id	sid	tid	token	lemma	pos
cord-012045-1cqqj84n	1	1	key	key	NN
cord-012045-1cqqj84n	1	2	:	:	:
cord-012045-1cqqj84n	2	1	cord-012045	cord-012045	NNP
cord-012045-1cqqj84n	2	2	-	-	HYPH
cord-012045-1cqqj84n	2	3	1cqqj84n	1cqqj84n	CD
cord-012045-1cqqj84n	2	4	authors	author	NNS
cord-012045-1cqqj84n	2	5	:	:	:
cord-012045-1cqqj84n	2	6	Li	Li	NNP
cord-012045-1cqqj84n	2	7	,	,	,
cord-012045-1cqqj84n	2	8	Tiao	Tiao	NNP
cord-012045-1cqqj84n	2	9	;	;	:
cord-012045-1cqqj84n	2	10	Zou	Zou	NNP
cord-012045-1cqqj84n	3	1	,	,	,
cord-012045-1cqqj84n	3	2	Chunbin	Chunbin	NNP
cord-012045-1cqqj84n	3	3	title	title	NN
cord-012045-1cqqj84n	3	4	:	:	:
cord-012045-1cqqj84n	4	1	The	the	DT
cord-012045-1cqqj84n	4	2	Role	role	NN
cord-012045-1cqqj84n	4	3	of	of	IN
cord-012045-1cqqj84n	4	4	Deubiquitinating	Deubiquitinating	NNP
cord-012045-1cqqj84n	4	5	Enzymes	Enzymes	NNPS
cord-012045-1cqqj84n	4	6	in	in	IN
cord-012045-1cqqj84n	4	7	Acute	Acute	NNP
cord-012045-1cqqj84n	4	8	Lung	Lung	NNP
cord-012045-1cqqj84n	4	9	Injury	Injury	NNP
cord-012045-1cqqj84n	4	10	and	and	CC
cord-012045-1cqqj84n	4	11	Acute	acute	JJ
cord-012045-1cqqj84n	4	12	Respiratory	Respiratory	NNP
cord-012045-1cqqj84n	4	13	Distress	Distress	NNP
cord-012045-1cqqj84n	4	14	Syndrome	Syndrome	NNP
cord-012045-1cqqj84n	4	15	date	date	NN
cord-012045-1cqqj84n	4	16	:	:	:
cord-012045-1cqqj84n	4	17	2020	2020	CD
cord-012045-1cqqj84n	4	18	-	-	HYPH
cord-012045-1cqqj84n	4	19	07	07	CD
cord-012045-1cqqj84n	4	20	-	-	HYPH
cord-012045-1cqqj84n	4	21	08	08	CD
cord-012045-1cqqj84n	4	22	journal	journal	NN
cord-012045-1cqqj84n	4	23	:	:	:
cord-012045-1cqqj84n	4	24	Int	Int	NNP
cord-012045-1cqqj84n	4	25	J	J	NNP
cord-012045-1cqqj84n	4	26	Mol	Mol	NNP
cord-012045-1cqqj84n	4	27	Sci	Sci	NNP
cord-012045-1cqqj84n	4	28	DOI	DOI	NNP
cord-012045-1cqqj84n	4	29	:	:	:
cord-012045-1cqqj84n	4	30	10.3390	10.3390	CD
cord-012045-1cqqj84n	4	31	/	/	SYM
cord-012045-1cqqj84n	4	32	ijms21144842	ijms21144842	NN
cord-012045-1cqqj84n	4	33	sha	sha	NNP
cord-012045-1cqqj84n	4	34	:	:	:
cord-012045-1cqqj84n	4	35	5c95d569a4849c256f94945737fbe3e918d8e96d	5c95d569a4849c256f94945737fbe3e918d8e96d	CD
cord-012045-1cqqj84n	4	36	doc_id	doc_id	CD
cord-012045-1cqqj84n	4	37	:	:	:
cord-012045-1cqqj84n	4	38	12045	12045	CD
cord-012045-1cqqj84n	4	39	cord_uid	cord_uid	NNS
cord-012045-1cqqj84n	4	40	:	:	:
cord-012045-1cqqj84n	5	1	1cqqj84n	1cqqj84n	LS
cord-012045-1cqqj84n	5	2	Acute	acute	JJ
cord-012045-1cqqj84n	5	3	lung	lung	NN
cord-012045-1cqqj84n	5	4	injury	injury	NN
cord-012045-1cqqj84n	5	5	and	and	CC
cord-012045-1cqqj84n	5	6	acute	acute	JJ
cord-012045-1cqqj84n	5	7	respiratory	respiratory	JJ
cord-012045-1cqqj84n	5	8	distress	distress	NN
cord-012045-1cqqj84n	5	9	syndrome	syndrome	NN
cord-012045-1cqqj84n	6	1	(	(	-LRB-
cord-012045-1cqqj84n	6	2	ALI	ALI	NNP
cord-012045-1cqqj84n	6	3	/	/	SYM
cord-012045-1cqqj84n	6	4	ARDS	ARDS	NNP
cord-012045-1cqqj84n	6	5	)	)	-RRB-
cord-012045-1cqqj84n	6	6	are	be	VBP
cord-012045-1cqqj84n	6	7	characterized	characterize	VBN
cord-012045-1cqqj84n	6	8	by	by	IN
cord-012045-1cqqj84n	6	9	an	an	DT
cord-012045-1cqqj84n	6	10	inflammatory	inflammatory	JJ
cord-012045-1cqqj84n	6	11	response	response	NN
cord-012045-1cqqj84n	6	12	,	,	,
cord-012045-1cqqj84n	6	13	alveolar	alveolar	JJ
cord-012045-1cqqj84n	6	14	edema	edema	NN
cord-012045-1cqqj84n	6	15	,	,	,
cord-012045-1cqqj84n	6	16	and	and	CC
cord-012045-1cqqj84n	6	17	hypoxemia	hypoxemia	NN
cord-012045-1cqqj84n	6	18	.	.	.
cord-012045-1cqqj84n	7	1	ARDS	ARDS	NNP
cord-012045-1cqqj84n	7	2	occurs	occur	VBZ
cord-012045-1cqqj84n	7	3	most	most	RBS
cord-012045-1cqqj84n	7	4	often	often	RB
cord-012045-1cqqj84n	7	5	in	in	IN
cord-012045-1cqqj84n	7	6	the	the	DT
cord-012045-1cqqj84n	7	7	settings	setting	NNS
cord-012045-1cqqj84n	7	8	of	of	IN
cord-012045-1cqqj84n	7	9	pneumonia	pneumonia	NN
cord-012045-1cqqj84n	7	10	,	,	,
cord-012045-1cqqj84n	7	11	sepsis	sepsis	NN
cord-012045-1cqqj84n	7	12	,	,	,
cord-012045-1cqqj84n	7	13	aspiration	aspiration	NN
cord-012045-1cqqj84n	7	14	of	of	IN
cord-012045-1cqqj84n	7	15	gastric	gastric	JJ
cord-012045-1cqqj84n	7	16	contents	content	NNS
cord-012045-1cqqj84n	7	17	,	,	,
cord-012045-1cqqj84n	7	18	or	or	CC
cord-012045-1cqqj84n	7	19	severe	severe	JJ
cord-012045-1cqqj84n	7	20	trauma	trauma	NN
cord-012045-1cqqj84n	7	21	.	.	.
cord-012045-1cqqj84n	8	1	The	the	DT
cord-012045-1cqqj84n	8	2	prevalence	prevalence	NN
cord-012045-1cqqj84n	8	3	of	of	IN
cord-012045-1cqqj84n	8	4	ARDS	ARDS	NNP
cord-012045-1cqqj84n	8	5	is	be	VBZ
cord-012045-1cqqj84n	8	6	approximately	approximately	RB
cord-012045-1cqqj84n	8	7	10	10	CD
cord-012045-1cqqj84n	8	8	%	%	NN
cord-012045-1cqqj84n	8	9	in	in	IN
cord-012045-1cqqj84n	8	10	patients	patient	NNS
cord-012045-1cqqj84n	8	11	of	of	IN
cord-012045-1cqqj84n	8	12	intensive	intensive	JJ
cord-012045-1cqqj84n	8	13	care	care	NN
cord-012045-1cqqj84n	8	14	.	.	.
cord-012045-1cqqj84n	9	1	There	there	EX
cord-012045-1cqqj84n	9	2	is	be	VBZ
cord-012045-1cqqj84n	9	3	no	no	DT
cord-012045-1cqqj84n	9	4	effective	effective	JJ
cord-012045-1cqqj84n	9	5	remedy	remedy	NN
cord-012045-1cqqj84n	9	6	with	with	IN
cord-012045-1cqqj84n	9	7	mortality	mortality	NN
cord-012045-1cqqj84n	9	8	high	high	JJ
cord-012045-1cqqj84n	9	9	at	at	IN
cord-012045-1cqqj84n	9	10	30–40	30–40	CD
cord-012045-1cqqj84n	9	11	%	%	NN
cord-012045-1cqqj84n	9	12	.	.	.
cord-012045-1cqqj84n	10	1	Most	Most	JJS
cord-012045-1cqqj84n	10	2	functional	functional	JJ
cord-012045-1cqqj84n	10	3	proteins	protein	NNS
cord-012045-1cqqj84n	10	4	are	be	VBP
cord-012045-1cqqj84n	10	5	dynamic	dynamic	JJ
cord-012045-1cqqj84n	10	6	and	and	CC
cord-012045-1cqqj84n	10	7	stringently	stringently	RB
cord-012045-1cqqj84n	10	8	governed	govern	VBN
cord-012045-1cqqj84n	10	9	by	by	IN
cord-012045-1cqqj84n	10	10	ubiquitin	ubiquitin	JJ
cord-012045-1cqqj84n	10	11	proteasomal	proteasomal	JJ
cord-012045-1cqqj84n	10	12	degradation	degradation	NN
cord-012045-1cqqj84n	10	13	.	.	.
cord-012045-1cqqj84n	11	1	Protein	protein	NN
cord-012045-1cqqj84n	11	2	ubiquitination	ubiquitination	NN
cord-012045-1cqqj84n	11	3	is	be	VBZ
cord-012045-1cqqj84n	11	4	reversible	reversible	JJ
cord-012045-1cqqj84n	11	5	,	,	,
cord-012045-1cqqj84n	11	6	the	the	DT
cord-012045-1cqqj84n	11	7	covalently	covalently	RB
cord-012045-1cqqj84n	11	8	attached	attach	VBN
cord-012045-1cqqj84n	11	9	monoubiquitin	monoubiquitin	NNP
cord-012045-1cqqj84n	11	10	or	or	CC
cord-012045-1cqqj84n	11	11	polyubiquitin	polyubiquitin	NNP
cord-012045-1cqqj84n	11	12	moieties	moiety	NNS
cord-012045-1cqqj84n	11	13	within	within	IN
cord-012045-1cqqj84n	11	14	the	the	DT
cord-012045-1cqqj84n	11	15	targeted	target	VBN
cord-012045-1cqqj84n	11	16	protein	protein	NN
cord-012045-1cqqj84n	11	17	can	can	MD
cord-012045-1cqqj84n	11	18	be	be	VB
cord-012045-1cqqj84n	11	19	removed	remove	VBN
cord-012045-1cqqj84n	11	20	by	by	IN
cord-012045-1cqqj84n	11	21	a	a	DT
cord-012045-1cqqj84n	11	22	group	group	NN
cord-012045-1cqqj84n	11	23	of	of	IN
cord-012045-1cqqj84n	11	24	enzymes	enzyme	NNS
cord-012045-1cqqj84n	11	25	called	call	VBN
cord-012045-1cqqj84n	11	26	deubiquitinating	deubiquitinate	VBG
cord-012045-1cqqj84n	11	27	enzymes	enzyme	NNS
cord-012045-1cqqj84n	11	28	(	(	-LRB-
cord-012045-1cqqj84n	11	29	DUBs	dub	NNS
cord-012045-1cqqj84n	11	30	)	)	-RRB-
cord-012045-1cqqj84n	11	31	.	.	.
cord-012045-1cqqj84n	12	1	Deubiquitination	deubiquitination	NN
cord-012045-1cqqj84n	12	2	plays	play	VBZ
cord-012045-1cqqj84n	12	3	an	an	DT
cord-012045-1cqqj84n	12	4	important	important	JJ
cord-012045-1cqqj84n	12	5	role	role	NN
cord-012045-1cqqj84n	12	6	in	in	IN
cord-012045-1cqqj84n	12	7	the	the	DT
cord-012045-1cqqj84n	12	8	pathobiology	pathobiology	NN
cord-012045-1cqqj84n	12	9	of	of	IN
cord-012045-1cqqj84n	12	10	ALI	ALI	NNP
cord-012045-1cqqj84n	12	11	/	/	SYM
cord-012045-1cqqj84n	12	12	ARDS	ARDS	NNP
cord-012045-1cqqj84n	12	13	as	as	IN
cord-012045-1cqqj84n	12	14	it	-PRON-	PRP
cord-012045-1cqqj84n	12	15	regulates	regulate	VBZ
cord-012045-1cqqj84n	12	16	proteins	protein	NNS
cord-012045-1cqqj84n	12	17	critical	critical	JJ
cord-012045-1cqqj84n	12	18	in	in	IN
cord-012045-1cqqj84n	12	19	engagement	engagement	NN
cord-012045-1cqqj84n	12	20	of	of	IN
cord-012045-1cqqj84n	12	21	the	the	DT
cord-012045-1cqqj84n	12	22	alveolo	alveolo	NN
cord-012045-1cqqj84n	12	23	-	-	HYPH
cord-012045-1cqqj84n	12	24	capillary	capillary	JJ
cord-012045-1cqqj84n	12	25	barrier	barrier	NN
cord-012045-1cqqj84n	12	26	and	and	CC
cord-012045-1cqqj84n	12	27	in	in	IN
cord-012045-1cqqj84n	12	28	the	the	DT
cord-012045-1cqqj84n	12	29	inflammatory	inflammatory	JJ
cord-012045-1cqqj84n	12	30	response	response	NN
cord-012045-1cqqj84n	12	31	.	.	.
cord-012045-1cqqj84n	13	1	In	in	IN
cord-012045-1cqqj84n	13	2	this	this	DT
cord-012045-1cqqj84n	13	3	review	review	NN
cord-012045-1cqqj84n	13	4	,	,	,
cord-012045-1cqqj84n	13	5	we	-PRON-	PRP
cord-012045-1cqqj84n	13	6	provide	provide	VBP
cord-012045-1cqqj84n	13	7	an	an	DT
cord-012045-1cqqj84n	13	8	overview	overview	NN
cord-012045-1cqqj84n	13	9	of	of	IN
cord-012045-1cqqj84n	13	10	how	how	WRB
cord-012045-1cqqj84n	13	11	DUBs	dub	NNS
cord-012045-1cqqj84n	13	12	emerge	emerge	VBP
cord-012045-1cqqj84n	13	13	in	in	IN
cord-012045-1cqqj84n	13	14	pathogen	pathogen	NN
cord-012045-1cqqj84n	13	15	-	-	HYPH
cord-012045-1cqqj84n	13	16	induced	induce	VBN
cord-012045-1cqqj84n	13	17	pulmonary	pulmonary	JJ
cord-012045-1cqqj84n	13	18	inflammation	inflammation	NN
cord-012045-1cqqj84n	13	19	and	and	CC
cord-012045-1cqqj84n	13	20	related	relate	VBN
cord-012045-1cqqj84n	13	21	aspects	aspect	NNS
cord-012045-1cqqj84n	13	22	in	in	IN
cord-012045-1cqqj84n	13	23	ALI	ALI	NNP
cord-012045-1cqqj84n	13	24	/	/	SYM
cord-012045-1cqqj84n	13	25	ARDS	ARDS	NNP
cord-012045-1cqqj84n	13	26	.	.	.
cord-012045-1cqqj84n	14	1	Better	well	JJR
cord-012045-1cqqj84n	14	2	understanding	understanding	NN
cord-012045-1cqqj84n	14	3	of	of	IN
cord-012045-1cqqj84n	14	4	deubiquitination	deubiquitination	NN
cord-012045-1cqqj84n	14	5	-	-	HYPH
cord-012045-1cqqj84n	14	6	relatedsignaling	relatedsignaling	NN
cord-012045-1cqqj84n	14	7	may	may	MD
cord-012045-1cqqj84n	14	8	lead	lead	VB
cord-012045-1cqqj84n	14	9	to	to	IN
cord-012045-1cqqj84n	14	10	novel	novel	JJ
cord-012045-1cqqj84n	14	11	therapeutic	therapeutic	JJ
cord-012045-1cqqj84n	14	12	approaches	approach	NNS
cord-012045-1cqqj84n	14	13	by	by	IN
cord-012045-1cqqj84n	14	14	targeting	target	VBG
cord-012045-1cqqj84n	14	15	specific	specific	JJ
cord-012045-1cqqj84n	14	16	elements	element	NNS
cord-012045-1cqqj84n	14	17	of	of	IN
cord-012045-1cqqj84n	14	18	the	the	DT
cord-012045-1cqqj84n	14	19	deubiquitination	deubiquitination	NN
cord-012045-1cqqj84n	14	20	pathways	pathway	NNS
cord-012045-1cqqj84n	14	21	.	.	.
cord-012045-1cqqj84n	15	1	Acute	acute	JJ
cord-012045-1cqqj84n	15	2	lung	lung	NN
cord-012045-1cqqj84n	15	3	injury	injury	NN
cord-012045-1cqqj84n	15	4	and	and	CC
cord-012045-1cqqj84n	15	5	acute	acute	JJ
cord-012045-1cqqj84n	15	6	respiratory	respiratory	JJ
cord-012045-1cqqj84n	15	7	distress	distress	NN
cord-012045-1cqqj84n	15	8	syndrome	syndrome	NN
cord-012045-1cqqj84n	16	1	(	(	-LRB-
cord-012045-1cqqj84n	16	2	ALI	ALI	NNP
cord-012045-1cqqj84n	16	3	/	/	SYM
cord-012045-1cqqj84n	16	4	ARDS	ARDS	NNP
cord-012045-1cqqj84n	16	5	)	)	-RRB-
cord-012045-1cqqj84n	16	6	are	be	VBP
cord-012045-1cqqj84n	16	7	a	a	DT
cord-012045-1cqqj84n	16	8	group	group	NN
cord-012045-1cqqj84n	16	9	of	of	IN
cord-012045-1cqqj84n	16	10	illnesses	illness	NNS
cord-012045-1cqqj84n	16	11	with	with	IN
cord-012045-1cqqj84n	16	12	features	feature	NNS
cord-012045-1cqqj84n	16	13	of	of	IN
cord-012045-1cqqj84n	16	14	lung	lung	NN
cord-012045-1cqqj84n	16	15	inflammation	inflammation	NN
cord-012045-1cqqj84n	16	16	,	,	,
cord-012045-1cqqj84n	16	17	air	air	NN
cord-012045-1cqqj84n	16	18	-	-	HYPH
cord-012045-1cqqj84n	16	19	blood	blood	NN
cord-012045-1cqqj84n	16	20	barrier	barrier	NN
cord-012045-1cqqj84n	16	21	disfunction	disfunction	NN
cord-012045-1cqqj84n	16	22	,	,	,
cord-012045-1cqqj84n	16	23	and	and	CC
cord-012045-1cqqj84n	16	24	hypoxemia	hypoxemia	NN
cord-012045-1cqqj84n	16	25	.	.	.
cord-012045-1cqqj84n	17	1	ALI	ALI	NNP
cord-012045-1cqqj84n	17	2	/	/	SYM
cord-012045-1cqqj84n	17	3	ARDS	ARDS	NNP
cord-012045-1cqqj84n	17	4	are	be	VBP
cord-012045-1cqqj84n	17	5	life	life	NN
cord-012045-1cqqj84n	17	6	-	-	HYPH
cord-012045-1cqqj84n	17	7	threatening	threaten	VBG
cord-012045-1cqqj84n	17	8	with	with	IN
cord-012045-1cqqj84n	17	9	a	a	DT
cord-012045-1cqqj84n	17	10	severe	severe	JJ
cord-012045-1cqqj84n	17	11	public	public	JJ
cord-012045-1cqqj84n	17	12	health	health	NN
cord-012045-1cqqj84n	17	13	concern	concern	NN
cord-012045-1cqqj84n	17	14	,	,	,
cord-012045-1cqqj84n	17	15	approximately	approximately	RB
cord-012045-1cqqj84n	17	16	200,000	200,000	CD
cord-012045-1cqqj84n	17	17	people	people	NNS
cord-012045-1cqqj84n	17	18	per	per	IN
cord-012045-1cqqj84n	17	19	year	year	NN
cord-012045-1cqqj84n	17	20	develop	develop	VB
cord-012045-1cqqj84n	17	21	into	into	IN
cord-012045-1cqqj84n	17	22	ALI	ALI	NNP
cord-012045-1cqqj84n	17	23	/	/	SYM
cord-012045-1cqqj84n	17	24	ARDS	ARDS	NNP
cord-012045-1cqqj84n	17	25	in	in	IN
cord-012045-1cqqj84n	17	26	the	the	DT
cord-012045-1cqqj84n	17	27	United	United	NNP
cord-012045-1cqqj84n	17	28	States	States	NNP
cord-012045-1cqqj84n	17	29	,	,	,
cord-012045-1cqqj84n	17	30	and	and	CC
cord-012045-1cqqj84n	17	31	the	the	DT
cord-012045-1cqqj84n	17	32	mortality	mortality	NN
cord-012045-1cqqj84n	17	33	rates	rate	NNS
cord-012045-1cqqj84n	17	34	are	be	VBP
cord-012045-1cqqj84n	17	35	high	high	JJ
cord-012045-1cqqj84n	17	36	at	at	IN
cord-012045-1cqqj84n	17	37	30	30	CD
cord-012045-1cqqj84n	17	38	-	-	SYM
cord-012045-1cqqj84n	17	39	40	40	CD
cord-012045-1cqqj84n	17	40	%	%	NN
cord-012045-1cqqj84n	17	41	[	[	-LRB-
cord-012045-1cqqj84n	17	42	1	1	CD
cord-012045-1cqqj84n	17	43	]	]	-RRB-
cord-012045-1cqqj84n	17	44	[	[	-LRB-
cord-012045-1cqqj84n	17	45	2	2	CD
cord-012045-1cqqj84n	17	46	]	]	-RRB-
cord-012045-1cqqj84n	17	47	[	[	-LRB-
cord-012045-1cqqj84n	17	48	3	3	CD
cord-012045-1cqqj84n	17	49	]	]	-RRB-
cord-012045-1cqqj84n	17	50	[	[	-LRB-
cord-012045-1cqqj84n	17	51	4	4	CD
cord-012045-1cqqj84n	17	52	]	]	-RRB-
cord-012045-1cqqj84n	17	53	[	[	-LRB-
cord-012045-1cqqj84n	17	54	5	5	CD
cord-012045-1cqqj84n	17	55	]	]	-RRB-
cord-012045-1cqqj84n	17	56	.	.	.
cord-012045-1cqqj84n	18	1	It	-PRON-	PRP
cord-012045-1cqqj84n	18	2	is	be	VBZ
cord-012045-1cqqj84n	18	3	believed	believe	VBN
cord-012045-1cqqj84n	18	4	that	that	IN
cord-012045-1cqqj84n	18	5	about~10	about~10	NNP
cord-012045-1cqqj84n	18	6	%	%	NN
cord-012045-1cqqj84n	18	7	of	of	IN
cord-012045-1cqqj84n	18	8	patients	patient	NNS
cord-012045-1cqqj84n	18	9	in	in	IN
cord-012045-1cqqj84n	18	10	intensive	intensive	JJ
cord-012045-1cqqj84n	18	11	care	care	NN
cord-012045-1cqqj84n	18	12	units	unit	NNS
cord-012045-1cqqj84n	18	13	eventually	eventually	RB
cord-012045-1cqqj84n	18	14	develop	develop	VBP
cord-012045-1cqqj84n	18	15	into	into	IN
cord-012045-1cqqj84n	18	16	ALI	ALI	NNP
cord-012045-1cqqj84n	18	17	/	/	SYM
cord-012045-1cqqj84n	18	18	ARDS	ARDS	NNP
cord-012045-1cqqj84n	18	19	worldwide	worldwide	RB
cord-012045-1cqqj84n	18	20	.	.	.
cord-012045-1cqqj84n	19	1	Etiologically	etiologically	RB
cord-012045-1cqqj84n	19	2	,	,	,
cord-012045-1cqqj84n	19	3	microbial	microbial	JJ
cord-012045-1cqqj84n	19	4	pneumonia	pneumonia	NN
cord-012045-1cqqj84n	19	5	,	,	,
cord-012045-1cqqj84n	19	6	sepsis	sepsis	NN
cord-012045-1cqqj84n	19	7	,	,	,
cord-012045-1cqqj84n	19	8	aspiration	aspiration	NN
cord-012045-1cqqj84n	19	9	of	of	IN
cord-012045-1cqqj84n	19	10	gastric	gastric	JJ
cord-012045-1cqqj84n	19	11	contents	content	NNS
cord-012045-1cqqj84n	19	12	,	,	,
cord-012045-1cqqj84n	19	13	or	or	CC
cord-012045-1cqqj84n	19	14	severe	severe	JJ
cord-012045-1cqqj84n	19	15	trauma	trauma	NN
cord-012045-1cqqj84n	19	16	are	be	VBP
cord-012045-1cqqj84n	19	17	the	the	DT
cord-012045-1cqqj84n	19	18	major	major	JJ
cord-012045-1cqqj84n	19	19	causes	cause	NNS
cord-012045-1cqqj84n	19	20	of	of	IN
cord-012045-1cqqj84n	19	21	ALI	ALI	NNP
cord-012045-1cqqj84n	19	22	/	/	SYM
cord-012045-1cqqj84n	19	23	ARDS	ARDS	NNP
cord-012045-1cqqj84n	19	24	.	.	.
cord-012045-1cqqj84n	20	1	Approximately	approximately	RB
cord-012045-1cqqj84n	20	2	40	40	CD
cord-012045-1cqqj84n	20	3	%	%	NN
cord-012045-1cqqj84n	20	4	of	of	IN
cord-012045-1cqqj84n	20	5	the	the	DT
cord-012045-1cqqj84n	20	6	ALI	ALI	NNP
cord-012045-1cqqj84n	20	7	/	/	SYM
cord-012045-1cqqj84n	20	8	ARDS	ARDS	NNP
cord-012045-1cqqj84n	20	9	patients	patient	NNS
cord-012045-1cqqj84n	20	10	are	be	VBP
cord-012045-1cqqj84n	20	11	linked	link	VBN
cord-012045-1cqqj84n	20	12	with	with	IN
cord-012045-1cqqj84n	20	13	viral	viral	JJ
cord-012045-1cqqj84n	20	14	and	and	CC
cord-012045-1cqqj84n	20	15	bacterial	bacterial	JJ
cord-012045-1cqqj84n	20	16	pneumonia	pneumonia	NN
cord-012045-1cqqj84n	20	17	.	.	.
cord-012045-1cqqj84n	21	1	The	the	DT
cord-012045-1cqqj84n	21	2	outbreak	outbreak	NN
cord-012045-1cqqj84n	21	3	of	of	IN
cord-012045-1cqqj84n	21	4	severe	severe	JJ
cord-012045-1cqqj84n	21	5	acute	acute	JJ
cord-012045-1cqqj84n	21	6	respiratory	respiratory	JJ
cord-012045-1cqqj84n	21	7	syndrome	syndrome	NN
cord-012045-1cqqj84n	21	8	coronavirus	coronavirus	NN
cord-012045-1cqqj84n	21	9	2	2	CD
cord-012045-1cqqj84n	21	10	(	(	-LRB-
cord-012045-1cqqj84n	21	11	SARS	SARS	NNP
cord-012045-1cqqj84n	21	12	-	-	HYPH
cord-012045-1cqqj84n	21	13	CoV-2	CoV-2	NNP
cord-012045-1cqqj84n	21	14	)	)	-RRB-
cord-012045-1cqqj84n	21	15	,	,	,
cord-012045-1cqqj84n	21	16	which	which	WDT
cord-012045-1cqqj84n	21	17	causes	cause	VBZ
cord-012045-1cqqj84n	21	18	coronavirus	coronavirus	NN
cord-012045-1cqqj84n	21	19	disease	disease	NN
cord-012045-1cqqj84n	21	20	2019	2019	CD
cord-012045-1cqqj84n	21	21	(	(	-LRB-
cord-012045-1cqqj84n	21	22	COVID-	COVID-	NNP
cord-012045-1cqqj84n	21	23	19	19	CD
cord-012045-1cqqj84n	21	24	)	)	-RRB-
cord-012045-1cqqj84n	21	25	,	,	,
cord-012045-1cqqj84n	21	26	has	have	VBZ
cord-012045-1cqqj84n	21	27	become	become	VBN
cord-012045-1cqqj84n	21	28	a	a	DT
cord-012045-1cqqj84n	21	29	pandemic	pandemic	NN
cord-012045-1cqqj84n	21	30	disease	disease	NN
cord-012045-1cqqj84n	21	31	.	.	.
cord-012045-1cqqj84n	22	1	By	by	IN
cord-012045-1cqqj84n	22	2	now	now	RB
cord-012045-1cqqj84n	22	3	,	,	,
cord-012045-1cqqj84n	22	4	millions	million	NNS
cord-012045-1cqqj84n	22	5	of	of	IN
cord-012045-1cqqj84n	22	6	people	people	NNS
cord-012045-1cqqj84n	22	7	have	have	VBP
cord-012045-1cqqj84n	22	8	suffered	suffer	VBN
cord-012045-1cqqj84n	22	9	from	from	IN
cord-012045-1cqqj84n	22	10	this	this	DT
cord-012045-1cqqj84n	22	11	disease	disease	NN
cord-012045-1cqqj84n	22	12	with	with	IN
cord-012045-1cqqj84n	22	13	hundreds	hundred	NNS
cord-012045-1cqqj84n	22	14	of	of	IN
cord-012045-1cqqj84n	22	15	thousands	thousand	NNS
cord-012045-1cqqj84n	22	16	of	of	IN
cord-012045-1cqqj84n	22	17	deaths	death	NNS
cord-012045-1cqqj84n	22	18	in	in	IN
cord-012045-1cqqj84n	22	19	almost	almost	RB
cord-012045-1cqqj84n	22	20	all	all	DT
cord-012045-1cqqj84n	22	21	countries	country	NNS
cord-012045-1cqqj84n	22	22	all	all	RB
cord-012045-1cqqj84n	22	23	over	over	IN
cord-012045-1cqqj84n	22	24	the	the	DT
cord-012045-1cqqj84n	22	25	world	world	NN
cord-012045-1cqqj84n	22	26	because	because	IN
cord-012045-1cqqj84n	22	27	of	of	IN
cord-012045-1cqqj84n	22	28	the	the	DT
cord-012045-1cqqj84n	22	29	pandemic	pandemic	NN
cord-012045-1cqqj84n	22	30	,	,	,
cord-012045-1cqqj84n	22	31	and	and	CC
cord-012045-1cqqj84n	22	32	the	the	DT
cord-012045-1cqqj84n	22	33	numbers	number	NNS
cord-012045-1cqqj84n	22	34	of	of	IN
cord-012045-1cqqj84n	22	35	the	the	DT
cord-012045-1cqqj84n	22	36	diagnosed	diagnose	VBN
cord-012045-1cqqj84n	22	37	patients	patient	NNS
cord-012045-1cqqj84n	22	38	and	and	CC
cord-012045-1cqqj84n	22	39	the	the	DT
cord-012045-1cqqj84n	22	40	deaths	death	NNS
cord-012045-1cqqj84n	22	41	due	due	JJ
cord-012045-1cqqj84n	22	42	to	to	IN
cord-012045-1cqqj84n	22	43	this	this	DT
cord-012045-1cqqj84n	22	44	disease	disease	NN
cord-012045-1cqqj84n	22	45	are	be	VBP
cord-012045-1cqqj84n	22	46	climbing	climb	VBG
cord-012045-1cqqj84n	22	47	each	each	DT
cord-012045-1cqqj84n	22	48	day	day	NN
cord-012045-1cqqj84n	22	49	(	(	-LRB-
cord-012045-1cqqj84n	22	50	https://coronavirus.jhu.edu/map	https://coronavirus.jhu.edu/map	NN
cord-012045-1cqqj84n	22	51	)	)	-RRB-
cord-012045-1cqqj84n	22	52	.	.	.
cord-012045-1cqqj84n	23	1	For	for	IN
cord-012045-1cqqj84n	23	2	severe	severe	JJ
cord-012045-1cqqj84n	23	3	COVID-19	covid-19	JJ
cord-012045-1cqqj84n	23	4	patients	patient	NNS
cord-012045-1cqqj84n	23	5	,	,	,
cord-012045-1cqqj84n	23	6	ALI	ALI	NNP
cord-012045-1cqqj84n	23	7	/	/	SYM
cord-012045-1cqqj84n	23	8	ARDS	ARDS	NNP
cord-012045-1cqqj84n	23	9	represent	represent	VBP
cord-012045-1cqqj84n	23	10	one	one	CD
cord-012045-1cqqj84n	23	11	of	of	IN
cord-012045-1cqqj84n	23	12	the	the	DT
cord-012045-1cqqj84n	23	13	major	major	JJ
cord-012045-1cqqj84n	23	14	pathological	pathological	JJ
cord-012045-1cqqj84n	23	15	changes	change	NNS
cord-012045-1cqqj84n	23	16	;	;	:
cord-012045-1cqqj84n	23	17	phenotypes	phenotype	NNS
cord-012045-1cqqj84n	23	18	include	include	VBP
cord-012045-1cqqj84n	23	19	inflammatory	inflammatory	JJ
cord-012045-1cqqj84n	23	20	infiltration	infiltration	NN
cord-012045-1cqqj84n	23	21	and	and	CC
cord-012045-1cqqj84n	23	22	inflammatory	inflammatory	JJ
cord-012045-1cqqj84n	23	23	storm	storm	NN
cord-012045-1cqqj84n	23	24	,	,	,
cord-012045-1cqqj84n	23	25	alveolar	alveolar	JJ
cord-012045-1cqqj84n	23	26	epithelial	epithelial	JJ
cord-012045-1cqqj84n	23	27	-	-	HYPH
cord-012045-1cqqj84n	23	28	capillary	capillary	JJ
cord-012045-1cqqj84n	23	29	damage	damage	NN
cord-012045-1cqqj84n	23	30	,	,	,
cord-012045-1cqqj84n	23	31	lung	lung	NN
cord-012045-1cqqj84n	23	32	embolism	embolism	NN
cord-012045-1cqqj84n	23	33	and	and	CC
cord-012045-1cqqj84n	23	34	hemorrhage	hemorrhage	NN
cord-012045-1cqqj84n	23	35	,	,	,
cord-012045-1cqqj84n	23	36	hypoxia	hypoxia	NN
cord-012045-1cqqj84n	23	37	,	,	,
cord-012045-1cqqj84n	23	38	and	and	CC
cord-012045-1cqqj84n	23	39	poor	poor	JJ
cord-012045-1cqqj84n	23	40	prognosis	prognosis	NN
cord-012045-1cqqj84n	23	41	with	with	IN
cord-012045-1cqqj84n	23	42	high	high	JJ
cord-012045-1cqqj84n	23	43	mortality	mortality	NN
cord-012045-1cqqj84n	23	44	.	.	.
cord-012045-1cqqj84n	24	1	The	the	DT
cord-012045-1cqqj84n	24	2	pathobiology	pathobiology	NN
cord-012045-1cqqj84n	24	3	of	of	IN
cord-012045-1cqqj84n	24	4	the	the	DT
cord-012045-1cqqj84n	24	5	disease	disease	NN
cord-012045-1cqqj84n	24	6	is	be	VBZ
cord-012045-1cqqj84n	24	7	incompletely	incompletely	RB
cord-012045-1cqqj84n	24	8	understood	understand	VBN
cord-012045-1cqqj84n	24	9	[	[	-LRB-
cord-012045-1cqqj84n	24	10	1	1	CD
cord-012045-1cqqj84n	24	11	,	,	,
cord-012045-1cqqj84n	24	12	[	[	-LRB-
cord-012045-1cqqj84n	24	13	6	6	CD
cord-012045-1cqqj84n	24	14	]	]	-RRB-
cord-012045-1cqqj84n	24	15	[	[	-LRB-
cord-012045-1cqqj84n	24	16	7	7	CD
cord-012045-1cqqj84n	24	17	]	]	-RRB-
cord-012045-1cqqj84n	25	1	[	[	-LRB-
cord-012045-1cqqj84n	25	2	8	8	CD
cord-012045-1cqqj84n	25	3	]	]	-RRB-
cord-012045-1cqqj84n	25	4	.	.	.
cord-012045-1cqqj84n	26	1	Furthermore	furthermore	RB
cord-012045-1cqqj84n	26	2	,	,	,
cord-012045-1cqqj84n	26	3	no	no	DT
cord-012045-1cqqj84n	26	4	specific	specific	JJ
cord-012045-1cqqj84n	26	5	effective	effective	JJ
cord-012045-1cqqj84n	26	6	therapeutic	therapeutic	JJ
cord-012045-1cqqj84n	26	7	method	method	NN
cord-012045-1cqqj84n	26	8	has	have	VBZ
cord-012045-1cqqj84n	26	9	been	be	VBN
cord-012045-1cqqj84n	26	10	developed	develop	VBN
cord-012045-1cqqj84n	26	11	to	to	TO
cord-012045-1cqqj84n	26	12	treat	treat	VB
cord-012045-1cqqj84n	26	13	the	the	DT
cord-012045-1cqqj84n	26	14	illness	illness	NN
cord-012045-1cqqj84n	26	15	.	.	.
cord-012045-1cqqj84n	27	1	Thus	thus	RB
cord-012045-1cqqj84n	27	2	,	,	,
cord-012045-1cqqj84n	27	3	understanding	understand	VBG
cord-012045-1cqqj84n	27	4	the	the	DT
cord-012045-1cqqj84n	27	5	molecular	molecular	JJ
cord-012045-1cqqj84n	27	6	mechanisms	mechanism	NNS
cord-012045-1cqqj84n	27	7	of	of	IN
cord-012045-1cqqj84n	27	8	ALI	ALI	NNP
cord-012045-1cqqj84n	27	9	/	/	SYM
cord-012045-1cqqj84n	27	10	ARDS	ARDS	NNP
cord-012045-1cqqj84n	27	11	is	be	VBZ
cord-012045-1cqqj84n	27	12	of	of	IN
cord-012045-1cqqj84n	27	13	particular	particular	RB
cord-012045-1cqqj84n	27	14	important	important	JJ
cord-012045-1cqqj84n	27	15	in	in	IN
cord-012045-1cqqj84n	27	16	developing	develop	VBG
cord-012045-1cqqj84n	27	17	effective	effective	JJ
cord-012045-1cqqj84n	27	18	remedies	remedy	NNS
cord-012045-1cqqj84n	27	19	against	against	IN
cord-012045-1cqqj84n	27	20	the	the	DT
cord-012045-1cqqj84n	27	21	illness	illness	NN
cord-012045-1cqqj84n	27	22	.	.	.
cord-012045-1cqqj84n	28	1	Overwhelmed	overwhelmed	JJ
cord-012045-1cqqj84n	28	2	immune	immune	JJ
cord-012045-1cqqj84n	28	3	responses	response	NNS
cord-012045-1cqqj84n	28	4	are	be	VBP
cord-012045-1cqqj84n	28	5	believed	believe	VBN
cord-012045-1cqqj84n	28	6	to	to	TO
cord-012045-1cqqj84n	28	7	be	be	VB
cord-012045-1cqqj84n	28	8	a	a	DT
cord-012045-1cqqj84n	28	9	major	major	JJ
cord-012045-1cqqj84n	28	10	contributing	contribute	VBG
cord-012045-1cqqj84n	28	11	factor	factor	NN
cord-012045-1cqqj84n	28	12	in	in	IN
cord-012045-1cqqj84n	28	13	the	the	DT
cord-012045-1cqqj84n	28	14	pathogenesis	pathogenesis	NN
cord-012045-1cqqj84n	28	15	of	of	IN
cord-012045-1cqqj84n	28	16	ALI	ALI	NNP
cord-012045-1cqqj84n	28	17	/	/	SYM
cord-012045-1cqqj84n	28	18	ARDS	ARDS	NNP
cord-012045-1cqqj84n	28	19	.	.	.
cord-012045-1cqqj84n	29	1	In	in	IN
cord-012045-1cqqj84n	29	2	the	the	DT
cord-012045-1cqqj84n	29	3	initial	initial	JJ
cord-012045-1cqqj84n	29	4	pulmonary	pulmonary	JJ
cord-012045-1cqqj84n	29	5	infection	infection	NN
cord-012045-1cqqj84n	29	6	,	,	,
cord-012045-1cqqj84n	29	7	invaded	invade	VBN
cord-012045-1cqqj84n	29	8	microbial	microbial	JJ
cord-012045-1cqqj84n	29	9	pathogens	pathogen	NNS
cord-012045-1cqqj84n	29	10	including	include	VBG
cord-012045-1cqqj84n	29	11	viruses	virus	NNS
cord-012045-1cqqj84n	29	12	and	and	CC
cord-012045-1cqqj84n	29	13	bacteria	bacteria	NNS
cord-012045-1cqqj84n	29	14	attract	attract	VBP
cord-012045-1cqqj84n	29	15	and	and	CC
cord-012045-1cqqj84n	29	16	activate	activate	VB
cord-012045-1cqqj84n	29	17	residential	residential	JJ
cord-012045-1cqqj84n	29	18	microphages	microphage	NNS
cord-012045-1cqqj84n	29	19	to	to	TO
cord-012045-1cqqj84n	29	20	release	release	VB
cord-012045-1cqqj84n	29	21	chemokines	chemokine	NNS
cord-012045-1cqqj84n	29	22	and	and	CC
cord-012045-1cqqj84n	29	23	cytokines	cytokine	NNS
cord-012045-1cqqj84n	29	24	,	,	,
cord-012045-1cqqj84n	29	25	along	along	IN
cord-012045-1cqqj84n	29	26	with	with	IN
cord-012045-1cqqj84n	29	27	infiltration	infiltration	NN
cord-012045-1cqqj84n	29	28	of	of	IN
cord-012045-1cqqj84n	29	29	leukocytes	leukocyte	NNS
cord-012045-1cqqj84n	29	30	,	,	,
cord-012045-1cqqj84n	29	31	particularly	particularly	RB
cord-012045-1cqqj84n	29	32	neutrophils	neutrophil	NNS
cord-012045-1cqqj84n	29	33	and	and	CC
cord-012045-1cqqj84n	29	34	lymphocytes	lymphocyte	NNS
cord-012045-1cqqj84n	29	35	,	,	,
cord-012045-1cqqj84n	29	36	into	into	IN
cord-012045-1cqqj84n	29	37	the	the	DT
cord-012045-1cqqj84n	29	38	alveolar	alveolar	JJ
cord-012045-1cqqj84n	29	39	sacs	sac	NNS
cord-012045-1cqqj84n	29	40	[	[	-LRB-
cord-012045-1cqqj84n	29	41	5	5	CD
cord-012045-1cqqj84n	29	42	,	,	,
cord-012045-1cqqj84n	29	43	9	9	CD
cord-012045-1cqqj84n	29	44	]	]	-RRB-
cord-012045-1cqqj84n	29	45	.	.	.
cord-012045-1cqqj84n	30	1	In	in	IN
cord-012045-1cqqj84n	30	2	ideal	ideal	JJ
cord-012045-1cqqj84n	30	3	scenarios	scenario	NNS
cord-012045-1cqqj84n	30	4	,	,	,
cord-012045-1cqqj84n	30	5	host	host	NN
cord-012045-1cqqj84n	30	6	immune	immune	JJ
cord-012045-1cqqj84n	30	7	responses	response	NNS
cord-012045-1cqqj84n	30	8	clear	clear	JJ
cord-012045-1cqqj84n	30	9	and	and	CC
cord-012045-1cqqj84n	30	10	exclude	exclude	VBP
cord-012045-1cqqj84n	30	11	the	the	DT
cord-012045-1cqqj84n	30	12	invaded	invade	VBN
cord-012045-1cqqj84n	30	13	pathogens	pathogen	NNS
cord-012045-1cqqj84n	30	14	and	and	CC
cord-012045-1cqqj84n	30	15	repair	repair	VB
cord-012045-1cqqj84n	30	16	the	the	DT
cord-012045-1cqqj84n	30	17	diseased	diseased	JJ
cord-012045-1cqqj84n	30	18	tissues	tissue	NNS
cord-012045-1cqqj84n	30	19	.	.	.
cord-012045-1cqqj84n	31	1	However	however	RB
cord-012045-1cqqj84n	31	2	,	,	,
cord-012045-1cqqj84n	31	3	host	host	NN
cord-012045-1cqqj84n	31	4	immune	immune	JJ
cord-012045-1cqqj84n	31	5	responses	response	NNS
cord-012045-1cqqj84n	31	6	may	may	MD
cord-012045-1cqqj84n	31	7	be	be	VB
cord-012045-1cqqj84n	31	8	unable	unable	JJ
cord-012045-1cqqj84n	31	9	to	to	TO
cord-012045-1cqqj84n	31	10	achieve	achieve	VB
cord-012045-1cqqj84n	31	11	this	this	DT
cord-012045-1cqqj84n	31	12	goal	goal	NN
cord-012045-1cqqj84n	31	13	due	due	IN
cord-012045-1cqqj84n	31	14	to	to	IN
cord-012045-1cqqj84n	31	15	the	the	DT
cord-012045-1cqqj84n	31	16	pathogenicity	pathogenicity	NN
cord-012045-1cqqj84n	31	17	of	of	IN
cord-012045-1cqqj84n	31	18	the	the	DT
cord-012045-1cqqj84n	31	19	microbe	microbe	NN
cord-012045-1cqqj84n	31	20	or	or	CC
cord-012045-1cqqj84n	31	21	the	the	DT
cord-012045-1cqqj84n	31	22	compromised	compromised	JJ
cord-012045-1cqqj84n	31	23	capacity	capacity	NN
cord-012045-1cqqj84n	31	24	of	of	IN
cord-012045-1cqqj84n	31	25	the	the	DT
cord-012045-1cqqj84n	31	26	host	host	NN
cord-012045-1cqqj84n	31	27	defense	defense	NN
cord-012045-1cqqj84n	31	28	,	,	,
cord-012045-1cqqj84n	31	29	such	such	JJ
cord-012045-1cqqj84n	31	30	as	as	IN
cord-012045-1cqqj84n	31	31	in	in	IN
cord-012045-1cqqj84n	31	32	patients	patient	NNS
cord-012045-1cqqj84n	31	33	with	with	IN
cord-012045-1cqqj84n	31	34	cancer	cancer	NN
cord-012045-1cqqj84n	31	35	,	,	,
cord-012045-1cqqj84n	31	36	organ	organ	NN
cord-012045-1cqqj84n	31	37	transplantation	transplantation	NN
cord-012045-1cqqj84n	31	38	,	,	,
cord-012045-1cqqj84n	31	39	diabetes	diabetes	NN
cord-012045-1cqqj84n	31	40	,	,	,
cord-012045-1cqqj84n	31	41	or	or	CC
cord-012045-1cqqj84n	31	42	HIV	HIV	NNP
cord-012045-1cqqj84n	31	43	infection	infection	NN
cord-012045-1cqqj84n	31	44	.	.	.
cord-012045-1cqqj84n	32	1	Higher	high	JJR
cord-012045-1cqqj84n	32	2	inflammatory	inflammatory	JJ
cord-012045-1cqqj84n	32	3	responses	response	NNS
cord-012045-1cqqj84n	32	4	may	may	MD
cord-012045-1cqqj84n	32	5	occur	occur	VB
cord-012045-1cqqj84n	32	6	in	in	IN
cord-012045-1cqqj84n	32	7	these	these	DT
cord-012045-1cqqj84n	32	8	cases	case	NNS
cord-012045-1cqqj84n	32	9	and	and	CC
cord-012045-1cqqj84n	32	10	an	an	DT
cord-012045-1cqqj84n	32	11	over	over	RB
cord-012045-1cqqj84n	32	12	-	-	HYPH
cord-012045-1cqqj84n	32	13	reacted	react	VBN
cord-012045-1cqqj84n	32	14	inflammatory	inflammatory	JJ
cord-012045-1cqqj84n	32	15	response	response	NN
cord-012045-1cqqj84n	32	16	eventually	eventually	RB
cord-012045-1cqqj84n	32	17	leads	lead	VBZ
cord-012045-1cqqj84n	32	18	to	to	IN
cord-012045-1cqqj84n	32	19	an	an	DT
cord-012045-1cqqj84n	32	20	overwhelmed	overwhelmed	JJ
cord-012045-1cqqj84n	32	21	inflammatory	inflammatory	JJ
cord-012045-1cqqj84n	32	22	response	response	NN
cord-012045-1cqqj84n	32	23	.	.	.
cord-012045-1cqqj84n	33	1	An	an	DT
cord-012045-1cqqj84n	33	2	overwhelmed	overwhelmed	JJ
cord-012045-1cqqj84n	33	3	inflammatory	inflammatory	JJ
cord-012045-1cqqj84n	33	4	response	response	NN
cord-012045-1cqqj84n	33	5	is	be	VBZ
cord-012045-1cqqj84n	33	6	increasingly	increasingly	RB
cord-012045-1cqqj84n	33	7	noticed	notice	VBN
cord-012045-1cqqj84n	33	8	as	as	IN
cord-012045-1cqqj84n	33	9	one	one	CD
cord-012045-1cqqj84n	33	10	of	of	IN
cord-012045-1cqqj84n	33	11	the	the	DT
cord-012045-1cqqj84n	33	12	key	key	JJ
cord-012045-1cqqj84n	33	13	contributors	contributor	NNS
cord-012045-1cqqj84n	33	14	to	to	IN
cord-012045-1cqqj84n	33	15	the	the	DT
cord-012045-1cqqj84n	33	16	poor	poor	JJ
cord-012045-1cqqj84n	33	17	prognosis	prognosis	NN
cord-012045-1cqqj84n	33	18	of	of	IN
cord-012045-1cqqj84n	33	19	ALI	ALI	NNP
cord-012045-1cqqj84n	33	20	/	/	SYM
cord-012045-1cqqj84n	33	21	ARDS	ARDS	NNP
cord-012045-1cqqj84n	33	22	.	.	.
cord-012045-1cqqj84n	34	1	A	a	DT
cord-012045-1cqqj84n	34	2	dysregulated	dysregulated	JJ
cord-012045-1cqqj84n	34	3	high	high	JJ
cord-012045-1cqqj84n	34	4	inflammatory	inflammatory	JJ
cord-012045-1cqqj84n	34	5	response	response	NN
cord-012045-1cqqj84n	34	6	,	,	,
cord-012045-1cqqj84n	34	7	also	also	RB
cord-012045-1cqqj84n	34	8	referred	refer	VBD
cord-012045-1cqqj84n	34	9	to	to	IN
cord-012045-1cqqj84n	34	10	as	as	IN
cord-012045-1cqqj84n	34	11	a	a	DT
cord-012045-1cqqj84n	34	12	"	"	``
cord-012045-1cqqj84n	34	13	cytokine	cytokine	NN
cord-012045-1cqqj84n	34	14	storm	storm	NN
cord-012045-1cqqj84n	34	15	"	"	''
cord-012045-1cqqj84n	34	16	,	,	,
cord-012045-1cqqj84n	34	17	increases	increase	VBZ
cord-012045-1cqqj84n	34	18	mortality	mortality	NN
cord-012045-1cqqj84n	34	19	in	in	IN
cord-012045-1cqqj84n	34	20	ALI	ALI	NNP
cord-012045-1cqqj84n	34	21	/	/	SYM
cord-012045-1cqqj84n	34	22	ARDS	ARDS	NNP
cord-012045-1cqqj84n	34	23	patients	patient	NNS
cord-012045-1cqqj84n	34	24	[	[	-LRB-
cord-012045-1cqqj84n	34	25	10	10	CD
cord-012045-1cqqj84n	34	26	,	,	,
cord-012045-1cqqj84n	34	27	11	11	CD
cord-012045-1cqqj84n	34	28	]	]	-RRB-
cord-012045-1cqqj84n	34	29	.	.	.
cord-012045-1cqqj84n	35	1	Along	along	IN
cord-012045-1cqqj84n	35	2	with	with	IN
cord-012045-1cqqj84n	35	3	the	the	DT
cord-012045-1cqqj84n	35	4	process	process	NN
cord-012045-1cqqj84n	35	5	of	of	IN
cord-012045-1cqqj84n	35	6	cytokine	cytokine	NN
cord-012045-1cqqj84n	35	7	storm	storm	NN
cord-012045-1cqqj84n	35	8	,	,	,
cord-012045-1cqqj84n	35	9	dysregulated	dysregulated	JJ
cord-012045-1cqqj84n	35	10	molecular	molecular	JJ
cord-012045-1cqqj84n	35	11	signaling	signaling	NN
cord-012045-1cqqj84n	35	12	may	may	MD
cord-012045-1cqqj84n	35	13	cause	cause	VB
cord-012045-1cqqj84n	35	14	deleterious	deleterious	JJ
cord-012045-1cqqj84n	35	15	damage	damage	NN
cord-012045-1cqqj84n	35	16	independent	independent	JJ
cord-012045-1cqqj84n	35	17	of	of	IN
cord-012045-1cqqj84n	35	18	microbial	microbial	JJ
cord-012045-1cqqj84n	35	19	pathogens	pathogen	NNS
cord-012045-1cqqj84n	35	20	that	that	WDT
cord-012045-1cqqj84n	35	21	increase	increase	VBP
cord-012045-1cqqj84n	35	22	mortality	mortality	NN
cord-012045-1cqqj84n	35	23	.	.	.
cord-012045-1cqqj84n	36	1	However	however	RB
cord-012045-1cqqj84n	36	2	,	,	,
cord-012045-1cqqj84n	36	3	a	a	DT
cord-012045-1cqqj84n	36	4	high	high	JJ
cord-012045-1cqqj84n	36	5	inflammatory	inflammatory	JJ
cord-012045-1cqqj84n	36	6	storm	storm	NN
cord-012045-1cqqj84n	36	7	turns	turn	VBZ
cord-012045-1cqqj84n	36	8	into	into	IN
cord-012045-1cqqj84n	36	9	low	low	JJ
cord-012045-1cqqj84n	36	10	inflammation	inflammation	NN
cord-012045-1cqqj84n	36	11	in	in	IN
cord-012045-1cqqj84n	36	12	the	the	DT
cord-012045-1cqqj84n	36	13	later	later	JJ
cord-012045-1cqqj84n	36	14	stage	stage	NN
cord-012045-1cqqj84n	36	15	due	due	JJ
cord-012045-1cqqj84n	36	16	to	to	IN
cord-012045-1cqqj84n	36	17	immune	immune	JJ
cord-012045-1cqqj84n	36	18	paralysis	paralysis	NN
cord-012045-1cqqj84n	36	19	that	that	WDT
cord-012045-1cqqj84n	36	20	may	may	MD
cord-012045-1cqqj84n	36	21	lead	lead	VB
cord-012045-1cqqj84n	36	22	to	to	IN
cord-012045-1cqqj84n	36	23	immunosuppression	immunosuppression	NN
cord-012045-1cqqj84n	36	24	,	,	,
cord-012045-1cqqj84n	36	25	which	which	WDT
cord-012045-1cqqj84n	36	26	contributes	contribute	VBZ
cord-012045-1cqqj84n	36	27	to	to	IN
cord-012045-1cqqj84n	36	28	secondary	secondary	JJ
cord-012045-1cqqj84n	36	29	infection	infection	NN
cord-012045-1cqqj84n	36	30	and	and	CC
cord-012045-1cqqj84n	36	31	worsens	worsen	VBZ
cord-012045-1cqqj84n	36	32	the	the	DT
cord-012045-1cqqj84n	36	33	prognosis	prognosis	NN
cord-012045-1cqqj84n	36	34	of	of	IN
cord-012045-1cqqj84n	36	35	the	the	DT
cord-012045-1cqqj84n	36	36	patients	patient	NNS
cord-012045-1cqqj84n	36	37	as	as	RB
cord-012045-1cqqj84n	36	38	well	well	RB
cord-012045-1cqqj84n	36	39	[	[	-LRB-
cord-012045-1cqqj84n	36	40	1	1	CD
cord-012045-1cqqj84n	36	41	]	]	-RRB-
cord-012045-1cqqj84n	36	42	.	.	.
cord-012045-1cqqj84n	37	1	In	in	IN
cord-012045-1cqqj84n	37	2	the	the	DT
cord-012045-1cqqj84n	37	3	meantime	meantime	NN
cord-012045-1cqqj84n	37	4	,	,	,
cord-012045-1cqqj84n	37	5	the	the	DT
cord-012045-1cqqj84n	37	6	invasion	invasion	NN
cord-012045-1cqqj84n	37	7	of	of	IN
cord-012045-1cqqj84n	37	8	microbial	microbial	JJ
cord-012045-1cqqj84n	37	9	pathogens	pathogen	NNS
cord-012045-1cqqj84n	37	10	causes	cause	VBZ
cord-012045-1cqqj84n	37	11	airway	airway	NN
cord-012045-1cqqj84n	37	12	epithelial	epithelial	JJ
cord-012045-1cqqj84n	37	13	and	and	CC
cord-012045-1cqqj84n	37	14	pulmonary	pulmonary	JJ
cord-012045-1cqqj84n	37	15	endothelial	endothelial	JJ
cord-012045-1cqqj84n	37	16	cell	cell	NN
cord-012045-1cqqj84n	37	17	death	death	NN
cord-012045-1cqqj84n	37	18	,	,	,
cord-012045-1cqqj84n	37	19	destroys	destroy	VBZ
cord-012045-1cqqj84n	37	20	alveolar	alveolar	NN
cord-012045-1cqqj84n	37	21	architecture	architecture	NN
cord-012045-1cqqj84n	37	22	,	,	,
cord-012045-1cqqj84n	37	23	and	and	CC
cord-012045-1cqqj84n	37	24	damages	damage	VBZ
cord-012045-1cqqj84n	37	25	the	the	DT
cord-012045-1cqqj84n	37	26	air	air	NN
cord-012045-1cqqj84n	37	27	-	-	HYPH
cord-012045-1cqqj84n	37	28	blood	blood	NN
cord-012045-1cqqj84n	37	29	barrier	barrier	NN
cord-012045-1cqqj84n	37	30	[	[	-LRB-
cord-012045-1cqqj84n	37	31	5	5	CD
cord-012045-1cqqj84n	37	32	,	,	,
cord-012045-1cqqj84n	37	33	12	12	CD
cord-012045-1cqqj84n	37	34	]	]	-RRB-
cord-012045-1cqqj84n	37	35	.	.	.
cord-012045-1cqqj84n	38	1	These	these	DT
cord-012045-1cqqj84n	38	2	pathological	pathological	JJ
cord-012045-1cqqj84n	38	3	changes	change	NNS
cord-012045-1cqqj84n	38	4	impair	impair	VBP
cord-012045-1cqqj84n	38	5	effective	effective	JJ
cord-012045-1cqqj84n	38	6	air	air	NN
cord-012045-1cqqj84n	38	7	-	-	HYPH
cord-012045-1cqqj84n	38	8	blood	blood	NN
cord-012045-1cqqj84n	38	9	exchange	exchange	NN
cord-012045-1cqqj84n	38	10	,	,	,
cord-012045-1cqqj84n	38	11	which	which	WDT
cord-012045-1cqqj84n	38	12	results	result	VBZ
cord-012045-1cqqj84n	38	13	in	in	IN
cord-012045-1cqqj84n	38	14	edema	edema	NN
cord-012045-1cqqj84n	38	15	and	and	CC
cord-012045-1cqqj84n	38	16	hypoxemia	hypoxemia	NN
cord-012045-1cqqj84n	38	17	.	.	.
cord-012045-1cqqj84n	39	1	Clinically	clinically	RB
cord-012045-1cqqj84n	39	2	,	,	,
cord-012045-1cqqj84n	39	3	hypoxemia	hypoxemia	NN
cord-012045-1cqqj84n	39	4	in	in	IN
cord-012045-1cqqj84n	39	5	patients	patient	NNS
cord-012045-1cqqj84n	39	6	with	with	IN
cord-012045-1cqqj84n	39	7	ARDS	ARDS	NNP
cord-012045-1cqqj84n	39	8	is	be	VBZ
cord-012045-1cqqj84n	39	9	caused	cause	VBN
cord-012045-1cqqj84n	39	10	by	by	IN
cord-012045-1cqqj84n	39	11	ventilation	ventilation	NN
cord-012045-1cqqj84n	39	12	-	-	HYPH
cord-012045-1cqqj84n	39	13	to	to	IN
cord-012045-1cqqj84n	39	14	-	-	HYPH
cord-012045-1cqqj84n	39	15	perfusion	perfusion	NN
cord-012045-1cqqj84n	39	16	mismatch	mismatch	NN
cord-012045-1cqqj84n	39	17	,	,	,
cord-012045-1cqqj84n	39	18	as	as	RB
cord-012045-1cqqj84n	39	19	well	well	RB
cord-012045-1cqqj84n	39	20	as	as	IN
cord-012045-1cqqj84n	39	21	right	right	NN
cord-012045-1cqqj84n	39	22	-	-	HYPH
cord-012045-1cqqj84n	39	23	to	to	IN
cord-012045-1cqqj84n	39	24	-	-	HYPH
cord-012045-1cqqj84n	39	25	left	leave	VBN
cord-012045-1cqqj84n	39	26	intrapulmonary	intrapulmonary	JJ
cord-012045-1cqqj84n	39	27	shunting	shunt	VBG
cord-012045-1cqqj84n	39	28	[	[	-LRB-
cord-012045-1cqqj84n	39	29	4	4	CD
cord-012045-1cqqj84n	39	30	]	]	-RRB-
cord-012045-1cqqj84n	39	31	.	.	.
cord-012045-1cqqj84n	40	1	In	in	IN
cord-012045-1cqqj84n	40	2	addition	addition	NN
cord-012045-1cqqj84n	40	3	,	,	,
cord-012045-1cqqj84n	40	4	impaired	impaired	JJ
cord-012045-1cqqj84n	40	5	excretion	excretion	NN
cord-012045-1cqqj84n	40	6	of	of	IN
cord-012045-1cqqj84n	40	7	carbon	carbon	NN
cord-012045-1cqqj84n	40	8	dioxide	dioxide	NN
cord-012045-1cqqj84n	40	9	is	be	VBZ
cord-012045-1cqqj84n	40	10	a	a	DT
cord-012045-1cqqj84n	40	11	major	major	JJ
cord-012045-1cqqj84n	40	12	component	component	NN
cord-012045-1cqqj84n	40	13	of	of	IN
cord-012045-1cqqj84n	40	14	respiratory	respiratory	JJ
cord-012045-1cqqj84n	40	15	failure	failure	NN
cord-012045-1cqqj84n	40	16	,	,	,
cord-012045-1cqqj84n	40	17	resulting	result	VBG
cord-012045-1cqqj84n	40	18	in	in	IN
cord-012045-1cqqj84n	40	19	elevated	elevated	JJ
cord-012045-1cqqj84n	40	20	minute	minute	NN
cord-012045-1cqqj84n	40	21	ventilation	ventilation	NN
cord-012045-1cqqj84n	40	22	that	that	WDT
cord-012045-1cqqj84n	40	23	is	be	VBZ
cord-012045-1cqqj84n	40	24	associated	associate	VBN
cord-012045-1cqqj84n	40	25	with	with	IN
cord-012045-1cqqj84n	40	26	an	an	DT
cord-012045-1cqqj84n	40	27	increase	increase	NN
cord-012045-1cqqj84n	40	28	in	in	IN
cord-012045-1cqqj84n	40	29	pulmonary	pulmonary	JJ
cord-012045-1cqqj84n	40	30	dead	dead	JJ
cord-012045-1cqqj84n	40	31	space	space	NN
cord-012045-1cqqj84n	40	32	(	(	-LRB-
cord-012045-1cqqj84n	40	33	that	that	RB
cord-012045-1cqqj84n	40	34	is	is	RB
cord-012045-1cqqj84n	40	35	,	,	,
cord-012045-1cqqj84n	40	36	the	the	DT
cord-012045-1cqqj84n	40	37	volume	volume	NN
cord-012045-1cqqj84n	40	38	of	of	IN
cord-012045-1cqqj84n	40	39	a	a	DT
cord-012045-1cqqj84n	40	40	breath	breath	NN
cord-012045-1cqqj84n	40	41	that	that	WDT
cord-012045-1cqqj84n	40	42	does	do	VBZ
cord-012045-1cqqj84n	40	43	not	not	RB
cord-012045-1cqqj84n	40	44	participate	participate	VB
cord-012045-1cqqj84n	40	45	in	in	IN
cord-012045-1cqqj84n	40	46	carbon	carbon	NN
cord-012045-1cqqj84n	40	47	dioxide	dioxide	NN
cord-012045-1cqqj84n	40	48	excretion	excretion	NN
cord-012045-1cqqj84n	40	49	)	)	-RRB-
cord-012045-1cqqj84n	40	50	.	.	.
cord-012045-1cqqj84n	41	1	Elevation	elevation	NN
cord-012045-1cqqj84n	41	2	of	of	IN
cord-012045-1cqqj84n	41	3	pulmonary	pulmonary	JJ
cord-012045-1cqqj84n	41	4	dead	dead	JJ
cord-012045-1cqqj84n	41	5	space	space	NN
cord-012045-1cqqj84n	41	6	and	and	CC
cord-012045-1cqqj84n	41	7	a	a	DT
cord-012045-1cqqj84n	41	8	decrease	decrease	NN
cord-012045-1cqqj84n	41	9	in	in	IN
cord-012045-1cqqj84n	41	10	respiratory	respiratory	JJ
cord-012045-1cqqj84n	41	11	compliance	compliance	NN
cord-012045-1cqqj84n	41	12	are	be	VBP
cord-012045-1cqqj84n	41	13	independent	independent	JJ
cord-012045-1cqqj84n	41	14	predictors	predictor	NNS
cord-012045-1cqqj84n	41	15	of	of	IN
cord-012045-1cqqj84n	41	16	mortality	mortality	NN
cord-012045-1cqqj84n	41	17	in	in	IN
cord-012045-1cqqj84n	41	18	ARDS	ARDS	NNP
cord-012045-1cqqj84n	41	19	[	[	-LRB-
cord-012045-1cqqj84n	41	20	13	13	CD
cord-012045-1cqqj84n	41	21	]	]	-RRB-
cord-012045-1cqqj84n	41	22	.	.	.
cord-012045-1cqqj84n	42	1	The	the	DT
cord-012045-1cqqj84n	42	2	pathophysiological	pathophysiological	JJ
cord-012045-1cqqj84n	42	3	mechanisms	mechanism	NNS
cord-012045-1cqqj84n	42	4	of	of	IN
cord-012045-1cqqj84n	42	5	ALI	ALI	NNP
cord-012045-1cqqj84n	42	6	/	/	SYM
cord-012045-1cqqj84n	42	7	ARDS	ARDS	NNP
cord-012045-1cqqj84n	42	8	are	be	VBP
cord-012045-1cqqj84n	42	9	yet	yet	RB
cord-012045-1cqqj84n	42	10	to	to	TO
cord-012045-1cqqj84n	42	11	be	be	VB
cord-012045-1cqqj84n	42	12	fully	fully	RB
cord-012045-1cqqj84n	42	13	understood	understand	VBN
cord-012045-1cqqj84n	42	14	.	.	.
cord-012045-1cqqj84n	43	1	A	a	DT
cord-012045-1cqqj84n	43	2	large	large	JJ
cord-012045-1cqqj84n	43	3	number	number	NN
cord-012045-1cqqj84n	43	4	of	of	IN
cord-012045-1cqqj84n	43	5	signal	signal	NN
cord-012045-1cqqj84n	43	6	transduction	transduction	NN
cord-012045-1cqqj84n	43	7	pathways	pathway	NNS
cord-012045-1cqqj84n	43	8	have	have	VBP
cord-012045-1cqqj84n	43	9	been	be	VBN
cord-012045-1cqqj84n	43	10	revealed	reveal	VBN
cord-012045-1cqqj84n	43	11	to	to	TO
cord-012045-1cqqj84n	43	12	be	be	VB
cord-012045-1cqqj84n	43	13	involved	involve	VBN
cord-012045-1cqqj84n	43	14	in	in	IN
cord-012045-1cqqj84n	43	15	this	this	DT
cord-012045-1cqqj84n	43	16	process	process	NN
cord-012045-1cqqj84n	43	17	.	.	.
cord-012045-1cqqj84n	44	1	Signal	signal	NN
cord-012045-1cqqj84n	44	2	transductions	transduction	NNS
cord-012045-1cqqj84n	44	3	in	in	IN
cord-012045-1cqqj84n	44	4	control	control	NN
cord-012045-1cqqj84n	44	5	of	of	IN
cord-012045-1cqqj84n	44	6	protein	protein	NN
cord-012045-1cqqj84n	44	7	stability	stability	NN
cord-012045-1cqqj84n	44	8	and	and	CC
cord-012045-1cqqj84n	44	9	availability	availability	NN
cord-012045-1cqqj84n	44	10	,	,	,
cord-012045-1cqqj84n	44	11	including	include	VBG
cord-012045-1cqqj84n	44	12	protein	protein	NN
cord-012045-1cqqj84n	44	13	ubiquitination	ubiquitination	NN
cord-012045-1cqqj84n	44	14	and	and	CC
cord-012045-1cqqj84n	44	15	degradation	degradation	NN
cord-012045-1cqqj84n	44	16	,	,	,
cord-012045-1cqqj84n	44	17	are	be	VBP
cord-012045-1cqqj84n	44	18	typical	typical	JJ
cord-012045-1cqqj84n	44	19	among	among	IN
cord-012045-1cqqj84n	44	20	the	the	DT
cord-012045-1cqqj84n	44	21	pathways	pathway	NNS
cord-012045-1cqqj84n	44	22	.	.	.
cord-012045-1cqqj84n	45	1	Several	several	JJ
cord-012045-1cqqj84n	45	2	review	review	NN
cord-012045-1cqqj84n	45	3	articles	article	NNS
cord-012045-1cqqj84n	45	4	have	have	VBP
cord-012045-1cqqj84n	45	5	introduced	introduce	VBN
cord-012045-1cqqj84n	45	6	the	the	DT
cord-012045-1cqqj84n	45	7	role	role	NN
cord-012045-1cqqj84n	45	8	of	of	IN
cord-012045-1cqqj84n	45	9	ubiquitination	ubiquitination	NN
cord-012045-1cqqj84n	45	10	and	and	CC
cord-012045-1cqqj84n	45	11	proteolysis	proteolysis	NN
cord-012045-1cqqj84n	45	12	in	in	IN
cord-012045-1cqqj84n	45	13	lung	lung	NN
cord-012045-1cqqj84n	45	14	diseases	disease	NNS
cord-012045-1cqqj84n	45	15	[	[	-LRB-
cord-012045-1cqqj84n	45	16	14	14	CD
cord-012045-1cqqj84n	45	17	]	]	-RRB-
cord-012045-1cqqj84n	45	18	[	[	-LRB-
cord-012045-1cqqj84n	45	19	15	15	CD
cord-012045-1cqqj84n	45	20	]	]	-RRB-
cord-012045-1cqqj84n	45	21	[	[	-LRB-
cord-012045-1cqqj84n	45	22	16	16	CD
cord-012045-1cqqj84n	45	23	]	]	-RRB-
cord-012045-1cqqj84n	45	24	.	.	.
cord-012045-1cqqj84n	46	1	In	in	IN
cord-012045-1cqqj84n	46	2	this	this	DT
cord-012045-1cqqj84n	46	3	review	review	NN
cord-012045-1cqqj84n	46	4	,	,	,
cord-012045-1cqqj84n	46	5	we	-PRON-	PRP
cord-012045-1cqqj84n	46	6	summarize	summarize	VBP
cord-012045-1cqqj84n	46	7	recent	recent	JJ
cord-012045-1cqqj84n	46	8	findings	finding	NNS
cord-012045-1cqqj84n	46	9	regarding	regard	VBG
cord-012045-1cqqj84n	46	10	the	the	DT
cord-012045-1cqqj84n	46	11	importance	importance	NN
cord-012045-1cqqj84n	46	12	of	of	IN
cord-012045-1cqqj84n	46	13	deubiquitination	deubiquitination	NN
cord-012045-1cqqj84n	46	14	and	and	CC
cord-012045-1cqqj84n	46	15	DUBs	dub	NNS
cord-012045-1cqqj84n	46	16	in	in	IN
cord-012045-1cqqj84n	46	17	regulation	regulation	NN
cord-012045-1cqqj84n	46	18	of	of	IN
cord-012045-1cqqj84n	46	19	inflammation	inflammation	NN
cord-012045-1cqqj84n	46	20	and	and	CC
cord-012045-1cqqj84n	46	21	related	related	JJ
cord-012045-1cqqj84n	46	22	pathologies	pathology	NNS
cord-012045-1cqqj84n	46	23	and	and	CC
cord-012045-1cqqj84n	46	24	highlight	highlight	VB
cord-012045-1cqqj84n	46	25	the	the	DT
cord-012045-1cqqj84n	46	26	role	role	NN
cord-012045-1cqqj84n	46	27	of	of	IN
cord-012045-1cqqj84n	46	28	DUBs	dub	NNS
cord-012045-1cqqj84n	46	29	in	in	IN
cord-012045-1cqqj84n	46	30	ALI	ALI	NNP
cord-012045-1cqqj84n	46	31	/	/	SYM
cord-012045-1cqqj84n	46	32	ARDS	ARDS	NNP
cord-012045-1cqqj84n	46	33	.	.	.
cord-012045-1cqqj84n	47	1	Proteins	protein	NNS
cord-012045-1cqqj84n	47	2	dynamically	dynamically	RB
cord-012045-1cqqj84n	47	3	exert	exert	VBP
cord-012045-1cqqj84n	47	4	their	-PRON-	PRP$
cord-012045-1cqqj84n	47	5	diversified	diversify	VBN
cord-012045-1cqqj84n	47	6	functions	function	NNS
cord-012045-1cqqj84n	47	7	in	in	IN
cord-012045-1cqqj84n	47	8	life	life	NN
cord-012045-1cqqj84n	47	9	processes	process	NNS
cord-012045-1cqqj84n	47	10	in	in	IN
cord-012045-1cqqj84n	47	11	response	response	NN
cord-012045-1cqqj84n	47	12	to	to	IN
cord-012045-1cqqj84n	47	13	different	different	JJ
cord-012045-1cqqj84n	47	14	pathophysiological	pathophysiological	JJ
cord-012045-1cqqj84n	47	15	settings	setting	NNS
cord-012045-1cqqj84n	47	16	.	.	.
cord-012045-1cqqj84n	48	1	In	in	IN
cord-012045-1cqqj84n	48	2	concert	concert	NN
cord-012045-1cqqj84n	48	3	with	with	IN
cord-012045-1cqqj84n	48	4	gene	gene	NN
cord-012045-1cqqj84n	48	5	transcription	transcription	NN
cord-012045-1cqqj84n	48	6	,	,	,
cord-012045-1cqqj84n	48	7	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	48	8	proteasome	proteasome	VBN
cord-012045-1cqqj84n	48	9	degradation	degradation	NN
cord-012045-1cqqj84n	48	10	governs	govern	VBZ
cord-012045-1cqqj84n	48	11	the	the	DT
cord-012045-1cqqj84n	48	12	abundance	abundance	NN
cord-012045-1cqqj84n	48	13	and	and	CC
cord-012045-1cqqj84n	48	14	availability	availability	NN
cord-012045-1cqqj84n	48	15	of	of	IN
cord-012045-1cqqj84n	48	16	the	the	DT
cord-012045-1cqqj84n	48	17	protein	protein	NN
cord-012045-1cqqj84n	48	18	in	in	IN
cord-012045-1cqqj84n	48	19	the	the	DT
cord-012045-1cqqj84n	48	20	cell	cell	NN
cord-012045-1cqqj84n	48	21	.	.	.
cord-012045-1cqqj84n	49	1	Most	Most	JJS
cord-012045-1cqqj84n	49	2	of	of	IN
cord-012045-1cqqj84n	49	3	the	the	DT
cord-012045-1cqqj84n	49	4	proteins	protein	NNS
cord-012045-1cqqj84n	49	5	modified	modify	VBN
cord-012045-1cqqj84n	49	6	by	by	IN
cord-012045-1cqqj84n	49	7	a	a	DT
cord-012045-1cqqj84n	49	8	post	post	JJ
cord-012045-1cqqj84n	49	9	translational	translational	JJ
cord-012045-1cqqj84n	49	10	modification	modification	NN
cord-012045-1cqqj84n	49	11	called	call	VBN
cord-012045-1cqqj84n	49	12	ubiquitination	ubiquitination	NN
cord-012045-1cqqj84n	49	13	are	be	VBP
cord-012045-1cqqj84n	49	14	deemed	deem	VBN
cord-012045-1cqqj84n	49	15	to	to	TO
cord-012045-1cqqj84n	49	16	be	be	VB
cord-012045-1cqqj84n	49	17	degraded	degrade	VBN
cord-012045-1cqqj84n	49	18	[	[	-LRB-
cord-012045-1cqqj84n	49	19	17	17	CD
cord-012045-1cqqj84n	49	20	,	,	,
cord-012045-1cqqj84n	49	21	18	18	CD
cord-012045-1cqqj84n	49	22	]	]	-RRB-
cord-012045-1cqqj84n	49	23	.	.	.
cord-012045-1cqqj84n	50	1	Ubiquitination	Ubiquitination	NNP
cord-012045-1cqqj84n	50	2	involves	involve	VBZ
cord-012045-1cqqj84n	50	3	the	the	DT
cord-012045-1cqqj84n	50	4	covalent	covalent	JJ
cord-012045-1cqqj84n	50	5	attachment	attachment	NN
cord-012045-1cqqj84n	50	6	of	of	IN
cord-012045-1cqqj84n	50	7	the	the	DT
cord-012045-1cqqj84n	50	8	small	small	JJ
cord-012045-1cqqj84n	50	9	conserved	conserved	JJ
cord-012045-1cqqj84n	50	10	protein	protein	NN
cord-012045-1cqqj84n	50	11	called	call	VBN
cord-012045-1cqqj84n	50	12	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	50	13	(	(	-LRB-
cord-012045-1cqqj84n	50	14	Ub	Ub	NNP
cord-012045-1cqqj84n	50	15	,	,	,
cord-012045-1cqqj84n	50	16	87	87	CD
cord-012045-1cqqj84n	50	17	amino	amino	NN
cord-012045-1cqqj84n	50	18	acids	acid	NNS
cord-012045-1cqqj84n	50	19	in	in	IN
cord-012045-1cqqj84n	50	20	length	length	NN
cord-012045-1cqqj84n	50	21	)	)	-RRB-
cord-012045-1cqqj84n	50	22	to	to	IN
cord-012045-1cqqj84n	50	23	a	a	DT
cord-012045-1cqqj84n	50	24	target	target	NN
cord-012045-1cqqj84n	50	25	protein	protein	NN
cord-012045-1cqqj84n	50	26	,	,	,
cord-012045-1cqqj84n	50	27	almost	almost	RB
cord-012045-1cqqj84n	50	28	exclusively	exclusively	RB
cord-012045-1cqqj84n	50	29	at	at	IN
cord-012045-1cqqj84n	50	30	a	a	DT
cord-012045-1cqqj84n	50	31	lysine	lysine	NN
cord-012045-1cqqj84n	50	32	residue	residue	NN
cord-012045-1cqqj84n	50	33	.	.	.
cord-012045-1cqqj84n	51	1	Ubiquitination	Ubiquitination	NNP
cord-012045-1cqqj84n	51	2	is	be	VBZ
cord-012045-1cqqj84n	51	3	an	an	DT
cord-012045-1cqqj84n	51	4	enzymatic	enzymatic	JJ
cord-012045-1cqqj84n	51	5	cascade	cascade	NN
cord-012045-1cqqj84n	51	6	that	that	WDT
cord-012045-1cqqj84n	51	7	requires	require	VBZ
cord-012045-1cqqj84n	51	8	the	the	DT
cord-012045-1cqqj84n	51	9	orchestrated	orchestrate	VBN
cord-012045-1cqqj84n	51	10	interplay	interplay	NN
cord-012045-1cqqj84n	51	11	of	of	IN
cord-012045-1cqqj84n	51	12	three	three	CD
cord-012045-1cqqj84n	51	13	different	different	JJ
cord-012045-1cqqj84n	51	14	enzymes	enzyme	NNS
cord-012045-1cqqj84n	51	15	(	(	-LRB-
cord-012045-1cqqj84n	51	16	Figure	figure	NN
cord-012045-1cqqj84n	51	17	1	1	CD
cord-012045-1cqqj84n	51	18	)	)	-RRB-
cord-012045-1cqqj84n	51	19	.	.	.
cord-012045-1cqqj84n	52	1	E1	E1	NNP
cord-012045-1cqqj84n	52	2	Ub	Ub	NNP
cord-012045-1cqqj84n	52	3	-	-	HYPH
cord-012045-1cqqj84n	52	4	activating	activate	VBG
cord-012045-1cqqj84n	52	5	enzymes	enzyme	NNS
cord-012045-1cqqj84n	52	6	bind	bind	VBP
cord-012045-1cqqj84n	52	7	to	to	IN
cord-012045-1cqqj84n	52	8	both	both	CC
cord-012045-1cqqj84n	52	9	ATP	ATP	NNP
cord-012045-1cqqj84n	52	10	and	and	CC
cord-012045-1cqqj84n	52	11	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	52	12	and	and	CC
cord-012045-1cqqj84n	52	13	expose	expose	VB
cord-012045-1cqqj84n	52	14	a	a	DT
cord-012045-1cqqj84n	52	15	cysteine	cysteine	NN
cord-012045-1cqqj84n	52	16	residue	residue	NN
cord-012045-1cqqj84n	52	17	,	,	,
cord-012045-1cqqj84n	52	18	the	the	DT
cord-012045-1cqqj84n	52	19	active	active	JJ
cord-012045-1cqqj84n	52	20	site	site	NN
cord-012045-1cqqj84n	52	21	of	of	IN
cord-012045-1cqqj84n	52	22	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	52	23	,	,	,
cord-012045-1cqqj84n	52	24	with	with	IN
cord-012045-1cqqj84n	52	25	the	the	DT
cord-012045-1cqqj84n	52	26	release	release	NN
cord-012045-1cqqj84n	52	27	of	of	IN
cord-012045-1cqqj84n	52	28	an	an	DT
cord-012045-1cqqj84n	52	29	AMP	amp	NN
cord-012045-1cqqj84n	52	30	.	.	.
cord-012045-1cqqj84n	53	1	E2	E2	NNP
cord-012045-1cqqj84n	53	2	Ub	Ub	NNP
cord-012045-1cqqj84n	53	3	-	-	HYPH
cord-012045-1cqqj84n	53	4	conjugating	conjugate	VBG
cord-012045-1cqqj84n	53	5	enzymes	enzyme	NNS
cord-012045-1cqqj84n	53	6	take	take	VBP
cord-012045-1cqqj84n	53	7	over	over	RP
cord-012045-1cqqj84n	53	8	activated	activate	VBN
cord-012045-1cqqj84n	53	9	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	53	10	from	from	IN
cord-012045-1cqqj84n	53	11	E1	e1	NN
cord-012045-1cqqj84n	53	12	enzymes	enzyme	NNS
cord-012045-1cqqj84n	53	13	and	and	CC
cord-012045-1cqqj84n	53	14	cooperate	cooperate	VBP
cord-012045-1cqqj84n	53	15	with	with	IN
cord-012045-1cqqj84n	53	16	E3	E3	NNP
cord-012045-1cqqj84n	53	17	Ub	Ub	NNP
cord-012045-1cqqj84n	53	18	-	-	HYPH
cord-012045-1cqqj84n	53	19	ligases	ligase	NNS
cord-012045-1cqqj84n	53	20	.	.	.
cord-012045-1cqqj84n	54	1	The	the	DT
cord-012045-1cqqj84n	54	2	E3	e3	NN
cord-012045-1cqqj84n	54	3	Ub	Ub	NNP
cord-012045-1cqqj84n	54	4	-	-	HYPH
cord-012045-1cqqj84n	54	5	ligases	ligase	NNS
cord-012045-1cqqj84n	54	6	interact	interact	VBP
cord-012045-1cqqj84n	54	7	with	with	IN
cord-012045-1cqqj84n	54	8	E2	E2	NNP
cord-012045-1cqqj84n	54	9	enzymes	enzyme	NNS
cord-012045-1cqqj84n	54	10	and	and	CC
cord-012045-1cqqj84n	54	11	recruit	recruit	VBP
cord-012045-1cqqj84n	54	12	protein	protein	NN
cord-012045-1cqqj84n	54	13	substrates	substrate	NNS
cord-012045-1cqqj84n	54	14	to	to	TO
cord-012045-1cqqj84n	54	15	initiate	initiate	VB
cord-012045-1cqqj84n	54	16	conjugation	conjugation	NN
cord-012045-1cqqj84n	54	17	of	of	IN
cord-012045-1cqqj84n	54	18	single	single	JJ
cord-012045-1cqqj84n	54	19	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	54	20	or	or	CC
cord-012045-1cqqj84n	54	21	polymeric	polymeric	JJ
cord-012045-1cqqj84n	54	22	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	54	23	chains	chain	NNS
cord-012045-1cqqj84n	54	24	to	to	IN
cord-012045-1cqqj84n	54	25	the	the	DT
cord-012045-1cqqj84n	54	26	protein	protein	NN
cord-012045-1cqqj84n	54	27	substrates	substrate	NNS
cord-012045-1cqqj84n	54	28	.	.	.
cord-012045-1cqqj84n	55	1	E3	E3	NNP
cord-012045-1cqqj84n	55	2	Ub	Ub	NNP
cord-012045-1cqqj84n	55	3	-	-	HYPH
cord-012045-1cqqj84n	55	4	ligases	ligase	NNS
cord-012045-1cqqj84n	55	5	recognize	recognize	VBP
cord-012045-1cqqj84n	55	6	the	the	DT
cord-012045-1cqqj84n	55	7	protein	protein	NN
cord-012045-1cqqj84n	55	8	substrates	substrate	NNS
cord-012045-1cqqj84n	55	9	and	and	CC
cord-012045-1cqqj84n	55	10	determine	determine	VB
cord-012045-1cqqj84n	55	11	the	the	DT
cord-012045-1cqqj84n	55	12	specificity	specificity	NN
cord-012045-1cqqj84n	55	13	of	of	IN
cord-012045-1cqqj84n	55	14	protein	protein	NN
cord-012045-1cqqj84n	55	15	substrates	substrate	NNS
cord-012045-1cqqj84n	55	16	[	[	-LRB-
cord-012045-1cqqj84n	55	17	19	19	CD
cord-012045-1cqqj84n	55	18	,	,	,
cord-012045-1cqqj84n	55	19	20	20	CD
cord-012045-1cqqj84n	55	20	]	]	-RRB-
cord-012045-1cqqj84n	55	21	.	.	.
cord-012045-1cqqj84n	56	1	In	in	IN
cord-012045-1cqqj84n	56	2	humans	human	NNS
cord-012045-1cqqj84n	56	3	,	,	,
cord-012045-1cqqj84n	56	4	there	there	EX
cord-012045-1cqqj84n	56	5	are	be	VBP
cord-012045-1cqqj84n	56	6	two	two	CD
cord-012045-1cqqj84n	56	7	E1	e1	NN
cord-012045-1cqqj84n	56	8	Ub	Ub	NNP
cord-012045-1cqqj84n	56	9	-	-	HYPH
cord-012045-1cqqj84n	56	10	activating	activate	VBG
cord-012045-1cqqj84n	56	11	enzymes	enzyme	NNS
cord-012045-1cqqj84n	56	12	,	,	,
cord-012045-1cqqj84n	56	13	14	14	CD
cord-012045-1cqqj84n	56	14	E2	E2	NNP
cord-012045-1cqqj84n	56	15	Ub	Ub	NNP
cord-012045-1cqqj84n	56	16	-	-	HYPH
cord-012045-1cqqj84n	56	17	conjugating	conjugate	VBG
cord-012045-1cqqj84n	56	18	enzymes	enzyme	NNS
cord-012045-1cqqj84n	56	19	,	,	,
cord-012045-1cqqj84n	56	20	and	and	CC
cord-012045-1cqqj84n	56	21	approximately	approximately	RB
cord-012045-1cqqj84n	56	22	1000	1000	CD
cord-012045-1cqqj84n	56	23	E3	E3	NNP
cord-012045-1cqqj84n	56	24	Ub	Ub	NNP
cord-012045-1cqqj84n	56	25	-	-	HYPH
cord-012045-1cqqj84n	56	26	ligases	ligase	NNS
cord-012045-1cqqj84n	56	27	[	[	-LRB-
cord-012045-1cqqj84n	56	28	21	21	CD
cord-012045-1cqqj84n	56	29	]	]	-RRB-
cord-012045-1cqqj84n	56	30	.	.	.
cord-012045-1cqqj84n	57	1	Protein	protein	NN
cord-012045-1cqqj84n	57	2	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	57	3	proteasomal	proteasomal	JJ
cord-012045-1cqqj84n	57	4	degradation	degradation	NN
cord-012045-1cqqj84n	57	5	and	and	CC
cord-012045-1cqqj84n	57	6	deubiquitination	deubiquitination	NN
cord-012045-1cqqj84n	57	7	.	.	.
cord-012045-1cqqj84n	58	1	A	a	DT
cord-012045-1cqqj84n	58	2	protein	protein	NN
cord-012045-1cqqj84n	58	3	destined	destine	VBN
cord-012045-1cqqj84n	58	4	for	for	IN
cord-012045-1cqqj84n	58	5	degradation	degradation	NN
cord-012045-1cqqj84n	58	6	unleashes	unleash	VBZ
cord-012045-1cqqj84n	58	7	a	a	DT
cord-012045-1cqqj84n	58	8	cascade	cascade	NN
cord-012045-1cqqj84n	58	9	of	of	IN
cord-012045-1cqqj84n	58	10	enzymatic	enzymatic	JJ
cord-012045-1cqqj84n	58	11	activity	activity	NN
cord-012045-1cqqj84n	58	12	involving	involve	VBG
cord-012045-1cqqj84n	58	13	ubiquitination	ubiquitination	NN
cord-012045-1cqqj84n	58	14	and	and	CC
cord-012045-1cqqj84n	58	15	proteasomal	proteasomal	JJ
cord-012045-1cqqj84n	58	16	degradation	degradation	NN
cord-012045-1cqqj84n	58	17	.	.	.
cord-012045-1cqqj84n	59	1	E1	E1	NNP
cord-012045-1cqqj84n	59	2	Ub	Ub	NNP
cord-012045-1cqqj84n	59	3	-	-	HYPH
cord-012045-1cqqj84n	59	4	activating	activate	VBG
cord-012045-1cqqj84n	59	5	enzymes	enzyme	NNS
cord-012045-1cqqj84n	59	6	activate	activate	VBP
cord-012045-1cqqj84n	59	7	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	59	8	and	and	CC
cord-012045-1cqqj84n	59	9	pass	pass	VB
cord-012045-1cqqj84n	59	10	the	the	DT
cord-012045-1cqqj84n	59	11	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	59	12	to	to	IN
cord-012045-1cqqj84n	59	13	E2-Ub	E2-Ub	NNP
cord-012045-1cqqj84n	59	14	-	-	HYPH
cord-012045-1cqqj84n	59	15	conjugating	conjugate	VBG
cord-012045-1cqqj84n	59	16	enzymes	enzyme	NNS
cord-012045-1cqqj84n	59	17	.	.	.
cord-012045-1cqqj84n	60	1	E3	E3	NNP
cord-012045-1cqqj84n	60	2	Ub	Ub	NNP
cord-012045-1cqqj84n	60	3	-	-	HYPH
cord-012045-1cqqj84n	60	4	ligases	ligase	NNS
cord-012045-1cqqj84n	60	5	recognize	recognize	VBP
cord-012045-1cqqj84n	60	6	the	the	DT
cord-012045-1cqqj84n	60	7	protein	protein	NN
cord-012045-1cqqj84n	60	8	substrates	substrate	NNS
cord-012045-1cqqj84n	60	9	and	and	CC
cord-012045-1cqqj84n	60	10	couple	couple	NN
cord-012045-1cqqj84n	60	11	E2-Ub	E2-Ub	NNS
cord-012045-1cqqj84n	60	12	-	-	HYPH
cord-012045-1cqqj84n	60	13	conjugating	conjugate	VBG
cord-012045-1cqqj84n	60	14	enzymes	enzyme	NNS
cord-012045-1cqqj84n	60	15	to	to	TO
cord-012045-1cqqj84n	60	16	covalently	covalently	RB
cord-012045-1cqqj84n	60	17	add	add	VB
cord-012045-1cqqj84n	60	18	the	the	DT
cord-012045-1cqqj84n	60	19	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	60	20	or	or	CC
cord-012045-1cqqj84n	60	21	ubiquitin	ubiquitin	JJ
cord-012045-1cqqj84n	60	22	moieties	moiety	NNS
cord-012045-1cqqj84n	60	23	to	to	IN
cord-012045-1cqqj84n	60	24	the	the	DT
cord-012045-1cqqj84n	60	25	protein	protein	NN
cord-012045-1cqqj84n	60	26	substrates	substrate	NNS
cord-012045-1cqqj84n	60	27	.	.	.
cord-012045-1cqqj84n	61	1	The	the	DT
cord-012045-1cqqj84n	61	2	ubiquitinated	ubiquitinated	JJ
cord-012045-1cqqj84n	61	3	proteins	protein	NNS
cord-012045-1cqqj84n	61	4	are	be	VBP
cord-012045-1cqqj84n	61	5	then	then	RB
cord-012045-1cqqj84n	61	6	degraded	degrade	VBN
cord-012045-1cqqj84n	61	7	by	by	IN
cord-012045-1cqqj84n	61	8	the	the	DT
cord-012045-1cqqj84n	61	9	proteasome	proteasome	NN
cord-012045-1cqqj84n	61	10	.	.	.
cord-012045-1cqqj84n	62	1	Deubiquitinating	deubiquitinating	NN
cord-012045-1cqqj84n	62	2	enzymes	enzyme	NNS
cord-012045-1cqqj84n	62	3	remove	remove	VBP
cord-012045-1cqqj84n	62	4	the	the	DT
cord-012045-1cqqj84n	62	5	mono	mono	NN
cord-012045-1cqqj84n	62	6	-	-	HYPH
cord-012045-1cqqj84n	62	7	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	62	8	or	or	CC
cord-012045-1cqqj84n	62	9	polyubiquitin	polyubiquitin	VBZ
cord-012045-1cqqj84n	62	10	chains	chain	NNS
cord-012045-1cqqj84n	62	11	from	from	IN
cord-012045-1cqqj84n	62	12	the	the	DT
cord-012045-1cqqj84n	62	13	ubiquitinated	ubiquitinated	JJ
cord-012045-1cqqj84n	62	14	protein	protein	NN
cord-012045-1cqqj84n	62	15	to	to	TO
cord-012045-1cqqj84n	62	16	stabilize	stabilize	VB
cord-012045-1cqqj84n	62	17	the	the	DT
cord-012045-1cqqj84n	62	18	protein	protein	NN
cord-012045-1cqqj84n	62	19	from	from	IN
cord-012045-1cqqj84n	62	20	proteasomal	proteasomal	JJ
cord-012045-1cqqj84n	62	21	degradation	degradation	NN
cord-012045-1cqqj84n	62	22	and	and	CC
cord-012045-1cqqj84n	62	23	recycle	recycle	VB
cord-012045-1cqqj84n	62	24	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	62	25	units	unit	NNS
cord-012045-1cqqj84n	62	26	.	.	.
cord-012045-1cqqj84n	63	1	Ub	Ub	NNS
cord-012045-1cqqj84n	63	2	:	:	:
cord-012045-1cqqj84n	63	3	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	63	4	;	;	:
cord-012045-1cqqj84n	63	5	E1	e1	NN
cord-012045-1cqqj84n	63	6	:	:	:
cord-012045-1cqqj84n	64	1	E1	E1	NNP
cord-012045-1cqqj84n	64	2	Ub	Ub	NNP
cord-012045-1cqqj84n	64	3	-	-	HYPH
cord-012045-1cqqj84n	64	4	activating	activate	VBG
cord-012045-1cqqj84n	64	5	enzyme；E2	enzyme；e2	ADD
cord-012045-1cqqj84n	65	1	:	:	:
cord-012045-1cqqj84n	65	2	E2-Ub	E2-Ub	NNP
cord-012045-1cqqj84n	65	3	-	-	HYPH
cord-012045-1cqqj84n	65	4	conjugating	conjugate	VBG
cord-012045-1cqqj84n	65	5	enzyme，E3	enzyme，e3	NN
cord-012045-1cqqj84n	65	6	:	:	:
cord-012045-1cqqj84n	65	7	E3	E3	NNP
cord-012045-1cqqj84n	65	8	Ub	Ub	NNP
cord-012045-1cqqj84n	65	9	-	-	HYPH
cord-012045-1cqqj84n	65	10	ligases	ligase	NNS
cord-012045-1cqqj84n	65	11	;	;	:
cord-012045-1cqqj84n	65	12	DUB	dub	NN
cord-012045-1cqqj84n	65	13	:	:	:
cord-012045-1cqqj84n	65	14	deubiquitinating	deubiquitinating	NN
cord-012045-1cqqj84n	65	15	enzyme	enzyme	NN
cord-012045-1cqqj84n	65	16	.	.	.
cord-012045-1cqqj84n	66	1	The	the	DT
cord-012045-1cqqj84n	66	2	process	process	NN
cord-012045-1cqqj84n	66	3	of	of	IN
cord-012045-1cqqj84n	66	4	ubiquitination	ubiquitination	NN
cord-012045-1cqqj84n	66	5	is	be	VBZ
cord-012045-1cqqj84n	66	6	reversible	reversible	JJ
cord-012045-1cqqj84n	66	7	,	,	,
cord-012045-1cqqj84n	66	8	a	a	DT
cord-012045-1cqqj84n	66	9	group	group	NN
cord-012045-1cqqj84n	66	10	of	of	IN
cord-012045-1cqqj84n	66	11	enzymes	enzyme	NNS
cord-012045-1cqqj84n	66	12	called	call	VBN
cord-012045-1cqqj84n	66	13	deubiquitination	deubiquitination	NN
cord-012045-1cqqj84n	66	14	enzymes	enzyme	NNS
cord-012045-1cqqj84n	66	15	conduct	conduct	VBP
cord-012045-1cqqj84n	66	16	the	the	DT
cord-012045-1cqqj84n	66	17	enzymatic	enzymatic	JJ
cord-012045-1cqqj84n	66	18	process	process	NN
cord-012045-1cqqj84n	66	19	[	[	-LRB-
cord-012045-1cqqj84n	66	20	22	22	CD
cord-012045-1cqqj84n	66	21	]	]	-RRB-
cord-012045-1cqqj84n	67	1	(	(	-LRB-
cord-012045-1cqqj84n	67	2	Figure	figure	NN
cord-012045-1cqqj84n	67	3	1	1	CD
cord-012045-1cqqj84n	67	4	)	)	-RRB-
cord-012045-1cqqj84n	67	5	.	.	.
cord-012045-1cqqj84n	68	1	Deubiquitination	deubiquitination	NN
cord-012045-1cqqj84n	68	2	is	be	VBZ
cord-012045-1cqqj84n	68	3	the	the	DT
cord-012045-1cqqj84n	68	4	reverse	reverse	JJ
cord-012045-1cqqj84n	68	5	process	process	NN
cord-012045-1cqqj84n	68	6	of	of	IN
cord-012045-1cqqj84n	68	7	ubiquitination	ubiquitination	NN
cord-012045-1cqqj84n	68	8	,	,	,
cord-012045-1cqqj84n	68	9	that	that	WDT
cord-012045-1cqqj84n	68	10	removes	remove	VBZ
cord-012045-1cqqj84n	68	11	the	the	DT
cord-012045-1cqqj84n	68	12	mono	mono	NN
cord-012045-1cqqj84n	68	13	-	-	HYPH
cord-012045-1cqqj84n	68	14	ubiquitin	ubiquitin	JJ
cord-012045-1cqqj84n	68	15	and	and	CC
cord-012045-1cqqj84n	68	16	poly	poly	JJ
cord-012045-1cqqj84n	68	17	-	-	HYPH
cord-012045-1cqqj84n	68	18	ubiquitin	ubiquitin	JJ
cord-012045-1cqqj84n	68	19	chains	chain	NNS
cord-012045-1cqqj84n	68	20	from	from	IN
cord-012045-1cqqj84n	68	21	the	the	DT
cord-012045-1cqqj84n	68	22	modified	modify	VBN
cord-012045-1cqqj84n	68	23	proteins	protein	NNS
cord-012045-1cqqj84n	68	24	to	to	TO
cord-012045-1cqqj84n	68	25	generate	generate	VB
cord-012045-1cqqj84n	68	26	free	free	JJ
cord-012045-1cqqj84n	68	27	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	68	28	,	,	,
cord-012045-1cqqj84n	68	29	which	which	WDT
cord-012045-1cqqj84n	68	30	terminates	terminate	VBZ
cord-012045-1cqqj84n	68	31	the	the	DT
cord-012045-1cqqj84n	68	32	function	function	NN
cord-012045-1cqqj84n	68	33	of	of	IN
cord-012045-1cqqj84n	68	34	ubiquitinated	ubiquitinated	JJ
cord-012045-1cqqj84n	68	35	protein	protein	NN
cord-012045-1cqqj84n	68	36	,	,	,
cord-012045-1cqqj84n	68	37	and	and	CC
cord-012045-1cqqj84n	68	38	specifically	specifically	RB
cord-012045-1cqqj84n	68	39	,	,	,
cord-012045-1cqqj84n	68	40	stabilizes	stabilize	VBZ
cord-012045-1cqqj84n	68	41	the	the	DT
cord-012045-1cqqj84n	68	42	ubiquitinated	ubiquitinated	JJ
cord-012045-1cqqj84n	68	43	protein	protein	NN
cord-012045-1cqqj84n	68	44	from	from	IN
cord-012045-1cqqj84n	68	45	degradation	degradation	NN
cord-012045-1cqqj84n	68	46	.	.	.
cord-012045-1cqqj84n	69	1	Deubiquitination	Deubiquitination	NNP
cord-012045-1cqqj84n	69	2	also	also	RB
cord-012045-1cqqj84n	69	3	replenishes	replenish	VBZ
cord-012045-1cqqj84n	69	4	the	the	DT
cord-012045-1cqqj84n	69	5	ubiquitin	ubiquitin	JJ
cord-012045-1cqqj84n	69	6	pool	pool	NN
cord-012045-1cqqj84n	69	7	,	,	,
cord-012045-1cqqj84n	69	8	and	and	CC
cord-012045-1cqqj84n	69	9	maintains	maintain	VBZ
cord-012045-1cqqj84n	69	10	homeostasis	homeostasis	NN
cord-012045-1cqqj84n	69	11	of	of	IN
cord-012045-1cqqj84n	69	12	the	the	DT
cord-012045-1cqqj84n	69	13	cellular	cellular	JJ
cord-012045-1cqqj84n	69	14	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	69	15	[	[	-LRB-
cord-012045-1cqqj84n	69	16	23	23	CD
cord-012045-1cqqj84n	69	17	]	]	-RRB-
cord-012045-1cqqj84n	69	18	.	.	.
cord-012045-1cqqj84n	70	1	This	this	DT
cord-012045-1cqqj84n	70	2	process	process	NN
cord-012045-1cqqj84n	70	3	is	be	VBZ
cord-012045-1cqqj84n	70	4	performed	perform	VBN
cord-012045-1cqqj84n	70	5	by	by	IN
cord-012045-1cqqj84n	70	6	deubiquitinating	deubiquitinate	VBG
cord-012045-1cqqj84n	70	7	enzymes	enzyme	NNS
cord-012045-1cqqj84n	70	8	(	(	-LRB-
cord-012045-1cqqj84n	70	9	DUBs	dub	NNS
cord-012045-1cqqj84n	70	10	)	)	-RRB-
cord-012045-1cqqj84n	70	11	,	,	,
cord-012045-1cqqj84n	70	12	which	which	WDT
cord-012045-1cqqj84n	70	13	are	be	VBP
cord-012045-1cqqj84n	70	14	a	a	DT
cord-012045-1cqqj84n	70	15	large	large	JJ
cord-012045-1cqqj84n	70	16	set	set	NN
cord-012045-1cqqj84n	70	17	of	of	IN
cord-012045-1cqqj84n	70	18	proteases	protease	NNS
cord-012045-1cqqj84n	70	19	.	.	.
cord-012045-1cqqj84n	71	1	The	the	DT
cord-012045-1cqqj84n	71	2	number	number	NN
cord-012045-1cqqj84n	71	3	of	of	IN
cord-012045-1cqqj84n	71	4	DUBs	dub	NNS
cord-012045-1cqqj84n	71	5	in	in	IN
cord-012045-1cqqj84n	71	6	humans	human	NNS
cord-012045-1cqqj84n	71	7	is	be	VBZ
cord-012045-1cqqj84n	71	8	about	about	RB
cord-012045-1cqqj84n	71	9	100	100	CD
cord-012045-1cqqj84n	71	10	,	,	,
cord-012045-1cqqj84n	71	11	while	while	IN
cord-012045-1cqqj84n	71	12	~20	~20	NFP
cord-012045-1cqqj84n	71	13	DUBs	dub	NNS
cord-012045-1cqqj84n	71	14	exist	exist	VBP
cord-012045-1cqqj84n	71	15	in	in	IN
cord-012045-1cqqj84n	71	16	the	the	DT
cord-012045-1cqqj84n	71	17	yeast	yeast	NN
cord-012045-1cqqj84n	71	18	Saccharomyces	saccharomyce	NNS
cord-012045-1cqqj84n	71	19	cerevisiae	cerevisiae	NNS
cord-012045-1cqqj84n	71	20	[	[	-LRB-
cord-012045-1cqqj84n	71	21	24	24	CD
cord-012045-1cqqj84n	71	22	]	]	-RRB-
cord-012045-1cqqj84n	72	1	[	[	-LRB-
cord-012045-1cqqj84n	72	2	25	25	CD
cord-012045-1cqqj84n	72	3	]	]	-RRB-
cord-012045-1cqqj84n	72	4	[	[	-LRB-
cord-012045-1cqqj84n	72	5	26	26	CD
cord-012045-1cqqj84n	72	6	]	]	-RRB-
cord-012045-1cqqj84n	72	7	.	.	.
cord-012045-1cqqj84n	73	1	A	a	DT
cord-012045-1cqqj84n	73	2	number	number	NN
cord-012045-1cqqj84n	73	3	of	of	IN
cord-012045-1cqqj84n	73	4	approaches	approach	NNS
cord-012045-1cqqj84n	73	5	are	be	VBP
cord-012045-1cqqj84n	73	6	utilized	utilize	VBN
cord-012045-1cqqj84n	73	7	in	in	IN
cord-012045-1cqqj84n	73	8	studying	study	VBG
cord-012045-1cqqj84n	73	9	DUBs	dub	NNS
cord-012045-1cqqj84n	73	10	and	and	CC
cord-012045-1cqqj84n	73	11	the	the	DT
cord-012045-1cqqj84n	73	12	related	related	JJ
cord-012045-1cqqj84n	73	13	diseases	disease	NNS
cord-012045-1cqqj84n	73	14	.	.	.
cord-012045-1cqqj84n	74	1	These	these	DT
cord-012045-1cqqj84n	74	2	approaches	approach	NNS
cord-012045-1cqqj84n	74	3	include	include	VBP
cord-012045-1cqqj84n	74	4	conventional	conventional	JJ
cord-012045-1cqqj84n	74	5	protein	protein	NN
cord-012045-1cqqj84n	74	6	-	-	HYPH
cord-012045-1cqqj84n	74	7	protein	protein	NN
cord-012045-1cqqj84n	74	8	interaction	interaction	NN
cord-012045-1cqqj84n	74	9	techniques	technique	NNS
cord-012045-1cqqj84n	74	10	such	such	JJ
cord-012045-1cqqj84n	74	11	as	as	IN
cord-012045-1cqqj84n	74	12	immunoprecipitation	immunoprecipitation	NN
cord-012045-1cqqj84n	74	13	,	,	,
cord-012045-1cqqj84n	74	14	enzymatic	enzymatic	JJ
cord-012045-1cqqj84n	74	15	assays	assay	NNS
cord-012045-1cqqj84n	74	16	,	,	,
cord-012045-1cqqj84n	74	17	bioinformatics	bioinformatic	NNS
cord-012045-1cqqj84n	74	18	,	,	,
cord-012045-1cqqj84n	74	19	proteomic	proteomic	JJ
cord-012045-1cqqj84n	74	20	,	,	,
cord-012045-1cqqj84n	74	21	transcriptomic	transcriptomic	NNP
cord-012045-1cqqj84n	74	22	,	,	,
cord-012045-1cqqj84n	74	23	and	and	CC
cord-012045-1cqqj84n	74	24	structure	structure	NN
cord-012045-1cqqj84n	74	25	analysis	analysis	NN
cord-012045-1cqqj84n	74	26	techniques	technique	NNS
cord-012045-1cqqj84n	74	27	.	.	.
cord-012045-1cqqj84n	75	1	Based	base	VBN
cord-012045-1cqqj84n	75	2	on	on	IN
cord-012045-1cqqj84n	75	3	the	the	DT
cord-012045-1cqqj84n	75	4	architecture	architecture	NN
cord-012045-1cqqj84n	75	5	of	of	IN
cord-012045-1cqqj84n	75	6	their	-PRON-	PRP$
cord-012045-1cqqj84n	75	7	catalytic	catalytic	JJ
cord-012045-1cqqj84n	75	8	domains	domain	NNS
cord-012045-1cqqj84n	75	9	,	,	,
cord-012045-1cqqj84n	75	10	to	to	IN
cord-012045-1cqqj84n	75	11	date	date	NN
cord-012045-1cqqj84n	75	12	,	,	,
cord-012045-1cqqj84n	75	13	six	six	CD
cord-012045-1cqqj84n	75	14	structurally	structurally	RB
cord-012045-1cqqj84n	75	15	distinct	distinct	JJ
cord-012045-1cqqj84n	75	16	DUB	DUB	NNP
cord-012045-1cqqj84n	75	17	families	family	NNS
cord-012045-1cqqj84n	75	18	have	have	VBP
cord-012045-1cqqj84n	75	19	been	be	VBN
cord-012045-1cqqj84n	75	20	described	describe	VBN
cord-012045-1cqqj84n	75	21	[	[	-LRB-
cord-012045-1cqqj84n	75	22	27	27	CD
cord-012045-1cqqj84n	75	23	]	]	-RRB-
cord-012045-1cqqj84n	75	24	.	.	.
cord-012045-1cqqj84n	76	1	Five	five	CD
cord-012045-1cqqj84n	76	2	families	family	NNS
cord-012045-1cqqj84n	76	3	of	of	IN
cord-012045-1cqqj84n	76	4	DUBs	dub	NNS
cord-012045-1cqqj84n	76	5	are	be	VBP
cord-012045-1cqqj84n	76	6	cysteine	cysteine	NN
cord-012045-1cqqj84n	76	7	proteases	protease	NNS
cord-012045-1cqqj84n	76	8	,	,	,
cord-012045-1cqqj84n	76	9	including54	including54	NN
cord-012045-1cqqj84n	76	10	members	member	NNS
cord-012045-1cqqj84n	76	11	of	of	IN
cord-012045-1cqqj84n	76	12	USPs(ubiquitin	usps(ubiquitin	JJ
cord-012045-1cqqj84n	76	13	-	-	HYPH
cord-012045-1cqqj84n	76	14	specific	specific	JJ
cord-012045-1cqqj84n	76	15	proteases)in	proteases)in	NNP
cord-012045-1cqqj84n	76	16	humans	human	NNS
cord-012045-1cqqj84n	76	17	,	,	,
cord-012045-1cqqj84n	76	18	four	four	CD
cord-012045-1cqqj84n	76	19	members	member	NNS
cord-012045-1cqqj84n	76	20	of	of	IN
cord-012045-1cqqj84n	76	21	UCHs(ubiquitin	UCHs(ubiquitin	NNP
cord-012045-1cqqj84n	76	22	carboxy	carboxy	JJ
cord-012045-1cqqj84n	76	23	-	-	HYPH
cord-012045-1cqqj84n	76	24	terminal	terminal	NN
cord-012045-1cqqj84n	76	25	hydrolases	hydrolase	NNS
cord-012045-1cqqj84n	76	26	)	)	-RRB-
cord-012045-1cqqj84n	76	27	,	,	,
cord-012045-1cqqj84n	76	28	16	16	CD
cord-012045-1cqqj84n	76	29	members	member	NNS
cord-012045-1cqqj84n	76	30	of	of	IN
cord-012045-1cqqj84n	76	31	OTUs(ovarian	otus(ovarian	JJ
cord-012045-1cqqj84n	76	32	tumor	tumor	NN
cord-012045-1cqqj84n	76	33	proteases	protease	NNS
cord-012045-1cqqj84n	76	34	)	)	-RRB-
cord-012045-1cqqj84n	76	35	,	,	,
cord-012045-1cqqj84n	76	36	four	four	CD
cord-012045-1cqqj84n	76	37	members	member	NNS
cord-012045-1cqqj84n	76	38	of	of	IN
cord-012045-1cqqj84n	76	39	MJDs	mjd	NNS
cord-012045-1cqqj84n	76	40	(	(	-LRB-
cord-012045-1cqqj84n	76	41	Machado	Machado	NNP
cord-012045-1cqqj84n	76	42	-	-	HYPH
cord-012045-1cqqj84n	76	43	Josephin	Josephin	NNP
cord-012045-1cqqj84n	76	44	disease	disease	NN
cord-012045-1cqqj84n	76	45	protein	protein	NN
cord-012045-1cqqj84n	76	46	domain	domain	NN
cord-012045-1cqqj84n	76	47	protease	protease	NN
cord-012045-1cqqj84n	76	48	)	)	-RRB-
cord-012045-1cqqj84n	76	49	[	[	-LRB-
cord-012045-1cqqj84n	76	50	25	25	CD
cord-012045-1cqqj84n	76	51	,	,	,
cord-012045-1cqqj84n	76	52	26	26	CD
cord-012045-1cqqj84n	76	53	]	]	-RRB-
cord-012045-1cqqj84n	76	54	,	,	,
cord-012045-1cqqj84n	76	55	and	and	CC
cord-012045-1cqqj84n	76	56	four	four	CD
cord-012045-1cqqj84n	76	57	members	member	NNS
cord-012045-1cqqj84n	76	58	of	of	IN
cord-012045-1cqqj84n	76	59	MINDYs	mindys	NN
cord-012045-1cqqj84n	76	60	(	(	-LRB-
cord-012045-1cqqj84n	76	61	motif	motif	NN
cord-012045-1cqqj84n	76	62	interacting	interact	VBG
cord-012045-1cqqj84n	76	63	with	with	IN
cord-012045-1cqqj84n	76	64	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	76	65	(	(	-LRB-
cord-012045-1cqqj84n	76	66	MIU)-containing	miu)-containe	VBG
cord-012045-1cqqj84n	76	67	novel	novel	JJ
cord-012045-1cqqj84n	76	68	DUB	DUB	NNP
cord-012045-1cqqj84n	76	69	family	family	NN
cord-012045-1cqqj84n	76	70	)	)	-RRB-
cord-012045-1cqqj84n	76	71	[	[	-LRB-
cord-012045-1cqqj84n	76	72	28	28	CD
cord-012045-1cqqj84n	76	73	]	]	-RRB-
cord-012045-1cqqj84n	76	74	.	.	.
cord-012045-1cqqj84n	77	1	The	the	DT
cord-012045-1cqqj84n	77	2	sixth	sixth	JJ
cord-012045-1cqqj84n	77	3	subfamily	subfamily	NN
cord-012045-1cqqj84n	77	4	is	be	VBZ
cord-012045-1cqqj84n	77	5	JAMMs	jamm	NNS
cord-012045-1cqqj84n	77	6	(	(	-LRB-
cord-012045-1cqqj84n	77	7	Zn	Zn	NNP
cord-012045-1cqqj84n	77	8	-	-	HYPH
cord-012045-1cqqj84n	77	9	JAB1	JAB1	NNP
cord-012045-1cqqj84n	77	10	/	/	SYM
cord-012045-1cqqj84n	77	11	MPN	MPN	NNP
cord-012045-1cqqj84n	77	12	/	/	SYM
cord-012045-1cqqj84n	77	13	MOV34	MOV34	NNP
cord-012045-1cqqj84n	77	14	domain	domain	NN
cord-012045-1cqqj84n	77	15	protease	protease	NN
cord-012045-1cqqj84n	77	16	)	)	-RRB-
cord-012045-1cqqj84n	77	17	,	,	,
cord-012045-1cqqj84n	77	18	which	which	WDT
cord-012045-1cqqj84n	77	19	includes	include	VBZ
cord-012045-1cqqj84n	77	20	a	a	DT
cord-012045-1cqqj84n	77	21	conserved	conserved	JJ
cord-012045-1cqqj84n	77	22	zinc	zinc	NN
cord-012045-1cqqj84n	77	23	metallopeptidase	metallopeptidase	NN
cord-012045-1cqqj84n	77	24	[	[	-LRB-
cord-012045-1cqqj84n	77	25	25	25	CD
cord-012045-1cqqj84n	77	26	,	,	,
cord-012045-1cqqj84n	77	27	26	26	CD
cord-012045-1cqqj84n	77	28	]	]	-RRB-
cord-012045-1cqqj84n	77	29	.	.	.
cord-012045-1cqqj84n	78	1	All	all	DT
cord-012045-1cqqj84n	78	2	DUB	DUB	NNP
cord-012045-1cqqj84n	78	3	family	family	NN
cord-012045-1cqqj84n	78	4	members	member	NNS
cord-012045-1cqqj84n	78	5	bear	bear	VBP
cord-012045-1cqqj84n	78	6	a	a	DT
cord-012045-1cqqj84n	78	7	catalytic	catalytic	JJ
cord-012045-1cqqj84n	78	8	domain	domain	NN
cord-012045-1cqqj84n	78	9	that	that	WDT
cord-012045-1cqqj84n	78	10	removes	remove	VBZ
cord-012045-1cqqj84n	78	11	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	78	12	from	from	IN
cord-012045-1cqqj84n	78	13	the	the	DT
cord-012045-1cqqj84n	78	14	protein	protein	NN
cord-012045-1cqqj84n	78	15	substrates	substrate	NNS
cord-012045-1cqqj84n	78	16	[	[	-LRB-
cord-012045-1cqqj84n	78	17	27	27	CD
cord-012045-1cqqj84n	78	18	]	]	-RRB-
cord-012045-1cqqj84n	78	19	.	.	.
cord-012045-1cqqj84n	79	1	The	the	DT
cord-012045-1cqqj84n	79	2	catalytic	catalytic	JJ
cord-012045-1cqqj84n	79	3	domain	domain	NN
cord-012045-1cqqj84n	79	4	of	of	IN
cord-012045-1cqqj84n	79	5	MIU	MIU	NNP
cord-012045-1cqqj84n	79	6	family	family	NN
cord-012045-1cqqj84n	79	7	sub	sub	NN
cord-012045-1cqqj84n	79	8	-	-	NNS
cord-012045-1cqqj84n	79	9	members	member	NNS
cord-012045-1cqqj84n	79	10	is	be	VBZ
cord-012045-1cqqj84n	79	11	a	a	DT
cord-012045-1cqqj84n	79	12	new	new	JJ
cord-012045-1cqqj84n	79	13	folding	folding	NN
cord-012045-1cqqj84n	79	14	variant	variant	NN
cord-012045-1cqqj84n	79	15	within	within	IN
cord-012045-1cqqj84n	79	16	the	the	DT
cord-012045-1cqqj84n	79	17	superfamily	superfamily	NN
cord-012045-1cqqj84n	79	18	of	of	IN
cord-012045-1cqqj84n	79	19	cysteine	cysteine	JJ
cord-012045-1cqqj84n	79	20	protease	protease	NN
cord-012045-1cqqj84n	79	21	and	and	CC
cord-012045-1cqqj84n	79	22	shows	show	VBZ
cord-012045-1cqqj84n	79	23	a	a	DT
cord-012045-1cqqj84n	79	24	remarkable	remarkable	JJ
cord-012045-1cqqj84n	79	25	selectivity	selectivity	NN
cord-012045-1cqqj84n	79	26	for	for	IN
cord-012045-1cqqj84n	79	27	cleaving	cleave	VBG
cord-012045-1cqqj84n	79	28	long	long	JJ
cord-012045-1cqqj84n	79	29	lysine	lysine	NN
cord-012045-1cqqj84n	79	30	48	48	CD
cord-012045-1cqqj84n	79	31	(	(	-LRB-
cord-012045-1cqqj84n	79	32	K48)-linked	k48)-linked	JJ
cord-012045-1cqqj84n	79	33	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	79	34	chains	chain	NNS
cord-012045-1cqqj84n	79	35	.	.	.
cord-012045-1cqqj84n	80	1	In	in	IN
cord-012045-1cqqj84n	80	2	particular	particular	JJ
cord-012045-1cqqj84n	80	3	,	,	,
cord-012045-1cqqj84n	80	4	cleavage	cleavage	NN
cord-012045-1cqqj84n	80	5	selectivity	selectivity	NN
cord-012045-1cqqj84n	80	6	of	of	IN
cord-012045-1cqqj84n	80	7	DUBs	dub	NNS
cord-012045-1cqqj84n	80	8	is	be	VBZ
cord-012045-1cqqj84n	80	9	determined	determine	VBN
cord-012045-1cqqj84n	80	10	by	by	IN
cord-012045-1cqqj84n	80	11	catalytic	catalytic	JJ
cord-012045-1cqqj84n	80	12	The	the	DT
cord-012045-1cqqj84n	80	13	process	process	NN
cord-012045-1cqqj84n	80	14	of	of	IN
cord-012045-1cqqj84n	80	15	ubiquitination	ubiquitination	NN
cord-012045-1cqqj84n	80	16	is	be	VBZ
cord-012045-1cqqj84n	80	17	reversible	reversible	JJ
cord-012045-1cqqj84n	80	18	,	,	,
cord-012045-1cqqj84n	80	19	a	a	DT
cord-012045-1cqqj84n	80	20	group	group	NN
cord-012045-1cqqj84n	80	21	of	of	IN
cord-012045-1cqqj84n	80	22	enzymes	enzyme	NNS
cord-012045-1cqqj84n	80	23	called	call	VBN
cord-012045-1cqqj84n	80	24	deubiquitination	deubiquitination	NN
cord-012045-1cqqj84n	80	25	enzymes	enzyme	NNS
cord-012045-1cqqj84n	80	26	conduct	conduct	VBP
cord-012045-1cqqj84n	80	27	the	the	DT
cord-012045-1cqqj84n	80	28	enzymatic	enzymatic	JJ
cord-012045-1cqqj84n	80	29	process	process	NN
cord-012045-1cqqj84n	80	30	[	[	-LRB-
cord-012045-1cqqj84n	80	31	22	22	CD
cord-012045-1cqqj84n	80	32	]	]	-RRB-
cord-012045-1cqqj84n	81	1	(	(	-LRB-
cord-012045-1cqqj84n	81	2	Figure	figure	NN
cord-012045-1cqqj84n	81	3	1	1	CD
cord-012045-1cqqj84n	81	4	)	)	-RRB-
cord-012045-1cqqj84n	81	5	.	.	.
cord-012045-1cqqj84n	82	1	Deubiquitination	deubiquitination	NN
cord-012045-1cqqj84n	82	2	is	be	VBZ
cord-012045-1cqqj84n	82	3	the	the	DT
cord-012045-1cqqj84n	82	4	reverse	reverse	JJ
cord-012045-1cqqj84n	82	5	process	process	NN
cord-012045-1cqqj84n	82	6	of	of	IN
cord-012045-1cqqj84n	82	7	ubiquitination	ubiquitination	NN
cord-012045-1cqqj84n	82	8	,	,	,
cord-012045-1cqqj84n	82	9	that	that	WDT
cord-012045-1cqqj84n	82	10	removes	remove	VBZ
cord-012045-1cqqj84n	82	11	the	the	DT
cord-012045-1cqqj84n	82	12	mono	mono	NN
cord-012045-1cqqj84n	82	13	-	-	HYPH
cord-012045-1cqqj84n	82	14	ubiquitin	ubiquitin	JJ
cord-012045-1cqqj84n	82	15	and	and	CC
cord-012045-1cqqj84n	82	16	poly	poly	JJ
cord-012045-1cqqj84n	82	17	-	-	HYPH
cord-012045-1cqqj84n	82	18	ubiquitin	ubiquitin	JJ
cord-012045-1cqqj84n	82	19	chains	chain	NNS
cord-012045-1cqqj84n	82	20	from	from	IN
cord-012045-1cqqj84n	82	21	the	the	DT
cord-012045-1cqqj84n	82	22	modified	modify	VBN
cord-012045-1cqqj84n	82	23	proteins	protein	NNS
cord-012045-1cqqj84n	82	24	to	to	TO
cord-012045-1cqqj84n	82	25	generate	generate	VB
cord-012045-1cqqj84n	82	26	free	free	JJ
cord-012045-1cqqj84n	82	27	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	82	28	,	,	,
cord-012045-1cqqj84n	82	29	which	which	WDT
cord-012045-1cqqj84n	82	30	terminates	terminate	VBZ
cord-012045-1cqqj84n	82	31	the	the	DT
cord-012045-1cqqj84n	82	32	function	function	NN
cord-012045-1cqqj84n	82	33	of	of	IN
cord-012045-1cqqj84n	82	34	ubiquitinated	ubiquitinated	JJ
cord-012045-1cqqj84n	82	35	protein	protein	NN
cord-012045-1cqqj84n	82	36	,	,	,
cord-012045-1cqqj84n	82	37	and	and	CC
cord-012045-1cqqj84n	82	38	specifically	specifically	RB
cord-012045-1cqqj84n	82	39	,	,	,
cord-012045-1cqqj84n	82	40	stabilizes	stabilize	VBZ
cord-012045-1cqqj84n	82	41	the	the	DT
cord-012045-1cqqj84n	82	42	ubiquitinated	ubiquitinated	JJ
cord-012045-1cqqj84n	82	43	protein	protein	NN
cord-012045-1cqqj84n	82	44	from	from	IN
cord-012045-1cqqj84n	82	45	degradation	degradation	NN
cord-012045-1cqqj84n	82	46	.	.	.
cord-012045-1cqqj84n	83	1	Deubiquitination	Deubiquitination	NNP
cord-012045-1cqqj84n	83	2	also	also	RB
cord-012045-1cqqj84n	83	3	replenishes	replenish	VBZ
cord-012045-1cqqj84n	83	4	the	the	DT
cord-012045-1cqqj84n	83	5	ubiquitin	ubiquitin	JJ
cord-012045-1cqqj84n	83	6	pool	pool	NN
cord-012045-1cqqj84n	83	7	,	,	,
cord-012045-1cqqj84n	83	8	and	and	CC
cord-012045-1cqqj84n	83	9	maintains	maintain	VBZ
cord-012045-1cqqj84n	83	10	homeostasis	homeostasis	NN
cord-012045-1cqqj84n	83	11	of	of	IN
cord-012045-1cqqj84n	83	12	the	the	DT
cord-012045-1cqqj84n	83	13	cellular	cellular	JJ
cord-012045-1cqqj84n	83	14	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	83	15	[	[	-LRB-
cord-012045-1cqqj84n	83	16	23	23	CD
cord-012045-1cqqj84n	83	17	]	]	-RRB-
cord-012045-1cqqj84n	83	18	.	.	.
cord-012045-1cqqj84n	84	1	This	this	DT
cord-012045-1cqqj84n	84	2	process	process	NN
cord-012045-1cqqj84n	84	3	is	be	VBZ
cord-012045-1cqqj84n	84	4	performed	perform	VBN
cord-012045-1cqqj84n	84	5	by	by	IN
cord-012045-1cqqj84n	84	6	deubiquitinating	deubiquitinate	VBG
cord-012045-1cqqj84n	84	7	enzymes	enzyme	NNS
cord-012045-1cqqj84n	84	8	(	(	-LRB-
cord-012045-1cqqj84n	84	9	DUBs	dub	NNS
cord-012045-1cqqj84n	84	10	)	)	-RRB-
cord-012045-1cqqj84n	84	11	,	,	,
cord-012045-1cqqj84n	84	12	which	which	WDT
cord-012045-1cqqj84n	84	13	are	be	VBP
cord-012045-1cqqj84n	84	14	a	a	DT
cord-012045-1cqqj84n	84	15	large	large	JJ
cord-012045-1cqqj84n	84	16	set	set	NN
cord-012045-1cqqj84n	84	17	of	of	IN
cord-012045-1cqqj84n	84	18	proteases	protease	NNS
cord-012045-1cqqj84n	84	19	.	.	.
cord-012045-1cqqj84n	85	1	The	the	DT
cord-012045-1cqqj84n	85	2	number	number	NN
cord-012045-1cqqj84n	85	3	of	of	IN
cord-012045-1cqqj84n	85	4	DUBs	dub	NNS
cord-012045-1cqqj84n	85	5	in	in	IN
cord-012045-1cqqj84n	85	6	humans	human	NNS
cord-012045-1cqqj84n	85	7	is	be	VBZ
cord-012045-1cqqj84n	85	8	about	about	RB
cord-012045-1cqqj84n	85	9	100	100	CD
cord-012045-1cqqj84n	85	10	,	,	,
cord-012045-1cqqj84n	85	11	while~20	while~20	NNP
cord-012045-1cqqj84n	85	12	DUBs	dub	NNS
cord-012045-1cqqj84n	85	13	exist	exist	VBP
cord-012045-1cqqj84n	85	14	in	in	IN
cord-012045-1cqqj84n	85	15	the	the	DT
cord-012045-1cqqj84n	85	16	yeast	yeast	NN
cord-012045-1cqqj84n	85	17	Saccharomyces	saccharomyce	NNS
cord-012045-1cqqj84n	85	18	cerevisiae	cerevisiae	NNS
cord-012045-1cqqj84n	85	19	[	[	-LRB-
cord-012045-1cqqj84n	85	20	24	24	CD
cord-012045-1cqqj84n	85	21	]	]	-RRB-
cord-012045-1cqqj84n	85	22	[	[	-LRB-
cord-012045-1cqqj84n	85	23	25	25	CD
cord-012045-1cqqj84n	85	24	]	]	-RRB-
cord-012045-1cqqj84n	85	25	[	[	-LRB-
cord-012045-1cqqj84n	85	26	26	26	CD
cord-012045-1cqqj84n	85	27	]	]	-RRB-
cord-012045-1cqqj84n	85	28	.	.	.
cord-012045-1cqqj84n	86	1	A	a	DT
cord-012045-1cqqj84n	86	2	number	number	NN
cord-012045-1cqqj84n	86	3	of	of	IN
cord-012045-1cqqj84n	86	4	approaches	approach	NNS
cord-012045-1cqqj84n	86	5	are	be	VBP
cord-012045-1cqqj84n	86	6	utilized	utilize	VBN
cord-012045-1cqqj84n	86	7	in	in	IN
cord-012045-1cqqj84n	86	8	studying	study	VBG
cord-012045-1cqqj84n	86	9	DUBs	dub	NNS
cord-012045-1cqqj84n	86	10	and	and	CC
cord-012045-1cqqj84n	86	11	the	the	DT
cord-012045-1cqqj84n	86	12	related	related	JJ
cord-012045-1cqqj84n	86	13	diseases	disease	NNS
cord-012045-1cqqj84n	86	14	.	.	.
cord-012045-1cqqj84n	87	1	These	these	DT
cord-012045-1cqqj84n	87	2	approaches	approach	NNS
cord-012045-1cqqj84n	87	3	include	include	VBP
cord-012045-1cqqj84n	87	4	conventional	conventional	JJ
cord-012045-1cqqj84n	87	5	protein	protein	NN
cord-012045-1cqqj84n	87	6	-	-	HYPH
cord-012045-1cqqj84n	87	7	protein	protein	NN
cord-012045-1cqqj84n	87	8	interaction	interaction	NN
cord-012045-1cqqj84n	87	9	techniques	technique	NNS
cord-012045-1cqqj84n	87	10	such	such	JJ
cord-012045-1cqqj84n	87	11	as	as	IN
cord-012045-1cqqj84n	87	12	immunoprecipitation	immunoprecipitation	NN
cord-012045-1cqqj84n	87	13	,	,	,
cord-012045-1cqqj84n	87	14	enzymatic	enzymatic	JJ
cord-012045-1cqqj84n	87	15	assays	assay	NNS
cord-012045-1cqqj84n	87	16	,	,	,
cord-012045-1cqqj84n	87	17	bioinformatics	bioinformatic	NNS
cord-012045-1cqqj84n	87	18	,	,	,
cord-012045-1cqqj84n	87	19	proteomic	proteomic	JJ
cord-012045-1cqqj84n	87	20	,	,	,
cord-012045-1cqqj84n	87	21	transcriptomic	transcriptomic	NNP
cord-012045-1cqqj84n	87	22	,	,	,
cord-012045-1cqqj84n	87	23	and	and	CC
cord-012045-1cqqj84n	87	24	structure	structure	NN
cord-012045-1cqqj84n	87	25	analysis	analysis	NN
cord-012045-1cqqj84n	87	26	techniques	technique	NNS
cord-012045-1cqqj84n	87	27	.	.	.
cord-012045-1cqqj84n	88	1	Based	base	VBN
cord-012045-1cqqj84n	88	2	on	on	IN
cord-012045-1cqqj84n	88	3	the	the	DT
cord-012045-1cqqj84n	88	4	architecture	architecture	NN
cord-012045-1cqqj84n	88	5	of	of	IN
cord-012045-1cqqj84n	88	6	their	-PRON-	PRP$
cord-012045-1cqqj84n	88	7	catalytic	catalytic	JJ
cord-012045-1cqqj84n	88	8	domains	domain	NNS
cord-012045-1cqqj84n	88	9	,	,	,
cord-012045-1cqqj84n	88	10	to	to	IN
cord-012045-1cqqj84n	88	11	date	date	NN
cord-012045-1cqqj84n	88	12	,	,	,
cord-012045-1cqqj84n	88	13	six	six	CD
cord-012045-1cqqj84n	88	14	structurally	structurally	RB
cord-012045-1cqqj84n	88	15	distinct	distinct	JJ
cord-012045-1cqqj84n	88	16	DUB	DUB	NNP
cord-012045-1cqqj84n	88	17	families	family	NNS
cord-012045-1cqqj84n	88	18	have	have	VBP
cord-012045-1cqqj84n	88	19	been	be	VBN
cord-012045-1cqqj84n	88	20	described	describe	VBN
cord-012045-1cqqj84n	88	21	[	[	-LRB-
cord-012045-1cqqj84n	88	22	27	27	CD
cord-012045-1cqqj84n	88	23	]	]	-RRB-
cord-012045-1cqqj84n	88	24	.	.	.
cord-012045-1cqqj84n	89	1	Five	five	CD
cord-012045-1cqqj84n	89	2	families	family	NNS
cord-012045-1cqqj84n	89	3	of	of	IN
cord-012045-1cqqj84n	89	4	DUBs	dub	NNS
cord-012045-1cqqj84n	89	5	are	be	VBP
cord-012045-1cqqj84n	89	6	cysteine	cysteine	NN
cord-012045-1cqqj84n	89	7	proteases	protease	NNS
cord-012045-1cqqj84n	89	8	,	,	,
cord-012045-1cqqj84n	89	9	including54	including54	NN
cord-012045-1cqqj84n	89	10	members	member	NNS
cord-012045-1cqqj84n	89	11	of	of	IN
cord-012045-1cqqj84n	89	12	USPs(ubiquitin	usps(ubiquitin	JJ
cord-012045-1cqqj84n	89	13	-	-	HYPH
cord-012045-1cqqj84n	89	14	specific	specific	JJ
cord-012045-1cqqj84n	89	15	proteases)in	proteases)in	NNP
cord-012045-1cqqj84n	89	16	humans	human	NNS
cord-012045-1cqqj84n	89	17	,	,	,
cord-012045-1cqqj84n	89	18	four	four	CD
cord-012045-1cqqj84n	89	19	members	member	NNS
cord-012045-1cqqj84n	89	20	of	of	IN
cord-012045-1cqqj84n	89	21	UCHs(ubiquitin	UCHs(ubiquitin	NNP
cord-012045-1cqqj84n	89	22	carboxy	carboxy	JJ
cord-012045-1cqqj84n	89	23	-	-	HYPH
cord-012045-1cqqj84n	89	24	terminal	terminal	NN
cord-012045-1cqqj84n	89	25	hydrolases	hydrolase	NNS
cord-012045-1cqqj84n	89	26	)	)	-RRB-
cord-012045-1cqqj84n	89	27	,	,	,
cord-012045-1cqqj84n	89	28	16	16	CD
cord-012045-1cqqj84n	89	29	members	member	NNS
cord-012045-1cqqj84n	89	30	of	of	IN
cord-012045-1cqqj84n	89	31	OTUs(ovarian	otus(ovarian	JJ
cord-012045-1cqqj84n	89	32	tumor	tumor	NN
cord-012045-1cqqj84n	89	33	proteases	protease	NNS
cord-012045-1cqqj84n	89	34	)	)	-RRB-
cord-012045-1cqqj84n	89	35	,	,	,
cord-012045-1cqqj84n	89	36	four	four	CD
cord-012045-1cqqj84n	89	37	members	member	NNS
cord-012045-1cqqj84n	89	38	of	of	IN
cord-012045-1cqqj84n	89	39	MJDs	mjd	NNS
cord-012045-1cqqj84n	89	40	(	(	-LRB-
cord-012045-1cqqj84n	89	41	Machado	Machado	NNP
cord-012045-1cqqj84n	89	42	-	-	HYPH
cord-012045-1cqqj84n	89	43	Josephin	Josephin	NNP
cord-012045-1cqqj84n	89	44	disease	disease	NN
cord-012045-1cqqj84n	89	45	protein	protein	NN
cord-012045-1cqqj84n	89	46	domain	domain	NN
cord-012045-1cqqj84n	89	47	protease	protease	NN
cord-012045-1cqqj84n	89	48	)	)	-RRB-
cord-012045-1cqqj84n	89	49	[	[	-LRB-
cord-012045-1cqqj84n	89	50	25	25	CD
cord-012045-1cqqj84n	89	51	,	,	,
cord-012045-1cqqj84n	89	52	26	26	CD
cord-012045-1cqqj84n	89	53	]	]	-RRB-
cord-012045-1cqqj84n	89	54	,	,	,
cord-012045-1cqqj84n	89	55	and	and	CC
cord-012045-1cqqj84n	89	56	four	four	CD
cord-012045-1cqqj84n	89	57	members	member	NNS
cord-012045-1cqqj84n	89	58	of	of	IN
cord-012045-1cqqj84n	89	59	MINDYs	mindys	NN
cord-012045-1cqqj84n	89	60	(	(	-LRB-
cord-012045-1cqqj84n	89	61	motif	motif	NN
cord-012045-1cqqj84n	89	62	interacting	interact	VBG
cord-012045-1cqqj84n	89	63	with	with	IN
cord-012045-1cqqj84n	89	64	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	89	65	(	(	-LRB-
cord-012045-1cqqj84n	89	66	MIU)-containing	miu)-containe	VBG
cord-012045-1cqqj84n	89	67	novel	novel	JJ
cord-012045-1cqqj84n	89	68	DUB	DUB	NNP
cord-012045-1cqqj84n	89	69	family	family	NN
cord-012045-1cqqj84n	89	70	)	)	-RRB-
cord-012045-1cqqj84n	89	71	[	[	-LRB-
cord-012045-1cqqj84n	89	72	28	28	CD
cord-012045-1cqqj84n	89	73	]	]	-RRB-
cord-012045-1cqqj84n	89	74	.	.	.
cord-012045-1cqqj84n	90	1	The	the	DT
cord-012045-1cqqj84n	90	2	sixth	sixth	JJ
cord-012045-1cqqj84n	90	3	subfamily	subfamily	NN
cord-012045-1cqqj84n	90	4	is	be	VBZ
cord-012045-1cqqj84n	90	5	JAMMs	jamm	NNS
cord-012045-1cqqj84n	90	6	(	(	-LRB-
cord-012045-1cqqj84n	90	7	Zn	Zn	NNP
cord-012045-1cqqj84n	90	8	-	-	HYPH
cord-012045-1cqqj84n	90	9	JAB1	JAB1	NNP
cord-012045-1cqqj84n	90	10	/	/	SYM
cord-012045-1cqqj84n	90	11	MPN	MPN	NNP
cord-012045-1cqqj84n	90	12	/	/	SYM
cord-012045-1cqqj84n	90	13	MOV34	MOV34	NNP
cord-012045-1cqqj84n	90	14	domain	domain	NN
cord-012045-1cqqj84n	90	15	protease	protease	NN
cord-012045-1cqqj84n	90	16	)	)	-RRB-
cord-012045-1cqqj84n	90	17	,	,	,
cord-012045-1cqqj84n	90	18	which	which	WDT
cord-012045-1cqqj84n	90	19	includes	include	VBZ
cord-012045-1cqqj84n	90	20	a	a	DT
cord-012045-1cqqj84n	90	21	conserved	conserved	JJ
cord-012045-1cqqj84n	90	22	zinc	zinc	NN
cord-012045-1cqqj84n	90	23	metallopeptidase	metallopeptidase	NN
cord-012045-1cqqj84n	90	24	[	[	-LRB-
cord-012045-1cqqj84n	90	25	25	25	CD
cord-012045-1cqqj84n	90	26	,	,	,
cord-012045-1cqqj84n	90	27	26	26	CD
cord-012045-1cqqj84n	90	28	]	]	-RRB-
cord-012045-1cqqj84n	90	29	.	.	.
cord-012045-1cqqj84n	91	1	All	all	DT
cord-012045-1cqqj84n	91	2	DUB	DUB	NNP
cord-012045-1cqqj84n	91	3	family	family	NN
cord-012045-1cqqj84n	91	4	members	member	NNS
cord-012045-1cqqj84n	91	5	bear	bear	VBP
cord-012045-1cqqj84n	91	6	a	a	DT
cord-012045-1cqqj84n	91	7	catalytic	catalytic	JJ
cord-012045-1cqqj84n	91	8	domain	domain	NN
cord-012045-1cqqj84n	91	9	that	that	WDT
cord-012045-1cqqj84n	91	10	removes	remove	VBZ
cord-012045-1cqqj84n	91	11	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	91	12	from	from	IN
cord-012045-1cqqj84n	91	13	the	the	DT
cord-012045-1cqqj84n	91	14	protein	protein	NN
cord-012045-1cqqj84n	91	15	substrates	substrate	NNS
cord-012045-1cqqj84n	91	16	[	[	-LRB-
cord-012045-1cqqj84n	91	17	27	27	CD
cord-012045-1cqqj84n	91	18	]	]	-RRB-
cord-012045-1cqqj84n	91	19	.	.	.
cord-012045-1cqqj84n	92	1	The	the	DT
cord-012045-1cqqj84n	92	2	catalytic	catalytic	JJ
cord-012045-1cqqj84n	92	3	domain	domain	NN
cord-012045-1cqqj84n	92	4	of	of	IN
cord-012045-1cqqj84n	92	5	MIU	MIU	NNP
cord-012045-1cqqj84n	92	6	family	family	NN
cord-012045-1cqqj84n	92	7	sub	sub	NN
cord-012045-1cqqj84n	92	8	-	-	NNS
cord-012045-1cqqj84n	92	9	members	member	NNS
cord-012045-1cqqj84n	92	10	is	be	VBZ
cord-012045-1cqqj84n	92	11	a	a	DT
cord-012045-1cqqj84n	92	12	new	new	JJ
cord-012045-1cqqj84n	92	13	folding	folding	NN
cord-012045-1cqqj84n	92	14	variant	variant	NN
cord-012045-1cqqj84n	92	15	within	within	IN
cord-012045-1cqqj84n	92	16	the	the	DT
cord-012045-1cqqj84n	92	17	superfamily	superfamily	NN
cord-012045-1cqqj84n	92	18	of	of	IN
cord-012045-1cqqj84n	92	19	cysteine	cysteine	JJ
cord-012045-1cqqj84n	92	20	protease	protease	NN
cord-012045-1cqqj84n	92	21	and	and	CC
cord-012045-1cqqj84n	92	22	shows	show	VBZ
cord-012045-1cqqj84n	92	23	a	a	DT
cord-012045-1cqqj84n	92	24	remarkable	remarkable	JJ
cord-012045-1cqqj84n	92	25	selectivity	selectivity	NN
cord-012045-1cqqj84n	92	26	for	for	IN
cord-012045-1cqqj84n	92	27	cleaving	cleave	VBG
cord-012045-1cqqj84n	92	28	long	long	JJ
cord-012045-1cqqj84n	92	29	lysine	lysine	NN
cord-012045-1cqqj84n	92	30	48	48	CD
cord-012045-1cqqj84n	92	31	(	(	-LRB-
cord-012045-1cqqj84n	92	32	K48)-linked	k48)-linked	JJ
cord-012045-1cqqj84n	92	33	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	92	34	chains	chain	NNS
cord-012045-1cqqj84n	92	35	.	.	.
cord-012045-1cqqj84n	93	1	In	in	IN
cord-012045-1cqqj84n	93	2	particular	particular	JJ
cord-012045-1cqqj84n	93	3	,	,	,
cord-012045-1cqqj84n	93	4	cleavage	cleavage	NN
cord-012045-1cqqj84n	93	5	selectivity	selectivity	NN
cord-012045-1cqqj84n	93	6	of	of	IN
cord-012045-1cqqj84n	93	7	DUBs	dub	NNS
cord-012045-1cqqj84n	93	8	is	be	VBZ
cord-012045-1cqqj84n	93	9	determined	determine	VBN
cord-012045-1cqqj84n	93	10	by	by	IN
cord-012045-1cqqj84n	93	11	catalytic	catalytic	JJ
cord-012045-1cqqj84n	93	12	domain	domain	NN
cord-012045-1cqqj84n	93	13	alone	alone	RB
cord-012045-1cqqj84n	93	14	,	,	,
cord-012045-1cqqj84n	93	15	whereas	whereas	IN
cord-012045-1cqqj84n	93	16	a	a	DT
cord-012045-1cqqj84n	93	17	DUB	dub	NN
cord-012045-1cqqj84n	93	18	called	call	VBN
cord-012045-1cqqj84n	93	19	MINDY	MINDY	NNP
cord-012045-1cqqj84n	93	20	requires	require	VBZ
cord-012045-1cqqj84n	93	21	a	a	DT
cord-012045-1cqqj84n	93	22	motif	motif	NN
cord-012045-1cqqj84n	93	23	interacting	interact	VBG
cord-012045-1cqqj84n	93	24	with	with	IN
cord-012045-1cqqj84n	93	25	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	93	26	(	(	-LRB-
cord-012045-1cqqj84n	93	27	MIU	MIU	NNP
cord-012045-1cqqj84n	93	28	)	)	-RRB-
cord-012045-1cqqj84n	93	29	as	as	RB
cord-012045-1cqqj84n	93	30	well	well	RB
cord-012045-1cqqj84n	93	31	as	as	IN
cord-012045-1cqqj84n	93	32	a	a	DT
cord-012045-1cqqj84n	93	33	catalytic	catalytic	JJ
cord-012045-1cqqj84n	93	34	domain	domain	NN
cord-012045-1cqqj84n	93	35	for	for	IN
cord-012045-1cqqj84n	93	36	maximal	maximal	JJ
cord-012045-1cqqj84n	93	37	DUB	dub	NN
cord-012045-1cqqj84n	93	38	activity	activity	NN
cord-012045-1cqqj84n	93	39	[	[	-LRB-
cord-012045-1cqqj84n	93	40	28	28	CD
cord-012045-1cqqj84n	93	41	]	]	-RRB-
cord-012045-1cqqj84n	93	42	.	.	.
cord-012045-1cqqj84n	94	1	The	the	DT
cord-012045-1cqqj84n	94	2	physiological	physiological	JJ
cord-012045-1cqqj84n	94	3	roles	role	NNS
cord-012045-1cqqj84n	94	4	of	of	IN
cord-012045-1cqqj84n	94	5	DUBs	dub	NNS
cord-012045-1cqqj84n	94	6	include	include	VBP
cord-012045-1cqqj84n	94	7	controlling	control	VBG
cord-012045-1cqqj84n	94	8	protein	protein	NN
cord-012045-1cqqj84n	94	9	stability	stability	NN
cord-012045-1cqqj84n	94	10	and	and	CC
cord-012045-1cqqj84n	94	11	quality	quality	NN
cord-012045-1cqqj84n	94	12	,	,	,
cord-012045-1cqqj84n	94	13	maintaining	maintain	VBG
cord-012045-1cqqj84n	94	14	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	94	15	homeostasis	homeostasis	NN
cord-012045-1cqqj84n	94	16	,	,	,
cord-012045-1cqqj84n	94	17	and	and	CC
cord-012045-1cqqj84n	94	18	regulating	regulate	VBG
cord-012045-1cqqj84n	94	19	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	94	20	signals	signal	NNS
cord-012045-1cqqj84n	94	21	against	against	IN
cord-012045-1cqqj84n	94	22	the	the	DT
cord-012045-1cqqj84n	94	23	functions	function	NNS
cord-012045-1cqqj84n	94	24	of	of	IN
cord-012045-1cqqj84n	94	25	E3	e3	NN
cord-012045-1cqqj84n	94	26	Ub	Ub	NNP
cord-012045-1cqqj84n	94	27	ligase	ligase	NN
cord-012045-1cqqj84n	94	28	[	[	-LRB-
cord-012045-1cqqj84n	94	29	23	23	CD
cord-012045-1cqqj84n	94	30	]	]	-RRB-
cord-012045-1cqqj84n	94	31	.	.	.
cord-012045-1cqqj84n	95	1	Therefore	therefore	RB
cord-012045-1cqqj84n	95	2	,	,	,
cord-012045-1cqqj84n	95	3	DUBs	dub	NNS
cord-012045-1cqqj84n	95	4	regulate	regulate	VBP
cord-012045-1cqqj84n	95	5	numerous	numerous	JJ
cord-012045-1cqqj84n	95	6	cellular	cellular	JJ
cord-012045-1cqqj84n	95	7	events	event	NNS
cord-012045-1cqqj84n	95	8	such	such	JJ
cord-012045-1cqqj84n	95	9	as	as	IN
cord-012045-1cqqj84n	95	10	the	the	DT
cord-012045-1cqqj84n	95	11	cell	cell	NN
cord-012045-1cqqj84n	95	12	cycle	cycle	NN
cord-012045-1cqqj84n	95	13	,	,	,
cord-012045-1cqqj84n	95	14	DNA	dna	NN
cord-012045-1cqqj84n	95	15	damage	damage	NN
cord-012045-1cqqj84n	95	16	response	response	NN
cord-012045-1cqqj84n	95	17	,	,	,
cord-012045-1cqqj84n	95	18	inflammatory	inflammatory	JJ
cord-012045-1cqqj84n	95	19	signaling	signaling	NN
cord-012045-1cqqj84n	95	20	,	,	,
cord-012045-1cqqj84n	95	21	and	and	CC
cord-012045-1cqqj84n	95	22	proliferation	proliferation	NN
cord-012045-1cqqj84n	95	23	and	and	CC
cord-012045-1cqqj84n	95	24	cell	cell	NN
cord-012045-1cqqj84n	95	25	death	death	NN
cord-012045-1cqqj84n	95	26	.	.	.
cord-012045-1cqqj84n	96	1	Mounting	mount	VBG
cord-012045-1cqqj84n	96	2	studies	study	NNS
cord-012045-1cqqj84n	96	3	have	have	VBP
cord-012045-1cqqj84n	96	4	focused	focus	VBN
cord-012045-1cqqj84n	96	5	on	on	IN
cord-012045-1cqqj84n	96	6	inflammation	inflammation	NN
cord-012045-1cqqj84n	96	7	to	to	TO
cord-012045-1cqqj84n	96	8	dissect	dissect	VB
cord-012045-1cqqj84n	96	9	its	-PRON-	PRP$
cord-012045-1cqqj84n	96	10	underlying	underlying	JJ
cord-012045-1cqqj84n	96	11	molecular	molecular	JJ
cord-012045-1cqqj84n	96	12	mechanisms	mechanism	NNS
cord-012045-1cqqj84n	96	13	in	in	IN
cord-012045-1cqqj84n	96	14	the	the	DT
cord-012045-1cqqj84n	96	15	pathogenesis	pathogenesis	NN
cord-012045-1cqqj84n	96	16	of	of	IN
cord-012045-1cqqj84n	96	17	ALI	ALI	NNP
cord-012045-1cqqj84n	96	18	/	/	SYM
cord-012045-1cqqj84n	96	19	ARDS	ARDS	NNP
cord-012045-1cqqj84n	96	20	.	.	.
cord-012045-1cqqj84n	97	1	Deubiquitinating	deubiquitinating	NN
cord-012045-1cqqj84n	97	2	enzymes	enzyme	NNS
cord-012045-1cqqj84n	97	3	play	play	VBP
cord-012045-1cqqj84n	97	4	crucial	crucial	JJ
cord-012045-1cqqj84n	97	5	roles	role	NNS
cord-012045-1cqqj84n	97	6	in	in	IN
cord-012045-1cqqj84n	97	7	modulation	modulation	NN
cord-012045-1cqqj84n	97	8	of	of	IN
cord-012045-1cqqj84n	97	9	inflammation	inflammation	NN
cord-012045-1cqqj84n	97	10	by	by	IN
cord-012045-1cqqj84n	97	11	changing	change	VBG
cord-012045-1cqqj84n	97	12	the	the	DT
cord-012045-1cqqj84n	97	13	protein	protein	NN
cord-012045-1cqqj84n	97	14	stability	stability	NN
cord-012045-1cqqj84n	97	15	of	of	IN
cord-012045-1cqqj84n	97	16	the	the	DT
cord-012045-1cqqj84n	97	17	critical	critical	JJ
cord-012045-1cqqj84n	97	18	molecules	molecule	NNS
cord-012045-1cqqj84n	97	19	(	(	-LRB-
cord-012045-1cqqj84n	97	20	Table	Table	NNP
cord-012045-1cqqj84n	97	21	1	1	CD
cord-012045-1cqqj84n	97	22	)	)	-RRB-
cord-012045-1cqqj84n	97	23	.	.	.
cord-012045-1cqqj84n	98	1	Several	several	JJ
cord-012045-1cqqj84n	98	2	USPs	usp	NNS
cord-012045-1cqqj84n	98	3	have	have	VBP
cord-012045-1cqqj84n	98	4	proved	prove	VBN
cord-012045-1cqqj84n	98	5	to	to	TO
cord-012045-1cqqj84n	98	6	play	play	VB
cord-012045-1cqqj84n	98	7	emerging	emerge	VBG
cord-012045-1cqqj84n	98	8	roles	role	NNS
cord-012045-1cqqj84n	98	9	in	in	IN
cord-012045-1cqqj84n	98	10	the	the	DT
cord-012045-1cqqj84n	98	11	regulation	regulation	NN
cord-012045-1cqqj84n	98	12	of	of	IN
cord-012045-1cqqj84n	98	13	lung	lung	NN
cord-012045-1cqqj84n	98	14	inflammation	inflammation	NN
cord-012045-1cqqj84n	98	15	[	[	-LRB-
cord-012045-1cqqj84n	98	16	29	29	CD
cord-012045-1cqqj84n	98	17	,	,	,
cord-012045-1cqqj84n	98	18	30	30	CD
cord-012045-1cqqj84n	98	19	]	]	-RRB-
cord-012045-1cqqj84n	98	20	.	.	.
cord-012045-1cqqj84n	99	1	Innate	innate	JJ
cord-012045-1cqqj84n	99	2	immunity	immunity	NN
cord-012045-1cqqj84n	99	3	provides	provide	VBZ
cord-012045-1cqqj84n	99	4	the	the	DT
cord-012045-1cqqj84n	99	5	first	first	JJ
cord-012045-1cqqj84n	99	6	line	line	NN
cord-012045-1cqqj84n	99	7	of	of	IN
cord-012045-1cqqj84n	99	8	host	host	NN
cord-012045-1cqqj84n	99	9	defense	defense	NN
cord-012045-1cqqj84n	99	10	against	against	IN
cord-012045-1cqqj84n	99	11	pathogens	pathogen	NNS
cord-012045-1cqqj84n	99	12	.	.	.
cord-012045-1cqqj84n	100	1	In	in	IN
cord-012045-1cqqj84n	100	2	lung	lung	NN
cord-012045-1cqqj84n	100	3	inflammation	inflammation	NN
cord-012045-1cqqj84n	100	4	,	,	,
cord-012045-1cqqj84n	100	5	USP14	usp14	JJ
cord-012045-1cqqj84n	100	6	protein	protein	NN
cord-012045-1cqqj84n	100	7	is	be	VBZ
cord-012045-1cqqj84n	100	8	over	over	RB
cord-012045-1cqqj84n	100	9	-	-	HYPH
cord-012045-1cqqj84n	100	10	expressed	express	VBN
cord-012045-1cqqj84n	100	11	,	,	,
cord-012045-1cqqj84n	100	12	reducing	reduce	VBG
cord-012045-1cqqj84n	100	13	I	I	NNP
cord-012045-1cqqj84n	100	14	-	-	HYPH
cord-012045-1cqqj84n	100	15	κB	κB	NNP
cord-012045-1cqqj84n	100	16	protein	protein	NN
cord-012045-1cqqj84n	100	17	levels	level	NNS
cord-012045-1cqqj84n	100	18	and	and	CC
cord-012045-1cqqj84n	100	19	thus	thus	RB
cord-012045-1cqqj84n	100	20	increasing	increase	VBG
cord-012045-1cqqj84n	100	21	cytokine	cytokine	NN
cord-012045-1cqqj84n	100	22	release	release	NN
cord-012045-1cqqj84n	100	23	in	in	IN
cord-012045-1cqqj84n	100	24	lung	lung	NN
cord-012045-1cqqj84n	100	25	epithelial	epithelial	JJ
cord-012045-1cqqj84n	100	26	cells	cell	NNS
cord-012045-1cqqj84n	100	27	[	[	-LRB-
cord-012045-1cqqj84n	100	28	31	31	CD
cord-012045-1cqqj84n	100	29	,	,	,
cord-012045-1cqqj84n	100	30	32	32	CD
cord-012045-1cqqj84n	100	31	]	]	-RRB-
cord-012045-1cqqj84n	100	32	.	.	.
cord-012045-1cqqj84n	101	1	USP7	USP7	NNP
cord-012045-1cqqj84n	101	2	acts	act	VBZ
cord-012045-1cqqj84n	101	3	as	as	IN
cord-012045-1cqqj84n	101	4	a	a	DT
cord-012045-1cqqj84n	101	5	negative	negative	JJ
cord-012045-1cqqj84n	101	6	regulator	regulator	NN
cord-012045-1cqqj84n	101	7	of	of	IN
cord-012045-1cqqj84n	101	8	the	the	DT
cord-012045-1cqqj84n	101	9	NF	nf	NN
cord-012045-1cqqj84n	101	10	-	-	HYPH
cord-012045-1cqqj84n	101	11	κB	κB	NNP
cord-012045-1cqqj84n	101	12	pathway	pathway	NN
cord-012045-1cqqj84n	101	13	by	by	IN
cord-012045-1cqqj84n	101	14	mediating	mediate	VBG
cord-012045-1cqqj84n	101	15	the	the	DT
cord-012045-1cqqj84n	101	16	deubiquitination	deubiquitination	NN
cord-012045-1cqqj84n	101	17	of	of	IN
cord-012045-1cqqj84n	101	18	NEMO	NEMO	NNP
cord-012045-1cqqj84n	101	19	,	,	,
cord-012045-1cqqj84n	101	20	TRAF6	TRAF6	NNP
cord-012045-1cqqj84n	101	21	and	and	CC
cord-012045-1cqqj84n	101	22	IKKγ	IKKγ	NNPS
cord-012045-1cqqj84n	101	23	,	,	,
cord-012045-1cqqj84n	101	24	which	which	WDT
cord-012045-1cqqj84n	101	25	leads	lead	VBZ
cord-012045-1cqqj84n	101	26	to	to	IN
cord-012045-1cqqj84n	101	27	the	the	DT
cord-012045-1cqqj84n	101	28	retention	retention	NN
cord-012045-1cqqj84n	101	29	of	of	IN
cord-012045-1cqqj84n	101	30	NF	NF	NNP
cord-012045-1cqqj84n	101	31	-	-	HYPH
cord-012045-1cqqj84n	101	32	κB	κB	NNP
cord-012045-1cqqj84n	101	33	in	in	IN
cord-012045-1cqqj84n	101	34	the	the	DT
cord-012045-1cqqj84n	101	35	cytosol	cytosol	NN
cord-012045-1cqqj84n	101	36	,	,	,
cord-012045-1cqqj84n	101	37	thus	thus	RB
cord-012045-1cqqj84n	101	38	suppressing	suppress	VBG
cord-012045-1cqqj84n	101	39	its	-PRON-	PRP$
cord-012045-1cqqj84n	101	40	activity	activity	NN
cord-012045-1cqqj84n	101	41	[	[	-LRB-
cord-012045-1cqqj84n	101	42	33	33	CD
cord-012045-1cqqj84n	101	43	,	,	,
cord-012045-1cqqj84n	101	44	34	34	CD
cord-012045-1cqqj84n	101	45	]	]	-RRB-
cord-012045-1cqqj84n	101	46	.	.	.
cord-012045-1cqqj84n	102	1	Pro	pro	JJ
cord-012045-1cqqj84n	102	2	and	and	CC
cord-012045-1cqqj84n	102	3	anti	anti	JJ
cord-012045-1cqqj84n	102	4	-	-	JJ
cord-012045-1cqqj84n	102	5	inflammatory	inflammatory	JJ
cord-012045-1cqqj84n	102	6	cytokines	cytokine	NNS
cord-012045-1cqqj84n	102	7	increase	increase	NN
cord-012045-1cqqj84n	102	8	in	in	IN
cord-012045-1cqqj84n	102	9	bronchoalveolar	bronchoalveolar	NNP
cord-012045-1cqqj84n	102	10	lavage	lavage	NN
cord-012045-1cqqj84n	102	11	fluid	fluid	NN
cord-012045-1cqqj84n	102	12	and	and	CC
cord-012045-1cqqj84n	102	13	circulating	circulate	VBG
cord-012045-1cqqj84n	102	14	plasma	plasma	NN
cord-012045-1cqqj84n	102	15	of	of	IN
cord-012045-1cqqj84n	102	16	patients	patient	NNS
cord-012045-1cqqj84n	102	17	at	at	IN
cord-012045-1cqqj84n	102	18	different	different	JJ
cord-012045-1cqqj84n	102	19	stages	stage	NNS
cord-012045-1cqqj84n	102	20	of	of	IN
cord-012045-1cqqj84n	102	21	ARDS	ARDS	NNP
cord-012045-1cqqj84n	102	22	.	.	.
cord-012045-1cqqj84n	103	1	TNF	TNF	NNP
cord-012045-1cqqj84n	103	2	-	-	HYPH
cord-012045-1cqqj84n	103	3	α	α	NNP
cord-012045-1cqqj84n	103	4	and	and	CC
cord-012045-1cqqj84n	103	5	IL-1β	IL-1β	NNP
cord-012045-1cqqj84n	103	6	are	be	VBP
cord-012045-1cqqj84n	103	7	important	important	JJ
cord-012045-1cqqj84n	103	8	proinflammatory	proinflammatory	JJ
cord-012045-1cqqj84n	103	9	cytokines	cytokine	NNS
cord-012045-1cqqj84n	103	10	in	in	IN
cord-012045-1cqqj84n	103	11	the	the	DT
cord-012045-1cqqj84n	103	12	pathogenesis	pathogenesis	NN
cord-012045-1cqqj84n	103	13	of	of	IN
cord-012045-1cqqj84n	103	14	ARDS	ARDS	NNP
cord-012045-1cqqj84n	103	15	[	[	-LRB-
cord-012045-1cqqj84n	103	16	35	35	CD
cord-012045-1cqqj84n	103	17	]	]	-RRB-
cord-012045-1cqqj84n	103	18	.	.	.
cord-012045-1cqqj84n	104	1	After	after	IN
cord-012045-1cqqj84n	104	2	their	-PRON-	PRP$
cord-012045-1cqqj84n	104	3	receptor	receptor	NN
cord-012045-1cqqj84n	104	4	activation	activation	NN
cord-012045-1cqqj84n	104	5	,	,	,
cord-012045-1cqqj84n	104	6	cIAP	ciap	NN
cord-012045-1cqqj84n	104	7	-	-	HYPH
cord-012045-1cqqj84n	104	8	mediated	mediate	VBN
cord-012045-1cqqj84n	104	9	K63-ubiquitination	K63-ubiquitination	NNP
cord-012045-1cqqj84n	104	10	of	of	IN
cord-012045-1cqqj84n	104	11	RIPK1	RIPK1	NNP
cord-012045-1cqqj84n	104	12	and	and	CC
cord-012045-1cqqj84n	104	13	the	the	DT
cord-012045-1cqqj84n	104	14	TRAF	TRAF	NNP
cord-012045-1cqqj84n	104	15	proteins	protein	NNS
cord-012045-1cqqj84n	104	16	leads	lead	VBZ
cord-012045-1cqqj84n	104	17	to	to	IN
cord-012045-1cqqj84n	104	18	the	the	DT
cord-012045-1cqqj84n	104	19	recruitment	recruitment	NN
cord-012045-1cqqj84n	104	20	of	of	IN
cord-012045-1cqqj84n	104	21	linear	linear	JJ
cord-012045-1cqqj84n	104	22	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	104	23	chain	chain	NN
cord-012045-1cqqj84n	104	24	assembly	assembly	NN
cord-012045-1cqqj84n	104	25	complex	complex	NN
cord-012045-1cqqj84n	104	26	(	(	-LRB-
cord-012045-1cqqj84n	104	27	LUBAC	LUBAC	NNP
cord-012045-1cqqj84n	104	28	)	)	-RRB-
cord-012045-1cqqj84n	104	29	.	.	.
cord-012045-1cqqj84n	105	1	The	the	DT
cord-012045-1cqqj84n	105	2	stability	stability	NN
cord-012045-1cqqj84n	105	3	of	of	IN
cord-012045-1cqqj84n	105	4	lysophosphatidic	lysophosphatidic	NNP
cord-012045-1cqqj84n	105	5	acid	acid	NNP
cord-012045-1cqqj84n	105	6	receptor	receptor	NN
cord-012045-1cqqj84n	105	7	1	1	CD
cord-012045-1cqqj84n	105	8	(	(	-LRB-
cord-012045-1cqqj84n	105	9	LPA1	LPA1	NNP
cord-012045-1cqqj84n	105	10	)	)	-RRB-
cord-012045-1cqqj84n	105	11	is	be	VBZ
cord-012045-1cqqj84n	105	12	up	up	RB
cord-012045-1cqqj84n	105	13	-	-	HYPH
cord-012045-1cqqj84n	105	14	regulated	regulate	VBN
cord-012045-1cqqj84n	105	15	by	by	IN
cord-012045-1cqqj84n	105	16	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	105	17	-	-	HYPH
cord-012045-1cqqj84n	105	18	specific	specific	JJ
cord-012045-1cqqj84n	105	19	protease	protease	NN
cord-012045-1cqqj84n	105	20	11	11	CD
cord-012045-1cqqj84n	105	21	(	(	-LRB-
cord-012045-1cqqj84n	105	22	USP11	USP11	NNP
cord-012045-1cqqj84n	105	23	)	)	-RRB-
cord-012045-1cqqj84n	105	24	,	,	,
cord-012045-1cqqj84n	105	25	which	which	WDT
cord-012045-1cqqj84n	105	26	deubiquitinates	deubiquitinate	VBZ
cord-012045-1cqqj84n	105	27	LPA1	LPA1	NNP
cord-012045-1cqqj84n	105	28	and	and	CC
cord-012045-1cqqj84n	105	29	enhances	enhance	VBZ
cord-012045-1cqqj84n	105	30	LPA1-mediated	lpa1-mediate	VBN
cord-012045-1cqqj84n	105	31	proinflammatory	proinflammatory	JJ
cord-012045-1cqqj84n	105	32	effects	effect	NNS
cord-012045-1cqqj84n	105	33	[	[	-LRB-
cord-012045-1cqqj84n	105	34	33	33	CD
cord-012045-1cqqj84n	105	35	,	,	,
cord-012045-1cqqj84n	105	36	[	[	-LRB-
cord-012045-1cqqj84n	105	37	36	36	CD
cord-012045-1cqqj84n	105	38	]	]	-RRB-
cord-012045-1cqqj84n	106	1	[	[	-LRB-
cord-012045-1cqqj84n	106	2	37	37	CD
cord-012045-1cqqj84n	106	3	]	]	-RRB-
cord-012045-1cqqj84n	106	4	[	[	-LRB-
cord-012045-1cqqj84n	106	5	38	38	CD
cord-012045-1cqqj84n	106	6	]	]	-RRB-
cord-012045-1cqqj84n	106	7	[	[	-LRB-
cord-012045-1cqqj84n	106	8	39	39	CD
cord-012045-1cqqj84n	106	9	]	]	-RRB-
cord-012045-1cqqj84n	106	10	.	.	.
cord-012045-1cqqj84n	107	1	Furthermore	furthermore	RB
cord-012045-1cqqj84n	107	2	,	,	,
cord-012045-1cqqj84n	107	3	the	the	DT
cord-012045-1cqqj84n	107	4	deubiquitinating	deubiquitinating	NN
cord-012045-1cqqj84n	107	5	enzyme	enzyme	NN
cord-012045-1cqqj84n	107	6	USP13	USP13	NNP
cord-012045-1cqqj84n	107	7	stabilizes	stabilize	VBZ
cord-012045-1cqqj84n	107	8	the	the	DT
cord-012045-1cqqj84n	107	9	anti	anti	JJ
cord-012045-1cqqj84n	107	10	-	-	JJ
cord-012045-1cqqj84n	107	11	inflammatory	inflammatory	JJ
cord-012045-1cqqj84n	107	12	receptor	receptor	NN
cord-012045-1cqqj84n	107	13	IL-1R8	il-1r8	NN
cord-012045-1cqqj84n	107	14	/	/	,
cord-012045-1cqqj84n	107	15	Sigirr	Sigirr	NNP
cord-012045-1cqqj84n	107	16	to	to	TO
cord-012045-1cqqj84n	107	17	suppress	suppress	VB
cord-012045-1cqqj84n	107	18	lung	lung	NN
cord-012045-1cqqj84n	107	19	inflammation	inflammation	NN
cord-012045-1cqqj84n	107	20	[	[	-LRB-
cord-012045-1cqqj84n	107	21	40	40	CD
cord-012045-1cqqj84n	107	22	]	]	-RRB-
cord-012045-1cqqj84n	108	1	[	[	-LRB-
cord-012045-1cqqj84n	108	2	41	41	CD
cord-012045-1cqqj84n	108	3	]	]	-RRB-
cord-012045-1cqqj84n	108	4	[	[	-LRB-
cord-012045-1cqqj84n	108	5	42	42	CD
cord-012045-1cqqj84n	108	6	]	]	-RRB-
cord-012045-1cqqj84n	108	7	.	.	.
cord-012045-1cqqj84n	109	1	[	[	-LRB-
cord-012045-1cqqj84n	109	2	45	45	CD
cord-012045-1cqqj84n	109	3	,	,	,
cord-012045-1cqqj84n	109	4	46	46	CD
cord-012045-1cqqj84n	109	5	]	]	-RRB-
cord-012045-1cqqj84n	109	6	Regulates	regulate	VBZ
cord-012045-1cqqj84n	109	7	TLR4	tlr4	XX
cord-012045-1cqqj84n	110	1	signaling	signal	VBG
cord-012045-1cqqj84n	111	1	[	[	-LRB-
cord-012045-1cqqj84n	111	2	45	45	CD
cord-012045-1cqqj84n	111	3	]	]	-RRB-
cord-012045-1cqqj84n	111	4	Inhibits	inhibit	VBZ
cord-012045-1cqqj84n	111	5	inflammation	inflammation	NN
cord-012045-1cqqj84n	111	6	[	[	-LRB-
cord-012045-1cqqj84n	111	7	46	46	CD
cord-012045-1cqqj84n	111	8	]	]	-RRB-
cord-012045-1cqqj84n	112	1	AKT	AKT	NNP
cord-012045-1cqqj84n	112	2	[	[	-LRB-
cord-012045-1cqqj84n	112	3	47	47	CD
cord-012045-1cqqj84n	112	4	]	]	-RRB-
cord-012045-1cqqj84n	112	5	Regulates	regulate	NNS
cord-012045-1cqqj84n	113	1	TGF	TGF	NNP
cord-012045-1cqqj84n	113	2	-	-	HYPH
cord-012045-1cqqj84n	113	3	β	β	NN
cord-012045-1cqqj84n	113	4	signaling	signal	VBG
cord-012045-1cqqj84n	113	5	[	[	-LRB-
cord-012045-1cqqj84n	113	6	47	47	CD
cord-012045-1cqqj84n	113	7	]	]	-RRB-
cord-012045-1cqqj84n	113	8	PAI-1	PAI-1	NNP
cord-012045-1cqqj84n	113	9	[	[	-LRB-
cord-012045-1cqqj84n	113	10	48	48	CD
cord-012045-1cqqj84n	113	11	]	]	-RRB-
cord-012045-1cqqj84n	114	1	Regulates	regulate	VBZ
cord-012045-1cqqj84n	114	2	acute	acute	JJ
cord-012045-1cqqj84n	114	3	lung	lung	NN
cord-012045-1cqqj84n	114	4	injury	injury	NN
cord-012045-1cqqj84n	114	5	[	[	-LRB-
cord-012045-1cqqj84n	114	6	48	48	CD
cord-012045-1cqqj84n	114	7	]	]	-RRB-
cord-012045-1cqqj84n	115	1	USP-7	USP-7	NNP
cord-012045-1cqqj84n	116	1	NLRP3	NLRP3	NNP
cord-012045-1cqqj84n	117	1	[	[	-LRB-
cord-012045-1cqqj84n	117	2	38	38	CD
cord-012045-1cqqj84n	117	3	]	]	-RRB-
cord-012045-1cqqj84n	117	4	Regulates	regulate	VBZ
cord-012045-1cqqj84n	117	5	NLRP3	nlrp3	NN
cord-012045-1cqqj84n	117	6	inflammasome	inflammasome	NN
cord-012045-1cqqj84n	117	7	activation	activation	NN
cord-012045-1cqqj84n	117	8	[	[	-LRB-
cord-012045-1cqqj84n	117	9	38	38	CD
cord-012045-1cqqj84n	117	10	]	]	-RRB-
cord-012045-1cqqj84n	118	1	NF	nf	NN
cord-012045-1cqqj84n	118	2	-	-	HYPH
cord-012045-1cqqj84n	118	3	κB	κB	NNP
cord-012045-1cqqj84n	119	1	[	[	-LRB-
cord-012045-1cqqj84n	119	2	39	39	CD
cord-012045-1cqqj84n	119	3	]	]	-RRB-
cord-012045-1cqqj84n	119	4	,	,	,
cord-012045-1cqqj84n	119	5	NEMO	NEMO	NNP
cord-012045-1cqqj84n	119	6	[	[	-LRB-
cord-012045-1cqqj84n	119	7	33	33	CD
cord-012045-1cqqj84n	119	8	]	]	-RRB-
cord-012045-1cqqj84n	119	9	Regulates	regulate	NNS
cord-012045-1cqqj84n	120	1	NF	NF	NNP
cord-012045-1cqqj84n	120	2	-	-	HYPH
cord-012045-1cqqj84n	120	3	κB	κB	NNP
cord-012045-1cqqj84n	120	4	signaling	signal	VBG
cord-012045-1cqqj84n	120	5	[	[	-LRB-
cord-012045-1cqqj84n	120	6	33	33	CD
cord-012045-1cqqj84n	120	7	,	,	,
cord-012045-1cqqj84n	120	8	39	39	CD
cord-012045-1cqqj84n	120	9	]	]	-RRB-
cord-012045-1cqqj84n	121	1	VP24	VP24	NNP
cord-012045-1cqqj84n	121	2	[	[	-LRB-
cord-012045-1cqqj84n	121	3	49	49	CD
cord-012045-1cqqj84n	121	4	]	]	-RRB-
cord-012045-1cqqj84n	121	5	Involves	involve	VBZ
cord-012045-1cqqj84n	121	6	in	in	IN
cord-012045-1cqqj84n	121	7	virus	virus	NN
cord-012045-1cqqj84n	121	8	replication	replication	NN
cord-012045-1cqqj84n	121	9	[	[	-LRB-
cord-012045-1cqqj84n	121	10	49	49	CD
cord-012045-1cqqj84n	121	11	]	]	-RRB-
cord-012045-1cqqj84n	122	1	Tat	Tat	NNP
cord-012045-1cqqj84n	122	2	[	[	-LRB-
cord-012045-1cqqj84n	122	3	50	50	CD
cord-012045-1cqqj84n	122	4	]	]	-RRB-
cord-012045-1cqqj84n	122	5	Involves	involve	VBZ
cord-012045-1cqqj84n	122	6	in	in	IN
cord-012045-1cqqj84n	122	7	virus	virus	NN
cord-012045-1cqqj84n	122	8	production	production	NN
cord-012045-1cqqj84n	122	9	[	[	-LRB-
cord-012045-1cqqj84n	122	10	50	50	CD
cord-012045-1cqqj84n	122	11	]	]	-RRB-
cord-012045-1cqqj84n	123	1	TRAF3	TRAF3	NNP
cord-012045-1cqqj84n	124	1	/TRAF6	/TRAF6	.
cord-012045-1cqqj84n	125	1	[	[	-LRB-
cord-012045-1cqqj84n	125	2	51	51	CD
cord-012045-1cqqj84n	125	3	]	]	-RRB-
cord-012045-1cqqj84n	125	4	Modulates	modulate	VBZ
cord-012045-1cqqj84n	125	5	antiviral	antiviral	JJ
cord-012045-1cqqj84n	125	6	signaling	signal	VBG
cord-012045-1cqqj84n	126	1	[	[	-LRB-
cord-012045-1cqqj84n	126	2	51	51	CD
cord-012045-1cqqj84n	126	3	]	]	-RRB-
cord-012045-1cqqj84n	126	4	TRAF6	TRAF6	NNP
cord-012045-1cqqj84n	126	5	/	/	SYM
cord-012045-1cqqj84n	126	6	IKKγ	IKKγ	NNS
cord-012045-1cqqj84n	126	7	[	[	-LRB-
cord-012045-1cqqj84n	126	8	34	34	CD
cord-012045-1cqqj84n	126	9	]	]	-RRB-
cord-012045-1cqqj84n	126	10	Regulates	regulate	VBZ
cord-012045-1cqqj84n	126	11	TLR	TLR	NNP
cord-012045-1cqqj84n	126	12	signaling	signal	VBG
cord-012045-1cqqj84n	127	1	[	[	-LRB-
cord-012045-1cqqj84n	127	2	34	34	CD
cord-012045-1cqqj84n	127	3	]	]	-RRB-
cord-012045-1cqqj84n	127	4	USP-10	USP-10	``
cord-012045-1cqqj84n	127	5	CFTR	CFTR	NNP
cord-012045-1cqqj84n	127	6	[	[	-LRB-
cord-012045-1cqqj84n	127	7	37	37	CD
cord-012045-1cqqj84n	127	8	,	,	,
cord-012045-1cqqj84n	127	9	52	52	CD
cord-012045-1cqqj84n	127	10	]	]	-RRB-
cord-012045-1cqqj84n	127	11	Epithelial	epithelial	JJ
cord-012045-1cqqj84n	127	12	mucosal	mucosal	JJ
cord-012045-1cqqj84n	127	13	clearance	clearance	NN
cord-012045-1cqqj84n	127	14	[	[	-LRB-
cord-012045-1cqqj84n	127	15	37,52	37,52	CD
cord-012045-1cqqj84n	127	16	]	]	-RRB-
cord-012045-1cqqj84n	127	17	NICD1	NICD1	.
cord-012045-1cqqj84n	128	1	[	[	-LRB-
cord-012045-1cqqj84n	128	2	53	53	CD
cord-012045-1cqqj84n	128	3	]	]	-RRB-
cord-012045-1cqqj84n	128	4	Regulates	regulate	VBZ
cord-012045-1cqqj84n	128	5	Notch	notch	NN
cord-012045-1cqqj84n	128	6	signaling	signal	VBG
cord-012045-1cqqj84n	129	1	[	[	-LRB-
cord-012045-1cqqj84n	129	2	53	53	CD
cord-012045-1cqqj84n	129	3	]	]	-RRB-
cord-012045-1cqqj84n	129	4	USP-11	USP-11	NNP
cord-012045-1cqqj84n	129	5	E2F1	E2F1	NNP
cord-012045-1cqqj84n	129	6	[	[	-LRB-
cord-012045-1cqqj84n	129	7	54	54	CD
cord-012045-1cqqj84n	129	8	]	]	-RRB-
cord-012045-1cqqj84n	129	9	Regulates	regulate	NNS
cord-012045-1cqqj84n	129	10	lung	lung	NN
cord-012045-1cqqj84n	129	11	epithelia	epithelia	VBP
cord-012045-1cqqj84n	129	12	proliferation	proliferation	NN
cord-012045-1cqqj84n	129	13	and	and	CC
cord-012045-1cqqj84n	129	14	wound	wind	VBN
cord-012045-1cqqj84n	129	15	healing	healing	NN
cord-012045-1cqqj84n	130	1	[	[	-LRB-
cord-012045-1cqqj84n	130	2	54	54	CD
cord-012045-1cqqj84n	130	3	]	]	-RRB-
cord-012045-1cqqj84n	130	4	LPA1	LPA1	NNP
cord-012045-1cqqj84n	130	5	[	[	-LRB-
cord-012045-1cqqj84n	130	6	36	36	CD
cord-012045-1cqqj84n	130	7	]	]	-RRB-
cord-012045-1cqqj84n	130	8	Enhances	enhance	VBZ
cord-012045-1cqqj84n	130	9	inflammation	inflammation	NN
cord-012045-1cqqj84n	130	10	[	[	-LRB-
cord-012045-1cqqj84n	130	11	36	36	CD
cord-012045-1cqqj84n	130	12	]	]	-RRB-
cord-012045-1cqqj84n	130	13	USP-13	USP-13	NNP
cord-012045-1cqqj84n	130	14	IL-1R8	il-1r8	NN
cord-012045-1cqqj84n	130	15	/	/	,
cord-012045-1cqqj84n	130	16	Sigirr	Sigirr	NNP
cord-012045-1cqqj84n	130	17	[	[	-LRB-
cord-012045-1cqqj84n	130	18	40	40	CD
cord-012045-1cqqj84n	130	19	]	]	-RRB-
cord-012045-1cqqj84n	131	1	Suppresses	suppress	VBZ
cord-012045-1cqqj84n	131	2	lung	lung	NN
cord-012045-1cqqj84n	131	3	inflammation	inflammation	NN
cord-012045-1cqqj84n	131	4	[	[	-LRB-
cord-012045-1cqqj84n	131	5	40	40	CD
cord-012045-1cqqj84n	131	6	]	]	-RRB-
cord-012045-1cqqj84n	132	1	PTEN	PTEN	NNP
cord-012045-1cqqj84n	132	2	[	[	-LRB-
cord-012045-1cqqj84n	132	3	41	41	CD
cord-012045-1cqqj84n	132	4	]	]	-RRB-
cord-012045-1cqqj84n	132	5	Regulates	regulate	NNS
cord-012045-1cqqj84n	132	6	cell	cell	NN
cord-012045-1cqqj84n	132	7	apoptosis	apoptosis	NN
cord-012045-1cqqj84n	132	8	[	[	-LRB-
cord-012045-1cqqj84n	132	9	41	41	CD
cord-012045-1cqqj84n	132	10	]	]	-RRB-
cord-012045-1cqqj84n	132	11	MCL1	MCL1	NNP
cord-012045-1cqqj84n	132	12	[	[	-LRB-
cord-012045-1cqqj84n	132	13	42	42	CD
cord-012045-1cqqj84n	132	14	]	]	-RRB-
cord-012045-1cqqj84n	132	15	Regulates	regulate	VBZ
cord-012045-1cqqj84n	132	16	transformation	transformation	NN
cord-012045-1cqqj84n	132	17	of	of	IN
cord-012045-1cqqj84n	132	18	fibroblasts	fibroblast	NNS
cord-012045-1cqqj84n	132	19	[	[	-LRB-
cord-012045-1cqqj84n	132	20	42	42	CD
cord-012045-1cqqj84n	132	21	]	]	-RRB-
cord-012045-1cqqj84n	133	1	STAT1	stat1	XX
cord-012045-1cqqj84n	134	1	[	[	-LRB-
cord-012045-1cqqj84n	134	2	55	55	CD
cord-012045-1cqqj84n	134	3	]	]	-RRB-
cord-012045-1cqqj84n	134	4	Regulates	regulate	VBZ
cord-012045-1cqqj84n	134	5	IFN	IFN	NNP
cord-012045-1cqqj84n	134	6	Signaling	signal	VBG
cord-012045-1cqqj84n	134	7	[	[	-LRB-
cord-012045-1cqqj84n	134	8	55	55	CD
cord-012045-1cqqj84n	134	9	]	]	-RRB-
cord-012045-1cqqj84n	134	10	STING	sting	VB
cord-012045-1cqqj84n	134	11	[	[	-LRB-
cord-012045-1cqqj84n	134	12	56	56	CD
cord-012045-1cqqj84n	134	13	]	]	-RRB-
cord-012045-1cqqj84n	135	1	Negatively	negatively	RB
cord-012045-1cqqj84n	135	2	regulates	regulate	VBZ
cord-012045-1cqqj84n	135	3	antiviral	antiviral	JJ
cord-012045-1cqqj84n	135	4	responses	response	NNS
cord-012045-1cqqj84n	135	5	[	[	-LRB-
cord-012045-1cqqj84n	135	6	56	56	CD
cord-012045-1cqqj84n	135	7	]	]	-RRB-
cord-012045-1cqqj84n	135	8	USP-14	USP-14	NNP
cord-012045-1cqqj84n	135	9	I	I	NNP
cord-012045-1cqqj84n	135	10	-	-	HYPH
cord-012045-1cqqj84n	135	11	kB	kB	NNP
cord-012045-1cqqj84n	136	1	[	[	-LRB-
cord-012045-1cqqj84n	136	2	31	31	CD
cord-012045-1cqqj84n	136	3	]	]	-RRB-
cord-012045-1cqqj84n	136	4	Increases	increase	NNS
cord-012045-1cqqj84n	136	5	cytokine	cytokine	NN
cord-012045-1cqqj84n	136	6	release	release	NN
cord-012045-1cqqj84n	136	7	[	[	-LRB-
cord-012045-1cqqj84n	136	8	31	31	CD
cord-012045-1cqqj84n	136	9	]	]	-RRB-
cord-012045-1cqqj84n	136	10	CBP	CBP	NNP
cord-012045-1cqqj84n	136	11	[	[	-LRB-
cord-012045-1cqqj84n	136	12	32	32	CD
cord-012045-1cqqj84n	136	13	]	]	-RRB-
cord-012045-1cqqj84n	137	1	Lung	lung	NN
cord-012045-1cqqj84n	137	2	inflammation	inflammation	NN
cord-012045-1cqqj84n	137	3	[	[	-LRB-
cord-012045-1cqqj84n	137	4	32	32	CD
cord-012045-1cqqj84n	137	5	]	]	-RRB-
cord-012045-1cqqj84n	138	1	USP-15	USP-15	NNP
cord-012045-1cqqj84n	138	2	IκBα	IκBα	NNP
cord-012045-1cqqj84n	138	3	[	[	-LRB-
cord-012045-1cqqj84n	138	4	57	57	CD
cord-012045-1cqqj84n	138	5	]	]	-RRB-
cord-012045-1cqqj84n	138	6	NF	NF	NNP
cord-012045-1cqqj84n	138	7	-	-	HYPH
cord-012045-1cqqj84n	138	8	κB	κb	CD
cord-012045-1cqqj84n	138	9	activation	activation	NN
cord-012045-1cqqj84n	138	10	[	[	-LRB-
cord-012045-1cqqj84n	138	11	57	57	CD
cord-012045-1cqqj84n	138	12	]	]	-RRB-
cord-012045-1cqqj84n	139	1	USP-17	USP-17	NNP
cord-012045-1cqqj84n	139	2	HDAC2	HDAC2	NNP
cord-012045-1cqqj84n	140	1	[	[	-LRB-
cord-012045-1cqqj84n	140	2	58	58	CD
cord-012045-1cqqj84n	140	3	]	]	-RRB-
cord-012045-1cqqj84n	140	4	Reverses	reverse	VBZ
cord-012045-1cqqj84n	140	5	glucocorticoid	glucocorticoid	NN
cord-012045-1cqqj84n	140	6	resistance	resistance	NN
cord-012045-1cqqj84n	140	7	[	[	-LRB-
cord-012045-1cqqj84n	140	8	58	58	CD
cord-012045-1cqqj84n	140	9	]	]	-RRB-
cord-012045-1cqqj84n	141	1	TRAF2/	TRAF2/	NNP
cord-012045-1cqqj84n	142	1	TRAF3	TRAF3	NNP
cord-012045-1cqqj84n	143	1	[	[	-LRB-
cord-012045-1cqqj84n	143	2	59	59	CD
cord-012045-1cqqj84n	143	3	]	]	-RRB-
cord-012045-1cqqj84n	143	4	Lung	lung	NN
cord-012045-1cqqj84n	143	5	inflammation	inflammation	NN
cord-012045-1cqqj84n	143	6	[	[	-LRB-
cord-012045-1cqqj84n	143	7	59	59	CD
cord-012045-1cqqj84n	143	8	]	]	-RRB-
cord-012045-1cqqj84n	143	9	[	[	-LRB-
cord-012045-1cqqj84n	143	10	92	92	CD
cord-012045-1cqqj84n	143	11	]	]	-RRB-
cord-012045-1cqqj84n	144	1	Inhibits	inhibit	VBZ
cord-012045-1cqqj84n	144	2	type	type	NN
cord-012045-1cqqj84n	145	1	I	-PRON-	PRP
cord-012045-1cqqj84n	145	2	IFN	IFN	NNP
cord-012045-1cqqj84n	145	3	signaling	signal	VBG
cord-012045-1cqqj84n	145	4	and	and	CC
cord-012045-1cqqj84n	145	5	antiviral	antiviral	JJ
cord-012045-1cqqj84n	145	6	response	response	NN
cord-012045-1cqqj84n	145	7	[	[	-LRB-
cord-012045-1cqqj84n	145	8	92	92	CD
cord-012045-1cqqj84n	145	9	]	]	-RRB-
cord-012045-1cqqj84n	146	1	POH1	POH1	NNP
cord-012045-1cqqj84n	146	2	pro	pro	JJ
cord-012045-1cqqj84n	146	3	-	-	JJ
cord-012045-1cqqj84n	146	4	IL-1β	il-1β	JJ
cord-012045-1cqqj84n	147	1	[	[	-LRB-
cord-012045-1cqqj84n	147	2	93	93	CD
cord-012045-1cqqj84n	147	3	]	]	-RRB-
cord-012045-1cqqj84n	147	4	Negatively	negatively	RB
cord-012045-1cqqj84n	147	5	regulates	regulate	VBZ
cord-012045-1cqqj84n	147	6	the	the	DT
cord-012045-1cqqj84n	147	7	immune	immune	JJ
cord-012045-1cqqj84n	147	8	response	response	NN
cord-012045-1cqqj84n	147	9	[	[	-LRB-
cord-012045-1cqqj84n	147	10	93	93	CD
cord-012045-1cqqj84n	147	11	]	]	-RRB-
cord-012045-1cqqj84n	147	12	BRCC3	BRCC3	NNS
cord-012045-1cqqj84n	148	1	NLRP3	NLRP3	NNP
cord-012045-1cqqj84n	149	1	[	[	-LRB-
cord-012045-1cqqj84n	149	2	94	94	CD
cord-012045-1cqqj84n	149	3	]	]	-RRB-
cord-012045-1cqqj84n	149	4	Promotes	promote	VBZ
cord-012045-1cqqj84n	149	5	the	the	DT
cord-012045-1cqqj84n	149	6	inflammasome	inflammasome	NN
cord-012045-1cqqj84n	149	7	activation	activation	NN
cord-012045-1cqqj84n	149	8	[	[	-LRB-
cord-012045-1cqqj84n	149	9	94	94	CD
cord-012045-1cqqj84n	149	10	]	]	-RRB-
cord-012045-1cqqj84n	149	11	STAMBP	STAMBP	NNP
cord-012045-1cqqj84n	150	1	NALP7	NALP7	NNP
cord-012045-1cqqj84n	151	1	[	[	-LRB-
cord-012045-1cqqj84n	151	2	95	95	CD
cord-012045-1cqqj84n	151	3	]	]	-RRB-
cord-012045-1cqqj84n	151	4	Reduces	reduce	VBZ
cord-012045-1cqqj84n	151	5	pro	pro	JJ
cord-012045-1cqqj84n	151	6	-	-	JJ
cord-012045-1cqqj84n	151	7	inflammatory	inflammatory	JJ
cord-012045-1cqqj84n	151	8	stress	stress	NN
cord-012045-1cqqj84n	151	9	[	[	-LRB-
cord-012045-1cqqj84n	151	10	95	95	CD
cord-012045-1cqqj84n	151	11	]	]	-RRB-
cord-012045-1cqqj84n	152	1	Alveolar	alveolar	JJ
cord-012045-1cqqj84n	152	2	residential	residential	JJ
cord-012045-1cqqj84n	152	3	macrophages	macrophage	NNS
cord-012045-1cqqj84n	152	4	are	be	VBP
cord-012045-1cqqj84n	152	5	central	central	JJ
cord-012045-1cqqj84n	152	6	to	to	IN
cord-012045-1cqqj84n	152	7	the	the	DT
cord-012045-1cqqj84n	152	8	development	development	NN
cord-012045-1cqqj84n	152	9	of	of	IN
cord-012045-1cqqj84n	152	10	the	the	DT
cord-012045-1cqqj84n	152	11	inflammatory	inflammatory	JJ
cord-012045-1cqqj84n	152	12	response	response	NN
cord-012045-1cqqj84n	152	13	by	by	IN
cord-012045-1cqqj84n	152	14	recruiting	recruit	VBG
cord-012045-1cqqj84n	152	15	neutrophils	neutrophil	NNS
cord-012045-1cqqj84n	152	16	and	and	CC
cord-012045-1cqqj84n	152	17	circulating	circulate	VBG
cord-012045-1cqqj84n	152	18	macrophages	macrophage	NNS
cord-012045-1cqqj84n	152	19	to	to	IN
cord-012045-1cqqj84n	152	20	the	the	DT
cord-012045-1cqqj84n	152	21	site	site	NN
cord-012045-1cqqj84n	152	22	of	of	IN
cord-012045-1cqqj84n	152	23	injury	injury	NN
cord-012045-1cqqj84n	152	24	,	,	,
cord-012045-1cqqj84n	152	25	their	-PRON-	PRP$
cord-012045-1cqqj84n	152	26	functions	function	NNS
cord-012045-1cqqj84n	152	27	are	be	VBP
cord-012045-1cqqj84n	152	28	modulated	modulate	VBN
cord-012045-1cqqj84n	152	29	by	by	IN
cord-012045-1cqqj84n	152	30	deubiquitinating	deubiquitinate	VBG
cord-012045-1cqqj84n	152	31	enzymes	enzyme	NNS
cord-012045-1cqqj84n	152	32	[	[	-LRB-
cord-012045-1cqqj84n	152	33	96	96	CD
cord-012045-1cqqj84n	152	34	,	,	,
cord-012045-1cqqj84n	152	35	97	97	CD
cord-012045-1cqqj84n	152	36	]	]	-RRB-
cord-012045-1cqqj84n	152	37	.	.	.
cord-012045-1cqqj84n	153	1	These	these	DT
cord-012045-1cqqj84n	153	2	cells	cell	NNS
cord-012045-1cqqj84n	153	3	secrete	secrete	VBP
cord-012045-1cqqj84n	153	4	cytokines	cytokine	NNS
cord-012045-1cqqj84n	153	5	,	,	,
cord-012045-1cqqj84n	153	6	chemokines	chemokine	NNS
cord-012045-1cqqj84n	153	7	,	,	,
cord-012045-1cqqj84n	153	8	reactive	reactive	JJ
cord-012045-1cqqj84n	153	9	oxygen	oxygen	NN
cord-012045-1cqqj84n	153	10	species	specie	NNS
cord-012045-1cqqj84n	153	11	,	,	,
cord-012045-1cqqj84n	153	12	proteases	protease	NNS
cord-012045-1cqqj84n	153	13	,	,	,
cord-012045-1cqqj84n	153	14	and	and	CC
cord-012045-1cqqj84n	153	15	other	other	JJ
cord-012045-1cqqj84n	153	16	mediators	mediator	NNS
cord-012045-1cqqj84n	153	17	that	that	WDT
cord-012045-1cqqj84n	153	18	modulate	modulate	VBP
cord-012045-1cqqj84n	153	19	the	the	DT
cord-012045-1cqqj84n	153	20	inflammatory	inflammatory	JJ
cord-012045-1cqqj84n	153	21	responses	response	NNS
cord-012045-1cqqj84n	153	22	and	and	CC
cord-012045-1cqqj84n	153	23	injure	injure	VB
cord-012045-1cqqj84n	153	24	the	the	DT
cord-012045-1cqqj84n	153	25	alveolocapillary	alveolocapillary	JJ
cord-012045-1cqqj84n	153	26	barrier	barrier	NN
cord-012045-1cqqj84n	153	27	.	.	.
cord-012045-1cqqj84n	154	1	Gram	gram	NN
cord-012045-1cqqj84n	154	2	-	-	HYPH
cord-012045-1cqqj84n	154	3	negative	negative	JJ
cord-012045-1cqqj84n	154	4	bacteria	bacteria	NNS
cord-012045-1cqqj84n	154	5	-	-	HYPH
cord-012045-1cqqj84n	154	6	derived	derive	VBN
cord-012045-1cqqj84n	154	7	endotoxin	endotoxin	NN
cord-012045-1cqqj84n	154	8	lipopolysaccharide	lipopolysaccharide	NN
cord-012045-1cqqj84n	154	9	(	(	-LRB-
cord-012045-1cqqj84n	154	10	LPS	LPS	NNP
cord-012045-1cqqj84n	154	11	)	)	-RRB-
cord-012045-1cqqj84n	154	12	promotes	promote	VBZ
cord-012045-1cqqj84n	154	13	stability	stability	NN
cord-012045-1cqqj84n	154	14	of	of	IN
cord-012045-1cqqj84n	154	15	a	a	DT
cord-012045-1cqqj84n	154	16	histone	histone	NN
cord-012045-1cqqj84n	154	17	acetyltransferase	acetyltransferase	NNP
cord-012045-1cqqj84n	154	18	HBO1	HBO1	NNP
cord-012045-1cqqj84n	154	19	via	via	IN
cord-012045-1cqqj84n	154	20	the	the	DT
cord-012045-1cqqj84n	154	21	function	function	NN
cord-012045-1cqqj84n	154	22	of	of	IN
cord-012045-1cqqj84n	154	23	USP25	USP25	NNP
cord-012045-1cqqj84n	154	24	.	.	.
cord-012045-1cqqj84n	155	1	HBO1	HBO1	NNP
cord-012045-1cqqj84n	155	2	is	be	VBZ
cord-012045-1cqqj84n	155	3	believed	believe	VBN
cord-012045-1cqqj84n	155	4	to	to	TO
cord-012045-1cqqj84n	155	5	fire	fire	VB
cord-012045-1cqqj84n	155	6	DNA	dna	NN
cord-012045-1cqqj84n	155	7	replication	replication	NN
cord-012045-1cqqj84n	155	8	licensing	licensing	NN
cord-012045-1cqqj84n	155	9	at	at	IN
cord-012045-1cqqj84n	155	10	the	the	DT
cord-012045-1cqqj84n	155	11	S	s	NN
cord-012045-1cqqj84n	155	12	-	-	HYPH
cord-012045-1cqqj84n	155	13	phase	phase	NN
cord-012045-1cqqj84n	155	14	of	of	IN
cord-012045-1cqqj84n	155	15	the	the	DT
cord-012045-1cqqj84n	155	16	cell	cell	NN
cord-012045-1cqqj84n	155	17	cycle	cycle	NN
cord-012045-1cqqj84n	155	18	,	,	,
cord-012045-1cqqj84n	155	19	however	however	RB
cord-012045-1cqqj84n	155	20	,	,	,
cord-012045-1cqqj84n	155	21	it	-PRON-	PRP
cord-012045-1cqqj84n	155	22	also	also	RB
cord-012045-1cqqj84n	155	23	regulates	regulate	VBZ
cord-012045-1cqqj84n	155	24	inflammatory	inflammatory	JJ
cord-012045-1cqqj84n	155	25	gene	gene	NN
cord-012045-1cqqj84n	155	26	transcription	transcription	NN
cord-012045-1cqqj84n	155	27	in	in	IN
cord-012045-1cqqj84n	155	28	settings	setting	NNS
cord-012045-1cqqj84n	155	29	of	of	IN
cord-012045-1cqqj84n	155	30	pulmonary	pulmonary	JJ
cord-012045-1cqqj84n	155	31	infection	infection	NN
cord-012045-1cqqj84n	155	32	.	.	.
cord-012045-1cqqj84n	156	1	USP25-stabilized	usp25-stabilize	VBN
cord-012045-1cqqj84n	156	2	HBO1	HBO1	NNP
cord-012045-1cqqj84n	156	3	promotes	promote	VBZ
cord-012045-1cqqj84n	156	4	inflammatory	inflammatory	JJ
cord-012045-1cqqj84n	156	5	gene	gene	NN
cord-012045-1cqqj84n	156	6	transcription	transcription	NN
cord-012045-1cqqj84n	156	7	in	in	IN
cord-012045-1cqqj84n	156	8	monocyte	monocyte	NNP
cord-012045-1cqqj84n	156	9	THP-1	THP-1	NNP
cord-012045-1cqqj84n	156	10	cells	cell	NNS
cord-012045-1cqqj84n	156	11	[	[	-LRB-
cord-012045-1cqqj84n	156	12	67	67	CD
cord-012045-1cqqj84n	156	13	]	]	-RRB-
cord-012045-1cqqj84n	156	14	.	.	.
cord-012045-1cqqj84n	157	1	In	in	IN
cord-012045-1cqqj84n	157	2	addition	addition	NN
cord-012045-1cqqj84n	157	3	,	,	,
cord-012045-1cqqj84n	157	4	inhibition	inhibition	NN
cord-012045-1cqqj84n	157	5	of	of	IN
cord-012045-1cqqj84n	157	6	USP7	USP7	NNP
cord-012045-1cqqj84n	157	7	and	and	CC
cord-012045-1cqqj84n	157	8	USP47	USP47	NNP
cord-012045-1cqqj84n	157	9	blocks	block	VBZ
cord-012045-1cqqj84n	157	10	the	the	DT
cord-012045-1cqqj84n	157	11	NLRP3	nlrp3	XX
cord-012045-1cqqj84n	157	12	inflammasome	inflammasome	NNP
cord-012045-1cqqj84n	157	13	by	by	IN
cord-012045-1cqqj84n	157	14	preventing	prevent	VBG
cord-012045-1cqqj84n	157	15	apeck	apeck	NN
cord-012045-1cqqj84n	157	16	-	-	HYPH
cord-012045-1cqqj84n	157	17	like	like	JJ
cord-012045-1cqqj84n	157	18	protein	protein	NN
cord-012045-1cqqj84n	157	19	containing	contain	VBG
cord-012045-1cqqj84n	157	20	a	a	DT
cord-012045-1cqqj84n	157	21	CARD	card	NN
cord-012045-1cqqj84n	157	22	(	(	-LRB-
cord-012045-1cqqj84n	157	23	ASC	ASC	NNP
cord-012045-1cqqj84n	157	24	)	)	-RRB-
cord-012045-1cqqj84n	157	25	oligomerization	oligomerization	NN
cord-012045-1cqqj84n	157	26	and	and	CC
cord-012045-1cqqj84n	157	27	speck	speck	NN
cord-012045-1cqqj84n	157	28	formation	formation	NN
cord-012045-1cqqj84n	157	29	in	in	IN
cord-012045-1cqqj84n	157	30	macrophages	macrophage	NNS
cord-012045-1cqqj84n	157	31	[	[	-LRB-
cord-012045-1cqqj84n	157	32	38	38	CD
cord-012045-1cqqj84n	157	33	]	]	-RRB-
cord-012045-1cqqj84n	157	34	.	.	.
cord-012045-1cqqj84n	158	1	USP17	USP17	NNP
cord-012045-1cqqj84n	158	2	mediates	mediate	VBZ
cord-012045-1cqqj84n	158	3	macrophage	macrophage	NN
cord-012045-1cqqj84n	158	4	-	-	HYPH
cord-012045-1cqqj84n	158	5	promoted	promote	VBN
cord-012045-1cqqj84n	158	6	inflammation	inflammation	NN
cord-012045-1cqqj84n	158	7	and	and	CC
cord-012045-1cqqj84n	158	8	stemness	stemness	JJ
cord-012045-1cqqj84n	158	9	in	in	IN
cord-012045-1cqqj84n	158	10	lung	lung	NN
cord-012045-1cqqj84n	158	11	cancer	cancer	NN
cord-012045-1cqqj84n	158	12	cells	cell	NNS
cord-012045-1cqqj84n	158	13	by	by	IN
cord-012045-1cqqj84n	158	14	regulating	regulate	VBG
cord-012045-1cqqj84n	158	15	TRAF2	TRAF2	NNP
cord-012045-1cqqj84n	158	16	/	/	SYM
cord-012045-1cqqj84n	158	17	TRAF3	traf3	NN
cord-012045-1cqqj84n	158	18	complex	complex	JJ
cord-012045-1cqqj84n	158	19	formation	formation	NN
cord-012045-1cqqj84n	158	20	[	[	-LRB-
cord-012045-1cqqj84n	158	21	59	59	CD
cord-012045-1cqqj84n	158	22	]	]	-RRB-
cord-012045-1cqqj84n	158	23	.	.	.
cord-012045-1cqqj84n	159	1	The	the	DT
cord-012045-1cqqj84n	159	2	activity	activity	NN
cord-012045-1cqqj84n	159	3	of	of	IN
cord-012045-1cqqj84n	159	4	deubiquitination	deubiquitination	NN
cord-012045-1cqqj84n	159	5	regulates	regulate	VBZ
cord-012045-1cqqj84n	159	6	inflammasome	inflammasome	NNP
cord-012045-1cqqj84n	159	7	assembly	assembly	NN
cord-012045-1cqqj84n	159	8	and	and	CC
cord-012045-1cqqj84n	159	9	function	function	NN
cord-012045-1cqqj84n	159	10	.	.	.
cord-012045-1cqqj84n	160	1	Deubiquitination	deubiquitination	NN
cord-012045-1cqqj84n	160	2	of	of	IN
cord-012045-1cqqj84n	160	3	NLRP3	nlrp3	NN
cord-012045-1cqqj84n	160	4	has	have	VBZ
cord-012045-1cqqj84n	160	5	been	be	VBN
cord-012045-1cqqj84n	160	6	suggested	suggest	VBN
cord-012045-1cqqj84n	160	7	to	to	TO
cord-012045-1cqqj84n	160	8	contribute	contribute	VB
cord-012045-1cqqj84n	160	9	to	to	IN
cord-012045-1cqqj84n	160	10	inflammasome	inflammasome	NNP
cord-012045-1cqqj84n	160	11	activation	activation	NN
cord-012045-1cqqj84n	160	12	.	.	.
cord-012045-1cqqj84n	161	1	Upon	upon	IN
cord-012045-1cqqj84n	161	2	treatment	treatment	NN
cord-012045-1cqqj84n	161	3	with	with	IN
cord-012045-1cqqj84n	161	4	NLRP3	nlrp3	NN
cord-012045-1cqqj84n	161	5	ligands	ligand	NNS
cord-012045-1cqqj84n	161	6	after	after	IN
cord-012045-1cqqj84n	161	7	the	the	DT
cord-012045-1cqqj84n	161	8	priming	priming	NN
cord-012045-1cqqj84n	161	9	step	step	NN
cord-012045-1cqqj84n	161	10	,	,	,
cord-012045-1cqqj84n	161	11	ABRO1	abro1	RB
cord-012045-1cqqj84n	161	12	,	,	,
cord-012045-1cqqj84n	161	13	a	a	DT
cord-012045-1cqqj84n	161	14	subunit	subunit	NN
cord-012045-1cqqj84n	161	15	of	of	IN
cord-012045-1cqqj84n	161	16	the	the	DT
cord-012045-1cqqj84n	161	17	BRISC	BRISC	NNP
cord-012045-1cqqj84n	161	18	deubiquitinating	deubiquitinating	NN
cord-012045-1cqqj84n	161	19	complex	complex	NN
cord-012045-1cqqj84n	161	20	,	,	,
cord-012045-1cqqj84n	161	21	is	be	VBZ
cord-012045-1cqqj84n	161	22	required	require	VBN
cord-012045-1cqqj84n	161	23	for	for	IN
cord-012045-1cqqj84n	161	24	optimal	optimal	JJ
cord-012045-1cqqj84n	161	25	NLRP3-ASC	nlrp3-asc	NN
cord-012045-1cqqj84n	161	26	complex	complex	JJ
cord-012045-1cqqj84n	161	27	formation	formation	NN
cord-012045-1cqqj84n	161	28	,	,	,
cord-012045-1cqqj84n	161	29	ASC	ASC	NNP
cord-012045-1cqqj84n	161	30	oligomerization	oligomerization	NN
cord-012045-1cqqj84n	161	31	,	,	,
cord-012045-1cqqj84n	161	32	caspase-1	caspase-1	NNP
cord-012045-1cqqj84n	161	33	activation	activation	NN
cord-012045-1cqqj84n	161	34	,	,	,
cord-012045-1cqqj84n	161	35	and	and	CC
cord-012045-1cqqj84n	161	36	IL-1β	il-1β	NN
cord-012045-1cqqj84n	161	37	and	and	CC
cord-012045-1cqqj84n	161	38	IL-18	IL-18	NNP
cord-012045-1cqqj84n	161	39	production	production	NN
cord-012045-1cqqj84n	161	40	.	.	.
cord-012045-1cqqj84n	162	1	This	this	DT
cord-012045-1cqqj84n	162	2	evidence	evidence	NN
cord-012045-1cqqj84n	162	3	indicates	indicate	VBZ
cord-012045-1cqqj84n	162	4	that	that	IN
cord-012045-1cqqj84n	162	5	efficient	efficient	JJ
cord-012045-1cqqj84n	162	6	NLRP3	nlrp3	NN
cord-012045-1cqqj84n	162	7	activation	activation	NN
cord-012045-1cqqj84n	162	8	requires	require	VBZ
cord-012045-1cqqj84n	162	9	ABRO1	ABRO1	NNP
cord-012045-1cqqj84n	162	10	[	[	-LRB-
cord-012045-1cqqj84n	162	11	98	98	CD
cord-012045-1cqqj84n	162	12	]	]	-RRB-
cord-012045-1cqqj84n	162	13	.	.	.
cord-012045-1cqqj84n	163	1	Protein	protein	NN
cord-012045-1cqqj84n	163	2	kinase	kinase	NN
cord-012045-1cqqj84n	163	3	JNK1	jnk1	CC
cord-012045-1cqqj84n	163	4	catalyzes	catalyze	VBZ
cord-012045-1cqqj84n	163	5	NLRP3	nlrp3	NN
cord-012045-1cqqj84n	163	6	phosphorylation	phosphorylation	NN
cord-012045-1cqqj84n	163	7	at	at	IN
cord-012045-1cqqj84n	163	8	S194	s194	CD
cord-012045-1cqqj84n	164	1	within	within	IN
cord-012045-1cqqj84n	164	2	NLRP3	NLRP3	NNP
cord-012045-1cqqj84n	164	3	,	,	,
cord-012045-1cqqj84n	164	4	which	which	WDT
cord-012045-1cqqj84n	164	5	is	be	VBZ
cord-012045-1cqqj84n	164	6	critical	critical	JJ
cord-012045-1cqqj84n	164	7	for	for	IN
cord-012045-1cqqj84n	164	8	NLRP3	NLRP3	NNP
cord-012045-1cqqj84n	164	9	deubiquitination	deubiquitination	NN
cord-012045-1cqqj84n	164	10	and	and	CC
cord-012045-1cqqj84n	164	11	facilitates	facilitate	VBZ
cord-012045-1cqqj84n	164	12	its	-PRON-	PRP$
cord-012045-1cqqj84n	164	13	self	self	NN
cord-012045-1cqqj84n	164	14	-	-	HYPH
cord-012045-1cqqj84n	164	15	association	association	NN
cord-012045-1cqqj84n	164	16	and	and	CC
cord-012045-1cqqj84n	164	17	the	the	DT
cord-012045-1cqqj84n	164	18	subsequent	subsequent	JJ
cord-012045-1cqqj84n	164	19	inflammasome	inflammasome	NN
cord-012045-1cqqj84n	164	20	assembly	assembly	NN
cord-012045-1cqqj84n	164	21	[	[	-LRB-
cord-012045-1cqqj84n	164	22	99	99	CD
cord-012045-1cqqj84n	164	23	]	]	-RRB-
cord-012045-1cqqj84n	164	24	.	.	.
cord-012045-1cqqj84n	165	1	Another	another	DT
cord-012045-1cqqj84n	165	2	inflammasome	inflammasome	NN
cord-012045-1cqqj84n	165	3	component	component	NN
cord-012045-1cqqj84n	165	4	NALP7	nalp7	NN
cord-012045-1cqqj84n	165	5	is	be	VBZ
cord-012045-1cqqj84n	165	6	regulated	regulate	VBN
cord-012045-1cqqj84n	165	7	by	by	IN
cord-012045-1cqqj84n	165	8	the	the	DT
cord-012045-1cqqj84n	165	9	deubiquitinating	deubiquitinating	NN
cord-012045-1cqqj84n	165	10	enzyme	enzyme	NN
cord-012045-1cqqj84n	165	11	STAM	stam	NN
cord-012045-1cqqj84n	165	12	-	-	HYPH
cord-012045-1cqqj84n	165	13	binding	bind	VBG
cord-012045-1cqqj84n	165	14	protein	protein	NN
cord-012045-1cqqj84n	165	15	(	(	-LRB-
cord-012045-1cqqj84n	165	16	STAMBP	STAMBP	NNP
cord-012045-1cqqj84n	165	17	)	)	-RRB-
cord-012045-1cqqj84n	165	18	,	,	,
cord-012045-1cqqj84n	165	19	targeting	target	VBG
cord-012045-1cqqj84n	165	20	the	the	DT
cord-012045-1cqqj84n	165	21	STAMBP	STAMBP	NNP
cord-012045-1cqqj84n	165	22	with	with	IN
cord-012045-1cqqj84n	165	23	a	a	DT
cord-012045-1cqqj84n	165	24	small	small	JJ
cord-012045-1cqqj84n	165	25	molecule	molecule	NN
cord-012045-1cqqj84n	165	26	that	that	WDT
cord-012045-1cqqj84n	165	27	inhibits	inhibit	VBZ
cord-012045-1cqqj84n	165	28	NALP7	nalp7	JJ
cord-012045-1cqqj84n	165	29	inflammasome	inflammasome	NN
cord-012045-1cqqj84n	165	30	activity	activity	NN
cord-012045-1cqqj84n	165	31	[	[	-LRB-
cord-012045-1cqqj84n	165	32	95	95	CD
cord-012045-1cqqj84n	165	33	]	]	-RRB-
cord-012045-1cqqj84n	165	34	.	.	.
cord-012045-1cqqj84n	166	1	The	the	DT
cord-012045-1cqqj84n	166	2	activities	activity	NNS
cord-012045-1cqqj84n	166	3	of	of	IN
cord-012045-1cqqj84n	166	4	deubiquitinating	deubiquitinating	NN
cord-012045-1cqqj84n	166	5	enzymes	enzyme	NNS
cord-012045-1cqqj84n	166	6	are	be	VBP
cord-012045-1cqqj84n	166	7	involved	involve	VBN
cord-012045-1cqqj84n	166	8	in	in	IN
cord-012045-1cqqj84n	166	9	many	many	JJ
cord-012045-1cqqj84n	166	10	aspects	aspect	NNS
cord-012045-1cqqj84n	166	11	of	of	IN
cord-012045-1cqqj84n	166	12	the	the	DT
cord-012045-1cqqj84n	166	13	pathogenesis	pathogenesis	NN
cord-012045-1cqqj84n	166	14	in	in	IN
cord-012045-1cqqj84n	166	15	ALI	ALI	NNP
cord-012045-1cqqj84n	166	16	/	/	SYM
cord-012045-1cqqj84n	166	17	ARD	ARD	NNP
cord-012045-1cqqj84n	166	18	.	.	.
cord-012045-1cqqj84n	167	1	Lung	lung	NN
cord-012045-1cqqj84n	167	2	epithelial	epithelial	JJ
cord-012045-1cqqj84n	167	3	cell	cell	NN
cord-012045-1cqqj84n	167	4	death	death	NN
cord-012045-1cqqj84n	167	5	is	be	VBZ
cord-012045-1cqqj84n	167	6	a	a	DT
cord-012045-1cqqj84n	167	7	hallmark	hallmark	NN
cord-012045-1cqqj84n	167	8	in	in	IN
cord-012045-1cqqj84n	167	9	ALI	ALI	NNP
cord-012045-1cqqj84n	167	10	/	/	SYM
cord-012045-1cqqj84n	167	11	ARDS	ARDS	NNP
cord-012045-1cqqj84n	167	12	.	.	.
cord-012045-1cqqj84n	168	1	Massive	massive	JJ
cord-012045-1cqqj84n	168	2	lung	lung	NN
cord-012045-1cqqj84n	168	3	epithelial	epithelial	JJ
cord-012045-1cqqj84n	168	4	cell	cell	NN
cord-012045-1cqqj84n	168	5	death	death	NN
cord-012045-1cqqj84n	168	6	has	have	VBZ
cord-012045-1cqqj84n	168	7	been	be	VBN
cord-012045-1cqqj84n	168	8	reported	report	VBN
cord-012045-1cqqj84n	168	9	in	in	IN
cord-012045-1cqqj84n	168	10	ARDS	ARDS	NNP
cord-012045-1cqqj84n	168	11	patients	patient	NNS
cord-012045-1cqqj84n	168	12	.	.	.
cord-012045-1cqqj84n	169	1	Lung	lung	NN
cord-012045-1cqqj84n	169	2	epithelial	epithelial	JJ
cord-012045-1cqqj84n	169	3	cell	cell	NN
cord-012045-1cqqj84n	169	4	death	death	NN
cord-012045-1cqqj84n	169	5	is	be	VBZ
cord-012045-1cqqj84n	169	6	regulated	regulate	VBN
cord-012045-1cqqj84n	169	7	by	by	IN
cord-012045-1cqqj84n	169	8	deubiquitinating	deubiquitinate	VBG
cord-012045-1cqqj84n	169	9	enzymes	enzyme	NNS
cord-012045-1cqqj84n	169	10	.	.	.
cord-012045-1cqqj84n	170	1	Loss	loss	NN
cord-012045-1cqqj84n	170	2	of	of	IN
cord-012045-1cqqj84n	170	3	DUB	DUB	NNP
cord-012045-1cqqj84n	170	4	CYLD	CYLD	NNP
cord-012045-1cqqj84n	170	5	can	can	MD
cord-012045-1cqqj84n	170	6	activate	activate	VB
cord-012045-1cqqj84n	170	7	NF	NF	NNP
cord-012045-1cqqj84n	170	8	-	-	HYPH
cord-012045-1cqqj84n	170	9	κB	κB	NNP
cord-012045-1cqqj84n	170	10	to	to	TO
cord-012045-1cqqj84n	170	11	inhibit	inhibit	VB
cord-012045-1cqqj84n	170	12	apoptosis	apoptosis	NN
cord-012045-1cqqj84n	170	13	in	in	IN
cord-012045-1cqqj84n	170	14	lung	lung	NN
cord-012045-1cqqj84n	170	15	epithelial	epithelial	NN
cord-012045-1cqqj84n	170	16	cells	cell	NNS
cord-012045-1cqqj84n	170	17	[	[	-LRB-
cord-012045-1cqqj84n	170	18	100	100	CD
cord-012045-1cqqj84n	170	19	]	]	-RRB-
cord-012045-1cqqj84n	170	20	.	.	.
cord-012045-1cqqj84n	171	1	In	in	IN
cord-012045-1cqqj84n	171	2	lung	lung	NN
cord-012045-1cqqj84n	171	3	infection	infection	NN
cord-012045-1cqqj84n	171	4	,	,	,
cord-012045-1cqqj84n	171	5	USP13	USP13	NNP
cord-012045-1cqqj84n	171	6	are	be	VBP
cord-012045-1cqqj84n	171	7	aberrantly	aberrantly	RB
cord-012045-1cqqj84n	171	8	expressed	express	VBN
cord-012045-1cqqj84n	171	9	,	,	,
cord-012045-1cqqj84n	171	10	inhibition	inhibition	NN
cord-012045-1cqqj84n	171	11	of	of	IN
cord-012045-1cqqj84n	171	12	USP13	USP13	NNP
cord-012045-1cqqj84n	171	13	reduces	reduce	VBZ
cord-012045-1cqqj84n	171	14	the	the	DT
cord-012045-1cqqj84n	171	15	abundance	abundance	NN
cord-012045-1cqqj84n	171	16	of	of	IN
cord-012045-1cqqj84n	171	17	anti	anti	JJ
cord-012045-1cqqj84n	171	18	-	-	JJ
cord-012045-1cqqj84n	171	19	apoptotic	apoptotic	JJ
cord-012045-1cqqj84n	171	20	protein	protein	NN
cord-012045-1cqqj84n	171	21	MCL1	MCL1	NNP
cord-012045-1cqqj84n	171	22	in	in	IN
cord-012045-1cqqj84n	171	23	the	the	DT
cord-012045-1cqqj84n	171	24	lung	lung	NN
cord-012045-1cqqj84n	171	25	[	[	-LRB-
cord-012045-1cqqj84n	171	26	42	42	CD
cord-012045-1cqqj84n	171	27	]	]	-RRB-
cord-012045-1cqqj84n	171	28	.	.	.
cord-012045-1cqqj84n	172	1	On	on	IN
cord-012045-1cqqj84n	172	2	the	the	DT
cord-012045-1cqqj84n	172	3	other	other	JJ
cord-012045-1cqqj84n	172	4	hand	hand	NN
cord-012045-1cqqj84n	172	5	,	,	,
cord-012045-1cqqj84n	172	6	recent	recent	JJ
cord-012045-1cqqj84n	172	7	mechanistic	mechanistic	JJ
cord-012045-1cqqj84n	172	8	studies	study	NNS
cord-012045-1cqqj84n	172	9	have	have	VBP
cord-012045-1cqqj84n	172	10	reported	report	VBN
cord-012045-1cqqj84n	172	11	that	that	IN
cord-012045-1cqqj84n	172	12	lung	lung	NN
cord-012045-1cqqj84n	172	13	epithelial	epithelial	NN
cord-012045-1cqqj84n	172	14	cells	cell	NNS
cord-012045-1cqqj84n	172	15	may	may	MD
cord-012045-1cqqj84n	172	16	defend	defend	VB
cord-012045-1cqqj84n	172	17	from	from	IN
cord-012045-1cqqj84n	172	18	bacterial	bacterial	JJ
cord-012045-1cqqj84n	172	19	invasion	invasion	NN
cord-012045-1cqqj84n	172	20	through	through	IN
cord-012045-1cqqj84n	172	21	several	several	JJ
cord-012045-1cqqj84n	172	22	mechanisms	mechanism	NNS
cord-012045-1cqqj84n	172	23	.	.	.
cord-012045-1cqqj84n	173	1	USP25	USP25	NNP
cord-012045-1cqqj84n	173	2	may	may	MD
cord-012045-1cqqj84n	173	3	regulate	regulate	VB
cord-012045-1cqqj84n	173	4	the	the	DT
cord-012045-1cqqj84n	173	5	degradation	degradation	NN
cord-012045-1cqqj84n	173	6	of	of	IN
cord-012045-1cqqj84n	173	7	a	a	DT
cord-012045-1cqqj84n	173	8	deacetylation	deacetylation	NN
cord-012045-1cqqj84n	173	9	enzyme	enzyme	NN
cord-012045-1cqqj84n	173	10	HDAC11	HDAC11	NNP
cord-012045-1cqqj84n	173	11	to	to	TO
cord-012045-1cqqj84n	173	12	modulate	modulate	VB
cord-012045-1cqqj84n	173	13	cellular	cellular	JJ
cord-012045-1cqqj84n	173	14	Pseudomonas	Pseudomonas	NNP
cord-012045-1cqqj84n	173	15	aeruginosa	aeruginosa	NN
cord-012045-1cqqj84n	173	16	bacterial	bacterial	JJ
cord-012045-1cqqj84n	173	17	load	load	NN
cord-012045-1cqqj84n	173	18	,	,	,
cord-012045-1cqqj84n	173	19	probably	probably	RB
cord-012045-1cqqj84n	173	20	via	via	IN
cord-012045-1cqqj84n	173	21	interferon	interferon	NN
cord-012045-1cqqj84n	173	22	signaling	signal	VBG
cord-012045-1cqqj84n	173	23	in	in	IN
cord-012045-1cqqj84n	173	24	bronchial	bronchial	JJ
cord-012045-1cqqj84n	173	25	lung	lung	NN
cord-012045-1cqqj84n	173	26	epithelial	epithelial	NN
cord-012045-1cqqj84n	173	27	cells	cell	NNS
cord-012045-1cqqj84n	173	28	[	[	-LRB-
cord-012045-1cqqj84n	173	29	68	68	CD
cord-012045-1cqqj84n	173	30	]	]	-RRB-
cord-012045-1cqqj84n	173	31	.	.	.
cord-012045-1cqqj84n	174	1	OTUB1	OTUB1	NNP
cord-012045-1cqqj84n	174	2	interferes	interfere	VBZ
cord-012045-1cqqj84n	174	3	with	with	IN
cord-012045-1cqqj84n	174	4	bacterial	bacterial	JJ
cord-012045-1cqqj84n	174	5	uptake	uptake	NN
cord-012045-1cqqj84n	174	6	by	by	IN
cord-012045-1cqqj84n	174	7	modulating	modulate	VBG
cord-012045-1cqqj84n	174	8	the	the	DT
cord-012045-1cqqj84n	174	9	RhoA	RhoA	NNP
cord-012045-1cqqj84n	174	10	level	level	NN
cord-012045-1cqqj84n	174	11	[	[	-LRB-
cord-012045-1cqqj84n	174	12	78	78	CD
cord-012045-1cqqj84n	174	13	]	]	-RRB-
cord-012045-1cqqj84n	174	14	.	.	.
cord-012045-1cqqj84n	175	1	Furthermore	furthermore	RB
cord-012045-1cqqj84n	175	2	,	,	,
cord-012045-1cqqj84n	175	3	deubiquitination	deubiquitination	NN
cord-012045-1cqqj84n	175	4	has	have	VBZ
cord-012045-1cqqj84n	175	5	been	be	VBN
cord-012045-1cqqj84n	175	6	proposed	propose	VBN
cord-012045-1cqqj84n	175	7	to	to	TO
cord-012045-1cqqj84n	175	8	play	play	VB
cord-012045-1cqqj84n	175	9	an	an	DT
cord-012045-1cqqj84n	175	10	important	important	JJ
cord-012045-1cqqj84n	175	11	role	role	NN
cord-012045-1cqqj84n	175	12	in	in	IN
cord-012045-1cqqj84n	175	13	alveolar	alveolar	JJ
cord-012045-1cqqj84n	175	14	epithelial	epithelial	JJ
cord-012045-1cqqj84n	175	15	dysfunction	dysfunction	NN
cord-012045-1cqqj84n	175	16	during	during	IN
cord-012045-1cqqj84n	175	17	ALI	ALI	NNP
cord-012045-1cqqj84n	175	18	.	.	.
cord-012045-1cqqj84n	176	1	USP10	USP10	NNP
cord-012045-1cqqj84n	176	2	exerts	exert	VBZ
cord-012045-1cqqj84n	176	3	an	an	DT
cord-012045-1cqqj84n	176	4	effect	effect	NN
cord-012045-1cqqj84n	176	5	on	on	IN
cord-012045-1cqqj84n	176	6	mucociliary	mucociliary	JJ
cord-012045-1cqqj84n	176	7	clearance	clearance	NN
cord-012045-1cqqj84n	176	8	by	by	IN
cord-012045-1cqqj84n	176	9	regulating	regulate	VBG
cord-012045-1cqqj84n	176	10	the	the	DT
cord-012045-1cqqj84n	176	11	endocytic	endocytic	JJ
cord-012045-1cqqj84n	176	12	recycling	recycling	NN
cord-012045-1cqqj84n	176	13	of	of	IN
cord-012045-1cqqj84n	176	14	the	the	DT
cord-012045-1cqqj84n	176	15	cystic	cystic	JJ
cord-012045-1cqqj84n	176	16	fibrosis	fibrosis	NN
cord-012045-1cqqj84n	176	17	transmembrane	transmembrane	NNP
cord-012045-1cqqj84n	176	18	conductance	conductance	NN
cord-012045-1cqqj84n	176	19	regulator	regulator	NN
cord-012045-1cqqj84n	176	20	(	(	-LRB-
cord-012045-1cqqj84n	176	21	CFTR	CFTR	NNP
cord-012045-1cqqj84n	176	22	)	)	-RRB-
cord-012045-1cqqj84n	176	23	in	in	IN
cord-012045-1cqqj84n	176	24	airway	airway	JJ
cord-012045-1cqqj84n	176	25	epithelial	epithelial	JJ
cord-012045-1cqqj84n	176	26	cells	cell	NNS
cord-012045-1cqqj84n	176	27	[	[	-LRB-
cord-012045-1cqqj84n	176	28	37	37	CD
cord-012045-1cqqj84n	176	29	,	,	,
cord-012045-1cqqj84n	176	30	52	52	CD
cord-012045-1cqqj84n	176	31	]	]	-RRB-
cord-012045-1cqqj84n	176	32	.	.	.
cord-012045-1cqqj84n	177	1	In	in	IN
cord-012045-1cqqj84n	177	2	addition	addition	NN
cord-012045-1cqqj84n	177	3	,	,	,
cord-012045-1cqqj84n	177	4	accumulating	accumulate	VBG
cord-012045-1cqqj84n	177	5	data	datum	NNS
cord-012045-1cqqj84n	177	6	suggest	suggest	VBP
cord-012045-1cqqj84n	177	7	that	that	IN
cord-012045-1cqqj84n	177	8	deubiquitination	deubiquitination	NN
cord-012045-1cqqj84n	177	9	may	may	MD
cord-012045-1cqqj84n	177	10	regulate	regulate	VB
cord-012045-1cqqj84n	177	11	structural	structural	JJ
cord-012045-1cqqj84n	177	12	components	component	NNS
cord-012045-1cqqj84n	177	13	of	of	IN
cord-012045-1cqqj84n	177	14	the	the	DT
cord-012045-1cqqj84n	177	15	alveolar	alveolar	JJ
cord-012045-1cqqj84n	177	16	epithelial	epithelial	JJ
cord-012045-1cqqj84n	177	17	monolayer	monolayer	NN
cord-012045-1cqqj84n	177	18	.	.	.
cord-012045-1cqqj84n	178	1	Structural	structural	JJ
cord-012045-1cqqj84n	178	2	integrity	integrity	NN
cord-012045-1cqqj84n	178	3	of	of	IN
cord-012045-1cqqj84n	178	4	epithelial	epithelial	JJ
cord-012045-1cqqj84n	178	5	cells	cell	NNS
cord-012045-1cqqj84n	178	6	and	and	CC
cord-012045-1cqqj84n	178	7	intercellular	intercellular	JJ
cord-012045-1cqqj84n	178	8	junctions	junction	NNS
cord-012045-1cqqj84n	178	9	plays	play	VBZ
cord-012045-1cqqj84n	178	10	an	an	DT
cord-012045-1cqqj84n	178	11	important	important	JJ
cord-012045-1cqqj84n	178	12	role	role	NN
cord-012045-1cqqj84n	178	13	in	in	IN
cord-012045-1cqqj84n	178	14	the	the	DT
cord-012045-1cqqj84n	178	15	maintenance	maintenance	NN
cord-012045-1cqqj84n	178	16	of	of	IN
cord-012045-1cqqj84n	178	17	alveolar	alveolar	JJ
cord-012045-1cqqj84n	178	18	epithelial	epithelial	JJ
cord-012045-1cqqj84n	178	19	barrier	barrier	NN
cord-012045-1cqqj84n	178	20	integrity	integrity	NN
cord-012045-1cqqj84n	178	21	.	.	.
cord-012045-1cqqj84n	179	1	A	a	DT
cord-012045-1cqqj84n	179	2	study	study	NN
cord-012045-1cqqj84n	179	3	suggests	suggest	VBZ
cord-012045-1cqqj84n	179	4	that	that	IN
cord-012045-1cqqj84n	179	5	phosphorylated	phosphorylated	JJ
cord-012045-1cqqj84n	179	6	E2F1	E2F1	NNP
cord-012045-1cqqj84n	179	7	is	be	VBZ
cord-012045-1cqqj84n	179	8	stabilized	stabilize	VBN
cord-012045-1cqqj84n	179	9	by	by	IN
cord-012045-1cqqj84n	179	10	nuclear	nuclear	JJ
cord-012045-1cqqj84n	179	11	USP11	usp11	NN
cord-012045-1cqqj84n	179	12	to	to	TO
cord-012045-1cqqj84n	179	13	drive	drive	VB
cord-012045-1cqqj84n	179	14	Peg10	Peg10	NNP
cord-012045-1cqqj84n	179	15	gene	gene	NN
cord-012045-1cqqj84n	179	16	expression	expression	NN
cord-012045-1cqqj84n	179	17	and	and	CC
cord-012045-1cqqj84n	179	18	activate	activate	VB
cord-012045-1cqqj84n	179	19	proliferation	proliferation	NN
cord-012045-1cqqj84n	179	20	of	of	IN
cord-012045-1cqqj84n	179	21	lung	lung	NN
cord-012045-1cqqj84n	179	22	epithelial	epithelial	NN
cord-012045-1cqqj84n	179	23	cells	cell	NNS
cord-012045-1cqqj84n	179	24	[	[	-LRB-
cord-012045-1cqqj84n	179	25	54	54	CD
cord-012045-1cqqj84n	179	26	]	]	-RRB-
cord-012045-1cqqj84n	179	27	.	.	.
cord-012045-1cqqj84n	180	1	Finally	finally	RB
cord-012045-1cqqj84n	180	2	,	,	,
cord-012045-1cqqj84n	180	3	airway	airway	JJ
cord-012045-1cqqj84n	180	4	barrier	barrier	NN
cord-012045-1cqqj84n	180	5	integrity	integrity	NN
cord-012045-1cqqj84n	180	6	is	be	VBZ
cord-012045-1cqqj84n	180	7	primarily	primarily	RB
cord-012045-1cqqj84n	180	8	maintained	maintain	VBN
cord-012045-1cqqj84n	180	9	by	by	IN
cord-012045-1cqqj84n	180	10	intercellular	intercellular	JJ
cord-012045-1cqqj84n	180	11	junctions	junction	NNS
cord-012045-1cqqj84n	180	12	,	,	,
cord-012045-1cqqj84n	180	13	which	which	WDT
cord-012045-1cqqj84n	180	14	in	in	IN
cord-012045-1cqqj84n	180	15	turn	turn	NN
cord-012045-1cqqj84n	180	16	control	control	VBP
cord-012045-1cqqj84n	180	17	the	the	DT
cord-012045-1cqqj84n	180	18	paracellular	paracellular	JJ
cord-012045-1cqqj84n	180	19	transport	transport	NN
cord-012045-1cqqj84n	180	20	of	of	IN
cord-012045-1cqqj84n	180	21	proteins	protein	NNS
cord-012045-1cqqj84n	180	22	,	,	,
cord-012045-1cqqj84n	180	23	fluids	fluid	NNS
cord-012045-1cqqj84n	180	24	,	,	,
cord-012045-1cqqj84n	180	25	and	and	CC
cord-012045-1cqqj84n	180	26	small	small	JJ
cord-012045-1cqqj84n	180	27	molecules	molecule	NNS
cord-012045-1cqqj84n	180	28	.	.	.
cord-012045-1cqqj84n	181	1	Cell	cell	NN
cord-012045-1cqqj84n	181	2	junction	junction	NN
cord-012045-1cqqj84n	181	3	and	and	CC
cord-012045-1cqqj84n	181	4	junctional	junctional	JJ
cord-012045-1cqqj84n	181	5	protein	protein	NN
cord-012045-1cqqj84n	181	6	recycling	recycling	NN
cord-012045-1cqqj84n	181	7	and	and	CC
cord-012045-1cqqj84n	181	8	remodeling	remodeling	NN
cord-012045-1cqqj84n	181	9	is	be	VBZ
cord-012045-1cqqj84n	181	10	pivotal	pivotal	JJ
cord-012045-1cqqj84n	181	11	in	in	IN
cord-012045-1cqqj84n	181	12	barrier	barrier	NN
cord-012045-1cqqj84n	181	13	integrity	integrity	NN
cord-012045-1cqqj84n	181	14	.	.	.
cord-012045-1cqqj84n	182	1	Deubiquitination	Deubiquitination	NNP
cord-012045-1cqqj84n	182	2	and	and	CC
cord-012045-1cqqj84n	182	3	DUBs	dub	NNS
cord-012045-1cqqj84n	182	4	have	have	VBP
cord-012045-1cqqj84n	182	5	been	be	VBN
cord-012045-1cqqj84n	182	6	shown	show	VBN
cord-012045-1cqqj84n	182	7	to	to	TO
cord-012045-1cqqj84n	182	8	regulate	regulate	VB
cord-012045-1cqqj84n	182	9	adherence	adherence	NN
cord-012045-1cqqj84n	182	10	of	of	IN
cord-012045-1cqqj84n	182	11	junctional	junctional	JJ
cord-012045-1cqqj84n	182	12	proteins	protein	NNS
cord-012045-1cqqj84n	182	13	[	[	-LRB-
cord-012045-1cqqj84n	182	14	101	101	CD
cord-012045-1cqqj84n	182	15	]	]	-RRB-
cord-012045-1cqqj84n	182	16	.	.	.
cord-012045-1cqqj84n	183	1	For	for	IN
cord-012045-1cqqj84n	183	2	example	example	NN
cord-012045-1cqqj84n	183	3	,	,	,
cord-012045-1cqqj84n	183	4	USP48	USP48	NNP
cord-012045-1cqqj84n	183	5	regulates	regulate	VBZ
cord-012045-1cqqj84n	183	6	E	e	NN
cord-012045-1cqqj84n	183	7	-	-	NN
cord-012045-1cqqj84n	183	8	cadherin	cadherin	JJ
cord-012045-1cqqj84n	183	9	mRNA	mrna	NN
cord-012045-1cqqj84n	183	10	levels	level	NNS
cord-012045-1cqqj84n	183	11	through	through	IN
cord-012045-1cqqj84n	183	12	stabilizing	stabilize	VBG
cord-012045-1cqqj84n	183	13	the	the	DT
cord-012045-1cqqj84n	183	14	TRAF2-JNK	TRAF2-JNK	NNP
cord-012045-1cqqj84n	183	15	pathway	pathway	NN
cord-012045-1cqqj84n	183	16	in	in	IN
cord-012045-1cqqj84n	183	17	lung	lung	NN
cord-012045-1cqqj84n	183	18	epithelial	epithelial	NN
cord-012045-1cqqj84n	183	19	cells	cell	NNS
cord-012045-1cqqj84n	183	20	[	[	-LRB-
cord-012045-1cqqj84n	183	21	69	69	CD
cord-012045-1cqqj84n	183	22	]	]	-RRB-
cord-012045-1cqqj84n	183	23	.	.	.
cord-012045-1cqqj84n	184	1	This	this	DT
cord-012045-1cqqj84n	184	2	study	study	NN
cord-012045-1cqqj84n	184	3	exhibits	exhibit	VBZ
cord-012045-1cqqj84n	184	4	an	an	DT
cord-012045-1cqqj84n	184	5	indirect	indirect	JJ
cord-012045-1cqqj84n	184	6	effect	effect	NN
cord-012045-1cqqj84n	184	7	of	of	IN
cord-012045-1cqqj84n	184	8	DUBs	dub	NNS
cord-012045-1cqqj84n	184	9	on	on	IN
cord-012045-1cqqj84n	184	10	regulation	regulation	NN
cord-012045-1cqqj84n	184	11	of	of	IN
cord-012045-1cqqj84n	184	12	E	e	NN
cord-012045-1cqqj84n	184	13	-	-	NN
cord-012045-1cqqj84n	184	14	cadherin	cadherin	JJ
cord-012045-1cqqj84n	184	15	levels	level	NNS
cord-012045-1cqqj84n	184	16	and	and	CC
cord-012045-1cqqj84n	184	17	lung	lung	NN
cord-012045-1cqqj84n	184	18	epithelial	epithelial	JJ
cord-012045-1cqqj84n	184	19	barrier	barrier	NN
cord-012045-1cqqj84n	184	20	integrity	integrity	NN
cord-012045-1cqqj84n	184	21	.	.	.
cord-012045-1cqqj84n	185	1	Until	until	IN
cord-012045-1cqqj84n	185	2	now	now	RB
cord-012045-1cqqj84n	185	3	,	,	,
cord-012045-1cqqj84n	185	4	the	the	DT
cord-012045-1cqqj84n	185	5	mechanism	mechanism	NN
cord-012045-1cqqj84n	185	6	of	of	IN
cord-012045-1cqqj84n	185	7	COVID-19	COVID-19	NNP
cord-012045-1cqqj84n	185	8	infection	infection	NN
cord-012045-1cqqj84n	185	9	has	have	VBZ
cord-012045-1cqqj84n	185	10	not	not	RB
cord-012045-1cqqj84n	185	11	been	be	VBN
cord-012045-1cqqj84n	185	12	well	well	RB
cord-012045-1cqqj84n	185	13	illustrated	illustrate	VBN
cord-012045-1cqqj84n	185	14	yet	yet	RB
cord-012045-1cqqj84n	185	15	.	.	.
cord-012045-1cqqj84n	186	1	From	from	IN
cord-012045-1cqqj84n	186	2	the	the	DT
cord-012045-1cqqj84n	186	3	biopsy	biopsy	NN
cord-012045-1cqqj84n	186	4	or	or	CC
cord-012045-1cqqj84n	186	5	autopsy	autopsy	JJ
cord-012045-1cqqj84n	186	6	of	of	IN
cord-012045-1cqqj84n	186	7	COVID-19	covid-19	JJ
cord-012045-1cqqj84n	186	8	patients	patient	NNS
cord-012045-1cqqj84n	186	9	,	,	,
cord-012045-1cqqj84n	186	10	diffuse	diffuse	VB
cord-012045-1cqqj84n	186	11	damage	damage	NN
cord-012045-1cqqj84n	186	12	of	of	IN
cord-012045-1cqqj84n	186	13	lung	lung	NN
cord-012045-1cqqj84n	186	14	parenchyma	parenchyma	NNS
cord-012045-1cqqj84n	186	15	has	have	VBZ
cord-012045-1cqqj84n	186	16	been	be	VBN
cord-012045-1cqqj84n	186	17	shown	show	VBN
cord-012045-1cqqj84n	186	18	[	[	-LRB-
cord-012045-1cqqj84n	186	19	102	102	CD
cord-012045-1cqqj84n	186	20	,	,	,
cord-012045-1cqqj84n	186	21	103	103	CD
cord-012045-1cqqj84n	186	22	]	]	-RRB-
cord-012045-1cqqj84n	186	23	.	.	.
cord-012045-1cqqj84n	187	1	Experts	expert	NNS
cord-012045-1cqqj84n	187	2	hypothesized	hypothesize	VBD
cord-012045-1cqqj84n	187	3	that	that	IN
cord-012045-1cqqj84n	187	4	SARS	SARS	NNP
cord-012045-1cqqj84n	187	5	-	-	HYPH
cord-012045-1cqqj84n	187	6	COV-2	COV-2	NNP
cord-012045-1cqqj84n	187	7	invasion	invasion	NN
cord-012045-1cqqj84n	187	8	severely	severely	RB
cord-012045-1cqqj84n	187	9	interrupts	interrupt	VBZ
cord-012045-1cqqj84n	187	10	the	the	DT
cord-012045-1cqqj84n	187	11	integrity	integrity	NN
cord-012045-1cqqj84n	187	12	of	of	IN
cord-012045-1cqqj84n	187	13	the	the	DT
cord-012045-1cqqj84n	187	14	airway	airway	NN
cord-012045-1cqqj84n	187	15	barrier	barrier	NN
cord-012045-1cqqj84n	187	16	,	,	,
cord-012045-1cqqj84n	187	17	thus	thus	RB
cord-012045-1cqqj84n	187	18	inducing	induce	VBG
cord-012045-1cqqj84n	187	19	aberrant	aberrant	JJ
cord-012045-1cqqj84n	187	20	inflammatory	inflammatory	JJ
cord-012045-1cqqj84n	187	21	release	release	NN
cord-012045-1cqqj84n	187	22	(	(	-LRB-
cord-012045-1cqqj84n	187	23	"	"	``
cord-012045-1cqqj84n	187	24	cytokine	cytokine	JJ
cord-012045-1cqqj84n	187	25	storm	storm	NN
cord-012045-1cqqj84n	187	26	"	"	''
cord-012045-1cqqj84n	187	27	)	)	-RRB-
cord-012045-1cqqj84n	187	28	and	and	CC
cord-012045-1cqqj84n	187	29	further	further	RB
cord-012045-1cqqj84n	187	30	worsening	worsen	VBG
cord-012045-1cqqj84n	187	31	the	the	DT
cord-012045-1cqqj84n	187	32	lung	lung	NN
cord-012045-1cqqj84n	187	33	injury	injury	NN
cord-012045-1cqqj84n	187	34	and	and	CC
cord-012045-1cqqj84n	187	35	microcirculation	microcirculation	NN
cord-012045-1cqqj84n	187	36	dysfunction	dysfunction	NN
cord-012045-1cqqj84n	187	37	,	,	,
cord-012045-1cqqj84n	187	38	resulting	result	VBG
cord-012045-1cqqj84n	187	39	in	in	IN
cord-012045-1cqqj84n	187	40	uncontrolled	uncontrolled	JJ
cord-012045-1cqqj84n	187	41	sepsis	sepsis	NN
cord-012045-1cqqj84n	187	42	in	in	IN
cord-012045-1cqqj84n	187	43	severe	severe	JJ
cord-012045-1cqqj84n	187	44	cases	case	NNS
cord-012045-1cqqj84n	187	45	[	[	-LRB-
cord-012045-1cqqj84n	187	46	104	104	CD
cord-012045-1cqqj84n	187	47	]	]	-RRB-
cord-012045-1cqqj84n	187	48	.	.	.
cord-012045-1cqqj84n	188	1	Whether	whether	IN
cord-012045-1cqqj84n	188	2	DUBs	dub	NNS
cord-012045-1cqqj84n	188	3	participate	participate	VBP
cord-012045-1cqqj84n	188	4	in	in	IN
cord-012045-1cqqj84n	188	5	the	the	DT
cord-012045-1cqqj84n	188	6	mechanism	mechanism	NN
cord-012045-1cqqj84n	188	7	of	of	IN
cord-012045-1cqqj84n	188	8	SARS	SARS	NNP
cord-012045-1cqqj84n	188	9	-	-	HYPH
cord-012045-1cqqj84n	188	10	COV-2	COV-2	NNP
cord-012045-1cqqj84n	188	11	infection	infection	NN
cord-012045-1cqqj84n	188	12	has	have	VBZ
cord-012045-1cqqj84n	188	13	not	not	RB
cord-012045-1cqqj84n	188	14	been	be	VBN
cord-012045-1cqqj84n	188	15	reported	report	VBN
cord-012045-1cqqj84n	188	16	.	.	.
cord-012045-1cqqj84n	189	1	The	the	DT
cord-012045-1cqqj84n	189	2	coronavirus	coronavirus	NN
cord-012045-1cqqj84n	189	3	family	family	NN
cord-012045-1cqqj84n	189	4	contains	contain	VBZ
cord-012045-1cqqj84n	189	5	six	six	CD
cord-012045-1cqqj84n	189	6	members	member	NNS
cord-012045-1cqqj84n	189	7	.	.	.
cord-012045-1cqqj84n	190	1	SARS	SARS	NNP
cord-012045-1cqqj84n	190	2	-	-	HYPH
cord-012045-1cqqj84n	190	3	CoV	CoV	NNP
cord-012045-1cqqj84n	190	4	and	and	CC
cord-012045-1cqqj84n	190	5	Middle	Middle	NNP
cord-012045-1cqqj84n	190	6	East	East	NNP
cord-012045-1cqqj84n	190	7	respiratory	respiratory	JJ
cord-012045-1cqqj84n	190	8	syndrome	syndrome	NN
cord-012045-1cqqj84n	190	9	coronavirus	coronavirus	NN
cord-012045-1cqqj84n	190	10	(	(	-LRB-
cord-012045-1cqqj84n	190	11	MERS	MERS	NNP
cord-012045-1cqqj84n	190	12	-	-	HYPH
cord-012045-1cqqj84n	190	13	CoV	CoV	NNP
cord-012045-1cqqj84n	190	14	)	)	-RRB-
cord-012045-1cqqj84n	190	15	are	be	VBP
cord-012045-1cqqj84n	190	16	the	the	DT
cord-012045-1cqqj84n	190	17	two	two	CD
cord-012045-1cqqj84n	190	18	members	member	NNS
cord-012045-1cqqj84n	190	19	that	that	WDT
cord-012045-1cqqj84n	190	20	have	have	VBP
cord-012045-1cqqj84n	190	21	brought	bring	VBN
cord-012045-1cqqj84n	190	22	an	an	DT
cord-012045-1cqqj84n	190	23	epidemic	epidemic	NN
cord-012045-1cqqj84n	190	24	in	in	IN
cord-012045-1cqqj84n	190	25	recent	recent	JJ
cord-012045-1cqqj84n	190	26	years	year	NNS
cord-012045-1cqqj84n	190	27	.	.	.
cord-012045-1cqqj84n	191	1	SARS	SARS	NNP
cord-012045-1cqqj84n	191	2	-	-	HYPH
cord-012045-1cqqj84n	191	3	CoV	CoV	NNP
cord-012045-1cqqj84n	191	4	and	and	CC
cord-012045-1cqqj84n	191	5	MERS	MERS	NNP
cord-012045-1cqqj84n	191	6	-	-	HYPH
cord-012045-1cqqj84n	191	7	CoV	CoV	NNP
cord-012045-1cqqj84n	191	8	,	,	,
cord-012045-1cqqj84n	191	9	containing	contain	VBG
cord-012045-1cqqj84n	191	10	the	the	DT
cord-012045-1cqqj84n	191	11	papain	papain	NN
cord-012045-1cqqj84n	191	12	-	-	HYPH
cord-012045-1cqqj84n	191	13	like	like	JJ
cord-012045-1cqqj84n	191	14	cysteine	cysteine	NN
cord-012045-1cqqj84n	191	15	proteases	protease	NNS
cord-012045-1cqqj84n	191	16	(	(	-LRB-
cord-012045-1cqqj84n	191	17	PLpro	PLpro	NNP
cord-012045-1cqqj84n	191	18	)	)	-RRB-
cord-012045-1cqqj84n	191	19	,	,	,
cord-012045-1cqqj84n	191	20	termed	term	VBN
cord-012045-1cqqj84n	192	1	SARS	SARS	NNP
cord-012045-1cqqj84n	192	2	-	-	HYPH
cord-012045-1cqqj84n	192	3	CoVPLpro	CoVPLpro	NNP
cord-012045-1cqqj84n	192	4	and	and	CC
cord-012045-1cqqj84n	192	5	MERS	MERS	NNP
cord-012045-1cqqj84n	192	6	-	-	HYPH
cord-012045-1cqqj84n	192	7	CoVPLpro	CoVPLpro	NNP
cord-012045-1cqqj84n	192	8	respectively	respectively	RB
cord-012045-1cqqj84n	192	9	,	,	,
cord-012045-1cqqj84n	192	10	are	be	VBP
cord-012045-1cqqj84n	192	11	antagonists	antagonist	NNS
cord-012045-1cqqj84n	192	12	of	of	IN
cord-012045-1cqqj84n	192	13	the	the	DT
cord-012045-1cqqj84n	192	14	host	host	NN
cord-012045-1cqqj84n	192	15	antiviral	antiviral	JJ
cord-012045-1cqqj84n	192	16	immune	immune	JJ
cord-012045-1cqqj84n	192	17	response	response	NN
cord-012045-1cqqj84n	192	18	as	as	IN
cord-012045-1cqqj84n	192	19	they	-PRON-	PRP
cord-012045-1cqqj84n	192	20	remove	remove	VBP
cord-012045-1cqqj84n	192	21	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	192	22	and	and	CC
cord-012045-1cqqj84n	193	1	its	-PRON-	PRP$
cord-012045-1cqqj84n	193	2	modifier	modifier	NN
cord-012045-1cqqj84n	193	3	interferon	interferon	NN
cord-012045-1cqqj84n	193	4	-	-	HYPH
cord-012045-1cqqj84n	193	5	stimulated	stimulate	VBN
cord-012045-1cqqj84n	193	6	gene	gene	NN
cord-012045-1cqqj84n	193	7	15	15	CD
cord-012045-1cqqj84n	193	8	(	(	-LRB-
cord-012045-1cqqj84n	193	9	ISG15	isg15	NN
cord-012045-1cqqj84n	193	10	)	)	-RRB-
cord-012045-1cqqj84n	193	11	signals	signal	NNS
cord-012045-1cqqj84n	193	12	from	from	IN
cord-012045-1cqqj84n	193	13	host	host	NN
cord-012045-1cqqj84n	193	14	cell	cell	NN
cord-012045-1cqqj84n	193	15	factors	factor	NNS
cord-012045-1cqqj84n	193	16	[	[	-LRB-
cord-012045-1cqqj84n	193	17	105	105	CD
cord-012045-1cqqj84n	193	18	,	,	,
cord-012045-1cqqj84n	193	19	106	106	CD
cord-012045-1cqqj84n	193	20	]	]	-RRB-
cord-012045-1cqqj84n	193	21	.	.	.
cord-012045-1cqqj84n	194	1	Whether	whether	IN
cord-012045-1cqqj84n	194	2	such	such	PDT
cord-012045-1cqqj84n	194	3	a	a	DT
cord-012045-1cqqj84n	194	4	protease	protease	NN
cord-012045-1cqqj84n	194	5	encoded	encode	VBN
cord-012045-1cqqj84n	194	6	by	by	IN
cord-012045-1cqqj84n	194	7	the	the	DT
cord-012045-1cqqj84n	194	8	SARS	SARS	NNP
cord-012045-1cqqj84n	194	9	-	-	HYPH
cord-012045-1cqqj84n	194	10	CoV-2	CoV-2	NNP
cord-012045-1cqqj84n	194	11	genome	genome	NN
cord-012045-1cqqj84n	194	12	exists	exist	VBZ
cord-012045-1cqqj84n	194	13	has	have	VBZ
cord-012045-1cqqj84n	194	14	not	not	RB
cord-012045-1cqqj84n	194	15	been	be	VBN
cord-012045-1cqqj84n	194	16	reported	report	VBN
cord-012045-1cqqj84n	194	17	,	,	,
cord-012045-1cqqj84n	194	18	which	which	WDT
cord-012045-1cqqj84n	194	19	might	may	MD
cord-012045-1cqqj84n	194	20	expand	expand	VB
cord-012045-1cqqj84n	194	21	the	the	DT
cord-012045-1cqqj84n	194	22	field	field	NN
cord-012045-1cqqj84n	194	23	of	of	IN
cord-012045-1cqqj84n	194	24	SARS	SARS	NNP
cord-012045-1cqqj84n	194	25	-	-	HYPH
cord-012045-1cqqj84n	194	26	CoV-2	CoV-2	NNP
cord-012045-1cqqj84n	194	27	study	study	NN
cord-012045-1cqqj84n	194	28	.	.	.
cord-012045-1cqqj84n	195	1	Furthermore	furthermore	RB
cord-012045-1cqqj84n	195	2	,	,	,
cord-012045-1cqqj84n	195	3	human	human	JJ
cord-012045-1cqqj84n	195	4	DUBs	dub	NNS
cord-012045-1cqqj84n	195	5	might	may	MD
cord-012045-1cqqj84n	195	6	be	be	VB
cord-012045-1cqqj84n	195	7	potential	potential	JJ
cord-012045-1cqqj84n	195	8	targets	target	NNS
cord-012045-1cqqj84n	195	9	for	for	IN
cord-012045-1cqqj84n	195	10	SARS	SARS	NNP
cord-012045-1cqqj84n	195	11	-	-	HYPH
cord-012045-1cqqj84n	195	12	CoV-2	CoV-2	NNP
cord-012045-1cqqj84n	195	13	invasion	invasion	NN
cord-012045-1cqqj84n	195	14	.	.	.
cord-012045-1cqqj84n	196	1	We	-PRON-	PRP
cord-012045-1cqqj84n	196	2	scanned	scan	VBD
cord-012045-1cqqj84n	196	3	the	the	DT
cord-012045-1cqqj84n	196	4	related	relate	VBN
cord-012045-1cqqj84n	196	5	dataset	dataset	NN
cord-012045-1cqqj84n	196	6	of	of	IN
cord-012045-1cqqj84n	196	7	genes	gene	NNS
cord-012045-1cqqj84n	196	8	and	and	CC
cord-012045-1cqqj84n	196	9	proteins	protein	NNS
cord-012045-1cqqj84n	196	10	in	in	IN
cord-012045-1cqqj84n	196	11	COVID-19	COVID-19	NNP
cord-012045-1cqqj84n	196	12	and	and	CC
cord-012045-1cqqj84n	196	13	the	the	DT
cord-012045-1cqqj84n	196	14	SARS	SARS	NNP
cord-012045-1cqqj84n	196	15	-	-	HYPH
cord-012045-1cqqj84n	196	16	CoV-2	CoV-2	NNP
cord-012045-1cqqj84n	196	17	infected	infected	JJ
cord-012045-1cqqj84n	196	18	cells	cell	NNS
cord-012045-1cqqj84n	196	19	.	.	.
cord-012045-1cqqj84n	197	1	Data	datum	NNS
cord-012045-1cqqj84n	197	2	showed	show	VBD
cord-012045-1cqqj84n	197	3	that	that	IN
cord-012045-1cqqj84n	197	4	a	a	DT
cord-012045-1cqqj84n	197	5	majority	majority	NN
cord-012045-1cqqj84n	197	6	of	of	IN
cord-012045-1cqqj84n	197	7	DUBs	dub	NNS
cord-012045-1cqqj84n	197	8	are	be	VBP
cord-012045-1cqqj84n	197	9	decreased	decrease	VBN
cord-012045-1cqqj84n	197	10	in	in	IN
cord-012045-1cqqj84n	197	11	human	human	JJ
cord-012045-1cqqj84n	197	12	iPSC	iPSC	NNS
cord-012045-1cqqj84n	197	13	-	-	HYPH
cord-012045-1cqqj84n	197	14	cardiomyocytes	cardiomyocyte	NNS
cord-012045-1cqqj84n	197	15	infected	infect	VBN
cord-012045-1cqqj84n	197	16	with	with	IN
cord-012045-1cqqj84n	197	17	SARS	SARS	NNP
cord-012045-1cqqj84n	197	18	-	-	HYPH
cord-012045-1cqqj84n	197	19	COV-2	COV-2	NNP
cord-012045-1cqqj84n	197	20	via	via	IN
cord-012045-1cqqj84n	197	21	RNA	rna	NN
cord-012045-1cqqj84n	197	22	-	-	HYPH
cord-012045-1cqqj84n	197	23	sequencing	sequence	VBG
cord-012045-1cqqj84n	197	24	[	[	-LRB-
cord-012045-1cqqj84n	197	25	107	107	CD
cord-012045-1cqqj84n	197	26	]	]	-RRB-
cord-012045-1cqqj84n	197	27	.	.	.
cord-012045-1cqqj84n	198	1	In	in	IN
cord-012045-1cqqj84n	198	2	ACE2	ACE2	NNP
cord-012045-1cqqj84n	198	3	positive	positive	JJ
cord-012045-1cqqj84n	198	4	type	type	NN
cord-012045-1cqqj84n	198	5	II	II	NNP
cord-012045-1cqqj84n	198	6	pneumocytes	pneumocytes	NNPS
cord-012045-1cqqj84n	198	7	,	,	,
cord-012045-1cqqj84n	198	8	a	a	DT
cord-012045-1cqqj84n	198	9	number	number	NN
cord-012045-1cqqj84n	198	10	of	of	IN
cord-012045-1cqqj84n	198	11	USPs	usp	NNS
cord-012045-1cqqj84n	198	12	including	include	VBG
cord-012045-1cqqj84n	198	13	USP11	USP11	NNP
cord-012045-1cqqj84n	198	14	and	and	CC
cord-012045-1cqqj84n	198	15	USP38	USP38	NNP
cord-012045-1cqqj84n	198	16	are	be	VBP
cord-012045-1cqqj84n	198	17	elevated	elevate	VBN
cord-012045-1cqqj84n	198	18	compared	compare	VBN
cord-012045-1cqqj84n	198	19	to	to	IN
cord-012045-1cqqj84n	198	20	ACE2	ACE2	NNP
cord-012045-1cqqj84n	198	21	negative	negative	JJ
cord-012045-1cqqj84n	198	22	cells	cell	NNS
cord-012045-1cqqj84n	198	23	using	use	VBG
cord-012045-1cqqj84n	198	24	next	next	JJ
cord-012045-1cqqj84n	198	25	generation	generation	NN
cord-012045-1cqqj84n	198	26	sequencing	sequence	VBG
cord-012045-1cqqj84n	198	27	[	[	-LRB-
cord-012045-1cqqj84n	198	28	108	108	CD
cord-012045-1cqqj84n	198	29	]	]	-RRB-
cord-012045-1cqqj84n	198	30	.	.	.
cord-012045-1cqqj84n	199	1	SARS	SARS	NNP
cord-012045-1cqqj84n	199	2	-	-	HYPH
cord-012045-1cqqj84n	199	3	CoV-2	CoV-2	NNP
cord-012045-1cqqj84n	199	4	spike	spike	NN
cord-012045-1cqqj84n	199	5	(	(	-LRB-
cord-012045-1cqqj84n	199	6	S	s	NN
cord-012045-1cqqj84n	199	7	)	)	-RRB-
cord-012045-1cqqj84n	199	8	protein	protein	NN
cord-012045-1cqqj84n	199	9	invades	invade	VBZ
cord-012045-1cqqj84n	199	10	human	human	JJ
cord-012045-1cqqj84n	199	11	tissue	tissue	NN
cord-012045-1cqqj84n	199	12	through	through	IN
cord-012045-1cqqj84n	199	13	binding	bind	VBG
cord-012045-1cqqj84n	199	14	angiotensin	angiotensin	NN
cord-012045-1cqqj84n	199	15	-	-	HYPH
cord-012045-1cqqj84n	199	16	converting	convert	VBG
cord-012045-1cqqj84n	199	17	enzyme	enzyme	NN
cord-012045-1cqqj84n	199	18	2	2	CD
cord-012045-1cqqj84n	199	19	(	(	-LRB-
cord-012045-1cqqj84n	199	20	ACE2	ACE2	NNP
cord-012045-1cqqj84n	199	21	)	)	-RRB-
cord-012045-1cqqj84n	199	22	,	,	,
cord-012045-1cqqj84n	199	23	which	which	WDT
cord-012045-1cqqj84n	199	24	reminds	remind	VBZ
cord-012045-1cqqj84n	199	25	us	-PRON-	PRP
cord-012045-1cqqj84n	199	26	that	that	IN
cord-012045-1cqqj84n	199	27	USPs	USPs	NNP
cord-012045-1cqqj84n	199	28	might	may	MD
cord-012045-1cqqj84n	199	29	play	play	VB
cord-012045-1cqqj84n	199	30	an	an	DT
cord-012045-1cqqj84n	199	31	important	important	JJ
cord-012045-1cqqj84n	199	32	role	role	NN
cord-012045-1cqqj84n	199	33	in	in	IN
cord-012045-1cqqj84n	199	34	COVID-19	COVID-19	NNP
cord-012045-1cqqj84n	199	35	development	development	NN
cord-012045-1cqqj84n	199	36	.	.	.
cord-012045-1cqqj84n	200	1	However	however	RB
cord-012045-1cqqj84n	200	2	,	,	,
cord-012045-1cqqj84n	200	3	in	in	IN
cord-012045-1cqqj84n	200	4	the	the	DT
cord-012045-1cqqj84n	200	5	sera	sera	NNP
cord-012045-1cqqj84n	200	6	of	of	IN
cord-012045-1cqqj84n	200	7	COVID-19	COVID-19	NNP
cord-012045-1cqqj84n	200	8	patients	patient	NNS
cord-012045-1cqqj84n	200	9	,	,	,
cord-012045-1cqqj84n	200	10	no	no	DT
cord-012045-1cqqj84n	200	11	DUBs	dub	NNS
cord-012045-1cqqj84n	200	12	have	have	VBP
cord-012045-1cqqj84n	200	13	been	be	VBN
cord-012045-1cqqj84n	200	14	found	find	VBN
cord-012045-1cqqj84n	200	15	through	through	IN
cord-012045-1cqqj84n	200	16	proteomics	proteomic	NNS
cord-012045-1cqqj84n	200	17	[	[	-LRB-
cord-012045-1cqqj84n	200	18	109	109	CD
cord-012045-1cqqj84n	200	19	]	]	-RRB-
cord-012045-1cqqj84n	200	20	.	.	.
cord-012045-1cqqj84n	201	1	In	in	IN
cord-012045-1cqqj84n	201	2	all	all	DT
cord-012045-1cqqj84n	201	3	,	,	,
cord-012045-1cqqj84n	201	4	the	the	DT
cord-012045-1cqqj84n	201	5	above	above	JJ
cord-012045-1cqqj84n	201	6	data	datum	NNS
cord-012045-1cqqj84n	201	7	revealed	reveal	VBD
cord-012045-1cqqj84n	201	8	that	that	IN
cord-012045-1cqqj84n	201	9	DUBs	dub	NNS
cord-012045-1cqqj84n	201	10	might	may	MD
cord-012045-1cqqj84n	201	11	be	be	VB
cord-012045-1cqqj84n	201	12	involved	involve	VBN
cord-012045-1cqqj84n	201	13	in	in	IN
cord-012045-1cqqj84n	201	14	the	the	DT
cord-012045-1cqqj84n	201	15	mechanism	mechanism	NN
cord-012045-1cqqj84n	201	16	of	of	IN
cord-012045-1cqqj84n	201	17	SARS	SARS	NNP
cord-012045-1cqqj84n	201	18	-	-	HYPH
cord-012045-1cqqj84n	201	19	CoV-2	CoV-2	NNP
cord-012045-1cqqj84n	201	20	infections	infection	NNS
cord-012045-1cqqj84n	201	21	,	,	,
cord-012045-1cqqj84n	201	22	but	but	CC
cord-012045-1cqqj84n	201	23	further	further	JJ
cord-012045-1cqqj84n	201	24	studies	study	NNS
cord-012045-1cqqj84n	201	25	are	be	VBP
cord-012045-1cqqj84n	201	26	still	still	RB
cord-012045-1cqqj84n	201	27	urged	urge	VBN
cord-012045-1cqqj84n	201	28	to	to	TO
cord-012045-1cqqj84n	201	29	explore	explore	VB
cord-012045-1cqqj84n	201	30	the	the	DT
cord-012045-1cqqj84n	201	31	function	function	NN
cord-012045-1cqqj84n	201	32	of	of	IN
cord-012045-1cqqj84n	201	33	DUBs	dub	NNS
cord-012045-1cqqj84n	201	34	in	in	IN
cord-012045-1cqqj84n	201	35	COVID-19	COVID-19	NNP
cord-012045-1cqqj84n	201	36	.	.	.
cord-012045-1cqqj84n	202	1	The	the	DT
cord-012045-1cqqj84n	202	2	USP	USP	NNP
cord-012045-1cqqj84n	202	3	subfamily	subfamily	NN
cord-012045-1cqqj84n	202	4	contains	contain	VBZ
cord-012045-1cqqj84n	202	5	the	the	DT
cord-012045-1cqqj84n	202	6	majority	majority	NN
cord-012045-1cqqj84n	202	7	of	of	IN
cord-012045-1cqqj84n	202	8	DUBs	dub	NNS
cord-012045-1cqqj84n	202	9	encoded	encode	VBN
cord-012045-1cqqj84n	202	10	by	by	IN
cord-012045-1cqqj84n	202	11	the	the	DT
cord-012045-1cqqj84n	202	12	human	human	JJ
cord-012045-1cqqj84n	202	13	genome	genome	NN
cord-012045-1cqqj84n	202	14	,	,	,
cord-012045-1cqqj84n	202	15	which	which	WDT
cord-012045-1cqqj84n	202	16	are	be	VBP
cord-012045-1cqqj84n	202	17	the	the	DT
cord-012045-1cqqj84n	202	18	most	most	RBS
cord-012045-1cqqj84n	202	19	diversified	diversified	JJ
cord-012045-1cqqj84n	202	20	members	member	NNS
cord-012045-1cqqj84n	202	21	within	within	IN
cord-012045-1cqqj84n	202	22	the	the	DT
cord-012045-1cqqj84n	202	23	DUB	DUB	NNP
cord-012045-1cqqj84n	202	24	family	family	NN
cord-012045-1cqqj84n	202	25	[	[	-LRB-
cord-012045-1cqqj84n	202	26	110	110	CD
cord-012045-1cqqj84n	202	27	]	]	-RRB-
cord-012045-1cqqj84n	202	28	[	[	-LRB-
cord-012045-1cqqj84n	202	29	111	111	CD
cord-012045-1cqqj84n	202	30	]	]	-RRB-
cord-012045-1cqqj84n	202	31	[	[	-LRB-
cord-012045-1cqqj84n	202	32	112	112	CD
cord-012045-1cqqj84n	202	33	]	]	-RRB-
cord-012045-1cqqj84n	202	34	.	.	.
cord-012045-1cqqj84n	203	1	The	the	DT
cord-012045-1cqqj84n	203	2	most	most	RBS
cord-012045-1cqqj84n	203	3	studied	study	VBN
cord-012045-1cqqj84n	203	4	DUB	DUB	NNP
cord-012045-1cqqj84n	203	5	family	family	NN
cord-012045-1cqqj84n	203	6	member	member	NN
cord-012045-1cqqj84n	203	7	in	in	IN
cord-012045-1cqqj84n	203	8	USPs	USPs	NNP
cord-012045-1cqqj84n	203	9	is	be	VBZ
cord-012045-1cqqj84n	203	10	cylindromatosis	cylindromatosis	NN
cord-012045-1cqqj84n	203	11	(	(	-LRB-
cord-012045-1cqqj84n	203	12	CYLD	CYLD	NNP
cord-012045-1cqqj84n	203	13	)	)	-RRB-
cord-012045-1cqqj84n	203	14	.	.	.
cord-012045-1cqqj84n	204	1	CYLD	CYLD	NNP
cord-012045-1cqqj84n	204	2	was	be	VBD
cord-012045-1cqqj84n	204	3	originally	originally	RB
cord-012045-1cqqj84n	204	4	identified	identify	VBN
cord-012045-1cqqj84n	204	5	as	as	IN
cord-012045-1cqqj84n	204	6	a	a	DT
cord-012045-1cqqj84n	204	7	tumor	tumor	NN
cord-012045-1cqqj84n	204	8	suppressor	suppressor	NN
cord-012045-1cqqj84n	204	9	,	,	,
cord-012045-1cqqj84n	204	10	where	where	WRB
cord-012045-1cqqj84n	204	11	loss	loss	NN
cord-012045-1cqqj84n	204	12	of	of	IN
cord-012045-1cqqj84n	204	13	which	which	WDT
cord-012045-1cqqj84n	204	14	causes	cause	VBZ
cord-012045-1cqqj84n	204	15	a	a	DT
cord-012045-1cqqj84n	204	16	benign	benign	JJ
cord-012045-1cqqj84n	204	17	human	human	JJ
cord-012045-1cqqj84n	204	18	syndrome	syndrome	NN
cord-012045-1cqqj84n	204	19	CYLD	CYLD	NNP
cord-012045-1cqqj84n	204	20	[	[	-LRB-
cord-012045-1cqqj84n	204	21	113	113	CD
cord-012045-1cqqj84n	204	22	]	]	-RRB-
cord-012045-1cqqj84n	204	23	.	.	.
cord-012045-1cqqj84n	205	1	With	with	IN
cord-012045-1cqqj84n	205	2	sequence	sequence	NN
cord-012045-1cqqj84n	205	3	homology	homology	NN
cord-012045-1cqqj84n	205	4	to	to	IN
cord-012045-1cqqj84n	205	5	the	the	DT
cord-012045-1cqqj84n	205	6	catalytic	catalytic	JJ
cord-012045-1cqqj84n	205	7	domain	domain	NN
cord-012045-1cqqj84n	205	8	of	of	IN
cord-012045-1cqqj84n	205	9	ubiquitin	ubiquitin	JJ
cord-012045-1cqqj84n	205	10	carboxy	carboxy	JJ
cord-012045-1cqqj84n	205	11	-	-	HYPH
cord-012045-1cqqj84n	205	12	terminal	terminal	NN
cord-012045-1cqqj84n	205	13	hydrolases	hydrolase	NNS
cord-012045-1cqqj84n	205	14	(	(	-LRB-
cord-012045-1cqqj84n	205	15	UCH	UCH	NNP
cord-012045-1cqqj84n	205	16	)	)	-RRB-
cord-012045-1cqqj84n	205	17	,	,	,
cord-012045-1cqqj84n	205	18	CYLD	CYLD	NNP
cord-012045-1cqqj84n	205	19	cleaves	cleave	VBZ
cord-012045-1cqqj84n	205	20	K63-linked	K63-linked	NNP
cord-012045-1cqqj84n	205	21	polyubiquitin	polyubiquitin	NNP
cord-012045-1cqqj84n	205	22	chains	chain	NNS
cord-012045-1cqqj84n	205	23	off	off	IN
cord-012045-1cqqj84n	205	24	its	-PRON-	PRP$
cord-012045-1cqqj84n	205	25	target	target	NN
cord-012045-1cqqj84n	205	26	proteins	protein	NNS
cord-012045-1cqqj84n	205	27	[	[	-LRB-
cord-012045-1cqqj84n	205	28	114	114	CD
cord-012045-1cqqj84n	205	29	]	]	-RRB-
cord-012045-1cqqj84n	205	30	[	[	-LRB-
cord-012045-1cqqj84n	205	31	115	115	CD
cord-012045-1cqqj84n	205	32	]	]	-RRB-
cord-012045-1cqqj84n	205	33	[	[	-LRB-
cord-012045-1cqqj84n	205	34	116	116	CD
cord-012045-1cqqj84n	205	35	]	]	-RRB-
cord-012045-1cqqj84n	205	36	.	.	.
cord-012045-1cqqj84n	206	1	CYLD	CYLD	NNP
cord-012045-1cqqj84n	206	2	is	be	VBZ
cord-012045-1cqqj84n	206	3	proven	prove	VBN
cord-012045-1cqqj84n	206	4	to	to	TO
cord-012045-1cqqj84n	206	5	be	be	VB
cord-012045-1cqqj84n	206	6	induced	induce	VBN
cord-012045-1cqqj84n	206	7	by	by	IN
cord-012045-1cqqj84n	206	8	Gram	gram	NN
cord-012045-1cqqj84n	206	9	-	-	HYPH
cord-012045-1cqqj84n	206	10	negative	negative	JJ
cord-012045-1cqqj84n	206	11	and	and	CC
cord-012045-1cqqj84n	206	12	Gram	gram	NN
cord-012045-1cqqj84n	206	13	-	-	HYPH
cord-012045-1cqqj84n	206	14	positive	positive	JJ
cord-012045-1cqqj84n	206	15	bacterial	bacterial	JJ
cord-012045-1cqqj84n	206	16	pathogens	pathogen	NNS
cord-012045-1cqqj84n	206	17	or	or	CC
cord-012045-1cqqj84n	206	18	their	-PRON-	PRP$
cord-012045-1cqqj84n	206	19	products	product	NNS
cord-012045-1cqqj84n	206	20	[	[	-LRB-
cord-012045-1cqqj84n	206	21	45	45	CD
cord-012045-1cqqj84n	206	22	,	,	,
cord-012045-1cqqj84n	206	23	46	46	CD
cord-012045-1cqqj84n	206	24	,	,	,
cord-012045-1cqqj84n	206	25	48	48	CD
cord-012045-1cqqj84n	206	26	,	,	,
cord-012045-1cqqj84n	206	27	117	117	CD
cord-012045-1cqqj84n	206	28	]	]	-RRB-
cord-012045-1cqqj84n	206	29	.	.	.
cord-012045-1cqqj84n	207	1	The	the	DT
cord-012045-1cqqj84n	207	2	transcription	transcription	NN
cord-012045-1cqqj84n	207	3	factor	factor	NN
cord-012045-1cqqj84n	207	4	NF	nf	NN
cord-012045-1cqqj84n	207	5	-	-	HYPH
cord-012045-1cqqj84n	207	6	κB	κB	NNP
cord-012045-1cqqj84n	207	7	activated	activate	VBN
cord-012045-1cqqj84n	207	8	by	by	IN
cord-012045-1cqqj84n	207	9	bacteria	bacteria	NNS
cord-012045-1cqqj84n	207	10	is	be	VBZ
cord-012045-1cqqj84n	207	11	essential	essential	JJ
cord-012045-1cqqj84n	207	12	for	for	IN
cord-012045-1cqqj84n	207	13	induction	induction	NN
cord-012045-1cqqj84n	207	14	of	of	IN
cord-012045-1cqqj84n	207	15	CYLD	CYLD	NNP
cord-012045-1cqqj84n	207	16	,	,	,
cord-012045-1cqqj84n	207	17	in	in	IN
cord-012045-1cqqj84n	207	18	turn	turn	NN
cord-012045-1cqqj84n	207	19	,	,	,
cord-012045-1cqqj84n	207	20	induced	induce	VBD
cord-012045-1cqqj84n	207	21	CYLD	CYLD	NNP
cord-012045-1cqqj84n	207	22	negatively	negatively	RB
cord-012045-1cqqj84n	207	23	regulates	regulate	VBZ
cord-012045-1cqqj84n	207	24	the	the	DT
cord-012045-1cqqj84n	207	25	bacteria	bacteria	NNS
cord-012045-1cqqj84n	207	26	induced	induce	VBN
cord-012045-1cqqj84n	208	1	NF	NF	NNP
cord-012045-1cqqj84n	208	2	-	-	HYPH
cord-012045-1cqqj84n	208	3	κB	κB	NNP
cord-012045-1cqqj84n	208	4	signaling	signal	VBG
cord-012045-1cqqj84n	208	5	[	[	-LRB-
cord-012045-1cqqj84n	208	6	46	46	CD
cord-012045-1cqqj84n	208	7	,	,	,
cord-012045-1cqqj84n	208	8	117	117	CD
cord-012045-1cqqj84n	208	9	]	]	-RRB-
cord-012045-1cqqj84n	208	10	.	.	.
cord-012045-1cqqj84n	209	1	CYLD	CYLD	NNP
cord-012045-1cqqj84n	209	2	deubiquitinates	deubiquitinates	NNP
cord-012045-1cqqj84n	210	1	TRAF6	TRAF6	NNP
cord-012045-1cqqj84n	210	2	and	and	CC
cord-012045-1cqqj84n	210	3	TRAF7	TRAF7	NNP
cord-012045-1cqqj84n	211	1	to	to	TO
cord-012045-1cqqj84n	211	2	negatively	negatively	RB
cord-012045-1cqqj84n	211	3	regulate	regulate	VB
cord-012045-1cqqj84n	211	4	peptidoglycan	peptidoglycan	NN
cord-012045-1cqqj84n	211	5	-	-	HYPH
cord-012045-1cqqj84n	211	6	induced	induce	VBN
cord-012045-1cqqj84n	211	7	Toll	Toll	NNP
cord-012045-1cqqj84n	211	8	-	-	HYPH
cord-012045-1cqqj84n	211	9	Like	like	JJ
cord-012045-1cqqj84n	211	10	receptor	receptor	NN
cord-012045-1cqqj84n	211	11	2	2	CD
cord-012045-1cqqj84n	211	12	(	(	-LRB-
cord-012045-1cqqj84n	211	13	TLR2	TLR2	NNP
cord-012045-1cqqj84n	211	14	)	)	-RRB-
cord-012045-1cqqj84n	211	15	signaling	signaling	NN
cord-012045-1cqqj84n	211	16	and	and	CC
cord-012045-1cqqj84n	211	17	inflammation	inflammation	NN
cord-012045-1cqqj84n	211	18	[	[	-LRB-
cord-012045-1cqqj84n	211	19	45	45	CD
cord-012045-1cqqj84n	211	20	]	]	-RRB-
cord-012045-1cqqj84n	211	21	.	.	.
cord-012045-1cqqj84n	212	1	CYLD	CYLD	NNP
cord-012045-1cqqj84n	212	2	is	be	VBZ
cord-012045-1cqqj84n	212	3	also	also	RB
cord-012045-1cqqj84n	212	4	highly	highly	RB
cord-012045-1cqqj84n	212	5	induced	induce	VBN
cord-012045-1cqqj84n	212	6	by	by	IN
cord-012045-1cqqj84n	212	7	pneumolysin	pneumolysin	NNP
cord-012045-1cqqj84n	212	8	(	(	-LRB-
cord-012045-1cqqj84n	212	9	PLY	PLY	NNP
cord-012045-1cqqj84n	212	10	)	)	-RRB-
cord-012045-1cqqj84n	212	11	.	.	.
cord-012045-1cqqj84n	213	1	CYLD	CYLD	NNP
cord-012045-1cqqj84n	213	2	deficiency	deficiency	NN
cord-012045-1cqqj84n	213	3	protects	protect	VBZ
cord-012045-1cqqj84n	213	4	mice	mouse	NNS
cord-012045-1cqqj84n	213	5	from	from	IN
cord-012045-1cqqj84n	213	6	acute	acute	JJ
cord-012045-1cqqj84n	213	7	lung	lung	NN
cord-012045-1cqqj84n	213	8	injury	injury	NN
cord-012045-1cqqj84n	213	9	in	in	IN
cord-012045-1cqqj84n	213	10	lethal	lethal	JJ
cord-012045-1cqqj84n	213	11	Streptococcus	streptococcus	NN
cord-012045-1cqqj84n	213	12	pneumoniae	pneumoniae	NN
cord-012045-1cqqj84n	213	13	infections	infection	NNS
cord-012045-1cqqj84n	213	14	by	by	IN
cord-012045-1cqqj84n	213	15	inhibiting	inhibit	VBG
cord-012045-1cqqj84n	213	16	plasminogen	plasminogen	NN
cord-012045-1cqqj84n	213	17	activator	activator	NN
cord-012045-1cqqj84n	213	18	inhibitor-1	inhibitor-1	NNP
cord-012045-1cqqj84n	213	19	(	(	-LRB-
cord-012045-1cqqj84n	213	20	PAI-1	PAI-1	NNP
cord-012045-1cqqj84n	213	21	)	)	-RRB-
cord-012045-1cqqj84n	213	22	expression	expression	NN
cord-012045-1cqqj84n	213	23	[	[	-LRB-
cord-012045-1cqqj84n	213	24	44	44	CD
cord-012045-1cqqj84n	213	25	,	,	,
cord-012045-1cqqj84n	213	26	48	48	CD
cord-012045-1cqqj84n	213	27	]	]	-RRB-
cord-012045-1cqqj84n	213	28	.	.	.
cord-012045-1cqqj84n	214	1	Furthermore	furthermore	RB
cord-012045-1cqqj84n	214	2	,	,	,
cord-012045-1cqqj84n	214	3	evidence	evidence	NN
cord-012045-1cqqj84n	214	4	shows	show	VBZ
cord-012045-1cqqj84n	214	5	that	that	IN
cord-012045-1cqqj84n	214	6	CYLD	CYLD	NNP
cord-012045-1cqqj84n	214	7	negatively	negatively	RB
cord-012045-1cqqj84n	214	8	regulates	regulate	VBZ
cord-012045-1cqqj84n	214	9	the	the	DT
cord-012045-1cqqj84n	214	10	S.	S.	NNP
cord-012045-1cqqj84n	214	11	pneumoniae	pneumoniae	NN
cord-012045-1cqqj84n	214	12	-	-	HYPH
cord-012045-1cqqj84n	214	13	induced	induce	VBN
cord-012045-1cqqj84n	214	14	nuclear	nuclear	JJ
cord-012045-1cqqj84n	214	15	factor	factor	NN
cord-012045-1cqqj84n	214	16	of	of	IN
cord-012045-1cqqj84n	214	17	activated	activate	VBN
cord-012045-1cqqj84n	214	18	T	t	NN
cord-012045-1cqqj84n	214	19	cells	cell	NNS
cord-012045-1cqqj84n	214	20	(	(	-LRB-
cord-012045-1cqqj84n	215	1	NFAT)signaling	NFAT)signaling	NNP
cord-012045-1cqqj84n	215	2	pathway	pathway	NN
cord-012045-1cqqj84n	215	3	by	by	IN
cord-012045-1cqqj84n	215	4	deubiquitinating	deubiquitinate	VBG
cord-012045-1cqqj84n	216	1	TGF	TGF	NNP
cord-012045-1cqqj84n	216	2	-	-	HYPH
cord-012045-1cqqj84n	216	3	β	β	NN
cord-012045-1cqqj84n	216	4	-	-	HYPH
cord-012045-1cqqj84n	216	5	activated	activate	VBN
cord-012045-1cqqj84n	216	6	kinase	kinase	NN
cord-012045-1cqqj84n	216	7	1(TAK1	1(tak1	CD
cord-012045-1cqqj84n	216	8	)	)	-RRB-
cord-012045-1cqqj84n	216	9	[	[	-LRB-
cord-012045-1cqqj84n	216	10	43	43	CD
cord-012045-1cqqj84n	216	11	]	]	-RRB-
cord-012045-1cqqj84n	216	12	.	.	.
cord-012045-1cqqj84n	217	1	In	in	IN
cord-012045-1cqqj84n	217	2	contrast	contrast	NN
cord-012045-1cqqj84n	217	3	,	,	,
cord-012045-1cqqj84n	217	4	CYLD(-/-	CYLD(-/-	NNP
cord-012045-1cqqj84n	217	5	)	)	-RRB-
cord-012045-1cqqj84n	217	6	mice	mouse	NNS
cord-012045-1cqqj84n	217	7	are	be	VBP
cord-012045-1cqqj84n	217	8	hypersusceptible	hypersusceptible	JJ
cord-012045-1cqqj84n	217	9	to	to	IN
cord-012045-1cqqj84n	217	10	Escherichia	Escherichia	NNP
cord-012045-1cqqj84n	217	11	coli	coli	VBZ
cord-012045-1cqqj84n	217	12	pneumonia	pneumonia	NN
cord-012045-1cqqj84n	217	13	with	with	IN
cord-012045-1cqqj84n	217	14	enhanced	enhanced	JJ
cord-012045-1cqqj84n	217	15	NF	nf	NN
cord-012045-1cqqj84n	217	16	-	-	HYPH
cord-012045-1cqqj84n	217	17	κB	κb	CD
cord-012045-1cqqj84n	217	18	activation	activation	NN
cord-012045-1cqqj84n	217	19	[	[	-LRB-
cord-012045-1cqqj84n	217	20	118	118	CD
cord-012045-1cqqj84n	217	21	]	]	-RRB-
cord-012045-1cqqj84n	217	22	.	.	.
cord-012045-1cqqj84n	218	1	Perhaps	perhaps	RB
cord-012045-1cqqj84n	218	2	different	different	JJ
cord-012045-1cqqj84n	218	3	pathogens	pathogen	NNS
cord-012045-1cqqj84n	218	4	may	may	MD
cord-012045-1cqqj84n	218	5	use	use	VB
cord-012045-1cqqj84n	218	6	distinct	distinct	JJ
cord-012045-1cqqj84n	218	7	mechanisms	mechanism	NNS
cord-012045-1cqqj84n	218	8	to	to	TO
cord-012045-1cqqj84n	218	9	promote	promote	VB
cord-012045-1cqqj84n	218	10	lung	lung	NN
cord-012045-1cqqj84n	218	11	inflammation	inflammation	NN
cord-012045-1cqqj84n	218	12	.	.	.
cord-012045-1cqqj84n	219	1	In	in	IN
cord-012045-1cqqj84n	219	2	the	the	DT
cord-012045-1cqqj84n	219	3	late	late	JJ
cord-012045-1cqqj84n	219	4	stage	stage	NN
cord-012045-1cqqj84n	219	5	of	of	IN
cord-012045-1cqqj84n	219	6	bacterial	bacterial	JJ
cord-012045-1cqqj84n	219	7	infection	infection	NN
cord-012045-1cqqj84n	219	8	,	,	,
cord-012045-1cqqj84n	219	9	CYLD	CYLD	NNP
cord-012045-1cqqj84n	219	10	exhibits	exhibit	VBZ
cord-012045-1cqqj84n	219	11	negative	negative	JJ
cord-012045-1cqqj84n	219	12	effects	effect	NNS
cord-012045-1cqqj84n	219	13	on	on	IN
cord-012045-1cqqj84n	219	14	injury	injury	NN
cord-012045-1cqqj84n	219	15	-	-	HYPH
cord-012045-1cqqj84n	219	16	induced	induce	VBN
cord-012045-1cqqj84n	219	17	lung	lung	NN
cord-012045-1cqqj84n	219	18	fibrotic	fibrotic	JJ
cord-012045-1cqqj84n	219	19	response	response	NN
cord-012045-1cqqj84n	219	20	by	by	IN
cord-012045-1cqqj84n	219	21	inhibiting	inhibit	VBG
cord-012045-1cqqj84n	219	22	TGF	TGF	NNP
cord-012045-1cqqj84n	219	23	-	-	HYPH
cord-012045-1cqqj84n	219	24	β	β	NN
cord-012045-1cqqj84n	219	25	-	-	HYPH
cord-012045-1cqqj84n	219	26	signaling	signal	VBG
cord-012045-1cqqj84n	219	27	[	[	-LRB-
cord-012045-1cqqj84n	219	28	47	47	CD
cord-012045-1cqqj84n	219	29	]	]	-RRB-
cord-012045-1cqqj84n	219	30	.	.	.
cord-012045-1cqqj84n	220	1	These	these	DT
cord-012045-1cqqj84n	220	2	discoveries	discovery	NNS
cord-012045-1cqqj84n	220	3	indicated	indicate	VBD
cord-012045-1cqqj84n	220	4	that	that	IN
cord-012045-1cqqj84n	220	5	CYLD	CYLD	NNP
cord-012045-1cqqj84n	220	6	might	may	MD
cord-012045-1cqqj84n	220	7	possess	possess	VB
cord-012045-1cqqj84n	220	8	a	a	DT
cord-012045-1cqqj84n	220	9	potential	potential	JJ
cord-012045-1cqqj84n	220	10	drug	drug	NN
cord-012045-1cqqj84n	220	11	target	target	NN
cord-012045-1cqqj84n	220	12	for	for	IN
cord-012045-1cqqj84n	220	13	the	the	DT
cord-012045-1cqqj84n	220	14	treatment	treatment	NN
cord-012045-1cqqj84n	220	15	of	of	IN
cord-012045-1cqqj84n	220	16	bacterial	bacterial	JJ
cord-012045-1cqqj84n	220	17	infection	infection	NN
cord-012045-1cqqj84n	220	18	pneumonia	pneumonia	NN
cord-012045-1cqqj84n	220	19	.	.	.
cord-012045-1cqqj84n	221	1	USP7	USP7	NNP
cord-012045-1cqqj84n	222	1	(	(	-LRB-
cord-012045-1cqqj84n	222	2	HAUSP)is	hausp)is	IN
cord-012045-1cqqj84n	222	3	originally	originally	RB
cord-012045-1cqqj84n	222	4	identified	identify	VBN
cord-012045-1cqqj84n	222	5	as	as	IN
cord-012045-1cqqj84n	222	6	a	a	DT
cord-012045-1cqqj84n	222	7	viral	viral	JJ
cord-012045-1cqqj84n	222	8	binding	bind	VBG
cord-012045-1cqqj84n	222	9	protein	protein	NN
cord-012045-1cqqj84n	222	10	that	that	WDT
cord-012045-1cqqj84n	222	11	preferentially	preferentially	RB
cord-012045-1cqqj84n	222	12	cleaves	cleave	VBZ
cord-012045-1cqqj84n	222	13	K11-	K11-	NNP
cord-012045-1cqqj84n	222	14	,	,	,
cord-012045-1cqqj84n	222	15	K63-and	k63-and	JJ
cord-012045-1cqqj84n	222	16	K48-linked	K48-linked	NNP
cord-012045-1cqqj84n	222	17	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	222	18	chains	chain	NNS
cord-012045-1cqqj84n	222	19	[	[	-LRB-
cord-012045-1cqqj84n	222	20	119	119	CD
cord-012045-1cqqj84n	222	21	,	,	,
cord-012045-1cqqj84n	222	22	120	120	CD
cord-012045-1cqqj84n	222	23	]	]	-RRB-
cord-012045-1cqqj84n	222	24	.	.	.
cord-012045-1cqqj84n	223	1	USP7	USP7	NNP
cord-012045-1cqqj84n	223	2	is	be	VBZ
cord-012045-1cqqj84n	223	3	involved	involve	VBN
cord-012045-1cqqj84n	223	4	in	in	IN
cord-012045-1cqqj84n	223	5	viral	viral	JJ
cord-012045-1cqqj84n	223	6	infection	infection	NN
cord-012045-1cqqj84n	223	7	by	by	IN
cord-012045-1cqqj84n	223	8	targeting	target	VBG
cord-012045-1cqqj84n	223	9	virus	virus	NN
cord-012045-1cqqj84n	223	10	related	relate	VBN
cord-012045-1cqqj84n	223	11	protein	protein	NN
cord-012045-1cqqj84n	223	12	to	to	TO
cord-012045-1cqqj84n	223	13	modulate	modulate	VB
cord-012045-1cqqj84n	223	14	virus	virus	NN
cord-012045-1cqqj84n	223	15	replication	replication	NN
cord-012045-1cqqj84n	223	16	and	and	CC
cord-012045-1cqqj84n	223	17	production	production	NN
cord-012045-1cqqj84n	223	18	[	[	-LRB-
cord-012045-1cqqj84n	223	19	49	49	CD
cord-012045-1cqqj84n	223	20	]	]	-RRB-
cord-012045-1cqqj84n	223	21	[	[	-LRB-
cord-012045-1cqqj84n	223	22	50	50	CD
cord-012045-1cqqj84n	223	23	]	]	-RRB-
cord-012045-1cqqj84n	223	24	[	[	-LRB-
cord-012045-1cqqj84n	223	25	51	51	CD
cord-012045-1cqqj84n	223	26	]	]	-RRB-
cord-012045-1cqqj84n	223	27	.	.	.
cord-012045-1cqqj84n	224	1	USP7	USP7	NNP
cord-012045-1cqqj84n	224	2	is	be	VBZ
cord-012045-1cqqj84n	224	3	reported	report	VBN
cord-012045-1cqqj84n	224	4	to	to	TO
cord-012045-1cqqj84n	224	5	deubiquitinate	deubiquitinate	VB
cord-012045-1cqqj84n	224	6	and	and	CC
cord-012045-1cqqj84n	224	7	stabilize	stabilize	VB
cord-012045-1cqqj84n	224	8	NF	NF	NNP
cord-012045-1cqqj84n	224	9	-	-	HYPH
cord-012045-1cqqj84n	224	10	κB	κB	NNP
cord-012045-1cqqj84n	224	11	to	to	TO
cord-012045-1cqqj84n	224	12	increase	increase	VB
cord-012045-1cqqj84n	224	13	its	-PRON-	PRP$
cord-012045-1cqqj84n	224	14	transcriptional	transcriptional	JJ
cord-012045-1cqqj84n	224	15	activity	activity	NN
cord-012045-1cqqj84n	224	16	in	in	IN
cord-012045-1cqqj84n	224	17	TLR	TLR	NNP
cord-012045-1cqqj84n	224	18	-	-	HYPH
cord-012045-1cqqj84n	224	19	induced	induce	VBN
cord-012045-1cqqj84n	224	20	inflammatory	inflammatory	JJ
cord-012045-1cqqj84n	224	21	gene	gene	NN
cord-012045-1cqqj84n	224	22	expression	expression	NN
cord-012045-1cqqj84n	224	23	[	[	-LRB-
cord-012045-1cqqj84n	224	24	39	39	CD
cord-012045-1cqqj84n	224	25	]	]	-RRB-
cord-012045-1cqqj84n	224	26	.	.	.
cord-012045-1cqqj84n	225	1	Furthermore	furthermore	RB
cord-012045-1cqqj84n	225	2	,	,	,
cord-012045-1cqqj84n	225	3	USP10	usp10	FW
cord-012045-1cqqj84n	225	4	fine	fine	RB
cord-012045-1cqqj84n	225	5	-	-	HYPH
cord-012045-1cqqj84n	225	6	tunes	tune	NNS
cord-012045-1cqqj84n	225	7	NOTCH	notch	NN
cord-012045-1cqqj84n	225	8	signaling	signal	VBG
cord-012045-1cqqj84n	225	9	in	in	IN
cord-012045-1cqqj84n	225	10	angiogenic	angiogenic	JJ
cord-012045-1cqqj84n	225	11	sprouting	sprout	VBG
cord-012045-1cqqj84n	225	12	by	by	IN
cord-012045-1cqqj84n	225	13	deubiquitinatingNOTCH1	deubiquitinatingNOTCH1	NNP
cord-012045-1cqqj84n	225	14	intracellular	intracellular	JJ
cord-012045-1cqqj84n	225	15	domain	domain	NN
cord-012045-1cqqj84n	225	16	(	(	-LRB-
cord-012045-1cqqj84n	225	17	NICD1	NICD1	VBN
cord-012045-1cqqj84n	225	18	)	)	-RRB-
cord-012045-1cqqj84n	225	19	to	to	TO
cord-012045-1cqqj84n	225	20	slow	slow	VB
cord-012045-1cqqj84n	225	21	down	down	RP
cord-012045-1cqqj84n	225	22	its	-PRON-	PRP$
cord-012045-1cqqj84n	225	23	turnover	turnover	NN
cord-012045-1cqqj84n	225	24	of	of	IN
cord-012045-1cqqj84n	225	25	the	the	DT
cord-012045-1cqqj84n	225	26	short	short	RB
cord-012045-1cqqj84n	225	27	-	-	HYPH
cord-012045-1cqqj84n	225	28	lived	live	VBN
cord-012045-1cqqj84n	225	29	form	form	NN
cord-012045-1cqqj84n	225	30	of	of	IN
cord-012045-1cqqj84n	225	31	the	the	DT
cord-012045-1cqqj84n	225	32	activated	activate	VBN
cord-012045-1cqqj84n	225	33	NOTCH1	notch1	JJ
cord-012045-1cqqj84n	225	34	receptor	receptor	NN
cord-012045-1cqqj84n	225	35	[	[	-LRB-
cord-012045-1cqqj84n	225	36	53	53	CD
cord-012045-1cqqj84n	225	37	]	]	-RRB-
cord-012045-1cqqj84n	225	38	.	.	.
cord-012045-1cqqj84n	226	1	UPS13	UPS13	NNP
cord-012045-1cqqj84n	226	2	is	be	VBZ
cord-012045-1cqqj84n	226	3	also	also	RB
cord-012045-1cqqj84n	226	4	reported	report	VBN
cord-012045-1cqqj84n	226	5	to	to	TO
cord-012045-1cqqj84n	226	6	regulate	regulate	VB
cord-012045-1cqqj84n	226	7	antiviral	antiviral	JJ
cord-012045-1cqqj84n	226	8	responses	response	NNS
cord-012045-1cqqj84n	226	9	,	,	,
cord-012045-1cqqj84n	226	10	however	however	RB
cord-012045-1cqqj84n	226	11	,	,	,
cord-012045-1cqqj84n	226	12	its	-PRON-	PRP$
cord-012045-1cqqj84n	226	13	function	function	NN
cord-012045-1cqqj84n	226	14	is	be	VBZ
cord-012045-1cqqj84n	226	15	controversial	controversial	JJ
cord-012045-1cqqj84n	226	16	.	.	.
cord-012045-1cqqj84n	227	1	USP13	USP13	NNP
cord-012045-1cqqj84n	227	2	is	be	VBZ
cord-012045-1cqqj84n	227	3	considered	consider	VBN
cord-012045-1cqqj84n	227	4	to	to	TO
cord-012045-1cqqj84n	227	5	promote	promote	VB
cord-012045-1cqqj84n	227	6	IFN	IFN	NNP
cord-012045-1cqqj84n	227	7	signaling	signal	VBG
cord-012045-1cqqj84n	227	8	and	and	CC
cord-012045-1cqqj84n	227	9	play	play	VB
cord-012045-1cqqj84n	227	10	an	an	DT
cord-012045-1cqqj84n	227	11	antiviral	antiviral	JJ
cord-012045-1cqqj84n	227	12	role	role	NN
cord-012045-1cqqj84n	227	13	by	by	IN
cord-012045-1cqqj84n	227	14	stabilizing	stabilize	VBG
cord-012045-1cqqj84n	227	15	STAT1	stat1	XX
cord-012045-1cqqj84n	227	16	[	[	-LRB-
cord-012045-1cqqj84n	227	17	55	55	CD
cord-012045-1cqqj84n	227	18	]	]	-RRB-
cord-012045-1cqqj84n	227	19	.	.	.
cord-012045-1cqqj84n	228	1	Nevertheless	nevertheless	RB
cord-012045-1cqqj84n	228	2	,	,	,
cord-012045-1cqqj84n	228	3	USP13	usp13	JJ
cord-012045-1cqqj84n	228	4	deficiency	deficiency	NN
cord-012045-1cqqj84n	228	5	enhances	enhance	VBZ
cord-012045-1cqqj84n	228	6	antiviral	antiviral	JJ
cord-012045-1cqqj84n	228	7	responses	response	NNS
cord-012045-1cqqj84n	228	8	through	through	IN
cord-012045-1cqqj84n	228	9	deubiquitinating	deubiquitinate	VBG
cord-012045-1cqqj84n	228	10	stimulator	stimulator	NN
cord-012045-1cqqj84n	228	11	of	of	IN
cord-012045-1cqqj84n	228	12	interferon	interferon	NN
cord-012045-1cqqj84n	228	13	(	(	-LRB-
cord-012045-1cqqj84n	228	14	STING	sting	NN
cord-012045-1cqqj84n	228	15	)	)	-RRB-
cord-012045-1cqqj84n	228	16	[	[	-LRB-
cord-012045-1cqqj84n	228	17	56	56	CD
cord-012045-1cqqj84n	228	18	]	]	-RRB-
cord-012045-1cqqj84n	228	19	.	.	.
cord-012045-1cqqj84n	229	1	During	during	IN
cord-012045-1cqqj84n	229	2	bacterial	bacterial	JJ
cord-012045-1cqqj84n	229	3	infection	infection	NN
cord-012045-1cqqj84n	229	4	,	,	,
cord-012045-1cqqj84n	229	5	USP15	USP15	NNP
cord-012045-1cqqj84n	229	6	loses	lose	VBZ
cord-012045-1cqqj84n	229	7	its	-PRON-	PRP$
cord-012045-1cqqj84n	229	8	activity	activity	NN
cord-012045-1cqqj84n	229	9	for	for	IN
cord-012045-1cqqj84n	229	10	IκBα	IκBα	NNP
cord-012045-1cqqj84n	229	11	deubiquitination	deubiquitination	NN
cord-012045-1cqqj84n	229	12	by	by	IN
cord-012045-1cqqj84n	229	13	interacting	interact	VBG
cord-012045-1cqqj84n	229	14	with	with	IN
cord-012045-1cqqj84n	229	15	E3	E3	NNP
cord-012045-1cqqj84n	229	16	Ub	Ub	NNP
cord-012045-1cqqj84n	229	17	-	-	HYPH
cord-012045-1cqqj84n	229	18	ligase	ligase	NN
cord-012045-1cqqj84n	229	19	Hrd1	Hrd1	NNP
cord-012045-1cqqj84n	229	20	to	to	TO
cord-012045-1cqqj84n	229	21	promote	promote	VB
cord-012045-1cqqj84n	229	22	TLR4-induced	TLR4-induced	NNP
cord-012045-1cqqj84n	229	23	inflammation	inflammation	NN
cord-012045-1cqqj84n	229	24	[	[	-LRB-
cord-012045-1cqqj84n	229	25	57	57	CD
cord-012045-1cqqj84n	229	26	]	]	-RRB-
cord-012045-1cqqj84n	229	27	.	.	.
cord-012045-1cqqj84n	230	1	USP17	USP17	NNP
cord-012045-1cqqj84n	230	2	mediates	mediate	VBZ
cord-012045-1cqqj84n	230	3	deubiquitination	deubiquitination	NN
cord-012045-1cqqj84n	230	4	and	and	CC
cord-012045-1cqqj84n	230	5	stabilization	stabilization	NN
cord-012045-1cqqj84n	230	6	of	of	IN
cord-012045-1cqqj84n	230	7	HDAC2	hdac2	NN
cord-012045-1cqqj84n	230	8	in	in	IN
cord-012045-1cqqj84n	230	9	cigarette	cigarette	NN
cord-012045-1cqqj84n	230	10	smoke	smoke	NN
cord-012045-1cqqj84n	230	11	extract	extract	NN
cord-012045-1cqqj84n	230	12	-	-	HYPH
cord-012045-1cqqj84n	230	13	induced	induce	VBN
cord-012045-1cqqj84n	230	14	inflammation	inflammation	NN
cord-012045-1cqqj84n	230	15	[	[	-LRB-
cord-012045-1cqqj84n	230	16	58	58	CD
cord-012045-1cqqj84n	230	17	]	]	-RRB-
cord-012045-1cqqj84n	230	18	.	.	.
cord-012045-1cqqj84n	231	1	USP19	USP19	NNP
cord-012045-1cqqj84n	231	2	also	also	RB
cord-012045-1cqqj84n	231	3	preserves	preserve	VBZ
cord-012045-1cqqj84n	231	4	a	a	DT
cord-012045-1cqqj84n	231	5	negative	negative	JJ
cord-012045-1cqqj84n	231	6	effect	effect	NN
cord-012045-1cqqj84n	231	7	on	on	IN
cord-012045-1cqqj84n	231	8	TNF	TNF	NNP
cord-012045-1cqqj84n	231	9	-	-	HYPH
cord-012045-1cqqj84n	231	10	α	α	NNP
cord-012045-1cqqj84n	231	11	-	-	HYPH
cord-012045-1cqqj84n	231	12	and	and	CC
cord-012045-1cqqj84n	231	13	IL-1β	il-1β	RB
cord-012045-1cqqj84n	231	14	-	-	HYPH
cord-012045-1cqqj84n	231	15	triggered	trigger	VBN
cord-012045-1cqqj84n	231	16	NF	nf	NN
cord-012045-1cqqj84n	231	17	-	-	HYPH
cord-012045-1cqqj84n	231	18	κB	κb	CD
cord-012045-1cqqj84n	231	19	activation	activation	NN
cord-012045-1cqqj84n	231	20	by	by	IN
cord-012045-1cqqj84n	231	21	deubiquitinating	deubiquitinate	VBG
cord-012045-1cqqj84n	231	22	TAK1	TAK1	NNP
cord-012045-1cqqj84n	231	23	[	[	-LRB-
cord-012045-1cqqj84n	231	24	60	60	CD
cord-012045-1cqqj84n	231	25	]	]	-RRB-
cord-012045-1cqqj84n	231	26	.	.	.
cord-012045-1cqqj84n	232	1	USP19	USP19	NNP
cord-012045-1cqqj84n	232	2	interacts	interact	VBZ
cord-012045-1cqqj84n	232	3	with	with	IN
cord-012045-1cqqj84n	232	4	TIR	TIR	NNP
cord-012045-1cqqj84n	232	5	domain	domain	NN
cord-012045-1cqqj84n	232	6	-	-	HYPH
cord-012045-1cqqj84n	232	7	containing	contain	VBG
cord-012045-1cqqj84n	232	8	adaptor	adaptor	NN
cord-012045-1cqqj84n	232	9	inducing	induce	VBG
cord-012045-1cqqj84n	232	10	interferon	interferon	NN
cord-012045-1cqqj84n	232	11	-	-	HYPH
cord-012045-1cqqj84n	232	12	β	β	NN
cord-012045-1cqqj84n	232	13	(	(	-LRB-
cord-012045-1cqqj84n	232	14	TRIF	TRIF	NNP
cord-012045-1cqqj84n	232	15	)	)	-RRB-
cord-012045-1cqqj84n	232	16	,	,	,
cord-012045-1cqqj84n	232	17	and	and	CC
cord-012045-1cqqj84n	232	18	thus	thus	RB
cord-012045-1cqqj84n	232	19	impairs	impair	VBZ
cord-012045-1cqqj84n	232	20	its	-PRON-	PRP$
cord-012045-1cqqj84n	232	21	recruitment	recruitment	NN
cord-012045-1cqqj84n	232	22	to	to	IN
cord-012045-1cqqj84n	232	23	TLR3/4	TLR3/4	NNP
cord-012045-1cqqj84n	232	24	[	[	-LRB-
cord-012045-1cqqj84n	232	25	61	61	CD
cord-012045-1cqqj84n	232	26	]	]	-RRB-
cord-012045-1cqqj84n	232	27	.	.	.
cord-012045-1cqqj84n	233	1	USP19	USP19	.
cord-012045-1cqqj84n	234	1	deficient	deficient	JJ
cord-012045-1cqqj84n	234	2	mice	mouse	NNS
cord-012045-1cqqj84n	234	3	produce	produce	VBP
cord-012045-1cqqj84n	234	4	exacerbated	exacerbate	VBN
cord-012045-1cqqj84n	234	5	inflammatory	inflammatory	JJ
cord-012045-1cqqj84n	234	6	cytokines	cytokine	NNS
cord-012045-1cqqj84n	234	7	and	and	CC
cord-012045-1cqqj84n	234	8	are	be	VBP
cord-012045-1cqqj84n	234	9	more	more	RBR
cord-012045-1cqqj84n	234	10	susceptible	susceptible	JJ
cord-012045-1cqqj84n	234	11	to	to	IN
cord-012045-1cqqj84n	234	12	septicemia	septicemia	NN
cord-012045-1cqqj84n	234	13	death	death	NN
cord-012045-1cqqj84n	234	14	[	[	-LRB-
cord-012045-1cqqj84n	234	15	60	60	CD
cord-012045-1cqqj84n	234	16	,	,	,
cord-012045-1cqqj84n	234	17	61	61	CD
cord-012045-1cqqj84n	234	18	]	]	-RRB-
cord-012045-1cqqj84n	234	19	.	.	.
cord-012045-1cqqj84n	235	1	USP19	USP19	NNP
cord-012045-1cqqj84n	235	2	affects	affect	VBZ
cord-012045-1cqqj84n	235	3	DDX58	DDX58	NNP
cord-012045-1cqqj84n	235	4	/	/	SYM
cord-012045-1cqqj84n	235	5	RIG	rig	NN
cord-012045-1cqqj84n	235	6	-	-	HYPH
cord-012045-1cqqj84n	235	7	I	i	NN
cord-012045-1cqqj84n	235	8	-	-	HYPH
cord-012045-1cqqj84n	235	9	mediated	mediate	VBN
cord-012045-1cqqj84n	235	10	type	type	NN
cord-012045-1cqqj84n	236	1	I	-PRON-	PRP
cord-012045-1cqqj84n	236	2	interferon	interferon	RB
cord-012045-1cqqj84n	236	3	signaling	signal	VBG
cord-012045-1cqqj84n	236	4	through	through	IN
cord-012045-1cqqj84n	236	5	ubiquitinating	ubiquitinate	VBG
cord-012045-1cqqj84n	236	6	BECN1	BECN1	NNP
cord-012045-1cqqj84n	236	7	and	and	CC
cord-012045-1cqqj84n	236	8	promoting	promote	VBG
cord-012045-1cqqj84n	236	9	the	the	DT
cord-012045-1cqqj84n	236	10	formation	formation	NN
cord-012045-1cqqj84n	236	11	of	of	IN
cord-012045-1cqqj84n	236	12	autophagosomes	autophagosomes	NNP
cord-012045-1cqqj84n	236	13	[	[	-LRB-
cord-012045-1cqqj84n	236	14	62	62	CD
cord-012045-1cqqj84n	236	15	]	]	-RRB-
cord-012045-1cqqj84n	236	16	.	.	.
cord-012045-1cqqj84n	237	1	USP25	USP25	NNP
cord-012045-1cqqj84n	237	2	plays	play	VBZ
cord-012045-1cqqj84n	237	3	a	a	DT
cord-012045-1cqqj84n	237	4	protective	protective	JJ
cord-012045-1cqqj84n	237	5	role	role	NN
cord-012045-1cqqj84n	237	6	in	in	IN
cord-012045-1cqqj84n	237	7	virus	virus	NN
cord-012045-1cqqj84n	237	8	or	or	CC
cord-012045-1cqqj84n	237	9	bacterial	bacterial	JJ
cord-012045-1cqqj84n	237	10	infection	infection	NN
cord-012045-1cqqj84n	237	11	.	.	.
cord-012045-1cqqj84n	238	1	Several	several	JJ
cord-012045-1cqqj84n	238	2	studies	study	NNS
cord-012045-1cqqj84n	238	3	showed	show	VBD
cord-012045-1cqqj84n	238	4	that	that	IN
cord-012045-1cqqj84n	238	5	USP25	USP25	NNP
cord-012045-1cqqj84n	238	6	negatively	negatively	RB
cord-012045-1cqqj84n	238	7	regulates	regulate	VBZ
cord-012045-1cqqj84n	238	8	virus	virus	NN
cord-012045-1cqqj84n	238	9	-	-	HYPH
cord-012045-1cqqj84n	238	10	induced	induce	VBN
cord-012045-1cqqj84n	238	11	type	type	NN
cord-012045-1cqqj84n	239	1	I	-PRON-	PRP
cord-012045-1cqqj84n	239	2	IFN	IFN	NNP
cord-012045-1cqqj84n	239	3	signaling	signal	VBG
cord-012045-1cqqj84n	239	4	by	by	IN
cord-012045-1cqqj84n	239	5	stabilizing	stabilize	VBG
cord-012045-1cqqj84n	239	6	TRAF2	TRAF2	NNP
cord-012045-1cqqj84n	239	7	,	,	,
cord-012045-1cqqj84n	240	1	TRAF3	TRAF3	NNP
cord-012045-1cqqj84n	240	2	and	and	CC
cord-012045-1cqqj84n	240	3	TRAF6	TRAF6	NNP
cord-012045-1cqqj84n	241	1	[	[	-LRB-
cord-012045-1cqqj84n	241	2	64	64	CD
cord-012045-1cqqj84n	241	3	,	,	,
cord-012045-1cqqj84n	241	4	65	65	CD
cord-012045-1cqqj84n	241	5	,	,	,
cord-012045-1cqqj84n	241	6	75	75	CD
cord-012045-1cqqj84n	241	7	,	,	,
cord-012045-1cqqj84n	241	8	87	87	CD
cord-012045-1cqqj84n	241	9	,	,	,
cord-012045-1cqqj84n	241	10	[	[	-LRB-
cord-012045-1cqqj84n	241	11	121	121	CD
cord-012045-1cqqj84n	241	12	]	]	-RRB-
cord-012045-1cqqj84n	241	13	[	[	-LRB-
cord-012045-1cqqj84n	241	14	122	122	CD
cord-012045-1cqqj84n	241	15	]	]	-RRB-
cord-012045-1cqqj84n	241	16	[	[	-LRB-
cord-012045-1cqqj84n	241	17	123	123	CD
cord-012045-1cqqj84n	241	18	]	]	-RRB-
cord-012045-1cqqj84n	241	19	[	[	-LRB-
cord-012045-1cqqj84n	241	20	124	124	CD
cord-012045-1cqqj84n	241	21	]	]	-RRB-
cord-012045-1cqqj84n	241	22	.	.	.
cord-012045-1cqqj84n	242	1	Furthermore	furthermore	RB
cord-012045-1cqqj84n	242	2	,	,	,
cord-012045-1cqqj84n	242	3	USP25	USP25	NNP
cord-012045-1cqqj84n	242	4	inhibits	inhibit	VBZ
cord-012045-1cqqj84n	242	5	TLR4-activated	TLR4-activated	NNP
cord-012045-1cqqj84n	242	6	innate	innate	JJ
cord-012045-1cqqj84n	242	7	immunity	immunity	NN
cord-012045-1cqqj84n	242	8	via	via	IN
cord-012045-1cqqj84n	242	9	removing	remove	VBG
cord-012045-1cqqj84n	242	10	K48	K48	NNP
cord-012045-1cqqj84n	242	11	ubiquitination	ubiquitination	NN
cord-012045-1cqqj84n	242	12	of	of	IN
cord-012045-1cqqj84n	242	13	TRAF3	TRAF3	NNP
cord-012045-1cqqj84n	242	14	[	[	-LRB-
cord-012045-1cqqj84n	242	15	63	63	CD
cord-012045-1cqqj84n	242	16	]	]	-RRB-
cord-012045-1cqqj84n	242	17	.	.	.
cord-012045-1cqqj84n	243	1	USP25	USP25	NNP
cord-012045-1cqqj84n	244	1	deficient	deficient	JJ
cord-012045-1cqqj84n	244	2	mice	mouse	NNS
cord-012045-1cqqj84n	244	3	have	have	VBP
cord-012045-1cqqj84n	244	4	been	be	VBN
cord-012045-1cqqj84n	244	5	shown	show	VBN
cord-012045-1cqqj84n	244	6	to	to	TO
cord-012045-1cqqj84n	244	7	be	be	VB
cord-012045-1cqqj84n	244	8	more	more	RBR
cord-012045-1cqqj84n	244	9	susceptible	susceptible	JJ
cord-012045-1cqqj84n	244	10	to	to	IN
cord-012045-1cqqj84n	244	11	virus	virus	NN
cord-012045-1cqqj84n	244	12	infection	infection	NN
cord-012045-1cqqj84n	244	13	and	and	CC
cord-012045-1cqqj84n	244	14	LPS	LPS	NNP
cord-012045-1cqqj84n	244	15	-	-	HYPH
cord-012045-1cqqj84n	244	16	induced	induce	VBN
cord-012045-1cqqj84n	244	17	septic	septic	JJ
cord-012045-1cqqj84n	244	18	shock	shock	NN
cord-012045-1cqqj84n	244	19	[	[	-LRB-
cord-012045-1cqqj84n	244	20	63	63	CD
cord-012045-1cqqj84n	244	21	,	,	,
cord-012045-1cqqj84n	244	22	65	65	CD
cord-012045-1cqqj84n	244	23	]	]	-RRB-
cord-012045-1cqqj84n	245	1	.IL-17-mediated	.IL-17-mediated	.
cord-012045-1cqqj84n	246	1	inflammation	inflammation	NN
cord-012045-1cqqj84n	246	2	is	be	VBZ
cord-012045-1cqqj84n	246	3	also	also	RB
cord-012045-1cqqj84n	246	4	attenuated	attenuate	VBN
cord-012045-1cqqj84n	246	5	by	by	IN
cord-012045-1cqqj84n	246	6	USP25	USP25	NNP
cord-012045-1cqqj84n	246	7	through	through	IN
cord-012045-1cqqj84n	246	8	TRAF5	TRAF5	NNP
cord-012045-1cqqj84n	246	9	and	and	CC
cord-012045-1cqqj84n	246	10	TRAF6	TRAF6	NNP
cord-012045-1cqqj84n	246	11	deubiquitination	deubiquitination	NNP
cord-012045-1cqqj84n	246	12	[	[	-LRB-
cord-012045-1cqqj84n	246	13	66	66	CD
cord-012045-1cqqj84n	246	14	]	]	-RRB-
cord-012045-1cqqj84n	246	15	.	.	.
cord-012045-1cqqj84n	247	1	The	the	DT
cord-012045-1cqqj84n	247	2	anti	anti	JJ
cord-012045-1cqqj84n	247	3	-	-	JJ
cord-012045-1cqqj84n	247	4	malarial	malarial	JJ
cord-012045-1cqqj84n	247	5	drug	drug	NN
cord-012045-1cqqj84n	247	6	chloroquine	chloroquine	NN
cord-012045-1cqqj84n	247	7	is	be	VBZ
cord-012045-1cqqj84n	247	8	suggested	suggest	VBN
cord-012045-1cqqj84n	247	9	to	to	TO
cord-012045-1cqqj84n	247	10	alleviate	alleviate	VB
cord-012045-1cqqj84n	247	11	LPS	LPS	NNP
cord-012045-1cqqj84n	247	12	-	-	HYPH
cord-012045-1cqqj84n	247	13	induced	induce	VBN
cord-012045-1cqqj84n	247	14	inflammation	inflammation	NN
cord-012045-1cqqj84n	247	15	by	by	IN
cord-012045-1cqqj84n	247	16	up	up	NN
cord-012045-1cqqj84n	247	17	regulatingUSP25	regulatingUSP25	NNP
cord-012045-1cqqj84n	247	18	in	in	IN
cord-012045-1cqqj84n	247	19	macrophages	macrophage	NNS
cord-012045-1cqqj84n	247	20	[	[	-LRB-
cord-012045-1cqqj84n	247	21	125	125	CD
cord-012045-1cqqj84n	247	22	]	]	-RRB-
cord-012045-1cqqj84n	247	23	.	.	.
cord-012045-1cqqj84n	248	1	The	the	DT
cord-012045-1cqqj84n	248	2	OTU	OTU	NNP
cord-012045-1cqqj84n	248	3	family	family	NN
cord-012045-1cqqj84n	248	4	DUBs	dub	NNS
cord-012045-1cqqj84n	248	5	can	can	MD
cord-012045-1cqqj84n	248	6	be	be	VB
cord-012045-1cqqj84n	248	7	divided	divide	VBN
cord-012045-1cqqj84n	248	8	into	into	IN
cord-012045-1cqqj84n	248	9	four	four	CD
cord-012045-1cqqj84n	248	10	subfamilies	subfamily	NNS
cord-012045-1cqqj84n	248	11	,	,	,
cord-012045-1cqqj84n	248	12	including	include	VBG
cord-012045-1cqqj84n	248	13	OTULINs	OTULINs	NNP
cord-012045-1cqqj84n	248	14	(	(	-LRB-
cord-012045-1cqqj84n	248	15	OTULIN	OTULIN	NNP
cord-012045-1cqqj84n	248	16	and	and	CC
cord-012045-1cqqj84n	248	17	FAM105A	FAM105A	NNP
cord-012045-1cqqj84n	248	18	)	)	-RRB-
cord-012045-1cqqj84n	248	19	,	,	,
cord-012045-1cqqj84n	248	20	OTUBs	OTUBs	NNP
cord-012045-1cqqj84n	248	21	/	/	SYM
cord-012045-1cqqj84n	248	22	Otubains	Otubains	NNP
cord-012045-1cqqj84n	248	23	(	(	-LRB-
cord-012045-1cqqj84n	248	24	OTUB1	OTUB1	NNP
cord-012045-1cqqj84n	248	25	and	and	CC
cord-012045-1cqqj84n	248	26	OTUB2	OTUB2	NNP
cord-012045-1cqqj84n	248	27	)	)	-RRB-
cord-012045-1cqqj84n	248	28	,	,	,
cord-012045-1cqqj84n	248	29	OTUDs	OTUDs	NNP
cord-012045-1cqqj84n	248	30	(	(	-LRB-
cord-012045-1cqqj84n	248	31	OTUD1	otud1	NN
cord-012045-1cqqj84n	248	32	,	,	,
cord-012045-1cqqj84n	249	1	OTUD2	OTUD2	NNP
cord-012045-1cqqj84n	249	2	/	/	SYM
cord-012045-1cqqj84n	249	3	YOD1	YOD1	NNP
cord-012045-1cqqj84n	249	4	,	,	,
cord-012045-1cqqj84n	249	5	OTUD3	otud3	NN
cord-012045-1cqqj84n	249	6	,	,	,
cord-012045-1cqqj84n	249	7	OTUD4	OTUD4	NNP
cord-012045-1cqqj84n	249	8	,	,	,
cord-012045-1cqqj84n	249	9	OTUD5	OTUD5	NNP
cord-012045-1cqqj84n	249	10	/	/	SYM
cord-012045-1cqqj84n	249	11	DUBA	DUBA	NNP
cord-012045-1cqqj84n	249	12	,	,	,
cord-012045-1cqqj84n	249	13	OTUD6A	OTUD6A	NNP
cord-012045-1cqqj84n	249	14	,	,	,
cord-012045-1cqqj84n	250	1	OTUD6B	OTUD6B	NNP
cord-012045-1cqqj84n	250	2	,	,	,
cord-012045-1cqqj84n	250	3	ALG13	ALG13	NNP
cord-012045-1cqqj84n	250	4	,	,	,
cord-012045-1cqqj84n	250	5	and	and	CC
cord-012045-1cqqj84n	250	6	HIN1L	hin1l	CD
cord-012045-1cqqj84n	250	7	)	)	-RRB-
cord-012045-1cqqj84n	250	8	,	,	,
cord-012045-1cqqj84n	250	9	and	and	CC
cord-012045-1cqqj84n	250	10	A20s	a20s	NN
cord-012045-1cqqj84n	251	1	(	(	-LRB-
cord-012045-1cqqj84n	251	2	A20	A20	NNP
cord-012045-1cqqj84n	251	3	,	,	,
cord-012045-1cqqj84n	251	4	Cezanne	Cezanne	NNP
cord-012045-1cqqj84n	251	5	,	,	,
cord-012045-1cqqj84n	251	6	Cezanne2	Cezanne2	NNP
cord-012045-1cqqj84n	251	7	,	,	,
cord-012045-1cqqj84n	251	8	TRABID	TRABID	NNP
cord-012045-1cqqj84n	251	9	,	,	,
cord-012045-1cqqj84n	251	10	and	and	CC
cord-012045-1cqqj84n	251	11	VCPIP	VCPIP	NNP
cord-012045-1cqqj84n	251	12	)	)	-RRB-
cord-012045-1cqqj84n	251	13	[	[	-LRB-
cord-012045-1cqqj84n	251	14	126	126	CD
cord-012045-1cqqj84n	251	15	]	]	-RRB-
cord-012045-1cqqj84n	251	16	.	.	.
cord-012045-1cqqj84n	252	1	The	the	DT
cord-012045-1cqqj84n	252	2	majority	majority	NN
cord-012045-1cqqj84n	252	3	of	of	IN
cord-012045-1cqqj84n	252	4	OTU	OTU	NNP
cord-012045-1cqqj84n	252	5	members	member	NNS
cord-012045-1cqqj84n	252	6	are	be	VBP
cord-012045-1cqqj84n	252	7	reported	report	VBN
cord-012045-1cqqj84n	252	8	to	to	TO
cord-012045-1cqqj84n	252	9	regulate	regulate	VB
cord-012045-1cqqj84n	252	10	pathogen	pathogen	NN
cord-012045-1cqqj84n	252	11	-	-	HYPH
cord-012045-1cqqj84n	252	12	induced	induce	VBN
cord-012045-1cqqj84n	252	13	cell	cell	NN
cord-012045-1cqqj84n	252	14	signaling	signal	VBG
cord-012045-1cqqj84n	252	15	cascades	cascade	NNS
cord-012045-1cqqj84n	252	16	.	.	.
cord-012045-1cqqj84n	253	1	In	in	IN
cord-012045-1cqqj84n	253	2	innate	innate	JJ
cord-012045-1cqqj84n	253	3	and	and	CC
cord-012045-1cqqj84n	253	4	adaptive	adaptive	JJ
cord-012045-1cqqj84n	253	5	immunity	immunity	NN
cord-012045-1cqqj84n	253	6	,	,	,
cord-012045-1cqqj84n	253	7	OTULIN	OTULIN	NNP
cord-012045-1cqqj84n	253	8	is	be	VBZ
cord-012045-1cqqj84n	253	9	an	an	DT
cord-012045-1cqqj84n	253	10	essential	essential	JJ
cord-012045-1cqqj84n	253	11	negative	negative	JJ
cord-012045-1cqqj84n	253	12	regulator	regulator	NN
cord-012045-1cqqj84n	253	13	of	of	IN
cord-012045-1cqqj84n	253	14	LUBAC	LUBAC	NNP
cord-012045-1cqqj84n	253	15	,	,	,
cord-012045-1cqqj84n	254	1	which	which	WDT
cord-012045-1cqqj84n	254	2	hydrolyzes	hydrolyze	VBZ
cord-012045-1cqqj84n	254	3	LUBAC	LUBAC	NNP
cord-012045-1cqqj84n	254	4	induced	induce	VBN
cord-012045-1cqqj84n	254	5	Met-1	Met-1	NNP
cord-012045-1cqqj84n	254	6	lineal	lineal	JJ
cord-012045-1cqqj84n	254	7	ubiquitination	ubiquitination	NN
cord-012045-1cqqj84n	254	8	to	to	TO
cord-012045-1cqqj84n	254	9	prevent	prevent	VB
cord-012045-1cqqj84n	254	10	NF	nf	NN
cord-012045-1cqqj84n	254	11	-	-	HYPH
cord-012045-1cqqj84n	254	12	κB	κB	NNP
cord-012045-1cqqj84n	254	13	-	-	:
cord-012045-1cqqj84n	254	14	or	or	CC
cord-012045-1cqqj84n	254	15	TNF	TNF	NNP
cord-012045-1cqqj84n	254	16	-	-	HYPH
cord-012045-1cqqj84n	254	17	induced	induce	VBN
cord-012045-1cqqj84n	254	18	inflammation	inflammation	NN
cord-012045-1cqqj84n	254	19	augmentation	augmentation	NN
cord-012045-1cqqj84n	254	20	[	[	-LRB-
cord-012045-1cqqj84n	254	21	71	71	CD
cord-012045-1cqqj84n	254	22	]	]	-RRB-
cord-012045-1cqqj84n	255	1	[	[	-LRB-
cord-012045-1cqqj84n	255	2	72	72	CD
cord-012045-1cqqj84n	255	3	]	]	-RRB-
cord-012045-1cqqj84n	256	1	[	[	-LRB-
cord-012045-1cqqj84n	256	2	73	73	CD
cord-012045-1cqqj84n	256	3	]	]	-RRB-
cord-012045-1cqqj84n	256	4	127	127	CD
cord-012045-1cqqj84n	256	5	]	]	-RRB-
cord-012045-1cqqj84n	256	6	.	.	.
cord-012045-1cqqj84n	257	1	OTULIN	OTULIN	NNP
cord-012045-1cqqj84n	257	2	can	can	MD
cord-012045-1cqqj84n	257	3	also	also	RB
cord-012045-1cqqj84n	257	4	control	control	VB
cord-012045-1cqqj84n	257	5	antiviral	antiviral	JJ
cord-012045-1cqqj84n	257	6	signaling	signal	VBG
cord-012045-1cqqj84n	257	7	by	by	IN
cord-012045-1cqqj84n	257	8	regulating	regulate	VBG
cord-012045-1cqqj84n	257	9	the	the	DT
cord-012045-1cqqj84n	257	10	lineal	lineal	JJ
cord-012045-1cqqj84n	257	11	ubiquitination	ubiquitination	NN
cord-012045-1cqqj84n	257	12	chain	chain	NN
cord-012045-1cqqj84n	257	13	of	of	IN
cord-012045-1cqqj84n	257	14	STAT1	stat1	NN
cord-012045-1cqqj84n	257	15	[	[	-LRB-
cord-012045-1cqqj84n	257	16	74	74	CD
cord-012045-1cqqj84n	257	17	]	]	-RRB-
cord-012045-1cqqj84n	257	18	.	.	.
cord-012045-1cqqj84n	258	1	For	for	IN
cord-012045-1cqqj84n	258	2	the	the	DT
cord-012045-1cqqj84n	258	3	negative	negative	JJ
cord-012045-1cqqj84n	258	4	role	role	NN
cord-012045-1cqqj84n	258	5	of	of	IN
cord-012045-1cqqj84n	258	6	OTULIN	OTULIN	NNP
cord-012045-1cqqj84n	258	7	in	in	IN
cord-012045-1cqqj84n	258	8	immune	immune	JJ
cord-012045-1cqqj84n	258	9	responses	response	NNS
cord-012045-1cqqj84n	258	10	,	,	,
cord-012045-1cqqj84n	258	11	OTULIN	OTULIN	NNP
cord-012045-1cqqj84n	258	12	deficiency	deficiency	NN
cord-012045-1cqqj84n	258	13	might	may	MD
cord-012045-1cqqj84n	258	14	cause	cause	VB
cord-012045-1cqqj84n	258	15	auto	auto	NN
cord-012045-1cqqj84n	258	16	-	-	HYPH
cord-012045-1cqqj84n	258	17	inflammatory	inflammatory	JJ
cord-012045-1cqqj84n	258	18	syndrome	syndrome	NN
cord-012045-1cqqj84n	258	19	[	[	-LRB-
cord-012045-1cqqj84n	258	20	128	128	CD
cord-012045-1cqqj84n	258	21	]	]	-RRB-
cord-012045-1cqqj84n	258	22	.	.	.
cord-012045-1cqqj84n	259	1	OTUB1	OTUB1	NNP
cord-012045-1cqqj84n	259	2	and	and	CC
cord-012045-1cqqj84n	259	3	OTUB2	OTUB2	NNP
cord-012045-1cqqj84n	259	4	regulate	regulate	VBP
cord-012045-1cqqj84n	260	1	virus	virus	NN
cord-012045-1cqqj84n	260	2	-	-	:
cord-012045-1cqqj84n	260	3	triggered	trigger	VBN
cord-012045-1cqqj84n	260	4	IFN	IFN	NNP
cord-012045-1cqqj84n	260	5	inflammation	inflammation	NN
cord-012045-1cqqj84n	260	6	by	by	IN
cord-012045-1cqqj84n	260	7	deubiquitinating	deubiquitinate	VBG
cord-012045-1cqqj84n	260	8	TRAF3	traf3	XX
cord-012045-1cqqj84n	261	1	and	and	CC
cord-012045-1cqqj84n	261	2	TRAF6	TRAF6	NNP
cord-012045-1cqqj84n	261	3	[	[	-LRB-
cord-012045-1cqqj84n	261	4	75	75	CD
cord-012045-1cqqj84n	261	5	]	]	-RRB-
cord-012045-1cqqj84n	261	6	.	.	.
cord-012045-1cqqj84n	262	1	OTUB1	OTUB1	NNP
cord-012045-1cqqj84n	262	2	suppresses	suppress	VBZ
cord-012045-1cqqj84n	262	3	the	the	DT
cord-012045-1cqqj84n	262	4	E3	E3	NNP
cord-012045-1cqqj84n	262	5	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	262	6	-	-	HYPH
cord-012045-1cqqj84n	262	7	ligase	ligase	NN
cord-012045-1cqqj84n	262	8	by	by	IN
cord-012045-1cqqj84n	262	9	co	co	JJ
cord-012045-1cqqj84n	262	10	-	-	JJ
cord-012045-1cqqj84n	262	11	opting	opt	VBG
cord-012045-1cqqj84n	262	12	K48	K48	NNP
cord-012045-1cqqj84n	262	13	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	262	14	recognition	recognition	NN
cord-012045-1cqqj84n	262	15	to	to	TO
cord-012045-1cqqj84n	262	16	regulate	regulate	VB
cord-012045-1cqqj84n	262	17	DNA	dna	NN
cord-012045-1cqqj84n	262	18	damage	damage	NN
cord-012045-1cqqj84n	262	19	[	[	-LRB-
cord-012045-1cqqj84n	262	20	76	76	CD
cord-012045-1cqqj84n	262	21	,	,	,
cord-012045-1cqqj84n	262	22	[	[	-LRB-
cord-012045-1cqqj84n	262	23	129	129	CD
cord-012045-1cqqj84n	262	24	]	]	-RRB-
cord-012045-1cqqj84n	262	25	[	[	-LRB-
cord-012045-1cqqj84n	262	26	130	130	CD
cord-012045-1cqqj84n	262	27	]	]	-RRB-
cord-012045-1cqqj84n	262	28	[	[	-LRB-
cord-012045-1cqqj84n	262	29	131	131	CD
cord-012045-1cqqj84n	262	30	]	]	-RRB-
cord-012045-1cqqj84n	262	31	[	[	-LRB-
cord-012045-1cqqj84n	262	32	132	132	CD
cord-012045-1cqqj84n	262	33	]	]	-RRB-
cord-012045-1cqqj84n	262	34	.	.	.
cord-012045-1cqqj84n	263	1	Recent	recent	JJ
cord-012045-1cqqj84n	263	2	studies	study	NNS
cord-012045-1cqqj84n	263	3	also	also	RB
cord-012045-1cqqj84n	263	4	show	show	VBP
cord-012045-1cqqj84n	263	5	that	that	IN
cord-012045-1cqqj84n	263	6	OTUB1	otub1	NN
cord-012045-1cqqj84n	263	7	augments	augment	VBZ
cord-012045-1cqqj84n	263	8	NF	nf	NN
cord-012045-1cqqj84n	263	9	-	-	HYPH
cord-012045-1cqqj84n	263	10	κB	κB	NNP
cord-012045-1cqqj84n	263	11	-	-	HYPH
cord-012045-1cqqj84n	263	12	dependent	dependent	JJ
cord-012045-1cqqj84n	263	13	immune	immune	JJ
cord-012045-1cqqj84n	263	14	responses	response	NNS
cord-012045-1cqqj84n	263	15	in	in	IN
cord-012045-1cqqj84n	263	16	dendritic	dendritic	JJ
cord-012045-1cqqj84n	263	17	cells	cell	NNS
cord-012045-1cqqj84n	263	18	in	in	IN
cord-012045-1cqqj84n	263	19	infection	infection	NN
cord-012045-1cqqj84n	263	20	and	and	CC
cord-012045-1cqqj84n	263	21	inflammation	inflammation	NN
cord-012045-1cqqj84n	263	22	by	by	IN
cord-012045-1cqqj84n	263	23	stabilizing	stabilize	VBG
cord-012045-1cqqj84n	263	24	UBC13	UBC13	NNP
cord-012045-1cqqj84n	263	25	[	[	-LRB-
cord-012045-1cqqj84n	263	26	76	76	CD
cord-012045-1cqqj84n	263	27	]	]	-RRB-
cord-012045-1cqqj84n	263	28	.	.	.
cord-012045-1cqqj84n	264	1	OTUB1	OTUB1	NNP
cord-012045-1cqqj84n	264	2	recruits	recruit	NNS
cord-012045-1cqqj84n	264	3	phosphorylated	phosphorylate	VBD
cord-012045-1cqqj84n	264	4	SMAD2/3	SMAD2/3	NNP
cord-012045-1cqqj84n	264	5	and	and	CC
cord-012045-1cqqj84n	264	6	inhibits	inhibit	VBZ
cord-012045-1cqqj84n	264	7	its	-PRON-	PRP$
cord-012045-1cqqj84n	264	8	ubiquitination	ubiquitination	NN
cord-012045-1cqqj84n	264	9	by	by	IN
cord-012045-1cqqj84n	264	10	binding	bind	VBG
cord-012045-1cqqj84n	264	11	with	with	IN
cord-012045-1cqqj84n	264	12	E2	E2	NNP
cord-012045-1cqqj84n	264	13	Ub	Ub	NNP
cord-012045-1cqqj84n	264	14	-	-	HYPH
cord-012045-1cqqj84n	264	15	conjugating	conjugate	VBG
cord-012045-1cqqj84n	264	16	enzyme	enzyme	NN
cord-012045-1cqqj84n	264	17	to	to	TO
cord-012045-1cqqj84n	264	18	enhance	enhance	VB
cord-012045-1cqqj84n	264	19	TGF	TGF	NNP
cord-012045-1cqqj84n	264	20	-	-	HYPH
cord-012045-1cqqj84n	264	21	β	β	NN
cord-012045-1cqqj84n	264	22	signaling	signal	VBG
cord-012045-1cqqj84n	264	23	[	[	-LRB-
cord-012045-1cqqj84n	264	24	80	80	CD
cord-012045-1cqqj84n	264	25	]	]	-RRB-
cord-012045-1cqqj84n	264	26	.	.	.
cord-012045-1cqqj84n	265	1	OTUB1	OTUB1	NNP
cord-012045-1cqqj84n	265	2	regulates	regulate	VBZ
cord-012045-1cqqj84n	265	3	the	the	DT
cord-012045-1cqqj84n	265	4	maturation	maturation	NN
cord-012045-1cqqj84n	265	5	and	and	CC
cord-012045-1cqqj84n	265	6	activation	activation	NN
cord-012045-1cqqj84n	265	7	of	of	IN
cord-012045-1cqqj84n	265	8	NK	NK	NNP
cord-012045-1cqqj84n	265	9	and	and	CC
cord-012045-1cqqj84n	265	10	CD8+T	cd8+t	NN
cord-012045-1cqqj84n	265	11	cells	cell	NNS
cord-012045-1cqqj84n	265	12	via	via	IN
cord-012045-1cqqj84n	265	13	inhibiting	inhibit	VBG
cord-012045-1cqqj84n	265	14	AKT	akt	NN
cord-012045-1cqqj84n	265	15	ubiquitination	ubiquitination	NN
cord-012045-1cqqj84n	265	16	[	[	-LRB-
cord-012045-1cqqj84n	265	17	77	77	CD
cord-012045-1cqqj84n	265	18	]	]	-RRB-
cord-012045-1cqqj84n	265	19	.	.	.
cord-012045-1cqqj84n	266	1	Furthermore	furthermore	RB
cord-012045-1cqqj84n	266	2	,	,	,
cord-012045-1cqqj84n	266	3	virus	virus	NN
cord-012045-1cqqj84n	266	4	-	-	HYPH
cord-012045-1cqqj84n	266	5	induced	induce	VBN
cord-012045-1cqqj84n	266	6	OTUB1	otub1	NN
cord-012045-1cqqj84n	266	7	degradation	degradation	NN
cord-012045-1cqqj84n	266	8	blocks	block	VBZ
cord-012045-1cqqj84n	266	9	the	the	DT
cord-012045-1cqqj84n	266	10	RIG	rig	NN
cord-012045-1cqqj84n	266	11	-	-	HYPH
cord-012045-1cqqj84n	266	12	I	i	NN
cord-012045-1cqqj84n	266	13	-	-	HYPH
cord-012045-1cqqj84n	266	14	dependent	dependent	JJ
cord-012045-1cqqj84n	266	15	immune	immune	NN
cord-012045-1cqqj84n	266	16	signaling	signal	VBG
cord-012045-1cqqj84n	266	17	cascade	cascade	NN
cord-012045-1cqqj84n	266	18	and	and	CC
cord-012045-1cqqj84n	266	19	antiviral	antiviral	JJ
cord-012045-1cqqj84n	266	20	response	response	NN
cord-012045-1cqqj84n	266	21	[	[	-LRB-
cord-012045-1cqqj84n	266	22	79	79	CD
cord-012045-1cqqj84n	266	23	]	]	-RRB-
cord-012045-1cqqj84n	266	24	.	.	.
cord-012045-1cqqj84n	267	1	Several	several	JJ
cord-012045-1cqqj84n	267	2	studies	study	NNS
cord-012045-1cqqj84n	267	3	showed	show	VBD
cord-012045-1cqqj84n	267	4	that	that	IN
cord-012045-1cqqj84n	267	5	OTUD1	otud1	PRP
cord-012045-1cqqj84n	267	6	plays	play	VBZ
cord-012045-1cqqj84n	267	7	an	an	DT
cord-012045-1cqqj84n	267	8	important	important	JJ
cord-012045-1cqqj84n	267	9	role	role	NN
cord-012045-1cqqj84n	267	10	in	in	IN
cord-012045-1cqqj84n	267	11	inflammation	inflammation	NN
cord-012045-1cqqj84n	267	12	regulation	regulation	NN
cord-012045-1cqqj84n	267	13	[	[	-LRB-
cord-012045-1cqqj84n	267	14	81	81	CD
cord-012045-1cqqj84n	267	15	,	,	,
cord-012045-1cqqj84n	267	16	82	82	CD
cord-012045-1cqqj84n	267	17	]	]	-RRB-
cord-012045-1cqqj84n	267	18	.	.	.
cord-012045-1cqqj84n	268	1	RNA	RNA	NNP
cord-012045-1cqqj84n	268	2	viruses	virus	NNS
cord-012045-1cqqj84n	269	1	induceOTUD1	induceotud1	PRP
cord-012045-1cqqj84n	269	2	to	to	TO
cord-012045-1cqqj84n	269	3	promote	promote	VB
cord-012045-1cqqj84n	269	4	the	the	DT
cord-012045-1cqqj84n	269	5	degradation	degradation	NN
cord-012045-1cqqj84n	269	6	of	of	IN
cord-012045-1cqqj84n	269	7	the	the	DT
cord-012045-1cqqj84n	269	8	MAVS	MAVS	NNPS
cord-012045-1cqqj84n	269	9	/	/	SYM
cord-012045-1cqqj84n	269	10	TRAF3	TRAF3	NNP
cord-012045-1cqqj84n	269	11	/	/	SYM
cord-012045-1cqqj84n	269	12	TRAF6	TRAF6	NNP
cord-012045-1cqqj84n	269	13	signalosome	signalosome	NN
cord-012045-1cqqj84n	269	14	to	to	TO
cord-012045-1cqqj84n	269	15	inhibit	inhibit	VB
cord-012045-1cqqj84n	269	16	innate	innate	JJ
cord-012045-1cqqj84n	269	17	immunity	immunity	NN
cord-012045-1cqqj84n	269	18	[	[	-LRB-
cord-012045-1cqqj84n	269	19	81	81	CD
cord-012045-1cqqj84n	269	20	]	]	-RRB-
cord-012045-1cqqj84n	269	21	.	.	.
cord-012045-1cqqj84n	270	1	Furthermore	furthermore	RB
cord-012045-1cqqj84n	270	2	,	,	,
cord-012045-1cqqj84n	270	3	OTUD1	OTUD1	NNP
cord-012045-1cqqj84n	270	4	inhibits	inhibit	VBZ
cord-012045-1cqqj84n	270	5	type	type	NN
cord-012045-1cqqj84n	270	6	1	1	CD
cord-012045-1cqqj84n	270	7	IFN	IFN	NNP
cord-012045-1cqqj84n	270	8	induction	induction	NN
cord-012045-1cqqj84n	270	9	after	after	IN
cord-012045-1cqqj84n	270	10	virus	virus	NN
cord-012045-1cqqj84n	270	11	infection	infection	NN
cord-012045-1cqqj84n	270	12	through	through	IN
cord-012045-1cqqj84n	270	13	cleaving	cleave	VBG
cord-012045-1cqqj84n	270	14	noncanonical	noncanonical	JJ
cord-012045-1cqqj84n	270	15	K6-linked	k6-linke	VBN
cord-012045-1cqqj84n	270	16	ubiquitination	ubiquitination	NN
cord-012045-1cqqj84n	270	17	of	of	IN
cord-012045-1cqqj84n	270	18	IRF3	IRF3	NNP
cord-012045-1cqqj84n	270	19	[	[	-LRB-
cord-012045-1cqqj84n	270	20	83	83	CD
cord-012045-1cqqj84n	270	21	]	]	-RRB-
cord-012045-1cqqj84n	270	22	.	.	.
cord-012045-1cqqj84n	271	1	OTUD1	otud1	NN
cord-012045-1cqqj84n	272	1	knockout	knockout	NNP
cord-012045-1cqqj84n	272	2	mice	mouse	NNS
cord-012045-1cqqj84n	272	3	show	show	VBP
cord-012045-1cqqj84n	272	4	more	more	JJR
cord-012045-1cqqj84n	272	5	resistance	resistance	NN
cord-012045-1cqqj84n	272	6	to	to	IN
cord-012045-1cqqj84n	272	7	virus	virus	NN
cord-012045-1cqqj84n	272	8	infection	infection	NN
cord-012045-1cqqj84n	272	9	and	and	CC
cord-012045-1cqqj84n	272	10	LPS	LPS	NNP
cord-012045-1cqqj84n	272	11	stimulation	stimulation	NN
cord-012045-1cqqj84n	272	12	[	[	-LRB-
cord-012045-1cqqj84n	272	13	81	81	CD
cord-012045-1cqqj84n	272	14	,	,	,
cord-012045-1cqqj84n	272	15	83	83	CD
cord-012045-1cqqj84n	272	16	]	]	-RRB-
cord-012045-1cqqj84n	272	17	.	.	.
cord-012045-1cqqj84n	273	1	OTUD4	OTUD4	NNP
cord-012045-1cqqj84n	273	2	is	be	VBZ
cord-012045-1cqqj84n	273	3	a	a	DT
cord-012045-1cqqj84n	273	4	K48-specific	K48-specific	NNP
cord-012045-1cqqj84n	273	5	deubiquitinating	deubiquitinating	NN
cord-012045-1cqqj84n	273	6	enzyme	enzyme	NN
cord-012045-1cqqj84n	273	7	that	that	WDT
cord-012045-1cqqj84n	273	8	is	be	VBZ
cord-012045-1cqqj84n	273	9	previously	previously	RB
cord-012045-1cqqj84n	273	10	been	be	VBN
cord-012045-1cqqj84n	273	11	reported	report	VBN
cord-012045-1cqqj84n	273	12	to	to	TO
cord-012045-1cqqj84n	273	13	maintain	maintain	VB
cord-012045-1cqqj84n	273	14	the	the	DT
cord-012045-1cqqj84n	273	15	stability	stability	NN
cord-012045-1cqqj84n	273	16	of	of	IN
cord-012045-1cqqj84n	273	17	the	the	DT
cord-012045-1cqqj84n	273	18	alkylation	alkylation	NN
cord-012045-1cqqj84n	273	19	repair	repair	NN
cord-012045-1cqqj84n	273	20	enzyme	enzyme	NN
cord-012045-1cqqj84n	273	21	ALKBH3	alkbh3	NN
cord-012045-1cqqj84n	273	22	for	for	IN
cord-012045-1cqqj84n	273	23	promoting	promote	VBG
cord-012045-1cqqj84n	273	24	DNA	dna	NN
cord-012045-1cqqj84n	273	25	damage	damage	NN
cord-012045-1cqqj84n	273	26	repair	repair	NN
cord-012045-1cqqj84n	273	27	[	[	-LRB-
cord-012045-1cqqj84n	273	28	86	86	CD
cord-012045-1cqqj84n	273	29	]	]	-RRB-
cord-012045-1cqqj84n	273	30	.	.	.
cord-012045-1cqqj84n	274	1	However	however	RB
cord-012045-1cqqj84n	274	2	,	,	,
cord-012045-1cqqj84n	274	3	OTUD4	OTUD4	NNP
cord-012045-1cqqj84n	274	4	also	also	RB
cord-012045-1cqqj84n	274	5	preserves	preserve	VBZ
cord-012045-1cqqj84n	274	6	K63-linked	K63-linked	NNP
cord-012045-1cqqj84n	274	7	deubiquitinating	deubiquitinating	NN
cord-012045-1cqqj84n	274	8	activity	activity	NN
cord-012045-1cqqj84n	274	9	,	,	,
cord-012045-1cqqj84n	274	10	specifically	specifically	RB
cord-012045-1cqqj84n	274	11	targetingMyD88	targetingMyD88	,
cord-012045-1cqqj84n	274	12	to	to	TO
cord-012045-1cqqj84n	274	13	inhibit	inhibit	VB
cord-012045-1cqqj84n	275	1	NF	NF	NNP
cord-012045-1cqqj84n	275	2	-	-	HYPH
cord-012045-1cqqj84n	275	3	κB	κB	NNP
cord-012045-1cqqj84n	275	4	signaling	signal	VBG
cord-012045-1cqqj84n	275	5	[	[	-LRB-
cord-012045-1cqqj84n	275	6	84	84	CD
cord-012045-1cqqj84n	275	7	]	]	-RRB-
cord-012045-1cqqj84n	275	8	.	.	.
cord-012045-1cqqj84n	276	1	A	a	DT
cord-012045-1cqqj84n	276	2	recent	recent	JJ
cord-012045-1cqqj84n	276	3	study	study	NN
cord-012045-1cqqj84n	276	4	shows	show	VBZ
cord-012045-1cqqj84n	276	5	the	the	DT
cord-012045-1cqqj84n	276	6	role	role	NN
cord-012045-1cqqj84n	276	7	of	of	IN
cord-012045-1cqqj84n	276	8	OTUD4	OTUD4	NNP
cord-012045-1cqqj84n	276	9	in	in	IN
cord-012045-1cqqj84n	276	10	innate	innate	JJ
cord-012045-1cqqj84n	276	11	antiviral	antiviral	JJ
cord-012045-1cqqj84n	276	12	immunity	immunity	NN
cord-012045-1cqqj84n	276	13	.	.	.
cord-012045-1cqqj84n	277	1	OTUD4	OTUD4	NNP
cord-012045-1cqqj84n	277	2	is	be	VBZ
cord-012045-1cqqj84n	277	3	induced	induce	VBN
cord-012045-1cqqj84n	277	4	by	by	IN
cord-012045-1cqqj84n	277	5	virus	virus	NN
cord-012045-1cqqj84n	277	6	infection	infection	NN
cord-012045-1cqqj84n	277	7	and	and	CC
cord-012045-1cqqj84n	277	8	targets	target	NNS
cord-012045-1cqqj84n	277	9	MAVS	mavs	RB
cord-012045-1cqqj84n	277	10	ubiquitination	ubiquitination	NN
cord-012045-1cqqj84n	277	11	,	,	,
cord-012045-1cqqj84n	277	12	triggeringIRF3	triggeringirf3	NN
cord-012045-1cqqj84n	277	13	and	and	CC
cord-012045-1cqqj84n	278	1	NF	NF	NNP
cord-012045-1cqqj84n	278	2	-	-	HYPH
cord-012045-1cqqj84n	278	3	κB	κB	NNP
cord-012045-1cqqj84n	278	4	signaling	signal	VBG
cord-012045-1cqqj84n	278	5	to	to	TO
cord-012045-1cqqj84n	278	6	sustain	sustain	VB
cord-012045-1cqqj84n	278	7	antiviral	antiviral	JJ
cord-012045-1cqqj84n	278	8	responses	response	NNS
cord-012045-1cqqj84n	278	9	[	[	-LRB-
cord-012045-1cqqj84n	278	10	85	85	CD
cord-012045-1cqqj84n	278	11	]	]	-RRB-
cord-012045-1cqqj84n	278	12	.Like	.Like	.
cord-012045-1cqqj84n	279	1	most	most	JJS
cord-012045-1cqqj84n	279	2	of	of	IN
cord-012045-1cqqj84n	279	3	the	the	DT
cord-012045-1cqqj84n	279	4	DUBs	dub	NNS
cord-012045-1cqqj84n	279	5	,	,	,
cord-012045-1cqqj84n	279	6	the	the	DT
cord-012045-1cqqj84n	279	7	family	family	NN
cord-012045-1cqqj84n	279	8	member	member	NN
cord-012045-1cqqj84n	279	9	A20	A20	NNP
cord-012045-1cqqj84n	279	10	shows	show	VBZ
cord-012045-1cqqj84n	279	11	the	the	DT
cord-012045-1cqqj84n	279	12	negative	negative	JJ
cord-012045-1cqqj84n	279	13	effect	effect	NN
cord-012045-1cqqj84n	279	14	on	on	IN
cord-012045-1cqqj84n	279	15	the	the	DT
cord-012045-1cqqj84n	279	16	activation	activation	NN
cord-012045-1cqqj84n	279	17	of	of	IN
cord-012045-1cqqj84n	279	18	NF	nf	NN
cord-012045-1cqqj84n	279	19	-	-	HYPH
cord-012045-1cqqj84n	279	20	κB	κB	NNP
cord-012045-1cqqj84n	279	21	signaling	signal	VBG
cord-012045-1cqqj84n	279	22	[	[	-LRB-
cord-012045-1cqqj84n	279	23	87	87	CD
cord-012045-1cqqj84n	279	24	,	,	,
cord-012045-1cqqj84n	279	25	88	88	CD
cord-012045-1cqqj84n	280	1	,	,	,
cord-012045-1cqqj84n	280	2	133	133	CD
cord-012045-1cqqj84n	280	3	]	]	-RRB-
cord-012045-1cqqj84n	280	4	.Myeloid	.myeloid	CD
cord-012045-1cqqj84n	280	5	-	-	:
cord-012045-1cqqj84n	280	6	A20-deficiency	A20-deficiency	NNP
cord-012045-1cqqj84n	280	7	shows	show	VBZ
cord-012045-1cqqj84n	280	8	a	a	DT
cord-012045-1cqqj84n	280	9	higher	high	JJR
cord-012045-1cqqj84n	280	10	inflammatory	inflammatory	JJ
cord-012045-1cqqj84n	280	11	reaction	reaction	NN
cord-012045-1cqqj84n	280	12	and	and	CC
cord-012045-1cqqj84n	280	13	sustained	sustain	VBD
cord-012045-1cqqj84n	280	14	NF	nf	NN
cord-012045-1cqqj84n	280	15	-	-	HYPH
cord-012045-1cqqj84n	280	16	κB	κb	CD
cord-012045-1cqqj84n	280	17	activation	activation	NN
cord-012045-1cqqj84n	280	18	[	[	-LRB-
cord-012045-1cqqj84n	280	19	133	133	CD
cord-012045-1cqqj84n	280	20	]	]	-RRB-
cord-012045-1cqqj84n	280	21	.	.	.
cord-012045-1cqqj84n	281	1	A20	A20	NNP
cord-012045-1cqqj84n	281	2	terminates	terminate	VBZ
cord-012045-1cqqj84n	281	3	TLR	TLR	NNP
cord-012045-1cqqj84n	281	4	signals	signal	NNS
cord-012045-1cqqj84n	281	5	by	by	IN
cord-012045-1cqqj84n	281	6	targeting	target	VBG
cord-012045-1cqqj84n	281	7	TRAF6	TRAF6	NNP
cord-012045-1cqqj84n	281	8	deubiquitination	deubiquitination	NNP
cord-012045-1cqqj84n	281	9	[	[	-LRB-
cord-012045-1cqqj84n	281	10	87	87	CD
cord-012045-1cqqj84n	281	11	]	]	-RRB-
cord-012045-1cqqj84n	281	12	.	.	.
cord-012045-1cqqj84n	282	1	Similar	similar	JJ
cord-012045-1cqqj84n	282	2	to	to	IN
cord-012045-1cqqj84n	282	3	OTUB1	otub1	VB
cord-012045-1cqqj84n	282	4	,	,	,
cord-012045-1cqqj84n	282	5	A20	A20	NNP
cord-012045-1cqqj84n	282	6	suppresses	suppress	VBZ
cord-012045-1cqqj84n	282	7	NF	nf	NN
cord-012045-1cqqj84n	282	8	-	-	HYPH
cord-012045-1cqqj84n	282	9	κB	κB	NNP
cord-012045-1cqqj84n	282	10	signaling	signaling	NN
cord-012045-1cqqj84n	282	11	by	by	IN
cord-012045-1cqqj84n	282	12	conjugating	conjugate	VBG
cord-012045-1cqqj84n	282	13	to	to	IN
cord-012045-1cqqj84n	282	14	E3	E3	NNP
cord-012045-1cqqj84n	282	15	Ub	Ub	NNP
cord-012045-1cqqj84n	282	16	-	-	HYPH
cord-012045-1cqqj84n	282	17	ligase	ligase	NN
cord-012045-1cqqj84n	282	18	[	[	-LRB-
cord-012045-1cqqj84n	282	19	88	88	CD
cord-012045-1cqqj84n	282	20	]	]	-RRB-
cord-012045-1cqqj84n	282	21	.	.	.
cord-012045-1cqqj84n	283	1	Histone	histone	JJ
cord-012045-1cqqj84n	283	2	methyltransferase	methyltransferase	NN
cord-012045-1cqqj84n	283	3	-	-	HYPH
cord-012045-1cqqj84n	283	4	enhanced	enhance	VBN
cord-012045-1cqqj84n	283	5	A20	A20	NNP
cord-012045-1cqqj84n	283	6	can	can	MD
cord-012045-1cqqj84n	283	7	also	also	RB
cord-012045-1cqqj84n	283	8	suppress	suppress	VB
cord-012045-1cqqj84n	283	9	the	the	DT
cord-012045-1cqqj84n	283	10	inflammatory	inflammatory	JJ
cord-012045-1cqqj84n	283	11	response	response	NN
cord-012045-1cqqj84n	283	12	by	by	IN
cord-012045-1cqqj84n	283	13	modulation	modulation	NN
cord-012045-1cqqj84n	283	14	of	of	IN
cord-012045-1cqqj84n	283	15	NEMO	NEMO	NNP
cord-012045-1cqqj84n	283	16	and	and	CC
cord-012045-1cqqj84n	283	17	deubiquitination	deubiquitination	NN
cord-012045-1cqqj84n	283	18	of	of	IN
cord-012045-1cqqj84n	283	19	TRAF6	TRAF6	NNP
cord-012045-1cqqj84n	283	20	[	[	-LRB-
cord-012045-1cqqj84n	283	21	134	134	CD
cord-012045-1cqqj84n	283	22	]	]	-RRB-
cord-012045-1cqqj84n	283	23	.	.	.
cord-012045-1cqqj84n	284	1	Due	due	IN
cord-012045-1cqqj84n	284	2	to	to	IN
cord-012045-1cqqj84n	284	3	its	-PRON-	PRP$
cord-012045-1cqqj84n	284	4	role	role	NN
cord-012045-1cqqj84n	284	5	in	in	IN
cord-012045-1cqqj84n	284	6	inflammation	inflammation	NN
cord-012045-1cqqj84n	284	7	inhibition	inhibition	NN
cord-012045-1cqqj84n	284	8	,	,	,
cord-012045-1cqqj84n	284	9	A20	A20	NNP
cord-012045-1cqqj84n	284	10	induced	induce	VBN
cord-012045-1cqqj84n	284	11	by	by	IN
cord-012045-1cqqj84n	284	12	TNFα	TNFα	NNP
cord-012045-1cqqj84n	284	13	participates	participate	VBZ
cord-012045-1cqqj84n	284	14	in	in	IN
cord-012045-1cqqj84n	284	15	age	age	NN
cord-012045-1cqqj84n	284	16	-	-	HYPH
cord-012045-1cqqj84n	284	17	related	relate	VBN
cord-012045-1cqqj84n	284	18	macrophage	macrophage	NN
cord-012045-1cqqj84n	284	19	dysfunction	dysfunction	NN
cord-012045-1cqqj84n	284	20	in	in	IN
cord-012045-1cqqj84n	284	21	the	the	DT
cord-012045-1cqqj84n	284	22	lung	lung	NN
cord-012045-1cqqj84n	284	23	[	[	-LRB-
cord-012045-1cqqj84n	284	24	135	135	CD
cord-012045-1cqqj84n	284	25	]	]	-RRB-
cord-012045-1cqqj84n	284	26	.	.	.
cord-012045-1cqqj84n	285	1	OTUDs	otud	NNS
cord-012045-1cqqj84n	285	2	are	be	VBP
cord-012045-1cqqj84n	285	3	newly	newly	RB
cord-012045-1cqqj84n	285	4	discovered	discover	VBN
cord-012045-1cqqj84n	285	5	in	in	IN
cord-012045-1cqqj84n	285	6	antiviral	antiviral	JJ
cord-012045-1cqqj84n	285	7	immune	immune	JJ
cord-012045-1cqqj84n	285	8	responses	response	NNS
cord-012045-1cqqj84n	285	9	,	,	,
cord-012045-1cqqj84n	285	10	which	which	WDT
cord-012045-1cqqj84n	285	11	reminds	remind	VBZ
cord-012045-1cqqj84n	285	12	us	-PRON-	PRP
cord-012045-1cqqj84n	285	13	of	of	IN
cord-012045-1cqqj84n	285	14	the	the	DT
cord-012045-1cqqj84n	285	15	potential	potential	JJ
cord-012045-1cqqj84n	285	16	drug	drug	NN
cord-012045-1cqqj84n	285	17	target	target	NN
cord-012045-1cqqj84n	285	18	for	for	IN
cord-012045-1cqqj84n	285	19	the	the	DT
cord-012045-1cqqj84n	285	20	treatment	treatment	NN
cord-012045-1cqqj84n	285	21	of	of	IN
cord-012045-1cqqj84n	285	22	virus	virus	NN
cord-012045-1cqqj84n	285	23	-	-	HYPH
cord-012045-1cqqj84n	285	24	induced	induce	VBN
cord-012045-1cqqj84n	285	25	lung	lung	NN
cord-012045-1cqqj84n	285	26	injury	injury	NN
cord-012045-1cqqj84n	285	27	.	.	.
cord-012045-1cqqj84n	286	1	The	the	DT
cord-012045-1cqqj84n	286	2	JAMMs	jamm	NNS
cord-012045-1cqqj84n	286	3	are	be	VBP
cord-012045-1cqqj84n	286	4	the	the	DT
cord-012045-1cqqj84n	286	5	third	third	RB
cord-012045-1cqqj84n	286	6	largest	large	JJS
cord-012045-1cqqj84n	286	7	subfamily	subfamily	NN
cord-012045-1cqqj84n	286	8	in	in	IN
cord-012045-1cqqj84n	286	9	DUBs	dub	NNS
cord-012045-1cqqj84n	286	10	,	,	,
cord-012045-1cqqj84n	286	11	and	and	CC
cord-012045-1cqqj84n	286	12	it	-PRON-	PRP
cord-012045-1cqqj84n	286	13	comprises	comprise	VBZ
cord-012045-1cqqj84n	286	14	12	12	CD
cord-012045-1cqqj84n	286	15	members	member	NNS
cord-012045-1cqqj84n	286	16	:	:	:
cord-012045-1cqqj84n	287	1	COP9	COP9	NNP
cord-012045-1cqqj84n	287	2	signalosome	signalosome	NN
cord-012045-1cqqj84n	287	3	subunit	subunit	NNP
cord-012045-1cqqj84n	287	4	(	(	-LRB-
cord-012045-1cqqj84n	287	5	CSN)5	CSN)5	NNP
cord-012045-1cqqj84n	287	6	,	,	,
cord-012045-1cqqj84n	287	7	26S	26S	NNP
cord-012045-1cqqj84n	287	8	proteasome	proteasome	VBD
cord-012045-1cqqj84n	287	9	non	non	JJ
cord-012045-1cqqj84n	287	10	-	-	JJ
cord-012045-1cqqj84n	287	11	ATPase	atpase	JJ
cord-012045-1cqqj84n	287	12	regulatory	regulatory	JJ
cord-012045-1cqqj84n	287	13	subunit	subunit	NN
cord-012045-1cqqj84n	287	14	14	14	CD
cord-012045-1cqqj84n	287	15	(	(	-LRB-
cord-012045-1cqqj84n	287	16	POH1	POH1	NNP
cord-012045-1cqqj84n	287	17	)	)	-RRB-
cord-012045-1cqqj84n	287	18	,	,	,
cord-012045-1cqqj84n	287	19	BRCA1	BRCA1	NNP
cord-012045-1cqqj84n	287	20	/	/	SYM
cord-012045-1cqqj84n	287	21	BRCA2-containing	BRCA2-containing	NNP
cord-012045-1cqqj84n	288	1	complex	complex	NNP
cord-012045-1cqqj84n	288	2	subunit	subunit	NN
cord-012045-1cqqj84n	288	3	3	3	CD
cord-012045-1cqqj84n	289	1	(	(	-LRB-
cord-012045-1cqqj84n	289	2	BRCC3	BRCC3	NNP
cord-012045-1cqqj84n	289	3	,	,	,
cord-012045-1cqqj84n	289	4	also	also	RB
cord-012045-1cqqj84n	289	5	known	know	VBN
cord-012045-1cqqj84n	289	6	as	as	IN
cord-012045-1cqqj84n	289	7	BRCC36	BRCC36	NNP
cord-012045-1cqqj84n	289	8	in	in	IN
cord-012045-1cqqj84n	289	9	humans	human	NNS
cord-012045-1cqqj84n	289	10	)	)	-RRB-
cord-012045-1cqqj84n	289	11	,	,	,
cord-012045-1cqqj84n	289	12	MPN	MPN	NNP
cord-012045-1cqqj84n	289	13	domain	domain	NN
cord-012045-1cqqj84n	289	14	containing	contain	VBG
cord-012045-1cqqj84n	289	15	(	(	-LRB-
cord-012045-1cqqj84n	289	16	MPND	MPND	NNP
cord-012045-1cqqj84n	289	17	,	,	,
cord-012045-1cqqj84n	289	18	myb	myb	NN
cord-012045-1cqqj84n	289	19	-	-	HYPH
cord-012045-1cqqj84n	289	20	like	like	JJ
cord-012045-1cqqj84n	289	21	SWIRM	SWIRM	NNP
cord-012045-1cqqj84n	289	22	and	and	CC
cord-012045-1cqqj84n	289	23	MPN	MPN	NNP
cord-012045-1cqqj84n	289	24	domains	domain	NNS
cord-012045-1cqqj84n	289	25	1	1	CD
cord-012045-1cqqj84n	289	26	(	(	-LRB-
cord-012045-1cqqj84n	289	27	MYSM1	MYSM1	NNP
cord-012045-1cqqj84n	289	28	)	)	-RRB-
cord-012045-1cqqj84n	289	29	,	,	,
cord-012045-1cqqj84n	289	30	eukaryotic	eukaryotic	JJ
cord-012045-1cqqj84n	289	31	translation	translation	NN
cord-012045-1cqqj84n	289	32	initiation	initiation	NN
cord-012045-1cqqj84n	289	33	factor	factor	NN
cord-012045-1cqqj84n	289	34	3	3	CD
cord-012045-1cqqj84n	289	35	subunit	subunit	NN
cord-012045-1cqqj84n	289	36	(	(	-LRB-
cord-012045-1cqqj84n	289	37	EIF3)H	EIF3)H	NNP
cord-012045-1cqqj84n	289	38	,	,	,
cord-012045-1cqqj84n	289	39	CSN6,26S	CSN6,26S	NNP
cord-012045-1cqqj84n	289	40	proteasome	proteasome	VBD
cord-012045-1cqqj84n	289	41	non	non	JJ
cord-012045-1cqqj84n	289	42	-	-	JJ
cord-012045-1cqqj84n	289	43	ATPase	atpase	JJ
cord-012045-1cqqj84n	289	44	regulatory	regulatory	JJ
cord-012045-1cqqj84n	289	45	subunit	subunit	NN
cord-012045-1cqqj84n	289	46	7	7	CD
cord-012045-1cqqj84n	289	47	(	(	-LRB-
cord-012045-1cqqj84n	289	48	PSMD7	PSMD7	NNP
cord-012045-1cqqj84n	289	49	)	)	-RRB-
cord-012045-1cqqj84n	289	50	,	,	,
cord-012045-1cqqj84n	289	51	EIF3F	EIF3F	NNP
cord-012045-1cqqj84n	289	52	,	,	,
cord-012045-1cqqj84n	289	53	anti	anti	JJ
cord-012045-1cqqj84n	289	54	-	-	JJ
cord-012045-1cqqj84n	289	55	Müllerian	müllerian	JJ
cord-012045-1cqqj84n	289	56	hormone	hormone	NN
cord-012045-1cqqj84n	289	57	(	(	-LRB-
cord-012045-1cqqj84n	289	58	AMSH	AMSH	NNP
cord-012045-1cqqj84n	289	59	)	)	-RRB-
cord-012045-1cqqj84n	289	60	,	,	,
cord-012045-1cqqj84n	289	61	AMSH	AMSH	NNP
cord-012045-1cqqj84n	289	62	-	-	HYPH
cord-012045-1cqqj84n	289	63	LP	LP	NNP
cord-012045-1cqqj84n	289	64	,	,	,
cord-012045-1cqqj84n	289	65	and	and	CC
cord-012045-1cqqj84n	289	66	pre	pre	JJ
cord-012045-1cqqj84n	289	67	-	-	JJ
cord-012045-1cqqj84n	289	68	mRNA	mrna	JJ
cord-012045-1cqqj84n	289	69	-	-	HYPH
cord-012045-1cqqj84n	289	70	processing	processing	NN
cord-012045-1cqqj84n	289	71	-	-	HYPH
cord-012045-1cqqj84n	289	72	splicing	splicing	NN
cord-012045-1cqqj84n	289	73	factor	factor	NN
cord-012045-1cqqj84n	289	74	8	8	CD
cord-012045-1cqqj84n	289	75	(	(	-LRB-
cord-012045-1cqqj84n	289	76	PRPF8	PRPF8	NNP
cord-012045-1cqqj84n	289	77	)	)	-RRB-
cord-012045-1cqqj84n	289	78	[	[	-LRB-
cord-012045-1cqqj84n	289	79	93	93	CD
cord-012045-1cqqj84n	289	80	,	,	,
cord-012045-1cqqj84n	289	81	[	[	-LRB-
cord-012045-1cqqj84n	289	82	136	136	CD
cord-012045-1cqqj84n	289	83	]	]	-RRB-
cord-012045-1cqqj84n	289	84	[	[	-LRB-
cord-012045-1cqqj84n	289	85	137	137	CD
cord-012045-1cqqj84n	289	86	]	]	-RRB-
cord-012045-1cqqj84n	289	87	[	[	-LRB-
cord-012045-1cqqj84n	289	88	138	138	CD
cord-012045-1cqqj84n	289	89	]	]	-RRB-
cord-012045-1cqqj84n	289	90	[	[	-LRB-
cord-012045-1cqqj84n	289	91	139	139	CD
cord-012045-1cqqj84n	289	92	]	]	-RRB-
cord-012045-1cqqj84n	289	93	.STAMBP	.STAMBP	.
cord-012045-1cqqj84n	290	1	(	(	-LRB-
cord-012045-1cqqj84n	290	2	also	also	RB
cord-012045-1cqqj84n	290	3	known	know	VBN
cord-012045-1cqqj84n	290	4	as	as	IN
cord-012045-1cqqj84n	290	5	the	the	DT
cord-012045-1cqqj84n	290	6	associated	associate	VBN
cord-012045-1cqqj84n	290	7	molecule	molecule	NN
cord-012045-1cqqj84n	290	8	with	with	IN
cord-012045-1cqqj84n	290	9	the	the	DT
cord-012045-1cqqj84n	290	10	SH3	SH3	NNP
cord-012045-1cqqj84n	290	11	domain	domain	NN
cord-012045-1cqqj84n	290	12	of	of	IN
cord-012045-1cqqj84n	290	13	STAM	STAM	NNP
cord-012045-1cqqj84n	290	14	or	or	CC
cord-012045-1cqqj84n	290	15	AMSH	AMSH	NNP
cord-012045-1cqqj84n	290	16	)	)	-RRB-
cord-012045-1cqqj84n	290	17	,	,	,
cord-012045-1cqqj84n	290	18	a	a	DT
cord-012045-1cqqj84n	290	19	metalloprotease	metalloprotease	NN
cord-012045-1cqqj84n	290	20	and	and	CC
cord-012045-1cqqj84n	290	21	a	a	DT
cord-012045-1cqqj84n	290	22	member	member	NN
cord-012045-1cqqj84n	290	23	of	of	IN
cord-012045-1cqqj84n	290	24	the	the	DT
cord-012045-1cqqj84n	290	25	Jab1	Jab1	NNP
cord-012045-1cqqj84n	290	26	/	/	SYM
cord-012045-1cqqj84n	290	27	MPN	MPN	NNP
cord-012045-1cqqj84n	290	28	metalloenzyme	metalloenzyme	NNS
cord-012045-1cqqj84n	290	29	(	(	-LRB-
cord-012045-1cqqj84n	290	30	JAMM	JAMM	NNP
cord-012045-1cqqj84n	290	31	)	)	-RRB-
cord-012045-1cqqj84n	290	32	family	family	NN
cord-012045-1cqqj84n	290	33	of	of	IN
cord-012045-1cqqj84n	290	34	DUBs	dub	NNS
cord-012045-1cqqj84n	290	35	,	,	,
cord-012045-1cqqj84n	290	36	impedes	impede	VBZ
cord-012045-1cqqj84n	290	37	the	the	DT
cord-012045-1cqqj84n	290	38	lysosomal	lysosomal	JJ
cord-012045-1cqqj84n	290	39	degradation	degradation	NN
cord-012045-1cqqj84n	290	40	of	of	IN
cord-012045-1cqqj84n	290	41	NACHT	NACHT	NNP
cord-012045-1cqqj84n	290	42	,	,	,
cord-012045-1cqqj84n	290	43	LRR	LRR	NNP
cord-012045-1cqqj84n	290	44	and	and	CC
cord-012045-1cqqj84n	290	45	PYD	PYD	NNP
cord-012045-1cqqj84n	290	46	domain	domain	NN
cord-012045-1cqqj84n	290	47	-	-	HYPH
cord-012045-1cqqj84n	290	48	containing	contain	VBG
cord-012045-1cqqj84n	290	49	protein	protein	NN
cord-012045-1cqqj84n	290	50	7	7	CD
cord-012045-1cqqj84n	291	1	(	(	-LRB-
cord-012045-1cqqj84n	291	2	NALP7)to	NALP7)to	NNP
cord-012045-1cqqj84n	291	3	inhibit	inhibit	VB
cord-012045-1cqqj84n	291	4	inflammasome	inflammasome	NN
cord-012045-1cqqj84n	291	5	activity	activity	NN
cord-012045-1cqqj84n	291	6	[	[	-LRB-
cord-012045-1cqqj84n	291	7	95	95	CD
cord-012045-1cqqj84n	291	8	,	,	,
cord-012045-1cqqj84n	291	9	140	140	CD
cord-012045-1cqqj84n	291	10	]	]	-RRB-
cord-012045-1cqqj84n	291	11	.	.	.
cord-012045-1cqqj84n	292	1	POH1	POH1	NNP
cord-012045-1cqqj84n	292	2	deubiquitinates	deubiquitinate	NNS
cord-012045-1cqqj84n	292	3	pro	pro	JJ
cord-012045-1cqqj84n	292	4	-	-	JJ
cord-012045-1cqqj84n	292	5	IL-1β	il-1β	JJ
cord-012045-1cqqj84n	292	6	and	and	CC
cord-012045-1cqqj84n	292	7	inhibits	inhibit	VBZ
cord-012045-1cqqj84n	292	8	mature	mature	JJ
cord-012045-1cqqj84n	292	9	IL-1β	il-1β	JJ
cord-012045-1cqqj84n	292	10	production	production	NN
cord-012045-1cqqj84n	292	11	,	,	,
cord-012045-1cqqj84n	292	12	thus	thus	RB
cord-012045-1cqqj84n	292	13	restricting	restrict	VBG
cord-012045-1cqqj84n	292	14	inflammasome	inflammasome	NN
cord-012045-1cqqj84n	292	15	activity	activity	NN
cord-012045-1cqqj84n	292	16	and	and	CC
cord-012045-1cqqj84n	292	17	LPS	LPS	NNP
cord-012045-1cqqj84n	292	18	-	-	HYPH
cord-012045-1cqqj84n	292	19	induced	induce	VBN
cord-012045-1cqqj84n	292	20	inflammation	inflammation	NN
cord-012045-1cqqj84n	292	21	[	[	-LRB-
cord-012045-1cqqj84n	292	22	93	93	CD
cord-012045-1cqqj84n	292	23	]	]	-RRB-
cord-012045-1cqqj84n	292	24	.	.	.
cord-012045-1cqqj84n	293	1	DUBBRCC3	DUBBRCC3	NNP
cord-012045-1cqqj84n	293	2	forms	form	VBZ
cord-012045-1cqqj84n	293	3	a	a	DT
cord-012045-1cqqj84n	293	4	multi	multi	JJ
cord-012045-1cqqj84n	293	5	-	-	JJ
cord-012045-1cqqj84n	293	6	protein	protein	JJ
cord-012045-1cqqj84n	293	7	complex	complex	NN
cord-012045-1cqqj84n	293	8	(	(	-LRB-
cord-012045-1cqqj84n	293	9	BRISC	BRISC	NNP
cord-012045-1cqqj84n	293	10	)	)	-RRB-
cord-012045-1cqqj84n	293	11	with	with	IN
cord-012045-1cqqj84n	293	12	ABRO1	ABRO1	NNP
cord-012045-1cqqj84n	293	13	,	,	,
cord-012045-1cqqj84n	293	14	NBA1	NBA1	NNP
cord-012045-1cqqj84n	293	15	,	,	,
cord-012045-1cqqj84n	293	16	and	and	CC
cord-012045-1cqqj84n	293	17	BRE	BRE	NNP
cord-012045-1cqqj84n	293	18	that	that	WDT
cord-012045-1cqqj84n	293	19	specifically	specifically	RB
cord-012045-1cqqj84n	293	20	cleaves	cleave	VBZ
cord-012045-1cqqj84n	293	21	K63-linked	K63-linked	NNP
cord-012045-1cqqj84n	293	22	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	293	23	in	in	IN
cord-012045-1cqqj84n	293	24	the	the	DT
cord-012045-1cqqj84n	293	25	cytoplasm	cytoplasm	NN
cord-012045-1cqqj84n	293	26	[	[	-LRB-
cord-012045-1cqqj84n	293	27	141	141	CD
cord-012045-1cqqj84n	293	28	]	]	-RRB-
cord-012045-1cqqj84n	293	29	.	.	.
cord-012045-1cqqj84n	294	1	ABRO1	ABRO1	NNP
cord-012045-1cqqj84n	294	2	is	be	VBZ
cord-012045-1cqqj84n	294	3	important	important	JJ
cord-012045-1cqqj84n	294	4	in	in	IN
cord-012045-1cqqj84n	294	5	efficient	efficient	JJ
cord-012045-1cqqj84n	294	6	NLRP3	nlrp3	NN
cord-012045-1cqqj84n	294	7	activation	activation	NN
cord-012045-1cqqj84n	294	8	.	.	.
cord-012045-1cqqj84n	295	1	ABRO1	ABRO1	NNP
cord-012045-1cqqj84n	295	2	deubiquitinates	deubiquitinate	VBZ
cord-012045-1cqqj84n	295	3	NLRP3	NLRP3	NNP
cord-012045-1cqqj84n	296	1	to	to	TO
cord-012045-1cqqj84n	296	2	promote	promote	VB
cord-012045-1cqqj84n	296	3	NLRP3	NLRP3	NNP
cord-012045-1cqqj84n	296	4	inflammasome	inflammasome	NNP
cord-012045-1cqqj84n	296	5	activation	activation	NN
cord-012045-1cqqj84n	296	6	[	[	-LRB-
cord-012045-1cqqj84n	296	7	98	98	CD
cord-012045-1cqqj84n	296	8	]	]	-RRB-
cord-012045-1cqqj84n	296	9	.	.	.
cord-012045-1cqqj84n	297	1	BRCC3	BRCC3	NNP
cord-012045-1cqqj84n	297	2	also	also	RB
cord-012045-1cqqj84n	297	3	targets	target	VBZ
cord-012045-1cqqj84n	297	4	NLRP2	nlrp2	NN
cord-012045-1cqqj84n	297	5	to	to	TO
cord-012045-1cqqj84n	297	6	regulate	regulate	VB
cord-012045-1cqqj84n	297	7	inflammasome	inflammasome	NN
cord-012045-1cqqj84n	297	8	formation	formation	NN
cord-012045-1cqqj84n	297	9	[	[	-LRB-
cord-012045-1cqqj84n	297	10	94	94	CD
cord-012045-1cqqj84n	297	11	]	]	-RRB-
cord-012045-1cqqj84n	297	12	.	.	.
cord-012045-1cqqj84n	298	1	The	the	DT
cord-012045-1cqqj84n	298	2	enzymes	enzyme	NNS
cord-012045-1cqqj84n	298	3	of	of	IN
cord-012045-1cqqj84n	298	4	the	the	DT
cord-012045-1cqqj84n	298	5	UCH	UCH	NNP
cord-012045-1cqqj84n	298	6	protein	protein	NN
cord-012045-1cqqj84n	298	7	family	family	NN
cord-012045-1cqqj84n	298	8	includes	include	VBZ
cord-012045-1cqqj84n	298	9	four	four	CD
cord-012045-1cqqj84n	298	10	members	member	NNS
cord-012045-1cqqj84n	298	11	,	,	,
cord-012045-1cqqj84n	298	12	UCHL1/	UCHL1/	NNS
cord-012045-1cqqj84n	299	1	PGP9.5	PGP9.5	NNP
cord-012045-1cqqj84n	299	2	(	(	-LRB-
cord-012045-1cqqj84n	299	3	protein	protein	NN
cord-012045-1cqqj84n	299	4	gene	gene	NN
cord-012045-1cqqj84n	299	5	product	product	NN
cord-012045-1cqqj84n	299	6	9.5	9.5	CD
cord-012045-1cqqj84n	299	7	)	)	-RRB-
cord-012045-1cqqj84n	299	8	,	,	,
cord-012045-1cqqj84n	299	9	UCHL3	UCHL3	NNP
cord-012045-1cqqj84n	299	10	,	,	,
cord-012045-1cqqj84n	299	11	UCHL5	UCHL5	NNP
cord-012045-1cqqj84n	299	12	/	/	SYM
cord-012045-1cqqj84n	299	13	UCH37	UCH37	NNP
cord-012045-1cqqj84n	299	14	,	,	,
cord-012045-1cqqj84n	299	15	and	and	CC
cord-012045-1cqqj84n	299	16	BRCA1	BRCA1	NNP
cord-012045-1cqqj84n	299	17	associated	associated	NNP
cord-012045-1cqqj84n	299	18	protein-1(BAP1	protein-1(BAP1	NNP
cord-012045-1cqqj84n	299	19	)	)	-RRB-
cord-012045-1cqqj84n	299	20	,	,	,
cord-012045-1cqqj84n	299	21	which	which	WDT
cord-012045-1cqqj84n	299	22	contain	contain	VBP
cord-012045-1cqqj84n	299	23	a	a	DT
cord-012045-1cqqj84n	299	24	conserved	conserved	JJ
cord-012045-1cqqj84n	299	25	catalytic	catalytic	JJ
cord-012045-1cqqj84n	299	26	UCH	UCH	NNP
cord-012045-1cqqj84n	299	27	domain	domain	NN
cord-012045-1cqqj84n	299	28	of~230	of~230	CD
cord-012045-1cqqj84n	299	29	amino	amino	NN
cord-012045-1cqqj84n	299	30	acids	acid	NNS
cord-012045-1cqqj84n	299	31	[	[	-LRB-
cord-012045-1cqqj84n	299	32	142	142	CD
cord-012045-1cqqj84n	299	33	,	,	,
cord-012045-1cqqj84n	299	34	143	143	CD
cord-012045-1cqqj84n	299	35	]	]	-RRB-
cord-012045-1cqqj84n	299	36	.	.	.
cord-012045-1cqqj84n	300	1	The	the	DT
cord-012045-1cqqj84n	300	2	activities	activity	NNS
cord-012045-1cqqj84n	300	3	of	of	IN
cord-012045-1cqqj84n	300	4	these	these	DT
cord-012045-1cqqj84n	300	5	proteins	protein	NNS
cord-012045-1cqqj84n	300	6	have	have	VBP
cord-012045-1cqqj84n	300	7	been	be	VBN
cord-012045-1cqqj84n	300	8	associated	associate	VBN
cord-012045-1cqqj84n	300	9	with	with	IN
cord-012045-1cqqj84n	300	10	the	the	DT
cord-012045-1cqqj84n	300	11	occurrence	occurrence	NN
cord-012045-1cqqj84n	300	12	and	and	CC
cord-012045-1cqqj84n	300	13	development	development	NN
cord-012045-1cqqj84n	300	14	of	of	IN
cord-012045-1cqqj84n	300	15	cancer	cancer	NN
cord-012045-1cqqj84n	300	16	[	[	-LRB-
cord-012045-1cqqj84n	300	17	143	143	CD
cord-012045-1cqqj84n	300	18	]	]	-RRB-
cord-012045-1cqqj84n	300	19	.	.	.
cord-012045-1cqqj84n	301	1	UCHL5	UCHL5	NNP
cord-012045-1cqqj84n	301	2	/	/	SYM
cord-012045-1cqqj84n	301	3	UCH37	UCH37	NNP
cord-012045-1cqqj84n	301	4	is	be	VBZ
cord-012045-1cqqj84n	301	5	suggested	suggest	VBN
cord-012045-1cqqj84n	301	6	to	to	TO
cord-012045-1cqqj84n	301	7	play	play	VB
cord-012045-1cqqj84n	301	8	an	an	DT
cord-012045-1cqqj84n	301	9	anti	anti	JJ
cord-012045-1cqqj84n	301	10	-	-	JJ
cord-012045-1cqqj84n	301	11	apoptotic	apoptotic	JJ
cord-012045-1cqqj84n	301	12	role	role	NN
cord-012045-1cqqj84n	301	13	in	in	IN
cord-012045-1cqqj84n	301	14	lung	lung	NN
cord-012045-1cqqj84n	301	15	epithelial	epithelial	NN
cord-012045-1cqqj84n	301	16	cells	cell	NNS
cord-012045-1cqqj84n	301	17	through	through	IN
cord-012045-1cqqj84n	301	18	altering	alter	VBG
cord-012045-1cqqj84n	301	19	Bax	Bax	NNP
cord-012045-1cqqj84n	301	20	/	/	SYM
cord-012045-1cqqj84n	301	21	Bcl-2	Bcl-2	NNP
cord-012045-1cqqj84n	301	22	,	,	,
cord-012045-1cqqj84n	301	23	caspase	caspase	NN
cord-012045-1cqqj84n	301	24	3	3	CD
cord-012045-1cqqj84n	301	25	,	,	,
cord-012045-1cqqj84n	301	26	and	and	CC
cord-012045-1cqqj84n	301	27	caspase9	caspase9	NN
cord-012045-1cqqj84n	301	28	signals	signal	NNS
cord-012045-1cqqj84n	301	29	[	[	-LRB-
cord-012045-1cqqj84n	301	30	144	144	CD
cord-012045-1cqqj84n	301	31	]	]	-RRB-
cord-012045-1cqqj84n	301	32	.	.	.
cord-012045-1cqqj84n	302	1	UCH5	UCH5	NNP
cord-012045-1cqqj84n	302	2	/	/	SYM
cord-012045-1cqqj84n	302	3	UCH37	UCH37	NNP
cord-012045-1cqqj84n	302	4	deubiquitinates	deubiquitinates	NNP
cord-012045-1cqqj84n	302	5	both	both	DT
cord-012045-1cqqj84n	302	6	smad2	smad2	NNP
cord-012045-1cqqj84n	302	7	and	and	CC
cord-012045-1cqqj84n	302	8	smad3	smad3	NN
cord-012045-1cqqj84n	302	9	to	to	TO
cord-012045-1cqqj84n	302	10	promote	promote	VB
cord-012045-1cqqj84n	302	11	TGFβ-1	TGFβ-1	NNP
cord-012045-1cqqj84n	302	12	induced	induce	VBN
cord-012045-1cqqj84n	302	13	lung	lung	NN
cord-012045-1cqqj84n	302	14	fibrosis	fibrosis	NN
cord-012045-1cqqj84n	302	15	[	[	-LRB-
cord-012045-1cqqj84n	302	16	70	70	CD
cord-012045-1cqqj84n	302	17	]	]	-RRB-
cord-012045-1cqqj84n	302	18	.	.	.
cord-012045-1cqqj84n	303	1	Studies	study	NNS
cord-012045-1cqqj84n	303	2	of	of	IN
cord-012045-1cqqj84n	303	3	UCHs	UCHs	NNP
cord-012045-1cqqj84n	303	4	in	in	IN
cord-012045-1cqqj84n	303	5	lung	lung	NN
cord-012045-1cqqj84n	303	6	injury	injury	NN
cord-012045-1cqqj84n	303	7	and	and	CC
cord-012045-1cqqj84n	303	8	pathogen	pathogen	NN
cord-012045-1cqqj84n	303	9	invasion	invasion	NN
cord-012045-1cqqj84n	303	10	are	be	VBP
cord-012045-1cqqj84n	303	11	still	still	RB
cord-012045-1cqqj84n	303	12	lacking	lack	VBG
cord-012045-1cqqj84n	303	13	.	.	.
cord-012045-1cqqj84n	304	1	The	the	DT
cord-012045-1cqqj84n	304	2	MJD	MJD	NNP
cord-012045-1cqqj84n	304	3	family	family	NN
cord-012045-1cqqj84n	304	4	onlycontains	onlycontain	VBZ
cord-012045-1cqqj84n	304	5	four	four	CD
cord-012045-1cqqj84n	304	6	members	member	NNS
cord-012045-1cqqj84n	304	7	:	:	:
cord-012045-1cqqj84n	304	8	Ataxin	Ataxin	NNP
cord-012045-1cqqj84n	304	9	(	(	-LRB-
cord-012045-1cqqj84n	304	10	ATXN)3	ATXN)3	NNP
cord-012045-1cqqj84n	304	11	,	,	,
cord-012045-1cqqj84n	304	12	ATXN3L	ATXN3L	NNP
cord-012045-1cqqj84n	304	13	,	,	,
cord-012045-1cqqj84n	304	14	Josephin	Josephin	NNP
cord-012045-1cqqj84n	304	15	domain	domain	NN
cord-012045-1cqqj84n	304	16	containing	contain	VBG
cord-012045-1cqqj84n	304	17	(	(	-LRB-
cord-012045-1cqqj84n	304	18	JOSD	JOSD	NNP
cord-012045-1cqqj84n	304	19	)	)	-RRB-
cord-012045-1cqqj84n	304	20	,	,	,
cord-012045-1cqqj84n	304	21	and	and	CC
cord-012045-1cqqj84n	304	22	JOSD2	josd2	XX
cord-012045-1cqqj84n	304	23	[	[	-LRB-
cord-012045-1cqqj84n	304	24	145	145	CD
cord-012045-1cqqj84n	304	25	]	]	-RRB-
cord-012045-1cqqj84n	304	26	.	.	.
cord-012045-1cqqj84n	305	1	Studies	study	NNS
cord-012045-1cqqj84n	305	2	show	show	VBP
cord-012045-1cqqj84n	305	3	that	that	IN
cord-012045-1cqqj84n	305	4	ATXN3	atxn3	NN
cord-012045-1cqqj84n	305	5	andJOSD1	andjosd1	CD
cord-012045-1cqqj84n	305	6	are	be	VBP
cord-012045-1cqqj84n	305	7	involved	involve	VBN
cord-012045-1cqqj84n	305	8	in	in	IN
cord-012045-1cqqj84n	305	9	antiviral	antiviral	JJ
cord-012045-1cqqj84n	305	10	responses	response	NNS
cord-012045-1cqqj84n	305	11	.	.	.
cord-012045-1cqqj84n	306	1	ATXN3	atxn3	NN
cord-012045-1cqqj84n	306	2	enhances	enhance	VBZ
cord-012045-1cqqj84n	306	3	type	type	NN
cord-012045-1cqqj84n	306	4	1	1	CD
cord-012045-1cqqj84n	306	5	IFN	IFN	NNP
cord-012045-1cqqj84n	306	6	signaling	signal	VBG
cord-012045-1cqqj84n	306	7	during	during	IN
cord-012045-1cqqj84n	306	8	viral	viral	JJ
cord-012045-1cqqj84n	306	9	infection	infection	NN
cord-012045-1cqqj84n	306	10	through	through	IN
cord-012045-1cqqj84n	306	11	deubiquitinating	deubiquitinating	NN
cord-012045-1cqqj84n	306	12	and	and	CC
cord-012045-1cqqj84n	306	13	stabilizing	stabilize	VBG
cord-012045-1cqqj84n	306	14	HDAC3	hdac3	XX
cord-012045-1cqqj84n	306	15	[	[	-LRB-
cord-012045-1cqqj84n	306	16	90	90	CD
cord-012045-1cqqj84n	306	17	]	]	-RRB-
cord-012045-1cqqj84n	306	18	.	.	.
cord-012045-1cqqj84n	307	1	Nevertheless	nevertheless	RB
cord-012045-1cqqj84n	307	2	,	,	,
cord-012045-1cqqj84n	307	3	JOSD1	josd1	XX
cord-012045-1cqqj84n	307	4	exhibits	exhibit	VBZ
cord-012045-1cqqj84n	307	5	a	a	DT
cord-012045-1cqqj84n	307	6	negative	negative	JJ
cord-012045-1cqqj84n	307	7	role	role	NN
cord-012045-1cqqj84n	307	8	in	in	IN
cord-012045-1cqqj84n	307	9	antiviral	antiviral	JJ
cord-012045-1cqqj84n	307	10	activity	activity	NN
cord-012045-1cqqj84n	307	11	.	.	.
cord-012045-1cqqj84n	308	1	JOSD1	JOSD1	NNP
cord-012045-1cqqj84n	308	2	inhibits	inhibit	VBZ
cord-012045-1cqqj84n	308	3	the	the	DT
cord-012045-1cqqj84n	308	4	IFN	IFN	NNP
cord-012045-1cqqj84n	308	5	signal	signal	NN
cord-012045-1cqqj84n	308	6	cascade	cascade	NN
cord-012045-1cqqj84n	308	7	via	via	IN
cord-012045-1cqqj84n	308	8	deubiquitinating	deubiquitinating	NN
cord-012045-1cqqj84n	308	9	and	and	CC
cord-012045-1cqqj84n	308	10	stabilizing	stabilize	VBG
cord-012045-1cqqj84n	308	11	SOCS1	SOCS1	NNP
cord-012045-1cqqj84n	308	12	[	[	-LRB-
cord-012045-1cqqj84n	308	13	92	92	CD
cord-012045-1cqqj84n	308	14	]	]	-RRB-
cord-012045-1cqqj84n	308	15	.	.	.
cord-012045-1cqqj84n	309	1	The	the	DT
cord-012045-1cqqj84n	309	2	MCPIP	MCPIP	NNP
cord-012045-1cqqj84n	309	3	,	,	,
cord-012045-1cqqj84n	309	4	also	also	RB
cord-012045-1cqqj84n	309	5	known	know	VBN
cord-012045-1cqqj84n	309	6	as	as	IN
cord-012045-1cqqj84n	309	7	ZC3H12A	ZC3H12A	NNP
cord-012045-1cqqj84n	310	1	(	(	-LRB-
cord-012045-1cqqj84n	310	2	zinc	zinc	NN
cord-012045-1cqqj84n	310	3	finger	finger	NN
cord-012045-1cqqj84n	310	4	CCCH	CCCH	NNS
cord-012045-1cqqj84n	310	5	-	-	HYPH
cord-012045-1cqqj84n	310	6	type	type	NN
cord-012045-1cqqj84n	310	7	containing	contain	VBG
cord-012045-1cqqj84n	310	8	12A	12a	CD
cord-012045-1cqqj84n	310	9	)	)	-RRB-
cord-012045-1cqqj84n	310	10	family	family	NN
cord-012045-1cqqj84n	310	11	includes	include	VBZ
cord-012045-1cqqj84n	310	12	MCPIP1	mcpip1	NN
cord-012045-1cqqj84n	310	13	-	-	SYM
cord-012045-1cqqj84n	310	14	7	7	CD
cord-012045-1cqqj84n	310	15	members	member	NNS
cord-012045-1cqqj84n	310	16	[	[	-LRB-
cord-012045-1cqqj84n	310	17	146	146	CD
cord-012045-1cqqj84n	310	18	]	]	-RRB-
cord-012045-1cqqj84n	310	19	[	[	-LRB-
cord-012045-1cqqj84n	310	20	147	147	CD
cord-012045-1cqqj84n	310	21	]	]	-RRB-
cord-012045-1cqqj84n	310	22	[	[	-LRB-
cord-012045-1cqqj84n	310	23	148	148	CD
cord-012045-1cqqj84n	310	24	]	]	-RRB-
cord-012045-1cqqj84n	310	25	.	.	.
cord-012045-1cqqj84n	311	1	MCPIP	MCPIP	NNP
cord-012045-1cqqj84n	311	2	implicates	implicate	VBZ
cord-012045-1cqqj84n	311	3	a	a	DT
cord-012045-1cqqj84n	311	4	negative	negative	JJ
cord-012045-1cqqj84n	311	5	role	role	NN
cord-012045-1cqqj84n	311	6	in	in	IN
cord-012045-1cqqj84n	311	7	regulation	regulation	NN
cord-012045-1cqqj84n	311	8	of	of	IN
cord-012045-1cqqj84n	311	9	the	the	DT
cord-012045-1cqqj84n	311	10	cellular	cellular	JJ
cord-012045-1cqqj84n	311	11	inflammatory	inflammatory	JJ
cord-012045-1cqqj84n	311	12	responses	response	NNS
cord-012045-1cqqj84n	311	13	[	[	-LRB-
cord-012045-1cqqj84n	311	14	149	149	CD
cord-012045-1cqqj84n	311	15	]	]	-RRB-
cord-012045-1cqqj84n	311	16	.	.	.
cord-012045-1cqqj84n	312	1	MCPIP1	MCPIP1	NNP
cord-012045-1cqqj84n	312	2	is	be	VBZ
cord-012045-1cqqj84n	312	3	the	the	DT
cord-012045-1cqqj84n	312	4	most	most	RBS
cord-012045-1cqqj84n	312	5	studied	study	VBN
cord-012045-1cqqj84n	312	6	in	in	IN
cord-012045-1cqqj84n	312	7	the	the	DT
cord-012045-1cqqj84n	312	8	MCPIP	MCPIP	NNP
cord-012045-1cqqj84n	312	9	family	family	NN
cord-012045-1cqqj84n	312	10	.	.	.
cord-012045-1cqqj84n	313	1	Acting	act	VBG
cord-012045-1cqqj84n	313	2	as	as	IN
cord-012045-1cqqj84n	313	3	a	a	DT
cord-012045-1cqqj84n	313	4	deubiquitinating	deubiquitinating	NN
cord-012045-1cqqj84n	313	5	enzyme	enzyme	NN
cord-012045-1cqqj84n	313	6	,	,	,
cord-012045-1cqqj84n	313	7	MCPIP1	MCPIP1	NNP
cord-012045-1cqqj84n	313	8	inhibits	inhibit	VBZ
cord-012045-1cqqj84n	313	9	NF	nf	NN
cord-012045-1cqqj84n	313	10	-	-	HYPH
cord-012045-1cqqj84n	313	11	κB	κB	NNP
cord-012045-1cqqj84n	313	12	and	and	CC
cord-012045-1cqqj84n	313	13	c	c	NNP
cord-012045-1cqqj84n	313	14	-	-	:
cord-012045-1cqqj84n	313	15	Jun	Jun	NNP
cord-012045-1cqqj84n	313	16	N	N	NNP
cord-012045-1cqqj84n	313	17	-	-	HYPH
cord-012045-1cqqj84n	313	18	terminal	terminal	NN
cord-012045-1cqqj84n	313	19	kinase	kinase	NN
cord-012045-1cqqj84n	313	20	(	(	-LRB-
cord-012045-1cqqj84n	313	21	JNK	JNK	NNP
cord-012045-1cqqj84n	313	22	)	)	-RRB-
cord-012045-1cqqj84n	313	23	signaling	signal	VBG
cord-012045-1cqqj84n	313	24	pathways	pathway	NNS
cord-012045-1cqqj84n	313	25	by	by	IN
cord-012045-1cqqj84n	313	26	removing	remove	VBG
cord-012045-1cqqj84n	313	27	the	the	DT
cord-012045-1cqqj84n	313	28	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	313	29	moieties	moiety	NNS
cord-012045-1cqqj84n	313	30	from	from	IN
cord-012045-1cqqj84n	313	31	TNF	TNF	NNP
cord-012045-1cqqj84n	313	32	receptor	receptor	NN
cord-012045-1cqqj84n	313	33	-	-	HYPH
cord-012045-1cqqj84n	313	34	associated	associate	VBN
cord-012045-1cqqj84n	313	35	factors	factor	NNS
cord-012045-1cqqj84n	313	36	(	(	-LRB-
cord-012045-1cqqj84n	313	37	TRAFs	TRAFs	NNP
cord-012045-1cqqj84n	313	38	)	)	-RRB-
cord-012045-1cqqj84n	313	39	,	,	,
cord-012045-1cqqj84n	313	40	including	include	VBG
cord-012045-1cqqj84n	313	41	TRAF2	TRAF2	NNP
cord-012045-1cqqj84n	313	42	,	,	,
cord-012045-1cqqj84n	313	43	TRAF3	TRAF3	NNP
cord-012045-1cqqj84n	313	44	and	and	CC
cord-012045-1cqqj84n	313	45	TRAF6	TRAF6	NNP
cord-012045-1cqqj84n	314	1	[	[	-LRB-
cord-012045-1cqqj84n	314	2	150	150	CD
cord-012045-1cqqj84n	314	3	]	]	-RRB-
cord-012045-1cqqj84n	314	4	.As	.As	.
cord-012045-1cqqj84n	315	1	an	an	DT
cord-012045-1cqqj84n	315	2	RNase	rnase	NN
cord-012045-1cqqj84n	315	3	,	,	,
cord-012045-1cqqj84n	315	4	MCPIP	MCPIP	NNP
cord-012045-1cqqj84n	315	5	also	also	RB
cord-012045-1cqqj84n	315	6	regulates	regulate	VBZ
cord-012045-1cqqj84n	315	7	inflammatory	inflammatory	JJ
cord-012045-1cqqj84n	315	8	cytokines	cytokine	NNS
cord-012045-1cqqj84n	315	9	like	like	IN
cord-012045-1cqqj84n	315	10	IL-6	IL-6	NNP
cord-012045-1cqqj84n	315	11	by	by	IN
cord-012045-1cqqj84n	315	12	regulating	regulate	VBG
cord-012045-1cqqj84n	315	13	RNA	RNA	NNP
cord-012045-1cqqj84n	315	14	decay	decay	NN
cord-012045-1cqqj84n	315	15	[	[	-LRB-
cord-012045-1cqqj84n	315	16	151	151	CD
cord-012045-1cqqj84n	315	17	]	]	-RRB-
cord-012045-1cqqj84n	315	18	and	and	CC
cord-012045-1cqqj84n	315	19	innate	innate	JJ
cord-012045-1cqqj84n	315	20	defense	defense	NN
cord-012045-1cqqj84n	315	21	via	via	IN
cord-012045-1cqqj84n	315	22	degrading	degrade	VBG
cord-012045-1cqqj84n	315	23	viral	viral	JJ
cord-012045-1cqqj84n	315	24	RNA	RNA	NNP
cord-012045-1cqqj84n	315	25	[	[	-LRB-
cord-012045-1cqqj84n	315	26	152	152	CD
cord-012045-1cqqj84n	315	27	]	]	-RRB-
cord-012045-1cqqj84n	315	28	.	.	.
cord-012045-1cqqj84n	316	1	MCPIP	MCPIP	NNP
cord-012045-1cqqj84n	316	2	deubiquitinates	deubiquitinates	NNP
cord-012045-1cqqj84n	316	3	TRAF6	TRAF6	NNP
cord-012045-1cqqj84n	317	1	to	to	TO
cord-012045-1cqqj84n	317	2	impede	impede	VB
cord-012045-1cqqj84n	318	1	NF	NF	NNP
cord-012045-1cqqj84n	318	2	-	-	HYPH
cord-012045-1cqqj84n	318	3	κB	κB	NNP
cord-012045-1cqqj84n	318	4	signaling	signal	VBG
cord-012045-1cqqj84n	318	5	[	[	-LRB-
cord-012045-1cqqj84n	318	6	89	89	CD
cord-012045-1cqqj84n	318	7	]	]	-RRB-
cord-012045-1cqqj84n	318	8	.	.	.
cord-012045-1cqqj84n	319	1	Like	like	IN
cord-012045-1cqqj84n	319	2	the	the	DT
cord-012045-1cqqj84n	319	3	recently	recently	RB
cord-012045-1cqqj84n	319	4	identified	identify	VBN
cord-012045-1cqqj84n	319	5	DUBs	dub	NNS
cord-012045-1cqqj84n	319	6	,	,	,
cord-012045-1cqqj84n	319	7	the	the	DT
cord-012045-1cqqj84n	319	8	MINDY	MINDY	NNP
cord-012045-1cqqj84n	319	9	family	family	NN
cord-012045-1cqqj84n	319	10	contains	contain	VBZ
cord-012045-1cqqj84n	319	11	four	four	CD
cord-012045-1cqqj84n	319	12	members	member	NNS
cord-012045-1cqqj84n	319	13	:	:	:
cord-012045-1cqqj84n	319	14	MINDY1	MINDY1	NNP
cord-012045-1cqqj84n	319	15	-	-	SYM
cord-012045-1cqqj84n	319	16	4	4	CD
cord-012045-1cqqj84n	319	17	[	[	-LRB-
cord-012045-1cqqj84n	319	18	145	145	CD
cord-012045-1cqqj84n	319	19	]	]	-RRB-
cord-012045-1cqqj84n	319	20	,	,	,
cord-012045-1cqqj84n	319	21	which	which	WDT
cord-012045-1cqqj84n	319	22	are	be	VBP
cord-012045-1cqqj84n	319	23	highly	highly	RB
cord-012045-1cqqj84n	319	24	selective	selective	JJ
cord-012045-1cqqj84n	319	25	at	at	IN
cord-012045-1cqqj84n	319	26	hydrolyzing	hydrolyze	VBG
cord-012045-1cqqj84n	319	27	K48-linked	K48-linked	NNP
cord-012045-1cqqj84n	319	28	poly	poly	NNP
cord-012045-1cqqj84n	319	29	-	-	HYPH
cord-012045-1cqqj84n	319	30	ubiquitin	ubiquitin	JJ
cord-012045-1cqqj84n	319	31	.	.	.
cord-012045-1cqqj84n	320	1	No	no	DT
cord-012045-1cqqj84n	320	2	data	datum	NNS
cord-012045-1cqqj84n	320	3	about	about	IN
cord-012045-1cqqj84n	320	4	MINDYs	MINDYs	NNP
cord-012045-1cqqj84n	320	5	in	in	IN
cord-012045-1cqqj84n	320	6	ALI	ALI	NNP
cord-012045-1cqqj84n	320	7	/	/	SYM
cord-012045-1cqqj84n	320	8	ARDS	ARDS	NNP
cord-012045-1cqqj84n	320	9	pathogenesis	pathogenesis	NN
cord-012045-1cqqj84n	320	10	has	have	VBZ
cord-012045-1cqqj84n	320	11	been	be	VBN
cord-012045-1cqqj84n	320	12	reported	report	VBN
cord-012045-1cqqj84n	320	13	.	.	.
cord-012045-1cqqj84n	321	1	The	the	DT
cord-012045-1cqqj84n	321	2	above	above	JJ
cord-012045-1cqqj84n	321	3	DUBs	dub	NNS
cord-012045-1cqqj84n	321	4	play	play	VBP
cord-012045-1cqqj84n	321	5	essential	essential	JJ
cord-012045-1cqqj84n	321	6	roles	role	NNS
cord-012045-1cqqj84n	321	7	in	in	IN
cord-012045-1cqqj84n	321	8	the	the	DT
cord-012045-1cqqj84n	321	9	initial	initial	JJ
cord-012045-1cqqj84n	321	10	development	development	NN
cord-012045-1cqqj84n	321	11	of	of	IN
cord-012045-1cqqj84n	321	12	cancer	cancer	NN
cord-012045-1cqqj84n	321	13	.	.	.
cord-012045-1cqqj84n	322	1	However	however	RB
cord-012045-1cqqj84n	322	2	,	,	,
cord-012045-1cqqj84n	322	3	their	-PRON-	PRP$
cord-012045-1cqqj84n	322	4	functions	function	NNS
cord-012045-1cqqj84n	322	5	in	in	IN
cord-012045-1cqqj84n	322	6	lung	lung	NN
cord-012045-1cqqj84n	322	7	injury	injury	NN
cord-012045-1cqqj84n	322	8	are	be	VBP
cord-012045-1cqqj84n	322	9	not	not	RB
cord-012045-1cqqj84n	322	10	fully	fully	RB
cord-012045-1cqqj84n	322	11	elucidated	elucidate	VBN
cord-012045-1cqqj84n	322	12	.	.	.
cord-012045-1cqqj84n	323	1	Pathogen	pathogen	NN
cord-012045-1cqqj84n	323	2	-	-	HYPH
cord-012045-1cqqj84n	323	3	related	relate	VBN
cord-012045-1cqqj84n	323	4	DUBs	dub	NNS
cord-012045-1cqqj84n	323	5	are	be	VBP
cord-012045-1cqqj84n	323	6	promising	promise	VBG
cord-012045-1cqqj84n	323	7	potential	potential	JJ
cord-012045-1cqqj84n	323	8	targets	target	NNS
cord-012045-1cqqj84n	323	9	of	of	IN
cord-012045-1cqqj84n	323	10	drug	drug	NN
cord-012045-1cqqj84n	323	11	discovery	discovery	NN
cord-012045-1cqqj84n	323	12	for	for	IN
cord-012045-1cqqj84n	323	13	human	human	JJ
cord-012045-1cqqj84n	323	14	pathogen	pathogen	NN
cord-012045-1cqqj84n	323	15	infection	infection	NN
cord-012045-1cqqj84n	323	16	and	and	CC
cord-012045-1cqqj84n	323	17	associated	associate	VBD
cord-012045-1cqqj84n	323	18	inflammatory	inflammatory	JJ
cord-012045-1cqqj84n	323	19	disorders	disorder	NNS
cord-012045-1cqqj84n	323	20	.	.	.
cord-012045-1cqqj84n	324	1	Bacteria	Bacteria	NNS
cord-012045-1cqqj84n	324	2	-	-	HYPH
cord-012045-1cqqj84n	324	3	encoded	encode	VBN
cord-012045-1cqqj84n	324	4	DUBs	dub	NNS
cord-012045-1cqqj84n	324	5	might	may	MD
cord-012045-1cqqj84n	324	6	promote	promote	VB
cord-012045-1cqqj84n	324	7	bacterial	bacterial	JJ
cord-012045-1cqqj84n	324	8	pathogenicity	pathogenicity	NN
cord-012045-1cqqj84n	324	9	through	through	IN
cord-012045-1cqqj84n	324	10	inhibiting	inhibit	VBG
cord-012045-1cqqj84n	324	11	the	the	DT
cord-012045-1cqqj84n	324	12	human	human	JJ
cord-012045-1cqqj84n	324	13	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	324	14	-	-	HYPH
cord-012045-1cqqj84n	324	15	proteasome	proteasome	VBN
cord-012045-1cqqj84n	324	16	system	system	NN
cord-012045-1cqqj84n	324	17	[	[	-LRB-
cord-012045-1cqqj84n	324	18	153	153	CD
cord-012045-1cqqj84n	324	19	]	]	-RRB-
cord-012045-1cqqj84n	324	20	.	.	.
cord-012045-1cqqj84n	325	1	Furthermore	furthermore	RB
cord-012045-1cqqj84n	325	2	,	,	,
cord-012045-1cqqj84n	325	3	viruses	virus	NNS
cord-012045-1cqqj84n	325	4	with	with	IN
cord-012045-1cqqj84n	325	5	genes	gene	NNS
cord-012045-1cqqj84n	325	6	for	for	IN
cord-012045-1cqqj84n	325	7	DUBs	dub	NNS
cord-012045-1cqqj84n	325	8	might	may	MD
cord-012045-1cqqj84n	325	9	inhibit	inhibit	VB
cord-012045-1cqqj84n	325	10	the	the	DT
cord-012045-1cqqj84n	325	11	antiviral	antiviral	JJ
cord-012045-1cqqj84n	325	12	pathways	pathway	NNS
cord-012045-1cqqj84n	325	13	using	use	VBG
cord-012045-1cqqj84n	325	14	a	a	DT
cord-012045-1cqqj84n	325	15	DUB	dub	NN
cord-012045-1cqqj84n	325	16	strategy	strategy	NN
cord-012045-1cqqj84n	325	17	to	to	TO
cord-012045-1cqqj84n	325	18	modulate	modulate	VB
cord-012045-1cqqj84n	325	19	protein	protein	NN
cord-012045-1cqqj84n	325	20	-	-	HYPH
cord-012045-1cqqj84n	325	21	protein	protein	NN
cord-012045-1cqqj84n	325	22	interactions	interaction	NNS
cord-012045-1cqqj84n	325	23	.	.	.
cord-012045-1cqqj84n	326	1	The	the	DT
cord-012045-1cqqj84n	326	2	SARS	SARS	NNP
cord-012045-1cqqj84n	326	3	-	-	HYPH
cord-012045-1cqqj84n	326	4	CoVPLpro	CoVPLpro	NNP
cord-012045-1cqqj84n	326	5	and	and	CC
cord-012045-1cqqj84n	326	6	MERS-	MERS-	NNP
cord-012045-1cqqj84n	327	1	CoVPLpro	CoVPLpro	NNP
cord-012045-1cqqj84n	328	1	papain	papain	NN
cord-012045-1cqqj84n	328	2	-	-	HYPH
cord-012045-1cqqj84n	328	3	like	like	JJ
cord-012045-1cqqj84n	328	4	cysteine	cysteine	NN
cord-012045-1cqqj84n	328	5	proteases	protease	NNS
cord-012045-1cqqj84n	328	6	have	have	VBP
cord-012045-1cqqj84n	328	7	been	be	VBN
cord-012045-1cqqj84n	328	8	reported	report	VBN
cord-012045-1cqqj84n	328	9	,	,	,
cord-012045-1cqqj84n	328	10	showing	show	VBG
cord-012045-1cqqj84n	328	11	a	a	DT
cord-012045-1cqqj84n	328	12	conserved	conserved	JJ
cord-012045-1cqqj84n	328	13	similar	similar	JJ
cord-012045-1cqqj84n	328	14	structure	structure	NN
cord-012045-1cqqj84n	328	15	to	to	IN
cord-012045-1cqqj84n	328	16	the	the	DT
cord-012045-1cqqj84n	328	17	USP	USP	NNP
cord-012045-1cqqj84n	328	18	family	family	NN
cord-012045-1cqqj84n	328	19	of	of	IN
cord-012045-1cqqj84n	328	20	DUBs	dub	NNS
cord-012045-1cqqj84n	328	21	by	by	IN
cord-012045-1cqqj84n	328	22	X	x	NN
cord-012045-1cqqj84n	328	23	-	-	NN
cord-012045-1cqqj84n	328	24	ray	ray	JJ
cord-012045-1cqqj84n	328	25	structure	structure	NN
cord-012045-1cqqj84n	328	26	,	,	,
cord-012045-1cqqj84n	328	27	which	which	WDT
cord-012045-1cqqj84n	328	28	shows	show	VBZ
cord-012045-1cqqj84n	328	29	the	the	DT
cord-012045-1cqqj84n	328	30	potential	potential	JJ
cord-012045-1cqqj84n	328	31	targets	target	NNS
cord-012045-1cqqj84n	328	32	of	of	IN
cord-012045-1cqqj84n	328	33	DUBs	dub	NNS
cord-012045-1cqqj84n	328	34	for	for	IN
cord-012045-1cqqj84n	328	35	antiviral	antiviral	JJ
cord-012045-1cqqj84n	328	36	drug	drug	NN
cord-012045-1cqqj84n	328	37	discovery	discovery	NN
cord-012045-1cqqj84n	328	38	[	[	-LRB-
cord-012045-1cqqj84n	328	39	154	154	CD
cord-012045-1cqqj84n	328	40	,	,	,
cord-012045-1cqqj84n	328	41	155	155	CD
cord-012045-1cqqj84n	328	42	]	]	-RRB-
cord-012045-1cqqj84n	328	43	.	.	.
cord-012045-1cqqj84n	329	1	In	in	IN
cord-012045-1cqqj84n	329	2	addition	addition	NN
cord-012045-1cqqj84n	329	3	,	,	,
cord-012045-1cqqj84n	329	4	several	several	JJ
cord-012045-1cqqj84n	329	5	RNA	RNA	NNP
cord-012045-1cqqj84n	329	6	virus	virus	NN
cord-012045-1cqqj84n	329	7	-	-	HYPH
cord-012045-1cqqj84n	329	8	related	relate	VBN
cord-012045-1cqqj84n	329	9	proteases	protease	NNS
cord-012045-1cqqj84n	329	10	containing	contain	VBG
cord-012045-1cqqj84n	329	11	the	the	DT
cord-012045-1cqqj84n	329	12	OUT	OUT	NNP
cord-012045-1cqqj84n	329	13	domain	domain	NN
cord-012045-1cqqj84n	329	14	can	can	MD
cord-012045-1cqqj84n	329	15	also	also	RB
cord-012045-1cqqj84n	329	16	remove	remove	VB
cord-012045-1cqqj84n	329	17	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	329	18	and	and	CC
cord-012045-1cqqj84n	329	19	ISG-15	ISG-15	NNP
cord-012045-1cqqj84n	329	20	signals	signal	NNS
cord-012045-1cqqj84n	329	21	from	from	IN
cord-012045-1cqqj84n	329	22	host	host	NN
cord-012045-1cqqj84n	329	23	cellular	cellular	JJ
cord-012045-1cqqj84n	329	24	proteins	protein	NNS
cord-012045-1cqqj84n	329	25	,	,	,
cord-012045-1cqqj84n	329	26	which	which	WDT
cord-012045-1cqqj84n	329	27	represents	represent	VBZ
cord-012045-1cqqj84n	329	28	a	a	DT
cord-012045-1cqqj84n	329	29	potential	potential	JJ
cord-012045-1cqqj84n	329	30	promising	promising	JJ
cord-012045-1cqqj84n	329	31	domain	domain	NN
cord-012045-1cqqj84n	329	32	for	for	IN
cord-012045-1cqqj84n	329	33	antiviral	antiviral	JJ
cord-012045-1cqqj84n	329	34	therapy	therapy	NN
cord-012045-1cqqj84n	329	35	[	[	-LRB-
cord-012045-1cqqj84n	329	36	156	156	CD
cord-012045-1cqqj84n	329	37	]	]	-RRB-
cord-012045-1cqqj84n	329	38	.	.	.
cord-012045-1cqqj84n	330	1	The	the	DT
cord-012045-1cqqj84n	330	2	above	above	JJ
cord-012045-1cqqj84n	330	3	findings	finding	NNS
cord-012045-1cqqj84n	330	4	present	present	JJ
cord-012045-1cqqj84n	330	5	great	great	JJ
cord-012045-1cqqj84n	330	6	interest	interest	NN
cord-012045-1cqqj84n	330	7	to	to	TO
cord-012045-1cqqj84n	330	8	explore	explore	VB
cord-012045-1cqqj84n	330	9	a	a	DT
cord-012045-1cqqj84n	330	10	DUB	dub	NN
cord-012045-1cqqj84n	330	11	-	-	HYPH
cord-012045-1cqqj84n	330	12	associated	associate	VBN
cord-012045-1cqqj84n	330	13	anti	anti	JJ
cord-012045-1cqqj84n	330	14	-	-	JJ
cord-012045-1cqqj84n	330	15	infective	infective	JJ
cord-012045-1cqqj84n	330	16	strategy	strategy	NN
cord-012045-1cqqj84n	330	17	for	for	IN
cord-012045-1cqqj84n	330	18	human	human	JJ
cord-012045-1cqqj84n	330	19	pathogen	pathogen	NN
cord-012045-1cqqj84n	330	20	invasions	invasion	NNS
cord-012045-1cqqj84n	330	21	.	.	.
cord-012045-1cqqj84n	331	1	However	however	RB
cord-012045-1cqqj84n	331	2	,	,	,
cord-012045-1cqqj84n	331	3	despite	despite	IN
cord-012045-1cqqj84n	331	4	the	the	DT
cord-012045-1cqqj84n	331	5	possibility	possibility	NN
cord-012045-1cqqj84n	331	6	of	of	IN
cord-012045-1cqqj84n	331	7	DUBs	dub	NNS
cord-012045-1cqqj84n	331	8	as	as	IN
cord-012045-1cqqj84n	331	9	drug	drug	NN
cord-012045-1cqqj84n	331	10	targets	target	NNS
cord-012045-1cqqj84n	331	11	,	,	,
cord-012045-1cqqj84n	331	12	the	the	DT
cord-012045-1cqqj84n	331	13	drug	drug	NN
cord-012045-1cqqj84n	331	14	discovery	discovery	NN
cord-012045-1cqqj84n	331	15	for	for	IN
cord-012045-1cqqj84n	331	16	ALI	ALI	NNP
cord-012045-1cqqj84n	331	17	/	/	SYM
cord-012045-1cqqj84n	331	18	ARDS	ARDS	NNP
cord-012045-1cqqj84n	331	19	is	be	VBZ
cord-012045-1cqqj84n	331	20	still	still	RB
cord-012045-1cqqj84n	331	21	challenging	challenge	VBG
cord-012045-1cqqj84n	331	22	,	,	,
cord-012045-1cqqj84n	331	23	with	with	IN
cord-012045-1cqqj84n	331	24	few	few	JJ
cord-012045-1cqqj84n	331	25	DUB	DUB	NNP
cord-012045-1cqqj84n	331	26	inhibitors	inhibitor	NNS
cord-012045-1cqqj84n	331	27	or	or	CC
cord-012045-1cqqj84n	331	28	activators	activator	NNS
cord-012045-1cqqj84n	331	29	having	have	VBG
cord-012045-1cqqj84n	331	30	been	be	VBN
cord-012045-1cqqj84n	331	31	explored	explore	VBN
cord-012045-1cqqj84n	331	32	.	.	.
cord-012045-1cqqj84n	332	1	During	during	IN
cord-012045-1cqqj84n	332	2	the	the	DT
cord-012045-1cqqj84n	332	3	past	past	JJ
cord-012045-1cqqj84n	332	4	decade	decade	NN
cord-012045-1cqqj84n	332	5	,	,	,
cord-012045-1cqqj84n	332	6	studies	study	NNS
cord-012045-1cqqj84n	332	7	began	begin	VBD
cord-012045-1cqqj84n	332	8	to	to	TO
cord-012045-1cqqj84n	332	9	dissect	dissect	VB
cord-012045-1cqqj84n	332	10	the	the	DT
cord-012045-1cqqj84n	332	11	role	role	NN
cord-012045-1cqqj84n	332	12	of	of	IN
cord-012045-1cqqj84n	332	13	DUBs	dub	NNS
cord-012045-1cqqj84n	332	14	in	in	IN
cord-012045-1cqqj84n	332	15	ALI	ALI	NNP
cord-012045-1cqqj84n	332	16	/	/	SYM
cord-012045-1cqqj84n	332	17	ARDS	ARDS	NNP
cord-012045-1cqqj84n	332	18	.	.	.
cord-012045-1cqqj84n	333	1	Increasing	increase	VBG
cord-012045-1cqqj84n	333	2	evidence	evidence	NN
cord-012045-1cqqj84n	333	3	proved	prove	VBD
cord-012045-1cqqj84n	333	4	that	that	IN
cord-012045-1cqqj84n	333	5	immune	immune	JJ
cord-012045-1cqqj84n	333	6	responses	response	NNS
cord-012045-1cqqj84n	333	7	,	,	,
cord-012045-1cqqj84n	333	8	inflammation	inflammation	NN
cord-012045-1cqqj84n	333	9	,	,	,
cord-012045-1cqqj84n	333	10	cell	cell	NN
cord-012045-1cqqj84n	333	11	death	death	NN
cord-012045-1cqqj84n	333	12	,	,	,
cord-012045-1cqqj84n	333	13	air	air	NN
cord-012045-1cqqj84n	333	14	-	-	HYPH
cord-012045-1cqqj84n	333	15	blood	blood	NN
cord-012045-1cqqj84n	333	16	barrier	barrier	NN
cord-012045-1cqqj84n	333	17	integrity	integrity	NN
cord-012045-1cqqj84n	333	18	,	,	,
cord-012045-1cqqj84n	333	19	and	and	CC
cord-012045-1cqqj84n	333	20	invasiveness	invasiveness	NN
cord-012045-1cqqj84n	333	21	of	of	IN
cord-012045-1cqqj84n	333	22	the	the	DT
cord-012045-1cqqj84n	333	23	pathogens	pathogen	NNS
cord-012045-1cqqj84n	333	24	are	be	VBP
cord-012045-1cqqj84n	333	25	fine	fine	RB
cord-012045-1cqqj84n	333	26	-	-	HYPH
cord-012045-1cqqj84n	333	27	tuned	tune	VBN
cord-012045-1cqqj84n	333	28	by	by	IN
cord-012045-1cqqj84n	333	29	DUBs	dub	NNS
cord-012045-1cqqj84n	333	30	in	in	IN
cord-012045-1cqqj84n	333	31	ALI	ALI	NNP
cord-012045-1cqqj84n	333	32	/	/	SYM
cord-012045-1cqqj84n	333	33	ARDS	ARDS	NNP
cord-012045-1cqqj84n	333	34	(	(	-LRB-
cord-012045-1cqqj84n	333	35	Figure	figure	NN
cord-012045-1cqqj84n	333	36	2	2	CD
cord-012045-1cqqj84n	333	37	)	)	-RRB-
cord-012045-1cqqj84n	333	38	.	.	.
cord-012045-1cqqj84n	334	1	Modulation	modulation	NN
cord-012045-1cqqj84n	334	2	of	of	IN
cord-012045-1cqqj84n	334	3	critical	critical	JJ
cord-012045-1cqqj84n	334	4	proteins	protein	NNS
cord-012045-1cqqj84n	334	5	via	via	IN
cord-012045-1cqqj84n	334	6	UPS	up	NNS
cord-012045-1cqqj84n	334	7	and	and	CC
cord-012045-1cqqj84n	334	8	DUBs	dub	NNS
cord-012045-1cqqj84n	334	9	plays	play	VBZ
cord-012045-1cqqj84n	334	10	a	a	DT
cord-012045-1cqqj84n	334	11	central	central	JJ
cord-012045-1cqqj84n	334	12	role	role	NN
cord-012045-1cqqj84n	334	13	in	in	IN
cord-012045-1cqqj84n	334	14	the	the	DT
cord-012045-1cqqj84n	334	15	pathogenesis	pathogenesis	NN
cord-012045-1cqqj84n	334	16	of	of	IN
cord-012045-1cqqj84n	334	17	diseases	disease	NNS
cord-012045-1cqqj84n	334	18	such	such	JJ
cord-012045-1cqqj84n	334	19	as	as	IN
cord-012045-1cqqj84n	334	20	cancer	cancer	NN
cord-012045-1cqqj84n	334	21	and	and	CC
cord-012045-1cqqj84n	334	22	autoimmune	autoimmune	JJ
cord-012045-1cqqj84n	334	23	disease	disease	NN
cord-012045-1cqqj84n	334	24	.	.	.
cord-012045-1cqqj84n	335	1	Furthermore	furthermore	RB
cord-012045-1cqqj84n	335	2	,	,	,
cord-012045-1cqqj84n	335	3	DUBs	dub	NNS
cord-012045-1cqqj84n	335	4	are	be	VBP
cord-012045-1cqqj84n	335	5	drawing	draw	VBG
cord-012045-1cqqj84n	335	6	increasing	increase	VBG
cord-012045-1cqqj84n	335	7	interest	interest	NN
cord-012045-1cqqj84n	335	8	as	as	IN
cord-012045-1cqqj84n	335	9	therapeutic	therapeutic	JJ
cord-012045-1cqqj84n	335	10	targets	target	NNS
cord-012045-1cqqj84n	335	11	against	against	IN
cord-012045-1cqqj84n	335	12	these	these	DT
cord-012045-1cqqj84n	335	13	diseases	disease	NNS
cord-012045-1cqqj84n	335	14	.	.	.
cord-012045-1cqqj84n	336	1	Our	-PRON-	PRP$
cord-012045-1cqqj84n	336	2	understanding	understanding	NN
cord-012045-1cqqj84n	336	3	of	of	IN
cord-012045-1cqqj84n	336	4	DUBs	dub	NNS
cord-012045-1cqqj84n	336	5	in	in	IN
cord-012045-1cqqj84n	336	6	ALI	ALI	NNP
cord-012045-1cqqj84n	336	7	/	/	SYM
cord-012045-1cqqj84n	336	8	ARDS	ARDS	NNP
cord-012045-1cqqj84n	336	9	is	be	VBZ
cord-012045-1cqqj84n	336	10	limited	limit	VBN
cord-012045-1cqqj84n	336	11	,	,	,
cord-012045-1cqqj84n	336	12	and	and	CC
cord-012045-1cqqj84n	336	13	the	the	DT
cord-012045-1cqqj84n	336	14	specific	specific	JJ
cord-012045-1cqqj84n	336	15	role	role	NN
cord-012045-1cqqj84n	336	16	of	of	IN
cord-012045-1cqqj84n	336	17	DUBs	dub	NNS
cord-012045-1cqqj84n	336	18	remains	remain	VBZ
cord-012045-1cqqj84n	336	19	largely	largely	RB
cord-012045-1cqqj84n	336	20	unknown	unknown	JJ
cord-012045-1cqqj84n	336	21	.	.	.
cord-012045-1cqqj84n	337	1	Particularly	particularly	RB
cord-012045-1cqqj84n	337	2	,	,	,
cord-012045-1cqqj84n	337	3	the	the	DT
cord-012045-1cqqj84n	337	4	global	global	JJ
cord-012045-1cqqj84n	337	5	outbreak	outbreak	NN
cord-012045-1cqqj84n	337	6	of	of	IN
cord-012045-1cqqj84n	337	7	COVID-19	COVID-19	NNP
cord-012045-1cqqj84n	337	8	has	have	VBZ
cord-012045-1cqqj84n	337	9	raised	raise	VBN
cord-012045-1cqqj84n	337	10	the	the	DT
cord-012045-1cqqj84n	337	11	demand	demand	NN
cord-012045-1cqqj84n	337	12	for	for	IN
cord-012045-1cqqj84n	337	13	research	research	NN
cord-012045-1cqqj84n	337	14	on	on	IN
cord-012045-1cqqj84n	337	15	the	the	DT
cord-012045-1cqqj84n	337	16	pathological	pathological	JJ
cord-012045-1cqqj84n	337	17	mechanisms	mechanism	NNS
cord-012045-1cqqj84n	337	18	of	of	IN
cord-012045-1cqqj84n	337	19	ALI	ALI	NNP
cord-012045-1cqqj84n	337	20	/	/	SYM
cord-012045-1cqqj84n	337	21	ARDS	ARDS	NNP
cord-012045-1cqqj84n	337	22	.	.	.
cord-012045-1cqqj84n	338	1	Discovery	discovery	NN
cord-012045-1cqqj84n	338	2	of	of	IN
cord-012045-1cqqj84n	338	3	the	the	DT
cord-012045-1cqqj84n	338	4	role	role	NN
cord-012045-1cqqj84n	338	5	of	of	IN
cord-012045-1cqqj84n	338	6	DUBs	dub	NNS
cord-012045-1cqqj84n	338	7	in	in	IN
cord-012045-1cqqj84n	338	8	ALI	ALI	NNP
cord-012045-1cqqj84n	338	9	/	/	SYM
cord-012045-1cqqj84n	338	10	ARDS	ARDS	NNP
cord-012045-1cqqj84n	338	11	might	may	MD
cord-012045-1cqqj84n	338	12	bring	bring	VB
cord-012045-1cqqj84n	338	13	valuable	valuable	JJ
cord-012045-1cqqj84n	338	14	information	information	NN
cord-012045-1cqqj84n	338	15	on	on	IN
cord-012045-1cqqj84n	338	16	the	the	DT
cord-012045-1cqqj84n	338	17	pathogenesis	pathogenesis	NN
cord-012045-1cqqj84n	338	18	of	of	IN
cord-012045-1cqqj84n	338	19	the	the	DT
cord-012045-1cqqj84n	338	20	illness	illness	NN
cord-012045-1cqqj84n	338	21	and	and	CC
cord-012045-1cqqj84n	338	22	thereafter	thereafter	RB
cord-012045-1cqqj84n	338	23	drug	drug	NN
cord-012045-1cqqj84n	338	24	discovery	discovery	NN
cord-012045-1cqqj84n	338	25	.	.	.
cord-012045-1cqqj84n	339	1	The	the	DT
cord-012045-1cqqj84n	339	2	diversified	diversified	JJ
cord-012045-1cqqj84n	339	3	microbial	microbial	JJ
cord-012045-1cqqj84n	339	4	pathogens	pathogen	NNS
cord-012045-1cqqj84n	339	5	may	may	MD
cord-012045-1cqqj84n	339	6	cause	cause	VB
cord-012045-1cqqj84n	339	7	ALI	ALI	NNP
cord-012045-1cqqj84n	339	8	/	/	SYM
cord-012045-1cqqj84n	339	9	ARDS	ARDS	NNP
cord-012045-1cqqj84n	339	10	via	via	IN
cord-012045-1cqqj84n	339	11	distinct	distinct	JJ
cord-012045-1cqqj84n	339	12	molecular	molecular	JJ
cord-012045-1cqqj84n	339	13	mechanisms	mechanism	NNS
cord-012045-1cqqj84n	339	14	,	,	,
cord-012045-1cqqj84n	339	15	which	which	WDT
cord-012045-1cqqj84n	339	16	increase	increase	VBP
cord-012045-1cqqj84n	339	17	the	the	DT
cord-012045-1cqqj84n	339	18	complexity	complexity	NN
cord-012045-1cqqj84n	339	19	of	of	IN
cord-012045-1cqqj84n	339	20	the	the	DT
cord-012045-1cqqj84n	339	21	whole	whole	JJ
cord-012045-1cqqj84n	339	22	picture	picture	NN
cord-012045-1cqqj84n	339	23	that	that	WDT
cord-012045-1cqqj84n	339	24	we	-PRON-	PRP
cord-012045-1cqqj84n	339	25	are	be	VBP
cord-012045-1cqqj84n	339	26	attempting	attempt	VBG
cord-012045-1cqqj84n	339	27	to	to	TO
cord-012045-1cqqj84n	339	28	figure	figure	VB
cord-012045-1cqqj84n	339	29	out	out	RP
cord-012045-1cqqj84n	339	30	.	.	.
cord-012045-1cqqj84n	340	1	On	on	IN
cord-012045-1cqqj84n	340	2	the	the	DT
cord-012045-1cqqj84n	340	3	other	other	JJ
cord-012045-1cqqj84n	340	4	hand	hand	NN
cord-012045-1cqqj84n	340	5	,	,	,
cord-012045-1cqqj84n	340	6	the	the	DT
cord-012045-1cqqj84n	340	7	current	current	JJ
cord-012045-1cqqj84n	340	8	studies	study	NNS
cord-012045-1cqqj84n	340	9	are	be	VBP
cord-012045-1cqqj84n	340	10	mostly	mostly	RB
cord-012045-1cqqj84n	340	11	focused	focused	JJ
cord-012045-1cqqj84n	340	12	on	on	IN
cord-012045-1cqqj84n	340	13	the	the	DT
cord-012045-1cqqj84n	340	14	function	function	NN
cord-012045-1cqqj84n	340	15	of	of	IN
cord-012045-1cqqj84n	340	16	DUBs	dub	NNS
cord-012045-1cqqj84n	340	17	on	on	IN
cord-012045-1cqqj84n	340	18	the	the	DT
cord-012045-1cqqj84n	340	19	regulation	regulation	NN
cord-012045-1cqqj84n	340	20	of	of	IN
cord-012045-1cqqj84n	340	21	protein	protein	NN
cord-012045-1cqqj84n	340	22	degradation	degradation	NN
cord-012045-1cqqj84n	340	23	and	and	CC
cord-012045-1cqqj84n	340	24	stability	stability	NN
cord-012045-1cqqj84n	340	25	.	.	.
cord-012045-1cqqj84n	341	1	The	the	DT
cord-012045-1cqqj84n	341	2	functions	function	NNS
cord-012045-1cqqj84n	341	3	of	of	IN
cord-012045-1cqqj84n	341	4	DUBs	dub	NNS
cord-012045-1cqqj84n	341	5	other	other	JJ
cord-012045-1cqqj84n	341	6	than	than	IN
cord-012045-1cqqj84n	341	7	protein	protein	NN
cord-012045-1cqqj84n	341	8	stability	stability	NN
cord-012045-1cqqj84n	341	9	are	be	VBP
cord-012045-1cqqj84n	341	10	yet	yet	RB
cord-012045-1cqqj84n	341	11	to	to	TO
cord-012045-1cqqj84n	341	12	be	be	VB
cord-012045-1cqqj84n	341	13	studied	study	VBN
cord-012045-1cqqj84n	341	14	in	in	IN
cord-012045-1cqqj84n	341	15	the	the	DT
cord-012045-1cqqj84n	341	16	setting	setting	NN
cord-012045-1cqqj84n	341	17	of	of	IN
cord-012045-1cqqj84n	341	18	ALI	ALI	NNP
cord-012045-1cqqj84n	341	19	/	/	SYM
cord-012045-1cqqj84n	341	20	ARDS.As	ARDS.As	NNP
cord-012045-1cqqj84n	341	21	a	a	DT
cord-012045-1cqqj84n	341	22	post	post	JJ
cord-012045-1cqqj84n	341	23	-	-	JJ
cord-012045-1cqqj84n	341	24	translational	translational	JJ
cord-012045-1cqqj84n	341	25	modification	modification	NN
cord-012045-1cqqj84n	341	26	,	,	,
cord-012045-1cqqj84n	341	27	ubiquitinated	ubiquitinated	JJ
cord-012045-1cqqj84n	341	28	proteins	protein	NNS
cord-012045-1cqqj84n	341	29	may	may	MD
cord-012045-1cqqj84n	341	30	exert	exert	VB
cord-012045-1cqqj84n	341	31	a	a	DT
cord-012045-1cqqj84n	341	32	range	range	NN
cord-012045-1cqqj84n	341	33	of	of	IN
cord-012045-1cqqj84n	341	34	functions	function	NNS
cord-012045-1cqqj84n	341	35	in	in	IN
cord-012045-1cqqj84n	341	36	life	life	NN
cord-012045-1cqqj84n	341	37	processes	process	NNS
cord-012045-1cqqj84n	341	38	and	and	CC
cord-012045-1cqqj84n	341	39	in	in	IN
cord-012045-1cqqj84n	341	40	the	the	DT
cord-012045-1cqqj84n	341	41	pathogenesis	pathogenesis	NN
cord-012045-1cqqj84n	341	42	of	of	IN
cord-012045-1cqqj84n	341	43	ALI	ALI	NNP
cord-012045-1cqqj84n	341	44	/	/	SYM
cord-012045-1cqqj84n	341	45	ARDS	ARDS	NNP
cord-012045-1cqqj84n	341	46	,	,	,
cord-012045-1cqqj84n	341	47	such	such	JJ
cord-012045-1cqqj84n	341	48	as	as	IN
cord-012045-1cqqj84n	341	49	signaling	signal	VBG
cord-012045-1cqqj84n	341	50	transduced	transduce	VBN
cord-012045-1cqqj84n	341	51	via	via	IN
cord-012045-1cqqj84n	341	52	ubiquitinated	ubiquitinated	JJ
cord-012045-1cqqj84n	341	53	protein	protein	NN
cord-012045-1cqqj84n	341	54	.	.	.
cord-012045-1cqqj84n	342	1	It	-PRON-	PRP
cord-012045-1cqqj84n	342	2	is	be	VBZ
cord-012045-1cqqj84n	342	3	hoped	hope	VBN
cord-012045-1cqqj84n	342	4	that	that	IN
cord-012045-1cqqj84n	342	5	more	more	JJR
cord-012045-1cqqj84n	342	6	data	datum	NNS
cord-012045-1cqqj84n	342	7	on	on	IN
cord-012045-1cqqj84n	342	8	DUBs	dub	NNS
cord-012045-1cqqj84n	342	9	might	may	MD
cord-012045-1cqqj84n	342	10	lead	lead	VB
cord-012045-1cqqj84n	342	11	to	to	IN
cord-012045-1cqqj84n	342	12	identification	identification	NN
cord-012045-1cqqj84n	342	13	of	of	IN
cord-012045-1cqqj84n	342	14	novel	novel	JJ
cord-012045-1cqqj84n	342	15	molecular	molecular	JJ
cord-012045-1cqqj84n	342	16	mechanisms	mechanism	NNS
cord-012045-1cqqj84n	342	17	in	in	IN
cord-012045-1cqqj84n	342	18	ALI	ALI	NNP
cord-012045-1cqqj84n	342	19	/	/	SYM
cord-012045-1cqqj84n	342	20	ARDS	ARDS	NNP
cord-012045-1cqqj84n	342	21	,	,	,
cord-012045-1cqqj84n	342	22	thus	thus	RB
cord-012045-1cqqj84n	342	23	allowing	allow	VBG
cord-012045-1cqqj84n	342	24	the	the	DT
cord-012045-1cqqj84n	342	25	development	development	NN
cord-012045-1cqqj84n	342	26	of	of	IN
cord-012045-1cqqj84n	342	27	specific	specific	JJ
cord-012045-1cqqj84n	342	28	DUB	DUB	NNP
cord-012045-1cqqj84n	342	29	inhibitors	inhibitor	NNS
cord-012045-1cqqj84n	342	30	/	/	SYM
cord-012045-1cqqj84n	342	31	agonists	agonist	NNS
cord-012045-1cqqj84n	342	32	for	for	IN
cord-012045-1cqqj84n	342	33	the	the	DT
cord-012045-1cqqj84n	342	34	treatment	treatment	NN
cord-012045-1cqqj84n	342	35	of	of	IN
cord-012045-1cqqj84n	342	36	this	this	DT
cord-012045-1cqqj84n	342	37	acute	acute	JJ
cord-012045-1cqqj84n	342	38	and	and	CC
cord-012045-1cqqj84n	342	39	severe	severe	JJ
cord-012045-1cqqj84n	342	40	respiratory	respiratory	JJ
cord-012045-1cqqj84n	342	41	illness	illness	NN
cord-012045-1cqqj84n	342	42	.	.	.
cord-012045-1cqqj84n	343	1	Funding	funding	NN
cord-012045-1cqqj84n	343	2	:	:	:
cord-012045-1cqqj84n	344	1	This	this	DT
cord-012045-1cqqj84n	344	2	work	work	NN
cord-012045-1cqqj84n	344	3	is	be	VBZ
cord-012045-1cqqj84n	344	4	supported	support	VBN
cord-012045-1cqqj84n	344	5	with	with	IN
cord-012045-1cqqj84n	344	6	R01	R01	NNP
cord-012045-1cqqj84n	344	7	grants	grant	NNS
cord-012045-1cqqj84n	344	8	(	(	-LRB-
cord-012045-1cqqj84n	344	9	HL125435	hl125435	NN
cord-012045-1cqqj84n	344	10	and	and	CC
cord-012045-1cqqj84n	344	11	HL142997	HL142997	NNP
cord-012045-1cqqj84n	344	12	)	)	-RRB-
cord-012045-1cqqj84n	344	13	from	from	IN
cord-012045-1cqqj84n	344	14	National	National	NNP
cord-012045-1cqqj84n	344	15	Institute	Institute	NNP
cord-012045-1cqqj84n	344	16	of	of	IN
cord-012045-1cqqj84n	344	17	Health	Health	NNP
cord-012045-1cqqj84n	344	18	at	at	IN
cord-012045-1cqqj84n	344	19	The	the	DT
cord-012045-1cqqj84n	344	20	United	United	NNP
cord-012045-1cqqj84n	344	21	States	States	NNP
cord-012045-1cqqj84n	344	22	to	to	IN
cord-012045-1cqqj84n	344	23	C.Z.	C.Z.	NNP
cord-012045-1cqqj84n	345	1	The	the	DT
cord-012045-1cqqj84n	345	2	authors	author	NNS
cord-012045-1cqqj84n	345	3	declare	declare	VBP
cord-012045-1cqqj84n	345	4	no	no	DT
cord-012045-1cqqj84n	345	5	conflict	conflict	NN
cord-012045-1cqqj84n	345	6	of	of	IN
cord-012045-1cqqj84n	345	7	interest	interest	NN
cord-012045-1cqqj84n	345	8	.	.	.
cord-012045-1cqqj84n	346	1	The	the	DT
cord-012045-1cqqj84n	346	2	funders	funder	NNS
cord-012045-1cqqj84n	346	3	had	have	VBD
cord-012045-1cqqj84n	346	4	no	no	DT
cord-012045-1cqqj84n	346	5	role	role	NN
cord-012045-1cqqj84n	346	6	in	in	IN
cord-012045-1cqqj84n	346	7	the	the	DT
cord-012045-1cqqj84n	346	8	design	design	NN
cord-012045-1cqqj84n	346	9	of	of	IN
cord-012045-1cqqj84n	346	10	the	the	DT
cord-012045-1cqqj84n	346	11	study	study	NN
cord-012045-1cqqj84n	346	12	;	;	:
cord-012045-1cqqj84n	346	13	in	in	IN
cord-012045-1cqqj84n	346	14	the	the	DT
cord-012045-1cqqj84n	346	15	collection	collection	NN
cord-012045-1cqqj84n	346	16	,	,	,
cord-012045-1cqqj84n	346	17	analyses	analysis	NNS
cord-012045-1cqqj84n	346	18	,	,	,
cord-012045-1cqqj84n	346	19	or	or	CC
cord-012045-1cqqj84n	346	20	interpretation	interpretation	NN
cord-012045-1cqqj84n	346	21	of	of	IN
cord-012045-1cqqj84n	346	22	data	datum	NNS
cord-012045-1cqqj84n	346	23	;	;	:
cord-012045-1cqqj84n	346	24	in	in	IN
cord-012045-1cqqj84n	346	25	the	the	DT
cord-012045-1cqqj84n	346	26	writing	writing	NN
cord-012045-1cqqj84n	346	27	of	of	IN
cord-012045-1cqqj84n	346	28	the	the	DT
cord-012045-1cqqj84n	346	29	manuscript	manuscript	NN
cord-012045-1cqqj84n	346	30	,	,	,
cord-012045-1cqqj84n	346	31	or	or	CC
cord-012045-1cqqj84n	346	32	in	in	IN
cord-012045-1cqqj84n	346	33	the	the	DT
cord-012045-1cqqj84n	346	34	decision	decision	NN
cord-012045-1cqqj84n	346	35	to	to	TO
cord-012045-1cqqj84n	346	36	publish	publish	VB
cord-012045-1cqqj84n	346	37	the	the	DT
cord-012045-1cqqj84n	346	38	results	result	NNS
cord-012045-1cqqj84n	346	39	.	.	.
cord-012045-1cqqj84n	347	1	Funding	funding	NN
cord-012045-1cqqj84n	347	2	:	:	:
cord-012045-1cqqj84n	348	1	This	this	DT
cord-012045-1cqqj84n	348	2	work	work	NN
cord-012045-1cqqj84n	348	3	is	be	VBZ
cord-012045-1cqqj84n	348	4	supported	support	VBN
cord-012045-1cqqj84n	348	5	with	with	IN
cord-012045-1cqqj84n	348	6	R01	R01	NNP
cord-012045-1cqqj84n	348	7	grants	grant	NNS
cord-012045-1cqqj84n	348	8	(	(	-LRB-
cord-012045-1cqqj84n	348	9	HL125435	hl125435	NN
cord-012045-1cqqj84n	348	10	and	and	CC
cord-012045-1cqqj84n	348	11	HL142997	HL142997	NNP
cord-012045-1cqqj84n	348	12	)	)	-RRB-
cord-012045-1cqqj84n	348	13	from	from	IN
cord-012045-1cqqj84n	348	14	National	National	NNP
cord-012045-1cqqj84n	348	15	Institute	Institute	NNP
cord-012045-1cqqj84n	348	16	of	of	IN
cord-012045-1cqqj84n	348	17	Health	Health	NNP
cord-012045-1cqqj84n	348	18	at	at	IN
cord-012045-1cqqj84n	348	19	The	the	DT
cord-012045-1cqqj84n	348	20	United	United	NNP
cord-012045-1cqqj84n	348	21	States	States	NNP
cord-012045-1cqqj84n	348	22	to	to	IN
cord-012045-1cqqj84n	348	23	C.Z.	C.Z.	NNP
cord-012045-1cqqj84n	349	1	The	the	DT
cord-012045-1cqqj84n	349	2	authors	author	NNS
cord-012045-1cqqj84n	349	3	declare	declare	VBP
cord-012045-1cqqj84n	349	4	no	no	DT
cord-012045-1cqqj84n	349	5	conflict	conflict	NN
cord-012045-1cqqj84n	349	6	of	of	IN
cord-012045-1cqqj84n	349	7	interest	interest	NN
cord-012045-1cqqj84n	349	8	.	.	.
cord-012045-1cqqj84n	350	1	The	the	DT
cord-012045-1cqqj84n	350	2	funders	funder	NNS
cord-012045-1cqqj84n	350	3	had	have	VBD
cord-012045-1cqqj84n	350	4	no	no	DT
cord-012045-1cqqj84n	350	5	role	role	NN
cord-012045-1cqqj84n	350	6	in	in	IN
cord-012045-1cqqj84n	350	7	the	the	DT
cord-012045-1cqqj84n	350	8	design	design	NN
cord-012045-1cqqj84n	350	9	of	of	IN
cord-012045-1cqqj84n	350	10	the	the	DT
cord-012045-1cqqj84n	350	11	study	study	NN
cord-012045-1cqqj84n	350	12	;	;	:
cord-012045-1cqqj84n	350	13	in	in	IN
cord-012045-1cqqj84n	350	14	the	the	DT
cord-012045-1cqqj84n	350	15	collection	collection	NN
cord-012045-1cqqj84n	350	16	,	,	,
cord-012045-1cqqj84n	350	17	analyses	analysis	NNS
cord-012045-1cqqj84n	350	18	,	,	,
cord-012045-1cqqj84n	350	19	or	or	CC
cord-012045-1cqqj84n	350	20	interpretation	interpretation	NN
cord-012045-1cqqj84n	350	21	of	of	IN
cord-012045-1cqqj84n	350	22	data	datum	NNS
cord-012045-1cqqj84n	350	23	;	;	:
cord-012045-1cqqj84n	350	24	in	in	IN
cord-012045-1cqqj84n	350	25	the	the	DT
cord-012045-1cqqj84n	350	26	writing	writing	NN
cord-012045-1cqqj84n	350	27	of	of	IN
cord-012045-1cqqj84n	350	28	the	the	DT
cord-012045-1cqqj84n	350	29	manuscript	manuscript	NN
cord-012045-1cqqj84n	350	30	,	,	,
cord-012045-1cqqj84n	350	31	or	or	CC
cord-012045-1cqqj84n	350	32	in	in	IN
cord-012045-1cqqj84n	350	33	the	the	DT
cord-012045-1cqqj84n	350	34	decision	decision	NN
cord-012045-1cqqj84n	350	35	to	to	TO
cord-012045-1cqqj84n	350	36	publish	publish	VB
cord-012045-1cqqj84n	350	37	the	the	DT
cord-012045-1cqqj84n	350	38	results	result	NNS
cord-012045-1cqqj84n	350	39	.	.	.
cord-012045-1cqqj84n	351	1	Proteasome	Proteasome	NNP
cord-012045-1cqqj84n	351	2	non	non	JJ
cord-012045-1cqqj84n	351	3	-	-	JJ
cord-012045-1cqqj84n	351	4	ATPase	atpase	JJ
cord-012045-1cqqj84n	351	5	regulatory	regulatory	JJ
cord-012045-1cqqj84n	351	6	subunit	subunit	NN
cord-012045-1cqqj84n	351	7	14	14	CD
cord-012045-1cqqj84n	351	8	PRPF8	PRPF8	NNP
cord-012045-1cqqj84n	351	9	Pre	Pre	NNP
cord-012045-1cqqj84n	351	10	-	-	JJ
cord-012045-1cqqj84n	351	11	mRNA	mrna	NN
cord-012045-1cqqj84n	351	12	-	-	HYPH
cord-012045-1cqqj84n	351	13	processing	processing	NN
cord-012045-1cqqj84n	351	14	-	-	HYPH
cord-012045-1cqqj84n	351	15	splicing	splicing	NN
cord-012045-1cqqj84n	351	16	factor	factor	NN
cord-012045-1cqqj84n	352	1	8	8	CD
cord-012045-1cqqj84n	352	2	PSMD7	psmd7	NN
cord-012045-1cqqj84n	353	1	Proteasome	Proteasome	NNP
cord-012045-1cqqj84n	353	2	non	non	JJ
cord-012045-1cqqj84n	353	3	-	-	JJ
cord-012045-1cqqj84n	353	4	ATPase	atpase	JJ
cord-012045-1cqqj84n	353	5	regulatory	regulatory	JJ
cord-012045-1cqqj84n	353	6	subunit	subunit	NN
cord-012045-1cqqj84n	353	7	7	7	CD
cord-012045-1cqqj84n	353	8	RIG-1	RIG-1	NNP
cord-012045-1cqqj84n	354	1	Retinoic	retinoic	JJ
cord-012045-1cqqj84n	354	2	acid	acid	NN
cord-012045-1cqqj84n	354	3	-	-	HYPH
cord-012045-1cqqj84n	354	4	inducible	inducible	JJ
cord-012045-1cqqj84n	354	5	gene	gene	NN
cord-012045-1cqqj84n	355	1	I	-PRON-	PRP
cord-012045-1cqqj84n	355	2	RIPK1	ripk1	RB
cord-012045-1cqqj84n	355	3	Receptor	receptor	NN
cord-012045-1cqqj84n	355	4	-	-	HYPH
cord-012045-1cqqj84n	355	5	interacting	interact	VBG
cord-012045-1cqqj84n	355	6	protein	protein	NN
cord-012045-1cqqj84n	355	7	kinase	kinase	NN
cord-012045-1cqqj84n	355	8	1	1	CD
cord-012045-1cqqj84n	355	9	SARS	SARS	NNP
cord-012045-1cqqj84n	355	10	-	-	HYPH
cord-012045-1cqqj84n	355	11	CoV-2	CoV-2	NNP
cord-012045-1cqqj84n	355	12	Severe	severe	JJ
cord-012045-1cqqj84n	355	13	acute	acute	JJ
cord-012045-1cqqj84n	355	14	respiratory	respiratory	JJ
cord-012045-1cqqj84n	355	15	syndrome	syndrome	NN
cord-012045-1cqqj84n	355	16	coronavirus	coronavirus	NN
cord-012045-1cqqj84n	356	1	2	2	LS
cord-012045-1cqqj84n	356	2	STAMBP	STAMBP	NNP
cord-012045-1cqqj84n	356	3	STAM	stam	NN
cord-012045-1cqqj84n	356	4	-	-	HYPH
cord-012045-1cqqj84n	356	5	binding	bind	VBG
cord-012045-1cqqj84n	356	6	protein	protein	NN
cord-012045-1cqqj84n	356	7	STING	STING	NNP
cord-012045-1cqqj84n	356	8	Stimulator	Stimulator	NNP
cord-012045-1cqqj84n	356	9	of	of	IN
cord-012045-1cqqj84n	356	10	interferon	interferon	NN
cord-012045-1cqqj84n	357	1	TAK1	TAK1	NNP
cord-012045-1cqqj84n	357	2	TGF	TGF	NNP
cord-012045-1cqqj84n	357	3	-	-	HYPH
cord-012045-1cqqj84n	357	4	β	β	NN
cord-012045-1cqqj84n	357	5	-	-	HYPH
cord-012045-1cqqj84n	357	6	activated	activate	VBN
cord-012045-1cqqj84n	357	7	kinase	kinase	NN
cord-012045-1cqqj84n	358	1	1	1	LS
cord-012045-1cqqj84n	358	2	TGFβ-1	tgfβ-1	NN
cord-012045-1cqqj84n	358	3	Transforming	transform	VBG
cord-012045-1cqqj84n	358	4	growth	growth	NN
cord-012045-1cqqj84n	358	5	factor	factor	NN
cord-012045-1cqqj84n	358	6	β-1	β-1	NNP
cord-012045-1cqqj84n	359	1	TRIF	TRIF	NNP
cord-012045-1cqqj84n	359	2	TIR	TIR	NNP
cord-012045-1cqqj84n	359	3	domain	domain	NN
cord-012045-1cqqj84n	359	4	-	-	HYPH
cord-012045-1cqqj84n	359	5	containing	contain	VBG
cord-012045-1cqqj84n	359	6	adaptor	adaptor	NN
cord-012045-1cqqj84n	359	7	inducing	induce	VBG
cord-012045-1cqqj84n	359	8	interferon	interferon	NN
cord-012045-1cqqj84n	359	9	-	-	HYPH
cord-012045-1cqqj84n	359	10	β	β	NNP
cord-012045-1cqqj84n	359	11	TNF	TNF	NNP
cord-012045-1cqqj84n	359	12	-	-	HYPH
cord-012045-1cqqj84n	359	13	α	α	NNP
cord-012045-1cqqj84n	359	14	Tumor	tumor	NN
cord-012045-1cqqj84n	359	15	necrosis	necrosis	NN
cord-012045-1cqqj84n	359	16	factor	factor	NN
cord-012045-1cqqj84n	359	17	-	-	HYPH
cord-012045-1cqqj84n	359	18	α	α	NN
cord-012045-1cqqj84n	359	19	TRAF	TRAF	NNP
cord-012045-1cqqj84n	359	20	Tumor	Tumor	NNP
cord-012045-1cqqj84n	359	21	necrosis	necrosis	NN
cord-012045-1cqqj84n	359	22	factor	factor	NN
cord-012045-1cqqj84n	359	23	receptor	receptor	NN
cord-012045-1cqqj84n	359	24	-	-	HYPH
cord-012045-1cqqj84n	359	25	associated	associate	VBN
cord-012045-1cqqj84n	359	26	factor	factor	NN
cord-012045-1cqqj84n	359	27	UBA	UBA	NNP
cord-012045-1cqqj84n	359	28	Ub	Ub	NNP
cord-012045-1cqqj84n	359	29	-	-	HYPH
cord-012045-1cqqj84n	359	30	activating	activate	VBG
cord-012045-1cqqj84n	359	31	enzymes	enzyme	NNS
cord-012045-1cqqj84n	359	32	UBC	UBC	NNP
cord-012045-1cqqj84n	359	33	Ub	Ub	NNP
cord-012045-1cqqj84n	359	34	-	-	HYPH
cord-012045-1cqqj84n	359	35	conjugating	conjugate	VBG
cord-012045-1cqqj84n	359	36	enzymes	enzyme	NNS
cord-012045-1cqqj84n	359	37	UCHs	uch	NNS
cord-012045-1cqqj84n	359	38	Ubiquitin	Ubiquitin	NNP
cord-012045-1cqqj84n	359	39	carboxy	carboxy	JJ
cord-012045-1cqqj84n	359	40	-	-	HYPH
cord-012045-1cqqj84n	359	41	terminal	terminal	NN
cord-012045-1cqqj84n	359	42	hydrolases	hydrolase	NNS
cord-012045-1cqqj84n	359	43	USPs	USPs	NNP
cord-012045-1cqqj84n	359	44	Ubiquitin	Ubiquitin	NNP
cord-012045-1cqqj84n	359	45	-	-	HYPH
cord-012045-1cqqj84n	359	46	specific	specific	JJ
cord-012045-1cqqj84n	359	47	proteases	protease	NNS
cord-012045-1cqqj84n	360	1	The	the	DT
cord-012045-1cqqj84n	360	2	acute	acute	JJ
cord-012045-1cqqj84n	360	3	respiratory	respiratory	JJ
cord-012045-1cqqj84n	360	4	distress	distress	NN
cord-012045-1cqqj84n	360	5	syndrome	syndrome	NN
cord-012045-1cqqj84n	360	6	:	:	:
cord-012045-1cqqj84n	361	1	From	from	IN
cord-012045-1cqqj84n	361	2	mechanism	mechanism	NN
cord-012045-1cqqj84n	361	3	to	to	TO
cord-012045-1cqqj84n	361	4	translation	translation	VB
cord-012045-1cqqj84n	361	5	Acute	acute	JJ
cord-012045-1cqqj84n	361	6	respiratory	respiratory	JJ
cord-012045-1cqqj84n	361	7	distress	distress	NN
cord-012045-1cqqj84n	361	8	syndrome	syndrome	NN
cord-012045-1cqqj84n	361	9	:	:	:
cord-012045-1cqqj84n	362	1	The	the	DT
cord-012045-1cqqj84n	362	2	Berlin	Berlin	NNP
cord-012045-1cqqj84n	362	3	Definition	Definition	NNP
cord-012045-1cqqj84n	363	1	The	the	DT
cord-012045-1cqqj84n	363	2	acute	acute	JJ
cord-012045-1cqqj84n	363	3	respiratory	respiratory	JJ
cord-012045-1cqqj84n	363	4	distress	distress	NN
cord-012045-1cqqj84n	363	5	syndrome	syndrome	NN
cord-012045-1cqqj84n	363	6	in	in	IN
cord-012045-1cqqj84n	363	7	2013	2013	CD
cord-012045-1cqqj84n	363	8	Acute	acute	JJ
cord-012045-1cqqj84n	363	9	respiratory	respiratory	JJ
cord-012045-1cqqj84n	363	10	distress	distress	NN
cord-012045-1cqqj84n	363	11	syndrome	syndrome	NN
cord-012045-1cqqj84n	364	1	Acute	acute	JJ
cord-012045-1cqqj84n	364	2	respiratory	respiratory	JJ
cord-012045-1cqqj84n	364	3	distress	distress	NN
cord-012045-1cqqj84n	364	4	syndrome	syndrome	NN
cord-012045-1cqqj84n	365	1	Novel	novel	JJ
cord-012045-1cqqj84n	365	2	concepts	concept	NNS
cord-012045-1cqqj84n	365	3	of	of	IN
cord-012045-1cqqj84n	365	4	acute	acute	JJ
cord-012045-1cqqj84n	365	5	lung	lung	NN
cord-012045-1cqqj84n	365	6	injury	injury	NN
cord-012045-1cqqj84n	365	7	and	and	CC
cord-012045-1cqqj84n	365	8	alveolar	alveolar	NN
cord-012045-1cqqj84n	365	9	-	-	HYPH
cord-012045-1cqqj84n	365	10	capillary	capillary	JJ
cord-012045-1cqqj84n	365	11	barrier	barrier	NN
cord-012045-1cqqj84n	365	12	dysfunction	dysfunction	NN
cord-012045-1cqqj84n	365	13	Mechanisms	Mechanisms	NNPS
cord-012045-1cqqj84n	365	14	of	of	IN
cord-012045-1cqqj84n	365	15	pulmonary	pulmonary	JJ
cord-012045-1cqqj84n	365	16	edema	edema	NN
cord-012045-1cqqj84n	365	17	clearance	clearance	NN
cord-012045-1cqqj84n	365	18	during	during	IN
cord-012045-1cqqj84n	365	19	acute	acute	JJ
cord-012045-1cqqj84n	365	20	hypoxemic	hypoxemic	JJ
cord-012045-1cqqj84n	365	21	respiratory	respiratory	JJ
cord-012045-1cqqj84n	365	22	failure	failure	NN
cord-012045-1cqqj84n	365	23	:	:	:
cord-012045-1cqqj84n	365	24	Role	role	NN
cord-012045-1cqqj84n	365	25	of	of	IN
cord-012045-1cqqj84n	365	26	the	the	DT
cord-012045-1cqqj84n	365	27	Na	Na	NNP
cord-012045-1cqqj84n	365	28	,	,	,
cord-012045-1cqqj84n	365	29	K	K	NNP
cord-012045-1cqqj84n	365	30	-	-	HYPH
cord-012045-1cqqj84n	365	31	ATPase	ATPase	NNP
cord-012045-1cqqj84n	365	32	Healthcare	Healthcare	NNP
cord-012045-1cqqj84n	365	33	disparities	disparity	NNS
cord-012045-1cqqj84n	365	34	in	in	IN
cord-012045-1cqqj84n	365	35	patients	patient	NNS
cord-012045-1cqqj84n	365	36	with	with	IN
cord-012045-1cqqj84n	365	37	acute	acute	JJ
cord-012045-1cqqj84n	365	38	respiratory	respiratory	JJ
cord-012045-1cqqj84n	365	39	distress	distress	NN
cord-012045-1cqqj84n	365	40	syndrome	syndrome	NN
cord-012045-1cqqj84n	365	41	.	.	.
cord-012045-1cqqj84n	366	1	Toward	toward	IN
cord-012045-1cqqj84n	366	2	Equity	Equity	NNP
cord-012045-1cqqj84n	366	3	Early	early	JJ
cord-012045-1cqqj84n	366	4	local	local	JJ
cord-012045-1cqqj84n	366	5	immune	immune	JJ
cord-012045-1cqqj84n	366	6	defences	defence	NNS
cord-012045-1cqqj84n	366	7	in	in	IN
cord-012045-1cqqj84n	366	8	the	the	DT
cord-012045-1cqqj84n	366	9	respiratory	respiratory	JJ
cord-012045-1cqqj84n	366	10	tract	tract	NN
cord-012045-1cqqj84n	367	1	The	the	DT
cord-012045-1cqqj84n	367	2	pathogenesis	pathogenesis	NN
cord-012045-1cqqj84n	367	3	and	and	CC
cord-012045-1cqqj84n	367	4	treatment	treatment	NN
cord-012045-1cqqj84n	367	5	of	of	IN
cord-012045-1cqqj84n	367	6	the	the	DT
cord-012045-1cqqj84n	367	7	'	'	``
cord-012045-1cqqj84n	367	8	Cytokine	Cytokine	NNP
cord-012045-1cqqj84n	367	9	Storm	Storm	NNP
cord-012045-1cqqj84n	367	10	'	'	''
cord-012045-1cqqj84n	367	11	in	in	IN
cord-012045-1cqqj84n	367	12	COVID-19	COVID-19	NNP
cord-012045-1cqqj84n	367	13	Into	into	IN
cord-012045-1cqqj84n	367	14	the	the	DT
cord-012045-1cqqj84n	367	15	eye	eye	NN
cord-012045-1cqqj84n	367	16	of	of	IN
cord-012045-1cqqj84n	367	17	the	the	DT
cord-012045-1cqqj84n	367	18	cytokine	cytokine	NN
cord-012045-1cqqj84n	367	19	storm	storm	NN
cord-012045-1cqqj84n	367	20	.	.	.
cord-012045-1cqqj84n	368	1	Microbiol	Microbiol	NNP
cord-012045-1cqqj84n	369	1	The	the	DT
cord-012045-1cqqj84n	369	2	acute	acute	JJ
cord-012045-1cqqj84n	369	3	respiratory	respiratory	JJ
cord-012045-1cqqj84n	369	4	distress	distress	NN
cord-012045-1cqqj84n	369	5	syndrome	syndrome	NN
cord-012045-1cqqj84n	369	6	:	:	:
cord-012045-1cqqj84n	370	1	Pathogenesis	pathogenesis	NN
cord-012045-1cqqj84n	370	2	and	and	CC
cord-012045-1cqqj84n	370	3	treatment	treatment	NN
cord-012045-1cqqj84n	370	4	Pulmonary	pulmonary	JJ
cord-012045-1cqqj84n	370	5	dead	dead	JJ
cord-012045-1cqqj84n	370	6	-	-	HYPH
cord-012045-1cqqj84n	370	7	space	space	NN
cord-012045-1cqqj84n	370	8	fraction	fraction	NN
cord-012045-1cqqj84n	370	9	as	as	IN
cord-012045-1cqqj84n	370	10	a	a	DT
cord-012045-1cqqj84n	370	11	risk	risk	NN
cord-012045-1cqqj84n	370	12	factor	factor	NN
cord-012045-1cqqj84n	370	13	for	for	IN
cord-012045-1cqqj84n	370	14	death	death	NN
cord-012045-1cqqj84n	370	15	in	in	IN
cord-012045-1cqqj84n	371	1	the	the	DT
cord-012045-1cqqj84n	371	2	acute	acute	JJ
cord-012045-1cqqj84n	371	3	respiratory	respiratory	JJ
cord-012045-1cqqj84n	371	4	distress	distress	NN
cord-012045-1cqqj84n	371	5	syndrome	syndrome	NN
cord-012045-1cqqj84n	371	6	Ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	371	7	-	-	HYPH
cord-012045-1cqqj84n	371	8	proteasome	proteasome	NN
cord-012045-1cqqj84n	371	9	signaling	signaling	NN
cord-012045-1cqqj84n	371	10	in	in	IN
cord-012045-1cqqj84n	371	11	lung	lung	NN
cord-012045-1cqqj84n	371	12	injury	injury	NN
cord-012045-1cqqj84n	371	13	Ubiquitination	Ubiquitination	NNP
cord-012045-1cqqj84n	371	14	and	and	CC
cord-012045-1cqqj84n	371	15	proteolysis	proteolysis	NN
cord-012045-1cqqj84n	371	16	in	in	IN
cord-012045-1cqqj84n	371	17	acute	acute	JJ
cord-012045-1cqqj84n	371	18	lung	lung	NN
cord-012045-1cqqj84n	371	19	injury	injury	NN
cord-012045-1cqqj84n	371	20	Role	role	NN
cord-012045-1cqqj84n	371	21	of	of	IN
cord-012045-1cqqj84n	371	22	ubiquitination	ubiquitination	NN
cord-012045-1cqqj84n	371	23	in	in	IN
cord-012045-1cqqj84n	371	24	Na	Na	NNP
cord-012045-1cqqj84n	371	25	,	,	,
cord-012045-1cqqj84n	371	26	K	K	NNP
cord-012045-1cqqj84n	371	27	-	-	HYPH
cord-012045-1cqqj84n	371	28	ATPase	ATPase	NNP
cord-012045-1cqqj84n	371	29	regulation	regulation	NN
cord-012045-1cqqj84n	371	30	during	during	IN
cord-012045-1cqqj84n	371	31	lung	lung	NN
cord-012045-1cqqj84n	371	32	injury	injury	NN
cord-012045-1cqqj84n	372	1	The	the	DT
cord-012045-1cqqj84n	372	2	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	372	3	-	-	HYPH
cord-012045-1cqqj84n	372	4	proteasome	proteasome	VBN
cord-012045-1cqqj84n	372	5	proteolytic	proteolytic	JJ
cord-012045-1cqqj84n	372	6	pathway	pathway	NN
cord-012045-1cqqj84n	372	7	:	:	:
cord-012045-1cqqj84n	372	8	Destruction	destruction	NN
cord-012045-1cqqj84n	372	9	for	for	IN
cord-012045-1cqqj84n	372	10	the	the	DT
cord-012045-1cqqj84n	372	11	sake	sake	NN
cord-012045-1cqqj84n	372	12	of	of	IN
cord-012045-1cqqj84n	372	13	construction	construction	NN
cord-012045-1cqqj84n	373	1	The	the	DT
cord-012045-1cqqj84n	373	2	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	373	3	system	system	NN
cord-012045-1cqqj84n	373	4	Regulation	regulation	NN
cord-012045-1cqqj84n	373	5	of	of	IN
cord-012045-1cqqj84n	373	6	protein	protein	NN
cord-012045-1cqqj84n	373	7	stability	stability	NN
cord-012045-1cqqj84n	373	8	by	by	IN
cord-012045-1cqqj84n	373	9	GSK3	GSK3	NNP
cord-012045-1cqqj84n	373	10	mediated	mediate	VBD
cord-012045-1cqqj84n	373	11	phosphorylation	phosphorylation	NN
cord-012045-1cqqj84n	373	12	Diversity	diversity	NN
cord-012045-1cqqj84n	373	13	of	of	IN
cord-012045-1cqqj84n	373	14	degradation	degradation	NN
cord-012045-1cqqj84n	373	15	signals	signal	NNS
cord-012045-1cqqj84n	373	16	in	in	IN
cord-012045-1cqqj84n	373	17	the	the	DT
cord-012045-1cqqj84n	373	18	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	373	19	-	-	HYPH
cord-012045-1cqqj84n	373	20	proteasome	proteasome	VBN
cord-012045-1cqqj84n	373	21	system	system	NN
cord-012045-1cqqj84n	374	1	The	the	DT
cord-012045-1cqqj84n	374	2	emerging	emerge	VBG
cord-012045-1cqqj84n	374	3	role	role	NN
cord-012045-1cqqj84n	374	4	of	of	IN
cord-012045-1cqqj84n	374	5	the	the	DT
cord-012045-1cqqj84n	374	6	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	374	7	proteasome	proteasome	NN
cord-012045-1cqqj84n	374	8	in	in	IN
cord-012045-1cqqj84n	374	9	pulmonary	pulmonary	JJ
cord-012045-1cqqj84n	374	10	biology	biology	NN
cord-012045-1cqqj84n	374	11	and	and	CC
cord-012045-1cqqj84n	374	12	disease	disease	NN
cord-012045-1cqqj84n	374	13	Ubiquitination	Ubiquitination	NNP
cord-012045-1cqqj84n	374	14	and	and	CC
cord-012045-1cqqj84n	374	15	deubiquitination	deubiquitination	NN
cord-012045-1cqqj84n	374	16	:	:	:
cord-012045-1cqqj84n	375	1	Targeting	target	VBG
cord-012045-1cqqj84n	375	2	of	of	IN
cord-012045-1cqqj84n	375	3	proteins	protein	NNS
cord-012045-1cqqj84n	375	4	for	for	IN
cord-012045-1cqqj84n	375	5	degradation	degradation	NN
cord-012045-1cqqj84n	375	6	by	by	IN
cord-012045-1cqqj84n	375	7	the	the	DT
cord-012045-1cqqj84n	375	8	proteasome	proteasome	VBN
cord-012045-1cqqj84n	375	9	Deubiquitinating	deubiquitinating	NN
cord-012045-1cqqj84n	375	10	enzymes	enzyme	NNS
cord-012045-1cqqj84n	375	11	in	in	IN
cord-012045-1cqqj84n	375	12	cellular	cellular	JJ
cord-012045-1cqqj84n	375	13	signaling	signaling	NN
cord-012045-1cqqj84n	375	14	and	and	CC
cord-012045-1cqqj84n	375	15	disease	disease	NN
cord-012045-1cqqj84n	375	16	regulation	regulation	NN
cord-012045-1cqqj84n	375	17	Regulation	regulation	NN
cord-012045-1cqqj84n	375	18	and	and	CC
cord-012045-1cqqj84n	375	19	cellular	cellular	JJ
cord-012045-1cqqj84n	375	20	roles	role	NNS
cord-012045-1cqqj84n	375	21	of	of	IN
cord-012045-1cqqj84n	375	22	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	375	23	-	-	HYPH
cord-012045-1cqqj84n	375	24	specific	specific	JJ
cord-012045-1cqqj84n	375	25	deubiquitinating	deubiquitinating	NN
cord-012045-1cqqj84n	375	26	enzymes	enzyme	NNS
cord-012045-1cqqj84n	375	27	Deubiquitylases	Deubiquitylases	NNPS
cord-012045-1cqqj84n	375	28	from	from	IN
cord-012045-1cqqj84n	375	29	genes	gene	NNS
cord-012045-1cqqj84n	375	30	to	to	IN
cord-012045-1cqqj84n	375	31	organism	organism	NN
cord-012045-1cqqj84n	375	32	Breaking	break	VBG
cord-012045-1cqqj84n	375	33	the	the	DT
cord-012045-1cqqj84n	375	34	chains	chain	NNS
cord-012045-1cqqj84n	375	35	:	:	:
cord-012045-1cqqj84n	376	1	Structure	structure	NN
cord-012045-1cqqj84n	376	2	and	and	CC
cord-012045-1cqqj84n	376	3	function	function	NN
cord-012045-1cqqj84n	376	4	of	of	IN
cord-012045-1cqqj84n	376	5	the	the	DT
cord-012045-1cqqj84n	376	6	deubiquitinases	deubiquitinase	NNS
cord-012045-1cqqj84n	376	7	Mechanisms	Mechanisms	NNPS
cord-012045-1cqqj84n	376	8	of	of	IN
cord-012045-1cqqj84n	376	9	Deubiquitinase	Deubiquitinase	NNP
cord-012045-1cqqj84n	376	10	Specificity	Specificity	NNP
cord-012045-1cqqj84n	376	11	and	and	CC
cord-012045-1cqqj84n	376	12	Regulation	Regulation	NNP
cord-012045-1cqqj84n	376	13	MINDY-1	mindy-1	RB
cord-012045-1cqqj84n	376	14	Is	be	VBZ
cord-012045-1cqqj84n	376	15	a	a	DT
cord-012045-1cqqj84n	376	16	Member	Member	NNP
cord-012045-1cqqj84n	376	17	of	of	IN
cord-012045-1cqqj84n	376	18	an	an	DT
cord-012045-1cqqj84n	376	19	Evolutionarily	evolutionarily	RB
cord-012045-1cqqj84n	376	20	Conserved	conserved	JJ
cord-012045-1cqqj84n	376	21	and	and	CC
cord-012045-1cqqj84n	376	22	Structurally	structurally	RB
cord-012045-1cqqj84n	376	23	Distinct	Distinct	NNP
cord-012045-1cqqj84n	376	24	New	New	NNP
cord-012045-1cqqj84n	376	25	Family	Family	NNP
cord-012045-1cqqj84n	376	26	of	of	IN
cord-012045-1cqqj84n	376	27	Deubiquitinating	Deubiquitinating	NNP
cord-012045-1cqqj84n	376	28	Enzymes	Enzymes	NNP
cord-012045-1cqqj84n	376	29	Toll	Toll	NNP
cord-012045-1cqqj84n	376	30	-	-	HYPH
cord-012045-1cqqj84n	376	31	like	like	JJ
cord-012045-1cqqj84n	376	32	receptor	receptor	NN
cord-012045-1cqqj84n	376	33	and	and	CC
cord-012045-1cqqj84n	376	34	RIG	rig	NN
cord-012045-1cqqj84n	376	35	-	-	HYPH
cord-012045-1cqqj84n	376	36	I	-PRON-	PRP
cord-012045-1cqqj84n	376	37	-	-	HYPH
cord-012045-1cqqj84n	376	38	like	like	JJ
cord-012045-1cqqj84n	376	39	receptor	receptor	NN
cord-012045-1cqqj84n	376	40	signaling	signal	VBG
cord-012045-1cqqj84n	376	41	Innate	Innate	NNP
cord-012045-1cqqj84n	376	42	immune	immune	JJ
cord-012045-1cqqj84n	376	43	recognition	recognition	NN
cord-012045-1cqqj84n	376	44	of	of	IN
cord-012045-1cqqj84n	376	45	viral	viral	JJ
cord-012045-1cqqj84n	376	46	infection	infection	NN
cord-012045-1cqqj84n	376	47	Overexpression	overexpression	NN
cord-012045-1cqqj84n	376	48	of	of	IN
cord-012045-1cqqj84n	376	49	USP14	usp14	JJ
cord-012045-1cqqj84n	376	50	protease	protease	NN
cord-012045-1cqqj84n	376	51	reduces	reduce	VBZ
cord-012045-1cqqj84n	376	52	I	I	NNP
cord-012045-1cqqj84n	376	53	-	-	HYPH
cord-012045-1cqqj84n	376	54	kappaB	kappaB	NNP
cord-012045-1cqqj84n	376	55	protein	protein	NN
cord-012045-1cqqj84n	376	56	levels	level	NNS
cord-012045-1cqqj84n	376	57	and	and	CC
cord-012045-1cqqj84n	376	58	increases	increase	NNS
cord-012045-1cqqj84n	376	59	cytokine	cytokine	NN
cord-012045-1cqqj84n	376	60	release	release	NN
cord-012045-1cqqj84n	376	61	in	in	IN
cord-012045-1cqqj84n	376	62	lung	lung	NN
cord-012045-1cqqj84n	376	63	epithelial	epithelial	NN
cord-012045-1cqqj84n	376	64	cells	cell	NNS
cord-012045-1cqqj84n	376	65	Regulation	regulation	NN
cord-012045-1cqqj84n	376	66	of	of	IN
cord-012045-1cqqj84n	376	67	the	the	DT
cord-012045-1cqqj84n	376	68	ubiquitylation	ubiquitylation	NN
cord-012045-1cqqj84n	376	69	and	and	CC
cord-012045-1cqqj84n	376	70	deubiquitylation	deubiquitylation	NN
cord-012045-1cqqj84n	376	71	of	of	IN
cord-012045-1cqqj84n	376	72	CREB	CREB	NNP
cord-012045-1cqqj84n	376	73	-	-	HYPH
cord-012045-1cqqj84n	376	74	binding	bind	VBG
cord-012045-1cqqj84n	376	75	protein	protein	NN
cord-012045-1cqqj84n	376	76	modulates	modulate	VBZ
cord-012045-1cqqj84n	377	1	histone	histone	NN
cord-012045-1cqqj84n	377	2	acetylation	acetylation	NN
cord-012045-1cqqj84n	377	3	and	and	CC
cord-012045-1cqqj84n	377	4	lung	lung	NN
cord-012045-1cqqj84n	377	5	inflammation	inflammation	NN
cord-012045-1cqqj84n	377	6	HSCARG	HSCARG	NNP
cord-012045-1cqqj84n	377	7	downregulates	downregulate	VBZ
cord-012045-1cqqj84n	377	8	NF	NF	NNP
cord-012045-1cqqj84n	377	9	-	-	HYPH
cord-012045-1cqqj84n	377	10	kappaB	kappaB	NNP
cord-012045-1cqqj84n	377	11	signaling	signal	VBG
cord-012045-1cqqj84n	377	12	by	by	IN
cord-012045-1cqqj84n	377	13	interacting	interact	VBG
cord-012045-1cqqj84n	377	14	with	with	IN
cord-012045-1cqqj84n	377	15	USP7	USP7	NNP
cord-012045-1cqqj84n	377	16	and	and	CC
cord-012045-1cqqj84n	377	17	inhibiting	inhibit	VBG
cord-012045-1cqqj84n	377	18	NEMO	NEMO	NNP
cord-012045-1cqqj84n	377	19	ubiquitination	ubiquitination	IN
cord-012045-1cqqj84n	377	20	HSV	HSV	NNP
cord-012045-1cqqj84n	377	21	ICP0	ICP0	NNP
cord-012045-1cqqj84n	377	22	recruits	recruit	VBZ
cord-012045-1cqqj84n	377	23	USP7	USP7	NNP
cord-012045-1cqqj84n	377	24	to	to	TO
cord-012045-1cqqj84n	377	25	modulate	modulate	VB
cord-012045-1cqqj84n	377	26	TLR	TLR	NNP
cord-012045-1cqqj84n	377	27	-	-	HYPH
cord-012045-1cqqj84n	377	28	mediated	mediate	VBN
cord-012045-1cqqj84n	377	29	innate	innate	JJ
cord-012045-1cqqj84n	377	30	response	response	NN
cord-012045-1cqqj84n	377	31	Inflammatory	Inflammatory	NNP
cord-012045-1cqqj84n	377	32	mechanisms	mechanism	NNS
cord-012045-1cqqj84n	377	33	in	in	IN
cord-012045-1cqqj84n	377	34	the	the	DT
cord-012045-1cqqj84n	377	35	lung	lung	NN
cord-012045-1cqqj84n	377	36	Destabilization	destabilization	NN
cord-012045-1cqqj84n	377	37	of	of	IN
cord-012045-1cqqj84n	377	38	Lysophosphatidic	Lysophosphatidic	NNP
cord-012045-1cqqj84n	377	39	Acid	Acid	NNP
cord-012045-1cqqj84n	377	40	Receptor	Receptor	NNP
cord-012045-1cqqj84n	377	41	1	1	CD
cord-012045-1cqqj84n	377	42	Reduces	reduce	VBZ
cord-012045-1cqqj84n	377	43	Cytokine	cytokine	NN
cord-012045-1cqqj84n	377	44	Release	Release	NNP
cord-012045-1cqqj84n	377	45	and	and	CC
cord-012045-1cqqj84n	377	46	Protects	protect	VBZ
cord-012045-1cqqj84n	377	47	Against	against	IN
cord-012045-1cqqj84n	377	48	Lung	Lung	NNP
cord-012045-1cqqj84n	377	49	Injury	injury	NN
cord-012045-1cqqj84n	378	1	The	the	DT
cord-012045-1cqqj84n	378	2	deubiquitinating	deubiquitinating	NN
cord-012045-1cqqj84n	378	3	enzyme	enzyme	NN
cord-012045-1cqqj84n	378	4	USP10	USP10	NNP
cord-012045-1cqqj84n	378	5	regulates	regulate	VBZ
cord-012045-1cqqj84n	378	6	the	the	DT
cord-012045-1cqqj84n	378	7	endocytic	endocytic	JJ
cord-012045-1cqqj84n	378	8	recycling	recycling	NN
cord-012045-1cqqj84n	378	9	of	of	IN
cord-012045-1cqqj84n	378	10	CFTR	CFTR	NNP
cord-012045-1cqqj84n	378	11	in	in	IN
cord-012045-1cqqj84n	378	12	airway	airway	NN
cord-012045-1cqqj84n	378	13	epithelial	epithelial	JJ
cord-012045-1cqqj84n	378	14	cells	cell	NNS
cord-012045-1cqqj84n	378	15	Lopez	Lopez	NNP
cord-012045-1cqqj84n	378	16	-	-	HYPH
cord-012045-1cqqj84n	378	17	Castejon	Castejon	NNP
cord-012045-1cqqj84n	378	18	,	,	,
cord-012045-1cqqj84n	378	19	G.	G.	NNP
cord-012045-1cqqj84n	378	20	USP7	USP7	NNP
cord-012045-1cqqj84n	378	21	and	and	CC
cord-012045-1cqqj84n	378	22	USP47	USP47	NNP
cord-012045-1cqqj84n	378	23	deubiquitinases	deubiquitinases	NNP
cord-012045-1cqqj84n	379	1	regulate	regulate	VB
cord-012045-1cqqj84n	379	2	NLRP3	NLRP3	NNP
cord-012045-1cqqj84n	379	3	inflammasome	inflammasome	NNP
cord-012045-1cqqj84n	379	4	activation	activation	NN
cord-012045-1cqqj84n	379	5	Deubiquitination	Deubiquitination	NNP
cord-012045-1cqqj84n	379	6	of	of	IN
cord-012045-1cqqj84n	379	7	NF	NF	NNP
cord-012045-1cqqj84n	379	8	-	-	HYPH
cord-012045-1cqqj84n	379	9	kappaB	kappaB	NNP
cord-012045-1cqqj84n	379	10	by	by	IN
cord-012045-1cqqj84n	379	11	Ubiquitin	Ubiquitin	NNP
cord-012045-1cqqj84n	379	12	-	-	HYPH
cord-012045-1cqqj84n	379	13	Specific	Specific	NNP
cord-012045-1cqqj84n	379	14	Protease-7	Protease-7	NNP
cord-012045-1cqqj84n	379	15	promotes	promote	VBZ
cord-012045-1cqqj84n	379	16	transcription	transcription	NN
cord-012045-1cqqj84n	380	1	The	the	DT
cord-012045-1cqqj84n	380	2	deubiquitinase	deubiquitinase	NN
cord-012045-1cqqj84n	380	3	USP13	usp13	RB
cord-012045-1cqqj84n	380	4	stabilizes	stabilize	VBZ
cord-012045-1cqqj84n	380	5	the	the	DT
cord-012045-1cqqj84n	380	6	anti	anti	JJ
cord-012045-1cqqj84n	380	7	-	-	JJ
cord-012045-1cqqj84n	380	8	inflammatory	inflammatory	JJ
cord-012045-1cqqj84n	380	9	receptor	receptor	NN
cord-012045-1cqqj84n	380	10	IL-1R8	il-1r8	NN
cord-012045-1cqqj84n	380	11	/	/	,
cord-012045-1cqqj84n	380	12	Sigirr	Sigirr	NNP
cord-012045-1cqqj84n	380	13	to	to	TO
cord-012045-1cqqj84n	380	14	suppress	suppress	VB
cord-012045-1cqqj84n	380	15	lung	lung	NN
cord-012045-1cqqj84n	380	16	inflammation	inflammation	NN
cord-012045-1cqqj84n	381	1	Down	down	IN
cord-012045-1cqqj84n	381	2	-	-	HYPH
cord-012045-1cqqj84n	381	3	regulation	regulation	NN
cord-012045-1cqqj84n	381	4	of	of	IN
cord-012045-1cqqj84n	381	5	USP13	USP13	NNP
cord-012045-1cqqj84n	381	6	mediates	mediate	VBZ
cord-012045-1cqqj84n	381	7	phenotype	phenotype	NN
cord-012045-1cqqj84n	381	8	transformation	transformation	NN
cord-012045-1cqqj84n	381	9	of	of	IN
cord-012045-1cqqj84n	381	10	fibroblasts	fibroblast	NNS
cord-012045-1cqqj84n	381	11	in	in	IN
cord-012045-1cqqj84n	381	12	idiopathic	idiopathic	JJ
cord-012045-1cqqj84n	381	13	pulmonary	pulmonary	JJ
cord-012045-1cqqj84n	381	14	fibrosis	fibrosis	NN
cord-012045-1cqqj84n	382	1	Deubiquitinase	Deubiquitinase	NNP
cord-012045-1cqqj84n	382	2	USP13	USP13	NNP
cord-012045-1cqqj84n	382	3	dictates	dictate	VBZ
cord-012045-1cqqj84n	382	4	MCL1	MCL1	NNP
cord-012045-1cqqj84n	382	5	stability	stability	NN
cord-012045-1cqqj84n	382	6	and	and	CC
cord-012045-1cqqj84n	382	7	sensitivity	sensitivity	NN
cord-012045-1cqqj84n	382	8	to	to	IN
cord-012045-1cqqj84n	382	9	BH3	bh3	NN
cord-012045-1cqqj84n	382	10	mimetic	mimetic	NN
cord-012045-1cqqj84n	382	11	inhibitors	inhibitor	NNS
cord-012045-1cqqj84n	382	12	Tumor	tumor	NN
cord-012045-1cqqj84n	382	13	suppressor	suppressor	NN
cord-012045-1cqqj84n	382	14	cylindromatosis	cylindromatosis	NN
cord-012045-1cqqj84n	382	15	acts	act	VBZ
cord-012045-1cqqj84n	382	16	as	as	IN
cord-012045-1cqqj84n	382	17	a	a	DT
cord-012045-1cqqj84n	382	18	negative	negative	JJ
cord-012045-1cqqj84n	382	19	regulator	regulator	NN
cord-012045-1cqqj84n	382	20	for	for	IN
cord-012045-1cqqj84n	382	21	Streptococcus	Streptococcus	NNP
cord-012045-1cqqj84n	382	22	pneumoniae	pneumoniae	NN
cord-012045-1cqqj84n	382	23	-	-	HYPH
cord-012045-1cqqj84n	382	24	induced	induce	VBN
cord-012045-1cqqj84n	382	25	NFAT	NFAT	NNP
cord-012045-1cqqj84n	382	26	signaling	signal	VBG
cord-012045-1cqqj84n	382	27	Cylindromatosis	Cylindromatosis	NNP
cord-012045-1cqqj84n	382	28	(	(	-LRB-
cord-012045-1cqqj84n	382	29	CYLD	CYLD	NNP
cord-012045-1cqqj84n	382	30	)	)	-RRB-
cord-012045-1cqqj84n	382	31	inhibits	inhibit	VBZ
cord-012045-1cqqj84n	382	32	Streptococcus	Streptococcus	NNP
cord-012045-1cqqj84n	382	33	pneumonia	pneumonia	NN
cord-012045-1cqqj84n	382	34	-	-	HYPH
cord-012045-1cqqj84n	382	35	induced	induce	VBN
cord-012045-1cqqj84n	382	36	plasminogen	plasminogen	NN
cord-012045-1cqqj84n	382	37	activator	activator	NN
cord-012045-1cqqj84n	382	38	inhibitor-1	inhibitor-1	NNP
cord-012045-1cqqj84n	382	39	expression	expression	NN
cord-012045-1cqqj84n	382	40	via	via	IN
cord-012045-1cqqj84n	382	41	interacting	interact	VBG
cord-012045-1cqqj84n	382	42	with	with	IN
cord-012045-1cqqj84n	382	43	TRAF-6	TRAF-6	NNP
cord-012045-1cqqj84n	383	1	The	the	DT
cord-012045-1cqqj84n	383	2	tumor	tumor	NN
cord-012045-1cqqj84n	383	3	suppressor	suppressor	NN
cord-012045-1cqqj84n	383	4	cylindromatosis	cylindromatosis	NN
cord-012045-1cqqj84n	383	5	(	(	-LRB-
cord-012045-1cqqj84n	383	6	CYLD	CYLD	NNP
cord-012045-1cqqj84n	383	7	)	)	-RRB-
cord-012045-1cqqj84n	383	8	acts	act	VBZ
cord-012045-1cqqj84n	383	9	as	as	IN
cord-012045-1cqqj84n	383	10	a	a	DT
cord-012045-1cqqj84n	383	11	negative	negative	JJ
cord-012045-1cqqj84n	383	12	regulator	regulator	NN
cord-012045-1cqqj84n	383	13	for	for	IN
cord-012045-1cqqj84n	383	14	toll	toll	NN
cord-012045-1cqqj84n	383	15	-	-	HYPH
cord-012045-1cqqj84n	383	16	like	like	JJ
cord-012045-1cqqj84n	383	17	receptor	receptor	NN
cord-012045-1cqqj84n	383	18	2	2	CD
cord-012045-1cqqj84n	383	19	signaling	signal	VBG
cord-012045-1cqqj84n	383	20	via	via	IN
cord-012045-1cqqj84n	383	21	negative	negative	JJ
cord-012045-1cqqj84n	383	22	cross	cross	NN
cord-012045-1cqqj84n	383	23	-	-	NN
cord-012045-1cqqj84n	383	24	talk	talk	VB
cord-012045-1cqqj84n	383	25	with	with	IN
cord-012045-1cqqj84n	383	26	TRAF6	TRAF6	NNP
cord-012045-1cqqj84n	384	1	AND	and	CC
cord-012045-1cqqj84n	384	2	TRAF7	TRAF7	NNP
cord-012045-1cqqj84n	384	3	Tumor	tumor	NN
cord-012045-1cqqj84n	384	4	suppressor	suppressor	NN
cord-012045-1cqqj84n	384	5	CYLD	CYLD	NNP
cord-012045-1cqqj84n	384	6	acts	act	VBZ
cord-012045-1cqqj84n	384	7	as	as	IN
cord-012045-1cqqj84n	384	8	a	a	DT
cord-012045-1cqqj84n	384	9	negative	negative	JJ
cord-012045-1cqqj84n	384	10	regulator	regulator	NN
cord-012045-1cqqj84n	384	11	for	for	IN
cord-012045-1cqqj84n	384	12	non	non	JJ
cord-012045-1cqqj84n	384	13	-	-	JJ
cord-012045-1cqqj84n	384	14	typeable	typeable	JJ
cord-012045-1cqqj84n	384	15	Haemophilus	Haemophilus	NNP
cord-012045-1cqqj84n	384	16	influenza	influenza	NN
cord-012045-1cqqj84n	384	17	-	-	HYPH
cord-012045-1cqqj84n	384	18	induced	induce	VBN
cord-012045-1cqqj84n	384	19	inflammation	inflammation	NN
cord-012045-1cqqj84n	384	20	in	in	IN
cord-012045-1cqqj84n	384	21	the	the	DT
cord-012045-1cqqj84n	384	22	middle	middle	JJ
cord-012045-1cqqj84n	384	23	ear	ear	NN
cord-012045-1cqqj84n	384	24	and	and	CC
cord-012045-1cqqj84n	384	25	lung	lung	NN
cord-012045-1cqqj84n	384	26	of	of	IN
cord-012045-1cqqj84n	384	27	mice	mouse	NNS
cord-012045-1cqqj84n	385	1	CYLD	CYLD	NNP
cord-012045-1cqqj84n	385	2	negatively	negatively	RB
cord-012045-1cqqj84n	385	3	regulates	regulate	VBZ
cord-012045-1cqqj84n	385	4	transforming	transform	VBG
cord-012045-1cqqj84n	385	5	growth	growth	NN
cord-012045-1cqqj84n	385	6	factor	factor	NN
cord-012045-1cqqj84n	386	1	-beta	-beta	:
cord-012045-1cqqj84n	386	2	-	-	HYPH
cord-012045-1cqqj84n	386	3	signalling	signal	VBG
cord-012045-1cqqj84n	386	4	via	via	IN
cord-012045-1cqqj84n	386	5	deubiquitinating	deubiquitinating	NN
cord-012045-1cqqj84n	387	1	Akt	Akt	NNP
cord-012045-1cqqj84n	387	2	Tumor	tumor	NN
cord-012045-1cqqj84n	387	3	suppressor	suppressor	NN
cord-012045-1cqqj84n	387	4	CYLD	CYLD	NNP
cord-012045-1cqqj84n	387	5	regulates	regulate	VBZ
cord-012045-1cqqj84n	387	6	acute	acute	JJ
cord-012045-1cqqj84n	387	7	lung	lung	NN
cord-012045-1cqqj84n	387	8	injury	injury	NN
cord-012045-1cqqj84n	387	9	in	in	IN
cord-012045-1cqqj84n	387	10	lethal	lethal	JJ
cord-012045-1cqqj84n	387	11	Streptococcus	streptococcus	NN
cord-012045-1cqqj84n	387	12	pneumoniae	pneumoniae	NN
cord-012045-1cqqj84n	387	13	infections	infection	NNS
cord-012045-1cqqj84n	387	14	Regulation	regulation	NN
cord-012045-1cqqj84n	387	15	of	of	IN
cord-012045-1cqqj84n	387	16	the	the	DT
cord-012045-1cqqj84n	387	17	Ebola	Ebola	NNP
cord-012045-1cqqj84n	387	18	Virus	Virus	NNP
cord-012045-1cqqj84n	387	19	VP24	VP24	NNP
cord-012045-1cqqj84n	387	20	Protein	Protein	NNP
cord-012045-1cqqj84n	387	21	by	by	IN
cord-012045-1cqqj84n	387	22	SUMO	SUMO	NNP
cord-012045-1cqqj84n	387	23	USP7	USP7	NNP
cord-012045-1cqqj84n	387	24	deubiquitinase	deubiquitinase	NN
cord-012045-1cqqj84n	388	1	controls	control	VBZ
cord-012045-1cqqj84n	388	2	HIV-1	HIV-1	NNP
cord-012045-1cqqj84n	388	3	production	production	NN
cord-012045-1cqqj84n	388	4	by	by	IN
cord-012045-1cqqj84n	388	5	stabilizing	stabilize	VBG
cord-012045-1cqqj84n	388	6	Tat	Tat	NNP
cord-012045-1cqqj84n	388	7	protein	protein	NN
cord-012045-1cqqj84n	388	8	USP7-Dependent	usp7-dependent	NN
cord-012045-1cqqj84n	388	9	Regulation	regulation	NN
cord-012045-1cqqj84n	388	10	of	of	IN
cord-012045-1cqqj84n	388	11	TRAF	TRAF	NNP
cord-012045-1cqqj84n	388	12	Activation	Activation	NNP
cord-012045-1cqqj84n	388	13	and	and	CC
cord-012045-1cqqj84n	388	14	Signaling	Signaling	NNP
cord-012045-1cqqj84n	388	15	by	by	IN
cord-012045-1cqqj84n	388	16	a	a	DT
cord-012045-1cqqj84n	388	17	Viral	Viral	NNP
cord-012045-1cqqj84n	388	18	Interferon	Interferon	NNP
cord-012045-1cqqj84n	388	19	Regulatory	Regulatory	NNP
cord-012045-1cqqj84n	388	20	Factor	Factor	NNP
cord-012045-1cqqj84n	388	21	Homologue	Homologue	NNP
cord-012045-1cqqj84n	388	22	A	a	DT
cord-012045-1cqqj84n	388	23	Pseudomonas	Pseudomonas	NNP
cord-012045-1cqqj84n	388	24	aeruginosa	aeruginosa	NN
cord-012045-1cqqj84n	388	25	toxin	toxin	NN
cord-012045-1cqqj84n	388	26	that	that	WDT
cord-012045-1cqqj84n	388	27	hijacks	hijack	VBZ
cord-012045-1cqqj84n	388	28	the	the	DT
cord-012045-1cqqj84n	388	29	host	host	NN
cord-012045-1cqqj84n	388	30	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	388	31	proteolytic	proteolytic	JJ
cord-012045-1cqqj84n	388	32	system	system	NN
cord-012045-1cqqj84n	389	1	Deubiquitinase	Deubiquitinase	NNP
cord-012045-1cqqj84n	389	2	USP10	USP10	NNP
cord-012045-1cqqj84n	389	3	regulates	regulate	VBZ
cord-012045-1cqqj84n	389	4	Notch	notch	NN
cord-012045-1cqqj84n	389	5	signaling	signal	VBG
cord-012045-1cqqj84n	389	6	in	in	IN
cord-012045-1cqqj84n	389	7	the	the	DT
cord-012045-1cqqj84n	389	8	endothelium	endothelium	NN
cord-012045-1cqqj84n	390	1	Phosphorylated	Phosphorylated	NNP
cord-012045-1cqqj84n	390	2	E2F1	E2F1	NNP
cord-012045-1cqqj84n	390	3	is	be	VBZ
cord-012045-1cqqj84n	390	4	stabilized	stabilize	VBN
cord-012045-1cqqj84n	390	5	by	by	IN
cord-012045-1cqqj84n	390	6	nuclear	nuclear	JJ
cord-012045-1cqqj84n	390	7	USP11	usp11	NN
cord-012045-1cqqj84n	390	8	to	to	TO
cord-012045-1cqqj84n	390	9	drive	drive	VB
cord-012045-1cqqj84n	390	10	Peg10	Peg10	NNP
cord-012045-1cqqj84n	390	11	gene	gene	NN
cord-012045-1cqqj84n	390	12	expression	expression	NN
cord-012045-1cqqj84n	390	13	and	and	CC
cord-012045-1cqqj84n	390	14	activate	activate	VB
cord-012045-1cqqj84n	390	15	lung	lung	NN
cord-012045-1cqqj84n	390	16	epithelial	epithelial	NN
cord-012045-1cqqj84n	390	17	cells	cell	NNS
cord-012045-1cqqj84n	390	18	Ubiquitin	Ubiquitin	NNP
cord-012045-1cqqj84n	390	19	-	-	HYPH
cord-012045-1cqqj84n	390	20	specific	specific	JJ
cord-012045-1cqqj84n	390	21	protease	protease	NN
cord-012045-1cqqj84n	390	22	13	13	CD
cord-012045-1cqqj84n	390	23	regulates	regulate	VBZ
cord-012045-1cqqj84n	390	24	IFN	IFN	NNP
cord-012045-1cqqj84n	390	25	signaling	signal	VBG
cord-012045-1cqqj84n	390	26	by	by	IN
cord-012045-1cqqj84n	390	27	stabilizing	stabilize	VBG
cord-012045-1cqqj84n	390	28	STAT1	stat1	NN
cord-012045-1cqqj84n	390	29	USP13	usp13	IN
cord-012045-1cqqj84n	390	30	negatively	negatively	RB
cord-012045-1cqqj84n	390	31	regulates	regulate	VBZ
cord-012045-1cqqj84n	390	32	antiviral	antiviral	JJ
cord-012045-1cqqj84n	390	33	responses	response	NNS
cord-012045-1cqqj84n	390	34	by	by	IN
cord-012045-1cqqj84n	390	35	deubiquitinating	deubiquitinate	VBG
cord-012045-1cqqj84n	390	36	STING	STING	NNP
cord-012045-1cqqj84n	390	37	ER	ER	NNP
cord-012045-1cqqj84n	390	38	-	-	HYPH
cord-012045-1cqqj84n	390	39	localized	localize	VBN
cord-012045-1cqqj84n	390	40	Hrd1	Hrd1	NNP
cord-012045-1cqqj84n	390	41	ubiquitinates	ubiquitinate	NNS
cord-012045-1cqqj84n	390	42	and	and	CC
cord-012045-1cqqj84n	390	43	inactivates	inactivate	VBZ
cord-012045-1cqqj84n	390	44	Usp15	Usp15	NNP
cord-012045-1cqqj84n	390	45	to	to	TO
cord-012045-1cqqj84n	390	46	promote	promote	VB
cord-012045-1cqqj84n	390	47	TLR4-induced	tlr4-induced	JJ
cord-012045-1cqqj84n	390	48	inflammation	inflammation	NN
cord-012045-1cqqj84n	390	49	during	during	IN
cord-012045-1cqqj84n	390	50	bacterial	bacterial	JJ
cord-012045-1cqqj84n	390	51	infection	infection	NN
cord-012045-1cqqj84n	390	52	USP17-mediated	usp17-mediated	CD
cord-012045-1cqqj84n	390	53	deubiquitination	deubiquitination	NN
cord-012045-1cqqj84n	390	54	and	and	CC
cord-012045-1cqqj84n	390	55	stabilization	stabilization	NN
cord-012045-1cqqj84n	390	56	of	of	IN
cord-012045-1cqqj84n	390	57	HDAC2	hdac2	NN
cord-012045-1cqqj84n	390	58	in	in	IN
cord-012045-1cqqj84n	390	59	cigarette	cigarette	NN
cord-012045-1cqqj84n	390	60	smoke	smoke	NN
cord-012045-1cqqj84n	390	61	extract	extract	NN
cord-012045-1cqqj84n	390	62	-	-	HYPH
cord-012045-1cqqj84n	390	63	induced	induce	VBN
cord-012045-1cqqj84n	390	64	inflammation	inflammation	NN
cord-012045-1cqqj84n	391	1	USP17	USP17	NNP
cord-012045-1cqqj84n	391	2	mediates	mediate	VBZ
cord-012045-1cqqj84n	391	3	macrophage	macrophage	NN
cord-012045-1cqqj84n	391	4	-	-	HYPH
cord-012045-1cqqj84n	391	5	promoted	promote	VBN
cord-012045-1cqqj84n	391	6	inflammation	inflammation	NN
cord-012045-1cqqj84n	391	7	and	and	CC
cord-012045-1cqqj84n	391	8	stemness	stemness	JJ
cord-012045-1cqqj84n	391	9	in	in	IN
cord-012045-1cqqj84n	391	10	lung	lung	NN
cord-012045-1cqqj84n	391	11	cancer	cancer	NN
cord-012045-1cqqj84n	391	12	cells	cell	NNS
cord-012045-1cqqj84n	391	13	by	by	IN
cord-012045-1cqqj84n	391	14	regulating	regulate	VBG
cord-012045-1cqqj84n	391	15	TRAF2	TRAF2	NNP
cord-012045-1cqqj84n	391	16	/	/	SYM
cord-012045-1cqqj84n	391	17	TRAF3	traf3	NN
cord-012045-1cqqj84n	391	18	complex	complex	JJ
cord-012045-1cqqj84n	391	19	formation	formation	NN
cord-012045-1cqqj84n	392	1	USP19	USP19	NNP
cord-012045-1cqqj84n	392	2	Inhibits	inhibit	VBZ
cord-012045-1cqqj84n	392	3	TNF	tnf	NN
cord-012045-1cqqj84n	392	4	-	-	HYPH
cord-012045-1cqqj84n	392	5	alpha	alpha	NN
cord-012045-1cqqj84n	392	6	-	-	HYPH
cord-012045-1cqqj84n	392	7	and	and	CC
cord-012045-1cqqj84n	392	8	IL-1beta	il-1beta	NN
cord-012045-1cqqj84n	392	9	-	-	HYPH
cord-012045-1cqqj84n	392	10	Triggered	trigger	VBN
cord-012045-1cqqj84n	392	11	NF	NF	NNP
cord-012045-1cqqj84n	392	12	-	-	HYPH
cord-012045-1cqqj84n	392	13	kappaB	kappaB	NNP
cord-012045-1cqqj84n	392	14	Activation	Activation	NNP
cord-012045-1cqqj84n	392	15	by	by	IN
cord-012045-1cqqj84n	392	16	Deubiquitinating	Deubiquitinating	NNP
cord-012045-1cqqj84n	392	17	TAK1	TAK1	NNP
cord-012045-1cqqj84n	392	18	Regulation	Regulation	NNP
cord-012045-1cqqj84n	392	19	of	of	IN
cord-012045-1cqqj84n	392	20	TRIF	TRIF	NNP
cord-012045-1cqqj84n	392	21	-	-	HYPH
cord-012045-1cqqj84n	392	22	mediated	mediate	VBN
cord-012045-1cqqj84n	392	23	innate	innate	JJ
cord-012045-1cqqj84n	392	24	immune	immune	JJ
cord-012045-1cqqj84n	392	25	response	response	NN
cord-012045-1cqqj84n	392	26	by	by	IN
cord-012045-1cqqj84n	392	27	K27-linked	k27-linked	JJ
cord-012045-1cqqj84n	392	28	polyubiquitination	polyubiquitination	NN
cord-012045-1cqqj84n	392	29	and	and	CC
cord-012045-1cqqj84n	392	30	deubiquitination	deubiquitination	NN
cord-012045-1cqqj84n	393	1	The	the	DT
cord-012045-1cqqj84n	393	2	BECN1-USP19	BECN1-USP19	NNP
cord-012045-1cqqj84n	393	3	axis	axis	NN
cord-012045-1cqqj84n	393	4	plays	play	VBZ
cord-012045-1cqqj84n	393	5	a	a	DT
cord-012045-1cqqj84n	393	6	role	role	NN
cord-012045-1cqqj84n	393	7	in	in	IN
cord-012045-1cqqj84n	393	8	the	the	DT
cord-012045-1cqqj84n	393	9	crosstalk	crosstalk	NN
cord-012045-1cqqj84n	393	10	between	between	IN
cord-012045-1cqqj84n	393	11	autophagy	autophagy	NN
cord-012045-1cqqj84n	393	12	and	and	CC
cord-012045-1cqqj84n	393	13	antiviral	antiviral	JJ
cord-012045-1cqqj84n	393	14	immune	immune	JJ
cord-012045-1cqqj84n	393	15	responses	response	NNS
cord-012045-1cqqj84n	393	16	Ubiquitin	Ubiquitin	NNP
cord-012045-1cqqj84n	393	17	-	-	HYPH
cord-012045-1cqqj84n	393	18	specific	specific	JJ
cord-012045-1cqqj84n	393	19	protease	protease	NN
cord-012045-1cqqj84n	393	20	25	25	CD
cord-012045-1cqqj84n	393	21	regulates	regulate	VBZ
cord-012045-1cqqj84n	393	22	TLR4-dependent	tlr4-dependent	NN
cord-012045-1cqqj84n	393	23	innate	innate	JJ
cord-012045-1cqqj84n	393	24	immune	immune	JJ
cord-012045-1cqqj84n	393	25	responses	response	NNS
cord-012045-1cqqj84n	393	26	through	through	IN
cord-012045-1cqqj84n	393	27	deubiquitination	deubiquitination	NN
cord-012045-1cqqj84n	393	28	of	of	IN
cord-012045-1cqqj84n	393	29	the	the	DT
cord-012045-1cqqj84n	393	30	adaptor	adaptor	NN
cord-012045-1cqqj84n	393	31	protein	protein	NN
cord-012045-1cqqj84n	394	1	TRAF3	TRAF3	NNP
cord-012045-1cqqj84n	395	1	Ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	395	2	-	-	HYPH
cord-012045-1cqqj84n	395	3	specific	specific	JJ
cord-012045-1cqqj84n	395	4	proteases	protease	NNS
cord-012045-1cqqj84n	395	5	25	25	CD
cord-012045-1cqqj84n	395	6	negatively	negatively	RB
cord-012045-1cqqj84n	395	7	regulates	regulate	VBZ
cord-012045-1cqqj84n	395	8	virus	virus	NN
cord-012045-1cqqj84n	395	9	-	-	HYPH
cord-012045-1cqqj84n	395	10	induced	induce	VBN
cord-012045-1cqqj84n	395	11	type	type	NN
cord-012045-1cqqj84n	396	1	I	-PRON-	PRP
cord-012045-1cqqj84n	396	2	interferon	interferon	VBP
cord-012045-1cqqj84n	396	3	signaling	signal	VBG
cord-012045-1cqqj84n	396	4	Induction	Induction	NNP
cord-012045-1cqqj84n	396	5	of	of	IN
cord-012045-1cqqj84n	396	6	USP25	USP25	NNP
cord-012045-1cqqj84n	396	7	by	by	IN
cord-012045-1cqqj84n	396	8	viral	viral	JJ
cord-012045-1cqqj84n	396	9	infection	infection	NN
cord-012045-1cqqj84n	397	1	promotes	promote	VBZ
cord-012045-1cqqj84n	397	2	innate	innate	JJ
cord-012045-1cqqj84n	397	3	antiviral	antiviral	JJ
cord-012045-1cqqj84n	397	4	responses	response	NNS
cord-012045-1cqqj84n	397	5	by	by	IN
cord-012045-1cqqj84n	397	6	mediating	mediate	VBG
cord-012045-1cqqj84n	397	7	the	the	DT
cord-012045-1cqqj84n	397	8	stabilization	stabilization	NN
cord-012045-1cqqj84n	397	9	of	of	IN
cord-012045-1cqqj84n	397	10	TRAF3	TRAF3	NNP
cord-012045-1cqqj84n	397	11	and	and	CC
cord-012045-1cqqj84n	397	12	TRAF6	TRAF6	NNP
cord-012045-1cqqj84n	398	1	Negative	negative	JJ
cord-012045-1cqqj84n	398	2	regulation	regulation	NN
cord-012045-1cqqj84n	398	3	of	of	IN
cord-012045-1cqqj84n	398	4	IL-17-mediated	il-17-mediated	JJ
cord-012045-1cqqj84n	398	5	signaling	signaling	NN
cord-012045-1cqqj84n	398	6	and	and	CC
cord-012045-1cqqj84n	398	7	inflammation	inflammation	NN
cord-012045-1cqqj84n	398	8	by	by	IN
cord-012045-1cqqj84n	398	9	the	the	DT
cord-012045-1cqqj84n	398	10	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	398	11	-	-	HYPH
cord-012045-1cqqj84n	398	12	specific	specific	JJ
cord-012045-1cqqj84n	398	13	protease	protease	NN
cord-012045-1cqqj84n	398	14	USP25	USP25	NNP
cord-012045-1cqqj84n	398	15	LPS	LPS	NNP
cord-012045-1cqqj84n	398	16	promotes	promote	VBZ
cord-012045-1cqqj84n	398	17	HBO1	HBO1	NNP
cord-012045-1cqqj84n	398	18	stability	stability	NN
cord-012045-1cqqj84n	398	19	via	via	IN
cord-012045-1cqqj84n	398	20	USP25	USP25	NNP
cord-012045-1cqqj84n	398	21	to	to	TO
cord-012045-1cqqj84n	398	22	modulate	modulate	VB
cord-012045-1cqqj84n	398	23	inflammatory	inflammatory	JJ
cord-012045-1cqqj84n	398	24	gene	gene	NN
cord-012045-1cqqj84n	398	25	transcription	transcription	NN
cord-012045-1cqqj84n	398	26	in	in	IN
cord-012045-1cqqj84n	398	27	THP-1	THP-1	NNP
cord-012045-1cqqj84n	398	28	cells	cell	NNS
cord-012045-1cqqj84n	398	29	Cigarette	cigarette	NN
cord-012045-1cqqj84n	398	30	smoke	smoke	NN
cord-012045-1cqqj84n	398	31	extract	extract	NN
cord-012045-1cqqj84n	398	32	modulates	modulate	VBZ
cord-012045-1cqqj84n	398	33	Pseudomonas	Pseudomonas	NNP
cord-012045-1cqqj84n	398	34	aeruginosa	aeruginosa	NN
cord-012045-1cqqj84n	398	35	bacterial	bacterial	JJ
cord-012045-1cqqj84n	398	36	load	load	NN
cord-012045-1cqqj84n	398	37	via	via	IN
cord-012045-1cqqj84n	398	38	USP25	USP25	NNP
cord-012045-1cqqj84n	398	39	/	/	SYM
cord-012045-1cqqj84n	398	40	HDAC11	HDAC11	NNP
cord-012045-1cqqj84n	398	41	axis	axis	NN
cord-012045-1cqqj84n	398	42	in	in	IN
cord-012045-1cqqj84n	398	43	lung	lung	NN
cord-012045-1cqqj84n	398	44	epithelial	epithelial	NN
cord-012045-1cqqj84n	398	45	cells	cell	NNS
cord-012045-1cqqj84n	399	1	The	the	DT
cord-012045-1cqqj84n	399	2	deubiquitinating	deubiquitinating	NN
cord-012045-1cqqj84n	399	3	enzyme	enzyme	NN
cord-012045-1cqqj84n	399	4	USP48	USP48	NNP
cord-012045-1cqqj84n	399	5	stabilizes	stabilize	VBZ
cord-012045-1cqqj84n	399	6	TRAF2	TRAF2	NNP
cord-012045-1cqqj84n	399	7	and	and	CC
cord-012045-1cqqj84n	399	8	reduces	reduce	VBZ
cord-012045-1cqqj84n	399	9	E	e	NN
cord-012045-1cqqj84n	399	10	-	-	NN
cord-012045-1cqqj84n	399	11	cadherin	cadherin	NN
cord-012045-1cqqj84n	399	12	-	-	HYPH
cord-012045-1cqqj84n	399	13	mediated	mediate	VBN
cord-012045-1cqqj84n	399	14	adherens	adheren	NNS
cord-012045-1cqqj84n	399	15	junctions	junction	NNS
cord-012045-1cqqj84n	400	1	Ubiquitin	Ubiquitin	NNP
cord-012045-1cqqj84n	400	2	carboxyl	carboxyl	NN
cord-012045-1cqqj84n	400	3	-	-	HYPH
cord-012045-1cqqj84n	400	4	terminal	terminal	NN
cord-012045-1cqqj84n	400	5	hydrolase	hydrolase	NN
cord-012045-1cqqj84n	400	6	-	-	HYPH
cord-012045-1cqqj84n	400	7	L5	L5	NNP
cord-012045-1cqqj84n	400	8	promotes	promote	VBZ
cord-012045-1cqqj84n	400	9	TGFbeta-1	tgfbeta-1	JJ
cord-012045-1cqqj84n	400	10	signaling	signal	VBG
cord-012045-1cqqj84n	400	11	by	by	IN
cord-012045-1cqqj84n	400	12	de	de	JJ
cord-012045-1cqqj84n	400	13	-	-	JJ
cord-012045-1cqqj84n	400	14	ubiquitinating	ubiquitinating	JJ
cord-012045-1cqqj84n	400	15	and	and	CC
cord-012045-1cqqj84n	400	16	stabilizing	stabilize	VBG
cord-012045-1cqqj84n	400	17	Smad2/	Smad2/	NNP
cord-012045-1cqqj84n	401	1	Smad3	Smad3	NNP
cord-012045-1cqqj84n	402	1	in	in	IN
cord-012045-1cqqj84n	402	2	pulmonary	pulmonary	JJ
cord-012045-1cqqj84n	402	3	fibrosis	fibrosis	NN
cord-012045-1cqqj84n	402	4	OTULIN	OTULIN	NNP
cord-012045-1cqqj84n	402	5	restricts	restrict	VBZ
cord-012045-1cqqj84n	402	6	Met1-linked	Met1-linked	NNP
cord-012045-1cqqj84n	402	7	ubiquitination	ubiquitination	NN
cord-012045-1cqqj84n	402	8	to	to	TO
cord-012045-1cqqj84n	402	9	control	control	VB
cord-012045-1cqqj84n	402	10	innate	innate	JJ
cord-012045-1cqqj84n	402	11	immune	immune	NN
cord-012045-1cqqj84n	402	12	signaling	signal	VBG
cord-012045-1cqqj84n	402	13	OTULIN	OTULIN	NNP
cord-012045-1cqqj84n	402	14	antagonizes	antagonize	VBZ
cord-012045-1cqqj84n	402	15	LUBAC	LUBAC	NNP
cord-012045-1cqqj84n	402	16	signaling	signal	VBG
cord-012045-1cqqj84n	402	17	by	by	IN
cord-012045-1cqqj84n	402	18	specifically	specifically	RB
cord-012045-1cqqj84n	402	19	hydrolyzing	hydrolyze	VBG
cord-012045-1cqqj84n	402	20	Met1-linked	Met1-linked	NNP
cord-012045-1cqqj84n	402	21	polyubiquitin	polyubiquitin	NNS
cord-012045-1cqqj84n	403	1	The	the	DT
cord-012045-1cqqj84n	403	2	Deubiquitinase	Deubiquitinase	NNP
cord-012045-1cqqj84n	403	3	OTULIN	OTULIN	NNP
cord-012045-1cqqj84n	403	4	Is	be	VBZ
cord-012045-1cqqj84n	403	5	an	an	DT
cord-012045-1cqqj84n	403	6	Essential	essential	JJ
cord-012045-1cqqj84n	403	7	Negative	negative	JJ
cord-012045-1cqqj84n	403	8	Regulator	regulator	NN
cord-012045-1cqqj84n	403	9	of	of	IN
cord-012045-1cqqj84n	403	10	Inflammation	Inflammation	NNP
cord-012045-1cqqj84n	403	11	and	and	CC
cord-012045-1cqqj84n	403	12	Autoimmunity	Autoimmunity	NNP
cord-012045-1cqqj84n	403	13	Regulation	Regulation	NNP
cord-012045-1cqqj84n	403	14	of	of	IN
cord-012045-1cqqj84n	403	15	the	the	DT
cord-012045-1cqqj84n	403	16	linear	linear	JJ
cord-012045-1cqqj84n	403	17	ubiquitination	ubiquitination	NN
cord-012045-1cqqj84n	403	18	of	of	IN
cord-012045-1cqqj84n	403	19	STAT1	stat1	NN
cord-012045-1cqqj84n	403	20	controls	control	NNS
cord-012045-1cqqj84n	404	1	antiviral	antiviral	JJ
cord-012045-1cqqj84n	404	2	interferon	interferon	NN
cord-012045-1cqqj84n	404	3	signaling	signal	VBG
cord-012045-1cqqj84n	404	4	Regulation	regulation	NN
cord-012045-1cqqj84n	404	5	of	of	IN
cord-012045-1cqqj84n	405	1	virus	virus	NN
cord-012045-1cqqj84n	405	2	-	-	HYPH
cord-012045-1cqqj84n	405	3	triggered	trigger	VBN
cord-012045-1cqqj84n	405	4	signaling	signaling	NN
cord-012045-1cqqj84n	405	5	by	by	IN
cord-012045-1cqqj84n	406	1	OTUB1-and	OTUB1-and	NNP
cord-012045-1cqqj84n	406	2	OTUB2-mediated	otub2-mediated	JJ
cord-012045-1cqqj84n	406	3	deubiquitination	deubiquitination	NN
cord-012045-1cqqj84n	406	4	of	of	IN
cord-012045-1cqqj84n	406	5	TRAF3	TRAF3	NNP
cord-012045-1cqqj84n	407	1	and	and	CC
cord-012045-1cqqj84n	407	2	TRAF6	TRAF6	NNP
cord-012045-1cqqj84n	407	3	The	the	DT
cord-012045-1cqqj84n	407	4	deubiquitinase	deubiquitinase	NN
cord-012045-1cqqj84n	407	5	OTUB1	otub1	NN
cord-012045-1cqqj84n	407	6	augments	augment	VBZ
cord-012045-1cqqj84n	407	7	NF	nf	NN
cord-012045-1cqqj84n	407	8	-	-	HYPH
cord-012045-1cqqj84n	407	9	kappaB	kappaB	NNP
cord-012045-1cqqj84n	407	10	-	-	HYPH
cord-012045-1cqqj84n	407	11	dependent	dependent	JJ
cord-012045-1cqqj84n	407	12	immune	immune	JJ
cord-012045-1cqqj84n	407	13	responses	response	NNS
cord-012045-1cqqj84n	407	14	in	in	IN
cord-012045-1cqqj84n	407	15	dendritic	dendritic	JJ
cord-012045-1cqqj84n	407	16	cells	cell	NNS
cord-012045-1cqqj84n	407	17	in	in	IN
cord-012045-1cqqj84n	407	18	infection	infection	NN
cord-012045-1cqqj84n	407	19	and	and	CC
cord-012045-1cqqj84n	407	20	inflammation	inflammation	NN
cord-012045-1cqqj84n	407	21	by	by	IN
cord-012045-1cqqj84n	407	22	stabilizing	stabilize	VBG
cord-012045-1cqqj84n	407	23	UBC13	UBC13	NNP
cord-012045-1cqqj84n	408	1	The	the	DT
cord-012045-1cqqj84n	408	2	deubiquitinase	deubiquitinase	NN
cord-012045-1cqqj84n	408	3	Otub1	Otub1	NNP
cord-012045-1cqqj84n	408	4	controls	control	VBZ
cord-012045-1cqqj84n	408	5	the	the	DT
cord-012045-1cqqj84n	408	6	activation	activation	NN
cord-012045-1cqqj84n	408	7	of	of	IN
cord-012045-1cqqj84n	408	8	CD8(+	CD8(+	NNP
cord-012045-1cqqj84n	408	9	)	)	-RRB-
cord-012045-1cqqj84n	408	10	T	t	NN
cord-012045-1cqqj84n	408	11	cells	cell	NNS
cord-012045-1cqqj84n	408	12	and	and	CC
cord-012045-1cqqj84n	408	13	NK	NK	NNP
cord-012045-1cqqj84n	408	14	cells	cell	NNS
cord-012045-1cqqj84n	408	15	by	by	IN
cord-012045-1cqqj84n	408	16	regulating	regulate	VBG
cord-012045-1cqqj84n	408	17	IL-15-mediated	il-15-mediate	VBN
cord-012045-1cqqj84n	408	18	priming	prime	VBG
cord-012045-1cqqj84n	408	19	Post	post	JJ
cord-012045-1cqqj84n	408	20	-	-	JJ
cord-012045-1cqqj84n	408	21	translational	translational	JJ
cord-012045-1cqqj84n	408	22	modification	modification	NN
cord-012045-1cqqj84n	408	23	of	of	IN
cord-012045-1cqqj84n	408	24	the	the	DT
cord-012045-1cqqj84n	408	25	deubiquitinating	deubiquitinating	NN
cord-012045-1cqqj84n	408	26	enzyme	enzyme	NN
cord-012045-1cqqj84n	408	27	otubain	otubain	NN
cord-012045-1cqqj84n	408	28	1	1	CD
cord-012045-1cqqj84n	409	1	modulates	modulate	VBZ
cord-012045-1cqqj84n	409	2	active	active	JJ
cord-012045-1cqqj84n	409	3	RhoA	RhoA	NNP
cord-012045-1cqqj84n	409	4	levels	level	NNS
cord-012045-1cqqj84n	409	5	and	and	CC
cord-012045-1cqqj84n	409	6	susceptibility	susceptibility	NN
cord-012045-1cqqj84n	409	7	to	to	IN
cord-012045-1cqqj84n	409	8	Yersinia	Yersinia	NNP
cord-012045-1cqqj84n	409	9	invasion	invasion	NN
cord-012045-1cqqj84n	410	1	OTUB1	OTUB1	NNP
cord-012045-1cqqj84n	411	1	Is	be	VBZ
cord-012045-1cqqj84n	411	2	a	a	DT
cord-012045-1cqqj84n	411	3	Key	key	JJ
cord-012045-1cqqj84n	411	4	Regulator	Regulator	NNP
cord-012045-1cqqj84n	411	5	of	of	IN
cord-012045-1cqqj84n	411	6	RIG	rig	NN
cord-012045-1cqqj84n	411	7	-	-	HYPH
cord-012045-1cqqj84n	411	8	I	I	NNP
cord-012045-1cqqj84n	411	9	-	-	HYPH
cord-012045-1cqqj84n	411	10	Dependent	dependent	JJ
cord-012045-1cqqj84n	411	11	Immune	immune	NN
cord-012045-1cqqj84n	411	12	Signaling	signaling	NN
cord-012045-1cqqj84n	411	13	and	and	CC
cord-012045-1cqqj84n	411	14	Is	be	VBZ
cord-012045-1cqqj84n	411	15	Targeted	target	VBN
cord-012045-1cqqj84n	411	16	for	for	IN
cord-012045-1cqqj84n	411	17	Proteasomal	Proteasomal	NNP
cord-012045-1cqqj84n	411	18	Degradation	Degradation	NNP
cord-012045-1cqqj84n	411	19	by	by	IN
cord-012045-1cqqj84n	411	20	Influenza	Influenza	NNP
cord-012045-1cqqj84n	411	21	A	A	NNP
cord-012045-1cqqj84n	411	22	NS1	ns1	NN
cord-012045-1cqqj84n	411	23	OTUB1	otub1	NN
cord-012045-1cqqj84n	412	1	enhances	enhance	VBZ
cord-012045-1cqqj84n	412	2	TGFbeta	TGFbeta	NNP
cord-012045-1cqqj84n	412	3	signalling	signalling	NN
cord-012045-1cqqj84n	412	4	by	by	IN
cord-012045-1cqqj84n	412	5	inhibiting	inhibit	VBG
cord-012045-1cqqj84n	412	6	the	the	DT
cord-012045-1cqqj84n	412	7	ubiquitylation	ubiquitylation	NN
cord-012045-1cqqj84n	412	8	and	and	CC
cord-012045-1cqqj84n	412	9	degradation	degradation	NN
cord-012045-1cqqj84n	412	10	of	of	IN
cord-012045-1cqqj84n	412	11	active	active	JJ
cord-012045-1cqqj84n	412	12	SMAD2/3	SMAD2/3	NNP
cord-012045-1cqqj84n	412	13	Induction	Induction	NNP
cord-012045-1cqqj84n	412	14	of	of	IN
cord-012045-1cqqj84n	412	15	OTUD1	OTUD1	NNP
cord-012045-1cqqj84n	412	16	by	by	IN
cord-012045-1cqqj84n	412	17	RNA	RNA	NNP
cord-012045-1cqqj84n	412	18	viruses	virus	NNS
cord-012045-1cqqj84n	413	1	potently	potently	RB
cord-012045-1cqqj84n	413	2	inhibits	inhibit	VBZ
cord-012045-1cqqj84n	413	3	innate	innate	JJ
cord-012045-1cqqj84n	413	4	immune	immune	JJ
cord-012045-1cqqj84n	413	5	responses	response	NNS
cord-012045-1cqqj84n	413	6	by	by	IN
cord-012045-1cqqj84n	413	7	promoting	promote	VBG
cord-012045-1cqqj84n	413	8	degradation	degradation	NN
cord-012045-1cqqj84n	413	9	of	of	IN
cord-012045-1cqqj84n	413	10	the	the	DT
cord-012045-1cqqj84n	413	11	MAVS	MAVS	NNPS
cord-012045-1cqqj84n	413	12	/	/	SYM
cord-012045-1cqqj84n	413	13	TRAF3	TRAF3	NNP
cord-012045-1cqqj84n	413	14	/	/	SYM
cord-012045-1cqqj84n	413	15	TRAF6	TRAF6	NNP
cord-012045-1cqqj84n	413	16	signalosome	signalosome	NNP
cord-012045-1cqqj84n	413	17	Mutations	Mutations	NNPS
cord-012045-1cqqj84n	413	18	of	of	IN
cord-012045-1cqqj84n	413	19	deubiquitinase	deubiquitinase	NNP
cord-012045-1cqqj84n	413	20	OTUD1	OTUD1	NNP
cord-012045-1cqqj84n	413	21	are	be	VBP
cord-012045-1cqqj84n	413	22	associated	associate	VBN
cord-012045-1cqqj84n	413	23	with	with	IN
cord-012045-1cqqj84n	413	24	autoimmune	autoimmune	JJ
cord-012045-1cqqj84n	413	25	disorders	disorder	NNS
cord-012045-1cqqj84n	414	1	OTUD1	otud1	NN
cord-012045-1cqqj84n	415	1	Negatively	negatively	RB
cord-012045-1cqqj84n	415	2	Regulates	regulate	VBZ
cord-012045-1cqqj84n	415	3	Type	type	NN
cord-012045-1cqqj84n	415	4	I	-PRON-	PRP
cord-012045-1cqqj84n	415	5	IFN	IFN	NNP
cord-012045-1cqqj84n	415	6	Induction	Induction	NNP
cord-012045-1cqqj84n	415	7	by	by	IN
cord-012045-1cqqj84n	415	8	Disrupting	disrupt	VBG
cord-012045-1cqqj84n	415	9	Noncanonical	Noncanonical	NNP
cord-012045-1cqqj84n	415	10	Ubiquitination	Ubiquitination	NNP
cord-012045-1cqqj84n	415	11	of	of	IN
cord-012045-1cqqj84n	415	12	IRF3	IRF3	NNP
cord-012045-1cqqj84n	416	1	OTUD4	OTUD4	NNP
cord-012045-1cqqj84n	417	1	Is	be	VBZ
cord-012045-1cqqj84n	417	2	a	a	DT
cord-012045-1cqqj84n	417	3	Phospho	Phospho	NNP
cord-012045-1cqqj84n	417	4	-	-	HYPH
cord-012045-1cqqj84n	417	5	Activated	activate	VBN
cord-012045-1cqqj84n	417	6	K63	K63	NNP
cord-012045-1cqqj84n	417	7	Deubiquitinase	Deubiquitinase	NNP
cord-012045-1cqqj84n	417	8	that	that	WDT
cord-012045-1cqqj84n	417	9	Regulates	regulate	VBZ
cord-012045-1cqqj84n	417	10	MyD88-Dependent	MyD88-Dependent	NNP
cord-012045-1cqqj84n	418	1	Signaling	signal	VBG
cord-012045-1cqqj84n	418	2	Induction	Induction	NNP
cord-012045-1cqqj84n	418	3	of	of	IN
cord-012045-1cqqj84n	418	4	OTUD4	OTUD4	NNPS
cord-012045-1cqqj84n	418	5	by	by	IN
cord-012045-1cqqj84n	418	6	viral	viral	JJ
cord-012045-1cqqj84n	418	7	infection	infection	NN
cord-012045-1cqqj84n	418	8	promotes	promote	VBZ
cord-012045-1cqqj84n	418	9	antiviral	antiviral	JJ
cord-012045-1cqqj84n	418	10	responses	response	NNS
cord-012045-1cqqj84n	418	11	through	through	IN
cord-012045-1cqqj84n	418	12	deubiquitinating	deubiquitinating	NN
cord-012045-1cqqj84n	418	13	and	and	CC
cord-012045-1cqqj84n	418	14	stabilizing	stabilize	VBG
cord-012045-1cqqj84n	418	15	MAVS	MAVS	NNPS
cord-012045-1cqqj84n	419	1	Noncanonical	noncanonical	JJ
cord-012045-1cqqj84n	419	2	regulation	regulation	NN
cord-012045-1cqqj84n	419	3	of	of	IN
cord-012045-1cqqj84n	419	4	alkylation	alkylation	NN
cord-012045-1cqqj84n	419	5	damage	damage	NN
cord-012045-1cqqj84n	419	6	resistance	resistance	NN
cord-012045-1cqqj84n	419	7	by	by	IN
cord-012045-1cqqj84n	419	8	the	the	DT
cord-012045-1cqqj84n	419	9	OTUD4	OTUD4	NNP
cord-012045-1cqqj84n	419	10	deubiquitinase	deubiquitinase	NN
cord-012045-1cqqj84n	420	1	The	the	DT
cord-012045-1cqqj84n	420	2	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	420	3	-	-	HYPH
cord-012045-1cqqj84n	420	4	modifying	modify	VBG
cord-012045-1cqqj84n	420	5	enzyme	enzyme	NN
cord-012045-1cqqj84n	420	6	A20	A20	NNP
cord-012045-1cqqj84n	420	7	is	be	VBZ
cord-012045-1cqqj84n	420	8	required	require	VBN
cord-012045-1cqqj84n	420	9	for	for	IN
cord-012045-1cqqj84n	420	10	termination	termination	NN
cord-012045-1cqqj84n	420	11	of	of	IN
cord-012045-1cqqj84n	420	12	Toll	Toll	NNP
cord-012045-1cqqj84n	420	13	-	-	HYPH
cord-012045-1cqqj84n	420	14	like	like	JJ
cord-012045-1cqqj84n	420	15	receptor	receptor	NN
cord-012045-1cqqj84n	420	16	responses	response	NNS
cord-012045-1cqqj84n	420	17	Inhibition	Inhibition	NNP
cord-012045-1cqqj84n	420	18	of	of	IN
cord-012045-1cqqj84n	420	19	NF	NF	NNP
cord-012045-1cqqj84n	420	20	-	-	HYPH
cord-012045-1cqqj84n	420	21	kappaB	kappaB	NNP
cord-012045-1cqqj84n	420	22	signaling	signal	VBG
cord-012045-1cqqj84n	420	23	by	by	IN
cord-012045-1cqqj84n	420	24	A20	A20	NNP
cord-012045-1cqqj84n	420	25	through	through	IN
cord-012045-1cqqj84n	420	26	disruption	disruption	NN
cord-012045-1cqqj84n	420	27	of	of	IN
cord-012045-1cqqj84n	420	28	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	420	29	enzyme	enzyme	NN
cord-012045-1cqqj84n	420	30	complexes	complex	NNS
cord-012045-1cqqj84n	420	31	Klf4	Klf4	NNP
cord-012045-1cqqj84n	420	32	Alleviates	alleviate	VBZ
cord-012045-1cqqj84n	420	33	Lipopolysaccharide	Lipopolysaccharide	NNP
cord-012045-1cqqj84n	420	34	-	-	HYPH
cord-012045-1cqqj84n	420	35	Induced	induce	VBN
cord-012045-1cqqj84n	420	36	Inflammation	inflammation	NN
cord-012045-1cqqj84n	420	37	by	by	IN
cord-012045-1cqqj84n	420	38	Inducing	induce	VBG
cord-012045-1cqqj84n	420	39	Expression	expression	NN
cord-012045-1cqqj84n	420	40	of	of	IN
cord-012045-1cqqj84n	420	41	MCP-1	MCP-1	NNP
cord-012045-1cqqj84n	420	42	Induced	Induced	NNP
cord-012045-1cqqj84n	420	43	Protein	Protein	NNP
cord-012045-1cqqj84n	420	44	1	1	CD
cord-012045-1cqqj84n	420	45	to	to	IN
cord-012045-1cqqj84n	420	46	Deubiquitinate	Deubiquitinate	NNP
cord-012045-1cqqj84n	421	1	TRAF6	TRAF6	NNP
cord-012045-1cqqj84n	421	2	ATXN3	ATXN3	NNP
cord-012045-1cqqj84n	422	1	Positively	positively	RB
cord-012045-1cqqj84n	422	2	Regulates	regulate	VBZ
cord-012045-1cqqj84n	423	1	Type	type	NN
cord-012045-1cqqj84n	423	2	I	-PRON-	PRP
cord-012045-1cqqj84n	423	3	IFN	IFN	NNP
cord-012045-1cqqj84n	423	4	Antiviral	Antiviral	NNP
cord-012045-1cqqj84n	423	5	Response	Response	NNP
cord-012045-1cqqj84n	423	6	by	by	IN
cord-012045-1cqqj84n	423	7	Deubiquitinating	Deubiquitinating	NNP
cord-012045-1cqqj84n	423	8	and	and	CC
cord-012045-1cqqj84n	423	9	Stabilizing	stabilize	VBG
cord-012045-1cqqj84n	424	1	HDAC3	HDAC3	NNP
cord-012045-1cqqj84n	425	1	JOSD1	JOSD1	NNP
cord-012045-1cqqj84n	425	2	inhibits	inhibit	VBZ
cord-012045-1cqqj84n	425	3	mitochondrial	mitochondrial	JJ
cord-012045-1cqqj84n	425	4	apoptotic	apoptotic	JJ
cord-012045-1cqqj84n	425	5	signalling	signalling	NN
cord-012045-1cqqj84n	425	6	to	to	TO
cord-012045-1cqqj84n	425	7	drive	drive	VB
cord-012045-1cqqj84n	425	8	acquired	acquire	VBN
cord-012045-1cqqj84n	425	9	chemoresistance	chemoresistance	NN
cord-012045-1cqqj84n	425	10	in	in	IN
cord-012045-1cqqj84n	425	11	gynaecological	gynaecological	JJ
cord-012045-1cqqj84n	425	12	cancer	cancer	NN
cord-012045-1cqqj84n	425	13	by	by	IN
cord-012045-1cqqj84n	425	14	stabilizing	stabilize	VBG
cord-012045-1cqqj84n	425	15	MCL1	MCL1	NNP
cord-012045-1cqqj84n	425	16	JOSD1	josd1	XX
cord-012045-1cqqj84n	426	1	Negatively	negatively	RB
cord-012045-1cqqj84n	426	2	Regulates	regulate	VBZ
cord-012045-1cqqj84n	426	3	Type	type	NN
cord-012045-1cqqj84n	426	4	-	-	:
cord-012045-1cqqj84n	426	5	I	I	NNP
cord-012045-1cqqj84n	426	6	Interferon	Interferon	NNP
cord-012045-1cqqj84n	426	7	Antiviral	Antiviral	NNP
cord-012045-1cqqj84n	426	8	Activity	Activity	NNP
cord-012045-1cqqj84n	426	9	by	by	IN
cord-012045-1cqqj84n	426	10	Deubiquitinating	Deubiquitinating	NNP
cord-012045-1cqqj84n	426	11	and	and	CC
cord-012045-1cqqj84n	426	12	Stabilizing	stabilize	VBG
cord-012045-1cqqj84n	426	13	SOCS1	SOCS1	NNP
cord-012045-1cqqj84n	427	1	POH1	POH1	NNP
cord-012045-1cqqj84n	427	2	deubiquitinates	deubiquitinate	NNS
cord-012045-1cqqj84n	427	3	pro	pro	JJ
cord-012045-1cqqj84n	427	4	-	-	JJ
cord-012045-1cqqj84n	427	5	interleukin-1beta	interleukin-1beta	JJ
cord-012045-1cqqj84n	427	6	and	and	CC
cord-012045-1cqqj84n	427	7	restricts	restrict	VBZ
cord-012045-1cqqj84n	427	8	inflammasome	inflammasome	NN
cord-012045-1cqqj84n	427	9	activity	activity	NN
cord-012045-1cqqj84n	427	10	Deubiquitination	Deubiquitination	NNP
cord-012045-1cqqj84n	427	11	of	of	IN
cord-012045-1cqqj84n	427	12	NLRP3	nlrp3	XX
cord-012045-1cqqj84n	428	1	by	by	IN
cord-012045-1cqqj84n	428	2	BRCC3	BRCC3	NNP
cord-012045-1cqqj84n	428	3	critically	critically	RB
cord-012045-1cqqj84n	428	4	regulates	regulate	VBZ
cord-012045-1cqqj84n	428	5	inflammasome	inflammasome	NN
cord-012045-1cqqj84n	428	6	activity	activity	NN
cord-012045-1cqqj84n	428	7	Targeting	target	VBG
cord-012045-1cqqj84n	428	8	the	the	DT
cord-012045-1cqqj84n	428	9	deubiquitinase	deubiquitinase	NN
cord-012045-1cqqj84n	429	1	STAMBP	STAMBP	NNP
cord-012045-1cqqj84n	429	2	inhibits	inhibit	VBZ
cord-012045-1cqqj84n	429	3	NALP7	nalp7	JJ
cord-012045-1cqqj84n	429	4	inflammasome	inflammasome	NN
cord-012045-1cqqj84n	429	5	activity	activity	NN
cord-012045-1cqqj84n	430	1	Diverse	diverse	JJ
cord-012045-1cqqj84n	430	2	macrophage	macrophage	NN
cord-012045-1cqqj84n	430	3	populations	population	NNS
cord-012045-1cqqj84n	430	4	mediate	mediate	VBP
cord-012045-1cqqj84n	430	5	acute	acute	JJ
cord-012045-1cqqj84n	430	6	lung	lung	NN
cord-012045-1cqqj84n	430	7	inflammation	inflammation	NN
cord-012045-1cqqj84n	430	8	and	and	CC
cord-012045-1cqqj84n	430	9	resolution	resolution	NN
cord-012045-1cqqj84n	431	1	The	the	DT
cord-012045-1cqqj84n	431	2	contributions	contribution	NNS
cord-012045-1cqqj84n	431	3	of	of	IN
cord-012045-1cqqj84n	431	4	lung	lung	NN
cord-012045-1cqqj84n	431	5	macrophage	macrophage	NN
cord-012045-1cqqj84n	431	6	and	and	CC
cord-012045-1cqqj84n	431	7	monocyte	monocyte	NNP
cord-012045-1cqqj84n	431	8	heterogeneity	heterogeneity	NN
cord-012045-1cqqj84n	431	9	to	to	IN
cord-012045-1cqqj84n	431	10	influenza	influenza	NN
cord-012045-1cqqj84n	431	11	pathogenesis	pathogenesis	NN
cord-012045-1cqqj84n	431	12	ABRO1	ABRO1	NNP
cord-012045-1cqqj84n	431	13	promotes	promote	VBZ
cord-012045-1cqqj84n	431	14	NLRP3	NLRP3	NNP
cord-012045-1cqqj84n	431	15	inflammasome	inflammasome	NNP
cord-012045-1cqqj84n	431	16	activation	activation	NN
cord-012045-1cqqj84n	431	17	through	through	IN
cord-012045-1cqqj84n	431	18	regulation	regulation	NN
cord-012045-1cqqj84n	431	19	of	of	IN
cord-012045-1cqqj84n	431	20	NLRP3	NLRP3	NNP
cord-012045-1cqqj84n	431	21	deubiquitination	deubiquitination	NN
cord-012045-1cqqj84n	432	1	NLRP3	NLRP3	NNP
cord-012045-1cqqj84n	433	1	Phosphorylation	Phosphorylation	NNP
cord-012045-1cqqj84n	433	2	Is	be	VBZ
cord-012045-1cqqj84n	433	3	an	an	DT
cord-012045-1cqqj84n	433	4	Essential	Essential	NNP
cord-012045-1cqqj84n	433	5	Priming	Priming	NNP
cord-012045-1cqqj84n	433	6	Event	event	NN
cord-012045-1cqqj84n	433	7	for	for	IN
cord-012045-1cqqj84n	433	8	Inflammasome	Inflammasome	NNP
cord-012045-1cqqj84n	433	9	Activation	Activation	NNP
cord-012045-1cqqj84n	433	10	Loss	Loss	NNP
cord-012045-1cqqj84n	433	11	of	of	IN
cord-012045-1cqqj84n	433	12	the	the	DT
cord-012045-1cqqj84n	433	13	cylindromatosis	cylindromatosis	NN
cord-012045-1cqqj84n	433	14	tumour	tumour	NN
cord-012045-1cqqj84n	433	15	suppressor	suppressor	NN
cord-012045-1cqqj84n	433	16	inhibits	inhibit	VBZ
cord-012045-1cqqj84n	433	17	apoptosis	apoptosis	NN
cord-012045-1cqqj84n	433	18	by	by	IN
cord-012045-1cqqj84n	433	19	activating	activate	VBG
cord-012045-1cqqj84n	433	20	NF	NF	NNP
cord-012045-1cqqj84n	433	21	-	-	HYPH
cord-012045-1cqqj84n	433	22	kappaB	kappaB	NNP
cord-012045-1cqqj84n	434	1	The	the	DT
cord-012045-1cqqj84n	434	2	role	role	NN
cord-012045-1cqqj84n	434	3	of	of	IN
cord-012045-1cqqj84n	434	4	ubiquitination	ubiquitination	NN
cord-012045-1cqqj84n	434	5	and	and	CC
cord-012045-1cqqj84n	434	6	deubiquitination	deubiquitination	NN
cord-012045-1cqqj84n	434	7	in	in	IN
cord-012045-1cqqj84n	434	8	the	the	DT
cord-012045-1cqqj84n	434	9	regulation	regulation	NN
cord-012045-1cqqj84n	434	10	of	of	IN
cord-012045-1cqqj84n	434	11	cell	cell	NN
cord-012045-1cqqj84n	434	12	junctions	junction	NNS
cord-012045-1cqqj84n	434	13	Pathological	pathological	JJ
cord-012045-1cqqj84n	434	14	findings	finding	NNS
cord-012045-1cqqj84n	434	15	of	of	IN
cord-012045-1cqqj84n	434	16	COVID-19	COVID-19	NNP
cord-012045-1cqqj84n	434	17	associated	associate	VBN
cord-012045-1cqqj84n	434	18	with	with	IN
cord-012045-1cqqj84n	434	19	acute	acute	JJ
cord-012045-1cqqj84n	434	20	respiratory	respiratory	JJ
cord-012045-1cqqj84n	434	21	distress	distress	NN
cord-012045-1cqqj84n	434	22	syndrome	syndrome	NN
cord-012045-1cqqj84n	434	23	Pulmonary	Pulmonary	NNP
cord-012045-1cqqj84n	434	24	Pathology	Pathology	NNP
cord-012045-1cqqj84n	434	25	of	of	IN
cord-012045-1cqqj84n	434	26	Early	Early	NNP
cord-012045-1cqqj84n	434	27	-	-	HYPH
cord-012045-1cqqj84n	434	28	Phase	phase	NN
cord-012045-1cqqj84n	434	29	2019	2019	CD
cord-012045-1cqqj84n	434	30	Novel	Novel	NNP
cord-012045-1cqqj84n	434	31	Coronavirus	Coronavirus	NNP
cord-012045-1cqqj84n	434	32	(	(	-LRB-
cord-012045-1cqqj84n	434	33	COVID-19	COVID-19	NNP
cord-012045-1cqqj84n	434	34	)	)	-RRB-
cord-012045-1cqqj84n	434	35	Pneumonia	pneumonia	NN
cord-012045-1cqqj84n	434	36	in	in	IN
cord-012045-1cqqj84n	434	37	Two	two	CD
cord-012045-1cqqj84n	434	38	Patients	patient	NNS
cord-012045-1cqqj84n	434	39	with	with	IN
cord-012045-1cqqj84n	434	40	Lung	Lung	NNP
cord-012045-1cqqj84n	434	41	Cancer	Cancer	NNP
cord-012045-1cqqj84n	434	42	SARS	SARS	NNP
cord-012045-1cqqj84n	434	43	-	-	HYPH
cord-012045-1cqqj84n	434	44	CoV-2	CoV-2	NNP
cord-012045-1cqqj84n	434	45	and	and	CC
cord-012045-1cqqj84n	434	46	viral	viral	JJ
cord-012045-1cqqj84n	434	47	sepsis	sepsis	NN
cord-012045-1cqqj84n	434	48	:	:	:
cord-012045-1cqqj84n	435	1	Observations	observation	NNS
cord-012045-1cqqj84n	435	2	and	and	CC
cord-012045-1cqqj84n	435	3	hypotheses	hypothesis	NNS
cord-012045-1cqqj84n	435	4	SARS	SARS	NNP
cord-012045-1cqqj84n	435	5	hCoV	hcov	ADD
cord-012045-1cqqj84n	436	1	papain	papain	NN
cord-012045-1cqqj84n	436	2	-	-	HYPH
cord-012045-1cqqj84n	436	3	like	like	JJ
cord-012045-1cqqj84n	436	4	protease	protease	NN
cord-012045-1cqqj84n	436	5	is	be	VBZ
cord-012045-1cqqj84n	436	6	a	a	DT
cord-012045-1cqqj84n	436	7	unique	unique	JJ
cord-012045-1cqqj84n	436	8	Lys48	lys48	JJ
cord-012045-1cqqj84n	436	9	linkage	linkage	NN
cord-012045-1cqqj84n	436	10	-	-	HYPH
cord-012045-1cqqj84n	436	11	specific	specific	JJ
cord-012045-1cqqj84n	436	12	di	di	FW
cord-012045-1cqqj84n	436	13	-	-	HYPH
cord-012045-1cqqj84n	436	14	distributive	distributive	JJ
cord-012045-1cqqj84n	436	15	deubiquitinating	deubiquitinating	NN
cord-012045-1cqqj84n	436	16	enzyme	enzyme	NN
cord-012045-1cqqj84n	436	17	A	a	DT
cord-012045-1cqqj84n	436	18	noncovalent	noncovalent	JJ
cord-012045-1cqqj84n	436	19	class	class	NN
cord-012045-1cqqj84n	436	20	of	of	IN
cord-012045-1cqqj84n	437	1	papain	papain	NN
cord-012045-1cqqj84n	437	2	-	-	HYPH
cord-012045-1cqqj84n	437	3	like	like	JJ
cord-012045-1cqqj84n	437	4	protease/	protease/	ADD
cord-012045-1cqqj84n	438	1	deubiquitinase	deubiquitinase	NNP
cord-012045-1cqqj84n	438	2	inhibitors	inhibitors	NNP
cord-012045-1cqqj84n	438	3	blocks	block	VBZ
cord-012045-1cqqj84n	438	4	SARS	SARS	NNP
cord-012045-1cqqj84n	438	5	virus	virus	NN
cord-012045-1cqqj84n	438	6	replication	replication	NN
cord-012045-1cqqj84n	438	7	Human	Human	NNP
cord-012045-1cqqj84n	438	8	iPSC	iPSC	NNP
cord-012045-1cqqj84n	438	9	-	-	HYPH
cord-012045-1cqqj84n	438	10	Derived	derive	VBN
cord-012045-1cqqj84n	438	11	Cardiomyocytes	Cardiomyocytes	NNPS
cord-012045-1cqqj84n	438	12	are	be	VBP
cord-012045-1cqqj84n	438	13	Susceptible	susceptible	JJ
cord-012045-1cqqj84n	438	14	to	to	IN
cord-012045-1cqqj84n	438	15	SARS	SARS	NNP
cord-012045-1cqqj84n	438	16	-	-	HYPH
cord-012045-1cqqj84n	438	17	CoV-2	CoV-2	NNP
cord-012045-1cqqj84n	438	18	Infection	Infection	NNP
cord-012045-1cqqj84n	438	19	SARS	SARS	NNP
cord-012045-1cqqj84n	438	20	-	-	HYPH
cord-012045-1cqqj84n	438	21	CoV-2	CoV-2	NNP
cord-012045-1cqqj84n	439	1	Receptor	Receptor	NNP
cord-012045-1cqqj84n	439	2	ACE2	ACE2	NNP
cord-012045-1cqqj84n	439	3	Is	be	VBZ
cord-012045-1cqqj84n	439	4	an	an	DT
cord-012045-1cqqj84n	439	5	Interferon	Interferon	NNP
cord-012045-1cqqj84n	439	6	-	-	HYPH
cord-012045-1cqqj84n	439	7	Stimulated	stimulate	VBN
cord-012045-1cqqj84n	439	8	Gene	Gene	NNP
cord-012045-1cqqj84n	439	9	in	in	IN
cord-012045-1cqqj84n	439	10	Human	Human	NNP
cord-012045-1cqqj84n	439	11	Airway	Airway	NNP
cord-012045-1cqqj84n	439	12	Epithelial	Epithelial	NNP
cord-012045-1cqqj84n	439	13	Cells	cell	NNS
cord-012045-1cqqj84n	439	14	and	and	CC
cord-012045-1cqqj84n	439	15	Is	be	VBZ
cord-012045-1cqqj84n	439	16	Detected	detect	VBN
cord-012045-1cqqj84n	439	17	in	in	IN
cord-012045-1cqqj84n	439	18	Specific	specific	JJ
cord-012045-1cqqj84n	439	19	Cell	cell	NN
cord-012045-1cqqj84n	439	20	Subsets	subset	NNS
cord-012045-1cqqj84n	439	21	across	across	IN
cord-012045-1cqqj84n	439	22	Tissues	Tissues	NNPS
cord-012045-1cqqj84n	439	23	Proteomic	Proteomic	NNP
cord-012045-1cqqj84n	439	24	and	and	CC
cord-012045-1cqqj84n	439	25	Metabolomic	Metabolomic	NNP
cord-012045-1cqqj84n	439	26	Characterization	Characterization	NNP
cord-012045-1cqqj84n	439	27	of	of	IN
cord-012045-1cqqj84n	439	28	COVID-19	COVID-19	NNP
cord-012045-1cqqj84n	439	29	Patient	Patient	NNP
cord-012045-1cqqj84n	439	30	Sera	Sera	NNP
cord-012045-1cqqj84n	439	31	Structural	structural	JJ
cord-012045-1cqqj84n	439	32	basis	basis	NN
cord-012045-1cqqj84n	439	33	of	of	IN
cord-012045-1cqqj84n	439	34	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	439	35	recognition	recognition	NN
cord-012045-1cqqj84n	439	36	by	by	IN
cord-012045-1cqqj84n	439	37	the	the	DT
cord-012045-1cqqj84n	439	38	deubiquitinating	deubiquitinating	NN
cord-012045-1cqqj84n	439	39	protease	protease	NN
cord-012045-1cqqj84n	439	40	USP2	USP2	NNP
cord-012045-1cqqj84n	439	41	.	.	.
cord-012045-1cqqj84n	440	1	Structure	Structure	NNP
cord-012045-1cqqj84n	440	2	Amino	Amino	NNP
cord-012045-1cqqj84n	440	3	-	-	HYPH
cord-012045-1cqqj84n	440	4	terminal	terminal	NN
cord-012045-1cqqj84n	440	5	dimerization	dimerization	NN
cord-012045-1cqqj84n	440	6	,	,	,
cord-012045-1cqqj84n	440	7	NRDP1-rhodanese	NRDP1-rhodanese	NNP
cord-012045-1cqqj84n	440	8	interaction	interaction	NN
cord-012045-1cqqj84n	440	9	,	,	,
cord-012045-1cqqj84n	440	10	and	and	CC
cord-012045-1cqqj84n	440	11	inhibited	inhibited	JJ
cord-012045-1cqqj84n	440	12	catalytic	catalytic	JJ
cord-012045-1cqqj84n	440	13	domain	domain	NN
cord-012045-1cqqj84n	440	14	conformation	conformation	NN
cord-012045-1cqqj84n	440	15	of	of	IN
cord-012045-1cqqj84n	440	16	the	the	DT
cord-012045-1cqqj84n	440	17	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	440	18	-	-	HYPH
cord-012045-1cqqj84n	440	19	specific	specific	JJ
cord-012045-1cqqj84n	440	20	protease	protease	NN
cord-012045-1cqqj84n	440	21	8	8	CD
cord-012045-1cqqj84n	440	22	(	(	-LRB-
cord-012045-1cqqj84n	440	23	USP8	USP8	NNP
cord-012045-1cqqj84n	440	24	)	)	-RRB-
cord-012045-1cqqj84n	440	25	Structure	structure	NN
cord-012045-1cqqj84n	440	26	and	and	CC
cord-012045-1cqqj84n	440	27	mechanisms	mechanism	NNS
cord-012045-1cqqj84n	440	28	of	of	IN
cord-012045-1cqqj84n	440	29	the	the	DT
cord-012045-1cqqj84n	440	30	proteasome	proteasome	VBN
cord-012045-1cqqj84n	440	31	-	-	HYPH
cord-012045-1cqqj84n	440	32	associated	associate	VBN
cord-012045-1cqqj84n	440	33	deubiquitinating	deubiquitinating	NN
cord-012045-1cqqj84n	440	34	enzyme	enzyme	NN
cord-012045-1cqqj84n	441	1	USP14	USP14	NNP
cord-012045-1cqqj84n	441	2	Identification	identification	NN
cord-012045-1cqqj84n	441	3	of	of	IN
cord-012045-1cqqj84n	441	4	the	the	DT
cord-012045-1cqqj84n	441	5	familial	familial	JJ
cord-012045-1cqqj84n	441	6	cylindromatosis	cylindromatosis	NN
cord-012045-1cqqj84n	441	7	tumour	tumour	NN
cord-012045-1cqqj84n	441	8	-	-	HYPH
cord-012045-1cqqj84n	441	9	suppressor	suppressor	NN
cord-012045-1cqqj84n	441	10	gene	gene	NN
cord-012045-1cqqj84n	442	1	CYLD	CYLD	NNP
cord-012045-1cqqj84n	442	2	:	:	:
cord-012045-1cqqj84n	443	1	A	a	DT
cord-012045-1cqqj84n	443	2	deubiquitination	deubiquitination	NN
cord-012045-1cqqj84n	443	3	enzyme	enzyme	NN
cord-012045-1cqqj84n	443	4	with	with	IN
cord-012045-1cqqj84n	443	5	multiple	multiple	JJ
cord-012045-1cqqj84n	443	6	roles	role	NNS
cord-012045-1cqqj84n	443	7	in	in	IN
cord-012045-1cqqj84n	443	8	cancer	cancer	NN
cord-012045-1cqqj84n	444	1	The	the	DT
cord-012045-1cqqj84n	444	2	tumour	tumour	NN
cord-012045-1cqqj84n	444	3	suppressor	suppressor	NN
cord-012045-1cqqj84n	444	4	CYLD	CYLD	NNP
cord-012045-1cqqj84n	444	5	negatively	negatively	RB
cord-012045-1cqqj84n	444	6	regulates	regulate	VBZ
cord-012045-1cqqj84n	444	7	NF	NF	NNP
cord-012045-1cqqj84n	444	8	-	-	HYPH
cord-012045-1cqqj84n	444	9	kappaB	kappaB	NNP
cord-012045-1cqqj84n	444	10	signalling	signal	VBG
cord-012045-1cqqj84n	444	11	by	by	IN
cord-012045-1cqqj84n	444	12	deubiquitination	deubiquitination	NN
cord-012045-1cqqj84n	444	13	CYLD	CYLD	NNP
cord-012045-1cqqj84n	445	1	is	be	VBZ
cord-012045-1cqqj84n	445	2	a	a	DT
cord-012045-1cqqj84n	445	3	deubiquitinating	deubiquitinating	NN
cord-012045-1cqqj84n	445	4	enzyme	enzyme	NN
cord-012045-1cqqj84n	445	5	that	that	WDT
cord-012045-1cqqj84n	445	6	negatively	negatively	RB
cord-012045-1cqqj84n	445	7	regulates	regulate	VBZ
cord-012045-1cqqj84n	445	8	NF	NF	NNP
cord-012045-1cqqj84n	445	9	-	-	HYPH
cord-012045-1cqqj84n	445	10	kappaB	kappaB	NNP
cord-012045-1cqqj84n	445	11	activation	activation	NN
cord-012045-1cqqj84n	445	12	by	by	IN
cord-012045-1cqqj84n	445	13	TNFR	TNFR	NNP
cord-012045-1cqqj84n	445	14	family	family	NN
cord-012045-1cqqj84n	445	15	members	member	NNS
cord-012045-1cqqj84n	445	16	NF	NF	NNP
cord-012045-1cqqj84n	445	17	-	-	HYPH
cord-012045-1cqqj84n	445	18	kappaB	kappaB	NNP
cord-012045-1cqqj84n	446	1	is	be	VBZ
cord-012045-1cqqj84n	446	2	essential	essential	JJ
cord-012045-1cqqj84n	446	3	for	for	IN
cord-012045-1cqqj84n	446	4	induction	induction	NN
cord-012045-1cqqj84n	446	5	of	of	IN
cord-012045-1cqqj84n	446	6	CYLD	CYLD	NNP
cord-012045-1cqqj84n	446	7	,	,	,
cord-012045-1cqqj84n	446	8	the	the	DT
cord-012045-1cqqj84n	446	9	negative	negative	JJ
cord-012045-1cqqj84n	446	10	regulator	regulator	NN
cord-012045-1cqqj84n	446	11	of	of	IN
cord-012045-1cqqj84n	446	12	NF	NF	NNP
cord-012045-1cqqj84n	446	13	-	-	HYPH
cord-012045-1cqqj84n	446	14	kappaB	kappaB	NNP
cord-012045-1cqqj84n	446	15	:	:	:
cord-012045-1cqqj84n	446	16	Evidence	evidence	NN
cord-012045-1cqqj84n	446	17	for	for	IN
cord-012045-1cqqj84n	446	18	a	a	DT
cord-012045-1cqqj84n	446	19	novel	novel	NN
cord-012045-1cqqj84n	447	1	inducible	inducible	JJ
cord-012045-1cqqj84n	447	2	autoregulatory	autoregulatory	NNP
cord-012045-1cqqj84n	447	3	feedback	feedback	NN
cord-012045-1cqqj84n	447	4	pathway	pathway	NN
cord-012045-1cqqj84n	447	5	CYLD	CYLD	NNP
cord-012045-1cqqj84n	447	6	is	be	VBZ
cord-012045-1cqqj84n	447	7	a	a	DT
cord-012045-1cqqj84n	447	8	crucial	crucial	JJ
cord-012045-1cqqj84n	447	9	negative	negative	JJ
cord-012045-1cqqj84n	447	10	regulator	regulator	NN
cord-012045-1cqqj84n	447	11	of	of	IN
cord-012045-1cqqj84n	447	12	innate	innate	JJ
cord-012045-1cqqj84n	447	13	immune	immune	JJ
cord-012045-1cqqj84n	447	14	response	response	NN
cord-012045-1cqqj84n	447	15	in	in	IN
cord-012045-1cqqj84n	447	16	Escherichia	Escherichia	NNP
cord-012045-1cqqj84n	447	17	coli	coli	NNS
cord-012045-1cqqj84n	447	18	pneumonia	pneumonia	NN
cord-012045-1cqqj84n	448	1	Targeting	target	VBG
cord-012045-1cqqj84n	448	2	ubiquitin	ubiquitin	JJ
cord-012045-1cqqj84n	448	3	specific	specific	JJ
cord-012045-1cqqj84n	448	4	proteases	protease	NNS
cord-012045-1cqqj84n	448	5	for	for	IN
cord-012045-1cqqj84n	448	6	drug	drug	NN
cord-012045-1cqqj84n	448	7	discovery	discovery	NN
cord-012045-1cqqj84n	448	8	Screening	screening	NN
cord-012045-1cqqj84n	448	9	of	of	IN
cord-012045-1cqqj84n	448	10	DUB	dub	NN
cord-012045-1cqqj84n	448	11	activity	activity	NN
cord-012045-1cqqj84n	448	12	and	and	CC
cord-012045-1cqqj84n	448	13	specificity	specificity	NN
cord-012045-1cqqj84n	448	14	by	by	IN
cord-012045-1cqqj84n	448	15	MALDI	MALDI	NNP
cord-012045-1cqqj84n	448	16	-	-	HYPH
cord-012045-1cqqj84n	448	17	TOF	TOF	NNP
cord-012045-1cqqj84n	448	18	mass	mass	NN
cord-012045-1cqqj84n	448	19	spectrometry	spectrometry	NN
cord-012045-1cqqj84n	448	20	Critical	critical	JJ
cord-012045-1cqqj84n	448	21	role	role	NN
cord-012045-1cqqj84n	448	22	of	of	IN
cord-012045-1cqqj84n	448	23	TRAF3	traf3	NN
cord-012045-1cqqj84n	448	24	in	in	IN
cord-012045-1cqqj84n	448	25	the	the	DT
cord-012045-1cqqj84n	448	26	Toll	Toll	NNP
cord-012045-1cqqj84n	448	27	-	-	HYPH
cord-012045-1cqqj84n	448	28	like	like	JJ
cord-012045-1cqqj84n	448	29	receptor	receptor	NN
cord-012045-1cqqj84n	448	30	-	-	HYPH
cord-012045-1cqqj84n	448	31	dependent	dependent	JJ
cord-012045-1cqqj84n	448	32	and	and	CC
cord-012045-1cqqj84n	448	33	-independent	-independent	JJ
cord-012045-1cqqj84n	448	34	antiviral	antiviral	JJ
cord-012045-1cqqj84n	448	35	response	response	NN
cord-012045-1cqqj84n	448	36	Specificity	Specificity	NNP
cord-012045-1cqqj84n	448	37	in	in	IN
cord-012045-1cqqj84n	448	38	Toll	Toll	NNP
cord-012045-1cqqj84n	448	39	-	-	HYPH
cord-012045-1cqqj84n	448	40	like	like	JJ
cord-012045-1cqqj84n	448	41	receptor	receptor	NN
cord-012045-1cqqj84n	448	42	signalling	signal	VBG
cord-012045-1cqqj84n	448	43	through	through	IN
cord-012045-1cqqj84n	448	44	distinct	distinct	JJ
cord-012045-1cqqj84n	448	45	effector	effector	NN
cord-012045-1cqqj84n	448	46	functions	function	NNS
cord-012045-1cqqj84n	448	47	of	of	IN
cord-012045-1cqqj84n	448	48	TRAF3	TRAF3	NNP
cord-012045-1cqqj84n	448	49	and	and	CC
cord-012045-1cqqj84n	448	50	TRAF6	TRAF6	NNP
cord-012045-1cqqj84n	448	51	Regulation	regulation	NN
cord-012045-1cqqj84n	448	52	of	of	IN
cord-012045-1cqqj84n	448	53	antiviral	antiviral	JJ
cord-012045-1cqqj84n	448	54	responses	response	NNS
cord-012045-1cqqj84n	448	55	by	by	IN
cord-012045-1cqqj84n	448	56	a	a	DT
cord-012045-1cqqj84n	448	57	direct	direct	JJ
cord-012045-1cqqj84n	448	58	and	and	CC
cord-012045-1cqqj84n	448	59	specific	specific	JJ
cord-012045-1cqqj84n	448	60	interaction	interaction	NN
cord-012045-1cqqj84n	448	61	between	between	IN
cord-012045-1cqqj84n	448	62	TRAF3	traf3	NN
cord-012045-1cqqj84n	448	63	and	and	CC
cord-012045-1cqqj84n	448	64	Cardif	Cardif	NNP
cord-012045-1cqqj84n	448	65	DUBA	DUBA	NNP
cord-012045-1cqqj84n	448	66	:	:	:
cord-012045-1cqqj84n	449	1	A	a	DT
cord-012045-1cqqj84n	449	2	deubiquitinase	deubiquitinase	NN
cord-012045-1cqqj84n	449	3	that	that	WDT
cord-012045-1cqqj84n	449	4	regulates	regulate	VBZ
cord-012045-1cqqj84n	449	5	type	type	NN
cord-012045-1cqqj84n	450	1	I	-PRON-	PRP
cord-012045-1cqqj84n	451	1	interferon	interferon	NN
cord-012045-1cqqj84n	451	2	production	production	NN
cord-012045-1cqqj84n	451	3	Chloroquine	Chloroquine	NNP
cord-012045-1cqqj84n	451	4	attenuates	attenuate	VBZ
cord-012045-1cqqj84n	451	5	lipopolysaccharide	lipopolysaccharide	NN
cord-012045-1cqqj84n	451	6	-	-	HYPH
cord-012045-1cqqj84n	451	7	induced	induce	VBN
cord-012045-1cqqj84n	451	8	inflammatory	inflammatory	JJ
cord-012045-1cqqj84n	451	9	responses	response	NNS
cord-012045-1cqqj84n	451	10	through	through	IN
cord-012045-1cqqj84n	451	11	upregulation	upregulation	NN
cord-012045-1cqqj84n	451	12	of	of	IN
cord-012045-1cqqj84n	451	13	USP25	USP25	NNP
cord-012045-1cqqj84n	451	14	.	.	.
cord-012045-1cqqj84n	452	1	Can	Can	MD
cord-012045-1cqqj84n	452	2	OTU	OTU	NNP
cord-012045-1cqqj84n	452	3	deubiquitinases	deubiquitinase	NNS
cord-012045-1cqqj84n	452	4	reveal	reveal	VB
cord-012045-1cqqj84n	452	5	mechanisms	mechanism	NNS
cord-012045-1cqqj84n	452	6	of	of	IN
cord-012045-1cqqj84n	452	7	linkage	linkage	NN
cord-012045-1cqqj84n	452	8	specificity	specificity	NN
cord-012045-1cqqj84n	452	9	and	and	CC
cord-012045-1cqqj84n	452	10	enable	enable	VB
cord-012045-1cqqj84n	452	11	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	452	12	chain	chain	NN
cord-012045-1cqqj84n	452	13	restriction	restriction	NN
cord-012045-1cqqj84n	452	14	analysis	analysis	NN
cord-012045-1cqqj84n	453	1	Linear	linear	JJ
cord-012045-1cqqj84n	453	2	ubiquitination	ubiquitination	NN
cord-012045-1cqqj84n	453	3	signals	signal	NNS
cord-012045-1cqqj84n	453	4	in	in	IN
cord-012045-1cqqj84n	453	5	adaptive	adaptive	JJ
cord-012045-1cqqj84n	453	6	immune	immune	JJ
cord-012045-1cqqj84n	453	7	responses	response	NNS
cord-012045-1cqqj84n	454	1	OTULIN	OTULIN	NNP
cord-012045-1cqqj84n	454	2	deficiency	deficiency	NN
cord-012045-1cqqj84n	454	3	causes	cause	VBZ
cord-012045-1cqqj84n	454	4	auto	auto	NN
cord-012045-1cqqj84n	454	5	-	-	HYPH
cord-012045-1cqqj84n	454	6	inflammatory	inflammatory	JJ
cord-012045-1cqqj84n	454	7	syndrome	syndrome	NN
cord-012045-1cqqj84n	454	8	OTUB1	otub1	NN
cord-012045-1cqqj84n	454	9	co	co	NN
cord-012045-1cqqj84n	454	10	-	-	NN
cord-012045-1cqqj84n	454	11	opts	opt	VBZ
cord-012045-1cqqj84n	454	12	Lys48-linked	lys48-linke	VBN
cord-012045-1cqqj84n	454	13	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	454	14	recognition	recognition	NN
cord-012045-1cqqj84n	454	15	to	to	TO
cord-012045-1cqqj84n	454	16	suppress	suppress	VB
cord-012045-1cqqj84n	454	17	E2	E2	NNP
cord-012045-1cqqj84n	454	18	enzyme	enzyme	NN
cord-012045-1cqqj84n	454	19	function	function	NN
cord-012045-1cqqj84n	454	20	Non	non	JJ
cord-012045-1cqqj84n	454	21	-	-	JJ
cord-012045-1cqqj84n	454	22	canonical	canonical	JJ
cord-012045-1cqqj84n	454	23	inhibition	inhibition	NN
cord-012045-1cqqj84n	454	24	of	of	IN
cord-012045-1cqqj84n	454	25	DNA	dna	NN
cord-012045-1cqqj84n	454	26	damage	damage	NN
cord-012045-1cqqj84n	454	27	-	-	HYPH
cord-012045-1cqqj84n	454	28	dependent	dependent	JJ
cord-012045-1cqqj84n	454	29	ubiquitination	ubiquitination	NN
cord-012045-1cqqj84n	454	30	by	by	IN
cord-012045-1cqqj84n	454	31	OTUB1	otub1	NN
cord-012045-1cqqj84n	454	32	Evidence	evidence	NN
cord-012045-1cqqj84n	454	33	for	for	IN
cord-012045-1cqqj84n	454	34	bidentate	bidentate	JJ
cord-012045-1cqqj84n	454	35	substrate	substrate	NN
cord-012045-1cqqj84n	454	36	binding	bind	VBG
cord-012045-1cqqj84n	454	37	as	as	IN
cord-012045-1cqqj84n	454	38	the	the	DT
cord-012045-1cqqj84n	454	39	basis	basis	NN
cord-012045-1cqqj84n	454	40	for	for	IN
cord-012045-1cqqj84n	454	41	the	the	DT
cord-012045-1cqqj84n	454	42	K48	K48	NNP
cord-012045-1cqqj84n	454	43	linkage	linkage	NN
cord-012045-1cqqj84n	454	44	specificity	specificity	NN
cord-012045-1cqqj84n	454	45	of	of	IN
cord-012045-1cqqj84n	454	46	otubain	otubain	NN
cord-012045-1cqqj84n	454	47	1	1	CD
cord-012045-1cqqj84n	455	1	The	the	DT
cord-012045-1cqqj84n	455	2	mechanism	mechanism	NN
cord-012045-1cqqj84n	455	3	of	of	IN
cord-012045-1cqqj84n	455	4	OTUB1-mediated	otub1-mediated	JJ
cord-012045-1cqqj84n	455	5	inhibition	inhibition	NN
cord-012045-1cqqj84n	455	6	of	of	IN
cord-012045-1cqqj84n	455	7	ubiquitination	ubiquitination	NNP
cord-012045-1cqqj84n	455	8	A20	A20	NNP
cord-012045-1cqqj84n	455	9	(	(	-LRB-
cord-012045-1cqqj84n	455	10	TNFAIP3	TNFAIP3	NNP
cord-012045-1cqqj84n	455	11	)	)	-RRB-
cord-012045-1cqqj84n	455	12	deficiency	deficiency	NN
cord-012045-1cqqj84n	455	13	in	in	IN
cord-012045-1cqqj84n	455	14	myeloid	myeloid	JJ
cord-012045-1cqqj84n	455	15	cells	cell	NNS
cord-012045-1cqqj84n	455	16	triggers	trigger	VBZ
cord-012045-1cqqj84n	455	17	erosive	erosive	JJ
cord-012045-1cqqj84n	455	18	polyarthritis	polyarthritis	NN
cord-012045-1cqqj84n	455	19	resembling	resemble	VBG
cord-012045-1cqqj84n	455	20	rheumatoid	rheumatoid	JJ
cord-012045-1cqqj84n	455	21	arthritis	arthritis	NN
cord-012045-1cqqj84n	455	22	Histone	Histone	NNP
cord-012045-1cqqj84n	455	23	methyltransferase	methyltransferase	NN
cord-012045-1cqqj84n	455	24	Ash1l	Ash1l	NNP
cord-012045-1cqqj84n	455	25	suppresses	suppress	VBZ
cord-012045-1cqqj84n	455	26	interleukin-6	interleukin-6	NNP
cord-012045-1cqqj84n	455	27	production	production	NN
cord-012045-1cqqj84n	455	28	and	and	CC
cord-012045-1cqqj84n	455	29	inflammatory	inflammatory	JJ
cord-012045-1cqqj84n	455	30	autoimmune	autoimmune	JJ
cord-012045-1cqqj84n	455	31	diseases	disease	NNS
cord-012045-1cqqj84n	455	32	by	by	IN
cord-012045-1cqqj84n	455	33	inducing	induce	VBG
cord-012045-1cqqj84n	455	34	the	the	DT
cord-012045-1cqqj84n	455	35	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	455	36	-	-	HYPH
cord-012045-1cqqj84n	455	37	editing	editing	NN
cord-012045-1cqqj84n	455	38	enzyme	enzyme	NN
cord-012045-1cqqj84n	455	39	A20	A20	NNP
cord-012045-1cqqj84n	455	40	Elevated	Elevated	NNP
cord-012045-1cqqj84n	455	41	A20	A20	NNP
cord-012045-1cqqj84n	455	42	contributes	contribute	VBZ
cord-012045-1cqqj84n	455	43	to	to	IN
cord-012045-1cqqj84n	455	44	age	age	NN
cord-012045-1cqqj84n	455	45	-	-	HYPH
cord-012045-1cqqj84n	455	46	dependent	dependent	JJ
cord-012045-1cqqj84n	455	47	macrophage	macrophage	NN
cord-012045-1cqqj84n	455	48	dysfunction	dysfunction	NN
cord-012045-1cqqj84n	455	49	in	in	IN
cord-012045-1cqqj84n	455	50	the	the	DT
cord-012045-1cqqj84n	455	51	lungs	lung	NNS
cord-012045-1cqqj84n	456	1	K63-specific	K63-specific	NNP
cord-012045-1cqqj84n	456	2	deubiquitination	deubiquitination	NN
cord-012045-1cqqj84n	456	3	by	by	IN
cord-012045-1cqqj84n	456	4	two	two	CD
cord-012045-1cqqj84n	456	5	JAMM	JAMM	NNP
cord-012045-1cqqj84n	456	6	/	/	SYM
cord-012045-1cqqj84n	456	7	MPN+	MPN+	NNP
cord-012045-1cqqj84n	456	8	complexes	complex	NNS
cord-012045-1cqqj84n	456	9	:	:	:
cord-012045-1cqqj84n	456	10	BRISC	BRISC	NNP
cord-012045-1cqqj84n	456	11	-	-	HYPH
cord-012045-1cqqj84n	456	12	associated	associate	VBN
cord-012045-1cqqj84n	456	13	Brcc36	Brcc36	NNP
cord-012045-1cqqj84n	456	14	and	and	CC
cord-012045-1cqqj84n	456	15	proteasomal	proteasomal	NNP
cord-012045-1cqqj84n	456	16	Poh1	Poh1	NNP
cord-012045-1cqqj84n	456	17	Structural	Structural	NNP
cord-012045-1cqqj84n	456	18	basis	basis	NN
cord-012045-1cqqj84n	456	19	for	for	IN
cord-012045-1cqqj84n	456	20	specific	specific	JJ
cord-012045-1cqqj84n	456	21	cleavage	cleavage	NN
cord-012045-1cqqj84n	456	22	of	of	IN
cord-012045-1cqqj84n	456	23	Lys	Lys	NNP
cord-012045-1cqqj84n	456	24	63-linked	63-linked	CD
cord-012045-1cqqj84n	456	25	polyubiquitin	polyubiquitin	NNP
cord-012045-1cqqj84n	456	26	chains	chain	NNS
cord-012045-1cqqj84n	456	27	Sequential	sequential	JJ
cord-012045-1cqqj84n	456	28	ubiquitination	ubiquitination	NN
cord-012045-1cqqj84n	456	29	and	and	CC
cord-012045-1cqqj84n	456	30	deubiquitination	deubiquitination	NN
cord-012045-1cqqj84n	456	31	enzymes	enzyme	NNS
cord-012045-1cqqj84n	456	32	synchronize	synchronize	VBP
cord-012045-1cqqj84n	456	33	the	the	DT
cord-012045-1cqqj84n	456	34	dual	dual	JJ
cord-012045-1cqqj84n	456	35	sensor	sensor	NN
cord-012045-1cqqj84n	456	36	and	and	CC
cord-012045-1cqqj84n	456	37	effector	effector	NN
cord-012045-1cqqj84n	456	38	functions	function	NNS
cord-012045-1cqqj84n	456	39	of	of	IN
cord-012045-1cqqj84n	456	40	TRIM21	trim21	CD
cord-012045-1cqqj84n	456	41	Activation	Activation	NNP
cord-012045-1cqqj84n	456	42	of	of	IN
cord-012045-1cqqj84n	456	43	the	the	DT
cord-012045-1cqqj84n	456	44	endosome	endosome	NN
cord-012045-1cqqj84n	456	45	-	-	HYPH
cord-012045-1cqqj84n	456	46	associated	associate	VBN
cord-012045-1cqqj84n	456	47	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	456	48	isopeptidase	isopeptidase	IN
cord-012045-1cqqj84n	456	49	AMSH	AMSH	NNP
cord-012045-1cqqj84n	456	50	by	by	IN
cord-012045-1cqqj84n	456	51	STAM	STAM	NNP
cord-012045-1cqqj84n	456	52	,	,	,
cord-012045-1cqqj84n	456	53	a	a	DT
cord-012045-1cqqj84n	456	54	component	component	NN
cord-012045-1cqqj84n	456	55	of	of	IN
cord-012045-1cqqj84n	456	56	the	the	DT
cord-012045-1cqqj84n	456	57	multivesicular	multivesicular	NNP
cord-012045-1cqqj84n	456	58	body	body	NN
cord-012045-1cqqj84n	456	59	-	-	HYPH
cord-012045-1cqqj84n	456	60	sorting	sort	VBG
cord-012045-1cqqj84n	456	61	machinery	machinery	NN
cord-012045-1cqqj84n	457	1	The	the	DT
cord-012045-1cqqj84n	457	2	Lys63-specific	lys63-specific	NN
cord-012045-1cqqj84n	457	3	deubiquitinating	deubiquitinating	NN
cord-012045-1cqqj84n	457	4	enzyme	enzyme	NN
cord-012045-1cqqj84n	457	5	BRCC36	BRCC36	NNP
cord-012045-1cqqj84n	457	6	is	be	VBZ
cord-012045-1cqqj84n	457	7	regulated	regulate	VBN
cord-012045-1cqqj84n	457	8	by	by	IN
cord-012045-1cqqj84n	457	9	two	two	CD
cord-012045-1cqqj84n	457	10	scaffold	scaffold	NN
cord-012045-1cqqj84n	457	11	proteins	protein	NNS
cord-012045-1cqqj84n	457	12	localizing	localize	VBG
cord-012045-1cqqj84n	457	13	in	in	IN
cord-012045-1cqqj84n	457	14	different	different	JJ
cord-012045-1cqqj84n	457	15	subcellular	subcellular	JJ
cord-012045-1cqqj84n	457	16	compartments	compartment	NNS
cord-012045-1cqqj84n	458	1	Up	up	IN
cord-012045-1cqqj84n	458	2	-	-	HYPH
cord-012045-1cqqj84n	458	3	regulation	regulation	NN
cord-012045-1cqqj84n	458	4	of	of	IN
cord-012045-1cqqj84n	458	5	expression	expression	NN
cord-012045-1cqqj84n	458	6	of	of	IN
cord-012045-1cqqj84n	458	7	the	the	DT
cord-012045-1cqqj84n	458	8	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	458	9	carboxyl	carboxyl	NN
cord-012045-1cqqj84n	458	10	-	-	HYPH
cord-012045-1cqqj84n	458	11	terminal	terminal	NN
cord-012045-1cqqj84n	458	12	hydrolase	hydrolase	NN
cord-012045-1cqqj84n	458	13	L1	L1	NNP
cord-012045-1cqqj84n	458	14	gene	gene	NN
cord-012045-1cqqj84n	458	15	in	in	IN
cord-012045-1cqqj84n	458	16	human	human	JJ
cord-012045-1cqqj84n	458	17	airway	airway	NN
cord-012045-1cqqj84n	458	18	epithelium	epithelium	NN
cord-012045-1cqqj84n	458	19	of	of	IN
cord-012045-1cqqj84n	458	20	cigarette	cigarette	NN
cord-012045-1cqqj84n	458	21	smokers	smoker	NNS
cord-012045-1cqqj84n	458	22	Ubiquitin	ubiquitin	IN
cord-012045-1cqqj84n	458	23	carboxyl	carboxyl	NN
cord-012045-1cqqj84n	458	24	-	-	HYPH
cord-012045-1cqqj84n	458	25	terminal	terminal	NN
cord-012045-1cqqj84n	458	26	hydrolases	hydrolase	NNS
cord-012045-1cqqj84n	458	27	:	:	:
cord-012045-1cqqj84n	459	1	Involvement	involvement	NN
cord-012045-1cqqj84n	459	2	in	in	IN
cord-012045-1cqqj84n	459	3	cancer	cancer	NN
cord-012045-1cqqj84n	459	4	progression	progression	NN
cord-012045-1cqqj84n	459	5	and	and	CC
cord-012045-1cqqj84n	459	6	clinical	clinical	JJ
cord-012045-1cqqj84n	459	7	implications	implication	NNS
cord-012045-1cqqj84n	459	8	Effect	effect	NN
cord-012045-1cqqj84n	459	9	of	of	IN
cord-012045-1cqqj84n	459	10	ubiquitin	ubiquitin	JJ
cord-012045-1cqqj84n	459	11	carboxy	carboxy	JJ
cord-012045-1cqqj84n	459	12	-	-	HYPH
cord-012045-1cqqj84n	459	13	terminal	terminal	NN
cord-012045-1cqqj84n	459	14	hydrolase	hydrolase	NN
cord-012045-1cqqj84n	459	15	37	37	CD
cord-012045-1cqqj84n	459	16	on	on	IN
cord-012045-1cqqj84n	459	17	apoptotic	apoptotic	JJ
cord-012045-1cqqj84n	459	18	in	in	IN
cord-012045-1cqqj84n	459	19	A549	a549	JJ
cord-012045-1cqqj84n	459	20	cells	cell	NNS
cord-012045-1cqqj84n	460	1	Deubiquitylating	deubiquitylate	VBG
cord-012045-1cqqj84n	460	2	enzymes	enzyme	NNS
cord-012045-1cqqj84n	460	3	and	and	CC
cord-012045-1cqqj84n	460	4	drug	drug	NN
cord-012045-1cqqj84n	460	5	discovery	discovery	NN
cord-012045-1cqqj84n	460	6	:	:	:
cord-012045-1cqqj84n	461	1	Emerging	emerge	VBG
cord-012045-1cqqj84n	461	2	opportunities	opportunity	NNS
cord-012045-1cqqj84n	461	3	Monocyte	Monocyte	NNP
cord-012045-1cqqj84n	461	4	chemotactic	chemotactic	VBD
cord-012045-1cqqj84n	461	5	protein	protein	NN
cord-012045-1cqqj84n	461	6	(	(	-LRB-
cord-012045-1cqqj84n	462	1	MCP)-1	mcp)-1	NN
cord-012045-1cqqj84n	462	2	promotes	promote	VBZ
cord-012045-1cqqj84n	462	3	angiogenesis	angiogenesis	NN
cord-012045-1cqqj84n	462	4	via	via	IN
cord-012045-1cqqj84n	462	5	a	a	DT
cord-012045-1cqqj84n	462	6	novel	novel	JJ
cord-012045-1cqqj84n	462	7	transcription	transcription	NN
cord-012045-1cqqj84n	462	8	factor	factor	NN
cord-012045-1cqqj84n	462	9	,	,	,
cord-012045-1cqqj84n	462	10	MCP-1-induced	MCP-1-induced	NNP
cord-012045-1cqqj84n	462	11	protein	protein	NN
cord-012045-1cqqj84n	462	12	(	(	-LRB-
cord-012045-1cqqj84n	462	13	MCPIP	MCPIP	NNP
cord-012045-1cqqj84n	462	14	)	)	-RRB-
cord-012045-1cqqj84n	463	1	Regulatory	regulatory	JJ
cord-012045-1cqqj84n	463	2	feedback	feedback	NN
cord-012045-1cqqj84n	463	3	loop	loop	NN
cord-012045-1cqqj84n	463	4	between	between	IN
cord-012045-1cqqj84n	463	5	NF	NF	NNP
cord-012045-1cqqj84n	463	6	-	-	HYPH
cord-012045-1cqqj84n	463	7	kappaB	kappaB	NNP
cord-012045-1cqqj84n	463	8	and	and	CC
cord-012045-1cqqj84n	463	9	MCP-1-induced	MCP-1-induced	NNP
cord-012045-1cqqj84n	463	10	protein	protein	NN
cord-012045-1cqqj84n	463	11	1	1	CD
cord-012045-1cqqj84n	463	12	RNase	RNase	NNP
cord-012045-1cqqj84n	463	13	MCPIP1	mcpip1	NN
cord-012045-1cqqj84n	463	14	negatively	negatively	RB
cord-012045-1cqqj84n	463	15	regulates	regulate	VBZ
cord-012045-1cqqj84n	463	16	toll	toll	NN
cord-012045-1cqqj84n	463	17	-	-	HYPH
cord-012045-1cqqj84n	463	18	like	like	JJ
cord-012045-1cqqj84n	463	19	receptor	receptor	NN
cord-012045-1cqqj84n	463	20	4	4	CD
cord-012045-1cqqj84n	463	21	signaling	signaling	NN
cord-012045-1cqqj84n	463	22	and	and	CC
cord-012045-1cqqj84n	463	23	protects	protect	VBZ
cord-012045-1cqqj84n	463	24	mice	mouse	NNS
cord-012045-1cqqj84n	463	25	from	from	IN
cord-012045-1cqqj84n	463	26	LPS	LPS	NNP
cord-012045-1cqqj84n	463	27	-	-	HYPH
cord-012045-1cqqj84n	463	28	induced	induce	VBN
cord-012045-1cqqj84n	463	29	septic	septic	JJ
cord-012045-1cqqj84n	463	30	shock	shock	NN
cord-012045-1cqqj84n	463	31	A	a	DT
cord-012045-1cqqj84n	463	32	novel	novel	JJ
cord-012045-1cqqj84n	463	33	CCCH	CCCH	NNS
cord-012045-1cqqj84n	463	34	-	-	HYPH
cord-012045-1cqqj84n	463	35	zinc	zinc	NN
cord-012045-1cqqj84n	463	36	finger	finger	NN
cord-012045-1cqqj84n	463	37	protein	protein	NN
cord-012045-1cqqj84n	463	38	family	family	NN
cord-012045-1cqqj84n	463	39	regulates	regulate	VBZ
cord-012045-1cqqj84n	463	40	proinflammatory	proinflammatory	JJ
cord-012045-1cqqj84n	463	41	activation	activation	NN
cord-012045-1cqqj84n	463	42	of	of	IN
cord-012045-1cqqj84n	463	43	macrophages	macrophage	NNS
cord-012045-1cqqj84n	463	44	MCP	MCP	NNP
cord-012045-1cqqj84n	463	45	-	-	HYPH
cord-012045-1cqqj84n	463	46	induced	induce	VBN
cord-012045-1cqqj84n	463	47	protein	protein	NN
cord-012045-1cqqj84n	463	48	1	1	CD
cord-012045-1cqqj84n	463	49	deubiquitinates	deubiquitinates	NNP
cord-012045-1cqqj84n	463	50	TRAF	TRAF	NNP
cord-012045-1cqqj84n	463	51	proteins	protein	NNS
cord-012045-1cqqj84n	463	52	and	and	CC
cord-012045-1cqqj84n	463	53	negatively	negatively	RB
cord-012045-1cqqj84n	463	54	regulates	regulate	VBZ
cord-012045-1cqqj84n	463	55	JNK	JNK	NNP
cord-012045-1cqqj84n	463	56	and	and	CC
cord-012045-1cqqj84n	463	57	NF	NF	NNP
cord-012045-1cqqj84n	463	58	-	-	HYPH
cord-012045-1cqqj84n	463	59	kappaB	kappaB	NNP
cord-012045-1cqqj84n	463	60	signaling	signal	VBG
cord-012045-1cqqj84n	463	61	Zc3h12a	zc3h12a	NN
cord-012045-1cqqj84n	463	62	is	be	VBZ
cord-012045-1cqqj84n	463	63	an	an	DT
cord-012045-1cqqj84n	463	64	RNase	rnase	NN
cord-012045-1cqqj84n	463	65	essential	essential	NN
cord-012045-1cqqj84n	463	66	for	for	IN
cord-012045-1cqqj84n	463	67	controlling	control	VBG
cord-012045-1cqqj84n	463	68	immune	immune	JJ
cord-012045-1cqqj84n	463	69	responses	response	NNS
cord-012045-1cqqj84n	463	70	by	by	IN
cord-012045-1cqqj84n	463	71	regulating	regulate	VBG
cord-012045-1cqqj84n	463	72	mRNA	mRNA	NNP
cord-012045-1cqqj84n	463	73	decay	decay	VB
cord-012045-1cqqj84n	463	74	MCPIP1	MCPIP1	NNP
cord-012045-1cqqj84n	464	1	ribonuclease	ribonuclease	NN
cord-012045-1cqqj84n	464	2	exhibits	exhibit	VBZ
cord-012045-1cqqj84n	464	3	broad	broad	JJ
cord-012045-1cqqj84n	464	4	-	-	HYPH
cord-012045-1cqqj84n	464	5	spectrum	spectrum	NN
cord-012045-1cqqj84n	464	6	antiviral	antiviral	JJ
cord-012045-1cqqj84n	464	7	effects	effect	NNS
cord-012045-1cqqj84n	464	8	through	through	IN
cord-012045-1cqqj84n	464	9	viral	viral	JJ
cord-012045-1cqqj84n	464	10	RNA	rna	NN
cord-012045-1cqqj84n	464	11	binding	binding	NN
cord-012045-1cqqj84n	464	12	and	and	CC
cord-012045-1cqqj84n	464	13	degradation	degradation	NN
cord-012045-1cqqj84n	464	14	The	the	DT
cord-012045-1cqqj84n	464	15	Molecular	Molecular	NNP
cord-012045-1cqqj84n	464	16	Basis	Basis	NNP
cord-012045-1cqqj84n	464	17	for	for	IN
cord-012045-1cqqj84n	464	18	Ubiquitin	Ubiquitin	NNP
cord-012045-1cqqj84n	464	19	and	and	CC
cord-012045-1cqqj84n	464	20	Ubiquitin	Ubiquitin	NNP
cord-012045-1cqqj84n	464	21	-	-	HYPH
cord-012045-1cqqj84n	464	22	like	like	JJ
cord-012045-1cqqj84n	464	23	Specificities	Specificities	NNPS
cord-012045-1cqqj84n	464	24	in	in	IN
cord-012045-1cqqj84n	464	25	Bacterial	Bacterial	NNP
cord-012045-1cqqj84n	464	26	Effector	Effector	NNP
cord-012045-1cqqj84n	464	27	Proteases	Proteases	NNP
cord-012045-1cqqj84n	464	28	Crystal	Crystal	NNP
cord-012045-1cqqj84n	464	29	structure	structure	NN
cord-012045-1cqqj84n	464	30	of	of	IN
cord-012045-1cqqj84n	464	31	the	the	DT
cord-012045-1cqqj84n	464	32	Middle	Middle	NNP
cord-012045-1cqqj84n	464	33	East	East	NNP
cord-012045-1cqqj84n	464	34	respiratory	respiratory	JJ
cord-012045-1cqqj84n	464	35	syndrome	syndrome	NN
cord-012045-1cqqj84n	464	36	coronavirus	coronavirus	NN
cord-012045-1cqqj84n	464	37	(	(	-LRB-
cord-012045-1cqqj84n	464	38	MERS	MERS	NNP
cord-012045-1cqqj84n	464	39	-	-	HYPH
cord-012045-1cqqj84n	464	40	CoV	CoV	NNP
cord-012045-1cqqj84n	464	41	)	)	-RRB-
cord-012045-1cqqj84n	465	1	papain	papain	NN
cord-012045-1cqqj84n	465	2	-	-	HYPH
cord-012045-1cqqj84n	465	3	like	like	JJ
cord-012045-1cqqj84n	465	4	protease	protease	NN
cord-012045-1cqqj84n	465	5	bound	bind	VBN
cord-012045-1cqqj84n	465	6	to	to	IN
cord-012045-1cqqj84n	465	7	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	465	8	facilitates	facilitate	VBZ
cord-012045-1cqqj84n	465	9	targeted	target	VBN
cord-012045-1cqqj84n	465	10	disruption	disruption	NN
cord-012045-1cqqj84n	465	11	of	of	IN
cord-012045-1cqqj84n	465	12	deubiquitinating	deubiquitinate	VBG
cord-012045-1cqqj84n	465	13	activity	activity	NN
cord-012045-1cqqj84n	465	14	to	to	TO
cord-012045-1cqqj84n	465	15	demonstrate	demonstrate	VB
cord-012045-1cqqj84n	465	16	its	-PRON-	PRP$
cord-012045-1cqqj84n	465	17	role	role	NN
cord-012045-1cqqj84n	465	18	in	in	IN
cord-012045-1cqqj84n	465	19	innate	innate	JJ
cord-012045-1cqqj84n	465	20	immune	immune	JJ
cord-012045-1cqqj84n	465	21	suppression	suppression	NN
cord-012045-1cqqj84n	465	22	Crystal	Crystal	NNP
cord-012045-1cqqj84n	465	23	structure	structure	NN
cord-012045-1cqqj84n	465	24	of	of	IN
cord-012045-1cqqj84n	465	25	the	the	DT
cord-012045-1cqqj84n	465	26	papain	papain	NN
cord-012045-1cqqj84n	465	27	-	-	HYPH
cord-012045-1cqqj84n	465	28	like	like	JJ
cord-012045-1cqqj84n	465	29	protease	protease	NN
cord-012045-1cqqj84n	465	30	of	of	IN
cord-012045-1cqqj84n	465	31	MERS	MERS	NNP
cord-012045-1cqqj84n	465	32	coronavirus	coronavirus	NN
cord-012045-1cqqj84n	465	33	reveals	reveal	VBZ
cord-012045-1cqqj84n	465	34	unusual	unusual	JJ
cord-012045-1cqqj84n	465	35	,	,	,
cord-012045-1cqqj84n	465	36	potentially	potentially	RB
cord-012045-1cqqj84n	465	37	druggable	druggable	JJ
cord-012045-1cqqj84n	465	38	active	active	JJ
cord-012045-1cqqj84n	465	39	-	-	HYPH
cord-012045-1cqqj84n	465	40	site	site	NN
cord-012045-1cqqj84n	465	41	features	feature	VBZ
cord-012045-1cqqj84n	465	42	Ovarian	ovarian	JJ
cord-012045-1cqqj84n	465	43	tumor	tumor	NN
cord-012045-1cqqj84n	465	44	domain	domain	NN
cord-012045-1cqqj84n	465	45	-	-	HYPH
cord-012045-1cqqj84n	465	46	containing	contain	VBG
cord-012045-1cqqj84n	465	47	viral	viral	JJ
cord-012045-1cqqj84n	465	48	proteases	protease	NNS
cord-012045-1cqqj84n	465	49	evade	evade	VBP
cord-012045-1cqqj84n	465	50	ubiquitin	ubiquitin	NN
cord-012045-1cqqj84n	465	51	-	-	:
cord-012045-1cqqj84n	465	52	and	and	CC
cord-012045-1cqqj84n	465	53	ISG15-dependent	isg15-dependent	CD
cord-012045-1cqqj84n	465	54	innate	innate	JJ
cord-012045-1cqqj84n	465	55	immune	immune	JJ
cord-012045-1cqqj84n	465	56	responses	response	NNS
cord-012045-1cqqj84n	465	57	This	this	DT
cord-012045-1cqqj84n	465	58	article	article	NN
cord-012045-1cqqj84n	465	59	is	be	VBZ
cord-012045-1cqqj84n	465	60	an	an	DT
cord-012045-1cqqj84n	465	61	open	open	JJ
cord-012045-1cqqj84n	465	62	access	access	NN
cord-012045-1cqqj84n	465	63	article	article	NN
cord-012045-1cqqj84n	465	64	distributed	distribute	VBN
cord-012045-1cqqj84n	465	65	under	under	IN
cord-012045-1cqqj84n	465	66	the	the	DT
cord-012045-1cqqj84n	465	67	terms	term	NNS
cord-012045-1cqqj84n	465	68	and	and	CC
cord-012045-1cqqj84n	465	69	conditions	condition	NNS
cord-012045-1cqqj84n	465	70	of	of	IN
cord-012045-1cqqj84n	465	71	the	the	DT
cord-012045-1cqqj84n	465	72	Creative	Creative	NNP
cord-012045-1cqqj84n	465	73	Commons	Commons	NNP
cord-012045-1cqqj84n	465	74	Attribution	Attribution	NNP
cord-012045-1cqqj84n	465	75	(	(	-LRB-
cord-012045-1cqqj84n	465	76	CC	CC	NNP
cord-012045-1cqqj84n	465	77	BY	by	IN
cord-012045-1cqqj84n	465	78	)	)	-RRB-
cord-012045-1cqqj84n	465	79	license	license	NN