id sid tid token lemma pos cord-017897-mbwm0ytg 1 1 key key NN cord-017897-mbwm0ytg 1 2 : : : cord-017897-mbwm0ytg 2 1 cord-017897-mbwm0ytg cord-017897-mbwm0ytg VBN cord-017897-mbwm0ytg 2 2 authors author NNS cord-017897-mbwm0ytg 2 3 : : : cord-017897-mbwm0ytg 2 4 Chiumello Chiumello NNP cord-017897-mbwm0ytg 2 5 , , , cord-017897-mbwm0ytg 2 6 Davide Davide NNP cord-017897-mbwm0ytg 2 7 ; ; : cord-017897-mbwm0ytg 2 8 Marino Marino NNP cord-017897-mbwm0ytg 2 9 , , , cord-017897-mbwm0ytg 2 10 Antonella Antonella NNP cord-017897-mbwm0ytg 2 11 ; ; : cord-017897-mbwm0ytg 2 12 Cammaroto Cammaroto NNP cord-017897-mbwm0ytg 2 13 , , , cord-017897-mbwm0ytg 2 14 Antonio Antonio NNP cord-017897-mbwm0ytg 2 15 title title NN cord-017897-mbwm0ytg 2 16 : : : cord-017897-mbwm0ytg 2 17 The the DT cord-017897-mbwm0ytg 2 18 Acute acute JJ cord-017897-mbwm0ytg 2 19 Respiratory respiratory JJ cord-017897-mbwm0ytg 2 20 Distress Distress NNP cord-017897-mbwm0ytg 2 21 Syndrome Syndrome NNP cord-017897-mbwm0ytg 2 22 : : : cord-017897-mbwm0ytg 2 23 Diagnosis Diagnosis NNP cord-017897-mbwm0ytg 2 24 and and CC cord-017897-mbwm0ytg 2 25 Management Management NNP cord-017897-mbwm0ytg 2 26 date date NN cord-017897-mbwm0ytg 2 27 : : : cord-017897-mbwm0ytg 2 28 2018 2018 CD cord-017897-mbwm0ytg 2 29 - - SYM cord-017897-mbwm0ytg 2 30 10 10 CD cord-017897-mbwm0ytg 2 31 - - HYPH cord-017897-mbwm0ytg 2 32 01 01 CD cord-017897-mbwm0ytg 2 33 journal journal NN cord-017897-mbwm0ytg 2 34 : : : cord-017897-mbwm0ytg 2 35 Practical Practical NNP cord-017897-mbwm0ytg 2 36 Trends Trends NNPS cord-017897-mbwm0ytg 2 37 in in IN cord-017897-mbwm0ytg 2 38 Anesthesia Anesthesia NNP cord-017897-mbwm0ytg 2 39 and and CC cord-017897-mbwm0ytg 2 40 Intensive Intensive NNP cord-017897-mbwm0ytg 2 41 Care Care NNP cord-017897-mbwm0ytg 2 42 2018 2018 CD cord-017897-mbwm0ytg 2 43 DOI doi NN cord-017897-mbwm0ytg 2 44 : : : cord-017897-mbwm0ytg 3 1 10.1007/978 10.1007/978 LS cord-017897-mbwm0ytg 3 2 - - SYM cord-017897-mbwm0ytg 3 3 3 3 CD cord-017897-mbwm0ytg 3 4 - - HYPH cord-017897-mbwm0ytg 3 5 319 319 CD cord-017897-mbwm0ytg 3 6 - - HYPH cord-017897-mbwm0ytg 3 7 94189 94189 CD cord-017897-mbwm0ytg 3 8 - - HYPH cord-017897-mbwm0ytg 3 9 9_11 9_11 CD cord-017897-mbwm0ytg 3 10 sha sha NNP cord-017897-mbwm0ytg 3 11 : : : cord-017897-mbwm0ytg 4 1 f18c0d0b4a328938289a09dc9243e094024066c3 f18c0d0b4a328938289a09dc9243e094024066c3 NNP cord-017897-mbwm0ytg 4 2 doc_id doc_id CD cord-017897-mbwm0ytg 4 3 : : : cord-017897-mbwm0ytg 4 4 17897 17897 CD cord-017897-mbwm0ytg 4 5 cord_uid cord_uid NNS cord-017897-mbwm0ytg 4 6 : : : cord-017897-mbwm0ytg 5 1 mbwm0ytg mbwm0ytg NNP cord-017897-mbwm0ytg 5 2 Acute acute JJ cord-017897-mbwm0ytg 5 3 respiratory respiratory JJ cord-017897-mbwm0ytg 5 4 distress distress NN cord-017897-mbwm0ytg 5 5 syndrome syndrome NN cord-017897-mbwm0ytg 5 6 ( ( -LRB- cord-017897-mbwm0ytg 5 7 ARDS ARDS NNP cord-017897-mbwm0ytg 5 8 ) ) -RRB- cord-017897-mbwm0ytg 5 9 is be VBZ cord-017897-mbwm0ytg 5 10 characterized characterize VBN cord-017897-mbwm0ytg 5 11 by by IN cord-017897-mbwm0ytg 5 12 a a DT cord-017897-mbwm0ytg 5 13 new new JJ cord-017897-mbwm0ytg 5 14 acute acute JJ cord-017897-mbwm0ytg 5 15 onset onset NN cord-017897-mbwm0ytg 5 16 of of IN cord-017897-mbwm0ytg 5 17 hypoxemia hypoxemia NN cord-017897-mbwm0ytg 5 18 secondary secondary JJ cord-017897-mbwm0ytg 5 19 to to IN cord-017897-mbwm0ytg 5 20 a a DT cord-017897-mbwm0ytg 5 21 pulmonary pulmonary JJ cord-017897-mbwm0ytg 5 22 edema edema NN cord-017897-mbwm0ytg 5 23 of of IN cord-017897-mbwm0ytg 5 24 non non JJ cord-017897-mbwm0ytg 5 25 - - JJ cord-017897-mbwm0ytg 5 26 cardiogenic cardiogenic JJ cord-017897-mbwm0ytg 5 27 origin origin NN cord-017897-mbwm0ytg 5 28 , , , cord-017897-mbwm0ytg 5 29 bilateral bilateral JJ cord-017897-mbwm0ytg 5 30 lung lung NN cord-017897-mbwm0ytg 5 31 opacities opacity NNS cord-017897-mbwm0ytg 5 32 and and CC cord-017897-mbwm0ytg 5 33 reduction reduction NN cord-017897-mbwm0ytg 5 34 in in IN cord-017897-mbwm0ytg 5 35 respiratory respiratory JJ cord-017897-mbwm0ytg 5 36 system system NN cord-017897-mbwm0ytg 5 37 compliance compliance NN cord-017897-mbwm0ytg 5 38 after after IN cord-017897-mbwm0ytg 5 39 an an DT cord-017897-mbwm0ytg 5 40 insult insult NN cord-017897-mbwm0ytg 5 41 direct direct JJ cord-017897-mbwm0ytg 5 42 or or CC cord-017897-mbwm0ytg 5 43 indirect indirect JJ cord-017897-mbwm0ytg 5 44 to to IN cord-017897-mbwm0ytg 5 45 lungs lung NNS cord-017897-mbwm0ytg 5 46 . . . cord-017897-mbwm0ytg 6 1 Its -PRON- PRP$ cord-017897-mbwm0ytg 6 2 first first JJ cord-017897-mbwm0ytg 6 3 description description NN cord-017897-mbwm0ytg 6 4 was be VBD cord-017897-mbwm0ytg 6 5 in in IN cord-017897-mbwm0ytg 6 6 1970s 1970s CD cord-017897-mbwm0ytg 6 7 , , , cord-017897-mbwm0ytg 6 8 and and CC cord-017897-mbwm0ytg 6 9 then then RB cord-017897-mbwm0ytg 6 10 several several JJ cord-017897-mbwm0ytg 6 11 shared share VBN cord-017897-mbwm0ytg 6 12 definitions definition NNS cord-017897-mbwm0ytg 6 13 tried try VBD cord-017897-mbwm0ytg 6 14 to to TO cord-017897-mbwm0ytg 6 15 describe describe VB cord-017897-mbwm0ytg 6 16 this this DT cord-017897-mbwm0ytg 6 17 clinical clinical JJ cord-017897-mbwm0ytg 6 18 entity entity NN cord-017897-mbwm0ytg 6 19 ; ; : cord-017897-mbwm0ytg 6 20 the the DT cord-017897-mbwm0ytg 6 21 last last JJ cord-017897-mbwm0ytg 6 22 one one NN cord-017897-mbwm0ytg 6 23 , , , cord-017897-mbwm0ytg 6 24 known know VBN cord-017897-mbwm0ytg 6 25 as as IN cord-017897-mbwm0ytg 6 26 Berlin Berlin NNP cord-017897-mbwm0ytg 6 27 definition definition NN cord-017897-mbwm0ytg 6 28 , , , cord-017897-mbwm0ytg 6 29 brought bring VBD cord-017897-mbwm0ytg 6 30 an an DT cord-017897-mbwm0ytg 6 31 improvement improvement NN cord-017897-mbwm0ytg 6 32 in in IN cord-017897-mbwm0ytg 6 33 predictive predictive JJ cord-017897-mbwm0ytg 6 34 ability ability NN cord-017897-mbwm0ytg 6 35 for for IN cord-017897-mbwm0ytg 6 36 mortality mortality NN cord-017897-mbwm0ytg 6 37 . . . cord-017897-mbwm0ytg 7 1 In in IN cord-017897-mbwm0ytg 7 2 the the DT cord-017897-mbwm0ytg 7 3 present present JJ cord-017897-mbwm0ytg 7 4 chapter chapter NN cord-017897-mbwm0ytg 7 5 , , , cord-017897-mbwm0ytg 7 6 the the DT cord-017897-mbwm0ytg 7 7 diagnostic diagnostic JJ cord-017897-mbwm0ytg 7 8 workup workup NN cord-017897-mbwm0ytg 7 9 of of IN cord-017897-mbwm0ytg 7 10 the the DT cord-017897-mbwm0ytg 7 11 syndrome syndrome NN cord-017897-mbwm0ytg 7 12 will will MD cord-017897-mbwm0ytg 7 13 be be VB cord-017897-mbwm0ytg 7 14 presented present VBN cord-017897-mbwm0ytg 7 15 with with IN cord-017897-mbwm0ytg 7 16 particular particular JJ cord-017897-mbwm0ytg 7 17 attention attention NN cord-017897-mbwm0ytg 7 18 to to IN cord-017897-mbwm0ytg 7 19 microbiological microbiological JJ cord-017897-mbwm0ytg 7 20 investigations investigation NNS cord-017897-mbwm0ytg 7 21 which which WDT cord-017897-mbwm0ytg 7 22 represent represent VBP cord-017897-mbwm0ytg 7 23 a a DT cord-017897-mbwm0ytg 7 24 milestone milestone NN cord-017897-mbwm0ytg 7 25 in in IN cord-017897-mbwm0ytg 7 26 the the DT cord-017897-mbwm0ytg 7 27 diagnostic diagnostic JJ cord-017897-mbwm0ytg 7 28 process process NN cord-017897-mbwm0ytg 7 29 and and CC cord-017897-mbwm0ytg 7 30 to to IN cord-017897-mbwm0ytg 7 31 imaging imaging NN cord-017897-mbwm0ytg 7 32 techniques technique NNS cord-017897-mbwm0ytg 7 33 such such JJ cord-017897-mbwm0ytg 7 34 as as IN cord-017897-mbwm0ytg 7 35 CT CT NNP cord-017897-mbwm0ytg 7 36 scan scan NN cord-017897-mbwm0ytg 7 37 and and CC cord-017897-mbwm0ytg 7 38 lung lung NN cord-017897-mbwm0ytg 7 39 ultrasound ultrasound NN cord-017897-mbwm0ytg 7 40 . . . cord-017897-mbwm0ytg 8 1 Despite despite IN cord-017897-mbwm0ytg 8 2 the the DT cord-017897-mbwm0ytg 8 3 treatment treatment NN cord-017897-mbwm0ytg 8 4 is be VBZ cord-017897-mbwm0ytg 8 5 mainly mainly RB cord-017897-mbwm0ytg 8 6 based base VBN cord-017897-mbwm0ytg 8 7 on on IN cord-017897-mbwm0ytg 8 8 supportive supportive JJ cord-017897-mbwm0ytg 8 9 strategies strategy NNS cord-017897-mbwm0ytg 8 10 , , , cord-017897-mbwm0ytg 8 11 attention attention NN cord-017897-mbwm0ytg 8 12 should should MD cord-017897-mbwm0ytg 8 13 be be VB cord-017897-mbwm0ytg 8 14 applied apply VBN cord-017897-mbwm0ytg 8 15 to to TO cord-017897-mbwm0ytg 8 16 assure assure VB cord-017897-mbwm0ytg 8 17 adequate adequate JJ cord-017897-mbwm0ytg 8 18 respiratory respiratory JJ cord-017897-mbwm0ytg 8 19 gas gas NN cord-017897-mbwm0ytg 8 20 exchange exchange NN cord-017897-mbwm0ytg 8 21 while while IN cord-017897-mbwm0ytg 8 22 minimizing minimize VBG cord-017897-mbwm0ytg 8 23 the the DT cord-017897-mbwm0ytg 8 24 risk risk NN cord-017897-mbwm0ytg 8 25 of of IN cord-017897-mbwm0ytg 8 26 ventilator ventilator NN cord-017897-mbwm0ytg 8 27 - - HYPH cord-017897-mbwm0ytg 8 28 induced induce VBN cord-017897-mbwm0ytg 8 29 lung lung NN cord-017897-mbwm0ytg 8 30 injury injury NN cord-017897-mbwm0ytg 8 31 ( ( -LRB- cord-017897-mbwm0ytg 8 32 VILI VILI NNP cord-017897-mbwm0ytg 8 33 ) ) -RRB- cord-017897-mbwm0ytg 8 34 onset onset NN cord-017897-mbwm0ytg 8 35 . . . cord-017897-mbwm0ytg 9 1 Therefore therefore RB cord-017897-mbwm0ytg 9 2 will will MD cord-017897-mbwm0ytg 9 3 be be VB cord-017897-mbwm0ytg 9 4 described describe VBN cord-017897-mbwm0ytg 9 5 several several JJ cord-017897-mbwm0ytg 9 6 therapeutic therapeutic JJ cord-017897-mbwm0ytg 9 7 approaches approach NNS cord-017897-mbwm0ytg 9 8 to to IN cord-017897-mbwm0ytg 9 9 ARDS ARDS NNP cord-017897-mbwm0ytg 9 10 , , , cord-017897-mbwm0ytg 9 11 including include VBG cord-017897-mbwm0ytg 9 12 noninvasive noninvasive JJ cord-017897-mbwm0ytg 9 13 mechanical mechanical JJ cord-017897-mbwm0ytg 9 14 ventilation ventilation NN cord-017897-mbwm0ytg 9 15 ( ( -LRB- cord-017897-mbwm0ytg 9 16 NIMV NIMV NNP cord-017897-mbwm0ytg 9 17 ) ) -RRB- cord-017897-mbwm0ytg 9 18 , , , cord-017897-mbwm0ytg 9 19 high high JJ cord-017897-mbwm0ytg 9 20 - - HYPH cord-017897-mbwm0ytg 9 21 flow flow NN cord-017897-mbwm0ytg 9 22 nasal nasal NN cord-017897-mbwm0ytg 9 23 cannulas cannula NNS cord-017897-mbwm0ytg 9 24 ( ( -LRB- cord-017897-mbwm0ytg 9 25 HFNC HFNC NNP cord-017897-mbwm0ytg 9 26 ) ) -RRB- cord-017897-mbwm0ytg 9 27 and and CC cord-017897-mbwm0ytg 9 28 invasive invasive JJ cord-017897-mbwm0ytg 9 29 ventilation ventilation NN cord-017897-mbwm0ytg 9 30 with with IN cord-017897-mbwm0ytg 9 31 particular particular JJ cord-017897-mbwm0ytg 9 32 emphasis emphasis NN cord-017897-mbwm0ytg 9 33 to to IN cord-017897-mbwm0ytg 9 34 risks risk NNS cord-017897-mbwm0ytg 9 35 and and CC cord-017897-mbwm0ytg 9 36 benefits benefit NNS cord-017897-mbwm0ytg 9 37 of of IN cord-017897-mbwm0ytg 9 38 mechanical mechanical JJ cord-017897-mbwm0ytg 9 39 ventilation ventilation NN cord-017897-mbwm0ytg 9 40 , , , cord-017897-mbwm0ytg 9 41 PEEP peep NN cord-017897-mbwm0ytg 9 42 optimization optimization NN cord-017897-mbwm0ytg 9 43 and and CC cord-017897-mbwm0ytg 9 44 lung lung NN cord-017897-mbwm0ytg 9 45 protective protective JJ cord-017897-mbwm0ytg 9 46 ventilation ventilation NN cord-017897-mbwm0ytg 9 47 strategies strategy NNS cord-017897-mbwm0ytg 9 48 . . . cord-017897-mbwm0ytg 10 1 Rescue rescue NN cord-017897-mbwm0ytg 10 2 techniques technique NNS cord-017897-mbwm0ytg 10 3 , , , cord-017897-mbwm0ytg 10 4 such such JJ cord-017897-mbwm0ytg 10 5 as as IN cord-017897-mbwm0ytg 10 6 permissive permissive JJ cord-017897-mbwm0ytg 10 7 hypercapnia hypercapnia NN cord-017897-mbwm0ytg 10 8 , , , cord-017897-mbwm0ytg 10 9 prone prone JJ cord-017897-mbwm0ytg 10 10 positioning positioning NN cord-017897-mbwm0ytg 10 11 , , , cord-017897-mbwm0ytg 10 12 neuromuscular neuromuscular NN cord-017897-mbwm0ytg 10 13 blockade blockade NN cord-017897-mbwm0ytg 10 14 , , , cord-017897-mbwm0ytg 10 15 inhaled inhale VBN cord-017897-mbwm0ytg 10 16 vasodilators vasodilator NNS cord-017897-mbwm0ytg 10 17 , , , cord-017897-mbwm0ytg 10 18 corticosteroids corticosteroid NNS cord-017897-mbwm0ytg 10 19 , , , cord-017897-mbwm0ytg 10 20 recruitment recruitment NN cord-017897-mbwm0ytg 10 21 maneuvers maneuver NNS cord-017897-mbwm0ytg 10 22 and and CC cord-017897-mbwm0ytg 10 23 extracorporeal extracorporeal JJ cord-017897-mbwm0ytg 10 24 life life NN cord-017897-mbwm0ytg 10 25 support support NN cord-017897-mbwm0ytg 10 26 , , , cord-017897-mbwm0ytg 10 27 will will MD cord-017897-mbwm0ytg 10 28 also also RB cord-017897-mbwm0ytg 10 29 be be VB cord-017897-mbwm0ytg 10 30 reviewed review VBN cord-017897-mbwm0ytg 10 31 . . . cord-017897-mbwm0ytg 11 1 Finally finally RB cord-017897-mbwm0ytg 11 2 , , , cord-017897-mbwm0ytg 11 3 the the DT cord-017897-mbwm0ytg 11 4 chapter chapter NN cord-017897-mbwm0ytg 11 5 will will MD cord-017897-mbwm0ytg 11 6 deal deal VB cord-017897-mbwm0ytg 11 7 with with IN cord-017897-mbwm0ytg 11 8 the the DT cord-017897-mbwm0ytg 11 9 mechanical mechanical JJ cord-017897-mbwm0ytg 11 10 ventilation ventilation NN cord-017897-mbwm0ytg 11 11 weaning weaning NN cord-017897-mbwm0ytg 11 12 process process NN cord-017897-mbwm0ytg 11 13 with with IN cord-017897-mbwm0ytg 11 14 particular particular JJ cord-017897-mbwm0ytg 11 15 emphasis emphasis NN cord-017897-mbwm0ytg 11 16 on on IN cord-017897-mbwm0ytg 11 17 extrapulmonary extrapulmonary JJ cord-017897-mbwm0ytg 11 18 factors factor NNS cord-017897-mbwm0ytg 11 19 such such JJ cord-017897-mbwm0ytg 11 20 as as IN cord-017897-mbwm0ytg 11 21 neurologic neurologic JJ cord-017897-mbwm0ytg 11 22 , , , cord-017897-mbwm0ytg 11 23 diaphragmatic diaphragmatic JJ cord-017897-mbwm0ytg 11 24 or or CC cord-017897-mbwm0ytg 11 25 cardiovascular cardiovascular JJ cord-017897-mbwm0ytg 11 26 alterations alteration NNS cord-017897-mbwm0ytg 11 27 which which WDT cord-017897-mbwm0ytg 11 28 can can MD cord-017897-mbwm0ytg 11 29 lead lead VB cord-017897-mbwm0ytg 11 30 to to IN cord-017897-mbwm0ytg 11 31 weaning wean VBG cord-017897-mbwm0ytg 11 32 failure failure NN cord-017897-mbwm0ytg 11 33 . . . cord-017897-mbwm0ytg 12 1 The the DT cord-017897-mbwm0ytg 12 2 first first JJ cord-017897-mbwm0ytg 12 3 of of IN cord-017897-mbwm0ytg 12 4 the the DT cord-017897-mbwm0ytg 12 5 acute acute JJ cord-017897-mbwm0ytg 12 6 respiratory respiratory JJ cord-017897-mbwm0ytg 12 7 distress distress NN cord-017897-mbwm0ytg 12 8 syndrome syndrome NN cord-017897-mbwm0ytg 12 9 ( ( -LRB- cord-017897-mbwm0ytg 12 10 ARDS ARDS NNP cord-017897-mbwm0ytg 12 11 ) ) -RRB- cord-017897-mbwm0ytg 12 12 description description NN cord-017897-mbwm0ytg 12 13 was be VBD cord-017897-mbwm0ytg 12 14 in in IN cord-017897-mbwm0ytg 12 15 1821 1821 CD cord-017897-mbwm0ytg 12 16 by by IN cord-017897-mbwm0ytg 12 17 Laennec Laennec NNP cord-017897-mbwm0ytg 12 18 . . . cord-017897-mbwm0ytg 13 1 Since since IN cord-017897-mbwm0ytg 13 2 that that DT cord-017897-mbwm0ytg 13 3 many many JJ cord-017897-mbwm0ytg 13 4 and and CC cord-017897-mbwm0ytg 13 5 more more RBR cord-017897-mbwm0ytg 13 6 accurate accurate JJ cord-017897-mbwm0ytg 13 7 definitions definition NNS cord-017897-mbwm0ytg 13 8 followed follow VBN cord-017897-mbwm0ytg 13 9 . . . cord-017897-mbwm0ytg 14 1 Nowadays nowadays RB cord-017897-mbwm0ytg 14 2 almost almost RB cord-017897-mbwm0ytg 14 3 5 5 CD cord-017897-mbwm0ytg 14 4 % % NN cord-017897-mbwm0ytg 14 5 of of IN cord-017897-mbwm0ytg 14 6 hospitalized hospitalize VBN cord-017897-mbwm0ytg 14 7 and and CC cord-017897-mbwm0ytg 14 8 mechanically mechanically RB cord-017897-mbwm0ytg 14 9 ventilated ventilate VBN cord-017897-mbwm0ytg 14 10 patients patient NNS cord-017897-mbwm0ytg 14 11 present present JJ cord-017897-mbwm0ytg 14 12 ARDS ARDS NNP cord-017897-mbwm0ytg 14 13 diagnostic diagnostic JJ cord-017897-mbwm0ytg 14 14 criteria criterion NNS cord-017897-mbwm0ytg 14 15 [ [ -LRB- cord-017897-mbwm0ytg 14 16 1 1 CD cord-017897-mbwm0ytg 14 17 ] ] -RRB- cord-017897-mbwm0ytg 14 18 . . . cord-017897-mbwm0ytg 15 1 ARDS ARDS NNP cord-017897-mbwm0ytg 15 2 can can MD cord-017897-mbwm0ytg 15 3 be be VB cord-017897-mbwm0ytg 15 4 generally generally RB cord-017897-mbwm0ytg 15 5 defined define VBN cord-017897-mbwm0ytg 15 6 as as IN cord-017897-mbwm0ytg 15 7 a a DT cord-017897-mbwm0ytg 15 8 new new JJ cord-017897-mbwm0ytg 15 9 acute acute JJ cord-017897-mbwm0ytg 15 10 onset onset NN cord-017897-mbwm0ytg 15 11 of of IN cord-017897-mbwm0ytg 15 12 hypoxemia hypoxemia NN cord-017897-mbwm0ytg 15 13 and and CC cord-017897-mbwm0ytg 15 14 bilateral bilateral JJ cord-017897-mbwm0ytg 15 15 opacities opacity NNS cord-017897-mbwm0ytg 15 16 after after IN cord-017897-mbwm0ytg 15 17 an an DT cord-017897-mbwm0ytg 15 18 insult insult NN cord-017897-mbwm0ytg 15 19 direct direct JJ cord-017897-mbwm0ytg 15 20 or or CC cord-017897-mbwm0ytg 15 21 indirect indirect JJ cord-017897-mbwm0ytg 15 22 to to IN cord-017897-mbwm0ytg 15 23 the the DT cord-017897-mbwm0ytg 15 24 lungs lung NNS cord-017897-mbwm0ytg 15 25 [ [ -LRB- cord-017897-mbwm0ytg 15 26 2 2 CD cord-017897-mbwm0ytg 15 27 ] ] -RRB- cord-017897-mbwm0ytg 15 28 [ [ -LRB- cord-017897-mbwm0ytg 15 29 3 3 CD cord-017897-mbwm0ytg 15 30 ] ] -RRB- cord-017897-mbwm0ytg 15 31 [ [ -LRB- cord-017897-mbwm0ytg 15 32 4 4 CD cord-017897-mbwm0ytg 15 33 ] ] -RRB- cord-017897-mbwm0ytg 15 34 . . . cord-017897-mbwm0ytg 16 1 In in IN cord-017897-mbwm0ytg 16 2 1994 1994 CD cord-017897-mbwm0ytg 16 3 there there EX cord-017897-mbwm0ytg 16 4 was be VBD cord-017897-mbwm0ytg 16 5 the the DT cord-017897-mbwm0ytg 16 6 first first JJ cord-017897-mbwm0ytg 16 7 shared share VBN cord-017897-mbwm0ytg 16 8 definition definition NN cord-017897-mbwm0ytg 16 9 , , , cord-017897-mbwm0ytg 16 10 and and CC cord-017897-mbwm0ytg 16 11 then then RB cord-017897-mbwm0ytg 16 12 , , , cord-017897-mbwm0ytg 16 13 in in IN cord-017897-mbwm0ytg 16 14 2001 2001 CD cord-017897-mbwm0ytg 16 15 , , , cord-017897-mbwm0ytg 16 16 an an DT cord-017897-mbwm0ytg 16 17 update update NN cord-017897-mbwm0ytg 16 18 known know VBN cord-017897-mbwm0ytg 16 19 as as IN cord-017897-mbwm0ytg 16 20 " " `` cord-017897-mbwm0ytg 16 21 Berlin Berlin NNP cord-017897-mbwm0ytg 16 22 definition definition NN cord-017897-mbwm0ytg 16 23 " " '' cord-017897-mbwm0ytg 16 24 was be VBD cord-017897-mbwm0ytg 16 25 made make VBN cord-017897-mbwm0ytg 16 26 by by IN cord-017897-mbwm0ytg 16 27 an an DT cord-017897-mbwm0ytg 16 28 expert expert JJ cord-017897-mbwm0ytg 16 29 panel panel NN cord-017897-mbwm0ytg 16 30 of of IN cord-017897-mbwm0ytg 16 31 the the DT cord-017897-mbwm0ytg 16 32 European European NNP cord-017897-mbwm0ytg 16 33 Society Society NNP cord-017897-mbwm0ytg 16 34 of of IN cord-017897-mbwm0ytg 16 35 Intensive Intensive NNP cord-017897-mbwm0ytg 16 36 Care Care NNP cord-017897-mbwm0ytg 16 37 Medicine Medicine NNP cord-017897-mbwm0ytg 16 38 [ [ -LRB- cord-017897-mbwm0ytg 16 39 4 4 CD cord-017897-mbwm0ytg 16 40 ] ] -RRB- cord-017897-mbwm0ytg 16 41 . . . cord-017897-mbwm0ytg 17 1 According accord VBG cord-017897-mbwm0ytg 17 2 to to IN cord-017897-mbwm0ytg 17 3 this this DT cord-017897-mbwm0ytg 17 4 new new JJ cord-017897-mbwm0ytg 17 5 definition definition NN cord-017897-mbwm0ytg 17 6 , , , cord-017897-mbwm0ytg 17 7 ARDS ARDS NNP cord-017897-mbwm0ytg 17 8 is be VBZ cord-017897-mbwm0ytg 17 9 an an DT cord-017897-mbwm0ytg 17 10 acute acute JJ cord-017897-mbwm0ytg 17 11 form form NN cord-017897-mbwm0ytg 17 12 of of IN cord-017897-mbwm0ytg 17 13 diffuse diffuse JJ cord-017897-mbwm0ytg 17 14 lung lung NN cord-017897-mbwm0ytg 17 15 injury injury NN cord-017897-mbwm0ytg 17 16 that that WDT cord-017897-mbwm0ytg 17 17 happens happen VBZ cord-017897-mbwm0ytg 17 18 in in IN cord-017897-mbwm0ytg 17 19 patients patient NNS cord-017897-mbwm0ytg 17 20 with with IN cord-017897-mbwm0ytg 17 21 predisposing predisposing JJ cord-017897-mbwm0ytg 17 22 factors factor NNS cord-017897-mbwm0ytg 17 23 , , , cord-017897-mbwm0ytg 17 24 with with IN cord-017897-mbwm0ytg 17 25 : : : cord-017897-mbwm0ytg 17 26 -Symptoms -Symptoms . cord-017897-mbwm0ytg 17 27 onset onset NN cord-017897-mbwm0ytg 17 28 within within IN cord-017897-mbwm0ytg 17 29 1 1 CD cord-017897-mbwm0ytg 17 30 week week NN cord-017897-mbwm0ytg 17 31 of of IN cord-017897-mbwm0ytg 17 32 a a DT cord-017897-mbwm0ytg 17 33 known know VBN cord-017897-mbwm0ytg 17 34 clinical clinical JJ cord-017897-mbwm0ytg 17 35 insult insult NN cord-017897-mbwm0ytg 17 36 or or CC cord-017897-mbwm0ytg 17 37 new new JJ cord-017897-mbwm0ytg 17 38 or or CC cord-017897-mbwm0ytg 17 39 worsening worsen VBG cord-017897-mbwm0ytg 17 40 respiratory respiratory JJ cord-017897-mbwm0ytg 17 41 symptoms symptom NNS cord-017897-mbwm0ytg 18 1 -Bilateral -Bilateral JJS cord-017897-mbwm0ytg 18 2 opacities opacity NNS cord-017897-mbwm0ytg 18 3 not not RB cord-017897-mbwm0ytg 18 4 fully fully RB cord-017897-mbwm0ytg 18 5 explained explain VBN cord-017897-mbwm0ytg 18 6 by by IN cord-017897-mbwm0ytg 18 7 effusions effusion NNS cord-017897-mbwm0ytg 18 8 , , , cord-017897-mbwm0ytg 18 9 lobar lobar NNP cord-017897-mbwm0ytg 18 10 / / SYM cord-017897-mbwm0ytg 18 11 lung lung NN cord-017897-mbwm0ytg 18 12 collapse collapse NN cord-017897-mbwm0ytg 18 13 , , , cord-017897-mbwm0ytg 18 14 or or CC cord-017897-mbwm0ytg 18 15 nodules nodule NNS cord-017897-mbwm0ytg 18 16 -Respiratory -Respiratory . cord-017897-mbwm0ytg 19 1 failure failure NN cord-017897-mbwm0ytg 19 2 not not RB cord-017897-mbwm0ytg 19 3 fully fully RB cord-017897-mbwm0ytg 19 4 explained explain VBN cord-017897-mbwm0ytg 19 5 by by IN cord-017897-mbwm0ytg 19 6 cardiac cardiac JJ cord-017897-mbwm0ytg 19 7 failure failure NN cord-017897-mbwm0ytg 19 8 or or CC cord-017897-mbwm0ytg 19 9 fluid fluid JJ cord-017897-mbwm0ytg 19 10 overload overload NN cord-017897-mbwm0ytg 19 11 -Hypoxia -hypoxia NN cord-017897-mbwm0ytg 19 12 , , , cord-017897-mbwm0ytg 19 13 classified classify VBN cord-017897-mbwm0ytg 19 14 by by IN cord-017897-mbwm0ytg 19 15 PaO pao JJ cord-017897-mbwm0ytg 19 16 2 2 CD cord-017897-mbwm0ytg 19 17 /FiO /fio SYM cord-017897-mbwm0ytg 19 18 2 2 CD cord-017897-mbwm0ytg 19 19 ratio ratio NN cord-017897-mbwm0ytg 19 20 measured measure VBN cord-017897-mbwm0ytg 19 21 with with IN cord-017897-mbwm0ytg 19 22 at at RB cord-017897-mbwm0ytg 19 23 least least JJS cord-017897-mbwm0ytg 19 24 PEEP peep NN cord-017897-mbwm0ytg 19 25 of of IN cord-017897-mbwm0ytg 19 26 5 5 CD cord-017897-mbwm0ytg 19 27 cmH cmh NN cord-017897-mbwm0ytg 19 28 2 2 CD cord-017897-mbwm0ytg 19 29 O o NN cord-017897-mbwm0ytg 19 30 into into IN cord-017897-mbwm0ytg 19 31 : : : cord-017897-mbwm0ytg 19 32 mild mild JJ cord-017897-mbwm0ytg 19 33 ( ( -LRB- cord-017897-mbwm0ytg 19 34 200 200 CD cord-017897-mbwm0ytg 19 35 mmHg mmhg NN cord-017897-mbwm0ytg 19 36 ≤ ≤ NN cord-017897-mbwm0ytg 19 37 PaO PaO NNP cord-017897-mbwm0ytg 19 38 2 2 CD cord-017897-mbwm0ytg 19 39 /FiO /fio SYM cord-017897-mbwm0ytg 19 40 2 2 CD cord-017897-mbwm0ytg 19 41 ≤ ≤ NN cord-017897-mbwm0ytg 19 42 300 300 CD cord-017897-mbwm0ytg 19 43 mmHg mmHg NNPS cord-017897-mbwm0ytg 19 44 ) ) -RRB- cord-017897-mbwm0ytg 19 45 , , , cord-017897-mbwm0ytg 19 46 moderate moderate JJ cord-017897-mbwm0ytg 19 47 ( ( -LRB- cord-017897-mbwm0ytg 19 48 100 100 CD cord-017897-mbwm0ytg 19 49 mmHg mmHg NNS cord-017897-mbwm0ytg 19 50 ≤ ≤ NN cord-017897-mbwm0ytg 19 51 PaO PaO NNP cord-017897-mbwm0ytg 19 52 2 2 CD cord-017897-mbwm0ytg 19 53 / / SYM cord-017897-mbwm0ytg 19 54 FiO FiO NNP cord-017897-mbwm0ytg 19 55 2 2 CD cord-017897-mbwm0ytg 19 56 ≤ ≤ SYM cord-017897-mbwm0ytg 19 57 200 200 CD cord-017897-mbwm0ytg 19 58 mmHg mmHg NNPS cord-017897-mbwm0ytg 19 59 ) ) -RRB- cord-017897-mbwm0ytg 19 60 , , , cord-017897-mbwm0ytg 19 61 severe severe JJ cord-017897-mbwm0ytg 19 62 ( ( -LRB- cord-017897-mbwm0ytg 19 63 PaO PaO NNP cord-017897-mbwm0ytg 19 64 2 2 CD cord-017897-mbwm0ytg 19 65 /FiO /fio SYM cord-017897-mbwm0ytg 19 66 2 2 CD cord-017897-mbwm0ytg 19 67 ≤ ≤ NN cord-017897-mbwm0ytg 19 68 100 100 CD cord-017897-mbwm0ytg 19 69 mmHg mmHg NNS cord-017897-mbwm0ytg 19 70 ) ) -RRB- cord-017897-mbwm0ytg 19 71 [ [ -LRB- cord-017897-mbwm0ytg 19 72 2 2 CD cord-017897-mbwm0ytg 19 73 ] ] -RRB- cord-017897-mbwm0ytg 19 74 [ [ -LRB- cord-017897-mbwm0ytg 19 75 3 3 CD cord-017897-mbwm0ytg 19 76 ] ] -RRB- cord-017897-mbwm0ytg 19 77 [ [ -LRB- cord-017897-mbwm0ytg 19 78 4 4 CD cord-017897-mbwm0ytg 19 79 ] ] -RRB- cord-017897-mbwm0ytg 19 80 . . . cord-017897-mbwm0ytg 20 1 This this DT cord-017897-mbwm0ytg 20 2 new new JJ cord-017897-mbwm0ytg 20 3 definition definition NN cord-017897-mbwm0ytg 20 4 brings bring VBZ cord-017897-mbwm0ytg 20 5 a a DT cord-017897-mbwm0ytg 20 6 small small JJ cord-017897-mbwm0ytg 20 7 , , , cord-017897-mbwm0ytg 20 8 but but CC cord-017897-mbwm0ytg 20 9 very very RB cord-017897-mbwm0ytg 20 10 important important JJ cord-017897-mbwm0ytg 20 11 , , , cord-017897-mbwm0ytg 20 12 improvement improvement NN cord-017897-mbwm0ytg 20 13 in in IN cord-017897-mbwm0ytg 20 14 predictive predictive JJ cord-017897-mbwm0ytg 20 15 ability ability NN cord-017897-mbwm0ytg 20 16 for for IN cord-017897-mbwm0ytg 20 17 mortality mortality NN cord-017897-mbwm0ytg 21 1 ( ( -LRB- cord-017897-mbwm0ytg 21 2 Area area NN cord-017897-mbwm0ytg 21 3 Under under IN cord-017897-mbwm0ytg 21 4 the the DT cord-017897-mbwm0ytg 21 5 Curve curve NN cord-017897-mbwm0ytg 21 6 [ [ -LRB- cord-017897-mbwm0ytg 21 7 AUC AUC NNP cord-017897-mbwm0ytg 21 8 ] ] -RRB- cord-017897-mbwm0ytg 21 9 0.577 0.577 CD cord-017897-mbwm0ytg 21 10 ) ) -RRB- cord-017897-mbwm0ytg 22 1 [ [ -LRB- cord-017897-mbwm0ytg 22 2 5 5 CD cord-017897-mbwm0ytg 22 3 ] ] -RRB- cord-017897-mbwm0ytg 22 4 . . . cord-017897-mbwm0ytg 23 1 evaluate evaluate VB cord-017897-mbwm0ytg 23 2 lung lung NN cord-017897-mbwm0ytg 23 3 morphology morphology NN cord-017897-mbwm0ytg 23 4 , , , cord-017897-mbwm0ytg 23 5 which which WDT cord-017897-mbwm0ytg 23 6 in in IN cord-017897-mbwm0ytg 23 7 ARDS ARDS NNP cord-017897-mbwm0ytg 23 8 is be VBZ cord-017897-mbwm0ytg 23 9 characterized characterize VBN cord-017897-mbwm0ytg 23 10 by by IN cord-017897-mbwm0ytg 23 11 consolidated consolidated JJ cord-017897-mbwm0ytg 23 12 regions region NNS cord-017897-mbwm0ytg 23 13 ( ( -LRB- cord-017897-mbwm0ytg 23 14 homogeneous homogeneous JJ cord-017897-mbwm0ytg 23 15 areas area NNS cord-017897-mbwm0ytg 23 16 with with IN cord-017897-mbwm0ytg 23 17 increased increase VBN cord-017897-mbwm0ytg 23 18 density density NN cord-017897-mbwm0ytg 23 19 without without IN cord-017897-mbwm0ytg 23 20 identifiable identifiable JJ cord-017897-mbwm0ytg 23 21 vessels vessel NNS cord-017897-mbwm0ytg 23 22 or or CC cord-017897-mbwm0ytg 23 23 bronchi bronchi NN cord-017897-mbwm0ytg 23 24 ) ) -RRB- cord-017897-mbwm0ytg 23 25 , , , cord-017897-mbwm0ytg 23 26 ground ground NN cord-017897-mbwm0ytg 23 27 glass glass NN cord-017897-mbwm0ytg 23 28 regions region NNS cord-017897-mbwm0ytg 23 29 ( ( -LRB- cord-017897-mbwm0ytg 23 30 areas area NNS cord-017897-mbwm0ytg 23 31 with with IN cord-017897-mbwm0ytg 23 32 increased increase VBN cord-017897-mbwm0ytg 23 33 density density NN cord-017897-mbwm0ytg 23 34 but but CC cord-017897-mbwm0ytg 23 35 with with IN cord-017897-mbwm0ytg 23 36 still still RB cord-017897-mbwm0ytg 23 37 visible visible JJ cord-017897-mbwm0ytg 23 38 vessels vessel NNS cord-017897-mbwm0ytg 23 39 ) ) -RRB- cord-017897-mbwm0ytg 23 40 , , , cord-017897-mbwm0ytg 23 41 and and CC cord-017897-mbwm0ytg 23 42 normally normally RB cord-017897-mbwm0ytg 23 43 aerated aerated JJ cord-017897-mbwm0ytg 23 44 regions region NNS cord-017897-mbwm0ytg 23 45 . . . cord-017897-mbwm0ytg 24 1 Since since IN cord-017897-mbwm0ytg 24 2 lungs lung NNS cord-017897-mbwm0ytg 24 3 are be VBP cord-017897-mbwm0ytg 24 4 characterized characterize VBN cord-017897-mbwm0ytg 24 5 by by IN cord-017897-mbwm0ytg 24 6 diffuse diffuse JJ cord-017897-mbwm0ytg 24 7 edema edema NN cord-017897-mbwm0ytg 24 8 , , , cord-017897-mbwm0ytg 24 9 with with IN cord-017897-mbwm0ytg 24 10 the the DT cord-017897-mbwm0ytg 24 11 superimposed superimpose VBN cord-017897-mbwm0ytg 24 12 pressure pressure NN cord-017897-mbwm0ytg 24 13 causing cause VBG cord-017897-mbwm0ytg 24 14 atelectasis atelectasis NN cord-017897-mbwm0ytg 24 15 and and CC cord-017897-mbwm0ytg 24 16 collapse collapse NN cord-017897-mbwm0ytg 24 17 of of IN cord-017897-mbwm0ytg 24 18 dependent dependent JJ cord-017897-mbwm0ytg 24 19 lung lung NN cord-017897-mbwm0ytg 24 20 zones zone NNS cord-017897-mbwm0ytg 24 21 , , , cord-017897-mbwm0ytg 24 22 consolidated consolidated JJ cord-017897-mbwm0ytg 24 23 areas area NNS cord-017897-mbwm0ytg 24 24 are be VBP cord-017897-mbwm0ytg 24 25 typically typically RB cord-017897-mbwm0ytg 24 26 located locate VBN cord-017897-mbwm0ytg 24 27 in in IN cord-017897-mbwm0ytg 24 28 dependent dependent JJ cord-017897-mbwm0ytg 24 29 lung lung NN cord-017897-mbwm0ytg 24 30 regions region NNS cord-017897-mbwm0ytg 24 31 [ [ -LRB- cord-017897-mbwm0ytg 24 32 18 18 CD cord-017897-mbwm0ytg 24 33 ] ] -RRB- cord-017897-mbwm0ytg 24 34 . . . cord-017897-mbwm0ytg 25 1 Lung lung NN cord-017897-mbwm0ytg 25 2 CT CT NNP cord-017897-mbwm0ytg 25 3 scan scan NN cord-017897-mbwm0ytg 25 4 is be VBZ cord-017897-mbwm0ytg 25 5 also also RB cord-017897-mbwm0ytg 25 6 helpful helpful JJ cord-017897-mbwm0ytg 25 7 in in IN cord-017897-mbwm0ytg 25 8 lung lung NN cord-017897-mbwm0ytg 25 9 potential potential NN cord-017897-mbwm0ytg 25 10 of of IN cord-017897-mbwm0ytg 25 11 recruitment recruitment NN cord-017897-mbwm0ytg 25 12 evaluation evaluation NN cord-017897-mbwm0ytg 25 13 , , , cord-017897-mbwm0ytg 25 14 i.e. i.e. FW cord-017897-mbwm0ytg 25 15 , , , cord-017897-mbwm0ytg 25 16 the the DT cord-017897-mbwm0ytg 25 17 proportion proportion NN cord-017897-mbwm0ytg 25 18 of of IN cord-017897-mbwm0ytg 25 19 consolidated consolidated JJ cord-017897-mbwm0ytg 25 20 lung lung NN cord-017897-mbwm0ytg 25 21 that that WDT cord-017897-mbwm0ytg 25 22 regain regain VBP cord-017897-mbwm0ytg 25 23 aeration aeration NN cord-017897-mbwm0ytg 25 24 after after IN cord-017897-mbwm0ytg 25 25 an an DT cord-017897-mbwm0ytg 25 26 increase increase NN cord-017897-mbwm0ytg 25 27 in in IN cord-017897-mbwm0ytg 25 28 alveolar alveolar JJ cord-017897-mbwm0ytg 25 29 pressures pressure NNS cord-017897-mbwm0ytg 25 30 . . . cord-017897-mbwm0ytg 26 1 In in IN cord-017897-mbwm0ytg 26 2 ARDS ARDS NNP cord-017897-mbwm0ytg 26 3 patients patient NNS cord-017897-mbwm0ytg 26 4 , , , cord-017897-mbwm0ytg 26 5 potential potential NN cord-017897-mbwm0ytg 26 6 of of IN cord-017897-mbwm0ytg 26 7 recruitment recruitment NN cord-017897-mbwm0ytg 26 8 could could MD cord-017897-mbwm0ytg 26 9 range range VB cord-017897-mbwm0ytg 26 10 between between IN cord-017897-mbwm0ytg 26 11 0 0 CD cord-017897-mbwm0ytg 26 12 % % NN cord-017897-mbwm0ytg 26 13 and and CC cord-017897-mbwm0ytg 26 14 70 70 CD cord-017897-mbwm0ytg 26 15 % % NN cord-017897-mbwm0ytg 26 16 . . . cord-017897-mbwm0ytg 27 1 Moreover moreover RB cord-017897-mbwm0ytg 27 2 , , , cord-017897-mbwm0ytg 27 3 lung lung NN cord-017897-mbwm0ytg 27 4 CT CT NNP cord-017897-mbwm0ytg 27 5 scan scan NN cord-017897-mbwm0ytg 27 6 could could MD cord-017897-mbwm0ytg 27 7 help help VB cord-017897-mbwm0ytg 27 8 clinician clinician NN cord-017897-mbwm0ytg 27 9 in in IN cord-017897-mbwm0ytg 27 10 identifying identify VBG cord-017897-mbwm0ytg 27 11 ARDS ARDS NNP cord-017897-mbwm0ytg 27 12 etiology etiology NN cord-017897-mbwm0ytg 27 13 ; ; : cord-017897-mbwm0ytg 27 14 in in IN cord-017897-mbwm0ytg 27 15 fact fact NN cord-017897-mbwm0ytg 27 16 , , , cord-017897-mbwm0ytg 27 17 in in IN cord-017897-mbwm0ytg 27 18 pulmonary pulmonary JJ cord-017897-mbwm0ytg 27 19 ARDS ARDS NNP cord-017897-mbwm0ytg 27 20 consolidated consolidated JJ cord-017897-mbwm0ytg 27 21 and and CC cord-017897-mbwm0ytg 27 22 ground ground NN cord-017897-mbwm0ytg 27 23 glass glass NN cord-017897-mbwm0ytg 27 24 areas area NNS cord-017897-mbwm0ytg 27 25 are be VBP cord-017897-mbwm0ytg 27 26 similar similar JJ cord-017897-mbwm0ytg 27 27 , , , cord-017897-mbwm0ytg 27 28 while while IN cord-017897-mbwm0ytg 27 29 in in IN cord-017897-mbwm0ytg 27 30 extrapulmonary extrapulmonary NNP cord-017897-mbwm0ytg 27 31 ARDS ARDS NNP cord-017897-mbwm0ytg 27 32 ground ground NN cord-017897-mbwm0ytg 27 33 glass glass NN cord-017897-mbwm0ytg 27 34 areas area NNS cord-017897-mbwm0ytg 27 35 are be VBP cord-017897-mbwm0ytg 27 36 predominant predominant JJ cord-017897-mbwm0ytg 27 37 [ [ -LRB- cord-017897-mbwm0ytg 27 38 19 19 CD cord-017897-mbwm0ytg 27 39 ] ] -RRB- cord-017897-mbwm0ytg 27 40 . . . cord-017897-mbwm0ytg 28 1 Next next RB cord-017897-mbwm0ytg 28 2 to to IN cord-017897-mbwm0ytg 28 3 CT CT NNP cord-017897-mbwm0ytg 28 4 scan scan NN cord-017897-mbwm0ytg 28 5 , , , cord-017897-mbwm0ytg 28 6 ultrasound ultrasound NN cord-017897-mbwm0ytg 28 7 of of IN cord-017897-mbwm0ytg 28 8 lung lung NN cord-017897-mbwm0ytg 28 9 parenchyma parenchyma NN cord-017897-mbwm0ytg 28 10 , , , cord-017897-mbwm0ytg 28 11 pleura pleura NN cord-017897-mbwm0ytg 28 12 , , , cord-017897-mbwm0ytg 28 13 and and CC cord-017897-mbwm0ytg 28 14 air air NN cord-017897-mbwm0ytg 28 15 may may MD cord-017897-mbwm0ytg 28 16 be be VB cord-017897-mbwm0ytg 28 17 helpful helpful JJ cord-017897-mbwm0ytg 28 18 in in IN cord-017897-mbwm0ytg 28 19 diagnostic diagnostic JJ cord-017897-mbwm0ytg 28 20 evaluation evaluation NN cord-017897-mbwm0ytg 28 21 , , , cord-017897-mbwm0ytg 28 22 clinical clinical JJ cord-017897-mbwm0ytg 28 23 management management NN cord-017897-mbwm0ytg 28 24 , , , cord-017897-mbwm0ytg 28 25 and and CC cord-017897-mbwm0ytg 28 26 monitoring monitoring NN cord-017897-mbwm0ytg 28 27 of of IN cord-017897-mbwm0ytg 28 28 ARDS ARDS NNP cord-017897-mbwm0ytg 28 29 patients patient NNS cord-017897-mbwm0ytg 28 30 [ [ -LRB- cord-017897-mbwm0ytg 28 31 20 20 CD cord-017897-mbwm0ytg 28 32 ] ] -RRB- cord-017897-mbwm0ytg 28 33 [ [ -LRB- cord-017897-mbwm0ytg 28 34 21 21 CD cord-017897-mbwm0ytg 28 35 ] ] -RRB- cord-017897-mbwm0ytg 28 36 [ [ -LRB- cord-017897-mbwm0ytg 28 37 22 22 CD cord-017897-mbwm0ytg 28 38 ] ] -RRB- cord-017897-mbwm0ytg 28 39 [ [ -LRB- cord-017897-mbwm0ytg 28 40 23 23 CD cord-017897-mbwm0ytg 28 41 ] ] -RRB- cord-017897-mbwm0ytg 28 42 . . . cord-017897-mbwm0ytg 29 1 In in IN cord-017897-mbwm0ytg 29 2 respiratory respiratory JJ cord-017897-mbwm0ytg 29 3 failure failure NN cord-017897-mbwm0ytg 29 4 patients patient NNS cord-017897-mbwm0ytg 29 5 , , , cord-017897-mbwm0ytg 29 6 lung lung NN cord-017897-mbwm0ytg 29 7 ultrasound ultrasound NN cord-017897-mbwm0ytg 29 8 is be VBZ cord-017897-mbwm0ytg 29 9 characterized characterize VBN cord-017897-mbwm0ytg 29 10 mainly mainly RB cord-017897-mbwm0ytg 29 11 by by IN cord-017897-mbwm0ytg 29 12 B b NN cord-017897-mbwm0ytg 29 13 - - HYPH cord-017897-mbwm0ytg 29 14 line line NN cord-017897-mbwm0ytg 29 15 ( ( -LRB- cord-017897-mbwm0ytg 29 16 hyperechogenic hyperechogenic JJ cord-017897-mbwm0ytg 29 17 vertical vertical JJ cord-017897-mbwm0ytg 29 18 artifact artifact NN cord-017897-mbwm0ytg 29 19 line line NN cord-017897-mbwm0ytg 29 20 that that WDT cord-017897-mbwm0ytg 29 21 starts start VBZ cord-017897-mbwm0ytg 29 22 from from IN cord-017897-mbwm0ytg 29 23 pleura pleura NN cord-017897-mbwm0ytg 29 24 ) ) -RRB- cord-017897-mbwm0ytg 30 1 [ [ -LRB- cord-017897-mbwm0ytg 30 2 21 21 CD cord-017897-mbwm0ytg 30 3 ] ] -RRB- cord-017897-mbwm0ytg 30 4 , , , cord-017897-mbwm0ytg 30 5 while while IN cord-017897-mbwm0ytg 30 6 the the DT cord-017897-mbwm0ytg 30 7 B b NN cord-017897-mbwm0ytg 30 8 - - HYPH cord-017897-mbwm0ytg 30 9 pattern pattern NN cord-017897-mbwm0ytg 30 10 composed compose VBN cord-017897-mbwm0ytg 30 11 of of IN cord-017897-mbwm0ytg 30 12 three three CD cord-017897-mbwm0ytg 30 13 or or CC cord-017897-mbwm0ytg 30 14 more more JJR cord-017897-mbwm0ytg 30 15 B b NN cord-017897-mbwm0ytg 30 16 - - HYPH cord-017897-mbwm0ytg 30 17 lines line NNS cord-017897-mbwm0ytg 30 18 appears appear VBZ cord-017897-mbwm0ytg 30 19 to to TO cord-017897-mbwm0ytg 30 20 be be VB cord-017897-mbwm0ytg 30 21 correlated correlate VBN cord-017897-mbwm0ytg 30 22 with with IN cord-017897-mbwm0ytg 30 23 an an DT cord-017897-mbwm0ytg 30 24 interstitial interstitial JJ cord-017897-mbwm0ytg 30 25 pathological pathological JJ cord-017897-mbwm0ytg 30 26 process process NN cord-017897-mbwm0ytg 30 27 [ [ -LRB- cord-017897-mbwm0ytg 30 28 24 24 CD cord-017897-mbwm0ytg 30 29 ] ] -RRB- cord-017897-mbwm0ytg 30 30 . . . cord-017897-mbwm0ytg 31 1 A a DT cord-017897-mbwm0ytg 31 2 bilateral bilateral JJ cord-017897-mbwm0ytg 31 3 homogeneous homogeneous JJ cord-017897-mbwm0ytg 31 4 B b NN cord-017897-mbwm0ytg 31 5 - - HYPH cord-017897-mbwm0ytg 31 6 pattern pattern NN cord-017897-mbwm0ytg 31 7 is be VBZ cord-017897-mbwm0ytg 31 8 not not RB cord-017897-mbwm0ytg 31 9 decisive decisive JJ cord-017897-mbwm0ytg 31 10 between between IN cord-017897-mbwm0ytg 31 11 ARDS ARDS NNP cord-017897-mbwm0ytg 31 12 and and CC cord-017897-mbwm0ytg 31 13 cardiogenic cardiogenic JJ cord-017897-mbwm0ytg 31 14 edema edema NN cord-017897-mbwm0ytg 31 15 and and CC cord-017897-mbwm0ytg 31 16 deserves deserve VBZ cord-017897-mbwm0ytg 31 17 further further JJ cord-017897-mbwm0ytg 31 18 analysis analysis NN cord-017897-mbwm0ytg 31 19 [ [ -LRB- cord-017897-mbwm0ytg 31 20 25 25 CD cord-017897-mbwm0ytg 31 21 ] ] -RRB- cord-017897-mbwm0ytg 31 22 , , , cord-017897-mbwm0ytg 31 23 while while IN cord-017897-mbwm0ytg 31 24 bilateral bilateral JJ cord-017897-mbwm0ytg 31 25 , , , cord-017897-mbwm0ytg 31 26 nothomogeneous nothomogeneous JJ cord-017897-mbwm0ytg 31 27 B b NN cord-017897-mbwm0ytg 31 28 - - HYPH cord-017897-mbwm0ytg 31 29 pattern pattern NN cord-017897-mbwm0ytg 31 30 plus plus CC cord-017897-mbwm0ytg 31 31 C c NN cord-017897-mbwm0ytg 31 32 - - HYPH cord-017897-mbwm0ytg 31 33 pattern pattern NN cord-017897-mbwm0ytg 31 34 composed compose VBN cord-017897-mbwm0ytg 31 35 of of IN cord-017897-mbwm0ytg 31 36 consolidated consolidated JJ cord-017897-mbwm0ytg 31 37 areas area NNS cord-017897-mbwm0ytg 31 38 and and CC cord-017897-mbwm0ytg 31 39 pleura pleura NN cord-017897-mbwm0ytg 31 40 abnormalities abnormality NNS cord-017897-mbwm0ytg 31 41 are be VBP cord-017897-mbwm0ytg 31 42 suggestive suggestive JJ cord-017897-mbwm0ytg 31 43 of of IN cord-017897-mbwm0ytg 31 44 ARDS ARDS NNP cord-017897-mbwm0ytg 31 45 etiology etiology NN cord-017897-mbwm0ytg 31 46 [ [ -LRB- cord-017897-mbwm0ytg 31 47 26 26 CD cord-017897-mbwm0ytg 31 48 ] ] -RRB- cord-017897-mbwm0ytg 31 49 . . . cord-017897-mbwm0ytg 32 1 Figure figure NN cord-017897-mbwm0ytg 32 2 11 11 CD cord-017897-mbwm0ytg 32 3 .2 .2 NFP cord-017897-mbwm0ytg 32 4 shows show VBZ cord-017897-mbwm0ytg 32 5 possible possible JJ cord-017897-mbwm0ytg 32 6 lung lung NN cord-017897-mbwm0ytg 32 7 ultrasound ultrasound NN cord-017897-mbwm0ytg 32 8 patterns pattern NNS cord-017897-mbwm0ytg 32 9 . . . cord-017897-mbwm0ytg 33 1 The the DT cord-017897-mbwm0ytg 33 2 acute acute JJ cord-017897-mbwm0ytg 33 3 respiratory respiratory JJ cord-017897-mbwm0ytg 33 4 failure failure NN cord-017897-mbwm0ytg 33 5 management management NN cord-017897-mbwm0ytg 33 6 includes include VBZ cord-017897-mbwm0ytg 33 7 early early JJ cord-017897-mbwm0ytg 33 8 recognition recognition NN cord-017897-mbwm0ytg 33 9 of of IN cord-017897-mbwm0ytg 33 10 the the DT cord-017897-mbwm0ytg 33 11 triggering trigger VBG cord-017897-mbwm0ytg 33 12 cause cause NN cord-017897-mbwm0ytg 33 13 and and CC cord-017897-mbwm0ytg 33 14 timely timely RB cord-017897-mbwm0ytg 33 15 targeted target VBN cord-017897-mbwm0ytg 33 16 treatment treatment NN cord-017897-mbwm0ytg 33 17 . . . cord-017897-mbwm0ytg 34 1 Besides besides IN cord-017897-mbwm0ytg 34 2 that that DT cord-017897-mbwm0ytg 34 3 , , , cord-017897-mbwm0ytg 34 4 supportive supportive JJ cord-017897-mbwm0ytg 34 5 treatments treatment NNS cord-017897-mbwm0ytg 34 6 must must MD cord-017897-mbwm0ytg 34 7 be be VB cord-017897-mbwm0ytg 34 8 started start VBN cord-017897-mbwm0ytg 34 9 to to TO cord-017897-mbwm0ytg 34 10 assure assure VB cord-017897-mbwm0ytg 34 11 adequate adequate JJ cord-017897-mbwm0ytg 34 12 respiratory respiratory JJ cord-017897-mbwm0ytg 34 13 gas gas NN cord-017897-mbwm0ytg 34 14 exchange exchange NN cord-017897-mbwm0ytg 34 15 while while IN cord-017897-mbwm0ytg 34 16 minimizing minimize VBG cord-017897-mbwm0ytg 34 17 the the DT cord-017897-mbwm0ytg 34 18 risk risk NN cord-017897-mbwm0ytg 34 19 of of IN cord-017897-mbwm0ytg 34 20 ventilator ventilator NN cord-017897-mbwm0ytg 34 21 - - HYPH cord-017897-mbwm0ytg 34 22 induced induce VBN cord-017897-mbwm0ytg 34 23 lung lung NN cord-017897-mbwm0ytg 34 24 injury injury NN cord-017897-mbwm0ytg 34 25 ( ( -LRB- cord-017897-mbwm0ytg 34 26 VILI VILI NNP cord-017897-mbwm0ytg 34 27 ) ) -RRB- cord-017897-mbwm0ytg 34 28 onset onset NN cord-017897-mbwm0ytg 34 29 . . . cord-017897-mbwm0ytg 35 1 Actual actual JJ cord-017897-mbwm0ytg 35 2 knowledge knowledge NN cord-017897-mbwm0ytg 35 3 suggest suggest VBP cord-017897-mbwm0ytg 35 4 that that IN cord-017897-mbwm0ytg 35 5 in in IN cord-017897-mbwm0ytg 35 6 most most JJS cord-017897-mbwm0ytg 35 7 severe severe JJ cord-017897-mbwm0ytg 35 8 ARDS ARDS NNP cord-017897-mbwm0ytg 35 9 patients patient NNS cord-017897-mbwm0ytg 35 10 , , , cord-017897-mbwm0ytg 35 11 spontaneous spontaneous JJ cord-017897-mbwm0ytg 35 12 respiratory respiratory JJ cord-017897-mbwm0ytg 35 13 triggering triggering NN cord-017897-mbwm0ytg 35 14 could could MD cord-017897-mbwm0ytg 35 15 be be VB cord-017897-mbwm0ytg 35 16 dangerous dangerous JJ cord-017897-mbwm0ytg 35 17 ; ; : cord-017897-mbwm0ytg 35 18 thus thus RB cord-017897-mbwm0ytg 35 19 the the DT cord-017897-mbwm0ytg 35 20 spontaneous spontaneous JJ cord-017897-mbwm0ytg 35 21 breathing breathing NN cord-017897-mbwm0ytg 35 22 approach approach NN cord-017897-mbwm0ytg 35 23 should should MD cord-017897-mbwm0ytg 35 24 be be VB cord-017897-mbwm0ytg 35 25 used use VBN cord-017897-mbwm0ytg 35 26 only only RB cord-017897-mbwm0ytg 35 27 in in IN cord-017897-mbwm0ytg 35 28 mild mild JJ cord-017897-mbwm0ytg 35 29 and and CC cord-017897-mbwm0ytg 35 30 moderate moderate JJ cord-017897-mbwm0ytg 35 31 ARDS ARDS NNP cord-017897-mbwm0ytg 35 32 patients patient NNS cord-017897-mbwm0ytg 35 33 . . . cord-017897-mbwm0ytg 36 1 Different different JJ cord-017897-mbwm0ytg 36 2 therapeutic therapeutic JJ cord-017897-mbwm0ytg 36 3 targets target NNS cord-017897-mbwm0ytg 36 4 should should MD cord-017897-mbwm0ytg 36 5 be be VB cord-017897-mbwm0ytg 36 6 met meet VBN cord-017897-mbwm0ytg 36 7 using use VBG cord-017897-mbwm0ytg 36 8 different different JJ cord-017897-mbwm0ytg 36 9 pharmacological pharmacological JJ cord-017897-mbwm0ytg 36 10 and and CC cord-017897-mbwm0ytg 36 11 non non JJ cord-017897-mbwm0ytg 36 12 - - JJ cord-017897-mbwm0ytg 36 13 pharmacological pharmacological JJ cord-017897-mbwm0ytg 36 14 approaches approach NNS cord-017897-mbwm0ytg 36 15 and and CC cord-017897-mbwm0ytg 36 16 different different JJ cord-017897-mbwm0ytg 36 17 mechanical mechanical JJ cord-017897-mbwm0ytg 36 18 ventilation ventilation NN cord-017897-mbwm0ytg 36 19 modalities modality NNS cord-017897-mbwm0ytg 36 20 . . . cord-017897-mbwm0ytg 37 1 Noninvasive noninvasive JJ cord-017897-mbwm0ytg 37 2 mechanical mechanical JJ cord-017897-mbwm0ytg 37 3 ventilation ventilation NN cord-017897-mbwm0ytg 37 4 ( ( -LRB- cord-017897-mbwm0ytg 37 5 NIMV NIMV NNP cord-017897-mbwm0ytg 37 6 ) ) -RRB- cord-017897-mbwm0ytg 37 7 is be VBZ cord-017897-mbwm0ytg 37 8 able able JJ cord-017897-mbwm0ytg 37 9 to to TO cord-017897-mbwm0ytg 37 10 reduce reduce VB cord-017897-mbwm0ytg 37 11 patient patient NN cord-017897-mbwm0ytg 37 12 's 's POS cord-017897-mbwm0ytg 37 13 work work NN cord-017897-mbwm0ytg 37 14 of of IN cord-017897-mbwm0ytg 37 15 breathing breathing NN cord-017897-mbwm0ytg 37 16 and and CC cord-017897-mbwm0ytg 37 17 intrapulmonary intrapulmonary JJ cord-017897-mbwm0ytg 37 18 shunt shunt NN cord-017897-mbwm0ytg 37 19 , , , cord-017897-mbwm0ytg 37 20 improving improve VBG cord-017897-mbwm0ytg 37 21 gas gas NN cord-017897-mbwm0ytg 37 22 exchange exchange NN cord-017897-mbwm0ytg 37 23 , , , cord-017897-mbwm0ytg 37 24 avoiding avoid VBG cord-017897-mbwm0ytg 37 25 patient patient NN cord-017897-mbwm0ytg 37 26 's 's POS cord-017897-mbwm0ytg 37 27 deep deep JJ cord-017897-mbwm0ytg 37 28 sedation sedation NN cord-017897-mbwm0ytg 37 29 , , , cord-017897-mbwm0ytg 37 30 and and CC cord-017897-mbwm0ytg 37 31 reducing reduce VBG cord-017897-mbwm0ytg 37 32 the the DT cord-017897-mbwm0ytg 37 33 ventilator ventilator NN cord-017897-mbwm0ytg 37 34 - - HYPH cord-017897-mbwm0ytg 37 35 associated associate VBN cord-017897-mbwm0ytg 37 36 pneumonia pneumonia NN cord-017897-mbwm0ytg 37 37 risk risk NN cord-017897-mbwm0ytg 37 38 . . . cord-017897-mbwm0ytg 38 1 However however RB cord-017897-mbwm0ytg 38 2 , , , cord-017897-mbwm0ytg 38 3 NIMV NIMV NNP cord-017897-mbwm0ytg 38 4 use use NN cord-017897-mbwm0ytg 38 5 is be VBZ cord-017897-mbwm0ytg 38 6 widely widely RB cord-017897-mbwm0ytg 38 7 debated debate VBN cord-017897-mbwm0ytg 38 8 due due IN cord-017897-mbwm0ytg 38 9 to to IN cord-017897-mbwm0ytg 38 10 the the DT cord-017897-mbwm0ytg 38 11 high high JJ cord-017897-mbwm0ytg 38 12 risk risk NN cord-017897-mbwm0ytg 38 13 of of IN cord-017897-mbwm0ytg 38 14 failure failure NN cord-017897-mbwm0ytg 38 15 ( ( -LRB- cord-017897-mbwm0ytg 38 16 i.e. i.e. FW cord-017897-mbwm0ytg 38 17 an an DT cord-017897-mbwm0ytg 38 18 intubation intubation NN cord-017897-mbwm0ytg 38 19 rate rate NN cord-017897-mbwm0ytg 38 20 between between IN cord-017897-mbwm0ytg 38 21 30 30 CD cord-017897-mbwm0ytg 38 22 % % NN cord-017897-mbwm0ytg 38 23 and and CC cord-017897-mbwm0ytg 38 24 86 86 CD cord-017897-mbwm0ytg 38 25 % % NN cord-017897-mbwm0ytg 38 26 and and CC cord-017897-mbwm0ytg 38 27 a a DT cord-017897-mbwm0ytg 38 28 mortality mortality NN cord-017897-mbwm0ytg 38 29 rate rate NN cord-017897-mbwm0ytg 38 30 between between IN cord-017897-mbwm0ytg 38 31 15 15 CD cord-017897-mbwm0ytg 38 32 % % NN cord-017897-mbwm0ytg 38 33 and and CC cord-017897-mbwm0ytg 38 34 71 71 CD cord-017897-mbwm0ytg 38 35 % % NN cord-017897-mbwm0ytg 38 36 ) ) -RRB- cord-017897-mbwm0ytg 38 37 [ [ -LRB- cord-017897-mbwm0ytg 38 38 27 27 CD cord-017897-mbwm0ytg 38 39 ] ] -RRB- cord-017897-mbwm0ytg 38 40 , , , cord-017897-mbwm0ytg 38 41 and and CC cord-017897-mbwm0ytg 38 42 the the DT cord-017897-mbwm0ytg 38 43 consequent consequent JJ cord-017897-mbwm0ytg 38 44 risk risk NN cord-017897-mbwm0ytg 38 45 of of IN cord-017897-mbwm0ytg 38 46 delaying delay VBG cord-017897-mbwm0ytg 38 47 intubation intubation NN cord-017897-mbwm0ytg 38 48 and and CC cord-017897-mbwm0ytg 38 49 mechanical mechanical JJ cord-017897-mbwm0ytg 38 50 ventilation ventilation NN cord-017897-mbwm0ytg 38 51 in in IN cord-017897-mbwm0ytg 38 52 patients patient NNS cord-017897-mbwm0ytg 38 53 who who WP cord-017897-mbwm0ytg 38 54 fail fail VBP cord-017897-mbwm0ytg 38 55 this this DT cord-017897-mbwm0ytg 38 56 kind kind NN cord-017897-mbwm0ytg 38 57 of of IN cord-017897-mbwm0ytg 38 58 support support NN cord-017897-mbwm0ytg 38 59 . . . cord-017897-mbwm0ytg 39 1 High high JJ cord-017897-mbwm0ytg 39 2 - - HYPH cord-017897-mbwm0ytg 39 3 flow flow NN cord-017897-mbwm0ytg 39 4 nasal nasal NN cord-017897-mbwm0ytg 39 5 cannula cannula NN cord-017897-mbwm0ytg 39 6 ( ( -LRB- cord-017897-mbwm0ytg 39 7 HFNC HFNC NNP cord-017897-mbwm0ytg 39 8 ) ) -RRB- cord-017897-mbwm0ytg 39 9 represents represent VBZ cord-017897-mbwm0ytg 39 10 an an DT cord-017897-mbwm0ytg 39 11 additional additional JJ cord-017897-mbwm0ytg 39 12 noninvasive noninvasive JJ cord-017897-mbwm0ytg 39 13 ventilatory ventilatory JJ cord-017897-mbwm0ytg 39 14 support support NN cord-017897-mbwm0ytg 39 15 that that WDT cord-017897-mbwm0ytg 39 16 ensures ensure VBZ cord-017897-mbwm0ytg 39 17 patient patient NN cord-017897-mbwm0ytg 39 18 's 's POS cord-017897-mbwm0ytg 39 19 administration administration NN cord-017897-mbwm0ytg 39 20 of of IN cord-017897-mbwm0ytg 39 21 a a DT cord-017897-mbwm0ytg 39 22 heated heated JJ cord-017897-mbwm0ytg 39 23 and and CC cord-017897-mbwm0ytg 39 24 humidified humidify VBN cord-017897-mbwm0ytg 39 25 high high JJ cord-017897-mbwm0ytg 39 26 flow flow NN cord-017897-mbwm0ytg 39 27 of of IN cord-017897-mbwm0ytg 39 28 oxygen oxygen NN cord-017897-mbwm0ytg 39 29 through through IN cord-017897-mbwm0ytg 39 30 the the DT cord-017897-mbwm0ytg 39 31 patient patient NN cord-017897-mbwm0ytg 39 32 's 's POS cord-017897-mbwm0ytg 39 33 nose nose NN cord-017897-mbwm0ytg 39 34 and and CC cord-017897-mbwm0ytg 39 35 has have VBZ cord-017897-mbwm0ytg 39 36 shown show VBN cord-017897-mbwm0ytg 39 37 to to TO cord-017897-mbwm0ytg 39 38 be be VB cord-017897-mbwm0ytg 39 39 able able JJ cord-017897-mbwm0ytg 39 40 to to TO cord-017897-mbwm0ytg 39 41 reduce reduce VB cord-017897-mbwm0ytg 39 42 respiratory respiratory JJ cord-017897-mbwm0ytg 39 43 work work NN cord-017897-mbwm0ytg 39 44 while while IN cord-017897-mbwm0ytg 39 45 improving improve VBG cord-017897-mbwm0ytg 39 46 oxygenation oxygenation NN cord-017897-mbwm0ytg 39 47 and and CC cord-017897-mbwm0ytg 39 48 CO co NN cord-017897-mbwm0ytg 39 49 2 2 CD cord-017897-mbwm0ytg 39 50 elimination elimination NN cord-017897-mbwm0ytg 39 51 , , , cord-017897-mbwm0ytg 39 52 providing provide VBG cord-017897-mbwm0ytg 39 53 the the DT cord-017897-mbwm0ytg 39 54 patient patient NN cord-017897-mbwm0ytg 39 55 with with IN cord-017897-mbwm0ytg 39 56 a a DT cord-017897-mbwm0ytg 39 57 positive positive JJ cord-017897-mbwm0ytg 39 58 end end NN cord-017897-mbwm0ytg 39 59 - - HYPH cord-017897-mbwm0ytg 39 60 expiratory expiratory NN cord-017897-mbwm0ytg 39 61 pressure pressure NN cord-017897-mbwm0ytg 39 62 ( ( -LRB- cord-017897-mbwm0ytg 39 63 PEEP peep NN cord-017897-mbwm0ytg 39 64 ) ) -RRB- cord-017897-mbwm0ytg 39 65 that that WDT cord-017897-mbwm0ytg 39 66 varies vary VBZ cord-017897-mbwm0ytg 39 67 between between IN cord-017897-mbwm0ytg 39 68 4 4 CD cord-017897-mbwm0ytg 39 69 and and CC cord-017897-mbwm0ytg 39 70 6 6 CD cord-017897-mbwm0ytg 39 71 cmH cmh CD cord-017897-mbwm0ytg 39 72 2 2 CD cord-017897-mbwm0ytg 40 1 O. O. NNP cord-017897-mbwm0ytg 40 2 A a DT cord-017897-mbwm0ytg 40 3 recent recent JJ cord-017897-mbwm0ytg 40 4 study study NN cord-017897-mbwm0ytg 40 5 carried carry VBD cord-017897-mbwm0ytg 40 6 out out RP cord-017897-mbwm0ytg 40 7 on on IN cord-017897-mbwm0ytg 40 8 patients patient NNS cord-017897-mbwm0ytg 40 9 diagnosed diagnose VBN cord-017897-mbwm0ytg 40 10 with with IN cord-017897-mbwm0ytg 40 11 ARDS ARDS NNP cord-017897-mbwm0ytg 40 12 , , , cord-017897-mbwm0ytg 40 13 as as IN cord-017897-mbwm0ytg 40 14 in in IN cord-017897-mbwm0ytg 40 15 the the DT cord-017897-mbwm0ytg 40 16 case case NN cord-017897-mbwm0ytg 40 17 of of IN cord-017897-mbwm0ytg 40 18 NIV NIV NNP cord-017897-mbwm0ytg 40 19 [ [ -LRB- cord-017897-mbwm0ytg 40 20 28 28 CD cord-017897-mbwm0ytg 40 21 ] ] -RRB- cord-017897-mbwm0ytg 40 22 , , , cord-017897-mbwm0ytg 40 23 showed show VBD cord-017897-mbwm0ytg 40 24 however however RB cord-017897-mbwm0ytg 40 25 a a DT cord-017897-mbwm0ytg 40 26 high high JJ cord-017897-mbwm0ytg 40 27 rate rate NN cord-017897-mbwm0ytg 40 28 of of IN cord-017897-mbwm0ytg 40 29 HFNC HFNC NNP cord-017897-mbwm0ytg 40 30 failure failure NN cord-017897-mbwm0ytg 40 31 , , , cord-017897-mbwm0ytg 40 32 equal equal JJ cord-017897-mbwm0ytg 40 33 to to IN cord-017897-mbwm0ytg 40 34 40 40 CD cord-017897-mbwm0ytg 40 35 % % NN cord-017897-mbwm0ytg 40 36 [ [ -LRB- cord-017897-mbwm0ytg 40 37 29 29 CD cord-017897-mbwm0ytg 40 38 ] ] -RRB- cord-017897-mbwm0ytg 40 39 . . . cord-017897-mbwm0ytg 40 40 _SP cord-017897-mbwm0ytg 41 1 Invasive invasive JJ cord-017897-mbwm0ytg 41 2 mechanical mechanical JJ cord-017897-mbwm0ytg 41 3 ventilation ventilation NN cord-017897-mbwm0ytg 41 4 is be VBZ cord-017897-mbwm0ytg 41 5 a a DT cord-017897-mbwm0ytg 41 6 supportive supportive JJ cord-017897-mbwm0ytg 41 7 therapy therapy NN cord-017897-mbwm0ytg 41 8 able able JJ cord-017897-mbwm0ytg 41 9 to to TO cord-017897-mbwm0ytg 41 10 guarantee guarantee VB cord-017897-mbwm0ytg 41 11 adequate adequate JJ cord-017897-mbwm0ytg 41 12 gas gas NN cord-017897-mbwm0ytg 41 13 exchange exchange NN cord-017897-mbwm0ytg 41 14 ( ( -LRB- cord-017897-mbwm0ytg 41 15 increase increase VB cord-017897-mbwm0ytg 41 16 PaO PaO NNP cord-017897-mbwm0ytg 41 17 2 2 CD cord-017897-mbwm0ytg 41 18 and and CC cord-017897-mbwm0ytg 41 19 clear clear JJ cord-017897-mbwm0ytg 41 20 CO CO NNP cord-017897-mbwm0ytg 41 21 2 2 CD cord-017897-mbwm0ytg 41 22 adequately adequately RB cord-017897-mbwm0ytg 41 23 ) ) -RRB- cord-017897-mbwm0ytg 41 24 and and CC cord-017897-mbwm0ytg 41 25 reduce reduce VB cord-017897-mbwm0ytg 41 26 the the DT cord-017897-mbwm0ytg 41 27 respiratory respiratory JJ cord-017897-mbwm0ytg 41 28 muscle muscle NN cord-017897-mbwm0ytg 41 29 activity activity NN cord-017897-mbwm0ytg 41 30 [ [ -LRB- cord-017897-mbwm0ytg 41 31 30 30 CD cord-017897-mbwm0ytg 41 32 ] ] -RRB- cord-017897-mbwm0ytg 41 33 . . . cord-017897-mbwm0ytg 42 1 Mechanical mechanical JJ cord-017897-mbwm0ytg 42 2 ventilation ventilation NN cord-017897-mbwm0ytg 42 3 presents present VBZ cord-017897-mbwm0ytg 42 4 a a DT cord-017897-mbwm0ytg 42 5 double double JJ cord-017897-mbwm0ytg 42 6 effect effect NN cord-017897-mbwm0ytg 42 7 on on IN cord-017897-mbwm0ytg 42 8 patient patient JJ cord-017897-mbwm0ytg 42 9 oxygenation oxygenation NN cord-017897-mbwm0ytg 42 10 : : : cord-017897-mbwm0ytg 42 11 it -PRON- PRP cord-017897-mbwm0ytg 42 12 allows allow VBZ cord-017897-mbwm0ytg 42 13 a a DT cord-017897-mbwm0ytg 42 14 continuous continuous JJ cord-017897-mbwm0ytg 42 15 and and CC cord-017897-mbwm0ytg 42 16 precise precise JJ cord-017897-mbwm0ytg 42 17 FiO fio NN cord-017897-mbwm0ytg 42 18 2 2 CD cord-017897-mbwm0ytg 42 19 titration titration NN cord-017897-mbwm0ytg 42 20 and and CC cord-017897-mbwm0ytg 42 21 during during IN cord-017897-mbwm0ytg 42 22 the the DT cord-017897-mbwm0ytg 42 23 inspiratory inspiratory JJ cord-017897-mbwm0ytg 42 24 phase phase NN cord-017897-mbwm0ytg 42 25 applies apply VBZ cord-017897-mbwm0ytg 42 26 a a DT cord-017897-mbwm0ytg 42 27 positive positive JJ cord-017897-mbwm0ytg 42 28 airway airway NN cord-017897-mbwm0ytg 42 29 pressure pressure NN cord-017897-mbwm0ytg 42 30 that that WDT cord-017897-mbwm0ytg 42 31 reopens reopen VBZ cord-017897-mbwm0ytg 42 32 collapsed collapse VBN cord-017897-mbwm0ytg 42 33 alveolar alveolar JJ cord-017897-mbwm0ytg 42 34 units unit NNS cord-017897-mbwm0ytg 42 35 . . . cord-017897-mbwm0ytg 43 1 This this DT cord-017897-mbwm0ytg 43 2 second second JJ cord-017897-mbwm0ytg 43 3 effect effect NN cord-017897-mbwm0ytg 43 4 is be VBZ cord-017897-mbwm0ytg 43 5 likely likely JJ cord-017897-mbwm0ytg 43 6 to to TO cord-017897-mbwm0ytg 43 7 be be VB cord-017897-mbwm0ytg 43 8 limited limit VBN cord-017897-mbwm0ytg 43 9 in in IN cord-017897-mbwm0ytg 43 10 time time NN cord-017897-mbwm0ytg 43 11 , , , cord-017897-mbwm0ytg 43 12 unless unless IN cord-017897-mbwm0ytg 43 13 an an DT cord-017897-mbwm0ytg 43 14 adequate adequate JJ cord-017897-mbwm0ytg 43 15 positive positive JJ cord-017897-mbwm0ytg 43 16 endexpiratory endexpiratory NN cord-017897-mbwm0ytg 43 17 pressure pressure NN cord-017897-mbwm0ytg 43 18 is be VBZ cord-017897-mbwm0ytg 43 19 applied apply VBN cord-017897-mbwm0ytg 43 20 during during IN cord-017897-mbwm0ytg 43 21 the the DT cord-017897-mbwm0ytg 43 22 expiratory expiratory JJ cord-017897-mbwm0ytg 43 23 phase phase NN cord-017897-mbwm0ytg 43 24 to to TO cord-017897-mbwm0ytg 43 25 avoid avoid VB cord-017897-mbwm0ytg 43 26 the the DT cord-017897-mbwm0ytg 43 27 alveolar alveolar NNP cord-017897-mbwm0ytg 43 28 recollapse recollapse NN cord-017897-mbwm0ytg 43 29 [ [ -LRB- cord-017897-mbwm0ytg 43 30 31 31 CD cord-017897-mbwm0ytg 43 31 ] ] -RRB- cord-017897-mbwm0ytg 43 32 . . . cord-017897-mbwm0ytg 44 1 The the DT cord-017897-mbwm0ytg 44 2 ventilatory ventilatory NN cord-017897-mbwm0ytg 44 3 setting setting NN cord-017897-mbwm0ytg 44 4 in in IN cord-017897-mbwm0ytg 44 5 ARDS ARDS NNP cord-017897-mbwm0ytg 44 6 patient patient NN cord-017897-mbwm0ytg 44 7 remains remain VBZ cord-017897-mbwm0ytg 44 8 a a DT cord-017897-mbwm0ytg 44 9 daily daily JJ cord-017897-mbwm0ytg 44 10 challenge challenge NN cord-017897-mbwm0ytg 44 11 , , , cord-017897-mbwm0ytg 44 12 and and CC cord-017897-mbwm0ytg 44 13 the the DT cord-017897-mbwm0ytg 44 14 choice choice NN cord-017897-mbwm0ytg 44 15 should should MD cord-017897-mbwm0ytg 44 16 be be VB cord-017897-mbwm0ytg 44 17 adapted adapt VBN cord-017897-mbwm0ytg 44 18 to to IN cord-017897-mbwm0ytg 44 19 each each DT cord-017897-mbwm0ytg 44 20 patient patient NN cord-017897-mbwm0ytg 44 21 considering consider VBG cord-017897-mbwm0ytg 44 22 his -PRON- PRP$ cord-017897-mbwm0ytg 44 23 / / SYM cord-017897-mbwm0ytg 44 24 her -PRON- PRP$ cord-017897-mbwm0ytg 44 25 hemodynamic hemodynamic JJ cord-017897-mbwm0ytg 44 26 parameters parameter NNS cord-017897-mbwm0ytg 44 27 , , , cord-017897-mbwm0ytg 44 28 respiratory respiratory JJ cord-017897-mbwm0ytg 44 29 mechanics mechanic NNS cord-017897-mbwm0ytg 44 30 , , , cord-017897-mbwm0ytg 44 31 and and CC cord-017897-mbwm0ytg 44 32 gas gas NN cord-017897-mbwm0ytg 44 33 exchange exchange NN cord-017897-mbwm0ytg 44 34 . . . cord-017897-mbwm0ytg 45 1 During during IN cord-017897-mbwm0ytg 45 2 the the DT cord-017897-mbwm0ytg 45 3 last last JJ cord-017897-mbwm0ytg 45 4 30 30 CD cord-017897-mbwm0ytg 45 5 years year NNS cord-017897-mbwm0ytg 45 6 , , , cord-017897-mbwm0ytg 45 7 literature literature NN cord-017897-mbwm0ytg 45 8 has have VBZ cord-017897-mbwm0ytg 45 9 already already RB cord-017897-mbwm0ytg 45 10 widely widely RB cord-017897-mbwm0ytg 45 11 demonstrated demonstrate VBN cord-017897-mbwm0ytg 45 12 that that IN cord-017897-mbwm0ytg 45 13 high high JJ cord-017897-mbwm0ytg 45 14 - - HYPH cord-017897-mbwm0ytg 45 15 volume volume NN cord-017897-mbwm0ytg 45 16 / / SYM cord-017897-mbwm0ytg 45 17 high high JJ cord-017897-mbwm0ytg 45 18 - - HYPH cord-017897-mbwm0ytg 45 19 frequency frequency NN cord-017897-mbwm0ytg 45 20 ventilation ventilation NN cord-017897-mbwm0ytg 45 21 can can MD cord-017897-mbwm0ytg 45 22 damage damage VB cord-017897-mbwm0ytg 45 23 the the DT cord-017897-mbwm0ytg 45 24 lungs lung NNS cord-017897-mbwm0ytg 45 25 [ [ -LRB- cord-017897-mbwm0ytg 45 26 32 32 CD cord-017897-mbwm0ytg 45 27 ] ] -RRB- cord-017897-mbwm0ytg 45 28 mainly mainly RB cord-017897-mbwm0ytg 45 29 through through IN cord-017897-mbwm0ytg 45 30 the the DT cord-017897-mbwm0ytg 45 31 cycling cycling NN cord-017897-mbwm0ytg 45 32 collapse collapse NN cord-017897-mbwm0ytg 45 33 - - HYPH cord-017897-mbwm0ytg 45 34 reopening reopen VBG cord-017897-mbwm0ytg 45 35 and and CC cord-017897-mbwm0ytg 45 36 alveolar alveolar NN cord-017897-mbwm0ytg 45 37 overdistention overdistention NN cord-017897-mbwm0ytg 45 38 phenomena phenomenon NNS cord-017897-mbwm0ytg 45 39 that that WDT cord-017897-mbwm0ytg 45 40 contribute contribute VBP cord-017897-mbwm0ytg 45 41 to to IN cord-017897-mbwm0ytg 45 42 the the DT cord-017897-mbwm0ytg 45 43 so so RB cord-017897-mbwm0ytg 45 44 - - HYPH cord-017897-mbwm0ytg 45 45 called call VBN cord-017897-mbwm0ytg 45 46 atelect atelect NN cord-017897-mbwm0ytg 45 47 - - HYPH cord-017897-mbwm0ytg 45 48 trauma trauma NN cord-017897-mbwm0ytg 45 49 [ [ -LRB- cord-017897-mbwm0ytg 45 50 33 33 CD cord-017897-mbwm0ytg 45 51 ] ] -RRB- cord-017897-mbwm0ytg 45 52 . . . cord-017897-mbwm0ytg 46 1 The the DT cord-017897-mbwm0ytg 46 2 application application NN cord-017897-mbwm0ytg 46 3 of of IN cord-017897-mbwm0ytg 46 4 high high JJ cord-017897-mbwm0ytg 46 5 PEEP peep NN cord-017897-mbwm0ytg 46 6 allows allow VBZ cord-017897-mbwm0ytg 46 7 collapsed collapse VBN cord-017897-mbwm0ytg 46 8 alveoli alveolus NNS cord-017897-mbwm0ytg 46 9 reopening reopen VBG cord-017897-mbwm0ytg 46 10 and and CC cord-017897-mbwm0ytg 46 11 intrapulmonary intrapulmonary JJ cord-017897-mbwm0ytg 46 12 shunt shunt NN cord-017897-mbwm0ytg 46 13 reduction reduction NN cord-017897-mbwm0ytg 46 14 , , , cord-017897-mbwm0ytg 46 15 moreover moreover RB cord-017897-mbwm0ytg 46 16 it -PRON- PRP cord-017897-mbwm0ytg 46 17 reduces reduce VBZ cord-017897-mbwm0ytg 46 18 the the DT cord-017897-mbwm0ytg 46 19 repetitive repetitive JJ cord-017897-mbwm0ytg 46 20 alveolar alveolar NN cord-017897-mbwm0ytg 46 21 opening opening NN cord-017897-mbwm0ytg 46 22 and and CC cord-017897-mbwm0ytg 46 23 closing closing NN cord-017897-mbwm0ytg 46 24 which which WDT cord-017897-mbwm0ytg 46 25 occurs occur VBZ cord-017897-mbwm0ytg 46 26 during during IN cord-017897-mbwm0ytg 46 27 the the DT cord-017897-mbwm0ytg 46 28 respiratory respiratory JJ cord-017897-mbwm0ytg 46 29 cycle cycle NN cord-017897-mbwm0ytg 46 30 [ [ -LRB- cord-017897-mbwm0ytg 46 31 34 34 CD cord-017897-mbwm0ytg 46 32 ] ] -RRB- cord-017897-mbwm0ytg 46 33 . . . cord-017897-mbwm0ytg 47 1 However however RB cord-017897-mbwm0ytg 47 2 , , , cord-017897-mbwm0ytg 47 3 it -PRON- PRP cord-017897-mbwm0ytg 47 4 's be VBZ cord-017897-mbwm0ytg 47 5 not not RB cord-017897-mbwm0ytg 47 6 always always RB cord-017897-mbwm0ytg 47 7 useful useful JJ cord-017897-mbwm0ytg 47 8 to to TO cord-017897-mbwm0ytg 47 9 set set VB cord-017897-mbwm0ytg 47 10 high high JJ cord-017897-mbwm0ytg 47 11 PEEP peep NN cord-017897-mbwm0ytg 47 12 levels level NNS cord-017897-mbwm0ytg 47 13 , , , cord-017897-mbwm0ytg 47 14 as as IN cord-017897-mbwm0ytg 47 15 it -PRON- PRP cord-017897-mbwm0ytg 47 16 could could MD cord-017897-mbwm0ytg 47 17 appear appear VB cord-017897-mbwm0ytg 47 18 at at IN cord-017897-mbwm0ytg 47 19 first first RB cord-017897-mbwm0ytg 47 20 ; ; : cord-017897-mbwm0ytg 47 21 indeed indeed RB cord-017897-mbwm0ytg 47 22 , , , cord-017897-mbwm0ytg 47 23 two two CD cord-017897-mbwm0ytg 47 24 randomized randomized JJ cord-017897-mbwm0ytg 47 25 and and CC cord-017897-mbwm0ytg 47 26 controlled control VBN cord-017897-mbwm0ytg 47 27 trials trial NNS cord-017897-mbwm0ytg 47 28 comparing compare VBG cord-017897-mbwm0ytg 47 29 ARDS ARDS NNP cord-017897-mbwm0ytg 47 30 patients patient NNS cord-017897-mbwm0ytg 47 31 treated treat VBN cord-017897-mbwm0ytg 47 32 with with IN cord-017897-mbwm0ytg 47 33 low low JJ cord-017897-mbwm0ytg 47 34 vs. vs. IN cord-017897-mbwm0ytg 47 35 high high JJ cord-017897-mbwm0ytg 47 36 PEEP peep NN cord-017897-mbwm0ytg 47 37 [ [ -LRB- cord-017897-mbwm0ytg 47 38 35 35 CD cord-017897-mbwm0ytg 47 39 , , , cord-017897-mbwm0ytg 47 40 36 36 CD cord-017897-mbwm0ytg 47 41 ] ] -RRB- cord-017897-mbwm0ytg 47 42 have have VBP cord-017897-mbwm0ytg 47 43 not not RB cord-017897-mbwm0ytg 47 44 shown show VBN cord-017897-mbwm0ytg 47 45 any any DT cord-017897-mbwm0ytg 47 46 benefit benefit NN cord-017897-mbwm0ytg 47 47 from from IN cord-017897-mbwm0ytg 47 48 the the DT cord-017897-mbwm0ytg 47 49 use use NN cord-017897-mbwm0ytg 47 50 of of IN cord-017897-mbwm0ytg 47 51 the the DT cord-017897-mbwm0ytg 47 52 high high JJ cord-017897-mbwm0ytg 47 53 PEEP peep NN cord-017897-mbwm0ytg 47 54 strategy strategy NN cord-017897-mbwm0ytg 47 55 . . . cord-017897-mbwm0ytg 48 1 These these DT cord-017897-mbwm0ytg 48 2 contradictory contradictory JJ cord-017897-mbwm0ytg 48 3 results result NNS cord-017897-mbwm0ytg 48 4 can can MD cord-017897-mbwm0ytg 48 5 be be VB cord-017897-mbwm0ytg 48 6 explained explain VBN cord-017897-mbwm0ytg 48 7 by by IN cord-017897-mbwm0ytg 48 8 the the DT cord-017897-mbwm0ytg 48 9 pulmonary pulmonary JJ cord-017897-mbwm0ytg 48 10 recruitment recruitment NN cord-017897-mbwm0ytg 48 11 concept concept NN cord-017897-mbwm0ytg 48 12 , , , cord-017897-mbwm0ytg 48 13 i.e. i.e. FW cord-017897-mbwm0ytg 48 14 , , , cord-017897-mbwm0ytg 48 15 the the DT cord-017897-mbwm0ytg 48 16 volume volume NN cord-017897-mbwm0ytg 48 17 of of IN cord-017897-mbwm0ytg 48 18 collapsed collapse VBN cord-017897-mbwm0ytg 48 19 pulmonary pulmonary JJ cord-017897-mbwm0ytg 48 20 parenchyma parenchyma NN cord-017897-mbwm0ytg 48 21 in in IN cord-017897-mbwm0ytg 48 22 which which WDT cord-017897-mbwm0ytg 48 23 is be VBZ cord-017897-mbwm0ytg 48 24 possible possible JJ cord-017897-mbwm0ytg 48 25 to to TO cord-017897-mbwm0ytg 48 26 re re VB cord-017897-mbwm0ytg 48 27 - - VB cord-017897-mbwm0ytg 48 28 establish establish VB cord-017897-mbwm0ytg 48 29 a a DT cord-017897-mbwm0ytg 48 30 normal normal JJ cord-017897-mbwm0ytg 48 31 aeration aeration NN cord-017897-mbwm0ytg 48 32 by by IN cord-017897-mbwm0ytg 48 33 an an DT cord-017897-mbwm0ytg 48 34 increase increase NN cord-017897-mbwm0ytg 48 35 in in IN cord-017897-mbwm0ytg 48 36 the the DT cord-017897-mbwm0ytg 48 37 airway airway NN cord-017897-mbwm0ytg 48 38 pressure pressure NN cord-017897-mbwm0ytg 48 39 [ [ -LRB- cord-017897-mbwm0ytg 48 40 37 37 CD cord-017897-mbwm0ytg 48 41 ] ] -RRB- cord-017897-mbwm0ytg 48 42 . . . cord-017897-mbwm0ytg 49 1 To to TO cord-017897-mbwm0ytg 49 2 recruit recruit VB cord-017897-mbwm0ytg 49 3 collapsed collapsed JJ cord-017897-mbwm0ytg 49 4 lung lung NN cord-017897-mbwm0ytg 49 5 regions region NNS cord-017897-mbwm0ytg 49 6 and and CC cord-017897-mbwm0ytg 49 7 keep keep VB cord-017897-mbwm0ytg 49 8 them -PRON- PRP cord-017897-mbwm0ytg 49 9 open open JJ cord-017897-mbwm0ytg 49 10 , , , cord-017897-mbwm0ytg 49 11 it -PRON- PRP cord-017897-mbwm0ytg 49 12 is be VBZ cord-017897-mbwm0ytg 49 13 necessary necessary JJ cord-017897-mbwm0ytg 49 14 to to TO cord-017897-mbwm0ytg 49 15 apply apply VB cord-017897-mbwm0ytg 49 16 an an DT cord-017897-mbwm0ytg 49 17 airway airway NN cord-017897-mbwm0ytg 49 18 pressure pressure NN cord-017897-mbwm0ytg 49 19 higher higher RBR cord-017897-mbwm0ytg 49 20 enough enough RB cord-017897-mbwm0ytg 49 21 to to TO cord-017897-mbwm0ytg 49 22 counterbalance counterbalance VB cord-017897-mbwm0ytg 49 23 the the DT cord-017897-mbwm0ytg 49 24 superimposed superimpose VBN cord-017897-mbwm0ytg 49 25 pressure pressure NN cord-017897-mbwm0ytg 49 26 , , , cord-017897-mbwm0ytg 49 27 i.e. i.e. FW cord-017897-mbwm0ytg 49 28 , , , cord-017897-mbwm0ytg 49 29 the the DT cord-017897-mbwm0ytg 49 30 pressure pressure NN cord-017897-mbwm0ytg 49 31 generated generate VBN cord-017897-mbwm0ytg 49 32 by by IN cord-017897-mbwm0ytg 49 33 the the DT cord-017897-mbwm0ytg 49 34 weight weight NN cord-017897-mbwm0ytg 49 35 of of IN cord-017897-mbwm0ytg 49 36 the the DT cord-017897-mbwm0ytg 49 37 lung lung NN cord-017897-mbwm0ytg 49 38 and and CC cord-017897-mbwm0ytg 49 39 the the DT cord-017897-mbwm0ytg 49 40 rib rib NN cord-017897-mbwm0ytg 49 41 cage cage NN cord-017897-mbwm0ytg 49 42 that that WDT cord-017897-mbwm0ytg 49 43 acts act VBZ cord-017897-mbwm0ytg 49 44 on on IN cord-017897-mbwm0ytg 49 45 the the DT cord-017897-mbwm0ytg 49 46 lung lung NN cord-017897-mbwm0ytg 49 47 below below IN cord-017897-mbwm0ytg 49 48 [ [ -LRB- cord-017897-mbwm0ytg 49 49 38 38 CD cord-017897-mbwm0ytg 49 50 ] ] -RRB- cord-017897-mbwm0ytg 49 51 . . . cord-017897-mbwm0ytg 50 1 Several several JJ cord-017897-mbwm0ytg 50 2 maneuvers maneuver NNS cord-017897-mbwm0ytg 50 3 can can MD cord-017897-mbwm0ytg 50 4 be be VB cord-017897-mbwm0ytg 50 5 used use VBN cord-017897-mbwm0ytg 50 6 to to TO cord-017897-mbwm0ytg 50 7 recruit recruit VB cord-017897-mbwm0ytg 50 8 the the DT cord-017897-mbwm0ytg 50 9 lung lung NN cord-017897-mbwm0ytg 50 10 : : : cord-017897-mbwm0ytg 50 11 the the DT cord-017897-mbwm0ytg 50 12 sigh sigh NN cord-017897-mbwm0ytg 50 13 ( ( -LRB- cord-017897-mbwm0ytg 50 14 i.e. i.e. FW cord-017897-mbwm0ytg 50 15 , , , cord-017897-mbwm0ytg 50 16 one one CD cord-017897-mbwm0ytg 50 17 high high JJ cord-017897-mbwm0ytg 50 18 - - HYPH cord-017897-mbwm0ytg 50 19 volume volume NN cord-017897-mbwm0ytg 50 20 breath breath NN cord-017897-mbwm0ytg 50 21 intermittently intermittently RB cord-017897-mbwm0ytg 50 22 provided provide VBN cord-017897-mbwm0ytg 50 23 by by IN cord-017897-mbwm0ytg 50 24 the the DT cord-017897-mbwm0ytg 50 25 ventilator ventilator NN cord-017897-mbwm0ytg 50 26 ) ) -RRB- cord-017897-mbwm0ytg 50 27 , , , cord-017897-mbwm0ytg 50 28 the the DT cord-017897-mbwm0ytg 50 29 extended extended JJ cord-017897-mbwm0ytg 50 30 sigh sigh NN cord-017897-mbwm0ytg 50 31 ( ( -LRB- cord-017897-mbwm0ytg 50 32 i.e. i.e. FW cord-017897-mbwm0ytg 50 33 , , , cord-017897-mbwm0ytg 50 34 a a DT cord-017897-mbwm0ytg 50 35 progressive progressive JJ cord-017897-mbwm0ytg 50 36 increase increase NN cord-017897-mbwm0ytg 50 37 in in IN cord-017897-mbwm0ytg 50 38 PEEP peep NN cord-017897-mbwm0ytg 50 39 or or CC cord-017897-mbwm0ytg 50 40 a a DT cord-017897-mbwm0ytg 50 41 progressive progressive JJ cord-017897-mbwm0ytg 50 42 increase increase NN cord-017897-mbwm0ytg 50 43 in in IN cord-017897-mbwm0ytg 50 44 both both CC cord-017897-mbwm0ytg 50 45 PEEP peep NN cord-017897-mbwm0ytg 50 46 and and CC cord-017897-mbwm0ytg 50 47 plateau plateau NN cord-017897-mbwm0ytg 50 48 pressure pressure NN cord-017897-mbwm0ytg 50 49 ) ) -RRB- cord-017897-mbwm0ytg 50 50 , , , cord-017897-mbwm0ytg 50 51 and and CC cord-017897-mbwm0ytg 50 52 the the DT cord-017897-mbwm0ytg 50 53 sustained sustained JJ cord-017897-mbwm0ytg 50 54 inflation inflation NN cord-017897-mbwm0ytg 50 55 ( ( -LRB- cord-017897-mbwm0ytg 50 56 i.e. i.e. FW cord-017897-mbwm0ytg 50 57 , , , cord-017897-mbwm0ytg 50 58 a a DT cord-017897-mbwm0ytg 50 59 static static JJ cord-017897-mbwm0ytg 50 60 sustained sustained JJ cord-017897-mbwm0ytg 50 61 increase increase NN cord-017897-mbwm0ytg 50 62 in in IN cord-017897-mbwm0ytg 50 63 the the DT cord-017897-mbwm0ytg 50 64 airway airway NN cord-017897-mbwm0ytg 50 65 pressure pressure NN cord-017897-mbwm0ytg 50 66 [ [ -LRB- cord-017897-mbwm0ytg 50 67 35 35 CD cord-017897-mbwm0ytg 50 68 ] ] -RRB- cord-017897-mbwm0ytg 50 69 [ [ -LRB- cord-017897-mbwm0ytg 50 70 36 36 CD cord-017897-mbwm0ytg 50 71 ] ] -RRB- cord-017897-mbwm0ytg 51 1 [ [ -LRB- cord-017897-mbwm0ytg 51 2 37 37 CD cord-017897-mbwm0ytg 51 3 ] ] -RRB- cord-017897-mbwm0ytg 51 4 [ [ -LRB- cord-017897-mbwm0ytg 51 5 38 38 CD cord-017897-mbwm0ytg 51 6 ] ] -RRB- cord-017897-mbwm0ytg 52 1 [ [ -LRB- cord-017897-mbwm0ytg 52 2 39 39 CD cord-017897-mbwm0ytg 52 3 ] ] -RRB- cord-017897-mbwm0ytg 53 1 [ [ -LRB- cord-017897-mbwm0ytg 53 2 40 40 CD cord-017897-mbwm0ytg 53 3 ] ] -RRB- cord-017897-mbwm0ytg 53 4 protracted protract VBN cord-017897-mbwm0ytg 53 5 for for IN cord-017897-mbwm0ytg 53 6 20 20 CD cord-017897-mbwm0ytg 53 7 - - SYM cord-017897-mbwm0ytg 53 8 40 40 CD cord-017897-mbwm0ytg 53 9 seconds second NNS cord-017897-mbwm0ytg 53 10 ) ) -RRB- cord-017897-mbwm0ytg 54 1 [ [ -LRB- cord-017897-mbwm0ytg 54 2 39 39 CD cord-017897-mbwm0ytg 54 3 ] ] -RRB- cord-017897-mbwm0ytg 54 4 . . . cord-017897-mbwm0ytg 55 1 The the DT cord-017897-mbwm0ytg 55 2 target target NN cord-017897-mbwm0ytg 55 3 of of IN cord-017897-mbwm0ytg 55 4 these these DT cord-017897-mbwm0ytg 55 5 maneuvers maneuver NNS cord-017897-mbwm0ytg 55 6 is be VBZ cord-017897-mbwm0ytg 55 7 to to TO cord-017897-mbwm0ytg 55 8 increase increase VB cord-017897-mbwm0ytg 55 9 the the DT cord-017897-mbwm0ytg 55 10 transpulmonary transpulmonary JJ cord-017897-mbwm0ytg 55 11 pressure pressure NN cord-017897-mbwm0ytg 55 12 for for IN cord-017897-mbwm0ytg 55 13 a a DT cord-017897-mbwm0ytg 55 14 period period NN cord-017897-mbwm0ytg 55 15 of of IN cord-017897-mbwm0ytg 55 16 time time NN cord-017897-mbwm0ytg 55 17 sufficiently sufficiently RB cord-017897-mbwm0ytg 55 18 long long JJ cord-017897-mbwm0ytg 55 19 to to TO cord-017897-mbwm0ytg 55 20 reinflate reinflate VB cord-017897-mbwm0ytg 55 21 the the DT cord-017897-mbwm0ytg 55 22 alveolar alveolar JJ cord-017897-mbwm0ytg 55 23 units unit NNS cord-017897-mbwm0ytg 55 24 previously previously RB cord-017897-mbwm0ytg 55 25 closed close VBD cord-017897-mbwm0ytg 55 26 . . . cord-017897-mbwm0ytg 56 1 While while IN cord-017897-mbwm0ytg 56 2 these these DT cord-017897-mbwm0ytg 56 3 maneuvers maneuver NNS cord-017897-mbwm0ytg 56 4 are be VBP cord-017897-mbwm0ytg 56 5 able able JJ cord-017897-mbwm0ytg 56 6 to to TO cord-017897-mbwm0ytg 56 7 improve improve VB cord-017897-mbwm0ytg 56 8 the the DT cord-017897-mbwm0ytg 56 9 oxygenation oxygenation NN cord-017897-mbwm0ytg 56 10 for for IN cord-017897-mbwm0ytg 56 11 a a DT cord-017897-mbwm0ytg 56 12 variable variable JJ cord-017897-mbwm0ytg 56 13 period period NN cord-017897-mbwm0ytg 56 14 of of IN cord-017897-mbwm0ytg 56 15 time time NN cord-017897-mbwm0ytg 56 16 , , , cord-017897-mbwm0ytg 56 17 their -PRON- PRP$ cord-017897-mbwm0ytg 56 18 systematic systematic JJ cord-017897-mbwm0ytg 56 19 use use NN cord-017897-mbwm0ytg 56 20 did do VBD cord-017897-mbwm0ytg 56 21 not not RB cord-017897-mbwm0ytg 56 22 result result VB cord-017897-mbwm0ytg 56 23 in in IN cord-017897-mbwm0ytg 56 24 a a DT cord-017897-mbwm0ytg 56 25 mortality mortality NN cord-017897-mbwm0ytg 56 26 reduction reduction NN cord-017897-mbwm0ytg 56 27 [ [ -LRB- cord-017897-mbwm0ytg 56 28 40 40 CD cord-017897-mbwm0ytg 56 29 ] ] -RRB- cord-017897-mbwm0ytg 56 30 . . . cord-017897-mbwm0ytg 57 1 While while IN cord-017897-mbwm0ytg 57 2 the the DT cord-017897-mbwm0ytg 57 3 lung lung NN cord-017897-mbwm0ytg 57 4 CT CT NNP cord-017897-mbwm0ytg 57 5 scan scan NN cord-017897-mbwm0ytg 57 6 is be VBZ cord-017897-mbwm0ytg 57 7 the the DT cord-017897-mbwm0ytg 57 8 gold gold NN cord-017897-mbwm0ytg 57 9 standard standard NN cord-017897-mbwm0ytg 57 10 for for IN cord-017897-mbwm0ytg 57 11 the the DT cord-017897-mbwm0ytg 57 12 potential potential NN cord-017897-mbwm0ytg 57 13 of of IN cord-017897-mbwm0ytg 57 14 recruitment recruitment NN cord-017897-mbwm0ytg 57 15 evaluation evaluation NN cord-017897-mbwm0ytg 57 16 , , , cord-017897-mbwm0ytg 57 17 the the DT cord-017897-mbwm0ytg 57 18 lung lung NN cord-017897-mbwm0ytg 57 19 ultrasound ultrasound NN cord-017897-mbwm0ytg 57 20 seems seem VBZ cord-017897-mbwm0ytg 57 21 to to TO cord-017897-mbwm0ytg 57 22 be be VB cord-017897-mbwm0ytg 57 23 a a DT cord-017897-mbwm0ytg 57 24 promising promising JJ cord-017897-mbwm0ytg 57 25 alternative alternative NN cord-017897-mbwm0ytg 57 26 available available JJ cord-017897-mbwm0ytg 57 27 at at IN cord-017897-mbwm0ytg 57 28 the the DT cord-017897-mbwm0ytg 57 29 patient patient NN cord-017897-mbwm0ytg 57 30 's 's POS cord-017897-mbwm0ytg 57 31 bedside bedside NN cord-017897-mbwm0ytg 57 32 with with IN cord-017897-mbwm0ytg 57 33 several several JJ cord-017897-mbwm0ytg 57 34 advantages advantage NNS cord-017897-mbwm0ytg 57 35 such such JJ cord-017897-mbwm0ytg 57 36 as as IN cord-017897-mbwm0ytg 57 37 safety safety NN cord-017897-mbwm0ytg 57 38 and and CC cord-017897-mbwm0ytg 57 39 repeatability repeatability NN cord-017897-mbwm0ytg 57 40 ; ; : cord-017897-mbwm0ytg 57 41 however however RB cord-017897-mbwm0ytg 57 42 further further JJ cord-017897-mbwm0ytg 57 43 studies study NNS cord-017897-mbwm0ytg 57 44 are be VBP cord-017897-mbwm0ytg 57 45 necessary necessary JJ cord-017897-mbwm0ytg 57 46 to to TO cord-017897-mbwm0ytg 57 47 confirm confirm VB cord-017897-mbwm0ytg 57 48 this this DT cord-017897-mbwm0ytg 57 49 data datum NNS cord-017897-mbwm0ytg 57 50 [ [ -LRB- cord-017897-mbwm0ytg 57 51 41 41 CD cord-017897-mbwm0ytg 57 52 ] ] -RRB- cord-017897-mbwm0ytg 57 53 . . . cord-017897-mbwm0ytg 58 1 As as IN cord-017897-mbwm0ytg 58 2 known know VBN cord-017897-mbwm0ytg 58 3 , , , cord-017897-mbwm0ytg 58 4 the the DT cord-017897-mbwm0ytg 58 5 choice choice NN cord-017897-mbwm0ytg 58 6 of of IN cord-017897-mbwm0ytg 58 7 a a DT cord-017897-mbwm0ytg 58 8 too too RB cord-017897-mbwm0ytg 58 9 low low JJ cord-017897-mbwm0ytg 58 10 end end NN cord-017897-mbwm0ytg 58 11 - - HYPH cord-017897-mbwm0ytg 58 12 expiratory expiratory JJ cord-017897-mbwm0ytg 58 13 positive positive JJ cord-017897-mbwm0ytg 58 14 pressure pressure NN cord-017897-mbwm0ytg 58 15 could could MD cord-017897-mbwm0ytg 58 16 cause cause VB cord-017897-mbwm0ytg 58 17 the the DT cord-017897-mbwm0ytg 58 18 collapse collapse NN cord-017897-mbwm0ytg 58 19 of of IN cord-017897-mbwm0ytg 58 20 otherwise otherwise RB cord-017897-mbwm0ytg 58 21 recruited recruit VBN cord-017897-mbwm0ytg 58 22 parenchymal parenchymal JJ cord-017897-mbwm0ytg 58 23 areas area NNS cord-017897-mbwm0ytg 58 24 , , , cord-017897-mbwm0ytg 58 25 while while IN cord-017897-mbwm0ytg 58 26 the the DT cord-017897-mbwm0ytg 58 27 choice choice NN cord-017897-mbwm0ytg 58 28 of of IN cord-017897-mbwm0ytg 58 29 a a DT cord-017897-mbwm0ytg 58 30 too too RB cord-017897-mbwm0ytg 58 31 high high JJ cord-017897-mbwm0ytg 58 32 end end NN cord-017897-mbwm0ytg 58 33 - - HYPH cord-017897-mbwm0ytg 58 34 expiratory expiratory JJ cord-017897-mbwm0ytg 58 35 positive positive JJ cord-017897-mbwm0ytg 58 36 pressure pressure NN cord-017897-mbwm0ytg 58 37 could could MD cord-017897-mbwm0ytg 58 38 increase increase VB cord-017897-mbwm0ytg 58 39 dead dead JJ cord-017897-mbwm0ytg 58 40 space space NN cord-017897-mbwm0ytg 58 41 and and CC cord-017897-mbwm0ytg 58 42 tissue tissue NN cord-017897-mbwm0ytg 58 43 stretch stretch NN cord-017897-mbwm0ytg 58 44 thus thus RB cord-017897-mbwm0ytg 58 45 raising raise VBG cord-017897-mbwm0ytg 58 46 the the DT cord-017897-mbwm0ytg 58 47 risk risk NN cord-017897-mbwm0ytg 58 48 of of IN cord-017897-mbwm0ytg 58 49 lung lung NN cord-017897-mbwm0ytg 58 50 damage damage NN cord-017897-mbwm0ytg 58 51 . . . cord-017897-mbwm0ytg 59 1 The the DT cord-017897-mbwm0ytg 59 2 PEEP peep NN cord-017897-mbwm0ytg 59 3 optimization optimization NN cord-017897-mbwm0ytg 59 4 is be VBZ cord-017897-mbwm0ytg 59 5 therefore therefore RB cord-017897-mbwm0ytg 59 6 crucial crucial JJ cord-017897-mbwm0ytg 59 7 in in IN cord-017897-mbwm0ytg 59 8 the the DT cord-017897-mbwm0ytg 59 9 individual individual JJ cord-017897-mbwm0ytg 59 10 patient patient NN cord-017897-mbwm0ytg 59 11 to to TO cord-017897-mbwm0ytg 59 12 avoid avoid VB cord-017897-mbwm0ytg 59 13 the the DT cord-017897-mbwm0ytg 59 14 continuous continuous JJ cord-017897-mbwm0ytg 59 15 opening opening NN cord-017897-mbwm0ytg 59 16 and and CC cord-017897-mbwm0ytg 59 17 closing closing NN cord-017897-mbwm0ytg 59 18 and and CC cord-017897-mbwm0ytg 59 19 the the DT cord-017897-mbwm0ytg 59 20 overdistention overdistention NN cord-017897-mbwm0ytg 59 21 phenomena phenomenon NNS cord-017897-mbwm0ytg 59 22 in in IN cord-017897-mbwm0ytg 59 23 some some DT cord-017897-mbwm0ytg 59 24 parenchymal parenchymal JJ cord-017897-mbwm0ytg 59 25 areas area NNS cord-017897-mbwm0ytg 59 26 . . . cord-017897-mbwm0ytg 60 1 Different different JJ cord-017897-mbwm0ytg 60 2 approaches approach NNS cord-017897-mbwm0ytg 60 3 have have VBP cord-017897-mbwm0ytg 60 4 been be VBN cord-017897-mbwm0ytg 60 5 proposed propose VBN cord-017897-mbwm0ytg 60 6 to to TO cord-017897-mbwm0ytg 60 7 choose choose VB cord-017897-mbwm0ytg 60 8 the the DT cord-017897-mbwm0ytg 60 9 best good JJS cord-017897-mbwm0ytg 60 10 PEEP peep NN cord-017897-mbwm0ytg 60 11 , , , cord-017897-mbwm0ytg 60 12 but but CC cord-017897-mbwm0ytg 60 13 the the DT cord-017897-mbwm0ytg 60 14 most most RBS cord-017897-mbwm0ytg 60 15 commonly commonly RB cord-017897-mbwm0ytg 60 16 used use VBN cord-017897-mbwm0ytg 60 17 is be VBZ cord-017897-mbwm0ytg 60 18 the the DT cord-017897-mbwm0ytg 60 19 one one NN cord-017897-mbwm0ytg 60 20 based base VBN cord-017897-mbwm0ytg 60 21 on on IN cord-017897-mbwm0ytg 60 22 the the DT cord-017897-mbwm0ytg 60 23 PEEP peep NN cord-017897-mbwm0ytg 60 24 / / SYM cord-017897-mbwm0ytg 60 25 FiO fio NN cord-017897-mbwm0ytg 60 26 2 2 CD cord-017897-mbwm0ytg 60 27 table table NN cord-017897-mbwm0ytg 60 28 , , , cord-017897-mbwm0ytg 60 29 which which WDT cord-017897-mbwm0ytg 60 30 use use VBP cord-017897-mbwm0ytg 60 31 the the DT cord-017897-mbwm0ytg 60 32 patient patient NN cord-017897-mbwm0ytg 60 33 's 's POS cord-017897-mbwm0ytg 60 34 saturation saturation NN cord-017897-mbwm0ytg 60 35 / / SYM cord-017897-mbwm0ytg 60 36 oxygenation oxygenation NN cord-017897-mbwm0ytg 60 37 as as IN cord-017897-mbwm0ytg 60 38 target target NN cord-017897-mbwm0ytg 60 39 [ [ -LRB- cord-017897-mbwm0ytg 60 40 36 36 CD cord-017897-mbwm0ytg 60 41 ] ] -RRB- cord-017897-mbwm0ytg 60 42 . . . cord-017897-mbwm0ytg 61 1 Another another DT cord-017897-mbwm0ytg 61 2 method method NN cord-017897-mbwm0ytg 61 3 is be VBZ cord-017897-mbwm0ytg 61 4 based base VBN cord-017897-mbwm0ytg 61 5 on on IN cord-017897-mbwm0ytg 61 6 the the DT cord-017897-mbwm0ytg 61 7 respiratory respiratory JJ cord-017897-mbwm0ytg 61 8 mechanics mechanic NNS cord-017897-mbwm0ytg 61 9 : : : cord-017897-mbwm0ytg 61 10 PEEP PEEP NNP cord-017897-mbwm0ytg 61 11 is be VBZ cord-017897-mbwm0ytg 61 12 progressively progressively RB cord-017897-mbwm0ytg 61 13 increased increase VBN cord-017897-mbwm0ytg 61 14 while while IN cord-017897-mbwm0ytg 61 15 keeping keep VBG cord-017897-mbwm0ytg 61 16 the the DT cord-017897-mbwm0ytg 61 17 tidal tidal JJ cord-017897-mbwm0ytg 61 18 volume volume NN cord-017897-mbwm0ytg 61 19 constant constant NN cord-017897-mbwm0ytg 61 20 and and CC cord-017897-mbwm0ytg 61 21 the the DT cord-017897-mbwm0ytg 61 22 airway airway NN cord-017897-mbwm0ytg 61 23 pressure pressure NN cord-017897-mbwm0ytg 61 24 within within IN cord-017897-mbwm0ytg 61 25 a a DT cord-017897-mbwm0ytg 61 26 safety safety NN cord-017897-mbwm0ytg 61 27 range range NN cord-017897-mbwm0ytg 61 28 ( ( -LRB- cord-017897-mbwm0ytg 61 29 26 26 CD cord-017897-mbwm0ytg 61 30 - - SYM cord-017897-mbwm0ytg 61 31 28 28 CD cord-017897-mbwm0ytg 61 32 cmH cmh NN cord-017897-mbwm0ytg 61 33 2 2 CD cord-017897-mbwm0ytg 61 34 O o NN cord-017897-mbwm0ytg 61 35 ) ) -RRB- cord-017897-mbwm0ytg 61 36 [ [ -LRB- cord-017897-mbwm0ytg 61 37 42 42 CD cord-017897-mbwm0ytg 61 38 ] ] -RRB- cord-017897-mbwm0ytg 61 39 . . . cord-017897-mbwm0ytg 62 1 Conversely conversely RB cord-017897-mbwm0ytg 62 2 , , , cord-017897-mbwm0ytg 62 3 our -PRON- PRP$ cord-017897-mbwm0ytg 62 4 group group NN cord-017897-mbwm0ytg 62 5 uses use VBZ cord-017897-mbwm0ytg 62 6 the the DT cord-017897-mbwm0ytg 62 7 esophageal esophageal JJ cord-017897-mbwm0ytg 62 8 pressure pressure NN cord-017897-mbwm0ytg 62 9 variation variation NN cord-017897-mbwm0ytg 62 10 during during IN cord-017897-mbwm0ytg 62 11 the the DT cord-017897-mbwm0ytg 62 12 breath breath NN cord-017897-mbwm0ytg 62 13 , , , cord-017897-mbwm0ytg 62 14 to to TO cord-017897-mbwm0ytg 62 15 evaluate evaluate VB cord-017897-mbwm0ytg 62 16 the the DT cord-017897-mbwm0ytg 62 17 transpulmonary transpulmonary JJ cord-017897-mbwm0ytg 62 18 pressure pressure NN cord-017897-mbwm0ytg 62 19 . . . cord-017897-mbwm0ytg 63 1 It -PRON- PRP cord-017897-mbwm0ytg 63 2 is be VBZ cord-017897-mbwm0ytg 63 3 measured measure VBN cord-017897-mbwm0ytg 63 4 as as IN cord-017897-mbwm0ytg 63 5 : : : cord-017897-mbwm0ytg 63 6 ( ( -LRB- cord-017897-mbwm0ytg 63 7 plateau plateau NNP cord-017897-mbwm0ytg 63 8 pressure pressure NNP cord-017897-mbwm0ytg 63 9 − − NNP cord-017897-mbwm0ytg 63 10 total total JJ cord-017897-mbwm0ytg 63 11 PEEP peep NN cord-017897-mbwm0ytg 63 12 ) ) -RRB- cord-017897-mbwm0ytg 63 13 − − NN cord-017897-mbwm0ytg 64 1 ( ( -LRB- cord-017897-mbwm0ytg 64 2 esophageal esophageal JJ cord-017897-mbwm0ytg 64 3 pressure pressure NN cord-017897-mbwm0ytg 64 4 at at IN cord-017897-mbwm0ytg 64 5 plateau plateau NN cord-017897-mbwm0ytg 64 6 − − CD cord-017897-mbwm0ytg 64 7 esophageal esophageal JJ cord-017897-mbwm0ytg 64 8 pressure pressure NN cord-017897-mbwm0ytg 64 9 at at IN cord-017897-mbwm0ytg 64 10 ZEEP ZEEP NNP cord-017897-mbwm0ytg 64 11 _SP cord-017897-mbwm0ytg 65 1 The the DT cord-017897-mbwm0ytg 65 2 main main JJ cord-017897-mbwm0ytg 65 3 determinants determinant NNS cord-017897-mbwm0ytg 65 4 of of IN cord-017897-mbwm0ytg 65 5 the the DT cord-017897-mbwm0ytg 65 6 ventilator ventilator NN cord-017897-mbwm0ytg 65 7 - - HYPH cord-017897-mbwm0ytg 65 8 induced induce VBN cord-017897-mbwm0ytg 65 9 lung lung NN cord-017897-mbwm0ytg 65 10 injury injury NN cord-017897-mbwm0ytg 65 11 are be VBP cord-017897-mbwm0ytg 65 12 strain strain NN cord-017897-mbwm0ytg 65 13 ( ( -LRB- cord-017897-mbwm0ytg 65 14 defined define VBN cord-017897-mbwm0ytg 65 15 as as IN cord-017897-mbwm0ytg 65 16 the the DT cord-017897-mbwm0ytg 65 17 lung lung NN cord-017897-mbwm0ytg 65 18 deformation deformation NN cord-017897-mbwm0ytg 65 19 induced induce VBN cord-017897-mbwm0ytg 65 20 by by IN cord-017897-mbwm0ytg 65 21 the the DT cord-017897-mbwm0ytg 65 22 application application NN cord-017897-mbwm0ytg 65 23 of of IN cord-017897-mbwm0ytg 65 24 the the DT cord-017897-mbwm0ytg 65 25 tidal tidal JJ cord-017897-mbwm0ytg 65 26 volume volume NN cord-017897-mbwm0ytg 65 27 ) ) -RRB- cord-017897-mbwm0ytg 65 28 and and CC cord-017897-mbwm0ytg 65 29 stress stress NN cord-017897-mbwm0ytg 65 30 ( ( -LRB- cord-017897-mbwm0ytg 65 31 i.e. i.e. FW cord-017897-mbwm0ytg 65 32 , , , cord-017897-mbwm0ytg 65 33 the the DT cord-017897-mbwm0ytg 65 34 transpulmonary transpulmonary NNP cord-017897-mbwm0ytg 65 35 pressure pressure NN cord-017897-mbwm0ytg 65 36 determined determine VBN cord-017897-mbwm0ytg 65 37 by by IN cord-017897-mbwm0ytg 65 38 the the DT cord-017897-mbwm0ytg 65 39 strain strain NN cord-017897-mbwm0ytg 65 40 ) ) -RRB- cord-017897-mbwm0ytg 66 1 [ [ -LRB- cord-017897-mbwm0ytg 66 2 44 44 CD cord-017897-mbwm0ytg 66 3 ] ] -RRB- cord-017897-mbwm0ytg 66 4 . . . cord-017897-mbwm0ytg 67 1 Therefore therefore RB cord-017897-mbwm0ytg 67 2 , , , cord-017897-mbwm0ytg 67 3 to to TO cord-017897-mbwm0ytg 67 4 maintain maintain VB cord-017897-mbwm0ytg 67 5 low low JJ cord-017897-mbwm0ytg 67 6 stress stress NN cord-017897-mbwm0ytg 67 7 and and CC cord-017897-mbwm0ytg 67 8 strain strain NN cord-017897-mbwm0ytg 67 9 , , , cord-017897-mbwm0ytg 67 10 it -PRON- PRP cord-017897-mbwm0ytg 67 11 is be VBZ cord-017897-mbwm0ytg 67 12 necessary necessary JJ cord-017897-mbwm0ytg 67 13 to to TO cord-017897-mbwm0ytg 67 14 apply apply VB cord-017897-mbwm0ytg 67 15 a a DT cord-017897-mbwm0ytg 67 16 low low JJ cord-017897-mbwm0ytg 67 17 tidal tidal JJ cord-017897-mbwm0ytg 67 18 volume volume NN cord-017897-mbwm0ytg 67 19 or or CC cord-017897-mbwm0ytg 67 20 have have VBP cord-017897-mbwm0ytg 67 21 a a DT cord-017897-mbwm0ytg 67 22 high high JJ cord-017897-mbwm0ytg 67 23 residual residual JJ cord-017897-mbwm0ytg 67 24 functional functional JJ cord-017897-mbwm0ytg 67 25 capacity capacity NN cord-017897-mbwm0ytg 67 26 [ [ -LRB- cord-017897-mbwm0ytg 67 27 42 42 CD cord-017897-mbwm0ytg 67 28 , , , cord-017897-mbwm0ytg 67 29 45 45 CD cord-017897-mbwm0ytg 67 30 ] ] -RRB- cord-017897-mbwm0ytg 67 31 . . . cord-017897-mbwm0ytg 68 1 A a DT cord-017897-mbwm0ytg 68 2 recent recent JJ cord-017897-mbwm0ytg 68 3 meta meta JJ cord-017897-mbwm0ytg 68 4 - - HYPH cord-017897-mbwm0ytg 68 5 analysis analysis NN cord-017897-mbwm0ytg 68 6 has have VBZ cord-017897-mbwm0ytg 68 7 shown show VBN cord-017897-mbwm0ytg 68 8 how how WRB cord-017897-mbwm0ytg 68 9 the the DT cord-017897-mbwm0ytg 68 10 use use NN cord-017897-mbwm0ytg 68 11 of of IN cord-017897-mbwm0ytg 68 12 " " `` cord-017897-mbwm0ytg 68 13 protective protective JJ cord-017897-mbwm0ytg 68 14 ventilation ventilation NN cord-017897-mbwm0ytg 68 15 , , , cord-017897-mbwm0ytg 68 16 " " '' cord-017897-mbwm0ytg 68 17 with with IN cord-017897-mbwm0ytg 68 18 a a DT cord-017897-mbwm0ytg 68 19 tidal tidal JJ cord-017897-mbwm0ytg 68 20 volume volume NN cord-017897-mbwm0ytg 68 21 of of IN cord-017897-mbwm0ytg 68 22 6 6 CD cord-017897-mbwm0ytg 68 23 mL ml NN cord-017897-mbwm0ytg 68 24 / / SYM cord-017897-mbwm0ytg 68 25 kg kg NN cord-017897-mbwm0ytg 68 26 ( ( -LRB- cord-017897-mbwm0ytg 68 27 calculated calculate VBN cord-017897-mbwm0ytg 68 28 on on IN cord-017897-mbwm0ytg 68 29 kg kg NNS cord-017897-mbwm0ytg 68 30 of of IN cord-017897-mbwm0ytg 68 31 ideal ideal JJ cord-017897-mbwm0ytg 68 32 body body NN cord-017897-mbwm0ytg 68 33 weight weight NN cord-017897-mbwm0ytg 68 34 ) ) -RRB- cord-017897-mbwm0ytg 68 35 , , , cord-017897-mbwm0ytg 68 36 guarantees guarantee VBZ cord-017897-mbwm0ytg 68 37 a a DT cord-017897-mbwm0ytg 68 38 reduction reduction NN cord-017897-mbwm0ytg 68 39 in in IN cord-017897-mbwm0ytg 68 40 mortality mortality NN cord-017897-mbwm0ytg 68 41 [ [ -LRB- cord-017897-mbwm0ytg 68 42 46 46 CD cord-017897-mbwm0ytg 68 43 ] ] -RRB- cord-017897-mbwm0ytg 68 44 . . . cord-017897-mbwm0ytg 69 1 Since since IN cord-017897-mbwm0ytg 69 2 the the DT cord-017897-mbwm0ytg 69 3 actual actual JJ cord-017897-mbwm0ytg 69 4 body body NN cord-017897-mbwm0ytg 69 5 weight weight NN cord-017897-mbwm0ytg 69 6 is be VBZ cord-017897-mbwm0ytg 69 7 n't not RB cord-017897-mbwm0ytg 69 8 an an DT cord-017897-mbwm0ytg 69 9 accurate accurate JJ cord-017897-mbwm0ytg 69 10 index index NN cord-017897-mbwm0ytg 69 11 of of IN cord-017897-mbwm0ytg 69 12 lung lung NN cord-017897-mbwm0ytg 69 13 size size NN cord-017897-mbwm0ytg 69 14 , , , cord-017897-mbwm0ytg 69 15 it -PRON- PRP cord-017897-mbwm0ytg 69 16 is be VBZ cord-017897-mbwm0ytg 69 17 recommended recommend VBN cord-017897-mbwm0ytg 69 18 the the DT cord-017897-mbwm0ytg 69 19 use use NN cord-017897-mbwm0ytg 69 20 of of IN cord-017897-mbwm0ytg 69 21 the the DT cord-017897-mbwm0ytg 69 22 ideal ideal JJ cord-017897-mbwm0ytg 69 23 weight weight NN cord-017897-mbwm0ytg 69 24 ( ( -LRB- cord-017897-mbwm0ytg 69 25 calculated calculate VBN cord-017897-mbwm0ytg 69 26 based base VBN cord-017897-mbwm0ytg 69 27 on on IN cord-017897-mbwm0ytg 69 28 gender gender NN cord-017897-mbwm0ytg 69 29 and and CC cord-017897-mbwm0ytg 69 30 height height NN cord-017897-mbwm0ytg 69 31 ) ) -RRB- cord-017897-mbwm0ytg 69 32 to to TO cord-017897-mbwm0ytg 69 33 calculate calculate VB cord-017897-mbwm0ytg 69 34 the the DT cord-017897-mbwm0ytg 69 35 best good JJS cord-017897-mbwm0ytg 69 36 tidal tidal JJ cord-017897-mbwm0ytg 69 37 volume volume NN cord-017897-mbwm0ytg 69 38 ; ; : cord-017897-mbwm0ytg 69 39 however however RB cord-017897-mbwm0ytg 69 40 , , , cord-017897-mbwm0ytg 69 41 the the DT cord-017897-mbwm0ytg 69 42 ideal ideal JJ cord-017897-mbwm0ytg 69 43 weight weight NN cord-017897-mbwm0ytg 69 44 is be VBZ cord-017897-mbwm0ytg 69 45 not not RB cord-017897-mbwm0ytg 69 46 correlated correlate VBN cord-017897-mbwm0ytg 69 47 with with IN cord-017897-mbwm0ytg 69 48 the the DT cord-017897-mbwm0ytg 69 49 functional functional JJ cord-017897-mbwm0ytg 69 50 residual residual JJ cord-017897-mbwm0ytg 69 51 capacity capacity NN cord-017897-mbwm0ytg 69 52 of of IN cord-017897-mbwm0ytg 69 53 the the DT cord-017897-mbwm0ytg 69 54 lung lung NN cord-017897-mbwm0ytg 69 55 , , , cord-017897-mbwm0ytg 69 56 highlighting highlight VBG cord-017897-mbwm0ytg 69 57 that that IN cord-017897-mbwm0ytg 69 58 the the DT cord-017897-mbwm0ytg 69 59 same same JJ cord-017897-mbwm0ytg 69 60 tidal tidal JJ cord-017897-mbwm0ytg 69 61 volume volume NN cord-017897-mbwm0ytg 69 62 can can MD cord-017897-mbwm0ytg 69 63 generate generate VB cord-017897-mbwm0ytg 69 64 very very RB cord-017897-mbwm0ytg 69 65 different different JJ cord-017897-mbwm0ytg 69 66 stress stress NN cord-017897-mbwm0ytg 69 67 and and CC cord-017897-mbwm0ytg 69 68 strain strain NN cord-017897-mbwm0ytg 69 69 values value NNS cord-017897-mbwm0ytg 69 70 [ [ -LRB- cord-017897-mbwm0ytg 69 71 47 47 CD cord-017897-mbwm0ytg 69 72 ] ] -RRB- cord-017897-mbwm0ytg 69 73 in in IN cord-017897-mbwm0ytg 69 74 people people NNS cord-017897-mbwm0ytg 69 75 with with IN cord-017897-mbwm0ytg 69 76 the the DT cord-017897-mbwm0ytg 69 77 same same JJ cord-017897-mbwm0ytg 69 78 gender gender NN cord-017897-mbwm0ytg 69 79 and and CC cord-017897-mbwm0ytg 69 80 height height NN cord-017897-mbwm0ytg 69 81 but but CC cord-017897-mbwm0ytg 69 82 different different JJ cord-017897-mbwm0ytg 69 83 functional functional JJ cord-017897-mbwm0ytg 69 84 residual residual JJ cord-017897-mbwm0ytg 69 85 capacity capacity NN cord-017897-mbwm0ytg 69 86 . . . cord-017897-mbwm0ytg 70 1 Amato Amato NNP cord-017897-mbwm0ytg 70 2 , , , cord-017897-mbwm0ytg 70 3 in in IN cord-017897-mbwm0ytg 70 4 a a DT cord-017897-mbwm0ytg 70 5 recent recent JJ cord-017897-mbwm0ytg 70 6 study study NN cord-017897-mbwm0ytg 70 7 performed perform VBN cord-017897-mbwm0ytg 70 8 over over IN cord-017897-mbwm0ytg 70 9 a a DT cord-017897-mbwm0ytg 70 10 group group NN cord-017897-mbwm0ytg 70 11 of of IN cord-017897-mbwm0ytg 70 12 3500 3500 CD cord-017897-mbwm0ytg 70 13 patients patient NNS cord-017897-mbwm0ytg 70 14 with with IN cord-017897-mbwm0ytg 70 15 ARDS ARDS NNP cord-017897-mbwm0ytg 70 16 ventilated ventilate VBN cord-017897-mbwm0ytg 70 17 with with IN cord-017897-mbwm0ytg 70 18 different different JJ cord-017897-mbwm0ytg 70 19 combinations combination NNS cord-017897-mbwm0ytg 70 20 of of IN cord-017897-mbwm0ytg 70 21 PEEP peep NN cord-017897-mbwm0ytg 70 22 and and CC cord-017897-mbwm0ytg 70 23 tidal tidal JJ cord-017897-mbwm0ytg 70 24 volume volume NN cord-017897-mbwm0ytg 70 25 , , , cord-017897-mbwm0ytg 70 26 showed show VBD cord-017897-mbwm0ytg 70 27 that that IN cord-017897-mbwm0ytg 70 28 the the DT cord-017897-mbwm0ytg 70 29 variable variable NN cord-017897-mbwm0ytg 70 30 most most RBS cord-017897-mbwm0ytg 70 31 closely closely RB cord-017897-mbwm0ytg 70 32 associated associate VBN cord-017897-mbwm0ytg 70 33 with with IN cord-017897-mbwm0ytg 70 34 the the DT cord-017897-mbwm0ytg 70 35 outcome outcome NN cord-017897-mbwm0ytg 70 36 of of IN cord-017897-mbwm0ytg 70 37 patients patient NNS cord-017897-mbwm0ytg 70 38 is be VBZ cord-017897-mbwm0ytg 70 39 represented represent VBN cord-017897-mbwm0ytg 70 40 by by IN cord-017897-mbwm0ytg 70 41 the the DT cord-017897-mbwm0ytg 70 42 driving drive VBG cord-017897-mbwm0ytg 70 43 pressure pressure NN cord-017897-mbwm0ytg 70 44 of of IN cord-017897-mbwm0ytg 70 45 the the DT cord-017897-mbwm0ytg 70 46 airways airway NNS cord-017897-mbwm0ytg 70 47 , , , cord-017897-mbwm0ytg 70 48 calculated calculate VBN cord-017897-mbwm0ytg 70 49 as as IN cord-017897-mbwm0ytg 70 50 ( ( -LRB- cord-017897-mbwm0ytg 70 51 plateau plateau NNP cord-017897-mbwm0ytg 70 52 pressure pressure NNP cord-017897-mbwm0ytg 70 53 − − NNP cord-017897-mbwm0ytg 70 54 total total JJ cord-017897-mbwm0ytg 70 55 PEEP PEEP NNP cord-017897-mbwm0ytg 70 56 ) ) -RRB- cord-017897-mbwm0ytg 70 57 . . . cord-017897-mbwm0ytg 71 1 Furthermore furthermore RB cord-017897-mbwm0ytg 71 2 in in IN cord-017897-mbwm0ytg 71 3 that that DT cord-017897-mbwm0ytg 71 4 study study NN cord-017897-mbwm0ytg 71 5 was be VBD cord-017897-mbwm0ytg 71 6 demonstrated demonstrate VBN cord-017897-mbwm0ytg 71 7 that that IN cord-017897-mbwm0ytg 71 8 high high JJ cord-017897-mbwm0ytg 71 9 levels level NNS cord-017897-mbwm0ytg 71 10 of of IN cord-017897-mbwm0ytg 71 11 PEEP peep NN cord-017897-mbwm0ytg 71 12 appeared appear VBD cord-017897-mbwm0ytg 71 13 protective protective JJ cord-017897-mbwm0ytg 71 14 only only RB cord-017897-mbwm0ytg 71 15 when when WRB cord-017897-mbwm0ytg 71 16 associated associate VBN cord-017897-mbwm0ytg 71 17 with with IN cord-017897-mbwm0ytg 71 18 reduced reduce VBN cord-017897-mbwm0ytg 71 19 driving driving NN cord-017897-mbwm0ytg 71 20 pressure pressure NN cord-017897-mbwm0ytg 71 21 , , , cord-017897-mbwm0ytg 71 22 with with IN cord-017897-mbwm0ytg 71 23 a a DT cord-017897-mbwm0ytg 71 24 pressure pressure NN cord-017897-mbwm0ytg 71 25 cutoff cutoff NN cord-017897-mbwm0ytg 71 26 of of IN cord-017897-mbwm0ytg 71 27 15 15 CD cord-017897-mbwm0ytg 71 28 cmH cmh NN cord-017897-mbwm0ytg 71 29 2 2 CD cord-017897-mbwm0ytg 71 30 O o NN cord-017897-mbwm0ytg 71 31 [ [ -LRB- cord-017897-mbwm0ytg 71 32 48 48 CD cord-017897-mbwm0ytg 71 33 ] ] -RRB- cord-017897-mbwm0ytg 71 34 . . . cord-017897-mbwm0ytg 72 1 However however RB cord-017897-mbwm0ytg 72 2 , , , cord-017897-mbwm0ytg 72 3 the the DT cord-017897-mbwm0ytg 72 4 use use NN cord-017897-mbwm0ytg 72 5 of of IN cord-017897-mbwm0ytg 72 6 driving drive VBG cord-017897-mbwm0ytg 72 7 pressure pressure NN cord-017897-mbwm0ytg 72 8 has have VBZ cord-017897-mbwm0ytg 72 9 several several JJ cord-017897-mbwm0ytg 72 10 limitations limitation NNS cord-017897-mbwm0ytg 72 11 : : : cord-017897-mbwm0ytg 72 12 the the DT cord-017897-mbwm0ytg 72 13 main main JJ cord-017897-mbwm0ytg 72 14 one one NN cord-017897-mbwm0ytg 72 15 is be VBZ cord-017897-mbwm0ytg 72 16 the the DT cord-017897-mbwm0ytg 72 17 fact fact NN cord-017897-mbwm0ytg 72 18 that that IN cord-017897-mbwm0ytg 72 19 the the DT cord-017897-mbwm0ytg 72 20 pressure pressure NN cord-017897-mbwm0ytg 72 21 that that WDT cord-017897-mbwm0ytg 72 22 extends extend VBZ cord-017897-mbwm0ytg 72 23 the the DT cord-017897-mbwm0ytg 72 24 lung lung NN cord-017897-mbwm0ytg 72 25 is be VBZ cord-017897-mbwm0ytg 72 26 the the DT cord-017897-mbwm0ytg 72 27 transpulmonary transpulmonary NNP cord-017897-mbwm0ytg 72 28 pressure pressure NN cord-017897-mbwm0ytg 72 29 and and CC cord-017897-mbwm0ytg 72 30 not not RB cord-017897-mbwm0ytg 72 31 the the DT cord-017897-mbwm0ytg 72 32 airway airway NN cord-017897-mbwm0ytg 72 33 pressure pressure NN cord-017897-mbwm0ytg 72 34 . . . cord-017897-mbwm0ytg 73 1 Current current JJ cord-017897-mbwm0ytg 73 2 recommendations recommendation NNS cord-017897-mbwm0ytg 73 3 encourage encourage VBP cord-017897-mbwm0ytg 73 4 the the DT cord-017897-mbwm0ytg 73 5 use use NN cord-017897-mbwm0ytg 73 6 , , , cord-017897-mbwm0ytg 73 7 in in IN cord-017897-mbwm0ytg 73 8 mechanically mechanically RB cord-017897-mbwm0ytg 73 9 ventilated ventilate VBN cord-017897-mbwm0ytg 73 10 patients patient NNS cord-017897-mbwm0ytg 73 11 , , , cord-017897-mbwm0ytg 73 12 of of IN cord-017897-mbwm0ytg 73 13 a a DT cord-017897-mbwm0ytg 73 14 conservative conservative JJ cord-017897-mbwm0ytg 73 15 oxygen oxygen NN cord-017897-mbwm0ytg 73 16 strategy strategy NN cord-017897-mbwm0ytg 73 17 with with IN cord-017897-mbwm0ytg 73 18 an an DT cord-017897-mbwm0ytg 73 19 O o NN cord-017897-mbwm0ytg 73 20 2 2 CD cord-017897-mbwm0ytg 73 21 arterial arterial JJ cord-017897-mbwm0ytg 73 22 saturation saturation NN cord-017897-mbwm0ytg 73 23 target target NN cord-017897-mbwm0ytg 73 24 ranging range VBG cord-017897-mbwm0ytg 73 25 from from IN cord-017897-mbwm0ytg 73 26 88 88 CD cord-017897-mbwm0ytg 73 27 % % NN cord-017897-mbwm0ytg 73 28 to to TO cord-017897-mbwm0ytg 73 29 95 95 CD cord-017897-mbwm0ytg 73 30 % % NN cord-017897-mbwm0ytg 73 31 . . . cord-017897-mbwm0ytg 74 1 The the DT cord-017897-mbwm0ytg 74 2 associated associate VBN cord-017897-mbwm0ytg 74 3 use use NN cord-017897-mbwm0ytg 74 4 of of IN cord-017897-mbwm0ytg 74 5 a a DT cord-017897-mbwm0ytg 74 6 " " `` cord-017897-mbwm0ytg 74 7 protective protective JJ cord-017897-mbwm0ytg 74 8 ventilation ventilation NN cord-017897-mbwm0ytg 74 9 , , , cord-017897-mbwm0ytg 74 10 " " '' cord-017897-mbwm0ytg 74 11 with with IN cord-017897-mbwm0ytg 74 12 the the DT cord-017897-mbwm0ytg 74 13 aim aim NN cord-017897-mbwm0ytg 74 14 of of IN cord-017897-mbwm0ytg 74 15 reducing reduce VBG cord-017897-mbwm0ytg 74 16 the the DT cord-017897-mbwm0ytg 74 17 damage damage NN cord-017897-mbwm0ytg 74 18 induced induce VBN cord-017897-mbwm0ytg 74 19 by by IN cord-017897-mbwm0ytg 74 20 ventilation ventilation NN cord-017897-mbwm0ytg 74 21 , , , cord-017897-mbwm0ytg 74 22 can can MD cord-017897-mbwm0ytg 74 23 however however RB cord-017897-mbwm0ytg 74 24 cause cause VB cord-017897-mbwm0ytg 74 25 the the DT cord-017897-mbwm0ytg 74 26 development development NN cord-017897-mbwm0ytg 74 27 of of IN cord-017897-mbwm0ytg 74 28 hypercapnia hypercapnia NN cord-017897-mbwm0ytg 74 29 ; ; : cord-017897-mbwm0ytg 74 30 however however RB cord-017897-mbwm0ytg 74 31 a a DT cord-017897-mbwm0ytg 74 32 PaCO paco NN cord-017897-mbwm0ytg 74 33 2 2 CD cord-017897-mbwm0ytg 74 34 around around IN cord-017897-mbwm0ytg 74 35 70 70 CD cord-017897-mbwm0ytg 74 36 mmHg mmHg NNS cord-017897-mbwm0ytg 74 37 and and CC cord-017897-mbwm0ytg 74 38 a a DT cord-017897-mbwm0ytg 74 39 pH ph NN cord-017897-mbwm0ytg 74 40 of of IN cord-017897-mbwm0ytg 74 41 about about RB cord-017897-mbwm0ytg 74 42 7.20 7.20 CD cord-017897-mbwm0ytg 74 43 have have VBP cord-017897-mbwm0ytg 74 44 been be VBN cord-017897-mbwm0ytg 74 45 proved prove VBN cord-017897-mbwm0ytg 74 46 to to TO cord-017897-mbwm0ytg 74 47 be be VB cord-017897-mbwm0ytg 74 48 safe safe JJ cord-017897-mbwm0ytg 74 49 [ [ -LRB- cord-017897-mbwm0ytg 74 50 49 49 CD cord-017897-mbwm0ytg 74 51 , , , cord-017897-mbwm0ytg 74 52 50 50 CD cord-017897-mbwm0ytg 74 53 ] ] -RRB- cord-017897-mbwm0ytg 74 54 , , , cord-017897-mbwm0ytg 74 55 except except IN cord-017897-mbwm0ytg 74 56 in in IN cord-017897-mbwm0ytg 74 57 special special JJ cord-017897-mbwm0ytg 74 58 cases case NNS cord-017897-mbwm0ytg 74 59 such such JJ cord-017897-mbwm0ytg 74 60 as as IN cord-017897-mbwm0ytg 74 61 patients patient NNS cord-017897-mbwm0ytg 74 62 with with IN cord-017897-mbwm0ytg 74 63 intracranial intracranial JJ cord-017897-mbwm0ytg 74 64 hypertension hypertension NN cord-017897-mbwm0ytg 74 65 or or CC cord-017897-mbwm0ytg 74 66 severe severe JJ cord-017897-mbwm0ytg 74 67 heart heart NN cord-017897-mbwm0ytg 74 68 failure failure NN cord-017897-mbwm0ytg 74 69 . . . cord-017897-mbwm0ytg 75 1 The the DT cord-017897-mbwm0ytg 75 2 rationale rationale NN cord-017897-mbwm0ytg 75 3 for for IN cord-017897-mbwm0ytg 75 4 this this DT cord-017897-mbwm0ytg 75 5 permissive permissive JJ cord-017897-mbwm0ytg 75 6 strategy strategy NN cord-017897-mbwm0ytg 75 7 lies lie VBZ cord-017897-mbwm0ytg 75 8 in in IN cord-017897-mbwm0ytg 75 9 the the DT cord-017897-mbwm0ytg 75 10 known know VBN cord-017897-mbwm0ytg 75 11 effect effect NN cord-017897-mbwm0ytg 75 12 that that WDT cord-017897-mbwm0ytg 75 13 hypercapnic hypercapnic NNP cord-017897-mbwm0ytg 75 14 acidosis acidosis NN cord-017897-mbwm0ytg 75 15 exerts exert VBZ cord-017897-mbwm0ytg 75 16 on on IN cord-017897-mbwm0ytg 75 17 arterial arterial NN cord-017897-mbwm0ytg 75 18 and and CC cord-017897-mbwm0ytg 75 19 tissue tissue NN cord-017897-mbwm0ytg 75 20 oxygenation oxygenation NN cord-017897-mbwm0ytg 75 21 [ [ -LRB- cord-017897-mbwm0ytg 75 22 51 51 CD cord-017897-mbwm0ytg 75 23 ] ] -RRB- cord-017897-mbwm0ytg 75 24 . . . cord-017897-mbwm0ytg 76 1 In in IN cord-017897-mbwm0ytg 76 2 order order NN cord-017897-mbwm0ytg 76 3 to to TO cord-017897-mbwm0ytg 76 4 guarantee guarantee VB cord-017897-mbwm0ytg 76 5 a a DT cord-017897-mbwm0ytg 76 6 better well JJR cord-017897-mbwm0ytg 76 7 patient patient JJ cord-017897-mbwm0ytg 76 8 adaptation adaptation NN cord-017897-mbwm0ytg 76 9 to to IN cord-017897-mbwm0ytg 76 10 the the DT cord-017897-mbwm0ytg 76 11 ventilator ventilator NN cord-017897-mbwm0ytg 76 12 , , , cord-017897-mbwm0ytg 76 13 to to TO cord-017897-mbwm0ytg 76 14 reduce reduce VB cord-017897-mbwm0ytg 76 15 the the DT cord-017897-mbwm0ytg 76 16 oxygen oxygen NN cord-017897-mbwm0ytg 76 17 consumption consumption NN cord-017897-mbwm0ytg 76 18 related relate VBN cord-017897-mbwm0ytg 76 19 to to IN cord-017897-mbwm0ytg 76 20 the the DT cord-017897-mbwm0ytg 76 21 respiratory respiratory JJ cord-017897-mbwm0ytg 76 22 muscle muscle NN cord-017897-mbwm0ytg 76 23 activity activity NN cord-017897-mbwm0ytg 76 24 and and CC cord-017897-mbwm0ytg 76 25 to to TO cord-017897-mbwm0ytg 76 26 guarantee guarantee VB cord-017897-mbwm0ytg 76 27 a a DT cord-017897-mbwm0ytg 76 28 protective protective JJ cord-017897-mbwm0ytg 76 29 transpulmonary transpulmonary JJ cord-017897-mbwm0ytg 76 30 pressure pressure NN cord-017897-mbwm0ytg 76 31 , , , cord-017897-mbwm0ytg 76 32 the the DT cord-017897-mbwm0ytg 76 33 use use NN cord-017897-mbwm0ytg 76 34 of of IN cord-017897-mbwm0ytg 76 35 neuromuscular neuromuscular JJ cord-017897-mbwm0ytg 76 36 blockers blocker NNS cord-017897-mbwm0ytg 76 37 is be VBZ cord-017897-mbwm0ytg 76 38 accepted accept VBN cord-017897-mbwm0ytg 76 39 in in IN cord-017897-mbwm0ytg 76 40 clinical clinical JJ cord-017897-mbwm0ytg 76 41 practice practice NN cord-017897-mbwm0ytg 76 42 [ [ -LRB- cord-017897-mbwm0ytg 76 43 49 49 CD cord-017897-mbwm0ytg 76 44 ] ] -RRB- cord-017897-mbwm0ytg 76 45 . . . cord-017897-mbwm0ytg 77 1 Moreover moreover RB cord-017897-mbwm0ytg 77 2 , , , cord-017897-mbwm0ytg 77 3 neuromuscular neuromuscular NN cord-017897-mbwm0ytg 77 4 blockers blocker NNS cord-017897-mbwm0ytg 77 5 have have VBP cord-017897-mbwm0ytg 77 6 the the DT cord-017897-mbwm0ytg 77 7 ability ability NN cord-017897-mbwm0ytg 77 8 to to TO cord-017897-mbwm0ytg 77 9 reduce reduce VB cord-017897-mbwm0ytg 77 10 stress stress NN cord-017897-mbwm0ytg 77 11 and and CC cord-017897-mbwm0ytg 77 12 strain strain NN cord-017897-mbwm0ytg 77 13 applied apply VBN cord-017897-mbwm0ytg 77 14 to to IN cord-017897-mbwm0ytg 77 15 the the DT cord-017897-mbwm0ytg 77 16 parenchyma parenchyma NN cord-017897-mbwm0ytg 77 17 . . . cord-017897-mbwm0ytg 78 1 Neto Neto NNP cord-017897-mbwm0ytg 78 2 demonstrated demonstrate VBD cord-017897-mbwm0ytg 78 3 that that IN cord-017897-mbwm0ytg 78 4 , , , cord-017897-mbwm0ytg 78 5 in in IN cord-017897-mbwm0ytg 78 6 patients patient NNS cord-017897-mbwm0ytg 78 7 with with IN cord-017897-mbwm0ytg 78 8 severe severe JJ cord-017897-mbwm0ytg 78 9 ARDS ARDS NNP cord-017897-mbwm0ytg 78 10 , , , cord-017897-mbwm0ytg 78 11 a a DT cord-017897-mbwm0ytg 78 12 short short JJ cord-017897-mbwm0ytg 78 13 course course NN cord-017897-mbwm0ytg 78 14 of of IN cord-017897-mbwm0ytg 78 15 treatment treatment NN cord-017897-mbwm0ytg 78 16 with with IN cord-017897-mbwm0ytg 78 17 neuromuscular neuromuscular JJ cord-017897-mbwm0ytg 78 18 blockers blocker NNS cord-017897-mbwm0ytg 78 19 was be VBD cord-017897-mbwm0ytg 78 20 associated associate VBN cord-017897-mbwm0ytg 78 21 with with IN cord-017897-mbwm0ytg 78 22 a a DT cord-017897-mbwm0ytg 78 23 mortality mortality NN cord-017897-mbwm0ytg 78 24 decrease decrease NN cord-017897-mbwm0ytg 78 25 [ [ -LRB- cord-017897-mbwm0ytg 78 26 52 52 CD cord-017897-mbwm0ytg 78 27 ] ] -RRB- cord-017897-mbwm0ytg 78 28 . . . cord-017897-mbwm0ytg 79 1 The the DT cord-017897-mbwm0ytg 79 2 indications indication NNS cord-017897-mbwm0ytg 79 3 for for IN cord-017897-mbwm0ytg 79 4 the the DT cord-017897-mbwm0ytg 79 5 prone prone JJ cord-017897-mbwm0ytg 79 6 positioning positioning NN cord-017897-mbwm0ytg 79 7 have have VBP cord-017897-mbwm0ytg 79 8 changed change VBN cord-017897-mbwm0ytg 79 9 over over IN cord-017897-mbwm0ytg 79 10 time time NN cord-017897-mbwm0ytg 79 11 : : : cord-017897-mbwm0ytg 79 12 once once IN cord-017897-mbwm0ytg 79 13 it -PRON- PRP cord-017897-mbwm0ytg 79 14 was be VBD cord-017897-mbwm0ytg 79 15 used use VBN cord-017897-mbwm0ytg 79 16 to to TO cord-017897-mbwm0ytg 79 17 improve improve VB cord-017897-mbwm0ytg 79 18 arterial arterial JJ cord-017897-mbwm0ytg 79 19 oxygenation oxygenation NN cord-017897-mbwm0ytg 79 20 in in IN cord-017897-mbwm0ytg 79 21 the the DT cord-017897-mbwm0ytg 79 22 most most RBS cord-017897-mbwm0ytg 79 23 severe severe JJ cord-017897-mbwm0ytg 79 24 forms form NNS cord-017897-mbwm0ytg 79 25 of of IN cord-017897-mbwm0ytg 79 26 respiratory respiratory JJ cord-017897-mbwm0ytg 79 27 failure failure NN cord-017897-mbwm0ytg 79 28 [ [ -LRB- cord-017897-mbwm0ytg 79 29 53 53 CD cord-017897-mbwm0ytg 79 30 , , , cord-017897-mbwm0ytg 79 31 54 54 CD cord-017897-mbwm0ytg 79 32 ] ] -RRB- cord-017897-mbwm0ytg 79 33 ; ; : cord-017897-mbwm0ytg 79 34 while while IN cord-017897-mbwm0ytg 79 35 nowadays nowadays RB cord-017897-mbwm0ytg 79 36 it -PRON- PRP cord-017897-mbwm0ytg 79 37 aims aim VBZ cord-017897-mbwm0ytg 79 38 to to TO cord-017897-mbwm0ytg 79 39 achieve achieve VB cord-017897-mbwm0ytg 79 40 a a DT cord-017897-mbwm0ytg 79 41 more more RBR cord-017897-mbwm0ytg 79 42 homogeneous homogeneous JJ cord-017897-mbwm0ytg 79 43 distribution distribution NN cord-017897-mbwm0ytg 79 44 of of IN cord-017897-mbwm0ytg 79 45 stress stress NN cord-017897-mbwm0ytg 79 46 and and CC cord-017897-mbwm0ytg 79 47 strain strain NN cord-017897-mbwm0ytg 79 48 within within IN cord-017897-mbwm0ytg 79 49 the the DT cord-017897-mbwm0ytg 79 50 lung lung NN cord-017897-mbwm0ytg 79 51 parenchyma parenchyma NN cord-017897-mbwm0ytg 79 52 , , , cord-017897-mbwm0ytg 79 53 acting act VBG cord-017897-mbwm0ytg 79 54 in in IN cord-017897-mbwm0ytg 79 55 synergy synergy NN cord-017897-mbwm0ytg 79 56 with with IN cord-017897-mbwm0ytg 79 57 the the DT cord-017897-mbwm0ytg 79 58 remaining remain VBG cord-017897-mbwm0ytg 79 59 therapies therapy NNS cord-017897-mbwm0ytg 79 60 and and CC cord-017897-mbwm0ytg 79 61 protecting protect VBG cord-017897-mbwm0ytg 79 62 against against IN cord-017897-mbwm0ytg 79 63 the the DT cord-017897-mbwm0ytg 79 64 ventilator ventilator NN cord-017897-mbwm0ytg 79 65 induced induce VBN cord-017897-mbwm0ytg 79 66 lung lung NN cord-017897-mbwm0ytg 79 67 injury injury NN cord-017897-mbwm0ytg 79 68 [ [ -LRB- cord-017897-mbwm0ytg 79 69 55 55 CD cord-017897-mbwm0ytg 79 70 ] ] -RRB- cord-017897-mbwm0ytg 79 71 . . . cord-017897-mbwm0ytg 80 1 The the DT cord-017897-mbwm0ytg 80 2 prone prone JJ cord-017897-mbwm0ytg 80 3 positioning positioning NN cord-017897-mbwm0ytg 80 4 improves improve VBZ cord-017897-mbwm0ytg 80 5 ventilation ventilation NN cord-017897-mbwm0ytg 80 6 / / SYM cord-017897-mbwm0ytg 80 7 perfusion perfusion NN cord-017897-mbwm0ytg 80 8 coupling coupling NN cord-017897-mbwm0ytg 80 9 thus thus RB cord-017897-mbwm0ytg 80 10 improving improve VBG cord-017897-mbwm0ytg 80 11 the the DT cord-017897-mbwm0ytg 80 12 CO co NN cord-017897-mbwm0ytg 80 13 2 2 CD cord-017897-mbwm0ytg 80 14 elimination elimination NN cord-017897-mbwm0ytg 80 15 and and CC cord-017897-mbwm0ytg 80 16 improves improve VBZ cord-017897-mbwm0ytg 80 17 the the DT cord-017897-mbwm0ytg 80 18 ventilation ventilation NN cord-017897-mbwm0ytg 80 19 distribution distribution NN cord-017897-mbwm0ytg 80 20 across across IN cord-017897-mbwm0ytg 80 21 the the DT cord-017897-mbwm0ytg 80 22 dorsal dorsal JJ cord-017897-mbwm0ytg 80 23 regions region NNS cord-017897-mbwm0ytg 80 24 of of IN cord-017897-mbwm0ytg 80 25 the the DT cord-017897-mbwm0ytg 80 26 pulmonary pulmonary JJ cord-017897-mbwm0ytg 80 27 parenchyma parenchyma NN cord-017897-mbwm0ytg 80 28 [ [ -LRB- cord-017897-mbwm0ytg 80 29 55 55 CD cord-017897-mbwm0ytg 80 30 , , , cord-017897-mbwm0ytg 80 31 56 56 CD cord-017897-mbwm0ytg 80 32 ] ] -RRB- cord-017897-mbwm0ytg 80 33 . . . cord-017897-mbwm0ytg 81 1 The the DT cord-017897-mbwm0ytg 81 2 association association NN cord-017897-mbwm0ytg 81 3 of of IN cord-017897-mbwm0ytg 81 4 prone prone JJ cord-017897-mbwm0ytg 81 5 positioning positioning NN cord-017897-mbwm0ytg 81 6 and and CC cord-017897-mbwm0ytg 81 7 the the DT cord-017897-mbwm0ytg 81 8 use use NN cord-017897-mbwm0ytg 81 9 of of IN cord-017897-mbwm0ytg 81 10 neuromuscular neuromuscular JJ cord-017897-mbwm0ytg 81 11 blockers blocker NNS cord-017897-mbwm0ytg 81 12 , , , cord-017897-mbwm0ytg 81 13 in in IN cord-017897-mbwm0ytg 81 14 patients patient NNS cord-017897-mbwm0ytg 81 15 with with IN cord-017897-mbwm0ytg 81 16 severe severe JJ cord-017897-mbwm0ytg 81 17 ARDS ARDS NNP cord-017897-mbwm0ytg 81 18 , , , cord-017897-mbwm0ytg 81 19 seems seem VBZ cord-017897-mbwm0ytg 81 20 to to TO cord-017897-mbwm0ytg 81 21 have have VB cord-017897-mbwm0ytg 81 22 a a DT cord-017897-mbwm0ytg 81 23 synergistic synergistic JJ cord-017897-mbwm0ytg 81 24 effect effect NN cord-017897-mbwm0ytg 81 25 on on IN cord-017897-mbwm0ytg 81 26 oxygenation oxygenation NN cord-017897-mbwm0ytg 81 27 and and CC cord-017897-mbwm0ytg 81 28 overall overall JJ cord-017897-mbwm0ytg 81 29 duration duration NN cord-017897-mbwm0ytg 81 30 of of IN cord-017897-mbwm0ytg 81 31 mechanical mechanical JJ cord-017897-mbwm0ytg 81 32 ventilation ventilation NN cord-017897-mbwm0ytg 81 33 and and CC cord-017897-mbwm0ytg 81 34 seems seem VBZ cord-017897-mbwm0ytg 81 35 to to TO cord-017897-mbwm0ytg 81 36 be be VB cord-017897-mbwm0ytg 81 37 associated associate VBN cord-017897-mbwm0ytg 81 38 with with IN cord-017897-mbwm0ytg 81 39 a a DT cord-017897-mbwm0ytg 81 40 better well JJR cord-017897-mbwm0ytg 81 41 outcome outcome NN cord-017897-mbwm0ytg 81 42 . . . cord-017897-mbwm0ytg 82 1 However however RB cord-017897-mbwm0ytg 82 2 , , , cord-017897-mbwm0ytg 82 3 these these DT cord-017897-mbwm0ytg 82 4 data datum NNS cord-017897-mbwm0ytg 82 5 needs need VBZ cord-017897-mbwm0ytg 82 6 further further JJ cord-017897-mbwm0ytg 82 7 studies study NNS cord-017897-mbwm0ytg 82 8 to to TO cord-017897-mbwm0ytg 82 9 confirm confirm VB cord-017897-mbwm0ytg 82 10 . . . cord-017897-mbwm0ytg 83 1 In in IN cord-017897-mbwm0ytg 83 2 any any DT cord-017897-mbwm0ytg 83 3 case case NN cord-017897-mbwm0ytg 83 4 , , , cord-017897-mbwm0ytg 83 5 the the DT cord-017897-mbwm0ytg 83 6 prone prone JJ cord-017897-mbwm0ytg 83 7 positioning positioning NN cord-017897-mbwm0ytg 83 8 presents present VBZ cord-017897-mbwm0ytg 83 9 few few JJ cord-017897-mbwm0ytg 83 10 absolute absolute JJ cord-017897-mbwm0ytg 83 11 contraindications contraindication NNS cord-017897-mbwm0ytg 83 12 , , , cord-017897-mbwm0ytg 83 13 namely namely RB cord-017897-mbwm0ytg 83 14 , , , cord-017897-mbwm0ytg 83 15 pregnancy pregnancy NN cord-017897-mbwm0ytg 83 16 , , , cord-017897-mbwm0ytg 83 17 open open JJ cord-017897-mbwm0ytg 83 18 abdominal abdominal JJ cord-017897-mbwm0ytg 83 19 treatment treatment NN cord-017897-mbwm0ytg 83 20 , , , cord-017897-mbwm0ytg 83 21 unstable unstable JJ cord-017897-mbwm0ytg 83 22 fractures fracture NNS cord-017897-mbwm0ytg 83 23 , , , cord-017897-mbwm0ytg 83 24 and and CC cord-017897-mbwm0ytg 83 25 hemodynamic hemodynamic JJ cord-017897-mbwm0ytg 83 26 instability instability NN cord-017897-mbwm0ytg 83 27 [ [ -LRB- cord-017897-mbwm0ytg 83 28 55 55 CD cord-017897-mbwm0ytg 83 29 ] ] -RRB- cord-017897-mbwm0ytg 83 30 . . . cord-017897-mbwm0ytg 84 1 As as IN cord-017897-mbwm0ytg 84 2 shown show VBN cord-017897-mbwm0ytg 84 3 above above RB cord-017897-mbwm0ytg 84 4 , , , cord-017897-mbwm0ytg 84 5 the the DT cord-017897-mbwm0ytg 84 6 central central JJ cord-017897-mbwm0ytg 84 7 role role NN cord-017897-mbwm0ytg 84 8 in in IN cord-017897-mbwm0ytg 84 9 the the DT cord-017897-mbwm0ytg 84 10 pathogenesis pathogenesis NN cord-017897-mbwm0ytg 84 11 of of IN cord-017897-mbwm0ytg 84 12 ARDS ARDS NNP cord-017897-mbwm0ytg 84 13 is be VBZ cord-017897-mbwm0ytg 84 14 played play VBN cord-017897-mbwm0ytg 84 15 by by IN cord-017897-mbwm0ytg 84 16 the the DT cord-017897-mbwm0ytg 84 17 inflammatory inflammatory JJ cord-017897-mbwm0ytg 84 18 response response NN cord-017897-mbwm0ytg 84 19 that that WDT cord-017897-mbwm0ytg 84 20 develops develop VBZ cord-017897-mbwm0ytg 84 21 in in IN cord-017897-mbwm0ytg 84 22 the the DT cord-017897-mbwm0ytg 84 23 lung lung NN cord-017897-mbwm0ytg 84 24 . . . cord-017897-mbwm0ytg 85 1 Several several JJ cord-017897-mbwm0ytg 85 2 trials trial NNS cord-017897-mbwm0ytg 85 3 have have VBP cord-017897-mbwm0ytg 85 4 been be VBN cord-017897-mbwm0ytg 85 5 performed perform VBN cord-017897-mbwm0ytg 85 6 over over IN cord-017897-mbwm0ytg 85 7 time time NN cord-017897-mbwm0ytg 85 8 to to TO cord-017897-mbwm0ytg 85 9 evaluate evaluate VB cord-017897-mbwm0ytg 85 10 the the DT cord-017897-mbwm0ytg 85 11 use use NN cord-017897-mbwm0ytg 85 12 of of IN cord-017897-mbwm0ytg 85 13 corticosteroids corticosteroid NNS cord-017897-mbwm0ytg 85 14 in in IN cord-017897-mbwm0ytg 85 15 the the DT cord-017897-mbwm0ytg 85 16 treatment treatment NN cord-017897-mbwm0ytg 85 17 of of IN cord-017897-mbwm0ytg 85 18 respiratory respiratory JJ cord-017897-mbwm0ytg 85 19 distress distress NN cord-017897-mbwm0ytg 85 20 syndrome syndrome NN cord-017897-mbwm0ytg 85 21 , , , cord-017897-mbwm0ytg 85 22 but but CC cord-017897-mbwm0ytg 85 23 the the DT cord-017897-mbwm0ytg 85 24 results result NNS cord-017897-mbwm0ytg 85 25 appeared appear VBD cord-017897-mbwm0ytg 85 26 controversial controversial JJ cord-017897-mbwm0ytg 85 27 [ [ -LRB- cord-017897-mbwm0ytg 85 28 57 57 CD cord-017897-mbwm0ytg 85 29 , , , cord-017897-mbwm0ytg 85 30 58 58 CD cord-017897-mbwm0ytg 85 31 ] ] -RRB- cord-017897-mbwm0ytg 85 32 . . . cord-017897-mbwm0ytg 86 1 Meduri Meduri NNP cord-017897-mbwm0ytg 86 2 in in IN cord-017897-mbwm0ytg 86 3 his -PRON- PRP$ cord-017897-mbwm0ytg 86 4 study study NN cord-017897-mbwm0ytg 86 5 carried carry VBD cord-017897-mbwm0ytg 86 6 out out RP cord-017897-mbwm0ytg 86 7 in in IN cord-017897-mbwm0ytg 86 8 the the DT cord-017897-mbwm0ytg 86 9 early early JJ cord-017897-mbwm0ytg 86 10 phases phase NNS cord-017897-mbwm0ytg 86 11 of of IN cord-017897-mbwm0ytg 86 12 the the DT cord-017897-mbwm0ytg 86 13 ARDS ARDS NNP cord-017897-mbwm0ytg 86 14 , , , cord-017897-mbwm0ytg 86 15 showed show VBD cord-017897-mbwm0ytg 86 16 that that IN cord-017897-mbwm0ytg 86 17 the the DT cord-017897-mbwm0ytg 86 18 use use NN cord-017897-mbwm0ytg 86 19 of of IN cord-017897-mbwm0ytg 86 20 a a DT cord-017897-mbwm0ytg 86 21 decremental decremental JJ cord-017897-mbwm0ytg 86 22 infusion infusion NN cord-017897-mbwm0ytg 86 23 scheme scheme NN cord-017897-mbwm0ytg 86 24 of of IN cord-017897-mbwm0ytg 86 25 corticosteroids corticosteroid NNS cord-017897-mbwm0ytg 86 26 leads lead VBZ cord-017897-mbwm0ytg 86 27 to to IN cord-017897-mbwm0ytg 86 28 a a DT cord-017897-mbwm0ytg 86 29 mortality mortality NN cord-017897-mbwm0ytg 86 30 reduction reduction NN cord-017897-mbwm0ytg 86 31 in in IN cord-017897-mbwm0ytg 86 32 intensive intensive JJ cord-017897-mbwm0ytg 86 33 care care NN cord-017897-mbwm0ytg 86 34 [ [ -LRB- cord-017897-mbwm0ytg 86 35 57 57 CD cord-017897-mbwm0ytg 86 36 ] ] -RRB- cord-017897-mbwm0ytg 86 37 . . . cord-017897-mbwm0ytg 87 1 However however RB cord-017897-mbwm0ytg 87 2 , , , cord-017897-mbwm0ytg 87 3 in in IN cord-017897-mbwm0ytg 87 4 other other JJ cord-017897-mbwm0ytg 87 5 studies study NNS cord-017897-mbwm0ytg 87 6 , , , cord-017897-mbwm0ytg 87 7 this this DT cord-017897-mbwm0ytg 87 8 result result NN cord-017897-mbwm0ytg 87 9 has have VBZ cord-017897-mbwm0ytg 87 10 not not RB cord-017897-mbwm0ytg 87 11 been be VBN cord-017897-mbwm0ytg 87 12 confirmed confirm VBN cord-017897-mbwm0ytg 87 13 [ [ -LRB- cord-017897-mbwm0ytg 87 14 58 58 CD cord-017897-mbwm0ytg 87 15 , , , cord-017897-mbwm0ytg 87 16 59 59 CD cord-017897-mbwm0ytg 87 17 ] ] -RRB- cord-017897-mbwm0ytg 87 18 . . . cord-017897-mbwm0ytg 88 1 Although although IN cord-017897-mbwm0ytg 88 2 nitric nitric JJ cord-017897-mbwm0ytg 88 3 oxide oxide NN cord-017897-mbwm0ytg 88 4 ( ( -LRB- cord-017897-mbwm0ytg 88 5 NO no UH cord-017897-mbwm0ytg 88 6 ) ) -RRB- cord-017897-mbwm0ytg 88 7 has have VBZ cord-017897-mbwm0ytg 88 8 a a DT cord-017897-mbwm0ytg 88 9 known know VBN cord-017897-mbwm0ytg 88 10 vasodilatory vasodilatory NN cord-017897-mbwm0ytg 88 11 effect effect NN cord-017897-mbwm0ytg 88 12 on on IN cord-017897-mbwm0ytg 88 13 the the DT cord-017897-mbwm0ytg 88 14 pulmonary pulmonary JJ cord-017897-mbwm0ytg 88 15 vessels vessel NNS cord-017897-mbwm0ytg 88 16 thus thus RB cord-017897-mbwm0ytg 88 17 ensuring ensure VBG cord-017897-mbwm0ytg 88 18 an an DT cord-017897-mbwm0ytg 88 19 improvement improvement NN cord-017897-mbwm0ytg 88 20 of of IN cord-017897-mbwm0ytg 88 21 the the DT cord-017897-mbwm0ytg 88 22 ventilation ventilation NN cord-017897-mbwm0ytg 88 23 / / SYM cord-017897-mbwm0ytg 88 24 perfusion perfusion NN cord-017897-mbwm0ytg 88 25 coupling coupling NN cord-017897-mbwm0ytg 88 26 , , , cord-017897-mbwm0ytg 88 27 its -PRON- PRP$ cord-017897-mbwm0ytg 88 28 use use NN cord-017897-mbwm0ytg 88 29 in in IN cord-017897-mbwm0ytg 88 30 patients patient NNS cord-017897-mbwm0ytg 88 31 with with IN cord-017897-mbwm0ytg 88 32 ARDS ARDS NNP cord-017897-mbwm0ytg 88 33 is be VBZ cord-017897-mbwm0ytg 88 34 not not RB cord-017897-mbwm0ytg 88 35 universally universally RB cord-017897-mbwm0ytg 88 36 accepted accept VBN cord-017897-mbwm0ytg 88 37 [ [ -LRB- cord-017897-mbwm0ytg 88 38 60 60 CD cord-017897-mbwm0ytg 88 39 ] ] -RRB- cord-017897-mbwm0ytg 88 40 . . . cord-017897-mbwm0ytg 89 1 In in IN cord-017897-mbwm0ytg 89 2 fact fact NN cord-017897-mbwm0ytg 89 3 , , , cord-017897-mbwm0ytg 89 4 it -PRON- PRP cord-017897-mbwm0ytg 89 5 has have VBZ cord-017897-mbwm0ytg 89 6 not not RB cord-017897-mbwm0ytg 89 7 been be VBN cord-017897-mbwm0ytg 89 8 clearly clearly RB cord-017897-mbwm0ytg 89 9 demonstrated demonstrate VBN cord-017897-mbwm0ytg 89 10 its -PRON- PRP$ cord-017897-mbwm0ytg 89 11 benefit benefit NN cord-017897-mbwm0ytg 89 12 in in IN cord-017897-mbwm0ytg 89 13 terms term NNS cord-017897-mbwm0ytg 89 14 of of IN cord-017897-mbwm0ytg 89 15 mortality mortality NN cord-017897-mbwm0ytg 89 16 , , , cord-017897-mbwm0ytg 89 17 while while IN cord-017897-mbwm0ytg 89 18 its -PRON- PRP$ cord-017897-mbwm0ytg 89 19 use use NN cord-017897-mbwm0ytg 89 20 is be VBZ cord-017897-mbwm0ytg 89 21 burdened burden VBN cord-017897-mbwm0ytg 89 22 by by IN cord-017897-mbwm0ytg 89 23 possible possible JJ cord-017897-mbwm0ytg 89 24 serious serious JJ cord-017897-mbwm0ytg 89 25 complications complication NNS cord-017897-mbwm0ytg 89 26 , , , cord-017897-mbwm0ytg 89 27 such such JJ cord-017897-mbwm0ytg 89 28 as as IN cord-017897-mbwm0ytg 89 29 renal renal JJ cord-017897-mbwm0ytg 89 30 failure failure NN cord-017897-mbwm0ytg 89 31 [ [ -LRB- cord-017897-mbwm0ytg 89 32 61 61 CD cord-017897-mbwm0ytg 89 33 ] ] -RRB- cord-017897-mbwm0ytg 89 34 . . . cord-017897-mbwm0ytg 90 1 The the DT cord-017897-mbwm0ytg 90 2 use use NN cord-017897-mbwm0ytg 90 3 of of IN cord-017897-mbwm0ytg 90 4 extracorporeal extracorporeal JJ cord-017897-mbwm0ytg 90 5 membrane membrane NN cord-017897-mbwm0ytg 90 6 oxygenation oxygenation NN cord-017897-mbwm0ytg 90 7 ( ( -LRB- cord-017897-mbwm0ytg 90 8 ECMO ECMO NNP cord-017897-mbwm0ytg 90 9 ) ) -RRB- cord-017897-mbwm0ytg 90 10 in in IN cord-017897-mbwm0ytg 90 11 the the DT cord-017897-mbwm0ytg 90 12 treatment treatment NN cord-017897-mbwm0ytg 90 13 of of IN cord-017897-mbwm0ytg 90 14 severe severe JJ cord-017897-mbwm0ytg 90 15 respiratory respiratory JJ cord-017897-mbwm0ytg 90 16 failure failure NN cord-017897-mbwm0ytg 90 17 was be VBD cord-017897-mbwm0ytg 90 18 born bear VBN cord-017897-mbwm0ytg 90 19 around around IN cord-017897-mbwm0ytg 90 20 the the DT cord-017897-mbwm0ytg 90 21 70s 70 NNS cord-017897-mbwm0ytg 90 22 with with IN cord-017897-mbwm0ytg 90 23 the the DT cord-017897-mbwm0ytg 90 24 aim aim NN cord-017897-mbwm0ytg 90 25 of of IN cord-017897-mbwm0ytg 90 26 properly properly RB cord-017897-mbwm0ytg 90 27 oxygenating oxygenate VBG cord-017897-mbwm0ytg 90 28 the the DT cord-017897-mbwm0ytg 90 29 patient patient NN cord-017897-mbwm0ytg 90 30 ensuring ensure VBG cord-017897-mbwm0ytg 90 31 a a DT cord-017897-mbwm0ytg 90 32 protective protective JJ cord-017897-mbwm0ytg 90 33 ventilation ventilation NN cord-017897-mbwm0ytg 90 34 , , , cord-017897-mbwm0ytg 90 35 reducing reduce VBG cord-017897-mbwm0ytg 90 36 the the DT cord-017897-mbwm0ytg 90 37 chances chance NNS cord-017897-mbwm0ytg 90 38 of of IN cord-017897-mbwm0ytg 90 39 lung lung NN cord-017897-mbwm0ytg 90 40 damage damage NN cord-017897-mbwm0ytg 90 41 . . . cord-017897-mbwm0ytg 91 1 Several several JJ cord-017897-mbwm0ytg 91 2 observational observational JJ cord-017897-mbwm0ytg 91 3 studies study NNS cord-017897-mbwm0ytg 91 4 have have VBP cord-017897-mbwm0ytg 91 5 demonstrated demonstrate VBN cord-017897-mbwm0ytg 91 6 various various JJ cord-017897-mbwm0ytg 91 7 ECMO ECMO NNP cord-017897-mbwm0ytg 91 8 's 's POS cord-017897-mbwm0ytg 91 9 benefits benefit NNS cord-017897-mbwm0ytg 91 10 in in IN cord-017897-mbwm0ytg 91 11 patients patient NNS cord-017897-mbwm0ytg 91 12 with with IN cord-017897-mbwm0ytg 91 13 respiratory respiratory JJ cord-017897-mbwm0ytg 91 14 failure failure NN cord-017897-mbwm0ytg 91 15 . . . cord-017897-mbwm0ytg 92 1 However however RB cord-017897-mbwm0ytg 92 2 , , , cord-017897-mbwm0ytg 92 3 the the DT cord-017897-mbwm0ytg 92 4 CESAR CESAR NNP cord-017897-mbwm0ytg 92 5 study study NN cord-017897-mbwm0ytg 92 6 , , , cord-017897-mbwm0ytg 92 7 a a DT cord-017897-mbwm0ytg 92 8 recent recent JJ cord-017897-mbwm0ytg 92 9 randomized randomized JJ cord-017897-mbwm0ytg 92 10 trial trial NN cord-017897-mbwm0ytg 92 11 , , , cord-017897-mbwm0ytg 92 12 showed show VBD cord-017897-mbwm0ytg 92 13 an an DT cord-017897-mbwm0ytg 92 14 increase increase NN cord-017897-mbwm0ytg 92 15 in in IN cord-017897-mbwm0ytg 92 16 survival survival NN cord-017897-mbwm0ytg 92 17 at at IN cord-017897-mbwm0ytg 92 18 6 6 CD cord-017897-mbwm0ytg 92 19 months month NNS cord-017897-mbwm0ytg 92 20 ( ( -LRB- cord-017897-mbwm0ytg 92 21 63 63 CD cord-017897-mbwm0ytg 92 22 % % NN cord-017897-mbwm0ytg 92 23 vs. vs. IN cord-017897-mbwm0ytg 92 24 47 47 CD cord-017897-mbwm0ytg 92 25 % % NN cord-017897-mbwm0ytg 92 26 ) ) -RRB- cord-017897-mbwm0ytg 92 27 but but CC cord-017897-mbwm0ytg 92 28 no no DT cord-017897-mbwm0ytg 92 29 difference difference NN cord-017897-mbwm0ytg 92 30 in in IN cord-017897-mbwm0ytg 92 31 quality quality NN cord-017897-mbwm0ytg 92 32 of of IN cord-017897-mbwm0ytg 92 33 life life NN cord-017897-mbwm0ytg 92 34 and and CC cord-017897-mbwm0ytg 92 35 spirometric spirometric NN cord-017897-mbwm0ytg 92 36 parameters parameter NNS cord-017897-mbwm0ytg 92 37 between between IN cord-017897-mbwm0ytg 92 38 patients patient NNS cord-017897-mbwm0ytg 92 39 undergoing undergo VBG cord-017897-mbwm0ytg 92 40 conventional conventional JJ cord-017897-mbwm0ytg 92 41 mechanical mechanical JJ cord-017897-mbwm0ytg 92 42 ventilation ventilation NN cord-017897-mbwm0ytg 92 43 and and CC cord-017897-mbwm0ytg 92 44 extracorporeal extracorporeal JJ cord-017897-mbwm0ytg 92 45 support support NN cord-017897-mbwm0ytg 92 46 in in IN cord-017897-mbwm0ytg 92 47 reference reference NN cord-017897-mbwm0ytg 92 48 ECMO ecmo NN cord-017897-mbwm0ytg 92 49 centers center NNS cord-017897-mbwm0ytg 92 50 [ [ -LRB- cord-017897-mbwm0ytg 92 51 62 62 CD cord-017897-mbwm0ytg 92 52 ] ] -RRB- cord-017897-mbwm0ytg 92 53 . . . cord-017897-mbwm0ytg 93 1 Therefore therefore RB cord-017897-mbwm0ytg 93 2 , , , cord-017897-mbwm0ytg 93 3 considering consider VBG cord-017897-mbwm0ytg 93 4 the the DT cord-017897-mbwm0ytg 93 5 non non JJ cord-017897-mbwm0ytg 93 6 - - JJ cord-017897-mbwm0ytg 93 7 univocal univocal JJ cord-017897-mbwm0ytg 93 8 interpretation interpretation NN cord-017897-mbwm0ytg 93 9 of of IN cord-017897-mbwm0ytg 93 10 the the DT cord-017897-mbwm0ytg 93 11 data datum NNS cord-017897-mbwm0ytg 93 12 coming come VBG cord-017897-mbwm0ytg 93 13 from from IN cord-017897-mbwm0ytg 93 14 this this DT cord-017897-mbwm0ytg 93 15 trial trial NN cord-017897-mbwm0ytg 93 16 , , , cord-017897-mbwm0ytg 93 17 nowadays nowadays RB cord-017897-mbwm0ytg 93 18 it -PRON- PRP cord-017897-mbwm0ytg 93 19 is be VBZ cord-017897-mbwm0ytg 93 20 not not RB cord-017897-mbwm0ytg 93 21 possible possible JJ cord-017897-mbwm0ytg 93 22 to to TO cord-017897-mbwm0ytg 93 23 conclude conclude VB cord-017897-mbwm0ytg 93 24 for for IN cord-017897-mbwm0ytg 93 25 a a DT cord-017897-mbwm0ytg 93 26 superiority superiority NN cord-017897-mbwm0ytg 93 27 of of IN cord-017897-mbwm0ytg 93 28 ECMO ECMO NNP cord-017897-mbwm0ytg 93 29 support support NN cord-017897-mbwm0ytg 93 30 compared compare VBN cord-017897-mbwm0ytg 93 31 with with IN cord-017897-mbwm0ytg 93 32 the the DT cord-017897-mbwm0ytg 93 33 association association NN cord-017897-mbwm0ytg 93 34 of of IN cord-017897-mbwm0ytg 93 35 the the DT cord-017897-mbwm0ytg 93 36 supportive supportive JJ cord-017897-mbwm0ytg 93 37 therapy therapy NN cord-017897-mbwm0ytg 93 38 listed list VBN cord-017897-mbwm0ytg 93 39 above above IN cord-017897-mbwm0ytg 93 40 [ [ -LRB- cord-017897-mbwm0ytg 93 41 63 63 CD cord-017897-mbwm0ytg 93 42 ] ] -RRB- cord-017897-mbwm0ytg 93 43 . . . cord-017897-mbwm0ytg 94 1 It -PRON- PRP cord-017897-mbwm0ytg 94 2 is be VBZ cord-017897-mbwm0ytg 94 3 of of IN cord-017897-mbwm0ytg 94 4 crucial crucial JJ cord-017897-mbwm0ytg 94 5 importance importance NN cord-017897-mbwm0ytg 94 6 the the DT cord-017897-mbwm0ytg 94 7 choice choice NN cord-017897-mbwm0ytg 94 8 of of IN cord-017897-mbwm0ytg 94 9 the the DT cord-017897-mbwm0ytg 94 10 right right JJ cord-017897-mbwm0ytg 94 11 moment moment NN cord-017897-mbwm0ytg 94 12 to to TO cord-017897-mbwm0ytg 94 13 start start VB cord-017897-mbwm0ytg 94 14 the the DT cord-017897-mbwm0ytg 94 15 weaning weaning NN cord-017897-mbwm0ytg 94 16 from from IN cord-017897-mbwm0ytg 94 17 mechanical mechanical JJ cord-017897-mbwm0ytg 94 18 ventilation ventilation NN cord-017897-mbwm0ytg 94 19 and and CC cord-017897-mbwm0ytg 94 20 to to TO cord-017897-mbwm0ytg 94 21 extubate extubate VB cord-017897-mbwm0ytg 94 22 the the DT cord-017897-mbwm0ytg 94 23 patient patient NN cord-017897-mbwm0ytg 94 24 : : : cord-017897-mbwm0ytg 94 25 any any DT cord-017897-mbwm0ytg 94 26 delay delay NN cord-017897-mbwm0ytg 94 27 in in IN cord-017897-mbwm0ytg 94 28 extubation extubation NN cord-017897-mbwm0ytg 94 29 increases increase VBZ cord-017897-mbwm0ytg 94 30 the the DT cord-017897-mbwm0ytg 94 31 risk risk NN cord-017897-mbwm0ytg 94 32 to to TO cord-017897-mbwm0ytg 94 33 develop develop VB cord-017897-mbwm0ytg 94 34 ventilator ventilator NN cord-017897-mbwm0ytg 94 35 - - HYPH cord-017897-mbwm0ytg 94 36 associated associate VBN cord-017897-mbwm0ytg 94 37 pneumonia pneumonia NN cord-017897-mbwm0ytg 94 38 [ [ -LRB- cord-017897-mbwm0ytg 94 39 64 64 CD cord-017897-mbwm0ytg 94 40 ] ] -RRB- cord-017897-mbwm0ytg 94 41 ; ; : cord-017897-mbwm0ytg 94 42 while while IN cord-017897-mbwm0ytg 94 43 a a DT cord-017897-mbwm0ytg 94 44 premature premature JJ cord-017897-mbwm0ytg 94 45 extubation extubation NN cord-017897-mbwm0ytg 94 46 can can MD cord-017897-mbwm0ytg 94 47 lead lead VB cord-017897-mbwm0ytg 94 48 to to IN cord-017897-mbwm0ytg 94 49 a a DT cord-017897-mbwm0ytg 94 50 prolonged prolonged JJ cord-017897-mbwm0ytg 94 51 stay stay NN cord-017897-mbwm0ytg 94 52 in in IN cord-017897-mbwm0ytg 94 53 ICU ICU NNP cord-017897-mbwm0ytg 94 54 [ [ -LRB- cord-017897-mbwm0ytg 94 55 65 65 CD cord-017897-mbwm0ytg 94 56 ] ] -RRB- cord-017897-mbwm0ytg 95 1 and/or and/or CC cord-017897-mbwm0ytg 95 2 to to IN cord-017897-mbwm0ytg 95 3 a a DT cord-017897-mbwm0ytg 95 4 new new JJ cord-017897-mbwm0ytg 95 5 need need NN cord-017897-mbwm0ytg 95 6 of of IN cord-017897-mbwm0ytg 95 7 invasive invasive JJ cord-017897-mbwm0ytg 95 8 respiratory respiratory JJ cord-017897-mbwm0ytg 95 9 support support NN cord-017897-mbwm0ytg 95 10 . . . cord-017897-mbwm0ytg 96 1 The the DT cord-017897-mbwm0ytg 96 2 weaning weaning NN cord-017897-mbwm0ytg 96 3 from from IN cord-017897-mbwm0ytg 96 4 mechanical mechanical JJ cord-017897-mbwm0ytg 96 5 ventilation ventilation NN cord-017897-mbwm0ytg 96 6 is be VBZ cord-017897-mbwm0ytg 96 7 considered consider VBN cord-017897-mbwm0ytg 96 8 difficult difficult JJ cord-017897-mbwm0ytg 96 9 in in IN cord-017897-mbwm0ytg 96 10 the the DT cord-017897-mbwm0ytg 96 11 20 20 CD cord-017897-mbwm0ytg 96 12 - - SYM cord-017897-mbwm0ytg 96 13 30 30 CD cord-017897-mbwm0ytg 96 14 % % NN cord-017897-mbwm0ytg 96 15 of of IN cord-017897-mbwm0ytg 96 16 mechanical mechanical JJ cord-017897-mbwm0ytg 96 17 - - HYPH cord-017897-mbwm0ytg 96 18 ventilated ventilate VBN cord-017897-mbwm0ytg 96 19 patients patient NNS cord-017897-mbwm0ytg 96 20 : : : cord-017897-mbwm0ytg 96 21 the the DT cord-017897-mbwm0ytg 96 22 failure failure NN cord-017897-mbwm0ytg 96 23 of of IN cord-017897-mbwm0ytg 96 24 the the DT cord-017897-mbwm0ytg 96 25 weaning weaning NN cord-017897-mbwm0ytg 96 26 process process NN cord-017897-mbwm0ytg 96 27 is be VBZ cord-017897-mbwm0ytg 96 28 defined define VBN cord-017897-mbwm0ytg 96 29 as as IN cord-017897-mbwm0ytg 96 30 the the DT cord-017897-mbwm0ytg 96 31 inability inability NN cord-017897-mbwm0ytg 96 32 to to TO cord-017897-mbwm0ytg 96 33 overcome overcome VB cord-017897-mbwm0ytg 96 34 a a DT cord-017897-mbwm0ytg 96 35 spontaneous spontaneous JJ cord-017897-mbwm0ytg 96 36 breathing breathing NN cord-017897-mbwm0ytg 96 37 test test NN cord-017897-mbwm0ytg 96 38 or or CC cord-017897-mbwm0ytg 96 39 as as IN cord-017897-mbwm0ytg 96 40 the the DT cord-017897-mbwm0ytg 96 41 need need NN cord-017897-mbwm0ytg 96 42 for for IN cord-017897-mbwm0ytg 96 43 re re NN cord-017897-mbwm0ytg 96 44 - - NN cord-017897-mbwm0ytg 96 45 intubation intubation NN cord-017897-mbwm0ytg 96 46 within within IN cord-017897-mbwm0ytg 96 47 the the DT cord-017897-mbwm0ytg 96 48 first first JJ cord-017897-mbwm0ytg 96 49 48 48 CD cord-017897-mbwm0ytg 96 50 hours hour NNS cord-017897-mbwm0ytg 96 51 from from IN cord-017897-mbwm0ytg 96 52 the the DT cord-017897-mbwm0ytg 96 53 endotracheal endotracheal NN cord-017897-mbwm0ytg 96 54 tube tube NN cord-017897-mbwm0ytg 96 55 removal removal NN cord-017897-mbwm0ytg 96 56 [ [ -LRB- cord-017897-mbwm0ytg 96 57 66 66 CD cord-017897-mbwm0ytg 96 58 ] ] -RRB- cord-017897-mbwm0ytg 96 59 . . . cord-017897-mbwm0ytg 97 1 The the DT cord-017897-mbwm0ytg 97 2 causes cause NNS cord-017897-mbwm0ytg 97 3 of of IN cord-017897-mbwm0ytg 97 4 weaning wean VBG cord-017897-mbwm0ytg 97 5 failure failure NN cord-017897-mbwm0ytg 97 6 are be VBP cord-017897-mbwm0ytg 97 7 complex complex JJ cord-017897-mbwm0ytg 97 8 and and CC cord-017897-mbwm0ytg 97 9 determined determine VBN cord-017897-mbwm0ytg 97 10 by by IN cord-017897-mbwm0ytg 97 11 different different JJ cord-017897-mbwm0ytg 97 12 factors factor NNS cord-017897-mbwm0ytg 97 13 ; ; : cord-017897-mbwm0ytg 97 14 the the DT cord-017897-mbwm0ytg 97 15 main main JJ cord-017897-mbwm0ytg 97 16 ones one NNS cord-017897-mbwm0ytg 97 17 are be VBP cord-017897-mbwm0ytg 97 18 listed list VBN cord-017897-mbwm0ytg 97 19 below below RB cord-017897-mbwm0ytg 97 20 . . . cord-017897-mbwm0ytg 98 1 In in IN cord-017897-mbwm0ytg 98 2 the the DT cord-017897-mbwm0ytg 98 3 patient patient NN cord-017897-mbwm0ytg 98 4 with with IN cord-017897-mbwm0ytg 98 5 a a DT cord-017897-mbwm0ytg 98 6 difficult difficult JJ cord-017897-mbwm0ytg 98 7 weaning weaning NN cord-017897-mbwm0ytg 98 8 , , , cord-017897-mbwm0ytg 98 9 an an DT cord-017897-mbwm0ytg 98 10 increase increase NN cord-017897-mbwm0ytg 98 11 in in IN cord-017897-mbwm0ytg 98 12 the the DT cord-017897-mbwm0ytg 98 13 airways airway NNS cord-017897-mbwm0ytg 98 14 resistance resistance NN cord-017897-mbwm0ytg 98 15 should should MD cord-017897-mbwm0ytg 98 16 be be VB cord-017897-mbwm0ytg 98 17 considered consider VBN cord-017897-mbwm0ytg 98 18 . . . cord-017897-mbwm0ytg 99 1 Moreover moreover RB cord-017897-mbwm0ytg 99 2 , , , cord-017897-mbwm0ytg 99 3 a a DT cord-017897-mbwm0ytg 99 4 secondary secondary JJ cord-017897-mbwm0ytg 99 5 tracheal tracheal JJ cord-017897-mbwm0ytg 99 6 obstruction obstruction NN cord-017897-mbwm0ytg 99 7 caused cause VBN cord-017897-mbwm0ytg 99 8 by by IN cord-017897-mbwm0ytg 99 9 tracheal tracheal JJ cord-017897-mbwm0ytg 99 10 stenosis stenosis NN cord-017897-mbwm0ytg 99 11 , , , cord-017897-mbwm0ytg 99 12 tracheomalacia tracheomalacia NNP cord-017897-mbwm0ytg 99 13 or or CC cord-017897-mbwm0ytg 99 14 the the DT cord-017897-mbwm0ytg 99 15 development development NN cord-017897-mbwm0ytg 99 16 of of IN cord-017897-mbwm0ytg 99 17 granulation granulation NN cord-017897-mbwm0ytg 99 18 tissue tissue NN cord-017897-mbwm0ytg 99 19 , , , cord-017897-mbwm0ytg 99 20 can can MD cord-017897-mbwm0ytg 99 21 contribute contribute VB cord-017897-mbwm0ytg 99 22 to to IN cord-017897-mbwm0ytg 99 23 a a DT cord-017897-mbwm0ytg 99 24 complicated complicated JJ cord-017897-mbwm0ytg 99 25 weaning weaning NN cord-017897-mbwm0ytg 99 26 from from IN cord-017897-mbwm0ytg 99 27 mechanical mechanical JJ cord-017897-mbwm0ytg 99 28 ventilation ventilation NN cord-017897-mbwm0ytg 99 29 [ [ -LRB- cord-017897-mbwm0ytg 99 30 67 67 CD cord-017897-mbwm0ytg 99 31 ] ] -RRB- cord-017897-mbwm0ytg 99 32 . . . cord-017897-mbwm0ytg 100 1 In in IN cord-017897-mbwm0ytg 100 2 ARDS ARDS NNP cord-017897-mbwm0ytg 100 3 patients patient VBZ cord-017897-mbwm0ytg 100 4 an an DT cord-017897-mbwm0ytg 100 5 increase increase NN cord-017897-mbwm0ytg 100 6 in in IN cord-017897-mbwm0ytg 100 7 airway airway NN cord-017897-mbwm0ytg 100 8 resistances resistance NNS cord-017897-mbwm0ytg 100 9 is be VBZ cord-017897-mbwm0ytg 100 10 typically typically RB cord-017897-mbwm0ytg 100 11 due due JJ cord-017897-mbwm0ytg 100 12 to to IN cord-017897-mbwm0ytg 100 13 bronchial bronchial JJ cord-017897-mbwm0ytg 100 14 walls wall NNS cord-017897-mbwm0ytg 100 15 edema edema NN cord-017897-mbwm0ytg 100 16 of of IN cord-017897-mbwm0ytg 100 17 the the DT cord-017897-mbwm0ytg 100 18 small small JJ cord-017897-mbwm0ytg 100 19 airways airway NNS cord-017897-mbwm0ytg 100 20 . . . cord-017897-mbwm0ytg 101 1 The the DT cord-017897-mbwm0ytg 101 2 delirium delirium NN cord-017897-mbwm0ytg 101 3 seems seem VBZ cord-017897-mbwm0ytg 101 4 to to TO cord-017897-mbwm0ytg 101 5 be be VB cord-017897-mbwm0ytg 101 6 the the DT cord-017897-mbwm0ytg 101 7 more more RBR cord-017897-mbwm0ytg 101 8 frequent frequent JJ cord-017897-mbwm0ytg 101 9 neurological neurological JJ cord-017897-mbwm0ytg 101 10 alteration alteration NN cord-017897-mbwm0ytg 101 11 associated associate VBN cord-017897-mbwm0ytg 101 12 with with IN cord-017897-mbwm0ytg 101 13 a a DT cord-017897-mbwm0ytg 101 14 difficult difficult JJ cord-017897-mbwm0ytg 101 15 weaning weaning NN cord-017897-mbwm0ytg 101 16 , , , cord-017897-mbwm0ytg 101 17 with with IN cord-017897-mbwm0ytg 101 18 a a DT cord-017897-mbwm0ytg 101 19 four four CD cord-017897-mbwm0ytg 101 20 - - HYPH cord-017897-mbwm0ytg 101 21 time time NN cord-017897-mbwm0ytg 101 22 extubation extubation NN cord-017897-mbwm0ytg 101 23 failure failure NN cord-017897-mbwm0ytg 101 24 rate rate NN cord-017897-mbwm0ytg 101 25 than than IN cord-017897-mbwm0ytg 101 26 a a DT cord-017897-mbwm0ytg 101 27 patient patient NN cord-017897-mbwm0ytg 101 28 without without IN cord-017897-mbwm0ytg 101 29 neurological neurological JJ cord-017897-mbwm0ytg 101 30 complications complication NNS cord-017897-mbwm0ytg 101 31 [ [ -LRB- cord-017897-mbwm0ytg 101 32 68 68 CD cord-017897-mbwm0ytg 101 33 ] ] -RRB- cord-017897-mbwm0ytg 101 34 . . . cord-017897-mbwm0ytg 102 1 Delirium delirium NN cord-017897-mbwm0ytg 102 2 diagnosis diagnosis NN cord-017897-mbwm0ytg 102 3 is be VBZ cord-017897-mbwm0ytg 102 4 simple simple JJ cord-017897-mbwm0ytg 102 5 thanks thank NNS cord-017897-mbwm0ytg 102 6 to to IN cord-017897-mbwm0ytg 102 7 the the DT cord-017897-mbwm0ytg 102 8 use use NN cord-017897-mbwm0ytg 102 9 of of IN cord-017897-mbwm0ytg 102 10 validates validate NNS cord-017897-mbwm0ytg 102 11 scales scale NNS cord-017897-mbwm0ytg 102 12 , , , cord-017897-mbwm0ytg 102 13 such such JJ cord-017897-mbwm0ytg 102 14 as as IN cord-017897-mbwm0ytg 102 15 CAM CAM NNP cord-017897-mbwm0ytg 102 16 - - HYPH cord-017897-mbwm0ytg 102 17 ICU ICU NNP cord-017897-mbwm0ytg 102 18 . . . cord-017897-mbwm0ytg 103 1 Psychiatrists psychiatrist NNS cord-017897-mbwm0ytg 103 2 and and CC cord-017897-mbwm0ytg 103 3 psychologists psychologist NNS cord-017897-mbwm0ytg 103 4 could could MD cord-017897-mbwm0ytg 103 5 be be VB cord-017897-mbwm0ytg 103 6 helpful helpful JJ cord-017897-mbwm0ytg 103 7 in in IN cord-017897-mbwm0ytg 103 8 other other JJ cord-017897-mbwm0ytg 103 9 cognitive cognitive JJ cord-017897-mbwm0ytg 103 10 disturbances disturbance NNS cord-017897-mbwm0ytg 103 11 diagnosis diagnosis NN cord-017897-mbwm0ytg 103 12 different different JJ cord-017897-mbwm0ytg 103 13 from from IN cord-017897-mbwm0ytg 103 14 delirium delirium NN cord-017897-mbwm0ytg 103 15 . . . cord-017897-mbwm0ytg 104 1 A a DT cord-017897-mbwm0ytg 104 2 well well RB cord-017897-mbwm0ytg 104 3 - - HYPH cord-017897-mbwm0ytg 104 4 known know VBN cord-017897-mbwm0ytg 104 5 risk risk NN cord-017897-mbwm0ytg 104 6 factor factor NN cord-017897-mbwm0ytg 104 7 for for IN cord-017897-mbwm0ytg 104 8 delirium delirium NN cord-017897-mbwm0ytg 104 9 is be VBZ cord-017897-mbwm0ytg 104 10 represented represent VBN cord-017897-mbwm0ytg 104 11 by by IN cord-017897-mbwm0ytg 104 12 sedation sedation NN cord-017897-mbwm0ytg 104 13 , , , cord-017897-mbwm0ytg 104 14 in in IN cord-017897-mbwm0ytg 104 15 particular particular JJ cord-017897-mbwm0ytg 104 16 when when WRB cord-017897-mbwm0ytg 104 17 midazolam midazolam NNP cord-017897-mbwm0ytg 104 18 is be VBZ cord-017897-mbwm0ytg 104 19 used use VBN cord-017897-mbwm0ytg 104 20 [ [ -LRB- cord-017897-mbwm0ytg 104 21 69 69 CD cord-017897-mbwm0ytg 104 22 ] ] -RRB- cord-017897-mbwm0ytg 104 23 . . . cord-017897-mbwm0ytg 105 1 The the DT cord-017897-mbwm0ytg 105 2 implementation implementation NN cord-017897-mbwm0ytg 105 3 of of IN cord-017897-mbwm0ytg 105 4 a a DT cord-017897-mbwm0ytg 105 5 daily daily JJ cord-017897-mbwm0ytg 105 6 sedative sedative JJ cord-017897-mbwm0ytg 105 7 wash wash NN cord-017897-mbwm0ytg 105 8 - - HYPH cord-017897-mbwm0ytg 105 9 out out RP cord-017897-mbwm0ytg 105 10 protocol protocol NN cord-017897-mbwm0ytg 105 11 , , , cord-017897-mbwm0ytg 105 12 possibly possibly RB cord-017897-mbwm0ytg 105 13 together together RB cord-017897-mbwm0ytg 105 14 with with IN cord-017897-mbwm0ytg 105 15 a a DT cord-017897-mbwm0ytg 105 16 spontaneous spontaneous JJ cord-017897-mbwm0ytg 105 17 breathing breathing NN cord-017897-mbwm0ytg 105 18 trial trial NN cord-017897-mbwm0ytg 105 19 , , , cord-017897-mbwm0ytg 105 20 can can MD cord-017897-mbwm0ytg 105 21 be be VB cord-017897-mbwm0ytg 105 22 associated associate VBN cord-017897-mbwm0ytg 105 23 to to IN cord-017897-mbwm0ytg 105 24 a a DT cord-017897-mbwm0ytg 105 25 reduction reduction NN cord-017897-mbwm0ytg 105 26 in in IN cord-017897-mbwm0ytg 105 27 ventilatory ventilatory JJ cord-017897-mbwm0ytg 105 28 support support NN cord-017897-mbwm0ytg 105 29 length length NN cord-017897-mbwm0ytg 105 30 [ [ -LRB- cord-017897-mbwm0ytg 105 31 70 70 CD cord-017897-mbwm0ytg 105 32 ] ] -RRB- cord-017897-mbwm0ytg 105 33 . . . cord-017897-mbwm0ytg 106 1 The the DT cord-017897-mbwm0ytg 106 2 depression depression NN cord-017897-mbwm0ytg 106 3 development development NN cord-017897-mbwm0ytg 106 4 , , , cord-017897-mbwm0ytg 106 5 common common JJ cord-017897-mbwm0ytg 106 6 in in IN cord-017897-mbwm0ytg 106 7 patients patient NNS cord-017897-mbwm0ytg 106 8 staying stay VBG cord-017897-mbwm0ytg 106 9 in in IN cord-017897-mbwm0ytg 106 10 ICU ICU NNP cord-017897-mbwm0ytg 106 11 for for IN cord-017897-mbwm0ytg 106 12 long long JJ cord-017897-mbwm0ytg 106 13 periods period NNS cord-017897-mbwm0ytg 106 14 , , , cord-017897-mbwm0ytg 106 15 seems seem VBZ cord-017897-mbwm0ytg 106 16 to to TO cord-017897-mbwm0ytg 106 17 be be VB cord-017897-mbwm0ytg 106 18 associated associate VBN cord-017897-mbwm0ytg 106 19 to to IN cord-017897-mbwm0ytg 106 20 an an DT cord-017897-mbwm0ytg 106 21 increased increase VBN cord-017897-mbwm0ytg 106 22 risk risk NN cord-017897-mbwm0ytg 106 23 of of IN cord-017897-mbwm0ytg 106 24 weaning wean VBG cord-017897-mbwm0ytg 106 25 failure failure NN cord-017897-mbwm0ytg 106 26 [ [ -LRB- cord-017897-mbwm0ytg 106 27 71 71 CD cord-017897-mbwm0ytg 106 28 ] ] -RRB- cord-017897-mbwm0ytg 106 29 . . . cord-017897-mbwm0ytg 107 1 Antidepressant antidepressant JJ cord-017897-mbwm0ytg 107 2 drugs drug NNS cord-017897-mbwm0ytg 107 3 seem seem VBP cord-017897-mbwm0ytg 107 4 to to TO cord-017897-mbwm0ytg 107 5 foster foster VB cord-017897-mbwm0ytg 107 6 weaning weaning NN cord-017897-mbwm0ytg 107 7 from from IN cord-017897-mbwm0ytg 107 8 mechanical mechanical JJ cord-017897-mbwm0ytg 107 9 ventilation ventilation NN cord-017897-mbwm0ytg 107 10 , , , cord-017897-mbwm0ytg 107 11 even even RB cord-017897-mbwm0ytg 107 12 if if IN cord-017897-mbwm0ytg 107 13 only only RB cord-017897-mbwm0ytg 107 14 few few JJ cord-017897-mbwm0ytg 107 15 data datum NNS cord-017897-mbwm0ytg 107 16 are be VBP cord-017897-mbwm0ytg 107 17 available available JJ cord-017897-mbwm0ytg 107 18 at at IN cord-017897-mbwm0ytg 107 19 the the DT cord-017897-mbwm0ytg 107 20 moment moment NN cord-017897-mbwm0ytg 107 21 [ [ -LRB- cord-017897-mbwm0ytg 107 22 72 72 CD cord-017897-mbwm0ytg 107 23 ] ] -RRB- cord-017897-mbwm0ytg 107 24 . . . cord-017897-mbwm0ytg 108 1 In in IN cord-017897-mbwm0ytg 108 2 the the DT cord-017897-mbwm0ytg 108 3 patient patient NN cord-017897-mbwm0ytg 108 4 affected affect VBN cord-017897-mbwm0ytg 108 5 by by IN cord-017897-mbwm0ytg 108 6 an an DT cord-017897-mbwm0ytg 108 7 alteration alteration NN cord-017897-mbwm0ytg 108 8 of of IN cord-017897-mbwm0ytg 108 9 the the DT cord-017897-mbwm0ytg 108 10 myocardial myocardial JJ cord-017897-mbwm0ytg 108 11 contractility contractility NN cord-017897-mbwm0ytg 108 12 , , , cord-017897-mbwm0ytg 108 13 the the DT cord-017897-mbwm0ytg 108 14 shift shift NN cord-017897-mbwm0ytg 108 15 from from IN cord-017897-mbwm0ytg 108 16 mechanical mechanical JJ cord-017897-mbwm0ytg 108 17 ventilation ventilation NN cord-017897-mbwm0ytg 108 18 to to IN cord-017897-mbwm0ytg 108 19 spontaneous spontaneous JJ cord-017897-mbwm0ytg 108 20 breathing breathing NN cord-017897-mbwm0ytg 108 21 causes cause VBZ cord-017897-mbwm0ytg 108 22 an an DT cord-017897-mbwm0ytg 108 23 increase increase NN cord-017897-mbwm0ytg 108 24 in in IN cord-017897-mbwm0ytg 108 25 the the DT cord-017897-mbwm0ytg 108 26 cardiovascular cardiovascular JJ cord-017897-mbwm0ytg 108 27 work work NN cord-017897-mbwm0ytg 108 28 , , , cord-017897-mbwm0ytg 108 29 mainly mainly RB cord-017897-mbwm0ytg 108 30 due due IN cord-017897-mbwm0ytg 108 31 to to IN cord-017897-mbwm0ytg 108 32 two two CD cord-017897-mbwm0ytg 108 33 factors factor NNS cord-017897-mbwm0ytg 108 34 : : : cord-017897-mbwm0ytg 108 35 an an DT cord-017897-mbwm0ytg 108 36 intrathoracic intrathoracic JJ cord-017897-mbwm0ytg 108 37 pressure pressure NN cord-017897-mbwm0ytg 108 38 variation variation NN cord-017897-mbwm0ytg 108 39 that that WDT cord-017897-mbwm0ytg 108 40 causes cause VBZ cord-017897-mbwm0ytg 108 41 changes change NNS cord-017897-mbwm0ytg 108 42 in in IN cord-017897-mbwm0ytg 108 43 preload preload NN cord-017897-mbwm0ytg 108 44 and and CC cord-017897-mbwm0ytg 108 45 afterload afterload NN cord-017897-mbwm0ytg 108 46 and and CC cord-017897-mbwm0ytg 108 47 an an DT cord-017897-mbwm0ytg 108 48 increase increase NN cord-017897-mbwm0ytg 108 49 of of IN cord-017897-mbwm0ytg 108 50 the the DT cord-017897-mbwm0ytg 108 51 oxygen oxygen NN cord-017897-mbwm0ytg 108 52 consumption consumption NN cord-017897-mbwm0ytg 108 53 by by IN cord-017897-mbwm0ytg 108 54 respiratory respiratory JJ cord-017897-mbwm0ytg 108 55 muscles muscle NNS cord-017897-mbwm0ytg 108 56 [ [ -LRB- cord-017897-mbwm0ytg 108 57 73 73 CD cord-017897-mbwm0ytg 108 58 ] ] -RRB- cord-017897-mbwm0ytg 108 59 . . . cord-017897-mbwm0ytg 109 1 An an DT cord-017897-mbwm0ytg 109 2 accurate accurate JJ cord-017897-mbwm0ytg 109 3 cardiovascular cardiovascular JJ cord-017897-mbwm0ytg 109 4 evaluation evaluation NN cord-017897-mbwm0ytg 109 5 in in IN cord-017897-mbwm0ytg 109 6 mechanically mechanically RB cord-017897-mbwm0ytg 109 7 ventilated ventilate VBN cord-017897-mbwm0ytg 109 8 patients patient NNS cord-017897-mbwm0ytg 109 9 makes make VBZ cord-017897-mbwm0ytg 109 10 the the DT cord-017897-mbwm0ytg 109 11 introduction introduction NN cord-017897-mbwm0ytg 109 12 or or CC cord-017897-mbwm0ytg 109 13 the the DT cord-017897-mbwm0ytg 109 14 optimization optimization NN cord-017897-mbwm0ytg 109 15 of of IN cord-017897-mbwm0ytg 109 16 the the DT cord-017897-mbwm0ytg 109 17 appropriate appropriate JJ cord-017897-mbwm0ytg 109 18 therapy therapy NN cord-017897-mbwm0ytg 109 19 possible possible JJ cord-017897-mbwm0ytg 109 20 : : : cord-017897-mbwm0ytg 109 21 this this DT cord-017897-mbwm0ytg 109 22 allows allow VBZ cord-017897-mbwm0ytg 109 23 a a DT cord-017897-mbwm0ytg 109 24 reduction reduction NN cord-017897-mbwm0ytg 109 25 of of IN cord-017897-mbwm0ytg 109 26 the the DT cord-017897-mbwm0ytg 109 27 weaning weaning NN cord-017897-mbwm0ytg 109 28 failure failure NN cord-017897-mbwm0ytg 109 29 risk risk NN cord-017897-mbwm0ytg 109 30 . . . cord-017897-mbwm0ytg 110 1 The the DT cord-017897-mbwm0ytg 110 2 beginning beginning NN cord-017897-mbwm0ytg 110 3 of of IN cord-017897-mbwm0ytg 110 4 weaning weaning NN cord-017897-mbwm0ytg 110 5 causes cause VBZ cord-017897-mbwm0ytg 110 6 an an DT cord-017897-mbwm0ytg 110 7 increase increase NN cord-017897-mbwm0ytg 110 8 in in IN cord-017897-mbwm0ytg 110 9 respiratory respiratory JJ cord-017897-mbwm0ytg 110 10 muscle muscle NN cord-017897-mbwm0ytg 110 11 workload workload NN cord-017897-mbwm0ytg 110 12 that that WDT cord-017897-mbwm0ytg 110 13 frequently frequently RB cord-017897-mbwm0ytg 110 14 appears appear VBZ cord-017897-mbwm0ytg 110 15 to to TO cord-017897-mbwm0ytg 110 16 be be VB cord-017897-mbwm0ytg 110 17 already already RB cord-017897-mbwm0ytg 110 18 weakened weaken VBN cord-017897-mbwm0ytg 110 19 . . . cord-017897-mbwm0ytg 111 1 In in IN cord-017897-mbwm0ytg 111 2 assessing assess VBG cord-017897-mbwm0ytg 111 3 the the DT cord-017897-mbwm0ytg 111 4 cause cause NN cord-017897-mbwm0ytg 111 5 of of IN cord-017897-mbwm0ytg 111 6 muscle muscle NN cord-017897-mbwm0ytg 111 7 weakness weakness NN cord-017897-mbwm0ytg 111 8 , , , cord-017897-mbwm0ytg 111 9 it -PRON- PRP cord-017897-mbwm0ytg 111 10 is be VBZ cord-017897-mbwm0ytg 111 11 important important JJ cord-017897-mbwm0ytg 111 12 to to TO cord-017897-mbwm0ytg 111 13 bear bear VB cord-017897-mbwm0ytg 111 14 in in IN cord-017897-mbwm0ytg 111 15 mind mind NN cord-017897-mbwm0ytg 111 16 that that IN cord-017897-mbwm0ytg 111 17 the the DT cord-017897-mbwm0ytg 111 18 respiratory respiratory JJ cord-017897-mbwm0ytg 111 19 muscle muscle NN cord-017897-mbwm0ytg 111 20 dysfunction dysfunction NN cord-017897-mbwm0ytg 111 21 can can MD cord-017897-mbwm0ytg 111 22 result result VB cord-017897-mbwm0ytg 111 23 from from IN cord-017897-mbwm0ytg 111 24 a a DT cord-017897-mbwm0ytg 111 25 damage damage NN cord-017897-mbwm0ytg 111 26 located locate VBN cord-017897-mbwm0ytg 111 27 anywhere anywhere RB cord-017897-mbwm0ytg 111 28 on on IN cord-017897-mbwm0ytg 111 29 the the DT cord-017897-mbwm0ytg 111 30 axis axis NN cord-017897-mbwm0ytg 111 31 from from IN cord-017897-mbwm0ytg 111 32 the the DT cord-017897-mbwm0ytg 111 33 afferent afferent JJ cord-017897-mbwm0ytg 111 34 chemoreceptors chemoreceptor NNS cord-017897-mbwm0ytg 111 35 , , , cord-017897-mbwm0ytg 111 36 to to IN cord-017897-mbwm0ytg 111 37 the the DT cord-017897-mbwm0ytg 111 38 respiratory respiratory JJ cord-017897-mbwm0ytg 111 39 center center NN cord-017897-mbwm0ytg 111 40 , , , cord-017897-mbwm0ytg 111 41 to to IN cord-017897-mbwm0ytg 111 42 the the DT cord-017897-mbwm0ytg 111 43 single single JJ cord-017897-mbwm0ytg 111 44 muscle muscle NN cord-017897-mbwm0ytg 111 45 fiber fiber NN cord-017897-mbwm0ytg 111 46 [ [ -LRB- cord-017897-mbwm0ytg 111 47 73 73 CD cord-017897-mbwm0ytg 111 48 ] ] -RRB- cord-017897-mbwm0ytg 111 49 . . . cord-017897-mbwm0ytg 112 1 The the DT cord-017897-mbwm0ytg 112 2 cause cause NN cord-017897-mbwm0ytg 112 3 of of IN cord-017897-mbwm0ytg 112 4 the the DT cord-017897-mbwm0ytg 112 5 failure failure NN cord-017897-mbwm0ytg 112 6 is be VBZ cord-017897-mbwm0ytg 112 7 frequently frequently RB cord-017897-mbwm0ytg 112 8 represented represent VBN cord-017897-mbwm0ytg 112 9 by by IN cord-017897-mbwm0ytg 112 10 a a DT cord-017897-mbwm0ytg 112 11 diaphragm diaphragm NN cord-017897-mbwm0ytg 112 12 alteration alteration NN cord-017897-mbwm0ytg 112 13 that that WDT cord-017897-mbwm0ytg 112 14 can can MD cord-017897-mbwm0ytg 112 15 be be VB cord-017897-mbwm0ytg 112 16 secondary secondary JJ cord-017897-mbwm0ytg 112 17 to to IN cord-017897-mbwm0ytg 112 18 two two CD cord-017897-mbwm0ytg 112 19 conditions condition NNS cord-017897-mbwm0ytg 112 20 that that WDT cord-017897-mbwm0ytg 112 21 often often RB cord-017897-mbwm0ytg 112 22 coexist coexist VBP cord-017897-mbwm0ytg 112 23 in in IN cord-017897-mbwm0ytg 112 24 the the DT cord-017897-mbwm0ytg 112 25 same same JJ cord-017897-mbwm0ytg 112 26 patient patient NN cord-017897-mbwm0ytg 112 27 : : : cord-017897-mbwm0ytg 112 28 the the DT cord-017897-mbwm0ytg 112 29 critical critical JJ cord-017897-mbwm0ytg 112 30 illness illness NN cord-017897-mbwm0ytg 112 31 polyneuropathy polyneuropathy NN cord-017897-mbwm0ytg 112 32 ( ( -LRB- cord-017897-mbwm0ytg 112 33 CIP CIP NNP cord-017897-mbwm0ytg 112 34 ) ) -RRB- cord-017897-mbwm0ytg 112 35 involving involve VBG cord-017897-mbwm0ytg 112 36 the the DT cord-017897-mbwm0ytg 112 37 phrenic phrenic JJ cord-017897-mbwm0ytg 112 38 nerve nerve NN cord-017897-mbwm0ytg 112 39 and and CC cord-017897-mbwm0ytg 112 40 , , , cord-017897-mbwm0ytg 112 41 more more RBR cord-017897-mbwm0ytg 112 42 often often RB cord-017897-mbwm0ytg 112 43 , , , cord-017897-mbwm0ytg 112 44 the the DT cord-017897-mbwm0ytg 112 45 critical critical JJ cord-017897-mbwm0ytg 112 46 illness illness NN cord-017897-mbwm0ytg 112 47 myopathy myopathy NN cord-017897-mbwm0ytg 112 48 ( ( -LRB- cord-017897-mbwm0ytg 112 49 CIM CIM NNP cord-017897-mbwm0ytg 112 50 ) ) -RRB- cord-017897-mbwm0ytg 112 51 . . . cord-017897-mbwm0ytg 113 1 Several several JJ cord-017897-mbwm0ytg 113 2 works work NNS cord-017897-mbwm0ytg 113 3 have have VBP cord-017897-mbwm0ytg 113 4 demonstrated demonstrate VBN cord-017897-mbwm0ytg 113 5 that that IN cord-017897-mbwm0ytg 113 6 in in IN cord-017897-mbwm0ytg 113 7 mechanicalventilated mechanicalventilate VBN cord-017897-mbwm0ytg 113 8 patients patient NNS cord-017897-mbwm0ytg 113 9 , , , cord-017897-mbwm0ytg 113 10 there there EX cord-017897-mbwm0ytg 113 11 is be VBZ cord-017897-mbwm0ytg 113 12 often often RB cord-017897-mbwm0ytg 113 13 an an DT cord-017897-mbwm0ytg 113 14 alteration alteration NN cord-017897-mbwm0ytg 113 15 of of IN cord-017897-mbwm0ytg 113 16 the the DT cord-017897-mbwm0ytg 113 17 respiratory respiratory JJ cord-017897-mbwm0ytg 113 18 muscle muscle NN cord-017897-mbwm0ytg 113 19 contractility contractility NN cord-017897-mbwm0ytg 113 20 [ [ -LRB- cord-017897-mbwm0ytg 113 21 74 74 CD cord-017897-mbwm0ytg 113 22 ] ] -RRB- cord-017897-mbwm0ytg 113 23 . . . cord-017897-mbwm0ytg 114 1 Before before IN cord-017897-mbwm0ytg 114 2 implementing implement VBG cord-017897-mbwm0ytg 114 3 weaning weaning NN cord-017897-mbwm0ytg 114 4 - - HYPH cord-017897-mbwm0ytg 114 5 from from IN cord-017897-mbwm0ytg 114 6 - - HYPH cord-017897-mbwm0ytg 114 7 mechanical mechanical JJ cord-017897-mbwm0ytg 114 8 - - HYPH cord-017897-mbwm0ytg 114 9 ventilation ventilation NN cord-017897-mbwm0ytg 114 10 protocols protocol NNS cord-017897-mbwm0ytg 114 11 , , , cord-017897-mbwm0ytg 114 12 it -PRON- PRP cord-017897-mbwm0ytg 114 13 is be VBZ cord-017897-mbwm0ytg 114 14 necessary necessary JJ cord-017897-mbwm0ytg 114 15 to to TO cord-017897-mbwm0ytg 114 16 carefully carefully RB cord-017897-mbwm0ytg 114 17 assess assess VB cord-017897-mbwm0ytg 114 18 the the DT cord-017897-mbwm0ytg 114 19 diaphragmatic diaphragmatic JJ cord-017897-mbwm0ytg 114 20 function function NN cord-017897-mbwm0ytg 114 21 so so IN cord-017897-mbwm0ytg 114 22 as as IN cord-017897-mbwm0ytg 114 23 to to TO cord-017897-mbwm0ytg 114 24 exclude exclude VB cord-017897-mbwm0ytg 114 25 the the DT cord-017897-mbwm0ytg 114 26 presence presence NN cord-017897-mbwm0ytg 114 27 of of IN cord-017897-mbwm0ytg 114 28 alterations alteration NNS cord-017897-mbwm0ytg 114 29 . . . cord-017897-mbwm0ytg 115 1 To to TO cord-017897-mbwm0ytg 115 2 do do VB cord-017897-mbwm0ytg 115 3 so so RB cord-017897-mbwm0ytg 115 4 , , , cord-017897-mbwm0ytg 115 5 some some DT cord-017897-mbwm0ytg 115 6 tests test NNS cord-017897-mbwm0ytg 115 7 used use VBN cord-017897-mbwm0ytg 115 8 in in IN cord-017897-mbwm0ytg 115 9 clinical clinical JJ cord-017897-mbwm0ytg 115 10 practice practice NN cord-017897-mbwm0ytg 115 11 are be VBP cord-017897-mbwm0ytg 115 12 here here RB cord-017897-mbwm0ytg 115 13 below below RB cord-017897-mbwm0ytg 115 14 displayed display VBN cord-017897-mbwm0ytg 115 15 . . . cord-017897-mbwm0ytg 116 1 • • NNP cord-017897-mbwm0ytg 117 1 P p NN cord-017897-mbwm0ytg 117 2 0.1 0.1 CD cord-017897-mbwm0ytg 118 1 : : : cord-017897-mbwm0ytg 118 2 it -PRON- PRP cord-017897-mbwm0ytg 118 3 is be VBZ cord-017897-mbwm0ytg 118 4 the the DT cord-017897-mbwm0ytg 118 5 most most RBS cord-017897-mbwm0ytg 118 6 frequently frequently RB cord-017897-mbwm0ytg 118 7 used use VBN cord-017897-mbwm0ytg 118 8 test test NN cord-017897-mbwm0ytg 118 9 for for IN cord-017897-mbwm0ytg 118 10 the the DT cord-017897-mbwm0ytg 118 11 respiratory respiratory JJ cord-017897-mbwm0ytg 118 12 drive drive NN cord-017897-mbwm0ytg 118 13 evaluation evaluation NN cord-017897-mbwm0ytg 118 14 in in IN cord-017897-mbwm0ytg 118 15 mechanically mechanically RB cord-017897-mbwm0ytg 118 16 ventilated ventilate VBN cord-017897-mbwm0ytg 118 17 patients patient NNS cord-017897-mbwm0ytg 118 18 . . . cord-017897-mbwm0ytg 119 1 In in IN cord-017897-mbwm0ytg 119 2 order order NN cord-017897-mbwm0ytg 119 3 to to TO cord-017897-mbwm0ytg 119 4 carry carry VB cord-017897-mbwm0ytg 119 5 out out RP cord-017897-mbwm0ytg 119 6 this this DT cord-017897-mbwm0ytg 119 7 test test NN cord-017897-mbwm0ytg 119 8 , , , cord-017897-mbwm0ytg 119 9 the the DT cord-017897-mbwm0ytg 119 10 ventilator ventilator NN cord-017897-mbwm0ytg 119 11 's 's POS cord-017897-mbwm0ytg 119 12 inspiratory inspiratory JJ cord-017897-mbwm0ytg 119 13 valve valve NN cord-017897-mbwm0ytg 119 14 is be VBZ cord-017897-mbwm0ytg 119 15 closed close VBN cord-017897-mbwm0ytg 119 16 , , , cord-017897-mbwm0ytg 119 17 and and CC cord-017897-mbwm0ytg 119 18 the the DT cord-017897-mbwm0ytg 119 19 pressure pressure NN cord-017897-mbwm0ytg 119 20 fall fall VBP cord-017897-mbwm0ytg 119 21 within within IN cord-017897-mbwm0ytg 119 22 the the DT cord-017897-mbwm0ytg 119 23 first first JJ cord-017897-mbwm0ytg 119 24 100 100 CD cord-017897-mbwm0ytg 119 25 msec msec NNS cord-017897-mbwm0ytg 119 26 after after IN cord-017897-mbwm0ytg 119 27 the the DT cord-017897-mbwm0ytg 119 28 patient patient NN cord-017897-mbwm0ytg 119 29 's 's POS cord-017897-mbwm0ytg 119 30 inspiratory inspiratory JJ cord-017897-mbwm0ytg 119 31 attempt attempt NN cord-017897-mbwm0ytg 119 32 is be VBZ cord-017897-mbwm0ytg 119 33 recorded record VBN cord-017897-mbwm0ytg 119 34 . . . cord-017897-mbwm0ytg 120 1 Usually usually RB cord-017897-mbwm0ytg 120 2 , , , cord-017897-mbwm0ytg 120 3 the the DT cord-017897-mbwm0ytg 120 4 P p NN cord-017897-mbwm0ytg 120 5 0.1 0.1 CD cord-017897-mbwm0ytg 120 6 value value NN cord-017897-mbwm0ytg 120 7 varies vary VBZ cord-017897-mbwm0ytg 120 8 between between IN cord-017897-mbwm0ytg 120 9 0.5 0.5 CD cord-017897-mbwm0ytg 120 10 and and CC cord-017897-mbwm0ytg 120 11 1.5 1.5 CD cord-017897-mbwm0ytg 120 12 cmH cmh NN cord-017897-mbwm0ytg 120 13 2 2 CD cord-017897-mbwm0ytg 121 1 O. O. NNP cord-017897-mbwm0ytg 122 1 It -PRON- PRP cord-017897-mbwm0ytg 122 2 is be VBZ cord-017897-mbwm0ytg 122 3 important important JJ cord-017897-mbwm0ytg 122 4 to to TO cord-017897-mbwm0ytg 122 5 note note VB cord-017897-mbwm0ytg 122 6 that that IN cord-017897-mbwm0ytg 122 7 this this DT cord-017897-mbwm0ytg 122 8 parameter parameter NN cord-017897-mbwm0ytg 122 9 depends depend VBZ cord-017897-mbwm0ytg 122 10 both both DT cord-017897-mbwm0ytg 122 11 on on IN cord-017897-mbwm0ytg 122 12 the the DT cord-017897-mbwm0ytg 122 13 inspiratory inspiratory JJ cord-017897-mbwm0ytg 122 14 muscular muscular JJ cord-017897-mbwm0ytg 122 15 strength strength NN cord-017897-mbwm0ytg 122 16 and and CC cord-017897-mbwm0ytg 122 17 on on IN cord-017897-mbwm0ytg 122 18 the the DT cord-017897-mbwm0ytg 122 19 respiratory respiratory JJ cord-017897-mbwm0ytg 122 20 drive drive NN cord-017897-mbwm0ytg 122 21 . . . cord-017897-mbwm0ytg 123 1 • • NNP cord-017897-mbwm0ytg 124 1 Maximal maximal JJ cord-017897-mbwm0ytg 124 2 inspiratory inspiratory JJ cord-017897-mbwm0ytg 124 3 pressure pressure NN cord-017897-mbwm0ytg 124 4 ( ( -LRB- cord-017897-mbwm0ytg 124 5 MIP MIP NNP cord-017897-mbwm0ytg 124 6 ) ) -RRB- cord-017897-mbwm0ytg 124 7 : : : cord-017897-mbwm0ytg 124 8 represents represent VBZ cord-017897-mbwm0ytg 124 9 the the DT cord-017897-mbwm0ytg 124 10 maximum maximum JJ cord-017897-mbwm0ytg 124 11 pressure pressure NN cord-017897-mbwm0ytg 124 12 that that WDT cord-017897-mbwm0ytg 124 13 the the DT cord-017897-mbwm0ytg 124 14 patient patient NN cord-017897-mbwm0ytg 124 15 can can MD cord-017897-mbwm0ytg 124 16 generate generate VB cord-017897-mbwm0ytg 124 17 by by IN cord-017897-mbwm0ytg 124 18 inhaling inhale VBG cord-017897-mbwm0ytg 124 19 against against IN cord-017897-mbwm0ytg 124 20 a a DT cord-017897-mbwm0ytg 124 21 completely completely RB cord-017897-mbwm0ytg 124 22 occluded occlude VBN cord-017897-mbwm0ytg 124 23 airway airway NN cord-017897-mbwm0ytg 124 24 , , , cord-017897-mbwm0ytg 124 25 starting start VBG cord-017897-mbwm0ytg 124 26 from from IN cord-017897-mbwm0ytg 124 27 functional functional JJ cord-017897-mbwm0ytg 124 28 residual residual JJ cord-017897-mbwm0ytg 124 29 capacity capacity NN cord-017897-mbwm0ytg 124 30 ( ( -LRB- cord-017897-mbwm0ytg 124 31 FRC FRC NNP cord-017897-mbwm0ytg 124 32 ) ) -RRB- cord-017897-mbwm0ytg 124 33 . . . cord-017897-mbwm0ytg 125 1 The the DT cord-017897-mbwm0ytg 125 2 minimum minimum JJ cord-017897-mbwm0ytg 125 3 thresholds threshold NNS cord-017897-mbwm0ytg 125 4 are be VBP cord-017897-mbwm0ytg 125 5 -75 -75 NN cord-017897-mbwm0ytg 125 6 cmH cmh NN cord-017897-mbwm0ytg 125 7 2 2 CD cord-017897-mbwm0ytg 125 8 O o NN cord-017897-mbwm0ytg 125 9 for for IN cord-017897-mbwm0ytg 125 10 men man NNS cord-017897-mbwm0ytg 125 11 and and CC cord-017897-mbwm0ytg 126 1 -50 -50 NNP cord-017897-mbwm0ytg 126 2 cmH cmH NNP cord-017897-mbwm0ytg 127 1 2 2 LS cord-017897-mbwm0ytg 127 2 O o NN cord-017897-mbwm0ytg 127 3 for for IN cord-017897-mbwm0ytg 127 4 women woman NNS cord-017897-mbwm0ytg 127 5 [ [ -LRB- cord-017897-mbwm0ytg 127 6 75 75 CD cord-017897-mbwm0ytg 127 7 ] ] -RRB- cord-017897-mbwm0ytg 127 8 . . . cord-017897-mbwm0ytg 128 1 Theoretically theoretically RB cord-017897-mbwm0ytg 128 2 , , , cord-017897-mbwm0ytg 128 3 the the DT cord-017897-mbwm0ytg 128 4 most most RBS cord-017897-mbwm0ytg 128 5 negative negative JJ cord-017897-mbwm0ytg 128 6 values value NNS cord-017897-mbwm0ytg 128 7 exclude exclude VBP cord-017897-mbwm0ytg 128 8 the the DT cord-017897-mbwm0ytg 128 9 presence presence NN cord-017897-mbwm0ytg 128 10 of of IN cord-017897-mbwm0ytg 128 11 a a DT cord-017897-mbwm0ytg 128 12 significant significant JJ cord-017897-mbwm0ytg 128 13 muscular muscular JJ cord-017897-mbwm0ytg 128 14 weakness weakness NN cord-017897-mbwm0ytg 128 15 . . . cord-017897-mbwm0ytg 129 1 • • NNP cord-017897-mbwm0ytg 130 1 Rapid rapid JJ cord-017897-mbwm0ytg 130 2 shallow shallow JJ cord-017897-mbwm0ytg 130 3 breathing breathing NN cord-017897-mbwm0ytg 130 4 index index NN cord-017897-mbwm0ytg 130 5 ( ( -LRB- cord-017897-mbwm0ytg 130 6 RSBI RSBI NNP cord-017897-mbwm0ytg 130 7 ) ) -RRB- cord-017897-mbwm0ytg 130 8 : : : cord-017897-mbwm0ytg 130 9 introduced introduce VBN cord-017897-mbwm0ytg 130 10 by by IN cord-017897-mbwm0ytg 130 11 Tobin Tobin NNP cord-017897-mbwm0ytg 130 12 [ [ -LRB- cord-017897-mbwm0ytg 130 13 76 76 CD cord-017897-mbwm0ytg 130 14 ] ] -RRB- cord-017897-mbwm0ytg 131 1 , , , cord-017897-mbwm0ytg 131 2 it -PRON- PRP cord-017897-mbwm0ytg 131 3 is be VBZ cord-017897-mbwm0ytg 131 4 one one CD cord-017897-mbwm0ytg 131 5 of of IN cord-017897-mbwm0ytg 131 6 the the DT cord-017897-mbwm0ytg 131 7 most most RBS cord-017897-mbwm0ytg 131 8 common common JJ cord-017897-mbwm0ytg 131 9 indexes index NNS cord-017897-mbwm0ytg 131 10 used use VBD cord-017897-mbwm0ytg 131 11 to to TO cord-017897-mbwm0ytg 131 12 evaluate evaluate VB cord-017897-mbwm0ytg 131 13 patients patient NNS cord-017897-mbwm0ytg 131 14 in in IN cord-017897-mbwm0ytg 131 15 weaning weaning NN cord-017897-mbwm0ytg 131 16 process process NN cord-017897-mbwm0ytg 131 17 . . . cord-017897-mbwm0ytg 132 1 It -PRON- PRP cord-017897-mbwm0ytg 132 2 is be VBZ cord-017897-mbwm0ytg 132 3 defined define VBN cord-017897-mbwm0ytg 132 4 as as IN cord-017897-mbwm0ytg 132 5 the the DT cord-017897-mbwm0ytg 132 6 ratio ratio NN cord-017897-mbwm0ytg 132 7 between between IN cord-017897-mbwm0ytg 132 8 the the DT cord-017897-mbwm0ytg 132 9 respiratory respiratory JJ cord-017897-mbwm0ytg 132 10 rate rate NN cord-017897-mbwm0ytg 132 11 and and CC cord-017897-mbwm0ytg 132 12 the the DT cord-017897-mbwm0ytg 132 13 tidal tidal JJ cord-017897-mbwm0ytg 132 14 volume volume NN cord-017897-mbwm0ytg 132 15 expressed express VBN cord-017897-mbwm0ytg 132 16 in in IN cord-017897-mbwm0ytg 132 17 liter liter NN cord-017897-mbwm0ytg 132 18 . . . cord-017897-mbwm0ytg 133 1 Patients patient NNS cord-017897-mbwm0ytg 133 2 that that WDT cord-017897-mbwm0ytg 133 3 tend tend VBP cord-017897-mbwm0ytg 133 4 to to TO cord-017897-mbwm0ytg 133 5 breathe breathe VB cord-017897-mbwm0ytg 133 6 with with IN cord-017897-mbwm0ytg 133 7 a a DT cord-017897-mbwm0ytg 133 8 higher high JJR cord-017897-mbwm0ytg 133 9 respiratory respiratory JJ cord-017897-mbwm0ytg 133 10 rate rate NN cord-017897-mbwm0ytg 133 11 and and CC cord-017897-mbwm0ytg 133 12 with with IN cord-017897-mbwm0ytg 133 13 a a DT cord-017897-mbwm0ytg 133 14 smaller small JJR cord-017897-mbwm0ytg 133 15 tidal tidal JJ cord-017897-mbwm0ytg 133 16 volume volume NN cord-017897-mbwm0ytg 133 17 have have VBP cord-017897-mbwm0ytg 133 18 a a DT cord-017897-mbwm0ytg 133 19 high high JJ cord-017897-mbwm0ytg 133 20 RSBI RSBI NNS cord-017897-mbwm0ytg 133 21 and and CC cord-017897-mbwm0ytg 133 22 more more JJR cord-017897-mbwm0ytg 133 23 probably probably RB cord-017897-mbwm0ytg 133 24 a a DT cord-017897-mbwm0ytg 133 25 higher high JJR cord-017897-mbwm0ytg 133 26 risk risk NN cord-017897-mbwm0ytg 133 27 of of IN cord-017897-mbwm0ytg 133 28 weaning wean VBG cord-017897-mbwm0ytg 133 29 failure failure NN cord-017897-mbwm0ytg 133 30 . . . cord-017897-mbwm0ytg 134 1 The the DT cord-017897-mbwm0ytg 134 2 majority majority NN cord-017897-mbwm0ytg 134 3 part part NN cord-017897-mbwm0ytg 134 4 of of IN cord-017897-mbwm0ytg 134 5 centers center NNS cord-017897-mbwm0ytg 134 6 considers consider VBZ cord-017897-mbwm0ytg 134 7 a a DT cord-017897-mbwm0ytg 134 8 RSBI RSBI NNP cord-017897-mbwm0ytg 134 9 < < XX cord-017897-mbwm0ytg 134 10 105 105 CD cord-017897-mbwm0ytg 134 11 adequate adequate JJ cord-017897-mbwm0ytg 134 12 to to TO cord-017897-mbwm0ytg 134 13 start start VB cord-017897-mbwm0ytg 134 14 weaning wean VBG cord-017897-mbwm0ytg 134 15 the the DT cord-017897-mbwm0ytg 134 16 patient patient NN cord-017897-mbwm0ytg 134 17 from from IN cord-017897-mbwm0ytg 134 18 mechanical mechanical JJ cord-017897-mbwm0ytg 134 19 ventilation ventilation NN cord-017897-mbwm0ytg 134 20 [ [ -LRB- cord-017897-mbwm0ytg 134 21 77 77 CD cord-017897-mbwm0ytg 134 22 ] ] -RRB- cord-017897-mbwm0ytg 134 23 . . . cord-017897-mbwm0ytg 135 1 Mechanical mechanical JJ cord-017897-mbwm0ytg 135 2 ventilation ventilation NN cord-017897-mbwm0ytg 135 3 is be VBZ cord-017897-mbwm0ytg 135 4 a a DT cord-017897-mbwm0ytg 135 5 life life NN cord-017897-mbwm0ytg 135 6 - - HYPH cord-017897-mbwm0ytg 135 7 saving save VBG cord-017897-mbwm0ytg 135 8 intervention intervention NN cord-017897-mbwm0ytg 135 9 in in IN cord-017897-mbwm0ytg 135 10 patients patient NNS cord-017897-mbwm0ytg 135 11 affected affect VBN cord-017897-mbwm0ytg 135 12 by by IN cord-017897-mbwm0ytg 135 13 acute acute JJ cord-017897-mbwm0ytg 135 14 respiratory respiratory JJ cord-017897-mbwm0ytg 135 15 distress distress NN cord-017897-mbwm0ytg 135 16 , , , cord-017897-mbwm0ytg 135 17 but but CC cord-017897-mbwm0ytg 135 18 it -PRON- PRP cord-017897-mbwm0ytg 135 19 is be VBZ cord-017897-mbwm0ytg 135 20 also also RB cord-017897-mbwm0ytg 135 21 associated associate VBN cord-017897-mbwm0ytg 135 22 with with IN cord-017897-mbwm0ytg 135 23 complications complication NNS cord-017897-mbwm0ytg 135 24 . . . cord-017897-mbwm0ytg 136 1 Therefore therefore RB cord-017897-mbwm0ytg 136 2 it -PRON- PRP cord-017897-mbwm0ytg 136 3 is be VBZ cord-017897-mbwm0ytg 136 4 desirable desirable JJ cord-017897-mbwm0ytg 136 5 to to TO cord-017897-mbwm0ytg 136 6 wean wean VB cord-017897-mbwm0ytg 136 7 patients patient NNS cord-017897-mbwm0ytg 136 8 from from IN cord-017897-mbwm0ytg 136 9 mechanical mechanical JJ cord-017897-mbwm0ytg 136 10 ventilation ventilation NN cord-017897-mbwm0ytg 136 11 as as RB cord-017897-mbwm0ytg 136 12 soon soon RB cord-017897-mbwm0ytg 136 13 as as IN cord-017897-mbwm0ytg 136 14 the the DT cord-017897-mbwm0ytg 136 15 underlying underlying JJ cord-017897-mbwm0ytg 136 16 cause cause NN cord-017897-mbwm0ytg 136 17 that that WDT cord-017897-mbwm0ytg 136 18 led lead VBD cord-017897-mbwm0ytg 136 19 to to IN cord-017897-mbwm0ytg 136 20 the the DT cord-017897-mbwm0ytg 136 21 need need NN cord-017897-mbwm0ytg 136 22 for for IN cord-017897-mbwm0ytg 136 23 ventilatory ventilatory JJ cord-017897-mbwm0ytg 136 24 support support NN cord-017897-mbwm0ytg 136 25 is be VBZ cord-017897-mbwm0ytg 136 26 resolved resolve VBN cord-017897-mbwm0ytg 136 27 or or CC cord-017897-mbwm0ytg 136 28 the the DT cord-017897-mbwm0ytg 136 29 patient patient NN cord-017897-mbwm0ytg 136 30 has have VBZ cord-017897-mbwm0ytg 136 31 sufficiently sufficiently RB cord-017897-mbwm0ytg 136 32 improved improve VBN cord-017897-mbwm0ytg 136 33 and and CC cord-017897-mbwm0ytg 136 34 is be VBZ cord-017897-mbwm0ytg 136 35 able able JJ cord-017897-mbwm0ytg 136 36 to to TO cord-017897-mbwm0ytg 136 37 sustain sustain VB cord-017897-mbwm0ytg 136 38 spontaneous spontaneous JJ cord-017897-mbwm0ytg 136 39 breathing breathing NN cord-017897-mbwm0ytg 136 40 with with IN cord-017897-mbwm0ytg 136 41 adequate adequate JJ cord-017897-mbwm0ytg 136 42 respiratory respiratory JJ cord-017897-mbwm0ytg 136 43 mechanics mechanic NNS cord-017897-mbwm0ytg 136 44 and and CC cord-017897-mbwm0ytg 136 45 gas gas NN cord-017897-mbwm0ytg 136 46 exchange exchange NN cord-017897-mbwm0ytg 136 47 . . . cord-017897-mbwm0ytg 137 1 Recently recently RB cord-017897-mbwm0ytg 137 2 , , , cord-017897-mbwm0ytg 137 3 there there EX cord-017897-mbwm0ytg 137 4 were be VBD cord-017897-mbwm0ytg 137 5 published publish VBN cord-017897-mbwm0ytg 137 6 some some DT cord-017897-mbwm0ytg 137 7 guidelines guideline NNS cord-017897-mbwm0ytg 137 8 aimed aim VBN cord-017897-mbwm0ytg 137 9 at at IN cord-017897-mbwm0ytg 137 10 giving give VBG cord-017897-mbwm0ytg 137 11 indications indication NNS cord-017897-mbwm0ytg 137 12 on on IN cord-017897-mbwm0ytg 137 13 which which WDT cord-017897-mbwm0ytg 137 14 weaning weaning NN cord-017897-mbwm0ytg 137 15 / / SYM cord-017897-mbwm0ytg 137 16 extubation extubation NN cord-017897-mbwm0ytg 137 17 techniques technique NNS cord-017897-mbwm0ytg 137 18 it -PRON- PRP cord-017897-mbwm0ytg 137 19 is be VBZ cord-017897-mbwm0ytg 137 20 recommended recommend VBN cord-017897-mbwm0ytg 137 21 to to TO cord-017897-mbwm0ytg 137 22 use use VB cord-017897-mbwm0ytg 137 23 in in IN cord-017897-mbwm0ytg 137 24 patients patient NNS cord-017897-mbwm0ytg 137 25 under under IN cord-017897-mbwm0ytg 137 26 mechanical mechanical JJ cord-017897-mbwm0ytg 137 27 ventilation ventilation NN cord-017897-mbwm0ytg 137 28 [ [ -LRB- cord-017897-mbwm0ytg 137 29 78 78 CD cord-017897-mbwm0ytg 137 30 ] ] -RRB- cord-017897-mbwm0ytg 137 31 : : : cord-017897-mbwm0ytg 138 1 -For -For . cord-017897-mbwm0ytg 139 1 acutely acutely RB cord-017897-mbwm0ytg 139 2 hospitalized hospitalize VBN cord-017897-mbwm0ytg 139 3 patients patient NNS cord-017897-mbwm0ytg 139 4 ventilated ventilate VBD cord-017897-mbwm0ytg 139 5 more more JJR cord-017897-mbwm0ytg 139 6 than than IN cord-017897-mbwm0ytg 139 7 24 24 CD cord-017897-mbwm0ytg 139 8 h h NN cord-017897-mbwm0ytg 139 9 who who WP cord-017897-mbwm0ytg 139 10 are be VBP cord-017897-mbwm0ytg 139 11 able able JJ cord-017897-mbwm0ytg 139 12 to to TO cord-017897-mbwm0ytg 139 13 make make VB cord-017897-mbwm0ytg 139 14 a a DT cord-017897-mbwm0ytg 139 15 weaning weaning NN cord-017897-mbwm0ytg 139 16 attempt attempt NN cord-017897-mbwm0ytg 139 17 , , , cord-017897-mbwm0ytg 139 18 it -PRON- PRP cord-017897-mbwm0ytg 139 19 is be VBZ cord-017897-mbwm0ytg 139 20 recommended recommend VBN cord-017897-mbwm0ytg 139 21 to to TO cord-017897-mbwm0ytg 139 22 carry carry VB cord-017897-mbwm0ytg 139 23 out out RP cord-017897-mbwm0ytg 139 24 an an DT cord-017897-mbwm0ytg 139 25 initial initial JJ cord-017897-mbwm0ytg 139 26 spontaneous spontaneous JJ cord-017897-mbwm0ytg 139 27 breathing breathing NN cord-017897-mbwm0ytg 139 28 trial trial NN cord-017897-mbwm0ytg 139 29 with with IN cord-017897-mbwm0ytg 139 30 inspiratory inspiratory JJ cord-017897-mbwm0ytg 139 31 pressure pressure NN cord-017897-mbwm0ytg 139 32 support support NN cord-017897-mbwm0ytg 139 33 ( ( -LRB- cord-017897-mbwm0ytg 139 34 5 5 CD cord-017897-mbwm0ytg 139 35 - - SYM cord-017897-mbwm0ytg 139 36 8 8 CD cord-017897-mbwm0ytg 139 37 cmH cmh NN cord-017897-mbwm0ytg 139 38 2 2 CD cord-017897-mbwm0ytg 139 39 O o NN cord-017897-mbwm0ytg 139 40 ) ) -RRB- cord-017897-mbwm0ytg 139 41 . . . cord-017897-mbwm0ytg 140 1 -For -For . cord-017897-mbwm0ytg 141 1 acutely acutely RB cord-017897-mbwm0ytg 141 2 hospitalized hospitalize VBN cord-017897-mbwm0ytg 141 3 patients patient NNS cord-017897-mbwm0ytg 141 4 ventilated ventilate VBN cord-017897-mbwm0ytg 141 5 for for IN cord-017897-mbwm0ytg 141 6 more more JJR cord-017897-mbwm0ytg 141 7 than than IN cord-017897-mbwm0ytg 141 8 24 24 CD cord-017897-mbwm0ytg 141 9 h h NN cord-017897-mbwm0ytg 141 10 , , , cord-017897-mbwm0ytg 141 11 it -PRON- PRP cord-017897-mbwm0ytg 141 12 is be VBZ cord-017897-mbwm0ytg 141 13 suggested suggest VBN cord-017897-mbwm0ytg 141 14 to to TO cord-017897-mbwm0ytg 141 15 use use VB cord-017897-mbwm0ytg 141 16 protocols protocol NNS cord-017897-mbwm0ytg 141 17 to to TO cord-017897-mbwm0ytg 141 18 minimize minimize VB cord-017897-mbwm0ytg 141 19 sedation sedation NN cord-017897-mbwm0ytg 141 20 or or CC cord-017897-mbwm0ytg 141 21 guarantee guarantee VB cord-017897-mbwm0ytg 141 22 sedative sedative JJ cord-017897-mbwm0ytg 141 23 suspension suspension NN cord-017897-mbwm0ytg 141 24 periods period NNS cord-017897-mbwm0ytg 141 25 , , , cord-017897-mbwm0ytg 141 26 during during IN cord-017897-mbwm0ytg 141 27 which which WDT cord-017897-mbwm0ytg 141 28 carry carry VBP cord-017897-mbwm0ytg 141 29 out out RP cord-017897-mbwm0ytg 141 30 a a DT cord-017897-mbwm0ytg 141 31 spontaneous spontaneous JJ cord-017897-mbwm0ytg 141 32 breathing breathing NN cord-017897-mbwm0ytg 141 33 trial trial NN cord-017897-mbwm0ytg 141 34 . . . cord-017897-mbwm0ytg 142 1 -For -For . cord-017897-mbwm0ytg 143 1 acutely acutely RB cord-017897-mbwm0ytg 143 2 hospitalized hospitalize VBN cord-017897-mbwm0ytg 143 3 patients patient NNS cord-017897-mbwm0ytg 143 4 ventilated ventilate VBD cord-017897-mbwm0ytg 143 5 more more JJR cord-017897-mbwm0ytg 143 6 than than IN cord-017897-mbwm0ytg 143 7 24 24 CD cord-017897-mbwm0ytg 143 8 h h NN cord-017897-mbwm0ytg 143 9 at at IN cord-017897-mbwm0ytg 143 10 high high JJ cord-017897-mbwm0ytg 143 11 risk risk NN cord-017897-mbwm0ytg 143 12 for for IN cord-017897-mbwm0ytg 143 13 extubation extubation NN cord-017897-mbwm0ytg 143 14 failure failure NN cord-017897-mbwm0ytg 143 15 and and CC cord-017897-mbwm0ytg 143 16 who who WP cord-017897-mbwm0ytg 143 17 have have VBP cord-017897-mbwm0ytg 143 18 passed pass VBN cord-017897-mbwm0ytg 143 19 a a DT cord-017897-mbwm0ytg 143 20 spontaneous spontaneous JJ cord-017897-mbwm0ytg 143 21 breathing breathing NN cord-017897-mbwm0ytg 143 22 trial trial NN cord-017897-mbwm0ytg 143 23 , , , cord-017897-mbwm0ytg 143 24 it -PRON- PRP cord-017897-mbwm0ytg 143 25 is be VBZ cord-017897-mbwm0ytg 143 26 recommended recommend VBN cord-017897-mbwm0ytg 143 27 the the DT cord-017897-mbwm0ytg 143 28 application application NN cord-017897-mbwm0ytg 143 29 of of IN cord-017897-mbwm0ytg 143 30 noninvasive noninvasive JJ cord-017897-mbwm0ytg 143 31 ventilation ventilation NN cord-017897-mbwm0ytg 143 32 ( ( -LRB- cord-017897-mbwm0ytg 143 33 NIV NIV NNP cord-017897-mbwm0ytg 143 34 ) ) -RRB- cord-017897-mbwm0ytg 143 35 following follow VBG cord-017897-mbwm0ytg 143 36 extubation extubation NN cord-017897-mbwm0ytg 143 37 . . . cord-017897-mbwm0ytg 144 1 Still still RB cord-017897-mbwm0ytg 144 2 today today NN cord-017897-mbwm0ytg 144 3 , , , cord-017897-mbwm0ytg 144 4 ARDS ARDS NNP cord-017897-mbwm0ytg 144 5 represents represent VBZ cord-017897-mbwm0ytg 144 6 a a DT cord-017897-mbwm0ytg 144 7 syndrome syndrome NN cord-017897-mbwm0ytg 144 8 with with IN cord-017897-mbwm0ytg 144 9 a a DT cord-017897-mbwm0ytg 144 10 globally globally RB cord-017897-mbwm0ytg 144 11 high high JJ cord-017897-mbwm0ytg 144 12 incidence incidence NN cord-017897-mbwm0ytg 144 13 and and CC cord-017897-mbwm0ytg 144 14 a a DT cord-017897-mbwm0ytg 144 15 high high JJ cord-017897-mbwm0ytg 144 16 mortality mortality NN cord-017897-mbwm0ytg 144 17 rate rate NN cord-017897-mbwm0ytg 144 18 that that WDT cord-017897-mbwm0ytg 144 19 varies vary VBZ cord-017897-mbwm0ytg 144 20 between between IN cord-017897-mbwm0ytg 144 21 40 40 CD cord-017897-mbwm0ytg 144 22 % % NN cord-017897-mbwm0ytg 144 23 and and CC cord-017897-mbwm0ytg 144 24 60 60 CD cord-017897-mbwm0ytg 144 25 % % NN cord-017897-mbwm0ytg 144 26 . . . cord-017897-mbwm0ytg 145 1 The the DT cord-017897-mbwm0ytg 145 2 use use NN cord-017897-mbwm0ytg 145 3 of of IN cord-017897-mbwm0ytg 145 4 a a DT cord-017897-mbwm0ytg 145 5 systematic systematic JJ cord-017897-mbwm0ytg 145 6 diagnostic diagnostic JJ cord-017897-mbwm0ytg 145 7 approach approach NN cord-017897-mbwm0ytg 145 8 can can MD cord-017897-mbwm0ytg 145 9 help help VB cord-017897-mbwm0ytg 145 10 physicians physician NNS cord-017897-mbwm0ytg 145 11 to to TO cord-017897-mbwm0ytg 145 12 rapidly rapidly RB cord-017897-mbwm0ytg 145 13 identify identify VB cord-017897-mbwm0ytg 145 14 the the DT cord-017897-mbwm0ytg 145 15 triggering trigger VBG cord-017897-mbwm0ytg 145 16 cause cause NN cord-017897-mbwm0ytg 145 17 of of IN cord-017897-mbwm0ytg 145 18 the the DT cord-017897-mbwm0ytg 145 19 syndrome syndrome NN cord-017897-mbwm0ytg 145 20 , , , cord-017897-mbwm0ytg 145 21 making make VBG cord-017897-mbwm0ytg 145 22 it -PRON- PRP cord-017897-mbwm0ytg 145 23 possible possible JJ cord-017897-mbwm0ytg 145 24 to to TO cord-017897-mbwm0ytg 145 25 quickly quickly RB cord-017897-mbwm0ytg 145 26 start start VB cord-017897-mbwm0ytg 145 27 with with IN cord-017897-mbwm0ytg 145 28 the the DT cord-017897-mbwm0ytg 145 29 right right JJ cord-017897-mbwm0ytg 145 30 therapy therapy NN cord-017897-mbwm0ytg 145 31 . . . cord-017897-mbwm0ytg 146 1 Chest chest NN cord-017897-mbwm0ytg 146 2 imaging imaging NN cord-017897-mbwm0ytg 146 3 , , , cord-017897-mbwm0ytg 146 4 mainly mainly RB cord-017897-mbwm0ytg 146 5 represented represent VBN cord-017897-mbwm0ytg 146 6 by by IN cord-017897-mbwm0ytg 146 7 CT CT NNP cord-017897-mbwm0ytg 146 8 scan scan NN cord-017897-mbwm0ytg 146 9 , , , cord-017897-mbwm0ytg 146 10 is be VBZ cord-017897-mbwm0ytg 146 11 of of IN cord-017897-mbwm0ytg 146 12 primary primary JJ cord-017897-mbwm0ytg 146 13 relevance relevance NN cord-017897-mbwm0ytg 146 14 both both DT cord-017897-mbwm0ytg 146 15 in in IN cord-017897-mbwm0ytg 146 16 the the DT cord-017897-mbwm0ytg 146 17 diagnostic diagnostic JJ cord-017897-mbwm0ytg 146 18 pathway pathway NN cord-017897-mbwm0ytg 146 19 and and CC cord-017897-mbwm0ytg 146 20 in in IN cord-017897-mbwm0ytg 146 21 the the DT cord-017897-mbwm0ytg 146 22 evaluation evaluation NN cord-017897-mbwm0ytg 146 23 of of IN cord-017897-mbwm0ytg 146 24 lung lung NN cord-017897-mbwm0ytg 146 25 parenchyma parenchyma NN cord-017897-mbwm0ytg 146 26 recruitability recruitability NN cord-017897-mbwm0ytg 146 27 . . . cord-017897-mbwm0ytg 147 1 The the DT cord-017897-mbwm0ytg 147 2 use use NN cord-017897-mbwm0ytg 147 3 of of IN cord-017897-mbwm0ytg 147 4 lung lung NN cord-017897-mbwm0ytg 147 5 ultrasound ultrasound NN cord-017897-mbwm0ytg 147 6 is be VBZ cord-017897-mbwm0ytg 147 7 gaining gain VBG cord-017897-mbwm0ytg 147 8 a a DT cord-017897-mbwm0ytg 147 9 pivotal pivotal JJ cord-017897-mbwm0ytg 147 10 role role NN cord-017897-mbwm0ytg 147 11 in in IN cord-017897-mbwm0ytg 147 12 the the DT cord-017897-mbwm0ytg 147 13 daily daily JJ cord-017897-mbwm0ytg 147 14 bedside bedside NN cord-017897-mbwm0ytg 147 15 evaluation evaluation NN cord-017897-mbwm0ytg 147 16 of of IN cord-017897-mbwm0ytg 147 17 the the DT cord-017897-mbwm0ytg 147 18 patient patient NN cord-017897-mbwm0ytg 147 19 , , , cord-017897-mbwm0ytg 147 20 thanks thank NNS cord-017897-mbwm0ytg 147 21 to to IN cord-017897-mbwm0ytg 147 22 its -PRON- PRP$ cord-017897-mbwm0ytg 147 23 role role NN cord-017897-mbwm0ytg 147 24 in in IN cord-017897-mbwm0ytg 147 25 the the DT cord-017897-mbwm0ytg 147 26 differential differential JJ cord-017897-mbwm0ytg 147 27 diagnosis diagnosis NN cord-017897-mbwm0ytg 147 28 and and CC cord-017897-mbwm0ytg 147 29 to to IN cord-017897-mbwm0ytg 147 30 the the DT cord-017897-mbwm0ytg 147 31 possibility possibility NN cord-017897-mbwm0ytg 147 32 to to TO cord-017897-mbwm0ytg 147 33 evaluate evaluate VB cord-017897-mbwm0ytg 147 34 right right NN cord-017897-mbwm0ytg 147 35 and and CC cord-017897-mbwm0ytg 147 36 left leave VBN cord-017897-mbwm0ytg 147 37 ventricular ventricular JJ cord-017897-mbwm0ytg 147 38 function function NN cord-017897-mbwm0ytg 147 39 . . . cord-017897-mbwm0ytg 148 1 The the DT cord-017897-mbwm0ytg 148 2 supportive supportive JJ cord-017897-mbwm0ytg 148 3 treatment treatment NN cord-017897-mbwm0ytg 148 4 guaranteed guarantee VBN cord-017897-mbwm0ytg 148 5 to to IN cord-017897-mbwm0ytg 148 6 patients patient NNS cord-017897-mbwm0ytg 148 7 with with IN cord-017897-mbwm0ytg 148 8 respiratory respiratory JJ cord-017897-mbwm0ytg 148 9 distress distress NN cord-017897-mbwm0ytg 148 10 needs need VBZ cord-017897-mbwm0ytg 148 11 to to TO cord-017897-mbwm0ytg 148 12 be be VB cord-017897-mbwm0ytg 148 13 oriented orient VBN cord-017897-mbwm0ytg 148 14 to to IN cord-017897-mbwm0ytg 148 15 the the DT cord-017897-mbwm0ytg 148 16 maintenance maintenance NN cord-017897-mbwm0ytg 148 17 of of IN cord-017897-mbwm0ytg 148 18 vital vital JJ cord-017897-mbwm0ytg 148 19 functions function NNS cord-017897-mbwm0ytg 148 20 , , , cord-017897-mbwm0ytg 148 21 to to IN cord-017897-mbwm0ytg 148 22 the the DT cord-017897-mbwm0ytg 148 23 improvement improvement NN cord-017897-mbwm0ytg 148 24 of of IN cord-017897-mbwm0ytg 148 25 gas gas NN cord-017897-mbwm0ytg 148 26 exchange exchange NN cord-017897-mbwm0ytg 148 27 and and CC cord-017897-mbwm0ytg 148 28 to to IN cord-017897-mbwm0ytg 148 29 the the DT cord-017897-mbwm0ytg 148 30 reduction reduction NN cord-017897-mbwm0ytg 148 31 of of IN cord-017897-mbwm0ytg 148 32 lung lung NN cord-017897-mbwm0ytg 148 33 injury injury NN cord-017897-mbwm0ytg 148 34 risk risk NN cord-017897-mbwm0ytg 148 35 . . . cord-017897-mbwm0ytg 149 1 In in IN cord-017897-mbwm0ytg 149 2 order order NN cord-017897-mbwm0ytg 149 3 to to TO cord-017897-mbwm0ytg 149 4 avoid avoid VB cord-017897-mbwm0ytg 149 5 ventilator ventilator NN cord-017897-mbwm0ytg 149 6 - - HYPH cord-017897-mbwm0ytg 149 7 induced induce VBN cord-017897-mbwm0ytg 149 8 lung lung NN cord-017897-mbwm0ytg 149 9 injury injury NN cord-017897-mbwm0ytg 149 10 and and CC cord-017897-mbwm0ytg 149 11 to to TO cord-017897-mbwm0ytg 149 12 set set VB cord-017897-mbwm0ytg 149 13 a a DT cord-017897-mbwm0ytg 149 14 lung lung NN cord-017897-mbwm0ytg 149 15 protective protective JJ cord-017897-mbwm0ytg 149 16 ventilation ventilation NN cord-017897-mbwm0ytg 149 17 , , , cord-017897-mbwm0ytg 149 18 it -PRON- PRP cord-017897-mbwm0ytg 149 19 is be VBZ cord-017897-mbwm0ytg 149 20 useful useful JJ cord-017897-mbwm0ytg 149 21 to to TO cord-017897-mbwm0ytg 149 22 monitor monitor VB cord-017897-mbwm0ytg 149 23 functional functional JJ cord-017897-mbwm0ytg 149 24 residual residual JJ cord-017897-mbwm0ytg 149 25 capacity capacity NN cord-017897-mbwm0ytg 149 26 ( ( -LRB- cord-017897-mbwm0ytg 149 27 FRC FRC NNP cord-017897-mbwm0ytg 149 28 ) ) -RRB- cord-017897-mbwm0ytg 149 29 and and CC cord-017897-mbwm0ytg 149 30 transpulmonary transpulmonary JJ cord-017897-mbwm0ytg 149 31 pressure pressure NN cord-017897-mbwm0ytg 149 32 . . . cord-017897-mbwm0ytg 150 1 In in IN cord-017897-mbwm0ytg 150 2 the the DT cord-017897-mbwm0ytg 150 3 most most RBS cord-017897-mbwm0ytg 150 4 severe severe JJ cord-017897-mbwm0ytg 150 5 cases case NNS cord-017897-mbwm0ytg 150 6 , , , cord-017897-mbwm0ytg 150 7 it -PRON- PRP cord-017897-mbwm0ytg 150 8 can can MD cord-017897-mbwm0ytg 150 9 be be VB cord-017897-mbwm0ytg 150 10 useful useful JJ cord-017897-mbwm0ytg 150 11 to to TO cord-017897-mbwm0ytg 150 12 use use VB cord-017897-mbwm0ytg 150 13 neuromuscular neuromuscular NN cord-017897-mbwm0ytg 150 14 - - HYPH cord-017897-mbwm0ytg 150 15 blocking block VBG cord-017897-mbwm0ytg 150 16 drugs drug NNS cord-017897-mbwm0ytg 150 17 and and CC cord-017897-mbwm0ytg 150 18 prone prone JJ cord-017897-mbwm0ytg 150 19 position position NN cord-017897-mbwm0ytg 150 20 so so IN cord-017897-mbwm0ytg 150 21 as as IN cord-017897-mbwm0ytg 150 22 to to TO cord-017897-mbwm0ytg 150 23 improve improve VB cord-017897-mbwm0ytg 150 24 ventilation ventilation NN cord-017897-mbwm0ytg 150 25 / / SYM cord-017897-mbwm0ytg 150 26 perfusion perfusion NN cord-017897-mbwm0ytg 150 27 ratio ratio NN cord-017897-mbwm0ytg 150 28 . . . cord-017897-mbwm0ytg 151 1 Another another DT cord-017897-mbwm0ytg 151 2 challenge challenge NN cord-017897-mbwm0ytg 151 3 for for IN cord-017897-mbwm0ytg 151 4 physicians physician NNS cord-017897-mbwm0ytg 151 5 seems seem VBZ cord-017897-mbwm0ytg 151 6 to to TO cord-017897-mbwm0ytg 151 7 be be VB cord-017897-mbwm0ytg 151 8 the the DT cord-017897-mbwm0ytg 151 9 weaning weaning NN cord-017897-mbwm0ytg 151 10 from from IN cord-017897-mbwm0ytg 151 11 mechanical mechanical JJ cord-017897-mbwm0ytg 151 12 ventilation ventilation NN cord-017897-mbwm0ytg 151 13 : : : cord-017897-mbwm0ytg 151 14 the the DT cord-017897-mbwm0ytg 151 15 aim aim NN cord-017897-mbwm0ytg 151 16 is be VBZ cord-017897-mbwm0ytg 151 17 to to TO cord-017897-mbwm0ytg 151 18 exclude exclude VB cord-017897-mbwm0ytg 151 19 all all PDT cord-017897-mbwm0ytg 151 20 the the DT cord-017897-mbwm0ytg 151 21 alterations alteration NNS cord-017897-mbwm0ytg 151 22 that that WDT cord-017897-mbwm0ytg 151 23 may may MD cord-017897-mbwm0ytg 151 24 delay delay VB cord-017897-mbwm0ytg 151 25 or or CC cord-017897-mbwm0ytg 151 26 make make VB cord-017897-mbwm0ytg 151 27 fail fail VB cord-017897-mbwm0ytg 151 28 the the DT cord-017897-mbwm0ytg 151 29 respiratory respiratory JJ cord-017897-mbwm0ytg 151 30 weaning weaning NN cord-017897-mbwm0ytg 151 31 . . . cord-017897-mbwm0ytg 152 1 The the DT cord-017897-mbwm0ytg 152 2 latest late JJS cord-017897-mbwm0ytg 152 3 guidelines guideline NNS cord-017897-mbwm0ytg 152 4 written write VBN cord-017897-mbwm0ytg 152 5 by by IN cord-017897-mbwm0ytg 152 6 the the DT cord-017897-mbwm0ytg 152 7 American American NNP cord-017897-mbwm0ytg 152 8 Thoracic Thoracic NNP cord-017897-mbwm0ytg 152 9 Society Society NNP cord-017897-mbwm0ytg 152 10 and and CC cord-017897-mbwm0ytg 152 11 the the DT cord-017897-mbwm0ytg 152 12 American American NNP cord-017897-mbwm0ytg 152 13 College College NNP cord-017897-mbwm0ytg 152 14 of of IN cord-017897-mbwm0ytg 152 15 Chest Chest NNP cord-017897-mbwm0ytg 152 16 Physicians Physicians NNPS cord-017897-mbwm0ytg 152 17 are be VBP cord-017897-mbwm0ytg 152 18 useful useful JJ cord-017897-mbwm0ytg 152 19 to to TO cord-017897-mbwm0ytg 152 20 treat treat VB cord-017897-mbwm0ytg 152 21 the the DT cord-017897-mbwm0ytg 152 22 patient patient NN cord-017897-mbwm0ytg 152 23 in in IN cord-017897-mbwm0ytg 152 24 this this DT cord-017897-mbwm0ytg 152 25 crucial crucial JJ cord-017897-mbwm0ytg 152 26 phase phase NN cord-017897-mbwm0ytg 152 27 . . . cord-017897-mbwm0ytg 153 1 Evolution evolution NN cord-017897-mbwm0ytg 153 2 of of IN cord-017897-mbwm0ytg 153 3 mechanical mechanical JJ cord-017897-mbwm0ytg 153 4 ventilation ventilation NN cord-017897-mbwm0ytg 153 5 in in IN cord-017897-mbwm0ytg 153 6 response response NN cord-017897-mbwm0ytg 153 7 to to IN cord-017897-mbwm0ytg 153 8 clinical clinical JJ cord-017897-mbwm0ytg 153 9 research research NN cord-017897-mbwm0ytg 153 10 Acute acute JJ cord-017897-mbwm0ytg 153 11 respiratory respiratory JJ cord-017897-mbwm0ytg 153 12 distress distress NN cord-017897-mbwm0ytg 153 13 in in IN cord-017897-mbwm0ytg 153 14 adults adult NNS cord-017897-mbwm0ytg 154 1 The the DT cord-017897-mbwm0ytg 154 2 American american JJ cord-017897-mbwm0ytg 154 3 - - HYPH cord-017897-mbwm0ytg 154 4 European European NNP cord-017897-mbwm0ytg 154 5 Consensus Consensus NNP cord-017897-mbwm0ytg 154 6 Conference Conference NNP cord-017897-mbwm0ytg 154 7 on on IN cord-017897-mbwm0ytg 154 8 ARDS ARDS NNP cord-017897-mbwm0ytg 154 9 . . . cord-017897-mbwm0ytg 155 1 Definitions definition NNS cord-017897-mbwm0ytg 155 2 , , , cord-017897-mbwm0ytg 155 3 mechanisms mechanism NNS cord-017897-mbwm0ytg 155 4 , , , cord-017897-mbwm0ytg 155 5 relevant relevant JJ cord-017897-mbwm0ytg 155 6 outcomes outcome NNS cord-017897-mbwm0ytg 155 7 , , , cord-017897-mbwm0ytg 155 8 and and CC cord-017897-mbwm0ytg 155 9 clinical clinical JJ cord-017897-mbwm0ytg 155 10 trial trial NN cord-017897-mbwm0ytg 155 11 coordination coordination NN cord-017897-mbwm0ytg 155 12 Acute acute JJ cord-017897-mbwm0ytg 155 13 respiratory respiratory JJ cord-017897-mbwm0ytg 155 14 distress distress NN cord-017897-mbwm0ytg 155 15 syndrome syndrome NN cord-017897-mbwm0ytg 155 16 : : : cord-017897-mbwm0ytg 155 17 the the DT cord-017897-mbwm0ytg 155 18 Berlin Berlin NNP cord-017897-mbwm0ytg 155 19 Definition Definition NNP cord-017897-mbwm0ytg 155 20 Current current JJ cord-017897-mbwm0ytg 155 21 concepts concept NNS cord-017897-mbwm0ytg 155 22 of of IN cord-017897-mbwm0ytg 155 23 ARDS ARDS NNP cord-017897-mbwm0ytg 155 24 : : : cord-017897-mbwm0ytg 155 25 a a DT cord-017897-mbwm0ytg 155 26 narrative narrative NN cord-017897-mbwm0ytg 155 27 review review NN cord-017897-mbwm0ytg 155 28 Lung lung NN cord-017897-mbwm0ytg 155 29 recruitability recruitability NN cord-017897-mbwm0ytg 155 30 is be VBZ cord-017897-mbwm0ytg 155 31 better well RBR cord-017897-mbwm0ytg 155 32 estimated estimate VBN cord-017897-mbwm0ytg 155 33 according accord VBG cord-017897-mbwm0ytg 155 34 to to IN cord-017897-mbwm0ytg 155 35 the the DT cord-017897-mbwm0ytg 155 36 Berlin Berlin NNP cord-017897-mbwm0ytg 155 37 definition definition NN cord-017897-mbwm0ytg 155 38 of of IN cord-017897-mbwm0ytg 155 39 acute acute JJ cord-017897-mbwm0ytg 155 40 respiratory respiratory JJ cord-017897-mbwm0ytg 155 41 distress distress NN cord-017897-mbwm0ytg 155 42 syndrome syndrome NN cord-017897-mbwm0ytg 155 43 at at IN cord-017897-mbwm0ytg 155 44 standard standard JJ cord-017897-mbwm0ytg 155 45 5 5 CD cord-017897-mbwm0ytg 155 46 cm cm NN cord-017897-mbwm0ytg 155 47 H2O h2o NN cord-017897-mbwm0ytg 155 48 rather rather RB cord-017897-mbwm0ytg 155 49 than than IN cord-017897-mbwm0ytg 155 50 higher high JJR cord-017897-mbwm0ytg 155 51 positive positive JJ cord-017897-mbwm0ytg 155 52 end end NN cord-017897-mbwm0ytg 155 53 - - HYPH cord-017897-mbwm0ytg 155 54 expiratory expiratory NN cord-017897-mbwm0ytg 155 55 pressure pressure NN cord-017897-mbwm0ytg 155 56 : : : cord-017897-mbwm0ytg 156 1 a a DT cord-017897-mbwm0ytg 156 2 retrospective retrospective JJ cord-017897-mbwm0ytg 156 3 cohort cohort NN cord-017897-mbwm0ytg 156 4 study study NN cord-017897-mbwm0ytg 156 5 The the DT cord-017897-mbwm0ytg 156 6 Berlin Berlin NNP cord-017897-mbwm0ytg 156 7 definition definition NN cord-017897-mbwm0ytg 156 8 of of IN cord-017897-mbwm0ytg 156 9 ARDS ARDS NNP cord-017897-mbwm0ytg 156 10 : : : cord-017897-mbwm0ytg 156 11 an an DT cord-017897-mbwm0ytg 156 12 expanded expand VBN cord-017897-mbwm0ytg 156 13 rationale rationale NN cord-017897-mbwm0ytg 156 14 , , , cord-017897-mbwm0ytg 156 15 justification justification NN cord-017897-mbwm0ytg 156 16 , , , cord-017897-mbwm0ytg 156 17 and and CC cord-017897-mbwm0ytg 156 18 supplementary supplementary JJ cord-017897-mbwm0ytg 156 19 material material NN cord-017897-mbwm0ytg 157 1 The the DT cord-017897-mbwm0ytg 157 2 acute acute JJ cord-017897-mbwm0ytg 157 3 respiratory respiratory JJ cord-017897-mbwm0ytg 157 4 distress distress NN cord-017897-mbwm0ytg 157 5 syndrome syndrome NN cord-017897-mbwm0ytg 157 6 Viral viral JJ cord-017897-mbwm0ytg 157 7 community community NN cord-017897-mbwm0ytg 157 8 - - HYPH cord-017897-mbwm0ytg 157 9 acquired acquire VBN cord-017897-mbwm0ytg 157 10 pneumonia pneumonia NN cord-017897-mbwm0ytg 157 11 in in IN cord-017897-mbwm0ytg 157 12 non non JJ cord-017897-mbwm0ytg 157 13 immunocompromised immunocompromised JJ cord-017897-mbwm0ytg 157 14 adults adult NNS cord-017897-mbwm0ytg 157 15 Incidence incidence NN cord-017897-mbwm0ytg 157 16 and and CC cord-017897-mbwm0ytg 157 17 characteristics characteristic NNS cord-017897-mbwm0ytg 157 18 of of IN cord-017897-mbwm0ytg 157 19 viral viral JJ cord-017897-mbwm0ytg 157 20 community community NN cord-017897-mbwm0ytg 157 21 - - HYPH cord-017897-mbwm0ytg 157 22 acquired acquire VBN cord-017897-mbwm0ytg 157 23 pneumonia pneumonia NN cord-017897-mbwm0ytg 157 24 in in IN cord-017897-mbwm0ytg 157 25 adults adult NNS cord-017897-mbwm0ytg 157 26 Virus Virus NNP cord-017897-mbwm0ytg 157 27 - - HYPH cord-017897-mbwm0ytg 157 28 induced induce VBN cord-017897-mbwm0ytg 157 29 acute acute JJ cord-017897-mbwm0ytg 157 30 respiratory respiratory JJ cord-017897-mbwm0ytg 157 31 distress distress NN cord-017897-mbwm0ytg 157 32 syndrome syndrome NN cord-017897-mbwm0ytg 157 33 : : : cord-017897-mbwm0ytg 158 1 epidemiology epidemiology NN cord-017897-mbwm0ytg 158 2 , , , cord-017897-mbwm0ytg 158 3 management management NN cord-017897-mbwm0ytg 158 4 and and CC cord-017897-mbwm0ytg 158 5 outcome outcome NN cord-017897-mbwm0ytg 158 6 Viral viral JJ cord-017897-mbwm0ytg 158 7 infection infection NN cord-017897-mbwm0ytg 158 8 in in IN cord-017897-mbwm0ytg 158 9 patients patient NNS cord-017897-mbwm0ytg 158 10 with with IN cord-017897-mbwm0ytg 158 11 severe severe JJ cord-017897-mbwm0ytg 158 12 pneumonia pneumonia NN cord-017897-mbwm0ytg 158 13 requiring require VBG cord-017897-mbwm0ytg 158 14 intensive intensive JJ cord-017897-mbwm0ytg 158 15 care care NN cord-017897-mbwm0ytg 158 16 unit unit NN cord-017897-mbwm0ytg 158 17 admission admission NN cord-017897-mbwm0ytg 158 18 Clinical clinical JJ cord-017897-mbwm0ytg 158 19 aspects aspect NNS cord-017897-mbwm0ytg 158 20 of of IN cord-017897-mbwm0ytg 158 21 pandemic pandemic NN cord-017897-mbwm0ytg 158 22 2009 2009 CD cord-017897-mbwm0ytg 159 1 influenza influenza NNP cord-017897-mbwm0ytg 159 2 A A NNP cord-017897-mbwm0ytg 159 3 ( ( -LRB- cord-017897-mbwm0ytg 159 4 H1N1 H1N1 NNP cord-017897-mbwm0ytg 159 5 ) ) -RRB- cord-017897-mbwm0ytg 159 6 virus virus NN cord-017897-mbwm0ytg 159 7 infection infection NN cord-017897-mbwm0ytg 159 8 Diagnostic diagnostic JJ cord-017897-mbwm0ytg 159 9 workup workup NN cord-017897-mbwm0ytg 159 10 for for IN cord-017897-mbwm0ytg 159 11 ARDS ARDS NNP cord-017897-mbwm0ytg 159 12 patients patient NNS cord-017897-mbwm0ytg 159 13 Molecular molecular JJ cord-017897-mbwm0ytg 159 14 diagnosis diagnosis NN cord-017897-mbwm0ytg 159 15 of of IN cord-017897-mbwm0ytg 159 16 legionella legionella NN cord-017897-mbwm0ytg 159 17 infections infection NNS cord-017897-mbwm0ytg 159 18 -- -- : cord-017897-mbwm0ytg 159 19 clinical clinical JJ cord-017897-mbwm0ytg 159 20 utility utility NN cord-017897-mbwm0ytg 159 21 of of IN cord-017897-mbwm0ytg 159 22 front front JJ cord-017897-mbwm0ytg 159 23 - - HYPH cord-017897-mbwm0ytg 159 24 line line NN cord-017897-mbwm0ytg 159 25 screening screening NN cord-017897-mbwm0ytg 159 26 as as IN cord-017897-mbwm0ytg 159 27 part part NN cord-017897-mbwm0ytg 159 28 of of IN cord-017897-mbwm0ytg 159 29 a a DT cord-017897-mbwm0ytg 159 30 pneumonia pneumonia NN cord-017897-mbwm0ytg 159 31 diagnostic diagnostic JJ cord-017897-mbwm0ytg 159 32 algorithm algorithm NN cord-017897-mbwm0ytg 159 33 Acute acute JJ cord-017897-mbwm0ytg 159 34 respiratory respiratory JJ cord-017897-mbwm0ytg 159 35 distress distress NN cord-017897-mbwm0ytg 159 36 syndrome syndrome NN cord-017897-mbwm0ytg 159 37 mimickers mimicker NNS cord-017897-mbwm0ytg 159 38 lacking lack VBG cord-017897-mbwm0ytg 159 39 common common JJ cord-017897-mbwm0ytg 159 40 risk risk NN cord-017897-mbwm0ytg 159 41 factors factor NNS cord-017897-mbwm0ytg 159 42 of of IN cord-017897-mbwm0ytg 159 43 the the DT cord-017897-mbwm0ytg 159 44 Berlin Berlin NNP cord-017897-mbwm0ytg 159 45 definition definition NN cord-017897-mbwm0ytg 159 46 Vertical vertical JJ cord-017897-mbwm0ytg 159 47 gradient gradient NN cord-017897-mbwm0ytg 159 48 of of IN cord-017897-mbwm0ytg 159 49 regional regional JJ cord-017897-mbwm0ytg 159 50 lung lung NN cord-017897-mbwm0ytg 159 51 inflation inflation NN cord-017897-mbwm0ytg 159 52 in in IN cord-017897-mbwm0ytg 159 53 adult adult JJ cord-017897-mbwm0ytg 159 54 respiratory respiratory JJ cord-017897-mbwm0ytg 159 55 distress distress NN cord-017897-mbwm0ytg 159 56 syndrome syndrome NN cord-017897-mbwm0ytg 159 57 Adult adult JJ cord-017897-mbwm0ytg 159 58 respiratory respiratory JJ cord-017897-mbwm0ytg 159 59 distress distress NN cord-017897-mbwm0ytg 159 60 syndrome syndrome NN cord-017897-mbwm0ytg 159 61 due due IN cord-017897-mbwm0ytg 159 62 to to IN cord-017897-mbwm0ytg 159 63 pulmonary pulmonary JJ cord-017897-mbwm0ytg 159 64 and and CC cord-017897-mbwm0ytg 159 65 extrapulmonary extrapulmonary JJ cord-017897-mbwm0ytg 159 66 causes cause NNS cord-017897-mbwm0ytg 159 67 : : : cord-017897-mbwm0ytg 159 68 CT CT NNP cord-017897-mbwm0ytg 159 69 , , , cord-017897-mbwm0ytg 159 70 clinical clinical JJ cord-017897-mbwm0ytg 159 71 , , , cord-017897-mbwm0ytg 159 72 and and CC cord-017897-mbwm0ytg 159 73 functional functional JJ cord-017897-mbwm0ytg 159 74 correlations correlation NNS cord-017897-mbwm0ytg 159 75 Ultrasound Ultrasound NNP cord-017897-mbwm0ytg 159 76 in in IN cord-017897-mbwm0ytg 159 77 the the DT cord-017897-mbwm0ytg 159 78 management management NN cord-017897-mbwm0ytg 159 79 of of IN cord-017897-mbwm0ytg 159 80 thoracic thoracic JJ cord-017897-mbwm0ytg 159 81 disease disease NN cord-017897-mbwm0ytg 159 82 International international JJ cord-017897-mbwm0ytg 159 83 evidence evidence NN cord-017897-mbwm0ytg 159 84 - - HYPH cord-017897-mbwm0ytg 159 85 based base VBN cord-017897-mbwm0ytg 159 86 recommendations recommendation NNS cord-017897-mbwm0ytg 159 87 for for IN cord-017897-mbwm0ytg 159 88 point point NN cord-017897-mbwm0ytg 159 89 - - HYPH cord-017897-mbwm0ytg 159 90 of of IN cord-017897-mbwm0ytg 159 91 - - HYPH cord-017897-mbwm0ytg 159 92 care care NN cord-017897-mbwm0ytg 159 93 lung lung NN cord-017897-mbwm0ytg 159 94 ultrasound ultrasound NN cord-017897-mbwm0ytg 159 95 Ultrasound Ultrasound NNP cord-017897-mbwm0ytg 159 96 assessment assessment NN cord-017897-mbwm0ytg 159 97 of of IN cord-017897-mbwm0ytg 159 98 antibiotic antibiotic NN cord-017897-mbwm0ytg 159 99 - - HYPH cord-017897-mbwm0ytg 159 100 induced induce VBN cord-017897-mbwm0ytg 159 101 pulmonary pulmonary JJ cord-017897-mbwm0ytg 159 102 reaeration reaeration NN cord-017897-mbwm0ytg 159 103 in in IN cord-017897-mbwm0ytg 159 104 ventilator ventilator NN cord-017897-mbwm0ytg 159 105 - - HYPH cord-017897-mbwm0ytg 159 106 associated associate VBN cord-017897-mbwm0ytg 159 107 pneumonia pneumonia NN cord-017897-mbwm0ytg 160 1 The the DT cord-017897-mbwm0ytg 160 2 value value NN cord-017897-mbwm0ytg 160 3 of of IN cord-017897-mbwm0ytg 160 4 lung lung NN cord-017897-mbwm0ytg 160 5 ultrasound ultrasound NN cord-017897-mbwm0ytg 160 6 monitoring monitoring NN cord-017897-mbwm0ytg 160 7 in in IN cord-017897-mbwm0ytg 160 8 H1N1 H1N1 NNP cord-017897-mbwm0ytg 160 9 acute acute JJ cord-017897-mbwm0ytg 160 10 respiratory respiratory JJ cord-017897-mbwm0ytg 160 11 distress distress NN cord-017897-mbwm0ytg 160 12 syndrome syndrome NN cord-017897-mbwm0ytg 160 13 Relevance relevance NN cord-017897-mbwm0ytg 160 14 of of IN cord-017897-mbwm0ytg 160 15 lung lung NN cord-017897-mbwm0ytg 160 16 ultrasound ultrasound NN cord-017897-mbwm0ytg 160 17 in in IN cord-017897-mbwm0ytg 160 18 the the DT cord-017897-mbwm0ytg 160 19 diagnosis diagnosis NN cord-017897-mbwm0ytg 160 20 of of IN cord-017897-mbwm0ytg 160 21 acute acute JJ cord-017897-mbwm0ytg 160 22 respiratory respiratory JJ cord-017897-mbwm0ytg 160 23 failure failure NN cord-017897-mbwm0ytg 160 24 : : : cord-017897-mbwm0ytg 160 25 the the DT cord-017897-mbwm0ytg 160 26 BLUE blue JJ cord-017897-mbwm0ytg 160 27 protocol protocol NN cord-017897-mbwm0ytg 160 28 Early early JJ cord-017897-mbwm0ytg 160 29 detection detection NN cord-017897-mbwm0ytg 160 30 of of IN cord-017897-mbwm0ytg 160 31 acute acute JJ cord-017897-mbwm0ytg 160 32 lung lung NN cord-017897-mbwm0ytg 160 33 injury injury NN cord-017897-mbwm0ytg 160 34 uncoupled uncouple VBN cord-017897-mbwm0ytg 160 35 to to IN cord-017897-mbwm0ytg 160 36 hypoxemia hypoxemia NN cord-017897-mbwm0ytg 160 37 in in IN cord-017897-mbwm0ytg 160 38 pigs pig NNS cord-017897-mbwm0ytg 160 39 using use VBG cord-017897-mbwm0ytg 160 40 ultrasound ultrasound NN cord-017897-mbwm0ytg 160 41 lung lung NN cord-017897-mbwm0ytg 160 42 comets comet NNS cord-017897-mbwm0ytg 160 43 Chest chest NN cord-017897-mbwm0ytg 160 44 sonography sonography NN cord-017897-mbwm0ytg 160 45 : : : cord-017897-mbwm0ytg 160 46 a a DT cord-017897-mbwm0ytg 160 47 useful useful JJ cord-017897-mbwm0ytg 160 48 tool tool NN cord-017897-mbwm0ytg 160 49 to to TO cord-017897-mbwm0ytg 160 50 differentiate differentiate VB cord-017897-mbwm0ytg 160 51 acute acute JJ cord-017897-mbwm0ytg 160 52 cardiogenic cardiogenic JJ cord-017897-mbwm0ytg 160 53 pulmonary pulmonary JJ cord-017897-mbwm0ytg 160 54 edema edema NN cord-017897-mbwm0ytg 160 55 from from IN cord-017897-mbwm0ytg 160 56 acute acute JJ cord-017897-mbwm0ytg 160 57 respiratory respiratory JJ cord-017897-mbwm0ytg 160 58 distress distress NN cord-017897-mbwm0ytg 160 59 syndrome syndrome NN cord-017897-mbwm0ytg 160 60 Role role NN cord-017897-mbwm0ytg 160 61 of of IN cord-017897-mbwm0ytg 160 62 noninvasive noninvasive JJ cord-017897-mbwm0ytg 160 63 ventilation ventilation NN cord-017897-mbwm0ytg 160 64 in in IN cord-017897-mbwm0ytg 160 65 acute acute JJ cord-017897-mbwm0ytg 160 66 lung lung NN cord-017897-mbwm0ytg 160 67 injury injury NN cord-017897-mbwm0ytg 160 68 / / SYM cord-017897-mbwm0ytg 160 69 acute acute JJ cord-017897-mbwm0ytg 160 70 respiratory respiratory JJ cord-017897-mbwm0ytg 160 71 distress distress NN cord-017897-mbwm0ytg 160 72 syndrome syndrome NN cord-017897-mbwm0ytg 160 73 : : : cord-017897-mbwm0ytg 160 74 a a DT cord-017897-mbwm0ytg 160 75 proportion proportion NN cord-017897-mbwm0ytg 160 76 meta meta NN cord-017897-mbwm0ytg 160 77 - - HYPH cord-017897-mbwm0ytg 160 78 analysis analysis NN cord-017897-mbwm0ytg 160 79 Predictors predictor NNS cord-017897-mbwm0ytg 160 80 of of IN cord-017897-mbwm0ytg 160 81 failure failure NN cord-017897-mbwm0ytg 160 82 of of IN cord-017897-mbwm0ytg 160 83 noninvasive noninvasive JJ cord-017897-mbwm0ytg 160 84 positive positive JJ cord-017897-mbwm0ytg 160 85 pressure pressure NN cord-017897-mbwm0ytg 160 86 ventilation ventilation NN cord-017897-mbwm0ytg 160 87 in in IN cord-017897-mbwm0ytg 160 88 patients patient NNS cord-017897-mbwm0ytg 160 89 with with IN cord-017897-mbwm0ytg 160 90 acute acute JJ cord-017897-mbwm0ytg 160 91 hypoxemic hypoxemic JJ cord-017897-mbwm0ytg 160 92 respiratory respiratory JJ cord-017897-mbwm0ytg 160 93 failure failure NN cord-017897-mbwm0ytg 160 94 : : : cord-017897-mbwm0ytg 160 95 a a DT cord-017897-mbwm0ytg 160 96 multi multi JJ cord-017897-mbwm0ytg 160 97 - - JJ cord-017897-mbwm0ytg 160 98 center center JJ cord-017897-mbwm0ytg 160 99 study study NN cord-017897-mbwm0ytg 160 100 Use Use NNP cord-017897-mbwm0ytg 160 101 of of IN cord-017897-mbwm0ytg 160 102 high high JJ cord-017897-mbwm0ytg 160 103 - - HYPH cord-017897-mbwm0ytg 160 104 flow flow NN cord-017897-mbwm0ytg 160 105 nasal nasal NN cord-017897-mbwm0ytg 160 106 cannula cannula NN cord-017897-mbwm0ytg 160 107 oxygen oxygen NN cord-017897-mbwm0ytg 160 108 therapy therapy NN cord-017897-mbwm0ytg 160 109 in in IN cord-017897-mbwm0ytg 160 110 subjects subject NNS cord-017897-mbwm0ytg 160 111 with with IN cord-017897-mbwm0ytg 160 112 ARDS ARDS NNP cord-017897-mbwm0ytg 160 113 : : : cord-017897-mbwm0ytg 160 114 a a DT cord-017897-mbwm0ytg 160 115 1-year 1-year CD cord-017897-mbwm0ytg 160 116 observational observational JJ cord-017897-mbwm0ytg 160 117 study study NN cord-017897-mbwm0ytg 160 118 Ultra ultra JJ cord-017897-mbwm0ytg 160 119 - - JJ cord-017897-mbwm0ytg 160 120 protective protective JJ cord-017897-mbwm0ytg 160 121 ventilation ventilation NN cord-017897-mbwm0ytg 160 122 and and CC cord-017897-mbwm0ytg 160 123 hypoxemia hypoxemia NN cord-017897-mbwm0ytg 160 124 Recruitment recruitment NN cord-017897-mbwm0ytg 160 125 and and CC cord-017897-mbwm0ytg 160 126 derecruitment derecruitment NN cord-017897-mbwm0ytg 160 127 during during IN cord-017897-mbwm0ytg 160 128 acute acute JJ cord-017897-mbwm0ytg 160 129 respiratory respiratory JJ cord-017897-mbwm0ytg 160 130 failure failure NN cord-017897-mbwm0ytg 160 131 : : : cord-017897-mbwm0ytg 160 132 an an DT cord-017897-mbwm0ytg 160 133 experimental experimental JJ cord-017897-mbwm0ytg 160 134 study study NN cord-017897-mbwm0ytg 160 135 Experimental experimental JJ cord-017897-mbwm0ytg 160 136 pulmonary pulmonary JJ cord-017897-mbwm0ytg 160 137 edema edema NN cord-017897-mbwm0ytg 160 138 due due IN cord-017897-mbwm0ytg 160 139 to to IN cord-017897-mbwm0ytg 160 140 intermittent intermittent JJ cord-017897-mbwm0ytg 160 141 positive positive JJ cord-017897-mbwm0ytg 160 142 pressure pressure NN cord-017897-mbwm0ytg 160 143 ventilation ventilation NN cord-017897-mbwm0ytg 160 144 with with IN cord-017897-mbwm0ytg 160 145 high high JJ cord-017897-mbwm0ytg 160 146 inflation inflation NN cord-017897-mbwm0ytg 160 147 pressures pressure NNS cord-017897-mbwm0ytg 160 148 . . . cord-017897-mbwm0ytg 161 1 Protection protection NN cord-017897-mbwm0ytg 161 2 by by IN cord-017897-mbwm0ytg 161 3 positive positive JJ cord-017897-mbwm0ytg 161 4 end end NN cord-017897-mbwm0ytg 161 5 - - HYPH cord-017897-mbwm0ytg 161 6 expiratory expiratory NN cord-017897-mbwm0ytg 161 7 pressure pressure NN cord-017897-mbwm0ytg 161 8 Multiple multiple JJ cord-017897-mbwm0ytg 161 9 system system NN cord-017897-mbwm0ytg 161 10 organ organ NN cord-017897-mbwm0ytg 161 11 failure failure NN cord-017897-mbwm0ytg 161 12 . . . cord-017897-mbwm0ytg 162 1 Is be VBZ cord-017897-mbwm0ytg 162 2 mechanical mechanical JJ cord-017897-mbwm0ytg 162 3 ventilation ventilation NN cord-017897-mbwm0ytg 162 4 a a DT cord-017897-mbwm0ytg 162 5 contributing contribute VBG cord-017897-mbwm0ytg 162 6 factor factor NN cord-017897-mbwm0ytg 162 7 ? ? . cord-017897-mbwm0ytg 163 1 Lung lung NN cord-017897-mbwm0ytg 163 2 opening opening NN cord-017897-mbwm0ytg 163 3 and and CC cord-017897-mbwm0ytg 163 4 closing close VBG cord-017897-mbwm0ytg 163 5 during during IN cord-017897-mbwm0ytg 163 6 ventilation ventilation NN cord-017897-mbwm0ytg 163 7 of of IN cord-017897-mbwm0ytg 164 1 acute acute JJ cord-017897-mbwm0ytg 164 2 respiratory respiratory JJ cord-017897-mbwm0ytg 164 3 distress distress NN cord-017897-mbwm0ytg 164 4 syndrome syndrome NN cord-017897-mbwm0ytg 164 5 Higher higher RBR cord-017897-mbwm0ytg 164 6 versus versus IN cord-017897-mbwm0ytg 164 7 lower low JJR cord-017897-mbwm0ytg 164 8 positive positive JJ cord-017897-mbwm0ytg 164 9 end end NN cord-017897-mbwm0ytg 164 10 - - HYPH cord-017897-mbwm0ytg 164 11 expiratory expiratory JJ cord-017897-mbwm0ytg 164 12 pressures pressure NNS cord-017897-mbwm0ytg 164 13 in in IN cord-017897-mbwm0ytg 164 14 patients patient NNS cord-017897-mbwm0ytg 164 15 with with IN cord-017897-mbwm0ytg 164 16 the the DT cord-017897-mbwm0ytg 164 17 acute acute JJ cord-017897-mbwm0ytg 164 18 respiratory respiratory JJ cord-017897-mbwm0ytg 164 19 distress distress NN cord-017897-mbwm0ytg 164 20 syndrome syndrome NN cord-017897-mbwm0ytg 164 21 Ventilation ventilation NN cord-017897-mbwm0ytg 164 22 strategy strategy NN cord-017897-mbwm0ytg 164 23 using use VBG cord-017897-mbwm0ytg 164 24 low low JJ cord-017897-mbwm0ytg 164 25 tidal tidal JJ cord-017897-mbwm0ytg 164 26 volumes volume NNS cord-017897-mbwm0ytg 164 27 , , , cord-017897-mbwm0ytg 164 28 recruitment recruitment NN cord-017897-mbwm0ytg 164 29 maneuvers maneuver NNS cord-017897-mbwm0ytg 164 30 , , , cord-017897-mbwm0ytg 164 31 and and CC cord-017897-mbwm0ytg 164 32 high high JJ cord-017897-mbwm0ytg 164 33 positive positive JJ cord-017897-mbwm0ytg 164 34 end end NN cord-017897-mbwm0ytg 164 35 - - HYPH cord-017897-mbwm0ytg 164 36 expiratory expiratory NN cord-017897-mbwm0ytg 164 37 pressure pressure NN cord-017897-mbwm0ytg 164 38 for for IN cord-017897-mbwm0ytg 164 39 acute acute JJ cord-017897-mbwm0ytg 164 40 lung lung NN cord-017897-mbwm0ytg 164 41 injury injury NN cord-017897-mbwm0ytg 164 42 and and CC cord-017897-mbwm0ytg 164 43 acute acute JJ cord-017897-mbwm0ytg 164 44 respiratory respiratory JJ cord-017897-mbwm0ytg 164 45 distress distress NN cord-017897-mbwm0ytg 164 46 syndrome syndrome NN cord-017897-mbwm0ytg 164 47 : : : cord-017897-mbwm0ytg 164 48 a a DT cord-017897-mbwm0ytg 164 49 randomized randomized JJ cord-017897-mbwm0ytg 164 50 controlled control VBN cord-017897-mbwm0ytg 164 51 trial trial NN cord-017897-mbwm0ytg 164 52 Lung Lung NNP cord-017897-mbwm0ytg 164 53 recruitment recruitment NN cord-017897-mbwm0ytg 164 54 assessed assess VBN cord-017897-mbwm0ytg 164 55 by by IN cord-017897-mbwm0ytg 164 56 respiratory respiratory JJ cord-017897-mbwm0ytg 164 57 mechanics mechanic NNS cord-017897-mbwm0ytg 164 58 and and CC cord-017897-mbwm0ytg 164 59 computed compute VBD cord-017897-mbwm0ytg 164 60 tomography tomography NN cord-017897-mbwm0ytg 164 61 in in IN cord-017897-mbwm0ytg 164 62 patients patient NNS cord-017897-mbwm0ytg 164 63 with with IN cord-017897-mbwm0ytg 164 64 acute acute JJ cord-017897-mbwm0ytg 164 65 respiratory respiratory JJ cord-017897-mbwm0ytg 164 66 distress distress NN cord-017897-mbwm0ytg 164 67 syndrome syndrome NN cord-017897-mbwm0ytg 164 68 . . . cord-017897-mbwm0ytg 165 1 what what WP cord-017897-mbwm0ytg 165 2 is be VBZ cord-017897-mbwm0ytg 165 3 the the DT cord-017897-mbwm0ytg 165 4 relationship relationship NN cord-017897-mbwm0ytg 165 5 ? ? . cord-017897-mbwm0ytg 166 1 Compressive compressive JJ cord-017897-mbwm0ytg 166 2 forces force NNS cord-017897-mbwm0ytg 166 3 and and CC cord-017897-mbwm0ytg 166 4 computed compute VBD cord-017897-mbwm0ytg 166 5 tomography tomography NN cord-017897-mbwm0ytg 166 6 - - HYPH cord-017897-mbwm0ytg 166 7 derived derive VBN cord-017897-mbwm0ytg 166 8 positive positive JJ cord-017897-mbwm0ytg 166 9 end end NN cord-017897-mbwm0ytg 166 10 - - HYPH cord-017897-mbwm0ytg 166 11 expiratory expiratory NN cord-017897-mbwm0ytg 166 12 pressure pressure NN cord-017897-mbwm0ytg 166 13 in in IN cord-017897-mbwm0ytg 166 14 acute acute JJ cord-017897-mbwm0ytg 166 15 respiratory respiratory JJ cord-017897-mbwm0ytg 166 16 distress distress NN cord-017897-mbwm0ytg 166 17 syndrome syndrome NN cord-017897-mbwm0ytg 166 18 Recruitment recruitment NN cord-017897-mbwm0ytg 166 19 maneuvers maneuver NNS cord-017897-mbwm0ytg 166 20 in in IN cord-017897-mbwm0ytg 166 21 acute acute JJ cord-017897-mbwm0ytg 166 22 respiratory respiratory JJ cord-017897-mbwm0ytg 166 23 distress distress NN cord-017897-mbwm0ytg 166 24 syndrome syndrome NN cord-017897-mbwm0ytg 166 25 and and CC cord-017897-mbwm0ytg 166 26 during during IN cord-017897-mbwm0ytg 166 27 general general JJ cord-017897-mbwm0ytg 166 28 anesthesia anesthesia NN cord-017897-mbwm0ytg 166 29 Effects effect NNS cord-017897-mbwm0ytg 166 30 of of IN cord-017897-mbwm0ytg 166 31 alveolar alveolar NN cord-017897-mbwm0ytg 166 32 recruitment recruitment NN cord-017897-mbwm0ytg 166 33 maneuvers maneuver NNS cord-017897-mbwm0ytg 166 34 on on IN cord-017897-mbwm0ytg 166 35 clinical clinical JJ cord-017897-mbwm0ytg 166 36 outcomes outcome NNS cord-017897-mbwm0ytg 166 37 in in IN cord-017897-mbwm0ytg 166 38 patients patient NNS cord-017897-mbwm0ytg 166 39 with with IN cord-017897-mbwm0ytg 166 40 acute acute JJ cord-017897-mbwm0ytg 166 41 respiratory respiratory JJ cord-017897-mbwm0ytg 166 42 distress distress NN cord-017897-mbwm0ytg 166 43 syndrome syndrome NN cord-017897-mbwm0ytg 166 44 : : : cord-017897-mbwm0ytg 166 45 a a DT cord-017897-mbwm0ytg 166 46 systematic systematic JJ cord-017897-mbwm0ytg 166 47 review review NN cord-017897-mbwm0ytg 166 48 and and CC cord-017897-mbwm0ytg 166 49 meta meta NNP cord-017897-mbwm0ytg 166 50 - - HYPH cord-017897-mbwm0ytg 166 51 analysis analysis NN cord-017897-mbwm0ytg 166 52 Bedside Bedside NNP cord-017897-mbwm0ytg 166 53 ultrasound ultrasound NN cord-017897-mbwm0ytg 166 54 assessment assessment NN cord-017897-mbwm0ytg 166 55 of of IN cord-017897-mbwm0ytg 166 56 positive positive JJ cord-017897-mbwm0ytg 166 57 end end NN cord-017897-mbwm0ytg 166 58 - - HYPH cord-017897-mbwm0ytg 166 59 expiratory expiratory NN cord-017897-mbwm0ytg 166 60 pressure pressure NN cord-017897-mbwm0ytg 166 61 - - HYPH cord-017897-mbwm0ytg 166 62 induced induce VBN cord-017897-mbwm0ytg 166 63 lung lung NN cord-017897-mbwm0ytg 166 64 recruitment recruitment NN cord-017897-mbwm0ytg 166 65 Lung Lung NNP cord-017897-mbwm0ytg 166 66 stress stress NN cord-017897-mbwm0ytg 166 67 and and CC cord-017897-mbwm0ytg 166 68 strain strain NN cord-017897-mbwm0ytg 166 69 during during IN cord-017897-mbwm0ytg 166 70 mechanical mechanical JJ cord-017897-mbwm0ytg 166 71 ventilation ventilation NN cord-017897-mbwm0ytg 166 72 : : : cord-017897-mbwm0ytg 166 73 any any DT cord-017897-mbwm0ytg 166 74 safe safe JJ cord-017897-mbwm0ytg 166 75 threshold threshold NN cord-017897-mbwm0ytg 166 76 ? ? . cord-017897-mbwm0ytg 167 1 Low low JJ cord-017897-mbwm0ytg 167 2 - - HYPH cord-017897-mbwm0ytg 167 3 dose dose NN cord-017897-mbwm0ytg 167 4 chest chest NN cord-017897-mbwm0ytg 167 5 computed compute VBN cord-017897-mbwm0ytg 167 6 tomography tomography NN cord-017897-mbwm0ytg 167 7 for for IN cord-017897-mbwm0ytg 167 8 quantitative quantitative JJ cord-017897-mbwm0ytg 167 9 and and CC cord-017897-mbwm0ytg 167 10 visual visual JJ cord-017897-mbwm0ytg 167 11 anatomical anatomical JJ cord-017897-mbwm0ytg 167 12 analysis analysis NN cord-017897-mbwm0ytg 167 13 in in IN cord-017897-mbwm0ytg 167 14 patients patient NNS cord-017897-mbwm0ytg 167 15 with with IN cord-017897-mbwm0ytg 167 16 acute acute JJ cord-017897-mbwm0ytg 167 17 respiratory respiratory JJ cord-017897-mbwm0ytg 167 18 distress distress NN cord-017897-mbwm0ytg 167 19 syndrome syndrome NN cord-017897-mbwm0ytg 167 20 Stress stress NN cord-017897-mbwm0ytg 167 21 and and CC cord-017897-mbwm0ytg 167 22 strain strain VB cord-017897-mbwm0ytg 167 23 within within IN cord-017897-mbwm0ytg 167 24 the the DT cord-017897-mbwm0ytg 167 25 lung lung NN cord-017897-mbwm0ytg 168 1 The the DT cord-017897-mbwm0ytg 168 2 assessment assessment NN cord-017897-mbwm0ytg 168 3 of of IN cord-017897-mbwm0ytg 168 4 transpulmonary transpulmonary JJ cord-017897-mbwm0ytg 168 5 pressure pressure NN cord-017897-mbwm0ytg 168 6 in in IN cord-017897-mbwm0ytg 168 7 mechanically mechanically RB cord-017897-mbwm0ytg 168 8 ventilated ventilate VBN cord-017897-mbwm0ytg 168 9 ARDS ARDS NNP cord-017897-mbwm0ytg 168 10 patients patient NNS cord-017897-mbwm0ytg 168 11 Lung Lung NNP cord-017897-mbwm0ytg 168 12 protective protective JJ cord-017897-mbwm0ytg 168 13 ventilation ventilation NN cord-017897-mbwm0ytg 168 14 strategy strategy NN cord-017897-mbwm0ytg 168 15 for for IN cord-017897-mbwm0ytg 168 16 the the DT cord-017897-mbwm0ytg 168 17 acute acute JJ cord-017897-mbwm0ytg 168 18 respiratory respiratory JJ cord-017897-mbwm0ytg 168 19 distress distress NN cord-017897-mbwm0ytg 168 20 syndrome syndrome NN cord-017897-mbwm0ytg 168 21 Lung Lung NNP cord-017897-mbwm0ytg 168 22 stress stress NN cord-017897-mbwm0ytg 168 23 and and CC cord-017897-mbwm0ytg 168 24 strain strain NN cord-017897-mbwm0ytg 168 25 during during IN cord-017897-mbwm0ytg 168 26 mechanical mechanical JJ cord-017897-mbwm0ytg 168 27 ventilation ventilation NN cord-017897-mbwm0ytg 168 28 for for IN cord-017897-mbwm0ytg 168 29 acute acute JJ cord-017897-mbwm0ytg 168 30 respiratory respiratory JJ cord-017897-mbwm0ytg 168 31 distress distress NN cord-017897-mbwm0ytg 168 32 syndrome syndrome NN cord-017897-mbwm0ytg 168 33 Driving drive VBG cord-017897-mbwm0ytg 168 34 pressure pressure NN cord-017897-mbwm0ytg 168 35 and and CC cord-017897-mbwm0ytg 168 36 survival survival NN cord-017897-mbwm0ytg 168 37 in in IN cord-017897-mbwm0ytg 168 38 the the DT cord-017897-mbwm0ytg 168 39 acute acute JJ cord-017897-mbwm0ytg 168 40 respiratory respiratory JJ cord-017897-mbwm0ytg 168 41 distress distress NN cord-017897-mbwm0ytg 168 42 syndrome syndrome NN cord-017897-mbwm0ytg 168 43 Balancing balance VBG cord-017897-mbwm0ytg 168 44 neuromuscular neuromuscular JJ cord-017897-mbwm0ytg 168 45 blockade blockade NN cord-017897-mbwm0ytg 168 46 versus versus IN cord-017897-mbwm0ytg 168 47 preserved preserve VBN cord-017897-mbwm0ytg 168 48 muscle muscle NN cord-017897-mbwm0ytg 168 49 activity activity NN cord-017897-mbwm0ytg 168 50 Low low JJ cord-017897-mbwm0ytg 168 51 mortality mortality NN cord-017897-mbwm0ytg 168 52 rate rate NN cord-017897-mbwm0ytg 168 53 in in IN cord-017897-mbwm0ytg 168 54 adult adult JJ cord-017897-mbwm0ytg 168 55 respiratory respiratory JJ cord-017897-mbwm0ytg 168 56 distress distress NN cord-017897-mbwm0ytg 168 57 syndrome syndrome NN cord-017897-mbwm0ytg 168 58 using use VBG cord-017897-mbwm0ytg 168 59 low low JJ cord-017897-mbwm0ytg 168 60 - - HYPH cord-017897-mbwm0ytg 168 61 volume volume NN cord-017897-mbwm0ytg 168 62 , , , cord-017897-mbwm0ytg 168 63 pressure pressure NN cord-017897-mbwm0ytg 168 64 - - HYPH cord-017897-mbwm0ytg 168 65 limited limit VBN cord-017897-mbwm0ytg 168 66 ventilation ventilation NN cord-017897-mbwm0ytg 168 67 with with IN cord-017897-mbwm0ytg 168 68 permissive permissive JJ cord-017897-mbwm0ytg 168 69 hypercapnia hypercapnia NN cord-017897-mbwm0ytg 168 70 : : : cord-017897-mbwm0ytg 168 71 a a DT cord-017897-mbwm0ytg 168 72 prospective prospective JJ cord-017897-mbwm0ytg 168 73 study study NN cord-017897-mbwm0ytg 168 74 Driving drive VBG cord-017897-mbwm0ytg 168 75 pressure pressure NN cord-017897-mbwm0ytg 168 76 and and CC cord-017897-mbwm0ytg 168 77 intraoperative intraoperative JJ cord-017897-mbwm0ytg 168 78 protective protective JJ cord-017897-mbwm0ytg 168 79 ventilation ventilation NN cord-017897-mbwm0ytg 169 1 Neuromuscular neuromuscular JJ cord-017897-mbwm0ytg 169 2 blocking block VBG cord-017897-mbwm0ytg 169 3 agents agent NNS cord-017897-mbwm0ytg 169 4 in in IN cord-017897-mbwm0ytg 169 5 patients patient NNS cord-017897-mbwm0ytg 169 6 with with IN cord-017897-mbwm0ytg 169 7 acute acute JJ cord-017897-mbwm0ytg 169 8 respiratory respiratory JJ cord-017897-mbwm0ytg 169 9 distress distress NN cord-017897-mbwm0ytg 169 10 syndrome syndrome NN cord-017897-mbwm0ytg 169 11 : : : cord-017897-mbwm0ytg 170 1 a a DT cord-017897-mbwm0ytg 170 2 summary summary NN cord-017897-mbwm0ytg 170 3 of of IN cord-017897-mbwm0ytg 170 4 the the DT cord-017897-mbwm0ytg 170 5 current current JJ cord-017897-mbwm0ytg 170 6 evidence evidence NN cord-017897-mbwm0ytg 170 7 from from IN cord-017897-mbwm0ytg 170 8 three three CD cord-017897-mbwm0ytg 170 9 randomized randomized JJ cord-017897-mbwm0ytg 170 10 controlled control VBN cord-017897-mbwm0ytg 170 11 trials trial NNS cord-017897-mbwm0ytg 170 12 The the DT cord-017897-mbwm0ytg 170 13 prone prone JJ cord-017897-mbwm0ytg 170 14 position position NN cord-017897-mbwm0ytg 170 15 in in IN cord-017897-mbwm0ytg 170 16 ARDS ARDS NNP cord-017897-mbwm0ytg 170 17 patients patient NNS cord-017897-mbwm0ytg 170 18 Use Use NNP cord-017897-mbwm0ytg 170 19 of of IN cord-017897-mbwm0ytg 170 20 extreme extreme JJ cord-017897-mbwm0ytg 170 21 position position NN cord-017897-mbwm0ytg 170 22 changes change NNS cord-017897-mbwm0ytg 170 23 in in IN cord-017897-mbwm0ytg 170 24 acute acute JJ cord-017897-mbwm0ytg 170 25 respiratory respiratory JJ cord-017897-mbwm0ytg 170 26 failure failure NN cord-017897-mbwm0ytg 170 27 Prone prone JJ cord-017897-mbwm0ytg 170 28 position position NN cord-017897-mbwm0ytg 170 29 in in IN cord-017897-mbwm0ytg 170 30 acute acute JJ cord-017897-mbwm0ytg 170 31 respiratory respiratory JJ cord-017897-mbwm0ytg 170 32 distress distress NN cord-017897-mbwm0ytg 170 33 syndrome syndrome NN cord-017897-mbwm0ytg 170 34 . . . cord-017897-mbwm0ytg 171 1 Rationale rationale NN cord-017897-mbwm0ytg 171 2 , , , cord-017897-mbwm0ytg 171 3 indications indication NNS cord-017897-mbwm0ytg 171 4 , , , cord-017897-mbwm0ytg 171 5 and and CC cord-017897-mbwm0ytg 171 6 limits limit VBZ cord-017897-mbwm0ytg 171 7 Prone prone JJ cord-017897-mbwm0ytg 171 8 positioning positioning NN cord-017897-mbwm0ytg 171 9 and and CC cord-017897-mbwm0ytg 171 10 neuromuscular neuromuscular NN cord-017897-mbwm0ytg 171 11 blocking block VBG cord-017897-mbwm0ytg 171 12 agents agent NNS cord-017897-mbwm0ytg 171 13 are be VBP cord-017897-mbwm0ytg 171 14 part part NN cord-017897-mbwm0ytg 171 15 of of IN cord-017897-mbwm0ytg 171 16 standard standard JJ cord-017897-mbwm0ytg 171 17 care care NN cord-017897-mbwm0ytg 171 18 in in IN cord-017897-mbwm0ytg 171 19 severe severe JJ cord-017897-mbwm0ytg 171 20 ARDS ARDS NNP cord-017897-mbwm0ytg 171 21 patients patient NNS cord-017897-mbwm0ytg 171 22 : : : cord-017897-mbwm0ytg 172 1 yes yes UH cord-017897-mbwm0ytg 172 2 Effect effect NN cord-017897-mbwm0ytg 172 3 of of IN cord-017897-mbwm0ytg 172 4 prolonged prolong VBN cord-017897-mbwm0ytg 172 5 methylprednisolone methylprednisolone NN cord-017897-mbwm0ytg 172 6 therapy therapy NN cord-017897-mbwm0ytg 172 7 in in IN cord-017897-mbwm0ytg 172 8 unresolving unresolve VBG cord-017897-mbwm0ytg 172 9 acute acute JJ cord-017897-mbwm0ytg 172 10 respiratory respiratory JJ cord-017897-mbwm0ytg 172 11 distress distress NN cord-017897-mbwm0ytg 172 12 syndrome syndrome NN cord-017897-mbwm0ytg 172 13 : : : cord-017897-mbwm0ytg 172 14 a a DT cord-017897-mbwm0ytg 172 15 randomized randomized JJ cord-017897-mbwm0ytg 172 16 controlled control VBN cord-017897-mbwm0ytg 172 17 trial trial NN cord-017897-mbwm0ytg 172 18 Efficacy Efficacy NNP cord-017897-mbwm0ytg 172 19 and and CC cord-017897-mbwm0ytg 172 20 safety safety NN cord-017897-mbwm0ytg 172 21 of of IN cord-017897-mbwm0ytg 172 22 corticosteroids corticosteroid NNS cord-017897-mbwm0ytg 172 23 for for IN cord-017897-mbwm0ytg 172 24 persistent persistent JJ cord-017897-mbwm0ytg 172 25 acute acute JJ cord-017897-mbwm0ytg 172 26 respiratory respiratory JJ cord-017897-mbwm0ytg 172 27 distress distress NN cord-017897-mbwm0ytg 172 28 syndrome syndrome NN cord-017897-mbwm0ytg 172 29 High high JJ cord-017897-mbwm0ytg 172 30 - - HYPH cord-017897-mbwm0ytg 172 31 dose dose NN cord-017897-mbwm0ytg 172 32 corticosteroids corticosteroid NNS cord-017897-mbwm0ytg 172 33 in in IN cord-017897-mbwm0ytg 172 34 patients patient NNS cord-017897-mbwm0ytg 172 35 with with IN cord-017897-mbwm0ytg 172 36 the the DT cord-017897-mbwm0ytg 172 37 adult adult NN cord-017897-mbwm0ytg 172 38 respiratory respiratory JJ cord-017897-mbwm0ytg 172 39 distress distress NN cord-017897-mbwm0ytg 172 40 syndrome syndrome NN cord-017897-mbwm0ytg 172 41 Pulmonary pulmonary JJ cord-017897-mbwm0ytg 172 42 vasodilators vasodilator NNS cord-017897-mbwm0ytg 172 43 . . . cord-017897-mbwm0ytg 173 1 Respir Respir NNP cord-017897-mbwm0ytg 173 2 Care Care NNP cord-017897-mbwm0ytg 173 3 Inhaled inhale VBD cord-017897-mbwm0ytg 173 4 nitric nitric JJ cord-017897-mbwm0ytg 173 5 oxide oxide NN cord-017897-mbwm0ytg 173 6 does do VBZ cord-017897-mbwm0ytg 173 7 not not RB cord-017897-mbwm0ytg 173 8 reduce reduce VB cord-017897-mbwm0ytg 173 9 mortality mortality NN cord-017897-mbwm0ytg 173 10 in in IN cord-017897-mbwm0ytg 173 11 patients patient NNS cord-017897-mbwm0ytg 173 12 with with IN cord-017897-mbwm0ytg 173 13 acute acute JJ cord-017897-mbwm0ytg 173 14 respiratory respiratory JJ cord-017897-mbwm0ytg 173 15 distress distress NN cord-017897-mbwm0ytg 173 16 syndrome syndrome NN cord-017897-mbwm0ytg 173 17 regardless regardless RB cord-017897-mbwm0ytg 173 18 of of IN cord-017897-mbwm0ytg 173 19 severity severity NN cord-017897-mbwm0ytg 173 20 : : : cord-017897-mbwm0ytg 173 21 systematic systematic JJ cord-017897-mbwm0ytg 173 22 review review NN cord-017897-mbwm0ytg 173 23 and and CC cord-017897-mbwm0ytg 173 24 meta meta NNP cord-017897-mbwm0ytg 173 25 - - HYPH cord-017897-mbwm0ytg 173 26 analysis analysis NN cord-017897-mbwm0ytg 173 27 Efficacy Efficacy NNP cord-017897-mbwm0ytg 173 28 and and CC cord-017897-mbwm0ytg 173 29 economic economic JJ cord-017897-mbwm0ytg 173 30 assessment assessment NN cord-017897-mbwm0ytg 173 31 of of IN cord-017897-mbwm0ytg 173 32 conventional conventional JJ cord-017897-mbwm0ytg 173 33 ventilatory ventilatory JJ cord-017897-mbwm0ytg 173 34 support support NN cord-017897-mbwm0ytg 173 35 versus versus IN cord-017897-mbwm0ytg 173 36 extracorporeal extracorporeal JJ cord-017897-mbwm0ytg 173 37 membrane membrane NN cord-017897-mbwm0ytg 173 38 oxygenation oxygenation NN cord-017897-mbwm0ytg 173 39 for for IN cord-017897-mbwm0ytg 173 40 severe severe JJ cord-017897-mbwm0ytg 173 41 adult adult NN cord-017897-mbwm0ytg 173 42 respiratory respiratory JJ cord-017897-mbwm0ytg 173 43 failure failure NN cord-017897-mbwm0ytg 173 44 ( ( -LRB- cord-017897-mbwm0ytg 173 45 CESAR CESAR NNP cord-017897-mbwm0ytg 173 46 ) ) -RRB- cord-017897-mbwm0ytg 173 47 : : : cord-017897-mbwm0ytg 173 48 a a DT cord-017897-mbwm0ytg 173 49 multicentre multicentre NNP cord-017897-mbwm0ytg 173 50 randomised randomise VBN cord-017897-mbwm0ytg 173 51 controlled control VBN cord-017897-mbwm0ytg 173 52 trial trial NN cord-017897-mbwm0ytg 173 53 Extracorporeal extracorporeal JJ cord-017897-mbwm0ytg 173 54 life life NN cord-017897-mbwm0ytg 173 55 support support NN cord-017897-mbwm0ytg 173 56 in in IN cord-017897-mbwm0ytg 173 57 critically critically RB cord-017897-mbwm0ytg 173 58 ill ill JJ cord-017897-mbwm0ytg 173 59 adults adult NNS cord-017897-mbwm0ytg 173 60 Respiratory respiratory JJ cord-017897-mbwm0ytg 173 61 failure failure NN cord-017897-mbwm0ytg 173 62 in in IN cord-017897-mbwm0ytg 173 63 the the DT cord-017897-mbwm0ytg 173 64 elderly elderly JJ cord-017897-mbwm0ytg 173 65 Effect effect NN cord-017897-mbwm0ytg 173 66 of of IN cord-017897-mbwm0ytg 173 67 failed fail VBN cord-017897-mbwm0ytg 173 68 extubation extubation NN cord-017897-mbwm0ytg 173 69 on on IN cord-017897-mbwm0ytg 173 70 the the DT cord-017897-mbwm0ytg 173 71 outcome outcome NN cord-017897-mbwm0ytg 173 72 of of IN cord-017897-mbwm0ytg 173 73 mechanical mechanical JJ cord-017897-mbwm0ytg 173 74 ventilation ventilation NN cord-017897-mbwm0ytg 173 75 Weaning wean VBG cord-017897-mbwm0ytg 173 76 from from IN cord-017897-mbwm0ytg 173 77 mechanical mechanical JJ cord-017897-mbwm0ytg 173 78 ventilation ventilation NN cord-017897-mbwm0ytg 174 1 Significant significant JJ cord-017897-mbwm0ytg 174 2 tracheal tracheal JJ cord-017897-mbwm0ytg 174 3 obstruction obstruction NN cord-017897-mbwm0ytg 174 4 causing cause VBG cord-017897-mbwm0ytg 174 5 failure failure NN cord-017897-mbwm0ytg 174 6 to to TO cord-017897-mbwm0ytg 174 7 wean wean VB cord-017897-mbwm0ytg 174 8 in in IN cord-017897-mbwm0ytg 174 9 patients patient NNS cord-017897-mbwm0ytg 174 10 requiring require VBG cord-017897-mbwm0ytg 174 11 prolonged prolong VBN cord-017897-mbwm0ytg 174 12 mechanical mechanical JJ cord-017897-mbwm0ytg 174 13 ventilation ventilation NN cord-017897-mbwm0ytg 174 14 : : : cord-017897-mbwm0ytg 174 15 a a DT cord-017897-mbwm0ytg 174 16 forgotten forget VBN cord-017897-mbwm0ytg 174 17 complication complication NN cord-017897-mbwm0ytg 174 18 of of IN cord-017897-mbwm0ytg 174 19 long long JJ cord-017897-mbwm0ytg 174 20 - - HYPH cord-017897-mbwm0ytg 174 21 term term NN cord-017897-mbwm0ytg 174 22 mechanical mechanical JJ cord-017897-mbwm0ytg 174 23 ventilation ventilation NN cord-017897-mbwm0ytg 174 24 Neurologic neurologic JJ cord-017897-mbwm0ytg 174 25 status status NN cord-017897-mbwm0ytg 174 26 , , , cord-017897-mbwm0ytg 174 27 cough cough NN cord-017897-mbwm0ytg 174 28 , , , cord-017897-mbwm0ytg 174 29 secretions secretion NNS cord-017897-mbwm0ytg 174 30 and and CC cord-017897-mbwm0ytg 174 31 extubation extubation NN cord-017897-mbwm0ytg 174 32 outcomes outcome NNS cord-017897-mbwm0ytg 175 1 A a DT cord-017897-mbwm0ytg 175 2 clinical clinical JJ cord-017897-mbwm0ytg 175 3 prediction prediction NN cord-017897-mbwm0ytg 175 4 rule rule NN cord-017897-mbwm0ytg 175 5 for for IN cord-017897-mbwm0ytg 175 6 delirium delirium NN cord-017897-mbwm0ytg 175 7 after after IN cord-017897-mbwm0ytg 175 8 elective elective JJ cord-017897-mbwm0ytg 175 9 noncardiac noncardiac NNP cord-017897-mbwm0ytg 175 10 surgery surgery NN cord-017897-mbwm0ytg 175 11 Efficacy Efficacy NNP cord-017897-mbwm0ytg 175 12 and and CC cord-017897-mbwm0ytg 175 13 safety safety NN cord-017897-mbwm0ytg 175 14 of of IN cord-017897-mbwm0ytg 175 15 a a DT cord-017897-mbwm0ytg 175 16 paired paired JJ cord-017897-mbwm0ytg 175 17 sedation sedation NN cord-017897-mbwm0ytg 175 18 and and CC cord-017897-mbwm0ytg 175 19 ventilator ventilator NN cord-017897-mbwm0ytg 175 20 weaning wean VBG cord-017897-mbwm0ytg 175 21 protocol protocol NN cord-017897-mbwm0ytg 175 22 for for IN cord-017897-mbwm0ytg 175 23 mechanically mechanically RB cord-017897-mbwm0ytg 175 24 ventilated ventilate VBN cord-017897-mbwm0ytg 175 25 patients patient NNS cord-017897-mbwm0ytg 175 26 in in IN cord-017897-mbwm0ytg 175 27 intensive intensive JJ cord-017897-mbwm0ytg 175 28 care care NN cord-017897-mbwm0ytg 175 29 ( ( -LRB- cord-017897-mbwm0ytg 175 30 A a DT cord-017897-mbwm0ytg 175 31 wakening wakening JJ cord-017897-mbwm0ytg 175 32 and and CC cord-017897-mbwm0ytg 175 33 Breathing Breathing NNP cord-017897-mbwm0ytg 175 34 Controlled Controlled NNP cord-017897-mbwm0ytg 175 35 trial trial NN cord-017897-mbwm0ytg 175 36 ) ) -RRB- cord-017897-mbwm0ytg 176 1 : : : cord-017897-mbwm0ytg 176 2 a a DT cord-017897-mbwm0ytg 176 3 randomised randomised JJ cord-017897-mbwm0ytg 176 4 controlled control VBN cord-017897-mbwm0ytg 176 5 trial trial NN cord-017897-mbwm0ytg 176 6 Depressive depressive JJ cord-017897-mbwm0ytg 176 7 disorders disorder NNS cord-017897-mbwm0ytg 176 8 during during IN cord-017897-mbwm0ytg 176 9 weaning wean VBG cord-017897-mbwm0ytg 176 10 from from IN cord-017897-mbwm0ytg 176 11 prolonged prolong VBN cord-017897-mbwm0ytg 176 12 mechanical mechanical JJ cord-017897-mbwm0ytg 176 13 ventilation ventilation NN cord-017897-mbwm0ytg 176 14 Treatment treatment NN cord-017897-mbwm0ytg 176 15 of of IN cord-017897-mbwm0ytg 176 16 depression depression NN cord-017897-mbwm0ytg 176 17 with with IN cord-017897-mbwm0ytg 176 18 methylphenidate methylphenidate NN cord-017897-mbwm0ytg 176 19 in in IN cord-017897-mbwm0ytg 176 20 patients patient NNS cord-017897-mbwm0ytg 176 21 difficult difficult JJ cord-017897-mbwm0ytg 176 22 to to TO cord-017897-mbwm0ytg 176 23 wean wean VB cord-017897-mbwm0ytg 176 24 from from IN cord-017897-mbwm0ytg 176 25 mechanical mechanical JJ cord-017897-mbwm0ytg 176 26 ventilation ventilation NN cord-017897-mbwm0ytg 176 27 in in IN cord-017897-mbwm0ytg 176 28 the the DT cord-017897-mbwm0ytg 176 29 intensive intensive JJ cord-017897-mbwm0ytg 176 30 care care NN cord-017897-mbwm0ytg 176 31 unit unit NN cord-017897-mbwm0ytg 176 32 Clinical clinical JJ cord-017897-mbwm0ytg 176 33 review review NN cord-017897-mbwm0ytg 177 1 : : : cord-017897-mbwm0ytg 177 2 the the DT cord-017897-mbwm0ytg 177 3 ABC ABC NNP cord-017897-mbwm0ytg 177 4 of of IN cord-017897-mbwm0ytg 177 5 weaning wean VBG cord-017897-mbwm0ytg 177 6 failure failure NN cord-017897-mbwm0ytg 177 7 -- -- : cord-017897-mbwm0ytg 177 8 a a DT cord-017897-mbwm0ytg 177 9 structured structured JJ cord-017897-mbwm0ytg 177 10 approach approach NN cord-017897-mbwm0ytg 177 11 Is be VBZ cord-017897-mbwm0ytg 177 12 weaning wean VBG cord-017897-mbwm0ytg 177 13 failure failure NN cord-017897-mbwm0ytg 177 14 caused cause VBN cord-017897-mbwm0ytg 177 15 by by IN cord-017897-mbwm0ytg 177 16 low low JJ cord-017897-mbwm0ytg 177 17 - - HYPH cord-017897-mbwm0ytg 177 18 frequency frequency NN cord-017897-mbwm0ytg 177 19 fatigue fatigue NN cord-017897-mbwm0ytg 177 20 of of IN cord-017897-mbwm0ytg 177 21 the the DT cord-017897-mbwm0ytg 177 22 diaphragm diaphragm NN cord-017897-mbwm0ytg 177 23 ? ? . cord-017897-mbwm0ytg 178 1 Maximal maximal JJ cord-017897-mbwm0ytg 178 2 respiratory respiratory JJ cord-017897-mbwm0ytg 178 3 pressures pressure NNS cord-017897-mbwm0ytg 178 4 : : : cord-017897-mbwm0ytg 178 5 normal normal JJ cord-017897-mbwm0ytg 178 6 values value NNS cord-017897-mbwm0ytg 178 7 and and CC cord-017897-mbwm0ytg 178 8 relationship relationship NN cord-017897-mbwm0ytg 178 9 to to IN cord-017897-mbwm0ytg 178 10 age age NN cord-017897-mbwm0ytg 178 11 and and CC cord-017897-mbwm0ytg 178 12 sex sex NN cord-017897-mbwm0ytg 179 1 A a DT cord-017897-mbwm0ytg 179 2 prospective prospective JJ cord-017897-mbwm0ytg 179 3 study study NN cord-017897-mbwm0ytg 179 4 of of IN cord-017897-mbwm0ytg 179 5 indexes index NNS cord-017897-mbwm0ytg 179 6 predicting predict VBG cord-017897-mbwm0ytg 179 7 the the DT cord-017897-mbwm0ytg 179 8 outcome outcome NN cord-017897-mbwm0ytg 179 9 of of IN cord-017897-mbwm0ytg 179 10 trials trial NNS cord-017897-mbwm0ytg 179 11 of of IN cord-017897-mbwm0ytg 179 12 weaning wean VBG cord-017897-mbwm0ytg 179 13 from from IN cord-017897-mbwm0ytg 179 14 mechanical mechanical JJ cord-017897-mbwm0ytg 179 15 ventilation ventilation NN cord-017897-mbwm0ytg 179 16 Effect effect NN cord-017897-mbwm0ytg 179 17 on on IN cord-017897-mbwm0ytg 179 18 the the DT cord-017897-mbwm0ytg 179 19 duration duration NN cord-017897-mbwm0ytg 179 20 of of IN cord-017897-mbwm0ytg 179 21 mechanical mechanical JJ cord-017897-mbwm0ytg 179 22 ventilation ventilation NN cord-017897-mbwm0ytg 179 23 of of IN cord-017897-mbwm0ytg 179 24 identifying identify VBG cord-017897-mbwm0ytg 179 25 patients patient NNS cord-017897-mbwm0ytg 179 26 capable capable JJ cord-017897-mbwm0ytg 179 27 of of IN cord-017897-mbwm0ytg 179 28 breathing breathe VBG cord-017897-mbwm0ytg 179 29 spontaneously spontaneously RB cord-017897-mbwm0ytg 179 30 Liberation Liberation NNP cord-017897-mbwm0ytg 179 31 from from IN cord-017897-mbwm0ytg 179 32 mechanical mechanical JJ cord-017897-mbwm0ytg 179 33 ventilation ventilation NN cord-017897-mbwm0ytg 179 34 in in IN cord-017897-mbwm0ytg 179 35 critically critically RB cord-017897-mbwm0ytg 179 36 ill ill JJ cord-017897-mbwm0ytg 179 37 adults adult NNS cord-017897-mbwm0ytg 179 38 : : : cord-017897-mbwm0ytg 180 1 an an DT cord-017897-mbwm0ytg 180 2 official official JJ cord-017897-mbwm0ytg 180 3 American American NNP cord-017897-mbwm0ytg 180 4 College College NNP cord-017897-mbwm0ytg 180 5 of of IN cord-017897-mbwm0ytg 180 6 Chest Chest NNP cord-017897-mbwm0ytg 180 7 Physicians/ physicians/ CD cord-017897-mbwm0ytg 180 8 American American NNP cord-017897-mbwm0ytg 180 9 Thoracic Thoracic NNP cord-017897-mbwm0ytg 180 10 Society Society NNP cord-017897-mbwm0ytg 180 11 clinical clinical JJ cord-017897-mbwm0ytg 180 12 practice practice NN cord-017897-mbwm0ytg 180 13 guideline guideline NN cord-017897-mbwm0ytg 180 14 : : : cord-017897-mbwm0ytg 180 15 inspiratory inspiratory JJ cord-017897-mbwm0ytg 180 16 pressure pressure NN cord-017897-mbwm0ytg 180 17 augmentation augmentation NN cord-017897-mbwm0ytg 180 18 during during IN cord-017897-mbwm0ytg 180 19 spontaneous spontaneous JJ cord-017897-mbwm0ytg 180 20 breathing breathing NN cord-017897-mbwm0ytg 180 21 trials trial NNS cord-017897-mbwm0ytg 180 22 , , , cord-017897-mbwm0ytg 180 23 protocols protocol NNS cord-017897-mbwm0ytg 180 24 minimizing minimize VBG cord-017897-mbwm0ytg 180 25 sedation sedation NN cord-017897-mbwm0ytg 180 26 , , , cord-017897-mbwm0ytg 180 27 and and CC cord-017897-mbwm0ytg 180 28 noninvasive noninvasive JJ cord-017897-mbwm0ytg 180 29 ventilation ventilation NN cord-017897-mbwm0ytg 180 30 immediately immediately RB cord-017897-mbwm0ytg 180 31 after after IN cord-017897-mbwm0ytg 180 32 extubation extubation NN