	23	(	(	-LRB-
cord-005941-e4fvj54l	198	24	reduced	reduced	JJ
cord-005941-e4fvj54l	198	25	)	)	-RRB-
cord-005941-e4fvj54l	198	26	oxygen	oxygen	NN
cord-005941-e4fvj54l	198	27	species	specie	NNS
cord-005941-e4fvj54l	198	28	.	.	.
cord-005941-e4fvj54l	199	1	Several	several	JJ
cord-005941-e4fvj54l	199	2	reports	report	NNS
cord-005941-e4fvj54l	199	3	have	have	VBP
cord-005941-e4fvj54l	199	4	addressed	address	VBN
cord-005941-e4fvj54l	199	5	the	the	DT
cord-005941-e4fvj54l	199	6	possible	possible	JJ
cord-005941-e4fvj54l	199	7	antibacterial	antibacterial	JJ
cord-005941-e4fvj54l	199	8	properties	property	NNS
cord-005941-e4fvj54l	199	9	of	of	IN
cord-005941-e4fvj54l	199	10	surfactant	surfactant	NN
cord-005941-e4fvj54l	199	11	material	material	NN
cord-005941-e4fvj54l	199	12	.	.	.
cord-005941-e4fvj54l	200	1	Studies	study	NNS
cord-005941-e4fvj54l	200	2	of	of	IN
cord-005941-e4fvj54l	200	3	rat	rat	NN
cord-005941-e4fvj54l	200	4	alveolar	alveolar	NN
cord-005941-e4fvj54l	200	5	lining	lining	NN
cord-005941-e4fvj54l	200	6	material	material	NN
cord-005941-e4fvj54l	200	7	identified	identify	VBD
cord-005941-e4fvj54l	200	8	long	long	JJ
cord-005941-e4fvj54l	200	9	-	-	HYPH
cord-005941-e4fvj54l	200	10	chain	chain	NN
cord-005941-e4fvj54l	200	11	free	free	JJ
cord-005941-e4fvj54l	200	12	fatty	fatty	JJ
cord-005941-e4fvj54l	200	13	acids	acid	NNS
cord-005941-e4fvj54l	200	14	as	as	IN
cord-005941-e4fvj54l	200	15	bactericidal	bactericidal	JJ
cord-005941-e4fvj54l	200	16	surfactant	surfactant	NN
cord-005941-e4fvj54l	200	17	components	component	NNS
cord-005941-e4fvj54l	200	18	and	and	CC
cord-005941-e4fvj54l	200	19	demonstrated	demonstrate	VBD
cord-005941-e4fvj54l	200	20	their	-PRON-	PRP$
cord-005941-e4fvj54l	200	21	antibiotic	antibiotic	JJ
cord-005941-e4fvj54l	200	22	action	action	NN
cord-005941-e4fvj54l	200	23	against	against	IN
cord-005941-e4fvj54l	200	24	pneumococci	pneumococci	NNP
cord-005941-e4fvj54l	200	25	in	in	IN
cord-005941-e4fvj54l	200	26	vitro	vitro	FW
cord-005941-e4fvj54l	200	27	[	[	-LRB-
cord-005941-e4fvj54l	200	28	24	24	CD
cord-005941-e4fvj54l	200	29	]	]	-RRB-
cord-005941-e4fvj54l	200	30	.	.	.
cord-005941-e4fvj54l	201	1	However	however	RB
cord-005941-e4fvj54l	201	2	,	,	,
cord-005941-e4fvj54l	201	3	studies	study	NNS
cord-005941-e4fvj54l	201	4	of	of	IN
cord-005941-e4fvj54l	201	5	human	human	JJ
cord-005941-e4fvj54l	201	6	alveolar	alveolar	NN
cord-005941-e4fvj54l	201	7	lining	lining	NN
cord-005941-e4fvj54l	201	8	material	material	NN
cord-005941-e4fvj54l	201	9	obtained	obtain	VBN
cord-005941-e4fvj54l	201	10	by	by	IN
cord-005941-e4fvj54l	201	11	BAL	BAL	NNP
cord-005941-e4fvj54l	201	12	could	could	MD
cord-005941-e4fvj54l	201	13	not	not	RB
cord-005941-e4fvj54l	201	14	demonstrate	demonstrate	VB
cord-005941-e4fvj54l	201	15	antibacterial	antibacterial	JJ
cord-005941-e4fvj54l	201	16	effects	effect	NNS
cord-005941-e4fvj54l	201	17	against	against	IN
cord-005941-e4fvj54l	201	18	pneumococci	pneumococcus	NNS
cord-005941-e4fvj54l	201	19	or	or	CC
cord-005941-e4fvj54l	201	20	Haemophilus	haemophilus	JJ
cord-005941-e4fvj54l	201	21	influenzae	influenzae	NN
cord-005941-e4fvj54l	201	22	[	[	-LRB-
cord-005941-e4fvj54l	201	23	86	86	CD
cord-005941-e4fvj54l	201	24	]	]	-RRB-
cord-005941-e4fvj54l	201	25	.	.	.
cord-005941-e4fvj54l	202	1	The	the	DT
cord-005941-e4fvj54l	202	2	in	in	IN
cord-005941-e4fvj54l	202	3	vivo	vivo	NN
cord-005941-e4fvj54l	202	4	significance	significance	NN
cord-005941-e4fvj54l	202	5	of	of	IN
cord-005941-e4fvj54l	202	6	these	these	DT
cord-005941-e4fvj54l	202	7	findings	finding	NNS
cord-005941-e4fvj54l	202	8	is	be	VBZ
cord-005941-e4fvj54l	202	9	still	still	RB
cord-005941-e4fvj54l	202	10	uncertain	uncertain	JJ
cord-005941-e4fvj54l	202	11	,	,	,
cord-005941-e4fvj54l	202	12	and	and	CC
cord-005941-e4fvj54l	202	13	the	the	DT
cord-005941-e4fvj54l	202	14	antibiotic	antibiotic	JJ
cord-005941-e4fvj54l	202	15	effect	effect	NN
cord-005941-e4fvj54l	202	16	of	of	IN
cord-005941-e4fvj54l	202	17	surfacrant	surfacrant	NNP
cord-005941-e4fvj54l	202	18	remains	remain	VBZ
cord-005941-e4fvj54l	202	19	controversial	controversial	JJ
cord-005941-e4fvj54l	202	20	.	.	.
cord-005941-e4fvj54l	203	1	Lung	lung	NN
cord-005941-e4fvj54l	203	2	surfactant	surfactant	NN
cord-005941-e4fvj54l	203	3	has	have	VBZ
cord-005941-e4fvj54l	203	4	been	be	VBN
cord-005941-e4fvj54l	203	5	shown	show	VBN
cord-005941-e4fvj54l	203	6	to	to	TO
cord-005941-e4fvj54l	203	7	influence	influence	VB
cord-005941-e4fvj54l	203	8	the	the	DT
cord-005941-e4fvj54l	203	9	activities	activity	NNS
cord-005941-e4fvj54l	203	10	of	of	IN
cord-005941-e4fvj54l	203	11	lymphocytes	lymphocyte	NNS
cord-005941-e4fvj54l	203	12	and	and	CC
cord-005941-e4fvj54l	203	13	macrophages	macrophage	NNS
cord-005941-e4fvj54l	203	14	.	.	.
cord-005941-e4fvj54l	204	1	These	these	DT
cord-005941-e4fvj54l	204	2	influences	influence	NNS
cord-005941-e4fvj54l	204	3	are	be	VBP
cord-005941-e4fvj54l	204	4	probably	probably	RB
cord-005941-e4fvj54l	204	5	of	of	IN
cord-005941-e4fvj54l	204	6	significant	significant	JJ
cord-005941-e4fvj54l	204	7	in	in	IN
cord-005941-e4fvj54l	204	8	vivo	vivo	NN
cord-005941-e4fvj54l	204	9	importance	importance	NN
cord-005941-e4fvj54l	204	10	for	for	IN
cord-005941-e4fvj54l	204	11	the	the	DT
cord-005941-e4fvj54l	204	12	maintenance	maintenance	NN
cord-005941-e4fvj54l	204	13	of	of	IN
cord-005941-e4fvj54l	204	14	a	a	DT
cord-005941-e4fvj54l	204	15	balance	balance	NN
cord-005941-e4fvj54l	204	16	between	between	IN
cord-005941-e4fvj54l	204	17	excessive	excessive	JJ
cord-005941-e4fvj54l	204	18	immune	immune	JJ
cord-005941-e4fvj54l	204	19	responses	response	NNS
cord-005941-e4fvj54l	204	20	and	and	CC
cord-005941-e4fvj54l	204	21	favorable	favorable	JJ
cord-005941-e4fvj54l	204	22	cellular	cellular	JJ
cord-005941-e4fvj54l	204	23	defense	defense	NN
cord-005941-e4fvj54l	204	24	mechanisms	mechanism	NNS
cord-005941-e4fvj54l	204	25	.	.	.
cord-005941-e4fvj54l	205	1	Surfactant	surfactant	NN
cord-005941-e4fvj54l	205	2	suppresses	suppress	VBZ
cord-005941-e4fvj54l	205	3	the	the	DT
cord-005941-e4fvj54l	205	4	activation	activation	NN
cord-005941-e4fvj54l	205	5	and	and	CC
cord-005941-e4fvj54l	205	6	the	the	DT
cord-005941-e4fvj54l	205	7	proliferative	proliferative	JJ
cord-005941-e4fvj54l	205	8	response	response	NN
cord-005941-e4fvj54l	205	9	of	of	IN
cord-005941-e4fvj54l	205	10	lymphocytes	lymphocyte	NNS
cord-005941-e4fvj54l	205	11	to	to	IN
cord-005941-e4fvj54l	205	12	various	various	JJ
cord-005941-e4fvj54l	205	13	stimuli	stimulus	NNS
cord-005941-e4fvj54l	205	14	in	in	IN
cord-005941-e4fvj54l	205	15	a	a	DT
cord-005941-e4fvj54l	205	16	dose	dose	NN
cord-005941-e4fvj54l	205	17	-	-	HYPH
cord-005941-e4fvj54l	205	18	dependent	dependent	JJ
cord-005941-e4fvj54l	205	19	manner	manner	NN
cord-005941-e4fvj54l	205	20	[	[	-LRB-
cord-005941-e4fvj54l	205	21	17	17	CD
cord-005941-e4fvj54l	205	22	,	,	,
cord-005941-e4fvj54l	205	23	164	164	CD
cord-005941-e4fvj54l	205	24	,	,	,
cord-005941-e4fvj54l	205	25	192	192	CD
cord-005941-e4fvj54l	205	26	]	]	-RRB-
cord-005941-e4fvj54l	205	27	.	.	.
cord-005941-e4fvj54l	206	1	This	this	DT
cord-005941-e4fvj54l	206	2	suppressor	suppressor	NN
cord-005941-e4fvj54l	206	3	activity	activity	NN
cord-005941-e4fvj54l	206	4	is	be	VBZ
cord-005941-e4fvj54l	206	5	contained	contain	VBN
cord-005941-e4fvj54l	206	6	in	in	IN
cord-005941-e4fvj54l	206	7	the	the	DT
cord-005941-e4fvj54l	206	8	lipid	lipid	NN
cord-005941-e4fvj54l	206	9	fraction	fraction	NN
cord-005941-e4fvj54l	206	10	of	of	IN
cord-005941-e4fvj54l	206	11	surfactant	surfactant	NN
cord-005941-e4fvj54l	206	12	[	[	-LRB-
cord-005941-e4fvj54l	206	13	17	17	CD
cord-005941-e4fvj54l	206	14	]	]	-RRB-
cord-005941-e4fvj54l	206	15	.	.	.
cord-005941-e4fvj54l	207	1	The	the	DT
cord-005941-e4fvj54l	207	2	major	major	JJ
cord-005941-e4fvj54l	207	3	surfactant	surfactant	NN
cord-005941-e4fvj54l	207	4	phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	207	5	phosphatidylcholine	phosphatidylcholine	NN
cord-005941-e4fvj54l	207	6	,	,	,
cord-005941-e4fvj54l	207	7	phosphatidylglycerol	phosphatidylglycerol	NNP
cord-005941-e4fvj54l	207	8	,	,	,
cord-005941-e4fvj54l	207	9	and	and	CC
cord-005941-e4fvj54l	207	10	phosphatidylinositol	phosphatidylinositol	JJ
cord-005941-e4fvj54l	207	11	were	be	VBD
cord-005941-e4fvj54l	207	12	shown	show	VBN
cord-005941-e4fvj54l	207	13	to	to	TO
cord-005941-e4fvj54l	207	14	be	be	VB
cord-005941-e4fvj54l	207	15	responsible	responsible	JJ
cord-005941-e4fvj54l	207	16	for	for	IN
cord-005941-e4fvj54l	207	17	this	this	DT
cord-005941-e4fvj54l	207	18	immunoregulatory	immunoregulatory	JJ
cord-005941-e4fvj54l	207	19	effect	effect	NN
cord-005941-e4fvj54l	207	20	.	.	.
cord-005941-e4fvj54l	208	1	The	the	DT
cord-005941-e4fvj54l	208	2	mechanism	mechanism	NN
cord-005941-e4fvj54l	208	3	of	of	IN
cord-005941-e4fvj54l	208	4	this	this	DT
cord-005941-e4fvj54l	208	5	effect	effect	NN
cord-005941-e4fvj54l	208	6	has	have	VBZ
cord-005941-e4fvj54l	208	7	not	not	RB
cord-005941-e4fvj54l	208	8	yet	yet	RB
cord-005941-e4fvj54l	208	9	been	be	VBN
cord-005941-e4fvj54l	208	10	clarified	clarify	VBN
cord-005941-e4fvj54l	208	11	but	but	CC
cord-005941-e4fvj54l	208	12	may	may	MD
cord-005941-e4fvj54l	208	13	be	be	VB
cord-005941-e4fvj54l	208	14	related	relate	VBN
cord-005941-e4fvj54l	208	15	to	to	IN
cord-005941-e4fvj54l	208	16	changes	change	NNS
cord-005941-e4fvj54l	208	17	in	in	IN
cord-005941-e4fvj54l	208	18	cell	cell	NN
cord-005941-e4fvj54l	208	19	membrane	membrane	NN
cord-005941-e4fvj54l	208	20	dynamics	dynamic	NNS
cord-005941-e4fvj54l	208	21	[	[	-LRB-
cord-005941-e4fvj54l	208	22	193	193	CD
cord-005941-e4fvj54l	208	23	]	]	-RRB-
cord-005941-e4fvj54l	208	24	.	.	.
cord-005941-e4fvj54l	209	1	Surfactant	surfactant	NN
cord-005941-e4fvj54l	209	2	exerts	exert	VBZ
cord-005941-e4fvj54l	209	3	its	-PRON-	PRP$
cord-005941-e4fvj54l	209	4	effects	effect	NNS
cord-005941-e4fvj54l	209	5	only	only	RB
cord-005941-e4fvj54l	209	6	on	on	IN
cord-005941-e4fvj54l	209	7	the	the	DT
cord-005941-e4fvj54l	209	8	resting	rest	VBG
cord-005941-e4fvj54l	209	9	lymphocyte	lymphocyte	NN
cord-005941-e4fvj54l	209	10	or	or	CC
cord-005941-e4fvj54l	209	11	on	on	IN
cord-005941-e4fvj54l	209	12	the	the	DT
cord-005941-e4fvj54l	209	13	early	early	JJ
cord-005941-e4fvj54l	209	14	stage	stage	NN
cord-005941-e4fvj54l	209	15	of	of	IN
cord-005941-e4fvj54l	209	16	lymphocyte	lymphocyte	NN
cord-005941-e4fvj54l	209	17	activation	activation	NN
cord-005941-e4fvj54l	209	18	.	.	.
cord-005941-e4fvj54l	210	1	Activated	activate	VBN
cord-005941-e4fvj54l	210	2	lymphocytes	lymphocyte	NNS
cord-005941-e4fvj54l	210	3	are	be	VBP
cord-005941-e4fvj54l	210	4	not	not	RB
cord-005941-e4fvj54l	210	5	affected	affect	VBN
cord-005941-e4fvj54l	210	6	.	.	.
cord-005941-e4fvj54l	211	1	The	the	DT
cord-005941-e4fvj54l	211	2	suppression	suppression	NN
cord-005941-e4fvj54l	211	3	seems	seem	VBZ
cord-005941-e4fvj54l	211	4	to	to	TO
cord-005941-e4fvj54l	211	5	be	be	VB
cord-005941-e4fvj54l	211	6	largely	largely	RB
cord-005941-e4fvj54l	211	7	irreversible	irreversible	JJ
cord-005941-e4fvj54l	211	8	,	,	,
cord-005941-e4fvj54l	211	9	even	even	RB
cord-005941-e4fvj54l	211	10	after	after	IN
cord-005941-e4fvj54l	211	11	the	the	DT
cord-005941-e4fvj54l	211	12	removal	removal	NN
cord-005941-e4fvj54l	211	13	of	of	IN
cord-005941-e4fvj54l	211	14	surfactant	surfactant	NN
cord-005941-e4fvj54l	211	15	material	material	NN
cord-005941-e4fvj54l	211	16	from	from	IN
cord-005941-e4fvj54l	211	17	the	the	DT
cord-005941-e4fvj54l	211	18	medium	medium	NN
cord-005941-e4fvj54l	211	19	.	.	.
cord-005941-e4fvj54l	212	1	The	the	DT
cord-005941-e4fvj54l	212	2	inhibitory	inhibitory	JJ
cord-005941-e4fvj54l	212	3	effects	effect	NNS
cord-005941-e4fvj54l	212	4	of	of	IN
cord-005941-e4fvj54l	212	5	surfactant	surfactant	NN
cord-005941-e4fvj54l	212	6	have	have	VBP
cord-005941-e4fvj54l	212	7	been	be	VBN
cord-005941-e4fvj54l	212	8	shown	show	VBN
cord-005941-e4fvj54l	212	9	for	for	IN
cord-005941-e4fvj54l	212	10	a	a	DT
cord-005941-e4fvj54l	212	11	variety	variety	NN
cord-005941-e4fvj54l	212	12	of	of	IN
cord-005941-e4fvj54l	212	13	lymphocyte	lymphocyte	NN
cord-005941-e4fvj54l	212	14	activities	activity	NNS
cord-005941-e4fvj54l	212	15	such	such	JJ
cord-005941-e4fvj54l	212	16	as	as	IN
cord-005941-e4fvj54l	212	17	proliferation	proliferation	NN
cord-005941-e4fvj54l	212	18	,	,	,
cord-005941-e4fvj54l	212	19	differentiation	differentiation	NN
cord-005941-e4fvj54l	212	20	,	,	,
cord-005941-e4fvj54l	212	21	immunoglobulin	immunoglobulin	NN
cord-005941-e4fvj54l	212	22	production	production	NN
cord-005941-e4fvj54l	212	23	,	,	,
cord-005941-e4fvj54l	212	24	and	and	CC
cord-005941-e4fvj54l	212	25	natural	natural	JJ
cord-005941-e4fvj54l	212	26	killer	killer	NN
cord-005941-e4fvj54l	212	27	cell	cell	NN
cord-005941-e4fvj54l	212	28	activity	activity	NN
cord-005941-e4fvj54l	212	29	[	[	-LRB-
cord-005941-e4fvj54l	212	30	10	10	CD
cord-005941-e4fvj54l	212	31	,	,	,
cord-005941-e4fvj54l	212	32	17	17	CD
cord-005941-e4fvj54l	212	33	,	,	,
cord-005941-e4fvj54l	212	34	164	164	CD
cord-005941-e4fvj54l	212	35	,	,	,
cord-005941-e4fvj54l	212	36	192	192	CD
cord-005941-e4fvj54l	212	37	,	,	,
cord-005941-e4fvj54l	212	38	193	193	CD
cord-005941-e4fvj54l	212	39	]	]	-RRB-
cord-005941-e4fvj54l	212	40	.	.	.
cord-005941-e4fvj54l	213	1	Nearly	nearly	RB
cord-005941-e4fvj54l	213	2	all	all	DT
cord-005941-e4fvj54l	213	3	studies	study	NNS
cord-005941-e4fvj54l	213	4	on	on	IN
cord-005941-e4fvj54l	213	5	the	the	DT
cord-005941-e4fvj54l	213	6	influence	influence	NN
cord-005941-e4fvj54l	213	7	of	of	IN
cord-005941-e4fvj54l	213	8	surfactant	surfactant	NN
cord-005941-e4fvj54l	213	9	on	on	IN
cord-005941-e4fvj54l	213	10	alveolar	alveolar	JJ
cord-005941-e4fvj54l	213	11	macrophage	macrophage	NN
cord-005941-e4fvj54l	213	12	activity	activity	NN
cord-005941-e4fvj54l	213	13	report	report	VBP
cord-005941-e4fvj54l	213	14	an	an	DT
cord-005941-e4fvj54l	213	15	enhancement	enhancement	NN
cord-005941-e4fvj54l	213	16	of	of	IN
cord-005941-e4fvj54l	213	17	macrophage	macrophage	NN
cord-005941-e4fvj54l	213	18	functions	function	NNS
cord-005941-e4fvj54l	213	19	.	.	.
cord-005941-e4fvj54l	214	1	In	in	IN
cord-005941-e4fvj54l	214	2	detail	detail	NN
cord-005941-e4fvj54l	214	3	,	,	,
cord-005941-e4fvj54l	214	4	it	-PRON-	PRP
cord-005941-e4fvj54l	214	5	has	have	VBZ
cord-005941-e4fvj54l	214	6	been	be	VBN
cord-005941-e4fvj54l	214	7	shown	show	VBN
cord-005941-e4fvj54l	214	8	that	that	IN
cord-005941-e4fvj54l	214	9	surfactant	surfactant	NN
cord-005941-e4fvj54l	214	10	material	material	NN
cord-005941-e4fvj54l	214	11	supports	support	VBZ
cord-005941-e4fvj54l	214	12	phagocytosis	phagocytosis	NN
cord-005941-e4fvj54l	214	13	[	[	-LRB-
cord-005941-e4fvj54l	214	14	131	131	CD
cord-005941-e4fvj54l	214	15	,	,	,
cord-005941-e4fvj54l	214	16	177	177	CD
cord-005941-e4fvj54l	214	17	]	]	-RRB-
cord-005941-e4fvj54l	214	18	and	and	CC
cord-005941-e4fvj54l	214	19	intracellular	intracellular	JJ
cord-005941-e4fvj54l	214	20	killing	kill	VBG
cord-005941-e4fvj54l	214	21	[	[	-LRB-
cord-005941-e4fvj54l	214	22	88	88	CD
cord-005941-e4fvj54l	214	23	,	,	,
cord-005941-e4fvj54l	214	24	131	131	CD
cord-005941-e4fvj54l	214	25	]	]	-RRB-
cord-005941-e4fvj54l	214	26	of	of	IN
cord-005941-e4fvj54l	214	27	Staphylococcus	Staphylococcus	NNP
cord-005941-e4fvj54l	214	28	aureus	aureus	NN
cord-005941-e4fvj54l	214	29	and	and	CC
cord-005941-e4fvj54l	214	30	the	the	DT
cord-005941-e4fvj54l	214	31	phagocytosis	phagocytosis	NN
cord-005941-e4fvj54l	214	32	of	of	IN
cord-005941-e4fvj54l	214	33	herpes	herpes	NNP
cord-005941-e4fvj54l	214	34	simplex	simplex	NNP
cord-005941-e4fvj54l	214	35	virus	virus	NN
cord-005941-e4fvj54l	214	36	type	type	NN
cord-005941-e4fvj54l	214	37	1	1	CD
cord-005941-e4fvj54l	214	38	[	[	-LRB-
cord-005941-e4fvj54l	214	39	178	178	CD
cord-005941-e4fvj54l	214	40	]	]	-RRB-
cord-005941-e4fvj54l	214	41	.	.	.
cord-005941-e4fvj54l	215	1	It	-PRON-	PRP
cord-005941-e4fvj54l	215	2	may	may	MD
cord-005941-e4fvj54l	215	3	also	also	RB
cord-005941-e4fvj54l	215	4	enhance	enhance	VB
cord-005941-e4fvj54l	215	5	the	the	DT
cord-005941-e4fvj54l	215	6	migration	migration	NN
cord-005941-e4fvj54l	215	7	of	of	IN
cord-005941-e4fvj54l	215	8	alveolar	alveolar	JJ
cord-005941-e4fvj54l	215	9	macrophages	macrophage	NNS
cord-005941-e4fvj54l	215	10	[	[	-LRB-
cord-005941-e4fvj54l	215	11	159	159	CD
cord-005941-e4fvj54l	215	12	]	]	-RRB-
cord-005941-e4fvj54l	215	13	and	and	CC
cord-005941-e4fvj54l	215	14	their	-PRON-	PRP$
cord-005941-e4fvj54l	215	15	cytotoxicity	cytotoxicity	NN
cord-005941-e4fvj54l	215	16	against	against	IN
cord-005941-e4fvj54l	215	17	tumor	tumor	NN
cord-005941-e4fvj54l	215	18	cells	cell	NNS
cord-005941-e4fvj54l	215	19	[	[	-LRB-
cord-005941-e4fvj54l	215	20	13	13	CD
cord-005941-e4fvj54l	215	21	]	]	-RRB-
cord-005941-e4fvj54l	215	22	.	.	.
cord-005941-e4fvj54l	216	1	It	-PRON-	PRP
cord-005941-e4fvj54l	216	2	has	have	VBZ
cord-005941-e4fvj54l	216	3	to	to	TO
cord-005941-e4fvj54l	216	4	be	be	VB
cord-005941-e4fvj54l	216	5	stressed	stress	VBN
cord-005941-e4fvj54l	216	6	that	that	IN
cord-005941-e4fvj54l	216	7	these	these	DT
cord-005941-e4fvj54l	216	8	studies	study	NNS
cord-005941-e4fvj54l	216	9	report	report	VBP
cord-005941-e4fvj54l	216	10	the	the	DT
cord-005941-e4fvj54l	216	11	results	result	NNS
cord-005941-e4fvj54l	216	12	of	of	IN
cord-005941-e4fvj54l	216	13	in	in	FW
cord-005941-e4fvj54l	216	14	vitro	vitro	FW
cord-005941-e4fvj54l	216	15	investigations	investigation	NNS
cord-005941-e4fvj54l	216	16	mostly	mostly	RB
cord-005941-e4fvj54l	216	17	with	with	IN
cord-005941-e4fvj54l	216	18	animal	animal	NN
cord-005941-e4fvj54l	216	19	material	material	NN
cord-005941-e4fvj54l	216	20	.	.	.
cord-005941-e4fvj54l	217	1	Thus	thus	RB
cord-005941-e4fvj54l	217	2	,	,	,
cord-005941-e4fvj54l	217	3	the	the	DT
cord-005941-e4fvj54l	217	4	significance	significance	NN
cord-005941-e4fvj54l	217	5	of	of	IN
cord-005941-e4fvj54l	217	6	these	these	DT
cord-005941-e4fvj54l	217	7	findings	finding	NNS
cord-005941-e4fvj54l	217	8	for	for	IN
cord-005941-e4fvj54l	217	9	normal	normal	JJ
cord-005941-e4fvj54l	217	10	human	human	JJ
cord-005941-e4fvj54l	217	11	lung	lung	NN
cord-005941-e4fvj54l	217	12	defense	defense	NN
cord-005941-e4fvj54l	217	13	mechanisms	mechanism	NNS
cord-005941-e4fvj54l	217	14	is	be	VBZ
cord-005941-e4fvj54l	217	15	not	not	RB
cord-005941-e4fvj54l	217	16	yet	yet	RB
cord-005941-e4fvj54l	217	17	definitely	definitely	RB
cord-005941-e4fvj54l	217	18	established	establish	VBN
cord-005941-e4fvj54l	217	19	.	.	.
cord-005941-e4fvj54l	218	1	In	in	IN
cord-005941-e4fvj54l	218	2	general	general	JJ
cord-005941-e4fvj54l	218	3	,	,	,
cord-005941-e4fvj54l	218	4	alveolar	alveolar	JJ
cord-005941-e4fvj54l	218	5	macrophages	macrophage	NNS
cord-005941-e4fvj54l	218	6	are	be	VBP
cord-005941-e4fvj54l	218	7	thought	think	VBN
cord-005941-e4fvj54l	218	8	to	to	TO
cord-005941-e4fvj54l	218	9	be	be	VB
cord-005941-e4fvj54l	218	10	less	less	RBR
cord-005941-e4fvj54l	218	11	active	active	JJ
cord-005941-e4fvj54l	218	12	than	than	IN
cord-005941-e4fvj54l	218	13	blood	blood	NN
cord-005941-e4fvj54l	218	14	monocytes	monocyte	NNS
cord-005941-e4fvj54l	218	15	or	or	CC
cord-005941-e4fvj54l	218	16	macrophages	macrophage	NNS
cord-005941-e4fvj54l	218	17	residing	reside	VBG
cord-005941-e4fvj54l	218	18	in	in	IN
cord-005941-e4fvj54l	218	19	other	other	JJ
cord-005941-e4fvj54l	218	20	tissues	tissue	NNS
cord-005941-e4fvj54l	218	21	[	[	-LRB-
cord-005941-e4fvj54l	218	22	75	75	CD
cord-005941-e4fvj54l	218	23	,	,	,
cord-005941-e4fvj54l	218	24	150	150	CD
cord-005941-e4fvj54l	218	25	]	]	-RRB-
cord-005941-e4fvj54l	218	26	.	.	.
cord-005941-e4fvj54l	219	1	Recent	recent	JJ
cord-005941-e4fvj54l	219	2	studies	study	NNS
cord-005941-e4fvj54l	219	3	[	[	-LRB-
cord-005941-e4fvj54l	219	4	171	171	CD
cord-005941-e4fvj54l	219	5	,	,	,
cord-005941-e4fvj54l	219	6	177	177	CD
cord-005941-e4fvj54l	219	7	,	,	,
cord-005941-e4fvj54l	219	8	178	178	CD
cord-005941-e4fvj54l	219	9	]	]	-RRB-
cord-005941-e4fvj54l	219	10	have	have	VBP
cord-005941-e4fvj54l	219	11	shown	show	VBN
cord-005941-e4fvj54l	219	12	that	that	IN
cord-005941-e4fvj54l	219	13	SP	SP	NNP
cord-005941-e4fvj54l	219	14	-	-	HYPH
cord-005941-e4fvj54l	219	15	A	A	NNP
cord-005941-e4fvj54l	219	16	is	be	VBZ
cord-005941-e4fvj54l	219	17	probably	probably	RB
cord-005941-e4fvj54l	219	18	responsible	responsible	JJ
cord-005941-e4fvj54l	219	19	for	for	IN
cord-005941-e4fvj54l	219	20	the	the	DT
cord-005941-e4fvj54l	219	21	enhancement	enhancement	NN
cord-005941-e4fvj54l	219	22	of	of	IN
cord-005941-e4fvj54l	219	23	alveolar	alveolar	JJ
cord-005941-e4fvj54l	219	24	macrophage	macrophage	NN
cord-005941-e4fvj54l	219	25	functions	function	NNS
cord-005941-e4fvj54l	219	26	as	as	IN
cord-005941-e4fvj54l	219	27	isolated	isolate	VBN
cord-005941-e4fvj54l	219	28	SP	SP	NNP
cord-005941-e4fvj54l	219	29	-	-	HYPH
cord-005941-e4fvj54l	219	30	A	A	NNP
cord-005941-e4fvj54l	219	31	had	have	VBD
cord-005941-e4fvj54l	219	32	the	the	DT
cord-005941-e4fvj54l	219	33	same	same	JJ
cord-005941-e4fvj54l	219	34	stimulant	stimulant	NN
cord-005941-e4fvj54l	219	35	effect	effect	NN
cord-005941-e4fvj54l	219	36	on	on	IN
cord-005941-e4fvj54l	219	37	macrophages	macrophage	NNS
cord-005941-e4fvj54l	219	38	as	as	IN
cord-005941-e4fvj54l	219	39	whole	whole	JJ
cord-005941-e4fvj54l	219	40	surfactant	surfactant	NN
cord-005941-e4fvj54l	219	41	,	,	,
cord-005941-e4fvj54l	219	42	while	while	IN
cord-005941-e4fvj54l	219	43	surfactant	surfactant	NN
cord-005941-e4fvj54l	219	44	lipids	lipid	NNS
cord-005941-e4fvj54l	219	45	had	have	VBD
cord-005941-e4fvj54l	219	46	no	no	DT
cord-005941-e4fvj54l	219	47	effect	effect	NN
cord-005941-e4fvj54l	219	48	[	[	-LRB-
cord-005941-e4fvj54l	219	49	177	177	CD
cord-005941-e4fvj54l	219	50	]	]	-RRB-
cord-005941-e4fvj54l	219	51	.	.	.
cord-005941-e4fvj54l	220	1	Probably	probably	RB
cord-005941-e4fvj54l	220	2	,	,	,
cord-005941-e4fvj54l	220	3	this	this	DT
cord-005941-e4fvj54l	220	4	macrophage	macrophage	NN
cord-005941-e4fvj54l	220	5	stimulation	stimulation	NN
cord-005941-e4fvj54l	220	6	is	be	VBZ
cord-005941-e4fvj54l	220	7	mediated	mediate	VBN
cord-005941-e4fvj54l	220	8	by	by	IN
cord-005941-e4fvj54l	220	9	a	a	DT
cord-005941-e4fvj54l	220	10	macrophage	macrophage	NN
cord-005941-e4fvj54l	220	11	receptor	receptor	NN
cord-005941-e4fvj54l	220	12	which	which	WDT
cord-005941-e4fvj54l	220	13	binds	bind	VBZ
cord-005941-e4fvj54l	220	14	SP	SP	NNP
cord-005941-e4fvj54l	220	15	-	-	HYPH
cord-005941-e4fvj54l	220	16	A.	a.	NN
cord-005941-e4fvj54l	221	1	The	the	DT
cord-005941-e4fvj54l	221	2	specific	specific	JJ
cord-005941-e4fvj54l	221	3	binding	binding	NN
cord-005941-e4fvj54l	221	4	and	and	CC
cord-005941-e4fvj54l	221	5	uptake	uptake	NN
cord-005941-e4fvj54l	221	6	of	of	IN
cord-005941-e4fvj54l	221	7	SP	SP	NNP
cord-005941-e4fvj54l	221	8	-	-	HYPH
cord-005941-e4fvj54l	221	9	A	a	NN
cord-005941-e4fvj54l	221	10	by	by	IN
cord-005941-e4fvj54l	221	11	macrophages	macrophage	NNS
cord-005941-e4fvj54l	221	12	has	have	VBZ
cord-005941-e4fvj54l	221	13	been	be	VBN
cord-005941-e4fvj54l	221	14	demonstrated	demonstrate	VBN
cord-005941-e4fvj54l	221	15	by	by	IN
cord-005941-e4fvj54l	221	16	electron	electron	NN
cord-005941-e4fvj54l	221	17	microscopy	microscopy	NNP
cord-005941-e4fvj54l	221	18	[	[	-LRB-
cord-005941-e4fvj54l	221	19	110	110	CD
cord-005941-e4fvj54l	221	20	]	]	-RRB-
cord-005941-e4fvj54l	221	21	.	.	.
cord-005941-e4fvj54l	222	1	A	a	DT
cord-005941-e4fvj54l	222	2	recent	recent	JJ
cord-005941-e4fvj54l	222	3	report	report	NN
cord-005941-e4fvj54l	222	4	[	[	-LRB-
cord-005941-e4fvj54l	222	5	109	109	CD
cord-005941-e4fvj54l	222	6	]	]	-RRB-
cord-005941-e4fvj54l	222	7	suggests	suggest	VBZ
cord-005941-e4fvj54l	222	8	that	that	IN
cord-005941-e4fvj54l	222	9	the	the	DT
cord-005941-e4fvj54l	222	10	SP	SP	NNP
cord-005941-e4fvj54l	222	11	-	-	HYPH
cord-005941-e4fvj54l	222	12	A	A	NNP
cord-005941-e4fvj54l	222	13	receptor	receptor	NN
cord-005941-e4fvj54l	222	14	may	may	MD
cord-005941-e4fvj54l	222	15	be	be	VB
cord-005941-e4fvj54l	222	16	identical	identical	JJ
cord-005941-e4fvj54l	222	17	with	with	IN
cord-005941-e4fvj54l	222	18	the	the	DT
cord-005941-e4fvj54l	222	19	leukocyte	leukocyte	NN
cord-005941-e4fvj54l	222	20	Clq	Clq	NNP
cord-005941-e4fvj54l	222	21	receptor	receptor	NN
cord-005941-e4fvj54l	222	22	,	,	,
cord-005941-e4fvj54l	222	23	which	which	WDT
cord-005941-e4fvj54l	222	24	is	be	VBZ
cord-005941-e4fvj54l	222	25	a	a	DT
cord-005941-e4fvj54l	222	26	tempting	tempting	JJ
cord-005941-e4fvj54l	222	27	hypothesis	hypothesis	NN
cord-005941-e4fvj54l	222	28	since	since	IN
cord-005941-e4fvj54l	222	29	SP	SP	NNP
cord-005941-e4fvj54l	222	30	-	-	HYPH
cord-005941-e4fvj54l	222	31	A	A	NNP
cord-005941-e4fvj54l	222	32	has	have	VBZ
cord-005941-e4fvj54l	222	33	structural	structural	JJ
cord-005941-e4fvj54l	222	34	homologies	homology	NNS
cord-005941-e4fvj54l	222	35	with	with	IN
cord-005941-e4fvj54l	222	36	the	the	DT
cord-005941-e4fvj54l	222	37	complement	complement	NN
cord-005941-e4fvj54l	222	38	protein	protein	NN
cord-005941-e4fvj54l	222	39	Clq	Clq	NNP
cord-005941-e4fvj54l	222	40	.	.	.
cord-005941-e4fvj54l	223	1	Surfactant	surfactant	NN
cord-005941-e4fvj54l	223	2	material	material	NN
cord-005941-e4fvj54l	223	3	,	,	,
cord-005941-e4fvj54l	223	4	as	as	IN
cord-005941-e4fvj54l	223	5	part	part	NN
cord-005941-e4fvj54l	223	6	of	of	IN
cord-005941-e4fvj54l	223	7	the	the	DT
cord-005941-e4fvj54l	223	8	alveolar	alveolar	JJ
cord-005941-e4fvj54l	223	9	epithelial	epithelial	JJ
cord-005941-e4fvj54l	223	10	lining	lining	NN
cord-005941-e4fvj54l	223	11	fluid	fluid	NN
cord-005941-e4fvj54l	223	12	,	,	,
cord-005941-e4fvj54l	223	13	is	be	VBZ
cord-005941-e4fvj54l	223	14	thought	think	VBN
cord-005941-e4fvj54l	223	15	to	to	TO
cord-005941-e4fvj54l	223	16	represent	represent	VB
cord-005941-e4fvj54l	223	17	a	a	DT
cord-005941-e4fvj54l	223	18	first	first	JJ
cord-005941-e4fvj54l	223	19	defense	defense	NN
cord-005941-e4fvj54l	223	20	line	line	NN
cord-005941-e4fvj54l	223	21	against	against	IN
cord-005941-e4fvj54l	223	22	inhaled	inhale	VBN
cord-005941-e4fvj54l	223	23	particles	particle	NNS
cord-005941-e4fvj54l	223	24	and	and	CC
cord-005941-e4fvj54l	223	25	gases	gas	NNS
cord-005941-e4fvj54l	223	26	reaching	reach	VBG
cord-005941-e4fvj54l	223	27	the	the	DT
cord-005941-e4fvj54l	223	28	alveolar	alveolar	JJ
cord-005941-e4fvj54l	223	29	space	space	NN
cord-005941-e4fvj54l	223	30	.	.	.
cord-005941-e4fvj54l	224	1	Apart	apart	RB
cord-005941-e4fvj54l	224	2	from	from	IN
cord-005941-e4fvj54l	224	3	building	build	VBG
cord-005941-e4fvj54l	224	4	a	a	DT
cord-005941-e4fvj54l	224	5	"	"	``
cord-005941-e4fvj54l	224	6	mechanical	mechanical	JJ
cord-005941-e4fvj54l	224	7	"	"	''
cord-005941-e4fvj54l	224	8	barrier	barrier	NN
cord-005941-e4fvj54l	224	9	,	,	,
cord-005941-e4fvj54l	224	10	it	-PRON-	PRP
cord-005941-e4fvj54l	224	11	probably	probably	RB
cord-005941-e4fvj54l	224	12	plays	play	VBZ
cord-005941-e4fvj54l	224	13	an	an	DT
cord-005941-e4fvj54l	224	14	active	active	JJ
cord-005941-e4fvj54l	224	15	role	role	NN
cord-005941-e4fvj54l	224	16	in	in	IN
cord-005941-e4fvj54l	224	17	the	the	DT
cord-005941-e4fvj54l	224	18	elimination	elimination	NN
cord-005941-e4fvj54l	224	19	of	of	IN
cord-005941-e4fvj54l	224	20	foreign	foreign	JJ
cord-005941-e4fvj54l	224	21	particles	particle	NNS
cord-005941-e4fvj54l	224	22	,	,	,
cord-005941-e4fvj54l	224	23	e.g.	e.g.	RB
cord-005941-e4fvj54l	224	24	,	,	,
cord-005941-e4fvj54l	224	25	by	by	IN
cord-005941-e4fvj54l	224	26	enhancing	enhance	VBG
cord-005941-e4fvj54l	224	27	macrophage	macrophage	NN
cord-005941-e4fvj54l	224	28	activities	activity	NNS
cord-005941-e4fvj54l	224	29	and	and	CC
cord-005941-e4fvj54l	224	30	by	by	IN
cord-005941-e4fvj54l	224	31	exerting	exert	VBG
cord-005941-e4fvj54l	224	32	antioxidant	antioxidant	JJ
cord-005941-e4fvj54l	224	33	effects	effect	NNS
cord-005941-e4fvj54l	224	34	[	[	-LRB-
cord-005941-e4fvj54l	224	35	115	115	CD
cord-005941-e4fvj54l	224	36	]	]	-RRB-
cord-005941-e4fvj54l	224	37	against	against	IN
cord-005941-e4fvj54l	224	38	a	a	DT
cord-005941-e4fvj54l	224	39	variety	variety	NN
cord-005941-e4fvj54l	224	40	of	of	IN
cord-005941-e4fvj54l	224	41	oxidant	oxidant	JJ
cord-005941-e4fvj54l	224	42	gases	gas	NNS
cord-005941-e4fvj54l	224	43	.	.	.
cord-005941-e4fvj54l	225	1	On	on	IN
cord-005941-e4fvj54l	225	2	the	the	DT
cord-005941-e4fvj54l	225	3	other	other	JJ
cord-005941-e4fvj54l	225	4	hand	hand	NN
cord-005941-e4fvj54l	225	5	,	,	,
cord-005941-e4fvj54l	225	6	the	the	DT
cord-005941-e4fvj54l	225	7	surfactant	surfactant	NN
cord-005941-e4fvj54l	225	8	system	system	NN
cord-005941-e4fvj54l	225	9	itself	-PRON-	PRP
cord-005941-e4fvj54l	225	10	may	may	MD
cord-005941-e4fvj54l	225	11	be	be	VB
cord-005941-e4fvj54l	225	12	damaged	damage	VBN
cord-005941-e4fvj54l	225	13	by	by	IN
cord-005941-e4fvj54l	225	14	inhaled	inhale	VBN
cord-005941-e4fvj54l	225	15	particles	particle	NNS
cord-005941-e4fvj54l	225	16	and	and	CC
cord-005941-e4fvj54l	225	17	gases	gas	NNS
cord-005941-e4fvj54l	225	18	.	.	.
cord-005941-e4fvj54l	226	1	A	a	DT
cord-005941-e4fvj54l	226	2	number	number	NN
cord-005941-e4fvj54l	226	3	of	of	IN
cord-005941-e4fvj54l	226	4	studies	study	NNS
cord-005941-e4fvj54l	226	5	have	have	VBP
cord-005941-e4fvj54l	226	6	been	be	VBN
cord-005941-e4fvj54l	226	7	published	publish	VBN
cord-005941-e4fvj54l	226	8	addressing	address	VBG
cord-005941-e4fvj54l	226	9	the	the	DT
cord-005941-e4fvj54l	226	10	impact	impact	NN
cord-005941-e4fvj54l	226	11	of	of	IN
cord-005941-e4fvj54l	226	12	air	air	NN
cord-005941-e4fvj54l	226	13	pollutants	pollutant	NNS
cord-005941-e4fvj54l	226	14	and	and	CC
cord-005941-e4fvj54l	226	15	other	other	JJ
cord-005941-e4fvj54l	226	16	toxicants	toxicant	NNS
cord-005941-e4fvj54l	226	17	on	on	IN
cord-005941-e4fvj54l	226	18	the	the	DT
cord-005941-e4fvj54l	226	19	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	226	20	surfactant	surfactant	NN
cord-005941-e4fvj54l	226	21	system	system	NN
cord-005941-e4fvj54l	226	22	.	.	.
cord-005941-e4fvj54l	227	1	Varying	vary	VBG
cord-005941-e4fvj54l	227	2	study	study	NN
cord-005941-e4fvj54l	227	3	designs	design	NNS
cord-005941-e4fvj54l	227	4	such	such	JJ
cord-005941-e4fvj54l	227	5	as	as	IN
cord-005941-e4fvj54l	227	6	the	the	DT
cord-005941-e4fvj54l	227	7	use	use	NN
cord-005941-e4fvj54l	227	8	of	of	IN
cord-005941-e4fvj54l	227	9	different	different	JJ
cord-005941-e4fvj54l	227	10	animal	animal	NN
cord-005941-e4fvj54l	227	11	or	or	CC
cord-005941-e4fvj54l	227	12	in	in	IN
cord-005941-e4fvj54l	227	13	vitro	vitro	FW
cord-005941-e4fvj54l	227	14	models	model	NNS
cord-005941-e4fvj54l	227	15	and	and	CC
cord-005941-e4fvj54l	227	16	different	different	JJ
cord-005941-e4fvj54l	227	17	doses	dose	NNS
cord-005941-e4fvj54l	227	18	and	and	CC
cord-005941-e4fvj54l	227	19	exposure	exposure	NN
cord-005941-e4fvj54l	227	20	times	time	NNS
cord-005941-e4fvj54l	227	21	have	have	VBP
cord-005941-e4fvj54l	227	22	led	lead	VBN
cord-005941-e4fvj54l	227	23	to	to	IN
cord-005941-e4fvj54l	227	24	divergent	divergent	JJ
cord-005941-e4fvj54l	227	25	and	and	CC
cord-005941-e4fvj54l	227	26	sometimes	sometimes	RB
cord-005941-e4fvj54l	227	27	conflicting	conflict	VBG
cord-005941-e4fvj54l	227	28	results	result	NNS
cord-005941-e4fvj54l	227	29	.	.	.
cord-005941-e4fvj54l	228	1	Furthermore	furthermore	RB
cord-005941-e4fvj54l	228	2	,	,	,
cord-005941-e4fvj54l	228	3	some	some	DT
cord-005941-e4fvj54l	228	4	of	of	IN
cord-005941-e4fvj54l	228	5	the	the	DT
cord-005941-e4fvj54l	228	6	studies	study	NNS
cord-005941-e4fvj54l	228	7	focussing	focusse	VBG
cord-005941-e4fvj54l	228	8	only	only	RB
cord-005941-e4fvj54l	228	9	on	on	IN
cord-005941-e4fvj54l	228	10	phospholipid	phospholipid	NN
cord-005941-e4fvj54l	228	11	alterations	alteration	NNS
cord-005941-e4fvj54l	228	12	leave	leave	VBP
cord-005941-e4fvj54l	228	13	some	some	DT
cord-005941-e4fvj54l	228	14	doubt	doubt	NN
cord-005941-e4fvj54l	228	15	as	as	IN
cord-005941-e4fvj54l	228	16	to	to	IN
cord-005941-e4fvj54l	228	17	whether	whether	IN
cord-005941-e4fvj54l	228	18	these	these	DT
cord-005941-e4fvj54l	228	19	changes	change	NNS
cord-005941-e4fvj54l	228	20	are	be	VBP
cord-005941-e4fvj54l	228	21	truly	truly	RB
cord-005941-e4fvj54l	228	22	related	relate	VBN
cord-005941-e4fvj54l	228	23	to	to	IN
cord-005941-e4fvj54l	228	24	surfactant	surfactant	NN
cord-005941-e4fvj54l	228	25	abnormalities	abnormality	NNS
cord-005941-e4fvj54l	228	26	or	or	CC
cord-005941-e4fvj54l	228	27	rather	rather	RB
cord-005941-e4fvj54l	228	28	reflect	reflect	VBP
cord-005941-e4fvj54l	228	29	other	other	JJ
cord-005941-e4fvj54l	228	30	mechanisms	mechanism	NNS
cord-005941-e4fvj54l	228	31	like	like	IN
cord-005941-e4fvj54l	228	32	unspecific	unspecific	JJ
cord-005941-e4fvj54l	228	33	cell	cell	NN
cord-005941-e4fvj54l	228	34	membrane	membrane	NN
cord-005941-e4fvj54l	228	35	damage	damage	NN
cord-005941-e4fvj54l	228	36	.	.	.
cord-005941-e4fvj54l	229	1	It	-PRON-	PRP
cord-005941-e4fvj54l	229	2	certainly	certainly	RB
cord-005941-e4fvj54l	229	3	has	have	VBZ
cord-005941-e4fvj54l	229	4	to	to	TO
cord-005941-e4fvj54l	229	5	be	be	VB
cord-005941-e4fvj54l	229	6	kept	keep	VBN
cord-005941-e4fvj54l	229	7	in	in	IN
cord-005941-e4fvj54l	229	8	mind	mind	NN
cord-005941-e4fvj54l	229	9	that	that	IN
cord-005941-e4fvj54l	229	10	the	the	DT
cord-005941-e4fvj54l	229	11	surfactant	surfactant	NN
cord-005941-e4fvj54l	229	12	system	system	NN
cord-005941-e4fvj54l	229	13	is	be	VBZ
cord-005941-e4fvj54l	229	14	only	only	RB
cord-005941-e4fvj54l	229	15	one	one	CD
cord-005941-e4fvj54l	229	16	of	of	IN
cord-005941-e4fvj54l	229	17	the	the	DT
cord-005941-e4fvj54l	229	18	potential	potential	JJ
cord-005941-e4fvj54l	229	19	targets	target	NNS
cord-005941-e4fvj54l	229	20	of	of	IN
cord-005941-e4fvj54l	229	21	pollutants	pollutant	NNS
cord-005941-e4fvj54l	229	22	and	and	CC
cord-005941-e4fvj54l	229	23	toxicants	toxicant	NNS
cord-005941-e4fvj54l	229	24	reaching	reach	VBG
cord-005941-e4fvj54l	229	25	the	the	DT
cord-005941-e4fvj54l	229	26	lung	lung	NN
cord-005941-e4fvj54l	229	27	periphery	periphery	NN
cord-005941-e4fvj54l	229	28	,	,	,
cord-005941-e4fvj54l	229	29	and	and	CC
cord-005941-e4fvj54l	230	1	hazardous	hazardous	JJ
cord-005941-e4fvj54l	230	2	effects	effect	NNS
cord-005941-e4fvj54l	230	3	on	on	IN
cord-005941-e4fvj54l	230	4	the	the	DT
cord-005941-e4fvj54l	230	5	surfactant	surfactant	NN
cord-005941-e4fvj54l	230	6	system	system	NN
cord-005941-e4fvj54l	230	7	may	may	MD
cord-005941-e4fvj54l	230	8	be	be	VB
cord-005941-e4fvj54l	230	9	of	of	IN
cord-005941-e4fvj54l	230	10	a	a	DT
cord-005941-e4fvj54l	230	11	direct	direct	JJ
cord-005941-e4fvj54l	230	12	or	or	CC
cord-005941-e4fvj54l	230	13	indirect	indirect	JJ
cord-005941-e4fvj54l	230	14	or	or	CC
cord-005941-e4fvj54l	230	15	as	as	RB
cord-005941-e4fvj54l	230	16	yet	yet	RB
cord-005941-e4fvj54l	230	17	unknown	unknown	JJ
cord-005941-e4fvj54l	230	18	nature	nature	NN
cord-005941-e4fvj54l	230	19	.	.	.
cord-005941-e4fvj54l	231	1	This	this	DT
cord-005941-e4fvj54l	231	2	review	review	NN
cord-005941-e4fvj54l	231	3	will	will	MD
cord-005941-e4fvj54l	231	4	only	only	RB
cord-005941-e4fvj54l	231	5	give	give	VB
cord-005941-e4fvj54l	231	6	a	a	DT
cord-005941-e4fvj54l	231	7	short	short	JJ
cord-005941-e4fvj54l	231	8	overview	overview	NN
cord-005941-e4fvj54l	231	9	of	of	IN
cord-005941-e4fvj54l	231	10	the	the	DT
cord-005941-e4fvj54l	231	11	known	know	VBN
cord-005941-e4fvj54l	231	12	or	or	CC
cord-005941-e4fvj54l	231	13	proposed	propose	VBN
cord-005941-e4fvj54l	231	14	effects	effect	NNS
cord-005941-e4fvj54l	231	15	of	of	IN
cord-005941-e4fvj54l	231	16	some	some	DT
cord-005941-e4fvj54l	231	17	pollutants	pollutant	NNS
cord-005941-e4fvj54l	231	18	and	and	CC
cord-005941-e4fvj54l	231	19	toxicants	toxicant	NNS
cord-005941-e4fvj54l	231	20	on	on	IN
cord-005941-e4fvj54l	231	21	the	the	DT
cord-005941-e4fvj54l	231	22	surfactant	surfactant	NN
cord-005941-e4fvj54l	231	23	system	system	NN
cord-005941-e4fvj54l	231	24	.	.	.
cord-005941-e4fvj54l	232	1	For	for	IN
cord-005941-e4fvj54l	232	2	further	further	JJ
cord-005941-e4fvj54l	232	3	information	information	NN
cord-005941-e4fvj54l	232	4	,	,	,
cord-005941-e4fvj54l	232	5	the	the	DT
cord-005941-e4fvj54l	232	6	reader	reader	NN
cord-005941-e4fvj54l	232	7	is	be	VBZ
cord-005941-e4fvj54l	232	8	referred	refer	VBN
cord-005941-e4fvj54l	232	9	to	to	IN
cord-005941-e4fvj54l	232	10	a	a	DT
cord-005941-e4fvj54l	232	11	number	number	NN
cord-005941-e4fvj54l	232	12	of	of	IN
cord-005941-e4fvj54l	232	13	reviews	review	NNS
cord-005941-e4fvj54l	232	14	and	and	CC
cord-005941-e4fvj54l	232	15	articles	article	NNS
cord-005941-e4fvj54l	232	16	focussing	focusse	VBG
cord-005941-e4fvj54l	232	17	on	on	IN
cord-005941-e4fvj54l	232	18	this	this	DT
cord-005941-e4fvj54l	232	19	subject	subject	NN
cord-005941-e4fvj54l	232	20	[	[	-LRB-
cord-005941-e4fvj54l	232	21	40	40	CD
cord-005941-e4fvj54l	232	22	,	,	,
cord-005941-e4fvj54l	232	23	55	55	CD
cord-005941-e4fvj54l	232	24	,	,	,
cord-005941-e4fvj54l	232	25	119	119	CD
cord-005941-e4fvj54l	232	26	,	,	,
cord-005941-e4fvj54l	232	27	120	120	CD
cord-005941-e4fvj54l	232	28	,	,	,
cord-005941-e4fvj54l	232	29	 	 	_SP
cord-005941-e4fvj54l	233	1	Ozone	ozone	NN
cord-005941-e4fvj54l	233	2	is	be	VBZ
cord-005941-e4fvj54l	233	3	a	a	DT
cord-005941-e4fvj54l	233	4	major	major	JJ
cord-005941-e4fvj54l	233	5	component	component	NN
cord-005941-e4fvj54l	233	6	of	of	IN
cord-005941-e4fvj54l	233	7	photochemical	photochemical	JJ
cord-005941-e4fvj54l	233	8	smog	smog	NN
cord-005941-e4fvj54l	233	9	.	.	.
cord-005941-e4fvj54l	234	1	It	-PRON-	PRP
cord-005941-e4fvj54l	234	2	acts	act	VBZ
cord-005941-e4fvj54l	234	3	as	as	IN
cord-005941-e4fvj54l	234	4	a	a	DT
cord-005941-e4fvj54l	234	5	highly	highly	RB
cord-005941-e4fvj54l	234	6	aggressive	aggressive	JJ
cord-005941-e4fvj54l	234	7	oxidant	oxidant	NN
cord-005941-e4fvj54l	234	8	and	and	CC
cord-005941-e4fvj54l	234	9	leads	lead	VBZ
cord-005941-e4fvj54l	234	10	to	to	IN
cord-005941-e4fvj54l	234	11	the	the	DT
cord-005941-e4fvj54l	234	12	transudation	transudation	NN
cord-005941-e4fvj54l	234	13	of	of	IN
cord-005941-e4fvj54l	234	14	blood	blood	NN
cord-005941-e4fvj54l	234	15	proteins	protein	NNS
cord-005941-e4fvj54l	234	16	and	and	CC
cord-005941-e4fvj54l	234	17	to	to	TO
cord-005941-e4fvj54l	234	18	edema	edema	VB
cord-005941-e4fvj54l	234	19	in	in	IN
cord-005941-e4fvj54l	234	20	the	the	DT
cord-005941-e4fvj54l	234	21	alveolar	alveolar	JJ
cord-005941-e4fvj54l	234	22	space	space	NN
cord-005941-e4fvj54l	234	23	even	even	RB
cord-005941-e4fvj54l	234	24	at	at	IN
cord-005941-e4fvj54l	234	25	comparatively	comparatively	RB
cord-005941-e4fvj54l	234	26	low	low	JJ
cord-005941-e4fvj54l	234	27	concentrations	concentration	NNS
cord-005941-e4fvj54l	234	28	.	.	.
cord-005941-e4fvj54l	235	1	Furthermore	furthermore	RB
cord-005941-e4fvj54l	235	2	,	,	,
cord-005941-e4fvj54l	235	3	chronic	chronic	JJ
cord-005941-e4fvj54l	235	4	low	low	JJ
cord-005941-e4fvj54l	235	5	-	-	HYPH
cord-005941-e4fvj54l	235	6	dose	dose	NN
cord-005941-e4fvj54l	235	7	ozone	ozone	NN
cord-005941-e4fvj54l	235	8	exposure	exposure	NN
cord-005941-e4fvj54l	235	9	is	be	VBZ
cord-005941-e4fvj54l	235	10	known	know	VBN
cord-005941-e4fvj54l	235	11	to	to	TO
cord-005941-e4fvj54l	235	12	increase	increase	VB
cord-005941-e4fvj54l	235	13	the	the	DT
cord-005941-e4fvj54l	235	14	susceptibility	susceptibility	NN
cord-005941-e4fvj54l	235	15	to	to	IN
cord-005941-e4fvj54l	235	16	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	235	17	infections	infection	NNS
cord-005941-e4fvj54l	235	18	.	.	.
cord-005941-e4fvj54l	236	1	It	-PRON-	PRP
cord-005941-e4fvj54l	236	2	is	be	VBZ
cord-005941-e4fvj54l	236	3	believed	believe	VBN
cord-005941-e4fvj54l	236	4	that	that	IN
cord-005941-e4fvj54l	236	5	the	the	DT
cord-005941-e4fvj54l	236	6	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	236	7	toxicity	toxicity	NN
cord-005941-e4fvj54l	236	8	of	of	IN
cord-005941-e4fvj54l	236	9	ozone	ozone	NN
cord-005941-e4fvj54l	236	10	is	be	VBZ
cord-005941-e4fvj54l	236	11	at	at	IN
cord-005941-e4fvj54l	236	12	least	least	JJS
cord-005941-e4fvj54l	236	13	in	in	IN
cord-005941-e4fvj54l	236	14	part	part	NN
cord-005941-e4fvj54l	236	15	due	due	IN
cord-005941-e4fvj54l	236	16	to	to	IN
cord-005941-e4fvj54l	236	17	impairment	impairment	NN
cord-005941-e4fvj54l	236	18	of	of	IN
cord-005941-e4fvj54l	236	19	the	the	DT
cord-005941-e4fvj54l	236	20	surfactant	surfactant	NN
cord-005941-e4fvj54l	236	21	system	system	NN
cord-005941-e4fvj54l	236	22	[	[	-LRB-
cord-005941-e4fvj54l	236	23	55	55	CD
cord-005941-e4fvj54l	236	24	]	]	-RRB-
cord-005941-e4fvj54l	236	25	.	.	.
cord-005941-e4fvj54l	237	1	Several	several	JJ
cord-005941-e4fvj54l	237	2	reports	report	NNS
cord-005941-e4fvj54l	237	3	support	support	VBP
cord-005941-e4fvj54l	237	4	this	this	DT
cord-005941-e4fvj54l	237	5	hypothesis	hypothesis	NN
cord-005941-e4fvj54l	237	6	.	.	.
cord-005941-e4fvj54l	238	1	In	in	IN
cord-005941-e4fvj54l	238	2	rats	rat	NNS
cord-005941-e4fvj54l	238	3	exposed	expose	VBN
cord-005941-e4fvj54l	238	4	to	to	IN
cord-005941-e4fvj54l	238	5	0.3	0.3	CD
cord-005941-e4fvj54l	238	6	ppm	ppm	NN
cord-005941-e4fvj54l	238	7	of	of	IN
cord-005941-e4fvj54l	238	8	ozone	ozone	NN
cord-005941-e4fvj54l	238	9	for	for	IN
cord-005941-e4fvj54l	238	10	16	16	CD
cord-005941-e4fvj54l	238	11	days	day	NNS
cord-005941-e4fvj54l	238	12	,	,	,
cord-005941-e4fvj54l	238	13	giant	giant	JJ
cord-005941-e4fvj54l	238	14	lamellar	lamellar	JJ
cord-005941-e4fvj54l	238	15	bodies	body	NNS
cord-005941-e4fvj54l	238	16	were	be	VBD
cord-005941-e4fvj54l	238	17	observed	observe	VBN
cord-005941-e4fvj54l	238	18	in	in	IN
cord-005941-e4fvj54l	238	19	the	the	DT
cord-005941-e4fvj54l	238	20	alveolar	alveolar	JJ
cord-005941-e4fvj54l	238	21	type	type	NN
cord-005941-e4fvj54l	238	22	II	ii	CD
cord-005941-e4fvj54l	238	23	cells	cell	NNS
cord-005941-e4fvj54l	238	24	after	after	IN
cord-005941-e4fvj54l	238	25	day	day	NN
cord-005941-e4fvj54l	238	26	11	11	CD
cord-005941-e4fvj54l	238	27	.	.	.
cord-005941-e4fvj54l	239	1	This	this	DT
cord-005941-e4fvj54l	239	2	could	could	MD
cord-005941-e4fvj54l	239	3	suggest	suggest	VB
cord-005941-e4fvj54l	239	4	that	that	IN
cord-005941-e4fvj54l	239	5	ozone	ozone	NN
cord-005941-e4fvj54l	239	6	may	may	MD
cord-005941-e4fvj54l	239	7	impair	impair	VB
cord-005941-e4fvj54l	239	8	surfactant	surfactant	NN
cord-005941-e4fvj54l	239	9	secretion	secretion	NN
cord-005941-e4fvj54l	239	10	[	[	-LRB-
cord-005941-e4fvj54l	239	11	163	163	CD
cord-005941-e4fvj54l	239	12	]	]	-RRB-
cord-005941-e4fvj54l	239	13	.	.	.
cord-005941-e4fvj54l	240	1	Short	short	JJ
cord-005941-e4fvj54l	240	2	-	-	HYPH
cord-005941-e4fvj54l	240	3	term	term	NN
cord-005941-e4fvj54l	240	4	exposure	exposure	NN
cord-005941-e4fvj54l	240	5	(	(	-LRB-
cord-005941-e4fvj54l	240	6	2.5	2.5	CD
cord-005941-e4fvj54l	240	7	h	h	NN
cord-005941-e4fvj54l	240	8	)	)	-RRB-
cord-005941-e4fvj54l	240	9	of	of	IN
cord-005941-e4fvj54l	240	10	isolated	isolate	VBN
cord-005941-e4fvj54l	240	11	rat	rat	NN
cord-005941-e4fvj54l	240	12	alveolar	alveolar	NN
cord-005941-e4fvj54l	240	13	type	type	NN
cord-005941-e4fvj54l	240	14	II	ii	CD
cord-005941-e4fvj54l	240	15	cells	cell	NNS
cord-005941-e4fvj54l	240	16	to	to	IN
cord-005941-e4fvj54l	240	17	variable	variable	JJ
cord-005941-e4fvj54l	240	18	amounts	amount	NNS
cord-005941-e4fvj54l	240	19	of	of	IN
cord-005941-e4fvj54l	240	20	ozone	ozone	NN
cord-005941-e4fvj54l	240	21	resulted	result	VBD
cord-005941-e4fvj54l	240	22	in	in	IN
cord-005941-e4fvj54l	240	23	impaired	impaired	JJ
cord-005941-e4fvj54l	240	24	intracellular	intracellular	JJ
cord-005941-e4fvj54l	240	25	synthesis	synthesis	NN
cord-005941-e4fvj54l	240	26	of	of	IN
cord-005941-e4fvj54l	240	27	phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	240	28	[	[	-LRB-
cord-005941-e4fvj54l	240	29	57	57	CD
cord-005941-e4fvj54l	240	30	]	]	-RRB-
cord-005941-e4fvj54l	240	31	.	.	.
cord-005941-e4fvj54l	241	1	Exposure	exposure	NN
cord-005941-e4fvj54l	241	2	of	of	IN
cord-005941-e4fvj54l	241	3	bonnet	bonnet	NN
cord-005941-e4fvj54l	241	4	monkeys	monkey	NNS
cord-005941-e4fvj54l	241	5	to	to	TO
cord-005941-e4fvj54l	241	6	variable	variable	JJ
cord-005941-e4fvj54l	241	7	low	low	JJ
cord-005941-e4fvj54l	241	8	-	-	HYPH
cord-005941-e4fvj54l	241	9	dose	dose	NN
cord-005941-e4fvj54l	241	10	concentrations	concentration	NNS
cord-005941-e4fvj54l	241	11	of	of	IN
cord-005941-e4fvj54l	241	12	ozone	ozone	NN
cord-005941-e4fvj54l	241	13	for	for	IN
cord-005941-e4fvj54l	241	14	21	21	CD
cord-005941-e4fvj54l	241	15	-	-	SYM
cord-005941-e4fvj54l	241	16	90	90	CD
cord-005941-e4fvj54l	241	17	days	day	NNS
cord-005941-e4fvj54l	241	18	led	lead	VBD
cord-005941-e4fvj54l	241	19	to	to	IN
cord-005941-e4fvj54l	241	20	changes	change	NNS
cord-005941-e4fvj54l	241	21	of	of	IN
cord-005941-e4fvj54l	241	22	fatty	fatty	JJ
cord-005941-e4fvj54l	241	23	acid	acid	NN
cord-005941-e4fvj54l	241	24	compositions	composition	NNS
cord-005941-e4fvj54l	241	25	and	and	CC
cord-005941-e4fvj54l	241	26	a	a	DT
cord-005941-e4fvj54l	241	27	marked	marked	JJ
cord-005941-e4fvj54l	241	28	increase	increase	NN
cord-005941-e4fvj54l	241	29	in	in	IN
cord-005941-e4fvj54l	241	30	phosphatidylcholine	phosphatidylcholine	NN
cord-005941-e4fvj54l	241	31	levels	level	NNS
cord-005941-e4fvj54l	241	32	in	in	IN
cord-005941-e4fvj54l	241	33	lung	lung	NN
cord-005941-e4fvj54l	241	34	lavage	lavage	NN
cord-005941-e4fvj54l	241	35	fluids	fluid	NNS
cord-005941-e4fvj54l	241	36	[	[	-LRB-
cord-005941-e4fvj54l	241	37	149	149	CD
cord-005941-e4fvj54l	241	38	]	]	-RRB-
cord-005941-e4fvj54l	241	39	.	.	.
cord-005941-e4fvj54l	242	1	Short	short	JJ
cord-005941-e4fvj54l	242	2	-	-	HYPH
cord-005941-e4fvj54l	242	3	term	term	NN
cord-005941-e4fvj54l	242	4	(	(	-LRB-
cord-005941-e4fvj54l	242	5	1	1	CD
cord-005941-e4fvj54l	242	6	-	-	SYM
cord-005941-e4fvj54l	242	7	8	8	CD
cord-005941-e4fvj54l	242	8	h	h	NN
cord-005941-e4fvj54l	242	9	)	)	-RRB-
cord-005941-e4fvj54l	242	10	,	,	,
cord-005941-e4fvj54l	242	11	high	high	JJ
cord-005941-e4fvj54l	242	12	dose	dose	NN
cord-005941-e4fvj54l	242	13	(	(	-LRB-
cord-005941-e4fvj54l	242	14	3	3	CD
cord-005941-e4fvj54l	242	15	ppm	ppm	NN
cord-005941-e4fvj54l	242	16	)	)	-RRB-
cord-005941-e4fvj54l	243	1	ozone	ozone	NN
cord-005941-e4fvj54l	243	2	exposure	exposure	NN
cord-005941-e4fvj54l	243	3	of	of	IN
cord-005941-e4fvj54l	243	4	rats	rat	NNS
cord-005941-e4fvj54l	243	5	resulted	result	VBD
cord-005941-e4fvj54l	243	6	in	in	IN
cord-005941-e4fvj54l	243	7	ultrastructural	ultrastructural	JJ
cord-005941-e4fvj54l	243	8	alterations	alteration	NNS
cord-005941-e4fvj54l	243	9	of	of	IN
cord-005941-e4fvj54l	243	10	intracellular	intracellular	JJ
cord-005941-e4fvj54l	243	11	lamellar	lamellar	JJ
cord-005941-e4fvj54l	243	12	bodies	body	NNS
cord-005941-e4fvj54l	243	13	and	and	CC
cord-005941-e4fvj54l	243	14	inhibited	inhibit	VBN
cord-005941-e4fvj54l	243	15	proper	proper	JJ
cord-005941-e4fvj54l	243	16	unfolding	unfolding	NN
cord-005941-e4fvj54l	243	17	of	of	IN
cord-005941-e4fvj54l	243	18	secreted	secrete	VBN
cord-005941-e4fvj54l	243	19	lamellar	lamellar	JJ
cord-005941-e4fvj54l	243	20	body	body	NN
cord-005941-e4fvj54l	243	21	membranes	membrane	NNS
cord-005941-e4fvj54l	243	22	in	in	IN
cord-005941-e4fvj54l	243	23	the	the	DT
cord-005941-e4fvj54l	243	24	alveolar	alveolar	JJ
cord-005941-e4fvj54l	243	25	space	space	NN
cord-005941-e4fvj54l	243	26	[	[	-LRB-
cord-005941-e4fvj54l	243	27	6	6	CD
cord-005941-e4fvj54l	243	28	]	]	-RRB-
cord-005941-e4fvj54l	243	29	.	.	.
cord-005941-e4fvj54l	244	1	In	in	IN
cord-005941-e4fvj54l	244	2	vitro	vitro	FW
cord-005941-e4fvj54l	244	3	ozone	ozone	NN
cord-005941-e4fvj54l	244	4	exposure	exposure	NN
cord-005941-e4fvj54l	244	5	of	of	IN
cord-005941-e4fvj54l	244	6	SP	SP	NNP
cord-005941-e4fvj54l	244	7	-	-	HYPH
cord-005941-e4fvj54l	244	8	A	A	NNP
cord-005941-e4fvj54l	244	9	led	lead	VBN
cord-005941-e4fvj54l	244	10	to	to	IN
cord-005941-e4fvj54l	244	11	impairments	impairment	NNS
cord-005941-e4fvj54l	244	12	of	of	IN
cord-005941-e4fvj54l	244	13	important	important	JJ
cord-005941-e4fvj54l	244	14	physiologic	physiologic	JJ
cord-005941-e4fvj54l	244	15	SP	sp	NN
cord-005941-e4fvj54l	244	16	-	-	HYPH
cord-005941-e4fvj54l	244	17	A	A	NNP
cord-005941-e4fvj54l	244	18	functions	function	NNS
cord-005941-e4fvj54l	244	19	like	like	IN
cord-005941-e4fvj54l	244	20	self	self	NN
cord-005941-e4fvj54l	244	21	-	-	HYPH
cord-005941-e4fvj54l	244	22	association	association	NN
cord-005941-e4fvj54l	244	23	and	and	CC
cord-005941-e4fvj54l	244	24	SP	SP	NNP
cord-005941-e4fvj54l	244	25	-	-	HYPH
cord-005941-e4fvj54l	244	26	A	A	NNP
cord-005941-e4fvj54l	244	27	-	-	HYPH
cord-005941-e4fvj54l	244	28	mediated	mediate	VBN
cord-005941-e4fvj54l	244	29	lipid	lipid	NN
cord-005941-e4fvj54l	244	30	aggregation	aggregation	NN
cord-005941-e4fvj54l	244	31	[	[	-LRB-
cord-005941-e4fvj54l	244	32	132	132	CD
cord-005941-e4fvj54l	244	33	]	]	-RRB-
cord-005941-e4fvj54l	244	34	.	.	.
cord-005941-e4fvj54l	245	1	These	these	DT
cord-005941-e4fvj54l	245	2	studies	study	NNS
cord-005941-e4fvj54l	245	3	sugest	sugest	VBP
cord-005941-e4fvj54l	245	4	that	that	IN
cord-005941-e4fvj54l	245	5	ozone	ozone	NN
cord-005941-e4fvj54l	245	6	even	even	RB
cord-005941-e4fvj54l	245	7	at	at	IN
cord-005941-e4fvj54l	245	8	low	low	JJ
cord-005941-e4fvj54l	245	9	levels	level	NNS
cord-005941-e4fvj54l	245	10	leads	lead	VBZ
cord-005941-e4fvj54l	245	11	to	to	IN
cord-005941-e4fvj54l	245	12	changes	change	NNS
cord-005941-e4fvj54l	245	13	in	in	IN
cord-005941-e4fvj54l	245	14	surfactant	surfactant	NN
cord-005941-e4fvj54l	245	15	metabolism	metabolism	NN
cord-005941-e4fvj54l	245	16	and	and	CC
cord-005941-e4fvj54l	245	17	secretion	secretion	NN
cord-005941-e4fvj54l	245	18	and	and	CC
cord-005941-e4fvj54l	245	19	to	to	IN
cord-005941-e4fvj54l	245	20	alterations	alteration	NNS
cord-005941-e4fvj54l	245	21	of	of	IN
cord-005941-e4fvj54l	245	22	composition	composition	NN
cord-005941-e4fvj54l	245	23	and	and	CC
cord-005941-e4fvj54l	245	24	properties	property	NNS
cord-005941-e4fvj54l	245	25	of	of	IN
cord-005941-e4fvj54l	245	26	the	the	DT
cord-005941-e4fvj54l	245	27	secreted	secrete	VBN
cord-005941-e4fvj54l	245	28	surfactant	surfactant	NN
cord-005941-e4fvj54l	245	29	material	material	NN
cord-005941-e4fvj54l	245	30	.	.	.
cord-005941-e4fvj54l	246	1	Thus	thus	RB
cord-005941-e4fvj54l	246	2	,	,	,
cord-005941-e4fvj54l	246	3	it	-PRON-	PRP
cord-005941-e4fvj54l	246	4	seems	seem	VBZ
cord-005941-e4fvj54l	246	5	likely	likely	JJ
cord-005941-e4fvj54l	246	6	that	that	IN
cord-005941-e4fvj54l	246	7	the	the	DT
cord-005941-e4fvj54l	246	8	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	246	9	toxicity	toxicity	NN
cord-005941-e4fvj54l	246	10	of	of	IN
cord-005941-e4fvj54l	246	11	ozone	ozone	NN
cord-005941-e4fvj54l	246	12	is	be	VBZ
cord-005941-e4fvj54l	246	13	in	in	IN
cord-005941-e4fvj54l	246	14	part	part	NN
cord-005941-e4fvj54l	246	15	due	due	IN
cord-005941-e4fvj54l	246	16	to	to	IN
cord-005941-e4fvj54l	246	17	impairment	impairment	NN
cord-005941-e4fvj54l	246	18	of	of	IN
cord-005941-e4fvj54l	246	19	the	the	DT
cord-005941-e4fvj54l	246	20	surfacrant	surfacrant	JJ
cord-005941-e4fvj54l	246	21	system	system	NN
cord-005941-e4fvj54l	246	22	.	.	.
cord-005941-e4fvj54l	247	1	One	one	CD
cord-005941-e4fvj54l	247	2	of	of	IN
cord-005941-e4fvj54l	247	3	the	the	DT
cord-005941-e4fvj54l	247	4	many	many	JJ
cord-005941-e4fvj54l	247	5	remaining	remain	VBG
cord-005941-e4fvj54l	247	6	questions	question	NNS
cord-005941-e4fvj54l	247	7	is	be	VBZ
cord-005941-e4fvj54l	247	8	whether	whether	IN
cord-005941-e4fvj54l	247	9	ozone	ozone	NN
cord-005941-e4fvj54l	247	10	-	-	HYPH
cord-005941-e4fvj54l	247	11	induced	induce	VBN
cord-005941-e4fvj54l	247	12	surfactant	surfactant	NN
cord-005941-e4fvj54l	247	13	abnormalities	abnormality	NNS
cord-005941-e4fvj54l	247	14	are	be	VBP
cord-005941-e4fvj54l	247	15	also	also	RB
cord-005941-e4fvj54l	247	16	involved	involve	VBN
cord-005941-e4fvj54l	247	17	in	in	IN
cord-005941-e4fvj54l	247	18	the	the	DT
cord-005941-e4fvj54l	247	19	increased	increase	VBN
cord-005941-e4fvj54l	247	20	susceptibility	susceptibility	NN
cord-005941-e4fvj54l	247	21	to	to	IN
cord-005941-e4fvj54l	247	22	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	247	23	infections	infection	NNS
cord-005941-e4fvj54l	247	24	of	of	IN
cord-005941-e4fvj54l	247	25	chronically	chronically	RB
cord-005941-e4fvj54l	247	26	exposed	expose	VBN
cord-005941-e4fvj54l	247	27	individuals	individual	NNS
cord-005941-e4fvj54l	247	28	.	.	.
cord-005941-e4fvj54l	248	1	The	the	DT
cord-005941-e4fvj54l	248	2	majority	majority	NN
cord-005941-e4fvj54l	248	3	of	of	IN
cord-005941-e4fvj54l	248	4	atmospheric	atmospheric	JJ
cord-005941-e4fvj54l	248	5	nitrogen	nitrogen	NN
cord-005941-e4fvj54l	248	6	oxides	oxide	NNS
cord-005941-e4fvj54l	248	7	is	be	VBZ
cord-005941-e4fvj54l	248	8	derived	derive	VBN
cord-005941-e4fvj54l	248	9	from	from	IN
cord-005941-e4fvj54l	248	10	natural	natural	JJ
cord-005941-e4fvj54l	248	11	sources	source	NNS
cord-005941-e4fvj54l	248	12	.	.	.
cord-005941-e4fvj54l	249	1	However	however	RB
cord-005941-e4fvj54l	249	2	,	,	,
cord-005941-e4fvj54l	249	3	in	in	IN
cord-005941-e4fvj54l	249	4	urban	urban	JJ
cord-005941-e4fvj54l	249	5	areas	area	NNS
cord-005941-e4fvj54l	249	6	,	,	,
cord-005941-e4fvj54l	249	7	nitrogen	nitrogen	NN
cord-005941-e4fvj54l	249	8	oxides	oxide	NNS
cord-005941-e4fvj54l	249	9	from	from	IN
cord-005941-e4fvj54l	249	10	energy	energy	NN
cord-005941-e4fvj54l	249	11	utilization	utilization	NN
cord-005941-e4fvj54l	249	12	largely	largely	RB
cord-005941-e4fvj54l	249	13	determine	determine	VBP
cord-005941-e4fvj54l	249	14	air	air	NN
cord-005941-e4fvj54l	249	15	pollution	pollution	NN
cord-005941-e4fvj54l	249	16	levels	level	NNS
cord-005941-e4fvj54l	249	17	with	with	IN
cord-005941-e4fvj54l	249	18	these	these	DT
cord-005941-e4fvj54l	249	19	gases	gas	NNS
cord-005941-e4fvj54l	249	20	[	[	-LRB-
cord-005941-e4fvj54l	249	21	123	123	CD
cord-005941-e4fvj54l	249	22	]	]	-RRB-
cord-005941-e4fvj54l	249	23	.	.	.
cord-005941-e4fvj54l	250	1	The	the	DT
cord-005941-e4fvj54l	250	2	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	250	3	toxicity	toxicity	NN
cord-005941-e4fvj54l	250	4	of	of	IN
cord-005941-e4fvj54l	250	5	nitrogen	nitrogen	NN
cord-005941-e4fvj54l	250	6	dioxide	dioxide	NN
cord-005941-e4fvj54l	250	7	is	be	VBZ
cord-005941-e4fvj54l	250	8	similar	similar	JJ
cord-005941-e4fvj54l	250	9	to	to	IN
cord-005941-e4fvj54l	250	10	that	that	DT
cord-005941-e4fvj54l	250	11	of	of	IN
cord-005941-e4fvj54l	250	12	ozone	ozone	NN
cord-005941-e4fvj54l	250	13	,	,	,
cord-005941-e4fvj54l	250	14	inducing	induce	VBG
cord-005941-e4fvj54l	250	15	free	free	JJ
cord-005941-e4fvj54l	250	16	radical	radical	JJ
cord-005941-e4fvj54l	250	17	reactions	reaction	NNS
cord-005941-e4fvj54l	250	18	and	and	CC
cord-005941-e4fvj54l	250	19	lipid	lipid	NN
cord-005941-e4fvj54l	250	20	autoxidation	autoxidation	NN
cord-005941-e4fvj54l	250	21	[	[	-LRB-
cord-005941-e4fvj54l	250	22	55	55	CD
cord-005941-e4fvj54l	250	23	]	]	-RRB-
cord-005941-e4fvj54l	250	24	.	.	.
cord-005941-e4fvj54l	251	1	Probably	probably	RB
cord-005941-e4fvj54l	251	2	,	,	,
cord-005941-e4fvj54l	251	3	both	both	CC
cord-005941-e4fvj54l	251	4	these	these	DT
cord-005941-e4fvj54l	251	5	air	air	NN
cord-005941-e4fvj54l	251	6	pollutants	pollutant	NNS
cord-005941-e4fvj54l	251	7	have	have	VBP
cord-005941-e4fvj54l	251	8	synergistic	synergistic	JJ
cord-005941-e4fvj54l	251	9	toxic	toxic	JJ
cord-005941-e4fvj54l	251	10	effects	effect	NNS
cord-005941-e4fvj54l	251	11	on	on	IN
cord-005941-e4fvj54l	251	12	the	the	DT
cord-005941-e4fvj54l	251	13	lung	lung	NN
cord-005941-e4fvj54l	251	14	.	.	.
cord-005941-e4fvj54l	252	1	Short	short	JJ
cord-005941-e4fvj54l	252	2	-	-	HYPH
cord-005941-e4fvj54l	252	3	term	term	NN
cord-005941-e4fvj54l	252	4	exposure	exposure	NN
cord-005941-e4fvj54l	252	5	(	(	-LRB-
cord-005941-e4fvj54l	252	6	5	5	CD
cord-005941-e4fvj54l	252	7	h	h	NN
cord-005941-e4fvj54l	252	8	)	)	-RRB-
cord-005941-e4fvj54l	252	9	of	of	IN
cord-005941-e4fvj54l	252	10	rats	rat	NNS
cord-005941-e4fvj54l	252	11	to	to	IN
cord-005941-e4fvj54l	252	12	high	high	JJ
cord-005941-e4fvj54l	252	13	levels	level	NNS
cord-005941-e4fvj54l	252	14	(	(	-LRB-
cord-005941-e4fvj54l	252	15	40	40	CD
cord-005941-e4fvj54l	252	16	ppm	ppm	NN
cord-005941-e4fvj54l	252	17	)	)	-RRB-
cord-005941-e4fvj54l	252	18	of	of	IN
cord-005941-e4fvj54l	252	19	nitrogen	nitrogen	NN
cord-005941-e4fvj54l	252	20	dioxide	dioxide	NN
cord-005941-e4fvj54l	252	21	resulted	result	VBD
cord-005941-e4fvj54l	252	22	in	in	IN
cord-005941-e4fvj54l	252	23	phosphatidylcholine	phosphatidylcholine	NN
cord-005941-e4fvj54l	252	24	and	and	CC
cord-005941-e4fvj54l	252	25	phosphatidylglycerol	phosphatidylglycerol	JJ
cord-005941-e4fvj54l	252	26	accumulation	accumulation	NN
cord-005941-e4fvj54l	252	27	in	in	IN
cord-005941-e4fvj54l	252	28	lung	lung	NN
cord-005941-e4fvj54l	252	29	tissue	tissue	NN
cord-005941-e4fvj54l	252	30	with	with	IN
cord-005941-e4fvj54l	252	31	a	a	DT
cord-005941-e4fvj54l	252	32	peak	peak	NN
cord-005941-e4fvj54l	252	33	at	at	IN
cord-005941-e4fvj54l	252	34	48	48	CD
cord-005941-e4fvj54l	252	35	h	h	NN
cord-005941-e4fvj54l	252	36	postexposure	postexposure	NN
cord-005941-e4fvj54l	252	37	.	.	.
cord-005941-e4fvj54l	253	1	Incorporation	Incorporation	NNP
cord-005941-e4fvj54l	253	2	studies	study	NNS
cord-005941-e4fvj54l	253	3	suggested	suggest	VBD
cord-005941-e4fvj54l	253	4	that	that	IN
cord-005941-e4fvj54l	253	5	this	this	DT
cord-005941-e4fvj54l	253	6	increase	increase	NN
cord-005941-e4fvj54l	253	7	was	be	VBD
cord-005941-e4fvj54l	253	8	due	due	JJ
cord-005941-e4fvj54l	253	9	to	to	IN
cord-005941-e4fvj54l	253	10	enhanced	enhance	VBN
cord-005941-e4fvj54l	253	11	phospholipid	phospholipid	NN
cord-005941-e4fvj54l	253	12	synthesis	synthesis	NN
cord-005941-e4fvj54l	253	13	[	[	-LRB-
cord-005941-e4fvj54l	253	14	14	14	CD
cord-005941-e4fvj54l	253	15	]	]	-RRB-
cord-005941-e4fvj54l	253	16	.	.	.
cord-005941-e4fvj54l	254	1	Long	long	JJ
cord-005941-e4fvj54l	254	2	-	-	HYPH
cord-005941-e4fvj54l	254	3	term	term	NN
cord-005941-e4fvj54l	254	4	exposure	exposure	NN
cord-005941-e4fvj54l	254	5	(	(	-LRB-
cord-005941-e4fvj54l	254	6	9	9	CD
cord-005941-e4fvj54l	254	7	months	month	NNS
cord-005941-e4fvj54l	254	8	)	)	-RRB-
cord-005941-e4fvj54l	254	9	to	to	IN
cord-005941-e4fvj54l	254	10	low	low	JJ
cord-005941-e4fvj54l	254	11	levels	level	NNS
cord-005941-e4fvj54l	254	12	(	(	-LRB-
cord-005941-e4fvj54l	254	13	2.9	2.9	CD
cord-005941-e4fvj54l	254	14	ppm	ppm	NN
cord-005941-e4fvj54l	254	15	)	)	-RRB-
cord-005941-e4fvj54l	254	16	,	,	,
cord-005941-e4fvj54l	254	17	by	by	IN
cord-005941-e4fvj54l	254	18	contrast	contrast	NN
cord-005941-e4fvj54l	254	19	,	,	,
cord-005941-e4fvj54l	254	20	led	lead	VBD
cord-005941-e4fvj54l	254	21	645	645	CD
cord-005941-e4fvj54l	254	22	to	to	IN
cord-005941-e4fvj54l	254	23	a	a	DT
cord-005941-e4fvj54l	254	24	significant	significant	JJ
cord-005941-e4fvj54l	254	25	decrease	decrease	NN
cord-005941-e4fvj54l	254	26	in	in	IN
cord-005941-e4fvj54l	254	27	the	the	DT
cord-005941-e4fvj54l	254	28	lung	lung	NN
cord-005941-e4fvj54l	254	29	lipid	lipid	NN
cord-005941-e4fvj54l	254	30	content	content	NN
cord-005941-e4fvj54l	254	31	and	and	CC
cord-005941-e4fvj54l	254	32	changes	change	NNS
cord-005941-e4fvj54l	254	33	in	in	IN
cord-005941-e4fvj54l	254	34	the	the	DT
cord-005941-e4fvj54l	254	35	phospholipid	phospholipid	NN
cord-005941-e4fvj54l	254	36	fatty	fatty	JJ
cord-005941-e4fvj54l	254	37	acid	acid	NN
cord-005941-e4fvj54l	254	38	composition	composition	NN
cord-005941-e4fvj54l	254	39	[	[	-LRB-
cord-005941-e4fvj54l	254	40	2	2	CD
cord-005941-e4fvj54l	254	41	]	]	-RRB-
cord-005941-e4fvj54l	254	42	.	.	.
cord-005941-e4fvj54l	255	1	These	these	DT
cord-005941-e4fvj54l	255	2	studies	study	NNS
cord-005941-e4fvj54l	255	3	may	may	MD
cord-005941-e4fvj54l	255	4	indicate	indicate	VB
cord-005941-e4fvj54l	255	5	that	that	IN
cord-005941-e4fvj54l	255	6	the	the	DT
cord-005941-e4fvj54l	255	7	acute	acute	JJ
cord-005941-e4fvj54l	255	8	effect	effect	NN
cord-005941-e4fvj54l	255	9	of	of	IN
cord-005941-e4fvj54l	255	10	nitrogen	nitrogen	NN
cord-005941-e4fvj54l	255	11	dioxide	dioxide	NN
cord-005941-e4fvj54l	255	12	on	on	IN
cord-005941-e4fvj54l	255	13	alveolar	alveolar	NN
cord-005941-e4fvj54l	255	14	type	type	NN
cord-005941-e4fvj54l	255	15	II	II	NNP
cord-005941-e4fvj54l	255	16	cells	cell	NNS
cord-005941-e4fvj54l	255	17	is	be	VBZ
cord-005941-e4fvj54l	255	18	enhanced	enhance	VBN
cord-005941-e4fvj54l	255	19	surfactant	surfactant	NN
cord-005941-e4fvj54l	255	20	lipid	lipid	NN
cord-005941-e4fvj54l	255	21	synthesis	synthesis	NN
cord-005941-e4fvj54l	255	22	,	,	,
cord-005941-e4fvj54l	255	23	while	while	IN
cord-005941-e4fvj54l	255	24	chronic	chronic	JJ
cord-005941-e4fvj54l	255	25	low	low	JJ
cord-005941-e4fvj54l	255	26	-	-	HYPH
cord-005941-e4fvj54l	255	27	dose	dose	NN
cord-005941-e4fvj54l	255	28	exposure	exposure	NN
cord-005941-e4fvj54l	255	29	leads	lead	VBZ
cord-005941-e4fvj54l	255	30	to	to	IN
cord-005941-e4fvj54l	255	31	a	a	DT
cord-005941-e4fvj54l	255	32	decrease	decrease	NN
cord-005941-e4fvj54l	255	33	in	in	IN
cord-005941-e4fvj54l	255	34	surfactant	surfactant	NN
cord-005941-e4fvj54l	255	35	synthesis	synthesis	NN
cord-005941-e4fvj54l	255	36	capacity	capacity	NN
cord-005941-e4fvj54l	255	37	.	.	.
cord-005941-e4fvj54l	256	1	However	however	RB
cord-005941-e4fvj54l	256	2	,	,	,
cord-005941-e4fvj54l	256	3	the	the	DT
cord-005941-e4fvj54l	256	4	evidence	evidence	NN
cord-005941-e4fvj54l	256	5	is	be	VBZ
cord-005941-e4fvj54l	256	6	still	still	RB
cord-005941-e4fvj54l	256	7	scarce	scarce	JJ
cord-005941-e4fvj54l	256	8	and	and	CC
cord-005941-e4fvj54l	257	1	not	not	RB
cord-005941-e4fvj54l	257	2	all	all	DT
cord-005941-e4fvj54l	257	3	observed	observe	VBN
cord-005941-e4fvj54l	257	4	phospholipid	phospholipid	NN
cord-005941-e4fvj54l	257	5	changes	change	NNS
cord-005941-e4fvj54l	257	6	are	be	VBP
cord-005941-e4fvj54l	257	7	necessarily	necessarily	RB
cord-005941-e4fvj54l	257	8	related	relate	VBN
cord-005941-e4fvj54l	257	9	to	to	IN
cord-005941-e4fvj54l	257	10	the	the	DT
cord-005941-e4fvj54l	257	11	surfactant	surfactant	NN
cord-005941-e4fvj54l	257	12	system	system	NN
cord-005941-e4fvj54l	257	13	.	.	.
cord-005941-e4fvj54l	258	1	Further	further	JJ
cord-005941-e4fvj54l	258	2	studies	study	NNS
cord-005941-e4fvj54l	258	3	are	be	VBP
cord-005941-e4fvj54l	258	4	necessary	necessary	JJ
cord-005941-e4fvj54l	258	5	to	to	TO
cord-005941-e4fvj54l	258	6	define	define	VB
cord-005941-e4fvj54l	258	7	more	more	RBR
cord-005941-e4fvj54l	258	8	precisely	precisely	RB
cord-005941-e4fvj54l	258	9	the	the	DT
cord-005941-e4fvj54l	258	10	possible	possible	JJ
cord-005941-e4fvj54l	258	11	impact	impact	NN
cord-005941-e4fvj54l	258	12	of	of	IN
cord-005941-e4fvj54l	258	13	nitrogen	nitrogen	NN
cord-005941-e4fvj54l	258	14	dioxide	dioxide	NN
cord-005941-e4fvj54l	258	15	on	on	IN
cord-005941-e4fvj54l	258	16	alveolar	alveolar	NN
cord-005941-e4fvj54l	258	17	type	type	NN
cord-005941-e4fvj54l	258	18	II	ii	CD
cord-005941-e4fvj54l	258	19	cells	cell	NNS
cord-005941-e4fvj54l	258	20	and	and	CC
cord-005941-e4fvj54l	258	21	surfactant	surfactant	NN
cord-005941-e4fvj54l	258	22	material	material	NN
cord-005941-e4fvj54l	258	23	.	.	.
cord-005941-e4fvj54l	259	1	Also	also	RB
cord-005941-e4fvj54l	259	2	,	,	,
cord-005941-e4fvj54l	259	3	in	in	IN
cord-005941-e4fvj54l	259	4	view	view	NN
cord-005941-e4fvj54l	259	5	of	of	IN
cord-005941-e4fvj54l	259	6	a	a	DT
cord-005941-e4fvj54l	259	7	more	more	RBR
cord-005941-e4fvj54l	259	8	realistic	realistic	JJ
cord-005941-e4fvj54l	259	9	approach	approach	NN
cord-005941-e4fvj54l	259	10	to	to	IN
cord-005941-e4fvj54l	259	11	urban	urban	JJ
cord-005941-e4fvj54l	259	12	air	air	NN
cord-005941-e4fvj54l	259	13	pollution	pollution	NN
cord-005941-e4fvj54l	259	14	,	,	,
cord-005941-e4fvj54l	259	15	it	-PRON-	PRP
cord-005941-e4fvj54l	259	16	seems	seem	VBZ
cord-005941-e4fvj54l	259	17	important	important	JJ
cord-005941-e4fvj54l	259	18	to	to	TO
cord-005941-e4fvj54l	259	19	learn	learn	VB
cord-005941-e4fvj54l	259	20	more	more	JJR
cord-005941-e4fvj54l	259	21	about	about	IN
cord-005941-e4fvj54l	259	22	the	the	DT
cord-005941-e4fvj54l	259	23	co	co	NN
cord-005941-e4fvj54l	259	24	-	-	NN
cord-005941-e4fvj54l	259	25	toxicity	toxicity	NN
cord-005941-e4fvj54l	259	26	of	of	IN
cord-005941-e4fvj54l	259	27	ozone	ozone	NN
cord-005941-e4fvj54l	259	28	and	and	CC
cord-005941-e4fvj54l	259	29	nitrogen	nitrogen	NN
cord-005941-e4fvj54l	259	30	dioxide	dioxide	NN
cord-005941-e4fvj54l	259	31	.	.	.
cord-005941-e4fvj54l	260	1	The	the	DT
cord-005941-e4fvj54l	260	2	toxicity	toxicity	NN
cord-005941-e4fvj54l	260	3	of	of	IN
cord-005941-e4fvj54l	260	4	hyperbaric	hyperbaric	NN
cord-005941-e4fvj54l	260	5	oxygen	oxygen	NN
cord-005941-e4fvj54l	260	6	or	or	CC
cord-005941-e4fvj54l	260	7	oxygen	oxygen	NN
cord-005941-e4fvj54l	260	8	at	at	IN
cord-005941-e4fvj54l	260	9	high	high	JJ
cord-005941-e4fvj54l	260	10	concentrations	concentration	NNS
cord-005941-e4fvj54l	260	11	is	be	VBZ
cord-005941-e4fvj54l	260	12	well	well	RB
cord-005941-e4fvj54l	260	13	-	-	HYPH
cord-005941-e4fvj54l	260	14	known	know	VBN
cord-005941-e4fvj54l	260	15	and	and	CC
cord-005941-e4fvj54l	260	16	represents	represent	VBZ
cord-005941-e4fvj54l	260	17	one	one	CD
cord-005941-e4fvj54l	260	18	of	of	IN
cord-005941-e4fvj54l	260	19	the	the	DT
cord-005941-e4fvj54l	260	20	problems	problem	NNS
cord-005941-e4fvj54l	260	21	of	of	IN
cord-005941-e4fvj54l	260	22	mechanical	mechanical	JJ
cord-005941-e4fvj54l	260	23	high	high	JJ
cord-005941-e4fvj54l	260	24	oxygen	oxygen	NN
cord-005941-e4fvj54l	260	25	ventilation	ventilation	NN
cord-005941-e4fvj54l	260	26	,	,	,
cord-005941-e4fvj54l	260	27	e.g.	e.g.	RB
cord-005941-e4fvj54l	260	28	,	,	,
cord-005941-e4fvj54l	260	29	in	in	IN
cord-005941-e4fvj54l	260	30	intensive	intensive	JJ
cord-005941-e4fvj54l	260	31	care	care	NN
cord-005941-e4fvj54l	260	32	units	unit	NNS
cord-005941-e4fvj54l	260	33	.	.	.
cord-005941-e4fvj54l	261	1	The	the	DT
cord-005941-e4fvj54l	261	2	toxic	toxic	JJ
cord-005941-e4fvj54l	261	3	effect	effect	NN
cord-005941-e4fvj54l	261	4	is	be	VBZ
cord-005941-e4fvj54l	261	5	due	due	JJ
cord-005941-e4fvj54l	261	6	to	to	IN
cord-005941-e4fvj54l	261	7	aggressive	aggressive	JJ
cord-005941-e4fvj54l	261	8	oxygen	oxygen	NN
cord-005941-e4fvj54l	261	9	-	-	HYPH
cord-005941-e4fvj54l	261	10	derived	derive	VBN
cord-005941-e4fvj54l	261	11	free	free	JJ
cord-005941-e4fvj54l	261	12	radicals	radical	NNS
cord-005941-e4fvj54l	261	13	which	which	WDT
cord-005941-e4fvj54l	261	14	attack	attack	VBP
cord-005941-e4fvj54l	261	15	various	various	JJ
cord-005941-e4fvj54l	261	16	cell	cell	NN
cord-005941-e4fvj54l	261	17	constituents	constituent	NNS
cord-005941-e4fvj54l	261	18	and	and	CC
cord-005941-e4fvj54l	261	19	probably	probably	RB
cord-005941-e4fvj54l	261	20	also	also	RB
cord-005941-e4fvj54l	261	21	the	the	DT
cord-005941-e4fvj54l	261	22	surfactant	surfactant	NN
cord-005941-e4fvj54l	261	23	system	system	NN
cord-005941-e4fvj54l	261	24	.	.	.
cord-005941-e4fvj54l	262	1	In	in	IN
cord-005941-e4fvj54l	262	2	detail	detail	NN
cord-005941-e4fvj54l	262	3	,	,	,
cord-005941-e4fvj54l	262	4	it	-PRON-	PRP
cord-005941-e4fvj54l	262	5	has	have	VBZ
cord-005941-e4fvj54l	262	6	been	be	VBN
cord-005941-e4fvj54l	262	7	found	find	VBN
cord-005941-e4fvj54l	262	8	that	that	IN
cord-005941-e4fvj54l	262	9	rabbits	rabbit	NNS
cord-005941-e4fvj54l	262	10	exposed	expose	VBN
cord-005941-e4fvj54l	262	11	to	to	IN
cord-005941-e4fvj54l	262	12	100	100	CD
cord-005941-e4fvj54l	262	13	%	%	NN
cord-005941-e4fvj54l	262	14	oxygen	oxygen	NN
cord-005941-e4fvj54l	262	15	for	for	IN
cord-005941-e4fvj54l	262	16	64	64	CD
cord-005941-e4fvj54l	262	17	h	h	NN
cord-005941-e4fvj54l	262	18	exhibited	exhibit	VBD
cord-005941-e4fvj54l	262	19	a	a	DT
cord-005941-e4fvj54l	262	20	marked	marked	JJ
cord-005941-e4fvj54l	262	21	decrease	decrease	NN
cord-005941-e4fvj54l	262	22	in	in	IN
cord-005941-e4fvj54l	262	23	phosphatidylcholine	phosphatidylcholine	NN
cord-005941-e4fvj54l	262	24	synthesis	synthesis	NN
cord-005941-e4fvj54l	262	25	and	and	CC
cord-005941-e4fvj54l	262	26	cell	cell	NN
cord-005941-e4fvj54l	262	27	lipid	lipid	NN
cord-005941-e4fvj54l	262	28	content	content	NN
cord-005941-e4fvj54l	262	29	followed	follow	VBN
cord-005941-e4fvj54l	262	30	by	by	IN
cord-005941-e4fvj54l	262	31	a	a	DT
cord-005941-e4fvj54l	262	32	recovery	recovery	NN
cord-005941-e4fvj54l	262	33	to	to	IN
cord-005941-e4fvj54l	262	34	normal	normal	JJ
cord-005941-e4fvj54l	262	35	patterns	pattern	NNS
cord-005941-e4fvj54l	262	36	and	and	CC
cord-005941-e4fvj54l	262	37	subsequently	subsequently	RB
cord-005941-e4fvj54l	262	38	supranormal	supranormal	JJ
cord-005941-e4fvj54l	262	39	levels	level	NNS
cord-005941-e4fvj54l	262	40	beginning	begin	VBG
cord-005941-e4fvj54l	262	41	3	3	CD
cord-005941-e4fvj54l	262	42	days	day	NNS
cord-005941-e4fvj54l	262	43	postexposure	postexposure	NN
cord-005941-e4fvj54l	262	44	[	[	-LRB-
cord-005941-e4fvj54l	262	45	74	74	CD
cord-005941-e4fvj54l	262	46	]	]	-RRB-
cord-005941-e4fvj54l	262	47	.	.	.
cord-005941-e4fvj54l	263	1	The	the	DT
cord-005941-e4fvj54l	263	2	same	same	JJ
cord-005941-e4fvj54l	263	3	group	group	NN
cord-005941-e4fvj54l	263	4	[	[	-LRB-
cord-005941-e4fvj54l	263	5	114	114	CD
cord-005941-e4fvj54l	263	6	]	]	-RRB-
cord-005941-e4fvj54l	263	7	showed	show	VBD
cord-005941-e4fvj54l	263	8	that	that	IN
cord-005941-e4fvj54l	263	9	intratracheal	intratracheal	NN
cord-005941-e4fvj54l	263	10	surfactant	surfactant	NN
cord-005941-e4fvj54l	263	11	substitution	substitution	NN
cord-005941-e4fvj54l	263	12	significantly	significantly	RB
cord-005941-e4fvj54l	263	13	diminished	diminish	VBD
cord-005941-e4fvj54l	263	14	the	the	DT
cord-005941-e4fvj54l	263	15	progression	progression	NN
cord-005941-e4fvj54l	263	16	of	of	IN
cord-005941-e4fvj54l	263	17	hyperoxic	hyperoxic	JJ
cord-005941-e4fvj54l	263	18	injury	injury	NN
cord-005941-e4fvj54l	263	19	.	.	.
cord-005941-e4fvj54l	264	1	In	in	IN
cord-005941-e4fvj54l	264	2	rats	rat	NNS
cord-005941-e4fvj54l	264	3	exposed	expose	VBN
cord-005941-e4fvj54l	264	4	to	to	IN
cord-005941-e4fvj54l	264	5	85	85	CD
cord-005941-e4fvj54l	264	6	%	%	NN
cord-005941-e4fvj54l	264	7	oxygen	oxygen	NN
cord-005941-e4fvj54l	264	8	for	for	IN
cord-005941-e4fvj54l	264	9	72	72	CD
cord-005941-e4fvj54l	264	10	h	h	NN
cord-005941-e4fvj54l	264	11	,	,	,
cord-005941-e4fvj54l	264	12	increased	increase	VBN
cord-005941-e4fvj54l	264	13	levels	level	NNS
cord-005941-e4fvj54l	264	14	of	of	IN
cord-005941-e4fvj54l	264	15	phosphatidylcholine	phosphatidylcholine	NN
cord-005941-e4fvj54l	264	16	and	and	CC
cord-005941-e4fvj54l	264	17	SP	SP	NNP
cord-005941-e4fvj54l	264	18	-	-	HYPH
cord-005941-e4fvj54l	264	19	A	A	NNP
cord-005941-e4fvj54l	264	20	were	be	VBD
cord-005941-e4fvj54l	264	21	found	find	VBN
cord-005941-e4fvj54l	264	22	in	in	IN
cord-005941-e4fvj54l	264	23	lung	lung	NN
cord-005941-e4fvj54l	264	24	lavages	lavage	NNS
cord-005941-e4fvj54l	264	25	[	[	-LRB-
cord-005941-e4fvj54l	264	26	1261	1261	CD
cord-005941-e4fvj54l	264	27	.	.	.
cord-005941-e4fvj54l	265	1	It	-PRON-	PRP
cord-005941-e4fvj54l	265	2	was	be	VBD
cord-005941-e4fvj54l	265	3	concluded	conclude	VBN
cord-005941-e4fvj54l	265	4	that	that	IN
cord-005941-e4fvj54l	265	5	hyperoxic	hyperoxic	NNP
cord-005941-e4fvj54l	265	6	lung	lung	NN
cord-005941-e4fvj54l	265	7	injury	injury	NN
cord-005941-e4fvj54l	265	8	is	be	VBZ
cord-005941-e4fvj54l	265	9	not	not	RB
cord-005941-e4fvj54l	265	10	due	due	JJ
cord-005941-e4fvj54l	265	11	to	to	IN
cord-005941-e4fvj54l	265	12	intraalveolar	intraalveolar	NNP
cord-005941-e4fvj54l	265	13	decreases	decrease	NNS
cord-005941-e4fvj54l	265	14	of	of	IN
cord-005941-e4fvj54l	265	15	these	these	DT
cord-005941-e4fvj54l	265	16	two	two	CD
cord-005941-e4fvj54l	265	17	major	major	JJ
cord-005941-e4fvj54l	265	18	surfactant	surfactant	NN
cord-005941-e4fvj54l	265	19	components	component	NNS
cord-005941-e4fvj54l	265	20	.	.	.
cord-005941-e4fvj54l	266	1	However	however	RB
cord-005941-e4fvj54l	266	2	,	,	,
cord-005941-e4fvj54l	266	3	in	in	IN
cord-005941-e4fvj54l	266	4	another	another	DT
cord-005941-e4fvj54l	266	5	animal	animal	NN
cord-005941-e4fvj54l	266	6	study	study	NN
cord-005941-e4fvj54l	266	7	DPPC	DPPC	NNP
cord-005941-e4fvj54l	266	8	was	be	VBD
cord-005941-e4fvj54l	266	9	decreased	decrease	VBN
cord-005941-e4fvj54l	266	10	and	and	CC
cord-005941-e4fvj54l	266	11	the	the	DT
cord-005941-e4fvj54l	266	12	PG	PG	NNP
cord-005941-e4fvj54l	266	13	:	:	:
cord-005941-e4fvj54l	267	1	PI	PI	NNP
cord-005941-e4fvj54l	267	2	ratio	ratio	NN
cord-005941-e4fvj54l	267	3	was	be	VBD
cord-005941-e4fvj54l	267	4	markedly	markedly	RB
cord-005941-e4fvj54l	267	5	lower	low	JJR
cord-005941-e4fvj54l	267	6	than	than	IN
cord-005941-e4fvj54l	267	7	baseline	baseline	JJ
cord-005941-e4fvj54l	267	8	values	value	NNS
cord-005941-e4fvj54l	267	9	after	after	IN
cord-005941-e4fvj54l	267	10	4	4	CD
cord-005941-e4fvj54l	267	11	-	-	SYM
cord-005941-e4fvj54l	267	12	5	5	CD
cord-005941-e4fvj54l	267	13	days	day	NNS
cord-005941-e4fvj54l	267	14	exposure	exposure	NN
cord-005941-e4fvj54l	267	15	to	to	IN
cord-005941-e4fvj54l	267	16	100	100	CD
cord-005941-e4fvj54l	267	17	%	%	NN
cord-005941-e4fvj54l	267	18	oxygen	oxygen	NN
cord-005941-e4fvj54l	267	19	.	.	.
cord-005941-e4fvj54l	268	1	Longer	long	JJR
cord-005941-e4fvj54l	268	2	periods	period	NNS
cord-005941-e4fvj54l	268	3	of	of	IN
cord-005941-e4fvj54l	268	4	exposure	exposure	NN
cord-005941-e4fvj54l	268	5	resulted	result	VBD
cord-005941-e4fvj54l	268	6	in	in	IN
cord-005941-e4fvj54l	268	7	a	a	DT
cord-005941-e4fvj54l	268	8	further	further	JJ
cord-005941-e4fvj54l	268	9	drop	drop	NN
cord-005941-e4fvj54l	268	10	of	of	IN
cord-005941-e4fvj54l	268	11	DPPC	DPPC	NNP
cord-005941-e4fvj54l	268	12	values	value	NNS
cord-005941-e4fvj54l	268	13	[	[	-LRB-
cord-005941-e4fvj54l	268	14	95	95	CD
cord-005941-e4fvj54l	268	15	]	]	-RRB-
cord-005941-e4fvj54l	268	16	.	.	.
cord-005941-e4fvj54l	269	1	Pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	269	2	oxygen	oxygen	NN
cord-005941-e4fvj54l	269	3	toxicity	toxicity	NN
cord-005941-e4fvj54l	269	4	does	do	VBZ
cord-005941-e4fvj54l	269	5	not	not	RB
cord-005941-e4fvj54l	269	6	seem	seem	VB
cord-005941-e4fvj54l	269	7	to	to	TO
cord-005941-e4fvj54l	269	8	be	be	VB
cord-005941-e4fvj54l	269	9	consistently	consistently	RB
cord-005941-e4fvj54l	269	10	related	relate	VBN
cord-005941-e4fvj54l	269	11	to	to	IN
cord-005941-e4fvj54l	269	12	changes	change	NNS
cord-005941-e4fvj54l	269	13	of	of	IN
cord-005941-e4fvj54l	269	14	surface	surface	NN
cord-005941-e4fvj54l	269	15	tension	tension	NN
cord-005941-e4fvj54l	269	16	measured	measure	VBN
cord-005941-e4fvj54l	269	17	in	in	IN
cord-005941-e4fvj54l	269	18	lung	lung	NN
cord-005941-e4fvj54l	269	19	lavage	lavage	NN
cord-005941-e4fvj54l	269	20	fluids	fluid	NNS
cord-005941-e4fvj54l	269	21	of	of	IN
cord-005941-e4fvj54l	269	22	exposed	expose	VBN
cord-005941-e4fvj54l	269	23	animals	animal	NNS
cord-005941-e4fvj54l	269	24	[	[	-LRB-
cord-005941-e4fvj54l	269	25	1	1	CD
cord-005941-e4fvj54l	269	26	]	]	-RRB-
cord-005941-e4fvj54l	269	27	.	.	.
cord-005941-e4fvj54l	270	1	In	in	IN
cord-005941-e4fvj54l	270	2	conclusion	conclusion	NN
cord-005941-e4fvj54l	270	3	,	,	,
cord-005941-e4fvj54l	270	4	hyperoxic	hyperoxic	NNP
cord-005941-e4fvj54l	270	5	lung	lung	NN
cord-005941-e4fvj54l	270	6	injury	injury	NN
cord-005941-e4fvj54l	270	7	may	may	MD
cord-005941-e4fvj54l	270	8	be	be	VB
cord-005941-e4fvj54l	270	9	associated	associate	VBN
cord-005941-e4fvj54l	270	10	with	with	IN
cord-005941-e4fvj54l	270	11	alveolar	alveolar	JJ
cord-005941-e4fvj54l	270	12	type	type	NN
cord-005941-e4fvj54l	270	13	II	ii	CD
cord-005941-e4fvj54l	270	14	cell	cell	NN
cord-005941-e4fvj54l	270	15	changes	change	NNS
cord-005941-e4fvj54l	270	16	in	in	IN
cord-005941-e4fvj54l	270	17	surfactant	surfactant	NN
cord-005941-e4fvj54l	270	18	biosynthesis	biosynthesis	NN
cord-005941-e4fvj54l	270	19	.	.	.
cord-005941-e4fvj54l	271	1	However	however	RB
cord-005941-e4fvj54l	271	2	,	,	,
cord-005941-e4fvj54l	271	3	different	different	JJ
cord-005941-e4fvj54l	271	4	studies	study	NNS
cord-005941-e4fvj54l	271	5	have	have	VBP
cord-005941-e4fvj54l	271	6	found	find	VBN
cord-005941-e4fvj54l	271	7	partly	partly	RB
cord-005941-e4fvj54l	271	8	conflicting	conflict	VBG
cord-005941-e4fvj54l	271	9	results	result	NNS
cord-005941-e4fvj54l	271	10	,	,	,
cord-005941-e4fvj54l	271	11	and	and	CC
cord-005941-e4fvj54l	271	12	the	the	DT
cord-005941-e4fvj54l	271	13	way	way	NN
cord-005941-e4fvj54l	271	14	in	in	IN
cord-005941-e4fvj54l	271	15	which	which	WDT
cord-005941-e4fvj54l	271	16	hyperoxic	hyperoxic	NNP
cord-005941-e4fvj54l	271	17	lung	lung	NN
cord-005941-e4fvj54l	271	18	injury	injury	NN
cord-005941-e4fvj54l	271	19	contributes	contribute	VBZ
cord-005941-e4fvj54l	271	20	to	to	IN
cord-005941-e4fvj54l	271	21	quantitative	quantitative	JJ
cord-005941-e4fvj54l	271	22	and	and	CC
cord-005941-e4fvj54l	271	23	functional	functional	JJ
cord-005941-e4fvj54l	271	24	changes	change	NNS
cord-005941-e4fvj54l	271	25	of	of	IN
cord-005941-e4fvj54l	271	26	alveolar	alveolar	NN
cord-005941-e4fvj54l	271	27	surfactant	surfactant	NN
cord-005941-e4fvj54l	271	28	is	be	VBZ
cord-005941-e4fvj54l	271	29	still	still	RB
cord-005941-e4fvj54l	271	30	poorly	poorly	RB
cord-005941-e4fvj54l	271	31	understood	understand	VBN
cord-005941-e4fvj54l	271	32	.	.	.
cord-005941-e4fvj54l	272	1	It	-PRON-	PRP
cord-005941-e4fvj54l	272	2	should	should	MD
cord-005941-e4fvj54l	272	3	also	also	RB
cord-005941-e4fvj54l	272	4	be	be	VB
cord-005941-e4fvj54l	272	5	remembered	remember	VBN
cord-005941-e4fvj54l	272	6	that	that	IN
cord-005941-e4fvj54l	272	7	the	the	DT
cord-005941-e4fvj54l	272	8	oxidant	oxidant	JJ
cord-005941-e4fvj54l	272	9	attack	attack	NN
cord-005941-e4fvj54l	272	10	of	of	IN
cord-005941-e4fvj54l	272	11	oxygen	oxygen	NN
cord-005941-e4fvj54l	272	12	is	be	VBZ
cord-005941-e4fvj54l	272	13	not	not	RB
cord-005941-e4fvj54l	272	14	limited	limit	VBN
cord-005941-e4fvj54l	272	15	to	to	IN
cord-005941-e4fvj54l	272	16	type	type	NN
cord-005941-e4fvj54l	272	17	II	ii	CD
cord-005941-e4fvj54l	272	18	cells	cell	NNS
cord-005941-e4fvj54l	272	19	or	or	CC
cord-005941-e4fvj54l	272	20	surfactant	surfactant	NN
cord-005941-e4fvj54l	272	21	,	,	,
cord-005941-e4fvj54l	272	22	and	and	CC
cord-005941-e4fvj54l	272	23	thus	thus	RB
cord-005941-e4fvj54l	272	24	,	,	,
cord-005941-e4fvj54l	272	25	some	some	DT
cord-005941-e4fvj54l	272	26	of	of	IN
cord-005941-e4fvj54l	272	27	the	the	DT
cord-005941-e4fvj54l	272	28	described	describe	VBN
cord-005941-e4fvj54l	272	29	phospholipid	phospholipid	NN
cord-005941-e4fvj54l	272	30	changes	change	NNS
cord-005941-e4fvj54l	272	31	may	may	MD
cord-005941-e4fvj54l	272	32	not	not	RB
cord-005941-e4fvj54l	272	33	exclusively	exclusively	RB
cord-005941-e4fvj54l	272	34	reflect	reflect	VB
cord-005941-e4fvj54l	272	35	surfactant	surfactant	NN
cord-005941-e4fvj54l	272	36	abnormalities	abnormality	NNS
cord-005941-e4fvj54l	272	37	.	.	.
cord-005941-e4fvj54l	273	1	Cigarette	cigarette	NN
cord-005941-e4fvj54l	273	2	smoke	smoke	NN
cord-005941-e4fvj54l	273	3	is	be	VBZ
cord-005941-e4fvj54l	273	4	a	a	DT
cord-005941-e4fvj54l	273	5	complex	complex	JJ
cord-005941-e4fvj54l	273	6	mixture	mixture	NN
cord-005941-e4fvj54l	273	7	of	of	IN
cord-005941-e4fvj54l	273	8	particles	particle	NNS
cord-005941-e4fvj54l	273	9	and	and	CC
cord-005941-e4fvj54l	273	10	gases	gas	NNS
cord-005941-e4fvj54l	273	11	.	.	.
cord-005941-e4fvj54l	274	1	A	a	DT
cord-005941-e4fvj54l	274	2	reduced	reduced	JJ
cord-005941-e4fvj54l	274	3	yield	yield	NN
cord-005941-e4fvj54l	274	4	of	of	IN
cord-005941-e4fvj54l	274	5	phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	274	6	from	from	IN
cord-005941-e4fvj54l	274	7	BAL	bal	NN
cord-005941-e4fvj54l	274	8	fluids	fluid	NNS
cord-005941-e4fvj54l	274	9	of	of	IN
cord-005941-e4fvj54l	274	10	smokers	smoker	NNS
cord-005941-e4fvj54l	274	11	compared	compare	VBN
cord-005941-e4fvj54l	274	12	with	with	IN
cord-005941-e4fvj54l	274	13	nonsmokers	nonsmoker	NNS
cord-005941-e4fvj54l	274	14	has	have	VBZ
cord-005941-e4fvj54l	274	15	been	be	VBN
cord-005941-e4fvj54l	274	16	described	describe	VBN
cord-005941-e4fvj54l	274	17	[	[	-LRB-
cord-005941-e4fvj54l	274	18	41	41	CD
cord-005941-e4fvj54l	274	19	]	]	-RRB-
cord-005941-e4fvj54l	274	20	.	.	.
cord-005941-e4fvj54l	275	1	This	this	DT
cord-005941-e4fvj54l	275	2	difference	difference	NN
cord-005941-e4fvj54l	275	3	was	be	VBD
cord-005941-e4fvj54l	275	4	interpreted	interpret	VBN
cord-005941-e4fvj54l	275	5	to	to	TO
cord-005941-e4fvj54l	275	6	be	be	VB
cord-005941-e4fvj54l	275	7	partly	partly	RB
cord-005941-e4fvj54l	275	8	due	due	JJ
cord-005941-e4fvj54l	275	9	to	to	IN
cord-005941-e4fvj54l	275	10	lower	low	JJR
cord-005941-e4fvj54l	275	11	lavage	lavage	NN
cord-005941-e4fvj54l	275	12	fluid	fluid	NN
cord-005941-e4fvj54l	275	13	recovery	recovery	NN
cord-005941-e4fvj54l	275	14	from	from	IN
cord-005941-e4fvj54l	275	15	smokers	smoker	NNS
cord-005941-e4fvj54l	275	16	related	relate	VBN
cord-005941-e4fvj54l	275	17	to	to	IN
cord-005941-e4fvj54l	275	18	their	-PRON-	PRP$
cord-005941-e4fvj54l	275	19	known	know	VBN
cord-005941-e4fvj54l	275	20	tendency	tendency	NN
cord-005941-e4fvj54l	275	21	to	to	TO
cord-005941-e4fvj54l	275	22	bronchoconstriction	bronchoconstriction	VB
cord-005941-e4fvj54l	275	23	.	.	.
cord-005941-e4fvj54l	276	1	Additionally	additionally	RB
cord-005941-e4fvj54l	276	2	,	,	,
cord-005941-e4fvj54l	276	3	it	-PRON-	PRP
cord-005941-e4fvj54l	276	4	was	be	VBD
cord-005941-e4fvj54l	276	5	thought	think	VBN
cord-005941-e4fvj54l	276	6	to	to	TO
cord-005941-e4fvj54l	276	7	reflect	reflect	VB
cord-005941-e4fvj54l	276	8	the	the	DT
cord-005941-e4fvj54l	276	9	enhanced	enhanced	JJ
cord-005941-e4fvj54l	276	10	phagocytosis	phagocytosis	NN
cord-005941-e4fvj54l	276	11	activity	activity	NN
cord-005941-e4fvj54l	276	12	of	of	IN
cord-005941-e4fvj54l	276	13	alveolar	alveolar	JJ
cord-005941-e4fvj54l	276	14	macrophages	macrophage	NNS
cord-005941-e4fvj54l	276	15	[	[	-LRB-
cord-005941-e4fvj54l	276	16	21	21	CD
cord-005941-e4fvj54l	276	17	]	]	-RRB-
cord-005941-e4fvj54l	276	18	.	.	.
cord-005941-e4fvj54l	277	1	Another	another	DT
cord-005941-e4fvj54l	277	2	group	group	NN
cord-005941-e4fvj54l	277	3	found	find	VBD
cord-005941-e4fvj54l	277	4	no	no	DT
cord-005941-e4fvj54l	277	5	such	such	JJ
cord-005941-e4fvj54l	277	6	quantitative	quantitative	JJ
cord-005941-e4fvj54l	277	7	differences	difference	NNS
cord-005941-e4fvj54l	277	8	between	between	IN
cord-005941-e4fvj54l	277	9	smokers	smoker	NNS
cord-005941-e4fvj54l	277	10	and	and	CC
cord-005941-e4fvj54l	277	11	nonsmokers	nonsmoker	NNS
cord-005941-e4fvj54l	277	12	but	but	CC
cord-005941-e4fvj54l	277	13	described	describe	VBD
cord-005941-e4fvj54l	277	14	a	a	DT
cord-005941-e4fvj54l	277	15	decreased	decrease	VBN
cord-005941-e4fvj54l	277	16	phospholipid	phospholipid	NN
cord-005941-e4fvj54l	277	17	/	/	SYM
cord-005941-e4fvj54l	277	18	protein	protein	NN
cord-005941-e4fvj54l	277	19	ratio	ratio	NN
cord-005941-e4fvj54l	277	20	in	in	IN
cord-005941-e4fvj54l	277	21	smokers	smoker	NNS
cord-005941-e4fvj54l	277	22	[	[	-LRB-
cord-005941-e4fvj54l	277	23	108	108	CD
cord-005941-e4fvj54l	277	24	]	]	-RRB-
cord-005941-e4fvj54l	277	25	.	.	.
cord-005941-e4fvj54l	278	1	In	in	IN
cord-005941-e4fvj54l	278	2	rats	rat	NNS
cord-005941-e4fvj54l	278	3	exposed	expose	VBN
cord-005941-e4fvj54l	278	4	to	to	IN
cord-005941-e4fvj54l	278	5	cigarette	cigarette	NN
cord-005941-e4fvj54l	278	6	smoke	smoke	NN
cord-005941-e4fvj54l	278	7	,	,	,
cord-005941-e4fvj54l	278	8	a	a	DT
cord-005941-e4fvj54l	278	9	decrease	decrease	NN
cord-005941-e4fvj54l	278	10	of	of	IN
cord-005941-e4fvj54l	278	11	surfactant	surfactant	NN
cord-005941-e4fvj54l	278	12	material	material	NN
cord-005941-e4fvj54l	278	13	in	in	IN
cord-005941-e4fvj54l	278	14	lung	lung	NN
cord-005941-e4fvj54l	278	15	lavages	lavage	NNS
cord-005941-e4fvj54l	278	16	was	be	VBD
cord-005941-e4fvj54l	278	17	found	find	VBN
cord-005941-e4fvj54l	278	18	.	.	.
cord-005941-e4fvj54l	279	1	Additionally	additionally	RB
cord-005941-e4fvj54l	279	2	,	,	,
cord-005941-e4fvj54l	279	3	a	a	DT
cord-005941-e4fvj54l	279	4	progressive	progressive	JJ
cord-005941-e4fvj54l	279	5	injury	injury	NN
cord-005941-e4fvj54l	279	6	of	of	IN
cord-005941-e4fvj54l	279	7	alveolar	alveolar	JJ
cord-005941-e4fvj54l	279	8	type	type	NN
cord-005941-e4fvj54l	279	9	II	ii	CD
cord-005941-e4fvj54l	279	10	cells	cell	NNS
cord-005941-e4fvj54l	279	11	was	be	VBD
cord-005941-e4fvj54l	279	12	observed	observe	VBN
cord-005941-e4fvj54l	279	13	over	over	IN
cord-005941-e4fvj54l	279	14	time	time	NN
cord-005941-e4fvj54l	279	15	as	as	IN
cord-005941-e4fvj54l	279	16	determined	determine	VBN
cord-005941-e4fvj54l	279	17	by	by	IN
cord-005941-e4fvj54l	279	18	electron	electron	NN
cord-005941-e4fvj54l	279	19	microscopy	microscopy	NNS
cord-005941-e4fvj54l	279	20	,	,	,
cord-005941-e4fvj54l	279	21	indicating	indicate	VBG
cord-005941-e4fvj54l	279	22	that	that	DT
cord-005941-e4fvj54l	279	23	type	type	NN
cord-005941-e4fvj54l	279	24	II	ii	CD
cord-005941-e4fvj54l	279	25	cells	cell	NNS
cord-005941-e4fvj54l	279	26	and	and	CC
cord-005941-e4fvj54l	279	27	therefore	therefore	RB
cord-005941-e4fvj54l	279	28	possibly	possibly	RB
cord-005941-e4fvj54l	279	29	the	the	DT
cord-005941-e4fvj54l	279	30	surfactant	surfactant	NN
cord-005941-e4fvj54l	279	31	system	system	NN
cord-005941-e4fvj54l	279	32	may	may	MD
cord-005941-e4fvj54l	279	33	be	be	VB
cord-005941-e4fvj54l	279	34	one	one	CD
cord-005941-e4fvj54l	279	35	of	of	IN
cord-005941-e4fvj54l	279	36	the	the	DT
cord-005941-e4fvj54l	279	37	targets	target	NNS
cord-005941-e4fvj54l	279	38	of	of	IN
cord-005941-e4fvj54l	279	39	cigarette	cigarette	NN
cord-005941-e4fvj54l	279	40	smoke	smoke	NN
cord-005941-e4fvj54l	279	41	in	in	IN
cord-005941-e4fvj54l	279	42	the	the	DT
cord-005941-e4fvj54l	279	43	peripheral	peripheral	JJ
cord-005941-e4fvj54l	279	44	lung	lung	NN
cord-005941-e4fvj54l	279	45	[	[	-LRB-
cord-005941-e4fvj54l	279	46	102	102	CD
cord-005941-e4fvj54l	279	47	]	]	-RRB-
cord-005941-e4fvj54l	279	48	.	.	.
cord-005941-e4fvj54l	280	1	In	in	IN
cord-005941-e4fvj54l	280	2	vitro	vitro	FW
cord-005941-e4fvj54l	280	3	studies	study	NNS
cord-005941-e4fvj54l	280	4	showed	show	VBD
cord-005941-e4fvj54l	280	5	that	that	IN
cord-005941-e4fvj54l	280	6	smoke	smoke	NN
cord-005941-e4fvj54l	280	7	particles	particle	NNS
cord-005941-e4fvj54l	280	8	but	but	CC
cord-005941-e4fvj54l	280	9	not	not	RB
cord-005941-e4fvj54l	280	10	the	the	DT
cord-005941-e4fvj54l	280	11	gas	gas	NN
cord-005941-e4fvj54l	280	12	phase	phase	NN
cord-005941-e4fvj54l	280	13	of	of	IN
cord-005941-e4fvj54l	280	14	cigarette	cigarette	NN
cord-005941-e4fvj54l	280	15	smoke	smoke	NN
cord-005941-e4fvj54l	280	16	interacted	interact	VBD
cord-005941-e4fvj54l	280	17	with	with	IN
cord-005941-e4fvj54l	280	18	a	a	DT
cord-005941-e4fvj54l	280	19	surface	surface	NN
cord-005941-e4fvj54l	280	20	film	film	NN
cord-005941-e4fvj54l	280	21	of	of	IN
cord-005941-e4fvj54l	280	22	surfactant	surfactant	NN
cord-005941-e4fvj54l	280	23	and	and	CC
cord-005941-e4fvj54l	280	24	altered	alter	VBD
cord-005941-e4fvj54l	280	25	its	-PRON-	PRP$
cord-005941-e4fvj54l	280	26	surface	surface	NN
cord-005941-e4fvj54l	280	27	active	active	JJ
cord-005941-e4fvj54l	280	28	properties	property	NNS
cord-005941-e4fvj54l	280	29	in	in	IN
cord-005941-e4fvj54l	280	30	such	such	PDT
cord-005941-e4fvj54l	280	31	a	a	DT
cord-005941-e4fvj54l	280	32	way	way	NN
cord-005941-e4fvj54l	280	33	that	that	WDT
cord-005941-e4fvj54l	280	34	the	the	DT
cord-005941-e4fvj54l	280	35	maximum	maximum	JJ
cord-005941-e4fvj54l	280	36	surface	surface	NN
cord-005941-e4fvj54l	280	37	area	area	NN
cord-005941-e4fvj54l	280	38	was	be	VBD
cord-005941-e4fvj54l	280	39	reduced	reduce	VBN
cord-005941-e4fvj54l	280	40	,	,	,
cord-005941-e4fvj54l	280	41	but	but	CC
cord-005941-e4fvj54l	280	42	the	the	DT
cord-005941-e4fvj54l	280	43	minimum	minimum	JJ
cord-005941-e4fvj54l	280	44	surface	surface	NN
cord-005941-e4fvj54l	280	45	tension	tension	NN
cord-005941-e4fvj54l	280	46	was	be	VBD
cord-005941-e4fvj54l	280	47	increased	increase	VBN
cord-005941-e4fvj54l	280	48	[	[	-LRB-
cord-005941-e4fvj54l	280	49	68	68	CD
cord-005941-e4fvj54l	280	50	]	]	-RRB-
cord-005941-e4fvj54l	280	51	.	.	.
cord-005941-e4fvj54l	281	1	This	this	DT
cord-005941-e4fvj54l	281	2	may	may	MD
cord-005941-e4fvj54l	281	3	possibly	possibly	RB
cord-005941-e4fvj54l	281	4	contribute	contribute	VB
cord-005941-e4fvj54l	281	5	to	to	IN
cord-005941-e4fvj54l	281	6	altered	alter	VBN
cord-005941-e4fvj54l	281	7	mechanical	mechanical	JJ
cord-005941-e4fvj54l	281	8	properties	property	NNS
cord-005941-e4fvj54l	281	9	of	of	IN
cord-005941-e4fvj54l	281	10	the	the	DT
cord-005941-e4fvj54l	281	11	lungs	lung	NNS
cord-005941-e4fvj54l	281	12	of	of	IN
cord-005941-e4fvj54l	281	13	smokers	smoker	NNS
cord-005941-e4fvj54l	281	14	.	.	.
cord-005941-e4fvj54l	282	1	In	in	IN
cord-005941-e4fvj54l	282	2	conclusion	conclusion	NN
cord-005941-e4fvj54l	282	3	,	,	,
cord-005941-e4fvj54l	282	4	only	only	RB
cord-005941-e4fvj54l	282	5	a	a	DT
cord-005941-e4fvj54l	282	6	few	few	JJ
cord-005941-e4fvj54l	282	7	studies	study	NNS
cord-005941-e4fvj54l	282	8	have	have	VBP
cord-005941-e4fvj54l	282	9	so	so	RB
cord-005941-e4fvj54l	282	10	far	far	RB
cord-005941-e4fvj54l	282	11	investigated	investigate	VBN
cord-005941-e4fvj54l	282	12	the	the	DT
cord-005941-e4fvj54l	282	13	possible	possible	JJ
cord-005941-e4fvj54l	282	14	impacts	impact	NNS
cord-005941-e4fvj54l	282	15	of	of	IN
cord-005941-e4fvj54l	282	16	cigarette	cigarette	NN
cord-005941-e4fvj54l	282	17	smoke	smoke	NN
cord-005941-e4fvj54l	282	18	on	on	IN
cord-005941-e4fvj54l	282	19	the	the	DT
cord-005941-e4fvj54l	282	20	surfactant	surfactant	NN
cord-005941-e4fvj54l	282	21	system	system	NN
cord-005941-e4fvj54l	282	22	.	.	.
cord-005941-e4fvj54l	283	1	Thus	thus	RB
cord-005941-e4fvj54l	283	2	,	,	,
cord-005941-e4fvj54l	283	3	our	-PRON-	PRP$
cord-005941-e4fvj54l	283	4	knowledge	knowledge	NN
cord-005941-e4fvj54l	283	5	about	about	IN
cord-005941-e4fvj54l	283	6	the	the	DT
cord-005941-e4fvj54l	283	7	effects	effect	NNS
cord-005941-e4fvj54l	283	8	of	of	IN
cord-005941-e4fvj54l	283	9	this	this	DT
cord-005941-e4fvj54l	283	10	important	important	JJ
cord-005941-e4fvj54l	283	11	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	283	12	toxicant	toxicant	NN
cord-005941-e4fvj54l	283	13	is	be	VBZ
cord-005941-e4fvj54l	283	14	still	still	RB
cord-005941-e4fvj54l	283	15	very	very	RB
cord-005941-e4fvj54l	283	16	fragmentary	fragmentary	JJ
cord-005941-e4fvj54l	283	17	and	and	CC
cord-005941-e4fvj54l	283	18	awaits	await	VBZ
cord-005941-e4fvj54l	283	19	further	further	JJ
cord-005941-e4fvj54l	283	20	investigations	investigation	NNS
cord-005941-e4fvj54l	283	21	.	.	.
cord-005941-e4fvj54l	284	1	Smoke	smoke	NN
cord-005941-e4fvj54l	284	2	generated	generate	VBN
cord-005941-e4fvj54l	284	3	from	from	IN
cord-005941-e4fvj54l	284	4	the	the	DT
cord-005941-e4fvj54l	284	5	burning	burning	NN
cord-005941-e4fvj54l	284	6	of	of	IN
cord-005941-e4fvj54l	284	7	polyurethane	polyurethane	NN
cord-005941-e4fvj54l	284	8	foam	foam	NN
cord-005941-e4fvj54l	284	9	has	have	VBZ
cord-005941-e4fvj54l	284	10	been	be	VBN
cord-005941-e4fvj54l	284	11	shown	show	VBN
cord-005941-e4fvj54l	284	12	to	to	TO
cord-005941-e4fvj54l	284	13	increase	increase	VB
cord-005941-e4fvj54l	284	14	significantly	significantly	RB
cord-005941-e4fvj54l	284	15	the	the	DT
cord-005941-e4fvj54l	284	16	total	total	JJ
cord-005941-e4fvj54l	284	17	phospholipid	phospholipid	NN
cord-005941-e4fvj54l	284	18	content	content	NN
cord-005941-e4fvj54l	284	19	of	of	IN
cord-005941-e4fvj54l	284	20	lung	lung	NN
cord-005941-e4fvj54l	284	21	lavages	lavage	NNS
cord-005941-e4fvj54l	284	22	from	from	IN
cord-005941-e4fvj54l	284	23	rats	rat	NNS
cord-005941-e4fvj54l	284	24	after	after	IN
cord-005941-e4fvj54l	284	25	short	short	JJ
cord-005941-e4fvj54l	284	26	-	-	HYPH
cord-005941-e4fvj54l	284	27	term	term	NN
cord-005941-e4fvj54l	284	28	exposure	exposure	NN
cord-005941-e4fvj54l	284	29	[	[	-LRB-
cord-005941-e4fvj54l	284	30	134	134	CD
cord-005941-e4fvj54l	284	31	]	]	-RRB-
cord-005941-e4fvj54l	284	32	.	.	.
cord-005941-e4fvj54l	285	1	Diesel	diesel	NN
cord-005941-e4fvj54l	285	2	exhausts	exhaust	NNS
cord-005941-e4fvj54l	285	3	were	be	VBD
cord-005941-e4fvj54l	285	4	shown	show	VBN
cord-005941-e4fvj54l	285	5	to	to	TO
cord-005941-e4fvj54l	285	6	induce	induce	VB
cord-005941-e4fvj54l	285	7	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	285	8	phospholipidosis	phospholipidosis	NN
cord-005941-e4fvj54l	285	9	in	in	IN
cord-005941-e4fvj54l	285	10	rats	rat	NNS
cord-005941-e4fvj54l	285	11	[	[	-LRB-
cord-005941-e4fvj54l	285	12	37	37	CD
cord-005941-e4fvj54l	285	13	]	]	-RRB-
cord-005941-e4fvj54l	285	14	.	.	.
cord-005941-e4fvj54l	286	1	In	in	IN
cord-005941-e4fvj54l	286	2	another	another	DT
cord-005941-e4fvj54l	286	3	study	study	NN
cord-005941-e4fvj54l	286	4	,	,	,
cord-005941-e4fvj54l	286	5	short	short	JJ
cord-005941-e4fvj54l	286	6	-	-	HYPH
cord-005941-e4fvj54l	286	7	term	term	NN
cord-005941-e4fvj54l	286	8	exposure	exposure	NN
cord-005941-e4fvj54l	286	9	of	of	IN
cord-005941-e4fvj54l	286	10	rats	rat	NNS
cord-005941-e4fvj54l	286	11	to	to	IN
cord-005941-e4fvj54l	286	12	6	6	CD
cord-005941-e4fvj54l	286	13	mg	mg	NNP
cord-005941-e4fvj54l	286	14	/	/	SYM
cord-005941-e4fvj54l	286	15	m	m	NN
cord-005941-e4fvj54l	286	16	3	3	CD
cord-005941-e4fvj54l	286	17	diesel	diesel	NN
cord-005941-e4fvj54l	286	18	exhaust	exhaust	NN
cord-005941-e4fvj54l	286	19	resulted	result	VBD
cord-005941-e4fvj54l	286	20	in	in	IN
cord-005941-e4fvj54l	286	21	an	an	DT
cord-005941-e4fvj54l	286	22	increased	increase	VBN
cord-005941-e4fvj54l	286	23	labeling	labeling	NN
cord-005941-e4fvj54l	286	24	index	index	NN
cord-005941-e4fvj54l	286	25	in	in	IN
cord-005941-e4fvj54l	286	26	type	type	NN
cord-005941-e4fvj54l	286	27	II	ii	CD
cord-005941-e4fvj54l	286	28	cells	cell	NNS
cord-005941-e4fvj54l	286	29	and	and	CC
cord-005941-e4fvj54l	286	30	enhancement	enhancement	NN
cord-005941-e4fvj54l	286	31	of	of	IN
cord-005941-e4fvj54l	286	32	whole	whole	JJ
cord-005941-e4fvj54l	286	33	lung	lung	NN
cord-005941-e4fvj54l	286	34	D	D	NNP
cord-005941-e4fvj54l	286	35	N	N	NNP
cord-005941-e4fvj54l	286	36	A	a	DT
cord-005941-e4fvj54l	286	37	synthesis	synthesis	NN
cord-005941-e4fvj54l	286	38	[	[	-LRB-
cord-005941-e4fvj54l	286	39	195	195	CD
cord-005941-e4fvj54l	286	40	]	]	-RRB-
cord-005941-e4fvj54l	286	41	.	.	.
cord-005941-e4fvj54l	287	1	Additionally	additionally	RB
cord-005941-e4fvj54l	287	2	,	,	,
cord-005941-e4fvj54l	287	3	lavage	lavage	NN
cord-005941-e4fvj54l	287	4	phospholipid	phospholipid	NN
cord-005941-e4fvj54l	287	5	values	value	NNS
cord-005941-e4fvj54l	287	6	were	be	VBD
cord-005941-e4fvj54l	287	7	increased	increase	VBN
cord-005941-e4fvj54l	287	8	,	,	,
cord-005941-e4fvj54l	287	9	and	and	CC
cord-005941-e4fvj54l	287	10	there	there	EX
cord-005941-e4fvj54l	287	11	was	be	VBD
cord-005941-e4fvj54l	287	12	evidence	evidence	NN
cord-005941-e4fvj54l	287	13	of	of	IN
cord-005941-e4fvj54l	287	14	reversible	reversible	JJ
cord-005941-e4fvj54l	287	15	alterations	alteration	NNS
cord-005941-e4fvj54l	287	16	of	of	IN
cord-005941-e4fvj54l	287	17	fatty	fatty	JJ
cord-005941-e4fvj54l	287	18	acid	acid	NN
cord-005941-e4fvj54l	287	19	and	and	CC
cord-005941-e4fvj54l	287	20	phospholipid	phospholipid	NN
cord-005941-e4fvj54l	287	21	metabolism	metabolism	NN
cord-005941-e4fvj54l	287	22	.	.	.
cord-005941-e4fvj54l	288	1	Hydrogen	hydrogen	NN
cord-005941-e4fvj54l	288	2	sulfide	sulfide	NN
cord-005941-e4fvj54l	288	3	is	be	VBZ
cord-005941-e4fvj54l	288	4	an	an	DT
cord-005941-e4fvj54l	288	5	irritant	irritant	JJ
cord-005941-e4fvj54l	288	6	gas	gas	NN
cord-005941-e4fvj54l	288	7	with	with	IN
cord-005941-e4fvj54l	288	8	toxic	toxic	JJ
cord-005941-e4fvj54l	288	9	effects	effect	NNS
cord-005941-e4fvj54l	288	10	on	on	IN
cord-005941-e4fvj54l	288	11	the	the	DT
cord-005941-e4fvj54l	288	12	respiratory	respiratory	JJ
cord-005941-e4fvj54l	288	13	tract	tract	NN
cord-005941-e4fvj54l	288	14	.	.	.
cord-005941-e4fvj54l	289	1	An	an	DT
cord-005941-e4fvj54l	289	2	animal	animal	NN
cord-005941-e4fvj54l	289	3	study	study	NN
cord-005941-e4fvj54l	289	4	suggests	suggest	VBZ
cord-005941-e4fvj54l	289	5	that	that	IN
cord-005941-e4fvj54l	289	6	higher	high	JJR
cord-005941-e4fvj54l	289	7	doses	dose	NNS
cord-005941-e4fvj54l	289	8	impair	impair	VBP
cord-005941-e4fvj54l	289	9	the	the	DT
cord-005941-e4fvj54l	289	10	ability	ability	NN
cord-005941-e4fvj54l	289	11	of	of	IN
cord-005941-e4fvj54l	289	12	sur	sur	NN
cord-005941-e4fvj54l	289	13	-	-	HYPH
cord-005941-e4fvj54l	289	14	factant	factant	JJ
cord-005941-e4fvj54l	289	15	to	to	TO
cord-005941-e4fvj54l	289	16	lower	lower	VB
cord-005941-e4fvj54l	289	17	surface	surface	NN
cord-005941-e4fvj54l	289	18	tension	tension	NN
cord-005941-e4fvj54l	289	19	.	.	.
cord-005941-e4fvj54l	290	1	However	however	RB
cord-005941-e4fvj54l	290	2	,	,	,
cord-005941-e4fvj54l	290	3	this	this	DT
cord-005941-e4fvj54l	290	4	does	do	VBZ
cord-005941-e4fvj54l	290	5	not	not	RB
cord-005941-e4fvj54l	290	6	seem	seem	VB
cord-005941-e4fvj54l	290	7	to	to	TO
cord-005941-e4fvj54l	290	8	be	be	VB
cord-005941-e4fvj54l	290	9	due	due	JJ
cord-005941-e4fvj54l	290	10	to	to	IN
cord-005941-e4fvj54l	290	11	a	a	DT
cord-005941-e4fvj54l	290	12	direct	direct	JJ
cord-005941-e4fvj54l	290	13	effect	effect	NN
cord-005941-e4fvj54l	290	14	of	of	IN
cord-005941-e4fvj54l	290	15	hydrogen	hydrogen	NN
cord-005941-e4fvj54l	290	16	sulfide	sulfide	NN
cord-005941-e4fvj54l	290	17	on	on	IN
cord-005941-e4fvj54l	290	18	surfactant	surfactant	NN
cord-005941-e4fvj54l	290	19	material	material	NN
cord-005941-e4fvj54l	290	20	but	but	CC
cord-005941-e4fvj54l	290	21	due	due	IN
cord-005941-e4fvj54l	290	22	to	to	IN
cord-005941-e4fvj54l	290	23	surfactant	surfactant	NN
cord-005941-e4fvj54l	290	24	inhibitors	inhibitor	NNS
cord-005941-e4fvj54l	290	25	in	in	IN
cord-005941-e4fvj54l	290	26	the	the	DT
cord-005941-e4fvj54l	290	27	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	290	28	edema	edema	NN
cord-005941-e4fvj54l	290	29	fluid	fluid	NN
cord-005941-e4fvj54l	290	30	induced	induce	VBN
cord-005941-e4fvj54l	290	31	by	by	IN
cord-005941-e4fvj54l	290	32	hydrogen	hydrogen	NN
cord-005941-e4fvj54l	290	33	sulfide	sulfide	NN
cord-005941-e4fvj54l	290	34	[	[	-LRB-
cord-005941-e4fvj54l	290	35	53	53	CD
cord-005941-e4fvj54l	290	36	]	]	-RRB-
cord-005941-e4fvj54l	290	37	.	.	.
cord-005941-e4fvj54l	291	1	Dusts	dust	NNS
cord-005941-e4fvj54l	291	2	,	,	,
cord-005941-e4fvj54l	291	3	especially	especially	RB
cord-005941-e4fvj54l	291	4	those	those	DT
cord-005941-e4fvj54l	291	5	with	with	IN
cord-005941-e4fvj54l	291	6	a	a	DT
cord-005941-e4fvj54l	291	7	high	high	JJ
cord-005941-e4fvj54l	291	8	fibrogenic	fibrogenic	NN
cord-005941-e4fvj54l	291	9	potential	potential	NN
cord-005941-e4fvj54l	291	10	,	,	,
cord-005941-e4fvj54l	291	11	seem	seem	VBP
cord-005941-e4fvj54l	291	12	to	to	TO
cord-005941-e4fvj54l	291	13	stimulate	stimulate	VB
cord-005941-e4fvj54l	291	14	the	the	DT
cord-005941-e4fvj54l	291	15	production	production	NN
cord-005941-e4fvj54l	291	16	of	of	IN
cord-005941-e4fvj54l	291	17	surfactant	surfactant	NN
cord-005941-e4fvj54l	291	18	[	[	-LRB-
cord-005941-e4fvj54l	291	19	55	55	CD
cord-005941-e4fvj54l	291	20	]	]	-RRB-
cord-005941-e4fvj54l	291	21	.	.	.
cord-005941-e4fvj54l	292	1	Silica	silica	NN
cord-005941-e4fvj54l	292	2	(	(	-LRB-
cord-005941-e4fvj54l	292	3	usually	usually	RB
cord-005941-e4fvj54l	292	4	quartz	quartz	NN
cord-005941-e4fvj54l	292	5	dust	dust	NN
cord-005941-e4fvj54l	292	6	)	)	-RRB-
cord-005941-e4fvj54l	292	7	inhalation	inhalation	NN
cord-005941-e4fvj54l	292	8	leads	lead	VBZ
cord-005941-e4fvj54l	292	9	to	to	IN
cord-005941-e4fvj54l	292	10	a	a	DT
cord-005941-e4fvj54l	292	11	striking	striking	JJ
cord-005941-e4fvj54l	292	12	increase	increase	NN
cord-005941-e4fvj54l	292	13	in	in	IN
cord-005941-e4fvj54l	292	14	the	the	DT
cord-005941-e4fvj54l	292	15	alveolar	alveolar	NN
cord-005941-e4fvj54l	292	16	surfactant	surfactant	NN
cord-005941-e4fvj54l	292	17	phospholipid	phospholipid	NN
cord-005941-e4fvj54l	292	18	and	and	CC
cord-005941-e4fvj54l	292	19	SP	SP	NNP
cord-005941-e4fvj54l	292	20	-	-	HYPH
cord-005941-e4fvj54l	292	21	A	A	NNP
cord-005941-e4fvj54l	292	22	content	content	NN
cord-005941-e4fvj54l	292	23	[	[	-LRB-
cord-005941-e4fvj54l	292	24	31	31	CD
cord-005941-e4fvj54l	292	25	,	,	,
cord-005941-e4fvj54l	292	26	90	90	CD
cord-005941-e4fvj54l	292	27	]	]	-RRB-
cord-005941-e4fvj54l	292	28	.	.	.
cord-005941-e4fvj54l	293	1	Recently	recently	RB
cord-005941-e4fvj54l	293	2	,	,	,
cord-005941-e4fvj54l	293	3	the	the	DT
cord-005941-e4fvj54l	293	4	accumulation	accumulation	NN
cord-005941-e4fvj54l	293	5	of	of	IN
cord-005941-e4fvj54l	293	6	SP	SP	NNP
cord-005941-e4fvj54l	293	7	-	-	HYPH
cord-005941-e4fvj54l	293	8	D	D	NNP
cord-005941-e4fvj54l	293	9	has	have	VBZ
cord-005941-e4fvj54l	293	10	also	also	RB
cord-005941-e4fvj54l	293	11	been	be	VBN
cord-005941-e4fvj54l	293	12	reported	report	VBN
cord-005941-e4fvj54l	293	13	[	[	-LRB-
cord-005941-e4fvj54l	293	14	29	29	CD
cord-005941-e4fvj54l	293	15	]	]	-RRB-
cord-005941-e4fvj54l	293	16	.	.	.
cord-005941-e4fvj54l	294	1	Morphologically	Morphologically	NNP
cord-005941-e4fvj54l	294	2	,	,	,
cord-005941-e4fvj54l	294	3	these	these	DT
cord-005941-e4fvj54l	294	4	observations	observation	NNS
cord-005941-e4fvj54l	294	5	are	be	VBP
cord-005941-e4fvj54l	294	6	accompanied	accompany	VBN
cord-005941-e4fvj54l	294	7	by	by	IN
cord-005941-e4fvj54l	294	8	type	type	NN
cord-005941-e4fvj54l	294	9	II	ii	CD
cord-005941-e4fvj54l	294	10	cell	cell	NN
cord-005941-e4fvj54l	294	11	hypertrophy	hypertrophy	NN
cord-005941-e4fvj54l	294	12	and	and	CC
cord-005941-e4fvj54l	294	13	hyperplasia	hyperplasia	NN
cord-005941-e4fvj54l	294	14	[	[	-LRB-
cord-005941-e4fvj54l	294	15	90	90	CD
cord-005941-e4fvj54l	294	16	,	,	,
cord-005941-e4fvj54l	294	17	119	119	CD
cord-005941-e4fvj54l	294	18	]	]	-RRB-
cord-005941-e4fvj54l	294	19	.	.	.
cord-005941-e4fvj54l	295	1	The	the	DT
cord-005941-e4fvj54l	295	2	lungs	lung	NNS
cord-005941-e4fvj54l	295	3	of	of	IN
cord-005941-e4fvj54l	295	4	silica	silica	NN
cord-005941-e4fvj54l	295	5	-	-	HYPH
cord-005941-e4fvj54l	295	6	exposed	expose	VBN
cord-005941-e4fvj54l	295	7	animals	animal	NNS
cord-005941-e4fvj54l	295	8	share	share	VBP
cord-005941-e4fvj54l	295	9	common	common	JJ
cord-005941-e4fvj54l	295	10	features	feature	NNS
cord-005941-e4fvj54l	295	11	with	with	IN
cord-005941-e4fvj54l	295	12	alveolar	alveolar	NN
cord-005941-e4fvj54l	295	13	proteinosis	proteinosis	NN
cord-005941-e4fvj54l	295	14	in	in	IN
cord-005941-e4fvj54l	295	15	man	man	NN
cord-005941-e4fvj54l	295	16	so	so	IN
cord-005941-e4fvj54l	295	17	that	that	IN
cord-005941-e4fvj54l	295	18	they	-PRON-	PRP
cord-005941-e4fvj54l	295	19	may	may	MD
cord-005941-e4fvj54l	295	20	be	be	VB
cord-005941-e4fvj54l	295	21	used	use	VBN
cord-005941-e4fvj54l	295	22	as	as	IN
cord-005941-e4fvj54l	295	23	animal	animal	NN
cord-005941-e4fvj54l	295	24	models	model	NNS
cord-005941-e4fvj54l	295	25	of	of	IN
cord-005941-e4fvj54l	295	26	this	this	DT
cord-005941-e4fvj54l	295	27	disease	disease	NN
cord-005941-e4fvj54l	295	28	.	.	.
cord-005941-e4fvj54l	296	1	Asbestos	asbestos	NN
cord-005941-e4fvj54l	296	2	inhalation	inhalation	NN
cord-005941-e4fvj54l	296	3	provokes	provoke	VBZ
cord-005941-e4fvj54l	296	4	a	a	DT
cord-005941-e4fvj54l	296	5	very	very	RB
cord-005941-e4fvj54l	296	6	similar	similar	JJ
cord-005941-e4fvj54l	296	7	accumulation	accumulation	NN
cord-005941-e4fvj54l	296	8	of	of	IN
cord-005941-e4fvj54l	296	9	surfactant	surfactant	NN
cord-005941-e4fvj54l	296	10	material	material	NN
cord-005941-e4fvj54l	296	11	in	in	IN
cord-005941-e4fvj54l	296	12	the	the	DT
cord-005941-e4fvj54l	296	13	alveolar	alveolar	JJ
cord-005941-e4fvj54l	296	14	space	space	NN
cord-005941-e4fvj54l	296	15	[	[	-LRB-
cord-005941-e4fvj54l	296	16	38	38	CD
cord-005941-e4fvj54l	296	17	,	,	,
cord-005941-e4fvj54l	296	18	55	55	CD
cord-005941-e4fvj54l	296	19	]	]	-RRB-
cord-005941-e4fvj54l	296	20	.	.	.
cord-005941-e4fvj54l	297	1	The	the	DT
cord-005941-e4fvj54l	297	2	heavy	heavy	JJ
cord-005941-e4fvj54l	297	3	metal	metal	NN
cord-005941-e4fvj54l	297	4	cadmium	cadmium	NN
cord-005941-e4fvj54l	297	5	is	be	VBZ
cord-005941-e4fvj54l	297	6	a	a	DT
cord-005941-e4fvj54l	297	7	known	know	VBN
cord-005941-e4fvj54l	297	8	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	297	9	toxicant	toxicant	NN
cord-005941-e4fvj54l	297	10	.	.	.
cord-005941-e4fvj54l	298	1	The	the	DT
cord-005941-e4fvj54l	298	2	main	main	JJ
cord-005941-e4fvj54l	298	3	sources	source	NNS
cord-005941-e4fvj54l	298	4	of	of	IN
cord-005941-e4fvj54l	298	5	human	human	JJ
cord-005941-e4fvj54l	298	6	exposure	exposure	NN
cord-005941-e4fvj54l	298	7	are	be	VBP
cord-005941-e4fvj54l	298	8	cigarette	cigarette	NN
cord-005941-e4fvj54l	298	9	smoke	smoke	NN
cord-005941-e4fvj54l	298	10	,	,	,
cord-005941-e4fvj54l	298	11	automobile	automobile	NN
cord-005941-e4fvj54l	298	12	emissions	emission	NNS
cord-005941-e4fvj54l	298	13	,	,	,
cord-005941-e4fvj54l	298	14	and	and	CC
cord-005941-e4fvj54l	298	15	metal	metal	NN
cord-005941-e4fvj54l	298	16	-	-	HYPH
cord-005941-e4fvj54l	298	17	processing	process	VBG
cord-005941-e4fvj54l	298	18	plants	plant	NNS
cord-005941-e4fvj54l	298	19	.	.	.
cord-005941-e4fvj54l	299	1	In	in	IN
cord-005941-e4fvj54l	299	2	rats	rat	NNS
cord-005941-e4fvj54l	299	3	,	,	,
cord-005941-e4fvj54l	299	4	the	the	DT
cord-005941-e4fvj54l	299	5	inhalation	inhalation	NN
cord-005941-e4fvj54l	299	6	of	of	IN
cord-005941-e4fvj54l	299	7	cadmium	cadmium	NN
cord-005941-e4fvj54l	299	8	chloride	chloride	NN
cord-005941-e4fvj54l	299	9	led	lead	VBD
cord-005941-e4fvj54l	299	10	to	to	IN
cord-005941-e4fvj54l	299	11	an	an	DT
cord-005941-e4fvj54l	299	12	early	early	JJ
cord-005941-e4fvj54l	299	13	decrease	decrease	NN
cord-005941-e4fvj54l	299	14	of	of	IN
cord-005941-e4fvj54l	299	15	phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	299	16	in	in	IN
cord-005941-e4fvj54l	299	17	lung	lung	NN
cord-005941-e4fvj54l	299	18	lavage	lavage	NN
cord-005941-e4fvj54l	299	19	,	,	,
cord-005941-e4fvj54l	299	20	accompanied	accompany	VBN
cord-005941-e4fvj54l	299	21	by	by	IN
cord-005941-e4fvj54l	299	22	an	an	DT
cord-005941-e4fvj54l	299	23	increase	increase	NN
cord-005941-e4fvj54l	299	24	in	in	IN
cord-005941-e4fvj54l	299	25	tissue	tissue	NN
cord-005941-e4fvj54l	299	26	phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	299	27	.	.	.
cord-005941-e4fvj54l	300	1	After	after	IN
cord-005941-e4fvj54l	300	2	4	4	CD
cord-005941-e4fvj54l	300	3	days	day	NNS
cord-005941-e4fvj54l	300	4	,	,	,
cord-005941-e4fvj54l	300	5	levels	level	NNS
cord-005941-e4fvj54l	300	6	of	of	IN
cord-005941-e4fvj54l	300	7	lavage	lavage	NN
cord-005941-e4fvj54l	300	8	phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	300	9	then	then	RB
cord-005941-e4fvj54l	300	10	markedly	markedly	RB
cord-005941-e4fvj54l	300	11	increased	increase	VBD
cord-005941-e4fvj54l	300	12	above	above	IN
cord-005941-e4fvj54l	300	13	normal	normal	JJ
cord-005941-e4fvj54l	300	14	values	value	NNS
cord-005941-e4fvj54l	300	15	[	[	-LRB-
cord-005941-e4fvj54l	300	16	16	16	CD
cord-005941-e4fvj54l	300	17	]	]	-RRB-
cord-005941-e4fvj54l	300	18	.	.	.
cord-005941-e4fvj54l	301	1	In	in	IN
cord-005941-e4fvj54l	301	2	vitro	vitro	FW
cord-005941-e4fvj54l	301	3	studies	study	NNS
cord-005941-e4fvj54l	301	4	with	with	IN
cord-005941-e4fvj54l	301	5	alveolar	alveolar	NN
cord-005941-e4fvj54l	301	6	type	type	NN
cord-005941-e4fvj54l	301	7	II	ii	CD
cord-005941-e4fvj54l	301	8	cell	cell	NN
cord-005941-e4fvj54l	301	9	cultures	culture	NNS
cord-005941-e4fvj54l	301	10	exposed	expose	VBN
cord-005941-e4fvj54l	301	11	to	to	IN
cord-005941-e4fvj54l	301	12	cadmium	cadmium	NN
cord-005941-e4fvj54l	301	13	chloride	chloride	NN
cord-005941-e4fvj54l	301	14	demonstrated	demonstrate	VBD
cord-005941-e4fvj54l	301	15	inhibition	inhibition	NN
cord-005941-e4fvj54l	301	16	of	of	IN
cord-005941-e4fvj54l	301	17	surfactant	surfactant	NN
cord-005941-e4fvj54l	301	18	secretion	secretion	NN
cord-005941-e4fvj54l	301	19	,	,	,
cord-005941-e4fvj54l	301	20	while	while	IN
cord-005941-e4fvj54l	301	21	cadmium	cadmium	NN
cord-005941-e4fvj54l	301	22	alone	alone	RB
cord-005941-e4fvj54l	301	23	had	have	VBD
cord-005941-e4fvj54l	301	24	no	no	DT
cord-005941-e4fvj54l	301	25	such	such	JJ
cord-005941-e4fvj54l	301	26	effect	effect	NN
cord-005941-e4fvj54l	301	27	[	[	-LRB-
cord-005941-e4fvj54l	301	28	40	40	CD
cord-005941-e4fvj54l	301	29	]	]	-RRB-
cord-005941-e4fvj54l	301	30	.	.	.
cord-005941-e4fvj54l	302	1	Paraquat	Paraquat	NNP
cord-005941-e4fvj54l	302	2	,	,	,
cord-005941-e4fvj54l	302	3	a	a	DT
cord-005941-e4fvj54l	302	4	commercially	commercially	RB
cord-005941-e4fvj54l	302	5	important	important	JJ
cord-005941-e4fvj54l	302	6	herbicide	herbicide	NN
cord-005941-e4fvj54l	302	7	,	,	,
cord-005941-e4fvj54l	302	8	has	have	VBZ
cord-005941-e4fvj54l	302	9	marked	mark	VBN
cord-005941-e4fvj54l	302	10	toxic	toxic	JJ
cord-005941-e4fvj54l	302	11	effects	effect	NNS
cord-005941-e4fvj54l	302	12	on	on	IN
cord-005941-e4fvj54l	302	13	the	the	DT
cord-005941-e4fvj54l	302	14	lung	lung	NN
cord-005941-e4fvj54l	302	15	,	,	,
cord-005941-e4fvj54l	302	16	particularly	particularly	RB
cord-005941-e4fvj54l	302	17	on	on	IN
cord-005941-e4fvj54l	302	18	the	the	DT
cord-005941-e4fvj54l	302	19	alveolar	alveolar	JJ
cord-005941-e4fvj54l	302	20	type	type	NN
cord-005941-e4fvj54l	302	21	II	ii	CD
cord-005941-e4fvj54l	302	22	cell	cell	NN
cord-005941-e4fvj54l	302	23	.	.	.
cord-005941-e4fvj54l	303	1	In	in	IN
cord-005941-e4fvj54l	303	2	vivo	vivo	NN
cord-005941-e4fvj54l	303	3	and	and	CC
cord-005941-e4fvj54l	303	4	in	in	IN
cord-005941-e4fvj54l	303	5	vitro	vitro	FW
cord-005941-e4fvj54l	303	6	studies	study	NNS
cord-005941-e4fvj54l	303	7	have	have	VBP
cord-005941-e4fvj54l	303	8	shown	show	VBN
cord-005941-e4fvj54l	303	9	that	that	IN
cord-005941-e4fvj54l	303	10	the	the	DT
cord-005941-e4fvj54l	303	11	synthesis	synthesis	NN
cord-005941-e4fvj54l	303	12	of	of	IN
cord-005941-e4fvj54l	303	13	surfactant	surfactant	NN
cord-005941-e4fvj54l	303	14	phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	303	15	decreases	decrease	VBZ
cord-005941-e4fvj54l	303	16	after	after	IN
cord-005941-e4fvj54l	303	17	exposure	exposure	NN
cord-005941-e4fvj54l	303	18	.	.	.
cord-005941-e4fvj54l	304	1	However	however	RB
cord-005941-e4fvj54l	304	2	,	,	,
cord-005941-e4fvj54l	304	3	it	-PRON-	PRP
cord-005941-e4fvj54l	304	4	is	be	VBZ
cord-005941-e4fvj54l	304	5	not	not	RB
cord-005941-e4fvj54l	304	6	yet	yet	RB
cord-005941-e4fvj54l	304	7	clear	clear	JJ
cord-005941-e4fvj54l	304	8	whether	whether	IN
cord-005941-e4fvj54l	304	9	this	this	DT
cord-005941-e4fvj54l	304	10	effect	effect	NN
cord-005941-e4fvj54l	304	11	on	on	IN
cord-005941-e4fvj54l	304	12	surfactant	surfactant	NN
cord-005941-e4fvj54l	304	13	production	production	NN
cord-005941-e4fvj54l	304	14	is	be	VBZ
cord-005941-e4fvj54l	304	15	the	the	DT
cord-005941-e4fvj54l	304	16	primary	primary	JJ
cord-005941-e4fvj54l	304	17	cause	cause	NN
cord-005941-e4fvj54l	304	18	for	for	IN
cord-005941-e4fvj54l	304	19	paraquat	paraquat	NN
cord-005941-e4fvj54l	304	20	-	-	HYPH
cord-005941-e4fvj54l	304	21	associated	associate	VBN
cord-005941-e4fvj54l	304	22	respiratory	respiratory	JJ
cord-005941-e4fvj54l	304	23	failure	failure	NN
cord-005941-e4fvj54l	304	24	.	.	.
cord-005941-e4fvj54l	305	1	A	a	DT
cord-005941-e4fvj54l	305	2	major	major	JJ
cord-005941-e4fvj54l	305	3	problem	problem	NN
cord-005941-e4fvj54l	305	4	in	in	IN
cord-005941-e4fvj54l	305	5	the	the	DT
cord-005941-e4fvj54l	305	6	clinical	clinical	JJ
cord-005941-e4fvj54l	305	7	treatment	treatment	NN
cord-005941-e4fvj54l	305	8	of	of	IN
cord-005941-e4fvj54l	305	9	paraquat	paraquat	NN
cord-005941-e4fvj54l	305	10	poisoning	poisoning	NN
cord-005941-e4fvj54l	305	11	is	be	VBZ
cord-005941-e4fvj54l	305	12	the	the	DT
cord-005941-e4fvj54l	305	13	synergistic	synergistic	JJ
cord-005941-e4fvj54l	305	14	toxicity	toxicity	NN
cord-005941-e4fvj54l	305	15	of	of	IN
cord-005941-e4fvj54l	305	16	high	high	JJ
cord-005941-e4fvj54l	305	17	oxygen	oxygen	NN
cord-005941-e4fvj54l	305	18	mechanical	mechanical	JJ
cord-005941-e4fvj54l	305	19	ventilation	ventilation	NN
cord-005941-e4fvj54l	305	20	[	[	-LRB-
cord-005941-e4fvj54l	305	21	55	55	CD
cord-005941-e4fvj54l	305	22	]	]	-RRB-
cord-005941-e4fvj54l	305	23	.	.	.
cord-005941-e4fvj54l	306	1	The	the	DT
cord-005941-e4fvj54l	306	2	number	number	NN
cord-005941-e4fvj54l	306	3	of	of	IN
cord-005941-e4fvj54l	306	4	available	available	JJ
cord-005941-e4fvj54l	306	5	studies	study	NNS
cord-005941-e4fvj54l	306	6	on	on	IN
cord-005941-e4fvj54l	306	7	surfactant	surfactant	NN
cord-005941-e4fvj54l	306	8	changes	change	NNS
cord-005941-e4fvj54l	306	9	in	in	IN
cord-005941-e4fvj54l	306	10	human	human	JJ
cord-005941-e4fvj54l	306	11	lung	lung	NN
cord-005941-e4fvj54l	306	12	diseases	disease	NNS
cord-005941-e4fvj54l	306	13	is	be	VBZ
cord-005941-e4fvj54l	306	14	still	still	RB
cord-005941-e4fvj54l	306	15	limited	limited	JJ
cord-005941-e4fvj54l	306	16	.	.	.
cord-005941-e4fvj54l	307	1	However	however	RB
cord-005941-e4fvj54l	307	2	,	,	,
cord-005941-e4fvj54l	307	3	with	with	IN
cord-005941-e4fvj54l	307	4	further	further	JJ
cord-005941-e4fvj54l	307	5	improvement	improvement	NN
cord-005941-e4fvj54l	307	6	of	of	IN
cord-005941-e4fvj54l	307	7	investigative	investigative	JJ
cord-005941-e4fvj54l	307	8	tools	tool	NNS
cord-005941-e4fvj54l	307	9	and	and	CC
cord-005941-e4fvj54l	307	10	increasing	increase	VBG
cord-005941-e4fvj54l	307	11	interest	interest	NN
cord-005941-e4fvj54l	307	12	in	in	IN
cord-005941-e4fvj54l	307	13	possible	possible	JJ
cord-005941-e4fvj54l	307	14	clinical	clinical	JJ
cord-005941-e4fvj54l	307	15	implications	implication	NNS
cord-005941-e4fvj54l	307	16	,	,	,
cord-005941-e4fvj54l	307	17	it	-PRON-	PRP
cord-005941-e4fvj54l	307	18	should	should	MD
cord-005941-e4fvj54l	307	19	be	be	VB
cord-005941-e4fvj54l	307	20	expected	expect	VBN
cord-005941-e4fvj54l	307	21	that	that	IN
cord-005941-e4fvj54l	307	22	such	such	JJ
cord-005941-e4fvj54l	307	23	studies	study	NNS
cord-005941-e4fvj54l	307	24	will	will	MD
cord-005941-e4fvj54l	307	25	prosper	prosper	VB
cord-005941-e4fvj54l	307	26	in	in	IN
cord-005941-e4fvj54l	307	27	the	the	DT
cord-005941-e4fvj54l	307	28	near	near	JJ
cord-005941-e4fvj54l	307	29	future	future	NN
cord-005941-e4fvj54l	307	30	.	.	.
cord-005941-e4fvj54l	308	1	The	the	DT
cord-005941-e4fvj54l	308	2	main	main	JJ
cord-005941-e4fvj54l	308	3	material	material	NN
cord-005941-e4fvj54l	308	4	for	for	IN
cord-005941-e4fvj54l	308	5	surfactant	surfactant	NN
cord-005941-e4fvj54l	308	6	studies	study	NNS
cord-005941-e4fvj54l	308	7	in	in	IN
cord-005941-e4fvj54l	308	8	man	man	NN
cord-005941-e4fvj54l	308	9	is	be	VBZ
cord-005941-e4fvj54l	308	10	BAL	bal	NN
cord-005941-e4fvj54l	308	11	because	because	IN
cord-005941-e4fvj54l	308	12	it	-PRON-	PRP
cord-005941-e4fvj54l	308	13	is	be	VBZ
cord-005941-e4fvj54l	308	14	available	available	JJ
cord-005941-e4fvj54l	308	15	at	at	IN
cord-005941-e4fvj54l	308	16	a	a	DT
cord-005941-e4fvj54l	308	17	low	low	JJ
cord-005941-e4fvj54l	308	18	risk	risk	NN
cord-005941-e4fvj54l	308	19	to	to	IN
cord-005941-e4fvj54l	308	20	the	the	DT
cord-005941-e4fvj54l	308	21	patient	patient	NN
cord-005941-e4fvj54l	308	22	and	and	CC
cord-005941-e4fvj54l	308	23	gives	give	VBZ
cord-005941-e4fvj54l	308	24	access	access	NN
cord-005941-e4fvj54l	308	25	to	to	IN
cord-005941-e4fvj54l	308	26	all	all	DT
cord-005941-e4fvj54l	308	27	alveolar	alveolar	JJ
cord-005941-e4fvj54l	308	28	surfactant	surfactant	NN
cord-005941-e4fvj54l	308	29	components	component	NNS
cord-005941-e4fvj54l	308	30	.	.	.
cord-005941-e4fvj54l	309	1	Nev-647	Nev-647	NNP
cord-005941-e4fvj54l	309	2	ertheless	ertheless	NN
cord-005941-e4fvj54l	309	3	,	,	,
cord-005941-e4fvj54l	309	4	this	this	DT
cord-005941-e4fvj54l	309	5	method	method	NN
cord-005941-e4fvj54l	309	6	has	have	VBZ
cord-005941-e4fvj54l	309	7	its	-PRON-	PRP$
cord-005941-e4fvj54l	309	8	limitations	limitation	NNS
cord-005941-e4fvj54l	309	9	.	.	.
cord-005941-e4fvj54l	310	1	BAL	BAL	NNP
cord-005941-e4fvj54l	310	2	does	do	VBZ
cord-005941-e4fvj54l	310	3	not	not	RB
cord-005941-e4fvj54l	310	4	give	give	VB
cord-005941-e4fvj54l	310	5	direct	direct	JJ
cord-005941-e4fvj54l	310	6	insight	insight	NN
cord-005941-e4fvj54l	310	7	into	into	IN
cord-005941-e4fvj54l	310	8	cellular	cellular	JJ
cord-005941-e4fvj54l	310	9	changes	change	NNS
cord-005941-e4fvj54l	310	10	of	of	IN
cord-005941-e4fvj54l	310	11	alveolar	alveolar	JJ
cord-005941-e4fvj54l	310	12	type	type	NN
cord-005941-e4fvj54l	310	13	II	ii	CD
cord-005941-e4fvj54l	310	14	cells	cell	NNS
cord-005941-e4fvj54l	310	15	and	and	CC
cord-005941-e4fvj54l	310	16	methods	method	NNS
cord-005941-e4fvj54l	310	17	of	of	IN
cord-005941-e4fvj54l	310	18	quantification	quantification	NN
cord-005941-e4fvj54l	310	19	of	of	IN
cord-005941-e4fvj54l	310	20	the	the	DT
cord-005941-e4fvj54l	310	21	obtained	obtain	VBN
cord-005941-e4fvj54l	310	22	epithelial	epithelial	JJ
cord-005941-e4fvj54l	310	23	lining	lining	NN
cord-005941-e4fvj54l	310	24	fluid	fluid	NN
cord-005941-e4fvj54l	310	25	are	be	VBP
cord-005941-e4fvj54l	310	26	limited	limit	VBN
cord-005941-e4fvj54l	310	27	by	by	IN
cord-005941-e4fvj54l	310	28	the	the	DT
cord-005941-e4fvj54l	310	29	complex	complex	JJ
cord-005941-e4fvj54l	310	30	nature	nature	NN
cord-005941-e4fvj54l	310	31	of	of	IN
cord-005941-e4fvj54l	310	32	fluid	fluid	JJ
cord-005941-e4fvj54l	310	33	dynamics	dynamic	NNS
cord-005941-e4fvj54l	310	34	during	during	IN
cord-005941-e4fvj54l	310	35	the	the	DT
cord-005941-e4fvj54l	310	36	procedure	procedure	NN
cord-005941-e4fvj54l	310	37	[	[	-LRB-
cord-005941-e4fvj54l	310	38	92	92	CD
cord-005941-e4fvj54l	310	39	,	,	,
cord-005941-e4fvj54l	310	40	111	111	CD
cord-005941-e4fvj54l	310	41	]	]	-RRB-
cord-005941-e4fvj54l	310	42	.	.	.
cord-005941-e4fvj54l	311	1	Also	also	RB
cord-005941-e4fvj54l	311	2	,	,	,
cord-005941-e4fvj54l	311	3	not	not	RB
cord-005941-e4fvj54l	311	4	all	all	DT
cord-005941-e4fvj54l	311	5	phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	311	6	in	in	IN
cord-005941-e4fvj54l	311	7	BAL	BAL	NNP
cord-005941-e4fvj54l	311	8	fluid	fluid	NN
cord-005941-e4fvj54l	311	9	must	must	MD
cord-005941-e4fvj54l	311	10	necessarily	necessarily	RB
cord-005941-e4fvj54l	311	11	be	be	VB
cord-005941-e4fvj54l	311	12	surfactant	surfactant	NN
cord-005941-e4fvj54l	311	13	phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	311	14	.	.	.
cord-005941-e4fvj54l	312	1	They	-PRON-	PRP
cord-005941-e4fvj54l	312	2	may	may	MD
cord-005941-e4fvj54l	312	3	in	in	IN
cord-005941-e4fvj54l	312	4	part	part	NN
cord-005941-e4fvj54l	312	5	stem	stem	NN
cord-005941-e4fvj54l	312	6	from	from	IN
cord-005941-e4fvj54l	312	7	airway	airway	JJ
cord-005941-e4fvj54l	312	8	epithelial	epithelial	JJ
cord-005941-e4fvj54l	312	9	cell	cell	NN
cord-005941-e4fvj54l	312	10	secretions	secretion	NNS
cord-005941-e4fvj54l	312	11	[	[	-LRB-
cord-005941-e4fvj54l	312	12	93	93	CD
cord-005941-e4fvj54l	312	13	]	]	-RRB-
cord-005941-e4fvj54l	312	14	or	or	CC
cord-005941-e4fvj54l	312	15	from	from	IN
cord-005941-e4fvj54l	312	16	cell	cell	NN
cord-005941-e4fvj54l	312	17	membranes	membrane	NNS
cord-005941-e4fvj54l	312	18	(	(	-LRB-
cord-005941-e4fvj54l	312	19	alveolar	alveolar	NN
cord-005941-e4fvj54l	312	20	cells	cell	NNS
cord-005941-e4fvj54l	312	21	,	,	,
cord-005941-e4fvj54l	312	22	but	but	CC
cord-005941-e4fvj54l	312	23	also	also	RB
cord-005941-e4fvj54l	312	24	leucocytes	leucocytes	NNP
cord-005941-e4fvj54l	312	25	,	,	,
cord-005941-e4fvj54l	312	26	macrophages	macrophage	NNS
cord-005941-e4fvj54l	312	27	,	,	,
cord-005941-e4fvj54l	312	28	etc	etc	FW
cord-005941-e4fvj54l	312	29	.	.	.
cord-005941-e4fvj54l	312	30	)	)	-RRB-
cord-005941-e4fvj54l	312	31	,	,	,
cord-005941-e4fvj54l	312	32	which	which	WDT
cord-005941-e4fvj54l	312	33	seems	seem	VBZ
cord-005941-e4fvj54l	312	34	particularly	particularly	RB
cord-005941-e4fvj54l	312	35	important	important	JJ
cord-005941-e4fvj54l	312	36	to	to	TO
cord-005941-e4fvj54l	312	37	consider	consider	VB
cord-005941-e4fvj54l	312	38	in	in	IN
cord-005941-e4fvj54l	312	39	inflammatory	inflammatory	JJ
cord-005941-e4fvj54l	312	40	lung	lung	NN
cord-005941-e4fvj54l	312	41	diseases	disease	NNS
cord-005941-e4fvj54l	312	42	(	(	-LRB-
cord-005941-e4fvj54l	312	43	e.g.	e.g.	RB
cord-005941-e4fvj54l	312	44	,	,	,
cord-005941-e4fvj54l	312	45	[	[	-LRB-
cord-005941-e4fvj54l	312	46	148	148	CD
cord-005941-e4fvj54l	312	47	]	]	-RRB-
cord-005941-e4fvj54l	312	48	)	)	-RRB-
cord-005941-e4fvj54l	312	49	.	.	.
cord-005941-e4fvj54l	313	1	Nonetheless	nonetheless	RB
cord-005941-e4fvj54l	313	2	,	,	,
cord-005941-e4fvj54l	313	3	the	the	DT
cord-005941-e4fvj54l	313	4	first	first	JJ
cord-005941-e4fvj54l	313	5	clinical	clinical	JJ
cord-005941-e4fvj54l	313	6	studies	study	NNS
cord-005941-e4fvj54l	313	7	have	have	VBP
cord-005941-e4fvj54l	313	8	shown	show	VBN
cord-005941-e4fvj54l	313	9	that	that	IN
cord-005941-e4fvj54l	313	10	quantitative	quantitative	JJ
cord-005941-e4fvj54l	313	11	changes	change	NNS
cord-005941-e4fvj54l	313	12	of	of	IN
cord-005941-e4fvj54l	313	13	surfactant	surfactant	NN
cord-005941-e4fvj54l	313	14	components	component	NNS
cord-005941-e4fvj54l	313	15	in	in	IN
cord-005941-e4fvj54l	313	16	different	different	JJ
cord-005941-e4fvj54l	313	17	lung	lung	NN
cord-005941-e4fvj54l	313	18	diseases	disease	NNS
cord-005941-e4fvj54l	313	19	can	can	MD
cord-005941-e4fvj54l	313	20	be	be	VB
cord-005941-e4fvj54l	313	21	found	find	VBN
cord-005941-e4fvj54l	313	22	in	in	IN
cord-005941-e4fvj54l	313	23	comparison	comparison	NN
cord-005941-e4fvj54l	313	24	with	with	IN
cord-005941-e4fvj54l	313	25	healthy	healthy	JJ
cord-005941-e4fvj54l	313	26	controls	control	NNS
cord-005941-e4fvj54l	313	27	.	.	.
cord-005941-e4fvj54l	314	1	Normal	normal	JJ
cord-005941-e4fvj54l	314	2	values	value	NNS
cord-005941-e4fvj54l	314	3	for	for	IN
cord-005941-e4fvj54l	314	4	SP	SP	NNP
cord-005941-e4fvj54l	314	5	-	-	HYPH
cord-005941-e4fvj54l	314	6	A	A	NNP
cord-005941-e4fvj54l	314	7	in	in	IN
cord-005941-e4fvj54l	314	8	human	human	JJ
cord-005941-e4fvj54l	314	9	BAL	bal	NN
cord-005941-e4fvj54l	314	10	are	be	VBP
cord-005941-e4fvj54l	314	11	found	find	VBN
cord-005941-e4fvj54l	314	12	in	in	IN
cord-005941-e4fvj54l	314	13	the	the	DT
cord-005941-e4fvj54l	314	14	range	range	NN
cord-005941-e4fvj54l	314	15	of	of	IN
cord-005941-e4fvj54l	314	16	about	about	RB
cord-005941-e4fvj54l	314	17	0.5	0.5	CD
cord-005941-e4fvj54l	314	18	-	-	SYM
cord-005941-e4fvj54l	314	19	3	3	CD
cord-005941-e4fvj54l	314	20	~tg	~tg	NNS
cord-005941-e4fvj54l	314	21	/	/	SYM
cord-005941-e4fvj54l	314	22	ml	ml	IN
cord-005941-e4fvj54l	314	23	lavage	lavage	NN
cord-005941-e4fvj54l	314	24	fluid	fluid	NN
cord-005941-e4fvj54l	314	25	(	(	-LRB-
cord-005941-e4fvj54l	314	26	[	[	-LRB-
cord-005941-e4fvj54l	314	27	62	62	CD
cord-005941-e4fvj54l	314	28	,	,	,
cord-005941-e4fvj54l	314	29	116	116	CD
cord-005941-e4fvj54l	314	30	,	,	,
cord-005941-e4fvj54l	314	31	142	142	CD
cord-005941-e4fvj54l	314	32	]	]	-RRB-
cord-005941-e4fvj54l	314	33	and	and	CC
cord-005941-e4fvj54l	314	34	own	own	JJ
cord-005941-e4fvj54l	314	35	unpublished	unpublished	JJ
cord-005941-e4fvj54l	314	36	data	datum	NNS
cord-005941-e4fvj54l	314	37	)	)	-RRB-
cord-005941-e4fvj54l	314	38	.	.	.
cord-005941-e4fvj54l	315	1	Normal	normal	JJ
cord-005941-e4fvj54l	315	2	total	total	JJ
cord-005941-e4fvj54l	315	3	phospholipid	phospholipid	NN
cord-005941-e4fvj54l	315	4	levels	level	NNS
cord-005941-e4fvj54l	315	5	seem	seem	VBP
cord-005941-e4fvj54l	315	6	to	to	TO
cord-005941-e4fvj54l	315	7	vary	vary	VB
cord-005941-e4fvj54l	315	8	considerably	considerably	RB
cord-005941-e4fvj54l	315	9	among	among	IN
cord-005941-e4fvj54l	315	10	individuals	individual	NNS
cord-005941-e4fvj54l	315	11	and	and	CC
cord-005941-e4fvj54l	315	12	also	also	RB
cord-005941-e4fvj54l	315	13	among	among	IN
cord-005941-e4fvj54l	315	14	laboratories	laboratory	NNS
cord-005941-e4fvj54l	315	15	[	[	-LRB-
cord-005941-e4fvj54l	315	16	61	61	CD
cord-005941-e4fvj54l	315	17	,	,	,
cord-005941-e4fvj54l	315	18	76	76	CD
cord-005941-e4fvj54l	315	19	,	,	,
cord-005941-e4fvj54l	315	20	77	77	CD
cord-005941-e4fvj54l	315	21	,	,	,
cord-005941-e4fvj54l	315	22	81	81	CD
cord-005941-e4fvj54l	315	23	,	,	,
cord-005941-e4fvj54l	315	24	116	116	CD
cord-005941-e4fvj54l	315	25	,	,	,
cord-005941-e4fvj54l	315	26	143	143	CD
cord-005941-e4fvj54l	315	27	,	,	,
cord-005941-e4fvj54l	315	28	154	154	CD
cord-005941-e4fvj54l	315	29	]	]	-RRB-
cord-005941-e4fvj54l	315	30	.	.	.
cord-005941-e4fvj54l	316	1	Additionally	additionally	RB
cord-005941-e4fvj54l	316	2	,	,	,
cord-005941-e4fvj54l	316	3	chromatographic	chromatographic	JJ
cord-005941-e4fvj54l	316	4	determination	determination	NN
cord-005941-e4fvj54l	316	5	of	of	IN
cord-005941-e4fvj54l	316	6	the	the	DT
cord-005941-e4fvj54l	316	7	distribution	distribution	NN
cord-005941-e4fvj54l	316	8	of	of	IN
cord-005941-e4fvj54l	316	9	individual	individual	JJ
cord-005941-e4fvj54l	316	10	BAL	bal	NN
cord-005941-e4fvj54l	316	11	phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	316	12	(	(	-LRB-
cord-005941-e4fvj54l	316	13	Fig	Fig	NNP
cord-005941-e4fvj54l	316	14	.	.	.
cord-005941-e4fvj54l	316	15	1	1	CD
cord-005941-e4fvj54l	316	16	)	)	-RRB-
cord-005941-e4fvj54l	316	17	is	be	VBZ
cord-005941-e4fvj54l	316	18	often	often	RB
cord-005941-e4fvj54l	316	19	used	use	VBN
cord-005941-e4fvj54l	316	20	to	to	TO
cord-005941-e4fvj54l	316	21	describe	describe	VB
cord-005941-e4fvj54l	316	22	surfactant	surfactant	NN
cord-005941-e4fvj54l	316	23	abnormalities	abnormality	NNS
cord-005941-e4fvj54l	316	24	.	.	.
cord-005941-e4fvj54l	317	1	Recently	recently	RB
cord-005941-e4fvj54l	317	2	,	,	,
cord-005941-e4fvj54l	317	3	simpler	simple	JJR
cord-005941-e4fvj54l	317	4	enzymatic	enzymatic	JJ
cord-005941-e4fvj54l	317	5	methods	method	NNS
cord-005941-e4fvj54l	317	6	were	be	VBD
cord-005941-e4fvj54l	317	7	recommended	recommend	VBN
cord-005941-e4fvj54l	317	8	for	for	IN
cord-005941-e4fvj54l	317	9	phospholipid	phospholipid	NN
cord-005941-e4fvj54l	317	10	analysis	analysis	NN
cord-005941-e4fvj54l	317	11	in	in	IN
cord-005941-e4fvj54l	317	12	BAL	bal	NN
cord-005941-e4fvj54l	317	13	fluids	fluid	NNS
cord-005941-e4fvj54l	317	14	[	[	-LRB-
cord-005941-e4fvj54l	317	15	48	48	CD
cord-005941-e4fvj54l	317	16	]	]	-RRB-
cord-005941-e4fvj54l	317	17	.	.	.
cord-005941-e4fvj54l	318	1	However	however	RB
cord-005941-e4fvj54l	318	2	,	,	,
cord-005941-e4fvj54l	318	3	at	at	IN
cord-005941-e4fvj54l	318	4	present	present	JJ
cord-005941-e4fvj54l	318	5	,	,	,
cord-005941-e4fvj54l	318	6	only	only	RB
cord-005941-e4fvj54l	318	7	phosphatidylcholine	phosphatidylcholine	NN
cord-005941-e4fvj54l	318	8	and	and	CC
cord-005941-e4fvj54l	318	9	phosphatidylglycerol	phosphatidylglycerol	NNP
cord-005941-e4fvj54l	318	10	may	may	MD
cord-005941-e4fvj54l	318	11	be	be	VB
cord-005941-e4fvj54l	318	12	quantified	quantify	VBN
cord-005941-e4fvj54l	318	13	by	by	IN
cord-005941-e4fvj54l	318	14	this	this	DT
cord-005941-e4fvj54l	318	15	method	method	NN
cord-005941-e4fvj54l	318	16	.	.	.
cord-005941-e4fvj54l	319	1	Another	another	DT
cord-005941-e4fvj54l	319	2	frequent	frequent	JJ
cord-005941-e4fvj54l	319	3	approach	approach	NN
cord-005941-e4fvj54l	319	4	is	be	VBZ
cord-005941-e4fvj54l	319	5	to	to	TO
cord-005941-e4fvj54l	319	6	investigate	investigate	VB
cord-005941-e4fvj54l	319	7	the	the	DT
cord-005941-e4fvj54l	319	8	biophysical	biophysical	JJ
cord-005941-e4fvj54l	319	9	properties	property	NNS
cord-005941-e4fvj54l	319	10	(	(	-LRB-
cord-005941-e4fvj54l	319	11	ability	ability	NN
cord-005941-e4fvj54l	319	12	to	to	TO
cord-005941-e4fvj54l	319	13	lower	lower	VB
cord-005941-e4fvj54l	319	14	surface	surface	NN
cord-005941-e4fvj54l	319	15	tension	tension	NN
cord-005941-e4fvj54l	319	16	)	)	-RRB-
cord-005941-e4fvj54l	319	17	of	of	IN
cord-005941-e4fvj54l	319	18	the	the	DT
cord-005941-e4fvj54l	319	19	obtained	obtain	VBN
cord-005941-e4fvj54l	319	20	surfactant	surfactant	NN
cord-005941-e4fvj54l	319	21	material	material	NN
cord-005941-e4fvj54l	319	22	.	.	.
cord-005941-e4fvj54l	320	1	Various	various	JJ
cord-005941-e4fvj54l	320	2	conditions	condition	NNS
cord-005941-e4fvj54l	320	3	such	such	JJ
cord-005941-e4fvj54l	320	4	as	as	IN
cord-005941-e4fvj54l	320	5	severe	severe	JJ
cord-005941-e4fvj54l	320	6	trauma	trauma	NN
cord-005941-e4fvj54l	320	7	,	,	,
cord-005941-e4fvj54l	320	8	major	major	JJ
cord-005941-e4fvj54l	320	9	surgical	surgical	JJ
cord-005941-e4fvj54l	320	10	procedures	procedure	NNS
cord-005941-e4fvj54l	320	11	,	,	,
cord-005941-e4fvj54l	320	12	burns	burn	NNS
cord-005941-e4fvj54l	320	13	,	,	,
cord-005941-e4fvj54l	320	14	sepsis	sepsis	NN
cord-005941-e4fvj54l	320	15	,	,	,
cord-005941-e4fvj54l	320	16	acute	acute	JJ
cord-005941-e4fvj54l	320	17	pancreatitis	pancreatitis	NN
cord-005941-e4fvj54l	320	18	,	,	,
cord-005941-e4fvj54l	320	19	and	and	CC
cord-005941-e4fvj54l	320	20	aspiration	aspiration	NN
cord-005941-e4fvj54l	320	21	pneumonia	pneumonia	NN
cord-005941-e4fvj54l	320	22	are	be	VBP
cord-005941-e4fvj54l	320	23	capable	capable	JJ
cord-005941-e4fvj54l	320	24	of	of	IN
cord-005941-e4fvj54l	320	25	inducing	induce	VBG
cord-005941-e4fvj54l	320	26	this	this	DT
cord-005941-e4fvj54l	320	27	form	form	NN
cord-005941-e4fvj54l	320	28	of	of	IN
cord-005941-e4fvj54l	320	29	acute	acute	JJ
cord-005941-e4fvj54l	320	30	lung	lung	NN
cord-005941-e4fvj54l	320	31	injury	injury	NN
cord-005941-e4fvj54l	320	32	.	.	.
cord-005941-e4fvj54l	321	1	It	-PRON-	PRP
cord-005941-e4fvj54l	321	2	may	may	MD
cord-005941-e4fvj54l	321	3	rapidly	rapidly	RB
cord-005941-e4fvj54l	321	4	progress	progress	VB
cord-005941-e4fvj54l	321	5	to	to	IN
cord-005941-e4fvj54l	321	6	respiratory	respiratory	JJ
cord-005941-e4fvj54l	321	7	failure	failure	NN
cord-005941-e4fvj54l	321	8	and	and	CC
cord-005941-e4fvj54l	321	9	continues	continue	VBZ
cord-005941-e4fvj54l	321	10	to	to	TO
cord-005941-e4fvj54l	321	11	have	have	VB
cord-005941-e4fvj54l	321	12	a	a	DT
cord-005941-e4fvj54l	321	13	high	high	JJ
cord-005941-e4fvj54l	321	14	mortality	mortality	NN
cord-005941-e4fvj54l	321	15	of	of	IN
cord-005941-e4fvj54l	321	16	around	around	IN
cord-005941-e4fvj54l	321	17	50%-65	50%-65	CD
cord-005941-e4fvj54l	321	18	%	%	NN
cord-005941-e4fvj54l	321	19	[	[	-LRB-
cord-005941-e4fvj54l	321	20	36	36	CD
cord-005941-e4fvj54l	321	21	,	,	,
cord-005941-e4fvj54l	321	22	45	45	CD
cord-005941-e4fvj54l	321	23	]	]	-RRB-
cord-005941-e4fvj54l	321	24	with	with	IN
cord-005941-e4fvj54l	321	25	hardly	hardly	RB
cord-005941-e4fvj54l	321	26	a	a	DT
cord-005941-e4fvj54l	321	27	change	change	NN
cord-005941-e4fvj54l	321	28	over	over	IN
cord-005941-e4fvj54l	321	29	the	the	DT
cord-005941-e4fvj54l	321	30	years	year	NNS
cord-005941-e4fvj54l	321	31	in	in	IN
cord-005941-e4fvj54l	321	32	spite	spite	NN
cord-005941-e4fvj54l	321	33	of	of	IN
cord-005941-e4fvj54l	321	34	many	many	JJ
cord-005941-e4fvj54l	321	35	improvements	improvement	NNS
cord-005941-e4fvj54l	321	36	in	in	IN
cord-005941-e4fvj54l	321	37	modern	modern	JJ
cord-005941-e4fvj54l	321	38	intensive	intensive	JJ
cord-005941-e4fvj54l	321	39	care	care	NN
cord-005941-e4fvj54l	321	40	medicine	medicine	NN
cord-005941-e4fvj54l	321	41	.	.	.
cord-005941-e4fvj54l	322	1	ARDS	ARDS	NNP
cord-005941-e4fvj54l	322	2	may	may	MD
cord-005941-e4fvj54l	322	3	be	be	VB
cord-005941-e4fvj54l	322	4	triggered	trigger	VBN
cord-005941-e4fvj54l	322	5	or	or	CC
cord-005941-e4fvj54l	322	6	aggravated	aggravate	VBN
cord-005941-e4fvj54l	322	7	by	by	IN
cord-005941-e4fvj54l	322	8	high	high	JJ
cord-005941-e4fvj54l	322	9	oxygen	oxygen	NN
cord-005941-e4fvj54l	322	10	mechanical	mechanical	JJ
cord-005941-e4fvj54l	322	11	ventilation	ventilation	NN
cord-005941-e4fvj54l	322	12	which	which	WDT
cord-005941-e4fvj54l	322	13	is	be	VBZ
cord-005941-e4fvj54l	322	14	necessary	necessary	JJ
cord-005941-e4fvj54l	322	15	in	in	IN
cord-005941-e4fvj54l	322	16	many	many	JJ
cord-005941-e4fvj54l	322	17	of	of	IN
cord-005941-e4fvj54l	322	18	these	these	DT
cord-005941-e4fvj54l	322	19	patients	patient	NNS
cord-005941-e4fvj54l	322	20	.	.	.
cord-005941-e4fvj54l	323	1	Surfactant	surfactant	NN
cord-005941-e4fvj54l	323	2	changes	change	NNS
cord-005941-e4fvj54l	323	3	are	be	VBP
cord-005941-e4fvj54l	323	4	thought	think	VBN
cord-005941-e4fvj54l	323	5	to	to	TO
cord-005941-e4fvj54l	323	6	play	play	VB
cord-005941-e4fvj54l	323	7	an	an	DT
cord-005941-e4fvj54l	323	8	important	important	JJ
cord-005941-e4fvj54l	323	9	role	role	NN
cord-005941-e4fvj54l	323	10	in	in	IN
cord-005941-e4fvj54l	323	11	the	the	DT
cord-005941-e4fvj54l	323	12	pathogenesis	pathogenesis	NN
cord-005941-e4fvj54l	323	13	of	of	IN
cord-005941-e4fvj54l	323	14	this	this	DT
cord-005941-e4fvj54l	323	15	condition	condition	NN
cord-005941-e4fvj54l	323	16	.	.	.
cord-005941-e4fvj54l	324	1	However	however	RB
cord-005941-e4fvj54l	324	2	,	,	,
cord-005941-e4fvj54l	324	3	it	-PRON-	PRP
cord-005941-e4fvj54l	324	4	should	should	MD
cord-005941-e4fvj54l	324	5	be	be	VB
cord-005941-e4fvj54l	324	6	emphasized	emphasize	VBN
cord-005941-e4fvj54l	324	7	that	that	IN
cord-005941-e4fvj54l	324	8	ARDS	ARDS	NNP
cord-005941-e4fvj54l	324	9	is	be	VBZ
cord-005941-e4fvj54l	324	10	a	a	DT
cord-005941-e4fvj54l	324	11	severe	severe	JJ
cord-005941-e4fvj54l	324	12	,	,	,
cord-005941-e4fvj54l	324	13	multifactorial	multifactorial	JJ
cord-005941-e4fvj54l	324	14	disease	disease	NN
cord-005941-e4fvj54l	324	15	in	in	IN
cord-005941-e4fvj54l	324	16	which	which	WDT
cord-005941-e4fvj54l	324	17	surfactant	surfactant	NN
cord-005941-e4fvj54l	324	18	is	be	VBZ
cord-005941-e4fvj54l	324	19	only	only	RB
cord-005941-e4fvj54l	324	20	one	one	CD
cord-005941-e4fvj54l	324	21	piece	piece	NN
cord-005941-e4fvj54l	324	22	of	of	IN
cord-005941-e4fvj54l	324	23	the	the	DT
cord-005941-e4fvj54l	324	24	puzzle	puzzle	NN
cord-005941-e4fvj54l	324	25	.	.	.
cord-005941-e4fvj54l	325	1	Serious	serious	JJ
cord-005941-e4fvj54l	325	2	disturbances	disturbance	NNS
cord-005941-e4fvj54l	325	3	of	of	IN
cord-005941-e4fvj54l	325	4	surfactant	surfactant	NN
cord-005941-e4fvj54l	325	5	phospholipid	phospholipid	NN
cord-005941-e4fvj54l	325	6	composition	composition	NN
cord-005941-e4fvj54l	325	7	and	and	CC
cord-005941-e4fvj54l	325	8	surfactant	surfactant	NN
cord-005941-e4fvj54l	325	9	function	function	NN
cord-005941-e4fvj54l	325	10	as	as	RB
cord-005941-e4fvj54l	325	11	well	well	RB
cord-005941-e4fvj54l	325	12	as	as	IN
cord-005941-e4fvj54l	325	13	a	a	DT
cord-005941-e4fvj54l	325	14	reduced	reduce	VBN
cord-005941-e4fvj54l	325	15	SP	SP	NNP
cord-005941-e4fvj54l	325	16	-	-	HYPH
cord-005941-e4fvj54l	325	17	A	A	NNP
cord-005941-e4fvj54l	325	18	content	content	NN
cord-005941-e4fvj54l	325	19	in	in	IN
cord-005941-e4fvj54l	325	20	the	the	DT
cord-005941-e4fvj54l	325	21	BAL	bal	NN
cord-005941-e4fvj54l	325	22	have	have	VBP
cord-005941-e4fvj54l	325	23	been	be	VBN
cord-005941-e4fvj54l	325	24	described	describe	VBN
cord-005941-e4fvj54l	325	25	in	in	IN
cord-005941-e4fvj54l	325	26	animal	animal	NN
cord-005941-e4fvj54l	325	27	models	model	NNS
cord-005941-e4fvj54l	325	28	[	[	-LRB-
cord-005941-e4fvj54l	325	29	104	104	CD
cord-005941-e4fvj54l	325	30	,	,	,
cord-005941-e4fvj54l	325	31	168	168	CD
cord-005941-e4fvj54l	325	32	]	]	-RRB-
cord-005941-e4fvj54l	325	33	and	and	CC
cord-005941-e4fvj54l	325	34	in	in	IN
cord-005941-e4fvj54l	325	35	man	man	NN
cord-005941-e4fvj54l	325	36	[	[	-LRB-
cord-005941-e4fvj54l	325	37	11	11	CD
cord-005941-e4fvj54l	325	38	,	,	,
cord-005941-e4fvj54l	325	39	61	61	CD
cord-005941-e4fvj54l	325	40	,	,	,
cord-005941-e4fvj54l	325	41	143	143	CD
cord-005941-e4fvj54l	325	42	,	,	,
cord-005941-e4fvj54l	325	43	144	144	CD
cord-005941-e4fvj54l	325	44	]	]	-RRB-
cord-005941-e4fvj54l	325	45	,	,	,
cord-005941-e4fvj54l	325	46	while	while	IN
cord-005941-e4fvj54l	325	47	the	the	DT
cord-005941-e4fvj54l	325	48	total	total	JJ
cord-005941-e4fvj54l	325	49	phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	325	50	have	have	VBP
cord-005941-e4fvj54l	325	51	not	not	RB
cord-005941-e4fvj54l	325	52	consistently	consistently	RB
cord-005941-e4fvj54l	325	53	been	be	VBN
cord-005941-e4fvj54l	325	54	found	find	VBN
cord-005941-e4fvj54l	325	55	to	to	TO
cord-005941-e4fvj54l	325	56	be	be	VB
cord-005941-e4fvj54l	325	57	reduced	reduce	VBN
cord-005941-e4fvj54l	325	58	.	.	.
cord-005941-e4fvj54l	326	1	The	the	DT
cord-005941-e4fvj54l	326	2	pathogenesis	pathogenesis	NN
cord-005941-e4fvj54l	326	3	of	of	IN
cord-005941-e4fvj54l	326	4	these	these	DT
cord-005941-e4fvj54l	326	5	changes	change	NNS
cord-005941-e4fvj54l	326	6	seems	seem	VBZ
cord-005941-e4fvj54l	326	7	complex	complex	JJ
cord-005941-e4fvj54l	326	8	and	and	CC
cord-005941-e4fvj54l	326	9	is	be	VBZ
cord-005941-e4fvj54l	326	10	still	still	RB
cord-005941-e4fvj54l	326	11	only	only	RB
cord-005941-e4fvj54l	326	12	partly	partly	RB
cord-005941-e4fvj54l	326	13	understood	understand	VBN
cord-005941-e4fvj54l	326	14	.	.	.
cord-005941-e4fvj54l	327	1	Again	again	RB
cord-005941-e4fvj54l	327	2	,	,	,
cord-005941-e4fvj54l	327	3	some	some	DT
cord-005941-e4fvj54l	327	4	of	of	IN
cord-005941-e4fvj54l	327	5	the	the	DT
cord-005941-e4fvj54l	327	6	reported	report	VBN
cord-005941-e4fvj54l	327	7	phospholipid	phospholipid	NN
cord-005941-e4fvj54l	327	8	changes	change	NNS
cord-005941-e4fvj54l	327	9	may	may	MD
cord-005941-e4fvj54l	327	10	not	not	RB
cord-005941-e4fvj54l	327	11	be	be	VB
cord-005941-e4fvj54l	327	12	directly	directly	RB
cord-005941-e4fvj54l	327	13	related	relate	VBN
cord-005941-e4fvj54l	327	14	to	to	IN
cord-005941-e4fvj54l	327	15	surfactant	surfactant	NN
cord-005941-e4fvj54l	327	16	abnormalities	abnormality	NNS
cord-005941-e4fvj54l	327	17	but	but	CC
cord-005941-e4fvj54l	327	18	may	may	MD
cord-005941-e4fvj54l	327	19	be	be	VB
cord-005941-e4fvj54l	327	20	caused	cause	VBN
cord-005941-e4fvj54l	327	21	by	by	IN
cord-005941-e4fvj54l	327	22	other	other	JJ
cord-005941-e4fvj54l	327	23	mechanisms	mechanism	NNS
cord-005941-e4fvj54l	327	24	like	like	IN
cord-005941-e4fvj54l	327	25	breakdown	breakdown	NN
cord-005941-e4fvj54l	327	26	of	of	IN
cord-005941-e4fvj54l	327	27	cell	cell	NN
cord-005941-e4fvj54l	327	28	membranes	membrane	NNS
cord-005941-e4fvj54l	327	29	.	.	.
cord-005941-e4fvj54l	328	1	One	one	CD
cord-005941-e4fvj54l	328	2	of	of	IN
cord-005941-e4fvj54l	328	3	the	the	DT
cord-005941-e4fvj54l	328	4	major	major	JJ
cord-005941-e4fvj54l	328	5	mechanisms	mechanism	NNS
cord-005941-e4fvj54l	328	6	leading	lead	VBG
cord-005941-e4fvj54l	328	7	to	to	IN
cord-005941-e4fvj54l	328	8	surfactant	surfactant	NN
cord-005941-e4fvj54l	328	9	disturbances	disturbance	NNS
cord-005941-e4fvj54l	328	10	in	in	IN
cord-005941-e4fvj54l	328	11	ARDS	ARDS	NNP
cord-005941-e4fvj54l	328	12	is	be	VBZ
cord-005941-e4fvj54l	328	13	probably	probably	RB
cord-005941-e4fvj54l	328	14	connected	connect	VBN
cord-005941-e4fvj54l	328	15	to	to	IN
cord-005941-e4fvj54l	328	16	a	a	DT
cord-005941-e4fvj54l	328	17	massive	massive	JJ
cord-005941-e4fvj54l	328	18	fluid	fluid	NN
cord-005941-e4fvj54l	328	19	and	and	CC
cord-005941-e4fvj54l	328	20	protein	protein	NN
cord-005941-e4fvj54l	328	21	accumulation	accumulation	NN
cord-005941-e4fvj54l	328	22	in	in	IN
cord-005941-e4fvj54l	328	23	the	the	DT
cord-005941-e4fvj54l	328	24	alveolar	alveolar	NNP
cord-005941-e4fvj54l	328	25	compartment	compartment	NN
cord-005941-e4fvj54l	328	26	.	.	.
cord-005941-e4fvj54l	329	1	Especially	especially	RB
cord-005941-e4fvj54l	329	2	in	in	IN
cord-005941-e4fvj54l	329	3	the	the	DT
cord-005941-e4fvj54l	329	4	early	early	JJ
cord-005941-e4fvj54l	329	5	stages	stage	NNS
cord-005941-e4fvj54l	329	6	of	of	IN
cord-005941-e4fvj54l	329	7	ARDS	ARDS	NNP
cord-005941-e4fvj54l	329	8	,	,	,
cord-005941-e4fvj54l	329	9	the	the	DT
cord-005941-e4fvj54l	329	10	increased	increase	VBN
cord-005941-e4fvj54l	329	11	permeability	permeability	NN
cord-005941-e4fvj54l	329	12	of	of	IN
cord-005941-e4fvj54l	329	13	the	the	DT
cord-005941-e4fvj54l	329	14	alveolocapillary	alveolocapillary	JJ
cord-005941-e4fvj54l	329	15	barrier	barrier	NN
cord-005941-e4fvj54l	329	16	leads	lead	VBZ
cord-005941-e4fvj54l	329	17	to	to	IN
cord-005941-e4fvj54l	329	18	noncardiogenic	noncardiogenic	JJ
cord-005941-e4fvj54l	329	19	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	329	20	edema	edema	NN
cord-005941-e4fvj54l	329	21	with	with	IN
cord-005941-e4fvj54l	329	22	high	high	JJ
cord-005941-e4fvj54l	329	23	concentrations	concentration	NNS
cord-005941-e4fvj54l	329	24	of	of	IN
cord-005941-e4fvj54l	329	25	plasma	plasma	NN
cord-005941-e4fvj54l	329	26	-	-	HYPH
cord-005941-e4fvj54l	329	27	derived	derive	VBN
cord-005941-e4fvj54l	329	28	proteins	protein	NNS
cord-005941-e4fvj54l	329	29	.	.	.
cord-005941-e4fvj54l	330	1	Edema	edema	NN
cord-005941-e4fvj54l	330	2	fluid	fluid	NN
cord-005941-e4fvj54l	330	3	and	and	CC
cord-005941-e4fvj54l	330	4	coagulated	coagulated	JJ
cord-005941-e4fvj54l	330	5	proteins	protein	NNS
cord-005941-e4fvj54l	330	6	block	block	VBP
cord-005941-e4fvj54l	330	7	the	the	DT
cord-005941-e4fvj54l	330	8	alveolar	alveolar	JJ
cord-005941-e4fvj54l	330	9	air	air	NN
cord-005941-e4fvj54l	330	10	spaces	space	NNS
cord-005941-e4fvj54l	330	11	and	and	CC
cord-005941-e4fvj54l	330	12	impair	impair	VB
cord-005941-e4fvj54l	330	13	normal	normal	JJ
cord-005941-e4fvj54l	330	14	gas	gas	NN
cord-005941-e4fvj54l	330	15	exchange	exchange	NN
cord-005941-e4fvj54l	330	16	[	[	-LRB-
cord-005941-e4fvj54l	330	17	36	36	CD
cord-005941-e4fvj54l	330	18	,	,	,
cord-005941-e4fvj54l	330	19	161	161	CD
cord-005941-e4fvj54l	330	20	]	]	-RRB-
cord-005941-e4fvj54l	330	21	.	.	.
cord-005941-e4fvj54l	331	1	Several	several	JJ
cord-005941-e4fvj54l	331	2	lines	line	NNS
cord-005941-e4fvj54l	331	3	of	of	IN
cord-005941-e4fvj54l	331	4	evidence	evidence	NN
cord-005941-e4fvj54l	331	5	suggest	suggest	VBP
cord-005941-e4fvj54l	331	6	that	that	IN
cord-005941-e4fvj54l	331	7	many	many	JJ
cord-005941-e4fvj54l	331	8	of	of	IN
cord-005941-e4fvj54l	331	9	these	these	DT
cord-005941-e4fvj54l	331	10	plasmaderived	plasmaderive	VBN
cord-005941-e4fvj54l	331	11	proteins	protein	NNS
cord-005941-e4fvj54l	331	12	also	also	RB
cord-005941-e4fvj54l	331	13	have	have	VBP
cord-005941-e4fvj54l	331	14	a	a	DT
cord-005941-e4fvj54l	331	15	strong	strong	JJ
cord-005941-e4fvj54l	331	16	potential	potential	NN
cord-005941-e4fvj54l	331	17	for	for	IN
cord-005941-e4fvj54l	331	18	inactivation	inactivation	NN
cord-005941-e4fvj54l	331	19	of	of	IN
cord-005941-e4fvj54l	331	20	surfactant	surfactant	NN
cord-005941-e4fvj54l	331	21	material	material	NN
cord-005941-e4fvj54l	331	22	[	[	-LRB-
cord-005941-e4fvj54l	331	23	71	71	CD
cord-005941-e4fvj54l	331	24	,	,	,
cord-005941-e4fvj54l	331	25	97	97	CD
cord-005941-e4fvj54l	331	26	,	,	,
cord-005941-e4fvj54l	331	27	161	161	CD
cord-005941-e4fvj54l	331	28	]	]	-RRB-
cord-005941-e4fvj54l	331	29	.	.	.
cord-005941-e4fvj54l	332	1	In	in	IN
cord-005941-e4fvj54l	332	2	detail	detail	NN
cord-005941-e4fvj54l	332	3	,	,	,
cord-005941-e4fvj54l	332	4	this	this	DT
cord-005941-e4fvj54l	332	5	has	have	VBZ
cord-005941-e4fvj54l	332	6	been	be	VBN
cord-005941-e4fvj54l	332	7	experimentally	experimentally	RB
cord-005941-e4fvj54l	332	8	demonstrated	demonstrate	VBN
cord-005941-e4fvj54l	332	9	for	for	IN
cord-005941-e4fvj54l	332	10	fibrinogen	fibrinogen	NN
cord-005941-e4fvj54l	332	11	[	[	-LRB-
cord-005941-e4fvj54l	332	12	46	46	CD
cord-005941-e4fvj54l	332	13	]	]	-RRB-
cord-005941-e4fvj54l	332	14	,	,	,
cord-005941-e4fvj54l	332	15	fibrin	fibrin	NN
cord-005941-e4fvj54l	332	16	monomers	monomer	NNS
cord-005941-e4fvj54l	333	1	[	[	-LRB-
cord-005941-e4fvj54l	333	2	160	160	CD
cord-005941-e4fvj54l	333	3	]	]	-RRB-
cord-005941-e4fvj54l	333	4	albumin	albumin	NN
cord-005941-e4fvj54l	333	5	[	[	-LRB-
cord-005941-e4fvj54l	333	6	73	73	CD
cord-005941-e4fvj54l	333	7	]	]	-RRB-
cord-005941-e4fvj54l	333	8	,	,	,
cord-005941-e4fvj54l	333	9	and	and	CC
cord-005941-e4fvj54l	333	10	even	even	RB
cord-005941-e4fvj54l	333	11	hemoglobin	hemoglobin	NN
cord-005941-e4fvj54l	333	12	[	[	-LRB-
cord-005941-e4fvj54l	333	13	72	72	CD
cord-005941-e4fvj54l	333	14	]	]	-RRB-
cord-005941-e4fvj54l	333	15	.	.	.
cord-005941-e4fvj54l	334	1	These	these	DT
cord-005941-e4fvj54l	334	2	results	result	NNS
cord-005941-e4fvj54l	334	3	suggest	suggest	VBP
cord-005941-e4fvj54l	334	4	that	that	IN
cord-005941-e4fvj54l	334	5	in	in	IN
cord-005941-e4fvj54l	334	6	ARDS	ARDS	NNP
cord-005941-e4fvj54l	334	7	a	a	DT
cord-005941-e4fvj54l	334	8	major	major	JJ
cord-005941-e4fvj54l	334	9	problem	problem	NN
cord-005941-e4fvj54l	334	10	is	be	VBZ
cord-005941-e4fvj54l	334	11	probably	probably	RB
cord-005941-e4fvj54l	334	12	not	not	RB
cord-005941-e4fvj54l	334	13	only	only	RB
cord-005941-e4fvj54l	334	14	the	the	DT
cord-005941-e4fvj54l	334	15	postulated	postulate	VBN
cord-005941-e4fvj54l	334	16	deficit	deficit	NN
cord-005941-e4fvj54l	334	17	of	of	IN
cord-005941-e4fvj54l	334	18	alveolar	alveolar	JJ
cord-005941-e4fvj54l	334	19	type	type	NN
cord-005941-e4fvj54l	334	20	II	II	NNP
cord-005941-e4fvj54l	334	21	cell	cell	NN
cord-005941-e4fvj54l	334	22	function	function	NN
cord-005941-e4fvj54l	334	23	but	but	CC
cord-005941-e4fvj54l	334	24	also	also	RB
cord-005941-e4fvj54l	334	25	a	a	DT
cord-005941-e4fvj54l	334	26	relative	relative	JJ
cord-005941-e4fvj54l	334	27	deficit	deficit	NN
cord-005941-e4fvj54l	334	28	of	of	IN
cord-005941-e4fvj54l	334	29	functionally	functionally	RB
cord-005941-e4fvj54l	334	30	intact	intact	JJ
cord-005941-e4fvj54l	334	31	surfactant	surfactant	NN
cord-005941-e4fvj54l	334	32	material	material	NN
cord-005941-e4fvj54l	334	33	due	due	IN
cord-005941-e4fvj54l	334	34	to	to	IN
cord-005941-e4fvj54l	334	35	massive	massive	JJ
cord-005941-e4fvj54l	334	36	protein	protein	NN
cord-005941-e4fvj54l	334	37	inactivation	inactivation	NN
cord-005941-e4fvj54l	334	38	.	.	.
cord-005941-e4fvj54l	335	1	It	-PRON-	PRP
cord-005941-e4fvj54l	335	2	remains	remain	VBZ
cord-005941-e4fvj54l	335	3	to	to	TO
cord-005941-e4fvj54l	335	4	be	be	VB
cord-005941-e4fvj54l	335	5	investigated	investigate	VBN
cord-005941-e4fvj54l	335	6	whether	whether	IN
cord-005941-e4fvj54l	335	7	or	or	CC
cord-005941-e4fvj54l	335	8	not	not	RB
cord-005941-e4fvj54l	335	9	the	the	DT
cord-005941-e4fvj54l	335	10	protein	protein	NN
cord-005941-e4fvj54l	335	11	inactivation	inactivation	NN
cord-005941-e4fvj54l	335	12	of	of	IN
cord-005941-e4fvj54l	335	13	alveolar	alveolar	NN
cord-005941-e4fvj54l	335	14	surfactant	surfactant	NN
cord-005941-e4fvj54l	335	15	is	be	VBZ
cord-005941-e4fvj54l	335	16	,	,	,
cord-005941-e4fvj54l	335	17	to	to	IN
cord-005941-e4fvj54l	335	18	a	a	DT
cord-005941-e4fvj54l	335	19	minor	minor	JJ
cord-005941-e4fvj54l	335	20	degree	degree	NN
cord-005941-e4fvj54l	335	21	,	,	,
cord-005941-e4fvj54l	335	22	also	also	RB
cord-005941-e4fvj54l	335	23	relevant	relevant	JJ
cord-005941-e4fvj54l	335	24	to	to	IN
cord-005941-e4fvj54l	335	25	other	other	JJ
cord-005941-e4fvj54l	335	26	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	335	27	diseases	disease	NNS
cord-005941-e4fvj54l	335	28	.	.	.
cord-005941-e4fvj54l	336	1	Another	another	DT
cord-005941-e4fvj54l	336	2	possible	possible	JJ
cord-005941-e4fvj54l	336	3	mechanism	mechanism	NN
cord-005941-e4fvj54l	336	4	of	of	IN
cord-005941-e4fvj54l	336	5	surfactant	surfactant	NN
cord-005941-e4fvj54l	336	6	inactivation	inactivation	NN
cord-005941-e4fvj54l	336	7	in	in	IN
cord-005941-e4fvj54l	336	8	ARDS	ARDS	NNP
cord-005941-e4fvj54l	336	9	is	be	VBZ
cord-005941-e4fvj54l	336	10	that	that	IN
cord-005941-e4fvj54l	336	11	surfactant	surfactant	NN
cord-005941-e4fvj54l	336	12	phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	336	13	may	may	MD
cord-005941-e4fvj54l	336	14	be	be	VB
cord-005941-e4fvj54l	336	15	degraded	degrade	VBN
cord-005941-e4fvj54l	336	16	by	by	IN
cord-005941-e4fvj54l	336	17	phospholipase	phospholipase	NN
cord-005941-e4fvj54l	336	18	A2	A2	NNP
cord-005941-e4fvj54l	336	19	,	,	,
cord-005941-e4fvj54l	336	20	an	an	DT
cord-005941-e4fvj54l	336	21	enzyme	enzyme	NN
cord-005941-e4fvj54l	336	22	which	which	WDT
cord-005941-e4fvj54l	336	23	is	be	VBZ
cord-005941-e4fvj54l	336	24	probably	probably	RB
cord-005941-e4fvj54l	336	25	involved	involve	VBN
cord-005941-e4fvj54l	336	26	in	in	IN
cord-005941-e4fvj54l	336	27	ARDS	ARDS	NNP
cord-005941-e4fvj54l	336	28	caused	cause	VBN
cord-005941-e4fvj54l	336	29	by	by	IN
cord-005941-e4fvj54l	336	30	pancreatitis	pancreatitis	NN
cord-005941-e4fvj54l	336	31	or	or	CC
cord-005941-e4fvj54l	336	32	sepsis	sepsis	NN
cord-005941-e4fvj54l	336	33	[	[	-LRB-
cord-005941-e4fvj54l	336	34	35	35	CD
cord-005941-e4fvj54l	336	35	,	,	,
cord-005941-e4fvj54l	336	36	82	82	CD
cord-005941-e4fvj54l	336	37	]	]	-RRB-
cord-005941-e4fvj54l	336	38	.	.	.
cord-005941-e4fvj54l	337	1	Furthermore	furthermore	RB
cord-005941-e4fvj54l	337	2	,	,	,
cord-005941-e4fvj54l	337	3	it	-PRON-	PRP
cord-005941-e4fvj54l	337	4	has	have	VBZ
cord-005941-e4fvj54l	337	5	been	be	VBN
cord-005941-e4fvj54l	337	6	shown	show	VBN
cord-005941-e4fvj54l	337	7	that	that	IN
cord-005941-e4fvj54l	337	8	E.	E.	NNP
cord-005941-e4fvj54l	337	9	coli	coli	NN
cord-005941-e4fvj54l	337	10	endotoxin	endotoxin	NN
cord-005941-e4fvj54l	337	11	reduces	reduce	VBZ
cord-005941-e4fvj54l	337	12	surfactant	surfactant	NN
cord-005941-e4fvj54l	337	13	synthesis	synthesis	NN
cord-005941-e4fvj54l	337	14	in	in	IN
cord-005941-e4fvj54l	337	15	vitro	vitro	FW
cord-005941-e4fvj54l	337	16	[	[	-LRB-
cord-005941-e4fvj54l	337	17	103	103	CD
cord-005941-e4fvj54l	337	18	]	]	-RRB-
cord-005941-e4fvj54l	337	19	and	and	CC
cord-005941-e4fvj54l	337	20	in	in	IN
cord-005941-e4fvj54l	337	21	vivo	vivo	NNP
cord-005941-e4fvj54l	337	22	[	[	-LRB-
cord-005941-e4fvj54l	337	23	130	130	CD
cord-005941-e4fvj54l	337	24	]	]	-RRB-
cord-005941-e4fvj54l	337	25	.	.	.
cord-005941-e4fvj54l	338	1	Many	many	JJ
cord-005941-e4fvj54l	338	2	authors	author	NNS
cord-005941-e4fvj54l	338	3	have	have	VBP
cord-005941-e4fvj54l	338	4	called	call	VBN
cord-005941-e4fvj54l	338	5	for	for	IN
cord-005941-e4fvj54l	338	6	clinical	clinical	JJ
cord-005941-e4fvj54l	338	7	studies	study	NNS
cord-005941-e4fvj54l	338	8	to	to	TO
cord-005941-e4fvj54l	338	9	investigate	investigate	VB
cord-005941-e4fvj54l	338	10	the	the	DT
cord-005941-e4fvj54l	338	11	benefit	benefit	NN
cord-005941-e4fvj54l	338	12	of	of	IN
cord-005941-e4fvj54l	338	13	surfactant	surfactant	NN
cord-005941-e4fvj54l	338	14	substitution	substitution	NN
cord-005941-e4fvj54l	338	15	therapy	therapy	NN
cord-005941-e4fvj54l	338	16	in	in	IN
cord-005941-e4fvj54l	338	17	ARDS	ARDS	NNP
cord-005941-e4fvj54l	338	18	[	[	-LRB-
cord-005941-e4fvj54l	338	19	36	36	CD
cord-005941-e4fvj54l	338	20	,	,	,
cord-005941-e4fvj54l	338	21	100	100	CD
cord-005941-e4fvj54l	338	22	,	,	,
cord-005941-e4fvj54l	338	23	112	112	CD
cord-005941-e4fvj54l	338	24	,	,	,
cord-005941-e4fvj54l	338	25	125	125	CD
cord-005941-e4fvj54l	338	26	]	]	-RRB-
cord-005941-e4fvj54l	338	27	,	,	,
cord-005941-e4fvj54l	338	28	but	but	CC
cord-005941-e4fvj54l	338	29	there	there	EX
cord-005941-e4fvj54l	338	30	are	be	VBP
cord-005941-e4fvj54l	338	31	still	still	RB
cord-005941-e4fvj54l	338	32	numerous	numerous	JJ
cord-005941-e4fvj54l	338	33	problems	problem	NNS
cord-005941-e4fvj54l	338	34	to	to	TO
cord-005941-e4fvj54l	338	35	be	be	VB
cord-005941-e4fvj54l	338	36	solved	solve	VBN
cord-005941-e4fvj54l	338	37	like	like	IN
cord-005941-e4fvj54l	338	38	dosage	dosage	NN
cord-005941-e4fvj54l	338	39	,	,	,
cord-005941-e4fvj54l	338	40	timing	timing	NN
cord-005941-e4fvj54l	338	41	,	,	,
cord-005941-e4fvj54l	338	42	and	and	CC
cord-005941-e4fvj54l	338	43	delivery	delivery	NN
cord-005941-e4fvj54l	338	44	method	method	NN
cord-005941-e4fvj54l	338	45	[	[	-LRB-
cord-005941-e4fvj54l	338	46	71	71	CD
cord-005941-e4fvj54l	338	47	]	]	-RRB-
cord-005941-e4fvj54l	338	48	which	which	WDT
cord-005941-e4fvj54l	338	49	dampen	dampen	VBP
cord-005941-e4fvj54l	338	50	the	the	DT
cord-005941-e4fvj54l	338	51	enthusiasm	enthusiasm	NN
cord-005941-e4fvj54l	338	52	for	for	IN
cord-005941-e4fvj54l	338	53	patient	patient	JJ
cord-005941-e4fvj54l	338	54	trials	trial	NNS
cord-005941-e4fvj54l	338	55	.	.	.
cord-005941-e4fvj54l	339	1	Much	much	JJ
cord-005941-e4fvj54l	339	2	of	of	IN
cord-005941-e4fvj54l	339	3	the	the	DT
cord-005941-e4fvj54l	339	4	optimism	optimism	NN
cord-005941-e4fvj54l	339	5	is	be	VBZ
cord-005941-e4fvj54l	339	6	certainly	certainly	RB
cord-005941-e4fvj54l	339	7	due	due	JJ
cord-005941-e4fvj54l	339	8	to	to	IN
cord-005941-e4fvj54l	339	9	the	the	DT
cord-005941-e4fvj54l	339	10	fact	fact	NN
cord-005941-e4fvj54l	339	11	that	that	IN
cord-005941-e4fvj54l	339	12	ARDS	ARDS	NNP
cord-005941-e4fvj54l	339	13	shares	share	VBZ
cord-005941-e4fvj54l	339	14	common	common	JJ
cord-005941-e4fvj54l	339	15	features	feature	NNS
cord-005941-e4fvj54l	339	16	with	with	IN
cord-005941-e4fvj54l	339	17	IRDS	IRDS	NNP
cord-005941-e4fvj54l	339	18	in	in	IN
cord-005941-e4fvj54l	339	19	which	which	WDT
cord-005941-e4fvj54l	339	20	surfactant	surfactant	NN
cord-005941-e4fvj54l	339	21	replacement	replacement	NN
cord-005941-e4fvj54l	339	22	is	be	VBZ
cord-005941-e4fvj54l	339	23	on	on	IN
cord-005941-e4fvj54l	339	24	the	the	DT
cord-005941-e4fvj54l	339	25	verge	verge	NN
cord-005941-e4fvj54l	339	26	of	of	IN
cord-005941-e4fvj54l	339	27	becoming	become	VBG
cord-005941-e4fvj54l	339	28	a	a	DT
cord-005941-e4fvj54l	339	29	standard	standard	JJ
cord-005941-e4fvj54l	339	30	therapy	therapy	NN
cord-005941-e4fvj54l	339	31	.	.	.
cord-005941-e4fvj54l	340	1	Additionally	additionally	RB
cord-005941-e4fvj54l	340	2	,	,	,
cord-005941-e4fvj54l	340	3	animal	animal	NN
cord-005941-e4fvj54l	340	4	studies	study	NNS
cord-005941-e4fvj54l	340	5	(	(	-LRB-
cord-005941-e4fvj54l	340	6	e.g.	e.g.	RB
cord-005941-e4fvj54l	340	7	,	,	,
cord-005941-e4fvj54l	340	8	[	[	-LRB-
cord-005941-e4fvj54l	340	9	101	101	CD
cord-005941-e4fvj54l	340	10	]	]	-RRB-
cord-005941-e4fvj54l	340	11	)	)	-RRB-
cord-005941-e4fvj54l	340	12	and	and	CC
cord-005941-e4fvj54l	340	13	human	human	JJ
cord-005941-e4fvj54l	340	14	case	case	NN
cord-005941-e4fvj54l	340	15	reports	report	NNS
cord-005941-e4fvj54l	340	16	[	[	-LRB-
cord-005941-e4fvj54l	340	17	85	85	CD
cord-005941-e4fvj54l	340	18	,	,	,
cord-005941-e4fvj54l	340	19	100	100	CD
cord-005941-e4fvj54l	340	20	,	,	,
cord-005941-e4fvj54l	340	21	127	127	CD
cord-005941-e4fvj54l	340	22	,	,	,
cord-005941-e4fvj54l	340	23	152	152	CD
cord-005941-e4fvj54l	340	24	]	]	-RRB-
cord-005941-e4fvj54l	340	25	support	support	VBP
cord-005941-e4fvj54l	340	26	the	the	DT
cord-005941-e4fvj54l	340	27	hope	hope	NN
cord-005941-e4fvj54l	340	28	for	for	IN
cord-005941-e4fvj54l	340	29	a	a	DT
cord-005941-e4fvj54l	340	30	beneficial	beneficial	JJ
cord-005941-e4fvj54l	340	31	effect	effect	NN
cord-005941-e4fvj54l	340	32	of	of	IN
cord-005941-e4fvj54l	340	33	surfactant	surfactant	NN
cord-005941-e4fvj54l	340	34	replacement	replacement	NN
cord-005941-e4fvj54l	340	35	therapy	therapy	NN
cord-005941-e4fvj54l	340	36	in	in	IN
cord-005941-e4fvj54l	340	37	ARDS	ARDS	NNP
cord-005941-e4fvj54l	340	38	.	.	.
cord-005941-e4fvj54l	341	1	The	the	DT
cord-005941-e4fvj54l	341	2	first	first	JJ
cord-005941-e4fvj54l	341	3	controlled	control	VBN
cord-005941-e4fvj54l	341	4	clinical	clinical	JJ
cord-005941-e4fvj54l	341	5	trials	trial	NNS
cord-005941-e4fvj54l	341	6	are	be	VBP
cord-005941-e4fvj54l	341	7	presently	presently	RB
cord-005941-e4fvj54l	341	8	under	under	IN
cord-005941-e4fvj54l	341	9	way	way	NN
cord-005941-e4fvj54l	341	10	.	.	.
cord-005941-e4fvj54l	342	1	Even	even	RB
cord-005941-e4fvj54l	342	2	if	if	IN
cord-005941-e4fvj54l	342	3	beneficial	beneficial	JJ
cord-005941-e4fvj54l	342	4	effects	effect	NNS
cord-005941-e4fvj54l	342	5	on	on	IN
cord-005941-e4fvj54l	342	6	survival	survival	NN
cord-005941-e4fvj54l	342	7	can	can	MD
cord-005941-e4fvj54l	342	8	be	be	VB
cord-005941-e4fvj54l	342	9	demon	demon	NN
cord-005941-e4fvj54l	342	10	-	-	HYPH
cord-005941-e4fvj54l	342	11	strated	strate	VBN
cord-005941-e4fvj54l	342	12	,	,	,
cord-005941-e4fvj54l	342	13	a	a	DT
cord-005941-e4fvj54l	342	14	significant	significant	JJ
cord-005941-e4fvj54l	342	15	mortality	mortality	NN
cord-005941-e4fvj54l	342	16	will	will	MD
cord-005941-e4fvj54l	342	17	probably	probably	RB
cord-005941-e4fvj54l	342	18	remain	remain	VB
cord-005941-e4fvj54l	342	19	,	,	,
cord-005941-e4fvj54l	342	20	since	since	IN
cord-005941-e4fvj54l	342	21	the	the	DT
cord-005941-e4fvj54l	342	22	cause	cause	NN
cord-005941-e4fvj54l	342	23	of	of	IN
cord-005941-e4fvj54l	342	24	death	death	NN
cord-005941-e4fvj54l	342	25	in	in	IN
cord-005941-e4fvj54l	342	26	ARDS	ARDS	NNP
cord-005941-e4fvj54l	342	27	is	be	VBZ
cord-005941-e4fvj54l	342	28	not	not	RB
cord-005941-e4fvj54l	342	29	invariably	invariably	RB
cord-005941-e4fvj54l	342	30	related	relate	VBN
cord-005941-e4fvj54l	342	31	to	to	IN
cord-005941-e4fvj54l	342	32	respiratory	respiratory	JJ
cord-005941-e4fvj54l	342	33	failure	failure	NN
cord-005941-e4fvj54l	342	34	[	[	-LRB-
cord-005941-e4fvj54l	342	35	121	121	CD
cord-005941-e4fvj54l	342	36	]	]	-RRB-
cord-005941-e4fvj54l	342	37	.	.	.
cord-005941-e4fvj54l	343	1	Idiopathic	idiopathic	JJ
cord-005941-e4fvj54l	343	2	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	343	3	fibrosis	fibrosis	NN
cord-005941-e4fvj54l	343	4	(	(	-LRB-
cord-005941-e4fvj54l	343	5	IPF	IPF	NNP
cord-005941-e4fvj54l	343	6	)	)	-RRB-
cord-005941-e4fvj54l	343	7	is	be	VBZ
cord-005941-e4fvj54l	343	8	a	a	DT
cord-005941-e4fvj54l	343	9	progressive	progressive	JJ
cord-005941-e4fvj54l	343	10	fibrosing	fibrose	VBG
cord-005941-e4fvj54l	343	11	lung	lung	NN
cord-005941-e4fvj54l	343	12	disease	disease	NN
cord-005941-e4fvj54l	343	13	of	of	IN
cord-005941-e4fvj54l	343	14	unknown	unknown	JJ
cord-005941-e4fvj54l	343	15	origin	origin	NN
cord-005941-e4fvj54l	343	16	which	which	WDT
cord-005941-e4fvj54l	343	17	involves	involve	VBZ
cord-005941-e4fvj54l	343	18	alveolar	alveolar	JJ
cord-005941-e4fvj54l	343	19	epithelial	epithelial	JJ
cord-005941-e4fvj54l	343	20	injury	injury	NN
cord-005941-e4fvj54l	343	21	and	and	CC
cord-005941-e4fvj54l	343	22	alveolar	alveolar	NN
cord-005941-e4fvj54l	343	23	type	type	NN
cord-005941-e4fvj54l	343	24	II	II	NNP
cord-005941-e4fvj54l	343	25	cell	cell	NN
cord-005941-e4fvj54l	343	26	proliferation	proliferation	NN
cord-005941-e4fvj54l	343	27	[	[	-LRB-
cord-005941-e4fvj54l	343	28	91	91	CD
cord-005941-e4fvj54l	343	29	]	]	-RRB-
cord-005941-e4fvj54l	343	30	.	.	.
cord-005941-e4fvj54l	344	1	Total	total	JJ
cord-005941-e4fvj54l	344	2	phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	344	3	in	in	IN
cord-005941-e4fvj54l	344	4	BAL	BAL	NNP
cord-005941-e4fvj54l	344	5	were	be	VBD
cord-005941-e4fvj54l	344	6	found	find	VBN
cord-005941-e4fvj54l	344	7	to	to	TO
cord-005941-e4fvj54l	344	8	be	be	VB
cord-005941-e4fvj54l	344	9	reduced	reduce	VBN
cord-005941-e4fvj54l	344	10	,	,	,
cord-005941-e4fvj54l	344	11	with	with	IN
cord-005941-e4fvj54l	344	12	decreases	decrease	NNS
cord-005941-e4fvj54l	344	13	of	of	IN
cord-005941-e4fvj54l	344	14	PG	PG	NNP
cord-005941-e4fvj54l	344	15	and	and	CC
cord-005941-e4fvj54l	344	16	DPPC	DPPC	NNP
cord-005941-e4fvj54l	344	17	and	and	CC
cord-005941-e4fvj54l	344	18	an	an	DT
cord-005941-e4fvj54l	344	19	increase	increase	NN
cord-005941-e4fvj54l	344	20	in	in	IN
cord-005941-e4fvj54l	344	21	PI	PI	NNP
cord-005941-e4fvj54l	344	22	[	[	-LRB-
cord-005941-e4fvj54l	344	23	76	76	CD
cord-005941-e4fvj54l	344	24	]	]	-RRB-
cord-005941-e4fvj54l	344	25	.	.	.
cord-005941-e4fvj54l	345	1	Another	another	DT
cord-005941-e4fvj54l	345	2	study	study	NN
cord-005941-e4fvj54l	345	3	[	[	-LRB-
cord-005941-e4fvj54l	345	4	154	154	CD
cord-005941-e4fvj54l	345	5	]	]	-RRB-
cord-005941-e4fvj54l	345	6	reported	report	VBD
cord-005941-e4fvj54l	345	7	similar	similar	JJ
cord-005941-e4fvj54l	345	8	findings	finding	NNS
cord-005941-e4fvj54l	345	9	in	in	IN
cord-005941-e4fvj54l	345	10	15	15	CD
cord-005941-e4fvj54l	345	11	untreated	untreated	JJ
cord-005941-e4fvj54l	345	12	patients	patient	NNS
cord-005941-e4fvj54l	345	13	.	.	.
cord-005941-e4fvj54l	346	1	Total	total	JJ
cord-005941-e4fvj54l	346	2	phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	346	3	in	in	IN
cord-005941-e4fvj54l	346	4	BAL	BAL	NNP
cord-005941-e4fvj54l	346	5	were	be	VBD
cord-005941-e4fvj54l	346	6	less	less	JJR
cord-005941-e4fvj54l	346	7	than	than	IN
cord-005941-e4fvj54l	346	8	half	half	PDT
cord-005941-e4fvj54l	346	9	that	that	DT
cord-005941-e4fvj54l	346	10	of	of	IN
cord-005941-e4fvj54l	346	11	controls	control	NNS
cord-005941-e4fvj54l	346	12	,	,	,
cord-005941-e4fvj54l	346	13	with	with	IN
cord-005941-e4fvj54l	346	14	raised	raise	VBN
cord-005941-e4fvj54l	346	15	percentages	percentage	NNS
cord-005941-e4fvj54l	346	16	of	of	IN
cord-005941-e4fvj54l	346	17	PI	PI	NNP
cord-005941-e4fvj54l	346	18	and	and	CC
cord-005941-e4fvj54l	346	19	lowered	lower	VBD
cord-005941-e4fvj54l	346	20	PG	PG	NNP
cord-005941-e4fvj54l	346	21	.	.	.
cord-005941-e4fvj54l	347	1	The	the	DT
cord-005941-e4fvj54l	347	2	severity	severity	NN
cord-005941-e4fvj54l	347	3	of	of	IN
cord-005941-e4fvj54l	347	4	these	these	DT
cord-005941-e4fvj54l	347	5	changes	change	NNS
cord-005941-e4fvj54l	347	6	correlated	correlate	VBN
cord-005941-e4fvj54l	347	7	with	with	IN
cord-005941-e4fvj54l	347	8	more	more	RBR
cord-005941-e4fvj54l	347	9	advanced	advanced	JJ
cord-005941-e4fvj54l	347	10	histopathologic	histopathologic	JJ
cord-005941-e4fvj54l	347	11	fibrosis	fibrosis	NN
cord-005941-e4fvj54l	347	12	.	.	.
cord-005941-e4fvj54l	348	1	In	in	IN
cord-005941-e4fvj54l	348	2	28	28	CD
cord-005941-e4fvj54l	348	3	patients	patient	NNS
cord-005941-e4fvj54l	348	4	(	(	-LRB-
cord-005941-e4fvj54l	348	5	including	include	VBG
cord-005941-e4fvj54l	348	6	the	the	DT
cord-005941-e4fvj54l	348	7	15	15	CD
cord-005941-e4fvj54l	348	8	patients	patient	NNS
cord-005941-e4fvj54l	348	9	of	of	IN
cord-005941-e4fvj54l	348	10	the	the	DT
cord-005941-e4fvj54l	348	11	former	former	JJ
cord-005941-e4fvj54l	348	12	study	study	NN
cord-005941-e4fvj54l	348	13	)	)	-RRB-
cord-005941-e4fvj54l	348	14	,	,	,
cord-005941-e4fvj54l	348	15	the	the	DT
cord-005941-e4fvj54l	348	16	SP	SP	NNP
cord-005941-e4fvj54l	348	17	-	-	HYPH
cord-005941-e4fvj54l	348	18	A	A	NNP
cord-005941-e4fvj54l	348	19	content	content	NN
cord-005941-e4fvj54l	348	20	of	of	IN
cord-005941-e4fvj54l	348	21	BAL	BAL	NNP
cord-005941-e4fvj54l	348	22	was	be	VBD
cord-005941-e4fvj54l	348	23	reported	report	VBN
cord-005941-e4fvj54l	348	24	to	to	TO
cord-005941-e4fvj54l	348	25	be	be	VB
cord-005941-e4fvj54l	348	26	significantly	significantly	RB
cord-005941-e4fvj54l	348	27	lower	low	JJR
cord-005941-e4fvj54l	348	28	than	than	IN
cord-005941-e4fvj54l	348	29	in	in	IN
cord-005941-e4fvj54l	348	30	normal	normal	JJ
cord-005941-e4fvj54l	348	31	controls	control	NNS
cord-005941-e4fvj54l	348	32	[	[	-LRB-
cord-005941-e4fvj54l	348	33	116	116	CD
cord-005941-e4fvj54l	348	34	]	]	-RRB-
cord-005941-e4fvj54l	348	35	.	.	.
cord-005941-e4fvj54l	349	1	In	in	IN
cord-005941-e4fvj54l	349	2	32	32	CD
cord-005941-e4fvj54l	349	3	patients	patient	NNS
cord-005941-e4fvj54l	349	4	with	with	IN
cord-005941-e4fvj54l	349	5	untreated	untreated	JJ
cord-005941-e4fvj54l	349	6	IPF	IPF	NNP
cord-005941-e4fvj54l	349	7	,	,	,
cord-005941-e4fvj54l	349	8	the	the	DT
cord-005941-e4fvj54l	349	9	PG	PG	NNP
cord-005941-e4fvj54l	349	10	level	level	NN
cord-005941-e4fvj54l	349	11	was	be	VBD
cord-005941-e4fvj54l	349	12	lowered	lower	VBN
cord-005941-e4fvj54l	349	13	,	,	,
cord-005941-e4fvj54l	349	14	and	and	CC
cord-005941-e4fvj54l	349	15	its	-PRON-	PRP$
cord-005941-e4fvj54l	349	16	increase	increase	NN
cord-005941-e4fvj54l	349	17	after	after	IN
cord-005941-e4fvj54l	349	18	the	the	DT
cord-005941-e4fvj54l	349	19	commencement	commencement	NN
cord-005941-e4fvj54l	349	20	of	of	IN
cord-005941-e4fvj54l	349	21	steroid	steroid	NN
cord-005941-e4fvj54l	349	22	therapy	therapy	NN
cord-005941-e4fvj54l	349	23	seemed	seem	VBD
cord-005941-e4fvj54l	349	24	to	to	TO
cord-005941-e4fvj54l	349	25	indicate	indicate	VB
cord-005941-e4fvj54l	349	26	clinical	clinical	JJ
cord-005941-e4fvj54l	349	27	improvement	improvement	NN
cord-005941-e4fvj54l	349	28	[	[	-LRB-
cord-005941-e4fvj54l	349	29	81	81	CD
cord-005941-e4fvj54l	349	30	]	]	-RRB-
cord-005941-e4fvj54l	349	31	.	.	.
cord-005941-e4fvj54l	350	1	These	these	DT
cord-005941-e4fvj54l	350	2	studies	study	NNS
cord-005941-e4fvj54l	350	3	suggest	suggest	VBP
cord-005941-e4fvj54l	350	4	that	that	IN
cord-005941-e4fvj54l	350	5	surfactant	surfactant	NN
cord-005941-e4fvj54l	350	6	studies	study	NNS
cord-005941-e4fvj54l	350	7	may	may	MD
cord-005941-e4fvj54l	350	8	be	be	VB
cord-005941-e4fvj54l	350	9	of	of	IN
cord-005941-e4fvj54l	350	10	clinical	clinical	JJ
cord-005941-e4fvj54l	350	11	value	value	NN
cord-005941-e4fvj54l	350	12	to	to	TO
cord-005941-e4fvj54l	350	13	assess	assess	VB
cord-005941-e4fvj54l	350	14	the	the	DT
cord-005941-e4fvj54l	350	15	prognosis	prognosis	NN
cord-005941-e4fvj54l	350	16	and	and	CC
cord-005941-e4fvj54l	350	17	proper	proper	JJ
cord-005941-e4fvj54l	350	18	management	management	NN
cord-005941-e4fvj54l	350	19	in	in	IN
cord-005941-e4fvj54l	350	20	IPF	IPF	NNP
cord-005941-e4fvj54l	350	21	[	[	-LRB-
cord-005941-e4fvj54l	350	22	107	107	CD
cord-005941-e4fvj54l	350	23	]	]	-RRB-
cord-005941-e4fvj54l	350	24	.	.	.
cord-005941-e4fvj54l	351	1	Sarcoidosis	sarcoidosis	NN
cord-005941-e4fvj54l	351	2	is	be	VBZ
cord-005941-e4fvj54l	351	3	a	a	DT
cord-005941-e4fvj54l	351	4	generalized	generalized	JJ
cord-005941-e4fvj54l	351	5	granulomatous	granulomatous	JJ
cord-005941-e4fvj54l	351	6	disease	disease	NN
cord-005941-e4fvj54l	351	7	of	of	IN
cord-005941-e4fvj54l	351	8	unknown	unknown	JJ
cord-005941-e4fvj54l	351	9	origin	origin	NN
cord-005941-e4fvj54l	351	10	which	which	WDT
cord-005941-e4fvj54l	351	11	frequently	frequently	RB
cord-005941-e4fvj54l	351	12	involves	involve	VBZ
cord-005941-e4fvj54l	351	13	the	the	DT
cord-005941-e4fvj54l	351	14	lung	lung	NN
cord-005941-e4fvj54l	351	15	.	.	.
cord-005941-e4fvj54l	352	1	In	in	IN
cord-005941-e4fvj54l	352	2	3	3	CD
cord-005941-e4fvj54l	352	3	patients	patient	NNS
cord-005941-e4fvj54l	352	4	,	,	,
cord-005941-e4fvj54l	352	5	total	total	JJ
cord-005941-e4fvj54l	352	6	phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	352	7	in	in	IN
cord-005941-e4fvj54l	352	8	BAL	BAL	NNP
cord-005941-e4fvj54l	352	9	were	be	VBD
cord-005941-e4fvj54l	352	10	not	not	RB
cord-005941-e4fvj54l	352	11	significantly	significantly	RB
cord-005941-e4fvj54l	352	12	decreased	decrease	VBN
cord-005941-e4fvj54l	352	13	,	,	,
cord-005941-e4fvj54l	352	14	and	and	CC
cord-005941-e4fvj54l	352	15	changes	change	NNS
cord-005941-e4fvj54l	352	16	in	in	IN
cord-005941-e4fvj54l	352	17	phospholipid	phospholipid	NN
cord-005941-e4fvj54l	352	18	composition	composition	NN
cord-005941-e4fvj54l	352	19	were	be	VBD
cord-005941-e4fvj54l	352	20	not	not	RB
cord-005941-e4fvj54l	352	21	found	find	VBN
cord-005941-e4fvj54l	352	22	[	[	-LRB-
cord-005941-e4fvj54l	352	23	76	76	CD
cord-005941-e4fvj54l	352	24	]	]	-RRB-
cord-005941-e4fvj54l	352	25	.	.	.
cord-005941-e4fvj54l	353	1	In	in	IN
cord-005941-e4fvj54l	353	2	partial	partial	JJ
cord-005941-e4fvj54l	353	3	agreement	agreement	NN
cord-005941-e4fvj54l	353	4	with	with	IN
cord-005941-e4fvj54l	353	5	these	these	DT
cord-005941-e4fvj54l	353	6	observations	observation	NNS
cord-005941-e4fvj54l	353	7	,	,	,
cord-005941-e4fvj54l	353	8	no	no	DT
cord-005941-e4fvj54l	353	9	significant	significant	JJ
cord-005941-e4fvj54l	353	10	changes	change	NNS
cord-005941-e4fvj54l	353	11	in	in	IN
cord-005941-e4fvj54l	353	12	total	total	JJ
cord-005941-e4fvj54l	353	13	BAL	bal	NN
cord-005941-e4fvj54l	353	14	phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	353	15	were	be	VBD
cord-005941-e4fvj54l	353	16	found	find	VBN
cord-005941-e4fvj54l	353	17	in	in	IN
cord-005941-e4fvj54l	353	18	12	12	CD
cord-005941-e4fvj54l	353	19	untreated	untreated	JJ
cord-005941-e4fvj54l	353	20	patients	patient	NNS
cord-005941-e4fvj54l	353	21	with	with	IN
cord-005941-e4fvj54l	353	22	sarcoidosis	sarcoidosi	NNS
cord-005941-e4fvj54l	353	23	[	[	-LRB-
cord-005941-e4fvj54l	353	24	154	154	CD
cord-005941-e4fvj54l	353	25	]	]	-RRB-
cord-005941-e4fvj54l	353	26	,	,	,
cord-005941-e4fvj54l	353	27	but	but	CC
cord-005941-e4fvj54l	353	28	there	there	EX
cord-005941-e4fvj54l	353	29	was	be	VBD
cord-005941-e4fvj54l	353	30	an	an	DT
cord-005941-e4fvj54l	353	31	increase	increase	NN
cord-005941-e4fvj54l	353	32	in	in	IN
cord-005941-e4fvj54l	353	33	the	the	DT
cord-005941-e4fvj54l	353	34	PG	pg	NN
cord-005941-e4fvj54l	353	35	:	:	:
cord-005941-e4fvj54l	353	36	PI	pi	NN
cord-005941-e4fvj54l	353	37	ratio	ratio	NN
cord-005941-e4fvj54l	353	38	.	.	.
cord-005941-e4fvj54l	354	1	If	if	IN
cord-005941-e4fvj54l	354	2	confirmed	confirm	VBN
cord-005941-e4fvj54l	354	3	,	,	,
cord-005941-e4fvj54l	354	4	these	these	DT
cord-005941-e4fvj54l	354	5	findings	finding	NNS
cord-005941-e4fvj54l	354	6	could	could	MD
cord-005941-e4fvj54l	354	7	be	be	VB
cord-005941-e4fvj54l	354	8	of	of	IN
cord-005941-e4fvj54l	354	9	interest	interest	NN
cord-005941-e4fvj54l	354	10	as	as	IN
cord-005941-e4fvj54l	354	11	a	a	DT
cord-005941-e4fvj54l	354	12	clinical	clinical	JJ
cord-005941-e4fvj54l	354	13	tool	tool	NN
cord-005941-e4fvj54l	354	14	to	to	TO
cord-005941-e4fvj54l	354	15	separate	separate	VB
cord-005941-e4fvj54l	354	16	sarcoidosis	sarcoidosis	NN
cord-005941-e4fvj54l	354	17	from	from	IN
cord-005941-e4fvj54l	354	18	IPF	IPF	NNP
cord-005941-e4fvj54l	354	19	in	in	IN
cord-005941-e4fvj54l	354	20	the	the	DT
cord-005941-e4fvj54l	354	21	differential	differential	JJ
cord-005941-e4fvj54l	354	22	diagnosis	diagnosis	NN
cord-005941-e4fvj54l	354	23	of	of	IN
cord-005941-e4fvj54l	354	24	fibrosing	fibrose	VBG
cord-005941-e4fvj54l	354	25	lung	lung	NN
cord-005941-e4fvj54l	354	26	diseases	disease	NNS
cord-005941-e4fvj54l	354	27	.	.	.
cord-005941-e4fvj54l	355	1	Another	another	DT
cord-005941-e4fvj54l	355	2	study	study	NN
cord-005941-e4fvj54l	355	3	of	of	IN
cord-005941-e4fvj54l	355	4	13	13	CD
cord-005941-e4fvj54l	355	5	untreated	untreated	JJ
cord-005941-e4fvj54l	355	6	patients	patient	NNS
cord-005941-e4fvj54l	355	7	described	describe	VBD
cord-005941-e4fvj54l	355	8	a	a	DT
cord-005941-e4fvj54l	355	9	decrease	decrease	NN
cord-005941-e4fvj54l	355	10	of	of	IN
cord-005941-e4fvj54l	355	11	DPPC	DPPC	NNP
cord-005941-e4fvj54l	355	12	in	in	IN
cord-005941-e4fvj54l	355	13	BAL	BAL	NNP
cord-005941-e4fvj54l	355	14	[	[	-LRB-
cord-005941-e4fvj54l	355	15	12	12	CD
cord-005941-e4fvj54l	355	16	]	]	-RRB-
cord-005941-e4fvj54l	355	17	.	.	.
cord-005941-e4fvj54l	356	1	In	in	IN
cord-005941-e4fvj54l	356	2	8	8	CD
cord-005941-e4fvj54l	356	3	untreated	untreated	JJ
cord-005941-e4fvj54l	356	4	patients	patient	NNS
cord-005941-e4fvj54l	356	5	with	with	IN
cord-005941-e4fvj54l	356	6	active	active	JJ
cord-005941-e4fvj54l	356	7	sarcoidosis	sarcoidosis	NN
cord-005941-e4fvj54l	356	8	,	,	,
cord-005941-e4fvj54l	356	9	our	-PRON-	PRP$
cord-005941-e4fvj54l	356	10	group	group	NN
cord-005941-e4fvj54l	356	11	found	find	VBD
cord-005941-e4fvj54l	356	12	raised	raise	VBN
cord-005941-e4fvj54l	356	13	SP	SP	NNP
cord-005941-e4fvj54l	356	14	-	-	HYPH
cord-005941-e4fvj54l	356	15	A	A	NNP
cord-005941-e4fvj54l	356	16	levels	level	NNS
cord-005941-e4fvj54l	356	17	in	in	IN
cord-005941-e4fvj54l	356	18	BAL	bal	NN
cord-005941-e4fvj54l	356	19	in	in	IN
cord-005941-e4fvj54l	356	20	comparison	comparison	NN
cord-005941-e4fvj54l	356	21	with	with	IN
cord-005941-e4fvj54l	356	22	healthy	healthy	JJ
cord-005941-e4fvj54l	356	23	controls	control	NNS
cord-005941-e4fvj54l	356	24	[	[	-LRB-
cord-005941-e4fvj54l	356	25	63	63	CD
cord-005941-e4fvj54l	356	26	]	]	-RRB-
cord-005941-e4fvj54l	356	27	.	.	.
cord-005941-e4fvj54l	357	1	Further	further	JJ
cord-005941-e4fvj54l	357	2	studies	study	NNS
cord-005941-e4fvj54l	357	3	are	be	VBP
cord-005941-e4fvj54l	357	4	necessary	necessary	JJ
cord-005941-e4fvj54l	357	5	to	to	TO
cord-005941-e4fvj54l	357	6	confirm	confirm	VB
cord-005941-e4fvj54l	357	7	surfactant	surfactant	NN
cord-005941-e4fvj54l	357	8	changes	change	NNS
cord-005941-e4fvj54l	357	9	in	in	IN
cord-005941-e4fvj54l	357	10	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	357	11	sarcoidosis	sarcoidosis	NN
cord-005941-e4fvj54l	357	12	and	and	CC
cord-005941-e4fvj54l	357	13	to	to	TO
cord-005941-e4fvj54l	357	14	evaluate	evaluate	VB
cord-005941-e4fvj54l	357	15	their	-PRON-	PRP$
cord-005941-e4fvj54l	357	16	role	role	NN
cord-005941-e4fvj54l	357	17	in	in	IN
cord-005941-e4fvj54l	357	18	this	this	DT
cord-005941-e4fvj54l	357	19	disease	disease	NN
cord-005941-e4fvj54l	357	20	and	and	CC
cord-005941-e4fvj54l	357	21	their	-PRON-	PRP$
cord-005941-e4fvj54l	357	22	potential	potential	NN
cord-005941-e4fvj54l	357	23	in	in	IN
cord-005941-e4fvj54l	357	24	the	the	DT
cord-005941-e4fvj54l	357	25	differential	differential	JJ
cord-005941-e4fvj54l	357	26	diagnosis	diagnosis	NN
cord-005941-e4fvj54l	357	27	of	of	IN
cord-005941-e4fvj54l	357	28	fibrosing	fibrose	VBG
cord-005941-e4fvj54l	357	29	lung	lung	NN
cord-005941-e4fvj54l	357	30	disorders	disorder	NNS
cord-005941-e4fvj54l	357	31	.	.	.
cord-005941-e4fvj54l	358	1	The	the	DT
cord-005941-e4fvj54l	358	2	known	know	VBN
cord-005941-e4fvj54l	358	3	immunoregulatory	immunoregulatory	JJ
cord-005941-e4fvj54l	358	4	role	role	NN
cord-005941-e4fvj54l	358	5	of	of	IN
cord-005941-e4fvj54l	358	6	surfactant	surfactant	NN
cord-005941-e4fvj54l	358	7	makes	make	VBZ
cord-005941-e4fvj54l	358	8	this	this	DT
cord-005941-e4fvj54l	358	9	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	358	10	disease	disease	NN
cord-005941-e4fvj54l	358	11	an	an	DT
cord-005941-e4fvj54l	358	12	interesting	interesting	JJ
cord-005941-e4fvj54l	358	13	object	object	NN
cord-005941-e4fvj54l	358	14	of	of	IN
cord-005941-e4fvj54l	358	15	surfactant	surfactant	NN
cord-005941-e4fvj54l	358	16	studies	study	NNS
cord-005941-e4fvj54l	358	17	.	.	.
cord-005941-e4fvj54l	359	1	However	however	RB
cord-005941-e4fvj54l	359	2	,	,	,
cord-005941-e4fvj54l	359	3	only	only	RB
cord-005941-e4fvj54l	359	4	a	a	DT
cord-005941-e4fvj54l	359	5	few	few	JJ
cord-005941-e4fvj54l	359	6	reports	report	NNS
cord-005941-e4fvj54l	359	7	have	have	VBP
cord-005941-e4fvj54l	359	8	so	so	RB
cord-005941-e4fvj54l	359	9	far	far	RB
cord-005941-e4fvj54l	359	10	addressed	address	VBN
cord-005941-e4fvj54l	359	11	the	the	DT
cord-005941-e4fvj54l	359	12	role	role	NN
cord-005941-e4fvj54l	359	13	of	of	IN
cord-005941-e4fvj54l	359	14	surfactant	surfactant	NN
cord-005941-e4fvj54l	359	15	in	in	IN
cord-005941-e4fvj54l	359	16	hypersensitivity	hypersensitivity	NN
cord-005941-e4fvj54l	359	17	pneumonitis	pneumonitis	NN
cord-005941-e4fvj54l	359	18	(	(	-LRB-
cord-005941-e4fvj54l	359	19	HP	HP	NNP
cord-005941-e4fvj54l	359	20	)	)	-RRB-
cord-005941-e4fvj54l	359	21	.	.	.
cord-005941-e4fvj54l	360	1	In	in	IN
cord-005941-e4fvj54l	360	2	a	a	DT
cord-005941-e4fvj54l	360	3	recent	recent	JJ
cord-005941-e4fvj54l	360	4	study	study	NN
cord-005941-e4fvj54l	360	5	,	,	,
cord-005941-e4fvj54l	360	6	3	3	CD
cord-005941-e4fvj54l	360	7	untreated	untreated	JJ
cord-005941-e4fvj54l	360	8	patients	patient	NNS
cord-005941-e4fvj54l	360	9	with	with	IN
cord-005941-e4fvj54l	360	10	HP	HP	NNP
cord-005941-e4fvj54l	360	11	are	be	VBP
cord-005941-e4fvj54l	360	12	mentioned	mention	VBN
cord-005941-e4fvj54l	360	13	whose	whose	WP$
cord-005941-e4fvj54l	360	14	SP	SP	NNP
cord-005941-e4fvj54l	360	15	-	-	HYPH
cord-005941-e4fvj54l	360	16	A	a	DT
cord-005941-e4fvj54l	360	17	values	value	NNS
cord-005941-e4fvj54l	360	18	in	in	IN
cord-005941-e4fvj54l	360	19	BAL	BAL	NNP
cord-005941-e4fvj54l	360	20	were	be	VBD
cord-005941-e4fvj54l	360	21	lower	low	JJR
cord-005941-e4fvj54l	360	22	than	than	IN
cord-005941-e4fvj54l	360	23	in	in	IN
cord-005941-e4fvj54l	360	24	normal	normal	JJ
cord-005941-e4fvj54l	360	25	subjects	subject	NNS
cord-005941-e4fvj54l	360	26	[	[	-LRB-
cord-005941-e4fvj54l	360	27	116	116	CD
cord-005941-e4fvj54l	360	28	]	]	-RRB-
cord-005941-e4fvj54l	360	29	.	.	.
cord-005941-e4fvj54l	361	1	By	by	IN
cord-005941-e4fvj54l	361	2	contrast	contrast	NN
cord-005941-e4fvj54l	361	3	,	,	,
cord-005941-e4fvj54l	361	4	our	-PRON-	PRP$
cord-005941-e4fvj54l	361	5	own	own	JJ
cord-005941-e4fvj54l	361	6	preliminary	preliminary	JJ
cord-005941-e4fvj54l	361	7	data	datum	NNS
cord-005941-e4fvj54l	361	8	from	from	IN
cord-005941-e4fvj54l	361	9	BAL	bal	NN
cord-005941-e4fvj54l	361	10	fluids	fluid	NNS
cord-005941-e4fvj54l	361	11	of	of	IN
cord-005941-e4fvj54l	361	12	8	8	CD
cord-005941-e4fvj54l	361	13	patients	patient	NNS
cord-005941-e4fvj54l	361	14	with	with	IN
cord-005941-e4fvj54l	361	15	untreated	untreated	JJ
cord-005941-e4fvj54l	361	16	,	,	,
cord-005941-e4fvj54l	361	17	active	active	JJ
cord-005941-e4fvj54l	361	18	HP	HP	NNP
cord-005941-e4fvj54l	361	19	show	show	VBP
cord-005941-e4fvj54l	361	20	higher	high	JJR
cord-005941-e4fvj54l	361	21	SP	SP	NNP
cord-005941-e4fvj54l	361	22	-	-	HYPH
cord-005941-e4fvj54l	361	23	A	a	DT
cord-005941-e4fvj54l	361	24	values	value	NNS
cord-005941-e4fvj54l	361	25	than	than	IN
cord-005941-e4fvj54l	361	26	controls	control	NNS
cord-005941-e4fvj54l	361	27	[	[	-LRB-
cord-005941-e4fvj54l	361	28	63	63	CD
cord-005941-e4fvj54l	361	29	]	]	-RRB-
cord-005941-e4fvj54l	361	30	.	.	.
cord-005941-e4fvj54l	362	1	Also	also	RB
cord-005941-e4fvj54l	362	2	,	,	,
cord-005941-e4fvj54l	362	3	the	the	DT
cord-005941-e4fvj54l	362	4	SP	SP	NNP
cord-005941-e4fvj54l	362	5	-	-	HYPH
cord-005941-e4fvj54l	362	6	A	A	NNP
cord-005941-e4fvj54l	362	7	content	content	NN
cord-005941-e4fvj54l	362	8	of	of	IN
cord-005941-e4fvj54l	362	9	alveolar	alveolar	JJ
cord-005941-e4fvj54l	362	10	macrophages	macrophage	NNS
cord-005941-e4fvj54l	362	11	(	(	-LRB-
cord-005941-e4fvj54l	362	12	obtained	obtain	VBN
cord-005941-e4fvj54l	362	13	by	by	IN
cord-005941-e4fvj54l	362	14	BAL	BAL	NNP
cord-005941-e4fvj54l	362	15	)	)	-RRB-
cord-005941-e4fvj54l	362	16	as	as	IN
cord-005941-e4fvj54l	362	17	assessed	assess	VBN
cord-005941-e4fvj54l	362	18	by	by	IN
cord-005941-e4fvj54l	362	19	immunocytochemistry	immunocytochemistry	NNP
cord-005941-e4fvj54l	362	20	was	be	VBD
cord-005941-e4fvj54l	362	21	elevated	elevate	VBN
cord-005941-e4fvj54l	362	22	in	in	IN
cord-005941-e4fvj54l	362	23	untreated	untreated	JJ
cord-005941-e4fvj54l	362	24	HP	HP	NNP
cord-005941-e4fvj54l	362	25	patients	patient	NNS
cord-005941-e4fvj54l	362	26	in	in	IN
cord-005941-e4fvj54l	362	27	comparison	comparison	NN
cord-005941-e4fvj54l	362	28	with	with	IN
cord-005941-e4fvj54l	362	29	healthy	healthy	JJ
cord-005941-e4fvj54l	362	30	controls	control	NNS
cord-005941-e4fvj54l	362	31	[	[	-LRB-
cord-005941-e4fvj54l	362	32	54	54	CD
cord-005941-e4fvj54l	362	33	]	]	-RRB-
cord-005941-e4fvj54l	362	34	.	.	.
cord-005941-e4fvj54l	363	1	Another	another	DT
cord-005941-e4fvj54l	363	2	recent	recent	JJ
cord-005941-e4fvj54l	363	3	study	study	NN
cord-005941-e4fvj54l	363	4	demonstrated	demonstrate	VBD
cord-005941-e4fvj54l	363	5	that	that	IN
cord-005941-e4fvj54l	363	6	acute	acute	JJ
cord-005941-e4fvj54l	363	7	immune	immune	JJ
cord-005941-e4fvj54l	363	8	lung	lung	NN
cord-005941-e4fvj54l	363	9	injury	injury	NN
cord-005941-e4fvj54l	363	10	in	in	IN
cord-005941-e4fvj54l	363	11	guinea	guinea	NN
cord-005941-e4fvj54l	363	12	pigs	pig	NNS
cord-005941-e4fvj54l	363	13	is	be	VBZ
cord-005941-e4fvj54l	363	14	augmented	augment	VBN
cord-005941-e4fvj54l	363	15	in	in	IN
cord-005941-e4fvj54l	363	16	animals	animal	NNS
cord-005941-e4fvj54l	363	17	with	with	IN
cord-005941-e4fvj54l	363	18	partial	partial	JJ
cord-005941-e4fvj54l	363	19	surfactant	surfactant	NN
cord-005941-e4fvj54l	363	20	depletion	depletion	NN
cord-005941-e4fvj54l	363	21	while	while	IN
cord-005941-e4fvj54l	363	22	surfactant	surfactant	NN
cord-005941-e4fvj54l	363	23	replacement	replacement	NN
cord-005941-e4fvj54l	363	24	ameliorated	ameliorate	VBD
cord-005941-e4fvj54l	363	25	the	the	DT
cord-005941-e4fvj54l	363	26	parameters	parameter	NNS
cord-005941-e4fvj54l	363	27	of	of	IN
cord-005941-e4fvj54l	363	28	lung	lung	NN
cord-005941-e4fvj54l	363	29	injury	injury	NN
cord-005941-e4fvj54l	363	30	[	[	-LRB-
cord-005941-e4fvj54l	363	31	153	153	CD
cord-005941-e4fvj54l	363	32	]	]	-RRB-
cord-005941-e4fvj54l	363	33	.	.	.
cord-005941-e4fvj54l	364	1	This	this	DT
cord-005941-e4fvj54l	364	2	prompted	prompt	VBD
cord-005941-e4fvj54l	364	3	a	a	DT
cord-005941-e4fvj54l	364	4	somewhat	somewhat	RB
cord-005941-e4fvj54l	364	5	optimistic	optimistic	JJ
cord-005941-e4fvj54l	364	6	comment	comment	NN
cord-005941-e4fvj54l	364	7	that	that	IN
cord-005941-e4fvj54l	364	8	surfactant	surfactant	NN
cord-005941-e4fvj54l	364	9	replacement	replacement	NN
cord-005941-e4fvj54l	364	10	might	may	MD
cord-005941-e4fvj54l	364	11	be	be	VB
cord-005941-e4fvj54l	364	12	useful	useful	JJ
cord-005941-e4fvj54l	364	13	in	in	IN
cord-005941-e4fvj54l	364	14	the	the	DT
cord-005941-e4fvj54l	364	15	therapy	therapy	NN
cord-005941-e4fvj54l	364	16	of	of	IN
cord-005941-e4fvj54l	364	17	cell	cell	NN
cord-005941-e4fvj54l	364	18	-	-	HYPH
cord-005941-e4fvj54l	364	19	mediated	mediate	VBN
cord-005941-e4fvj54l	364	20	immune	immune	JJ
cord-005941-e4fvj54l	364	21	diseases	disease	NNS
cord-005941-e4fvj54l	364	22	of	of	IN
cord-005941-e4fvj54l	364	23	the	the	DT
cord-005941-e4fvj54l	364	24	lung	lung	NN
cord-005941-e4fvj54l	364	25	[	[	-LRB-
cord-005941-e4fvj54l	364	26	151	151	CD
cord-005941-e4fvj54l	364	27	]	]	-RRB-
cord-005941-e4fvj54l	364	28	.	.	.
cord-005941-e4fvj54l	365	1	It	-PRON-	PRP
cord-005941-e4fvj54l	365	2	is	be	VBZ
cord-005941-e4fvj54l	365	3	an	an	DT
cord-005941-e4fvj54l	365	4	attractive	attractive	JJ
cord-005941-e4fvj54l	365	5	hypothesis	hypothesis	NN
cord-005941-e4fvj54l	365	6	that	that	IN
cord-005941-e4fvj54l	365	7	surfactant	surfactant	NN
cord-005941-e4fvj54l	365	8	abnormalities	abnormality	NNS
cord-005941-e4fvj54l	365	9	may	may	MD
cord-005941-e4fvj54l	365	10	play	play	VB
cord-005941-e4fvj54l	365	11	a	a	DT
cord-005941-e4fvj54l	365	12	role	role	NN
cord-005941-e4fvj54l	365	13	in	in	IN
cord-005941-e4fvj54l	365	14	the	the	DT
cord-005941-e4fvj54l	365	15	pathogenesis	pathogenesis	NN
cord-005941-e4fvj54l	365	16	of	of	IN
cord-005941-e4fvj54l	365	17	pneumonia	pneumonia	NN
cord-005941-e4fvj54l	366	1	and/or	and/or	CC
cord-005941-e4fvj54l	366	2	that	that	DT
cord-005941-e4fvj54l	366	3	surfactant	surfactant	NN
cord-005941-e4fvj54l	366	4	changes	change	NNS
cord-005941-e4fvj54l	366	5	occur	occur	VBP
cord-005941-e4fvj54l	366	6	as	as	IN
cord-005941-e4fvj54l	366	7	a	a	DT
cord-005941-e4fvj54l	366	8	consequence	consequence	NN
cord-005941-e4fvj54l	366	9	of	of	IN
cord-005941-e4fvj54l	366	10	alveolar	alveolar	JJ
cord-005941-e4fvj54l	366	11	infection	infection	NN
cord-005941-e4fvj54l	366	12	.	.	.
cord-005941-e4fvj54l	367	1	As	as	IN
cord-005941-e4fvj54l	367	2	an	an	DT
cord-005941-e4fvj54l	367	3	example	example	NN
cord-005941-e4fvj54l	367	4	,	,	,
cord-005941-e4fvj54l	367	5	viral	viral	JJ
cord-005941-e4fvj54l	367	6	infection	infection	NN
cord-005941-e4fvj54l	367	7	could	could	MD
cord-005941-e4fvj54l	367	8	damage	damage	VB
cord-005941-e4fvj54l	367	9	alveolar	alveolar	NN
cord-005941-e4fvj54l	367	10	surfacrant	surfacrant	NNP
cord-005941-e4fvj54l	367	11	,	,	,
cord-005941-e4fvj54l	367	12	facilitating	facilitate	VBG
cord-005941-e4fvj54l	367	13	the	the	DT
cord-005941-e4fvj54l	367	14	secondary	secondary	JJ
cord-005941-e4fvj54l	367	15	invasion	invasion	NN
cord-005941-e4fvj54l	367	16	of	of	IN
cord-005941-e4fvj54l	367	17	bacteria	bacteria	NNS
cord-005941-e4fvj54l	367	18	.	.	.
cord-005941-e4fvj54l	368	1	As	as	IN
cord-005941-e4fvj54l	368	2	yet	yet	RB
cord-005941-e4fvj54l	368	3	,	,	,
cord-005941-e4fvj54l	368	4	only	only	RB
cord-005941-e4fvj54l	368	5	a	a	DT
cord-005941-e4fvj54l	368	6	few	few	JJ
cord-005941-e4fvj54l	368	7	studies	study	NNS
cord-005941-e4fvj54l	368	8	have	have	VBP
cord-005941-e4fvj54l	368	9	investigated	investigate	VBN
cord-005941-e4fvj54l	368	10	these	these	DT
cord-005941-e4fvj54l	368	11	questions	question	NNS
cord-005941-e4fvj54l	368	12	,	,	,
cord-005941-e4fvj54l	368	13	so	so	IN
cord-005941-e4fvj54l	368	14	that	that	IN
cord-005941-e4fvj54l	368	15	our	-PRON-	PRP$
cord-005941-e4fvj54l	368	16	knowledge	knowledge	NN
cord-005941-e4fvj54l	368	17	of	of	IN
cord-005941-e4fvj54l	368	18	the	the	DT
cord-005941-e4fvj54l	368	19	role	role	NN
cord-005941-e4fvj54l	368	20	of	of	IN
cord-005941-e4fvj54l	368	21	surfactant	surfactant	NN
cord-005941-e4fvj54l	368	22	in	in	IN
cord-005941-e4fvj54l	368	23	pneumonia	pneumonia	NN
cord-005941-e4fvj54l	368	24	is	be	VBZ
cord-005941-e4fvj54l	368	25	still	still	RB
cord-005941-e4fvj54l	368	26	rather	rather	RB
cord-005941-e4fvj54l	368	27	incomplete	incomplete	JJ
cord-005941-e4fvj54l	368	28	.	.	.
cord-005941-e4fvj54l	369	1	In	in	IN
cord-005941-e4fvj54l	369	2	patients	patient	NNS
cord-005941-e4fvj54l	369	3	with	with	IN
cord-005941-e4fvj54l	369	4	bacterial	bacterial	JJ
cord-005941-e4fvj54l	369	5	pneumonia	pneumonia	NN
cord-005941-e4fvj54l	369	6	,	,	,
cord-005941-e4fvj54l	369	7	changes	change	NNS
cord-005941-e4fvj54l	369	8	in	in	IN
cord-005941-e4fvj54l	369	9	the	the	DT
cord-005941-e4fvj54l	369	10	fatty	fatty	JJ
cord-005941-e4fvj54l	369	11	acid	acid	NN
cord-005941-e4fvj54l	369	12	composition	composition	NN
cord-005941-e4fvj54l	369	13	of	of	IN
cord-005941-e4fvj54l	369	14	BAL	bal	NN
cord-005941-e4fvj54l	369	15	phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	369	16	have	have	VBP
cord-005941-e4fvj54l	369	17	been	be	VBN
cord-005941-e4fvj54l	369	18	described	describe	VBN
cord-005941-e4fvj54l	369	19	[	[	-LRB-
cord-005941-e4fvj54l	369	20	11	11	CD
cord-005941-e4fvj54l	369	21	]	]	-RRB-
cord-005941-e4fvj54l	369	22	.	.	.
cord-005941-e4fvj54l	370	1	In	in	IN
cord-005941-e4fvj54l	370	2	an	an	DT
cord-005941-e4fvj54l	370	3	animal	animal	NN
cord-005941-e4fvj54l	370	4	model	model	NN
cord-005941-e4fvj54l	370	5	of	of	IN
cord-005941-e4fvj54l	370	6	Pneumocystis	Pneumocystis	NNP
cord-005941-e4fvj54l	370	7	carinii	carinii	FW
cord-005941-e4fvj54l	370	8	pneumonia	pneumonia	NN
cord-005941-e4fvj54l	370	9	,	,	,
cord-005941-e4fvj54l	370	10	increased	increase	VBD
cord-005941-e4fvj54l	371	1	amounts	amount	NNS
cord-005941-e4fvj54l	371	2	of	of	IN
cord-005941-e4fvj54l	371	3	total	total	JJ
cord-005941-e4fvj54l	371	4	phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	371	5	and	and	CC
cord-005941-e4fvj54l	371	6	decreases	decrease	NNS
cord-005941-e4fvj54l	371	7	in	in	IN
cord-005941-e4fvj54l	371	8	the	the	DT
cord-005941-e4fvj54l	371	9	percentage	percentage	NN
cord-005941-e4fvj54l	371	10	of	of	IN
cord-005941-e4fvj54l	371	11	PC	pc	NN
cord-005941-e4fvj54l	371	12	were	be	VBD
cord-005941-e4fvj54l	371	13	observed	observe	VBN
cord-005941-e4fvj54l	371	14	[	[	-LRB-
cord-005941-e4fvj54l	371	15	162	162	CD
cord-005941-e4fvj54l	371	16	]	]	-RRB-
cord-005941-e4fvj54l	371	17	.	.	.
cord-005941-e4fvj54l	372	1	It	-PRON-	PRP
cord-005941-e4fvj54l	372	2	was	be	VBD
cord-005941-e4fvj54l	372	3	hypothesized	hypothesize	VBN
cord-005941-e4fvj54l	372	4	that	that	IN
cord-005941-e4fvj54l	372	5	these	these	DT
cord-005941-e4fvj54l	372	6	findings	finding	NNS
cord-005941-e4fvj54l	372	7	contribute	contribute	VBP
cord-005941-e4fvj54l	372	8	to	to	IN
cord-005941-e4fvj54l	372	9	the	the	DT
cord-005941-e4fvj54l	372	10	altered	altered	JJ
cord-005941-e4fvj54l	372	11	lung	lung	NN
cord-005941-e4fvj54l	372	12	mechanics	mechanic	NNS
cord-005941-e4fvj54l	372	13	and	and	CC
cord-005941-e4fvj54l	372	14	respiratory	respiratory	JJ
cord-005941-e4fvj54l	372	15	distress	distress	NN
cord-005941-e4fvj54l	372	16	in	in	IN
cord-005941-e4fvj54l	372	17	this	this	DT
cord-005941-e4fvj54l	372	18	disease	disease	NN
cord-005941-e4fvj54l	372	19	.	.	.
cord-005941-e4fvj54l	373	1	However	however	RB
cord-005941-e4fvj54l	373	2	,	,	,
cord-005941-e4fvj54l	373	3	it	-PRON-	PRP
cord-005941-e4fvj54l	373	4	should	should	MD
cord-005941-e4fvj54l	373	5	be	be	VB
cord-005941-e4fvj54l	373	6	stressed	stress	VBN
cord-005941-e4fvj54l	373	7	once	once	RB
cord-005941-e4fvj54l	373	8	more	more	JJR
cord-005941-e4fvj54l	373	9	that	that	IN
cord-005941-e4fvj54l	373	10	phospholipid	phospholipid	NN
cord-005941-e4fvj54l	373	11	changes	change	NNS
cord-005941-e4fvj54l	373	12	may	may	MD
cord-005941-e4fvj54l	373	13	not	not	RB
cord-005941-e4fvj54l	373	14	necessarily	necessarily	RB
cord-005941-e4fvj54l	373	15	reflect	reflect	VB
cord-005941-e4fvj54l	373	16	true	true	JJ
cord-005941-e4fvj54l	373	17	surfactant	surfactant	NN
cord-005941-e4fvj54l	373	18	abnormalities	abnormality	NNS
cord-005941-e4fvj54l	373	19	.	.	.
cord-005941-e4fvj54l	374	1	In	in	IN
cord-005941-e4fvj54l	374	2	22	22	CD
cord-005941-e4fvj54l	374	3	patients	patient	NNS
cord-005941-e4fvj54l	374	4	with	with	IN
cord-005941-e4fvj54l	374	5	acquired	acquire	VBN
cord-005941-e4fvj54l	374	6	immunodeficiency	immunodeficiency	NNP
cord-005941-e4fvj54l	374	7	syndrome	syndrome	NN
cord-005941-e4fvj54l	374	8	(	(	-LRB-
cord-005941-e4fvj54l	374	9	AIDS)-related	AIDS)-related	NNP
cord-005941-e4fvj54l	374	10	pneumonia	pneumonia	NN
cord-005941-e4fvj54l	374	11	(	(	-LRB-
cord-005941-e4fvj54l	374	12	mostly	mostly	RB
cord-005941-e4fvj54l	374	13	P.	P.	NNP
cord-005941-e4fvj54l	374	14	carinii	carinii	FW
cord-005941-e4fvj54l	374	15	pneumonia	pneumonia	NN
cord-005941-e4fvj54l	374	16	)	)	-RRB-
cord-005941-e4fvj54l	374	17	,	,	,
cord-005941-e4fvj54l	374	18	a	a	DT
cord-005941-e4fvj54l	374	19	marked	marked	JJ
cord-005941-e4fvj54l	374	20	increase	increase	NN
cord-005941-e4fvj54l	374	21	of	of	IN
cord-005941-e4fvj54l	374	22	SP	SP	NNP
cord-005941-e4fvj54l	374	23	-	-	HYPH
cord-005941-e4fvj54l	374	24	A	A	NNP
cord-005941-e4fvj54l	374	25	in	in	IN
cord-005941-e4fvj54l	374	26	BAL	BAL	NNP
cord-005941-e4fvj54l	374	27	was	be	VBD
cord-005941-e4fvj54l	374	28	reported	report	VBN
cord-005941-e4fvj54l	374	29	in	in	IN
cord-005941-e4fvj54l	374	30	comparison	comparison	NN
cord-005941-e4fvj54l	374	31	with	with	IN
cord-005941-e4fvj54l	374	32	21	21	CD
cord-005941-e4fvj54l	374	33	healthy	healthy	JJ
cord-005941-e4fvj54l	374	34	controls	control	NNS
cord-005941-e4fvj54l	374	35	[	[	-LRB-
cord-005941-e4fvj54l	374	36	142	142	CD
cord-005941-e4fvj54l	374	37	]	]	-RRB-
cord-005941-e4fvj54l	374	38	.	.	.
cord-005941-e4fvj54l	375	1	Phospholipid	phospholipid	NN
cord-005941-e4fvj54l	375	2	analysis	analysis	NN
cord-005941-e4fvj54l	375	3	was	be	VBD
cord-005941-e4fvj54l	375	4	not	not	RB
cord-005941-e4fvj54l	375	5	done	do	VBN
cord-005941-e4fvj54l	375	6	,	,	,
cord-005941-e4fvj54l	375	7	and	and	CC
cord-005941-e4fvj54l	375	8	it	-PRON-	PRP
cord-005941-e4fvj54l	375	9	remained	remain	VBD
cord-005941-e4fvj54l	375	10	unclear	unclear	JJ
cord-005941-e4fvj54l	375	11	whether	whether	IN
cord-005941-e4fvj54l	375	12	the	the	DT
cord-005941-e4fvj54l	375	13	observed	observed	JJ
cord-005941-e4fvj54l	375	14	changes	change	NNS
cord-005941-e4fvj54l	375	15	were	be	VBD
cord-005941-e4fvj54l	375	16	primarily	primarily	RB
cord-005941-e4fvj54l	375	17	related	relate	VBN
cord-005941-e4fvj54l	375	18	to	to	IN
cord-005941-e4fvj54l	375	19	human	human	JJ
cord-005941-e4fvj54l	375	20	immunodeficiency	immunodeficiency	NN
cord-005941-e4fvj54l	375	21	virus	virus	NN
cord-005941-e4fvj54l	375	22	(	(	-LRB-
cord-005941-e4fvj54l	375	23	HIV	HIV	NNP
cord-005941-e4fvj54l	375	24	)	)	-RRB-
cord-005941-e4fvj54l	375	25	infection	infection	NN
cord-005941-e4fvj54l	375	26	or	or	CC
cord-005941-e4fvj54l	375	27	to	to	IN
cord-005941-e4fvj54l	375	28	pneumonia	pneumonia	NN
cord-005941-e4fvj54l	375	29	.	.	.
cord-005941-e4fvj54l	376	1	Further	further	JJ
cord-005941-e4fvj54l	376	2	studies	study	NNS
cord-005941-e4fvj54l	376	3	of	of	IN
cord-005941-e4fvj54l	376	4	the	the	DT
cord-005941-e4fvj54l	376	5	reactions	reaction	NNS
cord-005941-e4fvj54l	376	6	and	and	CC
cord-005941-e4fvj54l	376	7	the	the	DT
cord-005941-e4fvj54l	376	8	potential	potential	JJ
cord-005941-e4fvj54l	376	9	role	role	NN
cord-005941-e4fvj54l	376	10	of	of	IN
cord-005941-e4fvj54l	376	11	the	the	DT
cord-005941-e4fvj54l	376	12	surfactant	surfactant	NN
cord-005941-e4fvj54l	376	13	system	system	NN
cord-005941-e4fvj54l	376	14	in	in	IN
cord-005941-e4fvj54l	376	15	bacterial	bacterial	JJ
cord-005941-e4fvj54l	376	16	or	or	CC
cord-005941-e4fvj54l	376	17	viral	viral	JJ
cord-005941-e4fvj54l	376	18	invasion	invasion	NN
cord-005941-e4fvj54l	376	19	of	of	IN
cord-005941-e4fvj54l	376	20	the	the	DT
cord-005941-e4fvj54l	376	21	alveolar	alveolar	JJ
cord-005941-e4fvj54l	376	22	space	space	NN
cord-005941-e4fvj54l	376	23	are	be	VBP
cord-005941-e4fvj54l	376	24	certainly	certainly	RB
cord-005941-e4fvj54l	376	25	necessary	necessary	JJ
cord-005941-e4fvj54l	376	26	and	and	CC
cord-005941-e4fvj54l	376	27	may	may	MD
cord-005941-e4fvj54l	376	28	be	be	VB
cord-005941-e4fvj54l	376	29	awaited	await	VBN
cord-005941-e4fvj54l	376	30	with	with	IN
cord-005941-e4fvj54l	376	31	interest	interest	NN
cord-005941-e4fvj54l	376	32	.	.	.
cord-005941-e4fvj54l	377	1	This	this	DT
cord-005941-e4fvj54l	377	2	is	be	VBZ
cord-005941-e4fvj54l	377	3	a	a	DT
cord-005941-e4fvj54l	377	4	rare	rare	JJ
cord-005941-e4fvj54l	377	5	disease	disease	NN
cord-005941-e4fvj54l	377	6	in	in	IN
cord-005941-e4fvj54l	377	7	which	which	WDT
cord-005941-e4fvj54l	377	8	for	for	IN
cord-005941-e4fvj54l	377	9	unknown	unknown	JJ
cord-005941-e4fvj54l	377	10	reasons	reason	NNS
cord-005941-e4fvj54l	377	11	the	the	DT
cord-005941-e4fvj54l	377	12	alveolar	alveolar	NN
cord-005941-e4fvj54l	377	13	type	type	NN
cord-005941-e4fvj54l	377	14	II	ii	CD
cord-005941-e4fvj54l	377	15	cell	cell	NN
cord-005941-e4fvj54l	377	16	synthesizes	synthesize	VBZ
cord-005941-e4fvj54l	377	17	and	and	CC
cord-005941-e4fvj54l	377	18	secretes	secrete	VBZ
cord-005941-e4fvj54l	377	19	excessive	excessive	JJ
cord-005941-e4fvj54l	377	20	amounts	amount	NNS
cord-005941-e4fvj54l	377	21	of	of	IN
cord-005941-e4fvj54l	377	22	abnormal	abnormal	JJ
cord-005941-e4fvj54l	377	23	surfactant	surfactant	NN
cord-005941-e4fvj54l	377	24	material	material	NN
cord-005941-e4fvj54l	377	25	.	.	.
cord-005941-e4fvj54l	378	1	Lungs	lung	NNS
cord-005941-e4fvj54l	378	2	of	of	IN
cord-005941-e4fvj54l	378	3	silica	silica	NN
cord-005941-e4fvj54l	378	4	-	-	HYPH
cord-005941-e4fvj54l	378	5	exposed	expose	VBN
cord-005941-e4fvj54l	378	6	animals	animal	NNS
cord-005941-e4fvj54l	378	7	share	share	VBP
cord-005941-e4fvj54l	378	8	common	common	JJ
cord-005941-e4fvj54l	378	9	features	feature	NNS
cord-005941-e4fvj54l	378	10	with	with	IN
cord-005941-e4fvj54l	378	11	human	human	JJ
cord-005941-e4fvj54l	378	12	alveolar	alveolar	NN
cord-005941-e4fvj54l	378	13	proteinosis	proteinosis	NN
cord-005941-e4fvj54l	378	14	(	(	-LRB-
cord-005941-e4fvj54l	378	15	see	see	VB
cord-005941-e4fvj54l	378	16	above	above	RB
cord-005941-e4fvj54l	378	17	)	)	-RRB-
cord-005941-e4fvj54l	378	18	,	,	,
cord-005941-e4fvj54l	378	19	but	but	CC
cord-005941-e4fvj54l	378	20	there	there	EX
cord-005941-e4fvj54l	378	21	is	be	VBZ
cord-005941-e4fvj54l	378	22	no	no	DT
cord-005941-e4fvj54l	378	23	evidence	evidence	NN
cord-005941-e4fvj54l	378	24	that	that	IN
cord-005941-e4fvj54l	378	25	dust	dust	NN
cord-005941-e4fvj54l	378	26	exposure	exposure	NN
cord-005941-e4fvj54l	378	27	has	have	VBZ
cord-005941-e4fvj54l	378	28	a	a	DT
cord-005941-e4fvj54l	378	29	role	role	NN
cord-005941-e4fvj54l	378	30	in	in	IN
cord-005941-e4fvj54l	378	31	the	the	DT
cord-005941-e4fvj54l	378	32	pathogenesis	pathogenesis	NN
cord-005941-e4fvj54l	378	33	of	of	IN
cord-005941-e4fvj54l	378	34	this	this	DT
cord-005941-e4fvj54l	378	35	disease	disease	NN
cord-005941-e4fvj54l	378	36	in	in	IN
cord-005941-e4fvj54l	378	37	man	man	NN
cord-005941-e4fvj54l	378	38	.	.	.
cord-005941-e4fvj54l	379	1	A	a	DT
cord-005941-e4fvj54l	379	2	typical	typical	JJ
cord-005941-e4fvj54l	379	3	finding	finding	NN
cord-005941-e4fvj54l	379	4	is	be	VBZ
cord-005941-e4fvj54l	379	5	the	the	DT
cord-005941-e4fvj54l	379	6	accumulation	accumulation	NN
cord-005941-e4fvj54l	379	7	of	of	IN
cord-005941-e4fvj54l	379	8	tubular	tubular	JJ
cord-005941-e4fvj54l	379	9	myelin	myelin	NN
cord-005941-e4fvj54l	379	10	-	-	HYPH
cord-005941-e4fvj54l	379	11	like	like	JJ
cord-005941-e4fvj54l	379	12	multilamellated	multilamellated	JJ
cord-005941-e4fvj54l	379	13	structures	structure	NNS
cord-005941-e4fvj54l	379	14	in	in	IN
cord-005941-e4fvj54l	379	15	the	the	DT
cord-005941-e4fvj54l	379	16	alveoli	alveolus	NNS
cord-005941-e4fvj54l	379	17	[	[	-LRB-
cord-005941-e4fvj54l	379	18	78	78	CD
cord-005941-e4fvj54l	379	19	]	]	-RRB-
cord-005941-e4fvj54l	379	20	.	.	.
cord-005941-e4fvj54l	380	1	The	the	DT
cord-005941-e4fvj54l	380	2	BAL	bal	NN
cord-005941-e4fvj54l	380	3	fluid	fluid	NN
cord-005941-e4fvj54l	380	4	is	be	VBZ
cord-005941-e4fvj54l	380	5	characterized	characterize	VBN
cord-005941-e4fvj54l	380	6	by	by	IN
cord-005941-e4fvj54l	380	7	increased	increase	VBN
cord-005941-e4fvj54l	380	8	content	content	NN
cord-005941-e4fvj54l	380	9	of	of	IN
cord-005941-e4fvj54l	380	10	total	total	JJ
cord-005941-e4fvj54l	380	11	phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	380	12	with	with	IN
cord-005941-e4fvj54l	380	13	a	a	DT
cord-005941-e4fvj54l	380	14	relative	relative	JJ
cord-005941-e4fvj54l	380	15	decrease	decrease	NN
cord-005941-e4fvj54l	380	16	in	in	IN
cord-005941-e4fvj54l	380	17	PG	PG	NNP
cord-005941-e4fvj54l	380	18	and	and	CC
cord-005941-e4fvj54l	380	19	an	an	DT
cord-005941-e4fvj54l	380	20	increase	increase	NN
cord-005941-e4fvj54l	380	21	in	in	IN
cord-005941-e4fvj54l	380	22	PI	PI	NNP
cord-005941-e4fvj54l	380	23	[	[	-LRB-
cord-005941-e4fvj54l	380	24	77	77	CD
cord-005941-e4fvj54l	380	25	]	]	-RRB-
cord-005941-e4fvj54l	380	26	.	.	.
cord-005941-e4fvj54l	381	1	Diagnosis	diagnosis	NN
cord-005941-e4fvj54l	381	2	is	be	VBZ
cord-005941-e4fvj54l	381	3	usually	usually	RB
cord-005941-e4fvj54l	381	4	made	make	VBN
cord-005941-e4fvj54l	381	5	histologically	histologically	RB
cord-005941-e4fvj54l	381	6	but	but	CC
cord-005941-e4fvj54l	381	7	may	may	MD
cord-005941-e4fvj54l	381	8	also	also	RB
cord-005941-e4fvj54l	381	9	be	be	VB
cord-005941-e4fvj54l	381	10	made	make	VBN
cord-005941-e4fvj54l	381	11	by	by	IN
cord-005941-e4fvj54l	381	12	the	the	DT
cord-005941-e4fvj54l	381	13	demonstration	demonstration	NN
cord-005941-e4fvj54l	381	14	of	of	IN
cord-005941-e4fvj54l	381	15	excessively	excessively	RB
cord-005941-e4fvj54l	381	16	high	high	JJ
cord-005941-e4fvj54l	381	17	SP	sp	NN
cord-005941-e4fvj54l	381	18	-	-	HYPH
cord-005941-e4fvj54l	381	19	A	A	NNP
cord-005941-e4fvj54l	381	20	levels	level	NNS
cord-005941-e4fvj54l	381	21	in	in	IN
cord-005941-e4fvj54l	381	22	BAL	bal	NN
cord-005941-e4fvj54l	381	23	or	or	CC
cord-005941-e4fvj54l	381	24	simply	simply	RB
cord-005941-e4fvj54l	381	25	in	in	IN
cord-005941-e4fvj54l	381	26	sputum	sputum	NN
cord-005941-e4fvj54l	381	27	[	[	-LRB-
cord-005941-e4fvj54l	381	28	113	113	CD
cord-005941-e4fvj54l	381	29	]	]	-RRB-
cord-005941-e4fvj54l	381	30	.	.	.
cord-005941-e4fvj54l	382	1	Further	further	JJ
cord-005941-e4fvj54l	382	2	studies	study	NNS
cord-005941-e4fvj54l	382	3	of	of	IN
cord-005941-e4fvj54l	382	4	surfactant	surfactant	NN
cord-005941-e4fvj54l	382	5	material	material	NN
cord-005941-e4fvj54l	382	6	and	and	CC
cord-005941-e4fvj54l	382	7	alveolar	alveolar	NN
cord-005941-e4fvj54l	382	8	type	type	NN
cord-005941-e4fvj54l	382	9	II	ii	CD
cord-005941-e4fvj54l	382	10	cells	cell	NNS
cord-005941-e4fvj54l	382	11	of	of	IN
cord-005941-e4fvj54l	382	12	these	these	DT
cord-005941-e4fvj54l	382	13	patients	patient	NNS
cord-005941-e4fvj54l	382	14	may	may	MD
cord-005941-e4fvj54l	382	15	possibly	possibly	RB
cord-005941-e4fvj54l	382	16	help	help	VB
cord-005941-e4fvj54l	382	17	to	to	TO
cord-005941-e4fvj54l	382	18	identify	identify	VB
cord-005941-e4fvj54l	382	19	the	the	DT
cord-005941-e4fvj54l	382	20	cause	cause	NN
cord-005941-e4fvj54l	382	21	of	of	IN
cord-005941-e4fvj54l	382	22	this	this	DT
cord-005941-e4fvj54l	382	23	condition	condition	NN
cord-005941-e4fvj54l	382	24	,	,	,
cord-005941-e4fvj54l	382	25	which	which	WDT
cord-005941-e4fvj54l	382	26	is	be	VBZ
cord-005941-e4fvj54l	382	27	presumably	presumably	RB
cord-005941-e4fvj54l	382	28	related	relate	VBN
cord-005941-e4fvj54l	382	29	to	to	IN
cord-005941-e4fvj54l	382	30	a	a	DT
cord-005941-e4fvj54l	382	31	disturbance	disturbance	NN
cord-005941-e4fvj54l	382	32	of	of	IN
cord-005941-e4fvj54l	382	33	the	the	DT
cord-005941-e4fvj54l	382	34	normal	normal	JJ
cord-005941-e4fvj54l	382	35	type	type	NN
cord-005941-e4fvj54l	382	36	II	ii	CD
cord-005941-e4fvj54l	382	37	cell	cell	NN
cord-005941-e4fvj54l	382	38	regulation	regulation	NN
cord-005941-e4fvj54l	382	39	.	.	.
cord-005941-e4fvj54l	383	1	Radiation	radiation	NN
cord-005941-e4fvj54l	383	2	pneumonitis	pneumonitis	NN
cord-005941-e4fvj54l	383	3	and	and	CC
cord-005941-e4fvj54l	383	4	subsequent	subsequent	JJ
cord-005941-e4fvj54l	383	5	fibrosis	fibrosis	NN
cord-005941-e4fvj54l	383	6	are	be	VBP
cord-005941-e4fvj54l	383	7	known	know	VBN
cord-005941-e4fvj54l	383	8	problems	problem	NNS
cord-005941-e4fvj54l	383	9	after	after	IN
cord-005941-e4fvj54l	383	10	radiotherapy	radiotherapy	NN
cord-005941-e4fvj54l	383	11	of	of	IN
cord-005941-e4fvj54l	383	12	thoracic	thoracic	JJ
cord-005941-e4fvj54l	383	13	organs	organ	NNS
cord-005941-e4fvj54l	383	14	.	.	.
cord-005941-e4fvj54l	384	1	Animal	animal	NN
cord-005941-e4fvj54l	384	2	studies	study	NNS
cord-005941-e4fvj54l	384	3	have	have	VBP
cord-005941-e4fvj54l	384	4	shown	show	VBN
cord-005941-e4fvj54l	384	5	that	that	IN
cord-005941-e4fvj54l	384	6	the	the	DT
cord-005941-e4fvj54l	384	7	number	number	NN
cord-005941-e4fvj54l	384	8	of	of	IN
cord-005941-e4fvj54l	384	9	lamellar	lamellar	JJ
cord-005941-e4fvj54l	384	10	bodies	body	NNS
cord-005941-e4fvj54l	384	11	in	in	IN
cord-005941-e4fvj54l	384	12	type	type	NN
cord-005941-e4fvj54l	384	13	II	ii	CD
cord-005941-e4fvj54l	384	14	cells	cell	NNS
cord-005941-e4fvj54l	384	15	drops	drop	VBZ
cord-005941-e4fvj54l	384	16	dramatically	dramatically	RB
cord-005941-e4fvj54l	384	17	immediately	immediately	RB
cord-005941-e4fvj54l	384	18	after	after	IN
cord-005941-e4fvj54l	384	19	radiation	radiation	NN
cord-005941-e4fvj54l	384	20	and	and	CC
cord-005941-e4fvj54l	384	21	that	that	IN
cord-005941-e4fvj54l	384	22	this	this	DT
cord-005941-e4fvj54l	384	23	is	be	VBZ
cord-005941-e4fvj54l	384	24	accompanied	accompany	VBN
cord-005941-e4fvj54l	384	25	by	by	IN
cord-005941-e4fvj54l	384	26	an	an	DT
cord-005941-e4fvj54l	384	27	increase	increase	NN
cord-005941-e4fvj54l	384	28	in	in	IN
cord-005941-e4fvj54l	384	29	lavage	lavage	NN
cord-005941-e4fvj54l	384	30	surfactant	surfactant	NN
cord-005941-e4fvj54l	384	31	content	content	NN
cord-005941-e4fvj54l	384	32	[	[	-LRB-
cord-005941-e4fvj54l	384	33	40	40	CD
cord-005941-e4fvj54l	384	34	]	]	-RRB-
cord-005941-e4fvj54l	384	35	.	.	.
cord-005941-e4fvj54l	385	1	In	in	IN
cord-005941-e4fvj54l	385	2	vitro	vitro	FW
cord-005941-e4fvj54l	385	3	studies	study	NNS
cord-005941-e4fvj54l	385	4	by	by	IN
cord-005941-e4fvj54l	385	5	the	the	DT
cord-005941-e4fvj54l	385	6	same	same	JJ
cord-005941-e4fvj54l	385	7	group	group	NN
cord-005941-e4fvj54l	385	8	demonstrated	demonstrate	VBD
cord-005941-e4fvj54l	385	9	that	that	IN
cord-005941-e4fvj54l	385	10	this	this	DT
cord-005941-e4fvj54l	385	11	is	be	VBZ
cord-005941-e4fvj54l	385	12	a	a	DT
cord-005941-e4fvj54l	385	13	direct	direct	JJ
cord-005941-e4fvj54l	385	14	effect	effect	NN
cord-005941-e4fvj54l	385	15	of	of	IN
cord-005941-e4fvj54l	385	16	radiation	radiation	NN
cord-005941-e4fvj54l	385	17	on	on	IN
cord-005941-e4fvj54l	385	18	type	type	NN
cord-005941-e4fvj54l	385	19	II	ii	CD
cord-005941-e4fvj54l	385	20	cells	cell	NNS
cord-005941-e4fvj54l	385	21	and	and	CC
cord-005941-e4fvj54l	385	22	that	that	IN
cord-005941-e4fvj54l	385	23	these	these	DT
cord-005941-e4fvj54l	385	24	cells	cell	NNS
cord-005941-e4fvj54l	385	25	exhibit	exhibit	VBP
cord-005941-e4fvj54l	385	26	changes	change	NNS
cord-005941-e4fvj54l	385	27	which	which	WDT
cord-005941-e4fvj54l	385	28	may	may	MD
cord-005941-e4fvj54l	385	29	indicate	indicate	VB
cord-005941-e4fvj54l	385	30	a	a	DT
cord-005941-e4fvj54l	385	31	switch	switch	NN
cord-005941-e4fvj54l	385	32	of	of	IN
cord-005941-e4fvj54l	385	33	phospholipid	phospholipid	NN
cord-005941-e4fvj54l	385	34	synthesis	synthesis	NN
cord-005941-e4fvj54l	385	35	to	to	IN
cord-005941-e4fvj54l	385	36	cell	cell	NN
cord-005941-e4fvj54l	385	37	membrane	membrane	NN
cord-005941-e4fvj54l	385	38	repair	repair	NN
cord-005941-e4fvj54l	385	39	after	after	IN
cord-005941-e4fvj54l	385	40	radiation	radiation	NN
cord-005941-e4fvj54l	385	41	damage	damage	NN
cord-005941-e4fvj54l	385	42	.	.	.
cord-005941-e4fvj54l	386	1	These	these	DT
cord-005941-e4fvj54l	386	2	experimental	experimental	JJ
cord-005941-e4fvj54l	386	3	findings	finding	NNS
cord-005941-e4fvj54l	386	4	indicate	indicate	VBP
cord-005941-e4fvj54l	386	5	that	that	IN
cord-005941-e4fvj54l	386	6	radiation	radiation	NN
cord-005941-e4fvj54l	386	7	may	may	MD
cord-005941-e4fvj54l	386	8	lead	lead	VB
cord-005941-e4fvj54l	386	9	to	to	IN
cord-005941-e4fvj54l	386	10	massive	massive	JJ
cord-005941-e4fvj54l	386	11	surfactant	surfactant	NN
cord-005941-e4fvj54l	386	12	secretion	secretion	NN
cord-005941-e4fvj54l	386	13	from	from	IN
cord-005941-e4fvj54l	386	14	type	type	NN
cord-005941-e4fvj54l	386	15	II	ii	CD
cord-005941-e4fvj54l	386	16	cells	cell	NNS
cord-005941-e4fvj54l	386	17	early	early	RB
cord-005941-e4fvj54l	386	18	after	after	IN
cord-005941-e4fvj54l	386	19	exposure	exposure	NN
cord-005941-e4fvj54l	386	20	followed	follow	VBN
cord-005941-e4fvj54l	386	21	by	by	IN
cord-005941-e4fvj54l	386	22	a	a	DT
cord-005941-e4fvj54l	386	23	sharp	sharp	JJ
cord-005941-e4fvj54l	386	24	drop	drop	NN
cord-005941-e4fvj54l	386	25	in	in	IN
cord-005941-e4fvj54l	386	26	further	further	JJ
cord-005941-e4fvj54l	386	27	surfactant	surfactant	NN
cord-005941-e4fvj54l	386	28	synthesis	synthesis	NN
cord-005941-e4fvj54l	386	29	.	.	.
cord-005941-e4fvj54l	387	1	In	in	IN
cord-005941-e4fvj54l	387	2	4	4	CD
cord-005941-e4fvj54l	387	3	patients	patient	NNS
cord-005941-e4fvj54l	387	4	with	with	IN
cord-005941-e4fvj54l	387	5	pleural	pleural	JJ
cord-005941-e4fvj54l	387	6	mesothelioma	mesothelioma	NN
cord-005941-e4fvj54l	387	7	,	,	,
cord-005941-e4fvj54l	387	8	hemithorax	hemithorax	NN
cord-005941-e4fvj54l	387	9	irradiation	irradiation	NN
cord-005941-e4fvj54l	387	10	caused	cause	VBD
cord-005941-e4fvj54l	387	11	protracted	protracted	JJ
cord-005941-e4fvj54l	387	12	accumulation	accumulation	NN
cord-005941-e4fvj54l	387	13	of	of	IN
cord-005941-e4fvj54l	387	14	proteins	protein	NNS
cord-005941-e4fvj54l	387	15	in	in	IN
cord-005941-e4fvj54l	387	16	the	the	DT
cord-005941-e4fvj54l	387	17	alveolar	alveolar	JJ
cord-005941-e4fvj54l	387	18	epithelial	epithelial	JJ
cord-005941-e4fvj54l	387	19	lining	lining	NN
cord-005941-e4fvj54l	387	20	fluid	fluid	NN
cord-005941-e4fvj54l	387	21	which	which	WDT
cord-005941-e4fvj54l	387	22	may	may	MD
cord-005941-e4fvj54l	387	23	inhibit	inhibit	VB
cord-005941-e4fvj54l	387	24	the	the	DT
cord-005941-e4fvj54l	387	25	surface	surface	NN
cord-005941-e4fvj54l	387	26	activity	activity	NN
cord-005941-e4fvj54l	387	27	of	of	IN
cord-005941-e4fvj54l	387	28	surfactant	surfactant	NN
cord-005941-e4fvj54l	387	29	.	.	.
cord-005941-e4fvj54l	388	1	No	no	DT
cord-005941-e4fvj54l	388	2	significant	significant	JJ
cord-005941-e4fvj54l	388	3	changes	change	NNS
cord-005941-e4fvj54l	388	4	in	in	IN
cord-005941-e4fvj54l	388	5	total	total	JJ
cord-005941-e4fvj54l	388	6	phospholipid	phospholipid	NN
cord-005941-e4fvj54l	388	7	content	content	NN
cord-005941-e4fvj54l	388	8	were	be	VBD
cord-005941-e4fvj54l	388	9	found	find	VBN
cord-005941-e4fvj54l	388	10	,	,	,
cord-005941-e4fvj54l	388	11	but	but	CC
cord-005941-e4fvj54l	388	12	PG	PG	NNP
cord-005941-e4fvj54l	388	13	,	,	,
cord-005941-e4fvj54l	388	14	PI	PI	NNP
cord-005941-e4fvj54l	388	15	,	,	,
cord-005941-e4fvj54l	388	16	PC	pc	NN
cord-005941-e4fvj54l	388	17	,	,	,
cord-005941-e4fvj54l	388	18	and	and	CC
cord-005941-e4fvj54l	388	19	SP	SP	NNP
cord-005941-e4fvj54l	388	20	-	-	HYPH
cord-005941-e4fvj54l	388	21	A	A	NNP
cord-005941-e4fvj54l	388	22	levels	level	NNS
cord-005941-e4fvj54l	388	23	were	be	VBD
cord-005941-e4fvj54l	388	24	decrased	decrased	JJ
cord-005941-e4fvj54l	388	25	,	,	,
cord-005941-e4fvj54l	388	26	while	while	IN
cord-005941-e4fvj54l	388	27	the	the	DT
cord-005941-e4fvj54l	388	28	sphingomyelin	sphingomyelin	NN
cord-005941-e4fvj54l	388	29	concentrations	concentration	NNS
cord-005941-e4fvj54l	388	30	were	be	VBD
cord-005941-e4fvj54l	388	31	markedly	markedly	RB
cord-005941-e4fvj54l	388	32	increased	increase	VBN
cord-005941-e4fvj54l	388	33	[	[	-LRB-
cord-005941-e4fvj54l	388	34	62	62	CD
cord-005941-e4fvj54l	388	35	]	]	-RRB-
cord-005941-e4fvj54l	388	36	.	.	.
cord-005941-e4fvj54l	389	1	However	however	RB
cord-005941-e4fvj54l	389	2	,	,	,
cord-005941-e4fvj54l	389	3	the	the	DT
cord-005941-e4fvj54l	389	4	raised	raise	VBN
cord-005941-e4fvj54l	389	5	sphingomyelin	sphingomyelin	NN
cord-005941-e4fvj54l	389	6	levels	level	NNS
cord-005941-e4fvj54l	389	7	in	in	IN
cord-005941-e4fvj54l	389	8	this	this	DT
cord-005941-e4fvj54l	389	9	study	study	NN
cord-005941-e4fvj54l	389	10	probably	probably	RB
cord-005941-e4fvj54l	389	11	originate	originate	VBP
cord-005941-e4fvj54l	389	12	from	from	IN
cord-005941-e4fvj54l	389	13	other	other	JJ
cord-005941-e4fvj54l	389	14	sources	source	NNS
cord-005941-e4fvj54l	389	15	than	than	IN
cord-005941-e4fvj54l	389	16	alveolar	alveolar	NN
cord-005941-e4fvj54l	389	17	surfactant	surfactant	NN
cord-005941-e4fvj54l	389	18	.	.	.
cord-005941-e4fvj54l	390	1	The	the	DT
cord-005941-e4fvj54l	390	2	changes	change	NNS
cord-005941-e4fvj54l	390	3	were	be	VBD
cord-005941-e4fvj54l	390	4	most	most	RBS
cord-005941-e4fvj54l	390	5	evident	evident	JJ
cord-005941-e4fvj54l	390	6	4	4	CD
cord-005941-e4fvj54l	390	7	months	month	NNS
cord-005941-e4fvj54l	390	8	after	after	IN
cord-005941-e4fvj54l	390	9	the	the	DT
cord-005941-e4fvj54l	390	10	completion	completion	NN
cord-005941-e4fvj54l	390	11	of	of	IN
cord-005941-e4fvj54l	390	12	radiotherapy	radiotherapy	NN
cord-005941-e4fvj54l	390	13	.	.	.
cord-005941-e4fvj54l	391	1	Unfortunately	unfortunately	RB
cord-005941-e4fvj54l	391	2	,	,	,
cord-005941-e4fvj54l	391	3	immediate	immediate	JJ
cord-005941-e4fvj54l	391	4	or	or	CC
cord-005941-e4fvj54l	391	5	early	early	JJ
cord-005941-e4fvj54l	391	6	effects	effect	NNS
cord-005941-e4fvj54l	391	7	of	of	IN
cord-005941-e4fvj54l	391	8	radiation	radiation	NN
cord-005941-e4fvj54l	391	9	were	be	VBD
cord-005941-e4fvj54l	391	10	not	not	RB
cord-005941-e4fvj54l	391	11	investigated	investigate	VBN
cord-005941-e4fvj54l	391	12	.	.	.
cord-005941-e4fvj54l	392	1	Further	further	JJ
cord-005941-e4fvj54l	392	2	work	work	NN
cord-005941-e4fvj54l	392	3	will	will	MD
cord-005941-e4fvj54l	392	4	be	be	VB
cord-005941-e4fvj54l	392	5	649	649	CD
cord-005941-e4fvj54l	392	6	necessary	necessary	JJ
cord-005941-e4fvj54l	392	7	to	to	TO
cord-005941-e4fvj54l	392	8	determine	determine	VB
cord-005941-e4fvj54l	392	9	the	the	DT
cord-005941-e4fvj54l	392	10	role	role	NN
cord-005941-e4fvj54l	392	11	of	of	IN
cord-005941-e4fvj54l	392	12	surfactant	surfactant	NN
cord-005941-e4fvj54l	392	13	abnormalities	abnormality	NNS
cord-005941-e4fvj54l	392	14	in	in	IN
cord-005941-e4fvj54l	392	15	the	the	DT
cord-005941-e4fvj54l	392	16	pathogenesis	pathogenesis	NN
cord-005941-e4fvj54l	392	17	of	of	IN
cord-005941-e4fvj54l	392	18	radiation	radiation	NN
cord-005941-e4fvj54l	392	19	pneumonitis	pneumonitis	NN
cord-005941-e4fvj54l	392	20	.	.	.
cord-005941-e4fvj54l	393	1	Drug	drug	NN
cord-005941-e4fvj54l	393	2	-	-	HYPH
cord-005941-e4fvj54l	393	3	induced	induce	VBN
cord-005941-e4fvj54l	393	4	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	393	5	disease	disease	NN
cord-005941-e4fvj54l	393	6	(	(	-LRB-
cord-005941-e4fvj54l	393	7	DIPD	DIPD	NNP
cord-005941-e4fvj54l	393	8	)	)	-RRB-
cord-005941-e4fvj54l	393	9	is	be	VBZ
cord-005941-e4fvj54l	393	10	often	often	RB
cord-005941-e4fvj54l	393	11	accompanied	accompany	VBN
cord-005941-e4fvj54l	393	12	by	by	IN
cord-005941-e4fvj54l	393	13	histological	histological	JJ
cord-005941-e4fvj54l	393	14	changes	change	NNS
cord-005941-e4fvj54l	393	15	of	of	IN
cord-005941-e4fvj54l	393	16	alveolar	alveolar	JJ
cord-005941-e4fvj54l	393	17	type	type	NN
cord-005941-e4fvj54l	393	18	II	ii	CD
cord-005941-e4fvj54l	393	19	cells	cell	NNS
cord-005941-e4fvj54l	393	20	like	like	IN
cord-005941-e4fvj54l	393	21	dysplasia	dysplasia	NN
cord-005941-e4fvj54l	393	22	and	and	CC
cord-005941-e4fvj54l	393	23	proliferation	proliferation	NN
cord-005941-e4fvj54l	393	24	[	[	-LRB-
cord-005941-e4fvj54l	393	25	25	25	CD
cord-005941-e4fvj54l	393	26	,	,	,
cord-005941-e4fvj54l	393	27	26	26	CD
cord-005941-e4fvj54l	393	28	]	]	-RRB-
cord-005941-e4fvj54l	393	29	.	.	.
cord-005941-e4fvj54l	394	1	Therefore	therefore	RB
cord-005941-e4fvj54l	394	2	,	,	,
cord-005941-e4fvj54l	394	3	it	-PRON-	PRP
cord-005941-e4fvj54l	394	4	is	be	VBZ
cord-005941-e4fvj54l	394	5	reasonable	reasonable	JJ
cord-005941-e4fvj54l	394	6	to	to	TO
cord-005941-e4fvj54l	394	7	expect	expect	VB
cord-005941-e4fvj54l	394	8	changes	change	NNS
cord-005941-e4fvj54l	394	9	of	of	IN
cord-005941-e4fvj54l	394	10	the	the	DT
cord-005941-e4fvj54l	394	11	type	type	NN
cord-005941-e4fvj54l	394	12	II	II	NNP
cord-005941-e4fvj54l	394	13	cell	cell	NN
cord-005941-e4fvj54l	394	14	surfactant	surfactant	NN
cord-005941-e4fvj54l	394	15	production	production	NN
cord-005941-e4fvj54l	394	16	in	in	IN
cord-005941-e4fvj54l	394	17	druginduced	druginduced	JJ
cord-005941-e4fvj54l	394	18	lung	lung	NN
cord-005941-e4fvj54l	394	19	injury	injury	NN
cord-005941-e4fvj54l	394	20	.	.	.
cord-005941-e4fvj54l	395	1	However	however	RB
cord-005941-e4fvj54l	395	2	,	,	,
cord-005941-e4fvj54l	395	3	only	only	RB
cord-005941-e4fvj54l	395	4	a	a	DT
cord-005941-e4fvj54l	395	5	few	few	JJ
cord-005941-e4fvj54l	395	6	drugs	drug	NNS
cord-005941-e4fvj54l	395	7	which	which	WDT
cord-005941-e4fvj54l	395	8	are	be	VBP
cord-005941-e4fvj54l	395	9	potentially	potentially	RB
cord-005941-e4fvj54l	395	10	able	able	JJ
cord-005941-e4fvj54l	395	11	to	to	TO
cord-005941-e4fvj54l	395	12	induce	induce	VB
cord-005941-e4fvj54l	395	13	DIPD	DIPD	NNP
cord-005941-e4fvj54l	395	14	have	have	VBP
cord-005941-e4fvj54l	395	15	so	so	RB
cord-005941-e4fvj54l	395	16	far	far	RB
cord-005941-e4fvj54l	395	17	been	be	VBN
cord-005941-e4fvj54l	395	18	investigated	investigate	VBN
cord-005941-e4fvj54l	395	19	in	in	IN
cord-005941-e4fvj54l	395	20	this	this	DT
cord-005941-e4fvj54l	395	21	respect	respect	NN
cord-005941-e4fvj54l	395	22	.	.	.
cord-005941-e4fvj54l	396	1	Polychemotherapy	Polychemotherapy	NNP
cord-005941-e4fvj54l	396	2	has	have	VBZ
cord-005941-e4fvj54l	396	3	in	in	IN
cord-005941-e4fvj54l	396	4	one	one	CD
cord-005941-e4fvj54l	396	5	report	report	NN
cord-005941-e4fvj54l	396	6	been	be	VBN
cord-005941-e4fvj54l	396	7	described	describe	VBN
cord-005941-e4fvj54l	396	8	as	as	IN
cord-005941-e4fvj54l	396	9	inducing	induce	VBG
cord-005941-e4fvj54l	396	10	decreased	decrease	VBD
cord-005941-e4fvj54l	396	11	phosphatidylcholine	phosphatidylcholine	NN
cord-005941-e4fvj54l	396	12	levels	level	NNS
cord-005941-e4fvj54l	396	13	and	and	CC
cord-005941-e4fvj54l	396	14	increased	increase	VBN
cord-005941-e4fvj54l	396	15	phosphatidylglycerol	phosphatidylglycerol	JJ
cord-005941-e4fvj54l	396	16	levels	level	NNS
cord-005941-e4fvj54l	396	17	in	in	IN
cord-005941-e4fvj54l	396	18	BAL	bal	NN
cord-005941-e4fvj54l	396	19	of	of	IN
cord-005941-e4fvj54l	396	20	patients	patient	NNS
cord-005941-e4fvj54l	396	21	with	with	IN
cord-005941-e4fvj54l	396	22	bronchial	bronchial	JJ
cord-005941-e4fvj54l	396	23	carcinoma	carcinoma	NN
cord-005941-e4fvj54l	396	24	[	[	-LRB-
cord-005941-e4fvj54l	396	25	156	156	CD
cord-005941-e4fvj54l	396	26	]	]	-RRB-
cord-005941-e4fvj54l	396	27	.	.	.
cord-005941-e4fvj54l	397	1	Bleomycin	Bleomycin	NNP
cord-005941-e4fvj54l	397	2	is	be	VBZ
cord-005941-e4fvj54l	397	3	an	an	DT
cord-005941-e4fvj54l	397	4	antineoplastic	antineoplastic	JJ
cord-005941-e4fvj54l	397	5	drug	drug	NN
cord-005941-e4fvj54l	397	6	which	which	WDT
cord-005941-e4fvj54l	397	7	has	have	VBZ
cord-005941-e4fvj54l	397	8	a	a	DT
cord-005941-e4fvj54l	397	9	known	know	VBN
cord-005941-e4fvj54l	397	10	capability	capability	NN
cord-005941-e4fvj54l	397	11	to	to	TO
cord-005941-e4fvj54l	397	12	induce	induce	VB
cord-005941-e4fvj54l	397	13	fibrosing	fibrose	VBG
cord-005941-e4fvj54l	397	14	lung	lung	NN
cord-005941-e4fvj54l	397	15	disease	disease	NN
cord-005941-e4fvj54l	397	16	.	.	.
cord-005941-e4fvj54l	398	1	In	in	IN
cord-005941-e4fvj54l	398	2	animal	animal	NN
cord-005941-e4fvj54l	398	3	studies	study	NNS
cord-005941-e4fvj54l	398	4	,	,	,
cord-005941-e4fvj54l	398	5	bleomycin	bleomycin	NN
cord-005941-e4fvj54l	398	6	lung	lung	NN
cord-005941-e4fvj54l	398	7	injury	injury	NN
cord-005941-e4fvj54l	398	8	is	be	VBZ
cord-005941-e4fvj54l	398	9	frequently	frequently	RB
cord-005941-e4fvj54l	398	10	used	use	VBN
cord-005941-e4fvj54l	398	11	as	as	IN
cord-005941-e4fvj54l	398	12	a	a	DT
cord-005941-e4fvj54l	398	13	model	model	NN
cord-005941-e4fvj54l	398	14	of	of	IN
cord-005941-e4fvj54l	398	15	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	398	16	fibrosis	fibrosis	NN
cord-005941-e4fvj54l	398	17	[	[	-LRB-
cord-005941-e4fvj54l	398	18	25	25	CD
cord-005941-e4fvj54l	398	19	]	]	-RRB-
cord-005941-e4fvj54l	398	20	.	.	.
cord-005941-e4fvj54l	399	1	Bleomycin	Bleomycin	NNP
cord-005941-e4fvj54l	399	2	induces	induce	VBZ
cord-005941-e4fvj54l	399	3	proliferation	proliferation	NN
cord-005941-e4fvj54l	399	4	of	of	IN
cord-005941-e4fvj54l	399	5	type	type	NN
cord-005941-e4fvj54l	399	6	II	ii	CD
cord-005941-e4fvj54l	399	7	cells	cell	NNS
cord-005941-e4fvj54l	399	8	and	and	CC
cord-005941-e4fvj54l	399	9	giant	giant	JJ
cord-005941-e4fvj54l	399	10	intracellular	intracellular	JJ
cord-005941-e4fvj54l	399	11	lamellar	lamellar	JJ
cord-005941-e4fvj54l	399	12	bodies	body	NNS
cord-005941-e4fvj54l	399	13	in	in	IN
cord-005941-e4fvj54l	399	14	mice	mouse	NNS
cord-005941-e4fvj54l	399	15	.	.	.
cord-005941-e4fvj54l	400	1	In	in	IN
cord-005941-e4fvj54l	400	2	rats	rat	NNS
cord-005941-e4fvj54l	400	3	with	with	IN
cord-005941-e4fvj54l	400	4	bleomycin	bleomycin	NN
cord-005941-e4fvj54l	400	5	lung	lung	NN
cord-005941-e4fvj54l	400	6	disease	disease	NN
cord-005941-e4fvj54l	400	7	,	,	,
cord-005941-e4fvj54l	400	8	the	the	DT
cord-005941-e4fvj54l	400	9	BAL	bal	NN
cord-005941-e4fvj54l	400	10	after	after	IN
cord-005941-e4fvj54l	400	11	days	day	NNS
cord-005941-e4fvj54l	400	12	14	14	CD
cord-005941-e4fvj54l	400	13	and	and	CC
cord-005941-e4fvj54l	400	14	30	30	CD
cord-005941-e4fvj54l	400	15	revealed	reveal	VBD
cord-005941-e4fvj54l	400	16	increased	increase	VBN
cord-005941-e4fvj54l	400	17	amounts	amount	NNS
cord-005941-e4fvj54l	400	18	of	of	IN
cord-005941-e4fvj54l	400	19	total	total	JJ
cord-005941-e4fvj54l	400	20	phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	400	21	,	,	,
cord-005941-e4fvj54l	400	22	with	with	IN
cord-005941-e4fvj54l	400	23	increased	increase	VBN
cord-005941-e4fvj54l	400	24	percentages	percentage	NNS
cord-005941-e4fvj54l	400	25	of	of	IN
cord-005941-e4fvj54l	400	26	PC	pc	NN
cord-005941-e4fvj54l	400	27	and	and	CC
cord-005941-e4fvj54l	400	28	PI	pi	NN
cord-005941-e4fvj54l	400	29	,	,	,
cord-005941-e4fvj54l	400	30	while	while	IN
cord-005941-e4fvj54l	400	31	that	that	DT
cord-005941-e4fvj54l	400	32	of	of	IN
cord-005941-e4fvj54l	400	33	PG	PG	NNP
cord-005941-e4fvj54l	400	34	was	be	VBD
cord-005941-e4fvj54l	400	35	decreased	decrease	VBN
cord-005941-e4fvj54l	400	36	.	.	.
cord-005941-e4fvj54l	401	1	These	these	DT
cord-005941-e4fvj54l	401	2	changes	change	NNS
cord-005941-e4fvj54l	401	3	coincided	coincide	VBD
cord-005941-e4fvj54l	401	4	with	with	IN
cord-005941-e4fvj54l	401	5	an	an	DT
cord-005941-e4fvj54l	401	6	altered	altered	JJ
cord-005941-e4fvj54l	401	7	lung	lung	NN
cord-005941-e4fvj54l	401	8	compliance	compliance	NN
cord-005941-e4fvj54l	401	9	[	[	-LRB-
cord-005941-e4fvj54l	401	10	173	173	CD
cord-005941-e4fvj54l	401	11	]	]	-RRB-
cord-005941-e4fvj54l	401	12	.	.	.
cord-005941-e4fvj54l	402	1	Another	another	DT
cord-005941-e4fvj54l	402	2	study	study	NN
cord-005941-e4fvj54l	402	3	described	describe	VBD
cord-005941-e4fvj54l	402	4	an	an	DT
cord-005941-e4fvj54l	402	5	initial	initial	JJ
cord-005941-e4fvj54l	402	6	decrease	decrease	NN
cord-005941-e4fvj54l	402	7	of	of	IN
cord-005941-e4fvj54l	402	8	total	total	JJ
cord-005941-e4fvj54l	402	9	phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	402	10	after	after	IN
cord-005941-e4fvj54l	402	11	4	4	CD
cord-005941-e4fvj54l	402	12	days	day	NNS
cord-005941-e4fvj54l	402	13	and	and	CC
cord-005941-e4fvj54l	402	14	a	a	DT
cord-005941-e4fvj54l	402	15	subsequent	subsequent	JJ
cord-005941-e4fvj54l	402	16	2.5-fold	2.5-fold	CD
cord-005941-e4fvj54l	402	17	increase	increase	NN
cord-005941-e4fvj54l	402	18	over	over	IN
cord-005941-e4fvj54l	402	19	control	control	NN
cord-005941-e4fvj54l	402	20	animals	animal	NNS
cord-005941-e4fvj54l	402	21	on	on	IN
cord-005941-e4fvj54l	402	22	days	day	NNS
cord-005941-e4fvj54l	402	23	21	21	CD
cord-005941-e4fvj54l	402	24	and	and	CC
cord-005941-e4fvj54l	402	25	28	28	CD
cord-005941-e4fvj54l	402	26	[	[	-LRB-
cord-005941-e4fvj54l	402	27	80	80	CD
cord-005941-e4fvj54l	402	28	]	]	-RRB-
cord-005941-e4fvj54l	402	29	.	.	.
cord-005941-e4fvj54l	403	1	The	the	DT
cord-005941-e4fvj54l	403	2	percentage	percentage	NN
cord-005941-e4fvj54l	403	3	of	of	IN
cord-005941-e4fvj54l	403	4	PG	PG	NNP
cord-005941-e4fvj54l	403	5	was	be	VBD
cord-005941-e4fvj54l	403	6	reduced	reduce	VBN
cord-005941-e4fvj54l	403	7	,	,	,
cord-005941-e4fvj54l	403	8	and	and	CC
cord-005941-e4fvj54l	403	9	that	that	DT
cord-005941-e4fvj54l	403	10	of	of	IN
cord-005941-e4fvj54l	403	11	PI	PI	NNP
cord-005941-e4fvj54l	403	12	was	be	VBD
cord-005941-e4fvj54l	403	13	increased	increase	VBN
cord-005941-e4fvj54l	403	14	.	.	.
cord-005941-e4fvj54l	404	1	SP	SP	NNP
cord-005941-e4fvj54l	404	2	-	-	HYPH
cord-005941-e4fvj54l	404	3	A	A	NNP
cord-005941-e4fvj54l	404	4	levels	level	NNS
cord-005941-e4fvj54l	404	5	did	do	VBD
cord-005941-e4fvj54l	404	6	not	not	RB
cord-005941-e4fvj54l	404	7	change	change	VB
cord-005941-e4fvj54l	404	8	throughout	throughout	IN
cord-005941-e4fvj54l	404	9	the	the	DT
cord-005941-e4fvj54l	404	10	experiment	experiment	NN
cord-005941-e4fvj54l	404	11	.	.	.
cord-005941-e4fvj54l	405	1	From	from	IN
cord-005941-e4fvj54l	405	2	these	these	DT
cord-005941-e4fvj54l	405	3	results	result	NNS
cord-005941-e4fvj54l	405	4	,	,	,
cord-005941-e4fvj54l	405	5	a	a	DT
cord-005941-e4fvj54l	405	6	rather	rather	RB
cord-005941-e4fvj54l	405	7	general	general	JJ
cord-005941-e4fvj54l	405	8	conclusion	conclusion	NN
cord-005941-e4fvj54l	405	9	was	be	VBD
cord-005941-e4fvj54l	405	10	drawn	draw	VBN
cord-005941-e4fvj54l	405	11	that	that	IN
cord-005941-e4fvj54l	405	12	SP	SP	NNP
cord-005941-e4fvj54l	405	13	-	-	HYPH
cord-005941-e4fvj54l	405	14	A	A	NNP
cord-005941-e4fvj54l	405	15	is	be	VBZ
cord-005941-e4fvj54l	405	16	insensitive	insensitive	JJ
cord-005941-e4fvj54l	405	17	to	to	IN
cord-005941-e4fvj54l	405	18	lung	lung	NN
cord-005941-e4fvj54l	405	19	injury	injury	NN
cord-005941-e4fvj54l	405	20	and	and	CC
cord-005941-e4fvj54l	405	21	repair	repair	NN
cord-005941-e4fvj54l	405	22	.	.	.
cord-005941-e4fvj54l	406	1	Decreased	decrease	VBN
cord-005941-e4fvj54l	406	2	BAL	bal	NN
cord-005941-e4fvj54l	406	3	phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	406	4	were	be	VBD
cord-005941-e4fvj54l	406	5	also	also	RB
cord-005941-e4fvj54l	406	6	found	find	VBN
cord-005941-e4fvj54l	406	7	in	in	IN
cord-005941-e4fvj54l	406	8	the	the	DT
cord-005941-e4fvj54l	406	9	early	early	JJ
cord-005941-e4fvj54l	406	10	phase	phase	NN
cord-005941-e4fvj54l	406	11	of	of	IN
cord-005941-e4fvj54l	406	12	fibrosis	fibrosis	NN
cord-005941-e4fvj54l	406	13	in	in	IN
cord-005941-e4fvj54l	406	14	hamsters	hamster	NNS
cord-005941-e4fvj54l	406	15	.	.	.
cord-005941-e4fvj54l	407	1	The	the	DT
cord-005941-e4fvj54l	407	2	surface	surface	NN
cord-005941-e4fvj54l	407	3	-	-	HYPH
cord-005941-e4fvj54l	407	4	active	active	JJ
cord-005941-e4fvj54l	407	5	properties	property	NNS
cord-005941-e4fvj54l	407	6	of	of	IN
cord-005941-e4fvj54l	407	7	surfactant	surfactant	NN
cord-005941-e4fvj54l	407	8	were	be	VBD
cord-005941-e4fvj54l	407	9	inhibited	inhibit	VBN
cord-005941-e4fvj54l	407	10	and	and	CC
cord-005941-e4fvj54l	407	11	lung	lung	NN
cord-005941-e4fvj54l	407	12	pressure	pressure	NN
cord-005941-e4fvj54l	407	13	-	-	HYPH
cord-005941-e4fvj54l	407	14	volume	volume	NN
cord-005941-e4fvj54l	407	15	curves	curve	NNS
cord-005941-e4fvj54l	407	16	deteriorated	deteriorate	VBD
cord-005941-e4fvj54l	407	17	[	[	-LRB-
cord-005941-e4fvj54l	407	18	133	133	CD
cord-005941-e4fvj54l	407	19	]	]	-RRB-
cord-005941-e4fvj54l	407	20	.	.	.
cord-005941-e4fvj54l	408	1	In	in	IN
cord-005941-e4fvj54l	408	2	conclusion	conclusion	NN
cord-005941-e4fvj54l	408	3	,	,	,
cord-005941-e4fvj54l	408	4	bleomycin	bleomycin	NN
cord-005941-e4fvj54l	408	5	apparently	apparently	RB
cord-005941-e4fvj54l	408	6	leads	lead	VBZ
cord-005941-e4fvj54l	408	7	to	to	IN
cord-005941-e4fvj54l	408	8	a	a	DT
cord-005941-e4fvj54l	408	9	decrease	decrease	NN
cord-005941-e4fvj54l	408	10	of	of	IN
cord-005941-e4fvj54l	408	11	total	total	JJ
cord-005941-e4fvj54l	408	12	phospholipid	phospholipid	NN
cord-005941-e4fvj54l	408	13	values	value	NNS
cord-005941-e4fvj54l	408	14	within	within	IN
cord-005941-e4fvj54l	408	15	the	the	DT
cord-005941-e4fvj54l	408	16	first	first	JJ
cord-005941-e4fvj54l	408	17	days	day	NNS
cord-005941-e4fvj54l	408	18	of	of	IN
cord-005941-e4fvj54l	408	19	lung	lung	NN
cord-005941-e4fvj54l	408	20	injury	injury	NN
cord-005941-e4fvj54l	408	21	,	,	,
cord-005941-e4fvj54l	408	22	followed	follow	VBN
cord-005941-e4fvj54l	408	23	by	by	IN
cord-005941-e4fvj54l	408	24	an	an	DT
cord-005941-e4fvj54l	408	25	increase	increase	NN
cord-005941-e4fvj54l	408	26	above	above	IN
cord-005941-e4fvj54l	408	27	normal	normal	JJ
cord-005941-e4fvj54l	408	28	values	value	NNS
cord-005941-e4fvj54l	408	29	with	with	IN
cord-005941-e4fvj54l	408	30	a	a	DT
cord-005941-e4fvj54l	408	31	decreased	decrease	VBN
cord-005941-e4fvj54l	408	32	PG	pg	NN
cord-005941-e4fvj54l	408	33	:	:	:
cord-005941-e4fvj54l	408	34	P	p	NN
cord-005941-e4fvj54l	408	35	!	!	.
cord-005941-e4fvj54l	408	36	ratio	ratio	NN
cord-005941-e4fvj54l	408	37	.	.	.
cord-005941-e4fvj54l	409	1	It	-PRON-	PRP
cord-005941-e4fvj54l	409	2	remains	remain	VBZ
cord-005941-e4fvj54l	409	3	to	to	TO
cord-005941-e4fvj54l	409	4	be	be	VB
cord-005941-e4fvj54l	409	5	confirmed	confirm	VBN
cord-005941-e4fvj54l	409	6	that	that	IN
cord-005941-e4fvj54l	409	7	these	these	DT
cord-005941-e4fvj54l	409	8	observations	observation	NNS
cord-005941-e4fvj54l	409	9	adequately	adequately	RB
cord-005941-e4fvj54l	409	10	and	and	CC
cord-005941-e4fvj54l	409	11	specifically	specifically	RB
cord-005941-e4fvj54l	409	12	reflect	reflect	VB
cord-005941-e4fvj54l	409	13	the	the	DT
cord-005941-e4fvj54l	409	14	injury	injury	NN
cord-005941-e4fvj54l	409	15	of	of	IN
cord-005941-e4fvj54l	409	16	alveolar	alveolar	JJ
cord-005941-e4fvj54l	409	17	type	type	NN
cord-005941-e4fvj54l	409	18	II	ii	CD
cord-005941-e4fvj54l	409	19	cells	cell	NNS
cord-005941-e4fvj54l	409	20	.	.	.
cord-005941-e4fvj54l	410	1	It	-PRON-	PRP
cord-005941-e4fvj54l	410	2	seems	seem	VBZ
cord-005941-e4fvj54l	410	3	surprising	surprising	JJ
cord-005941-e4fvj54l	410	4	that	that	IN
cord-005941-e4fvj54l	410	5	SP	SP	NNP
cord-005941-e4fvj54l	410	6	-	-	HYPH
cord-005941-e4fvj54l	410	7	A	A	NNP
cord-005941-e4fvj54l	410	8	,	,	,
cord-005941-e4fvj54l	410	9	a	a	DT
cord-005941-e4fvj54l	410	10	more	more	RBR
cord-005941-e4fvj54l	410	11	specific	specific	JJ
cord-005941-e4fvj54l	410	12	secretory	secretory	JJ
cord-005941-e4fvj54l	410	13	product	product	NN
cord-005941-e4fvj54l	410	14	of	of	IN
cord-005941-e4fvj54l	410	15	alveolar	alveolar	JJ
cord-005941-e4fvj54l	410	16	type	type	NN
cord-005941-e4fvj54l	410	17	II	ii	CD
cord-005941-e4fvj54l	410	18	cells	cell	NNS
cord-005941-e4fvj54l	410	19	than	than	IN
cord-005941-e4fvj54l	410	20	phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	410	21	,	,	,
cord-005941-e4fvj54l	410	22	did	do	VBD
cord-005941-e4fvj54l	410	23	not	not	RB
cord-005941-e4fvj54l	410	24	change	change	VB
cord-005941-e4fvj54l	410	25	in	in	IN
cord-005941-e4fvj54l	410	26	the	the	DT
cord-005941-e4fvj54l	410	27	one	one	CD
cord-005941-e4fvj54l	410	28	study	study	NN
cord-005941-e4fvj54l	410	29	cited	cite	VBN
cord-005941-e4fvj54l	410	30	above	above	RB
cord-005941-e4fvj54l	410	31	.	.	.
cord-005941-e4fvj54l	411	1	The	the	DT
cord-005941-e4fvj54l	411	2	conclusion	conclusion	NN
cord-005941-e4fvj54l	411	3	that	that	IN
cord-005941-e4fvj54l	411	4	SP	SP	NNP
cord-005941-e4fvj54l	411	5	-	-	HYPH
cord-005941-e4fvj54l	411	6	A	A	NNP
cord-005941-e4fvj54l	411	7	is	be	VBZ
cord-005941-e4fvj54l	411	8	insensitive	insensitive	JJ
cord-005941-e4fvj54l	411	9	to	to	IN
cord-005941-e4fvj54l	411	10	lung	lung	NN
cord-005941-e4fvj54l	411	11	injury	injury	NN
cord-005941-e4fvj54l	411	12	is	be	VBZ
cord-005941-e4fvj54l	411	13	not	not	RB
cord-005941-e4fvj54l	411	14	convincing	convincing	JJ
cord-005941-e4fvj54l	411	15	,	,	,
cord-005941-e4fvj54l	411	16	since	since	IN
cord-005941-e4fvj54l	411	17	changes	change	NNS
cord-005941-e4fvj54l	411	18	in	in	IN
cord-005941-e4fvj54l	411	19	SP	SP	NNP
cord-005941-e4fvj54l	411	20	-	-	HYPH
cord-005941-e4fvj54l	411	21	A	A	NNP
cord-005941-e4fvj54l	411	22	levels	level	NNS
cord-005941-e4fvj54l	411	23	have	have	VBP
cord-005941-e4fvj54l	411	24	been	be	VBN
cord-005941-e4fvj54l	411	25	reported	report	VBN
cord-005941-e4fvj54l	411	26	in	in	IN
cord-005941-e4fvj54l	411	27	idio	idio	JJ
cord-005941-e4fvj54l	411	28	-	-	HYPH
cord-005941-e4fvj54l	411	29	pathic	pathic	JJ
cord-005941-e4fvj54l	411	30	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	411	31	fibrosis	fibrosis	NN
cord-005941-e4fvj54l	411	32	and	and	CC
cord-005941-e4fvj54l	411	33	other	other	JJ
cord-005941-e4fvj54l	411	34	lung	lung	NN
cord-005941-e4fvj54l	411	35	disorders	disorder	NNS
cord-005941-e4fvj54l	411	36	.	.	.
cord-005941-e4fvj54l	412	1	It	-PRON-	PRP
cord-005941-e4fvj54l	412	2	has	have	VBZ
cord-005941-e4fvj54l	412	3	been	be	VBN
cord-005941-e4fvj54l	412	4	hypothesized	hypothesize	VBN
cord-005941-e4fvj54l	412	5	that	that	IN
cord-005941-e4fvj54l	412	6	an	an	DT
cord-005941-e4fvj54l	412	7	increase	increase	NN
cord-005941-e4fvj54l	412	8	of	of	IN
cord-005941-e4fvj54l	412	9	alveolar	alveolar	JJ
cord-005941-e4fvj54l	412	10	surfactant	surfactant	NN
cord-005941-e4fvj54l	412	11	material	material	NN
cord-005941-e4fvj54l	412	12	may	may	MD
cord-005941-e4fvj54l	412	13	contribute	contribute	VB
cord-005941-e4fvj54l	412	14	to	to	IN
cord-005941-e4fvj54l	412	15	the	the	DT
cord-005941-e4fvj54l	412	16	pathogenesis	pathogenesis	NN
cord-005941-e4fvj54l	412	17	of	of	IN
cord-005941-e4fvj54l	412	18	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	412	19	fibrosis	fibrosis	NN
cord-005941-e4fvj54l	412	20	by	by	IN
cord-005941-e4fvj54l	412	21	activating	activate	VBG
cord-005941-e4fvj54l	412	22	alveolar	alveolar	JJ
cord-005941-e4fvj54l	412	23	macrophages	macrophage	NNS
cord-005941-e4fvj54l	412	24	which	which	WDT
cord-005941-e4fvj54l	412	25	in	in	IN
cord-005941-e4fvj54l	412	26	turn	turn	NN
cord-005941-e4fvj54l	412	27	stimulate	stimulate	VBP
cord-005941-e4fvj54l	412	28	fibroblasts	fibroblast	NNS
cord-005941-e4fvj54l	412	29	[	[	-LRB-
cord-005941-e4fvj54l	412	30	39	39	CD
cord-005941-e4fvj54l	412	31	]	]	-RRB-
cord-005941-e4fvj54l	412	32	.	.	.
cord-005941-e4fvj54l	413	1	However	however	RB
cord-005941-e4fvj54l	413	2	,	,	,
cord-005941-e4fvj54l	413	3	there	there	EX
cord-005941-e4fvj54l	413	4	is	be	VBZ
cord-005941-e4fvj54l	413	5	no	no	DT
cord-005941-e4fvj54l	413	6	experimental	experimental	JJ
cord-005941-e4fvj54l	413	7	support	support	NN
cord-005941-e4fvj54l	413	8	to	to	IN
cord-005941-e4fvj54l	413	9	this	this	DT
cord-005941-e4fvj54l	413	10	idea	idea	NN
cord-005941-e4fvj54l	413	11	,	,	,
cord-005941-e4fvj54l	413	12	and	and	CC
cord-005941-e4fvj54l	413	13	from	from	IN
cord-005941-e4fvj54l	413	14	a	a	DT
cord-005941-e4fvj54l	413	15	clinical	clinical	JJ
cord-005941-e4fvj54l	413	16	point	point	NN
cord-005941-e4fvj54l	413	17	of	of	IN
cord-005941-e4fvj54l	413	18	view	view	NN
cord-005941-e4fvj54l	413	19	,	,	,
cord-005941-e4fvj54l	413	20	this	this	DT
cord-005941-e4fvj54l	413	21	hypothesis	hypothesis	NN
cord-005941-e4fvj54l	413	22	appears	appear	VBZ
cord-005941-e4fvj54l	413	23	doubtful	doubtful	JJ
cord-005941-e4fvj54l	413	24	since	since	IN
cord-005941-e4fvj54l	413	25	most	most	JJS
cord-005941-e4fvj54l	413	26	patients	patient	NNS
cord-005941-e4fvj54l	413	27	with	with	IN
cord-005941-e4fvj54l	413	28	alveolar	alveolar	NN
cord-005941-e4fvj54l	413	29	proteinosis	proteinosis	NN
cord-005941-e4fvj54l	413	30	do	do	VBP
cord-005941-e4fvj54l	413	31	not	not	RB
cord-005941-e4fvj54l	413	32	tend	tend	VB
cord-005941-e4fvj54l	413	33	to	to	TO
cord-005941-e4fvj54l	413	34	develop	develop	VB
cord-005941-e4fvj54l	413	35	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	413	36	fibrosis	fibrosis	NN
cord-005941-e4fvj54l	413	37	.	.	.
cord-005941-e4fvj54l	414	1	Amphiphilic	amphiphilic	JJ
cord-005941-e4fvj54l	414	2	drugs	drug	NNS
cord-005941-e4fvj54l	414	3	like	like	IN
cord-005941-e4fvj54l	414	4	amiodarone	amiodarone	NN
cord-005941-e4fvj54l	414	5	,	,	,
cord-005941-e4fvj54l	414	6	propranolol	propranolol	NN
cord-005941-e4fvj54l	414	7	,	,	,
cord-005941-e4fvj54l	414	8	chloramphenicol	chloramphenicol	NN
cord-005941-e4fvj54l	414	9	,	,	,
cord-005941-e4fvj54l	414	10	and	and	CC
cord-005941-e4fvj54l	415	1	chlorpromazine	chlorpromazine	NNP
cord-005941-e4fvj54l	415	2	may	may	MD
cord-005941-e4fvj54l	415	3	interact	interact	VB
cord-005941-e4fvj54l	415	4	with	with	IN
cord-005941-e4fvj54l	415	5	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	415	6	phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	415	7	and	and	CC
cord-005941-e4fvj54l	415	8	thus	thus	RB
cord-005941-e4fvj54l	415	9	surfactant	surfactant	NN
cord-005941-e4fvj54l	415	10	phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	415	11	,	,	,
cord-005941-e4fvj54l	415	12	causing	cause	VBG
cord-005941-e4fvj54l	415	13	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	415	14	phospholipidosis	phospholipidosis	NN
cord-005941-e4fvj54l	415	15	.	.	.
cord-005941-e4fvj54l	416	1	A	a	DT
cord-005941-e4fvj54l	416	2	proposed	propose	VBN
cord-005941-e4fvj54l	416	3	mechanism	mechanism	NN
cord-005941-e4fvj54l	416	4	is	be	VBZ
cord-005941-e4fvj54l	416	5	that	that	IN
cord-005941-e4fvj54l	416	6	normal	normal	JJ
cord-005941-e4fvj54l	416	7	phospholipid	phospholipid	NN
cord-005941-e4fvj54l	416	8	degradation	degradation	NN
cord-005941-e4fvj54l	416	9	is	be	VBZ
cord-005941-e4fvj54l	416	10	impaired	impair	VBN
cord-005941-e4fvj54l	416	11	by	by	IN
cord-005941-e4fvj54l	416	12	binding	bind	VBG
cord-005941-e4fvj54l	416	13	to	to	IN
cord-005941-e4fvj54l	416	14	the	the	DT
cord-005941-e4fvj54l	416	15	drugs	drug	NNS
cord-005941-e4fvj54l	416	16	.	.	.
cord-005941-e4fvj54l	417	1	Inhibition	inhibition	NN
cord-005941-e4fvj54l	417	2	of	of	IN
cord-005941-e4fvj54l	417	3	phospholipases	phospholipase	NNS
cord-005941-e4fvj54l	417	4	may	may	MD
cord-005941-e4fvj54l	417	5	also	also	RB
cord-005941-e4fvj54l	417	6	be	be	VB
cord-005941-e4fvj54l	417	7	involved	involve	VBN
cord-005941-e4fvj54l	417	8	[	[	-LRB-
cord-005941-e4fvj54l	417	9	87	87	CD
cord-005941-e4fvj54l	417	10	]	]	-RRB-
cord-005941-e4fvj54l	417	11	.	.	.
cord-005941-e4fvj54l	418	1	It	-PRON-	PRP
cord-005941-e4fvj54l	418	2	seems	seem	VBZ
cord-005941-e4fvj54l	418	3	reasonable	reasonable	JJ
cord-005941-e4fvj54l	418	4	to	to	TO
cord-005941-e4fvj54l	418	5	suspect	suspect	VB
cord-005941-e4fvj54l	418	6	surfactant	surfactant	NN
cord-005941-e4fvj54l	418	7	abnormalities	abnormality	NNS
cord-005941-e4fvj54l	418	8	in	in	IN
cord-005941-e4fvj54l	418	9	many	many	JJ
cord-005941-e4fvj54l	418	10	other	other	JJ
cord-005941-e4fvj54l	418	11	drug	drug	NN
cord-005941-e4fvj54l	418	12	-	-	HYPH
cord-005941-e4fvj54l	418	13	induced	induce	VBN
cord-005941-e4fvj54l	418	14	lung	lung	NN
cord-005941-e4fvj54l	418	15	disorders	disorder	NNS
cord-005941-e4fvj54l	418	16	because	because	IN
cord-005941-e4fvj54l	418	17	DIPD	DIPD	NNP
cord-005941-e4fvj54l	418	18	is	be	VBZ
cord-005941-e4fvj54l	418	19	often	often	RB
cord-005941-e4fvj54l	418	20	associated	associate	VBN
cord-005941-e4fvj54l	418	21	with	with	IN
cord-005941-e4fvj54l	418	22	morphological	morphological	JJ
cord-005941-e4fvj54l	418	23	alterations	alteration	NNS
cord-005941-e4fvj54l	418	24	of	of	IN
cord-005941-e4fvj54l	418	25	type	type	NN
cord-005941-e4fvj54l	418	26	II	ii	CD
cord-005941-e4fvj54l	418	27	cells	cell	NNS
cord-005941-e4fvj54l	418	28	.	.	.
cord-005941-e4fvj54l	419	1	As	as	IN
cord-005941-e4fvj54l	419	2	an	an	DT
cord-005941-e4fvj54l	419	3	example	example	NN
cord-005941-e4fvj54l	419	4	,	,	,
cord-005941-e4fvj54l	419	5	we	-PRON-	PRP
cord-005941-e4fvj54l	419	6	recently	recently	RB
cord-005941-e4fvj54l	419	7	observed	observe	VBD
cord-005941-e4fvj54l	419	8	morphological	morphological	JJ
cord-005941-e4fvj54l	419	9	changes	change	NNS
cord-005941-e4fvj54l	419	10	of	of	IN
cord-005941-e4fvj54l	419	11	alveolar	alveolar	JJ
cord-005941-e4fvj54l	419	12	type	type	NN
cord-005941-e4fvj54l	419	13	II	ii	CD
cord-005941-e4fvj54l	419	14	cells	cell	NNS
cord-005941-e4fvj54l	419	15	in	in	IN
cord-005941-e4fvj54l	419	16	a	a	DT
cord-005941-e4fvj54l	419	17	case	case	NN
cord-005941-e4fvj54l	419	18	of	of	IN
cord-005941-e4fvj54l	419	19	acute	acute	JJ
cord-005941-e4fvj54l	419	20	mesalazine	mesalazine	NN
cord-005941-e4fvj54l	419	21	alveolitis	alveolitis	NNP
cord-005941-e4fvj54l	419	22	[	[	-LRB-
cord-005941-e4fvj54l	419	23	187	187	CD
cord-005941-e4fvj54l	419	24	]	]	-RRB-
cord-005941-e4fvj54l	419	25	.	.	.
cord-005941-e4fvj54l	420	1	Subsequent	subsequent	JJ
cord-005941-e4fvj54l	420	2	analysis	analysis	NN
cord-005941-e4fvj54l	420	3	of	of	IN
cord-005941-e4fvj54l	420	4	the	the	DT
cord-005941-e4fvj54l	420	5	BAL	BAL	NNP
cord-005941-e4fvj54l	420	6	fluid	fluid	NN
cord-005941-e4fvj54l	420	7	of	of	IN
cord-005941-e4fvj54l	420	8	this	this	DT
cord-005941-e4fvj54l	420	9	patient	patient	NN
cord-005941-e4fvj54l	420	10	revealed	reveal	VBD
cord-005941-e4fvj54l	420	11	an	an	DT
cord-005941-e4fvj54l	420	12	increase	increase	NN
cord-005941-e4fvj54l	420	13	of	of	IN
cord-005941-e4fvj54l	420	14	SP	SP	NNP
cord-005941-e4fvj54l	420	15	-	-	HYPH
cord-005941-e4fvj54l	420	16	A	A	NNP
cord-005941-e4fvj54l	420	17	content	content	NN
cord-005941-e4fvj54l	420	18	approximately	approximately	RB
cord-005941-e4fvj54l	420	19	10-fold	10-fold	JJ
cord-005941-e4fvj54l	420	20	above	above	IN
cord-005941-e4fvj54l	420	21	healthy	healthy	JJ
cord-005941-e4fvj54l	420	22	controls	control	NNS
cord-005941-e4fvj54l	420	23	.	.	.
cord-005941-e4fvj54l	421	1	Byssinosis	Byssinosis	NNP
cord-005941-e4fvj54l	421	2	is	be	VBZ
cord-005941-e4fvj54l	421	3	a	a	DT
cord-005941-e4fvj54l	421	4	lung	lung	NN
cord-005941-e4fvj54l	421	5	disease	disease	NN
cord-005941-e4fvj54l	421	6	observed	observe	VBN
cord-005941-e4fvj54l	421	7	in	in	IN
cord-005941-e4fvj54l	421	8	cotton	cotton	NN
cord-005941-e4fvj54l	421	9	workers	worker	NNS
cord-005941-e4fvj54l	421	10	.	.	.
cord-005941-e4fvj54l	422	1	Clinically	clinically	RB
cord-005941-e4fvj54l	422	2	,	,	,
cord-005941-e4fvj54l	422	3	patients	patient	NNS
cord-005941-e4fvj54l	422	4	present	present	JJ
cord-005941-e4fvj54l	422	5	with	with	IN
cord-005941-e4fvj54l	422	6	fever	fever	NN
cord-005941-e4fvj54l	422	7	,	,	,
cord-005941-e4fvj54l	422	8	flulike	flulike	JJ
cord-005941-e4fvj54l	422	9	symptoms	symptom	NNS
cord-005941-e4fvj54l	422	10	,	,	,
cord-005941-e4fvj54l	422	11	and	and	CC
cord-005941-e4fvj54l	422	12	bronchoconstriction	bronchoconstriction	NN
cord-005941-e4fvj54l	422	13	.	.	.
cord-005941-e4fvj54l	423	1	Lipopolysaccharides	Lipopolysaccharides	NNP
cord-005941-e4fvj54l	423	2	from	from	IN
cord-005941-e4fvj54l	423	3	gram	gram	JJ
cord-005941-e4fvj54l	423	4	-	-	HYPH
cord-005941-e4fvj54l	423	5	negative	negative	JJ
cord-005941-e4fvj54l	423	6	bacteria	bacteria	NNS
cord-005941-e4fvj54l	423	7	found	find	VBN
cord-005941-e4fvj54l	423	8	in	in	IN
cord-005941-e4fvj54l	423	9	respirable	respirable	JJ
cord-005941-e4fvj54l	423	10	cotton	cotton	NN
cord-005941-e4fvj54l	423	11	dusts	dust	NNS
cord-005941-e4fvj54l	423	12	are	be	VBP
cord-005941-e4fvj54l	423	13	thought	think	VBN
cord-005941-e4fvj54l	423	14	to	to	TO
cord-005941-e4fvj54l	423	15	be	be	VB
cord-005941-e4fvj54l	423	16	responsible	responsible	JJ
cord-005941-e4fvj54l	423	17	for	for	IN
cord-005941-e4fvj54l	423	18	this	this	DT
cord-005941-e4fvj54l	423	19	disease	disease	NN
cord-005941-e4fvj54l	423	20	.	.	.
cord-005941-e4fvj54l	424	1	A	a	DT
cord-005941-e4fvj54l	424	2	recently	recently	RB
cord-005941-e4fvj54l	424	3	published	publish	VBN
cord-005941-e4fvj54l	424	4	in	in	IN
cord-005941-e4fvj54l	424	5	vitro	vitro	FW
cord-005941-e4fvj54l	424	6	study	study	NN
cord-005941-e4fvj54l	424	7	suggests	suggest	VBZ
cord-005941-e4fvj54l	424	8	that	that	IN
cord-005941-e4fvj54l	424	9	cotton	cotton	NN
cord-005941-e4fvj54l	424	10	extracts	extract	NNS
cord-005941-e4fvj54l	424	11	cause	cause	VBP
cord-005941-e4fvj54l	424	12	biophysical	biophysical	JJ
cord-005941-e4fvj54l	424	13	alterations	alteration	NNS
cord-005941-e4fvj54l	424	14	of	of	IN
cord-005941-e4fvj54l	424	15	the	the	DT
cord-005941-e4fvj54l	424	16	lung	lung	NN
cord-005941-e4fvj54l	424	17	surfactant	surfactant	NN
cord-005941-e4fvj54l	424	18	[	[	-LRB-
cord-005941-e4fvj54l	424	19	30	30	CD
cord-005941-e4fvj54l	424	20	]	]	-RRB-
cord-005941-e4fvj54l	424	21	.	.	.
cord-005941-e4fvj54l	425	1	It	-PRON-	PRP
cord-005941-e4fvj54l	425	2	is	be	VBZ
cord-005941-e4fvj54l	425	3	hypothesized	hypothesize	VBN
cord-005941-e4fvj54l	425	4	that	that	IN
cord-005941-e4fvj54l	425	5	these	these	DT
cord-005941-e4fvj54l	425	6	effects	effect	NNS
cord-005941-e4fvj54l	425	7	play	play	VBP
cord-005941-e4fvj54l	425	8	a	a	DT
cord-005941-e4fvj54l	425	9	part	part	NN
cord-005941-e4fvj54l	425	10	in	in	IN
cord-005941-e4fvj54l	425	11	the	the	DT
cord-005941-e4fvj54l	425	12	pathogenesis	pathogenesis	NN
cord-005941-e4fvj54l	425	13	of	of	IN
cord-005941-e4fvj54l	425	14	byssinosis	byssinosis	NN
cord-005941-e4fvj54l	425	15	.	.	.
cord-005941-e4fvj54l	426	1	BAL	BAL	NNP
cord-005941-e4fvj54l	426	2	from	from	IN
cord-005941-e4fvj54l	426	3	lung	lung	NN
cord-005941-e4fvj54l	426	4	transplants	transplant	NNS
cord-005941-e4fvj54l	426	5	of	of	IN
cord-005941-e4fvj54l	426	6	11	11	CD
cord-005941-e4fvj54l	426	7	dogs	dog	NNS
cord-005941-e4fvj54l	426	8	were	be	VBD
cord-005941-e4fvj54l	426	9	recently	recently	RB
cord-005941-e4fvj54l	426	10	investigated	investigate	VBN
cord-005941-e4fvj54l	426	11	with	with	IN
cord-005941-e4fvj54l	426	12	the	the	DT
cord-005941-e4fvj54l	426	13	principle	principle	JJ
cord-005941-e4fvj54l	426	14	aim	aim	NN
cord-005941-e4fvj54l	426	15	of	of	IN
cord-005941-e4fvj54l	426	16	finding	find	VBG
cord-005941-e4fvj54l	426	17	surfactant	surfactant	NN
cord-005941-e4fvj54l	426	18	phospholipid	phospholipid	NN
cord-005941-e4fvj54l	426	19	changes	change	NNS
cord-005941-e4fvj54l	426	20	specific	specific	JJ
cord-005941-e4fvj54l	426	21	to	to	IN
cord-005941-e4fvj54l	426	22	infection	infection	NN
cord-005941-e4fvj54l	426	23	or	or	CC
cord-005941-e4fvj54l	426	24	rejection	rejection	NN
cord-005941-e4fvj54l	426	25	[	[	-LRB-
cord-005941-e4fvj54l	426	26	89	89	CD
cord-005941-e4fvj54l	426	27	]	]	-RRB-
cord-005941-e4fvj54l	426	28	.	.	.
cord-005941-e4fvj54l	427	1	This	this	DT
cord-005941-e4fvj54l	427	2	differential	differential	JJ
cord-005941-e4fvj54l	427	3	diagnosis	diagnosis	NN
cord-005941-e4fvj54l	427	4	represents	represent	VBZ
cord-005941-e4fvj54l	427	5	one	one	CD
cord-005941-e4fvj54l	427	6	of	of	IN
cord-005941-e4fvj54l	427	7	the	the	DT
cord-005941-e4fvj54l	427	8	major	major	JJ
cord-005941-e4fvj54l	427	9	problems	problem	NNS
cord-005941-e4fvj54l	427	10	in	in	IN
cord-005941-e4fvj54l	427	11	the	the	DT
cord-005941-e4fvj54l	427	12	treatment	treatment	NN
cord-005941-e4fvj54l	427	13	of	of	IN
cord-005941-e4fvj54l	427	14	lung	lung	NN
cord-005941-e4fvj54l	427	15	recipients	recipient	NNS
cord-005941-e4fvj54l	427	16	.	.	.
cord-005941-e4fvj54l	428	1	However	however	RB
cord-005941-e4fvj54l	428	2	,	,	,
cord-005941-e4fvj54l	428	3	the	the	DT
cord-005941-e4fvj54l	428	4	data	datum	NNS
cord-005941-e4fvj54l	428	5	obtained	obtain	VBN
cord-005941-e4fvj54l	428	6	in	in	IN
cord-005941-e4fvj54l	428	7	this	this	DT
cord-005941-e4fvj54l	428	8	study	study	NN
cord-005941-e4fvj54l	428	9	were	be	VBD
cord-005941-e4fvj54l	428	10	essentially	essentially	RB
cord-005941-e4fvj54l	428	11	inconclusive	inconclusive	JJ
cord-005941-e4fvj54l	428	12	.	.	.
cord-005941-e4fvj54l	429	1	The	the	DT
cord-005941-e4fvj54l	429	2	optimism	optimism	NN
cord-005941-e4fvj54l	429	3	that	that	IN
cord-005941-e4fvj54l	429	4	surfactant	surfactant	NN
cord-005941-e4fvj54l	429	5	abnormalities	abnormality	NNS
cord-005941-e4fvj54l	429	6	specific	specific	JJ
cord-005941-e4fvj54l	429	7	to	to	IN
cord-005941-e4fvj54l	429	8	rejection	rejection	NN
cord-005941-e4fvj54l	429	9	or	or	CC
cord-005941-e4fvj54l	429	10	infection	infection	NN
cord-005941-e4fvj54l	429	11	will	will	MD
cord-005941-e4fvj54l	429	12	be	be	VB
cord-005941-e4fvj54l	429	13	found	find	VBN
cord-005941-e4fvj54l	429	14	in	in	IN
cord-005941-e4fvj54l	429	15	the	the	DT
cord-005941-e4fvj54l	429	16	future	future	NN
cord-005941-e4fvj54l	429	17	seems	seem	VBZ
cord-005941-e4fvj54l	429	18	somewhat	somewhat	RB
cord-005941-e4fvj54l	429	19	questionable	questionable	JJ
cord-005941-e4fvj54l	429	20	because	because	IN
cord-005941-e4fvj54l	429	21	both	both	DT
cord-005941-e4fvj54l	429	22	are	be	VBP
cord-005941-e4fvj54l	429	23	inflammatory	inflammatory	JJ
cord-005941-e4fvj54l	429	24	processes	process	NNS
cord-005941-e4fvj54l	429	25	with	with	IN
cord-005941-e4fvj54l	429	26	presumably	presumably	RB
cord-005941-e4fvj54l	429	27	similar	similar	JJ
cord-005941-e4fvj54l	429	28	responses	response	NNS
cord-005941-e4fvj54l	429	29	of	of	IN
cord-005941-e4fvj54l	429	30	alveolar	alveolar	JJ
cord-005941-e4fvj54l	429	31	type	type	NN
cord-005941-e4fvj54l	429	32	II	ii	CD
cord-005941-e4fvj54l	429	33	cells	cell	NNS
cord-005941-e4fvj54l	429	34	.	.	.
cord-005941-e4fvj54l	430	1	Another	another	DT
cord-005941-e4fvj54l	430	2	recent	recent	JJ
cord-005941-e4fvj54l	430	3	study	study	NN
cord-005941-e4fvj54l	430	4	[	[	-LRB-
cord-005941-e4fvj54l	430	5	96	96	CD
cord-005941-e4fvj54l	430	6	]	]	-RRB-
cord-005941-e4fvj54l	430	7	determined	determine	VBN
cord-005941-e4fvj54l	430	8	DPPC	DPPC	NNP
cord-005941-e4fvj54l	430	9	levels	level	NNS
cord-005941-e4fvj54l	430	10	in	in	IN
cord-005941-e4fvj54l	430	11	BAL	bal	NN
cord-005941-e4fvj54l	430	12	of	of	IN
cord-005941-e4fvj54l	430	13	excised	excise	VBN
cord-005941-e4fvj54l	430	14	dog	dog	NN
cord-005941-e4fvj54l	430	15	lungs	lung	NNS
cord-005941-e4fvj54l	430	16	during	during	IN
cord-005941-e4fvj54l	430	17	hypothermic	hypothermic	JJ
cord-005941-e4fvj54l	430	18	storage	storage	NN
cord-005941-e4fvj54l	430	19	(	(	-LRB-
cord-005941-e4fvj54l	430	20	4	4	CD
cord-005941-e4fvj54l	430	21	°	°	NN
cord-005941-e4fvj54l	430	22	C	c	NN
cord-005941-e4fvj54l	430	23	for	for	IN
cord-005941-e4fvj54l	430	24	24	24	CD
cord-005941-e4fvj54l	430	25	h	h	NNP
cord-005941-e4fvj54l	430	26	)	)	-RRB-
cord-005941-e4fvj54l	430	27	and	and	CC
cord-005941-e4fvj54l	430	28	after	after	IN
cord-005941-e4fvj54l	430	29	left	left	JJ
cord-005941-e4fvj54l	430	30	lung	lung	NN
cord-005941-e4fvj54l	430	31	transplantation	transplantation	NN
cord-005941-e4fvj54l	430	32	(	(	-LRB-
cord-005941-e4fvj54l	430	33	6	6	CD
cord-005941-e4fvj54l	430	34	dogs	dog	NNS
cord-005941-e4fvj54l	430	35	,	,	,
cord-005941-e4fvj54l	430	36	24-h	24-h	JJ
cord-005941-e4fvj54l	430	37	postoperative	postoperative	JJ
cord-005941-e4fvj54l	430	38	observation	observation	NN
cord-005941-e4fvj54l	430	39	period	period	NN
cord-005941-e4fvj54l	430	40	)	)	-RRB-
cord-005941-e4fvj54l	430	41	.	.	.
cord-005941-e4fvj54l	431	1	A	a	DT
cord-005941-e4fvj54l	431	2	decrease	decrease	NN
cord-005941-e4fvj54l	431	3	of	of	IN
cord-005941-e4fvj54l	431	4	DPPC	DPPC	NNP
cord-005941-e4fvj54l	431	5	levels	level	NNS
cord-005941-e4fvj54l	431	6	was	be	VBD
cord-005941-e4fvj54l	431	7	found	find	VBN
cord-005941-e4fvj54l	431	8	in	in	IN
cord-005941-e4fvj54l	431	9	both	both	DT
cord-005941-e4fvj54l	431	10	situations	situation	NNS
cord-005941-e4fvj54l	431	11	.	.	.
cord-005941-e4fvj54l	432	1	However	however	RB
cord-005941-e4fvj54l	432	2	,	,	,
cord-005941-e4fvj54l	432	3	in	in	IN
cord-005941-e4fvj54l	432	4	a	a	DT
cord-005941-e4fvj54l	432	5	second	second	JJ
cord-005941-e4fvj54l	432	6	group	group	NN
cord-005941-e4fvj54l	432	7	of	of	IN
cord-005941-e4fvj54l	432	8	6	6	CD
cord-005941-e4fvj54l	432	9	transplanted	transplant	VBN
cord-005941-e4fvj54l	432	10	dogs	dog	NNS
cord-005941-e4fvj54l	432	11	receiving	receive	VBG
cord-005941-e4fvj54l	432	12	L	l	NN
cord-005941-e4fvj54l	432	13	-	-	HYPH
cord-005941-e4fvj54l	432	14	carnitine	carnitine	NN
cord-005941-e4fvj54l	432	15	infusions	infusion	NNS
cord-005941-e4fvj54l	433	1	preand	preand	NNP
cord-005941-e4fvj54l	433	2	postoperatively	postoperatively	NNP
cord-005941-e4fvj54l	433	3	,	,	,
cord-005941-e4fvj54l	433	4	DPPC	DPPC	NNP
cord-005941-e4fvj54l	433	5	levels	level	NNS
cord-005941-e4fvj54l	433	6	and	and	CC
cord-005941-e4fvj54l	433	7	oxygen	oxygen	NN
cord-005941-e4fvj54l	433	8	tension	tension	NN
cord-005941-e4fvj54l	433	9	were	be	VBD
cord-005941-e4fvj54l	433	10	higher	high	JJR
cord-005941-e4fvj54l	433	11	postoperatively	postoperatively	RB
cord-005941-e4fvj54l	433	12	than	than	IN
cord-005941-e4fvj54l	433	13	in	in	IN
cord-005941-e4fvj54l	433	14	the	the	DT
cord-005941-e4fvj54l	433	15	group	group	NN
cord-005941-e4fvj54l	433	16	not	not	RB
cord-005941-e4fvj54l	433	17	treated	treat	VBN
cord-005941-e4fvj54l	433	18	with	with	IN
cord-005941-e4fvj54l	433	19	carnitine	carnitine	NN
cord-005941-e4fvj54l	433	20	.	.	.
cord-005941-e4fvj54l	434	1	It	-PRON-	PRP
cord-005941-e4fvj54l	434	2	was	be	VBD
cord-005941-e4fvj54l	434	3	concluded	conclude	VBN
cord-005941-e4fvj54l	434	4	that	that	IN
cord-005941-e4fvj54l	434	5	the	the	DT
cord-005941-e4fvj54l	434	6	drop	drop	NN
cord-005941-e4fvj54l	434	7	in	in	IN
cord-005941-e4fvj54l	434	8	DPPC	DPPC	NNP
cord-005941-e4fvj54l	434	9	levels	level	NNS
cord-005941-e4fvj54l	434	10	reflected	reflect	VBD
cord-005941-e4fvj54l	434	11	ischemic	ischemic	JJ
cord-005941-e4fvj54l	434	12	damage	damage	NN
cord-005941-e4fvj54l	434	13	to	to	IN
cord-005941-e4fvj54l	434	14	alveolar	alveolar	JJ
cord-005941-e4fvj54l	434	15	type	type	NN
cord-005941-e4fvj54l	434	16	II	ii	CD
cord-005941-e4fvj54l	434	17	cells	cell	NNS
cord-005941-e4fvj54l	434	18	and	and	CC
cord-005941-e4fvj54l	434	19	that	that	IN
cord-005941-e4fvj54l	434	20	carnitine	carnitine	NN
cord-005941-e4fvj54l	434	21	(	(	-LRB-
cord-005941-e4fvj54l	434	22	a	a	DT
cord-005941-e4fvj54l	434	23	cofactor	cofactor	NN
cord-005941-e4fvj54l	434	24	for	for	IN
cord-005941-e4fvj54l	434	25	fatty	fatty	JJ
cord-005941-e4fvj54l	434	26	acid	acid	NN
cord-005941-e4fvj54l	434	27	transport	transport	NN
cord-005941-e4fvj54l	434	28	into	into	IN
cord-005941-e4fvj54l	434	29	mitochondria	mitochondrion	NNS
cord-005941-e4fvj54l	434	30	)	)	-RRB-
cord-005941-e4fvj54l	434	31	improved	improve	VBN
cord-005941-e4fvj54l	434	32	surfactant	surfactant	NN
cord-005941-e4fvj54l	434	33	synthesis	synthesis	NN
cord-005941-e4fvj54l	434	34	and	and	CC
cord-005941-e4fvj54l	434	35	therefore	therefore	RB
cord-005941-e4fvj54l	434	36	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	434	37	gas	gas	NN
cord-005941-e4fvj54l	434	38	exchange	exchange	NN
cord-005941-e4fvj54l	434	39	in	in	IN
cord-005941-e4fvj54l	434	40	the	the	DT
cord-005941-e4fvj54l	434	41	transplants	transplant	NNS
cord-005941-e4fvj54l	434	42	.	.	.
cord-005941-e4fvj54l	435	1	However	however	RB
cord-005941-e4fvj54l	435	2	,	,	,
cord-005941-e4fvj54l	435	3	analysis	analysis	NN
cord-005941-e4fvj54l	435	4	of	of	IN
cord-005941-e4fvj54l	435	5	other	other	JJ
cord-005941-e4fvj54l	435	6	BAL	bal	NN
cord-005941-e4fvj54l	435	7	phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	435	8	and	and	CC
cord-005941-e4fvj54l	435	9	surfactant	surfactant	NN
cord-005941-e4fvj54l	435	10	-	-	HYPH
cord-005941-e4fvj54l	435	11	specific	specific	JJ
cord-005941-e4fvj54l	435	12	proteins	protein	NNS
cord-005941-e4fvj54l	435	13	is	be	VBZ
cord-005941-e4fvj54l	435	14	lacking	lack	VBG
cord-005941-e4fvj54l	435	15	in	in	IN
cord-005941-e4fvj54l	435	16	this	this	DT
cord-005941-e4fvj54l	435	17	study	study	NN
cord-005941-e4fvj54l	435	18	,	,	,
cord-005941-e4fvj54l	435	19	and	and	CC
cord-005941-e4fvj54l	435	20	it	-PRON-	PRP
cord-005941-e4fvj54l	435	21	remains	remain	VBZ
cord-005941-e4fvj54l	435	22	to	to	TO
cord-005941-e4fvj54l	435	23	be	be	VB
cord-005941-e4fvj54l	435	24	confirmed	confirm	VBN
cord-005941-e4fvj54l	435	25	that	that	IN
cord-005941-e4fvj54l	435	26	carnitine	carnitine	NN
cord-005941-e4fvj54l	435	27	infusions	infusion	NNS
cord-005941-e4fvj54l	435	28	really	really	RB
cord-005941-e4fvj54l	435	29	have	have	VBP
cord-005941-e4fvj54l	435	30	such	such	JJ
cord-005941-e4fvj54l	435	31	in	in	IN
cord-005941-e4fvj54l	435	32	vivo	vivo	NN
cord-005941-e4fvj54l	435	33	effects	effect	NNS
cord-005941-e4fvj54l	435	34	.	.	.
cord-005941-e4fvj54l	436	1	A	a	DT
cord-005941-e4fvj54l	436	2	current	current	JJ
cord-005941-e4fvj54l	436	3	review	review	NN
cord-005941-e4fvj54l	436	4	of	of	IN
cord-005941-e4fvj54l	436	5	this	this	DT
cord-005941-e4fvj54l	436	6	subject	subject	NN
cord-005941-e4fvj54l	436	7	[	[	-LRB-
cord-005941-e4fvj54l	436	8	128	128	CD
cord-005941-e4fvj54l	436	9	]	]	-RRB-
cord-005941-e4fvj54l	436	10	outlines	outline	VBZ
cord-005941-e4fvj54l	436	11	some	some	DT
cord-005941-e4fvj54l	436	12	of	of	IN
cord-005941-e4fvj54l	436	13	the	the	DT
cord-005941-e4fvj54l	436	14	possible	possible	JJ
cord-005941-e4fvj54l	436	15	perspectives	perspective	NNS
cord-005941-e4fvj54l	436	16	of	of	IN
cord-005941-e4fvj54l	436	17	surfactant	surfactant	NN
cord-005941-e4fvj54l	436	18	analysis	analysis	NN
cord-005941-e4fvj54l	436	19	and	and	CC
cord-005941-e4fvj54l	436	20	treatment	treatment	NN
cord-005941-e4fvj54l	436	21	in	in	IN
cord-005941-e4fvj54l	436	22	lung	lung	NN
cord-005941-e4fvj54l	436	23	transplantation	transplantation	NN
cord-005941-e4fvj54l	436	24	in	in	IN
cord-005941-e4fvj54l	436	25	more	more	JJR
cord-005941-e4fvj54l	436	26	detail	detail	NN
cord-005941-e4fvj54l	436	27	.	.	.
cord-005941-e4fvj54l	437	1	Certainly	certainly	RB
cord-005941-e4fvj54l	437	2	,	,	,
cord-005941-e4fvj54l	437	3	much	much	RB
cord-005941-e4fvj54l	437	4	more	more	JJR
cord-005941-e4fvj54l	437	5	work	work	NN
cord-005941-e4fvj54l	437	6	has	have	VBZ
cord-005941-e4fvj54l	437	7	to	to	TO
cord-005941-e4fvj54l	437	8	be	be	VB
cord-005941-e4fvj54l	437	9	done	do	VBN
cord-005941-e4fvj54l	437	10	to	to	TO
cord-005941-e4fvj54l	437	11	assess	assess	VB
cord-005941-e4fvj54l	437	12	the	the	DT
cord-005941-e4fvj54l	437	13	usefulness	usefulness	NN
cord-005941-e4fvj54l	437	14	of	of	IN
cord-005941-e4fvj54l	437	15	surfactant	surfactant	NN
cord-005941-e4fvj54l	437	16	studies	study	NNS
cord-005941-e4fvj54l	437	17	or	or	CC
cord-005941-e4fvj54l	437	18	even	even	RB
cord-005941-e4fvj54l	437	19	surfactant	surfactant	NN
cord-005941-e4fvj54l	437	20	replacement	replacement	NN
cord-005941-e4fvj54l	437	21	therapies	therapy	NNS
cord-005941-e4fvj54l	437	22	in	in	IN
cord-005941-e4fvj54l	437	23	lung	lung	NN
cord-005941-e4fvj54l	437	24	recipients	recipient	NNS
cord-005941-e4fvj54l	437	25	.	.	.
cord-005941-e4fvj54l	438	1	As	as	IN
cord-005941-e4fvj54l	438	2	outlined	outline	VBN
cord-005941-e4fvj54l	438	3	before	before	RB
cord-005941-e4fvj54l	438	4	,	,	,
cord-005941-e4fvj54l	438	5	surfactant	surfactant	NN
cord-005941-e4fvj54l	438	6	therapy	therapy	NN
cord-005941-e4fvj54l	438	7	may	may	MD
cord-005941-e4fvj54l	438	8	prove	prove	VB
cord-005941-e4fvj54l	438	9	to	to	TO
cord-005941-e4fvj54l	438	10	have	have	VB
cord-005941-e4fvj54l	438	11	beneficial	beneficial	JJ
cord-005941-e4fvj54l	438	12	effects	effect	NNS
cord-005941-e4fvj54l	438	13	on	on	IN
cord-005941-e4fvj54l	438	14	the	the	DT
cord-005941-e4fvj54l	438	15	course	course	NN
cord-005941-e4fvj54l	438	16	of	of	IN
cord-005941-e4fvj54l	438	17	ARDS	ARDS	NNP
cord-005941-e4fvj54l	438	18	and	and	CC
cord-005941-e4fvj54l	438	19	is	be	VBZ
cord-005941-e4fvj54l	438	20	now	now	RB
cord-005941-e4fvj54l	438	21	being	be	VBG
cord-005941-e4fvj54l	438	22	investigated	investigate	VBN
cord-005941-e4fvj54l	438	23	in	in	IN
cord-005941-e4fvj54l	438	24	clinical	clinical	JJ
cord-005941-e4fvj54l	438	25	trials	trial	NNS
cord-005941-e4fvj54l	438	26	.	.	.
cord-005941-e4fvj54l	439	1	Presently	presently	RB
cord-005941-e4fvj54l	439	2	,	,	,
cord-005941-e4fvj54l	439	3	there	there	EX
cord-005941-e4fvj54l	439	4	is	be	VBZ
cord-005941-e4fvj54l	439	5	no	no	DT
cord-005941-e4fvj54l	439	6	convincing	convincing	JJ
cord-005941-e4fvj54l	439	7	evidence	evidence	NN
cord-005941-e4fvj54l	439	8	to	to	TO
cord-005941-e4fvj54l	439	9	suggest	suggest	VB
cord-005941-e4fvj54l	439	10	that	that	IN
cord-005941-e4fvj54l	439	11	such	such	PDT
cord-005941-e4fvj54l	439	12	a	a	DT
cord-005941-e4fvj54l	439	13	treatment	treatment	NN
cord-005941-e4fvj54l	439	14	may	may	MD
cord-005941-e4fvj54l	439	15	also	also	RB
cord-005941-e4fvj54l	439	16	be	be	VB
cord-005941-e4fvj54l	439	17	of	of	IN
cord-005941-e4fvj54l	439	18	use	use	NN
cord-005941-e4fvj54l	439	19	in	in	IN
cord-005941-e4fvj54l	439	20	other	other	JJ
cord-005941-e4fvj54l	439	21	adult	adult	NN
cord-005941-e4fvj54l	439	22	lung	lung	NN
cord-005941-e4fvj54l	439	23	diseases	disease	NNS
cord-005941-e4fvj54l	439	24	.	.	.
cord-005941-e4fvj54l	440	1	A	a	DT
cord-005941-e4fvj54l	440	2	number	number	NN
cord-005941-e4fvj54l	440	3	of	of	IN
cord-005941-e4fvj54l	440	4	surfactant	surfactant	NN
cord-005941-e4fvj54l	440	5	preparations	preparation	NNS
cord-005941-e4fvj54l	440	6	are	be	VBP
cord-005941-e4fvj54l	440	7	now	now	RB
cord-005941-e4fvj54l	440	8	in	in	IN
cord-005941-e4fvj54l	440	9	use	use	NN
cord-005941-e4fvj54l	440	10	,	,	,
cord-005941-e4fvj54l	440	11	and	and	CC
cord-005941-e4fvj54l	440	12	some	some	DT
cord-005941-e4fvj54l	440	13	of	of	IN
cord-005941-e4fvj54l	440	14	them	-PRON-	PRP
cord-005941-e4fvj54l	440	15	are	be	VBP
cord-005941-e4fvj54l	440	16	already	already	RB
cord-005941-e4fvj54l	440	17	marketed	market	VBN
cord-005941-e4fvj54l	440	18	for	for	IN
cord-005941-e4fvj54l	440	19	the	the	DT
cord-005941-e4fvj54l	440	20	treatment	treatment	NN
cord-005941-e4fvj54l	440	21	of	of	IN
cord-005941-e4fvj54l	440	22	IRDS	IRDS	NNP
cord-005941-e4fvj54l	440	23	.	.	.
cord-005941-e4fvj54l	441	1	Their	-PRON-	PRP$
cord-005941-e4fvj54l	441	2	composition	composition	NN
cord-005941-e4fvj54l	441	3	and	and	CC
cord-005941-e4fvj54l	441	4	therefore	therefore	RB
cord-005941-e4fvj54l	441	5	their	-PRON-	PRP$
cord-005941-e4fvj54l	441	6	properties	property	NNS
cord-005941-e4fvj54l	441	7	vary	vary	VBP
cord-005941-e4fvj54l	441	8	considerably	considerably	RB
cord-005941-e4fvj54l	441	9	,	,	,
cord-005941-e4fvj54l	441	10	and	and	CC
cord-005941-e4fvj54l	441	11	it	-PRON-	PRP
cord-005941-e4fvj54l	441	12	is	be	VBZ
cord-005941-e4fvj54l	441	13	not	not	RB
cord-005941-e4fvj54l	441	14	yet	yet	RB
cord-005941-e4fvj54l	441	15	clear	clear	JJ
cord-005941-e4fvj54l	441	16	which	which	WDT
cord-005941-e4fvj54l	441	17	preparation	preparation	NN
cord-005941-e4fvj54l	441	18	will	will	MD
cord-005941-e4fvj54l	441	19	be	be	VB
cord-005941-e4fvj54l	441	20	the	the	DT
cord-005941-e4fvj54l	441	21	best	well	RBS
cord-005941-e4fvj54l	441	22	considering	considering	JJ
cord-005941-e4fvj54l	441	23	efficacy	efficacy	NN
cord-005941-e4fvj54l	441	24	,	,	,
cord-005941-e4fvj54l	441	25	safety	safety	NN
cord-005941-e4fvj54l	441	26	,	,	,
cord-005941-e4fvj54l	441	27	availability	availability	NN
cord-005941-e4fvj54l	441	28	,	,	,
cord-005941-e4fvj54l	441	29	and	and	CC
cord-005941-e4fvj54l	441	30	price	price	NN
cord-005941-e4fvj54l	441	31	.	.	.
cord-005941-e4fvj54l	442	1	It	-PRON-	PRP
cord-005941-e4fvj54l	442	2	seems	seem	VBZ
cord-005941-e4fvj54l	442	3	possible	possible	JJ
cord-005941-e4fvj54l	442	4	that	that	IN
cord-005941-e4fvj54l	442	5	different	different	JJ
cord-005941-e4fvj54l	442	6	surfactants	surfactant	NNS
cord-005941-e4fvj54l	442	7	will	will	MD
cord-005941-e4fvj54l	442	8	in	in	IN
cord-005941-e4fvj54l	442	9	the	the	DT
cord-005941-e4fvj54l	442	10	future	future	NN
cord-005941-e4fvj54l	442	11	prove	prove	VB
cord-005941-e4fvj54l	442	12	optimal	optimal	JJ
cord-005941-e4fvj54l	442	13	for	for	IN
cord-005941-e4fvj54l	442	14	different	different	JJ
cord-005941-e4fvj54l	442	15	indications	indication	NNS
cord-005941-e4fvj54l	442	16	,	,	,
cord-005941-e4fvj54l	442	17	thus	thus	RB
cord-005941-e4fvj54l	442	18	perhaps	perhaps	RB
cord-005941-e4fvj54l	442	19	leading	lead	VBG
cord-005941-e4fvj54l	442	20	to	to	IN
cord-005941-e4fvj54l	442	21	a	a	DT
cord-005941-e4fvj54l	442	22	variety	variety	NN
cord-005941-e4fvj54l	442	23	of	of	IN
cord-005941-e4fvj54l	442	24	specifically	specifically	RB
cord-005941-e4fvj54l	442	25	designed	design	VBN
cord-005941-e4fvj54l	442	26	preparations	preparation	NNS
cord-005941-e4fvj54l	442	27	.	.	.
cord-005941-e4fvj54l	443	1	Bovine	bovine	JJ
cord-005941-e4fvj54l	443	2	surfactant	surfactant	NN
cord-005941-e4fvj54l	443	3	preparations	preparation	NNS
cord-005941-e4fvj54l	443	4	(	(	-LRB-
cord-005941-e4fvj54l	443	5	e.g.	e.g.	RB
cord-005941-e4fvj54l	443	6	,	,	,
cord-005941-e4fvj54l	443	7	Survanta	Survanta	NNP
cord-005941-e4fvj54l	443	8	,	,	,
cord-005941-e4fvj54l	443	9	Surfactant	Surfactant	NNP
cord-005941-e4fvj54l	443	10	-	-	HYPH
cord-005941-e4fvj54l	443	11	TA	TA	NNP
cord-005941-e4fvj54l	443	12	,	,	,
cord-005941-e4fvj54l	443	13	Alveofact	Alveofact	NNP
cord-005941-e4fvj54l	443	14	)	)	-RRB-
cord-005941-e4fvj54l	443	15	are	be	VBP
cord-005941-e4fvj54l	443	16	organic	organic	JJ
cord-005941-e4fvj54l	443	17	solvent	solvent	NN
cord-005941-e4fvj54l	443	18	extracts	extract	NNS
cord-005941-e4fvj54l	443	19	of	of	IN
cord-005941-e4fvj54l	443	20	minced	mince	VBN
cord-005941-e4fvj54l	443	21	cow	cow	NN
cord-005941-e4fvj54l	443	22	lungs	lung	NNS
cord-005941-e4fvj54l	443	23	and	and	CC
cord-005941-e4fvj54l	443	24	contain	contain	VBP
cord-005941-e4fvj54l	443	25	phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	443	26	in	in	IN
cord-005941-e4fvj54l	443	27	a	a	DT
cord-005941-e4fvj54l	443	28	natural	natural	JJ
cord-005941-e4fvj54l	443	29	composition	composition	NN
cord-005941-e4fvj54l	443	30	plus	plus	IN
cord-005941-e4fvj54l	443	31	SP	SP	NNP
cord-005941-e4fvj54l	443	32	-	-	HYPH
cord-005941-e4fvj54l	443	33	B	B	NNP
cord-005941-e4fvj54l	443	34	and	and	CC
cord-005941-e4fvj54l	443	35	SP	SP	NNP
cord-005941-e4fvj54l	443	36	-	-	HYPH
cord-005941-e4fvj54l	443	37	C	C	NNP
cord-005941-e4fvj54l	443	38	but	but	CC
cord-005941-e4fvj54l	443	39	no	no	DT
cord-005941-e4fvj54l	443	40	SP	sp	NN
cord-005941-e4fvj54l	443	41	-	-	HYPH
cord-005941-e4fvj54l	443	42	A.	a.	NN
cord-005941-e4fvj54l	444	1	In	in	IN
cord-005941-e4fvj54l	444	2	a	a	DT
cord-005941-e4fvj54l	444	3	randomized	randomized	JJ
cord-005941-e4fvj54l	444	4	controlled	control	VBN
cord-005941-e4fvj54l	444	5	trial	trial	NN
cord-005941-e4fvj54l	444	6	of	of	IN
cord-005941-e4fvj54l	444	7	a	a	DT
cord-005941-e4fvj54l	444	8	bovine	bovine	JJ
cord-005941-e4fvj54l	444	9	surfactant	surfactant	NN
cord-005941-e4fvj54l	444	10	preparation	preparation	NN
cord-005941-e4fvj54l	444	11	(	(	-LRB-
cord-005941-e4fvj54l	444	12	single	single	JJ
cord-005941-e4fvj54l	444	13	dose	dose	NN
cord-005941-e4fvj54l	444	14	)	)	-RRB-
cord-005941-e4fvj54l	444	15	for	for	IN
cord-005941-e4fvj54l	444	16	the	the	DT
cord-005941-e4fvj54l	444	17	prevention	prevention	NN
cord-005941-e4fvj54l	444	18	of	of	IN
cord-005941-e4fvj54l	444	19	IRDS	IRDS	NNP
cord-005941-e4fvj54l	444	20	[	[	-LRB-
cord-005941-e4fvj54l	444	21	51	51	CD
cord-005941-e4fvj54l	444	22	]	]	-RRB-
cord-005941-e4fvj54l	444	23	,	,	,
cord-005941-e4fvj54l	444	24	it	-PRON-	PRP
cord-005941-e4fvj54l	444	25	could	could	MD
cord-005941-e4fvj54l	444	26	be	be	VB
cord-005941-e4fvj54l	444	27	demon-651	demon-651	NNP
cord-005941-e4fvj54l	444	28	strated	strate	VBN
cord-005941-e4fvj54l	444	29	that	that	IN
cord-005941-e4fvj54l	444	30	the	the	DT
cord-005941-e4fvj54l	444	31	survival	survival	NN
cord-005941-e4fvj54l	444	32	rate	rate	NN
cord-005941-e4fvj54l	444	33	without	without	IN
cord-005941-e4fvj54l	444	34	bronchopulmonary	bronchopulmonary	NNP
cord-005941-e4fvj54l	444	35	dysplasia	dysplasia	NNP
cord-005941-e4fvj54l	444	36	was	be	VBD
cord-005941-e4fvj54l	444	37	significantly	significantly	RB
cord-005941-e4fvj54l	444	38	improved	improve	VBN
cord-005941-e4fvj54l	444	39	.	.	.
cord-005941-e4fvj54l	445	1	Furthermore	furthermore	RB
cord-005941-e4fvj54l	445	2	,	,	,
cord-005941-e4fvj54l	445	3	there	there	EX
cord-005941-e4fvj54l	445	4	was	be	VBD
cord-005941-e4fvj54l	445	5	a	a	DT
cord-005941-e4fvj54l	445	6	tendency	tendency	NN
cord-005941-e4fvj54l	445	7	to	to	IN
cord-005941-e4fvj54l	445	8	a	a	DT
cord-005941-e4fvj54l	445	9	better	well	JJR
cord-005941-e4fvj54l	445	10	overall	overall	JJ
cord-005941-e4fvj54l	445	11	survival	survival	NN
cord-005941-e4fvj54l	445	12	rate	rate	NN
cord-005941-e4fvj54l	445	13	and	and	CC
cord-005941-e4fvj54l	445	14	a	a	DT
cord-005941-e4fvj54l	445	15	reduction	reduction	NN
cord-005941-e4fvj54l	445	16	in	in	IN
cord-005941-e4fvj54l	445	17	total	total	JJ
cord-005941-e4fvj54l	445	18	time	time	NN
cord-005941-e4fvj54l	445	19	of	of	IN
cord-005941-e4fvj54l	445	20	mechanical	mechanical	JJ
cord-005941-e4fvj54l	445	21	ventilation	ventilation	NN
cord-005941-e4fvj54l	445	22	.	.	.
cord-005941-e4fvj54l	446	1	A	a	DT
cord-005941-e4fvj54l	446	2	single	single	JJ
cord-005941-e4fvj54l	446	3	-	-	HYPH
cord-005941-e4fvj54l	446	4	dose	dose	NN
cord-005941-e4fvj54l	446	5	regimen	regimen	NN
cord-005941-e4fvj54l	446	6	of	of	IN
cord-005941-e4fvj54l	446	7	Survanta	Survanta	NNP
cord-005941-e4fvj54l	446	8	reduced	reduce	VBD
cord-005941-e4fvj54l	446	9	the	the	DT
cord-005941-e4fvj54l	446	10	severity	severity	NN
cord-005941-e4fvj54l	446	11	of	of	IN
cord-005941-e4fvj54l	446	12	respiratory	respiratory	JJ
cord-005941-e4fvj54l	446	13	distress	distress	NN
cord-005941-e4fvj54l	446	14	and	and	CC
cord-005941-e4fvj54l	446	15	the	the	DT
cord-005941-e4fvj54l	446	16	frequency	frequency	NN
cord-005941-e4fvj54l	446	17	of	of	IN
cord-005941-e4fvj54l	446	18	pneumothorax	pneumothorax	NN
cord-005941-e4fvj54l	446	19	but	but	CC
cord-005941-e4fvj54l	446	20	not	not	RB
cord-005941-e4fvj54l	446	21	the	the	DT
cord-005941-e4fvj54l	446	22	mortality	mortality	NN
cord-005941-e4fvj54l	446	23	in	in	IN
cord-005941-e4fvj54l	446	24	another	another	DT
cord-005941-e4fvj54l	446	25	randomized	randomized	JJ
cord-005941-e4fvj54l	446	26	controlled	control	VBN
cord-005941-e4fvj54l	446	27	study	study	NN
cord-005941-e4fvj54l	446	28	of	of	IN
cord-005941-e4fvj54l	446	29	IRDS	IRDS	NNP
cord-005941-e4fvj54l	446	30	[	[	-LRB-
cord-005941-e4fvj54l	446	31	79	79	CD
cord-005941-e4fvj54l	446	32	]	]	-RRB-
cord-005941-e4fvj54l	446	33	.	.	.
cord-005941-e4fvj54l	447	1	Survanta	Survanta	NNP
cord-005941-e4fvj54l	447	2	has	have	VBZ
cord-005941-e4fvj54l	447	3	also	also	RB
cord-005941-e4fvj54l	447	4	been	be	VBN
cord-005941-e4fvj54l	447	5	reported	report	VBN
cord-005941-e4fvj54l	447	6	to	to	TO
cord-005941-e4fvj54l	447	7	improve	improve	VB
cord-005941-e4fvj54l	447	8	lung	lung	NN
cord-005941-e4fvj54l	447	9	recoil	recoil	NN
cord-005941-e4fvj54l	447	10	but	but	CC
cord-005941-e4fvj54l	447	11	not	not	RB
cord-005941-e4fvj54l	447	12	arterial	arterial	JJ
cord-005941-e4fvj54l	447	13	blood	blood	NN
cord-005941-e4fvj54l	447	14	gases	gas	NNS
cord-005941-e4fvj54l	447	15	in	in	IN
cord-005941-e4fvj54l	447	16	a	a	DT
cord-005941-e4fvj54l	447	17	rabbit	rabbit	NN
cord-005941-e4fvj54l	447	18	lung	lung	NN
cord-005941-e4fvj54l	447	19	model	model	NN
cord-005941-e4fvj54l	447	20	of	of	IN
cord-005941-e4fvj54l	447	21	ARDS	ARDS	NNP
cord-005941-e4fvj54l	447	22	[	[	-LRB-
cord-005941-e4fvj54l	447	23	101	101	CD
cord-005941-e4fvj54l	447	24	]	]	-RRB-
cord-005941-e4fvj54l	447	25	.	.	.
cord-005941-e4fvj54l	448	1	Surfactant	surfactant	NN
cord-005941-e4fvj54l	448	2	-	-	HYPH
cord-005941-e4fvj54l	448	3	TA	TA	NNP
cord-005941-e4fvj54l	448	4	in	in	IN
cord-005941-e4fvj54l	448	5	a	a	DT
cord-005941-e4fvj54l	448	6	randomized	randomized	JJ
cord-005941-e4fvj54l	448	7	controlled	control	VBN
cord-005941-e4fvj54l	448	8	trial	trial	NN
cord-005941-e4fvj54l	448	9	has	have	VBZ
cord-005941-e4fvj54l	448	10	been	be	VBN
cord-005941-e4fvj54l	448	11	shown	show	VBN
cord-005941-e4fvj54l	448	12	to	to	TO
cord-005941-e4fvj54l	448	13	diminish	diminish	VB
cord-005941-e4fvj54l	448	14	the	the	DT
cord-005941-e4fvj54l	448	15	amount	amount	NN
cord-005941-e4fvj54l	448	16	of	of	IN
cord-005941-e4fvj54l	448	17	respiratory	respiratory	JJ
cord-005941-e4fvj54l	448	18	support	support	NN
cord-005941-e4fvj54l	448	19	necessary	necessary	JJ
cord-005941-e4fvj54l	448	20	in	in	IN
cord-005941-e4fvj54l	448	21	premature	premature	JJ
cord-005941-e4fvj54l	448	22	infants	infant	NNS
cord-005941-e4fvj54l	448	23	with	with	IN
cord-005941-e4fvj54l	448	24	IRDS	IRDS	NNP
cord-005941-e4fvj54l	448	25	[	[	-LRB-
cord-005941-e4fvj54l	448	26	49	49	CD
cord-005941-e4fvj54l	448	27	]	]	-RRB-
cord-005941-e4fvj54l	448	28	.	.	.
cord-005941-e4fvj54l	449	1	Another	another	DT
cord-005941-e4fvj54l	449	2	similar	similar	JJ
cord-005941-e4fvj54l	449	3	study	study	NN
cord-005941-e4fvj54l	449	4	demonstrated	demonstrate	VBD
cord-005941-e4fvj54l	449	5	the	the	DT
cord-005941-e4fvj54l	449	6	reduction	reduction	NN
cord-005941-e4fvj54l	449	7	of	of	IN
cord-005941-e4fvj54l	449	8	intracranial	intracranial	JJ
cord-005941-e4fvj54l	449	9	hemorrhage	hemorrhage	NN
cord-005941-e4fvj54l	449	10	and	and	CC
cord-005941-e4fvj54l	449	11	bronchopulmonary	bronchopulmonary	JJ
cord-005941-e4fvj54l	449	12	dysplasia	dysplasia	NN
cord-005941-e4fvj54l	449	13	in	in	IN
cord-005941-e4fvj54l	449	14	infants	infant	NNS
cord-005941-e4fvj54l	449	15	surviving	survive	VBG
cord-005941-e4fvj54l	449	16	IRDS	IRDS	NNP
cord-005941-e4fvj54l	449	17	[	[	-LRB-
cord-005941-e4fvj54l	449	18	47	47	CD
cord-005941-e4fvj54l	449	19	]	]	-RRB-
cord-005941-e4fvj54l	449	20	.	.	.
cord-005941-e4fvj54l	450	1	In	in	IN
cord-005941-e4fvj54l	450	2	an	an	DT
cord-005941-e4fvj54l	450	3	anecdotal	anecdotal	JJ
cord-005941-e4fvj54l	450	4	report	report	NN
cord-005941-e4fvj54l	450	5	of	of	IN
cord-005941-e4fvj54l	450	6	2	2	CD
cord-005941-e4fvj54l	450	7	cases	case	NNS
cord-005941-e4fvj54l	450	8	of	of	IN
cord-005941-e4fvj54l	450	9	ARDS	ARDS	NNP
cord-005941-e4fvj54l	450	10	,	,	,
cord-005941-e4fvj54l	450	11	Surfactant	Surfactant	NNP
cord-005941-e4fvj54l	450	12	-	-	HYPH
cord-005941-e4fvj54l	450	13	TA	TA	NNP
cord-005941-e4fvj54l	450	14	was	be	VBD
cord-005941-e4fvj54l	450	15	also	also	RB
cord-005941-e4fvj54l	450	16	reported	report	VBN
cord-005941-e4fvj54l	450	17	to	to	TO
cord-005941-e4fvj54l	450	18	have	have	VB
cord-005941-e4fvj54l	450	19	beneficial	beneficial	JJ
cord-005941-e4fvj54l	450	20	effects	effect	NNS
cord-005941-e4fvj54l	450	21	,	,	,
cord-005941-e4fvj54l	450	22	although	although	IN
cord-005941-e4fvj54l	450	23	the	the	DT
cord-005941-e4fvj54l	450	24	dose	dose	NN
cord-005941-e4fvj54l	450	25	was	be	VBD
cord-005941-e4fvj54l	450	26	unusually	unusually	RB
cord-005941-e4fvj54l	450	27	low	low	JJ
cord-005941-e4fvj54l	450	28	[	[	-LRB-
cord-005941-e4fvj54l	450	29	127	127	CD
cord-005941-e4fvj54l	450	30	]	]	-RRB-
cord-005941-e4fvj54l	450	31	.	.	.
cord-005941-e4fvj54l	451	1	Porcine	porcine	JJ
cord-005941-e4fvj54l	451	2	surfactants	surfactant	NNS
cord-005941-e4fvj54l	451	3	(	(	-LRB-
cord-005941-e4fvj54l	451	4	e.g.	e.g.	RB
cord-005941-e4fvj54l	451	5	,	,	,
cord-005941-e4fvj54l	451	6	Curosurf	Curosurf	NNP
cord-005941-e4fvj54l	451	7	)	)	-RRB-
cord-005941-e4fvj54l	451	8	are	be	VBP
cord-005941-e4fvj54l	451	9	organic	organic	JJ
cord-005941-e4fvj54l	451	10	solvent	solvent	NN
cord-005941-e4fvj54l	451	11	extracts	extract	NNS
cord-005941-e4fvj54l	451	12	from	from	IN
cord-005941-e4fvj54l	451	13	minced	mince	VBN
cord-005941-e4fvj54l	451	14	porcine	porcine	JJ
cord-005941-e4fvj54l	451	15	lungs	lung	NNS
cord-005941-e4fvj54l	451	16	with	with	IN
cord-005941-e4fvj54l	451	17	a	a	DT
cord-005941-e4fvj54l	451	18	composition	composition	NN
cord-005941-e4fvj54l	451	19	comparable	comparable	JJ
cord-005941-e4fvj54l	451	20	to	to	IN
cord-005941-e4fvj54l	451	21	bovine	bovine	JJ
cord-005941-e4fvj54l	451	22	surfactants	surfactant	NNS
cord-005941-e4fvj54l	451	23	.	.	.
cord-005941-e4fvj54l	452	1	Beneficial	beneficial	JJ
cord-005941-e4fvj54l	452	2	effects	effect	NNS
cord-005941-e4fvj54l	452	3	of	of	IN
cord-005941-e4fvj54l	452	4	Curosurf	Curosurf	NNP
cord-005941-e4fvj54l	452	5	have	have	VBP
cord-005941-e4fvj54l	452	6	been	be	VBN
cord-005941-e4fvj54l	452	7	described	describe	VBN
cord-005941-e4fvj54l	452	8	in	in	IN
cord-005941-e4fvj54l	452	9	3	3	CD
cord-005941-e4fvj54l	452	10	patients	patient	NNS
cord-005941-e4fvj54l	452	11	with	with	IN
cord-005941-e4fvj54l	452	12	ARDS	ARDS	NNP
cord-005941-e4fvj54l	452	13	[	[	-LRB-
cord-005941-e4fvj54l	452	14	152	152	CD
cord-005941-e4fvj54l	452	15	]	]	-RRB-
cord-005941-e4fvj54l	452	16	and	and	CC
cord-005941-e4fvj54l	452	17	in	in	IN
cord-005941-e4fvj54l	452	18	a	a	DT
cord-005941-e4fvj54l	452	19	series	series	NN
cord-005941-e4fvj54l	452	20	of	of	IN
cord-005941-e4fvj54l	452	21	children	child	NNS
cord-005941-e4fvj54l	452	22	with	with	IN
cord-005941-e4fvj54l	452	23	severe	severe	JJ
cord-005941-e4fvj54l	452	24	IRDS	irds	NN
cord-005941-e4fvj54l	452	25	[	[	-LRB-
cord-005941-e4fvj54l	452	26	166	166	CD
cord-005941-e4fvj54l	452	27	]	]	-RRB-
cord-005941-e4fvj54l	452	28	.	.	.
cord-005941-e4fvj54l	453	1	Also	also	RB
cord-005941-e4fvj54l	453	2	,	,	,
cord-005941-e4fvj54l	453	3	natural	natural	JJ
cord-005941-e4fvj54l	453	4	surfactants	surfactant	NNS
cord-005941-e4fvj54l	453	5	from	from	IN
cord-005941-e4fvj54l	453	6	amnion	amnion	NN
cord-005941-e4fvj54l	453	7	fluid	fluid	NN
cord-005941-e4fvj54l	453	8	or	or	CC
cord-005941-e4fvj54l	453	9	BAL	bal	NN
cord-005941-e4fvj54l	453	10	have	have	VBP
cord-005941-e4fvj54l	453	11	been	be	VBN
cord-005941-e4fvj54l	453	12	used	use	VBN
cord-005941-e4fvj54l	453	13	.	.	.
cord-005941-e4fvj54l	454	1	A	a	DT
cord-005941-e4fvj54l	454	2	serious	serious	JJ
cord-005941-e4fvj54l	454	3	drawback	drawback	NN
cord-005941-e4fvj54l	454	4	of	of	IN
cord-005941-e4fvj54l	454	5	all	all	DT
cord-005941-e4fvj54l	454	6	natural	natural	JJ
cord-005941-e4fvj54l	454	7	surfactants	surfactant	NNS
cord-005941-e4fvj54l	454	8	is	be	VBZ
cord-005941-e4fvj54l	454	9	their	-PRON-	PRP$
cord-005941-e4fvj54l	454	10	limited	limit	VBN
cord-005941-e4fvj54l	454	11	availability	availability	NN
cord-005941-e4fvj54l	454	12	and	and	CC
cord-005941-e4fvj54l	454	13	their	-PRON-	PRP$
cord-005941-e4fvj54l	454	14	high	high	JJ
cord-005941-e4fvj54l	454	15	prices	price	NNS
cord-005941-e4fvj54l	454	16	.	.	.
cord-005941-e4fvj54l	455	1	ALEC	ALEC	NNP
cord-005941-e4fvj54l	455	2	is	be	VBZ
cord-005941-e4fvj54l	455	3	a	a	DT
cord-005941-e4fvj54l	455	4	simple	simple	JJ
cord-005941-e4fvj54l	455	5	preparation	preparation	NN
cord-005941-e4fvj54l	455	6	of	of	IN
cord-005941-e4fvj54l	455	7	only	only	RB
cord-005941-e4fvj54l	455	8	two	two	CD
cord-005941-e4fvj54l	455	9	phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	455	10	,	,	,
cord-005941-e4fvj54l	455	11	DPPC	DPPC	NNP
cord-005941-e4fvj54l	455	12	and	and	CC
cord-005941-e4fvj54l	455	13	PG	PG	NNP
cord-005941-e4fvj54l	455	14	(	(	-LRB-
cord-005941-e4fvj54l	455	15	in	in	IN
cord-005941-e4fvj54l	455	16	a	a	DT
cord-005941-e4fvj54l	455	17	weight	weight	NN
cord-005941-e4fvj54l	455	18	proportion	proportion	NN
cord-005941-e4fvj54l	455	19	of	of	IN
cord-005941-e4fvj54l	455	20	7:3	7:3	CD
cord-005941-e4fvj54l	455	21	)	)	-RRB-
cord-005941-e4fvj54l	455	22	.	.	.
cord-005941-e4fvj54l	456	1	Exosurf	Exosurf	NNP
cord-005941-e4fvj54l	456	2	(	(	-LRB-
cord-005941-e4fvj54l	456	3	or	or	CC
cord-005941-e4fvj54l	456	4	Exosurf	Exosurf	NNP
cord-005941-e4fvj54l	456	5	Neonatal	Neonatal	NNP
cord-005941-e4fvj54l	456	6	)	)	-RRB-
cord-005941-e4fvj54l	456	7	is	be	VBZ
cord-005941-e4fvj54l	456	8	a	a	DT
cord-005941-e4fvj54l	456	9	mixture	mixture	NN
cord-005941-e4fvj54l	456	10	of	of	IN
cord-005941-e4fvj54l	456	11	DPPC	DPPC	NNP
cord-005941-e4fvj54l	456	12	,	,	,
cord-005941-e4fvj54l	456	13	hexadecanol	hexadecanol	NN
cord-005941-e4fvj54l	456	14	,	,	,
cord-005941-e4fvj54l	456	15	and	and	CC
cord-005941-e4fvj54l	456	16	tyloxapol	tyloxapol	NN
cord-005941-e4fvj54l	456	17	and	and	CC
cord-005941-e4fvj54l	456	18	also	also	RB
cord-005941-e4fvj54l	456	19	does	do	VBZ
cord-005941-e4fvj54l	456	20	not	not	RB
cord-005941-e4fvj54l	456	21	contain	contain	VB
cord-005941-e4fvj54l	456	22	surfactant	surfactant	NN
cord-005941-e4fvj54l	456	23	-	-	HYPH
cord-005941-e4fvj54l	456	24	specific	specific	JJ
cord-005941-e4fvj54l	456	25	proteins	protein	NNS
cord-005941-e4fvj54l	456	26	.	.	.
cord-005941-e4fvj54l	457	1	In	in	IN
cord-005941-e4fvj54l	457	2	a	a	DT
cord-005941-e4fvj54l	457	3	recently	recently	RB
cord-005941-e4fvj54l	457	4	published	publish	VBN
cord-005941-e4fvj54l	457	5	,	,	,
cord-005941-e4fvj54l	457	6	large	large	JJ
cord-005941-e4fvj54l	457	7	,	,	,
cord-005941-e4fvj54l	457	8	multicenter	multicenter	JJ
cord-005941-e4fvj54l	457	9	trial	trial	NN
cord-005941-e4fvj54l	457	10	in	in	IN
cord-005941-e4fvj54l	457	11	infants	infant	NNS
cord-005941-e4fvj54l	457	12	with	with	IN
cord-005941-e4fvj54l	457	13	IRDS	IRDS	NNP
cord-005941-e4fvj54l	457	14	[	[	-LRB-
cord-005941-e4fvj54l	457	15	106	106	CD
cord-005941-e4fvj54l	457	16	]	]	-RRB-
cord-005941-e4fvj54l	457	17	,	,	,
cord-005941-e4fvj54l	457	18	Exosurf	Exosurf	NNP
cord-005941-e4fvj54l	457	19	in	in	IN
cord-005941-e4fvj54l	457	20	a	a	DT
cord-005941-e4fvj54l	457	21	two	two	CD
cord-005941-e4fvj54l	457	22	-	-	HYPH
cord-005941-e4fvj54l	457	23	dose	dose	NN
cord-005941-e4fvj54l	457	24	regimen	regimen	NN
cord-005941-e4fvj54l	457	25	was	be	VBD
cord-005941-e4fvj54l	457	26	shown	show	VBN
cord-005941-e4fvj54l	457	27	to	to	TO
cord-005941-e4fvj54l	457	28	reduce	reduce	VB
cord-005941-e4fvj54l	457	29	mortality	mortality	NN
cord-005941-e4fvj54l	457	30	and	and	CC
cord-005941-e4fvj54l	457	31	perinatal	perinatal	JJ
cord-005941-e4fvj54l	457	32	morbidity	morbidity	NN
cord-005941-e4fvj54l	457	33	.	.	.
cord-005941-e4fvj54l	458	1	However	however	RB
cord-005941-e4fvj54l	458	2	,	,	,
cord-005941-e4fvj54l	458	3	in	in	IN
cord-005941-e4fvj54l	458	4	a	a	DT
cord-005941-e4fvj54l	458	5	sheep	sheep	NN
cord-005941-e4fvj54l	458	6	model	model	NN
cord-005941-e4fvj54l	458	7	of	of	IN
cord-005941-e4fvj54l	458	8	ARDS	ARDS	NNP
cord-005941-e4fvj54l	458	9	,	,	,
cord-005941-e4fvj54l	458	10	aerosolized	aerosolize	VBN
cord-005941-e4fvj54l	458	11	Exosurf	Exosurf	NNP
cord-005941-e4fvj54l	458	12	failed	fail	VBD
cord-005941-e4fvj54l	458	13	to	to	TO
cord-005941-e4fvj54l	458	14	demonstrate	demonstrate	VB
cord-005941-e4fvj54l	458	15	a	a	DT
cord-005941-e4fvj54l	458	16	beneficial	beneficial	JJ
cord-005941-e4fvj54l	458	17	effect	effect	NN
cord-005941-e4fvj54l	458	18	[	[	-LRB-
cord-005941-e4fvj54l	458	19	200	200	CD
cord-005941-e4fvj54l	458	20	]	]	-RRB-
cord-005941-e4fvj54l	458	21	.	.	.
cord-005941-e4fvj54l	459	1	Presently	presently	RB
cord-005941-e4fvj54l	459	2	,	,	,
cord-005941-e4fvj54l	459	3	great	great	JJ
cord-005941-e4fvj54l	459	4	efforts	effort	NNS
cord-005941-e4fvj54l	459	5	are	be	VBP
cord-005941-e4fvj54l	459	6	being	be	VBG
cord-005941-e4fvj54l	459	7	made	make	VBN
cord-005941-e4fvj54l	459	8	to	to	TO
cord-005941-e4fvj54l	459	9	produce	produce	VB
cord-005941-e4fvj54l	459	10	synthetic	synthetic	JJ
cord-005941-e4fvj54l	459	11	surfactants	surfactant	NNS
cord-005941-e4fvj54l	459	12	which	which	WDT
cord-005941-e4fvj54l	459	13	resemble	resemble	VBP
cord-005941-e4fvj54l	459	14	natural	natural	JJ
cord-005941-e4fvj54l	459	15	surfactants	surfactant	NNS
cord-005941-e4fvj54l	459	16	more	more	RBR
cord-005941-e4fvj54l	459	17	closely	closely	RB
cord-005941-e4fvj54l	459	18	.	.	.
cord-005941-e4fvj54l	460	1	The	the	DT
cord-005941-e4fvj54l	460	2	genes	gene	NNS
cord-005941-e4fvj54l	460	3	of	of	IN
cord-005941-e4fvj54l	460	4	SP	SP	NNP
cord-005941-e4fvj54l	460	5	-	-	HYPH
cord-005941-e4fvj54l	460	6	A	A	NNP
cord-005941-e4fvj54l	460	7	,	,	,
cord-005941-e4fvj54l	460	8	B	b	NN
cord-005941-e4fvj54l	460	9	,	,	,
cord-005941-e4fvj54l	460	10	and	and	CC
cord-005941-e4fvj54l	460	11	C	C	NNP
cord-005941-e4fvj54l	460	12	have	have	VBP
cord-005941-e4fvj54l	460	13	been	be	VBN
cord-005941-e4fvj54l	460	14	cloned	clone	VBN
cord-005941-e4fvj54l	460	15	so	so	IN
cord-005941-e4fvj54l	460	16	that	that	IN
cord-005941-e4fvj54l	460	17	these	these	DT
cord-005941-e4fvj54l	460	18	proteins	protein	NNS
cord-005941-e4fvj54l	460	19	can	can	MD
cord-005941-e4fvj54l	460	20	be	be	VB
cord-005941-e4fvj54l	460	21	produced	produce	VBN
cord-005941-e4fvj54l	460	22	by	by	IN
cord-005941-e4fvj54l	460	23	methods	method	NNS
cord-005941-e4fvj54l	460	24	of	of	IN
cord-005941-e4fvj54l	460	25	recombinant	recombinant	JJ
cord-005941-e4fvj54l	460	26	DNA	dna	NN
cord-005941-e4fvj54l	460	27	technology	technology	NN
cord-005941-e4fvj54l	460	28	[	[	-LRB-
cord-005941-e4fvj54l	460	29	158	158	CD
cord-005941-e4fvj54l	460	30	]	]	-RRB-
cord-005941-e4fvj54l	460	31	.	.	.
cord-005941-e4fvj54l	461	1	Surfactant	surfactant	NN
cord-005941-e4fvj54l	461	2	phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	461	3	can	can	MD
cord-005941-e4fvj54l	461	4	easily	easily	RB
cord-005941-e4fvj54l	461	5	be	be	VB
cord-005941-e4fvj54l	461	6	produced	produce	VBN
cord-005941-e4fvj54l	461	7	by	by	IN
cord-005941-e4fvj54l	461	8	chemical	chemical	NN
cord-005941-e4fvj54l	461	9	synthesis	synthesis	NN
cord-005941-e4fvj54l	461	10	.	.	.
cord-005941-e4fvj54l	462	1	Thus	thus	RB
cord-005941-e4fvj54l	462	2	,	,	,
cord-005941-e4fvj54l	462	3	different	different	JJ
cord-005941-e4fvj54l	462	4	surfactant	surfactant	NN
cord-005941-e4fvj54l	462	5	preparations	preparation	NNS
cord-005941-e4fvj54l	462	6	can	can	MD
cord-005941-e4fvj54l	462	7	now	now	RB
cord-005941-e4fvj54l	462	8	be	be	VB
cord-005941-e4fvj54l	462	9	designed	design	VBN
cord-005941-e4fvj54l	462	10	and	and	CC
cord-005941-e4fvj54l	462	11	studied	study	VBN
cord-005941-e4fvj54l	462	12	in	in	IN
cord-005941-e4fvj54l	462	13	vitro	vitro	FW
cord-005941-e4fvj54l	462	14	and	and	CC
cord-005941-e4fvj54l	462	15	in	in	IN
cord-005941-e4fvj54l	462	16	vivo	vivo	NNP
cord-005941-e4fvj54l	462	17	.	.	.
cord-005941-e4fvj54l	463	1	These	these	DT
cord-005941-e4fvj54l	463	2	syn	syn	NN
cord-005941-e4fvj54l	463	3	-	-	HYPH
cord-005941-e4fvj54l	463	4	thetic	thetic	JJ
cord-005941-e4fvj54l	463	5	surfactants	surfactant	NNS
cord-005941-e4fvj54l	463	6	will	will	MD
cord-005941-e4fvj54l	463	7	have	have	VB
cord-005941-e4fvj54l	463	8	the	the	DT
cord-005941-e4fvj54l	463	9	advantage	advantage	NN
cord-005941-e4fvj54l	463	10	of	of	IN
cord-005941-e4fvj54l	463	11	high	high	JJ
cord-005941-e4fvj54l	463	12	quality	quality	NN
cord-005941-e4fvj54l	463	13	and	and	CC
cord-005941-e4fvj54l	463	14	nearly	nearly	RB
cord-005941-e4fvj54l	463	15	unlimited	unlimited	JJ
cord-005941-e4fvj54l	463	16	availability	availability	NN
cord-005941-e4fvj54l	463	17	,	,	,
cord-005941-e4fvj54l	463	18	which	which	WDT
cord-005941-e4fvj54l	463	19	is	be	VBZ
cord-005941-e4fvj54l	463	20	an	an	DT
cord-005941-e4fvj54l	463	21	important	important	JJ
cord-005941-e4fvj54l	463	22	prerequisite	prerequisite	NN
cord-005941-e4fvj54l	463	23	for	for	IN
cord-005941-e4fvj54l	463	24	pharmacological	pharmacological	JJ
cord-005941-e4fvj54l	463	25	trials	trial	NNS
cord-005941-e4fvj54l	463	26	and	and	CC
cord-005941-e4fvj54l	463	27	subsequent	subsequent	JJ
cord-005941-e4fvj54l	463	28	clinical	clinical	JJ
cord-005941-e4fvj54l	463	29	use	use	NN
cord-005941-e4fvj54l	463	30	on	on	IN
cord-005941-e4fvj54l	463	31	a	a	DT
cord-005941-e4fvj54l	463	32	larger	large	JJR
cord-005941-e4fvj54l	463	33	scale	scale	NN
cord-005941-e4fvj54l	463	34	.	.	.
cord-005941-e4fvj54l	464	1	However	however	RB
cord-005941-e4fvj54l	464	2	,	,	,
cord-005941-e4fvj54l	464	3	several	several	JJ
cord-005941-e4fvj54l	464	4	remaining	remain	VBG
cord-005941-e4fvj54l	464	5	issues	issue	NNS
cord-005941-e4fvj54l	464	6	will	will	MD
cord-005941-e4fvj54l	464	7	have	have	VB
cord-005941-e4fvj54l	464	8	to	to	TO
cord-005941-e4fvj54l	464	9	be	be	VB
cord-005941-e4fvj54l	464	10	solved	solve	VBN
cord-005941-e4fvj54l	464	11	,	,	,
cord-005941-e4fvj54l	464	12	e.g.	e.g.	RB
cord-005941-e4fvj54l	464	13	,	,	,
cord-005941-e4fvj54l	464	14	the	the	DT
cord-005941-e4fvj54l	464	15	optimal	optimal	JJ
cord-005941-e4fvj54l	464	16	composition	composition	NN
cord-005941-e4fvj54l	464	17	of	of	IN
cord-005941-e4fvj54l	464	18	such	such	JJ
cord-005941-e4fvj54l	464	19	"	"	``
cord-005941-e4fvj54l	464	20	designer	designer	NN
cord-005941-e4fvj54l	464	21	surfactants	surfactant	NNS
cord-005941-e4fvj54l	464	22	.	.	.
cord-005941-e4fvj54l	465	1	"	"	``
cord-005941-e4fvj54l	465	2	Probably	probably	RB
cord-005941-e4fvj54l	465	3	,	,	,
cord-005941-e4fvj54l	465	4	only	only	RB
cord-005941-e4fvj54l	465	5	the	the	DT
cord-005941-e4fvj54l	465	6	phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	465	7	DPPC	DPPC	NNP
cord-005941-e4fvj54l	465	8	and	and	CC
cord-005941-e4fvj54l	465	9	PG	PG	NNP
cord-005941-e4fvj54l	465	10	will	will	MD
cord-005941-e4fvj54l	465	11	be	be	VB
cord-005941-e4fvj54l	465	12	necessary	necessary	JJ
cord-005941-e4fvj54l	465	13	in	in	IN
cord-005941-e4fvj54l	465	14	conjunction	conjunction	NN
cord-005941-e4fvj54l	465	15	with	with	IN
cord-005941-e4fvj54l	465	16	surfactant	surfactant	NN
cord-005941-e4fvj54l	465	17	proteins	protein	NNS
cord-005941-e4fvj54l	465	18	to	to	TO
cord-005941-e4fvj54l	465	19	guarantee	guarantee	VB
cord-005941-e4fvj54l	465	20	full	full	JJ
cord-005941-e4fvj54l	465	21	surfactant	surfactant	NN
cord-005941-e4fvj54l	465	22	efficacy	efficacy	NN
cord-005941-e4fvj54l	465	23	[	[	-LRB-
cord-005941-e4fvj54l	465	24	158	158	CD
cord-005941-e4fvj54l	465	25	]	]	-RRB-
cord-005941-e4fvj54l	465	26	.	.	.
cord-005941-e4fvj54l	466	1	Another	another	DT
cord-005941-e4fvj54l	466	2	issue	issue	NN
cord-005941-e4fvj54l	466	3	which	which	WDT
cord-005941-e4fvj54l	466	4	is	be	VBZ
cord-005941-e4fvj54l	466	5	presently	presently	RB
cord-005941-e4fvj54l	466	6	debated	debate	VBN
cord-005941-e4fvj54l	466	7	is	be	VBZ
cord-005941-e4fvj54l	466	8	whether	whether	IN
cord-005941-e4fvj54l	466	9	or	or	CC
cord-005941-e4fvj54l	466	10	not	not	RB
cord-005941-e4fvj54l	466	11	SP	SP	NNP
cord-005941-e4fvj54l	466	12	-	-	HYPH
cord-005941-e4fvj54l	466	13	A	A	NNP
cord-005941-e4fvj54l	466	14	is	be	VBZ
cord-005941-e4fvj54l	466	15	a	a	DT
cord-005941-e4fvj54l	466	16	necessary	necessary	JJ
cord-005941-e4fvj54l	466	17	component	component	NN
cord-005941-e4fvj54l	466	18	of	of	IN
cord-005941-e4fvj54l	466	19	synthetic	synthetic	JJ
cord-005941-e4fvj54l	466	20	surfactant	surfactant	NN
cord-005941-e4fvj54l	466	21	preparations	preparation	NNS
cord-005941-e4fvj54l	466	22	.	.	.
cord-005941-e4fvj54l	467	1	Bovine	bovine	JJ
cord-005941-e4fvj54l	467	2	and	and	CC
cord-005941-e4fvj54l	467	3	porcine	porcine	JJ
cord-005941-e4fvj54l	467	4	surfactant	surfactant	NN
cord-005941-e4fvj54l	467	5	preparations	preparation	NNS
cord-005941-e4fvj54l	467	6	without	without	IN
cord-005941-e4fvj54l	467	7	SP	SP	NNP
cord-005941-e4fvj54l	467	8	-	-	HYPH
cord-005941-e4fvj54l	467	9	A	A	NNP
cord-005941-e4fvj54l	467	10	have	have	VBP
cord-005941-e4fvj54l	467	11	already	already	RB
cord-005941-e4fvj54l	467	12	been	be	VBN
cord-005941-e4fvj54l	467	13	shown	show	VBN
cord-005941-e4fvj54l	467	14	to	to	TO
cord-005941-e4fvj54l	467	15	be	be	VB
cord-005941-e4fvj54l	467	16	effective	effective	JJ
cord-005941-e4fvj54l	467	17	,	,	,
cord-005941-e4fvj54l	467	18	and	and	CC
cord-005941-e4fvj54l	467	19	it	-PRON-	PRP
cord-005941-e4fvj54l	467	20	is	be	VBZ
cord-005941-e4fvj54l	467	21	feared	fear	VBN
cord-005941-e4fvj54l	467	22	that	that	IN
cord-005941-e4fvj54l	467	23	the	the	DT
cord-005941-e4fvj54l	467	24	addition	addition	NN
cord-005941-e4fvj54l	467	25	of	of	IN
cord-005941-e4fvj54l	467	26	SP	SP	NNP
cord-005941-e4fvj54l	467	27	-	-	HYPH
cord-005941-e4fvj54l	467	28	A	A	NNP
cord-005941-e4fvj54l	467	29	may	may	MD
cord-005941-e4fvj54l	467	30	increase	increase	VB
cord-005941-e4fvj54l	467	31	the	the	DT
cord-005941-e4fvj54l	467	32	immunogenicity	immunogenicity	NN
cord-005941-e4fvj54l	467	33	and	and	CC
cord-005941-e4fvj54l	467	34	impair	impair	VB
cord-005941-e4fvj54l	467	35	the	the	DT
cord-005941-e4fvj54l	467	36	stability	stability	NN
cord-005941-e4fvj54l	467	37	of	of	IN
cord-005941-e4fvj54l	467	38	the	the	DT
cord-005941-e4fvj54l	467	39	preparation	preparation	NN
cord-005941-e4fvj54l	467	40	.	.	.
cord-005941-e4fvj54l	468	1	However	however	RB
cord-005941-e4fvj54l	468	2	,	,	,
cord-005941-e4fvj54l	468	3	the	the	DT
cord-005941-e4fvj54l	468	4	addition	addition	NN
cord-005941-e4fvj54l	468	5	of	of	IN
cord-005941-e4fvj54l	468	6	SP	SP	NNP
cord-005941-e4fvj54l	468	7	-	-	HYPH
cord-005941-e4fvj54l	468	8	A	A	NNP
cord-005941-e4fvj54l	468	9	enhances	enhance	VBZ
cord-005941-e4fvj54l	468	10	the	the	DT
cord-005941-e4fvj54l	468	11	biophysical	biophysical	JJ
cord-005941-e4fvj54l	468	12	activity	activity	NN
cord-005941-e4fvj54l	468	13	and	and	CC
cord-005941-e4fvj54l	468	14	increases	increase	VBZ
cord-005941-e4fvj54l	468	15	the	the	DT
cord-005941-e4fvj54l	468	16	resistance	resistance	NN
cord-005941-e4fvj54l	468	17	of	of	IN
cord-005941-e4fvj54l	468	18	surfactants	surfactant	NNS
cord-005941-e4fvj54l	468	19	against	against	IN
cord-005941-e4fvj54l	468	20	inhibitory	inhibitory	JJ
cord-005941-e4fvj54l	468	21	proteins	protein	NNS
cord-005941-e4fvj54l	468	22	in	in	IN
cord-005941-e4fvj54l	468	23	vitro	vitro	FW
cord-005941-e4fvj54l	468	24	,	,	,
cord-005941-e4fvj54l	468	25	which	which	WDT
cord-005941-e4fvj54l	468	26	seems	seem	VBZ
cord-005941-e4fvj54l	468	27	an	an	DT
cord-005941-e4fvj54l	468	28	important	important	JJ
cord-005941-e4fvj54l	468	29	aspect	aspect	NN
cord-005941-e4fvj54l	468	30	,	,	,
cord-005941-e4fvj54l	468	31	especially	especially	RB
cord-005941-e4fvj54l	468	32	when	when	WRB
cord-005941-e4fvj54l	468	33	treating	treat	VBG
cord-005941-e4fvj54l	468	34	ARDS	ARDS	NNP
cord-005941-e4fvj54l	468	35	[	[	-LRB-
cord-005941-e4fvj54l	468	36	179	179	CD
cord-005941-e4fvj54l	468	37	]	]	-RRB-
cord-005941-e4fvj54l	468	38	.	.	.
cord-005941-e4fvj54l	469	1	Most	Most	JJS
cord-005941-e4fvj54l	469	2	data	datum	NNS
cord-005941-e4fvj54l	469	3	on	on	IN
cord-005941-e4fvj54l	469	4	surfactant	surfactant	NN
cord-005941-e4fvj54l	469	5	dosage	dosage	NN
cord-005941-e4fvj54l	469	6	in	in	IN
cord-005941-e4fvj54l	469	7	adults	adult	NNS
cord-005941-e4fvj54l	469	8	are	be	VBP
cord-005941-e4fvj54l	469	9	derived	derive	VBN
cord-005941-e4fvj54l	469	10	from	from	IN
cord-005941-e4fvj54l	469	11	animal	animal	NN
cord-005941-e4fvj54l	469	12	studies	study	NNS
cord-005941-e4fvj54l	469	13	or	or	CC
cord-005941-e4fvj54l	469	14	clinical	clinical	JJ
cord-005941-e4fvj54l	469	15	trials	trial	NNS
cord-005941-e4fvj54l	469	16	of	of	IN
cord-005941-e4fvj54l	469	17	IRDS	IRDS	NNP
cord-005941-e4fvj54l	469	18	treatment	treatment	NN
cord-005941-e4fvj54l	469	19	(	(	-LRB-
cord-005941-e4fvj54l	469	20	e.g.	e.g.	RB
cord-005941-e4fvj54l	469	21	,	,	,
cord-005941-e4fvj54l	469	22	[	[	-LRB-
cord-005941-e4fvj54l	469	23	27	27	CD
cord-005941-e4fvj54l	469	24	,	,	,
cord-005941-e4fvj54l	469	25	47	47	CD
cord-005941-e4fvj54l	469	26	,	,	,
cord-005941-e4fvj54l	469	27	58	58	CD
cord-005941-e4fvj54l	469	28	,	,	,
cord-005941-e4fvj54l	469	29	79	79	CD
cord-005941-e4fvj54l	469	30	,	,	,
cord-005941-e4fvj54l	469	31	166	166	CD
cord-005941-e4fvj54l	469	32	]	]	-RRB-
cord-005941-e4fvj54l	469	33	)	)	-RRB-
cord-005941-e4fvj54l	469	34	.	.	.
cord-005941-e4fvj54l	470	1	Usually	usually	RB
cord-005941-e4fvj54l	470	2	,	,	,
cord-005941-e4fvj54l	470	3	a	a	DT
cord-005941-e4fvj54l	470	4	single	single	JJ
cord-005941-e4fvj54l	470	5	dose	dose	NN
cord-005941-e4fvj54l	470	6	or	or	CC
cord-005941-e4fvj54l	470	7	a	a	DT
cord-005941-e4fvj54l	470	8	two	two	CD
cord-005941-e4fvj54l	470	9	-	-	HYPH
cord-005941-e4fvj54l	470	10	dose	dose	NN
cord-005941-e4fvj54l	470	11	regimen	regimen	NN
cord-005941-e4fvj54l	470	12	is	be	VBZ
cord-005941-e4fvj54l	470	13	preferred	prefer	VBN
cord-005941-e4fvj54l	470	14	over	over	IN
cord-005941-e4fvj54l	470	15	repeated	repeat	VBN
cord-005941-e4fvj54l	470	16	surfactant	surfactant	NN
cord-005941-e4fvj54l	470	17	instillations	instillation	NNS
cord-005941-e4fvj54l	470	18	.	.	.
cord-005941-e4fvj54l	471	1	An	an	DT
cord-005941-e4fvj54l	471	2	adequate	adequate	JJ
cord-005941-e4fvj54l	471	3	single	single	JJ
cord-005941-e4fvj54l	471	4	dose	dose	NN
cord-005941-e4fvj54l	471	5	for	for	IN
cord-005941-e4fvj54l	471	6	the	the	DT
cord-005941-e4fvj54l	471	7	treatment	treatment	NN
cord-005941-e4fvj54l	471	8	of	of	IN
cord-005941-e4fvj54l	471	9	ARDS	ARDS	NNP
cord-005941-e4fvj54l	471	10	is	be	VBZ
cord-005941-e4fvj54l	471	11	thought	think	VBN
cord-005941-e4fvj54l	471	12	to	to	TO
cord-005941-e4fvj54l	471	13	be	be	VB
cord-005941-e4fvj54l	471	14	in	in	IN
cord-005941-e4fvj54l	471	15	the	the	DT
cord-005941-e4fvj54l	471	16	range	range	NN
cord-005941-e4fvj54l	471	17	of	of	IN
cord-005941-e4fvj54l	471	18	50	50	CD
cord-005941-e4fvj54l	471	19	-	-	SYM
cord-005941-e4fvj54l	471	20	300	300	CD
cord-005941-e4fvj54l	471	21	mg	mg	NNP
cord-005941-e4fvj54l	471	22	phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	471	23	/	/	SYM
cord-005941-e4fvj54l	471	24	kg	kg	NN
cord-005941-e4fvj54l	471	25	body	body	NN
cord-005941-e4fvj54l	471	26	weight	weight	NN
cord-005941-e4fvj54l	471	27	[	[	-LRB-
cord-005941-e4fvj54l	471	28	36	36	CD
cord-005941-e4fvj54l	471	29	,	,	,
cord-005941-e4fvj54l	471	30	71	71	CD
cord-005941-e4fvj54l	471	31	,	,	,
cord-005941-e4fvj54l	471	32	83	83	CD
cord-005941-e4fvj54l	471	33	,	,	,
cord-005941-e4fvj54l	471	34	85	85	CD
cord-005941-e4fvj54l	471	35	,	,	,
cord-005941-e4fvj54l	471	36	100	100	CD
cord-005941-e4fvj54l	471	37	]	]	-RRB-
cord-005941-e4fvj54l	471	38	.	.	.
cord-005941-e4fvj54l	472	1	Alternatively	alternatively	RB
cord-005941-e4fvj54l	472	2	,	,	,
cord-005941-e4fvj54l	472	3	for	for	IN
cord-005941-e4fvj54l	472	4	example	example	NN
cord-005941-e4fvj54l	472	5	,	,	,
cord-005941-e4fvj54l	472	6	a	a	DT
cord-005941-e4fvj54l	472	7	cumulative	cumulative	JJ
cord-005941-e4fvj54l	472	8	total	total	JJ
cord-005941-e4fvj54l	472	9	dose	dose	NN
cord-005941-e4fvj54l	472	10	of	of	IN
cord-005941-e4fvj54l	472	11	4	4	CD
cord-005941-e4fvj54l	472	12	g	g	NN
cord-005941-e4fvj54l	472	13	has	have	VBZ
cord-005941-e4fvj54l	472	14	been	be	VBN
cord-005941-e4fvj54l	472	15	used	use	VBN
cord-005941-e4fvj54l	472	16	[	[	-LRB-
cord-005941-e4fvj54l	472	17	152	152	CD
cord-005941-e4fvj54l	472	18	]	]	-RRB-
cord-005941-e4fvj54l	472	19	.	.	.
cord-005941-e4fvj54l	473	1	Surfactant	surfactant	NN
cord-005941-e4fvj54l	473	2	preparations	preparation	NNS
cord-005941-e4fvj54l	473	3	containing	contain	VBG
cord-005941-e4fvj54l	473	4	proteins	protein	NNS
cord-005941-e4fvj54l	473	5	should	should	MD
cord-005941-e4fvj54l	473	6	be	be	VB
cord-005941-e4fvj54l	473	7	expected	expect	VBN
cord-005941-e4fvj54l	473	8	to	to	TO
cord-005941-e4fvj54l	473	9	have	have	VB
cord-005941-e4fvj54l	473	10	a	a	DT
cord-005941-e4fvj54l	473	11	potential	potential	NN
cord-005941-e4fvj54l	473	12	for	for	IN
cord-005941-e4fvj54l	473	13	sensitization	sensitization	NN
cord-005941-e4fvj54l	473	14	of	of	IN
cord-005941-e4fvj54l	473	15	a	a	DT
cord-005941-e4fvj54l	473	16	patient	patient	NN
cord-005941-e4fvj54l	473	17	to	to	IN
cord-005941-e4fvj54l	473	18	foreign	foreign	JJ
cord-005941-e4fvj54l	473	19	proteins	protein	NNS
cord-005941-e4fvj54l	473	20	.	.	.
cord-005941-e4fvj54l	474	1	Data	datum	NNS
cord-005941-e4fvj54l	474	2	from	from	IN
cord-005941-e4fvj54l	474	3	children	child	NNS
cord-005941-e4fvj54l	474	4	with	with	IN
cord-005941-e4fvj54l	474	5	IRDS	IRDS	NNP
cord-005941-e4fvj54l	474	6	treated	treat	VBN
cord-005941-e4fvj54l	474	7	with	with	IN
cord-005941-e4fvj54l	474	8	exogenous	exogenous	JJ
cord-005941-e4fvj54l	474	9	surfactant	surfactant	NN
cord-005941-e4fvj54l	474	10	indicate	indicate	VBP
cord-005941-e4fvj54l	474	11	that	that	IN
cord-005941-e4fvj54l	474	12	circulating	circulate	VBG
cord-005941-e4fvj54l	474	13	surfactant	surfactant	NN
cord-005941-e4fvj54l	474	14	-	-	HYPH
cord-005941-e4fvj54l	474	15	anti	anti	NN
cord-005941-e4fvj54l	474	16	-	-	JJ
cord-005941-e4fvj54l	474	17	surfactant	surfactant	JJ
cord-005941-e4fvj54l	474	18	immune	immune	JJ
cord-005941-e4fvj54l	474	19	complexes	complex	NNS
cord-005941-e4fvj54l	474	20	frequently	frequently	RB
cord-005941-e4fvj54l	474	21	occur	occur	VBP
cord-005941-e4fvj54l	474	22	[	[	-LRB-
cord-005941-e4fvj54l	474	23	117	117	CD
cord-005941-e4fvj54l	474	24	]	]	-RRB-
cord-005941-e4fvj54l	474	25	.	.	.
cord-005941-e4fvj54l	475	1	However	however	RB
cord-005941-e4fvj54l	475	2	,	,	,
cord-005941-e4fvj54l	475	3	many	many	JJ
cord-005941-e4fvj54l	475	4	IRDS	irds	NN
cord-005941-e4fvj54l	475	5	patients	patient	NNS
cord-005941-e4fvj54l	475	6	without	without	IN
cord-005941-e4fvj54l	475	7	substitution	substitution	NN
cord-005941-e4fvj54l	475	8	therapy	therapy	NN
cord-005941-e4fvj54l	475	9	also	also	RB
cord-005941-e4fvj54l	475	10	seem	seem	VBP
cord-005941-e4fvj54l	475	11	to	to	TO
cord-005941-e4fvj54l	475	12	have	have	VB
cord-005941-e4fvj54l	475	13	such	such	JJ
cord-005941-e4fvj54l	475	14	circulating	circulate	VBG
cord-005941-e4fvj54l	475	15	immune	immune	JJ
cord-005941-e4fvj54l	475	16	complexes	complex	NNS
cord-005941-e4fvj54l	475	17	[	[	-LRB-
cord-005941-e4fvj54l	475	18	167	167	CD
cord-005941-e4fvj54l	475	19	]	]	-RRB-
cord-005941-e4fvj54l	475	20	,	,	,
cord-005941-e4fvj54l	475	21	and	and	CC
cord-005941-e4fvj54l	475	22	negative	negative	JJ
cord-005941-e4fvj54l	475	23	effects	effect	NNS
cord-005941-e4fvj54l	475	24	have	have	VBP
cord-005941-e4fvj54l	475	25	not	not	RB
cord-005941-e4fvj54l	475	26	yet	yet	RB
cord-005941-e4fvj54l	475	27	been	be	VBN
cord-005941-e4fvj54l	475	28	observed	observe	VBN
cord-005941-e4fvj54l	475	29	.	.	.
cord-005941-e4fvj54l	476	1	A	a	DT
cord-005941-e4fvj54l	476	2	recently	recently	RB
cord-005941-e4fvj54l	476	3	published	publish	VBN
cord-005941-e4fvj54l	476	4	study	study	NN
cord-005941-e4fvj54l	476	5	[	[	-LRB-
cord-005941-e4fvj54l	476	6	19	19	CD
cord-005941-e4fvj54l	476	7	]	]	-RRB-
cord-005941-e4fvj54l	476	8	demonstrated	demonstrate	VBD
cord-005941-e4fvj54l	476	9	IgM	IgM	NNP
cord-005941-e4fvj54l	476	10	antibodies	antibody	NNS
cord-005941-e4fvj54l	476	11	to	to	TO
cord-005941-e4fvj54l	476	12	surfactant	surfactant	VB
cord-005941-e4fvj54l	476	13	specific	specific	JJ
cord-005941-e4fvj54l	476	14	proteins	protein	NNS
cord-005941-e4fvj54l	476	15	in	in	IN
cord-005941-e4fvj54l	476	16	patients	patient	NNS
cord-005941-e4fvj54l	476	17	with	with	IN
cord-005941-e4fvj54l	476	18	severe	severe	JJ
cord-005941-e4fvj54l	476	19	IRDS	irds	NN
cord-005941-e4fvj54l	476	20	and	and	CC
cord-005941-e4fvj54l	476	21	showed	show	VBD
cord-005941-e4fvj54l	476	22	that	that	IN
cord-005941-e4fvj54l	476	23	the	the	DT
cord-005941-e4fvj54l	476	24	antibody	antibody	NN
cord-005941-e4fvj54l	476	25	occurrence	occurrence	NN
cord-005941-e4fvj54l	476	26	decreased	decrease	VBD
cord-005941-e4fvj54l	476	27	after	after	IN
cord-005941-e4fvj54l	476	28	surfactant	surfactant	NN
cord-005941-e4fvj54l	476	29	treatment	treatment	NN
cord-005941-e4fvj54l	476	30	.	.	.
cord-005941-e4fvj54l	477	1	It	-PRON-	PRP
cord-005941-e4fvj54l	477	2	was	be	VBD
cord-005941-e4fvj54l	477	3	concluded	conclude	VBN
cord-005941-e4fvj54l	477	4	that	that	IN
cord-005941-e4fvj54l	477	5	IRDS	IRDS	NNP
cord-005941-e4fvj54l	477	6	can	can	MD
cord-005941-e4fvj54l	477	7	lead	lead	VB
cord-005941-e4fvj54l	477	8	to	to	IN
cord-005941-e4fvj54l	477	9	a	a	DT
cord-005941-e4fvj54l	477	10	leak	leak	NN
cord-005941-e4fvj54l	477	11	of	of	IN
cord-005941-e4fvj54l	477	12	surfactant	surfactant	NN
cord-005941-e4fvj54l	477	13	-	-	HYPH
cord-005941-e4fvj54l	477	14	specific	specific	JJ
cord-005941-e4fvj54l	477	15	proteins	protein	NNS
cord-005941-e4fvj54l	477	16	into	into	IN
cord-005941-e4fvj54l	477	17	the	the	DT
cord-005941-e4fvj54l	477	18	circulation	circulation	NN
cord-005941-e4fvj54l	477	19	and	and	CC
cord-005941-e4fvj54l	477	20	that	that	IN
cord-005941-e4fvj54l	477	21	surfactant	surfactant	NN
cord-005941-e4fvj54l	477	22	treat-652	treat-652	NN
cord-005941-e4fvj54l	477	23	ment	ment	NN
cord-005941-e4fvj54l	477	24	may	may	MD
cord-005941-e4fvj54l	477	25	reduce	reduce	VB
cord-005941-e4fvj54l	477	26	this	this	DT
cord-005941-e4fvj54l	477	27	leak	leak	NN
cord-005941-e4fvj54l	477	28	by	by	IN
cord-005941-e4fvj54l	477	29	reducing	reduce	VBG
cord-005941-e4fvj54l	477	30	the	the	DT
cord-005941-e4fvj54l	477	31	lung	lung	NN
cord-005941-e4fvj54l	477	32	damage	damage	NN
cord-005941-e4fvj54l	477	33	.	.	.
cord-005941-e4fvj54l	478	1	Another	another	DT
cord-005941-e4fvj54l	478	2	issue	issue	NN
cord-005941-e4fvj54l	478	3	is	be	VBZ
cord-005941-e4fvj54l	478	4	that	that	IN
cord-005941-e4fvj54l	478	5	exogenous	exogenous	JJ
cord-005941-e4fvj54l	478	6	surfactant	surfactant	NN
cord-005941-e4fvj54l	478	7	could	could	MD
cord-005941-e4fvj54l	478	8	interfere	interfere	VB
cord-005941-e4fvj54l	478	9	with	with	IN
cord-005941-e4fvj54l	478	10	endogenous	endogenous	JJ
cord-005941-e4fvj54l	478	11	surfactant	surfactant	NN
cord-005941-e4fvj54l	478	12	synthesis	synthesis	NN
cord-005941-e4fvj54l	478	13	and	and	CC
cord-005941-e4fvj54l	478	14	secretion	secretion	NN
cord-005941-e4fvj54l	478	15	.	.	.
cord-005941-e4fvj54l	479	1	Indeed	indeed	RB
cord-005941-e4fvj54l	479	2	,	,	,
cord-005941-e4fvj54l	479	3	in	in	IN
cord-005941-e4fvj54l	479	4	vitro	vitro	FW
cord-005941-e4fvj54l	479	5	evidence	evidence	NN
cord-005941-e4fvj54l	479	6	on	on	IN
cord-005941-e4fvj54l	479	7	surfactant	surfactant	NN
cord-005941-e4fvj54l	479	8	regulation	regulation	NN
cord-005941-e4fvj54l	479	9	(	(	-LRB-
cord-005941-e4fvj54l	479	10	see	see	VB
cord-005941-e4fvj54l	479	11	above	above	RB
cord-005941-e4fvj54l	479	12	)	)	-RRB-
cord-005941-e4fvj54l	479	13	would	would	MD
cord-005941-e4fvj54l	479	14	suggest	suggest	VB
cord-005941-e4fvj54l	479	15	that	that	IN
cord-005941-e4fvj54l	479	16	surfactant	surfactant	NN
cord-005941-e4fvj54l	479	17	substitution	substitution	NN
cord-005941-e4fvj54l	479	18	could	could	MD
cord-005941-e4fvj54l	479	19	have	have	VB
cord-005941-e4fvj54l	479	20	such	such	JJ
cord-005941-e4fvj54l	479	21	unwanted	unwanted	JJ
cord-005941-e4fvj54l	479	22	effects	effect	NNS
cord-005941-e4fvj54l	479	23	,	,	,
cord-005941-e4fvj54l	479	24	e.g.	e.g.	RB
cord-005941-e4fvj54l	479	25	,	,	,
cord-005941-e4fvj54l	479	26	by	by	IN
cord-005941-e4fvj54l	479	27	feedback	feedback	NN
cord-005941-e4fvj54l	479	28	inhibition	inhibition	NN
cord-005941-e4fvj54l	479	29	of	of	IN
cord-005941-e4fvj54l	479	30	type	type	NN
cord-005941-e4fvj54l	479	31	II	ii	CD
cord-005941-e4fvj54l	479	32	cells	cell	NNS
cord-005941-e4fvj54l	479	33	.	.	.
cord-005941-e4fvj54l	480	1	However	however	RB
cord-005941-e4fvj54l	480	2	,	,	,
cord-005941-e4fvj54l	480	3	a	a	DT
cord-005941-e4fvj54l	480	4	recent	recent	JJ
cord-005941-e4fvj54l	480	5	in	in	IN
cord-005941-e4fvj54l	480	6	vivo	vivo	NN
cord-005941-e4fvj54l	480	7	study	study	NN
cord-005941-e4fvj54l	480	8	in	in	IN
cord-005941-e4fvj54l	480	9	rabbits	rabbit	NNS
cord-005941-e4fvj54l	480	10	[	[	-LRB-
cord-005941-e4fvj54l	480	11	129	129	CD
cord-005941-e4fvj54l	480	12	]	]	-RRB-
cord-005941-e4fvj54l	480	13	has	have	VBZ
cord-005941-e4fvj54l	480	14	shown	show	VBN
cord-005941-e4fvj54l	480	15	that	that	IN
cord-005941-e4fvj54l	480	16	this	this	DT
cord-005941-e4fvj54l	480	17	was	be	VBD
cord-005941-e4fvj54l	480	18	not	not	RB
cord-005941-e4fvj54l	480	19	the	the	DT
cord-005941-e4fvj54l	480	20	case	case	NN
cord-005941-e4fvj54l	480	21	.	.	.
cord-005941-e4fvj54l	481	1	On	on	IN
cord-005941-e4fvj54l	481	2	the	the	DT
cord-005941-e4fvj54l	481	3	contrary	contrary	NN
cord-005941-e4fvj54l	481	4	,	,	,
cord-005941-e4fvj54l	481	5	administration	administration	NN
cord-005941-e4fvj54l	481	6	of	of	IN
cord-005941-e4fvj54l	481	7	different	different	JJ
cord-005941-e4fvj54l	481	8	surfactant	surfactant	NN
cord-005941-e4fvj54l	481	9	preparations	preparation	NNS
cord-005941-e4fvj54l	481	10	tended	tend	VBD
cord-005941-e4fvj54l	481	11	to	to	TO
cord-005941-e4fvj54l	481	12	stimulate	stimulate	VB
cord-005941-e4fvj54l	481	13	endogenous	endogenous	JJ
cord-005941-e4fvj54l	481	14	surfactant	surfactant	NN
cord-005941-e4fvj54l	481	15	synthesis	synthesis	NN
cord-005941-e4fvj54l	481	16	and	and	CC
cord-005941-e4fvj54l	481	17	secretion	secretion	NN
cord-005941-e4fvj54l	481	18	.	.	.
cord-005941-e4fvj54l	482	1	In	in	IN
cord-005941-e4fvj54l	482	2	conclusion	conclusion	NN
cord-005941-e4fvj54l	482	3	,	,	,
cord-005941-e4fvj54l	482	4	several	several	JJ
cord-005941-e4fvj54l	482	5	studies	study	NNS
cord-005941-e4fvj54l	482	6	and	and	CC
cord-005941-e4fvj54l	482	7	existing	exist	VBG
cord-005941-e4fvj54l	482	8	clinical	clinical	JJ
cord-005941-e4fvj54l	482	9	experience	experience	NN
cord-005941-e4fvj54l	482	10	suggest	suggest	VBP
cord-005941-e4fvj54l	482	11	that	that	IN
cord-005941-e4fvj54l	482	12	surfactant	surfactant	NN
cord-005941-e4fvj54l	482	13	substitution	substitution	NN
cord-005941-e4fvj54l	482	14	therapy	therapy	NN
cord-005941-e4fvj54l	482	15	is	be	VBZ
cord-005941-e4fvj54l	482	16	not	not	RB
cord-005941-e4fvj54l	482	17	associated	associate	VBN
cord-005941-e4fvj54l	482	18	with	with	IN
cord-005941-e4fvj54l	482	19	serious	serious	JJ
cord-005941-e4fvj54l	482	20	risks	risk	NNS
cord-005941-e4fvj54l	482	21	.	.	.
cord-005941-e4fvj54l	483	1	However	however	RB
cord-005941-e4fvj54l	483	2	,	,	,
cord-005941-e4fvj54l	483	3	possible	possible	JJ
cord-005941-e4fvj54l	483	4	long	long	JJ
cord-005941-e4fvj54l	483	5	-	-	HYPH
cord-005941-e4fvj54l	483	6	term	term	NN
cord-005941-e4fvj54l	483	7	effects	effect	NNS
cord-005941-e4fvj54l	483	8	are	be	VBP
cord-005941-e4fvj54l	483	9	not	not	RB
cord-005941-e4fvj54l	483	10	yet	yet	RB
cord-005941-e4fvj54l	483	11	known	know	VBN
cord-005941-e4fvj54l	483	12	,	,	,
cord-005941-e4fvj54l	483	13	and	and	CC
cord-005941-e4fvj54l	483	14	further	further	JJ
cord-005941-e4fvj54l	483	15	studies	study	NNS
cord-005941-e4fvj54l	483	16	should	should	MD
cord-005941-e4fvj54l	483	17	continue	continue	VB
cord-005941-e4fvj54l	483	18	to	to	TO
cord-005941-e4fvj54l	483	19	monitor	monitor	VB
cord-005941-e4fvj54l	483	20	patients	patient	NNS
cord-005941-e4fvj54l	483	21	for	for	IN
cord-005941-e4fvj54l	483	22	potential	potential	JJ
cord-005941-e4fvj54l	483	23	side	side	NN
cord-005941-e4fvj54l	483	24	effects	effect	NNS
cord-005941-e4fvj54l	483	25	of	of	IN
cord-005941-e4fvj54l	483	26	surfactant	surfactant	NN
cord-005941-e4fvj54l	483	27	treatment	treatment	NN
cord-005941-e4fvj54l	483	28	.	.	.
cord-005941-e4fvj54l	484	1	Pharmacologic	Pharmacologic	NNP
cord-005941-e4fvj54l	484	2	improvement	improvement	NN
cord-005941-e4fvj54l	484	3	of	of	IN
cord-005941-e4fvj54l	484	4	surfactant	surfactant	NN
cord-005941-e4fvj54l	484	5	abnormalities	abnormality	NNS
cord-005941-e4fvj54l	484	6	or	or	CC
cord-005941-e4fvj54l	484	7	deficits	deficit	NNS
cord-005941-e4fvj54l	484	8	in	in	IN
cord-005941-e4fvj54l	484	9	human	human	JJ
cord-005941-e4fvj54l	484	10	lung	lung	NN
cord-005941-e4fvj54l	484	11	diseases	disease	NNS
cord-005941-e4fvj54l	484	12	,	,	,
cord-005941-e4fvj54l	484	13	especially	especially	RB
cord-005941-e4fvj54l	484	14	in	in	IN
cord-005941-e4fvj54l	484	15	ARDS	ARDS	NNP
cord-005941-e4fvj54l	484	16	,	,	,
cord-005941-e4fvj54l	484	17	would	would	MD
cord-005941-e4fvj54l	484	18	be	be	VB
cord-005941-e4fvj54l	484	19	of	of	IN
cord-005941-e4fvj54l	484	20	considerable	considerable	JJ
cord-005941-e4fvj54l	484	21	clinical	clinical	JJ
cord-005941-e4fvj54l	484	22	value	value	NN
cord-005941-e4fvj54l	484	23	.	.	.
cord-005941-e4fvj54l	485	1	Despite	despite	IN
cord-005941-e4fvj54l	485	2	some	some	DT
cord-005941-e4fvj54l	485	3	encouraging	encourage	VBG
cord-005941-e4fvj54l	485	4	in	in	IN
cord-005941-e4fvj54l	485	5	vitro	vitro	FW
cord-005941-e4fvj54l	485	6	and	and	CC
cord-005941-e4fvj54l	485	7	animal	animal	NN
cord-005941-e4fvj54l	485	8	studies	study	NNS
cord-005941-e4fvj54l	485	9	,	,	,
cord-005941-e4fvj54l	485	10	no	no	DT
cord-005941-e4fvj54l	485	11	clinical	clinical	JJ
cord-005941-e4fvj54l	485	12	studies	study	NNS
cord-005941-e4fvj54l	485	13	have	have	VBP
cord-005941-e4fvj54l	485	14	yet	yet	RB
cord-005941-e4fvj54l	485	15	convincingly	convincingly	RB
cord-005941-e4fvj54l	485	16	demonstrated	demonstrate	VBN
cord-005941-e4fvj54l	485	17	the	the	DT
cord-005941-e4fvj54l	485	18	usefulness	usefulness	NN
cord-005941-e4fvj54l	485	19	of	of	IN
cord-005941-e4fvj54l	485	20	theoretically	theoretically	RB
cord-005941-e4fvj54l	485	21	promising	promise	VBG
cord-005941-e4fvj54l	485	22	pharmacologic	pharmacologic	JJ
cord-005941-e4fvj54l	485	23	agents	agent	NNS
cord-005941-e4fvj54l	485	24	.	.	.
cord-005941-e4fvj54l	486	1	One	one	CD
cord-005941-e4fvj54l	486	2	of	of	IN
cord-005941-e4fvj54l	486	3	the	the	DT
cord-005941-e4fvj54l	486	4	problems	problem	NNS
cord-005941-e4fvj54l	486	5	in	in	IN
cord-005941-e4fvj54l	486	6	ARDS	ARDS	NNP
cord-005941-e4fvj54l	486	7	is	be	VBZ
cord-005941-e4fvj54l	486	8	probably	probably	RB
cord-005941-e4fvj54l	486	9	that	that	DT
cord-005941-e4fvj54l	486	10	successful	successful	JJ
cord-005941-e4fvj54l	486	11	pharmacological	pharmacological	JJ
cord-005941-e4fvj54l	486	12	substances	substance	NNS
cord-005941-e4fvj54l	486	13	would	would	MD
cord-005941-e4fvj54l	486	14	require	require	VB
cord-005941-e4fvj54l	486	15	very	very	RB
cord-005941-e4fvj54l	486	16	strong	strong	JJ
cord-005941-e4fvj54l	486	17	stimulatory	stimulatory	JJ
cord-005941-e4fvj54l	486	18	effects	effect	NNS
cord-005941-e4fvj54l	486	19	on	on	IN
cord-005941-e4fvj54l	486	20	alveolar	alveolar	NN
cord-005941-e4fvj54l	486	21	type	type	NN
cord-005941-e4fvj54l	486	22	II	ii	CD
cord-005941-e4fvj54l	486	23	cells	cell	NNS
cord-005941-e4fvj54l	486	24	to	to	TO
cord-005941-e4fvj54l	486	25	overcome	overcome	VB
cord-005941-e4fvj54l	486	26	not	not	RB
cord-005941-e4fvj54l	486	27	only	only	RB
cord-005941-e4fvj54l	486	28	the	the	DT
cord-005941-e4fvj54l	486	29	alveolar	alveolar	NN
cord-005941-e4fvj54l	486	30	surfactant	surfactant	NN
cord-005941-e4fvj54l	486	31	deficit	deficit	NN
cord-005941-e4fvj54l	486	32	but	but	CC
cord-005941-e4fvj54l	486	33	also	also	RB
cord-005941-e4fvj54l	486	34	the	the	DT
cord-005941-e4fvj54l	486	35	inhibitory	inhibitory	JJ
cord-005941-e4fvj54l	486	36	effects	effect	NNS
cord-005941-e4fvj54l	486	37	of	of	IN
cord-005941-e4fvj54l	486	38	exudated	exudated	JJ
cord-005941-e4fvj54l	486	39	proteins	protein	NNS
cord-005941-e4fvj54l	486	40	in	in	IN
cord-005941-e4fvj54l	486	41	the	the	DT
cord-005941-e4fvj54l	486	42	alveoli	alveolus	NNS
cord-005941-e4fvj54l	486	43	.	.	.
cord-005941-e4fvj54l	487	1	Steroids	steroid	NNS
cord-005941-e4fvj54l	487	2	are	be	VBP
cord-005941-e4fvj54l	487	3	known	know	VBN
cord-005941-e4fvj54l	487	4	to	to	TO
cord-005941-e4fvj54l	487	5	interfere	interfere	VB
cord-005941-e4fvj54l	487	6	with	with	IN
cord-005941-e4fvj54l	487	7	many	many	JJ
cord-005941-e4fvj54l	487	8	of	of	IN
cord-005941-e4fvj54l	487	9	the	the	DT
cord-005941-e4fvj54l	487	10	mechanisms	mechanism	NNS
cord-005941-e4fvj54l	487	11	thought	think	VBN
cord-005941-e4fvj54l	487	12	to	to	TO
cord-005941-e4fvj54l	487	13	be	be	VB
cord-005941-e4fvj54l	487	14	involved	involve	VBN
cord-005941-e4fvj54l	487	15	in	in	IN
cord-005941-e4fvj54l	487	16	ARDS	ARDS	NNP
cord-005941-e4fvj54l	487	17	.	.	.
cord-005941-e4fvj54l	488	1	Their	-PRON-	PRP$
cord-005941-e4fvj54l	488	2	actions	action	NNS
cord-005941-e4fvj54l	488	3	include	include	VBP
cord-005941-e4fvj54l	488	4	beneficial	beneficial	JJ
cord-005941-e4fvj54l	488	5	effects	effect	NNS
cord-005941-e4fvj54l	488	6	on	on	IN
cord-005941-e4fvj54l	488	7	surfactant	surfactant	NN
cord-005941-e4fvj54l	488	8	synthesis	synthesis	NN
cord-005941-e4fvj54l	488	9	.	.	.
cord-005941-e4fvj54l	489	1	However	however	RB
cord-005941-e4fvj54l	489	2	,	,	,
cord-005941-e4fvj54l	489	3	a	a	DT
cord-005941-e4fvj54l	489	4	number	number	NN
cord-005941-e4fvj54l	489	5	of	of	IN
cord-005941-e4fvj54l	489	6	large	large	JJ
cord-005941-e4fvj54l	489	7	clinical	clinical	JJ
cord-005941-e4fvj54l	489	8	trials	trial	NNS
cord-005941-e4fvj54l	489	9	have	have	VBP
cord-005941-e4fvj54l	489	10	not	not	RB
cord-005941-e4fvj54l	489	11	been	be	VBN
cord-005941-e4fvj54l	489	12	able	able	JJ
cord-005941-e4fvj54l	489	13	to	to	TO
cord-005941-e4fvj54l	489	14	prove	prove	VB
cord-005941-e4fvj54l	489	15	a	a	DT
cord-005941-e4fvj54l	489	16	clinical	clinical	JJ
cord-005941-e4fvj54l	489	17	benefit	benefit	NN
cord-005941-e4fvj54l	489	18	of	of	IN
cord-005941-e4fvj54l	489	19	steroid	steroid	NN
cord-005941-e4fvj54l	489	20	therapy	therapy	NN
cord-005941-e4fvj54l	489	21	in	in	IN
cord-005941-e4fvj54l	489	22	ARDS	ARDS	NNP
cord-005941-e4fvj54l	489	23	(	(	-LRB-
cord-005941-e4fvj54l	489	24	for	for	IN
cord-005941-e4fvj54l	489	25	review	review	NN
cord-005941-e4fvj54l	489	26	see	see	VB
cord-005941-e4fvj54l	489	27	[	[	-LRB-
cord-005941-e4fvj54l	489	28	50	50	CD
cord-005941-e4fvj54l	489	29	]	]	-RRB-
cord-005941-e4fvj54l	489	30	)	)	-RRB-
cord-005941-e4fvj54l	489	31	.	.	.
cord-005941-e4fvj54l	490	1	This	this	DT
cord-005941-e4fvj54l	490	2	is	be	VBZ
cord-005941-e4fvj54l	490	3	not	not	RB
cord-005941-e4fvj54l	490	4	necessarily	necessarily	RB
cord-005941-e4fvj54l	490	5	due	due	JJ
cord-005941-e4fvj54l	490	6	to	to	IN
cord-005941-e4fvj54l	490	7	a	a	DT
cord-005941-e4fvj54l	490	8	failure	failure	NN
cord-005941-e4fvj54l	490	9	of	of	IN
cord-005941-e4fvj54l	490	10	steroids	steroid	NNS
cord-005941-e4fvj54l	490	11	to	to	TO
cord-005941-e4fvj54l	490	12	enhance	enhance	VB
cord-005941-e4fvj54l	490	13	surfactant	surfactant	NN
cord-005941-e4fvj54l	490	14	synthesis	synthesis	NN
cord-005941-e4fvj54l	490	15	but	but	CC
cord-005941-e4fvj54l	490	16	may	may	MD
cord-005941-e4fvj54l	490	17	simply	simply	RB
cord-005941-e4fvj54l	490	18	reflect	reflect	VB
cord-005941-e4fvj54l	490	19	the	the	DT
cord-005941-e4fvj54l	490	20	multiple	multiple	JJ
cord-005941-e4fvj54l	490	21	disturbances	disturbance	NNS
cord-005941-e4fvj54l	490	22	associated	associate	VBN
cord-005941-e4fvj54l	490	23	with	with	IN
cord-005941-e4fvj54l	490	24	ARDS	ARDS	NNP
cord-005941-e4fvj54l	490	25	.	.	.
cord-005941-e4fvj54l	491	1	Steroids	steroid	NNS
cord-005941-e4fvj54l	491	2	are	be	VBP
cord-005941-e4fvj54l	491	3	frequently	frequently	RB
cord-005941-e4fvj54l	491	4	and	and	CC
cord-005941-e4fvj54l	491	5	with	with	IN
cord-005941-e4fvj54l	491	6	some	some	DT
cord-005941-e4fvj54l	491	7	success	success	NN
cord-005941-e4fvj54l	491	8	used	use	VBN
cord-005941-e4fvj54l	491	9	in	in	IN
cord-005941-e4fvj54l	491	10	mothers	mother	NNS
cord-005941-e4fvj54l	491	11	at	at	IN
cord-005941-e4fvj54l	491	12	risk	risk	NN
cord-005941-e4fvj54l	491	13	of	of	IN
cord-005941-e4fvj54l	491	14	premature	premature	JJ
cord-005941-e4fvj54l	491	15	delivery	delivery	NN
cord-005941-e4fvj54l	491	16	to	to	TO
cord-005941-e4fvj54l	491	17	prevent	prevent	VB
cord-005941-e4fvj54l	491	18	IRDS	IRDS	NNP
cord-005941-e4fvj54l	491	19	(	(	-LRB-
cord-005941-e4fvj54l	491	20	for	for	IN
cord-005941-e4fvj54l	491	21	review	review	NN
cord-005941-e4fvj54l	491	22	see	see	VB
cord-005941-e4fvj54l	491	23	[	[	-LRB-
cord-005941-e4fvj54l	491	24	124	124	CD
cord-005941-e4fvj54l	491	25	]	]	-RRB-
cord-005941-e4fvj54l	491	26	)	)	-RRB-
cord-005941-e4fvj54l	491	27	.	.	.
cord-005941-e4fvj54l	492	1	Beta	beta	NN
cord-005941-e4fvj54l	492	2	-	-	HYPH
cord-005941-e4fvj54l	492	3	agonists	agonist	NNS
cord-005941-e4fvj54l	492	4	are	be	VBP
cord-005941-e4fvj54l	492	5	able	able	JJ
cord-005941-e4fvj54l	492	6	to	to	TO
cord-005941-e4fvj54l	492	7	enhance	enhance	VB
cord-005941-e4fvj54l	492	8	surfactant	surfactant	NN
cord-005941-e4fvj54l	492	9	synthesis	synthesis	NN
cord-005941-e4fvj54l	492	10	and	and	CC
cord-005941-e4fvj54l	492	11	secretion	secretion	NN
cord-005941-e4fvj54l	492	12	from	from	IN
cord-005941-e4fvj54l	492	13	alveolar	alveolar	JJ
cord-005941-e4fvj54l	492	14	type	type	NN
cord-005941-e4fvj54l	492	15	II	ii	CD
cord-005941-e4fvj54l	492	16	cells	cell	NNS
cord-005941-e4fvj54l	492	17	in	in	IN
cord-005941-e4fvj54l	492	18	vitro	vitro	FW
cord-005941-e4fvj54l	492	19	.	.	.
cord-005941-e4fvj54l	493	1	These	these	DT
cord-005941-e4fvj54l	493	2	agents	agent	NNS
cord-005941-e4fvj54l	493	3	are	be	VBP
cord-005941-e4fvj54l	493	4	also	also	RB
cord-005941-e4fvj54l	493	5	used	use	VBN
cord-005941-e4fvj54l	493	6	to	to	TO
cord-005941-e4fvj54l	493	7	suppress	suppress	VB
cord-005941-e4fvj54l	493	8	premature	premature	JJ
cord-005941-e4fvj54l	493	9	labor	labor	NN
cord-005941-e4fvj54l	493	10	in	in	IN
cord-005941-e4fvj54l	493	11	mothers	mother	NNS
cord-005941-e4fvj54l	493	12	and	and	CC
cord-005941-e4fvj54l	493	13	possibly	possibly	RB
cord-005941-e4fvj54l	493	14	accelerate	accelerate	VB
cord-005941-e4fvj54l	493	15	fetal	fetal	JJ
cord-005941-e4fvj54l	493	16	lung	lung	NN
cord-005941-e4fvj54l	493	17	maturation	maturation	NN
cord-005941-e4fvj54l	493	18	as	as	IN
cord-005941-e4fvj54l	493	19	a	a	DT
cord-005941-e4fvj54l	493	20	beneficial	beneficial	JJ
cord-005941-e4fvj54l	493	21	side	side	NN
cord-005941-e4fvj54l	493	22	effect	effect	NN
cord-005941-e4fvj54l	493	23	[	[	-LRB-
cord-005941-e4fvj54l	493	24	124	124	CD
cord-005941-e4fvj54l	493	25	,	,	,
cord-005941-e4fvj54l	493	26	125	125	CD
cord-005941-e4fvj54l	493	27	]	]	-RRB-
cord-005941-e4fvj54l	493	28	.	.	.
cord-005941-e4fvj54l	494	1	However	however	RB
cord-005941-e4fvj54l	494	2	,	,	,
cord-005941-e4fvj54l	494	3	no	no	DT
cord-005941-e4fvj54l	494	4	clear	clear	JJ
cord-005941-e4fvj54l	494	5	evidence	evidence	NN
cord-005941-e4fvj54l	494	6	has	have	VBZ
cord-005941-e4fvj54l	494	7	so	so	RB
cord-005941-e4fvj54l	494	8	far	far	RB
cord-005941-e4fvj54l	494	9	been	be	VBN
cord-005941-e4fvj54l	494	10	presented	present	VBN
cord-005941-e4fvj54l	494	11	to	to	TO
cord-005941-e4fvj54l	494	12	support	support	VB
cord-005941-e4fvj54l	494	13	such	such	JJ
cord-005941-e4fvj54l	494	14	in	in	IN
cord-005941-e4fvj54l	494	15	vivo	vivo	NN
cord-005941-e4fvj54l	494	16	effects	effect	NNS
cord-005941-e4fvj54l	494	17	of	of	IN
cord-005941-e4fvj54l	494	18	beta	beta	NN
cord-005941-e4fvj54l	494	19	-	-	HYPH
cord-005941-e4fvj54l	494	20	agonists	agonist	NNS
cord-005941-e4fvj54l	494	21	.	.	.
cord-005941-e4fvj54l	495	1	Ambroxol	Ambroxol	NNP
cord-005941-e4fvj54l	495	2	,	,	,
cord-005941-e4fvj54l	495	3	a	a	DT
cord-005941-e4fvj54l	495	4	drug	drug	NN
cord-005941-e4fvj54l	495	5	which	which	WDT
cord-005941-e4fvj54l	495	6	is	be	VBZ
cord-005941-e4fvj54l	495	7	primarily	primarily	RB
cord-005941-e4fvj54l	495	8	marketed	market	VBN
cord-005941-e4fvj54l	495	9	as	as	IN
cord-005941-e4fvj54l	495	10	a	a	DT
cord-005941-e4fvj54l	495	11	mucolytic	mucolytic	JJ
cord-005941-e4fvj54l	495	12	agent	agent	NN
cord-005941-e4fvj54l	495	13	,	,	,
cord-005941-e4fvj54l	495	14	seems	seem	VBZ
cord-005941-e4fvj54l	495	15	to	to	TO
cord-005941-e4fvj54l	495	16	enhance	enhance	VB
cord-005941-e4fvj54l	495	17	surfactant	surfactant	NN
cord-005941-e4fvj54l	495	18	production	production	NN
cord-005941-e4fvj54l	495	19	and	and	CC
cord-005941-e4fvj54l	495	20	secretion	secretion	NN
cord-005941-e4fvj54l	495	21	[	[	-LRB-
cord-005941-e4fvj54l	495	22	32	32	CD
cord-005941-e4fvj54l	495	23	,	,	,
cord-005941-e4fvj54l	495	24	147	147	CD
cord-005941-e4fvj54l	495	25	]	]	-RRB-
cord-005941-e4fvj54l	495	26	and	and	CC
cord-005941-e4fvj54l	495	27	has	have	VBZ
cord-005941-e4fvj54l	495	28	been	be	VBN
cord-005941-e4fvj54l	495	29	reported	report	VBN
cord-005941-e4fvj54l	495	30	to	to	TO
cord-005941-e4fvj54l	495	31	be	be	VB
cord-005941-e4fvj54l	495	32	useful	useful	JJ
cord-005941-e4fvj54l	495	33	for	for	IN
cord-005941-e4fvj54l	495	34	the	the	DT
cord-005941-e4fvj54l	495	35	prevention	prevention	NN
cord-005941-e4fvj54l	495	36	and	and	CC
cord-005941-e4fvj54l	495	37	treatment	treatment	NN
cord-005941-e4fvj54l	495	38	of	of	IN
cord-005941-e4fvj54l	495	39	IRDS	IRDS	NNP
cord-005941-e4fvj54l	495	40	(	(	-LRB-
cord-005941-e4fvj54l	495	41	for	for	IN
cord-005941-e4fvj54l	495	42	review	review	NN
cord-005941-e4fvj54l	495	43	see	see	VB
cord-005941-e4fvj54l	495	44	[	[	-LRB-
cord-005941-e4fvj54l	495	45	125	125	CD
cord-005941-e4fvj54l	495	46	]	]	-RRB-
cord-005941-e4fvj54l	495	47	)	)	-RRB-
cord-005941-e4fvj54l	495	48	.	.	.
cord-005941-e4fvj54l	496	1	We	-PRON-	PRP
cord-005941-e4fvj54l	496	2	were	be	VBD
cord-005941-e4fvj54l	496	3	not	not	RB
cord-005941-e4fvj54l	496	4	able	able	JJ
cord-005941-e4fvj54l	496	5	to	to	TO
cord-005941-e4fvj54l	496	6	find	find	VB
cord-005941-e4fvj54l	496	7	studies	study	NNS
cord-005941-e4fvj54l	496	8	investigating	investigate	VBG
cord-005941-e4fvj54l	496	9	a	a	DT
cord-005941-e4fvj54l	496	10	potential	potential	JJ
cord-005941-e4fvj54l	496	11	use	use	NN
cord-005941-e4fvj54l	496	12	of	of	IN
cord-005941-e4fvj54l	496	13	ambroxol	ambroxol	NN
cord-005941-e4fvj54l	496	14	in	in	IN
cord-005941-e4fvj54l	496	15	ARDS	ARDS	NNP
cord-005941-e4fvj54l	496	16	.	.	.
cord-005941-e4fvj54l	497	1	This	this	DT
cord-005941-e4fvj54l	497	2	review	review	NN
cord-005941-e4fvj54l	497	3	has	have	VBZ
cord-005941-e4fvj54l	497	4	attempted	attempt	VBN
cord-005941-e4fvj54l	497	5	to	to	TO
cord-005941-e4fvj54l	497	6	summarize	summarize	VB
cord-005941-e4fvj54l	497	7	briefly	briefly	RB
cord-005941-e4fvj54l	497	8	the	the	DT
cord-005941-e4fvj54l	497	9	present	present	JJ
cord-005941-e4fvj54l	497	10	knowledge	knowledge	NN
cord-005941-e4fvj54l	497	11	on	on	IN
cord-005941-e4fvj54l	497	12	the	the	DT
cord-005941-e4fvj54l	497	13	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	497	14	surfactant	surfactant	NN
cord-005941-e4fvj54l	497	15	system	system	NN
cord-005941-e4fvj54l	497	16	and	and	CC
cord-005941-e4fvj54l	497	17	has	have	VBZ
cord-005941-e4fvj54l	497	18	tried	try	VBN
cord-005941-e4fvj54l	497	19	to	to	TO
cord-005941-e4fvj54l	497	20	outline	outline	VB
cord-005941-e4fvj54l	497	21	some	some	DT
cord-005941-e4fvj54l	497	22	of	of	IN
cord-005941-e4fvj54l	497	23	the	the	DT
cord-005941-e4fvj54l	497	24	available	available	JJ
cord-005941-e4fvj54l	497	25	information	information	NN
cord-005941-e4fvj54l	497	26	which	which	WDT
cord-005941-e4fvj54l	497	27	may	may	MD
cord-005941-e4fvj54l	497	28	in	in	IN
cord-005941-e4fvj54l	497	29	the	the	DT
cord-005941-e4fvj54l	497	30	future	future	NN
cord-005941-e4fvj54l	497	31	become	become	VBP
cord-005941-e4fvj54l	497	32	relevant	relevant	JJ
cord-005941-e4fvj54l	497	33	to	to	IN
cord-005941-e4fvj54l	497	34	clinical	clinical	JJ
cord-005941-e4fvj54l	497	35	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	497	36	medicine	medicine	NN
cord-005941-e4fvj54l	497	37	.	.	.
cord-005941-e4fvj54l	498	1	After	after	IN
cord-005941-e4fvj54l	498	2	more	more	JJR
cord-005941-e4fvj54l	498	3	than	than	IN
cord-005941-e4fvj54l	498	4	60	60	CD
cord-005941-e4fvj54l	498	5	years	year	NNS
cord-005941-e4fvj54l	498	6	of	of	IN
cord-005941-e4fvj54l	498	7	research	research	NN
cord-005941-e4fvj54l	498	8	,	,	,
cord-005941-e4fvj54l	498	9	the	the	DT
cord-005941-e4fvj54l	498	10	surfactant	surfactant	NN
cord-005941-e4fvj54l	498	11	system	system	NN
cord-005941-e4fvj54l	498	12	of	of	IN
cord-005941-e4fvj54l	498	13	the	the	DT
cord-005941-e4fvj54l	498	14	human	human	JJ
cord-005941-e4fvj54l	498	15	lung	lung	NN
cord-005941-e4fvj54l	498	16	has	have	VBZ
cord-005941-e4fvj54l	498	17	not	not	RB
cord-005941-e4fvj54l	498	18	yet	yet	RB
cord-005941-e4fvj54l	498	19	become	become	VBN
cord-005941-e4fvj54l	498	20	part	part	NN
cord-005941-e4fvj54l	498	21	of	of	IN
cord-005941-e4fvj54l	498	22	routine	routine	JJ
cord-005941-e4fvj54l	498	23	diagnostic	diagnostic	JJ
cord-005941-e4fvj54l	498	24	or	or	CC
cord-005941-e4fvj54l	498	25	therapeutic	therapeutic	JJ
cord-005941-e4fvj54l	498	26	considerations	consideration	NNS
cord-005941-e4fvj54l	498	27	in	in	IN
cord-005941-e4fvj54l	498	28	adult	adult	JJ
cord-005941-e4fvj54l	498	29	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	498	30	medicine	medicine	NN
cord-005941-e4fvj54l	498	31	.	.	.
cord-005941-e4fvj54l	499	1	However	however	RB
cord-005941-e4fvj54l	499	2	,	,	,
cord-005941-e4fvj54l	499	3	with	with	IN
cord-005941-e4fvj54l	499	4	growing	grow	VBG
cord-005941-e4fvj54l	499	5	knowledge	knowledge	NN
cord-005941-e4fvj54l	499	6	from	from	IN
cord-005941-e4fvj54l	499	7	basic	basic	JJ
cord-005941-e4fvj54l	499	8	research	research	NN
cord-005941-e4fvj54l	499	9	,	,	,
cord-005941-e4fvj54l	499	10	surfactant	surfactant	NN
cord-005941-e4fvj54l	499	11	studies	study	NNS
cord-005941-e4fvj54l	499	12	are	be	VBP
cord-005941-e4fvj54l	499	13	beginning	begin	VBG
cord-005941-e4fvj54l	499	14	to	to	TO
cord-005941-e4fvj54l	499	15	give	give	VB
cord-005941-e4fvj54l	499	16	us	-PRON-	PRP
cord-005941-e4fvj54l	499	17	some	some	DT
cord-005941-e4fvj54l	499	18	new	new	JJ
cord-005941-e4fvj54l	499	19	insights	insight	NNS
cord-005941-e4fvj54l	499	20	into	into	IN
cord-005941-e4fvj54l	499	21	the	the	DT
cord-005941-e4fvj54l	499	22	mechanisms	mechanism	NNS
cord-005941-e4fvj54l	499	23	involved	involve	VBN
cord-005941-e4fvj54l	499	24	in	in	IN
cord-005941-e4fvj54l	499	25	various	various	JJ
cord-005941-e4fvj54l	499	26	lung	lung	NN
cord-005941-e4fvj54l	499	27	diseases	disease	NNS
cord-005941-e4fvj54l	499	28	and	and	CC
cord-005941-e4fvj54l	499	29	in	in	IN
cord-005941-e4fvj54l	499	30	the	the	DT
cord-005941-e4fvj54l	499	31	degree	degree	NN
cord-005941-e4fvj54l	499	32	of	of	IN
cord-005941-e4fvj54l	499	33	involvement	involvement	NN
cord-005941-e4fvj54l	499	34	of	of	IN
cord-005941-e4fvj54l	499	35	alveolar	alveolar	JJ
cord-005941-e4fvj54l	499	36	type	type	NN
cord-005941-e4fvj54l	499	37	II	ii	CD
cord-005941-e4fvj54l	499	38	cells	cell	NNS
cord-005941-e4fvj54l	499	39	.	.	.
cord-005941-e4fvj54l	500	1	Thus	thus	RB
cord-005941-e4fvj54l	500	2	,	,	,
cord-005941-e4fvj54l	500	3	a	a	DT
cord-005941-e4fvj54l	500	4	variety	variety	NN
cord-005941-e4fvj54l	500	5	of	of	IN
cord-005941-e4fvj54l	500	6	possible	possible	JJ
cord-005941-e4fvj54l	500	7	perspectives	perspective	NNS
cord-005941-e4fvj54l	500	8	have	have	VBP
cord-005941-e4fvj54l	500	9	now	now	RB
cord-005941-e4fvj54l	500	10	arisen	arise	VBN
cord-005941-e4fvj54l	500	11	,	,	,
cord-005941-e4fvj54l	500	12	ranging	range	VBG
cord-005941-e4fvj54l	500	13	from	from	IN
cord-005941-e4fvj54l	500	14	diagnostic	diagnostic	JJ
cord-005941-e4fvj54l	500	15	to	to	IN
cord-005941-e4fvj54l	500	16	therapeutic	therapeutic	JJ
cord-005941-e4fvj54l	500	17	implications	implication	NNS
cord-005941-e4fvj54l	500	18	and	and	CC
cord-005941-e4fvj54l	500	19	preventional	preventional	JJ
cord-005941-e4fvj54l	500	20	aspects	aspect	NNS
cord-005941-e4fvj54l	500	21	.	.	.
cord-005941-e4fvj54l	501	1	It	-PRON-	PRP
cord-005941-e4fvj54l	501	2	does	do	VBZ
cord-005941-e4fvj54l	501	3	not	not	RB
cord-005941-e4fvj54l	501	4	seem	seem	VB
cord-005941-e4fvj54l	501	5	likely	likely	JJ
cord-005941-e4fvj54l	501	6	that	that	IN
cord-005941-e4fvj54l	501	7	surfactant	surfactant	NN
cord-005941-e4fvj54l	501	8	analyses	analysis	NNS
cord-005941-e4fvj54l	501	9	will	will	MD
cord-005941-e4fvj54l	501	10	in	in	IN
cord-005941-e4fvj54l	501	11	the	the	DT
cord-005941-e4fvj54l	501	12	future	future	NN
cord-005941-e4fvj54l	501	13	be	be	VB
cord-005941-e4fvj54l	501	14	used	use	VBN
cord-005941-e4fvj54l	501	15	primarily	primarily	RB
cord-005941-e4fvj54l	501	16	to	to	TO
cord-005941-e4fvj54l	501	17	arrive	arrive	VB
cord-005941-e4fvj54l	501	18	at	at	IN
cord-005941-e4fvj54l	501	19	a	a	DT
cord-005941-e4fvj54l	501	20	specific	specific	JJ
cord-005941-e4fvj54l	501	21	diagnosis	diagnosis	NN
cord-005941-e4fvj54l	501	22	of	of	IN
cord-005941-e4fvj54l	501	23	a	a	DT
cord-005941-e4fvj54l	501	24	disease	disease	NN
cord-005941-e4fvj54l	501	25	since	since	IN
cord-005941-e4fvj54l	501	26	there	there	EX
cord-005941-e4fvj54l	501	27	are	be	VBP
cord-005941-e4fvj54l	501	28	probably	probably	RB
cord-005941-e4fvj54l	501	29	not	not	RB
cord-005941-e4fvj54l	501	30	many	many	JJ
cord-005941-e4fvj54l	501	31	conditions	condition	NNS
cord-005941-e4fvj54l	501	32	which	which	WDT
cord-005941-e4fvj54l	501	33	feature	feature	VBP
cord-005941-e4fvj54l	501	34	characteristic	characteristic	JJ
cord-005941-e4fvj54l	501	35	surfactant	surfactant	NN
cord-005941-e4fvj54l	501	36	abnormalities	abnormality	NNS
cord-005941-e4fvj54l	501	37	.	.	.
cord-005941-e4fvj54l	502	1	However	however	RB
cord-005941-e4fvj54l	502	2	,	,	,
cord-005941-e4fvj54l	502	3	present	present	JJ
cord-005941-e4fvj54l	502	4	evidence	evidence	NN
cord-005941-e4fvj54l	502	5	fosters	foster	VBZ
cord-005941-e4fvj54l	502	6	speculations	speculation	NNS
cord-005941-e4fvj54l	502	7	that	that	IN
cord-005941-e4fvj54l	502	8	surfactant	surfactant	NN
cord-005941-e4fvj54l	502	9	studies	study	NNS
cord-005941-e4fvj54l	502	10	may	may	MD
cord-005941-e4fvj54l	502	11	prove	prove	VB
cord-005941-e4fvj54l	502	12	useful	useful	JJ
cord-005941-e4fvj54l	502	13	in	in	IN
cord-005941-e4fvj54l	502	14	giving	give	VBG
cord-005941-e4fvj54l	502	15	some	some	DT
cord-005941-e4fvj54l	502	16	information	information	NN
cord-005941-e4fvj54l	502	17	about	about	IN
cord-005941-e4fvj54l	502	18	the	the	DT
cord-005941-e4fvj54l	502	19	activity	activity	NN
cord-005941-e4fvj54l	502	20	,	,	,
cord-005941-e4fvj54l	502	21	intensity	intensity	NN
cord-005941-e4fvj54l	502	22	,	,	,
cord-005941-e4fvj54l	502	23	and	and	CC
cord-005941-e4fvj54l	502	24	perhaps	perhaps	RB
cord-005941-e4fvj54l	502	25	the	the	DT
cord-005941-e4fvj54l	502	26	duration	duration	NN
cord-005941-e4fvj54l	502	27	of	of	IN
cord-005941-e4fvj54l	502	28	some	some	DT
cord-005941-e4fvj54l	502	29	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	502	30	diseases	disease	NNS
cord-005941-e4fvj54l	502	31	or	or	CC
cord-005941-e4fvj54l	502	32	pollutant	pollutant	NN
cord-005941-e4fvj54l	502	33	exposure	exposure	NN
cord-005941-e4fvj54l	502	34	,	,	,
cord-005941-e4fvj54l	502	35	and	and	CC
cord-005941-e4fvj54l	502	36	they	-PRON-	PRP
cord-005941-e4fvj54l	502	37	may	may	MD
cord-005941-e4fvj54l	502	38	be	be	VB
cord-005941-e4fvj54l	502	39	found	find	VBN
cord-005941-e4fvj54l	502	40	helpful	helpful	JJ
cord-005941-e4fvj54l	502	41	in	in	IN
cord-005941-e4fvj54l	502	42	the	the	DT
cord-005941-e4fvj54l	502	43	differential	differential	JJ
cord-005941-e4fvj54l	502	44	diagnosis	diagnosis	NN
cord-005941-e4fvj54l	502	45	of	of	IN
cord-005941-e4fvj54l	502	46	fibrosing	fibrose	VBG
cord-005941-e4fvj54l	502	47	lung	lung	NN
cord-005941-e4fvj54l	502	48	disease	disease	NN
cord-005941-e4fvj54l	502	49	.	.	.
cord-005941-e4fvj54l	503	1	Furthermore	furthermore	RB
cord-005941-e4fvj54l	503	2	,	,	,
cord-005941-e4fvj54l	503	3	it	-PRON-	PRP
cord-005941-e4fvj54l	503	4	can	can	MD
cord-005941-e4fvj54l	503	5	be	be	VB
cord-005941-e4fvj54l	503	6	speculated	speculate	VBN
cord-005941-e4fvj54l	503	7	that	that	IN
cord-005941-e4fvj54l	503	8	surfactant	surfactant	NN
cord-005941-e4fvj54l	503	9	studies	study	NNS
cord-005941-e4fvj54l	503	10	may	may	MD
cord-005941-e4fvj54l	503	11	help	help	VB
cord-005941-e4fvj54l	503	12	to	to	TO
cord-005941-e4fvj54l	503	13	monitor	monitor	VB
cord-005941-e4fvj54l	503	14	the	the	DT
cord-005941-e4fvj54l	503	15	effects	effect	NNS
cord-005941-e4fvj54l	503	16	of	of	IN
cord-005941-e4fvj54l	503	17	therapies	therapy	NNS
cord-005941-e4fvj54l	503	18	and	and	CC
cord-005941-e4fvj54l	503	19	to	to	TO
cord-005941-e4fvj54l	503	20	assess	assess	VB
cord-005941-e4fvj54l	503	21	the	the	DT
cord-005941-e4fvj54l	503	22	prognosis	prognosis	NN
cord-005941-e4fvj54l	503	23	of	of	IN
cord-005941-e4fvj54l	503	24	various	various	JJ
cord-005941-e4fvj54l	503	25	lung	lung	NN
cord-005941-e4fvj54l	503	26	diseases	disease	NNS
cord-005941-e4fvj54l	503	27	.	.	.
cord-005941-e4fvj54l	504	1	However	however	RB
cord-005941-e4fvj54l	504	2	,	,	,
cord-005941-e4fvj54l	504	3	much	much	RB
cord-005941-e4fvj54l	504	4	more	more	JJR
cord-005941-e4fvj54l	504	5	work	work	NN
cord-005941-e4fvj54l	504	6	has	have	VBZ
cord-005941-e4fvj54l	504	7	to	to	TO
cord-005941-e4fvj54l	504	8	be	be	VB
cord-005941-e4fvj54l	504	9	done	do	VBN
cord-005941-e4fvj54l	504	10	to	to	TO
cord-005941-e4fvj54l	504	11	investigate	investigate	VB
cord-005941-e4fvj54l	504	12	these	these	DT
cord-005941-e4fvj54l	504	13	hypotheses	hypothesis	NNS
cord-005941-e4fvj54l	504	14	,	,	,
cord-005941-e4fvj54l	504	15	and	and	CC
cord-005941-e4fvj54l	504	16	possible	possible	JJ
cord-005941-e4fvj54l	504	17	useful	useful	JJ
cord-005941-e4fvj54l	504	18	results	result	NNS
cord-005941-e4fvj54l	504	19	will	will	MD
cord-005941-e4fvj54l	504	20	have	have	VB
cord-005941-e4fvj54l	504	21	to	to	TO
cord-005941-e4fvj54l	504	22	be	be	VB
cord-005941-e4fvj54l	504	23	weighed	weigh	VBN
cord-005941-e4fvj54l	504	24	against	against	IN
cord-005941-e4fvj54l	504	25	the	the	DT
cord-005941-e4fvj54l	504	26	established	establish	VBN
cord-005941-e4fvj54l	504	27	clinical	clinical	JJ
cord-005941-e4fvj54l	504	28	tools	tool	NNS
cord-005941-e4fvj54l	504	29	.	.	.
cord-005941-e4fvj54l	505	1	Therapeutic	therapeutic	JJ
cord-005941-e4fvj54l	505	2	perspectives	perspective	NNS
cord-005941-e4fvj54l	505	3	are	be	VBP
cord-005941-e4fvj54l	505	4	at	at	IN
cord-005941-e4fvj54l	505	5	present	present	JJ
cord-005941-e4fvj54l	505	6	mainly	mainly	RB
cord-005941-e4fvj54l	505	7	focussed	focusse	VBN
cord-005941-e4fvj54l	505	8	on	on	IN
cord-005941-e4fvj54l	505	9	ARDS	ARDS	NNP
cord-005941-e4fvj54l	505	10	.	.	.
cord-005941-e4fvj54l	506	1	Here	here	RB
cord-005941-e4fvj54l	506	2	,	,	,
cord-005941-e4fvj54l	506	3	the	the	DT
cord-005941-e4fvj54l	506	4	first	first	JJ
cord-005941-e4fvj54l	506	5	results	result	NNS
cord-005941-e4fvj54l	506	6	of	of	IN
cord-005941-e4fvj54l	506	7	clinical	clinical	JJ
cord-005941-e4fvj54l	506	8	trials	trial	NNS
cord-005941-e4fvj54l	506	9	will	will	MD
cord-005941-e4fvj54l	506	10	soon	soon	RB
cord-005941-e4fvj54l	506	11	be	be	VB
cord-005941-e4fvj54l	506	12	available	available	JJ
cord-005941-e4fvj54l	506	13	and	and	CC
cord-005941-e4fvj54l	506	14	are	be	VBP
cord-005941-e4fvj54l	506	15	awaited	await	VBN
cord-005941-e4fvj54l	506	16	with	with	IN
cord-005941-e4fvj54l	506	17	interest	interest	NN
cord-005941-e4fvj54l	506	18	.	.	.
cord-005941-e4fvj54l	507	1	Other	other	JJ
cord-005941-e4fvj54l	507	2	indications	indication	NNS
cord-005941-e4fvj54l	507	3	of	of	IN
cord-005941-e4fvj54l	507	4	surfactant	surfactant	NN
cord-005941-e4fvj54l	507	5	therapy	therapy	NN
cord-005941-e4fvj54l	507	6	are	be	VBP
cord-005941-e4fvj54l	507	7	not	not	RB
cord-005941-e4fvj54l	507	8	yet	yet	RB
cord-005941-e4fvj54l	507	9	clearly	clearly	RB
cord-005941-e4fvj54l	507	10	visible	visible	JJ
cord-005941-e4fvj54l	507	11	and	and	CC
cord-005941-e4fvj54l	507	12	remain	remain	VBP
cord-005941-e4fvj54l	507	13	highly	highly	RB
cord-005941-e4fvj54l	507	14	speculative	speculative	JJ
cord-005941-e4fvj54l	507	15	.	.	.
cord-005941-e4fvj54l	508	1	However	however	RB
cord-005941-e4fvj54l	508	2	,	,	,
cord-005941-e4fvj54l	508	3	the	the	DT
cord-005941-e4fvj54l	508	4	known	know	VBN
cord-005941-e4fvj54l	508	5	role	role	NN
cord-005941-e4fvj54l	508	6	of	of	IN
cord-005941-e4fvj54l	508	7	the	the	DT
cord-005941-e4fvj54l	508	8	surfactant	surfactant	NN
cord-005941-e4fvj54l	508	9	system	system	NN
cord-005941-e4fvj54l	508	10	in	in	IN
cord-005941-e4fvj54l	508	11	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	508	12	host	host	NN
cord-005941-e4fvj54l	508	13	defense	defense	NN
cord-005941-e4fvj54l	508	14	mechanisms	mechanism	NNS
cord-005941-e4fvj54l	508	15	and	and	CC
cord-005941-e4fvj54l	508	16	local	local	JJ
cord-005941-e4fvj54l	508	17	immunomodulation	immunomodulation	NN
cord-005941-e4fvj54l	508	18	will	will	MD
cord-005941-e4fvj54l	508	19	continue	continue	VB
cord-005941-e4fvj54l	508	20	to	to	TO
cord-005941-e4fvj54l	508	21	stimulate	stimulate	VB
cord-005941-e4fvj54l	508	22	clinical	clinical	JJ
cord-005941-e4fvj54l	508	23	interest	interest	NN
cord-005941-e4fvj54l	508	24	in	in	IN
cord-005941-e4fvj54l	508	25	its	-PRON-	PRP$
cord-005941-e4fvj54l	508	26	role	role	NN
cord-005941-e4fvj54l	508	27	in	in	IN
cord-005941-e4fvj54l	508	28	inflammatory	inflammatory	JJ
cord-005941-e4fvj54l	508	29	and	and	CC
cord-005941-e4fvj54l	508	30	immunologic	immunologic	JJ
cord-005941-e4fvj54l	508	31	disorders	disorder	NNS
cord-005941-e4fvj54l	508	32	of	of	IN
cord-005941-e4fvj54l	508	33	the	the	DT
cord-005941-e4fvj54l	508	34	lung	lung	NN
cord-005941-e4fvj54l	508	35	.	.	.
cord-005941-e4fvj54l	509	1	Surfactant	surfactant	NN
cord-005941-e4fvj54l	509	2	in	in	IN
cord-005941-e4fvj54l	509	3	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	509	4	oxygen	oxygen	NN
cord-005941-e4fvj54l	509	5	toxicity	toxicity	NN
cord-005941-e4fvj54l	509	6	Long	long	JJ
cord-005941-e4fvj54l	509	7	-	-	HYPH
cord-005941-e4fvj54l	509	8	term	term	NN
cord-005941-e4fvj54l	509	9	nitrogen	nitrogen	NN
cord-005941-e4fvj54l	509	10	dioxide	dioxide	NN
cord-005941-e4fvj54l	509	11	exposure	exposure	NN
cord-005941-e4fvj54l	509	12	Surfactant	Surfactant	NNP
cord-005941-e4fvj54l	509	13	apoprotein	apoprotein	NNP
cord-005941-e4fvj54l	509	14	A	A	NNP
cord-005941-e4fvj54l	509	15	(	(	-LRB-
cord-005941-e4fvj54l	509	16	SP	SP	NNP
cord-005941-e4fvj54l	509	17	-	-	HYPH
cord-005941-e4fvj54l	509	18	A	A	NNP
cord-005941-e4fvj54l	509	19	)	)	-RRB-
cord-005941-e4fvj54l	509	20	is	be	VBZ
cord-005941-e4fvj54l	509	21	synthesized	synthesize	VBN
cord-005941-e4fvj54l	509	22	in	in	IN
cord-005941-e4fvj54l	509	23	airway	airway	NN
cord-005941-e4fvj54l	509	24	cells	cell	NNS
cord-005941-e4fvj54l	509	25	Surface	surface	NN
cord-005941-e4fvj54l	509	26	properties	property	NNS
cord-005941-e4fvj54l	509	27	in	in	IN
cord-005941-e4fvj54l	509	28	relation	relation	NN
cord-005941-e4fvj54l	509	29	to	to	IN
cord-005941-e4fvj54l	509	30	atelectasis	atelectasis	NN
cord-005941-e4fvj54l	509	31	and	and	CC
cord-005941-e4fvj54l	509	32	hyaline	hyaline	JJ
cord-005941-e4fvj54l	509	33	membrane	membrane	NN
cord-005941-e4fvj54l	509	34	disease	disease	NN
cord-005941-e4fvj54l	509	35	Surfactant	Surfactant	NNP
cord-005941-e4fvj54l	509	36	protein	protein	NN
cord-005941-e4fvj54l	509	37	SP	SP	NNP
cord-005941-e4fvj54l	509	38	-	-	HYPH
cord-005941-e4fvj54l	509	39	B	B	NNP
cord-005941-e4fvj54l	509	40	induces	induce	VBZ
cord-005941-e4fvj54l	509	41	ordering	order	VBG
cord-005941-e4fvj54l	509	42	at	at	IN
cord-005941-e4fvj54l	509	43	the	the	DT
cord-005941-e4fvj54l	509	44	surface	surface	NN
cord-005941-e4fvj54l	509	45	of	of	IN
cord-005941-e4fvj54l	509	46	model	model	NN
cord-005941-e4fvj54l	509	47	membrane	membrane	NN
cord-005941-e4fvj54l	509	48	bilayers	bilayer	NNS
cord-005941-e4fvj54l	510	1	Ozone	ozone	NN
cord-005941-e4fvj54l	510	2	stress	stress	NN
cord-005941-e4fvj54l	510	3	initiates	initiate	VBZ
cord-005941-e4fvj54l	510	4	acute	acute	JJ
cord-005941-e4fvj54l	510	5	perturbations	perturbation	NNS
cord-005941-e4fvj54l	510	6	of	of	IN
cord-005941-e4fvj54l	510	7	secreted	secrete	VBN
cord-005941-e4fvj54l	510	8	surfactant	surfactant	NN
cord-005941-e4fvj54l	510	9	membranes	membrane	NNS
cord-005941-e4fvj54l	510	10	Hormonal	hormonal	JJ
cord-005941-e4fvj54l	510	11	regulation	regulation	NN
cord-005941-e4fvj54l	510	12	of	of	IN
cord-005941-e4fvj54l	510	13	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	510	14	surfactant	surfactant	NN
cord-005941-e4fvj54l	510	15	Chemical	Chemical	NNP
cord-005941-e4fvj54l	510	16	structure	structure	NN
cord-005941-e4fvj54l	510	17	of	of	IN
cord-005941-e4fvj54l	510	18	phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	510	19	in	in	IN
cord-005941-e4fvj54l	510	20	the	the	DT
cord-005941-e4fvj54l	510	21	lungs	lung	NNS
cord-005941-e4fvj54l	510	22	and	and	CC
cord-005941-e4fvj54l	510	23	airways	airway	NNS
cord-005941-e4fvj54l	510	24	of	of	IN
cord-005941-e4fvj54l	510	25	sheep	sheep	NNP
cord-005941-e4fvj54l	510	26	Surface	Surface	NNP
cord-005941-e4fvj54l	510	27	tension	tension	NN
cord-005941-e4fvj54l	510	28	induced	induce	VBN
cord-005941-e4fvj54l	510	29	by	by	IN
cord-005941-e4fvj54l	510	30	dipalmitoyl	dipalmitoyl	NNP
cord-005941-e4fvj54l	510	31	lecithin	lecithin	NN
cord-005941-e4fvj54l	510	32	in	in	IN
cord-005941-e4fvj54l	510	33	vitro	vitro	FW
cord-005941-e4fvj54l	510	34	under	under	IN
cord-005941-e4fvj54l	510	35	physiological	physiological	JJ
cord-005941-e4fvj54l	510	36	conditions	condition	NNS
cord-005941-e4fvj54l	510	37	Lung	Lung	NNP
cord-005941-e4fvj54l	510	38	derived	derive	VBN
cord-005941-e4fvj54l	510	39	surface	surface	NN
cord-005941-e4fvj54l	510	40	active	active	JJ
cord-005941-e4fvj54l	510	41	material	material	NN
cord-005941-e4fvj54l	510	42	(	(	-LRB-
cord-005941-e4fvj54l	510	43	SAM	SAM	NNP
cord-005941-e4fvj54l	510	44	)	)	-RRB-
cord-005941-e4fvj54l	510	45	inhibits	inhibit	VBZ
cord-005941-e4fvj54l	511	1	natural	natural	JJ
cord-005941-e4fvj54l	511	2	killer	killer	NN
cord-005941-e4fvj54l	511	3	cell	cell	NN
cord-005941-e4fvj54l	511	4	tumor	tumor	NN
cord-005941-e4fvj54l	511	5	cytotoxicity	cytotoxicity	NN
cord-005941-e4fvj54l	511	6	Changes	change	NNS
cord-005941-e4fvj54l	511	7	in	in	IN
cord-005941-e4fvj54l	511	8	fatty	fatty	JJ
cord-005941-e4fvj54l	511	9	acids	acid	NNS
cord-005941-e4fvj54l	511	10	in	in	IN
cord-005941-e4fvj54l	511	11	phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	511	12	of	of	IN
cord-005941-e4fvj54l	511	13	the	the	DT
cord-005941-e4fvj54l	511	14	bronchoalveolar	bronchoalveolar	JJ
cord-005941-e4fvj54l	511	15	fluid	fluid	NN
cord-005941-e4fvj54l	511	16	in	in	IN
cord-005941-e4fvj54l	511	17	bacterial	bacterial	JJ
cord-005941-e4fvj54l	511	18	pneumonia	pneumonia	NN
cord-005941-e4fvj54l	511	19	and	and	CC
cord-005941-e4fvj54l	511	20	in	in	IN
cord-005941-e4fvj54l	511	21	adult	adult	JJ
cord-005941-e4fvj54l	511	22	respiratory	respiratory	JJ
cord-005941-e4fvj54l	511	23	distress	distress	NN
cord-005941-e4fvj54l	511	24	syndrome	syndrome	NN
cord-005941-e4fvj54l	511	25	Decreased	decrease	VBD
cord-005941-e4fvj54l	511	26	phosphatidylcholine	phosphatidylcholine	NN
cord-005941-e4fvj54l	511	27	in	in	IN
cord-005941-e4fvj54l	511	28	the	the	DT
cord-005941-e4fvj54l	511	29	lung	lung	NN
cord-005941-e4fvj54l	511	30	fluid	fluid	NN
cord-005941-e4fvj54l	511	31	of	of	IN
cord-005941-e4fvj54l	511	32	patients	patient	NNS
cord-005941-e4fvj54l	511	33	with	with	IN
cord-005941-e4fvj54l	511	34	sarcoidosis	sarcoidosis	NNP
cord-005941-e4fvj54l	511	35	Enhancement	Enhancement	NNP
cord-005941-e4fvj54l	511	36	of	of	IN
cord-005941-e4fvj54l	511	37	macrophage	macrophage	NN
cord-005941-e4fvj54l	511	38	and	and	CC
cord-005941-e4fvj54l	511	39	monocyte	monocyte	NN
cord-005941-e4fvj54l	511	40	cytotoxicity	cytotoxicity	NN
cord-005941-e4fvj54l	511	41	by	by	IN
cord-005941-e4fvj54l	511	42	the	the	DT
cord-005941-e4fvj54l	511	43	surface	surface	NN
cord-005941-e4fvj54l	511	44	active	active	JJ
cord-005941-e4fvj54l	511	45	material	material	NN
cord-005941-e4fvj54l	511	46	of	of	IN
cord-005941-e4fvj54l	511	47	lung	lung	NN
cord-005941-e4fvj54l	511	48	lining	lining	NN
cord-005941-e4fvj54l	511	49	fluid	fluid	JJ
cord-005941-e4fvj54l	511	50	Sequential	sequential	JJ
cord-005941-e4fvj54l	511	51	changes	change	NNS
cord-005941-e4fvj54l	511	52	in	in	IN
cord-005941-e4fvj54l	511	53	phospholipid	phospholipid	NN
cord-005941-e4fvj54l	511	54	composition	composition	NN
cord-005941-e4fvj54l	511	55	and	and	CC
cord-005941-e4fvj54l	511	56	synthesis	synthesis	NN
cord-005941-e4fvj54l	511	57	in	in	IN
cord-005941-e4fvj54l	511	58	lungs	lung	NNS
cord-005941-e4fvj54l	511	59	exposed	expose	VBN
cord-005941-e4fvj54l	511	60	to	to	IN
cord-005941-e4fvj54l	511	61	nitrogen	nitrogen	NN
cord-005941-e4fvj54l	511	62	dioxide	dioxide	NN
cord-005941-e4fvj54l	511	63	Structure	structure	NN
cord-005941-e4fvj54l	511	64	and	and	CC
cord-005941-e4fvj54l	511	65	function	function	NN
cord-005941-e4fvj54l	511	66	of	of	IN
cord-005941-e4fvj54l	511	67	phosphatidylglycerol	phosphatidylglycerol	JJ
cord-005941-e4fvj54l	511	68	-	-	HYPH
cord-005941-e4fvj54l	511	69	deficient	deficient	JJ
cord-005941-e4fvj54l	511	70	lung	lung	NN
cord-005941-e4fvj54l	511	71	surfactant	surfactant	NN
cord-005941-e4fvj54l	511	72	Toxicity	toxicity	NN
cord-005941-e4fvj54l	511	73	of	of	IN
cord-005941-e4fvj54l	511	74	inhaled	inhale	VBN
cord-005941-e4fvj54l	511	75	cadmium	cadmium	NN
cord-005941-e4fvj54l	511	76	chloride	chloride	NN
cord-005941-e4fvj54l	511	77	:	:	:
cord-005941-e4fvj54l	511	78	early	early	JJ
cord-005941-e4fvj54l	511	79	responses	response	NNS
cord-005941-e4fvj54l	511	80	of	of	IN
cord-005941-e4fvj54l	511	81	the	the	DT
cord-005941-e4fvj54l	511	82	antioxidant	antioxidant	NN
cord-005941-e4fvj54l	511	83	and	and	CC
cord-005941-e4fvj54l	511	84	surfactant	surfactant	NN
cord-005941-e4fvj54l	511	85	systems	system	NNS
cord-005941-e4fvj54l	511	86	in	in	IN
cord-005941-e4fvj54l	511	87	rat	rat	NN
cord-005941-e4fvj54l	511	88	lungs	lung	VBZ
cord-005941-e4fvj54l	511	89	Immunomodulation	Immunomodulation	NNP
cord-005941-e4fvj54l	511	90	by	by	IN
cord-005941-e4fvj54l	511	91	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	511	92	surfactant	surfactant	NN
cord-005941-e4fvj54l	511	93	Regulation	regulation	NN
cord-005941-e4fvj54l	511	94	of	of	IN
cord-005941-e4fvj54l	511	95	lung	lung	NN
cord-005941-e4fvj54l	511	96	surfactant	surfactant	NN
cord-005941-e4fvj54l	511	97	secretion	secretion	NN
cord-005941-e4fvj54l	511	98	Surfacrant	Surfacrant	NNP
cord-005941-e4fvj54l	511	99	proteins	protein	NNS
cord-005941-e4fvj54l	511	100	and	and	CC
cord-005941-e4fvj54l	511	101	anti	anti	JJ
cord-005941-e4fvj54l	511	102	-	-	JJ
cord-005941-e4fvj54l	511	103	surfactant	surfactant	JJ
cord-005941-e4fvj54l	511	104	antibodies	antibody	NNS
cord-005941-e4fvj54l	511	105	in	in	IN
cord-005941-e4fvj54l	511	106	sera	sera	NNP
cord-005941-e4fvj54l	511	107	from	from	IN
cord-005941-e4fvj54l	511	108	infants	infant	NNS
cord-005941-e4fvj54l	511	109	with	with	IN
cord-005941-e4fvj54l	511	110	respiratory	respiratory	JJ
cord-005941-e4fvj54l	511	111	distress	distress	NN
cord-005941-e4fvj54l	511	112	syndrome	syndrome	NN
cord-005941-e4fvj54l	511	113	with	with	IN
cord-005941-e4fvj54l	511	114	and	and	CC
cord-005941-e4fvj54l	511	115	without	without	IN
cord-005941-e4fvj54l	511	116	snrfactant	snrfactant	JJ
cord-005941-e4fvj54l	511	117	treatment	treatment	NN
cord-005941-e4fvj54l	511	118	Surface	Surface	NNP
cord-005941-e4fvj54l	511	119	tension	tension	NN
cord-005941-e4fvj54l	511	120	of	of	IN
cord-005941-e4fvj54l	511	121	lung	lung	NN
cord-005941-e4fvj54l	511	122	extracts	extract	NNS
cord-005941-e4fvj54l	511	123	Smoking	smoking	NN
cord-005941-e4fvj54l	511	124	and	and	CC
cord-005941-e4fvj54l	511	125	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	511	126	surfactant	surfactant	NN
cord-005941-e4fvj54l	511	127	Pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	511	128	surface	surface	NN
cord-005941-e4fvj54l	511	129	tension	tension	NN
cord-005941-e4fvj54l	511	130	and	and	CC
cord-005941-e4fvj54l	511	131	alveolar	alveolar	NN
cord-005941-e4fvj54l	511	132	stability	stability	NN
cord-005941-e4fvj54l	511	133	Pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	511	134	surfactant	surfactant	NN
cord-005941-e4fvj54l	511	135	protein	protein	NN
cord-005941-e4fvj54l	511	136	B	b	NN
cord-005941-e4fvj54l	511	137	(	(	-LRB-
cord-005941-e4fvj54l	511	138	SP	SP	NNP
cord-005941-e4fvj54l	511	139	-	-	HYPH
cord-005941-e4fvj54l	511	140	B	B	NNP
cord-005941-e4fvj54l	511	141	)	)	-RRB-
cord-005941-e4fvj54l	511	142	:	:	:
cord-005941-e4fvj54l	511	143	structure	structure	NN
cord-005941-e4fvj54l	511	144	-	-	HYPH
cord-005941-e4fvj54l	511	145	function	function	NN
cord-005941-e4fvj54l	511	146	relationships	relationship	NNS
cord-005941-e4fvj54l	511	147	Role	role	NN
cord-005941-e4fvj54l	511	148	of	of	IN
cord-005941-e4fvj54l	511	149	surfactant	surfactant	NN
cord-005941-e4fvj54l	511	150	free	free	JJ
cord-005941-e4fvj54l	511	151	fatty	fatty	JJ
cord-005941-e4fvj54l	511	152	acids	acid	NNS
cord-005941-e4fvj54l	511	153	in	in	IN
cord-005941-e4fvj54l	511	154	antimicrobial	antimicrobial	JJ
cord-005941-e4fvj54l	511	155	defenses	defense	NNS
cord-005941-e4fvj54l	511	156	Drug	drug	NN
cord-005941-e4fvj54l	511	157	-	-	HYPH
cord-005941-e4fvj54l	511	158	induced	induce	VBN
cord-005941-e4fvj54l	511	159	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	511	160	disease	disease	NN
cord-005941-e4fvj54l	511	161	.	.	.
cord-005941-e4fvj54l	512	1	Part	part	NN
cord-005941-e4fvj54l	512	2	1	1	CD
cord-005941-e4fvj54l	512	3	:	:	:
cord-005941-e4fvj54l	512	4	cytotoxic	cytotoxic	JJ
cord-005941-e4fvj54l	512	5	drugs	drug	NNS
cord-005941-e4fvj54l	512	6	Drug	drug	NN
cord-005941-e4fvj54l	512	7	-	-	HYPH
cord-005941-e4fvj54l	512	8	induced	induce	VBN
cord-005941-e4fvj54l	512	9	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	512	10	disease	disease	NN
cord-005941-e4fvj54l	512	11	.	.	.
cord-005941-e4fvj54l	513	1	Part	part	NN
cord-005941-e4fvj54l	513	2	2	2	CD
cord-005941-e4fvj54l	513	3	:	:	:
cord-005941-e4fvj54l	514	1	noncytotoxic	noncytotoxic	NNP
cord-005941-e4fvj54l	514	2	drugs	drug	NNS
cord-005941-e4fvj54l	514	3	Decreased	decrease	VBD
cord-005941-e4fvj54l	514	4	mortality	mortality	NN
cord-005941-e4fvj54l	514	5	rate	rate	NN
cord-005941-e4fvj54l	514	6	among	among	IN
cord-005941-e4fvj54l	514	7	small	small	JJ
cord-005941-e4fvj54l	514	8	premature	premature	JJ
cord-005941-e4fvj54l	514	9	infants	infant	NNS
cord-005941-e4fvj54l	514	10	treated	treat	VBN
cord-005941-e4fvj54l	514	11	at	at	IN
cord-005941-e4fvj54l	514	12	birth	birth	NN
cord-005941-e4fvj54l	514	13	with	with	IN
cord-005941-e4fvj54l	514	14	a	a	DT
cord-005941-e4fvj54l	514	15	single	single	JJ
cord-005941-e4fvj54l	514	16	dose	dose	NN
cord-005941-e4fvj54l	514	17	of	of	IN
cord-005941-e4fvj54l	514	18	synthetic	synthetic	JJ
cord-005941-e4fvj54l	514	19	surfactant	surfactant	NN
cord-005941-e4fvj54l	514	20	:	:	:
cord-005941-e4fvj54l	515	1	a	a	DT
cord-005941-e4fvj54l	515	2	multicenter	multicenter	NN
cord-005941-e4fvj54l	515	3	controlled	control	VBN
cord-005941-e4fvj54l	515	4	trial	trial	NN
cord-005941-e4fvj54l	515	5	Lung	Lung	NNP
cord-005941-e4fvj54l	515	6	surfactant	surfactant	NN
cord-005941-e4fvj54l	515	7	associated	associate	VBD
cord-005941-e4fvj54l	515	8	proteins	protein	NNS
cord-005941-e4fvj54l	515	9	and	and	CC
cord-005941-e4fvj54l	515	10	type	type	NN
cord-005941-e4fvj54l	515	11	IV	IV	NNP
cord-005941-e4fvj54l	515	12	collagen	collagen	NN
cord-005941-e4fvj54l	515	13	share	share	VBP
cord-005941-e4fvj54l	515	14	common	common	JJ
cord-005941-e4fvj54l	515	15	epitopes	epitope	NNS
cord-005941-e4fvj54l	516	1	Surfactant	surfactant	NN
cord-005941-e4fvj54l	516	2	protein	protein	NN
cord-005941-e4fvj54l	516	3	D.	D.	NNP
cord-005941-e4fvj54l	516	4	Increased	increase	VBN
cord-005941-e4fvj54l	516	5	accumulation	accumulation	NN
cord-005941-e4fvj54l	516	6	in	in	IN
cord-005941-e4fvj54l	516	7	silica	silica	NN
cord-005941-e4fvj54l	516	8	-	-	HYPH
cord-005941-e4fvj54l	516	9	induced	induce	VBN
cord-005941-e4fvj54l	516	10	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	516	11	lipoproteinosis	lipoproteinosis	NN
cord-005941-e4fvj54l	516	12	Biophysical	biophysical	JJ
cord-005941-e4fvj54l	516	13	alteration	alteration	NN
cord-005941-e4fvj54l	516	14	of	of	IN
cord-005941-e4fvj54l	516	15	lung	lung	NN
cord-005941-e4fvj54l	516	16	surfactant	surfactant	NN
cord-005941-e4fvj54l	516	17	by	by	IN
cord-005941-e4fvj54l	516	18	extracts	extract	NNS
cord-005941-e4fvj54l	516	19	of	of	IN
cord-005941-e4fvj54l	516	20	cotton	cotton	NN
cord-005941-e4fvj54l	516	21	dust	dust	NN
cord-005941-e4fvj54l	516	22	Effects	effect	NNS
cord-005941-e4fvj54l	516	23	of	of	IN
cord-005941-e4fvj54l	516	24	silica	silica	NN
cord-005941-e4fvj54l	516	25	on	on	IN
cord-005941-e4fvj54l	516	26	the	the	DT
cord-005941-e4fvj54l	516	27	composition	composition	NN
cord-005941-e4fvj54l	516	28	of	of	IN
cord-005941-e4fvj54l	516	29	the	the	DT
cord-005941-e4fvj54l	516	30	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	516	31	extracellular	extracellular	JJ
cord-005941-e4fvj54l	516	32	lining	line	VBG
cord-005941-e4fvj54l	516	33	The	the	DT
cord-005941-e4fvj54l	516	34	pharmacology	pharmacology	NN
cord-005941-e4fvj54l	516	35	of	of	IN
cord-005941-e4fvj54l	516	36	ambroxol	ambroxol	NNP
cord-005941-e4fvj54l	516	37	review	review	NN
cord-005941-e4fvj54l	516	38	and	and	CC
cord-005941-e4fvj54l	516	39	new	new	JJ
cord-005941-e4fvj54l	516	40	results	result	NNS
cord-005941-e4fvj54l	516	41	Pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	516	42	surfactant	surfactant	NN
cord-005941-e4fvj54l	516	43	Pulraonary	Pulraonary	NNP
cord-005941-e4fvj54l	516	44	surfactant	surfactant	NN
cord-005941-e4fvj54l	516	45	and	and	CC
cord-005941-e4fvj54l	516	46	its	-PRON-	PRP$
cord-005941-e4fvj54l	516	47	components	component	NNS
cord-005941-e4fvj54l	516	48	inhibit	inhibit	VBP
cord-005941-e4fvj54l	516	49	secretion	secretion	NN
cord-005941-e4fvj54l	516	50	of	of	IN
cord-005941-e4fvj54l	516	51	phosphatidylcholine	phosphatidylcholine	NN
cord-005941-e4fvj54l	516	52	from	from	IN
cord-005941-e4fvj54l	516	53	cultured	cultured	JJ
cord-005941-e4fvj54l	516	54	rat	rat	NN
cord-005941-e4fvj54l	516	55	alveolar	alveolar	NN
cord-005941-e4fvj54l	516	56	type	type	NN
cord-005941-e4fvj54l	516	57	II	ii	CD
cord-005941-e4fvj54l	516	58	cells	cell	NNS
cord-005941-e4fvj54l	516	59	Acute	acute	JJ
cord-005941-e4fvj54l	516	60	tung	tung	NNP
cord-005941-e4fvj54l	516	61	injury	injury	NN
cord-005941-e4fvj54l	516	62	induced	induce	VBN
cord-005941-e4fvj54l	516	63	by	by	IN
cord-005941-e4fvj54l	516	64	phospholipase	phospholipase	NN
cord-005941-e4fvj54l	516	65	A	a	DT
cord-005941-e4fvj54l	516	66	2	2	CD
cord-005941-e4fvj54l	516	67	Surfactant	surfactant	NN
cord-005941-e4fvj54l	516	68	replacement	replacement	NN
cord-005941-e4fvj54l	516	69	in	in	IN
cord-005941-e4fvj54l	516	70	adult	adult	JJ
cord-005941-e4fvj54l	516	71	respiratory	respiratory	JJ
cord-005941-e4fvj54l	516	72	distress	distress	NN
cord-005941-e4fvj54l	516	73	syndrome	syndrome	NN
cord-005941-e4fvj54l	516	74	Pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	516	75	phospholipidosis	phospholipidosis	NN
cord-005941-e4fvj54l	516	76	in	in	IN
cord-005941-e4fvj54l	516	77	rats	rat	NNS
cord-005941-e4fvj54l	516	78	respiring	respire	VBG
cord-005941-e4fvj54l	516	79	air	air	NN
cord-005941-e4fvj54l	516	80	containing	contain	VBG
cord-005941-e4fvj54l	516	81	diesel	diesel	NN
cord-005941-e4fvj54l	516	82	particulates	particulate	NNS
cord-005941-e4fvj54l	516	83	Pathogenesis	Pathogenesis	NNP
cord-005941-e4fvj54l	516	84	of	of	IN
cord-005941-e4fvj54l	516	85	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	516	86	fibrosis	fibrosis	NN
cord-005941-e4fvj54l	516	87	induced	induce	VBN
cord-005941-e4fvj54l	516	88	by	by	IN
cord-005941-e4fvj54l	516	89	chrysotile	chrysotile	NN
cord-005941-e4fvj54l	516	90	asbestos	asbestos	NN
cord-005941-e4fvj54l	516	91	.	.	.
cord-005941-e4fvj54l	517	1	Virchows	Virchows	NNP
cord-005941-e4fvj54l	517	2	Arch	Arch	NNP
cord-005941-e4fvj54l	517	3	Experimental	Experimental	NNP
cord-005941-e4fvj54l	517	4	bleomycin	bleomycin	NN
cord-005941-e4fvj54l	517	5	lung	lung	NN
cord-005941-e4fvj54l	517	6	in	in	IN
cord-005941-e4fvj54l	517	7	mice	mouse	NNS
cord-005941-e4fvj54l	517	8	Physiologic	physiologic	JJ
cord-005941-e4fvj54l	517	9	and	and	CC
cord-005941-e4fvj54l	517	10	toxicologic	toxicologic	JJ
cord-005941-e4fvj54l	517	11	responses	response	NNS
cord-005941-e4fvj54l	517	12	of	of	IN
cord-005941-e4fvj54l	517	13	alveolar	alveolar	JJ
cord-005941-e4fvj54l	517	14	type	type	NN
cord-005941-e4fvj54l	517	15	II	ii	CD
cord-005941-e4fvj54l	517	16	cells	cell	NNS
cord-005941-e4fvj54l	517	17	Low	low	JJ
cord-005941-e4fvj54l	517	18	yield	yield	NN
cord-005941-e4fvj54l	517	19	of	of	IN
cord-005941-e4fvj54l	517	20	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	517	21	surfactant	surfactant	NN
cord-005941-e4fvj54l	517	22	in	in	IN
cord-005941-e4fvj54l	517	23	cigarette	cigarette	NN
cord-005941-e4fvj54l	517	24	smokers	smoker	NNS
cord-005941-e4fvj54l	517	25	In	in	IN
cord-005941-e4fvj54l	517	26	vivo	vivo	NN
cord-005941-e4fvj54l	517	27	regulation	regulation	NN
cord-005941-e4fvj54l	517	28	of	of	IN
cord-005941-e4fvj54l	517	29	surfactant	surfactant	NN
cord-005941-e4fvj54l	517	30	proteins	protein	NNS
cord-005941-e4fvj54l	517	31	by	by	IN
cord-005941-e4fvj54l	517	32	glucocorticoids	glucocorticoid	NNS
cord-005941-e4fvj54l	517	33	Sixty	Sixty	NNP
cord-005941-e4fvj54l	517	34	years	year	NNS
cord-005941-e4fvj54l	517	35	of	of	IN
cord-005941-e4fvj54l	517	36	surfactant	surfactant	NN
cord-005941-e4fvj54l	517	37	research	research	NN
cord-005941-e4fvj54l	517	38	Isolation	isolation	NN
cord-005941-e4fvj54l	517	39	and	and	CC
cord-005941-e4fvj54l	517	40	characterization	characterization	NN
cord-005941-e4fvj54l	517	41	of	of	IN
cord-005941-e4fvj54l	517	42	cDNA	cdna	NN
cord-005941-e4fvj54l	517	43	clones	clone	NNS
cord-005941-e4fvj54l	517	44	for	for	IN
cord-005941-e4fvj54l	517	45	the	the	DT
cord-005941-e4fvj54l	517	46	35-kDa	35-kda	CD
cord-005941-e4fvj54l	517	47	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	517	48	surfactant	surfactant	NN
cord-005941-e4fvj54l	517	49	-	-	HYPH
cord-005941-e4fvj54l	517	50	associated	associate	VBN
cord-005941-e4fvj54l	517	51	protein	protein	NN
cord-005941-e4fvj54l	517	52	Adult	adult	NN
cord-005941-e4fvj54l	517	53	respiratory	respiratory	JJ
cord-005941-e4fvj54l	517	54	distress	distress	NN
cord-005941-e4fvj54l	517	55	syndrome	syndrome	NN
cord-005941-e4fvj54l	517	56	-prognosis	-prognosis	:
cord-005941-e4fvj54l	517	57	after	after	IN
cord-005941-e4fvj54l	517	58	onset	onset	NN
cord-005941-e4fvj54l	517	59	Artificial	artificial	JJ
cord-005941-e4fvj54l	517	60	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	517	61	surfactant	surfactant	NN
cord-005941-e4fvj54l	517	62	inhibited	inhibit	VBN
cord-005941-e4fvj54l	517	63	by	by	IN
cord-005941-e4fvj54l	517	64	proteins	protein	NNS
cord-005941-e4fvj54l	517	65	Surfactant	Surfactant	NNP
cord-005941-e4fvj54l	517	66	replacement	replacement	NN
cord-005941-e4fvj54l	517	67	therapy	therapy	NN
cord-005941-e4fvj54l	517	68	with	with	IN
cord-005941-e4fvj54l	517	69	a	a	DT
cord-005941-e4fvj54l	517	70	single	single	JJ
cord-005941-e4fvj54l	517	71	postventilatory	postventilatory	JJ
cord-005941-e4fvj54l	517	72	dose	dose	NN
cord-005941-e4fvj54l	517	73	of	of	IN
cord-005941-e4fvj54l	517	74	a	a	DT
cord-005941-e4fvj54l	517	75	reconstituted	reconstitute	VBN
cord-005941-e4fvj54l	517	76	bovine	bovine	JJ
cord-005941-e4fvj54l	517	77	surfactant	surfactant	NN
cord-005941-e4fvj54l	517	78	in	in	IN
cord-005941-e4fvj54l	517	79	preterm	preterm	JJ
cord-005941-e4fvj54l	517	80	neonates	neonate	NNS
cord-005941-e4fvj54l	517	81	with	with	IN
cord-005941-e4fvj54l	517	82	respiratory	respiratory	JJ
cord-005941-e4fvj54l	517	83	distress	distress	NN
cord-005941-e4fvj54l	517	84	syndrome	syndrome	NN
cord-005941-e4fvj54l	517	85	:	:	:
cord-005941-e4fvj54l	517	86	final	final	JJ
cord-005941-e4fvj54l	517	87	analysis	analysis	NN
cord-005941-e4fvj54l	517	88	of	of	IN
cord-005941-e4fvj54l	517	89	a	a	DT
cord-005941-e4fvj54l	517	90	multicenter	multicenter	NN
cord-005941-e4fvj54l	517	91	,	,	,
cord-005941-e4fvj54l	517	92	doubleblind	doubleblind	NN
cord-005941-e4fvj54l	517	93	,	,	,
cord-005941-e4fvj54l	517	94	randomized	randomized	JJ
cord-005941-e4fvj54l	517	95	trial	trial	NN
cord-005941-e4fvj54l	517	96	and	and	CC
cord-005941-e4fvj54l	517	97	comparison	comparison	NN
cord-005941-e4fvj54l	517	98	with	with	IN
cord-005941-e4fvj54l	517	99	similar	similar	JJ
cord-005941-e4fvj54l	517	100	trials	trial	NNS
cord-005941-e4fvj54l	517	101	Lipid	Lipid	NNP
cord-005941-e4fvj54l	517	102	content	content	NN
cord-005941-e4fvj54l	517	103	of	of	IN
cord-005941-e4fvj54l	517	104	alveolar	alveolar	JJ
cord-005941-e4fvj54l	517	105	lining	lining	NN
cord-005941-e4fvj54l	517	106	material	material	NN
cord-005941-e4fvj54l	517	107	collected	collect	VBN
cord-005941-e4fvj54l	517	108	by	by	IN
cord-005941-e4fvj54l	517	109	bronchoalveolar	bronchoalveolar	NNP
cord-005941-e4fvj54l	517	110	lavage	lavage	NNP
cord-005941-e4fvj54l	517	111	Randomized	Randomized	NNP
cord-005941-e4fvj54l	517	112	controlled	control	VBN
cord-005941-e4fvj54l	517	113	trial	trial	NN
cord-005941-e4fvj54l	517	114	of	of	IN
cord-005941-e4fvj54l	517	115	exogenous	exogenous	JJ
cord-005941-e4fvj54l	517	116	surfactant	surfactant	NN
cord-005941-e4fvj54l	517	117	for	for	IN
cord-005941-e4fvj54l	517	118	the	the	DT
cord-005941-e4fvj54l	517	119	treatment	treatment	NN
cord-005941-e4fvj54l	517	120	of	of	IN
cord-005941-e4fvj54l	517	121	hyaline	hyaline	JJ
cord-005941-e4fvj54l	517	122	membrane	membrane	NN
cord-005941-e4fvj54l	517	123	disease	disease	NN
cord-005941-e4fvj54l	517	124	Pharmacological	pharmacological	JJ
cord-005941-e4fvj54l	517	125	treatment	treatment	NN
cord-005941-e4fvj54l	517	126	of	of	IN
cord-005941-e4fvj54l	517	127	the	the	DT
cord-005941-e4fvj54l	517	128	adult	adult	NN
cord-005941-e4fvj54l	517	129	respiratory	respiratory	JJ
cord-005941-e4fvj54l	517	130	distress	distress	NN
cord-005941-e4fvj54l	517	131	syndrome	syndrome	NN
cord-005941-e4fvj54l	518	1	A	a	DT
cord-005941-e4fvj54l	518	2	multicenter	multicenter	NN
cord-005941-e4fvj54l	518	3	randomized	randomize	VBN
cord-005941-e4fvj54l	518	4	controlled	control	VBN
cord-005941-e4fvj54l	518	5	clinical	clinical	JJ
cord-005941-e4fvj54l	518	6	trial	trial	NN
cord-005941-e4fvj54l	518	7	of	of	IN
cord-005941-e4fvj54l	518	8	bovine	bovine	JJ
cord-005941-e4fvj54l	518	9	surfactant	surfactant	NN
cord-005941-e4fvj54l	518	10	for	for	IN
cord-005941-e4fvj54l	518	11	prevention	prevention	NN
cord-005941-e4fvj54l	518	12	of	of	IN
cord-005941-e4fvj54l	518	13	respiratory	respiratory	JJ
cord-005941-e4fvj54l	518	14	distress	distress	NN
cord-005941-e4fvj54l	518	15	syndrome	syndrome	NN
cord-005941-e4fvj54l	518	16	Pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	518	17	defense	defense	NN
cord-005941-e4fvj54l	518	18	mechanisms	mechanism	NNS
cord-005941-e4fvj54l	518	19	in	in	IN
cord-005941-e4fvj54l	518	20	boa	boa	NN
cord-005941-e4fvj54l	518	21	constrictor	constrictor	NN
cord-005941-e4fvj54l	518	22	Effects	effect	NNS
cord-005941-e4fvj54l	518	23	of	of	IN
cord-005941-e4fvj54l	518	24	hydrogen	hydrogen	NN
cord-005941-e4fvj54l	518	25	sulfide	sulfide	NN
cord-005941-e4fvj54l	518	26	exposure	exposure	NN
cord-005941-e4fvj54l	518	27	on	on	IN
cord-005941-e4fvj54l	518	28	surface	surface	NN
cord-005941-e4fvj54l	518	29	properties	property	NNS
cord-005941-e4fvj54l	518	30	of	of	IN
cord-005941-e4fvj54l	518	31	lung	lung	NN
cord-005941-e4fvj54l	518	32	surfactant	surfactant	NN
cord-005941-e4fvj54l	518	33	Increased	increase	VBN
cord-005941-e4fvj54l	518	34	surfactant	surfactant	NN
cord-005941-e4fvj54l	518	35	protein	protein	NN
cord-005941-e4fvj54l	518	36	A	a	NN
cord-005941-e4fvj54l	518	37	(	(	-LRB-
cord-005941-e4fvj54l	518	38	SP	SP	NNP
cord-005941-e4fvj54l	518	39	-	-	HYPH
cord-005941-e4fvj54l	518	40	A	a	NN
cord-005941-e4fvj54l	518	41	)	)	-RRB-
cord-005941-e4fvj54l	518	42	content	content	NN
cord-005941-e4fvj54l	518	43	in	in	IN
cord-005941-e4fvj54l	518	44	human	human	JJ
cord-005941-e4fvj54l	518	45	alveolar	alveolar	NN
cord-005941-e4fvj54l	518	46	macrophages	macrophage	NNS
cord-005941-e4fvj54l	518	47	in	in	IN
cord-005941-e4fvj54l	518	48	hypersensitivity	hypersensitivity	NN
cord-005941-e4fvj54l	518	49	pneumonitis	pneumonitis	NN
cord-005941-e4fvj54l	518	50	Lung	Lung	NNP
cord-005941-e4fvj54l	518	51	surfactant	surfactant	NN
cord-005941-e4fvj54l	518	52	and	and	CC
cord-005941-e4fvj54l	518	53	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	518	54	toxicology	toxicology	NN
cord-005941-e4fvj54l	518	55	Synthesis	Synthesis	NNP
cord-005941-e4fvj54l	518	56	and	and	CC
cord-005941-e4fvj54l	518	57	assembly	assembly	NN
cord-005941-e4fvj54l	518	58	of	of	IN
cord-005941-e4fvj54l	518	59	lung	lung	NN
cord-005941-e4fvj54l	518	60	surfactant	surfactant	NN
cord-005941-e4fvj54l	518	61	Effects	effect	NNS
cord-005941-e4fvj54l	518	62	of	of	IN
cord-005941-e4fvj54l	518	63	ozone	ozone	NN
cord-005941-e4fvj54l	518	64	on	on	IN
cord-005941-e4fvj54l	518	65	phospholipid	phospholipid	NN
cord-005941-e4fvj54l	518	66	synthesis	synthesis	NN
cord-005941-e4fvj54l	518	67	by	by	IN
cord-005941-e4fvj54l	518	68	alveolar	alveolar	JJ
cord-005941-e4fvj54l	518	69	type	type	NN
cord-005941-e4fvj54l	518	70	II	ii	CD
cord-005941-e4fvj54l	518	71	cells	cell	NNS
cord-005941-e4fvj54l	518	72	isolated	isolate	VBN
cord-005941-e4fvj54l	518	73	from	from	IN
cord-005941-e4fvj54l	518	74	adult	adult	NN
cord-005941-e4fvj54l	518	75	rat	rat	NN
cord-005941-e4fvj54l	518	76	lung	lung	NN
cord-005941-e4fvj54l	518	77	Clinical	clinical	JJ
cord-005941-e4fvj54l	518	78	experience	experience	NN
cord-005941-e4fvj54l	518	79	with	with	IN
cord-005941-e4fvj54l	518	80	exogenous	exogenous	JJ
cord-005941-e4fvj54l	518	81	natural	natural	JJ
cord-005941-e4fvj54l	518	82	surfactant	surfactant	NN
cord-005941-e4fvj54l	518	83	Absence	absence	NN
cord-005941-e4fvj54l	518	84	of	of	IN
cord-005941-e4fvj54l	518	85	phosphatidylglycerol	phosphatidylglycerol	JJ
cord-005941-e4fvj54l	518	86	(	(	-LRB-
cord-005941-e4fvj54l	518	87	PG	PG	NNP
cord-005941-e4fvj54l	518	88	)	)	-RRB-
cord-005941-e4fvj54l	518	89	in	in	IN
cord-005941-e4fvj54l	518	90	respiratory	respiratory	JJ
cord-005941-e4fvj54l	518	91	distress	distress	NN
cord-005941-e4fvj54l	518	92	syndrome	syndrome	NN
cord-005941-e4fvj54l	518	93	in	in	IN
cord-005941-e4fvj54l	518	94	the	the	DT
cord-005941-e4fvj54l	518	95	newborn	newborn	JJ
cord-005941-e4fvj54l	518	96	Analysis	Analysis	NNP
cord-005941-e4fvj54l	518	97	of	of	IN
cord-005941-e4fvj54l	518	98	labeling	labeling	NN
cord-005941-e4fvj54l	518	99	and	and	CC
cord-005941-e4fvj54l	518	100	clearance	clearance	NN
cord-005941-e4fvj54l	518	101	of	of	IN
cord-005941-e4fvj54l	518	102	lung	lung	NN
cord-005941-e4fvj54l	518	103	surfactant	surfactant	NN
cord-005941-e4fvj54l	518	104	phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	518	105	in	in	IN
cord-005941-e4fvj54l	518	106	rabbit	rabbit	NN
cord-005941-e4fvj54l	518	107	Evidence	evidence	NN
cord-005941-e4fvj54l	518	108	of	of	IN
cord-005941-e4fvj54l	518	109	lung	lung	NN
cord-005941-e4fvj54l	518	110	surfactant	surfactant	NN
cord-005941-e4fvj54l	518	111	abnormality	abnormality	NN
cord-005941-e4fvj54l	518	112	in	in	IN
cord-005941-e4fvj54l	518	113	respiratory	respiratory	JJ
cord-005941-e4fvj54l	518	114	failure	failure	NN
cord-005941-e4fvj54l	518	115	Changes	change	NNS
cord-005941-e4fvj54l	518	116	in	in	IN
cord-005941-e4fvj54l	518	117	surfactant	surfactant	NN
cord-005941-e4fvj54l	518	118	in	in	IN
cord-005941-e4fvj54l	518	119	bronchoalveolar	bronchoalveolar	NNP
cord-005941-e4fvj54l	518	120	lavage	lavage	NN
cord-005941-e4fvj54l	518	121	fluid	fluid	NN
cord-005941-e4fvj54l	518	122	after	after	IN
cord-005941-e4fvj54l	518	123	hemithorax	hemithorax	NN
cord-005941-e4fvj54l	518	124	irradiation	irradiation	NN
cord-005941-e4fvj54l	518	125	in	in	IN
cord-005941-e4fvj54l	518	126	patients	patient	NNS
cord-005941-e4fvj54l	518	127	with	with	IN
cord-005941-e4fvj54l	518	128	mesothelioma	mesothelioma	NN
cord-005941-e4fvj54l	518	129	Surfactant	Surfactant	NNP
cord-005941-e4fvj54l	518	130	protein	protein	NN
cord-005941-e4fvj54l	518	131	A	a	NN
cord-005941-e4fvj54l	518	132	in	in	IN
cord-005941-e4fvj54l	518	133	bronchoalveolar	bronchoalveolar	JJ
cord-005941-e4fvj54l	518	134	lavage	lavage	NN
cord-005941-e4fvj54l	518	135	of	of	IN
cord-005941-e4fvj54l	518	136	sarcoidosis	sarcoidosis	NN
cord-005941-e4fvj54l	518	137	and	and	CC
cord-005941-e4fvj54l	518	138	hypersensitivity	hypersensitivity	NN
cord-005941-e4fvj54l	518	139	pneumonitis	pneumonitis	NN
cord-005941-e4fvj54l	518	140	Phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	518	141	as	as	IN
cord-005941-e4fvj54l	518	142	dynamic	dynamic	JJ
cord-005941-e4fvj54l	518	143	participants	participant	NNS
cord-005941-e4fvj54l	518	144	in	in	IN
cord-005941-e4fvj54l	518	145	biological	biological	JJ
cord-005941-e4fvj54l	518	146	processes	process	NNS
cord-005941-e4fvj54l	518	147	Lung	Lung	NNP
cord-005941-e4fvj54l	518	148	surfactant	surfactant	NN
cord-005941-e4fvj54l	518	149	Surfactant	surfactant	NN
cord-005941-e4fvj54l	518	150	cholesterol	cholesterol	NN
cord-005941-e4fvj54l	518	151	metabolism	metabolism	NN
cord-005941-e4fvj54l	518	152	of	of	IN
cord-005941-e4fvj54l	518	153	the	the	DT
cord-005941-e4fvj54l	518	154	isolated	isolate	VBN
cord-005941-e4fvj54l	518	155	perfused	perfuse	VBN
cord-005941-e4fvj54l	518	156	rat	rat	NN
cord-005941-e4fvj54l	518	157	lung	lung	NN
cord-005941-e4fvj54l	518	158	Pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	518	159	surfactant	surfactant	NN
cord-005941-e4fvj54l	518	160	apoproteins	apoprotein	NNS
cord-005941-e4fvj54l	518	161	:	:	:
cord-005941-e4fvj54l	518	162	a	a	DT
cord-005941-e4fvj54l	518	163	review	review	NN
cord-005941-e4fvj54l	518	164	of	of	IN
cord-005941-e4fvj54l	518	165	protein	protein	NN
cord-005941-e4fvj54l	518	166	and	and	CC
cord-005941-e4fvj54l	518	167	genomic	genomic	JJ
cord-005941-e4fvj54l	518	168	structure	structure	NN
cord-005941-e4fvj54l	518	169	Lung	Lung	NNP
cord-005941-e4fvj54l	518	170	lipids	lipid	NNS
cord-005941-e4fvj54l	518	171	and	and	CC
cord-005941-e4fvj54l	518	172	disease	disease	NN
cord-005941-e4fvj54l	518	173	.	.	.
cord-005941-e4fvj54l	519	1	Respiration	respiration	NN
cord-005941-e4fvj54l	519	2	55	55	CD
cord-005941-e4fvj54l	519	3	Pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	519	4	surface	surface	NN
cord-005941-e4fvj54l	519	5	film	film	NN
cord-005941-e4fvj54l	519	6	stability	stability	NN
cord-005941-e4fvj54l	519	7	and	and	CC
cord-005941-e4fvj54l	519	8	composition	composition	NN
cord-005941-e4fvj54l	520	1	The	the	DT
cord-005941-e4fvj54l	520	2	role	role	NN
cord-005941-e4fvj54l	520	3	of	of	IN
cord-005941-e4fvj54l	520	4	lung	lung	NN
cord-005941-e4fvj54l	520	5	surfactant	surfactant	NN
cord-005941-e4fvj54l	520	6	Role	role	NN
cord-005941-e4fvj54l	520	7	of	of	IN
cord-005941-e4fvj54l	520	8	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	520	9	surfactant	surfactant	NN
cord-005941-e4fvj54l	520	10	in	in	IN
cord-005941-e4fvj54l	520	11	the	the	DT
cord-005941-e4fvj54l	520	12	development	development	NN
cord-005941-e4fvj54l	520	13	and	and	CC
cord-005941-e4fvj54l	520	14	treatment	treatment	NN
cord-005941-e4fvj54l	520	15	of	of	IN
cord-005941-e4fvj54l	520	16	adult	adult	NN
cord-005941-e4fvj54l	520	17	respiratory	respiratory	JJ
cord-005941-e4fvj54l	520	18	distress	distress	NN
cord-005941-e4fvj54l	520	19	syndrome	syndrome	NN
cord-005941-e4fvj54l	520	20	Effects	effect	NNS
cord-005941-e4fvj54l	520	21	of	of	IN
cord-005941-e4fvj54l	520	22	hemoglobin	hemoglobin	NN
cord-005941-e4fvj54l	520	23	and	and	CC
cord-005941-e4fvj54l	520	24	cell	cell	NN
cord-005941-e4fvj54l	520	25	membrane	membrane	NN
cord-005941-e4fvj54l	520	26	lipids	lipid	NNS
cord-005941-e4fvj54l	520	27	on	on	IN
cord-005941-e4fvj54l	520	28	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	520	29	surfactant	surfactant	NN
cord-005941-e4fvj54l	520	30	activity	activity	NN
cord-005941-e4fvj54l	520	31	Surface	surface	NN
cord-005941-e4fvj54l	520	32	property	property	NN
cord-005941-e4fvj54l	520	33	changes	change	NNS
cord-005941-e4fvj54l	520	34	from	from	IN
cord-005941-e4fvj54l	520	35	interactions	interaction	NNS
cord-005941-e4fvj54l	520	36	of	of	IN
cord-005941-e4fvj54l	520	37	albumin	albumin	NN
cord-005941-e4fvj54l	520	38	with	with	IN
cord-005941-e4fvj54l	520	39	natural	natural	JJ
cord-005941-e4fvj54l	520	40	surfactant	surfactant	NN
cord-005941-e4fvj54l	520	41	and	and	CC
cord-005941-e4fvj54l	520	42	extracted	extract	VBN
cord-005941-e4fvj54l	520	43	lung	lung	NN
cord-005941-e4fvj54l	520	44	lipids	lipid	NNS
cord-005941-e4fvj54l	520	45	Type	Type	NNP
cord-005941-e4fvj54l	520	46	II	II	NNP
cord-005941-e4fvj54l	520	47	pneumocyte	pneumocyte	NN
cord-005941-e4fvj54l	520	48	changes	change	VBZ
cord-005941-e4fvj54l	520	49	during	during	IN
cord-005941-e4fvj54l	520	50	hyperoxic	hyperoxic	NNP
cord-005941-e4fvj54l	520	51	lung	lung	NNP
cord-005941-e4fvj54l	520	52	injury	injury	NN
cord-005941-e4fvj54l	520	53	and	and	CC
cord-005941-e4fvj54l	520	54	recovery	recovery	NN
cord-005941-e4fvj54l	520	55	Down	down	IN
cord-005941-e4fvj54l	520	56	-	-	HYPH
cord-005941-e4fvj54l	520	57	regulation	regulation	NN
cord-005941-e4fvj54l	520	58	of	of	IN
cord-005941-e4fvj54l	520	59	immune	immune	JJ
cord-005941-e4fvj54l	520	60	responses	response	NNS
cord-005941-e4fvj54l	520	61	in	in	IN
cord-005941-e4fvj54l	520	62	the	the	DT
cord-005941-e4fvj54l	520	63	lower	low	JJR
cord-005941-e4fvj54l	520	64	respiratory	respiratory	JJ
cord-005941-e4fvj54l	520	65	tract	tract	NN
cord-005941-e4fvj54l	520	66	:	:	:
cord-005941-e4fvj54l	520	67	the	the	DT
cord-005941-e4fvj54l	520	68	role	role	NN
cord-005941-e4fvj54l	520	69	of	of	IN
cord-005941-e4fvj54l	520	70	alveolar	alveolar	JJ
cord-005941-e4fvj54l	520	71	macrophages	macrophage	NNS
cord-005941-e4fvj54l	520	72	Changes	change	NNS
cord-005941-e4fvj54l	520	73	in	in	IN
cord-005941-e4fvj54l	520	74	phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	520	75	in	in	IN
cord-005941-e4fvj54l	520	76	bronchoalveolar	bronchoalveolar	NNP
cord-005941-e4fvj54l	520	77	lavage	lavage	NN
cord-005941-e4fvj54l	520	78	fluid	fluid	NN
cord-005941-e4fvj54l	520	79	of	of	IN
cord-005941-e4fvj54l	520	80	patients	patient	NNS
cord-005941-e4fvj54l	520	81	with	with	IN
cord-005941-e4fvj54l	520	82	interstitial	interstitial	JJ
cord-005941-e4fvj54l	520	83	lung	lung	NN
cord-005941-e4fvj54l	520	84	diseases	disease	NNS
cord-005941-e4fvj54l	520	85	Alterations	alteration	NNS
cord-005941-e4fvj54l	520	86	of	of	IN
cord-005941-e4fvj54l	520	87	acidic	acidic	JJ
cord-005941-e4fvj54l	520	88	phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	520	89	in	in	IN
cord-005941-e4fvj54l	520	90	bronchoalveolar	bronchoalveolar	JJ
cord-005941-e4fvj54l	520	91	lavage	lavage	NN
cord-005941-e4fvj54l	520	92	fluids	fluid	NNS
cord-005941-e4fvj54l	520	93	of	of	IN
cord-005941-e4fvj54l	520	94	patients	patient	NNS
cord-005941-e4fvj54l	520	95	with	with	IN
cord-005941-e4fvj54l	520	96	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	520	97	alveolar	alveolar	NN
cord-005941-e4fvj54l	520	98	proteinosis	proteinosis	NN
cord-005941-e4fvj54l	520	99	Dissolution	Dissolution	NNP
cord-005941-e4fvj54l	520	100	and	and	CC
cord-005941-e4fvj54l	520	101	reassembly	reassembly	NN
cord-005941-e4fvj54l	520	102	of	of	IN
cord-005941-e4fvj54l	520	103	tubular	tubular	JJ
cord-005941-e4fvj54l	520	104	myelin	myelin	NN
cord-005941-e4fvj54l	520	105	-	-	HYPH
cord-005941-e4fvj54l	520	106	like	like	JJ
cord-005941-e4fvj54l	520	107	multilamellated	multilamellated	JJ
cord-005941-e4fvj54l	520	108	structures	structure	NNS
cord-005941-e4fvj54l	520	109	from	from	IN
cord-005941-e4fvj54l	520	110	the	the	DT
cord-005941-e4fvj54l	520	111	lungs	lung	NNS
cord-005941-e4fvj54l	520	112	of	of	IN
cord-005941-e4fvj54l	520	113	patients	patient	NNS
cord-005941-e4fvj54l	520	114	with	with	IN
cord-005941-e4fvj54l	520	115	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	520	116	alveolar	alveolar	NN
cord-005941-e4fvj54l	520	117	proteinosis	proteinosis	NN
cord-005941-e4fvj54l	520	118	A	A	NNP
cord-005941-e4fvj54l	520	119	multicenter	multicenter	NN
cord-005941-e4fvj54l	520	120	,	,	,
cord-005941-e4fvj54l	520	121	randomized	randomized	JJ
cord-005941-e4fvj54l	520	122	,	,	,
cord-005941-e4fvj54l	520	123	placebo	placebo	NN
cord-005941-e4fvj54l	520	124	-	-	HYPH
cord-005941-e4fvj54l	520	125	controlled	control	VBN
cord-005941-e4fvj54l	520	126	trial	trial	NN
cord-005941-e4fvj54l	520	127	of	of	IN
cord-005941-e4fvj54l	520	128	surfactant	surfactant	NN
cord-005941-e4fvj54l	520	129	therapy	therapy	NN
cord-005941-e4fvj54l	520	130	for	for	IN
cord-005941-e4fvj54l	520	131	respiratory	respiratory	JJ
cord-005941-e4fvj54l	520	132	distress	distress	NN
cord-005941-e4fvj54l	520	133	syndrome	syndrome	NN
cord-005941-e4fvj54l	520	134	Surface	surface	NN
cord-005941-e4fvj54l	520	135	and	and	CC
cord-005941-e4fvj54l	520	136	tissue	tissue	NN
cord-005941-e4fvj54l	520	137	forces	force	NNS
cord-005941-e4fvj54l	520	138	,	,	,
cord-005941-e4fvj54l	520	139	surfactant	surfactant	NN
cord-005941-e4fvj54l	520	140	protein	protein	NN
cord-005941-e4fvj54l	520	141	A	A	NNP
cord-005941-e4fvj54l	520	142	,	,	,
cord-005941-e4fvj54l	520	143	and	and	CC
cord-005941-e4fvj54l	520	144	the	the	DT
cord-005941-e4fvj54l	520	145	phospholipid	phospholipid	NN
cord-005941-e4fvj54l	520	146	components	component	NNS
cord-005941-e4fvj54l	520	147	of	of	IN
cord-005941-e4fvj54l	520	148	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	520	149	surfactant	surfactant	NN
cord-005941-e4fvj54l	520	150	in	in	IN
cord-005941-e4fvj54l	520	151	bleomycin	bleomycin	NN
cord-005941-e4fvj54l	520	152	-	-	HYPH
cord-005941-e4fvj54l	520	153	induced	induce	VBN
cord-005941-e4fvj54l	520	154	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	520	155	fibrosis	fibrosis	NN
cord-005941-e4fvj54l	520	156	in	in	IN
cord-005941-e4fvj54l	520	157	the	the	DT
cord-005941-e4fvj54l	520	158	rat	rat	NN
cord-005941-e4fvj54l	520	159	Changes	change	NNS
cord-005941-e4fvj54l	520	160	in	in	IN
cord-005941-e4fvj54l	520	161	phosphatidylglycerol	phosphatidylglycerol	NNP
cord-005941-e4fvj54l	520	162	in	in	IN
cord-005941-e4fvj54l	520	163	bronchoalveolar	bronchoalveolar	NNP
cord-005941-e4fvj54l	520	164	lavage	lavage	NN
cord-005941-e4fvj54l	520	165	fluids	fluid	NNS
cord-005941-e4fvj54l	520	166	from	from	IN
cord-005941-e4fvj54l	520	167	patients	patient	NNS
cord-005941-e4fvj54l	520	168	with	with	IN
cord-005941-e4fvj54l	520	169	cryptogenic	cryptogenic	NNP
cord-005941-e4fvj54l	520	170	fibrosing	fibrose	VBG
cord-005941-e4fvj54l	520	171	alveolitis	alveolitis	NNP
cord-005941-e4fvj54l	520	172	Changes	change	NNS
cord-005941-e4fvj54l	520	173	of	of	IN
cord-005941-e4fvj54l	520	174	alveolar	alveolar	JJ
cord-005941-e4fvj54l	520	175	stability	stability	NN
cord-005941-e4fvj54l	520	176	and	and	CC
cord-005941-e4fvj54l	520	177	phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	520	178	in	in	IN
cord-005941-e4fvj54l	520	179	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	520	180	surfactant	surfactant	NN
cord-005941-e4fvj54l	520	181	in	in	IN
cord-005941-e4fvj54l	520	182	acute	acute	JJ
cord-005941-e4fvj54l	520	183	pancreatitis	pancreatitis	NN
cord-005941-e4fvj54l	520	184	Surfactant	Surfactant	NNP
cord-005941-e4fvj54l	520	185	for	for	IN
cord-005941-e4fvj54l	520	186	the	the	DT
cord-005941-e4fvj54l	520	187	treatment	treatment	NN
cord-005941-e4fvj54l	520	188	of	of	IN
cord-005941-e4fvj54l	520	189	respiratory	respiratory	JJ
cord-005941-e4fvj54l	520	190	distress	distress	NN
cord-005941-e4fvj54l	520	191	syndrome	syndrome	NN
cord-005941-e4fvj54l	520	192	Surfactant	Surfactant	NNP
cord-005941-e4fvj54l	520	193	protein	protein	NN
cord-005941-e4fvj54l	520	194	B	b	NN
cord-005941-e4fvj54l	520	195	:	:	:
cord-005941-e4fvj54l	520	196	disulfide	disulfide	NN
cord-005941-e4fvj54l	520	197	bridges	bridge	NNS
cord-005941-e4fvj54l	520	198	,	,	,
cord-005941-e4fvj54l	520	199	structural	structural	JJ
cord-005941-e4fvj54l	520	200	properties	property	NNS
cord-005941-e4fvj54l	520	201	,	,	,
cord-005941-e4fvj54l	520	202	and	and	CC
cord-005941-e4fvj54l	520	203	kringle	kringle	NNP
cord-005941-e4fvj54l	520	204	similarities	similarity	NNS
cord-005941-e4fvj54l	520	205	Human	Human	NNP
cord-005941-e4fvj54l	520	206	alveolar	alveolar	NN
cord-005941-e4fvj54l	520	207	lining	lining	NN
cord-005941-e4fvj54l	520	208	material	material	NN
cord-005941-e4fvj54l	520	209	and	and	CC
cord-005941-e4fvj54l	520	210	antibacterial	antibacterial	JJ
cord-005941-e4fvj54l	521	1	defenses	defense	NNS
cord-005941-e4fvj54l	521	2	Types	type	NNS
cord-005941-e4fvj54l	521	3	of	of	IN
cord-005941-e4fvj54l	521	4	interaction	interaction	NN
cord-005941-e4fvj54l	521	5	of	of	IN
cord-005941-e4fvj54l	521	6	amphiphilic	amphiphilic	JJ
cord-005941-e4fvj54l	521	7	drugs	drug	NNS
cord-005941-e4fvj54l	521	8	with	with	IN
cord-005941-e4fvj54l	521	9	phospholipid	phospholipid	NN
cord-005941-e4fvj54l	521	10	vesicles	vesicle	NNS
cord-005941-e4fvj54l	521	11	Enhancement	Enhancement	NNP
cord-005941-e4fvj54l	521	12	of	of	IN
cord-005941-e4fvj54l	521	13	bactericidal	bactericidal	JJ
cord-005941-e4fvj54l	521	14	capacity	capacity	NN
cord-005941-e4fvj54l	521	15	of	of	IN
cord-005941-e4fvj54l	521	16	alveolar	alveolar	JJ
cord-005941-e4fvj54l	521	17	macrophages	macrophage	NNS
cord-005941-e4fvj54l	521	18	by	by	IN
cord-005941-e4fvj54l	521	19	human	human	JJ
cord-005941-e4fvj54l	521	20	alveolar	alveolar	NN
cord-005941-e4fvj54l	521	21	lining	lining	NN
cord-005941-e4fvj54l	521	22	material	material	NN
cord-005941-e4fvj54l	521	23	Analysis	Analysis	NNP
cord-005941-e4fvj54l	521	24	of	of	IN
cord-005941-e4fvj54l	521	25	bronchoalveolar	bronchoalveolar	NNP
cord-005941-e4fvj54l	521	26	lavage	lavage	NN
cord-005941-e4fvj54l	521	27	and	and	CC
cord-005941-e4fvj54l	521	28	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	521	29	alveolar	alveolar	NN
cord-005941-e4fvj54l	521	30	surfactant	surfactant	NN
cord-005941-e4fvj54l	521	31	for	for	IN
cord-005941-e4fvj54l	521	32	diagnosis	diagnosis	NN
cord-005941-e4fvj54l	521	33	of	of	IN
cord-005941-e4fvj54l	521	34	rejection	rejection	NN
cord-005941-e4fvj54l	521	35	and	and	CC
cord-005941-e4fvj54l	521	36	infection	infection	NN
cord-005941-e4fvj54l	521	37	in	in	IN
cord-005941-e4fvj54l	521	38	heart	heart	NN
cord-005941-e4fvj54l	521	39	-	-	HYPH
cord-005941-e4fvj54l	521	40	lung	lung	NN
cord-005941-e4fvj54l	521	41	transplantation	transplantation	NN
cord-005941-e4fvj54l	521	42	Alveolar	Alveolar	NNP
cord-005941-e4fvj54l	521	43	type	type	NN
cord-005941-e4fvj54l	521	44	II	ii	CD
cord-005941-e4fvj54l	521	45	cells	cell	NNS
cord-005941-e4fvj54l	521	46	,	,	,
cord-005941-e4fvj54l	521	47	surfactant	surfactant	NN
cord-005941-e4fvj54l	521	48	protein	protein	NN
cord-005941-e4fvj54l	521	49	A	a	NN
cord-005941-e4fvj54l	521	50	(	(	-LRB-
cord-005941-e4fvj54l	521	51	SP	SP	NNP
cord-005941-e4fvj54l	521	52	-	-	HYPH
cord-005941-e4fvj54l	521	53	A	A	NNP
cord-005941-e4fvj54l	521	54	)	)	-RRB-
cord-005941-e4fvj54l	521	55	,	,	,
cord-005941-e4fvj54l	521	56	and	and	CC
cord-005941-e4fvj54l	521	57	the	the	DT
cord-005941-e4fvj54l	521	58	phospholipid	phospholipid	NN
cord-005941-e4fvj54l	521	59	components	component	NNS
cord-005941-e4fvj54l	521	60	of	of	IN
cord-005941-e4fvj54l	521	61	surfactant	surfactant	NN
cord-005941-e4fvj54l	521	62	in	in	IN
cord-005941-e4fvj54l	521	63	acute	acute	JJ
cord-005941-e4fvj54l	521	64	silicosis	silicosis	NN
cord-005941-e4fvj54l	521	65	in	in	IN
cord-005941-e4fvj54l	521	66	the	the	DT
cord-005941-e4fvj54l	521	67	rat	rat	NN
cord-005941-e4fvj54l	521	68	Structure	Structure	NNP
cord-005941-e4fvj54l	521	69	of	of	IN
cord-005941-e4fvj54l	521	70	alveolar	alveolar	JJ
cord-005941-e4fvj54l	521	71	epithelial	epithelial	JJ
cord-005941-e4fvj54l	521	72	cells	cell	NNS
cord-005941-e4fvj54l	521	73	in	in	IN
cord-005941-e4fvj54l	521	74	patients	patient	NNS
cord-005941-e4fvj54l	521	75	with	with	IN
cord-005941-e4fvj54l	521	76	fibrotic	fibrotic	JJ
cord-005941-e4fvj54l	521	77	lung	lung	NN
cord-005941-e4fvj54l	521	78	disorders	disorder	NNS
cord-005941-e4fvj54l	521	79	Fluid	Fluid	NNP
cord-005941-e4fvj54l	521	80	dynamics	dynamic	NNS
cord-005941-e4fvj54l	521	81	during	during	IN
cord-005941-e4fvj54l	521	82	bronchoalveolar	bronchoalveolar	NNP
cord-005941-e4fvj54l	521	83	lavage	lavage	NN
cord-005941-e4fvj54l	521	84	Secretions	secretion	NNS
cord-005941-e4fvj54l	521	85	from	from	IN
cord-005941-e4fvj54l	521	86	primary	primary	JJ
cord-005941-e4fvj54l	521	87	hamster	hamster	NN
cord-005941-e4fvj54l	521	88	tracheal	tracheal	NN
cord-005941-e4fvj54l	521	89	surface	surface	NN
cord-005941-e4fvj54l	521	90	epithelial	epithelial	JJ
cord-005941-e4fvj54l	521	91	cells	cell	NNS
cord-005941-e4fvj54l	521	92	in	in	IN
cord-005941-e4fvj54l	521	93	culture	culture	NN
cord-005941-e4fvj54l	521	94	:	:	:
cord-005941-e4fvj54l	521	95	mucin	mucin	NN
cord-005941-e4fvj54l	521	96	-	-	HYPH
cord-005941-e4fvj54l	521	97	like	like	JJ
cord-005941-e4fvj54l	521	98	glycoproteins	glycoprotein	NNS
cord-005941-e4fvj54l	521	99	,	,	,
cord-005941-e4fvj54l	521	100	proteoglycans	proteoglycan	NNS
cord-005941-e4fvj54l	521	101	,	,	,
cord-005941-e4fvj54l	521	102	and	and	CC
cord-005941-e4fvj54l	521	103	lipids	lipid	NNS
cord-005941-e4fvj54l	521	104	Isolation	isolation	NN
cord-005941-e4fvj54l	521	105	of	of	IN
cord-005941-e4fvj54l	521	106	apoproteins	apoprotein	NNS
cord-005941-e4fvj54l	521	107	from	from	IN
cord-005941-e4fvj54l	521	108	canine	canine	JJ
cord-005941-e4fvj54l	521	109	surface	surface	NN
cord-005941-e4fvj54l	521	110	active	active	JJ
cord-005941-e4fvj54l	521	111	material	material	NN
cord-005941-e4fvj54l	522	1	-and	-and	:
cord-005941-e4fvj54l	522	2	pneumonia	pneumonia	NN
cord-005941-e4fvj54l	522	3	-	-	HYPH
cord-005941-e4fvj54l	522	4	induced	induce	VBN
cord-005941-e4fvj54l	522	5	lung	lung	NN
cord-005941-e4fvj54l	522	6	injury	injury	NN
cord-005941-e4fvj54l	522	7	.	.	.
cord-005941-e4fvj54l	523	1	II	II	NNP
cord-005941-e4fvj54l	523	2	.	.	.
cord-005941-e4fvj54l	524	1	Properties	property	NNS
cord-005941-e4fvj54l	524	2	of	of	IN
cord-005941-e4fvj54l	524	3	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	524	4	surfactant	surfactant	NN
cord-005941-e4fvj54l	524	5	Pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	524	6	surfactant	surfactant	NN
cord-005941-e4fvj54l	524	7	in	in	IN
cord-005941-e4fvj54l	524	8	bronchoalveolar	bronchoalveolar	NNP
cord-005941-e4fvj54l	524	9	lavage	lavage	NN
cord-005941-e4fvj54l	524	10	after	after	IN
cord-005941-e4fvj54l	524	11	canine	canine	JJ
cord-005941-e4fvj54l	524	12	lung	lung	NN
cord-005941-e4fvj54l	524	13	transplantation	transplantation	NN
cord-005941-e4fvj54l	524	14	Inactivation	Inactivation	NNP
cord-005941-e4fvj54l	524	15	of	of	IN
cord-005941-e4fvj54l	524	16	exogenous	exogenous	JJ
cord-005941-e4fvj54l	524	17	surfactant	surfactant	NN
cord-005941-e4fvj54l	524	18	by	by	IN
cord-005941-e4fvj54l	524	19	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	524	20	edema	edema	NN
cord-005941-e4fvj54l	524	21	fluid	fluid	NN
cord-005941-e4fvj54l	524	22	Surfactant	Surfactant	NNP
cord-005941-e4fvj54l	524	23	protein	protein	NN
cord-005941-e4fvj54l	524	24	D	d	NN
cord-005941-e4fvj54l	524	25	(	(	-LRB-
cord-005941-e4fvj54l	524	26	SP	SP	NNP
cord-005941-e4fvj54l	524	27	-	-	HYPH
cord-005941-e4fvj54l	524	28	D	D	NNP
cord-005941-e4fvj54l	524	29	)	)	-RRB-
cord-005941-e4fvj54l	524	30	counteracts	counteract	VBZ
cord-005941-e4fvj54l	524	31	the	the	DT
cord-005941-e4fvj54l	524	32	inhibitory	inhibitory	JJ
cord-005941-e4fvj54l	524	33	effect	effect	NN
cord-005941-e4fvj54l	524	34	of	of	IN
cord-005941-e4fvj54l	524	35	surfactant	surfactant	NN
cord-005941-e4fvj54l	524	36	protein	protein	NN
cord-005941-e4fvj54l	524	37	A	a	NN
cord-005941-e4fvj54l	524	38	(	(	-LRB-
cord-005941-e4fvj54l	524	39	SP	SP	NNP
cord-005941-e4fvj54l	524	40	-	-	HYPH
cord-005941-e4fvj54l	524	41	A	A	NNP
cord-005941-e4fvj54l	524	42	)	)	-RRB-
cord-005941-e4fvj54l	524	43	on	on	IN
cord-005941-e4fvj54l	524	44	phospholipid	phospholipid	NN
cord-005941-e4fvj54l	524	45	secretion	secretion	NN
cord-005941-e4fvj54l	524	46	by	by	IN
cord-005941-e4fvj54l	524	47	alveolar	alveolar	NN
cord-005941-e4fvj54l	524	48	type	type	NN
cord-005941-e4fvj54l	524	49	II	ii	CD
cord-005941-e4fvj54l	524	50	cells	cell	NNS
cord-005941-e4fvj54l	524	51	Characterization	characterization	NN
cord-005941-e4fvj54l	524	52	of	of	IN
cord-005941-e4fvj54l	524	53	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	524	54	surfactant	surfactant	NN
cord-005941-e4fvj54l	524	55	protein	protein	NN
cord-005941-e4fvj54l	524	56	D	D	NNP
cord-005941-e4fvj54l	524	57	:	:	:
cord-005941-e4fvj54l	524	58	its	-PRON-	PRP$
cord-005941-e4fvj54l	524	59	copurification	copurification	NN
cord-005941-e4fvj54l	524	60	with	with	IN
cord-005941-e4fvj54l	524	61	lipids	lipid	NNS
cord-005941-e4fvj54l	524	62	Animal	Animal	NNP
cord-005941-e4fvj54l	524	63	models	model	NNS
cord-005941-e4fvj54l	524	64	and	and	CC
cord-005941-e4fvj54l	524	65	clinical	clinical	JJ
cord-005941-e4fvj54l	524	66	pilot	pilot	NN
cord-005941-e4fvj54l	524	67	studies	study	NNS
cord-005941-e4fvj54l	524	68	of	of	IN
cord-005941-e4fvj54l	524	69	surfactant	surfactant	NN
cord-005941-e4fvj54l	524	70	replacement	replacement	NN
cord-005941-e4fvj54l	524	71	in	in	IN
cord-005941-e4fvj54l	524	72	adult	adult	JJ
cord-005941-e4fvj54l	524	73	respiratory	respiratory	JJ
cord-005941-e4fvj54l	524	74	distress	distress	NN
cord-005941-e4fvj54l	524	75	syndrome	syndrome	NN
cord-005941-e4fvj54l	524	76	Surfactant	Surfactant	NNP
cord-005941-e4fvj54l	524	77	replacement	replacement	NN
cord-005941-e4fvj54l	524	78	improves	improve	VBZ
cord-005941-e4fvj54l	524	79	lung	lung	NN
cord-005941-e4fvj54l	524	80	recoil	recoil	NN
cord-005941-e4fvj54l	524	81	in	in	IN
cord-005941-e4fvj54l	524	82	rabbit	rabbit	NN
cord-005941-e4fvj54l	524	83	lungs	lung	NNS
cord-005941-e4fvj54l	524	84	after	after	IN
cord-005941-e4fvj54l	524	85	acid	acid	NN
cord-005941-e4fvj54l	524	86	aspiration	aspiration	NN
cord-005941-e4fvj54l	524	87	Injury	injury	NN
cord-005941-e4fvj54l	524	88	to	to	TO
cord-005941-e4fvj54l	524	89	type	type	VB
cord-005941-e4fvj54l	524	90	II	II	NNP
cord-005941-e4fvj54l	524	91	pneumocytes	pneumocyte	NNS
cord-005941-e4fvj54l	524	92	in	in	IN
cord-005941-e4fvj54l	524	93	rats	rat	NNS
cord-005941-e4fvj54l	524	94	exposed	expose	VBN
cord-005941-e4fvj54l	524	95	to	to	IN
cord-005941-e4fvj54l	525	1	cigarette	cigarette	NN
cord-005941-e4fvj54l	525	2	smoke	smoke	NN
cord-005941-e4fvj54l	525	3	Endotoxin	Endotoxin	NNP
cord-005941-e4fvj54l	525	4	suppresses	suppress	VBZ
cord-005941-e4fvj54l	525	5	surfactant	surfactant	NN
cord-005941-e4fvj54l	525	6	synthesis	synthesis	NN
cord-005941-e4fvj54l	525	7	in	in	IN
cord-005941-e4fvj54l	525	8	cultured	cultured	JJ
cord-005941-e4fvj54l	525	9	rat	rat	NN
cord-005941-e4fvj54l	525	10	lung	lung	NN
cord-005941-e4fvj54l	525	11	cells	cell	VBZ
cord-005941-e4fvj54l	525	12	Functional	functional	JJ
cord-005941-e4fvj54l	525	13	abnormalities	abnormality	NNS
cord-005941-e4fvj54l	525	14	of	of	IN
cord-005941-e4fvj54l	525	15	lung	lung	NN
cord-005941-e4fvj54l	525	16	surfactant	surfactant	NN
cord-005941-e4fvj54l	525	17	in	in	IN
cord-005941-e4fvj54l	525	18	experimental	experimental	JJ
cord-005941-e4fvj54l	525	19	acute	acute	JJ
cord-005941-e4fvj54l	525	20	alveolar	alveolar	JJ
cord-005941-e4fvj54l	525	21	injury	injury	NN
cord-005941-e4fvj54l	525	22	in	in	IN
cord-005941-e4fvj54l	525	23	the	the	DT
cord-005941-e4fvj54l	525	24	dog	dog	NN
cord-005941-e4fvj54l	526	1	Glucocorticoids	Glucocorticoids	NNP
cord-005941-e4fvj54l	526	2	both	both	DT
cord-005941-e4fvj54l	526	3	stimulate	stimulate	VBP
cord-005941-e4fvj54l	526	4	and	and	CC
cord-005941-e4fvj54l	526	5	inhibit	inhibit	VBP
cord-005941-e4fvj54l	526	6	production	production	NN
cord-005941-e4fvj54l	526	7	of	of	IN
cord-005941-e4fvj54l	526	8	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	526	9	surfactant	surfactant	NN
cord-005941-e4fvj54l	526	10	protein	protein	NN
cord-005941-e4fvj54l	526	11	A	a	NN
cord-005941-e4fvj54l	526	12	in	in	IN
cord-005941-e4fvj54l	526	13	fetal	fetal	JJ
cord-005941-e4fvj54l	526	14	human	human	JJ
cord-005941-e4fvj54l	526	15	lung	lung	NN
cord-005941-e4fvj54l	526	16	A	A	NNP
cord-005941-e4fvj54l	526	17	controlled	control	VBN
cord-005941-e4fvj54l	526	18	clinical	clinical	JJ
cord-005941-e4fvj54l	526	19	trial	trial	NN
cord-005941-e4fvj54l	526	20	of	of	IN
cord-005941-e4fvj54l	526	21	synthetic	synthetic	JJ
cord-005941-e4fvj54l	526	22	surfactant	surfactant	NN
cord-005941-e4fvj54l	526	23	in	in	IN
cord-005941-e4fvj54l	526	24	infants	infant	NNS
cord-005941-e4fvj54l	526	25	weighing	weigh	VBG
cord-005941-e4fvj54l	526	26	1250	1250	CD
cord-005941-e4fvj54l	526	27	g	g	NN
cord-005941-e4fvj54l	526	28	or	or	CC
cord-005941-e4fvj54l	526	29	more	more	JJR
cord-005941-e4fvj54l	526	30	with	with	IN
cord-005941-e4fvj54l	526	31	respiratory	respiratory	JJ
cord-005941-e4fvj54l	526	32	distress	distress	NN
cord-005941-e4fvj54l	526	33	syndrome	syndrome	NN
cord-005941-e4fvj54l	526	34	Bronchoalveolar	Bronchoalveolar	NNP
cord-005941-e4fvj54l	526	35	lavage	lavage	NN
cord-005941-e4fvj54l	526	36	lipids	lipid	NNS
cord-005941-e4fvj54l	526	37	in	in	IN
cord-005941-e4fvj54l	526	38	idiopathic	idiopathic	JJ
cord-005941-e4fvj54l	526	39	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	526	40	fibrosis	fibrosis	NN
cord-005941-e4fvj54l	527	1	Biochemical	biochemical	JJ
cord-005941-e4fvj54l	527	2	analyses	analysis	NNS
cord-005941-e4fvj54l	527	3	of	of	IN
cord-005941-e4fvj54l	527	4	bronchoalveolar	bronchoalveolar	JJ
cord-005941-e4fvj54l	527	5	lavage	lavage	NN
cord-005941-e4fvj54l	527	6	fluids	fluid	NNS
cord-005941-e4fvj54l	527	7	of	of	IN
cord-005941-e4fvj54l	527	8	healthy	healthy	JJ
cord-005941-e4fvj54l	527	9	human	human	JJ
cord-005941-e4fvj54l	527	10	volunteer	volunteer	NN
cord-005941-e4fvj54l	527	11	smokers	smoker	NNS
cord-005941-e4fvj54l	527	12	and	and	CC
cord-005941-e4fvj54l	527	13	nonsmokers	nonsmoker	NNS
cord-005941-e4fvj54l	527	14	Human	Human	NNP
cord-005941-e4fvj54l	527	15	leucocyte	leucocyte	RB
cord-005941-e4fvj54l	528	1	Clq	clq	NN
cord-005941-e4fvj54l	528	2	receptor	receptor	NN
cord-005941-e4fvj54l	528	3	binds	bind	VBZ
cord-005941-e4fvj54l	528	4	other	other	JJ
cord-005941-e4fvj54l	528	5	soluble	soluble	JJ
cord-005941-e4fvj54l	528	6	proteins	protein	NNS
cord-005941-e4fvj54l	528	7	with	with	IN
cord-005941-e4fvj54l	528	8	collagen	collagen	NN
cord-005941-e4fvj54l	528	9	domains	domain	NNS
cord-005941-e4fvj54l	528	10	Specific	specific	JJ
cord-005941-e4fvj54l	528	11	interaction	interaction	NN
cord-005941-e4fvj54l	528	12	of	of	IN
cord-005941-e4fvj54l	528	13	lung	lung	NN
cord-005941-e4fvj54l	528	14	surfactant	surfactant	NN
cord-005941-e4fvj54l	529	1	protein	protein	NN
cord-005941-e4fvj54l	529	2	A	A	NNP
cord-005941-e4fvj54l	529	3	(	(	-LRB-
cord-005941-e4fvj54l	529	4	SP	SP	NNP
cord-005941-e4fvj54l	529	5	-	-	HYPH
cord-005941-e4fvj54l	529	6	A	A	NNP
cord-005941-e4fvj54l	529	7	)	)	-RRB-
cord-005941-e4fvj54l	529	8	with	with	IN
cord-005941-e4fvj54l	529	9	rat	rat	NN
cord-005941-e4fvj54l	529	10	alveolar	alveolar	NN
cord-005941-e4fvj54l	529	11	macrophages	macrophage	NNS
cord-005941-e4fvj54l	529	12	Limitations	limitation	NNS
cord-005941-e4fvj54l	529	13	of	of	IN
cord-005941-e4fvj54l	529	14	using	use	VBG
cord-005941-e4fvj54l	529	15	urea	urea	NN
cord-005941-e4fvj54l	529	16	to	to	TO
cord-005941-e4fvj54l	529	17	quantify	quantify	VB
cord-005941-e4fvj54l	529	18	epithelial	epithelial	JJ
cord-005941-e4fvj54l	529	19	lining	lining	NN
cord-005941-e4fvj54l	529	20	fluid	fluid	NN
cord-005941-e4fvj54l	529	21	recovered	recover	VBN
cord-005941-e4fvj54l	529	22	by	by	IN
cord-005941-e4fvj54l	529	23	bronchalveolar	bronchalveolar	NNP
cord-005941-e4fvj54l	529	24	lavage	lavage	NN
cord-005941-e4fvj54l	529	25	Surfactant	Surfactant	NNP
cord-005941-e4fvj54l	529	26	in	in	IN
cord-005941-e4fvj54l	529	27	adult	adult	JJ
cord-005941-e4fvj54l	529	28	respiratory	respiratory	JJ
cord-005941-e4fvj54l	529	29	distress	distress	NN
cord-005941-e4fvj54l	529	30	syndrome	syndrome	NN
cord-005941-e4fvj54l	529	31	Surfactant	Surfactant	NNP
cord-005941-e4fvj54l	529	32	apoprotein.-A	apoprotein.-a	NN
cord-005941-e4fvj54l	529	33	concentration	concentration	NN
cord-005941-e4fvj54l	529	34	in	in	IN
cord-005941-e4fvj54l	529	35	sputum	sputum	NN
cord-005941-e4fvj54l	529	36	for	for	IN
cord-005941-e4fvj54l	529	37	diagnosis	diagnosis	NN
cord-005941-e4fvj54l	529	38	of	of	IN
cord-005941-e4fvj54l	529	39	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	529	40	alveolar	alveolar	NN
cord-005941-e4fvj54l	529	41	proteinosis	proteinosis	NN
cord-005941-e4fvj54l	529	42	Sublethal	Sublethal	NNP
cord-005941-e4fvj54l	529	43	hyperoxic	hyperoxic	JJ
cord-005941-e4fvj54l	529	44	injury	injury	NN
cord-005941-e4fvj54l	529	45	to	to	IN
cord-005941-e4fvj54l	529	46	the	the	DT
cord-005941-e4fvj54l	529	47	alveolar	alveolar	JJ
cord-005941-e4fvj54l	529	48	epithelium	epithelium	NN
cord-005941-e4fvj54l	529	49	and	and	CC
cord-005941-e4fvj54l	529	50	the	the	DT
cord-005941-e4fvj54l	529	51	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	529	52	surfactant	surfactant	NN
cord-005941-e4fvj54l	529	53	system	system	NN
cord-005941-e4fvj54l	529	54	Characterization	characterization	NN
cord-005941-e4fvj54l	529	55	of	of	IN
cord-005941-e4fvj54l	529	56	antioxidant	antioxidant	JJ
cord-005941-e4fvj54l	529	57	activities	activity	NNS
cord-005941-e4fvj54l	529	58	of	of	IN
cord-005941-e4fvj54l	529	59	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	529	60	surfactant	surfactant	NN
cord-005941-e4fvj54l	529	61	mixtures	mixture	NNS
cord-005941-e4fvj54l	529	62	Idiopathic	idiopathic	JJ
cord-005941-e4fvj54l	529	63	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	529	64	fibrosis	fibrosis	NN
cord-005941-e4fvj54l	529	65	.	.	.
cord-005941-e4fvj54l	530	1	Abnormalities	abnormality	NNS
cord-005941-e4fvj54l	530	2	in	in	IN
cord-005941-e4fvj54l	530	3	the	the	DT
cord-005941-e4fvj54l	530	4	bronchoalveotar	bronchoalveotar	NNP
cord-005941-e4fvj54l	530	5	lavage	lavage	NNP
cord-005941-e4fvj54l	530	6	content	content	NN
cord-005941-e4fvj54l	530	7	of	of	IN
cord-005941-e4fvj54l	530	8	surfacrant	surfacrant	NNP
cord-005941-e4fvj54l	530	9	protein	protein	NN
cord-005941-e4fvj54l	531	1	A	a	DT
cord-005941-e4fvj54l	531	2	Immunologic	immunologic	JJ
cord-005941-e4fvj54l	531	3	consequences	consequence	NNS
cord-005941-e4fvj54l	531	4	of	of	IN
cord-005941-e4fvj54l	531	5	exogenous	exogenous	JJ
cord-005941-e4fvj54l	531	6	surfactint	surfactint	NNP
cord-005941-e4fvj54l	531	7	administration	administration	NN
cord-005941-e4fvj54l	531	8	Degradation	degradation	NN
cord-005941-e4fvj54l	531	9	of	of	IN
cord-005941-e4fvj54l	531	10	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	531	11	surfactant	surfactant	NN
cord-005941-e4fvj54l	531	12	disaturated	disaturate	VBN
cord-005941-e4fvj54l	531	13	phosphatidylcholines	phosphatidylcholine	NNS
cord-005941-e4fvj54l	531	14	by	by	IN
cord-005941-e4fvj54l	531	15	alveolar	alveolar	NN
cord-005941-e4fvj54l	531	16	macrophages	macrophage	NNS
cord-005941-e4fvj54l	531	17	Hypertrophy	hypertrophy	NN
cord-005941-e4fvj54l	531	18	and	and	CC
cord-005941-e4fvj54l	531	19	hyperplasia	hyperplasia	NN
cord-005941-e4fvj54l	531	20	of	of	IN
cord-005941-e4fvj54l	531	21	alveolar	alveolar	JJ
cord-005941-e4fvj54l	531	22	type	type	NN
cord-005941-e4fvj54l	531	23	II	ii	CD
cord-005941-e4fvj54l	531	24	cells	cell	NNS
cord-005941-e4fvj54l	531	25	in	in	IN
cord-005941-e4fvj54l	531	26	response	response	NN
cord-005941-e4fvj54l	531	27	to	to	IN
cord-005941-e4fvj54l	531	28	silica	silica	NN
cord-005941-e4fvj54l	531	29	and	and	CC
cord-005941-e4fvj54l	531	30	other	other	JJ
cord-005941-e4fvj54l	531	31	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	531	32	toxicants	toxicant	NNS
cord-005941-e4fvj54l	531	33	Adverse	adverse	JJ
cord-005941-e4fvj54l	531	34	effects	effect	NNS
cord-005941-e4fvj54l	531	35	of	of	IN
cord-005941-e4fvj54l	531	36	toxins	toxin	NNS
cord-005941-e4fvj54l	531	37	and	and	CC
cord-005941-e4fvj54l	531	38	drugs	drug	NNS
cord-005941-e4fvj54l	531	39	on	on	IN
cord-005941-e4fvj54l	531	40	the	the	DT
cord-005941-e4fvj54l	531	41	surfactant	surfactant	NN
cord-005941-e4fvj54l	531	42	systems	system	NNS
cord-005941-e4fvj54l	531	43	Causes	cause	NNS
cord-005941-e4fvj54l	531	44	of	of	IN
cord-005941-e4fvj54l	531	45	mortality	mortality	NN
cord-005941-e4fvj54l	531	46	in	in	IN
cord-005941-e4fvj54l	531	47	patients	patient	NNS
cord-005941-e4fvj54l	531	48	with	with	IN
cord-005941-e4fvj54l	531	49	the	the	DT
cord-005941-e4fvj54l	531	50	adult	adult	NN
cord-005941-e4fvj54l	531	51	respiratory	respiratory	JJ
cord-005941-e4fvj54l	531	52	distress	distress	NN
cord-005941-e4fvj54l	531	53	syndrome	syndrome	NN
cord-005941-e4fvj54l	531	54	Toxicological	toxicological	JJ
cord-005941-e4fvj54l	531	55	data	datum	NNS
cord-005941-e4fvj54l	531	56	on	on	IN
cord-005941-e4fvj54l	531	57	NOx	NOx	NNP
cord-005941-e4fvj54l	531	58	:	:	:
cord-005941-e4fvj54l	531	59	an	an	DT
cord-005941-e4fvj54l	531	60	overview	overview	NN
cord-005941-e4fvj54l	531	61	Pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	531	62	surfactant	surfactant	NN
cord-005941-e4fvj54l	531	63	:	:	:
cord-005941-e4fvj54l	531	64	physiology	physiology	NN
cord-005941-e4fvj54l	531	65	,	,	,
cord-005941-e4fvj54l	531	66	pharmacology	pharmacology	NN
cord-005941-e4fvj54l	531	67	and	and	CC
cord-005941-e4fvj54l	531	68	clinical	clinical	JJ
cord-005941-e4fvj54l	531	69	uses	use	VBZ
cord-005941-e4fvj54l	531	70	Exogenous	exogenous	JJ
cord-005941-e4fvj54l	531	71	surfactant	surfactant	NN
cord-005941-e4fvj54l	531	72	treatment	treatment	NN
cord-005941-e4fvj54l	531	73	for	for	IN
cord-005941-e4fvj54l	531	74	the	the	DT
cord-005941-e4fvj54l	531	75	adult	adult	NN
cord-005941-e4fvj54l	531	76	respiratory	respiratory	JJ
cord-005941-e4fvj54l	531	77	distress	distress	NN
cord-005941-e4fvj54l	531	78	syndrome	syndrome	NN
cord-005941-e4fvj54l	531	79	?	?	.
cord-005941-e4fvj54l	532	1	A	a	DT
cord-005941-e4fvj54l	532	2	historical	historical	JJ
cord-005941-e4fvj54l	532	3	perspective	perspective	NN
cord-005941-e4fvj54l	532	4	Effects	effect	NNS
cord-005941-e4fvj54l	532	5	of	of	IN
cord-005941-e4fvj54l	532	6	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	532	7	oxygen	oxygen	NN
cord-005941-e4fvj54l	532	8	injury	injury	NN
cord-005941-e4fvj54l	532	9	on	on	IN
cord-005941-e4fvj54l	532	10	airway	airway	NN
cord-005941-e4fvj54l	532	11	content	content	NN
cord-005941-e4fvj54l	532	12	of	of	IN
cord-005941-e4fvj54l	532	13	surfactant	surfactant	NN
cord-005941-e4fvj54l	532	14	-	-	HYPH
cord-005941-e4fvj54l	532	15	associated	associate	VBN
cord-005941-e4fvj54l	532	16	protein	protein	NN
cord-005941-e4fvj54l	532	17	A	A	NNP
cord-005941-e4fvj54l	532	18	Surfactant	Surfactant	NNP
cord-005941-e4fvj54l	532	19	for	for	IN
cord-005941-e4fvj54l	532	20	adults	adult	NNS
cord-005941-e4fvj54l	532	21	with	with	IN
cord-005941-e4fvj54l	532	22	respiratory	respiratory	JJ
cord-005941-e4fvj54l	532	23	failure	failure	NN
cord-005941-e4fvj54l	532	24	Surfactant	Surfactant	NNP
cord-005941-e4fvj54l	532	25	analysis	analysis	NN
cord-005941-e4fvj54l	532	26	and	and	CC
cord-005941-e4fvj54l	532	27	replacement	replacement	NN
cord-005941-e4fvj54l	532	28	therapy	therapy	NN
cord-005941-e4fvj54l	532	29	:	:	:
cord-005941-e4fvj54l	532	30	a	a	DT
cord-005941-e4fvj54l	532	31	future	future	JJ
cord-005941-e4fvj54l	532	32	tool	tool	NN
cord-005941-e4fvj54l	532	33	of	of	IN
cord-005941-e4fvj54l	532	34	the	the	DT
cord-005941-e4fvj54l	532	35	lung	lung	NN
cord-005941-e4fvj54l	532	36	transplant	transplant	NN
cord-005941-e4fvj54l	532	37	surgeon	surgeon	NN
cord-005941-e4fvj54l	532	38	Surfactant	Surfactant	NNP
cord-005941-e4fvj54l	532	39	treatments	treatment	NNS
cord-005941-e4fvj54l	532	40	alter	alter	VBP
cord-005941-e4fvj54l	532	41	endogenous	endogenous	JJ
cord-005941-e4fvj54l	532	42	surfactant	surfactant	NN
cord-005941-e4fvj54l	532	43	metabolism	metabolism	NN
cord-005941-e4fvj54l	532	44	in	in	IN
cord-005941-e4fvj54l	532	45	rabbit	rabbit	NN
cord-005941-e4fvj54l	532	46	lungs	lung	NNS
cord-005941-e4fvj54l	533	1	Bacteremia	Bacteremia	NNP
cord-005941-e4fvj54l	533	2	-	-	HYPH
cord-005941-e4fvj54l	533	3	induced	induce	VBN
cord-005941-e4fvj54l	533	4	suppression	suppression	NN
cord-005941-e4fvj54l	533	5	of	of	IN
cord-005941-e4fvj54l	533	6	alveolar	alveolar	JJ
cord-005941-e4fvj54l	533	7	surfactant	surfactant	NN
cord-005941-e4fvj54l	533	8	production	production	NN
cord-005941-e4fvj54l	533	9	Rat	Rat	NNP
cord-005941-e4fvj54l	533	10	lung	lung	NN
cord-005941-e4fvj54l	533	11	lavage	lavage	NN
cord-005941-e4fvj54l	533	12	surfactant	surfactant	NN
cord-005941-e4fvj54l	533	13	enhances	enhance	VBZ
cord-005941-e4fvj54l	533	14	bacterial	bacterial	JJ
cord-005941-e4fvj54l	533	15	phagocytosis	phagocytosis	NN
cord-005941-e4fvj54l	533	16	and	and	CC
cord-005941-e4fvj54l	533	17	intracellular	intracellular	JJ
cord-005941-e4fvj54l	533	18	killing	killing	NN
cord-005941-e4fvj54l	533	19	by	by	IN
cord-005941-e4fvj54l	533	20	alveolar	alveolar	NN
cord-005941-e4fvj54l	533	21	macrophages	macrophage	NNS
cord-005941-e4fvj54l	533	22	Structural	structural	JJ
cord-005941-e4fvj54l	533	23	and	and	CC
cord-005941-e4fvj54l	533	24	functional	functional	JJ
cord-005941-e4fvj54l	533	25	changes	change	NNS
cord-005941-e4fvj54l	533	26	of	of	IN
cord-005941-e4fvj54l	533	27	surfactant	surfactant	NN
cord-005941-e4fvj54l	533	28	protein	protein	NN
cord-005941-e4fvj54l	533	29	A	a	DT
cord-005941-e4fvj54l	533	30	induced	induce	VBN
cord-005941-e4fvj54l	533	31	by	by	IN
cord-005941-e4fvj54l	533	32	ozone	ozone	NN
cord-005941-e4fvj54l	533	33	Changes	change	NNS
cord-005941-e4fvj54l	533	34	of	of	IN
cord-005941-e4fvj54l	533	35	lung	lung	NN
cord-005941-e4fvj54l	533	36	surfactant	surfactant	NN
cord-005941-e4fvj54l	533	37	and	and	CC
cord-005941-e4fvj54l	533	38	pressure	pressure	NN
cord-005941-e4fvj54l	533	39	-	-	HYPH
cord-005941-e4fvj54l	533	40	volume	volume	NN
cord-005941-e4fvj54l	533	41	curve	curve	NN
cord-005941-e4fvj54l	533	42	in	in	IN
cord-005941-e4fvj54l	533	43	bleomycin	bleomycin	NN
cord-005941-e4fvj54l	533	44	-	-	HYPH
cord-005941-e4fvj54l	533	45	induced	induce	VBN
cord-005941-e4fvj54l	533	46	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	533	47	fibrosis	fibrosis	NN
cord-005941-e4fvj54l	533	48	Effects	effect	NNS
cord-005941-e4fvj54l	533	49	of	of	IN
cord-005941-e4fvj54l	533	50	smoke	smoke	NN
cord-005941-e4fvj54l	533	51	inhalation	inhalation	NN
cord-005941-e4fvj54l	533	52	on	on	IN
cord-005941-e4fvj54l	533	53	surfactant	surfactant	NN
cord-005941-e4fvj54l	533	54	phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	533	55	and	and	CC
cord-005941-e4fvj54l	533	56	phospholipase	phospholipase	NN
cord-005941-e4fvj54l	533	57	A2	A2	NNP
cord-005941-e4fvj54l	533	58	activity	activity	NN
cord-005941-e4fvj54l	533	59	in	in	IN
cord-005941-e4fvj54l	533	60	the	the	DT
cord-005941-e4fvj54l	533	61	mouse	mouse	NN
cord-005941-e4fvj54l	533	62	lung	lung	NN
cord-005941-e4fvj54l	533	63	Properties	Properties	NNPS
cord-005941-e4fvj54l	533	64	,	,	,
cord-005941-e4fvj54l	533	65	function	function	NN
cord-005941-e4fvj54l	533	66	and	and	CC
cord-005941-e4fvj54l	533	67	origin	origin	NN
cord-005941-e4fvj54l	533	68	of	of	IN
cord-005941-e4fvj54l	533	69	the	the	DT
cord-005941-e4fvj54l	533	70	alveolar	alveolar	NN
cord-005941-e4fvj54l	533	71	lining	lining	NN
cord-005941-e4fvj54l	533	72	layer	layer	NN
cord-005941-e4fvj54l	534	1	The	the	DT
cord-005941-e4fvj54l	534	2	relation	relation	NN
cord-005941-e4fvj54l	534	3	between	between	IN
cord-005941-e4fvj54l	534	4	surface	surface	NN
cord-005941-e4fvj54l	534	5	tension	tension	NN
cord-005941-e4fvj54l	534	6	and	and	CC
cord-005941-e4fvj54l	534	7	area	area	NN
cord-005941-e4fvj54l	534	8	in	in	IN
cord-005941-e4fvj54l	534	9	the	the	DT
cord-005941-e4fvj54l	534	10	alveolar	alveolar	JJ
cord-005941-e4fvj54l	534	11	lining	lining	NN
cord-005941-e4fvj54l	534	12	film	film	NN
cord-005941-e4fvj54l	534	13	Purification	purification	NN
cord-005941-e4fvj54l	534	14	and	and	CC
cord-005941-e4fvj54l	534	15	biochemical	biochemical	JJ
cord-005941-e4fvj54l	534	16	characterization	characterization	NN
cord-005941-e4fvj54l	534	17	of	of	IN
cord-005941-e4fvj54l	534	18	CP4	CP4	NNP
cord-005941-e4fvj54l	534	19	(	(	-LRB-
cord-005941-e4fvj54l	534	20	SP	SP	NNP
cord-005941-e4fvj54l	534	21	-	-	HYPH
cord-005941-e4fvj54l	534	22	D	D	NNP
cord-005941-e4fvj54l	534	23	)	)	-RRB-
cord-005941-e4fvj54l	534	24	,	,	,
cord-005941-e4fvj54l	534	25	a	a	DT
cord-005941-e4fvj54l	534	26	collagenous	collagenous	JJ
cord-005941-e4fvj54l	534	27	surfactant	surfactant	NN
cord-005941-e4fvj54l	534	28	-	-	HYPH
cord-005941-e4fvj54l	534	29	associated	associate	VBN
cord-005941-e4fvj54l	534	30	protein	protein	NN
cord-005941-e4fvj54l	534	31	Surfactant	Surfactant	NNP
cord-005941-e4fvj54l	534	32	protein	protein	NN
cord-005941-e4fvj54l	534	33	D	d	NN
cord-005941-e4fvj54l	534	34	is	be	VBZ
cord-005941-e4fvj54l	534	35	a	a	DT
cord-005941-e4fvj54l	534	36	divalent	divalent	JJ
cord-005941-e4fvj54l	534	37	cation	cation	NN
cord-005941-e4fvj54l	534	38	-	-	HYPH
cord-005941-e4fvj54l	534	39	dependent	dependent	JJ
cord-005941-e4fvj54l	534	40	carbohydrate	carbohydrate	NN
cord-005941-e4fvj54l	534	41	-	-	HYPH
cord-005941-e4fvj54l	534	42	binding	bind	VBG
cord-005941-e4fvj54l	534	43	protein	protein	NN
cord-005941-e4fvj54l	534	44	Clearance	clearance	NN
cord-005941-e4fvj54l	534	45	of	of	IN
cord-005941-e4fvj54l	534	46	surfactant	surfactant	NN
cord-005941-e4fvj54l	534	47	phosphatidylcholine	phosphatidylcholine	NN
cord-005941-e4fvj54l	534	48	from	from	IN
cord-005941-e4fvj54l	534	49	adult	adult	NN
cord-005941-e4fvj54l	534	50	rabbit	rabbit	NN
cord-005941-e4fvj54l	534	51	lungs	lung	NNS
cord-005941-e4fvj54l	534	52	Clearance	clearance	NN
cord-005941-e4fvj54l	534	53	of	of	IN
cord-005941-e4fvj54l	534	54	surfactant	surfactant	NN
cord-005941-e4fvj54l	534	55	phosphatidylcholine	phosphatidylcholine	NN
cord-005941-e4fvj54l	534	56	via	via	IN
cord-005941-e4fvj54l	534	57	the	the	DT
cord-005941-e4fvj54l	534	58	upper	upper	JJ
cord-005941-e4fvj54l	534	59	airways	airway	NNS
cord-005941-e4fvj54l	534	60	in	in	IN
cord-005941-e4fvj54l	534	61	rabbits	rabbit	NNS
cord-005941-e4fvj54l	534	62	Localization	Localization	NNP
cord-005941-e4fvj54l	534	63	of	of	IN
cord-005941-e4fvj54l	534	64	surfactant	surfactant	NN
cord-005941-e4fvj54l	534	65	protein	protein	NN
cord-005941-e4fvj54l	534	66	synthesis	synthesis	NN
cord-005941-e4fvj54l	534	67	in	in	IN
cord-005941-e4fvj54l	534	68	human	human	JJ
cord-005941-e4fvj54l	534	69	lung	lung	NN
cord-005941-e4fvj54l	534	70	by	by	IN
cord-005941-e4fvj54l	534	71	in	in	IN
cord-005941-e4fvj54l	534	72	situ	situ	NN
cord-005941-e4fvj54l	534	73	hybridization	hybridization	NN
cord-005941-e4fvj54l	534	74	Increased	increase	VBN
cord-005941-e4fvj54l	534	75	recovery	recovery	NN
cord-005941-e4fvj54l	534	76	of	of	IN
cord-005941-e4fvj54l	534	77	surfactant	surfactant	NN
cord-005941-e4fvj54l	534	78	protein	protein	NN
cord-005941-e4fvj54l	534	79	A	A	NNP
cord-005941-e4fvj54l	534	80	in	in	IN
cord-005941-e4fvj54l	534	81	AIDS	AIDS	NNP
cord-005941-e4fvj54l	534	82	-	-	HYPH
cord-005941-e4fvj54l	534	83	related	relate	VBN
cord-005941-e4fvj54l	534	84	pneumonia	pneumonia	NN
cord-005941-e4fvj54l	534	85	Surfactant	surfactant	NN
cord-005941-e4fvj54l	534	86	abnormalities	abnormality	NNS
cord-005941-e4fvj54l	534	87	in	in	IN
cord-005941-e4fvj54l	534	88	patients	patient	NNS
cord-005941-e4fvj54l	534	89	with	with	IN
cord-005941-e4fvj54l	534	90	respiratory	respiratory	JJ
cord-005941-e4fvj54l	534	91	failure	failure	NN
cord-005941-e4fvj54l	534	92	after	after	IN
cord-005941-e4fvj54l	534	93	multiple	multiple	JJ
cord-005941-e4fvj54l	534	94	trauma	trauma	NN
cord-005941-e4fvj54l	534	95	Altered	alter	VBN
cord-005941-e4fvj54l	534	96	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	534	97	surfactant	surfactant	NN
cord-005941-e4fvj54l	534	98	in	in	IN
cord-005941-e4fvj54l	534	99	uncomplicated	uncomplicated	JJ
cord-005941-e4fvj54l	534	100	and	and	CC
cord-005941-e4fvj54l	534	101	septicemia	septicemia	NN
cord-005941-e4fvj54l	534	102	-	-	HYPH
cord-005941-e4fvj54l	534	103	complicated	complicate	VBN
cord-005941-e4fvj54l	534	104	courses	course	NNS
cord-005941-e4fvj54l	534	105	of	of	IN
cord-005941-e4fvj54l	534	106	acute	acute	JJ
cord-005941-e4fvj54l	534	107	respiratory	respiratory	JJ
cord-005941-e4fvj54l	534	108	failure	failure	NN
cord-005941-e4fvj54l	535	1	A	a	DT
cord-005941-e4fvj54l	535	2	proposed	propose	VBN
cord-005941-e4fvj54l	535	3	nomenclature	nomenclature	NN
cord-005941-e4fvj54l	535	4	for	for	IN
cord-005941-e4fvj54l	535	5	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	535	6	surfactant	surfactant	NN
cord-005941-e4fvj54l	535	7	-	-	HYPH
cord-005941-e4fvj54l	535	8	associated	associate	VBN
cord-005941-e4fvj54l	535	9	proteins	protein	NNS
cord-005941-e4fvj54l	536	1	The	the	DT
cord-005941-e4fvj54l	536	2	role	role	NN
cord-005941-e4fvj54l	536	3	of	of	IN
cord-005941-e4fvj54l	536	4	surfactant	surfactant	NN
cord-005941-e4fvj54l	536	5	-	-	HYPH
cord-005941-e4fvj54l	536	6	associated	associate	VBN
cord-005941-e4fvj54l	536	7	proteins	protein	NNS
cord-005941-e4fvj54l	536	8	Biochemical	biochemical	JJ
cord-005941-e4fvj54l	536	9	modification	modification	NN
cord-005941-e4fvj54l	536	10	of	of	IN
cord-005941-e4fvj54l	536	11	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	536	12	surfactant	surfactant	NN
cord-005941-e4fvj54l	536	13	after	after	IN
cord-005941-e4fvj54l	536	14	bromhexine	bromhexine	NNP
cord-005941-e4fvj54l	536	15	derivatc	derivatc	NNP
cord-005941-e4fvj54l	536	16	injection	injection	NN
cord-005941-e4fvj54l	536	17	Rheological	Rheological	NNP
cord-005941-e4fvj54l	536	18	and	and	CC
cord-005941-e4fvj54l	536	19	transport	transport	NN
cord-005941-e4fvj54l	536	20	properties	property	NNS
cord-005941-e4fvj54l	536	21	of	of	IN
cord-005941-e4fvj54l	536	22	airway	airway	NN
cord-005941-e4fvj54l	536	23	secretions	secretion	NNS
cord-005941-e4fvj54l	536	24	in	in	IN
cord-005941-e4fvj54l	536	25	cystic	cystic	JJ
cord-005941-e4fvj54l	536	26	fibrosis	fibrosis	NN
cord-005941-e4fvj54l	536	27	-relationships	-relationships	:
cord-005941-e4fvj54l	536	28	with	with	IN
cord-005941-e4fvj54l	536	29	the	the	DT
cord-005941-e4fvj54l	536	30	degree	degree	NN
cord-005941-e4fvj54l	536	31	of	of	IN
cord-005941-e4fvj54l	536	32	infection	infection	NN
cord-005941-e4fvj54l	536	33	and	and	CC
cord-005941-e4fvj54l	536	34	severity	severity	NN
cord-005941-e4fvj54l	536	35	of	of	IN
cord-005941-e4fvj54l	536	36	the	the	DT
cord-005941-e4fvj54l	536	37	disease	disease	NN
cord-005941-e4fvj54l	536	38	Changes	change	NNS
cord-005941-e4fvj54l	536	39	in	in	IN
cord-005941-e4fvj54l	536	40	lipids	lipid	NNS
cord-005941-e4fvj54l	536	41	of	of	IN
cord-005941-e4fvj54l	536	42	lung	lung	NN
cord-005941-e4fvj54l	536	43	lavage	lavage	NN
cord-005941-e4fvj54l	536	44	in	in	IN
cord-005941-e4fvj54l	536	45	monkeys	monkey	NNS
cord-005941-e4fvj54l	536	46	after	after	IN
cord-005941-e4fvj54l	536	47	chronic	chronic	JJ
cord-005941-e4fvj54l	536	48	exposure	exposure	NN
cord-005941-e4fvj54l	536	49	to	to	IN
cord-005941-e4fvj54l	536	50	ambient	ambient	JJ
cord-005941-e4fvj54l	536	51	levels	level	NNS
cord-005941-e4fvj54l	536	52	of	of	IN
cord-005941-e4fvj54l	536	53	ozone	ozone	NN
cord-005941-e4fvj54l	536	54	Immunologic	immunologic	JJ
cord-005941-e4fvj54l	536	55	system	system	NN
cord-005941-e4fvj54l	536	56	in	in	IN
cord-005941-e4fvj54l	536	57	the	the	DT
cord-005941-e4fvj54l	536	58	respiratory	respiratory	JJ
cord-005941-e4fvj54l	536	59	tract	tract	NN
cord-005941-e4fvj54l	536	60	Pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	536	61	surfactant	surfactant	NN
cord-005941-e4fvj54l	536	62	as	as	IN
cord-005941-e4fvj54l	536	63	a	a	DT
cord-005941-e4fvj54l	536	64	physiologic	physiologic	JJ
cord-005941-e4fvj54l	536	65	immunosuppressive	immunosuppressive	JJ
cord-005941-e4fvj54l	536	66	agent	agent	NN
cord-005941-e4fvj54l	536	67	Curstedt	Curstedt	NNP
cord-005941-e4fvj54l	536	68	T	T	NNP
cord-005941-e4fvj54l	536	69	(	(	-LRB-
cord-005941-e4fvj54l	536	70	1989	1989	CD
cord-005941-e4fvj54l	536	71	)	)	-RRB-
cord-005941-e4fvj54l	537	1	The	the	DT
cord-005941-e4fvj54l	537	2	adult	adult	NN
cord-005941-e4fvj54l	537	3	respiratory	respiratory	JJ
cord-005941-e4fvj54l	537	4	distress	distress	NN
cord-005941-e4fvj54l	537	5	syndrome	syndrome	NN
cord-005941-e4fvj54l	537	6	:	:	:
cord-005941-e4fvj54l	538	1	first	first	JJ
cord-005941-e4fvj54l	538	2	trials	trial	NNS
cord-005941-e4fvj54l	538	3	with	with	IN
cord-005941-e4fvj54l	538	4	surfactant	surfactant	NN
cord-005941-e4fvj54l	538	5	replacement	replacement	NN
cord-005941-e4fvj54l	538	6	Pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	538	7	surfactant	surfactant	NN
cord-005941-e4fvj54l	538	8	suppresses	suppress	VBZ
cord-005941-e4fvj54l	538	9	the	the	DT
cord-005941-e4fvj54l	538	10	immune	immune	JJ
cord-005941-e4fvj54l	538	11	lung	lung	NN
cord-005941-e4fvj54l	538	12	injury	injury	NN
cord-005941-e4fvj54l	538	13	response	response	NN
cord-005941-e4fvj54l	538	14	to	to	IN
cord-005941-e4fvj54l	538	15	inhaled	inhale	VBN
cord-005941-e4fvj54l	538	16	antigen	antigen	NN
cord-005941-e4fvj54l	538	17	in	in	IN
cord-005941-e4fvj54l	538	18	guinea	guinea	NN
cord-005941-e4fvj54l	538	19	pigs	pig	NNS
cord-005941-e4fvj54l	539	1	Idiopathic	idiopathic	JJ
cord-005941-e4fvj54l	539	2	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	539	3	fibrosis	fibrosis	NN
cord-005941-e4fvj54l	540	1	-abnormalities	-abnormalities	.
cord-005941-e4fvj54l	541	1	in	in	IN
cord-005941-e4fvj54l	541	2	bronchoalveolar	bronchoalveolar	NNP
cord-005941-e4fvj54l	541	3	lavage	lavage	NN
cord-005941-e4fvj54l	541	4	fluid	fluid	NN
cord-005941-e4fvj54l	542	1	The	the	DT
cord-005941-e4fvj54l	542	2	surfactant	surfactant	NN
cord-005941-e4fvj54l	542	3	system	system	NN
cord-005941-e4fvj54l	542	4	of	of	IN
cord-005941-e4fvj54l	542	5	the	the	DT
cord-005941-e4fvj54l	542	6	lung	lung	NN
cord-005941-e4fvj54l	542	7	Changes	change	NNS
cord-005941-e4fvj54l	542	8	in	in	IN
cord-005941-e4fvj54l	542	9	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	542	10	surfactant	surfactant	NN
cord-005941-e4fvj54l	542	11	composition	composition	NN
cord-005941-e4fvj54l	542	12	following	follow	VBG
cord-005941-e4fvj54l	542	13	MACC	MACC	NNP
cord-005941-e4fvj54l	542	14	chemotherapy	chemotherapy	NN
cord-005941-e4fvj54l	542	15	for	for	IN
cord-005941-e4fvj54l	542	16	lung	lung	NN
cord-005941-e4fvj54l	542	17	carcinoma	carcinoma	NN
cord-005941-e4fvj54l	542	18	Binding	Binding	NNP
cord-005941-e4fvj54l	542	19	and	and	CC
cord-005941-e4fvj54l	542	20	uptake	uptake	NN
cord-005941-e4fvj54l	542	21	of	of	IN
cord-005941-e4fvj54l	542	22	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	542	23	surfactant	surfactant	NN
cord-005941-e4fvj54l	542	24	protein	protein	NN
cord-005941-e4fvj54l	542	25	(	(	-LRB-
cord-005941-e4fvj54l	542	26	SP	SP	NNP
cord-005941-e4fvj54l	542	27	-	-	HYPH
cord-005941-e4fvj54l	542	28	A	A	NNP
cord-005941-e4fvj54l	542	29	)	)	-RRB-
cord-005941-e4fvj54l	542	30	by	by	IN
cord-005941-e4fvj54l	542	31	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	542	32	type	type	NN
cord-005941-e4fvj54l	542	33	II	ii	CD
cord-005941-e4fvj54l	542	34	epithelial	epithelial	JJ
cord-005941-e4fvj54l	542	35	cells	cell	NNS
cord-005941-e4fvj54l	542	36	Lung	lung	NN
cord-005941-e4fvj54l	542	37	surfactant	surfactant	NN
cord-005941-e4fvj54l	542	38	:	:	:
cord-005941-e4fvj54l	542	39	a	a	DT
cord-005941-e4fvj54l	542	40	biotechnological	biotechnological	JJ
cord-005941-e4fvj54l	542	41	challenge	challenge	NN
cord-005941-e4fvj54l	543	1	Alveolar	alveolar	NN
cord-005941-e4fvj54l	543	2	macrophage	macrophage	NN
cord-005941-e4fvj54l	543	3	migration	migration	NN
cord-005941-e4fvj54l	543	4	-influence	-influence	NN
cord-005941-e4fvj54l	543	5	of	of	IN
cord-005941-e4fvj54l	543	6	lung	lung	NN
cord-005941-e4fvj54l	543	7	lining	lining	NN
cord-005941-e4fvj54l	543	8	material	material	NN
cord-005941-e4fvj54l	543	9	Alteration	alteration	NN
cord-005941-e4fvj54l	543	10	of	of	IN
cord-005941-e4fvj54l	543	11	surfactant	surfactant	NN
cord-005941-e4fvj54l	543	12	function	function	NN
cord-005941-e4fvj54l	543	13	due	due	IN
cord-005941-e4fvj54l	543	14	to	to	IN
cord-005941-e4fvj54l	543	15	protein	protein	NN
cord-005941-e4fvj54l	543	16	leakage	leakage	NN
cord-005941-e4fvj54l	543	17	:	:	:
cord-005941-e4fvj54l	543	18	special	special	JJ
cord-005941-e4fvj54l	543	19	interaction	interaction	NN
cord-005941-e4fvj54l	543	20	with	with	IN
cord-005941-e4fvj54l	543	21	fibrin	fibrin	NN
cord-005941-e4fvj54l	543	22	monomer	monomer	NN
cord-005941-e4fvj54l	543	23	Surfactant	surfactant	NN
cord-005941-e4fvj54l	543	24	abnormalities	abnormality	NNS
cord-005941-e4fvj54l	543	25	and	and	CC
cord-005941-e4fvj54l	543	26	adult	adult	NN
cord-005941-e4fvj54l	543	27	respiratory	respiratory	JJ
cord-005941-e4fvj54l	543	28	failure	failure	NN
cord-005941-e4fvj54l	543	29	Surfactant	Surfactant	NNP
cord-005941-e4fvj54l	543	30	phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	543	31	and	and	CC
cord-005941-e4fvj54l	543	32	lavage	lavage	NN
cord-005941-e4fvj54l	543	33	phospholipase	phospholipase	NNP
cord-005941-e4fvj54l	543	34	A2	A2	NNP
cord-005941-e4fvj54l	543	35	in	in	IN
cord-005941-e4fvj54l	543	36	experimental	experimental	JJ
cord-005941-e4fvj54l	543	37	Pneumocystis	Pneumocystis	NNP
cord-005941-e4fvj54l	543	38	carinii	carinii	FW
cord-005941-e4fvj54l	543	39	pneumonia	pneumonia	NN
cord-005941-e4fvj54l	543	40	Giant	Giant	NNP
cord-005941-e4fvj54l	543	41	lamellar	lamellar	JJ
cord-005941-e4fvj54l	543	42	bodies	body	NNS
cord-005941-e4fvj54l	543	43	in	in	IN
cord-005941-e4fvj54l	543	44	alveolar	alveolar	JJ
cord-005941-e4fvj54l	543	45	type	type	NN
cord-005941-e4fvj54l	543	46	II	ii	CD
cord-005941-e4fvj54l	543	47	cells	cell	NNS
cord-005941-e4fvj54l	543	48	of	of	IN
cord-005941-e4fvj54l	543	49	rats	rat	NNS
cord-005941-e4fvj54l	543	50	exposed	expose	VBN
cord-005941-e4fvj54l	543	51	to	to	IN
cord-005941-e4fvj54l	543	52	a	a	DT
cord-005941-e4fvj54l	543	53	low	low	JJ
cord-005941-e4fvj54l	543	54	concentration	concentration	NN
cord-005941-e4fvj54l	543	55	of	of	IN
cord-005941-e4fvj54l	543	56	ozone	ozone	NN
cord-005941-e4fvj54l	544	1	The	the	DT
cord-005941-e4fvj54l	544	2	effect	effect	NN
cord-005941-e4fvj54l	544	3	of	of	IN
cord-005941-e4fvj54l	544	4	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	544	5	surface	surface	NN
cord-005941-e4fvj54l	544	6	-	-	HYPH
cord-005941-e4fvj54l	544	7	active	active	JJ
cord-005941-e4fvj54l	544	8	material	material	NN
cord-005941-e4fvj54l	544	9	on	on	IN
cord-005941-e4fvj54l	544	10	the	the	DT
cord-005941-e4fvj54l	544	11	generation	generation	NN
cord-005941-e4fvj54l	544	12	and	and	CC
cord-005941-e4fvj54l	544	13	expression	expression	NN
cord-005941-e4fvj54l	544	14	of	of	IN
cord-005941-e4fvj54l	544	15	murine	murine	JJ
cord-005941-e4fvj54l	544	16	B	b	NN
cord-005941-e4fvj54l	544	17	-	-	:
cord-005941-e4fvj54l	544	18	and	and	CC
cord-005941-e4fvj54l	544	19	T	t	NN
cord-005941-e4fvj54l	544	20	-	-	HYPH
cord-005941-e4fvj54l	544	21	lymphocyte	lymphocyte	NN
cord-005941-e4fvj54l	544	22	effector	effector	NN
cord-005941-e4fvj54l	544	23	functions	function	NNS
cord-005941-e4fvj54l	544	24	in	in	IN
cord-005941-e4fvj54l	544	25	vitro	vitro	FW
cord-005941-e4fvj54l	544	26	Isolation	isolation	NN
cord-005941-e4fvj54l	544	27	and	and	CC
cord-005941-e4fvj54l	544	28	characterization	characterization	NN
cord-005941-e4fvj54l	544	29	of	of	IN
cord-005941-e4fvj54l	544	30	a	a	DT
cord-005941-e4fvj54l	544	31	sulfated	sulfated	JJ
cord-005941-e4fvj54l	544	32	glyceroglucolipid	glyceroglucolipid	NN
cord-005941-e4fvj54l	544	33	from	from	IN
cord-005941-e4fvj54l	544	34	alveolar	alveolar	JJ
cord-005941-e4fvj54l	544	35	lavage	lavage	NN
cord-005941-e4fvj54l	544	36	of	of	IN
cord-005941-e4fvj54l	544	37	rabbit	rabbit	NN
cord-005941-e4fvj54l	544	38	Early	early	RB
cord-005941-e4fvj54l	544	39	versus	versus	IN
cord-005941-e4fvj54l	544	40	late	late	JJ
cord-005941-e4fvj54l	544	41	surfactant	surfactant	NN
cord-005941-e4fvj54l	544	42	replacement	replacement	NN
cord-005941-e4fvj54l	544	43	therapy	therapy	NN
cord-005941-e4fvj54l	544	44	in	in	IN
cord-005941-e4fvj54l	544	45	severe	severe	JJ
cord-005941-e4fvj54l	544	46	respiratory	respiratory	JJ
cord-005941-e4fvj54l	544	47	distress	distress	NN
cord-005941-e4fvj54l	544	48	syndrome	syndrome	NN
cord-005941-e4fvj54l	544	49	Surfactant	Surfactant	NNP
cord-005941-e4fvj54l	544	50	replacement	replacement	NN
cord-005941-e4fvj54l	544	51	:	:	:
cord-005941-e4fvj54l	544	52	immunological	immunological	JJ
cord-005941-e4fvj54l	544	53	considerations	consideration	NNS
cord-005941-e4fvj54l	544	54	Surfactant	Surfactant	NNP
cord-005941-e4fvj54l	544	55	abnormality	abnormality	NN
cord-005941-e4fvj54l	544	56	after	after	IN
cord-005941-e4fvj54l	544	57	endotoxin	endotoxin	NN
cord-005941-e4fvj54l	544	58	-	-	HYPH
cord-005941-e4fvj54l	544	59	induced	induce	VBN
cord-005941-e4fvj54l	544	60	lung	lung	NN
cord-005941-e4fvj54l	544	61	injury	injury	NN
cord-005941-e4fvj54l	544	62	in	in	IN
cord-005941-e4fvj54l	544	63	guinea	guinea	NN
cord-005941-e4fvj54l	544	64	pigs	pig	NNS
cord-005941-e4fvj54l	544	65	Structure	Structure	NNP
cord-005941-e4fvj54l	544	66	-	-	HYPH
cord-005941-e4fvj54l	544	67	function	function	NN
cord-005941-e4fvj54l	544	68	relationships	relationship	NNS
cord-005941-e4fvj54l	544	69	of	of	IN
cord-005941-e4fvj54l	544	70	bovine	bovine	JJ
cord-005941-e4fvj54l	544	71	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	544	72	surfactant	surfactant	NN
cord-005941-e4fvj54l	544	73	proteins	protein	NNS
cord-005941-e4fvj54l	544	74	SP	SP	NNP
cord-005941-e4fvj54l	544	75	-	-	HYPH
cord-005941-e4fvj54l	544	76	B	B	NNP
cord-005941-e4fvj54l	544	77	and	and	CC
cord-005941-e4fvj54l	544	78	SP	SP	NNP
cord-005941-e4fvj54l	544	79	-	-	HYPH
cord-005941-e4fvj54l	544	80	C	C	NNP
cord-005941-e4fvj54l	545	1	The	the	DT
cord-005941-e4fvj54l	545	2	proximal	proximal	JJ
cord-005941-e4fvj54l	545	3	border	border	NN
cord-005941-e4fvj54l	545	4	of	of	IN
cord-005941-e4fvj54l	545	5	the	the	DT
cord-005941-e4fvj54l	545	6	human	human	JJ
cord-005941-e4fvj54l	545	7	respiratory	respiratory	JJ
cord-005941-e4fvj54l	545	8	unit	unit	NN
cord-005941-e4fvj54l	545	9	,	,	,
cord-005941-e4fvj54l	545	10	as	as	IN
cord-005941-e4fvj54l	545	11	shown	show	VBN
cord-005941-e4fvj54l	545	12	by	by	IN
cord-005941-e4fvj54l	545	13	scanning	scanning	NN
cord-005941-e4fvj54l	545	14	and	and	CC
cord-005941-e4fvj54l	545	15	transmission	transmission	NN
cord-005941-e4fvj54l	545	16	electron	electron	NN
cord-005941-e4fvj54l	545	17	microscopy	microscopy	NN
cord-005941-e4fvj54l	545	18	and	and	CC
cord-005941-e4fvj54l	545	19	light	light	JJ
cord-005941-e4fvj54l	545	20	microscopical	microscopical	NN
cord-005941-e4fvj54l	545	21	cytochemistry	cytochemistry	NNP
cord-005941-e4fvj54l	545	22	Human	Human	NNP
cord-005941-e4fvj54l	545	23	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	545	24	surfactant	surfactant	NN
cord-005941-e4fvj54l	545	25	protein	protein	NN
cord-005941-e4fvj54l	545	26	(	(	-LRB-
cord-005941-e4fvj54l	545	27	SP	SP	NNP
cord-005941-e4fvj54l	545	28	-	-	HYPH
cord-005941-e4fvj54l	545	29	A	A	NNP
cord-005941-e4fvj54l	545	30	)	)	-RRB-
cord-005941-e4fvj54l	545	31	,	,	,
cord-005941-e4fvj54l	545	32	a	a	DT
cord-005941-e4fvj54l	545	33	protein	protein	NN
cord-005941-e4fvj54l	545	34	structurally	structurally	RB
cord-005941-e4fvj54l	545	35	homologous	homologous	JJ
cord-005941-e4fvj54l	545	36	to	to	IN
cord-005941-e4fvj54l	545	37	Clq	Clq	NNP
cord-005941-e4fvj54l	545	38	,	,	,
cord-005941-e4fvj54l	545	39	can	can	MD
cord-005941-e4fvj54l	545	40	enhance	enhance	VB
cord-005941-e4fvj54l	545	41	FcR	fcr	NN
cord-005941-e4fvj54l	545	42	-	-	:
cord-005941-e4fvj54l	545	43	and	and	CC
cord-005941-e4fvj54l	545	44	CRl	crl	NN
cord-005941-e4fvj54l	545	45	-	-	HYPH
cord-005941-e4fvj54l	545	46	mediated	mediate	VBN
cord-005941-e4fvj54l	545	47	phagocytosis	phagocytosis	NN
cord-005941-e4fvj54l	545	48	Altered	alter	VBD
cord-005941-e4fvj54l	545	49	lipid	lipid	NN
cord-005941-e4fvj54l	545	50	synthesis	synthesis	NN
cord-005941-e4fvj54l	545	51	in	in	IN
cord-005941-e4fvj54l	545	52	type	type	NN
cord-005941-e4fvj54l	545	53	II	II	NNP
cord-005941-e4fvj54l	545	54	pneumocytes	pneumocyte	NNS
cord-005941-e4fvj54l	545	55	exposed	expose	VBN
cord-005941-e4fvj54l	545	56	to	to	IN
cord-005941-e4fvj54l	545	57	lung	lung	NN
cord-005941-e4fvj54l	545	58	surfactant	surfactant	NN
cord-005941-e4fvj54l	545	59	Correlation	correlation	NN
cord-005941-e4fvj54l	545	60	of	of	IN
cord-005941-e4fvj54l	545	61	changes	change	NNS
cord-005941-e4fvj54l	545	62	in	in	IN
cord-005941-e4fvj54l	545	63	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	545	64	surfactant	surfactant	NN
cord-005941-e4fvj54l	545	65	phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	545	66	with	with	IN
cord-005941-e4fvj54l	545	67	compliance	compliance	NN
cord-005941-e4fvj54l	545	68	in	in	IN
cord-005941-e4fvj54l	545	69	bleomycin	bleomycin	NN
cord-005941-e4fvj54l	545	70	-	-	HYPH
cord-005941-e4fvj54l	545	71	induced	induce	VBN
cord-005941-e4fvj54l	545	72	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	545	73	fibrosis	fibrosis	NN
cord-005941-e4fvj54l	545	74	in	in	IN
cord-005941-e4fvj54l	545	75	the	the	DT
cord-005941-e4fvj54l	545	76	rat	rat	NN
cord-005941-e4fvj54l	545	77	Synthesis	Synthesis	NNP
cord-005941-e4fvj54l	545	78	of	of	IN
cord-005941-e4fvj54l	545	79	surfactant	surfactant	NN
cord-005941-e4fvj54l	545	80	lipids	lipid	NNS
cord-005941-e4fvj54l	545	81	in	in	IN
cord-005941-e4fvj54l	545	82	the	the	DT
cord-005941-e4fvj54l	545	83	adult	adult	NN
cord-005941-e4fvj54l	545	84	and	and	CC
cord-005941-e4fvj54l	545	85	fetal	fetal	JJ
cord-005941-e4fvj54l	545	86	lung	lung	NN
cord-005941-e4fvj54l	545	87	:	:	:
cord-005941-e4fvj54l	545	88	pathways	pathway	NNS
cord-005941-e4fvj54l	545	89	and	and	CC
cord-005941-e4fvj54l	545	90	regulatory	regulatory	JJ
cord-005941-e4fvj54l	545	91	aspects	aspect	NNS
cord-005941-e4fvj54l	545	92	Metabolism	metabolism	NN
cord-005941-e4fvj54l	545	93	of	of	IN
cord-005941-e4fvj54l	545	94	phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	545	95	in	in	IN
cord-005941-e4fvj54l	545	96	the	the	DT
cord-005941-e4fvj54l	545	97	lung	lung	NN
cord-005941-e4fvj54l	545	98	Aspects	aspect	NNS
cord-005941-e4fvj54l	545	99	of	of	IN
cord-005941-e4fvj54l	545	100	metabolism	metabolism	NN
cord-005941-e4fvj54l	545	101	and	and	CC
cord-005941-e4fvj54l	545	102	storage	storage	NN
cord-005941-e4fvj54l	545	103	of	of	IN
cord-005941-e4fvj54l	545	104	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	545	105	surfactant	surfactant	NN
cord-005941-e4fvj54l	545	106	:	:	:
cord-005941-e4fvj54l	545	107	experiments	experiment	NNS
cord-005941-e4fvj54l	545	108	with	with	IN
cord-005941-e4fvj54l	545	109	isolated	isolated	JJ
cord-005941-e4fvj54l	545	110	type	type	NN
cord-005941-e4fvj54l	545	111	II	II	NNP
cord-005941-e4fvj54l	545	112	pneumocytes	pneumocyte	NNS
cord-005941-e4fvj54l	545	113	and	and	CC
cord-005941-e4fvj54l	545	114	lamellar	lamellar	JJ
cord-005941-e4fvj54l	545	115	bodies	body	NNS
cord-005941-e4fvj54l	546	1	Pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	546	2	surfactant	surfactant	NN
cord-005941-e4fvj54l	546	3	protein	protein	NN
cord-005941-e4fvj54l	546	4	A	A	NNP
cord-005941-e4fvj54l	546	5	enhances	enhance	VBZ
cord-005941-e4fvj54l	546	6	the	the	DT
cord-005941-e4fvj54l	546	7	host	host	NN
cord-005941-e4fvj54l	546	8	-	-	HYPH
cord-005941-e4fvj54l	546	9	defence	defence	NN
cord-005941-e4fvj54l	546	10	mechanism	mechanism	NN
cord-005941-e4fvj54l	546	11	of	of	IN
cord-005941-e4fvj54l	546	12	rat	rat	NN
cord-005941-e4fvj54l	546	13	alveolar	alveolar	NN
cord-005941-e4fvj54l	546	14	macrophages	macrophage	NNS
cord-005941-e4fvj54l	546	15	Surfactant	Surfactant	NNP
cord-005941-e4fvj54l	546	16	protein	protein	NN
cord-005941-e4fvj54l	546	17	A	a	NN
cord-005941-e4fvj54l	547	1	is	be	VBZ
cord-005941-e4fvj54l	547	2	opsonin	opsonin	NNP
cord-005941-e4fvj54l	547	3	in	in	IN
cord-005941-e4fvj54l	547	4	phagocytosis	phagocytosis	NN
cord-005941-e4fvj54l	547	5	of	of	IN
cord-005941-e4fvj54l	547	6	herpes	herpes	NNP
cord-005941-e4fvj54l	547	7	simplex	simplex	NNP
cord-005941-e4fvj54l	547	8	virus	virus	NN
cord-005941-e4fvj54l	547	9	type	type	NN
cord-005941-e4fvj54l	547	10	1	1	CD
cord-005941-e4fvj54l	547	11	by	by	IN
cord-005941-e4fvj54l	547	12	rat	rat	NN
cord-005941-e4fvj54l	547	13	alveolar	alveolar	NN
cord-005941-e4fvj54l	547	14	macrophages	macrophage	NNS
cord-005941-e4fvj54l	547	15	Enhancement	Enhancement	NNP
cord-005941-e4fvj54l	547	16	of	of	IN
cord-005941-e4fvj54l	547	17	biophysical	biophysical	JJ
cord-005941-e4fvj54l	547	18	activity	activity	NN
cord-005941-e4fvj54l	547	19	of	of	IN
cord-005941-e4fvj54l	547	20	lung	lung	NN
cord-005941-e4fvj54l	547	21	surfactant	surfactant	NN
cord-005941-e4fvj54l	547	22	extracts	extract	NNS
cord-005941-e4fvj54l	547	23	and	and	CC
cord-005941-e4fvj54l	547	24	phospholipid	phospholipid	NN
cord-005941-e4fvj54l	547	25	-	-	HYPH
cord-005941-e4fvj54l	547	26	apoprotein	apoprotein	NN
cord-005941-e4fvj54l	547	27	mixtures	mixture	NNS
cord-005941-e4fvj54l	547	28	by	by	IN
cord-005941-e4fvj54l	547	29	surfactant	surfactant	NN
cord-005941-e4fvj54l	547	30	protein	protein	NN
cord-005941-e4fvj54l	547	31	A	a	NN
cord-005941-e4fvj54l	548	1	Neue	Neue	NNP
cord-005941-e4fvj54l	548	2	Auffassungen	Auffassungen	NNP
cord-005941-e4fvj54l	548	3	fiber	fiber	NN
cord-005941-e4fvj54l	548	4	einen	einen	NNP
cord-005941-e4fvj54l	548	5	Grundbegriff	Grundbegriff	NNP
cord-005941-e4fvj54l	548	6	der	der	NNP
cord-005941-e4fvj54l	548	7	Atemmechanik	Atemmechanik	NNP
cord-005941-e4fvj54l	548	8	Surfactant	Surfactant	NNP
cord-005941-e4fvj54l	548	9	protein	protein	NN
cord-005941-e4fvj54l	548	10	A	A	NNP
cord-005941-e4fvj54l	548	11	is	be	VBZ
cord-005941-e4fvj54l	548	12	localized	localize	VBN
cord-005941-e4fvj54l	548	13	at	at	IN
cord-005941-e4fvj54l	548	14	the	the	DT
cord-005941-e4fvj54l	548	15	corners	corner	NNS
cord-005941-e4fvj54l	548	16	of	of	IN
cord-005941-e4fvj54l	548	17	the	the	DT
cord-005941-e4fvj54l	548	18	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	548	19	tubular	tubular	JJ
cord-005941-e4fvj54l	548	20	myelin	myelin	NN
cord-005941-e4fvj54l	548	21	lattice	lattice	NN
cord-005941-e4fvj54l	548	22	Macromolecular	Macromolecular	NNP
cord-005941-e4fvj54l	548	23	organization	organization	NN
cord-005941-e4fvj54l	548	24	of	of	IN
cord-005941-e4fvj54l	548	25	natural	natural	JJ
cord-005941-e4fvj54l	548	26	and	and	CC
cord-005941-e4fvj54l	548	27	recombinant	recombinant	JJ
cord-005941-e4fvj54l	548	28	lung	lung	NN
cord-005941-e4fvj54l	548	29	surfactant	surfactant	NN
cord-005941-e4fvj54l	548	30	protein	protein	NN
cord-005941-e4fvj54l	548	31	SP	SP	NNP
cord-005941-e4fvj54l	548	32	28	28	CD
cord-005941-e4fvj54l	548	33	-	-	SYM
cord-005941-e4fvj54l	548	34	36	36	CD
cord-005941-e4fvj54l	548	35	Structural	structural	JJ
cord-005941-e4fvj54l	548	36	comparison	comparison	NN
cord-005941-e4fvj54l	548	37	of	of	IN
cord-005941-e4fvj54l	548	38	recombinant	recombinant	JJ
cord-005941-e4fvj54l	548	39	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	548	40	surfactant	surfactant	NN
cord-005941-e4fvj54l	548	41	protein	protein	NN
cord-005941-e4fvj54l	548	42	SP	SP	NNP
cord-005941-e4fvj54l	548	43	-	-	HYPH
cord-005941-e4fvj54l	548	44	A	A	NNP
cord-005941-e4fvj54l	548	45	derived	derive	VBN
cord-005941-e4fvj54l	548	46	from	from	IN
cord-005941-e4fvj54l	548	47	two	two	CD
cord-005941-e4fvj54l	548	48	human	human	JJ
cord-005941-e4fvj54l	548	49	coding	coding	NN
cord-005941-e4fvj54l	548	50	sequences	sequence	NNS
cord-005941-e4fvj54l	548	51	:	:	:
cord-005941-e4fvj54l	548	52	implications	implication	NNS
cord-005941-e4fvj54l	548	53	for	for	IN
cord-005941-e4fvj54l	548	54	the	the	DT
cord-005941-e4fvj54l	548	55	chain	chain	NN
cord-005941-e4fvj54l	548	56	composition	composition	NN
cord-005941-e4fvj54l	548	57	of	of	IN
cord-005941-e4fvj54l	548	58	natural	natural	JJ
cord-005941-e4fvj54l	548	59	human	human	JJ
cord-005941-e4fvj54l	548	60	SP	SP	NNP
cord-005941-e4fvj54l	548	61	-	-	HYPH
cord-005941-e4fvj54l	548	62	A	A	NNP
cord-005941-e4fvj54l	548	63	Surfactant	Surfactant	NNP
cord-005941-e4fvj54l	548	64	proteins	protein	NNS
cord-005941-e4fvj54l	548	65	and	and	CC
cord-005941-e4fvj54l	548	66	SP	SP	NNP
cord-005941-e4fvj54l	548	67	-	-	HYPH
cord-005941-e4fvj54l	548	68	D	D	NNP
cord-005941-e4fvj54l	548	69	Function	function	NN
cord-005941-e4fvj54l	548	70	and	and	CC
cord-005941-e4fvj54l	548	71	regulation	regulation	NN
cord-005941-e4fvj54l	548	72	of	of	IN
cord-005941-e4fvj54l	548	73	expression	expression	NN
cord-005941-e4fvj54l	548	74	of	of	IN
cord-005941-e4fvj54l	548	75	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	548	76	surfactant	surfactant	NN
cord-005941-e4fvj54l	548	77	-	-	HYPH
cord-005941-e4fvj54l	548	78	associated	associate	VBN
cord-005941-e4fvj54l	548	79	proteins	protein	NNS
cord-005941-e4fvj54l	548	80	Identification	Identification	NNP
cord-005941-e4fvj54l	548	81	of	of	IN
cord-005941-e4fvj54l	548	82	surfactant	surfactant	NN
cord-005941-e4fvj54l	548	83	proteolipid	proteolipid	NN
cord-005941-e4fvj54l	548	84	SP	SP	NNP
cord-005941-e4fvj54l	548	85	-	-	HYPH
cord-005941-e4fvj54l	548	86	B	B	NNP
cord-005941-e4fvj54l	548	87	in	in	IN
cord-005941-e4fvj54l	548	88	human	human	JJ
cord-005941-e4fvj54l	548	89	surfactant	surfactant	NN
cord-005941-e4fvj54l	548	90	and	and	CC
cord-005941-e4fvj54l	548	91	fetal	fetal	JJ
cord-005941-e4fvj54l	548	92	lung	lung	NN
cord-005941-e4fvj54l	548	93	Mesalazine	Mesalazine	NNP
cord-005941-e4fvj54l	548	94	alveolitis	alveolitis	NN
cord-005941-e4fvj54l	548	95	Isolation	isolation	NN
cord-005941-e4fvj54l	548	96	and	and	CC
cord-005941-e4fvj54l	548	97	characterization	characterization	NN
cord-005941-e4fvj54l	548	98	of	of	IN
cord-005941-e4fvj54l	548	99	the	the	DT
cord-005941-e4fvj54l	548	100	human	human	JJ
cord-005941-e4fvj54l	548	101	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	548	102	surfactant	surfactant	NN
cord-005941-e4fvj54l	548	103	apoprotein	apoprotein	NNP
cord-005941-e4fvj54l	548	104	gene	gene	NN
cord-005941-e4fvj54l	548	105	Glycosylation	Glycosylation	NNP
cord-005941-e4fvj54l	548	106	and	and	CC
cord-005941-e4fvj54l	548	107	secretion	secretion	NN
cord-005941-e4fvj54l	548	108	of	of	IN
cord-005941-e4fvj54l	548	109	surfactant	surfactant	NN
cord-005941-e4fvj54l	548	110	-	-	HYPH
cord-005941-e4fvj54l	548	111	associated	associate	VBN
cord-005941-e4fvj54l	548	112	glycoprotein	glycoprotein	NN
cord-005941-e4fvj54l	548	113	A	a	DT
cord-005941-e4fvj54l	548	114	Endobronchial	Endobronchial	NNP
cord-005941-e4fvj54l	548	115	surface	surface	NN
cord-005941-e4fvj54l	548	116	active	active	JJ
cord-005941-e4fvj54l	548	117	phospholipids	phospholipid	NNS
cord-005941-e4fvj54l	548	118	:	:	:
cord-005941-e4fvj54l	548	119	clinical	clinical	JJ
cord-005941-e4fvj54l	548	120	conclusions	conclusion	NNS
cord-005941-e4fvj54l	549	1	Changes	change	NNS
cord-005941-e4fvj54l	549	2	in	in	IN
cord-005941-e4fvj54l	549	3	lipid	lipid	NN
cord-005941-e4fvj54l	549	4	structure	structure	NN
cord-005941-e4fvj54l	549	5	produced	produce	VBN
cord-005941-e4fvj54l	549	6	by	by	IN
cord-005941-e4fvj54l	549	7	surfactant	surfactant	NN
cord-005941-e4fvj54l	549	8	proteins	protein	NNS
cord-005941-e4fvj54l	549	9	SP	SP	NNP
cord-005941-e4fvj54l	549	10	-	-	HYPH
cord-005941-e4fvj54l	549	11	A	A	NNP
cord-005941-e4fvj54l	549	12	,	,	,
cord-005941-e4fvj54l	549	13	SP	SP	NNP
cord-005941-e4fvj54l	549	14	-	-	HYPH
cord-005941-e4fvj54l	549	15	B	B	NNP
cord-005941-e4fvj54l	549	16	,	,	,
cord-005941-e4fvj54l	549	17	and	and	CC
cord-005941-e4fvj54l	549	18	SP	SP	NNP
cord-005941-e4fvj54l	549	19	-	-	HYPH
cord-005941-e4fvj54l	549	20	C	C	NNP
cord-005941-e4fvj54l	549	21	Immunoregulatory	Immunoregulatory	NNP
cord-005941-e4fvj54l	549	22	properties	property	NNS
cord-005941-e4fvj54l	549	23	of	of	IN
cord-005941-e4fvj54l	549	24	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	549	25	surfactant	surfactant	NN
cord-005941-e4fvj54l	549	26	:	:	:
cord-005941-e4fvj54l	549	27	effect	effect	NN
cord-005941-e4fvj54l	549	28	of	of	IN
cord-005941-e4fvj54l	549	29	lung	lung	NN
cord-005941-e4fvj54l	549	30	lining	lining	NN
cord-005941-e4fvj54l	549	31	fluid	fluid	NN
cord-005941-e4fvj54l	549	32	on	on	IN
cord-005941-e4fvj54l	549	33	proliferation	proliferation	NN
cord-005941-e4fvj54l	549	34	of	of	IN
cord-005941-e4fvj54l	549	35	human	human	JJ
cord-005941-e4fvj54l	549	36	blood	blood	NN
cord-005941-e4fvj54l	549	37	lymphocytes	lymphocyte	NNS
cord-005941-e4fvj54l	549	38	Immunosuppression	Immunosuppression	NNP
cord-005941-e4fvj54l	549	39	by	by	IN
cord-005941-e4fvj54l	549	40	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	549	41	surfactant	surfactant	NN
cord-005941-e4fvj54l	549	42	:	:	:
cord-005941-e4fvj54l	549	43	mechanisms	mechanism	NNS
cord-005941-e4fvj54l	549	44	of	of	IN
cord-005941-e4fvj54l	549	45	action	action	NN
cord-005941-e4fvj54l	549	46	Relations	relation	NNS
cord-005941-e4fvj54l	549	47	among	among	IN
cord-005941-e4fvj54l	549	48	recoil	recoil	NN
cord-005941-e4fvj54l	549	49	pressure	pressure	NN
cord-005941-e4fvj54l	549	50	,	,	,
cord-005941-e4fvj54l	549	51	surface	surface	NN
cord-005941-e4fvj54l	549	52	area	area	NN
cord-005941-e4fvj54l	549	53	,	,	,
cord-005941-e4fvj54l	549	54	and	and	CC
cord-005941-e4fvj54l	549	55	surface	surface	NN
cord-005941-e4fvj54l	549	56	tension	tension	NN
cord-005941-e4fvj54l	549	57	in	in	IN
cord-005941-e4fvj54l	549	58	the	the	DT
cord-005941-e4fvj54l	549	59	lung	lung	NN
cord-005941-e4fvj54l	549	60	Effects	effect	NNS
cord-005941-e4fvj54l	549	61	of	of	IN
cord-005941-e4fvj54l	549	62	short	short	JJ
cord-005941-e4fvj54l	549	63	-	-	HYPH
cord-005941-e4fvj54l	549	64	term	term	NN
cord-005941-e4fvj54l	549	65	exposure	exposure	NN
cord-005941-e4fvj54l	549	66	to	to	IN
cord-005941-e4fvj54l	549	67	diesel	diesel	NN
cord-005941-e4fvj54l	549	68	exhaust	exhaust	NN
cord-005941-e4fvj54l	549	69	on	on	IN
cord-005941-e4fvj54l	549	70	lung	lung	NN
cord-005941-e4fvj54l	549	71	cell	cell	NN
cord-005941-e4fvj54l	549	72	proliferation	proliferation	NN
cord-005941-e4fvj54l	549	73	and	and	CC
cord-005941-e4fvj54l	549	74	phospholipid	phospholipid	NN
cord-005941-e4fvj54l	549	75	metabolism	metabolism	NN
cord-005941-e4fvj54l	549	76	Clearance	clearance	NN
cord-005941-e4fvj54l	549	77	and	and	CC
cord-005941-e4fvj54l	549	78	recycling	recycling	NN
cord-005941-e4fvj54l	549	79	of	of	IN
cord-005941-e4fvj54l	549	80	pulmonary	pulmonary	JJ
cord-005941-e4fvj54l	549	81	surfactant	surfactant	NN
cord-005941-e4fvj54l	549	82	Metabolism	metabolism	NN
cord-005941-e4fvj54l	549	83	and	and	CC
cord-005941-e4fvj54l	549	84	turnover	turnover	NN
cord-005941-e4fvj54l	549	85	of	of	IN
cord-005941-e4fvj54l	549	86	lung	lung	NN
cord-005941-e4fvj54l	549	87	surfactant	surfactant	NN
cord-005941-e4fvj54l	549	88	Surfactant	Surfactant	NNP
cord-005941-e4fvj54l	549	89	apoprotein	apoprotein	NNP
cord-005941-e4fvj54l	549	90	Mr=26.000	Mr=26.000	NNP
cord-005941-e4fvj54l	549	91	-	-	HYPH
cord-005941-e4fvj54l	549	92	36.000	36.000	CD
cord-005941-e4fvj54l	549	93	enhances	enhance	VBZ
cord-005941-e4fvj54l	549	94	uptake	uptake	NN
cord-005941-e4fvj54l	549	95	of	of	IN
cord-005941-e4fvj54l	549	96	liposomes	liposome	NNS
cord-005941-e4fvj54l	549	97	by	by	IN
cord-005941-e4fvj54l	549	98	type	type	NN
cord-005941-e4fvj54l	549	99	II	II	NNP
cord-005941-e4fvj54l	549	100	ceils	ceils	NNPS
cord-005941-e4fvj54l	549	101	Role	role	NN
cord-005941-e4fvj54l	549	102	of	of	IN
cord-005941-e4fvj54l	549	103	bovine	bovine	JJ
cord-005941-e4fvj54l	549	104	pulmonaryassociated	pulmonaryassociated	JJ
cord-005941-e4fvj54l	549	105	proteins	protein	NNS
cord-005941-e4fvj54l	549	106	in	in	IN
cord-005941-e4fvj54l	549	107	the	the	DT
cord-005941-e4fvj54l	549	108	surface	surface	NN
cord-005941-e4fvj54l	549	109	active	active	JJ
cord-005941-e4fvj54l	549	110	property	property	NN
cord-005941-e4fvj54l	549	111	of	of	IN
cord-005941-e4fvj54l	549	112	phospholipid	phospholipid	NN
cord-005941-e4fvj54l	549	113	mixtures	mixture	NNS
cord-005941-e4fvj54l	549	114	Effects	effect	NNS
cord-005941-e4fvj54l	549	115	of	of	IN
cord-005941-e4fvj54l	549	116	aerosolized	aerosolize	VBN
cord-005941-e4fvj54l	549	117	artificial	artificial	JJ
cord-005941-e4fvj54l	549	118	surfactant	surfactant	NN
cord-005941-e4fvj54l	549	119	on	on	IN
cord-005941-e4fvj54l	549	120	repeated	repeat	VBN
cord-005941-e4fvj54l	549	121	oleic	oleic	JJ
cord-005941-e4fvj54l	549	122	acid	acid	NN
cord-005941-e4fvj54l	549	123	injury	injury	NN
cord-005941-e4fvj54l	549	124	in	in	IN
cord-005941-e4fvj54l	549	125	sheep	sheep	NN
cord-005941-e4fvj54l	549	126	Acknowledgements	acknowledgement	NNS
cord-005941-e4fvj54l	549	127	.	.	.
cord-005941-e4fvj54l	550	1	We	-PRON-	PRP
cord-005941-e4fvj54l	550	2	would	would	MD
cord-005941-e4fvj54l	550	3	like	like	VB
cord-005941-e4fvj54l	550	4	to	to	TO
cord-005941-e4fvj54l	550	5	thank	thank	VB
cord-005941-e4fvj54l	550	6	Prof.	Prof.	NNP
cord-005941-e4fvj54l	550	7	K.	K.	NNP
cord-005941-e4fvj54l	550	8	Morgenroth	Morgenroth	NNP
cord-005941-e4fvj54l	550	9	,	,	,
cord-005941-e4fvj54l	550	10	Ruhr	Ruhr	NNP
cord-005941-e4fvj54l	550	11	-	-	HYPH
cord-005941-e4fvj54l	550	12	Universitfit	Universitfit	NNP
cord-005941-e4fvj54l	550	13	Bochum	Bochum	NNP
cord-005941-e4fvj54l	550	14	,	,	,
cord-005941-e4fvj54l	550	15	for	for	IN
cord-005941-e4fvj54l	550	16	the	the	DT
cord-005941-e4fvj54l	550	17	excellent	excellent	JJ
cord-005941-e4fvj54l	550	18	electron	electron	NN
cord-005941-e4fvj54l	550	19	mi	mi	JJ
cord-005941-e4fvj54l	550	20	-	-	HYPH
cord-005941-e4fvj54l	550	21	croscopic	croscopic	JJ
cord-005941-e4fvj54l	550	22	photographs	photograph	NNS
cord-005941-e4fvj54l	550	23	(	(	-LRB-
cord-005941-e4fvj54l	550	24	Figs	fig	NNS
cord-005941-e4fvj54l	550	25	.	.	.
cord-005941-e4fvj54l	551	1	2	2	LS
cord-005941-e4fvj54l	551	2	-	-	SYM
cord-005941-e4fvj54l	551	3	4	4	CD
cord-005941-e4fvj54l	551	4	)	)	-RRB-
cord-005941-e4fvj54l	552	1	and	and	CC
cord-005941-e4fvj54l	552	2	Prof.	Prof.	NNP
cord-005941-e4fvj54l	552	3	Schfifer	Schfifer	NNP
cord-005941-e4fvj54l	552	4	(	(	-LRB-
cord-005941-e4fvj54l	552	5	Byk	Byk	NNP
cord-005941-e4fvj54l	552	6	-	-	HYPH
cord-005941-e4fvj54l	552	7	Gulden	Gulden	NNP
cord-005941-e4fvj54l	552	8	Co.	Co.	NNP
cord-005941-e4fvj54l	552	9	,	,	,
cord-005941-e4fvj54l	552	10	Konstanz	Konstanz	NNP
cord-005941-e4fvj54l	552	11	,	,	,
cord-005941-e4fvj54l	552	12	Germany	Germany	NNP
cord-005941-e4fvj54l	552	13	)	)	-RRB-
cord-005941-e4fvj54l	552	14	,	,	,
cord-005941-e4fvj54l	552	15	Prof.	Prof.	NNP
cord-005941-e4fvj54l	552	16	Akino	Akino	NNP
cord-005941-e4fvj54l	552	17	and	and	CC
cord-005941-e4fvj54l	552	18	Prof.	Prof.	NNP
cord-005941-e4fvj54l	552	19	Kuroki	Kuroki	NNP
cord-005941-e4fvj54l	552	20	(	(	-LRB-
cord-005941-e4fvj54l	552	21	Sapporo	Sapporo	NNP
cord-005941-e4fvj54l	552	22	Medical	Medical	NNP
cord-005941-e4fvj54l	552	23	College	College	NNP
cord-005941-e4fvj54l	552	24	,	,	,
cord-005941-e4fvj54l	552	25	Japan	Japan	NNP
cord-005941-e4fvj54l	552	26	)	)	-RRB-
cord-005941-e4fvj54l	552	27	for	for	IN
cord-005941-e4fvj54l	552	28	aiding	aid	VBG
cord-005941-e4fvj54l	552	29	our	-PRON-	PRP$
cord-005941-e4fvj54l	552	30	laboratory	laboratory	NN
cord-005941-e4fvj54l	552	31	with	with	IN
cord-005941-e4fvj54l	552	32	SP	SP	NNP
cord-005941-e4fvj54l	552	33	-	-	HYPH
cord-005941-e4fvj54l	552	34	A	a	DT
cord-005941-e4fvj54l	552	35	antigen	antigen	NN
cord-005941-e4fvj54l	552	36	and	and	CC
cord-005941-e4fvj54l	552	37	antibodies	antibody	NNS
cord-005941-e4fvj54l	552	38	.	.	.